data_9F8S
# 
_entry.id   9F8S 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9F8S         pdb_00009f8s 10.2210/pdb9f8s/pdb 
WWPDB D_1292138242 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-16 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9F8S 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-06 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB 'Contains the same protein complexed with different ligand' 9F8H unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8I unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8J unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8K unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8L unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8M unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8N unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8O unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8P unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8R unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8Q unspecified 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 wulf.blankenfeldt@helmholtz-hzi.de Wulf   Blankenfeldt ? 'principal investigator/group leader' 0000-0001-9886-9668 
4 c.kunick@tu-braunschweig.de        Conrad Kunick       ? 'principal investigator/group leader' 0000-0001-7041-5322 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zimmermann, M.'   1 0009-0005-8293-7255 
'Thiemann, M.'     2 0009-0009-1111-0671 
'Kunick, C.'       3 0000-0001-7041-5322 
'Blankenfeldt, W.' 4 0000-0001-9886-9668 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Med.Chem. 
_citation.journal_id_ASTM           JMCMAR 
_citation.journal_id_CSD            0151 
_citation.journal_id_ISSN           0022-2623 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            68 
_citation.language                  ? 
_citation.page_first                7390 
_citation.page_last                 7420 
_citation.title                     
;From Bones to Bugs: Structure-Based Development of Raloxifene-Derived Pathoblockers That Inhibit Pyocyanin Production in Pseudomonas aeruginosa.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.jmedchem.4c03065 
_citation.pdbx_database_id_PubMed   40156840 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Thiemann, M.'        1  0009-0009-1111-0671 
primary 'Zimmermann, M.'      2  0009-0005-8293-7255 
primary 'Diederich, C.'       3  ?                   
primary 'Zhan, H.'            4  0009-0002-7304-9174 
primary 'Lebedev, M.'         5  0000-0001-7461-0977 
primary 'Pletz, J.'           6  ?                   
primary 'Baumgarten, J.'      7  0009-0003-6748-6316 
primary 'Handke, M.'          8  0009-0007-7175-3615 
primary 'Musken, M.'          9  ?                   
primary 'Breinbauer, R.'      10 0000-0001-6009-7359 
primary 'Krasteva-Christ, G.' 11 0000-0002-0113-521X 
primary 'Zanin, E.'           12 ?                   
primary 'Empting, M.'         13 ?                   
primary 'Schiedel, M.'        14 0000-0001-7365-3617 
primary 'Kunick, C.'          15 ?                   
primary 'Blankenfeldt, W.'    16 0000-0001-9886-9668 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Phenazine biosynthesis protein A/B'                                   21531.025 2   ? ? ? ? 
2 non-polymer syn GLYCEROL                                                               92.094    3   ? ? ? ? 
3 non-polymer syn '(4-chlorophenyl)-(6-oxidanyl-2-phenyl-1-benzothiophen-3-yl)methanone' 364.845   2   ? ? ? ? 
4 water       nat water                                                                  18.015    257 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGLVPRGSHMSDVESLENTSENRAQVAARQHNRKIVEQYMHTRGEARLKRHLLFTEDGVGGLWTTDSGQ
PIAIRGREKLGEHAVWSLQCFPDWVWTDIQIFETQDPNWFWVECRGEGAIVFPGYPRGQYRNHFLHSFRFENGLIKEQRE
FMNPCEQFRSLGIEVPEVRRDGLPS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGLVPRGSHMSDVESLENTSENRAQVAARQHNRKIVEQYMHTRGEARLKRHLLFTEDGVGGLWTTDSGQ
PIAIRGREKLGEHAVWSLQCFPDWVWTDIQIFETQDPNWFWVECRGEGAIVFPGYPRGQYRNHFLHSFRFENGLIKEQRE
FMNPCEQFRSLGIEVPEVRRDGLPS
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 GLYCEROL                                                               GOL   
3 '(4-chlorophenyl)-(6-oxidanyl-2-phenyl-1-benzothiophen-3-yl)methanone' A1IAM 
4 water                                                                  HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  ARG n 
1 18  GLY n 
1 19  SER n 
1 20  HIS n 
1 21  MET n 
1 22  SER n 
1 23  ASP n 
1 24  VAL n 
1 25  GLU n 
1 26  SER n 
1 27  LEU n 
1 28  GLU n 
1 29  ASN n 
1 30  THR n 
1 31  SER n 
1 32  GLU n 
1 33  ASN n 
1 34  ARG n 
1 35  ALA n 
1 36  GLN n 
1 37  VAL n 
1 38  ALA n 
1 39  ALA n 
1 40  ARG n 
1 41  GLN n 
1 42  HIS n 
1 43  ASN n 
1 44  ARG n 
1 45  LYS n 
1 46  ILE n 
1 47  VAL n 
1 48  GLU n 
1 49  GLN n 
1 50  TYR n 
1 51  MET n 
1 52  HIS n 
1 53  THR n 
1 54  ARG n 
1 55  GLY n 
1 56  GLU n 
1 57  ALA n 
1 58  ARG n 
1 59  LEU n 
1 60  LYS n 
1 61  ARG n 
1 62  HIS n 
1 63  LEU n 
1 64  LEU n 
1 65  PHE n 
1 66  THR n 
1 67  GLU n 
1 68  ASP n 
1 69  GLY n 
1 70  VAL n 
1 71  GLY n 
1 72  GLY n 
1 73  LEU n 
1 74  TRP n 
1 75  THR n 
1 76  THR n 
1 77  ASP n 
1 78  SER n 
1 79  GLY n 
1 80  GLN n 
1 81  PRO n 
1 82  ILE n 
1 83  ALA n 
1 84  ILE n 
1 85  ARG n 
1 86  GLY n 
1 87  ARG n 
1 88  GLU n 
1 89  LYS n 
1 90  LEU n 
1 91  GLY n 
1 92  GLU n 
1 93  HIS n 
1 94  ALA n 
1 95  VAL n 
1 96  TRP n 
1 97  SER n 
1 98  LEU n 
1 99  GLN n 
1 100 CYS n 
1 101 PHE n 
1 102 PRO n 
1 103 ASP n 
1 104 TRP n 
1 105 VAL n 
1 106 TRP n 
1 107 THR n 
1 108 ASP n 
1 109 ILE n 
1 110 GLN n 
1 111 ILE n 
1 112 PHE n 
1 113 GLU n 
1 114 THR n 
1 115 GLN n 
1 116 ASP n 
1 117 PRO n 
1 118 ASN n 
1 119 TRP n 
1 120 PHE n 
1 121 TRP n 
1 122 VAL n 
1 123 GLU n 
1 124 CYS n 
1 125 ARG n 
1 126 GLY n 
1 127 GLU n 
1 128 GLY n 
1 129 ALA n 
1 130 ILE n 
1 131 VAL n 
1 132 PHE n 
1 133 PRO n 
1 134 GLY n 
1 135 TYR n 
1 136 PRO n 
1 137 ARG n 
1 138 GLY n 
1 139 GLN n 
1 140 TYR n 
1 141 ARG n 
1 142 ASN n 
1 143 HIS n 
1 144 PHE n 
1 145 LEU n 
1 146 HIS n 
1 147 SER n 
1 148 PHE n 
1 149 ARG n 
1 150 PHE n 
1 151 GLU n 
1 152 ASN n 
1 153 GLY n 
1 154 LEU n 
1 155 ILE n 
1 156 LYS n 
1 157 GLU n 
1 158 GLN n 
1 159 ARG n 
1 160 GLU n 
1 161 PHE n 
1 162 MET n 
1 163 ASN n 
1 164 PRO n 
1 165 CYS n 
1 166 GLU n 
1 167 GLN n 
1 168 PHE n 
1 169 ARG n 
1 170 SER n 
1 171 LEU n 
1 172 GLY n 
1 173 ILE n 
1 174 GLU n 
1 175 VAL n 
1 176 PRO n 
1 177 GLU n 
1 178 VAL n 
1 179 ARG n 
1 180 ARG n 
1 181 ASP n 
1 182 GLY n 
1 183 LEU n 
1 184 PRO n 
1 185 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   185 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 Bcep18194_B1568 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Burkholderia lata' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     482957 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pET15b 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1IAM non-polymer         . '(4-chlorophenyl)-(6-oxidanyl-2-phenyl-1-benzothiophen-3-yl)methanone' 
'(4-Chlorophenyl)[6-hydroxy-2-phenylbenzo[b]thiophen-3-yl]methanone' 'C21 H13 Cl O2 S' 364.845 
ALA   'L-peptide linking' y ALANINE                                                                ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE                                                               ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                             ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                        ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE                                                               ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE                                                              ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                        ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE                                                                ? 'C2 H5 N O2'      75.067  
GOL   non-polymer         . GLYCEROL                                                               'GLYCERIN; PROPANE-1,2,3-TRIOL' 
'C3 H8 O3'        92.094  
HIS   'L-peptide linking' y HISTIDINE                                                              ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER                                                                  ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                                             ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE                                                                ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE                                                                 ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE                                                             ? 'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE                                                          ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE                                                                ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE                                                                 ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE                                                              ? 'C4 H9 N O3'      119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                                             ? 'C11 H12 N2 O2'   204.225 
TYR   'L-peptide linking' y TYROSINE                                                               ? 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE                                                                 ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -19 ?   ?   ?   A . n 
A 1 2   GLY 2   -18 ?   ?   ?   A . n 
A 1 3   SER 3   -17 ?   ?   ?   A . n 
A 1 4   SER 4   -16 ?   ?   ?   A . n 
A 1 5   HIS 5   -15 ?   ?   ?   A . n 
A 1 6   HIS 6   -14 ?   ?   ?   A . n 
A 1 7   HIS 7   -13 ?   ?   ?   A . n 
A 1 8   HIS 8   -12 ?   ?   ?   A . n 
A 1 9   HIS 9   -11 ?   ?   ?   A . n 
A 1 10  HIS 10  -10 ?   ?   ?   A . n 
A 1 11  SER 11  -9  ?   ?   ?   A . n 
A 1 12  SER 12  -8  ?   ?   ?   A . n 
A 1 13  GLY 13  -7  ?   ?   ?   A . n 
A 1 14  LEU 14  -6  ?   ?   ?   A . n 
A 1 15  VAL 15  -5  ?   ?   ?   A . n 
A 1 16  PRO 16  -4  ?   ?   ?   A . n 
A 1 17  ARG 17  -3  ?   ?   ?   A . n 
A 1 18  GLY 18  -2  ?   ?   ?   A . n 
A 1 19  SER 19  -1  ?   ?   ?   A . n 
A 1 20  HIS 20  0   ?   ?   ?   A . n 
A 1 21  MET 21  1   ?   ?   ?   A . n 
A 1 22  SER 22  2   ?   ?   ?   A . n 
A 1 23  ASP 23  3   ?   ?   ?   A . n 
A 1 24  VAL 24  4   ?   ?   ?   A . n 
A 1 25  GLU 25  5   ?   ?   ?   A . n 
A 1 26  SER 26  6   ?   ?   ?   A . n 
A 1 27  LEU 27  7   ?   ?   ?   A . n 
A 1 28  GLU 28  8   ?   ?   ?   A . n 
A 1 29  ASN 29  9   ?   ?   ?   A . n 
A 1 30  THR 30  10  ?   ?   ?   A . n 
A 1 31  SER 31  11  ?   ?   ?   A . n 
A 1 32  GLU 32  12  12  GLU GLU A . n 
A 1 33  ASN 33  13  13  ASN ASN A . n 
A 1 34  ARG 34  14  14  ARG ARG A . n 
A 1 35  ALA 35  15  15  ALA ALA A . n 
A 1 36  GLN 36  16  16  GLN GLN A . n 
A 1 37  VAL 37  17  17  VAL VAL A . n 
A 1 38  ALA 38  18  18  ALA ALA A . n 
A 1 39  ALA 39  19  19  ALA ALA A . n 
A 1 40  ARG 40  20  20  ARG ARG A . n 
A 1 41  GLN 41  21  21  GLN GLN A . n 
A 1 42  HIS 42  22  22  HIS HIS A . n 
A 1 43  ASN 43  23  23  ASN ASN A . n 
A 1 44  ARG 44  24  24  ARG ARG A . n 
A 1 45  LYS 45  25  25  LYS LYS A . n 
A 1 46  ILE 46  26  26  ILE ILE A . n 
A 1 47  VAL 47  27  27  VAL VAL A . n 
A 1 48  GLU 48  28  28  GLU GLU A . n 
A 1 49  GLN 49  29  29  GLN GLN A . n 
A 1 50  TYR 50  30  30  TYR TYR A . n 
A 1 51  MET 51  31  31  MET MET A . n 
A 1 52  HIS 52  32  32  HIS HIS A . n 
A 1 53  THR 53  33  33  THR THR A . n 
A 1 54  ARG 54  34  34  ARG ARG A . n 
A 1 55  GLY 55  35  35  GLY GLY A . n 
A 1 56  GLU 56  36  36  GLU GLU A . n 
A 1 57  ALA 57  37  37  ALA ALA A . n 
A 1 58  ARG 58  38  38  ARG ARG A . n 
A 1 59  LEU 59  39  39  LEU LEU A . n 
A 1 60  LYS 60  40  40  LYS LYS A . n 
A 1 61  ARG 61  41  41  ARG ARG A . n 
A 1 62  HIS 62  42  42  HIS HIS A . n 
A 1 63  LEU 63  43  43  LEU LEU A . n 
A 1 64  LEU 64  44  44  LEU LEU A . n 
A 1 65  PHE 65  45  45  PHE PHE A . n 
A 1 66  THR 66  46  46  THR THR A . n 
A 1 67  GLU 67  47  47  GLU GLU A . n 
A 1 68  ASP 68  48  48  ASP ASP A . n 
A 1 69  GLY 69  49  49  GLY GLY A . n 
A 1 70  VAL 70  50  50  VAL VAL A . n 
A 1 71  GLY 71  51  51  GLY GLY A . n 
A 1 72  GLY 72  52  52  GLY GLY A . n 
A 1 73  LEU 73  53  53  LEU LEU A . n 
A 1 74  TRP 74  54  54  TRP TRP A . n 
A 1 75  THR 75  55  55  THR THR A . n 
A 1 76  THR 76  56  56  THR THR A . n 
A 1 77  ASP 77  57  57  ASP ASP A . n 
A 1 78  SER 78  58  58  SER SER A . n 
A 1 79  GLY 79  59  59  GLY GLY A . n 
A 1 80  GLN 80  60  60  GLN GLN A . n 
A 1 81  PRO 81  61  61  PRO PRO A . n 
A 1 82  ILE 82  62  62  ILE ILE A . n 
A 1 83  ALA 83  63  63  ALA ALA A . n 
A 1 84  ILE 84  64  64  ILE ILE A . n 
A 1 85  ARG 85  65  65  ARG ARG A . n 
A 1 86  GLY 86  66  66  GLY GLY A . n 
A 1 87  ARG 87  67  67  ARG ARG A . n 
A 1 88  GLU 88  68  68  GLU GLU A . n 
A 1 89  LYS 89  69  69  LYS LYS A . n 
A 1 90  LEU 90  70  70  LEU LEU A . n 
A 1 91  GLY 91  71  71  GLY GLY A . n 
A 1 92  GLU 92  72  72  GLU GLU A . n 
A 1 93  HIS 93  73  73  HIS HIS A . n 
A 1 94  ALA 94  74  74  ALA ALA A . n 
A 1 95  VAL 95  75  75  VAL VAL A . n 
A 1 96  TRP 96  76  76  TRP TRP A . n 
A 1 97  SER 97  77  77  SER SER A . n 
A 1 98  LEU 98  78  78  LEU LEU A . n 
A 1 99  GLN 99  79  79  GLN GLN A . n 
A 1 100 CYS 100 80  80  CYS CYS A . n 
A 1 101 PHE 101 81  81  PHE PHE A . n 
A 1 102 PRO 102 82  82  PRO PRO A . n 
A 1 103 ASP 103 83  83  ASP ASP A . n 
A 1 104 TRP 104 84  84  TRP TRP A . n 
A 1 105 VAL 105 85  85  VAL VAL A . n 
A 1 106 TRP 106 86  86  TRP TRP A . n 
A 1 107 THR 107 87  87  THR THR A . n 
A 1 108 ASP 108 88  88  ASP ASP A . n 
A 1 109 ILE 109 89  89  ILE ILE A . n 
A 1 110 GLN 110 90  90  GLN GLN A . n 
A 1 111 ILE 111 91  91  ILE ILE A . n 
A 1 112 PHE 112 92  92  PHE PHE A . n 
A 1 113 GLU 113 93  93  GLU GLU A . n 
A 1 114 THR 114 94  94  THR THR A . n 
A 1 115 GLN 115 95  95  GLN GLN A . n 
A 1 116 ASP 116 96  96  ASP ASP A . n 
A 1 117 PRO 117 97  97  PRO PRO A . n 
A 1 118 ASN 118 98  98  ASN ASN A . n 
A 1 119 TRP 119 99  99  TRP TRP A . n 
A 1 120 PHE 120 100 100 PHE PHE A . n 
A 1 121 TRP 121 101 101 TRP TRP A . n 
A 1 122 VAL 122 102 102 VAL VAL A . n 
A 1 123 GLU 123 103 103 GLU GLU A . n 
A 1 124 CYS 124 104 104 CYS CYS A . n 
A 1 125 ARG 125 105 105 ARG ARG A . n 
A 1 126 GLY 126 106 106 GLY GLY A . n 
A 1 127 GLU 127 107 107 GLU GLU A . n 
A 1 128 GLY 128 108 108 GLY GLY A . n 
A 1 129 ALA 129 109 109 ALA ALA A . n 
A 1 130 ILE 130 110 110 ILE ILE A . n 
A 1 131 VAL 131 111 111 VAL VAL A . n 
A 1 132 PHE 132 112 112 PHE PHE A . n 
A 1 133 PRO 133 113 113 PRO PRO A . n 
A 1 134 GLY 134 114 114 GLY GLY A . n 
A 1 135 TYR 135 115 115 TYR TYR A . n 
A 1 136 PRO 136 116 116 PRO PRO A . n 
A 1 137 ARG 137 117 117 ARG ARG A . n 
A 1 138 GLY 138 118 118 GLY GLY A . n 
A 1 139 GLN 139 119 119 GLN GLN A . n 
A 1 140 TYR 140 120 120 TYR TYR A . n 
A 1 141 ARG 141 121 121 ARG ARG A . n 
A 1 142 ASN 142 122 122 ASN ASN A . n 
A 1 143 HIS 143 123 123 HIS HIS A . n 
A 1 144 PHE 144 124 124 PHE PHE A . n 
A 1 145 LEU 145 125 125 LEU LEU A . n 
A 1 146 HIS 146 126 126 HIS HIS A . n 
A 1 147 SER 147 127 127 SER SER A . n 
A 1 148 PHE 148 128 128 PHE PHE A . n 
A 1 149 ARG 149 129 129 ARG ARG A . n 
A 1 150 PHE 150 130 130 PHE PHE A . n 
A 1 151 GLU 151 131 131 GLU GLU A . n 
A 1 152 ASN 152 132 132 ASN ASN A . n 
A 1 153 GLY 153 133 133 GLY GLY A . n 
A 1 154 LEU 154 134 134 LEU LEU A . n 
A 1 155 ILE 155 135 135 ILE ILE A . n 
A 1 156 LYS 156 136 136 LYS LYS A . n 
A 1 157 GLU 157 137 137 GLU GLU A . n 
A 1 158 GLN 158 138 138 GLN GLN A . n 
A 1 159 ARG 159 139 139 ARG ARG A . n 
A 1 160 GLU 160 140 140 GLU GLU A . n 
A 1 161 PHE 161 141 141 PHE PHE A . n 
A 1 162 MET 162 142 142 MET MET A . n 
A 1 163 ASN 163 143 143 ASN ASN A . n 
A 1 164 PRO 164 144 144 PRO PRO A . n 
A 1 165 CYS 165 145 145 CYS CYS A . n 
A 1 166 GLU 166 146 146 GLU GLU A . n 
A 1 167 GLN 167 147 147 GLN GLN A . n 
A 1 168 PHE 168 148 148 PHE PHE A . n 
A 1 169 ARG 169 149 149 ARG ARG A . n 
A 1 170 SER 170 150 150 SER SER A . n 
A 1 171 LEU 171 151 151 LEU LEU A . n 
A 1 172 GLY 172 152 152 GLY GLY A . n 
A 1 173 ILE 173 153 153 ILE ILE A . n 
A 1 174 GLU 174 154 154 GLU GLU A . n 
A 1 175 VAL 175 155 155 VAL VAL A . n 
A 1 176 PRO 176 156 156 PRO PRO A . n 
A 1 177 GLU 177 157 157 GLU GLU A . n 
A 1 178 VAL 178 158 158 VAL VAL A . n 
A 1 179 ARG 179 159 159 ARG ARG A . n 
A 1 180 ARG 180 160 160 ARG ARG A . n 
A 1 181 ASP 181 161 161 ASP ASP A . n 
A 1 182 GLY 182 162 162 GLY GLY A . n 
A 1 183 LEU 183 163 163 LEU LEU A . n 
A 1 184 PRO 184 164 164 PRO PRO A . n 
A 1 185 SER 185 165 165 SER SER A . n 
B 1 1   MET 1   -19 ?   ?   ?   B . n 
B 1 2   GLY 2   -18 ?   ?   ?   B . n 
B 1 3   SER 3   -17 ?   ?   ?   B . n 
B 1 4   SER 4   -16 ?   ?   ?   B . n 
B 1 5   HIS 5   -15 ?   ?   ?   B . n 
B 1 6   HIS 6   -14 ?   ?   ?   B . n 
B 1 7   HIS 7   -13 ?   ?   ?   B . n 
B 1 8   HIS 8   -12 ?   ?   ?   B . n 
B 1 9   HIS 9   -11 ?   ?   ?   B . n 
B 1 10  HIS 10  -10 ?   ?   ?   B . n 
B 1 11  SER 11  -9  ?   ?   ?   B . n 
B 1 12  SER 12  -8  ?   ?   ?   B . n 
B 1 13  GLY 13  -7  ?   ?   ?   B . n 
B 1 14  LEU 14  -6  ?   ?   ?   B . n 
B 1 15  VAL 15  -5  ?   ?   ?   B . n 
B 1 16  PRO 16  -4  ?   ?   ?   B . n 
B 1 17  ARG 17  -3  ?   ?   ?   B . n 
B 1 18  GLY 18  -2  ?   ?   ?   B . n 
B 1 19  SER 19  -1  ?   ?   ?   B . n 
B 1 20  HIS 20  0   ?   ?   ?   B . n 
B 1 21  MET 21  1   ?   ?   ?   B . n 
B 1 22  SER 22  2   ?   ?   ?   B . n 
B 1 23  ASP 23  3   ?   ?   ?   B . n 
B 1 24  VAL 24  4   ?   ?   ?   B . n 
B 1 25  GLU 25  5   ?   ?   ?   B . n 
B 1 26  SER 26  6   ?   ?   ?   B . n 
B 1 27  LEU 27  7   ?   ?   ?   B . n 
B 1 28  GLU 28  8   ?   ?   ?   B . n 
B 1 29  ASN 29  9   ?   ?   ?   B . n 
B 1 30  THR 30  10  ?   ?   ?   B . n 
B 1 31  SER 31  11  ?   ?   ?   B . n 
B 1 32  GLU 32  12  12  GLU GLU B . n 
B 1 33  ASN 33  13  13  ASN ASN B . n 
B 1 34  ARG 34  14  14  ARG ARG B . n 
B 1 35  ALA 35  15  15  ALA ALA B . n 
B 1 36  GLN 36  16  16  GLN GLN B . n 
B 1 37  VAL 37  17  17  VAL VAL B . n 
B 1 38  ALA 38  18  18  ALA ALA B . n 
B 1 39  ALA 39  19  19  ALA ALA B . n 
B 1 40  ARG 40  20  20  ARG ARG B . n 
B 1 41  GLN 41  21  21  GLN GLN B . n 
B 1 42  HIS 42  22  22  HIS HIS B . n 
B 1 43  ASN 43  23  23  ASN ASN B . n 
B 1 44  ARG 44  24  24  ARG ARG B . n 
B 1 45  LYS 45  25  25  LYS LYS B . n 
B 1 46  ILE 46  26  26  ILE ILE B . n 
B 1 47  VAL 47  27  27  VAL VAL B . n 
B 1 48  GLU 48  28  28  GLU GLU B . n 
B 1 49  GLN 49  29  29  GLN GLN B . n 
B 1 50  TYR 50  30  30  TYR TYR B . n 
B 1 51  MET 51  31  31  MET MET B . n 
B 1 52  HIS 52  32  32  HIS HIS B . n 
B 1 53  THR 53  33  33  THR THR B . n 
B 1 54  ARG 54  34  34  ARG ARG B . n 
B 1 55  GLY 55  35  35  GLY GLY B . n 
B 1 56  GLU 56  36  36  GLU GLU B . n 
B 1 57  ALA 57  37  37  ALA ALA B . n 
B 1 58  ARG 58  38  38  ARG ARG B . n 
B 1 59  LEU 59  39  39  LEU LEU B . n 
B 1 60  LYS 60  40  40  LYS LYS B . n 
B 1 61  ARG 61  41  41  ARG ARG B . n 
B 1 62  HIS 62  42  42  HIS HIS B . n 
B 1 63  LEU 63  43  43  LEU LEU B . n 
B 1 64  LEU 64  44  44  LEU LEU B . n 
B 1 65  PHE 65  45  45  PHE PHE B . n 
B 1 66  THR 66  46  46  THR THR B . n 
B 1 67  GLU 67  47  47  GLU GLU B . n 
B 1 68  ASP 68  48  48  ASP ASP B . n 
B 1 69  GLY 69  49  49  GLY GLY B . n 
B 1 70  VAL 70  50  50  VAL VAL B . n 
B 1 71  GLY 71  51  51  GLY GLY B . n 
B 1 72  GLY 72  52  52  GLY GLY B . n 
B 1 73  LEU 73  53  53  LEU LEU B . n 
B 1 74  TRP 74  54  54  TRP TRP B . n 
B 1 75  THR 75  55  55  THR THR B . n 
B 1 76  THR 76  56  56  THR THR B . n 
B 1 77  ASP 77  57  57  ASP ASP B . n 
B 1 78  SER 78  58  58  SER SER B . n 
B 1 79  GLY 79  59  59  GLY GLY B . n 
B 1 80  GLN 80  60  60  GLN GLN B . n 
B 1 81  PRO 81  61  61  PRO PRO B . n 
B 1 82  ILE 82  62  62  ILE ILE B . n 
B 1 83  ALA 83  63  63  ALA ALA B . n 
B 1 84  ILE 84  64  64  ILE ILE B . n 
B 1 85  ARG 85  65  65  ARG ARG B . n 
B 1 86  GLY 86  66  66  GLY GLY B . n 
B 1 87  ARG 87  67  67  ARG ARG B . n 
B 1 88  GLU 88  68  68  GLU GLU B . n 
B 1 89  LYS 89  69  69  LYS LYS B . n 
B 1 90  LEU 90  70  70  LEU LEU B . n 
B 1 91  GLY 91  71  71  GLY GLY B . n 
B 1 92  GLU 92  72  72  GLU GLU B . n 
B 1 93  HIS 93  73  73  HIS HIS B . n 
B 1 94  ALA 94  74  74  ALA ALA B . n 
B 1 95  VAL 95  75  75  VAL VAL B . n 
B 1 96  TRP 96  76  76  TRP TRP B . n 
B 1 97  SER 97  77  77  SER SER B . n 
B 1 98  LEU 98  78  78  LEU LEU B . n 
B 1 99  GLN 99  79  79  GLN GLN B . n 
B 1 100 CYS 100 80  80  CYS CYS B . n 
B 1 101 PHE 101 81  81  PHE PHE B . n 
B 1 102 PRO 102 82  82  PRO PRO B . n 
B 1 103 ASP 103 83  83  ASP ASP B . n 
B 1 104 TRP 104 84  84  TRP TRP B . n 
B 1 105 VAL 105 85  85  VAL VAL B . n 
B 1 106 TRP 106 86  86  TRP TRP B . n 
B 1 107 THR 107 87  87  THR THR B . n 
B 1 108 ASP 108 88  88  ASP ASP B . n 
B 1 109 ILE 109 89  89  ILE ILE B . n 
B 1 110 GLN 110 90  90  GLN GLN B . n 
B 1 111 ILE 111 91  91  ILE ILE B . n 
B 1 112 PHE 112 92  92  PHE PHE B . n 
B 1 113 GLU 113 93  93  GLU GLU B . n 
B 1 114 THR 114 94  94  THR THR B . n 
B 1 115 GLN 115 95  95  GLN GLN B . n 
B 1 116 ASP 116 96  96  ASP ASP B . n 
B 1 117 PRO 117 97  97  PRO PRO B . n 
B 1 118 ASN 118 98  98  ASN ASN B . n 
B 1 119 TRP 119 99  99  TRP TRP B . n 
B 1 120 PHE 120 100 100 PHE PHE B . n 
B 1 121 TRP 121 101 101 TRP TRP B . n 
B 1 122 VAL 122 102 102 VAL VAL B . n 
B 1 123 GLU 123 103 103 GLU GLU B . n 
B 1 124 CYS 124 104 104 CYS CYS B . n 
B 1 125 ARG 125 105 105 ARG ARG B . n 
B 1 126 GLY 126 106 106 GLY GLY B . n 
B 1 127 GLU 127 107 107 GLU GLU B . n 
B 1 128 GLY 128 108 108 GLY GLY B . n 
B 1 129 ALA 129 109 109 ALA ALA B . n 
B 1 130 ILE 130 110 110 ILE ILE B . n 
B 1 131 VAL 131 111 111 VAL VAL B . n 
B 1 132 PHE 132 112 112 PHE PHE B . n 
B 1 133 PRO 133 113 113 PRO PRO B . n 
B 1 134 GLY 134 114 114 GLY GLY B . n 
B 1 135 TYR 135 115 115 TYR TYR B . n 
B 1 136 PRO 136 116 116 PRO PRO B . n 
B 1 137 ARG 137 117 117 ARG ARG B . n 
B 1 138 GLY 138 118 118 GLY GLY B . n 
B 1 139 GLN 139 119 119 GLN GLN B . n 
B 1 140 TYR 140 120 120 TYR TYR B . n 
B 1 141 ARG 141 121 121 ARG ARG B . n 
B 1 142 ASN 142 122 122 ASN ASN B . n 
B 1 143 HIS 143 123 123 HIS HIS B . n 
B 1 144 PHE 144 124 124 PHE PHE B . n 
B 1 145 LEU 145 125 125 LEU LEU B . n 
B 1 146 HIS 146 126 126 HIS HIS B . n 
B 1 147 SER 147 127 127 SER SER B . n 
B 1 148 PHE 148 128 128 PHE PHE B . n 
B 1 149 ARG 149 129 129 ARG ARG B . n 
B 1 150 PHE 150 130 130 PHE PHE B . n 
B 1 151 GLU 151 131 131 GLU GLU B . n 
B 1 152 ASN 152 132 132 ASN ASN B . n 
B 1 153 GLY 153 133 133 GLY GLY B . n 
B 1 154 LEU 154 134 134 LEU LEU B . n 
B 1 155 ILE 155 135 135 ILE ILE B . n 
B 1 156 LYS 156 136 136 LYS LYS B . n 
B 1 157 GLU 157 137 137 GLU GLU B . n 
B 1 158 GLN 158 138 138 GLN GLN B . n 
B 1 159 ARG 159 139 139 ARG ARG B . n 
B 1 160 GLU 160 140 140 GLU GLU B . n 
B 1 161 PHE 161 141 141 PHE PHE B . n 
B 1 162 MET 162 142 142 MET MET B . n 
B 1 163 ASN 163 143 143 ASN ASN B . n 
B 1 164 PRO 164 144 144 PRO PRO B . n 
B 1 165 CYS 165 145 145 CYS CYS B . n 
B 1 166 GLU 166 146 146 GLU GLU B . n 
B 1 167 GLN 167 147 147 GLN GLN B . n 
B 1 168 PHE 168 148 148 PHE PHE B . n 
B 1 169 ARG 169 149 149 ARG ARG B . n 
B 1 170 SER 170 150 150 SER SER B . n 
B 1 171 LEU 171 151 151 LEU LEU B . n 
B 1 172 GLY 172 152 152 GLY GLY B . n 
B 1 173 ILE 173 153 153 ILE ILE B . n 
B 1 174 GLU 174 154 154 GLU GLU B . n 
B 1 175 VAL 175 155 155 VAL VAL B . n 
B 1 176 PRO 176 156 156 PRO PRO B . n 
B 1 177 GLU 177 157 157 GLU GLU B . n 
B 1 178 VAL 178 158 158 VAL VAL B . n 
B 1 179 ARG 179 159 159 ARG ARG B . n 
B 1 180 ARG 180 160 160 ARG ARG B . n 
B 1 181 ASP 181 161 161 ASP ASP B . n 
B 1 182 GLY 182 162 162 GLY GLY B . n 
B 1 183 LEU 183 163 163 LEU LEU B . n 
B 1 184 PRO 184 164 164 PRO PRO B . n 
B 1 185 SER 185 165 165 SER SER B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1IAM 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1IAM 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 GOL   1   201 202 GOL   GOL A . 
D 2 GOL   1   202 204 GOL   GOL A . 
E 3 A1IAM 1   203 210 A1IAM Z74 A . 
F 2 GOL   1   201 202 GOL   GOL B . 
G 3 A1IAM 1   202 206 A1IAM Z74 B . 
H 4 HOH   1   301 99  HOH   HOH A . 
H 4 HOH   2   302 34  HOH   HOH A . 
H 4 HOH   3   303 88  HOH   HOH A . 
H 4 HOH   4   304 63  HOH   HOH A . 
H 4 HOH   5   305 347 HOH   HOH A . 
H 4 HOH   6   306 194 HOH   HOH A . 
H 4 HOH   7   307 29  HOH   HOH A . 
H 4 HOH   8   308 229 HOH   HOH A . 
H 4 HOH   9   309 233 HOH   HOH A . 
H 4 HOH   10  310 101 HOH   HOH A . 
H 4 HOH   11  311 111 HOH   HOH A . 
H 4 HOH   12  312 151 HOH   HOH A . 
H 4 HOH   13  313 165 HOH   HOH A . 
H 4 HOH   14  314 70  HOH   HOH A . 
H 4 HOH   15  315 246 HOH   HOH A . 
H 4 HOH   16  316 20  HOH   HOH A . 
H 4 HOH   17  317 136 HOH   HOH A . 
H 4 HOH   18  318 12  HOH   HOH A . 
H 4 HOH   19  319 126 HOH   HOH A . 
H 4 HOH   20  320 97  HOH   HOH A . 
H 4 HOH   21  321 174 HOH   HOH A . 
H 4 HOH   22  322 35  HOH   HOH A . 
H 4 HOH   23  323 69  HOH   HOH A . 
H 4 HOH   24  324 30  HOH   HOH A . 
H 4 HOH   25  325 10  HOH   HOH A . 
H 4 HOH   26  326 3   HOH   HOH A . 
H 4 HOH   27  327 77  HOH   HOH A . 
H 4 HOH   28  328 143 HOH   HOH A . 
H 4 HOH   29  329 13  HOH   HOH A . 
H 4 HOH   30  330 83  HOH   HOH A . 
H 4 HOH   31  331 2   HOH   HOH A . 
H 4 HOH   32  332 265 HOH   HOH A . 
H 4 HOH   33  333 23  HOH   HOH A . 
H 4 HOH   34  334 326 HOH   HOH A . 
H 4 HOH   35  335 266 HOH   HOH A . 
H 4 HOH   36  336 276 HOH   HOH A . 
H 4 HOH   37  337 56  HOH   HOH A . 
H 4 HOH   38  338 19  HOH   HOH A . 
H 4 HOH   39  339 66  HOH   HOH A . 
H 4 HOH   40  340 257 HOH   HOH A . 
H 4 HOH   41  341 167 HOH   HOH A . 
H 4 HOH   42  342 199 HOH   HOH A . 
H 4 HOH   43  343 51  HOH   HOH A . 
H 4 HOH   44  344 36  HOH   HOH A . 
H 4 HOH   45  345 258 HOH   HOH A . 
H 4 HOH   46  346 212 HOH   HOH A . 
H 4 HOH   47  347 184 HOH   HOH A . 
H 4 HOH   48  348 32  HOH   HOH A . 
H 4 HOH   49  349 62  HOH   HOH A . 
H 4 HOH   50  350 275 HOH   HOH A . 
H 4 HOH   51  351 173 HOH   HOH A . 
H 4 HOH   52  352 31  HOH   HOH A . 
H 4 HOH   53  353 144 HOH   HOH A . 
H 4 HOH   54  354 293 HOH   HOH A . 
H 4 HOH   55  355 203 HOH   HOH A . 
H 4 HOH   56  356 67  HOH   HOH A . 
H 4 HOH   57  357 109 HOH   HOH A . 
H 4 HOH   58  358 119 HOH   HOH A . 
H 4 HOH   59  359 224 HOH   HOH A . 
H 4 HOH   60  360 87  HOH   HOH A . 
H 4 HOH   61  361 161 HOH   HOH A . 
H 4 HOH   62  362 152 HOH   HOH A . 
H 4 HOH   63  363 145 HOH   HOH A . 
H 4 HOH   64  364 259 HOH   HOH A . 
H 4 HOH   65  365 53  HOH   HOH A . 
H 4 HOH   66  366 175 HOH   HOH A . 
H 4 HOH   67  367 198 HOH   HOH A . 
H 4 HOH   68  368 48  HOH   HOH A . 
H 4 HOH   69  369 64  HOH   HOH A . 
H 4 HOH   70  370 98  HOH   HOH A . 
H 4 HOH   71  371 124 HOH   HOH A . 
H 4 HOH   72  372 228 HOH   HOH A . 
H 4 HOH   73  373 92  HOH   HOH A . 
H 4 HOH   74  374 43  HOH   HOH A . 
H 4 HOH   75  375 59  HOH   HOH A . 
H 4 HOH   76  376 223 HOH   HOH A . 
H 4 HOH   77  377 55  HOH   HOH A . 
H 4 HOH   78  378 360 HOH   HOH A . 
H 4 HOH   79  379 74  HOH   HOH A . 
H 4 HOH   80  380 76  HOH   HOH A . 
H 4 HOH   81  381 134 HOH   HOH A . 
H 4 HOH   82  382 120 HOH   HOH A . 
H 4 HOH   83  383 226 HOH   HOH A . 
H 4 HOH   84  384 256 HOH   HOH A . 
H 4 HOH   85  385 356 HOH   HOH A . 
H 4 HOH   86  386 320 HOH   HOH A . 
H 4 HOH   87  387 215 HOH   HOH A . 
H 4 HOH   88  388 294 HOH   HOH A . 
H 4 HOH   89  389 302 HOH   HOH A . 
H 4 HOH   90  390 100 HOH   HOH A . 
H 4 HOH   91  391 114 HOH   HOH A . 
H 4 HOH   92  392 16  HOH   HOH A . 
H 4 HOH   93  393 105 HOH   HOH A . 
H 4 HOH   94  394 283 HOH   HOH A . 
H 4 HOH   95  395 61  HOH   HOH A . 
H 4 HOH   96  396 213 HOH   HOH A . 
H 4 HOH   97  397 342 HOH   HOH A . 
H 4 HOH   98  398 11  HOH   HOH A . 
H 4 HOH   99  399 170 HOH   HOH A . 
H 4 HOH   100 400 344 HOH   HOH A . 
H 4 HOH   101 401 350 HOH   HOH A . 
H 4 HOH   102 402 353 HOH   HOH A . 
H 4 HOH   103 403 328 HOH   HOH A . 
H 4 HOH   104 404 305 HOH   HOH A . 
H 4 HOH   105 405 140 HOH   HOH A . 
H 4 HOH   106 406 255 HOH   HOH A . 
H 4 HOH   107 407 183 HOH   HOH A . 
H 4 HOH   108 408 231 HOH   HOH A . 
H 4 HOH   109 409 179 HOH   HOH A . 
H 4 HOH   110 410 352 HOH   HOH A . 
H 4 HOH   111 411 113 HOH   HOH A . 
H 4 HOH   112 412 206 HOH   HOH A . 
H 4 HOH   113 413 359 HOH   HOH A . 
H 4 HOH   114 414 153 HOH   HOH A . 
H 4 HOH   115 415 128 HOH   HOH A . 
H 4 HOH   116 416 295 HOH   HOH A . 
H 4 HOH   117 417 75  HOH   HOH A . 
H 4 HOH   118 418 210 HOH   HOH A . 
H 4 HOH   119 419 180 HOH   HOH A . 
H 4 HOH   120 420 274 HOH   HOH A . 
H 4 HOH   121 421 351 HOH   HOH A . 
H 4 HOH   122 422 129 HOH   HOH A . 
H 4 HOH   123 423 314 HOH   HOH A . 
H 4 HOH   124 424 162 HOH   HOH A . 
H 4 HOH   125 425 248 HOH   HOH A . 
H 4 HOH   126 426 316 HOH   HOH A . 
H 4 HOH   127 427 218 HOH   HOH A . 
H 4 HOH   128 428 115 HOH   HOH A . 
H 4 HOH   129 429 362 HOH   HOH A . 
I 4 HOH   1   301 355 HOH   HOH B . 
I 4 HOH   2   302 310 HOH   HOH B . 
I 4 HOH   3   303 313 HOH   HOH B . 
I 4 HOH   4   304 156 HOH   HOH B . 
I 4 HOH   5   305 118 HOH   HOH B . 
I 4 HOH   6   306 358 HOH   HOH B . 
I 4 HOH   7   307 89  HOH   HOH B . 
I 4 HOH   8   308 154 HOH   HOH B . 
I 4 HOH   9   309 130 HOH   HOH B . 
I 4 HOH   10  310 1   HOH   HOH B . 
I 4 HOH   11  311 7   HOH   HOH B . 
I 4 HOH   12  312 107 HOH   HOH B . 
I 4 HOH   13  313 28  HOH   HOH B . 
I 4 HOH   14  314 25  HOH   HOH B . 
I 4 HOH   15  315 292 HOH   HOH B . 
I 4 HOH   16  316 348 HOH   HOH B . 
I 4 HOH   17  317 54  HOH   HOH B . 
I 4 HOH   18  318 21  HOH   HOH B . 
I 4 HOH   19  319 163 HOH   HOH B . 
I 4 HOH   20  320 110 HOH   HOH B . 
I 4 HOH   21  321 357 HOH   HOH B . 
I 4 HOH   22  322 102 HOH   HOH B . 
I 4 HOH   23  323 217 HOH   HOH B . 
I 4 HOH   24  324 50  HOH   HOH B . 
I 4 HOH   25  325 6   HOH   HOH B . 
I 4 HOH   26  326 45  HOH   HOH B . 
I 4 HOH   27  327 9   HOH   HOH B . 
I 4 HOH   28  328 354 HOH   HOH B . 
I 4 HOH   29  329 4   HOH   HOH B . 
I 4 HOH   30  330 116 HOH   HOH B . 
I 4 HOH   31  331 132 HOH   HOH B . 
I 4 HOH   32  332 68  HOH   HOH B . 
I 4 HOH   33  333 14  HOH   HOH B . 
I 4 HOH   34  334 5   HOH   HOH B . 
I 4 HOH   35  335 207 HOH   HOH B . 
I 4 HOH   36  336 159 HOH   HOH B . 
I 4 HOH   37  337 298 HOH   HOH B . 
I 4 HOH   38  338 121 HOH   HOH B . 
I 4 HOH   39  339 96  HOH   HOH B . 
I 4 HOH   40  340 242 HOH   HOH B . 
I 4 HOH   41  341 117 HOH   HOH B . 
I 4 HOH   42  342 37  HOH   HOH B . 
I 4 HOH   43  343 147 HOH   HOH B . 
I 4 HOH   44  344 42  HOH   HOH B . 
I 4 HOH   45  345 208 HOH   HOH B . 
I 4 HOH   46  346 38  HOH   HOH B . 
I 4 HOH   47  347 196 HOH   HOH B . 
I 4 HOH   48  348 177 HOH   HOH B . 
I 4 HOH   49  349 65  HOH   HOH B . 
I 4 HOH   50  350 8   HOH   HOH B . 
I 4 HOH   51  351 91  HOH   HOH B . 
I 4 HOH   52  352 158 HOH   HOH B . 
I 4 HOH   53  353 80  HOH   HOH B . 
I 4 HOH   54  354 46  HOH   HOH B . 
I 4 HOH   55  355 214 HOH   HOH B . 
I 4 HOH   56  356 93  HOH   HOH B . 
I 4 HOH   57  357 49  HOH   HOH B . 
I 4 HOH   58  358 232 HOH   HOH B . 
I 4 HOH   59  359 52  HOH   HOH B . 
I 4 HOH   60  360 82  HOH   HOH B . 
I 4 HOH   61  361 185 HOH   HOH B . 
I 4 HOH   62  362 78  HOH   HOH B . 
I 4 HOH   63  363 141 HOH   HOH B . 
I 4 HOH   64  364 281 HOH   HOH B . 
I 4 HOH   65  365 44  HOH   HOH B . 
I 4 HOH   66  366 155 HOH   HOH B . 
I 4 HOH   67  367 22  HOH   HOH B . 
I 4 HOH   68  368 296 HOH   HOH B . 
I 4 HOH   69  369 72  HOH   HOH B . 
I 4 HOH   70  370 338 HOH   HOH B . 
I 4 HOH   71  371 41  HOH   HOH B . 
I 4 HOH   72  372 86  HOH   HOH B . 
I 4 HOH   73  373 123 HOH   HOH B . 
I 4 HOH   74  374 79  HOH   HOH B . 
I 4 HOH   75  375 106 HOH   HOH B . 
I 4 HOH   76  376 331 HOH   HOH B . 
I 4 HOH   77  377 39  HOH   HOH B . 
I 4 HOH   78  378 58  HOH   HOH B . 
I 4 HOH   79  379 270 HOH   HOH B . 
I 4 HOH   80  380 137 HOH   HOH B . 
I 4 HOH   81  381 345 HOH   HOH B . 
I 4 HOH   82  382 94  HOH   HOH B . 
I 4 HOH   83  383 324 HOH   HOH B . 
I 4 HOH   84  384 312 HOH   HOH B . 
I 4 HOH   85  385 135 HOH   HOH B . 
I 4 HOH   86  386 220 HOH   HOH B . 
I 4 HOH   87  387 200 HOH   HOH B . 
I 4 HOH   88  388 57  HOH   HOH B . 
I 4 HOH   89  389 263 HOH   HOH B . 
I 4 HOH   90  390 268 HOH   HOH B . 
I 4 HOH   91  391 267 HOH   HOH B . 
I 4 HOH   92  392 278 HOH   HOH B . 
I 4 HOH   93  393 18  HOH   HOH B . 
I 4 HOH   94  394 47  HOH   HOH B . 
I 4 HOH   95  395 346 HOH   HOH B . 
I 4 HOH   96  396 176 HOH   HOH B . 
I 4 HOH   97  397 322 HOH   HOH B . 
I 4 HOH   98  398 90  HOH   HOH B . 
I 4 HOH   99  399 84  HOH   HOH B . 
I 4 HOH   100 400 361 HOH   HOH B . 
I 4 HOH   101 401 323 HOH   HOH B . 
I 4 HOH   102 402 301 HOH   HOH B . 
I 4 HOH   103 403 26  HOH   HOH B . 
I 4 HOH   104 404 262 HOH   HOH B . 
I 4 HOH   105 405 333 HOH   HOH B . 
I 4 HOH   106 406 334 HOH   HOH B . 
I 4 HOH   107 407 190 HOH   HOH B . 
I 4 HOH   108 408 325 HOH   HOH B . 
I 4 HOH   109 409 363 HOH   HOH B . 
I 4 HOH   110 410 321 HOH   HOH B . 
I 4 HOH   111 411 187 HOH   HOH B . 
I 4 HOH   112 412 181 HOH   HOH B . 
I 4 HOH   113 413 191 HOH   HOH B . 
I 4 HOH   114 414 280 HOH   HOH B . 
I 4 HOH   115 415 238 HOH   HOH B . 
I 4 HOH   116 416 330 HOH   HOH B . 
I 4 HOH   117 417 138 HOH   HOH B . 
I 4 HOH   118 418 336 HOH   HOH B . 
I 4 HOH   119 419 271 HOH   HOH B . 
I 4 HOH   120 420 230 HOH   HOH B . 
I 4 HOH   121 421 182 HOH   HOH B . 
I 4 HOH   122 422 73  HOH   HOH B . 
I 4 HOH   123 423 289 HOH   HOH B . 
I 4 HOH   124 424 340 HOH   HOH B . 
I 4 HOH   125 425 349 HOH   HOH B . 
I 4 HOH   126 426 240 HOH   HOH B . 
I 4 HOH   127 427 317 HOH   HOH B . 
I 4 HOH   128 428 241 HOH   HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 12  ? CG  ? A GLU 32  CG  
2  1 Y 1 A GLU 12  ? CD  ? A GLU 32  CD  
3  1 Y 1 A GLU 12  ? OE1 ? A GLU 32  OE1 
4  1 Y 1 A GLU 12  ? OE2 ? A GLU 32  OE2 
5  1 Y 1 A ASN 13  ? CG  ? A ASN 33  CG  
6  1 Y 1 A ASN 13  ? OD1 ? A ASN 33  OD1 
7  1 Y 1 A ASN 13  ? ND2 ? A ASN 33  ND2 
8  1 Y 1 A ARG 14  ? CG  ? A ARG 34  CG  
9  1 Y 1 A ARG 14  ? CD  ? A ARG 34  CD  
10 1 Y 1 A ARG 14  ? NE  ? A ARG 34  NE  
11 1 Y 1 A ARG 14  ? CZ  ? A ARG 34  CZ  
12 1 Y 1 A ARG 14  ? NH1 ? A ARG 34  NH1 
13 1 Y 1 A ARG 14  ? NH2 ? A ARG 34  NH2 
14 1 Y 1 A LYS 25  ? CD  ? A LYS 45  CD  
15 1 Y 1 A LYS 25  ? CE  ? A LYS 45  CE  
16 1 Y 1 A LYS 25  ? NZ  ? A LYS 45  NZ  
17 1 Y 1 A LYS 40  ? CD  ? A LYS 60  CD  
18 1 Y 1 A LYS 40  ? CE  ? A LYS 60  CE  
19 1 Y 1 A LYS 40  ? NZ  ? A LYS 60  NZ  
20 1 Y 1 A GLU 68  ? CG  ? A GLU 88  CG  
21 1 Y 1 A GLU 68  ? CD  ? A GLU 88  CD  
22 1 Y 1 A GLU 68  ? OE1 ? A GLU 88  OE1 
23 1 Y 1 A GLU 68  ? OE2 ? A GLU 88  OE2 
24 1 Y 1 A LYS 69  ? CD  ? A LYS 89  CD  
25 1 Y 1 A LYS 69  ? CE  ? A LYS 89  CE  
26 1 Y 1 A LYS 69  ? NZ  ? A LYS 89  NZ  
27 1 Y 1 A TRP 76  ? CG  ? A TRP 96  CG  
28 1 Y 1 A TRP 76  ? CD1 ? A TRP 96  CD1 
29 1 Y 1 A TRP 76  ? CD2 ? A TRP 96  CD2 
30 1 Y 1 A TRP 76  ? NE1 ? A TRP 96  NE1 
31 1 Y 1 A TRP 76  ? CE2 ? A TRP 96  CE2 
32 1 Y 1 A TRP 76  ? CE3 ? A TRP 96  CE3 
33 1 Y 1 A TRP 76  ? CZ2 ? A TRP 96  CZ2 
34 1 Y 1 A TRP 76  ? CZ3 ? A TRP 96  CZ3 
35 1 Y 1 A TRP 76  ? CH2 ? A TRP 96  CH2 
36 1 Y 1 A GLU 154 ? CG  ? A GLU 174 CG  
37 1 Y 1 A GLU 154 ? CD  ? A GLU 174 CD  
38 1 Y 1 A GLU 154 ? OE1 ? A GLU 174 OE1 
39 1 Y 1 A GLU 154 ? OE2 ? A GLU 174 OE2 
40 1 Y 1 A GLU 157 ? CG  ? A GLU 177 CG  
41 1 Y 1 A GLU 157 ? CD  ? A GLU 177 CD  
42 1 Y 1 A GLU 157 ? OE1 ? A GLU 177 OE1 
43 1 Y 1 A GLU 157 ? OE2 ? A GLU 177 OE2 
44 1 Y 1 A SER 165 ? OG  ? A SER 185 OG  
45 1 Y 1 B GLU 12  ? CG  ? B GLU 32  CG  
46 1 Y 1 B GLU 12  ? CD  ? B GLU 32  CD  
47 1 Y 1 B GLU 12  ? OE1 ? B GLU 32  OE1 
48 1 Y 1 B GLU 12  ? OE2 ? B GLU 32  OE2 
49 1 Y 1 B ASN 13  ? CG  ? B ASN 33  CG  
50 1 Y 1 B ASN 13  ? OD1 ? B ASN 33  OD1 
51 1 Y 1 B ASN 13  ? ND2 ? B ASN 33  ND2 
52 1 Y 1 B ARG 14  ? CG  ? B ARG 34  CG  
53 1 Y 1 B ARG 14  ? CD  ? B ARG 34  CD  
54 1 Y 1 B ARG 14  ? NE  ? B ARG 34  NE  
55 1 Y 1 B ARG 14  ? CZ  ? B ARG 34  CZ  
56 1 Y 1 B ARG 14  ? NH1 ? B ARG 34  NH1 
57 1 Y 1 B ARG 14  ? NH2 ? B ARG 34  NH2 
58 1 Y 1 B GLN 16  ? CD  ? B GLN 36  CD  
59 1 Y 1 B GLN 16  ? OE1 ? B GLN 36  OE1 
60 1 Y 1 B GLN 16  ? NE2 ? B GLN 36  NE2 
61 1 Y 1 B GLN 21  ? CG  ? B GLN 41  CG  
62 1 Y 1 B GLN 21  ? CD  ? B GLN 41  CD  
63 1 Y 1 B GLN 21  ? OE1 ? B GLN 41  OE1 
64 1 Y 1 B GLN 21  ? NE2 ? B GLN 41  NE2 
65 1 Y 1 B LYS 25  ? CD  ? B LYS 45  CD  
66 1 Y 1 B LYS 25  ? CE  ? B LYS 45  CE  
67 1 Y 1 B LYS 25  ? NZ  ? B LYS 45  NZ  
68 1 Y 1 B GLU 68  ? CG  ? B GLU 88  CG  
69 1 Y 1 B GLU 68  ? CD  ? B GLU 88  CD  
70 1 Y 1 B GLU 68  ? OE1 ? B GLU 88  OE1 
71 1 Y 1 B GLU 68  ? OE2 ? B GLU 88  OE2 
72 1 Y 1 B LYS 69  ? CD  ? B LYS 89  CD  
73 1 Y 1 B LYS 69  ? CE  ? B LYS 89  CE  
74 1 Y 1 B LYS 69  ? NZ  ? B LYS 89  NZ  
75 1 Y 1 B TRP 76  ? CG  ? B TRP 96  CG  
76 1 Y 1 B TRP 76  ? CD1 ? B TRP 96  CD1 
77 1 Y 1 B TRP 76  ? CD2 ? B TRP 96  CD2 
78 1 Y 1 B TRP 76  ? NE1 ? B TRP 96  NE1 
79 1 Y 1 B TRP 76  ? CE2 ? B TRP 96  CE2 
80 1 Y 1 B TRP 76  ? CE3 ? B TRP 96  CE3 
81 1 Y 1 B TRP 76  ? CZ2 ? B TRP 96  CZ2 
82 1 Y 1 B TRP 76  ? CZ3 ? B TRP 96  CZ3 
83 1 Y 1 B TRP 76  ? CH2 ? B TRP 96  CH2 
84 1 Y 1 B GLN 79  ? CG  ? B GLN 99  CG  
85 1 Y 1 B GLN 79  ? CD  ? B GLN 99  CD  
86 1 Y 1 B GLN 79  ? OE1 ? B GLN 99  OE1 
87 1 Y 1 B GLN 79  ? NE2 ? B GLN 99  NE2 
88 1 Y 1 B GLU 154 ? CG  ? B GLU 174 CG  
89 1 Y 1 B GLU 154 ? CD  ? B GLU 174 CD  
90 1 Y 1 B GLU 154 ? OE1 ? B GLU 174 OE1 
91 1 Y 1 B GLU 154 ? OE2 ? B GLU 174 OE2 
92 1 Y 1 B SER 165 ? OG  ? B SER 185 OG  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS         ? ? ? 'Jun 30, 2023'      1 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? v0.7.15             2 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? v2.8.3              3 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? v1.20.1-4487        4 
? 'data processing' ? ? ? ? ? ? ? ? ? ? ? autoPROC    ? ? ? 'v1.0.5 (20240123)' 5 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? v4.2                6 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   100.31 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9F8S 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     54.018 
_cell.length_a_esd                 ? 
_cell.length_b                     68.900 
_cell.length_b_esd                 ? 
_cell.length_c                     54.082 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9F8S 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9F8S 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.38 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          48.3 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '25% (w/v) PEG 3350, 0.1M Bis-TRIS pH 5.99, 0.15 M lithium sulfate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0331 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PETRA III, DESY BEAMLINE P11' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0331 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   P11 
_diffrn_source.pdbx_synchrotron_site       'PETRA III, DESY' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9F8S 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.69 
_reflns.d_resolution_low                               53.15 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     43245 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.2 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.133 
_reflns.pdbx_Rpim_I_all                                0.049 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.995 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.123 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.69 
_reflns_shell.d_res_low                                     1.72 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.1 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2094 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.7 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               1.103 
_reflns_shell.pdbx_Rpim_I_all                               0.421 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.885 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.018 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               22.963 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9F8S 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.69 
_refine.ls_d_res_low                             53.15 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     43215 
_refine.ls_number_reflns_R_free                  2141 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.10 
_refine.ls_percent_reflns_R_free                 4.95 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1682 
_refine.ls_R_factor_R_free                       0.1889 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1671 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 19.82 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.17 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2475 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         68 
_refine_hist.number_atoms_solvent             257 
_refine_hist.number_atoms_total               2800 
_refine_hist.d_res_high                       1.69 
_refine_hist.d_res_low                        53.15 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.005  ? 2663 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.763  ? 3615 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 14.434 ? 999  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.052  ? 350  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.009  ? 501  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.69 1.72  . . 143 2667 97.00  . . . . 0.2378 . . . . . . . . . . . 0.3177 
'X-RAY DIFFRACTION' 1.72 1.77  . . 122 2613 93.00  . . . . 0.2251 . . . . . . . . . . . 0.2459 
'X-RAY DIFFRACTION' 1.77 1.82  . . 136 2741 99.00  . . . . 0.1832 . . . . . . . . . . . 0.2403 
'X-RAY DIFFRACTION' 1.82 1.87  . . 168 2744 99.00  . . . . 0.1754 . . . . . . . . . . . 0.2078 
'X-RAY DIFFRACTION' 1.87 1.93  . . 154 2738 99.00  . . . . 0.1683 . . . . . . . . . . . 0.1876 
'X-RAY DIFFRACTION' 1.93 2.00  . . 127 2754 99.00  . . . . 0.1698 . . . . . . . . . . . 0.2149 
'X-RAY DIFFRACTION' 2.00 2.08  . . 139 2766 99.00  . . . . 0.1741 . . . . . . . . . . . 0.2120 
'X-RAY DIFFRACTION' 2.08 2.17  . . 111 2769 99.00  . . . . 0.1604 . . . . . . . . . . . 0.1890 
'X-RAY DIFFRACTION' 2.17 2.29  . . 148 2745 99.00  . . . . 0.1569 . . . . . . . . . . . 0.1993 
'X-RAY DIFFRACTION' 2.29 2.43  . . 159 2661 96.00  . . . . 0.1537 . . . . . . . . . . . 0.1916 
'X-RAY DIFFRACTION' 2.43 2.62  . . 132 2694 97.00  . . . . 0.1586 . . . . . . . . . . . 0.1678 
'X-RAY DIFFRACTION' 2.62 2.88  . . 152 2802 100.00 . . . . 0.1625 . . . . . . . . . . . 0.1629 
'X-RAY DIFFRACTION' 2.88 3.30  . . 168 2770 100.00 . . . . 0.1630 . . . . . . . . . . . 0.1772 
'X-RAY DIFFRACTION' 3.30 4.16  . . 130 2829 99.00  . . . . 0.1442 . . . . . . . . . . . 0.1624 
'X-RAY DIFFRACTION' 4.16 53.15 . . 152 2781 98.00  . . . . 0.1844 . . . . . . . . . . . 0.1898 
# 
_struct.entry_id                     9F8S 
_struct.title                        
;Crystal Structure of PhzA/B from Burkholderia cepacia R18194 in complex with (4-Chlorophenyl)[6-hydroxy-2-phenylbenzo[b]thiophen-3-yl]methanone
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9F8S 
_struct_keywords.text            
;pyocyanin, phenazine biosynthesis, virulence, inhibitor, ketosteroid-isomerase, cocrystal, PhzA/B, Burkholderia cepacia, BIOSYNTHETIC PROTEIN
;
_struct_keywords.pdbx_keywords   'BIOSYNTHETIC PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 2 ? 
G N N 3 ? 
H N N 4 ? 
I N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q396C9_BURL3 
_struct_ref.pdbx_db_accession          Q396C9 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSDVESLENTSENRAQVAARQHNRKIVEQYMHTRGEARLKRHLLFTEDGVGGLWTTDSGQPIAIRGREKLGEHAVWSLQC
FPDWVWTDIQIFETQDPNWFWVECRGEGAIVFPGYPRGQYRNHFLHSFRFENGLIKEQREFMNPCEQFRSLGIEVPEVRR
DGLPS
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9F8S A 21 ? 185 ? Q396C9 1 ? 165 ? 1 165 
2 1 9F8S B 21 ? 185 ? Q396C9 1 ? 165 ? 1 165 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9F8S MET A 1  ? UNP Q396C9 ? ? 'initiating methionine' -19 1  
1 9F8S GLY A 2  ? UNP Q396C9 ? ? 'expression tag'        -18 2  
1 9F8S SER A 3  ? UNP Q396C9 ? ? 'expression tag'        -17 3  
1 9F8S SER A 4  ? UNP Q396C9 ? ? 'expression tag'        -16 4  
1 9F8S HIS A 5  ? UNP Q396C9 ? ? 'expression tag'        -15 5  
1 9F8S HIS A 6  ? UNP Q396C9 ? ? 'expression tag'        -14 6  
1 9F8S HIS A 7  ? UNP Q396C9 ? ? 'expression tag'        -13 7  
1 9F8S HIS A 8  ? UNP Q396C9 ? ? 'expression tag'        -12 8  
1 9F8S HIS A 9  ? UNP Q396C9 ? ? 'expression tag'        -11 9  
1 9F8S HIS A 10 ? UNP Q396C9 ? ? 'expression tag'        -10 10 
1 9F8S SER A 11 ? UNP Q396C9 ? ? 'expression tag'        -9  11 
1 9F8S SER A 12 ? UNP Q396C9 ? ? 'expression tag'        -8  12 
1 9F8S GLY A 13 ? UNP Q396C9 ? ? 'expression tag'        -7  13 
1 9F8S LEU A 14 ? UNP Q396C9 ? ? 'expression tag'        -6  14 
1 9F8S VAL A 15 ? UNP Q396C9 ? ? 'expression tag'        -5  15 
1 9F8S PRO A 16 ? UNP Q396C9 ? ? 'expression tag'        -4  16 
1 9F8S ARG A 17 ? UNP Q396C9 ? ? 'expression tag'        -3  17 
1 9F8S GLY A 18 ? UNP Q396C9 ? ? 'expression tag'        -2  18 
1 9F8S SER A 19 ? UNP Q396C9 ? ? 'expression tag'        -1  19 
1 9F8S HIS A 20 ? UNP Q396C9 ? ? 'expression tag'        0   20 
2 9F8S MET B 1  ? UNP Q396C9 ? ? 'initiating methionine' -19 21 
2 9F8S GLY B 2  ? UNP Q396C9 ? ? 'expression tag'        -18 22 
2 9F8S SER B 3  ? UNP Q396C9 ? ? 'expression tag'        -17 23 
2 9F8S SER B 4  ? UNP Q396C9 ? ? 'expression tag'        -16 24 
2 9F8S HIS B 5  ? UNP Q396C9 ? ? 'expression tag'        -15 25 
2 9F8S HIS B 6  ? UNP Q396C9 ? ? 'expression tag'        -14 26 
2 9F8S HIS B 7  ? UNP Q396C9 ? ? 'expression tag'        -13 27 
2 9F8S HIS B 8  ? UNP Q396C9 ? ? 'expression tag'        -12 28 
2 9F8S HIS B 9  ? UNP Q396C9 ? ? 'expression tag'        -11 29 
2 9F8S HIS B 10 ? UNP Q396C9 ? ? 'expression tag'        -10 30 
2 9F8S SER B 11 ? UNP Q396C9 ? ? 'expression tag'        -9  31 
2 9F8S SER B 12 ? UNP Q396C9 ? ? 'expression tag'        -8  32 
2 9F8S GLY B 13 ? UNP Q396C9 ? ? 'expression tag'        -7  33 
2 9F8S LEU B 14 ? UNP Q396C9 ? ? 'expression tag'        -6  34 
2 9F8S VAL B 15 ? UNP Q396C9 ? ? 'expression tag'        -5  35 
2 9F8S PRO B 16 ? UNP Q396C9 ? ? 'expression tag'        -4  36 
2 9F8S ARG B 17 ? UNP Q396C9 ? ? 'expression tag'        -3  37 
2 9F8S GLY B 18 ? UNP Q396C9 ? ? 'expression tag'        -2  38 
2 9F8S SER B 19 ? UNP Q396C9 ? ? 'expression tag'        -1  39 
2 9F8S HIS B 20 ? UNP Q396C9 ? ? 'expression tag'        0   40 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4830  ? 
1 MORE         -21   ? 
1 'SSA (A^2)'  13800 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 GLU A 32  ? HIS A 52  ? GLU A 12  HIS A 32  1 ? 21 
HELX_P HELX_P2 AA2 ARG A 54  ? LEU A 63  ? ARG A 34  LEU A 43  5 ? 10 
HELX_P HELX_P3 AA3 GLY A 86  ? PHE A 101 ? GLY A 66  PHE A 81  1 ? 16 
HELX_P HELX_P4 AA4 ASN A 163 ? LEU A 171 ? ASN A 143 LEU A 151 1 ? 9  
HELX_P HELX_P5 AA5 ASN B 33  ? THR B 53  ? ASN B 13  THR B 33  1 ? 21 
HELX_P HELX_P6 AA6 ARG B 54  ? LEU B 63  ? ARG B 34  LEU B 43  5 ? 10 
HELX_P HELX_P7 AA7 GLY B 86  ? PHE B 101 ? GLY B 66  PHE B 81  1 ? 16 
HELX_P HELX_P8 AA8 ASN B 163 ? LEU B 171 ? ASN B 143 LEU B 151 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 6 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 82  ? ARG A 85  ? ILE A 62  ARG A 65  
AA1 2 PHE A 65  ? LEU A 73  ? PHE A 45  LEU A 53  
AA1 3 LEU A 154 ? PHE A 161 ? LEU A 134 PHE A 141 
AA1 4 GLY A 138 ? GLU A 151 ? GLY A 118 GLU A 131 
AA1 5 TRP A 119 ? ILE A 130 ? TRP A 99  ILE A 110 
AA1 6 VAL A 105 ? PHE A 112 ? VAL A 85  PHE A 92  
AA2 1 ILE B 82  ? ARG B 85  ? ILE B 62  ARG B 65  
AA2 2 PHE B 65  ? LEU B 73  ? PHE B 45  LEU B 53  
AA2 3 LEU B 154 ? PHE B 161 ? LEU B 134 PHE B 141 
AA2 4 GLY B 138 ? GLU B 151 ? GLY B 118 GLU B 131 
AA2 5 TRP B 119 ? ILE B 130 ? TRP B 99  ILE B 110 
AA2 6 VAL B 105 ? PHE B 112 ? VAL B 85  PHE B 92  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ILE A 84  ? O ILE A 64  N GLY A 71  ? N GLY A 51  
AA1 2 3 N VAL A 70  ? N VAL A 50  O GLN A 158 ? O GLN A 138 
AA1 3 4 O LYS A 156 ? O LYS A 136 N ARG A 149 ? N ARG A 129 
AA1 4 5 O PHE A 144 ? O PHE A 124 N CYS A 124 ? N CYS A 104 
AA1 5 6 O TRP A 121 ? O TRP A 101 N PHE A 112 ? N PHE A 92  
AA2 1 2 O ILE B 84  ? O ILE B 64  N GLY B 71  ? N GLY B 51  
AA2 2 3 N VAL B 70  ? N VAL B 50  O GLN B 158 ? O GLN B 138 
AA2 3 4 O PHE B 161 ? O PHE B 141 N LEU B 145 ? N LEU B 125 
AA2 4 5 O TYR B 140 ? O TYR B 120 N GLY B 128 ? N GLY B 108 
AA2 5 6 O TRP B 121 ? O TRP B 101 N PHE B 112 ? N PHE B 92  
# 
_pdbx_entry_details.entry_id                   9F8S 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O 
_pdbx_validate_close_contact.auth_asym_id_1   B 
_pdbx_validate_close_contact.auth_comp_id_1   HOH 
_pdbx_validate_close_contact.auth_seq_id_1    315 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   B 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    402 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.12 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -19 ? A MET 1  
2  1 Y 1 A GLY -18 ? A GLY 2  
3  1 Y 1 A SER -17 ? A SER 3  
4  1 Y 1 A SER -16 ? A SER 4  
5  1 Y 1 A HIS -15 ? A HIS 5  
6  1 Y 1 A HIS -14 ? A HIS 6  
7  1 Y 1 A HIS -13 ? A HIS 7  
8  1 Y 1 A HIS -12 ? A HIS 8  
9  1 Y 1 A HIS -11 ? A HIS 9  
10 1 Y 1 A HIS -10 ? A HIS 10 
11 1 Y 1 A SER -9  ? A SER 11 
12 1 Y 1 A SER -8  ? A SER 12 
13 1 Y 1 A GLY -7  ? A GLY 13 
14 1 Y 1 A LEU -6  ? A LEU 14 
15 1 Y 1 A VAL -5  ? A VAL 15 
16 1 Y 1 A PRO -4  ? A PRO 16 
17 1 Y 1 A ARG -3  ? A ARG 17 
18 1 Y 1 A GLY -2  ? A GLY 18 
19 1 Y 1 A SER -1  ? A SER 19 
20 1 Y 1 A HIS 0   ? A HIS 20 
21 1 Y 1 A MET 1   ? A MET 21 
22 1 Y 1 A SER 2   ? A SER 22 
23 1 Y 1 A ASP 3   ? A ASP 23 
24 1 Y 1 A VAL 4   ? A VAL 24 
25 1 Y 1 A GLU 5   ? A GLU 25 
26 1 Y 1 A SER 6   ? A SER 26 
27 1 Y 1 A LEU 7   ? A LEU 27 
28 1 Y 1 A GLU 8   ? A GLU 28 
29 1 Y 1 A ASN 9   ? A ASN 29 
30 1 Y 1 A THR 10  ? A THR 30 
31 1 Y 1 A SER 11  ? A SER 31 
32 1 Y 1 B MET -19 ? B MET 1  
33 1 Y 1 B GLY -18 ? B GLY 2  
34 1 Y 1 B SER -17 ? B SER 3  
35 1 Y 1 B SER -16 ? B SER 4  
36 1 Y 1 B HIS -15 ? B HIS 5  
37 1 Y 1 B HIS -14 ? B HIS 6  
38 1 Y 1 B HIS -13 ? B HIS 7  
39 1 Y 1 B HIS -12 ? B HIS 8  
40 1 Y 1 B HIS -11 ? B HIS 9  
41 1 Y 1 B HIS -10 ? B HIS 10 
42 1 Y 1 B SER -9  ? B SER 11 
43 1 Y 1 B SER -8  ? B SER 12 
44 1 Y 1 B GLY -7  ? B GLY 13 
45 1 Y 1 B LEU -6  ? B LEU 14 
46 1 Y 1 B VAL -5  ? B VAL 15 
47 1 Y 1 B PRO -4  ? B PRO 16 
48 1 Y 1 B ARG -3  ? B ARG 17 
49 1 Y 1 B GLY -2  ? B GLY 18 
50 1 Y 1 B SER -1  ? B SER 19 
51 1 Y 1 B HIS 0   ? B HIS 20 
52 1 Y 1 B MET 1   ? B MET 21 
53 1 Y 1 B SER 2   ? B SER 22 
54 1 Y 1 B ASP 3   ? B ASP 23 
55 1 Y 1 B VAL 4   ? B VAL 24 
56 1 Y 1 B GLU 5   ? B GLU 25 
57 1 Y 1 B SER 6   ? B SER 26 
58 1 Y 1 B LEU 7   ? B LEU 27 
59 1 Y 1 B GLU 8   ? B GLU 28 
60 1 Y 1 B ASN 9   ? B ASN 29 
61 1 Y 1 B THR 10  ? B THR 30 
62 1 Y 1 B SER 11  ? B SER 31 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1IAM C1   C  Y N 1   
A1IAM O1   O  N N 2   
A1IAM S1   S  Y N 3   
A1IAM C2   C  Y N 4   
A1IAM O2   O  N N 5   
A1IAM C3   C  Y N 6   
A1IAM C4   C  Y N 7   
A1IAM C5   C  Y N 8   
A1IAM C6   C  Y N 9   
A1IAM C7   C  Y N 10  
A1IAM C8   C  Y N 11  
A1IAM C9   C  Y N 12  
A1IAM C10  C  Y N 13  
A1IAM C11  C  Y N 14  
A1IAM C12  C  Y N 15  
A1IAM C13  C  Y N 16  
A1IAM C14  C  Y N 17  
A1IAM C15  C  N N 18  
A1IAM C16  C  Y N 19  
A1IAM C17  C  Y N 20  
A1IAM C18  C  Y N 21  
A1IAM C19  C  Y N 22  
A1IAM C20  C  Y N 23  
A1IAM C21  C  Y N 24  
A1IAM CL1  CL N N 25  
A1IAM H1   H  N N 26  
A1IAM H13  H  N N 27  
A1IAM H2   H  N N 28  
A1IAM H3   H  N N 29  
A1IAM H4   H  N N 30  
A1IAM H5   H  N N 31  
A1IAM H6   H  N N 32  
A1IAM H7   H  N N 33  
A1IAM H8   H  N N 34  
A1IAM H9   H  N N 35  
A1IAM H10  H  N N 36  
A1IAM H11  H  N N 37  
A1IAM H12  H  N N 38  
ALA   N    N  N N 39  
ALA   CA   C  N S 40  
ALA   C    C  N N 41  
ALA   O    O  N N 42  
ALA   CB   C  N N 43  
ALA   OXT  O  N N 44  
ALA   H    H  N N 45  
ALA   H2   H  N N 46  
ALA   HA   H  N N 47  
ALA   HB1  H  N N 48  
ALA   HB2  H  N N 49  
ALA   HB3  H  N N 50  
ALA   HXT  H  N N 51  
ARG   N    N  N N 52  
ARG   CA   C  N S 53  
ARG   C    C  N N 54  
ARG   O    O  N N 55  
ARG   CB   C  N N 56  
ARG   CG   C  N N 57  
ARG   CD   C  N N 58  
ARG   NE   N  N N 59  
ARG   CZ   C  N N 60  
ARG   NH1  N  N N 61  
ARG   NH2  N  N N 62  
ARG   OXT  O  N N 63  
ARG   H    H  N N 64  
ARG   H2   H  N N 65  
ARG   HA   H  N N 66  
ARG   HB2  H  N N 67  
ARG   HB3  H  N N 68  
ARG   HG2  H  N N 69  
ARG   HG3  H  N N 70  
ARG   HD2  H  N N 71  
ARG   HD3  H  N N 72  
ARG   HE   H  N N 73  
ARG   HH11 H  N N 74  
ARG   HH12 H  N N 75  
ARG   HH21 H  N N 76  
ARG   HH22 H  N N 77  
ARG   HXT  H  N N 78  
ASN   N    N  N N 79  
ASN   CA   C  N S 80  
ASN   C    C  N N 81  
ASN   O    O  N N 82  
ASN   CB   C  N N 83  
ASN   CG   C  N N 84  
ASN   OD1  O  N N 85  
ASN   ND2  N  N N 86  
ASN   OXT  O  N N 87  
ASN   H    H  N N 88  
ASN   H2   H  N N 89  
ASN   HA   H  N N 90  
ASN   HB2  H  N N 91  
ASN   HB3  H  N N 92  
ASN   HD21 H  N N 93  
ASN   HD22 H  N N 94  
ASN   HXT  H  N N 95  
ASP   N    N  N N 96  
ASP   CA   C  N S 97  
ASP   C    C  N N 98  
ASP   O    O  N N 99  
ASP   CB   C  N N 100 
ASP   CG   C  N N 101 
ASP   OD1  O  N N 102 
ASP   OD2  O  N N 103 
ASP   OXT  O  N N 104 
ASP   H    H  N N 105 
ASP   H2   H  N N 106 
ASP   HA   H  N N 107 
ASP   HB2  H  N N 108 
ASP   HB3  H  N N 109 
ASP   HD2  H  N N 110 
ASP   HXT  H  N N 111 
CYS   N    N  N N 112 
CYS   CA   C  N R 113 
CYS   C    C  N N 114 
CYS   O    O  N N 115 
CYS   CB   C  N N 116 
CYS   SG   S  N N 117 
CYS   OXT  O  N N 118 
CYS   H    H  N N 119 
CYS   H2   H  N N 120 
CYS   HA   H  N N 121 
CYS   HB2  H  N N 122 
CYS   HB3  H  N N 123 
CYS   HG   H  N N 124 
CYS   HXT  H  N N 125 
GLN   N    N  N N 126 
GLN   CA   C  N S 127 
GLN   C    C  N N 128 
GLN   O    O  N N 129 
GLN   CB   C  N N 130 
GLN   CG   C  N N 131 
GLN   CD   C  N N 132 
GLN   OE1  O  N N 133 
GLN   NE2  N  N N 134 
GLN   OXT  O  N N 135 
GLN   H    H  N N 136 
GLN   H2   H  N N 137 
GLN   HA   H  N N 138 
GLN   HB2  H  N N 139 
GLN   HB3  H  N N 140 
GLN   HG2  H  N N 141 
GLN   HG3  H  N N 142 
GLN   HE21 H  N N 143 
GLN   HE22 H  N N 144 
GLN   HXT  H  N N 145 
GLU   N    N  N N 146 
GLU   CA   C  N S 147 
GLU   C    C  N N 148 
GLU   O    O  N N 149 
GLU   CB   C  N N 150 
GLU   CG   C  N N 151 
GLU   CD   C  N N 152 
GLU   OE1  O  N N 153 
GLU   OE2  O  N N 154 
GLU   OXT  O  N N 155 
GLU   H    H  N N 156 
GLU   H2   H  N N 157 
GLU   HA   H  N N 158 
GLU   HB2  H  N N 159 
GLU   HB3  H  N N 160 
GLU   HG2  H  N N 161 
GLU   HG3  H  N N 162 
GLU   HE2  H  N N 163 
GLU   HXT  H  N N 164 
GLY   N    N  N N 165 
GLY   CA   C  N N 166 
GLY   C    C  N N 167 
GLY   O    O  N N 168 
GLY   OXT  O  N N 169 
GLY   H    H  N N 170 
GLY   H2   H  N N 171 
GLY   HA2  H  N N 172 
GLY   HA3  H  N N 173 
GLY   HXT  H  N N 174 
GOL   C1   C  N N 175 
GOL   O1   O  N N 176 
GOL   C2   C  N N 177 
GOL   O2   O  N N 178 
GOL   C3   C  N N 179 
GOL   O3   O  N N 180 
GOL   H11  H  N N 181 
GOL   H12  H  N N 182 
GOL   HO1  H  N N 183 
GOL   H2   H  N N 184 
GOL   HO2  H  N N 185 
GOL   H31  H  N N 186 
GOL   H32  H  N N 187 
GOL   HO3  H  N N 188 
HIS   N    N  N N 189 
HIS   CA   C  N S 190 
HIS   C    C  N N 191 
HIS   O    O  N N 192 
HIS   CB   C  N N 193 
HIS   CG   C  Y N 194 
HIS   ND1  N  Y N 195 
HIS   CD2  C  Y N 196 
HIS   CE1  C  Y N 197 
HIS   NE2  N  Y N 198 
HIS   OXT  O  N N 199 
HIS   H    H  N N 200 
HIS   H2   H  N N 201 
HIS   HA   H  N N 202 
HIS   HB2  H  N N 203 
HIS   HB3  H  N N 204 
HIS   HD1  H  N N 205 
HIS   HD2  H  N N 206 
HIS   HE1  H  N N 207 
HIS   HE2  H  N N 208 
HIS   HXT  H  N N 209 
HOH   O    O  N N 210 
HOH   H1   H  N N 211 
HOH   H2   H  N N 212 
ILE   N    N  N N 213 
ILE   CA   C  N S 214 
ILE   C    C  N N 215 
ILE   O    O  N N 216 
ILE   CB   C  N S 217 
ILE   CG1  C  N N 218 
ILE   CG2  C  N N 219 
ILE   CD1  C  N N 220 
ILE   OXT  O  N N 221 
ILE   H    H  N N 222 
ILE   H2   H  N N 223 
ILE   HA   H  N N 224 
ILE   HB   H  N N 225 
ILE   HG12 H  N N 226 
ILE   HG13 H  N N 227 
ILE   HG21 H  N N 228 
ILE   HG22 H  N N 229 
ILE   HG23 H  N N 230 
ILE   HD11 H  N N 231 
ILE   HD12 H  N N 232 
ILE   HD13 H  N N 233 
ILE   HXT  H  N N 234 
LEU   N    N  N N 235 
LEU   CA   C  N S 236 
LEU   C    C  N N 237 
LEU   O    O  N N 238 
LEU   CB   C  N N 239 
LEU   CG   C  N N 240 
LEU   CD1  C  N N 241 
LEU   CD2  C  N N 242 
LEU   OXT  O  N N 243 
LEU   H    H  N N 244 
LEU   H2   H  N N 245 
LEU   HA   H  N N 246 
LEU   HB2  H  N N 247 
LEU   HB3  H  N N 248 
LEU   HG   H  N N 249 
LEU   HD11 H  N N 250 
LEU   HD12 H  N N 251 
LEU   HD13 H  N N 252 
LEU   HD21 H  N N 253 
LEU   HD22 H  N N 254 
LEU   HD23 H  N N 255 
LEU   HXT  H  N N 256 
LYS   N    N  N N 257 
LYS   CA   C  N S 258 
LYS   C    C  N N 259 
LYS   O    O  N N 260 
LYS   CB   C  N N 261 
LYS   CG   C  N N 262 
LYS   CD   C  N N 263 
LYS   CE   C  N N 264 
LYS   NZ   N  N N 265 
LYS   OXT  O  N N 266 
LYS   H    H  N N 267 
LYS   H2   H  N N 268 
LYS   HA   H  N N 269 
LYS   HB2  H  N N 270 
LYS   HB3  H  N N 271 
LYS   HG2  H  N N 272 
LYS   HG3  H  N N 273 
LYS   HD2  H  N N 274 
LYS   HD3  H  N N 275 
LYS   HE2  H  N N 276 
LYS   HE3  H  N N 277 
LYS   HZ1  H  N N 278 
LYS   HZ2  H  N N 279 
LYS   HZ3  H  N N 280 
LYS   HXT  H  N N 281 
MET   N    N  N N 282 
MET   CA   C  N S 283 
MET   C    C  N N 284 
MET   O    O  N N 285 
MET   CB   C  N N 286 
MET   CG   C  N N 287 
MET   SD   S  N N 288 
MET   CE   C  N N 289 
MET   OXT  O  N N 290 
MET   H    H  N N 291 
MET   H2   H  N N 292 
MET   HA   H  N N 293 
MET   HB2  H  N N 294 
MET   HB3  H  N N 295 
MET   HG2  H  N N 296 
MET   HG3  H  N N 297 
MET   HE1  H  N N 298 
MET   HE2  H  N N 299 
MET   HE3  H  N N 300 
MET   HXT  H  N N 301 
PHE   N    N  N N 302 
PHE   CA   C  N S 303 
PHE   C    C  N N 304 
PHE   O    O  N N 305 
PHE   CB   C  N N 306 
PHE   CG   C  Y N 307 
PHE   CD1  C  Y N 308 
PHE   CD2  C  Y N 309 
PHE   CE1  C  Y N 310 
PHE   CE2  C  Y N 311 
PHE   CZ   C  Y N 312 
PHE   OXT  O  N N 313 
PHE   H    H  N N 314 
PHE   H2   H  N N 315 
PHE   HA   H  N N 316 
PHE   HB2  H  N N 317 
PHE   HB3  H  N N 318 
PHE   HD1  H  N N 319 
PHE   HD2  H  N N 320 
PHE   HE1  H  N N 321 
PHE   HE2  H  N N 322 
PHE   HZ   H  N N 323 
PHE   HXT  H  N N 324 
PRO   N    N  N N 325 
PRO   CA   C  N S 326 
PRO   C    C  N N 327 
PRO   O    O  N N 328 
PRO   CB   C  N N 329 
PRO   CG   C  N N 330 
PRO   CD   C  N N 331 
PRO   OXT  O  N N 332 
PRO   H    H  N N 333 
PRO   HA   H  N N 334 
PRO   HB2  H  N N 335 
PRO   HB3  H  N N 336 
PRO   HG2  H  N N 337 
PRO   HG3  H  N N 338 
PRO   HD2  H  N N 339 
PRO   HD3  H  N N 340 
PRO   HXT  H  N N 341 
SER   N    N  N N 342 
SER   CA   C  N S 343 
SER   C    C  N N 344 
SER   O    O  N N 345 
SER   CB   C  N N 346 
SER   OG   O  N N 347 
SER   OXT  O  N N 348 
SER   H    H  N N 349 
SER   H2   H  N N 350 
SER   HA   H  N N 351 
SER   HB2  H  N N 352 
SER   HB3  H  N N 353 
SER   HG   H  N N 354 
SER   HXT  H  N N 355 
THR   N    N  N N 356 
THR   CA   C  N S 357 
THR   C    C  N N 358 
THR   O    O  N N 359 
THR   CB   C  N R 360 
THR   OG1  O  N N 361 
THR   CG2  C  N N 362 
THR   OXT  O  N N 363 
THR   H    H  N N 364 
THR   H2   H  N N 365 
THR   HA   H  N N 366 
THR   HB   H  N N 367 
THR   HG1  H  N N 368 
THR   HG21 H  N N 369 
THR   HG22 H  N N 370 
THR   HG23 H  N N 371 
THR   HXT  H  N N 372 
TRP   N    N  N N 373 
TRP   CA   C  N S 374 
TRP   C    C  N N 375 
TRP   O    O  N N 376 
TRP   CB   C  N N 377 
TRP   CG   C  Y N 378 
TRP   CD1  C  Y N 379 
TRP   CD2  C  Y N 380 
TRP   NE1  N  Y N 381 
TRP   CE2  C  Y N 382 
TRP   CE3  C  Y N 383 
TRP   CZ2  C  Y N 384 
TRP   CZ3  C  Y N 385 
TRP   CH2  C  Y N 386 
TRP   OXT  O  N N 387 
TRP   H    H  N N 388 
TRP   H2   H  N N 389 
TRP   HA   H  N N 390 
TRP   HB2  H  N N 391 
TRP   HB3  H  N N 392 
TRP   HD1  H  N N 393 
TRP   HE1  H  N N 394 
TRP   HE3  H  N N 395 
TRP   HZ2  H  N N 396 
TRP   HZ3  H  N N 397 
TRP   HH2  H  N N 398 
TRP   HXT  H  N N 399 
TYR   N    N  N N 400 
TYR   CA   C  N S 401 
TYR   C    C  N N 402 
TYR   O    O  N N 403 
TYR   CB   C  N N 404 
TYR   CG   C  Y N 405 
TYR   CD1  C  Y N 406 
TYR   CD2  C  Y N 407 
TYR   CE1  C  Y N 408 
TYR   CE2  C  Y N 409 
TYR   CZ   C  Y N 410 
TYR   OH   O  N N 411 
TYR   OXT  O  N N 412 
TYR   H    H  N N 413 
TYR   H2   H  N N 414 
TYR   HA   H  N N 415 
TYR   HB2  H  N N 416 
TYR   HB3  H  N N 417 
TYR   HD1  H  N N 418 
TYR   HD2  H  N N 419 
TYR   HE1  H  N N 420 
TYR   HE2  H  N N 421 
TYR   HH   H  N N 422 
TYR   HXT  H  N N 423 
VAL   N    N  N N 424 
VAL   CA   C  N S 425 
VAL   C    C  N N 426 
VAL   O    O  N N 427 
VAL   CB   C  N N 428 
VAL   CG1  C  N N 429 
VAL   CG2  C  N N 430 
VAL   OXT  O  N N 431 
VAL   H    H  N N 432 
VAL   H2   H  N N 433 
VAL   HA   H  N N 434 
VAL   HB   H  N N 435 
VAL   HG11 H  N N 436 
VAL   HG12 H  N N 437 
VAL   HG13 H  N N 438 
VAL   HG21 H  N N 439 
VAL   HG22 H  N N 440 
VAL   HG23 H  N N 441 
VAL   HXT  H  N N 442 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1IAM CL1 C19  sing N N 1   
A1IAM C19 C20  doub Y N 2   
A1IAM C19 C18  sing Y N 3   
A1IAM C20 C21  sing Y N 4   
A1IAM C18 C17  doub Y N 5   
A1IAM C12 C11  doub Y N 6   
A1IAM C12 C13  sing Y N 7   
A1IAM C11 C10  sing Y N 8   
A1IAM C21 C16  doub Y N 9   
A1IAM C13 C14  doub Y N 10  
A1IAM C17 C16  sing Y N 11  
A1IAM C16 C15  sing N N 12  
A1IAM C10 C9   doub Y N 13  
A1IAM C14 C9   sing Y N 14  
A1IAM C9  C8   sing N N 15  
A1IAM C15 O1   doub N N 16  
A1IAM C15 C7   sing N N 17  
A1IAM C8  C7   doub Y N 18  
A1IAM C8  S1   sing Y N 19  
A1IAM C7  C5   sing Y N 20  
A1IAM S1  C6   sing Y N 21  
A1IAM C5  C4   doub Y N 22  
A1IAM C5  C6   sing Y N 23  
A1IAM C4  C3   sing Y N 24  
A1IAM C6  C1   doub Y N 25  
A1IAM C3  C2   doub Y N 26  
A1IAM C1  C2   sing Y N 27  
A1IAM C2  O2   sing N N 28  
A1IAM C1  H1   sing N N 29  
A1IAM O2  H13  sing N N 30  
A1IAM C3  H2   sing N N 31  
A1IAM C4  H3   sing N N 32  
A1IAM C10 H4   sing N N 33  
A1IAM C11 H5   sing N N 34  
A1IAM C12 H6   sing N N 35  
A1IAM C13 H7   sing N N 36  
A1IAM C14 H8   sing N N 37  
A1IAM C17 H9   sing N N 38  
A1IAM C18 H10  sing N N 39  
A1IAM C20 H11  sing N N 40  
A1IAM C21 H12  sing N N 41  
ALA   N   CA   sing N N 42  
ALA   N   H    sing N N 43  
ALA   N   H2   sing N N 44  
ALA   CA  C    sing N N 45  
ALA   CA  CB   sing N N 46  
ALA   CA  HA   sing N N 47  
ALA   C   O    doub N N 48  
ALA   C   OXT  sing N N 49  
ALA   CB  HB1  sing N N 50  
ALA   CB  HB2  sing N N 51  
ALA   CB  HB3  sing N N 52  
ALA   OXT HXT  sing N N 53  
ARG   N   CA   sing N N 54  
ARG   N   H    sing N N 55  
ARG   N   H2   sing N N 56  
ARG   CA  C    sing N N 57  
ARG   CA  CB   sing N N 58  
ARG   CA  HA   sing N N 59  
ARG   C   O    doub N N 60  
ARG   C   OXT  sing N N 61  
ARG   CB  CG   sing N N 62  
ARG   CB  HB2  sing N N 63  
ARG   CB  HB3  sing N N 64  
ARG   CG  CD   sing N N 65  
ARG   CG  HG2  sing N N 66  
ARG   CG  HG3  sing N N 67  
ARG   CD  NE   sing N N 68  
ARG   CD  HD2  sing N N 69  
ARG   CD  HD3  sing N N 70  
ARG   NE  CZ   sing N N 71  
ARG   NE  HE   sing N N 72  
ARG   CZ  NH1  sing N N 73  
ARG   CZ  NH2  doub N N 74  
ARG   NH1 HH11 sing N N 75  
ARG   NH1 HH12 sing N N 76  
ARG   NH2 HH21 sing N N 77  
ARG   NH2 HH22 sing N N 78  
ARG   OXT HXT  sing N N 79  
ASN   N   CA   sing N N 80  
ASN   N   H    sing N N 81  
ASN   N   H2   sing N N 82  
ASN   CA  C    sing N N 83  
ASN   CA  CB   sing N N 84  
ASN   CA  HA   sing N N 85  
ASN   C   O    doub N N 86  
ASN   C   OXT  sing N N 87  
ASN   CB  CG   sing N N 88  
ASN   CB  HB2  sing N N 89  
ASN   CB  HB3  sing N N 90  
ASN   CG  OD1  doub N N 91  
ASN   CG  ND2  sing N N 92  
ASN   ND2 HD21 sing N N 93  
ASN   ND2 HD22 sing N N 94  
ASN   OXT HXT  sing N N 95  
ASP   N   CA   sing N N 96  
ASP   N   H    sing N N 97  
ASP   N   H2   sing N N 98  
ASP   CA  C    sing N N 99  
ASP   CA  CB   sing N N 100 
ASP   CA  HA   sing N N 101 
ASP   C   O    doub N N 102 
ASP   C   OXT  sing N N 103 
ASP   CB  CG   sing N N 104 
ASP   CB  HB2  sing N N 105 
ASP   CB  HB3  sing N N 106 
ASP   CG  OD1  doub N N 107 
ASP   CG  OD2  sing N N 108 
ASP   OD2 HD2  sing N N 109 
ASP   OXT HXT  sing N N 110 
CYS   N   CA   sing N N 111 
CYS   N   H    sing N N 112 
CYS   N   H2   sing N N 113 
CYS   CA  C    sing N N 114 
CYS   CA  CB   sing N N 115 
CYS   CA  HA   sing N N 116 
CYS   C   O    doub N N 117 
CYS   C   OXT  sing N N 118 
CYS   CB  SG   sing N N 119 
CYS   CB  HB2  sing N N 120 
CYS   CB  HB3  sing N N 121 
CYS   SG  HG   sing N N 122 
CYS   OXT HXT  sing N N 123 
GLN   N   CA   sing N N 124 
GLN   N   H    sing N N 125 
GLN   N   H2   sing N N 126 
GLN   CA  C    sing N N 127 
GLN   CA  CB   sing N N 128 
GLN   CA  HA   sing N N 129 
GLN   C   O    doub N N 130 
GLN   C   OXT  sing N N 131 
GLN   CB  CG   sing N N 132 
GLN   CB  HB2  sing N N 133 
GLN   CB  HB3  sing N N 134 
GLN   CG  CD   sing N N 135 
GLN   CG  HG2  sing N N 136 
GLN   CG  HG3  sing N N 137 
GLN   CD  OE1  doub N N 138 
GLN   CD  NE2  sing N N 139 
GLN   NE2 HE21 sing N N 140 
GLN   NE2 HE22 sing N N 141 
GLN   OXT HXT  sing N N 142 
GLU   N   CA   sing N N 143 
GLU   N   H    sing N N 144 
GLU   N   H2   sing N N 145 
GLU   CA  C    sing N N 146 
GLU   CA  CB   sing N N 147 
GLU   CA  HA   sing N N 148 
GLU   C   O    doub N N 149 
GLU   C   OXT  sing N N 150 
GLU   CB  CG   sing N N 151 
GLU   CB  HB2  sing N N 152 
GLU   CB  HB3  sing N N 153 
GLU   CG  CD   sing N N 154 
GLU   CG  HG2  sing N N 155 
GLU   CG  HG3  sing N N 156 
GLU   CD  OE1  doub N N 157 
GLU   CD  OE2  sing N N 158 
GLU   OE2 HE2  sing N N 159 
GLU   OXT HXT  sing N N 160 
GLY   N   CA   sing N N 161 
GLY   N   H    sing N N 162 
GLY   N   H2   sing N N 163 
GLY   CA  C    sing N N 164 
GLY   CA  HA2  sing N N 165 
GLY   CA  HA3  sing N N 166 
GLY   C   O    doub N N 167 
GLY   C   OXT  sing N N 168 
GLY   OXT HXT  sing N N 169 
GOL   C1  O1   sing N N 170 
GOL   C1  C2   sing N N 171 
GOL   C1  H11  sing N N 172 
GOL   C1  H12  sing N N 173 
GOL   O1  HO1  sing N N 174 
GOL   C2  O2   sing N N 175 
GOL   C2  C3   sing N N 176 
GOL   C2  H2   sing N N 177 
GOL   O2  HO2  sing N N 178 
GOL   C3  O3   sing N N 179 
GOL   C3  H31  sing N N 180 
GOL   C3  H32  sing N N 181 
GOL   O3  HO3  sing N N 182 
HIS   N   CA   sing N N 183 
HIS   N   H    sing N N 184 
HIS   N   H2   sing N N 185 
HIS   CA  C    sing N N 186 
HIS   CA  CB   sing N N 187 
HIS   CA  HA   sing N N 188 
HIS   C   O    doub N N 189 
HIS   C   OXT  sing N N 190 
HIS   CB  CG   sing N N 191 
HIS   CB  HB2  sing N N 192 
HIS   CB  HB3  sing N N 193 
HIS   CG  ND1  sing Y N 194 
HIS   CG  CD2  doub Y N 195 
HIS   ND1 CE1  doub Y N 196 
HIS   ND1 HD1  sing N N 197 
HIS   CD2 NE2  sing Y N 198 
HIS   CD2 HD2  sing N N 199 
HIS   CE1 NE2  sing Y N 200 
HIS   CE1 HE1  sing N N 201 
HIS   NE2 HE2  sing N N 202 
HIS   OXT HXT  sing N N 203 
HOH   O   H1   sing N N 204 
HOH   O   H2   sing N N 205 
ILE   N   CA   sing N N 206 
ILE   N   H    sing N N 207 
ILE   N   H2   sing N N 208 
ILE   CA  C    sing N N 209 
ILE   CA  CB   sing N N 210 
ILE   CA  HA   sing N N 211 
ILE   C   O    doub N N 212 
ILE   C   OXT  sing N N 213 
ILE   CB  CG1  sing N N 214 
ILE   CB  CG2  sing N N 215 
ILE   CB  HB   sing N N 216 
ILE   CG1 CD1  sing N N 217 
ILE   CG1 HG12 sing N N 218 
ILE   CG1 HG13 sing N N 219 
ILE   CG2 HG21 sing N N 220 
ILE   CG2 HG22 sing N N 221 
ILE   CG2 HG23 sing N N 222 
ILE   CD1 HD11 sing N N 223 
ILE   CD1 HD12 sing N N 224 
ILE   CD1 HD13 sing N N 225 
ILE   OXT HXT  sing N N 226 
LEU   N   CA   sing N N 227 
LEU   N   H    sing N N 228 
LEU   N   H2   sing N N 229 
LEU   CA  C    sing N N 230 
LEU   CA  CB   sing N N 231 
LEU   CA  HA   sing N N 232 
LEU   C   O    doub N N 233 
LEU   C   OXT  sing N N 234 
LEU   CB  CG   sing N N 235 
LEU   CB  HB2  sing N N 236 
LEU   CB  HB3  sing N N 237 
LEU   CG  CD1  sing N N 238 
LEU   CG  CD2  sing N N 239 
LEU   CG  HG   sing N N 240 
LEU   CD1 HD11 sing N N 241 
LEU   CD1 HD12 sing N N 242 
LEU   CD1 HD13 sing N N 243 
LEU   CD2 HD21 sing N N 244 
LEU   CD2 HD22 sing N N 245 
LEU   CD2 HD23 sing N N 246 
LEU   OXT HXT  sing N N 247 
LYS   N   CA   sing N N 248 
LYS   N   H    sing N N 249 
LYS   N   H2   sing N N 250 
LYS   CA  C    sing N N 251 
LYS   CA  CB   sing N N 252 
LYS   CA  HA   sing N N 253 
LYS   C   O    doub N N 254 
LYS   C   OXT  sing N N 255 
LYS   CB  CG   sing N N 256 
LYS   CB  HB2  sing N N 257 
LYS   CB  HB3  sing N N 258 
LYS   CG  CD   sing N N 259 
LYS   CG  HG2  sing N N 260 
LYS   CG  HG3  sing N N 261 
LYS   CD  CE   sing N N 262 
LYS   CD  HD2  sing N N 263 
LYS   CD  HD3  sing N N 264 
LYS   CE  NZ   sing N N 265 
LYS   CE  HE2  sing N N 266 
LYS   CE  HE3  sing N N 267 
LYS   NZ  HZ1  sing N N 268 
LYS   NZ  HZ2  sing N N 269 
LYS   NZ  HZ3  sing N N 270 
LYS   OXT HXT  sing N N 271 
MET   N   CA   sing N N 272 
MET   N   H    sing N N 273 
MET   N   H2   sing N N 274 
MET   CA  C    sing N N 275 
MET   CA  CB   sing N N 276 
MET   CA  HA   sing N N 277 
MET   C   O    doub N N 278 
MET   C   OXT  sing N N 279 
MET   CB  CG   sing N N 280 
MET   CB  HB2  sing N N 281 
MET   CB  HB3  sing N N 282 
MET   CG  SD   sing N N 283 
MET   CG  HG2  sing N N 284 
MET   CG  HG3  sing N N 285 
MET   SD  CE   sing N N 286 
MET   CE  HE1  sing N N 287 
MET   CE  HE2  sing N N 288 
MET   CE  HE3  sing N N 289 
MET   OXT HXT  sing N N 290 
PHE   N   CA   sing N N 291 
PHE   N   H    sing N N 292 
PHE   N   H2   sing N N 293 
PHE   CA  C    sing N N 294 
PHE   CA  CB   sing N N 295 
PHE   CA  HA   sing N N 296 
PHE   C   O    doub N N 297 
PHE   C   OXT  sing N N 298 
PHE   CB  CG   sing N N 299 
PHE   CB  HB2  sing N N 300 
PHE   CB  HB3  sing N N 301 
PHE   CG  CD1  doub Y N 302 
PHE   CG  CD2  sing Y N 303 
PHE   CD1 CE1  sing Y N 304 
PHE   CD1 HD1  sing N N 305 
PHE   CD2 CE2  doub Y N 306 
PHE   CD2 HD2  sing N N 307 
PHE   CE1 CZ   doub Y N 308 
PHE   CE1 HE1  sing N N 309 
PHE   CE2 CZ   sing Y N 310 
PHE   CE2 HE2  sing N N 311 
PHE   CZ  HZ   sing N N 312 
PHE   OXT HXT  sing N N 313 
PRO   N   CA   sing N N 314 
PRO   N   CD   sing N N 315 
PRO   N   H    sing N N 316 
PRO   CA  C    sing N N 317 
PRO   CA  CB   sing N N 318 
PRO   CA  HA   sing N N 319 
PRO   C   O    doub N N 320 
PRO   C   OXT  sing N N 321 
PRO   CB  CG   sing N N 322 
PRO   CB  HB2  sing N N 323 
PRO   CB  HB3  sing N N 324 
PRO   CG  CD   sing N N 325 
PRO   CG  HG2  sing N N 326 
PRO   CG  HG3  sing N N 327 
PRO   CD  HD2  sing N N 328 
PRO   CD  HD3  sing N N 329 
PRO   OXT HXT  sing N N 330 
SER   N   CA   sing N N 331 
SER   N   H    sing N N 332 
SER   N   H2   sing N N 333 
SER   CA  C    sing N N 334 
SER   CA  CB   sing N N 335 
SER   CA  HA   sing N N 336 
SER   C   O    doub N N 337 
SER   C   OXT  sing N N 338 
SER   CB  OG   sing N N 339 
SER   CB  HB2  sing N N 340 
SER   CB  HB3  sing N N 341 
SER   OG  HG   sing N N 342 
SER   OXT HXT  sing N N 343 
THR   N   CA   sing N N 344 
THR   N   H    sing N N 345 
THR   N   H2   sing N N 346 
THR   CA  C    sing N N 347 
THR   CA  CB   sing N N 348 
THR   CA  HA   sing N N 349 
THR   C   O    doub N N 350 
THR   C   OXT  sing N N 351 
THR   CB  OG1  sing N N 352 
THR   CB  CG2  sing N N 353 
THR   CB  HB   sing N N 354 
THR   OG1 HG1  sing N N 355 
THR   CG2 HG21 sing N N 356 
THR   CG2 HG22 sing N N 357 
THR   CG2 HG23 sing N N 358 
THR   OXT HXT  sing N N 359 
TRP   N   CA   sing N N 360 
TRP   N   H    sing N N 361 
TRP   N   H2   sing N N 362 
TRP   CA  C    sing N N 363 
TRP   CA  CB   sing N N 364 
TRP   CA  HA   sing N N 365 
TRP   C   O    doub N N 366 
TRP   C   OXT  sing N N 367 
TRP   CB  CG   sing N N 368 
TRP   CB  HB2  sing N N 369 
TRP   CB  HB3  sing N N 370 
TRP   CG  CD1  doub Y N 371 
TRP   CG  CD2  sing Y N 372 
TRP   CD1 NE1  sing Y N 373 
TRP   CD1 HD1  sing N N 374 
TRP   CD2 CE2  doub Y N 375 
TRP   CD2 CE3  sing Y N 376 
TRP   NE1 CE2  sing Y N 377 
TRP   NE1 HE1  sing N N 378 
TRP   CE2 CZ2  sing Y N 379 
TRP   CE3 CZ3  doub Y N 380 
TRP   CE3 HE3  sing N N 381 
TRP   CZ2 CH2  doub Y N 382 
TRP   CZ2 HZ2  sing N N 383 
TRP   CZ3 CH2  sing Y N 384 
TRP   CZ3 HZ3  sing N N 385 
TRP   CH2 HH2  sing N N 386 
TRP   OXT HXT  sing N N 387 
TYR   N   CA   sing N N 388 
TYR   N   H    sing N N 389 
TYR   N   H2   sing N N 390 
TYR   CA  C    sing N N 391 
TYR   CA  CB   sing N N 392 
TYR   CA  HA   sing N N 393 
TYR   C   O    doub N N 394 
TYR   C   OXT  sing N N 395 
TYR   CB  CG   sing N N 396 
TYR   CB  HB2  sing N N 397 
TYR   CB  HB3  sing N N 398 
TYR   CG  CD1  doub Y N 399 
TYR   CG  CD2  sing Y N 400 
TYR   CD1 CE1  sing Y N 401 
TYR   CD1 HD1  sing N N 402 
TYR   CD2 CE2  doub Y N 403 
TYR   CD2 HD2  sing N N 404 
TYR   CE1 CZ   doub Y N 405 
TYR   CE1 HE1  sing N N 406 
TYR   CE2 CZ   sing Y N 407 
TYR   CE2 HE2  sing N N 408 
TYR   CZ  OH   sing N N 409 
TYR   OH  HH   sing N N 410 
TYR   OXT HXT  sing N N 411 
VAL   N   CA   sing N N 412 
VAL   N   H    sing N N 413 
VAL   N   H2   sing N N 414 
VAL   CA  C    sing N N 415 
VAL   CA  CB   sing N N 416 
VAL   CA  HA   sing N N 417 
VAL   C   O    doub N N 418 
VAL   C   OXT  sing N N 419 
VAL   CB  CG1  sing N N 420 
VAL   CB  CG2  sing N N 421 
VAL   CB  HB   sing N N 422 
VAL   CG1 HG11 sing N N 423 
VAL   CG1 HG12 sing N N 424 
VAL   CG1 HG13 sing N N 425 
VAL   CG2 HG21 sing N N 426 
VAL   CG2 HG22 sing N N 427 
VAL   CG2 HG23 sing N N 428 
VAL   OXT HXT  sing N N 429 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3B4O 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9F8S 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018512 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003368 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014514 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.018794 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CL 
H  
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    . GLU   A 1 32  ? -16.921 24.571 -2.607 1.00 41.06 ? 12  GLU   A N    1 
ATOM   2    C  CA   . GLU   A 1 32  ? -16.121 24.765 -1.402 1.00 45.53 ? 12  GLU   A CA   1 
ATOM   3    C  C    . GLU   A 1 32  ? -16.103 23.472 -0.598 1.00 50.63 ? 12  GLU   A C    1 
ATOM   4    O  O    . GLU   A 1 32  ? -15.059 23.051 -0.098 1.00 45.78 ? 12  GLU   A O    1 
ATOM   5    C  CB   . GLU   A 1 32  ? -16.671 25.915 -0.563 1.00 58.19 ? 12  GLU   A CB   1 
ATOM   6    H  HA   . GLU   A 1 32  ? -15.209 24.980 -1.653 1.00 54.66 ? 12  GLU   A HA   1 
ATOM   7    N  N    . ASN   A 1 33  ? -17.271 22.836 -0.478 0.97 47.18 ? 13  ASN   A N    1 
ATOM   8    C  CA   . ASN   A 1 33  ? -17.343 21.586 0.270  0.97 56.29 ? 13  ASN   A CA   1 
ATOM   9    C  C    . ASN   A 1 33  ? -16.478 20.513 -0.378 0.97 53.51 ? 13  ASN   A C    1 
ATOM   10   O  O    . ASN   A 1 33  ? -15.852 19.706 0.319  0.97 44.53 ? 13  ASN   A O    1 
ATOM   11   C  CB   . ASN   A 1 33  ? -18.792 21.111 0.376  0.97 39.54 ? 13  ASN   A CB   1 
ATOM   12   H  H    . ASN   A 1 33  ? -18.017 23.102 -0.812 0.97 56.64 ? 13  ASN   A H    1 
ATOM   13   H  HA   . ASN   A 1 33  ? -17.010 21.736 1.169  0.97 67.56 ? 13  ASN   A HA   1 
ATOM   14   N  N    . ARG   A 1 34  ? -16.424 20.492 -1.712 1.00 42.95 ? 14  ARG   A N    1 
ATOM   15   C  CA   . ARG   A 1 34  ? -15.608 19.496 -2.399 1.00 43.27 ? 14  ARG   A CA   1 
ATOM   16   C  C    . ARG   A 1 34  ? -14.125 19.703 -2.113 1.00 33.15 ? 14  ARG   A C    1 
ATOM   17   O  O    . ARG   A 1 34  ? -13.373 18.732 -1.975 1.00 34.49 ? 14  ARG   A O    1 
ATOM   18   C  CB   . ARG   A 1 34  ? -15.877 19.545 -3.903 1.00 44.62 ? 14  ARG   A CB   1 
ATOM   19   H  H    . ARG   A 1 34  ? -16.843 21.034 -2.232 1.00 51.56 ? 14  ARG   A H    1 
ATOM   20   H  HA   . ARG   A 1 34  ? -15.853 18.613 -2.080 1.00 51.94 ? 14  ARG   A HA   1 
ATOM   21   N  N    . ALA   A 1 35  ? -13.686 20.959 -2.017 1.00 27.85 ? 15  ALA   A N    1 
ATOM   22   C  CA   . ALA   A 1 35  ? -12.291 21.228 -1.689 1.00 29.83 ? 15  ALA   A CA   1 
ATOM   23   C  C    . ALA   A 1 35  ? -11.988 20.876 -0.237 1.00 31.26 ? 15  ALA   A C    1 
ATOM   24   O  O    . ALA   A 1 35  ? -10.885 20.413 0.082  1.00 24.14 ? 15  ALA   A O    1 
ATOM   25   C  CB   . ALA   A 1 35  ? -11.961 22.696 -1.961 1.00 30.51 ? 15  ALA   A CB   1 
ATOM   26   H  H    . ALA   A 1 35  ? -14.169 21.661 -2.135 1.00 33.44 ? 15  ALA   A H    1 
ATOM   27   H  HA   . ALA   A 1 35  ? -11.724 20.682 -2.252 1.00 35.81 ? 15  ALA   A HA   1 
ATOM   28   H  HB1  . ALA   A 1 35  ? -11.031 22.857 -1.738 1.00 36.63 ? 15  ALA   A HB1  1 
ATOM   29   H  HB2  . ALA   A 1 35  ? -12.114 22.885 -2.900 1.00 36.63 ? 15  ALA   A HB2  1 
ATOM   30   H  HB3  . ALA   A 1 35  ? -12.534 23.255 -1.413 1.00 36.63 ? 15  ALA   A HB3  1 
ATOM   31   N  N    . GLN   A 1 36  ? -12.948 21.091 0.662  1.00 27.18 ? 16  GLN   A N    1 
ATOM   32   C  CA   . GLN   A 1 36  ? -12.699 20.772 2.062  1.00 23.29 ? 16  GLN   A CA   1 
ATOM   33   C  C    . GLN   A 1 36  ? -12.658 19.267 2.278  1.00 21.91 ? 16  GLN   A C    1 
ATOM   34   O  O    . GLN   A 1 36  ? -11.816 18.764 3.029  1.00 25.96 ? 16  GLN   A O    1 
ATOM   35   C  CB   . GLN   A 1 36  ? -13.764 21.417 2.945  1.00 29.29 ? 16  GLN   A CB   1 
ATOM   36   C  CG   . GLN   A 1 36  ? -13.672 22.931 2.980  1.00 45.32 ? 16  GLN   A CG   1 
ATOM   37   C  CD   . GLN   A 1 36  ? -14.542 23.548 4.053  1.00 60.77 ? 16  GLN   A CD   1 
ATOM   38   O  OE1  . GLN   A 1 36  ? -14.827 22.924 5.074  1.00 60.02 ? 16  GLN   A OE1  1 
ATOM   39   N  NE2  . GLN   A 1 36  ? -14.973 24.784 3.825  1.00 62.84 ? 16  GLN   A NE2  1 
ATOM   40   H  H    . GLN   A 1 36  ? -13.728 21.411 0.493  1.00 32.63 ? 16  GLN   A H    1 
ATOM   41   H  HA   . GLN   A 1 36  ? -11.837 21.135 2.320  1.00 27.96 ? 16  GLN   A HA   1 
ATOM   42   H  HB2  . GLN   A 1 36  ? -14.641 21.179 2.606  1.00 35.17 ? 16  GLN   A HB2  1 
ATOM   43   H  HB3  . GLN   A 1 36  ? -13.660 21.090 3.852  1.00 35.17 ? 16  GLN   A HB3  1 
ATOM   44   H  HG2  . GLN   A 1 36  ? -12.753 23.187 3.155  1.00 54.40 ? 16  GLN   A HG2  1 
ATOM   45   H  HG3  . GLN   A 1 36  ? -13.957 23.285 2.123  1.00 54.40 ? 16  GLN   A HG3  1 
ATOM   46   H  HE21 . GLN   A 1 36  ? -14.753 25.189 3.099  1.00 75.42 ? 16  GLN   A HE21 1 
ATOM   47   H  HE22 . GLN   A 1 36  ? -15.471 25.179 4.404  1.00 75.42 ? 16  GLN   A HE22 1 
ATOM   48   N  N    . VAL   A 1 37  ? -13.559 18.533 1.622  1.00 21.72 ? 17  VAL   A N    1 
ATOM   49   C  CA   . VAL   A 1 37  ? -13.558 17.080 1.742  1.00 23.59 ? 17  VAL   A CA   1 
ATOM   50   C  C    . VAL   A 1 37  ? -12.254 16.507 1.208  1.00 25.25 ? 17  VAL   A C    1 
ATOM   51   O  O    . VAL   A 1 37  ? -11.648 15.621 1.823  1.00 30.26 ? 17  VAL   A O    1 
ATOM   52   C  CB   . VAL   A 1 37  ? -14.774 16.483 1.011  1.00 38.55 ? 17  VAL   A CB   1 
ATOM   53   C  CG1  . VAL   A 1 37  ? -14.606 14.979 0.846  1.00 42.39 ? 17  VAL   A CG1  1 
ATOM   54   C  CG2  . VAL   A 1 37  ? -16.050 16.815 1.764  1.00 36.83 ? 17  VAL   A CG2  1 
ATOM   55   H  H    . VAL   A 1 37  ? -14.172 18.850 1.109  1.00 26.09 ? 17  VAL   A H    1 
ATOM   56   H  HA   . VAL   A 1 37  ? -13.627 16.842 2.680  1.00 28.33 ? 17  VAL   A HA   1 
ATOM   57   H  HB   . VAL   A 1 37  ? -14.836 16.877 0.127  1.00 46.28 ? 17  VAL   A HB   1 
ATOM   58   H  HG11 . VAL   A 1 37  ? -15.474 14.585 0.665  1.00 50.89 ? 17  VAL   A HG11 1 
ATOM   59   H  HG12 . VAL   A 1 37  ? -14.005 14.804 0.105  1.00 50.89 ? 17  VAL   A HG12 1 
ATOM   60   H  HG13 . VAL   A 1 37  ? -14.242 14.610 1.666  1.00 50.89 ? 17  VAL   A HG13 1 
ATOM   61   H  HG21 . VAL   A 1 37  ? -16.808 16.468 1.268  1.00 44.21 ? 17  VAL   A HG21 1 
ATOM   62   H  HG22 . VAL   A 1 37  ? -16.013 16.405 2.643  1.00 44.21 ? 17  VAL   A HG22 1 
ATOM   63   H  HG23 . VAL   A 1 37  ? -16.124 17.778 1.851  1.00 44.21 ? 17  VAL   A HG23 1 
ATOM   64   N  N    . ALA   A 1 38  ? -11.804 17.003 0.051  1.00 23.52 ? 18  ALA   A N    1 
ATOM   65   C  CA   . ALA   A 1 38  ? -10.548 16.531 -0.522 1.00 25.91 ? 18  ALA   A CA   1 
ATOM   66   C  C    . ALA   A 1 38  ? -9.378  16.799 0.412  1.00 21.51 ? 18  ALA   A C    1 
ATOM   67   O  O    . ALA   A 1 38  ? -8.510  15.937 0.596  1.00 20.82 ? 18  ALA   A O    1 
ATOM   68   C  CB   . ALA   A 1 38  ? -10.304 17.200 -1.873 1.00 27.17 ? 18  ALA   A CB   1 
ATOM   69   H  H    . ALA   A 1 38  ? -12.204 17.606 -0.414 1.00 28.25 ? 18  ALA   A H    1 
ATOM   70   H  HA   . ALA   A 1 38  ? -10.605 15.573 -0.666 1.00 31.11 ? 18  ALA   A HA   1 
ATOM   71   H  HB1  . ALA   A 1 38  ? -9.466  16.875 -2.239 1.00 32.62 ? 18  ALA   A HB1  1 
ATOM   72   H  HB2  . ALA   A 1 38  ? -11.035 16.978 -2.471 1.00 32.62 ? 18  ALA   A HB2  1 
ATOM   73   H  HB3  . ALA   A 1 38  ? -10.260 18.161 -1.746 1.00 32.62 ? 18  ALA   A HB3  1 
ATOM   74   N  N    . ALA   A 1 39  ? -9.322  17.999 0.991  1.00 20.04 ? 19  ALA   A N    1 
ATOM   75   C  CA   . ALA   A 1 39  ? -8.246  18.307 1.926  1.00 22.53 ? 19  ALA   A CA   1 
ATOM   76   C  C    . ALA   A 1 39  ? -8.272  17.359 3.119  1.00 20.82 ? 19  ALA   A C    1 
ATOM   77   O  O    . ALA   A 1 39  ? -7.236  16.823 3.526  1.00 19.79 ? 19  ALA   A O    1 
ATOM   78   C  CB   . ALA   A 1 39  ? -8.348  19.762 2.386  1.00 23.99 ? 19  ALA   A CB   1 
ATOM   79   H  H    . ALA   A 1 39  ? -9.883  18.638 0.862  1.00 24.06 ? 19  ALA   A H    1 
ATOM   80   H  HA   . ALA   A 1 39  ? -7.395  18.195 1.474  1.00 27.06 ? 19  ALA   A HA   1 
ATOM   81   H  HB1  . ALA   A 1 39  ? -7.626  19.948 3.006  1.00 28.81 ? 19  ALA   A HB1  1 
ATOM   82   H  HB2  . ALA   A 1 39  ? -8.278  20.343 1.612  1.00 28.81 ? 19  ALA   A HB2  1 
ATOM   83   H  HB3  . ALA   A 1 39  ? -9.203  19.895 2.824  1.00 28.81 ? 19  ALA   A HB3  1 
ATOM   84   N  N    . ARG   A 1 40  ? -9.451  17.136 3.700  1.00 19.65 ? 20  ARG   A N    1 
ATOM   85   C  CA   . ARG   A 1 40  ? -9.508  16.295 4.892  1.00 19.66 ? 20  ARG   A CA   1 
ATOM   86   C  C    . ARG   A 1 40  ? -9.076  14.866 4.577  1.00 17.10 ? 20  ARG   A C    1 
ATOM   87   O  O    . ARG   A 1 40  ? -8.371  14.234 5.373  1.00 20.69 ? 20  ARG   A O    1 
ATOM   88   C  CB   . ARG   A 1 40  ? -10.912 16.319 5.488  1.00 20.05 ? 20  ARG   A CB   1 
ATOM   89   C  CG   . ARG   A 1 40  ? -11.038 15.529 6.769  1.00 22.58 ? 20  ARG   A CG   1 
ATOM   90   C  CD   . ARG   A 1 40  ? -12.465 15.579 7.307  1.00 21.87 ? 20  ARG   A CD   1 
ATOM   91   N  NE   . ARG   A 1 40  ? -12.803 16.888 7.858  1.00 20.55 ? 20  ARG   A NE   1 
ATOM   92   C  CZ   . ARG   A 1 40  ? -13.586 17.783 7.271  1.00 26.22 ? 20  ARG   A CZ   1 
ATOM   93   N  NH1  . ARG   A 1 40  ? -14.158 17.545 6.101  1.00 24.24 ? 20  ARG   A NH1  1 
ATOM   94   N  NH2  . ARG   A 1 40  ? -13.809 18.944 7.878  1.00 18.75 ? 20  ARG   A NH2  1 
ATOM   95   H  H    . ARG   A 1 40  ? -10.207 17.448 3.434  1.00 23.60 ? 20  ARG   A H    1 
ATOM   96   H  HA   . ARG   A 1 40  ? -8.897  16.651 5.556  1.00 23.61 ? 20  ARG   A HA   1 
ATOM   97   H  HB2  . ARG   A 1 40  ? -11.155 17.238 5.680  1.00 24.07 ? 20  ARG   A HB2  1 
ATOM   98   H  HB3  . ARG   A 1 40  ? -11.532 15.942 4.844  1.00 24.07 ? 20  ARG   A HB3  1 
ATOM   99   H  HG2  . ARG   A 1 40  ? -10.811 14.601 6.602  1.00 27.11 ? 20  ARG   A HG2  1 
ATOM   100  H  HG3  . ARG   A 1 40  ? -10.446 15.906 7.439  1.00 27.11 ? 20  ARG   A HG3  1 
ATOM   101  H  HD2  . ARG   A 1 40  ? -13.081 15.361 6.593  1.00 26.26 ? 20  ARG   A HD2  1 
ATOM   102  H  HD3  . ARG   A 1 40  ? -12.551 14.928 8.020  1.00 26.26 ? 20  ARG   A HD3  1 
ATOM   103  H  HE   . ARG   A 1 40  ? -12.468 17.095 8.623  1.00 24.67 ? 20  ARG   A HE   1 
ATOM   104  H  HH11 . ARG   A 1 40  ? -14.027 16.801 5.693  1.00 29.10 ? 20  ARG   A HH11 1 
ATOM   105  H  HH12 . ARG   A 1 40  ? -14.662 18.143 5.744  1.00 29.10 ? 20  ARG   A HH12 1 
ATOM   106  H  HH21 . ARG   A 1 40  ? -13.444 19.108 8.639  1.00 22.52 ? 20  ARG   A HH21 1 
ATOM   107  H  HH22 . ARG   A 1 40  ? -14.316 19.532 7.509  1.00 22.52 ? 20  ARG   A HH22 1 
ATOM   108  N  N    . GLN   A 1 41  ? -9.488  14.340 3.420  0.84 17.39 ? 21  GLN   A N    1 
ATOM   109  C  CA   . GLN   A 1 41  ? -9.115  12.974 3.066  0.84 16.91 ? 21  GLN   A CA   1 
ATOM   110  C  C    . GLN   A 1 41  ? -7.610  12.853 2.872  0.84 16.81 ? 21  GLN   A C    1 
ATOM   111  O  O    . GLN   A 1 41  ? -6.997  11.862 3.294  0.84 17.02 ? 21  GLN   A O    1 
ATOM   112  C  CB   . GLN   A 1 41  ? -9.843  12.535 1.799  0.84 20.86 ? 21  GLN   A CB   1 
ATOM   113  C  CG   . GLN   A 1 41  ? -11.347 12.396 1.952  0.84 37.86 ? 21  GLN   A CG   1 
ATOM   114  C  CD   . GLN   A 1 41  ? -12.046 12.120 0.628  0.84 50.19 ? 21  GLN   A CD   1 
ATOM   115  O  OE1  . GLN   A 1 41  ? -11.858 12.845 -0.350 0.84 47.05 ? 21  GLN   A OE1  1 
ATOM   116  N  NE2  . GLN   A 1 41  ? -12.851 11.064 0.591  0.84 62.95 ? 21  GLN   A NE2  1 
ATOM   117  H  H    . GLN   A 1 41  ? -9.973  14.745 2.837  0.84 20.88 ? 21  GLN   A H    1 
ATOM   118  H  HA   . GLN   A 1 41  ? -9.375  12.377 3.785  0.84 20.31 ? 21  GLN   A HA   1 
ATOM   119  H  HB2  . GLN   A 1 41  ? -9.678  13.191 1.103  0.84 25.06 ? 21  GLN   A HB2  1 
ATOM   120  H  HB3  . GLN   A 1 41  ? -9.494  11.672 1.524  0.84 25.06 ? 21  GLN   A HB3  1 
ATOM   121  H  HG2  . GLN   A 1 41  ? -11.537 11.657 2.551  0.84 45.45 ? 21  GLN   A HG2  1 
ATOM   122  H  HG3  . GLN   A 1 41  ? -11.707 13.220 2.317  0.84 45.45 ? 21  GLN   A HG3  1 
ATOM   123  H  HE21 . GLN   A 1 41  ? -12.957 10.579 1.293  0.84 75.56 ? 21  GLN   A HE21 1 
ATOM   124  H  HE22 . GLN   A 1 41  ? -13.268 10.867 -0.135 0.84 75.56 ? 21  GLN   A HE22 1 
ATOM   125  N  N    . HIS   A 1 42  ? -7.000  13.849 2.230  1.00 17.52 ? 22  HIS   A N    1 
ATOM   126  C  CA   . HIS   A 1 42  ? -5.561  13.810 2.042  1.00 14.59 ? 22  HIS   A CA   1 
ATOM   127  C  C    . HIS   A 1 42  ? -4.829  13.976 3.364  1.00 14.29 ? 22  HIS   A C    1 
ATOM   128  O  O    . HIS   A 1 42  ? -3.889  13.233 3.672  1.00 16.92 ? 22  HIS   A O    1 
ATOM   129  C  CB   . HIS   A 1 42  ? -5.116  14.908 1.094  1.00 18.02 ? 22  HIS   A CB   1 
ATOM   130  C  CG   . HIS   A 1 42  ? -3.641  15.126 1.117  1.00 19.85 ? 22  HIS   A CG   1 
ATOM   131  N  ND1  . HIS   A 1 42  ? -2.766  14.307 0.440  1.00 21.22 ? 22  HIS   A ND1  1 
ATOM   132  C  CD2  . HIS   A 1 42  ? -2.881  16.033 1.773  1.00 19.69 ? 22  HIS   A CD2  1 
ATOM   133  C  CE1  . HIS   A 1 42  ? -1.530  14.717 0.656  1.00 18.17 ? 22  HIS   A CE1  1 
ATOM   134  N  NE2  . HIS   A 1 42  ? -1.572  15.768 1.455  1.00 21.72 ? 22  HIS   A NE2  1 
ATOM   135  H  H    . HIS   A 1 42  ? -7.390  14.542 1.902  1.00 21.04 ? 22  HIS   A H    1 
ATOM   136  H  HA   . HIS   A 1 42  ? -5.310  12.955 1.659  1.00 17.52 ? 22  HIS   A HA   1 
ATOM   137  H  HB2  . HIS   A 1 42  ? -5.370  14.667 0.189  1.00 21.64 ? 22  HIS   A HB2  1 
ATOM   138  H  HB3  . HIS   A 1 42  ? -5.546  15.739 1.349  1.00 21.64 ? 22  HIS   A HB3  1 
ATOM   139  H  HD2  . HIS   A 1 42  ? -3.189  16.722 2.317  1.00 23.65 ? 22  HIS   A HD2  1 
ATOM   140  H  HE1  . HIS   A 1 42  ? -0.760  14.335 0.300  1.00 21.83 ? 22  HIS   A HE1  1 
ATOM   141  H  HE2  . HIS   A 1 42  ? -0.890  16.207 1.740  1.00 26.08 ? 22  HIS   A HE2  1 
ATOM   142  N  N    . ASN   A 1 43  ? -5.229  14.978 4.147  1.00 17.05 ? 23  ASN   A N    1 
ATOM   143  C  CA   . ASN   A 1 43  ? -4.554  15.234 5.410  1.00 18.59 ? 23  ASN   A CA   1 
ATOM   144  C  C    . ASN   A 1 43  ? -4.640  14.024 6.329  1.00 20.14 ? 23  ASN   A C    1 
ATOM   145  O  O    . ASN   A 1 43  ? -3.681  13.707 7.038  1.00 17.73 ? 23  ASN   A O    1 
ATOM   146  C  CB   . ASN   A 1 43  ? -5.149  16.472 6.079  1.00 16.94 ? 23  ASN   A CB   1 
ATOM   147  C  CG   . ASN   A 1 43  ? -4.902  17.753 5.287  1.00 16.48 ? 23  ASN   A CG   1 
ATOM   148  O  OD1  . ASN   A 1 43  ? -4.006  17.824 4.440  1.00 16.66 ? 23  ASN   A OD1  1 
ATOM   149  N  ND2  . ASN   A 1 43  ? -5.693  18.780 5.579  1.00 18.13 ? 23  ASN   A ND2  1 
ATOM   150  H  H    . ASN   A 1 43  ? -5.878  15.514 3.971  1.00 20.48 ? 23  ASN   A H    1 
ATOM   151  H  HA   . ASN   A 1 43  ? -3.616  15.410 5.236  1.00 22.32 ? 23  ASN   A HA   1 
ATOM   152  H  HB2  . ASN   A 1 43  ? -6.108  16.354 6.165  1.00 20.35 ? 23  ASN   A HB2  1 
ATOM   153  H  HB3  . ASN   A 1 43  ? -4.748  16.580 6.956  1.00 20.35 ? 23  ASN   A HB3  1 
ATOM   154  H  HD21 . ASN   A 1 43  ? -5.598  19.528 5.165  1.00 21.77 ? 23  ASN   A HD21 1 
ATOM   155  H  HD22 . ASN   A 1 43  ? -6.305  18.695 6.177  1.00 21.77 ? 23  ASN   A HD22 1 
ATOM   156  N  N    . ARG   A 1 44  ? -5.775  13.322 6.324  1.00 16.97 ? 24  ARG   A N    1 
ATOM   157  C  CA   . ARG   A 1 44  ? -5.882  12.137 7.168  1.00 15.77 ? 24  ARG   A CA   1 
ATOM   158  C  C    . ARG   A 1 44  ? -4.810  11.110 6.805  1.00 20.15 ? 24  ARG   A C    1 
ATOM   159  O  O    . ARG   A 1 44  ? -4.239  10.462 7.691  1.00 17.14 ? 24  ARG   A O    1 
ATOM   160  C  CB   . ARG   A 1 44  ? -7.267  11.515 7.052  1.00 18.13 ? 24  ARG   A CB   1 
ATOM   161  C  CG   . ARG   A 1 44  ? -7.387  10.270 7.884  1.00 24.43 ? 24  ARG   A CG   1 
ATOM   162  C  CD   . ARG   A 1 44  ? -8.788  9.716  7.880  1.00 37.07 ? 24  ARG   A CD   1 
ATOM   163  N  NE   . ARG   A 1 44  ? -8.820  8.473  8.636  1.00 49.07 ? 24  ARG   A NE   1 
ATOM   164  C  CZ   . ARG   A 1 44  ? -9.481  8.296  9.770  1.00 29.18 ? 24  ARG   A CZ   1 
ATOM   165  N  NH1  . ARG   A 1 44  ? -10.264 9.239  10.270 1.00 43.37 ? 24  ARG   A NH1  1 
ATOM   166  N  NH2  . ARG   A 1 44  ? -9.365  7.136  10.411 1.00 33.04 ? 24  ARG   A NH2  1 
ATOM   167  H  H    . ARG   A 1 44  ? -6.474  13.504 5.857  1.00 20.38 ? 24  ARG   A H    1 
ATOM   168  H  HA   . ARG   A 1 44  ? -5.747  12.396 8.093  1.00 18.94 ? 24  ARG   A HA   1 
ATOM   169  H  HB2  . ARG   A 1 44  ? -7.930  12.152 7.361  1.00 21.78 ? 24  ARG   A HB2  1 
ATOM   170  H  HB3  . ARG   A 1 44  ? -7.435  11.279 6.126  1.00 21.78 ? 24  ARG   A HB3  1 
ATOM   171  H  HG2  . ARG   A 1 44  ? -6.801  9.584  7.529  1.00 29.33 ? 24  ARG   A HG2  1 
ATOM   172  H  HG3  . ARG   A 1 44  ? -7.145  10.475 8.801  1.00 29.33 ? 24  ARG   A HG3  1 
ATOM   173  H  HD2  . ARG   A 1 44  ? -9.390  10.365 8.271  1.00 44.50 ? 24  ARG   A HD2  1 
ATOM   174  H  HD3  . ARG   A 1 44  ? -9.051  9.522  6.967  1.00 44.50 ? 24  ARG   A HD3  1 
ATOM   175  H  HE   . ARG   A 1 44  ? -8.378  7.805  8.324  1.00 58.90 ? 24  ARG   A HE   1 
ATOM   176  H  HH11 . ARG   A 1 44  ? -10.352 9.994  9.873  1.00 52.06 ? 24  ARG   A HH11 1 
ATOM   177  H  HH12 . ARG   A 1 44  ? -10.684 9.095  11.006 1.00 52.06 ? 24  ARG   A HH12 1 
ATOM   178  H  HH21 . ARG   A 1 44  ? -8.862  6.516  10.091 1.00 39.67 ? 24  ARG   A HH21 1 
ATOM   179  H  HH22 . ARG   A 1 44  ? -9.794  7.005  11.145 1.00 39.67 ? 24  ARG   A HH22 1 
ATOM   180  N  N    . LYS   A 1 45  ? -4.535  10.937 5.508  1.00 16.78 ? 25  LYS   A N    1 
ATOM   181  C  CA   . LYS   A 1 45  ? -3.493  10.002 5.092  1.00 16.15 ? 25  LYS   A CA   1 
ATOM   182  C  C    . LYS   A 1 45  ? -2.130  10.401 5.651  1.00 16.03 ? 25  LYS   A C    1 
ATOM   183  O  O    . LYS   A 1 45  ? -1.332  9.536  6.033  1.00 16.36 ? 25  LYS   A O    1 
ATOM   184  C  CB   . LYS   A 1 45  ? -3.437  9.912  3.568  1.00 20.90 ? 25  LYS   A CB   1 
ATOM   185  C  CG   . LYS   A 1 45  ? -4.694  9.347  2.926  1.00 28.56 ? 25  LYS   A CG   1 
ATOM   186  H  H    . LYS   A 1 45  ? -4.932  11.343 4.862  1.00 20.15 ? 25  LYS   A H    1 
ATOM   187  H  HA   . LYS   A 1 45  ? -3.708  9.120  5.434  1.00 19.40 ? 25  LYS   A HA   1 
ATOM   188  H  HB2  . LYS   A 1 45  ? -3.298  10.802 3.209  1.00 25.10 ? 25  LYS   A HB2  1 
ATOM   189  H  HB3  . LYS   A 1 45  ? -2.695  9.339  3.318  1.00 25.10 ? 25  LYS   A HB3  1 
ATOM   190  N  N    . ILE   A 1 46  ? -1.843  11.705 5.703  1.00 17.43 ? 26  ILE   A N    1 
ATOM   191  C  CA   . ILE   A 1 46  ? -0.570  12.167 6.252  1.00 15.61 ? 26  ILE   A CA   1 
ATOM   192  C  C    . ILE   A 1 46  ? -0.500  11.886 7.751  1.00 15.73 ? 26  ILE   A C    1 
ATOM   193  O  O    . ILE   A 1 46  ? 0.551   11.503 8.276  1.00 14.27 ? 26  ILE   A O    1 
ATOM   194  C  CB   . ILE   A 1 46  ? -0.382  13.665 5.958  1.00 12.70 ? 26  ILE   A CB   1 
ATOM   195  C  CG1  . ILE   A 1 46  ? -0.351  13.940 4.455  1.00 14.59 ? 26  ILE   A CG1  1 
ATOM   196  C  CG2  . ILE   A 1 46  ? 0.886   14.207 6.609  1.00 14.62 ? 26  ILE   A CG2  1 
ATOM   197  C  CD1  . ILE   A 1 46  ? 0.836   13.324 3.719  1.00 22.43 ? 26  ILE   A CD1  1 
ATOM   198  H  H    . ILE   A 1 46  ? -2.363  12.333 5.430  1.00 20.94 ? 26  ILE   A H    1 
ATOM   199  H  HA   . ILE   A 1 46  ? 0.153   11.681 5.826  1.00 18.75 ? 26  ILE   A HA   1 
ATOM   200  H  HB   . ILE   A 1 46  ? -1.139  14.141 6.334  1.00 15.26 ? 26  ILE   A HB   1 
ATOM   201  H  HG12 . ILE   A 1 46  ? -1.161  13.585 4.056  1.00 17.52 ? 26  ILE   A HG12 1 
ATOM   202  H  HG13 . ILE   A 1 46  ? -0.315  14.900 4.317  1.00 17.52 ? 26  ILE   A HG13 1 
ATOM   203  H  HG21 . ILE   A 1 46  ? 1.090   15.074 6.225  1.00 17.57 ? 26  ILE   A HG21 1 
ATOM   204  H  HG22 . ILE   A 1 46  ? 0.740   14.296 7.564  1.00 17.57 ? 26  ILE   A HG22 1 
ATOM   205  H  HG23 . ILE   A 1 46  ? 1.616   13.591 6.440  1.00 17.57 ? 26  ILE   A HG23 1 
ATOM   206  H  HD11 . ILE   A 1 46  ? 0.770   13.550 2.779  1.00 26.94 ? 26  ILE   A HD11 1 
ATOM   207  H  HD12 . ILE   A 1 46  ? 1.660   13.681 4.086  1.00 26.94 ? 26  ILE   A HD12 1 
ATOM   208  H  HD13 . ILE   A 1 46  ? 0.814   12.361 3.827  1.00 26.94 ? 26  ILE   A HD13 1 
ATOM   209  N  N    . VAL   A 1 47  ? -1.610  12.086 8.468  1.00 16.34 ? 27  VAL   A N    1 
ATOM   210  C  CA   . VAL   A 1 47  ? -1.625  11.780 9.896  1.00 12.12 ? 27  VAL   A CA   1 
ATOM   211  C  C    . VAL   A 1 47  ? -1.364  10.298 10.116 1.00 14.18 ? 27  VAL   A C    1 
ATOM   212  O  O    . VAL   A 1 47  ? -0.572  9.906  10.985 1.00 14.43 ? 27  VAL   A O    1 
ATOM   213  C  CB   . VAL   A 1 47  ? -2.963  12.203 10.529 1.00 10.97 ? 27  VAL   A CB   1 
ATOM   214  C  CG1  . VAL   A 1 47  ? -3.035  11.734 11.976 1.00 14.86 ? 27  VAL   A CG1  1 
ATOM   215  C  CG2  . VAL   A 1 47  ? -3.126  13.699 10.428 1.00 15.71 ? 27  VAL   A CG2  1 
ATOM   216  H  H    . VAL   A 1 47  ? -2.351  12.391 8.157  1.00 19.63 ? 27  VAL   A H    1 
ATOM   217  H  HA   . VAL   A 1 47  ? -0.916  12.277 10.333 1.00 14.57 ? 27  VAL   A HA   1 
ATOM   218  H  HB   . VAL   A 1 47  ? -3.691  11.787 10.041 1.00 13.18 ? 27  VAL   A HB   1 
ATOM   219  H  HG11 . VAL   A 1 47  ? -3.736  12.226 12.431 1.00 17.85 ? 27  VAL   A HG11 1 
ATOM   220  H  HG12 . VAL   A 1 47  ? -3.234  10.785 11.994 1.00 17.85 ? 27  VAL   A HG12 1 
ATOM   221  H  HG13 . VAL   A 1 47  ? -2.182  11.904 12.406 1.00 17.85 ? 27  VAL   A HG13 1 
ATOM   222  H  HG21 . VAL   A 1 47  ? -3.957  13.955 10.857 1.00 18.86 ? 27  VAL   A HG21 1 
ATOM   223  H  HG22 . VAL   A 1 47  ? -2.378  14.128 10.872 1.00 18.86 ? 27  VAL   A HG22 1 
ATOM   224  H  HG23 . VAL   A 1 47  ? -3.145  13.953 9.492  1.00 18.86 ? 27  VAL   A HG23 1 
ATOM   225  N  N    . GLU   A 1 48  ? -2.043  9.450  9.336  1.00 13.89 ? 28  GLU   A N    1 
ATOM   226  C  CA   . GLU   A 1 48  ? -1.821  8.014  9.440  1.00 15.48 ? 28  GLU   A CA   1 
ATOM   227  C  C    . GLU   A 1 48  ? -0.364  7.679  9.168  1.00 14.97 ? 28  GLU   A C    1 
ATOM   228  O  O    . GLU   A 1 48  ? 0.247   6.882  9.889  1.00 16.46 ? 28  GLU   A O    1 
ATOM   229  C  CB   . GLU   A 1 48  ? -2.733  7.266  8.465  1.00 16.61 ? 28  GLU   A CB   1 
ATOM   230  C  CG   . GLU   A 1 48  ? -4.201  7.326  8.835  1.00 25.38 ? 28  GLU   A CG   1 
ATOM   231  C  CD   . GLU   A 1 48  ? -5.113  6.793  7.743  1.00 41.34 ? 28  GLU   A CD   1 
ATOM   232  O  OE1  . GLU   A 1 48  ? -4.600  6.423  6.664  1.00 52.50 ? 28  GLU   A OE1  1 
ATOM   233  O  OE2  . GLU   A 1 48  ? -6.343  6.748  7.967  1.00 56.21 ? 28  GLU   A OE2  1 
ATOM   234  H  H    . GLU   A 1 48  ? -2.628  9.681  8.749  1.00 16.69 ? 28  GLU   A H    1 
ATOM   235  H  HA   . GLU   A 1 48  ? -2.036  7.723  10.340 1.00 18.59 ? 28  GLU   A HA   1 
ATOM   236  H  HB2  . GLU   A 1 48  ? -2.633  7.656  7.582  1.00 19.96 ? 28  GLU   A HB2  1 
ATOM   237  H  HB3  . GLU   A 1 48  ? -2.470  6.333  8.444  1.00 19.96 ? 28  GLU   A HB3  1 
ATOM   238  H  HG2  . GLU   A 1 48  ? -4.347  6.793  9.632  1.00 30.48 ? 28  GLU   A HG2  1 
ATOM   239  H  HG3  . GLU   A 1 48  ? -4.446  8.249  9.005  1.00 30.48 ? 28  GLU   A HG3  1 
ATOM   240  N  N    . GLN   A 1 49  ? 0.215   8.289  8.131  1.00 16.54 ? 29  GLN   A N    1 
ATOM   241  C  CA   . GLN   A 1 49  ? 1.608   8.019  7.809  1.00 15.96 ? 29  GLN   A CA   1 
ATOM   242  C  C    . GLN   A 1 49  ? 2.522   8.450  8.949  1.00 15.11 ? 29  GLN   A C    1 
ATOM   243  O  O    . GLN   A 1 49  ? 3.447   7.726  9.333  1.00 17.65 ? 29  GLN   A O    1 
ATOM   244  C  CB   . GLN   A 1 49  ? 2.007   8.726  6.517  1.00 17.86 ? 29  GLN   A CB   1 
ATOM   245  C  CG   . GLN   A 1 49  ? 3.417   8.360  6.113  0.69 21.12 ? 29  GLN   A CG   1 
ATOM   246  C  CD   . GLN   A 1 49  ? 3.850   8.946  4.792  0.48 27.43 ? 29  GLN   A CD   1 
ATOM   247  O  OE1  . GLN   A 1 49  ? 3.033   9.428  4.003  1.00 29.74 ? 29  GLN   A OE1  1 
ATOM   248  N  NE2  . GLN   A 1 49  ? 5.151   8.902  4.540  0.93 33.34 ? 29  GLN   A NE2  1 
ATOM   249  H  H    . GLN   A 1 49  ? -0.173  8.853  7.610  1.00 19.86 ? 29  GLN   A H    1 
ATOM   250  H  HA   . GLN   A 1 49  ? 1.723   7.065  7.677  1.00 19.17 ? 29  GLN   A HA   1 
ATOM   251  H  HB2  . GLN   A 1 49  ? 1.406   8.458  5.805  1.00 21.45 ? 29  GLN   A HB2  1 
ATOM   252  H  HB3  . GLN   A 1 49  ? 1.967   9.686  6.650  1.00 21.45 ? 29  GLN   A HB3  1 
ATOM   253  H  HG2  . GLN   A 1 49  ? 4.034   8.682  6.789  0.69 25.36 ? 29  GLN   A HG2  1 
ATOM   254  H  HG3  . GLN   A 1 49  ? 3.481   7.395  6.044  0.70 25.36 ? 29  GLN   A HG3  1 
ATOM   255  H  HE21 . GLN   A 1 49  ? 5.689   8.557  5.115  0.92 40.02 ? 29  GLN   A HE21 1 
ATOM   256  H  HE22 . GLN   A 1 49  ? 5.457   9.221  3.802  0.89 40.02 ? 29  GLN   A HE22 1 
ATOM   257  N  N    . TYR   A 1 50  ? 2.285   9.645  9.491  1.00 15.35 ? 30  TYR   A N    1 
ATOM   258  C  CA   . TYR   A 1 50  ? 3.088   10.123 10.610 1.00 12.96 ? 30  TYR   A CA   1 
ATOM   259  C  C    . TYR   A 1 50  ? 3.021   9.159  11.788 1.00 14.62 ? 30  TYR   A C    1 
ATOM   260  O  O    . TYR   A 1 50  ? 4.053   8.750  12.331 1.00 16.51 ? 30  TYR   A O    1 
ATOM   261  C  CB   . TYR   A 1 50  ? 2.610   11.512 11.027 1.00 13.69 ? 30  TYR   A CB   1 
ATOM   262  C  CG   . TYR   A 1 50  ? 3.420   12.151 12.124 1.00 13.04 ? 30  TYR   A CG   1 
ATOM   263  C  CD1  . TYR   A 1 50  ? 3.300   11.727 13.442 1.00 14.48 ? 30  TYR   A CD1  1 
ATOM   264  C  CD2  . TYR   A 1 50  ? 4.296   13.190 11.848 1.00 13.82 ? 30  TYR   A CD2  1 
ATOM   265  C  CE1  . TYR   A 1 50  ? 4.036   12.315 14.455 1.00 14.05 ? 30  TYR   A CE1  1 
ATOM   266  C  CE2  . TYR   A 1 50  ? 5.033   13.788 12.854 1.00 16.42 ? 30  TYR   A CE2  1 
ATOM   267  C  CZ   . TYR   A 1 50  ? 4.906   13.348 14.150 1.00 18.01 ? 30  TYR   A CZ   1 
ATOM   268  O  OH   . TYR   A 1 50  ? 5.659   13.959 15.129 1.00 16.62 ? 30  TYR   A OH   1 
ATOM   269  H  H    . TYR   A 1 50  ? 1.673   10.190 9.231  1.00 18.44 ? 30  TYR   A H    1 
ATOM   270  H  HA   . TYR   A 1 50  ? 4.014   10.194 10.330 1.00 15.57 ? 30  TYR   A HA   1 
ATOM   271  H  HB2  . TYR   A 1 50  ? 2.648   12.098 10.255 1.00 16.45 ? 30  TYR   A HB2  1 
ATOM   272  H  HB3  . TYR   A 1 50  ? 1.694   11.444 11.340 1.00 16.45 ? 30  TYR   A HB3  1 
ATOM   273  H  HD1  . TYR   A 1 50  ? 2.716   11.032 13.646 1.00 17.39 ? 30  TYR   A HD1  1 
ATOM   274  H  HD2  . TYR   A 1 50  ? 4.387   13.491 10.973 1.00 16.60 ? 30  TYR   A HD2  1 
ATOM   275  H  HE1  . TYR   A 1 50  ? 3.949   12.018 15.332 1.00 16.88 ? 30  TYR   A HE1  1 
ATOM   276  H  HE2  . TYR   A 1 50  ? 5.620   14.480 12.653 1.00 19.73 ? 30  TYR   A HE2  1 
ATOM   277  H  HH   . TYR   A 1 50  ? 5.497   13.610 15.876 1.00 19.96 ? 30  TYR   A HH   1 
ATOM   278  N  N    . MET   A 1 51  ? 1.810   8.798  12.214 1.00 13.07 ? 31  MET   A N    1 
ATOM   279  C  CA   . MET   A 1 51  ? 1.675   7.969  13.401 1.00 15.09 ? 31  MET   A CA   1 
ATOM   280  C  C    . MET   A 1 51  ? 2.246   6.572  13.210 1.00 17.52 ? 31  MET   A C    1 
ATOM   281  O  O    . MET   A 1 51  ? 2.595   5.924  14.199 1.00 17.86 ? 31  MET   A O    1 
ATOM   282  C  CB   . MET   A 1 51  ? 0.204   7.849  13.815 1.00 14.33 ? 31  MET   A CB   1 
ATOM   283  C  CG   . MET   A 1 51  ? -0.483  9.163  14.130 1.00 16.30 ? 31  MET   A CG   1 
ATOM   284  S  SD   . MET   A 1 51  ? 0.338   10.109 15.424 1.00 14.92 ? 31  MET   A SD   1 
ATOM   285  C  CE   . MET   A 1 51  ? 0.413   8.889  16.739 1.00 14.32 ? 31  MET   A CE   1 
ATOM   286  H  H    . MET   A 1 51  ? 1.067   9.017  11.839 1.00 15.70 ? 31  MET   A H    1 
ATOM   287  H  HA   . MET   A 1 51  ? 2.152   8.396  14.129 1.00 18.13 ? 31  MET   A HA   1 
ATOM   288  H  HB2  . MET   A 1 51  ? -0.285  7.435  13.086 1.00 17.21 ? 31  MET   A HB2  1 
ATOM   289  H  HB3  . MET   A 1 51  ? 0.146   7.285  14.601 1.00 17.21 ? 31  MET   A HB3  1 
ATOM   290  H  HG2  . MET   A 1 51  ? -0.500  9.710  13.331 1.00 19.57 ? 31  MET   A HG2  1 
ATOM   291  H  HG3  . MET   A 1 51  ? -1.389  8.981  14.424 1.00 19.57 ? 31  MET   A HG3  1 
ATOM   292  H  HE1  . MET   A 1 51  ? 0.756   9.317  17.539 1.00 17.20 ? 31  MET   A HE1  1 
ATOM   293  H  HE2  . MET   A 1 51  ? -0.479  8.544  16.902 1.00 17.20 ? 31  MET   A HE2  1 
ATOM   294  H  HE3  . MET   A 1 51  ? 1.004   8.169  16.471 1.00 17.20 ? 31  MET   A HE3  1 
ATOM   295  N  N    . HIS   A 1 52  ? 2.339   6.085  11.978 1.00 17.03 ? 32  HIS   A N    1 
ATOM   296  C  CA   . HIS   A 1 52  ? 2.883   4.759  11.728 1.00 16.49 ? 32  HIS   A CA   1 
ATOM   297  C  C    . HIS   A 1 52  ? 4.347   4.792  11.315 1.00 19.52 ? 32  HIS   A C    1 
ATOM   298  O  O    . HIS   A 1 52  ? 4.909   3.743  10.981 1.00 20.66 ? 32  HIS   A O    1 
ATOM   299  C  CB   . HIS   A 1 52  ? 2.030   4.043  10.684 1.00 18.79 ? 32  HIS   A CB   1 
ATOM   300  C  CG   . HIS   A 1 52  ? 0.676   3.659  11.195 1.00 19.80 ? 32  HIS   A CG   1 
ATOM   301  N  ND1  . HIS   A 1 52  ? -0.477  4.313  10.818 1.00 32.74 ? 32  HIS   A ND1  1 
ATOM   302  C  CD2  . HIS   A 1 52  ? 0.300   2.725  12.100 1.00 25.06 ? 32  HIS   A CD2  1 
ATOM   303  C  CE1  . HIS   A 1 52  ? -1.509  3.776  11.444 1.00 25.86 ? 32  HIS   A CE1  1 
ATOM   304  N  NE2  . HIS   A 1 52  ? -1.065  2.815  12.233 1.00 25.75 ? 32  HIS   A NE2  1 
ATOM   305  H  H    . HIS   A 1 52  ? 2.093   6.504  11.269 1.00 20.46 ? 32  HIS   A H    1 
ATOM   306  H  HA   . HIS   A 1 52  ? 2.827   4.242  12.546 1.00 19.81 ? 32  HIS   A HA   1 
ATOM   307  H  HB2  . HIS   A 1 52  ? 1.906   4.630  9.922  1.00 22.56 ? 32  HIS   A HB2  1 
ATOM   308  H  HB3  . HIS   A 1 52  ? 2.486   3.233  10.407 1.00 22.56 ? 32  HIS   A HB3  1 
ATOM   309  H  HD1  . HIS   A 1 52  ? -0.520  4.958  10.251 1.00 39.31 ? 32  HIS   A HD1  1 
ATOM   310  H  HD2  . HIS   A 1 52  ? 0.856   2.128  12.543 1.00 30.09 ? 32  HIS   A HD2  1 
ATOM   311  H  HE1  . HIS   A 1 52  ? -2.396  4.037  11.350 1.00 31.05 ? 32  HIS   A HE1  1 
ATOM   312  N  N    . THR   A 1 53  ? 4.993   5.954  11.377 1.00 19.21 ? 33  THR   A N    1 
ATOM   313  C  CA   . THR   A 1 53  ? 6.399   6.052  11.009 1.00 17.99 ? 33  THR   A CA   1 
ATOM   314  C  C    . THR   A 1 53  ? 7.255   5.494  12.139 1.00 20.46 ? 33  THR   A C    1 
ATOM   315  O  O    . THR   A 1 53  ? 7.219   6.001  13.269 1.00 20.09 ? 33  THR   A O    1 
ATOM   316  C  CB   . THR   A 1 53  ? 6.795   7.492  10.700 1.00 17.69 ? 33  THR   A CB   1 
ATOM   317  O  OG1  . THR   A 1 53  ? 6.096   7.947  9.533  1.00 18.98 ? 33  THR   A OG1  1 
ATOM   318  C  CG2  . THR   A 1 53  ? 8.293   7.567  10.437 1.00 21.01 ? 33  THR   A CG2  1 
ATOM   319  H  H    . THR   A 1 53  ? 4.641   6.697  11.628 1.00 23.07 ? 33  THR   A H    1 
ATOM   320  H  HA   . THR   A 1 53  ? 6.559   5.517  10.216 1.00 21.61 ? 33  THR   A HA   1 
ATOM   321  H  HB   . THR   A 1 53  ? 6.581   8.062  11.455 1.00 21.25 ? 33  THR   A HB   1 
ATOM   322  H  HG1  . THR   A 1 53  ? 5.267   7.912  9.663  1.00 22.79 ? 33  THR   A HG1  1 
ATOM   323  H  HG21 . THR   A 1 53  ? 8.505   8.392  9.973  1.00 25.23 ? 33  THR   A HG21 1 
ATOM   324  H  HG22 . THR   A 1 53  ? 8.782   7.545  11.275 1.00 25.23 ? 33  THR   A HG22 1 
ATOM   325  H  HG23 . THR   A 1 53  ? 8.571   6.818  9.887  1.00 25.23 ? 33  THR   A HG23 1 
ATOM   326  N  N    . ARG   A 1 54  ? 8.032   4.461  11.829 1.00 18.14 ? 34  ARG   A N    1 
ATOM   327  C  CA   . ARG   A 1 54  ? 8.824   3.756  12.817 1.00 16.27 ? 34  ARG   A CA   1 
ATOM   328  C  C    . ARG   A 1 54  ? 10.202  3.471  12.249 1.00 20.91 ? 34  ARG   A C    1 
ATOM   329  O  O    . ARG   A 1 54  ? 10.414  3.492  11.037 1.00 23.16 ? 34  ARG   A O    1 
ATOM   330  C  CB   . ARG   A 1 54  ? 8.161   2.440  13.222 1.00 22.58 ? 34  ARG   A CB   1 
ATOM   331  C  CG   . ARG   A 1 54  ? 6.817   2.617  13.867 1.00 25.87 ? 34  ARG   A CG   1 
ATOM   332  C  CD   . ARG   A 1 54  ? 6.174   1.270  14.072 1.00 21.54 ? 34  ARG   A CD   1 
ATOM   333  N  NE   . ARG   A 1 54  ? 4.900   1.363  14.770 1.00 22.92 ? 34  ARG   A NE   1 
ATOM   334  C  CZ   . ARG   A 1 54  ? 4.133   0.316  15.029 1.00 25.41 ? 34  ARG   A CZ   1 
ATOM   335  N  NH1  . ARG   A 1 54  ? 4.504   -0.905 14.684 1.00 21.19 ? 34  ARG   A NH1  1 
ATOM   336  N  NH2  . ARG   A 1 54  ? 2.970   0.500  15.647 1.00 26.66 ? 34  ARG   A NH2  1 
ATOM   337  H  H    . ARG   A 1 54  ? 8.116   4.146  11.033 1.00 21.79 ? 34  ARG   A H    1 
ATOM   338  H  HA   . ARG   A 1 54  ? 8.925   4.307  13.609 1.00 19.55 ? 34  ARG   A HA   1 
ATOM   339  H  HB2  . ARG   A 1 54  ? 8.041   1.893  12.430 1.00 27.12 ? 34  ARG   A HB2  1 
ATOM   340  H  HB3  . ARG   A 1 54  ? 8.736   1.981  13.854 1.00 27.12 ? 34  ARG   A HB3  1 
ATOM   341  H  HG2  . ARG   A 1 54  ? 6.924   3.044  14.731 1.00 31.06 ? 34  ARG   A HG2  1 
ATOM   342  H  HG3  . ARG   A 1 54  ? 6.245   3.148  13.291 1.00 31.06 ? 34  ARG   A HG3  1 
ATOM   343  H  HD2  . ARG   A 1 54  ? 6.014   0.861  13.207 1.00 25.87 ? 34  ARG   A HD2  1 
ATOM   344  H  HD3  . ARG   A 1 54  ? 6.767   0.712  14.599 1.00 25.87 ? 34  ARG   A HD3  1 
ATOM   345  H  HE   . ARG   A 1 54  ? 4.571   2.146  14.904 1.00 27.52 ? 34  ARG   A HE   1 
ATOM   346  H  HH11 . ARG   A 1 54  ? 5.254   -1.034 14.283 1.00 25.45 ? 34  ARG   A HH11 1 
ATOM   347  H  HH12 . ARG   A 1 54  ? 3.993   -1.574 14.861 1.00 25.45 ? 34  ARG   A HH12 1 
ATOM   348  H  HH21 . ARG   A 1 54  ? 2.724   1.292  15.874 1.00 32.01 ? 34  ARG   A HH21 1 
ATOM   349  H  HH22 . ARG   A 1 54  ? 2.465   -0.174 15.822 1.00 32.01 ? 34  ARG   A HH22 1 
ATOM   350  N  N    . GLY   A 1 55  ? 11.138  3.189  13.147 1.00 19.08 ? 35  GLY   A N    1 
ATOM   351  C  CA   . GLY   A 1 55  ? 12.441  2.734  12.705 1.00 25.11 ? 35  GLY   A CA   1 
ATOM   352  C  C    . GLY   A 1 55  ? 13.184  3.793  11.910 1.00 26.58 ? 35  GLY   A C    1 
ATOM   353  O  O    . GLY   A 1 55  ? 13.063  4.996  12.152 1.00 19.32 ? 35  GLY   A O    1 
ATOM   354  H  H    . GLY   A 1 55  ? 11.044  3.252  14.000 1.00 22.91 ? 35  GLY   A H    1 
ATOM   355  H  HA2  . GLY   A 1 55  ? 12.979  2.495  13.476 1.00 30.15 ? 35  GLY   A HA2  1 
ATOM   356  H  HA3  . GLY   A 1 55  ? 12.337  1.948  12.147 1.00 30.15 ? 35  GLY   A HA3  1 
ATOM   357  N  N    . GLU   A 1 56  ? 13.973  3.333  10.941 1.00 23.81 ? 36  GLU   A N    1 
ATOM   358  C  CA   . GLU   A 1 56  ? 14.769  4.262  10.149 1.00 25.58 ? 36  GLU   A CA   1 
ATOM   359  C  C    . GLU   A 1 56  ? 13.906  5.226  9.348  1.00 21.69 ? 36  GLU   A C    1 
ATOM   360  O  O    . GLU   A 1 56  ? 14.376  6.317  9.011  1.00 23.35 ? 36  GLU   A O    1 
ATOM   361  C  CB   . GLU   A 1 56  ? 15.705  3.488  9.220  1.00 30.87 ? 36  GLU   A CB   1 
ATOM   362  C  CG   . GLU   A 1 56  ? 16.750  2.670  9.964  1.00 44.35 ? 36  GLU   A CG   1 
ATOM   363  C  CD   . GLU   A 1 56  ? 17.764  3.534  10.692 1.00 54.64 ? 36  GLU   A CD   1 
ATOM   364  O  OE1  . GLU   A 1 56  ? 18.478  4.310  10.023 1.00 59.88 ? 36  GLU   A OE1  1 
ATOM   365  O  OE2  . GLU   A 1 56  ? 17.845  3.442  11.935 1.00 64.31 ? 36  GLU   A OE2  1 
ATOM   366  H  H    . GLU   A 1 56  ? 14.063  2.505  10.727 1.00 28.59 ? 36  GLU   A H    1 
ATOM   367  H  HA   . GLU   A 1 56  ? 15.318  4.790  10.750 1.00 30.72 ? 36  GLU   A HA   1 
ATOM   368  H  HB2  . GLU   A 1 56  ? 15.178  2.878  8.680  1.00 37.06 ? 36  GLU   A HB2  1 
ATOM   369  H  HB3  . GLU   A 1 56  ? 16.171  4.118  8.648  1.00 37.06 ? 36  GLU   A HB3  1 
ATOM   370  H  HG2  . GLU   A 1 56  ? 16.306  2.111  10.621 1.00 53.24 ? 36  GLU   A HG2  1 
ATOM   371  H  HG3  . GLU   A 1 56  ? 17.230  2.117  9.328  1.00 53.24 ? 36  GLU   A HG3  1 
ATOM   372  N  N    . ALA   A 1 57  ? 12.655  4.867  9.051  1.00 21.05 ? 37  ALA   A N    1 
ATOM   373  C  CA   . ALA   A 1 57  ? 11.765  5.802  8.371  1.00 19.61 ? 37  ALA   A CA   1 
ATOM   374  C  C    . ALA   A 1 57  ? 11.593  7.098  9.154  1.00 18.74 ? 37  ALA   A C    1 
ATOM   375  O  O    . ALA   A 1 57  ? 11.220  8.122  8.569  1.00 15.74 ? 37  ALA   A O    1 
ATOM   376  C  CB   . ALA   A 1 57  ? 10.400  5.156  8.125  1.00 26.30 ? 37  ALA   A CB   1 
ATOM   377  H  H    . ALA   A 1 57  ? 12.305  4.102  9.229  1.00 25.28 ? 37  ALA   A H    1 
ATOM   378  H  HA   . ALA   A 1 57  ? 12.147  6.026  7.508  1.00 23.56 ? 37  ALA   A HA   1 
ATOM   379  H  HB1  . ALA   A 1 57  ? 9.827   5.793  7.671  1.00 31.57 ? 37  ALA   A HB1  1 
ATOM   380  H  HB2  . ALA   A 1 57  ? 10.519  4.366  7.574  1.00 31.57 ? 37  ALA   A HB2  1 
ATOM   381  H  HB3  . ALA   A 1 57  ? 10.010  4.909  8.978  1.00 31.57 ? 37  ALA   A HB3  1 
ATOM   382  N  N    . ARG   A 1 58  ? 11.850  7.078  10.464 1.00 18.44 ? 38  ARG   A N    1 
ATOM   383  C  CA   . ARG   A 1 58  ? 11.768  8.299  11.256 1.00 15.07 ? 38  ARG   A CA   1 
ATOM   384  C  C    . ARG   A 1 58  ? 12.739  9.361  10.769 1.00 19.07 ? 38  ARG   A C    1 
ATOM   385  O  O    . ARG   A 1 58  ? 12.497  10.553 10.991 1.00 17.84 ? 38  ARG   A O    1 
ATOM   386  C  CB   . ARG   A 1 58  ? 12.015  7.966  12.726 1.00 18.70 ? 38  ARG   A CB   1 
ATOM   387  C  CG   . ARG   A 1 58  ? 10.837  7.232  13.351 1.00 21.47 ? 38  ARG   A CG   1 
ATOM   388  C  CD   . ARG   A 1 58  ? 11.237  6.409  14.554 1.00 22.86 ? 38  ARG   A CD   1 
ATOM   389  N  NE   . ARG   A 1 58  ? 11.691  7.258  15.648 1.00 22.22 ? 38  ARG   A NE   1 
ATOM   390  C  CZ   . ARG   A 1 58  ? 12.225  6.806  16.776 1.00 18.99 ? 38  ARG   A CZ   1 
ATOM   391  N  NH1  . ARG   A 1 58  ? 12.407  5.513  16.987 1.00 22.70 ? 38  ARG   A NH1  1 
ATOM   392  N  NH2  . ARG   A 1 58  ? 12.600  7.676  17.709 1.00 20.79 ? 38  ARG   A NH2  1 
ATOM   393  H  H    . ARG   A 1 58  ? 12.071  6.377  10.911 1.00 22.14 ? 38  ARG   A H    1 
ATOM   394  H  HA   . ARG   A 1 58  ? 10.871  8.661  11.180 1.00 18.10 ? 38  ARG   A HA   1 
ATOM   395  H  HB2  . ARG   A 1 58  ? 12.798  7.398  12.797 1.00 22.45 ? 38  ARG   A HB2  1 
ATOM   396  H  HB3  . ARG   A 1 58  ? 12.154  8.789  13.220 1.00 22.45 ? 38  ARG   A HB3  1 
ATOM   397  H  HG2  . ARG   A 1 58  ? 10.176  7.881  13.638 1.00 25.78 ? 38  ARG   A HG2  1 
ATOM   398  H  HG3  . ARG   A 1 58  ? 10.451  6.633  12.693 1.00 25.78 ? 38  ARG   A HG3  1 
ATOM   399  H  HD2  . ARG   A 1 58  ? 10.472  5.898  14.862 1.00 27.45 ? 38  ARG   A HD2  1 
ATOM   400  H  HD3  . ARG   A 1 58  ? 11.962  5.813  14.309 1.00 27.45 ? 38  ARG   A HD3  1 
ATOM   401  H  HE   . ARG   A 1 58  ? 11.607  8.109  15.557 1.00 26.68 ? 38  ARG   A HE   1 
ATOM   402  H  HH11 . ARG   A 1 58  ? 12.170  4.940  16.391 1.00 27.26 ? 38  ARG   A HH11 1 
ATOM   403  H  HH12 . ARG   A 1 58  ? 12.757  5.244  17.725 1.00 27.26 ? 38  ARG   A HH12 1 
ATOM   404  H  HH21 . ARG   A 1 58  ? 12.488  8.519  17.581 1.00 24.96 ? 38  ARG   A HH21 1 
ATOM   405  H  HH22 . ARG   A 1 58  ? 12.949  7.395  18.443 1.00 24.96 ? 38  ARG   A HH22 1 
ATOM   406  N  N    . LEU   A 1 59  ? 13.824  8.961  10.101 1.00 16.88 ? 39  LEU   A N    1 
ATOM   407  C  CA   . LEU   A 1 59  ? 14.769  9.930  9.562  1.00 17.76 ? 39  LEU   A CA   1 
ATOM   408  C  C    . LEU   A 1 59  ? 14.166  10.774 8.449  1.00 20.76 ? 39  LEU   A C    1 
ATOM   409  O  O    . LEU   A 1 59  ? 14.735  11.815 8.110  1.00 21.48 ? 39  LEU   A O    1 
ATOM   410  C  CB   . LEU   A 1 59  ? 16.015  9.213  9.041  1.00 17.16 ? 39  LEU   A CB   1 
ATOM   411  C  CG   . LEU   A 1 59  ? 16.833  8.518  10.125 1.00 22.47 ? 39  LEU   A CG   1 
ATOM   412  C  CD1  . LEU   A 1 59  ? 18.021  7.756  9.577  1.00 32.21 ? 39  LEU   A CD1  1 
ATOM   413  C  CD2  . LEU   A 1 59  ? 17.300  9.553  11.153 1.00 28.88 ? 39  LEU   A CD2  1 
ATOM   414  H  H    . LEU   A 1 59  ? 14.031  8.140  9.949  1.00 20.27 ? 39  LEU   A H    1 
ATOM   415  H  HA   . LEU   A 1 59  ? 15.035  10.535 10.271 1.00 21.32 ? 39  LEU   A HA   1 
ATOM   416  H  HB2  . LEU   A 1 59  ? 15.741  8.539  8.400  1.00 20.61 ? 39  LEU   A HB2  1 
ATOM   417  H  HB3  . LEU   A 1 59  ? 16.590  9.863  8.608  1.00 20.61 ? 39  LEU   A HB3  1 
ATOM   418  H  HG   . LEU   A 1 59  ? 16.262  7.882  10.585 1.00 26.98 ? 39  LEU   A HG   1 
ATOM   419  H  HD11 . LEU   A 1 59  ? 18.487  7.328  10.312 1.00 38.67 ? 39  LEU   A HD11 1 
ATOM   420  H  HD12 . LEU   A 1 59  ? 17.704  7.087  8.951  1.00 38.67 ? 39  LEU   A HD12 1 
ATOM   421  H  HD13 . LEU   A 1 59  ? 18.613  8.378  9.126  1.00 38.67 ? 39  LEU   A HD13 1 
ATOM   422  H  HD21 . LEU   A 1 59  ? 18.009  9.166  11.690 1.00 34.67 ? 39  LEU   A HD21 1 
ATOM   423  H  HD22 . LEU   A 1 59  ? 17.630  10.335 10.684 1.00 34.67 ? 39  LEU   A HD22 1 
ATOM   424  H  HD23 . LEU   A 1 59  ? 16.552  9.798  11.719 1.00 34.67 ? 39  LEU   A HD23 1 
ATOM   425  N  N    . LYS   A 1 60  ? 13.040  10.354 7.871  1.00 21.19 ? 40  LYS   A N    1 
ATOM   426  C  CA   . LYS   A 1 60  ? 12.407  11.079 6.779  1.00 17.65 ? 40  LYS   A CA   1 
ATOM   427  C  C    . LYS   A 1 60  ? 11.036  11.633 7.156  1.00 16.52 ? 40  LYS   A C    1 
ATOM   428  O  O    . LYS   A 1 60  ? 10.349  12.196 6.299  1.00 18.37 ? 40  LYS   A O    1 
ATOM   429  C  CB   . LYS   A 1 60  ? 12.289  10.180 5.545  1.00 20.19 ? 40  LYS   A CB   1 
ATOM   430  C  CG   . LYS   A 1 60  ? 13.627  9.747  4.943  1.00 26.47 ? 40  LYS   A CG   1 
ATOM   431  H  H    . LYS   A 1 60  ? 12.619  9.640  8.099  1.00 25.45 ? 40  LYS   A H    1 
ATOM   432  H  HA   . LYS   A 1 60  ? 12.968  11.832 6.537  1.00 21.19 ? 40  LYS   A HA   1 
ATOM   433  H  HB2  . LYS   A 1 60  ? 11.804  9.377  5.792  1.00 24.25 ? 40  LYS   A HB2  1 
ATOM   434  H  HB3  . LYS   A 1 60  ? 11.799  10.659 4.858  1.00 24.25 ? 40  LYS   A HB3  1 
ATOM   435  N  N    . ARG   A 1 61  ? 10.627  11.506 8.419  1.00 16.62 ? 41  ARG   A N    1 
ATOM   436  C  CA   . ARG   A 1 61  ? 9.307   11.983 8.816  1.00 16.86 ? 41  ARG   A CA   1 
ATOM   437  C  C    . ARG   A 1 61  ? 9.176   13.494 8.663  1.00 17.59 ? 41  ARG   A C    1 
ATOM   438  O  O    . ARG   A 1 61  ? 8.063   13.992 8.463  1.00 17.21 ? 41  ARG   A O    1 
ATOM   439  C  CB   . ARG   A 1 61  ? 9.012   11.556 10.256 1.00 17.63 ? 41  ARG   A CB   1 
ATOM   440  C  CG   . ARG   A 1 61  ? 7.556   11.691 10.682 1.00 16.13 ? 41  ARG   A CG   1 
ATOM   441  C  CD   . ARG   A 1 61  ? 7.356   11.196 12.109 1.00 17.12 ? 41  ARG   A CD   1 
ATOM   442  N  NE   . ARG   A 1 61  ? 7.980   12.083 13.085 1.00 21.79 ? 41  ARG   A NE   1 
ATOM   443  C  CZ   . ARG   A 1 61  ? 8.179   11.774 14.359 1.00 28.49 ? 41  ARG   A CZ   1 
ATOM   444  N  NH1  . ARG   A 1 61  ? 7.834   10.595 14.846 1.00 26.91 ? 41  ARG   A NH1  1 
ATOM   445  N  NH2  . ARG   A 1 61  ? 8.742   12.669 15.165 1.00 29.56 ? 41  ARG   A NH2  1 
ATOM   446  H  H    . ARG   A 1 61  ? 11.087  11.154 9.054  1.00 19.96 ? 41  ARG   A H    1 
ATOM   447  H  HA   . ARG   A 1 61  ? 8.642   11.570 8.243  1.00 20.25 ? 41  ARG   A HA   1 
ATOM   448  H  HB2  . ARG   A 1 61  ? 9.262   10.624 10.359 1.00 21.17 ? 41  ARG   A HB2  1 
ATOM   449  H  HB3  . ARG   A 1 61  ? 9.544   12.103 10.855 1.00 21.17 ? 41  ARG   A HB3  1 
ATOM   450  H  HG2  . ARG   A 1 61  ? 7.295   12.624 10.643 1.00 19.37 ? 41  ARG   A HG2  1 
ATOM   451  H  HG3  . ARG   A 1 61  ? 6.998   11.159 10.093 1.00 19.37 ? 41  ARG   A HG3  1 
ATOM   452  H  HD2  . ARG   A 1 61  ? 6.406   11.154 12.302 1.00 20.56 ? 41  ARG   A HD2  1 
ATOM   453  H  HD3  . ARG   A 1 61  ? 7.755   10.317 12.200 1.00 20.56 ? 41  ARG   A HD3  1 
ATOM   454  H  HE   . ARG   A 1 61  ? 8.236   12.859 12.816 1.00 26.17 ? 41  ARG   A HE   1 
ATOM   455  H  HH11 . ARG   A 1 61  ? 7.469   10.007 14.336 1.00 32.31 ? 41  ARG   A HH11 1 
ATOM   456  H  HH12 . ARG   A 1 61  ? 7.974   10.416 15.676 1.00 32.31 ? 41  ARG   A HH12 1 
ATOM   457  H  HH21 . ARG   A 1 61  ? 8.972   13.439 14.859 1.00 35.49 ? 41  ARG   A HH21 1 
ATOM   458  H  HH22 . ARG   A 1 61  ? 8.877   12.478 15.993 1.00 35.49 ? 41  ARG   A HH22 1 
ATOM   459  N  N    . HIS   A 1 62  ? 10.287  14.230 8.712  1.00 18.15 ? 42  HIS   A N    1 
ATOM   460  C  CA   . HIS   A 1 62  ? 10.219  15.676 8.539  1.00 17.02 ? 42  HIS   A CA   1 
ATOM   461  C  C    . HIS   A 1 62  ? 9.711   16.069 7.158  1.00 16.16 ? 42  HIS   A C    1 
ATOM   462  O  O    . HIS   A 1 62  ? 9.234   17.194 6.985  1.00 16.43 ? 42  HIS   A O    1 
ATOM   463  C  CB   . HIS   A 1 62  ? 11.591  16.302 8.800  1.00 18.87 ? 42  HIS   A CB   1 
ATOM   464  C  CG   . HIS   A 1 62  ? 12.652  15.869 7.838  1.00 15.45 ? 42  HIS   A CG   1 
ATOM   465  N  ND1  . HIS   A 1 62  ? 13.221  14.613 7.868  1.00 21.50 ? 42  HIS   A ND1  1 
ATOM   466  C  CD2  . HIS   A 1 62  ? 13.258  16.533 6.826  1.00 22.07 ? 42  HIS   A CD2  1 
ATOM   467  C  CE1  . HIS   A 1 62  ? 14.124  14.519 6.909  1.00 24.03 ? 42  HIS   A CE1  1 
ATOM   468  N  NE2  . HIS   A 1 62  ? 14.165  15.670 6.261  1.00 22.36 ? 42  HIS   A NE2  1 
ATOM   469  H  H    . HIS   A 1 62  ? 11.078  13.920 8.843  1.00 21.80 ? 42  HIS   A H    1 
ATOM   470  H  HA   . HIS   A 1 62  ? 9.601   16.038 9.193  1.00 20.44 ? 42  HIS   A HA   1 
ATOM   471  H  HB2  . HIS   A 1 62  ? 11.511  17.267 8.737  1.00 22.67 ? 42  HIS   A HB2  1 
ATOM   472  H  HB3  . HIS   A 1 62  ? 11.882  16.055 9.692  1.00 22.67 ? 42  HIS   A HB3  1 
ATOM   473  H  HD2  . HIS   A 1 62  ? 13.087  17.406 6.557  1.00 26.50 ? 42  HIS   A HD2  1 
ATOM   474  H  HE1  . HIS   A 1 62  ? 14.643  13.770 6.722  1.00 28.85 ? 42  HIS   A HE1  1 
ATOM   475  H  HE2  . HIS   A 1 62  ? 14.679  15.851 5.596  1.00 26.85 ? 42  HIS   A HE2  1 
ATOM   476  N  N    . LEU   A 1 63  ? 9.781   15.170 6.173  1.00 16.48 ? 43  LEU   A N    1 
ATOM   477  C  CA   . LEU   A 1 63  ? 9.255   15.477 4.847  1.00 13.46 ? 43  LEU   A CA   1 
ATOM   478  C  C    . LEU   A 1 63  ? 7.734   15.567 4.835  1.00 19.50 ? 43  LEU   A C    1 
ATOM   479  O  O    . LEU   A 1 63  ? 7.153   15.970 3.819  1.00 15.67 ? 43  LEU   A O    1 
ATOM   480  C  CB   . LEU   A 1 63  ? 9.738   14.434 3.842  1.00 14.37 ? 43  LEU   A CB   1 
ATOM   481  C  CG   . LEU   A 1 63  ? 11.255  14.449 3.621  1.00 21.11 ? 43  LEU   A CG   1 
ATOM   482  C  CD1  . LEU   A 1 63  ? 11.634  13.431 2.553  1.00 24.73 ? 43  LEU   A CD1  1 
ATOM   483  C  CD2  . LEU   A 1 63  ? 11.776  15.833 3.248  1.00 19.99 ? 43  LEU   A CD2  1 
ATOM   484  H  H    . LEU   A 1 63  ? 10.125  14.385 6.247  1.00 19.80 ? 43  LEU   A H    1 
ATOM   485  H  HA   . LEU   A 1 63  ? 9.592   16.343 4.573  1.00 16.17 ? 43  LEU   A HA   1 
ATOM   486  H  HB2  . LEU   A 1 63  ? 9.493   13.552 4.164  1.00 17.26 ? 43  LEU   A HB2  1 
ATOM   487  H  HB3  . LEU   A 1 63  ? 9.312   14.602 2.987  1.00 17.26 ? 43  LEU   A HB3  1 
ATOM   488  H  HG   . LEU   A 1 63  ? 11.690  14.184 4.446  1.00 25.34 ? 43  LEU   A HG   1 
ATOM   489  H  HD11 . LEU   A 1 63  ? 12.596  13.443 2.433  1.00 29.70 ? 43  LEU   A HD11 1 
ATOM   490  H  HD12 . LEU   A 1 63  ? 11.348  12.550 2.841  1.00 29.70 ? 43  LEU   A HD12 1 
ATOM   491  H  HD13 . LEU   A 1 63  ? 11.193  13.667 1.722  1.00 29.70 ? 43  LEU   A HD13 1 
ATOM   492  H  HD21 . LEU   A 1 63  ? 12.678  15.747 2.901  1.00 24.00 ? 43  LEU   A HD21 1 
ATOM   493  H  HD22 . LEU   A 1 63  ? 11.196  16.216 2.571  1.00 24.00 ? 43  LEU   A HD22 1 
ATOM   494  H  HD23 . LEU   A 1 63  ? 11.778  16.395 4.039  1.00 24.00 ? 43  LEU   A HD23 1 
ATOM   495  N  N    . LEU   A 1 64  ? 7.079   15.221 5.937  1.00 14.73 ? 44  LEU   A N    1 
ATOM   496  C  CA   . LEU   A 1 64  ? 5.634   15.378 6.047  1.00 14.90 ? 44  LEU   A CA   1 
ATOM   497  C  C    . LEU   A 1 64  ? 5.237   16.777 6.488  1.00 16.15 ? 44  LEU   A C    1 
ATOM   498  O  O    . LEU   A 1 64  ? 4.037   17.051 6.621  1.00 14.76 ? 44  LEU   A O    1 
ATOM   499  C  CB   . LEU   A 1 64  ? 5.066   14.364 7.034  1.00 14.36 ? 44  LEU   A CB   1 
ATOM   500  C  CG   . LEU   A 1 64  ? 5.264   12.899 6.659  1.00 16.68 ? 44  LEU   A CG   1 
ATOM   501  C  CD1  . LEU   A 1 64  ? 4.611   11.977 7.684  1.00 18.60 ? 44  LEU   A CD1  1 
ATOM   502  C  CD2  . LEU   A 1 64  ? 4.725   12.619 5.270  1.00 20.70 ? 44  LEU   A CD2  1 
ATOM   503  H  H    . LEU   A 1 64  ? 7.448   14.889 6.639  1.00 17.69 ? 44  LEU   A H    1 
ATOM   504  H  HA   . LEU   A 1 64  ? 5.231   15.219 5.180  1.00 17.90 ? 44  LEU   A HA   1 
ATOM   505  H  HB2  . LEU   A 1 64  ? 5.490   14.503 7.895  1.00 17.24 ? 44  LEU   A HB2  1 
ATOM   506  H  HB3  . LEU   A 1 64  ? 4.112   14.517 7.115  1.00 17.24 ? 44  LEU   A HB3  1 
ATOM   507  H  HG   . LEU   A 1 64  ? 6.214   12.706 6.651  1.00 20.03 ? 44  LEU   A HG   1 
ATOM   508  H  HD11 . LEU   A 1 64  ? 4.761   11.056 7.421  1.00 22.34 ? 44  LEU   A HD11 1 
ATOM   509  H  HD12 . LEU   A 1 64  ? 5.008   12.142 8.554  1.00 22.34 ? 44  LEU   A HD12 1 
ATOM   510  H  HD13 . LEU   A 1 64  ? 3.659   12.162 7.713  1.00 22.34 ? 44  LEU   A HD13 1 
ATOM   511  H  HD21 . LEU   A 1 64  ? 4.685   11.659 5.135  1.00 24.85 ? 44  LEU   A HD21 1 
ATOM   512  H  HD22 . LEU   A 1 64  ? 3.837   13.002 5.194  1.00 24.85 ? 44  LEU   A HD22 1 
ATOM   513  H  HD23 . LEU   A 1 64  ? 5.316   13.021 4.614  1.00 24.85 ? 44  LEU   A HD23 1 
ATOM   514  N  N    . PHE   A 1 65  ? 6.211   17.644 6.738  1.00 14.05 ? 45  PHE   A N    1 
ATOM   515  C  CA   . PHE   A 1 65  ? 5.984   19.002 7.195  1.00 13.33 ? 45  PHE   A CA   1 
ATOM   516  C  C    . PHE   A 1 65  ? 6.220   20.011 6.075  1.00 15.66 ? 45  PHE   A C    1 
ATOM   517  O  O    . PHE   A 1 65  ? 6.990   19.783 5.138  1.00 17.88 ? 45  PHE   A O    1 
ATOM   518  C  CB   . PHE   A 1 65  ? 6.923   19.356 8.357  1.00 13.31 ? 45  PHE   A CB   1 
ATOM   519  C  CG   . PHE   A 1 65  ? 6.614   18.659 9.656  1.00 16.53 ? 45  PHE   A CG   1 
ATOM   520  C  CD1  . PHE   A 1 65  ? 6.924   17.323 9.840  1.00 16.01 ? 45  PHE   A CD1  1 
ATOM   521  C  CD2  . PHE   A 1 65  ? 6.061   19.363 10.725 1.00 15.77 ? 45  PHE   A CD2  1 
ATOM   522  C  CE1  . PHE   A 1 65  ? 6.658   16.700 11.052 1.00 19.67 ? 45  PHE   A CE1  1 
ATOM   523  C  CE2  . PHE   A 1 65  ? 5.795   18.741 11.935 1.00 15.29 ? 45  PHE   A CE2  1 
ATOM   524  C  CZ   . PHE   A 1 65  ? 6.090   17.409 12.098 1.00 16.90 ? 45  PHE   A CZ   1 
ATOM   525  H  H    . PHE   A 1 65  ? 7.046   17.459 6.646  1.00 16.88 ? 45  PHE   A H    1 
ATOM   526  H  HA   . PHE   A 1 65  ? 5.069   19.091 7.502  1.00 16.01 ? 45  PHE   A HA   1 
ATOM   527  H  HB2  . PHE   A 1 65  ? 7.829   19.118 8.105  1.00 15.99 ? 45  PHE   A HB2  1 
ATOM   528  H  HB3  . PHE   A 1 65  ? 6.870   20.311 8.517  1.00 15.99 ? 45  PHE   A HB3  1 
ATOM   529  H  HD1  . PHE   A 1 65  ? 7.303   16.836 9.144  1.00 19.23 ? 45  PHE   A HD1  1 
ATOM   530  H  HD2  . PHE   A 1 65  ? 5.856   20.264 10.621 1.00 18.94 ? 45  PHE   A HD2  1 
ATOM   531  H  HE1  . PHE   A 1 65  ? 6.858   15.798 11.161 1.00 23.62 ? 45  PHE   A HE1  1 
ATOM   532  H  HE2  . PHE   A 1 65  ? 5.414   19.223 12.633 1.00 18.37 ? 45  PHE   A HE2  1 
ATOM   533  H  HZ   . PHE   A 1 65  ? 5.913   16.987 12.907 1.00 20.30 ? 45  PHE   A HZ   1 
ATOM   534  N  N    . THR   A 1 66  ? 5.587   21.169 6.223  1.00 15.77 ? 46  THR   A N    1 
ATOM   535  C  CA   . THR   A 1 66  ? 5.958   22.318 5.415  1.00 17.67 ? 46  THR   A CA   1 
ATOM   536  C  C    . THR   A 1 66  ? 7.395   22.725 5.734  1.00 20.50 ? 46  THR   A C    1 
ATOM   537  O  O    . THR   A 1 66  ? 7.964   22.332 6.756  1.00 17.18 ? 46  THR   A O    1 
ATOM   538  C  CB   . THR   A 1 66  ? 5.017   23.486 5.686  1.00 21.57 ? 46  THR   A CB   1 
ATOM   539  O  OG1  . THR   A 1 66  ? 5.142   23.878 7.056  1.00 21.19 ? 46  THR   A OG1  1 
ATOM   540  C  CG2  . THR   A 1 66  ? 3.588   23.084 5.405  1.00 21.56 ? 46  THR   A CG2  1 
ATOM   541  H  H    . THR   A 1 66  ? 4.948   21.313 6.780  1.00 18.95 ? 46  THR   A H    1 
ATOM   542  H  HA   . THR   A 1 66  ? 5.903   22.087 4.475  1.00 21.22 ? 46  THR   A HA   1 
ATOM   543  H  HB   . THR   A 1 66  ? 5.248   24.232 5.111  1.00 25.91 ? 46  THR   A HB   1 
ATOM   544  H  HG1  . THR   A 1 66  ? 5.884   24.249 7.181  1.00 25.44 ? 46  THR   A HG1  1 
ATOM   545  H  HG21 . THR   A 1 66  ? 3.008   23.859 5.467  1.00 25.89 ? 46  THR   A HG21 1 
ATOM   546  H  HG22 . THR   A 1 66  ? 3.519   22.710 4.513  1.00 25.89 ? 46  THR   A HG22 1 
ATOM   547  H  HG23 . THR   A 1 66  ? 3.296   22.419 6.048  1.00 25.89 ? 46  THR   A HG23 1 
ATOM   548  N  N    . GLU   A 1 67  ? 7.980   23.540 4.853  1.00 19.42 ? 47  GLU   A N    1 
ATOM   549  C  CA   . GLU   A 1 67  ? 9.381   23.909 5.044  1.00 21.84 ? 47  GLU   A CA   1 
ATOM   550  C  C    . GLU   A 1 67  ? 9.576   24.632 6.372  1.00 19.56 ? 47  GLU   A C    1 
ATOM   551  O  O    . GLU   A 1 67  ? 10.587  24.430 7.058  1.00 20.91 ? 47  GLU   A O    1 
ATOM   552  C  CB   . GLU   A 1 67  ? 9.875   24.771 3.885  1.00 25.03 ? 47  GLU   A CB   1 
ATOM   553  C  CG   . GLU   A 1 67  ? 11.390  24.972 3.889  1.00 38.95 ? 47  GLU   A CG   1 
ATOM   554  C  CD   . GLU   A 1 67  ? 12.166  23.678 3.661  1.00 57.95 ? 47  GLU   A CD   1 
ATOM   555  O  OE1  . GLU   A 1 67  ? 11.791  22.899 2.758  1.00 61.95 ? 47  GLU   A OE1  1 
ATOM   556  O  OE2  . GLU   A 1 67  ? 13.152  23.438 4.392  1.00 49.61 ? 47  GLU   A OE2  1 
ATOM   557  H  H    . GLU   A 1 67  ? 7.602   23.882 4.160  1.00 23.32 ? 47  GLU   A H    1 
ATOM   558  H  HA   . GLU   A 1 67  ? 9.916   23.100 5.065  1.00 26.23 ? 47  GLU   A HA   1 
ATOM   559  H  HB2  . GLU   A 1 67  ? 9.633   24.343 3.049  1.00 30.05 ? 47  GLU   A HB2  1 
ATOM   560  H  HB3  . GLU   A 1 67  ? 9.458   25.645 3.942  1.00 30.05 ? 47  GLU   A HB3  1 
ATOM   561  H  HG2  . GLU   A 1 67  ? 11.627  25.590 3.180  1.00 46.76 ? 47  GLU   A HG2  1 
ATOM   562  H  HG3  . GLU   A 1 67  ? 11.660  25.335 4.747  1.00 46.76 ? 47  GLU   A HG3  1 
ATOM   563  N  N    . ASP   A 1 68  ? 8.608   25.465 6.759  1.00 19.29 ? 48  ASP   A N    1 
ATOM   564  C  CA   . ASP   A 1 68  ? 8.635   26.187 8.024  1.00 21.92 ? 48  ASP   A CA   1 
ATOM   565  C  C    . ASP   A 1 68  ? 7.801   25.502 9.103  1.00 23.68 ? 48  ASP   A C    1 
ATOM   566  O  O    . ASP   A 1 68  ? 7.405   26.149 10.079 1.00 22.21 ? 48  ASP   A O    1 
ATOM   567  C  CB   . ASP   A 1 68  ? 8.141   27.619 7.816  1.00 26.01 ? 48  ASP   A CB   1 
ATOM   568  C  CG   . ASP   A 1 68  ? 6.708   27.678 7.292  1.00 32.45 ? 48  ASP   A CG   1 
ATOM   569  O  OD1  . ASP   A 1 68  ? 6.145   26.621 6.924  1.00 40.07 ? 48  ASP   A OD1  1 
ATOM   570  O  OD2  . ASP   A 1 68  ? 6.144   28.790 7.254  1.00 54.80 ? 48  ASP   A OD2  1 
ATOM   571  H  H    . ASP   A 1 68  ? 7.907   25.629 6.289  1.00 23.17 ? 48  ASP   A H    1 
ATOM   572  H  HA   . ASP   A 1 68  ? 9.551   26.232 8.341  1.00 26.32 ? 48  ASP   A HA   1 
ATOM   573  H  HB2  . ASP   A 1 68  ? 8.171   28.090 8.663  1.00 31.23 ? 48  ASP   A HB2  1 
ATOM   574  H  HB3  . ASP   A 1 68  ? 8.715   28.061 7.170  1.00 31.23 ? 48  ASP   A HB3  1 
ATOM   575  N  N    . GLY   A 1 69  ? 7.522   24.210 8.942  1.00 17.07 ? 49  GLY   A N    1 
ATOM   576  C  CA   . GLY   A 1 69  ? 6.695   23.506 9.892  1.00 18.46 ? 49  GLY   A CA   1 
ATOM   577  C  C    . GLY   A 1 69  ? 7.337   23.398 11.260 1.00 13.77 ? 49  GLY   A C    1 
ATOM   578  O  O    . GLY   A 1 69  ? 8.557   23.431 11.424 1.00 17.21 ? 49  GLY   A O    1 
ATOM   579  H  H    . GLY   A 1 69  ? 7.803   23.726 8.289  1.00 20.50 ? 49  GLY   A H    1 
ATOM   580  H  HA2  . GLY   A 1 69  ? 5.848   23.969 9.987  1.00 22.17 ? 49  GLY   A HA2  1 
ATOM   581  H  HA3  . GLY   A 1 69  ? 6.520   22.610 9.564  1.00 22.17 ? 49  GLY   A HA3  1 
ATOM   582  N  N    . VAL   A 1 70  ? 6.481   23.247 12.261 1.00 12.59 ? 50  VAL   A N    1 
ATOM   583  C  CA   . VAL   A 1 70  ? 6.883   23.178 13.658 1.00 12.82 ? 50  VAL   A CA   1 
ATOM   584  C  C    . VAL   A 1 70  ? 6.341   21.890 14.256 1.00 14.36 ? 50  VAL   A C    1 
ATOM   585  O  O    . VAL   A 1 70  ? 5.200   21.500 13.985 1.00 14.31 ? 50  VAL   A O    1 
ATOM   586  C  CB   . VAL   A 1 70  ? 6.374   24.404 14.446 1.00 17.00 ? 50  VAL   A CB   1 
ATOM   587  C  CG1  . VAL   A 1 70  ? 6.609   24.223 15.936 1.00 23.47 ? 50  VAL   A CG1  1 
ATOM   588  C  CG2  . VAL   A 1 70  ? 7.036   25.678 13.944 1.00 24.66 ? 50  VAL   A CG2  1 
ATOM   589  H  H    . VAL   A 1 70  ? 5.631   23.180 12.151 1.00 15.13 ? 50  VAL   A H    1 
ATOM   590  H  HA   . VAL   A 1 70  ? 7.851   23.158 13.717 1.00 15.40 ? 50  VAL   A HA   1 
ATOM   591  H  HB   . VAL   A 1 70  ? 5.418   24.491 14.305 1.00 20.41 ? 50  VAL   A HB   1 
ATOM   592  H  HG11 . VAL   A 1 70  ? 6.532   25.086 16.373 1.00 28.18 ? 50  VAL   A HG11 1 
ATOM   593  H  HG12 . VAL   A 1 70  ? 5.944   23.613 16.292 1.00 28.18 ? 50  VAL   A HG12 1 
ATOM   594  H  HG13 . VAL   A 1 70  ? 7.499   23.863 16.073 1.00 28.18 ? 50  VAL   A HG13 1 
ATOM   595  H  HG21 . VAL   A 1 70  ? 6.692   26.432 14.448 1.00 29.61 ? 50  VAL   A HG21 1 
ATOM   596  H  HG22 . VAL   A 1 70  ? 7.995   25.606 14.070 1.00 29.61 ? 50  VAL   A HG22 1 
ATOM   597  H  HG23 . VAL   A 1 70  ? 6.833   25.789 13.002 1.00 29.61 ? 50  VAL   A HG23 1 
ATOM   598  N  N    . GLY   A 1 71  ? 7.165   21.224 15.061 1.00 12.49 ? 51  GLY   A N    1 
ATOM   599  C  CA   . GLY   A 1 71  ? 6.716   20.079 15.823 1.00 15.32 ? 51  GLY   A CA   1 
ATOM   600  C  C    . GLY   A 1 71  ? 7.368   20.101 17.191 1.00 19.22 ? 51  GLY   A C    1 
ATOM   601  O  O    . GLY   A 1 71  ? 8.343   20.820 17.419 1.00 21.20 ? 51  GLY   A O    1 
ATOM   602  H  H    . GLY   A 1 71  ? 7.993   21.422 15.180 1.00 15.01 ? 51  GLY   A H    1 
ATOM   603  H  HA2  . GLY   A 1 71  ? 5.757   20.105 15.920 1.00 18.41 ? 51  GLY   A HA2  1 
ATOM   604  H  HA3  . GLY   A 1 71  ? 6.965   19.260 15.368 1.00 18.41 ? 51  GLY   A HA3  1 
ATOM   605  N  N    . GLY   A 1 72  ? 6.821   19.318 18.107 1.00 13.36 ? 52  GLY   A N    1 
ATOM   606  C  CA   . GLY   A 1 72  ? 7.479   19.183 19.389 1.00 11.06 ? 52  GLY   A CA   1 
ATOM   607  C  C    . GLY   A 1 72  ? 6.556   18.747 20.509 1.00 13.54 ? 52  GLY   A C    1 
ATOM   608  O  O    . GLY   A 1 72  ? 5.412   18.337 20.295 1.00 13.85 ? 52  GLY   A O    1 
ATOM   609  H  H    . GLY   A 1 72  ? 6.094   18.869 18.015 1.00 16.05 ? 52  GLY   A H    1 
ATOM   610  H  HA2  . GLY   A 1 72  ? 8.191   18.534 19.309 1.00 13.29 ? 52  GLY   A HA2  1 
ATOM   611  H  HA3  . GLY   A 1 72  ? 7.871   20.034 19.639 1.00 13.29 ? 52  GLY   A HA3  1 
ATOM   612  N  N    . LEU   A 1 73  ? 7.103   18.846 21.719 1.00 12.18 ? 53  LEU   A N    1 
ATOM   613  C  CA   . LEU   A 1 73  ? 6.463   18.380 22.940 1.00 14.31 ? 53  LEU   A CA   1 
ATOM   614  C  C    . LEU   A 1 73  ? 5.941   19.581 23.714 1.00 13.57 ? 53  LEU   A C    1 
ATOM   615  O  O    . LEU   A 1 73  ? 6.715   20.460 24.098 1.00 14.52 ? 53  LEU   A O    1 
ATOM   616  C  CB   . LEU   A 1 73  ? 7.465   17.602 23.791 1.00 12.95 ? 53  LEU   A CB   1 
ATOM   617  C  CG   . LEU   A 1 73  ? 7.014   17.185 25.189 1.00 13.21 ? 53  LEU   A CG   1 
ATOM   618  C  CD1  . LEU   A 1 73  ? 5.816   16.278 25.087 1.00 11.91 ? 53  LEU   A CD1  1 
ATOM   619  C  CD2  . LEU   A 1 73  ? 8.169   16.506 25.920 1.00 13.82 ? 53  LEU   A CD2  1 
ATOM   620  H  H    . LEU   A 1 73  ? 7.877   19.195 21.859 1.00 14.63 ? 53  LEU   A H    1 
ATOM   621  H  HA   . LEU   A 1 73  ? 5.718   17.800 22.720 1.00 17.19 ? 53  LEU   A HA   1 
ATOM   622  H  HB2  . LEU   A 1 73  ? 7.700   16.791 23.313 1.00 15.56 ? 53  LEU   A HB2  1 
ATOM   623  H  HB3  . LEU   A 1 73  ? 8.258   18.150 23.899 1.00 15.56 ? 53  LEU   A HB3  1 
ATOM   624  H  HG   . LEU   A 1 73  ? 6.758   17.972 25.695 1.00 15.87 ? 53  LEU   A HG   1 
ATOM   625  H  HD11 . LEU   A 1 73  ? 5.524   16.041 25.980 1.00 14.31 ? 53  LEU   A HD11 1 
ATOM   626  H  HD12 . LEU   A 1 73  ? 5.103   16.743 24.622 1.00 14.31 ? 53  LEU   A HD12 1 
ATOM   627  H  HD13 . LEU   A 1 73  ? 6.066   15.479 24.597 1.00 14.31 ? 53  LEU   A HD13 1 
ATOM   628  H  HD21 . LEU   A 1 73  ? 7.886   16.285 26.821 1.00 16.61 ? 53  LEU   A HD21 1 
ATOM   629  H  HD22 . LEU   A 1 73  ? 8.414   15.698 25.442 1.00 16.61 ? 53  LEU   A HD22 1 
ATOM   630  H  HD23 . LEU   A 1 73  ? 8.924   17.115 25.951 1.00 16.61 ? 53  LEU   A HD23 1 
ATOM   631  N  N    . TRP   A 1 74  ? 4.638   19.615 23.962 1.00 11.57 ? 54  TRP   A N    1 
ATOM   632  C  CA   . TRP   A 1 74  ? 4.064   20.803 24.577 1.00 16.52 ? 54  TRP   A CA   1 
ATOM   633  C  C    . TRP   A 1 74  ? 3.982   20.706 26.092 1.00 20.10 ? 54  TRP   A C    1 
ATOM   634  O  O    . TRP   A 1 74  ? 3.730   21.721 26.747 1.00 19.96 ? 54  TRP   A O    1 
ATOM   635  C  CB   . TRP   A 1 74  ? 2.682   21.093 23.969 1.00 14.78 ? 54  TRP   A CB   1 
ATOM   636  C  CG   . TRP   A 1 74  ? 2.703   22.312 23.062 1.00 13.81 ? 54  TRP   A CG   1 
ATOM   637  C  CD1  . TRP   A 1 74  ? 2.004   23.473 23.233 1.00 20.41 ? 54  TRP   A CD1  1 
ATOM   638  C  CD2  . TRP   A 1 74  ? 3.502   22.501 21.877 1.00 13.65 ? 54  TRP   A CD2  1 
ATOM   639  N  NE1  . TRP   A 1 74  ? 2.301   24.360 22.225 1.00 20.48 ? 54  TRP   A NE1  1 
ATOM   640  C  CE2  . TRP   A 1 74  ? 3.218   23.789 21.383 1.00 15.66 ? 54  TRP   A CE2  1 
ATOM   641  C  CE3  . TRP   A 1 74  ? 4.414   21.702 21.184 1.00 17.32 ? 54  TRP   A CE3  1 
ATOM   642  C  CZ2  . TRP   A 1 74  ? 3.814   24.298 20.226 1.00 18.26 ? 54  TRP   A CZ2  1 
ATOM   643  C  CZ3  . TRP   A 1 74  ? 5.015   22.213 20.036 1.00 16.71 ? 54  TRP   A CZ3  1 
ATOM   644  C  CH2  . TRP   A 1 74  ? 4.711   23.497 19.571 1.00 18.49 ? 54  TRP   A CH2  1 
ATOM   645  H  H    . TRP   A 1 74  ? 4.079   18.984 23.790 1.00 13.90 ? 54  TRP   A H    1 
ATOM   646  H  HA   . TRP   A 1 74  ? 4.631   21.562 24.369 1.00 19.84 ? 54  TRP   A HA   1 
ATOM   647  H  HB2  . TRP   A 1 74  ? 2.399   20.329 23.442 1.00 17.75 ? 54  TRP   A HB2  1 
ATOM   648  H  HB3  . TRP   A 1 74  ? 2.048   21.259 24.684 1.00 17.75 ? 54  TRP   A HB3  1 
ATOM   649  H  HD1  . TRP   A 1 74  ? 1.409   23.638 23.929 1.00 24.51 ? 54  TRP   A HD1  1 
ATOM   650  H  HE1  . TRP   A 1 74  ? 1.967   25.148 22.139 1.00 24.59 ? 54  TRP   A HE1  1 
ATOM   651  H  HE3  . TRP   A 1 74  ? 4.625   20.849 21.490 1.00 20.80 ? 54  TRP   A HE3  1 
ATOM   652  H  HZ2  . TRP   A 1 74  ? 3.613   25.151 19.915 1.00 21.93 ? 54  TRP   A HZ2  1 
ATOM   653  H  HZ3  . TRP   A 1 74  ? 5.625   21.690 19.568 1.00 20.07 ? 54  TRP   A HZ3  1 
ATOM   654  H  HH2  . TRP   A 1 74  ? 5.121   23.810 18.797 1.00 22.21 ? 54  TRP   A HH2  1 
ATOM   655  N  N    . THR   A 1 75  ? 4.247   19.533 26.666 1.00 11.79 ? 55  THR   A N    1 
ATOM   656  C  CA   . THR   A 1 75  ? 4.081   19.279 28.091 1.00 14.50 ? 55  THR   A CA   1 
ATOM   657  C  C    . THR   A 1 75  ? 5.424   18.824 28.652 1.00 15.33 ? 55  THR   A C    1 
ATOM   658  O  O    . THR   A 1 75  ? 5.838   17.681 28.430 1.00 15.06 ? 55  THR   A O    1 
ATOM   659  C  CB   . THR   A 1 75  ? 3.006   18.217 28.321 1.00 11.54 ? 55  THR   A CB   1 
ATOM   660  O  OG1  . THR   A 1 75  ? 3.276   17.081 27.485 1.00 11.96 ? 55  THR   A OG1  1 
ATOM   661  C  CG2  . THR   A 1 75  ? 1.623   18.733 27.995 1.00 14.33 ? 55  THR   A CG2  1 
ATOM   662  H  H    . THR   A 1 75  ? 4.534   18.847 26.234 1.00 14.16 ? 55  THR   A H    1 
ATOM   663  H  HA   . THR   A 1 75  ? 3.815   20.094 28.544 1.00 17.42 ? 55  THR   A HA   1 
ATOM   664  H  HB   . THR   A 1 75  ? 3.019   17.942 29.251 1.00 13.86 ? 55  THR   A HB   1 
ATOM   665  H  HG1  . THR   A 1 75  ? 4.027   16.757 27.674 1.00 14.37 ? 55  THR   A HG1  1 
ATOM   666  H  HG21 . THR   A 1 75  ? 0.965   18.038 28.151 1.00 17.21 ? 55  THR   A HG21 1 
ATOM   667  H  HG22 . THR   A 1 75  ? 1.414   19.497 28.555 1.00 17.21 ? 55  THR   A HG22 1 
ATOM   668  H  HG23 . THR   A 1 75  ? 1.581   19.004 27.065 1.00 17.21 ? 55  THR   A HG23 1 
ATOM   669  N  N    . THR   A 1 76  ? 6.100   19.717 29.377 1.00 14.57 ? 56  THR   A N    1 
ATOM   670  C  CA   . THR   A 1 76  ? 7.432   19.432 29.890 1.00 12.39 ? 56  THR   A CA   1 
ATOM   671  C  C    . THR   A 1 76  ? 7.518   19.891 31.339 1.00 13.80 ? 56  THR   A C    1 
ATOM   672  O  O    . THR   A 1 76  ? 6.617   20.565 31.844 1.00 15.96 ? 56  THR   A O    1 
ATOM   673  C  CB   . THR   A 1 76  ? 8.520   20.158 29.099 1.00 19.49 ? 56  THR   A CB   1 
ATOM   674  O  OG1  . THR   A 1 76  ? 8.470   21.549 29.448 1.00 20.65 ? 56  THR   A OG1  1 
ATOM   675  C  CG2  . THR   A 1 76  ? 8.318   20.000 27.608 1.00 20.44 ? 56  THR   A CG2  1 
ATOM   676  H  H    . THR   A 1 76  ? 5.804   20.497 29.584 1.00 17.50 ? 56  THR   A H    1 
ATOM   677  H  HA   . THR   A 1 76  ? 7.604   18.478 29.855 1.00 14.88 ? 56  THR   A HA   1 
ATOM   678  H  HB   . THR   A 1 76  ? 9.389   19.795 29.333 1.00 23.41 ? 56  THR   A HB   1 
ATOM   679  H  HG1  . THR   A 1 76  ? 9.044   21.976 29.008 1.00 24.80 ? 56  THR   A HG1  1 
ATOM   680  H  HG21 . THR   A 1 76  ? 9.094   20.333 27.132 1.00 24.54 ? 56  THR   A HG21 1 
ATOM   681  H  HG22 . THR   A 1 76  ? 8.193   19.063 27.389 1.00 24.54 ? 56  THR   A HG22 1 
ATOM   682  H  HG23 . THR   A 1 76  ? 7.535   20.497 27.324 1.00 24.54 ? 56  THR   A HG23 1 
ATOM   683  N  N    . ASP   A 1 77  ? 8.654   19.592 31.991 1.00 15.43 ? 57  ASP   A N    1 
ATOM   684  C  CA   . ASP   A 1 77  ? 8.780   19.945 33.403 1.00 16.94 ? 57  ASP   A CA   1 
ATOM   685  C  C    . ASP   A 1 77  ? 8.817   21.457 33.600 1.00 22.27 ? 57  ASP   A C    1 
ATOM   686  O  O    . ASP   A 1 77  ? 8.390   21.952 34.649 1.00 22.05 ? 57  ASP   A O    1 
ATOM   687  C  CB   . ASP   A 1 77  ? 10.017  19.292 34.044 1.00 16.23 ? 57  ASP   A CB   1 
ATOM   688  C  CG   . ASP   A 1 77  ? 11.336  19.805 33.490 1.00 21.29 ? 57  ASP   A CG   1 
ATOM   689  O  OD1  . ASP   A 1 77  ? 11.769  20.917 33.859 1.00 29.62 ? 57  ASP   A OD1  1 
ATOM   690  O  OD2  . ASP   A 1 77  ? 11.971  19.063 32.718 1.00 20.14 ? 57  ASP   A OD2  1 
ATOM   691  H  H    . ASP   A 1 77  ? 9.339   19.200 31.649 1.00 18.53 ? 57  ASP   A H    1 
ATOM   692  H  HA   . ASP   A 1 77  ? 8.003   19.614 33.873 1.00 20.35 ? 57  ASP   A HA   1 
ATOM   693  H  HB2  . ASP   A 1 77  ? 10.006  19.471 34.997 1.00 19.49 ? 57  ASP   A HB2  1 
ATOM   694  H  HB3  . ASP   A 1 77  ? 9.982   18.335 33.888 1.00 19.49 ? 57  ASP   A HB3  1 
ATOM   695  N  N    . SER   A 1 78  ? 9.301   22.201 32.605 1.00 19.73 ? 58  SER   A N    1 
ATOM   696  C  CA   . SER   A 1 78  ? 9.436   23.642 32.735 1.00 22.20 ? 58  SER   A CA   1 
ATOM   697  C  C    . SER   A 1 78  ? 8.131   24.388 32.502 1.00 27.09 ? 58  SER   A C    1 
ATOM   698  O  O    . SER   A 1 78  ? 8.038   25.570 32.849 1.00 30.84 ? 58  SER   A O    1 
ATOM   699  C  CB   . SER   A 1 78  ? 10.469  24.161 31.736 1.00 23.50 ? 58  SER   A CB   1 
ATOM   700  O  OG   . SER   A 1 78  ? 9.904   24.191 30.435 1.00 27.85 ? 58  SER   A OG   1 
ATOM   701  H  H    . SER   A 1 78  ? 9.558   21.891 31.845 1.00 23.69 ? 58  SER   A H    1 
ATOM   702  H  HA   . SER   A 1 78  ? 9.748   23.852 33.629 1.00 26.66 ? 58  SER   A HA   1 
ATOM   703  H  HB2  . SER   A 1 78  ? 10.735  25.059 31.989 1.00 28.22 ? 58  SER   A HB2  1 
ATOM   704  H  HB3  . SER   A 1 78  ? 11.238  23.570 31.736 1.00 28.22 ? 58  SER   A HB3  1 
ATOM   705  H  HG   . SER   A 1 78  ? 9.663   23.419 30.209 1.00 33.44 ? 58  SER   A HG   1 
ATOM   706  N  N    . GLY   A 1 79  ? 7.138   23.741 31.911 1.00 23.72 ? 59  GLY   A N    1 
ATOM   707  C  CA   . GLY   A 1 79  ? 5.921   24.416 31.531 1.00 23.37 ? 59  GLY   A CA   1 
ATOM   708  C  C    . GLY   A 1 79  ? 5.980   25.102 30.188 1.00 23.93 ? 59  GLY   A C    1 
ATOM   709  O  O    . GLY   A 1 79  ? 4.966   25.660 29.748 1.00 30.17 ? 59  GLY   A O    1 
ATOM   710  H  H    . GLY   A 1 79  ? 7.149   22.903 31.719 1.00 28.49 ? 59  GLY   A H    1 
ATOM   711  H  HA2  . GLY   A 1 79  ? 5.197   23.771 31.506 1.00 28.06 ? 59  GLY   A HA2  1 
ATOM   712  H  HA3  . GLY   A 1 79  ? 5.706   25.084 32.201 1.00 28.06 ? 59  GLY   A HA3  1 
ATOM   713  N  N    . GLN   A 1 80  ? 7.127   25.089 29.528 1.00 23.37 ? 60  GLN   A N    1 
ATOM   714  C  CA   . GLN   A 1 80  ? 7.234   25.637 28.191 1.00 28.22 ? 60  GLN   A CA   1 
ATOM   715  C  C    . GLN   A 1 80  ? 7.391   24.513 27.179 1.00 21.01 ? 60  GLN   A C    1 
ATOM   716  O  O    . GLN   A 1 80  ? 8.082   23.526 27.458 1.00 21.84 ? 60  GLN   A O    1 
ATOM   717  C  CB   . GLN   A 1 80  ? 8.431   26.583 28.069 1.00 29.94 ? 60  GLN   A CB   1 
ATOM   718  C  CG   . GLN   A 1 80  ? 8.349   27.795 28.972 1.00 42.40 ? 60  GLN   A CG   1 
ATOM   719  C  CD   . GLN   A 1 80  ? 7.092   28.610 28.737 1.00 49.54 ? 60  GLN   A CD   1 
ATOM   720  O  OE1  . GLN   A 1 80  ? 6.754   28.941 27.600 1.00 55.81 ? 60  GLN   A OE1  1 
ATOM   721  N  NE2  . GLN   A 1 80  ? 6.386   28.931 29.815 1.00 51.28 ? 60  GLN   A NE2  1 
ATOM   722  H  H    . GLN   A 1 80  ? 7.863   24.767 29.835 1.00 28.06 ? 60  GLN   A H    1 
ATOM   723  H  HA   . GLN   A 1 80  ? 6.432   26.139 27.993 1.00 33.88 ? 60  GLN   A HA   1 
ATOM   724  H  HB2  . GLN   A 1 80  ? 9.238   26.097 28.299 1.00 35.95 ? 60  GLN   A HB2  1 
ATOM   725  H  HB3  . GLN   A 1 80  ? 8.487   26.899 27.154 1.00 35.95 ? 60  GLN   A HB3  1 
ATOM   726  H  HG2  . GLN   A 1 80  ? 8.349   27.502 29.897 1.00 50.90 ? 60  GLN   A HG2  1 
ATOM   727  H  HG3  . GLN   A 1 80  ? 9.114   28.367 28.804 1.00 50.90 ? 60  GLN   A HG3  1 
ATOM   728  H  HE21 . GLN   A 1 80  ? 6.652   28.681 30.594 1.00 61.56 ? 60  GLN   A HE21 1 
ATOM   729  H  HE22 . GLN   A 1 80  ? 5.664   29.392 29.735 1.00 61.56 ? 60  GLN   A HE22 1 
ATOM   730  N  N    . PRO   A 1 81  ? 6.791   24.637 25.996 1.00 20.15 ? 61  PRO   A N    1 
ATOM   731  C  CA   . PRO   A 1 81  ? 7.006   23.615 24.968 1.00 16.18 ? 61  PRO   A CA   1 
ATOM   732  C  C    . PRO   A 1 81  ? 8.468   23.518 24.560 1.00 22.13 ? 61  PRO   A C    1 
ATOM   733  O  O    . PRO   A 1 81  ? 9.228   24.487 24.626 1.00 22.42 ? 61  PRO   A O    1 
ATOM   734  C  CB   . PRO   A 1 81  ? 6.138   24.093 23.794 1.00 16.17 ? 61  PRO   A CB   1 
ATOM   735  C  CG   . PRO   A 1 81  ? 5.114   24.996 24.413 1.00 25.42 ? 61  PRO   A CG   1 
ATOM   736  C  CD   . PRO   A 1 81  ? 5.817   25.662 25.566 1.00 21.64 ? 61  PRO   A CD   1 
ATOM   737  H  HA   . PRO   A 1 81  ? 6.693   22.750 25.274 1.00 19.43 ? 61  PRO   A HA   1 
ATOM   738  H  HB2  . PRO   A 1 81  ? 6.686   24.580 23.159 1.00 19.42 ? 61  PRO   A HB2  1 
ATOM   739  H  HB3  . PRO   A 1 81  ? 5.714   23.331 23.369 1.00 19.42 ? 61  PRO   A HB3  1 
ATOM   740  H  HG2  . PRO   A 1 81  ? 4.823   25.654 23.763 1.00 30.52 ? 61  PRO   A HG2  1 
ATOM   741  H  HG3  . PRO   A 1 81  ? 4.362   24.470 24.728 1.00 30.52 ? 61  PRO   A HG3  1 
ATOM   742  H  HD2  . PRO   A 1 81  ? 6.275   26.464 25.268 1.00 25.99 ? 61  PRO   A HD2  1 
ATOM   743  H  HD3  . PRO   A 1 81  ? 5.182   25.853 26.274 1.00 25.99 ? 61  PRO   A HD3  1 
ATOM   744  N  N    . ILE   A 1 82  ? 8.856   22.325 24.136 1.00 15.53 ? 62  ILE   A N    1 
ATOM   745  C  CA   . ILE   A 1 82  ? 10.097  22.106 23.408 1.00 15.22 ? 62  ILE   A CA   1 
ATOM   746  C  C    . ILE   A 1 82  ? 9.695   21.990 21.945 1.00 20.13 ? 62  ILE   A C    1 
ATOM   747  O  O    . ILE   A 1 82  ? 9.269   20.924 21.485 1.00 17.55 ? 62  ILE   A O    1 
ATOM   748  C  CB   . ILE   A 1 82  ? 10.854  20.875 23.920 1.00 20.30 ? 62  ILE   A CB   1 
ATOM   749  C  CG1  . ILE   A 1 82  ? 11.283  21.117 25.369 1.00 22.10 ? 62  ILE   A CG1  1 
ATOM   750  C  CG2  . ILE   A 1 82  ? 12.093  20.608 23.056 1.00 24.94 ? 62  ILE   A CG2  1 
ATOM   751  C  CD1  . ILE   A 1 82  ? 11.800  19.884 26.080 1.00 30.21 ? 62  ILE   A CD1  1 
ATOM   752  H  H    . ILE   A 1 82  ? 8.403   21.605 24.262 1.00 18.65 ? 62  ILE   A H    1 
ATOM   753  H  HA   . ILE   A 1 82  ? 10.672  22.880 23.507 1.00 18.29 ? 62  ILE   A HA   1 
ATOM   754  H  HB   . ILE   A 1 82  ? 10.268  20.103 23.885 1.00 24.38 ? 62  ILE   A HB   1 
ATOM   755  H  HG12 . ILE   A 1 82  ? 11.993  21.778 25.375 1.00 26.54 ? 62  ILE   A HG12 1 
ATOM   756  H  HG13 . ILE   A 1 82  ? 10.524  21.452 25.870 1.00 26.54 ? 62  ILE   A HG13 1 
ATOM   757  H  HG21 . ILE   A 1 82  ? 12.607  19.888 23.452 1.00 29.94 ? 62  ILE   A HG21 1 
ATOM   758  H  HG22 . ILE   A 1 82  ? 11.810  20.355 22.163 1.00 29.94 ? 62  ILE   A HG22 1 
ATOM   759  H  HG23 . ILE   A 1 82  ? 12.630  21.415 23.018 1.00 29.94 ? 62  ILE   A HG23 1 
ATOM   760  H  HD11 . ILE   A 1 82  ? 11.922  20.090 27.020 1.00 36.26 ? 62  ILE   A HD11 1 
ATOM   761  H  HD12 . ILE   A 1 82  ? 11.153  19.168 25.979 1.00 36.26 ? 62  ILE   A HD12 1 
ATOM   762  H  HD13 . ILE   A 1 82  ? 12.647  19.622 25.686 1.00 36.26 ? 62  ILE   A HD13 1 
ATOM   763  N  N    . ALA   A 1 83  ? 9.777   23.107 21.231 1.00 17.96 ? 63  ALA   A N    1 
ATOM   764  C  CA   . ALA   A 1 83  ? 9.309   23.207 19.858 1.00 18.65 ? 63  ALA   A CA   1 
ATOM   765  C  C    . ALA   A 1 83  ? 10.497  23.181 18.907 1.00 22.61 ? 63  ALA   A C    1 
ATOM   766  O  O    . ALA   A 1 83  ? 11.488  23.884 19.123 1.00 22.54 ? 63  ALA   A O    1 
ATOM   767  C  CB   . ALA   A 1 83  ? 8.500   24.492 19.666 1.00 24.32 ? 63  ALA   A CB   1 
ATOM   768  H  H    . ALA   A 1 83  ? 10.110  23.841 21.531 1.00 21.57 ? 63  ALA   A H    1 
ATOM   769  H  HA   . ALA   A 1 83  ? 8.736   22.451 19.654 1.00 22.39 ? 63  ALA   A HA   1 
ATOM   770  H  HB1  . ALA   A 1 83  ? 8.198   24.540 18.746 1.00 29.20 ? 63  ALA   A HB1  1 
ATOM   771  H  HB2  . ALA   A 1 83  ? 7.737   24.477 20.265 1.00 29.20 ? 63  ALA   A HB2  1 
ATOM   772  H  HB3  . ALA   A 1 83  ? 9.065   25.254 19.869 1.00 29.20 ? 63  ALA   A HB3  1 
ATOM   773  N  N    . ILE   A 1 84  ? 10.386  22.373 17.856 1.00 16.66 ? 64  ILE   A N    1 
ATOM   774  C  CA   . ILE   A 1 84  ? 11.410  22.235 16.827 1.00 19.16 ? 64  ILE   A CA   1 
ATOM   775  C  C    . ILE   A 1 84  ? 10.895  22.966 15.595 1.00 20.04 ? 64  ILE   A C    1 
ATOM   776  O  O    . ILE   A 1 84  ? 9.868   22.576 15.029 1.00 17.28 ? 64  ILE   A O    1 
ATOM   777  C  CB   . ILE   A 1 84  ? 11.690  20.760 16.502 1.00 21.20 ? 64  ILE   A CB   1 
ATOM   778  C  CG1  . ILE   A 1 84  ? 11.809  19.927 17.783 1.00 32.85 ? 64  ILE   A CG1  1 
ATOM   779  C  CG2  . ILE   A 1 84  ? 12.936  20.638 15.641 1.00 21.60 ? 64  ILE   A CG2  1 
ATOM   780  C  CD1  . ILE   A 1 84  ? 12.980  20.281 18.651 1.00 32.65 ? 64  ILE   A CD1  1 
ATOM   781  H  H    . ILE   A 1 84  ? 9.699   21.876 17.714 1.00 20.01 ? 64  ILE   A H    1 
ATOM   782  H  HA   . ILE   A 1 84  ? 12.234  22.654 17.120 1.00 23.01 ? 64  ILE   A HA   1 
ATOM   783  H  HB   . ILE   A 1 84  ? 10.939  20.419 15.992 1.00 25.46 ? 64  ILE   A HB   1 
ATOM   784  H  HG12 . ILE   A 1 84  ? 11.003  20.034 18.312 1.00 39.43 ? 64  ILE   A HG12 1 
ATOM   785  H  HG13 . ILE   A 1 84  ? 11.907  18.995 17.532 1.00 39.43 ? 64  ILE   A HG13 1 
ATOM   786  H  HG21 . ILE   A 1 84  ? 13.152  19.699 15.530 1.00 25.94 ? 64  ILE   A HG21 1 
ATOM   787  H  HG22 . ILE   A 1 84  ? 12.763  21.042 14.776 1.00 25.94 ? 64  ILE   A HG22 1 
ATOM   788  H  HG23 . ILE   A 1 84  ? 13.670  21.096 16.079 1.00 25.94 ? 64  ILE   A HG23 1 
ATOM   789  H  HD11 . ILE   A 1 84  ? 12.937  19.755 19.465 1.00 39.20 ? 64  ILE   A HD11 1 
ATOM   790  H  HD12 . ILE   A 1 84  ? 13.801  20.083 18.174 1.00 39.20 ? 64  ILE   A HD12 1 
ATOM   791  H  HD13 . ILE   A 1 84  ? 12.941  21.226 18.866 1.00 39.20 ? 64  ILE   A HD13 1 
ATOM   792  N  N    . ARG   A 1 85  ? 11.608  24.005 15.163 0.85 19.24 ? 65  ARG   A N    1 
ATOM   793  C  CA   . ARG   A 1 85  ? 11.095  24.934 14.161 0.85 13.48 ? 65  ARG   A CA   1 
ATOM   794  C  C    . ARG   A 1 85  ? 11.823  24.753 12.838 0.85 20.53 ? 65  ARG   A C    1 
ATOM   795  O  O    . ARG   A 1 85  ? 13.033  24.988 12.745 0.85 18.18 ? 65  ARG   A O    1 
ATOM   796  C  CB   . ARG   A 1 85  ? 11.218  26.375 14.660 0.85 24.80 ? 65  ARG   A CB   1 
ATOM   797  C  CG   . ARG   A 1 85  ? 10.421  26.621 15.936 0.85 26.29 ? 65  ARG   A CG   1 
ATOM   798  C  CD   . ARG   A 1 85  ? 10.622  28.016 16.512 0.85 45.21 ? 65  ARG   A CD   1 
ATOM   799  N  NE   . ARG   A 1 85  ? 9.900   28.183 17.769 0.85 43.43 ? 65  ARG   A NE   1 
ATOM   800  C  CZ   . ARG   A 1 85  ? 8.597   28.417 17.864 0.85 50.99 ? 65  ARG   A CZ   1 
ATOM   801  N  NH1  . ARG   A 1 85  ? 7.834   28.522 16.789 0.85 37.53 ? 65  ARG   A NH1  1 
ATOM   802  N  NH2  . ARG   A 1 85  ? 8.046   28.544 19.067 0.85 63.67 ? 65  ARG   A NH2  1 
ATOM   803  H  H    . ARG   A 1 85  ? 12.400  24.194 15.439 0.85 23.11 ? 65  ARG   A H    1 
ATOM   804  H  HA   . ARG   A 1 85  ? 10.155  24.751 14.011 0.85 16.19 ? 65  ARG   A HA   1 
ATOM   805  H  HB2  . ARG   A 1 85  ? 12.150  26.567 14.846 0.85 29.77 ? 65  ARG   A HB2  1 
ATOM   806  H  HB3  . ARG   A 1 85  ? 10.885  26.977 13.976 0.85 29.77 ? 65  ARG   A HB3  1 
ATOM   807  H  HG2  . ARG   A 1 85  ? 9.477   26.511 15.743 0.85 31.56 ? 65  ARG   A HG2  1 
ATOM   808  H  HG3  . ARG   A 1 85  ? 10.697  25.979 16.609 0.85 31.56 ? 65  ARG   A HG3  1 
ATOM   809  H  HD2  . ARG   A 1 85  ? 11.566  28.156 16.685 0.85 54.27 ? 65  ARG   A HD2  1 
ATOM   810  H  HD3  . ARG   A 1 85  ? 10.297  28.677 15.882 0.85 54.27 ? 65  ARG   A HD3  1 
ATOM   811  H  HE   . ARG   A 1 85  ? 10.350  28.126 18.499 0.85 52.14 ? 65  ARG   A HE   1 
ATOM   812  H  HH11 . ARG   A 1 85  ? 8.177   28.441 16.005 0.85 45.05 ? 65  ARG   A HH11 1 
ATOM   813  H  HH12 . ARG   A 1 85  ? 6.992   28.673 16.874 0.85 45.05 ? 65  ARG   A HH12 1 
ATOM   814  H  HH21 . ARG   A 1 85  ? 8.533   28.477 19.772 0.85 76.42 ? 65  ARG   A HH21 1 
ATOM   815  H  HH22 . ARG   A 1 85  ? 7.203   28.696 19.140 0.85 76.42 ? 65  ARG   A HH22 1 
ATOM   816  N  N    . GLY   A 1 86  ? 11.080  24.344 11.821 1.00 21.14 ? 66  GLY   A N    1 
ATOM   817  C  CA   . GLY   A 1 86  ? 11.649  24.224 10.502 1.00 24.25 ? 66  GLY   A CA   1 
ATOM   818  C  C    . GLY   A 1 86  ? 11.934  22.791 10.123 1.00 24.94 ? 66  GLY   A C    1 
ATOM   819  O  O    . GLY   A 1 86  ? 12.411  21.980 10.923 1.00 19.24 ? 66  GLY   A O    1 
ATOM   820  H  H    . GLY   A 1 86  ? 10.248  24.132 11.873 1.00 25.39 ? 66  GLY   A H    1 
ATOM   821  H  HA2  . GLY   A 1 86  ? 11.030  24.592 9.853  1.00 29.12 ? 66  GLY   A HA2  1 
ATOM   822  H  HA3  . GLY   A 1 86  ? 12.475  24.728 10.453 1.00 29.12 ? 66  GLY   A HA3  1 
ATOM   823  N  N    . ARG   A 1 87  ? 11.648  22.475 8.872  1.00 26.03 ? 67  ARG   A N    1 
ATOM   824  C  CA   . ARG   A 1 87  ? 11.822  21.111 8.408  1.00 24.98 ? 67  ARG   A CA   1 
ATOM   825  C  C    . ARG   A 1 87  ? 13.252  20.626 8.615  1.00 25.14 ? 67  ARG   A C    1 
ATOM   826  O  O    . ARG   A 1 87  ? 13.471  19.453 8.938  1.00 29.29 ? 67  ARG   A O    1 
ATOM   827  C  CB   . ARG   A 1 87  ? 11.402  21.048 6.948  1.00 23.82 ? 67  ARG   A CB   1 
ATOM   828  C  CG   . ARG   A 1 87  ? 11.246  19.675 6.425  1.00 23.09 ? 67  ARG   A CG   1 
ATOM   829  C  CD   . ARG   A 1 87  ? 11.222  19.762 4.941  1.00 29.73 ? 67  ARG   A CD   1 
ATOM   830  N  NE   . ARG   A 1 87  ? 9.900   19.449 4.417  1.00 29.25 ? 67  ARG   A NE   1 
ATOM   831  C  CZ   . ARG   A 1 87  ? 9.526   19.689 3.169  1.00 34.51 ? 67  ARG   A CZ   1 
ATOM   832  N  NH1  . ARG   A 1 87  ? 10.315  20.338 2.330  1.00 32.96 ? 67  ARG   A NH1  1 
ATOM   833  N  NH2  . ARG   A 1 87  ? 8.340   19.257 2.752  1.00 22.02 ? 67  ARG   A NH2  1 
ATOM   834  H  H    . ARG   A 1 87  ? 11.355  23.024 8.278  1.00 31.25 ? 67  ARG   A H    1 
ATOM   835  H  HA   . ARG   A 1 87  ? 11.234  20.528 8.913  1.00 29.99 ? 67  ARG   A HA   1 
ATOM   836  H  HB2  . ARG   A 1 87  ? 10.552  21.504 6.846  1.00 28.60 ? 67  ARG   A HB2  1 
ATOM   837  H  HB3  . ARG   A 1 87  ? 12.083  21.500 6.426  1.00 28.60 ? 67  ARG   A HB3  1 
ATOM   838  H  HG2  . ARG   A 1 87  ? 11.998  19.128 6.698  1.00 27.72 ? 67  ARG   A HG2  1 
ATOM   839  H  HG3  . ARG   A 1 87  ? 10.409  19.297 6.734  1.00 27.72 ? 67  ARG   A HG3  1 
ATOM   840  H  HD2  . ARG   A 1 87  ? 11.452  20.658 4.653  1.00 35.69 ? 67  ARG   A HD2  1 
ATOM   841  H  HD3  . ARG   A 1 87  ? 11.851  19.121 4.575  1.00 35.69 ? 67  ARG   A HD3  1 
ATOM   842  H  HE   . ARG   A 1 87  ? 9.375   18.977 4.908  1.00 35.12 ? 67  ARG   A HE   1 
ATOM   843  H  HH11 . ARG   A 1 87  ? 11.086  20.617 2.587  1.00 39.57 ? 67  ARG   A HH11 1 
ATOM   844  H  HH12 . ARG   A 1 87  ? 10.054  20.485 1.524  1.00 39.57 ? 67  ARG   A HH12 1 
ATOM   845  H  HH21 . ARG   A 1 87  ? 7.821   18.836 3.293  1.00 26.44 ? 67  ARG   A HH21 1 
ATOM   846  H  HH22 . ARG   A 1 87  ? 8.085   19.412 1.946  1.00 26.44 ? 67  ARG   A HH22 1 
ATOM   847  N  N    . GLU   A 1 88  ? 14.241  21.510 8.460  1.00 32.48 ? 68  GLU   A N    1 
ATOM   848  C  CA   . GLU   A 1 88  ? 15.628  21.076 8.620  1.00 33.10 ? 68  GLU   A CA   1 
ATOM   849  C  C    . GLU   A 1 88  ? 15.940  20.739 10.075 1.00 27.61 ? 68  GLU   A C    1 
ATOM   850  O  O    . GLU   A 1 88  ? 16.591  19.726 10.357 1.00 30.96 ? 68  GLU   A O    1 
ATOM   851  C  CB   . GLU   A 1 88  ? 16.586  22.149 8.101  1.00 46.99 ? 68  GLU   A CB   1 
ATOM   852  H  H    . GLU   A 1 88  ? 14.139  22.342 8.268  1.00 38.99 ? 68  GLU   A H    1 
ATOM   853  H  HA   . GLU   A 1 88  ? 15.767  20.274 8.093  1.00 39.74 ? 68  GLU   A HA   1 
ATOM   854  N  N    . LYS   A 1 89  ? 15.493  21.574 11.014 1.00 26.21 ? 69  LYS   A N    1 
ATOM   855  C  CA   . LYS   A 1 89  ? 15.678  21.244 12.423 1.00 24.43 ? 69  LYS   A CA   1 
ATOM   856  C  C    . LYS   A 1 89  ? 14.885  20.001 12.815 1.00 23.53 ? 69  LYS   A C    1 
ATOM   857  O  O    . LYS   A 1 89  ? 15.320  19.240 13.686 1.00 22.85 ? 69  LYS   A O    1 
ATOM   858  C  CB   . LYS   A 1 89  ? 15.287  22.436 13.298 1.00 27.95 ? 69  LYS   A CB   1 
ATOM   859  C  CG   . LYS   A 1 89  ? 16.264  23.604 13.216 1.00 38.76 ? 69  LYS   A CG   1 
ATOM   860  H  H    . LYS   A 1 89  ? 15.090  22.319 10.865 1.00 31.47 ? 69  LYS   A H    1 
ATOM   861  H  HA   . LYS   A 1 89  ? 16.617  21.057 12.579 1.00 29.34 ? 69  LYS   A HA   1 
ATOM   862  H  HB2  . LYS   A 1 89  ? 14.416  22.758 13.017 1.00 33.55 ? 69  LYS   A HB2  1 
ATOM   863  H  HB3  . LYS   A 1 89  ? 15.248  22.146 14.223 1.00 33.55 ? 69  LYS   A HB3  1 
ATOM   864  N  N    . LEU   A 1 90  ? 13.731  19.772 12.185 1.00 23.03 ? 70  LEU   A N    1 
ATOM   865  C  CA   . LEU   A 1 90  ? 12.971  18.558 12.478 1.00 17.68 ? 70  LEU   A CA   1 
ATOM   866  C  C    . LEU   A 1 90  ? 13.742  17.317 12.048 1.00 20.38 ? 70  LEU   A C    1 
ATOM   867  O  O    . LEU   A 1 90  ? 13.731  16.295 12.745 1.00 19.44 ? 70  LEU   A O    1 
ATOM   868  C  CB   . LEU   A 1 90  ? 11.606  18.611 11.798 1.00 15.97 ? 70  LEU   A CB   1 
ATOM   869  C  CG   . LEU   A 1 90  ? 10.611  19.595 12.417 1.00 19.07 ? 70  LEU   A CG   1 
ATOM   870  C  CD1  . LEU   A 1 90  ? 9.484   19.915 11.457 1.00 21.70 ? 70  LEU   A CD1  1 
ATOM   871  C  CD2  . LEU   A 1 90  ? 10.077  18.997 13.715 1.00 20.34 ? 70  LEU   A CD2  1 
ATOM   872  H  H    . LEU   A 1 90  ? 13.375  20.290 11.598 1.00 27.66 ? 70  LEU   A H    1 
ATOM   873  H  HA   . LEU   A 1 90  ? 12.829  18.501 13.435 1.00 21.23 ? 70  LEU   A HA   1 
ATOM   874  H  HB2  . LEU   A 1 90  ? 11.733  18.868 10.871 1.00 19.19 ? 70  LEU   A HB2  1 
ATOM   875  H  HB3  . LEU   A 1 90  ? 11.207  17.728 11.838 1.00 19.19 ? 70  LEU   A HB3  1 
ATOM   876  H  HG   . LEU   A 1 90  ? 11.071  20.422 12.631 1.00 22.90 ? 70  LEU   A HG   1 
ATOM   877  H  HD11 . LEU   A 1 90  ? 8.836   20.478 11.909 1.00 26.06 ? 70  LEU   A HD11 1 
ATOM   878  H  HD12 . LEU   A 1 90  ? 9.847   20.381 10.688 1.00 26.06 ? 70  LEU   A HD12 1 
ATOM   879  H  HD13 . LEU   A 1 90  ? 9.064   19.087 11.176 1.00 26.06 ? 70  LEU   A HD13 1 
ATOM   880  H  HD21 . LEU   A 1 90  ? 9.439   19.614 14.107 1.00 24.42 ? 70  LEU   A HD21 1 
ATOM   881  H  HD22 . LEU   A 1 90  ? 9.642   18.153 13.518 1.00 24.42 ? 70  LEU   A HD22 1 
ATOM   882  H  HD23 . LEU   A 1 90  ? 10.816  18.853 14.326 1.00 24.42 ? 70  LEU   A HD23 1 
ATOM   883  N  N    . GLY   A 1 91  ? 14.429  17.390 10.907 1.00 23.33 ? 71  GLY   A N    1 
ATOM   884  C  CA   . GLY   A 1 91  ? 15.241  16.267 10.471 1.00 22.66 ? 71  GLY   A CA   1 
ATOM   885  C  C    . GLY   A 1 91  ? 16.404  15.999 11.404 1.00 24.49 ? 71  GLY   A C    1 
ATOM   886  O  O    . GLY   A 1 91  ? 16.725  14.842 11.693 1.00 22.78 ? 71  GLY   A O    1 
ATOM   887  H  H    . GLY   A 1 91  ? 14.439  18.069 10.379 1.00 28.02 ? 71  GLY   A H    1 
ATOM   888  H  HA2  . GLY   A 1 91  ? 14.692  15.469 10.427 1.00 27.21 ? 71  GLY   A HA2  1 
ATOM   889  H  HA3  . GLY   A 1 91  ? 15.593  16.447 9.585  1.00 27.21 ? 71  GLY   A HA3  1 
ATOM   890  N  N    . GLU   A 1 92  ? 17.043  17.061 11.899 1.00 23.92 ? 72  GLU   A N    1 
ATOM   891  C  CA   . GLU   A 1 92  ? 18.125  16.892 12.861 1.00 28.24 ? 72  GLU   A CA   1 
ATOM   892  C  C    . GLU   A 1 92  ? 17.618  16.270 14.155 1.00 26.77 ? 72  GLU   A C    1 
ATOM   893  O  O    . GLU   A 1 92  ? 18.287  15.413 14.742 1.00 28.90 ? 72  GLU   A O    1 
ATOM   894  C  CB   . GLU   A 1 92  ? 18.791  18.237 13.144 1.00 34.20 ? 72  GLU   A CB   1 
ATOM   895  C  CG   . GLU   A 1 92  ? 19.500  18.839 11.949 1.00 42.98 ? 72  GLU   A CG   1 
ATOM   896  C  CD   . GLU   A 1 92  ? 20.047  20.224 12.234 1.00 62.53 ? 72  GLU   A CD   1 
ATOM   897  O  OE1  . GLU   A 1 92  ? 19.944  20.681 13.394 1.00 57.04 ? 72  GLU   A OE1  1 
ATOM   898  O  OE2  . GLU   A 1 92  ? 20.575  20.856 11.295 1.00 54.61 ? 72  GLU   A OE2  1 
ATOM   899  H  H    . GLU   A 1 92  ? 16.870  17.878 11.695 1.00 28.72 ? 72  GLU   A H    1 
ATOM   900  H  HA   . GLU   A 1 92  ? 18.794  16.299 12.484 1.00 33.91 ? 72  GLU   A HA   1 
ATOM   901  H  HB2  . GLU   A 1 92  ? 18.112  18.866 13.433 1.00 41.06 ? 72  GLU   A HB2  1 
ATOM   902  H  HB3  . GLU   A 1 92  ? 19.448  18.118 13.848 1.00 41.06 ? 72  GLU   A HB3  1 
ATOM   903  H  HG2  . GLU   A 1 92  ? 20.243  18.267 11.701 1.00 51.59 ? 72  GLU   A HG2  1 
ATOM   904  H  HG3  . GLU   A 1 92  ? 18.874  18.909 11.211 1.00 51.59 ? 72  GLU   A HG3  1 
ATOM   905  N  N    . HIS   A 1 93  ? 16.432  16.683 14.613 1.00 20.03 ? 73  HIS   A N    1 
ATOM   906  C  CA   . HIS   A 1 93  ? 15.895  16.112 15.842 1.00 22.99 ? 73  HIS   A CA   1 
ATOM   907  C  C    . HIS   A 1 93  ? 15.640  14.617 15.699 1.00 22.87 ? 73  HIS   A C    1 
ATOM   908  O  O    . HIS   A 1 93  ? 15.808  13.864 16.665 1.00 19.27 ? 73  HIS   A O    1 
ATOM   909  C  CB   . HIS   A 1 93  ? 14.604  16.824 16.247 1.00 24.03 ? 73  HIS   A CB   1 
ATOM   910  C  CG   . HIS   A 1 93  ? 13.898  16.177 17.398 1.00 20.61 ? 73  HIS   A CG   1 
ATOM   911  N  ND1  . HIS   A 1 93  ? 14.243  16.414 18.712 1.00 26.87 ? 73  HIS   A ND1  1 
ATOM   912  C  CD2  . HIS   A 1 93  ? 12.883  15.282 17.431 1.00 26.53 ? 73  HIS   A CD2  1 
ATOM   913  C  CE1  . HIS   A 1 93  ? 13.460  15.704 19.504 1.00 27.45 ? 73  HIS   A CE1  1 
ATOM   914  N  NE2  . HIS   A 1 93  ? 12.631  15.004 18.751 1.00 28.41 ? 73  HIS   A NE2  1 
ATOM   915  H  H    . HIS   A 1 93  ? 15.934  17.276 14.240 1.00 24.06 ? 73  HIS   A H    1 
ATOM   916  H  HA   . HIS   A 1 93  ? 16.541  16.237 16.555 1.00 27.60 ? 73  HIS   A HA   1 
ATOM   917  H  HB2  . HIS   A 1 93  ? 14.816  17.735 16.503 1.00 28.85 ? 73  HIS   A HB2  1 
ATOM   918  H  HB3  . HIS   A 1 93  ? 13.997  16.827 15.490 1.00 28.85 ? 73  HIS   A HB3  1 
ATOM   919  H  HD1  . HIS   A 1 93  ? 14.864  16.947 18.975 1.00 32.27 ? 73  HIS   A HD1  1 
ATOM   920  H  HD2  . HIS   A 1 93  ? 12.439  14.924 16.697 1.00 31.85 ? 73  HIS   A HD2  1 
ATOM   921  H  HE1  . HIS   A 1 93  ? 13.492  15.693 20.433 1.00 32.96 ? 73  HIS   A HE1  1 
ATOM   922  N  N    . ALA   A 1 94  ? 15.232  14.167 14.511 1.00 21.61 ? 74  ALA   A N    1 
ATOM   923  C  CA   . ALA   A 1 94  ? 14.969  12.745 14.315 1.00 22.73 ? 74  ALA   A CA   1 
ATOM   924  C  C    . ALA   A 1 94  ? 16.213  11.911 14.585 1.00 21.95 ? 74  ALA   A C    1 
ATOM   925  O  O    . ALA   A 1 94  ? 16.112  10.780 15.079 1.00 18.45 ? 74  ALA   A O    1 
ATOM   926  C  CB   . ALA   A 1 94  ? 14.455  12.500 12.896 1.00 24.90 ? 74  ALA   A CB   1 
ATOM   927  H  H    . ALA   A 1 94  ? 15.102  14.656 13.816 1.00 25.95 ? 74  ALA   A H    1 
ATOM   928  H  HA   . ALA   A 1 94  ? 14.279  12.463 14.936 1.00 27.29 ? 74  ALA   A HA   1 
ATOM   929  H  HB1  . ALA   A 1 94  ? 14.285  11.552 12.781 1.00 29.90 ? 74  ALA   A HB1  1 
ATOM   930  H  HB2  . ALA   A 1 94  ? 13.635  13.001 12.767 1.00 29.90 ? 74  ALA   A HB2  1 
ATOM   931  H  HB3  . ALA   A 1 94  ? 15.127  12.795 12.262 1.00 29.90 ? 74  ALA   A HB3  1 
ATOM   932  N  N    . VAL   A 1 95  ? 17.392  12.448 14.275 1.00 23.61 ? 75  VAL   A N    1 
ATOM   933  C  CA   . VAL   A 1 95  ? 18.630  11.763 14.627 1.00 27.40 ? 75  VAL   A CA   1 
ATOM   934  C  C    . VAL   A 1 95  ? 18.704  11.553 16.134 1.00 21.64 ? 75  VAL   A C    1 
ATOM   935  O  O    . VAL   A 1 95  ? 19.021  10.457 16.613 1.00 26.72 ? 75  VAL   A O    1 
ATOM   936  C  CB   . VAL   A 1 95  ? 19.844  12.552 14.108 1.00 33.12 ? 75  VAL   A CB   1 
ATOM   937  C  CG1  . VAL   A 1 95  ? 21.122  11.926 14.622 1.00 32.90 ? 75  VAL   A CG1  1 
ATOM   938  C  CG2  . VAL   A 1 95  ? 19.825  12.603 12.590 1.00 34.90 ? 75  VAL   A CG2  1 
ATOM   939  H  H    . VAL   A 1 95  ? 17.500  13.197 13.867 1.00 28.35 ? 75  VAL   A H    1 
ATOM   940  H  HA   . VAL   A 1 95  ? 18.638  10.890 14.203 1.00 32.90 ? 75  VAL   A HA   1 
ATOM   941  H  HB   . VAL   A 1 95  ? 19.799  13.462 14.441 1.00 39.77 ? 75  VAL   A HB   1 
ATOM   942  H  HG11 . VAL   A 1 95  ? 21.866  12.385 14.209 1.00 39.50 ? 75  VAL   A HG11 1 
ATOM   943  H  HG12 . VAL   A 1 95  ? 21.174  12.030 15.584 1.00 39.50 ? 75  VAL   A HG12 1 
ATOM   944  H  HG13 . VAL   A 1 95  ? 21.135  10.986 14.384 1.00 39.50 ? 75  VAL   A HG13 1 
ATOM   945  H  HG21 . VAL   A 1 95  ? 20.616  13.071 12.280 1.00 41.90 ? 75  VAL   A HG21 1 
ATOM   946  H  HG22 . VAL   A 1 95  ? 19.820  11.697 12.244 1.00 41.90 ? 75  VAL   A HG22 1 
ATOM   947  H  HG23 . VAL   A 1 95  ? 19.028  13.073 12.299 1.00 41.90 ? 75  VAL   A HG23 1 
ATOM   948  N  N    . TRP   A 1 96  ? 18.426  12.608 16.905 1.00 20.88 ? 76  TRP   A N    1 
ATOM   949  C  CA   . TRP   A 1 96  ? 18.440  12.467 18.355 1.00 26.30 ? 76  TRP   A CA   1 
ATOM   950  C  C    . TRP   A 1 96  ? 17.332  11.530 18.813 1.00 33.82 ? 76  TRP   A C    1 
ATOM   951  O  O    . TRP   A 1 96  ? 17.539  10.704 19.710 1.00 35.19 ? 76  TRP   A O    1 
ATOM   952  C  CB   . TRP   A 1 96  ? 18.294  13.829 19.030 1.00 22.14 ? 76  TRP   A CB   1 
ATOM   953  H  H    . TRP   A 1 96  ? 18.231  13.395 16.618 1.00 25.07 ? 76  TRP   A H    1 
ATOM   954  H  HA   . TRP   A 1 96  ? 19.289  12.085 18.628 1.00 31.58 ? 76  TRP   A HA   1 
ATOM   955  N  N    . SER   A 1 97  ? 16.151  11.646 18.198 1.00 25.26 ? 77  SER   A N    1 
ATOM   956  C  CA   . SER   A 1 97  ? 15.014  10.807 18.563 1.00 26.25 ? 77  SER   A CA   1 
ATOM   957  C  C    . SER   A 1 97  ? 15.365  9.328  18.459 1.00 21.46 ? 77  SER   A C    1 
ATOM   958  O  O    . SER   A 1 97  ? 15.056  8.544  19.364 1.00 28.63 ? 77  SER   A O    1 
ATOM   959  C  CB   . SER   A 1 97  ? 13.825  11.159 17.663 1.00 24.16 ? 77  SER   A CB   1 
ATOM   960  O  OG   . SER   A 1 97  ? 12.618  10.550 18.085 1.00 27.12 ? 77  SER   A OG   1 
ATOM   961  H  H    . SER   A 1 97  ? 15.986  12.205 17.566 1.00 30.33 ? 77  SER   A H    1 
ATOM   962  H  HA   . SER   A 1 97  ? 14.763  10.994 19.481 1.00 31.52 ? 77  SER   A HA   1 
ATOM   963  H  HB2  . SER   A 1 97  ? 13.705  12.122 17.671 1.00 29.01 ? 77  SER   A HB2  1 
ATOM   964  H  HB3  . SER   A 1 97  ? 14.022  10.863 16.761 1.00 29.01 ? 77  SER   A HB3  1 
ATOM   965  H  HG   . SER   A 1 97  ? 12.427  10.799 18.864 1.00 32.56 ? 77  SER   A HG   1 
ATOM   966  N  N    . LEU   A 1 98  ? 16.033  8.933  17.373 1.00 23.22 ? 78  LEU   A N    1 
ATOM   967  C  CA   . LEU   A 1 98  ? 16.375  7.530  17.177 1.00 27.53 ? 78  LEU   A CA   1 
ATOM   968  C  C    . LEU   A 1 98  ? 17.435  7.046  18.153 1.00 30.81 ? 78  LEU   A C    1 
ATOM   969  O  O    . LEU   A 1 98  ? 17.546  5.838  18.382 1.00 33.34 ? 78  LEU   A O    1 
ATOM   970  C  CB   . LEU   A 1 98  ? 16.856  7.311  15.747 0.74 25.37 ? 78  LEU   A CB   1 
ATOM   971  C  CG   . LEU   A 1 98  ? 15.754  7.019  14.734 1.00 33.12 ? 78  LEU   A CG   1 
ATOM   972  C  CD1  . LEU   A 1 98  ? 16.293  7.240  13.341 1.00 38.50 ? 78  LEU   A CD1  1 
ATOM   973  C  CD2  . LEU   A 1 98  ? 15.244  5.604  14.898 0.73 25.48 ? 78  LEU   A CD2  1 
ATOM   974  H  H    . LEU   A 1 98  ? 16.296  9.455  16.743 1.00 27.88 ? 78  LEU   A H    1 
ATOM   975  H  HA   . LEU   A 1 98  ? 15.579  6.993  17.312 1.00 33.05 ? 78  LEU   A HA   1 
ATOM   976  H  HB2  . LEU   A 1 98  ? 17.322  8.109  15.453 0.73 30.46 ? 78  LEU   A HB2  1 
ATOM   977  H  HB3  . LEU   A 1 98  ? 17.467  6.557  15.740 0.73 30.46 ? 78  LEU   A HB3  1 
ATOM   978  H  HG   . LEU   A 1 98  ? 15.014  7.630  14.877 1.00 39.76 ? 78  LEU   A HG   1 
ATOM   979  H  HD11 . LEU   A 1 98  ? 15.570  7.139  12.702 1.00 46.22 ? 78  LEU   A HD11 1 
ATOM   980  H  HD12 . LEU   A 1 98  ? 16.659  8.135  13.290 1.00 46.22 ? 78  LEU   A HD12 1 
ATOM   981  H  HD13 . LEU   A 1 98  ? 16.988  6.587  13.163 1.00 46.22 ? 78  LEU   A HD13 1 
ATOM   982  H  HD21 . LEU   A 1 98  ? 14.584  5.426  14.210 0.70 30.59 ? 78  LEU   A HD21 1 
ATOM   983  H  HD22 . LEU   A 1 98  ? 15.988  4.988  14.810 0.74 30.59 ? 78  LEU   A HD22 1 
ATOM   984  H  HD23 . LEU   A 1 98  ? 14.841  5.512  15.775 0.74 30.59 ? 78  LEU   A HD23 1 
ATOM   985  N  N    . GLN   A 1 99  ? 18.224  7.956  18.714 1.00 27.42 ? 79  GLN   A N    1 
ATOM   986  C  CA   . GLN   A 1 99  ? 19.182  7.573  19.742 1.00 26.69 ? 79  GLN   A CA   1 
ATOM   987  C  C    . GLN   A 1 99  ? 18.493  7.416  21.090 1.00 24.35 ? 79  GLN   A C    1 
ATOM   988  O  O    . GLN   A 1 99  ? 18.685  6.413  21.783 1.00 29.00 ? 79  GLN   A O    1 
ATOM   989  C  CB   . GLN   A 1 99  ? 20.297  8.615  19.823 1.00 35.21 ? 79  GLN   A CB   1 
ATOM   990  C  CG   . GLN   A 1 99  ? 21.308  8.361  20.919 1.00 43.18 ? 79  GLN   A CG   1 
ATOM   991  C  CD   . GLN   A 1 99  ? 22.595  9.143  20.715 1.00 66.62 ? 79  GLN   A CD   1 
ATOM   992  O  OE1  . GLN   A 1 99  ? 22.581  10.369 20.587 1.00 55.29 ? 79  GLN   A OE1  1 
ATOM   993  N  NE2  . GLN   A 1 99  ? 23.715  8.431  20.672 1.00 59.81 ? 79  GLN   A NE2  1 
ATOM   994  H  H    . GLN   A 1 99  ? 18.225  8.794  18.519 1.00 32.92 ? 79  GLN   A H    1 
ATOM   995  H  HA   . GLN   A 1 99  ? 19.581  6.721  19.505 1.00 32.04 ? 79  GLN   A HA   1 
ATOM   996  H  HB2  . GLN   A 1 99  ? 20.774  8.626  18.979 1.00 42.27 ? 79  GLN   A HB2  1 
ATOM   997  H  HB3  . GLN   A 1 99  ? 19.899  9.484  19.985 1.00 42.27 ? 79  GLN   A HB3  1 
ATOM   998  H  HG2  . GLN   A 1 99  ? 20.927  8.627  21.770 1.00 51.83 ? 79  GLN   A HG2  1 
ATOM   999  H  HG3  . GLN   A 1 99  ? 21.528  7.417  20.934 1.00 51.83 ? 79  GLN   A HG3  1 
ATOM   1000 H  HE21 . GLN   A 1 99  ? 23.685  7.576  20.763 1.00 71.79 ? 79  GLN   A HE21 1 
ATOM   1001 H  HE22 . GLN   A 1 99  ? 24.471  8.825  20.558 1.00 71.79 ? 79  GLN   A HE22 1 
ATOM   1002 N  N    . CYS   A 1 100 ? 17.666  8.394  21.460 1.00 20.24 ? 80  CYS   A N    1 
ATOM   1003 C  CA   . CYS   A 1 100 ? 17.068  8.412  22.788 1.00 19.62 ? 80  CYS   A CA   1 
ATOM   1004 C  C    . CYS   A 1 100 ? 15.829  7.535  22.888 1.00 17.94 ? 80  CYS   A C    1 
ATOM   1005 O  O    . CYS   A 1 100 ? 15.492  7.074  23.986 1.00 18.99 ? 80  CYS   A O    1 
ATOM   1006 C  CB   . CYS   A 1 100 ? 16.704  9.844  23.175 1.00 33.83 ? 80  CYS   A CB   1 
ATOM   1007 S  SG   . CYS   A 1 100 ? 18.110  10.933 23.362 1.00 51.09 ? 80  CYS   A SG   1 
ATOM   1008 H  H    . CYS   A 1 100 ? 17.438  9.055  20.960 1.00 24.30 ? 80  CYS   A H    1 
ATOM   1009 H  HA   . CYS   A 1 100 ? 17.718  8.085  23.430 1.00 23.56 ? 80  CYS   A HA   1 
ATOM   1010 H  HB2  . CYS   A 1 100 ? 16.132  10.217 22.486 1.00 40.62 ? 80  CYS   A HB2  1 
ATOM   1011 H  HB3  . CYS   A 1 100 ? 16.230  9.827  24.021 1.00 40.62 ? 80  CYS   A HB3  1 
ATOM   1012 H  HG   . CYS   A 1 100 ? 17.720  12.027 23.665 1.00 61.32 ? 80  CYS   A HG   1 
ATOM   1013 N  N    . PHE   A 1 101 ? 15.133  7.310  21.776 1.00 18.24 ? 81  PHE   A N    1 
ATOM   1014 C  CA   . PHE   A 1 101 ? 13.931  6.478  21.740 1.00 18.97 ? 81  PHE   A CA   1 
ATOM   1015 C  C    . PHE   A 1 101 ? 14.083  5.476  20.601 1.00 16.16 ? 81  PHE   A C    1 
ATOM   1016 O  O    . PHE   A 1 101 ? 13.391  5.566  19.577 1.00 16.63 ? 81  PHE   A O    1 
ATOM   1017 C  CB   . PHE   A 1 101 ? 12.666  7.312  21.539 1.00 17.69 ? 81  PHE   A CB   1 
ATOM   1018 C  CG   . PHE   A 1 101 ? 12.417  8.347  22.594 1.00 19.09 ? 81  PHE   A CG   1 
ATOM   1019 C  CD1  . PHE   A 1 101 ? 12.007  7.979  23.865 1.00 17.16 ? 81  PHE   A CD1  1 
ATOM   1020 C  CD2  . PHE   A 1 101 ? 12.539  9.694  22.300 1.00 19.35 ? 81  PHE   A CD2  1 
ATOM   1021 C  CE1  . PHE   A 1 101 ? 11.747  8.937  24.824 1.00 17.81 ? 81  PHE   A CE1  1 
ATOM   1022 C  CE2  . PHE   A 1 101 ? 12.284  10.655 23.257 1.00 19.93 ? 81  PHE   A CE2  1 
ATOM   1023 C  CZ   . PHE   A 1 101 ? 11.879  10.275 24.521 1.00 18.87 ? 81  PHE   A CZ   1 
ATOM   1024 H  H    . PHE   A 1 101 ? 15.343  7.637  21.009 1.00 21.90 ? 81  PHE   A H    1 
ATOM   1025 H  HA   . PHE   A 1 101 ? 13.845  5.990  22.573 1.00 22.79 ? 81  PHE   A HA   1 
ATOM   1026 H  HB2  . PHE   A 1 101 ? 12.728  7.770  20.686 1.00 21.25 ? 81  PHE   A HB2  1 
ATOM   1027 H  HB3  . PHE   A 1 101 ? 11.903  6.715  21.535 1.00 21.25 ? 81  PHE   A HB3  1 
ATOM   1028 H  HD1  . PHE   A 1 101 ? 11.908  7.078  24.075 1.00 20.61 ? 81  PHE   A HD1  1 
ATOM   1029 H  HD2  . PHE   A 1 101 ? 12.804  9.955  21.448 1.00 23.23 ? 81  PHE   A HD2  1 
ATOM   1030 H  HE1  . PHE   A 1 101 ? 11.480  8.679  25.677 1.00 21.39 ? 81  PHE   A HE1  1 
ATOM   1031 H  HE2  . PHE   A 1 101 ? 12.377  11.557 23.049 1.00 23.93 ? 81  PHE   A HE2  1 
ATOM   1032 H  HZ   . PHE   A 1 101 ? 11.713  10.919 25.171 1.00 22.66 ? 81  PHE   A HZ   1 
ATOM   1033 N  N    . PRO   A 1 102 ? 14.981  4.499  20.751 1.00 16.76 ? 82  PRO   A N    1 
ATOM   1034 C  CA   . PRO   A 1 102 ? 15.443  3.737  19.577 1.00 20.17 ? 82  PRO   A CA   1 
ATOM   1035 C  C    . PRO   A 1 102 ? 14.411  2.800  18.976 1.00 21.01 ? 82  PRO   A C    1 
ATOM   1036 O  O    . PRO   A 1 102 ? 14.561  2.433  17.804 1.00 25.35 ? 82  PRO   A O    1 
ATOM   1037 C  CB   . PRO   A 1 102 ? 16.648  2.953  20.119 1.00 22.76 ? 82  PRO   A CB   1 
ATOM   1038 C  CG   . PRO   A 1 102 ? 16.383  2.841  21.592 1.00 20.82 ? 82  PRO   A CG   1 
ATOM   1039 C  CD   . PRO   A 1 102 ? 15.730  4.145  21.973 1.00 17.97 ? 82  PRO   A CD   1 
ATOM   1040 H  HA   . PRO   A 1 102 ? 15.748  4.346  18.888 1.00 24.22 ? 82  PRO   A HA   1 
ATOM   1041 H  HB2  . PRO   A 1 102 ? 16.683  2.076  19.706 1.00 27.33 ? 82  PRO   A HB2  1 
ATOM   1042 H  HB3  . PRO   A 1 102 ? 17.465  3.448  19.951 1.00 27.33 ? 82  PRO   A HB3  1 
ATOM   1043 H  HG2  . PRO   A 1 102 ? 15.786  2.096  21.761 1.00 25.00 ? 82  PRO   A HG2  1 
ATOM   1044 H  HG3  . PRO   A 1 102 ? 17.221  2.725  22.067 1.00 25.00 ? 82  PRO   A HG3  1 
ATOM   1045 H  HD2  . PRO   A 1 102 ? 15.123  4.017  22.719 1.00 21.58 ? 82  PRO   A HD2  1 
ATOM   1046 H  HD3  . PRO   A 1 102 ? 16.401  4.818  22.168 1.00 21.58 ? 82  PRO   A HD3  1 
ATOM   1047 N  N    . ASP   A 1 103 ? 13.387  2.388  19.725 1.00 17.66 ? 83  ASP   A N    1 
ATOM   1048 C  CA   . ASP   A 1 103 ? 12.400  1.443  19.213 1.00 18.19 ? 83  ASP   A CA   1 
ATOM   1049 C  C    . ASP   A 1 103 ? 10.979  1.947  19.432 1.00 17.97 ? 83  ASP   A C    1 
ATOM   1050 O  O    . ASP   A 1 103 ? 10.038  1.154  19.502 1.00 20.00 ? 83  ASP   A O    1 
ATOM   1051 C  CB   . ASP   A 1 103 ? 12.580  0.061  19.845 1.00 21.07 ? 83  ASP   A CB   1 
ATOM   1052 C  CG   . ASP   A 1 103 ? 12.390  0.064  21.364 1.00 28.71 ? 83  ASP   A CG   1 
ATOM   1053 O  OD1  . ASP   A 1 103 ? 12.121  1.133  21.954 1.00 22.28 ? 83  ASP   A OD1  1 
ATOM   1054 O  OD2  . ASP   A 1 103 ? 12.513  -1.022 21.971 1.00 24.82 ? 83  ASP   A OD2  1 
ATOM   1055 H  H    . ASP   A 1 103 ? 13.243  2.642  20.534 1.00 21.20 ? 83  ASP   A H    1 
ATOM   1056 H  HA   . ASP   A 1 103 ? 12.527  1.344  18.257 1.00 21.85 ? 83  ASP   A HA   1 
ATOM   1057 H  HB2  . ASP   A 1 103 ? 11.928  -0.547 19.464 1.00 25.31 ? 83  ASP   A HB2  1 
ATOM   1058 H  HB3  . ASP   A 1 103 ? 13.477  -0.256 19.657 1.00 25.31 ? 83  ASP   A HB3  1 
ATOM   1059 N  N    . TRP   A 1 104 ? 10.812  3.264  19.498 1.00 17.17 ? 84  TRP   A N    1 
ATOM   1060 C  CA   . TRP   A 1 104 ? 9.532   3.863  19.844 1.00 13.77 ? 84  TRP   A CA   1 
ATOM   1061 C  C    . TRP   A 1 104 ? 8.427   3.453  18.880 1.00 15.48 ? 84  TRP   A C    1 
ATOM   1062 O  O    . TRP   A 1 104 ? 8.608   3.466  17.660 1.00 17.88 ? 84  TRP   A O    1 
ATOM   1063 C  CB   . TRP   A 1 104 ? 9.667   5.386  19.823 1.00 13.37 ? 84  TRP   A CB   1 
ATOM   1064 C  CG   . TRP   A 1 104 ? 8.495   6.072  20.394 1.00 15.17 ? 84  TRP   A CG   1 
ATOM   1065 C  CD1  . TRP   A 1 104 ? 7.483   6.684  19.715 1.00 17.38 ? 84  TRP   A CD1  1 
ATOM   1066 C  CD2  . TRP   A 1 104 ? 8.192   6.208  21.783 1.00 11.61 ? 84  TRP   A CD2  1 
ATOM   1067 N  NE1  . TRP   A 1 104 ? 6.568   7.199  20.601 1.00 15.17 ? 84  TRP   A NE1  1 
ATOM   1068 C  CE2  . TRP   A 1 104 ? 6.985   6.921  21.878 1.00 13.21 ? 84  TRP   A CE2  1 
ATOM   1069 C  CE3  . TRP   A 1 104 ? 8.834   5.805  22.956 1.00 11.55 ? 84  TRP   A CE3  1 
ATOM   1070 C  CZ2  . TRP   A 1 104 ? 6.401   7.236  23.105 1.00 13.73 ? 84  TRP   A CZ2  1 
ATOM   1071 C  CZ3  . TRP   A 1 104 ? 8.257   6.107  24.168 1.00 14.70 ? 84  TRP   A CZ3  1 
ATOM   1072 C  CH2  . TRP   A 1 104 ? 7.050   6.816  24.237 1.00 15.07 ? 84  TRP   A CH2  1 
ATOM   1073 H  H    . TRP   A 1 104 ? 11.434  3.838  19.344 1.00 20.62 ? 84  TRP   A H    1 
ATOM   1074 H  HA   . TRP   A 1 104 ? 9.277   3.589  20.739 1.00 16.54 ? 84  TRP   A HA   1 
ATOM   1075 H  HB2  . TRP   A 1 104 ? 10.445  5.639  20.341 1.00 16.06 ? 84  TRP   A HB2  1 
ATOM   1076 H  HB3  . TRP   A 1 104 ? 9.769   5.681  18.905 1.00 16.06 ? 84  TRP   A HB3  1 
ATOM   1077 H  HD1  . TRP   A 1 104 ? 7.421   6.743  18.789 1.00 20.87 ? 84  TRP   A HD1  1 
ATOM   1078 H  HE1  . TRP   A 1 104 ? 5.853   7.627  20.390 1.00 18.22 ? 84  TRP   A HE1  1 
ATOM   1079 H  HE3  . TRP   A 1 104 ? 9.633   5.331  22.918 1.00 13.87 ? 84  TRP   A HE3  1 
ATOM   1080 H  HZ2  . TRP   A 1 104 ? 5.600   7.705  23.153 1.00 16.50 ? 84  TRP   A HZ2  1 
ATOM   1081 H  HZ3  . TRP   A 1 104 ? 8.677   5.841  24.954 1.00 17.66 ? 84  TRP   A HZ3  1 
ATOM   1082 H  HH2  . TRP   A 1 104 ? 6.685   7.013  25.070 1.00 18.11 ? 84  TRP   A HH2  1 
ATOM   1083 N  N    . VAL   A 1 105 ? 7.259   3.128  19.428 1.00 14.62 ? 85  VAL   A N    1 
ATOM   1084 C  CA   . VAL   A 1 105 ? 6.072   2.896  18.619 1.00 14.62 ? 85  VAL   A CA   1 
ATOM   1085 C  C    . VAL   A 1 105 ? 4.893   3.630  19.240 1.00 14.63 ? 85  VAL   A C    1 
ATOM   1086 O  O    . VAL   A 1 105 ? 4.783   3.730  20.468 1.00 13.93 ? 85  VAL   A O    1 
ATOM   1087 C  CB   . VAL   A 1 105 ? 5.743   1.394  18.463 1.00 16.79 ? 85  VAL   A CB   1 
ATOM   1088 C  CG1  . VAL   A 1 105 ? 6.844   0.687  17.691 1.00 21.06 ? 85  VAL   A CG1  1 
ATOM   1089 C  CG2  . VAL   A 1 105 ? 5.531   0.759  19.814 1.00 16.84 ? 85  VAL   A CG2  1 
ATOM   1090 H  H    . VAL   A 1 105 ? 7.130   3.036  20.273 1.00 17.56 ? 85  VAL   A H    1 
ATOM   1091 H  HA   . VAL   A 1 105 ? 6.216   3.262  17.733 1.00 17.56 ? 85  VAL   A HA   1 
ATOM   1092 H  HB   . VAL   A 1 105 ? 4.920   1.303  17.958 1.00 20.16 ? 85  VAL   A HB   1 
ATOM   1093 H  HG11 . VAL   A 1 105 ? 6.586   -0.237 17.548 1.00 25.29 ? 85  VAL   A HG11 1 
ATOM   1094 H  HG12 . VAL   A 1 105 ? 6.967   1.133  16.839 1.00 25.29 ? 85  VAL   A HG12 1 
ATOM   1095 H  HG13 . VAL   A 1 105 ? 7.665   0.726  18.206 1.00 25.29 ? 85  VAL   A HG13 1 
ATOM   1096 H  HG21 . VAL   A 1 105 ? 5.426   -0.198 19.697 1.00 20.23 ? 85  VAL   A HG21 1 
ATOM   1097 H  HG22 . VAL   A 1 105 ? 6.302   0.940  20.374 1.00 20.23 ? 85  VAL   A HG22 1 
ATOM   1098 H  HG23 . VAL   A 1 105 ? 4.732   1.131  20.220 1.00 20.23 ? 85  VAL   A HG23 1 
ATOM   1099 N  N    . TRP   A 1 106 ? 4.023   4.154  18.379 1.00 13.84 ? 86  TRP   A N    1 
ATOM   1100 C  CA   . TRP   A 1 106 ? 2.707   4.620  18.772 1.00 14.00 ? 86  TRP   A CA   1 
ATOM   1101 C  C    . TRP   A 1 106 ? 1.708   3.479  18.609 1.00 15.56 ? 86  TRP   A C    1 
ATOM   1102 O  O    . TRP   A 1 106 ? 1.732   2.757  17.608 1.00 17.39 ? 86  TRP   A O    1 
ATOM   1103 C  CB   . TRP   A 1 106 ? 2.272   5.796  17.912 1.00 15.09 ? 86  TRP   A CB   1 
ATOM   1104 C  CG   . TRP   A 1 106 ? 3.236   6.940  17.849 1.00 15.16 ? 86  TRP   A CG   1 
ATOM   1105 C  CD1  . TRP   A 1 106 ? 3.997   7.309  16.777 1.00 16.67 ? 86  TRP   A CD1  1 
ATOM   1106 C  CD2  . TRP   A 1 106 ? 3.528   7.879  18.888 1.00 13.61 ? 86  TRP   A CD2  1 
ATOM   1107 N  NE1  . TRP   A 1 106 ? 4.737   8.423  17.080 1.00 14.70 ? 86  TRP   A NE1  1 
ATOM   1108 C  CE2  . TRP   A 1 106 ? 4.477   8.787  18.375 1.00 14.89 ? 86  TRP   A CE2  1 
ATOM   1109 C  CE3  . TRP   A 1 106 ? 3.083   8.040  20.206 1.00 14.79 ? 86  TRP   A CE3  1 
ATOM   1110 C  CZ2  . TRP   A 1 106 ? 4.985   9.840  19.130 1.00 14.91 ? 86  TRP   A CZ2  1 
ATOM   1111 C  CZ3  . TRP   A 1 106 ? 3.594   9.085  20.952 1.00 16.49 ? 86  TRP   A CZ3  1 
ATOM   1112 C  CH2  . TRP   A 1 106 ? 4.536   9.968  20.415 1.00 12.93 ? 86  TRP   A CH2  1 
ATOM   1113 H  H    . TRP   A 1 106 ? 4.182   4.250  17.539 1.00 16.63 ? 86  TRP   A H    1 
ATOM   1114 H  HA   . TRP   A 1 106 ? 2.718   4.898  19.701 1.00 16.82 ? 86  TRP   A HA   1 
ATOM   1115 H  HB2  . TRP   A 1 106 ? 2.137   5.479  17.005 1.00 18.12 ? 86  TRP   A HB2  1 
ATOM   1116 H  HB3  . TRP   A 1 106 ? 1.435   6.140  18.263 1.00 18.12 ? 86  TRP   A HB3  1 
ATOM   1117 H  HD1  . TRP   A 1 106 ? 3.999   6.878  15.953 1.00 20.02 ? 86  TRP   A HD1  1 
ATOM   1118 H  HE1  . TRP   A 1 106 ? 5.289   8.816  16.551 1.00 17.66 ? 86  TRP   A HE1  1 
ATOM   1119 H  HE3  . TRP   A 1 106 ? 2.458   7.456  20.571 1.00 17.77 ? 86  TRP   A HE3  1 
ATOM   1120 H  HZ2  . TRP   A 1 106 ? 5.613   10.428 18.777 1.00 17.91 ? 86  TRP   A HZ2  1 
ATOM   1121 H  HZ3  . TRP   A 1 106 ? 3.308   9.202  21.829 1.00 19.80 ? 86  TRP   A HZ3  1 
ATOM   1122 H  HH2  . TRP   A 1 106 ? 4.860   10.662 20.942 1.00 15.53 ? 86  TRP   A HH2  1 
ATOM   1123 N  N    . THR   A 1 107 ? 0.820   3.329  19.590 1.00 15.33 ? 87  THR   A N    1 
ATOM   1124 C  CA   . THR   A 1 107 ? -0.146  2.243  19.623 1.00 14.31 ? 87  THR   A CA   1 
ATOM   1125 C  C    . THR   A 1 107 ? -1.527  2.783  19.987 1.00 17.99 ? 87  THR   A C    1 
ATOM   1126 O  O    . THR   A 1 107 ? -1.679  3.935  20.399 1.00 15.35 ? 87  THR   A O    1 
ATOM   1127 C  CB   . THR   A 1 107 ? 0.265   1.163  20.635 1.00 14.66 ? 87  THR   A CB   1 
ATOM   1128 O  OG1  . THR   A 1 107 ? 0.138   1.694  21.962 1.00 17.72 ? 87  THR   A OG1  1 
ATOM   1129 C  CG2  . THR   A 1 107 ? 1.703   0.731  20.416 1.00 22.04 ? 87  THR   A CG2  1 
ATOM   1130 H  H    . THR   A 1 107 ? 0.759   3.860  20.264 1.00 18.42 ? 87  THR   A H    1 
ATOM   1131 H  HA   . THR   A 1 107 ? -0.202  1.833  18.746 1.00 17.19 ? 87  THR   A HA   1 
ATOM   1132 H  HB   . THR   A 1 107 ? -0.310  0.388  20.537 1.00 17.61 ? 87  THR   A HB   1 
ATOM   1133 H  HG1  . THR   A 1 107 ? -0.673  1.783  22.162 1.00 21.29 ? 87  THR   A HG1  1 
ATOM   1134 H  HG21 . THR   A 1 107 ? 1.914   -0.020 20.993 1.00 26.47 ? 87  THR   A HG21 1 
ATOM   1135 H  HG22 . THR   A 1 107 ? 1.831   0.465  19.492 1.00 26.47 ? 87  THR   A HG22 1 
ATOM   1136 H  HG23 . THR   A 1 107 ? 2.305   1.464  20.619 1.00 26.47 ? 87  THR   A HG23 1 
ATOM   1137 N  N    . ASP   A 1 108 ? -2.547  1.937  19.825 1.00 15.43 ? 88  ASP   A N    1 
ATOM   1138 C  CA   . ASP   A 1 108 ? -3.916  2.314  20.184 1.00 15.55 ? 88  ASP   A CA   1 
ATOM   1139 C  C    . ASP   A 1 108 ? -4.301  3.641  19.536 1.00 15.35 ? 88  ASP   A C    1 
ATOM   1140 O  O    . ASP   A 1 108 ? -4.905  4.517  20.160 1.00 17.13 ? 88  ASP   A O    1 
ATOM   1141 C  CB   . ASP   A 1 108 ? -4.053  2.381  21.701 1.00 17.07 ? 88  ASP   A CB   1 
ATOM   1142 C  CG   . ASP   A 1 108 ? -3.619  1.097  22.369 0.42 23.83 ? 88  ASP   A CG   1 
ATOM   1143 O  OD1  . ASP   A 1 108 ? -4.445  0.165  22.438 0.64 27.37 ? 88  ASP   A OD1  1 
ATOM   1144 O  OD2  . ASP   A 1 108 ? -2.438  1.007  22.772 0.82 20.28 ? 88  ASP   A OD2  1 
ATOM   1145 H  H    . ASP   A 1 108 ? -2.473  1.141  19.510 1.00 18.53 ? 88  ASP   A H    1 
ATOM   1146 H  HA   . ASP   A 1 108 ? -4.526  1.634  19.858 1.00 18.67 ? 88  ASP   A HA   1 
ATOM   1147 H  HB2  . ASP   A 1 108 ? -3.497  3.100  22.039 1.00 20.51 ? 88  ASP   A HB2  1 
ATOM   1148 H  HB3  . ASP   A 1 108 ? -4.982  2.541  21.930 1.00 20.51 ? 88  ASP   A HB3  1 
ATOM   1149 N  N    . ILE   A 1 109 ? -3.956  3.778  18.260 1.00 17.27 ? 89  ILE   A N    1 
ATOM   1150 C  CA   . ILE   A 1 109 ? -4.091  5.047  17.556 1.00 16.88 ? 89  ILE   A CA   1 
ATOM   1151 C  C    . ILE   A 1 109 ? -5.546  5.279  17.178 1.00 18.96 ? 89  ILE   A C    1 
ATOM   1152 O  O    . ILE   A 1 109 ? -6.159  4.458  16.486 1.00 18.49 ? 89  ILE   A O    1 
ATOM   1153 C  CB   . ILE   A 1 109 ? -3.211  5.057  16.295 1.00 17.07 ? 89  ILE   A CB   1 
ATOM   1154 C  CG1  . ILE   A 1 109 ? -1.736  4.963  16.652 1.00 18.35 ? 89  ILE   A CG1  1 
ATOM   1155 C  CG2  . ILE   A 1 109 ? -3.500  6.294  15.456 1.00 17.83 ? 89  ILE   A CG2  1 
ATOM   1156 C  CD1  . ILE   A 1 109 ? -0.874  4.533  15.494 1.00 18.30 ? 89  ILE   A CD1  1 
ATOM   1157 H  H    . ILE   A 1 109 ? -3.638  3.143  17.775 1.00 20.74 ? 89  ILE   A H    1 
ATOM   1158 H  HA   . ILE   A 1 109 ? -3.805  5.770  18.136 1.00 20.28 ? 89  ILE   A HA   1 
ATOM   1159 H  HB   . ILE   A 1 109 ? -3.440  4.277  15.765 1.00 20.51 ? 89  ILE   A HB   1 
ATOM   1160 H  HG12 . ILE   A 1 109 ? -1.428  5.834  16.946 1.00 22.04 ? 89  ILE   A HG12 1 
ATOM   1161 H  HG13 . ILE   A 1 109 ? -1.622  4.315  17.364 1.00 22.04 ? 89  ILE   A HG13 1 
ATOM   1162 H  HG21 . ILE   A 1 109 ? -2.760  6.446  14.849 1.00 21.42 ? 89  ILE   A HG21 1 
ATOM   1163 H  HG22 . ILE   A 1 109 ? -4.315  6.152  14.950 1.00 21.42 ? 89  ILE   A HG22 1 
ATOM   1164 H  HG23 . ILE   A 1 109 ? -3.603  7.057  16.046 1.00 21.42 ? 89  ILE   A HG23 1 
ATOM   1165 H  HD11 . ILE   A 1 109 ? 0.036   4.413  15.807 1.00 21.97 ? 89  ILE   A HD11 1 
ATOM   1166 H  HD12 . ILE   A 1 109 ? -1.215  3.696  15.141 1.00 21.97 ? 89  ILE   A HD12 1 
ATOM   1167 H  HD13 . ILE   A 1 109 ? -0.900  5.217  14.807 1.00 21.97 ? 89  ILE   A HD13 1 
ATOM   1168 N  N    . GLN   A 1 110 ? -6.086  6.425  17.587 1.00 13.99 ? 90  GLN   A N    1 
ATOM   1169 C  CA   . GLN   A 1 110 ? -7.422  6.853  17.190 1.00 15.76 ? 90  GLN   A CA   1 
ATOM   1170 C  C    . GLN   A 1 110 ? -7.295  8.241  16.585 1.00 14.76 ? 90  GLN   A C    1 
ATOM   1171 O  O    . GLN   A 1 110 ? -6.884  9.182  17.274 1.00 14.30 ? 90  GLN   A O    1 
ATOM   1172 C  CB   . GLN   A 1 110 ? -8.387  6.895  18.376 1.00 16.88 ? 90  GLN   A CB   1 
ATOM   1173 C  CG   . GLN   A 1 110 ? -8.386  5.680  19.261 1.00 27.58 ? 90  GLN   A CG   1 
ATOM   1174 C  CD   . GLN   A 1 110 ? -9.373  5.825  20.405 1.00 43.32 ? 90  GLN   A CD   1 
ATOM   1175 O  OE1  . GLN   A 1 110 ? -9.034  6.332  21.479 1.00 33.49 ? 90  GLN   A OE1  1 
ATOM   1176 N  NE2  . GLN   A 1 110 ? -10.610 5.405  20.170 1.00 28.40 ? 90  GLN   A NE2  1 
ATOM   1177 H  H    . GLN   A 1 110 ? -5.688  6.983  18.106 1.00 16.80 ? 90  GLN   A H    1 
ATOM   1178 H  HA   . GLN   A 1 110 ? -7.778  6.251  16.518 1.00 18.93 ? 90  GLN   A HA   1 
ATOM   1179 H  HB2  . GLN   A 1 110 ? -8.158  7.658  18.930 1.00 20.27 ? 90  GLN   A HB2  1 
ATOM   1180 H  HB3  . GLN   A 1 110 ? -9.288  7.004  18.034 1.00 20.27 ? 90  GLN   A HB3  1 
ATOM   1181 H  HG2  . GLN   A 1 110 ? -8.638  4.903  18.738 1.00 33.12 ? 90  GLN   A HG2  1 
ATOM   1182 H  HG3  . GLN   A 1 110 ? -7.501  5.558  19.638 1.00 33.12 ? 90  GLN   A HG3  1 
ATOM   1183 H  HE21 . GLN   A 1 110 ? -10.810 5.061  19.407 1.00 34.10 ? 90  GLN   A HE21 1 
ATOM   1184 H  HE22 . GLN   A 1 110 ? -11.209 5.466  20.784 1.00 34.10 ? 90  GLN   A HE22 1 
ATOM   1185 N  N    . ILE   A 1 111 ? -7.633  8.372  15.307 1.00 14.01 ? 91  ILE   A N    1 
ATOM   1186 C  CA   . ILE   A 1 111 ? -7.517  9.641  14.598 1.00 15.13 ? 91  ILE   A CA   1 
ATOM   1187 C  C    . ILE   A 1 111 ? -8.869  10.336 14.604 1.00 19.77 ? 91  ILE   A C    1 
ATOM   1188 O  O    . ILE   A 1 111 ? -9.891  9.727  14.261 1.00 18.90 ? 91  ILE   A O    1 
ATOM   1189 C  CB   . ILE   A 1 111 ? -7.020  9.431  13.158 1.00 16.84 ? 91  ILE   A CB   1 
ATOM   1190 C  CG1  . ILE   A 1 111 ? -5.616  8.823  13.188 1.00 17.04 ? 91  ILE   A CG1  1 
ATOM   1191 C  CG2  . ILE   A 1 111 ? -7.035  10.748 12.401 1.00 17.76 ? 91  ILE   A CG2  1 
ATOM   1192 C  CD1  . ILE   A 1 111 ? -5.085  8.384  11.837 1.00 23.10 ? 91  ILE   A CD1  1 
ATOM   1193 H  H    . ILE   A 1 111 ? -7.937  7.731  14.821 1.00 16.83 ? 91  ILE   A H    1 
ATOM   1194 H  HA   . ILE   A 1 111 ? -6.880  10.210 15.058 1.00 18.17 ? 91  ILE   A HA   1 
ATOM   1195 H  HB   . ILE   A 1 111 ? -7.617  8.810  12.712 1.00 20.23 ? 91  ILE   A HB   1 
ATOM   1196 H  HG12 . ILE   A 1 111 ? -5.001  9.483  13.544 1.00 20.46 ? 91  ILE   A HG12 1 
ATOM   1197 H  HG13 . ILE   A 1 111 ? -5.626  8.043  13.764 1.00 20.46 ? 91  ILE   A HG13 1 
ATOM   1198 H  HG21 . ILE   A 1 111 ? -6.530  10.649 11.579 1.00 21.33 ? 91  ILE   A HG21 1 
ATOM   1199 H  HG22 . ILE   A 1 111 ? -7.952  10.986 12.193 1.00 21.33 ? 91  ILE   A HG22 1 
ATOM   1200 H  HG23 . ILE   A 1 111 ? -6.631  11.434 12.955 1.00 21.33 ? 91  ILE   A HG23 1 
ATOM   1201 H  HD11 . ILE   A 1 111 ? -4.284  7.854  11.971 1.00 27.73 ? 91  ILE   A HD11 1 
ATOM   1202 H  HD12 . ILE   A 1 111 ? -5.762  7.853  11.390 1.00 27.73 ? 91  ILE   A HD12 1 
ATOM   1203 H  HD13 . ILE   A 1 111 ? -4.877  9.169  11.307 1.00 27.73 ? 91  ILE   A HD13 1 
ATOM   1204 N  N    . PHE   A 1 112 ? -8.877  11.612 14.978 1.00 12.86 ? 92  PHE   A N    1 
ATOM   1205 C  CA   . PHE   A 1 112 ? -10.087 12.421 14.952 1.00 14.21 ? 92  PHE   A CA   1 
ATOM   1206 C  C    . PHE   A 1 112 ? -9.975  13.511 13.895 1.00 15.64 ? 92  PHE   A C    1 
ATOM   1207 O  O    . PHE   A 1 112 ? -9.134  14.410 14.004 1.00 15.78 ? 92  PHE   A O    1 
ATOM   1208 C  CB   . PHE   A 1 112 ? -10.339 13.024 16.330 1.00 13.73 ? 92  PHE   A CB   1 
ATOM   1209 C  CG   . PHE   A 1 112 ? -10.521 12.002 17.409 1.00 12.51 ? 92  PHE   A CG   1 
ATOM   1210 C  CD1  . PHE   A 1 112 ? -11.764 11.436 17.625 1.00 14.39 ? 92  PHE   A CD1  1 
ATOM   1211 C  CD2  . PHE   A 1 112 ? -9.459  11.596 18.194 1.00 14.16 ? 92  PHE   A CD2  1 
ATOM   1212 C  CE1  . PHE   A 1 112 ? -11.948 10.489 18.610 1.00 16.16 ? 92  PHE   A CE1  1 
ATOM   1213 C  CE2  . PHE   A 1 112 ? -9.637  10.645 19.185 1.00 18.13 ? 92  PHE   A CE2  1 
ATOM   1214 C  CZ   . PHE   A 1 112 ? -10.886 10.093 19.392 1.00 16.74 ? 92  PHE   A CZ   1 
ATOM   1215 H  H    . PHE   A 1 112 ? -8.182  12.037 15.255 1.00 15.45 ? 92  PHE   A H    1 
ATOM   1216 H  HA   . PHE   A 1 112 ? -10.845 11.860 14.726 1.00 17.07 ? 92  PHE   A HA   1 
ATOM   1217 H  HB2  . PHE   A 1 112 ? -9.581  13.580 16.572 1.00 16.50 ? 92  PHE   A HB2  1 
ATOM   1218 H  HB3  . PHE   A 1 112 ? -11.144 13.563 16.293 1.00 16.50 ? 92  PHE   A HB3  1 
ATOM   1219 H  HD1  . PHE   A 1 112 ? -12.486 11.700 17.101 1.00 17.29 ? 92  PHE   A HD1  1 
ATOM   1220 H  HD2  . PHE   A 1 112 ? -8.617  11.967 18.057 1.00 17.01 ? 92  PHE   A HD2  1 
ATOM   1221 H  HE1  . PHE   A 1 112 ? -12.790 10.119 18.747 1.00 19.41 ? 92  PHE   A HE1  1 
ATOM   1222 H  HE2  . PHE   A 1 112 ? -8.917  10.380 19.711 1.00 21.77 ? 92  PHE   A HE2  1 
ATOM   1223 H  HZ   . PHE   A 1 112 ? -11.009 9.454  20.057 1.00 20.10 ? 92  PHE   A HZ   1 
ATOM   1224 N  N    . GLU   A 1 113 ? -10.816 13.417 12.869 1.00 13.91 ? 93  GLU   A N    1 
ATOM   1225 C  CA   . GLU   A 1 113 ? -11.064 14.554 11.999 1.00 15.00 ? 93  GLU   A CA   1 
ATOM   1226 C  C    . GLU   A 1 113 ? -11.832 15.610 12.782 1.00 18.07 ? 93  GLU   A C    1 
ATOM   1227 O  O    . GLU   A 1 113 ? -12.450 15.316 13.806 1.00 18.44 ? 93  GLU   A O    1 
ATOM   1228 C  CB   . GLU   A 1 113 ? -11.870 14.130 10.772 1.00 18.98 ? 93  GLU   A CB   1 
ATOM   1229 C  CG   . GLU   A 1 113 ? -11.289 12.939 10.030 1.00 27.41 ? 93  GLU   A CG   1 
ATOM   1230 C  CD   . GLU   A 1 113 ? -12.264 12.307 9.038  1.00 32.32 ? 93  GLU   A CD   1 
ATOM   1231 O  OE1  . GLU   A 1 113 ? -13.410 12.794 8.901  1.00 31.60 ? 93  GLU   A OE1  1 
ATOM   1232 O  OE2  . GLU   A 1 113 ? -11.873 11.308 8.401  1.00 49.28 ? 93  GLU   A OE2  1 
ATOM   1233 H  H    . GLU   A 1 113 ? -11.255 12.708 12.662 1.00 16.71 ? 93  GLU   A H    1 
ATOM   1234 H  HA   . GLU   A 1 113 ? -10.221 14.933 11.705 1.00 18.01 ? 93  GLU   A HA   1 
ATOM   1235 H  HB2  . GLU   A 1 113 ? -12.767 13.894 11.055 1.00 22.79 ? 93  GLU   A HB2  1 
ATOM   1236 H  HB3  . GLU   A 1 113 ? -11.907 14.876 10.154 1.00 22.79 ? 93  GLU   A HB3  1 
ATOM   1237 H  HG2  . GLU   A 1 113 ? -10.514 13.232 9.529  1.00 32.91 ? 93  GLU   A HG2  1 
ATOM   1238 H  HG3  . GLU   A 1 113 ? -11.031 12.254 10.666 1.00 32.91 ? 93  GLU   A HG3  1 
ATOM   1239 N  N    . THR   A 1 114 ? -11.799 16.850 12.301 1.00 16.69 ? 94  THR   A N    1 
ATOM   1240 C  CA   . THR   A 1 114 ? -12.600 17.898 12.918 1.00 14.09 ? 94  THR   A CA   1 
ATOM   1241 C  C    . THR   A 1 114 ? -13.345 18.678 11.837 1.00 15.97 ? 94  THR   A C    1 
ATOM   1242 O  O    . THR   A 1 114 ? -13.217 18.410 10.639 1.00 18.07 ? 94  THR   A O    1 
ATOM   1243 C  CB   . THR   A 1 114 ? -11.758 18.869 13.760 1.00 15.18 ? 94  THR   A CB   1 
ATOM   1244 O  OG1  . THR   A 1 114 ? -11.022 19.761 12.909 1.00 15.93 ? 94  THR   A OG1  1 
ATOM   1245 C  CG2  . THR   A 1 114 ? -10.775 18.119 14.642 1.00 13.78 ? 94  THR   A CG2  1 
ATOM   1246 H  H    . THR   A 1 114 ? -11.328 17.106 11.629 1.00 20.04 ? 94  THR   A H    1 
ATOM   1247 H  HA   . THR   A 1 114 ? -13.262 17.492 13.493 1.00 16.93 ? 94  THR   A HA   1 
ATOM   1248 H  HB   . THR   A 1 114 ? -12.345 19.387 14.333 1.00 18.24 ? 94  THR   A HB   1 
ATOM   1249 H  HG1  . THR   A 1 114 ? -10.509 19.323 12.409 1.00 19.13 ? 94  THR   A HG1  1 
ATOM   1250 H  HG21 . THR   A 1 114 ? -10.323 18.739 15.236 1.00 16.55 ? 94  THR   A HG21 1 
ATOM   1251 H  HG22 . THR   A 1 114 ? -11.245 17.459 15.175 1.00 16.55 ? 94  THR   A HG22 1 
ATOM   1252 H  HG23 . THR   A 1 114 ? -10.113 17.668 14.095 1.00 16.55 ? 94  THR   A HG23 1 
ATOM   1253 N  N    . GLN   A 1 115 ? -14.121 19.670 12.280 1.00 15.44 ? 95  GLN   A N    1 
ATOM   1254 C  CA   . GLN   A 1 115 ? -14.825 20.529 11.337 1.00 18.21 ? 95  GLN   A CA   1 
ATOM   1255 C  C    . GLN   A 1 115 ? -13.860 21.351 10.494 1.00 18.42 ? 95  GLN   A C    1 
ATOM   1256 O  O    . GLN   A 1 115 ? -14.255 21.861 9.442  1.00 17.21 ? 95  GLN   A O    1 
ATOM   1257 C  CB   . GLN   A 1 115 ? -15.809 21.432 12.091 1.00 15.51 ? 95  GLN   A CB   1 
ATOM   1258 C  CG   . GLN   A 1 115 ? -15.189 22.530 12.929 1.00 14.76 ? 95  GLN   A CG   1 
ATOM   1259 C  CD   . GLN   A 1 115 ? -14.910 22.114 14.365 1.00 19.69 ? 95  GLN   A CD   1 
ATOM   1260 O  OE1  . GLN   A 1 115 ? -14.663 20.944 14.658 1.00 17.84 ? 95  GLN   A OE1  1 
ATOM   1261 N  NE2  . GLN   A 1 115 ? -14.948 23.082 15.269 1.00 23.70 ? 95  GLN   A NE2  1 
ATOM   1262 H  H    . GLN   A 1 115 ? -14.253 19.861 13.108 1.00 18.55 ? 95  GLN   A H    1 
ATOM   1263 H  HA   . GLN   A 1 115 ? -15.340 19.971 10.734 1.00 21.87 ? 95  GLN   A HA   1 
ATOM   1264 H  HB2  . GLN   A 1 115 ? -16.392 21.857 11.443 1.00 18.63 ? 95  GLN   A HB2  1 
ATOM   1265 H  HB3  . GLN   A 1 115 ? -16.338 20.878 12.686 1.00 18.63 ? 95  GLN   A HB3  1 
ATOM   1266 H  HG2  . GLN   A 1 115 ? -14.349 22.811 12.536 1.00 17.73 ? 95  GLN   A HG2  1 
ATOM   1267 H  HG3  . GLN   A 1 115 ? -15.802 23.281 12.956 1.00 17.73 ? 95  GLN   A HG3  1 
ATOM   1268 H  HE21 . GLN   A 1 115 ? -15.124 23.889 15.028 1.00 28.45 ? 95  GLN   A HE21 1 
ATOM   1269 H  HE22 . GLN   A 1 115 ? -14.798 22.903 16.097 1.00 28.45 ? 95  GLN   A HE22 1 
ATOM   1270 N  N    . ASP   A 1 116 ? -12.609 21.478 10.937 1.00 15.73 ? 96  ASP   A N    1 
ATOM   1271 C  CA   . ASP   A 1 116 ? -11.545 22.110 10.167 1.00 16.66 ? 96  ASP   A CA   1 
ATOM   1272 C  C    . ASP   A 1 116 ? -10.848 21.014 9.375  1.00 16.14 ? 96  ASP   A C    1 
ATOM   1273 O  O    . ASP   A 1 116 ? -10.220 20.136 9.984  1.00 14.57 ? 96  ASP   A O    1 
ATOM   1274 C  CB   . ASP   A 1 116 ? -10.570 22.805 11.109 1.00 18.60 ? 96  ASP   A CB   1 
ATOM   1275 C  CG   . ASP   A 1 116 ? -9.505  23.606 10.391 1.00 19.95 ? 96  ASP   A CG   1 
ATOM   1276 O  OD1  . ASP   A 1 116 ? -9.283  23.404 9.179  1.00 18.47 ? 96  ASP   A OD1  1 
ATOM   1277 O  OD2  . ASP   A 1 116 ? -8.879  24.447 11.076 1.00 19.44 ? 96  ASP   A OD2  1 
ATOM   1278 H  H    . ASP   A 1 116 ? -12.347 21.197 11.706 1.00 18.89 ? 96  ASP   A H    1 
ATOM   1279 H  HA   . ASP   A 1 116 ? -11.921 22.770 9.566  1.00 20.00 ? 96  ASP   A HA   1 
ATOM   1280 H  HB2  . ASP   A 1 116 ? -11.065 23.413 11.680 1.00 22.34 ? 96  ASP   A HB2  1 
ATOM   1281 H  HB3  . ASP   A 1 116 ? -10.124 22.134 11.650 1.00 22.34 ? 96  ASP   A HB3  1 
ATOM   1282 N  N    . PRO   A 1 117 ? -10.949 20.991 8.044  1.00 16.28 ? 97  PRO   A N    1 
ATOM   1283 C  CA   . PRO   A 1 117 ? -10.280 19.917 7.291  1.00 14.90 ? 97  PRO   A CA   1 
ATOM   1284 C  C    . PRO   A 1 117 ? -8.778  19.920 7.475  1.00 14.72 ? 97  PRO   A C    1 
ATOM   1285 O  O    . PRO   A 1 117 ? -8.129  18.919 7.148  1.00 14.98 ? 97  PRO   A O    1 
ATOM   1286 C  CB   . PRO   A 1 117 ? -10.668 20.200 5.836  1.00 20.99 ? 97  PRO   A CB   1 
ATOM   1287 C  CG   . PRO   A 1 117 ? -10.950 21.653 5.799  1.00 21.01 ? 97  PRO   A CG   1 
ATOM   1288 C  CD   . PRO   A 1 117 ? -11.549 21.998 7.142  1.00 20.12 ? 97  PRO   A CD   1 
ATOM   1289 H  HA   . PRO   A 1 117 ? -10.633 19.053 7.554  1.00 17.90 ? 97  PRO   A HA   1 
ATOM   1290 H  HB2  . PRO   A 1 117 ? -9.928  19.978 5.250  1.00 25.20 ? 97  PRO   A HB2  1 
ATOM   1291 H  HB3  . PRO   A 1 117 ? -11.459 19.690 5.602  1.00 25.20 ? 97  PRO   A HB3  1 
ATOM   1292 H  HG2  . PRO   A 1 117 ? -10.123 22.140 5.660  1.00 25.24 ? 97  PRO   A HG2  1 
ATOM   1293 H  HG3  . PRO   A 1 117 ? -11.580 21.843 5.087  1.00 25.24 ? 97  PRO   A HG3  1 
ATOM   1294 H  HD2  . PRO   A 1 117 ? -11.286 22.893 7.408  1.00 24.17 ? 97  PRO   A HD2  1 
ATOM   1295 H  HD3  . PRO   A 1 117 ? -12.514 21.901 7.118  1.00 24.17 ? 97  PRO   A HD3  1 
ATOM   1296 N  N    . ASN   A 1 118 ? -8.210  21.002 8.003  1.00 14.56 ? 98  ASN   A N    1 
ATOM   1297 C  CA   . ASN   A 1 118 ? -6.773  21.118 8.203  1.00 15.58 ? 98  ASN   A CA   1 
ATOM   1298 C  C    . ASN   A 1 118 ? -6.361  20.939 9.655  1.00 13.72 ? 98  ASN   A C    1 
ATOM   1299 O  O    . ASN   A 1 118 ? -5.218  21.259 10.004 1.00 17.28 ? 98  ASN   A O    1 
ATOM   1300 C  CB   . ASN   A 1 118 ? -6.293  22.470 7.680  1.00 16.44 ? 98  ASN   A CB   1 
ATOM   1301 C  CG   . ASN   A 1 118 ? -6.366  22.559 6.169  1.00 19.62 ? 98  ASN   A CG   1 
ATOM   1302 O  OD1  . ASN   A 1 118 ? -5.844  21.696 5.465  1.00 21.33 ? 98  ASN   A OD1  1 
ATOM   1303 N  ND2  . ASN   A 1 118 ? -7.032  23.591 5.661  1.00 25.25 ? 98  ASN   A ND2  1 
ATOM   1304 H  H    . ASN   A 1 118 ? -8.646  21.698 8.256  1.00 17.49 ? 98  ASN   A H    1 
ATOM   1305 H  HA   . ASN   A 1 118 ? -6.328  20.429 7.685  1.00 18.71 ? 98  ASN   A HA   1 
ATOM   1306 H  HB2  . ASN   A 1 118 ? -6.852  23.171 8.051  1.00 19.74 ? 98  ASN   A HB2  1 
ATOM   1307 H  HB3  . ASN   A 1 118 ? -5.370  22.605 7.945  1.00 19.74 ? 98  ASN   A HB3  1 
ATOM   1308 H  HD21 . ASN   A 1 118 ? -7.101  23.681 4.808  1.00 30.32 ? 98  ASN   A HD21 1 
ATOM   1309 H  HD22 . ASN   A 1 118 ? -7.387  24.173 6.185  1.00 30.32 ? 98  ASN   A HD22 1 
ATOM   1310 N  N    . TRP   A 1 119 ? -7.239  20.414 10.507 1.00 15.29 ? 99  TRP   A N    1 
ATOM   1311 C  CA   . TRP   A 1 119 ? -6.909  20.206 11.914 1.00 13.74 ? 99  TRP   A CA   1 
ATOM   1312 C  C    . TRP   A 1 119 ? -7.394  18.835 12.347 1.00 14.15 ? 99  TRP   A C    1 
ATOM   1313 O  O    . TRP   A 1 119 ? -8.594  18.545 12.275 1.00 16.75 ? 99  TRP   A O    1 
ATOM   1314 C  CB   . TRP   A 1 119 ? -7.537  21.289 12.798 1.00 15.93 ? 99  TRP   A CB   1 
ATOM   1315 C  CG   . TRP   A 1 119 ? -6.848  21.521 14.123 1.00 14.29 ? 99  TRP   A CG   1 
ATOM   1316 C  CD1  . TRP   A 1 119 ? -6.141  20.616 14.867 1.00 14.07 ? 99  TRP   A CD1  1 
ATOM   1317 C  CD2  . TRP   A 1 119 ? -6.802  22.753 14.841 1.00 14.25 ? 99  TRP   A CD2  1 
ATOM   1318 N  NE1  . TRP   A 1 119 ? -5.653  21.218 16.003 1.00 13.12 ? 99  TRP   A NE1  1 
ATOM   1319 C  CE2  . TRP   A 1 119 ? -6.048  22.532 16.010 1.00 11.29 ? 99  TRP   A CE2  1 
ATOM   1320 C  CE3  . TRP   A 1 119 ? -7.323  24.029 14.605 1.00 16.36 ? 99  TRP   A CE3  1 
ATOM   1321 C  CZ2  . TRP   A 1 119 ? -5.813  23.538 16.946 1.00 16.49 ? 99  TRP   A CZ2  1 
ATOM   1322 C  CZ3  . TRP   A 1 119 ? -7.085  25.024 15.533 1.00 17.51 ? 99  TRP   A CZ3  1 
ATOM   1323 C  CH2  . TRP   A 1 119 ? -6.338  24.772 16.688 1.00 18.29 ? 99  TRP   A CH2  1 
ATOM   1324 H  H    . TRP   A 1 119 ? -8.035  20.169 10.294 1.00 18.36 ? 99  TRP   A H    1 
ATOM   1325 H  HA   . TRP   A 1 119 ? -5.947  20.239 12.030 1.00 16.51 ? 99  TRP   A HA   1 
ATOM   1326 H  HB2  . TRP   A 1 119 ? -7.524  22.128 12.312 1.00 19.14 ? 99  TRP   A HB2  1 
ATOM   1327 H  HB3  . TRP   A 1 119 ? -8.455  21.038 12.987 1.00 19.14 ? 99  TRP   A HB3  1 
ATOM   1328 H  HD1  . TRP   A 1 119 ? -6.002  19.727 14.633 1.00 16.90 ? 99  TRP   A HD1  1 
ATOM   1329 H  HE1  . TRP   A 1 119 ? -5.185  20.832 16.613 1.00 15.77 ? 99  TRP   A HE1  1 
ATOM   1330 H  HE3  . TRP   A 1 119 ? -7.821  24.204 13.839 1.00 19.65 ? 99  TRP   A HE3  1 
ATOM   1331 H  HZ2  . TRP   A 1 119 ? -5.316  23.376 17.715 1.00 19.81 ? 99  TRP   A HZ2  1 
ATOM   1332 H  HZ3  . TRP   A 1 119 ? -7.428  25.876 15.388 1.00 21.03 ? 99  TRP   A HZ3  1 
ATOM   1333 H  HH2  . TRP   A 1 119 ? -6.194  25.462 17.294 1.00 21.97 ? 99  TRP   A HH2  1 
ATOM   1334 N  N    . PHE   A 1 120 ? -6.461  18.015 12.822 1.00 13.22 ? 100 PHE   A N    1 
ATOM   1335 C  CA   . PHE   A 1 120 ? -6.748  16.683 13.327 1.00 11.79 ? 100 PHE   A CA   1 
ATOM   1336 C  C    . PHE   A 1 120 ? -6.217  16.559 14.747 1.00 12.84 ? 100 PHE   A C    1 
ATOM   1337 O  O    . PHE   A 1 120 ? -5.260  17.240 15.128 1.00 15.05 ? 100 PHE   A O    1 
ATOM   1338 C  CB   . PHE   A 1 120 ? -6.087  15.586 12.465 1.00 13.09 ? 100 PHE   A CB   1 
ATOM   1339 C  CG   . PHE   A 1 120 ? -6.711  15.402 11.118 1.00 15.08 ? 100 PHE   A CG   1 
ATOM   1340 C  CD1  . PHE   A 1 120 ? -6.621  16.385 10.147 1.00 22.26 ? 100 PHE   A CD1  1 
ATOM   1341 C  CD2  . PHE   A 1 120 ? -7.379  14.233 10.822 1.00 15.28 ? 100 PHE   A CD2  1 
ATOM   1342 C  CE1  . PHE   A 1 120 ? -7.203  16.205 8.914  1.00 19.27 ? 100 PHE   A CE1  1 
ATOM   1343 C  CE2  . PHE   A 1 120 ? -7.947  14.042 9.589  1.00 15.97 ? 100 PHE   A CE2  1 
ATOM   1344 C  CZ   . PHE   A 1 120 ? -7.865  15.030 8.633  1.00 16.01 ? 100 PHE   A CZ   1 
ATOM   1345 H  H    . PHE   A 1 120 ? -5.626  18.219 12.862 1.00 15.89 ? 100 PHE   A H    1 
ATOM   1346 H  HA   . PHE   A 1 120 ? -7.706  16.534 13.339 1.00 14.17 ? 100 PHE   A HA   1 
ATOM   1347 H  HB2  . PHE   A 1 120 ? -5.155  15.817 12.329 1.00 15.73 ? 100 PHE   A HB2  1 
ATOM   1348 H  HB3  . PHE   A 1 120 ? -6.149  14.741 12.937 1.00 15.73 ? 100 PHE   A HB3  1 
ATOM   1349 H  HD1  . PHE   A 1 120 ? -6.177  17.180 10.336 1.00 26.73 ? 100 PHE   A HD1  1 
ATOM   1350 H  HD2  . PHE   A 1 120 ? -7.439  13.563 11.464 1.00 18.35 ? 100 PHE   A HD2  1 
ATOM   1351 H  HE1  . PHE   A 1 120 ? -7.140  16.870 8.267  1.00 23.14 ? 100 PHE   A HE1  1 
ATOM   1352 H  HE2  . PHE   A 1 120 ? -8.399  13.251 9.403  1.00 19.19 ? 100 PHE   A HE2  1 
ATOM   1353 H  HZ   . PHE   A 1 120 ? -8.254  14.903 7.798  1.00 19.22 ? 100 PHE   A HZ   1 
ATOM   1354 N  N    . TRP   A 1 121 ? -6.833  15.672 15.523 1.00 11.46 ? 101 TRP   A N    1 
ATOM   1355 C  CA   . TRP   A 1 121 ? -6.321  15.267 16.823 1.00 10.23 ? 101 TRP   A CA   1 
ATOM   1356 C  C    . TRP   A 1 121 ? -6.147  13.756 16.800 1.00 13.76 ? 101 TRP   A C    1 
ATOM   1357 O  O    . TRP   A 1 121 ? -6.878  13.043 16.102 1.00 15.74 ? 101 TRP   A O    1 
ATOM   1358 C  CB   . TRP   A 1 121 ? -7.260  15.665 17.974 1.00 10.39 ? 101 TRP   A CB   1 
ATOM   1359 C  CG   . TRP   A 1 121 ? -7.276  17.137 18.187 1.00 12.53 ? 101 TRP   A CG   1 
ATOM   1360 C  CD1  . TRP   A 1 121 ? -8.051  18.051 17.531 1.00 13.91 ? 101 TRP   A CD1  1 
ATOM   1361 C  CD2  . TRP   A 1 121 ? -6.461  17.877 19.093 1.00 11.21 ? 101 TRP   A CD2  1 
ATOM   1362 N  NE1  . TRP   A 1 121 ? -7.767  19.319 17.977 1.00 14.49 ? 101 TRP   A NE1  1 
ATOM   1363 C  CE2  . TRP   A 1 121 ? -6.797  19.239 18.942 1.00 10.80 ? 101 TRP   A CE2  1 
ATOM   1364 C  CE3  . TRP   A 1 121 ? -5.479  17.523 20.026 1.00 11.36 ? 101 TRP   A CE3  1 
ATOM   1365 C  CZ2  . TRP   A 1 121 ? -6.187  20.243 19.688 1.00 12.23 ? 101 TRP   A CZ2  1 
ATOM   1366 C  CZ3  . TRP   A 1 121 ? -4.884  18.517 20.765 1.00 12.19 ? 101 TRP   A CZ3  1 
ATOM   1367 C  CH2  . TRP   A 1 121 ? -5.240  19.862 20.593 1.00 12.17 ? 101 TRP   A CH2  1 
ATOM   1368 H  H    . TRP   A 1 121 ? -7.569  15.282 15.310 1.00 13.77 ? 101 TRP   A H    1 
ATOM   1369 H  HA   . TRP   A 1 121 ? -5.456  15.677 16.973 1.00 12.30 ? 101 TRP   A HA   1 
ATOM   1370 H  HB2  . TRP   A 1 121 ? -8.163  15.379 17.763 1.00 12.49 ? 101 TRP   A HB2  1 
ATOM   1371 H  HB3  . TRP   A 1 121 ? -6.958  15.243 18.793 1.00 12.49 ? 101 TRP   A HB3  1 
ATOM   1372 H  HD1  . TRP   A 1 121 ? -8.672  17.846 16.870 1.00 16.71 ? 101 TRP   A HD1  1 
ATOM   1373 H  HE1  . TRP   A 1 121 ? -8.143  20.042 17.703 1.00 17.41 ? 101 TRP   A HE1  1 
ATOM   1374 H  HE3  . TRP   A 1 121 ? -5.238  16.633 20.147 1.00 13.65 ? 101 TRP   A HE3  1 
ATOM   1375 H  HZ2  . TRP   A 1 121 ? -6.422  21.136 19.581 1.00 14.69 ? 101 TRP   A HZ2  1 
ATOM   1376 H  HZ3  . TRP   A 1 121 ? -4.230  18.294 21.387 1.00 14.64 ? 101 TRP   A HZ3  1 
ATOM   1377 H  HH2  . TRP   A 1 121 ? -4.816  20.512 21.106 1.00 14.62 ? 101 TRP   A HH2  1 
ATOM   1378 N  N    . VAL   A 1 122 ? -5.183  13.271 17.571 1.00 12.17 ? 102 VAL   A N    1 
ATOM   1379 C  CA   . VAL   A 1 122 ? -4.931  11.842 17.695 1.00 12.46 ? 102 VAL   A CA   1 
ATOM   1380 C  C    . VAL   A 1 122 ? -4.810  11.505 19.171 1.00 12.40 ? 102 VAL   A C    1 
ATOM   1381 O  O    . VAL   A 1 122 ? -4.060  12.162 19.899 1.00 13.47 ? 102 VAL   A O    1 
ATOM   1382 C  CB   . VAL   A 1 122 ? -3.648  11.422 16.945 1.00 11.97 ? 102 VAL   A CB   1 
ATOM   1383 C  CG1  . VAL   A 1 122 ? -3.390  9.944  17.154 1.00 12.43 ? 102 VAL   A CG1  1 
ATOM   1384 C  CG2  . VAL   A 1 122 ? -3.755  11.751 15.459 1.00 15.39 ? 102 VAL   A CG2  1 
ATOM   1385 H  H    . VAL   A 1 122 ? -4.652  13.758 18.041 1.00 14.62 ? 102 VAL   A H    1 
ATOM   1386 H  HA   . VAL   A 1 122 ? -5.678  11.346 17.327 1.00 14.97 ? 102 VAL   A HA   1 
ATOM   1387 H  HB   . VAL   A 1 122 ? -2.895  11.910 17.308 1.00 14.38 ? 102 VAL   A HB   1 
ATOM   1388 H  HG11 . VAL   A 1 122 ? -2.741  9.643  16.499 1.00 14.94 ? 102 VAL   A HG11 1 
ATOM   1389 H  HG12 . VAL   A 1 122 ? -3.043  9.804  18.049 1.00 14.94 ? 102 VAL   A HG12 1 
ATOM   1390 H  HG13 . VAL   A 1 122 ? -4.222  9.459  17.040 1.00 14.94 ? 102 VAL   A HG13 1 
ATOM   1391 H  HG21 . VAL   A 1 122 ? -2.947  11.456 15.012 1.00 18.49 ? 102 VAL   A HG21 1 
ATOM   1392 H  HG22 . VAL   A 1 122 ? -4.525  11.291 15.089 1.00 18.49 ? 102 VAL   A HG22 1 
ATOM   1393 H  HG23 . VAL   A 1 122 ? -3.860  12.710 15.354 1.00 18.49 ? 102 VAL   A HG23 1 
ATOM   1394 N  N    . GLU   A 1 123 ? -5.561  10.503 19.616 1.00 11.10 ? 103 GLU   A N    1 
ATOM   1395 C  CA   . GLU   A 1 123 ? -5.354  9.910  20.930 1.00 10.26 ? 103 GLU   A CA   1 
ATOM   1396 C  C    . GLU   A 1 123 ? -4.624  8.589  20.729 1.00 13.64 ? 103 GLU   A C    1 
ATOM   1397 O  O    . GLU   A 1 123 ? -5.001  7.794  19.862 1.00 13.34 ? 103 GLU   A O    1 
ATOM   1398 C  CB   . GLU   A 1 123 ? -6.662  9.682  21.681 1.00 10.95 ? 103 GLU   A CB   1 
ATOM   1399 C  CG   . GLU   A 1 123 ? -6.402  9.138  23.080 1.00 13.85 ? 103 GLU   A CG   1 
ATOM   1400 C  CD   . GLU   A 1 123 ? -7.635  9.018  23.956 1.00 15.79 ? 103 GLU   A CD   1 
ATOM   1401 O  OE1  . GLU   A 1 123 ? -8.778  9.151  23.456 1.00 14.42 ? 103 GLU   A OE1  1 
ATOM   1402 O  OE2  . GLU   A 1 123 ? -7.444  8.771  25.168 1.00 17.31 ? 103 GLU   A OE2  1 
ATOM   1403 H  H    . GLU   A 1 123 ? -6.204  10.146 19.170 1.00 13.34 ? 103 GLU   A H    1 
ATOM   1404 H  HA   . GLU   A 1 123 ? -4.792  10.492 21.466 1.00 12.33 ? 103 GLU   A HA   1 
ATOM   1405 H  HB2  . GLU   A 1 123 ? -7.136  10.524 21.764 1.00 13.16 ? 103 GLU   A HB2  1 
ATOM   1406 H  HB3  . GLU   A 1 123 ? -7.202  9.037  21.198 1.00 13.16 ? 103 GLU   A HB3  1 
ATOM   1407 H  HG2  . GLU   A 1 123 ? -6.014  8.252  23.003 1.00 16.63 ? 103 GLU   A HG2  1 
ATOM   1408 H  HG3  . GLU   A 1 123 ? -5.778  9.729  23.531 1.00 16.63 ? 103 GLU   A HG3  1 
ATOM   1409 N  N    . CYS   A 1 124 ? -3.588  8.358  21.518 1.00 14.21 ? 104 CYS   A N    1 
ATOM   1410 C  CA   . CYS   A 1 124 ? -2.823  7.129  21.365 1.00 13.00 ? 104 CYS   A CA   1 
ATOM   1411 C  C    . CYS   A 1 124 ? -2.014  6.881  22.628 1.00 13.89 ? 104 CYS   A C    1 
ATOM   1412 O  O    . CYS   A 1 124 ? -2.022  7.679  23.570 1.00 13.96 ? 104 CYS   A O    1 
ATOM   1413 C  CB   . CYS   A 1 124 ? -1.914  7.201  20.136 1.00 13.46 ? 104 CYS   A CB   1 
ATOM   1414 S  SG   . CYS   A 1 124 ? -0.562  8.374  20.321 1.00 14.46 ? 104 CYS   A SG   1 
ATOM   1415 H  H    . CYS   A 1 124 ? -3.310  8.884  22.139 1.00 17.07 ? 104 CYS   A H    1 
ATOM   1416 H  HA   . CYS   A 1 124 ? -3.434  6.385  21.246 1.00 15.62 ? 104 CYS   A HA   1 
ATOM   1417 H  HB2  . CYS   A 1 124 ? -1.528  6.326  19.977 1.00 16.17 ? 104 CYS   A HB2  1 
ATOM   1418 H  HB3  . CYS   A 1 124 ? -2.442  7.473  19.369 1.00 16.17 ? 104 CYS   A HB3  1 
ATOM   1419 H  HG   . CYS   A 1 124 ? 0.179   8.261  19.386 1.00 17.37 ? 104 CYS   A HG   1 
ATOM   1420 N  N    . ARG   A 1 125 ? -1.338  5.745  22.649 1.00 12.33 ? 105 ARG   A N    1 
ATOM   1421 C  CA   . ARG   A 1 125 ? -0.286  5.475  23.613 1.00 10.35 ? 105 ARG   A CA   1 
ATOM   1422 C  C    . ARG   A 1 125 ? 1.023   5.374  22.851 1.00 11.80 ? 105 ARG   A C    1 
ATOM   1423 O  O    . ARG   A 1 125 ? 1.041   5.233  21.623 1.00 14.47 ? 105 ARG   A O    1 
ATOM   1424 C  CB   . ARG   A 1 125 ? -0.575  4.201  24.399 1.00 16.16 ? 105 ARG   A CB   1 
ATOM   1425 C  CG   . ARG   A 1 125 ? -1.805  4.359  25.295 1.00 18.34 ? 105 ARG   A CG   1 
ATOM   1426 C  CD   . ARG   A 1 125 ? -1.992  3.167  26.198 1.00 28.33 ? 105 ARG   A CD   1 
ATOM   1427 N  NE   . ARG   A 1 125 ? -2.146  1.943  25.423 1.00 26.98 ? 105 ARG   A NE   1 
ATOM   1428 C  CZ   . ARG   A 1 125 ? -2.176  0.726  25.945 1.00 33.58 ? 105 ARG   A CZ   1 
ATOM   1429 N  NH1  . ARG   A 1 125 ? -2.096  0.533  27.253 1.00 29.65 ? 105 ARG   A NH1  1 
ATOM   1430 N  NH2  . ARG   A 1 125 ? -2.286  -0.323 25.135 1.00 27.98 ? 105 ARG   A NH2  1 
ATOM   1431 H  H    . ARG   A 1 125 ? -1.474  5.097  22.100 1.00 14.82 ? 105 ARG   A H    1 
ATOM   1432 H  HA   . ARG   A 1 125 ? -0.220  6.213  24.239 1.00 12.44 ? 105 ARG   A HA   1 
ATOM   1433 H  HB2  . ARG   A 1 125 ? -0.742  3.474  23.779 1.00 19.40 ? 105 ARG   A HB2  1 
ATOM   1434 H  HB3  . ARG   A 1 125 ? 0.187   3.993  24.963 1.00 19.40 ? 105 ARG   A HB3  1 
ATOM   1435 H  HG2  . ARG   A 1 125 ? -1.697  5.147  25.851 1.00 22.02 ? 105 ARG   A HG2  1 
ATOM   1436 H  HG3  . ARG   A 1 125 ? -2.596  4.446  24.740 1.00 22.02 ? 105 ARG   A HG3  1 
ATOM   1437 H  HD2  . ARG   A 1 125 ? -1.214  3.071  26.769 1.00 34.01 ? 105 ARG   A HD2  1 
ATOM   1438 H  HD3  . ARG   A 1 125 ? -2.791  3.292  26.734 1.00 34.01 ? 105 ARG   A HD3  1 
ATOM   1439 H  HE   . ARG   A 1 125 ? -2.232  2.016  24.570 1.00 32.39 ? 105 ARG   A HE   1 
ATOM   1440 H  HH11 . ARG   A 1 125 ? -2.023  1.204  27.786 1.00 35.59 ? 105 ARG   A HH11 1 
ATOM   1441 H  HH12 . ARG   A 1 125 ? -2.118  -0.266 27.571 1.00 35.59 ? 105 ARG   A HH12 1 
ATOM   1442 H  HH21 . ARG   A 1 125 ? -2.339  -0.206 24.285 1.00 33.59 ? 105 ARG   A HH21 1 
ATOM   1443 H  HH22 . ARG   A 1 125 ? -2.308  -1.118 25.462 1.00 33.59 ? 105 ARG   A HH22 1 
ATOM   1444 N  N    . GLY   A 1 126 ? 2.117   5.493  23.581 1.00 14.93 ? 106 GLY   A N    1 
ATOM   1445 C  CA   . GLY   A 1 126 ? 3.434   5.339  22.996 1.00 12.25 ? 106 GLY   A CA   1 
ATOM   1446 C  C    . GLY   A 1 126 ? 4.328   4.615  23.972 1.00 13.16 ? 106 GLY   A C    1 
ATOM   1447 O  O    . GLY   A 1 126 ? 4.186   4.752  25.190 1.00 14.76 ? 106 GLY   A O    1 
ATOM   1448 H  H    . GLY   A 1 126 ? 2.124   5.664  24.424 1.00 17.94 ? 106 GLY   A H    1 
ATOM   1449 H  HA2  . GLY   A 1 126 ? 3.378   4.824  22.176 1.00 14.72 ? 106 GLY   A HA2  1 
ATOM   1450 H  HA3  . GLY   A 1 126 ? 3.815   6.209  22.799 1.00 14.72 ? 106 GLY   A HA3  1 
ATOM   1451 N  N    . GLU   A 1 127 ? 5.253   3.827  23.427 1.00 15.23 ? 107 GLU   A N    1 
ATOM   1452 C  CA   . GLU   A 1 127 ? 6.141   3.092  24.310 1.00 16.44 ? 107 GLU   A CA   1 
ATOM   1453 C  C    . GLU   A 1 127 ? 7.445   2.725  23.626 1.00 13.07 ? 107 GLU   A C    1 
ATOM   1454 O  O    . GLU   A 1 127 ? 7.510   2.586  22.402 1.00 15.75 ? 107 GLU   A O    1 
ATOM   1455 C  CB   . GLU   A 1 127 ? 5.475   1.813  24.828 1.00 17.36 ? 107 GLU   A CB   1 
ATOM   1456 C  CG   . GLU   A 1 127 ? 5.130   0.814  23.739 1.00 21.94 ? 107 GLU   A CG   1 
ATOM   1457 C  CD   . GLU   A 1 127 ? 4.604   -0.471 24.319 1.00 31.31 ? 107 GLU   A CD   1 
ATOM   1458 O  OE1  . GLU   A 1 127 ? 5.433   -1.302 24.745 1.00 33.01 ? 107 GLU   A OE1  1 
ATOM   1459 O  OE2  . GLU   A 1 127 ? 3.367   -0.628 24.394 1.00 27.29 ? 107 GLU   A OE2  1 
ATOM   1460 H  H    . GLU   A 1 127 ? 5.381   3.706  22.585 1.00 18.30 ? 107 GLU   A H    1 
ATOM   1461 H  HA   . GLU   A 1 127 ? 6.353   3.649  25.074 1.00 19.74 ? 107 GLU   A HA   1 
ATOM   1462 H  HB2  . GLU   A 1 127 ? 6.079   1.377  25.449 1.00 20.86 ? 107 GLU   A HB2  1 
ATOM   1463 H  HB3  . GLU   A 1 127 ? 4.652   2.052  25.282 1.00 20.86 ? 107 GLU   A HB3  1 
ATOM   1464 H  HG2  . GLU   A 1 127 ? 4.445   1.191  23.164 1.00 26.34 ? 107 GLU   A HG2  1 
ATOM   1465 H  HG3  . GLU   A 1 127 ? 5.924   0.606  23.223 1.00 26.34 ? 107 GLU   A HG3  1 
ATOM   1466 N  N    . GLY   A 1 128 ? 8.471   2.532  24.451 1.00 14.60 ? 108 GLY   A N    1 
ATOM   1467 C  CA   . GLY   A 1 128 ? 9.763   2.107  23.956 1.00 16.68 ? 108 GLY   A CA   1 
ATOM   1468 C  C    . GLY   A 1 128 ? 10.817  2.320  25.016 1.00 17.26 ? 108 GLY   A C    1 
ATOM   1469 O  O    . GLY   A 1 128 ? 10.566  2.890  26.087 1.00 18.01 ? 108 GLY   A O    1 
ATOM   1470 H  H    . GLY   A 1 128 ? 8.439   2.642  25.303 1.00 17.53 ? 108 GLY   A H    1 
ATOM   1471 H  HA2  . GLY   A 1 128 ? 9.735   1.166  23.724 1.00 20.03 ? 108 GLY   A HA2  1 
ATOM   1472 H  HA3  . GLY   A 1 128 ? 10.001  2.620  23.168 1.00 20.03 ? 108 GLY   A HA3  1 
ATOM   1473 N  N    . ALA   A 1 129 ? 12.012  1.831  24.710 1.00 14.84 ? 109 ALA   A N    1 
ATOM   1474 C  CA   . ALA   A 1 129 ? 13.156  2.130  25.558 1.00 16.88 ? 109 ALA   A CA   1 
ATOM   1475 C  C    . ALA   A 1 129 ? 13.395  3.635  25.577 1.00 15.53 ? 109 ALA   A C    1 
ATOM   1476 O  O    . ALA   A 1 129 ? 13.156  4.335  24.591 1.00 18.59 ? 109 ALA   A O    1 
ATOM   1477 C  CB   . ALA   A 1 129 ? 14.393  1.402  25.045 1.00 18.36 ? 109 ALA   A CB   1 
ATOM   1478 H  H    . ALA   A 1 129 ? 12.185  1.333  24.030 1.00 17.82 ? 109 ALA   A H    1 
ATOM   1479 H  HA   . ALA   A 1 129 ? 12.976  1.834  26.464 1.00 20.27 ? 109 ALA   A HA   1 
ATOM   1480 H  HB1  . ALA   A 1 129 ? 15.144  1.613  25.621 1.00 22.05 ? 109 ALA   A HB1  1 
ATOM   1481 H  HB2  . ALA   A 1 129 ? 14.224  0.447  25.056 1.00 22.05 ? 109 ALA   A HB2  1 
ATOM   1482 H  HB3  . ALA   A 1 129 ? 14.578  1.695  24.139 1.00 22.05 ? 109 ALA   A HB3  1 
ATOM   1483 N  N    . ILE   A 1 130 ? 13.865  4.142  26.712 1.00 16.13 ? 110 ILE   A N    1 
ATOM   1484 C  CA   . ILE   A 1 130 ? 14.290  5.533  26.817 1.00 17.53 ? 110 ILE   A CA   1 
ATOM   1485 C  C    . ILE   A 1 130 ? 15.755  5.537  27.218 1.00 19.40 ? 110 ILE   A C    1 
ATOM   1486 O  O    . ILE   A 1 130 ? 16.136  4.930  28.226 1.00 17.91 ? 110 ILE   A O    1 
ATOM   1487 C  CB   . ILE   A 1 130 ? 13.420  6.337  27.795 1.00 15.75 ? 110 ILE   A CB   1 
ATOM   1488 C  CG1  . ILE   A 1 130 ? 13.865  7.806  27.831 1.00 17.54 ? 110 ILE   A CG1  1 
ATOM   1489 C  CG2  . ILE   A 1 130 ? 13.443  5.744  29.195 1.00 20.23 ? 110 ILE   A CG2  1 
ATOM   1490 C  CD1  . ILE   A 1 130 ? 12.873  8.720  28.546 1.00 19.06 ? 110 ILE   A CD1  1 
ATOM   1491 H  H    . ILE   A 1 130 ? 13.949  3.696  27.442 1.00 19.37 ? 110 ILE   A H    1 
ATOM   1492 H  HA   . ILE   A 1 130 ? 14.221  5.954  25.946 1.00 21.05 ? 110 ILE   A HA   1 
ATOM   1493 H  HB   . ILE   A 1 130 ? 12.505  6.309  27.474 1.00 18.92 ? 110 ILE   A HB   1 
ATOM   1494 H  HG12 . ILE   A 1 130 ? 14.714  7.867  28.297 1.00 21.06 ? 110 ILE   A HG12 1 
ATOM   1495 H  HG13 . ILE   A 1 130 ? 13.964  8.127  26.921 1.00 21.06 ? 110 ILE   A HG13 1 
ATOM   1496 H  HG21 . ILE   A 1 130 ? 12.780  6.195  29.740 1.00 24.29 ? 110 ILE   A HG21 1 
ATOM   1497 H  HG22 . ILE   A 1 130 ? 13.236  4.798  29.141 1.00 24.29 ? 110 ILE   A HG22 1 
ATOM   1498 H  HG23 . ILE   A 1 130 ? 14.325  5.869  29.578 1.00 24.29 ? 110 ILE   A HG23 1 
ATOM   1499 H  HD11 . ILE   A 1 130 ? 13.172  9.639  28.459 1.00 22.88 ? 110 ILE   A HD11 1 
ATOM   1500 H  HD12 . ILE   A 1 130 ? 11.999  8.616  28.139 1.00 22.88 ? 110 ILE   A HD12 1 
ATOM   1501 H  HD13 . ILE   A 1 130 ? 12.833  8.473  29.483 1.00 22.88 ? 110 ILE   A HD13 1 
ATOM   1502 N  N    . VAL   A 1 131 ? 16.577  6.195  26.405 1.00 16.85 ? 111 VAL   A N    1 
ATOM   1503 C  CA   . VAL   A 1 131 ? 18.023  6.202  26.574 1.00 15.83 ? 111 VAL   A CA   1 
ATOM   1504 C  C    . VAL   A 1 131 ? 18.483  7.652  26.593 1.00 17.74 ? 111 VAL   A C    1 
ATOM   1505 O  O    . VAL   A 1 131 ? 19.036  8.154  25.606 1.00 20.69 ? 111 VAL   A O    1 
ATOM   1506 C  CB   . VAL   A 1 131 ? 18.721  5.417  25.449 1.00 19.30 ? 111 VAL   A CB   1 
ATOM   1507 C  CG1  . VAL   A 1 131 ? 20.205  5.293  25.743 1.00 24.61 ? 111 VAL   A CG1  1 
ATOM   1508 C  CG2  . VAL   A 1 131 ? 18.080  4.041  25.277 1.00 20.46 ? 111 VAL   A CG2  1 
ATOM   1509 H  H    . VAL   A 1 131 ? 16.311  6.657  25.730 1.00 20.24 ? 111 VAL   A H    1 
ATOM   1510 H  HA   . VAL   A 1 131 ? 18.255  5.795  27.423 1.00 19.01 ? 111 VAL   A HA   1 
ATOM   1511 H  HB   . VAL   A 1 131 ? 18.619  5.901  24.615 1.00 23.18 ? 111 VAL   A HB   1 
ATOM   1512 H  HG11 . VAL   A 1 131 ? 20.615  4.733  25.065 1.00 29.55 ? 111 VAL   A HG11 1 
ATOM   1513 H  HG12 . VAL   A 1 131 ? 20.607  6.176  25.728 1.00 29.55 ? 111 VAL   A HG12 1 
ATOM   1514 H  HG13 . VAL   A 1 131 ? 20.320  4.891  26.618 1.00 29.55 ? 111 VAL   A HG13 1 
ATOM   1515 H  HG21 . VAL   A 1 131 ? 18.713  3.447  24.845 1.00 24.56 ? 111 VAL   A HG21 1 
ATOM   1516 H  HG22 . VAL   A 1 131 ? 17.841  3.695  26.150 1.00 24.56 ? 111 VAL   A HG22 1 
ATOM   1517 H  HG23 . VAL   A 1 131 ? 17.283  4.132  24.732 1.00 24.56 ? 111 VAL   A HG23 1 
ATOM   1518 N  N    . PHE   A 1 132 ? 18.242  8.337  27.710 1.00 16.33 ? 112 PHE   A N    1 
ATOM   1519 C  CA   . PHE   A 1 132 ? 18.555  9.754  27.845 1.00 15.96 ? 112 PHE   A CA   1 
ATOM   1520 C  C    . PHE   A 1 132 ? 19.967  9.935  28.381 1.00 20.29 ? 112 PHE   A C    1 
ATOM   1521 O  O    . PHE   A 1 132 ? 20.420  9.149  29.220 1.00 20.44 ? 112 PHE   A O    1 
ATOM   1522 C  CB   . PHE   A 1 132 ? 17.573  10.432 28.786 1.00 20.10 ? 112 PHE   A CB   1 
ATOM   1523 C  CG   . PHE   A 1 132 ? 16.436  11.109 28.084 1.00 14.78 ? 112 PHE   A CG   1 
ATOM   1524 C  CD1  . PHE   A 1 132 ? 15.852  10.521 26.976 1.00 20.73 ? 112 PHE   A CD1  1 
ATOM   1525 C  CD2  . PHE   A 1 132 ? 15.951  12.325 28.525 1.00 23.45 ? 112 PHE   A CD2  1 
ATOM   1526 C  CE1  . PHE   A 1 132 ? 14.797  11.128 26.323 1.00 19.96 ? 112 PHE   A CE1  1 
ATOM   1527 C  CE2  . PHE   A 1 132 ? 14.902  12.944 27.874 1.00 22.66 ? 112 PHE   A CE2  1 
ATOM   1528 C  CZ   . PHE   A 1 132 ? 14.322  12.345 26.772 1.00 19.70 ? 112 PHE   A CZ   1 
ATOM   1529 H  H    . PHE   A 1 132 ? 17.891  7.993  28.416 1.00 19.62 ? 112 PHE   A H    1 
ATOM   1530 H  HA   . PHE   A 1 132 ? 18.480  10.161 26.972 1.00 19.17 ? 112 PHE   A HA   1 
ATOM   1531 H  HB2  . PHE   A 1 132 ? 17.199  9.765  29.383 1.00 24.13 ? 112 PHE   A HB2  1 
ATOM   1532 H  HB3  . PHE   A 1 132 ? 18.046  11.104 29.300 1.00 24.13 ? 112 PHE   A HB3  1 
ATOM   1533 H  HD1  . PHE   A 1 132 ? 16.168  9.701  26.673 1.00 24.89 ? 112 PHE   A HD1  1 
ATOM   1534 H  HD2  . PHE   A 1 132 ? 16.336  12.732 29.267 1.00 28.16 ? 112 PHE   A HD2  1 
ATOM   1535 H  HE1  . PHE   A 1 132 ? 14.413  10.723 25.579 1.00 23.97 ? 112 PHE   A HE1  1 
ATOM   1536 H  HE2  . PHE   A 1 132 ? 14.583  13.762 28.180 1.00 27.21 ? 112 PHE   A HE2  1 
ATOM   1537 H  HZ   . PHE   A 1 132 ? 13.615  12.761 26.333 1.00 23.65 ? 112 PHE   A HZ   1 
ATOM   1538 N  N    . PRO   A 1 133 ? 20.667  10.965 27.909 1.00 23.00 ? 113 PRO   A N    1 
ATOM   1539 C  CA   . PRO   A 1 133 ? 22.048  11.192 28.369 1.00 23.82 ? 113 PRO   A CA   1 
ATOM   1540 C  C    . PRO   A 1 133 ? 22.113  11.352 29.879 1.00 19.63 ? 113 PRO   A C    1 
ATOM   1541 O  O    . PRO   A 1 133 ? 21.464  12.223 30.457 1.00 24.29 ? 113 PRO   A O    1 
ATOM   1542 C  CB   . PRO   A 1 133 ? 22.452  12.485 27.646 1.00 23.38 ? 113 PRO   A CB   1 
ATOM   1543 C  CG   . PRO   A 1 133 ? 21.540  12.570 26.457 1.00 26.89 ? 113 PRO   A CG   1 
ATOM   1544 C  CD   . PRO   A 1 133 ? 20.239  11.958 26.904 1.00 24.16 ? 113 PRO   A CD   1 
ATOM   1545 H  HA   . PRO   A 1 133 ? 22.627  10.466 28.090 1.00 28.60 ? 113 PRO   A HA   1 
ATOM   1546 H  HB2  . PRO   A 1 133 ? 22.315  13.243 28.236 1.00 28.07 ? 113 PRO   A HB2  1 
ATOM   1547 H  HB3  . PRO   A 1 133 ? 23.379  12.431 27.370 1.00 28.07 ? 113 PRO   A HB3  1 
ATOM   1548 H  HG2  . PRO   A 1 133 ? 21.413  13.499 26.209 1.00 32.29 ? 113 PRO   A HG2  1 
ATOM   1549 H  HG3  . PRO   A 1 133 ? 21.919  12.067 25.719 1.00 32.29 ? 113 PRO   A HG3  1 
ATOM   1550 H  HD2  . PRO   A 1 133 ? 19.668  12.629 27.309 1.00 29.01 ? 113 PRO   A HD2  1 
ATOM   1551 H  HD3  . PRO   A 1 133 ? 19.809  11.529 26.149 1.00 29.01 ? 113 PRO   A HD3  1 
ATOM   1552 N  N    . GLY   A 1 134 ? 22.919  10.514 30.517 1.00 25.54 ? 114 GLY   A N    1 
ATOM   1553 C  CA   . GLY   A 1 134 ? 23.154  10.668 31.936 1.00 26.34 ? 114 GLY   A CA   1 
ATOM   1554 C  C    . GLY   A 1 134 ? 22.081  10.101 32.831 1.00 31.30 ? 114 GLY   A C    1 
ATOM   1555 O  O    . GLY   A 1 134 ? 22.082  10.390 34.035 1.00 28.23 ? 114 GLY   A O    1 
ATOM   1556 H  H    . GLY   A 1 134 ? 23.336  9.856  30.152 1.00 30.66 ? 114 GLY   A H    1 
ATOM   1557 H  HA2  . GLY   A 1 134 ? 23.991  10.234 32.164 1.00 31.62 ? 114 GLY   A HA2  1 
ATOM   1558 H  HA3  . GLY   A 1 134 ? 23.242  11.612 32.139 1.00 31.62 ? 114 GLY   A HA3  1 
ATOM   1559 N  N    . TYR   A 1 135 ? 21.163  9.313  32.285 1.00 21.73 ? 115 TYR   A N    1 
ATOM   1560 C  CA   . TYR   A 1 135 ? 20.173  8.587  33.062 1.00 20.30 ? 115 TYR   A CA   1 
ATOM   1561 C  C    . TYR   A 1 135 ? 20.285  7.097  32.754 1.00 20.83 ? 115 TYR   A C    1 
ATOM   1562 O  O    . TYR   A 1 135 ? 20.729  6.716  31.664 1.00 23.71 ? 115 TYR   A O    1 
ATOM   1563 C  CB   . TYR   A 1 135 ? 18.743  9.055  32.757 1.00 20.09 ? 115 TYR   A CB   1 
ATOM   1564 C  CG   . TYR   A 1 135 ? 18.421  10.441 33.258 1.00 20.03 ? 115 TYR   A CG   1 
ATOM   1565 C  CD1  . TYR   A 1 135 ? 17.915  10.637 34.536 1.00 20.13 ? 115 TYR   A CD1  1 
ATOM   1566 C  CD2  . TYR   A 1 135 ? 18.617  11.553 32.452 1.00 16.96 ? 115 TYR   A CD2  1 
ATOM   1567 C  CE1  . TYR   A 1 135 ? 17.623  11.901 34.998 1.00 18.75 ? 115 TYR   A CE1  1 
ATOM   1568 C  CE2  . TYR   A 1 135 ? 18.326  12.820 32.903 1.00 16.29 ? 115 TYR   A CE2  1 
ATOM   1569 C  CZ   . TYR   A 1 135 ? 17.829  12.990 34.177 1.00 19.52 ? 115 TYR   A CZ   1 
ATOM   1570 O  OH   . TYR   A 1 135 ? 17.547  14.252 34.633 1.00 20.84 ? 115 TYR   A OH   1 
ATOM   1571 H  H    . TYR   A 1 135 ? 21.093  9.180  31.438 1.00 26.09 ? 115 TYR   A H    1 
ATOM   1572 H  HA   . TYR   A 1 135 ? 20.347  8.731  34.004 1.00 24.37 ? 115 TYR   A HA   1 
ATOM   1573 H  HB2  . TYR   A 1 135 ? 18.614  9.052  31.796 1.00 24.12 ? 115 TYR   A HB2  1 
ATOM   1574 H  HB3  . TYR   A 1 135 ? 18.119  8.439  33.173 1.00 24.12 ? 115 TYR   A HB3  1 
ATOM   1575 H  HD1  . TYR   A 1 135 ? 17.777  9.904  35.091 1.00 24.18 ? 115 TYR   A HD1  1 
ATOM   1576 H  HD2  . TYR   A 1 135 ? 18.954  11.440 31.593 1.00 20.37 ? 115 TYR   A HD2  1 
ATOM   1577 H  HE1  . TYR   A 1 135 ? 17.288  12.019 35.858 1.00 22.51 ? 115 TYR   A HE1  1 
ATOM   1578 H  HE2  . TYR   A 1 135 ? 18.467  13.557 32.353 1.00 19.56 ? 115 TYR   A HE2  1 
ATOM   1579 H  HH   . TYR   A 1 135 ? 17.259  14.215 35.421 1.00 25.02 ? 115 TYR   A HH   1 
ATOM   1580 N  N    . PRO   A 1 136 ? 19.888  6.233  33.685 1.00 21.71 ? 116 PRO   A N    1 
ATOM   1581 C  CA   . PRO   A 1 136 ? 19.878  4.795  33.385 1.00 21.94 ? 116 PRO   A CA   1 
ATOM   1582 C  C    . PRO   A 1 136 ? 18.924  4.501  32.239 1.00 27.52 ? 116 PRO   A C    1 
ATOM   1583 O  O    . PRO   A 1 136 ? 17.880  5.142  32.105 1.00 23.18 ? 116 PRO   A O    1 
ATOM   1584 C  CB   . PRO   A 1 136 ? 19.401  4.153  34.694 1.00 27.71 ? 116 PRO   A CB   1 
ATOM   1585 C  CG   . PRO   A 1 136 ? 19.555  5.213  35.742 1.00 29.43 ? 116 PRO   A CG   1 
ATOM   1586 C  CD   . PRO   A 1 136 ? 19.367  6.525  35.032 1.00 23.34 ? 116 PRO   A CD   1 
ATOM   1587 H  HA   . PRO   A 1 136 ? 20.769  4.480  33.166 1.00 26.34 ? 116 PRO   A HA   1 
ATOM   1588 H  HB2  . PRO   A 1 136 ? 18.471  3.890  34.608 1.00 33.27 ? 116 PRO   A HB2  1 
ATOM   1589 H  HB3  . PRO   A 1 136 ? 19.956  3.385  34.901 1.00 33.27 ? 116 PRO   A HB3  1 
ATOM   1590 H  HG2  . PRO   A 1 136 ? 18.877  5.095  36.425 1.00 35.33 ? 116 PRO   A HG2  1 
ATOM   1591 H  HG3  . PRO   A 1 136 ? 20.443  5.160  36.130 1.00 35.33 ? 116 PRO   A HG3  1 
ATOM   1592 H  HD2  . PRO   A 1 136 ? 18.427  6.759  34.991 1.00 28.03 ? 116 PRO   A HD2  1 
ATOM   1593 H  HD3  . PRO   A 1 136 ? 19.892  7.216  35.465 1.00 28.03 ? 116 PRO   A HD3  1 
ATOM   1594 N  N    . ARG   A 1 137 ? 19.288  3.530  31.406 1.00 24.00 ? 117 ARG   A N    1 
ATOM   1595 C  CA   . ARG   A 1 137 ? 18.362  3.069  30.384 1.00 18.98 ? 117 ARG   A CA   1 
ATOM   1596 C  C    . ARG   A 1 137 ? 17.068  2.616  31.049 1.00 26.24 ? 117 ARG   A C    1 
ATOM   1597 O  O    . ARG   A 1 137 ? 17.084  1.988  32.111 1.00 26.69 ? 117 ARG   A O    1 
ATOM   1598 C  CB   . ARG   A 1 137 ? 18.958  1.919  29.577 1.00 25.71 ? 117 ARG   A CB   1 
ATOM   1599 C  CG   . ARG   A 1 137 ? 18.267  1.729  28.230 0.48 29.07 ? 117 ARG   A CG   1 
ATOM   1600 C  CD   . ARG   A 1 137 ? 18.310  0.283  27.756 0.58 38.05 ? 117 ARG   A CD   1 
ATOM   1601 N  NE   . ARG   A 1 137 ? 17.712  0.141  26.433 0.45 36.23 ? 117 ARG   A NE   1 
ATOM   1602 C  CZ   . ARG   A 1 137 ? 18.332  0.436  25.298 0.88 34.86 ? 117 ARG   A CZ   1 
ATOM   1603 N  NH1  . ARG   A 1 137 ? 19.576  0.887  25.288 1.00 50.34 ? 117 ARG   A NH1  1 
ATOM   1604 N  NH2  . ARG   A 1 137 ? 17.685  0.285  24.146 0.32 30.56 ? 117 ARG   A NH2  1 
ATOM   1605 H  H    . ARG   A 1 137 ? 20.050  3.131  31.412 1.00 28.82 ? 117 ARG   A H    1 
ATOM   1606 H  HA   . ARG   A 1 137 ? 18.159  3.798  29.778 1.00 22.80 ? 117 ARG   A HA   1 
ATOM   1607 H  HB2  . ARG   A 1 137 ? 19.896  2.102  29.410 1.00 30.87 ? 117 ARG   A HB2  1 
ATOM   1608 H  HB3  . ARG   A 1 137 ? 18.864  1.096  30.082 1.00 30.87 ? 117 ARG   A HB3  1 
ATOM   1609 H  HG2  . ARG   A 1 137 ? 17.338  1.996  28.306 0.47 34.90 ? 117 ARG   A HG2  1 
ATOM   1610 H  HG3  . ARG   A 1 137 ? 18.719  2.273  27.567 0.47 34.90 ? 117 ARG   A HG3  1 
ATOM   1611 H  HD2  . ARG   A 1 137 ? 19.232  -0.014 27.710 0.57 45.67 ? 117 ARG   A HD2  1 
ATOM   1612 H  HD3  . ARG   A 1 137 ? 17.810  -0.271 28.376 0.55 45.67 ? 117 ARG   A HD3  1 
ATOM   1613 H  HE   . ARG   A 1 137 ? 16.905  -0.153 26.386 0.44 43.50 ? 117 ARG   A HE   1 
ATOM   1614 H  HH11 . ARG   A 1 137 ? 20.005  0.991  26.026 1.00 60.43 ? 117 ARG   A HH11 1 
ATOM   1615 H  HH12 . ARG   A 1 137 ? 19.958  1.073  24.540 1.00 60.43 ? 117 ARG   A HH12 1 
ATOM   1616 H  HH21 . ARG   A 1 137 ? 16.876  -0.007 24.142 0.34 36.69 ? 117 ARG   A HH21 1 
ATOM   1617 H  HH22 . ARG   A 1 137 ? 18.078  0.474  23.404 0.34 36.69 ? 117 ARG   A HH22 1 
ATOM   1618 N  N    . GLY   A 1 138 ? 15.937  2.940  30.424 1.00 23.01 ? 118 GLY   A N    1 
ATOM   1619 C  CA   . GLY   A 1 138 ? 14.647  2.639  31.006 1.00 23.64 ? 118 GLY   A CA   1 
ATOM   1620 C  C    . GLY   A 1 138 ? 13.652  2.197  29.955 1.00 16.91 ? 118 GLY   A C    1 
ATOM   1621 O  O    . GLY   A 1 138 ? 13.976  2.081  28.772 1.00 20.16 ? 118 GLY   A O    1 
ATOM   1622 H  H    . GLY   A 1 138 ? 15.897  3.335  29.661 1.00 27.63 ? 118 GLY   A H    1 
ATOM   1623 H  HA2  . GLY   A 1 138 ? 14.738  1.929  31.661 1.00 28.38 ? 118 GLY   A HA2  1 
ATOM   1624 H  HA3  . GLY   A 1 138 ? 14.298  3.428  31.450 1.00 28.38 ? 118 GLY   A HA3  1 
ATOM   1625 N  N    . GLN   A 1 139 ? 12.435  1.935  30.420 1.00 20.32 ? 119 GLN   A N    1 
ATOM   1626 C  CA   . GLN   A 1 139 ? 11.290  1.655  29.563 1.00 19.94 ? 119 GLN   A CA   1 
ATOM   1627 C  C    . GLN   A 1 139 ? 10.260  2.740  29.840 1.00 19.45 ? 119 GLN   A C    1 
ATOM   1628 O  O    . GLN   A 1 139 ? 9.874   2.953  30.991 1.00 22.78 ? 119 GLN   A O    1 
ATOM   1629 C  CB   . GLN   A 1 139 ? 10.721  0.264  29.831 1.00 24.91 ? 119 GLN   A CB   1 
ATOM   1630 C  CG   . GLN   A 1 139 ? 11.670  -0.870 29.461 1.00 38.72 ? 119 GLN   A CG   1 
ATOM   1631 C  CD   . GLN   A 1 139 ? 11.799  -1.069 27.959 1.00 50.40 ? 119 GLN   A CD   1 
ATOM   1632 O  OE1  . GLN   A 1 139 ? 10.877  -0.771 27.197 1.00 42.19 ? 119 GLN   A OE1  1 
ATOM   1633 N  NE2  . GLN   A 1 139 ? 12.948  -1.578 27.527 1.00 52.84 ? 119 GLN   A NE2  1 
ATOM   1634 H  H    . GLN   A 1 139 ? 12.243  1.913  31.258 1.00 24.41 ? 119 GLN   A H    1 
ATOM   1635 H  HA   . GLN   A 1 139 ? 11.555  1.708  28.632 1.00 23.94 ? 119 GLN   A HA   1 
ATOM   1636 H  HB2  . GLN   A 1 139 ? 10.520  0.186  30.777 1.00 29.91 ? 119 GLN   A HB2  1 
ATOM   1637 H  HB3  . GLN   A 1 139 ? 9.909   0.153  29.312 1.00 29.91 ? 119 GLN   A HB3  1 
ATOM   1638 H  HG2  . GLN   A 1 139 ? 12.552  -0.671 29.813 1.00 46.48 ? 119 GLN   A HG2  1 
ATOM   1639 H  HG3  . GLN   A 1 139 ? 11.338  -1.697 29.845 1.00 46.48 ? 119 GLN   A HG3  1 
ATOM   1640 H  HE21 . GLN   A 1 139 ? 13.569  -1.774 28.088 1.00 63.42 ? 119 GLN   A HE21 1 
ATOM   1641 H  HE22 . GLN   A 1 139 ? 13.071  -1.710 26.686 1.00 63.42 ? 119 GLN   A HE22 1 
ATOM   1642 N  N    . TYR   A 1 140 ? 9.845   3.442  28.797 1.00 17.72 ? 120 TYR   A N    1 
ATOM   1643 C  CA   . TYR   A 1 140 ? 8.937   4.576  28.906 1.00 16.24 ? 120 TYR   A CA   1 
ATOM   1644 C  C    . TYR   A 1 140 ? 7.636   4.221  28.208 1.00 18.15 ? 120 TYR   A C    1 
ATOM   1645 O  O    . TYR   A 1 140 ? 7.649   3.785  27.055 1.00 15.70 ? 120 TYR   A O    1 
ATOM   1646 C  CB   . TYR   A 1 140 ? 9.593   5.817  28.289 1.00 17.64 ? 120 TYR   A CB   1 
ATOM   1647 C  CG   . TYR   A 1 140 ? 8.736   7.059  28.195 1.00 15.90 ? 120 TYR   A CG   1 
ATOM   1648 C  CD1  . TYR   A 1 140 ? 7.855   7.407  29.207 1.00 15.56 ? 120 TYR   A CD1  1 
ATOM   1649 C  CD2  . TYR   A 1 140 ? 8.848   7.913  27.102 1.00 14.82 ? 120 TYR   A CD2  1 
ATOM   1650 C  CE1  . TYR   A 1 140 ? 7.074   8.556  29.111 1.00 17.67 ? 120 TYR   A CE1  1 
ATOM   1651 C  CE2  . TYR   A 1 140 ? 8.080   9.066  27.004 1.00 14.90 ? 120 TYR   A CE2  1 
ATOM   1652 C  CZ   . TYR   A 1 140 ? 7.194   9.378  28.009 1.00 15.27 ? 120 TYR   A CZ   1 
ATOM   1653 O  OH   . TYR   A 1 140 ? 6.428   10.520 27.903 1.00 16.43 ? 120 TYR   A OH   1 
ATOM   1654 H  H    . TYR   A 1 140 ? 10.083  3.276  27.988 1.00 21.28 ? 120 TYR   A H    1 
ATOM   1655 H  HA   . TYR   A 1 140 ? 8.748   4.758  29.840 1.00 19.50 ? 120 TYR   A HA   1 
ATOM   1656 H  HB2  . TYR   A 1 140 ? 10.371  6.045  28.822 1.00 21.19 ? 120 TYR   A HB2  1 
ATOM   1657 H  HB3  . TYR   A 1 140 ? 9.875   5.594  27.388 1.00 21.19 ? 120 TYR   A HB3  1 
ATOM   1658 H  HD1  . TYR   A 1 140 ? 7.765   6.852  29.948 1.00 18.69 ? 120 TYR   A HD1  1 
ATOM   1659 H  HD2  . TYR   A 1 140 ? 9.441   7.701  26.417 1.00 17.81 ? 120 TYR   A HD2  1 
ATOM   1660 H  HE1  . TYR   A 1 140 ? 6.478   8.772  29.791 1.00 21.23 ? 120 TYR   A HE1  1 
ATOM   1661 H  HE2  . TYR   A 1 140 ? 8.157   9.618  26.260 1.00 17.90 ? 120 TYR   A HE2  1 
ATOM   1662 H  HH   . TYR   A 1 140 ? 6.605   10.919 27.186 1.00 19.73 ? 120 TYR   A HH   1 
ATOM   1663 N  N    . ARG   A 1 141 ? 6.523   4.362  28.924 1.00 16.50 ? 121 ARG   A N    1 
ATOM   1664 C  CA   . ARG   A 1 141 ? 5.192   4.172  28.364 1.00 15.22 ? 121 ARG   A CA   1 
ATOM   1665 C  C    . ARG   A 1 141 ? 4.359   5.377  28.770 1.00 13.04 ? 121 ARG   A C    1 
ATOM   1666 O  O    . ARG   A 1 141 ? 4.439   5.819  29.918 1.00 15.37 ? 121 ARG   A O    1 
ATOM   1667 C  CB   . ARG   A 1 141 ? 4.513   2.899  28.877 1.00 22.36 ? 121 ARG   A CB   1 
ATOM   1668 C  CG   . ARG   A 1 141 ? 5.260   1.610  28.614 1.00 25.46 ? 121 ARG   A CG   1 
ATOM   1669 C  CD   . ARG   A 1 141 ? 4.613   0.439  29.350 1.00 37.00 ? 121 ARG   A CD   1 
ATOM   1670 N  NE   . ARG   A 1 141 ? 4.984   0.417  30.760 1.00 48.74 ? 121 ARG   A NE   1 
ATOM   1671 C  CZ   . ARG   A 1 141 ? 6.091   -0.141 31.232 1.00 59.44 ? 121 ARG   A CZ   1 
ATOM   1672 N  NH1  . ARG   A 1 141 ? 6.953   -0.751 30.435 1.00 56.38 ? 121 ARG   A NH1  1 
ATOM   1673 N  NH2  . ARG   A 1 141 ? 6.343   -0.081 32.537 1.00 62.06 ? 121 ARG   A NH2  1 
ATOM   1674 H  H    . ARG   A 1 141 ? 6.516   4.573  29.758 1.00 19.82 ? 121 ARG   A H    1 
ATOM   1675 H  HA   . ARG   A 1 141 ? 5.241   4.135  27.396 1.00 18.28 ? 121 ARG   A HA   1 
ATOM   1676 H  HB2  . ARG   A 1 141 ? 4.399   2.978  29.837 1.00 26.85 ? 121 ARG   A HB2  1 
ATOM   1677 H  HB3  . ARG   A 1 141 ? 3.644   2.823  28.453 1.00 26.85 ? 121 ARG   A HB3  1 
ATOM   1678 H  HG2  . ARG   A 1 141 ? 5.245   1.418  27.663 1.00 30.57 ? 121 ARG   A HG2  1 
ATOM   1679 H  HG3  . ARG   A 1 141 ? 6.174   1.699  28.926 1.00 30.57 ? 121 ARG   A HG3  1 
ATOM   1680 H  HD2  . ARG   A 1 141 ? 3.648   0.525  29.295 1.00 44.41 ? 121 ARG   A HD2  1 
ATOM   1681 H  HD3  . ARG   A 1 141 ? 4.896   -0.394 28.942 1.00 44.41 ? 121 ARG   A HD3  1 
ATOM   1682 H  HE   . ARG   A 1 141 ? 4.451   0.790  31.322 1.00 58.51 ? 121 ARG   A HE   1 
ATOM   1683 H  HH11 . ARG   A 1 141 ? 6.806   -0.796 29.590 1.00 67.67 ? 121 ARG   A HH11 1 
ATOM   1684 H  HH12 . ARG   A 1 141 ? 7.664   -1.105 30.765 1.00 67.67 ? 121 ARG   A HH12 1 
ATOM   1685 H  HH21 . ARG   A 1 141 ? 5.789   0.313  33.064 1.00 74.48 ? 121 ARG   A HH21 1 
ATOM   1686 H  HH22 . ARG   A 1 141 ? 7.057   -0.440 32.854 1.00 74.48 ? 121 ARG   A HH22 1 
ATOM   1687 N  N    . ASN   A 1 142 ? 3.564   5.914  27.848 1.00 13.21 ? 122 ASN   A N    1 
ATOM   1688 C  CA   . ASN   A 1 142 ? 2.719   7.041  28.222 1.00 14.02 ? 122 ASN   A CA   1 
ATOM   1689 C  C    . ASN   A 1 142 ? 1.514   7.118  27.301 1.00 15.03 ? 122 ASN   A C    1 
ATOM   1690 O  O    . ASN   A 1 142 ? 1.461   6.479  26.249 1.00 12.89 ? 122 ASN   A O    1 
ATOM   1691 C  CB   . ASN   A 1 142 ? 3.502   8.362  28.183 1.00 15.02 ? 122 ASN   A CB   1 
ATOM   1692 C  CG   . ASN   A 1 142 ? 3.084   9.346  29.277 1.00 14.50 ? 122 ASN   A CG   1 
ATOM   1693 O  OD1  . ASN   A 1 142 ? 2.043   9.193  29.927 1.00 14.47 ? 122 ASN   A OD1  1 
ATOM   1694 N  ND2  . ASN   A 1 142 ? 3.905   10.370 29.474 1.00 13.71 ? 122 ASN   A ND2  1 
ATOM   1695 H  H    . ASN   A 1 142 ? 3.496   5.656  27.030 1.00 15.87 ? 122 ASN   A H    1 
ATOM   1696 H  HA   . ASN   A 1 142 ? 2.396   6.908  29.127 1.00 16.84 ? 122 ASN   A HA   1 
ATOM   1697 H  HB2  . ASN   A 1 142 ? 4.447   8.173  28.292 1.00 18.05 ? 122 ASN   A HB2  1 
ATOM   1698 H  HB3  . ASN   A 1 142 ? 3.347   8.794  27.333 1.00 18.05 ? 122 ASN   A HB3  1 
ATOM   1699 H  HD21 . ASN   A 1 142 ? 3.723   10.957 30.075 1.00 16.48 ? 122 ASN   A HD21 1 
ATOM   1700 H  HD22 . ASN   A 1 142 ? 4.620   10.445 29.002 1.00 16.48 ? 122 ASN   A HD22 1 
ATOM   1701 N  N    . HIS   A 1 143 ? 0.537   7.895  27.745 1.00 12.58 ? 123 HIS   A N    1 
ATOM   1702 C  CA   . HIS   A 1 143 ? -0.641  8.250  26.975 1.00 11.96 ? 123 HIS   A CA   1 
ATOM   1703 C  C    . HIS   A 1 143 ? -0.399  9.606  26.340 1.00 15.49 ? 123 HIS   A C    1 
ATOM   1704 O  O    . HIS   A 1 143 ? 0.167   10.504 26.970 1.00 16.86 ? 123 HIS   A O    1 
ATOM   1705 C  CB   . HIS   A 1 143 ? -1.858  8.277  27.891 1.00 13.46 ? 123 HIS   A CB   1 
ATOM   1706 C  CG   . HIS   A 1 143 ? -3.112  8.725  27.223 1.00 14.69 ? 123 HIS   A CG   1 
ATOM   1707 N  ND1  . HIS   A 1 143 ? -3.496  10.047 27.180 1.00 18.13 ? 123 HIS   A ND1  1 
ATOM   1708 C  CD2  . HIS   A 1 143 ? -4.080  8.027  26.583 1.00 18.54 ? 123 HIS   A CD2  1 
ATOM   1709 C  CE1  . HIS   A 1 143 ? -4.640  10.146 26.527 1.00 18.88 ? 123 HIS   A CE1  1 
ATOM   1710 N  NE2  . HIS   A 1 143 ? -5.020  8.934  26.165 1.00 18.46 ? 123 HIS   A NE2  1 
ATOM   1711 H  H    . HIS   A 1 143 ? 0.537   8.245  28.531 1.00 15.12 ? 123 HIS   A H    1 
ATOM   1712 H  HA   . HIS   A 1 143 ? -0.789  7.596  26.274 1.00 14.37 ? 123 HIS   A HA   1 
ATOM   1713 H  HB2  . HIS   A 1 143 ? -2.009  7.383  28.234 1.00 16.18 ? 123 HIS   A HB2  1 
ATOM   1714 H  HB3  . HIS   A 1 143 ? -1.681  8.885  28.626 1.00 16.18 ? 123 HIS   A HB3  1 
ATOM   1715 H  HD2  . HIS   A 1 143 ? -4.104  7.106  26.453 1.00 22.26 ? 123 HIS   A HD2  1 
ATOM   1716 H  HE1  . HIS   A 1 143 ? -5.107  10.934 26.364 1.00 22.67 ? 123 HIS   A HE1  1 
ATOM   1717 H  HE2  . HIS   A 1 143 ? -5.736  8.745  25.727 1.00 22.17 ? 123 HIS   A HE2  1 
ATOM   1718 N  N    . PHE   A 1 144 ? -0.803  9.741  25.082 1.00 12.76 ? 124 PHE   A N    1 
ATOM   1719 C  CA   . PHE   A 1 144 ? -0.517  10.946 24.334 1.00 10.53 ? 124 PHE   A CA   1 
ATOM   1720 C  C    . PHE   A 1 144 ? -1.740  11.471 23.606 1.00 14.41 ? 124 PHE   A C    1 
ATOM   1721 O  O    . PHE   A 1 144 ? -2.575  10.705 23.114 1.00 14.02 ? 124 PHE   A O    1 
ATOM   1722 C  CB   . PHE   A 1 144 ? 0.565   10.705 23.282 1.00 13.45 ? 124 PHE   A CB   1 
ATOM   1723 C  CG   . PHE   A 1 144 ? 1.913   10.400 23.843 1.00 13.32 ? 124 PHE   A CG   1 
ATOM   1724 C  CD1  . PHE   A 1 144 ? 2.250   9.119  24.242 1.00 14.28 ? 124 PHE   A CD1  1 
ATOM   1725 C  CD2  . PHE   A 1 144 ? 2.863   11.397 23.932 1.00 14.20 ? 124 PHE   A CD2  1 
ATOM   1726 C  CE1  . PHE   A 1 144 ? 3.510   8.849  24.733 1.00 17.31 ? 124 PHE   A CE1  1 
ATOM   1727 C  CE2  . PHE   A 1 144 ? 4.112   11.134 24.420 1.00 14.30 ? 124 PHE   A CE2  1 
ATOM   1728 C  CZ   . PHE   A 1 144 ? 4.439   9.858  24.831 1.00 13.10 ? 124 PHE   A CZ   1 
ATOM   1729 H  H    . PHE   A 1 144 ? -1.244  9.147  24.643 1.00 15.34 ? 124 PHE   A H    1 
ATOM   1730 H  HA   . PHE   A 1 144 ? -0.205  11.638 24.937 1.00 12.65 ? 124 PHE   A HA   1 
ATOM   1731 H  HB2  . PHE   A 1 144 ? 0.299   9.953  22.730 1.00 16.15 ? 124 PHE   A HB2  1 
ATOM   1732 H  HB3  . PHE   A 1 144 ? 0.647   11.501 22.733 1.00 16.15 ? 124 PHE   A HB3  1 
ATOM   1733 H  HD1  . PHE   A 1 144 ? 1.622   8.435  24.179 1.00 17.15 ? 124 PHE   A HD1  1 
ATOM   1734 H  HD2  . PHE   A 1 144 ? 2.649   12.260 23.659 1.00 17.05 ? 124 PHE   A HD2  1 
ATOM   1735 H  HE1  . PHE   A 1 144 ? 3.727   7.988  25.009 1.00 20.79 ? 124 PHE   A HE1  1 
ATOM   1736 H  HE2  . PHE   A 1 144 ? 4.739   11.818 24.484 1.00 17.18 ? 124 PHE   A HE2  1 
ATOM   1737 H  HZ   . PHE   A 1 144 ? 5.289   9.679  25.164 1.00 15.73 ? 124 PHE   A HZ   1 
ATOM   1738 N  N    . LEU   A 1 145 ? -1.810  12.793 23.509 1.00 11.68 ? 125 LEU   A N    1 
ATOM   1739 C  CA   . LEU   A 1 145 ? -2.660  13.478 22.546 1.00 10.61 ? 125 LEU   A CA   1 
ATOM   1740 C  C    . LEU   A 1 145 ? -1.770  14.240 21.573 1.00 11.26 ? 125 LEU   A C    1 
ATOM   1741 O  O    . LEU   A 1 145 ? -0.816  14.901 21.987 1.00 13.79 ? 125 LEU   A O    1 
ATOM   1742 C  CB   . LEU   A 1 145 ? -3.624  14.435 23.252 1.00 12.63 ? 125 LEU   A CB   1 
ATOM   1743 C  CG   . LEU   A 1 145 ? -4.475  13.743 24.316 1.00 18.51 ? 125 LEU   A CG   1 
ATOM   1744 C  CD1  . LEU   A 1 145 ? -5.296  14.733 25.119 0.66 14.90 ? 125 LEU   A CD1  1 
ATOM   1745 C  CD2  . LEU   A 1 145 ? -5.392  12.715 23.692 1.00 18.79 ? 125 LEU   A CD2  1 
ATOM   1746 H  H    . LEU   A 1 145 ? -1.360  13.331 24.007 1.00 14.03 ? 125 LEU   A H    1 
ATOM   1747 H  HA   . LEU   A 1 145 ? -3.177  12.828 22.047 1.00 12.75 ? 125 LEU   A HA   1 
ATOM   1748 H  HB2  . LEU   A 1 145 ? -3.112  15.135 23.687 1.00 15.17 ? 125 LEU   A HB2  1 
ATOM   1749 H  HB3  . LEU   A 1 145 ? -4.223  14.822 22.594 1.00 15.17 ? 125 LEU   A HB3  1 
ATOM   1750 H  HG   . LEU   A 1 145 ? -3.889  13.279 24.934 1.00 22.23 ? 125 LEU   A HG   1 
ATOM   1751 H  HD11 . LEU   A 1 145 ? -5.876  14.244 25.724 0.64 17.90 ? 125 LEU   A HD11 1 
ATOM   1752 H  HD12 . LEU   A 1 145 ? -4.696  15.302 25.625 0.63 17.90 ? 125 LEU   A HD12 1 
ATOM   1753 H  HD13 . LEU   A 1 145 ? -5.829  15.268 24.511 0.63 17.90 ? 125 LEU   A HD13 1 
ATOM   1754 H  HD21 . LEU   A 1 145 ? -5.999  12.381 24.370 1.00 22.57 ? 125 LEU   A HD21 1 
ATOM   1755 H  HD22 . LEU   A 1 145 ? -5.894  13.134 22.976 1.00 22.57 ? 125 LEU   A HD22 1 
ATOM   1756 H  HD23 . LEU   A 1 145 ? -4.858  11.986 23.339 1.00 22.57 ? 125 LEU   A HD23 1 
ATOM   1757 N  N    . HIS   A 1 146 ? -2.078  14.137 20.274 1.00 10.70 ? 126 HIS   A N    1 
ATOM   1758 C  CA   . HIS   A 1 146 ? -1.367  14.878 19.243 1.00 10.66 ? 126 HIS   A CA   1 
ATOM   1759 C  C    . HIS   A 1 146 ? -2.335  15.812 18.527 1.00 12.63 ? 126 HIS   A C    1 
ATOM   1760 O  O    . HIS   A 1 146 ? -3.473  15.433 18.230 1.00 14.38 ? 126 HIS   A O    1 
ATOM   1761 C  CB   . HIS   A 1 146 ? -0.744  13.994 18.171 1.00 12.29 ? 126 HIS   A CB   1 
ATOM   1762 C  CG   . HIS   A 1 146 ? 0.396   13.147 18.631 1.00 16.10 ? 126 HIS   A CG   1 
ATOM   1763 N  ND1  . HIS   A 1 146 ? 1.709   13.451 18.340 1.00 17.77 ? 126 HIS   A ND1  1 
ATOM   1764 C  CD2  . HIS   A 1 146 ? 0.419   11.970 19.298 1.00 15.59 ? 126 HIS   A CD2  1 
ATOM   1765 C  CE1  . HIS   A 1 146 ? 2.493   12.513 18.840 1.00 17.62 ? 126 HIS   A CE1  1 
ATOM   1766 N  NE2  . HIS   A 1 146 ? 1.736   11.600 19.420 1.00 14.94 ? 126 HIS   A NE2  1 
ATOM   1767 H  H    . HIS   A 1 146 ? -2.705  13.635 19.967 1.00 12.86 ? 126 HIS   A H    1 
ATOM   1768 H  HA   . HIS   A 1 146 ? -0.666  15.410 19.648 1.00 12.81 ? 126 HIS   A HA   1 
ATOM   1769 H  HB2  . HIS   A 1 146 ? -1.427  13.402 17.824 1.00 14.77 ? 126 HIS   A HB2  1 
ATOM   1770 H  HB3  . HIS   A 1 146 ? -0.415  14.562 17.457 1.00 14.77 ? 126 HIS   A HB3  1 
ATOM   1771 H  HD2  . HIS   A 1 146 ? -0.318  11.504 19.621 1.00 18.72 ? 126 HIS   A HD2  1 
ATOM   1772 H  HE1  . HIS   A 1 146 ? 3.421   12.495 18.787 1.00 21.17 ? 126 HIS   A HE1  1 
ATOM   1773 H  HE2  . HIS   A 1 146 ? 2.022   10.895 19.820 1.00 17.95 ? 126 HIS   A HE2  1 
ATOM   1774 N  N    . SER   A 1 147 ? -1.856  17.011 18.220 1.00 9.90  ? 127 SER   A N    1 
ATOM   1775 C  CA   . SER   A 1 147 ? -2.551  17.999 17.407 1.00 9.15  ? 127 SER   A CA   1 
ATOM   1776 C  C    . SER   A 1 147 ? -1.795  18.141 16.093 1.00 11.56 ? 127 SER   A C    1 
ATOM   1777 O  O    . SER   A 1 147 ? -0.576  18.335 16.110 1.00 11.57 ? 127 SER   A O    1 
ATOM   1778 C  CB   . SER   A 1 147 ? -2.594  19.341 18.140 1.00 10.84 ? 127 SER   A CB   1 
ATOM   1779 O  OG   . SER   A 1 147 ? -3.171  20.360 17.354 1.00 12.45 ? 127 SER   A OG   1 
ATOM   1780 H  H    . SER   A 1 147 ? -1.087  17.288 18.488 1.00 11.90 ? 127 SER   A H    1 
ATOM   1781 H  HA   . SER   A 1 147 ? -3.457  17.706 17.224 1.00 11.00 ? 127 SER   A HA   1 
ATOM   1782 H  HB2  . SER   A 1 147 ? -3.111  19.239 18.950 1.00 13.03 ? 127 SER   A HB2  1 
ATOM   1783 H  HB3  . SER   A 1 147 ? -1.686  19.600 18.364 1.00 13.03 ? 127 SER   A HB3  1 
ATOM   1784 H  HG   . SER   A 1 147 ? -2.699  20.501 16.674 1.00 14.96 ? 127 SER   A HG   1 
ATOM   1785 N  N    . PHE   A 1 148 ? -2.504  18.052 14.966 1.00 12.26 ? 128 PHE   A N    1 
ATOM   1786 C  CA   . PHE   A 1 148 ? -1.909  18.239 13.644 1.00 11.48 ? 128 PHE   A CA   1 
ATOM   1787 C  C    . PHE   A 1 148 ? -2.665  19.336 12.903 1.00 11.69 ? 128 PHE   A C    1 
ATOM   1788 O  O    . PHE   A 1 148 ? -3.866  19.196 12.639 1.00 13.67 ? 128 PHE   A O    1 
ATOM   1789 C  CB   . PHE   A 1 148 ? -1.943  16.954 12.796 1.00 12.28 ? 128 PHE   A CB   1 
ATOM   1790 C  CG   . PHE   A 1 148 ? -1.084  15.839 13.313 1.00 10.45 ? 128 PHE   A CG   1 
ATOM   1791 C  CD1  . PHE   A 1 148 ? -1.589  14.915 14.208 1.00 12.55 ? 128 PHE   A CD1  1 
ATOM   1792 C  CD2  . PHE   A 1 148 ? 0.234   15.699 12.892 1.00 11.12 ? 128 PHE   A CD2  1 
ATOM   1793 C  CE1  . PHE   A 1 148 ? -0.805  13.884 14.680 1.00 12.36 ? 128 PHE   A CE1  1 
ATOM   1794 C  CE2  . PHE   A 1 148 ? 1.020   14.671 13.361 1.00 11.28 ? 128 PHE   A CE2  1 
ATOM   1795 C  CZ   . PHE   A 1 148 ? 0.507   13.757 14.250 1.00 11.66 ? 128 PHE   A CZ   1 
ATOM   1796 H  H    . PHE   A 1 148 ? -3.347  17.881 14.942 1.00 14.73 ? 128 PHE   A H    1 
ATOM   1797 H  HA   . PHE   A 1 148 ? -0.985  18.517 13.740 1.00 13.79 ? 128 PHE   A HA   1 
ATOM   1798 H  HB2  . PHE   A 1 148 ? -2.856  16.629 12.763 1.00 14.76 ? 128 PHE   A HB2  1 
ATOM   1799 H  HB3  . PHE   A 1 148 ? -1.640  17.167 11.900 1.00 14.76 ? 128 PHE   A HB3  1 
ATOM   1800 H  HD1  . PHE   A 1 148 ? -2.469  14.991 14.498 1.00 15.08 ? 128 PHE   A HD1  1 
ATOM   1801 H  HD2  . PHE   A 1 148 ? 0.590   16.310 12.288 1.00 13.36 ? 128 PHE   A HD2  1 
ATOM   1802 H  HE1  . PHE   A 1 148 ? -1.158  13.270 15.283 1.00 14.86 ? 128 PHE   A HE1  1 
ATOM   1803 H  HE2  . PHE   A 1 148 ? 1.900   14.591 13.071 1.00 13.56 ? 128 PHE   A HE2  1 
ATOM   1804 H  HZ   . PHE   A 1 148 ? 1.039   13.064 14.569 1.00 14.01 ? 128 PHE   A HZ   1 
ATOM   1805 N  N    . ARG   A 1 149 ? -1.967  20.405 12.539 1.00 13.50 ? 129 ARG   A N    1 
ATOM   1806 C  CA   . ARG   A 1 149 ? -2.528  21.444 11.688 1.00 12.40 ? 129 ARG   A CA   1 
ATOM   1807 C  C    . ARG   A 1 149 ? -1.785  21.477 10.363 1.00 13.96 ? 129 ARG   A C    1 
ATOM   1808 O  O    . ARG   A 1 149 ? -0.554  21.391 10.330 1.00 14.93 ? 129 ARG   A O    1 
ATOM   1809 C  CB   . ARG   A 1 149 ? -2.462  22.808 12.373 1.00 15.36 ? 129 ARG   A CB   1 
ATOM   1810 C  CG   . ARG   A 1 149 ? -3.273  22.833 13.654 1.00 14.85 ? 129 ARG   A CG   1 
ATOM   1811 C  CD   . ARG   A 1 149 ? -3.384  24.226 14.231 1.00 17.05 ? 129 ARG   A CD   1 
ATOM   1812 N  NE   . ARG   A 1 149 ? -4.246  25.064 13.405 1.00 21.60 ? 129 ARG   A NE   1 
ATOM   1813 C  CZ   . ARG   A 1 149 ? -4.524  26.333 13.665 1.00 25.98 ? 129 ARG   A CZ   1 
ATOM   1814 N  NH1  . ARG   A 1 149 ? -3.982  26.961 14.694 1.00 24.55 ? 129 ARG   A NH1  1 
ATOM   1815 N  NH2  . ARG   A 1 149 ? -5.370  26.988 12.873 1.00 23.97 ? 129 ARG   A NH2  1 
ATOM   1816 H  H    . ARG   A 1 149 ? -1.154  20.553 12.776 1.00 16.21 ? 129 ARG   A H    1 
ATOM   1817 H  HA   . ARG   A 1 149 ? -3.458  21.243 11.511 1.00 14.89 ? 129 ARG   A HA   1 
ATOM   1818 H  HB2  . ARG   A 1 149 ? -1.539  23.010 12.594 1.00 18.45 ? 129 ARG   A HB2  1 
ATOM   1819 H  HB3  . ARG   A 1 149 ? -2.819  23.483 11.775 1.00 18.45 ? 129 ARG   A HB3  1 
ATOM   1820 H  HG2  . ARG   A 1 149 ? -4.169  22.510 13.470 1.00 17.84 ? 129 ARG   A HG2  1 
ATOM   1821 H  HG3  . ARG   A 1 149 ? -2.843  22.266 14.314 1.00 17.84 ? 129 ARG   A HG3  1 
ATOM   1822 H  HD2  . ARG   A 1 149 ? -3.766  24.177 15.121 1.00 20.47 ? 129 ARG   A HD2  1 
ATOM   1823 H  HD3  . ARG   A 1 149 ? -2.504  24.632 14.264 1.00 20.47 ? 129 ARG   A HD3  1 
ATOM   1824 H  HE   . ARG   A 1 149 ? -4.597  24.711 12.703 1.00 25.94 ? 129 ARG   A HE   1 
ATOM   1825 H  HH11 . ARG   A 1 149 ? -3.436  26.548 15.214 1.00 29.48 ? 129 ARG   A HH11 1 
ATOM   1826 H  HH12 . ARG   A 1 149 ? -4.176  27.785 14.844 1.00 29.48 ? 129 ARG   A HH12 1 
ATOM   1827 H  HH21 . ARG   A 1 149 ? -5.726  26.588 12.200 1.00 28.78 ? 129 ARG   A HH21 1 
ATOM   1828 H  HH22 . ARG   A 1 149 ? -5.555  27.813 13.030 1.00 28.78 ? 129 ARG   A HH22 1 
ATOM   1829 N  N    . PHE   A 1 150 ? -2.549  21.616 9.279  1.00 16.10 ? 130 PHE   A N    1 
ATOM   1830 C  CA   . PHE   A 1 150 ? -2.054  21.427 7.928  1.00 14.85 ? 130 PHE   A CA   1 
ATOM   1831 C  C    . PHE   A 1 150 ? -2.103  22.713 7.120  1.00 17.34 ? 130 PHE   A C    1 
ATOM   1832 O  O    . PHE   A 1 150 ? -2.947  23.582 7.345  1.00 16.95 ? 130 PHE   A O    1 
ATOM   1833 C  CB   . PHE   A 1 150 ? -2.879  20.359 7.192  1.00 13.93 ? 130 PHE   A CB   1 
ATOM   1834 C  CG   . PHE   A 1 150 ? -2.555  18.965 7.605  1.00 16.68 ? 130 PHE   A CG   1 
ATOM   1835 C  CD1  . PHE   A 1 150 ? -3.146  18.402 8.726  1.00 17.88 ? 130 PHE   A CD1  1 
ATOM   1836 C  CD2  . PHE   A 1 150 ? -1.645  18.219 6.887  1.00 17.61 ? 130 PHE   A CD2  1 
ATOM   1837 C  CE1  . PHE   A 1 150 ? -2.832  17.117 9.112  1.00 17.81 ? 130 PHE   A CE1  1 
ATOM   1838 C  CE2  . PHE   A 1 150 ? -1.330  16.934 7.270  1.00 19.37 ? 130 PHE   A CE2  1 
ATOM   1839 C  CZ   . PHE   A 1 150 ? -1.919  16.384 8.384  1.00 16.31 ? 130 PHE   A CZ   1 
ATOM   1840 H  H    . PHE   A 1 150 ? -3.382  21.826 9.309  1.00 19.33 ? 130 PHE   A H    1 
ATOM   1841 H  HA   . PHE   A 1 150 ? -1.133  21.127 7.964  1.00 17.84 ? 130 PHE   A HA   1 
ATOM   1842 H  HB2  . PHE   A 1 150 ? -3.820  20.511 7.372  1.00 16.74 ? 130 PHE   A HB2  1 
ATOM   1843 H  HB3  . PHE   A 1 150 ? -2.710  20.434 6.240  1.00 16.74 ? 130 PHE   A HB3  1 
ATOM   1844 H  HD1  . PHE   A 1 150 ? -3.758  18.896 9.222  1.00 21.48 ? 130 PHE   A HD1  1 
ATOM   1845 H  HD2  . PHE   A 1 150 ? -1.239  18.587 6.136  1.00 21.16 ? 130 PHE   A HD2  1 
ATOM   1846 H  HE1  . PHE   A 1 150 ? -3.234  16.745 9.864  1.00 21.39 ? 130 PHE   A HE1  1 
ATOM   1847 H  HE2  . PHE   A 1 150 ? -0.716  16.439 6.777  1.00 23.26 ? 130 PHE   A HE2  1 
ATOM   1848 H  HZ   . PHE   A 1 150 ? -1.710  15.515 8.640  1.00 19.59 ? 130 PHE   A HZ   1 
ATOM   1849 N  N    . GLU   A 1 151 ? -1.198  22.803 6.148  1.00 17.99 ? 131 GLU   A N    1 
ATOM   1850 C  CA   . GLU   A 1 151 ? -1.180  23.876 5.162  1.00 22.05 ? 131 GLU   A CA   1 
ATOM   1851 C  C    . GLU   A 1 151 ? -0.717  23.279 3.843  1.00 21.93 ? 131 GLU   A C    1 
ATOM   1852 O  O    . GLU   A 1 151 ? 0.363   22.685 3.779  1.00 20.50 ? 131 GLU   A O    1 
ATOM   1853 C  CB   . GLU   A 1 151 ? -0.262  25.012 5.618  1.00 22.28 ? 131 GLU   A CB   1 
ATOM   1854 C  CG   . GLU   A 1 151 ? 0.014   26.090 4.592  1.00 29.27 ? 131 GLU   A CG   1 
ATOM   1855 C  CD   . GLU   A 1 151 ? 1.051   27.079 5.094  1.00 37.03 ? 131 GLU   A CD   1 
ATOM   1856 O  OE1  . GLU   A 1 151 ? 0.730   27.854 6.020  1.00 39.20 ? 131 GLU   A OE1  1 
ATOM   1857 O  OE2  . GLU   A 1 151 ? 2.193   27.055 4.589  1.00 46.72 ? 131 GLU   A OE2  1 
ATOM   1858 H  H    . GLU   A 1 151 ? -0.564  22.233 6.038  1.00 21.60 ? 131 GLU   A H    1 
ATOM   1859 H  HA   . GLU   A 1 151 ? -2.076  24.228 5.046  1.00 26.48 ? 131 GLU   A HA   1 
ATOM   1860 H  HB2  . GLU   A 1 151 ? -0.667  25.442 6.388  1.00 26.76 ? 131 GLU   A HB2  1 
ATOM   1861 H  HB3  . GLU   A 1 151 ? 0.592   24.630 5.874  1.00 26.76 ? 131 GLU   A HB3  1 
ATOM   1862 H  HG2  . GLU   A 1 151 ? 0.355   25.687 3.779  1.00 35.14 ? 131 GLU   A HG2  1 
ATOM   1863 H  HG3  . GLU   A 1 151 ? -0.806  26.575 4.409  1.00 35.14 ? 131 GLU   A HG3  1 
ATOM   1864 N  N    . ASN   A 1 152 ? -1.543  23.401 2.805  0.91 21.11 ? 132 ASN   A N    1 
ATOM   1865 C  CA   . ASN   A 1 152 ? -1.163  22.962 1.458  0.91 21.64 ? 132 ASN   A CA   1 
ATOM   1866 C  C    . ASN   A 1 152 ? -0.663  21.519 1.461  0.91 18.51 ? 132 ASN   A C    1 
ATOM   1867 O  O    . ASN   A 1 152 ? 0.368   21.189 0.873  0.91 21.13 ? 132 ASN   A O    1 
ATOM   1868 C  CB   . ASN   A 1 152 ? -0.105  23.899 0.864  0.91 24.43 ? 132 ASN   A CB   1 
ATOM   1869 C  CG   . ASN   A 1 152 ? 0.128   23.663 -0.622 0.91 45.85 ? 132 ASN   A CG   1 
ATOM   1870 O  OD1  . ASN   A 1 152 ? -0.704  23.067 -1.306 0.91 46.94 ? 132 ASN   A OD1  1 
ATOM   1871 N  ND2  . ASN   A 1 152 ? 1.263   24.139 -1.127 0.91 33.64 ? 132 ASN   A ND2  1 
ATOM   1872 H  H    . ASN   A 1 152 ? -2.334  23.736 2.853  0.91 25.35 ? 132 ASN   A H    1 
ATOM   1873 H  HA   . ASN   A 1 152 ? -1.946  23.001 0.887  0.91 25.99 ? 132 ASN   A HA   1 
ATOM   1874 H  HB2  . ASN   A 1 152 ? -0.397  24.817 0.979  0.91 29.34 ? 132 ASN   A HB2  1 
ATOM   1875 H  HB3  . ASN   A 1 152 ? 0.736   23.759 1.326  0.91 29.34 ? 132 ASN   A HB3  1 
ATOM   1876 H  HD21 . ASN   A 1 152 ? 1.441   24.032 -1.962 0.91 40.38 ? 132 ASN   A HD21 1 
ATOM   1877 H  HD22 . ASN   A 1 152 ? 1.820   24.552 -0.618 0.91 40.38 ? 132 ASN   A HD22 1 
ATOM   1878 N  N    . GLY   A 1 153 ? -1.384  20.655 2.164  1.00 23.57 ? 133 GLY   A N    1 
ATOM   1879 C  CA   . GLY   A 1 153 ? -1.153  19.232 2.083  1.00 24.49 ? 133 GLY   A CA   1 
ATOM   1880 C  C    . GLY   A 1 153 ? -0.101  18.672 3.013  1.00 19.09 ? 133 GLY   A C    1 
ATOM   1881 O  O    . GLY   A 1 153 ? 0.119   17.452 3.005  1.00 16.59 ? 133 GLY   A O    1 
ATOM   1882 H  H    . GLY   A 1 153 ? -2.019  20.877 2.700  1.00 28.30 ? 133 GLY   A H    1 
ATOM   1883 H  HA2  . GLY   A 1 153 ? -1.986  18.772 2.270  1.00 29.40 ? 133 GLY   A HA2  1 
ATOM   1884 H  HA3  . GLY   A 1 153 ? -0.891  19.012 1.176  1.00 29.40 ? 133 GLY   A HA3  1 
ATOM   1885 N  N    . LEU   A 1 154 ? 0.554   19.504 3.816  1.00 18.15 ? 134 LEU   A N    1 
ATOM   1886 C  CA   . LEU   A 1 154 ? 1.574   19.015 4.725  1.00 11.77 ? 134 LEU   A CA   1 
ATOM   1887 C  C    . LEU   A 1 154 ? 1.383   19.616 6.108  1.00 13.36 ? 134 LEU   A C    1 
ATOM   1888 O  O    . LEU   A 1 154 ? 0.605   20.553 6.314  1.00 17.16 ? 134 LEU   A O    1 
ATOM   1889 C  CB   . LEU   A 1 154 ? 2.984   19.320 4.199  1.00 14.04 ? 134 LEU   A CB   1 
ATOM   1890 C  CG   . LEU   A 1 154 ? 3.386   18.605 2.910  1.00 16.26 ? 134 LEU   A CG   1 
ATOM   1891 C  CD1  . LEU   A 1 154 ? 4.720   19.150 2.416  1.00 14.57 ? 134 LEU   A CD1  1 
ATOM   1892 C  CD2  . LEU   A 1 154 ? 3.471   17.107 3.116  1.00 17.95 ? 134 LEU   A CD2  1 
ATOM   1893 H  H    . LEU   A 1 154 ? 0.425   20.353 3.852  1.00 21.80 ? 134 LEU   A H    1 
ATOM   1894 H  HA   . LEU   A 1 154 ? 1.490   18.053 4.812  1.00 14.14 ? 134 LEU   A HA   1 
ATOM   1895 H  HB2  . LEU   A 1 154 ? 3.048   20.274 4.033  1.00 16.87 ? 134 LEU   A HB2  1 
ATOM   1896 H  HB3  . LEU   A 1 154 ? 3.626   19.068 4.881  1.00 16.87 ? 134 LEU   A HB3  1 
ATOM   1897 H  HG   . LEU   A 1 154 ? 2.718   18.779 2.228  1.00 19.53 ? 134 LEU   A HG   1 
ATOM   1898 H  HD11 . LEU   A 1 154 ? 4.966   18.689 1.599  1.00 17.50 ? 134 LEU   A HD11 1 
ATOM   1899 H  HD12 . LEU   A 1 154 ? 4.629   20.101 2.245  1.00 17.50 ? 134 LEU   A HD12 1 
ATOM   1900 H  HD13 . LEU   A 1 154 ? 5.394   18.999 3.097  1.00 17.50 ? 134 LEU   A HD13 1 
ATOM   1901 H  HD21 . LEU   A 1 154 ? 3.828   16.698 2.312  1.00 21.55 ? 134 LEU   A HD21 1 
ATOM   1902 H  HD22 . LEU   A 1 154 ? 4.056   16.925 3.868  1.00 21.55 ? 134 LEU   A HD22 1 
ATOM   1903 H  HD23 . LEU   A 1 154 ? 2.583   16.761 3.297  1.00 21.55 ? 134 LEU   A HD23 1 
ATOM   1904 N  N    . ILE   A 1 155 ? 2.114   19.062 7.066  1.00 12.70 ? 135 ILE   A N    1 
ATOM   1905 C  CA   . ILE   A 1 155 ? 1.956   19.467 8.454  1.00 13.93 ? 135 ILE   A CA   1 
ATOM   1906 C  C    . ILE   A 1 155 ? 2.642   20.808 8.678  1.00 13.71 ? 135 ILE   A C    1 
ATOM   1907 O  O    . ILE   A 1 155 ? 3.852   20.945 8.474  1.00 14.23 ? 135 ILE   A O    1 
ATOM   1908 C  CB   . ILE   A 1 155 ? 2.510   18.405 9.408  1.00 11.16 ? 135 ILE   A CB   1 
ATOM   1909 C  CG1  . ILE   A 1 155 ? 1.800   17.067 9.220  1.00 11.77 ? 135 ILE   A CG1  1 
ATOM   1910 C  CG2  . ILE   A 1 155 ? 2.375   18.915 10.847 1.00 16.92 ? 135 ILE   A CG2  1 
ATOM   1911 C  CD1  . ILE   A 1 155 ? 2.506   15.908 9.947  1.00 15.27 ? 135 ILE   A CD1  1 
ATOM   1912 H  H    . ILE   A 1 155 ? 2.706   18.452 6.939  1.00 15.25 ? 135 ILE   A H    1 
ATOM   1913 H  HA   . ILE   A 1 155 ? 1.011   19.578 8.645  1.00 16.74 ? 135 ILE   A HA   1 
ATOM   1914 H  HB   . ILE   A 1 155 ? 3.452   18.281 9.214  1.00 13.40 ? 135 ILE   A HB   1 
ATOM   1915 H  HG12 . ILE   A 1 155 ? 0.899   17.136 9.572  1.00 14.14 ? 135 ILE   A HG12 1 
ATOM   1916 H  HG13 . ILE   A 1 155 ? 1.771   16.851 8.275  1.00 14.14 ? 135 ILE   A HG13 1 
ATOM   1917 H  HG21 . ILE   A 1 155 ? 2.481   18.171 11.460 1.00 20.32 ? 135 ILE   A HG21 1 
ATOM   1918 H  HG22 . ILE   A 1 155 ? 3.063   19.578 11.016 1.00 20.32 ? 135 ILE   A HG22 1 
ATOM   1919 H  HG23 . ILE   A 1 155 ? 1.497   19.311 10.959 1.00 20.32 ? 135 ILE   A HG23 1 
ATOM   1920 H  HD11 . ILE   A 1 155 ? 2.116   15.069 9.655  1.00 18.34 ? 135 ILE   A HD11 1 
ATOM   1921 H  HD12 . ILE   A 1 155 ? 3.451   15.928 9.727  1.00 18.34 ? 135 ILE   A HD12 1 
ATOM   1922 H  HD13 . ILE   A 1 155 ? 2.387   16.013 10.904 1.00 18.34 ? 135 ILE   A HD13 1 
ATOM   1923 N  N    . LYS   A 1 156 ? 1.864   21.793 9.132  1.00 12.46 ? 136 LYS   A N    1 
ATOM   1924 C  CA   . LYS   A 1 156 ? 2.377   23.092 9.547  1.00 13.49 ? 136 LYS   A CA   1 
ATOM   1925 C  C    . LYS   A 1 156 ? 2.715   23.123 11.034 1.00 15.80 ? 136 LYS   A C    1 
ATOM   1926 O  O    . LYS   A 1 156 ? 3.679   23.784 11.434 1.00 14.68 ? 136 LYS   A O    1 
ATOM   1927 C  CB   . LYS   A 1 156 ? 1.348   24.178 9.215  1.00 19.98 ? 136 LYS   A CB   1 
ATOM   1928 C  CG   . LYS   A 1 156 ? 1.722   25.584 9.657  1.00 26.81 ? 136 LYS   A CG   1 
ATOM   1929 C  CD   . LYS   A 1 156 ? 2.922   26.119 8.891  1.00 35.39 ? 136 LYS   A CD   1 
ATOM   1930 C  CE   . LYS   A 1 156 ? 3.233   27.552 9.301  1.00 45.95 ? 136 LYS   A CE   1 
ATOM   1931 N  NZ   . LYS   A 1 156 ? 2.077   28.464 9.060  1.00 58.82 ? 136 LYS   A NZ   1 
ATOM   1932 H  H    . LYS   A 1 156 ? 1.010   21.726 9.209  1.00 14.97 ? 136 LYS   A H    1 
ATOM   1933 H  HA   . LYS   A 1 156 ? 3.188   23.285 9.051  1.00 16.21 ? 136 LYS   A HA   1 
ATOM   1934 H  HB2  . LYS   A 1 156 ? 1.222   24.199 8.253  1.00 24.00 ? 136 LYS   A HB2  1 
ATOM   1935 H  HB3  . LYS   A 1 156 ? 0.510   23.950 9.647  1.00 24.00 ? 136 LYS   A HB3  1 
ATOM   1936 H  HG2  . LYS   A 1 156 ? 0.971   26.173 9.489  1.00 32.19 ? 136 LYS   A HG2  1 
ATOM   1937 H  HG3  . LYS   A 1 156 ? 1.938   25.586 10.602 1.00 32.19 ? 136 LYS   A HG3  1 
ATOM   1938 H  HD2  . LYS   A 1 156 ? 3.698   25.571 9.084  1.00 42.48 ? 136 LYS   A HD2  1 
ATOM   1939 H  HD3  . LYS   A 1 156 ? 2.729   26.108 7.941  1.00 42.48 ? 136 LYS   A HD3  1 
ATOM   1940 H  HE2  . LYS   A 1 156 ? 3.444   27.574 10.248 1.00 55.15 ? 136 LYS   A HE2  1 
ATOM   1941 H  HE3  . LYS   A 1 156 ? 3.987   27.875 8.783  1.00 55.15 ? 136 LYS   A HE3  1 
ATOM   1942 H  HZ1  . LYS   A 1 156 ? 2.312   29.305 9.233  1.00 70.60 ? 136 LYS   A HZ1  1 
ATOM   1943 H  HZ2  . LYS   A 1 156 ? 1.816   28.406 8.211  1.00 70.60 ? 136 LYS   A HZ2  1 
ATOM   1944 H  HZ3  . LYS   A 1 156 ? 1.397   28.240 9.588  1.00 70.60 ? 136 LYS   A HZ3  1 
ATOM   1945 N  N    . GLU   A 1 157 ? 1.935   22.432 11.865 1.00 14.20 ? 137 GLU   A N    1 
ATOM   1946 C  CA   . GLU   A 1 157 ? 2.183   22.413 13.301 1.00 12.64 ? 137 GLU   A CA   1 
ATOM   1947 C  C    . GLU   A 1 157 ? 1.744   21.074 13.863 1.00 11.30 ? 137 GLU   A C    1 
ATOM   1948 O  O    . GLU   A 1 157 ? 0.564   20.712 13.768 1.00 14.23 ? 137 GLU   A O    1 
ATOM   1949 C  CB   . GLU   A 1 157 ? 1.441   23.538 14.021 1.00 15.24 ? 137 GLU   A CB   1 
ATOM   1950 C  CG   . GLU   A 1 157 ? 1.775   23.630 15.491 1.00 15.41 ? 137 GLU   A CG   1 
ATOM   1951 C  CD   . GLU   A 1 157 ? 0.830   24.526 16.254 1.00 17.77 ? 137 GLU   A CD   1 
ATOM   1952 O  OE1  . GLU   A 1 157 ? -0.374  24.185 16.336 1.00 19.50 ? 137 GLU   A OE1  1 
ATOM   1953 O  OE2  . GLU   A 1 157 ? 1.297   25.568 16.764 1.00 22.73 ? 137 GLU   A OE2  1 
ATOM   1954 H  H    . GLU   A 1 157 ? 1.255   21.966 11.619 1.00 17.06 ? 137 GLU   A H    1 
ATOM   1955 H  HA   . GLU   A 1 157 ? 3.132   22.520 13.466 1.00 15.19 ? 137 GLU   A HA   1 
ATOM   1956 H  HB2  . GLU   A 1 157 ? 1.676   24.384 13.608 1.00 18.30 ? 137 GLU   A HB2  1 
ATOM   1957 H  HB3  . GLU   A 1 157 ? 0.486   23.386 13.941 1.00 18.30 ? 137 GLU   A HB3  1 
ATOM   1958 H  HG2  . GLU   A 1 157 ? 1.729   22.747 15.889 1.00 18.51 ? 137 GLU   A HG2  1 
ATOM   1959 H  HG3  . GLU   A 1 157 ? 2.671   23.990 15.588 1.00 18.51 ? 137 GLU   A HG3  1 
ATOM   1960 N  N    . GLN   A 1 158 ? 2.691   20.356 14.456 1.00 12.42 ? 138 GLN   A N    1 
ATOM   1961 C  CA   . GLN   A 1 158 ? 2.425   19.154 15.230 1.00 11.04 ? 138 GLN   A CA   1 
ATOM   1962 C  C    . GLN   A 1 158 ? 2.781   19.439 16.683 1.00 11.97 ? 138 GLN   A C    1 
ATOM   1963 O  O    . GLN   A 1 158 ? 3.827   20.029 16.965 1.00 12.93 ? 138 GLN   A O    1 
ATOM   1964 C  CB   . GLN   A 1 158 ? 3.238   17.977 14.695 1.00 13.09 ? 138 GLN   A CB   1 
ATOM   1965 C  CG   . GLN   A 1 158 ? 3.091   16.699 15.496 1.00 13.50 ? 138 GLN   A CG   1 
ATOM   1966 C  CD   . GLN   A 1 158 ? 4.049   16.607 16.675 1.00 18.56 ? 138 GLN   A CD   1 
ATOM   1967 O  OE1  . GLN   A 1 158 ? 5.078   17.295 16.730 1.00 18.83 ? 138 GLN   A OE1  1 
ATOM   1968 N  NE2  . GLN   A 1 158 ? 3.725   15.735 17.614 1.00 17.79 ? 138 GLN   A NE2  1 
ATOM   1969 H  H    . GLN   A 1 158 ? 3.527   20.555 14.421 1.00 14.92 ? 138 GLN   A H    1 
ATOM   1970 H  HA   . GLN   A 1 158 ? 1.484   18.931 15.175 1.00 13.27 ? 138 GLN   A HA   1 
ATOM   1971 H  HB2  . GLN   A 1 158 ? 2.950   17.789 13.788 1.00 15.72 ? 138 GLN   A HB2  1 
ATOM   1972 H  HB3  . GLN   A 1 158 ? 4.176   18.222 14.694 1.00 15.72 ? 138 GLN   A HB3  1 
ATOM   1973 H  HG2  . GLN   A 1 158 ? 2.187   16.649 15.843 1.00 16.22 ? 138 GLN   A HG2  1 
ATOM   1974 H  HG3  . GLN   A 1 158 ? 3.263   15.943 14.914 1.00 16.22 ? 138 GLN   A HG3  1 
ATOM   1975 H  HE21 . GLN   A 1 158 ? 3.005   15.273 17.539 1.00 21.37 ? 138 GLN   A HE21 1 
ATOM   1976 H  HE22 . GLN   A 1 158 ? 4.229   15.638 18.304 1.00 21.37 ? 138 GLN   A HE22 1 
ATOM   1977 N  N    . ARG   A 1 159 ? 1.900   19.050 17.597 1.00 10.59 ? 139 ARG   A N    1 
ATOM   1978 C  CA   . ARG   A 1 159 ? 2.138   19.217 19.020 1.00 10.88 ? 139 ARG   A CA   1 
ATOM   1979 C  C    . ARG   A 1 159 ? 1.750   17.931 19.727 1.00 12.60 ? 139 ARG   A C    1 
ATOM   1980 O  O    . ARG   A 1 159 ? 0.691   17.369 19.438 1.00 12.94 ? 139 ARG   A O    1 
ATOM   1981 C  CB   . ARG   A 1 159 ? 1.315   20.374 19.599 1.00 13.72 ? 139 ARG   A CB   1 
ATOM   1982 C  CG   . ARG   A 1 159 ? 1.508   21.709 18.915 1.00 12.88 ? 139 ARG   A CG   1 
ATOM   1983 C  CD   . ARG   A 1 159 ? 0.566   22.749 19.513 1.00 12.05 ? 139 ARG   A CD   1 
ATOM   1984 N  NE   . ARG   A 1 159 ? -0.820  22.435 19.182 1.00 13.73 ? 139 ARG   A NE   1 
ATOM   1985 C  CZ   . ARG   A 1 159 ? -1.880  22.901 19.829 1.00 11.77 ? 139 ARG   A CZ   1 
ATOM   1986 N  NH1  . ARG   A 1 159 ? -1.763  23.762 20.829 1.00 14.02 ? 139 ARG   A NH1  1 
ATOM   1987 N  NH2  . ARG   A 1 159 ? -3.091  22.480 19.474 1.00 13.00 ? 139 ARG   A NH2  1 
ATOM   1988 H  H    . ARG   A 1 159 ? 1.145   18.681 17.413 1.00 12.73 ? 139 ARG   A H    1 
ATOM   1989 H  HA   . ARG   A 1 159 ? 3.079   19.390 19.181 1.00 13.07 ? 139 ARG   A HA   1 
ATOM   1990 H  HB2  . ARG   A 1 159 ? 0.375   20.144 19.533 1.00 16.48 ? 139 ARG   A HB2  1 
ATOM   1991 H  HB3  . ARG   A 1 159 ? 1.557   20.487 20.532 1.00 16.48 ? 139 ARG   A HB3  1 
ATOM   1992 H  HG2  . ARG   A 1 159 ? 2.420   22.010 19.042 1.00 15.48 ? 139 ARG   A HG2  1 
ATOM   1993 H  HG3  . ARG   A 1 159 ? 1.308   21.621 17.970 1.00 15.48 ? 139 ARG   A HG3  1 
ATOM   1994 H  HD2  . ARG   A 1 159 ? 0.659   22.751 20.479 1.00 14.47 ? 139 ARG   A HD2  1 
ATOM   1995 H  HD3  . ARG   A 1 159 ? 0.778   23.623 19.151 1.00 14.47 ? 139 ARG   A HD3  1 
ATOM   1996 H  HE   . ARG   A 1 159 ? -0.960  21.908 18.517 1.00 16.50 ? 139 ARG   A HE   1 
ATOM   1997 H  HH11 . ARG   A 1 159 ? -0.986  24.039 21.072 1.00 16.84 ? 139 ARG   A HH11 1 
ATOM   1998 H  HH12 . ARG   A 1 159 ? -2.466  24.049 21.233 1.00 16.84 ? 139 ARG   A HH12 1 
ATOM   1999 H  HH21 . ARG   A 1 159 ? -3.179  21.921 18.826 1.00 15.62 ? 139 ARG   A HH21 1 
ATOM   2000 H  HH22 . ARG   A 1 159 ? -3.787  22.776 19.884 1.00 15.62 ? 139 ARG   A HH22 1 
ATOM   2001 N  N    . GLU   A 1 160 ? 2.579   17.462 20.656 1.00 11.59 ? 140 GLU   A N    1 
ATOM   2002 C  CA   . GLU   A 1 160 ? 2.183   16.314 21.460 1.00 14.13 ? 140 GLU   A CA   1 
ATOM   2003 C  C    . GLU   A 1 160 ? 2.087   16.691 22.931 1.00 13.50 ? 140 GLU   A C    1 
ATOM   2004 O  O    . GLU   A 1 160 ? 2.848   17.527 23.432 1.00 11.76 ? 140 GLU   A O    1 
ATOM   2005 C  CB   . GLU   A 1 160 ? 3.100   15.114 21.263 1.00 20.89 ? 140 GLU   A CB   1 
ATOM   2006 C  CG   . GLU   A 1 160 ? 4.521   15.256 21.652 1.00 18.55 ? 140 GLU   A CG   1 
ATOM   2007 C  CD   . GLU   A 1 160 ? 5.371   14.224 20.932 1.00 33.20 ? 140 GLU   A CD   1 
ATOM   2008 O  OE1  . GLU   A 1 160 ? 5.460   14.286 19.686 1.00 30.19 ? 140 GLU   A OE1  1 
ATOM   2009 O  OE2  . GLU   A 1 160 ? 5.929   13.335 21.603 1.00 26.20 ? 140 GLU   A OE2  1 
ATOM   2010 H  H    . GLU   A 1 160 ? 3.357   17.782 20.836 1.00 13.92 ? 140 GLU   A H    1 
ATOM   2011 H  HA   . GLU   A 1 160 ? 1.296   16.034 21.187 1.00 16.97 ? 140 GLU   A HA   1 
ATOM   2012 H  HB2  . GLU   A 1 160 ? 2.739   14.375 21.777 1.00 25.09 ? 140 GLU   A HB2  1 
ATOM   2013 H  HB3  . GLU   A 1 160 ? 3.087   14.881 20.322 1.00 25.09 ? 140 GLU   A HB3  1 
ATOM   2014 H  HG2  . GLU   A 1 160 ? 4.837   16.139 21.406 1.00 22.28 ? 140 GLU   A HG2  1 
ATOM   2015 H  HG3  . GLU   A 1 160 ? 4.611   15.117 22.608 1.00 22.28 ? 140 GLU   A HG3  1 
ATOM   2016 N  N    . PHE   A 1 161 ? 1.094   16.095 23.588 1.00 11.45 ? 141 PHE   A N    1 
ATOM   2017 C  CA   . PHE   A 1 161 ? 0.745   16.379 24.968 1.00 12.78 ? 141 PHE   A CA   1 
ATOM   2018 C  C    . PHE   A 1 161 ? 0.715   15.072 25.743 1.00 11.16 ? 141 PHE   A C    1 
ATOM   2019 O  O    . PHE   A 1 161 ? 0.035   14.123 25.340 1.00 12.55 ? 141 PHE   A O    1 
ATOM   2020 C  CB   . PHE   A 1 161 ? -0.635  17.039 25.071 1.00 10.60 ? 141 PHE   A CB   1 
ATOM   2021 C  CG   . PHE   A 1 161 ? -0.787  18.298 24.268 1.00 12.28 ? 141 PHE   A CG   1 
ATOM   2022 C  CD1  . PHE   A 1 161 ? -1.111  18.248 22.920 1.00 10.73 ? 141 PHE   A CD1  1 
ATOM   2023 C  CD2  . PHE   A 1 161 ? -0.647  19.536 24.868 1.00 14.40 ? 141 PHE   A CD2  1 
ATOM   2024 C  CE1  . PHE   A 1 161 ? -1.276  19.404 22.194 1.00 12.31 ? 141 PHE   A CE1  1 
ATOM   2025 C  CE2  . PHE   A 1 161 ? -0.810  20.693 24.146 1.00 16.04 ? 141 PHE   A CE2  1 
ATOM   2026 C  CZ   . PHE   A 1 161 ? -1.125  20.629 22.809 1.00 12.27 ? 141 PHE   A CZ   1 
ATOM   2027 H  H    . PHE   A 1 161 ? 0.589   15.496 23.233 1.00 13.75 ? 141 PHE   A H    1 
ATOM   2028 H  HA   . PHE   A 1 161 ? 1.407   16.967 25.365 1.00 15.35 ? 141 PHE   A HA   1 
ATOM   2029 H  HB2  . PHE   A 1 161 ? -1.304  16.409 24.759 1.00 12.74 ? 141 PHE   A HB2  1 
ATOM   2030 H  HB3  . PHE   A 1 161 ? -0.804  17.261 26.000 1.00 12.74 ? 141 PHE   A HB3  1 
ATOM   2031 H  HD1  . PHE   A 1 161 ? -1.218  17.424 22.503 1.00 12.90 ? 141 PHE   A HD1  1 
ATOM   2032 H  HD2  . PHE   A 1 161 ? -0.438  19.586 25.773 1.00 17.29 ? 141 PHE   A HD2  1 
ATOM   2033 H  HE1  . PHE   A 1 161 ? -1.486  19.360 21.289 1.00 14.79 ? 141 PHE   A HE1  1 
ATOM   2034 H  HE2  . PHE   A 1 161 ? -0.706  21.519 24.561 1.00 19.26 ? 141 PHE   A HE2  1 
ATOM   2035 H  HZ   . PHE   A 1 161 ? -1.230  21.412 22.318 1.00 14.74 ? 141 PHE   A HZ   1 
ATOM   2036 N  N    . MET   A 1 162 ? 1.417   15.028 26.866 1.00 10.68 ? 142 MET   A N    1 
ATOM   2037 C  CA   . MET   A 1 162 ? 1.376   13.854 27.719 1.00 11.51 ? 142 MET   A CA   1 
ATOM   2038 C  C    . MET   A 1 162 ? 1.504   14.312 29.165 1.00 14.53 ? 142 MET   A C    1 
ATOM   2039 O  O    . MET   A 1 162 ? 1.562   15.510 29.458 1.00 13.73 ? 142 MET   A O    1 
ATOM   2040 C  CB   . MET   A 1 162 ? 2.473   12.851 27.342 1.00 12.61 ? 142 MET   A CB   1 
ATOM   2041 C  CG   . MET   A 1 162 ? 3.860   13.450 27.160 1.00 13.12 ? 142 MET   A CG   1 
ATOM   2042 S  SD   . MET   A 1 162 ? 4.539   14.138 28.684 1.00 13.58 ? 142 MET   A SD   1 
ATOM   2043 C  CE   . MET   A 1 162 ? 6.284   14.191 28.286 1.00 14.11 ? 142 MET   A CE   1 
ATOM   2044 H  H    . MET   A 1 162 ? 1.922   15.661 27.155 1.00 12.83 ? 142 MET   A H    1 
ATOM   2045 H  HA   . MET   A 1 162 ? 0.520   13.413 27.607 1.00 13.83 ? 142 MET   A HA   1 
ATOM   2046 H  HB2  . MET   A 1 162 ? 2.534   12.177 28.036 1.00 15.16 ? 142 MET   A HB2  1 
ATOM   2047 H  HB3  . MET   A 1 162 ? 2.227   12.430 26.504 1.00 15.16 ? 142 MET   A HB3  1 
ATOM   2048 H  HG2  . MET   A 1 162 ? 4.463   12.756 26.852 1.00 15.76 ? 142 MET   A HG2  1 
ATOM   2049 H  HG3  . MET   A 1 162 ? 3.815   14.163 26.504 1.00 15.76 ? 142 MET   A HG3  1 
ATOM   2050 H  HE1  . MET   A 1 162 ? 6.747   14.703 28.967 1.00 16.95 ? 142 MET   A HE1  1 
ATOM   2051 H  HE2  . MET   A 1 162 ? 6.629   13.285 28.262 1.00 16.95 ? 142 MET   A HE2  1 
ATOM   2052 H  HE3  . MET   A 1 162 ? 6.399   14.612 27.421 1.00 16.95 ? 142 MET   A HE3  1 
ATOM   2053 N  N    . ASN   A 1 163 ? 1.554   13.333 30.064 1.00 13.92 ? 143 ASN   A N    1 
ATOM   2054 C  CA   . ASN   A 1 163 ? 1.781   13.584 31.484 1.00 10.58 ? 143 ASN   A CA   1 
ATOM   2055 C  C    . ASN   A 1 163 ? 3.260   13.395 31.793 1.00 15.61 ? 143 ASN   A C    1 
ATOM   2056 O  O    . ASN   A 1 163 ? 3.741   12.250 31.784 1.00 12.06 ? 143 ASN   A O    1 
ATOM   2057 C  CB   . ASN   A 1 163 ? 0.947   12.636 32.310 1.00 14.20 ? 143 ASN   A CB   1 
ATOM   2058 C  CG   . ASN   A 1 163 ? 1.144   12.805 33.792 1.00 11.92 ? 143 ASN   A CG   1 
ATOM   2059 O  OD1  . ASN   A 1 163 ? 1.972   13.599 34.248 1.00 12.51 ? 143 ASN   A OD1  1 
ATOM   2060 N  ND2  . ASN   A 1 163 ? 0.364   12.062 34.561 1.00 16.00 ? 143 ASN   A ND2  1 
ATOM   2061 H  H    . ASN   A 1 163 ? 1.457   12.500 29.873 1.00 16.72 ? 143 ASN   A H    1 
ATOM   2062 H  HA   . ASN   A 1 163 ? 1.512   14.488 31.703 1.00 12.72 ? 143 ASN   A HA   1 
ATOM   2063 H  HB2  . ASN   A 1 163 ? 0.010   12.791 32.114 1.00 17.06 ? 143 ASN   A HB2  1 
ATOM   2064 H  HB3  . ASN   A 1 163 ? 1.186   11.725 32.080 1.00 17.06 ? 143 ASN   A HB3  1 
ATOM   2065 H  HD21 . ASN   A 1 163 ? 0.428   12.115 35.417 1.00 19.22 ? 143 ASN   A HD21 1 
ATOM   2066 H  HD22 . ASN   A 1 163 ? -0.203  11.522 34.205 1.00 19.22 ? 143 ASN   A HD22 1 
ATOM   2067 N  N    . PRO   A 1 164 ? 4.015   14.459 32.073 1.00 11.69 ? 144 PRO   A N    1 
ATOM   2068 C  CA   . PRO   A 1 164 ? 5.462   14.281 32.251 1.00 13.52 ? 144 PRO   A CA   1 
ATOM   2069 C  C    . PRO   A 1 164 ? 5.820   13.400 33.431 1.00 13.08 ? 144 PRO   A C    1 
ATOM   2070 O  O    . PRO   A 1 164 ? 6.929   12.848 33.446 1.00 12.20 ? 144 PRO   A O    1 
ATOM   2071 C  CB   . PRO   A 1 164 ? 5.981   15.714 32.426 1.00 13.33 ? 144 PRO   A CB   1 
ATOM   2072 C  CG   . PRO   A 1 164 ? 4.958   16.566 31.740 1.00 16.21 ? 144 PRO   A CG   1 
ATOM   2073 C  CD   . PRO   A 1 164 ? 3.638   15.885 32.007 1.00 12.79 ? 144 PRO   A CD   1 
ATOM   2074 H  HA   . PRO   A 1 164 ? 5.850   13.902 31.447 1.00 16.24 ? 144 PRO   A HA   1 
ATOM   2075 H  HB2  . PRO   A 1 164 ? 6.035   15.932 33.370 1.00 16.02 ? 144 PRO   A HB2  1 
ATOM   2076 H  HB3  . PRO   A 1 164 ? 6.848   15.805 32.000 1.00 16.02 ? 144 PRO   A HB3  1 
ATOM   2077 H  HG2  . PRO   A 1 164 ? 4.967   17.458 32.120 1.00 19.47 ? 144 PRO   A HG2  1 
ATOM   2078 H  HG3  . PRO   A 1 164 ? 5.142   16.596 30.788 1.00 19.47 ? 144 PRO   A HG3  1 
ATOM   2079 H  HD2  . PRO   A 1 164 ? 3.269   16.179 32.854 1.00 15.36 ? 144 PRO   A HD2  1 
ATOM   2080 H  HD3  . PRO   A 1 164 ? 3.025   16.046 31.274 1.00 15.36 ? 144 PRO   A HD3  1 
ATOM   2081 N  N    . CYS   A 1 165 ? 4.913   13.216 34.397 1.00 10.08 ? 145 CYS   A N    1 
ATOM   2082 C  CA   . CYS   A 1 165 ? 5.230   12.354 35.528 1.00 14.95 ? 145 CYS   A CA   1 
ATOM   2083 C  C    . CYS   A 1 165 ? 5.600   10.945 35.084 1.00 14.73 ? 145 CYS   A C    1 
ATOM   2084 O  O    . CYS   A 1 165 ? 6.456   10.307 35.708 1.00 15.43 ? 145 CYS   A O    1 
ATOM   2085 C  CB   . CYS   A 1 165 ? 4.056   12.321 36.509 1.00 14.94 ? 145 CYS   A CB   1 
ATOM   2086 S  SG   . CYS   A 1 165 ? 3.707   13.934 37.243 1.00 16.39 ? 145 CYS   A SG   1 
ATOM   2087 H  H    . CYS   A 1 165 ? 4.130   13.570 34.418 1.00 12.12 ? 145 CYS   A H    1 
ATOM   2088 H  HA   . CYS   A 1 165 ? 5.993   12.724 35.996 1.00 17.96 ? 145 CYS   A HA   1 
ATOM   2089 H  HB2  . CYS   A 1 165 ? 3.260   12.028 36.039 1.00 17.95 ? 145 CYS   A HB2  1 
ATOM   2090 H  HB3  . CYS   A 1 165 ? 4.263   11.703 37.228 1.00 17.95 ? 145 CYS   A HB3  1 
ATOM   2091 H  HG   . CYS   A 1 165 ? 2.573   13.986 37.627 1.00 19.69 ? 145 CYS   A HG   1 
ATOM   2092 N  N    . GLU   A 1 166 ? 4.980   10.434 34.016 1.00 15.29 ? 146 GLU   A N    1 
ATOM   2093 C  CA   . GLU   A 1 166 ? 5.346   9.093  33.567 1.00 12.71 ? 146 GLU   A CA   1 
ATOM   2094 C  C    . GLU   A 1 166 ? 6.740   9.077  32.948 1.00 16.23 ? 146 GLU   A C    1 
ATOM   2095 O  O    . GLU   A 1 166 ? 7.451   8.070  33.046 1.00 16.47 ? 146 GLU   A O    1 
ATOM   2096 C  CB   . GLU   A 1 166 ? 4.314   8.555  32.577 1.00 18.12 ? 146 GLU   A CB   1 
ATOM   2097 C  CG   . GLU   A 1 166 ? 2.940   8.338  33.196 1.00 20.09 ? 146 GLU   A CG   1 
ATOM   2098 C  CD   . GLU   A 1 166 ? 3.002   7.447  34.422 1.00 32.07 ? 146 GLU   A CD   1 
ATOM   2099 O  OE1  . GLU   A 1 166 ? 3.448   6.291  34.291 1.00 32.63 ? 146 GLU   A OE1  1 
ATOM   2100 O  OE2  . GLU   A 1 166 ? 2.651   7.912  35.525 1.00 43.87 ? 146 GLU   A OE2  1 
ATOM   2101 H  H    . GLU   A 1 166 ? 4.370   10.826 33.553 1.00 18.37 ? 146 GLU   A H    1 
ATOM   2102 H  HA   . GLU   A 1 166 ? 5.368   8.503  34.336 1.00 15.27 ? 146 GLU   A HA   1 
ATOM   2103 H  HB2  . GLU   A 1 166 ? 4.216   9.189  31.850 1.00 21.76 ? 146 GLU   A HB2  1 
ATOM   2104 H  HB3  . GLU   A 1 166 ? 4.624   7.703  32.232 1.00 21.76 ? 146 GLU   A HB3  1 
ATOM   2105 H  HG2  . GLU   A 1 166 ? 2.572   9.195  33.463 1.00 24.12 ? 146 GLU   A HG2  1 
ATOM   2106 H  HG3  . GLU   A 1 166 ? 2.360   7.915  32.544 1.00 24.12 ? 146 GLU   A HG3  1 
ATOM   2107 N  N    . GLN   A 1 167 ? 7.158   10.176 32.316 1.00 11.67 ? 147 GLN   A N    1 
ATOM   2108 C  CA   . GLN   A 1 167 ? 8.521   10.215 31.805 1.00 13.34 ? 147 GLN   A CA   1 
ATOM   2109 C  C    . GLN   A 1 167 ? 9.530   10.331 32.945 1.00 16.53 ? 147 GLN   A C    1 
ATOM   2110 O  O    . GLN   A 1 167 ? 10.589  9.695  32.903 1.00 16.43 ? 147 GLN   A O    1 
ATOM   2111 C  CB   . GLN   A 1 167 ? 8.693   11.353 30.803 1.00 10.85 ? 147 GLN   A CB   1 
ATOM   2112 C  CG   . GLN   A 1 167 ? 9.978   11.180 30.000 1.00 16.43 ? 147 GLN   A CG   1 
ATOM   2113 C  CD   . GLN   A 1 167 ? 10.054  12.055 28.778 1.00 19.67 ? 147 GLN   A CD   1 
ATOM   2114 O  OE1  . GLN   A 1 167 ? 9.055   12.604 28.325 1.00 18.40 ? 147 GLN   A OE1  1 
ATOM   2115 N  NE2  . GLN   A 1 167 ? 11.262  12.184 28.226 1.00 17.63 ? 147 GLN   A NE2  1 
ATOM   2116 H  H    . GLN   A 1 167 ? 6.690   10.884 32.176 1.00 14.02 ? 147 GLN   A H    1 
ATOM   2117 H  HA   . GLN   A 1 167 ? 8.700   9.384  31.339 1.00 16.02 ? 147 GLN   A HA   1 
ATOM   2118 H  HB2  . GLN   A 1 167 ? 7.944   11.355 30.186 1.00 13.04 ? 147 GLN   A HB2  1 
ATOM   2119 H  HB3  . GLN   A 1 167 ? 8.741   12.197 31.279 1.00 13.04 ? 147 GLN   A HB3  1 
ATOM   2120 H  HG2  . GLN   A 1 167 ? 10.733  11.398 30.568 1.00 19.73 ? 147 GLN   A HG2  1 
ATOM   2121 H  HG3  . GLN   A 1 167 ? 10.043  10.258 29.707 1.00 19.73 ? 147 GLN   A HG3  1 
ATOM   2122 H  HE21 . GLN   A 1 167 ? 11.938  11.782 28.573 1.00 21.17 ? 147 GLN   A HE21 1 
ATOM   2123 H  HE22 . GLN   A 1 167 ? 11.365  12.672 27.525 1.00 21.17 ? 147 GLN   A HE22 1 
ATOM   2124 N  N    . PHE   A 1 168 ? 9.216   11.127 33.978 1.00 12.93 ? 148 PHE   A N    1 
ATOM   2125 C  CA   . PHE   A 1 168 ? 10.055  11.146 35.178 1.00 13.32 ? 148 PHE   A CA   1 
ATOM   2126 C  C    . PHE   A 1 168 ? 10.277  9.725  35.704 1.00 16.48 ? 148 PHE   A C    1 
ATOM   2127 O  O    . PHE   A 1 168 ? 11.406  9.316  35.994 1.00 16.67 ? 148 PHE   A O    1 
ATOM   2128 C  CB   . PHE   A 1 168 ? 9.439   11.993 36.302 1.00 14.95 ? 148 PHE   A CB   1 
ATOM   2129 C  CG   . PHE   A 1 168 ? 9.203   13.441 35.957 1.00 13.64 ? 148 PHE   A CG   1 
ATOM   2130 C  CD1  . PHE   A 1 168 ? 9.934   14.082 34.973 1.00 17.89 ? 148 PHE   A CD1  1 
ATOM   2131 C  CD2  . PHE   A 1 168 ? 8.238   14.169 36.646 1.00 15.87 ? 148 PHE   A CD2  1 
ATOM   2132 C  CE1  . PHE   A 1 168 ? 9.694   15.417 34.665 1.00 22.23 ? 148 PHE   A CE1  1 
ATOM   2133 C  CE2  . PHE   A 1 168 ? 7.992   15.497 36.345 1.00 20.74 ? 148 PHE   A CE2  1 
ATOM   2134 C  CZ   . PHE   A 1 168 ? 8.721   16.125 35.358 1.00 27.25 ? 148 PHE   A CZ   1 
ATOM   2135 H  H    . PHE   A 1 168 ? 8.537   11.653 34.006 1.00 15.54 ? 148 PHE   A H    1 
ATOM   2136 H  HA   . PHE   A 1 168 ? 10.922  11.520 34.955 1.00 16.00 ? 148 PHE   A HA   1 
ATOM   2137 H  HB2  . PHE   A 1 168 ? 8.582   11.607 36.543 1.00 17.95 ? 148 PHE   A HB2  1 
ATOM   2138 H  HB3  . PHE   A 1 168 ? 10.033  11.968 37.068 1.00 17.95 ? 148 PHE   A HB3  1 
ATOM   2139 H  HD1  . PHE   A 1 168 ? 10.583  13.612 34.502 1.00 21.49 ? 148 PHE   A HD1  1 
ATOM   2140 H  HD2  . PHE   A 1 168 ? 7.738   13.751 37.310 1.00 19.06 ? 148 PHE   A HD2  1 
ATOM   2141 H  HE1  . PHE   A 1 168 ? 10.189  15.837 33.999 1.00 26.70 ? 148 PHE   A HE1  1 
ATOM   2142 H  HE2  . PHE   A 1 168 ? 7.341   15.968 36.814 1.00 24.91 ? 148 PHE   A HE2  1 
ATOM   2143 H  HZ   . PHE   A 1 168 ? 8.563   17.019 35.158 1.00 32.72 ? 148 PHE   A HZ   1 
ATOM   2144 N  N    . ARG   A 1 169 ? 9.191   8.962  35.851 1.00 16.62 ? 149 ARG   A N    1 
ATOM   2145 C  CA   . ARG   A 1 169 ? 9.306   7.600  36.366 1.00 18.90 ? 149 ARG   A CA   1 
ATOM   2146 C  C    . ARG   A 1 169 ? 10.225  6.743  35.504 1.00 19.57 ? 149 ARG   A C    1 
ATOM   2147 O  O    . ARG   A 1 169 ? 11.044  5.983  36.032 1.00 17.80 ? 149 ARG   A O    1 
ATOM   2148 C  CB   . ARG   A 1 169 ? 7.923   6.957  36.455 1.00 16.17 ? 149 ARG   A CB   1 
ATOM   2149 C  CG   . ARG   A 1 169 ? 7.104   7.439  37.624 1.00 20.06 ? 149 ARG   A CG   1 
ATOM   2150 C  CD   . ARG   A 1 169 ? 5.807   6.660  37.769 1.00 25.44 ? 149 ARG   A CD   1 
ATOM   2151 N  NE   . ARG   A 1 169 ? 5.153   7.067  39.005 1.00 32.54 ? 149 ARG   A NE   1 
ATOM   2152 C  CZ   . ARG   A 1 169 ? 4.296   8.075  39.108 1.00 28.48 ? 149 ARG   A CZ   1 
ATOM   2153 N  NH1  . ARG   A 1 169 ? 3.807   8.680  38.040 1.00 25.57 ? 149 ARG   A NH1  1 
ATOM   2154 N  NH2  . ARG   A 1 169 ? 3.928   8.489  40.316 1.00 32.83 ? 149 ARG   A NH2  1 
ATOM   2155 H  H    . ARG   A 1 169 ? 8.388   9.207  35.662 1.00 19.96 ? 149 ARG   A H    1 
ATOM   2156 H  HA   . ARG   A 1 169 ? 9.679   7.632  37.261 1.00 22.70 ? 149 ARG   A HA   1 
ATOM   2157 H  HB2  . ARG   A 1 169 ? 7.431   7.160  35.644 1.00 19.43 ? 149 ARG   A HB2  1 
ATOM   2158 H  HB3  . ARG   A 1 169 ? 8.030   5.997  36.543 1.00 19.43 ? 149 ARG   A HB3  1 
ATOM   2159 H  HG2  . ARG   A 1 169 ? 7.617   7.327  38.440 1.00 24.09 ? 149 ARG   A HG2  1 
ATOM   2160 H  HG3  . ARG   A 1 169 ? 6.882   8.374  37.494 1.00 24.09 ? 149 ARG   A HG3  1 
ATOM   2161 H  HD2  . ARG   A 1 169 ? 5.224   6.843  37.017 1.00 30.54 ? 149 ARG   A HD2  1 
ATOM   2162 H  HD3  . ARG   A 1 169 ? 6.004   5.712  37.823 1.00 30.54 ? 149 ARG   A HD3  1 
ATOM   2163 H  HE   . ARG   A 1 169 ? 5.335   6.623  39.719 1.00 39.07 ? 149 ARG   A HE   1 
ATOM   2164 H  HH11 . ARG   A 1 169 ? 4.042   8.430  37.252 1.00 30.70 ? 149 ARG   A HH11 1 
ATOM   2165 H  HH12 . ARG   A 1 169 ? 3.251   9.329  38.134 1.00 30.70 ? 149 ARG   A HH12 1 
ATOM   2166 H  HH21 . ARG   A 1 169 ? 4.236   8.098  41.017 1.00 39.42 ? 149 ARG   A HH21 1 
ATOM   2167 H  HH22 . ARG   A 1 169 ? 3.364   9.133  40.396 1.00 39.42 ? 149 ARG   A HH22 1 
ATOM   2168 N  N    . SER   A 1 170 ? 10.091  6.832  34.178 1.00 16.17 ? 150 SER   A N    1 
ATOM   2169 C  CA   . SER   A 1 170 ? 10.922  6.015  33.291 1.00 15.22 ? 150 SER   A CA   1 
ATOM   2170 C  C    . SER   A 1 170 ? 12.400  6.345  33.448 1.00 18.18 ? 150 SER   A C    1 
ATOM   2171 O  O    . SER   A 1 170 ? 13.261  5.505  33.161 1.00 19.70 ? 150 SER   A O    1 
ATOM   2172 C  CB   . SER   A 1 170 ? 10.503  6.208  31.830 1.00 17.18 ? 150 SER   A CB   1 
ATOM   2173 O  OG   . SER   A 1 170 ? 10.944  7.449  31.295 1.00 16.44 ? 150 SER   A OG   1 
ATOM   2174 H  H    . SER   A 1 170 ? 9.536   7.349  33.773 1.00 19.42 ? 150 SER   A H    1 
ATOM   2175 H  HA   . SER   A 1 170 ? 10.799  5.080  33.517 1.00 18.29 ? 150 SER   A HA   1 
ATOM   2176 H  HB2  . SER   A 1 170 ? 10.883  5.490  31.301 1.00 20.63 ? 150 SER   A HB2  1 
ATOM   2177 H  HB3  . SER   A 1 170 ? 9.535   6.174  31.778 1.00 20.63 ? 150 SER   A HB3  1 
ATOM   2178 H  HG   . SER   A 1 170 ? 10.620  8.084  31.738 1.00 19.75 ? 150 SER   A HG   1 
ATOM   2179 N  N    . LEU   A 1 171 ? 12.710  7.560  33.883 1.00 14.22 ? 151 LEU   A N    1 
ATOM   2180 C  CA   . LEU   A 1 171 ? 14.083  8.006  34.067 1.00 14.59 ? 151 LEU   A CA   1 
ATOM   2181 C  C    . LEU   A 1 171 ? 14.574  7.827  35.494 1.00 15.93 ? 151 LEU   A C    1 
ATOM   2182 O  O    . LEU   A 1 171 ? 15.701  8.235  35.805 1.00 19.57 ? 151 LEU   A O    1 
ATOM   2183 C  CB   . LEU   A 1 171 ? 14.216  9.478  33.678 1.00 14.70 ? 151 LEU   A CB   1 
ATOM   2184 C  CG   . LEU   A 1 171 ? 13.953  9.802  32.215 1.00 17.56 ? 151 LEU   A CG   1 
ATOM   2185 C  CD1  . LEU   A 1 171 ? 13.790  11.303 32.027 1.00 17.86 ? 151 LEU   A CD1  1 
ATOM   2186 C  CD2  . LEU   A 1 171 ? 15.079  9.280  31.337 1.00 19.74 ? 151 LEU   A CD2  1 
ATOM   2187 H  H    . LEU   A 1 171 ? 12.127  8.160  34.083 1.00 17.08 ? 151 LEU   A H    1 
ATOM   2188 H  HA   . LEU   A 1 171 ? 14.663  7.490  33.486 1.00 17.53 ? 151 LEU   A HA   1 
ATOM   2189 H  HB2  . LEU   A 1 171 ? 13.586  9.992  34.207 1.00 17.65 ? 151 LEU   A HB2  1 
ATOM   2190 H  HB3  . LEU   A 1 171 ? 15.119  9.768  33.881 1.00 17.65 ? 151 LEU   A HB3  1 
ATOM   2191 H  HG   . LEU   A 1 171 ? 13.129  9.372  31.937 1.00 21.09 ? 151 LEU   A HG   1 
ATOM   2192 H  HD11 . LEU   A 1 171 ? 13.629  11.488 31.088 1.00 21.45 ? 151 LEU   A HD11 1 
ATOM   2193 H  HD12 . LEU   A 1 171 ? 13.038  11.608 32.558 1.00 21.45 ? 151 LEU   A HD12 1 
ATOM   2194 H  HD13 . LEU   A 1 171 ? 14.602  11.747 32.317 1.00 21.45 ? 151 LEU   A HD13 1 
ATOM   2195 H  HD21 . LEU   A 1 171 ? 14.915  9.551  30.420 1.00 23.71 ? 151 LEU   A HD21 1 
ATOM   2196 H  HD22 . LEU   A 1 171 ? 15.919  9.653  31.647 1.00 23.71 ? 151 LEU   A HD22 1 
ATOM   2197 H  HD23 . LEU   A 1 171 ? 15.104  8.312  31.397 1.00 23.71 ? 151 LEU   A HD23 1 
ATOM   2198 N  N    . GLY   A 1 172 ? 13.757  7.255  36.373 1.00 15.11 ? 152 GLY   A N    1 
ATOM   2199 C  CA   . GLY   A 1 172 ? 14.138  7.105  37.758 1.00 20.04 ? 152 GLY   A CA   1 
ATOM   2200 C  C    . GLY   A 1 172 ? 14.053  8.371  38.576 1.00 22.81 ? 152 GLY   A C    1 
ATOM   2201 O  O    . GLY   A 1 172 ? 14.607  8.408  39.684 1.00 20.45 ? 152 GLY   A O    1 
ATOM   2202 H  H    . GLY   A 1 172 ? 12.976  6.946  36.187 1.00 18.15 ? 152 GLY   A H    1 
ATOM   2203 H  HA2  . GLY   A 1 172 ? 13.565  6.442  38.173 1.00 24.07 ? 152 GLY   A HA2  1 
ATOM   2204 H  HA3  . GLY   A 1 172 ? 15.052  6.782  37.801 1.00 24.07 ? 152 GLY   A HA3  1 
ATOM   2205 N  N    . ILE   A 1 173 ? 13.381  9.399  38.068 1.00 17.78 ? 153 ILE   A N    1 
ATOM   2206 C  CA   . ILE   A 1 173 ? 13.243  10.675 38.757 1.00 16.80 ? 153 ILE   A CA   1 
ATOM   2207 C  C    . ILE   A 1 173 ? 12.056  10.588 39.708 1.00 20.70 ? 153 ILE   A C    1 
ATOM   2208 O  O    . ILE   A 1 173 ? 10.980  10.115 39.323 1.00 18.68 ? 153 ILE   A O    1 
ATOM   2209 C  CB   . ILE   A 1 173 ? 13.047  11.817 37.746 1.00 15.34 ? 153 ILE   A CB   1 
ATOM   2210 C  CG1  . ILE   A 1 173 ? 14.283  11.962 36.857 1.00 16.07 ? 153 ILE   A CG1  1 
ATOM   2211 C  CG2  . ILE   A 1 173 ? 12.742  13.117 38.470 1.00 19.89 ? 153 ILE   A CG2  1 
ATOM   2212 C  CD1  . ILE   A 1 173 ? 14.065  12.865 35.676 1.00 19.11 ? 153 ILE   A CD1  1 
ATOM   2213 H  H    . ILE   A 1 173 ? 12.985  9.380  37.305 1.00 21.35 ? 153 ILE   A H    1 
ATOM   2214 H  HA   . ILE   A 1 173 ? 14.043  10.854 39.275 1.00 20.18 ? 153 ILE   A HA   1 
ATOM   2215 H  HB   . ILE   A 1 173 ? 12.290  11.597 37.181 1.00 18.43 ? 153 ILE   A HB   1 
ATOM   2216 H  HG12 . ILE   A 1 173 ? 15.008  12.332 37.385 1.00 19.30 ? 153 ILE   A HG12 1 
ATOM   2217 H  HG13 . ILE   A 1 173 ? 14.534  11.088 36.519 1.00 19.30 ? 153 ILE   A HG13 1 
ATOM   2218 H  HG21 . ILE   A 1 173 ? 12.838  13.856 37.850 1.00 23.89 ? 153 ILE   A HG21 1 
ATOM   2219 H  HG22 . ILE   A 1 173 ? 11.833  13.089 38.807 1.00 23.89 ? 153 ILE   A HG22 1 
ATOM   2220 H  HG23 . ILE   A 1 173 ? 13.366  13.222 39.205 1.00 23.89 ? 153 ILE   A HG23 1 
ATOM   2221 H  HD11 . ILE   A 1 173 ? 14.795  12.744 35.049 1.00 22.95 ? 153 ILE   A HD11 1 
ATOM   2222 H  HD12 . ILE   A 1 173 ? 13.224  12.633 35.253 1.00 22.95 ? 153 ILE   A HD12 1 
ATOM   2223 H  HD13 . ILE   A 1 173 ? 14.039  13.786 35.980 1.00 22.95 ? 153 ILE   A HD13 1 
ATOM   2224 N  N    . GLU   A 1 174 ? 12.251  11.049 40.944 1.00 20.85 ? 154 GLU   A N    1 
ATOM   2225 C  CA   . GLU   A 1 174 ? 11.188  11.029 41.941 1.00 19.52 ? 154 GLU   A CA   1 
ATOM   2226 C  C    . GLU   A 1 174 ? 10.061  11.966 41.529 1.00 17.64 ? 154 GLU   A C    1 
ATOM   2227 O  O    . GLU   A 1 174 ? 10.305  13.113 41.148 1.00 20.34 ? 154 GLU   A O    1 
ATOM   2228 C  CB   . GLU   A 1 174 ? 11.742  11.434 43.308 1.00 21.14 ? 154 GLU   A CB   1 
ATOM   2229 H  H    . GLU   A 1 174 ? 12.993  11.379 41.228 1.00 25.04 ? 154 GLU   A H    1 
ATOM   2230 H  HA   . GLU   A 1 174 ? 10.829  10.131 42.010 1.00 23.44 ? 154 GLU   A HA   1 
ATOM   2231 N  N    . VAL   A 1 175 ? 8.830   11.481 41.602 1.00 19.47 ? 155 VAL   A N    1 
ATOM   2232 C  CA   . VAL   A 1 175 ? 7.644   12.270 41.269 1.00 15.50 ? 155 VAL   A CA   1 
ATOM   2233 C  C    . VAL   A 1 175 ? 7.056   12.801 42.570 1.00 20.30 ? 155 VAL   A C    1 
ATOM   2234 O  O    . VAL   A 1 175 ? 6.806   12.007 43.489 1.00 18.21 ? 155 VAL   A O    1 
ATOM   2235 C  CB   . VAL   A 1 175 ? 6.598   11.440 40.500 1.00 17.34 ? 155 VAL   A CB   1 
ATOM   2236 C  CG1  . VAL   A 1 175 ? 5.371   12.288 40.167 1.00 17.45 ? 155 VAL   A CG1  1 
ATOM   2237 C  CG2  . VAL   A 1 175 ? 7.210   10.859 39.235 1.00 23.90 ? 155 VAL   A CG2  1 
ATOM   2238 H  H    . VAL   A 1 175 ? 8.648   10.677 41.848 1.00 23.38 ? 155 VAL   A H    1 
ATOM   2239 H  HA   . VAL   A 1 175 ? 7.909   13.013 40.707 1.00 18.61 ? 155 VAL   A HA   1 
ATOM   2240 H  HB   . VAL   A 1 175 ? 6.309   10.702 41.059 1.00 20.83 ? 155 VAL   A HB   1 
ATOM   2241 H  HG11 . VAL   A 1 175 ? 4.813   11.801 39.540 1.00 20.96 ? 155 VAL   A HG11 1 
ATOM   2242 H  HG12 . VAL   A 1 175 ? 4.875   12.464 40.982 1.00 20.96 ? 155 VAL   A HG12 1 
ATOM   2243 H  HG13 . VAL   A 1 175 ? 5.663   13.123 39.769 1.00 20.96 ? 155 VAL   A HG13 1 
ATOM   2244 H  HG21 . VAL   A 1 175 ? 6.522   10.387 38.740 1.00 28.69 ? 155 VAL   A HG21 1 
ATOM   2245 H  HG22 . VAL   A 1 175 ? 7.568   11.583 38.697 1.00 28.69 ? 155 VAL   A HG22 1 
ATOM   2246 H  HG23 . VAL   A 1 175 ? 7.921   10.246 39.480 1.00 28.69 ? 155 VAL   A HG23 1 
ATOM   2247 N  N    . PRO   A 1 176 ? 6.848   14.105 42.706 1.00 22.74 ? 156 PRO   A N    1 
ATOM   2248 C  CA   . PRO   A 1 176 ? 6.197   14.598 43.922 1.00 26.75 ? 156 PRO   A CA   1 
ATOM   2249 C  C    . PRO   A 1 176 ? 4.775   14.080 43.983 1.00 20.26 ? 156 PRO   A C    1 
ATOM   2250 O  O    . PRO   A 1 176 ? 4.158   13.767 42.962 1.00 18.52 ? 156 PRO   A O    1 
ATOM   2251 C  CB   . PRO   A 1 176 ? 6.242   16.121 43.769 1.00 38.88 ? 156 PRO   A CB   1 
ATOM   2252 C  CG   . PRO   A 1 176 ? 6.246   16.336 42.307 1.00 34.62 ? 156 PRO   A CG   1 
ATOM   2253 C  CD   . PRO   A 1 176 ? 7.055   15.189 41.725 1.00 27.93 ? 156 PRO   A CD   1 
ATOM   2254 H  HA   . PRO   A 1 176 ? 6.687   14.327 44.715 1.00 32.11 ? 156 PRO   A HA   1 
ATOM   2255 H  HB2  . PRO   A 1 176 ? 5.454   16.515 44.175 1.00 46.68 ? 156 PRO   A HB2  1 
ATOM   2256 H  HB3  . PRO   A 1 176 ? 7.052   16.470 44.173 1.00 46.68 ? 156 PRO   A HB3  1 
ATOM   2257 H  HG2  . PRO   A 1 176 ? 5.335   16.311 41.979 1.00 41.56 ? 156 PRO   A HG2  1 
ATOM   2258 H  HG3  . PRO   A 1 176 ? 6.662   17.188 42.103 1.00 41.56 ? 156 PRO   A HG3  1 
ATOM   2259 H  HD2  . PRO   A 1 176 ? 6.704   14.934 40.857 1.00 33.53 ? 156 PRO   A HD2  1 
ATOM   2260 H  HD3  . PRO   A 1 176 ? 7.994   15.427 41.675 1.00 33.53 ? 156 PRO   A HD3  1 
ATOM   2261 N  N    . GLU   A 1 177 ? 4.262   13.976 45.201 1.00 23.31 ? 157 GLU   A N    1 
ATOM   2262 C  CA   . GLU   A 1 177 ? 2.909   13.502 45.438 1.00 21.77 ? 157 GLU   A CA   1 
ATOM   2263 C  C    . GLU   A 1 177 ? 2.127   14.618 46.109 1.00 21.93 ? 157 GLU   A C    1 
ATOM   2264 O  O    . GLU   A 1 177 ? 2.575   15.175 47.114 1.00 30.07 ? 157 GLU   A O    1 
ATOM   2265 C  CB   . GLU   A 1 177 ? 2.896   12.250 46.317 1.00 38.18 ? 157 GLU   A CB   1 
ATOM   2266 H  H    . GLU   A 1 177 ? 4.688   14.178 45.920 1.00 28.00 ? 157 GLU   A H    1 
ATOM   2267 H  HA   . GLU   A 1 177 ? 2.481   13.290 44.594 1.00 26.14 ? 157 GLU   A HA   1 
ATOM   2268 N  N    . VAL   A 1 178 ? 0.978   14.963 45.536 1.00 17.51 ? 158 VAL   A N    1 
ATOM   2269 C  CA   . VAL   A 1 178 ? 0.065   15.873 46.213 1.00 17.37 ? 158 VAL   A CA   1 
ATOM   2270 C  C    . VAL   A 1 178 ? -0.560  15.132 47.385 1.00 17.15 ? 158 VAL   A C    1 
ATOM   2271 O  O    . VAL   A 1 178 ? -1.089  14.026 47.224 1.00 19.02 ? 158 VAL   A O    1 
ATOM   2272 C  CB   . VAL   A 1 178 ? -0.997  16.393 45.235 1.00 19.84 ? 158 VAL   A CB   1 
ATOM   2273 C  CG1  . VAL   A 1 178 ? -2.040  17.230 45.957 1.00 19.99 ? 158 VAL   A CG1  1 
ATOM   2274 C  CG2  . VAL   A 1 178 ? -0.324  17.191 44.107 1.00 22.42 ? 158 VAL   A CG2  1 
ATOM   2275 H  H    . VAL   A 1 178 ? 0.708   14.688 44.767 1.00 21.04 ? 158 VAL   A H    1 
ATOM   2276 H  HA   . VAL   A 1 178 ? 0.561   16.631 46.559 1.00 20.86 ? 158 VAL   A HA   1 
ATOM   2277 H  HB   . VAL   A 1 178 ? -1.450  15.635 44.833 1.00 23.82 ? 158 VAL   A HB   1 
ATOM   2278 H  HG11 . VAL   A 1 178 ? -2.568  17.709 45.299 1.00 24.01 ? 158 VAL   A HG11 1 
ATOM   2279 H  HG12 . VAL   A 1 178 ? -2.614  16.646 46.477 1.00 24.01 ? 158 VAL   A HG12 1 
ATOM   2280 H  HG13 . VAL   A 1 178 ? -1.590  17.860 46.541 1.00 24.01 ? 158 VAL   A HG13 1 
ATOM   2281 H  HG21 . VAL   A 1 178 ? -1.010  17.547 43.520 1.00 26.93 ? 158 VAL   A HG21 1 
ATOM   2282 H  HG22 . VAL   A 1 178 ? 0.188   17.917 44.497 1.00 26.93 ? 158 VAL   A HG22 1 
ATOM   2283 H  HG23 . VAL   A 1 178 ? 0.264   16.601 43.610 1.00 26.93 ? 158 VAL   A HG23 1 
ATOM   2284 N  N    . ARG   A 1 179 ? -0.482  15.724 48.573 1.00 20.22 ? 159 ARG   A N    1 
ATOM   2285 C  CA   . ARG   A 1 179 ? -1.073  15.107 49.752 1.00 23.29 ? 159 ARG   A CA   1 
ATOM   2286 C  C    . ARG   A 1 179 ? -2.591  15.128 49.628 1.00 19.37 ? 159 ARG   A C    1 
ATOM   2287 O  O    . ARG   A 1 179 ? -3.189  16.181 49.381 1.00 21.44 ? 159 ARG   A O    1 
ATOM   2288 C  CB   . ARG   A 1 179 ? -0.626  15.840 51.011 1.00 21.29 ? 159 ARG   A CB   1 
ATOM   2289 C  CG   . ARG   A 1 179 ? 0.874   15.812 51.242 1.00 27.05 ? 159 ARG   A CG   1 
ATOM   2290 C  CD   . ARG   A 1 179 ? 1.226   16.440 52.576 1.00 30.45 ? 159 ARG   A CD   1 
ATOM   2291 N  NE   . ARG   A 1 179 ? 0.785   17.827 52.655 1.00 25.07 ? 159 ARG   A NE   1 
ATOM   2292 C  CZ   . ARG   A 1 179 ? 1.524   18.870 52.297 1.00 25.77 ? 159 ARG   A CZ   1 
ATOM   2293 N  NH1  . ARG   A 1 179 ? 2.748   18.717 51.818 1.00 31.66 ? 159 ARG   A NH1  1 
ATOM   2294 N  NH2  . ARG   A 1 179 ? 1.023   20.095 52.426 1.00 35.15 ? 159 ARG   A NH2  1 
ATOM   2295 H  H    . ARG   A 1 179 ? -0.095  16.478 48.721 1.00 24.28 ? 159 ARG   A H    1 
ATOM   2296 H  HA   . ARG   A 1 179 ? -0.782  14.184 49.814 1.00 27.96 ? 159 ARG   A HA   1 
ATOM   2297 H  HB2  . ARG   A 1 179 ? -0.898  16.768 50.943 1.00 25.57 ? 159 ARG   A HB2  1 
ATOM   2298 H  HB3  . ARG   A 1 179 ? -1.051  15.428 51.779 1.00 25.57 ? 159 ARG   A HB3  1 
ATOM   2299 H  HG2  . ARG   A 1 179 ? 1.182   14.892 51.246 1.00 32.48 ? 159 ARG   A HG2  1 
ATOM   2300 H  HG3  . ARG   A 1 179 ? 1.317   16.314 50.541 1.00 32.48 ? 159 ARG   A HG3  1 
ATOM   2301 H  HD2  . ARG   A 1 179 ? 0.782   15.945 53.283 1.00 36.56 ? 159 ARG   A HD2  1 
ATOM   2302 H  HD3  . ARG   A 1 179 ? 2.186   16.409 52.704 1.00 36.56 ? 159 ARG   A HD3  1 
ATOM   2303 H  HE   . ARG   A 1 179 ? -0.007  17.980 52.954 1.00 30.11 ? 159 ARG   A HE   1 
ATOM   2304 H  HH11 . ARG   A 1 179 ? 3.085   17.932 51.729 1.00 38.01 ? 159 ARG   A HH11 1 
ATOM   2305 H  HH12 . ARG   A 1 179 ? 3.208   19.408 51.592 1.00 38.01 ? 159 ARG   A HH12 1 
ATOM   2306 H  HH21 . ARG   A 1 179 ? 0.228   20.204 52.737 1.00 42.19 ? 159 ARG   A HH21 1 
ATOM   2307 H  HH22 . ARG   A 1 179 ? 1.493   20.778 52.197 1.00 42.19 ? 159 ARG   A HH22 1 
ATOM   2308 N  N    A ARG   A 1 180 ? -3.214  13.964 49.804 0.47 20.10 ? 160 ARG   A N    1 
ATOM   2309 N  N    B ARG   A 1 180 ? -3.219  13.966 49.799 0.53 20.07 ? 160 ARG   A N    1 
ATOM   2310 C  CA   A ARG   A 1 180 ? -4.644  13.811 49.579 0.47 18.98 ? 160 ARG   A CA   1 
ATOM   2311 C  CA   B ARG   A 1 180 ? -4.653  13.833 49.580 0.53 18.95 ? 160 ARG   A CA   1 
ATOM   2312 C  C    A ARG   A 1 180 ? -5.427  13.524 50.853 0.47 23.85 ? 160 ARG   A C    1 
ATOM   2313 C  C    B ARG   A 1 180 ? -5.432  13.539 50.854 0.53 23.84 ? 160 ARG   A C    1 
ATOM   2314 O  O    A ARG   A 1 180 ? -6.612  13.189 50.775 0.47 24.21 ? 160 ARG   A O    1 
ATOM   2315 O  O    B ARG   A 1 180 ? -6.622  13.218 50.777 0.53 24.20 ? 160 ARG   A O    1 
ATOM   2316 C  CB   A ARG   A 1 180 ? -4.899  12.697 48.560 0.47 26.30 ? 160 ARG   A CB   1 
ATOM   2317 C  CB   B ARG   A 1 180 ? -4.928  12.740 48.545 0.53 26.32 ? 160 ARG   A CB   1 
ATOM   2318 C  CG   A ARG   A 1 180 ? -4.372  13.002 47.171 0.47 30.00 ? 160 ARG   A CG   1 
ATOM   2319 C  CG   B ARG   A 1 180 ? -4.305  13.018 47.193 0.53 30.01 ? 160 ARG   A CG   1 
ATOM   2320 C  CD   A ARG   A 1 180 ? -5.091  12.166 46.131 0.47 31.52 ? 160 ARG   A CD   1 
ATOM   2321 C  CD   B ARG   A 1 180 ? -4.835  12.076 46.133 0.53 31.95 ? 160 ARG   A CD   1 
ATOM   2322 N  NE   A ARG   A 1 180 ? -6.536  12.362 46.190 0.47 31.09 ? 160 ARG   A NE   1 
ATOM   2323 N  NE   B ARG   A 1 180 ? -4.028  12.119 44.920 0.53 30.26 ? 160 ARG   A NE   1 
ATOM   2324 C  CZ   A ARG   A 1 180 ? -7.421  11.621 45.539 0.47 33.10 ? 160 ARG   A CZ   1 
ATOM   2325 C  CZ   B ARG   A 1 180 ? -4.184  11.299 43.890 0.53 26.04 ? 160 ARG   A CZ   1 
ATOM   2326 N  NH1  A ARG   A 1 180 ? -7.044  10.618 44.764 0.47 28.07 ? 160 ARG   A NH1  1 
ATOM   2327 N  NH1  B ARG   A 1 180 ? -5.098  10.343 43.901 0.53 34.66 ? 160 ARG   A NH1  1 
ATOM   2328 N  NH2  A ARG   A 1 180 ? -8.717  11.891 45.671 0.47 36.18 ? 160 ARG   A NH2  1 
ATOM   2329 N  NH2  B ARG   A 1 180 ? -3.405  11.444 42.822 0.53 30.72 ? 160 ARG   A NH2  1 
ATOM   2330 H  H    A ARG   A 1 180 ? -2.823  13.241 50.057 0.47 24.14 ? 160 ARG   A H    1 
ATOM   2331 H  H    B ARG   A 1 180 ? -2.833  13.237 50.043 0.53 24.10 ? 160 ARG   A H    1 
ATOM   2332 H  HA   A ARG   A 1 180 ? -4.991  14.635 49.204 0.47 22.79 ? 160 ARG   A HA   1 
ATOM   2333 H  HA   B ARG   A 1 180 ? -4.992  14.666 49.220 0.53 22.76 ? 160 ARG   A HA   1 
ATOM   2334 H  HB2  A ARG   A 1 180 ? -4.461  11.889 48.869 0.47 31.58 ? 160 ARG   A HB2  1 
ATOM   2335 H  HB2  B ARG   A 1 180 ? -4.567  11.901 48.872 0.53 31.61 ? 160 ARG   A HB2  1 
ATOM   2336 H  HB3  A ARG   A 1 180 ? -5.855  12.548 48.503 0.47 31.58 ? 160 ARG   A HB3  1 
ATOM   2337 H  HB3  B ARG   A 1 180 ? -5.887  12.660 48.420 0.53 31.61 ? 160 ARG   A HB3  1 
ATOM   2338 H  HG2  A ARG   A 1 180 ? -4.520  13.939 46.967 0.47 36.02 ? 160 ARG   A HG2  1 
ATOM   2339 H  HG2  B ARG   A 1 180 ? -4.514  13.926 46.925 0.53 36.03 ? 160 ARG   A HG2  1 
ATOM   2340 H  HG3  A ARG   A 1 180 ? -3.426  12.792 47.132 0.47 36.02 ? 160 ARG   A HG3  1 
ATOM   2341 H  HG3  B ARG   A 1 180 ? -3.344  12.898 47.253 0.53 36.03 ? 160 ARG   A HG3  1 
ATOM   2342 H  HD2  A ARG   A 1 180 ? -4.785  12.423 45.247 0.47 37.84 ? 160 ARG   A HD2  1 
ATOM   2343 H  HD2  B ARG   A 1 180 ? -4.819  11.169 46.476 0.53 38.35 ? 160 ARG   A HD2  1 
ATOM   2344 H  HD3  A ARG   A 1 180 ? -4.905  11.228 46.291 0.47 37.84 ? 160 ARG   A HD3  1 
ATOM   2345 H  HD3  B ARG   A 1 180 ? -5.742  12.332 45.903 0.53 38.35 ? 160 ARG   A HD3  1 
ATOM   2346 H  HE   A ARG   A 1 180 ? -6.829  13.043 46.626 0.47 37.33 ? 160 ARG   A HE   1 
ATOM   2347 H  HE   B ARG   A 1 180 ? -3.436  12.740 44.853 0.53 36.33 ? 160 ARG   A HE   1 
ATOM   2348 H  HH11 A ARG   A 1 180 ? -6.209  10.433 44.671 0.47 33.70 ? 160 ARG   A HH11 1 
ATOM   2349 H  HH11 B ARG   A 1 180 ? -5.608  10.240 44.585 0.53 41.61 ? 160 ARG   A HH11 1 
ATOM   2350 H  HH12 A ARG   A 1 180 ? -7.635  10.150 44.351 0.47 33.70 ? 160 ARG   A HH12 1 
ATOM   2351 H  HH12 B ARG   A 1 180 ? -5.182  9.822  43.222 0.53 41.61 ? 160 ARG   A HH12 1 
ATOM   2352 H  HH21 A ARG   A 1 180 ? -8.972  12.541 46.173 0.47 43.43 ? 160 ARG   A HH21 1 
ATOM   2353 H  HH21 B ARG   A 1 180 ? -2.808  12.063 42.806 0.53 36.89 ? 160 ARG   A HH21 1 
ATOM   2354 H  HH22 A ARG   A 1 180 ? -9.300  11.416 45.253 0.47 43.43 ? 160 ARG   A HH22 1 
ATOM   2355 H  HH22 B ARG   A 1 180 ? -3.496  10.917 42.148 0.53 36.89 ? 160 ARG   A HH22 1 
ATOM   2356 N  N    . ASP   A 1 181 ? -4.800  13.649 52.023 1.00 24.34 ? 161 ASP   A N    1 
ATOM   2357 C  CA   . ASP   A 1 181 ? -5.505  13.362 53.269 1.00 32.03 ? 161 ASP   A CA   1 
ATOM   2358 C  C    . ASP   A 1 181 ? -6.747  14.225 53.418 1.00 31.10 ? 161 ASP   A C    1 
ATOM   2359 O  O    . ASP   A 1 181 ? -7.805  13.741 53.837 1.00 31.90 ? 161 ASP   A O    1 
ATOM   2360 C  CB   . ASP   A 1 181 ? -4.562  13.585 54.445 1.00 29.22 ? 161 ASP   A CB   1 
ATOM   2361 C  CG   . ASP   A 1 181 ? -3.280  12.814 54.299 1.00 33.64 ? 161 ASP   A CG   1 
ATOM   2362 O  OD1  . ASP   A 1 181 ? -3.292  11.610 54.625 1.00 42.60 ? 161 ASP   A OD1  1 
ATOM   2363 O  OD2  . ASP   A 1 181 ? -2.281  13.399 53.817 1.00 37.24 ? 161 ASP   A OD2  1 
ATOM   2364 H  H    A ASP   A 1 181 ? -3.982  13.897 52.120 0.47 29.22 ? 161 ASP   A H    1 
ATOM   2365 H  H    B ASP   A 1 181 ? -3.979  13.886 52.119 0.53 29.22 ? 161 ASP   A H    1 
ATOM   2366 H  HA   . ASP   A 1 181 ? -5.780  12.432 53.273 1.00 38.45 ? 161 ASP   A HA   1 
ATOM   2367 H  HB2  . ASP   A 1 181 ? -4.342  14.528 54.502 1.00 35.08 ? 161 ASP   A HB2  1 
ATOM   2368 H  HB3  . ASP   A 1 181 ? -4.998  13.294 55.261 1.00 35.08 ? 161 ASP   A HB3  1 
ATOM   2369 N  N    . GLY   A 1 182 ? -6.638  15.502 53.082 1.00 21.51 ? 162 GLY   A N    1 
ATOM   2370 C  CA   . GLY   A 1 182 ? -7.733  16.424 53.234 1.00 25.47 ? 162 GLY   A CA   1 
ATOM   2371 C  C    . GLY   A 1 182 ? -8.724  16.420 52.107 1.00 25.54 ? 162 GLY   A C    1 
ATOM   2372 O  O    . GLY   A 1 182 ? -9.731  17.127 52.180 1.00 24.22 ? 162 GLY   A O    1 
ATOM   2373 H  H    . GLY   A 1 182 ? -5.925  15.858 52.759 1.00 25.83 ? 162 GLY   A H    1 
ATOM   2374 H  HA2  . GLY   A 1 182 ? -8.210  16.214 54.052 1.00 30.58 ? 162 GLY   A HA2  1 
ATOM   2375 H  HA3  . GLY   A 1 182 ? -7.378  17.323 53.317 1.00 30.58 ? 162 GLY   A HA3  1 
ATOM   2376 N  N    . LEU   A 1 183 ? -8.469  15.642 51.071 1.00 25.34 ? 163 LEU   A N    1 
ATOM   2377 C  CA   . LEU   A 1 183 ? -9.299  15.560 49.881 1.00 23.65 ? 163 LEU   A CA   1 
ATOM   2378 C  C    . LEU   A 1 183 ? -10.212 14.348 49.945 1.00 29.70 ? 163 LEU   A C    1 
ATOM   2379 O  O    . LEU   A 1 183 ? -9.931  13.374 50.651 1.00 24.47 ? 163 LEU   A O    1 
ATOM   2380 C  CB   . LEU   A 1 183 ? -8.417  15.480 48.636 1.00 26.60 ? 163 LEU   A CB   1 
ATOM   2381 C  CG   . LEU   A 1 183 ? -7.549  16.709 48.356 1.00 25.41 ? 163 LEU   A CG   1 
ATOM   2382 C  CD1  . LEU   A 1 183 ? -6.464  16.394 47.337 1.00 28.64 ? 163 LEU   A CD1  1 
ATOM   2383 C  CD2  . LEU   A 1 183 ? -8.412  17.870 47.880 1.00 33.61 ? 163 LEU   A CD2  1 
ATOM   2384 H  H    . LEU   A 1 183 ? -7.784  15.124 51.031 1.00 30.42 ? 163 LEU   A H    1 
ATOM   2385 H  HA   . LEU   A 1 183 ? -9.839  16.363 49.826 1.00 28.40 ? 163 LEU   A HA   1 
ATOM   2386 H  HB2  . LEU   A 1 183 ? -7.820  14.723 48.740 1.00 31.94 ? 163 LEU   A HB2  1 
ATOM   2387 H  HB3  . LEU   A 1 183 ? -8.979  15.339 47.860 1.00 31.94 ? 163 LEU   A HB3  1 
ATOM   2388 H  HG   . LEU   A 1 183 ? -7.114  16.980 49.179 1.00 30.51 ? 163 LEU   A HG   1 
ATOM   2389 H  HD11 . LEU   A 1 183 ? -5.737  17.027 47.444 1.00 34.38 ? 163 LEU   A HD11 1 
ATOM   2390 H  HD12 . LEU   A 1 183 ? -6.142  15.492 47.483 1.00 34.38 ? 163 LEU   A HD12 1 
ATOM   2391 H  HD13 . LEU   A 1 183 ? -6.840  16.467 46.446 1.00 34.38 ? 163 LEU   A HD13 1 
ATOM   2392 H  HD21 . LEU   A 1 183 ? -7.838  18.621 47.662 1.00 40.35 ? 163 LEU   A HD21 1 
ATOM   2393 H  HD22 . LEU   A 1 183 ? -8.907  17.593 47.093 1.00 40.35 ? 163 LEU   A HD22 1 
ATOM   2394 H  HD23 . LEU   A 1 183 ? -9.027  18.118 48.588 1.00 40.35 ? 163 LEU   A HD23 1 
ATOM   2395 N  N    A PRO   A 1 184 ? -11.330 14.376 49.222 0.49 31.49 ? 164 PRO   A N    1 
ATOM   2396 N  N    B PRO   A 1 184 ? -11.330 14.376 49.222 0.51 31.35 ? 164 PRO   A N    1 
ATOM   2397 C  CA   A PRO   A 1 184 ? -12.245 13.227 49.250 0.49 35.12 ? 164 PRO   A CA   1 
ATOM   2398 C  CA   B PRO   A 1 184 ? -12.245 13.227 49.250 0.51 35.05 ? 164 PRO   A CA   1 
ATOM   2399 C  C    A PRO   A 1 184 ? -11.612 12.000 48.613 0.49 40.26 ? 164 PRO   A C    1 
ATOM   2400 C  C    B PRO   A 1 184 ? -11.612 12.000 48.614 0.51 40.26 ? 164 PRO   A C    1 
ATOM   2401 O  O    A PRO   A 1 184 ? -10.896 12.092 47.614 0.49 44.68 ? 164 PRO   A O    1 
ATOM   2402 O  O    B PRO   A 1 184 ? -10.895 12.092 47.615 0.51 44.69 ? 164 PRO   A O    1 
ATOM   2403 C  CB   A PRO   A 1 184 ? -13.461 13.717 48.452 0.49 36.61 ? 164 PRO   A CB   1 
ATOM   2404 C  CB   B PRO   A 1 184 ? -13.462 13.717 48.453 0.51 36.61 ? 164 PRO   A CB   1 
ATOM   2405 C  CG   A PRO   A 1 184 ? -12.922 14.803 47.565 0.49 41.81 ? 164 PRO   A CG   1 
ATOM   2406 C  CG   B PRO   A 1 184 ? -12.922 14.803 47.566 0.51 41.82 ? 164 PRO   A CG   1 
ATOM   2407 C  CD   A PRO   A 1 184 ? -11.828 15.470 48.364 0.49 35.33 ? 164 PRO   A CD   1 
ATOM   2408 C  CD   B PRO   A 1 184 ? -11.829 15.470 48.365 0.51 35.33 ? 164 PRO   A CD   1 
ATOM   2409 H  HA   A PRO   A 1 184 ? -12.512 13.023 50.160 0.49 42.17 ? 164 PRO   A HA   1 
ATOM   2410 H  HA   B PRO   A 1 184 ? -12.511 13.023 50.160 0.51 42.08 ? 164 PRO   A HA   1 
ATOM   2411 H  HB2  A PRO   A 1 184 ? -13.822 12.988 47.923 0.49 43.95 ? 164 PRO   A HB2  1 
ATOM   2412 H  HB2  B PRO   A 1 184 ? -13.824 12.988 47.925 0.51 43.95 ? 164 PRO   A HB2  1 
ATOM   2413 H  HB3  A PRO   A 1 184 ? -14.131 14.069 49.058 0.49 43.95 ? 164 PRO   A HB3  1 
ATOM   2414 H  HB3  B PRO   A 1 184 ? -14.132 14.069 49.060 0.51 43.95 ? 164 PRO   A HB3  1 
ATOM   2415 H  HG2  A PRO   A 1 184 ? -12.563 14.412 46.753 0.49 50.19 ? 164 PRO   A HG2  1 
ATOM   2416 H  HG2  B PRO   A 1 184 ? -12.562 14.412 46.754 0.51 50.20 ? 164 PRO   A HG2  1 
ATOM   2417 H  HG3  A PRO   A 1 184 ? -13.628 15.435 47.358 0.49 50.19 ? 164 PRO   A HG3  1 
ATOM   2418 H  HG3  B PRO   A 1 184 ? -13.628 15.435 47.358 0.51 50.20 ? 164 PRO   A HG3  1 
ATOM   2419 H  HD2  A PRO   A 1 184 ? -11.128 15.790 47.775 0.49 42.42 ? 164 PRO   A HD2  1 
ATOM   2420 H  HD2  B PRO   A 1 184 ? -11.130 15.791 47.776 0.51 42.42 ? 164 PRO   A HD2  1 
ATOM   2421 H  HD3  A PRO   A 1 184 ? -12.193 16.186 48.906 0.49 42.42 ? 164 PRO   A HD3  1 
ATOM   2422 H  HD3  B PRO   A 1 184 ? -12.195 16.186 48.908 0.51 42.42 ? 164 PRO   A HD3  1 
ATOM   2423 N  N    . SER   A 1 185 ? -11.880 10.842 49.208 0.64 44.49 ? 165 SER   A N    1 
ATOM   2424 C  CA   . SER   A 1 185 ? -11.362 9.579  48.690 0.96 43.49 ? 165 SER   A CA   1 
ATOM   2425 C  C    . SER   A 1 185 ? -12.310 8.438  49.052 0.89 54.93 ? 165 SER   A C    1 
ATOM   2426 O  O    . SER   A 1 185 ? -13.459 8.672  49.430 0.90 53.23 ? 165 SER   A O    1 
ATOM   2427 C  CB   . SER   A 1 185 ? -9.963  9.297  49.234 1.00 58.19 ? 165 SER   A CB   1 
ATOM   2428 H  H    A SER   A 1 185 ? -12.361 10.760 49.916 0.49 53.40 ? 165 SER   A H    1 
ATOM   2429 H  H    B SER   A 1 185 ? -12.362 10.760 49.916 0.51 53.40 ? 165 SER   A H    1 
ATOM   2430 H  HA   . SER   A 1 185 ? -11.306 9.629  47.723 0.95 52.21 ? 165 SER   A HA   1 
ATOM   2431 N  N    . GLU   B 1 32  ? -29.622 8.203  8.235  1.00 43.88 ? 12  GLU   B N    1 
ATOM   2432 C  CA   . GLU   B 1 32  ? -28.510 8.105  9.172  1.00 49.55 ? 12  GLU   B CA   1 
ATOM   2433 C  C    . GLU   B 1 32  ? -27.796 9.445  9.304  1.00 45.85 ? 12  GLU   B C    1 
ATOM   2434 O  O    . GLU   B 1 32  ? -27.531 9.913  10.413 1.00 47.38 ? 12  GLU   B O    1 
ATOM   2435 C  CB   . GLU   B 1 32  ? -27.523 7.027  8.724  1.00 52.36 ? 12  GLU   B CB   1 
ATOM   2436 H  HA   . GLU   B 1 32  ? -28.851 7.858  10.046 1.00 59.48 ? 12  GLU   B HA   1 
ATOM   2437 N  N    . ASN   B 1 33  ? -27.480 10.056 8.160  0.87 47.43 ? 13  ASN   B N    1 
ATOM   2438 C  CA   . ASN   B 1 33  ? -26.815 11.354 8.180  0.87 56.81 ? 13  ASN   B CA   1 
ATOM   2439 C  C    . ASN   B 1 33  ? -27.615 12.366 8.989  0.87 48.09 ? 13  ASN   B C    1 
ATOM   2440 O  O    . ASN   B 1 33  ? -27.048 13.135 9.773  0.87 43.57 ? 13  ASN   B O    1 
ATOM   2441 C  CB   . ASN   B 1 33  ? -26.604 11.858 6.753  0.87 42.03 ? 13  ASN   B CB   1 
ATOM   2442 H  H    . ASN   B 1 33  ? -27.638 9.745  7.374  0.87 56.93 ? 13  ASN   B H    1 
ATOM   2443 H  HA   . ASN   B 1 33  ? -25.944 11.257 8.596  0.87 68.20 ? 13  ASN   B HA   1 
ATOM   2444 N  N    . ARG   B 1 34  ? -28.939 12.377 8.816  1.00 43.78 ? 14  ARG   B N    1 
ATOM   2445 C  CA   . ARG   B 1 34  ? -29.772 13.320 9.554  1.00 42.69 ? 14  ARG   B CA   1 
ATOM   2446 C  C    . ARG   B 1 34  ? -29.709 13.061 11.055 1.00 34.93 ? 14  ARG   B C    1 
ATOM   2447 O  O    . ARG   B 1 34  ? -29.608 14.003 11.850 1.00 38.32 ? 14  ARG   B O    1 
ATOM   2448 C  CB   . ARG   B 1 34  ? -31.217 13.239 9.061  1.00 55.45 ? 14  ARG   B CB   1 
ATOM   2449 H  H    . ARG   B 1 34  ? -29.371 11.856 8.285  1.00 52.56 ? 14  ARG   B H    1 
ATOM   2450 H  HA   . ARG   B 1 34  ? -29.450 14.220 9.391  1.00 51.24 ? 14  ARG   B HA   1 
ATOM   2451 N  N    . ALA   B 1 35  ? -29.787 11.792 11.463 0.88 26.55 ? 15  ALA   B N    1 
ATOM   2452 C  CA   . ALA   B 1 35  ? -29.669 11.464 12.880 0.88 30.51 ? 15  ALA   B CA   1 
ATOM   2453 C  C    . ALA   B 1 35  ? -28.285 11.805 13.417 0.88 28.95 ? 15  ALA   B C    1 
ATOM   2454 O  O    . ALA   B 1 35  ? -28.146 12.174 14.590 0.88 25.18 ? 15  ALA   B O    1 
ATOM   2455 C  CB   . ALA   B 1 35  ? -29.968 9.981  13.104 0.88 35.70 ? 15  ALA   B CB   1 
ATOM   2456 H  H    . ALA   B 1 35  ? -29.906 11.115 10.947 0.88 31.88 ? 15  ALA   B H    1 
ATOM   2457 H  HA   . ALA   B 1 35  ? -30.312 11.984 13.379 0.88 36.64 ? 15  ALA   B HA   1 
ATOM   2458 H  HB1  . ALA   B 1 35  ? -29.885 9.782  14.050 0.88 42.86 ? 15  ALA   B HB1  1 
ATOM   2459 H  HB2  . ALA   B 1 35  ? -30.871 9.793  12.804 0.88 42.86 ? 15  ALA   B HB2  1 
ATOM   2460 H  HB3  . ALA   B 1 35  ? -29.333 9.451  12.597 0.88 42.86 ? 15  ALA   B HB3  1 
ATOM   2461 N  N    . GLN   B 1 36  ? -27.251 11.678 12.583 1.00 30.62 ? 16  GLN   B N    1 
ATOM   2462 C  CA   . GLN   B 1 36  ? -25.908 12.021 13.035 1.00 24.76 ? 16  GLN   B CA   1 
ATOM   2463 C  C    . GLN   B 1 36  ? -25.730 13.528 13.145 1.00 25.92 ? 16  GLN   B C    1 
ATOM   2464 O  O    . GLN   B 1 36  ? -25.174 14.023 14.133 1.00 28.77 ? 16  GLN   B O    1 
ATOM   2465 C  CB   . GLN   B 1 36  ? -24.871 11.430 12.087 1.00 32.44 ? 16  GLN   B CB   1 
ATOM   2466 C  CG   . GLN   B 1 36  ? -24.705 9.941  12.248 1.00 43.75 ? 16  GLN   B CG   1 
ATOM   2467 H  H    . GLN   B 1 36  ? -27.300 11.402 11.770 1.00 36.76 ? 16  GLN   B H    1 
ATOM   2468 H  HA   . GLN   B 1 36  ? -25.763 11.637 13.914 1.00 29.73 ? 16  GLN   B HA   1 
ATOM   2469 H  HB2  . GLN   B 1 36  ? -25.145 11.603 11.173 1.00 38.95 ? 16  GLN   B HB2  1 
ATOM   2470 H  HB3  . GLN   B 1 36  ? -24.012 11.847 12.260 1.00 38.95 ? 16  GLN   B HB3  1 
ATOM   2471 N  N    . VAL   B 1 37  ? -26.186 14.272 12.137 1.00 22.96 ? 17  VAL   B N    1 
ATOM   2472 C  CA   . VAL   B 1 37  ? -26.092 15.724 12.201 1.00 23.22 ? 17  VAL   B CA   1 
ATOM   2473 C  C    . VAL   B 1 37  ? -26.863 16.245 13.406 1.00 27.09 ? 17  VAL   B C    1 
ATOM   2474 O  O    . VAL   B 1 37  ? -26.399 17.146 14.118 1.00 30.67 ? 17  VAL   B O    1 
ATOM   2475 C  CB   . VAL   B 1 37  ? -26.605 16.355 10.893 1.00 31.74 ? 17  VAL   B CB   1 
ATOM   2476 C  CG1  . VAL   B 1 37  ? -26.669 17.870 11.039 1.00 39.95 ? 17  VAL   B CG1  1 
ATOM   2477 C  CG2  . VAL   B 1 37  ? -25.720 15.955 9.716  1.00 37.46 ? 17  VAL   B CG2  1 
ATOM   2478 H  H    . VAL   B 1 37  ? -26.547 13.965 11.419 1.00 27.56 ? 17  VAL   B H    1 
ATOM   2479 H  HA   . VAL   B 1 37  ? -25.161 15.975 12.310 1.00 27.89 ? 17  VAL   B HA   1 
ATOM   2480 H  HB   . VAL   B 1 37  ? -27.503 16.032 10.717 1.00 38.10 ? 17  VAL   B HB   1 
ATOM   2481 H  HG11 . VAL   B 1 37  ? -26.717 18.268 10.156 1.00 47.96 ? 17  VAL   B HG11 1 
ATOM   2482 H  HG12 . VAL   B 1 37  ? -27.458 18.108 11.551 1.00 47.96 ? 17  VAL   B HG12 1 
ATOM   2483 H  HG13 . VAL   B 1 37  ? -25.870 18.177 11.495 1.00 47.96 ? 17  VAL   B HG13 1 
ATOM   2484 H  HG21 . VAL   B 1 37  ? -26.169 16.193 8.890  1.00 44.97 ? 17  VAL   B HG21 1 
ATOM   2485 H  HG22 . VAL   B 1 37  ? -24.876 16.429 9.782  1.00 44.97 ? 17  VAL   B HG22 1 
ATOM   2486 H  HG23 . VAL   B 1 37  ? -25.564 14.999 9.743  1.00 44.97 ? 17  VAL   B HG23 1 
ATOM   2487 N  N    . ALA   B 1 38  ? -28.052 15.688 13.652 1.00 23.97 ? 18  ALA   B N    1 
ATOM   2488 C  CA   . ALA   B 1 38  ? -28.857 16.118 14.791 1.00 27.87 ? 18  ALA   B CA   1 
ATOM   2489 C  C    . ALA   B 1 38  ? -28.133 15.863 16.106 1.00 25.92 ? 18  ALA   B C    1 
ATOM   2490 O  O    . ALA   B 1 38  ? -28.114 16.722 16.995 1.00 23.06 ? 18  ALA   B O    1 
ATOM   2491 C  CB   . ALA   B 1 38  ? -30.205 15.398 14.780 1.00 28.84 ? 18  ALA   B CB   1 
ATOM   2492 H  H    . ALA   B 1 38  ? -28.409 15.066 13.178 1.00 28.79 ? 18  ALA   B H    1 
ATOM   2493 H  HA   . ALA   B 1 38  ? -29.024 17.071 14.719 1.00 33.46 ? 18  ALA   B HA   1 
ATOM   2494 H  HB1  . ALA   B 1 38  ? -30.727 15.694 15.542 1.00 34.62 ? 18  ALA   B HB1  1 
ATOM   2495 H  HB2  . ALA   B 1 38  ? -30.670 15.612 13.956 1.00 34.62 ? 18  ALA   B HB2  1 
ATOM   2496 H  HB3  . ALA   B 1 38  ? -30.052 14.442 14.835 1.00 34.62 ? 18  ALA   B HB3  1 
ATOM   2497 N  N    . ALA   B 1 39  ? -27.559 14.667 16.256 1.00 19.87 ? 19  ALA   B N    1 
ATOM   2498 C  CA   . ALA   B 1 39  ? -26.792 14.348 17.456 1.00 24.19 ? 19  ALA   B CA   1 
ATOM   2499 C  C    . ALA   B 1 39  ? -25.652 15.338 17.658 1.00 22.78 ? 19  ALA   B C    1 
ATOM   2500 O  O    . ALA   B 1 39  ? -25.434 15.838 18.768 1.00 19.57 ? 19  ALA   B O    1 
ATOM   2501 C  CB   . ALA   B 1 39  ? -26.243 12.922 17.366 1.00 25.42 ? 19  ALA   B CB   1 
ATOM   2502 H  H    . ALA   B 1 39  ? -27.600 14.029 15.681 1.00 23.86 ? 19  ALA   B H    1 
ATOM   2503 H  HA   . ALA   B 1 39  ? -27.376 14.398 18.229 1.00 29.04 ? 19  ALA   B HA   1 
ATOM   2504 H  HB1  . ALA   B 1 39  ? -25.737 12.728 18.170 1.00 30.52 ? 19  ALA   B HB1  1 
ATOM   2505 H  HB2  . ALA   B 1 39  ? -26.985 12.303 17.284 1.00 30.52 ? 19  ALA   B HB2  1 
ATOM   2506 H  HB3  . ALA   B 1 39  ? -25.668 12.854 16.588 1.00 30.52 ? 19  ALA   B HB3  1 
ATOM   2507 N  N    . ARG   B 1 40  ? -24.903 15.628 16.593 1.00 20.07 ? 20  ARG   B N    1 
ATOM   2508 C  CA   . ARG   B 1 40  ? -23.714 16.455 16.757 1.00 20.31 ? 20  ARG   B CA   1 
ATOM   2509 C  C    . ARG   B 1 40  ? -24.091 17.885 17.136 1.00 20.16 ? 20  ARG   B C    1 
ATOM   2510 O  O    . ARG   B 1 40  ? -23.479 18.473 18.036 1.00 19.78 ? 20  ARG   B O    1 
ATOM   2511 C  CB   . ARG   B 1 40  ? -22.873 16.419 15.483 1.00 19.53 ? 20  ARG   B CB   1 
ATOM   2512 C  CG   . ARG   B 1 40  ? -21.552 17.150 15.607 1.00 23.49 ? 20  ARG   B CG   1 
ATOM   2513 C  CD   . ARG   B 1 40  ? -20.777 17.132 14.296 1.00 23.24 ? 20  ARG   B CD   1 
ATOM   2514 N  NE   . ARG   B 1 40  ? -20.164 15.834 14.034 1.00 21.33 ? 20  ARG   B NE   1 
ATOM   2515 C  CZ   . ARG   B 1 40  ? -20.617 14.942 13.162 1.00 24.61 ? 20  ARG   B CZ   1 
ATOM   2516 N  NH1  . ARG   B 1 40  ? -21.680 15.183 12.413 1.00 27.95 ? 20  ARG   B NH1  1 
ATOM   2517 N  NH2  . ARG   B 1 40  ? -19.980 13.782 13.034 1.00 19.52 ? 20  ARG   B NH2  1 
ATOM   2518 H  H    . ARG   B 1 40  ? -25.057 15.366 15.789 1.00 24.10 ? 20  ARG   B H    1 
ATOM   2519 H  HA   . ARG   B 1 40  ? -23.177 16.090 17.477 1.00 24.39 ? 20  ARG   B HA   1 
ATOM   2520 H  HB2  . ARG   B 1 40  ? -22.681 15.495 15.260 1.00 23.45 ? 20  ARG   B HB2  1 
ATOM   2521 H  HB3  . ARG   B 1 40  ? -23.376 16.833 14.764 1.00 23.45 ? 20  ARG   B HB3  1 
ATOM   2522 H  HG2  . ARG   B 1 40  ? -21.717 18.075 15.847 1.00 28.21 ? 20  ARG   B HG2  1 
ATOM   2523 H  HG3  . ARG   B 1 40  ? -21.010 16.718 16.286 1.00 28.21 ? 20  ARG   B HG3  1 
ATOM   2524 H  HD2  . ARG   B 1 40  ? -21.376 17.357 13.570 1.00 27.90 ? 20  ARG   B HD2  1 
ATOM   2525 H  HD3  . ARG   B 1 40  ? -20.067 17.790 14.345 1.00 27.90 ? 20  ARG   B HD3  1 
ATOM   2526 H  HE   . ARG   B 1 40  ? -19.456 15.632 14.478 1.00 25.61 ? 20  ARG   B HE   1 
ATOM   2527 H  HH11 . ARG   B 1 40  ? -22.105 15.926 12.482 1.00 33.56 ? 20  ARG   B HH11 1 
ATOM   2528 H  HH12 . ARG   B 1 40  ? -21.951 14.588 11.855 1.00 33.56 ? 20  ARG   B HH12 1 
ATOM   2529 H  HH21 . ARG   B 1 40  ? -19.286 13.617 13.515 1.00 23.44 ? 20  ARG   B HH21 1 
ATOM   2530 H  HH22 . ARG   B 1 40  ? -20.262 13.197 12.470 1.00 23.44 ? 20  ARG   B HH22 1 
ATOM   2531 N  N    . GLN   B 1 41  ? -25.114 18.448 16.487 1.00 20.22 ? 21  GLN   B N    1 
ATOM   2532 C  CA   . GLN   B 1 41  ? -25.549 19.800 16.831 1.00 20.40 ? 21  GLN   B CA   1 
ATOM   2533 C  C    . GLN   B 1 41  ? -26.000 19.886 18.286 1.00 19.52 ? 21  GLN   B C    1 
ATOM   2534 O  O    . GLN   B 1 41  ? -25.668 20.843 18.996 1.00 20.54 ? 21  GLN   B O    1 
ATOM   2535 C  CB   . GLN   B 1 41  ? -26.678 20.238 15.900 1.00 24.10 ? 21  GLN   B CB   1 
ATOM   2536 H  H    . GLN   B 1 41  ? -25.564 18.075 15.856 1.00 24.28 ? 21  GLN   B H    1 
ATOM   2537 H  HA   . GLN   B 1 41  ? -24.806 20.412 16.710 1.00 24.50 ? 21  GLN   B HA   1 
ATOM   2538 N  N    . HIS   B 1 42  ? -26.773 18.906 18.745 1.00 19.64 ? 22  HIS   B N    1 
ATOM   2539 C  CA   . HIS   B 1 42  ? -27.212 18.928 20.133 1.00 18.98 ? 22  HIS   B CA   1 
ATOM   2540 C  C    . HIS   B 1 42  ? -26.039 18.734 21.087 1.00 17.35 ? 22  HIS   B C    1 
ATOM   2541 O  O    . HIS   B 1 42  ? -25.896 19.465 22.074 1.00 18.03 ? 22  HIS   B O    1 
ATOM   2542 C  CB   . HIS   B 1 42  ? -28.254 17.846 20.380 1.00 22.75 ? 22  HIS   B CB   1 
ATOM   2543 C  CG   . HIS   B 1 42  ? -28.476 17.579 21.829 1.00 21.71 ? 22  HIS   B CG   1 
ATOM   2544 N  ND1  . HIS   B 1 42  ? -29.311 18.355 22.602 1.00 22.92 ? 22  HIS   B ND1  1 
ATOM   2545 C  CD2  . HIS   B 1 42  ? -27.932 16.662 22.662 1.00 21.81 ? 22  HIS   B CD2  1 
ATOM   2546 C  CE1  . HIS   B 1 42  ? -29.291 17.910 23.843 1.00 19.03 ? 22  HIS   B CE1  1 
ATOM   2547 N  NE2  . HIS   B 1 42  ? -28.465 16.882 23.907 1.00 19.67 ? 22  HIS   B NE2  1 
ATOM   2548 H  H    . HIS   B 1 42  ? -27.050 18.234 18.286 1.00 23.58 ? 22  HIS   B H    1 
ATOM   2549 H  HA   . HIS   B 1 42  ? -27.618 19.788 20.324 1.00 22.79 ? 22  HIS   B HA   1 
ATOM   2550 H  HB2  . HIS   B 1 42  ? -29.098 18.127 19.994 1.00 27.31 ? 22  HIS   B HB2  1 
ATOM   2551 H  HB3  . HIS   B 1 42  ? -27.957 17.021 19.965 1.00 27.31 ? 22  HIS   B HB3  1 
ATOM   2552 H  HD2  . HIS   B 1 42  ? -27.324 15.998 22.431 1.00 26.19 ? 22  HIS   B HD2  1 
ATOM   2553 H  HE1  . HIS   B 1 42  ? -29.780 18.259 24.553 1.00 22.86 ? 22  HIS   B HE1  1 
ATOM   2554 H  HE2  . HIS   B 1 42  ? -28.289 16.426 24.614 1.00 23.62 ? 22  HIS   B HE2  1 
ATOM   2555 N  N    . ASN   B 1 43  ? -25.197 17.736 20.816 1.00 18.09 ? 23  ASN   B N    1 
ATOM   2556 C  CA   . ASN   B 1 43  ? -24.070 17.465 21.700 1.00 17.32 ? 23  ASN   B CA   1 
ATOM   2557 C  C    . ASN   B 1 43  ? -23.140 18.669 21.790 1.00 20.48 ? 23  ASN   B C    1 
ATOM   2558 O  O    . ASN   B 1 43  ? -22.583 18.952 22.855 1.00 16.71 ? 23  ASN   B O    1 
ATOM   2559 C  CB   . ASN   B 1 43  ? -23.319 16.223 21.218 1.00 17.96 ? 23  ASN   B CB   1 
ATOM   2560 C  CG   . ASN   B 1 43  ? -24.160 14.957 21.316 1.00 17.99 ? 23  ASN   B CG   1 
ATOM   2561 O  OD1  . ASN   B 1 43  ? -25.159 14.916 22.030 1.00 19.36 ? 23  ASN   B OD1  1 
ATOM   2562 N  ND2  . ASN   B 1 43  ? -23.748 13.915 20.604 1.00 17.84 ? 23  ASN   B ND2  1 
ATOM   2563 H  H    . ASN   B 1 43  ? -25.256 17.211 20.138 1.00 21.73 ? 23  ASN   B H    1 
ATOM   2564 H  HA   . ASN   B 1 43  ? -24.407 17.282 22.591 1.00 20.81 ? 23  ASN   B HA   1 
ATOM   2565 H  HB2  . ASN   B 1 43  ? -23.068 16.346 20.289 1.00 21.57 ? 23  ASN   B HB2  1 
ATOM   2566 H  HB3  . ASN   B 1 43  ? -22.527 16.100 21.764 1.00 21.57 ? 23  ASN   B HB3  1 
ATOM   2567 H  HD21 . ASN   B 1 43  ? -24.189 13.177 20.627 1.00 21.43 ? 23  ASN   B HD21 1 
ATOM   2568 H  HD22 . ASN   B 1 43  ? -23.043 13.979 20.116 1.00 21.43 ? 23  ASN   B HD22 1 
ATOM   2569 N  N    . ARG   B 1 44  ? -22.972 19.404 20.689 1.00 17.95 ? 24  ARG   B N    1 
ATOM   2570 C  CA   . ARG   B 1 44  ? -22.095 20.569 20.735 1.00 16.40 ? 24  ARG   B CA   1 
ATOM   2571 C  C    . ARG   B 1 44  ? -22.621 21.608 21.721 1.00 20.81 ? 24  ARG   B C    1 
ATOM   2572 O  O    . ARG   B 1 44  ? -21.841 22.261 22.425 1.00 18.48 ? 24  ARG   B O    1 
ATOM   2573 C  CB   . ARG   B 1 44  ? -21.947 21.180 19.347 1.00 19.01 ? 24  ARG   B CB   1 
ATOM   2574 C  CG   . ARG   B 1 44  ? -21.311 22.543 19.398 1.00 24.77 ? 24  ARG   B CG   1 
ATOM   2575 C  CD   . ARG   B 1 44  ? -20.581 22.878 18.129 1.00 44.04 ? 24  ARG   B CD   1 
ATOM   2576 N  NE   . ARG   B 1 44  ? -19.818 24.105 18.312 1.00 44.12 ? 24  ARG   B NE   1 
ATOM   2577 C  CZ   . ARG   B 1 44  ? -18.732 24.420 17.624 1.00 27.52 ? 24  ARG   B CZ   1 
ATOM   2578 N  NH1  . ARG   B 1 44  ? -18.232 23.602 16.712 1.00 43.60 ? 24  ARG   B NH1  1 
ATOM   2579 N  NH2  . ARG   B 1 44  ? -18.129 25.582 17.861 1.00 50.16 ? 24  ARG   B NH2  1 
ATOM   2580 H  H    . ARG   B 1 44  ? -23.342 19.254 19.927 1.00 21.56 ? 24  ARG   B H    1 
ATOM   2581 H  HA   . ARG   B 1 44  ? -21.216 20.290 21.035 1.00 19.70 ? 24  ARG   B HA   1 
ATOM   2582 H  HB2  . ARG   B 1 44  ? -21.388 20.604 18.803 1.00 22.83 ? 24  ARG   B HB2  1 
ATOM   2583 H  HB3  . ARG   B 1 44  ? -22.825 21.271 18.944 1.00 22.83 ? 24  ARG   B HB3  1 
ATOM   2584 H  HG2  . ARG   B 1 44  ? -22.000 23.212 19.535 1.00 29.75 ? 24  ARG   B HG2  1 
ATOM   2585 H  HG3  . ARG   B 1 44  ? -20.670 22.570 20.126 1.00 29.75 ? 24  ARG   B HG3  1 
ATOM   2586 H  HD2  . ARG   B 1 44  ? -19.969 22.158 17.912 1.00 52.87 ? 24  ARG   B HD2  1 
ATOM   2587 H  HD3  . ARG   B 1 44  ? -21.219 23.013 17.411 1.00 52.87 ? 24  ARG   B HD3  1 
ATOM   2588 H  HE   . ARG   B 1 44  ? -20.091 24.662 18.907 1.00 52.96 ? 24  ARG   B HE   1 
ATOM   2589 H  HH11 . ARG   B 1 44  ? -18.612 22.849 16.549 1.00 52.34 ? 24  ARG   B HH11 1 
ATOM   2590 H  HH12 . ARG   B 1 44  ? -17.525 23.827 16.278 1.00 52.34 ? 24  ARG   B HH12 1 
ATOM   2591 H  HH21 . ARG   B 1 44  ? -18.447 26.118 18.453 1.00 60.21 ? 24  ARG   B HH21 1 
ATOM   2592 H  HH22 . ARG   B 1 44  ? -17.421 25.797 17.422 1.00 60.21 ? 24  ARG   B HH22 1 
ATOM   2593 N  N    . LYS   B 1 45  ? -23.944 21.772 21.787 1.00 18.20 ? 25  LYS   B N    1 
ATOM   2594 C  CA   . LYS   B 1 45  ? -24.525 22.723 22.728 1.00 17.39 ? 25  LYS   B CA   1 
ATOM   2595 C  C    . LYS   B 1 45  ? -24.228 22.322 24.167 1.00 13.82 ? 25  LYS   B C    1 
ATOM   2596 O  O    . LYS   B 1 45  ? -23.972 23.182 25.017 1.00 17.39 ? 25  LYS   B O    1 
ATOM   2597 C  CB   . LYS   B 1 45  ? -26.033 22.830 22.503 1.00 16.28 ? 25  LYS   B CB   1 
ATOM   2598 C  CG   . LYS   B 1 45  ? -26.417 23.548 21.226 1.00 24.16 ? 25  LYS   B CG   1 
ATOM   2599 H  H    . LYS   B 1 45  ? -24.517 21.350 21.304 1.00 21.86 ? 25  LYS   B H    1 
ATOM   2600 H  HA   . LYS   B 1 45  ? -24.136 23.598 22.574 1.00 20.89 ? 25  LYS   B HA   1 
ATOM   2601 H  HB2  . LYS   B 1 45  ? -26.406 21.936 22.463 1.00 19.56 ? 25  LYS   B HB2  1 
ATOM   2602 H  HB3  . LYS   B 1 45  ? -26.425 23.316 23.245 1.00 19.56 ? 25  LYS   B HB3  1 
ATOM   2603 N  N    . ILE   B 1 46  ? -24.243 21.015 24.454 1.00 16.50 ? 26  ILE   B N    1 
ATOM   2604 C  CA   . ILE   B 1 46  ? -23.928 20.536 25.797 1.00 13.61 ? 26  ILE   B CA   1 
ATOM   2605 C  C    . ILE   B 1 46  ? -22.465 20.810 26.132 1.00 16.51 ? 26  ILE   B C    1 
ATOM   2606 O  O    . ILE   B 1 46  ? -22.129 21.196 27.260 1.00 14.62 ? 26  ILE   B O    1 
ATOM   2607 C  CB   . ILE   B 1 46  ? -24.246 19.034 25.915 1.00 12.31 ? 26  ILE   B CB   1 
ATOM   2608 C  CG1  . ILE   B 1 46  ? -25.731 18.751 25.680 1.00 18.28 ? 26  ILE   B CG1  1 
ATOM   2609 C  CG2  . ILE   B 1 46  ? -23.826 18.491 27.285 1.00 17.07 ? 26  ILE   B CG2  1 
ATOM   2610 C  CD1  . ILE   B 1 46  ? -26.655 19.421 26.672 1.00 24.80 ? 26  ILE   B CD1  1 
ATOM   2611 H  H    . ILE   B 1 46  ? -24.431 20.393 23.891 1.00 19.82 ? 26  ILE   B H    1 
ATOM   2612 H  HA   . ILE   B 1 46  ? -24.472 21.015 26.440 1.00 16.35 ? 26  ILE   B HA   1 
ATOM   2613 H  HB   . ILE   B 1 46  ? -23.738 18.564 25.235 1.00 14.79 ? 26  ILE   B HB   1 
ATOM   2614 H  HG12 . ILE   B 1 46  ? -25.972 19.064 24.794 1.00 21.95 ? 26  ILE   B HG12 1 
ATOM   2615 H  HG13 . ILE   B 1 46  ? -25.878 17.794 25.740 1.00 21.95 ? 26  ILE   B HG13 1 
ATOM   2616 H  HG21 . ILE   B 1 46  ? -24.249 17.629 27.424 1.00 20.50 ? 26  ILE   B HG21 1 
ATOM   2617 H  HG22 . ILE   B 1 46  ? -22.861 18.391 27.306 1.00 20.50 ? 26  ILE   B HG22 1 
ATOM   2618 H  HG23 . ILE   B 1 46  ? -24.111 19.113 27.972 1.00 20.50 ? 26  ILE   B HG23 1 
ATOM   2619 H  HD11 . ILE   B 1 46  ? -27.564 19.134 26.494 1.00 29.78 ? 26  ILE   B HD11 1 
ATOM   2620 H  HD12 . ILE   B 1 46  ? -26.400 19.164 27.572 1.00 29.78 ? 26  ILE   B HD12 1 
ATOM   2621 H  HD13 . ILE   B 1 46  ? -26.589 20.383 26.570 1.00 29.78 ? 26  ILE   B HD13 1 
ATOM   2622 N  N    . VAL   B 1 47  ? -21.565 20.598 25.167 1.00 17.40 ? 27  VAL   B N    1 
ATOM   2623 C  CA   . VAL   B 1 47  ? -20.153 20.879 25.407 1.00 14.17 ? 27  VAL   B CA   1 
ATOM   2624 C  C    . VAL   B 1 47  ? -19.960 22.359 25.711 1.00 12.40 ? 27  VAL   B C    1 
ATOM   2625 O  O    . VAL   B 1 47  ? -19.260 22.735 26.658 1.00 14.39 ? 27  VAL   B O    1 
ATOM   2626 C  CB   . VAL   B 1 47  ? -19.300 20.439 24.203 1.00 14.73 ? 27  VAL   B CB   1 
ATOM   2627 C  CG1  . VAL   B 1 47  ? -17.856 20.872 24.408 1.00 15.55 ? 27  VAL   B CG1  1 
ATOM   2628 C  CG2  . VAL   B 1 47  ? -19.391 18.941 24.007 1.00 13.31 ? 27  VAL   B CG2  1 
ATOM   2629 H  H    . VAL   B 1 47  ? -21.744 20.298 24.381 1.00 20.90 ? 27  VAL   B H    1 
ATOM   2630 H  HA   . VAL   B 1 47  ? -19.859 20.374 26.181 1.00 17.02 ? 27  VAL   B HA   1 
ATOM   2631 H  HB   . VAL   B 1 47  ? -19.634 20.870 23.401 1.00 17.69 ? 27  VAL   B HB   1 
ATOM   2632 H  HG11 . VAL   B 1 47  ? -17.290 20.375 23.797 1.00 18.68 ? 27  VAL   B HG11 1 
ATOM   2633 H  HG12 . VAL   B 1 47  ? -17.779 21.822 24.229 1.00 18.68 ? 27  VAL   B HG12 1 
ATOM   2634 H  HG13 . VAL   B 1 47  ? -17.597 20.683 25.324 1.00 18.68 ? 27  VAL   B HG13 1 
ATOM   2635 H  HG21 . VAL   B 1 47  ? -18.837 18.688 23.252 1.00 15.99 ? 27  VAL   B HG21 1 
ATOM   2636 H  HG22 . VAL   B 1 47  ? -19.077 18.498 24.811 1.00 15.99 ? 27  VAL   B HG22 1 
ATOM   2637 H  HG23 . VAL   B 1 47  ? -20.314 18.700 23.835 1.00 15.99 ? 27  VAL   B HG23 1 
ATOM   2638 N  N    . GLU   B 1 48  ? -20.582 23.224 24.906 1.00 16.01 ? 28  GLU   B N    1 
ATOM   2639 C  CA   . GLU   B 1 48  ? -20.486 24.656 25.158 1.00 16.55 ? 28  GLU   B CA   1 
ATOM   2640 C  C    . GLU   B 1 48  ? -21.006 25.003 26.545 1.00 14.49 ? 28  GLU   B C    1 
ATOM   2641 O  O    . GLU   B 1 48  ? -20.386 25.785 27.278 1.00 18.17 ? 28  GLU   B O    1 
ATOM   2642 C  CB   . GLU   B 1 48  ? -21.263 25.428 24.093 1.00 17.15 ? 28  GLU   B CB   1 
ATOM   2643 C  CG   . GLU   B 1 48  ? -20.704 25.272 22.694 1.00 25.16 ? 28  GLU   B CG   1 
ATOM   2644 C  CD   . GLU   B 1 48  ? -21.547 25.958 21.636 1.00 50.08 ? 28  GLU   B CD   1 
ATOM   2645 O  OE1  . GLU   B 1 48  ? -22.631 26.486 21.974 1.00 41.75 ? 28  GLU   B OE1  1 
ATOM   2646 O  OE2  . GLU   B 1 48  ? -21.121 25.960 20.462 1.00 48.01 ? 28  GLU   B OE2  1 
ATOM   2647 H  H    . GLU   B 1 48  ? -21.056 23.009 24.221 1.00 19.23 ? 28  GLU   B H    1 
ATOM   2648 H  HA   . GLU   B 1 48  ? -19.556 24.926 25.108 1.00 19.88 ? 28  GLU   B HA   1 
ATOM   2649 H  HB2  . GLU   B 1 48  ? -22.179 25.110 24.083 1.00 20.60 ? 28  GLU   B HB2  1 
ATOM   2650 H  HB3  . GLU   B 1 48  ? -21.245 26.372 24.316 1.00 20.60 ? 28  GLU   B HB3  1 
ATOM   2651 H  HG2  . GLU   B 1 48  ? -19.822 25.673 22.668 1.00 30.21 ? 28  GLU   B HG2  1 
ATOM   2652 H  HG3  . GLU   B 1 48  ? -20.648 24.330 22.474 1.00 30.21 ? 28  GLU   B HG3  1 
ATOM   2653 N  N    . GLN   B 1 49  ? -22.152 24.438 26.923 1.00 17.66 ? 29  GLN   B N    1 
ATOM   2654 C  CA   . GLN   B 1 49  ? -22.706 24.750 28.233 1.00 15.85 ? 29  GLN   B CA   1 
ATOM   2655 C  C    . GLN   B 1 49  ? -21.776 24.280 29.343 1.00 14.06 ? 29  GLN   B C    1 
ATOM   2656 O  O    . GLN   B 1 49  ? -21.532 25.013 30.309 1.00 16.45 ? 29  GLN   B O    1 
ATOM   2657 C  CB   . GLN   B 1 49  ? -24.092 24.126 28.374 1.00 20.66 ? 29  GLN   B CB   1 
ATOM   2658 C  CG   . GLN   B 1 49  ? -24.823 24.606 29.601 1.00 29.32 ? 29  GLN   B CG   1 
ATOM   2659 C  CD   . GLN   B 1 49  ? -26.063 23.792 29.903 1.00 34.55 ? 29  GLN   B CD   1 
ATOM   2660 O  OE1  . GLN   B 1 49  ? -26.733 23.287 28.998 1.00 30.25 ? 29  GLN   B OE1  1 
ATOM   2661 N  NE2  . GLN   B 1 49  ? -26.371 23.654 31.187 1.00 31.48 ? 29  GLN   B NE2  1 
ATOM   2662 H  H    . GLN   B 1 49  ? -22.615 23.886 26.453 1.00 21.21 ? 29  GLN   B H    1 
ATOM   2663 H  HA   . GLN   B 1 49  ? -22.803 25.712 28.312 1.00 19.03 ? 29  GLN   B HA   1 
ATOM   2664 H  HB2  . GLN   B 1 49  ? -24.624 24.359 27.597 1.00 24.81 ? 29  GLN   B HB2  1 
ATOM   2665 H  HB3  . GLN   B 1 49  ? -24.000 23.162 28.437 1.00 24.81 ? 29  GLN   B HB3  1 
ATOM   2666 H  HG2  . GLN   B 1 49  ? -24.234 24.545 30.369 1.00 35.20 ? 29  GLN   B HG2  1 
ATOM   2667 H  HG3  . GLN   B 1 49  ? -25.096 25.527 29.465 1.00 35.20 ? 29  GLN   B HG3  1 
ATOM   2668 H  HE21 . GLN   B 1 49  ? -25.878 24.020 31.789 1.00 37.80 ? 29  GLN   B HE21 1 
ATOM   2669 H  HE22 . GLN   B 1 49  ? -27.065 23.201 31.416 1.00 37.80 ? 29  GLN   B HE22 1 
ATOM   2670 N  N    . TYR   B 1 50  ? -21.222 23.072 29.207 1.00 16.05 ? 30  TYR   B N    1 
ATOM   2671 C  CA   . TYR   B 1 50  ? -20.268 22.569 30.193 1.00 15.81 ? 30  TYR   B CA   1 
ATOM   2672 C  C    . TYR   B 1 50  ? -19.077 23.511 30.333 1.00 16.72 ? 30  TYR   B C    1 
ATOM   2673 O  O    . TYR   B 1 50  ? -18.712 23.913 31.442 1.00 15.58 ? 30  TYR   B O    1 
ATOM   2674 C  CB   . TYR   B 1 50  ? -19.798 21.168 29.781 1.00 14.58 ? 30  TYR   B CB   1 
ATOM   2675 C  CG   . TYR   B 1 50  ? -18.896 20.482 30.779 1.00 14.43 ? 30  TYR   B CG   1 
ATOM   2676 C  CD1  . TYR   B 1 50  ? -17.563 20.863 30.920 1.00 15.13 ? 30  TYR   B CD1  1 
ATOM   2677 C  CD2  . TYR   B 1 50  ? -19.364 19.443 31.569 1.00 17.43 ? 30  TYR   B CD2  1 
ATOM   2678 C  CE1  . TYR   B 1 50  ? -16.735 20.242 31.827 1.00 17.40 ? 30  TYR   B CE1  1 
ATOM   2679 C  CE2  . TYR   B 1 50  ? -18.535 18.811 32.481 1.00 16.17 ? 30  TYR   B CE2  1 
ATOM   2680 C  CZ   . TYR   B 1 50  ? -17.223 19.214 32.606 1.00 16.85 ? 30  TYR   B CZ   1 
ATOM   2681 O  OH   . TYR   B 1 50  ? -16.404 18.584 33.516 1.00 18.36 ? 30  TYR   B OH   1 
ATOM   2682 H  H    . TYR   B 1 50  ? -21.381 22.530 28.558 1.00 19.28 ? 30  TYR   B H    1 
ATOM   2683 H  HA   . TYR   B 1 50  ? -20.705 22.502 31.056 1.00 18.99 ? 30  TYR   B HA   1 
ATOM   2684 H  HB2  . TYR   B 1 50  ? -20.578 20.605 29.656 1.00 17.51 ? 30  TYR   B HB2  1 
ATOM   2685 H  HB3  . TYR   B 1 50  ? -19.310 21.239 28.946 1.00 17.51 ? 30  TYR   B HB3  1 
ATOM   2686 H  HD1  . TYR   B 1 50  ? -17.229 21.557 30.399 1.00 18.17 ? 30  TYR   B HD1  1 
ATOM   2687 H  HD2  . TYR   B 1 50  ? -20.249 19.170 31.489 1.00 20.94 ? 30  TYR   B HD2  1 
ATOM   2688 H  HE1  . TYR   B 1 50  ? -15.849 20.512 31.911 1.00 20.90 ? 30  TYR   B HE1  1 
ATOM   2689 H  HE2  . TYR   B 1 50  ? -18.863 18.119 33.008 1.00 19.42 ? 30  TYR   B HE2  1 
ATOM   2690 H  HH   . TYR   B 1 50  ? -15.636 18.923 33.494 1.00 22.05 ? 30  TYR   B HH   1 
ATOM   2691 N  N    . MET   B 1 51  ? -18.451 23.870 29.213 1.00 13.77 ? 31  MET   B N    1 
ATOM   2692 C  CA   . MET   B 1 51  ? -17.242 24.680 29.273 1.00 15.16 ? 31  MET   B CA   1 
ATOM   2693 C  C    . MET   B 1 51  ? -17.510 26.084 29.799 1.00 16.11 ? 31  MET   B C    1 
ATOM   2694 O  O    . MET   B 1 51  ? -16.596 26.711 30.342 1.00 18.16 ? 31  MET   B O    1 
ATOM   2695 C  CB   . MET   B 1 51  ? -16.592 24.754 27.890 1.00 14.95 ? 31  MET   B CB   1 
ATOM   2696 C  CG   . MET   B 1 51  ? -16.171 23.404 27.317 1.00 15.05 ? 31  MET   B CG   1 
ATOM   2697 S  SD   . MET   B 1 51  ? -15.070 22.474 28.389 1.00 14.68 ? 31  MET   B SD   1 
ATOM   2698 C  CE   . MET   B 1 51  ? -13.811 23.702 28.729 1.00 14.70 ? 31  MET   B CE   1 
ATOM   2699 H  H    . MET   B 1 51  ? -18.703 23.660 28.418 1.00 16.54 ? 31  MET   B H    1 
ATOM   2700 H  HA   . MET   B 1 51  ? -16.613 24.248 29.871 1.00 18.21 ? 31  MET   B HA   1 
ATOM   2701 H  HB2  . MET   B 1 51  ? -17.228 25.147 27.272 1.00 17.96 ? 31  MET   B HB2  1 
ATOM   2702 H  HB3  . MET   B 1 51  ? -15.804 25.316 27.944 1.00 17.96 ? 31  MET   B HB3  1 
ATOM   2703 H  HG2  . MET   B 1 51  ? -16.962 22.864 27.169 1.00 18.07 ? 31  MET   B HG2  1 
ATOM   2704 H  HG3  . MET   B 1 51  ? -15.711 23.551 26.476 1.00 18.07 ? 31  MET   B HG3  1 
ATOM   2705 H  HE1  . MET   B 1 51  ? -13.097 23.283 29.233 1.00 17.66 ? 31  MET   B HE1  1 
ATOM   2706 H  HE2  . MET   B 1 51  ? -13.468 24.045 27.889 1.00 17.66 ? 31  MET   B HE2  1 
ATOM   2707 H  HE3  . MET   B 1 51  ? -14.202 24.422 29.248 1.00 17.66 ? 31  MET   B HE3  1 
ATOM   2708 N  N    . HIS   B 1 52  ? -18.734 26.587 29.663 1.00 15.24 ? 32  HIS   B N    1 
ATOM   2709 C  CA   . HIS   B 1 52  ? -19.074 27.918 30.145 1.00 16.64 ? 32  HIS   B CA   1 
ATOM   2710 C  C    . HIS   B 1 52  ? -19.638 27.919 31.558 1.00 21.02 ? 32  HIS   B C    1 
ATOM   2711 O  O    . HIS   B 1 52  ? -19.965 28.994 32.073 1.00 20.49 ? 32  HIS   B O    1 
ATOM   2712 C  CB   . HIS   B 1 52  ? -20.083 28.581 29.201 1.00 21.08 ? 32  HIS   B CB   1 
ATOM   2713 C  CG   . HIS   B 1 52  ? -19.502 28.971 27.881 1.00 28.05 ? 32  HIS   B CG   1 
ATOM   2714 N  ND1  . HIS   B 1 52  ? -20.138 28.727 26.682 1.00 50.27 ? 32  HIS   B ND1  1 
ATOM   2715 C  CD2  . HIS   B 1 52  ? -18.336 29.584 27.570 1.00 29.48 ? 32  HIS   B CD2  1 
ATOM   2716 C  CE1  . HIS   B 1 52  ? -19.387 29.171 25.691 1.00 43.78 ? 32  HIS   B CE1  1 
ATOM   2717 N  NE2  . HIS   B 1 52  ? -18.290 29.699 26.202 1.00 34.05 ? 32  HIS   B NE2  1 
ATOM   2718 H  H    . HIS   B 1 52  ? -19.389 26.172 29.292 1.00 18.31 ? 32  HIS   B H    1 
ATOM   2719 H  HA   . HIS   B 1 52  ? -18.272 28.463 30.149 1.00 19.99 ? 32  HIS   B HA   1 
ATOM   2720 H  HB2  . HIS   B 1 52  ? -20.810 27.961 29.034 1.00 25.31 ? 32  HIS   B HB2  1 
ATOM   2721 H  HB3  . HIS   B 1 52  ? -20.426 29.384 29.623 1.00 25.31 ? 32  HIS   B HB3  1 
ATOM   2722 H  HD1  . HIS   B 1 52  ? -20.902 28.342 26.593 1.00 60.34 ? 32  HIS   B HD1  1 
ATOM   2723 H  HD2  . HIS   B 1 52  ? -17.688 29.874 28.170 1.00 35.40 ? 32  HIS   B HD2  1 
ATOM   2724 H  HE1  . HIS   B 1 52  ? -19.598 29.126 24.786 1.00 52.55 ? 32  HIS   B HE1  1 
ATOM   2725 N  N    . THR   B 1 53  ? -19.755 26.755 32.197 1.00 20.26 ? 33  THR   B N    1 
ATOM   2726 C  CA   . THR   B 1 53  ? -20.372 26.660 33.511 1.00 16.99 ? 33  THR   B CA   1 
ATOM   2727 C  C    . THR   B 1 53  ? -19.390 27.151 34.568 1.00 20.48 ? 33  THR   B C    1 
ATOM   2728 O  O    . THR   B 1 53  ? -18.279 26.619 34.690 1.00 19.26 ? 33  THR   B O    1 
ATOM   2729 C  CB   . THR   B 1 53  ? -20.806 25.226 33.804 1.00 16.07 ? 33  THR   B CB   1 
ATOM   2730 O  OG1  . THR   B 1 53  ? -21.853 24.833 32.904 1.00 17.68 ? 33  THR   B OG1  1 
ATOM   2731 C  CG2  . THR   B 1 53  ? -21.332 25.124 35.229 1.00 18.98 ? 33  THR   B CG2  1 
ATOM   2732 H  H    . THR   B 1 53  ? -19.481 26.001 31.886 1.00 24.32 ? 33  THR   B H    1 
ATOM   2733 H  HA   . THR   B 1 53  ? -21.158 27.228 33.538 1.00 20.41 ? 33  THR   B HA   1 
ATOM   2734 H  HB   . THR   B 1 53  ? -20.049 24.628 33.707 1.00 19.31 ? 33  THR   B HB   1 
ATOM   2735 H  HG1  . THR   B 1 53  ? -21.581 24.878 32.110 1.00 21.24 ? 33  THR   B HG1  1 
ATOM   2736 H  HG21 . THR   B 1 53  ? -21.851 24.311 35.331 1.00 22.79 ? 33  THR   B HG21 1 
ATOM   2737 H  HG22 . THR   B 1 53  ? -20.594 25.105 35.858 1.00 22.79 ? 33  THR   B HG22 1 
ATOM   2738 H  HG23 . THR   B 1 53  ? -21.900 25.885 35.428 1.00 22.79 ? 33  THR   B HG23 1 
ATOM   2739 N  N    . ARG   B 1 54  ? -19.804 28.165 35.325 1.00 18.44 ? 34  ARG   B N    1 
ATOM   2740 C  CA   . ARG   B 1 54  ? -18.967 28.774 36.342 1.00 17.47 ? 34  ARG   B CA   1 
ATOM   2741 C  C    . ARG   B 1 54  ? -19.797 29.025 37.589 1.00 19.28 ? 34  ARG   B C    1 
ATOM   2742 O  O    . ARG   B 1 54  ? -21.031 28.999 37.557 1.00 23.31 ? 34  ARG   B O    1 
ATOM   2743 C  CB   . ARG   B 1 54  ? -18.372 30.106 35.874 1.00 21.87 ? 34  ARG   B CB   1 
ATOM   2744 C  CG   . ARG   B 1 54  ? -17.549 30.020 34.622 1.00 32.46 ? 34  ARG   B CG   1 
ATOM   2745 C  CD   . ARG   B 1 54  ? -16.904 31.363 34.325 1.00 38.41 ? 34  ARG   B CD   1 
ATOM   2746 N  NE   . ARG   B 1 54  ? -17.791 32.318 33.671 1.00 27.11 ? 34  ARG   B NE   1 
ATOM   2747 C  CZ   . ARG   B 1 54  ? -17.830 32.512 32.359 1.00 25.12 ? 34  ARG   B CZ   1 
ATOM   2748 N  NH1  . ARG   B 1 54  ? -17.133 31.754 31.528 1.00 25.91 ? 34  ARG   B NH1  1 
ATOM   2749 N  NH2  . ARG   B 1 54  ? -18.570 33.502 31.871 1.00 24.53 ? 34  ARG   B NH2  1 
ATOM   2750 H  H    . ARG   B 1 54  ? -20.584 28.522 35.263 1.00 22.15 ? 34  ARG   B H    1 
ATOM   2751 H  HA   . ARG   B 1 54  ? -18.240 28.174 36.571 1.00 20.98 ? 34  ARG   B HA   1 
ATOM   2752 H  HB2  . ARG   B 1 54  ? -19.098 30.727 35.706 1.00 26.26 ? 34  ARG   B HB2  1 
ATOM   2753 H  HB3  . ARG   B 1 54  ? -17.802 30.453 36.578 1.00 26.26 ? 34  ARG   B HB3  1 
ATOM   2754 H  HG2  . ARG   B 1 54  ? -16.847 29.361 34.740 1.00 38.97 ? 34  ARG   B HG2  1 
ATOM   2755 H  HG3  . ARG   B 1 54  ? -18.119 29.780 33.875 1.00 38.97 ? 34  ARG   B HG3  1 
ATOM   2756 H  HD2  . ARG   B 1 54  ? -16.624 31.760 35.164 1.00 46.11 ? 34  ARG   B HD2  1 
ATOM   2757 H  HD3  . ARG   B 1 54  ? -16.129 31.223 33.761 1.00 46.11 ? 34  ARG   B HD3  1 
ATOM   2758 H  HE   . ARG   B 1 54  ? -18.253 32.845 34.170 1.00 32.55 ? 34  ARG   B HE   1 
ATOM   2759 H  HH11 . ARG   B 1 54  ? -16.645 31.114 31.827 1.00 31.11 ? 34  ARG   B HH11 1 
ATOM   2760 H  HH12 . ARG   B 1 54  ? -17.175 31.899 30.681 1.00 31.11 ? 34  ARG   B HH12 1 
ATOM   2761 H  HH21 . ARG   B 1 54  ? -19.028 33.999 32.403 1.00 29.45 ? 34  ARG   B HH21 1 
ATOM   2762 H  HH22 . ARG   B 1 54  ? -18.607 33.633 31.022 1.00 29.45 ? 34  ARG   B HH22 1 
ATOM   2763 N  N    . GLY   B 1 55  ? -19.100 29.298 38.689 1.00 20.47 ? 35  GLY   B N    1 
ATOM   2764 C  CA   . GLY   B 1 55  ? -19.769 29.737 39.900 1.00 26.71 ? 35  GLY   B CA   1 
ATOM   2765 C  C    . GLY   B 1 55  ? -20.758 28.708 40.400 1.00 25.24 ? 35  GLY   B C    1 
ATOM   2766 O  O    . GLY   B 1 55  ? -20.536 27.497 40.311 1.00 21.21 ? 35  GLY   B O    1 
ATOM   2767 H  H    . GLY   B 1 55  ? -18.245 29.236 38.756 1.00 24.58 ? 35  GLY   B H    1 
ATOM   2768 H  HA2  . GLY   B 1 55  ? -19.111 29.897 40.595 1.00 32.07 ? 35  GLY   B HA2  1 
ATOM   2769 H  HA3  . GLY   B 1 55  ? -20.245 30.565 39.727 1.00 32.07 ? 35  GLY   B HA3  1 
ATOM   2770 N  N    . GLU   B 1 56  ? -21.878 29.195 40.929 1.00 26.42 ? 36  GLU   B N    1 
ATOM   2771 C  CA   . GLU   B 1 56  ? -22.832 28.300 41.565 1.00 24.83 ? 36  GLU   B CA   1 
ATOM   2772 C  C    . GLU   B 1 56  ? -23.485 27.345 40.577 1.00 23.40 ? 36  GLU   B C    1 
ATOM   2773 O  O    . GLU   B 1 56  ? -23.979 26.291 40.991 1.00 22.10 ? 36  GLU   B O    1 
ATOM   2774 C  CB   . GLU   B 1 56  ? -23.907 29.112 42.292 1.00 35.69 ? 36  GLU   B CB   1 
ATOM   2775 C  CG   . GLU   B 1 56  ? -23.357 30.003 43.390 1.00 48.64 ? 36  GLU   B CG   1 
ATOM   2776 C  CD   . GLU   B 1 56  ? -22.666 29.218 44.487 1.00 64.28 ? 36  GLU   B CD   1 
ATOM   2777 O  OE1  . GLU   B 1 56  ? -23.364 28.515 45.249 1.00 57.07 ? 36  GLU   B OE1  1 
ATOM   2778 O  OE2  . GLU   B 1 56  ? -21.422 29.296 44.579 1.00 60.29 ? 36  GLU   B OE2  1 
ATOM   2779 H  H    . GLU   B 1 56  ? -22.104 30.025 40.932 1.00 31.72 ? 36  GLU   B H    1 
ATOM   2780 H  HA   . GLU   B 1 56  ? -22.364 27.765 42.225 1.00 29.81 ? 36  GLU   B HA   1 
ATOM   2781 H  HB2  . GLU   B 1 56  ? -24.360 29.679 41.648 1.00 42.85 ? 36  GLU   B HB2  1 
ATOM   2782 H  HB3  . GLU   B 1 56  ? -24.542 28.500 42.696 1.00 42.85 ? 36  GLU   B HB3  1 
ATOM   2783 H  HG2  . GLU   B 1 56  ? -22.711 30.616 43.007 1.00 58.39 ? 36  GLU   B HG2  1 
ATOM   2784 H  HG3  . GLU   B 1 56  ? -24.088 30.499 43.791 1.00 58.39 ? 36  GLU   B HG3  1 
ATOM   2785 N  N    . ALA   B 1 57  ? -23.503 27.683 39.288 1.00 20.84 ? 37  ALA   B N    1 
ATOM   2786 C  CA   . ALA   B 1 57  ? -24.037 26.754 38.301 1.00 23.78 ? 37  ALA   B CA   1 
ATOM   2787 C  C    . ALA   B 1 57  ? -23.257 25.445 38.271 1.00 18.67 ? 37  ALA   B C    1 
ATOM   2788 O  O    . ALA   B 1 57  ? -23.779 24.435 37.786 1.00 18.43 ? 37  ALA   B O    1 
ATOM   2789 C  CB   . ALA   B 1 57  ? -24.032 27.394 36.910 1.00 22.79 ? 37  ALA   B CB   1 
ATOM   2790 H  H    . ALA   B 1 57  ? -23.218 28.428 38.967 1.00 25.03 ? 37  ALA   B H    1 
ATOM   2791 H  HA   . ALA   B 1 57  ? -24.957 26.547 38.530 1.00 28.56 ? 37  ALA   B HA   1 
ATOM   2792 H  HB1  . ALA   B 1 57  ? -24.391 26.760 36.270 1.00 27.36 ? 37  ALA   B HB1  1 
ATOM   2793 H  HB2  . ALA   B 1 57  ? -24.582 28.193 36.928 1.00 27.36 ? 37  ALA   B HB2  1 
ATOM   2794 H  HB3  . ALA   B 1 57  ? -23.120 27.625 36.672 1.00 27.36 ? 37  ALA   B HB3  1 
ATOM   2795 N  N    . ARG   B 1 58  ? -22.013 25.440 38.760 1.00 20.30 ? 38  ARG   B N    1 
ATOM   2796 C  CA   . ARG   B 1 58  ? -21.245 24.200 38.818 1.00 17.30 ? 38  ARG   B CA   1 
ATOM   2797 C  C    . ARG   B 1 58  ? -21.932 23.151 39.679 1.00 17.22 ? 38  ARG   B C    1 
ATOM   2798 O  O    . ARG   B 1 58  ? -21.685 21.955 39.498 1.00 18.81 ? 38  ARG   B O    1 
ATOM   2799 C  CB   . ARG   B 1 58  ? -19.839 24.498 39.332 1.00 19.67 ? 38  ARG   B CB   1 
ATOM   2800 C  CG   . ARG   B 1 58  ? -19.021 25.288 38.320 1.00 22.77 ? 38  ARG   B CG   1 
ATOM   2801 C  CD   . ARG   B 1 58  ? -17.919 26.095 38.973 1.00 22.49 ? 38  ARG   B CD   1 
ATOM   2802 N  NE   . ARG   B 1 58  ? -16.930 25.238 39.613 1.00 23.33 ? 38  ARG   B NE   1 
ATOM   2803 C  CZ   . ARG   B 1 58  ? -15.935 25.682 40.368 1.00 24.85 ? 38  ARG   B CZ   1 
ATOM   2804 N  NH1  . ARG   B 1 58  ? -15.786 26.968 40.628 1.00 24.69 ? 38  ARG   B NH1  1 
ATOM   2805 N  NH2  . ARG   B 1 58  ? -15.066 24.811 40.874 1.00 21.43 ? 38  ARG   B NH2  1 
ATOM   2806 H  H    . ARG   B 1 58  ? -21.599 26.132 39.059 1.00 24.38 ? 38  ARG   B H    1 
ATOM   2807 H  HA   . ARG   B 1 58  ? -21.163 23.840 37.921 1.00 20.77 ? 38  ARG   B HA   1 
ATOM   2808 H  HB2  . ARG   B 1 58  ? -19.901 25.022 40.146 1.00 23.63 ? 38  ARG   B HB2  1 
ATOM   2809 H  HB3  . ARG   B 1 58  ? -19.379 23.662 39.506 1.00 23.63 ? 38  ARG   B HB3  1 
ATOM   2810 H  HG2  . ARG   B 1 58  ? -18.611 24.671 37.693 1.00 27.35 ? 38  ARG   B HG2  1 
ATOM   2811 H  HG3  . ARG   B 1 58  ? -19.605 25.903 37.849 1.00 27.35 ? 38  ARG   B HG3  1 
ATOM   2812 H  HD2  . ARG   B 1 58  ? -17.469 26.625 38.297 1.00 27.01 ? 38  ARG   B HD2  1 
ATOM   2813 H  HD3  . ARG   B 1 58  ? -18.303 26.672 39.651 1.00 27.01 ? 38  ARG   B HD3  1 
ATOM   2814 H  HE   . ARG   B 1 58  ? -16.996 24.389 39.493 1.00 28.01 ? 38  ARG   B HE   1 
ATOM   2815 H  HH11 . ARG   B 1 58  ? -16.340 27.541 40.306 1.00 29.64 ? 38  ARG   B HH11 1 
ATOM   2816 H  HH12 . ARG   B 1 58  ? -15.133 27.233 41.121 1.00 29.64 ? 38  ARG   B HH12 1 
ATOM   2817 H  HH21 . ARG   B 1 58  ? -15.155 23.971 40.711 1.00 25.74 ? 38  ARG   B HH21 1 
ATOM   2818 H  HH22 . ARG   B 1 58  ? -14.418 25.087 41.367 1.00 25.74 ? 38  ARG   B HH22 1 
ATOM   2819 N  N    . LEU   B 1 59  ? -22.805 23.569 40.593 1.00 19.09 ? 39  LEU   B N    1 
ATOM   2820 C  CA   . LEU   B 1 59  ? -23.524 22.611 41.420 1.00 20.12 ? 39  LEU   B CA   1 
ATOM   2821 C  C    . LEU   B 1 59  ? -24.517 21.776 40.623 1.00 22.74 ? 39  LEU   B C    1 
ATOM   2822 O  O    . LEU   B 1 59  ? -24.939 20.721 41.105 1.00 22.94 ? 39  LEU   B O    1 
ATOM   2823 C  CB   . LEU   B 1 59  ? -24.245 23.345 42.548 1.00 20.14 ? 39  LEU   B CB   1 
ATOM   2824 C  CG   . LEU   B 1 59  ? -23.318 23.976 43.584 1.00 27.15 ? 39  LEU   B CG   1 
ATOM   2825 C  CD1  . LEU   B 1 59  ? -24.114 24.764 44.614 1.00 29.63 ? 39  LEU   B CD1  1 
ATOM   2826 C  CD2  . LEU   B 1 59  ? -22.456 22.917 44.266 1.00 32.77 ? 39  LEU   B CD2  1 
ATOM   2827 H  H    . LEU   B 1 59  ? -22.996 24.392 40.752 1.00 22.92 ? 39  LEU   B H    1 
ATOM   2828 H  HA   . LEU   B 1 59  ? -22.884 21.999 41.815 1.00 24.16 ? 39  LEU   B HA   1 
ATOM   2829 H  HB2  . LEU   B 1 59  ? -24.783 24.055 42.163 1.00 24.19 ? 39  LEU   B HB2  1 
ATOM   2830 H  HB3  . LEU   B 1 59  ? -24.819 22.715 43.011 1.00 24.19 ? 39  LEU   B HB3  1 
ATOM   2831 H  HG   . LEU   B 1 59  ? -22.723 24.596 43.133 1.00 32.60 ? 39  LEU   B HG   1 
ATOM   2832 H  HD11 . LEU   B 1 59  ? -23.500 25.158 45.253 1.00 35.58 ? 39  LEU   B HD11 1 
ATOM   2833 H  HD12 . LEU   B 1 59  ? -24.613 25.462 44.161 1.00 35.58 ? 39  LEU   B HD12 1 
ATOM   2834 H  HD13 . LEU   B 1 59  ? -24.725 24.162 45.068 1.00 35.58 ? 39  LEU   B HD13 1 
ATOM   2835 H  HD21 . LEU   B 1 59  ? -22.036 23.308 45.048 1.00 39.35 ? 39  LEU   B HD21 1 
ATOM   2836 H  HD22 . LEU   B 1 59  ? -23.021 22.174 44.531 1.00 39.35 ? 39  LEU   B HD22 1 
ATOM   2837 H  HD23 . LEU   B 1 59  ? -21.777 22.611 43.645 1.00 39.35 ? 39  LEU   B HD23 1 
ATOM   2838 N  N    . LYS   B 1 60  ? -24.898 22.213 39.422 1.00 20.36 ? 40  LYS   B N    1 
ATOM   2839 C  CA   . LYS   B 1 60  ? -25.830 21.460 38.593 1.00 17.23 ? 40  LYS   B CA   1 
ATOM   2840 C  C    . LYS   B 1 60  ? -25.188 20.931 37.314 1.00 17.95 ? 40  LYS   B C    1 
ATOM   2841 O  O    . LYS   B 1 60  ? -25.889 20.377 36.462 1.00 18.15 ? 40  LYS   B O    1 
ATOM   2842 C  CB   . LYS   B 1 60  ? -27.053 22.316 38.250 1.00 23.07 ? 40  LYS   B CB   1 
ATOM   2843 C  CG   . LYS   B 1 60  ? -27.972 22.610 39.441 1.00 33.74 ? 40  LYS   B CG   1 
ATOM   2844 C  CD   . LYS   B 1 60  ? -28.455 21.329 40.115 1.00 44.12 ? 40  LYS   B CD   1 
ATOM   2845 C  CE   . LYS   B 1 60  ? -29.202 21.610 41.418 1.00 65.80 ? 40  LYS   B CE   1 
ATOM   2846 N  NZ   . LYS   B 1 60  ? -29.400 20.360 42.209 1.00 64.40 ? 40  LYS   B NZ   1 
ATOM   2847 H  H    . LYS   B 1 60  ? -24.628 22.947 39.065 1.00 24.45 ? 40  LYS   B H    1 
ATOM   2848 H  HA   . LYS   B 1 60  ? -26.123 20.680 39.082 1.00 20.70 ? 40  LYS   B HA   1 
ATOM   2849 H  HB2  . LYS   B 1 60  ? -26.748 23.166 37.896 1.00 27.70 ? 40  LYS   B HB2  1 
ATOM   2850 H  HB3  . LYS   B 1 60  ? -27.579 21.853 37.580 1.00 27.70 ? 40  LYS   B HB3  1 
ATOM   2851 H  HG2  . LYS   B 1 60  ? -27.486 23.133 40.098 1.00 40.51 ? 40  LYS   B HG2  1 
ATOM   2852 H  HG3  . LYS   B 1 60  ? -28.749 23.101 39.131 1.00 40.51 ? 40  LYS   B HG3  1 
ATOM   2853 H  HD2  . LYS   B 1 60  ? -29.056 20.860 39.516 1.00 52.96 ? 40  LYS   B HD2  1 
ATOM   2854 H  HD3  . LYS   B 1 60  ? -27.704 20.765 40.344 1.00 52.96 ? 40  LYS   B HD3  1 
ATOM   2855 H  HE2  . LYS   B 1 60  ? -28.687 22.232 41.955 1.00 78.98 ? 40  LYS   B HE2  1 
ATOM   2856 H  HE3  . LYS   B 1 60  ? -30.074 21.983 41.214 1.00 78.98 ? 40  LYS   B HE3  1 
ATOM   2857 H  HZ1  . LYS   B 1 60  ? -29.836 20.543 42.963 1.00 77.30 ? 40  LYS   B HZ1  1 
ATOM   2858 H  HZ2  . LYS   B 1 60  ? -29.874 19.773 41.736 1.00 77.30 ? 40  LYS   B HZ2  1 
ATOM   2859 H  HZ3  . LYS   B 1 60  ? -28.612 20.000 42.411 1.00 77.30 ? 40  LYS   B HZ3  1 
ATOM   2860 N  N    . ARG   B 1 61  ? -23.866 21.061 37.165 1.00 18.56 ? 41  ARG   B N    1 
ATOM   2861 C  CA   . ARG   B 1 61  ? -23.228 20.609 35.934 1.00 17.67 ? 41  ARG   B CA   1 
ATOM   2862 C  C    . ARG   B 1 61  ? -23.373 19.104 35.745 1.00 16.16 ? 41  ARG   B C    1 
ATOM   2863 O  O    . ARG   B 1 61  ? -23.384 18.620 34.609 1.00 16.99 ? 41  ARG   B O    1 
ATOM   2864 C  CB   . ARG   B 1 61  ? -21.756 21.010 35.931 1.00 17.46 ? 41  ARG   B CB   1 
ATOM   2865 C  CG   . ARG   B 1 61  ? -21.088 20.914 34.572 1.00 13.10 ? 41  ARG   B CG   1 
ATOM   2866 C  CD   . ARG   B 1 61  ? -19.652 21.399 34.658 1.00 16.15 ? 41  ARG   B CD   1 
ATOM   2867 N  NE   . ARG   B 1 61  ? -18.836 20.503 35.472 1.00 22.91 ? 41  ARG   B NE   1 
ATOM   2868 C  CZ   . ARG   B 1 61  ? -17.614 20.779 35.909 1.00 29.07 ? 41  ARG   B CZ   1 
ATOM   2869 N  NH1  . ARG   B 1 61  ? -17.030 21.937 35.649 1.00 23.49 ? 41  ARG   B NH1  1 
ATOM   2870 N  NH2  . ARG   B 1 61  ? -16.965 19.873 36.633 1.00 27.89 ? 41  ARG   B NH2  1 
ATOM   2871 H  H    . ARG   B 1 61  ? -23.331 21.399 37.747 1.00 22.29 ? 41  ARG   B H    1 
ATOM   2872 H  HA   . ARG   B 1 61  ? -23.656 21.045 35.181 1.00 21.23 ? 41  ARG   B HA   1 
ATOM   2873 H  HB2  . ARG   B 1 61  ? -21.683 21.929 36.231 1.00 20.97 ? 41  ARG   B HB2  1 
ATOM   2874 H  HB3  . ARG   B 1 61  ? -21.274 20.428 36.539 1.00 20.97 ? 41  ARG   B HB3  1 
ATOM   2875 H  HG2  . ARG   B 1 61  ? -21.084 19.990 34.277 1.00 15.74 ? 41  ARG   B HG2  1 
ATOM   2876 H  HG3  . ARG   B 1 61  ? -21.564 21.471 33.937 1.00 15.74 ? 41  ARG   B HG3  1 
ATOM   2877 H  HD2  . ARG   B 1 61  ? -19.271 21.432 33.767 1.00 19.40 ? 41  ARG   B HD2  1 
ATOM   2878 H  HD3  . ARG   B 1 61  ? -19.635 22.280 35.064 1.00 19.40 ? 41  ARG   B HD3  1 
ATOM   2879 H  HE   . ARG   B 1 61  ? -19.172 19.740 35.684 1.00 27.50 ? 41  ARG   B HE   1 
ATOM   2880 H  HH11 . ARG   B 1 61  ? -17.439 22.532 35.182 1.00 28.21 ? 41  ARG   B HH11 1 
ATOM   2881 H  HH12 . ARG   B 1 61  ? -16.238 22.094 35.944 1.00 28.21 ? 41  ARG   B HH12 1 
ATOM   2882 H  HH21 . ARG   B 1 61  ? -17.336 19.117 36.809 1.00 33.49 ? 41  ARG   B HH21 1 
ATOM   2883 H  HH22 . ARG   B 1 61  ? -16.173 20.042 36.923 1.00 33.49 ? 41  ARG   B HH22 1 
ATOM   2884 N  N    . HIS   B 1 62  ? -23.514 18.350 36.837 1.00 16.65 ? 42  HIS   B N    1 
ATOM   2885 C  CA   . HIS   B 1 62  ? -23.663 16.903 36.726 1.00 16.94 ? 42  HIS   B CA   1 
ATOM   2886 C  C    . HIS   B 1 62  ? -24.945 16.510 36.003 1.00 16.75 ? 42  HIS   B C    1 
ATOM   2887 O  O    . HIS   B 1 62  ? -25.048 15.375 35.524 1.00 15.59 ? 42  HIS   B O    1 
ATOM   2888 C  CB   . HIS   B 1 62  ? -23.619 16.271 38.123 1.00 17.14 ? 42  HIS   B CB   1 
ATOM   2889 C  CG   . HIS   B 1 62  ? -24.764 16.672 38.997 1.00 15.14 ? 42  HIS   B CG   1 
ATOM   2890 N  ND1  . HIS   B 1 62  ? -24.874 17.929 39.553 1.00 19.79 ? 42  HIS   B ND1  1 
ATOM   2891 C  CD2  . HIS   B 1 62  ? -25.848 15.980 39.415 1.00 20.21 ? 42  HIS   B CD2  1 
ATOM   2892 C  CE1  . HIS   B 1 62  ? -25.979 17.994 40.272 1.00 25.12 ? 42  HIS   B CE1  1 
ATOM   2893 N  NE2  . HIS   B 1 62  ? -26.592 16.827 40.199 1.00 20.51 ? 42  HIS   B NE2  1 
ATOM   2894 H  H    . HIS   B 1 62  ? -23.525 18.650 37.643 1.00 20.00 ? 42  HIS   B H    1 
ATOM   2895 H  HA   . HIS   B 1 62  ? -22.916 16.550 36.217 1.00 20.35 ? 42  HIS   B HA   1 
ATOM   2896 H  HB2  . HIS   B 1 62  ? -23.639 15.306 38.031 1.00 20.59 ? 42  HIS   B HB2  1 
ATOM   2897 H  HB3  . HIS   B 1 62  ? -22.799 16.543 38.564 1.00 20.59 ? 42  HIS   B HB3  1 
ATOM   2898 H  HD2  . HIS   B 1 62  ? -26.057 15.100 39.202 1.00 24.27 ? 42  HIS   B HD2  1 
ATOM   2899 H  HE1  . HIS   B 1 62  ? -26.278 18.737 40.745 1.00 30.16 ? 42  HIS   B HE1  1 
ATOM   2900 H  HE2  . HIS   B 1 62  ? -27.331 16.626 40.590 1.00 24.63 ? 42  HIS   B HE2  1 
ATOM   2901 N  N    . LEU   B 1 63  ? -25.927 17.415 35.907 1.00 17.28 ? 43  LEU   B N    1 
ATOM   2902 C  CA   . LEU   B 1 63  ? -27.136 17.121 35.150 1.00 15.29 ? 43  LEU   B CA   1 
ATOM   2903 C  C    . LEU   B 1 63  ? -26.874 17.039 33.652 1.00 18.32 ? 43  LEU   B C    1 
ATOM   2904 O  O    . LEU   B 1 63  ? -27.762 16.614 32.902 1.00 17.58 ? 43  LEU   B O    1 
ATOM   2905 C  CB   . LEU   B 1 63  ? -28.214 18.165 35.458 1.00 16.81 ? 43  LEU   B CB   1 
ATOM   2906 C  CG   . LEU   B 1 63  ? -28.667 18.216 36.918 1.00 22.14 ? 43  LEU   B CG   1 
ATOM   2907 C  CD1  . LEU   B 1 63  ? -29.773 19.250 37.110 1.00 26.18 ? 43  LEU   B CD1  1 
ATOM   2908 C  CD2  . LEU   B 1 63  ? -29.133 16.851 37.408 1.00 21.90 ? 43  LEU   B CD2  1 
ATOM   2909 H  H    . LEU   B 1 63  ? -25.913 18.195 36.268 1.00 20.75 ? 43  LEU   B H    1 
ATOM   2910 H  HA   . LEU   B 1 63  ? -27.471 16.255 35.428 1.00 18.37 ? 43  LEU   B HA   1 
ATOM   2911 H  HB2  . LEU   B 1 63  ? -27.869 19.042 35.228 1.00 20.19 ? 43  LEU   B HB2  1 
ATOM   2912 H  HB3  . LEU   B 1 63  ? -28.995 17.971 34.916 1.00 20.19 ? 43  LEU   B HB3  1 
ATOM   2913 H  HG   . LEU   B 1 63  ? -27.914 18.485 37.467 1.00 26.59 ? 43  LEU   B HG   1 
ATOM   2914 H  HD11 . LEU   B 1 63  ? -30.035 19.262 38.044 1.00 31.44 ? 43  LEU   B HD11 1 
ATOM   2915 H  HD12 . LEU   B 1 63  ? -29.438 20.122 36.849 1.00 31.44 ? 43  LEU   B HD12 1 
ATOM   2916 H  HD13 . LEU   B 1 63  ? -30.531 19.007 36.556 1.00 31.44 ? 43  LEU   B HD13 1 
ATOM   2917 H  HD21 . LEU   B 1 63  ? -29.582 16.959 38.261 1.00 26.30 ? 43  LEU   B HD21 1 
ATOM   2918 H  HD22 . LEU   B 1 63  ? -29.746 16.475 36.757 1.00 26.30 ? 43  LEU   B HD22 1 
ATOM   2919 H  HD23 . LEU   B 1 63  ? -28.362 16.271 37.511 1.00 26.30 ? 43  LEU   B HD23 1 
ATOM   2920 N  N    . LEU   B 1 64  ? -25.677 17.402 33.204 1.00 15.23 ? 44  LEU   B N    1 
ATOM   2921 C  CA   . LEU   B 1 64  ? -25.310 17.238 31.805 1.00 14.96 ? 44  LEU   B CA   1 
ATOM   2922 C  C    . LEU   B 1 64  ? -24.818 15.828 31.496 1.00 16.64 ? 44  LEU   B C    1 
ATOM   2923 O  O    . LEU   B 1 64  ? -24.506 15.539 30.333 1.00 16.14 ? 44  LEU   B O    1 
ATOM   2924 C  CB   . LEU   B 1 64  ? -24.236 18.261 31.429 1.00 15.32 ? 44  LEU   B CB   1 
ATOM   2925 C  CG   . LEU   B 1 64  ? -24.642 19.733 31.557 1.00 21.74 ? 44  LEU   B CG   1 
ATOM   2926 C  CD1  . LEU   B 1 64  ? -23.499 20.663 31.135 1.00 21.19 ? 44  LEU   B CD1  1 
ATOM   2927 C  CD2  . LEU   B 1 64  ? -25.908 20.021 30.749 1.00 19.13 ? 44  LEU   B CD2  1 
ATOM   2928 H  H    . LEU   B 1 64  ? -25.058 17.748 33.690 1.00 18.29 ? 44  LEU   B H    1 
ATOM   2929 H  HA   . LEU   B 1 64  ? -26.090 17.402 31.254 1.00 17.97 ? 44  LEU   B HA   1 
ATOM   2930 H  HB2  . LEU   B 1 64  ? -23.467 18.122 32.003 1.00 18.40 ? 44  LEU   B HB2  1 
ATOM   2931 H  HB3  . LEU   B 1 64  ? -23.980 18.110 30.505 1.00 18.40 ? 44  LEU   B HB3  1 
ATOM   2932 H  HG   . LEU   B 1 64  ? -24.841 19.918 32.488 1.00 26.10 ? 44  LEU   B HG   1 
ATOM   2933 H  HD11 . LEU   B 1 64  ? -23.790 21.583 31.230 1.00 25.45 ? 44  LEU   B HD11 1 
ATOM   2934 H  HD12 . LEU   B 1 64  ? -22.731 20.497 31.704 1.00 25.45 ? 44  LEU   B HD12 1 
ATOM   2935 H  HD13 . LEU   B 1 64  ? -23.271 20.482 30.210 1.00 25.45 ? 44  LEU   B HD13 1 
ATOM   2936 H  HD21 . LEU   B 1 64  ? -26.043 20.981 30.706 1.00 22.97 ? 44  LEU   B HD21 1 
ATOM   2937 H  HD22 . LEU   B 1 64  ? -25.799 19.662 29.855 1.00 22.97 ? 44  LEU   B HD22 1 
ATOM   2938 H  HD23 . LEU   B 1 64  ? -26.665 19.600 31.185 1.00 22.97 ? 44  LEU   B HD23 1 
ATOM   2939 N  N    . PHE   B 1 65  ? -24.759 14.953 32.499 1.00 14.14 ? 45  PHE   B N    1 
ATOM   2940 C  CA   . PHE   B 1 65  ? -24.268 13.594 32.341 1.00 16.28 ? 45  PHE   B CA   1 
ATOM   2941 C  C    . PHE   B 1 65  ? -25.400 12.571 32.342 1.00 17.56 ? 45  PHE   B C    1 
ATOM   2942 O  O    . PHE   B 1 65  ? -26.488 12.798 32.880 1.00 17.86 ? 45  PHE   B O    1 
ATOM   2943 C  CB   . PHE   B 1 65  ? -23.298 13.232 33.474 1.00 15.41 ? 45  PHE   B CB   1 
ATOM   2944 C  CG   . PHE   B 1 65  ? -21.964 13.920 33.402 1.00 15.59 ? 45  PHE   B CG   1 
ATOM   2945 C  CD1  . PHE   B 1 65  ? -21.815 15.249 33.780 1.00 15.70 ? 45  PHE   B CD1  1 
ATOM   2946 C  CD2  . PHE   B 1 65  ? -20.840 13.218 32.992 1.00 16.67 ? 45  PHE   B CD2  1 
ATOM   2947 C  CE1  . PHE   B 1 65  ? -20.567 15.868 33.720 1.00 20.47 ? 45  PHE   B CE1  1 
ATOM   2948 C  CE2  . PHE   B 1 65  ? -19.597 13.830 32.936 1.00 13.84 ? 45  PHE   B CE2  1 
ATOM   2949 C  CZ   . PHE   B 1 65  ? -19.461 15.153 33.299 1.00 14.70 ? 45  PHE   B CZ   1 
ATOM   2950 H  H    . PHE   B 1 65  ? -25.006 15.131 33.303 1.00 16.99 ? 45  PHE   B H    1 
ATOM   2951 H  HA   . PHE   B 1 65  ? -23.792 13.521 31.499 1.00 19.55 ? 45  PHE   B HA   1 
ATOM   2952 H  HB2  . PHE   B 1 65  ? -23.707 13.472 34.320 1.00 18.50 ? 45  PHE   B HB2  1 
ATOM   2953 H  HB3  . PHE   B 1 65  ? -23.137 12.276 33.450 1.00 18.50 ? 45  PHE   B HB3  1 
ATOM   2954 H  HD1  . PHE   B 1 65  ? -22.557 15.734 34.062 1.00 18.86 ? 45  PHE   B HD1  1 
ATOM   2955 H  HD2  . PHE   B 1 65  ? -20.923 12.326 32.744 1.00 20.02 ? 45  PHE   B HD2  1 
ATOM   2956 H  HE1  . PHE   B 1 65  ? -20.478 16.760 33.967 1.00 24.58 ? 45  PHE   B HE1  1 
ATOM   2957 H  HE2  . PHE   B 1 65  ? -18.855 13.348 32.650 1.00 16.63 ? 45  PHE   B HE2  1 
ATOM   2958 H  HZ   . PHE   B 1 65  ? -18.628 15.564 33.259 1.00 17.66 ? 45  PHE   B HZ   1 
ATOM   2959 N  N    . THR   B 1 66  ? -25.105 11.409 31.770 1.00 15.14 ? 46  THR   B N    1 
ATOM   2960 C  CA   . THR   B 1 66  ? -25.968 10.255 31.949 1.00 18.65 ? 46  THR   B CA   1 
ATOM   2961 C  C    . THR   B 1 66  ? -25.912 9.792  33.405 1.00 20.84 ? 46  THR   B C    1 
ATOM   2962 O  O    . THR   B 1 66  ? -24.999 10.141 34.158 1.00 17.90 ? 46  THR   B O    1 
ATOM   2963 C  CB   . THR   B 1 66  ? -25.549 9.117  31.023 1.00 22.85 ? 46  THR   B CB   1 
ATOM   2964 O  OG1  . THR   B 1 66  ? -24.227 8.693  31.362 1.00 20.36 ? 46  THR   B OG1  1 
ATOM   2965 C  CG2  . THR   B 1 66  ? -25.579 9.569  29.572 1.00 22.42 ? 46  THR   B CG2  1 
ATOM   2966 H  H    . THR   B 1 66  ? -24.415 11.266 31.278 1.00 18.18 ? 46  THR   B H    1 
ATOM   2967 H  HA   . THR   B 1 66  ? -26.883 10.500 31.740 1.00 22.40 ? 46  THR   B HA   1 
ATOM   2968 H  HB   . THR   B 1 66  ? -26.163 8.373  31.126 1.00 27.43 ? 46  THR   B HB   1 
ATOM   2969 H  HG1  . THR   B 1 66  ? -24.231 8.310  32.109 1.00 24.45 ? 46  THR   B HG1  1 
ATOM   2970 H  HG21 . THR   B 1 66  ? -25.385 8.819  28.988 1.00 26.93 ? 46  THR   B HG21 1 
ATOM   2971 H  HG22 . THR   B 1 66  ? -26.456 9.920  29.353 1.00 26.93 ? 46  THR   B HG22 1 
ATOM   2972 H  HG23 . THR   B 1 66  ? -24.917 10.262 29.426 1.00 26.93 ? 46  THR   B HG23 1 
ATOM   2973 N  N    . GLU   B 1 67  ? -26.909 8.993  33.798 1.00 20.46 ? 47  GLU   B N    1 
ATOM   2974 C  CA   . GLU   B 1 67  ? -26.975 8.529  35.182 1.00 22.99 ? 47  GLU   B CA   1 
ATOM   2975 C  C    . GLU   B 1 67  ? -25.684 7.833  35.591 1.00 20.08 ? 47  GLU   B C    1 
ATOM   2976 O  O    . GLU   B 1 67  ? -25.200 8.004  36.718 1.00 19.91 ? 47  GLU   B O    1 
ATOM   2977 C  CB   . GLU   B 1 67  ? -28.167 7.589  35.366 1.00 29.07 ? 47  GLU   B CB   1 
ATOM   2978 C  CG   . GLU   B 1 67  ? -29.506 8.254  35.120 1.00 47.69 ? 47  GLU   B CG   1 
ATOM   2979 C  CD   . GLU   B 1 67  ? -30.660 7.272  35.141 1.00 56.41 ? 47  GLU   B CD   1 
ATOM   2980 O  OE1  . GLU   B 1 67  ? -30.860 6.563  34.129 1.00 45.59 ? 47  GLU   B OE1  1 
ATOM   2981 O  OE2  . GLU   B 1 67  ? -31.361 7.209  36.173 1.00 51.34 ? 47  GLU   B OE2  1 
ATOM   2982 H  H    . GLU   B 1 67  ? -27.545 8.712  33.293 1.00 24.57 ? 47  GLU   B H    1 
ATOM   2983 H  HA   . GLU   B 1 67  ? -27.102 9.293  35.766 1.00 27.60 ? 47  GLU   B HA   1 
ATOM   2984 H  HB2  . GLU   B 1 67  ? -28.083 6.850  34.743 1.00 34.90 ? 47  GLU   B HB2  1 
ATOM   2985 H  HB3  . GLU   B 1 67  ? -28.164 7.254  36.276 1.00 34.90 ? 47  GLU   B HB3  1 
ATOM   2986 H  HG2  . GLU   B 1 67  ? -29.662 8.904  35.817 1.00 57.25 ? 47  GLU   B HG2  1 
ATOM   2987 H  HG3  . GLU   B 1 67  ? -29.494 8.688  34.253 1.00 57.25 ? 47  GLU   B HG3  1 
ATOM   2988 N  N    . ASP   B 1 68  ? -25.115 7.041  34.685 1.00 20.65 ? 48  ASP   B N    1 
ATOM   2989 C  CA   . ASP   B 1 68  ? -23.886 6.306  34.937 1.00 22.53 ? 48  ASP   B CA   1 
ATOM   2990 C  C    . ASP   B 1 68  ? -22.669 6.996  34.341 1.00 23.22 ? 48  ASP   B C    1 
ATOM   2991 O  O    . ASP   B 1 68  ? -21.637 6.352  34.142 1.00 23.81 ? 48  ASP   B O    1 
ATOM   2992 C  CB   . ASP   B 1 68  ? -24.003 4.886  34.378 1.00 28.56 ? 48  ASP   B CB   1 
ATOM   2993 C  CG   . ASP   B 1 68  ? -24.191 4.863  32.862 1.00 44.96 ? 48  ASP   B CG   1 
ATOM   2994 O  OD1  . ASP   B 1 68  ? -24.412 5.934  32.256 1.00 37.44 ? 48  ASP   B OD1  1 
ATOM   2995 O  OD2  . ASP   B 1 68  ? -24.111 3.765  32.270 1.00 52.06 ? 48  ASP   B OD2  1 
ATOM   2996 H  H    . ASP   B 1 68  ? -25.434 6.913  33.897 1.00 24.80 ? 48  ASP   B H    1 
ATOM   2997 H  HA   . ASP   B 1 68  ? -23.750 6.238  35.895 1.00 27.05 ? 48  ASP   B HA   1 
ATOM   2998 H  HB2  . ASP   B 1 68  ? -23.193 4.396  34.588 1.00 34.29 ? 48  ASP   B HB2  1 
ATOM   2999 H  HB3  . ASP   B 1 68  ? -24.769 4.449  34.782 1.00 34.29 ? 48  ASP   B HB3  1 
ATOM   3000 N  N    . GLY   B 1 69  ? -22.775 8.285  34.041 1.00 17.50 ? 49  GLY   B N    1 
ATOM   3001 C  CA   . GLY   B 1 69  ? -21.672 8.989  33.427 1.00 17.31 ? 49  GLY   B CA   1 
ATOM   3002 C  C    . GLY   B 1 69  ? -20.466 9.109  34.337 1.00 14.91 ? 49  GLY   B C    1 
ATOM   3003 O  O    . GLY   B 1 69  ? -20.552 9.051  35.562 1.00 19.39 ? 49  GLY   B O    1 
ATOM   3004 H  H    . GLY   B 1 69  ? -23.472 8.768  34.184 1.00 21.02 ? 49  GLY   B H    1 
ATOM   3005 H  HA2  . GLY   B 1 69  ? -21.401 8.521  32.621 1.00 20.79 ? 49  GLY   B HA2  1 
ATOM   3006 H  HA3  . GLY   B 1 69  ? -21.959 9.882  33.180 1.00 20.79 ? 49  GLY   B HA3  1 
ATOM   3007 N  N    . VAL   B 1 70  ? -19.315 9.290  33.699 1.00 13.71 ? 50  VAL   B N    1 
ATOM   3008 C  CA   . VAL   B 1 70  ? -18.022 9.367  34.366 1.00 15.71 ? 50  VAL   B CA   1 
ATOM   3009 C  C    . VAL   B 1 70  ? -17.350 10.668 33.959 1.00 13.75 ? 50  VAL   B C    1 
ATOM   3010 O  O    . VAL   B 1 70  ? -17.412 11.069 32.792 1.00 15.03 ? 50  VAL   B O    1 
ATOM   3011 C  CB   . VAL   B 1 70  ? -17.133 8.162  33.991 1.00 18.49 ? 50  VAL   B CB   1 
ATOM   3012 C  CG1  . VAL   B 1 70  ? -15.720 8.362  34.499 1.00 23.52 ? 50  VAL   B CG1  1 
ATOM   3013 C  CG2  . VAL   B 1 70  ? -17.722 6.883  34.530 1.00 21.83 ? 50  VAL   B CG2  1 
ATOM   3014 H  H    . VAL   B 1 70  ? -19.257 9.374  32.845 1.00 16.47 ? 50  VAL   B H    1 
ATOM   3015 H  HA   . VAL   B 1 70  ? -18.150 9.371  35.327 1.00 18.87 ? 50  VAL   B HA   1 
ATOM   3016 H  HB   . VAL   B 1 70  ? -17.095 8.089  33.025 1.00 22.20 ? 50  VAL   B HB   1 
ATOM   3017 H  HG11 . VAL   B 1 70  ? -15.265 7.505  34.505 1.00 28.25 ? 50  VAL   B HG11 1 
ATOM   3018 H  HG12 . VAL   B 1 70  ? -15.254 8.978  33.912 1.00 28.25 ? 50  VAL   B HG12 1 
ATOM   3019 H  HG13 . VAL   B 1 70  ? -15.756 8.722  35.399 1.00 28.25 ? 50  VAL   B HG13 1 
ATOM   3020 H  HG21 . VAL   B 1 70  ? -17.154 6.141  34.271 1.00 26.21 ? 50  VAL   B HG21 1 
ATOM   3021 H  HG22 . VAL   B 1 70  ? -17.770 6.941  35.497 1.00 26.21 ? 50  VAL   B HG22 1 
ATOM   3022 H  HG23 . VAL   B 1 70  ? -18.611 6.764  34.160 1.00 26.21 ? 50  VAL   B HG23 1 
ATOM   3023 N  N    . GLY   B 1 71  ? -16.716 11.335 34.919 1.00 10.83 ? 51  GLY   B N    1 
ATOM   3024 C  CA   . GLY   B 1 71  ? -15.890 12.484 34.613 1.00 14.02 ? 51  GLY   B CA   1 
ATOM   3025 C  C    . GLY   B 1 71  ? -14.655 12.461 35.487 1.00 19.25 ? 51  GLY   B C    1 
ATOM   3026 O  O    . GLY   B 1 71  ? -14.609 11.760 36.497 1.00 21.98 ? 51  GLY   B O    1 
ATOM   3027 H  H    . GLY   B 1 71  ? -16.751 11.138 35.755 1.00 13.01 ? 51  GLY   B H    1 
ATOM   3028 H  HA2  . GLY   B 1 71  ? -15.628 12.464 33.684 1.00 16.84 ? 51  GLY   B HA2  1 
ATOM   3029 H  HA3  . GLY   B 1 71  ? -16.383 13.302 34.785 1.00 16.84 ? 51  GLY   B HA3  1 
ATOM   3030 N  N    . GLY   B 1 72  ? -13.644 13.221 35.093 1.00 13.76 ? 52  GLY   B N    1 
ATOM   3031 C  CA   . GLY   B 1 72  ? -12.530 13.400 35.999 1.00 12.10 ? 52  GLY   B CA   1 
ATOM   3032 C  C    . GLY   B 1 72  ? -11.249 13.812 35.303 1.00 14.87 ? 52  GLY   B C    1 
ATOM   3033 O  O    . GLY   B 1 72  ? -11.247 14.216 34.144 1.00 14.20 ? 52  GLY   B O    1 
ATOM   3034 H  H    . GLY   B 1 72  ? -13.581 13.628 34.338 1.00 16.52 ? 52  GLY   B H    1 
ATOM   3035 H  HA2  . GLY   B 1 72  ? -12.760 14.080 36.645 1.00 14.53 ? 52  GLY   B HA2  1 
ATOM   3036 H  HA3  . GLY   B 1 72  ? -12.362 12.571 36.474 1.00 14.53 ? 52  GLY   B HA3  1 
ATOM   3037 N  N    . LEU   B 1 73  ? -10.159 13.683 36.055 1.00 11.04 ? 53  LEU   B N    1 
ATOM   3038 C  CA   . LEU   B 1 73  ? -8.837  14.149 35.653 1.00 11.06 ? 53  LEU   B CA   1 
ATOM   3039 C  C    . LEU   B 1 73  ? -7.969  12.956 35.294 1.00 16.16 ? 53  LEU   B C    1 
ATOM   3040 O  O    . LEU   B 1 73  ? -7.689  12.107 36.147 1.00 13.10 ? 53  LEU   B O    1 
ATOM   3041 C  CB   . LEU   B 1 73  ? -8.198  14.955 36.779 1.00 12.18 ? 53  LEU   B CB   1 
ATOM   3042 C  CG   . LEU   B 1 73  ? -6.732  15.342 36.613 1.00 11.57 ? 53  LEU   B CG   1 
ATOM   3043 C  CD1  . LEU   B 1 73  ? -6.598  16.309 35.467 1.00 10.95 ? 53  LEU   B CD1  1 
ATOM   3044 C  CD2  . LEU   B 1 73  ? -6.188  15.948 37.887 1.00 13.46 ? 53  LEU   B CD2  1 
ATOM   3045 H  H    . LEU   B 1 73  ? -10.163 13.314 36.832 1.00 13.26 ? 53  LEU   B H    1 
ATOM   3046 H  HA   . LEU   B 1 73  ? -8.918  14.718 34.872 1.00 13.29 ? 53  LEU   B HA   1 
ATOM   3047 H  HB2  . LEU   B 1 73  ? -8.700  15.778 36.882 1.00 14.64 ? 53  LEU   B HB2  1 
ATOM   3048 H  HB3  . LEU   B 1 73  ? -8.265  14.436 37.596 1.00 14.64 ? 53  LEU   B HB3  1 
ATOM   3049 H  HG   . LEU   B 1 73  ? -6.206  14.554 36.409 1.00 13.90 ? 53  LEU   B HG   1 
ATOM   3050 H  HD11 . LEU   B 1 73  ? -5.657  16.448 35.281 1.00 13.16 ? 53  LEU   B HD11 1 
ATOM   3051 H  HD12 . LEU   B 1 73  ? -7.034  15.938 34.685 1.00 13.16 ? 53  LEU   B HD12 1 
ATOM   3052 H  HD13 . LEU   B 1 73  ? -7.017  17.149 35.712 1.00 13.16 ? 53  LEU   B HD13 1 
ATOM   3053 H  HD21 . LEU   B 1 73  ? -5.240  16.117 37.776 1.00 16.17 ? 53  LEU   B HD21 1 
ATOM   3054 H  HD22 . LEU   B 1 73  ? -6.655  16.780 38.065 1.00 16.17 ? 53  LEU   B HD22 1 
ATOM   3055 H  HD23 . LEU   B 1 73  ? -6.329  15.325 38.617 1.00 16.17 ? 53  LEU   B HD23 1 
ATOM   3056 N  N    . TRP   B 1 74  ? -7.518  12.906 34.046 1.00 13.75 ? 54  TRP   B N    1 
ATOM   3057 C  CA   . TRP   B 1 74  ? -6.793  11.738 33.575 1.00 13.19 ? 54  TRP   B CA   1 
ATOM   3058 C  C    . TRP   B 1 74  ? -5.285  11.852 33.756 1.00 17.24 ? 54  TRP   B C    1 
ATOM   3059 O  O    . TRP   B 1 74  ? -4.577  10.861 33.551 1.00 21.19 ? 54  TRP   B O    1 
ATOM   3060 C  CB   . TRP   B 1 74  ? -7.145  11.478 32.100 1.00 14.45 ? 54  TRP   B CB   1 
ATOM   3061 C  CG   . TRP   B 1 74  ? -8.032  10.280 31.954 1.00 13.06 ? 54  TRP   B CG   1 
ATOM   3062 C  CD1  . TRP   B 1 74  ? -7.748  9.131  31.284 1.00 18.17 ? 54  TRP   B CD1  1 
ATOM   3063 C  CD2  . TRP   B 1 74  ? -9.336  10.096 32.532 1.00 11.08 ? 54  TRP   B CD2  1 
ATOM   3064 N  NE1  . TRP   B 1 74  ? -8.787  8.244  31.403 1.00 19.21 ? 54  TRP   B NE1  1 
ATOM   3065 C  CE2  . TRP   B 1 74  ? -9.778  8.814  32.156 1.00 14.27 ? 54  TRP   B CE2  1 
ATOM   3066 C  CE3  . TRP   B 1 74  ? -10.173 10.896 33.315 1.00 14.85 ? 54  TRP   B CE3  1 
ATOM   3067 C  CZ2  . TRP   B 1 74  ? -11.016 8.308  32.540 1.00 16.90 ? 54  TRP   B CZ2  1 
ATOM   3068 C  CZ3  . TRP   B 1 74  ? -11.403 10.387 33.704 1.00 16.59 ? 54  TRP   B CZ3  1 
ATOM   3069 C  CH2  . TRP   B 1 74  ? -11.813 9.107  33.315 1.00 14.30 ? 54  TRP   B CH2  1 
ATOM   3070 H  H    . TRP   B 1 74  ? -7.617  13.528 33.461 1.00 16.52 ? 54  TRP   B H    1 
ATOM   3071 H  HA   . TRP   B 1 74  ? -7.088  10.967 34.083 1.00 15.84 ? 54  TRP   B HA   1 
ATOM   3072 H  HB2  . TRP   B 1 74  ? -7.612  12.248 31.741 1.00 17.35 ? 54  TRP   B HB2  1 
ATOM   3073 H  HB3  . TRP   B 1 74  ? -6.330  11.316 31.600 1.00 17.35 ? 54  TRP   B HB3  1 
ATOM   3074 H  HD1  . TRP   B 1 74  ? -6.958  8.966  30.822 1.00 21.83 ? 54  TRP   B HD1  1 
ATOM   3075 H  HE1  . TRP   B 1 74  ? -8.817  7.461  31.049 1.00 23.07 ? 54  TRP   B HE1  1 
ATOM   3076 H  HE3  . TRP   B 1 74  ? -9.904  11.745 33.583 1.00 17.83 ? 54  TRP   B HE3  1 
ATOM   3077 H  HZ2  . TRP   B 1 74  ? -11.291 7.458  32.282 1.00 20.30 ? 54  TRP   B HZ2  1 
ATOM   3078 H  HZ3  . TRP   B 1 74  ? -11.969 10.909 34.226 1.00 19.93 ? 54  TRP   B HZ3  1 
ATOM   3079 H  HH2  . TRP   B 1 74  ? -12.648 8.795  33.582 1.00 17.18 ? 54  TRP   B HH2  1 
ATOM   3080 N  N    . THR   B 1 75  ? -4.781  13.013 34.159 1.00 12.92 ? 55  THR   B N    1 
ATOM   3081 C  CA   . THR   B 1 75  ? -3.343  13.262 34.247 1.00 13.82 ? 55  THR   B CA   1 
ATOM   3082 C  C    . THR   B 1 75  ? -3.023  13.725 35.664 1.00 13.64 ? 55  THR   B C    1 
ATOM   3083 O  O    . THR   B 1 75  ? -3.286  14.878 36.019 1.00 13.69 ? 55  THR   B O    1 
ATOM   3084 C  CB   . THR   B 1 75  ? -2.918  14.304 33.212 1.00 13.33 ? 55  THR   B CB   1 
ATOM   3085 O  OG1  . THR   B 1 75  ? -3.769  15.451 33.336 1.00 13.48 ? 55  THR   B OG1  1 
ATOM   3086 C  CG2  . THR   B 1 75  ? -3.035  13.763 31.806 1.00 14.77 ? 55  THR   B CG2  1 
ATOM   3087 H  H    . THR   B 1 75  ? -5.260  13.688 34.393 1.00 15.53 ? 55  THR   B H    1 
ATOM   3088 H  HA   . THR   B 1 75  ? -2.856  12.441 34.075 1.00 16.60 ? 55  THR   B HA   1 
ATOM   3089 H  HB   . THR   B 1 75  ? -1.997  14.563 33.369 1.00 16.01 ? 55  THR   B HB   1 
ATOM   3090 H  HG1  . THR   B 1 75  ? -3.697  15.781 34.105 1.00 16.19 ? 55  THR   B HG1  1 
ATOM   3091 H  HG21 . THR   B 1 75  ? -2.759  14.439 31.167 1.00 17.74 ? 55  THR   B HG21 1 
ATOM   3092 H  HG22 . THR   B 1 75  ? -2.469  12.982 31.703 1.00 17.74 ? 55  THR   B HG22 1 
ATOM   3093 H  HG23 . THR   B 1 75  ? -3.954  13.513 31.623 1.00 17.74 ? 55  THR   B HG23 1 
ATOM   3094 N  N    . THR   B 1 76  ? -2.459  12.822 36.462 1.00 13.38 ? 56  THR   B N    1 
ATOM   3095 C  CA   . THR   B 1 76  ? -2.156  13.082 37.857 1.00 12.18 ? 56  THR   B CA   1 
ATOM   3096 C  C    . THR   B 1 76  ? -0.741  12.618 38.179 1.00 12.24 ? 56  THR   B C    1 
ATOM   3097 O  O    . THR   B 1 76  ? -0.072  11.969 37.369 1.00 15.95 ? 56  THR   B O    1 
ATOM   3098 C  CB   . THR   B 1 76  ? -3.118  12.351 38.799 1.00 18.26 ? 56  THR   B CB   1 
ATOM   3099 O  OG1  . THR   B 1 76  ? -2.826  10.946 38.747 1.00 20.68 ? 56  THR   B OG1  1 
ATOM   3100 C  CG2  . THR   B 1 76  ? -4.556  12.579 38.399 1.00 18.08 ? 56  THR   B CG2  1 
ATOM   3101 H  H    . THR   B 1 76  ? -2.238  12.031 36.206 1.00 16.07 ? 56  THR   B H    1 
ATOM   3102 H  HA   . THR   B 1 76  ? -2.216  14.034 38.033 1.00 14.63 ? 56  THR   B HA   1 
ATOM   3103 H  HB   . THR   B 1 76  ? -2.994  12.675 39.705 1.00 21.93 ? 56  THR   B HB   1 
ATOM   3104 H  HG1  . THR   B 1 76  ? -3.381  10.521 39.213 1.00 24.84 ? 56  THR   B HG1  1 
ATOM   3105 H  HG21 . THR   B 1 76  ? -5.144  12.342 39.131 1.00 21.72 ? 56  THR   B HG21 1 
ATOM   3106 H  HG22 . THR   B 1 76  ? -4.692  13.513 38.176 1.00 21.72 ? 56  THR   B HG22 1 
ATOM   3107 H  HG23 . THR   B 1 76  ? -4.776  12.036 37.626 1.00 21.72 ? 56  THR   B HG23 1 
ATOM   3108 N  N    . ASP   B 1 77  ? -0.306  12.906 39.412 1.00 14.92 ? 57  ASP   B N    1 
ATOM   3109 C  CA   . ASP   B 1 77  ? 1.051   12.521 39.793 1.00 18.96 ? 57  ASP   B CA   1 
ATOM   3110 C  C    . ASP   B 1 77  ? 1.197   11.005 39.886 1.00 18.52 ? 57  ASP   B C    1 
ATOM   3111 O  O    . ASP   B 1 77  ? 2.297   10.480 39.679 1.00 21.83 ? 57  ASP   B O    1 
ATOM   3112 C  CB   . ASP   B 1 77  ? 1.471   13.188 41.111 1.00 14.90 ? 57  ASP   B CB   1 
ATOM   3113 C  CG   . ASP   B 1 77  ? 0.713   12.672 42.329 1.00 24.47 ? 57  ASP   B CG   1 
ATOM   3114 O  OD1  . ASP   B 1 77  ? 0.973   11.537 42.786 1.00 28.49 ? 57  ASP   B OD1  1 
ATOM   3115 O  OD2  . ASP   B 1 77  ? -0.118  13.436 42.866 1.00 22.31 ? 57  ASP   B OD2  1 
ATOM   3116 H  H    . ASP   B 1 77  ? -0.760  13.308 40.022 1.00 17.92 ? 57  ASP   B H    1 
ATOM   3117 H  HA   . ASP   B 1 77  ? 1.661   12.825 39.107 1.00 22.77 ? 57  ASP   B HA   1 
ATOM   3118 H  HB2  . ASP   B 1 77  ? 2.416   13.023 41.258 1.00 17.90 ? 57  ASP   B HB2  1 
ATOM   3119 H  HB3  . ASP   B 1 77  ? 1.310   14.142 41.044 1.00 17.90 ? 57  ASP   B HB3  1 
ATOM   3120 N  N    . SER   B 1 78  ? 0.109   10.284 40.162 1.00 18.47 ? 58  SER   B N    1 
ATOM   3121 C  CA   . SER   B 1 78  ? 0.199   8.836  40.312 1.00 23.44 ? 58  SER   B CA   1 
ATOM   3122 C  C    . SER   B 1 78  ? 0.281   8.108  38.975 1.00 28.36 ? 58  SER   B C    1 
ATOM   3123 O  O    . SER   B 1 78  ? 0.784   6.982  38.928 1.00 30.81 ? 58  SER   B O    1 
ATOM   3124 C  CB   . SER   B 1 78  ? -1.000  8.316  41.111 1.00 24.27 ? 58  SER   B CB   1 
ATOM   3125 O  OG   . SER   B 1 78  ? -2.191  8.349  40.347 1.00 28.05 ? 58  SER   B OG   1 
ATOM   3126 H  H    . SER   B 1 78  ? -0.682  10.606 40.266 1.00 22.18 ? 58  SER   B H    1 
ATOM   3127 H  HA   . SER   B 1 78  ? 1.002   8.624  40.813 1.00 28.15 ? 58  SER   B HA   1 
ATOM   3128 H  HB2  . SER   B 1 78  ? -0.825  7.400  41.378 1.00 29.14 ? 58  SER   B HB2  1 
ATOM   3129 H  HB3  . SER   B 1 78  ? -1.117  8.872  41.897 1.00 29.14 ? 58  SER   B HB3  1 
ATOM   3130 H  HG   . SER   B 1 78  ? -2.358  9.137  40.110 1.00 33.67 ? 58  SER   B HG   1 
ATOM   3131 N  N    . GLY   B 1 79  ? -0.171  8.728  37.891 1.00 19.79 ? 59  GLY   B N    1 
ATOM   3132 C  CA   . GLY   B 1 79  ? -0.306  8.052  36.622 1.00 22.97 ? 59  GLY   B CA   1 
ATOM   3133 C  C    . GLY   B 1 79  ? -1.660  7.420  36.407 1.00 25.18 ? 59  GLY   B C    1 
ATOM   3134 O  O    . GLY   B 1 79  ? -1.945  6.951  35.298 1.00 27.92 ? 59  GLY   B O    1 
ATOM   3135 H  H    . GLY   B 1 79  ? -0.409  9.554  37.871 1.00 23.76 ? 59  GLY   B H    1 
ATOM   3136 H  HA2  . GLY   B 1 79  ? -0.153  8.688  35.906 1.00 27.58 ? 59  GLY   B HA2  1 
ATOM   3137 H  HA3  . GLY   B 1 79  ? 0.367   7.356  36.556 1.00 27.58 ? 59  GLY   B HA3  1 
ATOM   3138 N  N    . GLN   B 1 80  ? -2.494  7.399  37.419 0.92 22.20 ? 60  GLN   B N    1 
ATOM   3139 C  CA   . GLN   B 1 80  ? -3.840  6.869  37.343 0.92 27.08 ? 60  GLN   B CA   1 
ATOM   3140 C  C    . GLN   B 1 80  ? -4.853  8.002  37.333 0.92 21.50 ? 60  GLN   B C    1 
ATOM   3141 O  O    . GLN   B 1 80  ? -4.690  8.982  38.068 0.92 18.46 ? 60  GLN   B O    1 
ATOM   3142 C  CB   . GLN   B 1 80  ? -4.123  5.947  38.533 0.92 26.13 ? 60  GLN   B CB   1 
ATOM   3143 C  CG   . GLN   B 1 80  ? -3.493  4.575  38.402 0.92 39.31 ? 60  GLN   B CG   1 
ATOM   3144 C  CD   . GLN   B 1 80  ? -4.179  3.728  37.348 0.92 48.44 ? 60  GLN   B CD   1 
ATOM   3145 O  OE1  . GLN   B 1 80  ? -5.374  3.447  37.444 0.92 65.42 ? 60  GLN   B OE1  1 
ATOM   3146 N  NE2  . GLN   B 1 80  ? -3.427  3.324  36.329 0.92 60.02 ? 60  GLN   B NE2  1 
ATOM   3147 H  H    . GLN   B 1 80  ? -2.297  7.699  38.200 0.92 26.66 ? 60  GLN   B H    1 
ATOM   3148 H  HA   . GLN   B 1 80  ? -3.920  6.346  36.534 0.92 32.52 ? 60  GLN   B HA   1 
ATOM   3149 H  HB2  . GLN   B 1 80  ? -3.773  6.359  39.338 0.92 31.37 ? 60  GLN   B HB2  1 
ATOM   3150 H  HB3  . GLN   B 1 80  ? -5.082  5.827  38.615 0.92 31.37 ? 60  GLN   B HB3  1 
ATOM   3151 H  HG2  . GLN   B 1 80  ? -2.562  4.676  38.150 0.92 47.18 ? 60  GLN   B HG2  1 
ATOM   3152 H  HG3  . GLN   B 1 80  ? -3.560  4.112  39.252 0.92 47.18 ? 60  GLN   B HG3  1 
ATOM   3153 H  HE21 . GLN   B 1 80  ? -2.596  3.541  36.295 0.92 72.04 ? 60  GLN   B HE21 1 
ATOM   3154 H  HE22 . GLN   B 1 80  ? -3.771  2.842  35.705 0.92 72.04 ? 60  GLN   B HE22 1 
ATOM   3155 N  N    . PRO   B 1 81  ? -5.900  7.903  36.518 1.00 17.37 ? 61  PRO   B N    1 
ATOM   3156 C  CA   . PRO   B 1 81  ? -6.934  8.941  36.537 1.00 16.47 ? 61  PRO   B CA   1 
ATOM   3157 C  C    . PRO   B 1 81  ? -7.599  9.045  37.899 1.00 20.00 ? 61  PRO   B C    1 
ATOM   3158 O  O    . PRO   B 1 81  ? -7.676  8.078  38.661 1.00 19.63 ? 61  PRO   B O    1 
ATOM   3159 C  CB   . PRO   B 1 81  ? -7.936  8.471  35.473 1.00 16.35 ? 61  PRO   B CB   1 
ATOM   3160 C  CG   . PRO   B 1 81  ? -7.131  7.585  34.556 1.00 27.25 ? 61  PRO   B CG   1 
ATOM   3161 C  CD   . PRO   B 1 81  ? -6.148  6.890  35.471 1.00 21.41 ? 61  PRO   B CD   1 
ATOM   3162 H  HA   . PRO   B 1 81  ? -6.564  9.801  36.283 1.00 19.78 ? 61  PRO   B HA   1 
ATOM   3163 H  HB2  . PRO   B 1 81  ? -8.651  7.970  35.895 1.00 19.64 ? 61  PRO   B HB2  1 
ATOM   3164 H  HB3  . PRO   B 1 81  ? -8.288  9.236  34.993 1.00 19.64 ? 61  PRO   B HB3  1 
ATOM   3165 H  HG2  . PRO   B 1 81  ? -7.715  6.942  34.124 1.00 32.72 ? 61  PRO   B HG2  1 
ATOM   3166 H  HG3  . PRO   B 1 81  ? -6.667  8.127  33.899 1.00 32.72 ? 61  PRO   B HG3  1 
ATOM   3167 H  HD2  . PRO   B 1 81  ? -6.545  6.092  35.855 1.00 25.71 ? 61  PRO   B HD2  1 
ATOM   3168 H  HD3  . PRO   B 1 81  ? -5.334  6.688  34.985 1.00 25.71 ? 61  PRO   B HD3  1 
ATOM   3169 N  N    . ILE   B 1 82  ? -8.099  10.237 38.198 1.00 14.66 ? 62  ILE   B N    1 
ATOM   3170 C  CA   . ILE   B 1 82  ? -9.031  10.441 39.295 1.00 14.24 ? 62  ILE   B CA   1 
ATOM   3171 C  C    . ILE   B 1 82  ? -10.404 10.560 38.648 1.00 21.94 ? 62  ILE   B C    1 
ATOM   3172 O  O    . ILE   B 1 82  ? -10.780 11.629 38.158 1.00 18.37 ? 62  ILE   B O    1 
ATOM   3173 C  CB   . ILE   B 1 82  ? -8.663  11.662 40.147 1.00 18.78 ? 62  ILE   B CB   1 
ATOM   3174 C  CG1  . ILE   B 1 82  ? -7.302  11.418 40.803 1.00 17.28 ? 62  ILE   B CG1  1 
ATOM   3175 C  CG2  . ILE   B 1 82  ? -9.733  11.909 41.203 1.00 22.22 ? 62  ILE   B CG2  1 
ATOM   3176 C  CD1  . ILE   B 1 82  ? -6.729  12.617 41.516 1.00 21.57 ? 62  ILE   B CD1  1 
ATOM   3177 H  H    . ILE   B 1 82  ? -7.908  10.958 37.770 1.00 17.61 ? 62  ILE   B H    1 
ATOM   3178 H  HA   . ILE   B 1 82  ? -9.032  9.660  39.870 1.00 17.11 ? 62  ILE   B HA   1 
ATOM   3179 H  HB   . ILE   B 1 82  ? -8.601  12.441 39.572 1.00 22.56 ? 62  ILE   B HB   1 
ATOM   3180 H  HG12 . ILE   B 1 82  ? -7.398  10.708 41.457 1.00 20.75 ? 62  ILE   B HG12 1 
ATOM   3181 H  HG13 . ILE   B 1 82  ? -6.669  11.147 40.121 1.00 20.75 ? 62  ILE   B HG13 1 
ATOM   3182 H  HG21 . ILE   B 1 82  ? -9.436  12.615 41.798 1.00 26.68 ? 62  ILE   B HG21 1 
ATOM   3183 H  HG22 . ILE   B 1 82  ? -10.557 12.176 40.766 1.00 26.68 ? 62  ILE   B HG22 1 
ATOM   3184 H  HG23 . ILE   B 1 82  ? -9.874  11.091 41.706 1.00 26.68 ? 62  ILE   B HG23 1 
ATOM   3185 H  HD11 . ILE   B 1 82  ? -5.810  12.427 41.763 1.00 25.90 ? 62  ILE   B HD11 1 
ATOM   3186 H  HD12 . ILE   B 1 82  ? -6.760  13.382 40.921 1.00 25.90 ? 62  ILE   B HD12 1 
ATOM   3187 H  HD13 . ILE   B 1 82  ? -7.255  12.795 42.311 1.00 25.90 ? 62  ILE   B HD13 1 
ATOM   3188 N  N    . ALA   B 1 83  ? -11.123 9.447  38.594 1.00 18.76 ? 63  ALA   B N    1 
ATOM   3189 C  CA   . ALA   B 1 83  ? -12.389 9.359  37.884 1.00 19.70 ? 63  ALA   B CA   1 
ATOM   3190 C  C    . ALA   B 1 83  ? -13.535 9.382  38.884 1.00 23.08 ? 63  ALA   B C    1 
ATOM   3191 O  O    . ALA   B 1 83  ? -13.475 8.727  39.928 1.00 20.29 ? 63  ALA   B O    1 
ATOM   3192 C  CB   . ALA   B 1 83  ? -12.458 8.085  37.039 1.00 24.44 ? 63  ALA   B CB   1 
ATOM   3193 H  H    . ALA   B 1 83  ? -10.891 8.710  38.972 1.00 22.52 ? 63  ALA   B H    1 
ATOM   3194 H  HA   . ALA   B 1 83  ? -12.483 10.122 37.293 1.00 23.66 ? 63  ALA   B HA   1 
ATOM   3195 H  HB1  . ALA   B 1 83  ? -13.312 8.057  36.580 1.00 29.34 ? 63  ALA   B HB1  1 
ATOM   3196 H  HB2  . ALA   B 1 83  ? -11.735 8.096  36.393 1.00 29.34 ? 63  ALA   B HB2  1 
ATOM   3197 H  HB3  . ALA   B 1 83  ? -12.370 7.315  37.622 1.00 29.34 ? 63  ALA   B HB3  1 
ATOM   3198 N  N    . ILE   B 1 84  ? -14.576 10.140 38.560 1.00 15.38 ? 64  ILE   B N    1 
ATOM   3199 C  CA   . ILE   B 1 84  ? -15.780 10.230 39.376 1.00 16.75 ? 64  ILE   B CA   1 
ATOM   3200 C  C    . ILE   B 1 84  ? -16.878 9.488  38.629 1.00 16.35 ? 64  ILE   B C    1 
ATOM   3201 O  O    . ILE   B 1 84  ? -17.217 9.857  37.499 1.00 16.67 ? 64  ILE   B O    1 
ATOM   3202 C  CB   . ILE   B 1 84  ? -16.178 11.692 39.633 1.00 22.51 ? 64  ILE   B CB   1 
ATOM   3203 C  CG1  . ILE   B 1 84  ? -14.946 12.540 39.958 1.00 32.61 ? 64  ILE   B CG1  1 
ATOM   3204 C  CG2  . ILE   B 1 84  ? -17.225 11.754 40.729 1.00 22.36 ? 64  ILE   B CG2  1 
ATOM   3205 C  CD1  . ILE   B 1 84  ? -14.180 12.089 41.161 1.00 34.89 ? 64  ILE   B CD1  1 
ATOM   3206 H  H    . ILE   B 1 84  ? -14.609 10.625 37.851 1.00 18.48 ? 64  ILE   B H    1 
ATOM   3207 H  HA   . ILE   B 1 84  ? -15.634 9.793  40.229 1.00 20.12 ? 64  ILE   B HA   1 
ATOM   3208 H  HB   . ILE   B 1 84  ? -16.574 12.040 38.820 1.00 27.03 ? 64  ILE   B HB   1 
ATOM   3209 H  HG12 . ILE   B 1 84  ? -14.342 12.529 39.199 1.00 39.15 ? 64  ILE   B HG12 1 
ATOM   3210 H  HG13 . ILE   B 1 84  ? -15.237 13.450 40.125 1.00 39.15 ? 64  ILE   B HG13 1 
ATOM   3211 H  HG21 . ILE   B 1 84  ? -17.409 12.684 40.936 1.00 26.86 ? 64  ILE   B HG21 1 
ATOM   3212 H  HG22 . ILE   B 1 84  ? -18.034 11.318 40.418 1.00 26.86 ? 64  ILE   B HG22 1 
ATOM   3213 H  HG23 . ILE   B 1 84  ? -16.886 11.301 41.517 1.00 26.86 ? 64  ILE   B HG23 1 
ATOM   3214 H  HD11 . ILE   B 1 84  ? -13.439 12.698 41.308 1.00 41.89 ? 64  ILE   B HD11 1 
ATOM   3215 H  HD12 . ILE   B 1 84  ? -14.768 12.094 41.932 1.00 41.89 ? 64  ILE   B HD12 1 
ATOM   3216 H  HD13 . ILE   B 1 84  ? -13.844 11.193 41.007 1.00 41.89 ? 64  ILE   B HD13 1 
ATOM   3217 N  N    . ARG   B 1 85  ? -17.451 8.460  39.253 1.00 19.20 ? 65  ARG   B N    1 
ATOM   3218 C  CA   . ARG   B 1 85  ? -18.335 7.527  38.551 1.00 16.82 ? 65  ARG   B CA   1 
ATOM   3219 C  C    . ARG   B 1 85  ? -19.773 7.696  39.012 1.00 24.83 ? 65  ARG   B C    1 
ATOM   3220 O  O    . ARG   B 1 85  ? -20.110 7.409  40.167 1.00 19.88 ? 65  ARG   B O    1 
ATOM   3221 C  CB   . ARG   B 1 85  ? -17.857 6.091  38.753 1.00 24.74 ? 65  ARG   B CB   1 
ATOM   3222 C  CG   . ARG   B 1 85  ? -16.455 5.866  38.208 1.00 36.99 ? 65  ARG   B CG   1 
ATOM   3223 C  CD   . ARG   B 1 85  ? -15.929 4.452  38.412 1.00 46.85 ? 65  ARG   B CD   1 
ATOM   3224 N  NE   . ARG   B 1 85  ? -14.564 4.337  37.906 1.00 46.56 ? 65  ARG   B NE   1 
ATOM   3225 C  CZ   . ARG   B 1 85  ? -14.247 4.183  36.626 1.00 57.25 ? 65  ARG   B CZ   1 
ATOM   3226 N  NH1  . ARG   B 1 85  ? -15.178 4.073  35.692 1.00 48.77 ? 65  ARG   B NH1  1 
ATOM   3227 N  NH2  . ARG   B 1 85  ? -12.965 4.144  36.275 1.00 58.43 ? 65  ARG   B NH2  1 
ATOM   3228 H  H    . ARG   B 1 85  ? -17.344 8.279  40.087 1.00 23.05 ? 65  ARG   B H    1 
ATOM   3229 H  HA   . ARG   B 1 85  ? -18.305 7.717  37.601 1.00 20.20 ? 65  ARG   B HA   1 
ATOM   3230 H  HB2  . ARG   B 1 85  ? -17.847 5.890  39.702 1.00 29.71 ? 65  ARG   B HB2  1 
ATOM   3231 H  HB3  . ARG   B 1 85  ? -18.460 5.488  38.291 1.00 29.71 ? 65  ARG   B HB3  1 
ATOM   3232 H  HG2  . ARG   B 1 85  ? -16.459 6.045  37.255 1.00 44.40 ? 65  ARG   B HG2  1 
ATOM   3233 H  HG3  . ARG   B 1 85  ? -15.845 6.474  38.654 1.00 44.40 ? 65  ARG   B HG3  1 
ATOM   3234 H  HD2  . ARG   B 1 85  ? -15.922 4.245  39.360 1.00 56.24 ? 65  ARG   B HD2  1 
ATOM   3235 H  HD3  . ARG   B 1 85  ? -16.492 3.824  37.933 1.00 56.24 ? 65  ARG   B HD3  1 
ATOM   3236 H  HE   . ARG   B 1 85  ? -13.921 4.371  38.476 1.00 55.89 ? 65  ARG   B HE   1 
ATOM   3237 H  HH11 . ARG   B 1 85  ? -16.010 4.100  35.905 1.00 58.54 ? 65  ARG   B HH11 1 
ATOM   3238 H  HH12 . ARG   B 1 85  ? -14.949 3.974  34.869 1.00 58.54 ? 65  ARG   B HH12 1 
ATOM   3239 H  HH21 . ARG   B 1 85  ? -12.353 4.214  36.875 1.00 70.13 ? 65  ARG   B HH21 1 
ATOM   3240 H  HH22 . ARG   B 1 85  ? -12.748 4.042  35.449 1.00 70.13 ? 65  ARG   B HH22 1 
ATOM   3241 N  N    . GLY   B 1 86  ? -20.622 8.128  38.101 1.00 24.63 ? 66  GLY   B N    1 
ATOM   3242 C  CA   . GLY   B 1 86  ? -22.037 8.195  38.403 1.00 22.38 ? 66  GLY   B CA   1 
ATOM   3243 C  C    . GLY   B 1 86  ? -22.474 9.631  38.603 1.00 23.80 ? 66  GLY   B C    1 
ATOM   3244 O  O    . GLY   B 1 86  ? -21.772 10.442 39.217 1.00 20.73 ? 66  GLY   B O    1 
ATOM   3245 H  H    . GLY   B 1 86  ? -20.409 8.386  37.309 1.00 29.57 ? 66  GLY   B H    1 
ATOM   3246 H  HA2  . GLY   B 1 86  ? -22.543 7.819  37.666 1.00 26.88 ? 66  GLY   B HA2  1 
ATOM   3247 H  HA3  . GLY   B 1 86  ? -22.235 7.687  39.203 1.00 26.88 ? 66  GLY   B HA3  1 
ATOM   3248 N  N    A ARG   B 1 87  ? -23.657 9.949  38.086 0.52 23.02 ? 67  ARG   B N    1 
ATOM   3249 N  N    B ARG   B 1 87  ? -23.661 9.949  38.086 0.48 23.02 ? 67  ARG   B N    1 
ATOM   3250 C  CA   A ARG   B 1 87  ? -24.134 11.324 38.136 0.52 25.35 ? 67  ARG   B CA   1 
ATOM   3251 C  CA   B ARG   B 1 87  ? -24.146 11.322 38.129 0.48 25.35 ? 67  ARG   B CA   1 
ATOM   3252 C  C    A ARG   B 1 87  ? -24.192 11.839 39.569 0.52 25.27 ? 67  ARG   B C    1 
ATOM   3253 C  C    B ARG   B 1 87  ? -24.239 11.845 39.556 0.48 25.26 ? 67  ARG   B C    1 
ATOM   3254 O  O    A ARG   B 1 87  ? -23.884 13.008 39.826 0.52 27.26 ? 67  ARG   B O    1 
ATOM   3255 O  O    B ARG   B 1 87  ? -23.993 13.032 39.794 0.48 27.24 ? 67  ARG   B O    1 
ATOM   3256 C  CB   A ARG   B 1 87  ? -25.503 11.407 37.467 0.52 21.02 ? 67  ARG   B CB   1 
ATOM   3257 C  CB   B ARG   B 1 87  ? -25.500 11.395 37.426 0.48 20.97 ? 67  ARG   B CB   1 
ATOM   3258 C  CG   A ARG   B 1 87  ? -25.989 12.811 37.265 0.52 22.67 ? 67  ARG   B CG   1 
ATOM   3259 C  CG   B ARG   B 1 87  ? -25.995 12.794 37.143 0.48 22.57 ? 67  ARG   B CG   1 
ATOM   3260 C  CD   A ARG   B 1 87  ? -27.452 12.802 36.916 0.52 23.37 ? 67  ARG   B CD   1 
ATOM   3261 C  CD   B ARG   B 1 87  ? -27.288 12.736 36.344 0.48 18.50 ? 67  ARG   B CD   1 
ATOM   3262 N  NE   A ARG   B 1 87  ? -27.689 13.231 35.544 0.52 23.24 ? 67  ARG   B NE   1 
ATOM   3263 N  NE   B ARG   B 1 87  ? -28.310 11.981 37.058 0.48 28.40 ? 67  ARG   B NE   1 
ATOM   3264 C  CZ   A ARG   B 1 87  ? -28.870 13.171 34.946 0.52 24.97 ? 67  ARG   B CZ   1 
ATOM   3265 C  CZ   B ARG   B 1 87  ? -29.383 11.445 36.494 0.48 32.72 ? 67  ARG   B CZ   1 
ATOM   3266 N  NH1  A ARG   B 1 87  ? -29.928 12.669 35.563 0.52 28.41 ? 67  ARG   B NH1  1 
ATOM   3267 N  NH1  B ARG   B 1 87  ? -29.600 11.537 35.192 0.48 35.94 ? 67  ARG   B NH1  1 
ATOM   3268 N  NH2  A ARG   B 1 87  ? -28.993 13.631 33.705 0.52 13.51 ? 67  ARG   B NH2  1 
ATOM   3269 N  NH2  B ARG   B 1 87  ? -30.256 10.790 37.254 0.48 30.54 ? 67  ARG   B NH2  1 
ATOM   3270 H  H    A ARG   B 1 87  ? -24.195 9.395  37.706 0.52 27.65 ? 67  ARG   B H    1 
ATOM   3271 H  H    B ARG   B 1 87  ? -24.198 9.393  37.709 0.48 27.64 ? 67  ARG   B H    1 
ATOM   3272 H  HA   A ARG   B 1 87  ? -23.522 11.889 37.639 0.52 30.44 ? 67  ARG   B HA   1 
ATOM   3273 H  HA   B ARG   B 1 87  ? -23.527 11.889 37.644 0.48 30.44 ? 67  ARG   B HA   1 
ATOM   3274 H  HB2  A ARG   B 1 87  ? -25.454 10.981 36.597 0.52 25.24 ? 67  ARG   B HB2  1 
ATOM   3275 H  HB2  B ARG   B 1 87  ? -25.433 10.931 36.577 0.48 25.18 ? 67  ARG   B HB2  1 
ATOM   3276 H  HB3  A ARG   B 1 87  ? -26.146 10.943 38.026 0.52 25.24 ? 67  ARG   B HB3  1 
ATOM   3277 H  HB3  B ARG   B 1 87  ? -26.159 10.956 37.986 0.48 25.18 ? 67  ARG   B HB3  1 
ATOM   3278 H  HG2  A ARG   B 1 87  ? -25.871 13.320 38.081 0.52 27.22 ? 67  ARG   B HG2  1 
ATOM   3279 H  HG2  B ARG   B 1 87  ? -26.168 13.253 37.979 0.48 27.10 ? 67  ARG   B HG2  1 
ATOM   3280 H  HG3  A ARG   B 1 87  ? -25.499 13.220 36.535 0.52 27.22 ? 67  ARG   B HG3  1 
ATOM   3281 H  HG3  B ARG   B 1 87  ? -25.331 13.271 36.623 0.48 27.10 ? 67  ARG   B HG3  1 
ATOM   3282 H  HD2  A ARG   B 1 87  ? -27.804 11.904 37.013 0.52 28.07 ? 67  ARG   B HD2  1 
ATOM   3283 H  HD2  B ARG   B 1 87  ? -27.618 13.637 36.200 0.48 22.22 ? 67  ARG   B HD2  1 
ATOM   3284 H  HD3  A ARG   B 1 87  ? -27.923 13.410 37.507 0.52 28.07 ? 67  ARG   B HD3  1 
ATOM   3285 H  HD3  B ARG   B 1 87  ? -27.119 12.298 35.495 0.48 22.22 ? 67  ARG   B HD3  1 
ATOM   3286 H  HE   A ARG   B 1 87  ? -27.053 13.642 35.136 0.52 27.91 ? 67  ARG   B HE   1 
ATOM   3287 H  HE   B ARG   B 1 87  ? -28.210 11.876 37.906 0.48 34.10 ? 67  ARG   B HE   1 
ATOM   3288 H  HH11 A ARG   B 1 87  ? -29.861 12.371 36.367 0.52 34.10 ? 67  ARG   B HH11 1 
ATOM   3289 H  HH11 B ARG   B 1 87  ? -29.044 11.957 34.689 0.48 43.15 ? 67  ARG   B HH11 1 
ATOM   3290 H  HH12 A ARG   B 1 87  ? -30.684 12.639 35.156 0.52 34.10 ? 67  ARG   B HH12 1 
ATOM   3291 H  HH12 B ARG   B 1 87  ? -30.303 11.180 34.848 0.48 43.15 ? 67  ARG   B HH12 1 
ATOM   3292 H  HH21 A ARG   B 1 87  ? -28.310 13.958 33.298 0.52 16.23 ? 67  ARG   B HH21 1 
ATOM   3293 H  HH21 B ARG   B 1 87  ? -30.123 10.723 38.101 0.48 36.66 ? 67  ARG   B HH21 1 
ATOM   3294 H  HH22 A ARG   B 1 87  ? -29.754 13.595 33.307 0.52 16.23 ? 67  ARG   B HH22 1 
ATOM   3295 H  HH22 B ARG   B 1 87  ? -30.955 10.436 36.899 0.48 36.66 ? 67  ARG   B HH22 1 
ATOM   3296 N  N    . GLU   B 1 88  ? -24.564 10.979 40.519 1.00 30.96 ? 68  GLU   B N    1 
ATOM   3297 C  CA   . GLU   B 1 88  ? -24.708 11.436 41.899 1.00 31.37 ? 68  GLU   B CA   1 
ATOM   3298 C  C    . GLU   B 1 88  ? -23.358 11.765 42.532 1.00 31.00 ? 68  GLU   B C    1 
ATOM   3299 O  O    . GLU   B 1 88  ? -23.232 12.766 43.249 1.00 26.30 ? 68  GLU   B O    1 
ATOM   3300 C  CB   . GLU   B 1 88  ? -25.446 10.383 42.728 1.00 44.22 ? 68  GLU   B CB   1 
ATOM   3301 H  H    A GLU   B 1 88  ? -24.735 10.146 40.394 0.52 37.17 ? 68  GLU   B H    1 
ATOM   3302 H  H    B GLU   B 1 88  ? -24.704 10.139 40.401 0.48 37.17 ? 68  GLU   B H    1 
ATOM   3303 H  HA   . GLU   B 1 88  ? -25.242 12.245 41.905 1.00 37.66 ? 68  GLU   B HA   1 
ATOM   3304 N  N    . LYS   B 1 89  ? -22.343 10.928 42.294 1.00 27.08 ? 69  LYS   B N    1 
ATOM   3305 C  CA   . LYS   B 1 89  ? -21.001 11.238 42.776 1.00 23.65 ? 69  LYS   B CA   1 
ATOM   3306 C  C    . LYS   B 1 89  ? -20.417 12.466 42.084 1.00 19.43 ? 69  LYS   B C    1 
ATOM   3307 O  O    . LYS   B 1 89  ? -19.654 13.218 42.701 1.00 21.74 ? 69  LYS   B O    1 
ATOM   3308 C  CB   . LYS   B 1 89  ? -20.077 10.036 42.568 1.00 29.52 ? 69  LYS   B CB   1 
ATOM   3309 C  CG   . LYS   B 1 89  ? -20.362 8.856  43.489 1.00 41.02 ? 69  LYS   B CG   1 
ATOM   3310 H  H    . LYS   B 1 89  ? -22.407 10.187 41.863 1.00 32.52 ? 69  LYS   B H    1 
ATOM   3311 H  HA   . LYS   B 1 89  ? -21.043 11.422 43.727 1.00 28.40 ? 69  LYS   B HA   1 
ATOM   3312 H  HB2  . LYS   B 1 89  ? -20.172 9.726  41.654 1.00 35.44 ? 69  LYS   B HB2  1 
ATOM   3313 H  HB3  . LYS   B 1 89  ? -19.162 10.317 42.724 1.00 35.44 ? 69  LYS   B HB3  1 
ATOM   3314 N  N    . LEU   B 1 90  ? -20.739 12.678 40.806 1.00 20.01 ? 70  LEU   B N    1 
ATOM   3315 C  CA   . LEU   B 1 90  ? -20.299 13.904 40.150 1.00 17.28 ? 70  LEU   B CA   1 
ATOM   3316 C  C    . LEU   B 1 90  ? -20.862 15.130 40.858 1.00 17.31 ? 70  LEU   B C    1 
ATOM   3317 O  O    . LEU   B 1 90  ? -20.168 16.141 41.011 1.00 19.37 ? 70  LEU   B O    1 
ATOM   3318 C  CB   . LEU   B 1 90  ? -20.708 13.899 38.681 1.00 17.45 ? 70  LEU   B CB   1 
ATOM   3319 C  CG   . LEU   B 1 90  ? -19.876 12.984 37.779 1.00 17.52 ? 70  LEU   B CG   1 
ATOM   3320 C  CD1  . LEU   B 1 90  ? -20.606 12.725 36.476 1.00 22.09 ? 70  LEU   B CD1  1 
ATOM   3321 C  CD2  . LEU   B 1 90  ? -18.513 13.603 37.541 1.00 17.72 ? 70  LEU   B CD2  1 
ATOM   3322 H  H    . LEU   B 1 90  ? -21.197 12.144 40.312 1.00 24.03 ? 70  LEU   B H    1 
ATOM   3323 H  HA   . LEU   B 1 90  ? -19.332 13.954 40.194 1.00 20.75 ? 70  LEU   B HA   1 
ATOM   3324 H  HB2  . LEU   B 1 90  ? -21.632 13.609 38.619 1.00 20.95 ? 70  LEU   B HB2  1 
ATOM   3325 H  HB3  . LEU   B 1 90  ? -20.627 14.802 38.336 1.00 20.95 ? 70  LEU   B HB3  1 
ATOM   3326 H  HG   . LEU   B 1 90  ? -19.746 12.133 38.225 1.00 21.05 ? 70  LEU   B HG   1 
ATOM   3327 H  HD11 . LEU   B 1 90  ? -20.049 12.169 35.908 1.00 26.53 ? 70  LEU   B HD11 1 
ATOM   3328 H  HD12 . LEU   B 1 90  ? -21.441 12.271 36.667 1.00 26.53 ? 70  LEU   B HD12 1 
ATOM   3329 H  HD13 . LEU   B 1 90  ? -20.782 13.573 36.039 1.00 26.53 ? 70  LEU   B HD13 1 
ATOM   3330 H  HD21 . LEU   B 1 90  ? -17.998 13.018 36.964 1.00 21.29 ? 70  LEU   B HD21 1 
ATOM   3331 H  HD22 . LEU   B 1 90  ? -18.630 14.467 37.116 1.00 21.29 ? 70  LEU   B HD22 1 
ATOM   3332 H  HD23 . LEU   B 1 90  ? -18.060 13.711 38.391 1.00 21.29 ? 70  LEU   B HD23 1 
ATOM   3333 N  N    . GLY   B 1 91  ? -22.117 15.057 41.307 1.00 20.24 ? 71  GLY   B N    1 
ATOM   3334 C  CA   . GLY   B 1 91  ? -22.709 16.195 41.985 1.00 19.79 ? 71  GLY   B CA   1 
ATOM   3335 C  C    . GLY   B 1 91  ? -22.075 16.440 43.339 1.00 22.96 ? 71  GLY   B C    1 
ATOM   3336 O  O    . GLY   B 1 91  ? -21.877 17.588 43.746 1.00 21.75 ? 71  GLY   B O    1 
ATOM   3337 H  H    . GLY   B 1 91  ? -22.632 14.372 41.231 1.00 24.31 ? 71  GLY   B H    1 
ATOM   3338 H  HA2  . GLY   B 1 91  ? -22.596 16.991 41.442 1.00 23.76 ? 71  GLY   B HA2  1 
ATOM   3339 H  HA3  . GLY   B 1 91  ? -23.658 16.040 42.112 1.00 23.76 ? 71  GLY   B HA3  1 
ATOM   3340 N  N    . GLU   B 1 92  ? -21.729 15.364 44.046 1.00 22.83 ? 72  GLU   B N    1 
ATOM   3341 C  CA   . GLU   B 1 92  ? -20.997 15.507 45.298 1.00 26.82 ? 72  GLU   B CA   1 
ATOM   3342 C  C    . GLU   B 1 92  ? -19.620 16.110 45.055 1.00 24.26 ? 72  GLU   B C    1 
ATOM   3343 O  O    . GLU   B 1 92  ? -19.158 16.955 45.831 1.00 28.08 ? 72  GLU   B O    1 
ATOM   3344 C  CB   . GLU   B 1 92  ? -20.873 14.150 45.990 1.00 37.50 ? 72  GLU   B CB   1 
ATOM   3345 C  CG   . GLU   B 1 92  ? -22.189 13.606 46.511 1.00 45.61 ? 72  GLU   B CG   1 
ATOM   3346 C  CD   . GLU   B 1 92  ? -22.077 12.183 47.028 1.00 58.32 ? 72  GLU   B CD   1 
ATOM   3347 O  OE1  . GLU   B 1 92  ? -20.940 11.702 47.223 1.00 58.37 ? 72  GLU   B OE1  1 
ATOM   3348 O  OE2  . GLU   B 1 92  ? -23.132 11.544 47.230 1.00 56.79 ? 72  GLU   B OE2  1 
ATOM   3349 H  H    . GLU   B 1 92  ? -21.904 14.552 43.824 1.00 27.42 ? 72  GLU   B H    1 
ATOM   3350 H  HA   . GLU   B 1 92  ? -21.487 16.102 45.886 1.00 32.20 ? 72  GLU   B HA   1 
ATOM   3351 H  HB2  . GLU   B 1 92  ? -20.517 13.508 45.357 1.00 45.01 ? 72  GLU   B HB2  1 
ATOM   3352 H  HB3  . GLU   B 1 92  ? -20.269 14.238 46.744 1.00 45.01 ? 72  GLU   B HB3  1 
ATOM   3353 H  HG2  . GLU   B 1 92  ? -22.495 14.167 47.241 1.00 54.75 ? 72  GLU   B HG2  1 
ATOM   3354 H  HG3  . GLU   B 1 92  ? -22.840 13.613 45.792 1.00 54.75 ? 72  GLU   B HG3  1 
ATOM   3355 N  N    . HIS   B 1 93  ? -18.950 15.691 43.978 1.00 22.48 ? 73  HIS   B N    1 
ATOM   3356 C  CA   . HIS   B 1 93  ? -17.632 16.246 43.695 1.00 22.59 ? 73  HIS   B CA   1 
ATOM   3357 C  C    . HIS   B 1 93  ? -17.711 17.743 43.421 1.00 26.34 ? 73  HIS   B C    1 
ATOM   3358 O  O    . HIS   B 1 93  ? -16.750 18.473 43.690 1.00 20.15 ? 73  HIS   B O    1 
ATOM   3359 C  CB   . HIS   B 1 93  ? -16.973 15.549 42.504 1.00 22.18 ? 73  HIS   B CB   1 
ATOM   3360 C  CG   . HIS   B 1 93  ? -15.691 16.196 42.081 1.00 24.42 ? 73  HIS   B CG   1 
ATOM   3361 N  ND1  . HIS   B 1 93  ? -14.483 15.926 42.688 1.00 31.44 ? 73  HIS   B ND1  1 
ATOM   3362 C  CD2  . HIS   B 1 93  ? -15.437 17.139 41.143 1.00 25.94 ? 73  HIS   B CD2  1 
ATOM   3363 C  CE1  . HIS   B 1 93  ? -13.537 16.658 42.127 1.00 25.11 ? 73  HIS   B CE1  1 
ATOM   3364 N  NE2  . HIS   B 1 93  ? -14.091 17.406 41.189 1.00 28.66 ? 73  HIS   B NE2  1 
ATOM   3365 H  H    . HIS   B 1 93  ? -19.229 15.105 43.414 1.00 26.99 ? 73  HIS   B H    1 
ATOM   3366 H  HA   . HIS   B 1 93  ? -17.063 16.114 44.470 1.00 27.12 ? 73  HIS   B HA   1 
ATOM   3367 H  HB2  . HIS   B 1 93  ? -16.779 14.630 42.745 1.00 26.63 ? 73  HIS   B HB2  1 
ATOM   3368 H  HB3  . HIS   B 1 93  ? -17.582 15.571 41.750 1.00 26.63 ? 73  HIS   B HB3  1 
ATOM   3369 H  HD1  . HIS   B 1 93  ? -14.362 15.362 43.326 1.00 37.74 ? 73  HIS   B HD1  1 
ATOM   3370 H  HD2  . HIS   B 1 93  ? -16.058 17.529 40.570 1.00 31.14 ? 73  HIS   B HD2  1 
ATOM   3371 H  HE1  . HIS   B 1 93  ? -12.635 16.650 42.355 1.00 30.15 ? 73  HIS   B HE1  1 
ATOM   3372 N  N    . ALA   B 1 94  ? -18.832 18.218 42.871 1.00 22.35 ? 74  ALA   B N    1 
ATOM   3373 C  CA   . ALA   B 1 94  ? -18.960 19.646 42.598 1.00 22.01 ? 74  ALA   B CA   1 
ATOM   3374 C  C    . ALA   B 1 94  ? -18.832 20.466 43.874 1.00 22.26 ? 74  ALA   B C    1 
ATOM   3375 O  O    . ALA   B 1 94  ? -18.319 21.592 43.845 1.00 19.17 ? 74  ALA   B O    1 
ATOM   3376 C  CB   . ALA   B 1 94  ? -20.298 19.935 41.914 1.00 25.34 ? 74  ALA   B CB   1 
ATOM   3377 H  H    . ALA   B 1 94  ? -19.516 17.745 42.652 1.00 26.84 ? 74  ALA   B H    1 
ATOM   3378 H  HA   . ALA   B 1 94  ? -18.250 19.917 41.995 1.00 26.43 ? 74  ALA   B HA   1 
ATOM   3379 H  HB1  . ALA   B 1 94  ? -20.364 20.887 41.740 1.00 30.43 ? 74  ALA   B HB1  1 
ATOM   3380 H  HB2  . ALA   B 1 94  ? -20.338 19.442 41.079 1.00 30.43 ? 74  ALA   B HB2  1 
ATOM   3381 H  HB3  . ALA   B 1 94  ? -21.019 19.654 42.500 1.00 30.43 ? 74  ALA   B HB3  1 
ATOM   3382 N  N    . VAL   B 1 95  ? -19.292 19.919 45.000 1.00 23.60 ? 75  VAL   B N    1 
ATOM   3383 C  CA   . VAL   B 1 95  ? -19.152 20.610 46.278 1.00 23.15 ? 75  VAL   B CA   1 
ATOM   3384 C  C    . VAL   B 1 95  ? -17.681 20.828 46.599 1.00 19.73 ? 75  VAL   B C    1 
ATOM   3385 O  O    . VAL   B 1 95  ? -17.264 21.933 46.968 1.00 22.08 ? 75  VAL   B O    1 
ATOM   3386 C  CB   . VAL   B 1 95  ? -19.860 19.816 47.391 1.00 35.43 ? 75  VAL   B CB   1 
ATOM   3387 C  CG1  . VAL   B 1 95  ? -19.557 20.418 48.750 1.00 37.16 ? 75  VAL   B CG1  1 
ATOM   3388 C  CG2  . VAL   B 1 95  ? -21.354 19.781 47.129 1.00 31.39 ? 75  VAL   B CG2  1 
ATOM   3389 H  H    . VAL   B 1 95  ? -19.685 19.156 45.049 1.00 28.34 ? 75  VAL   B H    1 
ATOM   3390 H  HA   . VAL   B 1 95  ? -19.577 21.480 46.214 1.00 27.79 ? 75  VAL   B HA   1 
ATOM   3391 H  HB   . VAL   B 1 95  ? -19.532 18.903 47.387 1.00 42.54 ? 75  VAL   B HB   1 
ATOM   3392 H  HG11 . VAL   B 1 95  ? -20.114 19.979 49.409 1.00 44.61 ? 75  VAL   B HG11 1 
ATOM   3393 H  HG12 . VAL   B 1 95  ? -18.623 20.274 48.968 1.00 44.61 ? 75  VAL   B HG12 1 
ATOM   3394 H  HG13 . VAL   B 1 95  ? -19.753 21.368 48.728 1.00 44.61 ? 75  VAL   B HG13 1 
ATOM   3395 H  HG21 . VAL   B 1 95  ? -21.790 19.306 47.854 1.00 37.69 ? 75  VAL   B HG21 1 
ATOM   3396 H  HG22 . VAL   B 1 95  ? -21.687 20.691 47.081 1.00 37.69 ? 75  VAL   B HG22 1 
ATOM   3397 H  HG23 . VAL   B 1 95  ? -21.517 19.324 46.289 1.00 37.69 ? 75  VAL   B HG23 1 
ATOM   3398 N  N    . TRP   B 1 96  ? -16.875 19.769 46.474 1.00 21.66 ? 76  TRP   B N    1 
ATOM   3399 C  CA   . TRP   B 1 96  ? -15.442 19.901 46.711 1.00 24.02 ? 76  TRP   B CA   1 
ATOM   3400 C  C    . TRP   B 1 96  ? -14.800 20.815 45.680 1.00 34.21 ? 76  TRP   B C    1 
ATOM   3401 O  O    . TRP   B 1 96  ? -13.896 21.594 46.002 1.00 37.34 ? 76  TRP   B O    1 
ATOM   3402 C  CB   . TRP   B 1 96  ? -14.766 18.532 46.678 1.00 25.77 ? 76  TRP   B CB   1 
ATOM   3403 H  H    . TRP   B 1 96  ? -17.131 18.977 46.257 1.00 26.01 ? 76  TRP   B H    1 
ATOM   3404 H  HA   . TRP   B 1 96  ? -15.299 20.288 47.589 1.00 28.84 ? 76  TRP   B HA   1 
ATOM   3405 N  N    . SER   B 1 97  ? -15.230 20.706 44.421 1.00 22.03 ? 77  SER   B N    1 
ATOM   3406 C  CA   . SER   B 1 97  ? -14.678 21.559 43.375 1.00 22.72 ? 77  SER   B CA   1 
ATOM   3407 C  C    . SER   B 1 97  ? -14.824 23.030 43.738 1.00 23.04 ? 77  SER   B C    1 
ATOM   3408 O  O    . SER   B 1 97  ? -13.894 23.820 43.544 1.00 26.83 ? 77  SER   B O    1 
ATOM   3409 C  CB   . SER   B 1 97  ? -15.372 21.256 42.047 1.00 26.77 ? 77  SER   B CB   1 
ATOM   3410 O  OG   . SER   B 1 97  ? -14.734 21.904 40.966 1.00 29.79 ? 77  SER   B OG   1 
ATOM   3411 H  H    . SER   B 1 97  ? -15.832 20.153 44.152 1.00 26.45 ? 77  SER   B H    1 
ATOM   3412 H  HA   . SER   B 1 97  ? -13.733 21.366 43.273 1.00 27.28 ? 77  SER   B HA   1 
ATOM   3413 H  HB2  . SER   B 1 97  ? -15.351 20.298 41.894 1.00 32.14 ? 77  SER   B HB2  1 
ATOM   3414 H  HB3  . SER   B 1 97  ? -16.291 21.562 42.097 1.00 32.14 ? 77  SER   B HB3  1 
ATOM   3415 H  HG   . SER   B 1 97  ? -13.936 21.648 40.908 1.00 35.77 ? 77  SER   B HG   1 
ATOM   3416 N  N    . LEU   B 1 98  ? -15.979 23.416 44.280 1.00 24.70 ? 78  LEU   B N    1 
ATOM   3417 C  CA   . LEU   B 1 98  ? -16.216 24.814 44.605 1.00 27.96 ? 78  LEU   B CA   1 
ATOM   3418 C  C    . LEU   B 1 98  ? -15.470 25.262 45.848 1.00 32.80 ? 78  LEU   B C    1 
ATOM   3419 O  O    . LEU   B 1 98  ? -15.288 26.467 46.045 1.00 30.24 ? 78  LEU   B O    1 
ATOM   3420 C  CB   . LEU   B 1 98  ? -17.710 25.072 44.785 1.00 31.00 ? 78  LEU   B CB   1 
ATOM   3421 C  CG   . LEU   B 1 98  ? -18.450 25.319 43.473 0.64 27.20 ? 78  LEU   B CG   1 
ATOM   3422 C  CD1  . LEU   B 1 98  ? -19.918 25.010 43.666 1.00 29.32 ? 78  LEU   B CD1  1 
ATOM   3423 C  CD2  . LEU   B 1 98  ? -18.254 26.749 42.996 0.70 27.48 ? 78  LEU   B CD2  1 
ATOM   3424 H  H    . LEU   B 1 98  ? -16.634 22.890 44.466 1.00 29.66 ? 78  LEU   B H    1 
ATOM   3425 H  HA   . LEU   B 1 98  ? -15.909 25.360 43.865 1.00 33.57 ? 78  LEU   B HA   1 
ATOM   3426 H  HB2  . LEU   B 1 98  ? -18.112 24.300 45.213 1.00 37.22 ? 78  LEU   B HB2  1 
ATOM   3427 H  HB3  . LEU   B 1 98  ? -17.827 25.856 45.344 1.00 37.22 ? 78  LEU   B HB3  1 
ATOM   3428 H  HG   . LEU   B 1 98  ? -18.101 24.722 42.793 0.65 32.65 ? 78  LEU   B HG   1 
ATOM   3429 H  HD11 . LEU   B 1 98  ? -20.388 25.177 42.834 1.00 35.20 ? 78  LEU   B HD11 1 
ATOM   3430 H  HD12 . LEU   B 1 98  ? -20.011 24.078 43.918 1.00 35.20 ? 78  LEU   B HD12 1 
ATOM   3431 H  HD13 . LEU   B 1 98  ? -20.271 25.580 44.367 1.00 35.20 ? 78  LEU   B HD13 1 
ATOM   3432 H  HD21 . LEU   B 1 98  ? -18.737 26.873 42.164 0.69 32.99 ? 78  LEU   B HD21 1 
ATOM   3433 H  HD22 . LEU   B 1 98  ? -18.596 27.356 43.671 0.70 32.99 ? 78  LEU   B HD22 1 
ATOM   3434 H  HD23 . LEU   B 1 98  ? -17.308 26.908 42.856 0.71 32.99 ? 78  LEU   B HD23 1 
ATOM   3435 N  N    . GLN   B 1 99  ? -15.046 24.325 46.691 1.00 26.88 ? 79  GLN   B N    1 
ATOM   3436 C  CA   . GLN   B 1 99  ? -14.192 24.680 47.815 1.00 27.11 ? 79  GLN   B CA   1 
ATOM   3437 C  C    . GLN   B 1 99  ? -12.746 24.855 47.363 1.00 21.48 ? 79  GLN   B C    1 
ATOM   3438 O  O    . GLN   B 1 99  ? -12.093 25.843 47.713 1.00 25.43 ? 79  GLN   B O    1 
ATOM   3439 C  CB   . GLN   B 1 99  ? -14.295 23.611 48.904 1.00 25.40 ? 79  GLN   B CB   1 
ATOM   3440 H  H    . GLN   B 1 99  ? -15.236 23.488 46.635 1.00 32.27 ? 79  GLN   B H    1 
ATOM   3441 H  HA   . GLN   B 1 99  ? -14.494 25.522 48.191 1.00 32.54 ? 79  GLN   B HA   1 
ATOM   3442 N  N    . CYS   B 1 100 ? -12.242 23.919 46.565 1.00 19.85 ? 80  CYS   B N    1 
ATOM   3443 C  CA   . CYS   B 1 100 ? -10.826 23.893 46.226 1.00 17.81 ? 80  CYS   B CA   1 
ATOM   3444 C  C    . CYS   B 1 100 ? -10.484 24.706 44.987 1.00 17.41 ? 80  CYS   B C    1 
ATOM   3445 O  O    . CYS   B 1 100 ? -9.320  25.091 44.818 1.00 18.43 ? 80  CYS   B O    1 
ATOM   3446 C  CB   . CYS   B 1 100 ? -10.373 22.449 46.017 1.00 30.29 ? 80  CYS   B CB   1 
ATOM   3447 S  SG   . CYS   B 1 100 ? -10.554 21.426 47.479 1.00 54.03 ? 80  CYS   B SG   1 
ATOM   3448 H  H    . CYS   B 1 100 ? -12.701 23.286 46.206 1.00 23.83 ? 80  CYS   B H    1 
ATOM   3449 H  HA   . CYS   B 1 100 ? -10.320 24.258 46.969 1.00 21.39 ? 80  CYS   B HA   1 
ATOM   3450 H  HB2  . CYS   B 1 100 ? -10.904 22.053 45.309 1.00 36.36 ? 80  CYS   B HB2  1 
ATOM   3451 H  HB3  . CYS   B 1 100 ? -9.436  22.447 45.767 1.00 36.36 ? 80  CYS   B HB3  1 
ATOM   3452 H  HG   . CYS   B 1 100 ? -10.177 20.315 47.227 1.00 64.85 ? 80  CYS   B HG   1 
ATOM   3453 N  N    . PHE   B 1 101 ? -11.456 24.955 44.119 1.00 18.44 ? 81  PHE   B N    1 
ATOM   3454 C  CA   . PHE   B 1 101 ? -11.281 25.788 42.930 1.00 18.34 ? 81  PHE   B CA   1 
ATOM   3455 C  C    . PHE   B 1 101 ? -12.422 26.799 42.904 1.00 17.29 ? 81  PHE   B C    1 
ATOM   3456 O  O    . PHE   B 1 101 ? -13.309 26.738 42.042 1.00 16.03 ? 81  PHE   B O    1 
ATOM   3457 C  CB   . PHE   B 1 101 ? -11.286 24.956 41.650 1.00 14.89 ? 81  PHE   B CB   1 
ATOM   3458 C  CG   . PHE   B 1 101 ? -10.187 23.941 41.556 1.00 15.02 ? 81  PHE   B CG   1 
ATOM   3459 C  CD1  . PHE   B 1 101 ? -8.873  24.329 41.368 1.00 16.10 ? 81  PHE   B CD1  1 
ATOM   3460 C  CD2  . PHE   B 1 101 ? -10.480 22.587 41.595 1.00 17.56 ? 81  PHE   B CD2  1 
ATOM   3461 C  CE1  . PHE   B 1 101 ? -7.870  23.380 41.244 1.00 19.49 ? 81  PHE   B CE1  1 
ATOM   3462 C  CE2  . PHE   B 1 101 ? -9.481  21.639 41.483 1.00 19.20 ? 81  PHE   B CE2  1 
ATOM   3463 C  CZ   . PHE   B 1 101 ? -8.177  22.037 41.298 1.00 16.36 ? 81  PHE   B CZ   1 
ATOM   3464 H  H    . PHE   B 1 101 ? -12.253 24.643 44.198 1.00 22.14 ? 81  PHE   B H    1 
ATOM   3465 H  HA   . PHE   B 1 101 ? -10.440 26.267 42.984 1.00 22.03 ? 81  PHE   B HA   1 
ATOM   3466 H  HB2  . PHE   B 1 101 ? -12.130 24.482 41.592 1.00 17.89 ? 81  PHE   B HB2  1 
ATOM   3467 H  HB3  . PHE   B 1 101 ? -11.196 25.555 40.893 1.00 17.89 ? 81  PHE   B HB3  1 
ATOM   3468 H  HD1  . PHE   B 1 101 ? -8.661  25.233 41.324 1.00 19.34 ? 81  PHE   B HD1  1 
ATOM   3469 H  HD2  . PHE   B 1 101 ? -11.361 22.312 41.713 1.00 21.09 ? 81  PHE   B HD2  1 
ATOM   3470 H  HE1  . PHE   B 1 101 ? -6.988  23.650 41.128 1.00 23.41 ? 81  PHE   B HE1  1 
ATOM   3471 H  HE2  . PHE   B 1 101 ? -9.691  20.734 41.519 1.00 23.06 ? 81  PHE   B HE2  1 
ATOM   3472 H  HZ   . PHE   B 1 101 ? -7.502  21.402 41.226 1.00 19.65 ? 81  PHE   B HZ   1 
ATOM   3473 N  N    . PRO   B 1 102 ? -12.433 27.743 43.847 1.00 16.87 ? 82  PRO   B N    1 
ATOM   3474 C  CA   . PRO   B 1 102 ? -13.669 28.504 44.102 1.00 17.72 ? 82  PRO   B CA   1 
ATOM   3475 C  C    . PRO   B 1 102 ? -14.076 29.441 42.984 1.00 19.30 ? 82  PRO   B C    1 
ATOM   3476 O  O    . PRO   B 1 102 ? -15.262 29.785 42.906 1.00 22.89 ? 82  PRO   B O    1 
ATOM   3477 C  CB   . PRO   B 1 102 ? -13.350 29.284 45.386 1.00 20.16 ? 82  PRO   B CB   1 
ATOM   3478 C  CG   . PRO   B 1 102 ? -11.848 29.352 45.421 1.00 23.18 ? 82  PRO   B CG   1 
ATOM   3479 C  CD   . PRO   B 1 102 ? -11.369 28.065 44.817 1.00 16.11 ? 82  PRO   B CD   1 
ATOM   3480 H  HA   . PRO   B 1 102 ? -14.401 27.893 44.279 1.00 21.28 ? 82  PRO   B HA   1 
ATOM   3481 H  HB2  . PRO   B 1 102 ? -13.734 30.173 45.335 1.00 24.21 ? 82  PRO   B HB2  1 
ATOM   3482 H  HB3  . PRO   B 1 102 ? -13.692 28.803 46.156 1.00 24.21 ? 82  PRO   B HB3  1 
ATOM   3483 H  HG2  . PRO   B 1 102 ? -11.544 30.109 44.896 1.00 27.83 ? 82  PRO   B HG2  1 
ATOM   3484 H  HG3  . PRO   B 1 102 ? -11.547 29.431 46.340 1.00 27.83 ? 82  PRO   B HG3  1 
ATOM   3485 H  HD2  . PRO   B 1 102 ? -10.523 28.198 44.362 1.00 19.35 ? 82  PRO   B HD2  1 
ATOM   3486 H  HD3  . PRO   B 1 102 ? -11.307 27.374 45.495 1.00 19.35 ? 82  PRO   B HD3  1 
ATOM   3487 N  N    . ASP   B 1 103 ? -13.156 29.866 42.118 1.00 18.15 ? 83  ASP   B N    1 
ATOM   3488 C  CA   . ASP   B 1 103 ? -13.501 30.834 41.083 1.00 16.50 ? 83  ASP   B CA   1 
ATOM   3489 C  C    . ASP   B 1 103 ? -13.034 30.381 39.703 1.00 15.84 ? 83  ASP   B C    1 
ATOM   3490 O  O    . ASP   B 1 103 ? -12.736 31.208 38.840 1.00 19.08 ? 83  ASP   B O    1 
ATOM   3491 C  CB   . ASP   B 1 103 ? -12.938 32.216 41.422 1.00 17.53 ? 83  ASP   B CB   1 
ATOM   3492 C  CG   . ASP   B 1 103 ? -11.418 32.251 41.444 1.00 27.15 ? 83  ASP   B CG   1 
ATOM   3493 O  OD1  . ASP   B 1 103 ? -10.783 31.182 41.340 1.00 21.97 ? 83  ASP   B OD1  1 
ATOM   3494 O  OD2  . ASP   B 1 103 ? -10.861 33.360 41.560 1.00 27.47 ? 83  ASP   B OD2  1 
ATOM   3495 H  H    . ASP   B 1 103 ? -12.335 29.611 42.109 1.00 21.80 ? 83  ASP   B H    1 
ATOM   3496 H  HA   . ASP   B 1 103 ? -14.466 30.919 41.043 1.00 19.82 ? 83  ASP   B HA   1 
ATOM   3497 H  HB2  . ASP   B 1 103 ? -13.242 32.854 40.759 1.00 21.06 ? 83  ASP   B HB2  1 
ATOM   3498 H  HB3  . ASP   B 1 103 ? -13.255 32.477 42.301 1.00 21.06 ? 83  ASP   B HB3  1 
ATOM   3499 N  N    . TRP   B 1 104 ? -13.028 29.072 39.468 1.00 14.65 ? 84  TRP   B N    1 
ATOM   3500 C  CA   . TRP   B 1 104 ? -12.438 28.513 38.261 1.00 16.29 ? 84  TRP   B CA   1 
ATOM   3501 C  C    . TRP   B 1 104 ? -13.151 28.990 37.002 1.00 15.81 ? 84  TRP   B C    1 
ATOM   3502 O  O    . TRP   B 1 104 ? -14.382 28.987 36.936 1.00 16.74 ? 84  TRP   B O    1 
ATOM   3503 C  CB   . TRP   B 1 104 ? -12.473 26.982 38.338 1.00 14.94 ? 84  TRP   B CB   1 
ATOM   3504 C  CG   . TRP   B 1 104 ? -11.661 26.343 37.278 1.00 14.40 ? 84  TRP   B CG   1 
ATOM   3505 C  CD1  . TRP   B 1 104 ? -12.104 25.755 36.128 1.00 13.81 ? 84  TRP   B CD1  1 
ATOM   3506 C  CD2  . TRP   B 1 104 ? -10.239 26.256 37.252 1.00 14.49 ? 84  TRP   B CD2  1 
ATOM   3507 N  NE1  . TRP   B 1 104 ? -11.036 25.296 35.391 1.00 14.37 ? 84  TRP   B NE1  1 
ATOM   3508 C  CE2  . TRP   B 1 104 ? -9.879  25.593 36.065 1.00 11.89 ? 84  TRP   B CE2  1 
ATOM   3509 C  CE3  . TRP   B 1 104 ? -9.233  26.666 38.129 1.00 14.09 ? 84  TRP   B CE3  1 
ATOM   3510 C  CZ2  . TRP   B 1 104 ? -8.552  25.329 35.735 1.00 14.62 ? 84  TRP   B CZ2  1 
ATOM   3511 C  CZ3  . TRP   B 1 104 ? -7.926  26.420 37.794 1.00 13.30 ? 84  TRP   B CZ3  1 
ATOM   3512 C  CH2  . TRP   B 1 104 ? -7.594  25.752 36.612 1.00 13.67 ? 84  TRP   B CH2  1 
ATOM   3513 H  H    . TRP   B 1 104 ? -13.363 28.483 39.998 1.00 17.59 ? 84  TRP   B H    1 
ATOM   3514 H  HA   . TRP   B 1 104 ? -11.510 28.790 38.204 1.00 19.57 ? 84  TRP   B HA   1 
ATOM   3515 H  HB2  . TRP   B 1 104 ? -12.122 26.701 39.197 1.00 17.94 ? 84  TRP   B HB2  1 
ATOM   3516 H  HB3  . TRP   B 1 104 ? -13.389 26.681 38.238 1.00 17.94 ? 84  TRP   B HB3  1 
ATOM   3517 H  HD1  . TRP   B 1 104 ? -12.997 25.675 35.880 1.00 16.59 ? 84  TRP   B HD1  1 
ATOM   3518 H  HE1  . TRP   B 1 104 ? -11.086 24.889 34.636 1.00 17.26 ? 84  TRP   B HE1  1 
ATOM   3519 H  HE3  . TRP   B 1 104 ? -9.444  27.110 38.918 1.00 16.93 ? 84  TRP   B HE3  1 
ATOM   3520 H  HZ2  . TRP   B 1 104 ? -8.327  24.892 34.945 1.00 17.56 ? 84  TRP   B HZ2  1 
ATOM   3521 H  HZ3  . TRP   B 1 104 ? -7.249  26.687 38.373 1.00 15.97 ? 84  TRP   B HZ3  1 
ATOM   3522 H  HH2  . TRP   B 1 104 ? -6.699  25.594 36.416 1.00 16.42 ? 84  TRP   B HH2  1 
ATOM   3523 N  N    . VAL   B 1 105 ? -12.367 29.377 35.996 1.00 14.16 ? 85  VAL   B N    1 
ATOM   3524 C  CA   . VAL   B 1 105 ? -12.880 29.740 34.682 1.00 13.74 ? 85  VAL   B CA   1 
ATOM   3525 C  C    . VAL   B 1 105 ? -12.113 28.974 33.615 1.00 14.90 ? 85  VAL   B C    1 
ATOM   3526 O  O    . VAL   B 1 105 ? -10.881 28.884 33.664 1.00 14.16 ? 85  VAL   B O    1 
ATOM   3527 C  CB   . VAL   B 1 105 ? -12.751 31.261 34.428 1.00 17.32 ? 85  VAL   B CB   1 
ATOM   3528 C  CG1  . VAL   B 1 105 ? -13.229 31.620 33.029 1.00 21.22 ? 85  VAL   B CG1  1 
ATOM   3529 C  CG2  . VAL   B 1 105 ? -13.499 32.043 35.493 1.00 20.81 ? 85  VAL   B CG2  1 
ATOM   3530 H  H    . VAL   B 1 105 ? -11.511 29.438 36.056 1.00 17.01 ? 85  VAL   B H    1 
ATOM   3531 H  HA   . VAL   B 1 105 ? -13.817 29.497 34.620 1.00 16.51 ? 85  VAL   B HA   1 
ATOM   3532 H  HB   . VAL   B 1 105 ? -11.814 31.506 34.489 1.00 20.80 ? 85  VAL   B HB   1 
ATOM   3533 H  HG11 . VAL   B 1 105 ? -13.382 32.577 32.984 1.00 25.48 ? 85  VAL   B HG11 1 
ATOM   3534 H  HG12 . VAL   B 1 105 ? -12.549 31.365 32.386 1.00 25.48 ? 85  VAL   B HG12 1 
ATOM   3535 H  HG13 . VAL   B 1 105 ? -14.055 31.145 32.846 1.00 25.48 ? 85  VAL   B HG13 1 
ATOM   3536 H  HG21 . VAL   B 1 105 ? -13.500 32.983 35.254 1.00 24.99 ? 85  VAL   B HG21 1 
ATOM   3537 H  HG22 . VAL   B 1 105 ? -14.409 31.713 35.544 1.00 24.99 ? 85  VAL   B HG22 1 
ATOM   3538 H  HG23 . VAL   B 1 105 ? -13.054 31.918 36.346 1.00 24.99 ? 85  VAL   B HG23 1 
ATOM   3539 N  N    . TRP   B 1 106 ? -12.843 28.427 32.643 1.00 16.77 ? 86  TRP   B N    1 
ATOM   3540 C  CA   . TRP   B 1 106 ? -12.243 27.957 31.402 1.00 14.59 ? 86  TRP   B CA   1 
ATOM   3541 C  C    . TRP   B 1 106 ? -12.214 29.088 30.380 1.00 13.38 ? 86  TRP   B C    1 
ATOM   3542 O  O    . TRP   B 1 106 ? -13.248 29.708 30.109 1.00 17.48 ? 86  TRP   B O    1 
ATOM   3543 C  CB   . TRP   B 1 106 ? -13.024 26.790 30.812 1.00 13.61 ? 86  TRP   B CB   1 
ATOM   3544 C  CG   . TRP   B 1 106 ? -13.246 25.662 31.722 1.00 10.94 ? 86  TRP   B CG   1 
ATOM   3545 C  CD1  . TRP   B 1 106 ? -14.432 25.301 32.287 1.00 12.38 ? 86  TRP   B CD1  1 
ATOM   3546 C  CD2  . TRP   B 1 106 ? -12.273 24.707 32.172 1.00 12.32 ? 86  TRP   B CD2  1 
ATOM   3547 N  NE1  . TRP   B 1 106 ? -14.259 24.184 33.068 1.00 14.08 ? 86  TRP   B NE1  1 
ATOM   3548 C  CE2  . TRP   B 1 106 ? -12.945 23.796 33.010 1.00 15.34 ? 86  TRP   B CE2  1 
ATOM   3549 C  CE3  . TRP   B 1 106 ? -10.900 24.535 31.952 1.00 13.99 ? 86  TRP   B CE3  1 
ATOM   3550 C  CZ2  . TRP   B 1 106 ? -12.293 22.731 33.635 1.00 16.18 ? 86  TRP   B CZ2  1 
ATOM   3551 C  CZ3  . TRP   B 1 106 ? -10.253 23.471 32.572 1.00 14.13 ? 86  TRP   B CZ3  1 
ATOM   3552 C  CH2  . TRP   B 1 106 ? -10.951 22.584 33.405 1.00 13.87 ? 86  TRP   B CH2  1 
ATOM   3553 H  H    . TRP   B 1 106 ? -13.695 28.317 32.682 1.00 20.14 ? 86  TRP   B H    1 
ATOM   3554 H  HA   . TRP   B 1 106 ? -11.333 27.667 31.569 1.00 17.53 ? 86  TRP   B HA   1 
ATOM   3555 H  HB2  . TRP   B 1 106 ? -13.894 27.113 30.531 1.00 16.35 ? 86  TRP   B HB2  1 
ATOM   3556 H  HB3  . TRP   B 1 106 ? -12.539 26.453 30.043 1.00 16.35 ? 86  TRP   B HB3  1 
ATOM   3557 H  HD1  . TRP   B 1 106 ? -15.240 25.744 32.160 1.00 14.88 ? 86  TRP   B HD1  1 
ATOM   3558 H  HE1  . TRP   B 1 106 ? -14.877 23.788 33.516 1.00 16.92 ? 86  TRP   B HE1  1 
ATOM   3559 H  HE3  . TRP   B 1 106 ? -10.432 25.118 31.399 1.00 16.81 ? 86  TRP   B HE3  1 
ATOM   3560 H  HZ2  . TRP   B 1 106 ? -12.753 22.144 34.190 1.00 19.43 ? 86  TRP   B HZ2  1 
ATOM   3561 H  HZ3  . TRP   B 1 106 ? -9.343  23.345 32.432 1.00 16.97 ? 86  TRP   B HZ3  1 
ATOM   3562 H  HH2  . TRP   B 1 106 ? -10.494 21.882 33.808 1.00 16.66 ? 86  TRP   B HH2  1 
ATOM   3563 N  N    . THR   B 1 107 ? -11.045 29.333 29.794 1.00 14.12 ? 87  THR   B N    1 
ATOM   3564 C  CA   . THR   B 1 107 ? -10.864 30.390 28.811 1.00 15.99 ? 87  THR   B CA   1 
ATOM   3565 C  C    . THR   B 1 107 ? -10.325 29.807 27.508 1.00 17.39 ? 87  THR   B C    1 
ATOM   3566 O  O    . THR   B 1 107 ? -9.900  28.650 27.445 1.00 14.59 ? 87  THR   B O    1 
ATOM   3567 C  CB   . THR   B 1 107 ? -9.899  31.470 29.322 1.00 18.28 ? 87  THR   B CB   1 
ATOM   3568 O  OG1  . THR   B 1 107 ? -8.592  30.903 29.473 1.00 19.19 ? 87  THR   B OG1  1 
ATOM   3569 C  CG2  . THR   B 1 107 ? -10.345 32.030 30.660 1.00 21.42 ? 87  THR   B CG2  1 
ATOM   3570 H  H    . THR   B 1 107 ? -10.327 28.888 29.955 1.00 16.96 ? 87  THR   B H    1 
ATOM   3571 H  HA   . THR   B 1 107 ? -11.718 30.810 28.625 1.00 19.20 ? 87  THR   B HA   1 
ATOM   3572 H  HB   . THR   B 1 107 ? -9.862  32.198 28.682 1.00 21.96 ? 87  THR   B HB   1 
ATOM   3573 H  HG1  . THR   B 1 107 ? -8.269  30.717 28.720 1.00 23.04 ? 87  THR   B HG1  1 
ATOM   3574 H  HG21 . THR   B 1 107 ? -9.751  32.747 30.934 1.00 25.72 ? 87  THR   B HG21 1 
ATOM   3575 H  HG22 . THR   B 1 107 ? -11.247 32.379 30.589 1.00 25.72 ? 87  THR   B HG22 1 
ATOM   3576 H  HG23 . THR   B 1 107 ? -10.329 31.333 31.334 1.00 25.72 ? 87  THR   B HG23 1 
ATOM   3577 N  N    . ASP   B 1 108 ? -10.316 30.633 26.461 1.00 17.27 ? 88  ASP   B N    1 
ATOM   3578 C  CA   . ASP   B 1 108 ? -9.678  30.258 25.196 1.00 18.09 ? 88  ASP   B CA   1 
ATOM   3579 C  C    . ASP   B 1 108 ? -10.238 28.946 24.665 1.00 16.24 ? 88  ASP   B C    1 
ATOM   3580 O  O    . ASP   B 1 108 ? -9.501  28.070 24.211 1.00 17.21 ? 88  ASP   B O    1 
ATOM   3581 C  CB   . ASP   B 1 108 ? -8.164  30.165 25.367 1.00 19.63 ? 88  ASP   B CB   1 
ATOM   3582 C  CG   . ASP   B 1 108 ? -7.566  31.464 25.820 1.00 29.21 ? 88  ASP   B CG   1 
ATOM   3583 O  OD1  . ASP   B 1 108 ? -7.485  32.388 24.991 1.00 27.07 ? 88  ASP   B OD1  1 
ATOM   3584 O  OD2  . ASP   B 1 108 ? -7.214  31.573 27.014 1.00 24.12 ? 88  ASP   B OD2  1 
ATOM   3585 H  H    . ASP   B 1 108 ? -10.672 31.416 26.456 1.00 20.74 ? 88  ASP   B H    1 
ATOM   3586 H  HA   . ASP   B 1 108 ? -9.861  30.947 24.538 1.00 21.72 ? 88  ASP   B HA   1 
ATOM   3587 H  HB2  . ASP   B 1 108 ? -7.959  29.490 26.032 1.00 23.57 ? 88  ASP   B HB2  1 
ATOM   3588 H  HB3  . ASP   B 1 108 ? -7.762  29.928 24.517 1.00 23.57 ? 88  ASP   B HB3  1 
ATOM   3589 N  N    . ILE   B 1 109 ? -11.555 28.816 24.715 1.00 14.93 ? 89  ILE   B N    1 
ATOM   3590 C  CA   . ILE   B 1 109 ? -12.218 27.556 24.417 1.00 15.98 ? 89  ILE   B CA   1 
ATOM   3591 C  C    . ILE   B 1 109 ? -12.290 27.361 22.911 1.00 20.62 ? 89  ILE   B C    1 
ATOM   3592 O  O    . ILE   B 1 109 ? -12.840 28.197 22.187 1.00 18.14 ? 89  ILE   B O    1 
ATOM   3593 C  CB   . ILE   B 1 109 ? -13.620 27.531 25.038 1.00 15.86 ? 89  ILE   B CB   1 
ATOM   3594 C  CG1  . ILE   B 1 109 ? -13.540 27.645 26.560 1.00 16.86 ? 89  ILE   B CG1  1 
ATOM   3595 C  CG2  . ILE   B 1 109 ? -14.361 26.267 24.639 1.00 19.43 ? 89  ILE   B CG2  1 
ATOM   3596 C  CD1  . ILE   B 1 109 ? -14.859 28.047 27.180 1.00 16.88 ? 89  ILE   B CD1  1 
ATOM   3597 H  H    . ILE   B 1 109 ? -12.095 29.452 24.922 1.00 17.94 ? 89  ILE   B H    1 
ATOM   3598 H  HA   . ILE   B 1 109 ? -11.704 26.825 24.795 1.00 19.19 ? 89  ILE   B HA   1 
ATOM   3599 H  HB   . ILE   B 1 109 ? -14.116 28.294 24.701 1.00 19.05 ? 89  ILE   B HB   1 
ATOM   3600 H  HG12 . ILE   B 1 109 ? -13.285 26.785 26.928 1.00 20.25 ? 89  ILE   B HG12 1 
ATOM   3601 H  HG13 . ILE   B 1 109 ? -12.882 28.316 26.798 1.00 20.25 ? 89  ILE   B HG13 1 
ATOM   3602 H  HG21 . ILE   B 1 109 ? -15.144 26.164 25.201 1.00 23.34 ? 89  ILE   B HG21 1 
ATOM   3603 H  HG22 . ILE   B 1 109 ? -14.633 26.337 23.711 1.00 23.34 ? 89  ILE   B HG22 1 
ATOM   3604 H  HG23 . ILE   B 1 109 ? -13.771 25.506 24.756 1.00 23.34 ? 89  ILE   B HG23 1 
ATOM   3605 H  HD11 . ILE   B 1 109 ? -14.736 28.159 28.136 1.00 20.28 ? 89  ILE   B HD11 1 
ATOM   3606 H  HD12 . ILE   B 1 109 ? -15.150 28.884 26.785 1.00 20.28 ? 89  ILE   B HD12 1 
ATOM   3607 H  HD13 . ILE   B 1 109 ? -15.517 27.355 27.011 1.00 20.28 ? 89  ILE   B HD13 1 
ATOM   3608 N  N    . GLN   B 1 110 ? -11.754 26.241 22.440 0.95 14.55 ? 90  GLN   B N    1 
ATOM   3609 C  CA   . GLN   B 1 110 ? -11.905 25.803 21.059 0.95 14.73 ? 90  GLN   B CA   1 
ATOM   3610 C  C    . GLN   B 1 110 ? -12.538 24.420 21.075 0.95 19.56 ? 90  GLN   B C    1 
ATOM   3611 O  O    . GLN   B 1 110 ? -11.933 23.469 21.575 0.95 14.19 ? 90  GLN   B O    1 
ATOM   3612 C  CB   . GLN   B 1 110 ? -10.564 25.747 20.338 0.95 14.30 ? 90  GLN   B CB   1 
ATOM   3613 C  CG   . GLN   B 1 110 ? -9.830  27.050 20.246 0.95 27.31 ? 90  GLN   B CG   1 
ATOM   3614 C  CD   . GLN   B 1 110 ? -8.515  26.887 19.511 0.95 42.21 ? 90  GLN   B CD   1 
ATOM   3615 O  OE1  . GLN   B 1 110 ? -8.427  27.136 18.308 0.95 32.51 ? 90  GLN   B OE1  1 
ATOM   3616 N  NE2  . GLN   B 1 110 ? -7.485  26.434 20.230 0.95 24.97 ? 90  GLN   B NE2  1 
ATOM   3617 H  H    . GLN   B 1 110 ? -11.284 25.702 22.917 0.95 17.48 ? 90  GLN   B H    1 
ATOM   3618 H  HA   . GLN   B 1 110 ? -12.492 26.409 20.581 0.95 17.69 ? 90  GLN   B HA   1 
ATOM   3619 H  HB2  . GLN   B 1 110 ? -9.989  25.124 20.810 0.95 17.18 ? 90  GLN   B HB2  1 
ATOM   3620 H  HB3  . GLN   B 1 110 ? -10.712 25.429 19.434 0.95 17.18 ? 90  GLN   B HB3  1 
ATOM   3621 H  HG2  . GLN   B 1 110 ? -10.373 27.691 19.761 0.95 32.79 ? 90  GLN   B HG2  1 
ATOM   3622 H  HG3  . GLN   B 1 110 ? -9.641  27.376 21.140 0.95 32.79 ? 90  GLN   B HG3  1 
ATOM   3623 H  HE21 . GLN   B 1 110 ? -7.586  26.266 21.067 0.95 29.99 ? 90  GLN   B HE21 1 
ATOM   3624 H  HE22 . GLN   B 1 110 ? -6.718  26.322 19.858 0.95 29.99 ? 90  GLN   B HE22 1 
ATOM   3625 N  N    . ILE   B 1 111 ? -13.741 24.305 20.526 1.00 14.87 ? 91  ILE   B N    1 
ATOM   3626 C  CA   . ILE   B 1 111 ? -14.466 23.039 20.484 1.00 13.79 ? 91  ILE   B CA   1 
ATOM   3627 C  C    . ILE   B 1 111 ? -14.219 22.365 19.144 1.00 18.25 ? 91  ILE   B C    1 
ATOM   3628 O  O    . ILE   B 1 111 ? -14.351 22.993 18.083 1.00 18.02 ? 91  ILE   B O    1 
ATOM   3629 C  CB   . ILE   B 1 111 ? -15.973 23.246 20.717 1.00 15.26 ? 91  ILE   B CB   1 
ATOM   3630 C  CG1  . ILE   B 1 111 ? -16.202 23.805 22.120 1.00 18.84 ? 91  ILE   B CG1  1 
ATOM   3631 C  CG2  . ILE   B 1 111 ? -16.717 21.933 20.527 1.00 18.37 ? 91  ILE   B CG2  1 
ATOM   3632 C  CD1  . ILE   B 1 111 ? -17.634 24.194 22.419 1.00 26.53 ? 91  ILE   B CD1  1 
ATOM   3633 H  H    . ILE   B 1 111 ? -14.167 24.958 20.164 1.00 17.87 ? 91  ILE   B H    1 
ATOM   3634 H  HA   . ILE   B 1 111 ? -14.131 22.455 21.182 1.00 16.57 ? 91  ILE   B HA   1 
ATOM   3635 H  HB   . ILE   B 1 111 ? -16.303 23.887 20.069 1.00 18.33 ? 91  ILE   B HB   1 
ATOM   3636 H  HG12 . ILE   B 1 111 ? -15.939 23.133 22.768 1.00 22.62 ? 91  ILE   B HG12 1 
ATOM   3637 H  HG13 . ILE   B 1 111 ? -15.655 24.598 22.233 1.00 22.62 ? 91  ILE   B HG13 1 
ATOM   3638 H  HG21 . ILE   B 1 111 ? -17.621 22.024 20.866 1.00 22.07 ? 91  ILE   B HG21 1 
ATOM   3639 H  HG22 . ILE   B 1 111 ? -16.746 21.716 19.582 1.00 22.07 ? 91  ILE   B HG22 1 
ATOM   3640 H  HG23 . ILE   B 1 111 ? -16.252 21.235 21.014 1.00 22.07 ? 91  ILE   B HG23 1 
ATOM   3641 H  HD11 . ILE   B 1 111 ? -17.653 24.730 23.227 1.00 31.85 ? 91  ILE   B HD11 1 
ATOM   3642 H  HD12 . ILE   B 1 111 ? -17.982 24.707 21.673 1.00 31.85 ? 91  ILE   B HD12 1 
ATOM   3643 H  HD13 . ILE   B 1 111 ? -18.163 23.391 22.542 1.00 31.85 ? 91  ILE   B HD13 1 
ATOM   3644 N  N    . PHE   B 1 112 ? -13.884 21.077 19.188 1.00 13.77 ? 92  PHE   B N    1 
ATOM   3645 C  CA   . PHE   B 1 112 ? -13.660 20.286 17.985 1.00 14.80 ? 92  PHE   B CA   1 
ATOM   3646 C  C    . PHE   B 1 112 ? -14.718 19.193 17.868 1.00 15.61 ? 92  PHE   B C    1 
ATOM   3647 O  O    . PHE   B 1 112 ? -14.753 18.261 18.677 1.00 15.19 ? 92  PHE   B O    1 
ATOM   3648 C  CB   . PHE   B 1 112 ? -12.257 19.685 18.005 1.00 14.75 ? 92  PHE   B CB   1 
ATOM   3649 C  CG   . PHE   B 1 112 ? -11.158 20.706 18.018 1.00 14.85 ? 92  PHE   B CG   1 
ATOM   3650 C  CD1  . PHE   B 1 112 ? -10.723 21.276 16.836 1.00 17.52 ? 92  PHE   B CD1  1 
ATOM   3651 C  CD2  . PHE   B 1 112 ? -10.563 21.096 19.205 1.00 13.09 ? 92  PHE   B CD2  1 
ATOM   3652 C  CE1  . PHE   B 1 112 ? -9.709  22.217 16.830 1.00 17.93 ? 92  PHE   B CE1  1 
ATOM   3653 C  CE2  . PHE   B 1 112 ? -9.545  22.042 19.207 1.00 14.21 ? 92  PHE   B CE2  1 
ATOM   3654 C  CZ   . PHE   B 1 112 ? -9.118  22.601 18.016 1.00 20.33 ? 92  PHE   B CZ   1 
ATOM   3655 H  H    . PHE   B 1 112 ? -13.779 20.633 19.917 1.00 16.54 ? 92  PHE   B H    1 
ATOM   3656 H  HA   . PHE   B 1 112 ? -13.731 20.858 17.205 1.00 17.78 ? 92  PHE   B HA   1 
ATOM   3657 H  HB2  . PHE   B 1 112 ? -12.163 19.139 18.801 1.00 17.71 ? 92  PHE   B HB2  1 
ATOM   3658 H  HB3  . PHE   B 1 112 ? -12.141 19.136 17.214 1.00 17.71 ? 92  PHE   B HB3  1 
ATOM   3659 H  HD1  . PHE   B 1 112 ? -11.115 21.020 16.033 1.00 21.04 ? 92  PHE   B HD1  1 
ATOM   3660 H  HD2  . PHE   B 1 112 ? -10.846 20.721 20.008 1.00 15.72 ? 92  PHE   B HD2  1 
ATOM   3661 H  HE1  . PHE   B 1 112 ? -9.426  22.591 16.027 1.00 21.53 ? 92  PHE   B HE1  1 
ATOM   3662 H  HE2  . PHE   B 1 112 ? -9.150  22.298 20.009 1.00 17.07 ? 92  PHE   B HE2  1 
ATOM   3663 H  HZ   . PHE   B 1 112 ? -8.438  23.235 18.015 1.00 24.41 ? 92  PHE   B HZ   1 
ATOM   3664 N  N    . GLU   B 1 113 ? -15.589 19.325 16.869 1.00 15.03 ? 93  GLU   B N    1 
ATOM   3665 C  CA   . GLU   B 1 113 ? -16.411 18.209 16.433 1.00 15.78 ? 93  GLU   B CA   1 
ATOM   3666 C  C    . GLU   B 1 113 ? -15.507 17.146 15.828 1.00 15.63 ? 93  GLU   B C    1 
ATOM   3667 O  O    . GLU   B 1 113 ? -14.363 17.421 15.461 1.00 17.71 ? 93  GLU   B O    1 
ATOM   3668 C  CB   . GLU   B 1 113 ? -17.448 18.674 15.416 1.00 22.85 ? 93  GLU   B CB   1 
ATOM   3669 C  CG   . GLU   B 1 113 ? -18.250 19.871 15.891 1.00 27.12 ? 93  GLU   B CG   1 
ATOM   3670 C  CD   . GLU   B 1 113 ? -19.039 20.527 14.774 1.00 37.81 ? 93  GLU   B CD   1 
ATOM   3671 O  OE1  . GLU   B 1 113 ? -18.985 20.028 13.630 1.00 29.01 ? 93  GLU   B OE1  1 
ATOM   3672 O  OE2  . GLU   B 1 113 ? -19.707 21.545 15.046 1.00 44.65 ? 93  GLU   B OE2  1 
ATOM   3673 H  H    . GLU   B 1 113 ? -15.713 20.051 16.426 1.00 18.05 ? 93  GLU   B H    1 
ATOM   3674 H  HA   . GLU   B 1 113 ? -16.873 17.827 17.195 1.00 18.96 ? 93  GLU   B HA   1 
ATOM   3675 H  HB2  . GLU   B 1 113 ? -16.994 18.923 14.596 1.00 27.44 ? 93  GLU   B HB2  1 
ATOM   3676 H  HB3  . GLU   B 1 113 ? -18.065 17.947 15.245 1.00 27.44 ? 93  GLU   B HB3  1 
ATOM   3677 H  HG2  . GLU   B 1 113 ? -18.882 19.578 16.564 1.00 32.56 ? 93  GLU   B HG2  1 
ATOM   3678 H  HG3  . GLU   B 1 113 ? -17.657 20.540 16.263 1.00 32.56 ? 93  GLU   B HG3  1 
ATOM   3679 N  N    . THR   B 1 114 ? -16.006 15.914 15.754 1.00 14.92 ? 94  THR   B N    1 
ATOM   3680 C  CA   . THR   B 1 114 ? -15.255 14.867 15.078 1.00 15.86 ? 94  THR   B CA   1 
ATOM   3681 C  C    . THR   B 1 114 ? -16.172 14.096 14.133 1.00 20.13 ? 94  THR   B C    1 
ATOM   3682 O  O    . THR   B 1 114 ? -17.368 14.374 14.016 1.00 19.01 ? 94  THR   B O    1 
ATOM   3683 C  CB   . THR   B 1 114 ? -14.589 13.869 16.039 1.00 13.53 ? 94  THR   B CB   1 
ATOM   3684 O  OG1  . THR   B 1 114 ? -15.563 12.985 16.606 1.00 14.87 ? 94  THR   B OG1  1 
ATOM   3685 C  CG2  . THR   B 1 114 ? -13.846 14.591 17.156 1.00 14.72 ? 94  THR   B CG2  1 
ATOM   3686 H  H    . THR   B 1 114 ? -16.762 15.665 16.081 1.00 17.92 ? 94  THR   B H    1 
ATOM   3687 H  HA   . THR   B 1 114 ? -14.565 15.276 14.541 1.00 19.05 ? 94  THR   B HA   1 
ATOM   3688 H  HB   . THR   B 1 114 ? -13.941 13.344 15.544 1.00 16.25 ? 94  THR   B HB   1 
ATOM   3689 H  HG1  . THR   B 1 114 ? -16.137 13.426 17.033 1.00 17.86 ? 94  THR   B HG1  1 
ATOM   3690 H  HG21 . THR   B 1 114 ? -13.377 13.948 17.711 1.00 17.68 ? 94  THR   B HG21 1 
ATOM   3691 H  HG22 . THR   B 1 114 ? -13.203 15.211 16.779 1.00 17.68 ? 94  THR   B HG22 1 
ATOM   3692 H  HG23 . THR   B 1 114 ? -14.473 15.084 17.707 1.00 17.68 ? 94  THR   B HG23 1 
ATOM   3693 N  N    . GLN   B 1 115 ? -15.589 13.095 13.471 1.00 16.12 ? 95  GLN   B N    1 
ATOM   3694 C  CA   . GLN   B 1 115 ? -16.371 12.230 12.598 1.00 16.04 ? 95  GLN   B CA   1 
ATOM   3695 C  C    . GLN   B 1 115 ? -17.388 11.416 13.386 1.00 17.35 ? 95  GLN   B C    1 
ATOM   3696 O  O    . GLN   B 1 115 ? -18.365 10.934 12.805 1.00 19.74 ? 95  GLN   B O    1 
ATOM   3697 C  CB   . GLN   B 1 115 ? -15.442 11.316 11.786 1.00 18.38 ? 95  GLN   B CB   1 
ATOM   3698 C  CG   . GLN   B 1 115 ? -14.765 10.198 12.543 1.00 19.85 ? 95  GLN   B CG   1 
ATOM   3699 C  CD   . GLN   B 1 115 ? -13.403 10.591 13.070 1.00 17.33 ? 95  GLN   B CD   1 
ATOM   3700 O  OE1  . GLN   B 1 115 ? -13.156 11.756 13.383 1.00 17.70 ? 95  GLN   B OE1  1 
ATOM   3701 N  NE2  . GLN   B 1 115 ? -12.499 9.620  13.157 1.00 23.68 ? 95  GLN   B NE2  1 
ATOM   3702 H  H    . GLN   B 1 115 ? -14.752 12.900 13.511 1.00 19.37 ? 95  GLN   B H    1 
ATOM   3703 H  HA   . GLN   B 1 115 ? -16.861 12.784 11.970 1.00 19.27 ? 95  GLN   B HA   1 
ATOM   3704 H  HB2  . GLN   B 1 115 ? -15.963 10.908 11.076 1.00 22.07 ? 95  GLN   B HB2  1 
ATOM   3705 H  HB3  . GLN   B 1 115 ? -14.743 11.864 11.396 1.00 22.07 ? 95  GLN   B HB3  1 
ATOM   3706 H  HG2  . GLN   B 1 115 ? -15.309 9.930  13.299 1.00 23.84 ? 95  GLN   B HG2  1 
ATOM   3707 H  HG3  . GLN   B 1 115 ? -14.644 9.445  11.944 1.00 23.84 ? 95  GLN   B HG3  1 
ATOM   3708 H  HE21 . GLN   B 1 115 ? -12.706 8.818  12.927 1.00 28.44 ? 95  GLN   B HE21 1 
ATOM   3709 H  HE22 . GLN   B 1 115 ? -11.709 9.793  13.450 1.00 28.44 ? 95  GLN   B HE22 1 
ATOM   3710 N  N    . ASP   B 1 116 ? -17.181 11.263 14.697 1.00 17.10 ? 96  ASP   B N    1 
ATOM   3711 C  CA   . ASP   B 1 116 ? -18.147 10.624 15.587 1.00 17.56 ? 96  ASP   B CA   1 
ATOM   3712 C  C    . ASP   B 1 116 ? -19.052 11.712 16.150 1.00 16.67 ? 96  ASP   B C    1 
ATOM   3713 O  O    . ASP   B 1 116 ? -18.569 12.568 16.905 1.00 16.80 ? 96  ASP   B O    1 
ATOM   3714 C  CB   . ASP   B 1 116 ? -17.412 9.896  16.708 1.00 21.34 ? 96  ASP   B CB   1 
ATOM   3715 C  CG   . ASP   B 1 116 ? -18.334 9.097  17.612 1.00 21.42 ? 96  ASP   B CG   1 
ATOM   3716 O  OD1  . ASP   B 1 116 ? -19.555 9.369  17.641 1.00 21.70 ? 96  ASP   B OD1  1 
ATOM   3717 O  OD2  . ASP   B 1 116 ? -17.817 8.195  18.307 1.00 23.53 ? 96  ASP   B OD2  1 
ATOM   3718 H  H    . ASP   B 1 116 ? -16.470 11.528 15.102 1.00 20.54 ? 96  ASP   B H    1 
ATOM   3719 H  HA   . ASP   B 1 116 ? -18.673 9.979  15.091 1.00 21.09 ? 96  ASP   B HA   1 
ATOM   3720 H  HB2  . ASP   B 1 116 ? -16.772 9.281  16.316 1.00 25.63 ? 96  ASP   B HB2  1 
ATOM   3721 H  HB3  . ASP   B 1 116 ? -16.950 10.549 17.256 1.00 25.63 ? 96  ASP   B HB3  1 
ATOM   3722 N  N    . PRO   B 1 117 ? -20.343 11.748 15.806 1.00 17.61 ? 97  PRO   B N    1 
ATOM   3723 C  CA   . PRO   B 1 117 ? -21.193 12.830 16.333 1.00 17.04 ? 97  PRO   B CA   1 
ATOM   3724 C  C    . PRO   B 1 117 ? -21.270 12.821 17.850 1.00 15.84 ? 97  PRO   B C    1 
ATOM   3725 O  O    . PRO   B 1 117 ? -21.685 13.817 18.452 1.00 16.64 ? 97  PRO   B O    1 
ATOM   3726 C  CB   . PRO   B 1 117 ? -22.560 12.557 15.698 1.00 20.28 ? 97  PRO   B CB   1 
ATOM   3727 C  CG   . PRO   B 1 117 ? -22.554 11.094 15.404 1.00 21.49 ? 97  PRO   B CG   1 
ATOM   3728 C  CD   . PRO   B 1 117 ? -21.127 10.768 15.022 1.00 22.25 ? 97  PRO   B CD   1 
ATOM   3729 H  HA   . PRO   B 1 117 ? -20.866 13.692 16.033 1.00 20.47 ? 97  PRO   B HA   1 
ATOM   3730 H  HB2  . PRO   B 1 117 ? -23.264 12.779 16.327 1.00 24.35 ? 97  PRO   B HB2  1 
ATOM   3731 H  HB3  . PRO   B 1 117 ? -22.651 13.072 14.881 1.00 24.35 ? 97  PRO   B HB3  1 
ATOM   3732 H  HG2  . PRO   B 1 117 ? -22.817 10.601 16.197 1.00 25.81 ? 97  PRO   B HG2  1 
ATOM   3733 H  HG3  . PRO   B 1 117 ? -23.157 10.907 14.668 1.00 25.81 ? 97  PRO   B HG3  1 
ATOM   3734 H  HD2  . PRO   B 1 117 ? -20.905 9.862  15.289 1.00 26.72 ? 97  PRO   B HD2  1 
ATOM   3735 H  HD3  . PRO   B 1 117 ? -20.990 10.905 14.072 1.00 26.72 ? 97  PRO   B HD3  1 
ATOM   3736 N  N    . ASN   B 1 118 ? -20.874 11.723 18.485 1.00 16.69 ? 98  ASN   B N    1 
ATOM   3737 C  CA   . ASN   B 1 118 ? -20.941 11.585 19.930 1.00 15.29 ? 98  ASN   B CA   1 
ATOM   3738 C  C    . ASN   B 1 118 ? -19.578 11.735 20.595 1.00 15.13 ? 98  ASN   B C    1 
ATOM   3739 O  O    . ASN   B 1 118 ? -19.426 11.363 21.766 1.00 17.80 ? 98  ASN   B O    1 
ATOM   3740 C  CB   . ASN   B 1 118 ? -21.567 10.236 20.275 1.00 16.05 ? 98  ASN   B CB   1 
ATOM   3741 C  CG   . ASN   B 1 118 ? -23.049 10.202 19.994 1.00 16.02 ? 98  ASN   B CG   1 
ATOM   3742 O  OD1  . ASN   B 1 118 ? -23.804 11.030 20.495 1.00 24.02 ? 98  ASN   B OD1  1 
ATOM   3743 N  ND2  . ASN   B 1 118 ? -23.476 9.255  19.164 1.00 26.06 ? 98  ASN   B ND2  1 
ATOM   3744 H  H    . ASN   B 1 118 ? -20.558 11.027 18.091 1.00 20.04 ? 98  ASN   B H    1 
ATOM   3745 H  HA   . ASN   B 1 118 ? -21.520 12.277 20.286 1.00 18.37 ? 98  ASN   B HA   1 
ATOM   3746 H  HB2  . ASN   B 1 118 ? -21.143 9.544  19.743 1.00 19.28 ? 98  ASN   B HB2  1 
ATOM   3747 H  HB3  . ASN   B 1 118 ? -21.436 10.057 21.219 1.00 19.28 ? 98  ASN   B HB3  1 
ATOM   3748 H  HD21 . ASN   B 1 118 ? -24.312 9.197  18.972 1.00 31.29 ? 98  ASN   B HD21 1 
ATOM   3749 H  HD22 . ASN   B 1 118 ? -22.918 8.694  18.828 1.00 31.29 ? 98  ASN   B HD22 1 
ATOM   3750 N  N    . TRP   B 1 119 ? -18.586 12.283 19.891 1.00 15.74 ? 99  TRP   B N    1 
ATOM   3751 C  CA   . TRP   B 1 119 ? -17.257 12.475 20.466 1.00 14.02 ? 99  TRP   B CA   1 
ATOM   3752 C  C    . TRP   B 1 119 ? -16.737 13.851 20.083 1.00 14.95 ? 99  TRP   B C    1 
ATOM   3753 O  O    . TRP   B 1 119 ? -16.626 14.166 18.893 1.00 17.14 ? 99  TRP   B O    1 
ATOM   3754 C  CB   . TRP   B 1 119 ? -16.289 11.380 19.999 1.00 13.95 ? 99  TRP   B CB   1 
ATOM   3755 C  CG   . TRP   B 1 119 ? -15.120 11.143 20.916 1.00 14.25 ? 99  TRP   B CG   1 
ATOM   3756 C  CD1  . TRP   B 1 119 ? -14.519 12.048 21.742 1.00 14.12 ? 99  TRP   B CD1  1 
ATOM   3757 C  CD2  . TRP   B 1 119 ? -14.414 9.909  21.097 1.00 14.05 ? 99  TRP   B CD2  1 
ATOM   3758 N  NE1  . TRP   B 1 119 ? -13.489 11.453 22.429 1.00 14.55 ? 99  TRP   B NE1  1 
ATOM   3759 C  CE2  . TRP   B 1 119 ? -13.407 10.138 22.050 1.00 12.64 ? 99  TRP   B CE2  1 
ATOM   3760 C  CE3  . TRP   B 1 119 ? -14.545 8.628  20.550 1.00 16.43 ? 99  TRP   B CE3  1 
ATOM   3761 C  CZ2  . TRP   B 1 119 ? -12.521 9.139  22.456 1.00 15.83 ? 99  TRP   B CZ2  1 
ATOM   3762 C  CZ3  . TRP   B 1 119 ? -13.664 7.640  20.953 1.00 18.46 ? 99  TRP   B CZ3  1 
ATOM   3763 C  CH2  . TRP   B 1 119 ? -12.671 7.899  21.901 1.00 20.14 ? 99  TRP   B CH2  1 
ATOM   3764 H  H    . TRP   B 1 119 ? -18.658 12.552 19.078 1.00 18.91 ? 99  TRP   B H    1 
ATOM   3765 H  HA   . TRP   B 1 119 ? -17.316 12.434 21.433 1.00 16.85 ? 99  TRP   B HA   1 
ATOM   3766 H  HB2  . TRP   B 1 119 ? -16.778 10.546 19.925 1.00 16.76 ? 99  TRP   B HB2  1 
ATOM   3767 H  HB3  . TRP   B 1 119 ? -15.935 11.629 19.131 1.00 16.76 ? 99  TRP   B HB3  1 
ATOM   3768 H  HD1  . TRP   B 1 119 ? -14.776 12.937 21.834 1.00 16.96 ? 99  TRP   B HD1  1 
ATOM   3769 H  HE1  . TRP   B 1 119 ? -12.977 11.842 23.000 1.00 17.48 ? 99  TRP   B HE1  1 
ATOM   3770 H  HE3  . TRP   B 1 119 ? -15.203 8.447  19.918 1.00 19.74 ? 99  TRP   B HE3  1 
ATOM   3771 H  HZ2  . TRP   B 1 119 ? -11.858 9.309  23.086 1.00 19.01 ? 99  TRP   B HZ2  1 
ATOM   3772 H  HZ3  . TRP   B 1 119 ? -13.743 6.785  20.596 1.00 22.17 ? 99  TRP   B HZ3  1 
ATOM   3773 H  HH2  . TRP   B 1 119 ? -12.097 7.214  22.157 1.00 24.19 ? 99  TRP   B HH2  1 
ATOM   3774 N  N    . PHE   B 1 120 ? -16.413 14.654 21.097 1.00 13.67 ? 100 PHE   B N    1 
ATOM   3775 C  CA   . PHE   B 1 120 ? -15.892 16.003 20.938 1.00 12.97 ? 100 PHE   B CA   1 
ATOM   3776 C  C    . PHE   B 1 120 ? -14.585 16.123 21.704 1.00 12.77 ? 100 PHE   B C    1 
ATOM   3777 O  O    . PHE   B 1 120 ? -14.384 15.451 22.719 1.00 14.93 ? 100 PHE   B O    1 
ATOM   3778 C  CB   . PHE   B 1 120 ? -16.874 17.068 21.486 1.00 15.17 ? 100 PHE   B CB   1 
ATOM   3779 C  CG   . PHE   B 1 120 ? -18.071 17.289 20.618 1.00 14.85 ? 100 PHE   B CG   1 
ATOM   3780 C  CD1  . PHE   B 1 120 ? -19.063 16.328 20.530 1.00 18.94 ? 100 PHE   B CD1  1 
ATOM   3781 C  CD2  . PHE   B 1 120 ? -18.205 18.460 19.896 1.00 15.61 ? 100 PHE   B CD2  1 
ATOM   3782 C  CE1  . PHE   B 1 120 ? -20.164 16.525 19.728 1.00 18.42 ? 100 PHE   B CE1  1 
ATOM   3783 C  CE2  . PHE   B 1 120 ? -19.311 18.667 19.095 1.00 16.60 ? 100 PHE   B CE2  1 
ATOM   3784 C  CZ   . PHE   B 1 120 ? -20.287 17.696 19.008 1.00 15.19 ? 100 PHE   B CZ   1 
ATOM   3785 H  H    . PHE   B 1 120 ? -16.492 14.423 21.922 1.00 16.43 ? 100 PHE   B H    1 
ATOM   3786 H  HA   . PHE   B 1 120 ? -15.724 16.185 20.000 1.00 15.58 ? 100 PHE   B HA   1 
ATOM   3787 H  HB2  . PHE   B 1 120 ? -17.189 16.783 22.358 1.00 18.23 ? 100 PHE   B HB2  1 
ATOM   3788 H  HB3  . PHE   B 1 120 ? -16.405 17.914 21.566 1.00 18.23 ? 100 PHE   B HB3  1 
ATOM   3789 H  HD1  . PHE   B 1 120 ? -18.980 15.536 21.010 1.00 22.75 ? 100 PHE   B HD1  1 
ATOM   3790 H  HD2  . PHE   B 1 120 ? -17.546 19.114 19.950 1.00 18.75 ? 100 PHE   B HD2  1 
ATOM   3791 H  HE1  . PHE   B 1 120 ? -20.824 15.872 19.674 1.00 22.12 ? 100 PHE   B HE1  1 
ATOM   3792 H  HE2  . PHE   B 1 120 ? -19.394 19.456 18.609 1.00 19.94 ? 100 PHE   B HE2  1 
ATOM   3793 H  HZ   . PHE   B 1 120 ? -21.033 17.834 18.470 1.00 18.24 ? 100 PHE   B HZ   1 
ATOM   3794 N  N    . TRP   B 1 121 ? -13.705 17.000 21.227 1.00 11.21 ? 101 TRP   B N    1 
ATOM   3795 C  CA   . TRP   B 1 121 ? -12.531 17.413 21.981 1.00 11.33 ? 101 TRP   B CA   1 
ATOM   3796 C  C    . TRP   B 1 121 ? -12.568 18.924 22.159 1.00 11.64 ? 101 TRP   B C    1 
ATOM   3797 O  O    . TRP   B 1 121 ? -13.117 19.650 21.325 1.00 16.01 ? 101 TRP   B O    1 
ATOM   3798 C  CB   . TRP   B 1 121 ? -11.222 16.998 21.284 1.00 12.11 ? 101 TRP   B CB   1 
ATOM   3799 C  CG   . TRP   B 1 121 ? -11.015 15.526 21.303 1.00 10.09 ? 101 TRP   B CG   1 
ATOM   3800 C  CD1  . TRP   B 1 121 ? -11.504 14.627 20.407 1.00 12.00 ? 101 TRP   B CD1  1 
ATOM   3801 C  CD2  . TRP   B 1 121 ? -10.278 14.771 22.270 1.00 10.48 ? 101 TRP   B CD2  1 
ATOM   3802 N  NE1  . TRP   B 1 121 ? -11.116 13.357 20.750 1.00 14.56 ? 101 TRP   B NE1  1 
ATOM   3803 C  CE2  . TRP   B 1 121 ? -10.360 13.417 21.888 1.00 11.99 ? 101 TRP   B CE2  1 
ATOM   3804 C  CE3  . TRP   B 1 121 ? -9.548  15.107 23.415 1.00 12.71 ? 101 TRP   B CE3  1 
ATOM   3805 C  CZ2  . TRP   B 1 121 ? -9.744  12.401 22.610 1.00 12.03 ? 101 TRP   B CZ2  1 
ATOM   3806 C  CZ3  . TRP   B 1 121 ? -8.939  14.103 24.131 1.00 11.54 ? 101 TRP   B CZ3  1 
ATOM   3807 C  CH2  . TRP   B 1 121 ? -9.044  12.762 23.726 1.00 12.19 ? 101 TRP   B CH2  1 
ATOM   3808 H  H    . TRP   B 1 121 ? -13.770 17.375 20.456 1.00 13.47 ? 101 TRP   B H    1 
ATOM   3809 H  HA   . TRP   B 1 121 ? -12.552 17.002 22.858 1.00 13.62 ? 101 TRP   B HA   1 
ATOM   3810 H  HB2  . TRP   B 1 121 ? -11.250 17.287 20.358 1.00 14.55 ? 101 TRP   B HB2  1 
ATOM   3811 H  HB3  . TRP   B 1 121 ? -10.474 17.414 21.740 1.00 14.55 ? 101 TRP   B HB3  1 
ATOM   3812 H  HD1  . TRP   B 1 121 ? -12.029 14.842 19.670 1.00 14.41 ? 101 TRP   B HD1  1 
ATOM   3813 H  HE1  . TRP   B 1 121 ? -11.314 12.640 20.318 1.00 17.50 ? 101 TRP   B HE1  1 
ATOM   3814 H  HE3  . TRP   B 1 121 ? -9.477  15.993 23.688 1.00 15.26 ? 101 TRP   B HE3  1 
ATOM   3815 H  HZ2  . TRP   B 1 121 ? -9.809  11.512 22.346 1.00 14.45 ? 101 TRP   B HZ2  1 
ATOM   3816 H  HZ3  . TRP   B 1 121 ? -8.454  14.314 24.896 1.00 13.86 ? 101 TRP   B HZ3  1 
ATOM   3817 H  HH2  . TRP   B 1 121 ? -8.621  12.103 24.228 1.00 14.65 ? 101 TRP   B HH2  1 
ATOM   3818 N  N    . VAL   B 1 122 ? -11.985 19.387 23.257 1.00 12.75 ? 102 VAL   B N    1 
ATOM   3819 C  CA   . VAL   B 1 122 ? -11.884 20.811 23.554 1.00 11.39 ? 102 VAL   B CA   1 
ATOM   3820 C  C    . VAL   B 1 122 ? -10.445 21.126 23.924 1.00 13.43 ? 102 VAL   B C    1 
ATOM   3821 O  O    . VAL   B 1 122 ? -9.867  20.452 24.781 1.00 14.21 ? 102 VAL   B O    1 
ATOM   3822 C  CB   . VAL   B 1 122 ? -12.818 21.222 24.708 1.00 15.45 ? 102 VAL   B CB   1 
ATOM   3823 C  CG1  . VAL   B 1 122 ? -12.656 22.701 24.995 1.00 15.85 ? 102 VAL   B CG1  1 
ATOM   3824 C  CG2  . VAL   B 1 122 ? -14.253 20.876 24.381 1.00 17.35 ? 102 VAL   B CG2  1 
ATOM   3825 H  H    . VAL   B 1 122 ? -11.632 18.885 23.860 1.00 15.32 ? 102 VAL   B H    1 
ATOM   3826 H  HA   . VAL   B 1 122 ? -12.120 21.326 22.767 1.00 13.69 ? 102 VAL   B HA   1 
ATOM   3827 H  HB   . VAL   B 1 122 ? -12.566 20.735 25.506 1.00 18.56 ? 102 VAL   B HB   1 
ATOM   3828 H  HG11 . VAL   B 1 122 ? -13.403 22.999 25.537 1.00 19.04 ? 102 VAL   B HG11 1 
ATOM   3829 H  HG12 . VAL   B 1 122 ? -11.825 22.844 25.474 1.00 19.04 ? 102 VAL   B HG12 1 
ATOM   3830 H  HG13 . VAL   B 1 122 ? -12.644 23.186 24.155 1.00 19.04 ? 102 VAL   B HG13 1 
ATOM   3831 H  HG21 . VAL   B 1 122 ? -14.824 21.186 25.101 1.00 20.84 ? 102 VAL   B HG21 1 
ATOM   3832 H  HG22 . VAL   B 1 122 ? -14.501 21.312 23.551 1.00 20.84 ? 102 VAL   B HG22 1 
ATOM   3833 H  HG23 . VAL   B 1 122 ? -14.333 19.914 24.287 1.00 20.84 ? 102 VAL   B HG23 1 
ATOM   3834 N  N    . GLU   B 1 123 ? -9.868  22.140 23.286 1.00 11.46 ? 103 GLU   B N    1 
ATOM   3835 C  CA   . GLU   B 1 123 ? -8.613  22.723 23.742 1.00 12.09 ? 103 GLU   B CA   1 
ATOM   3836 C  C    . GLU   B 1 123 ? -8.936  24.043 24.430 1.00 14.72 ? 103 GLU   B C    1 
ATOM   3837 O  O    . GLU   B 1 123 ? -9.703  24.853 23.895 1.00 14.18 ? 103 GLU   B O    1 
ATOM   3838 C  CB   . GLU   B 1 123 ? -7.626  22.945 22.600 1.00 10.46 ? 103 GLU   B CB   1 
ATOM   3839 C  CG   . GLU   B 1 123 ? -6.333  23.583 23.092 1.00 12.93 ? 103 GLU   B CG   1 
ATOM   3840 C  CD   . GLU   B 1 123 ? -5.240  23.667 22.045 1.00 17.89 ? 103 GLU   B CD   1 
ATOM   3841 O  OE1  . GLU   B 1 123 ? -5.513  23.501 20.832 1.00 15.12 ? 103 GLU   B OE1  1 
ATOM   3842 O  OE2  . GLU   B 1 123 ? -4.089  23.913 22.459 1.00 15.40 ? 103 GLU   B OE2  1 
ATOM   3843 H  H    . GLU   B 1 123 ? -10.188 22.511 22.579 1.00 13.77 ? 103 GLU   B H    1 
ATOM   3844 H  HA   . GLU   B 1 123 ? -8.198  22.134 24.392 1.00 14.52 ? 103 GLU   B HA   1 
ATOM   3845 H  HB2  . GLU   B 1 123 ? -7.408  22.091 22.195 1.00 12.57 ? 103 GLU   B HB2  1 
ATOM   3846 H  HB3  . GLU   B 1 123 ? -8.025  23.536 21.943 1.00 12.57 ? 103 GLU   B HB3  1 
ATOM   3847 H  HG2  . GLU   B 1 123 ? -6.521  24.487 23.387 1.00 15.53 ? 103 GLU   B HG2  1 
ATOM   3848 H  HG3  . GLU   B 1 123 ? -5.991  23.061 23.834 1.00 15.53 ? 103 GLU   B HG3  1 
ATOM   3849 N  N    . CYS   B 1 124 ? -8.378  24.253 25.616 1.00 13.47 ? 104 CYS   B N    1 
ATOM   3850 C  CA   . CYS   B 1 124 ? -8.680  25.479 26.340 1.00 12.17 ? 104 CYS   B CA   1 
ATOM   3851 C  C    . CYS   B 1 124 ? -7.593  25.744 27.372 1.00 15.20 ? 104 CYS   B C    1 
ATOM   3852 O  O    . CYS   B 1 124 ? -6.629  24.983 27.512 1.00 14.21 ? 104 CYS   B O    1 
ATOM   3853 C  CB   . CYS   B 1 124 ? -10.058 25.395 27.005 1.00 11.29 ? 104 CYS   B CB   1 
ATOM   3854 S  SG   . CYS   B 1 124 ? -10.096 24.217 28.375 1.00 15.05 ? 104 CYS   B SG   1 
ATOM   3855 H  H    . CYS   B 1 124 ? -7.836  23.717 26.014 1.00 16.19 ? 104 CYS   B H    1 
ATOM   3856 H  HA   . CYS   B 1 124 ? -8.691  26.222 25.717 1.00 14.63 ? 104 CYS   B HA   1 
ATOM   3857 H  HB2  . CYS   B 1 124 ? -10.296 26.268 27.354 1.00 13.56 ? 104 CYS   B HB2  1 
ATOM   3858 H  HB3  . CYS   B 1 124 ? -10.711 25.111 26.346 1.00 13.56 ? 104 CYS   B HB3  1 
ATOM   3859 H  HG   . CYS   B 1 124 ? -11.157 24.298 28.928 1.00 18.08 ? 104 CYS   B HG   1 
ATOM   3860 N  N    . ARG   B 1 125 ? -7.740  26.861 28.066 1.00 13.46 ? 105 ARG   B N    1 
ATOM   3861 C  CA   . ARG   B 1 125 ? -6.976  27.136 29.266 1.00 11.61 ? 105 ARG   B CA   1 
ATOM   3862 C  C    . ARG   B 1 125 ? -7.939  27.206 30.440 1.00 13.75 ? 105 ARG   B C    1 
ATOM   3863 O  O    . ARG   B 1 125 ? -9.158  27.311 30.271 1.00 15.61 ? 105 ARG   B O    1 
ATOM   3864 C  CB   . ARG   B 1 125 ? -6.160  28.422 29.120 1.00 14.07 ? 105 ARG   B CB   1 
ATOM   3865 C  CG   . ARG   B 1 125 ? -5.059  28.288 28.065 1.00 18.82 ? 105 ARG   B CG   1 
ATOM   3866 C  CD   . ARG   B 1 125 ? -4.084  29.448 28.104 1.00 29.40 ? 105 ARG   B CD   1 
ATOM   3867 N  NE   . ARG   B 1 125 ? -3.505  29.563 29.434 1.00 42.42 ? 105 ARG   B NE   1 
ATOM   3868 C  CZ   . ARG   B 1 125 ? -2.453  28.878 29.860 1.00 45.11 ? 105 ARG   B CZ   1 
ATOM   3869 N  NH1  . ARG   B 1 125 ? -1.757  28.099 29.045 1.00 30.12 ? 105 ARG   B NH1  1 
ATOM   3870 N  NH2  . ARG   B 1 125 ? -2.095  28.970 31.137 1.00 29.94 ? 105 ARG   B NH2  1 
ATOM   3871 H  H    . ARG   B 1 125 ? -8.289  27.488 27.856 1.00 16.17 ? 105 ARG   B H    1 
ATOM   3872 H  HA   . ARG   B 1 125 ? -6.359  26.406 29.428 1.00 13.95 ? 105 ARG   B HA   1 
ATOM   3873 H  HB2  . ARG   B 1 125 ? -6.750  29.143 28.850 1.00 16.91 ? 105 ARG   B HB2  1 
ATOM   3874 H  HB3  . ARG   B 1 125 ? -5.747  28.629 29.972 1.00 16.91 ? 105 ARG   B HB3  1 
ATOM   3875 H  HG2  . ARG   B 1 125 ? -4.562  27.471 28.226 1.00 22.61 ? 105 ARG   B HG2  1 
ATOM   3876 H  HG3  . ARG   B 1 125 ? -5.464  28.264 27.184 1.00 22.61 ? 105 ARG   B HG3  1 
ATOM   3877 H  HD2  . ARG   B 1 125 ? -3.374  29.303 27.460 1.00 35.30 ? 105 ARG   B HD2  1 
ATOM   3878 H  HD3  . ARG   B 1 125 ? -4.556  30.271 27.905 1.00 35.30 ? 105 ARG   B HD3  1 
ATOM   3879 H  HE   . ARG   B 1 125 ? -3.871  30.115 29.983 1.00 50.92 ? 105 ARG   B HE   1 
ATOM   3880 H  HH11 . ARG   B 1 125 ? -1.981  28.025 28.219 1.00 36.17 ? 105 ARG   B HH11 1 
ATOM   3881 H  HH12 . ARG   B 1 125 ? -1.077  27.665 29.345 1.00 36.17 ? 105 ARG   B HH12 1 
ATOM   3882 H  HH21 . ARG   B 1 125 ? -2.539  29.476 31.673 1.00 35.94 ? 105 ARG   B HH21 1 
ATOM   3883 H  HH22 . ARG   B 1 125 ? -1.410  28.536 31.424 1.00 35.94 ? 105 ARG   B HH22 1 
ATOM   3884 N  N    . GLY   B 1 126 ? -7.380  27.100 31.631 1.00 14.74 ? 106 GLY   B N    1 
ATOM   3885 C  CA   . GLY   B 1 126 ? -8.161  27.252 32.841 1.00 12.08 ? 106 GLY   B CA   1 
ATOM   3886 C  C    . GLY   B 1 126 ? -7.365  28.039 33.856 1.00 13.28 ? 106 GLY   B C    1 
ATOM   3887 O  O    . GLY   B 1 126 ? -6.132  27.999 33.873 1.00 14.39 ? 106 GLY   B O    1 
ATOM   3888 H  H    . GLY   B 1 126 ? -6.546  26.940 31.766 1.00 17.70 ? 106 GLY   B H    1 
ATOM   3889 H  HA2  . GLY   B 1 126 ? -8.985  27.726 32.650 1.00 14.51 ? 106 GLY   B HA2  1 
ATOM   3890 H  HA3  . GLY   B 1 126 ? -8.375  26.381 33.208 1.00 14.51 ? 106 GLY   B HA3  1 
ATOM   3891 N  N    . GLU   B 1 127 ? -8.082  28.775 34.698 1.00 13.09 ? 107 GLU   B N    1 
ATOM   3892 C  CA   . GLU   B 1 127 ? -7.411  29.584 35.699 1.00 12.89 ? 107 GLU   B CA   1 
ATOM   3893 C  C    . GLU   B 1 127 ? -8.297  29.801 36.914 1.00 13.51 ? 107 GLU   B C    1 
ATOM   3894 O  O    . GLU   B 1 127 ? -9.518  29.927 36.801 1.00 15.32 ? 107 GLU   B O    1 
ATOM   3895 C  CB   . GLU   B 1 127 ? -7.011  30.950 35.128 1.00 16.27 ? 107 GLU   B CB   1 
ATOM   3896 C  CG   . GLU   B 1 127 ? -8.189  31.742 34.604 1.00 18.64 ? 107 GLU   B CG   1 
ATOM   3897 C  CD   . GLU   B 1 127 ? -7.862  33.205 34.439 1.00 26.94 ? 107 GLU   B CD   1 
ATOM   3898 O  OE1  . GLU   B 1 127 ? -7.126  33.544 33.488 1.00 30.30 ? 107 GLU   B OE1  1 
ATOM   3899 O  OE2  . GLU   B 1 127 ? -8.325  34.011 35.268 1.00 32.21 ? 107 GLU   B OE2  1 
ATOM   3900 H  H    . GLU   B 1 127 ? -8.941  28.822 34.709 1.00 15.73 ? 107 GLU   B H    1 
ATOM   3901 H  HA   . GLU   B 1 127 ? -6.606  29.129 35.987 1.00 15.49 ? 107 GLU   B HA   1 
ATOM   3902 H  HB2  . GLU   B 1 127 ? -6.587  31.472 35.827 1.00 19.54 ? 107 GLU   B HB2  1 
ATOM   3903 H  HB3  . GLU   B 1 127 ? -6.391  30.815 34.394 1.00 19.54 ? 107 GLU   B HB3  1 
ATOM   3904 H  HG2  . GLU   B 1 127 ? -8.444  31.392 33.736 1.00 22.38 ? 107 GLU   B HG2  1 
ATOM   3905 H  HG3  . GLU   B 1 127 ? -8.933  31.674 35.221 1.00 22.38 ? 107 GLU   B HG3  1 
ATOM   3906 N  N    . GLY   B 1 128 ? -7.659  29.907 38.071 1.00 17.01 ? 108 GLY   B N    1 
ATOM   3907 C  CA   . GLY   B 1 128 ? -8.382  30.276 39.271 1.00 15.29 ? 108 GLY   B CA   1 
ATOM   3908 C  C    . GLY   B 1 128 ? -7.518  30.056 40.486 1.00 15.62 ? 108 GLY   B C    1 
ATOM   3909 O  O    . GLY   B 1 128 ? -6.411  29.518 40.408 1.00 16.82 ? 108 GLY   B O    1 
ATOM   3910 H  H    . GLY   B 1 128 ? -6.817  29.772 38.185 1.00 20.43 ? 108 GLY   B H    1 
ATOM   3911 H  HA2  . GLY   B 1 128 ? -8.635  31.211 39.230 1.00 18.37 ? 108 GLY   B HA2  1 
ATOM   3912 H  HA3  . GLY   B 1 128 ? -9.184  29.736 39.353 1.00 18.37 ? 108 GLY   B HA3  1 
ATOM   3913 N  N    . ALA   B 1 129 ? -8.038  30.504 41.621 1.00 17.33 ? 109 ALA   B N    1 
ATOM   3914 C  CA   . ALA   B 1 129 ? -7.394  30.192 42.885 1.00 18.05 ? 109 ALA   B CA   1 
ATOM   3915 C  C    . ALA   B 1 129 ? -7.409  28.685 43.099 1.00 15.25 ? 109 ALA   B C    1 
ATOM   3916 O  O    . ALA   B 1 129 ? -8.348  27.988 42.708 1.00 16.27 ? 109 ALA   B O    1 
ATOM   3917 C  CB   . ALA   B 1 129 ? -8.106  30.889 44.040 1.00 18.25 ? 109 ALA   B CB   1 
ATOM   3918 H  H    . ALA   B 1 129 ? -8.750  30.982 41.686 1.00 20.81 ? 109 ALA   B H    1 
ATOM   3919 H  HA   . ALA   B 1 129 ? -6.472  30.493 42.863 1.00 21.68 ? 109 ALA   B HA   1 
ATOM   3920 H  HB1  . ALA   B 1 129 ? -7.656  30.664 44.869 1.00 21.92 ? 109 ALA   B HB1  1 
ATOM   3921 H  HB2  . ALA   B 1 129 ? -8.076  31.848 43.896 1.00 21.92 ? 109 ALA   B HB2  1 
ATOM   3922 H  HB3  . ALA   B 1 129 ? -9.027  30.588 44.070 1.00 21.92 ? 109 ALA   B HB3  1 
ATOM   3923 N  N    . ILE   B 1 130 ? -6.351  28.176 43.723 1.00 17.02 ? 110 ILE   B N    1 
ATOM   3924 C  CA   . ILE   B 1 130 ? -6.304  26.782 44.149 1.00 14.92 ? 110 ILE   B CA   1 
ATOM   3925 C  C    . ILE   B 1 130 ? -6.194  26.774 45.668 1.00 16.70 ? 110 ILE   B C    1 
ATOM   3926 O  O    . ILE   B 1 130 ? -5.288  27.396 46.241 1.00 16.46 ? 110 ILE   B O    1 
ATOM   3927 C  CB   . ILE   B 1 130 ? -5.163  25.994 43.478 1.00 14.66 ? 110 ILE   B CB   1 
ATOM   3928 C  CG1  . ILE   B 1 130 ? -5.236  24.528 43.926 1.00 15.27 ? 110 ILE   B CG1  1 
ATOM   3929 C  CG2  . ILE   B 1 130 ? -3.780  26.597 43.743 1.00 16.25 ? 110 ILE   B CG2  1 
ATOM   3930 C  CD1  . ILE   B 1 130 ? -4.402  23.592 43.074 1.00 18.60 ? 110 ILE   B CD1  1 
ATOM   3931 H  H    . ILE   B 1 130 ? -5.641  28.622 43.913 1.00 20.44 ? 110 ILE   B H    1 
ATOM   3932 H  HA   . ILE   B 1 130 ? -7.139  26.349 43.912 1.00 17.92 ? 110 ILE   B HA   1 
ATOM   3933 H  HB   . ILE   B 1 130 ? -5.314  26.017 42.520 1.00 17.61 ? 110 ILE   B HB   1 
ATOM   3934 H  HG12 . ILE   B 1 130 ? -4.915  24.462 44.839 1.00 18.34 ? 110 ILE   B HG12 1 
ATOM   3935 H  HG13 . ILE   B 1 130 ? -6.158  24.231 43.879 1.00 18.34 ? 110 ILE   B HG13 1 
ATOM   3936 H  HG21 . ILE   B 1 130 ? -3.121  26.118 43.218 1.00 19.52 ? 110 ILE   B HG21 1 
ATOM   3937 H  HG22 . ILE   B 1 130 ? -3.790  27.532 43.487 1.00 19.52 ? 110 ILE   B HG22 1 
ATOM   3938 H  HG23 . ILE   B 1 130 ? -3.574  26.514 44.687 1.00 19.52 ? 110 ILE   B HG23 1 
ATOM   3939 H  HD11 . ILE   B 1 130 ? -4.535  22.682 43.383 1.00 22.34 ? 110 ILE   B HD11 1 
ATOM   3940 H  HD12 . ILE   B 1 130 ? -4.684  23.673 42.149 1.00 22.34 ? 110 ILE   B HD12 1 
ATOM   3941 H  HD13 . ILE   B 1 130 ? -3.467  23.837 43.158 1.00 22.34 ? 110 ILE   B HD13 1 
ATOM   3942 N  N    . VAL   B 1 131 ? -7.145  26.106 46.316 1.00 15.52 ? 111 VAL   B N    1 
ATOM   3943 C  CA   . VAL   B 1 131 ? -7.254  26.097 47.770 1.00 14.16 ? 111 VAL   B CA   1 
ATOM   3944 C  C    . VAL   B 1 131 ? -7.299  24.646 48.226 1.00 16.69 ? 111 VAL   B C    1 
ATOM   3945 O  O    . VAL   B 1 131 ? -8.369  24.122 48.561 1.00 20.90 ? 111 VAL   B O    1 
ATOM   3946 C  CB   . VAL   B 1 131 ? -8.502  26.865 48.239 1.00 18.92 ? 111 VAL   B CB   1 
ATOM   3947 C  CG1  . VAL   B 1 131 ? -8.494  26.995 49.752 1.00 23.83 ? 111 VAL   B CG1  1 
ATOM   3948 C  CG2  . VAL   B 1 131 ? -8.572  28.236 47.576 1.00 20.01 ? 111 VAL   B CG2  1 
ATOM   3949 H  H    . VAL   B 1 131 ? -7.753  25.640 45.925 1.00 18.64 ? 111 VAL   B H    1 
ATOM   3950 H  HA   . VAL   B 1 131 ? -6.471  26.517 48.159 1.00 17.01 ? 111 VAL   B HA   1 
ATOM   3951 H  HB   . VAL   B 1 131 ? -9.295  26.368 47.984 1.00 22.72 ? 111 VAL   B HB   1 
ATOM   3952 H  HG11 . VAL   B 1 131 ? -9.245  27.545 50.025 1.00 28.62 ? 111 VAL   B HG11 1 
ATOM   3953 H  HG12 . VAL   B 1 131 ? -8.570  26.113 50.147 1.00 28.62 ? 111 VAL   B HG12 1 
ATOM   3954 H  HG13 . VAL   B 1 131 ? -7.663  27.411 50.028 1.00 28.62 ? 111 VAL   B HG13 1 
ATOM   3955 H  HG21 . VAL   B 1 131 ? -9.168  28.806 48.087 1.00 24.04 ? 111 VAL   B HG21 1 
ATOM   3956 H  HG22 . VAL   B 1 131 ? -7.682  28.620 47.554 1.00 24.04 ? 111 VAL   B HG22 1 
ATOM   3957 H  HG23 . VAL   B 1 131 ? -8.906  28.131 46.671 1.00 24.04 ? 111 VAL   B HG23 1 
ATOM   3958 N  N    . PHE   B 1 132 ? -6.143  23.979 48.212 1.00 15.74 ? 112 PHE   B N    1 
ATOM   3959 C  CA   . PHE   B 1 132 ? -6.083  22.565 48.569 1.00 14.59 ? 112 PHE   B CA   1 
ATOM   3960 C  C    . PHE   B 1 132 ? -5.809  22.418 50.059 1.00 21.76 ? 112 PHE   B C    1 
ATOM   3961 O  O    . PHE   B 1 132 ? -5.056  23.210 50.632 1.00 19.99 ? 112 PHE   B O    1 
ATOM   3962 C  CB   . PHE   B 1 132 ? -4.993  21.840 47.786 1.00 16.58 ? 112 PHE   B CB   1 
ATOM   3963 C  CG   . PHE   B 1 132 ? -5.470  21.234 46.488 1.00 13.72 ? 112 PHE   B CG   1 
ATOM   3964 C  CD1  . PHE   B 1 132 ? -6.463  21.849 45.752 1.00 19.32 ? 112 PHE   B CD1  1 
ATOM   3965 C  CD2  . PHE   B 1 132 ? -4.927  20.050 46.012 1.00 19.34 ? 112 PHE   B CD2  1 
ATOM   3966 C  CE1  . PHE   B 1 132 ? -6.905  21.302 44.553 1.00 17.65 ? 112 PHE   B CE1  1 
ATOM   3967 C  CE2  . PHE   B 1 132 ? -5.366  19.494 44.812 1.00 21.73 ? 112 PHE   B CE2  1 
ATOM   3968 C  CZ   . PHE   B 1 132 ? -6.358  20.124 44.088 1.00 17.56 ? 112 PHE   B CZ   1 
ATOM   3969 H  H    . PHE   B 1 132 ? -5.384  24.323 48.000 1.00 18.91 ? 112 PHE   B H    1 
ATOM   3970 H  HA   . PHE   B 1 132 ? -6.935  22.161 48.355 1.00 17.52 ? 112 PHE   B HA   1 
ATOM   3971 H  HB2  . PHE   B 1 132 ? -4.287  22.471 47.576 1.00 19.91 ? 112 PHE   B HB2  1 
ATOM   3972 H  HB3  . PHE   B 1 132 ? -4.639  21.123 48.335 1.00 19.91 ? 112 PHE   B HB3  1 
ATOM   3973 H  HD1  . PHE   B 1 132 ? -6.836  22.644 46.058 1.00 23.21 ? 112 PHE   B HD1  1 
ATOM   3974 H  HD2  . PHE   B 1 132 ? -4.258  19.624 46.497 1.00 23.22 ? 112 PHE   B HD2  1 
ATOM   3975 H  HE1  . PHE   B 1 132 ? -7.574  21.727 44.067 1.00 21.20 ? 112 PHE   B HE1  1 
ATOM   3976 H  HE2  . PHE   B 1 132 ? -4.994  18.700 44.502 1.00 26.10 ? 112 PHE   B HE2  1 
ATOM   3977 H  HZ   . PHE   B 1 132 ? -6.655  19.756 43.287 1.00 21.09 ? 112 PHE   B HZ   1 
ATOM   3978 N  N    . PRO   B 1 133 ? -6.418  21.425 50.702 1.00 20.38 ? 113 PRO   B N    1 
ATOM   3979 C  CA   . PRO   B 1 133 ? -6.188  21.236 52.140 1.00 21.28 ? 113 PRO   B CA   1 
ATOM   3980 C  C    . PRO   B 1 133 ? -4.707  21.091 52.455 1.00 16.79 ? 113 PRO   B C    1 
ATOM   3981 O  O    . PRO   B 1 133 ? -4.020  20.230 51.904 1.00 19.02 ? 113 PRO   B O    1 
ATOM   3982 C  CB   . PRO   B 1 133 ? -6.962  19.949 52.458 1.00 17.66 ? 113 PRO   B CB   1 
ATOM   3983 C  CG   . PRO   B 1 133 ? -8.037  19.890 51.404 1.00 26.54 ? 113 PRO   B CG   1 
ATOM   3984 C  CD   . PRO   B 1 133 ? -7.392  20.457 50.160 1.00 25.92 ? 113 PRO   B CD   1 
ATOM   3985 H  HA   . PRO   B 1 133 ? -6.560  21.975 52.647 1.00 25.55 ? 113 PRO   B HA   1 
ATOM   3986 H  HB2  . PRO   B 1 133 ? -6.369  19.185 52.388 1.00 21.21 ? 113 PRO   B HB2  1 
ATOM   3987 H  HB3  . PRO   B 1 133 ? -7.348  20.006 53.346 1.00 21.21 ? 113 PRO   B HB3  1 
ATOM   3988 H  HG2  . PRO   B 1 133 ? -8.306  18.970 51.261 1.00 31.87 ? 113 PRO   B HG2  1 
ATOM   3989 H  HG3  . PRO   B 1 133 ? -8.794  20.432 51.677 1.00 31.87 ? 113 PRO   B HG3  1 
ATOM   3990 H  HD2  . PRO   B 1 133 ? -6.938  19.758 49.663 1.00 31.12 ? 113 PRO   B HD2  1 
ATOM   3991 H  HD3  . PRO   B 1 133 ? -8.062  20.904 49.620 1.00 31.12 ? 113 PRO   B HD3  1 
ATOM   3992 N  N    . GLY   B 1 134 ? -4.229  21.928 53.369 1.00 24.24 ? 114 GLY   B N    1 
ATOM   3993 C  CA   . GLY   B 1 134 ? -2.873  21.809 53.858 1.00 25.09 ? 114 GLY   B CA   1 
ATOM   3994 C  C    . GLY   B 1 134 ? -1.805  22.376 52.956 1.00 24.78 ? 114 GLY   B C    1 
ATOM   3995 O  O    . GLY   B 1 134 ? -0.621  22.105 53.181 1.00 25.45 ? 114 GLY   B O    1 
ATOM   3996 H  H    . GLY   B 1 134 ? -4.676  22.574 53.720 1.00 29.10 ? 114 GLY   B H    1 
ATOM   3997 H  HA2  . GLY   B 1 134 ? -2.809  22.261 54.714 1.00 30.13 ? 114 GLY   B HA2  1 
ATOM   3998 H  HA3  . GLY   B 1 134 ? -2.674  20.871 54.001 1.00 30.13 ? 114 GLY   B HA3  1 
ATOM   3999 N  N    . TYR   B 1 135 ? -2.171  23.134 51.939 1.00 16.58 ? 115 TYR   B N    1 
ATOM   4000 C  CA   . TYR   B 1 135 ? -1.239  23.852 51.087 1.00 19.16 ? 115 TYR   B CA   1 
ATOM   4001 C  C    . TYR   B 1 135 ? -1.552  25.337 51.174 1.00 21.23 ? 115 TYR   B C    1 
ATOM   4002 O  O    . TYR   B 1 135 ? -2.693  25.725 51.457 1.00 20.30 ? 115 TYR   B O    1 
ATOM   4003 C  CB   . TYR   B 1 135 ? -1.341  23.389 49.627 1.00 19.45 ? 115 TYR   B CB   1 
ATOM   4004 C  CG   . TYR   B 1 135 ? -0.783  22.010 49.388 1.00 16.55 ? 115 TYR   B CG   1 
ATOM   4005 C  CD1  . TYR   B 1 135 ? 0.554   21.832 49.060 1.00 17.92 ? 115 TYR   B CD1  1 
ATOM   4006 C  CD2  . TYR   B 1 135 ? -1.586  20.887 49.487 1.00 17.42 ? 115 TYR   B CD2  1 
ATOM   4007 C  CE1  . TYR   B 1 135 ? 1.073   20.577 48.851 1.00 20.63 ? 115 TYR   B CE1  1 
ATOM   4008 C  CE2  . TYR   B 1 135 ? -1.073  19.624 49.272 1.00 16.45 ? 115 TYR   B CE2  1 
ATOM   4009 C  CZ   . TYR   B 1 135 ? 0.256   19.476 48.950 1.00 18.93 ? 115 TYR   B CZ   1 
ATOM   4010 O  OH   . TYR   B 1 135 ? 0.786   18.225 48.740 1.00 18.45 ? 115 TYR   B OH   1 
ATOM   4011 H  H    . TYR   B 1 135 ? -2.992  23.254 51.712 1.00 19.91 ? 115 TYR   B H    1 
ATOM   4012 H  HA   . TYR   B 1 135 ? -0.334  23.699 51.399 1.00 23.01 ? 115 TYR   B HA   1 
ATOM   4013 H  HB2  . TYR   B 1 135 ? -2.275  23.380 49.366 1.00 23.36 ? 115 TYR   B HB2  1 
ATOM   4014 H  HB3  . TYR   B 1 135 ? -0.849  24.009 49.067 1.00 23.36 ? 115 TYR   B HB3  1 
ATOM   4015 H  HD1  . TYR   B 1 135 ? 1.111   22.574 48.992 1.00 21.53 ? 115 TYR   B HD1  1 
ATOM   4016 H  HD2  . TYR   B 1 135 ? -2.485  20.985 49.704 1.00 20.92 ? 115 TYR   B HD2  1 
ATOM   4017 H  HE1  . TYR   B 1 135 ? 1.971   20.474 48.632 1.00 24.77 ? 115 TYR   B HE1  1 
ATOM   4018 H  HE2  . TYR   B 1 135 ? -1.623  18.877 49.343 1.00 19.76 ? 115 TYR   B HE2  1 
ATOM   4019 H  HH   . TYR   B 1 135 ? 1.605   18.286 48.563 1.00 22.15 ? 115 TYR   B HH   1 
ATOM   4020 N  N    . PRO   B 1 136 ? -0.574  26.206 50.921 1.00 21.38 ? 116 PRO   B N    1 
ATOM   4021 C  CA   . PRO   B 1 136 ? -0.896  27.636 50.851 1.00 21.74 ? 116 PRO   B CA   1 
ATOM   4022 C  C    . PRO   B 1 136 ? -1.844  27.895 49.692 1.00 25.42 ? 116 PRO   B C    1 
ATOM   4023 O  O    . PRO   B 1 136 ? -1.799  27.217 48.665 1.00 22.06 ? 116 PRO   B O    1 
ATOM   4024 C  CB   . PRO   B 1 136 ? 0.464   28.311 50.627 1.00 21.66 ? 116 PRO   B CB   1 
ATOM   4025 C  CG   . PRO   B 1 136 ? 1.489   27.266 50.952 1.00 29.40 ? 116 PRO   B CG   1 
ATOM   4026 C  CD   . PRO   B 1 136 ? 0.846   25.950 50.611 1.00 24.28 ? 116 PRO   B CD   1 
ATOM   4027 H  HA   . PRO   B 1 136 ? -1.290  27.946 51.681 1.00 26.10 ? 116 PRO   B HA   1 
ATOM   4028 H  HB2  . PRO   B 1 136 ? 0.541   28.589 49.701 1.00 26.01 ? 116 PRO   B HB2  1 
ATOM   4029 H  HB3  . PRO   B 1 136 ? 0.552   29.072 51.222 1.00 26.01 ? 116 PRO   B HB3  1 
ATOM   4030 H  HG2  . PRO   B 1 136 ? 2.282   27.409 50.412 1.00 35.30 ? 116 PRO   B HG2  1 
ATOM   4031 H  HG3  . PRO   B 1 136 ? 1.706   27.306 51.897 1.00 35.30 ? 116 PRO   B HG3  1 
ATOM   4032 H  HD2  . PRO   B 1 136 ? 0.959   25.748 49.669 1.00 29.15 ? 116 PRO   B HD2  1 
ATOM   4033 H  HD3  . PRO   B 1 136 ? 1.201   25.246 51.175 1.00 29.15 ? 116 PRO   B HD3  1 
ATOM   4034 N  N    A ARG   B 1 137 ? -2.722  28.879 49.877 0.58 21.35 ? 117 ARG   B N    1 
ATOM   4035 N  N    B ARG   B 1 137 ? -2.723  28.877 49.874 0.42 21.42 ? 117 ARG   B N    1 
ATOM   4036 C  CA   A ARG   B 1 137 ? -3.571  29.323 48.779 0.58 24.63 ? 117 ARG   B CA   1 
ATOM   4037 C  CA   B ARG   B 1 137 ? -3.580  29.308 48.777 0.42 24.64 ? 117 ARG   B CA   1 
ATOM   4038 C  C    A ARG   B 1 137 ? -2.691  29.793 47.627 0.58 25.85 ? 117 ARG   B C    1 
ATOM   4039 C  C    B ARG   B 1 137 ? -2.717  29.816 47.629 0.42 25.83 ? 117 ARG   B C    1 
ATOM   4040 O  O    A ARG   B 1 137 ? -1.691  30.487 47.830 0.58 25.55 ? 117 ARG   B O    1 
ATOM   4041 O  O    B ARG   B 1 137 ? -1.754  30.561 47.835 0.42 25.59 ? 117 ARG   B O    1 
ATOM   4042 C  CB   A ARG   B 1 137 ? -4.496  30.451 49.234 0.58 27.92 ? 117 ARG   B CB   1 
ATOM   4043 C  CB   B ARG   B 1 137 ? -4.541  30.398 49.245 0.42 27.98 ? 117 ARG   B CB   1 
ATOM   4044 C  CG   A ARG   B 1 137 ? -5.743  30.614 48.360 0.58 39.13 ? 117 ARG   B CG   1 
ATOM   4045 C  CG   B ARG   B 1 137 ? -5.466  30.915 48.149 0.42 36.22 ? 117 ARG   B CG   1 
ATOM   4046 C  CD   A ARG   B 1 137 ? -6.278  32.048 48.370 0.58 38.83 ? 117 ARG   B CD   1 
ATOM   4047 C  CD   B ARG   B 1 137 ? -6.444  31.960 48.682 0.42 36.81 ? 117 ARG   B CD   1 
ATOM   4048 N  NE   A ARG   B 1 137 ? -7.453  32.203 47.516 0.58 34.36 ? 117 ARG   B NE   1 
ATOM   4049 N  NE   B ARG   B 1 137 ? -7.743  31.396 49.033 0.42 36.53 ? 117 ARG   B NE   1 
ATOM   4050 C  CZ   A ARG   B 1 137 ? -8.695  31.928 47.893 0.58 27.59 ? 117 ARG   B CZ   1 
ATOM   4051 C  CZ   B ARG   B 1 137 ? -8.078  30.964 50.242 0.42 31.56 ? 117 ARG   B CZ   1 
ATOM   4052 N  NH1  A ARG   B 1 137 ? -8.967  31.488 49.111 0.58 37.56 ? 117 ARG   B NH1  1 
ATOM   4053 N  NH1  B ARG   B 1 137 ? -7.217  30.982 51.247 0.42 34.04 ? 117 ARG   B NH1  1 
ATOM   4054 N  NH2  A ARG   B 1 137 ? -9.689  32.090 47.024 0.58 36.13 ? 117 ARG   B NH2  1 
ATOM   4055 N  NH2  B ARG   B 1 137 ? -9.309  30.503 50.448 0.42 36.01 ? 117 ARG   B NH2  1 
ATOM   4056 H  H    A ARG   B 1 137 ? -2.843  29.299 50.618 0.58 25.63 ? 117 ARG   B H    1 
ATOM   4057 H  H    B ARG   B 1 137 ? -2.841  29.303 50.611 0.42 25.73 ? 117 ARG   B H    1 
ATOM   4058 H  HA   A ARG   B 1 137 ? -4.116  28.583 48.470 0.58 29.57 ? 117 ARG   B HA   1 
ATOM   4059 H  HA   B ARG   B 1 137 ? -4.102  28.554 48.459 0.42 29.58 ? 117 ARG   B HA   1 
ATOM   4060 H  HB2  A ARG   B 1 137 ? -4.790  30.268 50.140 0.58 33.52 ? 117 ARG   B HB2  1 
ATOM   4061 H  HB2  B ARG   B 1 137 ? -5.095  30.041 49.956 0.42 33.60 ? 117 ARG   B HB2  1 
ATOM   4062 H  HB3  A ARG   B 1 137 ? -4.005  31.287 49.210 0.58 33.52 ? 117 ARG   B HB3  1 
ATOM   4063 H  HB3  B ARG   B 1 137 ? -4.024  31.149 49.576 0.42 33.60 ? 117 ARG   B HB3  1 
ATOM   4064 H  HG2  A ARG   B 1 137 ? -5.525  30.378 47.445 0.58 46.97 ? 117 ARG   B HG2  1 
ATOM   4065 H  HG2  B ARG   B 1 137 ? -4.937  31.329 47.449 0.42 43.48 ? 117 ARG   B HG2  1 
ATOM   4066 H  HG3  A ARG   B 1 137 ? -6.441  30.033 48.698 0.58 46.97 ? 117 ARG   B HG3  1 
ATOM   4067 H  HG3  B ARG   B 1 137 ? -5.979  30.175 47.788 0.42 43.48 ? 117 ARG   B HG3  1 
ATOM   4068 H  HD2  A ARG   B 1 137 ? -6.522  32.293 49.276 0.58 46.61 ? 117 ARG   B HD2  1 
ATOM   4069 H  HD2  B ARG   B 1 137 ? -6.065  32.379 49.470 0.42 44.19 ? 117 ARG   B HD2  1 
ATOM   4070 H  HD3  A ARG   B 1 137 ? -5.588  32.644 48.040 0.58 46.61 ? 117 ARG   B HD3  1 
ATOM   4071 H  HD3  B ARG   B 1 137 ? -6.589  32.629 47.994 0.42 44.19 ? 117 ARG   B HD3  1 
ATOM   4072 H  HE   A ARG   B 1 137 ? -7.332  32.492 46.715 0.58 41.24 ? 117 ARG   B HE   1 
ATOM   4073 H  HE   B ARG   B 1 137 ? -8.334  31.339 48.411 0.42 43.86 ? 117 ARG   B HE   1 
ATOM   4074 H  HH11 A ARG   B 1 137 ? -8.335  31.376 49.683 0.58 45.09 ? 117 ARG   B HH11 1 
ATOM   4075 H  HH11 B ARG   B 1 137 ? -6.419  31.278 51.130 0.42 40.86 ? 117 ARG   B HH11 1 
ATOM   4076 H  HH12 A ARG   B 1 137 ? -9.780  31.315 49.332 0.58 45.09 ? 117 ARG   B HH12 1 
ATOM   4077 H  HH12 B ARG   B 1 137 ? -7.458  30.696 52.021 0.42 40.86 ? 117 ARG   B HH12 1 
ATOM   4078 H  HH21 A ARG   B 1 137 ? -9.524  32.375 46.230 0.58 43.37 ? 117 ARG   B HH21 1 
ATOM   4079 H  HH21 B ARG   B 1 137 ? -9.876  30.486 49.801 0.42 43.23 ? 117 ARG   B HH21 1 
ATOM   4080 H  HH22 A ARG   B 1 137 ? -10.498 31.915 47.258 0.58 43.37 ? 117 ARG   B HH22 1 
ATOM   4081 H  HH22 B ARG   B 1 137 ? -9.537  30.218 51.227 0.42 43.23 ? 117 ARG   B HH22 1 
ATOM   4082 N  N    . GLY   B 1 138 ? -3.058  29.401 46.409 1.00 22.06 ? 118 GLY   B N    1 
ATOM   4083 C  CA   . GLY   B 1 138 ? -2.270  29.726 45.240 1.00 24.06 ? 118 GLY   B CA   1 
ATOM   4084 C  C    . GLY   B 1 138 ? -3.143  30.199 44.096 1.00 16.07 ? 118 GLY   B C    1 
ATOM   4085 O  O    . GLY   B 1 138 ? -4.369  30.244 44.202 1.00 17.85 ? 118 GLY   B O    1 
ATOM   4086 H  H    A GLY   B 1 138 ? -3.766  28.943 46.239 0.58 26.49 ? 118 GLY   B H    1 
ATOM   4087 H  H    B GLY   B 1 138 ? -3.753  28.924 46.238 0.42 26.49 ? 118 GLY   B H    1 
ATOM   4088 H  HA2  . GLY   B 1 138 ? -1.634  30.427 45.449 1.00 28.89 ? 118 GLY   B HA2  1 
ATOM   4089 H  HA3  . GLY   B 1 138 ? -1.780  28.941 44.950 1.00 28.89 ? 118 GLY   B HA3  1 
ATOM   4090 N  N    . GLN   B 1 139 ? -2.476  30.554 43.001 1.00 16.59 ? 119 GLN   B N    1 
ATOM   4091 C  CA   . GLN   B 1 139 ? -3.132  30.863 41.737 1.00 18.71 ? 119 GLN   B CA   1 
ATOM   4092 C  C    . GLN   B 1 139 ? -2.693  29.810 40.734 1.00 17.44 ? 119 GLN   B C    1 
ATOM   4093 O  O    . GLN   B 1 139 ? -1.495  29.644 40.492 1.00 23.38 ? 119 GLN   B O    1 
ATOM   4094 C  CB   . GLN   B 1 139 ? -2.775  32.266 41.250 1.00 27.32 ? 119 GLN   B CB   1 
ATOM   4095 C  CG   . GLN   B 1 139 ? -3.460  32.652 39.944 1.00 28.84 ? 119 GLN   B CG   1 
ATOM   4096 C  CD   . GLN   B 1 139 ? -4.975  32.769 40.067 1.00 49.01 ? 119 GLN   B CD   1 
ATOM   4097 O  OE1  . GLN   B 1 139 ? -5.519  32.862 41.170 1.00 39.94 ? 119 GLN   B OE1  1 
ATOM   4098 N  NE2  . GLN   B 1 139 ? -5.662  32.764 38.929 1.00 41.46 ? 119 GLN   B NE2  1 
ATOM   4099 H  H    . GLN   B 1 139 ? -1.620  30.624 42.967 1.00 19.92 ? 119 GLN   B H    1 
ATOM   4100 H  HA   . GLN   B 1 139 ? -4.094  30.807 41.844 1.00 22.46 ? 119 GLN   B HA   1 
ATOM   4101 H  HB2  . GLN   B 1 139 ? -3.040  32.909 41.926 1.00 32.80 ? 119 GLN   B HB2  1 
ATOM   4102 H  HB3  . GLN   B 1 139 ? -1.817  32.314 41.108 1.00 32.80 ? 119 GLN   B HB3  1 
ATOM   4103 H  HG2  . GLN   B 1 139 ? -3.119  33.513 39.656 1.00 34.63 ? 119 GLN   B HG2  1 
ATOM   4104 H  HG3  . GLN   B 1 139 ? -3.266  31.981 39.271 1.00 34.63 ? 119 GLN   B HG3  1 
ATOM   4105 H  HE21 . GLN   B 1 139 ? -5.249  32.697 38.178 1.00 49.77 ? 119 GLN   B HE21 1 
ATOM   4106 H  HE22 . GLN   B 1 139 ? -6.520  32.828 38.944 1.00 49.77 ? 119 GLN   B HE22 1 
ATOM   4107 N  N    . TYR   B 1 140 ? -3.655  29.102 40.156 1.00 16.88 ? 120 TYR   B N    1 
ATOM   4108 C  CA   . TYR   B 1 140 ? -3.394  27.982 39.263 1.00 15.58 ? 120 TYR   B CA   1 
ATOM   4109 C  C    . TYR   B 1 140 ? -3.816  28.347 37.850 1.00 14.52 ? 120 TYR   B C    1 
ATOM   4110 O  O    . TYR   B 1 140 ? -4.961  28.746 37.628 1.00 15.90 ? 120 TYR   B O    1 
ATOM   4111 C  CB   . TYR   B 1 140 ? -4.157  26.747 39.761 1.00 14.72 ? 120 TYR   B CB   1 
ATOM   4112 C  CG   . TYR   B 1 140 ? -4.061  25.498 38.920 1.00 12.82 ? 120 TYR   B CG   1 
ATOM   4113 C  CD1  . TYR   B 1 140 ? -2.913  25.194 38.202 1.00 12.08 ? 120 TYR   B CD1  1 
ATOM   4114 C  CD2  . TYR   B 1 140 ? -5.124  24.610 38.858 1.00 12.43 ? 120 TYR   B CD2  1 
ATOM   4115 C  CE1  . TYR   B 1 140 ? -2.834  24.042 37.437 1.00 15.24 ? 120 TYR   B CE1  1 
ATOM   4116 C  CE2  . TYR   B 1 140 ? -5.059  23.464 38.090 1.00 12.97 ? 120 TYR   B CE2  1 
ATOM   4117 C  CZ   . TYR   B 1 140 ? -3.912  23.182 37.384 1.00 13.68 ? 120 TYR   B CZ   1 
ATOM   4118 O  OH   . TYR   B 1 140 ? -3.852  22.035 36.620 1.00 14.87 ? 120 TYR   B OH   1 
ATOM   4119 H  H    . TYR   B 1 140 ? -4.493  29.257 40.270 1.00 20.28 ? 120 TYR   B H    1 
ATOM   4120 H  HA   . TYR   B 1 140 ? -2.446  27.779 39.260 1.00 18.72 ? 120 TYR   B HA   1 
ATOM   4121 H  HB2  . TYR   B 1 140 ? -3.824  26.523 40.644 1.00 17.69 ? 120 TYR   B HB2  1 
ATOM   4122 H  HB3  . TYR   B 1 140 ? -5.097  26.978 39.823 1.00 17.69 ? 120 TYR   B HB3  1 
ATOM   4123 H  HD1  . TYR   B 1 140 ? -2.186  25.773 38.234 1.00 14.51 ? 120 TYR   B HD1  1 
ATOM   4124 H  HD2  . TYR   B 1 140 ? -5.903  24.798 39.331 1.00 14.93 ? 120 TYR   B HD2  1 
ATOM   4125 H  HE1  . TYR   B 1 140 ? -2.061  23.853 36.955 1.00 18.31 ? 120 TYR   B HE1  1 
ATOM   4126 H  HE2  . TYR   B 1 140 ? -5.783  22.882 38.057 1.00 15.58 ? 120 TYR   B HE2  1 
ATOM   4127 H  HH   . TYR   B 1 140 ? -4.574  21.611 36.682 1.00 17.87 ? 120 TYR   B HH   1 
ATOM   4128 N  N    . ARG   B 1 141 ? -2.884  28.227 36.906 1.00 12.85 ? 121 ARG   B N    1 
ATOM   4129 C  CA   . ARG   B 1 141 ? -3.157  28.405 35.486 1.00 13.64 ? 121 ARG   B CA   1 
ATOM   4130 C  C    . ARG   B 1 141 ? -2.636  27.180 34.754 1.00 13.49 ? 121 ARG   B C    1 
ATOM   4131 O  O    . ARG   B 1 141 ? -1.536  26.703 35.052 1.00 16.92 ? 121 ARG   B O    1 
ATOM   4132 C  CB   . ARG   B 1 141 ? -2.478  29.650 34.916 1.00 17.56 ? 121 ARG   B CB   1 
ATOM   4133 C  CG   . ARG   B 1 141 ? -2.911  30.960 35.534 1.00 24.93 ? 121 ARG   B CG   1 
ATOM   4134 C  CD   . ARG   B 1 141 ? -2.080  32.131 35.000 1.00 24.63 ? 121 ARG   B CD   1 
ATOM   4135 N  NE   . ARG   B 1 141 ? -2.182  32.276 33.549 1.00 25.01 ? 121 ARG   B NE   1 
ATOM   4136 C  CZ   . ARG   B 1 141 ? -3.204  32.842 32.919 1.00 30.47 ? 121 ARG   B CZ   1 
ATOM   4137 N  NH1  . ARG   B 1 141 ? -4.236  33.339 33.582 1.00 31.70 ? 121 ARG   B NH1  1 
ATOM   4138 N  NH2  . ARG   B 1 141 ? -3.195  32.902 31.590 1.00 32.73 ? 121 ARG   B NH2  1 
ATOM   4139 H  H    . ARG   B 1 141 ? -2.062  28.037 37.072 1.00 15.44 ? 121 ARG   B H    1 
ATOM   4140 H  HA   . ARG   B 1 141 ? -4.113  28.474 35.339 1.00 16.38 ? 121 ARG   B HA   1 
ATOM   4141 H  HB2  . ARG   B 1 141 ? -1.521  29.567 35.049 1.00 21.09 ? 121 ARG   B HB2  1 
ATOM   4142 H  HB3  . ARG   B 1 141 ? -2.670  29.697 33.966 1.00 21.09 ? 121 ARG   B HB3  1 
ATOM   4143 H  HG2  . ARG   B 1 141 ? -3.842  31.124 35.318 1.00 29.93 ? 121 ARG   B HG2  1 
ATOM   4144 H  HG3  . ARG   B 1 141 ? -2.792  30.916 36.496 1.00 29.93 ? 121 ARG   B HG3  1 
ATOM   4145 H  HD2  . ARG   B 1 141 ? -2.391  32.954 35.409 1.00 29.57 ? 121 ARG   B HD2  1 
ATOM   4146 H  HD3  . ARG   B 1 141 ? -1.147  31.983 35.221 1.00 29.57 ? 121 ARG   B HD3  1 
ATOM   4147 H  HE   . ARG   B 1 141 ? -1.535  31.974 33.070 1.00 30.03 ? 121 ARG   B HE   1 
ATOM   4148 H  HH11 . ARG   B 1 141 ? -4.256  33.305 34.441 1.00 38.06 ? 121 ARG   B HH11 1 
ATOM   4149 H  HH12 . ARG   B 1 141 ? -4.888  33.700 33.152 1.00 38.06 ? 121 ARG   B HH12 1 
ATOM   4150 H  HH21 . ARG   B 1 141 ? -2.530  32.581 31.150 1.00 39.30 ? 121 ARG   B HH21 1 
ATOM   4151 H  HH22 . ARG   B 1 141 ? -3.852  33.266 31.172 1.00 39.30 ? 121 ARG   B HH22 1 
ATOM   4152 N  N    . ASN   B 1 142 ? -3.401  26.678 33.787 1.00 13.37 ? 122 ASN   B N    1 
ATOM   4153 C  CA   . ASN   B 1 142 ? -2.909  25.546 33.014 1.00 12.81 ? 122 ASN   B CA   1 
ATOM   4154 C  C    . ASN   B 1 142 ? -3.609  25.472 31.668 1.00 14.79 ? 122 ASN   B C    1 
ATOM   4155 O  O    . ASN   B 1 142 ? -4.647  26.094 31.438 1.00 13.25 ? 122 ASN   B O    1 
ATOM   4156 C  CB   . ASN   B 1 142 ? -3.087  24.239 33.795 1.00 15.81 ? 122 ASN   B CB   1 
ATOM   4157 C  CG   . ASN   B 1 142 ? -1.953  23.259 33.569 1.00 14.52 ? 122 ASN   B CG   1 
ATOM   4158 O  OD1  . ASN   B 1 142 ? -1.118  23.447 32.683 1.00 14.57 ? 122 ASN   B OD1  1 
ATOM   4159 N  ND2  . ASN   B 1 142 ? -1.919  22.204 34.380 1.00 12.86 ? 122 ASN   B ND2  1 
ATOM   4160 H  H    . ASN   B 1 142 ? -4.181  26.964 33.566 1.00 16.06 ? 122 ASN   B H    1 
ATOM   4161 H  HA   . ASN   B 1 142 ? -1.962  25.671 32.849 1.00 15.38 ? 122 ASN   B HA   1 
ATOM   4162 H  HB2  . ASN   B 1 142 ? -3.130  24.439 34.742 1.00 18.99 ? 122 ASN   B HB2  1 
ATOM   4163 H  HB3  . ASN   B 1 142 ? -3.905  23.809 33.509 1.00 18.99 ? 122 ASN   B HB3  1 
ATOM   4164 H  HD21 . ASN   B 1 142 ? -1.296  21.617 34.296 1.00 15.45 ? 122 ASN   B HD21 1 
ATOM   4165 H  HD22 . ASN   B 1 142 ? -2.520  22.109 34.987 1.00 15.45 ? 122 ASN   B HD22 1 
ATOM   4166 N  N    . HIS   B 1 143 ? -2.985  24.725 30.770 1.00 13.08 ? 123 HIS   B N    1 
ATOM   4167 C  CA   . HIS   B 1 143 ? -3.554  24.368 29.484 1.00 13.37 ? 123 HIS   B CA   1 
ATOM   4168 C  C    . HIS   B 1 143 ? -4.226  23.014 29.616 1.00 12.98 ? 123 HIS   B C    1 
ATOM   4169 O  O    . HIS   B 1 143 ? -3.708  22.119 30.291 1.00 16.21 ? 123 HIS   B O    1 
ATOM   4170 C  CB   . HIS   B 1 143 ? -2.440  24.333 28.449 1.00 12.79 ? 123 HIS   B CB   1 
ATOM   4171 C  CG   . HIS   B 1 143 ? -2.872  23.883 27.097 1.00 12.58 ? 123 HIS   B CG   1 
ATOM   4172 N  ND1  . HIS   B 1 143 ? -2.875  22.557 26.725 1.00 16.31 ? 123 HIS   B ND1  1 
ATOM   4173 C  CD2  . HIS   B 1 143 ? -3.291  24.582 26.018 1.00 16.73 ? 123 HIS   B CD2  1 
ATOM   4174 C  CE1  . HIS   B 1 143 ? -3.288  22.458 25.476 1.00 19.37 ? 123 HIS   B CE1  1 
ATOM   4175 N  NE2  . HIS   B 1 143 ? -3.539  23.673 25.021 1.00 15.90 ? 123 HIS   B NE2  1 
ATOM   4176 H  H    . HIS   B 1 143 ? -2.198  24.401 30.891 1.00 15.72 ? 123 HIS   B H    1 
ATOM   4177 H  HA   . HIS   B 1 143 ? -4.215  25.026 29.217 1.00 16.06 ? 123 HIS   B HA   1 
ATOM   4178 H  HB2  . HIS   B 1 143 ? -2.072  25.226 28.359 1.00 15.37 ? 123 HIS   B HB2  1 
ATOM   4179 H  HB3  . HIS   B 1 143 ? -1.750  23.724 28.756 1.00 15.37 ? 123 HIS   B HB3  1 
ATOM   4180 H  HD2  . HIS   B 1 143 ? -3.387  25.505 25.961 1.00 20.09 ? 123 HIS   B HD2  1 
ATOM   4181 H  HE1  . HIS   B 1 143 ? -3.380  21.667 24.995 1.00 23.26 ? 123 HIS   B HE1  1 
ATOM   4182 H  HE2  . HIS   B 1 143 ? -3.826  23.862 24.233 1.00 19.10 ? 123 HIS   B HE2  1 
ATOM   4183 N  N    . PHE   B 1 144 ? -5.390  22.874 28.983 1.00 12.51 ? 124 PHE   B N    1 
ATOM   4184 C  CA   . PHE   B 1 144 ? -6.187  21.671 29.123 1.00 10.31 ? 124 PHE   B CA   1 
ATOM   4185 C  C    . PHE   B 1 144 ? -6.670  21.148 27.779 1.00 12.81 ? 124 PHE   B C    1 
ATOM   4186 O  O    . PHE   B 1 144 ? -6.971  21.911 26.853 1.00 14.20 ? 124 PHE   B O    1 
ATOM   4187 C  CB   . PHE   B 1 144 ? -7.445  21.901 30.005 1.00 13.07 ? 124 PHE   B CB   1 
ATOM   4188 C  CG   . PHE   B 1 144 ? -7.137  22.177 31.440 1.00 12.17 ? 124 PHE   B CG   1 
ATOM   4189 C  CD1  . PHE   B 1 144 ? -6.794  23.450 31.863 1.00 10.73 ? 124 PHE   B CD1  1 
ATOM   4190 C  CD2  . PHE   B 1 144 ? -7.201  21.160 32.370 1.00 14.14 ? 124 PHE   B CD2  1 
ATOM   4191 C  CE1  . PHE   B 1 144 ? -6.506  23.690 33.192 1.00 15.63 ? 124 PHE   B CE1  1 
ATOM   4192 C  CE2  . PHE   B 1 144 ? -6.915  21.393 33.694 1.00 15.79 ? 124 PHE   B CE2  1 
ATOM   4193 C  CZ   . PHE   B 1 144 ? -6.560  22.658 34.109 1.00 13.54 ? 124 PHE   B CZ   1 
ATOM   4194 H  H    . PHE   B 1 144 ? -5.737  23.467 28.466 1.00 15.03 ? 124 PHE   B H    1 
ATOM   4195 H  HA   . PHE   B 1 144 ? -5.652  20.978 29.539 1.00 12.39 ? 124 PHE   B HA   1 
ATOM   4196 H  HB2  . PHE   B 1 144 ? -7.936  22.661 29.656 1.00 15.70 ? 124 PHE   B HB2  1 
ATOM   4197 H  HB3  . PHE   B 1 144 ? -8.001  21.107 29.969 1.00 15.70 ? 124 PHE   B HB3  1 
ATOM   4198 H  HD1  . PHE   B 1 144 ? -6.747  24.145 31.247 1.00 12.89 ? 124 PHE   B HD1  1 
ATOM   4199 H  HD2  . PHE   B 1 144 ? -7.430  20.302 32.095 1.00 16.99 ? 124 PHE   B HD2  1 
ATOM   4200 H  HE1  . PHE   B 1 144 ? -6.271  24.546 33.469 1.00 18.77 ? 124 PHE   B HE1  1 
ATOM   4201 H  HE2  . PHE   B 1 144 ? -6.957  20.696 34.309 1.00 18.97 ? 124 PHE   B HE2  1 
ATOM   4202 H  HZ   . PHE   B 1 144 ? -6.374  22.820 35.006 1.00 16.27 ? 124 PHE   B HZ   1 
ATOM   4203 N  N    . LEU   B 1 145 ? -6.788  19.827 27.708 1.00 10.63 ? 125 LEU   B N    1 
ATOM   4204 C  CA   . LEU   B 1 145 ? -7.557  19.146 26.678 1.00 10.42 ? 125 LEU   B CA   1 
ATOM   4205 C  C    . LEU   B 1 145 ? -8.673  18.368 27.365 1.00 10.64 ? 125 LEU   B C    1 
ATOM   4206 O  O    . LEU   B 1 145 ? -8.426  17.679 28.361 1.00 14.27 ? 125 LEU   B O    1 
ATOM   4207 C  CB   . LEU   B 1 145 ? -6.662  18.213 25.859 1.00 12.13 ? 125 LEU   B CB   1 
ATOM   4208 C  CG   . LEU   B 1 145 ? -5.480  18.910 25.187 1.00 16.46 ? 125 LEU   B CG   1 
ATOM   4209 C  CD1  . LEU   B 1 145 ? -4.481  17.920 24.624 1.00 21.50 ? 125 LEU   B CD1  1 
ATOM   4210 C  CD2  . LEU   B 1 145 ? -5.974  19.821 24.091 1.00 17.81 ? 125 LEU   B CD2  1 
ATOM   4211 H  H    . LEU   B 1 145 ? -6.418  19.287 28.266 1.00 12.78 ? 125 LEU   B H    1 
ATOM   4212 H  HA   . LEU   B 1 145 ? -7.955  19.798 26.082 1.00 12.52 ? 125 LEU   B HA   1 
ATOM   4213 H  HB2  . LEU   B 1 145 ? -6.306  17.528 26.447 1.00 14.58 ? 125 LEU   B HB2  1 
ATOM   4214 H  HB3  . LEU   B 1 145 ? -7.197  17.801 25.163 1.00 14.58 ? 125 LEU   B HB3  1 
ATOM   4215 H  HG   . LEU   B 1 145 ? -5.020  19.456 25.844 1.00 19.76 ? 125 LEU   B HG   1 
ATOM   4216 H  HD11 . LEU   B 1 145 ? -3.799  18.405 24.134 1.00 25.82 ? 125 LEU   B HD11 1 
ATOM   4217 H  HD12 . LEU   B 1 145 ? -4.076  17.430 25.356 1.00 25.82 ? 125 LEU   B HD12 1 
ATOM   4218 H  HD13 . LEU   B 1 145 ? -4.943  17.309 24.029 1.00 25.82 ? 125 LEU   B HD13 1 
ATOM   4219 H  HD21 . LEU   B 1 145 ? -5.211  20.190 23.620 1.00 21.39 ? 125 LEU   B HD21 1 
ATOM   4220 H  HD22 . LEU   B 1 145 ? -6.524  19.308 23.479 1.00 21.39 ? 125 LEU   B HD22 1 
ATOM   4221 H  HD23 . LEU   B 1 145 ? -6.496  20.536 24.486 1.00 21.39 ? 125 LEU   B HD23 1 
ATOM   4222 N  N    . HIS   B 1 146 ? -9.895  18.477 26.828 1.00 10.69 ? 126 HIS   B N    1 
ATOM   4223 C  CA   . HIS   B 1 146 ? -11.037 17.725 27.320 1.00 9.89  ? 126 HIS   B CA   1 
ATOM   4224 C  C    . HIS   B 1 146 ? -11.565 16.806 26.225 1.00 12.34 ? 126 HIS   B C    1 
ATOM   4225 O  O    . HIS   B 1 146 ? -11.645 17.193 25.051 1.00 13.78 ? 126 HIS   B O    1 
ATOM   4226 C  CB   . HIS   B 1 146 ? -12.210 18.606 27.767 1.00 10.87 ? 126 HIS   B CB   1 
ATOM   4227 C  CG   . HIS   B 1 146 ? -11.943 19.450 28.972 1.00 14.12 ? 126 HIS   B CG   1 
ATOM   4228 N  ND1  . HIS   B 1 146 ? -12.438 19.142 30.223 1.00 19.07 ? 126 HIS   B ND1  1 
ATOM   4229 C  CD2  . HIS   B 1 146 ? -11.291 20.629 29.105 1.00 14.93 ? 126 HIS   B CD2  1 
ATOM   4230 C  CE1  . HIS   B 1 146 ? -12.071 20.079 31.080 1.00 20.07 ? 126 HIS   B CE1  1 
ATOM   4231 N  NE2  . HIS   B 1 146 ? -11.375 20.992 30.427 1.00 15.97 ? 126 HIS   B NE2  1 
ATOM   4232 H  H    . HIS   B 1 146 ? -10.083 18.992 26.165 1.00 12.84 ? 126 HIS   B H    1 
ATOM   4233 H  HA   . HIS   B 1 146 ? -10.763 17.179 28.072 1.00 11.89 ? 126 HIS   B HA   1 
ATOM   4234 H  HB2  . HIS   B 1 146 ? -12.446 19.200 27.039 1.00 13.06 ? 126 HIS   B HB2  1 
ATOM   4235 H  HB3  . HIS   B 1 146 ? -12.964 18.032 27.974 1.00 13.06 ? 126 HIS   B HB3  1 
ATOM   4236 H  HD2  . HIS   B 1 146 ? -10.853 21.097 28.431 1.00 17.93 ? 126 HIS   B HD2  1 
ATOM   4237 H  HE1  . HIS   B 1 146 ? -12.270 20.093 31.988 1.00 24.10 ? 126 HIS   B HE1  1 
ATOM   4238 H  HE2  . HIS   B 1 146 ? -11.029 21.699 30.773 1.00 19.18 ? 126 HIS   B HE2  1 
ATOM   4239 N  N    . SER   B 1 147 ? -11.948 15.601 26.630 1.00 9.99  ? 127 SER   B N    1 
ATOM   4240 C  CA   . SER   B 1 147 ? -12.641 14.625 25.800 1.00 7.98  ? 127 SER   B CA   1 
ATOM   4241 C  C    . SER   B 1 147 ? -14.073 14.497 26.308 1.00 9.99  ? 127 SER   B C    1 
ATOM   4242 O  O    . SER   B 1 147 ? -14.281 14.317 27.508 1.00 11.74 ? 127 SER   B O    1 
ATOM   4243 C  CB   . SER   B 1 147 ? -11.938 13.268 25.890 1.00 11.45 ? 127 SER   B CB   1 
ATOM   4244 O  OG   . SER   B 1 147 ? -12.608 12.268 25.139 1.00 12.75 ? 127 SER   B OG   1 
ATOM   4245 H  H    . SER   B 1 147 ? -11.808 15.312 27.428 1.00 12.01 ? 127 SER   B H    1 
ATOM   4246 H  HA   . SER   B 1 147 ? -12.654 14.918 24.875 1.00 9.60  ? 127 SER   B HA   1 
ATOM   4247 H  HB2  . SER   B 1 147 ? -11.035 13.359 25.556 1.00 13.76 ? 127 SER   B HB2  1 
ATOM   4248 H  HB3  . SER   B 1 147 ? -11.915 12.993 26.820 1.00 13.76 ? 127 SER   B HB3  1 
ATOM   4249 H  HG   . SER   B 1 147 ? -13.378 12.142 25.450 1.00 15.32 ? 127 SER   B HG   1 
ATOM   4250 N  N    . PHE   B 1 148 ? -15.052 14.583 25.400 1.00 11.82 ? 128 PHE   B N    1 
ATOM   4251 C  CA   . PHE   B 1 148 ? -16.463 14.414 25.748 1.00 9.65  ? 128 PHE   B CA   1 
ATOM   4252 C  C    . PHE   B 1 148 ? -17.053 13.333 24.849 1.00 12.96 ? 128 PHE   B C    1 
ATOM   4253 O  O    . PHE   B 1 148 ? -17.103 13.508 23.625 1.00 15.05 ? 128 PHE   B O    1 
ATOM   4254 C  CB   . PHE   B 1 148 ? -17.287 15.708 25.563 1.00 12.25 ? 128 PHE   B CB   1 
ATOM   4255 C  CG   . PHE   B 1 148 ? -16.948 16.815 26.522 1.00 12.55 ? 128 PHE   B CG   1 
ATOM   4256 C  CD1  . PHE   B 1 148 ? -15.932 17.712 26.241 1.00 13.52 ? 128 PHE   B CD1  1 
ATOM   4257 C  CD2  . PHE   B 1 148 ? -17.668 16.983 27.695 1.00 12.46 ? 128 PHE   B CD2  1 
ATOM   4258 C  CE1  . PHE   B 1 148 ? -15.626 18.742 27.125 1.00 14.03 ? 128 PHE   B CE1  1 
ATOM   4259 C  CE2  . PHE   B 1 148 ? -17.363 18.003 28.578 1.00 13.95 ? 128 PHE   B CE2  1 
ATOM   4260 C  CZ   . PHE   B 1 148 ? -16.344 18.889 28.290 1.00 14.03 ? 128 PHE   B CZ   1 
ATOM   4261 H  H    . PHE   B 1 148 ? -14.920 14.741 24.565 1.00 14.20 ? 128 PHE   B H    1 
ATOM   4262 H  HA   . PHE   B 1 148 ? -16.542 14.126 26.671 1.00 11.59 ? 128 PHE   B HA   1 
ATOM   4263 H  HB2  . PHE   B 1 148 ? -17.139 16.043 24.665 1.00 14.72 ? 128 PHE   B HB2  1 
ATOM   4264 H  HB3  . PHE   B 1 148 ? -18.226 15.496 25.681 1.00 14.72 ? 128 PHE   B HB3  1 
ATOM   4265 H  HD1  . PHE   B 1 148 ? -15.442 17.619 25.456 1.00 16.24 ? 128 PHE   B HD1  1 
ATOM   4266 H  HD2  . PHE   B 1 148 ? -18.356 16.391 27.899 1.00 14.97 ? 128 PHE   B HD2  1 
ATOM   4267 H  HE1  . PHE   B 1 148 ? -14.937 19.334 26.927 1.00 16.85 ? 128 PHE   B HE1  1 
ATOM   4268 H  HE2  . PHE   B 1 148 ? -17.853 18.099 29.363 1.00 16.76 ? 128 PHE   B HE2  1 
ATOM   4269 H  HZ   . PHE   B 1 148 ? -16.140 19.576 28.882 1.00 16.86 ? 128 PHE   B HZ   1 
ATOM   4270 N  N    . ARG   B 1 149 ? -17.536 12.244 25.443 1.00 15.05 ? 129 ARG   B N    1 
ATOM   4271 C  CA   . ARG   B 1 149 ? -18.275 11.218 24.719 1.00 13.93 ? 129 ARG   B CA   1 
ATOM   4272 C  C    . ARG   B 1 149 ? -19.713 11.191 25.221 1.00 15.34 ? 129 ARG   B C    1 
ATOM   4273 O  O    . ARG   B 1 149 ? -19.960 11.270 26.430 1.00 16.23 ? 129 ARG   B O    1 
ATOM   4274 C  CB   . ARG   B 1 149 ? -17.609 9.853  24.878 1.00 16.11 ? 129 ARG   B CB   1 
ATOM   4275 C  CG   . ARG   B 1 149 ? -16.181 9.813  24.331 1.00 14.91 ? 129 ARG   B CG   1 
ATOM   4276 C  CD   . ARG   B 1 149 ? -15.623 8.406  24.354 1.00 15.13 ? 129 ARG   B CD   1 
ATOM   4277 N  NE   . ARG   B 1 149 ? -16.264 7.578  23.338 1.00 20.20 ? 129 ARG   B NE   1 
ATOM   4278 C  CZ   . ARG   B 1 149 ? -15.977 6.304  23.113 1.00 26.92 ? 129 ARG   B CZ   1 
ATOM   4279 N  NH1  . ARG   B 1 149 ? -15.109 5.649  23.864 1.00 26.58 ? 129 ARG   B NH1  1 
ATOM   4280 N  NH2  . ARG   B 1 149 ? -16.571 5.674  22.102 1.00 25.82 ? 129 ARG   B NH2  1 
ATOM   4281 H  H    . ARG   B 1 149 ? -17.446 12.075 26.281 1.00 18.07 ? 129 ARG   B H    1 
ATOM   4282 H  HA   . ARG   B 1 149 ? -18.285 11.439 23.777 1.00 16.74 ? 129 ARG   B HA   1 
ATOM   4283 H  HB2  . ARG   B 1 149 ? -17.574 9.628  25.821 1.00 19.35 ? 129 ARG   B HB2  1 
ATOM   4284 H  HB3  . ARG   B 1 149 ? -18.131 9.191  24.399 1.00 19.35 ? 129 ARG   B HB3  1 
ATOM   4285 H  HG2  . ARG   B 1 149 ? -16.180 10.126 23.413 1.00 17.91 ? 129 ARG   B HG2  1 
ATOM   4286 H  HG3  . ARG   B 1 149 ? -15.612 10.376 24.879 1.00 17.91 ? 129 ARG   B HG3  1 
ATOM   4287 H  HD2  . ARG   B 1 149 ? -14.671 8.433  24.171 1.00 18.17 ? 129 ARG   B HD2  1 
ATOM   4288 H  HD3  . ARG   B 1 149 ? -15.789 8.008  25.223 1.00 18.17 ? 129 ARG   B HD3  1 
ATOM   4289 H  HE   . ARG   B 1 149 ? -16.871 7.943  22.850 1.00 24.26 ? 129 ARG   B HE   1 
ATOM   4290 H  HH11 . ARG   B 1 149 ? -14.716 6.047  24.517 1.00 31.91 ? 129 ARG   B HH11 1 
ATOM   4291 H  HH12 . ARG   B 1 149 ? -14.938 4.822  23.700 1.00 31.91 ? 129 ARG   B HH12 1 
ATOM   4292 H  HH21 . ARG   B 1 149 ? -17.138 6.092  21.609 1.00 31.01 ? 129 ARG   B HH21 1 
ATOM   4293 H  HH22 . ARG   B 1 149 ? -16.396 4.846  21.949 1.00 31.01 ? 129 ARG   B HH22 1 
ATOM   4294 N  N    . PHE   B 1 150 ? -20.653 11.085 24.280 1.00 15.25 ? 130 PHE   B N    1 
ATOM   4295 C  CA   . PHE   B 1 150 ? -22.073 11.249 24.541 1.00 14.39 ? 130 PHE   B CA   1 
ATOM   4296 C  C    . PHE   B 1 150 ? -22.844 9.950  24.349 1.00 15.88 ? 130 PHE   B C    1 
ATOM   4297 O  O    . PHE   B 1 150 ? -22.453 9.077  23.565 1.00 17.42 ? 130 PHE   B O    1 
ATOM   4298 C  CB   . PHE   B 1 150 ? -22.675 12.330 23.614 1.00 11.04 ? 130 PHE   B CB   1 
ATOM   4299 C  CG   . PHE   B 1 150 ? -22.317 13.731 24.016 1.00 16.79 ? 130 PHE   B CG   1 
ATOM   4300 C  CD1  . PHE   B 1 150 ? -21.117 14.302 23.617 1.00 17.96 ? 130 PHE   B CD1  1 
ATOM   4301 C  CD2  . PHE   B 1 150 ? -23.170 14.473 24.806 1.00 17.08 ? 130 PHE   B CD2  1 
ATOM   4302 C  CE1  . PHE   B 1 150 ? -20.782 15.585 24.013 1.00 14.39 ? 130 PHE   B CE1  1 
ATOM   4303 C  CE2  . PHE   B 1 150 ? -22.839 15.755 25.199 1.00 18.94 ? 130 PHE   B CE2  1 
ATOM   4304 C  CZ   . PHE   B 1 150 ? -21.641 16.308 24.806 1.00 18.52 ? 130 PHE   B CZ   1 
ATOM   4305 H  H    . PHE   B 1 150 ? -20.480 10.912 23.456 1.00 18.32 ? 130 PHE   B H    1 
ATOM   4306 H  HA   . PHE   B 1 150 ? -22.195 11.538 25.458 1.00 17.28 ? 130 PHE   B HA   1 
ATOM   4307 H  HB2  . PHE   B 1 150 ? -22.348 12.187 22.712 1.00 13.26 ? 130 PHE   B HB2  1 
ATOM   4308 H  HB3  . PHE   B 1 150 ? -23.642 12.254 23.630 1.00 13.26 ? 130 PHE   B HB3  1 
ATOM   4309 H  HD1  . PHE   B 1 150 ? -20.527 13.813 23.090 1.00 21.57 ? 130 PHE   B HD1  1 
ATOM   4310 H  HD2  . PHE   B 1 150 ? -23.976 14.102 25.085 1.00 20.51 ? 130 PHE   B HD2  1 
ATOM   4311 H  HE1  . PHE   B 1 150 ? -19.976 15.959 23.740 1.00 17.29 ? 130 PHE   B HE1  1 
ATOM   4312 H  HE2  . PHE   B 1 150 ? -23.424 16.243 25.732 1.00 22.74 ? 130 PHE   B HE2  1 
ATOM   4313 H  HZ   . PHE   B 1 150 ? -21.422 17.175 25.061 1.00 22.25 ? 130 PHE   B HZ   1 
ATOM   4314 N  N    . GLU   B 1 151 ? -23.963 9.859  25.064 1.00 15.91 ? 131 GLU   B N    1 
ATOM   4315 C  CA   . GLU   B 1 151 ? -24.922 8.770  24.910 1.00 21.96 ? 131 GLU   B CA   1 
ATOM   4316 C  C    . GLU   B 1 151 ? -26.305 9.367  25.114 1.00 20.55 ? 131 GLU   B C    1 
ATOM   4317 O  O    . GLU   B 1 151 ? -26.591 9.913  26.185 1.00 19.53 ? 131 GLU   B O    1 
ATOM   4318 C  CB   . GLU   B 1 151 ? -24.650 7.657  25.908 1.00 27.04 ? 131 GLU   B CB   1 
ATOM   4319 C  CG   . GLU   B 1 151 ? -25.656 6.523  25.894 1.00 33.97 ? 131 GLU   B CG   1 
ATOM   4320 C  CD   . GLU   B 1 151 ? -25.315 5.470  26.929 1.00 45.20 ? 131 GLU   B CD   1 
ATOM   4321 O  OE1  . GLU   B 1 151 ? -24.329 4.733  26.719 1.00 42.79 ? 131 GLU   B OE1  1 
ATOM   4322 O  OE2  . GLU   B 1 151 ? -26.007 5.404  27.967 1.00 46.44 ? 131 GLU   B OE2  1 
ATOM   4323 H  H    . GLU   B 1 151 ? -24.194 10.433 25.661 1.00 19.11 ? 131 GLU   B H    1 
ATOM   4324 H  HA   . GLU   B 1 151 ? -24.867 8.407  24.012 1.00 26.37 ? 131 GLU   B HA   1 
ATOM   4325 H  HB2  . GLU   B 1 151 ? -23.778 7.277  25.716 1.00 32.47 ? 131 GLU   B HB2  1 
ATOM   4326 H  HB3  . GLU   B 1 151 ? -24.650 8.037  26.801 1.00 32.47 ? 131 GLU   B HB3  1 
ATOM   4327 H  HG2  . GLU   B 1 151 ? -26.538 6.870  26.097 1.00 40.79 ? 131 GLU   B HG2  1 
ATOM   4328 H  HG3  . GLU   B 1 151 ? -25.653 6.103  25.020 1.00 40.79 ? 131 GLU   B HG3  1 
ATOM   4329 N  N    . ASN   B 1 152 ? -27.134 9.303  24.075 1.00 24.71 ? 132 ASN   B N    1 
ATOM   4330 C  CA   . ASN   B 1 152 ? -28.531 9.729  24.143 1.00 30.43 ? 132 ASN   B CA   1 
ATOM   4331 C  C    . ASN   B 1 152 ? -28.659 11.142 24.708 1.00 23.79 ? 132 ASN   B C    1 
ATOM   4332 O  O    . ASN   B 1 152 ? -29.463 11.416 25.602 1.00 26.73 ? 132 ASN   B O    1 
ATOM   4333 C  CB   . ASN   B 1 152 ? -29.361 8.736  24.961 1.00 28.14 ? 132 ASN   B CB   1 
ATOM   4334 C  CG   . ASN   B 1 152 ? -30.850 9.038  24.915 1.00 48.16 ? 132 ASN   B CG   1 
ATOM   4335 O  OD1  . ASN   B 1 152 ? -31.335 9.686  23.985 1.00 41.73 ? 132 ASN   B OD1  1 
ATOM   4336 N  ND2  . ASN   B 1 152 ? -31.585 8.566  25.923 1.00 36.41 ? 132 ASN   B ND2  1 
ATOM   4337 H  H    . ASN   B 1 152 ? -26.905 9.009  23.300 1.00 29.67 ? 132 ASN   B H    1 
ATOM   4338 H  HA   . ASN   B 1 152 ? -28.893 9.741  23.243 1.00 36.53 ? 132 ASN   B HA   1 
ATOM   4339 H  HB2  . ASN   B 1 152 ? -29.225 7.843  24.607 1.00 33.79 ? 132 ASN   B HB2  1 
ATOM   4340 H  HB3  . ASN   B 1 152 ? -29.076 8.773  25.887 1.00 33.79 ? 132 ASN   B HB3  1 
ATOM   4341 H  HD21 . ASN   B 1 152 ? -32.433 8.711  25.942 1.00 43.71 ? 132 ASN   B HD21 1 
ATOM   4342 H  HD22 . ASN   B 1 152 ? -31.211 8.118  26.555 1.00 43.71 ? 132 ASN   B HD22 1 
ATOM   4343 N  N    . GLY   B 1 153 ? -27.851 12.053 24.173 1.00 25.15 ? 133 GLY   B N    1 
ATOM   4344 C  CA   . GLY   B 1 153 ? -28.027 13.461 24.430 1.00 25.15 ? 133 GLY   B CA   1 
ATOM   4345 C  C    . GLY   B 1 153 ? -27.275 14.006 25.620 1.00 16.67 ? 133 GLY   B C    1 
ATOM   4346 O  O    . GLY   B 1 153 ? -27.302 15.227 25.837 1.00 17.88 ? 133 GLY   B O    1 
ATOM   4347 H  H    . GLY   B 1 153 ? -27.190 11.871 23.654 1.00 30.20 ? 133 GLY   B H    1 
ATOM   4348 H  HA2  . GLY   B 1 153 ? -27.743 13.958 23.647 1.00 30.19 ? 133 GLY   B HA2  1 
ATOM   4349 H  HA3  . GLY   B 1 153 ? -28.971 13.638 24.569 1.00 30.19 ? 133 GLY   B HA3  1 
ATOM   4350 N  N    . LEU   B 1 154 ? -26.596 13.156 26.391 1.00 18.00 ? 134 LEU   B N    1 
ATOM   4351 C  CA   . LEU   B 1 154 ? -25.882 13.594 27.579 1.00 14.31 ? 134 LEU   B CA   1 
ATOM   4352 C  C    . LEU   B 1 154 ? -24.480 13.004 27.615 1.00 13.80 ? 134 LEU   B C    1 
ATOM   4353 O  O    . LEU   B 1 154 ? -24.142 12.072 26.879 1.00 15.27 ? 134 LEU   B O    1 
ATOM   4354 C  CB   . LEU   B 1 154 ? -26.642 13.209 28.853 1.00 14.85 ? 134 LEU   B CB   1 
ATOM   4355 C  CG   . LEU   B 1 154 ? -27.999 13.886 29.015 1.00 18.79 ? 134 LEU   B CG   1 
ATOM   4356 C  CD1  . LEU   B 1 154 ? -28.751 13.253 30.156 1.00 19.80 ? 134 LEU   B CD1  1 
ATOM   4357 C  CD2  . LEU   B 1 154 ? -27.829 15.370 29.248 1.00 20.40 ? 134 LEU   B CD2  1 
ATOM   4358 H  H    . LEU   B 1 154 ? -26.536 12.311 26.242 1.00 21.62 ? 134 LEU   B H    1 
ATOM   4359 H  HA   . LEU   B 1 154 ? -25.795 14.559 27.561 1.00 17.19 ? 134 LEU   B HA   1 
ATOM   4360 H  HB2  . LEU   B 1 154 ? -26.791 12.251 28.846 1.00 17.83 ? 134 LEU   B HB2  1 
ATOM   4361 H  HB3  . LEU   B 1 154 ? -26.101 13.449 29.621 1.00 17.83 ? 134 LEU   B HB3  1 
ATOM   4362 H  HG   . LEU   B 1 154 ? -28.517 13.763 28.204 1.00 22.56 ? 134 LEU   B HG   1 
ATOM   4363 H  HD11 . LEU   B 1 154 ? -29.610 13.694 30.251 1.00 23.78 ? 134 LEU   B HD11 1 
ATOM   4364 H  HD12 . LEU   B 1 154 ? -28.882 12.311 29.964 1.00 23.78 ? 134 LEU   B HD12 1 
ATOM   4365 H  HD13 . LEU   B 1 154 ? -28.234 13.356 30.970 1.00 23.78 ? 134 LEU   B HD13 1 
ATOM   4366 H  HD21 . LEU   B 1 154 ? -28.692 15.755 29.468 1.00 24.50 ? 134 LEU   B HD21 1 
ATOM   4367 H  HD22 . LEU   B 1 154 ? -27.210 15.505 29.982 1.00 24.50 ? 134 LEU   B HD22 1 
ATOM   4368 H  HD23 . LEU   B 1 154 ? -27.480 15.780 28.441 1.00 24.50 ? 134 LEU   B HD23 1 
ATOM   4369 N  N    . ILE   B 1 155 ? -23.660 13.555 28.504 1.00 13.19 ? 135 ILE   B N    1 
ATOM   4370 C  CA   . ILE   B 1 155 ? -22.260 13.164 28.593 1.00 14.23 ? 135 ILE   B CA   1 
ATOM   4371 C  C    . ILE   B 1 155 ? -22.160 11.814 29.294 1.00 16.38 ? 135 ILE   B C    1 
ATOM   4372 O  O    . ILE   B 1 155 ? -22.580 11.666 30.443 1.00 15.53 ? 135 ILE   B O    1 
ATOM   4373 C  CB   . ILE   B 1 155 ? -21.430 14.222 29.332 1.00 14.09 ? 135 ILE   B CB   1 
ATOM   4374 C  CG1  . ILE   B 1 155 ? -21.479 15.567 28.608 1.00 12.63 ? 135 ILE   B CG1  1 
ATOM   4375 C  CG2  . ILE   B 1 155 ? -19.985 13.739 29.455 1.00 16.18 ? 135 ILE   B CG2  1 
ATOM   4376 C  CD1  . ILE   B 1 155 ? -20.984 16.730 29.478 1.00 14.49 ? 135 ILE   B CD1  1 
ATOM   4377 H  H    . ILE   B 1 155 ? -23.892 14.160 29.069 1.00 15.85 ? 135 ILE   B H    1 
ATOM   4378 H  HA   . ILE   B 1 155 ? -21.899 13.068 27.698 1.00 17.09 ? 135 ILE   B HA   1 
ATOM   4379 H  HB   . ILE   B 1 155 ? -21.796 14.336 30.223 1.00 16.93 ? 135 ILE   B HB   1 
ATOM   4380 H  HG12 . ILE   B 1 155 ? -20.915 15.522 27.820 1.00 15.18 ? 135 ILE   B HG12 1 
ATOM   4381 H  HG13 . ILE   B 1 155 ? -22.394 15.757 28.350 1.00 15.18 ? 135 ILE   B HG13 1 
ATOM   4382 H  HG21 . ILE   B 1 155 ? -19.420 14.487 29.704 1.00 19.43 ? 135 ILE   B HG21 1 
ATOM   4383 H  HG22 . ILE   B 1 155 ? -19.936 13.051 30.137 1.00 19.43 ? 135 ILE   B HG22 1 
ATOM   4384 H  HG23 . ILE   B 1 155 ? -19.699 13.381 28.600 1.00 19.43 ? 135 ILE   B HG23 1 
ATOM   4385 H  HD11 . ILE   B 1 155 ? -21.168 17.566 29.021 1.00 17.40 ? 135 ILE   B HD11 1 
ATOM   4386 H  HD12 . ILE   B 1 155 ? -21.451 16.708 30.328 1.00 17.40 ? 135 ILE   B HD12 1 
ATOM   4387 H  HD13 . ILE   B 1 155 ? -20.030 16.635 29.623 1.00 17.40 ? 135 ILE   B HD13 1 
ATOM   4388 N  N    . LYS   B 1 156 ? -21.583 10.830 28.601 1.00 13.92 ? 136 LYS   B N    1 
ATOM   4389 C  CA   . LYS   B 1 156 ? -21.270 9.527  29.182 1.00 15.16 ? 136 LYS   B CA   1 
ATOM   4390 C  C    . LYS   B 1 156 ? -19.868 9.485  29.777 1.00 15.30 ? 136 LYS   B C    1 
ATOM   4391 O  O    . LYS   B 1 156 ? -19.659 8.816  30.796 1.00 16.40 ? 136 LYS   B O    1 
ATOM   4392 C  CB   . LYS   B 1 156 ? -21.445 8.450  28.103 1.00 17.77 ? 136 LYS   B CB   1 
ATOM   4393 C  CG   . LYS   B 1 156 ? -21.003 7.049  28.467 1.00 26.47 ? 136 LYS   B CG   1 
ATOM   4394 C  CD   . LYS   B 1 156 ? -21.949 6.386  29.452 1.00 38.40 ? 136 LYS   B CD   1 
ATOM   4395 C  CE   . LYS   B 1 156 ? -21.800 4.873  29.384 1.00 45.08 ? 136 LYS   B CE   1 
ATOM   4396 N  NZ   . LYS   B 1 156 ? -22.458 4.184  30.523 1.00 51.78 ? 136 LYS   B NZ   1 
ATOM   4397 H  H    . LYS   B 1 156 ? -21.359 10.897 27.773 1.00 16.72 ? 136 LYS   B H    1 
ATOM   4398 H  HA   . LYS   B 1 156 ? -21.901 9.340  29.894 1.00 18.21 ? 136 LYS   B HA   1 
ATOM   4399 H  HB2  . LYS   B 1 156 ? -22.385 8.404  27.870 1.00 21.34 ? 136 LYS   B HB2  1 
ATOM   4400 H  HB3  . LYS   B 1 156 ? -20.935 8.718  27.323 1.00 21.34 ? 136 LYS   B HB3  1 
ATOM   4401 H  HG2  . LYS   B 1 156 ? -20.987 6.508  27.662 1.00 31.78 ? 136 LYS   B HG2  1 
ATOM   4402 H  HG3  . LYS   B 1 156 ? -20.119 7.073  28.864 1.00 31.78 ? 136 LYS   B HG3  1 
ATOM   4403 H  HD2  . LYS   B 1 156 ? -21.736 6.677  30.353 1.00 46.10 ? 136 LYS   B HD2  1 
ATOM   4404 H  HD3  . LYS   B 1 156 ? -22.865 6.615  29.229 1.00 46.10 ? 136 LYS   B HD3  1 
ATOM   4405 H  HE2  . LYS   B 1 156 ? -22.205 4.551  28.563 1.00 54.11 ? 136 LYS   B HE2  1 
ATOM   4406 H  HE3  . LYS   B 1 156 ? -20.857 4.647  29.400 1.00 54.11 ? 136 LYS   B HE3  1 
ATOM   4407 H  HZ1  . LYS   B 1 156 ? -22.306 3.308  30.477 1.00 62.16 ? 136 LYS   B HZ1  1 
ATOM   4408 H  HZ2  . LYS   B 1 156 ? -22.136 4.494  31.293 1.00 62.16 ? 136 LYS   B HZ2  1 
ATOM   4409 H  HZ3  . LYS   B 1 156 ? -23.336 4.327  30.497 1.00 62.16 ? 136 LYS   B HZ3  1 
ATOM   4410 N  N    . GLU   B 1 157 ? -18.911 10.199 29.184 1.00 15.54 ? 137 GLU   B N    1 
ATOM   4411 C  CA   . GLU   B 1 157 ? -17.545 10.208 29.691 1.00 11.94 ? 137 GLU   B CA   1 
ATOM   4412 C  C    . GLU   B 1 157 ? -16.895 11.543 29.368 1.00 10.04 ? 137 GLU   B C    1 
ATOM   4413 O  O    . GLU   B 1 157 ? -16.789 11.918 28.197 1.00 13.39 ? 137 GLU   B O    1 
ATOM   4414 C  CB   . GLU   B 1 157 ? -16.719 9.070  29.090 1.00 16.15 ? 137 GLU   B CB   1 
ATOM   4415 C  CG   . GLU   B 1 157 ? -15.309 8.990  29.645 1.00 16.32 ? 137 GLU   B CG   1 
ATOM   4416 C  CD   . GLU   B 1 157 ? -14.409 8.110  28.809 1.00 21.55 ? 137 GLU   B CD   1 
ATOM   4417 O  OE1  . GLU   B 1 157 ? -14.139 8.471  27.643 1.00 18.13 ? 137 GLU   B OE1  1 
ATOM   4418 O  OE2  . GLU   B 1 157 ? -13.988 7.049  29.320 1.00 22.12 ? 137 GLU   B OE2  1 
ATOM   4419 H  H    . GLU   B 1 157 ? -19.030 10.686 28.486 1.00 18.67 ? 137 GLU   B H    1 
ATOM   4420 H  HA   . GLU   B 1 157 ? -17.558 10.097 30.653 1.00 14.34 ? 137 GLU   B HA   1 
ATOM   4421 H  HB2  . GLU   B 1 157 ? -17.161 8.228  29.278 1.00 19.40 ? 137 GLU   B HB2  1 
ATOM   4422 H  HB3  . GLU   B 1 157 ? -16.655 9.201  28.131 1.00 19.40 ? 137 GLU   B HB3  1 
ATOM   4423 H  HG2  . GLU   B 1 157 ? -14.916 9.876  29.668 1.00 19.61 ? 137 GLU   B HG2  1 
ATOM   4424 H  HG3  . GLU   B 1 157 ? -15.343 8.619  30.540 1.00 19.61 ? 137 GLU   B HG3  1 
ATOM   4425 N  N    . GLN   B 1 158 ? -16.458 12.244 30.406 1.00 12.33 ? 138 GLN   B N    1 
ATOM   4426 C  CA   . GLN   B 1 158 ? -15.655 13.454 30.290 1.00 11.69 ? 138 GLN   B CA   1 
ATOM   4427 C  C    . GLN   B 1 158 ? -14.289 13.153 30.893 1.00 11.34 ? 138 GLN   B C    1 
ATOM   4428 O  O    . GLN   B 1 158 ? -14.206 12.530 31.953 1.00 12.68 ? 138 GLN   B O    1 
ATOM   4429 C  CB   . GLN   B 1 158 ? -16.329 14.619 31.012 1.00 12.70 ? 138 GLN   B CB   1 
ATOM   4430 C  CG   . GLN   B 1 158 ? -15.526 15.912 31.008 1.00 11.67 ? 138 GLN   B CG   1 
ATOM   4431 C  CD   . GLN   B 1 158 ? -14.576 16.028 32.186 1.00 16.18 ? 138 GLN   B CD   1 
ATOM   4432 O  OE1  . GLN   B 1 158 ? -14.770 15.399 33.234 1.00 17.74 ? 138 GLN   B OE1  1 
ATOM   4433 N  NE2  . GLN   B 1 158 ? -13.551 16.850 32.029 1.00 18.04 ? 138 GLN   B NE2  1 
ATOM   4434 H  H    . GLN   B 1 158 ? -16.622 12.028 31.222 1.00 14.82 ? 138 GLN   B H    1 
ATOM   4435 H  HA   . GLN   B 1 158 ? -15.545 13.687 29.357 1.00 14.05 ? 138 GLN   B HA   1 
ATOM   4436 H  HB2  . GLN   B 1 158 ? -17.178 14.801 30.579 1.00 15.26 ? 138 GLN   B HB2  1 
ATOM   4437 H  HB3  . GLN   B 1 158 ? -16.483 14.365 31.935 1.00 15.26 ? 138 GLN   B HB3  1 
ATOM   4438 H  HG2  . GLN   B 1 158 ? -14.999 15.953 30.194 1.00 14.03 ? 138 GLN   B HG2  1 
ATOM   4439 H  HG3  . GLN   B 1 158 ? -16.139 16.663 31.043 1.00 14.03 ? 138 GLN   B HG3  1 
ATOM   4440 H  HE21 . GLN   B 1 158 ? -13.450 17.272 31.287 1.00 21.67 ? 138 GLN   B HE21 1 
ATOM   4441 H  HE22 . GLN   B 1 158 ? -12.982 16.955 32.665 1.00 21.67 ? 138 GLN   B HE22 1 
ATOM   4442 N  N    . ARG   B 1 159 ? -13.227 13.553 30.206 1.00 11.90 ? 139 ARG   B N    1 
ATOM   4443 C  CA   . ARG   B 1 159 ? -11.874 13.365 30.713 1.00 11.48 ? 139 ARG   B CA   1 
ATOM   4444 C  C    . ARG   B 1 159 ? -11.106 14.650 30.455 1.00 11.87 ? 139 ARG   B C    1 
ATOM   4445 O  O    . ARG   B 1 159 ? -11.225 15.229 29.371 1.00 11.33 ? 139 ARG   B O    1 
ATOM   4446 C  CB   . ARG   B 1 159 ? -11.153 12.195 30.037 1.00 13.45 ? 139 ARG   B CB   1 
ATOM   4447 C  CG   . ARG   B 1 159 ? -11.910 10.875 30.030 1.00 12.35 ? 139 ARG   B CG   1 
ATOM   4448 C  CD   . ARG   B 1 159 ? -11.151 9.851  29.182 1.00 13.12 ? 139 ARG   B CD   1 
ATOM   4449 N  NE   . ARG   B 1 159 ? -11.239 10.172 27.762 1.00 13.27 ? 139 ARG   B NE   1 
ATOM   4450 C  CZ   . ARG   B 1 159 ? -10.414 9.716  26.830 1.00 14.44 ? 139 ARG   B CZ   1 
ATOM   4451 N  NH1  . ARG   B 1 159 ? -9.421  8.891  27.129 1.00 13.72 ? 139 ARG   B NH1  1 
ATOM   4452 N  NH2  . ARG   B 1 159 ? -10.579 10.109 25.568 1.00 13.43 ? 139 ARG   B NH2  1 
ATOM   4453 H  H    . ARG   B 1 159 ? -13.263 13.939 29.438 1.00 14.29 ? 139 ARG   B H    1 
ATOM   4454 H  HA   . ARG   B 1 159 ? -11.899 13.205 31.669 1.00 13.80 ? 139 ARG   B HA   1 
ATOM   4455 H  HB2  . ARG   B 1 159 ? -10.978 12.435 29.114 1.00 16.16 ? 139 ARG   B HB2  1 
ATOM   4456 H  HB3  . ARG   B 1 159 ? -10.312 12.046 30.497 1.00 16.16 ? 139 ARG   B HB3  1 
ATOM   4457 H  HG2  . ARG   B 1 159 ? -11.982 10.536 30.935 1.00 14.83 ? 139 ARG   B HG2  1 
ATOM   4458 H  HG3  . ARG   B 1 159 ? -12.790 11.005 29.643 1.00 14.83 ? 139 ARG   B HG3  1 
ATOM   4459 H  HD2  . ARG   B 1 159 ? -10.216 9.854  29.439 1.00 15.76 ? 139 ARG   B HD2  1 
ATOM   4460 H  HD3  . ARG   B 1 159 ? -11.535 8.971  29.320 1.00 15.76 ? 139 ARG   B HD3  1 
ATOM   4461 H  HE   . ARG   B 1 159 ? -11.873 10.696 27.511 1.00 15.94 ? 139 ARG   B HE   1 
ATOM   4462 H  HH11 . ARG   B 1 159 ? -9.303  8.633  27.940 1.00 16.49 ? 139 ARG   B HH11 1 
ATOM   4463 H  HH12 . ARG   B 1 159 ? -8.897  8.609  26.509 1.00 16.49 ? 139 ARG   B HH12 1 
ATOM   4464 H  HH21 . ARG   B 1 159 ? -11.220 10.645 25.365 1.00 16.13 ? 139 ARG   B HH21 1 
ATOM   4465 H  HH22 . ARG   B 1 159 ? -10.050 9.820  24.955 1.00 16.13 ? 139 ARG   B HH22 1 
ATOM   4466 N  N    . GLU   B 1 160 ? -10.338 15.117 31.432 1.00 11.63 ? 140 GLU   B N    1 
ATOM   4467 C  CA   . GLU   B 1 160 ? -9.498  16.281 31.184 1.00 13.76 ? 140 GLU   B CA   1 
ATOM   4468 C  C    . GLU   B 1 160 ? -8.034  15.912 31.354 1.00 13.23 ? 140 GLU   B C    1 
ATOM   4469 O  O    . GLU   B 1 160 ? -7.674  15.079 32.194 1.00 11.94 ? 140 GLU   B O    1 
ATOM   4470 C  CB   . GLU   B 1 160 ? -9.858  17.479 32.054 1.00 20.88 ? 140 GLU   B CB   1 
ATOM   4471 C  CG   . GLU   B 1 160 ? -9.775  17.314 33.517 1.00 20.69 ? 140 GLU   B CG   1 
ATOM   4472 C  CD   . GLU   B 1 160 ? -10.666 18.326 34.218 1.00 33.55 ? 140 GLU   B CD   1 
ATOM   4473 O  OE1  . GLU   B 1 160 ? -11.908 18.249 34.078 1.00 29.78 ? 140 GLU   B OE1  1 
ATOM   4474 O  OE2  . GLU   B 1 160 ? -10.127 19.219 34.900 1.00 23.51 ? 140 GLU   B OE2  1 
ATOM   4475 H  H    . GLU   B 1 160 ? -10.285 14.789 32.225 1.00 13.97 ? 140 GLU   B H    1 
ATOM   4476 H  HA   . GLU   B 1 160 ? -9.611  16.560 30.263 1.00 16.54 ? 140 GLU   B HA   1 
ATOM   4477 H  HB2  . GLU   B 1 160 ? -9.267  18.210 31.817 1.00 25.07 ? 140 GLU   B HB2  1 
ATOM   4478 H  HB3  . GLU   B 1 160 ? -10.772 17.731 31.850 1.00 25.07 ? 140 GLU   B HB3  1 
ATOM   4479 H  HG2  . GLU   B 1 160 ? -10.073 16.423 33.759 1.00 24.84 ? 140 GLU   B HG2  1 
ATOM   4480 H  HG3  . GLU   B 1 160 ? -8.860  17.457 33.807 1.00 24.84 ? 140 GLU   B HG3  1 
ATOM   4481 N  N    . PHE   B 1 161 ? -7.207  16.517 30.511 1.00 10.93 ? 141 PHE   B N    1 
ATOM   4482 C  CA   . PHE   B 1 161 ? -5.792  16.211 30.415 1.00 10.95 ? 141 PHE   B CA   1 
ATOM   4483 C  C    . PHE   B 1 161 ? -5.019  17.511 30.546 1.00 11.53 ? 141 PHE   B C    1 
ATOM   4484 O  O    . PHE   B 1 161 ? -5.314  18.481 29.840 1.00 13.94 ? 141 PHE   B O    1 
ATOM   4485 C  CB   . PHE   B 1 161 ? -5.443  15.559 29.075 1.00 10.38 ? 141 PHE   B CB   1 
ATOM   4486 C  CG   . PHE   B 1 161 ? -6.212  14.309 28.776 1.00 12.20 ? 141 PHE   B CG   1 
ATOM   4487 C  CD1  . PHE   B 1 161 ? -7.485  14.373 28.225 1.00 14.20 ? 141 PHE   B CD1  1 
ATOM   4488 C  CD2  . PHE   B 1 161 ? -5.649  13.064 28.999 1.00 14.08 ? 141 PHE   B CD2  1 
ATOM   4489 C  CE1  . PHE   B 1 161 ? -8.187  13.221 27.931 1.00 11.79 ? 141 PHE   B CE1  1 
ATOM   4490 C  CE2  . PHE   B 1 161 ? -6.346  11.914 28.711 1.00 16.55 ? 141 PHE   B CE2  1 
ATOM   4491 C  CZ   . PHE   B 1 161 ? -7.614  11.991 28.177 1.00 12.48 ? 141 PHE   B CZ   1 
ATOM   4492 H  H    . PHE   B 1 161 ? -7.456  17.132 29.964 1.00 13.14 ? 141 PHE   B H    1 
ATOM   4493 H  HA   . PHE   B 1 161 ? -5.530  15.615 31.134 1.00 13.16 ? 141 PHE   B HA   1 
ATOM   4494 H  HB2  . PHE   B 1 161 ? -5.625  16.194 28.364 1.00 12.47 ? 141 PHE   B HB2  1 
ATOM   4495 H  HB3  . PHE   B 1 161 ? -4.500  15.331 29.077 1.00 12.47 ? 141 PHE   B HB3  1 
ATOM   4496 H  HD1  . PHE   B 1 161 ? -7.873  15.202 28.061 1.00 17.05 ? 141 PHE   B HD1  1 
ATOM   4497 H  HD2  . PHE   B 1 161 ? -4.795  13.005 29.362 1.00 16.92 ? 141 PHE   B HD2  1 
ATOM   4498 H  HE1  . PHE   B 1 161 ? -9.043  13.274 27.572 1.00 14.16 ? 141 PHE   B HE1  1 
ATOM   4499 H  HE2  . PHE   B 1 161 ? -5.960  11.084 28.874 1.00 19.88 ? 141 PHE   B HE2  1 
ATOM   4500 H  HZ   . PHE   B 1 161 ? -8.083  11.212 27.981 1.00 15.00 ? 141 PHE   B HZ   1 
ATOM   4501 N  N    . MET   B 1 162 ? -4.020  17.525 31.420 1.00 11.56 ? 142 MET   B N    1 
ATOM   4502 C  CA   . MET   B 1 162 ? -3.181  18.703 31.576 1.00 11.83 ? 142 MET   B CA   1 
ATOM   4503 C  C    . MET   B 1 162 ? -1.778  18.242 31.942 1.00 15.06 ? 142 MET   B C    1 
ATOM   4504 O  O    . MET   B 1 162 ? -1.497  17.044 32.018 1.00 13.56 ? 142 MET   B O    1 
ATOM   4505 C  CB   . MET   B 1 162 ? -3.779  19.668 32.606 1.00 12.89 ? 142 MET   B CB   1 
ATOM   4506 C  CG   . MET   B 1 162 ? -4.218  19.052 33.920 1.00 13.06 ? 142 MET   B CG   1 
ATOM   4507 S  SD   . MET   B 1 162 ? -2.815  18.373 34.818 1.00 14.46 ? 142 MET   B SD   1 
ATOM   4508 C  CE   . MET   B 1 162 ? -3.474  18.232 36.482 1.00 17.64 ? 142 MET   B CE   1 
ATOM   4509 H  H    . MET   B 1 162 ? -3.808  16.868 31.932 1.00 13.90 ? 142 MET   B H    1 
ATOM   4510 H  HA   . MET   B 1 162 ? -3.140  19.170 30.727 1.00 14.21 ? 142 MET   B HA   1 
ATOM   4511 H  HB2  . MET   B 1 162 ? -3.118  20.347 32.812 1.00 15.49 ? 142 MET   B HB2  1 
ATOM   4512 H  HB3  . MET   B 1 162 ? -4.558  20.089 32.211 1.00 15.49 ? 142 MET   B HB3  1 
ATOM   4513 H  HG2  . MET   B 1 162 ? -4.631  19.735 34.472 1.00 15.70 ? 142 MET   B HG2  1 
ATOM   4514 H  HG3  . MET   B 1 162 ? -4.847  18.334 33.746 1.00 15.70 ? 142 MET   B HG3  1 
ATOM   4515 H  HE1  . MET   B 1 162 ? -2.832  17.761 37.036 1.00 21.19 ? 142 MET   B HE1  1 
ATOM   4516 H  HE2  . MET   B 1 162 ? -3.627  19.122 36.836 1.00 21.19 ? 142 MET   B HE2  1 
ATOM   4517 H  HE3  . MET   B 1 162 ? -4.308  17.740 36.452 1.00 21.19 ? 142 MET   B HE3  1 
ATOM   4518 N  N    . ASN   B 1 163 ? -0.895  19.217 32.159 1.00 14.32 ? 143 ASN   B N    1 
ATOM   4519 C  CA   . ASN   B 1 163 ? 0.454   18.962 32.634 1.00 9.41  ? 143 ASN   B CA   1 
ATOM   4520 C  C    . ASN   B 1 163 ? 0.490   19.162 34.136 1.00 14.03 ? 143 ASN   B C    1 
ATOM   4521 O  O    . ASN   B 1 163 ? 0.424   20.313 34.599 1.00 12.32 ? 143 ASN   B O    1 
ATOM   4522 C  CB   . ASN   B 1 163 ? 1.435   19.905 31.952 1.00 13.67 ? 143 ASN   B CB   1 
ATOM   4523 C  CG   . ASN   B 1 163 ? 2.850   19.726 32.434 1.00 13.03 ? 143 ASN   B CG   1 
ATOM   4524 O  OD1  . ASN   B 1 163 ? 3.133   18.905 33.306 1.00 14.90 ? 143 ASN   B OD1  1 
ATOM   4525 N  ND2  . ASN   B 1 163 ? 3.761   20.492 31.847 1.00 15.05 ? 143 ASN   B ND2  1 
ATOM   4526 H  H    . ASN   B 1 163 ? -1.063  20.051 32.034 1.00 17.20 ? 143 ASN   B H    1 
ATOM   4527 H  HA   . ASN   B 1 163 ? 0.712   18.055 32.415 1.00 11.31 ? 143 ASN   B HA   1 
ATOM   4528 H  HB2  . ASN   B 1 163 ? 1.421   19.738 30.997 1.00 16.42 ? 143 ASN   B HB2  1 
ATOM   4529 H  HB3  . ASN   B 1 163 ? 1.170   20.821 32.133 1.00 16.42 ? 143 ASN   B HB3  1 
ATOM   4530 H  HD21 . ASN   B 1 163 ? 4.587   20.433 32.080 1.00 18.08 ? 143 ASN   B HD21 1 
ATOM   4531 H  HD22 . ASN   B 1 163 ? 3.525   21.052 31.239 1.00 18.08 ? 143 ASN   B HD22 1 
ATOM   4532 N  N    . PRO   B 1 164 ? 0.588   18.101 34.935 1.00 11.90 ? 144 PRO   B N    1 
ATOM   4533 C  CA   . PRO   B 1 164 ? 0.519   18.289 36.392 1.00 12.79 ? 144 PRO   B CA   1 
ATOM   4534 C  C    . PRO   B 1 164 ? 1.620   19.170 36.938 1.00 11.89 ? 144 PRO   B C    1 
ATOM   4535 O  O    . PRO   B 1 164 ? 1.456   19.714 38.038 1.00 12.42 ? 144 PRO   B O    1 
ATOM   4536 C  CB   . PRO   B 1 164 ? 0.600   16.858 36.941 1.00 14.90 ? 144 PRO   B CB   1 
ATOM   4537 C  CG   . PRO   B 1 164 ? 0.093   16.000 35.801 1.00 14.42 ? 144 PRO   B CG   1 
ATOM   4538 C  CD   . PRO   B 1 164 ? 0.587   16.676 34.556 1.00 11.99 ? 144 PRO   B CD   1 
ATOM   4539 H  HA   . PRO   B 1 164 ? -0.339  18.671 36.635 1.00 15.37 ? 144 PRO   B HA   1 
ATOM   4540 H  HB2  . PRO   B 1 164 ? 1.520   16.639 37.157 1.00 17.90 ? 144 PRO   B HB2  1 
ATOM   4541 H  HB3  . PRO   B 1 164 ? 0.030   16.771 37.721 1.00 17.90 ? 144 PRO   B HB3  1 
ATOM   4542 H  HG2  . PRO   B 1 164 ? 0.461   15.106 35.875 1.00 17.33 ? 144 PRO   B HG2  1 
ATOM   4543 H  HG3  . PRO   B 1 164 ? -0.877  15.975 35.816 1.00 17.33 ? 144 PRO   B HG3  1 
ATOM   4544 H  HD2  . PRO   B 1 164 ? 1.486   16.380 34.343 1.00 14.41 ? 144 PRO   B HD2  1 
ATOM   4545 H  HD3  . PRO   B 1 164 ? -0.026  16.515 33.823 1.00 14.41 ? 144 PRO   B HD3  1 
ATOM   4546 N  N    . CYS   B 1 165 ? 2.721   19.361 36.205 1.00 13.01 ? 145 CYS   B N    1 
ATOM   4547 C  CA   . CYS   B 1 165 ? 3.792   20.193 36.742 1.00 13.17 ? 145 CYS   B CA   1 
ATOM   4548 C  C    . CYS   B 1 165 ? 3.315   21.606 37.040 1.00 13.36 ? 145 CYS   B C    1 
ATOM   4549 O  O    . CYS   B 1 165 ? 3.772   22.215 38.013 1.00 12.69 ? 145 CYS   B O    1 
ATOM   4550 C  CB   . CYS   B 1 165 ? 4.977   20.225 35.776 1.00 15.06 ? 145 CYS   B CB   1 
ATOM   4551 S  SG   . CYS   B 1 165 ? 5.751   18.603 35.551 1.00 17.02 ? 145 CYS   B SG   1 
ATOM   4552 H  H    . CYS   B 1 165 ? 2.867   19.032 35.424 1.00 15.63 ? 145 CYS   B H    1 
ATOM   4553 H  HA   . CYS   B 1 165 ? 4.101   19.804 37.575 1.00 15.82 ? 145 CYS   B HA   1 
ATOM   4554 H  HB2  . CYS   B 1 165 ? 4.669   20.532 34.909 1.00 18.09 ? 145 CYS   B HB2  1 
ATOM   4555 H  HB3  . CYS   B 1 165 ? 5.650   20.832 36.122 1.00 18.09 ? 145 CYS   B HB3  1 
ATOM   4556 H  HG   . CYS   B 1 165 ? 6.311   18.552 34.493 1.00 20.44 ? 145 CYS   B HG   1 
ATOM   4557 N  N    . GLU   B 1 166 ? 2.399   22.146 36.235 1.00 13.76 ? 146 GLU   B N    1 
ATOM   4558 C  CA   . GLU   B 1 166 ? 1.887   23.482 36.530 1.00 14.50 ? 146 GLU   B CA   1 
ATOM   4559 C  C    . GLU   B 1 166 ? 1.012   23.488 37.780 1.00 16.35 ? 146 GLU   B C    1 
ATOM   4560 O  O    . GLU   B 1 166 ? 0.965   24.495 38.497 1.00 16.29 ? 146 GLU   B O    1 
ATOM   4561 C  CB   . GLU   B 1 166 ? 1.119   24.027 35.328 1.00 15.24 ? 146 GLU   B CB   1 
ATOM   4562 C  CG   . GLU   B 1 166 ? 2.002   24.254 34.118 1.00 18.55 ? 146 GLU   B CG   1 
ATOM   4563 C  CD   . GLU   B 1 166 ? 3.210   25.114 34.451 1.00 30.69 ? 146 GLU   B CD   1 
ATOM   4564 O  OE1  . GLU   B 1 166 ? 3.019   26.289 34.824 1.00 35.74 ? 146 GLU   B OE1  1 
ATOM   4565 O  OE2  . GLU   B 1 166 ? 4.350   24.608 34.388 1.00 44.66 ? 146 GLU   B OE2  1 
ATOM   4566 H  H    . GLU   B 1 166 ? 2.068   21.773 35.534 1.00 16.53 ? 146 GLU   B H    1 
ATOM   4567 H  HA   . GLU   B 1 166 ? 2.637   24.069 36.709 1.00 17.42 ? 146 GLU   B HA   1 
ATOM   4568 H  HB2  . GLU   B 1 166 ? 0.429   23.392 35.080 1.00 18.30 ? 146 GLU   B HB2  1 
ATOM   4569 H  HB3  . GLU   B 1 166 ? 0.717   24.876 35.569 1.00 18.30 ? 146 GLU   B HB3  1 
ATOM   4570 H  HG2  . GLU   B 1 166 ? 2.321   23.398 33.791 1.00 22.27 ? 146 GLU   B HG2  1 
ATOM   4571 H  HG3  . GLU   B 1 166 ? 1.489   24.706 33.429 1.00 22.27 ? 146 GLU   B HG3  1 
ATOM   4572 N  N    . GLN   B 1 167 ? 0.312   22.387 38.065 1.00 12.97 ? 147 GLN   B N    1 
ATOM   4573 C  CA   . GLN   B 1 167 ? -0.446  22.346 39.308 1.00 15.38 ? 147 GLN   B CA   1 
ATOM   4574 C  C    . GLN   B 1 167 ? 0.489   22.205 40.503 1.00 14.11 ? 147 GLN   B C    1 
ATOM   4575 O  O    . GLN   B 1 167 ? 0.238   22.789 41.562 1.00 16.25 ? 147 GLN   B O    1 
ATOM   4576 C  CB   . GLN   B 1 167 ? -1.462  21.212 39.296 1.00 11.24 ? 147 GLN   B CB   1 
ATOM   4577 C  CG   . GLN   B 1 167 ? -2.474  21.351 40.426 1.00 13.98 ? 147 GLN   B CG   1 
ATOM   4578 C  CD   . GLN   B 1 167 ? -3.662  20.439 40.275 1.00 16.14 ? 147 GLN   B CD   1 
ATOM   4579 O  OE1  . GLN   B 1 167 ? -3.914  19.896 39.199 1.00 16.53 ? 147 GLN   B OE1  1 
ATOM   4580 N  NE2  . GLN   B 1 167 ? -4.410  20.264 41.362 1.00 17.79 ? 147 GLN   B NE2  1 
ATOM   4581 H  H    . GLN   B 1 167 ? 0.262   21.681 37.576 1.00 15.58 ? 147 GLN   B H    1 
ATOM   4582 H  HA   . GLN   B 1 167 ? -0.932  23.180 39.407 1.00 18.47 ? 147 GLN   B HA   1 
ATOM   4583 H  HB2  . GLN   B 1 167 ? -1.943  21.224 38.454 1.00 13.50 ? 147 GLN   B HB2  1 
ATOM   4584 H  HB3  . GLN   B 1 167 ? -0.999  20.367 39.406 1.00 13.50 ? 147 GLN   B HB3  1 
ATOM   4585 H  HG2  . GLN   B 1 167 ? -2.039  21.137 41.266 1.00 16.80 ? 147 GLN   B HG2  1 
ATOM   4586 H  HG3  . GLN   B 1 167 ? -2.800  22.264 40.446 1.00 16.80 ? 147 GLN   B HG3  1 
ATOM   4587 H  HE21 . GLN   B 1 167 ? -4.202  20.661 42.096 1.00 21.36 ? 147 GLN   B HE21 1 
ATOM   4588 H  HE22 . GLN   B 1 167 ? -5.101  19.753 41.331 1.00 21.36 ? 147 GLN   B HE22 1 
ATOM   4589 N  N    . PHE   B 1 168 ? 1.574   21.434 40.352 1.00 12.91 ? 148 PHE   B N    1 
ATOM   4590 C  CA   . PHE   B 1 168 ? 2.588   21.391 41.401 1.00 12.30 ? 148 PHE   B CA   1 
ATOM   4591 C  C    . PHE   B 1 168 ? 3.072   22.801 41.729 1.00 16.26 ? 148 PHE   B C    1 
ATOM   4592 O  O    . PHE   B 1 168 ? 3.171   23.186 42.901 1.00 15.81 ? 148 PHE   B O    1 
ATOM   4593 C  CB   . PHE   B 1 168 ? 3.796   20.538 41.002 1.00 14.36 ? 148 PHE   B CB   1 
ATOM   4594 C  CG   . PHE   B 1 168 ? 3.489   19.097 40.729 1.00 11.87 ? 148 PHE   B CG   1 
ATOM   4595 C  CD1  . PHE   B 1 168 ? 2.348   18.490 41.225 1.00 15.51 ? 148 PHE   B CD1  1 
ATOM   4596 C  CD2  . PHE   B 1 168 ? 4.370   18.339 39.970 1.00 14.91 ? 148 PHE   B CD2  1 
ATOM   4597 C  CE1  . PHE   B 1 168 ? 2.082   17.159 40.958 1.00 21.92 ? 148 PHE   B CE1  1 
ATOM   4598 C  CE2  . PHE   B 1 168 ? 4.110   17.010 39.698 1.00 19.22 ? 148 PHE   B CE2  1 
ATOM   4599 C  CZ   . PHE   B 1 168 ? 2.968   16.417 40.195 1.00 25.64 ? 148 PHE   B CZ   1 
ATOM   4600 H  H    . PHE   B 1 168 ? 1.740   20.940 39.668 1.00 15.51 ? 148 PHE   B H    1 
ATOM   4601 H  HA   . PHE   B 1 168 ? 2.199   21.016 42.206 1.00 14.78 ? 148 PHE   B HA   1 
ATOM   4602 H  HB2  . PHE   B 1 168 ? 4.185   20.912 40.196 1.00 17.25 ? 148 PHE   B HB2  1 
ATOM   4603 H  HB3  . PHE   B 1 168 ? 4.446   20.568 41.721 1.00 17.25 ? 148 PHE   B HB3  1 
ATOM   4604 H  HD1  . PHE   B 1 168 ? 1.748   18.983 41.736 1.00 18.63 ? 148 PHE   B HD1  1 
ATOM   4605 H  HD2  . PHE   B 1 168 ? 5.140   18.734 39.630 1.00 17.91 ? 148 PHE   B HD2  1 
ATOM   4606 H  HE1  . PHE   B 1 168 ? 1.311   16.762 41.294 1.00 26.32 ? 148 PHE   B HE1  1 
ATOM   4607 H  HE2  . PHE   B 1 168 ? 4.708   16.514 39.187 1.00 23.08 ? 148 PHE   B HE2  1 
ATOM   4608 H  HZ   . PHE   B 1 168 ? 2.793   15.521 40.017 1.00 30.78 ? 148 PHE   B HZ   1 
ATOM   4609 N  N    . ARG   B 1 169 ? 3.398   23.581 40.691 1.00 14.94 ? 149 ARG   B N    1 
ATOM   4610 C  CA   . ARG   B 1 169 ? 3.894   24.935 40.914 1.00 17.38 ? 149 ARG   B CA   1 
ATOM   4611 C  C    . ARG   B 1 169 ? 2.889   25.777 41.688 1.00 17.08 ? 149 ARG   B C    1 
ATOM   4612 O  O    . ARG   B 1 169 ? 3.266   26.517 42.601 1.00 19.11 ? 149 ARG   B O    1 
ATOM   4613 C  CB   . ARG   B 1 169 ? 4.231   25.608 39.586 1.00 16.43 ? 149 ARG   B CB   1 
ATOM   4614 C  CG   . ARG   B 1 169 ? 5.494   25.066 38.964 1.00 21.41 ? 149 ARG   B CG   1 
ATOM   4615 C  CD   . ARG   B 1 169 ? 5.995   25.907 37.802 1.00 25.91 ? 149 ARG   B CD   1 
ATOM   4616 N  NE   . ARG   B 1 169 ? 7.327   25.441 37.439 1.00 31.46 ? 149 ARG   B NE   1 
ATOM   4617 C  CZ   . ARG   B 1 169 ? 7.569   24.440 36.605 1.00 28.06 ? 149 ARG   B CZ   1 
ATOM   4618 N  NH1  . ARG   B 1 169 ? 6.603   23.884 35.893 1.00 29.24 ? 149 ARG   B NH1  1 
ATOM   4619 N  NH2  . ARG   B 1 169 ? 8.811   23.980 36.488 1.00 32.57 ? 149 ARG   B NH2  1 
ATOM   4620 H  H    . ARG   B 1 169 ? 3.341   23.351 39.864 1.00 17.95 ? 149 ARG   B H    1 
ATOM   4621 H  HA   . ARG   B 1 169 ? 4.708   24.888 41.439 1.00 20.87 ? 149 ARG   B HA   1 
ATOM   4622 H  HB2  . ARG   B 1 169 ? 3.502   25.461 38.963 1.00 19.73 ? 149 ARG   B HB2  1 
ATOM   4623 H  HB3  . ARG   B 1 169 ? 4.354   26.559 39.735 1.00 19.73 ? 149 ARG   B HB3  1 
ATOM   4624 H  HG2  . ARG   B 1 169 ? 6.192   25.042 39.637 1.00 25.71 ? 149 ARG   B HG2  1 
ATOM   4625 H  HG3  . ARG   B 1 169 ? 5.323   24.171 38.633 1.00 25.71 ? 149 ARG   B HG3  1 
ATOM   4626 H  HD2  . ARG   B 1 169 ? 5.401   25.813 37.042 1.00 31.11 ? 149 ARG   B HD2  1 
ATOM   4627 H  HD3  . ARG   B 1 169 ? 6.056   26.836 38.075 1.00 31.11 ? 149 ARG   B HD3  1 
ATOM   4628 H  HE   . ARG   B 1 169 ? 8.002   25.843 37.790 1.00 37.77 ? 149 ARG   B HE   1 
ATOM   4629 H  HH11 . ARG   B 1 169 ? 5.794   24.164 35.963 1.00 35.10 ? 149 ARG   B HH11 1 
ATOM   4630 H  HH12 . ARG   B 1 169 ? 6.786   23.237 35.357 1.00 35.10 ? 149 ARG   B HH12 1 
ATOM   4631 H  HH21 . ARG   B 1 169 ? 9.447   24.338 36.943 1.00 39.10 ? 149 ARG   B HH21 1 
ATOM   4632 H  HH22 . ARG   B 1 169 ? 8.982   23.338 35.942 1.00 39.10 ? 149 ARG   B HH22 1 
ATOM   4633 N  N    . SER   B 1 170 ? 1.604   25.675 41.342 1.00 16.51 ? 150 SER   B N    1 
ATOM   4634 C  CA   . SER   B 1 170 ? 0.593   26.480 42.023 1.00 17.65 ? 150 SER   B CA   1 
ATOM   4635 C  C    . SER   B 1 170 ? 0.481   26.121 43.498 1.00 19.81 ? 150 SER   B C    1 
ATOM   4636 O  O    . SER   B 1 170 ? 0.025   26.944 44.299 1.00 19.50 ? 150 SER   B O    1 
ATOM   4637 C  CB   . SER   B 1 170 ? -0.769  26.312 41.342 1.00 16.80 ? 150 SER   B CB   1 
ATOM   4638 O  OG   . SER   B 1 170 ? -1.377  25.065 41.646 1.00 15.87 ? 150 SER   B OG   1 
ATOM   4639 H  H    . SER   B 1 170 ? 1.298   25.157 40.728 1.00 19.82 ? 150 SER   B H    1 
ATOM   4640 H  HA   . SER   B 1 170 ? 0.843   27.415 41.962 1.00 21.20 ? 150 SER   B HA   1 
ATOM   4641 H  HB2  . SER   B 1 170 ? -1.356  27.024 41.641 1.00 20.18 ? 150 SER   B HB2  1 
ATOM   4642 H  HB3  . SER   B 1 170 ? -0.646  26.371 40.382 1.00 20.18 ? 150 SER   B HB3  1 
ATOM   4643 H  HG   . SER   B 1 170 ? -0.884  24.435 41.390 1.00 19.07 ? 150 SER   B HG   1 
ATOM   4644 N  N    . LEU   B 1 171 ? 0.890   24.913 43.871 1.00 14.59 ? 151 LEU   B N    1 
ATOM   4645 C  CA   . LEU   B 1 171 ? 0.819   24.431 45.240 1.00 17.01 ? 151 LEU   B CA   1 
ATOM   4646 C  C    . LEU   B 1 171 ? 2.126   24.609 46.002 1.00 16.31 ? 151 LEU   B C    1 
ATOM   4647 O  O    . LEU   B 1 171 ? 2.203   24.220 47.170 1.00 18.93 ? 151 LEU   B O    1 
ATOM   4648 C  CB   . LEU   B 1 171 ? 0.423   22.953 45.243 1.00 13.39 ? 151 LEU   B CB   1 
ATOM   4649 C  CG   . LEU   B 1 171 ? -0.992  22.636 44.762 1.00 17.31 ? 151 LEU   B CG   1 
ATOM   4650 C  CD1  . LEU   B 1 171 ? -1.176  21.132 44.573 1.00 18.40 ? 151 LEU   B CD1  1 
ATOM   4651 C  CD2  . LEU   B 1 171 ? -2.037  23.184 45.724 1.00 19.35 ? 151 LEU   B CD2  1 
ATOM   4652 H  H    . LEU   B 1 171 ? 1.223   24.336 43.328 1.00 17.52 ? 151 LEU   B H    1 
ATOM   4653 H  HA   . LEU   B 1 171 ? 0.132   24.926 45.712 1.00 20.43 ? 151 LEU   B HA   1 
ATOM   4654 H  HB2  . LEU   B 1 171 ? 1.038   22.472 44.668 1.00 16.08 ? 151 LEU   B HB2  1 
ATOM   4655 H  HB3  . LEU   B 1 171 ? 0.501   22.618 46.150 1.00 16.08 ? 151 LEU   B HB3  1 
ATOM   4656 H  HG   . LEU   B 1 171 ? -1.131  23.061 43.901 1.00 20.79 ? 151 LEU   B HG   1 
ATOM   4657 H  HD11 . LEU   B 1 171 ? -2.081  20.961 44.268 1.00 22.09 ? 151 LEU   B HD11 1 
ATOM   4658 H  HD12 . LEU   B 1 171 ? -0.539  20.817 43.913 1.00 22.09 ? 151 LEU   B HD12 1 
ATOM   4659 H  HD13 . LEU   B 1 171 ? -1.023  20.687 45.421 1.00 22.09 ? 151 LEU   B HD13 1 
ATOM   4660 H  HD21 . LEU   B 1 171 ? -2.914  22.880 45.443 1.00 23.24 ? 151 LEU   B HD21 1 
ATOM   4661 H  HD22 . LEU   B 1 171 ? -1.845  22.858 46.617 1.00 23.24 ? 151 LEU   B HD22 1 
ATOM   4662 H  HD23 . LEU   B 1 171 ? -2.002  24.153 45.711 1.00 23.24 ? 151 LEU   B HD23 1 
ATOM   4663 N  N    . GLY   B 1 172 ? 3.153   25.174 45.373 1.00 14.61 ? 152 GLY   B N    1 
ATOM   4664 C  CA   . GLY   B 1 172 ? 4.448   25.314 46.004 1.00 18.27 ? 152 GLY   B CA   1 
ATOM   4665 C  C    . GLY   B 1 172 ? 5.256   24.040 46.069 1.00 20.33 ? 152 GLY   B C    1 
ATOM   4666 O  O    . GLY   B 1 172 ? 6.231   23.979 46.831 1.00 20.53 ? 152 GLY   B O    1 
ATOM   4667 H  H    . GLY   B 1 172 ? 3.120   25.486 44.572 1.00 17.55 ? 152 GLY   B H    1 
ATOM   4668 H  HA2  . GLY   B 1 172 ? 4.967   25.974 45.517 1.00 21.94 ? 152 GLY   B HA2  1 
ATOM   4669 H  HA3  . GLY   B 1 172 ? 4.324   25.637 46.910 1.00 21.94 ? 152 GLY   B HA3  1 
ATOM   4670 N  N    . ILE   B 1 173 ? 4.870   23.028 45.298 1.00 16.32 ? 153 ILE   B N    1 
ATOM   4671 C  CA   . ILE   B 1 173 ? 5.577   21.756 45.252 1.00 17.79 ? 153 ILE   B CA   1 
ATOM   4672 C  C    . ILE   B 1 173 ? 6.718   21.859 44.249 1.00 18.41 ? 153 ILE   B C    1 
ATOM   4673 O  O    . ILE   B 1 173 ? 6.527   22.332 43.121 1.00 17.11 ? 153 ILE   B O    1 
ATOM   4674 C  CB   . ILE   B 1 173 ? 4.605   20.634 44.862 1.00 15.33 ? 153 ILE   B CB   1 
ATOM   4675 C  CG1  . ILE   B 1 173 ? 3.493   20.497 45.905 1.00 13.87 ? 153 ILE   B CG1  1 
ATOM   4676 C  CG2  . ILE   B 1 173 ? 5.328   19.318 44.669 1.00 18.02 ? 153 ILE   B CG2  1 
ATOM   4677 C  CD1  . ILE   B 1 173 ? 2.402   19.559 45.482 1.00 19.23 ? 153 ILE   B CD1  1 
ATOM   4678 H  H    . ILE   B 1 173 ? 4.184   23.056 44.780 1.00 19.60 ? 153 ILE   B H    1 
ATOM   4679 H  HA   . ILE   B 1 173 ? 5.948   21.556 46.126 1.00 21.37 ? 153 ILE   B HA   1 
ATOM   4680 H  HB   . ILE   B 1 173 ? 4.194   20.876 44.017 1.00 18.41 ? 153 ILE   B HB   1 
ATOM   4681 H  HG12 . ILE   B 1 173 ? 3.875   20.158 46.730 1.00 16.66 ? 153 ILE   B HG12 1 
ATOM   4682 H  HG13 . ILE   B 1 173 ? 3.093   21.367 46.059 1.00 16.66 ? 153 ILE   B HG13 1 
ATOM   4683 H  HG21 . ILE   B 1 173 ? 4.678   18.613 44.528 1.00 21.64 ? 153 ILE   B HG21 1 
ATOM   4684 H  HG22 . ILE   B 1 173 ? 5.908   19.382 43.895 1.00 21.64 ? 153 ILE   B HG22 1 
ATOM   4685 H  HG23 . ILE   B 1 173 ? 5.853   19.128 45.462 1.00 21.64 ? 153 ILE   B HG23 1 
ATOM   4686 H  HD11 . ILE   B 1 173 ? 1.625   19.705 46.045 1.00 23.09 ? 153 ILE   B HD11 1 
ATOM   4687 H  HD12 . ILE   B 1 173 ? 2.177   19.735 44.555 1.00 23.09 ? 153 ILE   B HD12 1 
ATOM   4688 H  HD13 . ILE   B 1 173 ? 2.713   18.646 45.579 1.00 23.09 ? 153 ILE   B HD13 1 
ATOM   4689 N  N    . GLU   B 1 174 ? 7.900   21.396 44.653 1.00 19.68 ? 154 GLU   B N    1 
ATOM   4690 C  CA   . GLU   B 1 174 ? 9.071   21.409 43.784 1.00 18.01 ? 154 GLU   B CA   1 
ATOM   4691 C  C    . GLU   B 1 174 ? 8.873   20.468 42.604 1.00 17.99 ? 154 GLU   B C    1 
ATOM   4692 O  O    . GLU   B 1 174 ? 8.440   19.326 42.771 1.00 20.92 ? 154 GLU   B O    1 
ATOM   4693 C  CB   . GLU   B 1 174 ? 10.308  21.003 44.585 1.00 21.21 ? 154 GLU   B CB   1 
ATOM   4694 H  H    . GLU   B 1 174 ? 8.049   21.067 45.433 1.00 23.63 ? 154 GLU   B H    1 
ATOM   4695 H  HA   . GLU   B 1 174 ? 9.208   22.306 43.441 1.00 21.62 ? 154 GLU   B HA   1 
ATOM   4696 N  N    . VAL   B 1 175 ? 9.181   20.950 41.409 1.00 20.18 ? 155 VAL   B N    1 
ATOM   4697 C  CA   . VAL   B 1 175 ? 9.040   20.172 40.181 1.00 15.02 ? 155 VAL   B CA   1 
ATOM   4698 C  C    . VAL   B 1 175 ? 10.415  19.638 39.797 1.00 18.30 ? 155 VAL   B C    1 
ATOM   4699 O  O    . VAL   B 1 175 ? 11.366  20.428 39.702 1.00 18.20 ? 155 VAL   B O    1 
ATOM   4700 C  CB   . VAL   B 1 175 ? 8.444   21.016 39.039 1.00 17.31 ? 155 VAL   B CB   1 
ATOM   4701 C  CG1  . VAL   B 1 175 ? 8.387   20.215 37.738 1.00 18.12 ? 155 VAL   B CG1  1 
ATOM   4702 C  CG2  . VAL   B 1 175 ? 7.054   21.513 39.417 1.00 26.50 ? 155 VAL   B CG2  1 
ATOM   4703 H  H    . VAL   B 1 175 ? 9.481   21.745 41.278 1.00 24.24 ? 155 VAL   B H    1 
ATOM   4704 H  HA   . VAL   B 1 175 ? 8.441   19.429 40.347 1.00 18.05 ? 155 VAL   B HA   1 
ATOM   4705 H  HB   . VAL   B 1 175 ? 9.009   21.790 38.890 1.00 20.79 ? 155 VAL   B HB   1 
ATOM   4706 H  HG11 . VAL   B 1 175 ? 7.836   20.693 37.099 1.00 21.76 ? 155 VAL   B HG11 1 
ATOM   4707 H  HG12 . VAL   B 1 175 ? 9.285   20.113 37.387 1.00 21.76 ? 155 VAL   B HG12 1 
ATOM   4708 H  HG13 . VAL   B 1 175 ? 8.000   19.345 37.920 1.00 21.76 ? 155 VAL   B HG13 1 
ATOM   4709 H  HG21 . VAL   B 1 175 ? 6.687   22.019 38.675 1.00 31.81 ? 155 VAL   B HG21 1 
ATOM   4710 H  HG22 . VAL   B 1 175 ? 6.488   20.749 39.609 1.00 31.81 ? 155 VAL   B HG22 1 
ATOM   4711 H  HG23 . VAL   B 1 175 ? 7.123   22.079 40.201 1.00 31.81 ? 155 VAL   B HG23 1 
ATOM   4712 N  N    . PRO   B 1 176 ? 10.572  18.332 39.586 1.00 22.07 ? 156 PRO   B N    1 
ATOM   4713 C  CA   . PRO   B 1 176 ? 11.877  17.835 39.148 1.00 24.60 ? 156 PRO   B CA   1 
ATOM   4714 C  C    . PRO   B 1 176 ? 12.213  18.382 37.773 1.00 21.53 ? 156 PRO   B C    1 
ATOM   4715 O  O    . PRO   B 1 176 ? 11.336  18.711 36.972 1.00 20.22 ? 156 PRO   B O    1 
ATOM   4716 C  CB   . PRO   B 1 176 ? 11.700  16.314 39.125 1.00 31.39 ? 156 PRO   B CB   1 
ATOM   4717 C  CG   . PRO   B 1 176 ? 10.267  16.111 38.916 1.00 34.63 ? 156 PRO   B CG   1 
ATOM   4718 C  CD   . PRO   B 1 176 ? 9.566   17.253 39.629 1.00 27.64 ? 156 PRO   B CD   1 
ATOM   4719 H  HA   . PRO   B 1 176 ? 12.571  18.078 39.781 1.00 29.53 ? 156 PRO   B HA   1 
ATOM   4720 H  HB2  . PRO   B 1 176 ? 12.211  15.938 38.392 1.00 37.68 ? 156 PRO   B HB2  1 
ATOM   4721 H  HB3  . PRO   B 1 176 ? 11.982  15.938 39.973 1.00 37.68 ? 156 PRO   B HB3  1 
ATOM   4722 H  HG2  . PRO   B 1 176 ? 10.077  16.136 37.966 1.00 41.57 ? 156 PRO   B HG2  1 
ATOM   4723 H  HG3  . PRO   B 1 176 ? 10.001  15.258 39.295 1.00 41.57 ? 156 PRO   B HG3  1 
ATOM   4724 H  HD2  . PRO   B 1 176 ? 8.766   17.513 39.146 1.00 33.18 ? 156 PRO   B HD2  1 
ATOM   4725 H  HD3  . PRO   B 1 176 ? 9.367   17.010 40.547 1.00 33.18 ? 156 PRO   B HD3  1 
ATOM   4726 N  N    . GLU   B 1 177 ? 13.504  18.488 37.513 0.97 28.71 ? 157 GLU   B N    1 
ATOM   4727 C  CA   . GLU   B 1 177 ? 14.006  18.967 36.238 0.97 29.22 ? 157 GLU   B CA   1 
ATOM   4728 C  C    . GLU   B 1 177 ? 14.764  17.825 35.583 0.97 26.29 ? 157 GLU   B C    1 
ATOM   4729 O  O    . GLU   B 1 177 ? 15.632  17.213 36.213 0.97 32.23 ? 157 GLU   B O    1 
ATOM   4730 C  CB   . GLU   B 1 177 ? 14.911  20.184 36.425 0.97 41.85 ? 157 GLU   B CB   1 
ATOM   4731 C  CG   . GLU   B 1 177 ? 15.398  20.788 35.119 0.97 46.49 ? 157 GLU   B CG   1 
ATOM   4732 C  CD   . GLU   B 1 177 ? 16.323  21.973 35.325 0.97 57.56 ? 157 GLU   B CD   1 
ATOM   4733 O  OE1  . GLU   B 1 177 ? 16.457  22.435 36.477 0.97 51.81 ? 157 GLU   B OE1  1 
ATOM   4734 O  OE2  . GLU   B 1 177 ? 16.920  22.441 34.332 0.97 75.56 ? 157 GLU   B OE2  1 
ATOM   4735 H  H    . GLU   B 1 177 ? 14.124  18.284 38.072 0.97 34.46 ? 157 GLU   B H    1 
ATOM   4736 H  HA   . GLU   B 1 177 ? 13.266  19.217 35.663 0.97 35.08 ? 157 GLU   B HA   1 
ATOM   4737 H  HB2  . GLU   B 1 177 ? 14.419  20.869 36.904 0.97 50.24 ? 157 GLU   B HB2  1 
ATOM   4738 H  HB3  . GLU   B 1 177 ? 15.690  19.919 36.938 0.97 50.24 ? 157 GLU   B HB3  1 
ATOM   4739 H  HG2  . GLU   B 1 177 ? 15.885  20.114 34.619 0.97 55.81 ? 157 GLU   B HG2  1 
ATOM   4740 H  HG3  . GLU   B 1 177 ? 14.632  21.092 34.607 0.97 55.81 ? 157 GLU   B HG3  1 
ATOM   4741 N  N    . VAL   B 1 178 ? 14.409  17.518 34.339 1.00 21.77 ? 158 VAL   B N    1 
ATOM   4742 C  CA   . VAL   B 1 178 ? 15.223  16.616 33.535 1.00 18.96 ? 158 VAL   B CA   1 
ATOM   4743 C  C    . VAL   B 1 178 ? 16.480  17.365 33.117 1.00 19.82 ? 158 VAL   B C    1 
ATOM   4744 O  O    . VAL   B 1 178 ? 16.405  18.475 32.579 1.00 20.11 ? 158 VAL   B O    1 
ATOM   4745 C  CB   . VAL   B 1 178 ? 14.428  16.116 32.323 1.00 18.68 ? 158 VAL   B CB   1 
ATOM   4746 C  CG1  . VAL   B 1 178 ? 15.279  15.220 31.440 1.00 23.27 ? 158 VAL   B CG1  1 
ATOM   4747 C  CG2  . VAL   B 1 178 ? 13.167  15.381 32.788 1.00 22.58 ? 158 VAL   B CG2  1 
ATOM   4748 H  H    . VAL   B 1 178 ? 13.707  17.816 33.941 1.00 26.14 ? 158 VAL   B H    1 
ATOM   4749 H  HA   . VAL   B 1 178 ? 15.484  15.850 34.070 1.00 22.77 ? 158 VAL   B HA   1 
ATOM   4750 H  HB   . VAL   B 1 178 ? 14.150  16.879 31.793 1.00 22.43 ? 158 VAL   B HB   1 
ATOM   4751 H  HG11 . VAL   B 1 178 ? 14.708  14.792 30.783 1.00 27.94 ? 158 VAL   B HG11 1 
ATOM   4752 H  HG12 . VAL   B 1 178 ? 15.950  15.759 30.992 1.00 27.94 ? 158 VAL   B HG12 1 
ATOM   4753 H  HG13 . VAL   B 1 178 ? 15.707  14.547 31.993 1.00 27.94 ? 158 VAL   B HG13 1 
ATOM   4754 H  HG21 . VAL   B 1 178 ? 12.712  15.015 32.014 1.00 27.11 ? 158 VAL   B HG21 1 
ATOM   4755 H  HG22 . VAL   B 1 178 ? 13.424  14.665 33.390 1.00 27.11 ? 158 VAL   B HG22 1 
ATOM   4756 H  HG23 . VAL   B 1 178 ? 12.586  16.008 33.247 1.00 27.11 ? 158 VAL   B HG23 1 
ATOM   4757 N  N    . ARG   B 1 179 ? 17.640  16.780 33.393 1.00 20.34 ? 159 ARG   B N    1 
ATOM   4758 C  CA   . ARG   B 1 179 ? 18.899  17.399 32.999 1.00 26.45 ? 159 ARG   B CA   1 
ATOM   4759 C  C    . ARG   B 1 179 ? 19.047  17.356 31.484 1.00 19.65 ? 159 ARG   B C    1 
ATOM   4760 O  O    . ARG   B 1 179 ? 18.921  16.291 30.873 1.00 21.25 ? 159 ARG   B O    1 
ATOM   4761 C  CB   . ARG   B 1 179 ? 20.073  16.682 33.654 1.00 24.97 ? 159 ARG   B CB   1 
ATOM   4762 C  CG   . ARG   B 1 179 ? 20.050  16.693 35.162 1.00 28.20 ? 159 ARG   B CG   1 
ATOM   4763 C  CD   . ARG   B 1 179 ? 21.296  16.031 35.723 1.00 27.23 ? 159 ARG   B CD   1 
ATOM   4764 N  NE   . ARG   B 1 179 ? 21.385  14.625 35.340 1.00 28.85 ? 159 ARG   B NE   1 
ATOM   4765 C  CZ   . ARG   B 1 179 ? 20.857  13.627 36.036 1.00 35.44 ? 159 ARG   B CZ   1 
ATOM   4766 N  NH1  . ARG   B 1 179 ? 20.183  13.845 37.153 1.00 31.94 ? 159 ARG   B NH1  1 
ATOM   4767 N  NH2  . ARG   B 1 179 ? 21.010  12.380 35.600 1.00 37.88 ? 159 ARG   B NH2  1 
ATOM   4768 H  H    . ARG   B 1 179 ? 17.725  16.030 33.805 1.00 24.43 ? 159 ARG   B H    1 
ATOM   4769 H  HA   . ARG   B 1 179 ? 18.907  18.326 33.283 1.00 31.75 ? 159 ARG   B HA   1 
ATOM   4770 H  HB2  . ARG   B 1 179 ? 20.070  15.756 33.366 1.00 29.98 ? 159 ARG   B HB2  1 
ATOM   4771 H  HB3  . ARG   B 1 179 ? 20.896  17.110 33.369 1.00 29.98 ? 159 ARG   B HB3  1 
ATOM   4772 H  HG2  . ARG   B 1 179 ? 20.022  17.610 35.478 1.00 33.85 ? 159 ARG   B HG2  1 
ATOM   4773 H  HG3  . ARG   B 1 179 ? 19.274  16.203 35.476 1.00 33.85 ? 159 ARG   B HG3  1 
ATOM   4774 H  HD2  . ARG   B 1 179 ? 22.078  16.486 35.373 1.00 32.70 ? 159 ARG   B HD2  1 
ATOM   4775 H  HD3  . ARG   B 1 179 ? 21.285  16.091 36.691 1.00 32.70 ? 159 ARG   B HD3  1 
ATOM   4776 H  HE   . ARG   B 1 179 ? 21.807  14.431 34.616 1.00 34.63 ? 159 ARG   B HE   1 
ATOM   4777 H  HH11 . ARG   B 1 179 ? 20.076  14.645 37.447 1.00 38.35 ? 159 ARG   B HH11 1 
ATOM   4778 H  HH12 . ARG   B 1 179 ? 19.849  13.182 37.587 1.00 38.35 ? 159 ARG   B HH12 1 
ATOM   4779 H  HH21 . ARG   B 1 179 ? 21.446  12.228 34.875 1.00 45.47 ? 159 ARG   B HH21 1 
ATOM   4780 H  HH22 . ARG   B 1 179 ? 20.671  11.725 36.043 1.00 45.47 ? 159 ARG   B HH22 1 
ATOM   4781 N  N    . ARG   B 1 180 ? 19.336  18.507 30.878 1.00 23.40 ? 160 ARG   B N    1 
ATOM   4782 C  CA   . ARG   B 1 180 ? 19.331  18.636 29.427 1.00 24.22 ? 160 ARG   B CA   1 
ATOM   4783 C  C    . ARG   B 1 180 ? 20.709  18.903 28.839 1.00 23.46 ? 160 ARG   B C    1 
ATOM   4784 O  O    . ARG   B 1 180 ? 20.815  19.161 27.633 1.00 22.24 ? 160 ARG   B O    1 
ATOM   4785 C  CB   . ARG   B 1 180 ? 18.373  19.752 29.006 1.00 26.16 ? 160 ARG   B CB   1 
ATOM   4786 C  CG   . ARG   B 1 180 ? 16.961  19.568 29.536 1.00 27.49 ? 160 ARG   B CG   1 
ATOM   4787 C  CD   . ARG   B 1 180 ? 15.987  20.513 28.872 1.00 31.44 ? 160 ARG   B CD   1 
ATOM   4788 N  NE   . ARG   B 1 180 ? 14.662  20.413 29.472 1.00 44.91 ? 160 ARG   B NE   1 
ATOM   4789 C  CZ   . ARG   B 1 180 ? 13.643  21.206 29.171 1.00 37.43 ? 160 ARG   B CZ   1 
ATOM   4790 N  NH1  . ARG   B 1 180 ? 13.768  22.187 28.293 1.00 42.03 ? 160 ARG   B NH1  1 
ATOM   4791 N  NH2  . ARG   B 1 180 ? 12.471  21.009 29.768 1.00 42.79 ? 160 ARG   B NH2  1 
ATOM   4792 H  H    . ARG   B 1 180 ? 19.540  19.233 31.291 1.00 28.10 ? 160 ARG   B H    1 
ATOM   4793 H  HA   . ARG   B 1 180 ? 19.005  17.809 29.041 1.00 29.08 ? 160 ARG   B HA   1 
ATOM   4794 H  HB2  . ARG   B 1 180 ? 18.709  20.598 29.342 1.00 31.41 ? 160 ARG   B HB2  1 
ATOM   4795 H  HB3  . ARG   B 1 180 ? 18.327  19.777 28.037 1.00 31.41 ? 160 ARG   B HB3  1 
ATOM   4796 H  HG2  . ARG   B 1 180 ? 16.670  18.659 29.361 1.00 33.01 ? 160 ARG   B HG2  1 
ATOM   4797 H  HG3  . ARG   B 1 180 ? 16.952  19.745 30.490 1.00 33.01 ? 160 ARG   B HG3  1 
ATOM   4798 H  HD2  . ARG   B 1 180 ? 16.302  21.425 28.974 1.00 37.74 ? 160 ARG   B HD2  1 
ATOM   4799 H  HD3  . ARG   B 1 180 ? 15.913  20.284 27.933 1.00 37.74 ? 160 ARG   B HD3  1 
ATOM   4800 H  HE   . ARG   B 1 180 ? 14.494  19.715 29.945 1.00 53.91 ? 160 ARG   B HE   1 
ATOM   4801 H  HH11 . ARG   B 1 180 ? 14.521  22.323 27.901 1.00 50.46 ? 160 ARG   B HH11 1 
ATOM   4802 H  HH12 . ARG   B 1 180 ? 13.094  22.690 28.113 1.00 50.46 ? 160 ARG   B HH12 1 
ATOM   4803 H  HH21 . ARG   B 1 180 ? 12.382  20.374 30.341 1.00 51.36 ? 160 ARG   B HH21 1 
ATOM   4804 H  HH22 . ARG   B 1 180 ? 11.803  21.518 29.582 1.00 51.36 ? 160 ARG   B HH22 1 
ATOM   4805 N  N    . ASP   B 1 181 ? 21.762  18.848 29.655 1.00 25.20 ? 161 ASP   B N    1 
ATOM   4806 C  CA   . ASP   B 1 181 ? 23.102  19.139 29.159 1.00 26.26 ? 161 ASP   B CA   1 
ATOM   4807 C  C    . ASP   B 1 181 ? 23.469  18.230 28.000 1.00 29.61 ? 161 ASP   B C    1 
ATOM   4808 O  O    . ASP   B 1 181 ? 24.083  18.670 27.020 1.00 26.15 ? 161 ASP   B O    1 
ATOM   4809 C  CB   . ASP   B 1 181 ? 24.119  18.978 30.284 1.00 28.10 ? 161 ASP   B CB   1 
ATOM   4810 C  CG   . ASP   B 1 181 ? 23.750  19.775 31.505 1.00 39.45 ? 161 ASP   B CG   1 
ATOM   4811 O  OD1  . ASP   B 1 181 ? 22.989  19.256 32.352 1.00 38.50 ? 161 ASP   B OD1  1 
ATOM   4812 O  OD2  . ASP   B 1 181 ? 24.212  20.929 31.596 1.00 40.87 ? 161 ASP   B OD2  1 
ATOM   4813 H  H    . ASP   B 1 181 ? 21.726  18.644 30.489 1.00 30.25 ? 161 ASP   B H    1 
ATOM   4814 H  HA   . ASP   B 1 181 ? 23.136  20.057 28.848 1.00 31.53 ? 161 ASP   B HA   1 
ATOM   4815 H  HB2  . ASP   B 1 181 ? 24.167  18.043 30.537 1.00 33.74 ? 161 ASP   B HB2  1 
ATOM   4816 H  HB3  . ASP   B 1 181 ? 24.986  19.284 29.975 1.00 33.74 ? 161 ASP   B HB3  1 
ATOM   4817 N  N    . GLY   B 1 182 ? 23.111  16.955 28.100 1.00 22.47 ? 162 GLY   B N    1 
ATOM   4818 C  CA   . GLY   B 1 182 ? 23.457  16.013 27.061 1.00 23.63 ? 162 GLY   B CA   1 
ATOM   4819 C  C    . GLY   B 1 182 ? 22.551  16.045 25.864 1.00 23.39 ? 162 GLY   B C    1 
ATOM   4820 O  O    . GLY   B 1 182 ? 22.832  15.367 24.871 1.00 23.66 ? 162 GLY   B O    1 
ATOM   4821 H  H    . GLY   B 1 182 ? 22.670  16.618 28.757 1.00 26.98 ? 162 GLY   B H    1 
ATOM   4822 H  HA2  . GLY   B 1 182 ? 24.361  16.194 26.758 1.00 28.38 ? 162 GLY   B HA2  1 
ATOM   4823 H  HA3  . GLY   B 1 182 ? 23.437  15.116 27.429 1.00 28.38 ? 162 GLY   B HA3  1 
ATOM   4824 N  N    . LEU   B 1 183 ? 21.480  16.816 25.933 1.00 25.78 ? 163 LEU   B N    1 
ATOM   4825 C  CA   . LEU   B 1 183 ? 20.480  16.857 24.886 1.00 24.21 ? 163 LEU   B CA   1 
ATOM   4826 C  C    . LEU   B 1 183 ? 20.734  18.031 23.959 1.00 28.08 ? 163 LEU   B C    1 
ATOM   4827 O  O    . LEU   B 1 183 ? 21.362  19.021 24.345 1.00 28.04 ? 163 LEU   B O    1 
ATOM   4828 C  CB   . LEU   B 1 183 ? 19.081  16.966 25.492 1.00 25.28 ? 163 LEU   B CB   1 
ATOM   4829 C  CG   . LEU   B 1 183 ? 18.648  15.770 26.343 1.00 23.93 ? 163 LEU   B CG   1 
ATOM   4830 C  CD1  . LEU   B 1 183 ? 17.407  16.101 27.153 1.00 33.75 ? 163 LEU   B CD1  1 
ATOM   4831 C  CD2  . LEU   B 1 183 ? 18.398  14.545 25.478 1.00 29.79 ? 163 LEU   B CD2  1 
ATOM   4832 H  H    . LEU   B 1 183 ? 21.305  17.338 26.593 1.00 30.95 ? 163 LEU   B H    1 
ATOM   4833 H  HA   . LEU   B 1 183 ? 20.529  16.037 24.372 1.00 29.07 ? 163 LEU   B HA   1 
ATOM   4834 H  HB2  . LEU   B 1 183 ? 19.055  17.752 26.060 1.00 30.35 ? 163 LEU   B HB2  1 
ATOM   4835 H  HB3  . LEU   B 1 183 ? 18.435  17.064 24.776 1.00 30.35 ? 163 LEU   B HB3  1 
ATOM   4836 H  HG   . LEU   B 1 183 ? 19.360  15.554 26.965 1.00 28.73 ? 163 LEU   B HG   1 
ATOM   4837 H  HD11 . LEU   B 1 183 ? 17.254  15.394 27.799 1.00 40.52 ? 163 LEU   B HD11 1 
ATOM   4838 H  HD12 . LEU   B 1 183 ? 17.543  16.944 27.611 1.00 40.52 ? 163 LEU   B HD12 1 
ATOM   4839 H  HD13 . LEU   B 1 183 ? 16.649  16.172 26.552 1.00 40.52 ? 163 LEU   B HD13 1 
ATOM   4840 H  HD21 . LEU   B 1 183 ? 18.062  13.828 26.037 1.00 35.76 ? 163 LEU   B HD21 1 
ATOM   4841 H  HD22 . LEU   B 1 183 ? 17.744  14.768 24.797 1.00 35.76 ? 163 LEU   B HD22 1 
ATOM   4842 H  HD23 . LEU   B 1 183 ? 19.232  14.277 25.061 1.00 35.76 ? 163 LEU   B HD23 1 
ATOM   4843 N  N    . PRO   B 1 184 ? 20.263  17.950 22.718 1.00 30.51 ? 164 PRO   B N    1 
ATOM   4844 C  CA   . PRO   B 1 184 ? 20.535  19.034 21.767 1.00 34.12 ? 164 PRO   B CA   1 
ATOM   4845 C  C    . PRO   B 1 184 ? 19.895  20.340 22.210 1.00 39.16 ? 164 PRO   B C    1 
ATOM   4846 O  O    . PRO   B 1 184 ? 18.854  20.360 22.873 1.00 36.45 ? 164 PRO   B O    1 
ATOM   4847 C  CB   . PRO   B 1 184 ? 19.931  18.523 20.451 1.00 32.66 ? 164 PRO   B CB   1 
ATOM   4848 C  CG   . PRO   B 1 184 ? 18.958  17.458 20.849 1.00 38.85 ? 164 PRO   B CG   1 
ATOM   4849 C  CD   . PRO   B 1 184 ? 19.508  16.840 22.107 1.00 38.53 ? 164 PRO   B CD   1 
ATOM   4850 H  HA   . PRO   B 1 184 ? 21.491  19.160 21.658 1.00 40.96 ? 164 PRO   B HA   1 
ATOM   4851 H  HB2  . PRO   B 1 184 ? 19.476  19.250 19.997 1.00 39.21 ? 164 PRO   B HB2  1 
ATOM   4852 H  HB3  . PRO   B 1 184 ? 20.632  18.154 19.892 1.00 39.21 ? 164 PRO   B HB3  1 
ATOM   4853 H  HG2  . PRO   B 1 184 ? 18.091  17.858 21.018 1.00 46.64 ? 164 PRO   B HG2  1 
ATOM   4854 H  HG3  . PRO   B 1 184 ? 18.896  16.795 20.143 1.00 46.64 ? 164 PRO   B HG3  1 
ATOM   4855 H  HD2  . PRO   B 1 184 ? 18.785  16.555 22.686 1.00 46.25 ? 164 PRO   B HD2  1 
ATOM   4856 H  HD3  . PRO   B 1 184 ? 20.102  16.105 21.891 1.00 46.25 ? 164 PRO   B HD3  1 
ATOM   4857 N  N    . SER   B 1 185 ? 20.545  21.439 21.847 0.98 52.78 ? 165 SER   B N    1 
ATOM   4858 C  CA   . SER   B 1 185 ? 20.059  22.773 22.177 0.98 60.93 ? 165 SER   B CA   1 
ATOM   4859 C  C    . SER   B 1 185 ? 20.452  23.748 21.069 0.98 76.67 ? 165 SER   B C    1 
ATOM   4860 O  O    . SER   B 1 185 ? 20.954  23.348 20.016 0.98 69.77 ? 165 SER   B O    1 
ATOM   4861 C  CB   . SER   B 1 185 ? 20.616  23.234 23.522 0.98 61.56 ? 165 SER   B CB   1 
ATOM   4862 O  OXT  . SER   B 1 185 ? 20.276  24.959 21.195 0.98 93.05 ? 165 SER   B OXT  1 
ATOM   4863 H  H    . SER   B 1 185 ? 21.281  21.439 21.402 0.98 63.36 ? 165 SER   B H    1 
ATOM   4864 H  HA   . SER   B 1 185 ? 19.091  22.756 22.238 0.98 73.14 ? 165 SER   B HA   1 
HETATM 4865 C  C1   . GOL   C 2 .   ? 8.243   10.899 22.982 1.00 28.67 ? 201 GOL   A C1   1 
HETATM 4866 O  O1   . GOL   C 2 .   ? 7.519   12.049 23.345 1.00 22.33 ? 201 GOL   A O1   1 
HETATM 4867 C  C2   . GOL   C 2 .   ? 8.033   10.621 21.480 1.00 33.84 ? 201 GOL   A C2   1 
HETATM 4868 O  O2   . GOL   C 2 .   ? 7.986   11.736 20.679 1.00 25.40 ? 201 GOL   A O2   1 
HETATM 4869 C  C3   . GOL   C 2 .   ? 9.246   9.714  21.118 1.00 27.61 ? 201 GOL   A C3   1 
HETATM 4870 O  O3   . GOL   C 2 .   ? 9.413   9.778  19.720 1.00 32.51 ? 201 GOL   A O3   1 
HETATM 4871 H  H11  . GOL   C 2 .   ? 7.974   10.117 23.490 1.00 34.42 ? 201 GOL   A H11  1 
HETATM 4872 H  H12  . GOL   C 2 .   ? 9.183   11.016 23.174 1.00 34.42 ? 201 GOL   A H12  1 
HETATM 4873 H  HO1  . GOL   C 2 .   ? 6.957   12.188 22.722 1.00 26.82 ? 201 GOL   A HO1  1 
HETATM 4874 H  H2   . GOL   C 2 .   ? 7.197   10.154 21.334 1.00 40.62 ? 201 GOL   A H2   1 
HETATM 4875 H  HO2  . GOL   C 2 .   ? 7.169   11.923 20.539 1.00 30.49 ? 201 GOL   A HO2  1 
HETATM 4876 H  H31  . GOL   C 2 .   ? 9.089   8.820  21.454 1.00 33.15 ? 201 GOL   A H31  1 
HETATM 4877 H  H32  . GOL   C 2 .   ? 10.028  10.021 21.575 1.00 33.15 ? 201 GOL   A H32  1 
HETATM 4878 H  HO3  . GOL   C 2 .   ? 9.187   10.562 19.483 1.00 39.03 ? 201 GOL   A HO3  1 
HETATM 4879 C  C1   . GOL   D 2 .   ? -3.881  26.806 19.806 1.00 39.85 ? 202 GOL   A C1   1 
HETATM 4880 O  O1   . GOL   D 2 .   ? -4.895  25.897 19.500 1.00 36.70 ? 202 GOL   A O1   1 
HETATM 4881 C  C2   . GOL   D 2 .   ? -3.200  27.168 18.473 1.00 36.01 ? 202 GOL   A C2   1 
HETATM 4882 O  O2   . GOL   D 2 .   ? -2.156  28.070 18.657 1.00 52.47 ? 202 GOL   A O2   1 
HETATM 4883 C  C3   . GOL   D 2 .   ? -2.703  25.832 17.889 1.00 28.22 ? 202 GOL   A C3   1 
HETATM 4884 O  O3   . GOL   D 2 .   ? -2.033  26.129 16.703 1.00 25.25 ? 202 GOL   A O3   1 
HETATM 4885 H  H11  . GOL   D 2 .   ? -3.223  26.446 20.421 1.00 47.84 ? 202 GOL   A H11  1 
HETATM 4886 H  H12  . GOL   D 2 .   ? -4.232  27.606 20.228 1.00 47.84 ? 202 GOL   A H12  1 
HETATM 4887 H  HO1  . GOL   D 2 .   ? -4.646  25.145 19.808 1.00 44.06 ? 202 GOL   A HO1  1 
HETATM 4888 H  H2   . GOL   D 2 .   ? -3.827  27.601 17.873 1.00 43.23 ? 202 GOL   A H2   1 
HETATM 4889 H  HO2  . GOL   D 2 .   ? -1.427  27.634 18.631 1.00 62.99 ? 202 GOL   A HO2  1 
HETATM 4890 H  H31  . GOL   D 2 .   ? -3.453  25.231 17.771 1.00 33.88 ? 202 GOL   A H31  1 
HETATM 4891 H  H32  . GOL   D 2 .   ? -2.124  25.394 18.532 1.00 33.88 ? 202 GOL   A H32  1 
HETATM 4892 H  HO3  . GOL   D 2 .   ? -1.870  25.387 16.322 1.00 30.31 ? 202 GOL   A HO3  1 
HETATM 4893 C  C1   . A1IAM E 3 .   ? 12.122  17.382 29.645 1.00 20.26 ? 203 A1IAM A C1   1 
HETATM 4894 O  O1   . A1IAM E 3 .   ? 11.289  13.747 25.791 1.00 22.01 ? 203 A1IAM A O1   1 
HETATM 4895 S  S1   . A1IAM E 3 .   ? 13.917  17.452 27.491 1.00 21.63 ? 203 A1IAM A S1   1 
HETATM 4896 C  C2   . A1IAM E 3 .   ? 10.916  16.937 30.174 1.00 16.07 ? 203 A1IAM A C2   1 
HETATM 4897 O  O2   . A1IAM E 3 .   ? 10.490  17.355 31.399 1.00 20.68 ? 203 A1IAM A O2   1 
HETATM 4898 C  C3   . A1IAM E 3 .   ? 10.111  16.071 29.450 1.00 15.04 ? 203 A1IAM A C3   1 
HETATM 4899 C  C4   . A1IAM E 3 .   ? 10.488  15.680 28.183 1.00 17.26 ? 203 A1IAM A C4   1 
HETATM 4900 C  C5   . A1IAM E 3 .   ? 11.701  16.079 27.636 1.00 15.15 ? 203 A1IAM A C5   1 
HETATM 4901 C  C6   . A1IAM E 3 .   ? 12.498  16.959 28.377 1.00 14.72 ? 203 A1IAM A C6   1 
HETATM 4902 C  C7   . A1IAM E 3 .   ? 12.271  15.799 26.350 1.00 20.72 ? 203 A1IAM A C7   1 
HETATM 4903 C  C8   . A1IAM E 3 .   ? 13.449  16.471 26.134 1.00 17.35 ? 203 A1IAM A C8   1 
HETATM 4904 C  C9   . A1IAM E 3 .   ? 14.282  16.513 24.911 1.00 20.12 ? 203 A1IAM A C9   1 
HETATM 4905 C  C10  . A1IAM E 3 .   ? 14.511  15.361 24.173 1.00 21.06 ? 203 A1IAM A C10  1 
HETATM 4906 C  C11  . A1IAM E 3 .   ? 15.322  15.393 23.052 1.00 26.87 ? 203 A1IAM A C11  1 
HETATM 4907 C  C12  . A1IAM E 3 .   ? 15.887  16.578 22.639 1.00 25.99 ? 203 A1IAM A C12  1 
HETATM 4908 C  C13  . A1IAM E 3 .   ? 15.655  17.730 23.356 1.00 29.72 ? 203 A1IAM A C13  1 
HETATM 4909 C  C14  . A1IAM E 3 .   ? 14.845  17.704 24.476 1.00 25.64 ? 203 A1IAM A C14  1 
HETATM 4910 C  C15  . A1IAM E 3 .   ? 11.600  14.872 25.417 1.00 14.83 ? 203 A1IAM A C15  1 
HETATM 4911 C  C16  . A1IAM E 3 .   ? 11.184  15.330 24.067 1.00 16.09 ? 203 A1IAM A C16  1 
HETATM 4912 C  C17  . A1IAM E 3 .   ? 11.424  16.626 23.623 1.00 15.53 ? 203 A1IAM A C17  1 
HETATM 4913 C  C18  . A1IAM E 3 .   ? 11.026  17.024 22.359 1.00 18.48 ? 203 A1IAM A C18  1 
HETATM 4914 C  C19  . A1IAM E 3 .   ? 10.384  16.120 21.543 1.00 19.10 ? 203 A1IAM A C19  1 
HETATM 4915 C  C20  . A1IAM E 3 .   ? 10.134  14.833 21.956 1.00 22.31 ? 203 A1IAM A C20  1 
HETATM 4916 C  C21  . A1IAM E 3 .   ? 10.517  14.450 23.226 1.00 19.58 ? 203 A1IAM A C21  1 
HETATM 4917 CL CL1  . A1IAM E 3 .   ? 9.867   16.622 19.958 1.00 30.02 ? 203 A1IAM A CL1  1 
HETATM 4918 H  H1   . A1IAM E 3 .   ? 12.706  17.985 30.150 1.00 24.32 ? 203 A1IAM A H1   1 
HETATM 4919 H  H13  . A1IAM E 3 .   ? 11.067  17.888 31.724 1.00 24.83 ? 203 A1IAM A H13  1 
HETATM 4920 H  H2   . A1IAM E 3 .   ? 9.276   15.738 29.839 1.00 18.07 ? 203 A1IAM A H2   1 
HETATM 4921 H  H3   . A1IAM E 3 .   ? 9.822   15.113 27.743 1.00 20.73 ? 203 A1IAM A H3   1 
HETATM 4922 H  H4   . A1IAM E 3 .   ? 14.148  14.471 24.357 1.00 25.29 ? 203 A1IAM A H4   1 
HETATM 4923 H  H5   . A1IAM E 3 .   ? 15.491  14.567 22.555 1.00 32.26 ? 203 A1IAM A H5   1 
HETATM 4924 H  H6   . A1IAM E 3 .   ? 16.451  16.600 21.839 1.00 31.20 ? 203 A1IAM A H6   1 
HETATM 4925 H  H7   . A1IAM E 3 .   ? 16.064  18.573 23.074 1.00 35.68 ? 203 A1IAM A H7   1 
HETATM 4926 H  H8   . A1IAM E 3 .   ? 14.714  18.570 24.913 1.00 30.79 ? 203 A1IAM A H8   1 
HETATM 4927 H  H9   . A1IAM E 3 .   ? 11.869  17.325 24.143 1.00 18.66 ? 203 A1IAM A H9   1 
HETATM 4928 H  H10  . A1IAM E 3 .   ? 11.201  17.938 22.054 1.00 22.19 ? 203 A1IAM A H10  1 
HETATM 4929 H  H11  . A1IAM E 3 .   ? 9.691   14.189 21.366 1.00 26.79 ? 203 A1IAM A H11  1 
HETATM 4930 H  H12  . A1IAM E 3 .   ? 10.295  13.536 23.497 1.00 23.52 ? 203 A1IAM A H12  1 
HETATM 4931 C  C1   . GOL   F 2 .   ? -11.028 22.811 38.058 1.00 23.74 ? 201 GOL   B C1   1 
HETATM 4932 O  O1   . GOL   F 2 .   ? -12.405 22.676 38.329 1.00 26.67 ? 201 GOL   B O1   1 
HETATM 4933 C  C2   . GOL   F 2 .   ? -10.502 21.406 37.695 1.00 20.85 ? 201 GOL   B C2   1 
HETATM 4934 O  O2   . GOL   F 2 .   ? -11.346 20.791 36.796 1.00 23.31 ? 201 GOL   B O2   1 
HETATM 4935 C  C3   . GOL   F 2 .   ? -9.098  21.652 37.154 1.00 21.53 ? 201 GOL   B C3   1 
HETATM 4936 O  O3   . GOL   F 2 .   ? -8.542  20.390 36.886 1.00 20.73 ? 201 GOL   B O3   1 
HETATM 4937 H  H11  . GOL   F 2 .   ? -10.527 23.162 38.810 1.00 28.50 ? 201 GOL   B H11  1 
HETATM 4938 H  H12  . GOL   F 2 .   ? -10.870 23.419 37.326 1.00 28.50 ? 201 GOL   B H12  1 
HETATM 4939 H  HO1  . GOL   F 2 .   ? -12.690 22.050 37.829 1.00 32.02 ? 201 GOL   B HO1  1 
HETATM 4940 H  H2   . GOL   F 2 .   ? -10.480 20.834 38.478 1.00 25.04 ? 201 GOL   B H2   1 
HETATM 4941 H  HO2  . GOL   F 2 .   ? -10.871 20.322 36.270 1.00 27.99 ? 201 GOL   B HO2  1 
HETATM 4942 H  H31  . GOL   F 2 .   ? -8.593  22.176 37.796 1.00 25.85 ? 201 GOL   B H31  1 
HETATM 4943 H  H32  . GOL   F 2 .   ? -9.149  22.202 36.357 1.00 25.85 ? 201 GOL   B H32  1 
HETATM 4944 H  HO3  . GOL   F 2 .   ? -8.692  20.226 36.066 1.00 24.90 ? 201 GOL   B HO3  1 
HETATM 4945 C  C1   . A1IAM G 3 .   ? -3.224  15.097 42.447 1.00 16.38 ? 202 A1IAM B C1   1 
HETATM 4946 O  O1   . A1IAM G 3 .   ? -6.834  18.732 40.870 1.00 20.95 ? 202 A1IAM B O1   1 
HETATM 4947 S  S1   . A1IAM G 3 .   ? -5.649  15.093 43.858 1.00 19.41 ? 202 A1IAM B S1   1 
HETATM 4948 C  C2   . A1IAM G 3 .   ? -2.472  15.560 41.374 1.00 15.23 ? 202 A1IAM B C2   1 
HETATM 4949 O  O2   . A1IAM G 3 .   ? -1.202  15.109 41.177 1.00 18.47 ? 202 A1IAM B O2   1 
HETATM 4950 C  C3   . A1IAM G 3 .   ? -3.017  16.466 40.475 1.00 15.65 ? 202 A1IAM B C3   1 
HETATM 4951 C  C4   . A1IAM G 3 .   ? -4.300  16.935 40.667 1.00 14.89 ? 202 A1IAM B C4   1 
HETATM 4952 C  C5   . A1IAM G 3 .   ? -5.094  16.465 41.706 1.00 13.72 ? 202 A1IAM B C5   1 
HETATM 4953 C  C6   . A1IAM G 3 .   ? -4.524  15.561 42.611 1.00 14.73 ? 202 A1IAM B C6   1 
HETATM 4954 C  C7   . A1IAM G 3 .   ? -6.467  16.746 42.030 1.00 18.14 ? 202 A1IAM B C7   1 
HETATM 4955 C  C8   . A1IAM G 3 .   ? -6.892  16.086 43.157 1.00 17.68 ? 202 A1IAM B C8   1 
HETATM 4956 C  C9   . A1IAM G 3 .   ? -8.228  16.071 43.800 1.00 17.84 ? 202 A1IAM B C9   1 
HETATM 4957 C  C10  . A1IAM G 3 .   ? -8.816  14.871 44.179 1.00 26.80 ? 202 A1IAM B C10  1 
HETATM 4958 C  C11  . A1IAM G 3 .   ? -10.085 14.854 44.731 1.00 26.39 ? 202 A1IAM B C11  1 
HETATM 4959 C  C12  . A1IAM G 3 .   ? -10.789 16.027 44.889 1.00 28.08 ? 202 A1IAM B C12  1 
HETATM 4960 C  C13  . A1IAM G 3 .   ? -10.220 17.222 44.506 1.00 27.75 ? 202 A1IAM B C13  1 
HETATM 4961 C  C14  . A1IAM G 3 .   ? -8.943  17.248 43.977 1.00 22.99 ? 202 A1IAM B C14  1 
HETATM 4962 C  C15  . A1IAM G 3 .   ? -7.275  17.625 41.165 1.00 16.59 ? 202 A1IAM B C15  1 
HETATM 4963 C  C16  . A1IAM G 3 .   ? -8.567  17.158 40.584 1.00 19.29 ? 202 A1IAM B C16  1 
HETATM 4964 C  C17  . A1IAM G 3 .   ? -8.992  15.836 40.696 1.00 16.91 ? 202 A1IAM B C17  1 
HETATM 4965 C  C18  . A1IAM G 3 .   ? -10.140 15.406 40.054 1.00 17.98 ? 202 A1IAM B C18  1 
HETATM 4966 C  C19  . A1IAM G 3 .   ? -10.871 16.304 39.305 1.00 20.68 ? 202 A1IAM B C19  1 
HETATM 4967 C  C20  . A1IAM G 3 .   ? -10.474 17.615 39.177 1.00 22.75 ? 202 A1IAM B C20  1 
HETATM 4968 C  C21  . A1IAM G 3 .   ? -9.337  18.042 39.838 1.00 21.00 ? 202 A1IAM B C21  1 
HETATM 4969 CL CL1  . A1IAM G 3 .   ? -12.353 15.785 38.554 1.00 29.61 ? 202 A1IAM B CL1  1 
HETATM 4970 H  H1   . A1IAM G 3 .   ? -2.854  14.453 43.085 1.00 19.67 ? 202 A1IAM B H1   1 
HETATM 4971 H  H13  . A1IAM G 3 .   ? -1.011  14.551 41.789 1.00 22.19 ? 202 A1IAM B H13  1 
HETATM 4972 H  H2   . A1IAM G 3 .   ? -2.492  16.771 39.707 1.00 18.80 ? 202 A1IAM B H2   1 
HETATM 4973 H  H3   . A1IAM G 3 .   ? -4.564  17.609 40.008 1.00 17.89 ? 202 A1IAM B H3   1 
HETATM 4974 H  H4   . A1IAM G 3 .   ? -8.421  13.979 44.100 1.00 32.18 ? 202 A1IAM B H4   1 
HETATM 4975 H  H5   . A1IAM G 3 .   ? -10.479 14.002 45.009 1.00 31.69 ? 202 A1IAM B H5   1 
HETATM 4976 H  H6   . A1IAM G 3 .   ? -11.690 16.010 45.272 1.00 33.71 ? 202 A1IAM B H6   1 
HETATM 4977 H  H7   . A1IAM G 3 .   ? -10.719 18.058 44.608 1.00 33.32 ? 202 A1IAM B H7   1 
HETATM 4978 H  H8   . A1IAM G 3 .   ? -8.607  18.139 43.749 1.00 27.61 ? 202 A1IAM B H8   1 
HETATM 4979 H  H9   . A1IAM G 3 .   ? -8.535  15.141 41.212 1.00 20.31 ? 202 A1IAM B H9   1 
HETATM 4980 H  H10  . A1IAM G 3 .   ? -10.425 14.473 40.134 1.00 21.60 ? 202 A1IAM B H10  1 
HETATM 4981 H  H11  . A1IAM G 3 .   ? -10.983 18.246 38.628 1.00 27.32 ? 202 A1IAM B H11  1 
HETATM 4982 H  H12  . A1IAM G 3 .   ? -9.107  18.990 39.753 1.00 25.22 ? 202 A1IAM B H12  1 
HETATM 4983 O  O    . HOH   H 4 .   ? 0.670   26.886 18.624 1.00 33.25 ? 301 HOH   A O    1 
HETATM 4984 O  O    . HOH   H 4 .   ? -1.665  12.479 45.001 1.00 26.74 ? 302 HOH   A O    1 
HETATM 4985 O  O    . HOH   H 4 .   ? -4.895  -1.687 24.008 1.00 38.35 ? 303 HOH   A O    1 
HETATM 4986 O  O    . HOH   H 4 .   ? 1.743   1.260  24.264 1.00 31.28 ? 304 HOH   A O    1 
HETATM 4987 O  O    . HOH   H 4 .   ? 2.993   10.810 1.879  1.00 38.75 ? 305 HOH   A O    1 
HETATM 4988 O  O    . HOH   H 4 .   ? 3.160   25.540 2.761  1.00 41.29 ? 306 HOH   A O    1 
HETATM 4989 O  O    . HOH   H 4 .   ? 5.830   12.914 17.539 1.00 23.82 ? 307 HOH   A O    1 
HETATM 4990 O  O    . HOH   H 4 .   ? -4.205  25.625 6.396  1.00 43.98 ? 308 HOH   A O    1 
HETATM 4991 O  O    . HOH   H 4 .   ? -8.575  11.270 53.914 1.00 41.49 ? 309 HOH   A O    1 
HETATM 4992 O  O    . HOH   H 4 .   ? -15.590 20.662 6.123  1.00 38.56 ? 310 HOH   A O    1 
HETATM 4993 O  O    . HOH   H 4 .   ? 3.498   26.565 15.778 1.00 31.45 ? 311 HOH   A O    1 
HETATM 4994 O  O    . HOH   H 4 .   ? -8.722  21.323 -1.060 1.00 36.84 ? 312 HOH   A O    1 
HETATM 4995 O  O    . HOH   H 4 .   ? -7.921  8.540  43.401 1.00 41.93 ? 313 HOH   A O    1 
HETATM 4996 O  O    . HOH   H 4 .   ? 10.093  7.744  40.063 1.00 26.55 ? 314 HOH   A O    1 
HETATM 4997 O  O    . HOH   H 4 .   ? 20.570  6.017  29.123 1.00 33.68 ? 315 HOH   A O    1 
HETATM 4998 O  O    . HOH   H 4 .   ? 0.028   11.091 29.545 1.00 20.51 ? 316 HOH   A O    1 
HETATM 4999 O  O    . HOH   H 4 .   ? 12.291  14.637 42.023 1.00 40.34 ? 317 HOH   A O    1 
HETATM 5000 O  O    . HOH   H 4 .   ? 7.419   12.235 26.130 1.00 18.58 ? 318 HOH   A O    1 
HETATM 5001 O  O    . HOH   H 4 .   ? 4.864   1.100  10.695 1.00 38.66 ? 319 HOH   A O    1 
HETATM 5002 O  O    . HOH   H 4 .   ? -8.115  9.532  3.962  1.00 32.94 ? 320 HOH   A O    1 
HETATM 5003 O  O    . HOH   H 4 .   ? 20.325  4.297  21.604 1.00 35.02 ? 321 HOH   A O    1 
HETATM 5004 O  O    . HOH   H 4 .   ? -6.503  5.641  22.078 1.00 22.68 ? 322 HOH   A O    1 
HETATM 5005 O  O    . HOH   H 4 .   ? 16.912  14.693 37.214 1.00 26.65 ? 323 HOH   A O    1 
HETATM 5006 O  O    . HOH   H 4 .   ? 15.794  4.972  33.910 1.00 25.12 ? 324 HOH   A O    1 
HETATM 5007 O  O    . HOH   H 4 .   ? -10.302 17.445 9.868  1.00 17.68 ? 325 HOH   A O    1 
HETATM 5008 O  O    . HOH   H 4 .   ? -1.056  21.578 16.168 1.00 12.92 ? 326 HOH   A O    1 
HETATM 5009 O  O    . HOH   H 4 .   ? 1.933   -1.262 26.604 1.00 29.30 ? 327 HOH   A O    1 
HETATM 5010 O  O    . HOH   H 4 .   ? 17.584  8.698  37.709 1.00 28.64 ? 328 HOH   A O    1 
HETATM 5011 O  O    . HOH   H 4 .   ? 5.985   8.548  14.237 1.00 18.94 ? 329 HOH   A O    1 
HETATM 5012 O  O    . HOH   H 4 .   ? -8.725  25.262 7.269  1.00 29.06 ? 330 HOH   A O    1 
HETATM 5013 O  O    . HOH   H 4 .   ? 12.039  3.886  22.139 1.00 15.94 ? 331 HOH   A O    1 
HETATM 5014 O  O    . HOH   H 4 .   ? 16.158  18.312 19.178 1.00 31.65 ? 332 HOH   A O    1 
HETATM 5015 O  O    . HOH   H 4 .   ? 10.851  3.210  16.111 1.00 22.77 ? 333 HOH   A O    1 
HETATM 5016 O  O    . HOH   H 4 .   ? -10.239 25.899 12.964 1.00 40.87 ? 334 HOH   A O    1 
HETATM 5017 O  O    . HOH   H 4 .   ? 8.689   29.093 25.660 1.00 50.62 ? 335 HOH   A O    1 
HETATM 5018 O  O    . HOH   H 4 .   ? 11.408  24.784 26.267 1.00 49.02 ? 336 HOH   A O    1 
HETATM 5019 O  O    . HOH   H 4 .   ? -6.124  24.431 11.124 1.00 27.80 ? 337 HOH   A O    1 
HETATM 5020 O  O    . HOH   H 4 .   ? 17.293  6.818  29.998 1.00 21.34 ? 338 HOH   A O    1 
HETATM 5021 O  O    . HOH   H 4 .   ? 4.405   4.232  15.408 1.00 24.32 ? 339 HOH   A O    1 
HETATM 5022 O  O    . HOH   H 4 .   ? 8.895   8.859  17.171 1.00 32.70 ? 340 HOH   A O    1 
HETATM 5023 O  O    . HOH   H 4 .   ? -3.831  24.891 3.201  1.00 40.84 ? 341 HOH   A O    1 
HETATM 5024 O  O    . HOH   H 4 .   ? 7.317   16.134 17.867 1.00 38.31 ? 342 HOH   A O    1 
HETATM 5025 O  O    . HOH   H 4 .   ? 7.584   16.123 1.087  1.00 25.59 ? 343 HOH   A O    1 
HETATM 5026 O  O    . HOH   H 4 .   ? 16.896  13.149 9.504  1.00 24.41 ? 344 HOH   A O    1 
HETATM 5027 O  O    . HOH   H 4 .   ? 12.622  13.322 10.254 1.00 22.20 ? 345 HOH   A O    1 
HETATM 5028 O  O    . HOH   H 4 .   ? 6.942   8.407  6.917  1.00 33.88 ? 346 HOH   A O    1 
HETATM 5029 O  O    . HOH   H 4 .   ? -11.723 11.961 5.682  1.00 40.62 ? 347 HOH   A O    1 
HETATM 5030 O  O    . HOH   H 4 .   ? 7.778   18.670 0.067  1.00 24.23 ? 348 HOH   A O    1 
HETATM 5031 O  O    . HOH   H 4 .   ? 9.059   14.594 12.443 1.00 30.71 ? 349 HOH   A O    1 
HETATM 5032 O  O    . HOH   H 4 .   ? 13.997  0.564  10.461 1.00 41.37 ? 350 HOH   A O    1 
HETATM 5033 O  O    . HOH   H 4 .   ? 13.852  24.024 7.054  1.00 45.18 ? 351 HOH   A O    1 
HETATM 5034 O  O    . HOH   H 4 .   ? 5.098   22.344 29.250 1.00 23.93 ? 352 HOH   A O    1 
HETATM 5035 O  O    . HOH   H 4 .   ? 9.149   8.505  6.701  1.00 35.75 ? 353 HOH   A O    1 
HETATM 5036 O  O    . HOH   H 4 .   ? 11.202  12.598 19.406 1.00 29.63 ? 354 HOH   A O    1 
HETATM 5037 O  O    . HOH   H 4 .   ? 11.503  14.588 12.411 1.00 31.09 ? 355 HOH   A O    1 
HETATM 5038 O  O    . HOH   H 4 .   ? 0.836   -1.342 15.862 1.00 30.83 ? 356 HOH   A O    1 
HETATM 5039 O  O    . HOH   H 4 .   ? -2.322  12.006 28.848 1.00 25.37 ? 357 HOH   A O    1 
HETATM 5040 O  O    . HOH   H 4 .   ? 14.785  12.056 41.705 1.00 29.69 ? 358 HOH   A O    1 
HETATM 5041 O  O    . HOH   H 4 .   ? 15.812  6.072  40.743 1.00 46.60 ? 359 HOH   A O    1 
HETATM 5042 O  O    . HOH   H 4 .   ? -3.720  11.915 -0.754 1.00 32.08 ? 360 HOH   A O    1 
HETATM 5043 O  O    . HOH   H 4 .   ? -4.000  20.778 3.287  1.00 32.16 ? 361 HOH   A O    1 
HETATM 5044 O  O    . HOH   H 4 .   ? -4.006  25.007 9.583  1.00 28.15 ? 362 HOH   A O    1 
HETATM 5045 O  O    . HOH   H 4 .   ? 13.968  24.765 16.586 1.00 34.92 ? 363 HOH   A O    1 
HETATM 5046 O  O    . HOH   H 4 .   ? 6.677   24.548 2.504  1.00 28.61 ? 364 HOH   A O    1 
HETATM 5047 O  O    . HOH   H 4 .   ? 11.004  10.055 15.700 1.00 28.21 ? 365 HOH   A O    1 
HETATM 5048 O  O    . HOH   H 4 .   ? 19.688  1.347  22.367 1.00 46.93 ? 366 HOH   A O    1 
HETATM 5049 O  O    . HOH   H 4 .   ? 14.834  24.347 10.575 1.00 34.98 ? 367 HOH   A O    1 
HETATM 5050 O  O    . HOH   H 4 .   ? -8.299  5.976  13.840 1.00 30.48 ? 368 HOH   A O    1 
HETATM 5051 O  O    . HOH   H 4 .   ? 7.635   3.106  9.309  1.00 26.29 ? 369 HOH   A O    1 
HETATM 5052 O  O    . HOH   H 4 .   ? -4.566  17.185 51.718 1.00 30.07 ? 370 HOH   A O    1 
HETATM 5053 O  O    . HOH   H 4 .   ? 11.161  11.495 13.379 1.00 32.03 ? 371 HOH   A O    1 
HETATM 5054 O  O    . HOH   H 4 .   ? -14.765 14.998 4.866  1.00 42.14 ? 372 HOH   A O    1 
HETATM 5055 O  O    . HOH   H 4 .   ? 11.074  25.522 22.177 1.00 30.20 ? 373 HOH   A O    1 
HETATM 5056 O  O    . HOH   H 4 .   ? 7.686   5.757  16.121 1.00 28.68 ? 374 HOH   A O    1 
HETATM 5057 O  O    . HOH   H 4 .   ? 7.478   16.189 14.768 1.00 33.76 ? 375 HOH   A O    1 
HETATM 5058 O  O    . HOH   H 4 .   ? 20.634  8.242  15.662 1.00 43.09 ? 376 HOH   A O    1 
HETATM 5059 O  O    . HOH   H 4 .   ? 8.300   -1.187 24.318 1.00 33.64 ? 377 HOH   A O    1 
HETATM 5060 O  O    . HOH   H 4 .   ? -0.272  25.999 21.929 1.00 43.52 ? 378 HOH   A O    1 
HETATM 5061 O  O    . HOH   H 4 .   ? 9.902   -0.931 17.473 1.00 30.81 ? 379 HOH   A O    1 
HETATM 5062 O  O    . HOH   H 4 .   ? 2.143   2.953  26.319 1.00 24.42 ? 380 HOH   A O    1 
HETATM 5063 O  O    . HOH   H 4 .   ? 3.469   26.437 12.707 1.00 34.49 ? 381 HOH   A O    1 
HETATM 5064 O  O    . HOH   H 4 .   ? 21.650  1.869  32.077 1.00 35.25 ? 382 HOH   A O    1 
HETATM 5065 O  O    . HOH   H 4 .   ? -1.397  6.752  5.009  1.00 36.16 ? 383 HOH   A O    1 
HETATM 5066 O  O    . HOH   H 4 .   ? -7.938  13.770 -1.357 1.00 39.94 ? 384 HOH   A O    1 
HETATM 5067 O  O    . HOH   H 4 .   ? 12.403  2.466  33.345 1.00 29.52 ? 385 HOH   A O    1 
HETATM 5068 O  O    . HOH   H 4 .   ? 2.294   4.741  36.560 1.00 47.44 ? 386 HOH   A O    1 
HETATM 5069 O  O    . HOH   H 4 .   ? 25.272  11.639 20.768 1.00 45.96 ? 387 HOH   A O    1 
HETATM 5070 O  O    . HOH   H 4 .   ? 9.637   13.523 17.890 1.00 44.24 ? 388 HOH   A O    1 
HETATM 5071 O  O    . HOH   H 4 .   ? -15.820 11.547 7.616  1.00 49.32 ? 389 HOH   A O    1 
HETATM 5072 O  O    . HOH   H 4 .   ? 0.829   22.380 27.192 1.00 30.14 ? 390 HOH   A O    1 
HETATM 5073 O  O    . HOH   H 4 .   ? -1.675  11.387 50.066 1.00 39.35 ? 391 HOH   A O    1 
HETATM 5074 O  O    . HOH   H 4 .   ? -2.185  14.072 27.382 1.00 19.25 ? 392 HOH   A O    1 
HETATM 5075 O  O    . HOH   H 4 .   ? 9.354   27.348 12.046 1.00 37.24 ? 393 HOH   A O    1 
HETATM 5076 O  O    . HOH   H 4 .   ? 8.883   28.756 13.957 1.00 45.15 ? 394 HOH   A O    1 
HETATM 5077 O  O    . HOH   H 4 .   ? 8.303   8.564  42.238 1.00 31.12 ? 395 HOH   A O    1 
HETATM 5078 O  O    . HOH   H 4 .   ? -16.882 20.822 8.296  1.00 45.23 ? 396 HOH   A O    1 
HETATM 5079 O  O    . HOH   H 4 .   ? 7.005   5.049  31.868 1.00 23.66 ? 397 HOH   A O    1 
HETATM 5080 O  O    . HOH   H 4 .   ? 7.024   -2.294 13.614 1.00 20.17 ? 398 HOH   A O    1 
HETATM 5081 O  O    . HOH   H 4 .   ? 2.845   22.701 1.922  1.00 32.66 ? 399 HOH   A O    1 
HETATM 5082 O  O    . HOH   H 4 .   ? 8.160   3.063  33.594 1.00 50.59 ? 400 HOH   A O    1 
HETATM 5083 O  O    . HOH   H 4 .   ? -7.751  5.674  25.700 1.00 51.84 ? 401 HOH   A O    1 
HETATM 5084 O  O    . HOH   H 4 .   ? -3.400  1.608  14.041 1.00 37.74 ? 402 HOH   A O    1 
HETATM 5085 O  O    . HOH   H 4 .   ? -10.917 7.074  15.713 1.00 35.75 ? 403 HOH   A O    1 
HETATM 5086 O  O    . HOH   H 4 .   ? -7.616  24.197 2.551  1.00 45.19 ? 404 HOH   A O    1 
HETATM 5087 O  O    . HOH   H 4 .   ? 6.034   7.464  42.540 1.00 44.84 ? 405 HOH   A O    1 
HETATM 5088 O  O    . HOH   H 4 .   ? 6.657   4.842  40.848 1.00 54.97 ? 406 HOH   A O    1 
HETATM 5089 O  O    . HOH   H 4 .   ? 2.955   22.622 51.564 1.00 41.49 ? 407 HOH   A O    1 
HETATM 5090 O  O    . HOH   H 4 .   ? 8.009   10.716 4.509  1.00 51.10 ? 408 HOH   A O    1 
HETATM 5091 O  O    . HOH   H 4 .   ? -12.862 11.841 44.866 1.00 45.36 ? 409 HOH   A O    1 
HETATM 5092 O  O    . HOH   H 4 .   ? -4.350  3.632  12.451 1.00 47.68 ? 410 HOH   A O    1 
HETATM 5093 O  O    . HOH   H 4 .   ? -1.151  9.720  32.545 1.00 46.61 ? 411 HOH   A O    1 
HETATM 5094 O  O    . HOH   H 4 .   ? 14.934  -1.001 17.376 1.00 41.71 ? 412 HOH   A O    1 
HETATM 5095 O  O    . HOH   H 4 .   ? -10.807 6.075  24.606 1.00 51.32 ? 413 HOH   A O    1 
HETATM 5096 O  O    . HOH   H 4 .   ? 0.723   3.785  28.558 1.00 33.48 ? 414 HOH   A O    1 
HETATM 5097 O  O    . HOH   H 4 .   ? -1.300  4.997  29.078 1.00 38.53 ? 415 HOH   A O    1 
HETATM 5098 O  O    . HOH   H 4 .   ? 11.983  0.743  15.773 1.00 29.65 ? 416 HOH   A O    1 
HETATM 5099 O  O    . HOH   H 4 .   ? -0.333  6.355  31.023 1.00 33.65 ? 417 HOH   A O    1 
HETATM 5100 O  O    . HOH   H 4 .   ? 9.041   16.712 16.632 1.00 41.18 ? 418 HOH   A O    1 
HETATM 5101 O  O    . HOH   H 4 .   ? 15.943  4.142  36.396 1.00 35.80 ? 419 HOH   A O    1 
HETATM 5102 O  O    . HOH   H 4 .   ? -7.909  2.095  19.739 1.00 47.29 ? 420 HOH   A O    1 
HETATM 5103 O  O    . HOH   H 4 .   ? -5.477  5.514  24.230 1.00 44.52 ? 421 HOH   A O    1 
HETATM 5104 O  O    . HOH   H 4 .   ? -2.469  26.763 10.092 1.00 43.48 ? 422 HOH   A O    1 
HETATM 5105 O  O    . HOH   H 4 .   ? -4.734  7.390  30.159 1.00 41.63 ? 423 HOH   A O    1 
HETATM 5106 O  O    . HOH   H 4 .   ? -10.800 25.385 5.376  1.00 47.45 ? 424 HOH   A O    1 
HETATM 5107 O  O    . HOH   H 4 .   ? 15.951  -1.250 19.579 1.00 45.71 ? 425 HOH   A O    1 
HETATM 5108 O  O    . HOH   H 4 .   ? 17.259  5.161  38.644 1.00 47.78 ? 426 HOH   A O    1 
HETATM 5109 O  O    . HOH   H 4 .   ? 8.309   4.001  39.130 1.00 50.67 ? 427 HOH   A O    1 
HETATM 5110 O  O    . HOH   H 4 .   ? -4.000  5.203  28.450 1.00 40.46 ? 428 HOH   A O    1 
HETATM 5111 O  O    . HOH   H 4 .   ? 19.459  12.184 8.979  1.00 39.32 ? 429 HOH   A O    1 
HETATM 5112 O  O    . HOH   I 4 .   ? 14.261  19.990 31.598 1.00 27.23 ? 301 HOH   B O    1 
HETATM 5113 O  O    . HOH   I 4 .   ? -22.612 4.621  25.266 1.00 44.39 ? 302 HOH   B O    1 
HETATM 5114 O  O    . HOH   I 4 .   ? 25.402  22.690 32.732 1.00 44.38 ? 303 HOH   B O    1 
HETATM 5115 O  O    . HOH   I 4 .   ? 19.837  20.820 26.162 1.00 42.93 ? 304 HOH   B O    1 
HETATM 5116 O  O    . HOH   I 4 .   ? -4.222  9.483  41.225 1.00 35.55 ? 305 HOH   B O    1 
HETATM 5117 O  O    . HOH   I 4 .   ? -11.938 5.635  28.956 1.00 37.05 ? 306 HOH   B O    1 
HETATM 5118 O  O    . HOH   I 4 .   ? -21.544 30.990 32.437 1.00 34.52 ? 307 HOH   B O    1 
HETATM 5119 O  O    . HOH   I 4 .   ? -12.516 27.850 49.267 1.00 33.18 ? 308 HOH   B O    1 
HETATM 5120 O  O    . HOH   I 4 .   ? 11.308  22.973 28.444 1.00 35.58 ? 309 HOH   B O    1 
HETATM 5121 O  O    . HOH   I 4 .   ? -14.172 11.020 27.082 1.00 14.00 ? 310 HOH   B O    1 
HETATM 5122 O  O    . HOH   I 4 .   ? -5.791  20.358 37.167 1.00 17.02 ? 311 HOH   B O    1 
HETATM 5123 O  O    . HOH   I 4 .   ? 3.668   23.666 49.277 1.00 27.78 ? 312 HOH   B O    1 
HETATM 5124 O  O    . HOH   I 4 .   ? -14.088 19.709 34.176 1.00 21.72 ? 313 HOH   B O    1 
HETATM 5125 O  O    . HOH   I 4 .   ? -7.402  27.198 22.744 1.00 24.21 ? 314 HOH   B O    1 
HETATM 5126 O  O    . HOH   I 4 .   ? -13.156 20.202 39.710 1.00 26.49 ? 315 HOH   B O    1 
HETATM 5127 O  O    . HOH   I 4 .   ? -24.781 23.071 17.881 1.00 34.89 ? 316 HOH   B O    1 
HETATM 5128 O  O    . HOH   I 4 .   ? 0.340   27.465 46.886 1.00 24.05 ? 317 HOH   B O    1 
HETATM 5129 O  O    . HOH   I 4 .   ? -1.127  21.553 30.614 1.00 21.05 ? 318 HOH   B O    1 
HETATM 5130 O  O    . HOH   I 4 .   ? -14.210 14.056 44.563 1.00 33.68 ? 319 HOH   B O    1 
HETATM 5131 O  O    . HOH   I 4 .   ? 7.270   24.785 42.383 1.00 26.26 ? 320 HOH   B O    1 
HETATM 5132 O  O    . HOH   I 4 .   ? -13.237 6.579  25.990 1.00 30.46 ? 321 HOH   B O    1 
HETATM 5133 O  O    . HOH   I 4 .   ? -12.359 35.472 40.861 1.00 35.70 ? 322 HOH   B O    1 
HETATM 5134 O  O    . HOH   I 4 .   ? 1.585   5.505  41.024 1.00 42.25 ? 323 HOH   B O    1 
HETATM 5135 O  O    . HOH   I 4 .   ? 3.449   17.891 48.507 1.00 28.99 ? 324 HOH   B O    1 
HETATM 5136 O  O    . HOH   I 4 .   ? -22.415 19.359 39.500 1.00 21.08 ? 325 HOH   B O    1 
HETATM 5137 O  O    . HOH   I 4 .   ? -30.457 16.497 32.928 1.00 27.52 ? 326 HOH   B O    1 
HETATM 5138 O  O    . HOH   I 4 .   ? -17.273 23.967 33.724 1.00 16.33 ? 327 HOH   B O    1 
HETATM 5139 O  O    . HOH   I 4 .   ? 15.508  21.933 26.245 1.00 44.36 ? 328 HOH   B O    1 
HETATM 5140 O  O    . HOH   I 4 .   ? -10.564 28.399 41.217 1.00 16.43 ? 329 HOH   B O    1 
HETATM 5141 O  O    . HOH   I 4 .   ? -20.167 7.798  22.900 1.00 30.11 ? 330 HOH   B O    1 
HETATM 5142 O  O    . HOH   I 4 .   ? 3.398   10.352 42.928 1.00 39.21 ? 331 HOH   B O    1 
HETATM 5143 O  O    . HOH   I 4 .   ? -21.408 7.421  17.961 1.00 28.61 ? 332 HOH   B O    1 
HETATM 5144 O  O    . HOH   I 4 .   ? -3.680  25.504 47.664 1.00 18.36 ? 333 HOH   B O    1 
HETATM 5145 O  O    . HOH   I 4 .   ? -18.650 15.302 16.820 1.00 17.01 ? 334 HOH   B O    1 
HETATM 5146 O  O    . HOH   I 4 .   ? -8.189  33.867 41.971 1.00 42.87 ? 335 HOH   B O    1 
HETATM 5147 O  O    . HOH   I 4 .   ? -17.693 12.250 44.395 1.00 36.67 ? 336 HOH   B O    1 
HETATM 5148 O  O    . HOH   I 4 .   ? -1.617  28.097 26.280 1.00 40.23 ? 337 HOH   B O    1 
HETATM 5149 O  O    . HOH   I 4 .   ? -19.228 20.967 38.666 1.00 31.62 ? 338 HOH   B O    1 
HETATM 5150 O  O    . HOH   I 4 .   ? -23.887 19.499 43.623 1.00 31.70 ? 339 HOH   B O    1 
HETATM 5151 O  O    . HOH   I 4 .   ? 5.814   27.561 42.974 1.00 43.00 ? 340 HOH   B O    1 
HETATM 5152 O  O    . HOH   I 4 .   ? -25.335 24.026 35.515 1.00 32.38 ? 341 HOH   B O    1 
HETATM 5153 O  O    . HOH   I 4 .   ? -6.604  31.727 31.243 1.00 24.17 ? 342 HOH   B O    1 
HETATM 5154 O  O    . HOH   I 4 .   ? -5.331  26.204 50.682 1.00 32.78 ? 343 HOH   B O    1 
HETATM 5155 O  O    . HOH   I 4 .   ? -2.515  10.176 35.530 1.00 25.72 ? 344 HOH   B O    1 
HETATM 5156 O  O    . HOH   I 4 .   ? -5.204  24.261 54.589 1.00 41.19 ? 345 HOH   B O    1 
HETATM 5157 O  O    . HOH   I 4 .   ? -1.371  20.633 28.118 1.00 22.32 ? 346 HOH   B O    1 
HETATM 5158 O  O    . HOH   I 4 .   ? -22.915 28.383 26.378 1.00 37.40 ? 347 HOH   B O    1 
HETATM 5159 O  O    . HOH   I 4 .   ? -18.521 24.005 48.416 1.00 36.99 ? 348 HOH   B O    1 
HETATM 5160 O  O    . HOH   I 4 .   ? -31.646 13.954 32.774 1.00 28.01 ? 349 HOH   B O    1 
HETATM 5161 O  O    . HOH   I 4 .   ? -16.231 29.489 39.024 1.00 19.15 ? 350 HOH   B O    1 
HETATM 5162 O  O    . HOH   I 4 .   ? -22.549 7.998  41.485 1.00 34.20 ? 351 HOH   B O    1 
HETATM 5163 O  O    . HOH   I 4 .   ? -15.449 5.918  31.470 1.00 38.76 ? 352 HOH   B O    1 
HETATM 5164 O  O    . HOH   I 4 .   ? -17.193 16.624 35.409 1.00 30.36 ? 353 HOH   B O    1 
HETATM 5165 O  O    . HOH   I 4 .   ? -6.683  35.912 36.598 1.00 24.02 ? 354 HOH   B O    1 
HETATM 5166 O  O    . HOH   I 4 .   ? -8.963  33.931 39.508 1.00 39.26 ? 355 HOH   B O    1 
HETATM 5167 O  O    . HOH   I 4 .   ? -30.317 20.755 21.428 1.00 33.53 ? 356 HOH   B O    1 
HETATM 5168 O  O    . HOH   I 4 .   ? -15.115 26.622 19.548 1.00 28.34 ? 357 HOH   B O    1 
HETATM 5169 O  O    . HOH   I 4 .   ? 0.177   31.163 32.360 1.00 47.96 ? 358 HOH   B O    1 
HETATM 5170 O  O    . HOH   I 4 .   ? -19.691 17.895 36.314 1.00 26.11 ? 359 HOH   B O    1 
HETATM 5171 O  O    . HOH   I 4 .   ? -13.741 16.572 35.645 1.00 35.12 ? 360 HOH   B O    1 
HETATM 5172 O  O    . HOH   I 4 .   ? -26.257 11.921 21.698 1.00 30.74 ? 361 HOH   B O    1 
HETATM 5173 O  O    . HOH   I 4 .   ? -4.615  33.978 36.366 1.00 31.15 ? 362 HOH   B O    1 
HETATM 5174 O  O    . HOH   I 4 .   ? -5.174  32.845 45.147 1.00 45.76 ? 363 HOH   B O    1 
HETATM 5175 O  O    . HOH   I 4 .   ? -30.289 18.615 17.288 1.00 39.40 ? 364 HOH   B O    1 
HETATM 5176 O  O    . HOH   I 4 .   ? -16.827 22.409 38.985 1.00 26.85 ? 365 HOH   B O    1 
HETATM 5177 O  O    . HOH   I 4 .   ? -20.103 18.007 38.789 1.00 33.04 ? 366 HOH   B O    1 
HETATM 5178 O  O    . HOH   I 4 .   ? -4.723  29.951 32.245 1.00 19.31 ? 367 HOH   B O    1 
HETATM 5179 O  O    . HOH   I 4 .   ? -15.723 29.111 31.732 1.00 30.88 ? 368 HOH   B O    1 
HETATM 5180 O  O    . HOH   I 4 .   ? 8.102   20.272 47.328 1.00 29.50 ? 369 HOH   B O    1 
HETATM 5181 O  O    . HOH   I 4 .   ? -15.447 6.867  17.261 1.00 39.05 ? 370 HOH   B O    1 
HETATM 5182 O  O    . HOH   I 4 .   ? -22.259 29.548 34.589 1.00 24.83 ? 371 HOH   B O    1 
HETATM 5183 O  O    . HOH   I 4 .   ? -18.263 8.314  21.185 1.00 31.61 ? 372 HOH   B O    1 
HETATM 5184 O  O    . HOH   I 4 .   ? -3.811  9.629  31.018 1.00 32.87 ? 373 HOH   B O    1 
HETATM 5185 O  O    . HOH   I 4 .   ? 0.334   29.932 43.493 1.00 30.84 ? 374 HOH   B O    1 
HETATM 5186 O  O    . HOH   I 4 .   ? 21.565  15.327 30.084 1.00 33.40 ? 375 HOH   B O    1 
HETATM 5187 O  O    . HOH   I 4 .   ? 12.094  22.789 38.136 1.00 45.06 ? 376 HOH   B O    1 
HETATM 5188 O  O    . HOH   I 4 .   ? -15.650 26.474 36.110 1.00 21.67 ? 377 HOH   B O    1 
HETATM 5189 O  O    . HOH   I 4 .   ? -10.329 7.041  40.082 1.00 31.95 ? 378 HOH   B O    1 
HETATM 5190 O  O    . HOH   I 4 .   ? 15.473  18.448 39.699 1.00 46.10 ? 379 HOH   B O    1 
HETATM 5191 O  O    . HOH   I 4 .   ? -26.251 7.796  21.704 1.00 34.62 ? 380 HOH   B O    1 
HETATM 5192 O  O    . HOH   I 4 .   ? -0.164  27.565 37.837 1.00 24.18 ? 381 HOH   B O    1 
HETATM 5193 O  O    . HOH   I 4 .   ? -28.856 7.659  31.999 1.00 30.72 ? 382 HOH   B O    1 
HETATM 5194 O  O    . HOH   I 4 .   ? -13.458 31.058 25.269 1.00 25.25 ? 383 HOH   B O    1 
HETATM 5195 O  O    . HOH   I 4 .   ? -26.905 22.004 34.161 1.00 49.74 ? 384 HOH   B O    1 
HETATM 5196 O  O    . HOH   I 4 .   ? 19.378  21.053 32.457 1.00 38.07 ? 385 HOH   B O    1 
HETATM 5197 O  O    . HOH   I 4 .   ? -11.979 30.264 49.063 1.00 43.57 ? 386 HOH   B O    1 
HETATM 5198 O  O    . HOH   I 4 .   ? -2.449  30.607 52.343 1.00 37.57 ? 387 HOH   B O    1 
HETATM 5199 O  O    . HOH   I 4 .   ? -9.350  6.426  28.887 1.00 31.78 ? 388 HOH   B O    1 
HETATM 5200 O  O    . HOH   I 4 .   ? 2.541   22.497 29.918 1.00 33.52 ? 389 HOH   B O    1 
HETATM 5201 O  O    . HOH   I 4 .   ? 10.494  24.790 38.905 1.00 49.12 ? 390 HOH   B O    1 
HETATM 5202 O  O    . HOH   I 4 .   ? 5.494   28.098 34.662 1.00 50.19 ? 391 HOH   B O    1 
HETATM 5203 O  O    . HOH   I 4 .   ? -23.385 30.690 38.668 1.00 45.58 ? 392 HOH   B O    1 
HETATM 5204 O  O    . HOH   I 4 .   ? -2.843  18.495 28.000 1.00 17.20 ? 393 HOH   B O    1 
HETATM 5205 O  O    . HOH   I 4 .   ? -15.007 23.904 36.892 1.00 27.61 ? 394 HOH   B O    1 
HETATM 5206 O  O    . HOH   I 4 .   ? -21.588 12.111 10.967 1.00 41.70 ? 395 HOH   B O    1 
HETATM 5207 O  O    . HOH   I 4 .   ? -18.257 6.020  30.825 1.00 34.90 ? 396 HOH   B O    1 
HETATM 5208 O  O    . HOH   I 4 .   ? -17.105 28.740 23.470 1.00 38.48 ? 397 HOH   B O    1 
HETATM 5209 O  O    . HOH   I 4 .   ? -22.293 32.332 40.790 1.00 39.19 ? 398 HOH   B O    1 
HETATM 5210 O  O    . HOH   I 4 .   ? 9.773   24.054 40.902 1.00 30.23 ? 399 HOH   B O    1 
HETATM 5211 O  O    . HOH   I 4 .   ? -0.767  25.863 54.108 1.00 42.78 ? 400 HOH   B O    1 
HETATM 5212 O  O    . HOH   I 4 .   ? -15.898 30.603 24.249 1.00 41.23 ? 401 HOH   B O    1 
HETATM 5213 O  O    . HOH   I 4 .   ? -14.232 19.182 38.195 1.00 39.05 ? 402 HOH   B O    1 
HETATM 5214 O  O    . HOH   I 4 .   ? -1.543  16.254 28.885 1.00 18.98 ? 403 HOH   B O    1 
HETATM 5215 O  O    . HOH   I 4 .   ? 0.425   26.164 30.657 1.00 41.75 ? 404 HOH   B O    1 
HETATM 5216 O  O    . HOH   I 4 .   ? -12.568 6.420  12.144 1.00 45.69 ? 405 HOH   B O    1 
HETATM 5217 O  O    . HOH   I 4 .   ? -16.055 26.601 15.400 1.00 46.01 ? 406 HOH   B O    1 
HETATM 5218 O  O    . HOH   I 4 .   ? -22.206 32.067 36.129 1.00 42.24 ? 407 HOH   B O    1 
HETATM 5219 O  O    . HOH   I 4 .   ? -11.908 26.483 17.637 1.00 38.40 ? 408 HOH   B O    1 
HETATM 5220 O  O    . HOH   I 4 .   ? -16.136 16.419 37.347 1.00 43.58 ? 409 HOH   B O    1 
HETATM 5221 O  O    . HOH   I 4 .   ? -10.730 31.113 21.605 1.00 52.68 ? 410 HOH   B O    1 
HETATM 5222 O  O    . HOH   I 4 .   ? 1.226   31.060 45.715 1.00 47.29 ? 411 HOH   B O    1 
HETATM 5223 O  O    . HOH   I 4 .   ? -23.345 29.935 27.946 1.00 51.84 ? 412 HOH   B O    1 
HETATM 5224 O  O    . HOH   I 4 .   ? -2.934  33.734 46.085 1.00 49.95 ? 413 HOH   B O    1 
HETATM 5225 O  O    . HOH   I 4 .   ? -30.004 20.958 18.816 1.00 46.04 ? 414 HOH   B O    1 
HETATM 5226 O  O    . HOH   I 4 .   ? -27.718 4.087  34.494 1.00 45.21 ? 415 HOH   B O    1 
HETATM 5227 O  O    . HOH   I 4 .   ? 13.789  24.324 24.969 1.00 40.51 ? 416 HOH   B O    1 
HETATM 5228 O  O    . HOH   I 4 .   ? -24.332 27.876 33.366 1.00 36.30 ? 417 HOH   B O    1 
HETATM 5229 O  O    . HOH   I 4 .   ? -14.664 4.509  18.807 1.00 48.90 ? 418 HOH   B O    1 
HETATM 5230 O  O    . HOH   I 4 .   ? -5.226  27.364 24.190 1.00 48.60 ? 419 HOH   B O    1 
HETATM 5231 O  O    . HOH   I 4 .   ? -17.869 5.379  26.876 1.00 53.26 ? 420 HOH   B O    1 
HETATM 5232 O  O    . HOH   I 4 .   ? -20.085 5.895  24.759 1.00 44.13 ? 421 HOH   B O    1 
HETATM 5233 O  O    . HOH   I 4 .   ? -18.777 33.408 38.041 1.00 33.92 ? 422 HOH   B O    1 
HETATM 5234 O  O    . HOH   I 4 .   ? -23.706 22.867 15.486 1.00 41.51 ? 423 HOH   B O    1 
HETATM 5235 O  O    . HOH   I 4 .   ? -13.256 7.225  16.575 1.00 46.14 ? 424 HOH   B O    1 
HETATM 5236 O  O    . HOH   I 4 .   ? -24.956 20.096 45.792 1.00 41.16 ? 425 HOH   B O    1 
HETATM 5237 O  O    . HOH   I 4 .   ? -21.221 24.311 47.773 1.00 41.77 ? 426 HOH   B O    1 
HETATM 5238 O  O    . HOH   I 4 .   ? -33.411 3.395  38.553 1.00 52.54 ? 427 HOH   B O    1 
HETATM 5239 O  O    . HOH   I 4 .   ? -16.148 9.804  43.962 1.00 43.17 ? 428 HOH   B O    1 
# 
