data_9F8T
# 
_entry.id   9F8T 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9F8T         pdb_00009f8t 10.2210/pdb9f8t/pdb 
WWPDB D_1292138410 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-21 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9F8T 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-07 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              djo30@cam.ac.uk 
_pdbx_contact_author.name_first         David 
_pdbx_contact_author.name_last          Owen 
_pdbx_contact_author.name_mi            J. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8351-6322 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wrobel, A.G.' 1 0000-0002-6680-5587 
'Owen, D.J.'   2 0000-0002-8351-6322 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Clathrin terminal domain complexed with C-terminus of AAK1L' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wrobel, A.G.'  1 0000-0002-6680-5587 
primary 'Owen, D.J.'    2 0000-0002-8351-6322 
primary 'Kadlecova, Z.' 3 0000-0001-6335-1105 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Clathrin heavy chain 1'          40396.340 1   ?        ? ? ? 
2 polymer syn 'AP2-associated protein kinase 1' 715.793   2   2.7.11.1 ? ? 
'Peptide derived from the C-terminus of the long isoform of AAK1 (AAK1L)' 
3 water   nat water                             18.015    384 ?        ? ? ? 
# 
_entity_name_com.entity_id   2 
_entity_name_com.name        'Adaptor-associated kinase 1' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVI
ALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDA
KQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGN
QPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNR
KGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEEL
;
;MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVI
ALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDA
KQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGN
QPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNR
KGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEEL
;
A   ? 
2 'polypeptide(L)' no no DQLIDL DQLIDL D,E ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   GLN n 
1 4   ILE n 
1 5   LEU n 
1 6   PRO n 
1 7   ILE n 
1 8   ARG n 
1 9   PHE n 
1 10  GLN n 
1 11  GLU n 
1 12  HIS n 
1 13  LEU n 
1 14  GLN n 
1 15  LEU n 
1 16  GLN n 
1 17  ASN n 
1 18  LEU n 
1 19  GLY n 
1 20  ILE n 
1 21  ASN n 
1 22  PRO n 
1 23  ALA n 
1 24  ASN n 
1 25  ILE n 
1 26  GLY n 
1 27  PHE n 
1 28  SER n 
1 29  THR n 
1 30  LEU n 
1 31  THR n 
1 32  MET n 
1 33  GLU n 
1 34  SER n 
1 35  ASP n 
1 36  LYS n 
1 37  PHE n 
1 38  ILE n 
1 39  CYS n 
1 40  ILE n 
1 41  ARG n 
1 42  GLU n 
1 43  LYS n 
1 44  VAL n 
1 45  GLY n 
1 46  GLU n 
1 47  GLN n 
1 48  ALA n 
1 49  GLN n 
1 50  VAL n 
1 51  VAL n 
1 52  ILE n 
1 53  ILE n 
1 54  ASP n 
1 55  MET n 
1 56  ASN n 
1 57  ASP n 
1 58  PRO n 
1 59  SER n 
1 60  ASN n 
1 61  PRO n 
1 62  ILE n 
1 63  ARG n 
1 64  ARG n 
1 65  PRO n 
1 66  ILE n 
1 67  SER n 
1 68  ALA n 
1 69  ASP n 
1 70  SER n 
1 71  ALA n 
1 72  ILE n 
1 73  MET n 
1 74  ASN n 
1 75  PRO n 
1 76  ALA n 
1 77  SER n 
1 78  LYS n 
1 79  VAL n 
1 80  ILE n 
1 81  ALA n 
1 82  LEU n 
1 83  LYS n 
1 84  ALA n 
1 85  GLY n 
1 86  LYS n 
1 87  THR n 
1 88  LEU n 
1 89  GLN n 
1 90  ILE n 
1 91  PHE n 
1 92  ASN n 
1 93  ILE n 
1 94  GLU n 
1 95  MET n 
1 96  LYS n 
1 97  SER n 
1 98  LYS n 
1 99  MET n 
1 100 LYS n 
1 101 ALA n 
1 102 HIS n 
1 103 THR n 
1 104 MET n 
1 105 THR n 
1 106 ASP n 
1 107 ASP n 
1 108 VAL n 
1 109 THR n 
1 110 PHE n 
1 111 TRP n 
1 112 LYS n 
1 113 TRP n 
1 114 ILE n 
1 115 SER n 
1 116 LEU n 
1 117 ASN n 
1 118 THR n 
1 119 VAL n 
1 120 ALA n 
1 121 LEU n 
1 122 VAL n 
1 123 THR n 
1 124 ASP n 
1 125 ASN n 
1 126 ALA n 
1 127 VAL n 
1 128 TYR n 
1 129 HIS n 
1 130 TRP n 
1 131 SER n 
1 132 MET n 
1 133 GLU n 
1 134 GLY n 
1 135 GLU n 
1 136 SER n 
1 137 GLN n 
1 138 PRO n 
1 139 VAL n 
1 140 LYS n 
1 141 MET n 
1 142 PHE n 
1 143 ASP n 
1 144 ARG n 
1 145 HIS n 
1 146 SER n 
1 147 SER n 
1 148 LEU n 
1 149 ALA n 
1 150 GLY n 
1 151 CYS n 
1 152 GLN n 
1 153 ILE n 
1 154 ILE n 
1 155 ASN n 
1 156 TYR n 
1 157 ARG n 
1 158 THR n 
1 159 ASP n 
1 160 ALA n 
1 161 LYS n 
1 162 GLN n 
1 163 LYS n 
1 164 TRP n 
1 165 LEU n 
1 166 LEU n 
1 167 LEU n 
1 168 THR n 
1 169 GLY n 
1 170 ILE n 
1 171 SER n 
1 172 ALA n 
1 173 GLN n 
1 174 GLN n 
1 175 ASN n 
1 176 ARG n 
1 177 VAL n 
1 178 VAL n 
1 179 GLY n 
1 180 ALA n 
1 181 MET n 
1 182 GLN n 
1 183 LEU n 
1 184 TYR n 
1 185 SER n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 LYS n 
1 190 VAL n 
1 191 SER n 
1 192 GLN n 
1 193 PRO n 
1 194 ILE n 
1 195 GLU n 
1 196 GLY n 
1 197 HIS n 
1 198 ALA n 
1 199 ALA n 
1 200 SER n 
1 201 PHE n 
1 202 ALA n 
1 203 GLN n 
1 204 PHE n 
1 205 LYS n 
1 206 MET n 
1 207 GLU n 
1 208 GLY n 
1 209 ASN n 
1 210 ALA n 
1 211 GLU n 
1 212 GLU n 
1 213 SER n 
1 214 THR n 
1 215 LEU n 
1 216 PHE n 
1 217 CYS n 
1 218 PHE n 
1 219 ALA n 
1 220 VAL n 
1 221 ARG n 
1 222 GLY n 
1 223 GLN n 
1 224 ALA n 
1 225 GLY n 
1 226 GLY n 
1 227 LYS n 
1 228 LEU n 
1 229 HIS n 
1 230 ILE n 
1 231 ILE n 
1 232 GLU n 
1 233 VAL n 
1 234 GLY n 
1 235 THR n 
1 236 PRO n 
1 237 PRO n 
1 238 THR n 
1 239 GLY n 
1 240 ASN n 
1 241 GLN n 
1 242 PRO n 
1 243 PHE n 
1 244 PRO n 
1 245 LYS n 
1 246 LYS n 
1 247 ALA n 
1 248 VAL n 
1 249 ASP n 
1 250 VAL n 
1 251 PHE n 
1 252 PHE n 
1 253 PRO n 
1 254 PRO n 
1 255 GLU n 
1 256 ALA n 
1 257 GLN n 
1 258 ASN n 
1 259 ASP n 
1 260 PHE n 
1 261 PRO n 
1 262 VAL n 
1 263 ALA n 
1 264 MET n 
1 265 GLN n 
1 266 ILE n 
1 267 SER n 
1 268 GLU n 
1 269 LYS n 
1 270 HIS n 
1 271 ASP n 
1 272 VAL n 
1 273 VAL n 
1 274 PHE n 
1 275 LEU n 
1 276 ILE n 
1 277 THR n 
1 278 LYS n 
1 279 TYR n 
1 280 GLY n 
1 281 TYR n 
1 282 ILE n 
1 283 HIS n 
1 284 LEU n 
1 285 TYR n 
1 286 ASP n 
1 287 LEU n 
1 288 GLU n 
1 289 THR n 
1 290 GLY n 
1 291 THR n 
1 292 CYS n 
1 293 ILE n 
1 294 TYR n 
1 295 MET n 
1 296 ASN n 
1 297 ARG n 
1 298 ILE n 
1 299 SER n 
1 300 GLY n 
1 301 GLU n 
1 302 THR n 
1 303 ILE n 
1 304 PHE n 
1 305 VAL n 
1 306 THR n 
1 307 ALA n 
1 308 PRO n 
1 309 HIS n 
1 310 GLU n 
1 311 ALA n 
1 312 THR n 
1 313 ALA n 
1 314 GLY n 
1 315 ILE n 
1 316 ILE n 
1 317 GLY n 
1 318 VAL n 
1 319 ASN n 
1 320 ARG n 
1 321 LYS n 
1 322 GLY n 
1 323 GLN n 
1 324 VAL n 
1 325 LEU n 
1 326 SER n 
1 327 VAL n 
1 328 CYS n 
1 329 VAL n 
1 330 GLU n 
1 331 GLU n 
1 332 GLU n 
1 333 ASN n 
1 334 ILE n 
1 335 ILE n 
1 336 PRO n 
1 337 TYR n 
1 338 ILE n 
1 339 THR n 
1 340 ASN n 
1 341 VAL n 
1 342 LEU n 
1 343 GLN n 
1 344 ASN n 
1 345 PRO n 
1 346 ASP n 
1 347 LEU n 
1 348 ALA n 
1 349 LEU n 
1 350 ARG n 
1 351 MET n 
1 352 ALA n 
1 353 VAL n 
1 354 ARG n 
1 355 ASN n 
1 356 ASN n 
1 357 LEU n 
1 358 ALA n 
1 359 GLY n 
1 360 ALA n 
1 361 GLU n 
1 362 GLU n 
1 363 LEU n 
2 1   ASP n 
2 2   GLN n 
2 3   LEU n 
2 4   ILE n 
2 5   ASP n 
2 6   LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   363 
_entity_src_gen.gene_src_common_name               'domestic cattle' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 CLTC 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Bos taurus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9913 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli DH5[alpha]' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     668369 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       6 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   ALA 2   2   2   ALA ALA A . n 
A 1 3   GLN 3   3   3   GLN GLN A . n 
A 1 4   ILE 4   4   4   ILE ILE A . n 
A 1 5   LEU 5   5   5   LEU LEU A . n 
A 1 6   PRO 6   6   6   PRO PRO A . n 
A 1 7   ILE 7   7   7   ILE ILE A . n 
A 1 8   ARG 8   8   8   ARG ARG A . n 
A 1 9   PHE 9   9   9   PHE PHE A . n 
A 1 10  GLN 10  10  10  GLN GLN A . n 
A 1 11  GLU 11  11  11  GLU GLU A . n 
A 1 12  HIS 12  12  12  HIS HIS A . n 
A 1 13  LEU 13  13  13  LEU LEU A . n 
A 1 14  GLN 14  14  14  GLN GLN A . n 
A 1 15  LEU 15  15  15  LEU LEU A . n 
A 1 16  GLN 16  16  16  GLN GLN A . n 
A 1 17  ASN 17  17  17  ASN ASN A . n 
A 1 18  LEU 18  18  18  LEU LEU A . n 
A 1 19  GLY 19  19  19  GLY GLY A . n 
A 1 20  ILE 20  20  20  ILE ILE A . n 
A 1 21  ASN 21  21  21  ASN ASN A . n 
A 1 22  PRO 22  22  22  PRO PRO A . n 
A 1 23  ALA 23  23  23  ALA ALA A . n 
A 1 24  ASN 24  24  24  ASN ASN A . n 
A 1 25  ILE 25  25  25  ILE ILE A . n 
A 1 26  GLY 26  26  26  GLY GLY A . n 
A 1 27  PHE 27  27  27  PHE PHE A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  THR 31  31  31  THR THR A . n 
A 1 32  MET 32  32  32  MET MET A . n 
A 1 33  GLU 33  33  33  GLU GLU A . n 
A 1 34  SER 34  34  34  SER SER A . n 
A 1 35  ASP 35  35  35  ASP ASP A . n 
A 1 36  LYS 36  36  36  LYS LYS A . n 
A 1 37  PHE 37  37  37  PHE PHE A . n 
A 1 38  ILE 38  38  38  ILE ILE A . n 
A 1 39  CYS 39  39  39  CYS CYS A . n 
A 1 40  ILE 40  40  40  ILE ILE A . n 
A 1 41  ARG 41  41  41  ARG ARG A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  VAL 44  44  44  VAL VAL A . n 
A 1 45  GLY 45  45  45  GLY GLY A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  GLN 47  47  47  GLN GLN A . n 
A 1 48  ALA 48  48  48  ALA ALA A . n 
A 1 49  GLN 49  49  49  GLN GLN A . n 
A 1 50  VAL 50  50  50  VAL VAL A . n 
A 1 51  VAL 51  51  51  VAL VAL A . n 
A 1 52  ILE 52  52  52  ILE ILE A . n 
A 1 53  ILE 53  53  53  ILE ILE A . n 
A 1 54  ASP 54  54  54  ASP ASP A . n 
A 1 55  MET 55  55  55  MET MET A . n 
A 1 56  ASN 56  56  56  ASN ASN A . n 
A 1 57  ASP 57  57  57  ASP ASP A . n 
A 1 58  PRO 58  58  58  PRO PRO A . n 
A 1 59  SER 59  59  59  SER SER A . n 
A 1 60  ASN 60  60  60  ASN ASN A . n 
A 1 61  PRO 61  61  61  PRO PRO A . n 
A 1 62  ILE 62  62  62  ILE ILE A . n 
A 1 63  ARG 63  63  63  ARG ARG A . n 
A 1 64  ARG 64  64  64  ARG ARG A . n 
A 1 65  PRO 65  65  65  PRO PRO A . n 
A 1 66  ILE 66  66  66  ILE ILE A . n 
A 1 67  SER 67  67  67  SER SER A . n 
A 1 68  ALA 68  68  68  ALA ALA A . n 
A 1 69  ASP 69  69  69  ASP ASP A . n 
A 1 70  SER 70  70  70  SER SER A . n 
A 1 71  ALA 71  71  71  ALA ALA A . n 
A 1 72  ILE 72  72  72  ILE ILE A . n 
A 1 73  MET 73  73  73  MET MET A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  PRO 75  75  75  PRO PRO A . n 
A 1 76  ALA 76  76  76  ALA ALA A . n 
A 1 77  SER 77  77  77  SER SER A . n 
A 1 78  LYS 78  78  78  LYS LYS A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  ALA 81  81  81  ALA ALA A . n 
A 1 82  LEU 82  82  82  LEU LEU A . n 
A 1 83  LYS 83  83  83  LYS LYS A . n 
A 1 84  ALA 84  84  84  ALA ALA A . n 
A 1 85  GLY 85  85  85  GLY GLY A . n 
A 1 86  LYS 86  86  86  LYS LYS A . n 
A 1 87  THR 87  87  87  THR THR A . n 
A 1 88  LEU 88  88  88  LEU LEU A . n 
A 1 89  GLN 89  89  89  GLN GLN A . n 
A 1 90  ILE 90  90  90  ILE ILE A . n 
A 1 91  PHE 91  91  91  PHE PHE A . n 
A 1 92  ASN 92  92  92  ASN ASN A . n 
A 1 93  ILE 93  93  93  ILE ILE A . n 
A 1 94  GLU 94  94  94  GLU GLU A . n 
A 1 95  MET 95  95  95  MET MET A . n 
A 1 96  LYS 96  96  96  LYS LYS A . n 
A 1 97  SER 97  97  97  SER SER A . n 
A 1 98  LYS 98  98  98  LYS LYS A . n 
A 1 99  MET 99  99  99  MET MET A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 ALA 101 101 101 ALA ALA A . n 
A 1 102 HIS 102 102 102 HIS HIS A . n 
A 1 103 THR 103 103 103 THR THR A . n 
A 1 104 MET 104 104 104 MET MET A . n 
A 1 105 THR 105 105 105 THR THR A . n 
A 1 106 ASP 106 106 106 ASP ASP A . n 
A 1 107 ASP 107 107 107 ASP ASP A . n 
A 1 108 VAL 108 108 108 VAL VAL A . n 
A 1 109 THR 109 109 109 THR THR A . n 
A 1 110 PHE 110 110 110 PHE PHE A . n 
A 1 111 TRP 111 111 111 TRP TRP A . n 
A 1 112 LYS 112 112 112 LYS LYS A . n 
A 1 113 TRP 113 113 113 TRP TRP A . n 
A 1 114 ILE 114 114 114 ILE ILE A . n 
A 1 115 SER 115 115 115 SER SER A . n 
A 1 116 LEU 116 116 116 LEU LEU A . n 
A 1 117 ASN 117 117 117 ASN ASN A . n 
A 1 118 THR 118 118 118 THR THR A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 ALA 120 120 120 ALA ALA A . n 
A 1 121 LEU 121 121 121 LEU LEU A . n 
A 1 122 VAL 122 122 122 VAL VAL A . n 
A 1 123 THR 123 123 123 THR THR A . n 
A 1 124 ASP 124 124 124 ASP ASP A . n 
A 1 125 ASN 125 125 125 ASN ASN A . n 
A 1 126 ALA 126 126 126 ALA ALA A . n 
A 1 127 VAL 127 127 127 VAL VAL A . n 
A 1 128 TYR 128 128 128 TYR TYR A . n 
A 1 129 HIS 129 129 129 HIS HIS A . n 
A 1 130 TRP 130 130 130 TRP TRP A . n 
A 1 131 SER 131 131 131 SER SER A . n 
A 1 132 MET 132 132 132 MET MET A . n 
A 1 133 GLU 133 133 133 GLU GLU A . n 
A 1 134 GLY 134 134 134 GLY GLY A . n 
A 1 135 GLU 135 135 135 GLU GLU A . n 
A 1 136 SER 136 136 136 SER SER A . n 
A 1 137 GLN 137 137 137 GLN GLN A . n 
A 1 138 PRO 138 138 138 PRO PRO A . n 
A 1 139 VAL 139 139 139 VAL VAL A . n 
A 1 140 LYS 140 140 140 LYS LYS A . n 
A 1 141 MET 141 141 141 MET MET A . n 
A 1 142 PHE 142 142 142 PHE PHE A . n 
A 1 143 ASP 143 143 143 ASP ASP A . n 
A 1 144 ARG 144 144 144 ARG ARG A . n 
A 1 145 HIS 145 145 145 HIS HIS A . n 
A 1 146 SER 146 146 146 SER SER A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 LEU 148 148 148 LEU LEU A . n 
A 1 149 ALA 149 149 149 ALA ALA A . n 
A 1 150 GLY 150 150 150 GLY GLY A . n 
A 1 151 CYS 151 151 151 CYS CYS A . n 
A 1 152 GLN 152 152 152 GLN GLN A . n 
A 1 153 ILE 153 153 153 ILE ILE A . n 
A 1 154 ILE 154 154 154 ILE ILE A . n 
A 1 155 ASN 155 155 155 ASN ASN A . n 
A 1 156 TYR 156 156 156 TYR TYR A . n 
A 1 157 ARG 157 157 157 ARG ARG A . n 
A 1 158 THR 158 158 158 THR THR A . n 
A 1 159 ASP 159 159 159 ASP ASP A . n 
A 1 160 ALA 160 160 160 ALA ALA A . n 
A 1 161 LYS 161 161 161 LYS LYS A . n 
A 1 162 GLN 162 162 162 GLN GLN A . n 
A 1 163 LYS 163 163 163 LYS LYS A . n 
A 1 164 TRP 164 164 164 TRP TRP A . n 
A 1 165 LEU 165 165 165 LEU LEU A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 THR 168 168 168 THR THR A . n 
A 1 169 GLY 169 169 169 GLY GLY A . n 
A 1 170 ILE 170 170 170 ILE ILE A . n 
A 1 171 SER 171 171 171 SER SER A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 GLN 173 173 173 GLN GLN A . n 
A 1 174 GLN 174 174 174 GLN GLN A . n 
A 1 175 ASN 175 175 175 ASN ASN A . n 
A 1 176 ARG 176 176 176 ARG ARG A . n 
A 1 177 VAL 177 177 177 VAL VAL A . n 
A 1 178 VAL 178 178 178 VAL VAL A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 MET 181 181 181 MET MET A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 LEU 183 183 183 LEU LEU A . n 
A 1 184 TYR 184 184 184 TYR TYR A . n 
A 1 185 SER 185 185 185 SER SER A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 LYS 189 189 189 LYS LYS A . n 
A 1 190 VAL 190 190 190 VAL VAL A . n 
A 1 191 SER 191 191 191 SER SER A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 PRO 193 193 193 PRO PRO A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 GLU 195 195 195 GLU GLU A . n 
A 1 196 GLY 196 196 196 GLY GLY A . n 
A 1 197 HIS 197 197 197 HIS HIS A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 ALA 199 199 199 ALA ALA A . n 
A 1 200 SER 200 200 200 SER SER A . n 
A 1 201 PHE 201 201 201 PHE PHE A . n 
A 1 202 ALA 202 202 202 ALA ALA A . n 
A 1 203 GLN 203 203 203 GLN GLN A . n 
A 1 204 PHE 204 204 204 PHE PHE A . n 
A 1 205 LYS 205 205 205 LYS LYS A . n 
A 1 206 MET 206 206 206 MET MET A . n 
A 1 207 GLU 207 207 207 GLU GLU A . n 
A 1 208 GLY 208 208 208 GLY GLY A . n 
A 1 209 ASN 209 209 209 ASN ASN A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 GLU 211 211 211 GLU GLU A . n 
A 1 212 GLU 212 212 212 GLU GLU A . n 
A 1 213 SER 213 213 213 SER SER A . n 
A 1 214 THR 214 214 214 THR THR A . n 
A 1 215 LEU 215 215 215 LEU LEU A . n 
A 1 216 PHE 216 216 216 PHE PHE A . n 
A 1 217 CYS 217 217 217 CYS CYS A . n 
A 1 218 PHE 218 218 218 PHE PHE A . n 
A 1 219 ALA 219 219 219 ALA ALA A . n 
A 1 220 VAL 220 220 220 VAL VAL A . n 
A 1 221 ARG 221 221 221 ARG ARG A . n 
A 1 222 GLY 222 222 222 GLY GLY A . n 
A 1 223 GLN 223 223 223 GLN GLN A . n 
A 1 224 ALA 224 224 224 ALA ALA A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 GLY 226 226 226 GLY GLY A . n 
A 1 227 LYS 227 227 227 LYS LYS A . n 
A 1 228 LEU 228 228 228 LEU LEU A . n 
A 1 229 HIS 229 229 229 HIS HIS A . n 
A 1 230 ILE 230 230 230 ILE ILE A . n 
A 1 231 ILE 231 231 231 ILE ILE A . n 
A 1 232 GLU 232 232 232 GLU GLU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 GLY 234 234 234 GLY GLY A . n 
A 1 235 THR 235 235 235 THR THR A . n 
A 1 236 PRO 236 236 236 PRO PRO A . n 
A 1 237 PRO 237 237 237 PRO PRO A . n 
A 1 238 THR 238 238 238 THR THR A . n 
A 1 239 GLY 239 239 239 GLY GLY A . n 
A 1 240 ASN 240 240 240 ASN ASN A . n 
A 1 241 GLN 241 241 241 GLN GLN A . n 
A 1 242 PRO 242 242 242 PRO PRO A . n 
A 1 243 PHE 243 243 243 PHE PHE A . n 
A 1 244 PRO 244 244 244 PRO PRO A . n 
A 1 245 LYS 245 245 245 LYS LYS A . n 
A 1 246 LYS 246 246 246 LYS LYS A . n 
A 1 247 ALA 247 247 247 ALA ALA A . n 
A 1 248 VAL 248 248 248 VAL VAL A . n 
A 1 249 ASP 249 249 249 ASP ASP A . n 
A 1 250 VAL 250 250 250 VAL VAL A . n 
A 1 251 PHE 251 251 251 PHE PHE A . n 
A 1 252 PHE 252 252 252 PHE PHE A . n 
A 1 253 PRO 253 253 253 PRO PRO A . n 
A 1 254 PRO 254 254 254 PRO PRO A . n 
A 1 255 GLU 255 255 255 GLU GLU A . n 
A 1 256 ALA 256 256 256 ALA ALA A . n 
A 1 257 GLN 257 257 257 GLN GLN A . n 
A 1 258 ASN 258 258 258 ASN ASN A . n 
A 1 259 ASP 259 259 259 ASP ASP A . n 
A 1 260 PHE 260 260 260 PHE PHE A . n 
A 1 261 PRO 261 261 261 PRO PRO A . n 
A 1 262 VAL 262 262 262 VAL VAL A . n 
A 1 263 ALA 263 263 263 ALA ALA A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 GLN 265 265 265 GLN GLN A . n 
A 1 266 ILE 266 266 266 ILE ILE A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 GLU 268 268 268 GLU GLU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 HIS 270 270 270 HIS HIS A . n 
A 1 271 ASP 271 271 271 ASP ASP A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 VAL 273 273 273 VAL VAL A . n 
A 1 274 PHE 274 274 274 PHE PHE A . n 
A 1 275 LEU 275 275 275 LEU LEU A . n 
A 1 276 ILE 276 276 276 ILE ILE A . n 
A 1 277 THR 277 277 277 THR THR A . n 
A 1 278 LYS 278 278 278 LYS LYS A . n 
A 1 279 TYR 279 279 279 TYR TYR A . n 
A 1 280 GLY 280 280 280 GLY GLY A . n 
A 1 281 TYR 281 281 281 TYR TYR A . n 
A 1 282 ILE 282 282 282 ILE ILE A . n 
A 1 283 HIS 283 283 283 HIS HIS A . n 
A 1 284 LEU 284 284 284 LEU LEU A . n 
A 1 285 TYR 285 285 285 TYR TYR A . n 
A 1 286 ASP 286 286 286 ASP ASP A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 THR 289 289 289 THR THR A . n 
A 1 290 GLY 290 290 290 GLY GLY A . n 
A 1 291 THR 291 291 291 THR THR A . n 
A 1 292 CYS 292 292 292 CYS CYS A . n 
A 1 293 ILE 293 293 293 ILE ILE A . n 
A 1 294 TYR 294 294 294 TYR TYR A . n 
A 1 295 MET 295 295 295 MET MET A . n 
A 1 296 ASN 296 296 296 ASN ASN A . n 
A 1 297 ARG 297 297 297 ARG ARG A . n 
A 1 298 ILE 298 298 298 ILE ILE A . n 
A 1 299 SER 299 299 299 SER SER A . n 
A 1 300 GLY 300 300 300 GLY GLY A . n 
A 1 301 GLU 301 301 301 GLU GLU A . n 
A 1 302 THR 302 302 302 THR THR A . n 
A 1 303 ILE 303 303 303 ILE ILE A . n 
A 1 304 PHE 304 304 304 PHE PHE A . n 
A 1 305 VAL 305 305 305 VAL VAL A . n 
A 1 306 THR 306 306 306 THR THR A . n 
A 1 307 ALA 307 307 307 ALA ALA A . n 
A 1 308 PRO 308 308 308 PRO PRO A . n 
A 1 309 HIS 309 309 309 HIS HIS A . n 
A 1 310 GLU 310 310 310 GLU GLU A . n 
A 1 311 ALA 311 311 311 ALA ALA A . n 
A 1 312 THR 312 312 312 THR THR A . n 
A 1 313 ALA 313 313 313 ALA ALA A . n 
A 1 314 GLY 314 314 314 GLY GLY A . n 
A 1 315 ILE 315 315 315 ILE ILE A . n 
A 1 316 ILE 316 316 316 ILE ILE A . n 
A 1 317 GLY 317 317 317 GLY GLY A . n 
A 1 318 VAL 318 318 318 VAL VAL A . n 
A 1 319 ASN 319 319 319 ASN ASN A . n 
A 1 320 ARG 320 320 320 ARG ARG A . n 
A 1 321 LYS 321 321 321 LYS LYS A . n 
A 1 322 GLY 322 322 322 GLY GLY A . n 
A 1 323 GLN 323 323 323 GLN GLN A . n 
A 1 324 VAL 324 324 324 VAL VAL A . n 
A 1 325 LEU 325 325 325 LEU LEU A . n 
A 1 326 SER 326 326 326 SER SER A . n 
A 1 327 VAL 327 327 327 VAL VAL A . n 
A 1 328 CYS 328 328 328 CYS CYS A . n 
A 1 329 VAL 329 329 329 VAL VAL A . n 
A 1 330 GLU 330 330 330 GLU GLU A . n 
A 1 331 GLU 331 331 331 GLU GLU A . n 
A 1 332 GLU 332 332 332 GLU GLU A . n 
A 1 333 ASN 333 333 333 ASN ASN A . n 
A 1 334 ILE 334 334 334 ILE ILE A . n 
A 1 335 ILE 335 335 335 ILE ILE A . n 
A 1 336 PRO 336 336 336 PRO PRO A . n 
A 1 337 TYR 337 337 337 TYR TYR A . n 
A 1 338 ILE 338 338 338 ILE ILE A . n 
A 1 339 THR 339 339 339 THR THR A . n 
A 1 340 ASN 340 340 340 ASN ASN A . n 
A 1 341 VAL 341 341 341 VAL VAL A . n 
A 1 342 LEU 342 342 342 LEU LEU A . n 
A 1 343 GLN 343 343 343 GLN GLN A . n 
A 1 344 ASN 344 344 344 ASN ASN A . n 
A 1 345 PRO 345 345 345 PRO PRO A . n 
A 1 346 ASP 346 346 346 ASP ASP A . n 
A 1 347 LEU 347 347 347 LEU LEU A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 LEU 349 349 349 LEU LEU A . n 
A 1 350 ARG 350 350 350 ARG ARG A . n 
A 1 351 MET 351 351 351 MET MET A . n 
A 1 352 ALA 352 352 352 ALA ALA A . n 
A 1 353 VAL 353 353 353 VAL VAL A . n 
A 1 354 ARG 354 354 354 ARG ARG A . n 
A 1 355 ASN 355 355 355 ASN ASN A . n 
A 1 356 ASN 356 356 356 ASN ASN A . n 
A 1 357 LEU 357 357 357 LEU LEU A . n 
A 1 358 ALA 358 358 358 ALA ALA A . n 
A 1 359 GLY 359 359 359 GLY GLY A . n 
A 1 360 ALA 360 360 360 ALA ALA A . n 
A 1 361 GLU 361 361 361 GLU GLU A . n 
A 1 362 GLU 362 362 362 GLU GLU A . n 
A 1 363 LEU 363 363 363 LEU LEU A . n 
B 2 1   ASP 1   956 956 ASP ASP D . n 
B 2 2   GLN 2   957 957 GLN GLN D . n 
B 2 3   LEU 3   958 958 LEU LEU D . n 
B 2 4   ILE 4   959 959 ILE ILE D . n 
B 2 5   ASP 5   960 960 ASP ASP D . n 
B 2 6   LEU 6   961 961 LEU LEU D . n 
C 2 1   ASP 1   956 956 ASP ASP E . n 
C 2 2   GLN 2   957 957 GLN GLN E . n 
C 2 3   LEU 3   958 958 LEU LEU E . n 
C 2 4   ILE 4   959 959 ILE ILE E . n 
C 2 5   ASP 5   960 960 ASP ASP E . n 
C 2 6   LEU 6   961 961 LEU LEU E . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 3 HOH 1   401  360 HOH HOH A . 
D 3 HOH 2   402  184 HOH HOH A . 
D 3 HOH 3   403  334 HOH HOH A . 
D 3 HOH 4   404  256 HOH HOH A . 
D 3 HOH 5   405  86  HOH HOH A . 
D 3 HOH 6   406  273 HOH HOH A . 
D 3 HOH 7   407  264 HOH HOH A . 
D 3 HOH 8   408  419 HOH HOH A . 
D 3 HOH 9   409  211 HOH HOH A . 
D 3 HOH 10  410  201 HOH HOH A . 
D 3 HOH 11  411  203 HOH HOH A . 
D 3 HOH 12  412  309 HOH HOH A . 
D 3 HOH 13  413  229 HOH HOH A . 
D 3 HOH 14  414  222 HOH HOH A . 
D 3 HOH 15  415  223 HOH HOH A . 
D 3 HOH 16  416  130 HOH HOH A . 
D 3 HOH 17  417  186 HOH HOH A . 
D 3 HOH 18  418  199 HOH HOH A . 
D 3 HOH 19  419  163 HOH HOH A . 
D 3 HOH 20  420  286 HOH HOH A . 
D 3 HOH 21  421  210 HOH HOH A . 
D 3 HOH 22  422  272 HOH HOH A . 
D 3 HOH 23  423  111 HOH HOH A . 
D 3 HOH 24  424  346 HOH HOH A . 
D 3 HOH 25  425  121 HOH HOH A . 
D 3 HOH 26  426  335 HOH HOH A . 
D 3 HOH 27  427  208 HOH HOH A . 
D 3 HOH 28  428  97  HOH HOH A . 
D 3 HOH 29  429  125 HOH HOH A . 
D 3 HOH 30  430  140 HOH HOH A . 
D 3 HOH 31  431  250 HOH HOH A . 
D 3 HOH 32  432  185 HOH HOH A . 
D 3 HOH 33  433  15  HOH HOH A . 
D 3 HOH 34  434  265 HOH HOH A . 
D 3 HOH 35  435  120 HOH HOH A . 
D 3 HOH 36  436  17  HOH HOH A . 
D 3 HOH 37  437  394 HOH HOH A . 
D 3 HOH 38  438  50  HOH HOH A . 
D 3 HOH 39  439  221 HOH HOH A . 
D 3 HOH 40  440  234 HOH HOH A . 
D 3 HOH 41  441  249 HOH HOH A . 
D 3 HOH 42  442  45  HOH HOH A . 
D 3 HOH 43  443  177 HOH HOH A . 
D 3 HOH 44  444  408 HOH HOH A . 
D 3 HOH 45  445  244 HOH HOH A . 
D 3 HOH 46  446  26  HOH HOH A . 
D 3 HOH 47  447  253 HOH HOH A . 
D 3 HOH 48  448  255 HOH HOH A . 
D 3 HOH 49  449  34  HOH HOH A . 
D 3 HOH 50  450  319 HOH HOH A . 
D 3 HOH 51  451  68  HOH HOH A . 
D 3 HOH 52  452  220 HOH HOH A . 
D 3 HOH 53  453  90  HOH HOH A . 
D 3 HOH 54  454  188 HOH HOH A . 
D 3 HOH 55  455  75  HOH HOH A . 
D 3 HOH 56  456  232 HOH HOH A . 
D 3 HOH 57  457  170 HOH HOH A . 
D 3 HOH 58  458  145 HOH HOH A . 
D 3 HOH 59  459  364 HOH HOH A . 
D 3 HOH 60  460  29  HOH HOH A . 
D 3 HOH 61  461  162 HOH HOH A . 
D 3 HOH 62  462  9   HOH HOH A . 
D 3 HOH 63  463  164 HOH HOH A . 
D 3 HOH 64  464  19  HOH HOH A . 
D 3 HOH 65  465  93  HOH HOH A . 
D 3 HOH 66  466  77  HOH HOH A . 
D 3 HOH 67  467  301 HOH HOH A . 
D 3 HOH 68  468  7   HOH HOH A . 
D 3 HOH 69  469  40  HOH HOH A . 
D 3 HOH 70  470  277 HOH HOH A . 
D 3 HOH 71  471  109 HOH HOH A . 
D 3 HOH 72  472  206 HOH HOH A . 
D 3 HOH 73  473  181 HOH HOH A . 
D 3 HOH 74  474  160 HOH HOH A . 
D 3 HOH 75  475  72  HOH HOH A . 
D 3 HOH 76  476  129 HOH HOH A . 
D 3 HOH 77  477  187 HOH HOH A . 
D 3 HOH 78  478  387 HOH HOH A . 
D 3 HOH 79  479  316 HOH HOH A . 
D 3 HOH 80  480  196 HOH HOH A . 
D 3 HOH 81  481  61  HOH HOH A . 
D 3 HOH 82  482  176 HOH HOH A . 
D 3 HOH 83  483  13  HOH HOH A . 
D 3 HOH 84  484  14  HOH HOH A . 
D 3 HOH 85  485  338 HOH HOH A . 
D 3 HOH 86  486  302 HOH HOH A . 
D 3 HOH 87  487  135 HOH HOH A . 
D 3 HOH 88  488  171 HOH HOH A . 
D 3 HOH 89  489  240 HOH HOH A . 
D 3 HOH 90  490  209 HOH HOH A . 
D 3 HOH 91  491  107 HOH HOH A . 
D 3 HOH 92  492  299 HOH HOH A . 
D 3 HOH 93  493  20  HOH HOH A . 
D 3 HOH 94  494  136 HOH HOH A . 
D 3 HOH 95  495  58  HOH HOH A . 
D 3 HOH 96  496  124 HOH HOH A . 
D 3 HOH 97  497  80  HOH HOH A . 
D 3 HOH 98  498  57  HOH HOH A . 
D 3 HOH 99  499  258 HOH HOH A . 
D 3 HOH 100 500  148 HOH HOH A . 
D 3 HOH 101 501  263 HOH HOH A . 
D 3 HOH 102 502  4   HOH HOH A . 
D 3 HOH 103 503  49  HOH HOH A . 
D 3 HOH 104 504  2   HOH HOH A . 
D 3 HOH 105 505  406 HOH HOH A . 
D 3 HOH 106 506  31  HOH HOH A . 
D 3 HOH 107 507  138 HOH HOH A . 
D 3 HOH 108 508  71  HOH HOH A . 
D 3 HOH 109 509  169 HOH HOH A . 
D 3 HOH 110 510  104 HOH HOH A . 
D 3 HOH 111 511  30  HOH HOH A . 
D 3 HOH 112 512  21  HOH HOH A . 
D 3 HOH 113 513  62  HOH HOH A . 
D 3 HOH 114 514  3   HOH HOH A . 
D 3 HOH 115 515  82  HOH HOH A . 
D 3 HOH 116 516  194 HOH HOH A . 
D 3 HOH 117 517  10  HOH HOH A . 
D 3 HOH 118 518  236 HOH HOH A . 
D 3 HOH 119 519  113 HOH HOH A . 
D 3 HOH 120 520  8   HOH HOH A . 
D 3 HOH 121 521  261 HOH HOH A . 
D 3 HOH 122 522  405 HOH HOH A . 
D 3 HOH 123 523  349 HOH HOH A . 
D 3 HOH 124 524  168 HOH HOH A . 
D 3 HOH 125 525  345 HOH HOH A . 
D 3 HOH 126 526  51  HOH HOH A . 
D 3 HOH 127 527  63  HOH HOH A . 
D 3 HOH 128 528  156 HOH HOH A . 
D 3 HOH 129 529  44  HOH HOH A . 
D 3 HOH 130 530  56  HOH HOH A . 
D 3 HOH 131 531  155 HOH HOH A . 
D 3 HOH 132 532  368 HOH HOH A . 
D 3 HOH 133 533  23  HOH HOH A . 
D 3 HOH 134 534  247 HOH HOH A . 
D 3 HOH 135 535  304 HOH HOH A . 
D 3 HOH 136 536  134 HOH HOH A . 
D 3 HOH 137 537  60  HOH HOH A . 
D 3 HOH 138 538  67  HOH HOH A . 
D 3 HOH 139 539  228 HOH HOH A . 
D 3 HOH 140 540  1   HOH HOH A . 
D 3 HOH 141 541  39  HOH HOH A . 
D 3 HOH 142 542  267 HOH HOH A . 
D 3 HOH 143 543  74  HOH HOH A . 
D 3 HOH 144 544  172 HOH HOH A . 
D 3 HOH 145 545  117 HOH HOH A . 
D 3 HOH 146 546  142 HOH HOH A . 
D 3 HOH 147 547  150 HOH HOH A . 
D 3 HOH 148 548  119 HOH HOH A . 
D 3 HOH 149 549  219 HOH HOH A . 
D 3 HOH 150 550  88  HOH HOH A . 
D 3 HOH 151 551  128 HOH HOH A . 
D 3 HOH 152 552  65  HOH HOH A . 
D 3 HOH 153 553  59  HOH HOH A . 
D 3 HOH 154 554  149 HOH HOH A . 
D 3 HOH 155 555  205 HOH HOH A . 
D 3 HOH 156 556  11  HOH HOH A . 
D 3 HOH 157 557  6   HOH HOH A . 
D 3 HOH 158 558  43  HOH HOH A . 
D 3 HOH 159 559  52  HOH HOH A . 
D 3 HOH 160 560  283 HOH HOH A . 
D 3 HOH 161 561  411 HOH HOH A . 
D 3 HOH 162 562  100 HOH HOH A . 
D 3 HOH 163 563  143 HOH HOH A . 
D 3 HOH 164 564  122 HOH HOH A . 
D 3 HOH 165 565  214 HOH HOH A . 
D 3 HOH 166 566  290 HOH HOH A . 
D 3 HOH 167 567  12  HOH HOH A . 
D 3 HOH 168 568  96  HOH HOH A . 
D 3 HOH 169 569  308 HOH HOH A . 
D 3 HOH 170 570  48  HOH HOH A . 
D 3 HOH 171 571  126 HOH HOH A . 
D 3 HOH 172 572  398 HOH HOH A . 
D 3 HOH 173 573  399 HOH HOH A . 
D 3 HOH 174 574  73  HOH HOH A . 
D 3 HOH 175 575  70  HOH HOH A . 
D 3 HOH 176 576  81  HOH HOH A . 
D 3 HOH 177 577  306 HOH HOH A . 
D 3 HOH 178 578  46  HOH HOH A . 
D 3 HOH 179 579  118 HOH HOH A . 
D 3 HOH 180 580  239 HOH HOH A . 
D 3 HOH 181 581  245 HOH HOH A . 
D 3 HOH 182 582  313 HOH HOH A . 
D 3 HOH 183 583  139 HOH HOH A . 
D 3 HOH 184 584  108 HOH HOH A . 
D 3 HOH 185 585  24  HOH HOH A . 
D 3 HOH 186 586  79  HOH HOH A . 
D 3 HOH 187 587  175 HOH HOH A . 
D 3 HOH 188 588  99  HOH HOH A . 
D 3 HOH 189 589  420 HOH HOH A . 
D 3 HOH 190 590  317 HOH HOH A . 
D 3 HOH 191 591  95  HOH HOH A . 
D 3 HOH 192 592  105 HOH HOH A . 
D 3 HOH 193 593  18  HOH HOH A . 
D 3 HOH 194 594  418 HOH HOH A . 
D 3 HOH 195 595  66  HOH HOH A . 
D 3 HOH 196 596  36  HOH HOH A . 
D 3 HOH 197 597  314 HOH HOH A . 
D 3 HOH 198 598  217 HOH HOH A . 
D 3 HOH 199 599  116 HOH HOH A . 
D 3 HOH 200 600  337 HOH HOH A . 
D 3 HOH 201 601  173 HOH HOH A . 
D 3 HOH 202 602  106 HOH HOH A . 
D 3 HOH 203 603  16  HOH HOH A . 
D 3 HOH 204 604  85  HOH HOH A . 
D 3 HOH 205 605  161 HOH HOH A . 
D 3 HOH 206 606  227 HOH HOH A . 
D 3 HOH 207 607  282 HOH HOH A . 
D 3 HOH 208 608  84  HOH HOH A . 
D 3 HOH 209 609  200 HOH HOH A . 
D 3 HOH 210 610  151 HOH HOH A . 
D 3 HOH 211 611  179 HOH HOH A . 
D 3 HOH 212 612  215 HOH HOH A . 
D 3 HOH 213 613  280 HOH HOH A . 
D 3 HOH 214 614  87  HOH HOH A . 
D 3 HOH 215 615  197 HOH HOH A . 
D 3 HOH 216 616  41  HOH HOH A . 
D 3 HOH 217 617  295 HOH HOH A . 
D 3 HOH 218 618  98  HOH HOH A . 
D 3 HOH 219 619  268 HOH HOH A . 
D 3 HOH 220 620  5   HOH HOH A . 
D 3 HOH 221 621  25  HOH HOH A . 
D 3 HOH 222 622  114 HOH HOH A . 
D 3 HOH 223 623  248 HOH HOH A . 
D 3 HOH 224 624  154 HOH HOH A . 
D 3 HOH 225 625  157 HOH HOH A . 
D 3 HOH 226 626  359 HOH HOH A . 
D 3 HOH 227 627  78  HOH HOH A . 
D 3 HOH 228 628  195 HOH HOH A . 
D 3 HOH 229 629  55  HOH HOH A . 
D 3 HOH 230 630  189 HOH HOH A . 
D 3 HOH 231 631  230 HOH HOH A . 
D 3 HOH 232 632  69  HOH HOH A . 
D 3 HOH 233 633  329 HOH HOH A . 
D 3 HOH 234 634  225 HOH HOH A . 
D 3 HOH 235 635  38  HOH HOH A . 
D 3 HOH 236 636  372 HOH HOH A . 
D 3 HOH 237 637  276 HOH HOH A . 
D 3 HOH 238 638  226 HOH HOH A . 
D 3 HOH 239 639  133 HOH HOH A . 
D 3 HOH 240 640  422 HOH HOH A . 
D 3 HOH 241 641  311 HOH HOH A . 
D 3 HOH 242 642  42  HOH HOH A . 
D 3 HOH 243 643  28  HOH HOH A . 
D 3 HOH 244 644  83  HOH HOH A . 
D 3 HOH 245 645  37  HOH HOH A . 
D 3 HOH 246 646  307 HOH HOH A . 
D 3 HOH 247 647  53  HOH HOH A . 
D 3 HOH 248 648  289 HOH HOH A . 
D 3 HOH 249 649  115 HOH HOH A . 
D 3 HOH 250 650  144 HOH HOH A . 
D 3 HOH 251 651  421 HOH HOH A . 
D 3 HOH 252 652  167 HOH HOH A . 
D 3 HOH 253 653  403 HOH HOH A . 
D 3 HOH 254 654  103 HOH HOH A . 
D 3 HOH 255 655  328 HOH HOH A . 
D 3 HOH 256 656  415 HOH HOH A . 
D 3 HOH 257 657  94  HOH HOH A . 
D 3 HOH 258 658  315 HOH HOH A . 
D 3 HOH 259 659  152 HOH HOH A . 
D 3 HOH 260 660  191 HOH HOH A . 
D 3 HOH 261 661  89  HOH HOH A . 
D 3 HOH 262 662  369 HOH HOH A . 
D 3 HOH 263 663  158 HOH HOH A . 
D 3 HOH 264 664  333 HOH HOH A . 
D 3 HOH 265 665  76  HOH HOH A . 
D 3 HOH 266 666  207 HOH HOH A . 
D 3 HOH 267 667  396 HOH HOH A . 
D 3 HOH 268 668  397 HOH HOH A . 
D 3 HOH 269 669  332 HOH HOH A . 
D 3 HOH 270 670  64  HOH HOH A . 
D 3 HOH 271 671  252 HOH HOH A . 
D 3 HOH 272 672  131 HOH HOH A . 
D 3 HOH 273 673  391 HOH HOH A . 
D 3 HOH 274 674  204 HOH HOH A . 
D 3 HOH 275 675  270 HOH HOH A . 
D 3 HOH 276 676  180 HOH HOH A . 
D 3 HOH 277 677  378 HOH HOH A . 
D 3 HOH 278 678  212 HOH HOH A . 
D 3 HOH 279 679  32  HOH HOH A . 
D 3 HOH 280 680  367 HOH HOH A . 
D 3 HOH 281 681  390 HOH HOH A . 
D 3 HOH 282 682  213 HOH HOH A . 
D 3 HOH 283 683  402 HOH HOH A . 
D 3 HOH 284 684  274 HOH HOH A . 
D 3 HOH 285 685  254 HOH HOH A . 
D 3 HOH 286 686  392 HOH HOH A . 
D 3 HOH 287 687  377 HOH HOH A . 
D 3 HOH 288 688  339 HOH HOH A . 
D 3 HOH 289 689  279 HOH HOH A . 
D 3 HOH 290 690  260 HOH HOH A . 
D 3 HOH 291 691  132 HOH HOH A . 
D 3 HOH 292 692  112 HOH HOH A . 
D 3 HOH 293 693  395 HOH HOH A . 
D 3 HOH 294 694  182 HOH HOH A . 
D 3 HOH 295 695  354 HOH HOH A . 
D 3 HOH 296 696  292 HOH HOH A . 
D 3 HOH 297 697  303 HOH HOH A . 
D 3 HOH 298 698  361 HOH HOH A . 
D 3 HOH 299 699  294 HOH HOH A . 
D 3 HOH 300 700  190 HOH HOH A . 
D 3 HOH 301 701  291 HOH HOH A . 
D 3 HOH 302 702  404 HOH HOH A . 
D 3 HOH 303 703  336 HOH HOH A . 
D 3 HOH 304 704  410 HOH HOH A . 
D 3 HOH 305 705  288 HOH HOH A . 
D 3 HOH 306 706  91  HOH HOH A . 
D 3 HOH 307 707  281 HOH HOH A . 
D 3 HOH 308 708  356 HOH HOH A . 
D 3 HOH 309 709  344 HOH HOH A . 
D 3 HOH 310 710  92  HOH HOH A . 
D 3 HOH 311 711  305 HOH HOH A . 
D 3 HOH 312 712  293 HOH HOH A . 
D 3 HOH 313 713  327 HOH HOH A . 
D 3 HOH 314 714  393 HOH HOH A . 
D 3 HOH 315 715  324 HOH HOH A . 
D 3 HOH 316 716  22  HOH HOH A . 
D 3 HOH 317 717  241 HOH HOH A . 
D 3 HOH 318 718  353 HOH HOH A . 
D 3 HOH 319 719  284 HOH HOH A . 
D 3 HOH 320 720  259 HOH HOH A . 
D 3 HOH 321 721  318 HOH HOH A . 
D 3 HOH 322 722  389 HOH HOH A . 
D 3 HOH 323 723  323 HOH HOH A . 
D 3 HOH 324 724  262 HOH HOH A . 
D 3 HOH 325 725  174 HOH HOH A . 
D 3 HOH 326 726  412 HOH HOH A . 
D 3 HOH 327 727  146 HOH HOH A . 
D 3 HOH 328 728  246 HOH HOH A . 
D 3 HOH 329 729  216 HOH HOH A . 
D 3 HOH 330 730  340 HOH HOH A . 
D 3 HOH 331 731  341 HOH HOH A . 
D 3 HOH 332 732  296 HOH HOH A . 
D 3 HOH 333 733  320 HOH HOH A . 
D 3 HOH 334 734  310 HOH HOH A . 
D 3 HOH 335 735  251 HOH HOH A . 
D 3 HOH 336 736  218 HOH HOH A . 
D 3 HOH 337 737  331 HOH HOH A . 
D 3 HOH 338 738  147 HOH HOH A . 
D 3 HOH 339 739  275 HOH HOH A . 
D 3 HOH 340 740  352 HOH HOH A . 
D 3 HOH 341 741  322 HOH HOH A . 
D 3 HOH 342 742  278 HOH HOH A . 
D 3 HOH 343 743  297 HOH HOH A . 
D 3 HOH 344 744  224 HOH HOH A . 
D 3 HOH 345 745  312 HOH HOH A . 
D 3 HOH 346 746  127 HOH HOH A . 
D 3 HOH 347 747  266 HOH HOH A . 
D 3 HOH 348 748  183 HOH HOH A . 
D 3 HOH 349 749  342 HOH HOH A . 
D 3 HOH 350 750  238 HOH HOH A . 
D 3 HOH 351 751  202 HOH HOH A . 
D 3 HOH 352 752  347 HOH HOH A . 
D 3 HOH 353 753  373 HOH HOH A . 
D 3 HOH 354 754  326 HOH HOH A . 
D 3 HOH 355 755  325 HOH HOH A . 
D 3 HOH 356 756  385 HOH HOH A . 
D 3 HOH 357 757  382 HOH HOH A . 
D 3 HOH 358 758  257 HOH HOH A . 
D 3 HOH 359 759  193 HOH HOH A . 
D 3 HOH 360 760  137 HOH HOH A . 
D 3 HOH 361 761  401 HOH HOH A . 
D 3 HOH 362 762  159 HOH HOH A . 
D 3 HOH 363 763  235 HOH HOH A . 
D 3 HOH 364 764  285 HOH HOH A . 
D 3 HOH 365 765  414 HOH HOH A . 
D 3 HOH 366 766  321 HOH HOH A . 
D 3 HOH 367 767  271 HOH HOH A . 
D 3 HOH 368 768  383 HOH HOH A . 
D 3 HOH 369 769  413 HOH HOH A . 
D 3 HOH 370 770  384 HOH HOH A . 
D 3 HOH 371 771  416 HOH HOH A . 
E 3 HOH 1   1001 166 HOH HOH D . 
E 3 HOH 2   1002 243 HOH HOH D . 
E 3 HOH 3   1003 343 HOH HOH D . 
E 3 HOH 4   1004 237 HOH HOH D . 
E 3 HOH 5   1005 102 HOH HOH D . 
E 3 HOH 6   1006 233 HOH HOH D . 
F 3 HOH 1   1001 198 HOH HOH E . 
F 3 HOH 2   1002 192 HOH HOH E . 
F 3 HOH 3   1003 330 HOH HOH E . 
F 3 HOH 4   1004 141 HOH HOH E . 
F 3 HOH 5   1005 351 HOH HOH E . 
F 3 HOH 6   1006 300 HOH HOH E . 
F 3 HOH 7   1007 242 HOH HOH E . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0425            1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? MOSFLM  ? ? ? 7.2.1               2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? '0.3.11 : 19/08/14' 3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? 2.6.1               4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9F8T 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     107.539 
_cell.length_a_esd                 ? 
_cell.length_b                     130.860 
_cell.length_b_esd                 ? 
_cell.length_c                     77.050 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        16 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9F8T 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9F8T 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.24 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          62.04 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '20% PEG 3,350; 100 mM Bis-Tris propane, pH 6.0; 200 mM sodium citrate; 10 mM DTT' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2016-01-22 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9763 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9763 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9F8T 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.71 
_reflns.d_resolution_low                               28.3 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     56178 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           95.47 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                1.87 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          4.83 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.0970 
_reflns.pdbx_Rpim_I_all                                0.0686 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.987 
_reflns.pdbx_CC_star                                   0.997 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.0686 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.71 
_reflns_shell.d_res_low                                     1.77 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.15 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5147 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               1.83 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.640 
_reflns_shell.pdbx_Rpim_I_all                               0.452 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.603 
_reflns_shell.pdbx_CC_star                                  0.867 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          88.8 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.452 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.466 
_refine.aniso_B[1][2]                            0.000 
_refine.aniso_B[1][3]                            -0.000 
_refine.aniso_B[2][2]                            0.588 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            -1.054 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.229 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.966 
_refine.correlation_coeff_Fo_to_Fc_free          0.950 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9F8T 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.711 
_refine.ls_d_res_low                             28.264 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     56177 
_refine.ls_number_reflns_R_free                  2770 
_refine.ls_number_reflns_R_work                  53407 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    95.473 
_refine.ls_percent_reflns_R_free                 4.931 
_refine.ls_R_factor_all                          0.174 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2092 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1723 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.088 
_refine.pdbx_overall_ESU_R_Free                  0.093 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.711 
_refine_hist.d_res_low                        28.264 
_refine_hist.number_atoms_solvent             384 
_refine_hist.number_atoms_total               3317 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2933 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.009  0.012  3046 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.016  2937 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.677  1.805  4137 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 0.906  1.758  6768 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 7.238  5.000  384  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 12.123 5.000  13   ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 12.247 10.000 540  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 14.734 10.000 138  ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.087  0.200  470  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.009  0.020  3599 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.011  0.020  677  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.199  0.200  492  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.213  0.200  2767 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.174  0.200  1491 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.093  0.200  1691 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.174  0.200  302  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.169  0.200  19   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.179  0.200  88   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.254  0.200  29   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 2.538  2.355  1527 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.529  2.354  1527 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 3.837  4.208  1914 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 3.843  4.211  1915 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 3.805  2.800  1519 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.804  2.802  1520 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.962  4.933  2223 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.961  4.934  2224 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 8.051  27.348 3415 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 7.840  25.487 3299 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.711 1.755  4282 . 191 3534 86.9921 . 0.295 . . 0.294 . . . . . 0.294 . 20 . 0.941 0.937 0.313 
'X-RAY DIFFRACTION' 1.755 1.803  4166 . 183 3746 94.3111 . 0.264 . . 0.262 . . . . . 0.262 . 20 . 0.955 0.945 0.298 
'X-RAY DIFFRACTION' 1.803 1.855  4080 . 172 3731 95.6618 . 0.234 . . 0.233 . . . . . 0.233 . 20 . 0.965 0.957 0.258 
'X-RAY DIFFRACTION' 1.855 1.912  3948 . 181 3594 95.6180 . 0.224 . . 0.223 . . . . . 0.223 . 20 . 0.968 0.963 0.234 
'X-RAY DIFFRACTION' 1.912 1.975  3871 . 166 3546 95.8925 . 0.196 . . 0.194 . . . . . 0.194 . 20 . 0.975 0.961 0.249 
'X-RAY DIFFRACTION' 1.975 2.043  3697 . 179 3381 96.2943 . 0.187 . . 0.185 . . . . . 0.185 . 20 . 0.977 0.968 0.226 
'X-RAY DIFFRACTION' 2.043 2.120  3607 . 179 3246 94.9543 . 0.186 . . 0.184 . . . . . 0.184 . 20 . 0.979 0.974 0.219 
'X-RAY DIFFRACTION' 2.120 2.206  3440 . 171 3139 96.2209 . 0.181 . . 0.179 . . . . . 0.179 . 20 . 0.981 0.970 0.220 
'X-RAY DIFFRACTION' 2.206 2.304  3313 . 150 3032 96.0459 . 0.169 . . 0.168 . . . . . 0.168 . 20 . 0.982 0.977 0.186 
'X-RAY DIFFRACTION' 2.304 2.415  3205 . 163 2956 97.3167 . 0.170 . . 0.167 . . . . . 0.167 . 20 . 0.982 0.972 0.219 
'X-RAY DIFFRACTION' 2.415 2.545  3028 . 163 2720 95.2114 . 0.166 . . 0.162 . . . . . 0.162 . 20 . 0.983 0.969 0.226 
'X-RAY DIFFRACTION' 2.545 2.698  2856 . 134 2573 94.7829 . 0.157 . . 0.156 . . . . . 0.156 . 20 . 0.984 0.977 0.188 
'X-RAY DIFFRACTION' 2.698 2.882  2718 . 148 2495 97.2406 . 0.159 . . 0.156 . . . . . 0.156 . 20 . 0.984 0.977 0.196 
'X-RAY DIFFRACTION' 2.882 3.111  2537 . 112 2390 98.6204 . 0.167 . . 0.165 . . . . . 0.165 . 20 . 0.982 0.968 0.220 
'X-RAY DIFFRACTION' 3.111 3.403  2339 . 118 2161 97.4348 . 0.160 . . 0.158 . . . . . 0.158 . 20 . 0.985 0.976 0.196 
'X-RAY DIFFRACTION' 3.403 3.798  2132 . 106 1982 97.9362 . 0.164 . . 0.161 . . . . . 0.161 . 20 . 0.985 0.975 0.214 
'X-RAY DIFFRACTION' 3.798 4.373  1885 . 87  1766 98.3024 . 0.144 . . 0.143 . . . . . 0.143 . 20 . 0.987 0.981 0.172 
'X-RAY DIFFRACTION' 4.373 5.324  1633 . 72  1506 96.6320 . 0.144 . . 0.143 . . . . . 0.143 . 20 . 0.988 0.986 0.167 
'X-RAY DIFFRACTION' 5.324 7.399  1281 . 61  1183 97.1116 . 0.191 . . 0.191 . . . . . 0.191 . 20 . 0.983 0.982 0.191 
'X-RAY DIFFRACTION' 7.399 28.264 805  . 34  726  94.4099 . 0.177 . . 0.175 . . . . . 0.175 . 20 . 0.978 0.972 0.220 
# 
_struct.entry_id                     9F8T 
_struct.title                        'Clathrin terminal domain complexed with C-terminus of AAK1L' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9F8T 
_struct_keywords.text            'membrane traffic, kinase, ENDOCYTOSIS' 
_struct_keywords.pdbx_keywords   ENDOCYTOSIS 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
F N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP CLH1_BOVIN P49951 ? 1 
;MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVI
ALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDA
KQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGN
QPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNR
KGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEEL
;
1   
2 UNP AAK1_HUMAN Q2M2I8 ? 2 DQLIDL 956 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9F8T A 1 ? 363 ? P49951 1   ? 363 ? 1   363 
2 2 9F8T D 1 ? 6   ? Q2M2I8 956 ? 961 ? 956 961 
3 2 9F8T E 1 ? 6   ? Q2M2I8 956 ? 961 ? 956 961 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1840  ? 
1 MORE         -12   ? 
1 'SSA (A^2)'  16920 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                
;Unstructured C-terminus of AAK1L can likely bind either of the two sites on the clathrin terminal domain: the clathrin box or the arrestin box
;
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 GLN A 16  ? GLY A 19  ? GLN A 16  GLY A 19  5 ? 4  
HELX_P HELX_P2 AA2 ASN A 21  ? ILE A 25  ? ASN A 21  ILE A 25  5 ? 5  
HELX_P HELX_P3 AA3 HIS A 145 ? ALA A 149 ? HIS A 145 ALA A 149 5 ? 5  
HELX_P HELX_P4 AA4 PRO A 253 ? GLN A 257 ? PRO A 253 GLN A 257 5 ? 5  
HELX_P HELX_P5 AA5 ASN A 333 ? VAL A 341 ? ASN A 333 VAL A 341 1 ? 9  
HELX_P HELX_P6 AA6 ASN A 344 ? ASN A 356 ? ASN A 344 ASN A 356 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 7   ? GLN A 14  ? ILE A 7   GLN A 14  
AA1 2 GLN A 323 ? VAL A 329 ? GLN A 323 VAL A 329 
AA1 3 GLY A 314 ? ASN A 319 ? GLY A 314 ASN A 319 
AA1 4 ILE A 303 ? HIS A 309 ? ILE A 303 HIS A 309 
AA2 1 LEU A 30  ? SER A 34  ? LEU A 30  SER A 34  
AA2 2 PHE A 37  ? VAL A 44  ? PHE A 37  VAL A 44  
AA2 3 GLN A 47  ? ASP A 54  ? GLN A 47  ASP A 54  
AA2 4 ILE A 62  ? PRO A 65  ? ILE A 62  PRO A 65  
AA3 1 SER A 70  ? MET A 73  ? SER A 70  MET A 73  
AA3 2 VAL A 79  ? ALA A 84  ? VAL A 79  ALA A 84  
AA3 3 THR A 87  ? ASN A 92  ? THR A 87  ASN A 92  
AA3 4 SER A 97  ? THR A 103 ? SER A 97  THR A 103 
AA4 1 VAL A 108 ? TRP A 113 ? VAL A 108 TRP A 113 
AA4 2 THR A 118 ? THR A 123 ? THR A 118 THR A 123 
AA4 3 ALA A 126 ? SER A 131 ? ALA A 126 SER A 131 
AA4 4 VAL A 139 ? ASP A 143 ? VAL A 139 ASP A 143 
AA5 1 GLN A 152 ? THR A 158 ? GLN A 152 THR A 158 
AA5 2 TRP A 164 ? GLN A 173 ? TRP A 164 GLN A 173 
AA5 3 ARG A 176 ? SER A 185 ? ARG A 176 SER A 185 
AA5 4 VAL A 190 ? GLU A 195 ? VAL A 190 GLU A 195 
AA6 1 ALA A 198 ? PHE A 204 ? ALA A 198 PHE A 204 
AA6 2 SER A 213 ? GLY A 222 ? SER A 213 GLY A 222 
AA6 3 GLY A 225 ? GLU A 232 ? GLY A 225 GLU A 232 
AA6 4 LYS A 246 ? VAL A 250 ? LYS A 246 VAL A 250 
AA7 1 PRO A 261 ? SER A 267 ? PRO A 261 SER A 267 
AA7 2 VAL A 272 ? THR A 277 ? VAL A 272 THR A 277 
AA7 3 TYR A 281 ? ASP A 286 ? TYR A 281 ASP A 286 
AA7 4 CYS A 292 ? ARG A 297 ? CYS A 292 ARG A 297 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N HIS A 12  ? N HIS A 12  O VAL A 324 ? O VAL A 324 
AA1 2 3 O LEU A 325 ? O LEU A 325 N GLY A 317 ? N GLY A 317 
AA1 3 4 O ILE A 316 ? O ILE A 316 N ALA A 307 ? N ALA A 307 
AA2 1 2 N THR A 31  ? N THR A 31  O CYS A 39  ? O CYS A 39  
AA2 2 3 N GLU A 42  ? N GLU A 42  O GLN A 49  ? O GLN A 49  
AA2 3 4 N ILE A 52  ? N ILE A 52  O ILE A 62  ? O ILE A 62  
AA3 1 2 N ILE A 72  ? N ILE A 72  O ALA A 81  ? O ALA A 81  
AA3 2 3 N LEU A 82  ? N LEU A 82  O GLN A 89  ? O GLN A 89  
AA3 3 4 N LEU A 88  ? N LEU A 88  O HIS A 102 ? O HIS A 102 
AA4 1 2 N LYS A 112 ? N LYS A 112 O ALA A 120 ? O ALA A 120 
AA4 2 3 N THR A 123 ? N THR A 123 O ALA A 126 ? O ALA A 126 
AA4 3 4 N VAL A 127 ? N VAL A 127 O MET A 141 ? O MET A 141 
AA5 1 2 N GLN A 152 ? N GLN A 152 O ILE A 170 ? O ILE A 170 
AA5 2 3 N GLY A 169 ? N GLY A 169 O ALA A 180 ? O ALA A 180 
AA5 3 4 N MET A 181 ? N MET A 181 O ILE A 194 ? O ILE A 194 
AA6 1 2 N ALA A 202 ? N ALA A 202 O LEU A 215 ? O LEU A 215 
AA6 2 3 N PHE A 216 ? N PHE A 216 O ILE A 231 ? O ILE A 231 
AA6 3 4 N LEU A 228 ? N LEU A 228 O VAL A 248 ? O VAL A 248 
AA7 1 2 N GLN A 265 ? N GLN A 265 O PHE A 274 ? O PHE A 274 
AA7 2 3 N VAL A 273 ? N VAL A 273 O TYR A 285 ? O TYR A 285 
AA7 3 4 N ILE A 282 ? N ILE A 282 O ASN A 296 ? O ASN A 296 
# 
_pdbx_entry_details.entry_id                   9F8T 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 57  ? ? -150.57 57.37   
2 1 ASN A 60  ? ? -119.63 64.07   
3 1 ALA A 256 ? ? -112.28 52.00   
4 1 SER A 299 ? ? -165.47 -166.93 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     320 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.184 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 505 ? D HOH . 
2 1 A HOH 645 ? D HOH . 
3 1 A HOH 724 ? D HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 768 ? 6.46  . 
2 1 O ? A HOH 769 ? 7.08  . 
3 1 O ? A HOH 770 ? 7.25  . 
4 1 O ? A HOH 771 ? 10.83 . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Wellcome Trust' 'United Kingdom' 097040/Z/11/Z 1 
'Wellcome Trust' 'United Kingdom' 090909/Z/09/Z 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1utc 
_pdbx_initial_refinement_model.details          '1UTC_1 (chain A/B)' 
# 
_atom_sites.entry_id                    9F8T 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009299 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007642 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.012979 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C   6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651   51.6512 0.2156   
H   1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408   57.7997 0.0030   
N   7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672   0.5826  -11.5379 
O   8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671   32.9089 0.2508   
O-1 8  9  4.1952  12.8573 1.6411 4.1724  1.5281 47.0179 -20.3246 -0.0140 21.9602  
S   16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863   56.1720 1.0487   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . MET A 1 1   ? 54.651 33.029 8.877   1.000 34.720 0  1    MET A N   1 ? 
ATOM   2    C CA  . MET A 1 1   ? 53.923 31.743 8.697   1.000 36.140 0  1    MET A CA  1 ? 
ATOM   3    C C   . MET A 1 1   ? 52.449 32.028 8.411   1.000 41.060 0  1    MET A C   1 ? 
ATOM   4    O O   . MET A 1 1   ? 51.904 33.031 8.862   1.000 40.680 0  1    MET A O   1 ? 
ATOM   5    C CB  . MET A 1 1   ? 54.055 30.853 9.940   1.000 39.520 0  1    MET A CB  1 ? 
ATOM   6    C CG  . MET A 1 1   ? 55.495 30.413 10.222  1.000 46.060 0  1    MET A CG  1 ? 
ATOM   7    S SD  . MET A 1 1   ? 56.326 29.532 8.875   1.000 46.780 0  1    MET A SD  1 ? 
ATOM   8    C CE  . MET A 1 1   ? 55.317 28.076 8.547   1.000 54.080 0  1    MET A CE  1 ? 
ATOM   9    N N   . ALA A 1 2   ? 51.814 31.130 7.652   1.000 41.320 0  2    ALA A N   1 ? 
ATOM   10   C CA  . ALA A 1 2   ? 50.417 31.297 7.283   1.000 44.640 0  2    ALA A CA  1 ? 
ATOM   11   C C   . ALA A 1 2   ? 49.567 31.273 8.551   1.000 42.480 0  2    ALA A C   1 ? 
ATOM   12   O O   . ALA A 1 2   ? 49.789 30.457 9.448   1.000 35.400 0  2    ALA A O   1 ? 
ATOM   13   C CB  . ALA A 1 2   ? 49.985 30.215 6.316   1.000 43.270 0  2    ALA A CB  1 ? 
ATOM   14   N N   A GLN A 1 3   ? 48.611 32.201 8.619   0.700 46.480 0  3    GLN A N   1 ? 
ATOM   15   N N   B GLN A 1 3   ? 48.594 32.185 8.610   0.300 40.560 0  3    GLN A N   1 ? 
ATOM   16   C CA  A GLN A 1 3   ? 47.664 32.241 9.722   0.700 50.950 0  3    GLN A CA  1 ? 
ATOM   17   C CA  B GLN A 1 3   ? 47.673 32.260 9.730   0.300 40.420 0  3    GLN A CA  1 ? 
ATOM   18   C C   A GLN A 1 3   ? 46.945 30.894 9.813   0.700 42.490 0  3    GLN A C   1 ? 
ATOM   19   C C   B GLN A 1 3   ? 46.891 30.949 9.822   0.300 37.940 0  3    GLN A C   1 ? 
ATOM   20   O O   A GLN A 1 3   ? 46.587 30.311 8.798   0.700 41.440 0  3    GLN A O   1 ? 
ATOM   21   O O   B GLN A 1 3   ? 46.424 30.450 8.804   0.300 36.420 0  3    GLN A O   1 ? 
ATOM   22   C CB  A GLN A 1 3   ? 46.690 33.399 9.495   0.700 56.710 0  3    GLN A CB  1 ? 
ATOM   23   C CB  B GLN A 1 3   ? 46.761 33.462 9.481   0.300 39.850 0  3    GLN A CB  1 ? 
ATOM   24   C CG  A GLN A 1 3   ? 47.135 34.716 10.122  0.700 60.470 0  3    GLN A CG  1 ? 
ATOM   25   C CG  B GLN A 1 3   ? 46.043 33.427 8.133   0.300 38.400 0  3    GLN A CG  1 ? 
ATOM   26   C CD  A GLN A 1 3   ? 46.786 34.790 11.589  0.700 63.340 0  3    GLN A CD  1 ? 
ATOM   27   C CD  B GLN A 1 3   ? 46.902 33.813 6.949   0.300 38.380 0  3    GLN A CD  1 ? 
ATOM   28   O OE1 A GLN A 1 3   ? 46.395 33.788 12.201  0.700 64.580 0  3    GLN A OE1 1 ? 
ATOM   29   O OE1 B GLN A 1 3   ? 47.911 34.518 7.068   0.300 36.840 0  3    GLN A OE1 1 ? 
ATOM   30   N NE2 A GLN A 1 3   ? 46.919 35.979 12.162  0.700 61.370 0  3    GLN A NE2 1 ? 
ATOM   31   N NE2 B GLN A 1 3   ? 46.472 33.383 5.774   0.300 37.900 0  3    GLN A NE2 1 ? 
ATOM   32   N N   . ILE A 1 4   ? 46.759 30.395 11.037  1.000 36.580 0  4    ILE A N   1 ? 
ATOM   33   C CA  . ILE A 1 4   ? 45.876 29.256 11.273  1.000 37.290 0  4    ILE A CA  1 ? 
ATOM   34   C C   . ILE A 1 4   ? 44.463 29.675 10.889  1.000 29.350 0  4    ILE A C   1 ? 
ATOM   35   O O   . ILE A 1 4   ? 44.120 30.848 11.023  1.000 27.200 0  4    ILE A O   1 ? 
ATOM   36   C CB  . ILE A 1 4   ? 45.905 28.785 12.734  1.000 38.040 0  4    ILE A CB  1 ? 
ATOM   37   C CG1 . ILE A 1 4   ? 45.422 29.893 13.695  1.000 39.350 0  4    ILE A CG1 1 ? 
ATOM   38   C CG2 . ILE A 1 4   ? 47.296 28.260 13.089  1.000 40.400 0  4    ILE A CG2 1 ? 
ATOM   39   C CD1 . ILE A 1 4   ? 45.136 29.391 15.099  1.000 43.530 0  4    ILE A CD1 1 ? 
ATOM   40   N N   . LEU A 1 5   ? 43.704 28.729 10.345  1.000 27.850 0  5    LEU A N   1 ? 
ATOM   41   C CA  . LEU A 1 5   ? 42.326 28.981 9.958   1.000 30.120 0  5    LEU A CA  1 ? 
ATOM   42   C C   . LEU A 1 5   ? 41.429 28.168 10.883  1.000 23.050 0  5    LEU A C   1 ? 
ATOM   43   O O   . LEU A 1 5   ? 41.829 27.088 11.294  1.000 23.720 0  5    LEU A O   1 ? 
ATOM   44   C CB  . LEU A 1 5   ? 42.124 28.594 8.496   1.000 33.840 0  5    LEU A CB  1 ? 
ATOM   45   C CG  . LEU A 1 5   ? 42.804 29.498 7.465   1.000 39.880 0  5    LEU A CG  1 ? 
ATOM   46   C CD1 . LEU A 1 5   ? 42.396 29.087 6.066   1.000 43.920 0  5    LEU A CD1 1 ? 
ATOM   47   C CD2 . LEU A 1 5   ? 42.460 30.965 7.698   1.000 41.770 0  5    LEU A CD2 1 ? 
ATOM   48   N N   . PRO A 1 6   ? 40.235 28.684 11.264  1.000 22.410 0  6    PRO A N   1 ? 
ATOM   49   C CA  . PRO A 1 6   ? 39.322 27.935 12.129  1.000 21.290 0  6    PRO A CA  1 ? 
ATOM   50   C C   . PRO A 1 6   ? 38.515 26.871 11.377  1.000 22.640 0  6    PRO A C   1 ? 
ATOM   51   O O   . PRO A 1 6   ? 37.801 26.084 11.997  1.000 21.170 0  6    PRO A O   1 ? 
ATOM   52   C CB  . PRO A 1 6   ? 38.459 29.070 12.671  1.000 21.680 0  6    PRO A CB  1 ? 
ATOM   53   C CG  . PRO A 1 6   ? 38.329 30.025 11.506  1.000 21.590 0  6    PRO A CG  1 ? 
ATOM   54   C CD  . PRO A 1 6   ? 39.716 30.009 10.907  1.000 20.850 0  6    PRO A CD  1 ? 
ATOM   55   N N   . ILE A 1 7   ? 38.633 26.870 10.038  1.000 22.660 0  7    ILE A N   1 ? 
ATOM   56   C CA  . ILE A 1 7   ? 37.924 25.915 9.186   1.000 24.980 0  7    ILE A CA  1 ? 
ATOM   57   C C   . ILE A 1 7   ? 38.932 25.204 8.292   1.000 28.280 0  7    ILE A C   1 ? 
ATOM   58   O O   . ILE A 1 7   ? 40.015 25.755 8.052   1.000 26.790 0  7    ILE A O   1 ? 
ATOM   59   C CB  . ILE A 1 7   ? 36.870 26.634 8.321   1.000 24.780 0  7    ILE A CB  1 ? 
ATOM   60   C CG1 . ILE A 1 7   ? 37.424 27.771 7.511   1.000 31.380 0  7    ILE A CG1 1 ? 
ATOM   61   C CG2 . ILE A 1 7   ? 35.702 27.109 9.170   1.000 23.930 0  7    ILE A CG2 1 ? 
ATOM   62   C CD1 . ILE A 1 7   ? 37.418 27.519 6.021   1.000 39.690 0  7    ILE A CD1 1 ? 
ATOM   63   N N   . ARG A 1 8   ? 38.515 24.040 7.783   1.000 26.380 0  8    ARG A N   1 ? 
ATOM   64   C CA  . ARG A 1 8   ? 39.266 23.253 6.813   1.000 24.670 0  8    ARG A CA  1 ? 
ATOM   65   C C   . ARG A 1 8   ? 38.418 23.061 5.557   1.000 27.900 0  8    ARG A C   1 ? 
ATOM   66   O O   . ARG A 1 8   ? 37.256 22.650 5.654   1.000 24.910 0  8    ARG A O   1 ? 
ATOM   67   C CB  . ARG A 1 8   ? 39.622 21.894 7.414   1.000 30.090 0  8    ARG A CB  1 ? 
ATOM   68   C CG  . ARG A 1 8   ? 40.507 21.054 6.500   1.000 36.900 0  8    ARG A CG  1 ? 
ATOM   69   C CD  . ARG A 1 8   ? 41.084 19.827 7.189   1.000 41.280 0  8    ARG A CD  1 ? 
ATOM   70   N NE  . ARG A 1 8   ? 40.044 18.844 7.510   1.000 46.140 0  8    ARG A NE  1 ? 
ATOM   71   C CZ  . ARG A 1 8   ? 39.548 18.539 8.720   1.000 52.780 0  8    ARG A CZ  1 ? 
ATOM   72   N NH1 . ARG A 1 8   ? 39.972 19.134 9.828   1.000 49.390 0  8    ARG A NH1 1 ? 
ATOM   73   N NH2 . ARG A 1 8   ? 38.578 17.642 8.813   1.000 50.500 0  8    ARG A NH2 1 ? 
ATOM   74   N N   . PHE A 1 9   ? 39.045 23.348 4.417   1.000 24.390 0  9    PHE A N   1 ? 
ATOM   75   C CA  . PHE A 1 9   ? 38.470 23.023 3.130   1.000 25.090 0  9    PHE A CA  1 ? 
ATOM   76   C C   . PHE A 1 9   ? 38.908 21.634 2.703   1.000 26.710 0  9    PHE A C   1 ? 
ATOM   77   O O   . PHE A 1 9   ? 39.967 21.109 3.080   1.000 24.540 0  9    PHE A O   1 ? 
ATOM   78   C CB  . PHE A 1 9   ? 38.917 24.052 2.100   1.000 25.480 0  9    PHE A CB  1 ? 
ATOM   79   C CG  . PHE A 1 9   ? 38.304 25.409 2.367   1.000 25.230 0  9    PHE A CG  1 ? 
ATOM   80   C CD1 . PHE A 1 9   ? 36.994 25.676 1.999   1.000 25.080 0  9    PHE A CD1 1 ? 
ATOM   81   C CD2 . PHE A 1 9   ? 39.028 26.395 3.022   1.000 26.990 0  9    PHE A CD2 1 ? 
ATOM   82   C CE1 . PHE A 1 9   ? 36.429 26.903 2.272   1.000 26.350 0  9    PHE A CE1 1 ? 
ATOM   83   C CE2 . PHE A 1 9   ? 38.461 27.629 3.273   1.000 26.480 0  9    PHE A CE2 1 ? 
ATOM   84   C CZ  . PHE A 1 9   ? 37.164 27.881 2.904   1.000 26.900 0  9    PHE A CZ  1 ? 
ATOM   85   N N   . GLN A 1 10  ? 38.075 21.045 1.861   1.000 25.760 0  10   GLN A N   1 ? 
ATOM   86   C CA  . GLN A 1 10  ? 38.480 19.803 1.224   1.000 29.510 0  10   GLN A CA  1 ? 
ATOM   87   C C   . GLN A 1 10  ? 37.715 19.644 -0.085  1.000 32.420 0  10   GLN A C   1 ? 
ATOM   88   O O   . GLN A 1 10  ? 36.496 19.730 -0.098  1.000 26.940 0  10   GLN A O   1 ? 
ATOM   89   C CB  . GLN A 1 10  ? 38.256 18.593 2.123   1.000 30.910 0  10   GLN A CB  1 ? 
ATOM   90   C CG  . GLN A 1 10  ? 38.675 17.266 1.501   1.000 39.300 0  10   GLN A CG  1 ? 
ATOM   91   C CD  . GLN A 1 10  ? 38.399 16.080 2.403   1.000 48.900 0  10   GLN A CD  1 ? 
ATOM   92   O OE1 . GLN A 1 10  ? 37.936 16.225 3.546   1.000 54.940 0  10   GLN A OE1 1 ? 
ATOM   93   N NE2 . GLN A 1 10  ? 38.664 14.883 1.894   1.000 50.120 0  10   GLN A NE2 1 ? 
ATOM   94   N N   . GLU A 1 11  ? 38.448 19.433 -1.189  1.000 29.810 0  11   GLU A N   1 ? 
ATOM   95   C CA  . GLU A 1 11  ? 37.822 19.100 -2.463  1.000 29.430 0  11   GLU A CA  1 ? 
ATOM   96   C C   . GLU A 1 11  ? 37.644 17.591 -2.540  1.000 29.520 0  11   GLU A C   1 ? 
ATOM   97   O O   . GLU A 1 11  ? 38.592 16.839 -2.360  1.000 34.010 0  11   GLU A O   1 ? 
ATOM   98   C CB  . GLU A 1 11  ? 38.679 19.613 -3.617  1.000 31.760 0  11   GLU A CB  1 ? 
ATOM   99   C CG  . GLU A 1 11  ? 38.092 19.262 -4.977  1.000 34.420 0  11   GLU A CG  1 ? 
ATOM   100  C CD  . GLU A 1 11  ? 38.905 19.734 -6.168  1.000 37.060 0  11   GLU A CD  1 ? 
ATOM   101  O OE1 . GLU A 1 11  ? 39.104 20.937 -6.333  1.000 38.140 0  11   GLU A OE1 1 ? 
ATOM   102  O OE2 . GLU A 1 11  ? 39.301 18.862 -6.955  1.000 46.000 0  11   GLU A OE2 1 ? 
ATOM   103  N N   . HIS A 1 12  ? 36.417 17.126 -2.754  1.000 26.700 0  12   HIS A N   1 ? 
ATOM   104  C CA  . HIS A 1 12  ? 36.157 15.704 -2.773  1.000 27.970 0  12   HIS A CA  1 ? 
ATOM   105  C C   . HIS A 1 12  ? 36.281 15.167 -4.199  1.000 33.610 0  12   HIS A C   1 ? 
ATOM   106  O O   . HIS A 1 12  ? 36.788 14.070 -4.397  1.000 37.450 0  12   HIS A O   1 ? 
ATOM   107  C CB  . HIS A 1 12  ? 34.789 15.402 -2.159  1.000 28.800 0  12   HIS A CB  1 ? 
ATOM   108  C CG  . HIS A 1 12  ? 34.807 15.759 -0.709  1.000 31.270 0  12   HIS A CG  1 ? 
ATOM   109  N ND1 . HIS A 1 12  ? 35.260 14.864 0.236   1.000 34.410 0  12   HIS A ND1 1 ? 
ATOM   110  C CD2 . HIS A 1 12  ? 34.487 16.884 -0.040  1.000 31.940 0  12   HIS A CD2 1 ? 
ATOM   111  C CE1 . HIS A 1 12  ? 35.203 15.440 1.442   1.000 35.220 0  12   HIS A CE1 1 ? 
ATOM   112  N NE2 . HIS A 1 12  ? 34.738 16.660 1.298   1.000 30.500 0  12   HIS A NE2 1 ? 
ATOM   113  N N   . LEU A 1 13  ? 35.798 15.933 -5.172  1.000 30.410 0  13   LEU A N   1 ? 
ATOM   114  C CA  . LEU A 1 13  ? 35.566 15.406 -6.502  1.000 31.030 0  13   LEU A CA  1 ? 
ATOM   115  C C   . LEU A 1 13  ? 35.458 16.578 -7.454  1.000 31.310 0  13   LEU A C   1 ? 
ATOM   116  O O   . LEU A 1 13  ? 35.040 17.663 -7.044  1.000 26.040 0  13   LEU A O   1 ? 
ATOM   117  C CB  . LEU A 1 13  ? 34.276 14.586 -6.378  1.000 34.480 0  13   LEU A CB  1 ? 
ATOM   118  C CG  . LEU A 1 13  ? 33.714 13.907 -7.621  1.000 42.490 0  13   LEU A CG  1 ? 
ATOM   119  C CD1 . LEU A 1 13  ? 34.724 12.965 -8.281  1.000 45.810 0  13   LEU A CD1 1 ? 
ATOM   120  C CD2 . LEU A 1 13  ? 32.437 13.165 -7.198  1.000 40.830 0  13   LEU A CD2 1 ? 
ATOM   121  N N   . GLN A 1 14  ? 35.835 16.339 -8.727  1.000 28.810 0  14   GLN A N   1 ? 
ATOM   122  C CA  . GLN A 1 14  ? 35.504 17.227 -9.820  1.000 26.450 0  14   GLN A CA  1 ? 
ATOM   123  C C   . GLN A 1 14  ? 34.616 16.454 -10.791 1.000 29.020 0  14   GLN A C   1 ? 
ATOM   124  O O   . GLN A 1 14  ? 35.093 15.521 -11.455 1.000 28.690 0  14   GLN A O   1 ? 
ATOM   125  C CB  . GLN A 1 14  ? 36.737 17.726 -10.583 1.000 31.020 0  14   GLN A CB  1 ? 
ATOM   126  C CG  . GLN A 1 14  ? 37.568 18.760 -9.825  1.000 35.630 0  14   GLN A CG  1 ? 
ATOM   127  C CD  . GLN A 1 14  ? 37.069 20.194 -9.906  1.000 38.000 0  14   GLN A CD  1 ? 
ATOM   128  O OE1 . GLN A 1 14  ? 36.155 20.560 -10.658 1.000 38.320 0  14   GLN A OE1 1 ? 
ATOM   129  N NE2 . GLN A 1 14  ? 37.709 21.060 -9.124  1.000 39.900 0  14   GLN A NE2 1 ? 
ATOM   130  N N   . LEU A 1 15  ? 33.355 16.890 -10.933 1.000 24.600 0  15   LEU A N   1 ? 
ATOM   131  C CA  . LEU A 1 15  ? 32.374 16.121 -11.686 1.000 24.050 0  15   LEU A CA  1 ? 
ATOM   132  C C   . LEU A 1 15  ? 32.796 16.051 -13.155 1.000 26.950 0  15   LEU A C   1 ? 
ATOM   133  O O   . LEU A 1 15  ? 32.498 15.078 -13.833 1.000 28.010 0  15   LEU A O   1 ? 
ATOM   134  C CB  . LEU A 1 15  ? 30.958 16.665 -11.545 1.000 25.490 0  15   LEU A CB  1 ? 
ATOM   135  C CG  . LEU A 1 15  ? 30.378 16.577 -10.129 1.000 28.160 0  15   LEU A CG  1 ? 
ATOM   136  C CD1 . LEU A 1 15  ? 29.093 17.356 -10.013 1.000 28.000 0  15   LEU A CD1 1 ? 
ATOM   137  C CD2 . LEU A 1 15  ? 30.134 15.156 -9.760  1.000 30.200 0  15   LEU A CD2 1 ? 
ATOM   138  N N   . GLN A 1 16  ? 33.447 17.093 -13.663 1.000 28.450 0  16   GLN A N   1 ? 
ATOM   139  C CA  . GLN A 1 16  ? 33.907 17.050 -15.044 1.000 31.870 0  16   GLN A CA  1 ? 
ATOM   140  C C   . GLN A 1 16  ? 34.878 15.890 -15.270 1.000 31.970 0  16   GLN A C   1 ? 
ATOM   141  O O   . GLN A 1 16  ? 34.984 15.394 -16.381 1.000 39.970 0  16   GLN A O   1 ? 
ATOM   142  C CB  . GLN A 1 16  ? 34.434 18.412 -15.462 1.000 33.530 0  16   GLN A CB  1 ? 
ATOM   143  C CG  . GLN A 1 16  ? 33.307 19.420 -15.626 1.000 31.820 0  16   GLN A CG  1 ? 
ATOM   144  C CD  . GLN A 1 16  ? 33.781 20.745 -16.165 1.000 42.470 0  16   GLN A CD  1 ? 
ATOM   145  O OE1 . GLN A 1 16  ? 34.259 20.837 -17.295 1.000 45.200 0  16   GLN A OE1 1 ? 
ATOM   146  N NE2 . GLN A 1 16  ? 33.610 21.798 -15.389 1.000 39.200 0  16   GLN A NE2 1 ? 
ATOM   147  N N   . ASN A 1 17  ? 35.534 15.384 -14.238 1.000 31.800 0  17   ASN A N   1 ? 
ATOM   148  C CA  . ASN A 1 17  ? 36.435 14.258 -14.429 1.000 37.510 0  17   ASN A CA  1 ? 
ATOM   149  C C   . ASN A 1 17  ? 35.679 12.944 -14.572 1.000 39.220 0  17   ASN A C   1 ? 
ATOM   150  O O   . ASN A 1 17  ? 36.299 11.922 -14.817 1.000 46.010 0  17   ASN A O   1 ? 
ATOM   151  C CB  . ASN A 1 17  ? 37.428 14.105 -13.287 1.000 39.440 0  17   ASN A CB  1 ? 
ATOM   152  C CG  . ASN A 1 17  ? 38.376 15.274 -13.202 1.000 42.260 0  17   ASN A CG  1 ? 
ATOM   153  O OD1 . ASN A 1 17  ? 38.421 16.123 -14.104 1.000 53.140 0  17   ASN A OD1 1 ? 
ATOM   154  N ND2 . ASN A 1 17  ? 39.122 15.337 -12.113 1.000 44.930 0  17   ASN A ND2 1 ? 
ATOM   155  N N   . LEU A 1 18  ? 34.365 12.941 -14.345 1.000 35.530 0  18   LEU A N   1 ? 
ATOM   156  C CA  . LEU A 1 18  ? 33.581 11.741 -14.513 1.000 37.090 0  18   LEU A CA  1 ? 
ATOM   157  C C   . LEU A 1 18  ? 32.782 11.893 -15.791 1.000 36.900 0  18   LEU A C   1 ? 
ATOM   158  O O   . LEU A 1 18  ? 31.854 11.140 -16.030 1.000 44.980 0  18   LEU A O   1 ? 
ATOM   159  C CB  . LEU A 1 18  ? 32.660 11.498 -13.322 1.000 38.190 0  18   LEU A CB  1 ? 
ATOM   160  C CG  . LEU A 1 18  ? 33.289 11.507 -11.930 1.000 43.640 0  18   LEU A CG  1 ? 
ATOM   161  C CD1 . LEU A 1 18  ? 32.172 11.211 -10.944 1.000 49.080 0  18   LEU A CD1 1 ? 
ATOM   162  C CD2 . LEU A 1 18  ? 34.433 10.535 -11.715 1.000 49.270 0  18   LEU A CD2 1 ? 
ATOM   163  N N   . GLY A 1 19  ? 33.122 12.901 -16.590 1.000 43.800 0  19   GLY A N   1 ? 
ATOM   164  C CA  . GLY A 1 19  ? 32.456 13.128 -17.859 1.000 48.110 0  19   GLY A CA  1 ? 
ATOM   165  C C   . GLY A 1 19  ? 31.029 13.631 -17.671 1.000 51.110 0  19   GLY A C   1 ? 
ATOM   166  O O   . GLY A 1 19  ? 30.143 13.280 -18.445 1.000 55.460 0  19   GLY A O   1 ? 
ATOM   167  N N   . ILE A 1 20  ? 30.802 14.441 -16.629 1.000 46.130 0  20   ILE A N   1 ? 
ATOM   168  C CA  . ILE A 1 20  ? 29.545 15.163 -16.525 1.000 40.210 0  20   ILE A CA  1 ? 
ATOM   169  C C   . ILE A 1 20  ? 29.697 16.442 -17.334 1.000 33.360 0  20   ILE A C   1 ? 
ATOM   170  O O   . ILE A 1 20  ? 30.692 17.147 -17.226 1.000 36.230 0  20   ILE A O   1 ? 
ATOM   171  C CB  . ILE A 1 20  ? 29.125 15.411 -15.056 1.000 36.090 0  20   ILE A CB  1 ? 
ATOM   172  C CG1 . ILE A 1 20  ? 28.725 14.093 -14.384 1.000 42.900 0  20   ILE A CG1 1 ? 
ATOM   173  C CG2 . ILE A 1 20  ? 27.976 16.412 -14.949 1.000 37.050 0  20   ILE A CG2 1 ? 
ATOM   174  C CD1 . ILE A 1 20  ? 29.877 13.387 -13.707 1.000 49.070 0  20   ILE A CD1 1 ? 
ATOM   175  N N   . ASN A 1 21  ? 28.690 16.726 -18.147 1.000 31.200 0  21   ASN A N   1 ? 
ATOM   176  C CA  . ASN A 1 21  ? 28.667 17.935 -18.949 1.000 34.340 0  21   ASN A CA  1 ? 
ATOM   177  C C   . ASN A 1 21  ? 28.293 19.124 -18.070 1.000 38.150 0  21   ASN A C   1 ? 
ATOM   178  O O   . ASN A 1 21  ? 27.250 19.096 -17.410 1.000 31.190 0  21   ASN A O   1 ? 
ATOM   179  C CB  . ASN A 1 21  ? 27.696 17.742 -20.110 1.000 42.970 0  21   ASN A CB  1 ? 
ATOM   180  C CG  . ASN A 1 21  ? 27.666 18.912 -21.063 1.000 43.490 0  21   ASN A CG  1 ? 
ATOM   181  O OD1 . ASN A 1 21  ? 28.051 20.028 -20.709 1.000 49.990 0  21   ASN A OD1 1 ? 
ATOM   182  N ND2 . ASN A 1 21  ? 27.207 18.672 -22.284 1.000 50.330 0  21   ASN A ND2 1 ? 
ATOM   183  N N   . PRO A 1 22  ? 29.127 20.199 -18.049 1.000 40.660 0  22   PRO A N   1 ? 
ATOM   184  C CA  . PRO A 1 22  ? 28.846 21.411 -17.272 1.000 38.060 0  22   PRO A CA  1 ? 
ATOM   185  C C   . PRO A 1 22  ? 27.464 22.015 -17.473 1.000 31.880 0  22   PRO A C   1 ? 
ATOM   186  O O   . PRO A 1 22  ? 26.910 22.637 -16.574 1.000 32.570 0  22   PRO A O   1 ? 
ATOM   187  C CB  . PRO A 1 22  ? 29.935 22.426 -17.685 1.000 42.170 0  22   PRO A CB  1 ? 
ATOM   188  C CG  . PRO A 1 22  ? 30.987 21.619 -18.434 1.000 42.780 0  22   PRO A CG  1 ? 
ATOM   189  C CD  . PRO A 1 22  ? 30.433 20.244 -18.736 1.000 43.880 0  22   PRO A CD  1 ? 
ATOM   190  N N   . ALA A 1 23  ? 26.881 21.810 -18.658 1.000 29.070 0  23   ALA A N   1 ? 
ATOM   191  C CA  . ALA A 1 23  ? 25.546 22.296 -18.922 1.000 29.110 0  23   ALA A CA  1 ? 
ATOM   192  C C   . ALA A 1 23  ? 24.565 21.679 -17.933 1.000 25.910 0  23   ALA A C   1 ? 
ATOM   193  O O   . ALA A 1 23  ? 23.510 22.241 -17.686 1.000 26.140 0  23   ALA A O   1 ? 
ATOM   194  C CB  . ALA A 1 23  ? 25.135 21.987 -20.356 1.000 36.450 0  23   ALA A CB  1 ? 
ATOM   195  N N   . ASN A 1 24  ? 24.913 20.533 -17.353 1.000 25.300 0  24   ASN A N   1 ? 
ATOM   196  C CA  . ASN A 1 24  ? 23.959 19.884 -16.465 1.000 23.420 0  24   ASN A CA  1 ? 
ATOM   197  C C   . ASN A 1 24  ? 24.345 20.068 -15.007 1.000 22.840 0  24   ASN A C   1 ? 
ATOM   198  O O   . ASN A 1 24  ? 23.719 19.467 -14.127 1.000 22.410 0  24   ASN A O   1 ? 
ATOM   199  C CB  . ASN A 1 24  ? 23.870 18.398 -16.745 1.000 24.920 0  24   ASN A CB  1 ? 
ATOM   200  C CG  . ASN A 1 24  ? 23.392 18.152 -18.142 1.000 25.040 0  24   ASN A CG  1 ? 
ATOM   201  O OD1 . ASN A 1 24  ? 22.446 18.791 -18.587 1.000 28.620 0  24   ASN A OD1 1 ? 
ATOM   202  N ND2 . ASN A 1 24  ? 24.074 17.266 -18.838 1.000 26.620 0  24   ASN A ND2 1 ? 
ATOM   203  N N   . ILE A 1 25  ? 25.398 20.857 -14.734 1.000 19.000 0  25   ILE A N   1 ? 
ATOM   204  C CA  . ILE A 1 25  ? 25.736 21.113 -13.353 1.000 19.670 0  25   ILE A CA  1 ? 
ATOM   205  C C   . ILE A 1 25  ? 25.041 22.402 -12.892 1.000 22.250 0  25   ILE A C   1 ? 
ATOM   206  O O   . ILE A 1 25  ? 25.577 23.517 -13.000 1.000 24.900 0  25   ILE A O   1 ? 
ATOM   207  C CB  . ILE A 1 25  ? 27.257 21.146 -13.196 1.000 22.100 0  25   ILE A CB  1 ? 
ATOM   208  C CG1 . ILE A 1 25  ? 27.861 19.858 -13.717 1.000 21.850 0  25   ILE A CG1 1 ? 
ATOM   209  C CG2 . ILE A 1 25  ? 27.648 21.466 -11.751 1.000 22.300 0  25   ILE A CG2 1 ? 
ATOM   210  C CD1 . ILE A 1 25  ? 29.365 19.836 -13.715 1.000 24.620 0  25   ILE A CD1 1 ? 
ATOM   211  N N   . GLY A 1 26  ? 23.844 22.263 -12.328 1.000 20.310 0  26   GLY A N   1 ? 
ATOM   212  C CA  . GLY A 1 26  ? 23.061 23.423 -11.947 1.000 21.960 0  26   GLY A CA  1 ? 
ATOM   213  C C   . GLY A 1 26  ? 21.873 22.984 -11.105 1.000 21.020 0  26   GLY A C   1 ? 
ATOM   214  O O   . GLY A 1 26  ? 21.615 21.798 -11.017 1.000 18.040 0  26   GLY A O   1 ? 
ATOM   215  N N   . PHE A 1 27  ? 21.127 23.951 -10.583 1.000 21.470 0  27   PHE A N   1 ? 
ATOM   216  C CA  . PHE A 1 27  ? 20.142 23.686 -9.545  1.000 21.200 0  27   PHE A CA  1 ? 
ATOM   217  C C   . PHE A 1 27  ? 19.025 22.780 -10.067 1.000 20.630 0  27   PHE A C   1 ? 
ATOM   218  O O   . PHE A 1 27  ? 18.546 21.943 -9.331  1.000 21.680 0  27   PHE A O   1 ? 
ATOM   219  C CB  . PHE A 1 27  ? 19.670 25.055 -9.046  1.000 23.080 0  27   PHE A CB  1 ? 
ATOM   220  C CG  . PHE A 1 27  ? 18.447 24.976 -8.150  1.000 24.980 0  27   PHE A CG  1 ? 
ATOM   221  C CD1 . PHE A 1 27  ? 18.581 24.617 -6.819  1.000 25.820 0  27   PHE A CD1 1 ? 
ATOM   222  C CD2 . PHE A 1 27  ? 17.191 25.288 -8.644  1.000 26.130 0  27   PHE A CD2 1 ? 
ATOM   223  C CE1 . PHE A 1 27  ? 17.460 24.544 -6.003  1.000 27.570 0  27   PHE A CE1 1 ? 
ATOM   224  C CE2 . PHE A 1 27  ? 16.083 25.211 -7.832  1.000 28.360 0  27   PHE A CE2 1 ? 
ATOM   225  C CZ  . PHE A 1 27  ? 16.221 24.869 -6.505  1.000 25.750 0  27   PHE A CZ  1 ? 
ATOM   226  N N   . SER A 1 28  ? 18.647 22.899 -11.342 1.000 21.980 0  28   SER A N   1 ? 
ATOM   227  C CA  . SER A 1 28  ? 17.506 22.138 -11.861 1.000 25.590 0  28   SER A CA  1 ? 
ATOM   228  C C   . SER A 1 28  ? 17.872 20.694 -12.225 1.000 21.740 0  28   SER A C   1 ? 
ATOM   229  O O   . SER A 1 28  ? 16.997 19.859 -12.311 1.000 24.050 0  28   SER A O   1 ? 
ATOM   230  C CB  . SER A 1 28  ? 16.862 22.840 -13.021 1.000 30.120 0  28   SER A CB  1 ? 
ATOM   231  O OG  . SER A 1 28  ? 17.724 22.816 -14.144 1.000 28.460 0  28   SER A OG  1 ? 
ATOM   232  N N   . THR A 1 29  ? 19.146 20.377 -12.441 1.000 20.420 0  29   THR A N   1 ? 
ATOM   233  C CA  . THR A 1 29  ? 19.512 19.076 -12.986 1.000 19.440 0  29   THR A CA  1 ? 
ATOM   234  C C   . THR A 1 29  ? 20.397 18.266 -12.054 1.000 19.580 0  29   THR A C   1 ? 
ATOM   235  O O   . THR A 1 29  ? 20.544 17.077 -12.281 1.000 19.550 0  29   THR A O   1 ? 
ATOM   236  C CB  . THR A 1 29  ? 20.205 19.249 -14.336 1.000 21.300 0  29   THR A CB  1 ? 
ATOM   237  O OG1 . THR A 1 29  ? 21.233 20.201 -14.108 1.000 23.330 0  29   THR A OG1 1 ? 
ATOM   238  C CG2 . THR A 1 29  ? 19.263 19.767 -15.403 1.000 25.970 0  29   THR A CG2 1 ? 
ATOM   239  N N   . LEU A 1 30  ? 21.002 18.872 -11.023 1.000 17.460 0  30   LEU A N   1 ? 
ATOM   240  C CA  . LEU A 1 30  ? 21.916 18.163 -10.144 1.000 17.170 0  30   LEU A CA  1 ? 
ATOM   241  C C   . LEU A 1 30  ? 21.406 18.304 -8.715  1.000 18.790 0  30   LEU A C   1 ? 
ATOM   242  O O   . LEU A 1 30  ? 21.210 19.423 -8.250  1.000 19.520 0  30   LEU A O   1 ? 
ATOM   243  C CB  . LEU A 1 30  ? 23.322 18.739 -10.293 1.000 16.450 0  30   LEU A CB  1 ? 
ATOM   244  C CG  . LEU A 1 30  ? 24.415 18.062 -9.459  1.000 17.290 0  30   LEU A CG  1 ? 
ATOM   245  C CD1 . LEU A 1 30  ? 25.739 18.262 -10.105 1.000 18.400 0  30   LEU A CD1 1 ? 
ATOM   246  C CD2 . LEU A 1 30  ? 24.460 18.551 -8.035  1.000 18.930 0  30   LEU A CD2 1 ? 
ATOM   247  N N   . THR A 1 31  ? 21.175 17.172 -8.040  1.000 18.870 0  31   THR A N   1 ? 
ATOM   248  C CA  . THR A 1 31  ? 20.636 17.167 -6.685  1.000 17.660 0  31   THR A CA  1 ? 
ATOM   249  C C   . THR A 1 31  ? 21.628 16.448 -5.781  1.000 17.930 0  31   THR A C   1 ? 
ATOM   250  O O   . THR A 1 31  ? 22.351 15.533 -6.186  1.000 17.040 0  31   THR A O   1 ? 
ATOM   251  C CB  . THR A 1 31  ? 19.247 16.526 -6.669  1.000 20.180 0  31   THR A CB  1 ? 
ATOM   252  O OG1 . THR A 1 31  ? 19.378 15.235 -7.260  1.000 18.190 0  31   THR A OG1 1 ? 
ATOM   253  C CG2 . THR A 1 31  ? 18.247 17.385 -7.410  1.000 20.800 0  31   THR A CG2 1 ? 
ATOM   254  N N   . MET A 1 32  ? 21.696 16.928 -4.549  1.000 16.070 0  32   MET A N   1 ? 
ATOM   255  C CA  . MET A 1 32  ? 22.548 16.348 -3.544  1.000 16.260 0  32   MET A CA  1 ? 
ATOM   256  C C   . MET A 1 32  ? 21.784 16.477 -2.245  1.000 19.110 0  32   MET A C   1 ? 
ATOM   257  O O   . MET A 1 32  ? 21.842 17.507 -1.579  1.000 19.820 0  32   MET A O   1 ? 
ATOM   258  C CB  . MET A 1 32  ? 23.919 17.030 -3.477  1.000 16.900 0  32   MET A CB  1 ? 
ATOM   259  C CG  . MET A 1 32  ? 24.868 16.378 -2.495  1.000 18.610 0  32   MET A CG  1 ? 
ATOM   260  S SD  . MET A 1 32  ? 26.516 17.128 -2.499  1.000 22.110 0  32   MET A SD  1 ? 
ATOM   261  C CE  . MET A 1 32  ? 26.066 18.721 -1.803  1.000 23.820 0  32   MET A CE  1 ? 
ATOM   262  N N   . GLU A 1 33  ? 21.017 15.424 -1.940  1.000 17.850 0  33   GLU A N   1 ? 
ATOM   263  C CA  . GLU A 1 33  ? 20.105 15.456 -0.821  1.000 18.220 0  33   GLU A CA  1 ? 
ATOM   264  C C   . GLU A 1 33  ? 20.865 15.182 0.468   1.000 19.310 0  33   GLU A C   1 ? 
ATOM   265  O O   . GLU A 1 33  ? 20.356 15.452 1.551   1.000 22.670 0  33   GLU A O   1 ? 
ATOM   266  C CB  . GLU A 1 33  ? 19.012 14.432 -1.152  1.000 19.220 0  33   GLU A CB  1 ? 
ATOM   267  C CG  . GLU A 1 33  ? 18.208 14.811 -2.393  1.000 19.240 0  33   GLU A CG  1 ? 
ATOM   268  C CD  . GLU A 1 33  ? 17.250 15.967 -2.161  1.000 24.350 0  33   GLU A CD  1 ? 
ATOM   269  O OE1 . GLU A 1 33  ? 17.465 17.097 -2.660  1.000 24.980 0  33   GLU A OE1 1 ? 
ATOM   270  O OE2 . GLU A 1 33  ? 16.309 15.771 -1.392  1.000 21.660 0  33   GLU A OE2 1 ? 
ATOM   271  N N   . SER A 1 34  ? 22.024 14.529 0.365   1.000 17.470 0  34   SER A N   1 ? 
ATOM   272  C CA  . SER A 1 34  ? 22.868 14.170 1.483   1.000 18.900 0  34   SER A CA  1 ? 
ATOM   273  C C   . SER A 1 34  ? 24.278 14.047 0.916   1.000 20.300 0  34   SER A C   1 ? 
ATOM   274  O O   . SER A 1 34  ? 24.455 14.090 -0.309  1.000 21.040 0  34   SER A O   1 ? 
ATOM   275  C CB  . SER A 1 34  ? 22.444 12.885 2.155   1.000 19.920 0  34   SER A CB  1 ? 
ATOM   276  O OG  . SER A 1 34  ? 22.853 11.771 1.364   1.000 20.160 0  34   SER A OG  1 ? 
ATOM   277  N N   . ASP A 1 35  ? 25.249 13.772 1.768   1.000 19.280 0  35   ASP A N   1 ? 
ATOM   278  C CA  . ASP A 1 35  ? 26.606 13.640 1.280   1.000 21.980 0  35   ASP A CA  1 ? 
ATOM   279  C C   . ASP A 1 35  ? 26.873 12.253 0.687   1.000 21.670 0  35   ASP A C   1 ? 
ATOM   280  O O   . ASP A 1 35  ? 28.002 11.967 0.334   1.000 22.890 0  35   ASP A O   1 ? 
ATOM   281  C CB  . ASP A 1 35  ? 27.625 13.904 2.373   1.000 24.770 0  35   ASP A CB  1 ? 
ATOM   282  C CG  . ASP A 1 35  ? 27.541 12.977 3.579   1.000 29.460 0  35   ASP A CG  1 ? 
ATOM   283  O OD1 . ASP A 1 35  ? 26.713 12.041 3.546   1.000 28.390 0  35   ASP A OD1 1 ? 
ATOM   284  O OD2 . ASP A 1 35  ? 28.211 13.287 4.594   1.000 27.460 0  35   ASP A OD2 1 ? 
ATOM   285  N N   . LYS A 1 36  ? 25.864 11.386 0.598   1.000 20.680 0  36   LYS A N   1 ? 
ATOM   286  C CA  . LYS A 1 36  ? 26.094 10.029 0.129   1.000 21.620 0  36   LYS A CA  1 ? 
ATOM   287  C C   . LYS A 1 36  ? 25.997 9.866  -1.393  1.000 22.680 0  36   LYS A C   1 ? 
ATOM   288  O O   . LYS A 1 36  ? 26.636 8.969  -1.954  1.000 19.740 0  36   LYS A O   1 ? 
ATOM   289  C CB  . LYS A 1 36  ? 25.167 9.089  0.887   1.000 24.250 0  36   LYS A CB  1 ? 
ATOM   290  C CG  . LYS A 1 36  ? 25.552 8.885  2.352   1.000 27.480 0  36   LYS A CG  1 ? 
ATOM   291  C CD  . LYS A 1 36  ? 24.588 7.871  2.936   1.000 33.260 0  36   LYS A CD  1 ? 
ATOM   292  C CE  . LYS A 1 36  ? 24.626 7.785  4.429   1.000 39.770 0  36   LYS A CE  1 ? 
ATOM   293  N NZ  . LYS A 1 36  ? 25.998 7.693  4.904   1.000 43.140 0  36   LYS A NZ  1 ? 
ATOM   294  N N   . PHE A 1 37  ? 25.199 10.709 -2.053  1.000 18.950 0  37   PHE A N   1 ? 
ATOM   295  C CA  . PHE A 1 37  ? 24.974 10.594 -3.484  1.000 20.590 0  37   PHE A CA  1 ? 
ATOM   296  C C   . PHE A 1 37  ? 24.806 11.960 -4.130  1.000 19.230 0  37   PHE A C   1 ? 
ATOM   297  O O   . PHE A 1 37  ? 24.282 12.888 -3.525  1.000 20.080 0  37   PHE A O   1 ? 
ATOM   298  C CB  . PHE A 1 37  ? 23.690 9.824  -3.826  1.000 19.520 0  37   PHE A CB  1 ? 
ATOM   299  C CG  . PHE A 1 37  ? 23.661 8.403  -3.288  1.000 22.550 0  37   PHE A CG  1 ? 
ATOM   300  C CD1 . PHE A 1 37  ? 24.316 7.379  -3.960  1.000 24.950 0  37   PHE A CD1 1 ? 
ATOM   301  C CD2 . PHE A 1 37  ? 23.035 8.132  -2.078  1.000 24.000 0  37   PHE A CD2 1 ? 
ATOM   302  C CE1 . PHE A 1 37  ? 24.350 6.104  -3.413  1.000 27.250 0  37   PHE A CE1 1 ? 
ATOM   303  C CE2 . PHE A 1 37  ? 23.033 6.852  -1.551  1.000 30.070 0  37   PHE A CE2 1 ? 
ATOM   304  C CZ  . PHE A 1 37  ? 23.713 5.847  -2.209  1.000 30.150 0  37   PHE A CZ  1 ? 
ATOM   305  N N   . ILE A 1 38  ? 25.156 12.007 -5.415  1.000 19.470 0  38   ILE A N   1 ? 
ATOM   306  C CA  . ILE A 1 38  ? 24.807 13.096 -6.308  1.000 20.250 0  38   ILE A CA  1 ? 
ATOM   307  C C   . ILE A 1 38  ? 24.070 12.498 -7.502  1.000 21.640 0  38   ILE A C   1 ? 
ATOM   308  O O   . ILE A 1 38  ? 24.555 11.500 -8.034  1.000 20.170 0  38   ILE A O   1 ? 
ATOM   309  C CB  . ILE A 1 38  ? 26.071 13.868 -6.725  1.000 21.060 0  38   ILE A CB  1 ? 
ATOM   310  C CG1 . ILE A 1 38  ? 26.727 14.545 -5.553  1.000 20.420 0  38   ILE A CG1 1 ? 
ATOM   311  C CG2 . ILE A 1 38  ? 25.753 14.885 -7.814  1.000 21.040 0  38   ILE A CG2 1 ? 
ATOM   312  C CD1 . ILE A 1 38  ? 28.024 15.256 -5.879  1.000 19.920 0  38   ILE A CD1 1 ? 
ATOM   313  N N   . CYS A 1 39  ? 22.910 13.057 -7.879  1.000 19.900 0  39   CYS A N   1 ? 
ATOM   314  C CA  . CYS A 1 39  ? 22.214 12.634 -9.090  1.000 20.140 0  39   CYS A CA  1 ? 
ATOM   315  C C   . CYS A 1 39  ? 22.218 13.779 -10.097 1.000 19.540 0  39   CYS A C   1 ? 
ATOM   316  O O   . CYS A 1 39  ? 21.863 14.908 -9.763  1.000 19.620 0  39   CYS A O   1 ? 
ATOM   317  C CB  . CYS A 1 39  ? 20.749 12.274 -8.885  1.000 24.640 0  39   CYS A CB  1 ? 
ATOM   318  S SG  . CYS A 1 39  ? 20.568 10.845 -7.801  1.000 30.530 0  39   CYS A SG  1 ? 
ATOM   319  N N   . ILE A 1 40  ? 22.585 13.470 -11.337 1.000 18.550 0  40   ILE A N   1 ? 
ATOM   320  C CA  . ILE A 1 40  ? 22.585 14.436 -12.419 1.000 20.410 0  40   ILE A CA  1 ? 
ATOM   321  C C   . ILE A 1 40  ? 21.702 13.931 -13.549 1.000 19.260 0  40   ILE A C   1 ? 
ATOM   322  O O   . ILE A 1 40  ? 21.955 12.847 -14.053 1.000 21.710 0  40   ILE A O   1 ? 
ATOM   323  C CB  . ILE A 1 40  ? 24.006 14.743 -12.935 1.000 21.690 0  40   ILE A CB  1 ? 
ATOM   324  C CG1 . ILE A 1 40  ? 24.993 15.099 -11.817 1.000 25.070 0  40   ILE A CG1 1 ? 
ATOM   325  C CG2 . ILE A 1 40  ? 23.934 15.868 -13.970 1.000 21.010 0  40   ILE A CG2 1 ? 
ATOM   326  C CD1 . ILE A 1 40  ? 25.846 13.951 -11.343 1.000 30.510 0  40   ILE A CD1 1 ? 
ATOM   327  N N   . ARG A 1 41  ? 20.724 14.747 -13.951 1.000 18.830 0  41   ARG A N   1 ? 
ATOM   328  C CA  . ARG A 1 41  ? 19.907 14.489 -15.131 1.000 21.710 0  41   ARG A CA  1 ? 
ATOM   329  C C   . ARG A 1 41  ? 20.647 15.007 -16.361 1.000 22.640 0  41   ARG A C   1 ? 
ATOM   330  O O   . ARG A 1 41  ? 21.091 16.132 -16.361 1.000 21.430 0  41   ARG A O   1 ? 
ATOM   331  C CB  . ARG A 1 41  ? 18.491 15.057 -15.028 1.000 20.770 0  41   ARG A CB  1 ? 
ATOM   332  C CG  . ARG A 1 41  ? 17.684 14.461 -13.887 1.000 23.040 0  41   ARG A CG  1 ? 
ATOM   333  C CD  . ARG A 1 41  ? 16.241 14.906 -13.886 1.000 25.070 0  41   ARG A CD  1 ? 
ATOM   334  N NE  . ARG A 1 41  ? 16.177 16.372 -13.797 1.000 25.970 0  41   ARG A NE  1 ? 
ATOM   335  C CZ  . ARG A 1 41  ? 15.844 17.185 -14.767 1.000 28.060 0  41   ARG A CZ  1 ? 
ATOM   336  N NH1 . ARG A 1 41  ? 15.413 16.711 -15.915 1.000 30.490 0  41   ARG A NH1 1 ? 
ATOM   337  N NH2 . ARG A 1 41  ? 15.913 18.475 -14.584 1.000 27.590 0  41   ARG A NH2 1 ? 
ATOM   338  N N   . GLU A 1 42  ? 20.780 14.182 -17.408 1.000 25.190 0  42   GLU A N   1 ? 
ATOM   339  C CA  . GLU A 1 42  ? 21.504 14.580 -18.612 1.000 29.870 0  42   GLU A CA  1 ? 
ATOM   340  C C   . GLU A 1 42  ? 20.772 13.988 -19.815 1.000 37.910 0  42   GLU A C   1 ? 
ATOM   341  O O   . GLU A 1 42  ? 19.984 13.059 -19.658 1.000 34.130 0  42   GLU A O   1 ? 
ATOM   342  C CB  . GLU A 1 42  ? 22.991 14.222 -18.476 1.000 36.980 0  42   GLU A CB  1 ? 
ATOM   343  C CG  . GLU A 1 42  ? 23.374 12.760 -18.673 1.000 42.160 0  42   GLU A CG  1 ? 
ATOM   344  C CD  . GLU A 1 42  ? 24.872 12.415 -18.536 1.000 49.310 0  42   GLU A CD  1 ? 
ATOM   345  O OE1 . GLU A 1 42  ? 25.722 13.281 -18.139 1.000 38.550 0  42   GLU A OE1 1 ? 
ATOM   346  O OE2 . GLU A 1 42  ? 25.200 11.216 -18.830 1.000 55.810 0  42   GLU A OE2 1 ? 
ATOM   347  N N   A LYS A 1 43  ? 21.004 14.555 -21.004 0.300 39.530 0  43   LYS A N   1 ? 
ATOM   348  N N   B LYS A 1 43  ? 20.991 14.589 -20.990 0.700 43.070 0  43   LYS A N   1 ? 
ATOM   349  C CA  A LYS A 1 43  ? 20.430 14.022 -22.231 0.300 41.400 0  43   LYS A CA  1 ? 
ATOM   350  C CA  B LYS A 1 43  ? 20.461 14.085 -22.248 0.700 46.100 0  43   LYS A CA  1 ? 
ATOM   351  C C   A LYS A 1 43  ? 21.565 13.722 -23.202 0.300 45.960 0  43   LYS A C   1 ? 
ATOM   352  C C   B LYS A 1 43  ? 21.645 13.725 -23.134 0.700 49.690 0  43   LYS A C   1 ? 
ATOM   353  O O   A LYS A 1 43  ? 22.175 14.647 -23.732 0.300 47.190 0  43   LYS A O   1 ? 
ATOM   354  O O   B LYS A 1 43  ? 22.402 14.618 -23.500 0.700 49.710 0  43   LYS A O   1 ? 
ATOM   355  C CB  A LYS A 1 43  ? 19.399 14.961 -22.862 0.300 40.170 0  43   LYS A CB  1 ? 
ATOM   356  C CB  B LYS A 1 43  ? 19.603 15.127 -22.964 0.700 48.080 0  43   LYS A CB  1 ? 
ATOM   357  C CG  A LYS A 1 43  ? 18.570 14.335 -23.981 0.300 39.200 0  43   LYS A CG  1 ? 
ATOM   358  C CG  B LYS A 1 43  ? 18.365 15.544 -22.194 0.700 52.220 0  43   LYS A CG  1 ? 
ATOM   359  C CD  A LYS A 1 43  ? 17.169 14.926 -24.092 0.300 40.170 0  43   LYS A CD  1 ? 
ATOM   360  C CD  B LYS A 1 43  ? 17.640 16.731 -22.815 0.700 54.880 0  43   LYS A CD  1 ? 
ATOM   361  C CE  A LYS A 1 43  ? 16.511 15.006 -22.744 0.300 41.360 0  43   LYS A CE  1 ? 
ATOM   362  C CE  B LYS A 1 43  ? 16.513 17.212 -21.951 0.700 58.720 0  43   LYS A CE  1 ? 
ATOM   363  N NZ  A LYS A 1 43  ? 15.105 15.429 -22.773 0.300 40.460 0  43   LYS A NZ  1 ? 
ATOM   364  N NZ  B LYS A 1 43  ? 16.031 18.536 -22.357 0.700 57.870 0  43   LYS A NZ  1 ? 
ATOM   365  N N   . VAL A 1 44  ? 21.821 12.421 -23.406 1.000 48.650 0  44   VAL A N   1 ? 
ATOM   366  C CA  . VAL A 1 44  ? 22.931 11.924 -24.209 1.000 54.590 0  44   VAL A CA  1 ? 
ATOM   367  C C   . VAL A 1 44  ? 22.334 11.152 -25.383 1.000 55.770 0  44   VAL A C   1 ? 
ATOM   368  O O   . VAL A 1 44  ? 21.765 10.082 -25.198 1.000 54.730 0  44   VAL A O   1 ? 
ATOM   369  C CB  . VAL A 1 44  ? 23.903 11.048 -23.387 1.000 57.930 0  44   VAL A CB  1 ? 
ATOM   370  C CG1 . VAL A 1 44  ? 24.990 10.428 -24.255 1.000 58.200 0  44   VAL A CG1 1 ? 
ATOM   371  C CG2 . VAL A 1 44  ? 24.537 11.823 -22.230 1.000 58.840 0  44   VAL A CG2 1 ? 
ATOM   372  N N   . GLY A 1 45  ? 22.484 11.710 -26.589 1.000 65.490 0  45   GLY A N   1 ? 
ATOM   373  C CA  . GLY A 1 45  ? 21.661 11.334 -27.727 1.000 65.040 0  45   GLY A CA  1 ? 
ATOM   374  C C   . GLY A 1 45  ? 20.298 12.000 -27.595 1.000 66.190 0  45   GLY A C   1 ? 
ATOM   375  O O   . GLY A 1 45  ? 20.199 13.119 -27.089 1.000 67.470 0  45   GLY A O   1 ? 
ATOM   376  N N   . GLU A 1 46  ? 19.246 11.290 -28.007 1.000 62.420 0  46   GLU A N   1 ? 
ATOM   377  C CA  . GLU A 1 46  ? 17.895 11.720 -27.681 1.000 63.100 0  46   GLU A CA  1 ? 
ATOM   378  C C   . GLU A 1 46  ? 17.405 11.068 -26.378 1.000 50.930 0  46   GLU A C   1 ? 
ATOM   379  O O   . GLU A 1 46  ? 16.226 11.199 -26.035 1.000 45.010 0  46   GLU A O   1 ? 
ATOM   380  C CB  . GLU A 1 46  ? 16.953 11.397 -28.841 1.000 72.150 0  46   GLU A CB  1 ? 
ATOM   381  C CG  . GLU A 1 46  ? 17.278 12.149 -30.128 1.000 73.890 0  46   GLU A CG  1 ? 
ATOM   382  C CD  . GLU A 1 46  ? 16.288 11.883 -31.252 1.000 81.040 0  46   GLU A CD  1 ? 
ATOM   383  O OE1 . GLU A 1 46  ? 16.541 12.377 -32.371 1.000 83.200 0  46   GLU A OE1 1 ? 
ATOM   384  O OE2 . GLU A 1 46  ? 15.262 11.196 -31.026 1.000 86.000 0  46   GLU A OE2 1 ? 
ATOM   385  N N   A GLN A 1 47  ? 18.273 10.343 -25.654 0.680 47.580 0  47   GLN A N   1 ? 
ATOM   386  N N   B GLN A 1 47  ? 18.340 10.447 -25.647 0.320 46.010 0  47   GLN A N   1 ? 
ATOM   387  C CA  A GLN A 1 47  ? 17.810 9.628  -24.468 0.680 43.000 0  47   GLN A CA  1 ? 
ATOM   388  C CA  B GLN A 1 47  ? 18.055 9.679  -24.446 0.320 41.960 0  47   GLN A CA  1 ? 
ATOM   389  C C   A GLN A 1 47  ? 18.191 10.397 -23.199 0.680 39.160 0  47   GLN A C   1 ? 
ATOM   390  C C   B GLN A 1 47  ? 18.228 10.567 -23.213 0.320 37.770 0  47   GLN A C   1 ? 
ATOM   391  O O   A GLN A 1 47  ? 19.375 10.591 -22.907 0.680 38.890 0  47   GLN A O   1 ? 
ATOM   392  O O   B GLN A 1 47  ? 19.322 11.078 -22.983 0.320 38.130 0  47   GLN A O   1 ? 
ATOM   393  C CB  A GLN A 1 47  ? 18.275 8.170  -24.408 0.680 46.200 0  47   GLN A CB  1 ? 
ATOM   394  C CB  B GLN A 1 47  ? 19.071 8.535  -24.460 0.320 42.230 0  47   GLN A CB  1 ? 
ATOM   395  C CG  A GLN A 1 47  ? 17.693 7.353  -23.250 0.680 42.870 0  47   GLN A CG  1 ? 
ATOM   396  C CG  B GLN A 1 47  ? 18.913 7.496  -23.354 0.320 43.160 0  47   GLN A CG  1 ? 
ATOM   397  C CD  A GLN A 1 47  ? 16.180 7.396  -23.144 0.680 42.410 0  47   GLN A CD  1 ? 
ATOM   398  C CD  B GLN A 1 47  ? 19.810 6.298  -23.569 0.320 43.490 0  47   GLN A CD  1 ? 
ATOM   399  O OE1 A GLN A 1 47  ? 15.451 7.153  -24.119 0.680 44.750 0  47   GLN A OE1 1 ? 
ATOM   400  O OE1 B GLN A 1 47  ? 20.430 6.143  -24.629 0.320 45.210 0  47   GLN A OE1 1 ? 
ATOM   401  N NE2 A GLN A 1 47  ? 15.682 7.699  -21.950 0.680 35.310 0  47   GLN A NE2 1 ? 
ATOM   402  N NE2 B GLN A 1 47  ? 19.881 5.432  -22.570 0.320 42.400 0  47   GLN A NE2 1 ? 
ATOM   403  N N   . ALA A 1 48  ? 17.159 10.753 -22.428 1.000 33.380 0  48   ALA A N   1 ? 
ATOM   404  C CA  . ALA A 1 48  ? 17.307 11.321 -21.094 1.000 31.970 0  48   ALA A CA  1 ? 
ATOM   405  C C   . ALA A 1 48  ? 17.812 10.240 -20.144 1.000 29.950 0  48   ALA A C   1 ? 
ATOM   406  O O   . ALA A 1 48  ? 17.425 9.068  -20.233 1.000 25.610 0  48   ALA A O   1 ? 
ATOM   407  C CB  . ALA A 1 48  ? 16.014 11.909 -20.623 1.000 30.910 0  48   ALA A CB  1 ? 
ATOM   408  N N   . GLN A 1 49  ? 18.746 10.623 -19.269 1.000 24.340 0  49   GLN A N   1 ? 
ATOM   409  C CA  . GLN A 1 49  ? 19.349 9.675  -18.365 1.000 26.040 0  49   GLN A CA  1 ? 
ATOM   410  C C   . GLN A 1 49  ? 19.541 10.365 -17.018 1.000 26.410 0  49   GLN A C   1 ? 
ATOM   411  O O   . GLN A 1 49  ? 19.520 11.585 -16.956 1.000 26.120 0  49   GLN A O   1 ? 
ATOM   412  C CB  . GLN A 1 49  ? 20.753 9.204  -18.742 1.000 31.340 0  49   GLN A CB  1 ? 
ATOM   413  C CG  . GLN A 1 49  ? 20.987 9.002  -20.232 1.000 39.810 0  49   GLN A CG  1 ? 
ATOM   414  C CD  . GLN A 1 49  ? 22.366 8.456  -20.529 1.000 40.630 0  49   GLN A CD  1 ? 
ATOM   415  O OE1 . GLN A 1 49  ? 23.384 8.864  -19.956 1.000 43.040 0  49   GLN A OE1 1 ? 
ATOM   416  N NE2 . GLN A 1 49  ? 22.401 7.491  -21.428 1.000 44.890 0  49   GLN A NE2 1 ? 
ATOM   417  N N   . VAL A 1 50  ? 19.701 9.554  -15.978 1.000 22.850 0  50   VAL A N   1 ? 
ATOM   418  C CA  . VAL A 1 50  ? 20.259 10.048 -14.727 1.000 21.980 0  50   VAL A CA  1 ? 
ATOM   419  C C   . VAL A 1 50  ? 21.584 9.346  -14.465 1.000 23.270 0  50   VAL A C   1 ? 
ATOM   420  O O   . VAL A 1 50  ? 21.769 8.182  -14.803 1.000 24.130 0  50   VAL A O   1 ? 
ATOM   421  C CB  . VAL A 1 50  ? 19.240 9.842  -13.588 1.000 22.710 0  50   VAL A CB  1 ? 
ATOM   422  C CG1 . VAL A 1 50  ? 19.115 8.373  -13.203 1.000 21.850 0  50   VAL A CG1 1 ? 
ATOM   423  C CG2 . VAL A 1 50  ? 19.648 10.679 -12.383 1.000 23.910 0  50   VAL A CG2 1 ? 
ATOM   424  N N   . VAL A 1 51  ? 22.528 10.108 -13.914 1.000 19.410 0  51   VAL A N   1 ? 
ATOM   425  C CA  . VAL A 1 51  ? 23.827 9.667  -13.506 1.000 21.860 0  51   VAL A CA  1 ? 
ATOM   426  C C   . VAL A 1 51  ? 23.812 9.721  -11.992 1.000 23.170 0  51   VAL A C   1 ? 
ATOM   427  O O   . VAL A 1 51  ? 23.538 10.769 -11.418 1.000 22.540 0  51   VAL A O   1 ? 
ATOM   428  C CB  . VAL A 1 51  ? 24.976 10.535 -14.043 1.000 24.490 0  51   VAL A CB  1 ? 
ATOM   429  C CG1 . VAL A 1 51  ? 26.309 9.978  -13.609 1.000 26.720 0  51   VAL A CG1 1 ? 
ATOM   430  C CG2 . VAL A 1 51  ? 24.875 10.734 -15.564 1.000 27.140 0  51   VAL A CG2 1 ? 
ATOM   431  N N   . ILE A 1 52  ? 24.110 8.584  -11.376 1.000 22.270 0  52   ILE A N   1 ? 
ATOM   432  C CA  . ILE A 1 52  ? 24.054 8.454  -9.936  1.000 24.370 0  52   ILE A CA  1 ? 
ATOM   433  C C   . ILE A 1 52  ? 25.469 8.206  -9.478  1.000 24.450 0  52   ILE A C   1 ? 
ATOM   434  O O   . ILE A 1 52  ? 26.079 7.200  -9.843  1.000 24.740 0  52   ILE A O   1 ? 
ATOM   435  C CB  . ILE A 1 52  ? 23.114 7.322  -9.501  1.000 25.070 0  52   ILE A CB  1 ? 
ATOM   436  C CG1 . ILE A 1 52  ? 21.692 7.582  -9.963  1.000 25.320 0  52   ILE A CG1 1 ? 
ATOM   437  C CG2 . ILE A 1 52  ? 23.237 7.113  -7.992  1.000 26.940 0  52   ILE A CG2 1 ? 
ATOM   438  C CD1 . ILE A 1 52  ? 20.735 6.409  -9.820  1.000 28.840 0  52   ILE A CD1 1 ? 
ATOM   439  N N   . ILE A 1 53  ? 25.993 9.157  -8.706  1.000 22.590 0  53   ILE A N   1 ? 
ATOM   440  C CA  . ILE A 1 53  ? 27.333 9.060  -8.181  1.000 22.140 0  53   ILE A CA  1 ? 
ATOM   441  C C   . ILE A 1 53  ? 27.241 8.679  -6.725  1.000 24.560 0  53   ILE A C   1 ? 
ATOM   442  O O   . ILE A 1 53  ? 26.672 9.405  -5.915  1.000 22.850 0  53   ILE A O   1 ? 
ATOM   443  C CB  . ILE A 1 53  ? 28.086 10.373 -8.400  1.000 25.710 0  53   ILE A CB  1 ? 
ATOM   444  C CG1 . ILE A 1 53  ? 28.176 10.664 -9.859  1.000 30.630 0  53   ILE A CG1 1 ? 
ATOM   445  C CG2 . ILE A 1 53  ? 29.450 10.328 -7.716  1.000 24.670 0  53   ILE A CG2 1 ? 
ATOM   446  C CD1 . ILE A 1 53  ? 28.406 12.105 -10.186 1.000 31.380 0  53   ILE A CD1 1 ? 
ATOM   447  N N   . ASP A 1 54  ? 27.807 7.512  -6.418  1.000 25.060 0  54   ASP A N   1 ? 
ATOM   448  C CA  . ASP A 1 54  ? 27.925 7.046  -5.061  1.000 26.350 0  54   ASP A CA  1 ? 
ATOM   449  C C   . ASP A 1 54  ? 29.189 7.661  -4.510  1.000 26.100 0  54   ASP A C   1 ? 
ATOM   450  O O   . ASP A 1 54  ? 30.273 7.366  -5.002  1.000 25.540 0  54   ASP A O   1 ? 
ATOM   451  C CB  . ASP A 1 54  ? 28.042 5.532  -5.034  1.000 29.940 0  54   ASP A CB  1 ? 
ATOM   452  C CG  . ASP A 1 54  ? 28.080 4.881  -3.656  1.000 33.640 0  54   ASP A CG  1 ? 
ATOM   453  O OD1 . ASP A 1 54  ? 28.632 5.498  -2.713  1.000 31.940 0  54   ASP A OD1 1 ? 
ATOM   454  O OD2 . ASP A 1 54  ? 27.593 3.727  -3.559  1.000 37.860 0  54   ASP A OD2 1 ? 
ATOM   455  N N   . MET A 1 55  ? 29.063 8.471  -3.452  1.000 25.510 0  55   MET A N   1 ? 
ATOM   456  C CA  . MET A 1 55  ? 30.226 9.203  -2.978  1.000 25.790 0  55   MET A CA  1 ? 
ATOM   457  C C   . MET A 1 55  ? 31.206 8.275  -2.264  1.000 28.060 0  55   MET A C   1 ? 
ATOM   458  O O   . MET A 1 55  ? 32.321 8.693  -2.020  1.000 34.160 0  55   MET A O   1 ? 
ATOM   459  C CB  . MET A 1 55  ? 29.830 10.370 -2.062  1.000 27.550 0  55   MET A CB  1 ? 
ATOM   460  C CG  . MET A 1 55  ? 28.981 11.389 -2.780  1.000 28.670 0  55   MET A CG  1 ? 
ATOM   461  S SD  . MET A 1 55  ? 29.869 12.172 -4.143  1.000 35.880 0  55   MET A SD  1 ? 
ATOM   462  C CE  . MET A 1 55  ? 31.173 13.041 -3.273  1.000 34.750 0  55   MET A CE  1 ? 
ATOM   463  N N   . ASN A 1 56  ? 30.811 7.041  -1.947  1.000 32.910 0  56   ASN A N   1 ? 
ATOM   464  C CA  . ASN A 1 56  ? 31.769 6.071  -1.444  1.000 40.370 0  56   ASN A CA  1 ? 
ATOM   465  C C   . ASN A 1 56  ? 32.515 5.355  -2.561  1.000 40.950 0  56   ASN A C   1 ? 
ATOM   466  O O   . ASN A 1 56  ? 33.481 4.665  -2.266  1.000 48.950 0  56   ASN A O   1 ? 
ATOM   467  C CB  . ASN A 1 56  ? 31.142 4.968  -0.613  1.000 46.000 0  56   ASN A CB  1 ? 
ATOM   468  C CG  . ASN A 1 56  ? 30.874 5.432  0.789   1.000 57.350 0  56   ASN A CG  1 ? 
ATOM   469  O OD1 . ASN A 1 56  ? 31.604 6.288  1.315   1.000 60.130 0  56   ASN A OD1 1 ? 
ATOM   470  N ND2 . ASN A 1 56  ? 29.819 4.897  1.384   1.000 66.570 0  56   ASN A ND2 1 ? 
ATOM   471  N N   . ASP A 1 57  ? 32.080 5.512  -3.815  1.000 39.360 0  57   ASP A N   1 ? 
ATOM   472  C CA  . ASP A 1 57  ? 32.669 4.798  -4.943  1.000 38.840 0  57   ASP A CA  1 ? 
ATOM   473  C C   . ASP A 1 57  ? 32.517 5.661  -6.190  1.000 32.530 0  57   ASP A C   1 ? 
ATOM   474  O O   . ASP A 1 57  ? 31.919 5.268  -7.193  1.000 32.050 0  57   ASP A O   1 ? 
ATOM   475  C CB  . ASP A 1 57  ? 32.004 3.440  -5.122  1.000 41.100 0  57   ASP A CB  1 ? 
ATOM   476  C CG  . ASP A 1 57  ? 32.558 2.573  -6.249  1.000 45.550 0  57   ASP A CG  1 ? 
ATOM   477  O OD1 . ASP A 1 57  ? 33.676 2.896  -6.726  1.000 49.030 0  57   ASP A OD1 1 ? 
ATOM   478  O OD2 . ASP A 1 57  ? 31.836 1.623  -6.673  1.000 44.440 0  57   ASP A OD2 1 ? 
ATOM   479  N N   . PRO A 1 58  ? 33.045 6.887  -6.155  1.000 32.860 0  58   PRO A N   1 ? 
ATOM   480  C CA  . PRO A 1 58  ? 32.621 7.928  -7.093  1.000 35.760 0  58   PRO A CA  1 ? 
ATOM   481  C C   . PRO A 1 58  ? 33.129 7.758  -8.519  1.000 38.860 0  58   PRO A C   1 ? 
ATOM   482  O O   . PRO A 1 58  ? 32.606 8.388  -9.427  1.000 42.400 0  58   PRO A O   1 ? 
ATOM   483  C CB  . PRO A 1 58  ? 33.188 9.187  -6.445  1.000 36.540 0  58   PRO A CB  1 ? 
ATOM   484  C CG  . PRO A 1 58  ? 34.413 8.694  -5.756  1.000 35.790 0  58   PRO A CG  1 ? 
ATOM   485  C CD  . PRO A 1 58  ? 34.067 7.338  -5.199  1.000 35.190 0  58   PRO A CD  1 ? 
ATOM   486  N N   . SER A 1 59  ? 34.125 6.893  -8.716  1.000 39.810 0  59   SER A N   1 ? 
ATOM   487  C CA  . SER A 1 59  ? 34.669 6.718  -10.048 1.000 44.420 0  59   SER A CA  1 ? 
ATOM   488  C C   . SER A 1 59  ? 33.840 5.715  -10.839 1.000 42.590 0  59   SER A C   1 ? 
ATOM   489  O O   . SER A 1 59  ? 34.090 5.540  -12.021 1.000 51.040 0  59   SER A O   1 ? 
ATOM   490  C CB  . SER A 1 59  ? 36.125 6.315  -9.998  1.000 50.590 0  59   SER A CB  1 ? 
ATOM   491  O OG  . SER A 1 59  ? 36.275 5.073  -9.325  1.000 55.320 0  59   SER A OG  1 ? 
ATOM   492  N N   . ASN A 1 60  ? 32.858 5.057  -10.205 1.000 41.570 0  60   ASN A N   1 ? 
ATOM   493  C CA  . ASN A 1 60  ? 32.024 4.095  -10.911 1.000 42.020 0  60   ASN A CA  1 ? 
ATOM   494  C C   . ASN A 1 60  ? 30.560 4.519  -10.872 1.000 33.720 0  60   ASN A C   1 ? 
ATOM   495  O O   . ASN A 1 60  ? 29.717 3.794  -10.384 1.000 36.840 0  60   ASN A O   1 ? 
ATOM   496  C CB  . ASN A 1 60  ? 32.209 2.677  -10.383 1.000 45.920 0  60   ASN A CB  1 ? 
ATOM   497  C CG  . ASN A 1 60  ? 33.653 2.236  -10.459 1.000 49.980 0  60   ASN A CG  1 ? 
ATOM   498  O OD1 . ASN A 1 60  ? 34.307 2.391  -11.501 1.000 56.810 0  60   ASN A OD1 1 ? 
ATOM   499  N ND2 . ASN A 1 60  ? 34.182 1.732  -9.353  1.000 52.280 0  60   ASN A ND2 1 ? 
ATOM   500  N N   . PRO A 1 61  ? 30.187 5.658  -11.478 1.000 31.760 0  61   PRO A N   1 ? 
ATOM   501  C CA  . PRO A 1 61  ? 28.781 6.060  -11.513 1.000 32.210 0  61   PRO A CA  1 ? 
ATOM   502  C C   . PRO A 1 61  ? 27.937 5.135  -12.374 1.000 35.010 0  61   PRO A C   1 ? 
ATOM   503  O O   . PRO A 1 61  ? 28.432 4.535  -13.324 1.000 34.500 0  61   PRO A O   1 ? 
ATOM   504  C CB  . PRO A 1 61  ? 28.882 7.440  -12.116 1.000 33.210 0  61   PRO A CB  1 ? 
ATOM   505  C CG  . PRO A 1 61  ? 30.060 7.315  -13.056 1.000 35.070 0  61   PRO A CG  1 ? 
ATOM   506  C CD  . PRO A 1 61  ? 31.064 6.576  -12.214 1.000 32.670 0  61   PRO A CD  1 ? 
ATOM   507  N N   . ILE A 1 62  ? 26.658 5.069  -12.039 1.000 32.800 0  62   ILE A N   1 ? 
ATOM   508  C CA  . ILE A 1 62  ? 25.667 4.336  -12.801 1.000 36.850 0  62   ILE A CA  1 ? 
ATOM   509  C C   . ILE A 1 62  ? 24.895 5.348  -13.647 1.000 37.780 0  62   ILE A C   1 ? 
ATOM   510  O O   . ILE A 1 62  ? 24.531 6.427  -13.176 1.000 30.210 0  62   ILE A O   1 ? 
ATOM   511  C CB  . ILE A 1 62  ? 24.767 3.562  -11.820 1.000 46.590 0  62   ILE A CB  1 ? 
ATOM   512  C CG1 . ILE A 1 62  ? 23.615 2.858  -12.471 1.000 52.070 0  62   ILE A CG1 1 ? 
ATOM   513  C CG2 . ILE A 1 62  ? 24.227 4.476  -10.729 1.000 47.610 0  62   ILE A CG2 1 ? 
ATOM   514  C CD1 . ILE A 1 62  ? 22.515 2.481  -11.486 1.000 54.700 0  62   ILE A CD1 1 ? 
ATOM   515  N N   . ARG A 1 63  ? 24.631 4.994  -14.902 1.000 30.040 0  63   ARG A N   1 ? 
ATOM   516  C CA  . ARG A 1 63  ? 23.750 5.777  -15.732 1.000 28.520 0  63   ARG A CA  1 ? 
ATOM   517  C C   . ARG A 1 63  ? 22.544 4.943  -16.143 1.000 29.260 0  63   ARG A C   1 ? 
ATOM   518  O O   . ARG A 1 63  ? 22.685 3.806  -16.583 1.000 29.240 0  63   ARG A O   1 ? 
ATOM   519  C CB  . ARG A 1 63  ? 24.463 6.211  -17.011 1.000 32.390 0  63   ARG A CB  1 ? 
ATOM   520  C CG  . ARG A 1 63  ? 25.649 7.134  -16.830 1.000 40.130 0  63   ARG A CG  1 ? 
ATOM   521  C CD  . ARG A 1 63  ? 26.118 7.566  -18.219 1.000 43.120 0  63   ARG A CD  1 ? 
ATOM   522  N NE  . ARG A 1 63  ? 26.543 8.967  -18.228 1.000 45.910 0  63   ARG A NE  1 ? 
ATOM   523  C CZ  . ARG A 1 63  ? 27.616 9.461  -17.628 1.000 52.010 0  63   ARG A CZ  1 ? 
ATOM   524  N NH1 . ARG A 1 63  ? 28.436 8.680  -16.928 1.000 48.220 0  63   ARG A NH1 1 ? 
ATOM   525  N NH2 . ARG A 1 63  ? 27.853 10.761 -17.741 1.000 55.500 0  63   ARG A NH2 1 ? 
ATOM   526  N N   . ARG A 1 64  ? 21.357 5.516  -16.002 1.000 23.990 0  64   ARG A N   1 ? 
ATOM   527  C CA  . ARG A 1 64  ? 20.139 4.823  -16.326 1.000 25.470 0  64   ARG A CA  1 ? 
ATOM   528  C C   . ARG A 1 64  ? 19.227 5.733  -17.115 1.000 25.340 0  64   ARG A C   1 ? 
ATOM   529  O O   . ARG A 1 64  ? 19.112 6.914  -16.792 1.000 25.100 0  64   ARG A O   1 ? 
ATOM   530  C CB  . ARG A 1 64  ? 19.436 4.375  -15.043 1.000 24.750 0  64   ARG A CB  1 ? 
ATOM   531  C CG  . ARG A 1 64  ? 20.138 3.259  -14.303 1.000 27.350 0  64   ARG A CG  1 ? 
ATOM   532  C CD  . ARG A 1 64  ? 20.290 1.961  -15.129 1.000 29.850 0  64   ARG A CD  1 ? 
ATOM   533  N NE  . ARG A 1 64  ? 21.025 0.986  -14.307 1.000 32.730 0  64   ARG A NE  1 ? 
ATOM   534  C CZ  . ARG A 1 64  ? 22.327 0.672  -14.362 1.000 34.310 0  64   ARG A CZ  1 ? 
ATOM   535  N NH1 . ARG A 1 64  ? 23.154 1.270  -15.200 1.000 35.250 0  64   ARG A NH1 1 ? 
ATOM   536  N NH2 . ARG A 1 64  ? 22.828 -0.237 -13.543 1.000 33.290 0  64   ARG A NH2 1 ? 
ATOM   537  N N   . PRO A 1 65  ? 18.451 5.182  -18.085 1.000 26.310 0  65   PRO A N   1 ? 
ATOM   538  C CA  . PRO A 1 65  ? 17.423 5.953  -18.767 1.000 25.590 0  65   PRO A CA  1 ? 
ATOM   539  C C   . PRO A 1 65  ? 16.325 6.413  -17.811 1.000 22.830 0  65   PRO A C   1 ? 
ATOM   540  O O   . PRO A 1 65  ? 15.862 5.638  -16.975 1.000 23.940 0  65   PRO A O   1 ? 
ATOM   541  C CB  . PRO A 1 65  ? 16.863 4.944  -19.840 1.000 26.850 0  65   PRO A CB  1 ? 
ATOM   542  C CG  . PRO A 1 65  ? 17.943 3.903  -19.982 1.000 28.080 0  65   PRO A CG  1 ? 
ATOM   543  C CD  . PRO A 1 65  ? 18.554 3.793  -18.592 1.000 29.220 0  65   PRO A CD  1 ? 
ATOM   544  N N   . ILE A 1 66  ? 15.851 7.641  -18.010 1.000 23.210 0  66   ILE A N   1 ? 
ATOM   545  C CA  . ILE A 1 66  ? 14.712 8.143  -17.268 1.000 25.430 0  66   ILE A CA  1 ? 
ATOM   546  C C   . ILE A 1 66  ? 13.787 8.876  -18.216 1.000 24.650 0  66   ILE A C   1 ? 
ATOM   547  O O   . ILE A 1 66  ? 14.211 9.293  -19.291 1.000 24.480 0  66   ILE A O   1 ? 
ATOM   548  C CB  . ILE A 1 66  ? 15.194 9.076  -16.138 1.000 26.240 0  66   ILE A CB  1 ? 
ATOM   549  C CG1 . ILE A 1 66  ? 15.914 10.299 -16.695 1.000 25.660 0  66   ILE A CG1 1 ? 
ATOM   550  C CG2 . ILE A 1 66  ? 16.066 8.305  -15.143 1.000 25.170 0  66   ILE A CG2 1 ? 
ATOM   551  C CD1 . ILE A 1 66  ? 16.144 11.399 -15.659 1.000 26.740 0  66   ILE A CD1 1 ? 
ATOM   552  N N   . SER A 1 67  ? 12.572 9.120  -17.748 1.000 24.810 0  67   SER A N   1 ? 
ATOM   553  C CA  . SER A 1 67  ? 11.691 10.112 -18.337 1.000 25.850 0  67   SER A CA  1 ? 
ATOM   554  C C   . SER A 1 67  ? 11.140 11.058 -17.271 1.000 28.770 0  67   SER A C   1 ? 
ATOM   555  O O   . SER A 1 67  ? 9.981  11.485 -17.333 1.000 31.680 0  67   SER A O   1 ? 
ATOM   556  C CB  . SER A 1 67  ? 10.573 9.420  -19.081 1.000 30.510 0  67   SER A CB  1 ? 
ATOM   557  O OG  . SER A 1 67  ? 10.061 8.388  -18.261 1.000 36.590 0  67   SER A OG  1 ? 
ATOM   558  N N   . ALA A 1 68  ? 11.976 11.399 -16.280 1.000 28.020 0  68   ALA A N   1 ? 
ATOM   559  C CA  . ALA A 1 68  ? 11.539 12.219 -15.155 1.000 26.220 0  68   ALA A CA  1 ? 
ATOM   560  C C   . ALA A 1 68  ? 12.016 13.653 -15.352 1.000 26.190 0  68   ALA A C   1 ? 
ATOM   561  O O   . ALA A 1 68  ? 13.060 13.835 -15.962 1.000 29.180 0  68   ALA A O   1 ? 
ATOM   562  C CB  . ALA A 1 68  ? 12.106 11.625 -13.882 1.000 24.060 0  68   ALA A CB  1 ? 
ATOM   563  N N   . ASP A 1 69  ? 11.279 14.628 -14.796 1.000 24.660 0  69   ASP A N   1 ? 
ATOM   564  C CA  . ASP A 1 69  ? 11.700 16.023 -14.803 1.000 25.070 0  69   ASP A CA  1 ? 
ATOM   565  C C   . ASP A 1 69  ? 12.560 16.345 -13.587 1.000 23.810 0  69   ASP A C   1 ? 
ATOM   566  O O   . ASP A 1 69  ? 13.098 17.450 -13.475 1.000 23.850 0  69   ASP A O   1 ? 
ATOM   567  C CB  . ASP A 1 69  ? 10.522 16.980 -14.901 1.000 25.220 0  69   ASP A CB  1 ? 
ATOM   568  C CG  . ASP A 1 69  ? 9.609  17.074 -13.688 1.000 31.460 0  69   ASP A CG  1 ? 
ATOM   569  O OD1 . ASP A 1 69  ? 10.117 17.031 -12.538 1.000 29.250 0  69   ASP A OD1 1 ? 
ATOM   570  O OD2 . ASP A 1 69  ? 8.384  17.175 -13.892 1.000 30.670 0  69   ASP A OD2 1 ? 
ATOM   571  N N   . SER A 1 70  ? 12.640 15.410 -12.640 1.000 19.230 0  70   SER A N   1 ? 
ATOM   572  C CA  . SER A 1 70  ? 13.402 15.623 -11.422 1.000 19.690 0  70   SER A CA  1 ? 
ATOM   573  C C   . SER A 1 70  ? 13.702 14.276 -10.777 1.000 17.740 0  70   SER A C   1 ? 
ATOM   574  O O   . SER A 1 70  ? 12.851 13.406 -10.764 1.000 19.160 0  70   SER A O   1 ? 
ATOM   575  C CB  . SER A 1 70  ? 12.614 16.526 -10.471 1.000 20.440 0  70   SER A CB  1 ? 
ATOM   576  O OG  . SER A 1 70  ? 13.266 16.674 -9.213  1.000 17.930 0  70   SER A OG  1 ? 
ATOM   577  N N   . ALA A 1 71  ? 14.852 14.156 -10.150 1.000 17.660 0  71   ALA A N   1 ? 
ATOM   578  C CA  . ALA A 1 71  ? 15.347 12.942 -9.502  1.000 17.680 0  71   ALA A CA  1 ? 
ATOM   579  C C   . ALA A 1 71  ? 16.067 13.334 -8.215  1.000 18.450 0  71   ALA A C   1 ? 
ATOM   580  O O   . ALA A 1 71  ? 17.036 14.104 -8.288  1.000 20.860 0  71   ALA A O   1 ? 
ATOM   581  C CB  . ALA A 1 71  ? 16.342 12.252 -10.397 1.000 19.130 0  71   ALA A CB  1 ? 
ATOM   582  N N   . ILE A 1 72  ? 15.633 12.772 -7.071  1.000 17.100 0  72   ILE A N   1 ? 
ATOM   583  C CA  . ILE A 1 72  ? 16.272 13.046 -5.786  1.000 15.410 0  72   ILE A CA  1 ? 
ATOM   584  C C   . ILE A 1 72  ? 16.486 11.723 -5.033  1.000 15.230 0  72   ILE A C   1 ? 
ATOM   585  O O   . ILE A 1 72  ? 15.537 10.968 -4.781  1.000 16.030 0  72   ILE A O   1 ? 
ATOM   586  C CB  . ILE A 1 72  ? 15.462 14.071 -4.945  1.000 16.610 0  72   ILE A CB  1 ? 
ATOM   587  C CG1 . ILE A 1 72  ? 14.001 13.693 -4.777  1.000 18.000 0  72   ILE A CG1 1 ? 
ATOM   588  C CG2 . ILE A 1 72  ? 15.573 15.496 -5.520  1.000 17.240 0  72   ILE A CG2 1 ? 
ATOM   589  C CD1 . ILE A 1 72  ? 13.212 14.531 -3.779  1.000 17.860 0  72   ILE A CD1 1 ? 
ATOM   590  N N   . MET A 1 73  ? 17.725 11.493 -4.635  1.000 16.220 0  73   MET A N   1 ? 
ATOM   591  C CA  . MET A 1 73  ? 18.109 10.296 -3.908  1.000 17.080 0  73   MET A CA  1 ? 
ATOM   592  C C   . MET A 1 73  ? 17.793 10.475 -2.430  1.000 17.630 0  73   MET A C   1 ? 
ATOM   593  O O   . MET A 1 73  ? 17.965 11.542 -1.853  1.000 16.320 0  73   MET A O   1 ? 
ATOM   594  C CB  . MET A 1 73  ? 19.586 9.962  -4.076  1.000 19.000 0  73   MET A CB  1 ? 
ATOM   595  C CG  . MET A 1 73  ? 19.965 8.547  -3.620  1.000 22.520 0  73   MET A CG  1 ? 
ATOM   596  S SD  . MET A 1 73  ? 19.316 7.290  -4.752  1.000 29.100 0  73   MET A SD  1 ? 
ATOM   597  C CE  . MET A 1 73  ? 19.831 8.028  -6.300  1.000 24.890 0  73   MET A CE  1 ? 
ATOM   598  N N   . ASN A 1 74  ? 17.246 9.408  -1.844  1.000 16.760 0  74   ASN A N   1 ? 
ATOM   599  C CA  . ASN A 1 74  ? 17.123 9.287  -0.416  1.000 15.010 0  74   ASN A CA  1 ? 
ATOM   600  C C   . ASN A 1 74  ? 18.447 9.659  0.233   1.000 15.750 0  74   ASN A C   1 ? 
ATOM   601  O O   . ASN A 1 74  ? 19.516 9.342  -0.288  1.000 16.520 0  74   ASN A O   1 ? 
ATOM   602  C CB  . ASN A 1 74  ? 16.696 7.861  -0.054  1.000 16.600 0  74   ASN A CB  1 ? 
ATOM   603  C CG  . ASN A 1 74  ? 16.473 7.681  1.427   1.000 15.840 0  74   ASN A CG  1 ? 
ATOM   604  O OD1 . ASN A 1 74  ? 17.385 7.273  2.160   1.000 18.840 0  74   ASN A OD1 1 ? 
ATOM   605  N ND2 . ASN A 1 74  ? 15.297 8.031  1.890   1.000 16.970 0  74   ASN A ND2 1 ? 
ATOM   606  N N   . PRO A 1 75  ? 18.419 10.344 1.394   1.000 15.840 0  75   PRO A N   1 ? 
ATOM   607  C CA  . PRO A 1 75  ? 19.648 10.696 2.111   1.000 16.440 0  75   PRO A CA  1 ? 
ATOM   608  C C   . PRO A 1 75  ? 20.513 9.528  2.589   1.000 19.430 0  75   PRO A C   1 ? 
ATOM   609  O O   . PRO A 1 75  ? 21.718 9.721  2.752   1.000 18.830 0  75   PRO A O   1 ? 
ATOM   610  C CB  . PRO A 1 75  ? 19.176 11.557 3.312   1.000 18.750 0  75   PRO A CB  1 ? 
ATOM   611  C CG  . PRO A 1 75  ? 17.753 11.920 3.001   1.000 18.500 0  75   PRO A CG  1 ? 
ATOM   612  C CD  . PRO A 1 75  ? 17.209 10.910 2.024   1.000 15.890 0  75   PRO A CD  1 ? 
ATOM   613  N N   . ALA A 1 76  ? 19.943 8.325  2.774   1.000 20.050 0  76   ALA A N   1 ? 
ATOM   614  C CA  . ALA A 1 76  ? 20.710 7.224  3.382   1.000 23.200 0  76   ALA A CA  1 ? 
ATOM   615  C C   . ALA A 1 76  ? 20.803 5.957  2.538   1.000 25.680 0  76   ALA A C   1 ? 
ATOM   616  O O   . ALA A 1 76  ? 21.649 5.101  2.797   1.000 23.310 0  76   ALA A O   1 ? 
ATOM   617  C CB  . ALA A 1 76  ? 20.118 6.899  4.729   1.000 24.480 0  76   ALA A CB  1 ? 
ATOM   618  N N   . SER A 1 77  ? 19.908 5.780  1.582   1.000 24.000 0  77   SER A N   1 ? 
ATOM   619  C CA  . SER A 1 77  ? 19.778 4.501  0.906   1.000 25.920 0  77   SER A CA  1 ? 
ATOM   620  C C   . SER A 1 77  ? 19.706 4.773  -0.586  1.000 24.690 0  77   SER A C   1 ? 
ATOM   621  O O   . SER A 1 77  ? 19.232 5.838  -0.982  1.000 21.030 0  77   SER A O   1 ? 
ATOM   622  C CB  . SER A 1 77  ? 18.546 3.802  1.423   1.000 25.730 0  77   SER A CB  1 ? 
ATOM   623  O OG  . SER A 1 77  ? 18.360 2.494  0.894   1.000 32.320 0  77   SER A OG  1 ? 
ATOM   624  N N   . LYS A 1 78  ? 20.048 3.756  -1.392  1.000 24.040 0  78   LYS A N   1 ? 
ATOM   625  C CA  . LYS A 1 78  ? 19.983 3.876  -2.841  1.000 25.180 0  78   LYS A CA  1 ? 
ATOM   626  C C   . LYS A 1 78  ? 18.541 3.703  -3.296  1.000 21.010 0  78   LYS A C   1 ? 
ATOM   627  O O   . LYS A 1 78  ? 18.159 2.755  -3.974  1.000 21.920 0  78   LYS A O   1 ? 
ATOM   628  C CB  . LYS A 1 78  ? 21.015 2.946  -3.487  1.000 29.360 0  78   LYS A CB  1 ? 
ATOM   629  C CG  . LYS A 1 78  ? 21.529 3.448  -4.797  1.000 37.070 0  78   LYS A CG  1 ? 
ATOM   630  C CD  . LYS A 1 78  ? 22.755 2.713  -5.324  1.000 39.830 0  78   LYS A CD  1 ? 
ATOM   631  C CE  . LYS A 1 78  ? 22.992 3.222  -6.712  1.000 40.410 0  78   LYS A CE  1 ? 
ATOM   632  N NZ  . LYS A 1 78  ? 24.353 2.925  -7.150  1.000 45.460 0  78   LYS A NZ  1 ? 
ATOM   633  N N   . VAL A 1 79  ? 17.721 4.653  -2.871  1.000 19.960 0  79   VAL A N   1 ? 
ATOM   634  C CA  . VAL A 1 79  ? 16.313 4.740  -3.168  1.000 18.330 0  79   VAL A CA  1 ? 
ATOM   635  C C   . VAL A 1 79  ? 16.124 6.107  -3.807  1.000 21.810 0  79   VAL A C   1 ? 
ATOM   636  O O   . VAL A 1 79  ? 16.474 7.129  -3.211  1.000 21.310 0  79   VAL A O   1 ? 
ATOM   637  C CB  . VAL A 1 79  ? 15.453 4.601  -1.905  1.000 19.160 0  79   VAL A CB  1 ? 
ATOM   638  C CG1 . VAL A 1 79  ? 14.002 4.968  -2.154  1.000 19.240 0  79   VAL A CG1 1 ? 
ATOM   639  C CG2 . VAL A 1 79  ? 15.553 3.200  -1.343  1.000 21.250 0  79   VAL A CG2 1 ? 
ATOM   640  N N   . ILE A 1 80  ? 15.524 6.121  -4.987  1.000 18.010 0  80   ILE A N   1 ? 
ATOM   641  C CA  . ILE A 1 80  ? 15.406 7.337  -5.753  1.000 19.520 0  80   ILE A CA  1 ? 
ATOM   642  C C   . ILE A 1 80  ? 13.948 7.710  -5.914  1.000 20.220 0  80   ILE A C   1 ? 
ATOM   643  O O   . ILE A 1 80  ? 13.096 6.877  -6.223  1.000 18.610 0  80   ILE A O   1 ? 
ATOM   644  C CB  . ILE A 1 80  ? 16.151 7.178  -7.088  1.000 21.060 0  80   ILE A CB  1 ? 
ATOM   645  C CG1 . ILE A 1 80  ? 16.351 8.515  -7.759  1.000 22.200 0  80   ILE A CG1 1 ? 
ATOM   646  C CG2 . ILE A 1 80  ? 15.479 6.194  -8.047  1.000 21.000 0  80   ILE A CG2 1 ? 
ATOM   647  C CD1 . ILE A 1 80  ? 17.302 8.438  -8.949  1.000 23.840 0  80   ILE A CD1 1 ? 
ATOM   648  N N   . ALA A 1 81  ? 13.681 9.010  -5.742  1.000 17.520 0  81   ALA A N   1 ? 
ATOM   649  C CA  . ALA A 1 81  ? 12.397 9.584  -6.047  1.000 17.160 0  81   ALA A CA  1 ? 
ATOM   650  C C   . ALA A 1 81  ? 12.470 10.311 -7.382  1.000 17.670 0  81   ALA A C   1 ? 
ATOM   651  O O   . ALA A 1 81  ? 13.360 11.128 -7.638  1.000 15.910 0  81   ALA A O   1 ? 
ATOM   652  C CB  . ALA A 1 81  ? 11.989 10.506 -4.933  1.000 18.090 0  81   ALA A CB  1 ? 
ATOM   653  N N   . LEU A 1 82  ? 11.535 9.941  -8.258  1.000 18.240 0  82   LEU A N   1 ? 
ATOM   654  C CA  . LEU A 1 82  ? 11.418 10.530 -9.578  1.000 18.340 0  82   LEU A CA  1 ? 
ATOM   655  C C   . LEU A 1 82  ? 10.043 11.113 -9.792  1.000 17.980 0  82   LEU A C   1 ? 
ATOM   656  O O   . LEU A 1 82  ? 9.024  10.577 -9.346  1.000 18.710 0  82   LEU A O   1 ? 
ATOM   657  C CB  . LEU A 1 82  ? 11.675 9.436  -10.608 1.000 20.510 0  82   LEU A CB  1 ? 
ATOM   658  C CG  . LEU A 1 82  ? 13.038 8.766  -10.485 1.000 22.570 0  82   LEU A CG  1 ? 
ATOM   659  C CD1 . LEU A 1 82  ? 12.920 7.409  -11.082 1.000 27.450 0  82   LEU A CD1 1 ? 
ATOM   660  C CD2 . LEU A 1 82  ? 14.067 9.615  -11.190 1.000 25.780 0  82   LEU A CD2 1 ? 
ATOM   661  N N   . LYS A 1 83  ? 9.998  12.204 -10.546 1.000 18.800 0  83   LYS A N   1 ? 
ATOM   662  C CA  . LYS A 1 83  ? 8.688  12.730 -10.864 1.000 18.820 0  83   LYS A CA  1 ? 
ATOM   663  C C   . LYS A 1 83  ? 8.644  13.270 -12.282 1.000 18.830 0  83   LYS A C   1 ? 
ATOM   664  O O   . LYS A 1 83  ? 9.651  13.688 -12.850 1.000 21.170 0  83   LYS A O   1 ? 
ATOM   665  C CB  . LYS A 1 83  ? 8.207  13.808 -9.890  1.000 20.480 0  83   LYS A CB  1 ? 
ATOM   666  C CG  . LYS A 1 83  ? 9.000  15.094 -9.972  1.000 21.050 0  83   LYS A CG  1 ? 
ATOM   667  C CD  . LYS A 1 83  ? 8.476  16.174 -9.024  1.000 20.770 0  83   LYS A CD  1 ? 
ATOM   668  C CE  . LYS A 1 83  ? 9.357  17.358 -8.920  1.000 21.960 0  83   LYS A CE  1 ? 
ATOM   669  N NZ  . LYS A 1 83  ? 9.235  18.210 -10.098 1.000 25.020 0  83   LYS A NZ  1 ? 
ATOM   670  N N   . ALA A 1 84  ? 7.415  13.305 -12.795 1.000 20.760 0  84   ALA A N   1 ? 
ATOM   671  C CA  . ALA A 1 84  ? 7.088  13.870 -14.090 1.000 24.790 0  84   ALA A CA  1 ? 
ATOM   672  C C   . ALA A 1 84  ? 5.725  14.540 -13.973 1.000 25.780 0  84   ALA A C   1 ? 
ATOM   673  O O   . ALA A 1 84  ? 4.685  13.867 -13.928 1.000 27.510 0  84   ALA A O   1 ? 
ATOM   674  C CB  . ALA A 1 84  ? 7.117  12.790 -15.169 1.000 28.770 0  84   ALA A CB  1 ? 
ATOM   675  N N   . GLY A 1 85  ? 5.783  15.859 -13.790 1.000 28.620 0  85   GLY A N   1 ? 
ATOM   676  C CA  . GLY A 1 85  ? 4.642  16.705 -13.479 1.000 29.610 0  85   GLY A CA  1 ? 
ATOM   677  C C   . GLY A 1 85  ? 3.968  16.298 -12.174 1.000 31.700 0  85   GLY A C   1 ? 
ATOM   678  O O   . GLY A 1 85  ? 4.438  16.662 -11.087 1.000 29.400 0  85   GLY A O   1 ? 
ATOM   679  N N   . LYS A 1 86  ? 2.839  15.578 -12.318 1.000 25.320 0  86   LYS A N   1 ? 
ATOM   680  C CA  . LYS A 1 86  ? 2.041  15.134 -11.190 1.000 26.800 0  86   LYS A CA  1 ? 
ATOM   681  C C   . LYS A 1 86  ? 2.372  13.710 -10.755 1.000 24.260 0  86   LYS A C   1 ? 
ATOM   682  O O   . LYS A 1 86  ? 1.914  13.278 -9.702  1.000 25.440 0  86   LYS A O   1 ? 
ATOM   683  C CB  . LYS A 1 86  ? 0.562  15.185 -11.562 1.000 29.190 0  86   LYS A CB  1 ? 
ATOM   684  C CG  . LYS A 1 86  ? 0.077  16.581 -11.875 1.000 29.220 0  86   LYS A CG  1 ? 
ATOM   685  C CD  . LYS A 1 86  ? -1.357 16.537 -12.384 1.000 35.550 0  86   LYS A CD  1 ? 
ATOM   686  C CE  . LYS A 1 86  ? -1.924 17.877 -12.720 1.000 39.790 0  86   LYS A CE  1 ? 
ATOM   687  N NZ  . LYS A 1 86  ? -1.165 18.517 -13.785 1.000 44.380 0  86   LYS A NZ  1 ? 
ATOM   688  N N   . THR A 1 87  ? 3.128  12.988 -11.588 1.000 24.160 0  87   THR A N   1 ? 
ATOM   689  C CA  . THR A 1 87  ? 3.398  11.580 -11.395 1.000 25.160 0  87   THR A CA  1 ? 
ATOM   690  C C   . THR A 1 87  ? 4.661  11.425 -10.547 1.000 24.280 0  87   THR A C   1 ? 
ATOM   691  O O   . THR A 1 87  ? 5.727  11.838 -10.994 1.000 22.150 0  87   THR A O   1 ? 
ATOM   692  C CB  . THR A 1 87  ? 3.595  10.928 -12.767 1.000 29.190 0  87   THR A CB  1 ? 
ATOM   693  O OG1 . THR A 1 87  ? 2.407  11.106 -13.523 1.000 28.790 0  87   THR A OG1 1 ? 
ATOM   694  C CG2 . THR A 1 87  ? 3.836  9.430  -12.692 1.000 29.830 0  87   THR A CG2 1 ? 
ATOM   695  N N   . LEU A 1 88  ? 4.525  10.764 -9.384  1.000 22.330 0  88   LEU A N   1 ? 
ATOM   696  C CA  . LEU A 1 88  ? 5.624  10.512 -8.444  1.000 22.720 0  88   LEU A CA  1 ? 
ATOM   697  C C   . LEU A 1 88  ? 5.839  9.016  -8.345  1.000 23.240 0  88   LEU A C   1 ? 
ATOM   698  O O   . LEU A 1 88  ? 4.868  8.264  -8.227  1.000 24.210 0  88   LEU A O   1 ? 
ATOM   699  C CB  . LEU A 1 88  ? 5.290  11.038 -7.046  1.000 21.540 0  88   LEU A CB  1 ? 
ATOM   700  C CG  . LEU A 1 88  ? 4.603  12.403 -7.002  1.000 23.040 0  88   LEU A CG  1 ? 
ATOM   701  C CD1 . LEU A 1 88  ? 4.324  12.772 -5.561  1.000 22.870 0  88   LEU A CD1 1 ? 
ATOM   702  C CD2 . LEU A 1 88  ? 5.444  13.464 -7.703  1.000 21.460 0  88   LEU A CD2 1 ? 
ATOM   703  N N   . GLN A 1 89  ? 7.097  8.610  -8.406  1.000 21.540 0  89   GLN A N   1 ? 
ATOM   704  C CA  . GLN A 1 89  ? 7.476  7.218  -8.248  1.000 21.710 0  89   GLN A CA  1 ? 
ATOM   705  C C   . GLN A 1 89  ? 8.758  7.108  -7.437  1.000 22.620 0  89   GLN A C   1 ? 
ATOM   706  O O   . GLN A 1 89  ? 9.678  7.928  -7.597  1.000 21.610 0  89   GLN A O   1 ? 
ATOM   707  C CB  . GLN A 1 89  ? 7.735  6.572  -9.601  1.000 21.650 0  89   GLN A CB  1 ? 
ATOM   708  C CG  . GLN A 1 89  ? 6.483  6.476  -10.453 1.000 21.970 0  89   GLN A CG  1 ? 
ATOM   709  C CD  . GLN A 1 89  ? 6.750  5.843  -11.800 1.000 22.640 0  89   GLN A CD  1 ? 
ATOM   710  O OE1 . GLN A 1 89  ? 7.875  5.526  -12.182 1.000 25.560 0  89   GLN A OE1 1 ? 
ATOM   711  N NE2 . GLN A 1 89  ? 5.686  5.654  -12.549 1.000 27.350 0  89   GLN A NE2 1 ? 
ATOM   712  N N   . ILE A 1 90  ? 8.803  6.092  -6.581  1.000 19.710 0  90   ILE A N   1 ? 
ATOM   713  C CA  . ILE A 1 90  ? 9.943  5.809  -5.722  1.000 19.730 0  90   ILE A CA  1 ? 
ATOM   714  C C   . ILE A 1 90  ? 10.501 4.434  -6.083  1.000 20.830 0  90   ILE A C   1 ? 
ATOM   715  O O   . ILE A 1 90  ? 9.755  3.458  -6.035  1.000 22.440 0  90   ILE A O   1 ? 
ATOM   716  C CB  . ILE A 1 90  ? 9.517  5.794  -4.246  1.000 20.030 0  90   ILE A CB  1 ? 
ATOM   717  C CG1 . ILE A 1 90  ? 8.663  7.025  -3.835  1.000 23.300 0  90   ILE A CG1 1 ? 
ATOM   718  C CG2 . ILE A 1 90  ? 10.730 5.587  -3.349  1.000 21.480 0  90   ILE A CG2 1 ? 
ATOM   719  C CD1 . ILE A 1 90  ? 9.428  8.327  -3.785  1.000 23.320 0  90   ILE A CD1 1 ? 
ATOM   720  N N   . PHE A 1 91  ? 11.789 4.330  -6.380  1.000 18.170 0  91   PHE A N   1 ? 
ATOM   721  C CA  . PHE A 1 91  ? 12.377 3.040  -6.729  1.000 20.000 0  91   PHE A CA  1 ? 
ATOM   722  C C   . PHE A 1 91  ? 13.492 2.687  -5.767  1.000 22.090 0  91   PHE A C   1 ? 
ATOM   723  O O   . PHE A 1 91  ? 14.322 3.539  -5.419  1.000 19.690 0  91   PHE A O   1 ? 
ATOM   724  C CB  . PHE A 1 91  ? 12.982 3.019  -8.130  1.000 20.070 0  91   PHE A CB  1 ? 
ATOM   725  C CG  . PHE A 1 91  ? 11.945 3.116  -9.221  1.000 21.440 0  91   PHE A CG  1 ? 
ATOM   726  C CD1 . PHE A 1 91  ? 11.331 4.318  -9.511  1.000 21.260 0  91   PHE A CD1 1 ? 
ATOM   727  C CD2 . PHE A 1 91  ? 11.576 1.972  -9.937  1.000 24.870 0  91   PHE A CD2 1 ? 
ATOM   728  C CE1 . PHE A 1 91  ? 10.414 4.401  -10.527 1.000 24.140 0  91   PHE A CE1 1 ? 
ATOM   729  C CE2 . PHE A 1 91  ? 10.629 2.055  -10.937 1.000 25.020 0  91   PHE A CE2 1 ? 
ATOM   730  C CZ  . PHE A 1 91  ? 10.046 3.255  -11.220 1.000 22.590 0  91   PHE A CZ  1 ? 
ATOM   731  N N   . ASN A 1 92  ? 13.542 1.399  -5.403  1.000 20.510 0  92   ASN A N   1 ? 
ATOM   732  C CA  . ASN A 1 92  ? 14.723 0.832  -4.777  1.000 20.700 0  92   ASN A CA  1 ? 
ATOM   733  C C   . ASN A 1 92  ? 15.624 0.332  -5.901  1.000 21.830 0  92   ASN A C   1 ? 
ATOM   734  O O   . ASN A 1 92  ? 15.232 -0.572 -6.643  1.000 22.960 0  92   ASN A O   1 ? 
ATOM   735  C CB  . ASN A 1 92  ? 14.402 -0.305 -3.816  1.000 20.300 0  92   ASN A CB  1 ? 
ATOM   736  C CG  . ASN A 1 92  ? 15.639 -0.830 -3.130  1.000 21.630 0  92   ASN A CG  1 ? 
ATOM   737  O OD1 . ASN A 1 92  ? 16.631 -1.177 -3.774  1.000 22.230 0  92   ASN A OD1 1 ? 
ATOM   738  N ND2 . ASN A 1 92  ? 15.633 -0.843 -1.805  1.000 21.760 0  92   ASN A ND2 1 ? 
ATOM   739  N N   . ILE A 1 93  ? 16.769 0.983  -6.076  1.000 20.570 0  93   ILE A N   1 ? 
ATOM   740  C CA  . ILE A 1 93  ? 17.585 0.751  -7.254  1.000 20.370 0  93   ILE A CA  1 ? 
ATOM   741  C C   . ILE A 1 93  ? 18.150 -0.673 -7.288  1.000 22.630 0  93   ILE A C   1 ? 
ATOM   742  O O   . ILE A 1 93  ? 18.103 -1.347 -8.325  1.000 22.580 0  93   ILE A O   1 ? 
ATOM   743  C CB  . ILE A 1 93  ? 18.683 1.821  -7.322  1.000 23.310 0  93   ILE A CB  1 ? 
ATOM   744  C CG1 . ILE A 1 93  ? 18.070 3.175  -7.608  1.000 24.240 0  93   ILE A CG1 1 ? 
ATOM   745  C CG2 . ILE A 1 93  ? 19.768 1.450  -8.344  1.000 25.540 0  93   ILE A CG2 1 ? 
ATOM   746  C CD1 . ILE A 1 93  ? 19.032 4.322  -7.412  1.000 28.140 0  93   ILE A CD1 1 ? 
ATOM   747  N N   . GLU A 1 94  ? 18.675 -1.137 -6.169  1.000 21.280 0  94   GLU A N   1 ? 
ATOM   748  C CA  . GLU A 1 94  ? 19.361 -2.420 -6.131  1.000 24.050 0  94   GLU A CA  1 ? 
ATOM   749  C C   . GLU A 1 94  ? 18.316 -3.534 -6.287  1.000 24.070 0  94   GLU A C   1 ? 
ATOM   750  O O   . GLU A 1 94  ? 18.599 -4.579 -6.859  1.000 23.750 0  94   GLU A O   1 ? 
ATOM   751  C CB  . GLU A 1 94  ? 20.104 -2.515 -4.801  1.000 28.770 0  94   GLU A CB  1 ? 
ATOM   752  C CG  . GLU A 1 94  ? 21.238 -1.506 -4.577  1.000 34.400 0  94   GLU A CG  1 ? 
ATOM   753  C CD  . GLU A 1 94  ? 21.633 -1.264 -3.106  1.000 44.640 0  94   GLU A CD  1 ? 
ATOM   754  O OE1 . GLU A 1 94  ? 20.772 -1.195 -2.147  1.000 39.220 0  94   GLU A OE1 1 ? 
ATOM   755  O OE2 . GLU A 1 94  ? 22.863 -1.065 -2.919  1.000 53.430 0  94   GLU A OE2 1 ? 
ATOM   756  N N   . MET A 1 95  ? 17.083 -3.301 -5.825  1.000 20.670 0  95   MET A N   1 ? 
ATOM   757  C CA  . MET A 1 95  ? 16.011 -4.281 -5.977  1.000 19.710 0  95   MET A CA  1 ? 
ATOM   758  C C   . MET A 1 95  ? 15.340 -4.194 -7.341  1.000 21.450 0  95   MET A C   1 ? 
ATOM   759  O O   . MET A 1 95  ? 14.499 -5.029 -7.652  1.000 23.800 0  95   MET A O   1 ? 
ATOM   760  C CB  . MET A 1 95  ? 14.940 -4.106 -4.910  1.000 19.670 0  95   MET A CB  1 ? 
ATOM   761  C CG  . MET A 1 95  ? 15.469 -4.482 -3.554  1.000 20.550 0  95   MET A CG  1 ? 
ATOM   762  S SD  . MET A 1 95  ? 14.291 -4.241 -2.206  1.000 25.220 0  95   MET A SD  1 ? 
ATOM   763  C CE  . MET A 1 95  ? 12.956 -5.350 -2.617  1.000 23.450 0  95   MET A CE  1 ? 
ATOM   764  N N   . LYS A 1 96  ? 15.715 -3.174 -8.126  1.000 23.480 0  96   LYS A N   1 ? 
ATOM   765  C CA  . LYS A 1 96  ? 15.067 -2.839 -9.382  1.000 27.310 0  96   LYS A CA  1 ? 
ATOM   766  C C   . LYS A 1 96  ? 13.559 -2.817 -9.231  1.000 26.970 0  96   LYS A C   1 ? 
ATOM   767  O O   . LYS A 1 96  ? 12.835 -3.344 -10.073 1.000 31.540 0  96   LYS A O   1 ? 
ATOM   768  C CB  . LYS A 1 96  ? 15.474 -3.859 -10.451 1.000 26.340 0  96   LYS A CB  1 ? 
ATOM   769  C CG  . LYS A 1 96  ? 16.956 -4.034 -10.558 1.000 28.130 0  96   LYS A CG  1 ? 
ATOM   770  C CD  . LYS A 1 96  ? 17.400 -4.817 -11.790 1.000 35.650 0  96   LYS A CD  1 ? 
ATOM   771  C CE  . LYS A 1 96  ? 18.872 -5.080 -11.702 1.000 42.500 0  96   LYS A CE  1 ? 
ATOM   772  N NZ  . LYS A 1 96  ? 19.335 -5.883 -12.836 1.000 49.140 0  96   LYS A NZ  1 ? 
ATOM   773  N N   . SER A 1 97  ? 13.064 -2.155 -8.188  1.000 27.660 0  97   SER A N   1 ? 
ATOM   774  C CA  . SER A 1 97  ? 11.691 -2.328 -7.772  1.000 29.600 0  97   SER A CA  1 ? 
ATOM   775  C C   . SER A 1 97  ? 11.042 -0.978 -7.474  1.000 28.200 0  97   SER A C   1 ? 
ATOM   776  O O   . SER A 1 97  ? 11.626 -0.137 -6.796  1.000 25.260 0  97   SER A O   1 ? 
ATOM   777  C CB  . SER A 1 97  ? 11.674 -3.253 -6.588  1.000 33.310 0  97   SER A CB  1 ? 
ATOM   778  O OG  . SER A 1 97  ? 10.392 -3.355 -6.000  1.000 42.580 0  97   SER A OG  1 ? 
ATOM   779  N N   . LYS A 1 98  ? 9.844  -0.775 -8.008  1.000 26.200 0  98   LYS A N   1 ? 
ATOM   780  C CA  . LYS A 1 98  ? 9.043  0.392  -7.689  1.000 25.210 0  98   LYS A CA  1 ? 
ATOM   781  C C   . LYS A 1 98  ? 8.346  0.211  -6.348  1.000 26.840 0  98   LYS A C   1 ? 
ATOM   782  O O   . LYS A 1 98  ? 7.371  -0.525 -6.237  1.000 29.420 0  98   LYS A O   1 ? 
ATOM   783  C CB  . LYS A 1 98  ? 8.062  0.679  -8.823  1.000 27.200 0  98   LYS A CB  1 ? 
ATOM   784  C CG  . LYS A 1 98  ? 7.176  1.902  -8.593  1.000 28.800 0  98   LYS A CG  1 ? 
ATOM   785  C CD  . LYS A 1 98  ? 6.445  2.377  -9.844  1.000 36.350 0  98   LYS A CD  1 ? 
ATOM   786  C CE  . LYS A 1 98  ? 5.497  1.365  -10.422 1.000 44.540 0  98   LYS A CE  1 ? 
ATOM   787  N NZ  . LYS A 1 98  ? 5.269  1.629  -11.853 1.000 46.700 0  98   LYS A NZ  1 ? 
ATOM   788  N N   A MET A 1 99  ? 8.832  0.942  -5.347  0.700 23.360 0  99   MET A N   1 ? 
ATOM   789  N N   B MET A 1 99  ? 8.801  0.951  -5.334  0.300 25.920 0  99   MET A N   1 ? 
ATOM   790  C CA  A MET A 1 99  ? 8.344  0.829  -3.986  0.700 26.800 0  99   MET A CA  1 ? 
ATOM   791  C CA  B MET A 1 99  ? 8.335  0.730  -3.976  0.300 27.930 0  99   MET A CA  1 ? 
ATOM   792  C C   A MET A 1 99  ? 6.940  1.417  -3.893  0.700 26.330 0  99   MET A C   1 ? 
ATOM   793  C C   B MET A 1 99  ? 7.056  1.528  -3.695  0.300 26.780 0  99   MET A C   1 ? 
ATOM   794  O O   A MET A 1 99  ? 6.027  0.844  -3.313  0.700 24.860 0  99   MET A O   1 ? 
ATOM   795  O O   B MET A 1 99  ? 6.328  1.175  -2.765  0.300 25.040 0  99   MET A O   1 ? 
ATOM   796  C CB  A MET A 1 99  ? 9.226  1.629  -3.025  0.700 29.240 0  99   MET A CB  1 ? 
ATOM   797  C CB  B MET A 1 99  ? 9.416  1.079  -2.945  0.300 29.960 0  99   MET A CB  1 ? 
ATOM   798  C CG  A MET A 1 99  ? 10.536 0.974  -2.688  0.700 30.070 0  99   MET A CG  1 ? 
ATOM   799  C CG  B MET A 1 99  ? 10.711 0.282  -3.052  0.300 33.090 0  99   MET A CG  1 ? 
ATOM   800  S SD  A MET A 1 99  ? 11.762 2.145  -2.052  0.700 30.170 0  99   MET A SD  1 ? 
ATOM   801  S SD  B MET A 1 99  ? 10.698 -1.392 -2.371  0.300 38.050 0  99   MET A SD  1 ? 
ATOM   802  C CE  A MET A 1 99  ? 10.980 2.755  -0.553  0.700 29.760 0  99   MET A CE  1 ? 
ATOM   803  C CE  B MET A 1 99  ? 9.977  -2.188 -3.803  0.300 34.630 0  99   MET A CE  1 ? 
ATOM   804  N N   . LYS A 1 100 ? 6.799  2.608  -4.459  1.000 25.500 0  100  LYS A N   1 ? 
ATOM   805  C CA  . LYS A 1 100 ? 5.632  3.448  -4.222  1.000 25.430 0  100  LYS A CA  1 ? 
ATOM   806  C C   . LYS A 1 100 ? 5.396  4.323  -5.445  1.000 25.660 0  100  LYS A C   1 ? 
ATOM   807  O O   . LYS A 1 100 ? 6.333  4.624  -6.195  1.000 25.020 0  100  LYS A O   1 ? 
ATOM   808  C CB  . LYS A 1 100 ? 5.861  4.431  -3.073  1.000 30.510 0  100  LYS A CB  1 ? 
ATOM   809  C CG  . LYS A 1 100 ? 5.798  3.875  -1.688  1.000 34.990 0  100  LYS A CG  1 ? 
ATOM   810  C CD  . LYS A 1 100 ? 5.278  4.916  -0.704  1.000 36.140 0  100  LYS A CD  1 ? 
ATOM   811  C CE  . LYS A 1 100 ? 4.757  4.223  0.489   1.000 35.230 0  100  LYS A CE  1 ? 
ATOM   812  N NZ  . LYS A 1 100 ? 4.216  5.188  1.429   1.000 33.880 0  100  LYS A NZ  1 ? 
ATOM   813  N N   . ALA A 1 101 ? 4.132  4.684  -5.658  1.000 24.830 0  101  ALA A N   1 ? 
ATOM   814  C CA  . ALA A 1 101 ? 3.744  5.616  -6.702  1.000 26.530 0  101  ALA A CA  1 ? 
ATOM   815  C C   . ALA A 1 101 ? 2.533  6.413  -6.244  1.000 27.170 0  101  ALA A C   1 ? 
ATOM   816  O O   . ALA A 1 101 ? 1.716  5.935  -5.462  1.000 28.270 0  101  ALA A O   1 ? 
ATOM   817  C CB  . ALA A 1 101 ? 3.459  4.923  -8.019  1.000 28.800 0  101  ALA A CB  1 ? 
ATOM   818  N N   . HIS A 1 102 ? 2.442  7.655  -6.737  1.000 25.920 0  102  HIS A N   1 ? 
ATOM   819  C CA  . HIS A 1 102 ? 1.307  8.497  -6.434  1.000 24.710 0  102  HIS A CA  1 ? 
ATOM   820  C C   . HIS A 1 102 ? 1.143  9.497  -7.560  1.000 27.660 0  102  HIS A C   1 ? 
ATOM   821  O O   . HIS A 1 102 ? 2.143  10.002 -8.068  1.000 27.930 0  102  HIS A O   1 ? 
ATOM   822  C CB  . HIS A 1 102 ? 1.485  9.203  -5.082  1.000 24.050 0  102  HIS A CB  1 ? 
ATOM   823  C CG  . HIS A 1 102 ? 0.251  9.891  -4.641  1.000 24.520 0  102  HIS A CG  1 ? 
ATOM   824  N ND1 . HIS A 1 102 ? -0.799 9.227  -4.026  1.000 25.590 0  102  HIS A ND1 1 ? 
ATOM   825  C CD2 . HIS A 1 102 ? -0.129 11.153 -4.774  1.000 26.050 0  102  HIS A CD2 1 ? 
ATOM   826  C CE1 . HIS A 1 102 ? -1.755 10.103 -3.751  1.000 27.230 0  102  HIS A CE1 1 ? 
ATOM   827  N NE2 . HIS A 1 102 ? -1.370 11.276 -4.209  1.000 28.870 0  102  HIS A NE2 1 ? 
ATOM   828  N N   . THR A 1 103 ? -0.116 9.845  -7.880  1.000 24.900 0  103  THR A N   1 ? 
ATOM   829  C CA  . THR A 1 103 ? -0.349 10.925 -8.818  1.000 25.830 0  103  THR A CA  1 ? 
ATOM   830  C C   . THR A 1 103 ? -0.989 12.082 -8.064  1.000 25.230 0  103  THR A C   1 ? 
ATOM   831  O O   . THR A 1 103 ? -2.046 11.921 -7.466  1.000 24.810 0  103  THR A O   1 ? 
ATOM   832  C CB  . THR A 1 103 ? -1.221 10.423 -9.973  1.000 31.500 0  103  THR A CB  1 ? 
ATOM   833  O OG1 . THR A 1 103 ? -0.441 9.441  -10.650 1.000 31.180 0  103  THR A OG1 1 ? 
ATOM   834  C CG2 . THR A 1 103 ? -1.546 11.524 -10.964 1.000 34.040 0  103  THR A CG2 1 ? 
ATOM   835  N N   . MET A 1 104 ? -0.348 13.253 -8.071  1.000 26.160 0  104  MET A N   1 ? 
ATOM   836  C CA  . MET A 1 104 ? -0.891 14.428 -7.396  1.000 24.940 0  104  MET A CA  1 ? 
ATOM   837  C C   . MET A 1 104 ? -1.956 15.097 -8.271  1.000 25.260 0  104  MET A C   1 ? 
ATOM   838  O O   . MET A 1 104 ? -1.990 14.846 -9.480  1.000 26.790 0  104  MET A O   1 ? 
ATOM   839  C CB  . MET A 1 104 ? 0.213  15.461 -7.125  1.000 23.500 0  104  MET A CB  1 ? 
ATOM   840  C CG  . MET A 1 104 ? 1.351  14.964 -6.206  1.000 22.970 0  104  MET A CG  1 ? 
ATOM   841  S SD  . MET A 1 104 ? 0.822  14.708 -4.510  1.000 27.220 0  104  MET A SD  1 ? 
ATOM   842  C CE  . MET A 1 104 ? 0.647  16.404 -3.926  1.000 29.660 0  104  MET A CE  1 ? 
ATOM   843  N N   . THR A 1 105 ? -2.791 15.931 -7.630  1.000 25.580 0  105  THR A N   1 ? 
ATOM   844  C CA  . THR A 1 105 ? -3.748 16.813 -8.288  1.000 30.920 0  105  THR A CA  1 ? 
ATOM   845  C C   . THR A 1 105 ? -3.016 17.895 -9.075  1.000 33.400 0  105  THR A C   1 ? 
ATOM   846  O O   . THR A 1 105 ? -3.404 18.232 -10.186 1.000 29.780 0  105  THR A O   1 ? 
ATOM   847  C CB  . THR A 1 105 ? -4.644 17.463 -7.233  1.000 34.940 0  105  THR A CB  1 ? 
ATOM   848  O OG1 . THR A 1 105 ? -5.396 16.401 -6.662  1.000 39.680 0  105  THR A OG1 1 ? 
ATOM   849  C CG2 . THR A 1 105 ? -5.572 18.507 -7.828  1.000 39.900 0  105  THR A CG2 1 ? 
ATOM   850  N N   . ASP A 1 106 ? -1.947 18.441 -8.468  1.000 23.690 0  106  ASP A N   1 ? 
ATOM   851  C CA  . ASP A 1 106 ? -1.232 19.585 -9.003  1.000 25.120 0  106  ASP A CA  1 ? 
ATOM   852  C C   . ASP A 1 106 ? 0.227  19.177 -9.192  1.000 24.150 0  106  ASP A C   1 ? 
ATOM   853  O O   . ASP A 1 106 ? 0.724  18.288 -8.484  1.000 24.380 0  106  ASP A O   1 ? 
ATOM   854  C CB  . ASP A 1 106 ? -1.310 20.796 -8.083  1.000 27.240 0  106  ASP A CB  1 ? 
ATOM   855  C CG  . ASP A 1 106 ? -2.693 21.313 -7.704  1.000 32.880 0  106  ASP A CG  1 ? 
ATOM   856  O OD1 . ASP A 1 106 ? -3.569 21.347 -8.600  1.000 34.160 0  106  ASP A OD1 1 ? 
ATOM   857  O OD2 . ASP A 1 106 ? -2.880 21.723 -6.527  1.000 31.680 0  106  ASP A OD2 1 ? 
ATOM   858  N N   . ASP A 1 107 ? 0.882  19.798 -10.169 1.000 23.640 0  107  ASP A N   1 ? 
ATOM   859  C CA  . ASP A 1 107 ? 2.296  19.596 -10.434 1.000 23.500 0  107  ASP A CA  1 ? 
ATOM   860  C C   . ASP A 1 107 ? 3.100  19.852 -9.156  1.000 22.360 0  107  ASP A C   1 ? 
ATOM   861  O O   . ASP A 1 107 ? 2.844  20.800 -8.417  1.000 21.980 0  107  ASP A O   1 ? 
ATOM   862  C CB  . ASP A 1 107 ? 2.813  20.533 -11.510 1.000 29.160 0  107  ASP A CB  1 ? 
ATOM   863  C CG  . ASP A 1 107 ? 2.437  20.188 -12.949 1.000 34.790 0  107  ASP A CG  1 ? 
ATOM   864  O OD1 . ASP A 1 107 ? 1.903  19.094 -13.182 1.000 36.700 0  107  ASP A OD1 1 ? 
ATOM   865  O OD2 . ASP A 1 107 ? 2.705  21.021 -13.825 1.000 39.790 0  107  ASP A OD2 1 ? 
ATOM   866  N N   . VAL A 1 108 ? 4.056  18.968 -8.894  1.000 23.130 0  108  VAL A N   1 ? 
ATOM   867  C CA  . VAL A 1 108 ? 5.041  19.225 -7.854  1.000 21.490 0  108  VAL A CA  1 ? 
ATOM   868  C C   . VAL A 1 108 ? 6.171  20.066 -8.439  1.000 21.540 0  108  VAL A C   1 ? 
ATOM   869  O O   . VAL A 1 108 ? 6.919  19.584 -9.277  1.000 26.070 0  108  VAL A O   1 ? 
ATOM   870  C CB  . VAL A 1 108 ? 5.503  17.902 -7.222  1.000 20.600 0  108  VAL A CB  1 ? 
ATOM   871  C CG1 . VAL A 1 108 ? 6.668  18.089 -6.258  1.000 20.530 0  108  VAL A CG1 1 ? 
ATOM   872  C CG2 . VAL A 1 108 ? 4.351  17.173 -6.548  1.000 22.390 0  108  VAL A CG2 1 ? 
ATOM   873  N N   . THR A 1 109 ? 6.324  21.323 -7.976  1.000 20.350 0  109  THR A N   1 ? 
ATOM   874  C CA  . THR A 1 109 ? 7.300  22.238 -8.548  1.000 21.100 0  109  THR A CA  1 ? 
ATOM   875  C C   . THR A 1 109 ? 8.633  22.188 -7.802  1.000 20.030 0  109  THR A C   1 ? 
ATOM   876  O O   . THR A 1 109 ? 9.664  22.566 -8.355  1.000 22.110 0  109  THR A O   1 ? 
ATOM   877  C CB  . THR A 1 109 ? 6.732  23.644 -8.553  1.000 27.790 0  109  THR A CB  1 ? 
ATOM   878  O OG1 . THR A 1 109 ? 6.446  23.954 -7.190  1.000 25.370 0  109  THR A OG1 1 ? 
ATOM   879  C CG2 . THR A 1 109 ? 5.460  23.718 -9.385  1.000 28.220 0  109  THR A CG2 1 ? 
ATOM   880  N N   . PHE A 1 110 ? 8.623  21.657 -6.570  1.000 17.430 0  110  PHE A N   1 ? 
ATOM   881  C CA  . PHE A 1 110 ? 9.840  21.497 -5.797  1.000 16.010 0  110  PHE A CA  1 ? 
ATOM   882  C C   . PHE A 1 110 ? 9.615  20.323 -4.856  1.000 16.840 0  110  PHE A C   1 ? 
ATOM   883  O O   . PHE A 1 110 ? 8.508  20.193 -4.354  1.000 17.200 0  110  PHE A O   1 ? 
ATOM   884  C CB  . PHE A 1 110 ? 10.123 22.784 -4.996  1.000 15.940 0  110  PHE A CB  1 ? 
ATOM   885  C CG  . PHE A 1 110 ? 11.338 22.718 -4.101  1.000 16.020 0  110  PHE A CG  1 ? 
ATOM   886  C CD1 . PHE A 1 110 ? 12.611 23.060 -4.562  1.000 17.030 0  110  PHE A CD1 1 ? 
ATOM   887  C CD2 . PHE A 1 110 ? 11.232 22.262 -2.795  1.000 14.930 0  110  PHE A CD2 1 ? 
ATOM   888  C CE1 . PHE A 1 110 ? 13.713 22.985 -3.704  1.000 17.400 0  110  PHE A CE1 1 ? 
ATOM   889  C CE2 . PHE A 1 110 ? 12.354 22.103 -1.992  1.000 16.010 0  110  PHE A CE2 1 ? 
ATOM   890  C CZ  . PHE A 1 110 ? 13.574 22.522 -2.411  1.000 16.290 0  110  PHE A CZ  1 ? 
ATOM   891  N N   . TRP A 1 111 ? 10.652 19.521 -4.594  1.000 15.530 0  111  TRP A N   1 ? 
ATOM   892  C CA  . TRP A 1 111 ? 10.556 18.486 -3.593  1.000 14.560 0  111  TRP A CA  1 ? 
ATOM   893  C C   . TRP A 1 111 ? 11.935 18.188 -3.035  1.000 14.390 0  111  TRP A C   1 ? 
ATOM   894  O O   . TRP A 1 111 ? 12.936 18.538 -3.649  1.000 15.130 0  111  TRP A O   1 ? 
ATOM   895  C CB  . TRP A 1 111 ? 9.830  17.224 -4.108  1.000 15.720 0  111  TRP A CB  1 ? 
ATOM   896  C CG  . TRP A 1 111 ? 10.510 16.473 -5.203  1.000 16.050 0  111  TRP A CG  1 ? 
ATOM   897  C CD1 . TRP A 1 111 ? 11.539 16.822 -6.025  1.000 17.530 0  111  TRP A CD1 1 ? 
ATOM   898  C CD2 . TRP A 1 111 ? 10.113 15.141 -5.594  1.000 15.700 0  111  TRP A CD2 1 ? 
ATOM   899  N NE1 . TRP A 1 111 ? 11.816 15.786 -6.879  1.000 19.480 0  111  TRP A NE1 1 ? 
ATOM   900  C CE2 . TRP A 1 111 ? 10.952 14.761 -6.657  1.000 18.860 0  111  TRP A CE2 1 ? 
ATOM   901  C CE3 . TRP A 1 111 ? 9.133  14.263 -5.135  1.000 18.220 0  111  TRP A CE3 1 ? 
ATOM   902  C CZ2 . TRP A 1 111 ? 10.851 13.506 -7.255  1.000 17.220 0  111  TRP A CZ2 1 ? 
ATOM   903  C CZ3 . TRP A 1 111 ? 8.988  13.050 -5.767  1.000 19.590 0  111  TRP A CZ3 1 ? 
ATOM   904  C CH2 . TRP A 1 111 ? 9.859  12.679 -6.794  1.000 18.780 0  111  TRP A CH2 1 ? 
ATOM   905  N N   . LYS A 1 112 ? 11.965 17.629 -1.832  1.000 14.330 0  112  LYS A N   1 ? 
ATOM   906  C CA  . LYS A 1 112 ? 13.196 17.361 -1.118  1.000 15.680 0  112  LYS A CA  1 ? 
ATOM   907  C C   . LYS A 1 112 ? 12.931 16.306 -0.065  1.000 16.220 0  112  LYS A C   1 ? 
ATOM   908  O O   . LYS A 1 112 ? 11.900 16.362 0.602   1.000 16.640 0  112  LYS A O   1 ? 
ATOM   909  C CB  . LYS A 1 112 ? 13.649 18.634 -0.392  1.000 18.330 0  112  LYS A CB  1 ? 
ATOM   910  C CG  . LYS A 1 112 ? 15.017 18.570 0.233   1.000 23.720 0  112  LYS A CG  1 ? 
ATOM   911  C CD  . LYS A 1 112 ? 15.613 19.958 0.441   1.000 25.320 0  112  LYS A CD  1 ? 
ATOM   912  C CE  . LYS A 1 112 ? 17.043 19.905 0.873   1.000 32.320 0  112  LYS A CE  1 ? 
ATOM   913  N NZ  . LYS A 1 112 ? 17.926 19.257 -0.108  1.000 36.310 0  112  LYS A NZ  1 ? 
ATOM   914  N N   . TRP A 1 113 ? 13.912 15.428 0.158   1.000 14.370 0  113  TRP A N   1 ? 
ATOM   915  C CA  . TRP A 1 113 ? 13.831 14.561 1.315   1.000 15.830 0  113  TRP A CA  1 ? 
ATOM   916  C C   . TRP A 1 113 ? 14.066 15.396 2.570   1.000 18.240 0  113  TRP A C   1 ? 
ATOM   917  O O   . TRP A 1 113 ? 15.084 16.093 2.678   1.000 19.760 0  113  TRP A O   1 ? 
ATOM   918  C CB  . TRP A 1 113 ? 14.880 13.441 1.209   1.000 16.520 0  113  TRP A CB  1 ? 
ATOM   919  C CG  . TRP A 1 113 ? 14.601 12.443 0.122   1.000 15.440 0  113  TRP A CG  1 ? 
ATOM   920  C CD1 . TRP A 1 113 ? 15.043 12.449 -1.161  1.000 15.530 0  113  TRP A CD1 1 ? 
ATOM   921  C CD2 . TRP A 1 113 ? 13.806 11.240 0.272   1.000 15.820 0  113  TRP A CD2 1 ? 
ATOM   922  N NE1 . TRP A 1 113 ? 14.581 11.336 -1.834  1.000 16.780 0  113  TRP A NE1 1 ? 
ATOM   923  C CE2 . TRP A 1 113 ? 13.828 10.577 -0.968  1.000 15.570 0  113  TRP A CE2 1 ? 
ATOM   924  C CE3 . TRP A 1 113 ? 13.078 10.690 1.337   1.000 16.750 0  113  TRP A CE3 1 ? 
ATOM   925  C CZ2 . TRP A 1 113 ? 13.149 9.368  -1.162  1.000 18.090 0  113  TRP A CZ2 1 ? 
ATOM   926  C CZ3 . TRP A 1 113 ? 12.400 9.507  1.133   1.000 16.960 0  113  TRP A CZ3 1 ? 
ATOM   927  C CH2 . TRP A 1 113 ? 12.443 8.852  -0.099  1.000 17.390 0  113  TRP A CH2 1 ? 
ATOM   928  N N   . ILE A 1 114 ? 13.192 15.258 3.566   1.000 16.800 0  114  ILE A N   1 ? 
ATOM   929  C CA  . ILE A 1 114 ? 13.375 15.987 4.812   1.000 15.940 0  114  ILE A CA  1 ? 
ATOM   930  C C   . ILE A 1 114 ? 13.828 15.081 5.940   1.000 18.180 0  114  ILE A C   1 ? 
ATOM   931  O O   . ILE A 1 114 ? 14.081 15.568 7.040   1.000 17.480 0  114  ILE A O   1 ? 
ATOM   932  C CB  . ILE A 1 114 ? 12.097 16.739 5.201   1.000 16.500 0  114  ILE A CB  1 ? 
ATOM   933  C CG1 . ILE A 1 114 ? 10.905 15.785 5.397   1.000 18.150 0  114  ILE A CG1 1 ? 
ATOM   934  C CG2 . ILE A 1 114 ? 11.850 17.803 4.150   1.000 16.370 0  114  ILE A CG2 1 ? 
ATOM   935  C CD1 . ILE A 1 114 ? 9.717  16.397 6.139   1.000 19.200 0  114  ILE A CD1 1 ? 
ATOM   936  N N   . SER A 1 115 ? 13.875 13.768 5.697   1.000 16.950 0  115  SER A N   1 ? 
ATOM   937  C CA  . SER A 1 115 ? 14.314 12.802 6.680   1.000 16.620 0  115  SER A CA  1 ? 
ATOM   938  C C   . SER A 1 115 ? 14.729 11.536 5.932   1.000 15.230 0  115  SER A C   1 ? 
ATOM   939  O O   . SER A 1 115 ? 14.589 11.512 4.722   1.000 17.050 0  115  SER A O   1 ? 
ATOM   940  C CB  . SER A 1 115 ? 13.238 12.501 7.680   1.000 18.020 0  115  SER A CB  1 ? 
ATOM   941  O OG  . SER A 1 115 ? 12.209 11.734 7.103   1.000 20.710 0  115  SER A OG  1 ? 
ATOM   942  N N   . LEU A 1 116 ? 15.080 10.492 6.679   1.000 16.920 0  116  LEU A N   1 ? 
ATOM   943  C CA  . LEU A 1 116 ? 15.452 9.223  6.068   1.000 20.470 0  116  LEU A CA  1 ? 
ATOM   944  C C   . LEU A 1 116 ? 14.265 8.612  5.357   1.000 17.840 0  116  LEU A C   1 ? 
ATOM   945  O O   . LEU A 1 116 ? 14.467 7.731  4.512   1.000 18.820 0  116  LEU A O   1 ? 
ATOM   946  C CB  . LEU A 1 116 ? 15.928 8.204  7.090   1.000 22.490 0  116  LEU A CB  1 ? 
ATOM   947  C CG  . LEU A 1 116 ? 17.114 8.653  7.931   1.000 30.750 0  116  LEU A CG  1 ? 
ATOM   948  C CD1 . LEU A 1 116 ? 17.461 7.541  8.910   1.000 32.260 0  116  LEU A CD1 1 ? 
ATOM   949  C CD2 . LEU A 1 116 ? 18.260 8.998  7.017   1.000 34.360 0  116  LEU A CD2 1 ? 
ATOM   950  N N   . ASN A 1 117 ? 13.044 8.970  5.761   1.000 17.940 0  117  ASN A N   1 ? 
ATOM   951  C CA  . ASN A 1 117 ? 11.906 8.222  5.240   1.000 20.480 0  117  ASN A CA  1 ? 
ATOM   952  C C   . ASN A 1 117 ? 10.741 9.082  4.755   1.000 19.500 0  117  ASN A C   1 ? 
ATOM   953  O O   . ASN A 1 117 ? 9.679  8.525  4.406   1.000 20.530 0  117  ASN A O   1 ? 
ATOM   954  C CB  . ASN A 1 117 ? 11.439 7.183  6.239   1.000 22.620 0  117  ASN A CB  1 ? 
ATOM   955  C CG  . ASN A 1 117 ? 10.842 7.817  7.464   1.000 27.410 0  117  ASN A CG  1 ? 
ATOM   956  O OD1 . ASN A 1 117 ? 10.420 8.975  7.452   1.000 31.930 0  117  ASN A OD1 1 ? 
ATOM   957  N ND2 . ASN A 1 117 ? 10.768 7.047  8.533   1.000 38.800 0  117  ASN A ND2 1 ? 
ATOM   958  N N   . THR A 1 118 ? 10.938 10.404 4.665   1.000 17.140 0  118  THR A N   1 ? 
ATOM   959  C CA  . THR A 1 118 ? 9.859  11.310 4.264   1.000 16.530 0  118  THR A CA  1 ? 
ATOM   960  C C   . THR A 1 118 ? 10.362 12.308 3.226   1.000 17.280 0  118  THR A C   1 ? 
ATOM   961  O O   . THR A 1 118 ? 11.418 12.950 3.391   1.000 15.430 0  118  THR A O   1 ? 
ATOM   962  C CB  . THR A 1 118 ? 9.262  12.062 5.451   1.000 20.080 0  118  THR A CB  1 ? 
ATOM   963  O OG1 . THR A 1 118 ? 8.803  11.120 6.413   1.000 22.680 0  118  THR A OG1 1 ? 
ATOM   964  C CG2 . THR A 1 118 ? 8.149  12.994 5.026   1.000 18.850 0  118  THR A CG2 1 ? 
ATOM   965  N N   . VAL A 1 119 ? 9.559  12.404 2.170   1.000 16.730 0  119  VAL A N   1 ? 
ATOM   966  C CA  . VAL A 1 119 ? 9.748  13.364 1.080   1.000 18.450 0  119  VAL A CA  1 ? 
ATOM   967  C C   . VAL A 1 119 ? 8.755  14.514 1.240   1.000 18.220 0  119  VAL A C   1 ? 
ATOM   968  O O   . VAL A 1 119 ? 7.563  14.294 1.493   1.000 17.910 0  119  VAL A O   1 ? 
ATOM   969  C CB  . VAL A 1 119 ? 9.544  12.748 -0.324  1.000 23.040 0  119  VAL A CB  1 ? 
ATOM   970  C CG1 . VAL A 1 119 ? 9.953  13.753 -1.402  1.000 26.530 0  119  VAL A CG1 1 ? 
ATOM   971  C CG2 . VAL A 1 119 ? 10.333 11.482 -0.567  1.000 29.970 0  119  VAL A CG2 1 ? 
ATOM   972  N N   . ALA A 1 120 ? 9.224  15.766 1.087   1.000 15.180 0  120  ALA A N   1 ? 
ATOM   973  C CA  . ALA A 1 120 ? 8.316  16.904 1.105   1.000 14.230 0  120  ALA A CA  1 ? 
ATOM   974  C C   . ALA A 1 120 ? 8.027  17.313 -0.329  1.000 13.420 0  120  ALA A C   1 ? 
ATOM   975  O O   . ALA A 1 120 ? 8.934  17.390 -1.150  1.000 14.760 0  120  ALA A O   1 ? 
ATOM   976  C CB  . ALA A 1 120 ? 8.896  18.064 1.881   1.000 14.850 0  120  ALA A CB  1 ? 
ATOM   977  N N   . LEU A 1 121 ? 6.769  17.623 -0.607  1.000 14.840 0  121  LEU A N   1 ? 
ATOM   978  C CA  . LEU A 1 121 ? 6.300  18.015 -1.924  1.000 14.580 0  121  LEU A CA  1 ? 
ATOM   979  C C   . LEU A 1 121 ? 5.687  19.409 -1.885  1.000 13.920 0  121  LEU A C   1 ? 
ATOM   980  O O   . LEU A 1 121 ? 4.837  19.684 -1.036  1.000 15.580 0  121  LEU A O   1 ? 
ATOM   981  C CB  . LEU A 1 121 ? 5.223  17.032 -2.386  1.000 17.690 0  121  LEU A CB  1 ? 
ATOM   982  C CG  . LEU A 1 121 ? 5.479  15.543 -2.138  1.000 18.630 0  121  LEU A CG  1 ? 
ATOM   983  C CD1 . LEU A 1 121 ? 4.219  14.731 -2.422  1.000 23.130 0  121  LEU A CD1 1 ? 
ATOM   984  C CD2 . LEU A 1 121 ? 6.597  15.122 -3.027  1.000 20.490 0  121  LEU A CD2 1 ? 
ATOM   985  N N   . VAL A 1 122 ? 6.142  20.249 -2.807  1.000 13.150 0  122  VAL A N   1 ? 
ATOM   986  C CA  . VAL A 1 122 ? 5.645  21.598 -2.937  1.000 14.290 0  122  VAL A CA  1 ? 
ATOM   987  C C   . VAL A 1 122 ? 4.931  21.747 -4.274  1.000 16.200 0  122  VAL A C   1 ? 
ATOM   988  O O   . VAL A 1 122 ? 5.529  21.571 -5.328  1.000 19.160 0  122  VAL A O   1 ? 
ATOM   989  C CB  . VAL A 1 122 ? 6.759  22.643 -2.780  1.000 14.760 0  122  VAL A CB  1 ? 
ATOM   990  C CG1 . VAL A 1 122 ? 6.226  24.075 -2.796  1.000 15.340 0  122  VAL A CG1 1 ? 
ATOM   991  C CG2 . VAL A 1 122 ? 7.529  22.420 -1.484  1.000 14.710 0  122  VAL A CG2 1 ? 
ATOM   992  N N   . THR A 1 123 ? 3.679  22.203 -4.196  1.000 16.940 0  123  THR A N   1 ? 
ATOM   993  C CA  . THR A 1 123 ? 2.920  22.555 -5.395  1.000 20.220 0  123  THR A CA  1 ? 
ATOM   994  C C   . THR A 1 123 ? 2.836  24.070 -5.464  1.000 18.520 0  123  THR A C   1 ? 
ATOM   995  O O   . THR A 1 123 ? 3.280  24.776 -4.553  1.000 17.970 0  123  THR A O   1 ? 
ATOM   996  C CB  . THR A 1 123 ? 1.520  21.919 -5.376  1.000 20.350 0  123  THR A CB  1 ? 
ATOM   997  O OG1 . THR A 1 123 ? 0.723  22.535 -4.355  1.000 18.040 0  123  THR A OG1 1 ? 
ATOM   998  C CG2 . THR A 1 123 ? 1.575  20.404 -5.228  1.000 22.390 0  123  THR A CG2 1 ? 
ATOM   999  N N   . ASP A 1 124 ? 2.134  24.566 -6.489  1.000 20.710 0  124  ASP A N   1 ? 
ATOM   1000 C CA  . ASP A 1 124 ? 1.877  25.992 -6.540  1.000 21.510 0  124  ASP A CA  1 ? 
ATOM   1001 C C   . ASP A 1 124 ? 1.045  26.460 -5.335  1.000 19.460 0  124  ASP A C   1 ? 
ATOM   1002 O O   . ASP A 1 124 ? 1.110  27.631 -4.998  1.000 21.450 0  124  ASP A O   1 ? 
ATOM   1003 C CB  . ASP A 1 124 ? 1.148  26.357 -7.825  1.000 25.420 0  124  ASP A CB  1 ? 
ATOM   1004 C CG  . ASP A 1 124 ? 1.966  26.297 -9.104  1.000 29.250 0  124  ASP A CG  1 ? 
ATOM   1005 O OD1 . ASP A 1 124 ? 3.188  26.458 -9.026  1.000 29.440 0  124  ASP A OD1 1 ? 
ATOM   1006 O OD2 . ASP A 1 124 ? 1.361  26.049 -10.163 1.000 34.990 0  124  ASP A OD2 1 ? 
ATOM   1007 N N   . ASN A 1 125 ? 0.287  25.571 -4.692  1.000 18.750 0  125  ASN A N   1 ? 
ATOM   1008 C CA  . ASN A 1 125 ? -0.669 25.953 -3.673  1.000 21.990 0  125  ASN A CA  1 ? 
ATOM   1009 C C   . ASN A 1 125 ? -0.439 25.389 -2.275  1.000 18.790 0  125  ASN A C   1 ? 
ATOM   1010 O O   . ASN A 1 125 ? -1.008 25.921 -1.329  1.000 18.690 0  125  ASN A O   1 ? 
ATOM   1011 C CB  . ASN A 1 125 ? -2.053 25.410 -4.021  1.000 26.900 0  125  ASN A CB  1 ? 
ATOM   1012 C CG  . ASN A 1 125 ? -2.619 26.164 -5.200  1.000 38.580 0  125  ASN A CG  1 ? 
ATOM   1013 O OD1 . ASN A 1 125 ? -2.206 27.301 -5.460  1.000 35.990 0  125  ASN A OD1 1 ? 
ATOM   1014 N ND2 . ASN A 1 125 ? -3.490 25.524 -5.970  1.000 47.620 0  125  ASN A ND2 1 ? 
ATOM   1015 N N   . ALA A 1 126 ? 0.374  24.351 -2.106  1.000 19.680 0  126  ALA A N   1 ? 
ATOM   1016 C CA  . ALA A 1 126 ? 0.489  23.725 -0.799  1.000 15.690 0  126  ALA A CA  1 ? 
ATOM   1017 C C   . ALA A 1 126 ? 1.783  22.950 -0.663  1.000 14.540 0  126  ALA A C   1 ? 
ATOM   1018 O O   . ALA A 1 126 ? 2.475  22.692 -1.656  1.000 16.050 0  126  ALA A O   1 ? 
ATOM   1019 C CB  . ALA A 1 126 ? -0.663 22.773 -0.561  1.000 16.910 0  126  ALA A CB  1 ? 
ATOM   1020 N N   . VAL A 1 127 ? 1.996  22.514 0.579   1.000 14.640 0  127  VAL A N   1 ? 
ATOM   1021 C CA  . VAL A 1 127 ? 3.091  21.639 0.953   1.000 14.920 0  127  VAL A CA  1 ? 
ATOM   1022 C C   . VAL A 1 127 ? 2.564  20.356 1.578   1.000 15.400 0  127  VAL A C   1 ? 
ATOM   1023 O O   . VAL A 1 127 ? 1.727  20.401 2.460   1.000 16.270 0  127  VAL A O   1 ? 
ATOM   1024 C CB  . VAL A 1 127 ? 4.080  22.341 1.912   1.000 15.880 0  127  VAL A CB  1 ? 
ATOM   1025 C CG1 . VAL A 1 127 ? 5.154  21.367 2.346   1.000 16.830 0  127  VAL A CG1 1 ? 
ATOM   1026 C CG2 . VAL A 1 127 ? 4.681  23.562 1.272   1.000 16.990 0  127  VAL A CG2 1 ? 
ATOM   1027 N N   . TYR A 1 128 ? 3.112  19.216 1.150   1.000 15.770 0  128  TYR A N   1 ? 
ATOM   1028 C CA  . TYR A 1 128 ? 2.741  17.905 1.633   1.000 16.140 0  128  TYR A CA  1 ? 
ATOM   1029 C C   . TYR A 1 128 ? 3.971  17.173 2.145   1.000 16.970 0  128  TYR A C   1 ? 
ATOM   1030 O O   . TYR A 1 128 ? 5.057  17.422 1.639   1.000 15.220 0  128  TYR A O   1 ? 
ATOM   1031 C CB  . TYR A 1 128 ? 2.239  17.106 0.432   1.000 17.400 0  128  TYR A CB  1 ? 
ATOM   1032 C CG  . TYR A 1 128 ? 1.023  17.685 -0.267  1.000 18.700 0  128  TYR A CG  1 ? 
ATOM   1033 C CD1 . TYR A 1 128 ? 1.185  18.729 -1.165  1.000 20.740 0  128  TYR A CD1 1 ? 
ATOM   1034 C CD2 . TYR A 1 128 ? -0.264 17.191 -0.038  1.000 21.710 0  128  TYR A CD2 1 ? 
ATOM   1035 C CE1 . TYR A 1 128 ? 0.103  19.319 -1.792  1.000 23.080 0  128  TYR A CE1 1 ? 
ATOM   1036 C CE2 . TYR A 1 128 ? -1.359 17.732 -0.703  1.000 25.710 0  128  TYR A CE2 1 ? 
ATOM   1037 C CZ  . TYR A 1 128 ? -1.167 18.809 -1.558  1.000 24.850 0  128  TYR A CZ  1 ? 
ATOM   1038 O OH  . TYR A 1 128 ? -2.173 19.427 -2.205  1.000 27.260 0  128  TYR A OH  1 ? 
ATOM   1039 N N   . HIS A 1 129 ? 3.748  16.219 3.060   1.000 14.820 0  129  HIS A N   1 ? 
ATOM   1040 C CA  . HIS A 1 129 ? 4.765  15.279 3.464   1.000 14.890 0  129  HIS A CA  1 ? 
ATOM   1041 C C   . HIS A 1 129 ? 4.340  13.880 3.035   1.000 16.270 0  129  HIS A C   1 ? 
ATOM   1042 O O   . HIS A 1 129 ? 3.166  13.535 3.180   1.000 18.920 0  129  HIS A O   1 ? 
ATOM   1043 C CB  . HIS A 1 129 ? 4.979  15.296 4.965   1.000 15.320 0  129  HIS A CB  1 ? 
ATOM   1044 C CG  . HIS A 1 129 ? 5.678  16.514 5.437   1.000 13.580 0  129  HIS A CG  1 ? 
ATOM   1045 N ND1 . HIS A 1 129 ? 5.881  16.692 6.781   1.000 14.850 0  129  HIS A ND1 1 ? 
ATOM   1046 C CD2 . HIS A 1 129 ? 6.184  17.555 4.811   1.000 13.660 0  129  HIS A CD2 1 ? 
ATOM   1047 C CE1 . HIS A 1 129 ? 6.526  17.839 6.943   1.000 13.910 0  129  HIS A CE1 1 ? 
ATOM   1048 N NE2 . HIS A 1 129 ? 6.730  18.384 5.757   1.000 12.940 0  129  HIS A NE2 1 ? 
ATOM   1049 N N   . TRP A 1 130 ? 5.282  13.106 2.512   1.000 16.140 0  130  TRP A N   1 ? 
ATOM   1050 C CA  . TRP A 1 130 ? 4.997  11.745 2.053   1.000 18.520 0  130  TRP A CA  1 ? 
ATOM   1051 C C   . TRP A 1 130 ? 5.966  10.755 2.677   1.000 18.110 0  130  TRP A C   1 ? 
ATOM   1052 O O   . TRP A 1 130 ? 7.149  10.775 2.350   1.000 17.100 0  130  TRP A O   1 ? 
ATOM   1053 C CB  . TRP A 1 130 ? 5.085  11.686 0.530   1.000 19.890 0  130  TRP A CB  1 ? 
ATOM   1054 C CG  . TRP A 1 130 ? 4.601  10.395 -0.083  1.000 19.070 0  130  TRP A CG  1 ? 
ATOM   1055 C CD1 . TRP A 1 130 ? 3.820  9.421  0.452   1.000 20.650 0  130  TRP A CD1 1 ? 
ATOM   1056 C CD2 . TRP A 1 130 ? 4.894  9.986  -1.424  1.000 20.020 0  130  TRP A CD2 1 ? 
ATOM   1057 N NE1 . TRP A 1 130 ? 3.569  8.458  -0.496  1.000 21.050 0  130  TRP A NE1 1 ? 
ATOM   1058 C CE2 . TRP A 1 130 ? 4.236  8.761  -1.635  1.000 19.290 0  130  TRP A CE2 1 ? 
ATOM   1059 C CE3 . TRP A 1 130 ? 5.675  10.518 -2.452  1.000 20.990 0  130  TRP A CE3 1 ? 
ATOM   1060 C CZ2 . TRP A 1 130 ? 4.324  8.074  -2.836  1.000 21.960 0  130  TRP A CZ2 1 ? 
ATOM   1061 C CZ3 . TRP A 1 130 ? 5.764  9.832  -3.647  1.000 24.270 0  130  TRP A CZ3 1 ? 
ATOM   1062 C CH2 . TRP A 1 130 ? 5.079  8.630  -3.838  1.000 22.010 0  130  TRP A CH2 1 ? 
ATOM   1063 N N   . SER A 1 131 ? 5.475  9.982  3.652   1.000 17.690 0  131  SER A N   1 ? 
ATOM   1064 C CA  . SER A 1 131 ? 6.259  8.959  4.345   1.000 18.930 0  131  SER A CA  1 ? 
ATOM   1065 C C   . SER A 1 131 ? 6.402  7.733  3.447   1.000 18.570 0  131  SER A C   1 ? 
ATOM   1066 O O   . SER A 1 131 ? 5.461  7.357  2.761   1.000 18.340 0  131  SER A O   1 ? 
ATOM   1067 C CB  . SER A 1 131 ? 5.614  8.544  5.634   1.000 21.780 0  131  SER A CB  1 ? 
ATOM   1068 O OG  . SER A 1 131 ? 6.237  7.380  6.179   1.000 22.280 0  131  SER A OG  1 ? 
ATOM   1069 N N   . MET A 1 132 ? 7.558  7.084  3.507   1.000 17.870 0  132  MET A N   1 ? 
ATOM   1070 C CA  . MET A 1 132 ? 7.761  5.868  2.758   1.000 19.760 0  132  MET A CA  1 ? 
ATOM   1071 C C   . MET A 1 132 ? 7.254  4.652  3.527   1.000 22.920 0  132  MET A C   1 ? 
ATOM   1072 O O   . MET A 1 132 ? 7.353  3.566  2.982   1.000 25.570 0  132  MET A O   1 ? 
ATOM   1073 C CB  . MET A 1 132 ? 9.249  5.694  2.448   1.000 21.990 0  132  MET A CB  1 ? 
ATOM   1074 C CG  . MET A 1 132 ? 9.789  6.798  1.550   1.000 19.380 0  132  MET A CG  1 ? 
ATOM   1075 S SD  . MET A 1 132 ? 9.024  6.887  -0.065  1.000 22.460 0  132  MET A SD  1 ? 
ATOM   1076 C CE  . MET A 1 132 ? 7.747  8.154  -0.049  1.000 21.110 0  132  MET A CE  1 ? 
ATOM   1077 N N   . GLU A 1 133 ? 6.728  4.822  4.748   1.000 22.350 0  133  GLU A N   1 ? 
ATOM   1078 C CA  . GLU A 1 133 ? 6.316  3.676  5.546   1.000 29.340 0  133  GLU A CA  1 ? 
ATOM   1079 C C   . GLU A 1 133 ? 4.999  3.108  5.040   1.000 29.940 0  133  GLU A C   1 ? 
ATOM   1080 O O   . GLU A 1 133 ? 4.103  3.832  4.643   1.000 29.700 0  133  GLU A O   1 ? 
ATOM   1081 C CB  . GLU A 1 133 ? 6.352  4.004  7.036   1.000 34.080 0  133  GLU A CB  1 ? 
ATOM   1082 C CG  . GLU A 1 133 ? 7.808  4.002  7.508   1.000 45.160 0  133  GLU A CG  1 ? 
ATOM   1083 C CD  . GLU A 1 133 ? 8.155  3.963  8.988   1.000 51.440 0  133  GLU A CD  1 ? 
ATOM   1084 O OE1 . GLU A 1 133 ? 8.079  5.051  9.613   1.000 58.690 0  133  GLU A OE1 1 ? 
ATOM   1085 O OE2 . GLU A 1 133 ? 8.515  2.863  9.502   1.000 40.490 0  133  GLU A OE2 1 ? 
ATOM   1086 N N   . GLY A 1 134 ? 4.895  1.785  5.016   1.000 32.680 0  134  GLY A N   1 ? 
ATOM   1087 C CA  . GLY A 1 134 ? 3.640  1.132  4.674   1.000 30.750 0  134  GLY A CA  1 ? 
ATOM   1088 C C   . GLY A 1 134 ? 3.035  1.669  3.382   1.000 35.180 0  134  GLY A C   1 ? 
ATOM   1089 O O   . GLY A 1 134 ? 3.722  1.857  2.375   1.000 38.140 0  134  GLY A O   1 ? 
ATOM   1090 N N   . GLU A 1 135 ? 1.727  1.925  3.434   1.000 31.880 0  135  GLU A N   1 ? 
ATOM   1091 C CA  . GLU A 1 135 ? 0.974  2.387  2.279   1.000 36.190 0  135  GLU A CA  1 ? 
ATOM   1092 C C   . GLU A 1 135 ? 0.629  3.874  2.403   1.000 32.610 0  135  GLU A C   1 ? 
ATOM   1093 O O   . GLU A 1 135 ? -0.224 4.390  1.691   1.000 32.400 0  135  GLU A O   1 ? 
ATOM   1094 C CB  . GLU A 1 135 ? -0.281 1.516  2.181   1.000 47.520 0  135  GLU A CB  1 ? 
ATOM   1095 C CG  . GLU A 1 135 ? 0.031  0.024  2.075   1.000 56.710 0  135  GLU A CG  1 ? 
ATOM   1096 C CD  . GLU A 1 135 ? -1.175 -0.856 2.357   1.000 70.420 0  135  GLU A CD  1 ? 
ATOM   1097 O OE1 . GLU A 1 135 ? -1.666 -0.834 3.513   1.000 79.180 0  135  GLU A OE1 1 ? 
ATOM   1098 O OE2 . GLU A 1 135 ? -1.625 -1.554 1.421   1.000 74.350 0  135  GLU A OE2 1 ? 
ATOM   1099 N N   . SER A 1 136 ? 1.373  4.601  3.229   1.000 30.540 0  136  SER A N   1 ? 
ATOM   1100 C CA  . SER A 1 136 ? 1.191  6.046  3.368   1.000 30.260 0  136  SER A CA  1 ? 
ATOM   1101 C C   . SER A 1 136 ? 1.090  6.773  2.025   1.000 26.490 0  136  SER A C   1 ? 
ATOM   1102 O O   . SER A 1 136 ? 1.904  6.575  1.126   1.000 25.780 0  136  SER A O   1 ? 
ATOM   1103 C CB  . SER A 1 136 ? 2.344  6.620  4.160   1.000 29.780 0  136  SER A CB  1 ? 
ATOM   1104 O OG  . SER A 1 136 ? 2.568  5.853  5.326   1.000 34.040 0  136  SER A OG  1 ? 
ATOM   1105 N N   . GLN A 1 137 ? 0.143  7.703  1.934   1.000 25.880 0  137  GLN A N   1 ? 
ATOM   1106 C CA  . GLN A 1 137 ? 0.048  8.631  0.819   1.000 26.590 0  137  GLN A CA  1 ? 
ATOM   1107 C C   . GLN A 1 137 ? 0.489  10.017 1.288   1.000 22.130 0  137  GLN A C   1 ? 
ATOM   1108 O O   . GLN A 1 137 ? 0.529  10.258 2.498   1.000 25.020 0  137  GLN A O   1 ? 
ATOM   1109 C CB  . GLN A 1 137 ? -1.387 8.688  0.310   1.000 31.310 0  137  GLN A CB  1 ? 
ATOM   1110 C CG  . GLN A 1 137 ? -1.824 7.366  -0.318  1.000 36.170 0  137  GLN A CG  1 ? 
ATOM   1111 C CD  . GLN A 1 137 ? -3.082 7.492  -1.146  1.000 44.650 0  137  GLN A CD  1 ? 
ATOM   1112 O OE1 . GLN A 1 137 ? -3.634 8.580  -1.354  1.000 49.720 0  137  GLN A OE1 1 ? 
ATOM   1113 N NE2 . GLN A 1 137 ? -3.556 6.349  -1.613  1.000 52.790 0  137  GLN A NE2 1 ? 
ATOM   1114 N N   . PRO A 1 138 ? 0.757  10.985 0.371   1.000 23.290 0  138  PRO A N   1 ? 
ATOM   1115 C CA  . PRO A 1 138 ? 1.090  12.363 0.780   1.000 20.680 0  138  PRO A CA  1 ? 
ATOM   1116 C C   . PRO A 1 138 ? -0.000 12.992 1.630   1.000 22.410 0  138  PRO A C   1 ? 
ATOM   1117 O O   . PRO A 1 138 ? -1.190 12.826 1.363   1.000 22.710 0  138  PRO A O   1 ? 
ATOM   1118 C CB  . PRO A 1 138 ? 1.285  13.108 -0.564  1.000 22.050 0  138  PRO A CB  1 ? 
ATOM   1119 C CG  . PRO A 1 138 ? 1.647  12.036 -1.553  1.000 23.740 0  138  PRO A CG  1 ? 
ATOM   1120 C CD  . PRO A 1 138 ? 0.831  10.821 -1.089  1.000 23.200 0  138  PRO A CD  1 ? 
ATOM   1121 N N   . VAL A 1 139 ? 0.413  13.683 2.692   1.000 19.690 0  139  VAL A N   1 ? 
ATOM   1122 C CA  . VAL A 1 139 ? -0.472 14.371 3.601   1.000 21.220 0  139  VAL A CA  1 ? 
ATOM   1123 C C   . VAL A 1 139 ? -0.199 15.856 3.475   1.000 21.390 0  139  VAL A C   1 ? 
ATOM   1124 O O   . VAL A 1 139 ? 0.957  16.270 3.515   1.000 18.640 0  139  VAL A O   1 ? 
ATOM   1125 C CB  . VAL A 1 139 ? -0.200 13.891 5.033   1.000 24.680 0  139  VAL A CB  1 ? 
ATOM   1126 C CG1 . VAL A 1 139 ? -1.028 14.680 6.049   1.000 25.520 0  139  VAL A CG1 1 ? 
ATOM   1127 C CG2 . VAL A 1 139 ? -0.456 12.394 5.158   1.000 27.090 0  139  VAL A CG2 1 ? 
ATOM   1128 N N   . LYS A 1 140 ? -1.247 16.656 3.275   1.000 19.290 0  140  LYS A N   1 ? 
ATOM   1129 C CA  . LYS A 1 140 ? -1.051 18.086 3.173   1.000 19.370 0  140  LYS A CA  1 ? 
ATOM   1130 C C   . LYS A 1 140 ? -0.696 18.644 4.541   1.000 19.770 0  140  LYS A C   1 ? 
ATOM   1131 O O   . LYS A 1 140 ? -1.390 18.390 5.521   1.000 18.970 0  140  LYS A O   1 ? 
ATOM   1132 C CB  . LYS A 1 140 ? -2.277 18.796 2.590   1.000 23.340 0  140  LYS A CB  1 ? 
ATOM   1133 C CG  . LYS A 1 140 ? -2.144 20.298 2.440   1.000 25.980 0  140  LYS A CG  1 ? 
ATOM   1134 C CD  . LYS A 1 140 ? -3.235 20.903 1.550   1.000 31.300 0  140  LYS A CD  1 ? 
ATOM   1135 C CE  . LYS A 1 140 ? -4.265 21.633 2.232   1.000 36.650 0  140  LYS A CE  1 ? 
ATOM   1136 N NZ  . LYS A 1 140 ? -5.063 22.222 1.150   1.000 39.570 0  140  LYS A NZ  1 ? 
ATOM   1137 N N   . MET A 1 141 ? 0.393  19.435 4.587   1.000 17.830 0  141  MET A N   1 ? 
ATOM   1138 C CA  . MET A 1 141 ? 0.834  20.060 5.811   1.000 18.260 0  141  MET A CA  1 ? 
ATOM   1139 C C   . MET A 1 141 ? 0.239  21.457 5.942   1.000 17.280 0  141  MET A C   1 ? 
ATOM   1140 O O   . MET A 1 141 ? -0.190 21.806 7.037   1.000 18.540 0  141  MET A O   1 ? 
ATOM   1141 C CB  . MET A 1 141 ? 2.356  20.048 5.914   1.000 18.340 0  141  MET A CB  1 ? 
ATOM   1142 C CG  . MET A 1 141 ? 2.917  18.611 5.804   1.000 18.180 0  141  MET A CG  1 ? 
ATOM   1143 S SD  . MET A 1 141 ? 2.277  17.424 7.000   1.000 21.020 0  141  MET A SD  1 ? 
ATOM   1144 C CE  . MET A 1 141 ? 2.926  18.161 8.503   1.000 19.400 0  141  MET A CE  1 ? 
ATOM   1145 N N   . PHE A 1 142 ? 0.294  22.265 4.878   1.000 15.370 0  142  PHE A N   1 ? 
ATOM   1146 C CA  . PHE A 1 142 ? -0.139 23.645 4.947   1.000 15.390 0  142  PHE A CA  1 ? 
ATOM   1147 C C   . PHE A 1 142 ? -0.320 24.158 3.537   1.000 15.390 0  142  PHE A C   1 ? 
ATOM   1148 O O   . PHE A 1 142 ? 0.208  23.589 2.563   1.000 15.080 0  142  PHE A O   1 ? 
ATOM   1149 C CB  . PHE A 1 142 ? 0.779  24.554 5.771   1.000 15.880 0  142  PHE A CB  1 ? 
ATOM   1150 C CG  . PHE A 1 142 ? 2.215  24.697 5.269   1.000 14.380 0  142  PHE A CG  1 ? 
ATOM   1151 C CD1 . PHE A 1 142 ? 2.532  25.697 4.351   1.000 16.060 0  142  PHE A CD1 1 ? 
ATOM   1152 C CD2 . PHE A 1 142 ? 3.201  23.816 5.720   1.000 14.940 0  142  PHE A CD2 1 ? 
ATOM   1153 C CE1 . PHE A 1 142 ? 3.843  25.842 3.908   1.000 15.240 0  142  PHE A CE1 1 ? 
ATOM   1154 C CE2 . PHE A 1 142 ? 4.514  23.969 5.290   1.000 15.180 0  142  PHE A CE2 1 ? 
ATOM   1155 C CZ  . PHE A 1 142 ? 4.825  24.987 4.400   1.000 13.530 0  142  PHE A CZ  1 ? 
ATOM   1156 N N   . ASP A 1 143 ? -1.178 25.179 3.439   1.000 15.380 0  143  ASP A N   1 ? 
ATOM   1157 C CA  . ASP A 1 143 ? -1.342 25.972 2.248   1.000 17.560 0  143  ASP A CA  1 ? 
ATOM   1158 C C   . ASP A 1 143 ? -0.288 27.076 2.218   1.000 15.560 0  143  ASP A C   1 ? 
ATOM   1159 O O   . ASP A 1 143 ? -0.005 27.754 3.219   1.000 16.920 0  143  ASP A O   1 ? 
ATOM   1160 C CB  . ASP A 1 143 ? -2.721 26.614 2.176   1.000 21.350 0  143  ASP A CB  1 ? 
ATOM   1161 C CG  . ASP A 1 143 ? -3.858 25.609 2.080   1.000 27.410 0  143  ASP A CG  1 ? 
ATOM   1162 O OD1 . ASP A 1 143 ? -3.754 24.655 1.272   1.000 27.260 0  143  ASP A OD1 1 ? 
ATOM   1163 O OD2 . ASP A 1 143 ? -4.801 25.784 2.843   1.000 36.540 0  143  ASP A OD2 1 ? 
ATOM   1164 N N   . ARG A 1 144 ? 0.217  27.281 1.011   1.000 16.890 0  144  ARG A N   1 ? 
ATOM   1165 C CA  . ARG A 1 144 ? 1.202  28.319 0.742   1.000 17.480 0  144  ARG A CA  1 ? 
ATOM   1166 C C   . ARG A 1 144 ? 0.661  29.724 0.962   1.000 18.580 0  144  ARG A C   1 ? 
ATOM   1167 O O   . ARG A 1 144 ? -0.463 30.040 0.590   1.000 18.720 0  144  ARG A O   1 ? 
ATOM   1168 C CB  . ARG A 1 144 ? 1.739  28.221 -0.673  1.000 17.240 0  144  ARG A CB  1 ? 
ATOM   1169 C CG  . ARG A 1 144 ? 2.795  27.143 -0.794  1.000 16.860 0  144  ARG A CG  1 ? 
ATOM   1170 C CD  . ARG A 1 144 ? 3.216  26.977 -2.243  1.000 17.260 0  144  ARG A CD  1 ? 
ATOM   1171 N NE  . ARG A 1 144 ? 3.808  28.203 -2.796  1.000 17.840 0  144  ARG A NE  1 ? 
ATOM   1172 C CZ  . ARG A 1 144 ? 4.468  28.291 -3.931  1.000 17.410 0  144  ARG A CZ  1 ? 
ATOM   1173 N NH1 . ARG A 1 144 ? 4.718  27.212 -4.652  1.000 19.040 0  144  ARG A NH1 1 ? 
ATOM   1174 N NH2 . ARG A 1 144 ? 4.838  29.470 -4.376  1.000 17.150 0  144  ARG A NH2 1 ? 
ATOM   1175 N N   . HIS A 1 145 ? 1.496  30.554 1.570   1.000 18.340 0  145  HIS A N   1 ? 
ATOM   1176 C CA  . HIS A 1 145 ? 1.171  31.928 1.907   1.000 20.200 0  145  HIS A CA  1 ? 
ATOM   1177 C C   . HIS A 1 145 ? 1.332  32.783 0.669   1.000 22.540 0  145  HIS A C   1 ? 
ATOM   1178 O O   . HIS A 1 145 ? 2.172  32.467 -0.205  1.000 23.660 0  145  HIS A O   1 ? 
ATOM   1179 C CB  . HIS A 1 145 ? 2.091  32.420 3.023   1.000 19.360 0  145  HIS A CB  1 ? 
ATOM   1180 C CG  . HIS A 1 145 ? 1.707  33.743 3.566   1.000 21.680 0  145  HIS A CG  1 ? 
ATOM   1181 N ND1 . HIS A 1 145 ? 2.130  34.913 2.980   1.000 19.750 0  145  HIS A ND1 1 ? 
ATOM   1182 C CD2 . HIS A 1 145 ? 0.919  34.093 4.633   1.000 26.780 0  145  HIS A CD2 1 ? 
ATOM   1183 C CE1 . HIS A 1 145 ? 1.589  35.948 3.665   1.000 25.180 0  145  HIS A CE1 1 ? 
ATOM   1184 N NE2 . HIS A 1 145 ? 0.869  35.478 4.690   1.000 24.580 0  145  HIS A NE2 1 ? 
ATOM   1185 N N   . SER A 1 146 ? 0.461  33.823 0.523   1.000 19.930 0  146  SER A N   1 ? 
ATOM   1186 C CA  . SER A 1 146 ? 0.446  34.591 -0.714  1.000 21.230 0  146  SER A CA  1 ? 
ATOM   1187 C C   . SER A 1 146 ? 1.766  35.344 -0.942  1.000 20.190 0  146  SER A C   1 ? 
ATOM   1188 O O   . SER A 1 146 ? 2.096  35.735 -2.046  1.000 19.820 0  146  SER A O   1 ? 
ATOM   1189 C CB  . SER A 1 146 ? -0.693 35.612 -0.732  1.000 24.610 0  146  SER A CB  1 ? 
ATOM   1190 O OG  . SER A 1 146 ? -0.541 36.451 0.400   1.000 24.560 0  146  SER A OG  1 ? 
ATOM   1191 N N   . SER A 1 147 ? 2.539  35.580 0.099   1.000 19.930 0  147  SER A N   1 ? 
ATOM   1192 C CA  . SER A 1 147 ? 3.808  36.256 -0.071  1.000 21.190 0  147  SER A CA  1 ? 
ATOM   1193 C C   . SER A 1 147 ? 4.829  35.413 -0.861  1.000 21.060 0  147  SER A C   1 ? 
ATOM   1194 O O   . SER A 1 147 ? 5.815  35.971 -1.351  1.000 19.020 0  147  SER A O   1 ? 
ATOM   1195 C CB  . SER A 1 147 ? 4.351  36.692 1.254   1.000 23.270 0  147  SER A CB  1 ? 
ATOM   1196 O OG  . SER A 1 147 ? 4.704  35.557 2.030   1.000 21.050 0  147  SER A OG  1 ? 
ATOM   1197 N N   . LEU A 1 148 ? 4.608  34.104 -1.059  1.000 18.030 0  148  LEU A N   1 ? 
ATOM   1198 C CA  . LEU A 1 148 ? 5.539  33.306 -1.866  1.000 17.850 0  148  LEU A CA  1 ? 
ATOM   1199 C C   . LEU A 1 148 ? 5.011  33.156 -3.291  1.000 17.750 0  148  LEU A C   1 ? 
ATOM   1200 O O   . LEU A 1 148 ? 5.586  32.444 -4.120  1.000 17.480 0  148  LEU A O   1 ? 
ATOM   1201 C CB  . LEU A 1 148 ? 5.821  31.946 -1.226  1.000 16.820 0  148  LEU A CB  1 ? 
ATOM   1202 C CG  . LEU A 1 148 ? 6.940  31.976 -0.185  1.000 19.370 0  148  LEU A CG  1 ? 
ATOM   1203 C CD1 . LEU A 1 148 ? 6.495  32.680 1.117   1.000 18.800 0  148  LEU A CD1 1 ? 
ATOM   1204 C CD2 . LEU A 1 148 ? 7.480  30.610 0.103   1.000 23.150 0  148  LEU A CD2 1 ? 
ATOM   1205 N N   . ALA A 1 149 ? 3.921  33.860 -3.633  1.000 18.590 0  149  ALA A N   1 ? 
ATOM   1206 C CA  . ALA A 1 149 ? 3.370  33.656 -4.960  1.000 20.240 0  149  ALA A CA  1 ? 
ATOM   1207 C C   . ALA A 1 149 ? 4.354  34.205 -6.002  1.000 18.980 0  149  ALA A C   1 ? 
ATOM   1208 O O   . ALA A 1 149 ? 4.924  35.294 -5.867  1.000 21.360 0  149  ALA A O   1 ? 
ATOM   1209 C CB  . ALA A 1 149 ? 2.001  34.316 -5.053  1.000 25.440 0  149  ALA A CB  1 ? 
ATOM   1210 N N   . GLY A 1 150 ? 4.557  33.446 -7.059  1.000 21.820 0  150  GLY A N   1 ? 
ATOM   1211 C CA  . GLY A 1 150 ? 5.461  33.872 -8.120  1.000 22.440 0  150  GLY A CA  1 ? 
ATOM   1212 C C   . GLY A 1 150 ? 6.942  33.678 -7.774  1.000 25.150 0  150  GLY A C   1 ? 
ATOM   1213 O O   . GLY A 1 150 ? 7.801  33.968 -8.609  1.000 25.890 0  150  GLY A O   1 ? 
ATOM   1214 N N   . CYS A 1 151 ? 7.264  33.185 -6.570  1.000 19.090 0  151  CYS A N   1 ? 
ATOM   1215 C CA  . CYS A 1 151 ? 8.651  32.959 -6.193  1.000 19.870 0  151  CYS A CA  1 ? 
ATOM   1216 C C   . CYS A 1 151 ? 9.184  31.688 -6.829  1.000 18.190 0  151  CYS A C   1 ? 
ATOM   1217 O O   . CYS A 1 151 ? 8.457  30.714 -7.051  1.000 20.610 0  151  CYS A O   1 ? 
ATOM   1218 C CB  . CYS A 1 151 ? 8.813  32.861 -4.678  1.000 21.550 0  151  CYS A CB  1 ? 
ATOM   1219 S SG  . CYS A 1 151 ? 8.493  34.437 -3.838  1.000 27.020 0  151  CYS A SG  1 ? 
ATOM   1220 N N   . GLN A 1 152 ? 10.489 31.684 -7.114  1.000 16.780 0  152  GLN A N   1 ? 
ATOM   1221 C CA  . GLN A 1 152 ? 11.200 30.429 -7.319  1.000 15.910 0  152  GLN A CA  1 ? 
ATOM   1222 C C   . GLN A 1 152 ? 11.420 29.761 -5.956  1.000 16.100 0  152  GLN A C   1 ? 
ATOM   1223 O O   . GLN A 1 152 ? 12.110 30.322 -5.109  1.000 15.120 0  152  GLN A O   1 ? 
ATOM   1224 C CB  . GLN A 1 152 ? 12.556 30.745 -7.935  1.000 17.850 0  152  GLN A CB  1 ? 
ATOM   1225 C CG  . GLN A 1 152 ? 13.360 29.480 -8.184  1.000 19.570 0  152  GLN A CG  1 ? 
ATOM   1226 C CD  . GLN A 1 152 ? 14.766 29.745 -8.645  1.000 21.170 0  152  GLN A CD  1 ? 
ATOM   1227 O OE1 . GLN A 1 152 ? 15.301 30.834 -8.485  1.000 23.030 0  152  GLN A OE1 1 ? 
ATOM   1228 N NE2 . GLN A 1 152 ? 15.399 28.707 -9.169  1.000 26.860 0  152  GLN A NE2 1 ? 
ATOM   1229 N N   . ILE A 1 153 ? 10.876 28.565 -5.761  1.000 15.090 0  153  ILE A N   1 ? 
ATOM   1230 C CA  . ILE A 1 153 ? 11.089 27.840 -4.514  1.000 15.420 0  153  ILE A CA  1 ? 
ATOM   1231 C C   . ILE A 1 153 ? 12.489 27.240 -4.520  1.000 16.290 0  153  ILE A C   1 ? 
ATOM   1232 O O   . ILE A 1 153 ? 12.867 26.516 -5.441  1.000 18.520 0  153  ILE A O   1 ? 
ATOM   1233 C CB  . ILE A 1 153 ? 10.027 26.753 -4.316  1.000 15.890 0  153  ILE A CB  1 ? 
ATOM   1234 C CG1 . ILE A 1 153 ? 8.596  27.327 -4.271  1.000 17.490 0  153  ILE A CG1 1 ? 
ATOM   1235 C CG2 . ILE A 1 153 ? 10.334 25.896 -3.103  1.000 14.990 0  153  ILE A CG2 1 ? 
ATOM   1236 C CD1 . ILE A 1 153 ? 8.354  28.363 -3.166  1.000 17.700 0  153  ILE A CD1 1 ? 
ATOM   1237 N N   . ILE A 1 154 ? 13.262 27.540 -3.475  1.000 14.780 0  154  ILE A N   1 ? 
ATOM   1238 C CA  . ILE A 1 154 ? 14.640 27.112 -3.407  1.000 15.380 0  154  ILE A CA  1 ? 
ATOM   1239 C C   . ILE A 1 154 ? 14.904 26.166 -2.267  1.000 14.730 0  154  ILE A C   1 ? 
ATOM   1240 O O   . ILE A 1 154 ? 15.959 25.555 -2.256  1.000 14.420 0  154  ILE A O   1 ? 
ATOM   1241 C CB  . ILE A 1 154 ? 15.612 28.300 -3.384  1.000 17.200 0  154  ILE A CB  1 ? 
ATOM   1242 C CG1 . ILE A 1 154 ? 15.395 29.209 -2.152  1.000 17.940 0  154  ILE A CG1 1 ? 
ATOM   1243 C CG2 . ILE A 1 154 ? 15.515 29.024 -4.712  1.000 20.460 0  154  ILE A CG2 1 ? 
ATOM   1244 C CD1 . ILE A 1 154 ? 16.473 30.240 -1.923  1.000 20.240 0  154  ILE A CD1 1 ? 
ATOM   1245 N N   . ASN A 1 155 ? 14.061 26.121 -1.239  1.000 13.530 0  155  ASN A N   1 ? 
ATOM   1246 C CA  . ASN A 1 155 ? 14.359 25.235 -0.132  1.000 15.460 0  155  ASN A CA  1 ? 
ATOM   1247 C C   . ASN A 1 155 ? 13.075 24.949 0.651   1.000 13.760 0  155  ASN A C   1 ? 
ATOM   1248 O O   . ASN A 1 155 ? 12.114 25.706 0.607   1.000 13.280 0  155  ASN A O   1 ? 
ATOM   1249 C CB  . ASN A 1 155 ? 15.439 25.857 0.745   1.000 17.910 0  155  ASN A CB  1 ? 
ATOM   1250 C CG  . ASN A 1 155 ? 15.851 24.965 1.886   1.000 26.430 0  155  ASN A CG  1 ? 
ATOM   1251 O OD1 . ASN A 1 155 ? 15.624 25.319 3.063   1.000 27.530 0  155  ASN A OD1 1 ? 
ATOM   1252 N ND2 . ASN A 1 155 ? 16.265 23.759 1.563   1.000 18.120 0  155  ASN A ND2 1 ? 
ATOM   1253 N N   . TYR A 1 156 ? 13.137 23.860 1.392   1.000 13.000 0  156  TYR A N   1 ? 
ATOM   1254 C CA  . TYR A 1 156 ? 12.120 23.446 2.346   1.000 12.650 0  156  TYR A CA  1 ? 
ATOM   1255 C C   . TYR A 1 156 ? 12.838 22.665 3.414   1.000 13.810 0  156  TYR A C   1 ? 
ATOM   1256 O O   . TYR A 1 156 ? 13.598 21.744 3.110   1.000 15.180 0  156  TYR A O   1 ? 
ATOM   1257 C CB  . TYR A 1 156 ? 11.020 22.592 1.712   1.000 12.020 0  156  TYR A CB  1 ? 
ATOM   1258 C CG  . TYR A 1 156 ? 10.000 22.163 2.742   1.000 12.860 0  156  TYR A CG  1 ? 
ATOM   1259 C CD1 . TYR A 1 156 ? 9.063  23.087 3.193   1.000 12.960 0  156  TYR A CD1 1 ? 
ATOM   1260 C CD2 . TYR A 1 156 ? 9.978  20.885 3.282   1.000 13.550 0  156  TYR A CD2 1 ? 
ATOM   1261 C CE1 . TYR A 1 156 ? 8.125  22.729 4.123   1.000 13.070 0  156  TYR A CE1 1 ? 
ATOM   1262 C CE2 . TYR A 1 156 ? 9.034  20.514 4.227   1.000 13.530 0  156  TYR A CE2 1 ? 
ATOM   1263 C CZ  . TYR A 1 156 ? 8.094  21.445 4.641   1.000 13.090 0  156  TYR A CZ  1 ? 
ATOM   1264 O OH  . TYR A 1 156 ? 7.108  21.136 5.539   1.000 13.230 0  156  TYR A OH  1 ? 
ATOM   1265 N N   . ARG A 1 157 ? 12.622 23.041 4.673   1.000 14.560 0  157  ARG A N   1 ? 
ATOM   1266 C CA  . ARG A 1 157 ? 13.181 22.254 5.743   1.000 18.040 0  157  ARG A CA  1 ? 
ATOM   1267 C C   . ARG A 1 157 ? 12.331 22.326 6.998   1.000 14.840 0  157  ARG A C   1 ? 
ATOM   1268 O O   . ARG A 1 157 ? 11.398 23.141 7.081   1.000 14.020 0  157  ARG A O   1 ? 
ATOM   1269 C CB  . ARG A 1 157 ? 14.616 22.628 6.067   1.000 23.530 0  157  ARG A CB  1 ? 
ATOM   1270 C CG  . ARG A 1 157 ? 14.928 24.068 6.354   1.000 22.370 0  157  ARG A CG  1 ? 
ATOM   1271 C CD  . ARG A 1 157 ? 16.424 24.251 5.981   1.000 24.420 0  157  ARG A CD  1 ? 
ATOM   1272 N NE  . ARG A 1 157 ? 17.353 23.266 6.546   1.000 24.500 0  157  ARG A NE  1 ? 
ATOM   1273 C CZ  . ARG A 1 157 ? 18.674 23.161 6.290   1.000 23.920 0  157  ARG A CZ  1 ? 
ATOM   1274 N NH1 . ARG A 1 157 ? 19.364 24.131 5.734   1.000 23.390 0  157  ARG A NH1 1 ? 
ATOM   1275 N NH2 . ARG A 1 157 ? 19.329 22.107 6.703   1.000 25.510 0  157  ARG A NH2 1 ? 
ATOM   1276 N N   . THR A 1 158 ? 12.693 21.441 7.930   1.000 13.860 0  158  THR A N   1 ? 
ATOM   1277 C CA  . THR A 1 158 ? 11.920 21.265 9.145   1.000 13.950 0  158  THR A CA  1 ? 
ATOM   1278 C C   . THR A 1 158 ? 12.865 21.154 10.329  1.000 13.780 0  158  THR A C   1 ? 
ATOM   1279 O O   . THR A 1 158 ? 14.067 20.851 10.196  1.000 14.410 0  158  THR A O   1 ? 
ATOM   1280 C CB  . THR A 1 158 ? 10.981 20.048 9.067   1.000 14.440 0  158  THR A CB  1 ? 
ATOM   1281 O OG1 . THR A 1 158 ? 11.683 18.852 9.412   1.000 17.240 0  158  THR A OG1 1 ? 
ATOM   1282 C CG2 . THR A 1 158 ? 10.333 19.961 7.692   1.000 14.880 0  158  THR A CG2 1 ? 
ATOM   1283 N N   . ASP A 1 159 ? 12.298 21.337 11.519  1.000 12.280 0  159  ASP A N   1 ? 
ATOM   1284 C CA  . ASP A 1 159 ? 12.985 20.914 12.705  1.000 13.970 0  159  ASP A CA  1 ? 
ATOM   1285 C C   . ASP A 1 159 ? 12.972 19.389 12.836  1.000 15.340 0  159  ASP A C   1 ? 
ATOM   1286 O O   . ASP A 1 159 ? 12.334 18.652 12.089  1.000 15.350 0  159  ASP A O   1 ? 
ATOM   1287 C CB  . ASP A 1 159 ? 12.391 21.560 13.939  1.000 16.230 0  159  ASP A CB  1 ? 
ATOM   1288 C CG  . ASP A 1 159 ? 11.046 20.952 14.341  1.000 16.920 0  159  ASP A CG  1 ? 
ATOM   1289 O OD1 . ASP A 1 159 ? 10.209 20.736 13.460  1.000 17.630 0  159  ASP A OD1 1 ? 
ATOM   1290 O OD2 . ASP A 1 159 ? 10.810 20.819 15.558  1.000 22.910 0  159  ASP A OD2 1 ? 
ATOM   1291 N N   . ALA A 1 160 ? 13.731 18.902 13.803  1.000 18.940 0  160  ALA A N   1 ? 
ATOM   1292 C CA  . ALA A 1 160 ? 13.942 17.466 13.968  1.000 21.140 0  160  ALA A CA  1 ? 
ATOM   1293 C C   . ALA A 1 160 ? 12.622 16.727 14.210  1.000 20.670 0  160  ALA A C   1 ? 
ATOM   1294 O O   . ALA A 1 160 ? 12.375 15.653 13.638  1.000 20.750 0  160  ALA A O   1 ? 
ATOM   1295 C CB  . ALA A 1 160 ? 14.927 17.256 15.104  1.000 22.110 0  160  ALA A CB  1 ? 
ATOM   1296 N N   . LYS A 1 161 ? 11.714 17.381 14.940  1.000 20.500 0  161  LYS A N   1 ? 
ATOM   1297 C CA  . LYS A 1 161 ? 10.439 16.767 15.286  1.000 22.100 0  161  LYS A CA  1 ? 
ATOM   1298 C C   . LYS A 1 161 ? 9.336  17.046 14.275  1.000 21.320 0  161  LYS A C   1 ? 
ATOM   1299 O O   . LYS A 1 161 ? 8.218  16.552 14.437  1.000 22.580 0  161  LYS A O   1 ? 
ATOM   1300 C CB  . LYS A 1 161 ? 10.016 17.272 16.663  1.000 29.000 0  161  LYS A CB  1 ? 
ATOM   1301 C CG  . LYS A 1 161 ? 10.863 16.730 17.781  1.000 35.430 0  161  LYS A CG  1 ? 
ATOM   1302 C CD  . LYS A 1 161 ? 10.397 17.249 19.143  1.000 43.700 0  161  LYS A CD  1 ? 
ATOM   1303 C CE  . LYS A 1 161 ? 11.419 17.022 20.226  1.000 48.290 0  161  LYS A CE  1 ? 
ATOM   1304 N NZ  . LYS A 1 161 ? 12.445 18.071 20.208  1.000 49.630 0  161  LYS A NZ  1 ? 
ATOM   1305 N N   . GLN A 1 162 ? 9.659  17.734 13.186  1.000 18.340 0  162  GLN A N   1 ? 
ATOM   1306 C CA  . GLN A 1 162 ? 8.704  18.037 12.126  1.000 18.680 0  162  GLN A CA  1 ? 
ATOM   1307 C C   . GLN A 1 162 ? 7.464  18.751 12.669  1.000 18.640 0  162  GLN A C   1 ? 
ATOM   1308 O O   . GLN A 1 162 ? 6.347  18.502 12.199  1.000 19.570 0  162  GLN A O   1 ? 
ATOM   1309 C CB  . GLN A 1 162 ? 8.368  16.786 11.320  1.000 21.230 0  162  GLN A CB  1 ? 
ATOM   1310 C CG  . GLN A 1 162 ? 9.593  16.180 10.647  1.000 23.270 0  162  GLN A CG  1 ? 
ATOM   1311 C CD  . GLN A 1 162 ? 9.288  14.935 9.844   1.000 26.320 0  162  GLN A CD  1 ? 
ATOM   1312 O OE1 . GLN A 1 162 ? 8.137  14.618 9.545   1.000 29.150 0  162  GLN A OE1 1 ? 
ATOM   1313 N NE2 . GLN A 1 162 ? 10.329 14.209 9.488   1.000 30.380 0  162  GLN A NE2 1 ? 
ATOM   1314 N N   . LYS A 1 163 ? 7.680  19.659 13.621  1.000 16.830 0  163  LYS A N   1 ? 
ATOM   1315 C CA  . LYS A 1 163 ? 6.627  20.501 14.160  1.000 16.750 0  163  LYS A CA  1 ? 
ATOM   1316 C C   . LYS A 1 163 ? 6.773  21.940 13.664  1.000 16.020 0  163  LYS A C   1 ? 
ATOM   1317 O O   . LYS A 1 163 ? 5.832  22.732 13.790  1.000 14.520 0  163  LYS A O   1 ? 
ATOM   1318 C CB  . LYS A 1 163 ? 6.658  20.553 15.685  1.000 20.160 0  163  LYS A CB  1 ? 
ATOM   1319 C CG  . LYS A 1 163 ? 6.320  19.269 16.406  1.000 23.950 0  163  LYS A CG  1 ? 
ATOM   1320 C CD  . LYS A 1 163 ? 5.011  18.633 15.973  1.000 27.950 0  163  LYS A CD  1 ? 
ATOM   1321 C CE  . LYS A 1 163 ? 4.632  17.553 16.961  1.000 35.120 0  163  LYS A CE  1 ? 
ATOM   1322 N NZ  . LYS A 1 163 ? 3.180  17.424 16.991  1.000 40.140 0  163  LYS A NZ  1 ? 
ATOM   1323 N N   . TRP A 1 164 ? 7.929  22.299 13.071  1.000 13.120 0  164  TRP A N   1 ? 
ATOM   1324 C CA  . TRP A 1 164 ? 8.143  23.636 12.534  1.000 13.140 0  164  TRP A CA  1 ? 
ATOM   1325 C C   . TRP A 1 164 ? 8.657  23.451 11.102  1.000 13.090 0  164  TRP A C   1 ? 
ATOM   1326 O O   . TRP A 1 164 ? 9.663  22.796 10.888  1.000 14.250 0  164  TRP A O   1 ? 
ATOM   1327 C CB  . TRP A 1 164 ? 9.166  24.430 13.369  1.000 13.820 0  164  TRP A CB  1 ? 
ATOM   1328 C CG  . TRP A 1 164 ? 8.665  24.673 14.756  1.000 14.960 0  164  TRP A CG  1 ? 
ATOM   1329 C CD1 . TRP A 1 164 ? 8.761  23.872 15.840  1.000 16.480 0  164  TRP A CD1 1 ? 
ATOM   1330 C CD2 . TRP A 1 164 ? 7.843  25.782 15.132  1.000 15.390 0  164  TRP A CD2 1 ? 
ATOM   1331 N NE1 . TRP A 1 164 ? 8.017  24.397 16.875  1.000 18.080 0  164  TRP A NE1 1 ? 
ATOM   1332 C CE2 . TRP A 1 164 ? 7.481  25.579 16.484  1.000 16.060 0  164  TRP A CE2 1 ? 
ATOM   1333 C CE3 . TRP A 1 164 ? 7.433  26.938 14.465  1.000 16.120 0  164  TRP A CE3 1 ? 
ATOM   1334 C CZ2 . TRP A 1 164 ? 6.686  26.488 17.175  1.000 16.870 0  164  TRP A CZ2 1 ? 
ATOM   1335 C CZ3 . TRP A 1 164 ? 6.735  27.881 15.188  1.000 17.460 0  164  TRP A CZ3 1 ? 
ATOM   1336 C CH2 . TRP A 1 164 ? 6.346  27.639 16.506  1.000 15.300 0  164  TRP A CH2 1 ? 
ATOM   1337 N N   . LEU A 1 165 ? 7.958  24.039 10.147  1.000 13.760 0  165  LEU A N   1 ? 
ATOM   1338 C CA  . LEU A 1 165 ? 8.193  23.788 8.732   1.000 13.220 0  165  LEU A CA  1 ? 
ATOM   1339 C C   . LEU A 1 165 ? 8.517  25.134 8.083   1.000 13.870 0  165  LEU A C   1 ? 
ATOM   1340 O O   . LEU A 1 165 ? 7.942  26.170 8.461   1.000 15.230 0  165  LEU A O   1 ? 
ATOM   1341 C CB  . LEU A 1 165 ? 6.948  23.174 8.101   1.000 13.500 0  165  LEU A CB  1 ? 
ATOM   1342 C CG  . LEU A 1 165 ? 6.286  22.053 8.885   1.000 13.900 0  165  LEU A CG  1 ? 
ATOM   1343 C CD1 . LEU A 1 165 ? 5.085  21.557 8.094   1.000 15.000 0  165  LEU A CD1 1 ? 
ATOM   1344 C CD2 . LEU A 1 165 ? 7.245  20.956 9.168   1.000 14.230 0  165  LEU A CD2 1 ? 
ATOM   1345 N N   . LEU A 1 166 ? 9.429  25.148 7.116   1.000 11.770 0  166  LEU A N   1 ? 
ATOM   1346 C CA  . LEU A 1 166 ? 9.910  26.396 6.559   1.000 12.370 0  166  LEU A CA  1 ? 
ATOM   1347 C C   . LEU A 1 166 ? 10.067 26.239 5.048   1.000 12.620 0  166  LEU A C   1 ? 
ATOM   1348 O O   . LEU A 1 166 ? 10.908 25.469 4.611   1.000 13.180 0  166  LEU A O   1 ? 
ATOM   1349 C CB  . LEU A 1 166 ? 11.234 26.842 7.182   1.000 13.610 0  166  LEU A CB  1 ? 
ATOM   1350 C CG  . LEU A 1 166 ? 11.743 28.179 6.648   1.000 15.640 0  166  LEU A CG  1 ? 
ATOM   1351 C CD1 . LEU A 1 166 ? 10.942 29.269 7.361   1.000 15.790 0  166  LEU A CD1 1 ? 
ATOM   1352 C CD2 . LEU A 1 166 ? 13.208 28.315 6.845   1.000 19.440 0  166  LEU A CD2 1 ? 
ATOM   1353 N N   . LEU A 1 167 ? 9.291  27.018 4.280   1.000 12.220 0  167  LEU A N   1 ? 
ATOM   1354 C CA  . LEU A 1 167 ? 9.361  27.075 2.840   1.000 11.850 0  167  LEU A CA  1 ? 
ATOM   1355 C C   . LEU A 1 167 ? 10.013 28.399 2.448   1.000 13.020 0  167  LEU A C   1 ? 
ATOM   1356 O O   . LEU A 1 167 ? 9.644  29.440 2.978   1.000 14.130 0  167  LEU A O   1 ? 
ATOM   1357 C CB  . LEU A 1 167 ? 7.947  26.990 2.294   1.000 14.270 0  167  LEU A CB  1 ? 
ATOM   1358 C CG  . LEU A 1 167 ? 7.832  26.955 0.774   1.000 14.290 0  167  LEU A CG  1 ? 
ATOM   1359 C CD1 . LEU A 1 167 ? 8.484  25.702 0.189   1.000 14.290 0  167  LEU A CD1 1 ? 
ATOM   1360 C CD2 . LEU A 1 167 ? 6.347  27.022 0.375   1.000 16.280 0  167  LEU A CD2 1 ? 
ATOM   1361 N N   . THR A 1 168 ? 10.963 28.350 1.510   1.000 12.190 0  168  THR A N   1 ? 
ATOM   1362 C CA  . THR A 1 168 ? 11.717 29.520 1.084   1.000 14.450 0  168  THR A CA  1 ? 
ATOM   1363 C C   . THR A 1 168 ? 11.662 29.701 -0.424  1.000 14.320 0  168  THR A C   1 ? 
ATOM   1364 O O   . THR A 1 168 ? 11.975 28.778 -1.180  1.000 12.690 0  168  THR A O   1 ? 
ATOM   1365 C CB  . THR A 1 168 ? 13.188 29.455 1.487   1.000 15.430 0  168  THR A CB  1 ? 
ATOM   1366 O OG1 . THR A 1 168 ? 13.268 29.278 2.899   1.000 16.940 0  168  THR A OG1 1 ? 
ATOM   1367 C CG2 . THR A 1 168 ? 13.932 30.741 1.100   1.000 16.390 0  168  THR A CG2 1 ? 
ATOM   1368 N N   . GLY A 1 169 ? 11.277 30.922 -0.846  1.000 13.640 0  169  GLY A N   1 ? 
ATOM   1369 C CA  . GLY A 1 169 ? 11.354 31.290 -2.247  1.000 14.650 0  169  GLY A CA  1 ? 
ATOM   1370 C C   . GLY A 1 169 ? 12.082 32.614 -2.442  1.000 16.660 0  169  GLY A C   1 ? 
ATOM   1371 O O   . GLY A 1 169 ? 12.251 33.376 -1.488  1.000 17.180 0  169  GLY A O   1 ? 
ATOM   1372 N N   . ILE A 1 170 ? 12.465 32.885 -3.695  1.000 16.180 0  170  ILE A N   1 ? 
ATOM   1373 C CA  . ILE A 1 170 ? 13.085 34.135 -4.058  1.000 15.450 0  170  ILE A CA  1 ? 
ATOM   1374 C C   . ILE A 1 170 ? 12.431 34.688 -5.321  1.000 16.630 0  170  ILE A C   1 ? 
ATOM   1375 O O   . ILE A 1 170 ? 11.832 33.986 -6.155  1.000 16.170 0  170  ILE A O   1 ? 
ATOM   1376 C CB  . ILE A 1 170 ? 14.608 34.002 -4.211  1.000 15.430 0  170  ILE A CB  1 ? 
ATOM   1377 C CG1 . ILE A 1 170 ? 14.967 32.964 -5.294  1.000 16.730 0  170  ILE A CG1 1 ? 
ATOM   1378 C CG2 . ILE A 1 170 ? 15.287 33.656 -2.881  1.000 15.780 0  170  ILE A CG2 1 ? 
ATOM   1379 C CD1 . ILE A 1 170 ? 16.459 32.805 -5.516  1.000 17.910 0  170  ILE A CD1 1 ? 
ATOM   1380 N N   . SER A 1 171 ? 12.623 35.993 -5.484  1.000 16.240 0  171  SER A N   1 ? 
ATOM   1381 C CA  . SER A 1 171 ? 12.178 36.708 -6.675  1.000 17.840 0  171  SER A CA  1 ? 
ATOM   1382 C C   . SER A 1 171 ? 12.959 38.011 -6.752  1.000 19.470 0  171  SER A C   1 ? 
ATOM   1383 O O   . SER A 1 171 ? 13.613 38.378 -5.775  1.000 20.110 0  171  SER A O   1 ? 
ATOM   1384 C CB  . SER A 1 171 ? 10.708 36.949 -6.686  1.000 19.330 0  171  SER A CB  1 ? 
ATOM   1385 O OG  . SER A 1 171 ? 10.360 37.953 -5.755  1.000 21.000 0  171  SER A OG  1 ? 
ATOM   1386 N N   . ALA A 1 172 ? 12.878 38.695 -7.914  1.000 18.750 0  172  ALA A N   1 ? 
ATOM   1387 C CA  . ALA A 1 172 ? 13.537 39.977 -8.088  1.000 20.940 0  172  ALA A CA  1 ? 
ATOM   1388 C C   . ALA A 1 172 ? 12.542 41.090 -7.787  1.000 21.690 0  172  ALA A C   1 ? 
ATOM   1389 O O   . ALA A 1 172 ? 11.444 41.087 -8.324  1.000 24.970 0  172  ALA A O   1 ? 
ATOM   1390 C CB  . ALA A 1 172 ? 14.039 40.126 -9.486  1.000 22.000 0  172  ALA A CB  1 ? 
ATOM   1391 N N   . GLN A 1 173 ? 12.905 41.978 -6.876  1.000 23.110 0  173  GLN A N   1 ? 
ATOM   1392 C CA  . GLN A 1 173 ? 12.064 43.116 -6.520  1.000 25.220 0  173  GLN A CA  1 ? 
ATOM   1393 C C   . GLN A 1 173 ? 12.984 44.329 -6.379  1.000 25.360 0  173  GLN A C   1 ? 
ATOM   1394 O O   . GLN A 1 173 ? 13.965 44.283 -5.644  1.000 24.090 0  173  GLN A O   1 ? 
ATOM   1395 C CB  . GLN A 1 173 ? 11.253 42.918 -5.234  1.000 26.040 0  173  GLN A CB  1 ? 
ATOM   1396 C CG  . GLN A 1 173 ? 10.462 41.615 -5.144  1.000 32.200 0  173  GLN A CG  1 ? 
ATOM   1397 C CD  . GLN A 1 173 ? 9.321  41.511 -6.140  1.000 42.130 0  173  GLN A CD  1 ? 
ATOM   1398 O OE1 . GLN A 1 173 ? 8.847  42.516 -6.685  1.000 60.500 0  173  GLN A OE1 1 ? 
ATOM   1399 N NE2 . GLN A 1 173 ? 8.840  40.294 -6.381  1.000 44.390 0  173  GLN A NE2 1 ? 
ATOM   1400 N N   . GLN A 1 174 ? 12.692 45.384 -7.141  1.000 30.440 0  174  GLN A N   1 ? 
ATOM   1401 C CA  . GLN A 1 174 ? 13.467 46.619 -7.123  1.000 34.330 0  174  GLN A CA  1 ? 
ATOM   1402 C C   . GLN A 1 174 ? 14.934 46.307 -7.376  1.000 29.790 0  174  GLN A C   1 ? 
ATOM   1403 O O   . GLN A 1 174 ? 15.808 46.793 -6.662  1.000 34.590 0  174  GLN A O   1 ? 
ATOM   1404 C CB  . GLN A 1 174 ? 13.232 47.348 -5.799  1.000 42.600 0  174  GLN A CB  1 ? 
ATOM   1405 C CG  . GLN A 1 174 ? 11.754 47.414 -5.417  1.000 53.940 0  174  GLN A CG  1 ? 
ATOM   1406 C CD  . GLN A 1 174 ? 11.487 48.326 -4.241  1.000 66.550 0  174  GLN A CD  1 ? 
ATOM   1407 O OE1 . GLN A 1 174 ? 11.661 47.944 -3.076  1.000 72.270 0  174  GLN A OE1 1 ? 
ATOM   1408 N NE2 . GLN A 1 174 ? 11.039 49.540 -4.538  1.000 73.640 0  174  GLN A NE2 1 ? 
ATOM   1409 N N   . ASN A 1 175 ? 15.168 45.447 -8.363  1.000 27.930 0  175  ASN A N   1 ? 
ATOM   1410 C CA  . ASN A 1 175 ? 16.509 45.068 -8.777  1.000 26.180 0  175  ASN A CA  1 ? 
ATOM   1411 C C   . ASN A 1 175 ? 17.313 44.412 -7.653  1.000 24.740 0  175  ASN A C   1 ? 
ATOM   1412 O O   . ASN A 1 175 ? 18.537 44.484 -7.641  1.000 23.700 0  175  ASN A O   1 ? 
ATOM   1413 C CB  . ASN A 1 175 ? 17.286 46.251 -9.335  1.000 29.800 0  175  ASN A CB  1 ? 
ATOM   1414 C CG  . ASN A 1 175 ? 18.366 45.794 -10.279 1.000 33.940 0  175  ASN A CG  1 ? 
ATOM   1415 O OD1 . ASN A 1 175 ? 18.067 45.055 -11.217 1.000 42.570 0  175  ASN A OD1 1 ? 
ATOM   1416 N ND2 . ASN A 1 175 ? 19.616 46.142 -10.024 1.000 41.530 0  175  ASN A ND2 1 ? 
ATOM   1417 N N   . ARG A 1 176 ? 16.665 43.676 -6.732  1.000 22.300 0  176  ARG A N   1 ? 
ATOM   1418 C CA  . ARG A 1 176 ? 17.468 42.841 -5.858  1.000 20.670 0  176  ARG A CA  1 ? 
ATOM   1419 C C   . ARG A 1 176 ? 16.744 41.518 -5.664  1.000 20.730 0  176  ARG A C   1 ? 
ATOM   1420 O O   . ARG A 1 176 ? 15.562 41.411 -5.979  1.000 20.750 0  176  ARG A O   1 ? 
ATOM   1421 C CB  . ARG A 1 176 ? 17.859 43.461 -4.506  1.000 24.810 0  176  ARG A CB  1 ? 
ATOM   1422 C CG  . ARG A 1 176 ? 16.714 43.679 -3.546  1.000 27.880 0  176  ARG A CG  1 ? 
ATOM   1423 C CD  . ARG A 1 176 ? 17.123 44.432 -2.263  1.000 28.960 0  176  ARG A CD  1 ? 
ATOM   1424 N NE  . ARG A 1 176 ? 15.976 44.387 -1.350  1.000 28.150 0  176  ARG A NE  1 ? 
ATOM   1425 C CZ  . ARG A 1 176 ? 15.881 43.530 -0.336  1.000 31.460 0  176  ARG A CZ  1 ? 
ATOM   1426 N NH1 . ARG A 1 176 ? 16.825 42.612 -0.167  1.000 33.820 0  176  ARG A NH1 1 ? 
ATOM   1427 N NH2 . ARG A 1 176 ? 14.853 43.578 0.484   1.000 32.130 0  176  ARG A NH2 1 ? 
ATOM   1428 N N   . VAL A 1 177 ? 17.499 40.531 -5.192  1.000 20.030 0  177  VAL A N   1 ? 
ATOM   1429 C CA  . VAL A 1 177 ? 16.936 39.204 -4.985  1.000 18.330 0  177  VAL A CA  1 ? 
ATOM   1430 C C   . VAL A 1 177 ? 16.372 39.201 -3.569  1.000 15.960 0  177  VAL A C   1 ? 
ATOM   1431 O O   . VAL A 1 177 ? 17.118 39.285 -2.591  1.000 17.060 0  177  VAL A O   1 ? 
ATOM   1432 C CB  . VAL A 1 177 ? 17.950 38.058 -5.158  1.000 18.440 0  177  VAL A CB  1 ? 
ATOM   1433 C CG1 . VAL A 1 177 ? 17.327 36.720 -4.781  1.000 17.870 0  177  VAL A CG1 1 ? 
ATOM   1434 C CG2 . VAL A 1 177 ? 18.565 37.993 -6.550  1.000 19.480 0  177  VAL A CG2 1 ? 
ATOM   1435 N N   . VAL A 1 178 ? 15.049 39.096 -3.476  1.000 15.940 0  178  VAL A N   1 ? 
ATOM   1436 C CA  . VAL A 1 178 ? 14.375 39.166 -2.205  1.000 16.640 0  178  VAL A CA  1 ? 
ATOM   1437 C C   . VAL A 1 178 ? 13.926 37.760 -1.819  1.000 17.650 0  178  VAL A C   1 ? 
ATOM   1438 O O   . VAL A 1 178 ? 13.249 37.056 -2.582  1.000 17.650 0  178  VAL A O   1 ? 
ATOM   1439 C CB  . VAL A 1 178 ? 13.176 40.133 -2.278  1.000 19.330 0  178  VAL A CB  1 ? 
ATOM   1440 C CG1 . VAL A 1 178 ? 12.402 40.170 -0.961  1.000 20.130 0  178  VAL A CG1 1 ? 
ATOM   1441 C CG2 . VAL A 1 178 ? 13.634 41.531 -2.642  1.000 22.350 0  178  VAL A CG2 1 ? 
ATOM   1442 N N   . GLY A 1 179 ? 14.205 37.426 -0.572  1.000 16.910 0  179  GLY A N   1 ? 
ATOM   1443 C CA  . GLY A 1 179 ? 13.810 36.125 -0.060  1.000 16.680 0  179  GLY A CA  1 ? 
ATOM   1444 C C   . GLY A 1 179 ? 12.485 36.234 0.686   1.000 17.010 0  179  GLY A C   1 ? 
ATOM   1445 O O   . GLY A 1 179 ? 12.289 37.168 1.457   1.000 16.840 0  179  GLY A O   1 ? 
ATOM   1446 N N   . ALA A 1 180 ? 11.601 35.271 0.425   1.000 16.850 0  180  ALA A N   1 ? 
ATOM   1447 C CA  . ALA A 1 180 ? 10.335 35.150 1.135   1.000 17.990 0  180  ALA A CA  1 ? 
ATOM   1448 C C   . ALA A 1 180 ? 10.220 33.762 1.749   1.000 15.840 0  180  ALA A C   1 ? 
ATOM   1449 O O   . ALA A 1 180 ? 10.262 32.758 1.064   1.000 15.830 0  180  ALA A O   1 ? 
ATOM   1450 C CB  . ALA A 1 180 ? 9.170  35.438 0.222   1.000 18.420 0  180  ALA A CB  1 ? 
ATOM   1451 N N   . MET A 1 181 ? 10.015 33.726 3.062   1.000 14.520 0  181  MET A N   1 ? 
ATOM   1452 C CA  . MET A 1 181 ? 9.898  32.490 3.786   1.000 12.720 0  181  MET A CA  1 ? 
ATOM   1453 C C   . MET A 1 181 ? 8.503  32.397 4.373   1.000 14.020 0  181  MET A C   1 ? 
ATOM   1454 O O   . MET A 1 181 ? 7.918  33.408 4.749   1.000 14.210 0  181  MET A O   1 ? 
ATOM   1455 C CB  . MET A 1 181 ? 10.893 32.407 4.941   1.000 15.190 0  181  MET A CB  1 ? 
ATOM   1456 C CG  . MET A 1 181 ? 12.324 32.386 4.465   1.000 16.550 0  181  MET A CG  1 ? 
ATOM   1457 S SD  . MET A 1 181 ? 13.515 32.285 5.802   1.000 17.430 0  181  MET A SD  1 ? 
ATOM   1458 C CE  . MET A 1 181 ? 14.984 31.781 4.880   1.000 21.770 0  181  MET A CE  1 ? 
ATOM   1459 N N   . GLN A 1 182 ? 8.058  31.161 4.516   1.000 13.890 0  182  GLN A N   1 ? 
ATOM   1460 C CA  . GLN A 1 182 ? 6.847  30.841 5.248   1.000 12.870 0  182  GLN A CA  1 ? 
ATOM   1461 C C   . GLN A 1 182 ? 7.211  29.842 6.326   1.000 12.580 0  182  GLN A C   1 ? 
ATOM   1462 O O   . GLN A 1 182 ? 7.654  28.728 6.027   1.000 12.790 0  182  GLN A O   1 ? 
ATOM   1463 C CB  . GLN A 1 182 ? 5.831  30.253 4.285   1.000 12.990 0  182  GLN A CB  1 ? 
ATOM   1464 C CG  . GLN A 1 182 ? 4.569  29.772 4.977   1.000 13.980 0  182  GLN A CG  1 ? 
ATOM   1465 C CD  . GLN A 1 182 ? 3.483  29.408 3.994   1.000 15.420 0  182  GLN A CD  1 ? 
ATOM   1466 O OE1 . GLN A 1 182 ? 3.703  29.308 2.782   1.000 15.270 0  182  GLN A OE1 1 ? 
ATOM   1467 N NE2 . GLN A 1 182 ? 2.317  29.109 4.546   1.000 17.060 0  182  GLN A NE2 1 ? 
ATOM   1468 N N   . LEU A 1 183 ? 7.103  30.308 7.575   1.000 13.610 0  183  LEU A N   1 ? 
ATOM   1469 C CA  . LEU A 1 183 ? 7.269  29.476 8.726   1.000 13.490 0  183  LEU A CA  1 ? 
ATOM   1470 C C   . LEU A 1 183 ? 5.887  29.015 9.174   1.000 15.090 0  183  LEU A C   1 ? 
ATOM   1471 O O   . LEU A 1 183 ? 4.992  29.827 9.349   1.000 14.340 0  183  LEU A O   1 ? 
ATOM   1472 C CB  . LEU A 1 183 ? 7.947  30.238 9.856   1.000 12.940 0  183  LEU A CB  1 ? 
ATOM   1473 C CG  . LEU A 1 183 ? 8.160  29.485 11.166  1.000 13.130 0  183  LEU A CG  1 ? 
ATOM   1474 C CD1 . LEU A 1 183 ? 9.180  28.381 10.962  1.000 14.200 0  183  LEU A CD1 1 ? 
ATOM   1475 C CD2 . LEU A 1 183 ? 8.599  30.457 12.243  1.000 14.870 0  183  LEU A CD2 1 ? 
ATOM   1476 N N   . TYR A 1 184 ? 5.780  27.725 9.386   1.000 13.290 0  184  TYR A N   1 ? 
ATOM   1477 C CA  . TYR A 1 184 ? 4.546  27.086 9.796   1.000 14.340 0  184  TYR A CA  1 ? 
ATOM   1478 C C   . TYR A 1 184 ? 4.742  26.256 11.037  1.000 13.500 0  184  TYR A C   1 ? 
ATOM   1479 O O   . TYR A 1 184 ? 5.619  25.393 11.138  1.000 13.480 0  184  TYR A O   1 ? 
ATOM   1480 C CB  . TYR A 1 184 ? 4.002  26.242 8.650   1.000 14.010 0  184  TYR A CB  1 ? 
ATOM   1481 C CG  . TYR A 1 184 ? 2.689  25.521 8.964   1.000 15.220 0  184  TYR A CG  1 ? 
ATOM   1482 C CD1 . TYR A 1 184 ? 1.476  26.222 8.916   1.000 16.390 0  184  TYR A CD1 1 ? 
ATOM   1483 C CD2 . TYR A 1 184 ? 2.656  24.189 9.353   1.000 15.780 0  184  TYR A CD2 1 ? 
ATOM   1484 C CE1 . TYR A 1 184 ? 0.272  25.599 9.186   1.000 16.470 0  184  TYR A CE1 1 ? 
ATOM   1485 C CE2 . TYR A 1 184 ? 1.443  23.536 9.589   1.000 17.890 0  184  TYR A CE2 1 ? 
ATOM   1486 C CZ  . TYR A 1 184 ? 0.257  24.257 9.530   1.000 18.090 0  184  TYR A CZ  1 ? 
ATOM   1487 O OH  . TYR A 1 184 ? -0.943 23.623 9.799   1.000 19.310 0  184  TYR A OH  1 ? 
ATOM   1488 N N   . SER A 1 185 ? 3.789  26.460 11.982  1.000 12.940 0  185  SER A N   1 ? 
ATOM   1489 C CA  . SER A 1 185 ? 3.712  25.700 13.211  1.000 14.380 0  185  SER A CA  1 ? 
ATOM   1490 C C   . SER A 1 185 ? 2.654  24.614 13.074  1.000 15.310 0  185  SER A C   1 ? 
ATOM   1491 O O   . SER A 1 185 ? 1.468  24.937 12.897  1.000 16.610 0  185  SER A O   1 ? 
ATOM   1492 C CB  . SER A 1 185 ? 3.383  26.633 14.369  1.000 17.620 0  185  SER A CB  1 ? 
ATOM   1493 O OG  . SER A 1 185 ? 3.046  25.892 15.534  1.000 15.320 0  185  SER A OG  1 ? 
ATOM   1494 N N   . VAL A 1 186 ? 3.097  23.354 13.169  1.000 15.290 0  186  VAL A N   1 ? 
ATOM   1495 C CA  . VAL A 1 186 ? 2.224  22.199 13.076  1.000 17.270 0  186  VAL A CA  1 ? 
ATOM   1496 C C   . VAL A 1 186 ? 1.260  22.222 14.261  1.000 18.980 0  186  VAL A C   1 ? 
ATOM   1497 O O   . VAL A 1 186 ? 0.075  21.946 14.071  1.000 20.170 0  186  VAL A O   1 ? 
ATOM   1498 C CB  . VAL A 1 186 ? 2.994  20.873 12.944  1.000 19.290 0  186  VAL A CB  1 ? 
ATOM   1499 C CG1 . VAL A 1 186 ? 2.108  19.651 13.126  1.000 22.290 0  186  VAL A CG1 1 ? 
ATOM   1500 C CG2 . VAL A 1 186 ? 3.692  20.790 11.587  1.000 18.230 0  186  VAL A CG2 1 ? 
ATOM   1501 N N   . ASP A 1 187 ? 1.741  22.616 15.432  1.000 20.640 0  187  ASP A N   1 ? 
ATOM   1502 C CA  . ASP A 1 187 ? 0.900  22.495 16.627  1.000 23.370 0  187  ASP A CA  1 ? 
ATOM   1503 C C   . ASP A 1 187 ? -0.158 23.594 16.657  1.000 25.440 0  187  ASP A C   1 ? 
ATOM   1504 O O   . ASP A 1 187 ? -1.273 23.383 17.177  1.000 25.570 0  187  ASP A O   1 ? 
ATOM   1505 C CB  . ASP A 1 187 ? 1.753  22.421 17.880  1.000 26.110 0  187  ASP A CB  1 ? 
ATOM   1506 C CG  . ASP A 1 187 ? 2.432  21.068 18.082  1.000 27.030 0  187  ASP A CG  1 ? 
ATOM   1507 O OD1 . ASP A 1 187 ? 1.939  20.043 17.521  1.000 32.840 0  187  ASP A OD1 1 ? 
ATOM   1508 O OD2 . ASP A 1 187 ? 3.491  21.083 18.716  1.000 31.320 0  187  ASP A OD2 1 ? 
ATOM   1509 N N   . ARG A 1 188 ? 0.180  24.772 16.132  1.000 20.560 0  188  ARG A N   1 ? 
ATOM   1510 C CA  . ARG A 1 188 ? -0.744 25.904 16.123  1.000 21.520 0  188  ARG A CA  1 ? 
ATOM   1511 C C   . ARG A 1 188 ? -1.560 25.990 14.837  1.000 24.820 0  188  ARG A C   1 ? 
ATOM   1512 O O   . ARG A 1 188 ? -2.626 26.617 14.802  1.000 20.860 0  188  ARG A O   1 ? 
ATOM   1513 C CB  . ARG A 1 188 ? -0.089 27.275 16.264  1.000 24.670 0  188  ARG A CB  1 ? 
ATOM   1514 C CG  . ARG A 1 188 ? 0.524  27.585 17.610  1.000 29.250 0  188  ARG A CG  1 ? 
ATOM   1515 C CD  . ARG A 1 188 ? 0.972  29.027 17.783  1.000 29.360 0  188  ARG A CD  1 ? 
ATOM   1516 N NE  . ARG A 1 188 ? -0.003 30.086 17.512  1.000 32.320 0  188  ARG A NE  1 ? 
ATOM   1517 C CZ  . ARG A 1 188 ? 0.328  31.379 17.499  1.000 31.650 0  188  ARG A CZ  1 ? 
ATOM   1518 N NH1 . ARG A 1 188 ? 1.556  31.749 17.797  1.000 30.550 0  188  ARG A NH1 1 ? 
ATOM   1519 N NH2 . ARG A 1 188 ? -0.578 32.285 17.196  1.000 37.570 0  188  ARG A NH2 1 ? 
ATOM   1520 N N   . LYS A 1 189 ? -1.044 25.401 13.751  1.000 21.750 0  189  LYS A N   1 ? 
ATOM   1521 C CA  . LYS A 1 189 ? -1.663 25.499 12.443  1.000 22.460 0  189  LYS A CA  1 ? 
ATOM   1522 C C   . LYS A 1 189 ? -1.743 26.956 12.006  1.000 22.060 0  189  LYS A C   1 ? 
ATOM   1523 O O   . LYS A 1 189 ? -2.746 27.385 11.442  1.000 23.850 0  189  LYS A O   1 ? 
ATOM   1524 C CB  . LYS A 1 189 ? -3.028 24.793 12.363  1.000 28.080 0  189  LYS A CB  1 ? 
ATOM   1525 C CG  . LYS A 1 189 ? -2.949 23.292 12.616  1.000 34.510 0  189  LYS A CG  1 ? 
ATOM   1526 C CD  . LYS A 1 189 ? -4.161 22.735 13.351  1.000 48.780 0  189  LYS A CD  1 ? 
ATOM   1527 C CE  . LYS A 1 189 ? -4.114 23.128 14.827  1.000 56.330 0  189  LYS A CE  1 ? 
ATOM   1528 N NZ  . LYS A 1 189 ? -5.365 22.913 15.572  1.000 55.970 0  189  LYS A NZ  1 ? 
ATOM   1529 N N   . VAL A 1 190 ? -0.631 27.684 12.147  1.000 17.830 0  190  VAL A N   1 ? 
ATOM   1530 C CA  . VAL A 1 190 ? -0.540 29.073 11.770  1.000 17.620 0  190  VAL A CA  1 ? 
ATOM   1531 C C   . VAL A 1 190 ? 0.780  29.255 11.010  1.000 17.190 0  190  VAL A C   1 ? 
ATOM   1532 O O   . VAL A 1 190 ? 1.745  28.536 11.347  1.000 16.790 0  190  VAL A O   1 ? 
ATOM   1533 C CB  . VAL A 1 190 ? -0.617 29.859 13.094  1.000 23.130 0  190  VAL A CB  1 ? 
ATOM   1534 C CG1 . VAL A 1 190 ? 0.138  31.178 13.093  1.000 25.630 0  190  VAL A CG1 1 ? 
ATOM   1535 C CG2 . VAL A 1 190 ? -2.099 30.086 13.470  1.000 26.190 0  190  VAL A CG2 1 ? 
ATOM   1536 N N   . SER A 1 191 ? 0.743  30.145 10.020  1.000 16.910 0  191  SER A N   1 ? 
ATOM   1537 C CA  . SER A 1 191 ? 1.943  30.550 9.276   1.000 16.350 0  191  SER A CA  1 ? 
ATOM   1538 C C   . SER A 1 191 ? 2.369  31.954 9.653   1.000 18.840 0  191  SER A C   1 ? 
ATOM   1539 O O   . SER A 1 191 ? 1.574  32.806 10.076  1.000 20.450 0  191  SER A O   1 ? 
ATOM   1540 C CB  . SER A 1 191 ? 1.735  30.494 7.792   1.000 17.110 0  191  SER A CB  1 ? 
ATOM   1541 O OG  . SER A 1 191 ? 1.470  29.196 7.324   1.000 17.200 0  191  SER A OG  1 ? 
ATOM   1542 N N   . GLN A 1 192 ? 3.655  32.233 9.469   1.000 16.800 0  192  GLN A N   1 ? 
ATOM   1543 C CA  . GLN A 1 192 ? 4.158  33.590 9.559   1.000 16.720 0  192  GLN A CA  1 ? 
ATOM   1544 C C   . GLN A 1 192 ? 5.068  33.838 8.358   1.000 15.840 0  192  GLN A C   1 ? 
ATOM   1545 O O   . GLN A 1 192 ? 6.015  33.067 8.148   1.000 15.370 0  192  GLN A O   1 ? 
ATOM   1546 C CB  . GLN A 1 192 ? 4.942  33.780 10.848  1.000 16.710 0  192  GLN A CB  1 ? 
ATOM   1547 C CG  . GLN A 1 192 ? 5.484  35.185 11.024  1.000 18.970 0  192  GLN A CG  1 ? 
ATOM   1548 C CD  . GLN A 1 192 ? 6.166  35.416 12.359  1.000 16.580 0  192  GLN A CD  1 ? 
ATOM   1549 O OE1 . GLN A 1 192 ? 6.002  34.667 13.299  1.000 20.170 0  192  GLN A OE1 1 ? 
ATOM   1550 N NE2 . GLN A 1 192 ? 6.972  36.470 12.457  1.000 21.350 0  192  GLN A NE2 1 ? 
ATOM   1551 N N   . PRO A 1 193 ? 4.824  34.905 7.580   1.000 16.370 0  193  PRO A N   1 ? 
ATOM   1552 C CA  . PRO A 1 193 ? 5.690  35.287 6.480   1.000 16.860 0  193  PRO A CA  1 ? 
ATOM   1553 C C   . PRO A 1 193 ? 6.887  36.027 7.042   1.000 17.340 0  193  PRO A C   1 ? 
ATOM   1554 O O   . PRO A 1 193 ? 6.749  36.911 7.894   1.000 17.980 0  193  PRO A O   1 ? 
ATOM   1555 C CB  . PRO A 1 193 ? 4.818  36.202 5.598   1.000 19.620 0  193  PRO A CB  1 ? 
ATOM   1556 C CG  . PRO A 1 193 ? 3.824  36.855 6.593   1.000 19.930 0  193  PRO A CG  1 ? 
ATOM   1557 C CD  . PRO A 1 193 ? 3.671  35.845 7.730   1.000 18.920 0  193  PRO A CD  1 ? 
ATOM   1558 N N   . ILE A 1 194 ? 8.087  35.651 6.584   1.000 17.890 0  194  ILE A N   1 ? 
ATOM   1559 C CA  . ILE A 1 194 ? 9.309  36.290 7.064   1.000 17.710 0  194  ILE A CA  1 ? 
ATOM   1560 C C   . ILE A 1 194 ? 10.188 36.577 5.849   1.000 17.370 0  194  ILE A C   1 ? 
ATOM   1561 O O   . ILE A 1 194 ? 10.298 35.716 4.971   1.000 15.810 0  194  ILE A O   1 ? 
ATOM   1562 C CB  . ILE A 1 194 ? 10.026 35.337 8.035   1.000 18.660 0  194  ILE A CB  1 ? 
ATOM   1563 C CG1 . ILE A 1 194 ? 9.120  34.999 9.217   1.000 20.980 0  194  ILE A CG1 1 ? 
ATOM   1564 C CG2 . ILE A 1 194 ? 11.387 35.876 8.476   1.000 19.520 0  194  ILE A CG2 1 ? 
ATOM   1565 C CD1 . ILE A 1 194 ? 9.609  33.831 10.042  1.000 19.770 0  194  ILE A CD1 1 ? 
ATOM   1566 N N   . GLU A 1 195 ? 10.812 37.763 5.817   1.000 15.750 0  195  GLU A N   1 ? 
ATOM   1567 C CA  . GLU A 1 195 ? 11.808 38.012 4.781   1.000 16.630 0  195  GLU A CA  1 ? 
ATOM   1568 C C   . GLU A 1 195 ? 13.089 37.282 5.185   1.000 14.610 0  195  GLU A C   1 ? 
ATOM   1569 O O   . GLU A 1 195 ? 13.705 37.601 6.214   1.000 16.070 0  195  GLU A O   1 ? 
ATOM   1570 C CB  . GLU A 1 195 ? 11.990 39.520 4.581   1.000 18.350 0  195  GLU A CB  1 ? 
ATOM   1571 C CG  . GLU A 1 195 ? 12.946 39.809 3.424   1.000 19.540 0  195  GLU A CG  1 ? 
ATOM   1572 C CD  . GLU A 1 195 ? 13.450 41.239 3.247   1.000 26.910 0  195  GLU A CD  1 ? 
ATOM   1573 O OE1 . GLU A 1 195 ? 13.051 42.109 4.072   1.000 30.720 0  195  GLU A OE1 1 ? 
ATOM   1574 O OE2 . GLU A 1 195 ? 14.213 41.484 2.267   1.000 22.390 0  195  GLU A OE2 1 ? 
ATOM   1575 N N   . GLY A 1 196 ? 13.574 36.378 4.316   1.000 14.630 0  196  GLY A N   1 ? 
ATOM   1576 C CA  . GLY A 1 196 ? 14.786 35.641 4.609   1.000 13.980 0  196  GLY A CA  1 ? 
ATOM   1577 C C   . GLY A 1 196 ? 15.271 34.890 3.383   1.000 13.280 0  196  GLY A C   1 ? 
ATOM   1578 O O   . GLY A 1 196 ? 14.485 34.545 2.521   1.000 13.970 0  196  GLY A O   1 ? 
ATOM   1579 N N   . HIS A 1 197 ? 16.568 34.626 3.347   1.000 15.430 0  197  HIS A N   1 ? 
ATOM   1580 C CA  . HIS A 1 197 ? 17.207 34.001 2.196   1.000 14.630 0  197  HIS A CA  1 ? 
ATOM   1581 C C   . HIS A 1 197 ? 17.650 32.560 2.445   1.000 14.490 0  197  HIS A C   1 ? 
ATOM   1582 O O   . HIS A 1 197 ? 17.682 31.767 1.501   1.000 16.040 0  197  HIS A O   1 ? 
ATOM   1583 C CB  . HIS A 1 197 ? 18.437 34.834 1.814   1.000 16.830 0  197  HIS A CB  1 ? 
ATOM   1584 C CG  . HIS A 1 197 ? 18.169 36.028 0.992   1.000 17.010 0  197  HIS A CG  1 ? 
ATOM   1585 N ND1 . HIS A 1 197 ? 18.404 37.322 1.415   1.000 18.530 0  197  HIS A ND1 1 ? 
ATOM   1586 C CD2 . HIS A 1 197 ? 17.670 36.112 -0.257  1.000 17.520 0  197  HIS A CD2 1 ? 
ATOM   1587 C CE1 . HIS A 1 197 ? 18.114 38.152 0.421   1.000 17.430 0  197  HIS A CE1 1 ? 
ATOM   1588 N NE2 . HIS A 1 197 ? 17.664 37.460 -0.616  1.000 17.090 0  197  HIS A NE2 1 ? 
ATOM   1589 N N   . ALA A 1 198 ? 18.147 32.239 3.644   1.000 14.570 0  198  ALA A N   1 ? 
ATOM   1590 C CA  . ALA A 1 198 ? 18.615 30.886 3.939   1.000 14.750 0  198  ALA A CA  1 ? 
ATOM   1591 C C   . ALA A 1 198 ? 18.406 30.629 5.423   1.000 14.690 0  198  ALA A C   1 ? 
ATOM   1592 O O   . ALA A 1 198 ? 18.509 31.553 6.229   1.000 15.000 0  198  ALA A O   1 ? 
ATOM   1593 C CB  . ALA A 1 198 ? 20.095 30.691 3.576   1.000 15.150 0  198  ALA A CB  1 ? 
ATOM   1594 N N   . ALA A 1 199 ? 18.132 29.380 5.771   1.000 14.710 0  199  ALA A N   1 ? 
ATOM   1595 C CA  . ALA A 1 199 ? 17.820 29.030 7.149   1.000 15.780 0  199  ALA A CA  1 ? 
ATOM   1596 C C   . ALA A 1 199 ? 18.058 27.563 7.444   1.000 14.800 0  199  ALA A C   1 ? 
ATOM   1597 O O   . ALA A 1 199 ? 18.297 26.732 6.558   1.000 15.500 0  199  ALA A O   1 ? 
ATOM   1598 C CB  . ALA A 1 199 ? 16.377 29.356 7.399   1.000 17.700 0  199  ALA A CB  1 ? 
ATOM   1599 N N   . SER A 1 200 ? 18.026 27.278 8.750   1.000 14.580 0  200  SER A N   1 ? 
ATOM   1600 C CA  . SER A 1 200 ? 18.144 25.950 9.281   1.000 13.960 0  200  SER A CA  1 ? 
ATOM   1601 C C   . SER A 1 200 ? 17.524 25.946 10.668  1.000 14.790 0  200  SER A C   1 ? 
ATOM   1602 O O   . SER A 1 200 ? 17.456 26.996 11.287  1.000 16.580 0  200  SER A O   1 ? 
ATOM   1603 C CB  . SER A 1 200 ? 19.545 25.510 9.319   1.000 15.850 0  200  SER A CB  1 ? 
ATOM   1604 O OG  . SER A 1 200 ? 19.597 24.156 9.702   1.000 17.480 0  200  SER A OG  1 ? 
ATOM   1605 N N   . PHE A 1 201 ? 17.009 24.790 11.105  1.000 15.460 0  201  PHE A N   1 ? 
ATOM   1606 C CA  . PHE A 1 201 ? 16.682 24.572 12.497  1.000 13.420 0  201  PHE A CA  1 ? 
ATOM   1607 C C   . PHE A 1 201 ? 17.873 23.918 13.162  1.000 14.910 0  201  PHE A C   1 ? 
ATOM   1608 O O   . PHE A 1 201 ? 18.680 23.326 12.486  1.000 16.680 0  201  PHE A O   1 ? 
ATOM   1609 C CB  . PHE A 1 201 ? 15.423 23.699 12.583  1.000 13.630 0  201  PHE A CB  1 ? 
ATOM   1610 C CG  . PHE A 1 201 ? 14.202 24.445 12.070  1.000 12.750 0  201  PHE A CG  1 ? 
ATOM   1611 C CD1 . PHE A 1 201 ? 13.458 25.258 12.897  1.000 13.880 0  201  PHE A CD1 1 ? 
ATOM   1612 C CD2 . PHE A 1 201 ? 13.793 24.316 10.744  1.000 14.180 0  201  PHE A CD2 1 ? 
ATOM   1613 C CE1 . PHE A 1 201 ? 12.364 25.953 12.404  1.000 15.160 0  201  PHE A CE1 1 ? 
ATOM   1614 C CE2 . PHE A 1 201 ? 12.678 24.959 10.280  1.000 14.720 0  201  PHE A CE2 1 ? 
ATOM   1615 C CZ  . PHE A 1 201 ? 11.974 25.814 11.085  1.000 15.010 0  201  PHE A CZ  1 ? 
ATOM   1616 N N   . ALA A 1 202 ? 17.912 23.955 14.483  1.000 14.930 0  202  ALA A N   1 ? 
ATOM   1617 C CA  . ALA A 1 202 ? 18.914 23.227 15.234  1.000 16.930 0  202  ALA A CA  1 ? 
ATOM   1618 C C   . ALA A 1 202 ? 18.363 22.927 16.627  1.000 17.320 0  202  ALA A C   1 ? 
ATOM   1619 O O   . ALA A 1 202 ? 17.484 23.641 17.093  1.000 17.440 0  202  ALA A O   1 ? 
ATOM   1620 C CB  . ALA A 1 202 ? 20.185 24.050 15.316  1.000 17.640 0  202  ALA A CB  1 ? 
ATOM   1621 N N   . GLN A 1 203 ? 18.859 21.839 17.222  1.000 16.960 0  203  GLN A N   1 ? 
ATOM   1622 C CA  . GLN A 1 203 ? 18.644 21.508 18.619  1.000 17.730 0  203  GLN A CA  1 ? 
ATOM   1623 C C   . GLN A 1 203 ? 19.852 22.033 19.403  1.000 18.620 0  203  GLN A C   1 ? 
ATOM   1624 O O   . GLN A 1 203 ? 20.984 21.804 18.999  1.000 17.370 0  203  GLN A O   1 ? 
ATOM   1625 C CB  . GLN A 1 203 ? 18.512 20.009 18.834  1.000 19.590 0  203  GLN A CB  1 ? 
ATOM   1626 C CG  . GLN A 1 203 ? 17.337 19.377 18.083  1.000 20.030 0  203  GLN A CG  1 ? 
ATOM   1627 C CD  . GLN A 1 203 ? 16.010 19.954 18.523  1.000 21.490 0  203  GLN A CD  1 ? 
ATOM   1628 O OE1 . GLN A 1 203 ? 15.320 20.644 17.780  1.000 21.810 0  203  GLN A OE1 1 ? 
ATOM   1629 N NE2 . GLN A 1 203 ? 15.693 19.755 19.792  1.000 22.170 0  203  GLN A NE2 1 ? 
ATOM   1630 N N   . PHE A 1 204 ? 19.590 22.703 20.523  1.000 16.140 0  204  PHE A N   1 ? 
ATOM   1631 C CA  . PHE A 1 204 ? 20.652 23.248 21.345  1.000 17.340 0  204  PHE A CA  1 ? 
ATOM   1632 C C   . PHE A 1 204 ? 20.277 23.187 22.815  1.000 16.520 0  204  PHE A C   1 ? 
ATOM   1633 O O   . PHE A 1 204 ? 19.229 23.710 23.205  1.000 17.060 0  204  PHE A O   1 ? 
ATOM   1634 C CB  . PHE A 1 204 ? 20.912 24.687 20.922  1.000 18.250 0  204  PHE A CB  1 ? 
ATOM   1635 C CG  . PHE A 1 204 ? 22.025 25.343 21.706  1.000 17.650 0  204  PHE A CG  1 ? 
ATOM   1636 C CD1 . PHE A 1 204 ? 23.342 25.038 21.431  1.000 18.200 0  204  PHE A CD1 1 ? 
ATOM   1637 C CD2 . PHE A 1 204 ? 21.758 26.224 22.733  1.000 20.660 0  204  PHE A CD2 1 ? 
ATOM   1638 C CE1 . PHE A 1 204 ? 24.372 25.626 22.136  1.000 21.260 0  204  PHE A CE1 1 ? 
ATOM   1639 C CE2 . PHE A 1 204 ? 22.794 26.820 23.444  1.000 19.880 0  204  PHE A CE2 1 ? 
ATOM   1640 C CZ  . PHE A 1 204 ? 24.100 26.511 23.149  1.000 21.020 0  204  PHE A CZ  1 ? 
ATOM   1641 N N   . LYS A 1 205 ? 21.128 22.554 23.623  1.000 16.480 0  205  LYS A N   1 ? 
ATOM   1642 C CA  . LYS A 1 205 ? 20.808 22.453 25.037  1.000 17.860 0  205  LYS A CA  1 ? 
ATOM   1643 C C   . LYS A 1 205 ? 21.630 23.510 25.764  1.000 20.050 0  205  LYS A C   1 ? 
ATOM   1644 O O   . LYS A 1 205 ? 22.853 23.415 25.818  1.000 18.100 0  205  LYS A O   1 ? 
ATOM   1645 C CB  . LYS A 1 205 ? 21.052 21.066 25.622  1.000 21.650 0  205  LYS A CB  1 ? 
ATOM   1646 C CG  . LYS A 1 205 ? 20.596 21.002 27.051  1.000 25.770 0  205  LYS A CG  1 ? 
ATOM   1647 C CD  . LYS A 1 205 ? 20.322 19.590 27.538  1.000 32.700 0  205  LYS A CD  1 ? 
ATOM   1648 C CE  . LYS A 1 205 ? 21.471 18.661 27.542  1.000 41.180 0  205  LYS A CE  1 ? 
ATOM   1649 N NZ  . LYS A 1 205 ? 20.953 17.283 27.646  1.000 45.560 0  205  LYS A NZ  1 ? 
ATOM   1650 N N   . MET A 1 206 ? 20.920 24.501 26.275  1.000 17.870 0  206  MET A N   1 ? 
ATOM   1651 C CA  . MET A 1 206 ? 21.509 25.561 27.066  1.000 21.320 0  206  MET A CA  1 ? 
ATOM   1652 C C   . MET A 1 206 ? 21.997 24.974 28.381  1.000 20.660 0  206  MET A C   1 ? 
ATOM   1653 O O   . MET A 1 206 ? 21.388 24.084 28.956  1.000 18.980 0  206  MET A O   1 ? 
ATOM   1654 C CB  . MET A 1 206 ? 20.481 26.645 27.378  1.000 23.210 0  206  MET A CB  1 ? 
ATOM   1655 C CG  . MET A 1 206 ? 19.948 27.353 26.185  1.000 24.290 0  206  MET A CG  1 ? 
ATOM   1656 S SD  . MET A 1 206 ? 18.519 28.375 26.610  1.000 23.940 0  206  MET A SD  1 ? 
ATOM   1657 C CE  . MET A 1 206 ? 19.181 29.433 27.894  1.000 22.590 0  206  MET A CE  1 ? 
ATOM   1658 N N   . GLU A 1 207 ? 23.138 25.483 28.845  1.000 20.450 0  207  GLU A N   1 ? 
ATOM   1659 C CA  . GLU A 1 207 ? 23.599 25.156 30.178  1.000 22.720 0  207  GLU A CA  1 ? 
ATOM   1660 C C   . GLU A 1 207 ? 22.507 25.450 31.189  1.000 21.050 0  207  GLU A C   1 ? 
ATOM   1661 O O   . GLU A 1 207 ? 21.882 26.513 31.124  1.000 21.340 0  207  GLU A O   1 ? 
ATOM   1662 C CB  . GLU A 1 207 ? 24.853 25.987 30.490  1.000 27.430 0  207  GLU A CB  1 ? 
ATOM   1663 C CG  . GLU A 1 207 ? 25.650 25.441 31.667  1.000 34.680 0  207  GLU A CG  1 ? 
ATOM   1664 C CD  . GLU A 1 207 ? 26.031 23.972 31.544  1.000 41.140 0  207  GLU A CD  1 ? 
ATOM   1665 O OE1 . GLU A 1 207 ? 26.396 23.559 30.416  1.000 36.910 0  207  GLU A OE1 1 ? 
ATOM   1666 O OE2 . GLU A 1 207 ? 25.903 23.230 32.558  1.000 48.280 0  207  GLU A OE2 1 ? 
ATOM   1667 N N   . GLY A 1 208 ? 22.266 24.491 32.097  1.000 22.620 0  208  GLY A N   1 ? 
ATOM   1668 C CA  . GLY A 1 208 ? 21.257 24.647 33.135  1.000 22.730 0  208  GLY A CA  1 ? 
ATOM   1669 C C   . GLY A 1 208 ? 19.880 24.139 32.734  1.000 25.910 0  208  GLY A C   1 ? 
ATOM   1670 O O   . GLY A 1 208 ? 18.986 24.094 33.569  1.000 28.100 0  208  GLY A O   1 ? 
ATOM   1671 N N   . ASN A 1 209 ? 19.682 23.792 31.461  1.000 22.340 0  209  ASN A N   1 ? 
ATOM   1672 C CA  . ASN A 1 209 ? 18.377 23.341 31.003  1.000 21.910 0  209  ASN A CA  1 ? 
ATOM   1673 C C   . ASN A 1 209 ? 18.415 21.824 30.918  1.000 23.440 0  209  ASN A C   1 ? 
ATOM   1674 O O   . ASN A 1 209 ? 19.426 21.260 30.505  1.000 22.450 0  209  ASN A O   1 ? 
ATOM   1675 C CB  . ASN A 1 209 ? 18.015 23.928 29.646  1.000 20.220 0  209  ASN A CB  1 ? 
ATOM   1676 C CG  . ASN A 1 209 ? 17.478 25.325 29.737  1.000 22.560 0  209  ASN A CG  1 ? 
ATOM   1677 O OD1 . ASN A 1 209 ? 17.285 25.853 30.839  1.000 20.180 0  209  ASN A OD1 1 ? 
ATOM   1678 N ND2 . ASN A 1 209 ? 17.177 25.908 28.587  1.000 18.970 0  209  ASN A ND2 1 ? 
ATOM   1679 N N   . ALA A 1 210 ? 17.301 21.170 31.290  1.000 25.790 0  210  ALA A N   1 ? 
ATOM   1680 C CA  . ALA A 1 210 ? 17.229 19.716 31.195  1.000 29.790 0  210  ALA A CA  1 ? 
ATOM   1681 C C   . ALA A 1 210 ? 16.978 19.274 29.756  1.000 28.250 0  210  ALA A C   1 ? 
ATOM   1682 O O   . ALA A 1 210 ? 17.405 18.182 29.369  1.000 30.430 0  210  ALA A O   1 ? 
ATOM   1683 C CB  . ALA A 1 210 ? 16.126 19.178 32.088  1.000 34.110 0  210  ALA A CB  1 ? 
ATOM   1684 N N   . GLU A 1 211 ? 16.296 20.132 28.978  1.000 24.390 0  211  GLU A N   1 ? 
ATOM   1685 C CA  . GLU A 1 211 ? 15.922 19.756 27.617  1.000 23.120 0  211  GLU A CA  1 ? 
ATOM   1686 C C   . GLU A 1 211 ? 16.557 20.681 26.576  1.000 18.690 0  211  GLU A C   1 ? 
ATOM   1687 O O   . GLU A 1 211 ? 16.767 21.841 26.838  1.000 20.450 0  211  GLU A O   1 ? 
ATOM   1688 C CB  . GLU A 1 211 ? 14.402 19.842 27.457  1.000 25.060 0  211  GLU A CB  1 ? 
ATOM   1689 C CG  . GLU A 1 211 ? 13.593 19.014 28.457  1.000 31.780 0  211  GLU A CG  1 ? 
ATOM   1690 C CD  . GLU A 1 211 ? 13.830 17.515 28.428  1.000 41.760 0  211  GLU A CD  1 ? 
ATOM   1691 O OE1 . GLU A 1 211 ? 14.010 16.964 27.315  1.000 44.970 0  211  GLU A OE1 1 ? 
ATOM   1692 O OE2 . GLU A 1 211 ? 13.830 16.888 29.519  1.000 49.660 0  211  GLU A OE2 1 ? 
ATOM   1693 N N   . GLU A 1 212 ? 16.691 20.150 25.371  1.000 19.900 0  212  GLU A N   1 ? 
ATOM   1694 C CA  . GLU A 1 212 ? 17.117 20.880 24.202  1.000 20.460 0  212  GLU A CA  1 ? 
ATOM   1695 C C   . GLU A 1 212 ? 16.089 21.939 23.889  1.000 19.980 0  212  GLU A C   1 ? 
ATOM   1696 O O   . GLU A 1 212 ? 14.890 21.731 24.063  1.000 22.860 0  212  GLU A O   1 ? 
ATOM   1697 C CB  . GLU A 1 212 ? 17.247 19.893 23.043  1.000 23.020 0  212  GLU A CB  1 ? 
ATOM   1698 C CG  . GLU A 1 212 ? 18.463 18.986 23.143  1.000 26.040 0  212  GLU A CG  1 ? 
ATOM   1699 C CD  . GLU A 1 212 ? 18.468 17.904 22.073  1.000 31.570 0  212  GLU A CD  1 ? 
ATOM   1700 O OE1 . GLU A 1 212 ? 17.513 17.836 21.267  1.000 28.690 0  212  GLU A OE1 1 ? 
ATOM   1701 O OE2 . GLU A 1 212 ? 19.425 17.100 22.055  1.000 36.190 0  212  GLU A OE2 1 ? 
ATOM   1702 N N   . SER A 1 213 ? 16.575 23.096 23.452  1.000 16.850 0  213  SER A N   1 ? 
ATOM   1703 C CA  . SER A 1 213 ? 15.774 24.132 22.824  1.000 17.590 0  213  SER A CA  1 ? 
ATOM   1704 C C   . SER A 1 213 ? 15.727 23.832 21.322  1.000 17.930 0  213  SER A C   1 ? 
ATOM   1705 O O   . SER A 1 213 ? 16.714 23.399 20.743  1.000 17.160 0  213  SER A O   1 ? 
ATOM   1706 C CB  . SER A 1 213 ? 16.370 25.512 23.036  1.000 17.300 0  213  SER A CB  1 ? 
ATOM   1707 O OG  . SER A 1 213 ? 16.638 25.810 24.398  1.000 19.490 0  213  SER A OG  1 ? 
ATOM   1708 N N   . THR A 1 214 ? 14.612 24.114 20.667  1.000 16.420 0  214  THR A N   1 ? 
ATOM   1709 C CA  . THR A 1 214 ? 14.565 24.105 19.211  1.000 15.540 0  214  THR A CA  1 ? 
ATOM   1710 C C   . THR A 1 214 ? 14.770 25.515 18.680  1.000 14.660 0  214  THR A C   1 ? 
ATOM   1711 O O   . THR A 1 214 ? 13.991 26.442 18.991  1.000 14.360 0  214  THR A O   1 ? 
ATOM   1712 C CB  . THR A 1 214 ? 13.228 23.557 18.719  1.000 16.630 0  214  THR A CB  1 ? 
ATOM   1713 O OG1 . THR A 1 214 ? 13.097 22.223 19.185  1.000 17.890 0  214  THR A OG1 1 ? 
ATOM   1714 C CG2 . THR A 1 214 ? 13.180 23.537 17.202  1.000 18.150 0  214  THR A CG2 1 ? 
ATOM   1715 N N   . LEU A 1 215 ? 15.857 25.695 17.906  1.000 15.110 0  215  LEU A N   1 ? 
ATOM   1716 C CA  . LEU A 1 215 ? 16.203 27.021 17.408  1.000 16.060 0  215  LEU A CA  1 ? 
ATOM   1717 C C   . LEU A 1 215 ? 15.935 27.129 15.909  1.000 16.190 0  215  LEU A C   1 ? 
ATOM   1718 O O   . LEU A 1 215 ? 16.114 26.156 15.180  1.000 16.410 0  215  LEU A O   1 ? 
ATOM   1719 C CB  . LEU A 1 215 ? 17.650 27.371 17.716  1.000 17.020 0  215  LEU A CB  1 ? 
ATOM   1720 C CG  . LEU A 1 215 ? 18.079 27.194 19.180  1.000 15.840 0  215  LEU A CG  1 ? 
ATOM   1721 C CD1 . LEU A 1 215 ? 19.540 27.587 19.260  1.000 16.360 0  215  LEU A CD1 1 ? 
ATOM   1722 C CD2 . LEU A 1 215 ? 17.187 28.032 20.055  1.000 16.350 0  215  LEU A CD2 1 ? 
ATOM   1723 N N   . PHE A 1 216 ? 15.437 28.295 15.511  1.000 15.640 0  216  PHE A N   1 ? 
ATOM   1724 C CA  . PHE A 1 216 ? 15.323 28.700 14.117  1.000 14.520 0  216  PHE A CA  1 ? 
ATOM   1725 C C   . PHE A 1 216 ? 16.392 29.744 13.821  1.000 15.020 0  216  PHE A C   1 ? 
ATOM   1726 O O   . PHE A 1 216 ? 16.447 30.793 14.474  1.000 15.410 0  216  PHE A O   1 ? 
ATOM   1727 C CB  . PHE A 1 216 ? 13.916 29.247 13.948  1.000 14.570 0  216  PHE A CB  1 ? 
ATOM   1728 C CG  . PHE A 1 216 ? 13.602 29.847 12.593  1.000 14.900 0  216  PHE A CG  1 ? 
ATOM   1729 C CD1 . PHE A 1 216 ? 13.954 29.186 11.428  1.000 16.860 0  216  PHE A CD1 1 ? 
ATOM   1730 C CD2 . PHE A 1 216 ? 12.923 31.055 12.472  1.000 17.250 0  216  PHE A CD2 1 ? 
ATOM   1731 C CE1 . PHE A 1 216 ? 13.671 29.771 10.192  1.000 16.660 0  216  PHE A CE1 1 ? 
ATOM   1732 C CE2 . PHE A 1 216 ? 12.612 31.591 11.226  1.000 18.320 0  216  PHE A CE2 1 ? 
ATOM   1733 C CZ  . PHE A 1 216 ? 12.980 30.929 10.100  1.000 16.010 0  216  PHE A CZ  1 ? 
ATOM   1734 N N   . CYS A 1 217 ? 17.224 29.473 12.807  1.000 14.580 0  217  CYS A N   1 ? 
ATOM   1735 C CA  . CYS A 1 217 ? 18.297 30.385 12.427  1.000 15.560 0  217  CYS A CA  1 ? 
ATOM   1736 C C   . CYS A 1 217 ? 18.082 30.774 10.972  1.000 16.050 0  217  CYS A C   1 ? 
ATOM   1737 O O   . CYS A 1 217 ? 17.851 29.914 10.142  1.000 15.100 0  217  CYS A O   1 ? 
ATOM   1738 C CB  . CYS A 1 217 ? 19.642 29.716 12.627  1.000 18.170 0  217  CYS A CB  1 ? 
ATOM   1739 S SG  . CYS A 1 217 ? 21.020 30.796 12.144  1.000 25.540 0  217  CYS A SG  1 ? 
ATOM   1740 N N   . PHE A 1 218 ? 18.026 32.064 10.678  1.000 14.950 0  218  PHE A N   1 ? 
ATOM   1741 C CA  . PHE A 1 218 ? 17.945 32.431 9.283   1.000 15.040 0  218  PHE A CA  1 ? 
ATOM   1742 C C   . PHE A 1 218 ? 18.794 33.664 9.045   1.000 15.520 0  218  PHE A C   1 ? 
ATOM   1743 O O   . PHE A 1 218 ? 19.014 34.487 9.941   1.000 15.890 0  218  PHE A O   1 ? 
ATOM   1744 C CB  . PHE A 1 218 ? 16.492 32.628 8.846   1.000 15.550 0  218  PHE A CB  1 ? 
ATOM   1745 C CG  . PHE A 1 218 ? 15.796 33.869 9.363   1.000 16.780 0  218  PHE A CG  1 ? 
ATOM   1746 C CD1 . PHE A 1 218 ? 15.205 33.897 10.615  1.000 17.140 0  218  PHE A CD1 1 ? 
ATOM   1747 C CD2 . PHE A 1 218 ? 15.766 35.024 8.581   1.000 20.130 0  218  PHE A CD2 1 ? 
ATOM   1748 C CE1 . PHE A 1 218 ? 14.552 35.059 11.035  1.000 18.920 0  218  PHE A CE1 1 ? 
ATOM   1749 C CE2 . PHE A 1 218 ? 15.119 36.161 9.014   1.000 20.070 0  218  PHE A CE2 1 ? 
ATOM   1750 C CZ  . PHE A 1 218 ? 14.526 36.177 10.247  1.000 18.250 0  218  PHE A CZ  1 ? 
ATOM   1751 N N   . ALA A 1 219 ? 19.251 33.777 7.800   1.000 14.320 0  219  ALA A N   1 ? 
ATOM   1752 C CA  . ALA A 1 219 ? 19.991 34.923 7.338   1.000 14.380 0  219  ALA A CA  1 ? 
ATOM   1753 C C   . ALA A 1 219 ? 19.235 35.580 6.206   1.000 15.470 0  219  ALA A C   1 ? 
ATOM   1754 O O   . ALA A 1 219 ? 18.575 34.922 5.389   1.000 15.150 0  219  ALA A O   1 ? 
ATOM   1755 C CB  . ALA A 1 219 ? 21.329 34.468 6.836   1.000 15.030 0  219  ALA A CB  1 ? 
ATOM   1756 N N   . VAL A 1 220 ? 19.372 36.896 6.158   1.000 16.150 0  220  VAL A N   1 ? 
ATOM   1757 C CA  . VAL A 1 220 ? 18.658 37.675 5.183   1.000 18.170 0  220  VAL A CA  1 ? 
ATOM   1758 C C   . VAL A 1 220 ? 19.539 38.858 4.817   1.000 19.980 0  220  VAL A C   1 ? 
ATOM   1759 O O   . VAL A 1 220 ? 20.206 39.417 5.693   1.000 20.480 0  220  VAL A O   1 ? 
ATOM   1760 C CB  . VAL A 1 220 ? 17.319 38.131 5.755   1.000 17.900 0  220  VAL A CB  1 ? 
ATOM   1761 C CG1 . VAL A 1 220 ? 17.434 38.998 7.015   1.000 17.390 0  220  VAL A CG1 1 ? 
ATOM   1762 C CG2 . VAL A 1 220 ? 16.478 38.815 4.675   1.000 19.870 0  220  VAL A CG2 1 ? 
ATOM   1763 N N   . ARG A 1 221 ? 19.509 39.204 3.537   1.000 19.520 0  221  ARG A N   1 ? 
ATOM   1764 C CA  . ARG A 1 221 ? 19.926 40.527 3.125   1.000 19.390 0  221  ARG A CA  1 ? 
ATOM   1765 C C   . ARG A 1 221 ? 18.664 41.324 2.828   1.000 20.960 0  221  ARG A C   1 ? 
ATOM   1766 O O   . ARG A 1 221 ? 17.945 41.042 1.893   1.000 19.600 0  221  ARG A O   1 ? 
ATOM   1767 C CB  . ARG A 1 221 ? 20.912 40.458 1.963   1.000 20.620 0  221  ARG A CB  1 ? 
ATOM   1768 C CG  . ARG A 1 221 ? 21.448 41.858 1.748   1.000 22.030 0  221  ARG A CG  1 ? 
ATOM   1769 C CD  . ARG A 1 221 ? 22.562 41.854 0.731   1.000 23.270 0  221  ARG A CD  1 ? 
ATOM   1770 N NE  . ARG A 1 221 ? 23.247 43.146 0.768   1.000 25.530 0  221  ARG A NE  1 ? 
ATOM   1771 C CZ  . ARG A 1 221 ? 24.375 43.386 0.116   1.000 27.130 0  221  ARG A CZ  1 ? 
ATOM   1772 N NH1 . ARG A 1 221 ? 24.909 42.430 -0.625  1.000 24.300 0  221  ARG A NH1 1 ? 
ATOM   1773 N NH2 . ARG A 1 221 ? 24.976 44.569 0.278   1.000 28.390 0  221  ARG A NH2 1 ? 
ATOM   1774 N N   . GLY A 1 222 ? 18.319 42.209 3.753   1.000 23.750 0  222  GLY A N   1 ? 
ATOM   1775 C CA  . GLY A 1 222 ? 17.156 43.075 3.608   1.000 27.590 0  222  GLY A CA  1 ? 
ATOM   1776 C C   . GLY A 1 222 ? 17.577 44.405 2.974   1.000 32.150 0  222  GLY A C   1 ? 
ATOM   1777 O O   . GLY A 1 222 ? 18.747 44.587 2.642   1.000 32.960 0  222  GLY A O   1 ? 
ATOM   1778 N N   . GLN A 1 223 ? 16.622 45.324 2.780   1.000 39.340 0  223  GLN A N   1 ? 
ATOM   1779 C CA  . GLN A 1 223 ? 16.941 46.637 2.228   1.000 52.390 0  223  GLN A CA  1 ? 
ATOM   1780 C C   . GLN A 1 223 ? 18.033 47.333 3.053   1.000 53.190 0  223  GLN A C   1 ? 
ATOM   1781 O O   . GLN A 1 223 ? 18.942 47.928 2.469   1.000 48.750 0  223  GLN A O   1 ? 
ATOM   1782 C CB  . GLN A 1 223 ? 15.704 47.529 2.104   1.000 55.500 0  223  GLN A CB  1 ? 
ATOM   1783 C CG  . GLN A 1 223 ? 15.196 47.664 0.675   1.000 60.680 0  223  GLN A CG  1 ? 
ATOM   1784 C CD  . GLN A 1 223 ? 14.067 48.667 0.554   1.000 66.720 0  223  GLN A CD  1 ? 
ATOM   1785 O OE1 . GLN A 1 223 ? 13.368 48.968 1.530   1.000 67.430 0  223  GLN A OE1 1 ? 
ATOM   1786 N NE2 . GLN A 1 223 ? 13.865 49.183 -0.652  1.000 69.510 0  223  GLN A NE2 1 ? 
ATOM   1787 N N   . ALA A 1 224 ? 17.948 47.192 4.391   1.000 50.360 0  224  ALA A N   1 ? 
ATOM   1788 C CA  . ALA A 1 224 ? 18.817 47.862 5.349   1.000 55.170 0  224  ALA A CA  1 ? 
ATOM   1789 C C   . ALA A 1 224 ? 20.106 47.084 5.669   1.000 53.840 0  224  ALA A C   1 ? 
ATOM   1790 O O   . ALA A 1 224 ? 20.889 47.533 6.507   1.000 54.700 0  224  ALA A O   1 ? 
ATOM   1791 C CB  . ALA A 1 224 ? 18.020 48.109 6.611   1.000 59.900 0  224  ALA A CB  1 ? 
ATOM   1792 N N   . GLY A 1 225 ? 20.336 45.935 5.018   1.000 40.650 0  225  GLY A N   1 ? 
ATOM   1793 C CA  . GLY A 1 225 ? 21.571 45.181 5.170   1.000 34.310 0  225  GLY A CA  1 ? 
ATOM   1794 C C   . GLY A 1 225 ? 21.350 43.730 5.629   1.000 26.810 0  225  GLY A C   1 ? 
ATOM   1795 O O   . GLY A 1 225 ? 20.242 43.224 5.753   1.000 24.530 0  225  GLY A O   1 ? 
ATOM   1796 N N   . GLY A 1 226 ? 22.461 43.068 5.887   1.000 22.680 0  226  GLY A N   1 ? 
ATOM   1797 C CA  . GLY A 1 226 ? 22.479 41.645 6.177   1.000 22.060 0  226  GLY A CA  1 ? 
ATOM   1798 C C   . GLY A 1 226 ? 22.236 41.419 7.652   1.000 20.120 0  226  GLY A C   1 ? 
ATOM   1799 O O   . GLY A 1 226 ? 22.839 42.080 8.490   1.000 20.320 0  226  GLY A O   1 ? 
ATOM   1800 N N   . LYS A 1 227 ? 21.432 40.411 7.967   1.000 16.870 0  227  LYS A N   1 ? 
ATOM   1801 C CA  . LYS A 1 227 ? 21.177 40.064 9.347   1.000 18.990 0  227  LYS A CA  1 ? 
ATOM   1802 C C   . LYS A 1 227 ? 21.098 38.538 9.483   1.000 17.010 0  227  LYS A C   1 ? 
ATOM   1803 O O   . LYS A 1 227 ? 20.593 37.838 8.603   1.000 16.860 0  227  LYS A O   1 ? 
ATOM   1804 C CB  . LYS A 1 227 ? 19.876 40.708 9.857   1.000 21.620 0  227  LYS A CB  1 ? 
ATOM   1805 C CG  . LYS A 1 227 ? 19.865 42.183 10.212  1.000 32.790 0  227  LYS A CG  1 ? 
ATOM   1806 C CD  . LYS A 1 227 ? 20.725 42.444 11.446  1.000 39.140 0  227  LYS A CD  1 ? 
ATOM   1807 C CE  . LYS A 1 227 ? 20.781 43.853 11.970  1.000 50.230 0  227  LYS A CE  1 ? 
ATOM   1808 N NZ  . LYS A 1 227 ? 21.461 43.802 13.277  1.000 49.910 0  227  LYS A NZ  1 ? 
ATOM   1809 N N   . LEU A 1 228 ? 21.552 38.062 10.633  1.000 16.820 0  228  LEU A N   1 ? 
ATOM   1810 C CA  . LEU A 1 228 ? 21.393 36.686 11.055  1.000 15.550 0  228  LEU A CA  1 ? 
ATOM   1811 C C   . LEU A 1 228 ? 20.592 36.658 12.347  1.000 16.770 0  228  LEU A C   1 ? 
ATOM   1812 O O   . LEU A 1 228 ? 20.968 37.258 13.354  1.000 17.500 0  228  LEU A O   1 ? 
ATOM   1813 C CB  . LEU A 1 228 ? 22.718 35.989 11.289  1.000 17.860 0  228  LEU A CB  1 ? 
ATOM   1814 C CG  . LEU A 1 228 ? 22.650 34.570 11.844  1.000 19.270 0  228  LEU A CG  1 ? 
ATOM   1815 C CD1 . LEU A 1 228 ? 22.317 33.711 10.687  1.000 24.080 0  228  LEU A CD1 1 ? 
ATOM   1816 C CD2 . LEU A 1 228 ? 23.933 34.109 12.482  1.000 23.550 0  228  LEU A CD2 1 ? 
ATOM   1817 N N   . HIS A 1 229 ? 19.544 35.844 12.352  1.000 15.360 0  229  HIS A N   1 ? 
ATOM   1818 C CA  . HIS A 1 229 ? 18.680 35.743 13.515  1.000 16.420 0  229  HIS A CA  1 ? 
ATOM   1819 C C   . HIS A 1 229 ? 18.729 34.320 14.036  1.000 17.010 0  229  HIS A C   1 ? 
ATOM   1820 O O   . HIS A 1 229 ? 18.694 33.374 13.248  1.000 17.330 0  229  HIS A O   1 ? 
ATOM   1821 C CB  . HIS A 1 229 ? 17.243 36.042 13.124  1.000 16.630 0  229  HIS A CB  1 ? 
ATOM   1822 C CG  . HIS A 1 229 ? 17.036 37.427 12.652  1.000 19.920 0  229  HIS A CG  1 ? 
ATOM   1823 N ND1 . HIS A 1 229 ? 16.727 38.427 13.557  1.000 22.110 0  229  HIS A ND1 1 ? 
ATOM   1824 C CD2 . HIS A 1 229 ? 17.079 38.008 11.437  1.000 21.370 0  229  HIS A CD2 1 ? 
ATOM   1825 C CE1 . HIS A 1 229 ? 16.603 39.572 12.902  1.000 23.850 0  229  HIS A CE1 1 ? 
ATOM   1826 N NE2 . HIS A 1 229 ? 16.802 39.347 11.621  1.000 23.570 0  229  HIS A NE2 1 ? 
ATOM   1827 N N   . ILE A 1 230 ? 18.795 34.179 15.363  1.000 15.930 0  230  ILE A N   1 ? 
ATOM   1828 C CA  . ILE A 1 230 ? 18.734 32.884 16.017  1.000 13.820 0  230  ILE A CA  1 ? 
ATOM   1829 C C   . ILE A 1 230 ? 17.659 33.023 17.100  1.000 14.790 0  230  ILE A C   1 ? 
ATOM   1830 O O   . ILE A 1 230 ? 17.821 33.802 18.043  1.000 14.830 0  230  ILE A O   1 ? 
ATOM   1831 C CB  . ILE A 1 230 ? 20.096 32.475 16.610  1.000 14.850 0  230  ILE A CB  1 ? 
ATOM   1832 C CG1 . ILE A 1 230 ? 21.230 32.608 15.546  1.000 16.890 0  230  ILE A CG1 1 ? 
ATOM   1833 C CG2 . ILE A 1 230 ? 20.052 31.076 17.211  1.000 14.930 0  230  ILE A CG2 1 ? 
ATOM   1834 C CD1 . ILE A 1 230 ? 22.610 32.691 16.159  1.000 18.810 0  230  ILE A CD1 1 ? 
ATOM   1835 N N   . ILE A 1 231 ? 16.605 32.239 16.963  1.000 14.650 0  231  ILE A N   1 ? 
ATOM   1836 C CA  . ILE A 1 231 ? 15.462 32.414 17.849  1.000 16.370 0  231  ILE A CA  1 ? 
ATOM   1837 C C   . ILE A 1 231 ? 14.818 31.063 18.158  1.000 17.240 0  231  ILE A C   1 ? 
ATOM   1838 O O   . ILE A 1 231 ? 14.724 30.156 17.326  1.000 15.520 0  231  ILE A O   1 ? 
ATOM   1839 C CB  . ILE A 1 231 ? 14.484 33.425 17.214  1.000 22.220 0  231  ILE A CB  1 ? 
ATOM   1840 C CG1 . ILE A 1 231 ? 13.300 33.737 18.131  1.000 23.650 0  231  ILE A CG1 1 ? 
ATOM   1841 C CG2 . ILE A 1 231 ? 13.998 32.938 15.857  1.000 25.410 0  231  ILE A CG2 1 ? 
ATOM   1842 C CD1 . ILE A 1 231 ? 12.620 35.032 17.784  1.000 28.640 0  231  ILE A CD1 1 ? 
ATOM   1843 N N   . GLU A 1 232 ? 14.364 30.946 19.416  1.000 16.360 0  232  GLU A N   1 ? 
ATOM   1844 C CA  . GLU A 1 232 ? 13.682 29.752 19.878  1.000 15.930 0  232  GLU A CA  1 ? 
ATOM   1845 C C   . GLU A 1 232 ? 12.303 29.751 19.258  1.000 15.680 0  232  GLU A C   1 ? 
ATOM   1846 O O   . GLU A 1 232 ? 11.650 30.785 19.233  1.000 17.670 0  232  GLU A O   1 ? 
ATOM   1847 C CB  . GLU A 1 232 ? 13.568 29.737 21.402  1.000 16.610 0  232  GLU A CB  1 ? 
ATOM   1848 C CG  . GLU A 1 232 ? 12.996 28.447 21.953  1.000 16.650 0  232  GLU A CG  1 ? 
ATOM   1849 C CD  . GLU A 1 232 ? 13.251 28.222 23.435  1.000 18.410 0  232  GLU A CD  1 ? 
ATOM   1850 O OE1 . GLU A 1 232 ? 13.475 29.224 24.129  1.000 19.270 0  232  GLU A OE1 1 ? 
ATOM   1851 O OE2 . GLU A 1 232 ? 13.180 27.048 23.861  1.000 20.110 0  232  GLU A OE2 1 ? 
ATOM   1852 N N   . VAL A 1 233 ? 11.871 28.594 18.768  1.000 16.010 0  233  VAL A N   1 ? 
ATOM   1853 C CA  . VAL A 1 233 ? 10.492 28.488 18.291  1.000 16.710 0  233  VAL A CA  1 ? 
ATOM   1854 C C   . VAL A 1 233 ? 9.708  27.703 19.324  1.000 18.950 0  233  VAL A C   1 ? 
ATOM   1855 O O   . VAL A 1 233 ? 10.150 26.628 19.751  1.000 20.110 0  233  VAL A O   1 ? 
ATOM   1856 C CB  . VAL A 1 233 ? 10.348 27.846 16.904  1.000 16.760 0  233  VAL A CB  1 ? 
ATOM   1857 C CG1 . VAL A 1 233 ? 10.825 28.830 15.873  1.000 19.620 0  233  VAL A CG1 1 ? 
ATOM   1858 C CG2 . VAL A 1 233 ? 11.098 26.540 16.762  1.000 16.730 0  233  VAL A CG2 1 ? 
ATOM   1859 N N   . GLY A 1 234 ? 8.564  28.284 19.694  1.000 20.670 0  234  GLY A N   1 ? 
ATOM   1860 C CA  . GLY A 1 234 ? 7.666  27.612 20.618  1.000 23.040 0  234  GLY A CA  1 ? 
ATOM   1861 C C   . GLY A 1 234 ? 8.004  27.935 22.066  1.000 24.130 0  234  GLY A C   1 ? 
ATOM   1862 O O   . GLY A 1 234 ? 9.056  28.476 22.379  1.000 24.040 0  234  GLY A O   1 ? 
ATOM   1863 N N   . THR A 1 235 ? 7.079  27.542 22.948  1.000 21.870 0  235  THR A N   1 ? 
ATOM   1864 C CA  . THR A 1 235 ? 7.296  27.730 24.393  1.000 20.170 0  235  THR A CA  1 ? 
ATOM   1865 C C   . THR A 1 235 ? 8.411  26.810 24.821  1.000 18.060 0  235  THR A C   1 ? 
ATOM   1866 O O   . THR A 1 235 ? 8.429  25.642 24.379  1.000 20.820 0  235  THR A O   1 ? 
ATOM   1867 C CB  . THR A 1 235 ? 6.001  27.409 25.139  1.000 21.120 0  235  THR A CB  1 ? 
ATOM   1868 O OG1 . THR A 1 235 ? 5.029  28.332 24.657  1.000 21.970 0  235  THR A OG1 1 ? 
ATOM   1869 C CG2 . THR A 1 235 ? 6.136  27.556 26.644  1.000 24.720 0  235  THR A CG2 1 ? 
ATOM   1870 N N   . PRO A 1 236 ? 9.353  27.278 25.662  1.000 20.360 0  236  PRO A N   1 ? 
ATOM   1871 C CA  . PRO A 1 236 ? 10.419 26.412 26.182  1.000 25.660 0  236  PRO A CA  1 ? 
ATOM   1872 C C   . PRO A 1 236 ? 9.873  25.140 26.836  1.000 29.270 0  236  PRO A C   1 ? 
ATOM   1873 O O   . PRO A 1 236 ? 8.846  25.190 27.526  1.000 29.760 0  236  PRO A O   1 ? 
ATOM   1874 C CB  . PRO A 1 236 ? 11.149 27.303 27.155  1.000 23.420 0  236  PRO A CB  1 ? 
ATOM   1875 C CG  . PRO A 1 236 ? 10.863 28.712 26.662  1.000 23.180 0  236  PRO A CG  1 ? 
ATOM   1876 C CD  . PRO A 1 236 ? 9.426  28.665 26.133  1.000 21.080 0  236  PRO A CD  1 ? 
ATOM   1877 N N   . PRO A 1 237 ? 10.511 23.969 26.623  1.000 25.400 0  237  PRO A N   1 ? 
ATOM   1878 C CA  . PRO A 1 237 ? 10.176 22.761 27.376  1.000 29.050 0  237  PRO A CA  1 ? 
ATOM   1879 C C   . PRO A 1 237 ? 10.007 23.119 28.846  1.000 32.120 0  237  PRO A C   1 ? 
ATOM   1880 O O   . PRO A 1 237 ? 10.751 23.945 29.368  1.000 29.820 0  237  PRO A O   1 ? 
ATOM   1881 C CB  . PRO A 1 237 ? 11.389 21.873 27.134  1.000 28.650 0  237  PRO A CB  1 ? 
ATOM   1882 C CG  . PRO A 1 237 ? 11.895 22.276 25.759  1.000 27.880 0  237  PRO A CG  1 ? 
ATOM   1883 C CD  . PRO A 1 237 ? 11.625 23.751 25.678  1.000 28.480 0  237  PRO A CD  1 ? 
ATOM   1884 N N   . THR A 1 238 ? 9.017  22.542 29.546  1.000 32.820 0  238  THR A N   1 ? 
ATOM   1885 C CA  . THR A 1 238 ? 8.844  22.942 30.938  1.000 34.380 0  238  THR A CA  1 ? 
ATOM   1886 C C   . THR A 1 238 ? 10.127 22.605 31.705  1.000 32.030 0  238  THR A C   1 ? 
ATOM   1887 O O   . THR A 1 238 ? 10.789 21.602 31.455  1.000 35.370 0  238  THR A O   1 ? 
ATOM   1888 C CB  . THR A 1 238 ? 7.592  22.302 31.547  1.000 43.940 0  238  THR A CB  1 ? 
ATOM   1889 O OG1 . THR A 1 238 ? 7.924  20.925 31.655  1.000 45.620 0  238  THR A OG1 1 ? 
ATOM   1890 C CG2 . THR A 1 238 ? 6.344  22.493 30.701  1.000 41.260 0  238  THR A CG2 1 ? 
ATOM   1891 N N   . GLY A 1 239 ? 10.547 23.494 32.597  1.000 35.260 0  239  GLY A N   1 ? 
ATOM   1892 C CA  . GLY A 1 239 ? 11.845 23.326 33.228  1.000 33.740 0  239  GLY A CA  1 ? 
ATOM   1893 C C   . GLY A 1 239 ? 12.887 24.301 32.676  1.000 34.100 0  239  GLY A C   1 ? 
ATOM   1894 O O   . GLY A 1 239 ? 13.690 24.811 33.445  1.000 34.200 0  239  GLY A O   1 ? 
ATOM   1895 N N   . ASN A 1 240 ? 12.849 24.581 31.362  1.000 27.550 0  240  ASN A N   1 ? 
ATOM   1896 C CA  . ASN A 1 240 ? 13.902 25.318 30.683  1.000 25.180 0  240  ASN A CA  1 ? 
ATOM   1897 C C   . ASN A 1 240 ? 13.786 26.814 30.869  1.000 22.150 0  240  ASN A C   1 ? 
ATOM   1898 O O   . ASN A 1 240 ? 12.703 27.381 30.838  1.000 22.160 0  240  ASN A O   1 ? 
ATOM   1899 C CB  . ASN A 1 240 ? 13.855 25.116 29.174  1.000 21.540 0  240  ASN A CB  1 ? 
ATOM   1900 C CG  . ASN A 1 240 ? 14.548 23.856 28.727  1.000 22.180 0  240  ASN A CG  1 ? 
ATOM   1901 O OD1 . ASN A 1 240 ? 14.827 22.959 29.528  1.000 21.370 0  240  ASN A OD1 1 ? 
ATOM   1902 N ND2 . ASN A 1 240 ? 14.827 23.771 27.433  1.000 21.830 0  240  ASN A ND2 1 ? 
ATOM   1903 N N   . GLN A 1 241 ? 14.943 27.460 30.920  1.000 19.160 0  241  GLN A N   1 ? 
ATOM   1904 C CA  . GLN A 1 241 ? 15.034 28.865 30.620  1.000 21.370 0  241  GLN A CA  1 ? 
ATOM   1905 C C   . GLN A 1 241 ? 14.861 29.027 29.117  1.000 19.160 0  241  GLN A C   1 ? 
ATOM   1906 O O   . GLN A 1 241 ? 15.303 28.177 28.337  1.000 20.370 0  241  GLN A O   1 ? 
ATOM   1907 C CB  . GLN A 1 241 ? 16.418 29.362 31.054  1.000 25.620 0  241  GLN A CB  1 ? 
ATOM   1908 C CG  . GLN A 1 241 ? 16.586 29.370 32.566  1.000 32.290 0  241  GLN A CG  1 ? 
ATOM   1909 C CD  . GLN A 1 241 ? 15.571 30.276 33.236  1.000 36.170 0  241  GLN A CD  1 ? 
ATOM   1910 O OE1 . GLN A 1 241 ? 15.348 31.409 32.807  1.000 36.800 0  241  GLN A OE1 1 ? 
ATOM   1911 N NE2 . GLN A 1 241 ? 14.872 29.756 34.234  1.000 46.930 0  241  GLN A NE2 1 ? 
ATOM   1912 N N   . PRO A 1 242 ? 14.223 30.114 28.691  1.000 20.470 0  242  PRO A N   1 ? 
ATOM   1913 C CA  . PRO A 1 242 ? 14.134 30.444 27.270  1.000 19.270 0  242  PRO A CA  1 ? 
ATOM   1914 C C   . PRO A 1 242 ? 15.498 30.813 26.690  1.000 20.670 0  242  PRO A C   1 ? 
ATOM   1915 O O   . PRO A 1 242 ? 16.360 31.390 27.372  1.000 19.580 0  242  PRO A O   1 ? 
ATOM   1916 C CB  . PRO A 1 242 ? 13.175 31.652 27.199  1.000 22.230 0  242  PRO A CB  1 ? 
ATOM   1917 C CG  . PRO A 1 242 ? 12.952 32.083 28.617  1.000 24.790 0  242  PRO A CG  1 ? 
ATOM   1918 C CD  . PRO A 1 242 ? 13.488 31.054 29.559  1.000 22.860 0  242  PRO A CD  1 ? 
ATOM   1919 N N   . PHE A 1 243 ? 15.704 30.448 25.429  1.000 19.560 0  243  PHE A N   1 ? 
ATOM   1920 C CA  . PHE A 1 243 ? 16.902 30.874 24.715  1.000 18.870 0  243  PHE A CA  1 ? 
ATOM   1921 C C   . PHE A 1 243 ? 16.765 32.338 24.316  1.000 18.950 0  243  PHE A C   1 ? 
ATOM   1922 O O   . PHE A 1 243 ? 15.814 32.773 23.665  1.000 18.880 0  243  PHE A O   1 ? 
ATOM   1923 C CB  . PHE A 1 243 ? 17.025 29.998 23.458  1.000 17.170 0  243  PHE A CB  1 ? 
ATOM   1924 C CG  . PHE A 1 243 ? 18.248 30.340 22.622  1.000 16.720 0  243  PHE A CG  1 ? 
ATOM   1925 C CD1 . PHE A 1 243 ? 19.451 29.763 22.950  1.000 17.300 0  243  PHE A CD1 1 ? 
ATOM   1926 C CD2 . PHE A 1 243 ? 18.185 31.244 21.564  1.000 16.900 0  243  PHE A CD2 1 ? 
ATOM   1927 C CE1 . PHE A 1 243 ? 20.595 30.056 22.220  1.000 17.970 0  243  PHE A CE1 1 ? 
ATOM   1928 C CE2 . PHE A 1 243 ? 19.336 31.536 20.835  1.000 16.980 0  243  PHE A CE2 1 ? 
ATOM   1929 C CZ  . PHE A 1 243 ? 20.512 30.915 21.162  1.000 16.000 0  243  PHE A CZ  1 ? 
ATOM   1930 N N   . PRO A 1 244 ? 17.667 33.222 24.754  1.000 18.630 0  244  PRO A N   1 ? 
ATOM   1931 C CA  . PRO A 1 244 ? 17.572 34.622 24.375  1.000 20.250 0  244  PRO A CA  1 ? 
ATOM   1932 C C   . PRO A 1 244 ? 17.886 34.799 22.884  1.000 18.420 0  244  PRO A C   1 ? 
ATOM   1933 O O   . PRO A 1 244 ? 18.950 34.365 22.445  1.000 18.140 0  244  PRO A O   1 ? 
ATOM   1934 C CB  . PRO A 1 244 ? 18.640 35.338 25.212  1.000 22.730 0  244  PRO A CB  1 ? 
ATOM   1935 C CG  . PRO A 1 244 ? 19.257 34.280 26.073  1.000 23.430 0  244  PRO A CG  1 ? 
ATOM   1936 C CD  . PRO A 1 244 ? 18.777 32.910 25.663  1.000 20.960 0  244  PRO A CD  1 ? 
ATOM   1937 N N   . LYS A 1 245 ? 17.009 35.514 22.201  1.000 19.180 0  245  LYS A N   1 ? 
ATOM   1938 C CA  . LYS A 1 245 ? 17.063 35.661 20.758  1.000 19.620 0  245  LYS A CA  1 ? 
ATOM   1939 C C   . LYS A 1 245 ? 18.288 36.493 20.401  1.000 19.400 0  245  LYS A C   1 ? 
ATOM   1940 O O   . LYS A 1 245 ? 18.685 37.391 21.144  1.000 20.340 0  245  LYS A O   1 ? 
ATOM   1941 C CB  . LYS A 1 245 ? 15.809 36.317 20.186  1.000 24.080 0  245  LYS A CB  1 ? 
ATOM   1942 C CG  . LYS A 1 245 ? 15.561 37.791 20.486  1.000 28.070 0  245  LYS A CG  1 ? 
ATOM   1943 C CD  . LYS A 1 245 ? 14.190 38.202 19.982  1.000 34.520 0  245  LYS A CD  1 ? 
ATOM   1944 C CE  . LYS A 1 245 ? 13.629 39.402 20.684  1.000 46.030 0  245  LYS A CE  1 ? 
ATOM   1945 N NZ  . LYS A 1 245 ? 13.868 40.595 19.880  1.000 51.140 0  245  LYS A NZ  1 ? 
ATOM   1946 N N   . LYS A 1 246 ? 18.929 36.128 19.299  1.000 17.620 0  246  LYS A N   1 ? 
ATOM   1947 C CA  . LYS A 1 246 ? 20.089 36.859 18.819  1.000 17.540 0  246  LYS A CA  1 ? 
ATOM   1948 C C   . LYS A 1 246 ? 19.779 37.412 17.439  1.000 16.910 0  246  LYS A C   1 ? 
ATOM   1949 O O   . LYS A 1 246 ? 19.099 36.757 16.626  1.000 17.790 0  246  LYS A O   1 ? 
ATOM   1950 C CB  . LYS A 1 246 ? 21.294 35.932 18.715  1.000 18.940 0  246  LYS A CB  1 ? 
ATOM   1951 C CG  . LYS A 1 246 ? 21.556 35.064 19.934  1.000 22.370 0  246  LYS A CG  1 ? 
ATOM   1952 C CD  . LYS A 1 246 ? 21.792 35.890 21.179  1.000 25.280 0  246  LYS A CD  1 ? 
ATOM   1953 C CE  . LYS A 1 246 ? 22.246 35.107 22.389  1.000 24.990 0  246  LYS A CE  1 ? 
ATOM   1954 N NZ  . LYS A 1 246 ? 21.584 33.814 22.626  1.000 24.340 0  246  LYS A NZ  1 ? 
ATOM   1955 N N   . ALA A 1 247 ? 20.291 38.615 17.187  1.000 18.550 0  247  ALA A N   1 ? 
ATOM   1956 C CA  . ALA A 1 247 ? 20.243 39.245 15.881  1.000 18.900 0  247  ALA A CA  1 ? 
ATOM   1957 C C   . ALA A 1 247 ? 21.600 39.900 15.628  1.000 21.480 0  247  ALA A C   1 ? 
ATOM   1958 O O   . ALA A 1 247 ? 22.006 40.780 16.386  1.000 24.160 0  247  ALA A O   1 ? 
ATOM   1959 C CB  . ALA A 1 247 ? 19.124 40.260 15.806  1.000 20.140 0  247  ALA A CB  1 ? 
ATOM   1960 N N   . VAL A 1 248 ? 22.333 39.413 14.634  1.000 18.720 0  248  VAL A N   1 ? 
ATOM   1961 C CA  . VAL A 1 248 ? 23.668 39.937 14.385  1.000 19.700 0  248  VAL A CA  1 ? 
ATOM   1962 C C   . VAL A 1 248 ? 23.763 40.362 12.931  1.000 21.560 0  248  VAL A C   1 ? 
ATOM   1963 O O   . VAL A 1 248 ? 23.024 39.903 12.054  1.000 20.340 0  248  VAL A O   1 ? 
ATOM   1964 C CB  . VAL A 1 248 ? 24.755 38.907 14.713  1.000 23.320 0  248  VAL A CB  1 ? 
ATOM   1965 C CG1 . VAL A 1 248 ? 24.777 38.542 16.188  1.000 28.550 0  248  VAL A CG1 1 ? 
ATOM   1966 C CG2 . VAL A 1 248 ? 24.603 37.649 13.857  1.000 22.460 0  248  VAL A CG2 1 ? 
ATOM   1967 N N   . ASP A 1 249 ? 24.756 41.192 12.651  1.000 20.240 0  249  ASP A N   1 ? 
ATOM   1968 C CA  . ASP A 1 249 ? 24.967 41.618 11.284  1.000 21.300 0  249  ASP A CA  1 ? 
ATOM   1969 C C   . ASP A 1 249 ? 25.579 40.478 10.472  1.000 19.810 0  249  ASP A C   1 ? 
ATOM   1970 O O   . ASP A 1 249 ? 26.361 39.673 10.969  1.000 21.620 0  249  ASP A O   1 ? 
ATOM   1971 C CB  . ASP A 1 249 ? 25.889 42.829 11.200  1.000 27.330 0  249  ASP A CB  1 ? 
ATOM   1972 C CG  . ASP A 1 249 ? 25.347 44.077 11.886  1.000 37.100 0  249  ASP A CG  1 ? 
ATOM   1973 O OD1 . ASP A 1 249 ? 24.103 44.320 11.824  1.000 35.630 0  249  ASP A OD1 1 ? 
ATOM   1974 O OD2 . ASP A 1 249 ? 26.170 44.810 12.477  1.000 52.740 0  249  ASP A OD2 1 ? 
ATOM   1975 N N   . VAL A 1 250 ? 25.265 40.503 9.190   1.000 19.280 0  250  VAL A N   1 ? 
ATOM   1976 C CA  . VAL A 1 250 ? 25.888 39.667 8.190   1.000 19.530 0  250  VAL A CA  1 ? 
ATOM   1977 C C   . VAL A 1 250 ? 26.558 40.645 7.226   1.000 20.420 0  250  VAL A C   1 ? 
ATOM   1978 O O   . VAL A 1 250 ? 25.860 41.400 6.563   1.000 21.560 0  250  VAL A O   1 ? 
ATOM   1979 C CB  . VAL A 1 250 ? 24.892 38.759 7.451   1.000 19.330 0  250  VAL A CB  1 ? 
ATOM   1980 C CG1 . VAL A 1 250 ? 25.546 37.997 6.306   1.000 22.030 0  250  VAL A CG1 1 ? 
ATOM   1981 C CG2 . VAL A 1 250 ? 24.230 37.771 8.404   1.000 21.090 0  250  VAL A CG2 1 ? 
ATOM   1982 N N   . PHE A 1 251 ? 27.890 40.600 7.204   1.000 22.700 0  251  PHE A N   1 ? 
ATOM   1983 C CA  . PHE A 1 251 ? 28.689 41.562 6.455   1.000 22.180 0  251  PHE A CA  1 ? 
ATOM   1984 C C   . PHE A 1 251 ? 28.711 41.200 4.972   1.000 21.530 0  251  PHE A C   1 ? 
ATOM   1985 O O   . PHE A 1 251 ? 28.858 40.041 4.583   1.000 21.910 0  251  PHE A O   1 ? 
ATOM   1986 C CB  . PHE A 1 251 ? 30.089 41.599 7.053   1.000 26.320 0  251  PHE A CB  1 ? 
ATOM   1987 C CG  . PHE A 1 251 ? 30.995 42.568 6.297   1.000 25.610 0  251  PHE A CG  1 ? 
ATOM   1988 C CD1 . PHE A 1 251 ? 30.819 43.937 6.444   1.000 28.650 0  251  PHE A CD1 1 ? 
ATOM   1989 C CD2 . PHE A 1 251 ? 31.967 42.102 5.425   1.000 29.950 0  251  PHE A CD2 1 ? 
ATOM   1990 C CE1 . PHE A 1 251 ? 31.665 44.830 5.774   1.000 31.800 0  251  PHE A CE1 1 ? 
ATOM   1991 C CE2 . PHE A 1 251 ? 32.805 43.002 4.744   1.000 32.060 0  251  PHE A CE2 1 ? 
ATOM   1992 C CZ  . PHE A 1 251 ? 32.670 44.348 4.949   1.000 28.550 0  251  PHE A CZ  1 ? 
ATOM   1993 N N   . PHE A 1 252 ? 28.488 42.211 4.139   1.000 21.710 0  252  PHE A N   1 ? 
ATOM   1994 C CA  . PHE A 1 252 ? 28.810 42.125 2.726   1.000 24.430 0  252  PHE A CA  1 ? 
ATOM   1995 C C   . PHE A 1 252 ? 29.737 43.278 2.347   1.000 25.060 0  252  PHE A C   1 ? 
ATOM   1996 O O   . PHE A 1 252 ? 29.436 44.443 2.645   1.000 26.330 0  252  PHE A O   1 ? 
ATOM   1997 C CB  . PHE A 1 252 ? 27.571 42.246 1.854   1.000 23.260 0  252  PHE A CB  1 ? 
ATOM   1998 C CG  . PHE A 1 252 ? 26.597 41.108 2.077   1.000 22.970 0  252  PHE A CG  1 ? 
ATOM   1999 C CD1 . PHE A 1 252 ? 26.742 39.913 1.390   1.000 24.790 0  252  PHE A CD1 1 ? 
ATOM   2000 C CD2 . PHE A 1 252 ? 25.575 41.210 3.024   1.000 24.460 0  252  PHE A CD2 1 ? 
ATOM   2001 C CE1 . PHE A 1 252 ? 25.898 38.845 1.633   1.000 23.220 0  252  PHE A CE1 1 ? 
ATOM   2002 C CE2 . PHE A 1 252 ? 24.733 40.130 3.250   1.000 22.620 0  252  PHE A CE2 1 ? 
ATOM   2003 C CZ  . PHE A 1 252 ? 24.901 38.965 2.574   1.000 22.500 0  252  PHE A CZ  1 ? 
ATOM   2004 N N   . PRO A 1 253 ? 30.875 42.968 1.689   1.000 28.170 0  253  PRO A N   1 ? 
ATOM   2005 C CA  . PRO A 1 253 ? 31.837 44.009 1.331   1.000 30.640 0  253  PRO A CA  1 ? 
ATOM   2006 C C   . PRO A 1 253 ? 31.250 44.935 0.266   1.000 30.430 0  253  PRO A C   1 ? 
ATOM   2007 O O   . PRO A 1 253 ? 30.269 44.631 -0.407  1.000 24.600 0  253  PRO A O   1 ? 
ATOM   2008 C CB  . PRO A 1 253 ? 33.106 43.228 0.920   1.000 29.430 0  253  PRO A CB  1 ? 
ATOM   2009 C CG  . PRO A 1 253 ? 32.604 41.875 0.488   1.000 32.750 0  253  PRO A CG  1 ? 
ATOM   2010 C CD  . PRO A 1 253 ? 31.309 41.620 1.282   1.000 28.920 0  253  PRO A CD  1 ? 
ATOM   2011 N N   . PRO A 1 254 ? 31.791 46.164 0.120   1.000 28.840 0  254  PRO A N   1 ? 
ATOM   2012 C CA  . PRO A 1 254 ? 31.181 47.125 -0.790  1.000 30.120 0  254  PRO A CA  1 ? 
ATOM   2013 C C   . PRO A 1 254 ? 31.109 46.629 -2.239  1.000 26.490 0  254  PRO A C   1 ? 
ATOM   2014 O O   . PRO A 1 254 ? 30.176 46.969 -2.944  1.000 29.420 0  254  PRO A O   1 ? 
ATOM   2015 C CB  . PRO A 1 254 ? 32.023 48.400 -0.622  1.000 31.650 0  254  PRO A CB  1 ? 
ATOM   2016 C CG  . PRO A 1 254 ? 33.235 48.004 0.190   1.000 32.690 0  254  PRO A CG  1 ? 
ATOM   2017 C CD  . PRO A 1 254 ? 32.943 46.681 0.879   1.000 33.560 0  254  PRO A CD  1 ? 
ATOM   2018 N N   . GLU A 1 255 ? 32.058 45.786 -2.665  1.000 26.960 0  255  GLU A N   1 ? 
ATOM   2019 C CA  . GLU A 1 255 ? 32.054 45.279 -4.038  1.000 29.810 0  255  GLU A CA  1 ? 
ATOM   2020 C C   . GLU A 1 255 ? 31.070 44.112 -4.226  1.000 28.760 0  255  GLU A C   1 ? 
ATOM   2021 O O   . GLU A 1 255 ? 30.913 43.625 -5.359  1.000 27.240 0  255  GLU A O   1 ? 
ATOM   2022 C CB  . GLU A 1 255 ? 33.482 44.935 -4.457  1.000 34.580 0  255  GLU A CB  1 ? 
ATOM   2023 C CG  . GLU A 1 255 ? 34.213 43.929 -3.563  1.000 44.410 0  255  GLU A CG  1 ? 
ATOM   2024 C CD  . GLU A 1 255 ? 34.839 44.362 -2.225  1.000 47.440 0  255  GLU A CD  1 ? 
ATOM   2025 O OE1 . GLU A 1 255 ? 34.539 45.474 -1.753  1.000 42.900 0  255  GLU A OE1 1 ? 
ATOM   2026 O OE2 . GLU A 1 255 ? 35.628 43.564 -1.637  1.000 49.490 0  255  GLU A OE2 1 ? 
ATOM   2027 N N   . ALA A 1 256 ? 30.408 43.666 -3.137  1.000 26.810 0  256  ALA A N   1 ? 
ATOM   2028 C CA  . ALA A 1 256 ? 29.412 42.599 -3.244  1.000 29.120 0  256  ALA A CA  1 ? 
ATOM   2029 C C   . ALA A 1 256 ? 28.010 43.123 -2.957  1.000 34.390 0  256  ALA A C   1 ? 
ATOM   2030 O O   . ALA A 1 256 ? 27.281 42.514 -2.170  1.000 31.290 0  256  ALA A O   1 ? 
ATOM   2031 C CB  . ALA A 1 256 ? 29.740 41.467 -2.305  1.000 29.690 0  256  ALA A CB  1 ? 
ATOM   2032 N N   . GLN A 1 257 ? 27.614 44.203 -3.646  1.000 33.610 0  257  GLN A N   1 ? 
ATOM   2033 C CA  . GLN A 1 257 ? 26.351 44.865 -3.363  1.000 36.800 0  257  GLN A CA  1 ? 
ATOM   2034 C C   . GLN A 1 257 ? 25.173 43.979 -3.747  1.000 29.710 0  257  GLN A C   1 ? 
ATOM   2035 O O   . GLN A 1 257 ? 24.042 44.245 -3.318  1.000 30.520 0  257  GLN A O   1 ? 
ATOM   2036 C CB  . GLN A 1 257 ? 26.116 46.150 -4.162  1.000 41.160 0  257  GLN A CB  1 ? 
ATOM   2037 C CG  . GLN A 1 257 ? 27.178 47.214 -3.957  1.000 48.470 0  257  GLN A CG  1 ? 
ATOM   2038 C CD  . GLN A 1 257 ? 28.398 47.018 -4.838  1.000 65.660 0  257  GLN A CD  1 ? 
ATOM   2039 O OE1 . GLN A 1 257 ? 28.579 45.997 -5.526  1.000 50.600 0  257  GLN A OE1 1 ? 
ATOM   2040 N NE2 . GLN A 1 257 ? 29.267 48.020 -4.811  1.000 73.370 0  257  GLN A NE2 1 ? 
ATOM   2041 N N   . ASN A 1 258 ? 25.405 42.989 -4.619  1.000 27.630 0  258  ASN A N   1 ? 
ATOM   2042 C CA  . ASN A 1 258 ? 24.342 42.143 -5.124  1.000 25.700 0  258  ASN A CA  1 ? 
ATOM   2043 C C   . ASN A 1 258 ? 24.374 40.725 -4.537  1.000 25.370 0  258  ASN A C   1 ? 
ATOM   2044 O O   . ASN A 1 258 ? 23.592 39.885 -4.967  1.000 26.880 0  258  ASN A O   1 ? 
ATOM   2045 C CB  . ASN A 1 258 ? 24.351 42.059 -6.642  1.000 30.350 0  258  ASN A CB  1 ? 
ATOM   2046 C CG  . ASN A 1 258 ? 24.240 43.446 -7.238  1.000 36.670 0  258  ASN A CG  1 ? 
ATOM   2047 O OD1 . ASN A 1 258 ? 23.189 44.089 -7.124  1.000 33.890 0  258  ASN A OD1 1 ? 
ATOM   2048 N ND2 . ASN A 1 258 ? 25.322 43.942 -7.815  1.000 38.110 0  258  ASN A ND2 1 ? 
ATOM   2049 N N   . ASP A 1 259 ? 25.256 40.469 -3.573  1.000 22.570 0  259  ASP A N   1 ? 
ATOM   2050 C CA  . ASP A 1 259 ? 25.361 39.146 -2.993  1.000 23.180 0  259  ASP A CA  1 ? 
ATOM   2051 C C   . ASP A 1 259 ? 24.255 38.963 -1.945  1.000 21.230 0  259  ASP A C   1 ? 
ATOM   2052 O O   . ASP A 1 259 ? 23.693 39.926 -1.431  1.000 22.810 0  259  ASP A O   1 ? 
ATOM   2053 C CB  . ASP A 1 259 ? 26.724 38.922 -2.366  1.000 21.740 0  259  ASP A CB  1 ? 
ATOM   2054 C CG  . ASP A 1 259 ? 27.155 37.475 -2.165  1.000 19.090 0  259  ASP A CG  1 ? 
ATOM   2055 O OD1 . ASP A 1 259 ? 26.453 36.585 -2.695  1.000 19.420 0  259  ASP A OD1 1 ? 
ATOM   2056 O OD2 . ASP A 1 259 ? 28.199 37.274 -1.478  1.000 23.110 0  259  ASP A OD2 1 ? 
ATOM   2057 N N   . PHE A 1 260 ? 24.003 37.701 -1.613  1.000 21.750 0  260  PHE A N   1 ? 
ATOM   2058 C CA  . PHE A 1 260 ? 22.995 37.384 -0.604  1.000 19.240 0  260  PHE A CA  1 ? 
ATOM   2059 C C   . PHE A 1 260 ? 23.204 35.947 -0.161  1.000 18.170 0  260  PHE A C   1 ? 
ATOM   2060 O O   . PHE A 1 260 ? 23.894 35.154 -0.833  1.000 17.470 0  260  PHE A O   1 ? 
ATOM   2061 C CB  . PHE A 1 260 ? 21.570 37.556 -1.118  1.000 18.050 0  260  PHE A CB  1 ? 
ATOM   2062 C CG  . PHE A 1 260 ? 21.308 36.782 -2.390  1.000 19.650 0  260  PHE A CG  1 ? 
ATOM   2063 C CD1 . PHE A 1 260 ? 21.656 37.314 -3.622  1.000 21.300 0  260  PHE A CD1 1 ? 
ATOM   2064 C CD2 . PHE A 1 260 ? 20.650 35.554 -2.359  1.000 20.870 0  260  PHE A CD2 1 ? 
ATOM   2065 C CE1 . PHE A 1 260 ? 21.434 36.597 -4.783  1.000 22.110 0  260  PHE A CE1 1 ? 
ATOM   2066 C CE2 . PHE A 1 260 ? 20.386 34.869 -3.513  1.000 22.600 0  260  PHE A CE2 1 ? 
ATOM   2067 C CZ  . PHE A 1 260 ? 20.794 35.391 -4.730  1.000 25.590 0  260  PHE A CZ  1 ? 
ATOM   2068 N N   . PRO A 1 261 ? 22.680 35.558 1.029   1.000 15.600 0  261  PRO A N   1 ? 
ATOM   2069 C CA  . PRO A 1 261 ? 22.872 34.185 1.503   1.000 16.330 0  261  PRO A CA  1 ? 
ATOM   2070 C C   . PRO A 1 261 ? 22.131 33.176 0.649   1.000 16.510 0  261  PRO A C   1 ? 
ATOM   2071 O O   . PRO A 1 261 ? 20.989 33.478 0.279   1.000 16.800 0  261  PRO A O   1 ? 
ATOM   2072 C CB  . PRO A 1 261 ? 22.231 34.210 2.938   1.000 15.790 0  261  PRO A CB  1 ? 
ATOM   2073 C CG  . PRO A 1 261 ? 22.210 35.639 3.298   1.000 15.850 0  261  PRO A CG  1 ? 
ATOM   2074 C CD  . PRO A 1 261 ? 21.943 36.391 1.978   1.000 16.510 0  261  PRO A CD  1 ? 
ATOM   2075 N N   . VAL A 1 262 ? 22.737 31.981 0.384   1.000 16.500 0  262  VAL A N   1 ? 
ATOM   2076 C CA  . VAL A 1 262 ? 22.085 30.955 -0.417  1.000 17.150 0  262  VAL A CA  1 ? 
ATOM   2077 C C   . VAL A 1 262 ? 21.989 29.629 0.340   1.000 17.870 0  262  VAL A C   1 ? 
ATOM   2078 O O   . VAL A 1 262 ? 21.213 28.772 -0.043  1.000 19.330 0  262  VAL A O   1 ? 
ATOM   2079 C CB  . VAL A 1 262 ? 22.739 30.712 -1.801  1.000 19.650 0  262  VAL A CB  1 ? 
ATOM   2080 C CG1 . VAL A 1 262 ? 22.628 31.954 -2.684  1.000 21.170 0  262  VAL A CG1 1 ? 
ATOM   2081 C CG2 . VAL A 1 262 ? 24.174 30.210 -1.693  1.000 19.080 0  262  VAL A CG2 1 ? 
ATOM   2082 N N   . ALA A 1 263 ? 22.847 29.377 1.333   1.000 15.180 0  263  ALA A N   1 ? 
ATOM   2083 C CA  . ALA A 1 263 ? 22.838 28.075 1.990   1.000 16.180 0  263  ALA A CA  1 ? 
ATOM   2084 C C   . ALA A 1 263 ? 23.249 28.240 3.443   1.000 16.400 0  263  ALA A C   1 ? 
ATOM   2085 O O   . ALA A 1 263 ? 24.037 29.116 3.779   1.000 14.870 0  263  ALA A O   1 ? 
ATOM   2086 C CB  . ALA A 1 263 ? 23.784 27.126 1.313   1.000 17.530 0  263  ALA A CB  1 ? 
ATOM   2087 N N   . MET A 1 264 ? 22.667 27.395 4.287   1.000 15.920 0  264  MET A N   1 ? 
ATOM   2088 C CA  . MET A 1 264 ? 23.008 27.350 5.693   1.000 15.560 0  264  MET A CA  1 ? 
ATOM   2089 C C   . MET A 1 264 ? 22.991 25.906 6.143   1.000 16.470 0  264  MET A C   1 ? 
ATOM   2090 O O   . MET A 1 264 ? 22.068 25.141 5.831   1.000 17.580 0  264  MET A O   1 ? 
ATOM   2091 C CB  . MET A 1 264 ? 22.005 28.137 6.550   1.000 17.800 0  264  MET A CB  1 ? 
ATOM   2092 C CG  . MET A 1 264 ? 22.301 28.044 8.020   1.000 16.840 0  264  MET A CG  1 ? 
ATOM   2093 S SD  . MET A 1 264 ? 21.159 28.989 9.063   1.000 18.810 0  264  MET A SD  1 ? 
ATOM   2094 C CE  . MET A 1 264 ? 21.399 30.663 8.484   1.000 18.650 0  264  MET A CE  1 ? 
ATOM   2095 N N   . GLN A 1 265 ? 24.003 25.533 6.928   1.000 15.900 0  265  GLN A N   1 ? 
ATOM   2096 C CA  . GLN A 1 265 ? 23.994 24.263 7.616   1.000 15.350 0  265  GLN A CA  1 ? 
ATOM   2097 C C   . GLN A 1 265 ? 24.536 24.543 9.010   1.000 15.680 0  265  GLN A C   1 ? 
ATOM   2098 O O   . GLN A 1 265 ? 25.461 25.326 9.172   1.000 17.920 0  265  GLN A O   1 ? 
ATOM   2099 C CB  . GLN A 1 265 ? 24.814 23.164 6.938   1.000 18.800 0  265  GLN A CB  1 ? 
ATOM   2100 C CG  . GLN A 1 265 ? 24.322 22.783 5.536   1.000 20.320 0  265  GLN A CG  1 ? 
ATOM   2101 C CD  . GLN A 1 265 ? 22.958 22.112 5.421   1.000 22.760 0  265  GLN A CD  1 ? 
ATOM   2102 O OE1 . GLN A 1 265 ? 22.273 21.730 6.371   1.000 23.720 0  265  GLN A OE1 1 ? 
ATOM   2103 N NE2 . GLN A 1 265 ? 22.498 22.047 4.185   1.000 21.240 0  265  GLN A NE2 1 ? 
ATOM   2104 N N   . ILE A 1 266 ? 23.998 23.835 10.005  1.000 16.940 0  266  ILE A N   1 ? 
ATOM   2105 C CA  . ILE A 1 266 ? 24.420 24.010 11.377  1.000 15.510 0  266  ILE A CA  1 ? 
ATOM   2106 C C   . ILE A 1 266 ? 25.071 22.705 11.831  1.000 18.170 0  266  ILE A C   1 ? 
ATOM   2107 O O   . ILE A 1 266 ? 24.572 21.617 11.567  1.000 20.660 0  266  ILE A O   1 ? 
ATOM   2108 C CB  . ILE A 1 266 ? 23.196 24.414 12.236  1.000 17.180 0  266  ILE A CB  1 ? 
ATOM   2109 C CG1 . ILE A 1 266 ? 22.593 25.701 11.759  1.000 17.220 0  266  ILE A CG1 1 ? 
ATOM   2110 C CG2 . ILE A 1 266 ? 23.586 24.460 13.728  1.000 17.510 0  266  ILE A CG2 1 ? 
ATOM   2111 C CD1 . ILE A 1 266 ? 21.374 26.164 12.545  1.000 19.740 0  266  ILE A CD1 1 ? 
ATOM   2112 N N   . SER A 1 267 ? 26.251 22.814 12.428  1.000 17.120 0  267  SER A N   1 ? 
ATOM   2113 C CA  . SER A 1 267 ? 26.903 21.699 13.091  1.000 19.140 0  267  SER A CA  1 ? 
ATOM   2114 C C   . SER A 1 267 ? 26.405 21.638 14.530  1.000 20.280 0  267  SER A C   1 ? 
ATOM   2115 O O   . SER A 1 267 ? 26.642 22.551 15.300  1.000 20.170 0  267  SER A O   1 ? 
ATOM   2116 C CB  . SER A 1 267 ? 28.372 21.895 13.084  1.000 21.130 0  267  SER A CB  1 ? 
ATOM   2117 O OG  . SER A 1 267 ? 28.992 20.936 13.910  1.000 21.040 0  267  SER A OG  1 ? 
ATOM   2118 N N   . GLU A 1 268 ? 25.750 20.563 14.918  1.000 24.190 0  268  GLU A N   1 ? 
ATOM   2119 C CA  . GLU A 1 268 ? 25.394 20.423 16.324  1.000 25.940 0  268  GLU A CA  1 ? 
ATOM   2120 C C   . GLU A 1 268 ? 26.548 19.778 17.112  1.000 24.380 0  268  GLU A C   1 ? 
ATOM   2121 O O   . GLU A 1 268 ? 26.546 19.821 18.335  1.000 27.330 0  268  GLU A O   1 ? 
ATOM   2122 C CB  . GLU A 1 268 ? 24.034 19.738 16.494  1.000 27.710 0  268  GLU A CB  1 ? 
ATOM   2123 C CG  . GLU A 1 268 ? 22.838 20.604 16.068  1.000 28.870 0  268  GLU A CG  1 ? 
ATOM   2124 C CD  . GLU A 1 268 ? 21.505 19.854 16.100  1.000 30.990 0  268  GLU A CD  1 ? 
ATOM   2125 O OE1 . GLU A 1 268 ? 21.413 18.760 16.707  1.000 30.310 0  268  GLU A OE1 1 ? 
ATOM   2126 O OE2 . GLU A 1 268 ? 20.575 20.338 15.449  1.000 29.250 0  268  GLU A OE2 1 ? 
ATOM   2127 N N   . LYS A 1 269 ? 27.565 19.252 16.430  1.000 22.700 0  269  LYS A N   1 ? 
ATOM   2128 C CA  . LYS A 1 269 ? 28.776 18.843 17.115  1.000 23.340 0  269  LYS A CA  1 ? 
ATOM   2129 C C   . LYS A 1 269 ? 29.545 20.055 17.650  1.000 21.290 0  269  LYS A C   1 ? 
ATOM   2130 O O   . LYS A 1 269 ? 30.145 19.987 18.721  1.000 21.170 0  269  LYS A O   1 ? 
ATOM   2131 C CB  . LYS A 1 269 ? 29.689 18.025 16.188  1.000 27.310 0  269  LYS A CB  1 ? 
ATOM   2132 C CG  . LYS A 1 269 ? 30.892 17.388 16.881  1.000 33.010 0  269  LYS A CG  1 ? 
ATOM   2133 C CD  . LYS A 1 269 ? 31.843 16.708 15.896  1.000 40.580 0  269  LYS A CD  1 ? 
ATOM   2134 C CE  . LYS A 1 269 ? 32.680 15.598 16.483  1.000 51.270 0  269  LYS A CE  1 ? 
ATOM   2135 N NZ  . LYS A 1 269 ? 33.536 16.030 17.589  1.000 56.330 0  269  LYS A NZ  1 ? 
ATOM   2136 N N   . HIS A 1 270 ? 29.612 21.147 16.884  1.000 19.060 0  270  HIS A N   1 ? 
ATOM   2137 C CA  . HIS A 1 270 ? 30.391 22.311 17.280  1.000 20.760 0  270  HIS A CA  1 ? 
ATOM   2138 C C   . HIS A 1 270 ? 29.521 23.513 17.649  1.000 19.270 0  270  HIS A C   1 ? 
ATOM   2139 O O   . HIS A 1 270 ? 30.052 24.482 18.154  1.000 18.770 0  270  HIS A O   1 ? 
ATOM   2140 C CB  . HIS A 1 270 ? 31.405 22.660 16.189  1.000 20.970 0  270  HIS A CB  1 ? 
ATOM   2141 C CG  . HIS A 1 270 ? 32.335 21.547 15.879  1.000 24.860 0  270  HIS A CG  1 ? 
ATOM   2142 N ND1 . HIS A 1 270 ? 32.291 20.853 14.695  1.000 27.880 0  270  HIS A ND1 1 ? 
ATOM   2143 C CD2 . HIS A 1 270 ? 33.261 20.951 16.627  1.000 27.840 0  270  HIS A CD2 1 ? 
ATOM   2144 C CE1 . HIS A 1 270 ? 33.238 19.936 14.716  1.000 28.660 0  270  HIS A CE1 1 ? 
ATOM   2145 N NE2 . HIS A 1 270 ? 33.838 19.966 15.871  1.000 26.550 0  270  HIS A NE2 1 ? 
ATOM   2146 N N   . ASP A 1 271 ? 28.203 23.437 17.440  1.000 20.370 0  271  ASP A N   1 ? 
ATOM   2147 C CA  . ASP A 1 271 ? 27.286 24.549 17.677  1.000 18.860 0  271  ASP A CA  1 ? 
ATOM   2148 C C   . ASP A 1 271 ? 27.728 25.792 16.913  1.000 17.070 0  271  ASP A C   1 ? 
ATOM   2149 O O   . ASP A 1 271 ? 27.885 26.875 17.465  1.000 15.720 0  271  ASP A O   1 ? 
ATOM   2150 C CB  . ASP A 1 271 ? 27.011 24.779 19.151  1.000 21.150 0  271  ASP A CB  1 ? 
ATOM   2151 C CG  . ASP A 1 271 ? 26.378 23.587 19.845  1.000 21.620 0  271  ASP A CG  1 ? 
ATOM   2152 O OD1 . ASP A 1 271 ? 25.430 23.001 19.238  1.000 22.770 0  271  ASP A OD1 1 ? 
ATOM   2153 O OD2 . ASP A 1 271 ? 26.872 23.208 20.961  1.000 23.640 0  271  ASP A OD2 1 ? 
ATOM   2154 N N   . VAL A 1 272 ? 27.936 25.595 15.620  1.000 15.670 0  272  VAL A N   1 ? 
ATOM   2155 C CA  . VAL A 1 272 ? 28.315 26.654 14.707  1.000 15.010 0  272  VAL A CA  1 ? 
ATOM   2156 C C   . VAL A 1 272 ? 27.404 26.606 13.492  1.000 13.210 0  272  VAL A C   1 ? 
ATOM   2157 O O   . VAL A 1 272 ? 26.921 25.555 13.080  1.000 16.520 0  272  VAL A O   1 ? 
ATOM   2158 C CB  . VAL A 1 272 ? 29.788 26.604 14.283  1.000 18.060 0  272  VAL A CB  1 ? 
ATOM   2159 C CG1 . VAL A 1 272 ? 30.743 26.844 15.458  1.000 17.730 0  272  VAL A CG1 1 ? 
ATOM   2160 C CG2 . VAL A 1 272 ? 30.146 25.333 13.572  1.000 19.380 0  272  VAL A CG2 1 ? 
ATOM   2161 N N   . VAL A 1 273 ? 27.199 27.771 12.931  1.000 14.590 0  273  VAL A N   1 ? 
ATOM   2162 C CA  . VAL A 1 273 ? 26.421 27.941 11.723  1.000 14.380 0  273  VAL A CA  1 ? 
ATOM   2163 C C   . VAL A 1 273 ? 27.370 28.212 10.562  1.000 15.070 0  273  VAL A C   1 ? 
ATOM   2164 O O   . VAL A 1 273 ? 28.131 29.193 10.609  1.000 15.670 0  273  VAL A O   1 ? 
ATOM   2165 C CB  . VAL A 1 273 ? 25.514 29.162 11.894  1.000 15.460 0  273  VAL A CB  1 ? 
ATOM   2166 C CG1 . VAL A 1 273 ? 24.655 29.378 10.662  1.000 15.300 0  273  VAL A CG1 1 ? 
ATOM   2167 C CG2 . VAL A 1 273 ? 24.647 29.074 13.140  1.000 17.620 0  273  VAL A CG2 1 ? 
ATOM   2168 N N   . PHE A 1 274 ? 27.247 27.428 9.500   1.000 14.630 0  274  PHE A N   1 ? 
ATOM   2169 C CA  . PHE A 1 274 ? 27.905 27.737 8.243   1.000 14.650 0  274  PHE A CA  1 ? 
ATOM   2170 C C   . PHE A 1 274 ? 26.895 28.442 7.334   1.000 15.170 0  274  PHE A C   1 ? 
ATOM   2171 O O   . PHE A 1 274 ? 25.809 27.920 7.069   1.000 16.450 0  274  PHE A O   1 ? 
ATOM   2172 C CB  . PHE A 1 274 ? 28.397 26.482 7.534   1.000 15.590 0  274  PHE A CB  1 ? 
ATOM   2173 C CG  . PHE A 1 274 ? 29.369 25.617 8.326   1.000 16.860 0  274  PHE A CG  1 ? 
ATOM   2174 C CD1 . PHE A 1 274 ? 28.929 24.655 9.217   1.000 19.220 0  274  PHE A CD1 1 ? 
ATOM   2175 C CD2 . PHE A 1 274 ? 30.725 25.778 8.153   1.000 18.160 0  274  PHE A CD2 1 ? 
ATOM   2176 C CE1 . PHE A 1 274 ? 29.845 23.885 9.946   1.000 20.210 0  274  PHE A CE1 1 ? 
ATOM   2177 C CE2 . PHE A 1 274 ? 31.626 25.038 8.912   1.000 19.210 0  274  PHE A CE2 1 ? 
ATOM   2178 C CZ  . PHE A 1 274 ? 31.184 24.092 9.779   1.000 20.470 0  274  PHE A CZ  1 ? 
ATOM   2179 N N   . LEU A 1 275 ? 27.288 29.593 6.796   1.000 13.990 0  275  LEU A N   1 ? 
ATOM   2180 C CA  . LEU A 1 275 ? 26.507 30.338 5.835   1.000 14.770 0  275  LEU A CA  1 ? 
ATOM   2181 C C   . LEU A 1 275 ? 27.339 30.490 4.559   1.000 16.340 0  275  LEU A C   1 ? 
ATOM   2182 O O   . LEU A 1 275 ? 28.458 30.980 4.618   1.000 17.010 0  275  LEU A O   1 ? 
ATOM   2183 C CB  . LEU A 1 275 ? 26.174 31.723 6.385   1.000 16.270 0  275  LEU A CB  1 ? 
ATOM   2184 C CG  . LEU A 1 275 ? 25.130 32.523 5.608   1.000 18.790 0  275  LEU A CG  1 ? 
ATOM   2185 C CD1 . LEU A 1 275 ? 23.765 31.822 5.687   1.000 23.170 0  275  LEU A CD1 1 ? 
ATOM   2186 C CD2 . LEU A 1 275 ? 25.029 33.913 6.210   1.000 20.040 0  275  LEU A CD2 1 ? 
ATOM   2187 N N   . ILE A 1 276 ? 26.753 30.131 3.432   1.000 15.320 0  276  ILE A N   1 ? 
ATOM   2188 C CA  . ILE A 1 276 ? 27.382 30.408 2.154   1.000 15.530 0  276  ILE A CA  1 ? 
ATOM   2189 C C   . ILE A 1 276 ? 26.542 31.423 1.367   1.000 17.430 0  276  ILE A C   1 ? 
ATOM   2190 O O   . ILE A 1 276 ? 25.310 31.345 1.345   1.000 17.040 0  276  ILE A O   1 ? 
ATOM   2191 C CB  . ILE A 1 276 ? 27.561 29.058 1.426   1.000 18.500 0  276  ILE A CB  1 ? 
ATOM   2192 C CG1 . ILE A 1 276 ? 28.608 28.166 2.131   1.000 21.200 0  276  ILE A CG1 1 ? 
ATOM   2193 C CG2 . ILE A 1 276 ? 27.978 29.325 -0.028  1.000 21.210 0  276  ILE A CG2 1 ? 
ATOM   2194 C CD1 . ILE A 1 276 ? 28.852 26.847 1.441   1.000 23.450 0  276  ILE A CD1 1 ? 
ATOM   2195 N N   . THR A 1 277 ? 27.221 32.382 0.725   1.000 17.250 0  277  THR A N   1 ? 
ATOM   2196 C CA  . THR A 1 277 ? 26.579 33.392 -0.121  1.000 19.230 0  277  THR A CA  1 ? 
ATOM   2197 C C   . THR A 1 277 ? 26.593 32.941 -1.580  1.000 19.600 0  277  THR A C   1 ? 
ATOM   2198 O O   . THR A 1 277 ? 27.383 32.097 -2.011  1.000 20.020 0  277  THR A O   1 ? 
ATOM   2199 C CB  . THR A 1 277 ? 27.220 34.771 0.029   1.000 19.980 0  277  THR A CB  1 ? 
ATOM   2200 O OG1 . THR A 1 277 ? 28.462 34.754 -0.673  1.000 19.960 0  277  THR A OG1 1 ? 
ATOM   2201 C CG2 . THR A 1 277 ? 27.365 35.177 1.486   1.000 19.170 0  277  THR A CG2 1 ? 
ATOM   2202 N N   . LYS A 1 278 ? 25.696 33.560 -2.341  1.000 21.050 0  278  LYS A N   1 ? 
ATOM   2203 C CA  . LYS A 1 278 ? 25.536 33.326 -3.758  1.000 22.540 0  278  LYS A CA  1 ? 
ATOM   2204 C C   . LYS A 1 278 ? 26.849 33.399 -4.519  1.000 22.470 0  278  LYS A C   1 ? 
ATOM   2205 O O   . LYS A 1 278 ? 27.059 32.578 -5.405  1.000 25.790 0  278  LYS A O   1 ? 
ATOM   2206 C CB  . LYS A 1 278 ? 24.661 34.438 -4.332  1.000 23.180 0  278  LYS A CB  1 ? 
ATOM   2207 C CG  . LYS A 1 278 ? 24.297 34.329 -5.814  1.000 26.350 0  278  LYS A CG  1 ? 
ATOM   2208 C CD  . LYS A 1 278 ? 23.547 33.038 -6.101  1.000 27.730 0  278  LYS A CD  1 ? 
ATOM   2209 C CE  . LYS A 1 278 ? 23.103 32.952 -7.532  1.000 32.040 0  278  LYS A CE  1 ? 
ATOM   2210 N NZ  . LYS A 1 278 ? 22.101 31.897 -7.663  1.000 33.560 0  278  LYS A NZ  1 ? 
ATOM   2211 N N   . TYR A 1 279 ? 27.641 34.431 -4.251  1.000 22.140 0  279  TYR A N   1 ? 
ATOM   2212 C CA  . TYR A 1 279 ? 28.848 34.676 -5.037  1.000 24.300 0  279  TYR A CA  1 ? 
ATOM   2213 C C   . TYR A 1 279 ? 30.110 34.168 -4.325  1.000 27.230 0  279  TYR A C   1 ? 
ATOM   2214 O O   . TYR A 1 279 ? 31.209 34.656 -4.611  1.000 28.970 0  279  TYR A O   1 ? 
ATOM   2215 C CB  . TYR A 1 279 ? 28.917 36.152 -5.416  1.000 23.970 0  279  TYR A CB  1 ? 
ATOM   2216 C CG  . TYR A 1 279 ? 27.801 36.411 -6.419  1.000 27.090 0  279  TYR A CG  1 ? 
ATOM   2217 C CD1 . TYR A 1 279 ? 27.866 35.871 -7.702  1.000 28.950 0  279  TYR A CD1 1 ? 
ATOM   2218 C CD2 . TYR A 1 279 ? 26.668 37.115 -6.063  1.000 28.680 0  279  TYR A CD2 1 ? 
ATOM   2219 C CE1 . TYR A 1 279 ? 26.852 36.073 -8.617  1.000 29.930 0  279  TYR A CE1 1 ? 
ATOM   2220 C CE2 . TYR A 1 279 ? 25.629 37.303 -6.965  1.000 34.120 0  279  TYR A CE2 1 ? 
ATOM   2221 C CZ  . TYR A 1 279 ? 25.712 36.751 -8.236  1.000 30.890 0  279  TYR A CZ  1 ? 
ATOM   2222 O OH  . TYR A 1 279 ? 24.696 36.947 -9.129  1.000 37.370 0  279  TYR A OH  1 ? 
ATOM   2223 N N   . GLY A 1 280 ? 29.941 33.244 -3.362  1.000 27.230 0  280  GLY A N   1 ? 
ATOM   2224 C CA  . GLY A 1 280 ? 30.999 32.314 -2.991  1.000 27.140 0  280  GLY A CA  1 ? 
ATOM   2225 C C   . GLY A 1 280 ? 31.675 32.614 -1.658  1.000 26.510 0  280  GLY A C   1 ? 
ATOM   2226 O O   . GLY A 1 280 ? 32.737 32.049 -1.379  1.000 27.390 0  280  GLY A O   1 ? 
ATOM   2227 N N   . TYR A 1 281 ? 31.075 33.455 -0.805  1.000 21.780 0  281  TYR A N   1 ? 
ATOM   2228 C CA  . TYR A 1 281 ? 31.629 33.684 0.511   1.000 21.100 0  281  TYR A CA  1 ? 
ATOM   2229 C C   . TYR A 1 281 ? 31.141 32.600 1.487   1.000 22.630 0  281  TYR A C   1 ? 
ATOM   2230 O O   . TYR A 1 281 ? 29.983 32.159 1.437   1.000 19.820 0  281  TYR A O   1 ? 
ATOM   2231 C CB  . TYR A 1 281 ? 31.309 35.103 0.963   1.000 24.310 0  281  TYR A CB  1 ? 
ATOM   2232 C CG  . TYR A 1 281 ? 31.905 36.229 0.114   1.000 27.390 0  281  TYR A CG  1 ? 
ATOM   2233 C CD1 . TYR A 1 281 ? 31.400 36.531 -1.146  1.000 30.560 0  281  TYR A CD1 1 ? 
ATOM   2234 C CD2 . TYR A 1 281 ? 32.967 36.982 0.578   1.000 28.760 0  281  TYR A CD2 1 ? 
ATOM   2235 C CE1 . TYR A 1 281 ? 31.912 37.585 -1.892  1.000 32.480 0  281  TYR A CE1 1 ? 
ATOM   2236 C CE2 . TYR A 1 281 ? 33.514 38.009 -0.180  1.000 31.080 0  281  TYR A CE2 1 ? 
ATOM   2237 C CZ  . TYR A 1 281 ? 32.971 38.327 -1.406  1.000 33.450 0  281  TYR A CZ  1 ? 
ATOM   2238 O OH  . TYR A 1 281 ? 33.465 39.373 -2.145  1.000 38.000 0  281  TYR A OH  1 ? 
ATOM   2239 N N   . ILE A 1 282 ? 32.005 32.266 2.453   1.000 19.450 0  282  ILE A N   1 ? 
ATOM   2240 C CA  . ILE A 1 282 ? 31.669 31.378 3.549   1.000 20.920 0  282  ILE A CA  1 ? 
ATOM   2241 C C   . ILE A 1 282 ? 31.763 32.225 4.820   1.000 20.490 0  282  ILE A C   1 ? 
ATOM   2242 O O   . ILE A 1 282 ? 32.731 32.960 5.016   1.000 19.730 0  282  ILE A O   1 ? 
ATOM   2243 C CB  . ILE A 1 282 ? 32.570 30.136 3.635   1.000 23.480 0  282  ILE A CB  1 ? 
ATOM   2244 C CG1 . ILE A 1 282 ? 32.245 29.261 4.838   1.000 31.330 0  282  ILE A CG1 1 ? 
ATOM   2245 C CG2 . ILE A 1 282 ? 34.057 30.479 3.629   1.000 28.600 0  282  ILE A CG2 1 ? 
ATOM   2246 C CD1 . ILE A 1 282 ? 31.221 28.195 4.580   1.000 32.170 0  282  ILE A CD1 1 ? 
ATOM   2247 N N   . HIS A 1 283 ? 30.774 32.071 5.705   1.000 18.680 0  283  HIS A N   1 ? 
ATOM   2248 C CA  . HIS A 1 283 ? 30.802 32.711 7.005   1.000 17.130 0  283  HIS A CA  1 ? 
ATOM   2249 C C   . HIS A 1 283 ? 30.587 31.614 8.050   1.000 18.160 0  283  HIS A C   1 ? 
ATOM   2250 O O   . HIS A 1 283 ? 29.866 30.627 7.809   1.000 16.380 0  283  HIS A O   1 ? 
ATOM   2251 C CB  . HIS A 1 283 ? 29.692 33.739 7.168   1.000 18.270 0  283  HIS A CB  1 ? 
ATOM   2252 C CG  . HIS A 1 283 ? 29.671 34.888 6.210   1.000 20.670 0  283  HIS A CG  1 ? 
ATOM   2253 N ND1 . HIS A 1 283 ? 28.870 35.952 6.523   1.000 24.370 0  283  HIS A ND1 1 ? 
ATOM   2254 C CD2 . HIS A 1 283 ? 30.140 35.148 5.002   1.000 23.000 0  283  HIS A CD2 1 ? 
ATOM   2255 C CE1 . HIS A 1 283 ? 28.913 36.849 5.548   1.000 26.690 0  283  HIS A CE1 1 ? 
ATOM   2256 N NE2 . HIS A 1 283 ? 29.667 36.369 4.600   1.000 23.820 0  283  HIS A NE2 1 ? 
ATOM   2257 N N   . LEU A 1 284 ? 31.243 31.760 9.201   1.000 17.020 0  284  LEU A N   1 ? 
ATOM   2258 C CA  . LEU A 1 284 ? 31.036 30.880 10.345  1.000 17.960 0  284  LEU A CA  1 ? 
ATOM   2259 C C   . LEU A 1 284 ? 30.573 31.722 11.532  1.000 18.150 0  284  LEU A C   1 ? 
ATOM   2260 O O   . LEU A 1 284 ? 31.204 32.724 11.846  1.000 16.990 0  284  LEU A O   1 ? 
ATOM   2261 C CB  . LEU A 1 284 ? 32.332 30.169 10.686  1.000 21.250 0  284  LEU A CB  1 ? 
ATOM   2262 C CG  . LEU A 1 284 ? 32.230 28.983 11.638  1.000 23.520 0  284  LEU A CG  1 ? 
ATOM   2263 C CD1 . LEU A 1 284 ? 31.487 27.798 11.006  1.000 25.250 0  284  LEU A CD1 1 ? 
ATOM   2264 C CD2 . LEU A 1 284 ? 33.624 28.555 12.085  1.000 27.140 0  284  LEU A CD2 1 ? 
ATOM   2265 N N   . TYR A 1 285 ? 29.480 31.293 12.167  1.000 15.420 0  285  TYR A N   1 ? 
ATOM   2266 C CA  . TYR A 1 285 ? 28.936 31.989 13.334  1.000 15.540 0  285  TYR A CA  1 ? 
ATOM   2267 C C   . TYR A 1 285 ? 28.768 31.009 14.482  1.000 17.510 0  285  TYR A C   1 ? 
ATOM   2268 O O   . TYR A 1 285 ? 28.496 29.829 14.304  1.000 14.700 0  285  TYR A O   1 ? 
ATOM   2269 C CB  . TYR A 1 285 ? 27.572 32.661 13.106  1.000 17.810 0  285  TYR A CB  1 ? 
ATOM   2270 C CG  . TYR A 1 285 ? 27.524 33.706 12.022  1.000 15.840 0  285  TYR A CG  1 ? 
ATOM   2271 C CD1 . TYR A 1 285 ? 27.356 33.332 10.701  1.000 17.150 0  285  TYR A CD1 1 ? 
ATOM   2272 C CD2 . TYR A 1 285 ? 27.692 35.055 12.289  1.000 17.730 0  285  TYR A CD2 1 ? 
ATOM   2273 C CE1 . TYR A 1 285 ? 27.340 34.272 9.679   1.000 18.100 0  285  TYR A CE1 1 ? 
ATOM   2274 C CE2 . TYR A 1 285 ? 27.675 36.011 11.282  1.000 18.000 0  285  TYR A CE2 1 ? 
ATOM   2275 C CZ  . TYR A 1 285 ? 27.560 35.610 9.972   1.000 19.290 0  285  TYR A CZ  1 ? 
ATOM   2276 O OH  . TYR A 1 285 ? 27.580 36.511 8.961   1.000 21.280 0  285  TYR A OH  1 ? 
ATOM   2277 N N   . ASP A 1 286 ? 28.923 31.512 15.710  1.000 17.040 0  286  ASP A N   1 ? 
ATOM   2278 C CA  . ASP A 1 286 ? 28.620 30.696 16.858  1.000 15.450 0  286  ASP A CA  1 ? 
ATOM   2279 C C   . ASP A 1 286 ? 27.097 30.631 17.007  1.000 15.280 0  286  ASP A C   1 ? 
ATOM   2280 O O   . ASP A 1 286 ? 26.462 31.659 16.920  1.000 16.940 0  286  ASP A O   1 ? 
ATOM   2281 C CB  . ASP A 1 286 ? 29.155 31.397 18.093  1.000 18.490 0  286  ASP A CB  1 ? 
ATOM   2282 C CG  . ASP A 1 286 ? 28.671 30.793 19.393  1.000 22.500 0  286  ASP A CG  1 ? 
ATOM   2283 O OD1 . ASP A 1 286 ? 28.576 29.569 19.415  1.000 19.920 0  286  ASP A OD1 1 ? 
ATOM   2284 O OD2 . ASP A 1 286 ? 28.472 31.577 20.370  1.000 23.210 0  286  ASP A OD2 1 ? 
ATOM   2285 N N   . LEU A 1 287 ? 26.526 29.445 17.188  1.000 14.720 0  287  LEU A N   1 ? 
ATOM   2286 C CA  . LEU A 1 287 ? 25.065 29.274 17.246  1.000 16.430 0  287  LEU A CA  1 ? 
ATOM   2287 C C   . LEU A 1 287 ? 24.501 29.913 18.511  1.000 18.160 0  287  LEU A C   1 ? 
ATOM   2288 O O   . LEU A 1 287 ? 23.407 30.459 18.486  1.000 19.770 0  287  LEU A O   1 ? 
ATOM   2289 C CB  . LEU A 1 287 ? 24.756 27.782 17.207  1.000 16.480 0  287  LEU A CB  1 ? 
ATOM   2290 C CG  . LEU A 1 287 ? 23.292 27.364 17.340  1.000 17.830 0  287  LEU A CG  1 ? 
ATOM   2291 C CD1 . LEU A 1 287 ? 22.437 27.980 16.220  1.000 18.110 0  287  LEU A CD1 1 ? 
ATOM   2292 C CD2 . LEU A 1 287 ? 23.231 25.837 17.436  1.000 16.720 0  287  LEU A CD2 1 ? 
ATOM   2293 N N   . GLU A 1 288 ? 25.278 29.893 19.592  1.000 18.480 0  288  GLU A N   1 ? 
ATOM   2294 C CA  . GLU A 1 288 ? 24.779 30.343 20.887  1.000 20.230 0  288  GLU A CA  1 ? 
ATOM   2295 C C   . GLU A 1 288 ? 24.647 31.859 20.944  1.000 22.040 0  288  GLU A C   1 ? 
ATOM   2296 O O   . GLU A 1 288 ? 23.631 32.385 21.397  1.000 22.910 0  288  GLU A O   1 ? 
ATOM   2297 C CB  . GLU A 1 288 ? 25.709 29.813 21.962  1.000 20.290 0  288  GLU A CB  1 ? 
ATOM   2298 C CG  . GLU A 1 288 ? 25.284 30.242 23.360  1.000 23.790 0  288  GLU A CG  1 ? 
ATOM   2299 C CD  . GLU A 1 288 ? 26.027 29.479 24.419  1.000 27.210 0  288  GLU A CD  1 ? 
ATOM   2300 O OE1 . GLU A 1 288 ? 27.179 28.979 24.225  1.000 28.680 0  288  GLU A OE1 1 ? 
ATOM   2301 O OE2 . GLU A 1 288 ? 25.414 29.409 25.499  1.000 33.580 0  288  GLU A OE2 1 ? 
ATOM   2302 N N   . THR A 1 289 ? 25.681 32.583 20.469  1.000 21.890 0  289  THR A N   1 ? 
ATOM   2303 C CA  . THR A 1 289 ? 25.732 34.038 20.545  1.000 21.560 0  289  THR A CA  1 ? 
ATOM   2304 C C   . THR A 1 289 ? 25.530 34.731 19.222  1.000 23.580 0  289  THR A C   1 ? 
ATOM   2305 O O   . THR A 1 289 ? 25.248 35.923 19.225  1.000 24.290 0  289  THR A O   1 ? 
ATOM   2306 C CB  . THR A 1 289 ? 27.069 34.480 21.126  1.000 24.400 0  289  THR A CB  1 ? 
ATOM   2307 O OG1 . THR A 1 289 ? 28.102 34.048 20.233  1.000 21.350 0  289  THR A OG1 1 ? 
ATOM   2308 C CG2 . THR A 1 289 ? 27.257 33.919 22.521  1.000 25.860 0  289  THR A CG2 1 ? 
ATOM   2309 N N   . GLY A 1 290 ? 25.700 34.025 18.091  1.000 19.220 0  290  GLY A N   1 ? 
ATOM   2310 C CA  . GLY A 1 290 ? 25.693 34.704 16.824  1.000 20.570 0  290  GLY A CA  1 ? 
ATOM   2311 C C   . GLY A 1 290 ? 27.009 35.401 16.484  1.000 19.090 0  290  GLY A C   1 ? 
ATOM   2312 O O   . GLY A 1 290 ? 27.098 36.003 15.429  1.000 19.780 0  290  GLY A O   1 ? 
ATOM   2313 N N   . THR A 1 291 ? 28.021 35.285 17.337  1.000 18.490 0  291  THR A N   1 ? 
ATOM   2314 C CA  . THR A 1 291 ? 29.308 35.914 17.045  1.000 18.050 0  291  THR A CA  1 ? 
ATOM   2315 C C   . THR A 1 291 ? 29.860 35.376 15.738  1.000 18.170 0  291  THR A C   1 ? 
ATOM   2316 O O   . THR A 1 291 ? 29.958 34.170 15.581  1.000 17.900 0  291  THR A O   1 ? 
ATOM   2317 C CB  . THR A 1 291 ? 30.310 35.651 18.168  1.000 19.540 0  291  THR A CB  1 ? 
ATOM   2318 O OG1 . THR A 1 291 ? 29.756 36.137 19.386  1.000 20.630 0  291  THR A OG1 1 ? 
ATOM   2319 C CG2 . THR A 1 291 ? 31.631 36.352 17.910  1.000 19.220 0  291  THR A CG2 1 ? 
ATOM   2320 N N   . CYS A 1 292 ? 30.333 36.285 14.868  1.000 19.240 0  292  CYS A N   1 ? 
ATOM   2321 C CA  . CYS A 1 292 ? 30.965 35.918 13.615  1.000 18.840 0  292  CYS A CA  1 ? 
ATOM   2322 C C   . CYS A 1 292 ? 32.395 35.478 13.901  1.000 21.400 0  292  CYS A C   1 ? 
ATOM   2323 O O   . CYS A 1 292 ? 33.202 36.284 14.369  1.000 24.210 0  292  CYS A O   1 ? 
ATOM   2324 C CB  . CYS A 1 292 ? 30.964 37.075 12.626  1.000 21.950 0  292  CYS A CB  1 ? 
ATOM   2325 S SG  . CYS A 1 292 ? 31.491 36.535 10.977  1.000 25.630 0  292  CYS A SG  1 ? 
ATOM   2326 N N   . ILE A 1 293 ? 32.688 34.207 13.628  1.000 18.920 0  293  ILE A N   1 ? 
ATOM   2327 C CA  . ILE A 1 293 ? 34.001 33.658 13.861  1.000 19.250 0  293  ILE A CA  1 ? 
ATOM   2328 C C   . ILE A 1 293 ? 34.907 33.897 12.650  1.000 21.410 0  293  ILE A C   1 ? 
ATOM   2329 O O   . ILE A 1 293 ? 36.113 34.106 12.813  1.000 22.550 0  293  ILE A O   1 ? 
ATOM   2330 C CB  . ILE A 1 293 ? 33.875 32.169 14.216  1.000 18.730 0  293  ILE A CB  1 ? 
ATOM   2331 C CG1 . ILE A 1 293 ? 33.114 31.961 15.572  1.000 19.490 0  293  ILE A CG1 1 ? 
ATOM   2332 C CG2 . ILE A 1 293 ? 35.225 31.469 14.234  1.000 20.260 0  293  ILE A CG2 1 ? 
ATOM   2333 C CD1 . ILE A 1 293 ? 32.542 30.580 15.704  1.000 21.860 0  293  ILE A CD1 1 ? 
ATOM   2334 N N   . TYR A 1 294 ? 34.366 33.817 11.437  1.000 19.250 0  294  TYR A N   1 ? 
ATOM   2335 C CA  . TYR A 1 294 ? 35.239 33.719 10.268  1.000 20.510 0  294  TYR A CA  1 ? 
ATOM   2336 C C   . TYR A 1 294 ? 34.456 34.084 9.018   1.000 21.970 0  294  TYR A C   1 ? 
ATOM   2337 O O   . TYR A 1 294 ? 33.265 33.767 8.908   1.000 18.640 0  294  TYR A O   1 ? 
ATOM   2338 C CB  . TYR A 1 294 ? 35.802 32.308 10.141  1.000 21.280 0  294  TYR A CB  1 ? 
ATOM   2339 C CG  . TYR A 1 294 ? 36.849 32.210 9.026   1.000 23.140 0  294  TYR A CG  1 ? 
ATOM   2340 C CD1 . TYR A 1 294 ? 38.063 32.858 9.150   1.000 27.570 0  294  TYR A CD1 1 ? 
ATOM   2341 C CD2 . TYR A 1 294 ? 36.572 31.578 7.816   1.000 27.220 0  294  TYR A CD2 1 ? 
ATOM   2342 C CE1 . TYR A 1 294 ? 39.021 32.825 8.137   1.000 28.450 0  294  TYR A CE1 1 ? 
ATOM   2343 C CE2 . TYR A 1 294 ? 37.531 31.516 6.802   1.000 27.810 0  294  TYR A CE2 1 ? 
ATOM   2344 C CZ  . TYR A 1 294 ? 38.753 32.142 6.966   1.000 31.360 0  294  TYR A CZ  1 ? 
ATOM   2345 O OH  . TYR A 1 294 ? 39.692 32.107 5.965   1.000 35.990 0  294  TYR A OH  1 ? 
ATOM   2346 N N   . MET A 1 295 ? 35.076 34.852 8.119   1.000 21.460 0  295  MET A N   1 ? 
ATOM   2347 C CA  . MET A 1 295 ? 34.506 35.011 6.794   1.000 22.140 0  295  MET A CA  1 ? 
ATOM   2348 C C   . MET A 1 295 ? 35.628 34.893 5.766   1.000 25.480 0  295  MET A C   1 ? 
ATOM   2349 O O   . MET A 1 295 ? 36.738 35.373 6.025   1.000 25.570 0  295  MET A O   1 ? 
ATOM   2350 C CB  . MET A 1 295 ? 33.867 36.373 6.607   1.000 23.000 0  295  MET A CB  1 ? 
ATOM   2351 C CG  . MET A 1 295 ? 32.782 36.651 7.593   1.000 26.740 0  295  MET A CG  1 ? 
ATOM   2352 S SD  . MET A 1 295 ? 31.943 38.188 7.199   1.000 29.370 0  295  MET A SD  1 ? 
ATOM   2353 C CE  . MET A 1 295 ? 33.068 39.289 8.072   1.000 31.050 0  295  MET A CE  1 ? 
ATOM   2354 N N   . ASN A 1 296 ? 35.355 34.222 4.653   1.000 25.260 0  296  ASN A N   1 ? 
ATOM   2355 C CA  . ASN A 1 296 ? 36.305 34.253 3.544   1.000 31.380 0  296  ASN A CA  1 ? 
ATOM   2356 C C   . ASN A 1 296 ? 35.591 33.964 2.231   1.000 34.640 0  296  ASN A C   1 ? 
ATOM   2357 O O   . ASN A 1 296 ? 34.484 33.428 2.203   1.000 30.930 0  296  ASN A O   1 ? 
ATOM   2358 C CB  . ASN A 1 296 ? 37.433 33.252 3.754   1.000 33.830 0  296  ASN A CB  1 ? 
ATOM   2359 C CG  . ASN A 1 296 ? 38.638 33.550 2.890   1.000 38.060 0  296  ASN A CG  1 ? 
ATOM   2360 O OD1 . ASN A 1 296 ? 38.833 34.679 2.434   1.000 35.380 0  296  ASN A OD1 1 ? 
ATOM   2361 N ND2 . ASN A 1 296 ? 39.459 32.544 2.672   1.000 44.150 0  296  ASN A ND2 1 ? 
ATOM   2362 N N   . ARG A 1 297 ? 36.238 34.348 1.131   1.000 27.780 0  297  ARG A N   1 ? 
ATOM   2363 C CA  . ARG A 1 297 ? 35.699 34.067 -0.172  1.000 29.640 0  297  ARG A CA  1 ? 
ATOM   2364 C C   . ARG A 1 297 ? 36.272 32.728 -0.586  1.000 29.830 0  297  ARG A C   1 ? 
ATOM   2365 O O   . ARG A 1 297 ? 37.479 32.563 -0.627  1.000 33.900 0  297  ARG A O   1 ? 
ATOM   2366 C CB  . ARG A 1 297 ? 36.017 35.208 -1.153  1.000 33.920 0  297  ARG A CB  1 ? 
ATOM   2367 C CG  . ARG A 1 297 ? 35.125 35.084 -2.379  1.000 39.170 0  297  ARG A CG  1 ? 
ATOM   2368 C CD  . ARG A 1 297 ? 35.056 36.342 -3.215  1.000 44.610 0  297  ARG A CD  1 ? 
ATOM   2369 N NE  . ARG A 1 297 ? 34.083 36.117 -4.285  1.000 44.010 0  297  ARG A NE  1 ? 
ATOM   2370 C CZ  . ARG A 1 297 ? 33.896 36.931 -5.323  1.000 45.390 0  297  ARG A CZ  1 ? 
ATOM   2371 N NH1 . ARG A 1 297 ? 34.712 37.966 -5.523  1.000 48.380 0  297  ARG A NH1 1 ? 
ATOM   2372 N NH2 . ARG A 1 297 ? 32.921 36.668 -6.173  1.000 43.950 0  297  ARG A NH2 1 ? 
ATOM   2373 N N   . ILE A 1 298 ? 35.432 31.733 -0.815  1.000 28.220 0  298  ILE A N   1 ? 
ATOM   2374 C CA  . ILE A 1 298 ? 35.969 30.484 -1.310  1.000 33.690 0  298  ILE A CA  1 ? 
ATOM   2375 C C   . ILE A 1 298 ? 36.533 30.778 -2.699  1.000 37.440 0  298  ILE A C   1 ? 
ATOM   2376 O O   . ILE A 1 298 ? 37.696 30.501 -2.985  1.000 38.040 0  298  ILE A O   1 ? 
ATOM   2377 C CB  . ILE A 1 298 ? 34.903 29.385 -1.399  1.000 36.360 0  298  ILE A CB  1 ? 
ATOM   2378 C CG1 . ILE A 1 298 ? 34.491 28.917 -0.025  1.000 40.650 0  298  ILE A CG1 1 ? 
ATOM   2379 C CG2 . ILE A 1 298 ? 35.409 28.236 -2.277  1.000 38.950 0  298  ILE A CG2 1 ? 
ATOM   2380 C CD1 . ILE A 1 298 ? 33.141 28.228 0.022   1.000 34.930 0  298  ILE A CD1 1 ? 
ATOM   2381 N N   . SER A 1 299 ? 35.653 31.322 -3.559  1.000 36.520 0  299  SER A N   1 ? 
ATOM   2382 C CA  . SER A 1 299 ? 35.969 31.629 -4.950  1.000 42.000 0  299  SER A CA  1 ? 
ATOM   2383 C C   . SER A 1 299 ? 34.904 32.552 -5.554  1.000 44.300 0  299  SER A C   1 ? 
ATOM   2384 O O   . SER A 1 299 ? 34.041 33.078 -4.851  1.000 47.310 0  299  SER A O   1 ? 
ATOM   2385 C CB  . SER A 1 299 ? 36.036 30.355 -5.769  1.000 46.150 0  299  SER A CB  1 ? 
ATOM   2386 O OG  . SER A 1 299 ? 34.716 29.957 -6.122  1.000 38.790 0  299  SER A OG  1 ? 
ATOM   2387 N N   . GLY A 1 300 ? 34.943 32.677 -6.890  1.000 44.740 0  300  GLY A N   1 ? 
ATOM   2388 C CA  . GLY A 1 300 ? 33.940 33.420 -7.633  1.000 46.600 0  300  GLY A CA  1 ? 
ATOM   2389 C C   . GLY A 1 300 ? 32.726 32.572 -8.036  1.000 45.700 0  300  GLY A C   1 ? 
ATOM   2390 O O   . GLY A 1 300 ? 31.713 33.144 -8.431  1.000 48.590 0  300  GLY A O   1 ? 
ATOM   2391 N N   . GLU A 1 301 ? 32.800 31.239 -7.878  1.000 41.210 0  301  GLU A N   1 ? 
ATOM   2392 C CA  . GLU A 1 301 ? 31.790 30.321 -8.401  1.000 43.280 0  301  GLU A CA  1 ? 
ATOM   2393 C C   . GLU A 1 301 ? 30.576 30.149 -7.464  1.000 38.310 0  301  GLU A C   1 ? 
ATOM   2394 O O   . GLU A 1 301 ? 30.720 30.085 -6.249  1.000 41.920 0  301  GLU A O   1 ? 
ATOM   2395 C CB  . GLU A 1 301 ? 32.478 28.981 -8.652  1.000 46.580 0  301  GLU A CB  1 ? 
ATOM   2396 C CG  . GLU A 1 301 ? 31.768 28.190 -9.750  1.000 46.970 0  301  GLU A CG  1 ? 
ATOM   2397 C CD  . GLU A 1 301 ? 32.311 28.443 -11.143 1.000 41.580 0  301  GLU A CD  1 ? 
ATOM   2398 O OE1 . GLU A 1 301 ? 31.583 28.937 -12.048 1.000 48.230 0  301  GLU A OE1 1 ? 
ATOM   2399 O OE2 . GLU A 1 301 ? 33.509 28.083 -11.304 1.000 40.670 0  301  GLU A OE2 1 ? 
ATOM   2400 N N   . THR A 1 302 ? 29.351 30.133 -8.015  1.000 31.380 0  302  THR A N   1 ? 
ATOM   2401 C CA  . THR A 1 302 ? 28.163 29.936 -7.188  1.000 33.930 0  302  THR A CA  1 ? 
ATOM   2402 C C   . THR A 1 302 ? 28.052 28.470 -6.746  1.000 31.970 0  302  THR A C   1 ? 
ATOM   2403 O O   . THR A 1 302 ? 28.161 27.561 -7.575  1.000 26.160 0  302  THR A O   1 ? 
ATOM   2404 C CB  . THR A 1 302 ? 26.893 30.384 -7.910  1.000 35.120 0  302  THR A CB  1 ? 
ATOM   2405 O OG1 . THR A 1 302 ? 27.088 31.779 -8.146  1.000 35.910 0  302  THR A OG1 1 ? 
ATOM   2406 C CG2 . THR A 1 302 ? 25.662 30.150 -7.051  1.000 37.270 0  302  THR A CG2 1 ? 
ATOM   2407 N N   . ILE A 1 303 ? 27.930 28.263 -5.422  1.000 30.000 0  303  ILE A N   1 ? 
ATOM   2408 C CA  . ILE A 1 303 ? 27.597 26.978 -4.825  1.000 29.780 0  303  ILE A CA  1 ? 
ATOM   2409 C C   . ILE A 1 303 ? 26.083 26.950 -4.744  1.000 31.160 0  303  ILE A C   1 ? 
ATOM   2410 O O   . ILE A 1 303 ? 25.481 27.809 -4.104  1.000 34.720 0  303  ILE A O   1 ? 
ATOM   2411 C CB  . ILE A 1 303 ? 28.276 26.764 -3.452  1.000 32.030 0  303  ILE A CB  1 ? 
ATOM   2412 C CG1 . ILE A 1 303 ? 29.767 26.855 -3.562  1.000 31.080 0  303  ILE A CG1 1 ? 
ATOM   2413 C CG2 . ILE A 1 303 ? 27.846 25.455 -2.756  1.000 28.770 0  303  ILE A CG2 1 ? 
ATOM   2414 C CD1 . ILE A 1 303 ? 30.517 26.709 -2.246  1.000 30.940 0  303  ILE A CD1 1 ? 
ATOM   2415 N N   . PHE A 1 304 ? 25.450 26.014 -5.461  1.000 22.840 0  304  PHE A N   1 ? 
ATOM   2416 C CA  . PHE A 1 304 ? 24.019 26.087 -5.671  1.000 20.590 0  304  PHE A CA  1 ? 
ATOM   2417 C C   . PHE A 1 304 ? 23.280 25.002 -4.874  1.000 19.000 0  304  PHE A C   1 ? 
ATOM   2418 O O   . PHE A 1 304 ? 22.055 24.948 -4.915  1.000 21.730 0  304  PHE A O   1 ? 
ATOM   2419 C CB  . PHE A 1 304 ? 23.682 25.974 -7.167  1.000 22.510 0  304  PHE A CB  1 ? 
ATOM   2420 C CG  . PHE A 1 304 ? 24.160 24.672 -7.815  1.000 22.470 0  304  PHE A CG  1 ? 
ATOM   2421 C CD1 . PHE A 1 304 ? 23.343 23.547 -7.815  1.000 19.410 0  304  PHE A CD1 1 ? 
ATOM   2422 C CD2 . PHE A 1 304 ? 25.404 24.579 -8.431  1.000 22.270 0  304  PHE A CD2 1 ? 
ATOM   2423 C CE1 . PHE A 1 304 ? 23.771 22.368 -8.396  1.000 20.020 0  304  PHE A CE1 1 ? 
ATOM   2424 C CE2 . PHE A 1 304 ? 25.841 23.384 -8.971  1.000 21.320 0  304  PHE A CE2 1 ? 
ATOM   2425 C CZ  . PHE A 1 304 ? 24.998 22.281 -8.964  1.000 19.330 0  304  PHE A CZ  1 ? 
ATOM   2426 N N   . VAL A 1 305 ? 24.020 24.058 -4.281  1.000 16.870 0  305  VAL A N   1 ? 
ATOM   2427 C CA  . VAL A 1 305 ? 23.401 22.996 -3.497  1.000 15.550 0  305  VAL A CA  1 ? 
ATOM   2428 C C   . VAL A 1 305 ? 24.371 22.621 -2.387  1.000 16.520 0  305  VAL A C   1 ? 
ATOM   2429 O O   . VAL A 1 305 ? 25.586 22.556 -2.597  1.000 18.090 0  305  VAL A O   1 ? 
ATOM   2430 C CB  . VAL A 1 305 ? 23.050 21.768 -4.371  1.000 15.910 0  305  VAL A CB  1 ? 
ATOM   2431 C CG1 . VAL A 1 305 ? 24.310 21.155 -4.963  1.000 15.990 0  305  VAL A CG1 1 ? 
ATOM   2432 C CG2 . VAL A 1 305 ? 22.247 20.742 -3.595  1.000 17.820 0  305  VAL A CG2 1 ? 
ATOM   2433 N N   . THR A 1 306 ? 23.833 22.334 -1.205  1.000 14.640 0  306  THR A N   1 ? 
ATOM   2434 C CA  . THR A 1 306 ? 24.623 21.913 -0.080  1.000 14.580 0  306  THR A CA  1 ? 
ATOM   2435 C C   . THR A 1 306 ? 23.877 20.851 0.706   1.000 15.350 0  306  THR A C   1 ? 
ATOM   2436 O O   . THR A 1 306 ? 22.654 20.751 0.603   1.000 15.990 0  306  THR A O   1 ? 
ATOM   2437 C CB  . THR A 1 306 ? 24.984 23.049 0.878   1.000 17.270 0  306  THR A CB  1 ? 
ATOM   2438 O OG1 . THR A 1 306 ? 23.846 23.455 1.639   1.000 18.980 0  306  THR A OG1 1 ? 
ATOM   2439 C CG2 . THR A 1 306 ? 25.599 24.245 0.179   1.000 17.860 0  306  THR A CG2 1 ? 
ATOM   2440 N N   . ALA A 1 307 ? 24.631 20.199 1.594   1.000 14.680 0  307  ALA A N   1 ? 
ATOM   2441 C CA  . ALA A 1 307 ? 24.089 19.218 2.510   1.000 16.410 0  307  ALA A CA  1 ? 
ATOM   2442 C C   . ALA A 1 307 ? 24.991 19.187 3.721   1.000 18.060 0  307  ALA A C   1 ? 
ATOM   2443 O O   . ALA A 1 307 ? 26.149 19.628 3.645   1.000 15.910 0  307  ALA A O   1 ? 
ATOM   2444 C CB  . ALA A 1 307 ? 24.037 17.821 1.869   1.000 17.740 0  307  ALA A CB  1 ? 
ATOM   2445 N N   . PRO A 1 308 ? 24.523 18.604 4.845   1.000 18.750 0  308  PRO A N   1 ? 
ATOM   2446 C CA  . PRO A 1 308 ? 25.407 18.325 5.966   1.000 17.670 0  308  PRO A CA  1 ? 
ATOM   2447 C C   . PRO A 1 308 ? 26.471 17.336 5.525   1.000 18.210 0  308  PRO A C   1 ? 
ATOM   2448 O O   . PRO A 1 308 ? 26.199 16.410 4.752   1.000 19.700 0  308  PRO A O   1 ? 
ATOM   2449 C CB  . PRO A 1 308 ? 24.505 17.746 7.076   1.000 19.120 0  308  PRO A CB  1 ? 
ATOM   2450 C CG  . PRO A 1 308 ? 23.110 17.975 6.599   1.000 19.470 0  308  PRO A CG  1 ? 
ATOM   2451 C CD  . PRO A 1 308 ? 23.145 18.151 5.093   1.000 19.500 0  308  PRO A CD  1 ? 
ATOM   2452 N N   . HIS A 1 309 ? 27.707 17.587 5.971   1.000 18.210 0  309  HIS A N   1 ? 
ATOM   2453 C CA  . HIS A 1 309 ? 28.825 16.673 5.775   1.000 20.170 0  309  HIS A CA  1 ? 
ATOM   2454 C C   . HIS A 1 309 ? 29.017 15.882 7.064   1.000 23.190 0  309  HIS A C   1 ? 
ATOM   2455 O O   . HIS A 1 309 ? 29.568 16.376 8.050   1.000 21.860 0  309  HIS A O   1 ? 
ATOM   2456 C CB  . HIS A 1 309 ? 30.077 17.431 5.322   1.000 21.550 0  309  HIS A CB  1 ? 
ATOM   2457 C CG  . HIS A 1 309 ? 31.130 16.499 4.844   1.000 25.070 0  309  HIS A CG  1 ? 
ATOM   2458 N ND1 . HIS A 1 309 ? 32.446 16.606 5.220   1.000 31.250 0  309  HIS A ND1 1 ? 
ATOM   2459 C CD2 . HIS A 1 309 ? 31.051 15.405 4.097   1.000 27.620 0  309  HIS A CD2 1 ? 
ATOM   2460 C CE1 . HIS A 1 309 ? 33.132 15.596 4.701   1.000 33.120 0  309  HIS A CE1 1 ? 
ATOM   2461 N NE2 . HIS A 1 309 ? 32.308 14.859 4.014   1.000 30.660 0  309  HIS A NE2 1 ? 
ATOM   2462 N N   . GLU A 1 310 ? 28.591 14.621 7.030   1.000 22.340 0  310  GLU A N   1 ? 
ATOM   2463 C CA  . GLU A 1 310 ? 28.356 13.867 8.246   1.000 28.770 0  310  GLU A CA  1 ? 
ATOM   2464 C C   . GLU A 1 310 ? 29.666 13.572 8.968   1.000 29.170 0  310  GLU A C   1 ? 
ATOM   2465 O O   . GLU A 1 310 ? 29.743 13.709 10.189  1.000 34.190 0  310  GLU A O   1 ? 
ATOM   2466 C CB  . GLU A 1 310 ? 27.690 12.542 7.881   1.000 34.800 0  310  GLU A CB  1 ? 
ATOM   2467 C CG  . GLU A 1 310 ? 27.115 11.804 9.084   1.000 49.560 0  310  GLU A CG  1 ? 
ATOM   2468 C CD  . GLU A 1 310 ? 26.673 10.390 8.746   1.000 59.310 0  310  GLU A CD  1 ? 
ATOM   2469 O OE1 . GLU A 1 310 ? 25.868 10.210 7.809   1.000 59.570 0  310  GLU A OE1 1 ? 
ATOM   2470 O OE2 . GLU A 1 310 ? 27.160 9.465  9.425   1.000 64.480 0  310  GLU A OE2 1 ? 
ATOM   2471 N N   . ALA A 1 311 ? 30.675 13.188 8.194   1.000 29.120 0  311  ALA A N   1 ? 
ATOM   2472 C CA  . ALA A 1 311 ? 31.967 12.795 8.728   1.000 35.670 0  311  ALA A CA  1 ? 
ATOM   2473 C C   . ALA A 1 311 ? 32.578 13.914 9.569   1.000 38.390 0  311  ALA A C   1 ? 
ATOM   2474 O O   . ALA A 1 311 ? 33.250 13.613 10.551  1.000 38.730 0  311  ALA A O   1 ? 
ATOM   2475 C CB  . ALA A 1 311 ? 32.894 12.428 7.604   1.000 35.090 0  311  ALA A CB  1 ? 
ATOM   2476 N N   . THR A 1 312 ? 32.373 15.184 9.184   1.000 29.370 0  312  THR A N   1 ? 
ATOM   2477 C CA  . THR A 1 312 ? 33.081 16.273 9.840   1.000 28.760 0  312  THR A CA  1 ? 
ATOM   2478 C C   . THR A 1 312 ? 32.106 17.202 10.559  1.000 26.490 0  312  THR A C   1 ? 
ATOM   2479 O O   . THR A 1 312 ? 32.544 18.197 11.128  1.000 26.680 0  312  THR A O   1 ? 
ATOM   2480 C CB  . THR A 1 312 ? 33.909 17.036 8.816   1.000 29.810 0  312  THR A CB  1 ? 
ATOM   2481 O OG1 . THR A 1 312 ? 32.986 17.667 7.933   1.000 29.280 0  312  THR A OG1 1 ? 
ATOM   2482 C CG2 . THR A 1 312 ? 34.841 16.150 8.009   1.000 33.640 0  312  THR A CG2 1 ? 
ATOM   2483 N N   . ALA A 1 313 ? 30.813 16.857 10.556  1.000 25.090 0  313  ALA A N   1 ? 
ATOM   2484 C CA  . ALA A 1 313 ? 29.749 17.761 10.985  1.000 24.380 0  313  ALA A CA  1 ? 
ATOM   2485 C C   . ALA A 1 313 ? 29.977 19.146 10.380  1.000 22.940 0  313  ALA A C   1 ? 
ATOM   2486 O O   . ALA A 1 313 ? 29.939 20.171 11.061  1.000 28.100 0  313  ALA A O   1 ? 
ATOM   2487 C CB  . ALA A 1 313 ? 29.687 17.804 12.508  1.000 26.580 0  313  ALA A CB  1 ? 
ATOM   2488 N N   . GLY A 1 314 ? 30.256 19.169 9.075   1.000 18.910 0  314  GLY A N   1 ? 
ATOM   2489 C CA  . GLY A 1 314 ? 30.473 20.387 8.343   1.000 19.330 0  314  GLY A CA  1 ? 
ATOM   2490 C C   . GLY A 1 314 ? 29.390 20.533 7.282   1.000 17.640 0  314  GLY A C   1 ? 
ATOM   2491 O O   . GLY A 1 314 ? 28.263 20.086 7.484   1.000 16.720 0  314  GLY A O   1 ? 
ATOM   2492 N N   . ILE A 1 315 ? 29.766 21.207 6.193   1.000 16.610 0  315  ILE A N   1 ? 
ATOM   2493 C CA  . ILE A 1 315 ? 28.916 21.482 5.049   1.000 16.980 0  315  ILE A CA  1 ? 
ATOM   2494 C C   . ILE A 1 315 ? 29.623 20.994 3.788   1.000 20.230 0  315  ILE A C   1 ? 
ATOM   2495 O O   . ILE A 1 315 ? 30.825 21.218 3.628   1.000 17.850 0  315  ILE A O   1 ? 
ATOM   2496 C CB  . ILE A 1 315 ? 28.505 22.961 4.986   1.000 17.390 0  315  ILE A CB  1 ? 
ATOM   2497 C CG1 . ILE A 1 315 ? 27.492 23.211 3.893   1.000 16.630 0  315  ILE A CG1 1 ? 
ATOM   2498 C CG2 . ILE A 1 315 ? 29.701 23.917 4.848   1.000 18.900 0  315  ILE A CG2 1 ? 
ATOM   2499 C CD1 . ILE A 1 315 ? 26.901 24.604 3.915   1.000 17.990 0  315  ILE A CD1 1 ? 
ATOM   2500 N N   . ILE A 1 316 ? 28.874 20.307 2.907   1.000 19.510 0  316  ILE A N   1 ? 
ATOM   2501 C CA  . ILE A 1 316 ? 29.382 19.900 1.604   1.000 18.020 0  316  ILE A CA  1 ? 
ATOM   2502 C C   . ILE A 1 316 ? 28.491 20.525 0.533   1.000 17.000 0  316  ILE A C   1 ? 
ATOM   2503 O O   . ILE A 1 316 ? 27.285 20.717 0.697   1.000 15.020 0  316  ILE A O   1 ? 
ATOM   2504 C CB  . ILE A 1 316 ? 29.493 18.365 1.493   1.000 19.020 0  316  ILE A CB  1 ? 
ATOM   2505 C CG1 . ILE A 1 316 ? 30.168 17.925 0.211   1.000 20.400 0  316  ILE A CG1 1 ? 
ATOM   2506 C CG2 . ILE A 1 316 ? 28.133 17.676 1.635   1.000 19.780 0  316  ILE A CG2 1 ? 
ATOM   2507 C CD1 . ILE A 1 316 ? 30.560 16.459 0.212   1.000 23.420 0  316  ILE A CD1 1 ? 
ATOM   2508 N N   . GLY A 1 317 ? 29.138 20.956 -0.552  1.000 16.770 0  317  GLY A N   1 ? 
ATOM   2509 C CA  . GLY A 1 317 ? 28.433 21.643 -1.613  1.000 18.120 0  317  GLY A CA  1 ? 
ATOM   2510 C C   . GLY A 1 317 ? 29.006 21.308 -2.992  1.000 17.090 0  317  GLY A C   1 ? 
ATOM   2511 O O   . GLY A 1 317 ? 30.089 20.770 -3.092  1.000 18.460 0  317  GLY A O   1 ? 
ATOM   2512 N N   . VAL A 1 318 ? 28.237 21.667 -4.013  1.000 16.710 0  318  VAL A N   1 ? 
ATOM   2513 C CA  . VAL A 1 318 ? 28.662 21.595 -5.397  1.000 17.770 0  318  VAL A CA  1 ? 
ATOM   2514 C C   . VAL A 1 318 ? 28.587 22.992 -6.011  1.000 19.230 0  318  VAL A C   1 ? 
ATOM   2515 O O   . VAL A 1 318 ? 27.591 23.696 -5.858  1.000 18.560 0  318  VAL A O   1 ? 
ATOM   2516 C CB  . VAL A 1 318 ? 27.811 20.591 -6.214  1.000 17.780 0  318  VAL A CB  1 ? 
ATOM   2517 C CG1 . VAL A 1 318 ? 28.426 20.339 -7.605  1.000 19.220 0  318  VAL A CG1 1 ? 
ATOM   2518 C CG2 . VAL A 1 318 ? 27.627 19.269 -5.484  1.000 20.360 0  318  VAL A CG2 1 ? 
ATOM   2519 N N   . ASN A 1 319 ? 29.633 23.389 -6.761  1.000 18.550 0  319  ASN A N   1 ? 
ATOM   2520 C CA  . ASN A 1 319 ? 29.548 24.651 -7.460  1.000 19.960 0  319  ASN A CA  1 ? 
ATOM   2521 C C   . ASN A 1 319 ? 29.369 24.408 -8.948  1.000 22.900 0  319  ASN A C   1 ? 
ATOM   2522 O O   . ASN A 1 319 ? 29.415 23.264 -9.375  1.000 22.180 0  319  ASN A O   1 ? 
ATOM   2523 C CB  . ASN A 1 319 ? 30.743 25.548 -7.152  1.000 22.890 0  319  ASN A CB  1 ? 
ATOM   2524 C CG  . ASN A 1 319 ? 32.037 25.034 -7.740  1.000 22.870 0  319  ASN A CG  1 ? 
ATOM   2525 O OD1 . ASN A 1 319 ? 32.065 24.157 -8.618  1.000 24.130 0  319  ASN A OD1 1 ? 
ATOM   2526 N ND2 . ASN A 1 319 ? 33.140 25.617 -7.298  1.000 22.950 0  319  ASN A ND2 1 ? 
ATOM   2527 N N   . ARG A 1 320 ? 29.031 25.467 -9.693  1.000 21.950 0  320  ARG A N   1 ? 
ATOM   2528 C CA  . ARG A 1 320 ? 28.698 25.330 -11.138 1.000 25.320 0  320  ARG A CA  1 ? 
ATOM   2529 C C   . ARG A 1 320 ? 29.794 24.675 -11.986 1.000 22.160 0  320  ARG A C   1 ? 
ATOM   2530 O O   . ARG A 1 320 ? 29.504 24.291 -13.137 1.000 26.010 0  320  ARG A O   1 ? 
ATOM   2531 C CB  . ARG A 1 320 ? 28.543 26.724 -11.754 1.000 30.130 0  320  ARG A CB  1 ? 
ATOM   2532 C CG  . ARG A 1 320 ? 27.409 27.520 -11.126 1.000 36.090 0  320  ARG A CG  1 ? 
ATOM   2533 C CD  . ARG A 1 320 ? 26.070 26.854 -11.389 1.000 41.980 0  320  ARG A CD  1 ? 
ATOM   2534 N NE  . ARG A 1 320 ? 25.764 26.755 -12.819 1.000 46.430 0  320  ARG A NE  1 ? 
ATOM   2535 C CZ  . ARG A 1 320 ? 25.251 27.736 -13.547 1.000 52.070 0  320  ARG A CZ  1 ? 
ATOM   2536 N NH1 . ARG A 1 320 ? 24.312 28.513 -13.041 1.000 47.040 0  320  ARG A NH1 1 ? 
ATOM   2537 N NH2 . ARG A 1 320 ? 25.682 27.935 -14.779 1.000 54.370 0  320  ARG A NH2 1 ? 
ATOM   2538 N N   . LYS A 1 321 ? 31.011 24.596 -11.455 1.000 24.680 0  321  LYS A N   1 ? 
ATOM   2539 C CA  . LYS A 1 321 ? 32.103 24.016 -12.210 1.000 27.750 0  321  LYS A CA  1 ? 
ATOM   2540 C C   . LYS A 1 321 ? 32.053 22.498 -11.986 1.000 27.560 0  321  LYS A C   1 ? 
ATOM   2541 O O   . LYS A 1 321 ? 32.687 21.735 -12.714 1.000 27.970 0  321  LYS A O   1 ? 
ATOM   2542 C CB  . LYS A 1 321 ? 33.423 24.551 -11.662 1.000 30.110 0  321  LYS A CB  1 ? 
ATOM   2543 C CG  . LYS A 1 321 ? 34.553 24.222 -12.591 1.000 37.480 0  321  LYS A CG  1 ? 
ATOM   2544 C CD  . LYS A 1 321 ? 35.934 24.385 -11.995 1.000 41.740 0  321  LYS A CD  1 ? 
ATOM   2545 C CE  . LYS A 1 321 ? 36.801 23.337 -12.586 1.000 50.420 0  321  LYS A CE  1 ? 
ATOM   2546 N NZ  . LYS A 1 321 ? 38.105 23.322 -11.932 1.000 58.880 0  321  LYS A NZ  1 ? 
ATOM   2547 N N   . GLY A 1 322 ? 31.342 22.040 -10.938 1.000 23.160 0  322  GLY A N   1 ? 
ATOM   2548 C CA  . GLY A 1 322 ? 31.286 20.618 -10.600 1.000 21.780 0  322  GLY A CA  1 ? 
ATOM   2549 C C   . GLY A 1 322 ? 32.322 20.196 -9.567  1.000 20.670 0  322  GLY A C   1 ? 
ATOM   2550 O O   . GLY A 1 322 ? 32.552 19.013 -9.324  1.000 22.110 0  322  GLY A O   1 ? 
ATOM   2551 N N   . GLN A 1 323 ? 32.952 21.169 -8.919  1.000 20.620 0  323  GLN A N   1 ? 
ATOM   2552 C CA  . GLN A 1 323 ? 33.716 20.897 -7.730  1.000 21.140 0  323  GLN A CA  1 ? 
ATOM   2553 C C   . GLN A 1 323 ? 32.797 20.570 -6.555  1.000 20.970 0  323  GLN A C   1 ? 
ATOM   2554 O O   . GLN A 1 323 ? 31.904 21.361 -6.235  1.000 21.770 0  323  GLN A O   1 ? 
ATOM   2555 C CB  . GLN A 1 323 ? 34.557 22.111 -7.355  1.000 23.200 0  323  GLN A CB  1 ? 
ATOM   2556 C CG  . GLN A 1 323 ? 35.503 21.814 -6.206  1.000 29.420 0  323  GLN A CG  1 ? 
ATOM   2557 C CD  . GLN A 1 323 ? 36.167 23.064 -5.653  1.000 37.090 0  323  GLN A CD  1 ? 
ATOM   2558 O OE1 . GLN A 1 323 ? 35.497 24.070 -5.408  1.000 33.390 0  323  GLN A OE1 1 ? 
ATOM   2559 N NE2 . GLN A 1 323 ? 37.479 23.017 -5.454  1.000 36.600 0  323  GLN A NE2 1 ? 
ATOM   2560 N N   . VAL A 1 324 ? 33.057 19.416 -5.959  1.000 21.350 0  324  VAL A N   1 ? 
ATOM   2561 C CA  . VAL A 1 324 ? 32.404 19.011 -4.734  1.000 22.440 0  324  VAL A CA  1 ? 
ATOM   2562 C C   . VAL A 1 324 ? 33.356 19.345 -3.590  1.000 23.000 0  324  VAL A C   1 ? 
ATOM   2563 O O   . VAL A 1 324 ? 34.436 18.770 -3.497  1.000 22.820 0  324  VAL A O   1 ? 
ATOM   2564 C CB  . VAL A 1 324 ? 32.027 17.529 -4.763  1.000 21.490 0  324  VAL A CB  1 ? 
ATOM   2565 C CG1 . VAL A 1 324 ? 31.308 17.144 -3.482  1.000 23.970 0  324  VAL A CG1 1 ? 
ATOM   2566 C CG2 . VAL A 1 324 ? 31.201 17.202 -6.005  1.000 23.410 0  324  VAL A CG2 1 ? 
ATOM   2567 N N   A LEU A 1 325 ? 32.911 20.236 -2.700  0.500 21.310 0  325  LEU A N   1 ? 
ATOM   2568 N N   B LEU A 1 325 ? 32.915 20.261 -2.712  0.500 21.100 0  325  LEU A N   1 ? 
ATOM   2569 C CA  A LEU A 1 325 ? 33.789 20.803 -1.699  0.500 22.350 0  325  LEU A CA  1 ? 
ATOM   2570 C CA  B LEU A 1 325 ? 33.766 20.879 -1.708  0.500 22.020 0  325  LEU A CA  1 ? 
ATOM   2571 C C   A LEU A 1 325 ? 33.086 20.789 -0.349  0.500 22.460 0  325  LEU A C   1 ? 
ATOM   2572 C C   B LEU A 1 325 ? 33.082 20.797 -0.349  0.500 22.310 0  325  LEU A C   1 ? 
ATOM   2573 O O   A LEU A 1 325 ? 31.874 21.022 -0.273  0.500 21.080 0  325  LEU A O   1 ? 
ATOM   2574 O O   B LEU A 1 325 ? 31.872 21.032 -0.260  0.500 21.050 0  325  LEU A O   1 ? 
ATOM   2575 C CB  A LEU A 1 325 ? 34.174 22.216 -2.124  0.500 24.690 0  325  LEU A CB  1 ? 
ATOM   2576 C CB  B LEU A 1 325 ? 34.015 22.343 -2.067  0.500 23.770 0  325  LEU A CB  1 ? 
ATOM   2577 C CG  A LEU A 1 325 ? 33.023 23.188 -2.377  0.500 27.980 0  325  LEU A CG  1 ? 
ATOM   2578 C CG  B LEU A 1 325 ? 34.919 23.125 -1.103  0.500 27.770 0  325  LEU A CG  1 ? 
ATOM   2579 C CD1 A LEU A 1 325 ? 32.525 23.764 -1.065  0.500 32.110 0  325  LEU A CD1 1 ? 
ATOM   2580 C CD1 B LEU A 1 325 ? 36.371 22.700 -1.212  0.500 28.870 0  325  LEU A CD1 1 ? 
ATOM   2581 C CD2 A LEU A 1 325 ? 33.425 24.303 -3.327  0.500 32.260 0  325  LEU A CD2 1 ? 
ATOM   2582 C CD2 B LEU A 1 325 ? 34.794 24.623 -1.358  0.500 29.660 0  325  LEU A CD2 1 ? 
ATOM   2583 N N   . SER A 1 326 ? 33.877 20.522 0.694   1.000 21.790 0  326  SER A N   1 ? 
ATOM   2584 C CA  . SER A 1 326 ? 33.384 20.579 2.061   1.000 22.740 0  326  SER A CA  1 ? 
ATOM   2585 C C   . SER A 1 326 ? 34.177 21.614 2.851   1.000 23.810 0  326  SER A C   1 ? 
ATOM   2586 O O   . SER A 1 326 ? 35.309 21.985 2.526   1.000 21.490 0  326  SER A O   1 ? 
ATOM   2587 C CB  . SER A 1 326 ? 33.384 19.236 2.726   1.000 24.250 0  326  SER A CB  1 ? 
ATOM   2588 O OG  . SER A 1 326 ? 34.706 18.730 2.889   1.000 27.350 0  326  SER A OG  1 ? 
ATOM   2589 N N   . VAL A 1 327 ? 33.500 22.114 3.878   1.000 19.750 0  327  VAL A N   1 ? 
ATOM   2590 C CA  . VAL A 1 327 ? 34.087 22.998 4.859   1.000 21.130 0  327  VAL A CA  1 ? 
ATOM   2591 C C   . VAL A 1 327 ? 33.654 22.450 6.216   1.000 21.110 0  327  VAL A C   1 ? 
ATOM   2592 O O   . VAL A 1 327 ? 32.463 22.152 6.419   1.000 17.920 0  327  VAL A O   1 ? 
ATOM   2593 C CB  . VAL A 1 327 ? 33.585 24.436 4.682   1.000 24.100 0  327  VAL A CB  1 ? 
ATOM   2594 C CG1 . VAL A 1 327 ? 34.252 25.387 5.672   1.000 28.670 0  327  VAL A CG1 1 ? 
ATOM   2595 C CG2 . VAL A 1 327 ? 33.726 24.962 3.251   1.000 28.340 0  327  VAL A CG2 1 ? 
ATOM   2596 N N   . CYS A 1 328 ? 34.604 22.335 7.144   1.000 19.780 0  328  CYS A N   1 ? 
ATOM   2597 C CA  . CYS A 1 328 ? 34.262 21.983 8.508   1.000 20.270 0  328  CYS A CA  1 ? 
ATOM   2598 C C   . CYS A 1 328 ? 35.127 22.803 9.482   1.000 20.820 0  328  CYS A C   1 ? 
ATOM   2599 O O   . CYS A 1 328 ? 36.034 23.526 9.053   1.000 18.960 0  328  CYS A O   1 ? 
ATOM   2600 C CB  . CYS A 1 328 ? 34.370 20.478 8.677   1.000 23.070 0  328  CYS A CB  1 ? 
ATOM   2601 S SG  . CYS A 1 328 ? 36.087 19.928 8.538   1.000 28.150 0  328  CYS A SG  1 ? 
ATOM   2602 N N   . VAL A 1 329 ? 34.773 22.734 10.775  1.000 19.740 0  329  VAL A N   1 ? 
ATOM   2603 C CA  . VAL A 1 329 ? 35.586 23.293 11.835  1.000 19.400 0  329  VAL A CA  1 ? 
ATOM   2604 C C   . VAL A 1 329 ? 36.908 22.539 11.847  1.000 20.490 0  329  VAL A C   1 ? 
ATOM   2605 O O   . VAL A 1 329 ? 36.927 21.313 11.816  1.000 19.680 0  329  VAL A O   1 ? 
ATOM   2606 C CB  . VAL A 1 329 ? 34.853 23.187 13.187  1.000 21.540 0  329  VAL A CB  1 ? 
ATOM   2607 C CG1 . VAL A 1 329 ? 35.785 23.462 14.368  1.000 22.070 0  329  VAL A CG1 1 ? 
ATOM   2608 C CG2 . VAL A 1 329 ? 33.658 24.137 13.204  1.000 23.470 0  329  VAL A CG2 1 ? 
ATOM   2609 N N   . GLU A 1 330 ? 37.997 23.303 11.927  1.000 21.610 0  330  GLU A N   1 ? 
ATOM   2610 C CA  . GLU A 1 330 ? 39.315 22.728 12.159  1.000 24.220 0  330  GLU A CA  1 ? 
ATOM   2611 C C   . GLU A 1 330 ? 39.511 22.632 13.667  1.000 22.190 0  330  GLU A C   1 ? 
ATOM   2612 O O   . GLU A 1 330 ? 39.713 23.655 14.307  1.000 22.650 0  330  GLU A O   1 ? 
ATOM   2613 C CB  . GLU A 1 330 ? 40.360 23.618 11.481  1.000 27.390 0  330  GLU A CB  1 ? 
ATOM   2614 C CG  . GLU A 1 330 ? 41.783 23.149 11.784  1.000 36.120 0  330  GLU A CG  1 ? 
ATOM   2615 C CD  . GLU A 1 330 ? 41.983 21.655 11.659  1.000 40.300 0  330  GLU A CD  1 ? 
ATOM   2616 O OE1 . GLU A 1 330 ? 41.973 21.207 10.487  1.000 41.420 0  330  GLU A OE1 1 ? 
ATOM   2617 O OE2 . GLU A 1 330 ? 42.104 20.955 12.711  1.000 49.630 0  330  GLU A OE2 1 ? 
ATOM   2618 N N   . GLU A 1 331 ? 39.335 21.427 14.213  1.000 21.130 0  331  GLU A N   1 ? 
ATOM   2619 C CA  . GLU A 1 331 ? 39.198 21.208 15.641  1.000 24.930 0  331  GLU A CA  1 ? 
ATOM   2620 C C   . GLU A 1 331 ? 40.450 21.620 16.408  1.000 27.230 0  331  GLU A C   1 ? 
ATOM   2621 O O   . GLU A 1 331 ? 40.343 21.952 17.573  1.000 27.530 0  331  GLU A O   1 ? 
ATOM   2622 C CB  . GLU A 1 331 ? 38.838 19.772 15.992  1.000 25.460 0  331  GLU A CB  1 ? 
ATOM   2623 C CG  . GLU A 1 331 ? 37.400 19.478 15.570  1.000 31.840 0  331  GLU A CG  1 ? 
ATOM   2624 C CD  . GLU A 1 331 ? 36.810 18.192 16.096  1.000 37.070 0  331  GLU A CD  1 ? 
ATOM   2625 O OE1 . GLU A 1 331 ? 37.619 17.394 16.599  1.000 41.420 0  331  GLU A OE1 1 ? 
ATOM   2626 O OE2 . GLU A 1 331 ? 35.565 18.005 16.062  1.000 39.510 0  331  GLU A OE2 1 ? 
ATOM   2627 N N   . GLU A 1 332 ? 41.614 21.594 15.768  1.000 28.290 0  332  GLU A N   1 ? 
ATOM   2628 C CA  . GLU A 1 332 ? 42.831 21.904 16.502  1.000 33.290 0  332  GLU A CA  1 ? 
ATOM   2629 C C   . GLU A 1 332 ? 43.130 23.400 16.469  1.000 30.370 0  332  GLU A C   1 ? 
ATOM   2630 O O   . GLU A 1 332 ? 43.948 23.879 17.246  1.000 29.100 0  332  GLU A O   1 ? 
ATOM   2631 C CB  . GLU A 1 332 ? 43.889 20.959 15.938  1.000 38.500 0  332  GLU A CB  1 ? 
ATOM   2632 C CG  . GLU A 1 332 ? 43.521 19.504 16.223  1.000 49.640 0  332  GLU A CG  1 ? 
ATOM   2633 C CD  . GLU A 1 332 ? 44.564 18.481 15.802  1.000 63.720 0  332  GLU A CD  1 ? 
ATOM   2634 O OE1 . GLU A 1 332 ? 44.203 17.285 15.734  1.000 70.880 0  332  GLU A OE1 1 ? 
ATOM   2635 O OE2 . GLU A 1 332 ? 45.736 18.865 15.563  1.000 73.120 0  332  GLU A OE2 1 ? 
ATOM   2636 N N   . ASN A 1 333 ? 42.489 24.140 15.559  1.000 24.390 0  333  ASN A N   1 ? 
ATOM   2637 C CA  . ASN A 1 333 ? 42.821 25.534 15.345  1.000 23.310 0  333  ASN A CA  1 ? 
ATOM   2638 C C   . ASN A 1 333 ? 41.750 26.466 15.880  1.000 21.270 0  333  ASN A C   1 ? 
ATOM   2639 O O   . ASN A 1 333 ? 42.029 27.638 16.054  1.000 22.390 0  333  ASN A O   1 ? 
ATOM   2640 C CB  . ASN A 1 333 ? 42.998 25.901 13.873  1.000 28.610 0  333  ASN A CB  1 ? 
ATOM   2641 C CG  . ASN A 1 333 ? 44.195 25.231 13.246  1.000 33.550 0  333  ASN A CG  1 ? 
ATOM   2642 O OD1 . ASN A 1 333 ? 44.959 24.585 13.947  1.000 32.690 0  333  ASN A OD1 1 ? 
ATOM   2643 N ND2 . ASN A 1 333 ? 44.378 25.374 11.942  1.000 36.820 0  333  ASN A ND2 1 ? 
ATOM   2644 N N   . ILE A 1 334 ? 40.488 26.017 16.003  1.000 20.370 0  334  ILE A N   1 ? 
ATOM   2645 C CA  . ILE A 1 334 ? 39.450 27.028 16.120  1.000 19.210 0  334  ILE A CA  1 ? 
ATOM   2646 C C   . ILE A 1 334 ? 39.604 27.823 17.421  1.000 18.350 0  334  ILE A C   1 ? 
ATOM   2647 O O   . ILE A 1 334 ? 39.388 29.034 17.416  1.000 18.120 0  334  ILE A O   1 ? 
ATOM   2648 C CB  . ILE A 1 334 ? 38.032 26.434 15.982  1.000 18.530 0  334  ILE A CB  1 ? 
ATOM   2649 C CG1 . ILE A 1 334 ? 36.983 27.515 16.130  1.000 20.830 0  334  ILE A CG1 1 ? 
ATOM   2650 C CG2 . ILE A 1 334 ? 37.823 25.291 16.951  1.000 22.220 0  334  ILE A CG2 1 ? 
ATOM   2651 C CD1 . ILE A 1 334 ? 35.654 27.213 15.455  1.000 20.200 0  334  ILE A CD1 1 ? 
ATOM   2652 N N   . ILE A 1 335 ? 39.984 27.153 18.515  1.000 18.870 0  335  ILE A N   1 ? 
ATOM   2653 C CA  . ILE A 1 335 ? 40.021 27.822 19.804  1.000 18.020 0  335  ILE A CA  1 ? 
ATOM   2654 C C   . ILE A 1 335 ? 41.168 28.846 19.833  1.000 21.100 0  335  ILE A C   1 ? 
ATOM   2655 O O   . ILE A 1 335 ? 40.943 30.006 20.165  1.000 20.360 0  335  ILE A O   1 ? 
ATOM   2656 C CB  . ILE A 1 335 ? 40.058 26.811 20.955  1.000 20.110 0  335  ILE A CB  1 ? 
ATOM   2657 C CG1 . ILE A 1 335 ? 38.788 25.926 20.986  1.000 18.780 0  335  ILE A CG1 1 ? 
ATOM   2658 C CG2 . ILE A 1 335 ? 40.261 27.549 22.289  1.000 20.770 0  335  ILE A CG2 1 ? 
ATOM   2659 C CD1 . ILE A 1 335 ? 37.491 26.692 20.990  1.000 21.560 0  335  ILE A CD1 1 ? 
ATOM   2660 N N   . PRO A 1 336 ? 42.409 28.504 19.451  1.000 22.010 0  336  PRO A N   1 ? 
ATOM   2661 C CA  . PRO A 1 336 ? 43.452 29.521 19.350  1.000 26.500 0  336  PRO A CA  1 ? 
ATOM   2662 C C   . PRO A 1 336 ? 43.182 30.629 18.347  1.000 24.250 0  336  PRO A C   1 ? 
ATOM   2663 O O   . PRO A 1 336 ? 43.543 31.784 18.600  1.000 24.830 0  336  PRO A O   1 ? 
ATOM   2664 C CB  . PRO A 1 336 ? 44.724 28.758 19.048  1.000 26.680 0  336  PRO A CB  1 ? 
ATOM   2665 C CG  . PRO A 1 336 ? 44.292 27.389 18.651  1.000 27.140 0  336  PRO A CG  1 ? 
ATOM   2666 C CD  . PRO A 1 336 ? 42.900 27.159 19.167  1.000 22.620 0  336  PRO A CD  1 ? 
ATOM   2667 N N   . TYR A 1 337 ? 42.477 30.296 17.248  1.000 23.170 0  337  TYR A N   1 ? 
ATOM   2668 C CA  . TYR A 1 337 ? 42.058 31.328 16.321  1.000 22.340 0  337  TYR A CA  1 ? 
ATOM   2669 C C   . TYR A 1 337 ? 41.193 32.357 17.032  1.000 21.480 0  337  TYR A C   1 ? 
ATOM   2670 O O   . TYR A 1 337 ? 41.362 33.568 16.862  1.000 21.300 0  337  TYR A O   1 ? 
ATOM   2671 C CB  . TYR A 1 337 ? 41.306 30.674 15.152  1.000 24.360 0  337  TYR A CB  1 ? 
ATOM   2672 C CG  . TYR A 1 337 ? 40.882 31.720 14.138  1.000 23.620 0  337  TYR A CG  1 ? 
ATOM   2673 C CD1 . TYR A 1 337 ? 41.797 32.153 13.191  1.000 25.910 0  337  TYR A CD1 1 ? 
ATOM   2674 C CD2 . TYR A 1 337 ? 39.613 32.310 14.133  1.000 24.750 0  337  TYR A CD2 1 ? 
ATOM   2675 C CE1 . TYR A 1 337 ? 41.486 33.138 12.279  1.000 26.720 0  337  TYR A CE1 1 ? 
ATOM   2676 C CE2 . TYR A 1 337 ? 39.291 33.296 13.206  1.000 22.340 0  337  TYR A CE2 1 ? 
ATOM   2677 C CZ  . TYR A 1 337 ? 40.229 33.694 12.273  1.000 27.090 0  337  TYR A CZ  1 ? 
ATOM   2678 O OH  . TYR A 1 337 ? 40.031 34.624 11.304  1.000 31.720 0  337  TYR A OH  1 ? 
ATOM   2679 N N   . ILE A 1 338 ? 40.190 31.869 17.787  1.000 21.040 0  338  ILE A N   1 ? 
ATOM   2680 C CA  . ILE A 1 338 ? 39.267 32.788 18.400  1.000 19.470 0  338  ILE A CA  1 ? 
ATOM   2681 C C   . ILE A 1 338 ? 40.013 33.642 19.437  1.000 20.680 0  338  ILE A C   1 ? 
ATOM   2682 O O   . ILE A 1 338 ? 39.755 34.840 19.586  1.000 22.160 0  338  ILE A O   1 ? 
ATOM   2683 C CB  . ILE A 1 338 ? 38.070 32.005 18.984  1.000 19.230 0  338  ILE A CB  1 ? 
ATOM   2684 C CG1 . ILE A 1 338 ? 37.208 31.490 17.855  1.000 21.200 0  338  ILE A CG1 1 ? 
ATOM   2685 C CG2 . ILE A 1 338 ? 37.265 32.909 19.904  1.000 21.110 0  338  ILE A CG2 1 ? 
ATOM   2686 C CD1 . ILE A 1 338 ? 36.132 30.509 18.293  1.000 21.500 0  338  ILE A CD1 1 ? 
ATOM   2687 N N   . THR A 1 339 ? 40.935 33.014 20.159  1.000 25.090 0  339  THR A N   1 ? 
ATOM   2688 C CA  . THR A 1 339 ? 41.655 33.723 21.212  1.000 23.730 0  339  THR A CA  1 ? 
ATOM   2689 C C   . THR A 1 339 ? 42.612 34.755 20.605  1.000 25.910 0  339  THR A C   1 ? 
ATOM   2690 O O   . THR A 1 339 ? 42.572 35.927 20.972  1.000 27.830 0  339  THR A O   1 ? 
ATOM   2691 C CB  . THR A 1 339 ? 42.424 32.718 22.053  1.000 26.730 0  339  THR A CB  1 ? 
ATOM   2692 O OG1 . THR A 1 339 ? 41.541 31.766 22.648  1.000 24.800 0  339  THR A OG1 1 ? 
ATOM   2693 C CG2 . THR A 1 339 ? 43.203 33.420 23.154  1.000 27.780 0  339  THR A CG2 1 ? 
ATOM   2694 N N   . ASN A 1 340 ? 43.402 34.308 19.633  1.000 28.110 0  340  ASN A N   1 ? 
ATOM   2695 C CA  . ASN A 1 340 ? 44.538 35.080 19.144  1.000 30.220 0  340  ASN A CA  1 ? 
ATOM   2696 C C   . ASN A 1 340 ? 44.155 36.013 17.991  1.000 33.970 0  340  ASN A C   1 ? 
ATOM   2697 O O   . ASN A 1 340 ? 44.583 37.168 17.988  1.000 37.930 0  340  ASN A O   1 ? 
ATOM   2698 C CB  . ASN A 1 340 ? 45.704 34.137 18.899  1.000 30.460 0  340  ASN A CB  1 ? 
ATOM   2699 C CG  . ASN A 1 340 ? 46.121 33.493 20.196  1.000 32.760 0  340  ASN A CG  1 ? 
ATOM   2700 O OD1 . ASN A 1 340 ? 46.368 34.188 21.185  1.000 38.370 0  340  ASN A OD1 1 ? 
ATOM   2701 N ND2 . ASN A 1 340 ? 46.170 32.177 20.244  1.000 37.170 0  340  ASN A ND2 1 ? 
ATOM   2702 N N   . VAL A 1 341 ? 43.339 35.553 17.025  1.000 23.980 0  341  VAL A N   1 ? 
ATOM   2703 C CA  . VAL A 1 341 ? 43.037 36.372 15.868  1.000 25.790 0  341  VAL A CA  1 ? 
ATOM   2704 C C   . VAL A 1 341 ? 41.822 37.252 16.122  1.000 27.220 0  341  VAL A C   1 ? 
ATOM   2705 O O   . VAL A 1 341 ? 41.841 38.418 15.769  1.000 28.180 0  341  VAL A O   1 ? 
ATOM   2706 C CB  . VAL A 1 341 ? 42.900 35.484 14.622  1.000 26.990 0  341  VAL A CB  1 ? 
ATOM   2707 C CG1 . VAL A 1 341 ? 42.482 36.281 13.392  1.000 28.990 0  341  VAL A CG1 1 ? 
ATOM   2708 C CG2 . VAL A 1 341 ? 44.168 34.683 14.355  1.000 28.410 0  341  VAL A CG2 1 ? 
ATOM   2709 N N   . LEU A 1 342 ? 40.737 36.699 16.719  1.000 26.840 0  342  LEU A N   1 ? 
ATOM   2710 C CA  . LEU A 1 342 ? 39.556 37.480 17.046  1.000 26.280 0  342  LEU A CA  1 ? 
ATOM   2711 C C   . LEU A 1 342 ? 39.743 38.215 18.363  1.000 27.210 0  342  LEU A C   1 ? 
ATOM   2712 O O   . LEU A 1 342 ? 38.934 39.051 18.718  1.000 28.750 0  342  LEU A O   1 ? 
ATOM   2713 C CB  . LEU A 1 342 ? 38.357 36.541 17.183  1.000 32.600 0  342  LEU A CB  1 ? 
ATOM   2714 C CG  . LEU A 1 342 ? 37.874 35.854 15.911  1.000 32.760 0  342  LEU A CG  1 ? 
ATOM   2715 C CD1 . LEU A 1 342 ? 36.533 35.183 16.233  1.000 34.520 0  342  LEU A CD1 1 ? 
ATOM   2716 C CD2 . LEU A 1 342 ? 37.738 36.831 14.743  1.000 31.640 0  342  LEU A CD2 1 ? 
ATOM   2717 N N   . GLN A 1 343 ? 40.723 37.800 19.163  1.000 27.060 0  343  GLN A N   1 ? 
ATOM   2718 C CA  . GLN A 1 343 ? 40.939 38.438 20.450  1.000 30.690 0  343  GLN A CA  1 ? 
ATOM   2719 C C   . GLN A 1 343 ? 39.659 38.334 21.266  1.000 25.670 0  343  GLN A C   1 ? 
ATOM   2720 O O   . GLN A 1 343 ? 39.230 39.287 21.938  1.000 26.380 0  343  GLN A O   1 ? 
ATOM   2721 C CB  . GLN A 1 343 ? 41.412 39.880 20.276  1.000 36.590 0  343  GLN A CB  1 ? 
ATOM   2722 C CG  . GLN A 1 343 ? 42.680 39.987 19.436  1.000 43.190 0  343  GLN A CG  1 ? 
ATOM   2723 C CD  . GLN A 1 343 ? 43.334 41.343 19.563  1.000 52.970 0  343  GLN A CD  1 ? 
ATOM   2724 O OE1 . GLN A 1 343 ? 42.728 42.377 19.256  1.000 59.230 0  343  GLN A OE1 1 ? 
ATOM   2725 N NE2 . GLN A 1 343 ? 44.562 41.355 20.056  1.000 59.000 0  343  GLN A NE2 1 ? 
ATOM   2726 N N   . ASN A 1 344 ? 39.082 37.124 21.244  1.000 22.700 0  344  ASN A N   1 ? 
ATOM   2727 C CA  . ASN A 1 344 ? 37.862 36.879 21.983  1.000 22.030 0  344  ASN A CA  1 ? 
ATOM   2728 C C   . ASN A 1 344 ? 38.096 35.697 22.917  1.000 21.060 0  344  ASN A C   1 ? 
ATOM   2729 O O   . ASN A 1 344 ? 37.518 34.621 22.736  1.000 20.410 0  344  ASN A O   1 ? 
ATOM   2730 C CB  . ASN A 1 344 ? 36.688 36.686 21.027  1.000 23.330 0  344  ASN A CB  1 ? 
ATOM   2731 C CG  . ASN A 1 344 ? 35.352 36.799 21.716  1.000 22.280 0  344  ASN A CG  1 ? 
ATOM   2732 O OD1 . ASN A 1 344 ? 35.264 36.615 22.926  1.000 20.730 0  344  ASN A OD1 1 ? 
ATOM   2733 N ND2 . ASN A 1 344 ? 34.306 37.099 20.965  1.000 21.860 0  344  ASN A ND2 1 ? 
ATOM   2734 N N   . PRO A 1 345 ? 38.899 35.829 24.004  1.000 19.960 0  345  PRO A N   1 ? 
ATOM   2735 C CA  . PRO A 1 345 ? 39.078 34.712 24.928  1.000 20.480 0  345  PRO A CA  1 ? 
ATOM   2736 C C   . PRO A 1 345 ? 37.792 34.219 25.560  1.000 19.640 0  345  PRO A C   1 ? 
ATOM   2737 O O   . PRO A 1 345 ? 37.702 33.044 25.889  1.000 20.400 0  345  PRO A O   1 ? 
ATOM   2738 C CB  . PRO A 1 345 ? 40.085 35.199 25.983  1.000 23.760 0  345  PRO A CB  1 ? 
ATOM   2739 C CG  . PRO A 1 345 ? 40.102 36.690 25.796  1.000 22.940 0  345  PRO A CG  1 ? 
ATOM   2740 C CD  . PRO A 1 345 ? 39.736 36.987 24.356  1.000 23.970 0  345  PRO A CD  1 ? 
ATOM   2741 N N   A ASP A 1 346 ? 36.797 35.097 25.749  0.300 19.360 0  346  ASP A N   1 ? 
ATOM   2742 N N   B ASP A 1 346 ? 36.824 35.124 25.756  0.700 20.570 0  346  ASP A N   1 ? 
ATOM   2743 C CA  A ASP A 1 346 ? 35.553 34.670 26.372  0.300 20.080 0  346  ASP A CA  1 ? 
ATOM   2744 C CA  B ASP A 1 346 ? 35.549 34.739 26.336  0.700 24.510 0  346  ASP A CA  1 ? 
ATOM   2745 C C   A ASP A 1 346 ? 34.823 33.658 25.487  0.300 19.770 0  346  ASP A C   1 ? 
ATOM   2746 C C   B ASP A 1 346 ? 34.889 33.653 25.478  0.700 22.090 0  346  ASP A C   1 ? 
ATOM   2747 O O   A ASP A 1 346 ? 34.337 32.641 25.982  0.300 19.070 0  346  ASP A O   1 ? 
ATOM   2748 O O   B ASP A 1 346 ? 34.555 32.571 25.968  0.700 20.960 0  346  ASP A O   1 ? 
ATOM   2749 C CB  A ASP A 1 346 ? 34.636 35.838 26.689  0.300 21.170 0  346  ASP A CB  1 ? 
ATOM   2750 C CB  B ASP A 1 346 ? 34.652 35.959 26.462  0.700 31.040 0  346  ASP A CB  1 ? 
ATOM   2751 C CG  A ASP A 1 346 ? 35.188 36.860 27.672  0.300 21.750 0  346  ASP A CG  1 ? 
ATOM   2752 C CG  B ASP A 1 346 ? 33.443 35.817 27.375  0.700 37.430 0  346  ASP A CG  1 ? 
ATOM   2753 O OD1 A ASP A 1 346 ? 35.610 36.451 28.765  0.300 20.100 0  346  ASP A OD1 1 ? 
ATOM   2754 O OD1 B ASP A 1 346 ? 32.564 34.983 27.069  0.700 41.050 0  346  ASP A OD1 1 ? 
ATOM   2755 O OD2 A ASP A 1 346 ? 35.168 38.063 27.329  0.300 24.480 0  346  ASP A OD2 1 ? 
ATOM   2756 O OD2 B ASP A 1 346 ? 33.379 36.584 28.369  0.700 46.150 0  346  ASP A OD2 1 ? 
ATOM   2757 N N   . LEU A 1 347 ? 34.722 33.952 24.184  1.000 19.870 0  347  LEU A N   1 ? 
ATOM   2758 C CA  . LEU A 1 347 ? 34.121 33.011 23.254  1.000 19.330 0  347  LEU A CA  1 ? 
ATOM   2759 C C   . LEU A 1 347 ? 34.973 31.749 23.157  1.000 18.610 0  347  LEU A C   1 ? 
ATOM   2760 O O   . LEU A 1 347 ? 34.467 30.652 23.117  1.000 19.430 0  347  LEU A O   1 ? 
ATOM   2761 C CB  . LEU A 1 347 ? 33.854 33.608 21.876  1.000 19.790 0  347  LEU A CB  1 ? 
ATOM   2762 C CG  . LEU A 1 347 ? 33.232 32.654 20.841  1.000 20.290 0  347  LEU A CG  1 ? 
ATOM   2763 C CD1 . LEU A 1 347 ? 31.831 32.272 21.232  1.000 22.820 0  347  LEU A CD1 1 ? 
ATOM   2764 C CD2 . LEU A 1 347 ? 33.254 33.344 19.485  1.000 22.980 0  347  LEU A CD2 1 ? 
ATOM   2765 N N   . ALA A 1 348 ? 36.287 31.886 23.084  1.000 17.570 0  348  ALA A N   1 ? 
ATOM   2766 C CA  . ALA A 1 348 ? 37.196 30.752 22.985  1.000 17.400 0  348  ALA A CA  1 ? 
ATOM   2767 C C   . ALA A 1 348 ? 37.033 29.776 24.144  1.000 18.230 0  348  ALA A C   1 ? 
ATOM   2768 O O   . ALA A 1 348 ? 36.929 28.562 23.957  1.000 19.890 0  348  ALA A O   1 ? 
ATOM   2769 C CB  . ALA A 1 348 ? 38.649 31.223 22.871  1.000 17.950 0  348  ALA A CB  1 ? 
ATOM   2770 N N   . LEU A 1 349 ? 36.987 30.306 25.370  1.000 17.130 0  349  LEU A N   1 ? 
ATOM   2771 C CA  . LEU A 1 349 ? 36.842 29.472 26.542  1.000 18.170 0  349  LEU A CA  1 ? 
ATOM   2772 C C   . LEU A 1 349 ? 35.491 28.761 26.573  1.000 17.310 0  349  LEU A C   1 ? 
ATOM   2773 O O   . LEU A 1 349 ? 35.408 27.560 26.848  1.000 20.670 0  349  LEU A O   1 ? 
ATOM   2774 C CB  . LEU A 1 349 ? 37.018 30.359 27.768  1.000 19.420 0  349  LEU A CB  1 ? 
ATOM   2775 C CG  . LEU A 1 349 ? 36.983 29.616 29.094  1.000 20.730 0  349  LEU A CG  1 ? 
ATOM   2776 C CD1 . LEU A 1 349 ? 38.055 28.553 29.111  1.000 21.760 0  349  LEU A CD1 1 ? 
ATOM   2777 C CD2 . LEU A 1 349 ? 37.168 30.653 30.213  1.000 22.000 0  349  LEU A CD2 1 ? 
ATOM   2778 N N   . ARG A 1 350 ? 34.444 29.480 26.220  1.000 18.630 0  350  ARG A N   1 ? 
ATOM   2779 C CA  . ARG A 1 350 ? 33.116 28.875 26.188  1.000 18.650 0  350  ARG A CA  1 ? 
ATOM   2780 C C   . ARG A 1 350 ? 33.064 27.722 25.193  1.000 18.150 0  350  ARG A C   1 ? 
ATOM   2781 O O   . ARG A 1 350 ? 32.604 26.622 25.527  1.000 19.440 0  350  ARG A O   1 ? 
ATOM   2782 C CB  . ARG A 1 350 ? 32.095 29.986 25.941  1.000 19.640 0  350  ARG A CB  1 ? 
ATOM   2783 C CG  . ARG A 1 350 ? 30.711 29.461 25.633  1.000 21.950 0  350  ARG A CG  1 ? 
ATOM   2784 C CD  . ARG A 1 350 ? 30.133 28.572 26.707  1.000 27.200 0  350  ARG A CD  1 ? 
ATOM   2785 N NE  . ARG A 1 350 ? 28.725 28.244 26.437  1.000 27.750 0  350  ARG A NE  1 ? 
ATOM   2786 C CZ  . ARG A 1 350 ? 28.079 27.150 26.814  1.000 28.760 0  350  ARG A CZ  1 ? 
ATOM   2787 N NH1 . ARG A 1 350 ? 28.648 26.280 27.606  1.000 30.870 0  350  ARG A NH1 1 ? 
ATOM   2788 N NH2 . ARG A 1 350 ? 26.844 26.936 26.409  1.000 33.290 0  350  ARG A NH2 1 ? 
ATOM   2789 N N   . MET A 1 351 ? 33.542 27.946 23.969  1.000 20.610 0  351  MET A N   1 ? 
ATOM   2790 C CA  . MET A 1 351 ? 33.479 26.919 22.938  1.000 23.650 0  351  MET A CA  1 ? 
ATOM   2791 C C   . MET A 1 351 ? 34.358 25.727 23.298  1.000 22.920 0  351  MET A C   1 ? 
ATOM   2792 O O   . MET A 1 351 ? 33.980 24.579 23.064  1.000 22.980 0  351  MET A O   1 ? 
ATOM   2793 C CB  . MET A 1 351 ? 33.822 27.482 21.552  1.000 24.910 0  351  MET A CB  1 ? 
ATOM   2794 C CG  . MET A 1 351 ? 32.788 28.480 21.073  1.000 28.730 0  351  MET A CG  1 ? 
ATOM   2795 S SD  . MET A 1 351 ? 32.961 29.111 19.381  1.000 31.510 0  351  MET A SD  1 ? 
ATOM   2796 C CE  . MET A 1 351 ? 33.334 27.535 18.591  1.000 29.040 0  351  MET A CE  1 ? 
ATOM   2797 N N   . ALA A 1 352 ? 35.508 25.990 23.935  1.000 19.400 0  352  ALA A N   1 ? 
ATOM   2798 C CA  . ALA A 1 352 ? 36.403 24.918 24.311  1.000 20.440 0  352  ALA A CA  1 ? 
ATOM   2799 C C   . ALA A 1 352 ? 35.704 23.918 25.229  1.000 20.540 0  352  ALA A C   1 ? 
ATOM   2800 O O   . ALA A 1 352 ? 35.751 22.708 24.978  1.000 22.820 0  352  ALA A O   1 ? 
ATOM   2801 C CB  . ALA A 1 352 ? 37.668 25.451 24.933  1.000 19.970 0  352  ALA A CB  1 ? 
ATOM   2802 N N   . VAL A 1 353 ? 35.023 24.429 26.253  1.000 20.580 0  353  VAL A N   1 ? 
ATOM   2803 C CA  . VAL A 1 353 ? 34.373 23.575 27.222  1.000 21.200 0  353  VAL A CA  1 ? 
ATOM   2804 C C   . VAL A 1 353 ? 33.065 23.043 26.654  1.000 23.970 0  353  VAL A C   1 ? 
ATOM   2805 O O   . VAL A 1 353 ? 32.740 21.899 26.904  1.000 25.320 0  353  VAL A O   1 ? 
ATOM   2806 C CB  . VAL A 1 353 ? 34.095 24.257 28.565  1.000 24.420 0  353  VAL A CB  1 ? 
ATOM   2807 C CG1 . VAL A 1 353 ? 33.194 23.376 29.431  1.000 29.170 0  353  VAL A CG1 1 ? 
ATOM   2808 C CG2 . VAL A 1 353 ? 35.398 24.600 29.268  1.000 25.210 0  353  VAL A CG2 1 ? 
ATOM   2809 N N   . ARG A 1 354 ? 32.334 23.879 25.916  1.000 23.470 0  354  ARG A N   1 ? 
ATOM   2810 C CA  . ARG A 1 354 ? 31.005 23.519 25.431  1.000 23.560 0  354  ARG A CA  1 ? 
ATOM   2811 C C   . ARG A 1 354 ? 31.128 22.336 24.475  1.000 26.890 0  354  ARG A C   1 ? 
ATOM   2812 O O   . ARG A 1 354 ? 30.330 21.411 24.521  1.000 26.550 0  354  ARG A O   1 ? 
ATOM   2813 C CB  . ARG A 1 354 ? 30.337 24.722 24.753  1.000 22.610 0  354  ARG A CB  1 ? 
ATOM   2814 C CG  . ARG A 1 354 ? 28.975 24.470 24.112  1.000 22.670 0  354  ARG A CG  1 ? 
ATOM   2815 C CD  . ARG A 1 354 ? 28.492 25.744 23.493  1.000 21.240 0  354  ARG A CD  1 ? 
ATOM   2816 N NE  . ARG A 1 354 ? 29.192 25.876 22.205  1.000 22.330 0  354  ARG A NE  1 ? 
ATOM   2817 C CZ  . ARG A 1 354 ? 29.093 26.886 21.360  1.000 22.920 0  354  ARG A CZ  1 ? 
ATOM   2818 N NH1 . ARG A 1 354 ? 28.430 27.962 21.709  1.000 21.850 0  354  ARG A NH1 1 ? 
ATOM   2819 N NH2 . ARG A 1 354 ? 29.664 26.790 20.157  1.000 20.900 0  354  ARG A NH2 1 ? 
ATOM   2820 N N   . ASN A 1 355 ? 32.144 22.364 23.619  1.000 23.090 0  355  ASN A N   1 ? 
ATOM   2821 C CA  . ASN A 1 355 ? 32.242 21.423 22.519  1.000 25.030 0  355  ASN A CA  1 ? 
ATOM   2822 C C   . ASN A 1 355 ? 33.482 20.542 22.680  1.000 25.580 0  355  ASN A C   1 ? 
ATOM   2823 O O   . ASN A 1 355 ? 33.782 19.781 21.761  1.000 23.710 0  355  ASN A O   1 ? 
ATOM   2824 C CB  . ASN A 1 355 ? 32.137 22.125 21.166  1.000 23.700 0  355  ASN A CB  1 ? 
ATOM   2825 C CG  . ASN A 1 355 ? 30.882 22.951 21.088  1.000 24.680 0  355  ASN A CG  1 ? 
ATOM   2826 O OD1 . ASN A 1 355 ? 30.943 24.177 21.145  1.000 26.350 0  355  ASN A OD1 1 ? 
ATOM   2827 N ND2 . ASN A 1 355 ? 29.726 22.302 21.031  1.000 25.720 0  355  ASN A ND2 1 ? 
ATOM   2828 N N   . ASN A 1 356 ? 34.124 20.580 23.862  1.000 26.570 0  356  ASN A N   1 ? 
ATOM   2829 C CA  . ASN A 1 356 ? 35.176 19.633 24.207  1.000 30.840 0  356  ASN A CA  1 ? 
ATOM   2830 C C   . ASN A 1 356 ? 36.324 19.746 23.206  1.000 32.850 0  356  ASN A C   1 ? 
ATOM   2831 O O   . ASN A 1 356 ? 36.744 18.756 22.605  1.000 31.790 0  356  ASN A O   1 ? 
ATOM   2832 C CB  . ASN A 1 356 ? 34.615 18.215 24.293  1.000 37.750 0  356  ASN A CB  1 ? 
ATOM   2833 C CG  . ASN A 1 356 ? 35.563 17.216 24.920  1.000 48.940 0  356  ASN A CG  1 ? 
ATOM   2834 O OD1 . ASN A 1 356 ? 36.361 17.595 25.785  1.000 64.550 0  356  ASN A OD1 1 ? 
ATOM   2835 N ND2 . ASN A 1 356 ? 35.542 15.963 24.493  1.000 49.660 0  356  ASN A ND2 1 ? 
ATOM   2836 N N   . LEU A 1 357 ? 36.818 20.972 23.016  1.000 26.960 0  357  LEU A N   1 ? 
ATOM   2837 C CA  . LEU A 1 357 ? 37.881 21.248 22.070  1.000 28.210 0  357  LEU A CA  1 ? 
ATOM   2838 C C   . LEU A 1 357 ? 39.107 21.697 22.846  1.000 29.750 0  357  LEU A C   1 ? 
ATOM   2839 O O   . LEU A 1 357 ? 38.988 22.286 23.906  1.000 28.230 0  357  LEU A O   1 ? 
ATOM   2840 C CB  . LEU A 1 357 ? 37.485 22.330 21.074  1.000 28.650 0  357  LEU A CB  1 ? 
ATOM   2841 C CG  . LEU A 1 357 ? 36.248 22.015 20.231  1.000 32.020 0  357  LEU A CG  1 ? 
ATOM   2842 C CD1 . LEU A 1 357 ? 35.705 23.228 19.510  1.000 34.180 0  357  LEU A CD1 1 ? 
ATOM   2843 C CD2 . LEU A 1 357 ? 36.582 20.909 19.250  1.000 33.270 0  357  LEU A CD2 1 ? 
ATOM   2844 N N   . ALA A 1 358 ? 40.279 21.452 22.268  1.000 31.420 0  358  ALA A N   1 ? 
ATOM   2845 C CA  . ALA A 1 358 ? 41.524 21.815 22.922  1.000 29.440 0  358  ALA A CA  1 ? 
ATOM   2846 C C   . ALA A 1 358 ? 41.870 23.244 22.528  1.000 30.880 0  358  ALA A C   1 ? 
ATOM   2847 O O   . ALA A 1 358 ? 41.444 23.698 21.471  1.000 30.500 0  358  ALA A O   1 ? 
ATOM   2848 C CB  . ALA A 1 358 ? 42.629 20.876 22.483  1.000 33.790 0  358  ALA A CB  1 ? 
ATOM   2849 N N   . GLY A 1 359 ? 42.704 23.904 23.351  1.000 27.220 0  359  GLY A N   1 ? 
ATOM   2850 C CA  . GLY A 1 359 ? 43.336 25.148 22.969  1.000 28.160 0  359  GLY A CA  1 ? 
ATOM   2851 C C   . GLY A 1 359 ? 43.103 26.264 23.974  1.000 26.500 0  359  GLY A C   1 ? 
ATOM   2852 O O   . GLY A 1 359 ? 43.642 27.349 23.779  1.000 31.330 0  359  GLY A O   1 ? 
ATOM   2853 N N   . ALA A 1 360 ? 42.232 26.050 24.982  1.000 24.950 0  360  ALA A N   1 ? 
ATOM   2854 C CA  . ALA A 1 360 ? 41.888 27.153 25.891  1.000 25.420 0  360  ALA A CA  1 ? 
ATOM   2855 C C   . ALA A 1 360 ? 42.585 26.976 27.238  1.000 27.530 0  360  ALA A C   1 ? 
ATOM   2856 O O   . ALA A 1 360 ? 42.311 27.719 28.191  1.000 22.280 0  360  ALA A O   1 ? 
ATOM   2857 C CB  . ALA A 1 360 ? 40.382 27.319 26.046  1.000 25.980 0  360  ALA A CB  1 ? 
ATOM   2858 N N   . GLU A 1 361 ? 43.576 26.066 27.245  1.000 24.610 0  361  GLU A N   1 ? 
ATOM   2859 C CA  . GLU A 1 361 ? 44.543 25.952 28.331  1.000 32.770 0  361  GLU A CA  1 ? 
ATOM   2860 C C   . GLU A 1 361 ? 45.340 27.257 28.482  1.000 31.620 0  361  GLU A C   1 ? 
ATOM   2861 O O   . GLU A 1 361 ? 45.849 27.542 29.566  1.000 30.630 0  361  GLU A O   1 ? 
ATOM   2862 C CB  . GLU A 1 361 ? 45.511 24.797 28.015  1.000 38.810 0  361  GLU A CB  1 ? 
ATOM   2863 C CG  . GLU A 1 361 ? 44.877 23.402 27.925  1.000 44.790 0  361  GLU A CG  1 ? 
ATOM   2864 C CD  . GLU A 1 361 ? 43.958 23.057 26.746  1.000 52.470 0  361  GLU A CD  1 ? 
ATOM   2865 O OE1 . GLU A 1 361 ? 42.887 22.396 26.952  1.000 51.680 0  361  GLU A OE1 1 ? 
ATOM   2866 O OE2 . GLU A 1 361 ? 44.302 23.491 25.617  1.000 50.850 0  361  GLU A OE2 1 ? 
ATOM   2867 N N   . GLU A 1 362 ? 45.487 28.015 27.378  1.000 34.660 0  362  GLU A N   1 ? 
ATOM   2868 C CA  . GLU A 1 362 ? 46.122 29.336 27.357  1.000 38.770 0  362  GLU A CA  1 ? 
ATOM   2869 C C   . GLU A 1 362 ? 45.171 30.408 26.804  1.000 45.760 0  362  GLU A C   1 ? 
ATOM   2870 O O   . GLU A 1 362 ? 44.947 30.445 25.598  1.000 49.520 0  362  GLU A O   1 ? 
ATOM   2871 C CB  . GLU A 1 362 ? 47.342 29.321 26.438  1.000 47.540 0  362  GLU A CB  1 ? 
ATOM   2872 C CG  . GLU A 1 362 ? 48.445 28.362 26.880  1.000 51.460 0  362  GLU A CG  1 ? 
ATOM   2873 C CD  . GLU A 1 362 ? 49.765 28.644 26.166  1.000 63.300 0  362  GLU A CD  1 ? 
ATOM   2874 O OE1 . GLU A 1 362 ? 49.834 29.625 25.378  1.000 64.360 0  362  GLU A OE1 1 ? 
ATOM   2875 O OE2 . GLU A 1 362 ? 50.730 27.885 26.398  1.000 62.320 0  362  GLU A OE2 1 ? 
ATOM   2876 N N   . LEU A 1 363 ? 44.675 31.293 27.697  1.000 48.630 0  363  LEU A N   1 ? 
ATOM   2877 C CA  . LEU A 1 363 ? 43.544 32.219 27.533  1.000 49.040 0  363  LEU A CA  1 ? 
ATOM   2878 C C   . LEU A 1 363 ? 42.150 31.517 27.410  1.000 47.710 0  363  LEU A C   1 ? 
ATOM   2879 O O   . LEU A 1 363 ? 41.556 31.421 26.272  1.000 47.220 0  363  LEU A O   1 ? 
ATOM   2880 C CB  . LEU A 1 363 ? 43.830 33.253 26.446  1.000 55.010 0  363  LEU A CB  1 ? 
ATOM   2881 C CG  . LEU A 1 363 ? 44.416 34.591 26.923  1.000 53.350 0  363  LEU A CG  1 ? 
ATOM   2882 C CD1 . LEU A 1 363 ? 45.940 34.648 26.810  1.000 52.780 0  363  LEU A CD1 1 ? 
ATOM   2883 C CD2 . LEU A 1 363 ? 43.760 35.761 26.190  1.000 51.160 0  363  LEU A CD2 1 ? 
ATOM   2884 O OXT . LEU A 1 363 ? 41.616 31.149 28.494  1.000 51.400 0  363  LEU A OXT 1 ? 
ATOM   2885 N N   . ASP B 2 1   ? 3.933  3.008  -16.702 1.000 64.250 0  956  ASP D N   1 ? 
ATOM   2886 C CA  . ASP B 2 1   ? 5.042  3.855  -17.221 1.000 62.810 0  956  ASP D CA  1 ? 
ATOM   2887 C C   . ASP B 2 1   ? 6.043  4.061  -16.092 1.000 49.130 0  956  ASP D C   1 ? 
ATOM   2888 O O   . ASP B 2 1   ? 5.752  4.791  -15.153 1.000 50.830 0  956  ASP D O   1 ? 
ATOM   2889 C CB  . ASP B 2 1   ? 4.537  5.205  -17.719 1.000 75.960 0  956  ASP D CB  1 ? 
ATOM   2890 C CG  . ASP B 2 1   ? 3.841  6.086  -16.682 1.000 90.080 0  956  ASP D CG  1 ? 
ATOM   2891 O OD1 . ASP B 2 1   ? 2.758  5.680  -16.204 1.000 95.620 0  956  ASP D OD1 1 ? 
ATOM   2892 O OD2 . ASP B 2 1   ? 4.390  7.170  -16.344 1.000 88.150 0  956  ASP D OD2 1 ? 
ATOM   2893 N N   . GLN B 2 2   ? 7.202  3.414  -16.176 1.000 38.980 0  957  GLN D N   1 ? 
ATOM   2894 C CA  . GLN B 2 2   ? 8.228  3.605  -15.167 1.000 36.990 0  957  GLN D CA  1 ? 
ATOM   2895 C C   . GLN B 2 2   ? 9.077  4.826  -15.550 1.000 33.850 0  957  GLN D C   1 ? 
ATOM   2896 O O   . GLN B 2 2   ? 9.411  5.032  -16.716 1.000 27.030 0  957  GLN D O   1 ? 
ATOM   2897 C CB  . GLN B 2 2   ? 9.017  2.310  -14.984 1.000 41.940 0  957  GLN D CB  1 ? 
ATOM   2898 C CG  . GLN B 2 2   ? 9.495  1.703  -16.299 1.000 51.740 0  957  GLN D CG  1 ? 
ATOM   2899 C CD  . GLN B 2 2   ? 10.278 0.422  -16.117 1.000 65.050 0  957  GLN D CD  1 ? 
ATOM   2900 O OE1 . GLN B 2 2   ? 10.021 -0.358 -15.189 1.000 69.480 0  957  GLN D OE1 1 ? 
ATOM   2901 N NE2 . GLN B 2 2   ? 11.258 0.214  -16.990 1.000 63.510 0  957  GLN D NE2 1 ? 
ATOM   2902 N N   . LEU B 2 3   ? 9.443  5.645  -14.549 1.000 25.990 0  958  LEU D N   1 ? 
ATOM   2903 C CA  . LEU B 2 3   ? 10.182 6.881  -14.822 1.000 24.620 0  958  LEU D CA  1 ? 
ATOM   2904 C C   . LEU B 2 3   ? 11.682 6.626  -14.930 1.000 25.890 0  958  LEU D C   1 ? 
ATOM   2905 O O   . LEU B 2 3   ? 12.430 7.532  -15.253 1.000 27.160 0  958  LEU D O   1 ? 
ATOM   2906 C CB  . LEU B 2 3   ? 9.853  7.914  -13.743 1.000 25.060 0  958  LEU D CB  1 ? 
ATOM   2907 C CG  . LEU B 2 3   ? 8.428  8.473  -13.741 1.000 26.370 0  958  LEU D CG  1 ? 
ATOM   2908 C CD1 . LEU B 2 3   ? 8.245  9.520  -12.630 1.000 23.330 0  958  LEU D CD1 1 ? 
ATOM   2909 C CD2 . LEU B 2 3   ? 8.060  9.082  -15.096 1.000 31.640 0  958  LEU D CD2 1 ? 
ATOM   2910 N N   . ILE B 2 4   ? 12.137 5.411  -14.602 1.000 24.540 0  959  ILE D N   1 ? 
ATOM   2911 C CA  . ILE B 2 4   ? 13.520 4.997  -14.746 1.000 25.330 0  959  ILE D CA  1 ? 
ATOM   2912 C C   . ILE B 2 4   ? 13.476 3.555  -15.242 1.000 27.420 0  959  ILE D C   1 ? 
ATOM   2913 O O   . ILE B 2 4   ? 12.587 2.800  -14.827 1.000 28.880 0  959  ILE D O   1 ? 
ATOM   2914 C CB  . ILE B 2 4   ? 14.297 5.105  -13.412 1.000 22.710 0  959  ILE D CB  1 ? 
ATOM   2915 C CG1 . ILE B 2 4   ? 15.784 4.854  -13.571 1.000 23.860 0  959  ILE D CG1 1 ? 
ATOM   2916 C CG2 . ILE B 2 4   ? 13.717 4.152  -12.356 1.000 26.290 0  959  ILE D CG2 1 ? 
ATOM   2917 C CD1 . ILE B 2 4   ? 16.619 5.357  -12.396 1.000 23.380 0  959  ILE D CD1 1 ? 
ATOM   2918 N N   . ASP B 2 5   ? 14.480 3.176  -16.040 1.000 28.240 0  960  ASP D N   1 ? 
ATOM   2919 C CA  . ASP B 2 5   ? 14.617 1.815  -16.546 1.000 31.080 0  960  ASP D CA  1 ? 
ATOM   2920 C C   . ASP B 2 5   ? 15.771 1.129  -15.819 1.000 28.130 0  960  ASP D C   1 ? 
ATOM   2921 O O   . ASP B 2 5   ? 16.923 1.467  -16.037 1.000 27.660 0  960  ASP D O   1 ? 
ATOM   2922 C CB  . ASP B 2 5   ? 14.831 1.819  -18.057 1.000 36.410 0  960  ASP D CB  1 ? 
ATOM   2923 C CG  . ASP B 2 5   ? 13.646 2.276  -18.900 1.000 42.870 0  960  ASP D CG  1 ? 
ATOM   2924 O OD1 . ASP B 2 5   ? 12.507 2.286  -18.383 1.000 52.070 0  960  ASP D OD1 1 ? 
ATOM   2925 O OD2 . ASP B 2 5   ? 13.872 2.629  -20.080 1.000 50.200 -1 960  ASP D OD2 1 ? 
ATOM   2926 N N   . LEU B 2 6   ? 15.467 0.222  -14.887 1.000 29.060 0  961  LEU D N   1 ? 
ATOM   2927 C CA  . LEU B 2 6   ? 16.523 -0.415 -14.103 1.000 34.410 0  961  LEU D CA  1 ? 
ATOM   2928 C C   . LEU B 2 6   ? 16.882 -1.824 -14.624 1.000 38.540 0  961  LEU D C   1 ? 
ATOM   2929 O O   . LEU B 2 6   ? 17.982 -2.326 -14.242 1.000 43.690 0  961  LEU D O   1 ? 
ATOM   2930 C CB  . LEU B 2 6   ? 16.060 -0.463 -12.651 1.000 33.050 0  961  LEU D CB  1 ? 
ATOM   2931 C CG  . LEU B 2 6   ? 15.869 0.918  -12.007 1.000 32.090 0  961  LEU D CG  1 ? 
ATOM   2932 C CD1 . LEU B 2 6   ? 15.197 0.775  -10.663 1.000 31.730 0  961  LEU D CD1 1 ? 
ATOM   2933 C CD2 . LEU B 2 6   ? 17.224 1.586  -11.875 1.000 33.400 0  961  LEU D CD2 1 ? 
ATOM   2934 O OXT . LEU B 2 6   ? 16.046 -2.383 -15.329 1.000 43.330 0  961  LEU D OXT 1 ? 
ATOM   2935 N N   . ASP C 2 1   ? -0.379 35.854 12.343  1.000 76.550 0  956  ASP E N   1 ? 
ATOM   2936 C CA  . ASP C 2 1   ? 0.884  35.125 12.659  1.000 74.200 0  956  ASP E CA  1 ? 
ATOM   2937 C C   . ASP C 2 1   ? 1.216  35.327 14.137  1.000 67.370 0  956  ASP E C   1 ? 
ATOM   2938 O O   . ASP C 2 1   ? 0.392  35.018 14.998  1.000 63.880 0  956  ASP E O   1 ? 
ATOM   2939 C CB  . ASP C 2 1   ? 2.022  35.462 11.695  1.000 66.880 0  956  ASP E CB  1 ? 
ATOM   2940 C CG  . ASP C 2 1   ? 2.196  36.909 11.231  1.000 64.860 0  956  ASP E CG  1 ? 
ATOM   2941 O OD1 . ASP C 2 1   ? 1.516  37.318 10.266  1.000 68.170 0  956  ASP E OD1 1 ? 
ATOM   2942 O OD2 . ASP C 2 1   ? 3.030  37.621 11.814  1.000 69.220 0  956  ASP E OD2 1 ? 
ATOM   2943 N N   . GLN C 2 2   ? 2.402  35.907 14.385  1.000 55.220 0  957  GLN E N   1 ? 
ATOM   2944 C CA  . GLN C 2 2   ? 3.076  35.912 15.668  1.000 45.890 0  957  GLN E CA  1 ? 
ATOM   2945 C C   . GLN C 2 2   ? 3.467  34.502 16.074  1.000 35.820 0  957  GLN E C   1 ? 
ATOM   2946 O O   . GLN C 2 2   ? 3.199  34.095 17.198  1.000 34.410 0  957  GLN E O   1 ? 
ATOM   2947 C CB  . GLN C 2 2   ? 2.303  36.670 16.745  1.000 56.500 0  957  GLN E CB  1 ? 
ATOM   2948 C CG  . GLN C 2 2   ? 2.314  38.172 16.487  1.000 74.290 0  957  GLN E CG  1 ? 
ATOM   2949 C CD  . GLN C 2 2   ? 3.579  38.592 15.769  1.000 78.250 0  957  GLN E CD  1 ? 
ATOM   2950 O OE1 . GLN C 2 2   ? 3.605  38.753 14.543  1.000 76.790 0  957  GLN E OE1 1 ? 
ATOM   2951 N NE2 . GLN C 2 2   ? 4.668  38.669 16.519  1.000 78.660 0  957  GLN E NE2 1 ? 
ATOM   2952 N N   . LEU C 2 3   ? 4.242  33.820 15.213  1.000 23.460 0  958  LEU E N   1 ? 
ATOM   2953 C CA  . LEU C 2 3   ? 4.892  32.612 15.657  1.000 22.090 0  958  LEU E CA  1 ? 
ATOM   2954 C C   . LEU C 2 3   ? 6.108  32.967 16.465  1.000 24.640 0  958  LEU E C   1 ? 
ATOM   2955 O O   . LEU C 2 3   ? 6.366  32.304 17.449  1.000 29.200 0  958  LEU E O   1 ? 
ATOM   2956 C CB  . LEU C 2 3   ? 5.274  31.694 14.503  1.000 19.600 0  958  LEU E CB  1 ? 
ATOM   2957 C CG  . LEU C 2 3   ? 4.079  31.090 13.766  1.000 19.590 0  958  LEU E CG  1 ? 
ATOM   2958 C CD1 . LEU C 2 3   ? 4.487  30.232 12.585  1.000 18.020 0  958  LEU E CD1 1 ? 
ATOM   2959 C CD2 . LEU C 2 3   ? 3.266  30.248 14.730  1.000 20.240 0  958  LEU E CD2 1 ? 
ATOM   2960 N N   . ILE C 2 4   ? 6.864  33.952 15.985  1.000 27.500 0  959  ILE E N   1 ? 
ATOM   2961 C CA  . ILE C 2 4   ? 8.076  34.410 16.646  1.000 28.360 0  959  ILE E CA  1 ? 
ATOM   2962 C C   . ILE C 2 4   ? 8.102  35.943 16.590  1.000 32.210 0  959  ILE E C   1 ? 
ATOM   2963 O O   . ILE C 2 4   ? 7.508  36.559 15.702  1.000 28.300 0  959  ILE E O   1 ? 
ATOM   2964 C CB  . ILE C 2 4   ? 9.300  33.783 15.969  1.000 30.010 0  959  ILE E CB  1 ? 
ATOM   2965 C CG1 . ILE C 2 4   ? 9.350  34.144 14.526  1.000 29.640 0  959  ILE E CG1 1 ? 
ATOM   2966 C CG2 . ILE C 2 4   ? 9.305  32.268 16.188  1.000 37.530 0  959  ILE E CG2 1 ? 
ATOM   2967 C CD1 . ILE C 2 4   ? 10.635 33.755 13.831  1.000 34.450 0  959  ILE E CD1 1 ? 
ATOM   2968 N N   . ASP C 2 5   ? 8.838  36.562 17.510  1.000 37.440 0  960  ASP E N   1 ? 
ATOM   2969 C CA  . ASP C 2 5   ? 8.846  38.012 17.585  1.000 43.370 0  960  ASP E CA  1 ? 
ATOM   2970 C C   . ASP C 2 5   ? 10.264 38.489 17.346  1.000 45.120 0  960  ASP E C   1 ? 
ATOM   2971 O O   . ASP C 2 5   ? 11.076 38.455 18.259  1.000 42.000 0  960  ASP E O   1 ? 
ATOM   2972 C CB  . ASP C 2 5   ? 8.246  38.494 18.898  1.000 54.570 0  960  ASP E CB  1 ? 
ATOM   2973 C CG  . ASP C 2 5   ? 6.730  38.647 18.858  1.000 67.090 0  960  ASP E CG  1 ? 
ATOM   2974 O OD1 . ASP C 2 5   ? 6.261  39.694 18.357  1.000 74.830 0  960  ASP E OD1 1 ? 
ATOM   2975 O OD2 . ASP C 2 5   ? 6.020  37.693 19.257  1.000 71.500 0  960  ASP E OD2 1 ? 
ATOM   2976 N N   . LEU C 2 6   ? 10.537 38.942 16.122  1.000 48.000 0  961  LEU E N   1 ? 
ATOM   2977 C CA  . LEU C 2 6   ? 11.899 39.281 15.747  1.000 60.850 0  961  LEU E CA  1 ? 
ATOM   2978 C C   . LEU C 2 6   ? 12.198 40.756 16.085  1.000 70.780 0  961  LEU E C   1 ? 
ATOM   2979 O O   . LEU C 2 6   ? 11.582 41.645 15.441  1.000 79.470 0  961  LEU E O   1 ? 
ATOM   2980 C CB  . LEU C 2 6   ? 12.061 38.942 14.270  1.000 62.000 0  961  LEU E CB  1 ? 
ATOM   2981 C CG  . LEU C 2 6   ? 11.776 37.475 13.945  1.000 56.680 0  961  LEU E CG  1 ? 
ATOM   2982 C CD1 . LEU C 2 6   ? 11.129 37.353 12.591  1.000 57.930 0  961  LEU E CD1 1 ? 
ATOM   2983 C CD2 . LEU C 2 6   ? 13.068 36.677 14.036  1.000 56.610 0  961  LEU E CD2 1 ? 
ATOM   2984 O OXT . LEU C 2 6   ? 13.027 40.958 17.006  1.000 69.340 0  961  LEU E OXT 1 ? 
HETATM 2985 O O   . HOH D 3 .   ? 31.037 33.457 27.747  1.000 46.550 0  401  HOH A O   1 ? 
HETATM 2986 O O   . HOH D 3 .   ? 9.476  2.220  11.467  1.000 50.190 0  402  HOH A O   1 ? 
HETATM 2987 O O   . HOH D 3 .   ? 42.985 22.130 8.637   1.000 66.060 0  403  HOH A O   1 ? 
HETATM 2988 O O   . HOH D 3 .   ? 22.607 37.378 -8.258  1.000 40.510 0  404  HOH A O   1 ? 
HETATM 2989 O O   . HOH D 3 .   ? 27.076 24.171 28.300  1.000 35.220 0  405  HOH A O   1 ? 
HETATM 2990 O O   . HOH D 3 .   ? 5.296  30.386 23.631  1.000 39.130 0  406  HOH A O   1 ? 
HETATM 2991 O O   . HOH D 3 .   ? 36.681 39.737 18.571  1.000 42.090 0  407  HOH A O   1 ? 
HETATM 2992 O O   . HOH D 3 .   ? 54.145 33.960 6.709   1.000 30.000 0  408  HOH A O   1 ? 
HETATM 2993 O O   . HOH D 3 .   ? -4.485 18.816 -1.726  1.000 36.610 0  409  HOH A O   1 ? 
HETATM 2994 O O   . HOH D 3 .   ? 0.436  9.656  -13.329 1.000 43.100 0  410  HOH A O   1 ? 
HETATM 2995 O O   . HOH D 3 .   ? 13.085 6.602  9.238   1.000 43.350 0  411  HOH A O   1 ? 
HETATM 2996 O O   . HOH D 3 .   ? 48.042 32.499 13.565  1.000 52.250 0  412  HOH A O   1 ? 
HETATM 2997 O O   . HOH D 3 .   ? -3.853 14.046 -10.949 1.000 36.760 0  413  HOH A O   1 ? 
HETATM 2998 O O   . HOH D 3 .   ? 25.894 4.531  -8.307  1.000 43.350 0  414  HOH A O   1 ? 
HETATM 2999 O O   . HOH D 3 .   ? 46.828 28.228 31.783  1.000 49.720 0  415  HOH A O   1 ? 
HETATM 3000 O O   . HOH D 3 .   ? 55.549 35.374 9.085   1.000 41.800 0  416  HOH A O   1 ? 
HETATM 3001 O O   . HOH D 3 .   ? 22.392 20.351 11.475  1.000 35.580 0  417  HOH A O   1 ? 
HETATM 3002 O O   . HOH D 3 .   ? 46.017 30.947 6.256   1.000 44.880 0  418  HOH A O   1 ? 
HETATM 3003 O O   . HOH D 3 .   ? 10.544 21.167 18.047  1.000 38.710 0  419  HOH A O   1 ? 
HETATM 3004 O O   . HOH D 3 .   ? 32.772 16.479 -18.501 1.000 45.690 0  420  HOH A O   1 ? 
HETATM 3005 O O   . HOH D 3 .   ? -3.396 28.779 9.421   1.000 42.320 0  421  HOH A O   1 ? 
HETATM 3006 O O   . HOH D 3 .   ? 21.603 44.019 -2.644  1.000 40.050 0  422  HOH A O   1 ? 
HETATM 3007 O O   . HOH D 3 .   ? 36.854 38.274 25.437  1.000 37.800 0  423  HOH A O   1 ? 
HETATM 3008 O O   . HOH D 3 .   ? 7.478  23.292 24.592  1.000 54.730 0  424  HOH A O   1 ? 
HETATM 3009 O O   . HOH D 3 .   ? 17.024 33.098 29.143  1.000 30.990 0  425  HOH A O   1 ? 
HETATM 3010 O O   . HOH D 3 .   ? 12.774 17.550 31.743  1.000 52.610 0  426  HOH A O   1 ? 
HETATM 3011 O O   . HOH D 3 .   ? 39.369 30.452 -4.911  1.000 61.580 0  427  HOH A O   1 ? 
HETATM 3012 O O   . HOH D 3 .   ? 20.916 43.673 -6.035  1.000 29.160 0  428  HOH A O   1 ? 
HETATM 3013 O O   . HOH D 3 .   ? 28.331 39.842 12.589  1.000 34.280 0  429  HOH A O   1 ? 
HETATM 3014 O O   . HOH D 3 .   ? 20.798 -5.281 -7.971  1.000 34.980 0  430  HOH A O   1 ? 
HETATM 3015 O O   . HOH D 3 .   ? 35.951 27.651 -10.635 1.000 45.150 0  431  HOH A O   1 ? 
HETATM 3016 O O   . HOH D 3 .   ? 32.891 29.316 -4.422  1.000 40.860 0  432  HOH A O   1 ? 
HETATM 3017 O O   . HOH D 3 .   ? 15.717 18.718 -3.643  1.000 20.510 0  433  HOH A O   1 ? 
HETATM 3018 O O   . HOH D 3 .   ? 8.117  26.755 29.442  1.000 37.480 0  434  HOH A O   1 ? 
HETATM 3019 O O   . HOH D 3 .   ? 27.611 24.921 -14.772 1.000 36.500 0  435  HOH A O   1 ? 
HETATM 3020 O O   . HOH D 3 .   ? 34.451 19.490 -12.276 1.000 26.590 0  436  HOH A O   1 ? 
HETATM 3021 O O   . HOH D 3 .   ? 23.544 21.367 19.919  1.000 25.470 0  437  HOH A O   1 ? 
HETATM 3022 O O   . HOH D 3 .   ? 18.959 0.075  -3.496  1.000 29.940 0  438  HOH A O   1 ? 
HETATM 3023 O O   . HOH D 3 .   ? 10.233 32.921 19.620  1.000 42.840 0  439  HOH A O   1 ? 
HETATM 3024 O O   . HOH D 3 .   ? 21.463 22.691 -14.796 1.000 41.670 0  440  HOH A O   1 ? 
HETATM 3025 O O   . HOH D 3 .   ? -6.129 21.649 -8.309  1.000 41.900 0  441  HOH A O   1 ? 
HETATM 3026 O O   . HOH D 3 .   ? 6.067  29.707 -6.973  1.000 24.870 0  442  HOH A O   1 ? 
HETATM 3027 O O   . HOH D 3 .   ? 21.552 -1.586 0.299   1.000 36.500 0  443  HOH A O   1 ? 
HETATM 3028 O O   . HOH D 3 .   ? 14.055 17.818 8.337   1.000 33.350 0  444  HOH A O   1 ? 
HETATM 3029 O O   . HOH D 3 .   ? 10.093 30.843 22.118  1.000 38.510 0  445  HOH A O   1 ? 
HETATM 3030 O O   . HOH D 3 .   ? 24.370 14.611 4.338   1.000 24.040 0  446  HOH A O   1 ? 
HETATM 3031 O O   . HOH D 3 .   ? 20.586 19.344 -0.230  1.000 32.940 0  447  HOH A O   1 ? 
HETATM 3032 O O   . HOH D 3 .   ? 25.159 43.876 6.172   1.000 39.410 0  448  HOH A O   1 ? 
HETATM 3033 O O   . HOH D 3 .   ? -1.701 21.378 -4.232  1.000 25.950 0  449  HOH A O   1 ? 
HETATM 3034 O O   . HOH D 3 .   ? 32.812 18.866 19.524  1.000 41.270 0  450  HOH A O   1 ? 
HETATM 3035 O O   . HOH D 3 .   ? 13.511 39.480 8.009   1.000 26.620 0  451  HOH A O   1 ? 
HETATM 3036 O O   . HOH D 3 .   ? 4.419  26.795 -11.299 1.000 46.670 0  452  HOH A O   1 ? 
HETATM 3037 O O   . HOH D 3 .   ? 30.395 12.165 5.470   1.000 30.610 0  453  HOH A O   1 ? 
HETATM 3038 O O   . HOH D 3 .   ? 35.494 5.109  -6.835  1.000 45.910 0  454  HOH A O   1 ? 
HETATM 3039 O O   . HOH D 3 .   ? 5.000  23.213 18.592  1.000 27.250 0  455  HOH A O   1 ? 
HETATM 3040 O O   . HOH D 3 .   ? 16.191 45.671 5.587   1.000 53.510 0  456  HOH A O   1 ? 
HETATM 3041 O O   . HOH D 3 .   ? 13.981 44.541 3.836   1.000 34.700 0  457  HOH A O   1 ? 
HETATM 3042 O O   . HOH D 3 .   ? 43.325 29.919 23.411  1.000 34.750 0  458  HOH A O   1 ? 
HETATM 3043 O O   . HOH D 3 .   ? 21.794 24.619 0.509   1.000 29.890 0  459  HOH A O   1 ? 
HETATM 3044 O O   . HOH D 3 .   ? 15.409 39.479 1.080   1.000 20.530 0  460  HOH A O   1 ? 
HETATM 3045 O O   . HOH D 3 .   ? 35.502 40.679 -1.134  1.000 48.570 0  461  HOH A O   1 ? 
HETATM 3046 O O   . HOH D 3 .   ? 12.413 25.073 22.313  1.000 22.440 0  462  HOH A O   1 ? 
HETATM 3047 O O   . HOH D 3 .   ? 20.403 15.579 4.174   1.000 34.630 0  463  HOH A O   1 ? 
HETATM 3048 O O   . HOH D 3 .   ? -1.080 28.598 7.107   1.000 23.650 0  464  HOH A O   1 ? 
HETATM 3049 O O   . HOH D 3 .   ? 22.121 39.481 -7.111  1.000 30.030 0  465  HOH A O   1 ? 
HETATM 3050 O O   . HOH D 3 .   ? 33.962 32.371 28.577  1.000 28.780 0  466  HOH A O   1 ? 
HETATM 3051 O O   . HOH D 3 .   ? 0.739  37.416 -3.558  1.000 43.910 0  467  HOH A O   1 ? 
HETATM 3052 O O   . HOH D 3 .   ? 21.668 12.910 -3.121  1.000 18.940 0  468  HOH A O   1 ? 
HETATM 3053 O O   . HOH D 3 .   ? 19.912 21.326 -6.948  1.000 27.510 0  469  HOH A O   1 ? 
HETATM 3054 O O   . HOH D 3 .   ? 9.690  25.961 33.024  1.000 57.640 0  470  HOH A O   1 ? 
HETATM 3055 O O   . HOH D 3 .   ? 13.789 44.054 -10.144 1.000 33.370 0  471  HOH A O   1 ? 
HETATM 3056 O O   . HOH D 3 .   ? 41.838 35.406 9.532   1.000 35.620 0  472  HOH A O   1 ? 
HETATM 3057 O O   . HOH D 3 .   ? -1.827 20.259 14.824  1.000 53.570 0  473  HOH A O   1 ? 
HETATM 3058 O O   . HOH D 3 .   ? 20.912 21.416 13.050  1.000 39.020 0  474  HOH A O   1 ? 
HETATM 3059 O O   . HOH D 3 .   ? 12.240 25.308 -7.718  1.000 23.510 0  475  HOH A O   1 ? 
HETATM 3060 O O   . HOH D 3 .   ? 26.690 20.458 20.907  1.000 34.810 0  476  HOH A O   1 ? 
HETATM 3061 O O   . HOH D 3 .   ? 25.948 2.871  -15.799 1.000 36.770 0  477  HOH A O   1 ? 
HETATM 3062 O O   . HOH D 3 .   ? 22.079 21.396 30.452  1.000 31.500 0  478  HOH A O   1 ? 
HETATM 3063 O O   . HOH D 3 .   ? 13.487 33.699 24.567  1.000 41.460 0  479  HOH A O   1 ? 
HETATM 3064 O O   . HOH D 3 .   ? 7.184  15.065 16.390  1.000 42.880 0  480  HOH A O   1 ? 
HETATM 3065 O O   . HOH D 3 .   ? 27.772 45.545 -0.242  1.000 31.010 0  481  HOH A O   1 ? 
HETATM 3066 O O   . HOH D 3 .   ? 42.567 24.999 7.936   1.000 36.640 0  482  HOH A O   1 ? 
HETATM 3067 O O   . HOH D 3 .   ? 13.347 26.620 3.559   1.000 18.670 0  483  HOH A O   1 ? 
HETATM 3068 O O   . HOH D 3 .   ? 1.325  22.962 -8.796  1.000 23.320 0  484  HOH A O   1 ? 
HETATM 3069 O O   . HOH D 3 .   ? 17.878 43.523 6.960   1.000 46.960 0  485  HOH A O   1 ? 
HETATM 3070 O O   . HOH D 3 .   ? 27.966 2.601  -1.165  1.000 57.600 0  486  HOH A O   1 ? 
HETATM 3071 O O   . HOH D 3 .   ? 24.578 38.431 19.863  1.000 34.570 0  487  HOH A O   1 ? 
HETATM 3072 O O   . HOH D 3 .   ? 30.081 47.019 2.954   1.000 39.800 0  488  HOH A O   1 ? 
HETATM 3073 O O   . HOH D 3 .   ? 37.734 17.905 5.616   1.000 40.110 0  489  HOH A O   1 ? 
HETATM 3074 O O   . HOH D 3 .   ? 6.566  38.525 -1.100  1.000 42.290 0  490  HOH A O   1 ? 
HETATM 3075 O O   . HOH D 3 .   ? 0.187  18.477 16.245  1.000 57.820 0  491  HOH A O   1 ? 
HETATM 3076 O O   . HOH D 3 .   ? 14.847 10.208 -23.661 1.000 52.030 0  492  HOH A O   1 ? 
HETATM 3077 O O   . HOH D 3 .   ? 40.869 24.259 18.824  1.000 21.030 0  493  HOH A O   1 ? 
HETATM 3078 O O   . HOH D 3 .   ? 15.283 18.431 -9.394  1.000 35.260 0  494  HOH A O   1 ? 
HETATM 3079 O O   . HOH D 3 .   ? 27.483 6.725  -0.622  1.000 29.690 0  495  HOH A O   1 ? 
HETATM 3080 O O   . HOH D 3 .   ? 4.631  16.504 11.686  1.000 28.240 0  496  HOH A O   1 ? 
HETATM 3081 O O   . HOH D 3 .   ? 33.733 38.467 15.837  1.000 27.670 0  497  HOH A O   1 ? 
HETATM 3082 O O   . HOH D 3 .   ? 35.772 34.046 29.945  1.000 27.490 0  498  HOH A O   1 ? 
HETATM 3083 O O   . HOH D 3 .   ? 16.078 27.849 3.845   1.000 37.810 0  499  HOH A O   1 ? 
HETATM 3084 O O   . HOH D 3 .   ? -0.095 6.465  -3.543  1.000 39.770 0  500  HOH A O   1 ? 
HETATM 3085 O O   . HOH D 3 .   ? 24.778 10.967 5.465   1.000 49.350 0  501  HOH A O   1 ? 
HETATM 3086 O O   . HOH D 3 .   ? 14.669 26.630 26.068  1.000 16.520 0  502  HOH A O   1 ? 
HETATM 3087 O O   . HOH D 3 .   ? 18.235 38.553 23.534  1.000 28.440 0  503  HOH A O   1 ? 
HETATM 3088 O O   . HOH D 3 .   ? 15.620 20.828 15.104  1.000 21.140 0  504  HOH A O   1 ? 
HETATM 3089 O O   . HOH D 3 .   ? 17.844 0.000  0.000   0.500 48.190 0  505  HOH A O   1 ? 
HETATM 3090 O O   . HOH D 3 .   ? 2.625  10.153 4.196   1.000 23.250 0  506  HOH A O   1 ? 
HETATM 3091 O O   . HOH D 3 .   ? 15.710 44.056 -12.074 1.000 33.870 0  507  HOH A O   1 ? 
HETATM 3092 O O   . HOH D 3 .   ? 19.978 23.977 -3.484  1.000 26.560 0  508  HOH A O   1 ? 
HETATM 3093 O O   . HOH D 3 .   ? 19.771 -1.822 -10.400 1.000 37.000 0  509  HOH A O   1 ? 
HETATM 3094 O O   . HOH D 3 .   ? 15.160 19.764 4.089   1.000 25.750 0  510  HOH A O   1 ? 
HETATM 3095 O O   . HOH D 3 .   ? 29.238 38.651 8.935   1.000 24.700 0  511  HOH A O   1 ? 
HETATM 3096 O O   . HOH D 3 .   ? 10.580 37.096 -3.046  1.000 22.740 0  512  HOH A O   1 ? 
HETATM 3097 O O   . HOH D 3 .   ? 11.662 31.235 23.976  1.000 35.200 0  513  HOH A O   1 ? 
HETATM 3098 O O   . HOH D 3 .   ? 14.693 33.149 21.223  1.000 16.430 0  514  HOH A O   1 ? 
HETATM 3099 O O   . HOH D 3 .   ? 25.833 22.861 23.446  1.000 29.800 0  515  HOH A O   1 ? 
HETATM 3100 O O   . HOH D 3 .   ? 16.039 19.204 11.076  1.000 40.750 0  516  HOH A O   1 ? 
HETATM 3101 O O   . HOH D 3 .   ? 4.522  23.660 16.031  1.000 18.530 0  517  HOH A O   1 ? 
HETATM 3102 O O   . HOH D 3 .   ? 37.313 17.402 11.212  1.000 44.250 0  518  HOH A O   1 ? 
HETATM 3103 O O   . HOH D 3 .   ? 28.718 30.375 -3.644  1.000 30.080 0  519  HOH A O   1 ? 
HETATM 3104 O O   . HOH D 3 .   ? 7.172  35.643 3.178   1.000 17.310 0  520  HOH A O   1 ? 
HETATM 3105 O O   . HOH D 3 .   ? 53.189 29.019 6.610   1.000 42.740 0  521  HOH A O   1 ? 
HETATM 3106 O O   . HOH D 3 .   ? 21.801 43.808 15.983  1.000 49.070 0  522  HOH A O   1 ? 
HETATM 3107 O O   . HOH D 3 .   ? 19.072 16.589 30.830  1.000 54.680 0  523  HOH A O   1 ? 
HETATM 3108 O O   . HOH D 3 .   ? 30.493 11.769 1.436   1.000 41.620 0  524  HOH A O   1 ? 
HETATM 3109 O O   . HOH D 3 .   ? -0.930 24.562 -10.141 1.000 54.780 0  525  HOH A O   1 ? 
HETATM 3110 O O   . HOH D 3 .   ? 30.151 38.431 2.794   1.000 27.580 0  526  HOH A O   1 ? 
HETATM 3111 O O   . HOH D 3 .   ? 10.423 11.228 9.108   1.000 30.790 0  527  HOH A O   1 ? 
HETATM 3112 O O   . HOH D 3 .   ? 9.840  25.057 21.965  1.000 35.650 0  528  HOH A O   1 ? 
HETATM 3113 O O   . HOH D 3 .   ? 19.512 18.599 -3.675  1.000 20.870 0  529  HOH A O   1 ? 
HETATM 3114 O O   . HOH D 3 .   ? 19.148 40.892 -1.705  1.000 24.680 0  530  HOH A O   1 ? 
HETATM 3115 O O   . HOH D 3 .   ? 6.795  -1.194 -1.477  1.000 35.540 0  531  HOH A O   1 ? 
HETATM 3116 O O   . HOH D 3 .   ? 34.481 16.792 13.860  1.000 64.240 0  532  HOH A O   1 ? 
HETATM 3117 O O   . HOH D 3 .   ? 18.776 32.631 -1.094  1.000 16.270 0  533  HOH A O   1 ? 
HETATM 3118 O O   . HOH D 3 .   ? 7.446  12.102 8.585   1.000 39.520 0  534  HOH A O   1 ? 
HETATM 3119 O O   . HOH D 3 .   ? 15.469 14.498 -17.535 1.000 52.950 0  535  HOH A O   1 ? 
HETATM 3120 O O   . HOH D 3 .   ? 26.714 19.342 9.623   1.000 32.700 0  536  HOH A O   1 ? 
HETATM 3121 O O   . HOH D 3 .   ? 25.408 24.415 25.759  1.000 27.190 0  537  HOH A O   1 ? 
HETATM 3122 O O   . HOH D 3 .   ? 12.883 14.718 11.105  1.000 29.370 0  538  HOH A O   1 ? 
HETATM 3123 O O   . HOH D 3 .   ? 16.283 41.074 9.548   1.000 35.080 0  539  HOH A O   1 ? 
HETATM 3124 O O   . HOH D 3 .   ? 17.923 24.305 26.307  1.000 17.310 0  540  HOH A O   1 ? 
HETATM 3125 O O   . HOH D 3 .   ? 32.386 21.314 11.609  1.000 24.360 0  541  HOH A O   1 ? 
HETATM 3126 O O   . HOH D 3 .   ? 41.752 23.856 4.513   1.000 38.620 0  542  HOH A O   1 ? 
HETATM 3127 O O   . HOH D 3 .   ? 18.623 26.159 -2.655  1.000 24.250 0  543  HOH A O   1 ? 
HETATM 3128 O O   . HOH D 3 .   ? -4.674 27.188 5.217   1.000 37.690 0  544  HOH A O   1 ? 
HETATM 3129 O O   . HOH D 3 .   ? 40.738 23.681 25.783  1.000 29.020 0  545  HOH A O   1 ? 
HETATM 3130 O O   . HOH D 3 .   ? 4.830  37.185 -3.854  1.000 43.040 0  546  HOH A O   1 ? 
HETATM 3131 O O   . HOH D 3 .   ? 6.672  18.499 -11.807 1.000 43.600 0  547  HOH A O   1 ? 
HETATM 3132 O O   . HOH D 3 .   ? -4.643 25.919 16.563  1.000 34.580 0  548  HOH A O   1 ? 
HETATM 3133 O O   . HOH D 3 .   ? 29.306 30.126 -10.782 1.000 45.820 0  549  HOH A O   1 ? 
HETATM 3134 O O   . HOH D 3 .   ? 7.260  38.299 10.234  1.000 30.510 0  550  HOH A O   1 ? 
HETATM 3135 O O   . HOH D 3 .   ? 32.737 27.397 -14.045 1.000 42.810 0  551  HOH A O   1 ? 
HETATM 3136 O O   . HOH D 3 .   ? 5.499  26.556 -7.366  1.000 32.410 0  552  HOH A O   1 ? 
HETATM 3137 O O   . HOH D 3 .   ? 29.758 38.866 0.176   1.000 23.430 0  553  HOH A O   1 ? 
HETATM 3138 O O   . HOH D 3 .   ? 44.184 23.616 19.999  1.000 38.220 0  554  HOH A O   1 ? 
HETATM 3139 O O   . HOH D 3 .   ? 29.208 31.030 22.991  1.000 30.080 0  555  HOH A O   1 ? 
HETATM 3140 O O   . HOH D 3 .   ? 21.407 11.236 -1.035  1.000 17.590 0  556  HOH A O   1 ? 
HETATM 3141 O O   . HOH D 3 .   ? 2.838  31.022 -2.485  1.000 18.250 0  557  HOH A O   1 ? 
HETATM 3142 O O   . HOH D 3 .   ? 5.444  15.226 9.201   1.000 26.490 0  558  HOH A O   1 ? 
HETATM 3143 O O   . HOH D 3 .   ? -2.718 24.160 7.721   1.000 24.640 0  559  HOH A O   1 ? 
HETATM 3144 O O   . HOH D 3 .   ? 3.236  3.326  -10.982 1.000 56.050 0  560  HOH A O   1 ? 
HETATM 3145 O O   . HOH D 3 .   ? 15.117 13.535 -27.079 1.000 56.910 0  561  HOH A O   1 ? 
HETATM 3146 O O   . HOH D 3 .   ? 31.391 36.862 21.527  1.000 35.050 0  562  HOH A O   1 ? 
HETATM 3147 O O   . HOH D 3 .   ? 22.438 33.202 25.212  1.000 39.490 0  563  HOH A O   1 ? 
HETATM 3148 O O   . HOH D 3 .   ? 1.856  15.115 -14.890 1.000 34.360 0  564  HOH A O   1 ? 
HETATM 3149 O O   . HOH D 3 .   ? -2.733 22.638 -10.933 1.000 52.690 0  565  HOH A O   1 ? 
HETATM 3150 O O   . HOH D 3 .   ? 1.250  38.563 0.776   1.000 48.940 0  566  HOH A O   1 ? 
HETATM 3151 O O   . HOH D 3 .   ? 21.682 22.343 9.280   1.000 18.180 0  567  HOH A O   1 ? 
HETATM 3152 O O   . HOH D 3 .   ? 17.549 16.668 1.492   1.000 29.280 0  568  HOH A O   1 ? 
HETATM 3153 O O   . HOH D 3 .   ? 10.537 45.267 -8.918  1.000 47.460 0  569  HOH A O   1 ? 
HETATM 3154 O O   . HOH D 3 .   ? 12.765 19.458 17.028  1.000 26.020 0  570  HOH A O   1 ? 
HETATM 3155 O O   . HOH D 3 .   ? 17.565 20.131 7.608   1.000 40.590 0  571  HOH A O   1 ? 
HETATM 3156 O O   . HOH D 3 .   ? 33.090 27.145 -4.953  1.000 45.100 0  572  HOH A O   1 ? 
HETATM 3157 O O   . HOH D 3 .   ? 36.411 14.423 5.052   1.000 45.150 0  573  HOH A O   1 ? 
HETATM 3158 O O   . HOH D 3 .   ? 17.082 23.181 -1.277  1.000 27.330 0  574  HOH A O   1 ? 
HETATM 3159 O O   . HOH D 3 .   ? 16.446 37.850 16.287  1.000 25.610 0  575  HOH A O   1 ? 
HETATM 3160 O O   . HOH D 3 .   ? 19.658 32.457 -6.401  1.000 31.060 0  576  HOH A O   1 ? 
HETATM 3161 O O   . HOH D 3 .   ? 20.879 21.118 -18.668 1.000 44.120 0  577  HOH A O   1 ? 
HETATM 3162 O O   . HOH D 3 .   ? 29.412 6.112  -8.248  1.000 28.740 0  578  HOH A O   1 ? 
HETATM 3163 O O   . HOH D 3 .   ? 41.206 19.115 -0.767  1.000 32.930 0  579  HOH A O   1 ? 
HETATM 3164 O O   . HOH D 3 .   ? 18.920 27.168 -0.283  1.000 40.460 0  580  HOH A O   1 ? 
HETATM 3165 O O   . HOH D 3 .   ? 7.893  20.369 28.166  1.000 44.770 0  581  HOH A O   1 ? 
HETATM 3166 O O   . HOH D 3 .   ? 33.857 15.370 22.321  1.000 54.660 0  582  HOH A O   1 ? 
HETATM 3167 O O   . HOH D 3 .   ? 8.166  23.505 19.543  1.000 45.920 0  583  HOH A O   1 ? 
HETATM 3168 O O   . HOH D 3 .   ? 35.214 19.085 12.054  1.000 32.220 0  584  HOH A O   1 ? 
HETATM 3169 O O   . HOH D 3 .   ? 10.014 38.836 1.378   1.000 19.910 0  585  HOH A O   1 ? 
HETATM 3170 O O   . HOH D 3 .   ? 26.272 42.306 14.761  1.000 30.100 0  586  HOH A O   1 ? 
HETATM 3171 O O   . HOH D 3 .   ? -2.830 10.925 2.664   1.000 49.150 0  587  HOH A O   1 ? 
HETATM 3172 O O   . HOH D 3 .   ? 40.187 20.125 19.726  1.000 30.860 0  588  HOH A O   1 ? 
HETATM 3173 O O   . HOH D 3 .   ? 0.149  30.124 -4.060  1.000 30.000 0  589  HOH A O   1 ? 
HETATM 3174 O O   . HOH D 3 .   ? 10.685 42.662 5.530   1.000 51.230 0  590  HOH A O   1 ? 
HETATM 3175 O O   . HOH D 3 .   ? -3.887 15.619 3.250   1.000 29.010 0  591  HOH A O   1 ? 
HETATM 3176 O O   . HOH D 3 .   ? 15.699 17.514 25.028  1.000 34.860 0  592  HOH A O   1 ? 
HETATM 3177 O O   . HOH D 3 .   ? -1.650 31.532 9.375   1.000 21.760 0  593  HOH A O   1 ? 
HETATM 3178 O O   . HOH D 3 .   ? 37.249 36.402 9.100   1.000 35.170 0  594  HOH A O   1 ? 
HETATM 3179 O O   . HOH D 3 .   ? 11.406 19.929 -9.442  1.000 29.270 0  595  HOH A O   1 ? 
HETATM 3180 O O   . HOH D 3 .   ? 23.568 21.444 22.666  1.000 20.600 0  596  HOH A O   1 ? 
HETATM 3181 O O   . HOH D 3 .   ? 33.587 11.197 -2.519  1.000 47.000 0  597  HOH A O   1 ? 
HETATM 3182 O O   . HOH D 3 .   ? -7.107 24.730 1.537   1.000 48.890 0  598  HOH A O   1 ? 
HETATM 3183 O O   . HOH D 3 .   ? 39.235 18.878 12.572  1.000 34.480 0  599  HOH A O   1 ? 
HETATM 3184 O O   . HOH D 3 .   ? -3.965 20.833 -11.378 1.000 44.710 0  600  HOH A O   1 ? 
HETATM 3185 O O   . HOH D 3 .   ? 24.121 41.865 17.971  1.000 50.670 0  601  HOH A O   1 ? 
HETATM 3186 O O   . HOH D 3 .   ? 10.375 39.758 7.818   1.000 29.430 0  602  HOH A O   1 ? 
HETATM 3187 O O   . HOH D 3 .   ? 19.917 13.217 -5.281  1.000 19.720 0  603  HOH A O   1 ? 
HETATM 3188 O O   . HOH D 3 .   ? 17.464 28.938 1.117   1.000 23.150 0  604  HOH A O   1 ? 
HETATM 3189 O O   . HOH D 3 .   ? 12.513 22.871 -8.255  1.000 32.720 0  605  HOH A O   1 ? 
HETATM 3190 O O   . HOH D 3 .   ? 27.517 20.851 24.493  1.000 35.350 0  606  HOH A O   1 ? 
HETATM 3191 O O   . HOH D 3 .   ? 27.119 46.110 2.928   1.000 57.280 0  607  HOH A O   1 ? 
HETATM 3192 O O   . HOH D 3 .   ? 24.037 27.853 27.477  1.000 36.240 0  608  HOH A O   1 ? 
HETATM 3193 O O   . HOH D 3 .   ? 14.146 41.956 6.724   1.000 40.450 0  609  HOH A O   1 ? 
HETATM 3194 O O   . HOH D 3 .   ? 22.535 10.412 5.427   1.000 44.510 0  610  HOH A O   1 ? 
HETATM 3195 O O   . HOH D 3 .   ? 39.177 16.012 -6.545  1.000 48.550 0  611  HOH A O   1 ? 
HETATM 3196 O O   . HOH D 3 .   ? 27.666 14.865 11.820  1.000 40.340 0  612  HOH A O   1 ? 
HETATM 3197 O O   . HOH D 3 .   ? 11.806 -1.423 -11.969 1.000 41.310 0  613  HOH A O   1 ? 
HETATM 3198 O O   . HOH D 3 .   ? 21.563 41.385 -2.732  1.000 26.510 0  614  HOH A O   1 ? 
HETATM 3199 O O   . HOH D 3 .   ? -2.306 28.553 -1.069  1.000 43.880 0  615  HOH A O   1 ? 
HETATM 3200 O O   . HOH D 3 .   ? 9.610  27.212 -7.985  1.000 24.110 0  616  HOH A O   1 ? 
HETATM 3201 O O   . HOH D 3 .   ? 30.930 39.059 15.444  1.000 50.250 0  617  HOH A O   1 ? 
HETATM 3202 O O   . HOH D 3 .   ? 14.192 19.720 -11.589 1.000 33.710 0  618  HOH A O   1 ? 
HETATM 3203 O O   . HOH D 3 .   ? 10.570 13.388 13.819  1.000 39.850 0  619  HOH A O   1 ? 
HETATM 3204 O O   . HOH D 3 .   ? 16.766 16.539 -10.956 1.000 19.030 0  620  HOH A O   1 ? 
HETATM 3205 O O   . HOH D 3 .   ? -2.237 26.256 5.922   1.000 22.690 0  621  HOH A O   1 ? 
HETATM 3206 O O   . HOH D 3 .   ? 36.284 19.992 4.988   1.000 32.070 0  622  HOH A O   1 ? 
HETATM 3207 O O   . HOH D 3 .   ? 0.758  28.302 -11.910 1.000 57.040 0  623  HOH A O   1 ? 
HETATM 3208 O O   . HOH D 3 .   ? -2.258 8.091  -6.967  1.000 33.900 0  624  HOH A O   1 ? 
HETATM 3209 O O   . HOH D 3 .   ? 37.522 23.967 -9.010  1.000 41.390 0  625  HOH A O   1 ? 
HETATM 3210 O O   . HOH D 3 .   ? 22.533 30.287 -14.523 1.000 45.780 0  626  HOH A O   1 ? 
HETATM 3211 O O   . HOH D 3 .   ? 22.237 26.620 -10.989 1.000 30.490 0  627  HOH A O   1 ? 
HETATM 3212 O O   . HOH D 3 .   ? -1.291 8.237  4.421   1.000 40.200 0  628  HOH A O   1 ? 
HETATM 3213 O O   . HOH D 3 .   ? 16.495 22.279 9.421   1.000 22.370 0  629  HOH A O   1 ? 
HETATM 3214 O O   . HOH D 3 .   ? -1.123 17.621 8.328   1.000 41.450 0  630  HOH A O   1 ? 
HETATM 3215 O O   . HOH D 3 .   ? 19.343 25.134 -13.095 1.000 40.640 0  631  HOH A O   1 ? 
HETATM 3216 O O   . HOH D 3 .   ? -1.913 33.989 2.226   1.000 22.910 0  632  HOH A O   1 ? 
HETATM 3217 O O   . HOH D 3 .   ? -1.859 29.181 -7.676  1.000 48.720 0  633  HOH A O   1 ? 
HETATM 3218 O O   . HOH D 3 .   ? -1.093 30.147 4.509   1.000 44.690 0  634  HOH A O   1 ? 
HETATM 3219 O O   . HOH D 3 .   ? 19.028 15.229 -10.435 1.000 24.290 0  635  HOH A O   1 ? 
HETATM 3220 O O   . HOH D 3 .   ? 34.661 37.036 31.484  1.000 42.930 0  636  HOH A O   1 ? 
HETATM 3221 O O   . HOH D 3 .   ? -0.007 36.944 7.090   1.000 37.960 0  637  HOH A O   1 ? 
HETATM 3222 O O   . HOH D 3 .   ? 1.698  5.865  -1.726  1.000 36.860 0  638  HOH A O   1 ? 
HETATM 3223 O O   . HOH D 3 .   ? 22.545 30.051 25.730  1.000 34.950 0  639  HOH A O   1 ? 
HETATM 3224 O O   . HOH D 3 .   ? 37.479 36.492 11.729  1.000 30.000 0  640  HOH A O   1 ? 
HETATM 3225 O O   . HOH D 3 .   ? -2.594 12.624 -1.231  1.000 48.000 0  641  HOH A O   1 ? 
HETATM 3226 O O   . HOH D 3 .   ? 34.573 38.470 18.357  1.000 25.780 0  642  HOH A O   1 ? 
HETATM 3227 O O   . HOH D 3 .   ? 20.422 40.991 -5.152  1.000 20.280 0  643  HOH A O   1 ? 
HETATM 3228 O O   . HOH D 3 .   ? 3.417  30.744 -7.460  1.000 31.740 0  644  HOH A O   1 ? 
HETATM 3229 O O   . HOH D 3 .   ? 13.442 0.000  0.000   0.500 22.960 0  645  HOH A O   1 ? 
HETATM 3230 O O   . HOH D 3 .   ? 35.921 16.386 21.029  1.000 51.420 0  646  HOH A O   1 ? 
HETATM 3231 O O   . HOH D 3 .   ? 14.623 36.458 23.708  1.000 24.460 0  647  HOH A O   1 ? 
HETATM 3232 O O   . HOH D 3 .   ? 24.084 21.746 27.961  1.000 42.100 0  648  HOH A O   1 ? 
HETATM 3233 O O   . HOH D 3 .   ? 19.949 20.521 3.845   1.000 32.710 0  649  HOH A O   1 ? 
HETATM 3234 O O   . HOH D 3 .   ? 3.731  29.932 18.754  1.000 42.510 0  650  HOH A O   1 ? 
HETATM 3235 O O   . HOH D 3 .   ? 15.009 19.846 6.905   1.000 30.000 0  651  HOH A O   1 ? 
HETATM 3236 O O   . HOH D 3 .   ? 28.547 38.689 14.962  1.000 40.960 0  652  HOH A O   1 ? 
HETATM 3237 O O   . HOH D 3 .   ? 21.911 39.674 19.475  1.000 27.660 0  653  HOH A O   1 ? 
HETATM 3238 O O   . HOH D 3 .   ? 2.824  6.061  -11.750 1.000 30.050 0  654  HOH A O   1 ? 
HETATM 3239 O O   . HOH D 3 .   ? 0.798  6.934  -9.557  1.000 53.510 0  655  HOH A O   1 ? 
HETATM 3240 O O   . HOH D 3 .   ? 39.214 13.782 -6.158  1.000 57.520 0  656  HOH A O   1 ? 
HETATM 3241 O O   . HOH D 3 .   ? -1.789 18.326 -5.462  1.000 28.820 0  657  HOH A O   1 ? 
HETATM 3242 O O   . HOH D 3 .   ? 2.190  3.133  -3.948  1.000 55.250 0  658  HOH A O   1 ? 
HETATM 3243 O O   . HOH D 3 .   ? -0.701 21.871 -11.686 1.000 35.530 0  659  HOH A O   1 ? 
HETATM 3244 O O   . HOH D 3 .   ? 35.947 25.802 -8.396  1.000 34.450 0  660  HOH A O   1 ? 
HETATM 3245 O O   . HOH D 3 .   ? 18.338 27.551 3.366   1.000 29.540 0  661  HOH A O   1 ? 
HETATM 3246 O O   . HOH D 3 .   ? 17.908 19.848 14.068  1.000 35.330 0  662  HOH A O   1 ? 
HETATM 3247 O O   . HOH D 3 .   ? 20.798 22.563 -1.169  1.000 31.360 0  663  HOH A O   1 ? 
HETATM 3248 O O   . HOH D 3 .   ? 46.647 25.555 9.920   1.000 53.400 0  664  HOH A O   1 ? 
HETATM 3249 O O   . HOH D 3 .   ? 27.388 44.899 5.080   1.000 32.280 0  665  HOH A O   1 ? 
HETATM 3250 O O   . HOH D 3 .   ? 22.369 29.139 29.642  1.000 44.640 0  666  HOH A O   1 ? 
HETATM 3251 O O   . HOH D 3 .   ? -2.704 13.856 -3.248  1.000 42.440 0  667  HOH A O   1 ? 
HETATM 3252 O O   . HOH D 3 .   ? 20.479 25.769 2.891   1.000 25.960 0  668  HOH A O   1 ? 
HETATM 3253 O O   . HOH D 3 .   ? 39.770 32.860 -2.642  1.000 57.130 0  669  HOH A O   1 ? 
HETATM 3254 O O   . HOH D 3 .   ? 13.374 26.525 -9.911  1.000 26.600 0  670  HOH A O   1 ? 
HETATM 3255 O O   . HOH D 3 .   ? -3.913 20.089 6.020   1.000 42.760 0  671  HOH A O   1 ? 
HETATM 3256 O O   . HOH D 3 .   ? 17.600 21.777 3.512   1.000 28.260 0  672  HOH A O   1 ? 
HETATM 3257 O O   . HOH D 3 .   ? 43.286 33.272 9.291   1.000 62.970 0  673  HOH A O   1 ? 
HETATM 3258 O O   . HOH D 3 .   ? 37.677 13.851 -9.048  1.000 37.170 0  674  HOH A O   1 ? 
HETATM 3259 O O   . HOH D 3 .   ? 40.228 40.796 24.477  1.000 36.960 0  675  HOH A O   1 ? 
HETATM 3260 O O   . HOH D 3 .   ? -3.514 25.112 18.494  1.000 34.510 0  676  HOH A O   1 ? 
HETATM 3261 O O   . HOH D 3 .   ? -5.541 23.215 4.485   1.000 52.150 0  677  HOH A O   1 ? 
HETATM 3262 O O   . HOH D 3 .   ? 16.297 11.843 9.259   1.000 40.170 0  678  HOH A O   1 ? 
HETATM 3263 O O   . HOH D 3 .   ? 12.884 20.143 -6.764  1.000 20.190 0  679  HOH A O   1 ? 
HETATM 3264 O O   . HOH D 3 .   ? 32.603 14.715 13.476  1.000 49.140 0  680  HOH A O   1 ? 
HETATM 3265 O O   . HOH D 3 .   ? 3.386  -1.098 1.195   1.000 46.940 0  681  HOH A O   1 ? 
HETATM 3266 O O   . HOH D 3 .   ? 20.821 -7.031 -10.239 1.000 50.590 0  682  HOH A O   1 ? 
HETATM 3267 O O   . HOH D 3 .   ? 39.485 12.014 -15.196 1.000 57.440 0  683  HOH A O   1 ? 
HETATM 3268 O O   . HOH D 3 .   ? 19.490 18.967 5.993   1.000 50.380 0  684  HOH A O   1 ? 
HETATM 3269 O O   . HOH D 3 .   ? 19.160 17.424 -18.599 1.000 39.350 0  685  HOH A O   1 ? 
HETATM 3270 O O   . HOH D 3 .   ? 37.198 20.464 -13.712 1.000 53.240 0  686  HOH A O   1 ? 
HETATM 3271 O O   . HOH D 3 .   ? 24.096 18.747 20.144  1.000 45.900 0  687  HOH A O   1 ? 
HETATM 3272 O O   . HOH D 3 .   ? 23.573 24.560 -15.431 1.000 47.670 0  688  HOH A O   1 ? 
HETATM 3273 O O   . HOH D 3 .   ? 17.084 20.919 -2.758  1.000 38.100 0  689  HOH A O   1 ? 
HETATM 3274 O O   . HOH D 3 .   ? 17.438 15.227 4.744   1.000 40.640 0  690  HOH A O   1 ? 
HETATM 3275 O O   . HOH D 3 .   ? 35.006 37.800 12.124  1.000 43.710 0  691  HOH A O   1 ? 
HETATM 3276 O O   . HOH D 3 .   ? -0.174 28.911 -9.651  1.000 37.240 0  692  HOH A O   1 ? 
HETATM 3277 O O   . HOH D 3 .   ? -2.817 15.987 -4.341  1.000 30.810 0  693  HOH A O   1 ? 
HETATM 3278 O O   . HOH D 3 .   ? 22.609 26.486 -1.958  1.000 39.140 0  694  HOH A O   1 ? 
HETATM 3279 O O   . HOH D 3 .   ? 47.042 32.815 24.682  1.000 52.450 0  695  HOH A O   1 ? 
HETATM 3280 O O   . HOH D 3 .   ? 23.563 -3.391 -0.682  1.000 59.640 0  696  HOH A O   1 ? 
HETATM 3281 O O   . HOH D 3 .   ? 7.101  28.072 -8.517  1.000 51.780 0  697  HOH A O   1 ? 
HETATM 3282 O O   . HOH D 3 .   ? 24.346 28.651 -9.713  1.000 39.540 0  698  HOH A O   1 ? 
HETATM 3283 O O   . HOH D 3 .   ? -3.299 29.588 17.189  1.000 48.400 0  699  HOH A O   1 ? 
HETATM 3284 O O   . HOH D 3 .   ? -4.245 22.056 -2.342  1.000 50.090 0  700  HOH A O   1 ? 
HETATM 3285 O O   . HOH D 3 .   ? 44.291 35.267 10.029  1.000 54.080 0  701  HOH A O   1 ? 
HETATM 3286 O O   . HOH D 3 .   ? 20.314 41.876 19.102  1.000 50.410 0  702  HOH A O   1 ? 
HETATM 3287 O O   . HOH D 3 .   ? 28.490 39.257 19.021  1.000 56.880 0  703  HOH A O   1 ? 
HETATM 3288 O O   . HOH D 3 .   ? 17.445 15.197 -18.960 1.000 50.680 0  704  HOH A O   1 ? 
HETATM 3289 O O   . HOH D 3 .   ? 29.421 9.924  2.647   1.000 49.290 0  705  HOH A O   1 ? 
HETATM 3290 O O   . HOH D 3 .   ? 3.647  12.108 6.244   1.000 34.660 0  706  HOH A O   1 ? 
HETATM 3291 O O   . HOH D 3 .   ? 26.605 16.217 9.753   1.000 42.820 0  707  HOH A O   1 ? 
HETATM 3292 O O   . HOH D 3 .   ? 27.476 25.113 -19.374 1.000 42.730 0  708  HOH A O   1 ? 
HETATM 3293 O O   . HOH D 3 .   ? 21.843 17.521 13.528  1.000 56.490 0  709  HOH A O   1 ? 
HETATM 3294 O O   . HOH D 3 .   ? 32.372 38.410 3.846   1.000 36.890 0  710  HOH A O   1 ? 
HETATM 3295 O O   . HOH D 3 .   ? 37.749 10.469 -12.011 1.000 60.190 0  711  HOH A O   1 ? 
HETATM 3296 O O   . HOH D 3 .   ? -2.074 26.586 -10.009 1.000 49.330 0  712  HOH A O   1 ? 
HETATM 3297 O O   . HOH D 3 .   ? 6.717  21.248 -12.410 1.000 54.050 0  713  HOH A O   1 ? 
HETATM 3298 O O   . HOH D 3 .   ? 7.502  39.606 5.677   1.000 42.780 0  714  HOH A O   1 ? 
HETATM 3299 O O   . HOH D 3 .   ? 27.712 11.368 -21.432 1.000 45.100 0  715  HOH A O   1 ? 
HETATM 3300 O O   . HOH D 3 .   ? 8.115  38.106 3.275   1.000 23.650 0  716  HOH A O   1 ? 
HETATM 3301 O O   . HOH D 3 .   ? 36.710 14.908 14.055  1.000 61.590 0  717  HOH A O   1 ? 
HETATM 3302 O O   . HOH D 3 .   ? 48.303 32.507 27.067  1.000 57.230 0  718  HOH A O   1 ? 
HETATM 3303 O O   . HOH D 3 .   ? 20.492 35.114 -8.476  1.000 41.650 0  719  HOH A O   1 ? 
HETATM 3304 O O   . HOH D 3 .   ? -3.558 22.391 5.564   1.000 40.020 0  720  HOH A O   1 ? 
HETATM 3305 O O   . HOH D 3 .   ? 12.143 33.764 21.431  1.000 45.410 0  721  HOH A O   1 ? 
HETATM 3306 O O   . HOH D 3 .   ? 28.334 14.820 -2.057  1.000 64.040 0  722  HOH A O   1 ? 
HETATM 3307 O O   . HOH D 3 .   ? -7.104 24.623 -0.883  1.000 49.880 0  723  HOH A O   1 ? 
HETATM 3308 O O   . HOH D 3 .   ? 8.632  0.000  0.000   0.500 55.400 0  724  HOH A O   1 ? 
HETATM 3309 O O   . HOH D 3 .   ? 30.079 40.388 10.783  1.000 34.250 0  725  HOH A O   1 ? 
HETATM 3310 O O   . HOH D 3 .   ? 42.289 23.158 0.888   1.000 52.690 0  726  HOH A O   1 ? 
HETATM 3311 O O   . HOH D 3 .   ? 10.151 41.473 1.660   1.000 38.720 0  727  HOH A O   1 ? 
HETATM 3312 O O   . HOH D 3 .   ? 6.417  31.082 21.428  1.000 46.970 0  728  HOH A O   1 ? 
HETATM 3313 O O   . HOH D 3 .   ? 17.992 20.372 10.113  1.000 45.930 0  729  HOH A O   1 ? 
HETATM 3314 O O   . HOH D 3 .   ? 57.624 34.325 10.974  1.000 59.380 0  730  HOH A O   1 ? 
HETATM 3315 O O   . HOH D 3 .   ? 52.608 29.511 4.217   1.000 45.380 0  731  HOH A O   1 ? 
HETATM 3316 O O   . HOH D 3 .   ? 15.723 20.358 -7.151  1.000 61.810 0  732  HOH A O   1 ? 
HETATM 3317 O O   . HOH D 3 .   ? 17.773 13.584 6.250   1.000 43.700 0  733  HOH A O   1 ? 
HETATM 3318 O O   . HOH D 3 .   ? 5.722  18.911 34.256  1.000 52.250 0  734  HOH A O   1 ? 
HETATM 3319 O O   . HOH D 3 .   ? 25.891 4.867  0.849   1.000 45.040 0  735  HOH A O   1 ? 
HETATM 3320 O O   . HOH D 3 .   ? 4.300  20.305 30.006  1.000 46.470 0  736  HOH A O   1 ? 
HETATM 3321 O O   . HOH D 3 .   ? 27.481 15.804 14.295  1.000 54.370 0  737  HOH A O   1 ? 
HETATM 3322 O O   . HOH D 3 .   ? 30.154 33.017 24.462  1.000 47.820 0  738  HOH A O   1 ? 
HETATM 3323 O O   . HOH D 3 .   ? 16.240 38.273 25.080  1.000 43.940 0  739  HOH A O   1 ? 
HETATM 3324 O O   . HOH D 3 .   ? 24.929 14.568 8.862   1.000 51.620 0  740  HOH A O   1 ? 
HETATM 3325 O O   . HOH D 3 .   ? 25.569 17.929 21.929  1.000 46.120 0  741  HOH A O   1 ? 
HETATM 3326 O O   . HOH D 3 .   ? 16.062 35.434 28.636  1.000 49.510 0  742  HOH A O   1 ? 
HETATM 3327 O O   . HOH D 3 .   ? 14.164 12.510 11.348  1.000 51.680 0  743  HOH A O   1 ? 
HETATM 3328 O O   . HOH D 3 .   ? 14.392 22.543 -10.175 1.000 41.960 0  744  HOH A O   1 ? 
HETATM 3329 O O   . HOH D 3 .   ? 23.765 19.145 23.759  1.000 48.810 0  745  HOH A O   1 ? 
HETATM 3330 O O   . HOH D 3 .   ? 9.032  38.866 -1.246  1.000 32.720 0  746  HOH A O   1 ? 
HETATM 3331 O O   . HOH D 3 .   ? 3.095  39.192 3.789   1.000 35.870 0  747  HOH A O   1 ? 
HETATM 3332 O O   . HOH D 3 .   ? -1.600 32.755 7.011   1.000 41.120 0  748  HOH A O   1 ? 
HETATM 3333 O O   . HOH D 3 .   ? 46.368 24.328 21.049  1.000 49.090 0  749  HOH A O   1 ? 
HETATM 3334 O O   . HOH D 3 .   ? 21.653 -3.662 -9.844  1.000 51.540 0  750  HOH A O   1 ? 
HETATM 3335 O O   . HOH D 3 .   ? 14.755 25.268 -11.794 1.000 35.610 0  751  HOH A O   1 ? 
HETATM 3336 O O   . HOH D 3 .   ? 2.199  9.978  6.814   1.000 49.870 0  752  HOH A O   1 ? 
HETATM 3337 O O   . HOH D 3 .   ? 19.284 28.376 -4.798  1.000 52.410 0  753  HOH A O   1 ? 
HETATM 3338 O O   . HOH D 3 .   ? 35.789 39.865 14.202  1.000 47.940 0  754  HOH A O   1 ? 
HETATM 3339 O O   . HOH D 3 .   ? -5.633 27.854 8.079   1.000 48.030 0  755  HOH A O   1 ? 
HETATM 3340 O O   . HOH D 3 .   ? 2.788  13.799 8.239   1.000 41.340 0  756  HOH A O   1 ? 
HETATM 3341 O O   . HOH D 3 .   ? 33.020 40.115 11.945  1.000 44.790 0  757  HOH A O   1 ? 
HETATM 3342 O O   . HOH D 3 .   ? 25.841 25.083 -21.660 1.000 36.190 0  758  HOH A O   1 ? 
HETATM 3343 O O   . HOH D 3 .   ? 18.970 21.167 -4.658  1.000 30.900 0  759  HOH A O   1 ? 
HETATM 3344 O O   . HOH D 3 .   ? 19.281 31.319 -3.613  1.000 27.660 0  760  HOH A O   1 ? 
HETATM 3345 O O   . HOH D 3 .   ? 9.596  31.369 29.202  1.000 53.070 0  761  HOH A O   1 ? 
HETATM 3346 O O   . HOH D 3 .   ? 5.843  40.196 0.999   1.000 42.820 0  762  HOH A O   1 ? 
HETATM 3347 O O   . HOH D 3 .   ? 9.812  32.097 25.835  1.000 39.500 0  763  HOH A O   1 ? 
HETATM 3348 O O   . HOH D 3 .   ? 1.917  16.370 11.576  1.000 38.280 0  764  HOH A O   1 ? 
HETATM 3349 O O   . HOH D 3 .   ? 43.348 16.214 -9.634  1.000 54.530 0  765  HOH A O   1 ? 
HETATM 3350 O O   . HOH D 3 .   ? 0.526  28.330 -14.833 1.000 51.860 0  766  HOH A O   1 ? 
HETATM 3351 O O   . HOH D 3 .   ? 0.783  15.172 9.561   1.000 40.700 0  767  HOH A O   1 ? 
HETATM 3352 O O   . HOH D 3 .   ? 32.990 43.959 9.304   1.000 50.760 0  768  HOH A O   1 ? 
HETATM 3353 O O   . HOH D 3 .   ? 46.090 20.719 -5.229  1.000 51.360 0  769  HOH A O   1 ? 
HETATM 3354 O O   . HOH D 3 .   ? 34.661 43.054 8.057   1.000 53.270 0  770  HOH A O   1 ? 
HETATM 3355 O O   . HOH D 3 .   ? 48.639 24.735 -9.837  1.000 53.800 0  771  HOH A O   1 ? 
HETATM 3356 O O   . HOH E 3 .   ? 19.748 -1.208 -12.838 1.000 35.570 0  1001 HOH D O   1 ? 
HETATM 3357 O O   . HOH E 3 .   ? 12.437 0.163  -14.126 1.000 36.850 0  1002 HOH D O   1 ? 
HETATM 3358 O O   . HOH E 3 .   ? 4.830  9.894  -16.617 1.000 45.280 0  1003 HOH D O   1 ? 
HETATM 3359 O O   . HOH E 3 .   ? 1.785  6.962  -13.885 1.000 50.450 0  1004 HOH D O   1 ? 
HETATM 3360 O O   . HOH E 3 .   ? 11.869 5.795  -18.018 1.000 36.500 0  1005 HOH D O   1 ? 
HETATM 3361 O O   . HOH E 3 .   ? 18.904 -0.007 -17.702 1.000 48.770 0  1006 HOH D O   1 ? 
HETATM 3362 O O   . HOH F 3 .   ? 7.231  30.691 19.110  1.000 31.540 0  1001 HOH E O   1 ? 
HETATM 3363 O O   . HOH F 3 .   ? 9.810  35.188 19.592  1.000 58.670 0  1002 HOH E O   1 ? 
HETATM 3364 O O   . HOH F 3 .   ? 8.179  41.130 17.147  1.000 61.700 0  1003 HOH E O   1 ? 
HETATM 3365 O O   . HOH F 3 .   ? 15.654 40.117 17.265  1.000 37.700 0  1004 HOH E O   1 ? 
HETATM 3366 O O   . HOH F 3 .   ? -2.636 33.585 11.455  1.000 48.650 0  1005 HOH E O   1 ? 
HETATM 3367 O O   . HOH F 3 .   ? 16.032 42.224 15.623  1.000 50.720 0  1006 HOH E O   1 ? 
HETATM 3368 O O   . HOH F 3 .   ? 6.778  43.398 15.151  1.000 58.290 0  1007 HOH E O   1 ? 
# 
