data_9F8K
# 
_entry.id   9F8K 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9F8K         pdb_00009f8k 10.2210/pdb9f8k/pdb 
WWPDB D_1292138234 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-16 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9F8K 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-06 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB 'Contains the same protein complexed with different ligand' 9F8H unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8I unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8J unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8L unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8M unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8N unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8O unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8P unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8R unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8S unspecified 
PDB 'Contains the same protein complexed with different ligand' 9F8Q unspecified 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 wulf.blankenfeldt@helmholtz-hzi.de Wulf   Blankenfeldt ? 'principal investigator/group leader' 0000-0001-9886-9668 
4 c.kunick@tu-braunschweig.de        Conrad Kunick       ? 'principal investigator/group leader' 0000-0001-7041-5322 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Thiemann, M.'     1 0009-0009-1111-0671 
'Zimmermann, M.'   2 0009-0005-8293-7255 
'Kunick, C.'       3 0000-0001-7041-5322 
'Blankenfeldt, W.' 4 0000-0001-9886-9668 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Med.Chem. 
_citation.journal_id_ASTM           JMCMAR 
_citation.journal_id_CSD            0151 
_citation.journal_id_ISSN           0022-2623 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            68 
_citation.language                  ? 
_citation.page_first                7390 
_citation.page_last                 7420 
_citation.title                     
;From Bones to Bugs: Structure-Based Development of Raloxifene-Derived Pathoblockers That Inhibit Pyocyanin Production in Pseudomonas aeruginosa.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.jmedchem.4c03065 
_citation.pdbx_database_id_PubMed   40156840 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Thiemann, M.'        1  0009-0009-1111-0671 
primary 'Zimmermann, M.'      2  0009-0005-8293-7255 
primary 'Diederich, C.'       3  ?                   
primary 'Zhan, H.'            4  0009-0002-7304-9174 
primary 'Lebedev, M.'         5  0000-0001-7461-0977 
primary 'Pletz, J.'           6  ?                   
primary 'Baumgarten, J.'      7  0009-0003-6748-6316 
primary 'Handke, M.'          8  0009-0007-7175-3615 
primary 'Musken, M.'          9  ?                   
primary 'Breinbauer, R.'      10 0000-0001-6009-7359 
primary 'Krasteva-Christ, G.' 11 0000-0002-0113-521X 
primary 'Zanin, E.'           12 ?                   
primary 'Empting, M.'         13 ?                   
primary 'Schiedel, M.'        14 0000-0001-7365-3617 
primary 'Kunick, C.'          15 ?                   
primary 'Blankenfeldt, W.'    16 0000-0001-9886-9668 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Phenazine biosynthesis protein A/B'                                                   21531.025 2   ? ? ? ? 
2 non-polymer syn GLYCEROL                                                                               92.094    4   ? ? ? ? 
3 non-polymer syn 'ACETATE ION'                                                                          59.044    1   ? ? ? ? 
4 non-polymer syn '[2-(4-hydroxyphenyl)-6-oxidanyl-1-benzothiophen-3-yl]-(3-propan-2-ylphenyl)methanone' 388.479   1   ? ? ? ? 
5 water       nat water                                                                                  18.015    374 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGLVPRGSHMSDVESLENTSENRAQVAARQHNRKIVEQYMHTRGEARLKRHLLFTEDGVGGLWTTDSGQ
PIAIRGREKLGEHAVWSLQCFPDWVWTDIQIFETQDPNWFWVECRGEGAIVFPGYPRGQYRNHFLHSFRFENGLIKEQRE
FMNPCEQFRSLGIEVPEVRRDGLPS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGLVPRGSHMSDVESLENTSENRAQVAARQHNRKIVEQYMHTRGEARLKRHLLFTEDGVGGLWTTDSGQ
PIAIRGREKLGEHAVWSLQCFPDWVWTDIQIFETQDPNWFWVECRGEGAIVFPGYPRGQYRNHFLHSFRFENGLIKEQRE
FMNPCEQFRSLGIEVPEVRRDGLPS
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 GLYCEROL                                                                               GOL   
3 'ACETATE ION'                                                                          ACT   
4 '[2-(4-hydroxyphenyl)-6-oxidanyl-1-benzothiophen-3-yl]-(3-propan-2-ylphenyl)methanone' A1IAH 
5 water                                                                                  HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  ARG n 
1 18  GLY n 
1 19  SER n 
1 20  HIS n 
1 21  MET n 
1 22  SER n 
1 23  ASP n 
1 24  VAL n 
1 25  GLU n 
1 26  SER n 
1 27  LEU n 
1 28  GLU n 
1 29  ASN n 
1 30  THR n 
1 31  SER n 
1 32  GLU n 
1 33  ASN n 
1 34  ARG n 
1 35  ALA n 
1 36  GLN n 
1 37  VAL n 
1 38  ALA n 
1 39  ALA n 
1 40  ARG n 
1 41  GLN n 
1 42  HIS n 
1 43  ASN n 
1 44  ARG n 
1 45  LYS n 
1 46  ILE n 
1 47  VAL n 
1 48  GLU n 
1 49  GLN n 
1 50  TYR n 
1 51  MET n 
1 52  HIS n 
1 53  THR n 
1 54  ARG n 
1 55  GLY n 
1 56  GLU n 
1 57  ALA n 
1 58  ARG n 
1 59  LEU n 
1 60  LYS n 
1 61  ARG n 
1 62  HIS n 
1 63  LEU n 
1 64  LEU n 
1 65  PHE n 
1 66  THR n 
1 67  GLU n 
1 68  ASP n 
1 69  GLY n 
1 70  VAL n 
1 71  GLY n 
1 72  GLY n 
1 73  LEU n 
1 74  TRP n 
1 75  THR n 
1 76  THR n 
1 77  ASP n 
1 78  SER n 
1 79  GLY n 
1 80  GLN n 
1 81  PRO n 
1 82  ILE n 
1 83  ALA n 
1 84  ILE n 
1 85  ARG n 
1 86  GLY n 
1 87  ARG n 
1 88  GLU n 
1 89  LYS n 
1 90  LEU n 
1 91  GLY n 
1 92  GLU n 
1 93  HIS n 
1 94  ALA n 
1 95  VAL n 
1 96  TRP n 
1 97  SER n 
1 98  LEU n 
1 99  GLN n 
1 100 CYS n 
1 101 PHE n 
1 102 PRO n 
1 103 ASP n 
1 104 TRP n 
1 105 VAL n 
1 106 TRP n 
1 107 THR n 
1 108 ASP n 
1 109 ILE n 
1 110 GLN n 
1 111 ILE n 
1 112 PHE n 
1 113 GLU n 
1 114 THR n 
1 115 GLN n 
1 116 ASP n 
1 117 PRO n 
1 118 ASN n 
1 119 TRP n 
1 120 PHE n 
1 121 TRP n 
1 122 VAL n 
1 123 GLU n 
1 124 CYS n 
1 125 ARG n 
1 126 GLY n 
1 127 GLU n 
1 128 GLY n 
1 129 ALA n 
1 130 ILE n 
1 131 VAL n 
1 132 PHE n 
1 133 PRO n 
1 134 GLY n 
1 135 TYR n 
1 136 PRO n 
1 137 ARG n 
1 138 GLY n 
1 139 GLN n 
1 140 TYR n 
1 141 ARG n 
1 142 ASN n 
1 143 HIS n 
1 144 PHE n 
1 145 LEU n 
1 146 HIS n 
1 147 SER n 
1 148 PHE n 
1 149 ARG n 
1 150 PHE n 
1 151 GLU n 
1 152 ASN n 
1 153 GLY n 
1 154 LEU n 
1 155 ILE n 
1 156 LYS n 
1 157 GLU n 
1 158 GLN n 
1 159 ARG n 
1 160 GLU n 
1 161 PHE n 
1 162 MET n 
1 163 ASN n 
1 164 PRO n 
1 165 CYS n 
1 166 GLU n 
1 167 GLN n 
1 168 PHE n 
1 169 ARG n 
1 170 SER n 
1 171 LEU n 
1 172 GLY n 
1 173 ILE n 
1 174 GLU n 
1 175 VAL n 
1 176 PRO n 
1 177 GLU n 
1 178 VAL n 
1 179 ARG n 
1 180 ARG n 
1 181 ASP n 
1 182 GLY n 
1 183 LEU n 
1 184 PRO n 
1 185 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   185 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 Bcep18194_B1568 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Burkholderia lata' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     482957 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pET15b 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1IAH non-polymer         . '[2-(4-hydroxyphenyl)-6-oxidanyl-1-benzothiophen-3-yl]-(3-propan-2-ylphenyl)methanone' 
'[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl](3-isopropylphenyl)methanone' 'C24 H20 O3 S'   388.479 
ACT   non-polymer         . 'ACETATE ION'                                                                          ? 'C2 H3 O2 -1' 
59.044  
ALA   'L-peptide linking' y ALANINE                                                                                ? 'C3 H7 N O2' 
89.093  
ARG   'L-peptide linking' y ARGININE                                                                               ? 
'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                                             ? 'C4 H8 N2 O3' 
132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                                        ? 'C4 H7 N O4' 
133.103 
CYS   'L-peptide linking' y CYSTEINE                                                                               ? 
'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE                                                                              ? 
'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                                        ? 'C5 H9 N O4' 
147.129 
GLY   'peptide linking'   y GLYCINE                                                                                ? 'C2 H5 N O2' 
75.067  
GOL   non-polymer         . GLYCEROL                                                                               
'GLYCERIN; PROPANE-1,2,3-TRIOL'                                                    'C3 H8 O3'       92.094  
HIS   'L-peptide linking' y HISTIDINE                                                                              ? 
'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER                                                                                  ? 'H2 O' 18.015 
ILE   'L-peptide linking' y ISOLEUCINE                                                                             ? 'C6 H13 N O2' 
131.173 
LEU   'L-peptide linking' y LEUCINE                                                                                ? 'C6 H13 N O2' 
131.173 
LYS   'L-peptide linking' y LYSINE                                                                                 ? 
'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE                                                                             ? 
'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE                                                                          ? 'C9 H11 N O2' 
165.189 
PRO   'L-peptide linking' y PROLINE                                                                                ? 'C5 H9 N O2' 
115.130 
SER   'L-peptide linking' y SERINE                                                                                 ? 'C3 H7 N O3' 
105.093 
THR   'L-peptide linking' y THREONINE                                                                              ? 'C4 H9 N O3' 
119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                                                             ? 
'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE                                                                               ? 'C9 H11 N O3' 
181.189 
VAL   'L-peptide linking' y VALINE                                                                                 ? 'C5 H11 N O2' 
117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -19 ?   ?   ?   A . n 
A 1 2   GLY 2   -18 ?   ?   ?   A . n 
A 1 3   SER 3   -17 ?   ?   ?   A . n 
A 1 4   SER 4   -16 ?   ?   ?   A . n 
A 1 5   HIS 5   -15 ?   ?   ?   A . n 
A 1 6   HIS 6   -14 ?   ?   ?   A . n 
A 1 7   HIS 7   -13 ?   ?   ?   A . n 
A 1 8   HIS 8   -12 ?   ?   ?   A . n 
A 1 9   HIS 9   -11 ?   ?   ?   A . n 
A 1 10  HIS 10  -10 ?   ?   ?   A . n 
A 1 11  SER 11  -9  ?   ?   ?   A . n 
A 1 12  SER 12  -8  ?   ?   ?   A . n 
A 1 13  GLY 13  -7  ?   ?   ?   A . n 
A 1 14  LEU 14  -6  ?   ?   ?   A . n 
A 1 15  VAL 15  -5  ?   ?   ?   A . n 
A 1 16  PRO 16  -4  ?   ?   ?   A . n 
A 1 17  ARG 17  -3  ?   ?   ?   A . n 
A 1 18  GLY 18  -2  ?   ?   ?   A . n 
A 1 19  SER 19  -1  ?   ?   ?   A . n 
A 1 20  HIS 20  0   ?   ?   ?   A . n 
A 1 21  MET 21  1   ?   ?   ?   A . n 
A 1 22  SER 22  2   ?   ?   ?   A . n 
A 1 23  ASP 23  3   ?   ?   ?   A . n 
A 1 24  VAL 24  4   ?   ?   ?   A . n 
A 1 25  GLU 25  5   ?   ?   ?   A . n 
A 1 26  SER 26  6   ?   ?   ?   A . n 
A 1 27  LEU 27  7   ?   ?   ?   A . n 
A 1 28  GLU 28  8   ?   ?   ?   A . n 
A 1 29  ASN 29  9   ?   ?   ?   A . n 
A 1 30  THR 30  10  ?   ?   ?   A . n 
A 1 31  SER 31  11  ?   ?   ?   A . n 
A 1 32  GLU 32  12  12  GLU GLU A . n 
A 1 33  ASN 33  13  13  ASN ASN A . n 
A 1 34  ARG 34  14  14  ARG ARG A . n 
A 1 35  ALA 35  15  15  ALA ALA A . n 
A 1 36  GLN 36  16  16  GLN GLN A . n 
A 1 37  VAL 37  17  17  VAL VAL A . n 
A 1 38  ALA 38  18  18  ALA ALA A . n 
A 1 39  ALA 39  19  19  ALA ALA A . n 
A 1 40  ARG 40  20  20  ARG ARG A . n 
A 1 41  GLN 41  21  21  GLN GLN A . n 
A 1 42  HIS 42  22  22  HIS HIS A . n 
A 1 43  ASN 43  23  23  ASN ASN A . n 
A 1 44  ARG 44  24  24  ARG ARG A . n 
A 1 45  LYS 45  25  25  LYS LYS A . n 
A 1 46  ILE 46  26  26  ILE ILE A . n 
A 1 47  VAL 47  27  27  VAL VAL A . n 
A 1 48  GLU 48  28  28  GLU GLU A . n 
A 1 49  GLN 49  29  29  GLN GLN A . n 
A 1 50  TYR 50  30  30  TYR TYR A . n 
A 1 51  MET 51  31  31  MET MET A . n 
A 1 52  HIS 52  32  32  HIS HIS A . n 
A 1 53  THR 53  33  33  THR THR A . n 
A 1 54  ARG 54  34  34  ARG ARG A . n 
A 1 55  GLY 55  35  35  GLY GLY A . n 
A 1 56  GLU 56  36  36  GLU GLU A . n 
A 1 57  ALA 57  37  37  ALA ALA A . n 
A 1 58  ARG 58  38  38  ARG ARG A . n 
A 1 59  LEU 59  39  39  LEU LEU A . n 
A 1 60  LYS 60  40  40  LYS LYS A . n 
A 1 61  ARG 61  41  41  ARG ARG A . n 
A 1 62  HIS 62  42  42  HIS HIS A . n 
A 1 63  LEU 63  43  43  LEU LEU A . n 
A 1 64  LEU 64  44  44  LEU LEU A . n 
A 1 65  PHE 65  45  45  PHE PHE A . n 
A 1 66  THR 66  46  46  THR THR A . n 
A 1 67  GLU 67  47  47  GLU GLU A . n 
A 1 68  ASP 68  48  48  ASP ASP A . n 
A 1 69  GLY 69  49  49  GLY GLY A . n 
A 1 70  VAL 70  50  50  VAL VAL A . n 
A 1 71  GLY 71  51  51  GLY GLY A . n 
A 1 72  GLY 72  52  52  GLY GLY A . n 
A 1 73  LEU 73  53  53  LEU LEU A . n 
A 1 74  TRP 74  54  54  TRP TRP A . n 
A 1 75  THR 75  55  55  THR THR A . n 
A 1 76  THR 76  56  56  THR THR A . n 
A 1 77  ASP 77  57  57  ASP ASP A . n 
A 1 78  SER 78  58  58  SER SER A . n 
A 1 79  GLY 79  59  59  GLY GLY A . n 
A 1 80  GLN 80  60  60  GLN GLN A . n 
A 1 81  PRO 81  61  61  PRO PRO A . n 
A 1 82  ILE 82  62  62  ILE ILE A . n 
A 1 83  ALA 83  63  63  ALA ALA A . n 
A 1 84  ILE 84  64  64  ILE ILE A . n 
A 1 85  ARG 85  65  65  ARG ARG A . n 
A 1 86  GLY 86  66  66  GLY GLY A . n 
A 1 87  ARG 87  67  67  ARG ARG A . n 
A 1 88  GLU 88  68  68  GLU GLU A . n 
A 1 89  LYS 89  69  69  LYS LYS A . n 
A 1 90  LEU 90  70  70  LEU LEU A . n 
A 1 91  GLY 91  71  71  GLY GLY A . n 
A 1 92  GLU 92  72  72  GLU GLU A . n 
A 1 93  HIS 93  73  73  HIS HIS A . n 
A 1 94  ALA 94  74  74  ALA ALA A . n 
A 1 95  VAL 95  75  75  VAL VAL A . n 
A 1 96  TRP 96  76  76  TRP TRP A . n 
A 1 97  SER 97  77  77  SER SER A . n 
A 1 98  LEU 98  78  78  LEU LEU A . n 
A 1 99  GLN 99  79  79  GLN GLN A . n 
A 1 100 CYS 100 80  80  CYS CYS A . n 
A 1 101 PHE 101 81  81  PHE PHE A . n 
A 1 102 PRO 102 82  82  PRO PRO A . n 
A 1 103 ASP 103 83  83  ASP ASP A . n 
A 1 104 TRP 104 84  84  TRP TRP A . n 
A 1 105 VAL 105 85  85  VAL VAL A . n 
A 1 106 TRP 106 86  86  TRP TRP A . n 
A 1 107 THR 107 87  87  THR THR A . n 
A 1 108 ASP 108 88  88  ASP ASP A . n 
A 1 109 ILE 109 89  89  ILE ILE A . n 
A 1 110 GLN 110 90  90  GLN GLN A . n 
A 1 111 ILE 111 91  91  ILE ILE A . n 
A 1 112 PHE 112 92  92  PHE PHE A . n 
A 1 113 GLU 113 93  93  GLU GLU A . n 
A 1 114 THR 114 94  94  THR THR A . n 
A 1 115 GLN 115 95  95  GLN GLN A . n 
A 1 116 ASP 116 96  96  ASP ASP A . n 
A 1 117 PRO 117 97  97  PRO PRO A . n 
A 1 118 ASN 118 98  98  ASN ASN A . n 
A 1 119 TRP 119 99  99  TRP TRP A . n 
A 1 120 PHE 120 100 100 PHE PHE A . n 
A 1 121 TRP 121 101 101 TRP TRP A . n 
A 1 122 VAL 122 102 102 VAL VAL A . n 
A 1 123 GLU 123 103 103 GLU GLU A . n 
A 1 124 CYS 124 104 104 CYS CYS A . n 
A 1 125 ARG 125 105 105 ARG ARG A . n 
A 1 126 GLY 126 106 106 GLY GLY A . n 
A 1 127 GLU 127 107 107 GLU GLU A . n 
A 1 128 GLY 128 108 108 GLY GLY A . n 
A 1 129 ALA 129 109 109 ALA ALA A . n 
A 1 130 ILE 130 110 110 ILE ILE A . n 
A 1 131 VAL 131 111 111 VAL VAL A . n 
A 1 132 PHE 132 112 112 PHE PHE A . n 
A 1 133 PRO 133 113 113 PRO PRO A . n 
A 1 134 GLY 134 114 114 GLY GLY A . n 
A 1 135 TYR 135 115 115 TYR TYR A . n 
A 1 136 PRO 136 116 116 PRO PRO A . n 
A 1 137 ARG 137 117 117 ARG ARG A . n 
A 1 138 GLY 138 118 118 GLY GLY A . n 
A 1 139 GLN 139 119 119 GLN GLN A . n 
A 1 140 TYR 140 120 120 TYR TYR A . n 
A 1 141 ARG 141 121 121 ARG ARG A . n 
A 1 142 ASN 142 122 122 ASN ASN A . n 
A 1 143 HIS 143 123 123 HIS HIS A . n 
A 1 144 PHE 144 124 124 PHE PHE A . n 
A 1 145 LEU 145 125 125 LEU LEU A . n 
A 1 146 HIS 146 126 126 HIS HIS A . n 
A 1 147 SER 147 127 127 SER SER A . n 
A 1 148 PHE 148 128 128 PHE PHE A . n 
A 1 149 ARG 149 129 129 ARG ARG A . n 
A 1 150 PHE 150 130 130 PHE PHE A . n 
A 1 151 GLU 151 131 131 GLU GLU A . n 
A 1 152 ASN 152 132 132 ASN ASN A . n 
A 1 153 GLY 153 133 133 GLY GLY A . n 
A 1 154 LEU 154 134 134 LEU LEU A . n 
A 1 155 ILE 155 135 135 ILE ILE A . n 
A 1 156 LYS 156 136 136 LYS LYS A . n 
A 1 157 GLU 157 137 137 GLU GLU A . n 
A 1 158 GLN 158 138 138 GLN GLN A . n 
A 1 159 ARG 159 139 139 ARG ARG A . n 
A 1 160 GLU 160 140 140 GLU GLU A . n 
A 1 161 PHE 161 141 141 PHE PHE A . n 
A 1 162 MET 162 142 142 MET MET A . n 
A 1 163 ASN 163 143 143 ASN ASN A . n 
A 1 164 PRO 164 144 144 PRO PRO A . n 
A 1 165 CYS 165 145 145 CYS CYS A . n 
A 1 166 GLU 166 146 146 GLU GLU A . n 
A 1 167 GLN 167 147 147 GLN GLN A . n 
A 1 168 PHE 168 148 148 PHE PHE A . n 
A 1 169 ARG 169 149 149 ARG ARG A . n 
A 1 170 SER 170 150 150 SER SER A . n 
A 1 171 LEU 171 151 151 LEU LEU A . n 
A 1 172 GLY 172 152 152 GLY GLY A . n 
A 1 173 ILE 173 153 153 ILE ILE A . n 
A 1 174 GLU 174 154 154 GLU GLU A . n 
A 1 175 VAL 175 155 155 VAL VAL A . n 
A 1 176 PRO 176 156 156 PRO PRO A . n 
A 1 177 GLU 177 157 157 GLU GLU A . n 
A 1 178 VAL 178 158 158 VAL VAL A . n 
A 1 179 ARG 179 159 159 ARG ARG A . n 
A 1 180 ARG 180 160 160 ARG ARG A . n 
A 1 181 ASP 181 161 161 ASP ASP A . n 
A 1 182 GLY 182 162 162 GLY GLY A . n 
A 1 183 LEU 183 163 163 LEU LEU A . n 
A 1 184 PRO 184 164 164 PRO PRO A . n 
A 1 185 SER 185 165 165 SER SER A . n 
B 1 1   MET 1   -19 ?   ?   ?   B . n 
B 1 2   GLY 2   -18 ?   ?   ?   B . n 
B 1 3   SER 3   -17 ?   ?   ?   B . n 
B 1 4   SER 4   -16 ?   ?   ?   B . n 
B 1 5   HIS 5   -15 ?   ?   ?   B . n 
B 1 6   HIS 6   -14 ?   ?   ?   B . n 
B 1 7   HIS 7   -13 ?   ?   ?   B . n 
B 1 8   HIS 8   -12 ?   ?   ?   B . n 
B 1 9   HIS 9   -11 ?   ?   ?   B . n 
B 1 10  HIS 10  -10 ?   ?   ?   B . n 
B 1 11  SER 11  -9  ?   ?   ?   B . n 
B 1 12  SER 12  -8  ?   ?   ?   B . n 
B 1 13  GLY 13  -7  ?   ?   ?   B . n 
B 1 14  LEU 14  -6  ?   ?   ?   B . n 
B 1 15  VAL 15  -5  ?   ?   ?   B . n 
B 1 16  PRO 16  -4  ?   ?   ?   B . n 
B 1 17  ARG 17  -3  ?   ?   ?   B . n 
B 1 18  GLY 18  -2  ?   ?   ?   B . n 
B 1 19  SER 19  -1  ?   ?   ?   B . n 
B 1 20  HIS 20  0   ?   ?   ?   B . n 
B 1 21  MET 21  1   ?   ?   ?   B . n 
B 1 22  SER 22  2   ?   ?   ?   B . n 
B 1 23  ASP 23  3   ?   ?   ?   B . n 
B 1 24  VAL 24  4   ?   ?   ?   B . n 
B 1 25  GLU 25  5   ?   ?   ?   B . n 
B 1 26  SER 26  6   ?   ?   ?   B . n 
B 1 27  LEU 27  7   ?   ?   ?   B . n 
B 1 28  GLU 28  8   ?   ?   ?   B . n 
B 1 29  ASN 29  9   ?   ?   ?   B . n 
B 1 30  THR 30  10  ?   ?   ?   B . n 
B 1 31  SER 31  11  ?   ?   ?   B . n 
B 1 32  GLU 32  12  ?   ?   ?   B . n 
B 1 33  ASN 33  13  13  ASN ASN B . n 
B 1 34  ARG 34  14  14  ARG ARG B . n 
B 1 35  ALA 35  15  15  ALA ALA B . n 
B 1 36  GLN 36  16  16  GLN GLN B . n 
B 1 37  VAL 37  17  17  VAL VAL B . n 
B 1 38  ALA 38  18  18  ALA ALA B . n 
B 1 39  ALA 39  19  19  ALA ALA B . n 
B 1 40  ARG 40  20  20  ARG ARG B . n 
B 1 41  GLN 41  21  21  GLN GLN B . n 
B 1 42  HIS 42  22  22  HIS HIS B . n 
B 1 43  ASN 43  23  23  ASN ASN B . n 
B 1 44  ARG 44  24  24  ARG ARG B . n 
B 1 45  LYS 45  25  25  LYS LYS B . n 
B 1 46  ILE 46  26  26  ILE ILE B . n 
B 1 47  VAL 47  27  27  VAL VAL B . n 
B 1 48  GLU 48  28  28  GLU GLU B . n 
B 1 49  GLN 49  29  29  GLN GLN B . n 
B 1 50  TYR 50  30  30  TYR TYR B . n 
B 1 51  MET 51  31  31  MET MET B . n 
B 1 52  HIS 52  32  32  HIS HIS B . n 
B 1 53  THR 53  33  33  THR THR B . n 
B 1 54  ARG 54  34  34  ARG ARG B . n 
B 1 55  GLY 55  35  35  GLY GLY B . n 
B 1 56  GLU 56  36  36  GLU GLU B . n 
B 1 57  ALA 57  37  37  ALA ALA B . n 
B 1 58  ARG 58  38  38  ARG ARG B . n 
B 1 59  LEU 59  39  39  LEU LEU B . n 
B 1 60  LYS 60  40  40  LYS LYS B . n 
B 1 61  ARG 61  41  41  ARG ARG B . n 
B 1 62  HIS 62  42  42  HIS HIS B . n 
B 1 63  LEU 63  43  43  LEU LEU B . n 
B 1 64  LEU 64  44  44  LEU LEU B . n 
B 1 65  PHE 65  45  45  PHE PHE B . n 
B 1 66  THR 66  46  46  THR THR B . n 
B 1 67  GLU 67  47  47  GLU GLU B . n 
B 1 68  ASP 68  48  48  ASP ASP B . n 
B 1 69  GLY 69  49  49  GLY GLY B . n 
B 1 70  VAL 70  50  50  VAL VAL B . n 
B 1 71  GLY 71  51  51  GLY GLY B . n 
B 1 72  GLY 72  52  52  GLY GLY B . n 
B 1 73  LEU 73  53  53  LEU LEU B . n 
B 1 74  TRP 74  54  54  TRP TRP B . n 
B 1 75  THR 75  55  55  THR THR B . n 
B 1 76  THR 76  56  56  THR THR B . n 
B 1 77  ASP 77  57  57  ASP ASP B . n 
B 1 78  SER 78  58  58  SER SER B . n 
B 1 79  GLY 79  59  59  GLY GLY B . n 
B 1 80  GLN 80  60  60  GLN GLN B . n 
B 1 81  PRO 81  61  61  PRO PRO B . n 
B 1 82  ILE 82  62  62  ILE ILE B . n 
B 1 83  ALA 83  63  63  ALA ALA B . n 
B 1 84  ILE 84  64  64  ILE ILE B . n 
B 1 85  ARG 85  65  65  ARG ARG B . n 
B 1 86  GLY 86  66  66  GLY GLY B . n 
B 1 87  ARG 87  67  67  ARG ARG B . n 
B 1 88  GLU 88  68  68  GLU GLU B . n 
B 1 89  LYS 89  69  69  LYS LYS B . n 
B 1 90  LEU 90  70  70  LEU LEU B . n 
B 1 91  GLY 91  71  71  GLY GLY B . n 
B 1 92  GLU 92  72  72  GLU GLU B . n 
B 1 93  HIS 93  73  73  HIS HIS B . n 
B 1 94  ALA 94  74  74  ALA ALA B . n 
B 1 95  VAL 95  75  75  VAL VAL B . n 
B 1 96  TRP 96  76  76  TRP TRP B . n 
B 1 97  SER 97  77  77  SER SER B . n 
B 1 98  LEU 98  78  78  LEU LEU B . n 
B 1 99  GLN 99  79  79  GLN GLN B . n 
B 1 100 CYS 100 80  80  CYS CYS B . n 
B 1 101 PHE 101 81  81  PHE PHE B . n 
B 1 102 PRO 102 82  82  PRO PRO B . n 
B 1 103 ASP 103 83  83  ASP ASP B . n 
B 1 104 TRP 104 84  84  TRP TRP B . n 
B 1 105 VAL 105 85  85  VAL VAL B . n 
B 1 106 TRP 106 86  86  TRP TRP B . n 
B 1 107 THR 107 87  87  THR THR B . n 
B 1 108 ASP 108 88  88  ASP ASP B . n 
B 1 109 ILE 109 89  89  ILE ILE B . n 
B 1 110 GLN 110 90  90  GLN GLN B . n 
B 1 111 ILE 111 91  91  ILE ILE B . n 
B 1 112 PHE 112 92  92  PHE PHE B . n 
B 1 113 GLU 113 93  93  GLU GLU B . n 
B 1 114 THR 114 94  94  THR THR B . n 
B 1 115 GLN 115 95  95  GLN GLN B . n 
B 1 116 ASP 116 96  96  ASP ASP B . n 
B 1 117 PRO 117 97  97  PRO PRO B . n 
B 1 118 ASN 118 98  98  ASN ASN B . n 
B 1 119 TRP 119 99  99  TRP TRP B . n 
B 1 120 PHE 120 100 100 PHE PHE B . n 
B 1 121 TRP 121 101 101 TRP TRP B . n 
B 1 122 VAL 122 102 102 VAL VAL B . n 
B 1 123 GLU 123 103 103 GLU GLU B . n 
B 1 124 CYS 124 104 104 CYS CYS B . n 
B 1 125 ARG 125 105 105 ARG ARG B . n 
B 1 126 GLY 126 106 106 GLY GLY B . n 
B 1 127 GLU 127 107 107 GLU GLU B . n 
B 1 128 GLY 128 108 108 GLY GLY B . n 
B 1 129 ALA 129 109 109 ALA ALA B . n 
B 1 130 ILE 130 110 110 ILE ILE B . n 
B 1 131 VAL 131 111 111 VAL VAL B . n 
B 1 132 PHE 132 112 112 PHE PHE B . n 
B 1 133 PRO 133 113 113 PRO PRO B . n 
B 1 134 GLY 134 114 114 GLY GLY B . n 
B 1 135 TYR 135 115 115 TYR TYR B . n 
B 1 136 PRO 136 116 116 PRO PRO B . n 
B 1 137 ARG 137 117 117 ARG ARG B . n 
B 1 138 GLY 138 118 118 GLY GLY B . n 
B 1 139 GLN 139 119 119 GLN GLN B . n 
B 1 140 TYR 140 120 120 TYR TYR B . n 
B 1 141 ARG 141 121 121 ARG ARG B . n 
B 1 142 ASN 142 122 122 ASN ASN B . n 
B 1 143 HIS 143 123 123 HIS HIS B . n 
B 1 144 PHE 144 124 124 PHE PHE B . n 
B 1 145 LEU 145 125 125 LEU LEU B . n 
B 1 146 HIS 146 126 126 HIS HIS B . n 
B 1 147 SER 147 127 127 SER SER B . n 
B 1 148 PHE 148 128 128 PHE PHE B . n 
B 1 149 ARG 149 129 129 ARG ARG B . n 
B 1 150 PHE 150 130 130 PHE PHE B . n 
B 1 151 GLU 151 131 131 GLU GLU B . n 
B 1 152 ASN 152 132 132 ASN ASN B . n 
B 1 153 GLY 153 133 133 GLY GLY B . n 
B 1 154 LEU 154 134 134 LEU LEU B . n 
B 1 155 ILE 155 135 135 ILE ILE B . n 
B 1 156 LYS 156 136 136 LYS LYS B . n 
B 1 157 GLU 157 137 137 GLU GLU B . n 
B 1 158 GLN 158 138 138 GLN GLN B . n 
B 1 159 ARG 159 139 139 ARG ARG B . n 
B 1 160 GLU 160 140 140 GLU GLU B . n 
B 1 161 PHE 161 141 141 PHE PHE B . n 
B 1 162 MET 162 142 142 MET MET B . n 
B 1 163 ASN 163 143 143 ASN ASN B . n 
B 1 164 PRO 164 144 144 PRO PRO B . n 
B 1 165 CYS 165 145 145 CYS CYS B . n 
B 1 166 GLU 166 146 146 GLU GLU B . n 
B 1 167 GLN 167 147 147 GLN GLN B . n 
B 1 168 PHE 168 148 148 PHE PHE B . n 
B 1 169 ARG 169 149 149 ARG ARG B . n 
B 1 170 SER 170 150 150 SER SER B . n 
B 1 171 LEU 171 151 151 LEU LEU B . n 
B 1 172 GLY 172 152 152 GLY GLY B . n 
B 1 173 ILE 173 153 153 ILE ILE B . n 
B 1 174 GLU 174 154 154 GLU GLU B . n 
B 1 175 VAL 175 155 155 VAL VAL B . n 
B 1 176 PRO 176 156 156 PRO PRO B . n 
B 1 177 GLU 177 157 157 GLU GLU B . n 
B 1 178 VAL 178 158 158 VAL VAL B . n 
B 1 179 ARG 179 159 159 ARG ARG B . n 
B 1 180 ARG 180 160 160 ARG ARG B . n 
B 1 181 ASP 181 161 161 ASP ASP B . n 
B 1 182 GLY 182 162 162 GLY GLY B . n 
B 1 183 LEU 183 163 163 LEU LEU B . n 
B 1 184 PRO 184 164 164 PRO PRO B . n 
B 1 185 SER 185 165 165 SER SER B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1IAH 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1IAH 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 GOL   1   201 202 GOL   GOL A . 
D 2 GOL   1   202 203 GOL   GOL A . 
E 2 GOL   1   203 203 GOL   GOL A . 
F 3 ACT   1   201 201 ACT   ACT B . 
G 2 GOL   1   202 201 GOL   GOL B . 
H 4 A1IAH 1   203 205 A1IAH T33 B . 
I 5 HOH   1   301 354 HOH   HOH A . 
I 5 HOH   2   302 382 HOH   HOH A . 
I 5 HOH   3   303 118 HOH   HOH A . 
I 5 HOH   4   304 380 HOH   HOH A . 
I 5 HOH   5   305 448 HOH   HOH A . 
I 5 HOH   6   306 410 HOH   HOH A . 
I 5 HOH   7   307 213 HOH   HOH A . 
I 5 HOH   8   308 192 HOH   HOH A . 
I 5 HOH   9   309 62  HOH   HOH A . 
I 5 HOH   10  310 36  HOH   HOH A . 
I 5 HOH   11  311 60  HOH   HOH A . 
I 5 HOH   12  312 405 HOH   HOH A . 
I 5 HOH   13  313 420 HOH   HOH A . 
I 5 HOH   14  314 202 HOH   HOH A . 
I 5 HOH   15  315 56  HOH   HOH A . 
I 5 HOH   16  316 77  HOH   HOH A . 
I 5 HOH   17  317 216 HOH   HOH A . 
I 5 HOH   18  318 112 HOH   HOH A . 
I 5 HOH   19  319 378 HOH   HOH A . 
I 5 HOH   20  320 432 HOH   HOH A . 
I 5 HOH   21  321 105 HOH   HOH A . 
I 5 HOH   22  322 377 HOH   HOH A . 
I 5 HOH   23  323 206 HOH   HOH A . 
I 5 HOH   24  324 181 HOH   HOH A . 
I 5 HOH   25  325 99  HOH   HOH A . 
I 5 HOH   26  326 315 HOH   HOH A . 
I 5 HOH   27  327 396 HOH   HOH A . 
I 5 HOH   28  328 195 HOH   HOH A . 
I 5 HOH   29  329 324 HOH   HOH A . 
I 5 HOH   30  330 144 HOH   HOH A . 
I 5 HOH   31  331 116 HOH   HOH A . 
I 5 HOH   32  332 2   HOH   HOH A . 
I 5 HOH   33  333 230 HOH   HOH A . 
I 5 HOH   34  334 114 HOH   HOH A . 
I 5 HOH   35  335 171 HOH   HOH A . 
I 5 HOH   36  336 176 HOH   HOH A . 
I 5 HOH   37  337 175 HOH   HOH A . 
I 5 HOH   38  338 5   HOH   HOH A . 
I 5 HOH   39  339 93  HOH   HOH A . 
I 5 HOH   40  340 64  HOH   HOH A . 
I 5 HOH   41  341 212 HOH   HOH A . 
I 5 HOH   42  342 44  HOH   HOH A . 
I 5 HOH   43  343 29  HOH   HOH A . 
I 5 HOH   44  344 263 HOH   HOH A . 
I 5 HOH   45  345 248 HOH   HOH A . 
I 5 HOH   46  346 329 HOH   HOH A . 
I 5 HOH   47  347 22  HOH   HOH A . 
I 5 HOH   48  348 74  HOH   HOH A . 
I 5 HOH   49  349 45  HOH   HOH A . 
I 5 HOH   50  350 7   HOH   HOH A . 
I 5 HOH   51  351 223 HOH   HOH A . 
I 5 HOH   52  352 82  HOH   HOH A . 
I 5 HOH   53  353 217 HOH   HOH A . 
I 5 HOH   54  354 128 HOH   HOH A . 
I 5 HOH   55  355 328 HOH   HOH A . 
I 5 HOH   56  356 71  HOH   HOH A . 
I 5 HOH   57  357 46  HOH   HOH A . 
I 5 HOH   58  358 54  HOH   HOH A . 
I 5 HOH   59  359 428 HOH   HOH A . 
I 5 HOH   60  360 209 HOH   HOH A . 
I 5 HOH   61  361 51  HOH   HOH A . 
I 5 HOH   62  362 125 HOH   HOH A . 
I 5 HOH   63  363 219 HOH   HOH A . 
I 5 HOH   64  364 18  HOH   HOH A . 
I 5 HOH   65  365 249 HOH   HOH A . 
I 5 HOH   66  366 73  HOH   HOH A . 
I 5 HOH   67  367 159 HOH   HOH A . 
I 5 HOH   68  368 215 HOH   HOH A . 
I 5 HOH   69  369 327 HOH   HOH A . 
I 5 HOH   70  370 278 HOH   HOH A . 
I 5 HOH   71  371 49  HOH   HOH A . 
I 5 HOH   72  372 103 HOH   HOH A . 
I 5 HOH   73  373 204 HOH   HOH A . 
I 5 HOH   74  374 177 HOH   HOH A . 
I 5 HOH   75  375 69  HOH   HOH A . 
I 5 HOH   76  376 264 HOH   HOH A . 
I 5 HOH   77  377 178 HOH   HOH A . 
I 5 HOH   78  378 17  HOH   HOH A . 
I 5 HOH   79  379 185 HOH   HOH A . 
I 5 HOH   80  380 138 HOH   HOH A . 
I 5 HOH   81  381 419 HOH   HOH A . 
I 5 HOH   82  382 83  HOH   HOH A . 
I 5 HOH   83  383 10  HOH   HOH A . 
I 5 HOH   84  384 233 HOH   HOH A . 
I 5 HOH   85  385 379 HOH   HOH A . 
I 5 HOH   86  386 326 HOH   HOH A . 
I 5 HOH   87  387 271 HOH   HOH A . 
I 5 HOH   88  388 135 HOH   HOH A . 
I 5 HOH   89  389 198 HOH   HOH A . 
I 5 HOH   90  390 282 HOH   HOH A . 
I 5 HOH   91  391 111 HOH   HOH A . 
I 5 HOH   92  392 273 HOH   HOH A . 
I 5 HOH   93  393 404 HOH   HOH A . 
I 5 HOH   94  394 339 HOH   HOH A . 
I 5 HOH   95  395 179 HOH   HOH A . 
I 5 HOH   96  396 101 HOH   HOH A . 
I 5 HOH   97  397 127 HOH   HOH A . 
I 5 HOH   98  398 290 HOH   HOH A . 
I 5 HOH   99  399 102 HOH   HOH A . 
I 5 HOH   100 400 236 HOH   HOH A . 
I 5 HOH   101 401 33  HOH   HOH A . 
I 5 HOH   102 402 357 HOH   HOH A . 
I 5 HOH   103 403 61  HOH   HOH A . 
I 5 HOH   104 404 34  HOH   HOH A . 
I 5 HOH   105 405 21  HOH   HOH A . 
I 5 HOH   106 406 220 HOH   HOH A . 
I 5 HOH   107 407 92  HOH   HOH A . 
I 5 HOH   108 408 309 HOH   HOH A . 
I 5 HOH   109 409 194 HOH   HOH A . 
I 5 HOH   110 410 48  HOH   HOH A . 
I 5 HOH   111 411 196 HOH   HOH A . 
I 5 HOH   112 412 79  HOH   HOH A . 
I 5 HOH   113 413 115 HOH   HOH A . 
I 5 HOH   114 414 186 HOH   HOH A . 
I 5 HOH   115 415 122 HOH   HOH A . 
I 5 HOH   116 416 37  HOH   HOH A . 
I 5 HOH   117 417 108 HOH   HOH A . 
I 5 HOH   118 418 155 HOH   HOH A . 
I 5 HOH   119 419 443 HOH   HOH A . 
I 5 HOH   120 420 95  HOH   HOH A . 
I 5 HOH   121 421 133 HOH   HOH A . 
I 5 HOH   122 422 385 HOH   HOH A . 
I 5 HOH   123 423 164 HOH   HOH A . 
I 5 HOH   124 424 386 HOH   HOH A . 
I 5 HOH   125 425 376 HOH   HOH A . 
I 5 HOH   126 426 183 HOH   HOH A . 
I 5 HOH   127 427 119 HOH   HOH A . 
I 5 HOH   128 428 383 HOH   HOH A . 
I 5 HOH   129 429 340 HOH   HOH A . 
I 5 HOH   130 430 205 HOH   HOH A . 
I 5 HOH   131 431 292 HOH   HOH A . 
I 5 HOH   132 432 132 HOH   HOH A . 
I 5 HOH   133 433 40  HOH   HOH A . 
I 5 HOH   134 434 184 HOH   HOH A . 
I 5 HOH   135 435 88  HOH   HOH A . 
I 5 HOH   136 436 262 HOH   HOH A . 
I 5 HOH   137 437 454 HOH   HOH A . 
I 5 HOH   138 438 412 HOH   HOH A . 
I 5 HOH   139 439 384 HOH   HOH A . 
I 5 HOH   140 440 288 HOH   HOH A . 
I 5 HOH   141 441 234 HOH   HOH A . 
I 5 HOH   142 442 255 HOH   HOH A . 
I 5 HOH   143 443 227 HOH   HOH A . 
I 5 HOH   144 444 435 HOH   HOH A . 
I 5 HOH   145 445 330 HOH   HOH A . 
I 5 HOH   146 446 252 HOH   HOH A . 
I 5 HOH   147 447 434 HOH   HOH A . 
I 5 HOH   148 448 399 HOH   HOH A . 
I 5 HOH   149 449 395 HOH   HOH A . 
I 5 HOH   150 450 168 HOH   HOH A . 
I 5 HOH   151 451 147 HOH   HOH A . 
I 5 HOH   152 452 421 HOH   HOH A . 
I 5 HOH   153 453 307 HOH   HOH A . 
I 5 HOH   154 454 308 HOH   HOH A . 
I 5 HOH   155 455 426 HOH   HOH A . 
I 5 HOH   156 456 390 HOH   HOH A . 
I 5 HOH   157 457 200 HOH   HOH A . 
I 5 HOH   158 458 281 HOH   HOH A . 
I 5 HOH   159 459 407 HOH   HOH A . 
I 5 HOH   160 460 289 HOH   HOH A . 
I 5 HOH   161 461 316 HOH   HOH A . 
I 5 HOH   162 462 130 HOH   HOH A . 
I 5 HOH   163 463 287 HOH   HOH A . 
I 5 HOH   164 464 260 HOH   HOH A . 
I 5 HOH   165 465 355 HOH   HOH A . 
I 5 HOH   166 466 347 HOH   HOH A . 
I 5 HOH   167 467 356 HOH   HOH A . 
I 5 HOH   168 468 167 HOH   HOH A . 
I 5 HOH   169 469 269 HOH   HOH A . 
I 5 HOH   170 470 259 HOH   HOH A . 
I 5 HOH   171 471 391 HOH   HOH A . 
I 5 HOH   172 472 314 HOH   HOH A . 
I 5 HOH   173 473 393 HOH   HOH A . 
I 5 HOH   174 474 310 HOH   HOH A . 
I 5 HOH   175 475 291 HOH   HOH A . 
I 5 HOH   176 476 317 HOH   HOH A . 
I 5 HOH   177 477 323 HOH   HOH A . 
I 5 HOH   178 478 406 HOH   HOH A . 
I 5 HOH   179 479 381 HOH   HOH A . 
I 5 HOH   180 480 242 HOH   HOH A . 
I 5 HOH   181 481 280 HOH   HOH A . 
I 5 HOH   182 482 232 HOH   HOH A . 
I 5 HOH   183 483 258 HOH   HOH A . 
J 5 HOH   1   301 442 HOH   HOH B . 
J 5 HOH   2   302 402 HOH   HOH B . 
J 5 HOH   3   303 166 HOH   HOH B . 
J 5 HOH   4   304 449 HOH   HOH B . 
J 5 HOH   5   305 126 HOH   HOH B . 
J 5 HOH   6   306 90  HOH   HOH B . 
J 5 HOH   7   307 423 HOH   HOH B . 
J 5 HOH   8   308 239 HOH   HOH B . 
J 5 HOH   9   309 451 HOH   HOH B . 
J 5 HOH   10  310 131 HOH   HOH B . 
J 5 HOH   11  311 86  HOH   HOH B . 
J 5 HOH   12  312 94  HOH   HOH B . 
J 5 HOH   13  313 58  HOH   HOH B . 
J 5 HOH   14  314 440 HOH   HOH B . 
J 5 HOH   15  315 201 HOH   HOH B . 
J 5 HOH   16  316 446 HOH   HOH B . 
J 5 HOH   17  317 447 HOH   HOH B . 
J 5 HOH   18  318 322 HOH   HOH B . 
J 5 HOH   19  319 129 HOH   HOH B . 
J 5 HOH   20  320 43  HOH   HOH B . 
J 5 HOH   21  321 156 HOH   HOH B . 
J 5 HOH   22  322 41  HOH   HOH B . 
J 5 HOH   23  323 67  HOH   HOH B . 
J 5 HOH   24  324 312 HOH   HOH B . 
J 5 HOH   25  325 11  HOH   HOH B . 
J 5 HOH   26  326 431 HOH   HOH B . 
J 5 HOH   27  327 42  HOH   HOH B . 
J 5 HOH   28  328 146 HOH   HOH B . 
J 5 HOH   29  329 4   HOH   HOH B . 
J 5 HOH   30  330 39  HOH   HOH B . 
J 5 HOH   31  331 189 HOH   HOH B . 
J 5 HOH   32  332 257 HOH   HOH B . 
J 5 HOH   33  333 52  HOH   HOH B . 
J 5 HOH   34  334 27  HOH   HOH B . 
J 5 HOH   35  335 96  HOH   HOH B . 
J 5 HOH   36  336 425 HOH   HOH B . 
J 5 HOH   37  337 450 HOH   HOH B . 
J 5 HOH   38  338 172 HOH   HOH B . 
J 5 HOH   39  339 365 HOH   HOH B . 
J 5 HOH   40  340 106 HOH   HOH B . 
J 5 HOH   41  341 28  HOH   HOH B . 
J 5 HOH   42  342 222 HOH   HOH B . 
J 5 HOH   43  343 190 HOH   HOH B . 
J 5 HOH   44  344 123 HOH   HOH B . 
J 5 HOH   45  345 148 HOH   HOH B . 
J 5 HOH   46  346 152 HOH   HOH B . 
J 5 HOH   47  347 15  HOH   HOH B . 
J 5 HOH   48  348 23  HOH   HOH B . 
J 5 HOH   49  349 3   HOH   HOH B . 
J 5 HOH   50  350 76  HOH   HOH B . 
J 5 HOH   51  351 63  HOH   HOH B . 
J 5 HOH   52  352 294 HOH   HOH B . 
J 5 HOH   53  353 30  HOH   HOH B . 
J 5 HOH   54  354 55  HOH   HOH B . 
J 5 HOH   55  355 418 HOH   HOH B . 
J 5 HOH   56  356 12  HOH   HOH B . 
J 5 HOH   57  357 121 HOH   HOH B . 
J 5 HOH   58  358 6   HOH   HOH B . 
J 5 HOH   59  359 361 HOH   HOH B . 
J 5 HOH   60  360 9   HOH   HOH B . 
J 5 HOH   61  361 221 HOH   HOH B . 
J 5 HOH   62  362 137 HOH   HOH B . 
J 5 HOH   63  363 16  HOH   HOH B . 
J 5 HOH   64  364 38  HOH   HOH B . 
J 5 HOH   65  365 229 HOH   HOH B . 
J 5 HOH   66  366 151 HOH   HOH B . 
J 5 HOH   67  367 409 HOH   HOH B . 
J 5 HOH   68  368 240 HOH   HOH B . 
J 5 HOH   69  369 170 HOH   HOH B . 
J 5 HOH   70  370 218 HOH   HOH B . 
J 5 HOH   71  371 180 HOH   HOH B . 
J 5 HOH   72  372 140 HOH   HOH B . 
J 5 HOH   73  373 160 HOH   HOH B . 
J 5 HOH   74  374 265 HOH   HOH B . 
J 5 HOH   75  375 91  HOH   HOH B . 
J 5 HOH   76  376 161 HOH   HOH B . 
J 5 HOH   77  377 19  HOH   HOH B . 
J 5 HOH   78  378 75  HOH   HOH B . 
J 5 HOH   79  379 107 HOH   HOH B . 
J 5 HOH   80  380 266 HOH   HOH B . 
J 5 HOH   81  381 244 HOH   HOH B . 
J 5 HOH   82  382 389 HOH   HOH B . 
J 5 HOH   83  383 374 HOH   HOH B . 
J 5 HOH   84  384 8   HOH   HOH B . 
J 5 HOH   85  385 32  HOH   HOH B . 
J 5 HOH   86  386 47  HOH   HOH B . 
J 5 HOH   87  387 35  HOH   HOH B . 
J 5 HOH   88  388 142 HOH   HOH B . 
J 5 HOH   89  389 14  HOH   HOH B . 
J 5 HOH   90  390 429 HOH   HOH B . 
J 5 HOH   91  391 110 HOH   HOH B . 
J 5 HOH   92  392 139 HOH   HOH B . 
J 5 HOH   93  393 251 HOH   HOH B . 
J 5 HOH   94  394 321 HOH   HOH B . 
J 5 HOH   95  395 369 HOH   HOH B . 
J 5 HOH   96  396 191 HOH   HOH B . 
J 5 HOH   97  397 66  HOH   HOH B . 
J 5 HOH   98  398 270 HOH   HOH B . 
J 5 HOH   99  399 149 HOH   HOH B . 
J 5 HOH   100 400 424 HOH   HOH B . 
J 5 HOH   101 401 226 HOH   HOH B . 
J 5 HOH   102 402 59  HOH   HOH B . 
J 5 HOH   103 403 85  HOH   HOH B . 
J 5 HOH   104 404 141 HOH   HOH B . 
J 5 HOH   105 405 416 HOH   HOH B . 
J 5 HOH   106 406 97  HOH   HOH B . 
J 5 HOH   107 407 143 HOH   HOH B . 
J 5 HOH   108 408 344 HOH   HOH B . 
J 5 HOH   109 409 87  HOH   HOH B . 
J 5 HOH   110 410 117 HOH   HOH B . 
J 5 HOH   111 411 452 HOH   HOH B . 
J 5 HOH   112 412 120 HOH   HOH B . 
J 5 HOH   113 413 134 HOH   HOH B . 
J 5 HOH   114 414 24  HOH   HOH B . 
J 5 HOH   115 415 136 HOH   HOH B . 
J 5 HOH   116 416 109 HOH   HOH B . 
J 5 HOH   117 417 157 HOH   HOH B . 
J 5 HOH   118 418 100 HOH   HOH B . 
J 5 HOH   119 419 210 HOH   HOH B . 
J 5 HOH   120 420 197 HOH   HOH B . 
J 5 HOH   121 421 174 HOH   HOH B . 
J 5 HOH   122 422 154 HOH   HOH B . 
J 5 HOH   123 423 306 HOH   HOH B . 
J 5 HOH   124 424 253 HOH   HOH B . 
J 5 HOH   125 425 284 HOH   HOH B . 
J 5 HOH   126 426 150 HOH   HOH B . 
J 5 HOH   127 427 293 HOH   HOH B . 
J 5 HOH   128 428 332 HOH   HOH B . 
J 5 HOH   129 429 373 HOH   HOH B . 
J 5 HOH   130 430 89  HOH   HOH B . 
J 5 HOH   131 431 104 HOH   HOH B . 
J 5 HOH   132 432 254 HOH   HOH B . 
J 5 HOH   133 433 250 HOH   HOH B . 
J 5 HOH   134 434 445 HOH   HOH B . 
J 5 HOH   135 435 268 HOH   HOH B . 
J 5 HOH   136 436 364 HOH   HOH B . 
J 5 HOH   137 437 113 HOH   HOH B . 
J 5 HOH   138 438 225 HOH   HOH B . 
J 5 HOH   139 439 169 HOH   HOH B . 
J 5 HOH   140 440 433 HOH   HOH B . 
J 5 HOH   141 441 162 HOH   HOH B . 
J 5 HOH   142 442 331 HOH   HOH B . 
J 5 HOH   143 443 441 HOH   HOH B . 
J 5 HOH   144 444 84  HOH   HOH B . 
J 5 HOH   145 445 325 HOH   HOH B . 
J 5 HOH   146 446 400 HOH   HOH B . 
J 5 HOH   147 447 214 HOH   HOH B . 
J 5 HOH   148 448 370 HOH   HOH B . 
J 5 HOH   149 449 299 HOH   HOH B . 
J 5 HOH   150 450 375 HOH   HOH B . 
J 5 HOH   151 451 31  HOH   HOH B . 
J 5 HOH   152 452 350 HOH   HOH B . 
J 5 HOH   153 453 341 HOH   HOH B . 
J 5 HOH   154 454 247 HOH   HOH B . 
J 5 HOH   155 455 403 HOH   HOH B . 
J 5 HOH   156 456 371 HOH   HOH B . 
J 5 HOH   157 457 392 HOH   HOH B . 
J 5 HOH   158 458 286 HOH   HOH B . 
J 5 HOH   159 459 368 HOH   HOH B . 
J 5 HOH   160 460 388 HOH   HOH B . 
J 5 HOH   161 461 70  HOH   HOH B . 
J 5 HOH   162 462 295 HOH   HOH B . 
J 5 HOH   163 463 246 HOH   HOH B . 
J 5 HOH   164 464 207 HOH   HOH B . 
J 5 HOH   165 465 245 HOH   HOH B . 
J 5 HOH   166 466 349 HOH   HOH B . 
J 5 HOH   167 467 360 HOH   HOH B . 
J 5 HOH   168 468 363 HOH   HOH B . 
J 5 HOH   169 469 285 HOH   HOH B . 
J 5 HOH   170 470 173 HOH   HOH B . 
J 5 HOH   171 471 358 HOH   HOH B . 
J 5 HOH   172 472 187 HOH   HOH B . 
J 5 HOH   173 473 427 HOH   HOH B . 
J 5 HOH   174 474 224 HOH   HOH B . 
J 5 HOH   175 475 283 HOH   HOH B . 
J 5 HOH   176 476 267 HOH   HOH B . 
J 5 HOH   177 477 241 HOH   HOH B . 
J 5 HOH   178 478 145 HOH   HOH B . 
J 5 HOH   179 479 444 HOH   HOH B . 
J 5 HOH   180 480 367 HOH   HOH B . 
J 5 HOH   181 481 372 HOH   HOH B . 
J 5 HOH   182 482 453 HOH   HOH B . 
J 5 HOH   183 483 430 HOH   HOH B . 
J 5 HOH   184 484 235 HOH   HOH B . 
J 5 HOH   185 485 303 HOH   HOH B . 
J 5 HOH   186 486 346 HOH   HOH B . 
J 5 HOH   187 487 208 HOH   HOH B . 
J 5 HOH   188 488 320 HOH   HOH B . 
J 5 HOH   189 489 188 HOH   HOH B . 
J 5 HOH   190 490 333 HOH   HOH B . 
J 5 HOH   191 491 362 HOH   HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 12  ? CG  ? A GLU 32  CG  
2  1 Y 1 A GLU 12  ? CD  ? A GLU 32  CD  
3  1 Y 1 A GLU 12  ? OE1 ? A GLU 32  OE1 
4  1 Y 1 A GLU 12  ? OE2 ? A GLU 32  OE2 
5  1 Y 1 A ASN 13  ? CG  ? A ASN 33  CG  
6  1 Y 1 A ASN 13  ? OD1 ? A ASN 33  OD1 
7  1 Y 1 A ASN 13  ? ND2 ? A ASN 33  ND2 
8  1 Y 1 A ARG 14  ? CG  ? A ARG 34  CG  
9  1 Y 1 A ARG 14  ? CD  ? A ARG 34  CD  
10 1 Y 1 A ARG 14  ? NE  ? A ARG 34  NE  
11 1 Y 1 A ARG 14  ? CZ  ? A ARG 34  CZ  
12 1 Y 1 A ARG 14  ? NH1 ? A ARG 34  NH1 
13 1 Y 1 A ARG 14  ? NH2 ? A ARG 34  NH2 
14 1 Y 1 A GLN 21  ? CD  ? A GLN 41  CD  
15 1 Y 1 A GLN 21  ? OE1 ? A GLN 41  OE1 
16 1 Y 1 A GLN 21  ? NE2 ? A GLN 41  NE2 
17 1 Y 1 A LYS 69  ? CE  ? A LYS 89  CE  
18 1 Y 1 A LYS 69  ? NZ  ? A LYS 89  NZ  
19 1 Y 1 A GLU 154 ? CD  ? A GLU 174 CD  
20 1 Y 1 A GLU 154 ? OE1 ? A GLU 174 OE1 
21 1 Y 1 A GLU 154 ? OE2 ? A GLU 174 OE2 
22 1 Y 1 A GLU 157 ? CG  ? A GLU 177 CG  
23 1 Y 1 A GLU 157 ? CD  ? A GLU 177 CD  
24 1 Y 1 A GLU 157 ? OE1 ? A GLU 177 OE1 
25 1 Y 1 A GLU 157 ? OE2 ? A GLU 177 OE2 
26 1 Y 1 A SER 165 ? OG  ? A SER 185 OG  
27 1 Y 1 B ARG 14  ? CG  ? B ARG 34  CG  
28 1 Y 1 B ARG 14  ? CD  ? B ARG 34  CD  
29 1 Y 1 B ARG 14  ? NE  ? B ARG 34  NE  
30 1 Y 1 B ARG 14  ? CZ  ? B ARG 34  CZ  
31 1 Y 1 B ARG 14  ? NH1 ? B ARG 34  NH1 
32 1 Y 1 B ARG 14  ? NH2 ? B ARG 34  NH2 
33 1 Y 1 B GLN 16  ? CD  ? B GLN 36  CD  
34 1 Y 1 B GLN 16  ? OE1 ? B GLN 36  OE1 
35 1 Y 1 B GLN 16  ? NE2 ? B GLN 36  NE2 
36 1 Y 1 B GLN 21  ? CD  ? B GLN 41  CD  
37 1 Y 1 B GLN 21  ? OE1 ? B GLN 41  OE1 
38 1 Y 1 B GLN 21  ? NE2 ? B GLN 41  NE2 
39 1 Y 1 B LYS 40  ? CE  ? B LYS 60  CE  
40 1 Y 1 B LYS 40  ? NZ  ? B LYS 60  NZ  
41 1 Y 1 B SER 165 ? OG  ? B SER 185 OG  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS         ? ? ? 'Jun 30, 2023'      1 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? v0.7.9              2 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? v1.20.1-4487        3 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? v2.8.3              4 
? 'data processing' ? ? ? ? ? ? ? ? ? ? ? autoPROC    ? ? ? 'v1.0.5 (20221121)' 5 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? v4.2                6 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   98.41 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9F8K 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     71.363 
_cell.length_a_esd                 ? 
_cell.length_b                     79.303 
_cell.length_b_esd                 ? 
_cell.length_c                     64.064 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9F8K 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9F8K 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.14 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.6 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '25% (w/v) PEG 3350, 0.1 M Bis-TRIS pH 6.37, 0.122 M ammonium acetate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-09-04 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.033 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PETRA III, DESY BEAMLINE P11' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.033 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   P11 
_diffrn_source.pdbx_synchrotron_site       'PETRA III, DESY' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9F8K 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.57 
_reflns.d_resolution_low                               52.73 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     48015 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           96.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.75 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.060 
_reflns.pdbx_Rpim_I_all                                0.028 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       209361 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.053 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.57 
_reflns_shell.d_res_low                                     1.59 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.2 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             6632 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.571 
_reflns_shell.pdbx_Rpim_I_all                               0.287 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.775 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.490 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.075 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9F8K 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.57 
_refine.ls_d_res_low                             42.90 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     48009 
_refine.ls_number_reflns_R_free                  2412 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.70 
_refine.ls_percent_reflns_R_free                 5.02 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1538 
_refine.ls_R_factor_R_free                       0.1749 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1527 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.38 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 16.40 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.15 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.57 
_refine_hist.d_res_low                        42.90 
_refine_hist.number_atoms_solvent             374 
_refine_hist.number_atoms_total               2948 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2518 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         56 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.006  ? 2720 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.945  ? 3690 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 15.078 ? 995  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.054  ? 353  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.009  ? 495  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.57 1.60  . . 119 2152 79.00  . . . . 0.2044 . . . . . . . . . . . 0.2298 
'X-RAY DIFFRACTION' 1.60 1.63  . . 125 2485 90.00  . . . . 0.1918 . . . . . . . . . . . 0.2164 
'X-RAY DIFFRACTION' 1.63 1.67  . . 167 2647 97.00  . . . . 0.1832 . . . . . . . . . . . 0.2230 
'X-RAY DIFFRACTION' 1.67 1.71  . . 134 2722 97.00  . . . . 0.1878 . . . . . . . . . . . 0.2161 
'X-RAY DIFFRACTION' 1.71 1.76  . . 160 2687 98.00  . . . . 0.1766 . . . . . . . . . . . 0.1982 
'X-RAY DIFFRACTION' 1.76 1.81  . . 145 2699 98.00  . . . . 0.1671 . . . . . . . . . . . 0.2039 
'X-RAY DIFFRACTION' 1.81 1.87  . . 145 2701 98.00  . . . . 0.1575 . . . . . . . . . . . 0.1830 
'X-RAY DIFFRACTION' 1.87 1.94  . . 136 2781 99.00  . . . . 0.1540 . . . . . . . . . . . 0.1706 
'X-RAY DIFFRACTION' 1.94 2.01  . . 141 2654 97.00  . . . . 0.1564 . . . . . . . . . . . 0.1959 
'X-RAY DIFFRACTION' 2.01 2.10  . . 148 2734 98.00  . . . . 0.1561 . . . . . . . . . . . 0.1672 
'X-RAY DIFFRACTION' 2.10 2.22  . . 164 2745 99.00  . . . . 0.1500 . . . . . . . . . . . 0.1702 
'X-RAY DIFFRACTION' 2.22 2.35  . . 124 2748 99.00  . . . . 0.1451 . . . . . . . . . . . 0.1600 
'X-RAY DIFFRACTION' 2.35 2.54  . . 132 2797 99.00  . . . . 0.1464 . . . . . . . . . . . 0.1890 
'X-RAY DIFFRACTION' 2.54 2.79  . . 144 2730 99.00  . . . . 0.1523 . . . . . . . . . . . 0.1710 
'X-RAY DIFFRACTION' 2.79 3.19  . . 136 2726 98.00  . . . . 0.1461 . . . . . . . . . . . 0.1752 
'X-RAY DIFFRACTION' 3.19 4.02  . . 131 2798 100.00 . . . . 0.1351 . . . . . . . . . . . 0.1621 
'X-RAY DIFFRACTION' 4.02 42.90 . . 161 2791 98.00  . . . . 0.1562 . . . . . . . . . . . 0.1602 
# 
_struct.entry_id                     9F8K 
_struct.title                        
;Crystal Structure of PhzA/B from Burkholderia cepacia R18194 in complex with [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl](3-isopropylphenyl)methanone
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9F8K 
_struct_keywords.text            
;pyocyanin, phenazine biosynthesis, virulence, inhibitor, ketosteroid-isomerase, cocrystal, PhzA/B, Burkholderia cepacia, BIOSYNTHETIC PROTEIN
;
_struct_keywords.pdbx_keywords   'BIOSYNTHETIC PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 3 ? 
G N N 2 ? 
H N N 4 ? 
I N N 5 ? 
J N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q396C9_BURL3 
_struct_ref.pdbx_db_accession          Q396C9 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSDVESLENTSENRAQVAARQHNRKIVEQYMHTRGEARLKRHLLFTEDGVGGLWTTDSGQPIAIRGREKLGEHAVWSLQC
FPDWVWTDIQIFETQDPNWFWVECRGEGAIVFPGYPRGQYRNHFLHSFRFENGLIKEQREFMNPCEQFRSLGIEVPEVRR
DGLPS
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9F8K A 21 ? 185 ? Q396C9 1 ? 165 ? 1 165 
2 1 9F8K B 21 ? 185 ? Q396C9 1 ? 165 ? 1 165 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9F8K MET A 1  ? UNP Q396C9 ? ? 'initiating methionine' -19 1  
1 9F8K GLY A 2  ? UNP Q396C9 ? ? 'expression tag'        -18 2  
1 9F8K SER A 3  ? UNP Q396C9 ? ? 'expression tag'        -17 3  
1 9F8K SER A 4  ? UNP Q396C9 ? ? 'expression tag'        -16 4  
1 9F8K HIS A 5  ? UNP Q396C9 ? ? 'expression tag'        -15 5  
1 9F8K HIS A 6  ? UNP Q396C9 ? ? 'expression tag'        -14 6  
1 9F8K HIS A 7  ? UNP Q396C9 ? ? 'expression tag'        -13 7  
1 9F8K HIS A 8  ? UNP Q396C9 ? ? 'expression tag'        -12 8  
1 9F8K HIS A 9  ? UNP Q396C9 ? ? 'expression tag'        -11 9  
1 9F8K HIS A 10 ? UNP Q396C9 ? ? 'expression tag'        -10 10 
1 9F8K SER A 11 ? UNP Q396C9 ? ? 'expression tag'        -9  11 
1 9F8K SER A 12 ? UNP Q396C9 ? ? 'expression tag'        -8  12 
1 9F8K GLY A 13 ? UNP Q396C9 ? ? 'expression tag'        -7  13 
1 9F8K LEU A 14 ? UNP Q396C9 ? ? 'expression tag'        -6  14 
1 9F8K VAL A 15 ? UNP Q396C9 ? ? 'expression tag'        -5  15 
1 9F8K PRO A 16 ? UNP Q396C9 ? ? 'expression tag'        -4  16 
1 9F8K ARG A 17 ? UNP Q396C9 ? ? 'expression tag'        -3  17 
1 9F8K GLY A 18 ? UNP Q396C9 ? ? 'expression tag'        -2  18 
1 9F8K SER A 19 ? UNP Q396C9 ? ? 'expression tag'        -1  19 
1 9F8K HIS A 20 ? UNP Q396C9 ? ? 'expression tag'        0   20 
2 9F8K MET B 1  ? UNP Q396C9 ? ? 'initiating methionine' -19 21 
2 9F8K GLY B 2  ? UNP Q396C9 ? ? 'expression tag'        -18 22 
2 9F8K SER B 3  ? UNP Q396C9 ? ? 'expression tag'        -17 23 
2 9F8K SER B 4  ? UNP Q396C9 ? ? 'expression tag'        -16 24 
2 9F8K HIS B 5  ? UNP Q396C9 ? ? 'expression tag'        -15 25 
2 9F8K HIS B 6  ? UNP Q396C9 ? ? 'expression tag'        -14 26 
2 9F8K HIS B 7  ? UNP Q396C9 ? ? 'expression tag'        -13 27 
2 9F8K HIS B 8  ? UNP Q396C9 ? ? 'expression tag'        -12 28 
2 9F8K HIS B 9  ? UNP Q396C9 ? ? 'expression tag'        -11 29 
2 9F8K HIS B 10 ? UNP Q396C9 ? ? 'expression tag'        -10 30 
2 9F8K SER B 11 ? UNP Q396C9 ? ? 'expression tag'        -9  31 
2 9F8K SER B 12 ? UNP Q396C9 ? ? 'expression tag'        -8  32 
2 9F8K GLY B 13 ? UNP Q396C9 ? ? 'expression tag'        -7  33 
2 9F8K LEU B 14 ? UNP Q396C9 ? ? 'expression tag'        -6  34 
2 9F8K VAL B 15 ? UNP Q396C9 ? ? 'expression tag'        -5  35 
2 9F8K PRO B 16 ? UNP Q396C9 ? ? 'expression tag'        -4  36 
2 9F8K ARG B 17 ? UNP Q396C9 ? ? 'expression tag'        -3  37 
2 9F8K GLY B 18 ? UNP Q396C9 ? ? 'expression tag'        -2  38 
2 9F8K SER B 19 ? UNP Q396C9 ? ? 'expression tag'        -1  39 
2 9F8K HIS B 20 ? UNP Q396C9 ? ? 'expression tag'        0   40 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5660  ? 
1 MORE         -26   ? 
1 'SSA (A^2)'  13770 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 GLU A 32  ? HIS A 52  ? GLU A 12  HIS A 32  1 ? 21 
HELX_P HELX_P2 AA2 ARG A 54  ? LEU A 63  ? ARG A 34  LEU A 43  5 ? 10 
HELX_P HELX_P3 AA3 GLY A 86  ? PHE A 101 ? GLY A 66  PHE A 81  1 ? 16 
HELX_P HELX_P4 AA4 ASN A 163 ? LEU A 171 ? ASN A 143 LEU A 151 1 ? 9  
HELX_P HELX_P5 AA5 ARG B 34  ? HIS B 52  ? ARG B 14  HIS B 32  1 ? 19 
HELX_P HELX_P6 AA6 ARG B 54  ? LEU B 63  ? ARG B 34  LEU B 43  5 ? 10 
HELX_P HELX_P7 AA7 GLY B 86  ? PHE B 101 ? GLY B 66  PHE B 81  1 ? 16 
HELX_P HELX_P8 AA8 ASN B 163 ? LEU B 171 ? ASN B 143 LEU B 151 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 6 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 82  ? ARG A 85  ? ILE A 62  ARG A 65  
AA1 2 PHE A 65  ? LEU A 73  ? PHE A 45  LEU A 53  
AA1 3 LEU A 154 ? PHE A 161 ? LEU A 134 PHE A 141 
AA1 4 GLY A 138 ? GLU A 151 ? GLY A 118 GLU A 131 
AA1 5 TRP A 119 ? ILE A 130 ? TRP A 99  ILE A 110 
AA1 6 VAL A 105 ? GLU A 113 ? VAL A 85  GLU A 93  
AA2 1 ILE B 82  ? ARG B 85  ? ILE B 62  ARG B 65  
AA2 2 PHE B 65  ? LEU B 73  ? PHE B 45  LEU B 53  
AA2 3 LEU B 154 ? MET B 162 ? LEU B 134 MET B 142 
AA2 4 GLY B 138 ? GLU B 151 ? GLY B 118 GLU B 131 
AA2 5 TRP B 119 ? ILE B 130 ? TRP B 99  ILE B 110 
AA2 6 VAL B 105 ? PHE B 112 ? VAL B 85  PHE B 92  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ILE A 84  ? O ILE A 64  N GLY A 71  ? N GLY A 51  
AA1 2 3 N VAL A 70  ? N VAL A 50  O GLN A 158 ? O GLN A 138 
AA1 3 4 O LYS A 156 ? O LYS A 136 N ARG A 149 ? N ARG A 129 
AA1 4 5 O PHE A 144 ? O PHE A 124 N CYS A 124 ? N CYS A 104 
AA1 5 6 O TRP A 121 ? O TRP A 101 N PHE A 112 ? N PHE A 92  
AA2 1 2 O ILE B 84  ? O ILE B 64  N GLY B 71  ? N GLY B 51  
AA2 2 3 N VAL B 70  ? N VAL B 50  O GLN B 158 ? O GLN B 138 
AA2 3 4 O PHE B 161 ? O PHE B 141 N LEU B 145 ? N LEU B 125 
AA2 4 5 O PHE B 144 ? O PHE B 124 N CYS B 124 ? N CYS B 104 
AA2 5 6 O TRP B 121 ? O TRP B 101 N PHE B 112 ? N PHE B 92  
# 
_pdbx_entry_details.entry_id                   9F8K 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 HD1  B HIS 73  ? ? O B HOH 304 ? ? 1.59 
2 1 HH11 A ARG 117 ? ? O A HOH 305 ? ? 1.60 
3 1 O    B HOH 382 ? ? O B HOH 460 ? ? 1.94 
4 1 O    B HOH 428 ? ? O B HOH 447 ? ? 2.07 
5 1 O    A HOH 431 ? ? O A HOH 454 ? ? 2.08 
6 1 O    B HOH 309 ? ? O B HOH 337 ? ? 2.12 
7 1 O    B HOH 314 ? ? O B HOH 443 ? ? 2.17 
8 1 O    B HOH 428 ? ? O B HOH 442 ? ? 2.17 
9 1 O    A HOH 460 ? ? O A HOH 481 ? ? 2.18 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    ARG 
_pdbx_validate_torsion.auth_asym_id    B 
_pdbx_validate_torsion.auth_seq_id     160 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             -108.42 
_pdbx_validate_torsion.psi             74.93 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    B 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     485 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   J 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -19 ? A MET 1  
2  1 Y 1 A GLY -18 ? A GLY 2  
3  1 Y 1 A SER -17 ? A SER 3  
4  1 Y 1 A SER -16 ? A SER 4  
5  1 Y 1 A HIS -15 ? A HIS 5  
6  1 Y 1 A HIS -14 ? A HIS 6  
7  1 Y 1 A HIS -13 ? A HIS 7  
8  1 Y 1 A HIS -12 ? A HIS 8  
9  1 Y 1 A HIS -11 ? A HIS 9  
10 1 Y 1 A HIS -10 ? A HIS 10 
11 1 Y 1 A SER -9  ? A SER 11 
12 1 Y 1 A SER -8  ? A SER 12 
13 1 Y 1 A GLY -7  ? A GLY 13 
14 1 Y 1 A LEU -6  ? A LEU 14 
15 1 Y 1 A VAL -5  ? A VAL 15 
16 1 Y 1 A PRO -4  ? A PRO 16 
17 1 Y 1 A ARG -3  ? A ARG 17 
18 1 Y 1 A GLY -2  ? A GLY 18 
19 1 Y 1 A SER -1  ? A SER 19 
20 1 Y 1 A HIS 0   ? A HIS 20 
21 1 Y 1 A MET 1   ? A MET 21 
22 1 Y 1 A SER 2   ? A SER 22 
23 1 Y 1 A ASP 3   ? A ASP 23 
24 1 Y 1 A VAL 4   ? A VAL 24 
25 1 Y 1 A GLU 5   ? A GLU 25 
26 1 Y 1 A SER 6   ? A SER 26 
27 1 Y 1 A LEU 7   ? A LEU 27 
28 1 Y 1 A GLU 8   ? A GLU 28 
29 1 Y 1 A ASN 9   ? A ASN 29 
30 1 Y 1 A THR 10  ? A THR 30 
31 1 Y 1 A SER 11  ? A SER 31 
32 1 Y 1 B MET -19 ? B MET 1  
33 1 Y 1 B GLY -18 ? B GLY 2  
34 1 Y 1 B SER -17 ? B SER 3  
35 1 Y 1 B SER -16 ? B SER 4  
36 1 Y 1 B HIS -15 ? B HIS 5  
37 1 Y 1 B HIS -14 ? B HIS 6  
38 1 Y 1 B HIS -13 ? B HIS 7  
39 1 Y 1 B HIS -12 ? B HIS 8  
40 1 Y 1 B HIS -11 ? B HIS 9  
41 1 Y 1 B HIS -10 ? B HIS 10 
42 1 Y 1 B SER -9  ? B SER 11 
43 1 Y 1 B SER -8  ? B SER 12 
44 1 Y 1 B GLY -7  ? B GLY 13 
45 1 Y 1 B LEU -6  ? B LEU 14 
46 1 Y 1 B VAL -5  ? B VAL 15 
47 1 Y 1 B PRO -4  ? B PRO 16 
48 1 Y 1 B ARG -3  ? B ARG 17 
49 1 Y 1 B GLY -2  ? B GLY 18 
50 1 Y 1 B SER -1  ? B SER 19 
51 1 Y 1 B HIS 0   ? B HIS 20 
52 1 Y 1 B MET 1   ? B MET 21 
53 1 Y 1 B SER 2   ? B SER 22 
54 1 Y 1 B ASP 3   ? B ASP 23 
55 1 Y 1 B VAL 4   ? B VAL 24 
56 1 Y 1 B GLU 5   ? B GLU 25 
57 1 Y 1 B SER 6   ? B SER 26 
58 1 Y 1 B LEU 7   ? B LEU 27 
59 1 Y 1 B GLU 8   ? B GLU 28 
60 1 Y 1 B ASN 9   ? B ASN 29 
61 1 Y 1 B THR 10  ? B THR 30 
62 1 Y 1 B SER 11  ? B SER 31 
63 1 Y 1 B GLU 12  ? B GLU 32 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1IAH C1   C N N 1   
A1IAH C2   C N N 2   
A1IAH C3   C N N 3   
A1IAH C4   C Y N 4   
A1IAH C5   C Y N 5   
A1IAH C6   C Y N 6   
A1IAH C7   C Y N 7   
A1IAH C8   C Y N 8   
A1IAH C9   C N N 9   
A1IAH C10  C Y N 10  
A1IAH C11  C Y N 11  
A1IAH C12  C Y N 12  
A1IAH C13  C Y N 13  
A1IAH C14  C Y N 14  
A1IAH C15  C Y N 15  
A1IAH C16  C Y N 16  
A1IAH C17  C Y N 17  
A1IAH C18  C Y N 18  
A1IAH C19  C Y N 19  
A1IAH C20  C Y N 20  
A1IAH C21  C Y N 21  
A1IAH C22  C Y N 22  
A1IAH C23  C Y N 23  
A1IAH C24  C Y N 24  
A1IAH O1   O N N 25  
A1IAH O2   O N N 26  
A1IAH O3   O N N 27  
A1IAH S1   S Y N 28  
A1IAH H1   H N N 29  
A1IAH H2   H N N 30  
A1IAH H3   H N N 31  
A1IAH H4   H N N 32  
A1IAH H7   H N N 33  
A1IAH H6   H N N 34  
A1IAH H5   H N N 35  
A1IAH H8   H N N 36  
A1IAH H9   H N N 37  
A1IAH H10  H N N 38  
A1IAH H11  H N N 39  
A1IAH H12  H N N 40  
A1IAH H14  H N N 41  
A1IAH H15  H N N 42  
A1IAH H16  H N N 43  
A1IAH H18  H N N 44  
A1IAH H19  H N N 45  
A1IAH H20  H N N 46  
A1IAH H13  H N N 47  
A1IAH H17  H N N 48  
ACT   C    C N N 49  
ACT   O    O N N 50  
ACT   OXT  O N N 51  
ACT   CH3  C N N 52  
ACT   H1   H N N 53  
ACT   H2   H N N 54  
ACT   H3   H N N 55  
ALA   N    N N N 56  
ALA   CA   C N S 57  
ALA   C    C N N 58  
ALA   O    O N N 59  
ALA   CB   C N N 60  
ALA   OXT  O N N 61  
ALA   H    H N N 62  
ALA   H2   H N N 63  
ALA   HA   H N N 64  
ALA   HB1  H N N 65  
ALA   HB2  H N N 66  
ALA   HB3  H N N 67  
ALA   HXT  H N N 68  
ARG   N    N N N 69  
ARG   CA   C N S 70  
ARG   C    C N N 71  
ARG   O    O N N 72  
ARG   CB   C N N 73  
ARG   CG   C N N 74  
ARG   CD   C N N 75  
ARG   NE   N N N 76  
ARG   CZ   C N N 77  
ARG   NH1  N N N 78  
ARG   NH2  N N N 79  
ARG   OXT  O N N 80  
ARG   H    H N N 81  
ARG   H2   H N N 82  
ARG   HA   H N N 83  
ARG   HB2  H N N 84  
ARG   HB3  H N N 85  
ARG   HG2  H N N 86  
ARG   HG3  H N N 87  
ARG   HD2  H N N 88  
ARG   HD3  H N N 89  
ARG   HE   H N N 90  
ARG   HH11 H N N 91  
ARG   HH12 H N N 92  
ARG   HH21 H N N 93  
ARG   HH22 H N N 94  
ARG   HXT  H N N 95  
ASN   N    N N N 96  
ASN   CA   C N S 97  
ASN   C    C N N 98  
ASN   O    O N N 99  
ASN   CB   C N N 100 
ASN   CG   C N N 101 
ASN   OD1  O N N 102 
ASN   ND2  N N N 103 
ASN   OXT  O N N 104 
ASN   H    H N N 105 
ASN   H2   H N N 106 
ASN   HA   H N N 107 
ASN   HB2  H N N 108 
ASN   HB3  H N N 109 
ASN   HD21 H N N 110 
ASN   HD22 H N N 111 
ASN   HXT  H N N 112 
ASP   N    N N N 113 
ASP   CA   C N S 114 
ASP   C    C N N 115 
ASP   O    O N N 116 
ASP   CB   C N N 117 
ASP   CG   C N N 118 
ASP   OD1  O N N 119 
ASP   OD2  O N N 120 
ASP   OXT  O N N 121 
ASP   H    H N N 122 
ASP   H2   H N N 123 
ASP   HA   H N N 124 
ASP   HB2  H N N 125 
ASP   HB3  H N N 126 
ASP   HD2  H N N 127 
ASP   HXT  H N N 128 
CYS   N    N N N 129 
CYS   CA   C N R 130 
CYS   C    C N N 131 
CYS   O    O N N 132 
CYS   CB   C N N 133 
CYS   SG   S N N 134 
CYS   OXT  O N N 135 
CYS   H    H N N 136 
CYS   H2   H N N 137 
CYS   HA   H N N 138 
CYS   HB2  H N N 139 
CYS   HB3  H N N 140 
CYS   HG   H N N 141 
CYS   HXT  H N N 142 
GLN   N    N N N 143 
GLN   CA   C N S 144 
GLN   C    C N N 145 
GLN   O    O N N 146 
GLN   CB   C N N 147 
GLN   CG   C N N 148 
GLN   CD   C N N 149 
GLN   OE1  O N N 150 
GLN   NE2  N N N 151 
GLN   OXT  O N N 152 
GLN   H    H N N 153 
GLN   H2   H N N 154 
GLN   HA   H N N 155 
GLN   HB2  H N N 156 
GLN   HB3  H N N 157 
GLN   HG2  H N N 158 
GLN   HG3  H N N 159 
GLN   HE21 H N N 160 
GLN   HE22 H N N 161 
GLN   HXT  H N N 162 
GLU   N    N N N 163 
GLU   CA   C N S 164 
GLU   C    C N N 165 
GLU   O    O N N 166 
GLU   CB   C N N 167 
GLU   CG   C N N 168 
GLU   CD   C N N 169 
GLU   OE1  O N N 170 
GLU   OE2  O N N 171 
GLU   OXT  O N N 172 
GLU   H    H N N 173 
GLU   H2   H N N 174 
GLU   HA   H N N 175 
GLU   HB2  H N N 176 
GLU   HB3  H N N 177 
GLU   HG2  H N N 178 
GLU   HG3  H N N 179 
GLU   HE2  H N N 180 
GLU   HXT  H N N 181 
GLY   N    N N N 182 
GLY   CA   C N N 183 
GLY   C    C N N 184 
GLY   O    O N N 185 
GLY   OXT  O N N 186 
GLY   H    H N N 187 
GLY   H2   H N N 188 
GLY   HA2  H N N 189 
GLY   HA3  H N N 190 
GLY   HXT  H N N 191 
GOL   C1   C N N 192 
GOL   O1   O N N 193 
GOL   C2   C N N 194 
GOL   O2   O N N 195 
GOL   C3   C N N 196 
GOL   O3   O N N 197 
GOL   H11  H N N 198 
GOL   H12  H N N 199 
GOL   HO1  H N N 200 
GOL   H2   H N N 201 
GOL   HO2  H N N 202 
GOL   H31  H N N 203 
GOL   H32  H N N 204 
GOL   HO3  H N N 205 
HIS   N    N N N 206 
HIS   CA   C N S 207 
HIS   C    C N N 208 
HIS   O    O N N 209 
HIS   CB   C N N 210 
HIS   CG   C Y N 211 
HIS   ND1  N Y N 212 
HIS   CD2  C Y N 213 
HIS   CE1  C Y N 214 
HIS   NE2  N Y N 215 
HIS   OXT  O N N 216 
HIS   H    H N N 217 
HIS   H2   H N N 218 
HIS   HA   H N N 219 
HIS   HB2  H N N 220 
HIS   HB3  H N N 221 
HIS   HD1  H N N 222 
HIS   HD2  H N N 223 
HIS   HE1  H N N 224 
HIS   HE2  H N N 225 
HIS   HXT  H N N 226 
HOH   O    O N N 227 
HOH   H1   H N N 228 
HOH   H2   H N N 229 
ILE   N    N N N 230 
ILE   CA   C N S 231 
ILE   C    C N N 232 
ILE   O    O N N 233 
ILE   CB   C N S 234 
ILE   CG1  C N N 235 
ILE   CG2  C N N 236 
ILE   CD1  C N N 237 
ILE   OXT  O N N 238 
ILE   H    H N N 239 
ILE   H2   H N N 240 
ILE   HA   H N N 241 
ILE   HB   H N N 242 
ILE   HG12 H N N 243 
ILE   HG13 H N N 244 
ILE   HG21 H N N 245 
ILE   HG22 H N N 246 
ILE   HG23 H N N 247 
ILE   HD11 H N N 248 
ILE   HD12 H N N 249 
ILE   HD13 H N N 250 
ILE   HXT  H N N 251 
LEU   N    N N N 252 
LEU   CA   C N S 253 
LEU   C    C N N 254 
LEU   O    O N N 255 
LEU   CB   C N N 256 
LEU   CG   C N N 257 
LEU   CD1  C N N 258 
LEU   CD2  C N N 259 
LEU   OXT  O N N 260 
LEU   H    H N N 261 
LEU   H2   H N N 262 
LEU   HA   H N N 263 
LEU   HB2  H N N 264 
LEU   HB3  H N N 265 
LEU   HG   H N N 266 
LEU   HD11 H N N 267 
LEU   HD12 H N N 268 
LEU   HD13 H N N 269 
LEU   HD21 H N N 270 
LEU   HD22 H N N 271 
LEU   HD23 H N N 272 
LEU   HXT  H N N 273 
LYS   N    N N N 274 
LYS   CA   C N S 275 
LYS   C    C N N 276 
LYS   O    O N N 277 
LYS   CB   C N N 278 
LYS   CG   C N N 279 
LYS   CD   C N N 280 
LYS   CE   C N N 281 
LYS   NZ   N N N 282 
LYS   OXT  O N N 283 
LYS   H    H N N 284 
LYS   H2   H N N 285 
LYS   HA   H N N 286 
LYS   HB2  H N N 287 
LYS   HB3  H N N 288 
LYS   HG2  H N N 289 
LYS   HG3  H N N 290 
LYS   HD2  H N N 291 
LYS   HD3  H N N 292 
LYS   HE2  H N N 293 
LYS   HE3  H N N 294 
LYS   HZ1  H N N 295 
LYS   HZ2  H N N 296 
LYS   HZ3  H N N 297 
LYS   HXT  H N N 298 
MET   N    N N N 299 
MET   CA   C N S 300 
MET   C    C N N 301 
MET   O    O N N 302 
MET   CB   C N N 303 
MET   CG   C N N 304 
MET   SD   S N N 305 
MET   CE   C N N 306 
MET   OXT  O N N 307 
MET   H    H N N 308 
MET   H2   H N N 309 
MET   HA   H N N 310 
MET   HB2  H N N 311 
MET   HB3  H N N 312 
MET   HG2  H N N 313 
MET   HG3  H N N 314 
MET   HE1  H N N 315 
MET   HE2  H N N 316 
MET   HE3  H N N 317 
MET   HXT  H N N 318 
PHE   N    N N N 319 
PHE   CA   C N S 320 
PHE   C    C N N 321 
PHE   O    O N N 322 
PHE   CB   C N N 323 
PHE   CG   C Y N 324 
PHE   CD1  C Y N 325 
PHE   CD2  C Y N 326 
PHE   CE1  C Y N 327 
PHE   CE2  C Y N 328 
PHE   CZ   C Y N 329 
PHE   OXT  O N N 330 
PHE   H    H N N 331 
PHE   H2   H N N 332 
PHE   HA   H N N 333 
PHE   HB2  H N N 334 
PHE   HB3  H N N 335 
PHE   HD1  H N N 336 
PHE   HD2  H N N 337 
PHE   HE1  H N N 338 
PHE   HE2  H N N 339 
PHE   HZ   H N N 340 
PHE   HXT  H N N 341 
PRO   N    N N N 342 
PRO   CA   C N S 343 
PRO   C    C N N 344 
PRO   O    O N N 345 
PRO   CB   C N N 346 
PRO   CG   C N N 347 
PRO   CD   C N N 348 
PRO   OXT  O N N 349 
PRO   H    H N N 350 
PRO   HA   H N N 351 
PRO   HB2  H N N 352 
PRO   HB3  H N N 353 
PRO   HG2  H N N 354 
PRO   HG3  H N N 355 
PRO   HD2  H N N 356 
PRO   HD3  H N N 357 
PRO   HXT  H N N 358 
SER   N    N N N 359 
SER   CA   C N S 360 
SER   C    C N N 361 
SER   O    O N N 362 
SER   CB   C N N 363 
SER   OG   O N N 364 
SER   OXT  O N N 365 
SER   H    H N N 366 
SER   H2   H N N 367 
SER   HA   H N N 368 
SER   HB2  H N N 369 
SER   HB3  H N N 370 
SER   HG   H N N 371 
SER   HXT  H N N 372 
THR   N    N N N 373 
THR   CA   C N S 374 
THR   C    C N N 375 
THR   O    O N N 376 
THR   CB   C N R 377 
THR   OG1  O N N 378 
THR   CG2  C N N 379 
THR   OXT  O N N 380 
THR   H    H N N 381 
THR   H2   H N N 382 
THR   HA   H N N 383 
THR   HB   H N N 384 
THR   HG1  H N N 385 
THR   HG21 H N N 386 
THR   HG22 H N N 387 
THR   HG23 H N N 388 
THR   HXT  H N N 389 
TRP   N    N N N 390 
TRP   CA   C N S 391 
TRP   C    C N N 392 
TRP   O    O N N 393 
TRP   CB   C N N 394 
TRP   CG   C Y N 395 
TRP   CD1  C Y N 396 
TRP   CD2  C Y N 397 
TRP   NE1  N Y N 398 
TRP   CE2  C Y N 399 
TRP   CE3  C Y N 400 
TRP   CZ2  C Y N 401 
TRP   CZ3  C Y N 402 
TRP   CH2  C Y N 403 
TRP   OXT  O N N 404 
TRP   H    H N N 405 
TRP   H2   H N N 406 
TRP   HA   H N N 407 
TRP   HB2  H N N 408 
TRP   HB3  H N N 409 
TRP   HD1  H N N 410 
TRP   HE1  H N N 411 
TRP   HE3  H N N 412 
TRP   HZ2  H N N 413 
TRP   HZ3  H N N 414 
TRP   HH2  H N N 415 
TRP   HXT  H N N 416 
TYR   N    N N N 417 
TYR   CA   C N S 418 
TYR   C    C N N 419 
TYR   O    O N N 420 
TYR   CB   C N N 421 
TYR   CG   C Y N 422 
TYR   CD1  C Y N 423 
TYR   CD2  C Y N 424 
TYR   CE1  C Y N 425 
TYR   CE2  C Y N 426 
TYR   CZ   C Y N 427 
TYR   OH   O N N 428 
TYR   OXT  O N N 429 
TYR   H    H N N 430 
TYR   H2   H N N 431 
TYR   HA   H N N 432 
TYR   HB2  H N N 433 
TYR   HB3  H N N 434 
TYR   HD1  H N N 435 
TYR   HD2  H N N 436 
TYR   HE1  H N N 437 
TYR   HE2  H N N 438 
TYR   HH   H N N 439 
TYR   HXT  H N N 440 
VAL   N    N N N 441 
VAL   CA   C N S 442 
VAL   C    C N N 443 
VAL   O    O N N 444 
VAL   CB   C N N 445 
VAL   CG1  C N N 446 
VAL   CG2  C N N 447 
VAL   OXT  O N N 448 
VAL   H    H N N 449 
VAL   H2   H N N 450 
VAL   HA   H N N 451 
VAL   HB   H N N 452 
VAL   HG11 H N N 453 
VAL   HG12 H N N 454 
VAL   HG13 H N N 455 
VAL   HG21 H N N 456 
VAL   HG22 H N N 457 
VAL   HG23 H N N 458 
VAL   HXT  H N N 459 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1IAH C3  C2   sing N N 1   
A1IAH C1  C2   sing N N 2   
A1IAH C14 C13  doub Y N 3   
A1IAH C14 C15  sing Y N 4   
A1IAH C2  C4   sing N N 5   
A1IAH C13 C12  sing Y N 6   
A1IAH O2  C15  sing N N 7   
A1IAH C15 C16  doub Y N 8   
A1IAH S1  C11  sing Y N 9   
A1IAH S1  C18  sing Y N 10  
A1IAH C4  C24  doub Y N 11  
A1IAH C4  C5   sing Y N 12  
A1IAH C12 C11  sing N N 13  
A1IAH C12 C17  doub Y N 14  
A1IAH C19 C18  doub Y N 15  
A1IAH C19 C20  sing Y N 16  
A1IAH C24 C8   sing Y N 17  
A1IAH C11 C10  doub Y N 18  
A1IAH C16 C17  sing Y N 19  
A1IAH C18 C23  sing Y N 20  
A1IAH C5  C6   doub Y N 21  
A1IAH O3  C20  sing N N 22  
A1IAH C20 C21  doub Y N 23  
A1IAH C10 C23  sing Y N 24  
A1IAH C10 C9   sing N N 25  
A1IAH C23 C22  doub Y N 26  
A1IAH C8  C9   sing N N 27  
A1IAH C8  C7   doub Y N 28  
A1IAH C21 C22  sing Y N 29  
A1IAH C9  O1   doub N N 30  
A1IAH C6  C7   sing Y N 31  
A1IAH C1  H1   sing N N 32  
A1IAH C1  H2   sing N N 33  
A1IAH C1  H3   sing N N 34  
A1IAH C2  H4   sing N N 35  
A1IAH C3  H7   sing N N 36  
A1IAH C3  H6   sing N N 37  
A1IAH C3  H5   sing N N 38  
A1IAH C5  H8   sing N N 39  
A1IAH C6  H9   sing N N 40  
A1IAH C7  H10  sing N N 41  
A1IAH C13 H11  sing N N 42  
A1IAH C14 H12  sing N N 43  
A1IAH C16 H14  sing N N 44  
A1IAH C17 H15  sing N N 45  
A1IAH C19 H16  sing N N 46  
A1IAH C21 H18  sing N N 47  
A1IAH C22 H19  sing N N 48  
A1IAH C24 H20  sing N N 49  
A1IAH O2  H13  sing N N 50  
A1IAH O3  H17  sing N N 51  
ACT   C   O    doub N N 52  
ACT   C   OXT  sing N N 53  
ACT   C   CH3  sing N N 54  
ACT   CH3 H1   sing N N 55  
ACT   CH3 H2   sing N N 56  
ACT   CH3 H3   sing N N 57  
ALA   N   CA   sing N N 58  
ALA   N   H    sing N N 59  
ALA   N   H2   sing N N 60  
ALA   CA  C    sing N N 61  
ALA   CA  CB   sing N N 62  
ALA   CA  HA   sing N N 63  
ALA   C   O    doub N N 64  
ALA   C   OXT  sing N N 65  
ALA   CB  HB1  sing N N 66  
ALA   CB  HB2  sing N N 67  
ALA   CB  HB3  sing N N 68  
ALA   OXT HXT  sing N N 69  
ARG   N   CA   sing N N 70  
ARG   N   H    sing N N 71  
ARG   N   H2   sing N N 72  
ARG   CA  C    sing N N 73  
ARG   CA  CB   sing N N 74  
ARG   CA  HA   sing N N 75  
ARG   C   O    doub N N 76  
ARG   C   OXT  sing N N 77  
ARG   CB  CG   sing N N 78  
ARG   CB  HB2  sing N N 79  
ARG   CB  HB3  sing N N 80  
ARG   CG  CD   sing N N 81  
ARG   CG  HG2  sing N N 82  
ARG   CG  HG3  sing N N 83  
ARG   CD  NE   sing N N 84  
ARG   CD  HD2  sing N N 85  
ARG   CD  HD3  sing N N 86  
ARG   NE  CZ   sing N N 87  
ARG   NE  HE   sing N N 88  
ARG   CZ  NH1  sing N N 89  
ARG   CZ  NH2  doub N N 90  
ARG   NH1 HH11 sing N N 91  
ARG   NH1 HH12 sing N N 92  
ARG   NH2 HH21 sing N N 93  
ARG   NH2 HH22 sing N N 94  
ARG   OXT HXT  sing N N 95  
ASN   N   CA   sing N N 96  
ASN   N   H    sing N N 97  
ASN   N   H2   sing N N 98  
ASN   CA  C    sing N N 99  
ASN   CA  CB   sing N N 100 
ASN   CA  HA   sing N N 101 
ASN   C   O    doub N N 102 
ASN   C   OXT  sing N N 103 
ASN   CB  CG   sing N N 104 
ASN   CB  HB2  sing N N 105 
ASN   CB  HB3  sing N N 106 
ASN   CG  OD1  doub N N 107 
ASN   CG  ND2  sing N N 108 
ASN   ND2 HD21 sing N N 109 
ASN   ND2 HD22 sing N N 110 
ASN   OXT HXT  sing N N 111 
ASP   N   CA   sing N N 112 
ASP   N   H    sing N N 113 
ASP   N   H2   sing N N 114 
ASP   CA  C    sing N N 115 
ASP   CA  CB   sing N N 116 
ASP   CA  HA   sing N N 117 
ASP   C   O    doub N N 118 
ASP   C   OXT  sing N N 119 
ASP   CB  CG   sing N N 120 
ASP   CB  HB2  sing N N 121 
ASP   CB  HB3  sing N N 122 
ASP   CG  OD1  doub N N 123 
ASP   CG  OD2  sing N N 124 
ASP   OD2 HD2  sing N N 125 
ASP   OXT HXT  sing N N 126 
CYS   N   CA   sing N N 127 
CYS   N   H    sing N N 128 
CYS   N   H2   sing N N 129 
CYS   CA  C    sing N N 130 
CYS   CA  CB   sing N N 131 
CYS   CA  HA   sing N N 132 
CYS   C   O    doub N N 133 
CYS   C   OXT  sing N N 134 
CYS   CB  SG   sing N N 135 
CYS   CB  HB2  sing N N 136 
CYS   CB  HB3  sing N N 137 
CYS   SG  HG   sing N N 138 
CYS   OXT HXT  sing N N 139 
GLN   N   CA   sing N N 140 
GLN   N   H    sing N N 141 
GLN   N   H2   sing N N 142 
GLN   CA  C    sing N N 143 
GLN   CA  CB   sing N N 144 
GLN   CA  HA   sing N N 145 
GLN   C   O    doub N N 146 
GLN   C   OXT  sing N N 147 
GLN   CB  CG   sing N N 148 
GLN   CB  HB2  sing N N 149 
GLN   CB  HB3  sing N N 150 
GLN   CG  CD   sing N N 151 
GLN   CG  HG2  sing N N 152 
GLN   CG  HG3  sing N N 153 
GLN   CD  OE1  doub N N 154 
GLN   CD  NE2  sing N N 155 
GLN   NE2 HE21 sing N N 156 
GLN   NE2 HE22 sing N N 157 
GLN   OXT HXT  sing N N 158 
GLU   N   CA   sing N N 159 
GLU   N   H    sing N N 160 
GLU   N   H2   sing N N 161 
GLU   CA  C    sing N N 162 
GLU   CA  CB   sing N N 163 
GLU   CA  HA   sing N N 164 
GLU   C   O    doub N N 165 
GLU   C   OXT  sing N N 166 
GLU   CB  CG   sing N N 167 
GLU   CB  HB2  sing N N 168 
GLU   CB  HB3  sing N N 169 
GLU   CG  CD   sing N N 170 
GLU   CG  HG2  sing N N 171 
GLU   CG  HG3  sing N N 172 
GLU   CD  OE1  doub N N 173 
GLU   CD  OE2  sing N N 174 
GLU   OE2 HE2  sing N N 175 
GLU   OXT HXT  sing N N 176 
GLY   N   CA   sing N N 177 
GLY   N   H    sing N N 178 
GLY   N   H2   sing N N 179 
GLY   CA  C    sing N N 180 
GLY   CA  HA2  sing N N 181 
GLY   CA  HA3  sing N N 182 
GLY   C   O    doub N N 183 
GLY   C   OXT  sing N N 184 
GLY   OXT HXT  sing N N 185 
GOL   C1  O1   sing N N 186 
GOL   C1  C2   sing N N 187 
GOL   C1  H11  sing N N 188 
GOL   C1  H12  sing N N 189 
GOL   O1  HO1  sing N N 190 
GOL   C2  O2   sing N N 191 
GOL   C2  C3   sing N N 192 
GOL   C2  H2   sing N N 193 
GOL   O2  HO2  sing N N 194 
GOL   C3  O3   sing N N 195 
GOL   C3  H31  sing N N 196 
GOL   C3  H32  sing N N 197 
GOL   O3  HO3  sing N N 198 
HIS   N   CA   sing N N 199 
HIS   N   H    sing N N 200 
HIS   N   H2   sing N N 201 
HIS   CA  C    sing N N 202 
HIS   CA  CB   sing N N 203 
HIS   CA  HA   sing N N 204 
HIS   C   O    doub N N 205 
HIS   C   OXT  sing N N 206 
HIS   CB  CG   sing N N 207 
HIS   CB  HB2  sing N N 208 
HIS   CB  HB3  sing N N 209 
HIS   CG  ND1  sing Y N 210 
HIS   CG  CD2  doub Y N 211 
HIS   ND1 CE1  doub Y N 212 
HIS   ND1 HD1  sing N N 213 
HIS   CD2 NE2  sing Y N 214 
HIS   CD2 HD2  sing N N 215 
HIS   CE1 NE2  sing Y N 216 
HIS   CE1 HE1  sing N N 217 
HIS   NE2 HE2  sing N N 218 
HIS   OXT HXT  sing N N 219 
HOH   O   H1   sing N N 220 
HOH   O   H2   sing N N 221 
ILE   N   CA   sing N N 222 
ILE   N   H    sing N N 223 
ILE   N   H2   sing N N 224 
ILE   CA  C    sing N N 225 
ILE   CA  CB   sing N N 226 
ILE   CA  HA   sing N N 227 
ILE   C   O    doub N N 228 
ILE   C   OXT  sing N N 229 
ILE   CB  CG1  sing N N 230 
ILE   CB  CG2  sing N N 231 
ILE   CB  HB   sing N N 232 
ILE   CG1 CD1  sing N N 233 
ILE   CG1 HG12 sing N N 234 
ILE   CG1 HG13 sing N N 235 
ILE   CG2 HG21 sing N N 236 
ILE   CG2 HG22 sing N N 237 
ILE   CG2 HG23 sing N N 238 
ILE   CD1 HD11 sing N N 239 
ILE   CD1 HD12 sing N N 240 
ILE   CD1 HD13 sing N N 241 
ILE   OXT HXT  sing N N 242 
LEU   N   CA   sing N N 243 
LEU   N   H    sing N N 244 
LEU   N   H2   sing N N 245 
LEU   CA  C    sing N N 246 
LEU   CA  CB   sing N N 247 
LEU   CA  HA   sing N N 248 
LEU   C   O    doub N N 249 
LEU   C   OXT  sing N N 250 
LEU   CB  CG   sing N N 251 
LEU   CB  HB2  sing N N 252 
LEU   CB  HB3  sing N N 253 
LEU   CG  CD1  sing N N 254 
LEU   CG  CD2  sing N N 255 
LEU   CG  HG   sing N N 256 
LEU   CD1 HD11 sing N N 257 
LEU   CD1 HD12 sing N N 258 
LEU   CD1 HD13 sing N N 259 
LEU   CD2 HD21 sing N N 260 
LEU   CD2 HD22 sing N N 261 
LEU   CD2 HD23 sing N N 262 
LEU   OXT HXT  sing N N 263 
LYS   N   CA   sing N N 264 
LYS   N   H    sing N N 265 
LYS   N   H2   sing N N 266 
LYS   CA  C    sing N N 267 
LYS   CA  CB   sing N N 268 
LYS   CA  HA   sing N N 269 
LYS   C   O    doub N N 270 
LYS   C   OXT  sing N N 271 
LYS   CB  CG   sing N N 272 
LYS   CB  HB2  sing N N 273 
LYS   CB  HB3  sing N N 274 
LYS   CG  CD   sing N N 275 
LYS   CG  HG2  sing N N 276 
LYS   CG  HG3  sing N N 277 
LYS   CD  CE   sing N N 278 
LYS   CD  HD2  sing N N 279 
LYS   CD  HD3  sing N N 280 
LYS   CE  NZ   sing N N 281 
LYS   CE  HE2  sing N N 282 
LYS   CE  HE3  sing N N 283 
LYS   NZ  HZ1  sing N N 284 
LYS   NZ  HZ2  sing N N 285 
LYS   NZ  HZ3  sing N N 286 
LYS   OXT HXT  sing N N 287 
MET   N   CA   sing N N 288 
MET   N   H    sing N N 289 
MET   N   H2   sing N N 290 
MET   CA  C    sing N N 291 
MET   CA  CB   sing N N 292 
MET   CA  HA   sing N N 293 
MET   C   O    doub N N 294 
MET   C   OXT  sing N N 295 
MET   CB  CG   sing N N 296 
MET   CB  HB2  sing N N 297 
MET   CB  HB3  sing N N 298 
MET   CG  SD   sing N N 299 
MET   CG  HG2  sing N N 300 
MET   CG  HG3  sing N N 301 
MET   SD  CE   sing N N 302 
MET   CE  HE1  sing N N 303 
MET   CE  HE2  sing N N 304 
MET   CE  HE3  sing N N 305 
MET   OXT HXT  sing N N 306 
PHE   N   CA   sing N N 307 
PHE   N   H    sing N N 308 
PHE   N   H2   sing N N 309 
PHE   CA  C    sing N N 310 
PHE   CA  CB   sing N N 311 
PHE   CA  HA   sing N N 312 
PHE   C   O    doub N N 313 
PHE   C   OXT  sing N N 314 
PHE   CB  CG   sing N N 315 
PHE   CB  HB2  sing N N 316 
PHE   CB  HB3  sing N N 317 
PHE   CG  CD1  doub Y N 318 
PHE   CG  CD2  sing Y N 319 
PHE   CD1 CE1  sing Y N 320 
PHE   CD1 HD1  sing N N 321 
PHE   CD2 CE2  doub Y N 322 
PHE   CD2 HD2  sing N N 323 
PHE   CE1 CZ   doub Y N 324 
PHE   CE1 HE1  sing N N 325 
PHE   CE2 CZ   sing Y N 326 
PHE   CE2 HE2  sing N N 327 
PHE   CZ  HZ   sing N N 328 
PHE   OXT HXT  sing N N 329 
PRO   N   CA   sing N N 330 
PRO   N   CD   sing N N 331 
PRO   N   H    sing N N 332 
PRO   CA  C    sing N N 333 
PRO   CA  CB   sing N N 334 
PRO   CA  HA   sing N N 335 
PRO   C   O    doub N N 336 
PRO   C   OXT  sing N N 337 
PRO   CB  CG   sing N N 338 
PRO   CB  HB2  sing N N 339 
PRO   CB  HB3  sing N N 340 
PRO   CG  CD   sing N N 341 
PRO   CG  HG2  sing N N 342 
PRO   CG  HG3  sing N N 343 
PRO   CD  HD2  sing N N 344 
PRO   CD  HD3  sing N N 345 
PRO   OXT HXT  sing N N 346 
SER   N   CA   sing N N 347 
SER   N   H    sing N N 348 
SER   N   H2   sing N N 349 
SER   CA  C    sing N N 350 
SER   CA  CB   sing N N 351 
SER   CA  HA   sing N N 352 
SER   C   O    doub N N 353 
SER   C   OXT  sing N N 354 
SER   CB  OG   sing N N 355 
SER   CB  HB2  sing N N 356 
SER   CB  HB3  sing N N 357 
SER   OG  HG   sing N N 358 
SER   OXT HXT  sing N N 359 
THR   N   CA   sing N N 360 
THR   N   H    sing N N 361 
THR   N   H2   sing N N 362 
THR   CA  C    sing N N 363 
THR   CA  CB   sing N N 364 
THR   CA  HA   sing N N 365 
THR   C   O    doub N N 366 
THR   C   OXT  sing N N 367 
THR   CB  OG1  sing N N 368 
THR   CB  CG2  sing N N 369 
THR   CB  HB   sing N N 370 
THR   OG1 HG1  sing N N 371 
THR   CG2 HG21 sing N N 372 
THR   CG2 HG22 sing N N 373 
THR   CG2 HG23 sing N N 374 
THR   OXT HXT  sing N N 375 
TRP   N   CA   sing N N 376 
TRP   N   H    sing N N 377 
TRP   N   H2   sing N N 378 
TRP   CA  C    sing N N 379 
TRP   CA  CB   sing N N 380 
TRP   CA  HA   sing N N 381 
TRP   C   O    doub N N 382 
TRP   C   OXT  sing N N 383 
TRP   CB  CG   sing N N 384 
TRP   CB  HB2  sing N N 385 
TRP   CB  HB3  sing N N 386 
TRP   CG  CD1  doub Y N 387 
TRP   CG  CD2  sing Y N 388 
TRP   CD1 NE1  sing Y N 389 
TRP   CD1 HD1  sing N N 390 
TRP   CD2 CE2  doub Y N 391 
TRP   CD2 CE3  sing Y N 392 
TRP   NE1 CE2  sing Y N 393 
TRP   NE1 HE1  sing N N 394 
TRP   CE2 CZ2  sing Y N 395 
TRP   CE3 CZ3  doub Y N 396 
TRP   CE3 HE3  sing N N 397 
TRP   CZ2 CH2  doub Y N 398 
TRP   CZ2 HZ2  sing N N 399 
TRP   CZ3 CH2  sing Y N 400 
TRP   CZ3 HZ3  sing N N 401 
TRP   CH2 HH2  sing N N 402 
TRP   OXT HXT  sing N N 403 
TYR   N   CA   sing N N 404 
TYR   N   H    sing N N 405 
TYR   N   H2   sing N N 406 
TYR   CA  C    sing N N 407 
TYR   CA  CB   sing N N 408 
TYR   CA  HA   sing N N 409 
TYR   C   O    doub N N 410 
TYR   C   OXT  sing N N 411 
TYR   CB  CG   sing N N 412 
TYR   CB  HB2  sing N N 413 
TYR   CB  HB3  sing N N 414 
TYR   CG  CD1  doub Y N 415 
TYR   CG  CD2  sing Y N 416 
TYR   CD1 CE1  sing Y N 417 
TYR   CD1 HD1  sing N N 418 
TYR   CD2 CE2  doub Y N 419 
TYR   CD2 HD2  sing N N 420 
TYR   CE1 CZ   doub Y N 421 
TYR   CE1 HE1  sing N N 422 
TYR   CE2 CZ   sing Y N 423 
TYR   CE2 HE2  sing N N 424 
TYR   CZ  OH   sing N N 425 
TYR   OH  HH   sing N N 426 
TYR   OXT HXT  sing N N 427 
VAL   N   CA   sing N N 428 
VAL   N   H    sing N N 429 
VAL   N   H2   sing N N 430 
VAL   CA  C    sing N N 431 
VAL   CA  CB   sing N N 432 
VAL   CA  HA   sing N N 433 
VAL   C   O    doub N N 434 
VAL   C   OXT  sing N N 435 
VAL   CB  CG1  sing N N 436 
VAL   CB  CG2  sing N N 437 
VAL   CB  HB   sing N N 438 
VAL   CG1 HG11 sing N N 439 
VAL   CG1 HG12 sing N N 440 
VAL   CG1 HG13 sing N N 441 
VAL   CG2 HG21 sing N N 442 
VAL   CG2 HG22 sing N N 443 
VAL   CG2 HG23 sing N N 444 
VAL   OXT HXT  sing N N 445 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3B4O 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9F8K 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014013 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002072 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012610 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.015779 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . GLU   A 1 32  ? 2.270  -0.339  20.621 1.00 76.06 ? 12  GLU   A N    1 
ATOM   2    C CA   . GLU   A 1 32  ? 3.635  -0.813  20.968 1.00 66.82 ? 12  GLU   A CA   1 
ATOM   3    C C    . GLU   A 1 32  ? 4.362  -1.151  19.665 1.00 57.02 ? 12  GLU   A C    1 
ATOM   4    O O    . GLU   A 1 32  ? 5.458  -0.663  19.480 1.00 45.25 ? 12  GLU   A O    1 
ATOM   5    C CB   . GLU   A 1 32  ? 3.606  -2.015  21.914 1.00 44.56 ? 12  GLU   A CB   1 
ATOM   6    H H    . GLU   A 1 32  ? 1.728  -1.044  20.472 1.00 91.28 ? 12  GLU   A H    1 
ATOM   7    H HA   . GLU   A 1 32  ? 4.117  -0.069  21.411 1.00 80.20 ? 12  GLU   A HA   1 
ATOM   8    N N    . ASN   A 1 33  ? 3.734  -1.923  18.788 1.00 53.48 ? 13  ASN   A N    1 
ATOM   9    C CA   . ASN   A 1 33  ? 4.344  -2.286  17.488 1.00 59.99 ? 13  ASN   A CA   1 
ATOM   10   C C    . ASN   A 1 33  ? 4.521  -1.030  16.634 1.00 52.92 ? 13  ASN   A C    1 
ATOM   11   O O    . ASN   A 1 33  ? 5.530  -0.940  15.975 1.00 45.53 ? 13  ASN   A O    1 
ATOM   12   C CB   . ASN   A 1 33  ? 3.522  -3.324  16.743 1.00 56.99 ? 13  ASN   A CB   1 
ATOM   13   H H    . ASN   A 1 33  ? 2.908  -2.246  18.950 1.00 64.19 ? 13  ASN   A H    1 
ATOM   14   H HA   . ASN   A 1 33  ? 5.232  -2.675  17.660 1.00 72.00 ? 13  ASN   A HA   1 
ATOM   15   N N    . ARG   A 1 34  ? 3.533  -0.144  16.602 1.00 50.70 ? 14  ARG   A N    1 
ATOM   16   C CA   . ARG   A 1 34  ? 3.593  1.068   15.753 1.00 50.47 ? 14  ARG   A CA   1 
ATOM   17   C C    . ARG   A 1 34  ? 4.689  1.996   16.282 1.00 35.83 ? 14  ARG   A C    1 
ATOM   18   O O    . ARG   A 1 34  ? 5.302  2.665   15.480 1.00 34.45 ? 14  ARG   A O    1 
ATOM   19   C CB   . ARG   A 1 34  ? 2.251  1.811   15.763 1.00 46.70 ? 14  ARG   A CB   1 
ATOM   20   H H    . ARG   A 1 34  ? 2.794  -0.244  17.110 1.00 60.86 ? 14  ARG   A H    1 
ATOM   21   H HA   . ARG   A 1 34  ? 3.818  0.797   14.827 1.00 60.57 ? 14  ARG   A HA   1 
ATOM   22   N N    . ALA   A 1 35  ? 4.880  2.056   17.596 1.00 38.18 ? 15  ALA   A N    1 
ATOM   23   C CA   . ALA   A 1 35  ? 5.927  2.899   18.163 1.00 33.65 ? 15  ALA   A CA   1 
ATOM   24   C C    . ALA   A 1 35  ? 7.312  2.353   17.844 1.00 35.54 ? 15  ALA   A C    1 
ATOM   25   O O    . ALA   A 1 35  ? 8.248  3.122   17.593 1.00 30.14 ? 15  ALA   A O    1 
ATOM   26   C CB   . ALA   A 1 35  ? 5.742  3.021   19.675 1.00 40.06 ? 15  ALA   A CB   1 
ATOM   27   H H    . ALA   A 1 35  ? 4.413  1.625   18.176 1.00 45.83 ? 15  ALA   A H    1 
ATOM   28   H HA   . ALA   A 1 35  ? 5.854  3.786   17.776 1.00 40.40 ? 15  ALA   A HA   1 
ATOM   29   H HB1  . ALA   A 1 35  ? 6.429  3.606   20.031 1.00 48.09 ? 15  ALA   A HB1  1 
ATOM   30   H HB2  . ALA   A 1 35  ? 4.865  3.393   19.857 1.00 48.09 ? 15  ALA   A HB2  1 
ATOM   31   H HB3  . ALA   A 1 35  ? 5.818  2.140   20.074 1.00 48.09 ? 15  ALA   A HB3  1 
ATOM   32   N N    . GLN   A 1 36  ? 7.466  1.028   17.865 1.00 36.57 ? 16  GLN   A N    1 
ATOM   33   C CA   . GLN   A 1 36  ? 8.759  0.436   17.541 1.00 40.00 ? 16  GLN   A CA   1 
ATOM   34   C C    . GLN   A 1 36  ? 9.107  0.653   16.077 1.00 30.11 ? 16  GLN   A C    1 
ATOM   35   O O    . GLN   A 1 36  ? 10.253 0.973   15.743 1.00 30.22 ? 16  GLN   A O    1 
ATOM   36   C CB   . GLN   A 1 36  ? 8.758  -1.058  17.866 1.00 37.66 ? 16  GLN   A CB   1 
ATOM   37   C CG   . GLN   A 1 36  ? 8.746  -1.369  19.347 1.00 44.92 ? 16  GLN   A CG   1 
ATOM   38   C CD   . GLN   A 1 36  ? 9.062  -2.819  19.632 1.00 65.49 ? 16  GLN   A CD   1 
ATOM   39   O OE1  . GLN   A 1 36  ? 9.218  -3.623  18.714 1.00 60.57 ? 16  GLN   A OE1  1 
ATOM   40   N NE2  . GLN   A 1 36  ? 9.163  -3.162  20.909 1.00 58.63 ? 16  GLN   A NE2  1 
ATOM   41   H H    . GLN   A 1 36  ? 6.849  0.462   18.060 1.00 43.90 ? 16  GLN   A H    1 
ATOM   42   H HA   . GLN   A 1 36  ? 9.438  0.861   18.088 1.00 48.01 ? 16  GLN   A HA   1 
ATOM   43   H HB2  . GLN   A 1 36  ? 7.968  -1.460  17.474 1.00 45.20 ? 16  GLN   A HB2  1 
ATOM   44   H HB3  . GLN   A 1 36  ? 9.557  -1.458  17.488 1.00 45.20 ? 16  GLN   A HB3  1 
ATOM   45   H HG2  . GLN   A 1 36  ? 9.412  -0.822  19.793 1.00 53.92 ? 16  GLN   A HG2  1 
ATOM   46   H HG3  . GLN   A 1 36  ? 7.865  -1.176  19.705 1.00 53.92 ? 16  GLN   A HG3  1 
ATOM   47   H HE21 . GLN   A 1 36  ? 9.050  -2.571  21.523 1.00 70.36 ? 16  GLN   A HE21 1 
ATOM   48   H HE22 . GLN   A 1 36  ? 9.341  -3.975  21.123 1.00 70.36 ? 16  GLN   A HE22 1 
ATOM   49   N N    . VAL   A 1 37  ? 8.132  0.481   15.188 1.00 25.94 ? 17  VAL   A N    1 
ATOM   50   C CA   . VAL   A 1 37  ? 8.380  0.696   13.766 1.00 31.80 ? 17  VAL   A CA   1 
ATOM   51   C C    . VAL   A 1 37  ? 8.768  2.146   13.510 1.00 41.31 ? 17  VAL   A C    1 
ATOM   52   O O    . VAL   A 1 37  ? 9.688  2.431   12.734 1.00 31.85 ? 17  VAL   A O    1 
ATOM   53   C CB   . VAL   A 1 37  ? 7.145  0.293   12.939 1.00 44.98 ? 17  VAL   A CB   1 
ATOM   54   C CG1  . VAL   A 1 37  ? 7.271  0.845   11.529 1.00 37.16 ? 17  VAL   A CG1  1 
ATOM   55   C CG2  . VAL   A 1 37  ? 6.975  -1.216  12.917 1.00 46.54 ? 17  VAL   A CG2  1 
ATOM   56   H H    . VAL   A 1 37  ? 7.328  0.243   15.379 1.00 31.14 ? 17  VAL   A H    1 
ATOM   57   H HA   . VAL   A 1 37  ? 9.121  0.131   13.497 1.00 38.18 ? 17  VAL   A HA   1 
ATOM   58   H HB   . VAL   A 1 37  ? 6.349  0.667   13.349 1.00 53.99 ? 17  VAL   A HB   1 
ATOM   59   H HG11 . VAL   A 1 37  ? 6.686  0.344   10.940 1.00 44.61 ? 17  VAL   A HG11 1 
ATOM   60   H HG12 . VAL   A 1 37  ? 7.016  1.781   11.532 1.00 44.61 ? 17  VAL   A HG12 1 
ATOM   61   H HG13 . VAL   A 1 37  ? 8.192  0.754   11.236 1.00 44.61 ? 17  VAL   A HG13 1 
ATOM   62   H HG21 . VAL   A 1 37  ? 6.199  -1.438  12.379 1.00 55.87 ? 17  VAL   A HG21 1 
ATOM   63   H HG22 . VAL   A 1 37  ? 7.770  -1.617  12.532 1.00 55.87 ? 17  VAL   A HG22 1 
ATOM   64   H HG23 . VAL   A 1 37  ? 6.851  -1.533  13.825 1.00 55.87 ? 17  VAL   A HG23 1 
ATOM   65   N N    . ALA   A 1 38  ? 8.065  3.085   14.147 1.00 34.98 ? 18  ALA   A N    1 
ATOM   66   C CA   . ALA   A 1 38  ? 8.381  4.499   13.975 1.00 25.86 ? 18  ALA   A CA   1 
ATOM   67   C C    . ALA   A 1 38  ? 9.817  4.791   14.392 1.00 22.95 ? 18  ALA   A C    1 
ATOM   68   O O    . ALA   A 1 38  ? 10.554 5.493   13.691 1.00 29.27 ? 18  ALA   A O    1 
ATOM   69   C CB   . ALA   A 1 38  ? 7.411  5.356   14.792 1.00 31.77 ? 18  ALA   A CB   1 
ATOM   70   H H    . ALA   A 1 38  ? 7.407  2.930   14.678 1.00 41.99 ? 18  ALA   A H    1 
ATOM   71   H HA   . ALA   A 1 38  ? 8.280  4.729   13.038 1.00 31.04 ? 18  ALA   A HA   1 
ATOM   72   H HB1  . ALA   A 1 38  ? 7.606  6.292   14.633 1.00 38.14 ? 18  ALA   A HB1  1 
ATOM   73   H HB2  . ALA   A 1 38  ? 6.503  5.155   14.515 1.00 38.14 ? 18  ALA   A HB2  1 
ATOM   74   H HB3  . ALA   A 1 38  ? 7.523  5.149   15.733 1.00 38.14 ? 18  ALA   A HB3  1 
ATOM   75   N N    . ALA   A 1 39  ? 10.225 4.261   15.544 1.00 27.81 ? 19  ALA   A N    1 
ATOM   76   C CA   . ALA   A 1 39  ? 11.568 4.518   16.049 1.00 28.35 ? 19  ALA   A CA   1 
ATOM   77   C C    . ALA   A 1 39  ? 12.618 3.954   15.102 1.00 28.71 ? 19  ALA   A C    1 
ATOM   78   O O    . ALA   A 1 39  ? 13.569 4.646   14.718 1.00 24.17 ? 19  ALA   A O    1 
ATOM   79   C CB   . ALA   A 1 39  ? 11.721 3.916   17.446 1.00 25.86 ? 19  ALA   A CB   1 
ATOM   80   H H    . ALA   A 1 39  ? 9.747  3.754   16.048 1.00 33.38 ? 19  ALA   A H    1 
ATOM   81   H HA   . ALA   A 1 39  ? 11.705 5.476   16.117 1.00 34.03 ? 19  ALA   A HA   1 
ATOM   82   H HB1  . ALA   A 1 39  ? 12.637 4.036   17.743 1.00 31.05 ? 19  ALA   A HB1  1 
ATOM   83   H HB2  . ALA   A 1 39  ? 11.115 4.369   18.053 1.00 31.05 ? 19  ALA   A HB2  1 
ATOM   84   H HB3  . ALA   A 1 39  ? 11.506 2.971   17.408 1.00 31.05 ? 19  ALA   A HB3  1 
ATOM   85   N N    . ARG   A 1 40  ? 12.450 2.693   14.699 1.00 26.11 ? 20  ARG   A N    1 
ATOM   86   C CA   . ARG   A 1 40  ? 13.443 2.055   13.841 1.00 24.66 ? 20  ARG   A CA   1 
ATOM   87   C C    . ARG   A 1 40  ? 13.607 2.803   12.526 1.00 23.18 ? 20  ARG   A C    1 
ATOM   88   O O    . ARG   A 1 40  ? 14.728 2.980   12.035 1.00 23.79 ? 20  ARG   A O    1 
ATOM   89   C CB   . ARG   A 1 40  ? 13.049 0.598   13.587 1.00 24.84 ? 20  ARG   A CB   1 
ATOM   90   C CG   . ARG   A 1 40  ? 14.090 -0.186  12.814 1.00 24.72 ? 20  ARG   A CG   1 
ATOM   91   C CD   . ARG   A 1 40  ? 13.639 -1.619  12.580 1.00 23.66 ? 20  ARG   A CD   1 
ATOM   92   N NE   . ARG   A 1 40  ? 13.698 -2.422  13.791 1.00 22.36 ? 20  ARG   A NE   1 
ATOM   93   C CZ   . ARG   A 1 40  ? 12.642 -2.781  14.507 1.00 23.66 ? 20  ARG   A CZ   1 
ATOM   94   N NH1  . ARG   A 1 40  ? 11.414 -2.456  14.138 1.00 27.34 ? 20  ARG   A NH1  1 
ATOM   95   N NH2  . ARG   A 1 40  ? 12.820 -3.483  15.619 1.00 22.64 ? 20  ARG   A NH2  1 
ATOM   96   H H    . ARG   A 1 40  ? 11.781 2.194   14.906 1.00 31.35 ? 20  ARG   A H    1 
ATOM   97   H HA   . ARG   A 1 40  ? 14.301 2.063   14.295 1.00 29.60 ? 20  ARG   A HA   1 
ATOM   98   H HB2  . ARG   A 1 40  ? 12.918 0.156   14.440 1.00 29.82 ? 20  ARG   A HB2  1 
ATOM   99   H HB3  . ARG   A 1 40  ? 12.225 0.582   13.075 1.00 29.82 ? 20  ARG   A HB3  1 
ATOM   100  H HG2  . ARG   A 1 40  ? 14.236 0.234   11.952 1.00 29.68 ? 20  ARG   A HG2  1 
ATOM   101  H HG3  . ARG   A 1 40  ? 14.919 -0.205  13.318 1.00 29.68 ? 20  ARG   A HG3  1 
ATOM   102  H HD2  . ARG   A 1 40  ? 12.721 -1.615  12.265 1.00 28.41 ? 20  ARG   A HD2  1 
ATOM   103  H HD3  . ARG   A 1 40  ? 14.216 -2.029  11.917 1.00 28.41 ? 20  ARG   A HD3  1 
ATOM   104  H HE   . ARG   A 1 40  ? 14.472 -2.683  14.061 1.00 26.84 ? 20  ARG   A HE   1 
ATOM   105  H HH11 . ARG   A 1 40  ? 11.287 -2.003  13.418 1.00 32.82 ? 20  ARG   A HH11 1 
ATOM   106  H HH12 . ARG   A 1 40  ? 10.742 -2.699  14.617 1.00 32.82 ? 20  ARG   A HH12 1 
ATOM   107  H HH21 . ARG   A 1 40  ? 13.614 -3.701  15.867 1.00 27.18 ? 20  ARG   A HH21 1 
ATOM   108  H HH22 . ARG   A 1 40  ? 12.141 -3.721  16.091 1.00 27.18 ? 20  ARG   A HH22 1 
ATOM   109  N N    . GLN   A 1 41  ? 12.501 3.259   11.932 1.00 26.83 ? 21  GLN   A N    1 
ATOM   110  C CA   . GLN   A 1 41  ? 12.598 3.942   10.649 1.00 20.97 ? 21  GLN   A CA   1 
ATOM   111  C C    . GLN   A 1 41  ? 13.402 5.229   10.775 1.00 20.90 ? 21  GLN   A C    1 
ATOM   112  O O    . GLN   A 1 41  ? 14.254 5.530   9.932  1.00 20.79 ? 21  GLN   A O    1 
ATOM   113  C CB   . GLN   A 1 41  ? 11.204 4.246   10.103 1.00 36.89 ? 21  GLN   A CB   1 
ATOM   114  C CG   . GLN   A 1 41  ? 11.225 5.053   8.825  1.00 49.01 ? 21  GLN   A CG   1 
ATOM   115  H H    . GLN   A 1 41  ? 11.703 3.185   12.246 1.00 32.21 ? 21  GLN   A H    1 
ATOM   116  H HA   . GLN   A 1 41  ? 13.047 3.356   10.021 1.00 25.18 ? 21  GLN   A HA   1 
ATOM   117  H HB2  . GLN   A 1 41  ? 10.750 3.409   9.919  1.00 44.28 ? 21  GLN   A HB2  1 
ATOM   118  H HB3  . GLN   A 1 41  ? 10.710 4.752   10.767 1.00 44.28 ? 21  GLN   A HB3  1 
ATOM   119  H HG2  . GLN   A 1 41  ? 11.497 5.961   9.032  1.00 58.82 ? 21  GLN   A HG2  1 
ATOM   120  H HG3  . GLN   A 1 41  ? 11.859 4.648   8.212  1.00 58.82 ? 21  GLN   A HG3  1 
ATOM   121  N N    . HIS   A 1 42  ? 13.145 6.000   11.826 1.00 22.74 ? 22  HIS   A N    1 
ATOM   122  C CA   . HIS   A 1 42  ? 13.892 7.233   12.023 1.00 20.41 ? 22  HIS   A CA   1 
ATOM   123  C C    . HIS   A 1 42  ? 15.345 6.941   12.358 1.00 18.18 ? 22  HIS   A C    1 
ATOM   124  O O    . HIS   A 1 42  ? 16.263 7.567   11.809 1.00 17.94 ? 22  HIS   A O    1 
ATOM   125  C CB   . HIS   A 1 42  ? 13.268 8.048   13.143 1.00 21.20 ? 22  HIS   A CB   1 
ATOM   126  C CG   . HIS   A 1 42  ? 14.180 9.104   13.665 1.00 22.54 ? 22  HIS   A CG   1 
ATOM   127  N ND1  . HIS   A 1 42  ? 14.326 10.327  13.045 1.00 22.75 ? 22  HIS   A ND1  1 
ATOM   128  C CD2  . HIS   A 1 42  ? 15.038 9.103   14.711 1.00 19.05 ? 22  HIS   A CD2  1 
ATOM   129  C CE1  . HIS   A 1 42  ? 15.216 11.044  13.706 1.00 23.75 ? 22  HIS   A CE1  1 
ATOM   130  N NE2  . HIS   A 1 42  ? 15.657 10.328  14.725 1.00 20.42 ? 22  HIS   A NE2  1 
ATOM   131  H H    . HIS   A 1 42  ? 12.554 5.834   12.429 1.00 27.30 ? 22  HIS   A H    1 
ATOM   132  H HA   . HIS   A 1 42  ? 13.854 7.749   11.203 1.00 24.50 ? 22  HIS   A HA   1 
ATOM   133  H HB2  . HIS   A 1 42  ? 12.467 8.482   12.809 1.00 25.45 ? 22  HIS   A HB2  1 
ATOM   134  H HB3  . HIS   A 1 42  ? 13.043 7.456   13.877 1.00 25.45 ? 22  HIS   A HB3  1 
ATOM   135  H HD2  . HIS   A 1 42  ? 15.181 8.404   15.308 1.00 22.87 ? 22  HIS   A HD2  1 
ATOM   136  H HE1  . HIS   A 1 42  ? 15.487 11.907  13.491 1.00 28.51 ? 22  HIS   A HE1  1 
ATOM   137  H HE2  . HIS   A 1 42  ? 16.237 10.587  15.304 1.00 24.51 ? 22  HIS   A HE2  1 
ATOM   138  N N    . ASN   A 1 43  ? 15.565 6.004   13.281 1.00 19.73 ? 23  ASN   A N    1 
ATOM   139  C CA   . ASN   A 1 43  ? 16.925 5.701   13.718 1.00 18.78 ? 23  ASN   A CA   1 
ATOM   140  C C    . ASN   A 1 43  ? 17.776 5.235   12.550 1.00 18.25 ? 23  ASN   A C    1 
ATOM   141  O O    . ASN   A 1 43  ? 18.949 5.596   12.438 1.00 15.81 ? 23  ASN   A O    1 
ATOM   142  C CB   . ASN   A 1 43  ? 16.899 4.639   14.816 1.00 17.94 ? 23  ASN   A CB   1 
ATOM   143  C CG   . ASN   A 1 43  ? 16.228 5.129   16.090 1.00 19.36 ? 23  ASN   A CG   1 
ATOM   144  O OD1  . ASN   A 1 43  ? 16.076 6.338   16.304 1.00 20.13 ? 23  ASN   A OD1  1 
ATOM   145  N ND2  . ASN   A 1 43  ? 15.836 4.198   16.950 1.00 20.24 ? 23  ASN   A ND2  1 
ATOM   146  H H    . ASN   A 1 43  ? 14.953 5.536   13.664 1.00 23.68 ? 23  ASN   A H    1 
ATOM   147  H HA   . ASN   A 1 43  ? 17.324 6.504   14.087 1.00 22.54 ? 23  ASN   A HA   1 
ATOM   148  H HB2  . ASN   A 1 43  ? 16.408 3.865   14.497 1.00 21.54 ? 23  ASN   A HB2  1 
ATOM   149  H HB3  . ASN   A 1 43  ? 17.810 4.387   15.035 1.00 21.54 ? 23  ASN   A HB3  1 
ATOM   150  H HD21 . ASN   A 1 43  ? 15.452 4.425   17.684 1.00 24.30 ? 23  ASN   A HD21 1 
ATOM   151  H HD22 . ASN   A 1 43  ? 15.967 3.366   16.772 1.00 24.30 ? 23  ASN   A HD22 1 
ATOM   152  N N    . ARG   A 1 44  ? 17.196 4.452   11.649 1.00 17.45 ? 24  ARG   A N    1 
ATOM   153  C CA   . ARG   A 1 44  ? 17.952 4.005   10.490 1.00 17.27 ? 24  ARG   A CA   1 
ATOM   154  C C    . ARG   A 1 44  ? 18.463 5.185   9.677  1.00 16.31 ? 24  ARG   A C    1 
ATOM   155  O O    . ARG   A 1 44  ? 19.587 5.164   9.168  1.00 17.05 ? 24  ARG   A O    1 
ATOM   156  C CB   . ARG   A 1 44  ? 17.088 3.097   9.610  1.00 19.31 ? 24  ARG   A CB   1 
ATOM   157  C CG   . ARG   A 1 44  ? 17.856 2.652   8.410  1.00 25.33 ? 24  ARG   A CG   1 
ATOM   158  C CD   . ARG   A 1 44  ? 17.059 1.818   7.443  1.00 32.07 ? 24  ARG   A CD   1 
ATOM   159  N NE   . ARG   A 1 44  ? 17.930 1.394   6.354  1.00 51.39 ? 24  ARG   A NE   1 
ATOM   160  C CZ   . ARG   A 1 44  ? 18.474 0.191   6.253  1.00 32.13 ? 24  ARG   A CZ   1 
ATOM   161  N NH1  . ARG   A 1 44  ? 18.148 -0.786  7.083  1.00 44.48 ? 24  ARG   A NH1  1 
ATOM   162  N NH2  . ARG   A 1 44  ? 19.369 -0.038  5.295  1.00 40.04 ? 24  ARG   A NH2  1 
ATOM   163  H H    . ARG   A 1 44  ? 16.384 4.172   11.685 1.00 20.95 ? 24  ARG   A H    1 
ATOM   164  H HA   . ARG   A 1 44  ? 18.714 3.491   10.800 1.00 20.74 ? 24  ARG   A HA   1 
ATOM   165  H HB2  . ARG   A 1 44  ? 16.822 2.313   10.116 1.00 23.18 ? 24  ARG   A HB2  1 
ATOM   166  H HB3  . ARG   A 1 44  ? 16.303 3.583   9.314  1.00 23.18 ? 24  ARG   A HB3  1 
ATOM   167  H HG2  . ARG   A 1 44  ? 18.169 3.436   7.932  1.00 30.41 ? 24  ARG   A HG2  1 
ATOM   168  H HG3  . ARG   A 1 44  ? 18.612 2.119   8.703  1.00 30.41 ? 24  ARG   A HG3  1 
ATOM   169  H HD2  . ARG   A 1 44  ? 16.710 1.033   7.893  1.00 38.50 ? 24  ARG   A HD2  1 
ATOM   170  H HD3  . ARG   A 1 44  ? 16.329 2.342   7.078  1.00 38.50 ? 24  ARG   A HD3  1 
ATOM   171  H HE   . ARG   A 1 44  ? 18.103 1.965   5.735  1.00 61.69 ? 24  ARG   A HE   1 
ATOM   172  H HH11 . ARG   A 1 44  ? 18.513 -1.560  7.001  1.00 53.39 ? 24  ARG   A HH11 1 
ATOM   173  H HH12 . ARG   A 1 44  ? 17.571 -0.646  7.705  1.00 53.39 ? 24  ARG   A HH12 1 
ATOM   174  H HH21 . ARG   A 1 44  ? 19.729 -0.816  5.219  1.00 48.06 ? 24  ARG   A HH21 1 
ATOM   175  H HH22 . ARG   A 1 44  ? 19.587 0.591   4.751  1.00 48.06 ? 24  ARG   A HH22 1 
ATOM   176  N N    . LYS   A 1 45  ? 17.641 6.230   9.528  1.00 19.94 ? 25  LYS   A N    1 
ATOM   177  C CA   . LYS   A 1 45  ? 18.084 7.402   8.786  1.00 15.72 ? 25  LYS   A CA   1 
ATOM   178  C C    . LYS   A 1 45  ? 19.283 8.059   9.454  1.00 13.63 ? 25  LYS   A C    1 
ATOM   179  O O    . LYS   A 1 45  ? 20.189 8.552   8.772  1.00 16.73 ? 25  LYS   A O    1 
ATOM   180  C CB   . LYS   A 1 45  ? 16.940 8.407   8.653  1.00 22.37 ? 25  LYS   A CB   1 
ATOM   181  C CG   . LYS   A 1 45  ? 15.739 7.886   7.886  1.00 42.06 ? 25  LYS   A CG   1 
ATOM   182  C CD   . LYS   A 1 45  ? 14.695 8.977   7.703  1.00 59.06 ? 25  LYS   A CD   1 
ATOM   183  C CE   . LYS   A 1 45  ? 13.423 8.425   7.078  1.00 70.52 ? 25  LYS   A CE   1 
ATOM   184  N NZ   . LYS   A 1 45  ? 12.383 9.476   6.889  1.00 74.73 ? 25  LYS   A NZ   1 
ATOM   185  H H    . LYS   A 1 45  ? 16.841 6.279   9.842  1.00 23.94 ? 25  LYS   A H    1 
ATOM   186  H HA   . LYS   A 1 45  ? 18.346 7.120   7.896  1.00 18.88 ? 25  LYS   A HA   1 
ATOM   187  H HB2  . LYS   A 1 45  ? 16.639 8.653   9.541  1.00 26.85 ? 25  LYS   A HB2  1 
ATOM   188  H HB3  . LYS   A 1 45  ? 17.270 9.191   8.186  1.00 26.85 ? 25  LYS   A HB3  1 
ATOM   189  H HG2  . LYS   A 1 45  ? 16.021 7.582   7.010  1.00 50.49 ? 25  LYS   A HG2  1 
ATOM   190  H HG3  . LYS   A 1 45  ? 15.335 7.154   8.377  1.00 50.49 ? 25  LYS   A HG3  1 
ATOM   191  H HD2  . LYS   A 1 45  ? 14.471 9.357   8.567  1.00 70.89 ? 25  LYS   A HD2  1 
ATOM   192  H HD3  . LYS   A 1 45  ? 15.048 9.667   7.119  1.00 70.89 ? 25  LYS   A HD3  1 
ATOM   193  H HE2  . LYS   A 1 45  ? 13.633 8.049   6.209  1.00 84.63 ? 25  LYS   A HE2  1 
ATOM   194  H HE3  . LYS   A 1 45  ? 13.056 7.739   7.657  1.00 84.63 ? 25  LYS   A HE3  1 
ATOM   195  H HZ1  . LYS   A 1 45  ? 11.630 9.109   6.588  1.00 89.69 ? 25  LYS   A HZ1  1 
ATOM   196  H HZ2  . LYS   A 1 45  ? 12.217 9.883   7.664  1.00 89.69 ? 25  LYS   A HZ2  1 
ATOM   197  H HZ3  . LYS   A 1 45  ? 12.665 10.081  6.300  1.00 89.69 ? 25  LYS   A HZ3  1 
ATOM   198  N N    . ILE   A 1 46  ? 19.295 8.092   10.786 1.00 16.34 ? 26  ILE   A N    1 
ATOM   199  C CA   . ILE   A 1 46  ? 20.436 8.656   11.496 1.00 16.18 ? 26  ILE   A CA   1 
ATOM   200  C C    . ILE   A 1 46  ? 21.684 7.812   11.256 1.00 14.56 ? 26  ILE   A C    1 
ATOM   201  O O    . ILE   A 1 46  ? 22.779 8.340   11.030 1.00 15.78 ? 26  ILE   A O    1 
ATOM   202  C CB   . ILE   A 1 46  ? 20.122 8.774   12.996 1.00 14.98 ? 26  ILE   A CB   1 
ATOM   203  C CG1  . ILE   A 1 46  ? 18.955 9.731   13.231 1.00 25.39 ? 26  ILE   A CG1  1 
ATOM   204  C CG2  . ILE   A 1 46  ? 21.356 9.220   13.759 1.00 16.24 ? 26  ILE   A CG2  1 
ATOM   205  C CD1  . ILE   A 1 46  ? 19.170 11.118  12.675 1.00 24.96 ? 26  ILE   A CD1  1 
ATOM   206  H H    . ILE   A 1 46  ? 18.666 7.798   11.293 1.00 19.62 ? 26  ILE   A H    1 
ATOM   207  H HA   . ILE   A 1 46  ? 20.603 9.546   11.149 1.00 19.42 ? 26  ILE   A HA   1 
ATOM   208  H HB   . ILE   A 1 46  ? 19.860 7.900   13.325 1.00 17.99 ? 26  ILE   A HB   1 
ATOM   209  H HG12 . ILE   A 1 46  ? 18.163 9.364   12.807 1.00 30.48 ? 26  ILE   A HG12 1 
ATOM   210  H HG13 . ILE   A 1 46  ? 18.811 9.816   14.186 1.00 30.48 ? 26  ILE   A HG13 1 
ATOM   211  H HG21 . ILE   A 1 46  ? 21.103 9.433   14.671 1.00 19.51 ? 26  ILE   A HG21 1 
ATOM   212  H HG22 . ILE   A 1 46  ? 22.006 8.501   13.755 1.00 19.51 ? 26  ILE   A HG22 1 
ATOM   213  H HG23 . ILE   A 1 46  ? 21.728 10.005  13.326 1.00 19.51 ? 26  ILE   A HG23 1 
ATOM   214  H HD11 . ILE   A 1 46  ? 18.464 11.701  12.997 1.00 29.97 ? 26  ILE   A HD11 1 
ATOM   215  H HD12 . ILE   A 1 46  ? 20.032 11.448  12.974 1.00 29.97 ? 26  ILE   A HD12 1 
ATOM   216  H HD13 . ILE   A 1 46  ? 19.149 11.077  11.706 1.00 29.97 ? 26  ILE   A HD13 1 
ATOM   217  N N    . VAL   A 1 47  ? 21.545 6.491   11.328 1.00 14.83 ? 27  VAL   A N    1 
ATOM   218  C CA   . VAL   A 1 47  ? 22.693 5.622   11.075 1.00 15.34 ? 27  VAL   A CA   1 
ATOM   219  C C    . VAL   A 1 47  ? 23.231 5.862   9.674  1.00 16.85 ? 27  VAL   A C    1 
ATOM   220  O O    . VAL   A 1 47  ? 24.438 6.024   9.474  1.00 15.48 ? 27  VAL   A O    1 
ATOM   221  C CB   . VAL   A 1 47  ? 22.315 4.148   11.291 1.00 13.72 ? 27  VAL   A CB   1 
ATOM   222  C CG1  . VAL   A 1 47  ? 23.474 3.251   10.854 1.00 16.19 ? 27  VAL   A CG1  1 
ATOM   223  C CG2  . VAL   A 1 47  ? 21.962 3.896   12.740 1.00 17.25 ? 27  VAL   A CG2  1 
ATOM   224  H H    . VAL   A 1 47  ? 20.814 6.080   11.517 1.00 17.80 ? 27  VAL   A H    1 
ATOM   225  H HA   . VAL   A 1 47  ? 23.393 5.842   11.710 1.00 18.43 ? 27  VAL   A HA   1 
ATOM   226  H HB   . VAL   A 1 47  ? 21.535 3.934   10.755 1.00 16.48 ? 27  VAL   A HB   1 
ATOM   227  H HG11 . VAL   A 1 47  ? 23.335 2.359   11.209 1.00 19.44 ? 27  VAL   A HG11 1 
ATOM   228  H HG12 . VAL   A 1 47  ? 23.502 3.220   9.885  1.00 19.44 ? 27  VAL   A HG12 1 
ATOM   229  H HG13 . VAL   A 1 47  ? 24.304 3.617   11.198 1.00 19.44 ? 27  VAL   A HG13 1 
ATOM   230  H HG21 . VAL   A 1 47  ? 21.968 2.940   12.904 1.00 20.71 ? 27  VAL   A HG21 1 
ATOM   231  H HG22 . VAL   A 1 47  ? 22.618 4.333   13.305 1.00 20.71 ? 27  VAL   A HG22 1 
ATOM   232  H HG23 . VAL   A 1 47  ? 21.079 4.257   12.917 1.00 20.71 ? 27  VAL   A HG23 1 
ATOM   233  N N    . GLU   A 1 48  ? 22.338 5.903   8.681  1.00 18.47 ? 28  GLU   A N    1 
ATOM   234  C CA   . GLU   A 1 48  ? 22.765 6.201   7.320  1.00 19.75 ? 28  GLU   A CA   1 
ATOM   235  C C    . GLU   A 1 48  ? 23.495 7.532   7.268  1.00 16.16 ? 28  GLU   A C    1 
ATOM   236  O O    . GLU   A 1 48  ? 24.578 7.643   6.686  1.00 18.79 ? 28  GLU   A O    1 
ATOM   237  C CB   . GLU   A 1 48  ? 21.557 6.220   6.379  1.00 21.07 ? 28  GLU   A CB   1 
ATOM   238  C CG   . GLU   A 1 48  ? 20.989 4.841   6.127  1.00 26.30 ? 28  GLU   A CG   1 
ATOM   239  C CD   . GLU   A 1 48  ? 19.611 4.854   5.506  1.00 59.06 ? 28  GLU   A CD   1 
ATOM   240  O OE1  . GLU   A 1 48  ? 18.998 5.938   5.389  1.00 47.56 ? 28  GLU   A OE1  1 
ATOM   241  O OE2  . GLU   A 1 48  ? 19.128 3.765   5.135  1.00 48.86 ? 28  GLU   A OE2  1 
ATOM   242  H H    . GLU   A 1 48  ? 21.495 5.763   8.771  1.00 22.18 ? 28  GLU   A H    1 
ATOM   243  H HA   . GLU   A 1 48  ? 23.368 5.502   7.020  1.00 23.71 ? 28  GLU   A HA   1 
ATOM   244  H HB2  . GLU   A 1 48  ? 20.859 6.766   6.773  1.00 25.30 ? 28  GLU   A HB2  1 
ATOM   245  H HB3  . GLU   A 1 48  ? 21.828 6.594   5.525  1.00 25.30 ? 28  GLU   A HB3  1 
ATOM   246  H HG2  . GLU   A 1 48  ? 21.581 4.365   5.524  1.00 31.58 ? 28  GLU   A HG2  1 
ATOM   247  H HG3  . GLU   A 1 48  ? 20.928 4.370   6.973  1.00 31.58 ? 28  GLU   A HG3  1 
ATOM   248  N N    . GLN   A 1 49  ? 22.923 8.559   7.889  1.00 17.25 ? 29  GLN   A N    1 
ATOM   249  C CA   . GLN   A 1 49  ? 23.571 9.859   7.835  1.00 18.01 ? 29  GLN   A CA   1 
ATOM   250  C C    . GLN   A 1 49  ? 24.946 9.808   8.488  1.00 17.50 ? 29  GLN   A C    1 
ATOM   251  O O    . GLN   A 1 49  ? 25.915 10.353  7.958  1.00 18.02 ? 29  GLN   A O    1 
ATOM   252  C CB   . GLN   A 1 49  ? 22.707 10.917  8.508  1.00 20.17 ? 29  GLN   A CB   1 
ATOM   253  C CG   . GLN   A 1 49  ? 23.373 12.257  8.417  1.00 20.94 ? 29  GLN   A CG   1 
ATOM   254  C CD   . GLN   A 1 49  ? 22.633 13.334  9.143  1.00 22.64 ? 29  GLN   A CD   1 
ATOM   255  O OE1  . GLN   A 1 49  ? 21.454 13.187  9.470  1.00 24.75 ? 29  GLN   A OE1  1 
ATOM   256  N NE2  . GLN   A 1 49  ? 23.320 14.436  9.402  1.00 24.24 ? 29  GLN   A NE2  1 
ATOM   257  H H    . GLN   A 1 49  ? 22.186 8.529   8.331  1.00 20.72 ? 29  GLN   A H    1 
ATOM   258  H HA   . GLN   A 1 49  ? 23.679 10.111  6.905  1.00 21.63 ? 29  GLN   A HA   1 
ATOM   259  H HB2  . GLN   A 1 49  ? 21.846 10.965  8.064  1.00 24.21 ? 29  GLN   A HB2  1 
ATOM   260  H HB3  . GLN   A 1 49  ? 22.586 10.692  9.444  1.00 24.21 ? 29  GLN   A HB3  1 
ATOM   261  H HG2  . GLN   A 1 49  ? 24.260 12.194  8.803  1.00 25.14 ? 29  GLN   A HG2  1 
ATOM   262  H HG3  . GLN   A 1 49  ? 23.434 12.515  7.484  1.00 25.14 ? 29  GLN   A HG3  1 
ATOM   263  H HE21 . GLN   A 1 49  ? 24.141 14.499  9.155  1.00 29.10 ? 29  GLN   A HE21 1 
ATOM   264  H HE22 . GLN   A 1 49  ? 22.945 15.089  9.818  1.00 29.10 ? 29  GLN   A HE22 1 
ATOM   265  N N    . TYR   A 1 50  ? 25.046 9.154   9.640  1.00 15.82 ? 30  TYR   A N    1 
ATOM   266  C CA   . TYR   A 1 50  ? 26.335 9.032   10.305 1.00 12.60 ? 30  TYR   A CA   1 
ATOM   267  C C    . TYR   A 1 50  ? 27.355 8.370   9.393  1.00 13.80 ? 30  TYR   A C    1 
ATOM   268  O O    . TYR   A 1 50  ? 28.475 8.862   9.228  1.00 16.11 ? 30  TYR   A O    1 
ATOM   269  C CB   . TYR   A 1 50  ? 26.167 8.233   11.601 1.00 13.99 ? 30  TYR   A CB   1 
ATOM   270  C CG   . TYR   A 1 50  ? 27.405 8.111   12.451 1.00 11.98 ? 30  TYR   A CG   1 
ATOM   271  C CD1  . TYR   A 1 50  ? 28.453 7.278   12.080 1.00 14.25 ? 30  TYR   A CD1  1 
ATOM   272  C CD2  . TYR   A 1 50  ? 27.506 8.795   13.646 1.00 15.77 ? 30  TYR   A CD2  1 
ATOM   273  C CE1  . TYR   A 1 50  ? 29.570 7.152   12.868 1.00 14.63 ? 30  TYR   A CE1  1 
ATOM   274  C CE2  . TYR   A 1 50  ? 28.613 8.677   14.438 1.00 13.93 ? 30  TYR   A CE2  1 
ATOM   275  C CZ   . TYR   A 1 50  ? 29.645 7.852   14.046 1.00 15.19 ? 30  TYR   A CZ   1 
ATOM   276  O OH   . TYR   A 1 50  ? 30.761 7.729   14.828 1.00 16.01 ? 30  TYR   A OH   1 
ATOM   277  H H    . TYR   A 1 50  ? 24.392 8.778   10.052 1.00 19.00 ? 30  TYR   A H    1 
ATOM   278  H HA   . TYR   A 1 50  ? 26.664 9.915   10.532 1.00 15.13 ? 30  TYR   A HA   1 
ATOM   279  H HB2  . TYR   A 1 50  ? 25.487 8.666   12.141 1.00 16.80 ? 30  TYR   A HB2  1 
ATOM   280  H HB3  . TYR   A 1 50  ? 25.885 7.334   11.371 1.00 16.80 ? 30  TYR   A HB3  1 
ATOM   281  H HD1  . TYR   A 1 50  ? 28.397 6.799   11.285 1.00 17.12 ? 30  TYR   A HD1  1 
ATOM   282  H HD2  . TYR   A 1 50  ? 26.807 9.346   13.916 1.00 18.93 ? 30  TYR   A HD2  1 
ATOM   283  H HE1  . TYR   A 1 50  ? 30.268 6.596   12.606 1.00 17.57 ? 30  TYR   A HE1  1 
ATOM   284  H HE2  . TYR   A 1 50  ? 28.669 9.151   15.236 1.00 16.73 ? 30  TYR   A HE2  1 
ATOM   285  H HH   . TYR   A 1 50  ? 31.362 7.317   14.409 1.00 19.23 ? 30  TYR   A HH   1 
ATOM   286  N N    . MET   A 1 51  ? 26.986 7.240   8.797  1.00 16.01 ? 31  MET   A N    1 
ATOM   287  C CA   . MET   A 1 51  ? 27.950 6.490   8.007  1.00 13.99 ? 31  MET   A CA   1 
ATOM   288  C C    . MET   A 1 51  ? 28.366 7.230   6.753  1.00 13.86 ? 31  MET   A C    1 
ATOM   289  O O    . MET   A 1 51  ? 29.442 6.963   6.207  1.00 16.11 ? 31  MET   A O    1 
ATOM   290  C CB   . MET   A 1 51  ? 27.375 5.113   7.634  1.00 14.84 ? 31  MET   A CB   1 
ATOM   291  C CG   . MET   A 1 51  ? 27.028 4.245   8.825  1.00 15.95 ? 31  MET   A CG   1 
ATOM   292  S SD   . MET   A 1 51  ? 28.399 4.006   9.973  1.00 15.01 ? 31  MET   A SD   1 
ATOM   293  C CE   . MET   A 1 51  ? 29.686 3.400   8.887  1.00 16.34 ? 31  MET   A CE   1 
ATOM   294  H H    . MET   A 1 51  ? 26.199 6.894   8.834  1.00 19.22 ? 31  MET   A H    1 
ATOM   295  H HA   . MET   A 1 51  ? 28.738 6.341   8.553  1.00 16.80 ? 31  MET   A HA   1 
ATOM   296  H HB2  . MET   A 1 51  ? 26.565 5.244   7.118  1.00 17.82 ? 31  MET   A HB2  1 
ATOM   297  H HB3  . MET   A 1 51  ? 28.033 4.635   7.104  1.00 17.82 ? 31  MET   A HB3  1 
ATOM   298  H HG2  . MET   A 1 51  ? 26.302 4.663   9.314  1.00 19.15 ? 31  MET   A HG2  1 
ATOM   299  H HG3  . MET   A 1 51  ? 26.753 3.371   8.506  1.00 19.15 ? 31  MET   A HG3  1 
ATOM   300  H HE1  . MET   A 1 51  ? 30.485 3.228   9.409  1.00 19.62 ? 31  MET   A HE1  1 
ATOM   301  H HE2  . MET   A 1 51  ? 29.383 2.580   8.466  1.00 19.62 ? 31  MET   A HE2  1 
ATOM   302  H HE3  . MET   A 1 51  ? 29.870 4.071   8.211  1.00 19.62 ? 31  MET   A HE3  1 
ATOM   303  N N    . HIS   A 1 52  ? 27.550 8.162   6.289  1.00 15.35 ? 32  HIS   A N    1 
ATOM   304  C CA   . HIS   A 1 52  ? 27.888 8.921   5.102  1.00 18.98 ? 32  HIS   A CA   1 
ATOM   305  C C    . HIS   A 1 52  ? 28.433 10.302  5.421  1.00 18.36 ? 32  HIS   A C    1 
ATOM   306  O O    . HIS   A 1 52  ? 28.690 11.087  4.502  1.00 20.63 ? 32  HIS   A O    1 
ATOM   307  C CB   . HIS   A 1 52  ? 26.665 8.975   4.198  1.00 19.42 ? 32  HIS   A CB   1 
ATOM   308  C CG   . HIS   A 1 52  ? 26.376 7.655   3.553  1.00 21.84 ? 32  HIS   A CG   1 
ATOM   309  N ND1  . HIS   A 1 52  ? 27.088 7.196   2.467  1.00 39.02 ? 32  HIS   A ND1  1 
ATOM   310  C CD2  . HIS   A 1 52  ? 25.499 6.674   3.869  1.00 34.60 ? 32  HIS   A CD2  1 
ATOM   311  C CE1  . HIS   A 1 52  ? 26.646 6.001   2.123  1.00 31.55 ? 32  HIS   A CE1  1 
ATOM   312  N NE2  . HIS   A 1 52  ? 25.679 5.662   2.955  1.00 34.61 ? 32  HIS   A NE2  1 
ATOM   313  H H    . HIS   A 1 52  ? 26.795 8.371   6.646  1.00 18.43 ? 32  HIS   A H    1 
ATOM   314  H HA   . HIS   A 1 52  ? 28.594 8.476   4.609  1.00 22.78 ? 32  HIS   A HA   1 
ATOM   315  H HB2  . HIS   A 1 52  ? 25.891 9.230   4.725  1.00 23.31 ? 32  HIS   A HB2  1 
ATOM   316  H HB3  . HIS   A 1 52  ? 26.817 9.628   3.496  1.00 23.31 ? 32  HIS   A HB3  1 
ATOM   317  H HD2  . HIS   A 1 52  ? 24.890 6.682   4.571  1.00 41.54 ? 32  HIS   A HD2  1 
ATOM   318  H HE1  . HIS   A 1 52  ? 26.961 5.487   1.416  1.00 37.88 ? 32  HIS   A HE1  1 
ATOM   319  H HE2  . HIS   A 1 52  ? 25.233 4.927   2.930  1.00 41.54 ? 32  HIS   A HE2  1 
ATOM   320  N N    . THR   A 1 53  ? 28.700 10.589  6.691  1.00 15.81 ? 33  THR   A N    1 
ATOM   321  C CA   . THR   A 1 53  ? 29.265 11.877  7.072  1.00 15.25 ? 33  THR   A CA   1 
ATOM   322  C C    . THR   A 1 53  ? 30.755 11.900  6.758  1.00 19.14 ? 33  THR   A C    1 
ATOM   323  O O    . THR   A 1 53  ? 31.527 11.076  7.268  1.00 19.99 ? 33  THR   A O    1 
ATOM   324  C CB   . THR   A 1 53  ? 29.012 12.169  8.553  1.00 16.41 ? 33  THR   A CB   1 
ATOM   325  O OG1  . THR   A 1 53  ? 27.602 12.235  8.787  1.00 17.71 ? 33  THR   A OG1  1 
ATOM   326  C CG2  . THR   A 1 53  ? 29.635 13.497  8.948  1.00 18.56 ? 33  THR   A CG2  1 
ATOM   327  H H    . THR   A 1 53  ? 28.564 10.054  7.350  1.00 18.99 ? 33  THR   A H    1 
ATOM   328  H HA   . THR   A 1 53  ? 28.834 12.575  6.555  1.00 18.31 ? 33  THR   A HA   1 
ATOM   329  H HB   . THR   A 1 53  ? 29.407 11.467  9.093  1.00 19.71 ? 33  THR   A HB   1 
ATOM   330  H HG1  . THR   A 1 53  ? 27.246 11.497  8.603  1.00 21.27 ? 33  THR   A HG1  1 
ATOM   331  H HG21 . THR   A 1 53  ? 29.409 13.708  9.868  1.00 22.29 ? 33  THR   A HG21 1 
ATOM   332  H HG22 . THR   A 1 53  ? 30.600 13.449  8.864  1.00 22.29 ? 33  THR   A HG22 1 
ATOM   333  H HG23 . THR   A 1 53  ? 29.303 14.204  8.373  1.00 22.29 ? 33  THR   A HG23 1 
ATOM   334  N N    . ARG   A 1 54  ? 31.157 12.861  5.926  1.00 16.19 ? 34  ARG   A N    1 
ATOM   335  C CA   A ARG   A 1 54  ? 32.529 12.996  5.472  0.47 14.98 ? 34  ARG   A CA   1 
ATOM   336  C CA   B ARG   A 1 54  ? 32.548 12.986  5.527  0.53 14.92 ? 34  ARG   A CA   1 
ATOM   337  C C    . ARG   A 1 54  ? 32.949 14.452  5.525  1.00 15.78 ? 34  ARG   A C    1 
ATOM   338  O O    . ARG   A 1 54  ? 32.108 15.348  5.584  1.00 19.49 ? 34  ARG   A O    1 
ATOM   339  C CB   A ARG   A 1 54  ? 32.699 12.527  4.027  0.47 19.46 ? 34  ARG   A CB   1 
ATOM   340  C CB   B ARG   A 1 54  ? 32.792 12.363  4.133  0.53 19.59 ? 34  ARG   A CB   1 
ATOM   341  C CG   A ARG   A 1 54  ? 32.807 11.063  3.817  0.47 12.94 ? 34  ARG   A CG   1 
ATOM   342  C CG   B ARG   A 1 54  ? 31.744 11.329  3.720  0.53 30.70 ? 34  ARG   A CG   1 
ATOM   343  C CD   A ARG   A 1 54  ? 32.868 10.814  2.328  0.47 20.33 ? 34  ARG   A CD   1 
ATOM   344  C CD   B ARG   A 1 54  ? 32.195 10.428  2.564  0.53 26.62 ? 34  ARG   A CD   1 
ATOM   345  N NE   A ARG   A 1 54  ? 32.477 9.451   2.010  0.47 18.87 ? 34  ARG   A NE   1 
ATOM   346  N NE   B ARG   A 1 54  ? 32.744 11.152  1.424  0.53 21.85 ? 34  ARG   A NE   1 
ATOM   347  C CZ   A ARG   A 1 54  ? 32.165 9.030   0.794  0.47 31.13 ? 34  ARG   A CZ   1 
ATOM   348  C CZ   B ARG   A 1 54  ? 32.945 10.613  0.225  0.53 19.76 ? 34  ARG   A CZ   1 
ATOM   349  N NH1  A ARG   A 1 54  ? 32.191 9.847   -0.248 0.47 23.36 ? 34  ARG   A NH1  1 
ATOM   350  N NH1  B ARG   A 1 54  ? 32.635 9.352   -0.027 0.53 24.84 ? 34  ARG   A NH1  1 
ATOM   351  N NH2  A ARG   A 1 54  ? 31.809 7.762   0.621  0.47 26.29 ? 34  ARG   A NH2  1 
ATOM   352  N NH2  B ARG   A 1 54  ? 33.456 11.362  -0.746 0.53 18.84 ? 34  ARG   A NH2  1 
ATOM   353  H H    A ARG   A 1 54  ? 30.634 13.462  5.604  0.47 19.44 ? 34  ARG   A H    1 
ATOM   354  H H    B ARG   A 1 54  ? 30.637 13.452  5.581  0.53 19.44 ? 34  ARG   A H    1 
ATOM   355  H HA   A ARG   A 1 54  ? 33.090 12.470  6.063  0.47 17.98 ? 34  ARG   A HA   1 
ATOM   356  H HA   B ARG   A 1 54  ? 33.108 12.526  6.172  0.53 17.92 ? 34  ARG   A HA   1 
ATOM   357  H HB2  A ARG   A 1 54  ? 31.932 12.833  3.519  0.47 23.36 ? 34  ARG   A HB2  1 
ATOM   358  H HB2  B ARG   A 1 54  ? 32.784 13.072  3.471  0.53 23.52 ? 34  ARG   A HB2  1 
ATOM   359  H HB3  A ARG   A 1 54  ? 33.510 12.926  3.674  0.47 23.36 ? 34  ARG   A HB3  1 
ATOM   360  H HB3  B ARG   A 1 54  ? 33.656 11.922  4.137  0.53 23.52 ? 34  ARG   A HB3  1 
ATOM   361  H HG2  A ARG   A 1 54  ? 33.615 10.723  4.233  0.47 15.54 ? 34  ARG   A HG2  1 
ATOM   362  H HG2  B ARG   A 1 54  ? 31.549 10.759  4.480  0.53 36.85 ? 34  ARG   A HG2  1 
ATOM   363  H HG3  A ARG   A 1 54  ? 32.030 10.613  4.186  0.47 15.54 ? 34  ARG   A HG3  1 
ATOM   364  H HG3  B ARG   A 1 54  ? 30.940 11.792  3.437  0.53 36.85 ? 34  ARG   A HG3  1 
ATOM   365  H HD2  A ARG   A 1 54  ? 32.263 11.421  1.874  0.47 24.41 ? 34  ARG   A HD2  1 
ATOM   366  H HD2  B ARG   A 1 54  ? 32.883 9.826   2.889  0.53 31.96 ? 34  ARG   A HD2  1 
ATOM   367  H HD3  A ARG   A 1 54  ? 33.775 10.953  2.015  0.47 24.41 ? 34  ARG   A HD3  1 
ATOM   368  H HD3  B ARG   A 1 54  ? 31.431 9.920   2.249  0.53 31.96 ? 34  ARG   A HD3  1 
ATOM   369  H HE   A ARG   A 1 54  ? 32.446 8.880   2.653  0.47 22.66 ? 34  ARG   A HE   1 
ATOM   370  H HE   B ARG   A 1 54  ? 32.952 11.979  1.534  0.53 26.23 ? 34  ARG   A HE   1 
ATOM   371  H HH11 A ARG   A 1 54  ? 32.415 10.671  -0.143 0.47 28.04 ? 34  ARG   A HH11 1 
ATOM   372  H HH11 B ARG   A 1 54  ? 32.295 8.861   0.592  0.53 29.83 ? 34  ARG   A HH11 1 
ATOM   373  H HH12 A ARG   A 1 54  ? 31.985 9.554   -1.030 0.47 28.04 ? 34  ARG   A HH12 1 
ATOM   374  H HH12 B ARG   A 1 54  ? 32.773 9.024   -0.810 0.53 29.83 ? 34  ARG   A HH12 1 
ATOM   375  H HH21 A ARG   A 1 54  ? 31.784 7.227   1.294  0.47 31.56 ? 34  ARG   A HH21 1 
ATOM   376  H HH21 B ARG   A 1 54  ? 33.654 12.185  -0.595 0.53 22.63 ? 34  ARG   A HH21 1 
ATOM   377  H HH22 A ARG   A 1 54  ? 31.603 7.476   -0.164 0.47 31.56 ? 34  ARG   A HH22 1 
ATOM   378  H HH22 B ARG   A 1 54  ? 33.590 11.023  -1.525 0.53 22.63 ? 34  ARG   A HH22 1 
ATOM   379  N N    . GLY   A 1 55  ? 34.261 14.673  5.468  1.00 19.22 ? 35  GLY   A N    1 
ATOM   380  C CA   . GLY   A 1 55  ? 34.785 16.021  5.334  1.00 20.49 ? 35  GLY   A CA   1 
ATOM   381  C C    . GLY   A 1 55  ? 34.358 16.931  6.465  1.00 22.57 ? 35  GLY   A C    1 
ATOM   382  O O    . GLY   A 1 55  ? 34.244 16.518  7.626  1.00 19.15 ? 35  GLY   A O    1 
ATOM   383  H H    . GLY   A 1 55  ? 34.864 14.061  5.504  1.00 23.08 ? 35  GLY   A H    1 
ATOM   384  H HA2  . GLY   A 1 55  ? 35.754 15.987  5.321  1.00 24.60 ? 35  GLY   A HA2  1 
ATOM   385  H HA3  . GLY   A 1 55  ? 34.471 16.405  4.501  1.00 24.60 ? 35  GLY   A HA3  1 
ATOM   386  N N    . GLU   A 1 56  ? 34.114 18.201  6.130  1.00 23.98 ? 36  GLU   A N    1 
ATOM   387  C CA   . GLU   A 1 56  ? 33.838 19.173  7.181  1.00 25.23 ? 36  GLU   A CA   1 
ATOM   388  C C    . GLU   A 1 56  ? 32.555 18.850  7.936  1.00 19.07 ? 36  GLU   A C    1 
ATOM   389  O O    . GLU   A 1 56  ? 32.410 19.272  9.091  1.00 21.47 ? 36  GLU   A O    1 
ATOM   390  C CB   . GLU   A 1 56  ? 33.751 20.588  6.596  1.00 30.64 ? 36  GLU   A CB   1 
ATOM   391  C CG   . GLU   A 1 56  ? 34.931 21.004  5.727  1.00 44.23 ? 36  GLU   A CG   1 
ATOM   392  C CD   . GLU   A 1 56  ? 36.268 20.991  6.453  1.00 55.71 ? 36  GLU   A CD   1 
ATOM   393  O OE1  . GLU   A 1 56  ? 36.354 21.481  7.599  1.00 49.55 ? 36  GLU   A OE1  1 
ATOM   394  O OE2  . GLU   A 1 56  ? 37.243 20.483  5.861  1.00 61.32 ? 36  GLU   A OE2  1 
ATOM   395  H H    . GLU   A 1 56  ? 34.103 18.512  5.328  1.00 28.78 ? 36  GLU   A H    1 
ATOM   396  H HA   . GLU   A 1 56  ? 34.575 19.160  7.811  1.00 30.29 ? 36  GLU   A HA   1 
ATOM   397  H HB2  . GLU   A 1 56  ? 32.953 20.645  6.048  1.00 36.78 ? 36  GLU   A HB2  1 
ATOM   398  H HB3  . GLU   A 1 56  ? 33.694 21.220  7.330  1.00 36.78 ? 36  GLU   A HB3  1 
ATOM   399  H HG2  . GLU   A 1 56  ? 34.996 20.392  4.977  1.00 53.09 ? 36  GLU   A HG2  1 
ATOM   400  H HG3  . GLU   A 1 56  ? 34.779 21.907  5.407  1.00 53.09 ? 36  GLU   A HG3  1 
ATOM   401  N N    . ALA   A 1 57  ? 31.632 18.103  7.316  1.00 20.58 ? 37  ALA   A N    1 
ATOM   402  C CA   . ALA   A 1 57  ? 30.425 17.687  8.021  1.00 21.78 ? 37  ALA   A CA   1 
ATOM   403  C C    . ALA   A 1 57  ? 30.744 16.845  9.247  1.00 17.82 ? 37  ALA   A C    1 
ATOM   404  O O    . ALA   A 1 57  ? 29.904 16.740  10.146 1.00 18.15 ? 37  ALA   A O    1 
ATOM   405  C CB   . ALA   A 1 57  ? 29.499 16.903  7.096  1.00 20.06 ? 37  ALA   A CB   1 
ATOM   406  H H    . ALA   A 1 57  ? 31.684 17.832  6.501  1.00 24.71 ? 37  ALA   A H    1 
ATOM   407  H HA   . ALA   A 1 57  ? 29.953 18.485  8.305  1.00 26.15 ? 37  ALA   A HA   1 
ATOM   408  H HB1  . ALA   A 1 57  ? 28.651 16.759  7.545  1.00 24.09 ? 37  ALA   A HB1  1 
ATOM   409  H HB2  . ALA   A 1 57  ? 29.359 17.413  6.282  1.00 24.09 ? 37  ALA   A HB2  1 
ATOM   410  H HB3  . ALA   A 1 57  ? 29.910 16.050  6.885  1.00 24.09 ? 37  ALA   A HB3  1 
ATOM   411  N N    . ARG   A 1 58  ? 31.928 16.235  9.299  1.00 16.21 ? 38  ARG   A N    1 
ATOM   412  C CA   . ARG   A 1 58  ? 32.315 15.474  10.483 1.00 13.75 ? 38  ARG   A CA   1 
ATOM   413  C C    . ARG   A 1 58  ? 32.368 16.355  11.723 1.00 16.69 ? 38  ARG   A C    1 
ATOM   414  O O    . ARG   A 1 58  ? 32.219 15.858  12.848 1.00 17.62 ? 38  ARG   A O    1 
ATOM   415  C CB   . ARG   A 1 58  ? 33.654 14.785  10.234 1.00 17.52 ? 38  ARG   A CB   1 
ATOM   416  C CG   . ARG   A 1 58  ? 33.512 13.613  9.280  1.00 17.56 ? 38  ARG   A CG   1 
ATOM   417  C CD   . ARG   A 1 58  ? 34.812 13.244  8.624  1.00 20.03 ? 38  ARG   A CD   1 
ATOM   418  N NE   . ARG   A 1 58  ? 35.817 12.792  9.579  1.00 18.79 ? 38  ARG   A NE   1 
ATOM   419  C CZ   . ARG   A 1 58  ? 37.081 12.566  9.252  1.00 18.13 ? 38  ARG   A CZ   1 
ATOM   420  N NH1  . ARG   A 1 58  ? 37.512 12.726  8.011  1.00 18.97 ? 38  ARG   A NH1  1 
ATOM   421  N NH2  . ARG   A 1 58  ? 37.935 12.177  10.192 1.00 18.85 ? 38  ARG   A NH2  1 
ATOM   422  H H    . ARG   A 1 58  ? 32.516 16.247  8.672  1.00 19.46 ? 38  ARG   A H    1 
ATOM   423  H HA   . ARG   A 1 58  ? 31.655 14.783  10.652 1.00 16.51 ? 38  ARG   A HA   1 
ATOM   424  H HB2  . ARG   A 1 58  ? 34.274 15.422  9.845  1.00 21.03 ? 38  ARG   A HB2  1 
ATOM   425  H HB3  . ARG   A 1 58  ? 34.004 14.452  11.075 1.00 21.03 ? 38  ARG   A HB3  1 
ATOM   426  H HG2  . ARG   A 1 58  ? 33.193 12.840  9.772  1.00 21.09 ? 38  ARG   A HG2  1 
ATOM   427  H HG3  . ARG   A 1 58  ? 32.880 13.847  8.582  1.00 21.09 ? 38  ARG   A HG3  1 
ATOM   428  H HD2  . ARG   A 1 58  ? 34.655 12.526  7.992  1.00 24.04 ? 38  ARG   A HD2  1 
ATOM   429  H HD3  . ARG   A 1 58  ? 35.166 14.021  8.163  1.00 24.04 ? 38  ARG   A HD3  1 
ATOM   430  H HE   . ARG   A 1 58  ? 35.577 12.667  10.396 1.00 22.56 ? 38  ARG   A HE   1 
ATOM   431  H HH11 . ARG   A 1 58  ? 36.968 12.983  7.397  1.00 22.78 ? 38  ARG   A HH11 1 
ATOM   432  H HH12 . ARG   A 1 58  ? 38.336 12.574  7.819  1.00 22.78 ? 38  ARG   A HH12 1 
ATOM   433  H HH21 . ARG   A 1 58  ? 37.666 12.074  11.002 1.00 22.64 ? 38  ARG   A HH21 1 
ATOM   434  H HH22 . ARG   A 1 58  ? 38.757 12.027  9.990  1.00 22.64 ? 38  ARG   A HH22 1 
ATOM   435  N N    . LEU   A 1 59  ? 32.551 17.659  11.538 1.00 18.42 ? 39  LEU   A N    1 
ATOM   436  C CA   . LEU   A 1 59  ? 32.595 18.565  12.675 1.00 20.07 ? 39  LEU   A CA   1 
ATOM   437  C C    . LEU   A 1 59  ? 31.250 18.713  13.364 1.00 18.01 ? 39  LEU   A C    1 
ATOM   438  O O    . LEU   A 1 59  ? 31.202 19.210  14.499 1.00 21.75 ? 39  LEU   A O    1 
ATOM   439  C CB   . LEU   A 1 59  ? 33.070 19.941  12.226 1.00 21.53 ? 39  LEU   A CB   1 
ATOM   440  C CG   . LEU   A 1 59  ? 34.505 19.952  11.733 1.00 25.23 ? 39  LEU   A CG   1 
ATOM   441  C CD1  . LEU   A 1 59  ? 34.814 21.331  11.184 1.00 28.44 ? 39  LEU   A CD1  1 
ATOM   442  C CD2  . LEU   A 1 59  ? 35.456 19.554  12.839 1.00 28.83 ? 39  LEU   A CD2  1 
ATOM   443  H H    . LEU   A 1 59  ? 32.652 18.038  10.772 1.00 22.12 ? 39  LEU   A H    1 
ATOM   444  H HA   . LEU   A 1 59  ? 33.226 18.207  13.318 1.00 24.10 ? 39  LEU   A HA   1 
ATOM   445  H HB2  . LEU   A 1 59  ? 32.503 20.246  11.501 1.00 25.84 ? 39  LEU   A HB2  1 
ATOM   446  H HB3  . LEU   A 1 59  ? 33.008 20.553  12.976 1.00 25.84 ? 39  LEU   A HB3  1 
ATOM   447  H HG   . LEU   A 1 59  ? 34.629 19.302  11.023 1.00 30.29 ? 39  LEU   A HG   1 
ATOM   448  H HD11 . LEU   A 1 59  ? 35.742 21.359  10.904 1.00 34.14 ? 39  LEU   A HD11 1 
ATOM   449  H HD12 . LEU   A 1 59  ? 34.234 21.506  10.426 1.00 34.14 ? 39  LEU   A HD12 1 
ATOM   450  H HD13 . LEU   A 1 59  ? 34.658 21.990  11.878 1.00 34.14 ? 39  LEU   A HD13 1 
ATOM   451  H HD21 . LEU   A 1 59  ? 36.358 19.808  12.586 1.00 34.61 ? 39  LEU   A HD21 1 
ATOM   452  H HD22 . LEU   A 1 59  ? 35.200 20.010  13.655 1.00 34.61 ? 39  LEU   A HD22 1 
ATOM   453  H HD23 . LEU   A 1 59  ? 35.407 18.593  12.967 1.00 34.61 ? 39  LEU   A HD23 1 
ATOM   454  N N    . LYS   A 1 60  ? 30.161 18.324  12.703 1.00 18.38 ? 40  LYS   A N    1 
ATOM   455  C CA   . LYS   A 1 60  ? 28.832 18.420  13.283 1.00 19.06 ? 40  LYS   A CA   1 
ATOM   456  C C    . LYS   A 1 60  ? 28.203 17.055  13.517 1.00 19.09 ? 40  LYS   A C    1 
ATOM   457  O O    . LYS   A 1 60  ? 27.012 16.980  13.833 1.00 18.92 ? 40  LYS   A O    1 
ATOM   458  C CB   . LYS   A 1 60  ? 27.919 19.257  12.387 1.00 22.73 ? 40  LYS   A CB   1 
ATOM   459  C CG   . LYS   A 1 60  ? 28.378 20.686  12.160 1.00 29.97 ? 40  LYS   A CG   1 
ATOM   460  C CD   . LYS   A 1 60  ? 28.194 21.548  13.407 1.00 45.44 ? 40  LYS   A CD   1 
ATOM   461  C CE   . LYS   A 1 60  ? 28.780 22.942  13.211 1.00 69.68 ? 40  LYS   A CE   1 
ATOM   462  N NZ   . LYS   A 1 60  ? 29.780 23.281  14.260 1.00 65.76 ? 40  LYS   A NZ   1 
ATOM   463  H H    . LYS   A 1 60  ? 30.171 17.997  11.908 1.00 22.07 ? 40  LYS   A H    1 
ATOM   464  H HA   . LYS   A 1 60  ? 28.907 18.870  14.139 1.00 22.88 ? 40  LYS   A HA   1 
ATOM   465  H HB2  . LYS   A 1 60  ? 27.863 18.828  11.519 1.00 27.29 ? 40  LYS   A HB2  1 
ATOM   466  H HB3  . LYS   A 1 60  ? 27.040 19.296  12.795 1.00 27.29 ? 40  LYS   A HB3  1 
ATOM   467  H HG2  . LYS   A 1 60  ? 29.320 20.686  11.928 1.00 35.97 ? 40  LYS   A HG2  1 
ATOM   468  H HG3  . LYS   A 1 60  ? 27.859 21.078  11.441 1.00 35.97 ? 40  LYS   A HG3  1 
ATOM   469  H HD2  . LYS   A 1 60  ? 27.247 21.640  13.598 1.00 54.54 ? 40  LYS   A HD2  1 
ATOM   470  H HD3  . LYS   A 1 60  ? 28.644 21.130  14.157 1.00 54.54 ? 40  LYS   A HD3  1 
ATOM   471  H HE2  . LYS   A 1 60  ? 29.221 22.983  12.348 1.00 83.62 ? 40  LYS   A HE2  1 
ATOM   472  H HE3  . LYS   A 1 60  ? 28.066 23.597  13.251 1.00 83.62 ? 40  LYS   A HE3  1 
ATOM   473  H HZ1  . LYS   A 1 60  ? 30.103 24.098  14.119 1.00 78.93 ? 40  LYS   A HZ1  1 
ATOM   474  H HZ2  . LYS   A 1 60  ? 29.399 23.256  15.063 1.00 78.93 ? 40  LYS   A HZ2  1 
ATOM   475  H HZ3  . LYS   A 1 60  ? 30.452 22.698  14.240 1.00 78.93 ? 40  LYS   A HZ3  1 
ATOM   476  N N    . ARG   A 1 61  ? 28.969 15.971  13.348 1.00 17.77 ? 41  ARG   A N    1 
ATOM   477  C CA   . ARG   A 1 61  ? 28.392 14.641  13.516 1.00 14.86 ? 41  ARG   A CA   1 
ATOM   478  C C    . ARG   A 1 61  ? 27.926 14.419  14.942 1.00 17.04 ? 41  ARG   A C    1 
ATOM   479  O O    . ARG   A 1 61  ? 27.025 13.613  15.189 1.00 15.07 ? 41  ARG   A O    1 
ATOM   480  C CB   . ARG   A 1 61  ? 29.403 13.573  13.112 1.00 14.69 ? 41  ARG   A CB   1 
ATOM   481  C CG   . ARG   A 1 61  ? 28.774 12.213  12.826 1.00 15.17 ? 41  ARG   A CG   1 
ATOM   482  C CD   . ARG   A 1 61  ? 29.816 11.207  12.357 1.00 14.69 ? 41  ARG   A CD   1 
ATOM   483  N NE   . ARG   A 1 61  ? 30.821 10.976  13.384 1.00 16.97 ? 41  ARG   A NE   1 
ATOM   484  C CZ   . ARG   A 1 61  ? 31.991 10.383  13.178 1.00 18.34 ? 41  ARG   A CZ   1 
ATOM   485  N NH1  . ARG   A 1 61  ? 32.334 9.925   11.987 1.00 20.39 ? 41  ARG   A NH1  1 
ATOM   486  N NH2  . ARG   A 1 61  ? 32.846 10.259  14.193 1.00 21.77 ? 41  ARG   A NH2  1 
ATOM   487  H H    . ARG   A 1 61  ? 29.804 15.981  13.142 1.00 21.33 ? 41  ARG   A H    1 
ATOM   488  H HA   . ARG   A 1 61  ? 27.623 14.555  12.930 1.00 17.85 ? 41  ARG   A HA   1 
ATOM   489  H HB2  . ARG   A 1 61  ? 29.860 13.864  12.307 1.00 17.64 ? 41  ARG   A HB2  1 
ATOM   490  H HB3  . ARG   A 1 61  ? 30.042 13.459  13.833 1.00 17.64 ? 41  ARG   A HB3  1 
ATOM   491  H HG2  . ARG   A 1 61  ? 28.363 11.872  13.636 1.00 18.22 ? 41  ARG   A HG2  1 
ATOM   492  H HG3  . ARG   A 1 61  ? 28.106 12.308  12.130 1.00 18.22 ? 41  ARG   A HG3  1 
ATOM   493  H HD2  . ARG   A 1 61  ? 29.382 10.363  12.158 1.00 17.64 ? 41  ARG   A HD2  1 
ATOM   494  H HD3  . ARG   A 1 61  ? 30.260 11.547  11.565 1.00 17.64 ? 41  ARG   A HD3  1 
ATOM   495  H HE   . ARG   A 1 61  ? 30.644 11.242  14.182 1.00 20.38 ? 41  ARG   A HE   1 
ATOM   496  H HH11 . ARG   A 1 61  ? 31.794 10.007  11.322 1.00 24.48 ? 41  ARG   A HH11 1 
ATOM   497  H HH12 . ARG   A 1 61  ? 33.097 9.544   11.876 1.00 24.48 ? 41  ARG   A HH12 1 
ATOM   498  H HH21 . ARG   A 1 61  ? 32.637 10.562  14.970 1.00 26.13 ? 41  ARG   A HH21 1 
ATOM   499  H HH22 . ARG   A 1 61  ? 33.606 9.877   14.070 1.00 26.13 ? 41  ARG   A HH22 1 
ATOM   500  N N    . HIS   A 1 62  ? 28.515 15.131  15.897 1.00 16.52 ? 42  HIS   A N    1 
ATOM   501  C CA   . HIS   A 1 62  ? 28.104 14.982  17.280 1.00 15.49 ? 42  HIS   A CA   1 
ATOM   502  C C    . HIS   A 1 62  ? 26.664 15.419  17.506 1.00 15.67 ? 42  HIS   A C    1 
ATOM   503  O O    . HIS   A 1 62  ? 26.064 15.039  18.516 1.00 15.98 ? 42  HIS   A O    1 
ATOM   504  C CB   . HIS   A 1 62  ? 29.037 15.784  18.193 1.00 17.51 ? 42  HIS   A CB   1 
ATOM   505  C CG   . HIS   A 1 62  ? 28.992 17.262  17.962 1.00 18.18 ? 42  HIS   A CG   1 
ATOM   506  N ND1  . HIS   A 1 62  ? 29.593 17.868  16.880 1.00 19.42 ? 42  HIS   A ND1  1 
ATOM   507  C CD2  . HIS   A 1 62  ? 28.420 18.257  18.680 1.00 19.40 ? 42  HIS   A CD2  1 
ATOM   508  C CE1  . HIS   A 1 62  ? 29.387 19.172  16.941 1.00 21.36 ? 42  HIS   A CE1  1 
ATOM   509  N NE2  . HIS   A 1 62  ? 28.680 19.434  18.026 1.00 20.35 ? 42  HIS   A NE2  1 
ATOM   510  H H    . HIS   A 1 62  ? 29.147 15.700  15.769 1.00 19.84 ? 42  HIS   A H    1 
ATOM   511  H HA   . HIS   A 1 62  ? 28.172 14.045  17.524 1.00 18.60 ? 42  HIS   A HA   1 
ATOM   512  H HB2  . HIS   A 1 62  ? 28.785 15.622  19.115 1.00 21.03 ? 42  HIS   A HB2  1 
ATOM   513  H HB3  . HIS   A 1 62  ? 29.949 15.489  18.041 1.00 21.03 ? 42  HIS   A HB3  1 
ATOM   514  H HD2  . HIS   A 1 62  ? 27.939 18.160  19.470 1.00 23.29 ? 42  HIS   A HD2  1 
ATOM   515  H HE1  . HIS   A 1 62  ? 29.689 19.799  16.324 1.00 25.64 ? 42  HIS   A HE1  1 
ATOM   516  H HE2  . HIS   A 1 62  ? 28.425 20.215  18.281 1.00 24.43 ? 42  HIS   A HE2  1 
ATOM   517  N N    . LEU   A 1 63  ? 26.089 16.200  16.591 1.00 16.64 ? 43  LEU   A N    1 
ATOM   518  C CA   . LEU   A 1 63  ? 24.700 16.608  16.752 1.00 17.84 ? 43  LEU   A CA   1 
ATOM   519  C C    . LEU   A 1 63  ? 23.729 15.465  16.501 1.00 19.11 ? 43  LEU   A C    1 
ATOM   520  O O    . LEU   A 1 63  ? 22.529 15.623  16.757 1.00 18.21 ? 43  LEU   A O    1 
ATOM   521  C CB   . LEU   A 1 63  ? 24.397 17.779  15.825 1.00 20.00 ? 43  LEU   A CB   1 
ATOM   522  C CG   . LEU   A 1 63  ? 25.242 19.013  16.121 1.00 23.34 ? 43  LEU   A CG   1 
ATOM   523  C CD1  . LEU   A 1 63  ? 24.931 20.097  15.109 1.00 25.40 ? 43  LEU   A CD1  1 
ATOM   524  C CD2  . LEU   A 1 63  ? 25.012 19.501  17.547 1.00 25.23 ? 43  LEU   A CD2  1 
ATOM   525  H H    . LEU   A 1 63  ? 26.477 16.499  15.884 1.00 19.98 ? 43  LEU   A H    1 
ATOM   526  H HA   . LEU   A 1 63  ? 24.560 16.914  17.661 1.00 21.42 ? 43  LEU   A HA   1 
ATOM   527  H HB2  . LEU   A 1 63  ? 24.573 17.508  14.910 1.00 24.02 ? 43  LEU   A HB2  1 
ATOM   528  H HB3  . LEU   A 1 63  ? 23.464 18.024  15.924 1.00 24.02 ? 43  LEU   A HB3  1 
ATOM   529  H HG   . LEU   A 1 63  ? 26.183 18.790  16.048 1.00 28.02 ? 43  LEU   A HG   1 
ATOM   530  H HD11 . LEU   A 1 63  ? 25.342 20.927  15.399 1.00 30.49 ? 43  LEU   A HD11 1 
ATOM   531  H HD12 . LEU   A 1 63  ? 25.288 19.835  14.246 1.00 30.49 ? 43  LEU   A HD12 1 
ATOM   532  H HD13 . LEU   A 1 63  ? 23.969 20.207  15.050 1.00 30.49 ? 43  LEU   A HD13 1 
ATOM   533  H HD21 . LEU   A 1 63  ? 25.322 20.417  17.622 1.00 30.29 ? 43  LEU   A HD21 1 
ATOM   534  H HD22 . LEU   A 1 63  ? 24.064 19.456  17.747 1.00 30.29 ? 43  LEU   A HD22 1 
ATOM   535  H HD23 . LEU   A 1 63  ? 25.506 18.933  18.159 1.00 30.29 ? 43  LEU   A HD23 1 
ATOM   536  N N    . LEU   A 1 64  ? 24.216 14.322  16.016 1.00 15.58 ? 44  LEU   A N    1 
ATOM   537  C CA   . LEU   A 1 64  ? 23.402 13.124  15.918 1.00 15.35 ? 44  LEU   A CA   1 
ATOM   538  C C    . LEU   A 1 64  ? 23.316 12.372  17.235 1.00 14.55 ? 44  LEU   A C    1 
ATOM   539  O O    . LEU   A 1 64  ? 22.650 11.331  17.296 1.00 15.55 ? 44  LEU   A O    1 
ATOM   540  C CB   . LEU   A 1 64  ? 23.968 12.207  14.829 1.00 15.08 ? 44  LEU   A CB   1 
ATOM   541  C CG   . LEU   A 1 64  ? 24.081 12.821  13.435 1.00 14.77 ? 44  LEU   A CG   1 
ATOM   542  C CD1  . LEU   A 1 64  ? 24.627 11.808  12.448 1.00 17.25 ? 44  LEU   A CD1  1 
ATOM   543  C CD2  . LEU   A 1 64  ? 22.733 13.359  12.994 1.00 19.64 ? 44  LEU   A CD2  1 
ATOM   544  H H    . LEU   A 1 64  ? 25.023 14.220  15.737 1.00 18.71 ? 44  LEU   A H    1 
ATOM   545  H HA   . LEU   A 1 64  ? 22.501 13.370  15.659 1.00 18.43 ? 44  LEU   A HA   1 
ATOM   546  H HB2  . LEU   A 1 64  ? 24.859 11.933  15.096 1.00 18.11 ? 44  LEU   A HB2  1 
ATOM   547  H HB3  . LEU   A 1 64  ? 23.390 11.431  14.756 1.00 18.11 ? 44  LEU   A HB3  1 
ATOM   548  H HG   . LEU   A 1 64  ? 24.704 13.564  13.456 1.00 17.74 ? 44  LEU   A HG   1 
ATOM   549  H HD11 . LEU   A 1 64  ? 24.403 12.091  11.548 1.00 20.72 ? 44  LEU   A HD11 1 
ATOM   550  H HD12 . LEU   A 1 64  ? 25.590 11.756  12.549 1.00 20.72 ? 44  LEU   A HD12 1 
ATOM   551  H HD13 . LEU   A 1 64  ? 24.229 10.942  12.631 1.00 20.72 ? 44  LEU   A HD13 1 
ATOM   552  H HD21 . LEU   A 1 64  ? 22.706 13.388  12.025 1.00 23.58 ? 44  LEU   A HD21 1 
ATOM   553  H HD22 . LEU   A 1 64  ? 22.035 12.774  13.327 1.00 23.58 ? 44  LEU   A HD22 1 
ATOM   554  H HD23 . LEU   A 1 64  ? 22.616 14.252  13.355 1.00 23.58 ? 44  LEU   A HD23 1 
ATOM   555  N N    . PHE   A 1 65  ? 23.967 12.875  18.276 1.00 13.75 ? 45  PHE   A N    1 
ATOM   556  C CA   . PHE   A 1 65  ? 24.006 12.232  19.580 1.00 12.41 ? 45  PHE   A CA   1 
ATOM   557  C C    . PHE   A 1 65  ? 23.105 12.954  20.577 1.00 16.83 ? 45  PHE   A C    1 
ATOM   558  O O    . PHE   A 1 65  ? 22.849 14.156  20.458 1.00 16.99 ? 45  PHE   A O    1 
ATOM   559  C CB   . PHE   A 1 65  ? 25.425 12.211  20.143 1.00 14.34 ? 45  PHE   A CB   1 
ATOM   560  C CG   . PHE   A 1 65  ? 26.337 11.230  19.477 1.00 15.00 ? 45  PHE   A CG   1 
ATOM   561  C CD1  . PHE   A 1 65  ? 26.879 11.510  18.242 1.00 15.45 ? 45  PHE   A CD1  1 
ATOM   562  C CD2  . PHE   A 1 65  ? 26.684 10.057  20.115 1.00 13.27 ? 45  PHE   A CD2  1 
ATOM   563  C CE1  . PHE   A 1 65  ? 27.736 10.616  17.635 1.00 15.13 ? 45  PHE   A CE1  1 
ATOM   564  C CE2  . PHE   A 1 65  ? 27.538 9.156   19.516 1.00 15.02 ? 45  PHE   A CE2  1 
ATOM   565  C CZ   . PHE   A 1 65  ? 28.065 9.445   18.282 1.00 15.22 ? 45  PHE   A CZ   1 
ATOM   566  H H    . PHE   A 1 65  ? 24.407 13.613  18.250 1.00 16.51 ? 45  PHE   A H    1 
ATOM   567  H HA   . PHE   A 1 65  ? 23.693 11.321  19.472 1.00 14.90 ? 45  PHE   A HA   1 
ATOM   568  H HB2  . PHE   A 1 65  ? 25.815 13.093  20.036 1.00 17.22 ? 45  PHE   A HB2  1 
ATOM   569  H HB3  . PHE   A 1 65  ? 25.382 11.979  21.084 1.00 17.22 ? 45  PHE   A HB3  1 
ATOM   570  H HD1  . PHE   A 1 65  ? 26.666 12.307  17.814 1.00 18.55 ? 45  PHE   A HD1  1 
ATOM   571  H HD2  . PHE   A 1 65  ? 26.338 9.873   20.958 1.00 15.93 ? 45  PHE   A HD2  1 
ATOM   572  H HE1  . PHE   A 1 65  ? 28.089 10.801  16.795 1.00 18.17 ? 45  PHE   A HE1  1 
ATOM   573  H HE2  . PHE   A 1 65  ? 27.756 8.360   19.944 1.00 18.03 ? 45  PHE   A HE2  1 
ATOM   574  H HZ   . PHE   A 1 65  ? 28.650 8.845   17.879 1.00 18.28 ? 45  PHE   A HZ   1 
ATOM   575  N N    . THR   A 1 66  ? 22.669 12.209  21.593 1.00 16.21 ? 46  THR   A N    1 
ATOM   576  C CA   . THR   A 1 66  ? 22.080 12.856  22.756 1.00 16.92 ? 46  THR   A CA   1 
ATOM   577  C C    . THR   A 1 66  ? 23.129 13.733  23.434 1.00 16.14 ? 46  THR   A C    1 
ATOM   578  O O    . THR   A 1 66  ? 24.335 13.582  23.227 1.00 17.25 ? 46  THR   A O    1 
ATOM   579  C CB   . THR   A 1 66  ? 21.548 11.818  23.725 1.00 16.93 ? 46  THR   A CB   1 
ATOM   580  O OG1  . THR   A 1 66  ? 22.630 11.007  24.202 1.00 17.28 ? 46  THR   A OG1  1 
ATOM   581  C CG2  . THR   A 1 66  ? 20.502 10.943  23.058 1.00 19.58 ? 46  THR   A CG2  1 
ATOM   582  H H    . THR   A 1 66  ? 22.703 11.350  21.630 1.00 19.47 ? 46  THR   A H    1 
ATOM   583  H HA   . THR   A 1 66  ? 21.334 13.416  22.490 1.00 20.31 ? 46  THR   A HA   1 
ATOM   584  H HB   . THR   A 1 66  ? 21.126 12.264  24.476 1.00 20.33 ? 46  THR   A HB   1 
ATOM   585  H HG1  . THR   A 1 66  ? 22.342 10.255  24.440 1.00 20.75 ? 46  THR   A HG1  1 
ATOM   586  H HG21 . THR   A 1 66  ? 20.020 10.433  23.728 1.00 23.51 ? 46  THR   A HG21 1 
ATOM   587  H HG22 . THR   A 1 66  ? 19.872 11.494  22.568 1.00 23.51 ? 46  THR   A HG22 1 
ATOM   588  H HG23 . THR   A 1 66  ? 20.929 10.328  22.441 1.00 23.51 ? 46  THR   A HG23 1 
ATOM   589  N N    . GLU   A 1 67  ? 22.661 14.664  24.267 1.00 18.80 ? 47  GLU   A N    1 
ATOM   590  C CA   . GLU   A 1 67  ? 23.595 15.550  24.955 1.00 21.17 ? 47  GLU   A CA   1 
ATOM   591  C C    . GLU   A 1 67  ? 24.619 14.755  25.753 1.00 18.23 ? 47  GLU   A C    1 
ATOM   592  O O    . GLU   A 1 67  ? 25.800 15.122  25.799 1.00 21.99 ? 47  GLU   A O    1 
ATOM   593  C CB   . GLU   A 1 67  ? 22.819 16.525  25.851 1.00 24.68 ? 47  GLU   A CB   1 
ATOM   594  C CG   . GLU   A 1 67  ? 22.221 17.684  25.060 1.00 67.50 ? 47  GLU   A CG   1 
ATOM   595  C CD   . GLU   A 1 67  ? 21.246 18.530  25.854 1.00 66.93 ? 47  GLU   A CD   1 
ATOM   596  O OE1  . GLU   A 1 67  ? 20.430 17.967  26.613 1.00 41.61 ? 47  GLU   A OE1  1 
ATOM   597  O OE2  . GLU   A 1 67  ? 21.287 19.769  25.705 1.00 40.98 ? 47  GLU   A OE2  1 
ATOM   598  H H    . GLU   A 1 67  ? 21.831 14.799  24.445 1.00 22.57 ? 47  GLU   A H    1 
ATOM   599  H HA   . GLU   A 1 67  ? 24.082 16.076  24.302 1.00 25.42 ? 47  GLU   A HA   1 
ATOM   600  H HB2  . GLU   A 1 67  ? 22.094 16.048  26.284 1.00 29.63 ? 47  GLU   A HB2  1 
ATOM   601  H HB3  . GLU   A 1 67  ? 23.421 16.891  26.517 1.00 29.63 ? 47  GLU   A HB3  1 
ATOM   602  H HG2  . GLU   A 1 67  ? 22.940 18.263  24.763 1.00 81.01 ? 47  GLU   A HG2  1 
ATOM   603  H HG3  . GLU   A 1 67  ? 21.745 17.327  24.294 1.00 81.01 ? 47  GLU   A HG3  1 
ATOM   604  N N    . ASP   A 1 68  ? 24.194 13.644  26.350 1.00 18.79 ? 48  ASP   A N    1 
ATOM   605  C CA   . ASP   A 1 68  ? 25.052 12.784  27.150 1.00 19.22 ? 48  ASP   A CA   1 
ATOM   606  C C    . ASP   A 1 68  ? 25.541 11.565  26.375 1.00 17.52 ? 48  ASP   A C    1 
ATOM   607  O O    . ASP   A 1 68  ? 25.986 10.584  26.984 1.00 20.48 ? 48  ASP   A O    1 
ATOM   608  C CB   . ASP   A 1 68  ? 24.315 12.334  28.412 1.00 23.50 ? 48  ASP   A CB   1 
ATOM   609  C CG   . ASP   A 1 68  ? 23.079 11.489  28.112 1.00 35.23 ? 48  ASP   A CG   1 
ATOM   610  O OD1  . ASP   A 1 68  ? 22.716 11.321  26.925 1.00 33.08 ? 48  ASP   A OD1  1 
ATOM   611  O OD2  . ASP   A 1 68  ? 22.468 10.990  29.078 1.00 46.17 ? 48  ASP   A OD2  1 
ATOM   612  H H    . ASP   A 1 68  ? 23.384 13.361  26.303 1.00 22.57 ? 48  ASP   A H    1 
ATOM   613  H HA   . ASP   A 1 68  ? 25.830 13.297  27.418 1.00 23.08 ? 48  ASP   A HA   1 
ATOM   614  H HB2  . ASP   A 1 68  ? 24.917 11.801  28.955 1.00 28.21 ? 48  ASP   A HB2  1 
ATOM   615  H HB3  . ASP   A 1 68  ? 24.029 13.118  28.906 1.00 28.21 ? 48  ASP   A HB3  1 
ATOM   616  N N    . GLY   A 1 69  ? 25.445 11.606  25.054 1.00 17.29 ? 49  GLY   A N    1 
ATOM   617  C CA   . GLY   A 1 69  ? 25.802 10.456  24.258 1.00 17.91 ? 49  GLY   A CA   1 
ATOM   618  C C    . GLY   A 1 69  ? 27.282 10.147  24.320 1.00 17.05 ? 49  GLY   A C    1 
ATOM   619  O O    . GLY   A 1 69  ? 28.134 11.007  24.576 1.00 19.05 ? 49  GLY   A O    1 
ATOM   620  H H    . GLY   A 1 69  ? 25.176 12.286  24.601 1.00 20.76 ? 49  GLY   A H    1 
ATOM   621  H HA2  . GLY   A 1 69  ? 25.315 9.680   24.577 1.00 21.50 ? 49  GLY   A HA2  1 
ATOM   622  H HA3  . GLY   A 1 69  ? 25.563 10.619  23.332 1.00 21.50 ? 49  GLY   A HA3  1 
ATOM   623  N N    . VAL   A 1 70  ? 27.586 8.877   24.058 1.00 14.24 ? 50  VAL   A N    1 
ATOM   624  C CA   . VAL   A 1 70  ? 28.937 8.352   24.137 1.00 14.89 ? 50  VAL   A CA   1 
ATOM   625  C C    . VAL   A 1 70  ? 29.301 7.781   22.781 1.00 13.59 ? 50  VAL   A C    1 
ATOM   626  O O    . VAL   A 1 70  ? 28.489 7.099   22.149 1.00 15.18 ? 50  VAL   A O    1 
ATOM   627  C CB   . VAL   A 1 70  ? 29.072 7.268   25.222 1.00 17.90 ? 50  VAL   A CB   1 
ATOM   628  C CG1  . VAL   A 1 70  ? 30.469 6.655   25.164 1.00 21.88 ? 50  VAL   A CG1  1 
ATOM   629  C CG2  . VAL   A 1 70  ? 28.783 7.848   26.590 1.00 19.23 ? 50  VAL   A CG2  1 
ATOM   630  H H    . VAL   A 1 70  ? 27.005 8.287   23.827 1.00 17.10 ? 50  VAL   A H    1 
ATOM   631  H HA   . VAL   A 1 70  ? 29.546 9.076   24.353 1.00 17.88 ? 50  VAL   A HA   1 
ATOM   632  H HB   . VAL   A 1 70  ? 28.424 6.564   25.062 1.00 21.49 ? 50  VAL   A HB   1 
ATOM   633  H HG11 . VAL   A 1 70  ? 30.578 6.047   25.912 1.00 26.27 ? 50  VAL   A HG11 1 
ATOM   634  H HG12 . VAL   A 1 70  ? 30.568 6.173   24.328 1.00 26.27 ? 50  VAL   A HG12 1 
ATOM   635  H HG13 . VAL   A 1 70  ? 31.128 7.365   25.217 1.00 26.27 ? 50  VAL   A HG13 1 
ATOM   636  H HG21 . VAL   A 1 70  ? 28.847 7.142   27.252 1.00 23.09 ? 50  VAL   A HG21 1 
ATOM   637  H HG22 . VAL   A 1 70  ? 29.432 8.542   26.782 1.00 23.09 ? 50  VAL   A HG22 1 
ATOM   638  H HG23 . VAL   A 1 70  ? 27.888 8.222   26.591 1.00 23.09 ? 50  VAL   A HG23 1 
ATOM   639  N N    . GLY   A 1 71  ? 30.520 8.064   22.340 1.00 13.99 ? 51  GLY   A N    1 
ATOM   640  C CA   . GLY   A 1 71  ? 31.048 7.454   21.140 1.00 12.94 ? 51  GLY   A CA   1 
ATOM   641  C C    . GLY   A 1 71  ? 32.469 7.000   21.389 1.00 16.98 ? 51  GLY   A C    1 
ATOM   642  O O    . GLY   A 1 71  ? 33.062 7.315   22.420 1.00 21.00 ? 51  GLY   A O    1 
ATOM   643  H H    . GLY   A 1 71  ? 31.062 8.611   22.724 1.00 16.80 ? 51  GLY   A H    1 
ATOM   644  H HA2  . GLY   A 1 71  ? 30.508 6.686   20.893 1.00 15.54 ? 51  GLY   A HA2  1 
ATOM   645  H HA3  . GLY   A 1 71  ? 31.041 8.093   20.411 1.00 15.54 ? 51  GLY   A HA3  1 
ATOM   646  N N    . GLY   A 1 72  ? 33.002 6.247   20.448 1.00 15.13 ? 52  GLY   A N    1 
ATOM   647  C CA   . GLY   A 1 72  ? 34.429 6.034   20.429 1.00 14.35 ? 52  GLY   A CA   1 
ATOM   648  C C    . GLY   A 1 72  ? 34.797 4.639   19.983 1.00 15.99 ? 52  GLY   A C    1 
ATOM   649  O O    . GLY   A 1 72  ? 34.005 3.920   19.392 1.00 16.56 ? 52  GLY   A O    1 
ATOM   650  H H    . GLY   A 1 72  ? 32.563 5.855   19.821 1.00 18.17 ? 52  GLY   A H    1 
ATOM   651  H HA2  . GLY   A 1 72  ? 34.840 6.667   19.820 1.00 17.23 ? 52  GLY   A HA2  1 
ATOM   652  H HA3  . GLY   A 1 72  ? 34.787 6.173   21.319 1.00 17.23 ? 52  GLY   A HA3  1 
ATOM   653  N N    . LEU   A 1 73  ? 36.040 4.299   20.287 1.00 18.10 ? 53  LEU   A N    1 
ATOM   654  C CA   . LEU   A 1 73  ? 36.703 3.112   19.759 1.00 15.95 ? 53  LEU   A CA   1 
ATOM   655  C C    . LEU   A 1 73  ? 36.805 2.079   20.864 1.00 15.25 ? 53  LEU   A C    1 
ATOM   656  O O    . LEU   A 1 73  ? 37.419 2.328   21.906 1.00 16.84 ? 53  LEU   A O    1 
ATOM   657  C CB   . LEU   A 1 73  ? 38.085 3.469   19.229 1.00 14.03 ? 53  LEU   A CB   1 
ATOM   658  C CG   . LEU   A 1 73  ? 38.958 2.286   18.814 1.00 15.15 ? 53  LEU   A CG   1 
ATOM   659  C CD1  . LEU   A 1 73  ? 38.388 1.574   17.612 1.00 16.63 ? 53  LEU   A CD1  1 
ATOM   660  C CD2  . LEU   A 1 73  ? 40.346 2.836   18.543 1.00 16.45 ? 53  LEU   A CD2  1 
ATOM   661  H H    . LEU   A 1 73  ? 36.540 4.756   20.816 1.00 21.73 ? 53  LEU   A H    1 
ATOM   662  H HA   . LEU   A 1 73  ? 36.178 2.734   19.035 1.00 19.16 ? 53  LEU   A HA   1 
ATOM   663  H HB2  . LEU   A 1 73  ? 37.974 4.034   18.448 1.00 16.85 ? 53  LEU   A HB2  1 
ATOM   664  H HB3  . LEU   A 1 73  ? 38.562 3.950   19.923 1.00 16.85 ? 53  LEU   A HB3  1 
ATOM   665  H HG   . LEU   A 1 73  ? 38.998 1.614   19.513 1.00 18.19 ? 53  LEU   A HG   1 
ATOM   666  H HD11 . LEU   A 1 73  ? 38.948 0.810   17.403 1.00 19.97 ? 53  LEU   A HD11 1 
ATOM   667  H HD12 . LEU   A 1 73  ? 37.488 1.278   17.818 1.00 19.97 ? 53  LEU   A HD12 1 
ATOM   668  H HD13 . LEU   A 1 73  ? 38.371 2.187   16.861 1.00 19.97 ? 53  LEU   A HD13 1 
ATOM   669  H HD21 . LEU   A 1 73  ? 40.911 2.119   18.213 1.00 19.75 ? 53  LEU   A HD21 1 
ATOM   670  H HD22 . LEU   A 1 73  ? 40.283 3.539   17.878 1.00 19.75 ? 53  LEU   A HD22 1 
ATOM   671  H HD23 . LEU   A 1 73  ? 40.711 3.192   19.368 1.00 19.75 ? 53  LEU   A HD23 1 
ATOM   672  N N    . TRP   A 1 74  ? 36.207 0.919   20.635 1.00 15.69 ? 54  TRP   A N    1 
ATOM   673  C CA   . TRP   A 1 74  ? 36.129 -0.116  21.648 1.00 15.36 ? 54  TRP   A CA   1 
ATOM   674  C C    . TRP   A 1 74  ? 37.225 -1.167  21.522 1.00 16.84 ? 54  TRP   A C    1 
ATOM   675  O O    . TRP   A 1 74  ? 37.360 -2.006  22.419 1.00 24.19 ? 54  TRP   A O    1 
ATOM   676  C CB   . TRP   A 1 74  ? 34.751 -0.771  21.606 1.00 16.33 ? 54  TRP   A CB   1 
ATOM   677  C CG   . TRP   A 1 74  ? 33.917 -0.332  22.764 1.00 15.28 ? 54  TRP   A CG   1 
ATOM   678  C CD1  . TRP   A 1 74  ? 33.469 -1.109  23.781 1.00 18.27 ? 54  TRP   A CD1  1 
ATOM   679  C CD2  . TRP   A 1 74  ? 33.480 1.007   23.050 1.00 15.49 ? 54  TRP   A CD2  1 
ATOM   680  N NE1  . TRP   A 1 74  ? 32.758 -0.344  24.681 1.00 18.98 ? 54  TRP   A NE1  1 
ATOM   681  C CE2  . TRP   A 1 74  ? 32.753 0.957   24.258 1.00 16.49 ? 54  TRP   A CE2  1 
ATOM   682  C CE3  . TRP   A 1 74  ? 33.625 2.235   22.402 1.00 17.37 ? 54  TRP   A CE3  1 
ATOM   683  C CZ2  . TRP   A 1 74  ? 32.174 2.088   24.827 1.00 17.21 ? 54  TRP   A CZ2  1 
ATOM   684  C CZ3  . TRP   A 1 74  ? 33.048 3.364   22.969 1.00 18.00 ? 54  TRP   A CZ3  1 
ATOM   685  C CH2  . TRP   A 1 74  ? 32.335 3.277   24.168 1.00 18.35 ? 54  TRP   A CH2  1 
ATOM   686  H H    . TRP   A 1 74  ? 35.834 0.707   19.890 1.00 18.84 ? 54  TRP   A H    1 
ATOM   687  H HA   . TRP   A 1 74  ? 36.233 0.286   22.525 1.00 18.45 ? 54  TRP   A HA   1 
ATOM   688  H HB2  . TRP   A 1 74  ? 34.298 -0.517  20.786 1.00 19.60 ? 54  TRP   A HB2  1 
ATOM   689  H HB3  . TRP   A 1 74  ? 34.850 -1.735  21.646 1.00 19.60 ? 54  TRP   A HB3  1 
ATOM   690  H HD1  . TRP   A 1 74  ? 33.619 -2.024  23.859 1.00 21.94 ? 54  TRP   A HD1  1 
ATOM   691  H HE1  . TRP   A 1 74  ? 32.379 -0.637  25.395 1.00 22.79 ? 54  TRP   A HE1  1 
ATOM   692  H HE3  . TRP   A 1 74  ? 34.099 2.295   21.604 1.00 20.86 ? 54  TRP   A HE3  1 
ATOM   693  H HZ2  . TRP   A 1 74  ? 31.696 2.037   25.623 1.00 20.67 ? 54  TRP   A HZ2  1 
ATOM   694  H HZ3  . TRP   A 1 74  ? 33.138 4.187   22.547 1.00 21.61 ? 54  TRP   A HZ3  1 
ATOM   695  H HH2  . TRP   A 1 74  ? 31.959 4.048   24.527 1.00 22.03 ? 54  TRP   A HH2  1 
ATOM   696  N N    . THR   A 1 75  ? 38.031 -1.115  20.469 1.00 15.33 ? 55  THR   A N    1 
ATOM   697  C CA   . THR   A 1 75  ? 39.093 -2.088  20.216 1.00 15.35 ? 55  THR   A CA   1 
ATOM   698  C C    . THR   A 1 75  ? 40.396 -1.309  20.116 1.00 15.07 ? 55  THR   A C    1 
ATOM   699  O O    . THR   A 1 75  ? 40.715 -0.750  19.068 1.00 17.00 ? 55  THR   A O    1 
ATOM   700  C CB   . THR   A 1 75  ? 38.812 -2.870  18.949 1.00 14.22 ? 55  THR   A CB   1 
ATOM   701  O OG1  . THR   A 1 75  ? 38.500 -1.947  17.911 1.00 14.43 ? 55  THR   A OG1  1 
ATOM   702  C CG2  . THR   A 1 75  ? 37.655 -3.819  19.152 1.00 13.07 ? 55  THR   A CG2  1 
ATOM   703  H H    . THR   A 1 75  ? 37.983 -0.505  19.865 1.00 18.40 ? 55  THR   A H    1 
ATOM   704  H HA   . THR   A 1 75  ? 39.157 -2.715  20.953 1.00 18.43 ? 55  THR   A HA   1 
ATOM   705  H HB   . THR   A 1 75  ? 39.586 -3.400  18.702 1.00 17.07 ? 55  THR   A HB   1 
ATOM   706  H HG1  . THR   A 1 75  ? 39.163 -1.455  17.755 1.00 17.33 ? 55  THR   A HG1  1 
ATOM   707  H HG21 . THR   A 1 75  ? 37.407 -4.225  18.307 1.00 15.69 ? 55  THR   A HG21 1 
ATOM   708  H HG22 . THR   A 1 75  ? 37.904 -4.518  19.777 1.00 15.69 ? 55  THR   A HG22 1 
ATOM   709  H HG23 . THR   A 1 75  ? 36.890 -3.338  19.506 1.00 15.69 ? 55  THR   A HG23 1 
ATOM   710  N N    . THR   A 1 76  ? 41.139 -1.261  21.214 1.00 17.27 ? 56  THR   A N    1 
ATOM   711  C CA   . THR   A 1 76  ? 42.369 -0.495  21.297 1.00 16.31 ? 56  THR   A CA   1 
ATOM   712  C C    . THR   A 1 76  ? 43.504 -1.426  21.695 1.00 16.82 ? 56  THR   A C    1 
ATOM   713  O O    . THR   A 1 76  ? 43.283 -2.525  22.202 1.00 18.33 ? 56  THR   A O    1 
ATOM   714  C CB   . THR   A 1 76  ? 42.259 0.624   22.326 1.00 21.83 ? 56  THR   A CB   1 
ATOM   715  O OG1  . THR   A 1 76  ? 42.136 0.040   23.618 1.00 21.74 ? 56  THR   A OG1  1 
ATOM   716  C CG2  . THR   A 1 76  ? 41.058 1.511   22.045 1.00 25.58 ? 56  THR   A CG2  1 
ATOM   717  H H    . THR   A 1 76  ? 40.943 -1.676  21.941 1.00 20.74 ? 56  THR   A H    1 
ATOM   718  H HA   . THR   A 1 76  ? 42.557 -0.099  20.431 1.00 19.58 ? 56  THR   A HA   1 
ATOM   719  H HB   . THR   A 1 76  ? 43.048 1.187   22.289 1.00 26.21 ? 56  THR   A HB   1 
ATOM   720  H HG1  . THR   A 1 76  ? 42.182 0.636   24.209 1.00 26.10 ? 56  THR   A HG1  1 
ATOM   721  H HG21 . THR   A 1 76  ? 40.965 2.175   22.745 1.00 30.71 ? 56  THR   A HG21 1 
ATOM   722  H HG22 . THR   A 1 76  ? 41.171 1.963   21.195 1.00 30.71 ? 56  THR   A HG22 1 
ATOM   723  H HG23 . THR   A 1 76  ? 40.250 0.974   22.011 1.00 30.71 ? 56  THR   A HG23 1 
ATOM   724  N N    . ASP   A 1 77  ? 44.740 -0.965  21.516 1.00 18.31 ? 57  ASP   A N    1 
ATOM   725  C CA   . ASP   A 1 77  ? 45.859 -1.818  21.893 1.00 17.66 ? 57  ASP   A CA   1 
ATOM   726  C C    . ASP   A 1 77  ? 45.912 -2.014  23.401 1.00 21.55 ? 57  ASP   A C    1 
ATOM   727  O O    . ASP   A 1 77  ? 46.392 -3.050  23.873 1.00 23.23 ? 57  ASP   A O    1 
ATOM   728  C CB   . ASP   A 1 77  ? 47.186 -1.254  21.370 1.00 20.65 ? 57  ASP   A CB   1 
ATOM   729  C CG   . ASP   A 1 77  ? 47.556 0.078   21.986 1.00 28.55 ? 57  ASP   A CG   1 
ATOM   730  O OD1  . ASP   A 1 77  ? 47.938 0.101   23.174 1.00 28.48 ? 57  ASP   A OD1  1 
ATOM   731  O OD2  . ASP   A 1 77  ? 47.486 1.088   21.270 1.00 28.49 ? 57  ASP   A OD2  1 
ATOM   732  H H    . ASP   A 1 77  ? 44.947 -0.196  21.192 1.00 21.98 ? 57  ASP   A H    1 
ATOM   733  H HA   . ASP   A 1 77  ? 45.742 -2.686  21.474 1.00 21.21 ? 57  ASP   A HA   1 
ATOM   734  H HB2  . ASP   A 1 77  ? 47.896 -1.882  21.574 1.00 24.79 ? 57  ASP   A HB2  1 
ATOM   735  H HB3  . ASP   A 1 77  ? 47.117 -1.129  20.411 1.00 24.79 ? 57  ASP   A HB3  1 
ATOM   736  N N    . SER   A 1 78  ? 45.404 -1.049  24.172 1.00 20.62 ? 58  SER   A N    1 
ATOM   737  C CA   . SER   A 1 78  ? 45.415 -1.172  25.624 1.00 24.01 ? 58  SER   A CA   1 
ATOM   738  C C    . SER   A 1 78  ? 44.332 -2.103  26.134 1.00 21.73 ? 58  SER   A C    1 
ATOM   739  O O    . SER   A 1 78  ? 44.399 -2.538  27.288 1.00 27.21 ? 58  SER   A O    1 
ATOM   740  C CB   . SER   A 1 78  ? 45.239 0.203   26.282 1.00 29.99 ? 58  SER   A CB   1 
ATOM   741  O OG   . SER   A 1 78  ? 43.893 0.639   26.182 1.00 27.03 ? 58  SER   A OG   1 
ATOM   742  H H    . SER   A 1 78  ? 45.051 -0.321  23.878 1.00 24.76 ? 58  SER   A H    1 
ATOM   743  H HA   . SER   A 1 78  ? 46.278 -1.526  25.891 1.00 28.83 ? 58  SER   A HA   1 
ATOM   744  H HB2  . SER   A 1 78  ? 45.482 0.139   27.219 1.00 36.00 ? 58  SER   A HB2  1 
ATOM   745  H HB3  . SER   A 1 78  ? 45.813 0.844   25.834 1.00 36.00 ? 58  SER   A HB3  1 
ATOM   746  H HG   . SER   A 1 78  ? 43.753 0.966   25.421 1.00 32.45 ? 58  SER   A HG   1 
ATOM   747  N N    . GLY   A 1 79  ? 43.340 -2.416  25.309 1.00 21.92 ? 59  GLY   A N    1 
ATOM   748  C CA   . GLY   A 1 79  ? 42.203 -3.190  25.734 1.00 23.33 ? 59  GLY   A CA   1 
ATOM   749  C C    . GLY   A 1 79  ? 41.087 -2.374  26.346 1.00 25.93 ? 59  GLY   A C    1 
ATOM   750  O O    . GLY   A 1 79  ? 39.979 -2.901  26.529 1.00 34.52 ? 59  GLY   A O    1 
ATOM   751  H H    . GLY   A 1 79  ? 43.309 -2.182  24.482 1.00 26.32 ? 59  GLY   A H    1 
ATOM   752  H HA2  . GLY   A 1 79  ? 41.842 -3.662  24.968 1.00 28.00 ? 59  GLY   A HA2  1 
ATOM   753  H HA3  . GLY   A 1 79  ? 42.495 -3.838  26.395 1.00 28.00 ? 59  GLY   A HA3  1 
ATOM   754  N N    . GLN   A 1 80  ? 41.339 -1.108  26.662 1.00 21.75 ? 60  GLN   A N    1 
ATOM   755  C CA   . GLN   A 1 80  ? 40.304 -0.241  27.205 1.00 24.64 ? 60  GLN   A CA   1 
ATOM   756  C C    . GLN   A 1 80  ? 39.742 0.662   26.116 1.00 19.72 ? 60  GLN   A C    1 
ATOM   757  O O    . GLN   A 1 80  ? 40.508 1.226   25.321 1.00 23.45 ? 60  GLN   A O    1 
ATOM   758  C CB   . GLN   A 1 80  ? 40.860 0.628   28.331 1.00 31.69 ? 60  GLN   A CB   1 
ATOM   759  C CG   . GLN   A 1 80  ? 41.312 -0.156  29.541 1.00 51.39 ? 60  GLN   A CG   1 
ATOM   760  C CD   . GLN   A 1 80  ? 40.203 -1.002  30.127 1.00 57.34 ? 60  GLN   A CD   1 
ATOM   761  O OE1  . GLN   A 1 80  ? 40.393 -2.184  30.404 1.00 55.12 ? 60  GLN   A OE1  1 
ATOM   762  N NE2  . GLN   A 1 80  ? 39.036 -0.399  30.322 1.00 48.40 ? 60  GLN   A NE2  1 
ATOM   763  H H    . GLN   A 1 80  ? 42.103 -0.726  26.570 1.00 26.12 ? 60  GLN   A H    1 
ATOM   764  H HA   . GLN   A 1 80  ? 39.585 -0.784  27.566 1.00 29.59 ? 60  GLN   A HA   1 
ATOM   765  H HB2  . GLN   A 1 80  ? 41.625 1.120   27.996 1.00 38.04 ? 60  GLN   A HB2  1 
ATOM   766  H HB3  . GLN   A 1 80  ? 40.169 1.244   28.619 1.00 38.04 ? 60  GLN   A HB3  1 
ATOM   767  H HG2  . GLN   A 1 80  ? 42.037 -0.746  29.284 1.00 61.68 ? 60  GLN   A HG2  1 
ATOM   768  H HG3  . GLN   A 1 80  ? 41.613 0.462   30.225 1.00 61.68 ? 60  GLN   A HG3  1 
ATOM   769  H HE21 . GLN   A 1 80  ? 38.941 0.431   30.118 1.00 58.09 ? 60  GLN   A HE21 1 
ATOM   770  H HE22 . GLN   A 1 80  ? 38.375 -0.839  30.654 1.00 58.09 ? 60  GLN   A HE22 1 
ATOM   771  N N    . PRO   A 1 81  ? 38.422 0.822   26.047 1.00 23.46 ? 61  PRO   A N    1 
ATOM   772  C CA   . PRO   A 1 81  ? 37.857 1.719   25.033 1.00 20.60 ? 61  PRO   A CA   1 
ATOM   773  C C    . PRO   A 1 81  ? 38.345 3.150   25.192 1.00 22.39 ? 61  PRO   A C    1 
ATOM   774  O O    . PRO   A 1 81  ? 38.627 3.622   26.299 1.00 23.71 ? 61  PRO   A O    1 
ATOM   775  C CB   . PRO   A 1 81  ? 36.343 1.619   25.270 1.00 23.62 ? 61  PRO   A CB   1 
ATOM   776  C CG   . PRO   A 1 81  ? 36.148 0.268   25.888 1.00 27.29 ? 61  PRO   A CG   1 
ATOM   777  C CD   . PRO   A 1 81  ? 37.374 0.057   26.752 1.00 24.95 ? 61  PRO   A CD   1 
ATOM   778  H HA   . PRO   A 1 81  ? 38.079 1.401   24.144 1.00 24.73 ? 61  PRO   A HA   1 
ATOM   779  H HB2  . PRO   A 1 81  ? 36.055 2.322   25.872 1.00 28.36 ? 61  PRO   A HB2  1 
ATOM   780  H HB3  . PRO   A 1 81  ? 35.870 1.688   24.427 1.00 28.36 ? 61  PRO   A HB3  1 
ATOM   781  H HG2  . PRO   A 1 81  ? 35.340 0.263   26.424 1.00 32.76 ? 61  PRO   A HG2  1 
ATOM   782  H HG3  . PRO   A 1 81  ? 36.090 -0.408  25.195 1.00 32.76 ? 61  PRO   A HG3  1 
ATOM   783  H HD2  . PRO   A 1 81  ? 37.231 0.408   27.644 1.00 29.95 ? 61  PRO   A HD2  1 
ATOM   784  H HD3  . PRO   A 1 81  ? 37.605 -0.884  26.798 1.00 29.95 ? 61  PRO   A HD3  1 
ATOM   785  N N    . ILE   A 1 82  ? 38.459 3.837   24.057 1.00 18.22 ? 62  ILE   A N    1 
ATOM   786  C CA   . ILE   A 1 82  ? 38.561 5.290   24.026 1.00 19.87 ? 62  ILE   A CA   1 
ATOM   787  C C    . ILE   A 1 82  ? 37.119 5.778   23.934 1.00 20.14 ? 62  ILE   A C    1 
ATOM   788  O O    . ILE   A 1 82  ? 36.532 5.829   22.850 1.00 20.93 ? 62  ILE   A O    1 
ATOM   789  C CB   . ILE   A 1 82  ? 39.417 5.781   22.861 1.00 23.98 ? 62  ILE   A CB   1 
ATOM   790  C CG1  . ILE   A 1 82  ? 40.856 5.293   23.048 1.00 25.49 ? 62  ILE   A CG1  1 
ATOM   791  C CG2  . ILE   A 1 82  ? 39.410 7.296   22.776 1.00 24.04 ? 62  ILE   A CG2  1 
ATOM   792  C CD1  . ILE   A 1 82  ? 41.753 5.540   21.863 1.00 30.32 ? 62  ILE   A CD1  1 
ATOM   793  H H    . ILE   A 1 82  ? 38.480 3.474   23.277 1.00 21.88 ? 62  ILE   A H    1 
ATOM   794  H HA   . ILE   A 1 82  ? 38.970 5.625   24.840 1.00 23.85 ? 62  ILE   A HA   1 
ATOM   795  H HB   . ILE   A 1 82  ? 39.044 5.424   22.040 1.00 28.79 ? 62  ILE   A HB   1 
ATOM   796  H HG12 . ILE   A 1 82  ? 41.243 5.752   23.810 1.00 30.60 ? 62  ILE   A HG12 1 
ATOM   797  H HG13 . ILE   A 1 82  ? 40.840 4.336   23.210 1.00 30.60 ? 62  ILE   A HG13 1 
ATOM   798  H HG21 . ILE   A 1 82  ? 39.781 7.566   21.921 1.00 28.86 ? 62  ILE   A HG21 1 
ATOM   799  H HG22 . ILE   A 1 82  ? 38.497 7.612   22.856 1.00 28.86 ? 62  ILE   A HG22 1 
ATOM   800  H HG23 . ILE   A 1 82  ? 39.949 7.655   23.498 1.00 28.86 ? 62  ILE   A HG23 1 
ATOM   801  H HD11 . ILE   A 1 82  ? 42.591 5.070   21.998 1.00 36.39 ? 62  ILE   A HD11 1 
ATOM   802  H HD12 . ILE   A 1 82  ? 41.315 5.213   21.062 1.00 36.39 ? 62  ILE   A HD12 1 
ATOM   803  H HD13 . ILE   A 1 82  ? 41.918 6.493   21.785 1.00 36.39 ? 62  ILE   A HD13 1 
ATOM   804  N N    . ALA   A 1 83  ? 36.528 6.073   25.086 1.00 21.02 ? 63  ALA   A N    1 
ATOM   805  C CA   . ALA   A 1 83  ? 35.126 6.454   25.193 1.00 20.70 ? 63  ALA   A CA   1 
ATOM   806  C C    . ALA   A 1 83  ? 35.056 7.968   25.300 1.00 25.23 ? 63  ALA   A C    1 
ATOM   807  O O    . ALA   A 1 83  ? 35.686 8.560   26.185 1.00 23.08 ? 63  ALA   A O    1 
ATOM   808  C CB   . ALA   A 1 83  ? 34.474 5.783   26.402 1.00 22.08 ? 63  ALA   A CB   1 
ATOM   809  H H    . ALA   A 1 83  ? 36.933 6.059   25.844 1.00 25.24 ? 63  ALA   A H    1 
ATOM   810  H HA   . ALA   A 1 83  ? 34.639 6.175   24.402 1.00 24.85 ? 63  ALA   A HA   1 
ATOM   811  H HB1  . ALA   A 1 83  ? 33.549 6.071   26.462 1.00 26.50 ? 63  ALA   A HB1  1 
ATOM   812  H HB2  . ALA   A 1 83  ? 34.513 4.821   26.289 1.00 26.50 ? 63  ALA   A HB2  1 
ATOM   813  H HB3  . ALA   A 1 83  ? 34.954 6.042   27.204 1.00 26.50 ? 63  ALA   A HB3  1 
ATOM   814  N N    . ILE   A 1 84  ? 34.315 8.586   24.382 1.00 16.89 ? 64  ILE   A N    1 
ATOM   815  C CA   . ILE   A 1 84  ? 34.164 10.033  24.304 1.00 15.43 ? 64  ILE   A CA   1 
ATOM   816  C C    . ILE   A 1 84  ? 32.766 10.339  24.817 1.00 17.91 ? 64  ILE   A C    1 
ATOM   817  O O    . ILE   A 1 84  ? 31.772 9.915   24.220 1.00 16.99 ? 64  ILE   A O    1 
ATOM   818  C CB   . ILE   A 1 84  ? 34.368 10.540  22.874 1.00 17.38 ? 64  ILE   A CB   1 
ATOM   819  C CG1  . ILE   A 1 84  ? 35.702 9.988   22.332 1.00 26.22 ? 64  ILE   A CG1  1 
ATOM   820  C CG2  . ILE   A 1 84  ? 34.354 12.052  22.849 1.00 23.23 ? 64  ILE   A CG2  1 
ATOM   821  C CD1  . ILE   A 1 84  ? 35.701 9.752   20.836 1.00 31.98 ? 64  ILE   A CD1  1 
ATOM   822  H H    . ILE   A 1 84  ? 33.875 8.171   23.772 1.00 20.28 ? 64  ILE   A H    1 
ATOM   823  H HA   . ILE   A 1 84  ? 34.814 10.481  24.867 1.00 18.53 ? 64  ILE   A HA   1 
ATOM   824  H HB   . ILE   A 1 84  ? 33.644 10.227  22.309 1.00 20.87 ? 64  ILE   A HB   1 
ATOM   825  H HG12 . ILE   A 1 84  ? 36.407 10.624  22.531 1.00 31.48 ? 64  ILE   A HG12 1 
ATOM   826  H HG13 . ILE   A 1 84  ? 35.888 9.140   22.766 1.00 31.48 ? 64  ILE   A HG13 1 
ATOM   827  H HG21 . ILE   A 1 84  ? 34.556 12.355  21.950 1.00 27.89 ? 64  ILE   A HG21 1 
ATOM   828  H HG22 . ILE   A 1 84  ? 33.474 12.364  23.113 1.00 27.89 ? 64  ILE   A HG22 1 
ATOM   829  H HG23 . ILE   A 1 84  ? 35.023 12.384  23.468 1.00 27.89 ? 64  ILE   A HG23 1 
ATOM   830  H HD11 . ILE   A 1 84  ? 36.596 9.507   20.555 1.00 38.39 ? 64  ILE   A HD11 1 
ATOM   831  H HD12 . ILE   A 1 84  ? 35.082 9.034   20.630 1.00 38.39 ? 64  ILE   A HD12 1 
ATOM   832  H HD13 . ILE   A 1 84  ? 35.425 10.566  20.388 1.00 38.39 ? 64  ILE   A HD13 1 
ATOM   833  N N    A ARG   A 1 85  ? 32.677 11.080  25.920 0.53 18.64 ? 65  ARG   A N    1 
ATOM   834  N N    B ARG   A 1 85  ? 32.685 11.056  25.935 0.47 18.63 ? 65  ARG   A N    1 
ATOM   835  C CA   A ARG   A 1 85  ? 31.438 11.165  26.689 0.53 16.95 ? 65  ARG   A CA   1 
ATOM   836  C CA   B ARG   A 1 85  ? 31.447 11.172  26.697 0.47 16.95 ? 65  ARG   A CA   1 
ATOM   837  C C    A ARG   A 1 85  ? 30.846 12.567  26.624 0.53 19.66 ? 65  ARG   A C    1 
ATOM   838  C C    B ARG   A 1 85  ? 30.872 12.580  26.580 0.47 19.70 ? 65  ARG   A C    1 
ATOM   839  O O    A ARG   A 1 85  ? 31.398 13.515  27.195 0.53 19.90 ? 65  ARG   A O    1 
ATOM   840  O O    B ARG   A 1 85  ? 31.469 13.548  27.066 0.47 20.20 ? 65  ARG   A O    1 
ATOM   841  C CB   A ARG   A 1 85  ? 31.685 10.759  28.140 0.53 23.02 ? 65  ARG   A CB   1 
ATOM   842  C CB   B ARG   A 1 85  ? 31.674 10.825  28.172 0.47 23.03 ? 65  ARG   A CB   1 
ATOM   843  C CG   A ARG   A 1 85  ? 32.305 9.387   28.289 0.53 28.05 ? 65  ARG   A CG   1 
ATOM   844  C CG   B ARG   A 1 85  ? 32.040 9.370   28.451 0.47 26.33 ? 65  ARG   A CG   1 
ATOM   845  C CD   A ARG   A 1 85  ? 32.566 9.051   29.741 0.53 30.14 ? 65  ARG   A CD   1 
ATOM   846  C CD   B ARG   A 1 85  ? 31.726 9.002   29.899 0.47 32.91 ? 65  ARG   A CD   1 
ATOM   847  N NE   A ARG   A 1 85  ? 33.119 7.711   29.876 0.53 20.05 ? 65  ARG   A NE   1 
ATOM   848  N NE   B ARG   A 1 85  ? 30.288 9.047   30.141 0.47 31.55 ? 65  ARG   A NE   1 
ATOM   849  C CZ   A ARG   A 1 85  ? 32.402 6.598   29.814 0.53 20.70 ? 65  ARG   A CZ   1 
ATOM   850  C CZ   B ARG   A 1 85  ? 29.483 7.997   30.063 0.47 15.76 ? 65  ARG   A CZ   1 
ATOM   851  N NH1  A ARG   A 1 85  ? 31.093 6.631   29.641 0.53 23.57 ? 65  ARG   A NH1  1 
ATOM   852  N NH1  B ARG   A 1 85  ? 29.955 6.776   29.866 0.47 19.05 ? 65  ARG   A NH1  1 
ATOM   853  N NH2  A ARG   A 1 85  ? 33.015 5.424   29.928 0.53 30.58 ? 65  ARG   A NH2  1 
ATOM   854  N NH2  B ARG   A 1 85  ? 28.174 8.175   30.176 0.47 24.24 ? 65  ARG   A NH2  1 
ATOM   855  H H    A ARG   A 1 85  ? 33.325 11.544  26.244 0.53 22.39 ? 65  ARG   A H    1 
ATOM   856  H H    B ARG   A 1 85  ? 33.345 11.490  26.276 0.47 22.37 ? 65  ARG   A H    1 
ATOM   857  H HA   A ARG   A 1 85  ? 30.794 10.568  26.276 0.53 20.35 ? 65  ARG   A HA   1 
ATOM   858  H HA   B ARG   A 1 85  ? 30.802 10.557  26.314 0.47 20.36 ? 65  ARG   A HA   1 
ATOM   859  H HB2  A ARG   A 1 85  ? 32.287 11.402  28.546 0.53 27.64 ? 65  ARG   A HB2  1 
ATOM   860  H HB2  B ARG   A 1 85  ? 32.400 11.375  28.506 0.47 27.65 ? 65  ARG   A HB2  1 
ATOM   861  H HB3  A ARG   A 1 85  ? 30.838 10.754  28.612 0.53 27.64 ? 65  ARG   A HB3  1 
ATOM   862  H HB3  B ARG   A 1 85  ? 30.859 11.018  28.660 0.47 27.65 ? 65  ARG   A HB3  1 
ATOM   863  H HG2  A ARG   A 1 85  ? 31.702 8.721   27.925 0.53 33.67 ? 65  ARG   A HG2  1 
ATOM   864  H HG2  B ARG   A 1 85  ? 31.527 8.789   27.867 0.47 31.61 ? 65  ARG   A HG2  1 
ATOM   865  H HG3  A ARG   A 1 85  ? 33.151 9.364   27.814 0.53 33.67 ? 65  ARG   A HG3  1 
ATOM   866  H HG3  B ARG   A 1 85  ? 32.989 9.239   28.298 0.47 31.61 ? 65  ARG   A HG3  1 
ATOM   867  H HD2  A ARG   A 1 85  ? 33.201 9.684   30.111 0.53 36.18 ? 65  ARG   A HD2  1 
ATOM   868  H HD2  B ARG   A 1 85  ? 32.042 8.103   30.081 0.47 39.51 ? 65  ARG   A HD2  1 
ATOM   869  H HD3  A ARG   A 1 85  ? 31.733 9.090   30.237 0.53 36.18 ? 65  ARG   A HD3  1 
ATOM   870  H HD3  B ARG   A 1 85  ? 32.159 9.632   30.495 0.47 39.51 ? 65  ARG   A HD3  1 
ATOM   871  H HE   A ARG   A 1 85  ? 33.967 7.637   30.004 0.53 24.07 ? 65  ARG   A HE   1 
ATOM   872  H HE   B ARG   A 1 85  ? 29.940 9.805   30.347 0.47 37.87 ? 65  ARG   A HE   1 
ATOM   873  H HH11 A ARG   A 1 85  ? 30.688 7.386   29.566 0.53 28.29 ? 65  ARG   A HH11 1 
ATOM   874  H HH11 B ARG   A 1 85  ? 30.802 6.651   29.785 0.47 22.88 ? 65  ARG   A HH11 1 
ATOM   875  H HH12 A ARG   A 1 85  ? 30.646 5.897   29.604 0.53 28.29 ? 65  ARG   A HH12 1 
ATOM   876  H HH12 B ARG   A 1 85  ? 29.415 6.109   29.818 0.47 22.88 ? 65  ARG   A HH12 1 
ATOM   877  H HH21 A ARG   A 1 85  ? 33.867 5.392   30.040 0.53 36.71 ? 65  ARG   A HH21 1 
ATOM   878  H HH21 B ARG   A 1 85  ? 27.856 8.964   30.298 0.47 29.10 ? 65  ARG   A HH21 1 
ATOM   879  H HH22 A ARG   A 1 85  ? 32.559 4.695   29.889 0.53 36.71 ? 65  ARG   A HH22 1 
ATOM   880  H HH22 B ARG   A 1 85  ? 27.642 7.500   30.127 0.47 29.10 ? 65  ARG   A HH22 1 
ATOM   881  N N    . GLY   A 1 86  ? 29.705 12.682  25.968 1.00 19.82 ? 66  GLY   A N    1 
ATOM   882  C CA   . GLY   A 1 86  ? 28.989 13.933  25.888 1.00 19.83 ? 66  GLY   A CA   1 
ATOM   883  C C    . GLY   A 1 86  ? 29.185 14.630  24.563 1.00 19.41 ? 66  GLY   A C    1 
ATOM   884  O O    . GLY   A 1 86  ? 30.233 14.531  23.920 1.00 19.16 ? 66  GLY   A O    1 
ATOM   885  H H    A GLY   A 1 86  ? 29.319 12.035  25.554 0.53 23.80 ? 66  GLY   A H    1 
ATOM   886  H H    B GLY   A 1 86  ? 29.301 12.027  25.585 0.47 23.80 ? 66  GLY   A H    1 
ATOM   887  H HA2  . GLY   A 1 86  ? 28.041 13.768  26.009 1.00 23.81 ? 66  GLY   A HA2  1 
ATOM   888  H HA3  . GLY   A 1 86  ? 29.299 14.525  26.592 1.00 23.81 ? 66  GLY   A HA3  1 
ATOM   889  N N    . ARG   A 1 87  ? 28.161 15.371  24.153 1.00 24.18 ? 67  ARG   A N    1 
ATOM   890  C CA   . ARG   A 1 87  ? 28.215 16.060  22.871 1.00 24.75 ? 67  ARG   A CA   1 
ATOM   891  C C    . ARG   A 1 87  ? 29.414 16.985  22.766 1.00 25.17 ? 67  ARG   A C    1 
ATOM   892  O O    . ARG   A 1 87  ? 30.044 17.082  21.705 1.00 24.25 ? 67  ARG   A O    1 
ATOM   893  C CB   . ARG   A 1 87  ? 26.944 16.865  22.677 1.00 34.35 ? 67  ARG   A CB   1 
ATOM   894  C CG   . ARG   A 1 87  ? 26.183 16.504  21.469 1.00 23.80 ? 67  ARG   A CG   1 
ATOM   895  C CD   . ARG   A 1 87  ? 24.987 17.377  21.446 1.00 24.45 ? 67  ARG   A CD   1 
ATOM   896  N NE   . ARG   A 1 87  ? 23.884 16.732  20.771 1.00 27.31 ? 67  ARG   A NE   1 
ATOM   897  C CZ   . ARG   A 1 87  ? 22.712 17.312  20.558 1.00 33.28 ? 67  ARG   A CZ   1 
ATOM   898  N NH1  . ARG   A 1 87  ? 22.468 18.550  20.959 1.00 39.90 ? 67  ARG   A NH1  1 
ATOM   899  N NH2  . ARG   A 1 87  ? 21.767 16.638  19.920 1.00 22.53 ? 67  ARG   A NH2  1 
ATOM   900  H H    . ARG   A 1 87  ? 27.432 15.490  24.593 1.00 29.03 ? 67  ARG   A H    1 
ATOM   901  H HA   . ARG   A 1 87  ? 28.288 15.390  22.172 1.00 29.71 ? 67  ARG   A HA   1 
ATOM   902  H HB2  . ARG   A 1 87  ? 26.366 16.723  23.442 1.00 41.24 ? 67  ARG   A HB2  1 
ATOM   903  H HB3  . ARG   A 1 87  ? 27.178 17.804  22.608 1.00 41.24 ? 67  ARG   A HB3  1 
ATOM   904  H HG2  . ARG   A 1 87  ? 26.715 16.660  20.673 1.00 28.58 ? 67  ARG   A HG2  1 
ATOM   905  H HG3  . ARG   A 1 87  ? 25.907 15.575  21.506 1.00 28.58 ? 67  ARG   A HG3  1 
ATOM   906  H HD2  . ARG   A 1 87  ? 24.716 17.576  22.356 1.00 29.36 ? 67  ARG   A HD2  1 
ATOM   907  H HD3  . ARG   A 1 87  ? 25.197 18.199  20.976 1.00 29.36 ? 67  ARG   A HD3  1 
ATOM   908  H HE   . ARG   A 1 87  ? 23.994 15.926  20.491 1.00 32.78 ? 67  ARG   A HE   1 
ATOM   909  H HH11 . ARG   A 1 87  ? 23.077 18.997  21.369 1.00 47.89 ? 67  ARG   A HH11 1 
ATOM   910  H HH12 . ARG   A 1 87  ? 21.700 18.907  20.810 1.00 47.89 ? 67  ARG   A HH12 1 
ATOM   911  H HH21 . ARG   A 1 87  ? 21.917 15.836  19.651 1.00 27.05 ? 67  ARG   A HH21 1 
ATOM   912  H HH22 . ARG   A 1 87  ? 21.002 17.004  19.776 1.00 27.05 ? 67  ARG   A HH22 1 
ATOM   913  N N    . GLU   A 1 88  ? 29.710 17.723  23.834 1.00 23.16 ? 68  GLU   A N    1 
ATOM   914  C CA   . GLU   A 1 88  ? 30.811 18.674  23.792 1.00 26.30 ? 68  GLU   A CA   1 
ATOM   915  C C    . GLU   A 1 88  ? 32.124 17.968  23.498 1.00 25.39 ? 68  GLU   A C    1 
ATOM   916  O O    . GLU   A 1 88  ? 32.886 18.385  22.618 1.00 24.80 ? 68  GLU   A O    1 
ATOM   917  C CB   . GLU   A 1 88  ? 30.889 19.439  25.118 1.00 28.26 ? 68  GLU   A CB   1 
ATOM   918  C CG   . GLU   A 1 88  ? 32.159 20.254  25.305 1.00 62.32 ? 68  GLU   A CG   1 
ATOM   919  C CD   . GLU   A 1 88  ? 32.144 21.052  26.600 1.00 76.24 ? 68  GLU   A CD   1 
ATOM   920  O OE1  . GLU   A 1 88  ? 31.040 21.347  27.105 1.00 58.07 ? 68  GLU   A OE1  1 
ATOM   921  O OE2  . GLU   A 1 88  ? 33.233 21.382  27.116 1.00 76.29 ? 68  GLU   A OE2  1 
ATOM   922  H H    A GLU   A 1 88  ? 29.293 17.691  24.586 0.68 27.81 ? 68  GLU   A H    1 
ATOM   923  H H    B GLU   A 1 88  ? 29.293 17.691  24.586 0.32 27.81 ? 68  GLU   A H    1 
ATOM   924  H HA   . GLU   A 1 88  ? 30.650 19.317  23.083 1.00 31.57 ? 68  GLU   A HA   1 
ATOM   925  H HB2  . GLU   A 1 88  ? 30.138 20.052  25.165 1.00 33.93 ? 68  GLU   A HB2  1 
ATOM   926  H HB3  . GLU   A 1 88  ? 30.841 18.800  25.846 1.00 33.93 ? 68  GLU   A HB3  1 
ATOM   927  H HG2  . GLU   A 1 88  ? 32.921 19.655  25.327 1.00 74.79 ? 68  GLU   A HG2  1 
ATOM   928  H HG3  . GLU   A 1 88  ? 32.249 20.878  24.567 1.00 74.79 ? 68  GLU   A HG3  1 
ATOM   929  N N    . LYS   A 1 89  ? 32.408 16.889  24.230 1.00 22.76 ? 69  LYS   A N    1 
ATOM   930  C CA   . LYS   A 1 89  ? 33.645 16.157  23.998 1.00 20.85 ? 69  LYS   A CA   1 
ATOM   931  C C    . LYS   A 1 89  ? 33.637 15.460  22.645 1.00 22.93 ? 69  LYS   A C    1 
ATOM   932  O O    . LYS   A 1 89  ? 34.692 15.332  22.014 1.00 20.16 ? 69  LYS   A O    1 
ATOM   933  C CB   . LYS   A 1 89  ? 33.878 15.161  25.125 1.00 21.36 ? 69  LYS   A CB   1 
ATOM   934  C CG   . LYS   A 1 89  ? 34.280 15.841  26.424 1.00 31.14 ? 69  LYS   A CG   1 
ATOM   935  C CD   . LYS   A 1 89  ? 35.022 14.897  27.346 1.00 37.69 ? 69  LYS   A CD   1 
ATOM   936  H H    . LYS   A 1 89  ? 31.909 16.569  24.853 1.00 27.32 ? 69  LYS   A H    1 
ATOM   937  H HA   . LYS   A 1 89  ? 34.388 16.780  24.001 1.00 25.03 ? 69  LYS   A HA   1 
ATOM   938  H HB2  . LYS   A 1 89  ? 33.060 14.664  25.284 1.00 25.65 ? 69  LYS   A HB2  1 
ATOM   939  H HB3  . LYS   A 1 89  ? 34.590 14.554  24.870 1.00 25.65 ? 69  LYS   A HB3  1 
ATOM   940  H HG2  . LYS   A 1 89  ? 34.861 16.592  26.226 1.00 37.38 ? 69  LYS   A HG2  1 
ATOM   941  H HG3  . LYS   A 1 89  ? 33.483 16.150  26.883 1.00 37.38 ? 69  LYS   A HG3  1 
ATOM   942  H HD2  . LYS   A 1 89  ? 34.451 14.140  27.548 1.00 45.24 ? 69  LYS   A HD2  1 
ATOM   943  H HD3  . LYS   A 1 89  ? 35.831 14.594  26.901 1.00 45.24 ? 69  LYS   A HD3  1 
ATOM   944  N N    . LEU   A 1 90  ? 32.468 15.023  22.173 1.00 18.27 ? 70  LEU   A N    1 
ATOM   945  C CA   . LEU   A 1 90  ? 32.398 14.447  20.828 1.00 14.70 ? 70  LEU   A CA   1 
ATOM   946  C C    . LEU   A 1 90  ? 32.733 15.486  19.769 1.00 17.58 ? 70  LEU   A C    1 
ATOM   947  O O    . LEU   A 1 90  ? 33.473 15.200  18.817 1.00 19.64 ? 70  LEU   A O    1 
ATOM   948  C CB   . LEU   A 1 90  ? 31.016 13.849  20.575 1.00 16.75 ? 70  LEU   A CB   1 
ATOM   949  C CG   . LEU   A 1 90  ? 30.755 12.520  21.297 1.00 18.01 ? 70  LEU   A CG   1 
ATOM   950  C CD1  . LEU   A 1 90  ? 29.270 12.223  21.377 1.00 20.10 ? 70  LEU   A CD1  1 
ATOM   951  C CD2  . LEU   A 1 90  ? 31.488 11.377  20.603 1.00 20.91 ? 70  LEU   A CD2  1 
ATOM   952  H H    . LEU   A 1 90  ? 31.721 15.048  22.598 1.00 21.94 ? 70  LEU   A H    1 
ATOM   953  H HA   . LEU   A 1 90  ? 33.047 13.729  20.766 1.00 17.66 ? 70  LEU   A HA   1 
ATOM   954  H HB2  . LEU   A 1 90  ? 30.346 14.483  20.874 1.00 20.12 ? 70  LEU   A HB2  1 
ATOM   955  H HB3  . LEU   A 1 90  ? 30.920 13.689  19.623 1.00 20.12 ? 70  LEU   A HB3  1 
ATOM   956  H HG   . LEU   A 1 90  ? 31.093 12.593  22.203 1.00 21.62 ? 70  LEU   A HG   1 
ATOM   957  H HD11 . LEU   A 1 90  ? 29.137 11.413  21.893 1.00 24.14 ? 70  LEU   A HD11 1 
ATOM   958  H HD12 . LEU   A 1 90  ? 28.822 12.967  21.809 1.00 24.14 ? 70  LEU   A HD12 1 
ATOM   959  H HD13 . LEU   A 1 90  ? 28.923 12.104  20.479 1.00 24.14 ? 70  LEU   A HD13 1 
ATOM   960  H HD21 . LEU   A 1 90  ? 31.224 10.538  21.013 1.00 25.10 ? 70  LEU   A HD21 1 
ATOM   961  H HD22 . LEU   A 1 90  ? 31.251 11.375  19.663 1.00 25.10 ? 70  LEU   A HD22 1 
ATOM   962  H HD23 . LEU   A 1 90  ? 32.444 11.508  20.703 1.00 25.10 ? 70  LEU   A HD23 1 
ATOM   963  N N    . GLY   A 1 91  ? 32.207 16.705  19.921 1.00 19.11 ? 71  GLY   A N    1 
ATOM   964  C CA   . GLY   A 1 91  ? 32.558 17.763  18.990 1.00 22.90 ? 71  GLY   A CA   1 
ATOM   965  C C    . GLY   A 1 91  ? 34.040 18.082  19.011 1.00 24.13 ? 71  GLY   A C    1 
ATOM   966  O O    . GLY   A 1 91  ? 34.655 18.320  17.966 1.00 24.02 ? 71  GLY   A O    1 
ATOM   967  H H    . GLY   A 1 91  ? 31.658 16.935  20.541 1.00 22.94 ? 71  GLY   A H    1 
ATOM   968  H HA2  . GLY   A 1 91  ? 32.315 17.493  18.091 1.00 27.49 ? 71  GLY   A HA2  1 
ATOM   969  H HA3  . GLY   A 1 91  ? 32.068 18.568  19.221 1.00 27.49 ? 71  GLY   A HA3  1 
ATOM   970  N N    . GLU   A 1 92  ? 34.638 18.094  20.200 1.00 26.28 ? 72  GLU   A N    1 
ATOM   971  C CA   . GLU   A 1 92  ? 36.077 18.308  20.295 1.00 25.62 ? 72  GLU   A CA   1 
ATOM   972  C C    . GLU   A 1 92  ? 36.838 17.153  19.677 1.00 26.94 ? 72  GLU   A C    1 
ATOM   973  O O    . GLU   A 1 92  ? 37.862 17.354  19.020 1.00 27.10 ? 72  GLU   A O    1 
ATOM   974  C CB   . GLU   A 1 92  ? 36.490 18.473  21.752 1.00 27.89 ? 72  GLU   A CB   1 
ATOM   975  C CG   . GLU   A 1 92  ? 35.937 19.717  22.356 1.00 33.95 ? 72  GLU   A CG   1 
ATOM   976  C CD   . GLU   A 1 92  ? 36.058 19.724  23.855 1.00 58.88 ? 72  GLU   A CD   1 
ATOM   977  O OE1  . GLU   A 1 92  ? 36.829 18.905  24.401 1.00 48.27 ? 72  GLU   A OE1  1 
ATOM   978  O OE2  . GLU   A 1 92  ? 35.374 20.548  24.489 1.00 56.20 ? 72  GLU   A OE2  1 
ATOM   979  H H    . GLU   A 1 92  ? 34.239 17.984  20.955 1.00 31.54 ? 72  GLU   A H    1 
ATOM   980  H HA   . GLU   A 1 92  ? 36.300 19.123  19.817 1.00 30.76 ? 72  GLU   A HA   1 
ATOM   981  H HB2  . GLU   A 1 92  ? 36.162 17.717  22.263 1.00 33.48 ? 72  GLU   A HB2  1 
ATOM   982  H HB3  . GLU   A 1 92  ? 37.458 18.515  21.806 1.00 33.48 ? 72  GLU   A HB3  1 
ATOM   983  H HG2  . GLU   A 1 92  ? 36.422 20.482  22.010 1.00 40.76 ? 72  GLU   A HG2  1 
ATOM   984  H HG3  . GLU   A 1 92  ? 34.997 19.790  22.128 1.00 40.76 ? 72  GLU   A HG3  1 
ATOM   985  N N    . HIS   A 1 93  ? 36.360 15.932  19.885 1.00 20.50 ? 73  HIS   A N    1 
ATOM   986  C CA   . HIS   A 1 93  ? 37.029 14.797  19.274 1.00 20.70 ? 73  HIS   A CA   1 
ATOM   987  C C    . HIS   A 1 93  ? 37.022 14.913  17.757 1.00 25.54 ? 73  HIS   A C    1 
ATOM   988  O O    . HIS   A 1 93  ? 37.979 14.498  17.097 1.00 22.49 ? 73  HIS   A O    1 
ATOM   989  C CB   . HIS   A 1 93  ? 36.368 13.491  19.679 1.00 21.56 ? 73  HIS   A CB   1 
ATOM   990  C CG   . HIS   A 1 93  ? 36.978 12.302  19.024 1.00 25.18 ? 73  HIS   A CG   1 
ATOM   991  N ND1  . HIS   A 1 93  ? 38.113 11.692  19.511 1.00 30.51 ? 73  HIS   A ND1  1 
ATOM   992  C CD2  . HIS   A 1 93  ? 36.644 11.638  17.892 1.00 28.80 ? 73  HIS   A CD2  1 
ATOM   993  C CE1  . HIS   A 1 93  ? 38.434 10.681  18.723 1.00 30.73 ? 73  HIS   A CE1  1 
ATOM   994  N NE2  . HIS   A 1 93  ? 37.559 10.628  17.733 1.00 33.15 ? 73  HIS   A NE2  1 
ATOM   995  H H    . HIS   A 1 93  ? 35.670 15.741  20.362 1.00 24.61 ? 73  HIS   A H    1 
ATOM   996  H HA   . HIS   A 1 93  ? 37.945 14.779  19.593 1.00 24.85 ? 73  HIS   A HA   1 
ATOM   997  H HB2  . HIS   A 1 93  ? 36.453 13.380  20.638 1.00 25.89 ? 73  HIS   A HB2  1 
ATOM   998  H HB3  . HIS   A 1 93  ? 35.431 13.522  19.430 1.00 25.89 ? 73  HIS   A HB3  1 
ATOM   999  H HD1  . HIS   A 1 93  ? 38.544 11.931  20.215 1.00 36.63 ? 73  HIS   A HD1  1 
ATOM   1000 H HD2  . HIS   A 1 93  ? 35.930 11.831  17.328 1.00 34.57 ? 73  HIS   A HD2  1 
ATOM   1001 H HE1  . HIS   A 1 93  ? 39.153 10.104  18.844 1.00 36.89 ? 73  HIS   A HE1  1 
ATOM   1002 N N    . ALA   A 1 94  ? 35.959 15.488  17.193 1.00 21.88 ? 74  ALA   A N    1 
ATOM   1003 C CA   . ALA   A 1 94  ? 35.832 15.563  15.741 1.00 20.17 ? 74  ALA   A CA   1 
ATOM   1004 C C    . ALA   A 1 94  ? 36.940 16.406  15.124 1.00 20.64 ? 74  ALA   A C    1 
ATOM   1005 O O    . ALA   A 1 94  ? 37.394 16.122  14.013 1.00 20.23 ? 74  ALA   A O    1 
ATOM   1006 C CB   . ALA   A 1 94  ? 34.463 16.131  15.373 1.00 20.02 ? 74  ALA   A CB   1 
ATOM   1007 H H    . ALA   A 1 94  ? 35.304 15.839  17.625 1.00 26.27 ? 74  ALA   A H    1 
ATOM   1008 H HA   . ALA   A 1 94  ? 35.900 14.669  15.371 1.00 24.21 ? 74  ALA   A HA   1 
ATOM   1009 H HB1  . ALA   A 1 94  ? 34.345 16.075  14.412 1.00 24.04 ? 74  ALA   A HB1  1 
ATOM   1010 H HB2  . ALA   A 1 94  ? 33.775 15.614  15.821 1.00 24.04 ? 74  ALA   A HB2  1 
ATOM   1011 H HB3  . ALA   A 1 94  ? 34.418 17.058  15.658 1.00 24.04 ? 74  ALA   A HB3  1 
ATOM   1012 N N    . VAL   A 1 95  ? 37.385 17.455  15.822 1.00 18.98 ? 75  VAL   A N    1 
ATOM   1013 C CA   . VAL   A 1 95  ? 38.486 18.269  15.321 1.00 26.77 ? 75  VAL   A CA   1 
ATOM   1014 C C    . VAL   A 1 95  ? 39.737 17.416  15.185 1.00 21.50 ? 75  VAL   A C    1 
ATOM   1015 O O    . VAL   A 1 95  ? 40.439 17.458  14.165 1.00 21.97 ? 75  VAL   A O    1 
ATOM   1016 C CB   . VAL   A 1 95  ? 38.724 19.473  16.253 1.00 25.19 ? 75  VAL   A CB   1 
ATOM   1017 C CG1  . VAL   A 1 95  ? 39.869 20.328  15.731 1.00 28.58 ? 75  VAL   A CG1  1 
ATOM   1018 C CG2  . VAL   A 1 95  ? 37.448 20.288  16.404 1.00 29.33 ? 75  VAL   A CG2  1 
ATOM   1019 H H    . VAL   A 1 95  ? 37.069 17.711  16.579 1.00 22.78 ? 75  VAL   A H    1 
ATOM   1020 H HA   . VAL   A 1 95  ? 38.253 18.611  14.443 1.00 32.14 ? 75  VAL   A HA   1 
ATOM   1021 H HB   . VAL   A 1 95  ? 38.973 19.153  17.134 1.00 30.24 ? 75  VAL   A HB   1 
ATOM   1022 H HG11 . VAL   A 1 95  ? 39.922 21.141  16.258 1.00 34.31 ? 75  VAL   A HG11 1 
ATOM   1023 H HG12 . VAL   A 1 95  ? 40.697 19.829  15.809 1.00 34.31 ? 75  VAL   A HG12 1 
ATOM   1024 H HG13 . VAL   A 1 95  ? 39.701 20.547  14.801 1.00 34.31 ? 75  VAL   A HG13 1 
ATOM   1025 H HG21 . VAL   A 1 95  ? 37.632 21.062  16.959 1.00 35.21 ? 75  VAL   A HG21 1 
ATOM   1026 H HG22 . VAL   A 1 95  ? 37.150 20.573  15.526 1.00 35.21 ? 75  VAL   A HG22 1 
ATOM   1027 H HG23 . VAL   A 1 95  ? 36.768 19.735  16.821 1.00 35.21 ? 75  VAL   A HG23 1 
ATOM   1028 N N    . TRP   A 1 96  ? 40.028 16.630  16.225 1.00 22.55 ? 76  TRP   A N    1 
ATOM   1029 C CA   . TRP   A 1 96  ? 41.166 15.721  16.198 1.00 19.61 ? 76  TRP   A CA   1 
ATOM   1030 C C    . TRP   A 1 96  ? 40.993 14.651  15.124 1.00 19.54 ? 76  TRP   A C    1 
ATOM   1031 O O    . TRP   A 1 96  ? 41.948 14.305  14.417 1.00 18.08 ? 76  TRP   A O    1 
ATOM   1032 C CB   . TRP   A 1 96  ? 41.326 15.077  17.574 1.00 21.64 ? 76  TRP   A CB   1 
ATOM   1033 C CG   . TRP   A 1 96  ? 42.407 14.081  17.610 1.00 22.21 ? 76  TRP   A CG   1 
ATOM   1034 C CD1  . TRP   A 1 96  ? 43.720 14.323  17.876 1.00 22.34 ? 76  TRP   A CD1  1 
ATOM   1035 C CD2  . TRP   A 1 96  ? 42.299 12.671  17.355 1.00 22.33 ? 76  TRP   A CD2  1 
ATOM   1036 N NE1  . TRP   A 1 96  ? 44.436 13.154  17.804 1.00 24.92 ? 76  TRP   A NE1  1 
ATOM   1037 C CE2  . TRP   A 1 96  ? 43.588 12.127  17.481 1.00 24.83 ? 76  TRP   A CE2  1 
ATOM   1038 C CE3  . TRP   A 1 96  ? 41.238 11.825  17.033 1.00 21.47 ? 76  TRP   A CE3  1 
ATOM   1039 C CZ2  . TRP   A 1 96  ? 43.847 10.771  17.306 1.00 23.33 ? 76  TRP   A CZ2  1 
ATOM   1040 C CZ3  . TRP   A 1 96  ? 41.493 10.473  16.850 1.00 25.70 ? 76  TRP   A CZ3  1 
ATOM   1041 C CH2  . TRP   A 1 96  ? 42.788 9.959   16.989 1.00 23.66 ? 76  TRP   A CH2  1 
ATOM   1042 H H    . TRP   A 1 96  ? 39.580 16.606  16.959 1.00 27.08 ? 76  TRP   A H    1 
ATOM   1043 H HA   . TRP   A 1 96  ? 41.972 16.220  15.992 1.00 23.54 ? 76  TRP   A HA   1 
ATOM   1044 H HB2  . TRP   A 1 96  ? 41.531 15.767  18.224 1.00 25.98 ? 76  TRP   A HB2  1 
ATOM   1045 H HB3  . TRP   A 1 96  ? 40.498 14.631  17.813 1.00 25.98 ? 76  TRP   A HB3  1 
ATOM   1046 H HD1  . TRP   A 1 96  ? 44.079 15.157  18.078 1.00 26.83 ? 76  TRP   A HD1  1 
ATOM   1047 H HE1  . TRP   A 1 96  ? 45.282 13.079  17.939 1.00 29.92 ? 76  TRP   A HE1  1 
ATOM   1048 H HE3  . TRP   A 1 96  ? 40.376 12.161  16.942 1.00 25.77 ? 76  TRP   A HE3  1 
ATOM   1049 H HZ2  . TRP   A 1 96  ? 44.706 10.428  17.401 1.00 28.00 ? 76  TRP   A HZ2  1 
ATOM   1050 H HZ3  . TRP   A 1 96  ? 40.793 9.900   16.632 1.00 30.85 ? 76  TRP   A HZ3  1 
ATOM   1051 H HH2  . TRP   A 1 96  ? 42.934 9.049   16.864 1.00 28.41 ? 76  TRP   A HH2  1 
ATOM   1052 N N    . SER   A 1 97  ? 39.783 14.104  15.003 1.00 18.78 ? 77  SER   A N    1 
ATOM   1053 C CA   . SER   A 1 97  ? 39.531 13.061  14.016 1.00 17.63 ? 77  SER   A CA   1 
ATOM   1054 C C    . SER   A 1 97  ? 39.772 13.570  12.601 1.00 19.46 ? 77  SER   A C    1 
ATOM   1055 O O    . SER   A 1 97  ? 40.403 12.893  11.785 1.00 15.94 ? 77  SER   A O    1 
ATOM   1056 C CB   . SER   A 1 97  ? 38.092 12.563  14.176 1.00 19.04 ? 77  SER   A CB   1 
ATOM   1057 O OG   . SER   A 1 97  ? 37.727 11.655  13.153 1.00 21.32 ? 77  SER   A OG   1 
ATOM   1058 H H    . SER   A 1 97  ? 39.098 14.318  15.477 1.00 22.55 ? 77  SER   A H    1 
ATOM   1059 H HA   . SER   A 1 97  ? 40.135 12.317  14.166 1.00 21.17 ? 77  SER   A HA   1 
ATOM   1060 H HB2  . SER   A 1 97  ? 38.011 12.116  15.033 1.00 22.86 ? 77  SER   A HB2  1 
ATOM   1061 H HB3  . SER   A 1 97  ? 37.493 13.326  14.143 1.00 22.86 ? 77  SER   A HB3  1 
ATOM   1062 H HG   . SER   A 1 97  ? 38.201 10.963  13.200 1.00 25.59 ? 77  SER   A HG   1 
ATOM   1063 N N    . LEU   A 1 98  ? 39.275 14.765  12.290 1.00 16.46 ? 78  LEU   A N    1 
ATOM   1064 C CA   . LEU   A 1 98  ? 39.490 15.339  10.970 1.00 18.64 ? 78  LEU   A CA   1 
ATOM   1065 C C    . LEU   A 1 98  ? 40.953 15.693  10.755 1.00 20.07 ? 78  LEU   A C    1 
ATOM   1066 O O    . LEU   A 1 98  ? 41.436 15.658  9.620  1.00 22.13 ? 78  LEU   A O    1 
ATOM   1067 C CB   . LEU   A 1 98  ? 38.590 16.559  10.803 1.00 21.72 ? 78  LEU   A CB   1 
ATOM   1068 C CG   . LEU   A 1 98  ? 38.305 17.118  9.414  1.00 32.71 ? 78  LEU   A CG   1 
ATOM   1069 C CD1  . LEU   A 1 98  ? 37.797 16.085  8.444  1.00 22.76 ? 78  LEU   A CD1  1 
ATOM   1070 C CD2  . LEU   A 1 98  ? 37.286 18.259  9.581  1.00 31.00 ? 78  LEU   A CD2  1 
ATOM   1071 H H    . LEU   A 1 98  ? 38.813 15.258  12.822 1.00 19.77 ? 78  LEU   A H    1 
ATOM   1072 H HA   . LEU   A 1 98  ? 39.247 14.697  10.285 1.00 22.38 ? 78  LEU   A HA   1 
ATOM   1073 H HB2  . LEU   A 1 98  ? 37.727 16.333  11.184 1.00 26.08 ? 78  LEU   A HB2  1 
ATOM   1074 H HB3  . LEU   A 1 98  ? 38.995 17.283  11.307 1.00 26.08 ? 78  LEU   A HB3  1 
ATOM   1075 H HG   . LEU   A 1 98  ? 39.132 17.440  9.022  1.00 39.27 ? 78  LEU   A HG   1 
ATOM   1076 H HD11 . LEU   A 1 98  ? 37.602 16.516  7.597  1.00 27.32 ? 78  LEU   A HD11 1 
ATOM   1077 H HD12 . LEU   A 1 98  ? 38.477 15.406  8.320  1.00 27.32 ? 78  LEU   A HD12 1 
ATOM   1078 H HD13 . LEU   A 1 98  ? 36.990 15.684  8.804  1.00 27.32 ? 78  LEU   A HD13 1 
ATOM   1079 H HD21 . LEU   A 1 98  ? 36.968 18.528  8.705  1.00 37.21 ? 78  LEU   A HD21 1 
ATOM   1080 H HD22 . LEU   A 1 98  ? 36.544 17.942  10.119 1.00 37.21 ? 78  LEU   A HD22 1 
ATOM   1081 H HD23 . LEU   A 1 98  ? 37.718 19.007  10.020 1.00 37.21 ? 78  LEU   A HD23 1 
ATOM   1082 N N    . GLN   A 1 99  ? 41.683 16.024  11.824 1.00 17.81 ? 79  GLN   A N    1 
ATOM   1083 C CA   . GLN   A 1 99  ? 43.112 16.269  11.676 1.00 17.98 ? 79  GLN   A CA   1 
ATOM   1084 C C    . GLN   A 1 99  ? 43.856 14.981  11.332 1.00 18.46 ? 79  GLN   A C    1 
ATOM   1085 O O    . GLN   A 1 99  ? 44.706 14.960  10.433 1.00 20.99 ? 79  GLN   A O    1 
ATOM   1086 C CB   . GLN   A 1 99  ? 43.680 16.888  12.955 1.00 20.50 ? 79  GLN   A CB   1 
ATOM   1087 C CG   . GLN   A 1 99  ? 45.205 16.959  12.979 1.00 30.67 ? 79  GLN   A CG   1 
ATOM   1088 C CD   . GLN   A 1 99  ? 45.770 17.312  14.348 1.00 38.93 ? 79  GLN   A CD   1 
ATOM   1089 O OE1  . GLN   A 1 99  ? 46.775 16.742  14.779 1.00 33.35 ? 79  GLN   A OE1  1 
ATOM   1090 N NE2  . GLN   A 1 99  ? 45.135 18.255  15.030 1.00 41.26 ? 79  GLN   A NE2  1 
ATOM   1091 H H    . GLN   A 1 99  ? 41.380 16.110  12.624 1.00 21.39 ? 79  GLN   A H    1 
ATOM   1092 H HA   . GLN   A 1 99  ? 43.244 16.901  10.951 1.00 21.58 ? 79  GLN   A HA   1 
ATOM   1093 H HB2  . GLN   A 1 99  ? 43.340 17.793  13.041 1.00 24.61 ? 79  GLN   A HB2  1 
ATOM   1094 H HB3  . GLN   A 1 99  ? 43.396 16.354  13.713 1.00 24.61 ? 79  GLN   A HB3  1 
ATOM   1095 H HG2  . GLN   A 1 99  ? 45.563 16.094  12.723 1.00 36.82 ? 79  GLN   A HG2  1 
ATOM   1096 H HG3  . GLN   A 1 99  ? 45.498 17.638  12.352 1.00 36.82 ? 79  GLN   A HG3  1 
ATOM   1097 H HE21 . GLN   A 1 99  ? 44.440 18.634  14.695 1.00 49.52 ? 79  GLN   A HE21 1 
ATOM   1098 H HE22 . GLN   A 1 99  ? 45.419 18.487  15.808 1.00 49.52 ? 79  GLN   A HE22 1 
ATOM   1099 N N    . CYS   A 1 100 ? 43.554 13.893  12.046 1.00 17.47 ? 80  CYS   A N    1 
ATOM   1100 C CA   . CYS   A 1 100 ? 44.363 12.685  11.966 1.00 16.82 ? 80  CYS   A CA   1 
ATOM   1101 C C    . CYS   A 1 100 ? 43.879 11.698  10.919 1.00 15.13 ? 80  CYS   A C    1 
ATOM   1102 O O    . CYS   A 1 100 ? 44.638 10.810  10.534 1.00 15.84 ? 80  CYS   A O    1 
ATOM   1103 C CB   . CYS   A 1 100 ? 44.403 11.997  13.326 1.00 16.28 ? 80  CYS   A CB   1 
ATOM   1104 S SG   . CYS   A 1 100 ? 45.234 13.013  14.550 1.00 18.80 ? 80  CYS   A SG   1 
ATOM   1105 H H    . CYS   A 1 100 ? 42.885 13.834  12.582 1.00 20.98 ? 80  CYS   A H    1 
ATOM   1106 H HA   . CYS   A 1 100 ? 45.268 12.938  11.726 1.00 20.20 ? 80  CYS   A HA   1 
ATOM   1107 H HB2  . CYS   A 1 100 ? 43.496 11.832  13.629 1.00 19.55 ? 80  CYS   A HB2  1 
ATOM   1108 H HB3  . CYS   A 1 100 ? 44.883 11.158  13.247 1.00 19.55 ? 80  CYS   A HB3  1 
ATOM   1109 H HG   . CYS   A 1 100 ? 45.499 12.335  15.505 1.00 22.58 ? 80  CYS   A HG   1 
ATOM   1110 N N    . PHE   A 1 101 ? 42.641 11.829  10.469 1.00 15.76 ? 81  PHE   A N    1 
ATOM   1111 C CA   . PHE   A 1 101 ? 42.075 10.988  9.417  1.00 17.00 ? 81  PHE   A CA   1 
ATOM   1112 C C    . PHE   A 1 101 ? 41.415 11.940  8.431  1.00 16.00 ? 81  PHE   A C    1 
ATOM   1113 O O    . PHE   A 1 101 ? 40.182 12.035  8.349  1.00 17.04 ? 81  PHE   A O    1 
ATOM   1114 C CB   . PHE   A 1 101 ? 41.075 9.986   9.982  1.00 15.19 ? 81  PHE   A CB   1 
ATOM   1115 C CG   . PHE   A 1 101 ? 41.618 9.116   11.069 1.00 12.65 ? 81  PHE   A CG   1 
ATOM   1116 C CD1  . PHE   A 1 101 ? 42.352 7.982   10.777 1.00 12.35 ? 81  PHE   A CD1  1 
ATOM   1117 C CD2  . PHE   A 1 101 ? 41.348 9.414   12.393 1.00 15.96 ? 81  PHE   A CD2  1 
ATOM   1118 C CE1  . PHE   A 1 101 ? 42.819 7.170   11.786 1.00 15.02 ? 81  PHE   A CE1  1 
ATOM   1119 C CE2  . PHE   A 1 101 ? 41.815 8.605   13.400 1.00 16.06 ? 81  PHE   A CE2  1 
ATOM   1120 C CZ   . PHE   A 1 101 ? 42.553 7.486   13.104 1.00 15.23 ? 81  PHE   A CZ   1 
ATOM   1121 H H    . PHE   A 1 101 ? 42.088 12.416  10.766 1.00 18.93 ? 81  PHE   A H    1 
ATOM   1122 H HA   . PHE   A 1 101 ? 42.767 10.473  8.974  1.00 20.41 ? 81  PHE   A HA   1 
ATOM   1123 H HB2  . PHE   A 1 101 ? 40.320 10.474  10.346 1.00 18.25 ? 81  PHE   A HB2  1 
ATOM   1124 H HB3  . PHE   A 1 101 ? 40.779 9.406   9.263  1.00 18.25 ? 81  PHE   A HB3  1 
ATOM   1125 H HD1  . PHE   A 1 101 ? 42.533 7.765   9.891  1.00 14.83 ? 81  PHE   A HD1  1 
ATOM   1126 H HD2  . PHE   A 1 101 ? 40.847 10.169  12.603 1.00 19.16 ? 81  PHE   A HD2  1 
ATOM   1127 H HE1  . PHE   A 1 101 ? 43.312 6.409   11.580 1.00 18.04 ? 81  PHE   A HE1  1 
ATOM   1128 H HE2  . PHE   A 1 101 ? 41.630 8.816   14.287 1.00 19.28 ? 81  PHE   A HE2  1 
ATOM   1129 H HZ   . PHE   A 1 101 ? 42.873 6.943   13.788 1.00 18.29 ? 81  PHE   A HZ   1 
ATOM   1130 N N    . PRO   A 1 102 ? 42.223 12.704  7.691  1.00 15.09 ? 82  PRO   A N    1 
ATOM   1131 C CA   . PRO   A 1 102 ? 41.685 13.890  7.004  1.00 18.09 ? 82  PRO   A CA   1 
ATOM   1132 C C    . PRO   A 1 102 ? 40.724 13.585  5.866  1.00 18.75 ? 82  PRO   A C    1 
ATOM   1133 O O    . PRO   A 1 102 ? 39.921 14.458  5.518  1.00 21.75 ? 82  PRO   A O    1 
ATOM   1134 C CB   . PRO   A 1 102 ? 42.951 14.597  6.497  1.00 18.95 ? 82  PRO   A CB   1 
ATOM   1135 C CG   . PRO   A 1 102 ? 44.013 13.516  6.453  1.00 19.58 ? 82  PRO   A CG   1 
ATOM   1136 C CD   . PRO   A 1 102 ? 43.690 12.619  7.616  1.00 16.84 ? 82  PRO   A CD   1 
ATOM   1137 H HA   . PRO   A 1 102 ? 41.227 14.457  7.644  1.00 21.72 ? 82  PRO   A HA   1 
ATOM   1138 H HB2  . PRO   A 1 102 ? 42.792 14.964  5.613  1.00 22.75 ? 82  PRO   A HB2  1 
ATOM   1139 H HB3  . PRO   A 1 102 ? 43.201 15.305  7.110  1.00 22.75 ? 82  PRO   A HB3  1 
ATOM   1140 H HG2  . PRO   A 1 102 ? 43.959 13.031  5.614  1.00 23.51 ? 82  PRO   A HG2  1 
ATOM   1141 H HG3  . PRO   A 1 102 ? 44.893 13.911  6.552  1.00 23.51 ? 82  PRO   A HG3  1 
ATOM   1142 H HD2  . PRO   A 1 102 ? 43.977 11.708  7.442  1.00 20.22 ? 82  PRO   A HD2  1 
ATOM   1143 H HD3  . PRO   A 1 102 ? 44.100 12.946  8.432  1.00 20.22 ? 82  PRO   A HD3  1 
ATOM   1144 N N    . ASP   A 1 103 ? 40.770 12.400  5.273  1.00 17.07 ? 83  ASP   A N    1 
ATOM   1145 C CA   . ASP   A 1 103 ? 39.961 12.101  4.098  1.00 17.84 ? 83  ASP   A CA   1 
ATOM   1146 C C    . ASP   A 1 103 ? 39.171 10.815  4.303  1.00 17.87 ? 83  ASP   A C    1 
ATOM   1147 O O    . ASP   A 1 103 ? 38.777 10.150  3.345  1.00 16.27 ? 83  ASP   A O    1 
ATOM   1148 C CB   . ASP   A 1 103 ? 40.833 12.004  2.847  1.00 20.98 ? 83  ASP   A CB   1 
ATOM   1149 C CG   . ASP   A 1 103 ? 41.910 10.941  2.946  1.00 24.52 ? 83  ASP   A CG   1 
ATOM   1150 O OD1  . ASP   A 1 103 ? 41.978 10.205  3.953  1.00 18.35 ? 83  ASP   A OD1  1 
ATOM   1151 O OD2  . ASP   A 1 103 ? 42.715 10.836  1.993  1.00 26.13 ? 83  ASP   A OD2  1 
ATOM   1152 H H    . ASP   A 1 103 ? 41.265 11.747  5.534  1.00 20.50 ? 83  ASP   A H    1 
ATOM   1153 H HA   . ASP   A 1 103 ? 39.327 12.822  3.960  1.00 21.42 ? 83  ASP   A HA   1 
ATOM   1154 H HB2  . ASP   A 1 103 ? 40.270 11.787  2.088  1.00 25.19 ? 83  ASP   A HB2  1 
ATOM   1155 H HB3  . ASP   A 1 103 ? 41.270 12.858  2.702  1.00 25.19 ? 83  ASP   A HB3  1 
ATOM   1156 N N    . TRP   A 1 104 ? 38.907 10.479  5.558  1.00 14.86 ? 84  TRP   A N    1 
ATOM   1157 C CA   . TRP   A 1 104 ? 38.320 9.194   5.902  1.00 15.96 ? 84  TRP   A CA   1 
ATOM   1158 C C    . TRP   A 1 104 ? 36.976 8.976   5.226  1.00 13.68 ? 84  TRP   A C    1 
ATOM   1159 O O    . TRP   A 1 104 ? 36.104 9.846   5.244  1.00 15.08 ? 84  TRP   A O    1 
ATOM   1160 C CB   . TRP   A 1 104 ? 38.126 9.118   7.414  1.00 15.16 ? 84  TRP   A CB   1 
ATOM   1161 C CG   . TRP   A 1 104 ? 37.773 7.766   7.869  1.00 12.73 ? 84  TRP   A CG   1 
ATOM   1162 C CD1  . TRP   A 1 104 ? 36.548 7.311   8.238  1.00 12.85 ? 84  TRP   A CD1  1 
ATOM   1163 C CD2  . TRP   A 1 104 ? 38.673 6.669   7.984  1.00 11.84 ? 84  TRP   A CD2  1 
ATOM   1164 N NE1  . TRP   A 1 104 ? 36.638 5.995   8.604  1.00 13.87 ? 84  TRP   A NE1  1 
ATOM   1165 C CE2  . TRP   A 1 104 ? 37.932 5.572   8.449  1.00 12.99 ? 84  TRP   A CE2  1 
ATOM   1166 C CE3  . TRP   A 1 104 ? 40.040 6.513   7.756  1.00 12.80 ? 84  TRP   A CE3  1 
ATOM   1167 C CZ2  . TRP   A 1 104 ? 38.509 4.334   8.691  1.00 13.94 ? 84  TRP   A CZ2  1 
ATOM   1168 C CZ3  . TRP   A 1 104 ? 40.613 5.289   7.982  1.00 12.47 ? 84  TRP   A CZ3  1 
ATOM   1169 C CH2  . TRP   A 1 104 ? 39.847 4.208   8.448  1.00 13.20 ? 84  TRP   A CH2  1 
ATOM   1170 H H    . TRP   A 1 104 ? 39.060 10.983  6.238  1.00 17.85 ? 84  TRP   A H    1 
ATOM   1171 H HA   . TRP   A 1 104 ? 38.920 8.494   5.601  1.00 19.16 ? 84  TRP   A HA   1 
ATOM   1172 H HB2  . TRP   A 1 104 ? 38.952 9.378   7.852  1.00 18.20 ? 84  TRP   A HB2  1 
ATOM   1173 H HB3  . TRP   A 1 104 ? 37.410 9.720   7.672  1.00 18.20 ? 84  TRP   A HB3  1 
ATOM   1174 H HD1  . TRP   A 1 104 ? 35.768 7.816   8.242  1.00 15.44 ? 84  TRP   A HD1  1 
ATOM   1175 H HE1  . TRP   A 1 104 ? 35.986 5.510   8.887  1.00 16.65 ? 84  TRP   A HE1  1 
ATOM   1176 H HE3  . TRP   A 1 104 ? 40.554 7.228   7.457  1.00 15.37 ? 84  TRP   A HE3  1 
ATOM   1177 H HZ2  . TRP   A 1 104 ? 38.005 3.619   9.005  1.00 16.74 ? 84  TRP   A HZ2  1 
ATOM   1178 H HZ3  . TRP   A 1 104 ? 41.522 5.172   7.824  1.00 14.98 ? 84  TRP   A HZ3  1 
ATOM   1179 H HH2  . TRP   A 1 104 ? 40.260 3.388   8.594  1.00 15.86 ? 84  TRP   A HH2  1 
ATOM   1180 N N    . VAL   A 1 105 ? 36.779 7.774   4.697  1.00 14.38 ? 85  VAL   A N    1 
ATOM   1181 C CA   . VAL   A 1 105 ? 35.489 7.369   4.161  1.00 15.69 ? 85  VAL   A CA   1 
ATOM   1182 C C    . VAL   A 1 105 ? 35.151 5.974   4.670  1.00 14.02 ? 85  VAL   A C    1 
ATOM   1183 O O    . VAL   A 1 105 ? 36.031 5.109   4.806  1.00 16.14 ? 85  VAL   A O    1 
ATOM   1184 C CB   . VAL   A 1 105 ? 35.460 7.381   2.615  1.00 16.59 ? 85  VAL   A CB   1 
ATOM   1185 C CG1  . VAL   A 1 105 ? 35.719 8.779   2.099  1.00 19.52 ? 85  VAL   A CG1  1 
ATOM   1186 C CG2  . VAL   A 1 105 ? 36.456 6.386   2.052  1.00 20.56 ? 85  VAL   A CG2  1 
ATOM   1187 H H    . VAL   A 1 105 ? 37.387 7.169   4.637  1.00 17.27 ? 85  VAL   A H    1 
ATOM   1188 H HA   . VAL   A 1 105 ? 34.820 7.992   4.487  1.00 18.84 ? 85  VAL   A HA   1 
ATOM   1189 H HB   . VAL   A 1 105 ? 34.580 7.111   2.310  1.00 19.92 ? 85  VAL   A HB   1 
ATOM   1190 H HG11 . VAL   A 1 105 ? 35.559 8.797   1.143  1.00 23.43 ? 85  VAL   A HG11 1 
ATOM   1191 H HG12 . VAL   A 1 105 ? 35.120 9.397   2.547  1.00 23.43 ? 85  VAL   A HG12 1 
ATOM   1192 H HG13 . VAL   A 1 105 ? 36.641 9.018   2.285  1.00 23.43 ? 85  VAL   A HG13 1 
ATOM   1193 H HG21 . VAL   A 1 105 ? 36.468 6.464   1.085  1.00 24.68 ? 85  VAL   A HG21 1 
ATOM   1194 H HG22 . VAL   A 1 105 ? 37.336 6.582   2.410  1.00 24.68 ? 85  VAL   A HG22 1 
ATOM   1195 H HG23 . VAL   A 1 105 ? 36.187 5.490   2.308  1.00 24.68 ? 85  VAL   A HG23 1 
ATOM   1196 N N    . TRP   A 1 106 ? 33.867 5.763   4.940  1.00 15.60 ? 86  TRP   A N    1 
ATOM   1197 C CA   . TRP   A 1 106 ? 33.315 4.443   5.196  1.00 13.02 ? 86  TRP   A CA   1 
ATOM   1198 C C    . TRP   A 1 106 ? 32.780 3.901   3.878  1.00 15.60 ? 86  TRP   A C    1 
ATOM   1199 O O    . TRP   A 1 106 ? 32.090 4.618   3.149  1.00 19.44 ? 86  TRP   A O    1 
ATOM   1200 C CB   . TRP   A 1 106 ? 32.192 4.504   6.227  1.00 16.56 ? 86  TRP   A CB   1 
ATOM   1201 C CG   . TRP   A 1 106 ? 32.525 5.202   7.511  1.00 13.55 ? 86  TRP   A CG   1 
ATOM   1202 C CD1  . TRP   A 1 106 ? 32.061 6.411   7.918  1.00 14.74 ? 86  TRP   A CD1  1 
ATOM   1203 C CD2  . TRP   A 1 106 ? 33.355 4.711   8.576  1.00 12.53 ? 86  TRP   A CD2  1 
ATOM   1204 N NE1  . TRP   A 1 106 ? 32.551 6.715   9.163  1.00 14.67 ? 86  TRP   A NE1  1 
ATOM   1205 C CE2  . TRP   A 1 106 ? 33.352 5.690   9.590  1.00 12.91 ? 86  TRP   A CE2  1 
ATOM   1206 C CE3  . TRP   A 1 106 ? 34.108 3.549   8.765  1.00 13.63 ? 86  TRP   A CE3  1 
ATOM   1207 C CZ2  . TRP   A 1 106 ? 34.067 5.540   10.773 1.00 14.08 ? 86  TRP   A CZ2  1 
ATOM   1208 C CZ3  . TRP   A 1 106 ? 34.819 3.405   9.938  1.00 13.15 ? 86  TRP   A CZ3  1 
ATOM   1209 C CH2  . TRP   A 1 106 ? 34.791 4.394   10.932 1.00 13.01 ? 86  TRP   A CH2  1 
ATOM   1210 H H    . TRP   A 1 106 ? 33.280 6.389   4.981  1.00 18.74 ? 86  TRP   A H    1 
ATOM   1211 H HA   . TRP   A 1 106 ? 34.002 3.853   5.543  1.00 15.64 ? 86  TRP   A HA   1 
ATOM   1212 H HB2  . TRP   A 1 106 ? 31.441 4.972   5.831  1.00 19.88 ? 86  TRP   A HB2  1 
ATOM   1213 H HB3  . TRP   A 1 106 ? 31.936 3.595   6.451  1.00 19.88 ? 86  TRP   A HB3  1 
ATOM   1214 H HD1  . TRP   A 1 106 ? 31.491 6.956   7.424  1.00 17.70 ? 86  TRP   A HD1  1 
ATOM   1215 H HE1  . TRP   A 1 106 ? 32.383 7.434   9.604  1.00 17.62 ? 86  TRP   A HE1  1 
ATOM   1216 H HE3  . TRP   A 1 106 ? 34.128 2.886   8.113  1.00 16.37 ? 86  TRP   A HE3  1 
ATOM   1217 H HZ2  . TRP   A 1 106 ? 34.053 6.197   11.431 1.00 16.91 ? 86  TRP   A HZ2  1 
ATOM   1218 H HZ3  . TRP   A 1 106 ? 35.327 2.638   10.072 1.00 15.79 ? 86  TRP   A HZ3  1 
ATOM   1219 H HH2  . TRP   A 1 106 ? 35.276 4.266   11.716 1.00 15.63 ? 86  TRP   A HH2  1 
ATOM   1220 N N    . THR   A 1 107 ? 33.120 2.659   3.576  1.00 16.66 ? 87  THR   A N    1 
ATOM   1221 C CA   . THR   A 1 107 ? 32.776 2.003   2.322  1.00 22.00 ? 87  THR   A CA   1 
ATOM   1222 C C    . THR   A 1 107 ? 32.092 0.678   2.632  1.00 17.00 ? 87  THR   A C    1 
ATOM   1223 O O    . THR   A 1 107 ? 32.167 0.165   3.749  1.00 15.54 ? 87  THR   A O    1 
ATOM   1224 C CB   . THR   A 1 107 ? 34.040 1.756   1.462  1.00 15.45 ? 87  THR   A CB   1 
ATOM   1225 O OG1  . THR   A 1 107 ? 34.731 0.620   1.967  1.00 25.72 ? 87  THR   A OG1  1 
ATOM   1226 C CG2  . THR   A 1 107 ? 34.964 2.958   1.509  1.00 34.07 ? 87  THR   A CG2  1 
ATOM   1227 H H    . THR   A 1 107 ? 33.571 2.151   4.104  1.00 20.01 ? 87  THR   A H    1 
ATOM   1228 H HA   . THR   A 1 107 ? 32.162 2.560   1.818  1.00 26.41 ? 87  THR   A HA   1 
ATOM   1229 H HB   . THR   A 1 107 ? 33.781 1.606   0.539  1.00 18.55 ? 87  THR   A HB   1 
ATOM   1230 H HG1  . THR   A 1 107 ? 35.121 0.817   2.685  1.00 30.87 ? 87  THR   A HG1  1 
ATOM   1231 H HG21 . THR   A 1 107 ? 35.797 2.753   1.056  1.00 40.89 ? 87  THR   A HG21 1 
ATOM   1232 H HG22 . THR   A 1 107 ? 34.546 3.715   1.070  1.00 40.89 ? 87  THR   A HG22 1 
ATOM   1233 H HG23 . THR   A 1 107 ? 35.156 3.194   2.430  1.00 40.89 ? 87  THR   A HG23 1 
ATOM   1234 N N    . ASP   A 1 108 ? 31.424 0.107   1.631  1.00 17.81 ? 88  ASP   A N    1 
ATOM   1235 C CA   . ASP   A 1 108 ? 30.834 -1.225  1.749  1.00 15.63 ? 88  ASP   A CA   1 
ATOM   1236 C C    . ASP   A 1 108 ? 29.943 -1.318  2.990  1.00 14.15 ? 88  ASP   A C    1 
ATOM   1237 O O    . ASP   A 1 108 ? 30.007 -2.278  3.768  1.00 17.09 ? 88  ASP   A O    1 
ATOM   1238 C CB   . ASP   A 1 108 ? 31.924 -2.294  1.777  1.00 18.61 ? 88  ASP   A CB   1 
ATOM   1239 C CG   . ASP   A 1 108 ? 31.390 -3.678  1.462  1.00 45.75 ? 88  ASP   A CG   1 
ATOM   1240 O OD1  . ASP   A 1 108 ? 30.216 -3.787  1.051  1.00 40.96 ? 88  ASP   A OD1  1 
ATOM   1241 O OD2  . ASP   A 1 108 ? 32.147 -4.658  1.622  1.00 54.54 ? 88  ASP   A OD2  1 
ATOM   1242 H H    . ASP   A 1 108 ? 31.298 0.475   0.864  1.00 21.38 ? 88  ASP   A H    1 
ATOM   1243 H HA   . ASP   A 1 108 ? 30.272 -1.385  0.975  1.00 18.77 ? 88  ASP   A HA   1 
ATOM   1244 H HB2  . ASP   A 1 108 ? 32.599 -2.075  1.116  1.00 22.34 ? 88  ASP   A HB2  1 
ATOM   1245 H HB3  . ASP   A 1 108 ? 32.321 -2.319  2.662  1.00 22.34 ? 88  ASP   A HB3  1 
ATOM   1246 N N    . ILE   A 1 109 ? 29.101 -0.308  3.153  1.00 13.21 ? 89  ILE   A N    1 
ATOM   1247 C CA   . ILE   A 1 109 ? 28.289 -0.147  4.357  1.00 14.47 ? 89  ILE   A CA   1 
ATOM   1248 C C    . ILE   A 1 109 ? 27.102 -1.097  4.297  1.00 16.67 ? 89  ILE   A C    1 
ATOM   1249 O O    . ILE   A 1 109 ? 26.302 -1.062  3.356  1.00 18.41 ? 89  ILE   A O    1 
ATOM   1250 C CB   . ILE   A 1 109 ? 27.819 1.303   4.498  1.00 16.51 ? 89  ILE   A CB   1 
ATOM   1251 C CG1  . ILE   A 1 109 ? 29.013 2.229   4.727  1.00 16.47 ? 89  ILE   A CG1  1 
ATOM   1252 C CG2  . ILE   A 1 109 ? 26.813 1.425   5.635  1.00 17.95 ? 89  ILE   A CG2  1 
ATOM   1253 C CD1  . ILE   A 1 109 ? 28.767 3.634   4.249  1.00 16.59 ? 89  ILE   A CD1  1 
ATOM   1254 N N    . GLN   A 1 110 ? 26.969 -1.933  5.318  1.00 13.41 ? 90  GLN   A N    1 
ATOM   1255 C CA   . GLN   A 1 110 ? 25.813 -2.804  5.480  1.00 14.49 ? 90  GLN   A CA   1 
ATOM   1256 C C    . GLN   A 1 110 ? 25.173 -2.482  6.821  1.00 14.65 ? 90  GLN   A C    1 
ATOM   1257 O O    . GLN   A 1 110 ? 25.782 -2.709  7.872  1.00 13.37 ? 90  GLN   A O    1 
ATOM   1258 C CB   . GLN   A 1 110 ? 26.192 -4.274  5.457  1.00 17.36 ? 90  GLN   A CB   1 
ATOM   1259 C CG   . GLN   A 1 110 ? 27.034 -4.728  4.325  1.00 27.48 ? 90  GLN   A CG   1 
ATOM   1260 C CD   . GLN   A 1 110 ? 27.309 -6.205  4.450  1.00 41.63 ? 90  GLN   A CD   1 
ATOM   1261 O OE1  . GLN   A 1 110 ? 28.351 -6.610  4.965  1.00 35.97 ? 90  GLN   A OE1  1 
ATOM   1262 N NE2  . GLN   A 1 110 ? 26.363 -7.022  4.009  1.00 40.94 ? 90  GLN   A NE2  1 
ATOM   1263 H H    . GLN   A 1 110 ? 27.550 -2.015  5.947  1.00 16.11 ? 90  GLN   A H    1 
ATOM   1264 H HA   . GLN   A 1 110 ? 25.192 -2.636  4.753  1.00 17.41 ? 90  GLN   A HA   1 
ATOM   1265 H HB2  . GLN   A 1 110 ? 26.681 -4.471  6.271  1.00 20.84 ? 90  GLN   A HB2  1 
ATOM   1266 H HB3  . GLN   A 1 110 ? 25.374 -4.795  5.428  1.00 20.84 ? 90  GLN   A HB3  1 
ATOM   1267 H HG2  . GLN   A 1 110 ? 26.571 -4.566  3.488  1.00 32.99 ? 90  GLN   A HG2  1 
ATOM   1268 H HG3  . GLN   A 1 110 ? 27.879 -4.251  4.334  1.00 32.99 ? 90  GLN   A HG3  1 
ATOM   1269 H HE21 . GLN   A 1 110 ? 25.640 -6.700  3.672  1.00 49.14 ? 90  GLN   A HE21 1 
ATOM   1270 H HE22 . GLN   A 1 110 ? 26.473 -7.873  4.058  1.00 49.14 ? 90  GLN   A HE22 1 
ATOM   1271 N N    . ILE   A 1 111 ? 23.948 -1.983  6.794  1.00 14.33 ? 91  ILE   A N    1 
ATOM   1272 C CA   . ILE   A 1 111 ? 23.241 -1.602  8.011  1.00 13.40 ? 91  ILE   A CA   1 
ATOM   1273 C C    . ILE   A 1 111 ? 22.322 -2.735  8.427  1.00 16.44 ? 91  ILE   A C    1 
ATOM   1274 O O    . ILE   A 1 111 ? 21.540 -3.245  7.617  1.00 19.59 ? 91  ILE   A O    1 
ATOM   1275 C CB   . ILE   A 1 111 ? 22.445 -0.305  7.810  1.00 14.06 ? 91  ILE   A CB   1 
ATOM   1276 C CG1  . ILE   A 1 111 ? 23.434 0.837   7.512  1.00 16.17 ? 91  ILE   A CG1  1 
ATOM   1277 C CG2  . ILE   A 1 111 ? 21.626 0.001   9.047  1.00 17.25 ? 91  ILE   A CG2  1 
ATOM   1278 C CD1  . ILE   A 1 111 ? 22.780 2.095   7.020  1.00 21.89 ? 91  ILE   A CD1  1 
ATOM   1279 H H    . ILE   A 1 111 ? 23.497 -1.853  6.074  1.00 17.20 ? 91  ILE   A H    1 
ATOM   1280 H HA   . ILE   A 1 111 ? 23.890 -1.463  8.718  1.00 16.09 ? 91  ILE   A HA   1 
ATOM   1281 H HB   . ILE   A 1 111 ? 21.833 -0.405  7.064  1.00 16.89 ? 91  ILE   A HB   1 
ATOM   1282 H HG12 . ILE   A 1 111 ? 23.914 1.053   8.327  1.00 19.42 ? 91  ILE   A HG12 1 
ATOM   1283 H HG13 . ILE   A 1 111 ? 24.056 0.540   6.830  1.00 19.42 ? 91  ILE   A HG13 1 
ATOM   1284 H HG21 . ILE   A 1 111 ? 21.343 0.929   9.017  1.00 20.72 ? 91  ILE   A HG21 1 
ATOM   1285 H HG22 . ILE   A 1 111 ? 20.851 -0.581  9.064  1.00 20.72 ? 91  ILE   A HG22 1 
ATOM   1286 H HG23 . ILE   A 1 111 ? 22.173 -0.153  9.833  1.00 20.72 ? 91  ILE   A HG23 1 
ATOM   1287 H HD11 . ILE   A 1 111 ? 23.467 2.709   6.715  1.00 26.28 ? 91  ILE   A HD11 1 
ATOM   1288 H HD12 . ILE   A 1 111 ? 22.184 1.875   6.287  1.00 26.28 ? 91  ILE   A HD12 1 
ATOM   1289 H HD13 . ILE   A 1 111 ? 22.278 2.496   7.747  1.00 26.28 ? 91  ILE   A HD13 1 
ATOM   1290 N N    . PHE   A 1 112 ? 22.417 -3.127  9.688  1.00 12.28 ? 92  PHE   A N    1 
ATOM   1291 C CA   . PHE   A 1 112 ? 21.574 -4.162  10.267 1.00 15.14 ? 92  PHE   A CA   1 
ATOM   1292 C C    . PHE   A 1 112 ? 20.645 -3.528  11.293 1.00 15.45 ? 92  PHE   A C    1 
ATOM   1293 O O    . PHE   A 1 112 ? 21.091 -3.041  12.343 1.00 13.88 ? 92  PHE   A O    1 
ATOM   1294 C CB   . PHE   A 1 112 ? 22.422 -5.256  10.910 1.00 12.63 ? 92  PHE   A CB   1 
ATOM   1295 C CG   . PHE   A 1 112 ? 23.312 -5.949  9.942  1.00 14.48 ? 92  PHE   A CG   1 
ATOM   1296 C CD1  . PHE   A 1 112 ? 22.844 -7.021  9.204  1.00 15.42 ? 92  PHE   A CD1  1 
ATOM   1297 C CD2  . PHE   A 1 112 ? 24.611 -5.525  9.757  1.00 16.43 ? 92  PHE   A CD2  1 
ATOM   1298 C CE1  . PHE   A 1 112 ? 23.663 -7.663  8.305  1.00 17.37 ? 92  PHE   A CE1  1 
ATOM   1299 C CE2  . PHE   A 1 112 ? 25.438 -6.165  8.853  1.00 15.82 ? 92  PHE   A CE2  1 
ATOM   1300 C CZ   . PHE   A 1 112 ? 24.957 -7.231  8.133  1.00 16.86 ? 92  PHE   A CZ   1 
ATOM   1301 H H    . PHE   A 1 112 ? 22.981 -2.797  10.247 1.00 14.74 ? 92  PHE   A H    1 
ATOM   1302 H HA   . PHE   A 1 112 ? 21.031 -4.555  9.566  1.00 18.18 ? 92  PHE   A HA   1 
ATOM   1303 H HB2  . PHE   A 1 112 ? 22.980 -4.858  11.597 1.00 15.17 ? 92  PHE   A HB2  1 
ATOM   1304 H HB3  . PHE   A 1 112 ? 21.834 -5.919  11.303 1.00 15.17 ? 92  PHE   A HB3  1 
ATOM   1305 H HD1  . PHE   A 1 112 ? 21.967 -7.310  9.316  1.00 18.51 ? 92  PHE   A HD1  1 
ATOM   1306 H HD2  . PHE   A 1 112 ? 24.933 -4.802  10.244 1.00 19.73 ? 92  PHE   A HD2  1 
ATOM   1307 H HE1  . PHE   A 1 112 ? 23.343 -8.386  7.816  1.00 20.86 ? 92  PHE   A HE1  1 
ATOM   1308 H HE2  . PHE   A 1 112 ? 26.314 -5.876  8.733  1.00 19.00 ? 92  PHE   A HE2  1 
ATOM   1309 H HZ   . PHE   A 1 112 ? 25.511 -7.665  7.525  1.00 20.24 ? 92  PHE   A HZ   1 
ATOM   1310 N N    . GLU   A 1 113 ? 19.356 -3.522  10.975 1.00 13.28 ? 93  GLU   A N    1 
ATOM   1311 C CA   . GLU   A 1 113 ? 18.334 -3.331  11.979 1.00 15.38 ? 93  GLU   A CA   1 
ATOM   1312 C C    . GLU   A 1 113 ? 18.323 -4.550  12.897 1.00 15.29 ? 93  GLU   A C    1 
ATOM   1313 O O    . GLU   A 1 113 ? 18.820 -5.624  12.541 1.00 17.41 ? 93  GLU   A O    1 
ATOM   1314 C CB   . GLU   A 1 113 ? 16.972 -3.166  11.319 1.00 22.36 ? 93  GLU   A CB   1 
ATOM   1315 C CG   . GLU   A 1 113 ? 16.996 -2.204  10.164 1.00 30.25 ? 93  GLU   A CG   1 
ATOM   1316 C CD   . GLU   A 1 113 ? 15.671 -2.152  9.443  1.00 29.40 ? 93  GLU   A CD   1 
ATOM   1317 O OE1  . GLU   A 1 113 ? 14.844 -3.062  9.665  1.00 31.69 ? 93  GLU   A OE1  1 
ATOM   1318 O OE2  . GLU   A 1 113 ? 15.453 -1.205  8.673  1.00 46.34 ? 93  GLU   A OE2  1 
ATOM   1319 H H    . GLU   A 1 113 ? 19.050 -3.627  10.178 1.00 15.95 ? 93  GLU   A H    1 
ATOM   1320 H HA   . GLU   A 1 113 ? 18.508 -2.533  12.502 1.00 18.47 ? 93  GLU   A HA   1 
ATOM   1321 H HB2  . GLU   A 1 113 ? 16.676 -4.028  10.986 1.00 26.85 ? 93  GLU   A HB2  1 
ATOM   1322 H HB3  . GLU   A 1 113 ? 16.342 -2.831  11.976 1.00 26.85 ? 93  GLU   A HB3  1 
ATOM   1323 H HG2  . GLU   A 1 113 ? 17.196 -1.314  10.494 1.00 36.31 ? 93  GLU   A HG2  1 
ATOM   1324 H HG3  . GLU   A 1 113 ? 17.675 -2.483  9.530  1.00 36.31 ? 93  GLU   A HG3  1 
ATOM   1325 N N    . THR   A 1 114 ? 17.771 -4.388  14.087 1.00 14.72 ? 94  THR   A N    1 
ATOM   1326 C CA   . THR   A 1 114 ? 17.612 -5.520  14.987 1.00 14.23 ? 94  THR   A CA   1 
ATOM   1327 C C    . THR   A 1 114 ? 16.200 -5.534  15.544 1.00 17.45 ? 94  THR   A C    1 
ATOM   1328 O O    . THR   A 1 114 ? 15.378 -4.670  15.239 1.00 18.94 ? 94  THR   A O    1 
ATOM   1329 C CB   . THR   A 1 114 ? 18.622 -5.517  16.140 1.00 13.71 ? 94  THR   A CB   1 
ATOM   1330 O OG1  . THR   A 1 114 ? 18.247 -4.565  17.136 1.00 15.59 ? 94  THR   A OG1  1 
ATOM   1331 C CG2  . THR   A 1 114 ? 20.030 -5.222  15.625 1.00 15.38 ? 94  THR   A CG2  1 
ATOM   1332 H H    . THR   A 1 114 ? 17.483 -3.638  14.395 1.00 17.67 ? 94  THR   A H    1 
ATOM   1333 H HA   . THR   A 1 114 ? 17.759 -6.322  14.461 1.00 17.09 ? 94  THR   A HA   1 
ATOM   1334 H HB   . THR   A 1 114 ? 18.634 -6.395  16.552 1.00 16.46 ? 94  THR   A HB   1 
ATOM   1335 H HG1  . THR   A 1 114 ? 18.324 -3.786  16.832 1.00 18.72 ? 94  THR   A HG1  1 
ATOM   1336 H HG21 . THR   A 1 114 ? 20.666 -5.261  16.356 1.00 18.47 ? 94  THR   A HG21 1 
ATOM   1337 H HG22 . THR   A 1 114 ? 20.281 -5.876  14.954 1.00 18.47 ? 94  THR   A HG22 1 
ATOM   1338 H HG23 . THR   A 1 114 ? 20.060 -4.337  15.229 1.00 18.47 ? 94  THR   A HG23 1 
ATOM   1339 N N    . GLN   A 1 115 ? 15.929 -6.522  16.386 1.00 16.39 ? 95  GLN   A N    1 
ATOM   1340 C CA   . GLN   A 1 115 ? 14.628 -6.579  17.042 1.00 18.83 ? 95  GLN   A CA   1 
ATOM   1341 C C    . GLN   A 1 115 ? 14.429 -5.413  17.996 1.00 21.20 ? 95  GLN   A C    1 
ATOM   1342 O O    . GLN   A 1 115 ? 13.287 -5.112  18.365 1.00 22.07 ? 95  GLN   A O    1 
ATOM   1343 C CB   . GLN   A 1 115 ? 14.469 -7.900  17.800 1.00 17.81 ? 95  GLN   A CB   1 
ATOM   1344 C CG   . GLN   A 1 115 ? 15.311 -8.018  19.051 1.00 15.41 ? 95  GLN   A CG   1 
ATOM   1345 C CD   . GLN   A 1 115 ? 16.648 -8.674  18.790 1.00 20.24 ? 95  GLN   A CD   1 
ATOM   1346 O OE1  . GLN   A 1 115 ? 17.218 -8.524  17.723 1.00 16.37 ? 95  GLN   A OE1  1 
ATOM   1347 N NE2  . GLN   A 1 115 ? 17.147 -9.427  19.768 1.00 24.07 ? 95  GLN   A NE2  1 
ATOM   1348 H H    . GLN   A 1 115 ? 16.468 -7.159  16.591 1.00 19.68 ? 95  GLN   A H    1 
ATOM   1349 H HA   . GLN   A 1 115 ? 13.935 -6.545  16.364 1.00 22.61 ? 95  GLN   A HA   1 
ATOM   1350 H HB2  . GLN   A 1 115 ? 13.541 -7.993  18.064 1.00 21.38 ? 95  GLN   A HB2  1 
ATOM   1351 H HB3  . GLN   A 1 115 ? 14.721 -8.626  17.209 1.00 21.38 ? 95  GLN   A HB3  1 
ATOM   1352 H HG2  . GLN   A 1 115 ? 15.476 -7.130  19.407 1.00 18.50 ? 95  GLN   A HG2  1 
ATOM   1353 H HG3  . GLN   A 1 115 ? 14.835 -8.554  19.704 1.00 18.50 ? 95  GLN   A HG3  1 
ATOM   1354 H HE21 . GLN   A 1 115 ? 16.711 -9.520  20.504 1.00 28.90 ? 95  GLN   A HE21 1 
ATOM   1355 H HE22 . GLN   A 1 115 ? 17.905 -9.819  19.665 1.00 28.90 ? 95  GLN   A HE22 1 
ATOM   1356 N N    . ASP   A 1 116 ? 15.517 -4.766  18.410 1.00 17.16 ? 96  ASP   A N    1 
ATOM   1357 C CA   . ASP   A 1 116 ? 15.454 -3.575  19.248 1.00 17.34 ? 96  ASP   A CA   1 
ATOM   1358 C C    . ASP   A 1 116 ? 15.415 -2.390  18.297 1.00 18.35 ? 96  ASP   A C    1 
ATOM   1359 O O    . ASP   A 1 116 ? 16.401 -2.150  17.586 1.00 16.99 ? 96  ASP   A O    1 
ATOM   1360 C CB   . ASP   A 1 116 ? 16.669 -3.500  20.160 1.00 15.05 ? 96  ASP   A CB   1 
ATOM   1361 C CG   . ASP   A 1 116 ? 16.644 -2.300  21.088 1.00 16.29 ? 96  ASP   A CG   1 
ATOM   1362 O OD1  . ASP   A 1 116 ? 15.870 -1.353  20.840 1.00 19.96 ? 96  ASP   A OD1  1 
ATOM   1363 O OD2  . ASP   A 1 116 ? 17.415 -2.310  22.065 1.00 21.08 ? 96  ASP   A OD2  1 
ATOM   1364 H H    . ASP   A 1 116 ? 16.320 -5.004  18.214 1.00 20.60 ? 96  ASP   A H    1 
ATOM   1365 H HA   . ASP   A 1 116 ? 14.666 -3.576  19.813 1.00 20.82 ? 96  ASP   A HA   1 
ATOM   1366 H HB2  . ASP   A 1 116 ? 16.700 -4.300  20.708 1.00 18.07 ? 96  ASP   A HB2  1 
ATOM   1367 H HB3  . ASP   A 1 116 ? 17.469 -3.439  19.615 1.00 18.07 ? 96  ASP   A HB3  1 
ATOM   1368 N N    . PRO   A 1 117 ? 14.302 -1.655  18.199 1.00 17.38 ? 97  PRO   A N    1 
ATOM   1369 C CA   . PRO   A 1 117 ? 14.246 -0.544  17.236 1.00 16.00 ? 97  PRO   A CA   1 
ATOM   1370 C C    . PRO   A 1 117 ? 15.273 0.533   17.519 1.00 14.01 ? 97  PRO   A C    1 
ATOM   1371 O O    . PRO   A 1 117 ? 15.532 1.361   16.645 1.00 17.84 ? 97  PRO   A O    1 
ATOM   1372 C CB   . PRO   A 1 117 ? 12.814 -0.005  17.403 1.00 23.64 ? 97  PRO   A CB   1 
ATOM   1373 C CG   . PRO   A 1 117 ? 12.441 -0.364  18.816 1.00 23.18 ? 97  PRO   A CG   1 
ATOM   1374 C CD   . PRO   A 1 117 ? 13.110 -1.699  19.074 1.00 20.92 ? 97  PRO   A CD   1 
ATOM   1375 H HA   . PRO   A 1 117 ? 14.357 -0.872  16.330 1.00 19.22 ? 97  PRO   A HA   1 
ATOM   1376 H HB2  . PRO   A 1 117 ? 12.804 0.956   17.272 1.00 28.38 ? 97  PRO   A HB2  1 
ATOM   1377 H HB3  . PRO   A 1 117 ? 12.222 -0.434  16.766 1.00 28.38 ? 97  PRO   A HB3  1 
ATOM   1378 H HG2  . PRO   A 1 117 ? 12.772 0.313   19.427 1.00 27.83 ? 97  PRO   A HG2  1 
ATOM   1379 H HG3  . PRO   A 1 117 ? 11.477 -0.439  18.894 1.00 27.83 ? 97  PRO   A HG3  1 
ATOM   1380 H HD2  . PRO   A 1 117 ? 13.368 -1.782  20.006 1.00 25.12 ? 97  PRO   A HD2  1 
ATOM   1381 H HD3  . PRO   A 1 117 ? 12.526 -2.432  18.826 1.00 25.12 ? 97  PRO   A HD3  1 
ATOM   1382 N N    . ASN   A 1 118 ? 15.867 0.530   18.705 1.00 18.33 ? 98  ASN   A N    1 
ATOM   1383 C CA   . ASN   A 1 118 ? 16.870 1.500   19.101 1.00 17.26 ? 98  ASN   A CA   1 
ATOM   1384 C C    . ASN   A 1 118 ? 18.279 0.935   19.080 1.00 15.80 ? 98  ASN   A C    1 
ATOM   1385 O O    . ASN   A 1 118 ? 19.182 1.546   19.652 1.00 19.14 ? 98  ASN   A O    1 
ATOM   1386 C CB   . ASN   A 1 118 ? 16.556 2.025   20.493 1.00 16.63 ? 98  ASN   A CB   1 
ATOM   1387 C CG   . ASN   A 1 118 ? 15.339 2.904   20.500 1.00 21.65 ? 98  ASN   A CG   1 
ATOM   1388 O OD1  . ASN   A 1 118 ? 15.263 3.873   19.753 1.00 21.99 ? 98  ASN   A OD1  1 
ATOM   1389 N ND2  . ASN   A 1 118 ? 14.367 2.569   21.347 1.00 29.44 ? 98  ASN   A ND2  1 
ATOM   1390 H H    . ASN   A 1 118 ? 15.698 -0.048  19.319 1.00 22.00 ? 98  ASN   A H    1 
ATOM   1391 H HA   . ASN   A 1 118 ? 16.840 2.242   18.477 1.00 20.73 ? 98  ASN   A HA   1 
ATOM   1392 H HB2  . ASN   A 1 118 ? 16.392 1.277   21.087 1.00 19.97 ? 98  ASN   A HB2  1 
ATOM   1393 H HB3  . ASN   A 1 118 ? 17.308 2.547   20.815 1.00 19.97 ? 98  ASN   A HB3  1 
ATOM   1394 H HD21 . ASN   A 1 118 ? 13.650 3.042   21.388 1.00 35.34 ? 98  ASN   A HD21 1 
ATOM   1395 H HD22 . ASN   A 1 118 ? 14.457 1.879   21.853 1.00 35.34 ? 98  ASN   A HD22 1 
ATOM   1396 N N    . TRP   A 1 119 ? 18.494 -0.216  18.451 1.00 15.15 ? 99  TRP   A N    1 
ATOM   1397 C CA   . TRP   A 1 119 ? 19.832 -0.786  18.363 1.00 12.96 ? 99  TRP   A CA   1 
ATOM   1398 C C    . TRP   A 1 119 ? 20.094 -1.230  16.930 1.00 14.42 ? 99  TRP   A C    1 
ATOM   1399 O O    . TRP   A 1 119 ? 19.334 -2.026  16.364 1.00 15.68 ? 99  TRP   A O    1 
ATOM   1400 C CB   . TRP   A 1 119 ? 19.993 -1.948  19.339 1.00 13.91 ? 99  TRP   A CB   1 
ATOM   1401 C CG   . TRP   A 1 119 ? 21.407 -2.234  19.769 1.00 14.87 ? 99  TRP   A CG   1 
ATOM   1402 C CD1  . TRP   A 1 119 ? 22.549 -2.028  19.051 1.00 14.85 ? 99  TRP   A CD1  1 
ATOM   1403 C CD2  . TRP   A 1 119 ? 21.819 -2.777  21.026 1.00 14.61 ? 99  TRP   A CD2  1 
ATOM   1404 N NE1  . TRP   A 1 119 ? 23.641 -2.423  19.781 1.00 14.15 ? 99  TRP   A NE1  1 
ATOM   1405 C CE2  . TRP   A 1 119 ? 23.221 -2.884  20.999 1.00 14.48 ? 99  TRP   A CE2  1 
ATOM   1406 C CE3  . TRP   A 1 119 ? 21.136 -3.188  22.173 1.00 17.13 ? 99  TRP   A CE3  1 
ATOM   1407 C CZ2  . TRP   A 1 119 ? 23.954 -3.379  22.072 1.00 17.98 ? 99  TRP   A CZ2  1 
ATOM   1408 C CZ3  . TRP   A 1 119 ? 21.855 -3.683  23.231 1.00 18.55 ? 99  TRP   A CZ3  1 
ATOM   1409 C CH2  . TRP   A 1 119 ? 23.253 -3.772  23.182 1.00 20.63 ? 99  TRP   A CH2  1 
ATOM   1410 H H    . TRP   A 1 119 ? 17.882 -0.683  18.068 1.00 18.19 ? 99  TRP   A H    1 
ATOM   1411 H HA   . TRP   A 1 119 ? 20.490 -0.107  18.583 1.00 15.56 ? 99  TRP   A HA   1 
ATOM   1412 H HB2  . TRP   A 1 119 ? 19.481 -1.750  20.139 1.00 16.71 ? 99  TRP   A HB2  1 
ATOM   1413 H HB3  . TRP   A 1 119 ? 19.651 -2.752  18.917 1.00 16.71 ? 99  TRP   A HB3  1 
ATOM   1414 H HD1  . TRP   A 1 119 ? 22.582 -1.672  18.192 1.00 17.83 ? 99  TRP   A HD1  1 
ATOM   1415 H HE1  . TRP   A 1 119 ? 24.458 -2.386  19.515 1.00 16.99 ? 99  TRP   A HE1  1 
ATOM   1416 H HE3  . TRP   A 1 119 ? 20.209 -3.126  22.219 1.00 20.57 ? 99  TRP   A HE3  1 
ATOM   1417 H HZ2  . TRP   A 1 119 ? 24.881 -3.441  22.038 1.00 21.59 ? 99  TRP   A HZ2  1 
ATOM   1418 H HZ3  . TRP   A 1 119 ? 21.407 -3.965  23.995 1.00 22.28 ? 99  TRP   A HZ3  1 
ATOM   1419 H HH2  . TRP   A 1 119 ? 23.714 -4.105  23.917 1.00 24.77 ? 99  TRP   A HH2  1 
ATOM   1420 N N    . PHE   A 1 120 ? 21.158 -0.695  16.345 1.00 13.61 ? 100 PHE   A N    1 
ATOM   1421 C CA   . PHE   A 1 120 ? 21.602 -1.026  15.000 1.00 13.15 ? 100 PHE   A CA   1 
ATOM   1422 C C    . PHE   A 1 120 ? 23.045 -1.487  15.050 1.00 13.03 ? 100 PHE   A C    1 
ATOM   1423 O O    . PHE   A 1 120 ? 23.820 -1.059  15.909 1.00 11.99 ? 100 PHE   A O    1 
ATOM   1424 C CB   . PHE   A 1 120 ? 21.511 0.161   14.051 1.00 13.51 ? 100 PHE   A CB   1 
ATOM   1425 C CG   . PHE   A 1 120 ? 20.121 0.527   13.699 1.00 14.08 ? 100 PHE   A CG   1 
ATOM   1426 C CD1  . PHE   A 1 120 ? 19.298 1.066   14.660 1.00 19.15 ? 100 PHE   A CD1  1 
ATOM   1427 C CD2  . PHE   A 1 120 ? 19.631 0.305   12.435 1.00 15.19 ? 100 PHE   A CD2  1 
ATOM   1428 C CE1  . PHE   A 1 120 ? 18.002 1.384   14.365 1.00 20.26 ? 100 PHE   A CE1  1 
ATOM   1429 C CE2  . PHE   A 1 120 ? 18.326 0.628   12.125 1.00 18.60 ? 100 PHE   A CE2  1 
ATOM   1430 C CZ   . PHE   A 1 120 ? 17.521 1.170   13.106 1.00 17.82 ? 100 PHE   A CZ   1 
ATOM   1431 H H    . PHE   A 1 120 ? 21.661 -0.111  16.725 1.00 16.35 ? 100 PHE   A H    1 
ATOM   1432 H HA   . PHE   A 1 120 ? 21.039 -1.736  14.652 1.00 15.79 ? 100 PHE   A HA   1 
ATOM   1433 H HB2  . PHE   A 1 120 ? 21.923 0.931   14.473 1.00 16.22 ? 100 PHE   A HB2  1 
ATOM   1434 H HB3  . PHE   A 1 120 ? 21.978 -0.057  13.230 1.00 16.22 ? 100 PHE   A HB3  1 
ATOM   1435 H HD1  . PHE   A 1 120 ? 19.626 1.215   15.518 1.00 22.99 ? 100 PHE   A HD1  1 
ATOM   1436 H HD2  . PHE   A 1 120 ? 20.183 -0.065  11.784 1.00 18.25 ? 100 PHE   A HD2  1 
ATOM   1437 H HE1  . PHE   A 1 120 ? 17.450 1.746   15.020 1.00 24.32 ? 100 PHE   A HE1  1 
ATOM   1438 H HE2  . PHE   A 1 120 ? 17.994 0.483   11.269 1.00 22.33 ? 100 PHE   A HE2  1 
ATOM   1439 H HZ   . PHE   A 1 120 ? 16.640 1.392   12.906 1.00 21.40 ? 100 PHE   A HZ   1 
ATOM   1440 N N    . TRP   A 1 121 ? 23.406 -2.345  14.106 1.00 12.85 ? 101 TRP   A N    1 
ATOM   1441 C CA   . TRP   A 1 121 ? 24.795 -2.677  13.861 1.00 11.79 ? 101 TRP   A CA   1 
ATOM   1442 C C    . TRP   A 1 121 ? 25.120 -2.339  12.420 1.00 12.58 ? 101 TRP   A C    1 
ATOM   1443 O O    . TRP   A 1 121 ? 24.264 -2.418  11.542 1.00 15.42 ? 101 TRP   A O    1 
ATOM   1444 C CB   . TRP   A 1 121 ? 25.083 -4.145  14.124 1.00 11.57 ? 101 TRP   A CB   1 
ATOM   1445 C CG   . TRP   A 1 121 ? 25.007 -4.474  15.553 1.00 13.24 ? 101 TRP   A CG   1 
ATOM   1446 C CD1  . TRP   A 1 121 ? 23.892 -4.812  16.255 1.00 15.22 ? 101 TRP   A CD1  1 
ATOM   1447 C CD2  . TRP   A 1 121 ? 26.090 -4.468  16.486 1.00 12.20 ? 101 TRP   A CD2  1 
ATOM   1448 N NE1  . TRP   A 1 121 ? 24.214 -5.031  17.562 1.00 13.36 ? 101 TRP   A NE1  1 
ATOM   1449 C CE2  . TRP   A 1 121 ? 25.557 -4.827  17.739 1.00 12.47 ? 101 TRP   A CE2  1 
ATOM   1450 C CE3  . TRP   A 1 121 ? 27.465 -4.206  16.383 1.00 13.62 ? 101 TRP   A CE3  1 
ATOM   1451 C CZ2  . TRP   A 1 121 ? 26.347 -4.935  18.887 1.00 12.75 ? 101 TRP   A CZ2  1 
ATOM   1452 C CZ3  . TRP   A 1 121 ? 28.241 -4.317  17.515 1.00 14.68 ? 101 TRP   A CZ3  1 
ATOM   1453 C CH2  . TRP   A 1 121 ? 27.678 -4.669  18.755 1.00 13.79 ? 101 TRP   A CH2  1 
ATOM   1454 H H    . TRP   A 1 121 ? 22.853 -2.752  13.588 1.00 15.44 ? 101 TRP   A H    1 
ATOM   1455 H HA   . TRP   A 1 121 ? 25.368 -2.164  14.451 1.00 14.16 ? 101 TRP   A HA   1 
ATOM   1456 H HB2  . TRP   A 1 121 ? 24.430 -4.687  13.653 1.00 13.90 ? 101 TRP   A HB2  1 
ATOM   1457 H HB3  . TRP   A 1 121 ? 25.976 -4.355  13.811 1.00 13.90 ? 101 TRP   A HB3  1 
ATOM   1458 H HD1  . TRP   A 1 121 ? 23.037 -4.882  15.897 1.00 18.28 ? 101 TRP   A HD1  1 
ATOM   1459 H HE1  . TRP   A 1 121 ? 23.660 -5.262  18.178 1.00 16.05 ? 101 TRP   A HE1  1 
ATOM   1460 H HE3  . TRP   A 1 121 ? 27.843 -3.963  15.569 1.00 16.35 ? 101 TRP   A HE3  1 
ATOM   1461 H HZ2  . TRP   A 1 121 ? 25.981 -5.178  19.706 1.00 15.31 ? 101 TRP   A HZ2  1 
ATOM   1462 H HZ3  . TRP   A 1 121 ? 29.156 -4.157  17.459 1.00 17.63 ? 101 TRP   A HZ3  1 
ATOM   1463 H HH2  . TRP   A 1 121 ? 28.227 -4.722  19.504 1.00 16.56 ? 101 TRP   A HH2  1 
ATOM   1464 N N    . VAL   A 1 122 ? 26.362 -1.956  12.179 1.00 12.76 ? 102 VAL   A N    1 
ATOM   1465 C CA   . VAL   A 1 122 ? 26.837 -1.666  10.838 1.00 11.20 ? 102 VAL   A CA   1 
ATOM   1466 C C    . VAL   A 1 122 ? 28.140 -2.417  10.630 1.00 11.42 ? 102 VAL   A C    1 
ATOM   1467 O O    . VAL   A 1 122 ? 29.055 -2.340  11.460 1.00 13.02 ? 102 VAL   A O    1 
ATOM   1468 C CB   . VAL   A 1 122 ? 27.058 -0.166  10.595 1.00 10.80 ? 102 VAL   A CB   1 
ATOM   1469 C CG1  . VAL   A 1 122 ? 27.599 0.052   9.191  1.00 13.33 ? 102 VAL   A CG1  1 
ATOM   1470 C CG2  . VAL   A 1 122 ? 25.768 0.591   10.810 1.00 14.94 ? 102 VAL   A CG2  1 
ATOM   1471 H H    . VAL   A 1 122 ? 26.961 -1.855  12.789 1.00 15.32 ? 102 VAL   A H    1 
ATOM   1472 H HA   . VAL   A 1 122 ? 26.176 -1.980  10.201 1.00 13.45 ? 102 VAL   A HA   1 
ATOM   1473 H HB   . VAL   A 1 122 ? 27.709 0.178   11.226 1.00 12.97 ? 102 VAL   A HB   1 
ATOM   1474 H HG11 . VAL   A 1 122 ? 27.583 1.001   8.990  1.00 16.01 ? 102 VAL   A HG11 1 
ATOM   1475 H HG12 . VAL   A 1 122 ? 28.510 -0.280  9.149  1.00 16.01 ? 102 VAL   A HG12 1 
ATOM   1476 H HG13 . VAL   A 1 122 ? 27.042 -0.429  8.559  1.00 16.01 ? 102 VAL   A HG13 1 
ATOM   1477 H HG21 . VAL   A 1 122 ? 25.920 1.532   10.632 1.00 17.95 ? 102 VAL   A HG21 1 
ATOM   1478 H HG22 . VAL   A 1 122 ? 25.094 0.244   10.205 1.00 17.95 ? 102 VAL   A HG22 1 
ATOM   1479 H HG23 . VAL   A 1 122 ? 25.480 0.470   11.729 1.00 17.95 ? 102 VAL   A HG23 1 
ATOM   1480 N N    . GLU   A 1 123 ? 28.220 -3.157  9.527  1.00 10.70 ? 103 GLU   A N    1 
ATOM   1481 C CA   . GLU   A 1 123 ? 29.473 -3.731  9.071  1.00 11.15 ? 103 GLU   A CA   1 
ATOM   1482 C C    . GLU   A 1 123 ? 29.949 -2.908  7.886  1.00 13.03 ? 103 GLU   A C    1 
ATOM   1483 O O    . GLU   A 1 123 ? 29.170 -2.618  6.985  1.00 14.11 ? 103 GLU   A O    1 
ATOM   1484 C CB   . GLU   A 1 123 ? 29.316 -5.194  8.662  1.00 11.36 ? 103 GLU   A CB   1 
ATOM   1485 C CG   . GLU   A 1 123 ? 30.642 -5.788  8.249  1.00 12.82 ? 103 GLU   A CG   1 
ATOM   1486 C CD   . GLU   A 1 123 ? 30.590 -7.262  7.970  1.00 15.51 ? 103 GLU   A CD   1 
ATOM   1487 O OE1  . GLU   A 1 123 ? 29.485 -7.851  7.913  1.00 15.08 ? 103 GLU   A OE1  1 
ATOM   1488 O OE2  . GLU   A 1 123 ? 31.682 -7.846  7.798  1.00 17.50 ? 103 GLU   A OE2  1 
ATOM   1489 H H    . GLU   A 1 123 ? 27.548 -3.340  9.022  1.00 12.85 ? 103 GLU   A H    1 
ATOM   1490 H HA   . GLU   A 1 123 ? 30.130 -3.702  9.785  1.00 13.39 ? 103 GLU   A HA   1 
ATOM   1491 H HB2  . GLU   A 1 123 ? 28.972 -5.704  9.412  1.00 13.65 ? 103 GLU   A HB2  1 
ATOM   1492 H HB3  . GLU   A 1 123 ? 28.705 -5.255  7.911  1.00 13.65 ? 103 GLU   A HB3  1 
ATOM   1493 H HG2  . GLU   A 1 123 ? 30.943 -5.345  7.441  1.00 15.39 ? 103 GLU   A HG2  1 
ATOM   1494 H HG3  . GLU   A 1 123 ? 31.283 -5.645  8.964  1.00 15.39 ? 103 GLU   A HG3  1 
ATOM   1495 N N    . CYS   A 1 124 ? 31.216 -2.522  7.890  1.00 12.23 ? 104 CYS   A N    1 
ATOM   1496 C CA   . CYS   A 1 124 ? 31.707 -1.721  6.786  1.00 11.42 ? 104 CYS   A CA   1 
ATOM   1497 C C    . CYS   A 1 124 ? 33.221 -1.794  6.748  1.00 13.18 ? 104 CYS   A C    1 
ATOM   1498 O O    . CYS   A 1 124 ? 33.863 -2.390  7.611  1.00 13.98 ? 104 CYS   A O    1 
ATOM   1499 C CB   . CYS   A 1 124 ? 31.227 -0.280  6.896  1.00 13.23 ? 104 CYS   A CB   1 
ATOM   1500 S SG   . CYS   A 1 124 ? 31.990 0.655   8.234  1.00 15.21 ? 104 CYS   A SG   1 
ATOM   1501 H H    . CYS   A 1 124 ? 31.792 -2.706  8.503  1.00 14.68 ? 104 CYS   A H    1 
ATOM   1502 H HA   . CYS   A 1 124 ? 31.376 -2.095  5.955  1.00 13.72 ? 104 CYS   A HA   1 
ATOM   1503 H HB2  . CYS   A 1 124 ? 31.428 0.178   6.065  1.00 15.88 ? 104 CYS   A HB2  1 
ATOM   1504 H HB3  . CYS   A 1 124 ? 30.269 -0.284  7.049  1.00 15.88 ? 104 CYS   A HB3  1 
ATOM   1505 H HG   . CYS   A 1 124 ? 33.138 0.866   7.957  1.00 18.27 ? 104 CYS   A HG   1 
ATOM   1506 N N    . ARG   A 1 125 ? 33.779 -1.193  5.706  1.00 14.50 ? 105 ARG   A N    1 
ATOM   1507 C CA   . ARG   A 1 125 ? 35.203 -0.928  5.648  1.00 17.04 ? 105 ARG   A CA   1 
ATOM   1508 C C    . ARG   A 1 125 ? 35.412 0.560   5.876  1.00 13.41 ? 105 ARG   A C    1 
ATOM   1509 O O    . ARG   A 1 125 ? 34.489 1.365   5.762  1.00 16.24 ? 105 ARG   A O    1 
ATOM   1510 C CB   . ARG   A 1 125 ? 35.785 -1.373  4.306  1.00 22.32 ? 105 ARG   A CB   1 
ATOM   1511 C CG   . ARG   A 1 125 ? 35.502 -2.833  3.986  1.00 32.07 ? 105 ARG   A CG   1 
ATOM   1512 C CD   . ARG   A 1 125 ? 36.341 -3.782  4.828  1.00 37.69 ? 105 ARG   A CD   1 
ATOM   1513 N NE   . ARG   A 1 125 ? 36.074 -5.174  4.484  1.00 55.42 ? 105 ARG   A NE   1 
ATOM   1514 C CZ   . ARG   A 1 125 ? 36.930 -6.170  4.672  1.00 57.99 ? 105 ARG   A CZ   1 
ATOM   1515 N NH1  . ARG   A 1 125 ? 38.144 -5.954  5.153  1.00 44.69 ? 105 ARG   A NH1  1 
ATOM   1516 N NH2  . ARG   A 1 125 ? 36.559 -7.411  4.367  1.00 59.10 ? 105 ARG   A NH2  1 
ATOM   1517 H H    . ARG   A 1 125 ? 33.345 -0.928  5.013  1.00 17.41 ? 105 ARG   A H    1 
ATOM   1518 H HA   . ARG   A 1 125 ? 35.683 -1.420  6.333  1.00 20.46 ? 105 ARG   A HA   1 
ATOM   1519 H HB2  . ARG   A 1 125 ? 35.397 -0.832  3.600  1.00 26.80 ? 105 ARG   A HB2  1 
ATOM   1520 H HB3  . ARG   A 1 125 ? 36.747 -1.253  4.325  1.00 26.80 ? 105 ARG   A HB3  1 
ATOM   1521 H HG2  . ARG   A 1 125 ? 34.567 -3.021  4.162  1.00 38.50 ? 105 ARG   A HG2  1 
ATOM   1522 H HG3  . ARG   A 1 125 ? 35.704 -2.999  3.052  1.00 38.50 ? 105 ARG   A HG3  1 
ATOM   1523 H HD2  . ARG   A 1 125 ? 37.282 -3.604  4.672  1.00 45.24 ? 105 ARG   A HD2  1 
ATOM   1524 H HD3  . ARG   A 1 125 ? 36.130 -3.653  5.766  1.00 45.24 ? 105 ARG   A HD3  1 
ATOM   1525 H HE   . ARG   A 1 125 ? 35.310 -5.362  4.136  1.00 66.51 ? 105 ARG   A HE   1 
ATOM   1526 H HH11 . ARG   A 1 125 ? 38.393 -5.155  5.351  1.00 53.64 ? 105 ARG   A HH11 1 
ATOM   1527 H HH12 . ARG   A 1 125 ? 38.684 -6.614  5.268  1.00 53.64 ? 105 ARG   A HH12 1 
ATOM   1528 H HH21 . ARG   A 1 125 ? 35.772 -7.559  4.052  1.00 70.93 ? 105 ARG   A HH21 1 
ATOM   1529 H HH22 . ARG   A 1 125 ? 37.105 -8.064  4.484  1.00 70.93 ? 105 ARG   A HH22 1 
ATOM   1530 N N    . GLY   A 1 126 ? 36.627 0.914   6.230  1.00 14.58 ? 106 GLY   A N    1 
ATOM   1531 C CA   . GLY   A 1 126 ? 37.001 2.308   6.324  1.00 17.20 ? 106 GLY   A CA   1 
ATOM   1532 C C    . GLY   A 1 126 ? 38.409 2.465   5.815  1.00 12.73 ? 106 GLY   A C    1 
ATOM   1533 O O    . GLY   A 1 126 ? 39.259 1.593   6.000  1.00 15.21 ? 106 GLY   A O    1 
ATOM   1534 H H    . GLY   A 1 126 ? 37.260 0.364   6.421  1.00 17.51 ? 106 GLY   A H    1 
ATOM   1535 H HA2  . GLY   A 1 126 ? 36.403 2.853   5.788  1.00 20.65 ? 106 GLY   A HA2  1 
ATOM   1536 H HA3  . GLY   A 1 126 ? 36.958 2.606   7.246  1.00 20.65 ? 106 GLY   A HA3  1 
ATOM   1537 N N    . GLU   A 1 127 ? 38.647 3.583   5.152  1.00 14.06 ? 107 GLU   A N    1 
ATOM   1538 C CA   . GLU   A 1 127 ? 40.012 3.822   4.744  1.00 16.07 ? 107 GLU   A CA   1 
ATOM   1539 C C    . GLU   A 1 127 ? 40.276 5.294   4.530  1.00 12.47 ? 107 GLU   A C    1 
ATOM   1540 O O    . GLU   A 1 127 ? 39.376 6.091   4.249  1.00 14.40 ? 107 GLU   A O    1 
ATOM   1541 C CB   . GLU   A 1 127 ? 40.352 3.024   3.482  1.00 27.66 ? 107 GLU   A CB   1 
ATOM   1542 C CG   . GLU   A 1 127 ? 39.674 3.435   2.185  1.00 24.91 ? 107 GLU   A CG   1 
ATOM   1543 C CD   . GLU   A 1 127 ? 40.261 2.634   1.029  1.00 26.61 ? 107 GLU   A CD   1 
ATOM   1544 O OE1  . GLU   A 1 127 ? 40.007 1.416   0.984  1.00 25.01 ? 107 GLU   A OE1  1 
ATOM   1545 O OE2  . GLU   A 1 127 ? 41.023 3.218   0.246  1.00 25.56 ? 107 GLU   A OE2  1 
ATOM   1546 H H    . GLU   A 1 127 ? 38.067 4.181   4.940  1.00 16.89 ? 107 GLU   A H    1 
ATOM   1547 H HA   . GLU   A 1 127 ? 40.596 3.549   5.469  1.00 19.29 ? 107 GLU   A HA   1 
ATOM   1548 H HB2  . GLU   A 1 127 ? 41.308 3.096   3.334  1.00 33.21 ? 107 GLU   A HB2  1 
ATOM   1549 H HB3  . GLU   A 1 127 ? 40.111 2.098   3.642  1.00 33.21 ? 107 GLU   A HB3  1 
ATOM   1550 H HG2  . GLU   A 1 127 ? 38.723 3.256   2.240  1.00 29.91 ? 107 GLU   A HG2  1 
ATOM   1551 H HG3  . GLU   A 1 127 ? 39.825 4.379   2.020  1.00 29.91 ? 107 GLU   A HG3  1 
ATOM   1552 N N    . GLY   A 1 128 ? 41.544 5.624   4.663  1.00 15.05 ? 108 GLY   A N    1 
ATOM   1553 C CA   . GLY   A 1 128 ? 42.006 6.968   4.415  1.00 15.85 ? 108 GLY   A CA   1 
ATOM   1554 C C    . GLY   A 1 128 ? 43.388 7.126   4.998  1.00 14.80 ? 108 GLY   A C    1 
ATOM   1555 O O    . GLY   A 1 128 ? 43.954 6.201   5.582  1.00 16.47 ? 108 GLY   A O    1 
ATOM   1556 H H    . GLY   A 1 128 ? 42.165 5.078   4.901  1.00 18.07 ? 108 GLY   A H    1 
ATOM   1557 H HA2  . GLY   A 1 128 ? 42.040 7.139   3.461  1.00 19.03 ? 108 GLY   A HA2  1 
ATOM   1558 H HA3  . GLY   A 1 128 ? 41.409 7.609   4.830  1.00 19.03 ? 108 GLY   A HA3  1 
ATOM   1559 N N    . ALA   A 1 129 ? 43.923 8.330   4.817  1.00 14.42 ? 109 ALA   A N    1 
ATOM   1560 C CA   . ALA   A 1 129 ? 45.215 8.647   5.384  1.00 14.30 ? 109 ALA   A CA   1 
ATOM   1561 C C    . ALA   A 1 129 ? 45.118 8.623   6.901  1.00 14.38 ? 109 ALA   A C    1 
ATOM   1562 O O    . ALA   A 1 129 ? 44.106 9.020   7.475  1.00 16.41 ? 109 ALA   A O    1 
ATOM   1563 C CB   . ALA   A 1 129 ? 45.678 10.026  4.927  1.00 17.32 ? 109 ALA   A CB   1 
ATOM   1564 H H    . ALA   A 1 129 ? 43.557 8.970   4.374  1.00 17.32 ? 109 ALA   A H    1 
ATOM   1565 H HA   . ALA   A 1 129 ? 45.871 7.996   5.089  1.00 17.17 ? 109 ALA   A HA   1 
ATOM   1566 H HB1  . ALA   A 1 129 ? 46.548 10.211  5.315  1.00 20.79 ? 109 ALA   A HB1  1 
ATOM   1567 H HB2  . ALA   A 1 129 ? 45.739 10.034  3.959  1.00 20.79 ? 109 ALA   A HB2  1 
ATOM   1568 H HB3  . ALA   A 1 129 ? 45.035 10.689  5.224  1.00 20.79 ? 109 ALA   A HB3  1 
ATOM   1569 N N    . ILE   A 1 130 ? 46.179 8.170   7.549  1.00 15.57 ? 110 ILE   A N    1 
ATOM   1570 C CA   . ILE   A 1 130 ? 46.324 8.296   8.997  1.00 12.45 ? 110 ILE   A CA   1 
ATOM   1571 C C    . ILE   A 1 130 ? 47.513 9.215   9.268  1.00 17.07 ? 110 ILE   A C    1 
ATOM   1572 O O    . ILE   A 1 130 ? 48.608 9.015   8.724  1.00 16.60 ? 110 ILE   A O    1 
ATOM   1573 C CB   . ILE   A 1 130 ? 46.468 6.925   9.682  1.00 14.45 ? 110 ILE   A CB   1 
ATOM   1574 C CG1  . ILE   A 1 130 ? 46.499 7.103   11.199 1.00 15.88 ? 110 ILE   A CG1  1 
ATOM   1575 C CG2  . ILE   A 1 130 ? 47.678 6.167   9.171  1.00 14.80 ? 110 ILE   A CG2  1 
ATOM   1576 C CD1  . ILE   A 1 130 ? 46.310 5.811   11.962 1.00 16.31 ? 110 ILE   A CD1  1 
ATOM   1577 H H    . ILE   A 1 130 ? 46.842 7.777   7.167  1.00 18.69 ? 110 ILE   A H    1 
ATOM   1578 H HA   . ILE   A 1 130 ? 45.533 8.714   9.372  1.00 14.96 ? 110 ILE   A HA   1 
ATOM   1579 H HB   . ILE   A 1 130 ? 45.693 6.386   9.457  1.00 17.36 ? 110 ILE   A HB   1 
ATOM   1580 H HG12 . ILE   A 1 130 ? 47.359 7.474   11.452 1.00 19.07 ? 110 ILE   A HG12 1 
ATOM   1581 H HG13 . ILE   A 1 130 ? 45.787 7.708   11.457 1.00 19.07 ? 110 ILE   A HG13 1 
ATOM   1582 H HG21 . ILE   A 1 130 ? 47.806 5.373   9.714  1.00 17.77 ? 110 ILE   A HG21 1 
ATOM   1583 H HG22 . ILE   A 1 130 ? 47.525 5.914   8.247  1.00 17.77 ? 110 ILE   A HG22 1 
ATOM   1584 H HG23 . ILE   A 1 130 ? 48.458 6.740   9.233  1.00 17.77 ? 110 ILE   A HG23 1 
ATOM   1585 H HD11 . ILE   A 1 130 ? 46.067 6.018   12.878 1.00 19.58 ? 110 ILE   A HD11 1 
ATOM   1586 H HD12 . ILE   A 1 130 ? 45.604 5.296   11.541 1.00 19.58 ? 110 ILE   A HD12 1 
ATOM   1587 H HD13 . ILE   A 1 130 ? 47.140 5.309   11.945 1.00 19.58 ? 110 ILE   A HD13 1 
ATOM   1588 N N    . VAL   A 1 131 ? 47.268 10.256  10.059 1.00 15.89 ? 111 VAL   A N    1 
ATOM   1589 C CA   . VAL   A 1 131 ? 48.205 11.347  10.291 1.00 17.52 ? 111 VAL   A CA   1 
ATOM   1590 C C    . VAL   A 1 131 ? 48.314 11.529  11.797 1.00 15.99 ? 111 VAL   A C    1 
ATOM   1591 O O    . VAL   A 1 131 ? 47.606 12.353  12.392 1.00 18.70 ? 111 VAL   A O    1 
ATOM   1592 C CB   . VAL   A 1 131 ? 47.735 12.627  9.584  1.00 18.20 ? 111 VAL   A CB   1 
ATOM   1593 C CG1  . VAL   A 1 131 ? 48.808 13.713  9.654  1.00 23.21 ? 111 VAL   A CG1  1 
ATOM   1594 C CG2  . VAL   A 1 131 ? 47.375 12.325  8.135  1.00 20.03 ? 111 VAL   A CG2  1 
ATOM   1595 H H    . VAL   A 1 131 ? 46.532 10.357  10.491 1.00 19.08 ? 111 VAL   A H    1 
ATOM   1596 H HA   . VAL   A 1 131 ? 49.083 11.134  9.939  1.00 21.04 ? 111 VAL   A HA   1 
ATOM   1597 H HB   . VAL   A 1 131 ? 46.945 12.962  10.036 1.00 21.85 ? 111 VAL   A HB   1 
ATOM   1598 H HG11 . VAL   A 1 131 ? 48.507 14.487  9.153  1.00 27.86 ? 111 VAL   A HG11 1 
ATOM   1599 H HG12 . VAL   A 1 131 ? 48.951 13.956  10.583 1.00 27.86 ? 111 VAL   A HG12 1 
ATOM   1600 H HG13 . VAL   A 1 131 ? 49.631 13.370  9.272  1.00 27.86 ? 111 VAL   A HG13 1 
ATOM   1601 H HG21 . VAL   A 1 131 ? 47.162 13.156  7.683  1.00 24.05 ? 111 VAL   A HG21 1 
ATOM   1602 H HG22 . VAL   A 1 131 ? 48.132 11.899  7.704  1.00 24.05 ? 111 VAL   A HG22 1 
ATOM   1603 H HG23 . VAL   A 1 131 ? 46.608 11.732  8.118  1.00 24.05 ? 111 VAL   A HG23 1 
ATOM   1604 N N    . PHE   A 1 132 ? 49.168 10.715  12.419 1.00 17.57 ? 112 PHE   A N    1 
ATOM   1605 C CA   . PHE   A 1 132 ? 49.427 10.752  13.850 1.00 17.13 ? 112 PHE   A CA   1 
ATOM   1606 C C    . PHE   A 1 132 ? 50.781 11.407  14.070 1.00 19.50 ? 112 PHE   A C    1 
ATOM   1607 O O    . PHE   A 1 132 ? 51.779 10.916  13.521 1.00 18.60 ? 112 PHE   A O    1 
ATOM   1608 C CB   . PHE   A 1 132 ? 49.432 9.353   14.457 1.00 16.98 ? 112 PHE   A CB   1 
ATOM   1609 C CG   . PHE   A 1 132 ? 48.070 8.771   14.726 1.00 15.98 ? 112 PHE   A CG   1 
ATOM   1610 C CD1  . PHE   A 1 132 ? 46.913 9.358   14.247 1.00 18.23 ? 112 PHE   A CD1  1 
ATOM   1611 C CD2  . PHE   A 1 132 ? 47.970 7.614   15.484 1.00 20.29 ? 112 PHE   A CD2  1 
ATOM   1612 C CE1  . PHE   A 1 132 ? 45.671 8.788   14.516 1.00 20.10 ? 112 PHE   A CE1  1 
ATOM   1613 C CE2  . PHE   A 1 132 ? 46.741 7.044   15.749 1.00 18.65 ? 112 PHE   A CE2  1 
ATOM   1614 C CZ   . PHE   A 1 132 ? 45.595 7.631   15.272 1.00 18.00 ? 112 PHE   A CZ   1 
ATOM   1615 H H    . PHE   A 1 132 ? 49.625 10.110  12.013 1.00 21.10 ? 112 PHE   A H    1 
ATOM   1616 H HA   . PHE   A 1 132 ? 48.729 11.264  14.288 1.00 20.57 ? 112 PHE   A HA   1 
ATOM   1617 H HB2  . PHE   A 1 132 ? 49.888 8.754   13.845 1.00 20.39 ? 112 PHE   A HB2  1 
ATOM   1618 H HB3  . PHE   A 1 132 ? 49.905 9.386   15.303 1.00 20.39 ? 112 PHE   A HB3  1 
ATOM   1619 H HD1  . PHE   A 1 132 ? 46.965 10.138  13.742 1.00 21.89 ? 112 PHE   A HD1  1 
ATOM   1620 H HD2  . PHE   A 1 132 ? 48.741 7.216   15.818 1.00 24.36 ? 112 PHE   A HD2  1 
ATOM   1621 H HE1  . PHE   A 1 132 ? 44.896 9.183   14.189 1.00 24.14 ? 112 PHE   A HE1  1 
ATOM   1622 H HE2  . PHE   A 1 132 ? 46.689 6.262   16.250 1.00 22.39 ? 112 PHE   A HE2  1 
ATOM   1623 H HZ   . PHE   A 1 132 ? 44.767 7.251   15.458 1.00 21.61 ? 112 PHE   A HZ   1 
ATOM   1624 N N    . PRO   A 1 133 ? 50.876 12.486  14.845 1.00 19.22 ? 113 PRO   A N    1 
ATOM   1625 C CA   . PRO   A 1 133 ? 52.186 13.109  15.082 1.00 18.92 ? 113 PRO   A CA   1 
ATOM   1626 C C    . PRO   A 1 133 ? 53.190 12.112  15.634 1.00 19.77 ? 113 PRO   A C    1 
ATOM   1627 O O    . PRO   A 1 133 ? 52.922 11.407  16.617 1.00 22.05 ? 113 PRO   A O    1 
ATOM   1628 C CB   . PRO   A 1 133 ? 51.878 14.210  16.100 1.00 20.77 ? 113 PRO   A CB   1 
ATOM   1629 C CG   . PRO   A 1 133 ? 50.430 14.529  15.890 1.00 26.47 ? 113 PRO   A CG   1 
ATOM   1630 C CD   . PRO   A 1 133 ? 49.775 13.226  15.493 1.00 20.10 ? 113 PRO   A CD   1 
ATOM   1631 H HA   . PRO   A 1 133 ? 52.528 13.497  14.261 1.00 22.72 ? 113 PRO   A HA   1 
ATOM   1632 H HB2  . PRO   A 1 133 ? 52.036 13.883  17.000 1.00 24.94 ? 113 PRO   A HB2  1 
ATOM   1633 H HB3  . PRO   A 1 133 ? 52.434 14.986  15.927 1.00 24.94 ? 113 PRO   A HB3  1 
ATOM   1634 H HG2  . PRO   A 1 133 ? 50.046 14.870  16.714 1.00 31.78 ? 113 PRO   A HG2  1 
ATOM   1635 H HG3  . PRO   A 1 133 ? 50.339 15.189  15.184 1.00 31.78 ? 113 PRO   A HG3  1 
ATOM   1636 H HD2  . PRO   A 1 133 ? 49.451 12.749  16.273 1.00 24.14 ? 113 PRO   A HD2  1 
ATOM   1637 H HD3  . PRO   A 1 133 ? 49.047 13.379  14.871 1.00 24.14 ? 113 PRO   A HD3  1 
ATOM   1638 N N    . GLY   A 1 134 ? 54.370 12.081  15.012 1.00 20.24 ? 114 GLY   A N    1 
ATOM   1639 C CA   . GLY   A 1 134 ? 55.426 11.175  15.401 1.00 24.39 ? 114 GLY   A CA   1 
ATOM   1640 C C    . GLY   A 1 134 ? 55.585 9.993   14.478 1.00 28.21 ? 114 GLY   A C    1 
ATOM   1641 O O    . GLY   A 1 134 ? 56.620 9.317   14.525 1.00 26.14 ? 114 GLY   A O    1 
ATOM   1642 H H    . GLY   A 1 134 ? 54.576 12.589  14.350 1.00 24.30 ? 114 GLY   A H    1 
ATOM   1643 H HA2  . GLY   A 1 134 ? 56.267 11.660  15.415 1.00 29.28 ? 114 GLY   A HA2  1 
ATOM   1644 H HA3  . GLY   A 1 134 ? 55.241 10.838  16.291 1.00 29.28 ? 114 GLY   A HA3  1 
ATOM   1645 N N    . TYR   A 1 135 ? 54.587 9.724   13.647 1.00 20.85 ? 115 TYR   A N    1 
ATOM   1646 C CA   . TYR   A 1 135 ? 54.617 8.625   12.699 1.00 20.79 ? 115 TYR   A CA   1 
ATOM   1647 C C    . TYR   A 1 135 ? 54.611 9.180   11.282 1.00 17.54 ? 115 TYR   A C    1 
ATOM   1648 O O    . TYR   A 1 135 ? 54.105 10.280  11.046 1.00 21.07 ? 115 TYR   A O    1 
ATOM   1649 C CB   . TYR   A 1 135 ? 53.404 7.699   12.884 1.00 20.43 ? 115 TYR   A CB   1 
ATOM   1650 C CG   . TYR   A 1 135 ? 53.252 7.082   14.261 1.00 19.93 ? 115 TYR   A CG   1 
ATOM   1651 C CD1  . TYR   A 1 135 ? 53.865 5.880   14.578 1.00 19.91 ? 115 TYR   A CD1  1 
ATOM   1652 C CD2  . TYR   A 1 135 ? 52.461 7.687   15.241 1.00 19.74 ? 115 TYR   A CD2  1 
ATOM   1653 C CE1  . TYR   A 1 135 ? 53.718 5.303   15.825 1.00 21.58 ? 115 TYR   A CE1  1 
ATOM   1654 C CE2  . TYR   A 1 135 ? 52.309 7.116   16.486 1.00 20.82 ? 115 TYR   A CE2  1 
ATOM   1655 C CZ   . TYR   A 1 135 ? 52.940 5.918   16.773 1.00 23.57 ? 115 TYR   A CZ   1 
ATOM   1656 O OH   . TYR   A 1 135 ? 52.793 5.344   18.011 1.00 24.09 ? 115 TYR   A OH   1 
ATOM   1657 H H    . TYR   A 1 135 ? 53.859 10.180  13.614 1.00 25.03 ? 115 TYR   A H    1 
ATOM   1658 H HA   . TYR   A 1 135 ? 55.419 8.095   12.831 1.00 24.96 ? 115 TYR   A HA   1 
ATOM   1659 H HB2  . TYR   A 1 135 ? 52.600 8.212   12.708 1.00 24.53 ? 115 TYR   A HB2  1 
ATOM   1660 H HB3  . TYR   A 1 135 ? 53.478 6.970   12.248 1.00 24.53 ? 115 TYR   A HB3  1 
ATOM   1661 H HD1  . TYR   A 1 135 ? 54.387 5.453   13.938 1.00 23.91 ? 115 TYR   A HD1  1 
ATOM   1662 H HD2  . TYR   A 1 135 ? 52.030 8.489   15.050 1.00 23.70 ? 115 TYR   A HD2  1 
ATOM   1663 H HE1  . TYR   A 1 135 ? 54.145 4.500   16.020 1.00 25.91 ? 115 TYR   A HE1  1 
ATOM   1664 H HE2  . TYR   A 1 135 ? 51.785 7.534   17.130 1.00 25.00 ? 115 TYR   A HE2  1 
ATOM   1665 H HH   . TYR   A 1 135 ? 53.241 4.635   18.054 1.00 28.92 ? 115 TYR   A HH   1 
ATOM   1666 N N    . PRO   A 1 136 ? 55.167 8.454   10.313 1.00 21.79 ? 116 PRO   A N    1 
ATOM   1667 C CA   . PRO   A 1 136 ? 54.991 8.867   8.920  1.00 22.05 ? 116 PRO   A CA   1 
ATOM   1668 C C    . PRO   A 1 136 ? 53.523 8.794   8.546  1.00 21.53 ? 116 PRO   A C    1 
ATOM   1669 O O    . PRO   A 1 136 ? 52.758 7.999   9.096  1.00 21.45 ? 116 PRO   A O    1 
ATOM   1670 C CB   . PRO   A 1 136 ? 55.831 7.855   8.122  1.00 24.00 ? 116 PRO   A CB   1 
ATOM   1671 C CG   . PRO   A 1 136 ? 56.719 7.193   9.128  1.00 30.80 ? 116 PRO   A CG   1 
ATOM   1672 C CD   . PRO   A 1 136 ? 55.959 7.221   10.425 1.00 28.23 ? 116 PRO   A CD   1 
ATOM   1673 H HA   . PRO   A 1 136 ? 55.344 9.756   8.758  1.00 26.47 ? 116 PRO   A HA   1 
ATOM   1674 H HB2  . PRO   A 1 136 ? 55.247 7.207   7.697  1.00 28.81 ? 116 PRO   A HB2  1 
ATOM   1675 H HB3  . PRO   A 1 136 ? 56.355 8.320   7.451  1.00 28.81 ? 116 PRO   A HB3  1 
ATOM   1676 H HG2  . PRO   A 1 136 ? 56.899 6.279   8.855  1.00 36.97 ? 116 PRO   A HG2  1 
ATOM   1677 H HG3  . PRO   A 1 136 ? 57.550 7.686   9.206  1.00 36.97 ? 116 PRO   A HG3  1 
ATOM   1678 H HD2  . PRO   A 1 136 ? 55.383 6.445   10.506 1.00 33.89 ? 116 PRO   A HD2  1 
ATOM   1679 H HD3  . PRO   A 1 136 ? 56.565 7.266   11.181 1.00 33.89 ? 116 PRO   A HD3  1 
ATOM   1680 N N    . ARG   A 1 137 ? 53.125 9.665   7.630  1.00 20.65 ? 117 ARG   A N    1 
ATOM   1681 C CA   . ARG   A 1 137 ? 51.790 9.583   7.056  1.00 20.73 ? 117 ARG   A CA   1 
ATOM   1682 C C    . ARG   A 1 137 ? 51.591 8.193   6.475  1.00 19.90 ? 117 ARG   A C    1 
ATOM   1683 O O    . ARG   A 1 137 ? 52.463 7.664   5.778  1.00 23.19 ? 117 ARG   A O    1 
ATOM   1684 C CB   . ARG   A 1 137 ? 51.603 10.654  5.982  1.00 25.57 ? 117 ARG   A CB   1 
ATOM   1685 C CG   . ARG   A 1 137 ? 50.193 10.744  5.427  1.00 30.47 ? 117 ARG   A CG   1 
ATOM   1686 C CD   . ARG   A 1 137 ? 50.097 11.866  4.401  1.00 37.59 ? 117 ARG   A CD   1 
ATOM   1687 N NE   . ARG   A 1 137 ? 48.735 12.066  3.921  1.00 34.55 ? 117 ARG   A NE   1 
ATOM   1688 C CZ   . ARG   A 1 137 ? 47.962 13.089  4.262  1.00 28.26 ? 117 ARG   A CZ   1 
ATOM   1689 N NH1  . ARG   A 1 137 ? 48.393 14.046  5.070  1.00 33.52 ? 117 ARG   A NH1  1 
ATOM   1690 N NH2  . ARG   A 1 137 ? 46.727 13.158  3.777  1.00 35.79 ? 117 ARG   A NH2  1 
ATOM   1691 H H    . ARG   A 1 137 ? 53.606 10.309  7.325  1.00 24.79 ? 117 ARG   A H    1 
ATOM   1692 H HA   . ARG   A 1 137 ? 51.119 9.744   7.738  1.00 24.89 ? 117 ARG   A HA   1 
ATOM   1693 H HB2  . ARG   A 1 137 ? 51.824 11.518  6.364  1.00 30.70 ? 117 ARG   A HB2  1 
ATOM   1694 H HB3  . ARG   A 1 137 ? 52.198 10.457  5.241  1.00 30.70 ? 117 ARG   A HB3  1 
ATOM   1695 H HG2  . ARG   A 1 137 ? 49.960 9.908   4.994  1.00 36.58 ? 117 ARG   A HG2  1 
ATOM   1696 H HG3  . ARG   A 1 137 ? 49.571 10.930  6.148  1.00 36.58 ? 117 ARG   A HG3  1 
ATOM   1697 H HD2  . ARG   A 1 137 ? 50.398 12.694  4.807  1.00 45.12 ? 117 ARG   A HD2  1 
ATOM   1698 H HD3  . ARG   A 1 137 ? 50.656 11.648  3.639  1.00 45.12 ? 117 ARG   A HD3  1 
ATOM   1699 H HE   . ARG   A 1 137 ? 48.410 11.482  3.379  1.00 41.47 ? 117 ARG   A HE   1 
ATOM   1700 H HH11 . ARG   A 1 137 ? 47.874 14.700  5.278  1.00 40.23 ? 117 ARG   A HH11 1 
ATOM   1701 H HH12 . ARG   A 1 137 ? 49.192 14.014  5.387  1.00 40.23 ? 117 ARG   A HH12 1 
ATOM   1702 H HH21 . ARG   A 1 137 ? 46.438 12.544  3.249  1.00 42.96 ? 117 ARG   A HH21 1 
ATOM   1703 H HH22 . ARG   A 1 137 ? 46.217 13.816  3.991  1.00 42.96 ? 117 ARG   A HH22 1 
ATOM   1704 N N    . GLY   A 1 138 ? 50.448 7.583   6.793  1.00 21.99 ? 118 GLY   A N    1 
ATOM   1705 C CA   . GLY   A 1 138 ? 50.169 6.233   6.368  1.00 21.02 ? 118 GLY   A CA   1 
ATOM   1706 C C    . GLY   A 1 138 ? 48.838 6.155   5.645  1.00 14.55 ? 118 GLY   A C    1 
ATOM   1707 O O    . GLY   A 1 138 ? 48.043 7.096   5.647  1.00 17.45 ? 118 GLY   A O    1 
ATOM   1708 H H    . GLY   A 1 138 ? 49.819 7.941   7.258  1.00 26.40 ? 118 GLY   A H    1 
ATOM   1709 H HA2  . GLY   A 1 138 ? 50.867 5.928   5.768  1.00 25.24 ? 118 GLY   A HA2  1 
ATOM   1710 H HA3  . GLY   A 1 138 ? 50.138 5.647   7.140  1.00 25.24 ? 118 GLY   A HA3  1 
ATOM   1711 N N    . GLN   A 1 139 ? 48.623 5.011   5.008  1.00 19.47 ? 119 GLN   A N    1 
ATOM   1712 C CA   . GLN   A 1 139 ? 47.351 4.662   4.396  1.00 19.49 ? 119 GLN   A CA   1 
ATOM   1713 C C    . GLN   A 1 139 ? 46.732 3.584   5.274  1.00 16.79 ? 119 GLN   A C    1 
ATOM   1714 O O    . GLN   A 1 139 ? 47.277 2.487   5.398  1.00 21.41 ? 119 GLN   A O    1 
ATOM   1715 C CB   . GLN   A 1 139 ? 47.536 4.175   2.965  1.00 21.17 ? 119 GLN   A CB   1 
ATOM   1716 C CG   . GLN   A 1 139 ? 47.327 5.274   1.942  1.00 38.81 ? 119 GLN   A CG   1 
ATOM   1717 C CD   . GLN   A 1 139 ? 45.925 5.847   1.988  1.00 42.23 ? 119 GLN   A CD   1 
ATOM   1718 O OE1  . GLN   A 1 139 ? 45.738 7.055   2.098  1.00 36.07 ? 119 GLN   A OE1  1 
ATOM   1719 N NE2  . GLN   A 1 139 ? 44.928 4.972   1.898  1.00 48.62 ? 119 GLN   A NE2  1 
ATOM   1720 H H    . GLN   A 1 139 ? 49.222 4.400   4.914  1.00 23.38 ? 119 GLN   A H    1 
ATOM   1721 H HA   . GLN   A 1 139 ? 46.767 5.435   4.365  1.00 23.40 ? 119 GLN   A HA   1 
ATOM   1722 H HB2  . GLN   A 1 139 ? 48.439 3.835   2.861  1.00 25.42 ? 119 GLN   A HB2  1 
ATOM   1723 H HB3  . GLN   A 1 139 ? 46.894 3.470   2.785  1.00 25.42 ? 119 GLN   A HB3  1 
ATOM   1724 H HG2  . GLN   A 1 139 ? 47.953 5.994   2.118  1.00 46.58 ? 119 GLN   A HG2  1 
ATOM   1725 H HG3  . GLN   A 1 139 ? 47.477 4.914   1.054  1.00 46.58 ? 119 GLN   A HG3  1 
ATOM   1726 H HE21 . GLN   A 1 139 ? 45.098 4.133   1.819  1.00 58.36 ? 119 GLN   A HE21 1 
ATOM   1727 H HE22 . GLN   A 1 139 ? 44.113 5.246   1.919  1.00 58.36 ? 119 GLN   A HE22 1 
ATOM   1728 N N    . TYR   A 1 140 ? 45.607 3.910   5.892  1.00 16.03 ? 120 TYR   A N    1 
ATOM   1729 C CA   . TYR   A 1 140 ? 44.960 3.067   6.885  1.00 14.12 ? 120 TYR   A CA   1 
ATOM   1730 C C    . TYR   A 1 140 ? 43.687 2.496   6.282  1.00 14.76 ? 120 TYR   A C    1 
ATOM   1731 O O    . TYR   A 1 140 ? 42.851 3.241   5.773  1.00 17.02 ? 120 TYR   A O    1 
ATOM   1732 C CB   . TYR   A 1 140 ? 44.676 3.897   8.140  1.00 15.49 ? 120 TYR   A CB   1 
ATOM   1733 C CG   . TYR   A 1 140 ? 43.925 3.216   9.250  1.00 13.57 ? 120 TYR   A CG   1 
ATOM   1734 C CD1  . TYR   A 1 140 ? 44.144 1.889   9.566  1.00 14.05 ? 120 TYR   A CD1  1 
ATOM   1735 C CD2  . TYR   A 1 140 ? 43.025 3.940   10.018 1.00 14.60 ? 120 TYR   A CD2  1 
ATOM   1736 C CE1  . TYR   A 1 140 ? 43.467 1.285   10.604 1.00 12.92 ? 120 TYR   A CE1  1 
ATOM   1737 C CE2  . TYR   A 1 140 ? 42.344 3.351   11.052 1.00 15.98 ? 120 TYR   A CE2  1 
ATOM   1738 C CZ   . TYR   A 1 140 ? 42.571 2.023   11.344 1.00 15.03 ? 120 TYR   A CZ   1 
ATOM   1739 O OH   . TYR   A 1 140 ? 41.887 1.439   12.377 1.00 17.07 ? 120 TYR   A OH   1 
ATOM   1740 H H    . TYR   A 1 140 ? 45.183 4.644   5.747  1.00 19.25 ? 120 TYR   A H    1 
ATOM   1741 H HA   . TYR   A 1 140 ? 45.519 2.316   7.138  1.00 16.95 ? 120 TYR   A HA   1 
ATOM   1742 H HB2  . TYR   A 1 140 ? 45.526 4.184   8.509  1.00 18.60 ? 120 TYR   A HB2  1 
ATOM   1743 H HB3  . TYR   A 1 140 ? 44.151 4.669   7.876  1.00 18.60 ? 120 TYR   A HB3  1 
ATOM   1744 H HD1  . TYR   A 1 140 ? 44.757 1.395   9.071  1.00 16.88 ? 120 TYR   A HD1  1 
ATOM   1745 H HD2  . TYR   A 1 140 ? 42.882 4.839   9.829  1.00 17.54 ? 120 TYR   A HD2  1 
ATOM   1746 H HE1  . TYR   A 1 140 ? 43.615 0.388   10.803 1.00 15.52 ? 120 TYR   A HE1  1 
ATOM   1747 H HE2  . TYR   A 1 140 ? 41.733 3.843   11.552 1.00 19.18 ? 120 TYR   A HE2  1 
ATOM   1748 H HH   . TYR   A 1 140 ? 41.204 1.892   12.562 1.00 20.50 ? 120 TYR   A HH   1 
ATOM   1749 N N    . ARG   A 1 141 ? 43.569 1.180   6.313  1.00 14.76 ? 121 ARG   A N    1 
ATOM   1750 C CA   . ARG   A 1 141 ? 42.364 0.486   5.884  1.00 13.57 ? 121 ARG   A CA   1 
ATOM   1751 C C    . ARG   A 1 141 ? 42.012 -0.506  6.976  1.00 15.64 ? 121 ARG   A C    1 
ATOM   1752 O O    . ARG   A 1 141 ? 42.891 -1.164  7.547  1.00 17.56 ? 121 ARG   A O    1 
ATOM   1753 C CB   . ARG   A 1 141 ? 42.571 -0.227  4.544  1.00 19.65 ? 121 ARG   A CB   1 
ATOM   1754 C CG   . ARG   A 1 141 ? 43.055 0.710   3.447  1.00 37.45 ? 121 ARG   A CG   1 
ATOM   1755 C CD   . ARG   A 1 141 ? 43.056 0.068   2.061  1.00 50.74 ? 121 ARG   A CD   1 
ATOM   1756 N NE   . ARG   A 1 141 ? 44.072 -0.966  1.903  1.00 58.60 ? 121 ARG   A NE   1 
ATOM   1757 C CZ   . ARG   A 1 141 ? 44.540 -1.381  0.732  1.00 70.75 ? 121 ARG   A CZ   1 
ATOM   1758 N NH1  . ARG   A 1 141 ? 44.155 -0.823  -0.406 1.00 49.03 ? 121 ARG   A NH1  1 
ATOM   1759 N NH2  . ARG   A 1 141 ? 45.417 -2.381  0.700  1.00 75.48 ? 121 ARG   A NH2  1 
ATOM   1760 H H    . ARG   A 1 141 ? 44.190 0.652   6.586  1.00 17.72 ? 121 ARG   A H    1 
ATOM   1761 H HA   . ARG   A 1 141 ? 41.627 1.104   5.758  1.00 16.30 ? 121 ARG   A HA   1 
ATOM   1762 H HB2  . ARG   A 1 141 ? 43.234 -0.926  4.657  1.00 23.59 ? 121 ARG   A HB2  1 
ATOM   1763 H HB3  . ARG   A 1 141 ? 41.728 -0.614  4.258  1.00 23.59 ? 121 ARG   A HB3  1 
ATOM   1764 H HG2  . ARG   A 1 141 ? 42.473 1.485   3.416  1.00 44.95 ? 121 ARG   A HG2  1 
ATOM   1765 H HG3  . ARG   A 1 141 ? 43.963 0.986   3.647  1.00 44.95 ? 121 ARG   A HG3  1 
ATOM   1766 H HD2  . ARG   A 1 141 ? 42.190 -0.340  1.904  1.00 60.90 ? 121 ARG   A HD2  1 
ATOM   1767 H HD3  . ARG   A 1 141 ? 43.224 0.754   1.397  1.00 60.90 ? 121 ARG   A HD3  1 
ATOM   1768 H HE   . ARG   A 1 141 ? 44.389 -1.330  2.615  1.00 70.34 ? 121 ARG   A HE   1 
ATOM   1769 H HH11 . ARG   A 1 141 ? 43.589 -0.176  -0.398 1.00 58.85 ? 121 ARG   A HH11 1 
ATOM   1770 H HH12 . ARG   A 1 141 ? 44.470 -1.108  -1.154 1.00 58.85 ? 121 ARG   A HH12 1 
ATOM   1771 H HH21 . ARG   A 1 141 ? 45.675 -2.750  1.433  1.00 90.58 ? 121 ARG   A HH21 1 
ATOM   1772 H HH22 . ARG   A 1 141 ? 45.726 -2.658  -0.053 1.00 90.58 ? 121 ARG   A HH22 1 
ATOM   1773 N N    . ASN   A 1 142 ? 40.730 -0.582  7.310  1.00 15.11 ? 122 ASN   A N    1 
ATOM   1774 C CA   . ASN   A 1 142 ? 40.329 -1.532  8.330  1.00 12.83 ? 122 ASN   A CA   1 
ATOM   1775 C C    . ASN   A 1 142 ? 38.905 -1.983  8.064  1.00 12.81 ? 122 ASN   A C    1 
ATOM   1776 O O    . ASN   A 1 142 ? 38.173 -1.413  7.251  1.00 13.74 ? 122 ASN   A O    1 
ATOM   1777 C CB   . ASN   A 1 142 ? 40.454 -0.939  9.742  1.00 15.05 ? 122 ASN   A CB   1 
ATOM   1778 C CG   . ASN   A 1 142 ? 40.926 -1.963  10.794 1.00 14.30 ? 122 ASN   A CG   1 
ATOM   1779 O OD1  . ASN   A 1 142 ? 40.719 -3.169  10.660 1.00 18.42 ? 122 ASN   A OD1  1 
ATOM   1780 N ND2  . ASN   A 1 142 ? 41.555 -1.465  11.848 1.00 15.19 ? 122 ASN   A ND2  1 
ATOM   1781 H H    . ASN   A 1 142 ? 40.097 -0.109  6.970  1.00 18.14 ? 122 ASN   A H    1 
ATOM   1782 H HA   . ASN   A 1 142 ? 40.909 -2.307  8.272  1.00 15.40 ? 122 ASN   A HA   1 
ATOM   1783 H HB2  . ASN   A 1 142 ? 41.099 -0.214  9.722  1.00 18.07 ? 122 ASN   A HB2  1 
ATOM   1784 H HB3  . ASN   A 1 142 ? 39.588 -0.604  10.020 1.00 18.07 ? 122 ASN   A HB3  1 
ATOM   1785 H HD21 . ASN   A 1 142 ? 41.840 -1.989  12.467 1.00 18.24 ? 122 ASN   A HD21 1 
ATOM   1786 H HD22 . ASN   A 1 142 ? 41.678 -0.616  11.914 1.00 18.24 ? 122 ASN   A HD22 1 
ATOM   1787 N N    A HIS   A 1 143 ? 38.565 -3.081  8.698  0.49 15.01 ? 123 HIS   A N    1 
ATOM   1788 N N    C HIS   A 1 143 ? 38.523 -3.020  8.802  0.51 14.89 ? 123 HIS   A N    1 
ATOM   1789 C CA   A HIS   A 1 143 ? 37.213 -3.596  8.717  0.49 14.08 ? 123 HIS   A CA   1 
ATOM   1790 C CA   C HIS   A 1 143 ? 37.222 -3.677  8.745  0.51 14.24 ? 123 HIS   A CA   1 
ATOM   1791 C C    A HIS   A 1 143 ? 36.591 -3.195  10.044 0.49 12.50 ? 123 HIS   A C    1 
ATOM   1792 C C    C HIS   A 1 143 ? 36.514 -3.381  10.063 0.51 12.50 ? 123 HIS   A C    1 
ATOM   1793 O O    A HIS   A 1 143 ? 37.237 -3.266  11.090 0.49 13.87 ? 123 HIS   A O    1 
ATOM   1794 O O    C HIS   A 1 143 ? 37.034 -3.712  11.132 0.51 16.43 ? 123 HIS   A O    1 
ATOM   1795 C CB   A HIS   A 1 143 ? 37.225 -5.109  8.550  0.49 15.18 ? 123 HIS   A CB   1 
ATOM   1796 C CB   C HIS   A 1 143 ? 37.427 -5.179  8.542  0.51 15.88 ? 123 HIS   A CB   1 
ATOM   1797 C CG   A HIS   A 1 143 ? 35.870 -5.726  8.588  0.49 17.09 ? 123 HIS   A CG   1 
ATOM   1798 C CG   C HIS   A 1 143 ? 36.170 -5.970  8.365  0.51 19.05 ? 123 HIS   A CG   1 
ATOM   1799 N ND1  A HIS   A 1 143 ? 35.297 -6.166  9.759  0.49 17.67 ? 123 HIS   A ND1  1 
ATOM   1800 N ND1  C HIS   A 1 143 ? 36.194 -7.301  8.012  0.51 21.70 ? 123 HIS   A ND1  1 
ATOM   1801 C CD2  A HIS   A 1 143 ? 34.977 -5.983  7.605  0.49 23.18 ? 123 HIS   A CD2  1 
ATOM   1802 C CD2  C HIS   A 1 143 ? 34.865 -5.635  8.492  0.51 15.30 ? 123 HIS   A CD2  1 
ATOM   1803 C CE1  A HIS   A 1 143 ? 34.104 -6.668  9.496  0.49 21.59 ? 123 HIS   A CE1  1 
ATOM   1804 C CE1  C HIS   A 1 143 ? 34.956 -7.753  7.930  0.51 19.20 ? 123 HIS   A CE1  1 
ATOM   1805 N NE2  A HIS   A 1 143 ? 33.887 -6.571  8.196  0.49 17.63 ? 123 HIS   A NE2  1 
ATOM   1806 N NE2  C HIS   A 1 143 ? 34.131 -6.762  8.218  0.51 17.77 ? 123 HIS   A NE2  1 
ATOM   1807 H H    A HIS   A 1 143 ? 39.119 -3.566  9.142  0.49 18.03 ? 123 HIS   A H    1 
ATOM   1808 H H    C HIS   A 1 143 ? 39.037 -3.387  9.386  0.51 17.88 ? 123 HIS   A H    1 
ATOM   1809 H HA   A HIS   A 1 143 ? 36.677 -3.234  7.995  0.49 16.91 ? 123 HIS   A HA   1 
ATOM   1810 H HA   C HIS   A 1 143 ? 36.672 -3.343  8.020  0.51 17.10 ? 123 HIS   A HA   1 
ATOM   1811 H HB2  A HIS   A 1 143 ? 37.625 -5.325  7.693  0.49 18.23 ? 123 HIS   A HB2  1 
ATOM   1812 H HB2  C HIS   A 1 143 ? 37.968 -5.310  7.747  0.51 19.07 ? 123 HIS   A HB2  1 
ATOM   1813 H HB3  A HIS   A 1 143 ? 37.749 -5.498  9.268  0.49 18.23 ? 123 HIS   A HB3  1 
ATOM   1814 H HB3  C HIS   A 1 143 ? 37.888 -5.534  9.318  0.51 19.07 ? 123 HIS   A HB3  1 
ATOM   1815 H HD2  A HIS   A 1 143 ? 35.082 -5.796  6.700  0.49 27.83 ? 123 HIS   A HD2  1 
ATOM   1816 H HD2  C HIS   A 1 143 ? 34.529 -4.799  8.722  0.51 18.37 ? 123 HIS   A HD2  1 
ATOM   1817 H HE1  A HIS   A 1 143 ? 33.516 -7.028  10.119 0.49 25.92 ? 123 HIS   A HE1  1 
ATOM   1818 H HE1  C HIS   A 1 143 ? 34.707 -8.622  7.708  0.51 23.05 ? 123 HIS   A HE1  1 
ATOM   1819 H HE2  A HIS   A 1 143 ? 33.178 -6.833  7.787  0.49 21.17 ? 123 HIS   A HE2  1 
ATOM   1820 H HE2  C HIS   A 1 143 ? 33.272 -6.815  8.231  0.51 21.33 ? 123 HIS   A HE2  1 
ATOM   1821 N N    . PHE   A 1 144 ? 35.357 -2.727  9.990  1.00 11.89 ? 124 PHE   A N    1 
ATOM   1822 C CA   . PHE   A 1 144 ? 34.701 -2.180  11.164 1.00 11.29 ? 124 PHE   A CA   1 
ATOM   1823 C C    . PHE   A 1 144 ? 33.337 -2.803  11.406 1.00 11.96 ? 124 PHE   A C    1 
ATOM   1824 O O    . PHE   A 1 144 ? 32.584 -3.073  10.469 1.00 13.32 ? 124 PHE   A O    1 
ATOM   1825 C CB   . PHE   A 1 144 ? 34.490 -0.680  11.037 1.00 12.43 ? 124 PHE   A CB   1 
ATOM   1826 C CG   . PHE   A 1 144 ? 35.735 0.111   11.022 1.00 12.17 ? 124 PHE   A CG   1 
ATOM   1827 C CD1  . PHE   A 1 144 ? 36.463 0.254   9.868  1.00 11.87 ? 124 PHE   A CD1  1 
ATOM   1828 C CD2  . PHE   A 1 144 ? 36.167 0.734   12.188 1.00 16.18 ? 124 PHE   A CD2  1 
ATOM   1829 C CE1  . PHE   A 1 144 ? 37.624 1.008   9.861  1.00 13.70 ? 124 PHE   A CE1  1 
ATOM   1830 C CE2  . PHE   A 1 144 ? 37.319 1.469   12.188 1.00 17.79 ? 124 PHE   A CE2  1 
ATOM   1831 C CZ   . PHE   A 1 144 ? 38.044 1.607   11.029 1.00 15.14 ? 124 PHE   A CZ   1 
ATOM   1832 H H    A PHE   A 1 144 ? 34.875 -2.715  9.278  0.49 14.28 ? 124 PHE   A H    1 
ATOM   1833 H H    C PHE   A 1 144 ? 34.930 -2.587  9.257  0.51 14.28 ? 124 PHE   A H    1 
ATOM   1834 H HA   . PHE   A 1 144 ? 35.271 -2.388  11.921 1.00 13.56 ? 124 PHE   A HA   1 
ATOM   1835 H HB2  . PHE   A 1 144 ? 34.019 -0.503  10.208 1.00 14.93 ? 124 PHE   A HB2  1 
ATOM   1836 H HB3  . PHE   A 1 144 ? 33.959 -0.378  11.791 1.00 14.93 ? 124 PHE   A HB3  1 
ATOM   1837 H HD1  . PHE   A 1 144 ? 36.175 -0.157  9.086  1.00 14.26 ? 124 PHE   A HD1  1 
ATOM   1838 H HD2  . PHE   A 1 144 ? 35.670 0.650   12.969 1.00 19.43 ? 124 PHE   A HD2  1 
ATOM   1839 H HE1  . PHE   A 1 144 ? 38.114 1.109   9.077  1.00 16.45 ? 124 PHE   A HE1  1 
ATOM   1840 H HE2  . PHE   A 1 144 ? 37.611 1.876   12.971 1.00 21.37 ? 124 PHE   A HE2  1 
ATOM   1841 H HZ   . PHE   A 1 144 ? 38.826 2.109   11.033 1.00 18.18 ? 124 PHE   A HZ   1 
ATOM   1842 N N    . LEU   A 1 145 ? 33.017 -2.974  12.684 1.00 13.56 ? 125 LEU   A N    1 
ATOM   1843 C CA   . LEU   A 1 145 ? 31.649 -3.140  13.143 1.00 10.07 ? 125 LEU   A CA   1 
ATOM   1844 C C    . LEU   A 1 145 ? 31.318 -1.938  14.008 1.00 13.17 ? 125 LEU   A C    1 
ATOM   1845 O O    . LEU   A 1 145 ? 32.115 -1.541  14.867 1.00 14.19 ? 125 LEU   A O    1 
ATOM   1846 C CB   . LEU   A 1 145 ? 31.459 -4.421  13.948 1.00 12.57 ? 125 LEU   A CB   1 
ATOM   1847 C CG   . LEU   A 1 145 ? 32.051 -5.626  13.186 1.00 18.70 ? 125 LEU   A CG   1 
ATOM   1848 C CD1  . LEU   A 1 145 ? 32.019 -6.864  14.050 1.00 25.76 ? 125 LEU   A CD1  1 
ATOM   1849 C CD2  . LEU   A 1 145 ? 31.324 -5.876  11.890 1.00 19.07 ? 125 LEU   A CD2  1 
ATOM   1850 H H    . LEU   A 1 145 ? 33.595 -2.997  13.321 1.00 16.29 ? 125 LEU   A H    1 
ATOM   1851 H HA   . LEU   A 1 145 ? 31.050 -3.189  12.382 1.00 12.10 ? 125 LEU   A HA   1 
ATOM   1852 H HB2  . LEU   A 1 145 ? 31.913 -4.339  14.801 1.00 15.10 ? 125 LEU   A HB2  1 
ATOM   1853 H HB3  . LEU   A 1 145 ? 30.512 -4.578  14.090 1.00 15.10 ? 125 LEU   A HB3  1 
ATOM   1854 H HG   . LEU   A 1 145 ? 32.974 -5.423  12.967 1.00 22.45 ? 125 LEU   A HG   1 
ATOM   1855 H HD11 . LEU   A 1 145 ? 32.155 -7.644  13.490 1.00 30.92 ? 125 LEU   A HD11 1 
ATOM   1856 H HD12 . LEU   A 1 145 ? 32.726 -6.805  14.712 1.00 30.92 ? 125 LEU   A HD12 1 
ATOM   1857 H HD13 . LEU   A 1 145 ? 31.157 -6.919  14.491 1.00 30.92 ? 125 LEU   A HD13 1 
ATOM   1858 H HD21 . LEU   A 1 145 ? 31.682 -6.676  11.476 1.00 22.90 ? 125 LEU   A HD21 1 
ATOM   1859 H HD22 . LEU   A 1 145 ? 30.379 -5.995  12.077 1.00 22.90 ? 125 LEU   A HD22 1 
ATOM   1860 H HD23 . LEU   A 1 145 ? 31.452 -5.114  11.304 1.00 22.90 ? 125 LEU   A HD23 1 
ATOM   1861 N N    . HIS   A 1 146 ? 30.172 -1.334  13.753 1.00 12.95 ? 126 HIS   A N    1 
ATOM   1862 C CA   . HIS   A 1 146 ? 29.684 -0.220  14.542 1.00 12.54 ? 126 HIS   A CA   1 
ATOM   1863 C C    . HIS   A 1 146 ? 28.401 -0.633  15.245 1.00 11.41 ? 126 HIS   A C    1 
ATOM   1864 O O    . HIS   A 1 146 ? 27.509 -1.226  14.631 1.00 12.56 ? 126 HIS   A O    1 
ATOM   1865 C CB   . HIS   A 1 146 ? 29.357 1.011   13.704 1.00 13.02 ? 126 HIS   A CB   1 
ATOM   1866 C CG   . HIS   A 1 146 ? 30.542 1.709   13.118 1.00 15.42 ? 126 HIS   A CG   1 
ATOM   1867 N ND1  . HIS   A 1 146 ? 31.106 2.828   13.696 1.00 19.53 ? 126 HIS   A ND1  1 
ATOM   1868 C CD2  . HIS   A 1 146 ? 31.225 1.486   11.972 1.00 17.56 ? 126 HIS   A CD2  1 
ATOM   1869 C CE1  . HIS   A 1 146 ? 32.097 3.255   12.932 1.00 20.72 ? 126 HIS   A CE1  1 
ATOM   1870 N NE2  . HIS   A 1 146 ? 32.201 2.445   11.892 1.00 16.43 ? 126 HIS   A NE2  1 
ATOM   1871 H H    . HIS   A 1 146 ? 29.646 -1.557  13.110 1.00 15.55 ? 126 HIS   A H    1 
ATOM   1872 H HA   . HIS   A 1 146 ? 30.376 0.014   15.180 1.00 15.06 ? 126 HIS   A HA   1 
ATOM   1873 H HB2  . HIS   A 1 146 ? 28.787 0.739   12.968 1.00 15.63 ? 126 HIS   A HB2  1 
ATOM   1874 H HB3  . HIS   A 1 146 ? 28.891 1.650   14.265 1.00 15.63 ? 126 HIS   A HB3  1 
ATOM   1875 H HD2  . HIS   A 1 146 ? 31.063 0.810   11.355 1.00 21.09 ? 126 HIS   A HD2  1 
ATOM   1876 H HE1  . HIS   A 1 146 ? 32.630 3.999   13.099 1.00 24.87 ? 126 HIS   A HE1  1 
ATOM   1877 H HE2  . HIS   A 1 146 ? 32.787 2.510   11.266 1.00 19.73 ? 126 HIS   A HE2  1 
ATOM   1878 N N    . SER   A 1 147 ? 28.302 -0.272  16.515 1.00 11.77 ? 127 SER   A N    1 
ATOM   1879 C CA   . SER   A 1 147 ? 27.093 -0.438  17.306 1.00 11.83 ? 127 SER   A CA   1 
ATOM   1880 C C    . SER   A 1 147 ? 26.488 0.942   17.530 1.00 12.73 ? 127 SER   A C    1 
ATOM   1881 O O    . SER   A 1 147 ? 27.194 1.866   17.931 1.00 11.66 ? 127 SER   A O    1 
ATOM   1882 C CB   . SER   A 1 147 ? 27.427 -1.099  18.637 1.00 13.36 ? 127 SER   A CB   1 
ATOM   1883 O OG   . SER   A 1 147 ? 26.295 -1.161  19.487 1.00 12.66 ? 127 SER   A OG   1 
ATOM   1884 H H    . SER   A 1 147 ? 28.947 0.086   16.957 1.00 14.13 ? 127 SER   A H    1 
ATOM   1885 H HA   . SER   A 1 147 ? 26.446 -0.994  16.846 1.00 14.20 ? 127 SER   A HA   1 
ATOM   1886 H HB2  . SER   A 1 147 ? 27.741 -2.001  18.468 1.00 16.04 ? 127 SER   A HB2  1 
ATOM   1887 H HB3  . SER   A 1 147 ? 28.121 -0.583  19.077 1.00 16.04 ? 127 SER   A HB3  1 
ATOM   1888 H HG   . SER   A 1 147 ? 26.331 -0.546  20.058 1.00 15.21 ? 127 SER   A HG   1 
ATOM   1889 N N    . PHE   A 1 148 ? 25.200 1.090   17.231 1.00 12.33 ? 128 PHE   A N    1 
ATOM   1890 C CA   . PHE   A 1 148 ? 24.472 2.335   17.462 1.00 11.29 ? 128 PHE   A CA   1 
ATOM   1891 C C    . PHE   A 1 148 ? 23.275 2.041   18.343 1.00 13.28 ? 128 PHE   A C    1 
ATOM   1892 O O    . PHE   A 1 148 ? 22.372 1.308   17.932 1.00 14.14 ? 128 PHE   A O    1 
ATOM   1893 C CB   . PHE   A 1 148 ? 23.968 2.972   16.170 1.00 12.46 ? 128 PHE   A CB   1 
ATOM   1894 C CG   . PHE   A 1 148 ? 25.043 3.468   15.263 1.00 10.57 ? 128 PHE   A CG   1 
ATOM   1895 C CD1  . PHE   A 1 148 ? 25.504 4.761   15.353 1.00 14.03 ? 128 PHE   A CD1  1 
ATOM   1896 C CD2  . PHE   A 1 148 ? 25.577 2.632   14.298 1.00 12.34 ? 128 PHE   A CD2  1 
ATOM   1897 C CE1  . PHE   A 1 148 ? 26.481 5.219   14.515 1.00 16.11 ? 128 PHE   A CE1  1 
ATOM   1898 C CE2  . PHE   A 1 148 ? 26.553 3.085   13.457 1.00 12.28 ? 128 PHE   A CE2  1 
ATOM   1899 C CZ   . PHE   A 1 148 ? 27.011 4.375   13.558 1.00 15.69 ? 128 PHE   A CZ   1 
ATOM   1900 H H    . PHE   A 1 148 ? 24.716 0.469   16.885 1.00 14.81 ? 128 PHE   A H    1 
ATOM   1901 H HA   . PHE   A 1 148 ? 25.077 2.952   17.903 1.00 13.57 ? 128 PHE   A HA   1 
ATOM   1902 H HB2  . PHE   A 1 148 ? 23.454 2.311   15.680 1.00 14.97 ? 128 PHE   A HB2  1 
ATOM   1903 H HB3  . PHE   A 1 148 ? 23.405 3.728   16.398 1.00 14.97 ? 128 PHE   A HB3  1 
ATOM   1904 H HD1  . PHE   A 1 148 ? 25.145 5.332   15.994 1.00 16.85 ? 128 PHE   A HD1  1 
ATOM   1905 H HD2  . PHE   A 1 148 ? 25.269 1.758   14.221 1.00 14.82 ? 128 PHE   A HD2  1 
ATOM   1906 H HE1  . PHE   A 1 148 ? 26.788 6.094   14.588 1.00 19.34 ? 128 PHE   A HE1  1 
ATOM   1907 H HE2  . PHE   A 1 148 ? 26.910 2.517   12.814 1.00 14.75 ? 128 PHE   A HE2  1 
ATOM   1908 H HZ   . PHE   A 1 148 ? 27.677 4.680   12.984 1.00 18.84 ? 128 PHE   A HZ   1 
ATOM   1909 N N    . ARG   A 1 149 ? 23.250 2.634   19.529 1.00 14.13 ? 129 ARG   A N    1 
ATOM   1910 C CA   . ARG   A 1 149 ? 22.091 2.569   20.405 1.00 13.75 ? 129 ARG   A CA   1 
ATOM   1911 C C    . ARG   A 1 149 ? 21.482 3.957   20.519 1.00 13.93 ? 129 ARG   A C    1 
ATOM   1912 O O    . ARG   A 1 149 ? 22.203 4.945   20.716 1.00 14.91 ? 129 ARG   A O    1 
ATOM   1913 C CB   . ARG   A 1 149 ? 22.471 2.020   21.774 1.00 15.17 ? 129 ARG   A CB   1 
ATOM   1914 C CG   . ARG   A 1 149 ? 22.999 0.599   21.699 1.00 14.18 ? 129 ARG   A CG   1 
ATOM   1915 C CD   . ARG   A 1 149 ? 23.228 0.051   23.078 1.00 19.07 ? 129 ARG   A CD   1 
ATOM   1916 N NE   . ARG   A 1 149 ? 21.953 -0.237  23.717 1.00 20.02 ? 129 ARG   A NE   1 
ATOM   1917 C CZ   . ARG   A 1 149 ? 21.821 -0.787  24.917 1.00 24.34 ? 129 ARG   A CZ   1 
ATOM   1918 N NH1  . ARG   A 1 149 ? 22.872 -1.088  25.658 1.00 25.47 ? 129 ARG   A NH1  1 
ATOM   1919 N NH2  . ARG   A 1 149 ? 20.601 -1.045  25.381 1.00 27.39 ? 129 ARG   A NH2  1 
ATOM   1920 H H    . ARG   A 1 149 ? 23.905 3.087   19.853 1.00 16.97 ? 129 ARG   A H    1 
ATOM   1921 H HA   . ARG   A 1 149 ? 21.420 1.977   20.031 1.00 16.51 ? 129 ARG   A HA   1 
ATOM   1922 H HB2  . ARG   A 1 149 ? 23.164 2.579   22.159 1.00 18.22 ? 129 ARG   A HB2  1 
ATOM   1923 H HB3  . ARG   A 1 149 ? 21.688 2.022   22.346 1.00 18.22 ? 129 ARG   A HB3  1 
ATOM   1924 H HG2  . ARG   A 1 149 ? 22.352 0.036   21.246 1.00 17.03 ? 129 ARG   A HG2  1 
ATOM   1925 H HG3  . ARG   A 1 149 ? 23.841 0.590   21.218 1.00 17.03 ? 129 ARG   A HG3  1 
ATOM   1926 H HD2  . ARG   A 1 149 ? 23.741 -0.771  23.022 1.00 22.89 ? 129 ARG   A HD2  1 
ATOM   1927 H HD3  . ARG   A 1 149 ? 23.705 0.704   23.614 1.00 22.89 ? 129 ARG   A HD3  1 
ATOM   1928 H HE   . ARG   A 1 149 ? 21.235 -0.037  23.288 1.00 24.04 ? 129 ARG   A HE   1 
ATOM   1929 H HH11 . ARG   A 1 149 ? 23.665 -0.928  25.364 1.00 30.57 ? 129 ARG   A HH11 1 
ATOM   1930 H HH12 . ARG   A 1 149 ? 22.764 -1.444  26.433 1.00 30.57 ? 129 ARG   A HH12 1 
ATOM   1931 H HH21 . ARG   A 1 149 ? 19.910 -0.856  24.904 1.00 32.88 ? 129 ARG   A HH21 1 
ATOM   1932 H HH22 . ARG   A 1 149 ? 20.502 -1.402  26.158 1.00 32.88 ? 129 ARG   A HH22 1 
ATOM   1933 N N    . PHE   A 1 150 ? 20.161 4.014   20.399 1.00 15.10 ? 130 PHE   A N    1 
ATOM   1934 C CA   . PHE   A 1 150 ? 19.406 5.249   20.300 1.00 14.40 ? 130 PHE   A CA   1 
ATOM   1935 C C    . PHE   A 1 150 ? 18.574 5.493   21.548 1.00 17.17 ? 130 PHE   A C    1 
ATOM   1936 O O    . PHE   A 1 150 ? 18.126 4.559   22.215 1.00 19.22 ? 130 PHE   A O    1 
ATOM   1937 C CB   . PHE   A 1 150 ? 18.487 5.216   19.081 1.00 15.80 ? 130 PHE   A CB   1 
ATOM   1938 C CG   . PHE   A 1 150 ? 19.211 5.413   17.794 1.00 15.98 ? 130 PHE   A CG   1 
ATOM   1939 C CD1  . PHE   A 1 150 ? 19.884 4.364   17.191 1.00 15.88 ? 130 PHE   A CD1  1 
ATOM   1940 C CD2  . PHE   A 1 150 ? 19.241 6.653   17.197 1.00 12.93 ? 130 PHE   A CD2  1 
ATOM   1941 C CE1  . PHE   A 1 150 ? 20.562 4.565   16.015 1.00 15.13 ? 130 PHE   A CE1  1 
ATOM   1942 C CE2  . PHE   A 1 150 ? 19.915 6.857   16.026 1.00 18.13 ? 130 PHE   A CE2  1 
ATOM   1943 C CZ   . PHE   A 1 150 ? 20.586 5.808   15.434 1.00 16.18 ? 130 PHE   A CZ   1 
ATOM   1944 H H    . PHE   A 1 150 ? 19.660 3.316   20.373 1.00 18.13 ? 130 PHE   A H    1 
ATOM   1945 H HA   . PHE   A 1 150 ? 20.029 5.988   20.215 1.00 17.29 ? 130 PHE   A HA   1 
ATOM   1946 H HB2  . PHE   A 1 150 ? 18.044 4.354   19.045 1.00 18.97 ? 130 PHE   A HB2  1 
ATOM   1947 H HB3  . PHE   A 1 150 ? 17.830 5.924   19.165 1.00 18.97 ? 130 PHE   A HB3  1 
ATOM   1948 H HD1  . PHE   A 1 150 ? 19.877 3.522   17.585 1.00 19.06 ? 130 PHE   A HD1  1 
ATOM   1949 H HD2  . PHE   A 1 150 ? 18.795 7.364   17.598 1.00 15.53 ? 130 PHE   A HD2  1 
ATOM   1950 H HE1  . PHE   A 1 150 ? 21.006 3.855   15.610 1.00 18.17 ? 130 PHE   A HE1  1 
ATOM   1951 H HE2  . PHE   A 1 150 ? 19.921 7.698   15.630 1.00 21.76 ? 130 PHE   A HE2  1 
ATOM   1952 H HZ   . PHE   A 1 150 ? 21.056 5.943   14.643 1.00 19.43 ? 130 PHE   A HZ   1 
ATOM   1953 N N    . GLU   A 1 151 ? 18.374 6.778   21.840 1.00 17.46 ? 131 GLU   A N    1 
ATOM   1954 C CA   . GLU   A 1 151 ? 17.441 7.226   22.865 1.00 18.94 ? 131 GLU   A CA   1 
ATOM   1955 C C    . GLU   A 1 151 ? 16.720 8.443   22.314 1.00 17.68 ? 131 GLU   A C    1 
ATOM   1956 O O    . GLU   A 1 151 ? 17.361 9.432   21.949 1.00 18.82 ? 131 GLU   A O    1 
ATOM   1957 C CB   . GLU   A 1 151 ? 18.170 7.556   24.154 1.00 19.85 ? 131 GLU   A CB   1 
ATOM   1958 C CG   . GLU   A 1 151 ? 17.291 7.895   25.334 1.00 25.33 ? 131 GLU   A CG   1 
ATOM   1959 C CD   . GLU   A 1 151 ? 18.143 8.314   26.510 1.00 29.27 ? 131 GLU   A CD   1 
ATOM   1960 O OE1  . GLU   A 1 151 ? 18.568 9.488   26.533 1.00 40.60 ? 131 GLU   A OE1  1 
ATOM   1961 O OE2  . GLU   A 1 151 ? 18.428 7.466   27.371 1.00 53.29 ? 131 GLU   A OE2  1 
ATOM   1962 H H    . GLU   A 1 151 ? 18.779 7.425   21.445 1.00 20.96 ? 131 GLU   A H    1 
ATOM   1963 H HA   . GLU   A 1 151 ? 16.789 6.537   23.063 1.00 22.74 ? 131 GLU   A HA   1 
ATOM   1964 H HB2  . GLU   A 1 151 ? 18.707 6.788   24.406 1.00 23.84 ? 131 GLU   A HB2  1 
ATOM   1965 H HB3  . GLU   A 1 151 ? 18.743 8.322   23.993 1.00 23.84 ? 131 GLU   A HB3  1 
ATOM   1966 H HG2  . GLU   A 1 151 ? 16.699 8.627   25.101 1.00 30.41 ? 131 GLU   A HG2  1 
ATOM   1967 H HG3  . GLU   A 1 151 ? 16.771 7.116   25.588 1.00 30.41 ? 131 GLU   A HG3  1 
ATOM   1968 N N    . ASN   A 1 152 ? 15.391 8.354   22.235 1.00 19.45 ? 132 ASN   A N    1 
ATOM   1969 C CA   . ASN   A 1 152 ? 14.552 9.469   21.798 1.00 27.37 ? 132 ASN   A CA   1 
ATOM   1970 C C    . ASN   A 1 152 ? 15.077 10.098  20.509 1.00 23.95 ? 132 ASN   A C    1 
ATOM   1971 O O    . ASN   A 1 152 ? 15.184 11.317  20.378 1.00 25.88 ? 132 ASN   A O    1 
ATOM   1972 C CB   . ASN   A 1 152 ? 14.430 10.517  22.906 1.00 26.61 ? 132 ASN   A CB   1 
ATOM   1973 C CG   . ASN   A 1 152 ? 13.347 11.546  22.621 1.00 37.25 ? 132 ASN   A CG   1 
ATOM   1974 O OD1  . ASN   A 1 152 ? 12.493 11.350  21.756 1.00 37.98 ? 132 ASN   A OD1  1 
ATOM   1975 N ND2  . ASN   A 1 152 ? 13.375 12.648  23.361 1.00 38.04 ? 132 ASN   A ND2  1 
ATOM   1976 H H    . ASN   A 1 152 ? 14.945 7.646   22.432 1.00 23.36 ? 132 ASN   A H    1 
ATOM   1977 H HA   . ASN   A 1 152 ? 13.667 9.121   21.606 1.00 32.85 ? 132 ASN   A HA   1 
ATOM   1978 H HB2  . ASN   A 1 152 ? 14.210 10.072  23.740 1.00 31.94 ? 132 ASN   A HB2  1 
ATOM   1979 H HB3  . ASN   A 1 152 ? 15.275 10.985  22.992 1.00 31.94 ? 132 ASN   A HB3  1 
ATOM   1980 H HD21 . ASN   A 1 152 ? 12.785 13.262  23.240 1.00 45.66 ? 132 ASN   A HD21 1 
ATOM   1981 H HD22 . ASN   A 1 152 ? 13.983 12.748  23.960 1.00 45.66 ? 132 ASN   A HD22 1 
ATOM   1982 N N    . GLY   A 1 153 ? 15.401 9.246   19.537 1.00 18.94 ? 133 GLY   A N    1 
ATOM   1983 C CA   . GLY   A 1 153 ? 15.690 9.703   18.198 1.00 18.84 ? 133 GLY   A CA   1 
ATOM   1984 C C    . GLY   A 1 153 ? 17.122 10.108  17.923 1.00 16.20 ? 133 GLY   A C    1 
ATOM   1985 O O    . GLY   A 1 153 ? 17.421 10.525  16.800 1.00 16.78 ? 133 GLY   A O    1 
ATOM   1986 H H    . GLY   A 1 153 ? 15.459 8.394   19.638 1.00 22.74 ? 133 GLY   A H    1 
ATOM   1987 H HA2  . GLY   A 1 153 ? 15.467 8.991   17.578 1.00 22.62 ? 133 GLY   A HA2  1 
ATOM   1988 H HA3  . GLY   A 1 153 ? 15.130 10.473  18.010 1.00 22.62 ? 133 GLY   A HA3  1 
ATOM   1989 N N    . LEU   A 1 154 ? 18.017 10.000  18.898 1.00 16.89 ? 134 LEU   A N    1 
ATOM   1990 C CA   . LEU   A 1 154 ? 19.413 10.344  18.691 1.00 15.11 ? 134 LEU   A CA   1 
ATOM   1991 C C    . LEU   A 1 154 ? 20.294 9.245   19.266 1.00 15.72 ? 134 LEU   A C    1 
ATOM   1992 O O    . LEU   A 1 154 ? 19.852 8.369   20.016 1.00 14.90 ? 134 LEU   A O    1 
ATOM   1993 C CB   . LEU   A 1 154 ? 19.764 11.686  19.325 1.00 16.25 ? 134 LEU   A CB   1 
ATOM   1994 C CG   . LEU   A 1 154 ? 19.115 12.904  18.682 1.00 14.60 ? 134 LEU   A CG   1 
ATOM   1995 C CD1  . LEU   A 1 154 ? 19.311 14.085  19.632 1.00 19.64 ? 134 LEU   A CD1  1 
ATOM   1996 C CD2  . LEU   A 1 154 ? 19.687 13.201  17.321 1.00 19.11 ? 134 LEU   A CD2  1 
ATOM   1997 H H    . LEU   A 1 154 ? 17.836 9.727   19.693 1.00 20.29 ? 134 LEU   A H    1 
ATOM   1998 H HA   . LEU   A 1 154 ? 19.583 10.408  17.738 1.00 18.15 ? 134 LEU   A HA   1 
ATOM   1999 H HB2  . LEU   A 1 154 ? 19.485 11.666  20.254 1.00 19.51 ? 134 LEU   A HB2  1 
ATOM   2000 H HB3  . LEU   A 1 154 ? 20.725 11.806  19.270 1.00 19.51 ? 134 LEU   A HB3  1 
ATOM   2001 H HG   . LEU   A 1 154 ? 18.170 12.741  18.536 1.00 17.53 ? 134 LEU   A HG   1 
ATOM   2002 H HD11 . LEU   A 1 154 ? 18.810 14.846  19.298 1.00 23.58 ? 134 LEU   A HD11 1 
ATOM   2003 H HD12 . LEU   A 1 154 ? 18.989 13.838  20.513 1.00 23.58 ? 134 LEU   A HD12 1 
ATOM   2004 H HD13 . LEU   A 1 154 ? 20.255 14.303  19.674 1.00 23.58 ? 134 LEU   A HD13 1 
ATOM   2005 H HD21 . LEU   A 1 154 ? 19.455 14.109  17.073 1.00 22.94 ? 134 LEU   A HD21 1 
ATOM   2006 H HD22 . LEU   A 1 154 ? 20.652 13.103  17.356 1.00 22.94 ? 134 LEU   A HD22 1 
ATOM   2007 H HD23 . LEU   A 1 154 ? 19.314 12.577  16.679 1.00 22.94 ? 134 LEU   A HD23 1 
ATOM   2008 N N    . ILE   A 1 155 ? 21.569 9.294   18.905 1.00 14.95 ? 135 ILE   A N    1 
ATOM   2009 C CA   . ILE   A 1 155 ? 22.499 8.244   19.307 1.00 14.36 ? 135 ILE   A CA   1 
ATOM   2010 C C    . ILE   A 1 155 ? 22.877 8.453   20.768 1.00 14.40 ? 135 ILE   A C    1 
ATOM   2011 O O    . ILE   A 1 155 ? 23.418 9.497   21.139 1.00 14.58 ? 135 ILE   A O    1 
ATOM   2012 C CB   . ILE   A 1 155 ? 23.748 8.228   18.416 1.00 12.45 ? 135 ILE   A CB   1 
ATOM   2013 C CG1  . ILE   A 1 155 ? 23.374 7.981   16.962 1.00 13.16 ? 135 ILE   A CG1  1 
ATOM   2014 C CG2  . ILE   A 1 155 ? 24.697 7.136   18.897 1.00 13.47 ? 135 ILE   A CG2  1 
ATOM   2015 C CD1  . ILE   A 1 155 ? 24.500 8.306   16.030 1.00 13.10 ? 135 ILE   A CD1  1 
ATOM   2016 H H    . ILE   A 1 155 ? 21.919 9.919   18.430 1.00 17.95 ? 135 ILE   A H    1 
ATOM   2017 H HA   . ILE   A 1 155 ? 22.055 7.386   19.225 1.00 17.24 ? 135 ILE   A HA   1 
ATOM   2018 H HB   . ILE   A 1 155 ? 24.182 9.093   18.475 1.00 14.95 ? 135 ILE   A HB   1 
ATOM   2019 H HG12 . ILE   A 1 155 ? 23.144 7.045   16.847 1.00 15.81 ? 135 ILE   A HG12 1 
ATOM   2020 H HG13 . ILE   A 1 155 ? 22.616 8.539   16.729 1.00 15.81 ? 135 ILE   A HG13 1 
ATOM   2021 H HG21 . ILE   A 1 155 ? 25.384 6.996   18.226 1.00 16.18 ? 135 ILE   A HG21 1 
ATOM   2022 H HG22 . ILE   A 1 155 ? 25.103 7.416   19.732 1.00 16.18 ? 135 ILE   A HG22 1 
ATOM   2023 H HG23 . ILE   A 1 155 ? 24.194 6.318   19.032 1.00 16.18 ? 135 ILE   A HG23 1 
ATOM   2024 H HD11 . ILE   A 1 155 ? 24.183 8.233   15.116 1.00 15.74 ? 135 ILE   A HD11 1 
ATOM   2025 H HD12 . ILE   A 1 155 ? 24.803 9.211   16.204 1.00 15.74 ? 135 ILE   A HD12 1 
ATOM   2026 H HD13 . ILE   A 1 155 ? 25.225 7.679   16.180 1.00 15.74 ? 135 ILE   A HD13 1 
ATOM   2027 N N    . LYS   A 1 156 ? 22.587 7.454   21.595 1.00 14.60 ? 136 LYS   A N    1 
ATOM   2028 C CA   . LYS   A 1 156 ? 23.023 7.416   22.980 1.00 13.23 ? 136 LYS   A CA   1 
ATOM   2029 C C    . LYS   A 1 156 ? 24.399 6.796   23.136 1.00 14.29 ? 136 LYS   A C    1 
ATOM   2030 O O    . LYS   A 1 156 ? 25.162 7.208   24.011 1.00 15.38 ? 136 LYS   A O    1 
ATOM   2031 C CB   . LYS   A 1 156 ? 22.007 6.628   23.814 1.00 21.54 ? 136 LYS   A CB   1 
ATOM   2032 C CG   . LYS   A 1 156 ? 22.328 6.526   25.298 1.00 26.08 ? 136 LYS   A CG   1 
ATOM   2033 C CD   . LYS   A 1 156 ? 21.947 7.805   26.025 1.00 40.87 ? 136 LYS   A CD   1 
ATOM   2034 C CE   . LYS   A 1 156 ? 21.914 7.613   27.531 1.00 39.63 ? 136 LYS   A CE   1 
ATOM   2035 N NZ   . LYS   A 1 156 ? 21.026 8.624   28.172 1.00 51.45 ? 136 LYS   A NZ   1 
ATOM   2036 H H    . LYS   A 1 156 ? 22.124 6.765   21.368 1.00 17.53 ? 136 LYS   A H    1 
ATOM   2037 H HA   . LYS   A 1 156 ? 23.064 8.320   23.329 1.00 15.89 ? 136 LYS   A HA   1 
ATOM   2038 H HB2  . LYS   A 1 156 ? 21.143 7.062   23.733 1.00 25.86 ? 136 LYS   A HB2  1 
ATOM   2039 H HB3  . LYS   A 1 156 ? 21.960 5.725   23.464 1.00 25.86 ? 136 LYS   A HB3  1 
ATOM   2040 H HG2  . LYS   A 1 156 ? 21.828 5.791   25.687 1.00 31.31 ? 136 LYS   A HG2  1 
ATOM   2041 H HG3  . LYS   A 1 156 ? 23.279 6.378   25.414 1.00 31.31 ? 136 LYS   A HG3  1 
ATOM   2042 H HD2  . LYS   A 1 156 ? 22.598 8.495   25.821 1.00 49.05 ? 136 LYS   A HD2  1 
ATOM   2043 H HD3  . LYS   A 1 156 ? 21.065 8.087   25.736 1.00 49.05 ? 136 LYS   A HD3  1 
ATOM   2044 H HE2  . LYS   A 1 156 ? 21.574 6.729   27.738 1.00 47.56 ? 136 LYS   A HE2  1 
ATOM   2045 H HE3  . LYS   A 1 156 ? 22.809 7.717   27.891 1.00 47.56 ? 136 LYS   A HE3  1 
ATOM   2046 H HZ1  . LYS   A 1 156 ? 21.216 8.690   29.039 1.00 61.75 ? 136 LYS   A HZ1  1 
ATOM   2047 H HZ2  . LYS   A 1 156 ? 21.144 9.419   27.789 1.00 61.75 ? 136 LYS   A HZ2  1 
ATOM   2048 H HZ3  . LYS   A 1 156 ? 20.174 8.383   28.080 1.00 61.75 ? 136 LYS   A HZ3  1 
ATOM   2049 N N    . GLU   A 1 157 ? 24.718 5.808   22.306 1.00 15.00 ? 137 GLU   A N    1 
ATOM   2050 C CA   . GLU   A 1 157 ? 26.001 5.123   22.402 1.00 12.78 ? 137 GLU   A CA   1 
ATOM   2051 C C    . GLU   A 1 157 ? 26.395 4.619   21.023 1.00 11.27 ? 137 GLU   A C    1 
ATOM   2052 O O    . GLU   A 1 157 ? 25.677 3.818   20.430 1.00 12.77 ? 137 GLU   A O    1 
ATOM   2053 C CB   . GLU   A 1 157 ? 25.934 3.960   23.389 1.00 15.31 ? 137 GLU   A CB   1 
ATOM   2054 C CG   . GLU   A 1 157 ? 27.280 3.285   23.610 1.00 17.52 ? 137 GLU   A CG   1 
ATOM   2055 C CD   . GLU   A 1 157 ? 27.142 1.951   24.306 1.00 20.71 ? 137 GLU   A CD   1 
ATOM   2056 O OE1  . GLU   A 1 157 ? 26.583 1.014   23.698 1.00 18.33 ? 137 GLU   A OE1  1 
ATOM   2057 O OE2  . GLU   A 1 157 ? 27.583 1.852   25.475 1.00 23.59 ? 137 GLU   A OE2  1 
ATOM   2058 H H    . GLU   A 1 157 ? 24.209 5.517   21.678 1.00 18.01 ? 137 GLU   A H    1 
ATOM   2059 H HA   . GLU   A 1 157 ? 26.672 5.753   22.706 1.00 15.35 ? 137 GLU   A HA   1 
ATOM   2060 H HB2  . GLU   A 1 157 ? 25.622 4.291   24.245 1.00 18.38 ? 137 GLU   A HB2  1 
ATOM   2061 H HB3  . GLU   A 1 157 ? 25.318 3.293   23.047 1.00 18.38 ? 137 GLU   A HB3  1 
ATOM   2062 H HG2  . GLU   A 1 157 ? 27.706 3.136   22.751 1.00 21.04 ? 137 GLU   A HG2  1 
ATOM   2063 H HG3  . GLU   A 1 157 ? 27.836 3.858   24.160 1.00 21.04 ? 137 GLU   A HG3  1 
ATOM   2064 N N    . GLN   A 1 158 ? 27.529 5.091   20.533 1.00 12.74 ? 138 GLN   A N    1 
ATOM   2065 C CA   . GLN   A 1 158 ? 28.171 4.588   19.329 1.00 12.67 ? 138 GLN   A CA   1 
ATOM   2066 C C    . GLN   A 1 158 ? 29.470 3.923   19.742 1.00 13.42 ? 138 GLN   A C    1 
ATOM   2067 O O    . GLN   A 1 158 ? 30.219 4.468   20.551 1.00 14.48 ? 138 GLN   A O    1 
ATOM   2068 C CB   . GLN   A 1 158 ? 28.423 5.724   18.342 1.00 12.43 ? 138 GLN   A CB   1 
ATOM   2069 C CG   . GLN   A 1 158 ? 29.150 5.308   17.066 1.00 15.50 ? 138 GLN   A CG   1 
ATOM   2070 C CD   . GLN   A 1 158 ? 30.660 5.359   17.207 1.00 16.58 ? 138 GLN   A CD   1 
ATOM   2071 O OE1  . GLN   A 1 158 ? 31.194 6.156   18.001 1.00 22.32 ? 138 GLN   A OE1  1 
ATOM   2072 N NE2  . GLN   A 1 158 ? 31.353 4.540   16.448 1.00 20.06 ? 138 GLN   A NE2  1 
ATOM   2073 H H    . GLN   A 1 158 ? 27.967 5.735   20.898 1.00 15.31 ? 138 GLN   A H    1 
ATOM   2074 H HA   . GLN   A 1 158 ? 27.616 3.935   18.874 1.00 15.21 ? 138 GLN   A HA   1 
ATOM   2075 H HB2  . GLN   A 1 158 ? 27.569 6.102   18.081 1.00 14.93 ? 138 GLN   A HB2  1 
ATOM   2076 H HB3  . GLN   A 1 158 ? 28.965 6.399   18.780 1.00 14.93 ? 138 GLN   A HB3  1 
ATOM   2077 H HG2  . GLN   A 1 158 ? 28.900 4.398   16.842 1.00 18.61 ? 138 GLN   A HG2  1 
ATOM   2078 H HG3  . GLN   A 1 158 ? 28.896 5.909   16.348 1.00 18.61 ? 138 GLN   A HG3  1 
ATOM   2079 H HE21 . GLN   A 1 158 ? 30.948 4.010   15.906 1.00 24.08 ? 138 GLN   A HE21 1 
ATOM   2080 H HE22 . GLN   A 1 158 ? 32.212 4.534   16.495 1.00 24.08 ? 138 GLN   A HE22 1 
ATOM   2081 N N    . ARG   A 1 159 ? 29.722 2.731   19.208 1.00 11.58 ? 139 ARG   A N    1 
ATOM   2082 C CA   . ARG   A 1 159 ? 30.947 2.004   19.496 1.00 11.32 ? 139 ARG   A CA   1 
ATOM   2083 C C    . ARG   A 1 159 ? 31.498 1.456   18.194 1.00 11.77 ? 139 ARG   A C    1 
ATOM   2084 O O    . ARG   A 1 159 ? 30.763 0.867   17.399 1.00 12.92 ? 139 ARG   A O    1 
ATOM   2085 C CB   . ARG   A 1 159 ? 30.712 0.869   20.486 1.00 12.45 ? 139 ARG   A CB   1 
ATOM   2086 C CG   . ARG   A 1 159 ? 30.172 1.319   21.831 1.00 11.61 ? 139 ARG   A CG   1 
ATOM   2087 C CD   . ARG   A 1 159 ? 29.861 0.103   22.688 1.00 14.05 ? 139 ARG   A CD   1 
ATOM   2088 N NE   . ARG   A 1 159 ? 28.823 -0.711  22.070 1.00 14.06 ? 139 ARG   A NE   1 
ATOM   2089 C CZ   . ARG   A 1 159 ? 28.628 -1.997  22.311 1.00 12.17 ? 139 ARG   A CZ   1 
ATOM   2090 N NH1  . ARG   A 1 159 ? 29.387 -2.663  23.163 1.00 14.37 ? 139 ARG   A NH1  1 
ATOM   2091 N NH2  . ARG   A 1 159 ? 27.654 -2.634  21.670 1.00 11.71 ? 139 ARG   A NH2  1 
ATOM   2092 H H    . ARG   A 1 159 ? 29.191 2.321   18.670 1.00 13.91 ? 139 ARG   A H    1 
ATOM   2093 H HA   . ARG   A 1 159 ? 31.599 2.607   19.886 1.00 13.60 ? 139 ARG   A HA   1 
ATOM   2094 H HB2  . ARG   A 1 159 ? 30.069 0.251   20.103 1.00 14.95 ? 139 ARG   A HB2  1 
ATOM   2095 H HB3  . ARG   A 1 159 ? 31.554 0.415   20.645 1.00 14.95 ? 139 ARG   A HB3  1 
ATOM   2096 H HG2  . ARG   A 1 159 ? 30.834 1.862   22.286 1.00 13.94 ? 139 ARG   A HG2  1 
ATOM   2097 H HG3  . ARG   A 1 159 ? 29.356 1.829   21.704 1.00 13.94 ? 139 ARG   A HG3  1 
ATOM   2098 H HD2  . ARG   A 1 159 ? 30.660 -0.438  22.785 1.00 16.88 ? 139 ARG   A HD2  1 
ATOM   2099 H HD3  . ARG   A 1 159 ? 29.548 0.391   23.560 1.00 16.88 ? 139 ARG   A HD3  1 
ATOM   2100 H HE   . ARG   A 1 159 ? 28.299 -0.327  21.508 1.00 16.88 ? 139 ARG   A HE   1 
ATOM   2101 H HH11 . ARG   A 1 159 ? 30.026 -2.261  23.575 1.00 17.25 ? 139 ARG   A HH11 1 
ATOM   2102 H HH12 . ARG   A 1 159 ? 29.243 -3.499  23.305 1.00 17.25 ? 139 ARG   A HH12 1 
ATOM   2103 H HH21 . ARG   A 1 159 ? 27.160 -2.210  21.107 1.00 14.06 ? 139 ARG   A HH21 1 
ATOM   2104 H HH22 . ARG   A 1 159 ? 27.517 -3.470  21.817 1.00 14.06 ? 139 ARG   A HH22 1 
ATOM   2105 N N    . GLU   A 1 160 ? 32.800 1.649   18.005 1.00 13.93 ? 140 GLU   A N    1 
ATOM   2106 C CA   . GLU   A 1 160 ? 33.551 1.184   16.849 1.00 15.74 ? 140 GLU   A CA   1 
ATOM   2107 C C    . GLU   A 1 160 ? 34.387 -0.017  17.238 1.00 12.70 ? 140 GLU   A C    1 
ATOM   2108 O O    . GLU   A 1 160 ? 35.103 0.038   18.239 1.00 14.85 ? 140 GLU   A O    1 
ATOM   2109 C CB   . GLU   A 1 160 ? 34.490 2.303   16.406 1.00 22.24 ? 140 GLU   A CB   1 
ATOM   2110 C CG   . GLU   A 1 160 ? 34.699 2.556   14.985 1.00 45.77 ? 140 GLU   A CG   1 
ATOM   2111 C CD   . GLU   A 1 160 ? 35.176 3.973   14.864 1.00 24.08 ? 140 GLU   A CD   1 
ATOM   2112 O OE1  . GLU   A 1 160 ? 34.351 4.871   15.162 1.00 31.95 ? 140 GLU   A OE1  1 
ATOM   2113 O OE2  . GLU   A 1 160 ? 36.359 4.186   14.587 1.00 33.75 ? 140 GLU   A OE2  1 
ATOM   2114 H H    . GLU   A 1 160 ? 33.296 2.072   18.566 1.00 16.72 ? 140 GLU   A H    1 
ATOM   2115 H HA   . GLU   A 1 160 ? 32.949 0.927   16.133 1.00 18.90 ? 140 GLU   A HA   1 
ATOM   2116 H HB2  . GLU   A 1 160 ? 34.148 3.131   16.780 1.00 26.70 ? 140 GLU   A HB2  1 
ATOM   2117 H HB3  . GLU   A 1 160 ? 35.365 2.109   16.777 1.00 26.70 ? 140 GLU   A HB3  1 
ATOM   2118 H HG2  . GLU   A 1 160 ? 35.372 1.954   14.629 1.00 54.93 ? 140 GLU   A HG2  1 
ATOM   2119 H HG3  . GLU   A 1 160 ? 33.868 2.450   14.496 1.00 54.93 ? 140 GLU   A HG3  1 
ATOM   2120 N N    . PHE   A 1 161 ? 34.323 -1.080  16.436 1.00 11.62 ? 141 PHE   A N    1 
ATOM   2121 C CA   . PHE   A 1 161 ? 35.122 -2.278  16.649 1.00 12.38 ? 141 PHE   A CA   1 
ATOM   2122 C C    . PHE   A 1 161 ? 35.922 -2.553  15.385 1.00 13.98 ? 141 PHE   A C    1 
ATOM   2123 O O    . PHE   A 1 161 ? 35.345 -2.743  14.313 1.00 15.01 ? 141 PHE   A O    1 
ATOM   2124 C CB   . PHE   A 1 161 ? 34.249 -3.488  16.968 1.00 12.10 ? 141 PHE   A CB   1 
ATOM   2125 C CG   . PHE   A 1 161 ? 33.395 -3.333  18.201 1.00 12.23 ? 141 PHE   A CG   1 
ATOM   2126 C CD1  . PHE   A 1 161 ? 32.164 -2.698  18.125 1.00 14.09 ? 141 PHE   A CD1  1 
ATOM   2127 C CD2  . PHE   A 1 161 ? 33.817 -3.830  19.415 1.00 14.50 ? 141 PHE   A CD2  1 
ATOM   2128 C CE1  . PHE   A 1 161 ? 31.376 -2.553  19.267 1.00 16.42 ? 141 PHE   A CE1  1 
ATOM   2129 C CE2  . PHE   A 1 161 ? 33.042 -3.689  20.553 1.00 17.93 ? 141 PHE   A CE2  1 
ATOM   2130 C CZ   . PHE   A 1 161 ? 31.818 -3.054  20.470 1.00 16.58 ? 141 PHE   A CZ   1 
ATOM   2131 H H    A PHE   A 1 161 ? 33.811 -1.128  15.747 0.62 13.96 ? 141 PHE   A H    1 
ATOM   2132 H H    B PHE   A 1 161 ? 33.811 -1.128  15.747 0.38 13.96 ? 141 PHE   A H    1 
ATOM   2133 H HA   . PHE   A 1 161 ? 35.725 -2.125  17.393 1.00 14.87 ? 141 PHE   A HA   1 
ATOM   2134 H HB2  . PHE   A 1 161 ? 33.655 -3.647  16.218 1.00 14.53 ? 141 PHE   A HB2  1 
ATOM   2135 H HB3  . PHE   A 1 161 ? 34.824 -4.257  17.105 1.00 14.53 ? 141 PHE   A HB3  1 
ATOM   2136 H HD1  . PHE   A 1 161 ? 31.863 -2.367  17.309 1.00 16.92 ? 141 PHE   A HD1  1 
ATOM   2137 H HD2  . PHE   A 1 161 ? 34.636 -4.267  19.470 1.00 17.41 ? 141 PHE   A HD2  1 
ATOM   2138 H HE1  . PHE   A 1 161 ? 30.554 -2.120  19.216 1.00 19.72 ? 141 PHE   A HE1  1 
ATOM   2139 H HE2  . PHE   A 1 161 ? 33.344 -4.020  21.368 1.00 21.53 ? 141 PHE   A HE2  1 
ATOM   2140 H HZ   . PHE   A 1 161 ? 31.291 -2.964  21.230 1.00 19.91 ? 141 PHE   A HZ   1 
ATOM   2141 N N    . MET   A 1 162 ? 37.240 -2.601  15.507 1.00 12.40 ? 142 MET   A N    1 
ATOM   2142 C CA   . MET   A 1 162 ? 38.082 -2.922  14.362 1.00 11.57 ? 142 MET   A CA   1 
ATOM   2143 C C    . MET   A 1 162 ? 39.221 -3.817  14.820 1.00 13.66 ? 142 MET   A C    1 
ATOM   2144 O O    . MET   A 1 162 ? 39.254 -4.282  15.956 1.00 16.84 ? 142 MET   A O    1 
ATOM   2145 C CB   . MET   A 1 162 ? 38.584 -1.650  13.662 1.00 14.44 ? 142 MET   A CB   1 
ATOM   2146 C CG   . MET   A 1 162 ? 39.185 -0.576  14.545 1.00 14.36 ? 142 MET   A CG   1 
ATOM   2147 S SD   . MET   A 1 162 ? 40.672 -1.136  15.384 1.00 15.15 ? 142 MET   A SD   1 
ATOM   2148 C CE   . MET   A 1 162 ? 41.504 0.418   15.705 1.00 16.06 ? 142 MET   A CE   1 
ATOM   2149 H H    . MET   A 1 162 ? 37.669 -2.454  16.238 1.00 14.89 ? 142 MET   A H    1 
ATOM   2150 H HA   . MET   A 1 162 ? 37.553 -3.415  13.716 1.00 13.90 ? 142 MET   A HA   1 
ATOM   2151 H HB2  . MET   A 1 162 ? 39.269 -1.909  13.026 1.00 17.34 ? 142 MET   A HB2  1 
ATOM   2152 H HB3  . MET   A 1 162 ? 37.834 -1.247  13.197 1.00 17.34 ? 142 MET   A HB3  1 
ATOM   2153 H HG2  . MET   A 1 162 ? 39.417 0.191   13.998 1.00 17.24 ? 142 MET   A HG2  1 
ATOM   2154 H HG3  . MET   A 1 162 ? 38.536 -0.319  15.219 1.00 17.24 ? 142 MET   A HG3  1 
ATOM   2155 H HE1  . MET   A 1 162 ? 42.224 0.266   16.337 1.00 19.28 ? 142 MET   A HE1  1 
ATOM   2156 H HE2  . MET   A 1 162 ? 41.863 0.762   14.872 1.00 19.28 ? 142 MET   A HE2  1 
ATOM   2157 H HE3  . MET   A 1 162 ? 40.866 1.047   16.076 1.00 19.28 ? 142 MET   A HE3  1 
ATOM   2158 N N    . ASN   A 1 163 ? 40.147 -4.082  13.899 1.00 14.43 ? 143 ASN   A N    1 
ATOM   2159 C CA   . ASN   A 1 163 ? 41.323 -4.866  14.209 1.00 12.05 ? 143 ASN   A CA   1 
ATOM   2160 C C    . ASN   A 1 163 ? 42.487 -3.923  14.444 1.00 12.92 ? 143 ASN   A C    1 
ATOM   2161 O O    . ASN   A 1 163 ? 42.999 -3.342  13.479 1.00 13.93 ? 143 ASN   A O    1 
ATOM   2162 C CB   . ASN   A 1 163 ? 41.622 -5.818  13.059 1.00 14.28 ? 143 ASN   A CB   1 
ATOM   2163 C CG   . ASN   A 1 163 ? 42.791 -6.717  13.356 1.00 16.93 ? 143 ASN   A CG   1 
ATOM   2164 O OD1  . ASN   A 1 163 ? 43.510 -6.512  14.331 1.00 17.69 ? 143 ASN   A OD1  1 
ATOM   2165 N ND2  . ASN   A 1 163 ? 42.989 -7.718  12.516 1.00 17.29 ? 143 ASN   A ND2  1 
ATOM   2166 H H    . ASN   A 1 163 ? 40.111 -3.812  13.083 1.00 17.33 ? 143 ASN   A H    1 
ATOM   2167 H HA   . ASN   A 1 163 ? 41.181 -5.386  15.016 1.00 14.47 ? 143 ASN   A HA   1 
ATOM   2168 H HB2  . ASN   A 1 163 ? 40.845 -6.376  12.897 1.00 17.14 ? 143 ASN   A HB2  1 
ATOM   2169 H HB3  . ASN   A 1 163 ? 41.831 -5.302  12.265 1.00 17.14 ? 143 ASN   A HB3  1 
ATOM   2170 H HD21 . ASN   A 1 163 ? 43.644 -8.261  12.641 1.00 20.76 ? 143 ASN   A HD21 1 
ATOM   2171 H HD22 . ASN   A 1 163 ? 42.463 -7.826  11.844 1.00 20.76 ? 143 ASN   A HD22 1 
ATOM   2172 N N    . PRO   A 1 164 ? 42.925 -3.712  15.689 1.00 13.45 ? 144 PRO   A N    1 
ATOM   2173 C CA   . PRO   A 1 164 ? 44.016 -2.751  15.918 1.00 12.67 ? 144 PRO   A CA   1 
ATOM   2174 C C    . PRO   A 1 164 ? 45.288 -3.074  15.150 1.00 15.02 ? 144 PRO   A C    1 
ATOM   2175 O O    . PRO   A 1 164 ? 46.088 -2.169  14.893 1.00 15.08 ? 144 PRO   A O    1 
ATOM   2176 C CB   . PRO   A 1 164 ? 44.239 -2.824  17.438 1.00 16.15 ? 144 PRO   A CB   1 
ATOM   2177 C CG   . PRO   A 1 164 ? 42.906 -3.277  17.988 1.00 17.01 ? 144 PRO   A CG   1 
ATOM   2178 C CD   . PRO   A 1 164 ? 42.405 -4.260  16.952 1.00 15.35 ? 144 PRO   A CD   1 
ATOM   2179 H HA   . PRO   A 1 164 ? 43.724 -1.856  15.682 1.00 15.21 ? 144 PRO   A HA   1 
ATOM   2180 H HB2  . PRO   A 1 164 ? 44.937 -3.465  17.642 1.00 19.40 ? 144 PRO   A HB2  1 
ATOM   2181 H HB3  . PRO   A 1 164 ? 44.480 -1.950  17.782 1.00 19.40 ? 144 PRO   A HB3  1 
ATOM   2182 H HG2  . PRO   A 1 164 ? 43.027 -3.706  18.850 1.00 20.43 ? 144 PRO   A HG2  1 
ATOM   2183 H HG3  . PRO   A 1 164 ? 42.305 -2.521  18.076 1.00 20.43 ? 144 PRO   A HG3  1 
ATOM   2184 H HD2  . PRO   A 1 164 ? 42.761 -5.147  17.116 1.00 18.43 ? 144 PRO   A HD2  1 
ATOM   2185 H HD3  . PRO   A 1 164 ? 41.435 -4.288  16.943 1.00 18.43 ? 144 PRO   A HD3  1 
ATOM   2186 N N    . CYS   A 1 165 ? 45.487 -4.328  14.751 1.00 15.55 ? 145 CYS   A N    1 
ATOM   2187 C CA   . CYS   A 1 165 ? 46.703 -4.682  14.026 1.00 15.31 ? 145 CYS   A CA   1 
ATOM   2188 C C    . CYS   A 1 165 ? 46.796 -3.948  12.699 1.00 16.68 ? 145 CYS   A C    1 
ATOM   2189 O O    . CYS   A 1 165 ? 47.897 -3.635  12.243 1.00 16.35 ? 145 CYS   A O    1 
ATOM   2190 C CB   . CYS   A 1 165 ? 46.767 -6.184  13.789 1.00 16.71 ? 145 CYS   A CB   1 
ATOM   2191 S SG   . CYS   A 1 165 ? 46.860 -7.145  15.297 1.00 18.07 ? 145 CYS   A SG   1 
ATOM   2192 H H    . CYS   A 1 165 ? 44.944 -4.981  14.884 1.00 18.67 ? 145 CYS   A H    1 
ATOM   2193 H HA   . CYS   A 1 165 ? 47.464 -4.431  14.573 1.00 18.38 ? 145 CYS   A HA   1 
ATOM   2194 H HB2  . CYS   A 1 165 ? 45.969 -6.459  13.310 1.00 20.06 ? 145 CYS   A HB2  1 
ATOM   2195 H HB3  . CYS   A 1 165 ? 47.556 -6.383  13.260 1.00 20.06 ? 145 CYS   A HB3  1 
ATOM   2196 H HG   . CYS   A 1 165 ? 45.950 -7.927  15.319 1.00 21.70 ? 145 CYS   A HG   1 
ATOM   2197 N N    . GLU   A 1 166 ? 45.661 -3.687  12.046 1.00 14.44 ? 146 GLU   A N    1 
ATOM   2198 C CA   . GLU   A 1 166 ? 45.708 -2.957  10.779 1.00 15.47 ? 146 GLU   A CA   1 
ATOM   2199 C C    . GLU   A 1 166 ? 46.081 -1.499  10.999 1.00 15.46 ? 146 GLU   A C    1 
ATOM   2200 O O    . GLU   A 1 166 ? 46.683 -0.869  10.126 1.00 16.63 ? 146 GLU   A O    1 
ATOM   2201 C CB   . GLU   A 1 166 ? 44.374 -3.088  10.054 1.00 17.91 ? 146 GLU   A CB   1 
ATOM   2202 C CG   . GLU   A 1 166 ? 44.103 -4.513  9.598  1.00 19.33 ? 146 GLU   A CG   1 
ATOM   2203 C CD   . GLU   A 1 166 ? 45.291 -5.119  8.843  1.00 21.97 ? 146 GLU   A CD   1 
ATOM   2204 O OE1  . GLU   A 1 166 ? 45.518 -4.729  7.690  1.00 32.72 ? 146 GLU   A OE1  1 
ATOM   2205 O OE2  . GLU   A 1 166 ? 45.997 -5.960  9.430  1.00 36.56 ? 146 GLU   A OE2  1 
ATOM   2206 H H    . GLU   A 1 166 ? 44.874 -3.916  12.306 1.00 17.34 ? 146 GLU   A H    1 
ATOM   2207 H HA   . GLU   A 1 166 ? 46.385 -3.346  10.205 1.00 18.57 ? 146 GLU   A HA   1 
ATOM   2208 H HB2  . GLU   A 1 166 ? 43.660 -2.821  10.653 1.00 21.50 ? 146 GLU   A HB2  1 
ATOM   2209 H HB3  . GLU   A 1 166 ? 44.382 -2.517  9.270  1.00 21.50 ? 146 GLU   A HB3  1 
ATOM   2210 H HG2  . GLU   A 1 166 ? 43.924 -5.067  10.375 1.00 23.21 ? 146 GLU   A HG2  1 
ATOM   2211 H HG3  . GLU   A 1 166 ? 43.335 -4.516  9.005  1.00 23.21 ? 146 GLU   A HG3  1 
ATOM   2212 N N    . GLN   A 1 167 ? 45.742 -0.945  12.157 1.00 13.82 ? 147 GLN   A N    1 
ATOM   2213 C CA   . GLN   A 1 167 ? 46.209 0.393   12.478 1.00 13.87 ? 147 GLN   A CA   1 
ATOM   2214 C C    . GLN   A 1 167 ? 47.699 0.393   12.795 1.00 17.46 ? 147 GLN   A C    1 
ATOM   2215 O O    . GLN   A 1 167 ? 48.421 1.302   12.366 1.00 16.23 ? 147 GLN   A O    1 
ATOM   2216 C CB   . GLN   A 1 167 ? 45.394 0.963   13.630 1.00 15.31 ? 147 GLN   A CB   1 
ATOM   2217 C CG   . GLN   A 1 167 ? 45.625 2.432   13.816 1.00 16.26 ? 147 GLN   A CG   1 
ATOM   2218 C CD   . GLN   A 1 167 ? 44.731 3.020   14.868 1.00 19.57 ? 147 GLN   A CD   1 
ATOM   2219 O OE1  . GLN   A 1 167 ? 44.670 2.522   15.999 1.00 20.02 ? 147 GLN   A OE1  1 
ATOM   2220 N NE2  . GLN   A 1 167 ? 44.018 4.076   14.509 1.00 21.10 ? 147 GLN   A NE2  1 
ATOM   2221 H H    . GLN   A 1 167 ? 45.255 -1.315  12.761 1.00 16.60 ? 147 GLN   A H    1 
ATOM   2222 H HA   . GLN   A 1 167 ? 46.074 0.972   11.711 1.00 16.66 ? 147 GLN   A HA   1 
ATOM   2223 H HB2  . GLN   A 1 167 ? 44.451 0.826   13.450 1.00 18.38 ? 147 GLN   A HB2  1 
ATOM   2224 H HB3  . GLN   A 1 167 ? 45.645 0.511   14.450 1.00 18.38 ? 147 GLN   A HB3  1 
ATOM   2225 H HG2  . GLN   A 1 167 ? 46.545 2.577   14.087 1.00 19.52 ? 147 GLN   A HG2  1 
ATOM   2226 H HG3  . GLN   A 1 167 ? 45.450 2.890   12.980 1.00 19.52 ? 147 GLN   A HG3  1 
ATOM   2227 H HE21 . GLN   A 1 167 ? 44.083 4.387   13.709 1.00 25.34 ? 147 GLN   A HE21 1 
ATOM   2228 H HE22 . GLN   A 1 167 ? 43.490 4.450   15.074 1.00 25.34 ? 147 GLN   A HE22 1 
ATOM   2229 N N    . PHE   A 1 168 ? 48.186 -0.610  13.533 1.00 16.39 ? 148 PHE   A N    1 
ATOM   2230 C CA   . PHE   A 1 168 ? 49.632 -0.744  13.702 1.00 17.66 ? 148 PHE   A CA   1 
ATOM   2231 C C    . PHE   A 1 168 ? 50.320 -0.690  12.345 1.00 18.04 ? 148 PHE   A C    1 
ATOM   2232 O O    . PHE   A 1 168 ? 51.291 0.053   12.144 1.00 18.26 ? 148 PHE   A O    1 
ATOM   2233 C CB   . PHE   A 1 168 ? 50.032 -2.064  14.380 1.00 17.00 ? 148 PHE   A CB   1 
ATOM   2234 C CG   . PHE   A 1 168 ? 49.502 -2.272  15.765 1.00 17.66 ? 148 PHE   A CG   1 
ATOM   2235 C CD1  . PHE   A 1 168 ? 49.163 -1.224  16.593 1.00 17.17 ? 148 PHE   A CD1  1 
ATOM   2236 C CD2  . PHE   A 1 168 ? 49.370 -3.567  16.249 1.00 17.45 ? 148 PHE   A CD2  1 
ATOM   2237 C CE1  . PHE   A 1 168 ? 48.679 -1.462  17.865 1.00 19.86 ? 148 PHE   A CE1  1 
ATOM   2238 C CE2  . PHE   A 1 168 ? 48.892 -3.814  17.502 1.00 18.43 ? 148 PHE   A CE2  1 
ATOM   2239 C CZ   . PHE   A 1 168 ? 48.545 -2.757  18.322 1.00 20.42 ? 148 PHE   A CZ   1 
ATOM   2240 H H    . PHE   A 1 168 ? 47.714 -1.207  13.933 1.00 19.68 ? 148 PHE   A H    1 
ATOM   2241 H HA   . PHE   A 1 168 ? 49.915 -0.018  14.280 1.00 21.21 ? 148 PHE   A HA   1 
ATOM   2242 H HB2  . PHE   A 1 168 ? 49.706 -2.797  13.834 1.00 20.41 ? 148 PHE   A HB2  1 
ATOM   2243 H HB3  . PHE   A 1 168 ? 51.000 -2.096  14.435 1.00 20.41 ? 148 PHE   A HB3  1 
ATOM   2244 H HD1  . PHE   A 1 168 ? 49.262 -0.349  16.293 1.00 20.62 ? 148 PHE   A HD1  1 
ATOM   2245 H HD2  . PHE   A 1 168 ? 49.614 -4.282  15.706 1.00 20.95 ? 148 PHE   A HD2  1 
ATOM   2246 H HE1  . PHE   A 1 168 ? 48.442 -0.749  18.413 1.00 23.84 ? 148 PHE   A HE1  1 
ATOM   2247 H HE2  . PHE   A 1 168 ? 48.801 -4.689  17.804 1.00 22.13 ? 148 PHE   A HE2  1 
ATOM   2248 H HZ   . PHE   A 1 168 ? 48.222 -2.919  19.179 1.00 24.52 ? 148 PHE   A HZ   1 
ATOM   2249 N N    . ARG   A 1 169 ? 49.837 -1.506  11.401 1.00 17.92 ? 149 ARG   A N    1 
ATOM   2250 C CA   . ARG   A 1 169 ? 50.457 -1.581  10.083 1.00 17.26 ? 149 ARG   A CA   1 
ATOM   2251 C C    . ARG   A 1 169 ? 50.514 -0.217  9.423  1.00 18.93 ? 149 ARG   A C    1 
ATOM   2252 O O    . ARG   A 1 169 ? 51.534 0.157   8.821  1.00 20.21 ? 149 ARG   A O    1 
ATOM   2253 C CB   . ARG   A 1 169 ? 49.697 -2.557  9.181  1.00 20.71 ? 149 ARG   A CB   1 
ATOM   2254 C CG   . ARG   A 1 169 ? 49.994 -4.000  9.448  1.00 29.35 ? 149 ARG   A CG   1 
ATOM   2255 C CD   . ARG   A 1 169 ? 49.472 -4.914  8.358  1.00 27.28 ? 149 ARG   A CD   1 
ATOM   2256 N NE   . ARG   A 1 169 ? 50.026 -6.237  8.612  1.00 30.31 ? 149 ARG   A NE   1 
ATOM   2257 C CZ   . ARG   A 1 169 ? 49.527 -7.100  9.482  1.00 33.32 ? 149 ARG   A CZ   1 
ATOM   2258 N NH1  . ARG   A 1 169 ? 48.341 -6.912  10.040 1.00 30.34 ? 149 ARG   A NH1  1 
ATOM   2259 N NH2  . ARG   A 1 169 ? 50.243 -8.167  9.818  1.00 37.43 ? 149 ARG   A NH2  1 
ATOM   2260 H H    . ARG   A 1 169 ? 49.157 -2.023  11.502 1.00 21.52 ? 149 ARG   A H    1 
ATOM   2261 H HA   . ARG   A 1 169 ? 51.362 -1.911  10.199 1.00 20.72 ? 149 ARG   A HA   1 
ATOM   2262 H HB2  . ARG   A 1 169 ? 48.745 -2.423  9.314  1.00 24.87 ? 149 ARG   A HB2  1 
ATOM   2263 H HB3  . ARG   A 1 169 ? 49.933 -2.373  8.259  1.00 24.87 ? 149 ARG   A HB3  1 
ATOM   2264 H HG2  . ARG   A 1 169 ? 50.955 -4.121  9.506  1.00 35.23 ? 149 ARG   A HG2  1 
ATOM   2265 H HG3  . ARG   A 1 169 ? 49.576 -4.261  10.283 1.00 35.23 ? 149 ARG   A HG3  1 
ATOM   2266 H HD2  . ARG   A 1 169 ? 48.503 -4.958  8.388  1.00 32.75 ? 149 ARG   A HD2  1 
ATOM   2267 H HD3  . ARG   A 1 169 ? 49.763 -4.603  7.487  1.00 32.75 ? 149 ARG   A HD3  1 
ATOM   2268 H HE   . ARG   A 1 169 ? 50.724 -6.473  8.167  1.00 36.38 ? 149 ARG   A HE   1 
ATOM   2269 H HH11 . ARG   A 1 169 ? 47.876 -6.217  9.839  1.00 36.43 ? 149 ARG   A HH11 1 
ATOM   2270 H HH12 . ARG   A 1 169 ? 48.035 -7.486  10.603 1.00 36.43 ? 149 ARG   A HH12 1 
ATOM   2271 H HH21 . ARG   A 1 169 ? 51.020 -8.291  9.470  1.00 44.92 ? 149 ARG   A HH21 1 
ATOM   2272 H HH22 . ARG   A 1 169 ? 49.929 -8.735  10.382 1.00 44.92 ? 149 ARG   A HH22 1 
ATOM   2273 N N    . SER   A 1 170 ? 49.408 0.528   9.491  1.00 16.33 ? 150 SER   A N    1 
ATOM   2274 C CA   . SER   A 1 170 ? 49.333 1.806   8.805  1.00 16.31 ? 150 SER   A CA   1 
ATOM   2275 C C    . SER   A 1 170 ? 50.332 2.809   9.364  1.00 17.55 ? 150 SER   A C    1 
ATOM   2276 O O    . SER   A 1 170 ? 50.719 3.749   8.658  1.00 18.97 ? 150 SER   A O    1 
ATOM   2277 C CB   . SER   A 1 170 ? 47.927 2.391   8.896  1.00 17.32 ? 150 SER   A CB   1 
ATOM   2278 O OG   . SER   A 1 170 ? 47.637 2.841   10.205 1.00 18.15 ? 150 SER   A OG   1 
ATOM   2279 H H    . SER   A 1 170 ? 48.697 0.313   9.925  1.00 19.61 ? 150 SER   A H    1 
ATOM   2280 H HA   . SER   A 1 170 ? 49.532 1.656   7.868  1.00 19.59 ? 150 SER   A HA   1 
ATOM   2281 H HB2  . SER   A 1 170 ? 47.860 3.141   8.284  1.00 20.79 ? 150 SER   A HB2  1 
ATOM   2282 H HB3  . SER   A 1 170 ? 47.286 1.705   8.651  1.00 20.79 ? 150 SER   A HB3  1 
ATOM   2283 H HG   . SER   A 1 170 ? 46.991 3.379   10.188 1.00 21.79 ? 150 SER   A HG   1 
ATOM   2284 N N    . LEU   A 1 171 ? 50.729 2.641   10.618 1.00 15.13 ? 151 LEU   A N    1 
ATOM   2285 C CA   . LEU   A 1 171 ? 51.652 3.540   11.289 1.00 17.40 ? 151 LEU   A CA   1 
ATOM   2286 C C    . LEU   A 1 171 ? 53.081 3.028   11.263 1.00 17.02 ? 151 LEU   A C    1 
ATOM   2287 O O    . LEU   A 1 171 ? 53.966 3.661   11.851 1.00 21.20 ? 151 LEU   A O    1 
ATOM   2288 C CB   . LEU   A 1 171 ? 51.204 3.756   12.733 1.00 17.76 ? 151 LEU   A CB   1 
ATOM   2289 C CG   . LEU   A 1 171 ? 49.864 4.488   12.883 1.00 16.26 ? 151 LEU   A CG   1 
ATOM   2290 C CD1  . LEU   A 1 171 ? 49.327 4.306   14.291 1.00 17.62 ? 151 LEU   A CD1  1 
ATOM   2291 C CD2  . LEU   A 1 171 ? 50.009 5.966   12.550 1.00 17.34 ? 151 LEU   A CD2  1 
ATOM   2292 H H    . LEU   A 1 171 ? 50.468 1.990   11.117 1.00 18.17 ? 151 LEU   A H    1 
ATOM   2293 H HA   . LEU   A 1 171 ? 51.638 4.401   10.842 1.00 20.89 ? 151 LEU   A HA   1 
ATOM   2294 H HB2  . LEU   A 1 171 ? 51.115 2.890   13.160 1.00 21.32 ? 151 LEU   A HB2  1 
ATOM   2295 H HB3  . LEU   A 1 171 ? 51.879 4.283   13.189 1.00 21.32 ? 151 LEU   A HB3  1 
ATOM   2296 H HG   . LEU   A 1 171 ? 49.226 4.110   12.259 1.00 19.53 ? 151 LEU   A HG   1 
ATOM   2297 H HD11 . LEU   A 1 171 ? 48.476 4.766   14.366 1.00 21.16 ? 151 LEU   A HD11 1 
ATOM   2298 H HD12 . LEU   A 1 171 ? 49.207 3.359   14.463 1.00 21.16 ? 151 LEU   A HD12 1 
ATOM   2299 H HD13 . LEU   A 1 171 ? 49.962 4.679   14.922 1.00 21.16 ? 151 LEU   A HD13 1 
ATOM   2300 H HD21 . LEU   A 1 171 ? 49.179 6.420   12.763 1.00 20.82 ? 151 LEU   A HD21 1 
ATOM   2301 H HD22 . LEU   A 1 171 ? 50.734 6.339   13.075 1.00 20.82 ? 151 LEU   A HD22 1 
ATOM   2302 H HD23 . LEU   A 1 171 ? 50.203 6.059   11.604 1.00 20.82 ? 151 LEU   A HD23 1 
ATOM   2303 N N    . GLY   A 1 172 ? 53.329 1.906   10.592 1.00 18.63 ? 152 GLY   A N    1 
ATOM   2304 C CA   . GLY   A 1 172 ? 54.658 1.334   10.555 1.00 20.14 ? 152 GLY   A CA   1 
ATOM   2305 C C    . GLY   A 1 172 ? 55.077 0.672   11.839 1.00 22.13 ? 152 GLY   A C    1 
ATOM   2306 O O    . GLY   A 1 172 ? 56.272 0.456   12.057 1.00 24.31 ? 152 GLY   A O    1 
ATOM   2307 H H    . GLY   A 1 172 ? 52.741 1.461   10.150 1.00 22.37 ? 152 GLY   A H    1 
ATOM   2308 H HA2  . GLY   A 1 172 ? 54.694 0.669   9.850  1.00 24.18 ? 152 GLY   A HA2  1 
ATOM   2309 H HA3  . GLY   A 1 172 ? 55.297 2.037   10.358 1.00 24.18 ? 152 GLY   A HA3  1 
ATOM   2310 N N    . ILE   A 1 173 ? 54.121 0.348   12.705 1.00 20.80 ? 153 ILE   A N    1 
ATOM   2311 C CA   . ILE   A 1 173 ? 54.393 -0.321  13.969 1.00 20.06 ? 153 ILE   A CA   1 
ATOM   2312 C C    . ILE   A 1 173 ? 54.434 -1.820  13.710 1.00 22.06 ? 153 ILE   A C    1 
ATOM   2313 O O    . ILE   A 1 173 ? 53.545 -2.368  13.049 1.00 18.45 ? 153 ILE   A O    1 
ATOM   2314 C CB   . ILE   A 1 173 ? 53.322 0.030   15.014 1.00 19.43 ? 153 ILE   A CB   1 
ATOM   2315 C CG1  . ILE   A 1 173 ? 53.376 1.530   15.337 1.00 22.95 ? 153 ILE   A CG1  1 
ATOM   2316 C CG2  . ILE   A 1 173 ? 53.497 -0.824  16.263 1.00 21.48 ? 153 ILE   A CG2  1 
ATOM   2317 C CD1  . ILE   A 1 173 ? 52.183 2.031   16.103 1.00 21.11 ? 153 ILE   A CD1  1 
ATOM   2318 H H    . ILE   A 1 173 ? 53.286 0.511   12.577 1.00 24.98 ? 153 ILE   A H    1 
ATOM   2319 H HA   . ILE   A 1 173 ? 55.255 -0.038  14.313 1.00 24.08 ? 153 ILE   A HA   1 
ATOM   2320 H HB   . ILE   A 1 173 ? 52.445 -0.165  14.648 1.00 23.33 ? 153 ILE   A HB   1 
ATOM   2321 H HG12 . ILE   A 1 173 ? 54.166 1.705   15.871 1.00 27.55 ? 153 ILE   A HG12 1 
ATOM   2322 H HG13 . ILE   A 1 173 ? 53.422 2.026   14.504 1.00 27.55 ? 153 ILE   A HG13 1 
ATOM   2323 H HG21 . ILE   A 1 173 ? 53.002 -0.421  16.993 1.00 25.79 ? 153 ILE   A HG21 1 
ATOM   2324 H HG22 . ILE   A 1 173 ? 53.158 -1.715  16.086 1.00 25.79 ? 153 ILE   A HG22 1 
ATOM   2325 H HG23 . ILE   A 1 173 ? 54.440 -0.866  16.486 1.00 25.79 ? 153 ILE   A HG23 1 
ATOM   2326 H HD11 . ILE   A 1 173 ? 52.281 2.985   16.251 1.00 25.34 ? 153 ILE   A HD11 1 
ATOM   2327 H HD12 . ILE   A 1 173 ? 51.381 1.857   15.587 1.00 25.34 ? 153 ILE   A HD12 1 
ATOM   2328 H HD13 . ILE   A 1 173 ? 52.137 1.567   16.954 1.00 25.34 ? 153 ILE   A HD13 1 
ATOM   2329 N N    . GLU   A 1 174 ? 55.476 -2.485  14.197 1.00 22.86 ? 154 GLU   A N    1 
ATOM   2330 C CA   . GLU   A 1 174 ? 55.563 -3.930  14.016 1.00 21.42 ? 154 GLU   A CA   1 
ATOM   2331 C C    . GLU   A 1 174 ? 54.364 -4.605  14.665 1.00 21.96 ? 154 GLU   A C    1 
ATOM   2332 O O    . GLU   A 1 174 ? 54.032 -4.332  15.820 1.00 22.55 ? 154 GLU   A O    1 
ATOM   2333 C CB   . GLU   A 1 174 ? 56.862 -4.479  14.610 1.00 32.25 ? 154 GLU   A CB   1 
ATOM   2334 C CG   . GLU   A 1 174 ? 56.918 -5.996  14.586 1.00 31.57 ? 154 GLU   A CG   1 
ATOM   2335 H H    . GLU   A 1 174 ? 56.132 -2.132  14.626 1.00 27.44 ? 154 GLU   A H    1 
ATOM   2336 H HA   . GLU   A 1 174 ? 55.567 -4.131  13.067 1.00 25.72 ? 154 GLU   A HA   1 
ATOM   2337 H HB2  . GLU   A 1 174 ? 57.612 -4.141  14.096 1.00 38.72 ? 154 GLU   A HB2  1 
ATOM   2338 H HB3  . GLU   A 1 174 ? 56.935 -4.189  15.532 1.00 38.72 ? 154 GLU   A HB3  1 
ATOM   2339 N N    . VAL   A 1 175 ? 53.709 -5.476  13.909 1.00 20.16 ? 155 VAL   A N    1 
ATOM   2340 C CA   . VAL   A 1 175 ? 52.527 -6.176  14.392 1.00 20.96 ? 155 VAL   A CA   1 
ATOM   2341 C C    . VAL   A 1 175 ? 52.948 -7.433  15.136 1.00 21.94 ? 155 VAL   A C    1 
ATOM   2342 O O    . VAL   A 1 175 ? 53.705 -8.244  14.584 1.00 19.57 ? 155 VAL   A O    1 
ATOM   2343 C CB   . VAL   A 1 175 ? 51.578 -6.541  13.241 1.00 17.60 ? 155 VAL   A CB   1 
ATOM   2344 C CG1  . VAL   A 1 175 ? 50.345 -7.279  13.771 1.00 19.91 ? 155 VAL   A CG1  1 
ATOM   2345 C CG2  . VAL   A 1 175 ? 51.182 -5.301  12.459 1.00 24.74 ? 155 VAL   A CG2  1 
ATOM   2346 H H    . VAL   A 1 175 ? 53.933 -5.681  13.104 1.00 24.20 ? 155 VAL   A H    1 
ATOM   2347 H HA   . VAL   A 1 175 ? 52.063 -5.589  15.009 1.00 25.17 ? 155 VAL   A HA   1 
ATOM   2348 H HB   . VAL   A 1 175 ? 52.039 -7.138  12.631 1.00 21.13 ? 155 VAL   A HB   1 
ATOM   2349 H HG11 . VAL   A 1 175 ? 49.747 -7.467  13.031 1.00 23.90 ? 155 VAL   A HG11 1 
ATOM   2350 H HG12 . VAL   A 1 175 ? 50.629 -8.109  14.186 1.00 23.90 ? 155 VAL   A HG12 1 
ATOM   2351 H HG13 . VAL   A 1 175 ? 49.898 -6.719  14.425 1.00 23.90 ? 155 VAL   A HG13 1 
ATOM   2352 H HG21 . VAL   A 1 175 ? 50.488 -5.537  11.823 1.00 29.70 ? 155 VAL   A HG21 1 
ATOM   2353 H HG22 . VAL   A 1 175 ? 50.851 -4.630  13.076 1.00 29.70 ? 155 VAL   A HG22 1 
ATOM   2354 H HG23 . VAL   A 1 175 ? 51.960 -4.963  11.988 1.00 29.70 ? 155 VAL   A HG23 1 
ATOM   2355 N N    . PRO   A 1 176 ? 52.470 -7.644  16.361 1.00 19.51 ? 156 PRO   A N    1 
ATOM   2356 C CA   . PRO   A 1 176 ? 52.720 -8.923  17.037 1.00 23.25 ? 156 PRO   A CA   1 
ATOM   2357 C C    . PRO   A 1 176 ? 52.277 -10.079 16.153 1.00 21.38 ? 156 PRO   A C    1 
ATOM   2358 O O    . PRO   A 1 176 ? 51.323 -9.972  15.393 1.00 22.48 ? 156 PRO   A O    1 
ATOM   2359 C CB   . PRO   A 1 176 ? 51.874 -8.830  18.317 1.00 21.45 ? 156 PRO   A CB   1 
ATOM   2360 C CG   . PRO   A 1 176 ? 51.688 -7.334  18.543 1.00 25.32 ? 156 PRO   A CG   1 
ATOM   2361 C CD   . PRO   A 1 176 ? 51.621 -6.743  17.163 1.00 22.24 ? 156 PRO   A CD   1 
ATOM   2362 H HA   . PRO   A 1 176 ? 53.654 -9.021  17.279 1.00 27.92 ? 156 PRO   A HA   1 
ATOM   2363 H HB2  . PRO   A 1 176 ? 51.021 -9.272  18.185 1.00 25.75 ? 156 PRO   A HB2  1 
ATOM   2364 H HB3  . PRO   A 1 176 ? 52.348 -9.239  19.059 1.00 25.75 ? 156 PRO   A HB3  1 
ATOM   2365 H HG2  . PRO   A 1 176 ? 50.865 -7.172  19.030 1.00 30.40 ? 156 PRO   A HG2  1 
ATOM   2366 H HG3  . PRO   A 1 176 ? 52.443 -6.977  19.037 1.00 30.40 ? 156 PRO   A HG3  1 
ATOM   2367 H HD2  . PRO   A 1 176 ? 50.709 -6.744  16.833 1.00 26.70 ? 156 PRO   A HD2  1 
ATOM   2368 H HD3  . PRO   A 1 176 ? 51.975 -5.840  17.158 1.00 26.70 ? 156 PRO   A HD3  1 
ATOM   2369 N N    . GLU   A 1 177 ? 52.996 -11.187 16.234 1.00 25.72 ? 157 GLU   A N    1 
ATOM   2370 C CA   . GLU   A 1 177 ? 52.654 -12.384 15.479 1.00 23.90 ? 157 GLU   A CA   1 
ATOM   2371 C C    . GLU   A 1 177 ? 52.447 -13.526 16.458 1.00 25.85 ? 157 GLU   A C    1 
ATOM   2372 O O    . GLU   A 1 177 ? 53.228 -13.696 17.401 1.00 31.55 ? 157 GLU   A O    1 
ATOM   2373 C CB   . GLU   A 1 177 ? 53.742 -12.728 14.455 1.00 33.39 ? 157 GLU   A CB   1 
ATOM   2374 H H    . GLU   A 1 177 ? 53.697 -11.272 16.725 1.00 30.88 ? 157 GLU   A H    1 
ATOM   2375 H HA   . GLU   A 1 177 ? 51.829 -12.246 14.989 1.00 28.69 ? 157 GLU   A HA   1 
ATOM   2376 N N    . VAL   A 1 178 ? 51.367 -14.268 16.266 1.00 22.06 ? 158 VAL   A N    1 
ATOM   2377 C CA   . VAL   A 1 178 ? 51.165 -15.537 16.951 1.00 18.70 ? 158 VAL   A CA   1 
ATOM   2378 C C    . VAL   A 1 178 ? 51.844 -16.598 16.096 1.00 20.24 ? 158 VAL   A C    1 
ATOM   2379 O O    . VAL   A 1 178 ? 51.512 -16.756 14.917 1.00 21.97 ? 158 VAL   A O    1 
ATOM   2380 C CB   . VAL   A 1 178 ? 49.674 -15.840 17.151 1.00 21.33 ? 158 VAL   A CB   1 
ATOM   2381 C CG1  . VAL   A 1 178 ? 49.483 -17.239 17.677 1.00 24.12 ? 158 VAL   A CG1  1 
ATOM   2382 C CG2  . VAL   A 1 178 ? 49.065 -14.825 18.124 1.00 24.53 ? 158 VAL   A CG2  1 
ATOM   2383 H H    . VAL   A 1 178 ? 50.725 -14.055 15.734 1.00 26.48 ? 158 VAL   A H    1 
ATOM   2384 H HA   . VAL   A 1 178 ? 51.572 -15.519 17.831 1.00 22.46 ? 158 VAL   A HA   1 
ATOM   2385 H HB   . VAL   A 1 178 ? 49.220 -15.774 16.296 1.00 25.61 ? 158 VAL   A HB   1 
ATOM   2386 H HG11 . VAL   A 1 178 ? 48.558 -17.350 17.949 1.00 28.96 ? 158 VAL   A HG11 1 
ATOM   2387 H HG12 . VAL   A 1 178 ? 49.699 -17.873 16.975 1.00 28.96 ? 158 VAL   A HG12 1 
ATOM   2388 H HG13 . VAL   A 1 178 ? 50.070 -17.374 18.437 1.00 28.96 ? 158 VAL   A HG13 1 
ATOM   2389 H HG21 . VAL   A 1 178 ? 48.134 -15.053 18.276 1.00 29.45 ? 158 VAL   A HG21 1 
ATOM   2390 H HG22 . VAL   A 1 178 ? 49.554 -14.855 18.960 1.00 29.45 ? 158 VAL   A HG22 1 
ATOM   2391 H HG23 . VAL   A 1 178 ? 49.128 -13.938 17.735 1.00 29.45 ? 158 VAL   A HG23 1 
ATOM   2392 N N    . ARG   A 1 179 ? 52.842 -17.274 16.661 1.00 20.20 ? 159 ARG   A N    1 
ATOM   2393 C CA   . ARG   A 1 179 ? 53.521 -18.327 15.915 1.00 20.37 ? 159 ARG   A CA   1 
ATOM   2394 C C    . ARG   A 1 179 ? 52.545 -19.459 15.631 1.00 19.34 ? 159 ARG   A C    1 
ATOM   2395 O O    . ARG   A 1 179 ? 51.857 -19.937 16.533 1.00 19.71 ? 159 ARG   A O    1 
ATOM   2396 C CB   . ARG   A 1 179 ? 54.719 -18.851 16.704 1.00 24.48 ? 159 ARG   A CB   1 
ATOM   2397 C CG   . ARG   A 1 179 ? 55.845 -17.846 16.887 1.00 29.60 ? 159 ARG   A CG   1 
ATOM   2398 C CD   . ARG   A 1 179 ? 57.022 -18.508 17.596 1.00 31.26 ? 159 ARG   A CD   1 
ATOM   2399 N NE   . ARG   A 1 179 ? 56.594 -19.086 18.865 1.00 34.20 ? 159 ARG   A NE   1 
ATOM   2400 C CZ   . ARG   A 1 179 ? 56.599 -18.437 20.020 1.00 42.73 ? 159 ARG   A CZ   1 
ATOM   2401 N NH1  . ARG   A 1 179 ? 57.102 -17.216 20.126 1.00 32.91 ? 159 ARG   A NH1  1 
ATOM   2402 N NH2  . ARG   A 1 179 ? 56.075 -19.020 21.095 1.00 41.93 ? 159 ARG   A NH2  1 
ATOM   2403 H H    . ARG   A 1 179 ? 53.139 -17.144 17.457 1.00 24.25 ? 159 ARG   A H    1 
ATOM   2404 H HA   . ARG   A 1 179 ? 53.851 -17.972 15.075 1.00 24.46 ? 159 ARG   A HA   1 
ATOM   2405 H HB2  . ARG   A 1 179 ? 54.415 -19.114 17.587 1.00 29.39 ? 159 ARG   A HB2  1 
ATOM   2406 H HB3  . ARG   A 1 179 ? 55.084 -19.618 16.236 1.00 29.39 ? 159 ARG   A HB3  1 
ATOM   2407 H HG2  . ARG   A 1 179 ? 56.143 -17.527 16.021 1.00 35.54 ? 159 ARG   A HG2  1 
ATOM   2408 H HG3  . ARG   A 1 179 ? 55.535 -17.102 17.427 1.00 35.54 ? 159 ARG   A HG3  1 
ATOM   2409 H HD2  . ARG   A 1 179 ? 57.380 -19.216 17.038 1.00 37.53 ? 159 ARG   A HD2  1 
ATOM   2410 H HD3  . ARG   A 1 179 ? 57.708 -17.846 17.774 1.00 37.53 ? 159 ARG   A HD3  1 
ATOM   2411 H HE   . ARG   A 1 179 ? 56.320 -19.902 18.863 1.00 41.05 ? 159 ARG   A HE   1 
ATOM   2412 H HH11 . ARG   A 1 179 ? 57.435 -16.827 19.435 1.00 39.50 ? 159 ARG   A HH11 1 
ATOM   2413 H HH12 . ARG   A 1 179 ? 57.095 -16.813 20.885 1.00 39.50 ? 159 ARG   A HH12 1 
ATOM   2414 H HH21 . ARG   A 1 179 ? 55.738 -19.809 21.035 1.00 50.33 ? 159 ARG   A HH21 1 
ATOM   2415 H HH22 . ARG   A 1 179 ? 56.073 -18.608 21.849 1.00 50.33 ? 159 ARG   A HH22 1 
ATOM   2416 N N    . ARG   A 1 180 ? 52.488 -19.902 14.378 1.00 19.25 ? 160 ARG   A N    1 
ATOM   2417 C CA   . ARG   A 1 180 ? 51.475 -20.862 13.968 1.00 18.02 ? 160 ARG   A CA   1 
ATOM   2418 C C    . ARG   A 1 180 ? 52.015 -22.272 13.777 1.00 17.98 ? 160 ARG   A C    1 
ATOM   2419 O O    . ARG   A 1 180 ? 51.252 -23.163 13.383 1.00 22.18 ? 160 ARG   A O    1 
ATOM   2420 C CB   . ARG   A 1 180 ? 50.809 -20.412 12.673 1.00 22.79 ? 160 ARG   A CB   1 
ATOM   2421 C CG   . ARG   A 1 180 ? 50.063 -19.123 12.845 1.00 26.16 ? 160 ARG   A CG   1 
ATOM   2422 C CD   . ARG   A 1 180 ? 49.147 -18.854 11.691 1.00 29.50 ? 160 ARG   A CD   1 
ATOM   2423 N NE   . ARG   A 1 180 ? 48.757 -17.450 11.685 1.00 38.53 ? 160 ARG   A NE   1 
ATOM   2424 C CZ   . ARG   A 1 180 ? 47.883 -16.921 10.844 1.00 48.57 ? 160 ARG   A CZ   1 
ATOM   2425 N NH1  . ARG   A 1 180 ? 47.260 -17.661 9.941  1.00 45.27 ? 160 ARG   A NH1  1 
ATOM   2426 N NH2  . ARG   A 1 180 ? 47.632 -15.616 10.909 1.00 52.42 ? 160 ARG   A NH2  1 
ATOM   2427 H H    . ARG   A 1 180 ? 53.024 -19.660 13.751 1.00 23.12 ? 160 ARG   A H    1 
ATOM   2428 H HA   . ARG   A 1 180 ? 50.802 -20.893 14.665 1.00 21.64 ? 160 ARG   A HA   1 
ATOM   2429 H HB2  . ARG   A 1 180 ? 51.489 -20.281 11.994 1.00 27.36 ? 160 ARG   A HB2  1 
ATOM   2430 H HB3  . ARG   A 1 180 ? 50.180 -21.092 12.385 1.00 27.36 ? 160 ARG   A HB3  1 
ATOM   2431 H HG2  . ARG   A 1 180 ? 49.528 -19.168 13.653 1.00 31.40 ? 160 ARG   A HG2  1 
ATOM   2432 H HG3  . ARG   A 1 180 ? 50.697 -18.391 12.907 1.00 31.40 ? 160 ARG   A HG3  1 
ATOM   2433 H HD2  . ARG   A 1 180 ? 49.602 -19.054 10.859 1.00 35.41 ? 160 ARG   A HD2  1 
ATOM   2434 H HD3  . ARG   A 1 180 ? 48.349 -19.399 11.773 1.00 35.41 ? 160 ARG   A HD3  1 
ATOM   2435 H HE   . ARG   A 1 180 ? 49.118 -16.931 12.268 1.00 46.25 ? 160 ARG   A HE   1 
ATOM   2436 H HH11 . ARG   A 1 180 ? 47.420 -18.505 9.893  1.00 54.34 ? 160 ARG   A HH11 1 
ATOM   2437 H HH12 . ARG   A 1 180 ? 46.696 -17.299 9.403  1.00 54.34 ? 160 ARG   A HH12 1 
ATOM   2438 H HH21 . ARG   A 1 180 ? 48.034 -15.129 11.492 1.00 62.92 ? 160 ARG   A HH21 1 
ATOM   2439 H HH22 . ARG   A 1 180 ? 47.066 -15.259 10.368 1.00 62.92 ? 160 ARG   A HH22 1 
ATOM   2440 N N    . ASP   A 1 181 ? 53.293 -22.497 14.064 1.00 22.15 ? 161 ASP   A N    1 
ATOM   2441 C CA   . ASP   A 1 181 ? 53.893 -23.797 13.772 1.00 24.63 ? 161 ASP   A CA   1 
ATOM   2442 C C    . ASP   A 1 181 ? 53.133 -24.924 14.449 1.00 22.76 ? 161 ASP   A C    1 
ATOM   2443 O O    . ASP   A 1 181 ? 52.924 -25.988 13.853 1.00 27.62 ? 161 ASP   A O    1 
ATOM   2444 C CB   . ASP   A 1 181 ? 55.346 -23.782 14.215 1.00 22.77 ? 161 ASP   A CB   1 
ATOM   2445 C CG   . ASP   A 1 181 ? 56.117 -22.669 13.564 1.00 30.97 ? 161 ASP   A CG   1 
ATOM   2446 O OD1  . ASP   A 1 181 ? 56.488 -22.828 12.384 1.00 39.00 ? 161 ASP   A OD1  1 
ATOM   2447 O OD2  . ASP   A 1 181 ? 56.299 -21.617 14.206 1.00 32.89 ? 161 ASP   A OD2  1 
ATOM   2448 H H    . ASP   A 1 181 ? 53.827 -21.926 14.422 1.00 26.59 ? 161 ASP   A H    1 
ATOM   2449 H HA   . ASP   A 1 181 ? 53.861 -23.959 12.817 1.00 29.57 ? 161 ASP   A HA   1 
ATOM   2450 H HB2  . ASP   A 1 181 ? 55.387 -23.658 15.176 1.00 27.33 ? 161 ASP   A HB2  1 
ATOM   2451 H HB3  . ASP   A 1 181 ? 55.763 -24.624 13.972 1.00 27.33 ? 161 ASP   A HB3  1 
ATOM   2452 N N    . GLY   A 1 182 ? 52.710 -24.716 15.690 1.00 20.23 ? 162 GLY   A N    1 
ATOM   2453 C CA   . GLY   A 1 182 ? 52.054 -25.755 16.444 1.00 19.00 ? 162 GLY   A CA   1 
ATOM   2454 C C    . GLY   A 1 182 ? 50.594 -25.928 16.150 1.00 21.23 ? 162 GLY   A C    1 
ATOM   2455 O O    . GLY   A 1 182 ? 49.942 -26.818 16.700 1.00 26.29 ? 162 GLY   A O    1 
ATOM   2456 H H    . GLY   A 1 182 ? 52.796 -23.972 16.113 1.00 24.29 ? 162 GLY   A H    1 
ATOM   2457 H HA2  . GLY   A 1 182 ? 52.495 -26.599 16.257 1.00 22.81 ? 162 GLY   A HA2  1 
ATOM   2458 H HA3  . GLY   A 1 182 ? 52.143 -25.555 17.389 1.00 22.81 ? 162 GLY   A HA3  1 
ATOM   2459 N N    . LEU   A 1 183 ? 50.057 -25.095 15.263 1.00 24.07 ? 163 LEU   A N    1 
ATOM   2460 C CA   . LEU   A 1 183 ? 48.631 -25.023 15.013 1.00 28.90 ? 163 LEU   A CA   1 
ATOM   2461 C C    . LEU   A 1 183 ? 48.276 -25.775 13.740 1.00 27.75 ? 163 LEU   A C    1 
ATOM   2462 O O    . LEU   A 1 183 ? 49.012 -25.697 12.743 1.00 32.23 ? 163 LEU   A O    1 
ATOM   2463 C CB   . LEU   A 1 183 ? 48.198 -23.564 14.885 1.00 28.27 ? 163 LEU   A CB   1 
ATOM   2464 C CG   . LEU   A 1 183 ? 48.574 -22.670 16.067 1.00 33.27 ? 163 LEU   A CG   1 
ATOM   2465 C CD1  . LEU   A 1 183 ? 48.291 -21.213 15.739 1.00 44.75 ? 163 LEU   A CD1  1 
ATOM   2466 C CD2  . LEU   A 1 183 ? 47.829 -23.088 17.328 1.00 27.00 ? 163 LEU   A CD2  1 
ATOM   2467 H H    . LEU   A 1 183 ? 50.513 -24.547 14.782 1.00 28.90 ? 163 LEU   A H    1 
ATOM   2468 H HA   . LEU   A 1 183 ? 48.141 -25.425 15.747 1.00 34.69 ? 163 LEU   A HA   1 
ATOM   2469 H HB2  . LEU   A 1 183 ? 48.615 -23.190 14.093 1.00 33.94 ? 163 LEU   A HB2  1 
ATOM   2470 H HB3  . LEU   A 1 183 ? 47.233 -23.538 14.796 1.00 33.94 ? 163 LEU   A HB3  1 
ATOM   2471 H HG   . LEU   A 1 183 ? 49.523 -22.766 16.240 1.00 39.94 ? 163 LEU   A HG   1 
ATOM   2472 H HD11 . LEU   A 1 183 ? 49.023 -20.667 16.067 1.00 53.71 ? 163 LEU   A HD11 1 
ATOM   2473 H HD12 . LEU   A 1 183 ? 48.210 -21.115 14.777 1.00 53.71 ? 163 LEU   A HD12 1 
ATOM   2474 H HD13 . LEU   A 1 183 ? 47.463 -20.947 16.169 1.00 53.71 ? 163 LEU   A HD13 1 
ATOM   2475 H HD21 . LEU   A 1 183 ? 48.004 -22.439 18.028 1.00 32.41 ? 163 LEU   A HD21 1 
ATOM   2476 H HD22 . LEU   A 1 183 ? 46.878 -23.120 17.138 1.00 32.41 ? 163 LEU   A HD22 1 
ATOM   2477 H HD23 . LEU   A 1 183 ? 48.141 -23.964 17.603 1.00 32.41 ? 163 LEU   A HD23 1 
ATOM   2478 N N    . PRO   A 1 184 ? 47.180 -26.529 13.760 1.00 23.94 ? 164 PRO   A N    1 
ATOM   2479 C CA   . PRO   A 1 184 ? 46.759 -27.235 12.545 1.00 22.97 ? 164 PRO   A CA   1 
ATOM   2480 C C    . PRO   A 1 184 ? 46.517 -26.264 11.400 1.00 31.50 ? 164 PRO   A C    1 
ATOM   2481 O O    . PRO   A 1 184 ? 45.944 -25.188 11.577 1.00 30.61 ? 164 PRO   A O    1 
ATOM   2482 C CB   . PRO   A 1 184 ? 45.469 -27.942 12.973 1.00 31.73 ? 164 PRO   A CB   1 
ATOM   2483 C CG   . PRO   A 1 184 ? 45.621 -28.134 14.444 1.00 39.00 ? 164 PRO   A CG   1 
ATOM   2484 C CD   . PRO   A 1 184 ? 46.378 -26.925 14.934 1.00 31.83 ? 164 PRO   A CD   1 
ATOM   2485 H HA   . PRO   A 1 184 ? 47.420 -27.894 12.282 1.00 27.58 ? 164 PRO   A HA   1 
ATOM   2486 H HB2  . PRO   A 1 184 ? 44.702 -27.384 12.771 1.00 38.09 ? 164 PRO   A HB2  1 
ATOM   2487 H HB3  . PRO   A 1 184 ? 45.390 -28.794 12.515 1.00 38.09 ? 164 PRO   A HB3  1 
ATOM   2488 H HG2  . PRO   A 1 184 ? 44.746 -28.186 14.860 1.00 46.81 ? 164 PRO   A HG2  1 
ATOM   2489 H HG3  . PRO   A 1 184 ? 46.120 -28.948 14.619 1.00 46.81 ? 164 PRO   A HG3  1 
ATOM   2490 H HD2  . PRO   A 1 184 ? 45.768 -26.216 15.191 1.00 38.21 ? 164 PRO   A HD2  1 
ATOM   2491 H HD3  . PRO   A 1 184 ? 46.951 -27.156 15.682 1.00 38.21 ? 164 PRO   A HD3  1 
ATOM   2492 N N    . SER   A 1 185 ? 46.967 -26.654 10.217 1.00 44.85 ? 165 SER   A N    1 
ATOM   2493 C CA   . SER   A 1 185 ? 46.761 -25.837 9.031  1.00 57.24 ? 165 SER   A CA   1 
ATOM   2494 C C    . SER   A 1 185 ? 46.429 -26.726 7.840  1.00 68.23 ? 165 SER   A C    1 
ATOM   2495 O O    . SER   A 1 185 ? 45.681 -26.328 6.949  1.00 82.14 ? 165 SER   A O    1 
ATOM   2496 C CB   . SER   A 1 185 ? 47.997 -24.988 8.745  1.00 40.85 ? 165 SER   A CB   1 
ATOM   2497 O OXT  . SER   A 1 185 ? 46.892 -27.862 7.747  1.00 66.44 ? 165 SER   A OXT  1 
ATOM   2498 H H    . SER   A 1 185 ? 47.394 -27.386 10.074 1.00 53.84 ? 165 SER   A H    1 
ATOM   2499 H HA   . SER   A 1 185 ? 46.020 -25.228 9.173  1.00 68.70 ? 165 SER   A HA   1 
ATOM   2500 N N    . ASN   B 1 33  ? 6.521  -13.881 3.406  1.00 49.15 ? 13  ASN   B N    1 
ATOM   2501 C CA   . ASN   B 1 33  ? 6.735  -13.339 4.742  1.00 48.43 ? 13  ASN   B CA   1 
ATOM   2502 C C    . ASN   B 1 33  ? 6.694  -14.445 5.793  1.00 66.59 ? 13  ASN   B C    1 
ATOM   2503 O O    . ASN   B 1 33  ? 7.415  -14.392 6.791  1.00 73.10 ? 13  ASN   B O    1 
ATOM   2504 C CB   . ASN   B 1 33  ? 5.691  -12.264 5.060  1.00 63.68 ? 13  ASN   B CB   1 
ATOM   2505 C CG   . ASN   B 1 33  ? 6.101  -11.372 6.220  1.00 82.12 ? 13  ASN   B CG   1 
ATOM   2506 O OD1  . ASN   B 1 33  ? 5.572  -11.487 7.326  1.00 56.98 ? 13  ASN   B OD1  1 
ATOM   2507 N ND2  . ASN   B 1 33  ? 7.048  -10.477 5.970  1.00 79.11 ? 13  ASN   B ND2  1 
ATOM   2508 N N    . ARG   B 1 34  ? 5.846  -15.451 5.563  1.00 73.03 ? 14  ARG   B N    1 
ATOM   2509 C CA   . ARG   B 1 34  ? 5.736  -16.554 6.514  1.00 52.18 ? 14  ARG   B CA   1 
ATOM   2510 C C    . ARG   B 1 34  ? 7.034  -17.345 6.587  1.00 46.52 ? 14  ARG   B C    1 
ATOM   2511 O O    . ARG   B 1 34  ? 7.482  -17.720 7.677  1.00 41.07 ? 14  ARG   B O    1 
ATOM   2512 C CB   . ARG   B 1 34  ? 4.576  -17.469 6.124  1.00 62.89 ? 14  ARG   B CB   1 
ATOM   2513 H HA   . ARG   B 1 34  ? 5.550  -16.191 7.394  1.00 62.62 ? 14  ARG   B HA   1 
ATOM   2514 N N    . ALA   B 1 35  ? 7.652  -17.621 5.436  1.00 40.43 ? 15  ALA   B N    1 
ATOM   2515 C CA   . ALA   B 1 35  ? 8.965  -18.254 5.454  1.00 63.81 ? 15  ALA   B CA   1 
ATOM   2516 C C    . ALA   B 1 35  ? 9.954  -17.440 6.278  1.00 56.55 ? 15  ALA   B C    1 
ATOM   2517 O O    . ALA   B 1 35  ? 10.855 -18.006 6.903  1.00 37.46 ? 15  ALA   B O    1 
ATOM   2518 C CB   . ALA   B 1 35  ? 9.485  -18.438 4.028  1.00 46.64 ? 15  ALA   B CB   1 
ATOM   2519 H H    . ALA   B 1 35  ? 7.338  -17.454 4.653  1.00 48.53 ? 15  ALA   B H    1 
ATOM   2520 H HA   . ALA   B 1 35  ? 8.884  -19.134 5.855  1.00 76.59 ? 15  ALA   B HA   1 
ATOM   2521 H HB1  . ALA   B 1 35  ? 8.841  -18.958 3.521  1.00 55.98 ? 15  ALA   B HB1  1 
ATOM   2522 H HB2  . ALA   B 1 35  ? 9.601  -17.567 3.619  1.00 55.98 ? 15  ALA   B HB2  1 
ATOM   2523 H HB3  . ALA   B 1 35  ? 10.334 -18.905 4.059  1.00 55.98 ? 15  ALA   B HB3  1 
ATOM   2524 N N    . GLN   B 1 36  ? 9.782  -16.117 6.318  1.00 56.11 ? 16  GLN   B N    1 
ATOM   2525 C CA   . GLN   B 1 36  ? 10.795 -15.247 6.908  1.00 50.96 ? 16  GLN   B CA   1 
ATOM   2526 C C    . GLN   B 1 36  ? 10.748 -15.272 8.431  1.00 40.74 ? 16  GLN   B C    1 
ATOM   2527 O O    . GLN   B 1 36  ? 11.773 -15.487 9.085  1.00 31.43 ? 16  GLN   B O    1 
ATOM   2528 C CB   . GLN   B 1 36  ? 10.616 -13.818 6.393  1.00 53.54 ? 16  GLN   B CB   1 
ATOM   2529 C CG   . GLN   B 1 36  ? 10.776 -13.676 4.888  1.00 50.57 ? 16  GLN   B CG   1 
ATOM   2530 H H    . GLN   B 1 36  ? 9.094  -15.703 6.011  1.00 67.35 ? 16  GLN   B H    1 
ATOM   2531 H HA   . GLN   B 1 36  ? 11.669 -15.566 6.636  1.00 61.17 ? 16  GLN   B HA   1 
ATOM   2532 H HB2  . GLN   B 1 36  ? 9.725  -13.513 6.625  1.00 64.26 ? 16  GLN   B HB2  1 
ATOM   2533 H HB3  . GLN   B 1 36  ? 11.280 -13.250 6.815  1.00 64.26 ? 16  GLN   B HB3  1 
ATOM   2534 H HG2  . GLN   B 1 36  ? 11.411 -14.337 4.574  1.00 60.70 ? 16  GLN   B HG2  1 
ATOM   2535 H HG3  . GLN   B 1 36  ? 9.915  -13.816 4.463  1.00 60.70 ? 16  GLN   B HG3  1 
ATOM   2536 N N    . VAL   B 1 37  ? 9.577  -15.029 9.018  1.00 26.91 ? 17  VAL   B N    1 
ATOM   2537 C CA   . VAL   B 1 37  ? 9.455  -15.097 10.471 1.00 40.16 ? 17  VAL   B CA   1 
ATOM   2538 C C    . VAL   B 1 37  ? 9.854  -16.481 10.969 1.00 34.44 ? 17  VAL   B C    1 
ATOM   2539 O O    . VAL   B 1 37  ? 10.455 -16.624 12.040 1.00 31.00 ? 17  VAL   B O    1 
ATOM   2540 C CB   . VAL   B 1 37  ? 8.023  -14.728 10.906 1.00 36.28 ? 17  VAL   B CB   1 
ATOM   2541 C CG1  . VAL   B 1 37  ? 7.897  -14.780 12.423 1.00 45.77 ? 17  VAL   B CG1  1 
ATOM   2542 C CG2  . VAL   B 1 37  ? 7.652  -13.351 10.383 1.00 56.03 ? 17  VAL   B CG2  1 
ATOM   2543 H H    . VAL   B 1 37  ? 8.850  -14.826 8.605  1.00 32.30 ? 17  VAL   B H    1 
ATOM   2544 H HA   . VAL   B 1 37  ? 10.062 -14.450 10.863 1.00 48.21 ? 17  VAL   B HA   1 
ATOM   2545 H HB   . VAL   B 1 37  ? 7.402  -15.372 10.532 1.00 43.55 ? 17  VAL   B HB   1 
ATOM   2546 H HG11 . VAL   B 1 37  ? 7.011  -14.477 12.676 1.00 54.94 ? 17  VAL   B HG11 1 
ATOM   2547 H HG12 . VAL   B 1 37  ? 8.032  -15.693 12.720 1.00 54.94 ? 17  VAL   B HG12 1 
ATOM   2548 H HG13 . VAL   B 1 37  ? 8.569  -14.201 12.815 1.00 54.94 ? 17  VAL   B HG13 1 
ATOM   2549 H HG21 . VAL   B 1 37  ? 6.759  -13.128 10.687 1.00 67.24 ? 17  VAL   B HG21 1 
ATOM   2550 H HG22 . VAL   B 1 37  ? 8.289  -12.702 10.721 1.00 67.24 ? 17  VAL   B HG22 1 
ATOM   2551 H HG23 . VAL   B 1 37  ? 7.677  -13.365 9.413  1.00 67.24 ? 17  VAL   B HG23 1 
ATOM   2552 N N    . ALA   B 1 38  ? 9.519  -17.519 10.202 1.00 38.48 ? 18  ALA   B N    1 
ATOM   2553 C CA   . ALA   B 1 38  ? 9.835  -18.884 10.606 1.00 36.17 ? 18  ALA   B CA   1 
ATOM   2554 C C    . ALA   B 1 38  ? 11.327 -19.158 10.502 1.00 23.63 ? 18  ALA   B C    1 
ATOM   2555 O O    . ALA   B 1 38  ? 11.922 -19.765 11.404 1.00 28.19 ? 18  ALA   B O    1 
ATOM   2556 C CB   . ALA   B 1 38  ? 9.049  -19.869 9.741  1.00 32.94 ? 18  ALA   B CB   1 
ATOM   2557 H H    . ALA   B 1 38  ? 9.111  -17.459 9.447  1.00 46.19 ? 18  ALA   B H    1 
ATOM   2558 H HA   . ALA   B 1 38  ? 9.572  -19.008 11.532 1.00 43.42 ? 18  ALA   B HA   1 
ATOM   2559 H HB1  . ALA   B 1 38  ? 9.264  -19.712 8.808  1.00 39.54 ? 18  ALA   B HB1  1 
ATOM   2560 H HB2  . ALA   B 1 38  ? 8.100  -19.732 9.889  1.00 39.54 ? 18  ALA   B HB2  1 
ATOM   2561 H HB3  . ALA   B 1 38  ? 9.295  -20.774 9.989  1.00 39.54 ? 18  ALA   B HB3  1 
ATOM   2562 N N    . ALA   B 1 39  ? 11.940 -18.748 9.391  1.00 23.75 ? 19  ALA   B N    1 
ATOM   2563 C CA   . ALA   B 1 39  ? 13.383 -18.884 9.253  1.00 28.77 ? 19  ALA   B CA   1 
ATOM   2564 C C    . ALA   B 1 39  ? 14.101 -18.163 10.384 1.00 27.23 ? 19  ALA   B C    1 
ATOM   2565 O O    . ALA   B 1 39  ? 15.052 -18.693 10.971 1.00 21.11 ? 19  ALA   B O    1 
ATOM   2566 C CB   . ALA   B 1 39  ? 13.834 -18.333 7.903  1.00 28.57 ? 19  ALA   B CB   1 
ATOM   2567 H H    . ALA   B 1 39  ? 11.547 -18.393 8.714  1.00 28.51 ? 19  ALA   B H    1 
ATOM   2568 H HA   . ALA   B 1 39  ? 13.618 -19.824 9.288  1.00 34.54 ? 19  ALA   B HA   1 
ATOM   2569 H HB1  . ALA   B 1 39  ? 14.803 -18.296 7.885  1.00 34.29 ? 19  ALA   B HB1  1 
ATOM   2570 H HB2  . ALA   B 1 39  ? 13.512 -18.918 7.200  1.00 34.29 ? 19  ALA   B HB2  1 
ATOM   2571 H HB3  . ALA   B 1 39  ? 13.467 -17.442 7.787  1.00 34.29 ? 19  ALA   B HB3  1 
ATOM   2572 N N    . ARG   B 1 40  ? 13.653 -16.954 10.708 1.00 25.30 ? 20  ARG   B N    1 
ATOM   2573 C CA   . ARG   B 1 40  ? 14.319 -16.173 11.742 1.00 23.95 ? 20  ARG   B CA   1 
ATOM   2574 C C    . ARG   B 1 40  ? 14.220 -16.863 13.097 1.00 21.83 ? 20  ARG   B C    1 
ATOM   2575 O O    . ARG   B 1 40  ? 15.213 -16.993 13.806 1.00 20.79 ? 20  ARG   B O    1 
ATOM   2576 C CB   . ARG   B 1 40  ? 13.727 -14.759 11.798 1.00 23.09 ? 20  ARG   B CB   1 
ATOM   2577 C CG   . ARG   B 1 40  ? 14.478 -13.837 12.742 1.00 23.26 ? 20  ARG   B CG   1 
ATOM   2578 C CD   . ARG   B 1 40  ? 13.951 -12.416 12.718 1.00 20.67 ? 20  ARG   B CD   1 
ATOM   2579 N NE   . ARG   B 1 40  ? 14.332 -11.695 11.512 1.00 23.00 ? 20  ARG   B NE   1 
ATOM   2580 C CZ   . ARG   B 1 40  ? 13.504 -11.412 10.517 1.00 23.12 ? 20  ARG   B CZ   1 
ATOM   2581 N NH1  . ARG   B 1 40  ? 12.233 -11.782 10.550 1.00 28.81 ? 20  ARG   B NH1  1 
ATOM   2582 N NH2  . ARG   B 1 40  ? 13.957 -10.733 9.468  1.00 22.30 ? 20  ARG   B NH2  1 
ATOM   2583 H H    . ARG   B 1 40  ? 12.974 -16.568 10.349 1.00 30.38 ? 20  ARG   B H    1 
ATOM   2584 H HA   . ARG   B 1 40  ? 15.259 -16.092 11.519 1.00 28.76 ? 20  ARG   B HA   1 
ATOM   2585 H HB2  . ARG   B 1 40  ? 13.761 -14.369 10.910 1.00 27.72 ? 20  ARG   B HB2  1 
ATOM   2586 H HB3  . ARG   B 1 40  ? 12.808 -14.814 12.101 1.00 27.72 ? 20  ARG   B HB3  1 
ATOM   2587 H HG2  . ARG   B 1 40  ? 14.390 -14.173 13.648 1.00 27.93 ? 20  ARG   B HG2  1 
ATOM   2588 H HG3  . ARG   B 1 40  ? 15.413 -13.814 12.485 1.00 27.93 ? 20  ARG   B HG3  1 
ATOM   2589 H HD2  . ARG   B 1 40  ? 12.983 -12.437 12.762 1.00 24.82 ? 20  ARG   B HD2  1 
ATOM   2590 H HD3  . ARG   B 1 40  ? 14.308 -11.934 13.480 1.00 24.82 ? 20  ARG   B HD3  1 
ATOM   2591 H HE   . ARG   B 1 40  ? 15.149 -11.435 11.440 1.00 27.62 ? 20  ARG   B HE   1 
ATOM   2592 H HH11 . ARG   B 1 40  ? 11.712 -11.588 9.893  1.00 34.58 ? 20  ARG   B HH11 1 
ATOM   2593 H HH12 . ARG   B 1 40  ? 11.928 -12.215 11.227 1.00 34.58 ? 20  ARG   B HH12 1 
ATOM   2594 H HH21 . ARG   B 1 40  ? 14.779 -10.482 9.440  1.00 26.77 ? 20  ARG   B HH21 1 
ATOM   2595 H HH22 . ARG   B 1 40  ? 13.428 -10.544 8.816  1.00 26.77 ? 20  ARG   B HH22 1 
ATOM   2596 N N    . GLN   B 1 41  ? 13.030 -17.335 13.475 1.00 22.08 ? 21  GLN   B N    1 
ATOM   2597 C CA   . GLN   B 1 41  ? 12.897 -17.987 14.776 1.00 20.12 ? 21  GLN   B CA   1 
ATOM   2598 C C    . GLN   B 1 41  ? 13.688 -19.289 14.832 1.00 17.43 ? 21  GLN   B C    1 
ATOM   2599 O O    . GLN   B 1 41  ? 14.281 -19.620 15.862 1.00 20.23 ? 21  GLN   B O    1 
ATOM   2600 C CB   . GLN   B 1 41  ? 11.424 -18.247 15.086 1.00 27.07 ? 21  GLN   B CB   1 
ATOM   2601 C CG   . GLN   B 1 41  ? 10.768 -17.124 15.858 1.00 40.24 ? 21  GLN   B CG   1 
ATOM   2602 H H    . GLN   B 1 41  ? 12.307 -17.292 13.011 1.00 26.51 ? 21  GLN   B H    1 
ATOM   2603 H HA   . GLN   B 1 41  ? 13.249 -17.391 15.455 1.00 24.16 ? 21  GLN   B HA   1 
ATOM   2604 H HB2  . GLN   B 1 41  ? 10.943 -18.357 14.252 1.00 32.49 ? 21  GLN   B HB2  1 
ATOM   2605 H HB3  . GLN   B 1 41  ? 11.354 -19.055 15.619 1.00 32.49 ? 21  GLN   B HB3  1 
ATOM   2606 N N    . HIS   B 1 42  ? 13.696 -20.042 13.731 1.00 18.18 ? 22  HIS   B N    1 
ATOM   2607 C CA   . HIS   B 1 42  ? 14.516 -21.247 13.652 1.00 17.22 ? 22  HIS   B CA   1 
ATOM   2608 C C    . HIS   B 1 42  ? 15.986 -20.914 13.827 1.00 17.12 ? 22  HIS   B C    1 
ATOM   2609 O O    . HIS   B 1 42  ? 16.686 -21.531 14.638 1.00 16.40 ? 22  HIS   B O    1 
ATOM   2610 C CB   . HIS   B 1 42  ? 14.292 -21.918 12.302 1.00 19.25 ? 22  HIS   B CB   1 
ATOM   2611 C CG   . HIS   B 1 42  ? 15.219 -23.055 12.018 1.00 17.66 ? 22  HIS   B CG   1 
ATOM   2612 N ND1  . HIS   B 1 42  ? 14.834 -24.370 12.165 1.00 20.76 ? 22  HIS   B ND1  1 
ATOM   2613 C CD2  . HIS   B 1 42  ? 16.495 -23.082 11.562 1.00 19.14 ? 22  HIS   B CD2  1 
ATOM   2614 C CE1  . HIS   B 1 42  ? 15.836 -25.158 11.818 1.00 19.08 ? 22  HIS   B CE1  1 
ATOM   2615 N NE2  . HIS   B 1 42  ? 16.856 -24.404 11.451 1.00 21.08 ? 22  HIS   B NE2  1 
ATOM   2616 H H    . HIS   B 1 42  ? 13.238 -19.878 13.022 1.00 21.83 ? 22  HIS   B H    1 
ATOM   2617 H HA   . HIS   B 1 42  ? 14.253 -21.859 14.358 1.00 20.68 ? 22  HIS   B HA   1 
ATOM   2618 H HB2  . HIS   B 1 42  ? 13.386 -22.264 12.274 1.00 23.11 ? 22  HIS   B HB2  1 
ATOM   2619 H HB3  . HIS   B 1 42  ? 14.416 -21.257 11.603 1.00 23.11 ? 22  HIS   B HB3  1 
ATOM   2620 H HD2  . HIS   B 1 42  ? 17.026 -22.346 11.362 1.00 22.98 ? 22  HIS   B HD2  1 
ATOM   2621 H HE1  . HIS   B 1 42  ? 15.825 -26.088 11.831 1.00 22.91 ? 22  HIS   B HE1  1 
ATOM   2622 H HE2  . HIS   B 1 42  ? 17.621 -24.692 11.186 1.00 25.31 ? 22  HIS   B HE2  1 
ATOM   2623 N N    . ASN   B 1 43  ? 16.472 -19.951 13.044 1.00 17.91 ? 23  ASN   B N    1 
ATOM   2624 C CA   . ASN   B 1 43  ? 17.887 -19.603 13.095 1.00 15.76 ? 23  ASN   B CA   1 
ATOM   2625 C C    . ASN   B 1 43  ? 18.274 -19.058 14.461 1.00 16.12 ? 23  ASN   B C    1 
ATOM   2626 O O    . ASN   B 1 43  ? 19.372 -19.325 14.951 1.00 15.17 ? 23  ASN   B O    1 
ATOM   2627 C CB   . ASN   B 1 43  ? 18.201 -18.591 12.001 1.00 17.36 ? 23  ASN   B CB   1 
ATOM   2628 C CG   . ASN   B 1 43  ? 17.998 -19.162 10.608 1.00 14.94 ? 23  ASN   B CG   1 
ATOM   2629 O OD1  . ASN   B 1 43  ? 17.980 -20.377 10.419 1.00 18.05 ? 23  ASN   B OD1  1 
ATOM   2630 N ND2  . ASN   B 1 43  ? 17.856 -18.285 9.624  1.00 17.28 ? 23  ASN   B ND2  1 
ATOM   2631 H H    . ASN   B 1 43  ? 16.009 -19.491 12.484 1.00 21.50 ? 23  ASN   B H    1 
ATOM   2632 H HA   . ASN   B 1 43  ? 18.416 -20.400 12.936 1.00 18.92 ? 23  ASN   B HA   1 
ATOM   2633 H HB2  . ASN   B 1 43  ? 17.617 -17.823 12.101 1.00 20.84 ? 23  ASN   B HB2  1 
ATOM   2634 H HB3  . ASN   B 1 43  ? 19.128 -18.314 12.081 1.00 20.84 ? 23  ASN   B HB3  1 
ATOM   2635 H HD21 . ASN   B 1 43  ? 17.739 -18.558 8.817  1.00 20.75 ? 23  ASN   B HD21 1 
ATOM   2636 H HD22 . ASN   B 1 43  ? 17.882 -17.442 9.793  1.00 20.75 ? 23  ASN   B HD22 1 
ATOM   2637 N N    . ARG   B 1 44  ? 17.385 -18.300 15.098 1.00 16.97 ? 24  ARG   B N    1 
ATOM   2638 C CA   . ARG   B 1 44  ? 17.673 -17.816 16.442 1.00 14.24 ? 24  ARG   B CA   1 
ATOM   2639 C C    . ARG   B 1 44  ? 17.945 -18.973 17.391 1.00 15.58 ? 24  ARG   B C    1 
ATOM   2640 O O    . ARG   B 1 44  ? 18.859 -18.907 18.221 1.00 16.26 ? 24  ARG   B O    1 
ATOM   2641 C CB   . ARG   B 1 44  ? 16.511 -16.971 16.966 1.00 17.33 ? 24  ARG   B CB   1 
ATOM   2642 C CG   . ARG   B 1 44  ? 16.600 -16.689 18.445 1.00 24.20 ? 24  ARG   B CG   1 
ATOM   2643 C CD   . ARG   B 1 44  ? 15.380 -15.932 18.929 1.00 36.46 ? 24  ARG   B CD   1 
ATOM   2644 N NE   . ARG   B 1 44  ? 15.550 -14.499 18.735 1.00 53.22 ? 24  ARG   B NE   1 
ATOM   2645 C CZ   . ARG   B 1 44  ? 16.253 -13.720 19.546 1.00 43.34 ? 24  ARG   B CZ   1 
ATOM   2646 N NH1  . ARG   B 1 44  ? 16.846 -14.202 20.623 1.00 35.49 ? 24  ARG   B NH1  1 
ATOM   2647 N NH2  . ARG   B 1 44  ? 16.365 -12.426 19.264 1.00 43.51 ? 24  ARG   B NH2  1 
ATOM   2648 H H    . ARG   B 1 44  ? 16.624 -18.056 14.780 1.00 20.38 ? 24  ARG   B H    1 
ATOM   2649 H HA   . ARG   B 1 44  ? 18.461 -17.252 16.405 1.00 17.10 ? 24  ARG   B HA   1 
ATOM   2650 H HB2  . ARG   B 1 44  ? 16.507 -16.120 16.500 1.00 20.81 ? 24  ARG   B HB2  1 
ATOM   2651 H HB3  . ARG   B 1 44  ? 15.680 -17.444 16.802 1.00 20.81 ? 24  ARG   B HB3  1 
ATOM   2652 H HG2  . ARG   B 1 44  ? 16.655 -17.526 18.931 1.00 29.05 ? 24  ARG   B HG2  1 
ATOM   2653 H HG3  . ARG   B 1 44  ? 17.387 -16.149 18.624 1.00 29.05 ? 24  ARG   B HG3  1 
ATOM   2654 H HD2  . ARG   B 1 44  ? 14.601 -16.220 18.428 1.00 43.76 ? 24  ARG   B HD2  1 
ATOM   2655 H HD3  . ARG   B 1 44  ? 15.249 -16.102 19.875 1.00 43.76 ? 24  ARG   B HD3  1 
ATOM   2656 H HE   . ARG   B 1 44  ? 15.172 -14.136 18.054 1.00 63.88 ? 24  ARG   B HE   1 
ATOM   2657 H HH11 . ARG   B 1 44  ? 16.781 -15.039 20.811 1.00 42.61 ? 24  ARG   B HH11 1 
ATOM   2658 H HH12 . ARG   B 1 44  ? 17.297 -13.680 21.135 1.00 42.61 ? 24  ARG   B HH12 1 
ATOM   2659 H HH21 . ARG   B 1 44  ? 15.985 -12.104 18.563 1.00 52.22 ? 24  ARG   B HH21 1 
ATOM   2660 H HH22 . ARG   B 1 44  ? 16.819 -11.911 19.782 1.00 52.22 ? 24  ARG   B HH22 1 
ATOM   2661 N N    . LYS   B 1 45  ? 17.146 -20.041 17.295 1.00 17.04 ? 25  LYS   B N    1 
ATOM   2662 C CA   . LYS   B 1 45  ? 17.381 -21.201 18.135 1.00 15.72 ? 25  LYS   B CA   1 
ATOM   2663 C C    . LYS   B 1 45  ? 18.744 -21.824 17.851 1.00 14.34 ? 25  LYS   B C    1 
ATOM   2664 O O    . LYS   B 1 45  ? 19.413 -22.294 18.773 1.00 15.98 ? 25  LYS   B O    1 
ATOM   2665 C CB   . LYS   B 1 45  ? 16.266 -22.226 17.910 1.00 16.29 ? 25  LYS   B CB   1 
ATOM   2666 C CG   . LYS   B 1 45  ? 14.944 -21.836 18.562 1.00 22.55 ? 25  LYS   B CG   1 
ATOM   2667 C CD   . LYS   B 1 45  ? 15.068 -21.997 20.066 1.00 37.51 ? 25  LYS   B CD   1 
ATOM   2668 C CE   . LYS   B 1 45  ? 13.794 -21.671 20.825 1.00 54.09 ? 25  LYS   B CE   1 
ATOM   2669 N NZ   . LYS   B 1 45  ? 13.977 -22.006 22.273 1.00 59.66 ? 25  LYS   B NZ   1 
ATOM   2670 H H    . LYS   B 1 45  ? 16.475 -20.111 16.762 1.00 20.46 ? 25  LYS   B H    1 
ATOM   2671 H HA   . LYS   B 1 45  ? 17.366 -20.934 19.067 1.00 18.88 ? 25  LYS   B HA   1 
ATOM   2672 H HB2  . LYS   B 1 45  ? 16.112 -22.318 16.956 1.00 19.56 ? 25  LYS   B HB2  1 
ATOM   2673 H HB3  . LYS   B 1 45  ? 16.542 -23.077 18.284 1.00 19.56 ? 25  LYS   B HB3  1 
ATOM   2674 H HG2  . LYS   B 1 45  ? 14.736 -20.911 18.360 1.00 27.07 ? 25  LYS   B HG2  1 
ATOM   2675 H HG3  . LYS   B 1 45  ? 14.234 -22.414 18.240 1.00 27.07 ? 25  LYS   B HG3  1 
ATOM   2676 H HD2  . LYS   B 1 45  ? 15.302 -22.918 20.263 1.00 45.03 ? 25  LYS   B HD2  1 
ATOM   2677 H HD3  . LYS   B 1 45  ? 15.764 -21.403 20.387 1.00 45.03 ? 25  LYS   B HD3  1 
ATOM   2678 H HE2  . LYS   B 1 45  ? 13.596 -20.725 20.745 1.00 64.93 ? 25  LYS   B HE2  1 
ATOM   2679 H HE3  . LYS   B 1 45  ? 13.058 -22.195 20.473 1.00 64.93 ? 25  LYS   B HE3  1 
ATOM   2680 H HZ1  . LYS   B 1 45  ? 13.301 -21.677 22.750 1.00 71.60 ? 25  LYS   B HZ1  1 
ATOM   2681 H HZ2  . LYS   B 1 45  ? 14.003 -22.889 22.381 1.00 71.60 ? 25  LYS   B HZ2  1 
ATOM   2682 H HZ3  . LYS   B 1 45  ? 14.738 -21.656 22.573 1.00 71.60 ? 25  LYS   B HZ3  1 
ATOM   2683 N N    . ILE   B 1 46  ? 19.181 -21.821 16.589 1.00 13.82 ? 26  ILE   B N    1 
ATOM   2684 C CA   . ILE   B 1 46  ? 20.512 -22.325 16.269 1.00 14.40 ? 26  ILE   B CA   1 
ATOM   2685 C C    . ILE   B 1 46  ? 21.582 -21.448 16.902 1.00 14.05 ? 26  ILE   B C    1 
ATOM   2686 O O    . ILE   B 1 46  ? 22.567 -21.951 17.461 1.00 15.87 ? 26  ILE   B O    1 
ATOM   2687 C CB   . ILE   B 1 46  ? 20.711 -22.423 14.746 1.00 16.07 ? 26  ILE   B CB   1 
ATOM   2688 C CG1  . ILE   B 1 46  ? 19.636 -23.326 14.130 1.00 24.33 ? 26  ILE   B CG1  1 
ATOM   2689 C CG2  . ILE   B 1 46  ? 22.126 -22.926 14.443 1.00 15.22 ? 26  ILE   B CG2  1 
ATOM   2690 C CD1  . ILE   B 1 46  ? 19.698 -24.759 14.611 1.00 30.50 ? 26  ILE   B CD1  1 
ATOM   2691 H H    . ILE   B 1 46  ? 18.732 -21.537 15.912 1.00 16.60 ? 26  ILE   B H    1 
ATOM   2692 H HA   . ILE   B 1 46  ? 20.586 -23.219 16.639 1.00 17.30 ? 26  ILE   B HA   1 
ATOM   2693 H HB   . ILE   B 1 46  ? 20.613 -21.544 14.348 1.00 19.29 ? 26  ILE   B HB   1 
ATOM   2694 H HG12 . ILE   B 1 46  ? 18.763 -22.973 14.360 1.00 29.21 ? 26  ILE   B HG12 1 
ATOM   2695 H HG13 . ILE   B 1 46  ? 19.749 -23.331 13.166 1.00 29.21 ? 26  ILE   B HG13 1 
ATOM   2696 H HG21 . ILE   B 1 46  ? 22.167 -23.214 13.518 1.00 18.28 ? 26  ILE   B HG21 1 
ATOM   2697 H HG22 . ILE   B 1 46  ? 22.757 -22.205 14.594 1.00 18.28 ? 26  ILE   B HG22 1 
ATOM   2698 H HG23 . ILE   B 1 46  ? 22.329 -23.671 15.031 1.00 18.28 ? 26  ILE   B HG23 1 
ATOM   2699 H HD11 . ILE   B 1 46  ? 19.155 -25.312 14.027 1.00 36.61 ? 26  ILE   B HD11 1 
ATOM   2700 H HD12 . ILE   B 1 46  ? 20.620 -25.060 14.589 1.00 36.61 ? 26  ILE   B HD12 1 
ATOM   2701 H HD13 . ILE   B 1 46  ? 19.357 -24.802 15.518 1.00 36.61 ? 26  ILE   B HD13 1 
ATOM   2702 N N    . VAL   B 1 47  ? 21.417 -20.126 16.820 1.00 15.05 ? 27  VAL   B N    1 
ATOM   2703 C CA   . VAL   B 1 47  ? 22.404 -19.242 17.430 1.00 15.53 ? 27  VAL   B CA   1 
ATOM   2704 C C    . VAL   B 1 47  ? 22.484 -19.506 18.925 1.00 14.49 ? 27  VAL   B C    1 
ATOM   2705 O O    . VAL   B 1 47  ? 23.573 -19.602 19.501 1.00 14.52 ? 27  VAL   B O    1 
ATOM   2706 C CB   . VAL   B 1 47  ? 22.068 -17.772 17.141 1.00 13.49 ? 27  VAL   B CB   1 
ATOM   2707 C CG1  . VAL   B 1 47  ? 23.028 -16.860 17.896 1.00 15.29 ? 27  VAL   B CG1  1 
ATOM   2708 C CG2  . VAL   B 1 47  ? 22.133 -17.490 15.662 1.00 16.94 ? 27  VAL   B CG2  1 
ATOM   2709 H H    . VAL   B 1 47  ? 20.762 -19.730 16.427 1.00 18.07 ? 27  VAL   B H    1 
ATOM   2710 H HA   . VAL   B 1 47  ? 23.272 -19.431 17.039 1.00 18.64 ? 27  VAL   B HA   1 
ATOM   2711 H HB   . VAL   B 1 47  ? 21.164 -17.592 17.441 1.00 16.20 ? 27  VAL   B HB   1 
ATOM   2712 H HG11 . VAL   B 1 47  ? 22.901 -15.948 17.592 1.00 18.36 ? 27  VAL   B HG11 1 
ATOM   2713 H HG12 . VAL   B 1 47  ? 22.841 -16.922 18.845 1.00 18.36 ? 27  VAL   B HG12 1 
ATOM   2714 H HG13 . VAL   B 1 47  ? 23.939 -17.144 17.719 1.00 18.36 ? 27  VAL   B HG13 1 
ATOM   2715 H HG21 . VAL   B 1 47  ? 22.100 -16.531 15.521 1.00 20.34 ? 27  VAL   B HG21 1 
ATOM   2716 H HG22 . VAL   B 1 47  ? 22.962 -17.849 15.308 1.00 20.34 ? 27  VAL   B HG22 1 
ATOM   2717 H HG23 . VAL   B 1 47  ? 21.377 -17.914 15.226 1.00 20.34 ? 27  VAL   B HG23 1 
ATOM   2718 N N    . GLU   B 1 48  ? 21.324 -19.635 19.576 1.00 16.11 ? 28  GLU   B N    1 
ATOM   2719 C CA   . GLU   B 1 48  ? 21.307 -19.949 20.999 1.00 16.43 ? 28  GLU   B CA   1 
ATOM   2720 C C    . GLU   B 1 48  ? 22.046 -21.250 21.272 1.00 15.93 ? 28  GLU   B C    1 
ATOM   2721 O O    . GLU   B 1 48  ? 22.872 -21.323 22.183 1.00 16.00 ? 28  GLU   B O    1 
ATOM   2722 C CB   . GLU   B 1 48  ? 19.867 -20.014 21.503 1.00 15.63 ? 28  GLU   B CB   1 
ATOM   2723 C CG   . GLU   B 1 48  ? 19.175 -18.662 21.506 1.00 17.93 ? 28  GLU   B CG   1 
ATOM   2724 C CD   . GLU   B 1 48  ? 17.682 -18.738 21.773 1.00 47.75 ? 28  GLU   B CD   1 
ATOM   2725 O OE1  . GLU   B 1 48  ? 17.138 -19.855 21.896 1.00 40.57 ? 28  GLU   B OE1  1 
ATOM   2726 O OE2  . GLU   B 1 48  ? 17.053 -17.663 21.852 1.00 42.58 ? 28  GLU   B OE2  1 
ATOM   2727 H H    . GLU   B 1 48  ? 20.546 -19.546 19.219 1.00 19.34 ? 28  GLU   B H    1 
ATOM   2728 H HA   . GLU   B 1 48  ? 21.758 -19.241 21.487 1.00 19.72 ? 28  GLU   B HA   1 
ATOM   2729 H HB2  . GLU   B 1 48  ? 19.360 -20.609 20.929 1.00 18.77 ? 28  GLU   B HB2  1 
ATOM   2730 H HB3  . GLU   B 1 48  ? 19.868 -20.352 22.413 1.00 18.77 ? 28  GLU   B HB3  1 
ATOM   2731 H HG2  . GLU   B 1 48  ? 19.571 -18.110 22.199 1.00 21.53 ? 28  GLU   B HG2  1 
ATOM   2732 H HG3  . GLU   B 1 48  ? 19.299 -18.245 20.639 1.00 21.53 ? 28  GLU   B HG3  1 
ATOM   2733 N N    A GLN   B 1 49  ? 21.757 -22.289 20.484 0.53 14.06 ? 29  GLN   B N    1 
ATOM   2734 N N    B GLN   B 1 49  ? 21.775 -22.292 20.487 0.47 14.15 ? 29  GLN   B N    1 
ATOM   2735 C CA   A GLN   B 1 49  ? 22.436 -23.571 20.653 0.53 14.66 ? 29  GLN   B CA   1 
ATOM   2736 C CA   B GLN   B 1 49  ? 22.469 -23.550 20.738 0.47 14.71 ? 29  GLN   B CA   1 
ATOM   2737 C C    A GLN   B 1 49  ? 23.945 -23.414 20.515 0.53 14.91 ? 29  GLN   B C    1 
ATOM   2738 C C    B GLN   B 1 49  ? 23.971 -23.391 20.544 0.47 14.92 ? 29  GLN   B C    1 
ATOM   2739 O O    A GLN   B 1 49  ? 24.715 -23.907 21.346 0.53 16.26 ? 29  GLN   B O    1 
ATOM   2740 O O    B GLN   B 1 49  ? 24.765 -23.882 21.354 0.47 16.25 ? 29  GLN   B O    1 
ATOM   2741 C CB   A GLN   B 1 49  ? 21.904 -24.579 19.632 0.53 15.15 ? 29  GLN   B CB   1 
ATOM   2742 C CB   B GLN   B 1 49  ? 21.944 -24.670 19.843 0.47 16.09 ? 29  GLN   B CB   1 
ATOM   2743 C CG   A GLN   B 1 49  ? 20.512 -25.106 19.943 0.53 12.04 ? 29  GLN   B CG   1 
ATOM   2744 C CG   B GLN   B 1 49  ? 22.574 -26.009 20.225 0.47 20.32 ? 29  GLN   B CG   1 
ATOM   2745 C CD   A GLN   B 1 49  ? 20.058 -26.202 18.983 0.53 18.84 ? 29  GLN   B CD   1 
ATOM   2746 C CD   B GLN   B 1 49  ? 22.219 -27.144 19.287 0.47 26.10 ? 29  GLN   B CD   1 
ATOM   2747 O OE1  A GLN   B 1 49  ? 20.872 -26.894 18.375 0.53 17.72 ? 29  GLN   B OE1  1 
ATOM   2748 O OE1  B GLN   B 1 49  ? 21.107 -27.208 18.763 0.47 21.91 ? 29  GLN   B OE1  1 
ATOM   2749 N NE2  A GLN   B 1 49  ? 18.740 -26.367 18.861 0.53 15.39 ? 29  GLN   B NE2  1 
ATOM   2750 N NE2  B GLN   B 1 49  ? 23.169 -28.046 19.069 0.47 12.55 ? 29  GLN   B NE2  1 
ATOM   2751 H H    A GLN   B 1 49  ? 21.176 -22.276 19.850 0.53 16.89 ? 29  GLN   B H    1 
ATOM   2752 H H    B GLN   B 1 49  ? 21.219 -22.296 19.831 0.47 16.99 ? 29  GLN   B H    1 
ATOM   2753 H HA   A GLN   B 1 49  ? 22.249 -23.911 21.542 0.53 17.60 ? 29  GLN   B HA   1 
ATOM   2754 H HA   B GLN   B 1 49  ? 22.291 -23.808 21.656 0.47 17.66 ? 29  GLN   B HA   1 
ATOM   2755 H HB2  A GLN   B 1 49  ? 21.868 -24.151 18.762 0.53 18.19 ? 29  GLN   B HB2  1 
ATOM   2756 H HB2  B GLN   B 1 49  ? 20.982 -24.741 19.945 0.47 19.32 ? 29  GLN   B HB2  1 
ATOM   2757 H HB3  A GLN   B 1 49  ? 22.506 -25.339 19.603 0.53 18.19 ? 29  GLN   B HB3  1 
ATOM   2758 H HB3  B GLN   B 1 49  ? 22.166 -24.476 18.919 0.47 19.32 ? 29  GLN   B HB3  1 
ATOM   2759 H HG2  A GLN   B 1 49  ? 20.508 -25.475 20.840 0.53 14.46 ? 29  GLN   B HG2  1 
ATOM   2760 H HG2  B GLN   B 1 49  ? 23.539 -25.913 20.219 0.47 24.40 ? 29  GLN   B HG2  1 
ATOM   2761 H HG3  A GLN   B 1 49  ? 19.878 -24.375 19.882 0.53 14.46 ? 29  GLN   B HG3  1 
ATOM   2762 H HG3  B GLN   B 1 49  ? 22.270 -26.255 21.113 0.47 24.40 ? 29  GLN   B HG3  1 
ATOM   2763 H HE21 A GLN   B 1 49  ? 18.201 -25.870 19.310 0.53 18.48 ? 29  GLN   B HE21 1 
ATOM   2764 H HE21 B GLN   B 1 49  ? 23.935 -27.965 19.452 0.47 15.07 ? 29  GLN   B HE21 1 
ATOM   2765 H HE22 A GLN   B 1 49  ? 18.430 -26.971 18.333 0.53 18.48 ? 29  GLN   B HE22 1 
ATOM   2766 H HE22 B GLN   B 1 49  ? 23.019 -28.711 18.544 0.47 15.07 ? 29  GLN   B HE22 1 
ATOM   2767 N N    . TYR   B 1 50  ? 24.381 -22.715 19.470 1.00 14.60 ? 30  TYR   B N    1 
ATOM   2768 C CA   . TYR   B 1 50  ? 25.804 -22.521 19.231 1.00 14.42 ? 30  TYR   B CA   1 
ATOM   2769 C C    . TYR   B 1 50  ? 26.466 -21.826 20.408 1.00 13.73 ? 30  TYR   B C    1 
ATOM   2770 O O    . TYR   B 1 50  ? 27.497 -22.282 20.910 1.00 15.47 ? 30  TYR   B O    1 
ATOM   2771 C CB   . TYR   B 1 50  ? 25.989 -21.717 17.943 1.00 13.49 ? 30  TYR   B CB   1 
ATOM   2772 C CG   . TYR   B 1 50  ? 27.417 -21.526 17.496 1.00 13.49 ? 30  TYR   B CG   1 
ATOM   2773 C CD1  . TYR   B 1 50  ? 28.260 -20.642 18.155 1.00 15.05 ? 30  TYR   B CD1  1 
ATOM   2774 C CD2  . TYR   B 1 50  ? 27.916 -22.223 16.409 1.00 14.73 ? 30  TYR   B CD2  1 
ATOM   2775 C CE1  . TYR   B 1 50  ? 29.570 -20.461 17.753 1.00 13.15 ? 30  TYR   B CE1  1 
ATOM   2776 C CE2  . TYR   B 1 50  ? 29.214 -22.057 15.994 1.00 16.47 ? 30  TYR   B CE2  1 
ATOM   2777 C CZ   . TYR   B 1 50  ? 30.037 -21.180 16.650 1.00 15.74 ? 30  TYR   B CZ   1 
ATOM   2778 O OH   . TYR   B 1 50  ? 31.329 -21.032 16.210 1.00 17.69 ? 30  TYR   B OH   1 
ATOM   2779 H H    A TYR   B 1 50  ? 23.872 -22.343 18.885 0.53 17.53 ? 30  TYR   B H    1 
ATOM   2780 H H    B TYR   B 1 50  ? 23.864 -22.366 18.878 0.47 17.53 ? 30  TYR   B H    1 
ATOM   2781 H HA   . TYR   B 1 50  ? 26.236 -23.382 19.120 1.00 17.32 ? 30  TYR   B HA   1 
ATOM   2782 H HB2  . TYR   B 1 50  ? 25.522 -22.175 17.227 1.00 16.21 ? 30  TYR   B HB2  1 
ATOM   2783 H HB3  . TYR   B 1 50  ? 25.608 -20.835 18.076 1.00 16.21 ? 30  TYR   B HB3  1 
ATOM   2784 H HD1  . TYR   B 1 50  ? 27.937 -20.161 18.882 1.00 18.07 ? 30  TYR   B HD1  1 
ATOM   2785 H HD2  . TYR   B 1 50  ? 27.362 -22.814 15.951 1.00 17.69 ? 30  TYR   B HD2  1 
ATOM   2786 H HE1  . TYR   B 1 50  ? 30.129 -19.873 18.207 1.00 15.80 ? 30  TYR   B HE1  1 
ATOM   2787 H HE2  . TYR   B 1 50  ? 29.535 -22.540 15.267 1.00 19.78 ? 30  TYR   B HE2  1 
ATOM   2788 H HH   . TYR   B 1 50  ? 31.824 -20.794 16.846 1.00 21.24 ? 30  TYR   B HH   1 
ATOM   2789 N N    . MET   B 1 51  ? 25.883 -20.714 20.862 1.00 14.38 ? 31  MET   B N    1 
ATOM   2790 C CA   . MET   B 1 51  ? 26.514 -19.903 21.896 1.00 13.24 ? 31  MET   B CA   1 
ATOM   2791 C C    . MET   B 1 51  ? 26.552 -20.600 23.242 1.00 13.91 ? 31  MET   B C    1 
ATOM   2792 O O    . MET   B 1 51  ? 27.397 -20.266 24.075 1.00 16.20 ? 31  MET   B O    1 
ATOM   2793 C CB   . MET   B 1 51  ? 25.781 -18.560 22.026 1.00 12.90 ? 31  MET   B CB   1 
ATOM   2794 C CG   . MET   B 1 51  ? 25.784 -17.711 20.767 1.00 16.01 ? 31  MET   B CG   1 
ATOM   2795 S SD   . MET   B 1 51  ? 27.408 -17.405 20.049 1.00 15.38 ? 31  MET   B SD   1 
ATOM   2796 C CE   . MET   B 1 51  ? 28.305 -16.696 21.430 1.00 14.17 ? 31  MET   B CE   1 
ATOM   2797 H H    . MET   B 1 51  ? 25.126 -20.412 20.588 1.00 17.27 ? 31  MET   B H    1 
ATOM   2798 H HA   . MET   B 1 51  ? 27.426 -19.720 21.623 1.00 15.90 ? 31  MET   B HA   1 
ATOM   2799 H HB2  . MET   B 1 51  ? 24.855 -18.736 22.258 1.00 15.50 ? 31  MET   B HB2  1 
ATOM   2800 H HB3  . MET   B 1 51  ? 26.206 -18.043 22.728 1.00 15.50 ? 31  MET   B HB3  1 
ATOM   2801 H HG2  . MET   B 1 51  ? 25.250 -18.160 20.093 1.00 19.23 ? 31  MET   B HG2  1 
ATOM   2802 H HG3  . MET   B 1 51  ? 25.393 -16.848 20.978 1.00 19.23 ? 31  MET   B HG3  1 
ATOM   2803 H HE1  . MET   B 1 51  ? 29.198 -16.457 21.138 1.00 17.02 ? 31  MET   B HE1  1 
ATOM   2804 H HE2  . MET   B 1 51  ? 27.836 -15.905 21.740 1.00 17.02 ? 31  MET   B HE2  1 
ATOM   2805 H HE3  . MET   B 1 51  ? 28.355 -17.351 22.144 1.00 17.02 ? 31  MET   B HE3  1 
ATOM   2806 N N    . HIS   B 1 52  ? 25.672 -21.562 23.473 1.00 14.21 ? 32  HIS   B N    1 
ATOM   2807 C CA   . HIS   B 1 52  ? 25.682 -22.313 24.712 1.00 15.17 ? 32  HIS   B CA   1 
ATOM   2808 C C    . HIS   B 1 52  ? 26.341 -23.667 24.585 1.00 17.69 ? 32  HIS   B C    1 
ATOM   2809 O O    . HIS   B 1 52  ? 26.297 -24.456 25.535 1.00 18.77 ? 32  HIS   B O    1 
ATOM   2810 C CB   . HIS   B 1 52  ? 24.267 -22.453 25.215 1.00 16.25 ? 32  HIS   B CB   1 
ATOM   2811 C CG   . HIS   B 1 52  ? 23.756 -21.180 25.792 1.00 19.20 ? 32  HIS   B CG   1 
ATOM   2812 N ND1  . HIS   B 1 52  ? 24.031 -20.804 27.090 1.00 23.17 ? 32  HIS   B ND1  1 
ATOM   2813 C CD2  . HIS   B 1 52  ? 23.059 -20.161 25.239 1.00 20.78 ? 32  HIS   B CD2  1 
ATOM   2814 C CE1  . HIS   B 1 52  ? 23.483 -19.625 27.323 1.00 24.85 ? 32  HIS   B CE1  1 
ATOM   2815 N NE2  . HIS   B 1 52  ? 22.890 -19.212 26.217 1.00 19.89 ? 32  HIS   B NE2  1 
ATOM   2816 H H    . HIS   B 1 52  ? 25.056 -21.798 22.921 1.00 17.07 ? 32  HIS   B H    1 
ATOM   2817 H HA   . HIS   B 1 52  ? 26.194 -21.821 25.373 1.00 18.21 ? 32  HIS   B HA   1 
ATOM   2818 H HB2  . HIS   B 1 52  ? 23.690 -22.707 24.478 1.00 19.52 ? 32  HIS   B HB2  1 
ATOM   2819 H HB3  . HIS   B 1 52  ? 24.240 -23.133 25.906 1.00 19.52 ? 32  HIS   B HB3  1 
ATOM   2820 H HD1  . HIS   B 1 52  ? 24.486 -21.264 27.657 1.00 27.82 ? 32  HIS   B HD1  1 
ATOM   2821 H HD2  . HIS   B 1 52  ? 22.752 -20.113 24.362 1.00 24.95 ? 32  HIS   B HD2  1 
ATOM   2822 H HE1  . HIS   B 1 52  ? 23.510 -19.164 28.130 1.00 29.83 ? 32  HIS   B HE1  1 
ATOM   2823 N N    . THR   B 1 53  ? 26.989 -23.943 23.454 1.00 14.13 ? 33  THR   B N    1 
ATOM   2824 C CA   . THR   B 1 53  ? 27.707 -25.197 23.293 1.00 15.36 ? 33  THR   B CA   1 
ATOM   2825 C C    . THR   B 1 53  ? 29.019 -25.126 24.055 1.00 14.57 ? 33  THR   B C    1 
ATOM   2826 O O    . THR   B 1 53  ? 29.881 -24.290 23.760 1.00 15.63 ? 33  THR   B O    1 
ATOM   2827 C CB   . THR   B 1 53  ? 27.924 -25.493 21.815 1.00 14.70 ? 33  THR   B CB   1 
ATOM   2828 O OG1  . THR   B 1 53  ? 26.649 -25.665 21.189 1.00 17.17 ? 33  THR   B OG1  1 
ATOM   2829 C CG2  . THR   B 1 53  ? 28.738 -26.765 21.659 1.00 17.72 ? 33  THR   B CG2  1 
ATOM   2830 H H    . THR   B 1 53  ? 27.026 -23.421 22.772 1.00 16.97 ? 33  THR   B H    1 
ATOM   2831 H HA   . THR   B 1 53  ? 27.189 -25.929 23.665 1.00 18.45 ? 33  THR   B HA   1 
ATOM   2832 H HB   . THR   B 1 53  ? 28.403 -24.764 21.389 1.00 17.66 ? 33  THR   B HB   1 
ATOM   2833 H HG1  . THR   B 1 53  ? 26.313 -24.916 21.010 1.00 20.62 ? 33  THR   B HG1  1 
ATOM   2834 H HG21 . THR   B 1 53  ? 28.782 -27.017 20.723 1.00 21.28 ? 33  THR   B HG21 1 
ATOM   2835 H HG22 . THR   B 1 53  ? 29.638 -26.625 21.990 1.00 21.28 ? 33  THR   B HG22 1 
ATOM   2836 H HG23 . THR   B 1 53  ? 28.326 -27.486 22.160 1.00 21.28 ? 33  THR   B HG23 1 
ATOM   2837 N N    . ARG   B 1 54  ? 29.157 -26.012 25.042 1.00 15.01 ? 34  ARG   B N    1 
ATOM   2838 C CA   . ARG   B 1 54  ? 30.286 -26.044 25.946 1.00 16.25 ? 34  ARG   B CA   1 
ATOM   2839 C C    . ARG   B 1 54  ? 30.760 -27.475 26.119 1.00 17.59 ? 34  ARG   B C    1 
ATOM   2840 O O    . ARG   B 1 54  ? 30.016 -28.429 25.884 1.00 19.04 ? 34  ARG   B O    1 
ATOM   2841 C CB   . ARG   B 1 54  ? 29.919 -25.476 27.322 1.00 18.88 ? 34  ARG   B CB   1 
ATOM   2842 C CG   . ARG   B 1 54  ? 29.496 -24.041 27.295 1.00 20.64 ? 34  ARG   B CG   1 
ATOM   2843 C CD   . ARG   B 1 54  ? 28.959 -23.647 28.643 1.00 17.49 ? 34  ARG   B CD   1 
ATOM   2844 N NE   . ARG   B 1 54  ? 28.628 -22.236 28.688 1.00 20.49 ? 34  ARG   B NE   1 
ATOM   2845 C CZ   . ARG   B 1 54  ? 28.113 -21.631 29.750 1.00 22.92 ? 34  ARG   B CZ   1 
ATOM   2846 N NH1  . ARG   B 1 54  ? 27.887 -22.286 30.872 1.00 22.67 ? 34  ARG   B NH1  1 
ATOM   2847 N NH2  . ARG   B 1 54  ? 27.814 -20.341 29.676 1.00 26.67 ? 34  ARG   B NH2  1 
ATOM   2848 H H    . ARG   B 1 54  ? 28.580 -26.628 25.209 1.00 18.03 ? 34  ARG   B H    1 
ATOM   2849 H HA   . ARG   B 1 54  ? 31.007 -25.517 25.567 1.00 19.51 ? 34  ARG   B HA   1 
ATOM   2850 H HB2  . ARG   B 1 54  ? 29.185 -25.994 27.686 1.00 22.66 ? 34  ARG   B HB2  1 
ATOM   2851 H HB3  . ARG   B 1 54  ? 30.693 -25.544 27.903 1.00 22.66 ? 34  ARG   B HB3  1 
ATOM   2852 H HG2  . ARG   B 1 54  ? 30.257 -23.478 27.085 1.00 24.78 ? 34  ARG   B HG2  1 
ATOM   2853 H HG3  . ARG   B 1 54  ? 28.798 -23.917 26.633 1.00 24.78 ? 34  ARG   B HG3  1 
ATOM   2854 H HD2  . ARG   B 1 54  ? 28.155 -24.156 28.831 1.00 21.00 ? 34  ARG   B HD2  1 
ATOM   2855 H HD3  . ARG   B 1 54  ? 29.630 -23.825 29.321 1.00 21.00 ? 34  ARG   B HD3  1 
ATOM   2856 H HE   . ARG   B 1 54  ? 28.773 -21.764 27.985 1.00 24.60 ? 34  ARG   B HE   1 
ATOM   2857 H HH11 . ARG   B 1 54  ? 28.074 -23.124 30.926 1.00 27.21 ? 34  ARG   B HH11 1 
ATOM   2858 H HH12 . ARG   B 1 54  ? 27.553 -21.876 31.550 1.00 27.21 ? 34  ARG   B HH12 1 
ATOM   2859 H HH21 . ARG   B 1 54  ? 27.954 -19.909 28.947 1.00 32.02 ? 34  ARG   B HH21 1 
ATOM   2860 H HH22 . ARG   B 1 54  ? 27.480 -19.938 30.358 1.00 32.02 ? 34  ARG   B HH22 1 
ATOM   2861 N N    . GLY   B 1 55  ? 32.009 -27.609 26.548 1.00 18.48 ? 35  GLY   B N    1 
ATOM   2862 C CA   . GLY   B 1 55  ? 32.506 -28.919 26.920 1.00 19.36 ? 35  GLY   B CA   1 
ATOM   2863 C C    . GLY   B 1 55  ? 32.500 -29.880 25.754 1.00 19.36 ? 35  GLY   B C    1 
ATOM   2864 O O    . GLY   B 1 55  ? 32.722 -29.509 24.604 1.00 17.63 ? 35  GLY   B O    1 
ATOM   2865 H H    . GLY   B 1 55  ? 32.576 -26.967 26.630 1.00 22.19 ? 35  GLY   B H    1 
ATOM   2866 H HA2  . GLY   B 1 55  ? 33.416 -28.838 27.246 1.00 23.24 ? 35  GLY   B HA2  1 
ATOM   2867 H HA3  . GLY   B 1 55  ? 31.950 -29.287 27.624 1.00 23.24 ? 35  GLY   B HA3  1 
ATOM   2868 N N    . GLU   B 1 56  ? 32.228 -31.150 26.062 1.00 20.54 ? 36  GLU   B N    1 
ATOM   2869 C CA   . GLU   B 1 56  ? 32.318 -32.183 25.037 1.00 24.41 ? 36  GLU   B CA   1 
ATOM   2870 C C    . GLU   B 1 56  ? 31.333 -31.938 23.903 1.00 19.22 ? 36  GLU   B C    1 
ATOM   2871 O O    . GLU   B 1 56  ? 31.569 -32.383 22.772 1.00 19.00 ? 36  GLU   B O    1 
ATOM   2872 C CB   . GLU   B 1 56  ? 32.087 -33.563 25.654 1.00 27.29 ? 36  GLU   B CB   1 
ATOM   2873 C CG   . GLU   B 1 56  ? 33.108 -33.942 26.715 1.00 44.80 ? 36  GLU   B CG   1 
ATOM   2874 C CD   . GLU   B 1 56  ? 34.513 -34.084 26.159 1.00 55.09 ? 36  GLU   B CD   1 
ATOM   2875 O OE1  . GLU   B 1 56  ? 34.669 -34.653 25.057 1.00 50.35 ? 36  GLU   B OE1  1 
ATOM   2876 O OE2  . GLU   B 1 56  ? 35.463 -33.621 26.825 1.00 62.43 ? 36  GLU   B OE2  1 
ATOM   2877 H H    . GLU   B 1 56  ? 31.995 -31.432 26.840 1.00 24.66 ? 36  GLU   B H    1 
ATOM   2878 H HA   . GLU   B 1 56  ? 33.214 -32.169 24.663 1.00 29.31 ? 36  GLU   B HA   1 
ATOM   2879 H HB2  . GLU   B 1 56  ? 31.210 -33.576 26.069 1.00 32.76 ? 36  GLU   B HB2  1 
ATOM   2880 H HB3  . GLU   B 1 56  ? 32.130 -34.230 24.951 1.00 32.76 ? 36  GLU   B HB3  1 
ATOM   2881 H HG2  . GLU   B 1 56  ? 33.125 -33.253 27.397 1.00 53.78 ? 36  GLU   B HG2  1 
ATOM   2882 H HG3  . GLU   B 1 56  ? 32.854 -34.792 27.108 1.00 53.78 ? 36  GLU   B HG3  1 
ATOM   2883 N N    . ALA   B 1 57  ? 30.232 -31.221 24.171 1.00 19.00 ? 37  ALA   B N    1 
ATOM   2884 C CA   . ALA   B 1 57  ? 29.290 -30.891 23.108 1.00 17.36 ? 37  ALA   B CA   1 
ATOM   2885 C C    . ALA   B 1 57  ? 29.947 -30.099 21.990 1.00 17.07 ? 37  ALA   B C    1 
ATOM   2886 O O    . ALA   B 1 57  ? 29.435 -30.082 20.872 1.00 17.24 ? 37  ALA   B O    1 
ATOM   2887 C CB   . ALA   B 1 57  ? 28.109 -30.103 23.664 1.00 22.99 ? 37  ALA   B CB   1 
ATOM   2888 H H    . ALA   B 1 57  ? 30.016 -30.922 24.948 1.00 22.82 ? 37  ALA   B H    1 
ATOM   2889 H HA   . ALA   B 1 57  ? 28.947 -31.719 22.738 1.00 20.85 ? 37  ALA   B HA   1 
ATOM   2890 H HB1  . ALA   B 1 57  ? 27.511 -29.874 22.936 1.00 27.60 ? 37  ALA   B HB1  1 
ATOM   2891 H HB2  . ALA   B 1 57  ? 27.643 -30.650 24.315 1.00 27.60 ? 37  ALA   B HB2  1 
ATOM   2892 H HB3  . ALA   B 1 57  ? 28.440 -29.295 24.087 1.00 27.60 ? 37  ALA   B HB3  1 
ATOM   2893 N N    . ARG   B 1 58  ? 31.060 -29.424 22.269 1.00 17.49 ? 38  ARG   B N    1 
ATOM   2894 C CA   . ARG   B 1 58  ? 31.758 -28.688 21.227 1.00 15.29 ? 38  ARG   B CA   1 
ATOM   2895 C C    . ARG   B 1 58  ? 32.226 -29.606 20.112 1.00 16.26 ? 38  ARG   B C    1 
ATOM   2896 O O    . ARG   B 1 58  ? 32.418 -29.147 18.986 1.00 17.97 ? 38  ARG   B O    1 
ATOM   2897 C CB   . ARG   B 1 58  ? 32.927 -27.922 21.818 1.00 17.17 ? 38  ARG   B CB   1 
ATOM   2898 C CG   . ARG   B 1 58  ? 32.470 -26.773 22.710 1.00 15.57 ? 38  ARG   B CG   1 
ATOM   2899 C CD   . ARG   B 1 58  ? 33.531 -26.372 23.703 1.00 19.31 ? 38  ARG   B CD   1 
ATOM   2900 N NE   . ARG   B 1 58  ? 34.752 -25.906 23.066 1.00 19.21 ? 38  ARG   B NE   1 
ATOM   2901 C CZ   . ARG   B 1 58  ? 35.852 -25.578 23.726 1.00 14.96 ? 38  ARG   B CZ   1 
ATOM   2902 N NH1  . ARG   B 1 58  ? 35.903 -25.629 25.044 1.00 17.25 ? 38  ARG   B NH1  1 
ATOM   2903 N NH2  . ARG   B 1 58  ? 36.926 -25.195 23.045 1.00 18.92 ? 38  ARG   B NH2  1 
ATOM   2904 H H    . ARG   B 1 58  ? 31.426 -29.379 23.046 1.00 21.00 ? 38  ARG   B H    1 
ATOM   2905 H HA   . ARG   B 1 58  ? 31.156 -28.034 20.839 1.00 18.37 ? 38  ARG   B HA   1 
ATOM   2906 H HB2  . ARG   B 1 58  ? 33.465 -28.525 22.354 1.00 20.62 ? 38  ARG   B HB2  1 
ATOM   2907 H HB3  . ARG   B 1 58  ? 33.462 -27.552 21.098 1.00 20.62 ? 38  ARG   B HB3  1 
ATOM   2908 H HG2  . ARG   B 1 58  ? 32.265 -26.002 22.158 1.00 18.69 ? 38  ARG   B HG2  1 
ATOM   2909 H HG3  . ARG   B 1 58  ? 31.681 -27.046 23.204 1.00 18.69 ? 38  ARG   B HG3  1 
ATOM   2910 H HD2  . ARG   B 1 58  ? 33.190 -25.654 24.258 1.00 23.19 ? 38  ARG   B HD2  1 
ATOM   2911 H HD3  . ARG   B 1 58  ? 33.754 -27.139 24.253 1.00 23.19 ? 38  ARG   B HD3  1 
ATOM   2912 H HE   . ARG   B 1 58  ? 34.760 -25.840 22.209 1.00 23.06 ? 38  ARG   B HE   1 
ATOM   2913 H HH11 . ARG   B 1 58  ? 35.213 -25.880 25.491 1.00 20.71 ? 38  ARG   B HH11 1 
ATOM   2914 H HH12 . ARG   B 1 58  ? 36.626 -25.412 25.455 1.00 20.71 ? 38  ARG   B HH12 1 
ATOM   2915 H HH21 . ARG   B 1 58  ? 36.902 -25.163 22.186 1.00 22.72 ? 38  ARG   B HH21 1 
ATOM   2916 H HH22 . ARG   B 1 58  ? 37.646 -24.979 23.464 1.00 22.72 ? 38  ARG   B HH22 1 
ATOM   2917 N N    . LEU   B 1 59  ? 32.403 -30.895 20.402 1.00 16.10 ? 39  LEU   B N    1 
ATOM   2918 C CA   . LEU   B 1 59  ? 32.788 -31.824 19.353 1.00 19.40 ? 39  LEU   B CA   1 
ATOM   2919 C C    . LEU   B 1 59  ? 31.699 -32.015 18.309 1.00 18.72 ? 39  LEU   B C    1 
ATOM   2920 O O    . LEU   B 1 59  ? 31.980 -32.571 17.246 1.00 18.84 ? 39  LEU   B O    1 
ATOM   2921 C CB   . LEU   B 1 59  ? 33.145 -33.172 19.971 1.00 19.43 ? 39  LEU   B CB   1 
ATOM   2922 C CG   . LEU   B 1 59  ? 34.406 -33.132 20.841 1.00 21.58 ? 39  LEU   B CG   1 
ATOM   2923 C CD1  . LEU   B 1 59  ? 34.613 -34.482 21.499 1.00 34.98 ? 39  LEU   B CD1  1 
ATOM   2924 C CD2  . LEU   B 1 59  ? 35.616 -32.718 20.025 1.00 28.48 ? 39  LEU   B CD2  1 
ATOM   2925 H H    . LEU   B 1 59  ? 32.308 -31.245 21.181 1.00 19.33 ? 39  LEU   B H    1 
ATOM   2926 H HA   . LEU   B 1 59  ? 33.570 -31.472 18.899 1.00 23.30 ? 39  LEU   B HA   1 
ATOM   2927 H HB2  . LEU   B 1 59  ? 32.408 -33.465 20.528 1.00 23.33 ? 39  LEU   B HB2  1 
ATOM   2928 H HB3  . LEU   B 1 59  ? 33.296 -33.812 19.257 1.00 23.33 ? 39  LEU   B HB3  1 
ATOM   2929 H HG   . LEU   B 1 59  ? 34.299 -32.467 21.539 1.00 25.91 ? 39  LEU   B HG   1 
ATOM   2930 H HD11 . LEU   B 1 59  ? 35.401 -34.441 22.063 1.00 41.99 ? 39  LEU   B HD11 1 
ATOM   2931 H HD12 . LEU   B 1 59  ? 33.833 -34.695 22.036 1.00 41.99 ? 39  LEU   B HD12 1 
ATOM   2932 H HD13 . LEU   B 1 59  ? 34.733 -35.155 20.810 1.00 41.99 ? 39  LEU   B HD13 1 
ATOM   2933 H HD21 . LEU   B 1 59  ? 36.421 -32.947 20.516 1.00 34.19 ? 39  LEU   B HD21 1 
ATOM   2934 H HD22 . LEU   B 1 59  ? 35.601 -33.187 19.176 1.00 34.19 ? 39  LEU   B HD22 1 
ATOM   2935 H HD23 . LEU   B 1 59  ? 35.583 -31.760 19.874 1.00 34.19 ? 39  LEU   B HD23 1 
ATOM   2936 N N    . LYS   B 1 60  ? 30.467 -31.578 18.578 1.00 17.21 ? 40  LYS   B N    1 
ATOM   2937 C CA   . LYS   B 1 60  ? 29.389 -31.728 17.611 1.00 17.95 ? 40  LYS   B CA   1 
ATOM   2938 C C    . LYS   B 1 60  ? 28.811 -30.400 17.144 1.00 17.68 ? 40  LYS   B C    1 
ATOM   2939 O O    . LYS   B 1 60  ? 27.819 -30.396 16.406 1.00 18.12 ? 40  LYS   B O    1 
ATOM   2940 C CB   . LYS   B 1 60  ? 28.282 -32.609 18.194 1.00 21.62 ? 40  LYS   B CB   1 
ATOM   2941 C CG   . LYS   B 1 60  ? 28.729 -34.039 18.420 1.00 30.41 ? 40  LYS   B CG   1 
ATOM   2942 C CD   . LYS   B 1 60  ? 27.593 -34.894 18.938 1.00 33.49 ? 40  LYS   B CD   1 
ATOM   2943 H H    . LYS   B 1 60  ? 30.236 -31.194 19.312 1.00 20.67 ? 40  LYS   B H    1 
ATOM   2944 H HA   . LYS   B 1 60  ? 29.746 -32.169 16.825 1.00 21.55 ? 40  LYS   B HA   1 
ATOM   2945 H HB2  . LYS   B 1 60  ? 28.004 -32.243 19.048 1.00 25.96 ? 40  LYS   B HB2  1 
ATOM   2946 H HB3  . LYS   B 1 60  ? 27.532 -32.623 17.579 1.00 25.96 ? 40  LYS   B HB3  1 
ATOM   2947 H HG2  . LYS   B 1 60  ? 29.038 -34.416 17.581 1.00 36.50 ? 40  LYS   B HG2  1 
ATOM   2948 H HG3  . LYS   B 1 60  ? 29.445 -34.053 19.073 1.00 36.50 ? 40  LYS   B HG3  1 
ATOM   2949 N N    . ARG   B 1 61  ? 29.427 -29.277 17.517 1.00 16.35 ? 41  ARG   B N    1 
ATOM   2950 C CA   . ARG   B 1 61  ? 28.907 -27.981 17.106 1.00 16.81 ? 41  ARG   B CA   1 
ATOM   2951 C C    . ARG   B 1 61  ? 28.925 -27.828 15.596 1.00 17.89 ? 41  ARG   B C    1 
ATOM   2952 O O    . ARG   B 1 61  ? 28.077 -27.129 15.033 1.00 15.95 ? 41  ARG   B O    1 
ATOM   2953 C CB   . ARG   B 1 61  ? 29.716 -26.870 17.773 1.00 16.07 ? 41  ARG   B CB   1 
ATOM   2954 C CG   . ARG   B 1 61  ? 29.064 -25.504 17.708 1.00 14.87 ? 41  ARG   B CG   1 
ATOM   2955 C CD   . ARG   B 1 61  ? 29.906 -24.474 18.435 1.00 16.37 ? 41  ARG   B CD   1 
ATOM   2956 N NE   . ARG   B 1 61  ? 31.158 -24.210 17.739 1.00 16.07 ? 41  ARG   B NE   1 
ATOM   2957 C CZ   . ARG   B 1 61  ? 32.195 -23.575 18.264 1.00 17.23 ? 41  ARG   B CZ   1 
ATOM   2958 N NH1  . ARG   B 1 61  ? 32.160 -23.092 19.491 1.00 17.41 ? 41  ARG   B NH1  1 
ATOM   2959 N NH2  . ARG   B 1 61  ? 33.300 -23.427 17.541 1.00 20.42 ? 41  ARG   B NH2  1 
ATOM   2960 H H    . ARG   B 1 61  ? 30.137 -29.242 18.000 1.00 19.63 ? 41  ARG   B H    1 
ATOM   2961 H HA   . ARG   B 1 61  ? 27.985 -27.898 17.398 1.00 20.18 ? 41  ARG   B HA   1 
ATOM   2962 H HB2  . ARG   B 1 61  ? 29.838 -27.094 18.708 1.00 19.30 ? 41  ARG   B HB2  1 
ATOM   2963 H HB3  . ARG   B 1 61  ? 30.578 -26.807 17.331 1.00 19.30 ? 41  ARG   B HB3  1 
ATOM   2964 H HG2  . ARG   B 1 61  ? 28.974 -25.231 16.782 1.00 17.86 ? 41  ARG   B HG2  1 
ATOM   2965 H HG3  . ARG   B 1 61  ? 28.191 -25.541 18.129 1.00 17.86 ? 41  ARG   B HG3  1 
ATOM   2966 H HD2  . ARG   B 1 61  ? 29.411 -23.642 18.497 1.00 19.66 ? 41  ARG   B HD2  1 
ATOM   2967 H HD3  . ARG   B 1 61  ? 30.116 -24.802 19.323 1.00 19.66 ? 41  ARG   B HD3  1 
ATOM   2968 H HE   . ARG   B 1 61  ? 31.229 -24.486 16.927 1.00 19.29 ? 41  ARG   B HE   1 
ATOM   2969 H HH11 . ARG   B 1 61  ? 31.451 -23.186 19.970 1.00 20.90 ? 41  ARG   B HH11 1 
ATOM   2970 H HH12 . ARG   B 1 61  ? 32.845 -22.683 19.813 1.00 20.90 ? 41  ARG   B HH12 1 
ATOM   2971 H HH21 . ARG   B 1 61  ? 33.336 -23.742 16.741 1.00 24.52 ? 41  ARG   B HH21 1 
ATOM   2972 H HH22 . ARG   B 1 61  ? 33.979 -23.017 17.872 1.00 24.52 ? 41  ARG   B HH22 1 
ATOM   2973 N N    . HIS   B 1 62  ? 29.872 -28.482 14.925 1.00 15.87 ? 42  HIS   B N    1 
ATOM   2974 C CA   . HIS   B 1 62  ? 29.962 -28.389 13.479 1.00 16.82 ? 42  HIS   B CA   1 
ATOM   2975 C C    . HIS   B 1 62  ? 28.721 -28.934 12.788 1.00 15.83 ? 42  HIS   B C    1 
ATOM   2976 O O    . HIS   B 1 62  ? 28.471 -28.586 11.629 1.00 16.67 ? 42  HIS   B O    1 
ATOM   2977 C CB   . HIS   B 1 62  ? 31.203 -29.130 12.987 1.00 17.19 ? 42  HIS   B CB   1 
ATOM   2978 C CG   . HIS   B 1 62  ? 31.136 -30.612 13.178 1.00 17.73 ? 42  HIS   B CG   1 
ATOM   2979 N ND1  . HIS   B 1 62  ? 31.261 -31.208 14.415 1.00 16.37 ? 42  HIS   B ND1  1 
ATOM   2980 C CD2  . HIS   B 1 62  ? 30.948 -31.619 12.289 1.00 20.61 ? 42  HIS   B CD2  1 
ATOM   2981 C CE1  . HIS   B 1 62  ? 31.159 -32.520 14.279 1.00 20.72 ? 42  HIS   B CE1  1 
ATOM   2982 N NE2  . HIS   B 1 62  ? 30.965 -32.795 13.001 1.00 19.74 ? 42  HIS   B NE2  1 
ATOM   2983 H H    . HIS   B 1 62  ? 30.470 -28.983 15.286 1.00 19.06 ? 42  HIS   B H    1 
ATOM   2984 H HA   . HIS   B 1 62  ? 30.051 -27.456 13.231 1.00 20.19 ? 42  HIS   B HA   1 
ATOM   2985 H HB2  . HIS   B 1 62  ? 31.313 -28.958 12.039 1.00 20.64 ? 42  HIS   B HB2  1 
ATOM   2986 H HB3  . HIS   B 1 62  ? 31.975 -28.804 13.475 1.00 20.64 ? 42  HIS   B HB3  1 
ATOM   2987 H HD2  . HIS   B 1 62  ? 30.830 -31.530 11.371 1.00 24.74 ? 42  HIS   B HD2  1 
ATOM   2988 H HE1  . HIS   B 1 62  ? 31.213 -33.143 14.967 1.00 24.88 ? 42  HIS   B HE1  1 
ATOM   2989 H HE2  . HIS   B 1 62  ? 30.867 -33.582 12.668 1.00 23.70 ? 42  HIS   B HE2  1 
ATOM   2990 N N    . LEU   B 1 63  ? 27.948 -29.784 13.461 1.00 16.94 ? 43  LEU   B N    1 
ATOM   2991 C CA   . LEU   B 1 63  ? 26.737 -30.306 12.848 1.00 17.69 ? 43  LEU   B CA   1 
ATOM   2992 C C    . LEU   B 1 63  ? 25.687 -29.222 12.658 1.00 19.43 ? 43  LEU   B C    1 
ATOM   2993 O O    . LEU   B 1 63  ? 24.695 -29.457 11.959 1.00 22.25 ? 43  LEU   B O    1 
ATOM   2994 C CB   . LEU   B 1 63  ? 26.174 -31.448 13.690 1.00 19.99 ? 43  LEU   B CB   1 
ATOM   2995 C CG   . LEU   B 1 63  ? 27.129 -32.637 13.785 1.00 23.44 ? 43  LEU   B CG   1 
ATOM   2996 C CD1  . LEU   B 1 63  ? 26.510 -33.700 14.687 1.00 27.43 ? 43  LEU   B CD1  1 
ATOM   2997 C CD2  . LEU   B 1 63  ? 27.485 -33.217 12.430 1.00 24.89 ? 43  LEU   B CD2  1 
ATOM   2998 H H    . LEU   B 1 63  ? 28.103 -30.066 14.259 1.00 20.34 ? 43  LEU   B H    1 
ATOM   2999 H HA   . LEU   B 1 63  ? 26.950 -30.672 11.976 1.00 21.24 ? 43  LEU   B HA   1 
ATOM   3000 H HB2  . LEU   B 1 63  ? 26.006 -31.125 14.589 1.00 24.01 ? 43  LEU   B HB2  1 
ATOM   3001 H HB3  . LEU   B 1 63  ? 25.347 -31.758 13.289 1.00 24.01 ? 43  LEU   B HB3  1 
ATOM   3002 H HG   . LEU   B 1 63  ? 27.967 -32.330 14.166 1.00 28.14 ? 43  LEU   B HG   1 
ATOM   3003 H HD11 . LEU   B 1 63  ? 27.119 -34.452 14.752 1.00 32.92 ? 43  LEU   B HD11 1 
ATOM   3004 H HD12 . LEU   B 1 63  ? 26.359 -33.319 15.566 1.00 32.92 ? 43  LEU   B HD12 1 
ATOM   3005 H HD13 . LEU   B 1 63  ? 25.668 -33.988 14.303 1.00 32.92 ? 43  LEU   B HD13 1 
ATOM   3006 H HD21 . LEU   B 1 63  ? 28.004 -34.027 12.560 1.00 29.88 ? 43  LEU   B HD21 1 
ATOM   3007 H HD22 . LEU   B 1 63  ? 26.668 -33.422 11.950 1.00 29.88 ? 43  LEU   B HD22 1 
ATOM   3008 H HD23 . LEU   B 1 63  ? 28.007 -32.567 11.935 1.00 29.88 ? 43  LEU   B HD23 1 
ATOM   3009 N N    . LEU   B 1 64  ? 25.893 -28.039 13.239 1.00 16.40 ? 44  LEU   B N    1 
ATOM   3010 C CA   . LEU   B 1 64  ? 24.998 -26.917 13.008 1.00 17.32 ? 44  LEU   B CA   1 
ATOM   3011 C C    . LEU   B 1 64  ? 25.264 -26.211 11.689 1.00 16.60 ? 44  LEU   B C    1 
ATOM   3012 O O    . LEU   B 1 64  ? 24.531 -25.278 11.356 1.00 18.70 ? 44  LEU   B O    1 
ATOM   3013 C CB   . LEU   B 1 64  ? 25.121 -25.911 14.148 1.00 15.61 ? 44  LEU   B CB   1 
ATOM   3014 C CG   . LEU   B 1 64  ? 24.730 -26.442 15.514 1.00 17.69 ? 44  LEU   B CG   1 
ATOM   3015 C CD1  . LEU   B 1 64  ? 24.924 -25.375 16.569 1.00 17.80 ? 44  LEU   B CD1  1 
ATOM   3016 C CD2  . LEU   B 1 64  ? 23.283 -26.928 15.493 1.00 18.13 ? 44  LEU   B CD2  1 
ATOM   3017 H H    . LEU   B 1 64  ? 26.546 -27.865 13.770 1.00 19.69 ? 44  LEU   B H    1 
ATOM   3018 H HA   . LEU   B 1 64  ? 24.087 -27.249 12.993 1.00 20.79 ? 44  LEU   B HA   1 
ATOM   3019 H HB2  . LEU   B 1 64  ? 26.044 -25.619 14.201 1.00 18.74 ? 44  LEU   B HB2  1 
ATOM   3020 H HB3  . LEU   B 1 64  ? 24.545 -25.155 13.953 1.00 18.74 ? 44  LEU   B HB3  1 
ATOM   3021 H HG   . LEU   B 1 64  ? 25.298 -27.194 15.743 1.00 21.24 ? 44  LEU   B HG   1 
ATOM   3022 H HD11 . LEU   B 1 64  ? 24.800 -25.772 17.446 1.00 21.38 ? 44  LEU   B HD11 1 
ATOM   3023 H HD12 . LEU   B 1 64  ? 25.821 -25.015 16.493 1.00 21.38 ? 44  LEU   B HD12 1 
ATOM   3024 H HD13 . LEU   B 1 64  ? 24.272 -24.671 16.430 1.00 21.38 ? 44  LEU   B HD13 1 
ATOM   3025 H HD21 . LEU   B 1 64  ? 23.026 -27.191 16.390 1.00 21.77 ? 44  LEU   B HD21 1 
ATOM   3026 H HD22 . LEU   B 1 64  ? 22.713 -26.207 15.184 1.00 21.77 ? 44  LEU   B HD22 1 
ATOM   3027 H HD23 . LEU   B 1 64  ? 23.213 -27.686 14.892 1.00 21.77 ? 44  LEU   B HD23 1 
ATOM   3028 N N    . PHE   B 1 65  ? 26.283 -26.626 10.944 1.00 15.81 ? 45  PHE   B N    1 
ATOM   3029 C CA   . PHE   B 1 65  ? 26.688 -25.963 9.719  1.00 14.39 ? 45  PHE   B CA   1 
ATOM   3030 C C    . PHE   B 1 65  ? 26.197 -26.720 8.491  1.00 19.10 ? 45  PHE   B C    1 
ATOM   3031 O O    . PHE   B 1 65  ? 25.977 -27.924 8.532  1.00 20.13 ? 45  PHE   B O    1 
ATOM   3032 C CB   . PHE   B 1 65  ? 28.215 -25.856 9.637  1.00 17.07 ? 45  PHE   B CB   1 
ATOM   3033 C CG   . PHE   B 1 65  ? 28.817 -24.830 10.544 1.00 15.27 ? 45  PHE   B CG   1 
ATOM   3034 C CD1  . PHE   B 1 65  ? 28.947 -25.076 11.892 1.00 16.52 ? 45  PHE   B CD1  1 
ATOM   3035 C CD2  . PHE   B 1 65  ? 29.277 -23.638 10.031 1.00 15.13 ? 45  PHE   B CD2  1 
ATOM   3036 C CE1  . PHE   B 1 65  ? 29.513 -24.130 12.729 1.00 18.14 ? 45  PHE   B CE1  1 
ATOM   3037 C CE2  . PHE   B 1 65  ? 29.853 -22.687 10.856 1.00 14.92 ? 45  PHE   B CE2  1 
ATOM   3038 C CZ   . PHE   B 1 65  ? 29.966 -22.941 12.198 1.00 16.38 ? 45  PHE   B CZ   1 
ATOM   3039 H H    . PHE   B 1 65  ? 26.767 -27.311 11.136 1.00 18.99 ? 45  PHE   B H    1 
ATOM   3040 H HA   . PHE   B 1 65  ? 26.301 -25.074 9.716  1.00 17.28 ? 45  PHE   B HA   1 
ATOM   3041 H HB2  . PHE   B 1 65  ? 28.598 -26.715 9.874  1.00 20.49 ? 45  PHE   B HB2  1 
ATOM   3042 H HB3  . PHE   B 1 65  ? 28.460 -25.622 8.728  1.00 20.49 ? 45  PHE   B HB3  1 
ATOM   3043 H HD1  . PHE   B 1 65  ? 28.652 -25.885 12.244 1.00 19.84 ? 45  PHE   B HD1  1 
ATOM   3044 H HD2  . PHE   B 1 65  ? 29.200 -23.469 9.120  1.00 18.17 ? 45  PHE   B HD2  1 
ATOM   3045 H HE1  . PHE   B 1 65  ? 29.587 -24.295 13.641 1.00 21.78 ? 45  PHE   B HE1  1 
ATOM   3046 H HE2  . PHE   B 1 65  ? 30.161 -21.884 10.503 1.00 17.91 ? 45  PHE   B HE2  1 
ATOM   3047 H HZ   . PHE   B 1 65  ? 30.352 -22.305 12.756 1.00 19.67 ? 45  PHE   B HZ   1 
ATOM   3048 N N    . THR   B 1 66  ? 26.065 -25.995 7.388  1.00 18.73 ? 46  THR   B N    1 
ATOM   3049 C CA   . THR   B 1 66  ? 25.896 -26.639 6.091  1.00 18.12 ? 46  THR   B CA   1 
ATOM   3050 C C    . THR   B 1 66  ? 27.148 -27.444 5.752  1.00 20.69 ? 46  THR   B C    1 
ATOM   3051 O O    . THR   B 1 66  ? 28.232 -27.219 6.294  1.00 18.26 ? 46  THR   B O    1 
ATOM   3052 C CB   . THR   B 1 66  ? 25.632 -25.610 4.997  1.00 20.44 ? 46  THR   B CB   1 
ATOM   3053 O OG1  . THR   B 1 66  ? 26.753 -24.742 4.879  1.00 20.45 ? 46  THR   B OG1  1 
ATOM   3054 C CG2  . THR   B 1 66  ? 24.376 -24.805 5.306  1.00 23.91 ? 46  THR   B CG2  1 
ATOM   3055 H H    . THR   B 1 66  ? 26.070 -25.135 7.362  1.00 22.49 ? 46  THR   B H    1 
ATOM   3056 H HA   . THR   B 1 66  ? 25.130 -27.234 6.123  1.00 21.76 ? 46  THR   B HA   1 
ATOM   3057 H HB   . THR   B 1 66  ? 25.492 -26.063 4.151  1.00 24.54 ? 46  THR   B HB   1 
ATOM   3058 H HG1  . THR   B 1 66  ? 27.453 -25.191 4.755  1.00 24.55 ? 46  THR   B HG1  1 
ATOM   3059 H HG21 . THR   B 1 66  ? 24.151 -24.239 4.551  1.00 28.70 ? 46  THR   B HG21 1 
ATOM   3060 H HG22 . THR   B 1 66  ? 23.633 -25.404 5.482  1.00 28.70 ? 46  THR   B HG22 1 
ATOM   3061 H HG23 . THR   B 1 66  ? 24.523 -24.247 6.085  1.00 28.70 ? 46  THR   B HG23 1 
ATOM   3062 N N    . GLU   B 1 67  ? 26.998 -28.387 4.817  1.00 22.20 ? 47  GLU   B N    1 
ATOM   3063 C CA   . GLU   B 1 67  ? 28.125 -29.240 4.456  1.00 22.21 ? 47  GLU   B CA   1 
ATOM   3064 C C    . GLU   B 1 67  ? 29.330 -28.414 4.038  1.00 18.77 ? 47  GLU   B C    1 
ATOM   3065 O O    . GLU   B 1 67  ? 30.472 -28.787 4.315  1.00 20.78 ? 47  GLU   B O    1 
ATOM   3066 C CB   . GLU   B 1 67  ? 27.732 -30.198 3.324  1.00 20.63 ? 47  GLU   B CB   1 
ATOM   3067 C CG   . GLU   B 1 67  ? 28.845 -31.173 2.973  1.00 42.43 ? 47  GLU   B CG   1 
ATOM   3068 C CD   . GLU   B 1 67  ? 28.469 -32.140 1.868  1.00 62.39 ? 47  GLU   B CD   1 
ATOM   3069 O OE1  . GLU   B 1 67  ? 27.325 -32.074 1.372  1.00 41.86 ? 47  GLU   B OE1  1 
ATOM   3070 O OE2  . GLU   B 1 67  ? 29.325 -32.968 1.497  1.00 50.68 ? 47  GLU   B OE2  1 
ATOM   3071 H H    . GLU   B 1 67  ? 26.270 -28.548 4.388  1.00 26.65 ? 47  GLU   B H    1 
ATOM   3072 H HA   . GLU   B 1 67  ? 28.366 -29.770 5.233  1.00 26.66 ? 47  GLU   B HA   1 
ATOM   3073 H HB2  . GLU   B 1 67  ? 26.956 -30.712 3.599  1.00 24.76 ? 47  GLU   B HB2  1 
ATOM   3074 H HB3  . GLU   B 1 67  ? 27.522 -29.681 2.531  1.00 24.76 ? 47  GLU   B HB3  1 
ATOM   3075 H HG2  . GLU   B 1 67  ? 29.621 -30.671 2.678  1.00 50.93 ? 47  GLU   B HG2  1 
ATOM   3076 H HG3  . GLU   B 1 67  ? 29.066 -31.694 3.761  1.00 50.93 ? 47  GLU   B HG3  1 
ATOM   3077 N N    . ASP   B 1 68  ? 29.094 -27.298 3.356  1.00 20.84 ? 48  ASP   B N    1 
ATOM   3078 C CA   . ASP   B 1 68  ? 30.149 -26.418 2.883  1.00 17.67 ? 48  ASP   B CA   1 
ATOM   3079 C C    . ASP   B 1 68  ? 30.282 -25.169 3.748  1.00 22.39 ? 48  ASP   B C    1 
ATOM   3080 O O    . ASP   B 1 68  ? 30.831 -24.159 3.294  1.00 22.53 ? 48  ASP   B O    1 
ATOM   3081 C CB   . ASP   B 1 68  ? 29.888 -26.017 1.433  1.00 26.20 ? 48  ASP   B CB   1 
ATOM   3082 C CG   . ASP   B 1 68  ? 28.617 -25.215 1.272  1.00 43.57 ? 48  ASP   B CG   1 
ATOM   3083 O OD1  . ASP   B 1 68  ? 27.821 -25.144 2.234  1.00 35.41 ? 48  ASP   B OD1  1 
ATOM   3084 O OD2  . ASP   B 1 68  ? 28.419 -24.644 0.183  1.00 51.01 ? 48  ASP   B OD2  1 
ATOM   3085 H H    . ASP   B 1 68  ? 28.305 -27.024 3.149  1.00 25.02 ? 48  ASP   B H    1 
ATOM   3086 H HA   . ASP   B 1 68  ? 30.989 -26.901 2.916  1.00 21.22 ? 48  ASP   B HA   1 
ATOM   3087 H HB2  . ASP   B 1 68  ? 30.627 -25.475 1.117  1.00 31.46 ? 48  ASP   B HB2  1 
ATOM   3088 H HB3  . ASP   B 1 68  ? 29.808 -26.818 0.893  1.00 31.46 ? 48  ASP   B HB3  1 
ATOM   3089 N N    . GLY   B 1 69  ? 29.786 -25.224 4.976  1.00 19.96 ? 49  GLY   B N    1 
ATOM   3090 C CA   . GLY   B 1 69  ? 29.821 -24.064 5.837  1.00 19.15 ? 49  GLY   B CA   1 
ATOM   3091 C C    . GLY   B 1 69  ? 31.229 -23.669 6.223  1.00 19.52 ? 49  GLY   B C    1 
ATOM   3092 O O    . GLY   B 1 69  ? 32.168 -24.467 6.230  1.00 19.51 ? 49  GLY   B O    1 
ATOM   3093 H H    . GLY   B 1 69  ? 29.425 -25.920 5.330  1.00 23.96 ? 49  GLY   B H    1 
ATOM   3094 H HA2  . GLY   B 1 69  ? 29.408 -23.314 5.381  1.00 23.00 ? 49  GLY   B HA2  1 
ATOM   3095 H HA3  . GLY   B 1 69  ? 29.324 -24.252 6.648  1.00 23.00 ? 49  GLY   B HA3  1 
ATOM   3096 N N    . VAL   B 1 70  ? 31.360 -22.392 6.569  1.00 16.26 ? 50  VAL   B N    1 
ATOM   3097 C CA   . VAL   B 1 70  ? 32.626 -21.778 6.932  1.00 17.68 ? 50  VAL   B CA   1 
ATOM   3098 C C    . VAL   B 1 70  ? 32.492 -21.193 8.328  1.00 15.48 ? 50  VAL   B C    1 
ATOM   3099 O O    . VAL   B 1 70  ? 31.482 -20.567 8.656  1.00 16.75 ? 50  VAL   B O    1 
ATOM   3100 C CB   . VAL   B 1 70  ? 33.023 -20.679 5.930  1.00 19.03 ? 50  VAL   B CB   1 
ATOM   3101 C CG1  . VAL   B 1 70  ? 34.230 -19.912 6.437  1.00 27.17 ? 50  VAL   B CG1  1 
ATOM   3102 C CG2  . VAL   B 1 70  ? 33.295 -21.281 4.559  1.00 22.54 ? 50  VAL   B CG2  1 
ATOM   3103 H H    . VAL   B 1 70  ? 30.700 -21.841 6.601  1.00 19.53 ? 50  VAL   B H    1 
ATOM   3104 H HA   . VAL   B 1 70  ? 33.320 -22.456 6.942  1.00 21.23 ? 50  VAL   B HA   1 
ATOM   3105 H HB   . VAL   B 1 70  ? 32.289 -20.052 5.839  1.00 22.85 ? 50  VAL   B HB   1 
ATOM   3106 H HG11 . VAL   B 1 70  ? 34.643 -19.447 5.694  1.00 32.62 ? 50  VAL   B HG11 1 
ATOM   3107 H HG12 . VAL   B 1 70  ? 33.939 -19.274 7.107  1.00 32.62 ? 50  VAL   B HG12 1 
ATOM   3108 H HG13 . VAL   B 1 70  ? 34.860 -20.538 6.828  1.00 32.62 ? 50  VAL   B HG13 1 
ATOM   3109 H HG21 . VAL   B 1 70  ? 33.569 -20.575 3.953  1.00 27.06 ? 50  VAL   B HG21 1 
ATOM   3110 H HG22 . VAL   B 1 70  ? 34.000 -21.942 4.638  1.00 27.06 ? 50  VAL   B HG22 1 
ATOM   3111 H HG23 . VAL   B 1 70  ? 32.484 -21.700 4.232  1.00 27.06 ? 50  VAL   B HG23 1 
ATOM   3112 N N    . GLY   B 1 71  ? 33.507 -21.403 9.142  1.00 15.48 ? 51  GLY   B N    1 
ATOM   3113 C CA   . GLY   B 1 71  ? 33.592 -20.738 10.425 1.00 13.69 ? 51  GLY   B CA   1 
ATOM   3114 C C    . GLY   B 1 71  ? 35.010 -20.264 10.626 1.00 18.88 ? 51  GLY   B C    1 
ATOM   3115 O O    . GLY   B 1 71  ? 35.961 -20.883 10.163 1.00 21.49 ? 51  GLY   B O    1 
ATOM   3116 H H    . GLY   B 1 71  ? 34.166 -21.930 8.974  1.00 18.59 ? 51  GLY   B H    1 
ATOM   3117 H HA2  . GLY   B 1 71  ? 32.992 -19.976 10.449 1.00 16.44 ? 51  GLY   B HA2  1 
ATOM   3118 H HA3  . GLY   B 1 71  ? 33.353 -21.350 11.138 1.00 16.44 ? 51  GLY   B HA3  1 
ATOM   3119 N N    . GLY   B 1 72  ? 35.149 -19.142 11.289 1.00 17.84 ? 52  GLY   B N    1 
ATOM   3120 C CA   . GLY   B 1 72  ? 36.508 -18.695 11.489 1.00 22.43 ? 52  GLY   B CA   1 
ATOM   3121 C C    . GLY   B 1 72  ? 36.607 -17.395 12.240 1.00 17.66 ? 52  GLY   B C    1 
ATOM   3122 O O    . GLY   B 1 72  ? 35.617 -16.801 12.677 1.00 17.43 ? 52  GLY   B O    1 
ATOM   3123 H H    . GLY   B 1 72  ? 34.519 -18.654 11.612 1.00 21.42 ? 52  GLY   B H    1 
ATOM   3124 H HA2  . GLY   B 1 72  ? 36.994 -19.368 11.991 1.00 26.92 ? 52  GLY   B HA2  1 
ATOM   3125 H HA3  . GLY   B 1 72  ? 36.933 -18.576 10.626 1.00 26.92 ? 52  GLY   B HA3  1 
ATOM   3126 N N    . LEU   B 1 73  ? 37.855 -16.980 12.367 1.00 14.76 ? 53  LEU   B N    1 
ATOM   3127 C CA   . LEU   B 1 73  ? 38.254 -15.810 13.125 1.00 13.45 ? 53  LEU   B CA   1 
ATOM   3128 C C    . LEU   B 1 73  ? 38.635 -14.730 12.131 1.00 16.09 ? 53  LEU   B C    1 
ATOM   3129 O O    . LEU   B 1 73  ? 39.546 -14.922 11.326 1.00 16.04 ? 53  LEU   B O    1 
ATOM   3130 C CB   . LEU   B 1 73  ? 39.428 -16.152 14.032 1.00 16.76 ? 53  LEU   B CB   1 
ATOM   3131 C CG   . LEU   B 1 73  ? 40.060 -15.009 14.807 1.00 18.42 ? 53  LEU   B CG   1 
ATOM   3132 C CD1  . LEU   B 1 73  ? 39.041 -14.370 15.705 1.00 18.07 ? 53  LEU   B CD1  1 
ATOM   3133 C CD2  . LEU   B 1 73  ? 41.233 -15.585 15.577 1.00 18.01 ? 53  LEU   B CD2  1 
ATOM   3134 H H    . LEU   B 1 73  ? 38.523 -17.381 12.003 1.00 17.72 ? 53  LEU   B H    1 
ATOM   3135 H HA   . LEU   B 1 73  ? 37.525 -15.486 13.676 1.00 16.15 ? 53  LEU   B HA   1 
ATOM   3136 H HB2  . LEU   B 1 73  ? 39.120 -16.799 14.686 1.00 20.12 ? 53  LEU   B HB2  1 
ATOM   3137 H HB3  . LEU   B 1 73  ? 40.126 -16.541 13.483 1.00 20.12 ? 53  LEU   B HB3  1 
ATOM   3138 H HG   . LEU   B 1 73  ? 40.382 -14.304 14.223 1.00 22.12 ? 53  LEU   B HG   1 
ATOM   3139 H HD11 . LEU   B 1 73  ? 39.499 -13.824 16.363 1.00 21.70 ? 53  LEU   B HD11 1 
ATOM   3140 H HD12 . LEU   B 1 73  ? 38.450 -13.818 15.169 1.00 21.70 ? 53  LEU   B HD12 1 
ATOM   3141 H HD13 . LEU   B 1 73  ? 38.531 -15.066 16.149 1.00 21.70 ? 53  LEU   B HD13 1 
ATOM   3142 H HD21 . LEU   B 1 73  ? 41.642 -14.880 16.104 1.00 21.62 ? 53  LEU   B HD21 1 
ATOM   3143 H HD22 . LEU   B 1 73  ? 40.912 -16.290 16.161 1.00 21.62 ? 53  LEU   B HD22 1 
ATOM   3144 H HD23 . LEU   B 1 73  ? 41.878 -15.944 14.948 1.00 21.62 ? 53  LEU   B HD23 1 
ATOM   3145 N N    . TRP   B 1 74  ? 37.932 -13.602 12.183 1.00 14.01 ? 54  TRP   B N    1 
ATOM   3146 C CA   . TRP   B 1 74  ? 38.096 -12.550 11.196 1.00 15.26 ? 54  TRP   B CA   1 
ATOM   3147 C C    . TRP   B 1 74  ? 39.050 -11.449 11.633 1.00 18.78 ? 54  TRP   B C    1 
ATOM   3148 O O    . TRP   B 1 74  ? 39.397 -10.594 10.812 1.00 21.35 ? 54  TRP   B O    1 
ATOM   3149 C CB   . TRP   B 1 74  ? 36.719 -11.962 10.850 1.00 14.73 ? 54  TRP   B CB   1 
ATOM   3150 C CG   . TRP   B 1 74  ? 36.260 -12.401 9.498  1.00 14.26 ? 54  TRP   B CG   1 
ATOM   3151 C CD1  . TRP   B 1 74  ? 36.036 -11.604 8.412  1.00 16.61 ? 54  TRP   B CD1  1 
ATOM   3152 C CD2  . TRP   B 1 74  ? 36.015 -13.747 9.064  1.00 16.10 ? 54  TRP   B CD2  1 
ATOM   3153 N NE1  . TRP   B 1 74  ? 35.656 -12.369 7.338  1.00 21.16 ? 54  TRP   B NE1  1 
ATOM   3154 C CE2  . TRP   B 1 74  ? 35.636 -13.685 7.709  1.00 15.07 ? 54  TRP   B CE2  1 
ATOM   3155 C CE3  . TRP   B 1 74  ? 36.073 -14.990 9.692  1.00 16.77 ? 54  TRP   B CE3  1 
ATOM   3156 C CZ2  . TRP   B 1 74  ? 35.312 -14.821 6.972  1.00 20.01 ? 54  TRP   B CZ2  1 
ATOM   3157 C CZ3  . TRP   B 1 74  ? 35.754 -16.123 8.960  1.00 22.34 ? 54  TRP   B CZ3  1 
ATOM   3158 C CH2  . TRP   B 1 74  ? 35.380 -16.029 7.616  1.00 19.32 ? 54  TRP   B CH2  1 
ATOM   3159 H H    . TRP   B 1 74  ? 37.348 -13.424 12.788 1.00 16.83 ? 54  TRP   B H    1 
ATOM   3160 H HA   . TRP   B 1 74  ? 38.471 -12.928 10.385 1.00 18.32 ? 54  TRP   B HA   1 
ATOM   3161 H HB2  . TRP   B 1 74  ? 36.069 -12.261 11.505 1.00 17.69 ? 54  TRP   B HB2  1 
ATOM   3162 H HB3  . TRP   B 1 74  ? 36.774 -10.994 10.854 1.00 17.69 ? 54  TRP   B HB3  1 
ATOM   3163 H HD1  . TRP   B 1 74  ? 36.128 -10.679 8.402  1.00 19.95 ? 54  TRP   B HD1  1 
ATOM   3164 H HE1  . TRP   B 1 74  ? 35.462 -12.068 6.557  1.00 25.40 ? 54  TRP   B HE1  1 
ATOM   3165 H HE3  . TRP   B 1 74  ? 36.321 -15.058 10.585 1.00 20.13 ? 54  TRP   B HE3  1 
ATOM   3166 H HZ2  . TRP   B 1 74  ? 35.060 -14.763 6.078  1.00 24.02 ? 54  TRP   B HZ2  1 
ATOM   3167 H HZ3  . TRP   B 1 74  ? 35.790 -16.958 9.369  1.00 26.82 ? 54  TRP   B HZ3  1 
ATOM   3168 H HH2  . TRP   B 1 74  ? 35.171 -16.805 7.148  1.00 23.19 ? 54  TRP   B HH2  1 
ATOM   3169 N N    . THR   B 1 75  ? 39.521 -11.480 12.878 1.00 15.16 ? 55  THR   B N    1 
ATOM   3170 C CA   . THR   B 1 75  ? 40.376 -10.446 13.445 1.00 15.25 ? 55  THR   B CA   1 
ATOM   3171 C C    . THR   B 1 75  ? 41.636 -11.140 13.942 1.00 16.29 ? 55  THR   B C    1 
ATOM   3172 O O    . THR   B 1 75  ? 41.631 -11.755 15.009 1.00 18.46 ? 55  THR   B O    1 
ATOM   3173 C CB   . THR   B 1 75  ? 39.653 -9.721  14.560 1.00 14.34 ? 55  THR   B CB   1 
ATOM   3174 O OG1  . THR   B 1 75  ? 39.101 -10.691 15.448 1.00 14.83 ? 55  THR   B OG1  1 
ATOM   3175 C CG2  . THR   B 1 75  ? 38.545 -8.870  13.997 1.00 15.27 ? 55  THR   B CG2  1 
ATOM   3176 H H    . THR   B 1 75  ? 39.352 -12.115 13.432 1.00 18.20 ? 55  THR   B H    1 
ATOM   3177 H HA   . THR   B 1 75  ? 40.624 -9.795  12.769 1.00 18.32 ? 55  THR   B HA   1 
ATOM   3178 H HB   . THR   B 1 75  ? 40.266 -9.142  15.040 1.00 17.22 ? 55  THR   B HB   1 
ATOM   3179 H HG1  . THR   B 1 75  ? 39.717 -11.090 15.856 1.00 17.81 ? 55  THR   B HG1  1 
ATOM   3180 H HG21 . THR   B 1 75  ? 38.014 -8.497  14.718 1.00 18.33 ? 55  THR   B HG21 1 
ATOM   3181 H HG22 . THR   B 1 75  ? 38.918 -8.143  13.473 1.00 18.33 ? 55  THR   B HG22 1 
ATOM   3182 H HG23 . THR   B 1 75  ? 37.972 -9.406  13.427 1.00 18.33 ? 55  THR   B HG23 1 
ATOM   3183 N N    . THR   B 1 76  ? 42.704 -11.067 13.156 1.00 15.17 ? 56  THR   B N    1 
ATOM   3184 C CA   . THR   B 1 76  ? 43.934 -11.774 13.476 1.00 16.87 ? 56  THR   B CA   1 
ATOM   3185 C C    . THR   B 1 76  ? 45.109 -10.839 13.243 1.00 17.04 ? 56  THR   B C    1 
ATOM   3186 O O    . THR   B 1 76  ? 44.959 -9.747  12.700 1.00 17.14 ? 56  THR   B O    1 
ATOM   3187 C CB   . THR   B 1 76  ? 44.130 -13.037 12.619 1.00 19.18 ? 56  THR   B CB   1 
ATOM   3188 O OG1  . THR   B 1 76  ? 44.583 -12.651 11.323 1.00 22.19 ? 56  THR   B OG1  1 
ATOM   3189 C CG2  . THR   B 1 76  ? 42.836 -13.827 12.489 1.00 21.67 ? 56  THR   B CG2  1 
ATOM   3190 H H    . THR   B 1 76  ? 42.739 -10.610 12.428 1.00 18.22 ? 56  THR   B H    1 
ATOM   3191 H HA   . THR   B 1 76  ? 43.896 -12.037 14.409 1.00 20.25 ? 56  THR   B HA   1 
ATOM   3192 H HB   . THR   B 1 76  ? 44.782 -13.616 13.044 1.00 23.03 ? 56  THR   B HB   1 
ATOM   3193 H HG1  . THR   B 1 76  ? 44.092 -12.042 11.017 1.00 26.64 ? 56  THR   B HG1  1 
ATOM   3194 H HG21 . THR   B 1 76  ? 43.022 -14.714 12.142 1.00 26.02 ? 56  THR   B HG21 1 
ATOM   3195 H HG22 . THR   B 1 76  ? 42.410 -13.912 13.356 1.00 26.02 ? 56  THR   B HG22 1 
ATOM   3196 H HG23 . THR   B 1 76  ? 42.229 -13.373 11.884 1.00 26.02 ? 56  THR   B HG23 1 
ATOM   3197 N N    . ASP   B 1 77  ? 46.304 -11.298 13.619 1.00 15.48 ? 57  ASP   B N    1 
ATOM   3198 C CA   . ASP   B 1 77  ? 47.475 -10.447 13.452 1.00 16.49 ? 57  ASP   B CA   1 
ATOM   3199 C C    . ASP   B 1 77  ? 47.812 -10.217 11.985 1.00 20.61 ? 57  ASP   B C    1 
ATOM   3200 O O    . ASP   B 1 77  ? 48.459 -9.215  11.658 1.00 23.56 ? 57  ASP   B O    1 
ATOM   3201 C CB   . ASP   B 1 77  ? 48.675 -11.027 14.203 1.00 18.53 ? 57  ASP   B CB   1 
ATOM   3202 C CG   . ASP   B 1 77  ? 49.169 -12.341 13.631 1.00 23.74 ? 57  ASP   B CG   1 
ATOM   3203 O OD1  . ASP   B 1 77  ? 49.752 -12.336 12.524 1.00 30.70 ? 57  ASP   B OD1  1 
ATOM   3204 O OD2  . ASP   B 1 77  ? 48.998 -13.374 14.299 1.00 22.91 ? 57  ASP   B OD2  1 
ATOM   3205 H H    . ASP   B 1 77  ? 46.455 -12.072 13.961 1.00 18.58 ? 57  ASP   B H    1 
ATOM   3206 H HA   . ASP   B 1 77  ? 47.290 -9.581  13.848 1.00 19.80 ? 57  ASP   B HA   1 
ATOM   3207 H HB2  . ASP   B 1 77  ? 49.407 -10.392 14.162 1.00 22.25 ? 57  ASP   B HB2  1 
ATOM   3208 H HB3  . ASP   B 1 77  ? 48.421 -11.182 15.126 1.00 22.25 ? 57  ASP   B HB3  1 
ATOM   3209 N N    . SER   B 1 78  ? 47.367 -11.095 11.086 1.00 19.62 ? 58  SER   B N    1 
ATOM   3210 C CA   . SER   B 1 78  ? 47.704 -10.922 9.679  1.00 21.98 ? 58  SER   B CA   1 
ATOM   3211 C C    . SER   B 1 78  ? 46.815 -9.911  8.972  1.00 26.31 ? 58  SER   B C    1 
ATOM   3212 O O    . SER   B 1 78  ? 47.173 -9.447  7.886  1.00 27.20 ? 58  SER   B O    1 
ATOM   3213 C CB   . SER   B 1 78  ? 47.605 -12.250 8.929  1.00 27.50 ? 58  SER   B CB   1 
ATOM   3214 O OG   . SER   B 1 78  ? 46.249 -12.623 8.782  1.00 24.90 ? 58  SER   B OG   1 
ATOM   3215 H H    . SER   B 1 78  ? 46.880 -11.781 11.263 1.00 23.56 ? 58  SER   B H    1 
ATOM   3216 H HA   . SER   B 1 78  ? 48.622 -10.613 9.638  1.00 26.39 ? 58  SER   B HA   1 
ATOM   3217 H HB2  . SER   B 1 78  ? 48.005 -12.152 8.051  1.00 33.01 ? 58  SER   B HB2  1 
ATOM   3218 H HB3  . SER   B 1 78  ? 48.072 -12.936 9.431  1.00 33.01 ? 58  SER   B HB3  1 
ATOM   3219 H HG   . SER   B 1 78  ? 45.939 -12.875 9.521  1.00 29.89 ? 58  SER   B HG   1 
ATOM   3220 N N    . GLY   B 1 79  ? 45.662 -9.576  9.542  1.00 19.59 ? 59  GLY   B N    1 
ATOM   3221 C CA   . GLY   B 1 79  ? 44.684 -8.773  8.855  1.00 23.36 ? 59  GLY   B CA   1 
ATOM   3222 C C    . GLY   B 1 79  ? 43.762 -9.555  7.946  1.00 22.06 ? 59  GLY   B C    1 
ATOM   3223 O O    . GLY   B 1 79  ? 42.803 -8.978  7.415  1.00 25.06 ? 59  GLY   B O    1 
ATOM   3224 H H    . GLY   B 1 79  ? 45.429 -9.809  10.336 1.00 23.52 ? 59  GLY   B H    1 
ATOM   3225 H HA2  . GLY   B 1 79  ? 44.137 -8.317  9.513  1.00 28.04 ? 59  GLY   B HA2  1 
ATOM   3226 H HA3  . GLY   B 1 79  ? 45.146 -8.113  8.315  1.00 28.04 ? 59  GLY   B HA3  1 
ATOM   3227 N N    . GLN   B 1 80  ? 44.020 -10.846 7.756  1.00 22.93 ? 60  GLN   B N    1 
ATOM   3228 C CA   . GLN   B 1 80  ? 43.181 -11.727 6.973  1.00 22.67 ? 60  GLN   B CA   1 
ATOM   3229 C C    . GLN   B 1 80  ? 42.454 -12.708 7.884  1.00 18.61 ? 60  GLN   B C    1 
ATOM   3230 O O    . GLN   B 1 80  ? 42.965 -13.067 8.950  1.00 23.05 ? 60  GLN   B O    1 
ATOM   3231 C CB   . GLN   B 1 80  ? 44.008 -12.517 5.955  1.00 25.36 ? 60  GLN   B CB   1 
ATOM   3232 C CG   . GLN   B 1 80  ? 44.638 -11.641 4.898  1.00 35.13 ? 60  GLN   B CG   1 
ATOM   3233 C CD   . GLN   B 1 80  ? 43.603 -10.873 4.104  1.00 38.51 ? 60  GLN   B CD   1 
ATOM   3234 O OE1  . GLN   B 1 80  ? 42.608 -11.439 3.648  1.00 43.91 ? 60  GLN   B OE1  1 
ATOM   3235 N NE2  . GLN   B 1 80  ? 43.824 -9.576  3.944  1.00 43.31 ? 60  GLN   B NE2  1 
ATOM   3236 H H    . GLN   B 1 80  ? 44.705 -11.246 8.088  1.00 27.53 ? 60  GLN   B H    1 
ATOM   3237 H HA   . GLN   B 1 80  ? 42.525 -11.204 6.486  1.00 27.22 ? 60  GLN   B HA   1 
ATOM   3238 H HB2  . GLN   B 1 80  ? 44.720 -12.981 6.422  1.00 30.45 ? 60  GLN   B HB2  1 
ATOM   3239 H HB3  . GLN   B 1 80  ? 43.431 -13.156 5.509  1.00 30.45 ? 60  GLN   B HB3  1 
ATOM   3240 H HG2  . GLN   B 1 80  ? 45.228 -11.001 5.325  1.00 42.16 ? 60  GLN   B HG2  1 
ATOM   3241 H HG3  . GLN   B 1 80  ? 45.140 -12.197 4.282  1.00 42.16 ? 60  GLN   B HG3  1 
ATOM   3242 H HE21 . GLN   B 1 80  ? 44.526 -9.214  4.283  1.00 51.98 ? 60  GLN   B HE21 1 
ATOM   3243 H HE22 . GLN   B 1 80  ? 43.264 -9.096  3.500  1.00 51.98 ? 60  GLN   B HE22 1 
ATOM   3244 N N    . PRO   B 1 81  ? 41.262 -13.159 7.498  1.00 20.81 ? 61  PRO   B N    1 
ATOM   3245 C CA   . PRO   B 1 81  ? 40.581 -14.170 8.304  1.00 17.34 ? 61  PRO   B CA   1 
ATOM   3246 C C    . PRO   B 1 81  ? 41.359 -15.471 8.311  1.00 19.91 ? 61  PRO   B C    1 
ATOM   3247 O O    . PRO   B 1 81  ? 42.080 -15.800 7.364  1.00 22.09 ? 61  PRO   B O    1 
ATOM   3248 C CB   . PRO   B 1 81  ? 39.224 -14.336 7.613  1.00 20.51 ? 61  PRO   B CB   1 
ATOM   3249 C CG   . PRO   B 1 81  ? 39.057 -13.134 6.742  1.00 25.74 ? 61  PRO   B CG   1 
ATOM   3250 C CD   . PRO   B 1 81  ? 40.460 -12.751 6.328  1.00 22.88 ? 61  PRO   B CD   1 
ATOM   3251 H HA   . PRO   B 1 81  ? 40.441 -13.858 9.212  1.00 20.83 ? 61  PRO   B HA   1 
ATOM   3252 H HB2  . PRO   B 1 81  ? 39.225 -15.148 7.082  1.00 24.62 ? 61  PRO   B HB2  1 
ATOM   3253 H HB3  . PRO   B 1 81  ? 38.521 -14.377 8.280  1.00 24.62 ? 61  PRO   B HB3  1 
ATOM   3254 H HG2  . PRO   B 1 81  ? 38.518 -13.360 5.968  1.00 30.91 ? 61  PRO   B HG2  1 
ATOM   3255 H HG3  . PRO   B 1 81  ? 38.636 -12.418 7.243  1.00 30.91 ? 61  PRO   B HG3  1 
ATOM   3256 H HD2  . PRO   B 1 81  ? 40.733 -13.234 5.533  1.00 27.47 ? 61  PRO   B HD2  1 
ATOM   3257 H HD3  . PRO   B 1 81  ? 40.529 -11.795 6.175  1.00 27.47 ? 61  PRO   B HD3  1 
ATOM   3258 N N    . ILE   B 1 82  ? 41.221 -16.198 9.404  1.00 15.99 ? 62  ILE   B N    1 
ATOM   3259 C CA   . ILE   B 1 82  ? 41.634 -17.591 9.497  1.00 16.89 ? 62  ILE   B CA   1 
ATOM   3260 C C    . ILE   B 1 82  ? 40.335 -18.378 9.562  1.00 21.17 ? 62  ILE   B C    1 
ATOM   3261 O O    . ILE   B 1 82  ? 39.623 -18.344 10.576 1.00 22.03 ? 62  ILE   B O    1 
ATOM   3262 C CB   . ILE   B 1 82  ? 42.534 -17.852 10.707 1.00 23.97 ? 62  ILE   B CB   1 
ATOM   3263 C CG1  . ILE   B 1 82  ? 43.773 -16.954 10.597 1.00 24.20 ? 62  ILE   B CG1  1 
ATOM   3264 C CG2  . ILE   B 1 82  ? 42.937 -19.308 10.751 1.00 31.73 ? 62  ILE   B CG2  1 
ATOM   3265 C CD1  . ILE   B 1 82  ? 44.622 -16.921 11.834 1.00 31.80 ? 62  ILE   B CD1  1 
ATOM   3266 H H    . ILE   B 1 82  ? 40.879 -15.898 10.133 1.00 19.20 ? 62  ILE   B H    1 
ATOM   3267 H HA   . ILE   B 1 82  ? 42.141 -17.860 8.715  1.00 20.28 ? 62  ILE   B HA   1 
ATOM   3268 H HB   . ILE   B 1 82  ? 42.055 -17.646 11.524 1.00 28.78 ? 62  ILE   B HB   1 
ATOM   3269 H HG12 . ILE   B 1 82  ? 44.327 -17.277 9.869  1.00 29.06 ? 62  ILE   B HG12 1 
ATOM   3270 H HG13 . ILE   B 1 82  ? 43.483 -16.046 10.416 1.00 29.06 ? 62  ILE   B HG13 1 
ATOM   3271 H HG21 . ILE   B 1 82  ? 43.506 -19.455 11.522 1.00 38.09 ? 62  ILE   B HG21 1 
ATOM   3272 H HG22 . ILE   B 1 82  ? 42.139 -19.854 10.819 1.00 38.09 ? 62  ILE   B HG22 1 
ATOM   3273 H HG23 . ILE   B 1 82  ? 43.419 -19.527 9.938  1.00 38.09 ? 62  ILE   B HG23 1 
ATOM   3274 H HD11 . ILE   B 1 82  ? 45.323 -16.261 11.718 1.00 38.17 ? 62  ILE   B HD11 1 
ATOM   3275 H HD12 . ILE   B 1 82  ? 44.066 -16.683 12.592 1.00 38.17 ? 62  ILE   B HD12 1 
ATOM   3276 H HD13 . ILE   B 1 82  ? 45.013 -17.798 11.972 1.00 38.17 ? 62  ILE   B HD13 1 
ATOM   3277 N N    . ALA   B 1 83  ? 39.985 -19.017 8.457  1.00 24.58 ? 63  ALA   B N    1 
ATOM   3278 C CA   . ALA   B 1 83  ? 38.689 -19.651 8.288  1.00 24.82 ? 63  ALA   B CA   1 
ATOM   3279 C C    . ALA   B 1 83  ? 38.884 -21.139 8.054  1.00 29.34 ? 63  ALA   B C    1 
ATOM   3280 O O    . ALA   B 1 83  ? 39.898 -21.570 7.496  1.00 28.73 ? 63  ALA   B O    1 
ATOM   3281 C CB   . ALA   B 1 83  ? 37.918 -19.025 7.122  1.00 30.48 ? 63  ALA   B CB   1 
ATOM   3282 H H    . ALA   B 1 83  ? 40.497 -19.100 7.770  1.00 29.51 ? 63  ALA   B H    1 
ATOM   3283 H HA   . ALA   B 1 83  ? 38.155 -19.538 9.090  1.00 29.80 ? 63  ALA   B HA   1 
ATOM   3284 H HB1  . ALA   B 1 83  ? 37.062 -19.472 7.033  1.00 36.59 ? 63  ALA   B HB1  1 
ATOM   3285 H HB2  . ALA   B 1 83  ? 37.782 -18.082 7.303  1.00 36.59 ? 63  ALA   B HB2  1 
ATOM   3286 H HB3  . ALA   B 1 83  ? 38.434 -19.134 6.308  1.00 36.59 ? 63  ALA   B HB3  1 
ATOM   3287 N N    . ILE   B 1 84  ? 37.912 -21.917 8.512  1.00 19.93 ? 64  ILE   B N    1 
ATOM   3288 C CA   . ILE   B 1 84  ? 37.850 -23.354 8.276  1.00 18.76 ? 64  ILE   B CA   1 
ATOM   3289 C C    . ILE   B 1 84  ? 36.656 -23.587 7.369  1.00 22.50 ? 64  ILE   B C    1 
ATOM   3290 O O    . ILE   B 1 84  ? 35.539 -23.173 7.696  1.00 19.14 ? 64  ILE   B O    1 
ATOM   3291 C CB   . ILE   B 1 84  ? 37.714 -24.146 9.583  1.00 20.92 ? 64  ILE   B CB   1 
ATOM   3292 C CG1  . ILE   B 1 84  ? 38.863 -23.805 10.540 1.00 33.07 ? 64  ILE   B CG1  1 
ATOM   3293 C CG2  . ILE   B 1 84  ? 37.649 -25.638 9.268  1.00 27.68 ? 64  ILE   B CG2  1 
ATOM   3294 C CD1  . ILE   B 1 84  ? 40.052 -24.729 10.472 1.00 46.45 ? 64  ILE   B CD1  1 
ATOM   3295 H H    . ILE   B 1 84  ? 37.252 -21.624 8.980  1.00 23.92 ? 64  ILE   B H    1 
ATOM   3296 H HA   . ILE   B 1 84  ? 38.659 -23.655 7.833  1.00 22.52 ? 64  ILE   B HA   1 
ATOM   3297 H HB   . ILE   B 1 84  ? 36.891 -23.896 10.031 1.00 25.12 ? 64  ILE   B HB   1 
ATOM   3298 H HG12 . ILE   B 1 84  ? 39.178 -22.912 10.333 1.00 39.70 ? 64  ILE   B HG12 1 
ATOM   3299 H HG13 . ILE   B 1 84  ? 38.524 -23.836 11.448 1.00 39.70 ? 64  ILE   B HG13 1 
ATOM   3300 H HG21 . ILE   B 1 84  ? 37.604 -26.135 10.101 1.00 33.23 ? 64  ILE   B HG21 1 
ATOM   3301 H HG22 . ILE   B 1 84  ? 36.857 -25.814 8.736  1.00 33.23 ? 64  ILE   B HG22 1 
ATOM   3302 H HG23 . ILE   B 1 84  ? 38.443 -25.892 8.774  1.00 33.23 ? 64  ILE   B HG23 1 
ATOM   3303 H HD11 . ILE   B 1 84  ? 40.814 -24.294 10.885 1.00 55.75 ? 64  ILE   B HD11 1 
ATOM   3304 H HD12 . ILE   B 1 84  ? 39.842 -25.549 10.946 1.00 55.75 ? 64  ILE   B HD12 1 
ATOM   3305 H HD13 . ILE   B 1 84  ? 40.247 -24.925 9.542  1.00 55.75 ? 64  ILE   B HD13 1 
ATOM   3306 N N    . ARG   B 1 85  ? 36.874 -24.235 6.227  1.00 19.97 ? 65  ARG   B N    1 
ATOM   3307 C CA   . ARG   B 1 85  ? 35.815 -24.417 5.247  1.00 20.38 ? 65  ARG   B CA   1 
ATOM   3308 C C    . ARG   B 1 85  ? 35.406 -25.877 5.200  1.00 21.89 ? 65  ARG   B C    1 
ATOM   3309 O O    . ARG   B 1 85  ? 36.224 -26.753 4.893  1.00 24.56 ? 65  ARG   B O    1 
ATOM   3310 C CB   . ARG   B 1 85  ? 36.236 -23.936 3.863  1.00 23.98 ? 65  ARG   B CB   1 
ATOM   3311 C CG   . ARG   B 1 85  ? 35.119 -24.071 2.841  1.00 33.58 ? 65  ARG   B CG   1 
ATOM   3312 C CD   . ARG   B 1 85  ? 35.475 -23.418 1.522  1.00 47.14 ? 65  ARG   B CD   1 
ATOM   3313 N NE   . ARG   B 1 85  ? 35.724 -21.990 1.671  1.00 49.04 ? 65  ARG   B NE   1 
ATOM   3314 C CZ   . ARG   B 1 85  ? 34.823 -21.045 1.439  1.00 38.22 ? 65  ARG   B CZ   1 
ATOM   3315 N NH1  . ARG   B 1 85  ? 33.597 -21.340 1.035  1.00 45.06 ? 65  ARG   B NH1  1 
ATOM   3316 N NH2  . ARG   B 1 85  ? 35.161 -19.771 1.610  1.00 47.81 ? 65  ARG   B NH2  1 
ATOM   3317 H H    . ARG   B 1 85  ? 37.630 -24.576 6.000  1.00 23.98 ? 65  ARG   B H    1 
ATOM   3318 H HA   . ARG   B 1 85  ? 35.046 -23.896 5.529  1.00 24.46 ? 65  ARG   B HA   1 
ATOM   3319 H HB2  . ARG   B 1 85  ? 36.488 -23.001 3.914  1.00 28.79 ? 65  ARG   B HB2  1 
ATOM   3320 H HB3  . ARG   B 1 85  ? 36.990 -24.466 3.559  1.00 28.79 ? 65  ARG   B HB3  1 
ATOM   3321 H HG2  . ARG   B 1 85  ? 34.949 -25.012 2.677  1.00 40.31 ? 65  ARG   B HG2  1 
ATOM   3322 H HG3  . ARG   B 1 85  ? 34.319 -23.644 3.185  1.00 40.31 ? 65  ARG   B HG3  1 
ATOM   3323 H HD2  . ARG   B 1 85  ? 36.278 -23.830 1.168  1.00 56.58 ? 65  ARG   B HD2  1 
ATOM   3324 H HD3  . ARG   B 1 85  ? 34.740 -23.534 0.900  1.00 56.58 ? 65  ARG   B HD3  1 
ATOM   3325 H HE   . ARG   B 1 85  ? 36.507 -21.744 1.927  1.00 58.86 ? 65  ARG   B HE   1 
ATOM   3326 H HH11 . ARG   B 1 85  ? 33.369 -22.161 0.918  1.00 54.08 ? 65  ARG   B HH11 1 
ATOM   3327 H HH12 . ARG   B 1 85  ? 33.029 -20.711 0.890  1.00 54.08 ? 65  ARG   B HH12 1 
ATOM   3328 H HH21 . ARG   B 1 85  ? 35.956 -19.568 1.869  1.00 57.38 ? 65  ARG   B HH21 1 
ATOM   3329 H HH22 . ARG   B 1 85  ? 34.585 -19.149 1.463  1.00 57.38 ? 65  ARG   B HH22 1 
ATOM   3330 N N    . GLY   B 1 86  ? 34.144 -26.132 5.498  1.00 19.47 ? 66  GLY   B N    1 
ATOM   3331 C CA   . GLY   B 1 86  ? 33.611 -27.481 5.448  1.00 23.84 ? 66  GLY   B CA   1 
ATOM   3332 C C    . GLY   B 1 86  ? 33.175 -27.996 6.801  1.00 22.04 ? 66  GLY   B C    1 
ATOM   3333 O O    . GLY   B 1 86  ? 33.939 -27.946 7.766  1.00 21.39 ? 66  GLY   B O    1 
ATOM   3334 H H    A GLY   B 1 86  ? 33.570 -25.536 5.734  0.56 23.38 ? 66  GLY   B H    1 
ATOM   3335 H H    B GLY   B 1 86  ? 33.570 -25.536 5.734  0.44 23.38 ? 66  GLY   B H    1 
ATOM   3336 H HA2  . GLY   B 1 86  ? 32.844 -27.499 4.856  1.00 28.62 ? 66  GLY   B HA2  1 
ATOM   3337 H HA3  . GLY   B 1 86  ? 34.292 -28.079 5.101  1.00 28.62 ? 66  GLY   B HA3  1 
ATOM   3338 N N    . ARG   B 1 87  ? 31.943 -28.497 6.867  1.00 21.60 ? 67  ARG   B N    1 
ATOM   3339 C CA   . ARG   B 1 87  ? 31.412 -29.058 8.101  1.00 19.31 ? 67  ARG   B CA   1 
ATOM   3340 C C    . ARG   B 1 87  ? 32.356 -30.087 8.708  1.00 20.59 ? 67  ARG   B C    1 
ATOM   3341 O O    . ARG   B 1 87  ? 32.628 -30.065 9.915  1.00 19.94 ? 67  ARG   B O    1 
ATOM   3342 C CB   . ARG   B 1 87  ? 30.044 -29.678 7.825  1.00 22.41 ? 67  ARG   B CB   1 
ATOM   3343 C CG   . ARG   B 1 87  ? 29.354 -30.292 9.016  1.00 21.01 ? 67  ARG   B CG   1 
ATOM   3344 C CD   . ARG   B 1 87  ? 28.100 -30.989 8.536  1.00 27.77 ? 67  ARG   B CD   1 
ATOM   3345 N NE   . ARG   B 1 87  ? 28.480 -32.126 7.705  1.00 45.42 ? 67  ARG   B NE   1 
ATOM   3346 C CZ   . ARG   B 1 87  ? 27.784 -32.588 6.677  1.00 45.92 ? 67  ARG   B CZ   1 
ATOM   3347 N NH1  . ARG   B 1 87  ? 26.627 -32.053 6.332  1.00 28.60 ? 67  ARG   B NH1  1 
ATOM   3348 N NH2  . ARG   B 1 87  ? 28.272 -33.605 5.971  1.00 40.26 ? 67  ARG   B NH2  1 
ATOM   3349 H H    . ARG   B 1 87  ? 31.392 -28.523 6.207  1.00 25.93 ? 67  ARG   B H    1 
ATOM   3350 H HA   . ARG   B 1 87  ? 31.308 -28.344 8.750  1.00 23.19 ? 67  ARG   B HA   1 
ATOM   3351 H HB2  . ARG   B 1 87  ? 29.460 -28.986 7.479  1.00 26.91 ? 67  ARG   B HB2  1 
ATOM   3352 H HB3  . ARG   B 1 87  ? 30.156 -30.379 7.164  1.00 26.91 ? 67  ARG   B HB3  1 
ATOM   3353 H HG2  . ARG   B 1 87  ? 29.937 -30.941 9.440  1.00 25.23 ? 67  ARG   B HG2  1 
ATOM   3354 H HG3  . ARG   B 1 87  ? 29.110 -29.601 9.652  1.00 25.23 ? 67  ARG   B HG3  1 
ATOM   3355 H HD2  . ARG   B 1 87  ? 27.588 -31.310 9.295  1.00 33.34 ? 67  ARG   B HD2  1 
ATOM   3356 H HD3  . ARG   B 1 87  ? 27.562 -30.378 8.008  1.00 33.34 ? 67  ARG   B HD3  1 
ATOM   3357 H HE   . ARG   B 1 87  ? 29.215 -32.529 7.898  1.00 54.52 ? 67  ARG   B HE   1 
ATOM   3358 H HH11 . ARG   B 1 87  ? 26.310 -31.390 6.778  1.00 34.33 ? 67  ARG   B HH11 1 
ATOM   3359 H HH12 . ARG   B 1 87  ? 26.191 -32.368 5.661  1.00 34.33 ? 67  ARG   B HH12 1 
ATOM   3360 H HH21 . ARG   B 1 87  ? 29.028 -33.954 6.185  1.00 48.33 ? 67  ARG   B HH21 1 
ATOM   3361 H HH22 . ARG   B 1 87  ? 27.830 -33.915 5.301  1.00 48.33 ? 67  ARG   B HH22 1 
ATOM   3362 N N    . GLU   B 1 88  ? 32.859 -31.017 7.895  1.00 22.29 ? 68  GLU   B N    1 
ATOM   3363 C CA   . GLU   B 1 88  ? 33.703 -32.053 8.477  1.00 21.93 ? 68  GLU   B CA   1 
ATOM   3364 C C    . GLU   B 1 88  ? 35.047 -31.489 8.924  1.00 20.67 ? 68  GLU   B C    1 
ATOM   3365 O O    . GLU   B 1 88  ? 35.562 -31.895 9.972  1.00 21.30 ? 68  GLU   B O    1 
ATOM   3366 C CB   . GLU   B 1 88  ? 33.852 -33.214 7.492  1.00 31.27 ? 68  GLU   B CB   1 
ATOM   3367 C CG   . GLU   B 1 88  ? 32.511 -33.918 7.189  1.00 40.88 ? 68  GLU   B CG   1 
ATOM   3368 C CD   . GLU   B 1 88  ? 31.720 -34.320 8.438  1.00 56.29 ? 68  GLU   B CD   1 
ATOM   3369 O OE1  . GLU   B 1 88  ? 32.319 -34.874 9.384  1.00 62.74 ? 68  GLU   B OE1  1 
ATOM   3370 O OE2  . GLU   B 1 88  ? 30.489 -34.085 8.471  1.00 46.99 ? 68  GLU   B OE2  1 
ATOM   3371 H H    . GLU   B 1 88  ? 32.733 -31.066 7.046  1.00 26.75 ? 68  GLU   B H    1 
ATOM   3372 H HA   . GLU   B 1 88  ? 33.279 -32.418 9.270  1.00 26.32 ? 68  GLU   B HA   1 
ATOM   3373 H HB2  . GLU   B 1 88  ? 34.208 -32.874 6.656  1.00 37.54 ? 68  GLU   B HB2  1 
ATOM   3374 H HB3  . GLU   B 1 88  ? 34.458 -33.871 7.868  1.00 37.54 ? 68  GLU   B HB3  1 
ATOM   3375 H HG2  . GLU   B 1 88  ? 31.955 -33.317 6.670  1.00 49.06 ? 68  GLU   B HG2  1 
ATOM   3376 H HG3  . GLU   B 1 88  ? 32.691 -34.725 6.683  1.00 49.06 ? 68  GLU   B HG3  1 
ATOM   3377 N N    . LYS   B 1 89  ? 35.599 -30.510 8.201  1.00 20.06 ? 69  LYS   B N    1 
ATOM   3378 C CA   . LYS   B 1 89  ? 36.812 -29.851 8.684  1.00 19.48 ? 69  LYS   B CA   1 
ATOM   3379 C C    . LYS   B 1 89  ? 36.548 -29.053 9.961  1.00 18.26 ? 69  LYS   B C    1 
ATOM   3380 O O    . LYS   B 1 89  ? 37.408 -28.994 10.843 1.00 21.86 ? 69  LYS   B O    1 
ATOM   3381 C CB   . LYS   B 1 89  ? 37.388 -28.942 7.603  1.00 19.74 ? 69  LYS   B CB   1 
ATOM   3382 C CG   . LYS   B 1 89  ? 37.954 -29.693 6.402  1.00 33.60 ? 69  LYS   B CG   1 
ATOM   3383 C CD   . LYS   B 1 89  ? 39.450 -29.441 6.258  1.00 49.01 ? 69  LYS   B CD   1 
ATOM   3384 C CE   . LYS   B 1 89  ? 40.054 -30.237 5.109  1.00 68.39 ? 69  LYS   B CE   1 
ATOM   3385 N NZ   . LYS   B 1 89  ? 39.504 -29.824 3.789  1.00 64.27 ? 69  LYS   B NZ   1 
ATOM   3386 H H    . LYS   B 1 89  ? 35.300 -30.218 7.450  1.00 24.09 ? 69  LYS   B H    1 
ATOM   3387 H HA   . LYS   B 1 89  ? 37.474 -30.531 8.884  1.00 23.38 ? 69  LYS   B HA   1 
ATOM   3388 H HB2  . LYS   B 1 89  ? 36.684 -28.358 7.281  1.00 23.70 ? 69  LYS   B HB2  1 
ATOM   3389 H HB3  . LYS   B 1 89  ? 38.106 -28.416 7.989  1.00 23.70 ? 69  LYS   B HB3  1 
ATOM   3390 H HG2  . LYS   B 1 89  ? 37.814 -30.646 6.520  1.00 40.34 ? 69  LYS   B HG2  1 
ATOM   3391 H HG3  . LYS   B 1 89  ? 37.513 -29.390 5.593  1.00 40.34 ? 69  LYS   B HG3  1 
ATOM   3392 H HD2  . LYS   B 1 89  ? 39.600 -28.498 6.086  1.00 58.83 ? 69  LYS   B HD2  1 
ATOM   3393 H HD3  . LYS   B 1 89  ? 39.899 -29.704 7.077  1.00 58.83 ? 69  LYS   B HD3  1 
ATOM   3394 H HE2  . LYS   B 1 89  ? 41.013 -30.096 5.094  1.00 82.09 ? 69  LYS   B HE2  1 
ATOM   3395 H HE3  . LYS   B 1 89  ? 39.859 -31.178 5.237  1.00 82.09 ? 69  LYS   B HE3  1 
ATOM   3396 H HZ1  . LYS   B 1 89  ? 39.930 -30.252 3.134  1.00 77.13 ? 69  LYS   B HZ1  1 
ATOM   3397 H HZ2  . LYS   B 1 89  ? 38.637 -30.020 3.745  1.00 77.13 ? 69  LYS   B HZ2  1 
ATOM   3398 H HZ3  . LYS   B 1 89  ? 39.608 -28.947 3.676  1.00 77.13 ? 69  LYS   B HZ3  1 
ATOM   3399 N N    . LEU   B 1 90  ? 35.364 -28.446 10.085 1.00 18.48 ? 70  LEU   B N    1 
ATOM   3400 C CA   . LEU   B 1 90  ? 35.009 -27.781 11.331 1.00 17.69 ? 70  LEU   B CA   1 
ATOM   3401 C C    . LEU   B 1 90  ? 34.958 -28.777 12.478 1.00 18.64 ? 70  LEU   B C    1 
ATOM   3402 O O    . LEU   B 1 90  ? 35.389 -28.467 13.596 1.00 19.73 ? 70  LEU   B O    1 
ATOM   3403 C CB   . LEU   B 1 90  ? 33.674 -27.052 11.166 1.00 14.46 ? 70  LEU   B CB   1 
ATOM   3404 C CG   . LEU   B 1 90  ? 33.720 -25.744 10.394 1.00 20.93 ? 70  LEU   B CG   1 
ATOM   3405 C CD1  . LEU   B 1 90  ? 32.333 -25.361 9.930  1.00 20.02 ? 70  LEU   B CD1  1 
ATOM   3406 C CD2  . LEU   B 1 90  ? 34.326 -24.656 11.265 1.00 22.84 ? 70  LEU   B CD2  1 
ATOM   3407 H H    . LEU   B 1 90  ? 34.762 -28.408 9.471  1.00 22.19 ? 70  LEU   B H    1 
ATOM   3408 H HA   . LEU   B 1 90  ? 35.680 -27.115 11.548 1.00 21.24 ? 70  LEU   B HA   1 
ATOM   3409 H HB2  . LEU   B 1 90  ? 33.064 -27.642 10.696 1.00 17.36 ? 70  LEU   B HB2  1 
ATOM   3410 H HB3  . LEU   B 1 90  ? 33.327 -26.852 12.050 1.00 17.36 ? 70  LEU   B HB3  1 
ATOM   3411 H HG   . LEU   B 1 90  ? 34.276 -25.844 9.605  1.00 25.13 ? 70  LEU   B HG   1 
ATOM   3412 H HD11 . LEU   B 1 90  ? 32.376 -24.503 9.481  1.00 24.04 ? 70  LEU   B HD11 1 
ATOM   3413 H HD12 . LEU   B 1 90  ? 32.006 -26.039 9.319  1.00 24.04 ? 70  LEU   B HD12 1 
ATOM   3414 H HD13 . LEU   B 1 90  ? 31.748 -25.302 10.702 1.00 24.04 ? 70  LEU   B HD13 1 
ATOM   3415 H HD21 . LEU   B 1 90  ? 34.458 -23.858 10.729 1.00 27.43 ? 70  LEU   B HD21 1 
ATOM   3416 H HD22 . LEU   B 1 90  ? 33.721 -24.465 11.999 1.00 27.43 ? 70  LEU   B HD22 1 
ATOM   3417 H HD23 . LEU   B 1 90  ? 35.178 -24.966 11.611 1.00 27.43 ? 70  LEU   B HD23 1 
ATOM   3418 N N    . GLY   B 1 91  ? 34.448 -29.984 12.220 1.00 17.68 ? 71  GLY   B N    1 
ATOM   3419 C CA   . GLY   B 1 91  ? 34.437 -30.996 13.258 1.00 17.72 ? 71  GLY   B CA   1 
ATOM   3420 C C    . GLY   B 1 91  ? 35.831 -31.410 13.683 1.00 17.77 ? 71  GLY   B C    1 
ATOM   3421 O O    . GLY   B 1 91  ? 36.099 -31.608 14.873 1.00 20.97 ? 71  GLY   B O    1 
ATOM   3422 H H    . GLY   B 1 91  ? 34.111 -30.230 11.468 1.00 21.23 ? 71  GLY   B H    1 
ATOM   3423 H HA2  . GLY   B 1 91  ? 33.971 -30.652 14.036 1.00 21.28 ? 71  GLY   B HA2  1 
ATOM   3424 H HA3  . GLY   B 1 91  ? 33.972 -31.783 12.933 1.00 21.28 ? 71  GLY   B HA3  1 
ATOM   3425 N N    . GLU   B 1 92  ? 36.737 -31.551 12.718 1.00 22.43 ? 72  GLU   B N    1 
ATOM   3426 C CA   . GLU   B 1 92  ? 38.115 -31.887 13.052 1.00 24.06 ? 72  GLU   B CA   1 
ATOM   3427 C C    . GLU   B 1 92  ? 38.763 -30.778 13.865 1.00 22.58 ? 72  GLU   B C    1 
ATOM   3428 O O    . GLU   B 1 92  ? 39.486 -31.045 14.831 1.00 28.24 ? 72  GLU   B O    1 
ATOM   3429 C CB   . GLU   B 1 92  ? 38.894 -32.164 11.771 1.00 24.74 ? 72  GLU   B CB   1 
ATOM   3430 C CG   . GLU   B 1 92  ? 38.448 -33.469 11.147 1.00 36.44 ? 72  GLU   B CG   1 
ATOM   3431 C CD   . GLU   B 1 92  ? 38.852 -33.607 9.703  1.00 48.99 ? 72  GLU   B CD   1 
ATOM   3432 O OE1  . GLU   B 1 92  ? 39.754 -32.867 9.266  1.00 39.66 ? 72  GLU   B OE1  1 
ATOM   3433 O OE2  . GLU   B 1 92  ? 38.261 -34.456 9.004  1.00 48.42 ? 72  GLU   B OE2  1 
ATOM   3434 H H    . GLU   B 1 92  ? 36.582 -31.459 11.877 1.00 26.93 ? 72  GLU   B H    1 
ATOM   3435 H HA   . GLU   B 1 92  ? 38.134 -32.692 13.591 1.00 28.89 ? 72  GLU   B HA   1 
ATOM   3436 H HB2  . GLU   B 1 92  ? 38.738 -31.448 11.136 1.00 29.70 ? 72  GLU   B HB2  1 
ATOM   3437 H HB3  . GLU   B 1 92  ? 39.841 -32.227 11.975 1.00 29.70 ? 72  GLU   B HB3  1 
ATOM   3438 H HG2  . GLU   B 1 92  ? 38.846 -34.204 11.639 1.00 43.74 ? 72  GLU   B HG2  1 
ATOM   3439 H HG3  . GLU   B 1 92  ? 37.481 -33.524 11.193 1.00 43.74 ? 72  GLU   B HG3  1 
ATOM   3440 N N    . HIS   B 1 93  ? 38.483 -29.528 13.520 1.00 23.58 ? 73  HIS   B N    1 
ATOM   3441 C CA   . HIS   B 1 93  ? 39.059 -28.419 14.264 1.00 21.37 ? 73  HIS   B CA   1 
ATOM   3442 C C    . HIS   B 1 93  ? 38.562 -28.389 15.702 1.00 23.74 ? 73  HIS   B C    1 
ATOM   3443 O O    . HIS   B 1 93  ? 39.293 -27.948 16.596 1.00 22.25 ? 73  HIS   B O    1 
ATOM   3444 C CB   . HIS   B 1 93  ? 38.722 -27.119 13.542 1.00 24.64 ? 73  HIS   B CB   1 
ATOM   3445 C CG   . HIS   B 1 93  ? 38.519 -25.951 14.450 1.00 35.05 ? 73  HIS   B CG   1 
ATOM   3446 N ND1  . HIS   B 1 93  ? 39.561 -25.163 14.887 1.00 33.82 ? 73  HIS   B ND1  1 
ATOM   3447 C CD2  . HIS   B 1 93  ? 37.392 -25.426 14.988 1.00 50.90 ? 73  HIS   B CD2  1 
ATOM   3448 C CE1  . HIS   B 1 93  ? 39.083 -24.205 15.662 1.00 34.85 ? 73  HIS   B CE1  1 
ATOM   3449 N NE2  . HIS   B 1 93  ? 37.770 -24.344 15.741 1.00 40.00 ? 73  HIS   B NE2  1 
ATOM   3450 H H    . HIS   B 1 93  ? 37.970 -29.298 12.869 1.00 28.30 ? 73  HIS   B H    1 
ATOM   3451 H HA   . HIS   B 1 93  ? 40.024 -28.510 14.300 1.00 25.65 ? 73  HIS   B HA   1 
ATOM   3452 H HB2  . HIS   B 1 93  ? 39.451 -26.901 12.940 1.00 29.58 ? 73  HIS   B HB2  1 
ATOM   3453 H HB3  . HIS   B 1 93  ? 37.903 -27.247 13.039 1.00 29.58 ? 73  HIS   B HB3  1 
ATOM   3454 H HD1  . HIS   B 1 93  ? 40.390 -25.276 14.688 1.00 40.59 ? 73  HIS   B HD1  1 
ATOM   3455 H HD2  . HIS   B 1 93  ? 36.524 -25.740 14.870 1.00 61.09 ? 73  HIS   B HD2  1 
ATOM   3456 H HE1  . HIS   B 1 93  ? 39.585 -23.544 16.082 1.00 41.84 ? 73  HIS   B HE1  1 
ATOM   3457 N N    . ALA   B 1 94  ? 37.339 -28.875 15.957 1.00 20.36 ? 74  ALA   B N    1 
ATOM   3458 C CA   . ALA   B 1 94  ? 36.813 -28.829 17.316 1.00 21.85 ? 74  ALA   B CA   1 
ATOM   3459 C C    . ALA   B 1 94  ? 37.716 -29.591 18.271 1.00 19.90 ? 74  ALA   B C    1 
ATOM   3460 O O    . ALA   B 1 94  ? 37.795 -29.260 19.458 1.00 19.79 ? 74  ALA   B O    1 
ATOM   3461 C CB   . ALA   B 1 94  ? 35.399 -29.398 17.363 1.00 20.51 ? 74  ALA   B CB   1 
ATOM   3462 H H    . ALA   B 1 94  ? 36.813 -29.225 15.374 1.00 24.44 ? 74  ALA   B H    1 
ATOM   3463 H HA   . ALA   B 1 94  ? 36.765 -27.903 17.603 1.00 26.23 ? 74  ALA   B HA   1 
ATOM   3464 H HB1  . ALA   B 1 94  ? 34.902 -28.953 18.068 1.00 24.62 ? 74  ALA   B HB1  1 
ATOM   3465 H HB2  . ALA   B 1 94  ? 34.968 -29.246 16.508 1.00 24.62 ? 74  ALA   B HB2  1 
ATOM   3466 H HB3  . ALA   B 1 94  ? 35.448 -30.350 17.544 1.00 24.62 ? 74  ALA   B HB3  1 
ATOM   3467 N N    . VAL   B 1 95  ? 38.409 -30.621 17.773 1.00 22.90 ? 75  VAL   B N    1 
ATOM   3468 C CA   . VAL   B 1 95  ? 39.341 -31.355 18.623 1.00 17.67 ? 75  VAL   B CA   1 
ATOM   3469 C C    . VAL   B 1 95  ? 40.441 -30.430 19.118 1.00 17.56 ? 75  VAL   B C    1 
ATOM   3470 O O    . VAL   B 1 95  ? 40.785 -30.419 20.309 1.00 23.27 ? 75  VAL   B O    1 
ATOM   3471 C CB   . VAL   B 1 95  ? 39.933 -32.557 17.867 1.00 27.28 ? 75  VAL   B CB   1 
ATOM   3472 C CG1  . VAL   B 1 95  ? 41.032 -33.196 18.700 1.00 35.21 ? 75  VAL   B CG1  1 
ATOM   3473 C CG2  . VAL   B 1 95  ? 38.846 -33.559 17.536 1.00 32.90 ? 75  VAL   B CG2  1 
ATOM   3474 H H    . VAL   B 1 95  ? 38.356 -30.907 16.964 1.00 27.50 ? 75  VAL   B H    1 
ATOM   3475 H HA   . VAL   B 1 95  ? 38.852 -31.691 19.390 1.00 21.22 ? 75  VAL   B HA   1 
ATOM   3476 H HB   . VAL   B 1 95  ? 40.320 -32.257 17.029 1.00 32.75 ? 75  VAL   B HB   1 
ATOM   3477 H HG11 . VAL   B 1 95  ? 41.203 -34.091 18.366 1.00 42.26 ? 75  VAL   B HG11 1 
ATOM   3478 H HG12 . VAL   B 1 95  ? 41.836 -32.658 18.629 1.00 42.26 ? 75  VAL   B HG12 1 
ATOM   3479 H HG13 . VAL   B 1 95  ? 40.744 -33.238 19.625 1.00 42.26 ? 75  VAL   B HG13 1 
ATOM   3480 H HG21 . VAL   B 1 95  ? 39.257 -34.369 17.193 1.00 39.49 ? 75  VAL   B HG21 1 
ATOM   3481 H HG22 . VAL   B 1 95  ? 38.345 -33.759 18.342 1.00 39.49 ? 75  VAL   B HG22 1 
ATOM   3482 H HG23 . VAL   B 1 95  ? 38.258 -33.178 16.866 1.00 39.49 ? 75  VAL   B HG23 1 
ATOM   3483 N N    . TRP   B 1 96  ? 41.022 -29.655 18.209 1.00 21.16 ? 76  TRP   B N    1 
ATOM   3484 C CA   . TRP   B 1 96  ? 42.062 -28.719 18.608 1.00 20.71 ? 76  TRP   B CA   1 
ATOM   3485 C C    . TRP   B 1 96  ? 41.503 -27.644 19.534 1.00 22.61 ? 76  TRP   B C    1 
ATOM   3486 O O    . TRP   B 1 96  ? 42.156 -27.248 20.508 1.00 22.73 ? 76  TRP   B O    1 
ATOM   3487 C CB   . TRP   B 1 96  ? 42.699 -28.090 17.370 1.00 21.01 ? 76  TRP   B CB   1 
ATOM   3488 C CG   . TRP   B 1 96  ? 43.665 -27.036 17.735 1.00 21.85 ? 76  TRP   B CG   1 
ATOM   3489 C CD1  . TRP   B 1 96  ? 45.012 -27.174 17.901 1.00 30.22 ? 76  TRP   B CD1  1 
ATOM   3490 C CD2  . TRP   B 1 96  ? 43.363 -25.669 18.029 1.00 29.33 ? 76  TRP   B CD2  1 
ATOM   3491 N NE1  . TRP   B 1 96  ? 45.568 -25.974 18.266 1.00 34.56 ? 76  TRP   B NE1  1 
ATOM   3492 C CE2  . TRP   B 1 96  ? 44.576 -25.033 18.351 1.00 30.13 ? 76  TRP   B CE2  1 
ATOM   3493 C CE3  . TRP   B 1 96  ? 42.183 -24.920 18.043 1.00 29.68 ? 76  TRP   B CE3  1 
ATOM   3494 C CZ2  . TRP   B 1 96  ? 44.642 -23.686 18.687 1.00 23.05 ? 76  TRP   B CZ2  1 
ATOM   3495 C CZ3  . TRP   B 1 96  ? 42.252 -23.585 18.375 1.00 33.50 ? 76  TRP   B CZ3  1 
ATOM   3496 C CH2  . TRP   B 1 96  ? 43.471 -22.981 18.692 1.00 28.14 ? 76  TRP   B CH2  1 
ATOM   3497 H H    . TRP   B 1 96  ? 40.836 -29.652 17.369 1.00 25.40 ? 76  TRP   B H    1 
ATOM   3498 H HA   . TRP   B 1 96  ? 42.754 -29.199 19.088 1.00 24.86 ? 76  TRP   B HA   1 
ATOM   3499 H HB2  . TRP   B 1 96  ? 43.169 -28.774 16.868 1.00 25.22 ? 76  TRP   B HB2  1 
ATOM   3500 H HB3  . TRP   B 1 96  ? 42.006 -27.692 16.820 1.00 25.22 ? 76  TRP   B HB3  1 
ATOM   3501 H HD1  . TRP   B 1 96  ? 45.484 -27.967 17.783 1.00 36.28 ? 76  TRP   B HD1  1 
ATOM   3502 H HE1  . TRP   B 1 96  ? 46.403 -25.835 18.418 1.00 41.48 ? 76  TRP   B HE1  1 
ATOM   3503 H HE3  . TRP   B 1 96  ? 41.368 -25.315 17.832 1.00 35.63 ? 76  TRP   B HE3  1 
ATOM   3504 H HZ2  . TRP   B 1 96  ? 45.452 -23.280 18.901 1.00 27.67 ? 76  TRP   B HZ2  1 
ATOM   3505 H HZ3  . TRP   B 1 96  ? 41.473 -23.077 18.389 1.00 40.21 ? 76  TRP   B HZ3  1 
ATOM   3506 H HH2  . TRP   B 1 96  ? 43.487 -22.078 18.911 1.00 33.79 ? 76  TRP   B HH2  1 
ATOM   3507 N N    . SER   B 1 97  ? 40.292 -27.176 19.240 1.00 19.28 ? 77  SER   B N    1 
ATOM   3508 C CA   . SER   B 1 97  ? 39.665 -26.122 20.033 1.00 19.04 ? 77  SER   B CA   1 
ATOM   3509 C C    . SER   B 1 97  ? 39.492 -26.552 21.480 1.00 18.49 ? 77  SER   B C    1 
ATOM   3510 O O    . SER   B 1 97  ? 39.757 -25.773 22.409 1.00 20.88 ? 77  SER   B O    1 
ATOM   3511 C CB   . SER   B 1 97  ? 38.314 -25.772 19.404 1.00 20.86 ? 77  SER   B CB   1 
ATOM   3512 O OG   . SER   B 1 97  ? 37.601 -24.820 20.177 1.00 22.62 ? 77  SER   B OG   1 
ATOM   3513 H H    . SER   B 1 97  ? 39.809 -27.451 18.584 1.00 23.15 ? 77  SER   B H    1 
ATOM   3514 H HA   . SER   B 1 97  ? 40.226 -25.331 20.031 1.00 22.86 ? 77  SER   B HA   1 
ATOM   3515 H HB2  . SER   B 1 97  ? 38.469 -25.402 18.520 1.00 25.05 ? 77  SER   B HB2  1 
ATOM   3516 H HB3  . SER   B 1 97  ? 37.783 -26.580 19.337 1.00 25.05 ? 77  SER   B HB3  1 
ATOM   3517 H HG   . SER   B 1 97  ? 38.127 -24.235 20.469 1.00 27.16 ? 77  SER   B HG   1 
ATOM   3518 N N    . LEU   B 1 98  ? 39.058 -27.792 21.694 1.00 17.58 ? 78  LEU   B N    1 
ATOM   3519 C CA   . LEU   B 1 98  ? 38.855 -28.299 23.044 1.00 22.22 ? 78  LEU   B CA   1 
ATOM   3520 C C    . LEU   B 1 98  ? 40.176 -28.507 23.766 1.00 24.31 ? 78  LEU   B C    1 
ATOM   3521 O O    . LEU   B 1 98  ? 40.236 -28.401 24.996 1.00 24.11 ? 78  LEU   B O    1 
ATOM   3522 C CB   . LEU   B 1 98  ? 38.054 -29.591 22.961 1.00 25.05 ? 78  LEU   B CB   1 
ATOM   3523 C CG   . LEU   B 1 98  ? 37.189 -30.057 24.125 1.00 42.00 ? 78  LEU   B CG   1 
ATOM   3524 C CD1  . LEU   B 1 98  ? 36.241 -29.024 24.645 1.00 23.85 ? 78  LEU   B CD1  1 
ATOM   3525 C CD2  . LEU   B 1 98  ? 36.414 -31.291 23.609 1.00 37.43 ? 78  LEU   B CD2  1 
ATOM   3526 H H    . LEU   B 1 98  ? 38.874 -28.359 21.075 1.00 21.11 ? 78  LEU   B H    1 
ATOM   3527 H HA   . LEU   B 1 98  ? 38.347 -27.661 23.570 1.00 26.67 ? 78  LEU   B HA   1 
ATOM   3528 H HB2  . LEU   B 1 98  ? 37.455 -29.504 22.203 1.00 30.08 ? 78  LEU   B HB2  1 
ATOM   3529 H HB3  . LEU   B 1 98  ? 38.690 -30.307 22.800 1.00 30.08 ? 78  LEU   B HB3  1 
ATOM   3530 H HG   . LEU   B 1 98  ? 37.754 -30.258 24.887 1.00 50.42 ? 78  LEU   B HG   1 
ATOM   3531 H HD11 . LEU   B 1 98  ? 35.845 -29.347 25.470 1.00 28.63 ? 78  LEU   B HD11 1 
ATOM   3532 H HD12 . LEU   B 1 98  ? 36.729 -28.203 24.812 1.00 28.63 ? 78  LEU   B HD12 1 
ATOM   3533 H HD13 . LEU   B 1 98  ? 35.549 -28.869 23.983 1.00 28.63 ? 78  LEU   B HD13 1 
ATOM   3534 H HD21 . LEU   B 1 98  ? 35.843 -31.624 24.319 1.00 44.93 ? 78  LEU   B HD21 1 
ATOM   3535 H HD22 . LEU   B 1 98  ? 35.875 -31.029 22.846 1.00 44.93 ? 78  LEU   B HD22 1 
ATOM   3536 H HD23 . LEU   B 1 98  ? 37.049 -31.975 23.347 1.00 44.93 ? 78  LEU   B HD23 1 
ATOM   3537 N N    . GLN   B 1 99  ? 41.242 -28.801 23.022 1.00 19.99 ? 79  GLN   B N    1 
ATOM   3538 C CA   . GLN   B 1 99  ? 42.557 -28.919 23.641 1.00 23.57 ? 79  GLN   B CA   1 
ATOM   3539 C C    . GLN   B 1 99  ? 43.101 -27.553 24.045 1.00 24.57 ? 79  GLN   B C    1 
ATOM   3540 O O    . GLN   B 1 99  ? 43.618 -27.390 25.156 1.00 26.81 ? 79  GLN   B O    1 
ATOM   3541 C CB   . GLN   B 1 99  ? 43.527 -29.630 22.690 1.00 30.36 ? 79  GLN   B CB   1 
ATOM   3542 C CG   . GLN   B 1 99  ? 44.947 -29.774 23.233 1.00 50.37 ? 79  GLN   B CG   1 
ATOM   3543 C CD   . GLN   B 1 99  ? 45.773 -30.833 22.512 1.00 68.41 ? 79  GLN   B CD   1 
ATOM   3544 O OE1  . GLN   B 1 99  ? 45.350 -31.405 21.506 1.00 52.32 ? 79  GLN   B OE1  1 
ATOM   3545 N NE2  . GLN   B 1 99  ? 46.962 -31.099 23.036 1.00 58.26 ? 79  GLN   B NE2  1 
ATOM   3546 H H    . GLN   B 1 99  ? 41.230 -28.933 22.173 1.00 24.00 ? 79  GLN   B H    1 
ATOM   3547 H HA   . GLN   B 1 99  ? 42.478 -29.460 24.442 1.00 28.29 ? 79  GLN   B HA   1 
ATOM   3548 H HB2  . GLN   B 1 99  ? 43.188 -30.522 22.511 1.00 36.45 ? 79  GLN   B HB2  1 
ATOM   3549 H HB3  . GLN   B 1 99  ? 43.578 -29.124 21.864 1.00 36.45 ? 79  GLN   B HB3  1 
ATOM   3550 H HG2  . GLN   B 1 99  ? 45.406 -28.925 23.137 1.00 60.46 ? 79  GLN   B HG2  1 
ATOM   3551 H HG3  . GLN   B 1 99  ? 44.900 -30.022 24.169 1.00 60.46 ? 79  GLN   B HG3  1 
ATOM   3552 H HE21 . GLN   B 1 99  ? 47.224 -30.682 23.741 1.00 69.92 ? 79  GLN   B HE21 1 
ATOM   3553 H HE22 . GLN   B 1 99  ? 47.471 -31.688 22.670 1.00 69.92 ? 79  GLN   B HE22 1 
ATOM   3554 N N    . CYS   B 1 100 ? 42.957 -26.552 23.189 1.00 20.57 ? 80  CYS   B N    1 
ATOM   3555 C CA   A CYS   B 1 100 ? 43.596 -25.251 23.367 0.38 20.30 ? 80  CYS   B CA   1 
ATOM   3556 C CA   B CYS   B 1 100 ? 43.638 -25.293 23.448 0.62 20.48 ? 80  CYS   B CA   1 
ATOM   3557 C C    . CYS   B 1 100 ? 42.777 -24.288 24.206 1.00 16.48 ? 80  CYS   B C    1 
ATOM   3558 O O    . CYS   B 1 100 ? 43.337 -23.384 24.838 1.00 19.20 ? 80  CYS   B O    1 
ATOM   3559 C CB   A CYS   B 1 100 ? 43.845 -24.589 22.013 0.38 21.27 ? 80  CYS   B CB   1 
ATOM   3560 C CB   B CYS   B 1 100 ? 44.155 -24.719 22.128 0.62 26.66 ? 80  CYS   B CB   1 
ATOM   3561 S SG   A CYS   B 1 100 ? 44.395 -22.873 22.170 0.38 22.56 ? 80  CYS   B SG   1 
ATOM   3562 S SG   B CYS   B 1 100 ? 45.418 -25.829 21.406 0.62 26.07 ? 80  CYS   B SG   1 
ATOM   3563 H H    A CYS   B 1 100 ? 42.481 -26.599 22.474 0.38 24.70 ? 80  CYS   B H    1 
ATOM   3564 H H    B CYS   B 1 100 ? 42.484 -26.576 22.471 0.62 24.70 ? 80  CYS   B H    1 
ATOM   3565 H HA   A CYS   B 1 100 ? 44.446 -25.404 23.809 0.38 24.37 ? 80  CYS   B HA   1 
ATOM   3566 H HA   B CYS   B 1 100 ? 44.415 -25.442 24.009 0.62 24.59 ? 80  CYS   B HA   1 
ATOM   3567 H HB2  A CYS   B 1 100 ? 44.532 -25.083 21.540 0.38 25.54 ? 80  CYS   B HB2  1 
ATOM   3568 H HB2  B CYS   B 1 100 ? 43.420 -24.634 21.501 0.62 32.01 ? 80  CYS   B HB2  1 
ATOM   3569 H HB3  A CYS   B 1 100 ? 43.021 -24.595 21.501 0.38 25.54 ? 80  CYS   B HB3  1 
ATOM   3570 H HB3  B CYS   B 1 100 ? 44.558 -23.851 22.287 0.62 32.01 ? 80  CYS   B HB3  1 
ATOM   3571 H HG   A CYS   B 1 100 ? 44.659 -22.446 21.080 0.38 27.09 ? 80  CYS   B HG   1 
ATOM   3572 H HG   B CYS   B 1 100 ? 46.062 -25.215 20.600 0.62 31.30 ? 80  CYS   B HG   1 
ATOM   3573 N N    . PHE   B 1 101 ? 41.461 -24.457 24.213 1.00 18.22 ? 81  PHE   B N    1 
ATOM   3574 C CA   . PHE   B 1 101 ? 40.549 -23.633 25.007 1.00 17.29 ? 81  PHE   B CA   1 
ATOM   3575 C C    . PHE   B 1 101 ? 39.677 -24.601 25.798 1.00 16.15 ? 81  PHE   B C    1 
ATOM   3576 O O    . PHE   B 1 101 ? 38.494 -24.773 25.502 1.00 15.90 ? 81  PHE   B O    1 
ATOM   3577 C CB   . PHE   B 1 101 ? 39.704 -22.722 24.115 1.00 15.93 ? 81  PHE   B CB   1 
ATOM   3578 C CG   . PHE   B 1 101 ? 40.493 -21.761 23.254 1.00 14.35 ? 81  PHE   B CG   1 
ATOM   3579 C CD1  . PHE   B 1 101 ? 41.074 -20.627 23.788 1.00 13.96 ? 81  PHE   B CD1  1 
ATOM   3580 C CD2  . PHE   B 1 101 ? 40.586 -21.967 21.877 1.00 18.18 ? 81  PHE   B CD2  1 
ATOM   3581 C CE1  . PHE   B 1 101 ? 41.759 -19.726 22.987 1.00 17.25 ? 81  PHE   B CE1  1 
ATOM   3582 C CE2  . PHE   B 1 101 ? 41.275 -21.072 21.073 1.00 20.44 ? 81  PHE   B CE2  1 
ATOM   3583 C CZ   . PHE   B 1 101 ? 41.858 -19.950 21.620 1.00 21.40 ? 81  PHE   B CZ   1 
ATOM   3584 H H    . PHE   B 1 101 ? 41.057 -25.060 23.752 1.00 21.88 ? 81  PHE   B H    1 
ATOM   3585 H HA   . PHE   B 1 101 ? 41.043 -23.059 25.614 1.00 20.76 ? 81  PHE   B HA   1 
ATOM   3586 H HB2  . PHE   B 1 101 ? 39.175 -23.278 23.521 1.00 19.13 ? 81  PHE   B HB2  1 
ATOM   3587 H HB3  . PHE   B 1 101 ? 39.120 -22.193 24.681 1.00 19.13 ? 81  PHE   B HB3  1 
ATOM   3588 H HD1  . PHE   B 1 101 ? 41.004 -20.464 24.701 1.00 16.76 ? 81  PHE   B HD1  1 
ATOM   3589 H HD2  . PHE   B 1 101 ? 40.182 -22.713 21.495 1.00 21.83 ? 81  PHE   B HD2  1 
ATOM   3590 H HE1  . PHE   B 1 101 ? 42.153 -18.973 23.364 1.00 20.72 ? 81  PHE   B HE1  1 
ATOM   3591 H HE2  . PHE   B 1 101 ? 41.345 -21.230 20.159 1.00 24.54 ? 81  PHE   B HE2  1 
ATOM   3592 H HZ   . PHE   B 1 101 ? 42.313 -19.347 21.078 1.00 25.69 ? 81  PHE   B HZ   1 
ATOM   3593 N N    . PRO   B 1 102 ? 40.245 -25.291 26.791 1.00 17.35 ? 82  PRO   B N    1 
ATOM   3594 C CA   . PRO   B 1 102 ? 39.540 -26.456 27.356 1.00 18.48 ? 82  PRO   B CA   1 
ATOM   3595 C C    . PRO   B 1 102 ? 38.249 -26.135 28.090 1.00 17.04 ? 82  PRO   B C    1 
ATOM   3596 O O    . PRO   B 1 102 ? 37.332 -26.971 28.082 1.00 21.87 ? 82  PRO   B O    1 
ATOM   3597 C CB   . PRO   B 1 102 ? 40.581 -27.073 28.309 1.00 19.10 ? 82  PRO   B CB   1 
ATOM   3598 C CG   . PRO   B 1 102 ? 41.574 -25.948 28.579 1.00 19.45 ? 82  PRO   B CG   1 
ATOM   3599 C CD   . PRO   B 1 102 ? 41.624 -25.178 27.290 1.00 19.30 ? 82  PRO   B CD   1 
ATOM   3600 H HA   . PRO   B 1 102 ? 39.337 -27.073 26.636 1.00 22.19 ? 82  PRO   B HA   1 
ATOM   3601 H HB2  . PRO   B 1 102 ? 40.150 -27.361 29.129 1.00 22.93 ? 82  PRO   B HB2  1 
ATOM   3602 H HB3  . PRO   B 1 102 ? 41.017 -27.826 27.880 1.00 22.93 ? 82  PRO   B HB3  1 
ATOM   3603 H HG2  . PRO   B 1 102 ? 41.256 -25.390 29.306 1.00 23.35 ? 82  PRO   B HG2  1 
ATOM   3604 H HG3  . PRO   B 1 102 ? 42.444 -26.316 28.800 1.00 23.35 ? 82  PRO   B HG3  1 
ATOM   3605 H HD2  . PRO   B 1 102 ? 41.862 -24.251 27.448 1.00 23.17 ? 82  PRO   B HD2  1 
ATOM   3606 H HD3  . PRO   B 1 102 ? 42.251 -25.581 26.669 1.00 23.17 ? 82  PRO   B HD3  1 
ATOM   3607 N N    . ASP   B 1 103 ? 38.138 -24.969 28.728 1.00 15.74 ? 83  ASP   B N    1 
ATOM   3608 C CA   . ASP   B 1 103 ? 36.978 -24.651 29.554 1.00 17.57 ? 83  ASP   B CA   1 
ATOM   3609 C C    . ASP   B 1 103 ? 36.204 -23.463 28.999 1.00 16.16 ? 83  ASP   B C    1 
ATOM   3610 O O    . ASP   B 1 103 ? 35.453 -22.808 29.731 1.00 16.81 ? 83  ASP   B O    1 
ATOM   3611 C CB   . ASP   B 1 103 ? 37.405 -24.384 30.998 1.00 16.03 ? 83  ASP   B CB   1 
ATOM   3612 C CG   . ASP   B 1 103 ? 38.298 -23.161 31.137 1.00 22.44 ? 83  ASP   B CG   1 
ATOM   3613 O OD1  . ASP   B 1 103 ? 38.886 -22.722 30.134 1.00 17.70 ? 83  ASP   B OD1  1 
ATOM   3614 O OD2  . ASP   B 1 103 ? 38.415 -22.642 32.272 1.00 34.38 ? 83  ASP   B OD2  1 
ATOM   3615 H H    . ASP   B 1 103 ? 38.728 -24.344 28.696 1.00 18.90 ? 83  ASP   B H    1 
ATOM   3616 H HA   . ASP   B 1 103 ? 36.381 -25.415 29.560 1.00 21.10 ? 83  ASP   B HA   1 
ATOM   3617 H HB2  . ASP   B 1 103 ? 36.613 -24.239 31.539 1.00 19.25 ? 83  ASP   B HB2  1 
ATOM   3618 H HB3  . ASP   B 1 103 ? 37.896 -25.153 31.329 1.00 19.25 ? 83  ASP   B HB3  1 
ATOM   3619 N N    . TRP   B 1 104 ? 36.348 -23.196 27.708 1.00 13.98 ? 84  TRP   B N    1 
ATOM   3620 C CA   . TRP   B 1 104 ? 35.842 -21.958 27.135 1.00 12.31 ? 84  TRP   B CA   1 
ATOM   3621 C C    . TRP   B 1 104 ? 34.346 -21.808 27.324 1.00 12.83 ? 84  TRP   B C    1 
ATOM   3622 O O    . TRP   B 1 104 ? 33.574 -22.733 27.064 1.00 14.38 ? 84  TRP   B O    1 
ATOM   3623 C CB   . TRP   B 1 104 ? 36.152 -21.927 25.649 1.00 13.62 ? 84  TRP   B CB   1 
ATOM   3624 C CG   . TRP   B 1 104 ? 35.863 -20.610 25.043 1.00 12.08 ? 84  TRP   B CG   1 
ATOM   3625 C CD1  . TRP   B 1 104 ? 34.783 -20.263 24.310 1.00 14.13 ? 84  TRP   B CD1  1 
ATOM   3626 C CD2  . TRP   B 1 104 ? 36.687 -19.461 25.140 1.00 12.80 ? 84  TRP   B CD2  1 
ATOM   3627 N NE1  . TRP   B 1 104 ? 34.878 -18.955 23.926 1.00 14.01 ? 84  TRP   B NE1  1 
ATOM   3628 C CE2  . TRP   B 1 104 ? 36.044 -18.431 24.423 1.00 12.62 ? 84  TRP   B CE2  1 
ATOM   3629 C CE3  . TRP   B 1 104 ? 37.917 -19.195 25.759 1.00 13.08 ? 84  TRP   B CE3  1 
ATOM   3630 C CZ2  . TRP   B 1 104 ? 36.594 -17.159 24.299 1.00 14.67 ? 84  TRP   B CZ2  1 
ATOM   3631 C CZ3  . TRP   B 1 104 ? 38.448 -17.927 25.637 1.00 14.56 ? 84  TRP   B CZ3  1 
ATOM   3632 C CH2  . TRP   B 1 104 ? 37.785 -16.934 24.913 1.00 14.63 ? 84  TRP   B CH2  1 
ATOM   3633 H H    . TRP   B 1 104 ? 36.734 -23.716 27.142 1.00 16.79 ? 84  TRP   B H    1 
ATOM   3634 H HA   . TRP   B 1 104 ? 36.274 -21.216 27.586 1.00 14.79 ? 84  TRP   B HA   1 
ATOM   3635 H HB2  . TRP   B 1 104 ? 37.094 -22.119 25.518 1.00 16.36 ? 84  TRP   B HB2  1 
ATOM   3636 H HB3  . TRP   B 1 104 ? 35.611 -22.593 25.198 1.00 16.36 ? 84  TRP   B HB3  1 
ATOM   3637 H HD1  . TRP   B 1 104 ? 34.078 -20.831 24.098 1.00 16.97 ? 84  TRP   B HD1  1 
ATOM   3638 H HE1  . TRP   B 1 104 ? 34.301 -18.530 23.451 1.00 16.83 ? 84  TRP   B HE1  1 
ATOM   3639 H HE3  . TRP   B 1 104 ? 38.363 -19.855 26.239 1.00 15.71 ? 84  TRP   B HE3  1 
ATOM   3640 H HZ2  . TRP   B 1 104 ? 36.164 -16.491 23.815 1.00 17.62 ? 84  TRP   B HZ2  1 
ATOM   3641 H HZ3  . TRP   B 1 104 ? 39.261 -17.731 26.043 1.00 17.48 ? 84  TRP   B HZ3  1 
ATOM   3642 H HH2  . TRP   B 1 104 ? 38.171 -16.091 24.850 1.00 17.56 ? 84  TRP   B HH2  1 
ATOM   3643 N N    . VAL   B 1 105 ? 33.923 -20.610 27.719 1.00 14.16 ? 85  VAL   B N    1 
ATOM   3644 C CA   . VAL   B 1 105 ? 32.504 -20.300 27.780 1.00 12.57 ? 85  VAL   B CA   1 
ATOM   3645 C C    . VAL   B 1 105 ? 32.257 -18.925 27.182 1.00 12.25 ? 85  VAL   B C    1 
ATOM   3646 O O    . VAL   B 1 105 ? 33.058 -18.001 27.350 1.00 13.29 ? 85  VAL   B O    1 
ATOM   3647 C CB   . VAL   B 1 105 ? 31.928 -20.372 29.214 1.00 12.93 ? 85  VAL   B CB   1 
ATOM   3648 C CG1  . VAL   B 1 105 ? 31.967 -21.802 29.717 1.00 14.19 ? 85  VAL   B CG1  1 
ATOM   3649 C CG2  . VAL   B 1 105 ? 32.654 -19.417 30.158 1.00 14.53 ? 85  VAL   B CG2  1 
ATOM   3650 H H    . VAL   B 1 105 ? 34.440 -19.964 27.955 1.00 17.01 ? 85  VAL   B H    1 
ATOM   3651 H HA   . VAL   B 1 105 ? 32.041 -20.959 27.239 1.00 15.10 ? 85  VAL   B HA   1 
ATOM   3652 H HB   . VAL   B 1 105 ? 31.001 -20.086 29.197 1.00 15.52 ? 85  VAL   B HB   1 
ATOM   3653 H HG11 . VAL   B 1 105 ? 31.584 -21.834 30.608 1.00 17.04 ? 85  VAL   B HG11 1 
ATOM   3654 H HG12 . VAL   B 1 105 ? 31.452 -22.363 29.116 1.00 17.04 ? 85  VAL   B HG12 1 
ATOM   3655 H HG13 . VAL   B 1 105 ? 32.888 -22.104 29.742 1.00 17.04 ? 85  VAL   B HG13 1 
ATOM   3656 H HG21 . VAL   B 1 105 ? 32.351 -19.579 31.065 1.00 17.45 ? 85  VAL   B HG21 1 
ATOM   3657 H HG22 . VAL   B 1 105 ? 33.609 -19.576 30.094 1.00 17.45 ? 85  VAL   B HG22 1 
ATOM   3658 H HG23 . VAL   B 1 105 ? 32.452 -18.504 29.899 1.00 17.45 ? 85  VAL   B HG23 1 
ATOM   3659 N N    . TRP   B 1 106 ? 31.144 -18.810 26.475 1.00 13.64 ? 86  TRP   B N    1 
ATOM   3660 C CA   . TRP   B 1 106 ? 30.592 -17.530 26.081 1.00 13.07 ? 86  TRP   B CA   1 
ATOM   3661 C C    . TRP   B 1 106 ? 29.589 -17.079 27.137 1.00 15.12 ? 86  TRP   B C    1 
ATOM   3662 O O    . TRP   B 1 106 ? 28.744 -17.862 27.577 1.00 16.42 ? 86  TRP   B O    1 
ATOM   3663 C CB   . TRP   B 1 106 ? 29.877 -17.630 24.737 1.00 14.81 ? 86  TRP   B CB   1 
ATOM   3664 C CG   . TRP   B 1 106 ? 30.621 -18.307 23.655 1.00 12.80 ? 86  TRP   B CG   1 
ATOM   3665 C CD1  . TRP   B 1 106 ? 30.368 -19.536 23.136 1.00 15.36 ? 86  TRP   B CD1  1 
ATOM   3666 C CD2  . TRP   B 1 106 ? 31.713 -17.770 22.907 1.00 11.37 ? 86  TRP   B CD2  1 
ATOM   3667 N NE1  . TRP   B 1 106 ? 31.237 -19.808 22.112 1.00 15.05 ? 86  TRP   B NE1  1 
ATOM   3668 C CE2  . TRP   B 1 106 ? 32.081 -18.741 21.954 1.00 13.30 ? 86  TRP   B CE2  1 
ATOM   3669 C CE3  . TRP   B 1 106 ? 32.429 -16.567 22.956 1.00 14.21 ? 86  TRP   B CE3  1 
ATOM   3670 C CZ2  . TRP   B 1 106 ? 33.127 -18.545 21.058 1.00 15.07 ? 86  TRP   B CZ2  1 
ATOM   3671 C CZ3  . TRP   B 1 106 ? 33.463 -16.373 22.065 1.00 13.37 ? 86  TRP   B CZ3  1 
ATOM   3672 C CH2  . TRP   B 1 106 ? 33.804 -17.359 21.125 1.00 13.65 ? 86  TRP   B CH2  1 
ATOM   3673 H H    . TRP   B 1 106 ? 30.678 -19.480 26.204 1.00 16.39 ? 86  TRP   B H    1 
ATOM   3674 H HA   . TRP   B 1 106 ? 31.307 -16.879 25.999 1.00 15.70 ? 86  TRP   B HA   1 
ATOM   3675 H HB2  . TRP   B 1 106 ? 29.052 -18.124 24.869 1.00 17.78 ? 86  TRP   B HB2  1 
ATOM   3676 H HB3  . TRP   B 1 106 ? 29.681 -16.731 24.430 1.00 17.78 ? 86  TRP   B HB3  1 
ATOM   3677 H HD1  . TRP   B 1 106 ? 29.701 -20.111 23.433 1.00 18.45 ? 86  TRP   B HD1  1 
ATOM   3678 H HE1  . TRP   B 1 106 ? 31.251 -20.530 21.645 1.00 18.07 ? 86  TRP   B HE1  1 
ATOM   3679 H HE3  . TRP   B 1 106 ? 32.211 -15.911 23.579 1.00 17.06 ? 86  TRP   B HE3  1 
ATOM   3680 H HZ2  . TRP   B 1 106 ? 33.358 -19.198 20.437 1.00 18.10 ? 86  TRP   B HZ2  1 
ATOM   3681 H HZ3  . TRP   B 1 106 ? 33.943 -15.577 22.086 1.00 16.06 ? 86  TRP   B HZ3  1 
ATOM   3682 H HH2  . TRP   B 1 106 ? 34.505 -17.201 20.534 1.00 16.39 ? 86  TRP   B HH2  1 
ATOM   3683 N N    . THR   B 1 107 ? 29.662 -15.813 27.523 1.00 14.69 ? 87  THR   B N    1 
ATOM   3684 C CA   . THR   B 1 107 ? 28.726 -15.266 28.493 1.00 16.52 ? 87  THR   B CA   1 
ATOM   3685 C C    . THR   B 1 107 ? 28.268 -13.890 28.028 1.00 15.87 ? 87  THR   B C    1 
ATOM   3686 O O    . THR   B 1 107 ? 28.764 -13.336 27.044 1.00 15.30 ? 87  THR   B O    1 
ATOM   3687 C CB   . THR   B 1 107 ? 29.326 -15.155 29.887 1.00 18.59 ? 87  THR   B CB   1 
ATOM   3688 O OG1  . THR   B 1 107 ? 30.504 -14.368 29.824 1.00 18.49 ? 87  THR   B OG1  1 
ATOM   3689 C CG2  . THR   B 1 107 ? 29.632 -16.542 30.461 1.00 21.04 ? 87  THR   B CG2  1 
ATOM   3690 H H    . THR   B 1 107 ? 30.246 -15.250 27.237 1.00 17.64 ? 87  THR   B H    1 
ATOM   3691 H HA   . THR   B 1 107 ? 27.962 -15.861 28.536 1.00 19.84 ? 87  THR   B HA   1 
ATOM   3692 H HB   . THR   B 1 107 ? 28.694 -14.731 30.489 1.00 22.32 ? 87  THR   B HB   1 
ATOM   3693 H HG1  . THR   B 1 107 ? 31.182 -14.861 29.876 1.00 22.20 ? 87  THR   B HG1  1 
ATOM   3694 H HG21 . THR   B 1 107 ? 29.747 -16.486 31.422 1.00 25.26 ? 87  THR   B HG21 1 
ATOM   3695 H HG22 . THR   B 1 107 ? 28.901 -17.150 30.266 1.00 25.26 ? 87  THR   B HG22 1 
ATOM   3696 H HG23 . THR   B 1 107 ? 30.446 -16.893 30.066 1.00 25.26 ? 87  THR   B HG23 1 
ATOM   3697 N N    . ASP   B 1 108 ? 27.341 -13.317 28.788 1.00 15.86 ? 88  ASP   B N    1 
ATOM   3698 C CA   . ASP   B 1 108 ? 26.752 -12.021 28.458 1.00 15.98 ? 88  ASP   B CA   1 
ATOM   3699 C C    . ASP   B 1 108 ? 26.316 -11.999 27.001 1.00 14.16 ? 88  ASP   B C    1 
ATOM   3700 O O    . ASP   B 1 108 ? 26.599 -11.062 26.252 1.00 14.41 ? 88  ASP   B O    1 
ATOM   3701 C CB   . ASP   B 1 108 ? 27.722 -10.888 28.754 1.00 15.33 ? 88  ASP   B CB   1 
ATOM   3702 C CG   . ASP   B 1 108 ? 27.015 -9.572  28.951 1.00 36.50 ? 88  ASP   B CG   1 
ATOM   3703 O OD1  . ASP   B 1 108 ? 25.793 -9.601  29.205 1.00 35.47 ? 88  ASP   B OD1  1 
ATOM   3704 O OD2  . ASP   B 1 108 ? 27.662 -8.513  28.840 1.00 33.23 ? 88  ASP   B OD2  1 
ATOM   3705 H H    . ASP   B 1 108 ? 27.031 -13.663 29.512 1.00 19.05 ? 88  ASP   B H    1 
ATOM   3706 H HA   . ASP   B 1 108 ? 25.967 -11.887 29.012 1.00 19.19 ? 88  ASP   B HA   1 
ATOM   3707 H HB2  . ASP   B 1 108 ? 28.213 -11.091 29.566 1.00 18.41 ? 88  ASP   B HB2  1 
ATOM   3708 H HB3  . ASP   B 1 108 ? 28.337 -10.792 28.010 1.00 18.41 ? 88  ASP   B HB3  1 
ATOM   3709 N N    . ILE   B 1 109 ? 25.606 -13.047 26.614 1.00 15.39 ? 89  ILE   B N    1 
ATOM   3710 C CA   . ILE   B 1 109 ? 25.257 -13.291 25.218 1.00 14.94 ? 89  ILE   B CA   1 
ATOM   3711 C C    . ILE   B 1 109 ? 24.070 -12.423 24.849 1.00 16.89 ? 89  ILE   B C    1 
ATOM   3712 O O    . ILE   B 1 109 ? 22.992 -12.538 25.442 1.00 17.45 ? 89  ILE   B O    1 
ATOM   3713 C CB   . ILE   B 1 109 ? 24.945 -14.771 24.988 1.00 15.26 ? 89  ILE   B CB   1 
ATOM   3714 C CG1  . ILE   B 1 109 ? 26.209 -15.607 25.221 1.00 17.11 ? 89  ILE   B CG1  1 
ATOM   3715 C CG2  . ILE   B 1 109 ? 24.396 -14.991 23.593 1.00 18.14 ? 89  ILE   B CG2  1 
ATOM   3716 C CD1  . ILE   B 1 109 ? 25.918 -17.032 25.625 1.00 16.47 ? 89  ILE   B CD1  1 
ATOM   3717 H H    . ILE   B 1 109 ? 25.305 -13.647 27.151 1.00 18.48 ? 89  ILE   B H    1 
ATOM   3718 H HA   . ILE   B 1 109 ? 26.005 -13.039 24.654 1.00 17.94 ? 89  ILE   B HA   1 
ATOM   3719 H HB   . ILE   B 1 109 ? 24.266 -15.052 25.620 1.00 18.32 ? 89  ILE   B HB   1 
ATOM   3720 H HG12 . ILE   B 1 109 ? 26.726 -15.630 24.400 1.00 20.55 ? 89  ILE   B HG12 1 
ATOM   3721 H HG13 . ILE   B 1 109 ? 26.730 -15.197 25.929 1.00 20.55 ? 89  ILE   B HG13 1 
ATOM   3722 H HG21 . ILE   B 1 109 ? 24.477 -15.931 23.366 1.00 21.78 ? 89  ILE   B HG21 1 
ATOM   3723 H HG22 . ILE   B 1 109 ? 23.464 -14.726 23.575 1.00 21.78 ? 89  ILE   B HG22 1 
ATOM   3724 H HG23 . ILE   B 1 109 ? 24.905 -14.455 22.965 1.00 21.78 ? 89  ILE   B HG23 1 
ATOM   3725 H HD11 . ILE   B 1 109 ? 26.757 -17.495 25.775 1.00 19.78 ? 89  ILE   B HD11 1 
ATOM   3726 H HD12 . ILE   B 1 109 ? 25.392 -17.028 26.440 1.00 19.78 ? 89  ILE   B HD12 1 
ATOM   3727 H HD13 . ILE   B 1 109 ? 25.422 -17.467 24.913 1.00 19.78 ? 89  ILE   B HD13 1 
ATOM   3728 N N    . GLN   B 1 110 ? 24.265 -11.555 23.869 1.00 13.52 ? 90  GLN   B N    1 
ATOM   3729 C CA   . GLN   B 1 110 ? 23.207 -10.693 23.353 1.00 12.83 ? 90  GLN   B CA   1 
ATOM   3730 C C    . GLN   B 1 110 ? 23.011 -11.049 21.888 1.00 14.29 ? 90  GLN   B C    1 
ATOM   3731 O O    . GLN   B 1 110 ? 23.909 -10.830 21.063 1.00 14.98 ? 90  GLN   B O    1 
ATOM   3732 C CB   . GLN   B 1 110 ? 23.559 -9.221  23.487 1.00 14.03 ? 90  GLN   B CB   1 
ATOM   3733 C CG   . GLN   B 1 110 ? 23.879 -8.763  24.883 1.00 21.69 ? 90  GLN   B CG   1 
ATOM   3734 C CD   . GLN   B 1 110 ? 24.003 -7.263  24.944 1.00 32.55 ? 90  GLN   B CD   1 
ATOM   3735 O OE1  . GLN   B 1 110 ? 23.006 -6.552  25.065 1.00 34.95 ? 90  GLN   B OE1  1 
ATOM   3736 N NE2  . GLN   B 1 110 ? 25.228 -6.769  24.850 1.00 31.01 ? 90  GLN   B NE2  1 
ATOM   3737 H H    . GLN   B 1 110 ? 25.021 -11.442 23.475 1.00 16.24 ? 90  GLN   B H    1 
ATOM   3738 H HA   . GLN   B 1 110 ? 22.390 -10.856 23.851 1.00 15.41 ? 90  GLN   B HA   1 
ATOM   3739 H HB2  . GLN   B 1 110 ? 24.338 -9.042  22.938 1.00 16.84 ? 90  GLN   B HB2  1 
ATOM   3740 H HB3  . GLN   B 1 110 ? 22.805 -8.697  23.176 1.00 16.84 ? 90  GLN   B HB3  1 
ATOM   3741 H HG2  . GLN   B 1 110 ? 23.168 -9.037  25.484 1.00 26.05 ? 90  GLN   B HG2  1 
ATOM   3742 H HG3  . GLN   B 1 110 ? 24.721 -9.152  25.166 1.00 26.05 ? 90  GLN   B HG3  1 
ATOM   3743 H HE21 . GLN   B 1 110 ? 25.899 -7.299  24.760 1.00 37.23 ? 90  GLN   B HE21 1 
ATOM   3744 H HE22 . GLN   B 1 110 ? 25.352 -5.919  24.880 1.00 37.23 ? 90  GLN   B HE22 1 
ATOM   3745 N N    . ILE   B 1 111 ? 21.849 -11.594 21.557 1.00 15.70 ? 91  ILE   B N    1 
ATOM   3746 C CA   . ILE   B 1 111 ? 21.559 -12.065 20.207 1.00 12.43 ? 91  ILE   B CA   1 
ATOM   3747 C C    . ILE   B 1 111 ? 20.772 -10.992 19.478 1.00 13.26 ? 91  ILE   B C    1 
ATOM   3748 O O    . ILE   B 1 111 ? 19.751 -10.513 19.981 1.00 17.25 ? 91  ILE   B O    1 
ATOM   3749 C CB   . ILE   B 1 111 ? 20.790 -13.396 20.234 1.00 15.59 ? 91  ILE   B CB   1 
ATOM   3750 C CG1  . ILE   B 1 111 ? 21.660 -14.473 20.895 1.00 19.11 ? 91  ILE   B CG1  1 
ATOM   3751 C CG2  . ILE   B 1 111 ? 20.392 -13.796 18.828 1.00 16.31 ? 91  ILE   B CG2  1 
ATOM   3752 C CD1  . ILE   B 1 111 ? 20.966 -15.803 21.091 1.00 19.55 ? 91  ILE   B CD1  1 
ATOM   3753 H H    . ILE   B 1 111 ? 21.198 -11.705 22.108 1.00 18.85 ? 91  ILE   B H    1 
ATOM   3754 H HA   . ILE   B 1 111 ? 22.393 -12.206 19.731 1.00 14.93 ? 91  ILE   B HA   1 
ATOM   3755 H HB   . ILE   B 1 111 ? 19.979 -13.292 20.756 1.00 18.72 ? 91  ILE   B HB   1 
ATOM   3756 H HG12 . ILE   B 1 111 ? 22.438 -14.628 20.336 1.00 22.94 ? 91  ILE   B HG12 1 
ATOM   3757 H HG13 . ILE   B 1 111 ? 21.937 -14.155 21.768 1.00 22.94 ? 91  ILE   B HG13 1 
ATOM   3758 H HG21 . ILE   B 1 111 ? 20.080 -14.714 18.837 1.00 19.58 ? 91  ILE   B HG21 1 
ATOM   3759 H HG22 . ILE   B 1 111 ? 19.684 -13.209 18.521 1.00 19.58 ? 91  ILE   B HG22 1 
ATOM   3760 H HG23 . ILE   B 1 111 ? 21.164 -13.715 18.246 1.00 19.58 ? 91  ILE   B HG23 1 
ATOM   3761 H HD11 . ILE   B 1 111 ? 21.536 -16.382 21.621 1.00 23.47 ? 91  ILE   B HD11 1 
ATOM   3762 H HD12 . ILE   B 1 111 ? 20.125 -15.655 21.552 1.00 23.47 ? 91  ILE   B HD12 1 
ATOM   3763 H HD13 . ILE   B 1 111 ? 20.801 -16.205 20.224 1.00 23.47 ? 91  ILE   B HD13 1 
ATOM   3764 N N    . PHE   B 1 112 ? 21.240 -10.626 18.285 1.00 14.67 ? 92  PHE   B N    1 
ATOM   3765 C CA   . PHE   B 1 112 ? 20.574 -9.639  17.452 1.00 15.09 ? 92  PHE   B CA   1 
ATOM   3766 C C    . PHE   B 1 112 ? 20.045 -10.314 16.195 1.00 14.68 ? 92  PHE   B C    1 
ATOM   3767 O O    . PHE   B 1 112 ? 20.819 -10.764 15.344 1.00 14.35 ? 92  PHE   B O    1 
ATOM   3768 C CB   . PHE   B 1 112 ? 21.522 -8.500  17.103 1.00 14.57 ? 92  PHE   B CB   1 
ATOM   3769 C CG   . PHE   B 1 112 ? 22.001 -7.766  18.296 1.00 13.47 ? 92  PHE   B CG   1 
ATOM   3770 C CD1  . PHE   B 1 112 ? 21.236 -6.740  18.833 1.00 13.30 ? 92  PHE   B CD1  1 
ATOM   3771 C CD2  . PHE   B 1 112 ? 23.182 -8.116  18.917 1.00 15.04 ? 92  PHE   B CD2  1 
ATOM   3772 C CE1  . PHE   B 1 112 ? 21.658 -6.070  19.956 1.00 18.03 ? 92  PHE   B CE1  1 
ATOM   3773 C CE2  . PHE   B 1 112 ? 23.611 -7.445  20.040 1.00 15.46 ? 92  PHE   B CE2  1 
ATOM   3774 C CZ   . PHE   B 1 112 ? 22.845 -6.422  20.562 1.00 15.56 ? 92  PHE   B CZ   1 
ATOM   3775 H H    . PHE   B 1 112 ? 21.958 -10.944 17.934 1.00 17.61 ? 92  PHE   B H    1 
ATOM   3776 H HA   . PHE   B 1 112 ? 19.814 -9.280  17.937 1.00 18.12 ? 92  PHE   B HA   1 
ATOM   3777 H HB2  . PHE   B 1 112 ? 22.296 -8.864  16.644 1.00 17.50 ? 92  PHE   B HB2  1 
ATOM   3778 H HB3  . PHE   B 1 112 ? 21.061 -7.870  16.528 1.00 17.50 ? 92  PHE   B HB3  1 
ATOM   3779 H HD1  . PHE   B 1 112 ? 20.432 -6.505  18.430 1.00 15.97 ? 92  PHE   B HD1  1 
ATOM   3780 H HD2  . PHE   B 1 112 ? 23.694 -8.813  18.574 1.00 18.06 ? 92  PHE   B HD2  1 
ATOM   3781 H HE1  . PHE   B 1 112 ? 21.143 -5.379  20.306 1.00 21.65 ? 92  PHE   B HE1  1 
ATOM   3782 H HE2  . PHE   B 1 112 ? 24.414 -7.680  20.446 1.00 18.57 ? 92  PHE   B HE2  1 
ATOM   3783 H HZ   . PHE   B 1 112 ? 23.130 -5.969  21.323 1.00 18.69 ? 92  PHE   B HZ   1 
ATOM   3784 N N    . GLU   B 1 113 ? 18.727 -10.394 16.088 1.00 14.27 ? 93  GLU   B N    1 
ATOM   3785 C CA   . GLU   B 1 113 ? 18.098 -10.633 14.805 1.00 14.66 ? 93  GLU   B CA   1 
ATOM   3786 C C    . GLU   B 1 113 ? 18.331 -9.416  13.917 1.00 15.92 ? 93  GLU   B C    1 
ATOM   3787 O O    . GLU   B 1 113 ? 18.682 -8.336  14.393 1.00 16.98 ? 93  GLU   B O    1 
ATOM   3788 C CB   . GLU   B 1 113 ? 16.594 -10.864 14.971 1.00 22.32 ? 93  GLU   B CB   1 
ATOM   3789 C CG   . GLU   B 1 113 ? 16.234 -11.957 15.942 1.00 30.87 ? 93  GLU   B CG   1 
ATOM   3790 C CD   . GLU   B 1 113 ? 14.791 -11.832 16.401 1.00 28.19 ? 93  GLU   B CD   1 
ATOM   3791 O OE1  . GLU   B 1 113 ? 14.062 -11.009 15.810 1.00 30.35 ? 93  GLU   B OE1  1 
ATOM   3792 O OE2  . GLU   B 1 113 ? 14.407 -12.542 17.349 1.00 43.65 ? 93  GLU   B OE2  1 
ATOM   3793 H H    . GLU   B 1 113 ? 18.176 -10.313 16.744 1.00 17.13 ? 93  GLU   B H    1 
ATOM   3794 H HA   . GLU   B 1 113 ? 18.472 -11.425 14.388 1.00 17.61 ? 93  GLU   B HA   1 
ATOM   3795 H HB2  . GLU   B 1 113 ? 16.188 -10.043 15.291 1.00 26.80 ? 93  GLU   B HB2  1 
ATOM   3796 H HB3  . GLU   B 1 113 ? 16.221 -11.104 14.109 1.00 26.80 ? 93  GLU   B HB3  1 
ATOM   3797 H HG2  . GLU   B 1 113 ? 16.345 -12.820 15.512 1.00 37.06 ? 93  GLU   B HG2  1 
ATOM   3798 H HG3  . GLU   B 1 113 ? 16.810 -11.899 16.721 1.00 37.06 ? 93  GLU   B HG3  1 
ATOM   3799 N N    . THR   B 1 114 ? 18.157 -9.591  12.614 1.00 14.62 ? 94  THR   B N    1 
ATOM   3800 C CA   . THR   B 1 114 ? 18.255 -8.473  11.691 1.00 12.54 ? 94  THR   B CA   1 
ATOM   3801 C C    . THR   B 1 114 ? 17.105 -8.550  10.695 1.00 15.90 ? 94  THR   B C    1 
ATOM   3802 O O    . THR   B 1 114 ? 16.283 -9.470  10.730 1.00 16.98 ? 94  THR   B O    1 
ATOM   3803 C CB   . THR   B 1 114 ? 19.589 -8.431  10.940 1.00 14.92 ? 94  THR   B CB   1 
ATOM   3804 O OG1  . THR   B 1 114 ? 19.611 -9.413  9.902  1.00 15.53 ? 94  THR   B OG1  1 
ATOM   3805 C CG2  . THR   B 1 114 ? 20.759 -8.654  11.888 1.00 15.69 ? 94  THR   B CG2  1 
ATOM   3806 H H    . THR   B 1 114 ? 17.983 -10.347 12.243 1.00 17.55 ? 94  THR   B H    1 
ATOM   3807 H HA   . THR   B 1 114 ? 18.179 -7.663  12.220 1.00 15.06 ? 94  THR   B HA   1 
ATOM   3808 H HB   . THR   B 1 114 ? 19.691 -7.553  10.539 1.00 17.92 ? 94  THR   B HB   1 
ATOM   3809 H HG1  . THR   B 1 114 ? 19.462 -10.175 10.225 1.00 18.65 ? 94  THR   B HG1  1 
ATOM   3810 H HG21 . THR   B 1 114 ? 21.596 -8.601  11.400 1.00 18.84 ? 94  THR   B HG21 1 
ATOM   3811 H HG22 . THR   B 1 114 ? 20.757 -7.977  12.583 1.00 18.84 ? 94  THR   B HG22 1 
ATOM   3812 H HG23 . THR   B 1 114 ? 20.690 -9.529  12.300 1.00 18.84 ? 94  THR   B HG23 1 
ATOM   3813 N N    . GLN   B 1 115 ? 17.063 -7.575  9.788  1.00 15.39 ? 95  GLN   B N    1 
ATOM   3814 C CA   . GLN   B 1 115 ? 16.046 -7.585  8.741  1.00 17.13 ? 95  GLN   B CA   1 
ATOM   3815 C C    . GLN   B 1 115 ? 16.219 -8.766  7.799  1.00 19.55 ? 95  GLN   B C    1 
ATOM   3816 O O    . GLN   B 1 115 ? 15.283 -9.102  7.061  1.00 20.92 ? 95  GLN   B O    1 
ATOM   3817 C CB   . GLN   B 1 115 ? 16.080 -6.280  7.943  1.00 17.60 ? 95  GLN   B CB   1 
ATOM   3818 C CG   . GLN   B 1 115 ? 17.302 -6.093  7.062  1.00 15.66 ? 95  GLN   B CG   1 
ATOM   3819 C CD   . GLN   B 1 115 ? 18.394 -5.309  7.753  1.00 20.24 ? 95  GLN   B CD   1 
ATOM   3820 O OE1  . GLN   B 1 115 ? 18.622 -5.481  8.941  1.00 16.59 ? 95  GLN   B OE1  1 
ATOM   3821 N NE2  . GLN   B 1 115 ? 19.058 -4.425  7.013  1.00 25.67 ? 95  GLN   B NE2  1 
ATOM   3822 H H    . GLN   B 1 115 ? 17.603 -6.907  9.757  1.00 18.49 ? 95  GLN   B H    1 
ATOM   3823 H HA   . GLN   B 1 115 ? 15.174 -7.650  9.160  1.00 20.57 ? 95  GLN   B HA   1 
ATOM   3824 H HB2  . GLN   B 1 115 ? 15.300 -6.253  7.367  1.00 21.13 ? 95  GLN   B HB2  1 
ATOM   3825 H HB3  . GLN   B 1 115 ? 16.057 -5.539  8.568  1.00 21.13 ? 95  GLN   B HB3  1 
ATOM   3826 H HG2  . GLN   B 1 115 ? 17.659 -6.963  6.825  1.00 18.80 ? 95  GLN   B HG2  1 
ATOM   3827 H HG3  . GLN   B 1 115 ? 17.045 -5.611  6.261  1.00 18.80 ? 95  GLN   B HG3  1 
ATOM   3828 H HE21 . GLN   B 1 115 ? 18.857 -4.322  6.183  1.00 30.82 ? 95  GLN   B HE21 1 
ATOM   3829 H HE22 . GLN   B 1 115 ? 19.687 -3.956  7.365  1.00 30.82 ? 95  GLN   B HE22 1 
ATOM   3830 N N    . ASP   B 1 116 ? 17.411 -9.372  7.771  1.00 16.20 ? 96  ASP   B N    1 
ATOM   3831 C CA   . ASP   B 1 116 ? 17.654 -10.581 6.999  1.00 17.01 ? 96  ASP   B CA   1 
ATOM   3832 C C    . ASP   B 1 116 ? 17.384 -11.749 7.924  1.00 16.91 ? 96  ASP   B C    1 
ATOM   3833 O O    . ASP   B 1 116 ? 18.106 -11.916 8.910  1.00 15.64 ? 96  ASP   B O    1 
ATOM   3834 C CB   . ASP   B 1 116 ? 19.091 -10.597 6.496  1.00 18.18 ? 96  ASP   B CB   1 
ATOM   3835 C CG   . ASP   B 1 116 ? 19.412 -11.805 5.641  1.00 17.50 ? 96  ASP   B CG   1 
ATOM   3836 O OD1  . ASP   B 1 116 ? 18.659 -12.809 5.685  1.00 19.09 ? 96  ASP   B OD1  1 
ATOM   3837 O OD2  . ASP   B 1 116 ? 20.436 -11.754 4.942  1.00 21.02 ? 96  ASP   B OD2  1 
ATOM   3838 H H    . ASP   B 1 116 ? 18.102 -9.093  8.201  1.00 19.45 ? 96  ASP   B H    1 
ATOM   3839 H HA   . ASP   B 1 116 ? 17.068 -10.638 6.228  1.00 20.42 ? 96  ASP   B HA   1 
ATOM   3840 H HB2  . ASP   B 1 116 ? 19.245 -9.803  5.960  1.00 21.83 ? 96  ASP   B HB2  1 
ATOM   3841 H HB3  . ASP   B 1 116 ? 19.691 -10.603 7.258  1.00 21.83 ? 96  ASP   B HB3  1 
ATOM   3842 N N    . PRO   B 1 117 ? 16.338 -12.554 7.691  1.00 16.15 ? 97  PRO   B N    1 
ATOM   3843 C CA   . PRO   B 1 117 ? 16.045 -13.655 8.622  1.00 17.06 ? 97  PRO   B CA   1 
ATOM   3844 C C    . PRO   B 1 117 ? 17.186 -14.645 8.733  1.00 15.99 ? 97  PRO   B C    1 
ATOM   3845 O O    . PRO   B 1 117 ? 17.240 -15.413 9.697  1.00 17.68 ? 97  PRO   B O    1 
ATOM   3846 C CB   . PRO   B 1 117 ? 14.785 -14.309 8.023  1.00 22.49 ? 97  PRO   B CB   1 
ATOM   3847 C CG   . PRO   B 1 117 ? 14.772 -13.881 6.585  1.00 25.25 ? 97  PRO   B CG   1 
ATOM   3848 C CD   . PRO   B 1 117 ? 15.396 -12.515 6.555  1.00 19.68 ? 97  PRO   B CD   1 
ATOM   3849 H HA   . PRO   B 1 117 ? 15.825 -13.307 9.500  1.00 20.49 ? 97  PRO   B HA   1 
ATOM   3850 H HB2  . PRO   B 1 117 ? 14.848 -15.274 8.097  1.00 27.00 ? 97  PRO   B HB2  1 
ATOM   3851 H HB3  . PRO   B 1 117 ? 13.996 -13.990 8.487  1.00 27.00 ? 97  PRO   B HB3  1 
ATOM   3852 H HG2  . PRO   B 1 117 ? 15.288 -14.507 6.054  1.00 30.31 ? 97  PRO   B HG2  1 
ATOM   3853 H HG3  . PRO   B 1 117 ? 13.857 -13.848 6.263  1.00 30.31 ? 97  PRO   B HG3  1 
ATOM   3854 H HD2  . PRO   B 1 117 ? 15.868 -12.368 5.720  1.00 23.62 ? 97  PRO   B HD2  1 
ATOM   3855 H HD3  . PRO   B 1 117 ? 14.727 -11.825 6.684  1.00 23.62 ? 97  PRO   B HD3  1 
ATOM   3856 N N    . ASN   B 1 118 ? 18.110 -14.631 7.777  1.00 17.75 ? 98  ASN   B N    1 
ATOM   3857 C CA   . ASN   B 1 118 ? 19.230 -15.547 7.753  1.00 16.37 ? 98  ASN   B CA   1 
ATOM   3858 C C    . ASN   B 1 118 ? 20.536 -14.890 8.160  1.00 16.41 ? 98  ASN   B C    1 
ATOM   3859 O O    . ASN   B 1 118 ? 21.601 -15.433 7.870  1.00 16.03 ? 98  ASN   B O    1 
ATOM   3860 C CB   . ASN   B 1 118 ? 19.375 -16.147 6.365  1.00 18.32 ? 98  ASN   B CB   1 
ATOM   3861 C CG   . ASN   B 1 118 ? 18.243 -17.066 6.029  1.00 20.99 ? 98  ASN   B CG   1 
ATOM   3862 O OD1  . ASN   B 1 118 ? 18.024 -18.064 6.713  1.00 19.09 ? 98  ASN   B OD1  1 
ATOM   3863 N ND2  . ASN   B 1 118 ? 17.498 -16.727 4.984  1.00 26.97 ? 98  ASN   B ND2  1 
ATOM   3864 H H    . ASN   B 1 118 ? 18.103 -14.081 7.115  1.00 21.32 ? 98  ASN   B H    1 
ATOM   3865 H HA   . ASN   B 1 118 ? 19.048 -16.260 8.384  1.00 19.65 ? 98  ASN   B HA   1 
ATOM   3866 H HB2  . ASN   B 1 118 ? 19.390 -15.432 5.709  1.00 21.99 ? 98  ASN   B HB2  1 
ATOM   3867 H HB3  . ASN   B 1 118 ? 20.200 -16.654 6.322  1.00 21.99 ? 98  ASN   B HB3  1 
ATOM   3868 H HD21 . ASN   B 1 118 ? 16.835 -17.223 4.750  1.00 32.38 ? 98  ASN   B HD21 1 
ATOM   3869 H HD22 . ASN   B 1 118 ? 17.677 -16.012 4.541  1.00 32.38 ? 98  ASN   B HD22 1 
ATOM   3870 N N    . TRP   B 1 119 ? 20.482 -13.735 8.819  1.00 15.34 ? 99  TRP   B N    1 
ATOM   3871 C CA   . TRP   B 1 119 ? 21.697 -13.092 9.293  1.00 14.07 ? 99  TRP   B CA   1 
ATOM   3872 C C    . TRP   B 1 119 ? 21.476 -12.610 10.715 1.00 14.00 ? 99  TRP   B C    1 
ATOM   3873 O O    . TRP   B 1 119 ? 20.550 -11.844 10.981 1.00 14.77 ? 99  TRP   B O    1 
ATOM   3874 C CB   . TRP   B 1 119 ? 22.080 -11.937 8.375  1.00 14.10 ? 99  TRP   B CB   1 
ATOM   3875 C CG   . TRP   B 1 119 ? 23.508 -11.543 8.423  1.00 14.28 ? 99  TRP   B CG   1 
ATOM   3876 C CD1  . TRP   B 1 119 ? 24.368 -11.641 9.477  1.00 14.36 ? 99  TRP   B CD1  1 
ATOM   3877 C CD2  . TRP   B 1 119 ? 24.250 -10.979 7.346  1.00 14.42 ? 99  TRP   B CD2  1 
ATOM   3878 N NE1  . TRP   B 1 119 ? 25.610 -11.154 9.113  1.00 13.76 ? 99  TRP   B NE1  1 
ATOM   3879 C CE2  . TRP   B 1 119 ? 25.558 -10.751 7.804  1.00 15.69 ? 99  TRP   B CE2  1 
ATOM   3880 C CE3  . TRP   B 1 119 ? 23.929 -10.648 6.028  1.00 17.49 ? 99  TRP   B CE3  1 
ATOM   3881 C CZ2  . TRP   B 1 119 ? 26.543 -10.195 6.994  1.00 18.44 ? 99  TRP   B CZ2  1 
ATOM   3882 C CZ3  . TRP   B 1 119 ? 24.899 -10.105 5.231  1.00 16.65 ? 99  TRP   B CZ3  1 
ATOM   3883 C CH2  . TRP   B 1 119 ? 26.196 -9.879  5.709  1.00 19.92 ? 99  TRP   B CH2  1 
ATOM   3884 H H    . TRP   B 1 119 ? 19.757 -13.310 9.001  1.00 18.42 ? 99  TRP   B H    1 
ATOM   3885 H HA   . TRP   B 1 119 ? 22.426 -13.731 9.309  1.00 16.89 ? 99  TRP   B HA   1 
ATOM   3886 H HB2  . TRP   B 1 119 ? 21.880 -12.192 7.461  1.00 16.93 ? 99  TRP   B HB2  1 
ATOM   3887 H HB3  . TRP   B 1 119 ? 21.556 -11.160 8.625  1.00 16.93 ? 99  TRP   B HB3  1 
ATOM   3888 H HD1  . TRP   B 1 119 ? 24.152 -11.984 10.314 1.00 17.24 ? 99  TRP   B HD1  1 
ATOM   3889 H HE1  . TRP   B 1 119 ? 26.301 -11.112 9.623  1.00 16.53 ? 99  TRP   B HE1  1 
ATOM   3890 H HE3  . TRP   B 1 119 ? 23.071 -10.792 5.699  1.00 21.00 ? 99  TRP   B HE3  1 
ATOM   3891 H HZ2  . TRP   B 1 119 ? 27.403 -10.044 7.313  1.00 22.14 ? 99  TRP   B HZ2  1 
ATOM   3892 H HZ3  . TRP   B 1 119 ? 24.693 -9.882  4.352  1.00 20.00 ? 99  TRP   B HZ3  1 
ATOM   3893 H HH2  . TRP   B 1 119 ? 26.833 -9.508  5.142  1.00 23.92 ? 99  TRP   B HH2  1 
ATOM   3894 N N    . PHE   B 1 120 ? 22.322 -13.088 11.611 1.00 15.56 ? 100 PHE   B N    1 
ATOM   3895 C CA   . PHE   B 1 120 ? 22.312 -12.752 13.022 1.00 13.66 ? 100 PHE   B CA   1 
ATOM   3896 C C    . PHE   B 1 120 ? 23.676 -12.211 13.419 1.00 12.99 ? 100 PHE   B C    1 
ATOM   3897 O O    . PHE   B 1 120 ? 24.701 -12.595 12.854 1.00 14.05 ? 100 PHE   B O    1 
ATOM   3898 C CB   . PHE   B 1 120 ? 21.988 -13.976 13.897 1.00 13.77 ? 100 PHE   B CB   1 
ATOM   3899 C CG   . PHE   B 1 120 ? 20.532 -14.304 13.957 1.00 12.99 ? 100 PHE   B CG   1 
ATOM   3900 C CD1  . PHE   B 1 120 ? 19.881 -14.819 12.842 1.00 17.29 ? 100 PHE   B CD1  1 
ATOM   3901 C CD2  . PHE   B 1 120 ? 19.820 -14.116 15.118 1.00 16.71 ? 100 PHE   B CD2  1 
ATOM   3902 C CE1  . PHE   B 1 120 ? 18.537 -15.123 12.899 1.00 16.72 ? 100 PHE   B CE1  1 
ATOM   3903 C CE2  . PHE   B 1 120 ? 18.478 -14.422 15.187 1.00 20.25 ? 100 PHE   B CE2  1 
ATOM   3904 C CZ   . PHE   B 1 120 ? 17.842 -14.922 14.067 1.00 18.78 ? 100 PHE   B CZ   1 
ATOM   3905 H H    . PHE   B 1 120 ? 22.949 -13.643 11.414 1.00 18.69 ? 100 PHE   B H    1 
ATOM   3906 H HA   . PHE   B 1 120 ? 21.637 -12.074 13.185 1.00 16.40 ? 100 PHE   B HA   1 
ATOM   3907 H HB2  . PHE   B 1 120 ? 22.451 -14.749 13.536 1.00 16.54 ? 100 PHE   B HB2  1 
ATOM   3908 H HB3  . PHE   B 1 120 ? 22.290 -13.802 14.802 1.00 16.54 ? 100 PHE   B HB3  1 
ATOM   3909 H HD1  . PHE   B 1 120 ? 20.355 -14.960 12.054 1.00 20.76 ? 100 PHE   B HD1  1 
ATOM   3910 H HD2  . PHE   B 1 120 ? 20.251 -13.776 15.869 1.00 20.07 ? 100 PHE   B HD2  1 
ATOM   3911 H HE1  . PHE   B 1 120 ? 18.103 -15.462 12.149 1.00 20.08 ? 100 PHE   B HE1  1 
ATOM   3912 H HE2  . PHE   B 1 120 ? 18.006 -14.294 15.978 1.00 24.32 ? 100 PHE   B HE2  1 
ATOM   3913 H HZ   . PHE   B 1 120 ? 16.935 -15.125 14.104 1.00 22.55 ? 100 PHE   B HZ   1 
ATOM   3914 N N    . TRP   B 1 121 ? 23.671 -11.324 14.411 1.00 14.32 ? 101 TRP   B N    1 
ATOM   3915 C CA   . TRP   B 1 121 ? 24.866 -10.890 15.107 1.00 12.73 ? 101 TRP   B CA   1 
ATOM   3916 C C    . TRP   B 1 121 ? 24.709 -11.234 16.575 1.00 13.17 ? 101 TRP   B C    1 
ATOM   3917 O O    . TRP   B 1 121 ? 23.595 -11.247 17.102 1.00 13.79 ? 101 TRP   B O    1 
ATOM   3918 C CB   . TRP   B 1 121 ? 25.099 -9.388  14.938 1.00 12.71 ? 101 TRP   B CB   1 
ATOM   3919 C CG   . TRP   B 1 121 ? 25.478 -9.070  13.546 1.00 12.54 ? 101 TRP   B CG   1 
ATOM   3920 C CD1  . TRP   B 1 121 ? 24.636 -8.793  12.513 1.00 13.73 ? 101 TRP   B CD1  1 
ATOM   3921 C CD2  . TRP   B 1 121 ? 26.804 -9.017  13.019 1.00 12.57 ? 101 TRP   B CD2  1 
ATOM   3922 N NE1  . TRP   B 1 121 ? 25.357 -8.566  11.366 1.00 15.84 ? 101 TRP   B NE1  1 
ATOM   3923 C CE2  . TRP   B 1 121 ? 26.692 -8.698  11.651 1.00 13.83 ? 101 TRP   B CE2  1 
ATOM   3924 C CE3  . TRP   B 1 121 ? 28.073 -9.205  13.565 1.00 11.29 ? 101 TRP   B CE3  1 
ATOM   3925 C CZ2  . TRP   B 1 121 ? 27.805 -8.561  10.823 1.00 12.63 ? 101 TRP   B CZ2  1 
ATOM   3926 C CZ3  . TRP   B 1 121 ? 29.176 -9.061  12.747 1.00 12.78 ? 101 TRP   B CZ3  1 
ATOM   3927 C CH2  . TRP   B 1 121 ? 29.038 -8.745  11.389 1.00 12.32 ? 101 TRP   B CH2  1 
ATOM   3928 H H    . TRP   B 1 121 ? 22.957 -10.948 14.707 1.00 17.20 ? 101 TRP   B H    1 
ATOM   3929 H HA   . TRP   B 1 121 ? 25.649 -11.342 14.755 1.00 15.29 ? 101 TRP   B HA   1 
ATOM   3930 H HB2  . TRP   B 1 121 ? 24.284 -8.908  15.153 1.00 15.27 ? 101 TRP   B HB2  1 
ATOM   3931 H HB3  . TRP   B 1 121 ? 25.816 -9.103  15.526 1.00 15.27 ? 101 TRP   B HB3  1 
ATOM   3932 H HD1  . TRP   B 1 121 ? 23.708 -8.761  12.575 1.00 16.48 ? 101 TRP   B HD1  1 
ATOM   3933 H HE1  . TRP   B 1 121 ? 25.026 -8.374  10.596 1.00 19.02 ? 101 TRP   B HE1  1 
ATOM   3934 H HE3  . TRP   B 1 121 ? 28.175 -9.423  14.463 1.00 13.56 ? 101 TRP   B HE3  1 
ATOM   3935 H HZ2  . TRP   B 1 121 ? 27.713 -8.351  9.921  1.00 15.17 ? 101 TRP   B HZ2  1 
ATOM   3936 H HZ3  . TRP   B 1 121 ? 30.027 -9.175  13.104 1.00 15.35 ? 101 TRP   B HZ3  1 
ATOM   3937 H HH2  . TRP   B 1 121 ? 29.798 -8.660  10.861 1.00 14.80 ? 101 TRP   B HH2  1 
ATOM   3938 N N    . VAL   B 1 122 ? 25.826 -11.530 17.224 1.00 12.82 ? 102 VAL   B N    1 
ATOM   3939 C CA   . VAL   B 1 122 ? 25.863 -11.785 18.656 1.00 10.91 ? 102 VAL   B CA   1 
ATOM   3940 C C    . VAL   B 1 122 ? 26.969 -10.928 19.238 1.00 12.01 ? 102 VAL   B C    1 
ATOM   3941 O O    . VAL   B 1 122 ? 28.084 -10.906 18.707 1.00 14.66 ? 102 VAL   B O    1 
ATOM   3942 C CB   . VAL   B 1 122 ? 26.126 -13.265 18.982 1.00 13.58 ? 102 VAL   B CB   1 
ATOM   3943 C CG1  . VAL   B 1 122 ? 26.291 -13.467 20.483 1.00 15.98 ? 102 VAL   B CG1  1 
ATOM   3944 C CG2  . VAL   B 1 122 ? 24.994 -14.122 18.435 1.00 15.25 ? 102 VAL   B CG2  1 
ATOM   3945 H H    . VAL   B 1 122 ? 26.596 -11.590 16.846 1.00 15.39 ? 102 VAL   B H    1 
ATOM   3946 H HA   . VAL   B 1 122 ? 25.012 -11.537 19.049 1.00 13.11 ? 102 VAL   B HA   1 
ATOM   3947 H HB   . VAL   B 1 122 ? 26.953 -13.545 18.559 1.00 16.31 ? 102 VAL   B HB   1 
ATOM   3948 H HG11 . VAL   B 1 122 ? 26.217 -14.412 20.684 1.00 19.18 ? 102 VAL   B HG11 1 
ATOM   3949 H HG12 . VAL   B 1 122 ? 27.164 -13.139 20.751 1.00 19.18 ? 102 VAL   B HG12 1 
ATOM   3950 H HG13 . VAL   B 1 122 ? 25.596 -12.974 20.946 1.00 19.18 ? 102 VAL   B HG13 1 
ATOM   3951 H HG21 . VAL   B 1 122 ? 25.185 -15.055 18.623 1.00 18.32 ? 102 VAL   B HG21 1 
ATOM   3952 H HG22 . VAL   B 1 122 ? 24.165 -13.862 18.864 1.00 18.32 ? 102 VAL   B HG22 1 
ATOM   3953 H HG23 . VAL   B 1 122 ? 24.929 -13.985 17.477 1.00 18.32 ? 102 VAL   B HG23 1 
ATOM   3954 N N    . GLU   B 1 123 ? 26.664 -10.211 20.312 1.00 11.92 ? 103 GLU   B N    1 
ATOM   3955 C CA   . GLU   B 1 123 ? 27.682 -9.566  21.123 1.00 11.56 ? 103 GLU   B CA   1 
ATOM   3956 C C    . GLU   B 1 123 ? 27.814 -10.371 22.400 1.00 11.21 ? 103 GLU   B C    1 
ATOM   3957 O O    . GLU   B 1 123 ? 26.807 -10.707 23.021 1.00 13.81 ? 103 GLU   B O    1 
ATOM   3958 C CB   . GLU   B 1 123 ? 27.343 -8.106  21.437 1.00 12.30 ? 103 GLU   B CB   1 
ATOM   3959 C CG   . GLU   B 1 123 ? 28.441 -7.462  22.249 1.00 12.20 ? 103 GLU   B CG   1 
ATOM   3960 C CD   . GLU   B 1 123 ? 28.207 -6.003  22.555 1.00 15.70 ? 103 GLU   B CD   1 
ATOM   3961 O OE1  . GLU   B 1 123 ? 27.125 -5.467  22.219 1.00 14.57 ? 103 GLU   B OE1  1 
ATOM   3962 O OE2  . GLU   B 1 123 ? 29.129 -5.393  23.129 1.00 18.03 ? 103 GLU   B OE2  1 
ATOM   3963 H H    . GLU   B 1 123 ? 25.861 -10.083 20.594 1.00 14.32 ? 103 GLU   B H    1 
ATOM   3964 H HA   . GLU   B 1 123 ? 28.528 -9.553  20.648 1.00 13.88 ? 103 GLU   B HA   1 
ATOM   3965 H HB2  . GLU   B 1 123 ? 27.242 -7.613  20.608 1.00 14.77 ? 103 GLU   B HB2  1 
ATOM   3966 H HB3  . GLU   B 1 123 ? 26.519 -8.068  21.947 1.00 14.77 ? 103 GLU   B HB3  1 
ATOM   3967 H HG2  . GLU   B 1 123 ? 28.519 -7.932  23.094 1.00 14.65 ? 103 GLU   B HG2  1 
ATOM   3968 H HG3  . GLU   B 1 123 ? 29.273 -7.529  21.755 1.00 14.65 ? 103 GLU   B HG3  1 
ATOM   3969 N N    . CYS   B 1 124 ? 29.038 -10.688 22.788 1.00 11.77 ? 104 CYS   B N    1 
ATOM   3970 C CA   . CYS   B 1 124 ? 29.209 -11.471 23.999 1.00 12.03 ? 104 CYS   B CA   1 
ATOM   3971 C C    . CYS   B 1 124 ? 30.627 -11.321 24.523 1.00 11.32 ? 104 CYS   B C    1 
ATOM   3972 O O    . CYS   B 1 124 ? 31.483 -10.668 23.926 1.00 13.47 ? 104 CYS   B O    1 
ATOM   3973 C CB   . CYS   B 1 124 ? 28.885 -12.941 23.751 1.00 13.14 ? 104 CYS   B CB   1 
ATOM   3974 S SG   . CYS   B 1 124 ? 30.091 -13.812 22.721 1.00 15.19 ? 104 CYS   B SG   1 
ATOM   3975 H H    . CYS   B 1 124 ? 29.763 -10.469 22.379 1.00 14.14 ? 104 CYS   B H    1 
ATOM   3976 H HA   . CYS   B 1 124 ? 28.610 -11.117 24.674 1.00 14.45 ? 104 CYS   B HA   1 
ATOM   3977 H HB2  . CYS   B 1 124 ? 28.847 -13.398 24.606 1.00 15.79 ? 104 CYS   B HB2  1 
ATOM   3978 H HB3  . CYS   B 1 124 ? 28.025 -12.997 23.306 1.00 15.79 ? 104 CYS   B HB3  1 
ATOM   3979 H HG   . CYS   B 1 124 ? 31.195 -13.571 23.123 1.00 18.24 ? 104 CYS   B HG   1 
ATOM   3980 N N    . ARG   B 1 125 ? 30.847 -11.919 25.686 1.00 12.81 ? 105 ARG   B N    1 
ATOM   3981 C CA   . ARG   B 1 125 ? 32.180 -12.137 26.210 1.00 13.22 ? 105 ARG   B CA   1 
ATOM   3982 C C    . ARG   B 1 125 ? 32.533 -13.606 26.040 1.00 12.75 ? 105 ARG   B C    1 
ATOM   3983 O O    . ARG   B 1 125 ? 31.664 -14.469 25.876 1.00 14.31 ? 105 ARG   B O    1 
ATOM   3984 C CB   . ARG   B 1 125 ? 32.251 -11.745 27.690 1.00 19.23 ? 105 ARG   B CB   1 
ATOM   3985 C CG   . ARG   B 1 125 ? 31.736 -10.347 27.955 1.00 25.00 ? 105 ARG   B CG   1 
ATOM   3986 C CD   . ARG   B 1 125 ? 32.674 -9.276  27.415 1.00 30.96 ? 105 ARG   B CD   1 
ATOM   3987 N NE   . ARG   B 1 125 ? 32.075 -7.947  27.529 1.00 49.73 ? 105 ARG   B NE   1 
ATOM   3988 C CZ   . ARG   B 1 125 ? 32.756 -6.809  27.502 1.00 43.21 ? 105 ARG   B CZ   1 
ATOM   3989 N NH1  . ARG   B 1 125 ? 34.078 -6.794  27.411 1.00 37.06 ? 105 ARG   B NH1  1 
ATOM   3990 N NH2  . ARG   B 1 125 ? 32.096 -5.656  27.575 1.00 49.91 ? 105 ARG   B NH2  1 
ATOM   3991 H H    . ARG   B 1 125 ? 30.223 -12.213 26.200 1.00 15.38 ? 105 ARG   B H    1 
ATOM   3992 H HA   . ARG   B 1 125 ? 32.826 -11.592 25.734 1.00 15.88 ? 105 ARG   B HA   1 
ATOM   3993 H HB2  . ARG   B 1 125 ? 31.713 -12.365 28.207 1.00 23.08 ? 105 ARG   B HB2  1 
ATOM   3994 H HB3  . ARG   B 1 125 ? 33.175 -11.784 27.982 1.00 23.08 ? 105 ARG   B HB3  1 
ATOM   3995 H HG2  . ARG   B 1 125 ? 30.873 -10.238 27.524 1.00 30.01 ? 105 ARG   B HG2  1 
ATOM   3996 H HG3  . ARG   B 1 125 ? 31.647 -10.216 28.912 1.00 30.01 ? 105 ARG   B HG3  1 
ATOM   3997 H HD2  . ARG   B 1 125 ? 33.501 -9.285  27.924 1.00 37.17 ? 105 ARG   B HD2  1 
ATOM   3998 H HD3  . ARG   B 1 125 ? 32.859 -9.451  26.479 1.00 37.17 ? 105 ARG   B HD3  1 
ATOM   3999 H HE   . ARG   B 1 125 ? 31.221 -7.900  27.619 1.00 59.69 ? 105 ARG   B HE   1 
ATOM   4000 H HH11 . ARG   B 1 125 ? 34.514 -7.534  27.367 1.00 44.48 ? 105 ARG   B HH11 1 
ATOM   4001 H HH12 . ARG   B 1 125 ? 34.500 -6.045  27.395 1.00 44.48 ? 105 ARG   B HH12 1 
ATOM   4002 H HH21 . ARG   B 1 125 ? 31.239 -5.655  27.638 1.00 59.90 ? 105 ARG   B HH21 1 
ATOM   4003 H HH22 . ARG   B 1 125 ? 32.527 -4.912  27.559 1.00 59.90 ? 105 ARG   B HH22 1 
ATOM   4004 N N    . GLY   B 1 126 ? 33.820 -13.881 26.068 1.00 13.74 ? 106 GLY   B N    1 
ATOM   4005 C CA   . GLY   B 1 126 ? 34.280 -15.251 26.106 1.00 13.77 ? 106 GLY   B CA   1 
ATOM   4006 C C    . GLY   B 1 126 ? 35.494 -15.335 26.991 1.00 11.84 ? 106 GLY   B C    1 
ATOM   4007 O O    . GLY   B 1 126 ? 36.296 -14.403 27.034 1.00 13.61 ? 106 GLY   B O    1 
ATOM   4008 H H    . GLY   B 1 126 ? 34.447 -13.292 26.067 1.00 16.50 ? 106 GLY   B H    1 
ATOM   4009 H HA2  . GLY   B 1 126 ? 33.585 -15.828 26.460 1.00 16.54 ? 106 GLY   B HA2  1 
ATOM   4010 H HA3  . GLY   B 1 126 ? 34.514 -15.550 25.213 1.00 16.54 ? 106 GLY   B HA3  1 
ATOM   4011 N N    . GLU   B 1 127 ? 35.640 -16.426 27.730 1.00 12.40 ? 107 GLU   B N    1 
ATOM   4012 C CA   . GLU   B 1 127 ? 36.827 -16.564 28.545 1.00 12.20 ? 107 GLU   B CA   1 
ATOM   4013 C C    . GLU   B 1 127 ? 37.129 -18.025 28.844 1.00 12.30 ? 107 GLU   B C    1 
ATOM   4014 O O    . GLU   B 1 127 ? 36.254 -18.902 28.820 1.00 13.86 ? 107 GLU   B O    1 
ATOM   4015 C CB   . GLU   B 1 127 ? 36.697 -15.797 29.856 1.00 16.93 ? 107 GLU   B CB   1 
ATOM   4016 C CG   . GLU   B 1 127 ? 35.727 -16.393 30.841 1.00 15.36 ? 107 GLU   B CG   1 
ATOM   4017 C CD   . GLU   B 1 127 ? 35.802 -15.668 32.166 1.00 22.51 ? 107 GLU   B CD   1 
ATOM   4018 O OE1  . GLU   B 1 127 ? 35.686 -14.424 32.144 1.00 19.62 ? 107 GLU   B OE1  1 
ATOM   4019 O OE2  . GLU   B 1 127 ? 36.009 -16.333 33.197 1.00 19.84 ? 107 GLU   B OE2  1 
ATOM   4020 H H    . GLU   B 1 127 ? 35.081 -17.078 27.773 1.00 14.89 ? 107 GLU   B H    1 
ATOM   4021 H HA   . GLU   B 1 127 ? 37.571 -16.215 28.030 1.00 14.65 ? 107 GLU   B HA   1 
ATOM   4022 H HB2  . GLU   B 1 127 ? 37.567 -15.769 30.283 1.00 20.33 ? 107 GLU   B HB2  1 
ATOM   4023 H HB3  . GLU   B 1 127 ? 36.396 -14.897 29.657 1.00 20.33 ? 107 GLU   B HB3  1 
ATOM   4024 H HG2  . GLU   B 1 127 ? 34.824 -16.314 30.496 1.00 18.45 ? 107 GLU   B HG2  1 
ATOM   4025 H HG3  . GLU   B 1 127 ? 35.945 -17.327 30.987 1.00 18.45 ? 107 GLU   B HG3  1 
ATOM   4026 N N    . GLY   B 1 128 ? 38.389 -18.251 29.167 1.00 14.44 ? 108 GLY   B N    1 
ATOM   4027 C CA   . GLY   B 1 128 ? 38.821 -19.547 29.633 1.00 14.48 ? 108 GLY   B CA   1 
ATOM   4028 C C    . GLY   B 1 128 ? 40.324 -19.633 29.551 1.00 12.39 ? 108 GLY   B C    1 
ATOM   4029 O O    . GLY   B 1 128 ? 41.007 -18.692 29.145 1.00 14.83 ? 108 GLY   B O    1 
ATOM   4030 H H    . GLY   B 1 128 ? 39.016 -17.664 29.125 1.00 17.35 ? 108 GLY   B H    1 
ATOM   4031 H HA2  . GLY   B 1 128 ? 38.544 -19.680 30.553 1.00 17.39 ? 108 GLY   B HA2  1 
ATOM   4032 H HA3  . GLY   B 1 128 ? 38.432 -20.245 29.082 1.00 17.39 ? 108 GLY   B HA3  1 
ATOM   4033 N N    . ALA   B 1 129 ? 40.826 -20.792 29.957 1.00 14.74 ? 109 ALA   B N    1 
ATOM   4034 C CA   . ALA   B 1 129 ? 42.245 -21.051 29.812 1.00 15.84 ? 109 ALA   B CA   1 
ATOM   4035 C C    . ALA   B 1 129 ? 42.624 -21.059 28.337 1.00 14.25 ? 109 ALA   B C    1 
ATOM   4036 O O    . ALA   B 1 129 ? 41.842 -21.462 27.473 1.00 15.20 ? 109 ALA   B O    1 
ATOM   4037 C CB   . ALA   B 1 129 ? 42.609 -22.380 30.459 1.00 19.30 ? 109 ALA   B CB   1 
ATOM   4038 H H    . ALA   B 1 129 ? 40.373 -21.431 30.313 1.00 17.71 ? 109 ALA   B H    1 
ATOM   4039 H HA   . ALA   B 1 129 ? 42.755 -20.355 30.256 1.00 19.02 ? 109 ALA   B HA   1 
ATOM   4040 H HB1  . ALA   B 1 129 ? 43.560 -22.534 30.351 1.00 23.18 ? 109 ALA   B HB1  1 
ATOM   4041 H HB2  . ALA   B 1 129 ? 42.384 -22.344 31.402 1.00 23.18 ? 109 ALA   B HB2  1 
ATOM   4042 H HB3  . ALA   B 1 129 ? 42.108 -23.089 30.026 1.00 23.18 ? 109 ALA   B HB3  1 
ATOM   4043 N N    . ILE   B 1 130 ? 43.839 -20.606 28.055 1.00 15.42 ? 110 ILE   B N    1 
ATOM   4044 C CA   . ILE   B 1 130 ? 44.403 -20.686 26.713 1.00 14.87 ? 110 ILE   B CA   1 
ATOM   4045 C C    . ILE   B 1 130 ? 45.668 -21.539 26.801 1.00 15.44 ? 110 ILE   B C    1 
ATOM   4046 O O    . ILE   B 1 130 ? 46.560 -21.272 27.618 1.00 15.86 ? 110 ILE   B O    1 
ATOM   4047 C CB   . ILE   B 1 130 ? 44.647 -19.289 26.108 1.00 14.58 ? 110 ILE   B CB   1 
ATOM   4048 C CG1  . ILE   B 1 130 ? 45.101 -19.430 24.651 1.00 17.56 ? 110 ILE   B CG1  1 
ATOM   4049 C CG2  . ILE   B 1 130 ? 45.592 -18.451 26.956 1.00 15.97 ? 110 ILE   B CG2  1 
ATOM   4050 C CD1  . ILE   B 1 130 ? 44.991 -18.163 23.855 1.00 16.52 ? 110 ILE   B CD1  1 
ATOM   4051 H H    . ILE   B 1 130 ? 44.363 -20.243 28.632 1.00 18.52 ? 110 ILE   B H    1 
ATOM   4052 H HA   . ILE   B 1 130 ? 43.794 -21.142 26.112 1.00 17.86 ? 110 ILE   B HA   1 
ATOM   4053 H HB   . ILE   B 1 130 ? 43.810 -18.800 26.109 1.00 17.51 ? 110 ILE   B HB   1 
ATOM   4054 H HG12 . ILE   B 1 130 ? 46.031 -19.706 24.640 1.00 21.09 ? 110 ILE   B HG12 1 
ATOM   4055 H HG13 . ILE   B 1 130 ? 44.551 -20.100 24.217 1.00 21.09 ? 110 ILE   B HG13 1 
ATOM   4056 H HG21 . ILE   B 1 130 ? 45.547 -17.528 26.661 1.00 19.18 ? 110 ILE   B HG21 1 
ATOM   4057 H HG22 . ILE   B 1 130 ? 45.323 -18.515 27.885 1.00 19.18 ? 110 ILE   B HG22 1 
ATOM   4058 H HG23 . ILE   B 1 130 ? 46.495 -18.789 26.849 1.00 19.18 ? 110 ILE   B HG23 1 
ATOM   4059 H HD11 . ILE   B 1 130 ? 44.994 -18.382 22.910 1.00 19.84 ? 110 ILE   B HD11 1 
ATOM   4060 H HD12 . ILE   B 1 130 ? 44.163 -17.714 24.088 1.00 19.84 ? 110 ILE   B HD12 1 
ATOM   4061 H HD13 . ILE   B 1 130 ? 45.747 -17.592 24.065 1.00 19.84 ? 110 ILE   B HD13 1 
ATOM   4062 N N    . VAL   B 1 131 ? 45.691 -22.611 26.019 1.00 16.55 ? 111 VAL   B N    1 
ATOM   4063 C CA   . VAL   B 1 131 ? 46.760 -23.606 26.034 1.00 17.91 ? 111 VAL   B CA   1 
ATOM   4064 C C    . VAL   B 1 131 ? 47.249 -23.696 24.594 1.00 15.61 ? 111 VAL   B C    1 
ATOM   4065 O O    . VAL   B 1 131 ? 46.976 -24.672 23.883 1.00 19.80 ? 111 VAL   B O    1 
ATOM   4066 C CB   . VAL   B 1 131 ? 46.277 -24.959 26.568 1.00 19.35 ? 111 VAL   B CB   1 
ATOM   4067 C CG1  . VAL   B 1 131 ? 47.470 -25.874 26.797 1.00 20.03 ? 111 VAL   B CG1  1 
ATOM   4068 C CG2  . VAL   B 1 131 ? 45.496 -24.749 27.851 1.00 20.98 ? 111 VAL   B CG2  1 
ATOM   4069 H H    . VAL   B 1 131 ? 45.075 -22.794 25.447 1.00 19.88 ? 111 VAL   B H    1 
ATOM   4070 H HA   . VAL   B 1 131 ? 47.486 -23.338 26.619 1.00 21.51 ? 111 VAL   B HA   1 
ATOM   4071 H HB   . VAL   B 1 131 ? 45.690 -25.384 25.923 1.00 23.23 ? 111 VAL   B HB   1 
ATOM   4072 H HG11 . VAL   B 1 131 ? 47.150 -26.755 27.045 1.00 24.05 ? 111 VAL   B HG11 1 
ATOM   4073 H HG12 . VAL   B 1 131 ? 47.988 -25.929 25.978 1.00 24.05 ? 111 VAL   B HG12 1 
ATOM   4074 H HG13 . VAL   B 1 131 ? 48.017 -25.508 27.509 1.00 24.05 ? 111 VAL   B HG13 1 
ATOM   4075 H HG21 . VAL   B 1 131 ? 45.288 -25.613 28.239 1.00 25.19 ? 111 VAL   B HG21 1 
ATOM   4076 H HG22 . VAL   B 1 131 ? 46.036 -24.231 28.468 1.00 25.19 ? 111 VAL   B HG22 1 
ATOM   4077 H HG23 . VAL   B 1 131 ? 44.676 -24.272 27.647 1.00 25.19 ? 111 VAL   B HG23 1 
ATOM   4078 N N    A PHE   B 1 132 ? 47.970 -22.677 24.145 0.52 17.31 ? 112 PHE   B N    1 
ATOM   4079 N N    B PHE   B 1 132 ? 47.937 -22.652 24.160 0.48 17.36 ? 112 PHE   B N    1 
ATOM   4080 C CA   A PHE   B 1 132 ? 48.405 -22.483 22.760 0.52 18.79 ? 112 PHE   B CA   1 
ATOM   4081 C CA   B PHE   B 1 132 ? 48.416 -22.596 22.794 0.48 18.70 ? 112 PHE   B CA   1 
ATOM   4082 C C    A PHE   B 1 132 ? 49.797 -23.083 22.561 0.52 16.64 ? 112 PHE   B C    1 
ATOM   4083 C C    B PHE   B 1 132 ? 49.766 -23.276 22.683 0.48 16.40 ? 112 PHE   B C    1 
ATOM   4084 O O    A PHE   B 1 132 ? 50.715 -22.754 23.319 0.52 18.47 ? 112 PHE   B O    1 
ATOM   4085 O O    B PHE   B 1 132 ? 50.595 -23.165 23.591 0.48 18.24 ? 112 PHE   B O    1 
ATOM   4086 C CB   A PHE   B 1 132 ? 48.419 -20.988 22.451 0.52 20.14 ? 112 PHE   B CB   1 
ATOM   4087 C CB   B PHE   B 1 132 ? 48.548 -21.160 22.323 0.48 19.22 ? 112 PHE   B CB   1 
ATOM   4088 C CG   A PHE   B 1 132 ? 47.945 -20.613 21.073 0.52 17.48 ? 112 PHE   B CG   1 
ATOM   4089 C CG   B PHE   B 1 132 ? 47.387 -20.694 21.532 0.48 15.51 ? 112 PHE   B CG   1 
ATOM   4090 C CD1  A PHE   B 1 132 ? 46.600 -20.371 20.817 0.52 24.84 ? 112 PHE   B CD1  1 
ATOM   4091 C CD1  B PHE   B 1 132 ? 46.104 -21.092 21.864 0.48 18.52 ? 112 PHE   B CD1  1 
ATOM   4092 C CD2  A PHE   B 1 132 ? 48.855 -20.439 20.048 0.52 21.39 ? 112 PHE   B CD2  1 
ATOM   4093 C CD2  B PHE   B 1 132 ? 47.571 -19.856 20.450 0.48 19.40 ? 112 PHE   B CD2  1 
ATOM   4094 C CE1  A PHE   B 1 132 ? 46.176 -19.999 19.551 0.52 22.12 ? 112 PHE   B CE1  1 
ATOM   4095 C CE1  B PHE   B 1 132 ? 45.029 -20.664 21.129 0.48 17.62 ? 112 PHE   B CE1  1 
ATOM   4096 C CE2  A PHE   B 1 132 ? 48.439 -20.061 18.788 0.52 21.50 ? 112 PHE   B CE2  1 
ATOM   4097 C CE2  B PHE   B 1 132 ? 46.501 -19.420 19.714 0.48 19.61 ? 112 PHE   B CE2  1 
ATOM   4098 C CZ   A PHE   B 1 132 ? 47.096 -19.841 18.540 0.52 22.40 ? 112 PHE   B CZ   1 
ATOM   4099 C CZ   B PHE   B 1 132 ? 45.224 -19.826 20.054 0.48 27.05 ? 112 PHE   B CZ   1 
ATOM   4100 H H    A PHE   B 1 132 ? 48.240 -22.039 24.653 0.52 20.78 ? 112 PHE   B H    1 
ATOM   4101 H H    B PHE   B 1 132 ? 48.138 -21.965 24.636 0.48 20.84 ? 112 PHE   B H    1 
ATOM   4102 H HA   A PHE   B 1 132 ? 47.806 -22.929 22.140 0.52 22.57 ? 112 PHE   B HA   1 
ATOM   4103 H HA   B PHE   B 1 132 ? 47.786 -23.051 22.214 0.48 22.46 ? 112 PHE   B HA   1 
ATOM   4104 H HB2  A PHE   B 1 132 ? 47.843 -20.538 23.088 0.52 24.18 ? 112 PHE   B HB2  1 
ATOM   4105 H HB2  B PHE   B 1 132 ? 48.631 -20.582 23.098 0.48 23.08 ? 112 PHE   B HB2  1 
ATOM   4106 H HB3  A PHE   B 1 132 ? 49.329 -20.665 22.542 0.52 24.18 ? 112 PHE   B HB3  1 
ATOM   4107 H HB3  B PHE   B 1 132 ? 49.338 -21.084 21.767 0.48 23.08 ? 112 PHE   B HB3  1 
ATOM   4108 H HD1  A PHE   B 1 132 ? 45.978 -20.459 21.503 0.52 29.83 ? 112 PHE   B HD1  1 
ATOM   4109 H HD1  B PHE   B 1 132 ? 45.970 -21.654 22.592 0.48 22.24 ? 112 PHE   B HD1  1 
ATOM   4110 H HD2  A PHE   B 1 132 ? 49.760 -20.579 20.209 0.52 25.68 ? 112 PHE   B HD2  1 
ATOM   4111 H HD2  B PHE   B 1 132 ? 48.430 -19.585 20.218 0.48 23.29 ? 112 PHE   B HD2  1 
ATOM   4112 H HE1  A PHE   B 1 132 ? 45.272 -19.856 19.385 0.52 26.56 ? 112 PHE   B HE1  1 
ATOM   4113 H HE1  B PHE   B 1 132 ? 44.170 -20.939 21.356 0.48 21.16 ? 112 PHE   B HE1  1 
ATOM   4114 H HE2  A PHE   B 1 132 ? 49.061 -19.954 18.106 0.52 25.82 ? 112 PHE   B HE2  1 
ATOM   4115 H HE2  B PHE   B 1 132 ? 46.632 -18.853 18.989 0.48 23.55 ? 112 PHE   B HE2  1 
ATOM   4116 H HZ   A PHE   B 1 132 ? 46.816 -19.586 17.690 0.52 26.89 ? 112 PHE   B HZ   1 
ATOM   4117 H HZ   B PHE   B 1 132 ? 44.495 -19.534 19.555 0.48 32.47 ? 112 PHE   B HZ   1 
ATOM   4118 N N    . PRO   B 1 133 ? 49.986 -23.957 21.565 1.00 19.87 ? 113 PRO   B N    1 
ATOM   4119 C CA   . PRO   B 1 133 ? 51.302 -24.563 21.340 1.00 25.94 ? 113 PRO   B CA   1 
ATOM   4120 C C    . PRO   B 1 133 ? 52.390 -23.503 21.296 1.00 20.56 ? 113 PRO   B C    1 
ATOM   4121 O O    . PRO   B 1 133 ? 52.300 -22.535 20.545 1.00 23.84 ? 113 PRO   B O    1 
ATOM   4122 C CB   . PRO   B 1 133 ? 51.141 -25.262 19.983 1.00 22.82 ? 113 PRO   B CB   1 
ATOM   4123 C CG   . PRO   B 1 133 ? 49.681 -25.427 19.777 1.00 30.33 ? 113 PRO   B CG   1 
ATOM   4124 C CD   . PRO   B 1 133 ? 49.021 -24.292 20.497 1.00 22.80 ? 113 PRO   B CD   1 
ATOM   4125 H HA   . PRO   B 1 133 ? 51.504 -25.219 22.027 1.00 31.15 ? 113 PRO   B HA   1 
ATOM   4126 H HB2  . PRO   B 1 133 ? 51.526 -24.709 19.285 1.00 27.39 ? 113 PRO   B HB2  1 
ATOM   4127 H HB3  . PRO   B 1 133 ? 51.585 -26.124 20.006 1.00 27.39 ? 113 PRO   B HB3  1 
ATOM   4128 H HG2  . PRO   B 1 133 ? 49.481 -25.393 18.829 1.00 36.40 ? 113 PRO   B HG2  1 
ATOM   4129 H HG3  . PRO   B 1 133 ? 49.395 -26.278 20.146 1.00 36.40 ? 113 PRO   B HG3  1 
ATOM   4130 H HD2  . PRO   B 1 133 ? 48.889 -23.537 19.902 1.00 27.37 ? 113 PRO   B HD2  1 
ATOM   4131 H HD3  . PRO   B 1 133 ? 48.172 -24.569 20.874 1.00 27.37 ? 113 PRO   B HD3  1 
ATOM   4132 N N    . GLY   B 1 134 ? 53.413 -23.691 22.108 1.00 24.96 ? 114 GLY   B N    1 
ATOM   4133 C CA   . GLY   B 1 134 ? 54.563 -22.817 22.095 1.00 25.22 ? 114 GLY   B CA   1 
ATOM   4134 C C    . GLY   B 1 134 ? 54.457 -21.598 22.976 1.00 30.49 ? 114 GLY   B C    1 
ATOM   4135 O O    . GLY   B 1 134 ? 55.371 -20.762 22.969 1.00 27.51 ? 114 GLY   B O    1 
ATOM   4136 H H    . GLY   B 1 134 ? 53.464 -24.328 22.684 1.00 29.96 ? 114 GLY   B H    1 
ATOM   4137 H HA2  . GLY   B 1 134 ? 55.339 -23.323 22.385 1.00 30.28 ? 114 GLY   B HA2  1 
ATOM   4138 H HA3  . GLY   B 1 134 ? 54.708 -22.512 21.186 1.00 30.28 ? 114 GLY   B HA3  1 
ATOM   4139 N N    . TYR   B 1 135 ? 53.377 -21.469 23.733 1.00 22.05 ? 115 TYR   B N    1 
ATOM   4140 C CA   . TYR   B 1 135 ? 53.185 -20.353 24.639 1.00 21.69 ? 115 TYR   B CA   1 
ATOM   4141 C C    . TYR   B 1 135 ? 52.833 -20.879 26.019 1.00 19.90 ? 115 TYR   B C    1 
ATOM   4142 O O    . TYR   B 1 135 ? 52.268 -21.973 26.148 1.00 21.63 ? 115 TYR   B O    1 
ATOM   4143 C CB   . TYR   B 1 135 ? 52.074 -19.430 24.130 1.00 19.88 ? 115 TYR   B CB   1 
ATOM   4144 C CG   . TYR   B 1 135 ? 52.462 -18.731 22.867 1.00 17.67 ? 115 TYR   B CG   1 
ATOM   4145 C CD1  . TYR   B 1 135 ? 53.108 -17.507 22.887 1.00 17.47 ? 115 TYR   B CD1  1 
ATOM   4146 C CD2  . TYR   B 1 135 ? 52.196 -19.310 21.622 1.00 18.97 ? 115 TYR   B CD2  1 
ATOM   4147 C CE1  . TYR   B 1 135 ? 53.465 -16.873 21.722 1.00 17.86 ? 115 TYR   B CE1  1 
ATOM   4148 C CE2  . TYR   B 1 135 ? 52.549 -18.679 20.463 1.00 20.17 ? 115 TYR   B CE2  1 
ATOM   4149 C CZ   . TYR   B 1 135 ? 53.184 -17.453 20.515 1.00 17.99 ? 115 TYR   B CZ   1 
ATOM   4150 O OH   . TYR   B 1 135 ? 53.535 -16.833 19.346 1.00 21.65 ? 115 TYR   B OH   1 
ATOM   4151 H H    . TYR   B 1 135 ? 52.726 -22.030 23.738 1.00 26.47 ? 115 TYR   B H    1 
ATOM   4152 H HA   . TYR   B 1 135 ? 53.999 -19.831 24.714 1.00 26.04 ? 115 TYR   B HA   1 
ATOM   4153 H HB2  . TYR   B 1 135 ? 51.279 -19.957 23.953 1.00 23.86 ? 115 TYR   B HB2  1 
ATOM   4154 H HB3  . TYR   B 1 135 ? 51.885 -18.758 24.803 1.00 23.86 ? 115 TYR   B HB3  1 
ATOM   4155 H HD1  . TYR   B 1 135 ? 53.304 -17.106 23.703 1.00 20.98 ? 115 TYR   B HD1  1 
ATOM   4156 H HD2  . TYR   B 1 135 ? 51.772 -20.137 21.583 1.00 22.77 ? 115 TYR   B HD2  1 
ATOM   4157 H HE1  . TYR   B 1 135 ? 53.898 -16.051 21.753 1.00 21.44 ? 115 TYR   B HE1  1 
ATOM   4158 H HE2  . TYR   B 1 135 ? 52.362 -19.073 19.642 1.00 24.22 ? 115 TYR   B HE2  1 
ATOM   4159 H HH   . TYR   B 1 135 ? 53.952 -16.123 19.512 1.00 26.00 ? 115 TYR   B HH   1 
ATOM   4160 N N    . PRO   B 1 136 ? 53.174 -20.132 27.071 1.00 20.62 ? 116 PRO   B N    1 
ATOM   4161 C CA   . PRO   B 1 136 ? 52.797 -20.564 28.417 1.00 22.70 ? 116 PRO   B CA   1 
ATOM   4162 C C    . PRO   B 1 136 ? 51.287 -20.630 28.544 1.00 19.91 ? 116 PRO   B C    1 
ATOM   4163 O O    . PRO   B 1 136 ? 50.561 -19.818 27.968 1.00 18.37 ? 116 PRO   B O    1 
ATOM   4164 C CB   . PRO   B 1 136 ? 53.392 -19.480 29.326 1.00 24.32 ? 116 PRO   B CB   1 
ATOM   4165 C CG   . PRO   B 1 136 ? 54.361 -18.709 28.470 1.00 26.51 ? 116 PRO   B CG   1 
ATOM   4166 C CD   . PRO   B 1 136 ? 53.825 -18.813 27.072 1.00 23.55 ? 116 PRO   B CD   1 
ATOM   4167 H HA   . PRO   B 1 136 ? 53.194 -21.421 28.637 1.00 27.25 ? 116 PRO   B HA   1 
ATOM   4168 H HB2  . PRO   B 1 136 ? 52.684 -18.902 29.650 1.00 29.20 ? 116 PRO   B HB2  1 
ATOM   4169 H HB3  . PRO   B 1 136 ? 53.849 -19.897 30.073 1.00 29.20 ? 116 PRO   B HB3  1 
ATOM   4170 H HG2  . PRO   B 1 136 ? 54.392 -17.784 28.761 1.00 31.83 ? 116 PRO   B HG2  1 
ATOM   4171 H HG3  . PRO   B 1 136 ? 55.243 -19.107 28.532 1.00 31.83 ? 116 PRO   B HG3  1 
ATOM   4172 H HD2  . PRO   B 1 136 ? 53.183 -18.108 26.894 1.00 28.27 ? 116 PRO   B HD2  1 
ATOM   4173 H HD3  . PRO   B 1 136 ? 54.544 -18.779 26.422 1.00 28.27 ? 116 PRO   B HD3  1 
ATOM   4174 N N    . ARG   B 1 137 ? 50.819 -21.611 29.300 1.00 21.20 ? 117 ARG   B N    1 
ATOM   4175 C CA   . ARG   B 1 137 ? 49.406 -21.677 29.626 1.00 19.95 ? 117 ARG   B CA   1 
ATOM   4176 C C    . ARG   B 1 137 ? 48.986 -20.361 30.260 1.00 23.44 ? 117 ARG   B C    1 
ATOM   4177 O O    . ARG   B 1 137 ? 49.705 -19.785 31.084 1.00 24.23 ? 117 ARG   B O    1 
ATOM   4178 C CB   . ARG   B 1 137 ? 49.116 -22.841 30.570 1.00 26.27 ? 117 ARG   B CB   1 
ATOM   4179 C CG   . ARG   B 1 137 ? 47.640 -22.996 30.896 1.00 36.01 ? 117 ARG   B CG   1 
ATOM   4180 C CD   . ARG   B 1 137 ? 47.406 -24.077 31.942 1.00 43.64 ? 117 ARG   B CD   1 
ATOM   4181 N NE   . ARG   B 1 137 ? 45.995 -24.430 32.037 1.00 38.01 ? 117 ARG   B NE   1 
ATOM   4182 C CZ   . ARG   B 1 137 ? 45.451 -25.494 31.463 1.00 41.83 ? 117 ARG   B CZ   1 
ATOM   4183 N NH1  . ARG   B 1 137 ? 46.184 -26.365 30.788 1.00 51.45 ? 117 ARG   B NH1  1 
ATOM   4184 N NH2  . ARG   B 1 137 ? 44.138 -25.689 31.570 1.00 41.26 ? 117 ARG   B NH2  1 
ATOM   4185 H H    . ARG   B 1 137 ? 51.294 -22.245 29.634 1.00 25.45 ? 117 ARG   B H    1 
ATOM   4186 H HA   . ARG   B 1 137 ? 48.885 -21.829 28.822 1.00 23.96 ? 117 ARG   B HA   1 
ATOM   4187 H HB2  . ARG   B 1 137 ? 49.418 -23.664 30.155 1.00 31.54 ? 117 ARG   B HB2  1 
ATOM   4188 H HB3  . ARG   B 1 137 ? 49.592 -22.696 31.402 1.00 31.54 ? 117 ARG   B HB3  1 
ATOM   4189 H HG2  . ARG   B 1 137 ? 47.298 -22.157 31.243 1.00 43.23 ? 117 ARG   B HG2  1 
ATOM   4190 H HG3  . ARG   B 1 137 ? 47.157 -23.243 30.091 1.00 43.23 ? 117 ARG   B HG3  1 
ATOM   4191 H HD2  . ARG   B 1 137 ? 47.905 -24.872 31.699 1.00 52.38 ? 117 ARG   B HD2  1 
ATOM   4192 H HD3  . ARG   B 1 137 ? 47.699 -23.753 32.809 1.00 52.38 ? 117 ARG   B HD3  1 
ATOM   4193 H HE   . ARG   B 1 137 ? 45.481 -23.914 32.495 1.00 45.62 ? 117 ARG   B HE   1 
ATOM   4194 H HH11 . ARG   B 1 137 ? 47.032 -26.247 30.714 1.00 61.76 ? 117 ARG   B HH11 1 
ATOM   4195 H HH12 . ARG   B 1 137 ? 45.811 -27.049 30.423 1.00 61.76 ? 117 ARG   B HH12 1 
ATOM   4196 H HH21 . ARG   B 1 137 ? 43.654 -25.129 32.007 1.00 49.52 ? 117 ARG   B HH21 1 
ATOM   4197 H HH22 . ARG   B 1 137 ? 43.774 -26.376 31.202 1.00 49.52 ? 117 ARG   B HH22 1 
ATOM   4198 N N    . GLY   B 1 138 ? 47.826 -19.873 29.853 1.00 21.39 ? 118 GLY   B N    1 
ATOM   4199 C CA   . GLY   B 1 138 ? 47.363 -18.597 30.339 1.00 23.34 ? 118 GLY   B CA   1 
ATOM   4200 C C    . GLY   B 1 138 ? 45.866 -18.583 30.525 1.00 16.68 ? 118 GLY   B C    1 
ATOM   4201 O O    . GLY   B 1 138 ? 45.197 -19.617 30.423 1.00 18.21 ? 118 GLY   B O    1 
ATOM   4202 H H    . GLY   B 1 138 ? 47.295 -20.263 29.300 1.00 25.68 ? 118 GLY   B H    1 
ATOM   4203 H HA2  . GLY   B 1 138 ? 47.783 -18.403 31.191 1.00 28.02 ? 118 GLY   B HA2  1 
ATOM   4204 H HA3  . GLY   B 1 138 ? 47.602 -17.903 29.704 1.00 28.02 ? 118 GLY   B HA3  1 
ATOM   4205 N N    . GLN   B 1 139 ? 45.340 -17.406 30.826 1.00 20.23 ? 119 GLN   B N    1 
ATOM   4206 C CA   . GLN   B 1 139 ? 43.912 -17.168 30.913 1.00 16.58 ? 119 GLN   B CA   1 
ATOM   4207 C C    . GLN   B 1 139 ? 43.579 -16.082 29.906 1.00 16.57 ? 119 GLN   B C    1 
ATOM   4208 O O    . GLN   B 1 139 ? 44.284 -15.072 29.810 1.00 22.38 ? 119 GLN   B O    1 
ATOM   4209 C CB   . GLN   B 1 139 ? 43.507 -16.743 32.320 1.00 19.98 ? 119 GLN   B CB   1 
ATOM   4210 C CG   . GLN   B 1 139 ? 43.837 -17.789 33.370 1.00 24.02 ? 119 GLN   B CG   1 
ATOM   4211 C CD   . GLN   B 1 139 ? 43.030 -19.065 33.213 1.00 26.78 ? 119 GLN   B CD   1 
ATOM   4212 O OE1  . GLN   B 1 139 ? 41.886 -19.041 32.751 1.00 26.38 ? 119 GLN   B OE1  1 
ATOM   4213 N NE2  . GLN   B 1 139 ? 43.623 -20.189 33.602 1.00 32.97 ? 119 GLN   B NE2  1 
ATOM   4214 H H    . GLN   B 1 139 ? 45.810 -16.704 30.990 1.00 24.29 ? 119 GLN   B H    1 
ATOM   4215 H HA   . GLN   B 1 139 ? 43.405 -17.970 30.707 1.00 19.91 ? 119 GLN   B HA   1 
ATOM   4216 H HB2  . GLN   B 1 139 ? 43.979 -15.927 32.550 1.00 23.99 ? 119 GLN   B HB2  1 
ATOM   4217 H HB3  . GLN   B 1 139 ? 42.550 -16.589 32.340 1.00 23.99 ? 119 GLN   B HB3  1 
ATOM   4218 H HG2  . GLN   B 1 139 ? 44.777 -18.020 33.301 1.00 28.84 ? 119 GLN   B HG2  1 
ATOM   4219 H HG3  . GLN   B 1 139 ? 43.650 -17.423 34.249 1.00 28.84 ? 119 GLN   B HG3  1 
ATOM   4220 H HE21 . GLN   B 1 139 ? 44.421 -20.165 33.921 1.00 39.58 ? 119 GLN   B HE21 1 
ATOM   4221 H HE22 . GLN   B 1 139 ? 43.209 -20.939 33.534 1.00 39.58 ? 119 GLN   B HE22 1 
ATOM   4222 N N    . TYR   B 1 140 ? 42.529 -16.315 29.133 1.00 14.39 ? 120 TYR   B N    1 
ATOM   4223 C CA   . TYR   B 1 140 ? 42.175 -15.457 28.015 1.00 15.08 ? 120 TYR   B CA   1 
ATOM   4224 C C    . TYR   B 1 140 ? 40.730 -15.027 28.198 1.00 13.22 ? 120 TYR   B C    1 
ATOM   4225 O O    . TYR   B 1 140 ? 39.860 -15.856 28.464 1.00 14.76 ? 120 TYR   B O    1 
ATOM   4226 C CB   . TYR   B 1 140 ? 42.399 -16.211 26.699 1.00 14.39 ? 120 TYR   B CB   1 
ATOM   4227 C CG   . TYR   B 1 140 ? 41.928 -15.524 25.449 1.00 12.37 ? 120 TYR   B CG   1 
ATOM   4228 C CD1  . TYR   B 1 140 ? 42.117 -14.168 25.261 1.00 16.49 ? 120 TYR   B CD1  1 
ATOM   4229 C CD2  . TYR   B 1 140 ? 41.310 -16.253 24.452 1.00 14.35 ? 120 TYR   B CD2  1 
ATOM   4230 C CE1  . TYR   B 1 140 ? 41.679 -13.549 24.106 1.00 15.98 ? 120 TYR   B CE1  1 
ATOM   4231 C CE2  . TYR   B 1 140 ? 40.873 -15.652 23.294 1.00 14.77 ? 120 TYR   B CE2  1 
ATOM   4232 C CZ   . TYR   B 1 140 ? 41.058 -14.297 23.133 1.00 15.97 ? 120 TYR   B CZ   1 
ATOM   4233 O OH   . TYR   B 1 140 ? 40.624 -13.683 21.979 1.00 16.44 ? 120 TYR   B OH   1 
ATOM   4234 H H    . TYR   B 1 140 ? 41.994 -16.980 29.239 1.00 17.28 ? 120 TYR   B H    1 
ATOM   4235 H HA   . TYR   B 1 140 ? 42.713 -14.650 27.987 1.00 18.10 ? 120 TYR   B HA   1 
ATOM   4236 H HB2  . TYR   B 1 140 ? 43.351 -16.365 26.598 1.00 17.28 ? 120 TYR   B HB2  1 
ATOM   4237 H HB3  . TYR   B 1 140 ? 41.930 -17.058 26.753 1.00 17.28 ? 120 TYR   B HB3  1 
ATOM   4238 H HD1  . TYR   B 1 140 ? 42.542 -13.667 25.919 1.00 19.81 ? 120 TYR   B HD1  1 
ATOM   4239 H HD2  . TYR   B 1 140 ? 41.187 -17.167 24.565 1.00 17.23 ? 120 TYR   B HD2  1 
ATOM   4240 H HE1  . TYR   B 1 140 ? 41.803 -12.635 23.987 1.00 19.19 ? 120 TYR   B HE1  1 
ATOM   4241 H HE2  . TYR   B 1 140 ? 40.457 -16.153 22.630 1.00 17.74 ? 120 TYR   B HE2  1 
ATOM   4242 H HH   . TYR   B 1 140 ? 40.048 -14.161 21.599 1.00 19.74 ? 120 TYR   B HH   1 
ATOM   4243 N N    . ARG   B 1 141 ? 40.495 -13.728 28.124 1.00 15.55 ? 121 ARG   B N    1 
ATOM   4244 C CA   . ARG   B 1 141 ? 39.158 -13.155 28.153 1.00 12.98 ? 121 ARG   B CA   1 
ATOM   4245 C C    . ARG   B 1 141 ? 39.086 -12.141 27.031 1.00 14.37 ? 121 ARG   B C    1 
ATOM   4246 O O    . ARG   B 1 141 ? 40.042 -11.398 26.790 1.00 17.04 ? 121 ARG   B O    1 
ATOM   4247 C CB   . ARG   B 1 141 ? 38.847 -12.480 29.496 1.00 17.27 ? 121 ARG   B CB   1 
ATOM   4248 C CG   . ARG   B 1 141 ? 37.463 -11.834 29.583 1.00 40.45 ? 121 ARG   B CG   1 
ATOM   4249 C CD   . ARG   B 1 141 ? 37.250 -11.201 30.961 1.00 42.76 ? 121 ARG   B CD   1 
ATOM   4250 N NE   . ARG   B 1 141 ? 37.612 -12.122 32.032 1.00 47.30 ? 121 ARG   B NE   1 
ATOM   4251 C CZ   . ARG   B 1 141 ? 38.777 -12.111 32.667 1.00 52.71 ? 121 ARG   B CZ   1 
ATOM   4252 N NH1  . ARG   B 1 141 ? 39.685 -11.178 32.430 1.00 65.77 ? 121 ARG   B NH1  1 
ATOM   4253 N NH2  . ARG   B 1 141 ? 39.043 -13.065 33.554 1.00 41.08 ? 121 ARG   B NH2  1 
ATOM   4254 H H    . ARG   B 1 141 ? 41.115 -13.136 28.054 1.00 18.67 ? 121 ARG   B H    1 
ATOM   4255 H HA   . ARG   B 1 141 ? 38.487 -13.844 28.026 1.00 15.59 ? 121 ARG   B HA   1 
ATOM   4256 H HB2  . ARG   B 1 141 ? 38.902 -13.148 30.197 1.00 20.73 ? 121 ARG   B HB2  1 
ATOM   4257 H HB3  . ARG   B 1 141 ? 39.504 -11.783 29.650 1.00 20.73 ? 121 ARG   B HB3  1 
ATOM   4258 H HG2  . ARG   B 1 141 ? 37.385 -11.141 28.909 1.00 48.55 ? 121 ARG   B HG2  1 
ATOM   4259 H HG3  . ARG   B 1 141 ? 36.781 -12.510 29.445 1.00 48.55 ? 121 ARG   B HG3  1 
ATOM   4260 H HD2  . ARG   B 1 141 ? 37.803 -10.408 31.039 1.00 51.32 ? 121 ARG   B HD2  1 
ATOM   4261 H HD3  . ARG   B 1 141 ? 36.315 -10.964 31.064 1.00 51.32 ? 121 ARG   B HD3  1 
ATOM   4262 H HE   . ARG   B 1 141 ? 37.033 -12.712 32.267 1.00 56.77 ? 121 ARG   B HE   1 
ATOM   4263 H HH11 . ARG   B 1 141 ? 40.434 -11.189 32.853 1.00 78.93 ? 121 ARG   B HH11 1 
ATOM   4264 H HH12 . ARG   B 1 141 ? 39.526 -10.560 31.853 1.00 78.93 ? 121 ARG   B HH12 1 
ATOM   4265 H HH21 . ARG   B 1 141 ? 38.462 -13.681 33.710 1.00 49.30 ? 121 ARG   B HH21 1 
ATOM   4266 H HH22 . ARG   B 1 141 ? 39.794 -13.067 33.971 1.00 49.30 ? 121 ARG   B HH22 1 
ATOM   4267 N N    . ASN   B 1 142 ? 37.970 -12.119 26.322 1.00 13.28 ? 122 ASN   B N    1 
ATOM   4268 C CA   . ASN   B 1 142 ? 37.846 -11.130 25.271 1.00 13.51 ? 122 ASN   B CA   1 
ATOM   4269 C C    . ASN   B 1 142 ? 36.393 -10.758 25.074 1.00 14.01 ? 122 ASN   B C    1 
ATOM   4270 O O    . ASN   B 1 142 ? 35.471 -11.383 25.608 1.00 14.46 ? 122 ASN   B O    1 
ATOM   4271 C CB   . ASN   B 1 142 ? 38.452 -11.625 23.943 1.00 14.87 ? 122 ASN   B CB   1 
ATOM   4272 C CG   . ASN   B 1 142 ? 39.141 -10.514 23.149 1.00 17.65 ? 122 ASN   B CG   1 
ATOM   4273 O OD1  . ASN   B 1 142 ? 38.842 -9.326  23.323 1.00 17.75 ? 122 ASN   B OD1  1 
ATOM   4274 N ND2  . ASN   B 1 142 ? 40.062 -10.897 22.282 1.00 15.99 ? 122 ASN   B ND2  1 
ATOM   4275 H H    . ASN   B 1 142 ? 37.299 -12.646 26.427 1.00 15.95 ? 122 ASN   B H    1 
ATOM   4276 H HA   . ASN   B 1 142 ? 38.323 -10.335 25.557 1.00 16.22 ? 122 ASN   B HA   1 
ATOM   4277 H HB2  . ASN   B 1 142 ? 39.112 -12.310 24.133 1.00 17.86 ? 122 ASN   B HB2  1 
ATOM   4278 H HB3  . ASN   B 1 142 ? 37.744 -11.992 23.390 1.00 17.86 ? 122 ASN   B HB3  1 
ATOM   4279 H HD21 . ASN   B 1 142 ? 40.480 -10.311 21.811 1.00 19.20 ? 122 ASN   B HD21 1 
ATOM   4280 H HD22 . ASN   B 1 142 ? 40.245 -11.732 22.190 1.00 19.20 ? 122 ASN   B HD22 1 
ATOM   4281 N N    A HIS   B 1 143 ? 36.212 -9.672  24.350 0.60 14.32 ? 123 HIS   B N    1 
ATOM   4282 N N    B HIS   B 1 143 ? 36.212 -9.743  24.230 0.40 14.39 ? 123 HIS   B N    1 
ATOM   4283 C CA   A HIS   B 1 143 ? 34.908 -9.236  23.898 0.60 14.11 ? 123 HIS   B CA   1 
ATOM   4284 C CA   B HIS   B 1 143 ? 34.923 -9.169  23.864 0.40 14.13 ? 123 HIS   B CA   1 
ATOM   4285 C C    A HIS   B 1 143 ? 34.761 -9.670  22.449 0.60 13.79 ? 123 HIS   B C    1 
ATOM   4286 C C    B HIS   B 1 143 ? 34.677 -9.494  22.397 0.40 16.08 ? 123 HIS   B C    1 
ATOM   4287 O O    A HIS   B 1 143 ? 35.696 -9.519  21.655 0.60 14.88 ? 123 HIS   B O    1 
ATOM   4288 O O    B HIS   B 1 143 ? 35.454 -9.078  21.531 0.40 16.62 ? 123 HIS   B O    1 
ATOM   4289 C CB   A HIS   B 1 143 ? 34.780 -7.726  24.054 0.60 13.89 ? 123 HIS   B CB   1 
ATOM   4290 C CB   B HIS   B 1 143 ? 34.953 -7.660  24.105 0.40 13.53 ? 123 HIS   B CB   1 
ATOM   4291 C CG   A HIS   B 1 143 ? 33.529 -7.172  23.468 0.60 14.39 ? 123 HIS   B CG   1 
ATOM   4292 C CG   B HIS   B 1 143 ? 33.643 -6.974  23.892 0.40 16.00 ? 123 HIS   B CG   1 
ATOM   4293 N ND1  A HIS   B 1 143 ? 33.437 -6.798  22.147 0.60 19.16 ? 123 HIS   B ND1  1 
ATOM   4294 N ND1  B HIS   B 1 143 ? 33.546 -5.604  23.780 0.40 19.98 ? 123 HIS   B ND1  1 
ATOM   4295 C CD2  A HIS   B 1 143 ? 32.319 -6.927  24.019 0.60 24.03 ? 123 HIS   B CD2  1 
ATOM   4296 C CD2  B HIS   B 1 143 ? 32.382 -7.454  23.785 0.40 17.81 ? 123 HIS   B CD2  1 
ATOM   4297 C CE1  A HIS   B 1 143 ? 32.220 -6.346  21.908 0.60 23.16 ? 123 HIS   B CE1  1 
ATOM   4298 C CE1  B HIS   B 1 143 ? 32.280 -5.270  23.608 0.40 17.28 ? 123 HIS   B CE1  1 
ATOM   4299 N NE2  A HIS   B 1 143 ? 31.525 -6.407  23.030 0.60 20.28 ? 123 HIS   B NE2  1 
ATOM   4300 N NE2  B HIS   B 1 143 ? 31.553 -6.373  23.605 0.40 15.87 ? 123 HIS   B NE2  1 
ATOM   4301 H H    A HIS   B 1 143 ? 36.851 -9.153  24.100 0.60 17.20 ? 123 HIS   B H    1 
ATOM   4302 H H    B HIS   B 1 143 ? 36.863 -9.347  23.833 0.40 17.28 ? 123 HIS   B H    1 
ATOM   4303 H HA   A HIS   B 1 143 ? 34.191 -9.637  24.413 0.60 16.95 ? 123 HIS   B HA   1 
ATOM   4304 H HA   B HIS   B 1 143 ? 34.200 -9.550  24.386 0.40 16.97 ? 123 HIS   B HA   1 
ATOM   4305 H HB2  A HIS   B 1 143 ? 34.787 -7.508  24.999 0.60 16.68 ? 123 HIS   B HB2  1 
ATOM   4306 H HB2  B HIS   B 1 143 ? 35.222 -7.499  25.022 0.40 16.25 ? 123 HIS   B HB2  1 
ATOM   4307 H HB3  A HIS   B 1 143 ? 35.530 -7.301  23.609 0.60 16.68 ? 123 HIS   B HB3  1 
ATOM   4308 H HB3  B HIS   B 1 143 ? 35.594 -7.263  23.495 0.40 16.25 ? 123 HIS   B HB3  1 
ATOM   4309 H HD2  A HIS   B 1 143 ? 32.073 -7.081  24.902 0.60 28.85 ? 123 HIS   B HD2  1 
ATOM   4310 H HD2  B HIS   B 1 143 ? 32.125 -8.347  23.825 0.40 21.39 ? 123 HIS   B HD2  1 
ATOM   4311 H HE1  A HIS   B 1 143 ? 31.905 -6.038  21.090 0.60 27.80 ? 123 HIS   B HE1  1 
ATOM   4312 H HE1  B HIS   B 1 143 ? 31.956 -4.405  23.505 0.40 20.75 ? 123 HIS   B HE1  1 
ATOM   4313 H HE2  A HIS   B 1 143 ? 30.706 -6.161  23.124 0.60 24.35 ? 123 HIS   B HE2  1 
ATOM   4314 H HE2  B HIS   B 1 143 ? 30.700 -6.409  23.508 0.40 19.06 ? 123 HIS   B HE2  1 
ATOM   4315 N N    . PHE   B 1 144 ? 33.611 -10.237 22.121 1.00 10.85 ? 124 PHE   B N    1 
ATOM   4316 C CA   . PHE   B 1 144 ? 33.389 -10.816 20.814 1.00 12.64 ? 124 PHE   B CA   1 
ATOM   4317 C C    . PHE   B 1 144 ? 32.134 -10.303 20.139 1.00 11.53 ? 124 PHE   B C    1 
ATOM   4318 O O    . PHE   B 1 144 ? 31.108 -10.085 20.777 1.00 12.97 ? 124 PHE   B O    1 
ATOM   4319 C CB   . PHE   B 1 144 ? 33.260 -12.336 20.916 1.00 13.85 ? 124 PHE   B CB   1 
ATOM   4320 C CG   . PHE   B 1 144 ? 34.505 -13.017 21.337 1.00 12.83 ? 124 PHE   B CG   1 
ATOM   4321 C CD1  . PHE   B 1 144 ? 34.828 -13.134 22.682 1.00 14.61 ? 124 PHE   B CD1  1 
ATOM   4322 C CD2  . PHE   B 1 144 ? 35.332 -13.579 20.398 1.00 16.23 ? 124 PHE   B CD2  1 
ATOM   4323 C CE1  . PHE   B 1 144 ? 35.968 -13.798 23.062 1.00 15.36 ? 124 PHE   B CE1  1 
ATOM   4324 C CE2  . PHE   B 1 144 ? 36.476 -14.238 20.780 1.00 15.28 ? 124 PHE   B CE2  1 
ATOM   4325 C CZ   . PHE   B 1 144 ? 36.802 -14.340 22.107 1.00 14.51 ? 124 PHE   B CZ   1 
ATOM   4326 H H    A PHE   B 1 144 ? 32.935 -10.298 22.649 0.60 13.03 ? 124 PHE   B H    1 
ATOM   4327 H H    B PHE   B 1 144 ? 32.993 -10.421 22.690 0.40 13.03 ? 124 PHE   B H    1 
ATOM   4328 H HA   . PHE   B 1 144 ? 34.140 -10.557 20.259 1.00 15.18 ? 124 PHE   B HA   1 
ATOM   4329 H HB2  . PHE   B 1 144 ? 32.573 -12.547 21.567 1.00 16.63 ? 124 PHE   B HB2  1 
ATOM   4330 H HB3  . PHE   B 1 144 ? 33.011 -12.686 20.046 1.00 16.63 ? 124 PHE   B HB3  1 
ATOM   4331 H HD1  . PHE   B 1 144 ? 34.271 -12.763 23.327 1.00 17.54 ? 124 PHE   B HD1  1 
ATOM   4332 H HD2  . PHE   B 1 144 ? 35.117 -13.513 19.495 1.00 19.49 ? 124 PHE   B HD2  1 
ATOM   4333 H HE1  . PHE   B 1 144 ? 36.179 -13.881 23.964 1.00 18.45 ? 124 PHE   B HE1  1 
ATOM   4334 H HE2  . PHE   B 1 144 ? 37.030 -14.616 20.136 1.00 18.35 ? 124 PHE   B HE2  1 
ATOM   4335 H HZ   . PHE   B 1 144 ? 37.583 -14.774 22.363 1.00 17.42 ? 124 PHE   B HZ   1 
ATOM   4336 N N    . LEU   B 1 145 ? 32.230 -10.152 18.821 1.00 13.00 ? 125 LEU   B N    1 
ATOM   4337 C CA   . LEU   B 1 145 ? 31.075 -10.046 17.950 1.00 11.40 ? 125 LEU   B CA   1 
ATOM   4338 C C    . LEU   B 1 145 ? 31.102 -11.260 17.038 1.00 12.32 ? 125 LEU   B C    1 
ATOM   4339 O O    . LEU   B 1 145 ? 32.149 -11.598 16.481 1.00 14.56 ? 125 LEU   B O    1 
ATOM   4340 C CB   . LEU   B 1 145 ? 31.085 -8.764  17.116 1.00 12.81 ? 125 LEU   B CB   1 
ATOM   4341 C CG   . LEU   B 1 145 ? 31.318 -7.522  17.972 1.00 19.81 ? 125 LEU   B CG   1 
ATOM   4342 C CD1  . LEU   B 1 145 ? 31.516 -6.282  17.121 1.00 21.94 ? 125 LEU   B CD1  1 
ATOM   4343 C CD2  . LEU   B 1 145 ? 30.172 -7.315  18.943 1.00 18.49 ? 125 LEU   B CD2  1 
ATOM   4344 H H    . LEU   B 1 145 ? 32.979 -10.107 18.400 1.00 15.61 ? 125 LEU   B H    1 
ATOM   4345 H HA   . LEU   B 1 145 ? 30.261 -10.029 18.477 1.00 13.69 ? 125 LEU   B HA   1 
ATOM   4346 H HB2  . LEU   B 1 145 ? 31.796 -8.818  16.459 1.00 15.38 ? 125 LEU   B HB2  1 
ATOM   4347 H HB3  . LEU   B 1 145 ? 30.228 -8.669  16.670 1.00 15.38 ? 125 LEU   B HB3  1 
ATOM   4348 H HG   . LEU   B 1 145 ? 32.133 -7.661  18.481 1.00 23.78 ? 125 LEU   B HG   1 
ATOM   4349 H HD11 . LEU   B 1 145 ? 31.531 -5.502  17.698 1.00 26.35 ? 125 LEU   B HD11 1 
ATOM   4350 H HD12 . LEU   B 1 145 ? 32.357 -6.357  16.644 1.00 26.35 ? 125 LEU   B HD12 1 
ATOM   4351 H HD13 . LEU   B 1 145 ? 30.783 -6.212  16.490 1.00 26.35 ? 125 LEU   B HD13 1 
ATOM   4352 H HD21 . LEU   B 1 145 ? 30.228 -6.419  19.310 1.00 22.20 ? 125 LEU   B HD21 1 
ATOM   4353 H HD22 . LEU   B 1 145 ? 29.333 -7.427  18.470 1.00 22.20 ? 125 LEU   B HD22 1 
ATOM   4354 H HD23 . LEU   B 1 145 ? 30.240 -7.969  19.656 1.00 22.20 ? 125 LEU   B HD23 1 
ATOM   4355 N N    . HIS   B 1 146 ? 29.981 -11.941 16.933 1.00 11.87 ? 126 HIS   B N    1 
ATOM   4356 C CA   . HIS   B 1 146 ? 29.838 -13.060 16.016 1.00 12.91 ? 126 HIS   B CA   1 
ATOM   4357 C C    . HIS   B 1 146 ? 28.835 -12.705 14.938 1.00 14.89 ? 126 HIS   B C    1 
ATOM   4358 O O    . HIS   B 1 146 ? 27.775 -12.141 15.227 1.00 13.80 ? 126 HIS   B O    1 
ATOM   4359 C CB   . HIS   B 1 146 ? 29.332 -14.326 16.694 1.00 12.92 ? 126 HIS   B CB   1 
ATOM   4360 C CG   . HIS   B 1 146 ? 30.293 -14.948 17.651 1.00 13.87 ? 126 HIS   B CG   1 
ATOM   4361 N ND1  . HIS   B 1 146 ? 31.058 -16.047 17.328 1.00 18.93 ? 126 HIS   B ND1  1 
ATOM   4362 C CD2  . HIS   B 1 146 ? 30.574 -14.658 18.941 1.00 17.19 ? 126 HIS   B CD2  1 
ATOM   4363 C CE1  . HIS   B 1 146 ? 31.788 -16.393 18.374 1.00 20.01 ? 126 HIS   B CE1  1 
ATOM   4364 N NE2  . HIS   B 1 146 ? 31.513 -15.565 19.366 1.00 16.19 ? 126 HIS   B NE2  1 
ATOM   4365 H H    . HIS   B 1 146 ? 29.273 -11.774 17.391 1.00 14.26 ? 126 HIS   B H    1 
ATOM   4366 H HA   . HIS   B 1 146 ? 30.712 -13.236 15.635 1.00 15.50 ? 126 HIS   B HA   1 
ATOM   4367 H HB2  . HIS   B 1 146 ? 28.526 -14.110 17.189 1.00 15.52 ? 126 HIS   B HB2  1 
ATOM   4368 H HB3  . HIS   B 1 146 ? 29.134 -14.985 16.009 1.00 15.52 ? 126 HIS   B HB3  1 
ATOM   4369 H HD2  . HIS   B 1 146 ? 30.201 -13.972 19.446 1.00 20.64 ? 126 HIS   B HD2  1 
ATOM   4370 H HE1  . HIS   B 1 146 ? 32.392 -17.099 18.406 1.00 24.02 ? 126 HIS   B HE1  1 
ATOM   4371 H HE2  . HIS   B 1 146 ? 31.864 -15.591 20.150 1.00 19.44 ? 126 HIS   B HE2  1 
ATOM   4372 N N    . SER   B 1 147 ? 29.145 -13.088 13.705 1.00 12.59 ? 127 SER   B N    1 
ATOM   4373 C CA   . SER   B 1 147 ? 28.221 -12.991 12.591 1.00 12.87 ? 127 SER   B CA   1 
ATOM   4374 C C    . SER   B 1 147 ? 27.807 -14.401 12.200 1.00 12.57 ? 127 SER   B C    1 
ATOM   4375 O O    . SER   B 1 147 ? 28.669 -15.269 12.018 1.00 14.04 ? 127 SER   B O    1 
ATOM   4376 C CB   . SER   B 1 147 ? 28.883 -12.262 11.425 1.00 12.01 ? 127 SER   B CB   1 
ATOM   4377 O OG   . SER   B 1 147 ? 28.066 -12.280 10.268 1.00 13.50 ? 127 SER   B OG   1 
ATOM   4378 H H    . SER   B 1 147 ? 29.909 -13.417 13.486 1.00 15.12 ? 127 SER   B H    1 
ATOM   4379 H HA   . SER   B 1 147 ? 27.423 -12.497 12.834 1.00 15.46 ? 127 SER   B HA   1 
ATOM   4380 H HB2  . SER   B 1 147 ? 29.042 -11.340 11.682 1.00 14.42 ? 127 SER   B HB2  1 
ATOM   4381 H HB3  . SER   B 1 147 ? 29.725 -12.699 11.221 1.00 14.42 ? 127 SER   B HB3  1 
ATOM   4382 H HG   . SER   B 1 147 ? 28.440 -12.721 9.659  1.00 16.21 ? 127 SER   B HG   1 
ATOM   4383 N N    . PHE   B 1 148 ? 26.493 -14.645 12.123 1.00 12.36 ? 128 PHE   B N    1 
ATOM   4384 C CA   . PHE   B 1 148 ? 25.968 -15.927 11.667 1.00 13.01 ? 128 PHE   B CA   1 
ATOM   4385 C C    . PHE   B 1 148 ? 25.091 -15.723 10.443 1.00 12.85 ? 128 PHE   B C    1 
ATOM   4386 O O    . PHE   B 1 148 ? 24.071 -15.038 10.526 1.00 14.80 ? 128 PHE   B O    1 
ATOM   4387 C CB   . PHE   B 1 148 ? 25.129 -16.614 12.749 1.00 13.50 ? 128 PHE   B CB   1 
ATOM   4388 C CG   . PHE   B 1 148 ? 25.880 -17.038 13.965 1.00 12.87 ? 128 PHE   B CG   1 
ATOM   4389 C CD1  . PHE   B 1 148 ? 26.031 -16.167 15.027 1.00 12.87 ? 128 PHE   B CD1  1 
ATOM   4390 C CD2  . PHE   B 1 148 ? 26.404 -18.311 14.068 1.00 15.97 ? 128 PHE   B CD2  1 
ATOM   4391 C CE1  . PHE   B 1 148 ? 26.701 -16.563 16.163 1.00 12.98 ? 128 PHE   B CE1  1 
ATOM   4392 C CE2  . PHE   B 1 148 ? 27.080 -18.706 15.203 1.00 15.62 ? 128 PHE   B CE2  1 
ATOM   4393 C CZ   . PHE   B 1 148 ? 27.229 -17.819 16.246 1.00 15.03 ? 128 PHE   B CZ   1 
ATOM   4394 H H    . PHE   B 1 148 ? 25.885 -14.074 12.333 1.00 14.85 ? 128 PHE   B H    1 
ATOM   4395 H HA   . PHE   B 1 148 ? 26.726 -16.485 11.434 1.00 15.62 ? 128 PHE   B HA   1 
ATOM   4396 H HB2  . PHE   B 1 148 ? 24.437 -15.998 13.036 1.00 16.21 ? 128 PHE   B HB2  1 
ATOM   4397 H HB3  . PHE   B 1 148 ? 24.727 -17.409 12.365 1.00 16.21 ? 128 PHE   B HB3  1 
ATOM   4398 H HD1  . PHE   B 1 148 ? 25.678 -15.308 14.974 1.00 15.45 ? 128 PHE   B HD1  1 
ATOM   4399 H HD2  . PHE   B 1 148 ? 26.299 -18.910 13.363 1.00 19.18 ? 128 PHE   B HD2  1 
ATOM   4400 H HE1  . PHE   B 1 148 ? 26.794 -15.973 16.875 1.00 15.59 ? 128 PHE   B HE1  1 
ATOM   4401 H HE2  . PHE   B 1 148 ? 27.432 -19.564 15.264 1.00 18.76 ? 128 PHE   B HE2  1 
ATOM   4402 H HZ   . PHE   B 1 148 ? 27.691 -18.078 17.011 1.00 18.05 ? 128 PHE   B HZ   1 
ATOM   4403 N N    . ARG   B 1 149 ? 25.462 -16.340 9.330  1.00 13.90 ? 129 ARG   B N    1 
ATOM   4404 C CA   . ARG   B 1 149 ? 24.627 -16.339 8.137  1.00 13.57 ? 129 ARG   B CA   1 
ATOM   4405 C C    . ARG   B 1 149 ? 24.154 -17.763 7.889  1.00 16.71 ? 129 ARG   B C    1 
ATOM   4406 O O    . ARG   B 1 149 ? 24.934 -18.710 8.019  1.00 17.00 ? 129 ARG   B O    1 
ATOM   4407 C CB   . ARG   B 1 149 ? 25.371 -15.784 6.930  1.00 15.21 ? 129 ARG   B CB   1 
ATOM   4408 C CG   . ARG   B 1 149 ? 25.782 -14.337 7.135  1.00 15.36 ? 129 ARG   B CG   1 
ATOM   4409 C CD   . ARG   B 1 149 ? 26.352 -13.757 5.872  1.00 18.24 ? 129 ARG   B CD   1 
ATOM   4410 N NE   . ARG   B 1 149 ? 25.306 -13.536 4.885  1.00 19.45 ? 129 ARG   B NE   1 
ATOM   4411 C CZ   . ARG   B 1 149 ? 25.513 -12.990 3.697  1.00 24.19 ? 129 ARG   B CZ   1 
ATOM   4412 N NH1  . ARG   B 1 149 ? 26.730 -12.668 3.290  1.00 24.83 ? 129 ARG   B NH1  1 
ATOM   4413 N NH2  . ARG   B 1 149 ? 24.473 -12.758 2.902  1.00 23.68 ? 129 ARG   B NH2  1 
ATOM   4414 H H    . ARG   B 1 149 ? 26.200 -16.770 9.240  1.00 16.70 ? 129 ARG   B H    1 
ATOM   4415 H HA   . ARG   B 1 149 ? 23.851 -15.773 8.270  1.00 16.30 ? 129 ARG   B HA   1 
ATOM   4416 H HB2  . ARG   B 1 149 ? 26.173 -16.309 6.780  1.00 18.26 ? 129 ARG   B HB2  1 
ATOM   4417 H HB3  . ARG   B 1 149 ? 24.795 -15.829 6.151  1.00 18.26 ? 129 ARG   B HB3  1 
ATOM   4418 H HG2  . ARG   B 1 149 ? 25.006 -13.814 7.391  1.00 18.44 ? 129 ARG   B HG2  1 
ATOM   4419 H HG3  . ARG   B 1 149 ? 26.458 -14.288 7.829  1.00 18.44 ? 129 ARG   B HG3  1 
ATOM   4420 H HD2  . ARG   B 1 149 ? 26.774 -12.906 6.069  1.00 21.91 ? 129 ARG   B HD2  1 
ATOM   4421 H HD3  . ARG   B 1 149 ? 27.003 -14.372 5.499  1.00 21.91 ? 129 ARG   B HD3  1 
ATOM   4422 H HE   . ARG   B 1 149 ? 24.504 -13.773 5.086  1.00 23.35 ? 129 ARG   B HE   1 
ATOM   4423 H HH11 . ARG   B 1 149 ? 27.406 -12.811 3.802  1.00 29.81 ? 129 ARG   B HH11 1 
ATOM   4424 H HH12 . ARG   B 1 149 ? 26.844 -12.314 2.515  1.00 29.81 ? 129 ARG   B HH12 1 
ATOM   4425 H HH21 . ARG   B 1 149 ? 23.679 -12.962 3.162  1.00 28.43 ? 129 ARG   B HH21 1 
ATOM   4426 H HH22 . ARG   B 1 149 ? 24.594 -12.405 2.128  1.00 28.43 ? 129 ARG   B HH22 1 
ATOM   4427 N N    . PHE   B 1 150 ? 22.873 -17.906 7.560  1.00 16.39 ? 130 PHE   B N    1 
ATOM   4428 C CA   . PHE   B 1 150 ? 22.205 -19.193 7.468  1.00 14.51 ? 130 PHE   B CA   1 
ATOM   4429 C C    . PHE   B 1 150 ? 21.790 -19.484 6.030  1.00 17.02 ? 130 PHE   B C    1 
ATOM   4430 O O    . PHE   B 1 150 ? 21.530 -18.576 5.232  1.00 18.03 ? 130 PHE   B O    1 
ATOM   4431 C CB   . PHE   B 1 150 ? 20.969 -19.230 8.370  1.00 15.76 ? 130 PHE   B CB   1 
ATOM   4432 C CG   . PHE   B 1 150 ? 21.303 -19.233 9.823  1.00 15.61 ? 130 PHE   B CG   1 
ATOM   4433 C CD1  . PHE   B 1 150 ? 21.586 -18.051 10.485 1.00 15.93 ? 130 PHE   B CD1  1 
ATOM   4434 C CD2  . PHE   B 1 150 ? 21.369 -20.424 10.528 1.00 16.85 ? 130 PHE   B CD2  1 
ATOM   4435 C CE1  . PHE   B 1 150 ? 21.922 -18.059 11.824 1.00 16.15 ? 130 PHE   B CE1  1 
ATOM   4436 C CE2  . PHE   B 1 150 ? 21.702 -20.438 11.869 1.00 17.10 ? 130 PHE   B CE2  1 
ATOM   4437 C CZ   . PHE   B 1 150 ? 21.977 -19.249 12.515 1.00 16.44 ? 130 PHE   B CZ   1 
ATOM   4438 H H    . PHE   B 1 150 ? 22.354 -17.245 7.380  1.00 19.69 ? 130 PHE   B H    1 
ATOM   4439 H HA   . PHE   B 1 150 ? 22.818 -19.890 7.748  1.00 17.43 ? 130 PHE   B HA   1 
ATOM   4440 H HB2  . PHE   B 1 150 ? 20.426 -18.447 8.190  1.00 18.93 ? 130 PHE   B HB2  1 
ATOM   4441 H HB3  . PHE   B 1 150 ? 20.464 -20.036 8.178  1.00 18.93 ? 130 PHE   B HB3  1 
ATOM   4442 H HD1  . PHE   B 1 150 ? 21.550 -17.245 10.023 1.00 19.13 ? 130 PHE   B HD1  1 
ATOM   4443 H HD2  . PHE   B 1 150 ? 21.186 -21.226 10.093 1.00 20.23 ? 130 PHE   B HD2  1 
ATOM   4444 H HE1  . PHE   B 1 150 ? 22.110 -17.260 12.261 1.00 19.39 ? 130 PHE   B HE1  1 
ATOM   4445 H HE2  . PHE   B 1 150 ? 21.741 -21.243 12.333 1.00 20.54 ? 130 PHE   B HE2  1 
ATOM   4446 H HZ   . PHE   B 1 150 ? 22.200 -19.252 13.418 1.00 19.74 ? 130 PHE   B HZ   1 
ATOM   4447 N N    . GLU   B 1 151 ? 21.753 -20.775 5.725  1.00 20.41 ? 131 GLU   B N    1 
ATOM   4448 C CA   . GLU   B 1 151 ? 21.254 -21.305 4.466  1.00 20.06 ? 131 GLU   B CA   1 
ATOM   4449 C C    . GLU   B 1 151 ? 20.568 -22.614 4.807  1.00 19.73 ? 131 GLU   B C    1 
ATOM   4450 O O    . GLU   B 1 151 ? 21.165 -23.480 5.457  1.00 20.66 ? 131 GLU   B O    1 
ATOM   4451 C CB   . GLU   B 1 151 ? 22.386 -21.511 3.470  1.00 20.92 ? 131 GLU   B CB   1 
ATOM   4452 C CG   . GLU   B 1 151 ? 21.982 -22.113 2.149  1.00 25.76 ? 131 GLU   B CG   1 
ATOM   4453 C CD   . GLU   B 1 151 ? 23.156 -22.156 1.193  1.00 35.00 ? 131 GLU   B CD   1 
ATOM   4454 O OE1  . GLU   B 1 151 ? 23.413 -21.137 0.525  1.00 43.90 ? 131 GLU   B OE1  1 
ATOM   4455 O OE2  . GLU   B 1 151 ? 23.838 -23.199 1.142  1.00 47.18 ? 131 GLU   B OE2  1 
ATOM   4456 H H    . GLU   B 1 151 ? 22.024 -21.393 6.258  1.00 24.50 ? 131 GLU   B H    1 
ATOM   4457 H HA   . GLU   B 1 151 ? 20.619 -20.706 4.043  1.00 24.08 ? 131 GLU   B HA   1 
ATOM   4458 H HB2  . GLU   B 1 151 ? 22.789 -20.648 3.283  1.00 25.12 ? 131 GLU   B HB2  1 
ATOM   4459 H HB3  . GLU   B 1 151 ? 23.041 -22.104 3.870  1.00 25.12 ? 131 GLU   B HB3  1 
ATOM   4460 H HG2  . GLU   B 1 151 ? 21.665 -23.019 2.290  1.00 30.92 ? 131 GLU   B HG2  1 
ATOM   4461 H HG3  . GLU   B 1 151 ? 21.280 -21.575 1.750  1.00 30.92 ? 131 GLU   B HG3  1 
ATOM   4462 N N    . ASN   B 1 152 ? 19.308 -22.744 4.412  1.00 25.41 ? 132 ASN   B N    1 
ATOM   4463 C CA   . ASN   B 1 152 ? 18.571 -23.980 4.638  1.00 27.20 ? 132 ASN   B CA   1 
ATOM   4464 C C    . ASN   B 1 152 ? 18.539 -24.357 6.113  1.00 25.45 ? 132 ASN   B C    1 
ATOM   4465 O O    . ASN   B 1 152 ? 18.607 -25.540 6.458  1.00 23.49 ? 132 ASN   B O    1 
ATOM   4466 C CB   . ASN   B 1 152 ? 19.174 -25.125 3.819  1.00 24.57 ? 132 ASN   B CB   1 
ATOM   4467 C CG   . ASN   B 1 152 ? 19.181 -24.834 2.337  1.00 42.63 ? 132 ASN   B CG   1 
ATOM   4468 O OD1  . ASN   B 1 152 ? 20.179 -25.062 1.651  1.00 48.49 ? 132 ASN   B OD1  1 
ATOM   4469 N ND2  . ASN   B 1 152 ? 18.065 -24.327 1.831  1.00 46.17 ? 132 ASN   B ND2  1 
ATOM   4470 H H    . ASN   B 1 152 ? 18.858 -22.130 4.011  1.00 30.50 ? 132 ASN   B H    1 
ATOM   4471 H HA   . ASN   B 1 152 ? 17.654 -23.844 4.354  1.00 32.65 ? 132 ASN   B HA   1 
ATOM   4472 H HB2  . ASN   B 1 152 ? 20.090 -25.270 4.103  1.00 29.50 ? 132 ASN   B HB2  1 
ATOM   4473 H HB3  . ASN   B 1 152 ? 18.650 -25.929 3.966  1.00 29.50 ? 132 ASN   B HB3  1 
ATOM   4474 H HD21 . ASN   B 1 152 ? 18.018 -24.144 0.992  1.00 55.41 ? 132 ASN   B HD21 1 
ATOM   4475 H HD22 . ASN   B 1 152 ? 17.389 -24.182 2.342  1.00 55.41 ? 132 ASN   B HD22 1 
ATOM   4476 N N    . GLY   B 1 153 ? 18.468 -23.356 6.992  1.00 20.17 ? 133 GLY   B N    1 
ATOM   4477 C CA   . GLY   B 1 153 ? 18.321 -23.617 8.404  1.00 21.39 ? 133 GLY   B CA   1 
ATOM   4478 C C    . GLY   B 1 153 ? 19.559 -24.118 9.107  1.00 18.63 ? 133 GLY   B C    1 
ATOM   4479 O O    . GLY   B 1 153 ? 19.460 -24.593 10.244 1.00 20.94 ? 133 GLY   B O    1 
ATOM   4480 H H    . GLY   B 1 153 ? 18.504 -22.522 6.787  1.00 24.21 ? 133 GLY   B H    1 
ATOM   4481 H HA2  . GLY   B 1 153 ? 18.049 -22.795 8.842  1.00 25.68 ? 133 GLY   B HA2  1 
ATOM   4482 H HA3  . GLY   B 1 153 ? 17.627 -24.283 8.524  1.00 25.68 ? 133 GLY   B HA3  1 
ATOM   4483 N N    . LEU   B 1 154 ? 20.711 -24.050 8.459  1.00 17.50 ? 134 LEU   B N    1 
ATOM   4484 C CA   . LEU   B 1 154 ? 21.984 -24.370 9.074  1.00 19.87 ? 134 LEU   B CA   1 
ATOM   4485 C C    . LEU   B 1 154 ? 22.933 -23.203 8.844  1.00 15.47 ? 134 LEU   B C    1 
ATOM   4486 O O    . LEU   B 1 154 ? 22.686 -22.329 8.006  1.00 17.41 ? 134 LEU   B O    1 
ATOM   4487 C CB   . LEU   B 1 154 ? 22.566 -25.659 8.498  1.00 19.99 ? 134 LEU   B CB   1 
ATOM   4488 C CG   . LEU   B 1 154 ? 21.810 -26.922 8.912  1.00 25.82 ? 134 LEU   B CG   1 
ATOM   4489 C CD1  . LEU   B 1 154 ? 22.314 -28.096 8.089  1.00 28.50 ? 134 LEU   B CD1  1 
ATOM   4490 C CD2  . LEU   B 1 154 ? 21.967 -27.192 10.395 1.00 29.05 ? 134 LEU   B CD2  1 
ATOM   4491 H H    . LEU   B 1 154 ? 20.782 -23.813 7.636  1.00 21.01 ? 134 LEU   B H    1 
ATOM   4492 H HA   . LEU   B 1 154 ? 21.880 -24.496 10.030 1.00 23.86 ? 134 LEU   B HA   1 
ATOM   4493 H HB2  . LEU   B 1 154 ? 22.544 -25.605 7.530  1.00 24.00 ? 134 LEU   B HB2  1 
ATOM   4494 H HB3  . LEU   B 1 154 ? 23.482 -25.750 8.804  1.00 24.00 ? 134 LEU   B HB3  1 
ATOM   4495 H HG   . LEU   B 1 154 ? 20.862 -26.804 8.746  1.00 31.00 ? 134 LEU   B HG   1 
ATOM   4496 H HD11 . LEU   B 1 154 ? 21.842 -28.899 8.362  1.00 34.21 ? 134 LEU   B HD11 1 
ATOM   4497 H HD12 . LEU   B 1 154 ? 22.147 -27.919 7.150  1.00 34.21 ? 134 LEU   B HD12 1 
ATOM   4498 H HD13 . LEU   B 1 154 ? 23.266 -28.204 8.242  1.00 34.21 ? 134 LEU   B HD13 1 
ATOM   4499 H HD21 . LEU   B 1 154 ? 21.548 -28.040 10.608 1.00 34.87 ? 134 LEU   B HD21 1 
ATOM   4500 H HD22 . LEU   B 1 154 ? 22.912 -27.226 10.612 1.00 34.87 ? 134 LEU   B HD22 1 
ATOM   4501 H HD23 . LEU   B 1 154 ? 21.539 -26.478 10.893 1.00 34.87 ? 134 LEU   B HD23 1 
ATOM   4502 N N    . ILE   B 1 155 ? 24.018 -23.181 9.613  1.00 17.35 ? 135 ILE   B N    1 
ATOM   4503 C CA   . ILE   B 1 155 ? 24.973 -22.086 9.509  1.00 16.96 ? 135 ILE   B CA   1 
ATOM   4504 C C    . ILE   B 1 155 ? 25.810 -22.273 8.254  1.00 17.62 ? 135 ILE   B C    1 
ATOM   4505 O O    . ILE   B 1 155 ? 26.523 -23.274 8.103  1.00 17.64 ? 135 ILE   B O    1 
ATOM   4506 C CB   . ILE   B 1 155 ? 25.876 -22.017 10.742 1.00 15.19 ? 135 ILE   B CB   1 
ATOM   4507 C CG1  . ILE   B 1 155 ? 25.068 -21.885 12.020 1.00 15.35 ? 135 ILE   B CG1  1 
ATOM   4508 C CG2  . ILE   B 1 155 ? 26.845 -20.834 10.604 1.00 16.03 ? 135 ILE   B CG2  1 
ATOM   4509 C CD1  . ILE   B 1 155 ? 25.918 -22.030 13.271 1.00 16.12 ? 135 ILE   B CD1  1 
ATOM   4510 H H    . ILE   B 1 155 ? 24.220 -23.781 10.195 1.00 20.84 ? 135 ILE   B H    1 
ATOM   4511 H HA   . ILE   B 1 155 ? 24.478 -21.256 9.437  1.00 20.37 ? 135 ILE   B HA   1 
ATOM   4512 H HB   . ILE   B 1 155 ? 26.376 -22.846 10.796 1.00 18.24 ? 135 ILE   B HB   1 
ATOM   4513 H HG12 . ILE   B 1 155 ? 24.650 -21.010 12.040 1.00 18.43 ? 135 ILE   B HG12 1 
ATOM   4514 H HG13 . ILE   B 1 155 ? 24.388 -22.577 12.037 1.00 18.43 ? 135 ILE   B HG13 1 
ATOM   4515 H HG21 . ILE   B 1 155 ? 27.318 -20.712 11.442 1.00 19.25 ? 135 ILE   B HG21 1 
ATOM   4516 H HG22 . ILE   B 1 155 ? 27.476 -21.024 9.892  1.00 19.25 ? 135 ILE   B HG22 1 
ATOM   4517 H HG23 . ILE   B 1 155 ? 26.338 -20.034 10.391 1.00 19.25 ? 135 ILE   B HG23 1 
ATOM   4518 H HD11 . ILE   B 1 155 ? 25.341 -22.004 14.050 1.00 19.35 ? 135 ILE   B HD11 1 
ATOM   4519 H HD12 . ILE   B 1 155 ? 26.390 -22.877 13.236 1.00 19.35 ? 135 ILE   B HD12 1 
ATOM   4520 H HD13 . ILE   B 1 155 ? 26.554 -21.298 13.307 1.00 19.35 ? 135 ILE   B HD13 1 
ATOM   4521 N N    . LYS   B 1 156 ? 25.746 -21.289 7.362  1.00 15.77 ? 136 LYS   B N    1 
ATOM   4522 C CA   . LYS   B 1 156 ? 26.601 -21.231 6.188  1.00 15.10 ? 136 LYS   B CA   1 
ATOM   4523 C C    . LYS   B 1 156 ? 27.900 -20.488 6.457  1.00 16.41 ? 136 LYS   B C    1 
ATOM   4524 O O    . LYS   B 1 156 ? 28.938 -20.839 5.888  1.00 18.22 ? 136 LYS   B O    1 
ATOM   4525 C CB   . LYS   B 1 156 ? 25.850 -20.554 5.041  1.00 20.60 ? 136 LYS   B CB   1 
ATOM   4526 C CG   . LYS   B 1 156 ? 26.667 -20.312 3.790  1.00 26.49 ? 136 LYS   B CG   1 
ATOM   4527 C CD   . LYS   B 1 156 ? 26.576 -21.481 2.819  1.00 47.18 ? 136 LYS   B CD   1 
ATOM   4528 C CE   . LYS   B 1 156 ? 27.076 -21.084 1.436  1.00 42.85 ? 136 LYS   B CE   1 
ATOM   4529 N NZ   . LYS   B 1 156 ? 26.867 -22.165 0.430  1.00 58.68 ? 136 LYS   B NZ   1 
ATOM   4530 H H    . LYS   B 1 156 ? 25.200 -20.626 7.418  1.00 18.94 ? 136 LYS   B H    1 
ATOM   4531 H HA   . LYS   B 1 156 ? 26.827 -22.132 5.909  1.00 18.13 ? 136 LYS   B HA   1 
ATOM   4532 H HB2  . LYS   B 1 156 ? 25.100 -21.116 4.793  1.00 24.74 ? 136 LYS   B HB2  1 
ATOM   4533 H HB3  . LYS   B 1 156 ? 25.531 -19.692 5.350  1.00 24.74 ? 136 LYS   B HB3  1 
ATOM   4534 H HG2  . LYS   B 1 156 ? 26.338 -19.518 3.341  1.00 31.80 ? 136 LYS   B HG2  1 
ATOM   4535 H HG3  . LYS   B 1 156 ? 27.599 -20.192 4.034  1.00 31.80 ? 136 LYS   B HG3  1 
ATOM   4536 H HD2  . LYS   B 1 156 ? 27.121 -22.215 3.144  1.00 56.63 ? 136 LYS   B HD2  1 
ATOM   4537 H HD3  . LYS   B 1 156 ? 25.651 -21.765 2.742  1.00 56.63 ? 136 LYS   B HD3  1 
ATOM   4538 H HE2  . LYS   B 1 156 ? 26.595 -20.296 1.137  1.00 51.43 ? 136 LYS   B HE2  1 
ATOM   4539 H HE3  . LYS   B 1 156 ? 28.026 -20.894 1.482  1.00 51.43 ? 136 LYS   B HE3  1 
ATOM   4540 H HZ1  . LYS   B 1 156 ? 27.211 -21.922 -0.354 1.00 70.43 ? 136 LYS   B HZ1  1 
ATOM   4541 H HZ2  . LYS   B 1 156 ? 27.264 -22.913 0.701  1.00 70.43 ? 136 LYS   B HZ2  1 
ATOM   4542 H HZ3  . LYS   B 1 156 ? 25.997 -22.321 0.327  1.00 70.43 ? 136 LYS   B HZ3  1 
ATOM   4543 N N    . GLU   B 1 157 ? 27.870 -19.461 7.299  1.00 16.03 ? 137 GLU   B N    1 
ATOM   4544 C CA   . GLU   B 1 157 ? 29.081 -18.713 7.593  1.00 13.55 ? 137 GLU   B CA   1 
ATOM   4545 C C    . GLU   B 1 157 ? 29.011 -18.167 9.004  1.00 12.73 ? 137 GLU   B C    1 
ATOM   4546 O O    . GLU   B 1 157 ? 28.097 -17.409 9.334  1.00 15.53 ? 137 GLU   B O    1 
ATOM   4547 C CB   . GLU   B 1 157 ? 29.283 -17.572 6.601  1.00 15.99 ? 137 GLU   B CB   1 
ATOM   4548 C CG   . GLU   B 1 157 ? 30.549 -16.787 6.844  1.00 15.75 ? 137 GLU   B CG   1 
ATOM   4549 C CD   . GLU   B 1 157 ? 30.559 -15.489 6.096  1.00 23.58 ? 137 GLU   B CD   1 
ATOM   4550 O OE1  . GLU   B 1 157 ? 29.742 -14.602 6.435  1.00 17.75 ? 137 GLU   B OE1  1 
ATOM   4551 O OE2  . GLU   B 1 157 ? 31.358 -15.362 5.137  1.00 24.30 ? 137 GLU   B OE2  1 
ATOM   4552 H H    . GLU   B 1 157 ? 27.167 -19.182 7.708  1.00 19.25 ? 137 GLU   B H    1 
ATOM   4553 H HA   . GLU   B 1 157 ? 29.836 -19.319 7.536  1.00 16.27 ? 137 GLU   B HA   1 
ATOM   4554 H HB2  . GLU   B 1 157 ? 29.328 -17.939 5.704  1.00 19.20 ? 137 GLU   B HB2  1 
ATOM   4555 H HB3  . GLU   B 1 157 ? 28.535 -16.959 6.671  1.00 19.20 ? 137 GLU   B HB3  1 
ATOM   4556 H HG2  . GLU   B 1 157 ? 30.626 -16.592 7.791  1.00 18.91 ? 137 GLU   B HG2  1 
ATOM   4557 H HG3  . GLU   B 1 157 ? 31.311 -17.312 6.551  1.00 18.91 ? 137 GLU   B HG3  1 
ATOM   4558 N N    . GLN   B 1 158 ? 29.986 -18.540 9.813  1.00 13.94 ? 138 GLN   B N    1 
ATOM   4559 C CA   . GLN   B 1 158 ? 30.169 -17.991 11.144 1.00 13.02 ? 138 GLN   B CA   1 
ATOM   4560 C C    . GLN   B 1 158 ? 31.486 -17.233 11.160 1.00 14.67 ? 138 GLN   B C    1 
ATOM   4561 O O    . GLN   B 1 158 ? 32.512 -17.759 10.717 1.00 15.25 ? 138 GLN   B O    1 
ATOM   4562 C CB   . GLN   B 1 158 ? 30.160 -19.103 12.191 1.00 12.94 ? 138 GLN   B CB   1 
ATOM   4563 C CG   . GLN   B 1 158 ? 30.379 -18.611 13.606 1.00 15.72 ? 138 GLN   B CG   1 
ATOM   4564 C CD   . GLN   B 1 158 ? 31.845 -18.566 13.977 1.00 16.29 ? 138 GLN   B CD   1 
ATOM   4565 O OE1  . GLN   B 1 158 ? 32.663 -19.292 13.385 1.00 21.39 ? 138 GLN   B OE1  1 
ATOM   4566 N NE2  . GLN   B 1 158 ? 32.194 -17.741 14.936 1.00 20.50 ? 138 GLN   B NE2  1 
ATOM   4567 H H    . GLN   B 1 158 ? 30.576 -19.131 9.605  1.00 16.75 ? 138 GLN   B H    1 
ATOM   4568 H HA   . GLN   B 1 158 ? 29.453 -17.376 11.369 1.00 15.63 ? 138 GLN   B HA   1 
ATOM   4569 H HB2  . GLN   B 1 158 ? 29.299 -19.550 12.163 1.00 15.54 ? 138 GLN   B HB2  1 
ATOM   4570 H HB3  . GLN   B 1 158 ? 30.868 -19.732 11.983 1.00 15.54 ? 138 GLN   B HB3  1 
ATOM   4571 H HG2  . GLN   B 1 158 ? 30.019 -17.714 13.690 1.00 18.87 ? 138 GLN   B HG2  1 
ATOM   4572 H HG3  . GLN   B 1 158 ? 29.930 -19.208 14.224 1.00 18.87 ? 138 GLN   B HG3  1 
ATOM   4573 H HE21 . GLN   B 1 158 ? 31.599 -17.256 15.324 1.00 24.61 ? 138 GLN   B HE21 1 
ATOM   4574 H HE22 . GLN   B 1 158 ? 33.018 -17.686 15.177 1.00 24.61 ? 138 GLN   B HE22 1 
ATOM   4575 N N    . ARG   B 1 159 ? 31.459 -15.994 11.644 1.00 12.56 ? 139 ARG   B N    1 
ATOM   4576 C CA   . ARG   B 1 159 ? 32.670 -15.196 11.721 1.00 13.13 ? 139 ARG   B CA   1 
ATOM   4577 C C    . ARG   B 1 159 ? 32.750 -14.614 13.114 1.00 14.07 ? 139 ARG   B C    1 
ATOM   4578 O O    . ARG   B 1 159 ? 31.766 -14.060 13.597 1.00 13.90 ? 139 ARG   B O    1 
ATOM   4579 C CB   . ARG   B 1 159 ? 32.671 -14.071 10.703 1.00 13.22 ? 139 ARG   B CB   1 
ATOM   4580 C CG   . ARG   B 1 159 ? 32.483 -14.509 9.276  1.00 13.05 ? 139 ARG   B CG   1 
ATOM   4581 C CD   . ARG   B 1 159 ? 32.378 -13.312 8.358  1.00 14.92 ? 139 ARG   B CD   1 
ATOM   4582 N NE   . ARG   B 1 159 ? 31.178 -12.527 8.608  1.00 14.22 ? 139 ARG   B NE   1 
ATOM   4583 C CZ   . ARG   B 1 159 ? 31.041 -11.245 8.304  1.00 12.88 ? 139 ARG   B CZ   1 
ATOM   4584 N NH1  . ARG   B 1 159 ? 32.005 -10.567 7.718  1.00 13.60 ? 139 ARG   B NH1  1 
ATOM   4585 N NH2  . ARG   B 1 159 ? 29.908 -10.623 8.602  1.00 12.22 ? 139 ARG   B NH2  1 
ATOM   4586 H H    . ARG   B 1 159 ? 30.752 -15.599 11.933 1.00 15.09 ? 139 ARG   B H    1 
ATOM   4587 H HA   . ARG   B 1 159 ? 33.443 -15.756 11.548 1.00 15.77 ? 139 ARG   B HA   1 
ATOM   4588 H HB2  . ARG   B 1 159 ? 31.949 -13.461 10.918 1.00 15.87 ? 139 ARG   B HB2  1 
ATOM   4589 H HB3  . ARG   B 1 159 ? 33.523 -13.609 10.756 1.00 15.87 ? 139 ARG   B HB3  1 
ATOM   4590 H HG2  . ARG   B 1 159 ? 33.243 -15.044 8.998  1.00 15.67 ? 139 ARG   B HG2  1 
ATOM   4591 H HG3  . ARG   B 1 159 ? 31.667 -15.027 9.201  1.00 15.67 ? 139 ARG   B HG3  1 
ATOM   4592 H HD2  . ARG   B 1 159 ? 33.148 -12.738 8.494  1.00 17.92 ? 139 ARG   B HD2  1 
ATOM   4593 H HD3  . ARG   B 1 159 ? 32.352 -13.619 7.438  1.00 17.92 ? 139 ARG   B HD3  1 
ATOM   4594 H HE   . ARG   B 1 159 ? 30.511 -12.923 8.979  1.00 17.08 ? 139 ARG   B HE   1 
ATOM   4595 H HH11 . ARG   B 1 159 ? 31.894 -9.736  7.531  1.00 16.33 ? 139 ARG   B HH11 1 
ATOM   4596 H HH12 . ARG   B 1 159 ? 32.747 -10.957 7.524  1.00 16.33 ? 139 ARG   B HH12 1 
ATOM   4597 H HH21 . ARG   B 1 159 ? 29.810 -9.791  8.408  1.00 14.68 ? 139 ARG   B HH21 1 
ATOM   4598 H HH22 . ARG   B 1 159 ? 29.271 -11.052 8.989  1.00 14.68 ? 139 ARG   B HH22 1 
ATOM   4599 N N    . GLU   B 1 160 ? 33.907 -14.706 13.751 1.00 12.56 ? 140 GLU   B N    1 
ATOM   4600 C CA   . GLU   B 1 160 ? 34.078 -14.037 15.028 1.00 11.65 ? 140 GLU   B CA   1 
ATOM   4601 C C    . GLU   B 1 160 ? 35.072 -12.895 14.915 1.00 12.45 ? 140 GLU   B C    1 
ATOM   4602 O O    . GLU   B 1 160 ? 36.084 -12.990 14.202 1.00 15.06 ? 140 GLU   B O    1 
ATOM   4603 C CB   . GLU   B 1 160 ? 34.511 -14.981 16.151 1.00 22.69 ? 140 GLU   B CB   1 
ATOM   4604 C CG   . GLU   B 1 160 ? 35.423 -16.110 15.828 1.00 29.92 ? 140 GLU   B CG   1 
ATOM   4605 C CD   . GLU   B 1 160 ? 35.363 -17.124 16.958 1.00 29.14 ? 140 GLU   B CD   1 
ATOM   4606 O OE1  . GLU   B 1 160 ? 36.012 -16.879 17.992 1.00 21.44 ? 140 GLU   B OE1  1 
ATOM   4607 O OE2  . GLU   B 1 160 ? 34.604 -18.099 16.826 1.00 30.77 ? 140 GLU   B OE2  1 
ATOM   4608 H H    . GLU   B 1 160 ? 34.593 -15.140 13.468 1.00 15.08 ? 140 GLU   B H    1 
ATOM   4609 H HA   . GLU   B 1 160 ? 33.213 -13.672 15.275 1.00 14.00 ? 140 GLU   B HA   1 
ATOM   4610 H HB2  . GLU   B 1 160 ? 34.964 -14.446 16.822 1.00 27.24 ? 140 GLU   B HB2  1 
ATOM   4611 H HB3  . GLU   B 1 160 ? 33.709 -15.375 16.527 1.00 27.24 ? 140 GLU   B HB3  1 
ATOM   4612 H HG2  . GLU   B 1 160 ? 35.141 -16.538 15.004 1.00 35.92 ? 140 GLU   B HG2  1 
ATOM   4613 H HG3  . GLU   B 1 160 ? 36.333 -15.787 15.740 1.00 35.92 ? 140 GLU   B HG3  1 
ATOM   4614 N N    . PHE   B 1 161 ? 34.736 -11.803 15.600 1.00 13.36 ? 141 PHE   B N    1 
ATOM   4615 C CA   . PHE   B 1 161 ? 35.528 -10.585 15.650 1.00 12.43 ? 141 PHE   B CA   1 
ATOM   4616 C C    . PHE   B 1 161 ? 35.844 -10.279 17.098 1.00 12.64 ? 141 PHE   B C    1 
ATOM   4617 O O    . PHE   B 1 161 ? 34.937 -10.209 17.925 1.00 14.34 ? 141 PHE   B O    1 
ATOM   4618 C CB   . PHE   B 1 161 ? 34.756 -9.406  15.056 1.00 12.22 ? 141 PHE   B CB   1 
ATOM   4619 C CG   . PHE   B 1 161 ? 34.311 -9.612  13.634 1.00 12.14 ? 141 PHE   B CG   1 
ATOM   4620 C CD1  . PHE   B 1 161 ? 33.194 -10.371 13.349 1.00 13.91 ? 141 PHE   B CD1  1 
ATOM   4621 C CD2  . PHE   B 1 161 ? 35.006 -9.023  12.591 1.00 14.77 ? 141 PHE   B CD2  1 
ATOM   4622 C CE1  . PHE   B 1 161 ? 32.787 -10.548 12.044 1.00 15.72 ? 141 PHE   B CE1  1 
ATOM   4623 C CE2  . PHE   B 1 161 ? 34.597 -9.200  11.294 1.00 17.40 ? 141 PHE   B CE2  1 
ATOM   4624 C CZ   . PHE   B 1 161 ? 33.483 -9.963  11.019 1.00 15.09 ? 141 PHE   B CZ   1 
ATOM   4625 H H    A PHE   B 1 161 ? 34.015 -11.744 16.065 0.69 16.05 ? 141 PHE   B H    1 
ATOM   4626 H H    B PHE   B 1 161 ? 34.015 -11.744 16.065 0.31 16.05 ? 141 PHE   B H    1 
ATOM   4627 H HA   . PHE   B 1 161 ? 36.351 -10.710 15.152 1.00 14.93 ? 141 PHE   B HA   1 
ATOM   4628 H HB2  . PHE   B 1 161 ? 33.963 -9.253  15.593 1.00 14.67 ? 141 PHE   B HB2  1 
ATOM   4629 H HB3  . PHE   B 1 161 ? 35.326 -8.621  15.075 1.00 14.67 ? 141 PHE   B HB3  1 
ATOM   4630 H HD1  . PHE   B 1 161 ? 32.714 -10.765 14.041 1.00 16.71 ? 141 PHE   B HD1  1 
ATOM   4631 H HD2  . PHE   B 1 161 ? 35.756 -8.503  12.771 1.00 17.74 ? 141 PHE   B HD2  1 
ATOM   4632 H HE1  . PHE   B 1 161 ? 32.038 -11.067 11.858 1.00 18.87 ? 141 PHE   B HE1  1 
ATOM   4633 H HE2  . PHE   B 1 161 ? 35.073 -8.806  10.599 1.00 20.89 ? 141 PHE   B HE2  1 
ATOM   4634 H HZ   . PHE   B 1 161 ? 33.204 -10.079 10.140 1.00 18.12 ? 141 PHE   B HZ   1 
ATOM   4635 N N    . MET   B 1 162 ? 37.114 -10.083 17.398 1.00 12.90 ? 142 MET   B N    1 
ATOM   4636 C CA   . MET   B 1 162 ? 37.523 -9.727  18.739 1.00 14.29 ? 142 MET   B CA   1 
ATOM   4637 C C    . MET   B 1 162 ? 38.698 -8.772  18.614 1.00 14.33 ? 142 MET   B C    1 
ATOM   4638 O O    . MET   B 1 162 ? 39.074 -8.351  17.515 1.00 16.46 ? 142 MET   B O    1 
ATOM   4639 C CB   . MET   B 1 162 ? 37.836 -10.980 19.572 1.00 14.56 ? 142 MET   B CB   1 
ATOM   4640 C CG   . MET   B 1 162 ? 38.731 -12.019 18.919 1.00 13.66 ? 142 MET   B CG   1 
ATOM   4641 S SD   . MET   B 1 162 ? 40.367 -11.382 18.564 1.00 16.85 ? 142 MET   B SD   1 
ATOM   4642 C CE   . MET   B 1 162 ? 41.325 -12.879 18.399 1.00 16.15 ? 142 MET   B CE   1 
ATOM   4643 H H    . MET   B 1 162 ? 37.762 -10.152 16.837 1.00 15.49 ? 142 MET   B H    1 
ATOM   4644 H HA   . MET   B 1 162 ? 36.803 -9.269  19.200 1.00 17.16 ? 142 MET   B HA   1 
ATOM   4645 H HB2  . MET   B 1 162 ? 38.277 -10.696 20.388 1.00 17.48 ? 142 MET   B HB2  1 
ATOM   4646 H HB3  . MET   B 1 162 ? 36.997 -11.418 19.783 1.00 17.48 ? 142 MET   B HB3  1 
ATOM   4647 H HG2  . MET   B 1 162 ? 38.826 -12.778 19.516 1.00 16.40 ? 142 MET   B HG2  1 
ATOM   4648 H HG3  . MET   B 1 162 ? 38.330 -12.304 18.083 1.00 16.40 ? 142 MET   B HG3  1 
ATOM   4649 H HE1  . MET   B 1 162 ? 42.047 -12.725 17.770 1.00 19.40 ? 142 MET   B HE1  1 
ATOM   4650 H HE2  . MET   B 1 162 ? 41.688 -13.120 19.266 1.00 19.40 ? 142 MET   B HE2  1 
ATOM   4651 H HE3  . MET   B 1 162 ? 40.749 -13.589 18.073 1.00 19.40 ? 142 MET   B HE3  1 
ATOM   4652 N N    . ASN   B 1 163 ? 39.250 -8.391  19.760 1.00 14.54 ? 143 ASN   B N    1 
ATOM   4653 C CA   . ASN   B 1 163 ? 40.446 -7.566  19.774 1.00 15.24 ? 143 ASN   B CA   1 
ATOM   4654 C C    . ASN   B 1 163 ? 41.645 -8.485  19.924 1.00 12.60 ? 143 ASN   B C    1 
ATOM   4655 O O    . ASN   B 1 163 ? 41.854 -9.021  21.021 1.00 14.19 ? 143 ASN   B O    1 
ATOM   4656 C CB   . ASN   B 1 163 ? 40.382 -6.582  20.928 1.00 16.38 ? 143 ASN   B CB   1 
ATOM   4657 C CG   . ASN   B 1 163 ? 41.587 -5.690  20.998 1.00 14.28 ? 143 ASN   B CG   1 
ATOM   4658 O OD1  . ASN   B 1 163 ? 42.560 -5.870  20.261 1.00 15.64 ? 143 ASN   B OD1  1 
ATOM   4659 N ND2  . ASN   B 1 163 ? 41.543 -4.724  21.896 1.00 18.67 ? 143 ASN   B ND2  1 
ATOM   4660 H H    . ASN   B 1 163 ? 38.950 -8.597  20.539 1.00 17.46 ? 143 ASN   B H    1 
ATOM   4661 H HA   . ASN   B 1 163 ? 40.530 -7.070  18.945 1.00 18.30 ? 143 ASN   B HA   1 
ATOM   4662 H HB2  . ASN   B 1 163 ? 39.599 -6.020  20.822 1.00 19.67 ? 143 ASN   B HB2  1 
ATOM   4663 H HB3  . ASN   B 1 163 ? 40.325 -7.075  21.762 1.00 19.67 ? 143 ASN   B HB3  1 
ATOM   4664 H HD21 . ASN   B 1 163 ? 42.207 -4.183  21.979 1.00 22.42 ? 143 ASN   B HD21 1 
ATOM   4665 H HD22 . ASN   B 1 163 ? 40.851 -4.635  22.398 1.00 22.42 ? 143 ASN   B HD22 1 
ATOM   4666 N N    . PRO   B 1 164 ? 42.440 -8.714  18.871 1.00 12.01 ? 144 PRO   B N    1 
ATOM   4667 C CA   . PRO   B 1 164 ? 43.572 -9.647  19.013 1.00 13.79 ? 144 PRO   B CA   1 
ATOM   4668 C C    . PRO   B 1 164 ? 44.556 -9.232  20.079 1.00 15.33 ? 144 PRO   B C    1 
ATOM   4669 O O    . PRO   B 1 164 ? 45.305 -10.083 20.558 1.00 15.05 ? 144 PRO   B O    1 
ATOM   4670 C CB   . PRO   B 1 164 ? 44.220 -9.640  17.622 1.00 16.73 ? 144 PRO   B CB   1 
ATOM   4671 C CG   . PRO   B 1 164 ? 43.159 -9.162  16.690 1.00 20.38 ? 144 PRO   B CG   1 
ATOM   4672 C CD   . PRO   B 1 164 ? 42.327 -8.189  17.494 1.00 15.11 ? 144 PRO   B CD   1 
ATOM   4673 H HA   . PRO   B 1 164 ? 43.244 -10.540 19.203 1.00 16.56 ? 144 PRO   B HA   1 
ATOM   4674 H HB2  . PRO   B 1 164 ? 44.980 -9.037  17.617 1.00 20.09 ? 144 PRO   B HB2  1 
ATOM   4675 H HB3  . PRO   B 1 164 ? 44.507 -10.536 17.388 1.00 20.09 ? 144 PRO   B HB3  1 
ATOM   4676 H HG2  . PRO   B 1 164 ? 43.565 -8.721  15.927 1.00 24.47 ? 144 PRO   B HG2  1 
ATOM   4677 H HG3  . PRO   B 1 164 ? 42.621 -9.912  16.393 1.00 24.47 ? 144 PRO   B HG3  1 
ATOM   4678 H HD2  . PRO   B 1 164 ? 42.690 -7.291  17.434 1.00 18.14 ? 144 PRO   B HD2  1 
ATOM   4679 H HD3  . PRO   B 1 164 ? 41.404 -8.194  17.196 1.00 18.14 ? 144 PRO   B HD3  1 
ATOM   4680 N N    . CYS   B 1 165 ? 44.601 -7.953  20.463 1.00 14.70 ? 145 CYS   B N    1 
ATOM   4681 C CA   . CYS   B 1 165 ? 45.576 -7.542  21.466 1.00 15.50 ? 145 CYS   B CA   1 
ATOM   4682 C C    . CYS   B 1 165 ? 45.326 -8.237  22.795 1.00 15.99 ? 145 CYS   B C    1 
ATOM   4683 O O    . CYS   B 1 165 ? 46.275 -8.512  23.534 1.00 15.39 ? 145 CYS   B O    1 
ATOM   4684 C CB   . CYS   B 1 165 ? 45.553 -6.030  21.637 1.00 16.00 ? 145 CYS   B CB   1 
ATOM   4685 S SG   . CYS   B 1 165 ? 46.060 -5.150  20.145 1.00 18.74 ? 145 CYS   B SG   1 
ATOM   4686 H H    . CYS   B 1 165 ? 44.094 -7.326  20.166 1.00 17.65 ? 145 CYS   B H    1 
ATOM   4687 H HA   . CYS   B 1 165 ? 46.464 -7.787  21.161 1.00 18.62 ? 145 CYS   B HA   1 
ATOM   4688 H HB2  . CYS   B 1 165 ? 44.651 -5.751  21.858 1.00 19.22 ? 145 CYS   B HB2  1 
ATOM   4689 H HB3  . CYS   B 1 165 ? 46.161 -5.784  22.351 1.00 19.22 ? 145 CYS   B HB3  1 
ATOM   4690 H HG   . CYS   B 1 165 ? 45.348 -5.479  19.237 1.00 22.50 ? 145 CYS   B HG   1 
ATOM   4691 N N    . GLU   B 1 166 ? 44.065 -8.535  23.122 1.00 15.05 ? 146 GLU   B N    1 
ATOM   4692 C CA   . GLU   B 1 166 ? 43.787 -9.269  24.352 1.00 17.80 ? 146 GLU   B CA   1 
ATOM   4693 C C    . GLU   B 1 166 ? 44.281 -10.704 24.264 1.00 16.66 ? 146 GLU   B C    1 
ATOM   4694 O O    . GLU   B 1 166 ? 44.723 -11.267 25.267 1.00 16.33 ? 146 GLU   B O    1 
ATOM   4695 C CB   . GLU   B 1 166 ? 42.291 -9.231  24.653 1.00 16.01 ? 146 GLU   B CB   1 
ATOM   4696 C CG   . GLU   B 1 166 ? 41.819 -7.857  25.101 1.00 20.22 ? 146 GLU   B CG   1 
ATOM   4697 C CD   . GLU   B 1 166 ? 42.584 -7.341  26.320 1.00 29.83 ? 146 GLU   B CD   1 
ATOM   4698 O OE1  . GLU   B 1 166 ? 42.677 -8.077  27.323 1.00 42.05 ? 146 GLU   B OE1  1 
ATOM   4699 O OE2  . GLU   B 1 166 ? 43.095 -6.206  26.252 1.00 39.07 ? 146 GLU   B OE2  1 
ATOM   4700 H H    . GLU   B 1 166 ? 43.371 -8.328  22.659 1.00 18.08 ? 146 GLU   B H    1 
ATOM   4701 H HA   . GLU   B 1 166 ? 44.249 -8.840  25.089 1.00 21.37 ? 146 GLU   B HA   1 
ATOM   4702 H HB2  . GLU   B 1 166 ? 41.801 -9.470  23.851 1.00 19.23 ? 146 GLU   B HB2  1 
ATOM   4703 H HB3  . GLU   B 1 166 ? 42.095 -9.862  25.363 1.00 19.23 ? 146 GLU   B HB3  1 
ATOM   4704 H HG2  . GLU   B 1 166 ? 41.948 -7.225  24.376 1.00 24.27 ? 146 GLU   B HG2  1 
ATOM   4705 H HG3  . GLU   B 1 166 ? 40.879 -7.905  25.335 1.00 24.27 ? 146 GLU   B HG3  1 
ATOM   4706 N N    . GLN   B 1 167 ? 44.223 -11.315 23.086 1.00 15.02 ? 147 GLN   B N    1 
ATOM   4707 C CA   . GLN   B 1 167 ? 44.809 -12.645 22.955 1.00 14.41 ? 147 GLN   B CA   1 
ATOM   4708 C C    . GLN   B 1 167 ? 46.328 -12.574 23.033 1.00 15.82 ? 147 GLN   B C    1 
ATOM   4709 O O    . GLN   B 1 167 ? 46.956 -13.423 23.672 1.00 16.29 ? 147 GLN   B O    1 
ATOM   4710 C CB   . GLN   B 1 167 ? 44.358 -13.318 21.659 1.00 13.69 ? 147 GLN   B CB   1 
ATOM   4711 C CG   . GLN   B 1 167 ? 44.637 -14.807 21.668 1.00 16.47 ? 147 GLN   B CG   1 
ATOM   4712 C CD   . GLN   B 1 167 ? 43.996 -15.537 20.512 1.00 21.70 ? 147 GLN   B CD   1 
ATOM   4713 O OE1  . GLN   B 1 167 ? 43.030 -15.065 19.918 1.00 20.19 ? 147 GLN   B OE1  1 
ATOM   4714 N NE2  . GLN   B 1 167 ? 44.533 -16.706 20.187 1.00 23.04 ? 147 GLN   B NE2  1 
ATOM   4715 H H    . GLN   B 1 167 ? 43.865 -10.994 22.373 1.00 18.04 ? 147 GLN   B H    1 
ATOM   4716 H HA   . GLN   B 1 167 ? 44.490 -13.198 23.685 1.00 17.31 ? 147 GLN   B HA   1 
ATOM   4717 H HB2  . GLN   B 1 167 ? 43.403 -13.189 21.548 1.00 16.45 ? 147 GLN   B HB2  1 
ATOM   4718 H HB3  . GLN   B 1 167 ? 44.835 -12.923 20.912 1.00 16.45 ? 147 GLN   B HB3  1 
ATOM   4719 H HG2  . GLN   B 1 167 ? 45.596 -14.947 21.614 1.00 19.78 ? 147 GLN   B HG2  1 
ATOM   4720 H HG3  . GLN   B 1 167 ? 44.291 -15.187 22.490 1.00 19.78 ? 147 GLN   B HG3  1 
ATOM   4721 H HE21 . GLN   B 1 167 ? 45.208 -17.006 20.627 1.00 27.66 ? 147 GLN   B HE21 1 
ATOM   4722 H HE22 . GLN   B 1 167 ? 44.206 -17.164 19.536 1.00 27.66 ? 147 GLN   B HE22 1 
ATOM   4723 N N    . PHE   B 1 168 ? 46.944 -11.572 22.403 1.00 14.30 ? 148 PHE   B N    1 
ATOM   4724 C CA   . PHE   B 1 168 ? 48.382 -11.389 22.567 1.00 15.95 ? 148 PHE   B CA   1 
ATOM   4725 C C    . PHE   B 1 168 ? 48.746 -11.350 24.041 1.00 17.65 ? 148 PHE   B C    1 
ATOM   4726 O O    . PHE   B 1 168 ? 49.646 -12.063 24.493 1.00 17.42 ? 148 PHE   B O    1 
ATOM   4727 C CB   . PHE   B 1 168 ? 48.877 -10.112 21.875 1.00 14.82 ? 148 PHE   B CB   1 
ATOM   4728 C CG   . PHE   B 1 168 ? 48.583 -10.040 20.408 1.00 16.17 ? 148 PHE   B CG   1 
ATOM   4729 C CD1  . PHE   B 1 168 ? 48.397 -11.179 19.655 1.00 17.69 ? 148 PHE   B CD1  1 
ATOM   4730 C CD2  . PHE   B 1 168 ? 48.493 -8.803  19.782 1.00 18.17 ? 148 PHE   B CD2  1 
ATOM   4731 C CE1  . PHE   B 1 168 ? 48.125 -11.092 18.300 1.00 19.90 ? 148 PHE   B CE1  1 
ATOM   4732 C CE2  . PHE   B 1 168 ? 48.217 -8.712  18.433 1.00 20.49 ? 148 PHE   B CE2  1 
ATOM   4733 C CZ   . PHE   B 1 168 ? 48.033 -9.857  17.693 1.00 21.90 ? 148 PHE   B CZ   1 
ATOM   4734 H H    . PHE   B 1 168 ? 46.560 -11.000 21.888 1.00 17.18 ? 148 PHE   B H    1 
ATOM   4735 H HA   . PHE   B 1 168 ? 48.826 -12.137 22.138 1.00 19.15 ? 148 PHE   B HA   1 
ATOM   4736 H HB2  . PHE   B 1 168 ? 48.451 -9.348  22.296 1.00 17.80 ? 148 PHE   B HB2  1 
ATOM   4737 H HB3  . PHE   B 1 168 ? 49.839 -10.056 21.983 1.00 17.80 ? 148 PHE   B HB3  1 
ATOM   4738 H HD1  . PHE   B 1 168 ? 48.454 -12.014 20.060 1.00 21.24 ? 148 PHE   B HD1  1 
ATOM   4739 H HD2  . PHE   B 1 168 ? 48.621 -8.027  20.278 1.00 21.82 ? 148 PHE   B HD2  1 
ATOM   4740 H HE1  . PHE   B 1 168 ? 48.005 -11.867 17.799 1.00 23.90 ? 148 PHE   B HE1  1 
ATOM   4741 H HE2  . PHE   B 1 168 ? 48.155 -7.879  18.025 1.00 24.60 ? 148 PHE   B HE2  1 
ATOM   4742 H HZ   . PHE   B 1 168 ? 47.846 -9.798  16.784 1.00 26.30 ? 148 PHE   B HZ   1 
ATOM   4743 N N    . ARG   B 1 169 ? 48.048 -10.517 24.809 1.00 15.47 ? 149 ARG   B N    1 
ATOM   4744 C CA   . ARG   B 1 169 ? 48.357 -10.402 26.228 1.00 16.55 ? 149 ARG   B CA   1 
ATOM   4745 C C    . ARG   B 1 169 ? 48.231 -11.745 26.936 1.00 19.48 ? 149 ARG   B C    1 
ATOM   4746 O O    . ARG   B 1 169 ? 49.063 -12.084 27.787 1.00 19.56 ? 149 ARG   B O    1 
ATOM   4747 C CB   . ARG   B 1 169 ? 47.448 -9.366  26.892 1.00 20.59 ? 149 ARG   B CB   1 
ATOM   4748 C CG   . ARG   B 1 169 ? 47.980 -7.956  26.804 1.00 25.40 ? 149 ARG   B CG   1 
ATOM   4749 C CD   . ARG   B 1 169 ? 47.107 -7.003  27.580 1.00 24.19 ? 149 ARG   B CD   1 
ATOM   4750 N NE   . ARG   B 1 169 ? 46.011 -6.559  26.739 1.00 37.01 ? 149 ARG   B NE   1 
ATOM   4751 C CZ   . ARG   B 1 169 ? 46.113 -5.603  25.825 1.00 30.63 ? 149 ARG   B CZ   1 
ATOM   4752 N NH1  . ARG   B 1 169 ? 47.231 -4.918  25.666 1.00 38.00 ? 149 ARG   B NH1  1 
ATOM   4753 N NH2  . ARG   B 1 169 ? 45.067 -5.340  25.045 1.00 27.20 ? 149 ARG   B NH2  1 
ATOM   4754 H H    . ARG   B 1 169 ? 47.403 -10.018 24.538 1.00 18.57 ? 149 ARG   B H    1 
ATOM   4755 H HA   . ARG   B 1 169 ? 49.274 -10.098 26.316 1.00 19.87 ? 149 ARG   B HA   1 
ATOM   4756 H HB2  . ARG   B 1 169 ? 46.582 -9.385  26.457 1.00 24.72 ? 149 ARG   B HB2  1 
ATOM   4757 H HB3  . ARG   B 1 169 ? 47.353 -9.590  27.832 1.00 24.72 ? 149 ARG   B HB3  1 
ATOM   4758 H HG2  . ARG   B 1 169 ? 48.876 -7.924  27.175 1.00 30.50 ? 149 ARG   B HG2  1 
ATOM   4759 H HG3  . ARG   B 1 169 ? 47.995 -7.674  25.876 1.00 30.50 ? 149 ARG   B HG3  1 
ATOM   4760 H HD2  . ARG   B 1 169 ? 46.742 -7.450  28.359 1.00 29.05 ? 149 ARG   B HD2  1 
ATOM   4761 H HD3  . ARG   B 1 169 ? 47.625 -6.230  27.853 1.00 29.05 ? 149 ARG   B HD3  1 
ATOM   4762 H HE   . ARG   B 1 169 ? 45.247 -6.940  26.839 1.00 44.42 ? 149 ARG   B HE   1 
ATOM   4763 H HH11 . ARG   B 1 169 ? 47.276 -4.302  25.067 1.00 45.62 ? 149 ARG   B HH11 1 
ATOM   4764 H HH12 . ARG   B 1 169 ? 47.914 -5.087  26.160 1.00 45.62 ? 149 ARG   B HH12 1 
ATOM   4765 H HH21 . ARG   B 1 169 ? 44.338 -5.786  25.137 1.00 32.66 ? 149 ARG   B HH21 1 
ATOM   4766 H HH22 . ARG   B 1 169 ? 45.121 -4.722  24.449 1.00 32.66 ? 149 ARG   B HH22 1 
ATOM   4767 N N    . SER   B 1 170 ? 47.203 -12.529 26.597 1.00 16.10 ? 150 SER   B N    1 
ATOM   4768 C CA   . SER   B 1 170 ? 47.001 -13.803 27.280 1.00 15.75 ? 150 SER   B CA   1 
ATOM   4769 C C    . SER   B 1 170 ? 48.145 -14.766 26.999 1.00 18.86 ? 150 SER   B C    1 
ATOM   4770 O O    . SER   B 1 170 ? 48.412 -15.668 27.805 1.00 20.13 ? 150 SER   B O    1 
ATOM   4771 C CB   . SER   B 1 170 ? 45.661 -14.423 26.874 1.00 18.94 ? 150 SER   B CB   1 
ATOM   4772 O OG   . SER   B 1 170 ? 45.705 -15.020 25.580 1.00 19.49 ? 150 SER   B OG   1 
ATOM   4773 H H    . SER   B 1 170 ? 46.623 -12.348 25.988 1.00 19.33 ? 150 SER   B H    1 
ATOM   4774 H HA   . SER   B 1 170 ? 46.968 -13.643 28.236 1.00 18.91 ? 150 SER   B HA   1 
ATOM   4775 H HB2  . SER   B 1 170 ? 45.427 -15.106 27.522 1.00 22.75 ? 150 SER   B HB2  1 
ATOM   4776 H HB3  . SER   B 1 170 ? 44.986 -13.726 26.869 1.00 22.75 ? 150 SER   B HB3  1 
ATOM   4777 H HG   . SER   B 1 170 ? 44.980 -15.413 25.420 1.00 23.40 ? 150 SER   B HG   1 
ATOM   4778 N N    . LEU   B 1 171 ? 48.820 -14.595 25.864 1.00 15.58 ? 151 LEU   B N    1 
ATOM   4779 C CA   . LEU   B 1 171 ? 49.923 -15.448 25.450 1.00 18.16 ? 151 LEU   B CA   1 
ATOM   4780 C C    . LEU   B 1 171 ? 51.281 -14.885 25.847 1.00 21.04 ? 151 LEU   B C    1 
ATOM   4781 O O    . LEU   B 1 171 ? 52.308 -15.501 25.531 1.00 19.63 ? 151 LEU   B O    1 
ATOM   4782 C CB   . LEU   B 1 171 ? 49.887 -15.643 23.939 1.00 15.94 ? 151 LEU   B CB   1 
ATOM   4783 C CG   . LEU   B 1 171 ? 48.673 -16.398 23.418 1.00 19.30 ? 151 LEU   B CG   1 
ATOM   4784 C CD1  . LEU   B 1 171 ? 48.644 -16.342 21.906 1.00 21.74 ? 151 LEU   B CD1  1 
ATOM   4785 C CD2  . LEU   B 1 171 ? 48.684 -17.832 23.907 1.00 19.54 ? 151 LEU   B CD2  1 
ATOM   4786 H H    . LEU   B 1 171 ? 48.649 -13.969 25.300 1.00 18.71 ? 151 LEU   B H    1 
ATOM   4787 H HA   . LEU   B 1 171 ? 49.821 -16.315 25.872 1.00 21.80 ? 151 LEU   B HA   1 
ATOM   4788 H HB2  . LEU   B 1 171 ? 49.890 -14.770 23.517 1.00 19.14 ? 151 LEU   B HB2  1 
ATOM   4789 H HB3  . LEU   B 1 171 ? 50.676 -16.142 23.676 1.00 19.14 ? 151 LEU   B HB3  1 
ATOM   4790 H HG   . LEU   B 1 171 ? 47.864 -15.983 23.755 1.00 23.18 ? 151 LEU   B HG   1 
ATOM   4791 H HD11 . LEU   B 1 171 ? 47.886 -16.856 21.586 1.00 26.10 ? 151 LEU   B HD11 1 
ATOM   4792 H HD12 . LEU   B 1 171 ? 48.558 -15.417 21.627 1.00 26.10 ? 151 LEU   B HD12 1 
ATOM   4793 H HD13 . LEU   B 1 171 ? 49.469 -16.717 21.560 1.00 26.10 ? 151 LEU   B HD13 1 
ATOM   4794 H HD21 . LEU   B 1 171 ? 47.912 -18.294 23.547 1.00 23.46 ? 151 LEU   B HD21 1 
ATOM   4795 H HD22 . LEU   B 1 171 ? 49.499 -18.262 23.604 1.00 23.46 ? 151 LEU   B HD22 1 
ATOM   4796 H HD23 . LEU   B 1 171 ? 48.650 -17.835 24.876 1.00 23.46 ? 151 LEU   B HD23 1 
ATOM   4797 N N    . GLY   B 1 172 ? 51.313 -13.731 26.514 1.00 18.30 ? 152 GLY   B N    1 
ATOM   4798 C CA   . GLY   B 1 172 ? 52.567 -13.115 26.892 1.00 17.13 ? 152 GLY   B CA   1 
ATOM   4799 C C    . GLY   B 1 172 ? 53.266 -12.398 25.774 1.00 22.91 ? 152 GLY   B C    1 
ATOM   4800 O O    . GLY   B 1 172 ? 54.459 -12.101 25.891 1.00 23.64 ? 152 GLY   B O    1 
ATOM   4801 H H    . GLY   B 1 172 ? 50.616 -13.290 26.757 1.00 21.97 ? 152 GLY   B H    1 
ATOM   4802 H HA2  . GLY   B 1 172 ? 52.400 -12.473 27.600 1.00 20.57 ? 152 GLY   B HA2  1 
ATOM   4803 H HA3  . GLY   B 1 172 ? 53.165 -13.803 27.225 1.00 20.57 ? 152 GLY   B HA3  1 
ATOM   4804 N N    . ILE   B 1 173 ? 52.559 -12.131 24.683 1.00 19.53 ? 153 ILE   B N    1 
ATOM   4805 C CA   . ILE   B 1 173 ? 53.104 -11.431 23.530 1.00 19.91 ? 153 ILE   B CA   1 
ATOM   4806 C C    . ILE   B 1 173 ? 53.020 -9.934  23.788 1.00 22.66 ? 153 ILE   B C    1 
ATOM   4807 O O    . ILE   B 1 173 ? 51.972 -9.424  24.195 1.00 21.34 ? 153 ILE   B O    1 
ATOM   4808 C CB   . ILE   B 1 173 ? 52.342 -11.819 22.254 1.00 17.91 ? 153 ILE   B CB   1 
ATOM   4809 C CG1  . ILE   B 1 173 ? 52.476 -13.326 21.996 1.00 19.77 ? 153 ILE   B CG1  1 
ATOM   4810 C CG2  . ILE   B 1 173 ? 52.835 -11.023 21.062 1.00 21.40 ? 153 ILE   B CG2  1 
ATOM   4811 C CD1  . ILE   B 1 173 ? 51.620 -13.831 20.842 1.00 20.70 ? 153 ILE   B CD1  1 
ATOM   4812 H H    . ILE   B 1 173 ? 51.734 -12.353 24.584 1.00 23.45 ? 153 ILE   B H    1 
ATOM   4813 H HA   . ILE   B 1 173 ? 54.038 -11.668 23.413 1.00 23.91 ? 153 ILE   B HA   1 
ATOM   4814 H HB   . ILE   B 1 173 ? 51.405 -11.608 22.385 1.00 21.51 ? 153 ILE   B HB   1 
ATOM   4815 H HG12 . ILE   B 1 173 ? 53.402 -13.525 21.786 1.00 23.74 ? 153 ILE   B HG12 1 
ATOM   4816 H HG13 . ILE   B 1 173 ? 52.206 -13.804 22.795 1.00 23.74 ? 153 ILE   B HG13 1 
ATOM   4817 H HG21 . ILE   B 1 173 ? 52.377 -11.333 20.265 1.00 25.70 ? 153 ILE   B HG21 1 
ATOM   4818 H HG22 . ILE   B 1 173 ? 52.645 -10.084 21.210 1.00 25.70 ? 153 ILE   B HG22 1 
ATOM   4819 H HG23 . ILE   B 1 173 ? 53.791 -11.157 20.967 1.00 25.70 ? 153 ILE   B HG23 1 
ATOM   4820 H HD11 . ILE   B 1 173 ? 51.469 -14.783 20.955 1.00 24.86 ? 153 ILE   B HD11 1 
ATOM   4821 H HD12 . ILE   B 1 173 ? 50.773 -13.359 20.847 1.00 24.86 ? 153 ILE   B HD12 1 
ATOM   4822 H HD13 . ILE   B 1 173 ? 52.086 -13.666 20.008 1.00 24.86 ? 153 ILE   B HD13 1 
ATOM   4823 N N    . GLU   B 1 174 ? 54.130 -9.232  23.583 1.00 23.26 ? 154 GLU   B N    1 
ATOM   4824 C CA   . GLU   B 1 174 ? 54.149 -7.795  23.812 1.00 25.42 ? 154 GLU   B CA   1 
ATOM   4825 C C    . GLU   B 1 174 ? 53.243 -7.091  22.814 1.00 19.21 ? 154 GLU   B C    1 
ATOM   4826 O O    . GLU   B 1 174 ? 53.219 -7.427  21.630 1.00 21.31 ? 154 GLU   B O    1 
ATOM   4827 C CB   . GLU   B 1 174 ? 55.577 -7.258  23.696 1.00 28.51 ? 154 GLU   B CB   1 
ATOM   4828 C CG   . GLU   B 1 174 ? 55.694 -5.781  23.981 1.00 39.50 ? 154 GLU   B CG   1 
ATOM   4829 C CD   . GLU   B 1 174 ? 57.064 -5.401  24.490 1.00 70.81 ? 154 GLU   B CD   1 
ATOM   4830 O OE1  . GLU   B 1 174 ? 58.009 -6.197  24.307 1.00 56.32 ? 154 GLU   B OE1  1 
ATOM   4831 O OE2  . GLU   B 1 174 ? 57.195 -4.311  25.082 1.00 89.32 ? 154 GLU   B OE2  1 
ATOM   4832 H H    . GLU   B 1 174 ? 54.877 -9.562  23.314 1.00 27.92 ? 154 GLU   B H    1 
ATOM   4833 H HA   . GLU   B 1 174 ? 53.827 -7.604  24.707 1.00 30.51 ? 154 GLU   B HA   1 
ATOM   4834 H HB2  . GLU   B 1 174 ? 56.140 -7.728  24.331 1.00 34.23 ? 154 GLU   B HB2  1 
ATOM   4835 H HB3  . GLU   B 1 174 ? 55.896 -7.411  22.793 1.00 34.23 ? 154 GLU   B HB3  1 
ATOM   4836 H HG2  . GLU   B 1 174 ? 55.528 -5.286  23.163 1.00 47.42 ? 154 GLU   B HG2  1 
ATOM   4837 H HG3  . GLU   B 1 174 ? 55.042 -5.535  24.656 1.00 47.42 ? 154 GLU   B HG3  1 
ATOM   4838 N N    . VAL   B 1 175 ? 52.488 -6.114  23.300 1.00 19.33 ? 155 VAL   B N    1 
ATOM   4839 C CA   . VAL   B 1 175 ? 51.569 -5.352  22.461 1.00 19.91 ? 155 VAL   B CA   1 
ATOM   4840 C C    . VAL   B 1 175 ? 52.101 -3.919  22.363 1.00 17.53 ? 155 VAL   B C    1 
ATOM   4841 O O    . VAL   B 1 175 ? 52.302 -3.274  23.396 1.00 20.17 ? 155 VAL   B O    1 
ATOM   4842 C CB   . VAL   B 1 175 ? 50.139 -5.376  23.014 1.00 19.25 ? 155 VAL   B CB   1 
ATOM   4843 C CG1  . VAL   B 1 175 ? 49.209 -4.559  22.130 1.00 20.88 ? 155 VAL   B CG1  1 
ATOM   4844 C CG2  . VAL   B 1 175 ? 49.650 -6.823  23.124 1.00 21.38 ? 155 VAL   B CG2  1 
ATOM   4845 H H    . VAL   B 1 175 ? 52.490 -5.871  24.125 1.00 23.20 ? 155 VAL   B H    1 
ATOM   4846 H HA   . VAL   B 1 175 ? 51.555 -5.735  21.570 1.00 23.90 ? 155 VAL   B HA   1 
ATOM   4847 H HB   . VAL   B 1 175 ? 50.130 -4.978  23.898 1.00 23.11 ? 155 VAL   B HB   1 
ATOM   4848 H HG11 . VAL   B 1 175 ? 48.292 -4.718  22.404 1.00 25.06 ? 155 VAL   B HG11 1 
ATOM   4849 H HG12 . VAL   B 1 175 ? 49.425 -3.618  22.228 1.00 25.06 ? 155 VAL   B HG12 1 
ATOM   4850 H HG13 . VAL   B 1 175 ? 49.330 -4.831  21.207 1.00 25.06 ? 155 VAL   B HG13 1 
ATOM   4851 H HG21 . VAL   B 1 175 ? 48.756 -6.826  23.500 1.00 25.66 ? 155 VAL   B HG21 1 
ATOM   4852 H HG22 . VAL   B 1 175 ? 49.639 -7.221  22.240 1.00 25.66 ? 155 VAL   B HG22 1 
ATOM   4853 H HG23 . VAL   B 1 175 ? 50.253 -7.316  23.702 1.00 25.66 ? 155 VAL   B HG23 1 
ATOM   4854 N N    . PRO   B 1 176 ? 52.358 -3.411  21.162 1.00 18.87 ? 156 PRO   B N    1 
ATOM   4855 C CA   . PRO   B 1 176 ? 52.834 -2.029  21.044 1.00 22.06 ? 156 PRO   B CA   1 
ATOM   4856 C C    . PRO   B 1 176 ? 51.735 -1.040  21.395 1.00 21.71 ? 156 PRO   B C    1 
ATOM   4857 O O    . PRO   B 1 176 ? 50.541 -1.332  21.313 1.00 22.47 ? 156 PRO   B O    1 
ATOM   4858 C CB   . PRO   B 1 176 ? 53.243 -1.915  19.574 1.00 28.11 ? 156 PRO   B CB   1 
ATOM   4859 C CG   . PRO   B 1 176 ? 52.345 -2.890  18.874 1.00 26.14 ? 156 PRO   B CG   1 
ATOM   4860 C CD   . PRO   B 1 176 ? 52.156 -4.035  19.844 1.00 20.01 ? 156 PRO   B CD   1 
ATOM   4861 H HA   . PRO   B 1 176 ? 53.608 -1.874  21.606 1.00 26.49 ? 156 PRO   B HA   1 
ATOM   4862 H HB2  . PRO   B 1 176 ? 53.096 -1.011  19.255 1.00 33.75 ? 156 PRO   B HB2  1 
ATOM   4863 H HB3  . PRO   B 1 176 ? 54.176 -2.157  19.467 1.00 33.75 ? 156 PRO   B HB3  1 
ATOM   4864 H HG2  . PRO   B 1 176 ? 51.496 -2.467  18.669 1.00 31.38 ? 156 PRO   B HG2  1 
ATOM   4865 H HG3  . PRO   B 1 176 ? 52.768 -3.197  18.056 1.00 31.38 ? 156 PRO   B HG3  1 
ATOM   4866 H HD2  . PRO   B 1 176 ? 51.261 -4.403  19.772 1.00 24.03 ? 156 PRO   B HD2  1 
ATOM   4867 H HD3  . PRO   B 1 176 ? 52.814 -4.730  19.688 1.00 24.03 ? 156 PRO   B HD3  1 
ATOM   4868 N N    . GLU   B 1 177 ? 52.171 0.148   21.807 1.00 22.62 ? 157 GLU   B N    1 
ATOM   4869 C CA   . GLU   B 1 177 ? 51.280 1.216   22.243 1.00 21.37 ? 157 GLU   B CA   1 
ATOM   4870 C C    . GLU   B 1 177 ? 51.240 2.295   21.173 1.00 26.74 ? 157 GLU   B C    1 
ATOM   4871 O O    . GLU   B 1 177 ? 52.265 2.906   20.864 1.00 34.02 ? 157 GLU   B O    1 
ATOM   4872 C CB   . GLU   B 1 177 ? 51.741 1.807   23.573 1.00 27.83 ? 157 GLU   B CB   1 
ATOM   4873 C CG   . GLU   B 1 177 ? 51.839 0.807   24.700 1.00 42.88 ? 157 GLU   B CG   1 
ATOM   4874 C CD   . GLU   B 1 177 ? 52.447 1.416   25.946 1.00 65.85 ? 157 GLU   B CD   1 
ATOM   4875 O OE1  . GLU   B 1 177 ? 52.157 2.596   26.238 1.00 49.89 ? 157 GLU   B OE1  1 
ATOM   4876 O OE2  . GLU   B 1 177 ? 53.221 0.718   26.630 1.00 62.47 ? 157 GLU   B OE2  1 
ATOM   4877 H H    . GLU   B 1 177 ? 53.002 0.364   21.842 1.00 27.15 ? 157 GLU   B H    1 
ATOM   4878 H HA   . GLU   B 1 177 ? 50.386 0.858   22.356 1.00 25.65 ? 157 GLU   B HA   1 
ATOM   4879 H HB2  . GLU   B 1 177 ? 52.621 2.197   23.450 1.00 33.41 ? 157 GLU   B HB2  1 
ATOM   4880 H HB3  . GLU   B 1 177 ? 51.110 2.492   23.842 1.00 33.41 ? 157 GLU   B HB3  1 
ATOM   4881 H HG2  . GLU   B 1 177 ? 50.951 0.487   24.921 1.00 51.46 ? 157 GLU   B HG2  1 
ATOM   4882 H HG3  . GLU   B 1 177 ? 52.399 0.066   24.421 1.00 51.46 ? 157 GLU   B HG3  1 
ATOM   4883 N N    . VAL   B 1 178 ? 50.057 2.523   20.615 1.00 22.70 ? 158 VAL   B N    1 
ATOM   4884 C CA   . VAL   B 1 178 ? 49.851 3.589   19.644 1.00 21.61 ? 158 VAL   B CA   1 
ATOM   4885 C C    . VAL   B 1 178 ? 49.755 4.908   20.398 1.00 25.02 ? 158 VAL   B C    1 
ATOM   4886 O O    . VAL   B 1 178 ? 48.933 5.056   21.310 1.00 24.33 ? 158 VAL   B O    1 
ATOM   4887 C CB   . VAL   B 1 178 ? 48.587 3.335   18.810 1.00 22.23 ? 158 VAL   B CB   1 
ATOM   4888 C CG1  . VAL   B 1 178 ? 48.274 4.537   17.939 1.00 24.27 ? 158 VAL   B CG1  1 
ATOM   4889 C CG2  . VAL   B 1 178 ? 48.766 2.075   17.972 1.00 25.16 ? 158 VAL   B CG2  1 
ATOM   4890 H H    . VAL   B 1 178 ? 49.347 2.067   20.785 1.00 27.25 ? 158 VAL   B H    1 
ATOM   4891 H HA   . VAL   B 1 178 ? 50.610 3.632   19.042 1.00 25.95 ? 158 VAL   B HA   1 
ATOM   4892 H HB   . VAL   B 1 178 ? 47.830 3.199   19.401 1.00 26.69 ? 158 VAL   B HB   1 
ATOM   4893 H HG11 . VAL   B 1 178 ? 47.707 4.256   17.205 1.00 29.13 ? 158 VAL   B HG11 1 
ATOM   4894 H HG12 . VAL   B 1 178 ? 47.816 5.204   18.474 1.00 29.13 ? 158 VAL   B HG12 1 
ATOM   4895 H HG13 . VAL   B 1 178 ? 49.104 4.902   17.595 1.00 29.13 ? 158 VAL   B HG13 1 
ATOM   4896 H HG21 . VAL   B 1 178 ? 47.973 1.940   17.431 1.00 30.20 ? 158 VAL   B HG21 1 
ATOM   4897 H HG22 . VAL   B 1 178 ? 49.542 2.184   17.400 1.00 30.20 ? 158 VAL   B HG22 1 
ATOM   4898 H HG23 . VAL   B 1 178 ? 48.896 1.317   18.564 1.00 30.20 ? 158 VAL   B HG23 1 
ATOM   4899 N N    . ARG   B 1 179 ? 50.613 5.857   20.039 1.00 21.64 ? 159 ARG   B N    1 
ATOM   4900 C CA   . ARG   B 1 179 ? 50.556 7.196   20.609 1.00 24.34 ? 159 ARG   B CA   1 
ATOM   4901 C C    . ARG   B 1 179 ? 49.608 8.046   19.776 1.00 20.31 ? 159 ARG   B C    1 
ATOM   4902 O O    . ARG   B 1 179 ? 49.818 8.218   18.570 1.00 24.22 ? 159 ARG   B O    1 
ATOM   4903 C CB   . ARG   B 1 179 ? 51.940 7.836   20.651 1.00 23.46 ? 159 ARG   B CB   1 
ATOM   4904 C CG   . ARG   B 1 179 ? 51.925 9.232   21.251 1.00 33.21 ? 159 ARG   B CG   1 
ATOM   4905 C CD   . ARG   B 1 179 ? 53.318 9.821   21.278 1.00 44.99 ? 159 ARG   B CD   1 
ATOM   4906 N NE   . ARG   B 1 179 ? 53.376 11.054  22.052 1.00 44.05 ? 159 ARG   B NE   1 
ATOM   4907 C CZ   . ARG   B 1 179 ? 54.502 11.654  22.410 1.00 43.97 ? 159 ARG   B CZ   1 
ATOM   4908 N NH1  . ARG   B 1 179 ? 55.683 11.154  22.088 1.00 40.99 ? 159 ARG   B NH1  1 
ATOM   4909 N NH2  . ARG   B 1 179 ? 54.442 12.783  23.108 1.00 39.05 ? 159 ARG   B NH2  1 
ATOM   4910 H H    . ARG   B 1 179 ? 51.241 5.748   19.463 1.00 25.98 ? 159 ARG   B H    1 
ATOM   4911 H HA   . ARG   B 1 179 ? 50.221 7.141   21.518 1.00 29.22 ? 159 ARG   B HA   1 
ATOM   4912 H HB2  . ARG   B 1 179 ? 52.527 7.284   21.191 1.00 28.16 ? 159 ARG   B HB2  1 
ATOM   4913 H HB3  . ARG   B 1 179 ? 52.285 7.902   19.747 1.00 28.16 ? 159 ARG   B HB3  1 
ATOM   4914 H HG2  . ARG   B 1 179 ? 51.357 9.808   20.715 1.00 39.87 ? 159 ARG   B HG2  1 
ATOM   4915 H HG3  . ARG   B 1 179 ? 51.591 9.190   22.160 1.00 39.87 ? 159 ARG   B HG3  1 
ATOM   4916 H HD2  . ARG   B 1 179 ? 53.927 9.182   21.680 1.00 54.00 ? 159 ARG   B HD2  1 
ATOM   4917 H HD3  . ARG   B 1 179 ? 53.598 10.020  20.370 1.00 54.00 ? 159 ARG   B HD3  1 
ATOM   4918 H HE   . ARG   B 1 179 ? 52.633 11.415  22.292 1.00 52.87 ? 159 ARG   B HE   1 
ATOM   4919 H HH11 . ARG   B 1 179 ? 56.402 11.559  22.330 1.00 49.20 ? 159 ARG   B HH11 1 
ATOM   4920 H HH12 . ARG   B 1 179 ? 55.732 10.424  21.637 1.00 49.20 ? 159 ARG   B HH12 1 
ATOM   4921 H HH21 . ARG   B 1 179 ? 53.679 13.116  23.322 1.00 46.88 ? 159 ARG   B HH21 1 
ATOM   4922 H HH22 . ARG   B 1 179 ? 55.167 13.181  23.345 1.00 46.88 ? 159 ARG   B HH22 1 
ATOM   4923 N N    . ARG   B 1 180 ? 48.563 8.567   20.415 1.00 20.93 ? 160 ARG   B N    1 
ATOM   4924 C CA   . ARG   B 1 180 ? 47.619 9.485   19.782 1.00 20.88 ? 160 ARG   B CA   1 
ATOM   4925 C C    . ARG   B 1 180 ? 47.884 10.859  20.390 1.00 23.82 ? 160 ARG   B C    1 
ATOM   4926 O O    . ARG   B 1 180 ? 47.147 11.343  21.249 1.00 26.39 ? 160 ARG   B O    1 
ATOM   4927 C CB   . ARG   B 1 180 ? 46.186 9.010   19.985 1.00 21.94 ? 160 ARG   B CB   1 
ATOM   4928 C CG   . ARG   B 1 180 ? 45.923 7.672   19.293 1.00 25.46 ? 160 ARG   B CG   1 
ATOM   4929 C CD   . ARG   B 1 180 ? 44.515 7.152   19.539 1.00 25.74 ? 160 ARG   B CD   1 
ATOM   4930 N NE   . ARG   B 1 180 ? 44.283 5.866   18.892 1.00 22.41 ? 160 ARG   B NE   1 
ATOM   4931 C CZ   . ARG   B 1 180 ? 44.572 4.688   19.432 1.00 21.19 ? 160 ARG   B CZ   1 
ATOM   4932 N NH1  . ARG   B 1 180 ? 45.117 4.591   20.633 1.00 21.17 ? 160 ARG   B NH1  1 
ATOM   4933 N NH2  . ARG   B 1 180 ? 44.309 3.577   18.744 1.00 21.86 ? 160 ARG   B NH2  1 
ATOM   4934 H H    . ARG   B 1 180 ? 48.376 8.400   21.237 1.00 25.13 ? 160 ARG   B H    1 
ATOM   4935 H HA   . ARG   B 1 180 ? 47.771 9.529   18.825 1.00 25.06 ? 160 ARG   B HA   1 
ATOM   4936 H HB2  . ARG   B 1 180 ? 46.019 8.899   20.934 1.00 26.35 ? 160 ARG   B HB2  1 
ATOM   4937 H HB3  . ARG   B 1 180 ? 45.577 9.668   19.615 1.00 26.35 ? 160 ARG   B HB3  1 
ATOM   4938 H HG2  . ARG   B 1 180 ? 46.039 7.782   18.336 1.00 30.56 ? 160 ARG   B HG2  1 
ATOM   4939 H HG3  . ARG   B 1 180 ? 46.550 7.012   19.629 1.00 30.56 ? 160 ARG   B HG3  1 
ATOM   4940 H HD2  . ARG   B 1 180 ? 44.379 7.039   20.493 1.00 30.90 ? 160 ARG   B HD2  1 
ATOM   4941 H HD3  . ARG   B 1 180 ? 43.873 7.788   19.186 1.00 30.90 ? 160 ARG   B HD3  1 
ATOM   4942 H HE   . ARG   B 1 180 ? 43.935 5.871   18.106 1.00 26.91 ? 160 ARG   B HE   1 
ATOM   4943 H HH11 . ARG   B 1 180 ? 45.295 3.817   20.963 1.00 25.42 ? 160 ARG   B HH11 1 
ATOM   4944 H HH12 . ARG   B 1 180 ? 45.293 5.301   21.085 1.00 25.42 ? 160 ARG   B HH12 1 
ATOM   4945 H HH21 . ARG   B 1 180 ? 43.957 3.629   17.961 1.00 26.25 ? 160 ARG   B HH21 1 
ATOM   4946 H HH22 . ARG   B 1 180 ? 44.492 2.808   19.083 1.00 26.25 ? 160 ARG   B HH22 1 
ATOM   4947 N N    . ASP   B 1 181 ? 48.985 11.470  19.958 1.00 25.62 ? 161 ASP   B N    1 
ATOM   4948 C CA   . ASP   B 1 181 ? 49.394 12.753  20.511 1.00 22.46 ? 161 ASP   B CA   1 
ATOM   4949 C C    . ASP   B 1 181 ? 48.328 13.797  20.215 1.00 31.10 ? 161 ASP   B C    1 
ATOM   4950 O O    . ASP   B 1 181 ? 47.897 13.962  19.067 1.00 31.57 ? 161 ASP   B O    1 
ATOM   4951 C CB   . ASP   B 1 181 ? 50.738 13.176  19.920 1.00 24.72 ? 161 ASP   B CB   1 
ATOM   4952 C CG   . ASP   B 1 181 ? 51.452 14.204  20.771 1.00 45.64 ? 161 ASP   B CG   1 
ATOM   4953 O OD1  . ASP   B 1 181 ? 50.912 14.591  21.832 1.00 30.24 ? 161 ASP   B OD1  1 
ATOM   4954 O OD2  . ASP   B 1 181 ? 52.549 14.631  20.373 1.00 31.61 ? 161 ASP   B OD2  1 
ATOM   4955 H H    . ASP   B 1 181 ? 49.509 11.163  19.349 1.00 30.76 ? 161 ASP   B H    1 
ATOM   4956 H HA   . ASP   B 1 181 ? 49.504 12.682  21.472 1.00 26.97 ? 161 ASP   B HA   1 
ATOM   4957 H HB2  . ASP   B 1 181 ? 51.311 12.396  19.846 1.00 29.67 ? 161 ASP   B HB2  1 
ATOM   4958 H HB3  . ASP   B 1 181 ? 50.590 13.562  19.042 1.00 29.67 ? 161 ASP   B HB3  1 
ATOM   4959 N N    . GLY   B 1 182 ? 47.872 14.475  21.260 1.00 32.37 ? 162 GLY   B N    1 
ATOM   4960 C CA   . GLY   B 1 182 ? 46.858 15.493  21.107 1.00 35.39 ? 162 GLY   B CA   1 
ATOM   4961 C C    . GLY   B 1 182 ? 45.432 14.996  21.147 1.00 30.23 ? 162 GLY   B C    1 
ATOM   4962 O O    . GLY   B 1 182 ? 44.508 15.810  21.009 1.00 28.11 ? 162 GLY   B O    1 
ATOM   4963 H H    . GLY   B 1 182 ? 48.139 14.360  22.069 1.00 38.86 ? 162 GLY   B H    1 
ATOM   4964 H HA2  . GLY   B 1 182 ? 46.962 16.143  21.819 1.00 42.48 ? 162 GLY   B HA2  1 
ATOM   4965 H HA3  . GLY   B 1 182 ? 46.990 15.936  20.254 1.00 42.48 ? 162 GLY   B HA3  1 
ATOM   4966 N N    . LEU   B 1 183 ? 45.216 13.695  21.314 1.00 28.23 ? 163 LEU   B N    1 
ATOM   4967 C CA   . LEU   B 1 183 ? 43.870 13.167  21.453 1.00 29.29 ? 163 LEU   B CA   1 
ATOM   4968 C C    . LEU   B 1 183 ? 43.146 13.906  22.578 1.00 30.19 ? 163 LEU   B C    1 
ATOM   4969 O O    . LEU   B 1 183 ? 43.593 13.848  23.732 1.00 32.71 ? 163 LEU   B O    1 
ATOM   4970 C CB   . LEU   B 1 183 ? 43.917 11.672  21.742 1.00 27.27 ? 163 LEU   B CB   1 
ATOM   4971 C CG   . LEU   B 1 183 ? 42.574 10.963  21.907 1.00 31.92 ? 163 LEU   B CG   1 
ATOM   4972 C CD1  . LEU   B 1 183 ? 41.726 11.098  20.653 1.00 26.88 ? 163 LEU   B CD1  1 
ATOM   4973 C CD2  . LEU   B 1 183 ? 42.793 9.498   22.253 1.00 35.68 ? 163 LEU   B CD2  1 
ATOM   4974 H H    . LEU   B 1 183 ? 45.836 13.099  21.350 1.00 33.89 ? 163 LEU   B H    1 
ATOM   4975 H HA   . LEU   B 1 183 ? 43.378 13.293  20.626 1.00 35.17 ? 163 LEU   B HA   1 
ATOM   4976 H HB2  . LEU   B 1 183 ? 44.378 11.239  21.006 1.00 32.74 ? 163 LEU   B HB2  1 
ATOM   4977 H HB3  . LEU   B 1 183 ? 44.411 11.541  22.566 1.00 32.74 ? 163 LEU   B HB3  1 
ATOM   4978 H HG   . LEU   B 1 183 ? 42.086 11.381  22.634 1.00 38.31 ? 163 LEU   B HG   1 
ATOM   4979 H HD11 . LEU   B 1 183 ? 40.933 10.548  20.748 1.00 32.27 ? 163 LEU   B HD11 1 
ATOM   4980 H HD12 . LEU   B 1 183 ? 41.473 12.027  20.542 1.00 32.27 ? 163 LEU   B HD12 1 
ATOM   4981 H HD13 . LEU   B 1 183 ? 42.244 10.802  19.889 1.00 32.27 ? 163 LEU   B HD13 1 
ATOM   4982 H HD21 . LEU   B 1 183 ? 41.932 9.068   22.367 1.00 42.82 ? 163 LEU   B HD21 1 
ATOM   4983 H HD22 . LEU   B 1 183 ? 43.282 9.073   21.530 1.00 42.82 ? 163 LEU   B HD22 1 
ATOM   4984 H HD23 . LEU   B 1 183 ? 43.304 9.441   23.076 1.00 42.82 ? 163 LEU   B HD23 1 
ATOM   4985 N N    . PRO   B 1 184 ? 42.058 14.618  22.288 1.00 31.59 ? 164 PRO   B N    1 
ATOM   4986 C CA   . PRO   B 1 184 ? 41.387 15.378  23.347 1.00 38.52 ? 164 PRO   B CA   1 
ATOM   4987 C C    . PRO   B 1 184 ? 40.908 14.463  24.461 1.00 40.56 ? 164 PRO   B C    1 
ATOM   4988 O O    . PRO   B 1 184 ? 40.548 13.305  24.236 1.00 33.83 ? 164 PRO   B O    1 
ATOM   4989 C CB   . PRO   B 1 184 ? 40.213 16.049  22.622 1.00 36.86 ? 164 PRO   B CB   1 
ATOM   4990 C CG   . PRO   B 1 184 ? 40.636 16.091  21.168 1.00 35.03 ? 164 PRO   B CG   1 
ATOM   4991 C CD   . PRO   B 1 184 ? 41.418 14.814  20.973 1.00 38.10 ? 164 PRO   B CD   1 
ATOM   4992 H HA   . PRO   B 1 184 ? 41.973 16.059  23.712 1.00 46.23 ? 164 PRO   B HA   1 
ATOM   4993 H HB2  . PRO   B 1 184 ? 39.407 15.521  22.735 1.00 44.25 ? 164 PRO   B HB2  1 
ATOM   4994 H HB3  . PRO   B 1 184 ? 40.076 16.944  22.970 1.00 44.25 ? 164 PRO   B HB3  1 
ATOM   4995 H HG2  . PRO   B 1 184 ? 39.855 16.113  20.594 1.00 42.04 ? 164 PRO   B HG2  1 
ATOM   4996 H HG3  . PRO   B 1 184 ? 41.191 16.869  21.004 1.00 42.04 ? 164 PRO   B HG3  1 
ATOM   4997 H HD2  . PRO   B 1 184 ? 40.828 14.074  20.761 1.00 45.74 ? 164 PRO   B HD2  1 
ATOM   4998 H HD3  . PRO   B 1 184 ? 42.084 14.918  20.276 1.00 45.74 ? 164 PRO   B HD3  1 
ATOM   4999 N N    . SER   B 1 185 ? 40.919 14.997  25.679 1.00 53.98 ? 165 SER   B N    1 
ATOM   5000 C CA   . SER   B 1 185 ? 40.433 14.260  26.841 1.00 65.05 ? 165 SER   B CA   1 
ATOM   5001 C C    . SER   B 1 185 ? 39.175 14.913  27.409 1.00 55.02 ? 165 SER   B C    1 
ATOM   5002 O O    . SER   B 1 185 ? 38.808 16.036  27.053 1.00 46.54 ? 165 SER   B O    1 
ATOM   5003 C CB   . SER   B 1 185 ? 41.516 14.180  27.917 1.00 51.58 ? 165 SER   B CB   1 
ATOM   5004 O OXT  . SER   B 1 185 ? 38.491 14.329  28.245 1.00 61.71 ? 165 SER   B OXT  1 
ATOM   5005 H H    . SER   B 1 185 ? 41.203 15.789  25.859 1.00 64.79 ? 165 SER   B H    1 
ATOM   5006 H HA   . SER   B 1 185 ? 40.210 13.355  26.573 1.00 78.08 ? 165 SER   B HA   1 
HETATM 5007 C C1   . GOL   C 2 .   ? 38.174 7.898   11.541 1.00 18.47 ? 201 GOL   A C1   1 
HETATM 5008 O O1   . GOL   C 2 .   ? 36.916 8.521   11.634 1.00 26.36 ? 201 GOL   A O1   1 
HETATM 5009 C C2   . GOL   C 2 .   ? 38.279 6.957   12.759 1.00 36.39 ? 201 GOL   A C2   1 
HETATM 5010 O O2   . GOL   C 2 .   ? 37.035 6.781   13.343 1.00 37.69 ? 201 GOL   A O2   1 
HETATM 5011 C C3   . GOL   C 2 .   ? 38.870 5.669   12.204 1.00 25.11 ? 201 GOL   A C3   1 
HETATM 5012 O O3   . GOL   C 2 .   ? 38.343 4.622   12.968 1.00 25.48 ? 201 GOL   A O3   1 
HETATM 5013 H H11  . GOL   C 2 .   ? 38.909 8.532   11.556 1.00 22.18 ? 201 GOL   A H11  1 
HETATM 5014 H H12  . GOL   C 2 .   ? 38.281 7.386   10.724 1.00 22.18 ? 201 GOL   A H12  1 
HETATM 5015 H HO1  . GOL   C 2 .   ? 37.042 9.268   12.025 1.00 31.64 ? 201 GOL   A HO1  1 
HETATM 5016 H H2   . GOL   C 2 .   ? 38.858 7.316   13.449 1.00 43.68 ? 201 GOL   A H2   1 
HETATM 5017 H HO2  . GOL   C 2 .   ? 37.116 6.224   13.967 1.00 45.25 ? 201 GOL   A HO2  1 
HETATM 5018 H H31  . GOL   C 2 .   ? 39.838 5.725   12.242 1.00 30.14 ? 201 GOL   A H31  1 
HETATM 5019 H H32  . GOL   C 2 .   ? 38.654 5.604   11.261 1.00 30.14 ? 201 GOL   A H32  1 
HETATM 5020 H HO3  . GOL   C 2 .   ? 37.586 4.433   12.644 1.00 30.59 ? 201 GOL   A HO3  1 
HETATM 5021 C C1   . GOL   D 2 .   ? 40.348 -3.584  5.572  1.00 46.74 ? 202 GOL   A C1   1 
HETATM 5022 O O1   . GOL   D 2 .   ? 40.010 -3.935  4.240  1.00 66.86 ? 202 GOL   A O1   1 
HETATM 5023 C C2   . GOL   D 2 .   ? 41.508 -4.511  5.997  1.00 46.40 ? 202 GOL   A C2   1 
HETATM 5024 O O2   . GOL   D 2 .   ? 42.725 -3.841  6.129  1.00 47.17 ? 202 GOL   A O2   1 
HETATM 5025 C C3   . GOL   D 2 .   ? 41.017 -5.119  7.328  1.00 42.78 ? 202 GOL   A C3   1 
HETATM 5026 O O3   . GOL   D 2 .   ? 41.611 -6.391  7.464  1.00 52.41 ? 202 GOL   A O3   1 
HETATM 5027 H H11  . GOL   D 2 .   ? 39.607 -3.693  6.187  1.00 56.10 ? 202 GOL   A H11  1 
HETATM 5028 H H12  . GOL   D 2 .   ? 40.629 -2.659  5.654  1.00 56.10 ? 202 GOL   A H12  1 
HETATM 5029 H HO1  . GOL   D 2 .   ? 39.354 -3.442  4.003  1.00 80.24 ? 202 GOL   A HO1  1 
HETATM 5030 H H2   . GOL   D 2 .   ? 41.673 -5.190  5.325  1.00 55.70 ? 202 GOL   A H2   1 
HETATM 5031 H HO2  . GOL   D 2 .   ? 42.718 -3.386  6.852  1.00 56.62 ? 202 GOL   A HO2  1 
HETATM 5032 H H31  . GOL   D 2 .   ? 40.047 -5.149  7.316  1.00 51.35 ? 202 GOL   A H31  1 
HETATM 5033 H H32  . GOL   D 2 .   ? 41.245 -4.512  8.049  1.00 51.35 ? 202 GOL   A H32  1 
HETATM 5034 H HO3  . GOL   D 2 .   ? 42.452 -6.286  7.539  1.00 62.90 ? 202 GOL   A HO3  1 
HETATM 5035 C C1   . GOL   E 2 .   ? 14.495 -6.197  12.011 1.00 46.77 ? 203 GOL   A C1   1 
HETATM 5036 O O1   . GOL   E 2 .   ? 13.811 -5.228  11.235 1.00 50.09 ? 203 GOL   A O1   1 
HETATM 5037 C C2   . GOL   E 2 .   ? 13.441 -7.031  12.750 1.00 41.49 ? 203 GOL   A C2   1 
HETATM 5038 O O2   . GOL   E 2 .   ? 12.533 -7.634  11.886 1.00 57.61 ? 203 GOL   A O2   1 
HETATM 5039 C C3   . GOL   E 2 .   ? 14.248 -8.095  13.533 1.00 41.15 ? 203 GOL   A C3   1 
HETATM 5040 O O3   . GOL   E 2 .   ? 13.331 -8.875  14.267 1.00 48.41 ? 203 GOL   A O3   1 
HETATM 5041 H H11  . GOL   E 2 .   ? 15.095 -5.797  12.659 1.00 56.14 ? 203 GOL   A H11  1 
HETATM 5042 H H12  . GOL   E 2 .   ? 15.043 -6.786  11.469 1.00 56.14 ? 203 GOL   A H12  1 
HETATM 5043 H HO1  . GOL   E 2 .   ? 14.248 -4.486  11.310 1.00 60.12 ? 203 GOL   A HO1  1 
HETATM 5044 H H2   . GOL   E 2 .   ? 12.925 -6.458  13.339 1.00 49.80 ? 203 GOL   A H2   1 
HETATM 5045 H HO2  . GOL   E 2 .   ? 12.956 -8.220  11.422 1.00 69.15 ? 203 GOL   A HO2  1 
HETATM 5046 H H31  . GOL   E 2 .   ? 14.897 -7.642  14.093 1.00 49.40 ? 203 GOL   A H31  1 
HETATM 5047 H H32  . GOL   E 2 .   ? 14.771 -8.614  12.902 1.00 49.40 ? 203 GOL   A H32  1 
HETATM 5048 H HO3  . GOL   E 2 .   ? 13.350 -8.572  15.073 1.00 58.10 ? 203 GOL   A HO3  1 
HETATM 5049 C C    . ACT   F 3 .   ? 41.484 5.901   16.599 1.00 29.18 ? 201 ACT   B C    1 
HETATM 5050 O O    . ACT   F 3 .   ? 40.701 6.344   17.487 1.00 36.37 ? 201 ACT   B O    1 
HETATM 5051 O OXT  . ACT   F 3 .   ? 42.721 5.708   16.649 1.00 19.70 ? 201 ACT   B OXT  1 
HETATM 5052 C CH3  . ACT   F 3 .   ? 40.841 5.581   15.273 1.00 34.80 ? 201 ACT   B CH3  1 
HETATM 5053 H H1   . ACT   F 3 .   ? 41.515 5.248   14.660 1.00 41.78 ? 201 ACT   B H1   1 
HETATM 5054 H H2   . ACT   F 3 .   ? 40.157 4.906   15.401 1.00 41.78 ? 201 ACT   B H2   1 
HETATM 5055 H H3   . ACT   F 3 .   ? 40.439 6.384   14.907 1.00 41.78 ? 201 ACT   B H3   1 
HETATM 5056 C C1   . GOL   G 2 .   ? 37.258 -20.118 21.673 1.00 20.18 ? 202 GOL   B C1   1 
HETATM 5057 O O1   . GOL   G 2 .   ? 36.767 -21.382 21.320 1.00 27.94 ? 202 GOL   B O1   1 
HETATM 5058 C C2   . GOL   G 2 .   ? 37.552 -19.372 20.361 1.00 26.43 ? 202 GOL   B C2   1 
HETATM 5059 O O2   . GOL   G 2 .   ? 36.449 -19.333 19.522 1.00 23.73 ? 202 GOL   B O2   1 
HETATM 5060 C C3   . GOL   G 2 .   ? 38.010 -17.976 20.801 1.00 21.54 ? 202 GOL   B C3   1 
HETATM 5061 O O3   . GOL   G 2 .   ? 38.308 -17.230 19.637 1.00 28.74 ? 202 GOL   B O3   1 
HETATM 5062 H H11  . GOL   G 2 .   ? 38.069 -20.167 22.203 1.00 24.23 ? 202 GOL   B H11  1 
HETATM 5063 H H12  . GOL   G 2 .   ? 36.626 -19.605 22.200 1.00 24.23 ? 202 GOL   B H12  1 
HETATM 5064 H HO1  . GOL   G 2 .   ? 35.941 -21.295 21.147 1.00 33.54 ? 202 GOL   B HO1  1 
HETATM 5065 H H2   . GOL   G 2 .   ? 38.246 -19.823 19.857 1.00 31.73 ? 202 GOL   B H2   1 
HETATM 5066 H HO2  . GOL   G 2 .   ? 36.735 -19.395 18.725 1.00 28.49 ? 202 GOL   B HO2  1 
HETATM 5067 H H31  . GOL   G 2 .   ? 38.770 -18.074 21.397 1.00 25.86 ? 202 GOL   B H31  1 
HETATM 5068 H H32  . GOL   G 2 .   ? 37.311 -17.577 21.341 1.00 25.86 ? 202 GOL   B H32  1 
HETATM 5069 H HO3  . GOL   G 2 .   ? 37.761 -17.467 19.027 1.00 34.50 ? 202 GOL   B HO3  1 
HETATM 5070 C C1   . A1IAH H 4 .   ? 39.024 -20.688 12.932 1.00 22.70 ? 203 A1IAH B C1   1 
HETATM 5071 C C2   . A1IAH H 4 .   ? 40.490 -20.500 13.269 1.00 22.63 ? 203 A1IAH B C2   1 
HETATM 5072 C C3   . A1IAH H 4 .   ? 41.322 -21.711 12.840 1.00 26.74 ? 203 A1IAH B C3   1 
HETATM 5073 C C4   . A1IAH H 4 .   ? 40.693 -20.230 14.751 1.00 22.74 ? 203 A1IAH B C4   1 
HETATM 5074 C C5   . A1IAH H 4 .   ? 39.771 -20.674 15.688 1.00 28.06 ? 203 A1IAH B C5   1 
HETATM 5075 C C6   . A1IAH H 4 .   ? 39.963 -20.430 17.036 1.00 39.38 ? 203 A1IAH B C6   1 
HETATM 5076 C C7   . A1IAH H 4 .   ? 41.083 -19.743 17.464 1.00 30.20 ? 203 A1IAH B C7   1 
HETATM 5077 C C8   . A1IAH H 4 .   ? 42.027 -19.298 16.549 1.00 21.37 ? 203 A1IAH B C8   1 
HETATM 5078 C C9   . A1IAH H 4 .   ? 43.226 -18.564 17.032 1.00 18.93 ? 203 A1IAH B C9   1 
HETATM 5079 C C10  . A1IAH H 4 .   ? 44.361 -18.249 16.144 1.00 21.47 ? 203 A1IAH B C10  1 
HETATM 5080 C C11  . A1IAH H 4 .   ? 45.097 -19.073 15.241 1.00 19.74 ? 203 A1IAH B C11  1 
HETATM 5081 C C12  . A1IAH H 4 .   ? 44.924 -20.468 14.823 1.00 20.73 ? 203 A1IAH B C12  1 
HETATM 5082 C C13  . A1IAH H 4 .   ? 45.276 -20.855 13.532 1.00 28.32 ? 203 A1IAH B C13  1 
HETATM 5083 C C14  . A1IAH H 4 .   ? 45.119 -22.166 13.118 1.00 25.14 ? 203 A1IAH B C14  1 
HETATM 5084 C C15  . A1IAH H 4 .   ? 44.609 -23.110 13.995 1.00 21.38 ? 203 A1IAH B C15  1 
HETATM 5085 C C16  . A1IAH H 4 .   ? 44.261 -22.741 15.286 1.00 19.99 ? 203 A1IAH B C16  1 
HETATM 5086 C C17  . A1IAH H 4 .   ? 44.418 -21.427 15.696 1.00 24.48 ? 203 A1IAH B C17  1 
HETATM 5087 C C18  . A1IAH H 4 .   ? 45.978 -16.725 15.330 1.00 19.70 ? 203 A1IAH B C18  1 
HETATM 5088 C C19  . A1IAH H 4 .   ? 46.631 -15.506 15.193 1.00 19.00 ? 203 A1IAH B C19  1 
HETATM 5089 C C20  . A1IAH H 4 .   ? 46.154 -14.423 15.925 1.00 19.50 ? 203 A1IAH B C20  1 
HETATM 5090 C C21  . A1IAH H 4 .   ? 45.060 -14.554 16.775 1.00 18.05 ? 203 A1IAH B C21  1 
HETATM 5091 C C22  . A1IAH H 4 .   ? 44.409 -15.765 16.909 1.00 20.03 ? 203 A1IAH B C22  1 
HETATM 5092 C C23  . A1IAH H 4 .   ? 44.875 -16.860 16.181 1.00 21.21 ? 203 A1IAH B C23  1 
HETATM 5093 C C24  . A1IAH H 4 .   ? 41.813 -19.542 15.196 1.00 20.86 ? 203 A1IAH B C24  1 
HETATM 5094 O O1   . A1IAH H 4 .   ? 43.280 -18.194 18.206 1.00 23.61 ? 203 A1IAH B O1   1 
HETATM 5095 O O2   . A1IAH H 4 .   ? 44.454 -24.409 13.607 1.00 27.60 ? 203 A1IAH B O2   1 
HETATM 5096 O O3   . A1IAH H 4 .   ? 46.789 -13.217 15.811 1.00 20.37 ? 203 A1IAH B O3   1 
HETATM 5097 S S1   . A1IAH H 4 .   ? 46.389 -18.202 14.507 1.00 22.70 ? 203 A1IAH B S1   1 
HETATM 5098 H H1   . A1IAH H 4 .   ? 38.900 -20.620 11.971 1.00 27.26 ? 203 A1IAH B H1   1 
HETATM 5099 H H2   . A1IAH H 4 .   ? 38.498 -20.001 13.375 1.00 27.26 ? 203 A1IAH B H2   1 
HETATM 5100 H H3   . A1IAH H 4 .   ? 38.730 -21.564 13.235 1.00 27.26 ? 203 A1IAH B H3   1 
HETATM 5101 H H4   . A1IAH H 4 .   ? 40.799 -19.712 12.750 1.00 27.17 ? 203 A1IAH B H4   1 
HETATM 5102 H H7   . A1IAH H 4 .   ? 40.988 -22.508 13.284 1.00 32.10 ? 203 A1IAH B H7   1 
HETATM 5103 H H6   . A1IAH H 4 .   ? 42.252 -21.569 13.085 1.00 32.10 ? 203 A1IAH B H6   1 
HETATM 5104 H H5   . A1IAH H 4 .   ? 41.255 -21.825 11.877 1.00 32.10 ? 203 A1IAH B H5   1 
HETATM 5105 H H8   . A1IAH H 4 .   ? 39.006 -21.148 15.401 1.00 33.68 ? 203 A1IAH B H8   1 
HETATM 5106 H H9   . A1IAH H 4 .   ? 39.327 -20.734 17.665 1.00 47.27 ? 203 A1IAH B H9   1 
HETATM 5107 H H10  . A1IAH H 4 .   ? 41.206 -19.577 18.383 1.00 36.25 ? 203 A1IAH B H10  1 
HETATM 5108 H H11  . A1IAH H 4 .   ? 45.626 -20.216 12.928 1.00 34.00 ? 203 A1IAH B H11  1 
HETATM 5109 H H12  . A1IAH H 4 .   ? 45.358 -22.417 12.243 1.00 30.18 ? 203 A1IAH B H12  1 
HETATM 5110 H H14  . A1IAH H 4 .   ? 43.918 -23.383 15.882 1.00 24.00 ? 203 A1IAH B H14  1 
HETATM 5111 H H15  . A1IAH H 4 .   ? 44.177 -21.182 16.577 1.00 29.38 ? 203 A1IAH B H15  1 
HETATM 5112 H H16  . A1IAH H 4 .   ? 47.381 -15.417 14.617 1.00 22.82 ? 203 A1IAH B H16  1 
HETATM 5113 H H18  . A1IAH H 4 .   ? 44.763 -13.807 17.263 1.00 21.67 ? 203 A1IAH B H18  1 
HETATM 5114 H H19  . A1IAH H 4 .   ? 43.665 -15.849 17.481 1.00 24.05 ? 203 A1IAH B H19  1 
HETATM 5115 H H20  . A1IAH H 4 .   ? 42.438 -19.237 14.557 1.00 25.04 ? 203 A1IAH B H20  1 
HETATM 5116 H H13  . A1IAH H 4 .   ? 45.204 -24.823 13.661 1.00 33.13 ? 203 A1IAH B H13  1 
HETATM 5117 H H17  . A1IAH H 4 .   ? 47.609 -13.307 16.046 1.00 24.46 ? 203 A1IAH B H17  1 
HETATM 5118 O O    . HOH   I 5 .   ? 20.455 17.194  28.720 1.00 48.61 ? 301 HOH   A O    1 
HETATM 5119 O O    . HOH   I 5 .   ? 35.525 23.564  8.084  1.00 49.37 ? 302 HOH   A O    1 
HETATM 5120 O O    . HOH   I 5 .   ? 44.395 8.807   1.438  1.00 34.22 ? 303 HOH   A O    1 
HETATM 5121 O O    . HOH   I 5 .   ? 9.997  -3.957  16.454 1.00 49.83 ? 304 HOH   A O    1 
HETATM 5122 O O    . HOH   I 5 .   ? 46.751 15.588  5.992  1.00 41.16 ? 305 HOH   A O    1 
HETATM 5123 O O    . HOH   I 5 .   ? 13.990 0.824   8.680  1.00 44.16 ? 306 HOH   A O    1 
HETATM 5124 O O    . HOH   I 5 .   ? 56.878 -19.436 13.124 1.00 42.96 ? 307 HOH   A O    1 
HETATM 5125 O O    . HOH   I 5 .   ? 38.197 0.030   2.056  1.00 35.29 ? 308 HOH   A O    1 
HETATM 5126 O O    . HOH   I 5 .   ? 20.997 17.631  16.788 1.00 28.14 ? 309 HOH   A O    1 
HETATM 5127 O O    . HOH   I 5 .   ? 45.466 1.150   19.754 1.00 22.86 ? 310 HOH   A O    1 
HETATM 5128 O O    . HOH   I 5 .   ? 49.783 -15.713 13.215 1.00 28.16 ? 311 HOH   A O    1 
HETATM 5129 O O    . HOH   I 5 .   ? 48.237 -28.367 17.793 1.00 37.32 ? 312 HOH   A O    1 
HETATM 5130 O O    . HOH   I 5 .   ? 28.218 12.364  2.346  1.00 37.84 ? 313 HOH   A O    1 
HETATM 5131 O O    . HOH   I 5 .   ? 28.428 -0.333  26.483 1.00 37.79 ? 314 HOH   A O    1 
HETATM 5132 O O    . HOH   I 5 .   ? 31.473 7.591   -1.914 1.00 27.12 ? 315 HOH   A O    1 
HETATM 5133 O O    . HOH   I 5 .   ? 35.076 8.432   13.443 1.00 31.82 ? 316 HOH   A O    1 
HETATM 5134 O O    . HOH   I 5 .   ? 31.721 14.215  29.642 1.00 39.63 ? 317 HOH   A O    1 
HETATM 5135 O O    . HOH   I 5 .   ? 14.554 -0.089  22.657 1.00 29.60 ? 318 HOH   A O    1 
HETATM 5136 O O    . HOH   I 5 .   ? 38.023 3.409   28.796 1.00 42.16 ? 319 HOH   A O    1 
HETATM 5137 O O    . HOH   I 5 .   ? 33.063 6.746   13.939 1.00 25.34 ? 320 HOH   A O    1 
HETATM 5138 O O    . HOH   I 5 .   ? 58.685 -22.750 11.026 1.00 35.72 ? 321 HOH   A O    1 
HETATM 5139 O O    . HOH   I 5 .   ? 43.294 2.953   25.160 1.00 45.76 ? 322 HOH   A O    1 
HETATM 5140 O O    . HOH   I 5 .   ? 41.987 5.614   0.608  1.00 37.78 ? 323 HOH   A O    1 
HETATM 5141 O O    . HOH   I 5 .   ? 46.632 -6.383  5.993  1.00 40.22 ? 324 HOH   A O    1 
HETATM 5142 O O    . HOH   I 5 .   ? 45.671 16.119  8.281  1.00 31.24 ? 325 HOH   A O    1 
HETATM 5143 O O    . HOH   I 5 .   ? 25.209 8.322   28.087 1.00 48.00 ? 326 HOH   A O    1 
HETATM 5144 O O    . HOH   I 5 .   ? 48.021 8.200   2.751  1.00 43.80 ? 327 HOH   A O    1 
HETATM 5145 O O    . HOH   I 5 .   ? 20.484 -2.434  5.239  1.00 43.45 ? 328 HOH   A O    1 
HETATM 5146 O O    . HOH   I 5 .   ? 40.483 3.123   13.854 1.00 18.72 ? 329 HOH   A O    1 
HETATM 5147 O O    . HOH   I 5 .   ? 19.678 14.656  10.775 1.00 40.11 ? 330 HOH   A O    1 
HETATM 5148 O O    . HOH   I 5 .   ? 42.231 17.731  8.169  1.00 28.81 ? 331 HOH   A O    1 
HETATM 5149 O O    . HOH   I 5 .   ? 26.487 1.029   21.046 1.00 13.21 ? 332 HOH   A O    1 
HETATM 5150 O O    . HOH   I 5 .   ? 54.760 8.064   4.501  1.00 38.79 ? 333 HOH   A O    1 
HETATM 5151 O O    . HOH   I 5 .   ? 26.204 14.500  8.632  1.00 27.98 ? 334 HOH   A O    1 
HETATM 5152 O O    . HOH   I 5 .   ? 53.631 -1.392  8.250  1.00 41.73 ? 335 HOH   A O    1 
HETATM 5153 O O    . HOH   I 5 .   ? 56.125 -9.159  15.241 1.00 40.35 ? 336 HOH   A O    1 
HETATM 5154 O O    . HOH   I 5 .   ? 37.563 -6.155  12.076 1.00 27.78 ? 337 HOH   A O    1 
HETATM 5155 O O    . HOH   I 5 .   ? 41.651 9.622   6.604  1.00 16.50 ? 338 HOH   A O    1 
HETATM 5156 O O    . HOH   I 5 .   ? 54.068 3.126   18.807 1.00 36.42 ? 339 HOH   A O    1 
HETATM 5157 O O    . HOH   I 5 .   ? 31.282 9.000   17.137 1.00 25.03 ? 340 HOH   A O    1 
HETATM 5158 O O    . HOH   I 5 .   ? 55.142 -4.739  18.237 1.00 44.02 ? 341 HOH   A O    1 
HETATM 5159 O O    . HOH   I 5 .   ? 52.992 5.197   8.630  1.00 22.57 ? 342 HOH   A O    1 
HETATM 5160 O O    . HOH   I 5 .   ? 42.744 1.668   -1.135 1.00 22.53 ? 343 HOH   A O    1 
HETATM 5161 O O    . HOH   I 5 .   ? 30.569 21.144  9.731  1.00 41.90 ? 344 HOH   A O    1 
HETATM 5162 O O    . HOH   I 5 .   ? 19.010 2.326   23.468 1.00 31.41 ? 345 HOH   A O    1 
HETATM 5163 O O    . HOH   I 5 .   ? 38.487 -8.472  7.163  1.00 47.09 ? 346 HOH   A O    1 
HETATM 5164 O O    . HOH   I 5 .   ? 31.240 16.143  15.589 1.00 21.33 ? 347 HOH   A O    1 
HETATM 5165 O O    . HOH   I 5 .   ? 50.771 9.035   10.624 1.00 25.41 ? 348 HOH   A O    1 
HETATM 5166 O O    . HOH   I 5 .   ? 52.555 -22.337 17.593 1.00 24.72 ? 349 HOH   A O    1 
HETATM 5167 O O    . HOH   I 5 .   ? 31.148 9.315   9.493  1.00 16.97 ? 350 HOH   A O    1 
HETATM 5168 O O    . HOH   I 5 .   ? 4.513  3.156   12.917 1.00 46.33 ? 351 HOH   A O    1 
HETATM 5169 O O    . HOH   I 5 .   ? 30.363 -4.775  4.814  1.00 28.46 ? 352 HOH   A O    1 
HETATM 5170 O O    . HOH   I 5 .   ? 47.414 16.402  17.411 1.00 41.28 ? 353 HOH   A O    1 
HETATM 5171 O O    . HOH   I 5 .   ? 55.034 11.306  6.574  1.00 28.52 ? 354 HOH   A O    1 
HETATM 5172 O O    . HOH   I 5 .   ? 40.102 -1.956  2.358  1.00 47.38 ? 355 HOH   A O    1 
HETATM 5173 O O    . HOH   I 5 .   ? 34.770 9.505   10.256 1.00 23.43 ? 356 HOH   A O    1 
HETATM 5174 O O    . HOH   I 5 .   ? 25.786 -1.155  25.165 1.00 26.09 ? 357 HOH   A O    1 
HETATM 5175 O O    . HOH   I 5 .   ? 45.551 0.176   17.103 1.00 23.36 ? 358 HOH   A O    1 
HETATM 5176 O O    . HOH   I 5 .   ? 39.564 19.575  7.000  1.00 48.76 ? 359 HOH   A O    1 
HETATM 5177 O O    . HOH   I 5 .   ? 16.344 4.041   24.233 1.00 35.90 ? 360 HOH   A O    1 
HETATM 5178 O O    . HOH   I 5 .   ? 27.162 16.525  9.991  1.00 26.68 ? 361 HOH   A O    1 
HETATM 5179 O O    . HOH   I 5 .   ? 14.319 4.583   7.345  1.00 35.02 ? 362 HOH   A O    1 
HETATM 5180 O O    . HOH   I 5 .   ? 58.234 8.323   12.525 1.00 31.91 ? 363 HOH   A O    1 
HETATM 5181 O O    . HOH   I 5 .   ? 36.226 12.596  5.403  1.00 19.72 ? 364 HOH   A O    1 
HETATM 5182 O O    . HOH   I 5 .   ? 56.508 3.620   12.922 1.00 37.15 ? 365 HOH   A O    1 
HETATM 5183 O O    . HOH   I 5 .   ? 33.402 19.897  16.077 1.00 25.60 ? 366 HOH   A O    1 
HETATM 5184 O O    . HOH   I 5 .   ? 40.383 17.152  5.911  1.00 39.27 ? 367 HOH   A O    1 
HETATM 5185 O O    . HOH   I 5 .   ? 34.201 6.907   17.026 1.00 33.96 ? 368 HOH   A O    1 
HETATM 5186 O O    . HOH   I 5 .   ? 38.395 9.540   14.804 1.00 28.50 ? 369 HOH   A O    1 
HETATM 5187 O O    . HOH   I 5 .   ? 13.877 6.151   22.942 1.00 38.69 ? 370 HOH   A O    1 
HETATM 5188 O O    . HOH   I 5 .   ? 54.468 12.819  12.087 1.00 25.20 ? 371 HOH   A O    1 
HETATM 5189 O O    . HOH   I 5 .   ? 14.811 6.569   19.145 1.00 34.50 ? 372 HOH   A O    1 
HETATM 5190 O O    . HOH   I 5 .   ? 37.049 14.593  23.269 1.00 31.18 ? 373 HOH   A O    1 
HETATM 5191 O O    . HOH   I 5 .   ? 49.444 -1.771  24.560 1.00 38.72 ? 374 HOH   A O    1 
HETATM 5192 O O    . HOH   I 5 .   ? 19.522 18.017  19.029 1.00 26.25 ? 375 HOH   A O    1 
HETATM 5193 O O    . HOH   I 5 .   ? 47.682 10.582  1.811  1.00 38.26 ? 376 HOH   A O    1 
HETATM 5194 O O    . HOH   I 5 .   ? 8.562  5.520   18.990 1.00 41.26 ? 377 HOH   A O    1 
HETATM 5195 O O    . HOH   I 5 .   ? 35.056 11.916  12.121 1.00 21.48 ? 378 HOH   A O    1 
HETATM 5196 O O    . HOH   I 5 .   ? 9.653  7.721   12.265 1.00 36.49 ? 379 HOH   A O    1 
HETATM 5197 O O    . HOH   I 5 .   ? 53.789 -3.096  10.362 1.00 35.21 ? 380 HOH   A O    1 
HETATM 5198 O O    . HOH   I 5 .   ? 41.966 12.332  -0.258 1.00 40.26 ? 381 HOH   A O    1 
HETATM 5199 O O    . HOH   I 5 .   ? 33.266 13.356  13.565 1.00 24.96 ? 382 HOH   A O    1 
HETATM 5200 O O    . HOH   I 5 .   ? 16.633 -1.799  14.807 1.00 17.00 ? 383 HOH   A O    1 
HETATM 5201 O O    . HOH   I 5 .   ? 40.623 19.625  12.380 1.00 33.76 ? 384 HOH   A O    1 
HETATM 5202 O O    . HOH   I 5 .   ? 10.787 -6.400  18.154 1.00 52.50 ? 385 HOH   A O    1 
HETATM 5203 O O    . HOH   I 5 .   ? 43.429 20.337  14.182 1.00 37.81 ? 386 HOH   A O    1 
HETATM 5204 O O    . HOH   I 5 .   ? 27.955 4.227   26.962 1.00 34.54 ? 387 HOH   A O    1 
HETATM 5205 O O    . HOH   I 5 .   ? 19.328 -0.131  22.668 1.00 32.15 ? 388 HOH   A O    1 
HETATM 5206 O O    . HOH   I 5 .   ? 28.357 10.927  28.491 1.00 35.22 ? 389 HOH   A O    1 
HETATM 5207 O O    . HOH   I 5 .   ? 36.128 -4.554  22.546 1.00 38.10 ? 390 HOH   A O    1 
HETATM 5208 O O    . HOH   I 5 .   ? 13.346 10.704  10.412 1.00 35.92 ? 391 HOH   A O    1 
HETATM 5209 O O    . HOH   I 5 .   ? 46.650 -2.542  29.011 1.00 46.05 ? 392 HOH   A O    1 
HETATM 5210 O O    . HOH   I 5 .   ? 53.185 -26.256 11.043 1.00 44.05 ? 393 HOH   A O    1 
HETATM 5211 O O    . HOH   I 5 .   ? 58.210 9.028   16.858 1.00 47.18 ? 394 HOH   A O    1 
HETATM 5212 O O    . HOH   I 5 .   ? 17.888 -4.792  23.358 1.00 36.17 ? 395 HOH   A O    1 
HETATM 5213 O O    . HOH   I 5 .   ? 19.890 9.387   6.073  1.00 34.61 ? 396 HOH   A O    1 
HETATM 5214 O O    . HOH   I 5 .   ? 51.788 11.618  10.087 1.00 29.01 ? 397 HOH   A O    1 
HETATM 5215 O O    . HOH   I 5 .   ? 25.108 16.605  11.754 1.00 44.85 ? 398 HOH   A O    1 
HETATM 5216 O O    . HOH   I 5 .   ? 22.722 -1.337  4.304  1.00 27.76 ? 399 HOH   A O    1 
HETATM 5217 O O    . HOH   I 5 .   ? 25.594 5.843   26.480 1.00 27.36 ? 400 HOH   A O    1 
HETATM 5218 O O    . HOH   I 5 .   ? 34.210 10.112  7.447  1.00 21.18 ? 401 HOH   A O    1 
HETATM 5219 O O    . HOH   I 5 .   ? 21.187 13.723  27.185 1.00 40.43 ? 402 HOH   A O    1 
HETATM 5220 O O    . HOH   I 5 .   ? 39.938 -2.334  23.623 1.00 25.94 ? 403 HOH   A O    1 
HETATM 5221 O O    . HOH   I 5 .   ? 30.983 16.364  26.659 1.00 23.96 ? 404 HOH   A O    1 
HETATM 5222 O O    . HOH   I 5 .   ? 46.009 -0.339  7.390  1.00 20.81 ? 405 HOH   A O    1 
HETATM 5223 O O    . HOH   I 5 .   ? 41.044 -7.747  10.409 1.00 33.24 ? 406 HOH   A O    1 
HETATM 5224 O O    . HOH   I 5 .   ? 31.606 7.616   4.440  1.00 27.67 ? 407 HOH   A O    1 
HETATM 5225 O O    . HOH   I 5 .   ? 10.330 -1.782  11.564 1.00 35.96 ? 408 HOH   A O    1 
HETATM 5226 O O    . HOH   I 5 .   ? 39.561 19.475  19.985 1.00 35.46 ? 409 HOH   A O    1 
HETATM 5227 O O    . HOH   I 5 .   ? 30.577 11.789  16.149 1.00 23.91 ? 410 HOH   A O    1 
HETATM 5228 O O    . HOH   I 5 .   ? 20.638 22.029  24.021 1.00 37.03 ? 411 HOH   A O    1 
HETATM 5229 O O    . HOH   I 5 .   ? 53.991 -18.571 12.294 1.00 30.21 ? 412 HOH   A O    1 
HETATM 5230 O O    . HOH   I 5 .   ? 35.141 11.774  27.296 1.00 31.61 ? 413 HOH   A O    1 
HETATM 5231 O O    . HOH   I 5 .   ? 57.480 -1.157  15.845 1.00 35.32 ? 414 HOH   A O    1 
HETATM 5232 O O    . HOH   I 5 .   ? 32.185 13.737  16.649 1.00 33.46 ? 415 HOH   A O    1 
HETATM 5233 O O    . HOH   I 5 .   ? 29.031 14.279  4.513  1.00 24.93 ? 416 HOH   A O    1 
HETATM 5234 O O    . HOH   I 5 .   ? 54.539 -6.024  11.157 1.00 26.71 ? 417 HOH   A O    1 
HETATM 5235 O O    . HOH   I 5 .   ? 25.542 12.017  5.570  1.00 35.70 ? 418 HOH   A O    1 
HETATM 5236 O O    A HOH   I 5 .   ? 19.803 14.919  24.913 0.72 25.27 ? 419 HOH   A O    1 
HETATM 5237 O O    B HOH   I 5 .   ? 17.905 14.061  24.243 0.28 21.55 ? 419 HOH   A O    1 
HETATM 5238 O O    . HOH   I 5 .   ? 33.887 18.891  3.272  1.00 32.38 ? 420 HOH   A O    1 
HETATM 5239 O O    . HOH   I 5 .   ? 38.044 6.582   27.579 1.00 36.69 ? 421 HOH   A O    1 
HETATM 5240 O O    . HOH   I 5 .   ? 24.350 3.050   3.396  1.00 47.66 ? 422 HOH   A O    1 
HETATM 5241 O O    . HOH   I 5 .   ? 29.835 -9.179  5.070  1.00 39.63 ? 423 HOH   A O    1 
HETATM 5242 O O    . HOH   I 5 .   ? 24.323 0.952   2.393  1.00 48.42 ? 424 HOH   A O    1 
HETATM 5243 O O    . HOH   I 5 .   ? 41.596 3.914   26.546 1.00 40.50 ? 425 HOH   A O    1 
HETATM 5244 O O    . HOH   I 5 .   ? 55.399 -10.767 17.973 1.00 33.28 ? 426 HOH   A O    1 
HETATM 5245 O O    . HOH   I 5 .   ? 50.934 3.137   5.419  1.00 36.59 ? 427 HOH   A O    1 
HETATM 5246 O O    . HOH   I 5 .   ? 28.985 9.142   1.172  1.00 41.72 ? 428 HOH   A O    1 
HETATM 5247 O O    . HOH   I 5 .   ? 48.155 -0.333  6.001  1.00 41.80 ? 429 HOH   A O    1 
HETATM 5248 O O    . HOH   I 5 .   ? 15.301 -10.319 21.980 1.00 41.97 ? 430 HOH   A O    1 
HETATM 5249 O O    . HOH   I 5 .   ? 43.245 -24.432 10.455 1.00 43.82 ? 431 HOH   A O    1 
HETATM 5250 O O    . HOH   I 5 .   ? 30.583 -2.141  25.889 1.00 33.28 ? 432 HOH   A O    1 
HETATM 5251 O O    . HOH   I 5 .   ? 35.805 -5.737  14.106 1.00 20.91 ? 433 HOH   A O    1 
HETATM 5252 O O    . HOH   I 5 .   ? 31.284 18.367  4.310  1.00 36.35 ? 434 HOH   A O    1 
HETATM 5253 O O    . HOH   I 5 .   ? 28.021 17.663  26.359 1.00 33.94 ? 435 HOH   A O    1 
HETATM 5254 O O    . HOH   I 5 .   ? 33.292 10.245  17.199 1.00 37.40 ? 436 HOH   A O    1 
HETATM 5255 O O    . HOH   I 5 .   ? 0.710  -0.883  17.497 1.00 30.00 ? 437 HOH   A O    1 
HETATM 5256 O O    . HOH   I 5 .   ? 24.369 20.641  22.164 1.00 44.28 ? 438 HOH   A O    1 
HETATM 5257 O O    . HOH   I 5 .   ? 42.282 7.913   1.106  1.00 43.36 ? 439 HOH   A O    1 
HETATM 5258 O O    . HOH   I 5 .   ? 27.474 22.252  18.404 1.00 41.99 ? 440 HOH   A O    1 
HETATM 5259 O O    . HOH   I 5 .   ? 50.795 15.011  6.757  1.00 42.31 ? 441 HOH   A O    1 
HETATM 5260 O O    . HOH   I 5 .   ? 26.185 3.144   1.212  1.00 39.06 ? 442 HOH   A O    1 
HETATM 5261 O O    . HOH   I 5 .   ? 32.457 -8.551  4.851  1.00 40.51 ? 443 HOH   A O    1 
HETATM 5262 O O    . HOH   I 5 .   ? 38.999 21.144  9.286  1.00 50.63 ? 444 HOH   A O    1 
HETATM 5263 O O    . HOH   I 5 .   ? 46.945 -20.799 10.079 1.00 46.84 ? 445 HOH   A O    1 
HETATM 5264 O O    . HOH   I 5 .   ? 45.124 2.189   23.076 1.00 35.92 ? 446 HOH   A O    1 
HETATM 5265 O O    . HOH   I 5 .   ? 22.203 -5.318  5.265  1.00 46.52 ? 447 HOH   A O    1 
HETATM 5266 O O    . HOH   I 5 .   ? 44.319 -28.908 9.372  1.00 49.68 ? 448 HOH   A O    1 
HETATM 5267 O O    . HOH   I 5 .   ? 50.945 7.895   2.852  1.00 46.38 ? 449 HOH   A O    1 
HETATM 5268 O O    . HOH   I 5 .   ? 30.094 16.423  2.989  1.00 43.14 ? 450 HOH   A O    1 
HETATM 5269 O O    . HOH   I 5 .   ? 34.536 13.769  -2.983 1.00 28.66 ? 451 HOH   A O    1 
HETATM 5270 O O    . HOH   I 5 .   ? 26.896 15.996  28.969 1.00 50.25 ? 452 HOH   A O    1 
HETATM 5271 O O    . HOH   I 5 .   ? 45.335 -18.811 7.201  1.00 47.61 ? 453 HOH   A O    1 
HETATM 5272 O O    . HOH   I 5 .   ? 44.104 -22.683 9.739  1.00 46.06 ? 454 HOH   A O    1 
HETATM 5273 O O    . HOH   I 5 .   ? 51.431 -11.445 8.704  1.00 50.25 ? 455 HOH   A O    1 
HETATM 5274 O O    . HOH   I 5 .   ? 19.212 -4.362  26.088 1.00 43.69 ? 456 HOH   A O    1 
HETATM 5275 O O    . HOH   I 5 .   ? 1.967  3.550   19.325 1.00 39.28 ? 457 HOH   A O    1 
HETATM 5276 O O    . HOH   I 5 .   ? 57.036 2.230   15.235 1.00 44.02 ? 458 HOH   A O    1 
HETATM 5277 O O    . HOH   I 5 .   ? 17.139 -6.663  22.301 1.00 44.45 ? 459 HOH   A O    1 
HETATM 5278 O O    . HOH   I 5 .   ? 22.419 9.852   4.389  1.00 39.32 ? 460 HOH   A O    1 
HETATM 5279 O O    . HOH   I 5 .   ? 25.590 10.361  0.978  1.00 47.72 ? 461 HOH   A O    1 
HETATM 5280 O O    . HOH   I 5 .   ? 55.154 4.136   8.027  1.00 34.10 ? 462 HOH   A O    1 
HETATM 5281 O O    . HOH   I 5 .   ? 56.567 7.751   18.057 1.00 50.65 ? 463 HOH   A O    1 
HETATM 5282 O O    . HOH   I 5 .   ? 28.186 13.878  29.371 1.00 42.62 ? 464 HOH   A O    1 
HETATM 5283 O O    . HOH   I 5 .   ? 22.324 15.204  29.459 1.00 47.92 ? 465 HOH   A O    1 
HETATM 5284 O O    . HOH   I 5 .   ? 9.117  8.666   15.575 1.00 45.94 ? 466 HOH   A O    1 
HETATM 5285 O O    . HOH   I 5 .   ? 24.499 16.191  29.441 1.00 51.16 ? 467 HOH   A O    1 
HETATM 5286 O O    . HOH   I 5 .   ? 26.565 14.731  5.814  1.00 35.78 ? 468 HOH   A O    1 
HETATM 5287 O O    . HOH   I 5 .   ? 57.613 3.889   10.141 1.00 44.81 ? 469 HOH   A O    1 
HETATM 5288 O O    . HOH   I 5 .   ? 58.316 5.687   13.386 1.00 39.03 ? 470 HOH   A O    1 
HETATM 5289 O O    . HOH   I 5 .   ? 23.277 3.033   26.130 1.00 48.15 ? 471 HOH   A O    1 
HETATM 5290 O O    . HOH   I 5 .   ? 41.981 19.278  18.803 1.00 41.72 ? 472 HOH   A O    1 
HETATM 5291 O O    . HOH   I 5 .   ? 28.484 20.816  7.901  1.00 46.50 ? 473 HOH   A O    1 
HETATM 5292 O O    . HOH   I 5 .   ? 13.546 2.208   6.914  1.00 43.27 ? 474 HOH   A O    1 
HETATM 5293 O O    . HOH   I 5 .   ? 19.826 3.153   25.900 1.00 40.24 ? 475 HOH   A O    1 
HETATM 5294 O O    . HOH   I 5 .   ? 38.243 21.652  19.512 1.00 47.19 ? 476 HOH   A O    1 
HETATM 5295 O O    . HOH   I 5 .   ? 59.412 -19.765 11.330 1.00 45.72 ? 477 HOH   A O    1 
HETATM 5296 O O    . HOH   I 5 .   ? 11.477 8.759   16.502 1.00 45.89 ? 478 HOH   A O    1 
HETATM 5297 O O    . HOH   I 5 .   ? 26.350 19.030  8.890  1.00 45.47 ? 479 HOH   A O    1 
HETATM 5298 O O    . HOH   I 5 .   ? 56.702 10.054  4.929  1.00 43.17 ? 480 HOH   A O    1 
HETATM 5299 O O    . HOH   I 5 .   ? 23.738 11.576  4.197  1.00 47.55 ? 481 HOH   A O    1 
HETATM 5300 O O    . HOH   I 5 .   ? 34.345 22.397  15.310 1.00 39.87 ? 482 HOH   A O    1 
HETATM 5301 O O    . HOH   I 5 .   ? 40.873 -27.097 7.788  1.00 37.31 ? 483 HOH   A O    1 
HETATM 5302 O O    . HOH   J 5 .   ? 6.351  -16.966 9.434  1.00 48.30 ? 301 HOH   B O    1 
HETATM 5303 O O    . HOH   J 5 .   ? 33.067 -19.698 17.667 1.00 20.34 ? 302 HOH   B O    1 
HETATM 5304 O O    . HOH   J 5 .   ? 41.452 -31.244 9.795  1.00 42.42 ? 303 HOH   B O    1 
HETATM 5305 O O    . HOH   J 5 .   ? 41.833 -25.700 14.167 1.00 42.68 ? 304 HOH   B O    1 
HETATM 5306 O O    . HOH   J 5 .   ? 44.639 -28.041 29.904 1.00 41.74 ? 305 HOH   B O    1 
HETATM 5307 O O    . HOH   J 5 .   ? 53.758 16.569  21.255 1.00 32.72 ? 306 HOH   B O    1 
HETATM 5308 O O    . HOH   J 5 .   ? 36.557 -22.497 16.898 1.00 37.85 ? 307 HOH   B O    1 
HETATM 5309 O O    . HOH   J 5 .   ? 44.458 -16.282 6.767  1.00 35.44 ? 308 HOH   B O    1 
HETATM 5310 O O    . HOH   J 5 .   ? 37.574 -7.747  21.655 1.00 32.19 ? 309 HOH   B O    1 
HETATM 5311 O O    . HOH   J 5 .   ? 40.011 -10.259 8.379  1.00 35.05 ? 310 HOH   B O    1 
HETATM 5312 O O    . HOH   J 5 .   ? 32.689 -15.452 29.138 1.00 22.23 ? 311 HOH   B O    1 
HETATM 5313 O O    . HOH   J 5 .   ? 38.058 -22.560 19.082 1.00 29.39 ? 312 HOH   B O    1 
HETATM 5314 O O    . HOH   J 5 .   ? 54.898 -14.660 19.346 1.00 26.67 ? 313 HOH   B O    1 
HETATM 5315 O O    . HOH   J 5 .   ? 39.926 -17.387 32.685 1.00 25.95 ? 314 HOH   B O    1 
HETATM 5316 O O    . HOH   J 5 .   ? 32.375 -13.202 4.177  1.00 38.86 ? 315 HOH   B O    1 
HETATM 5317 O O    . HOH   J 5 .   ? 31.073 -35.432 11.568 1.00 38.27 ? 316 HOH   B O    1 
HETATM 5318 O O    . HOH   J 5 .   ? 50.386 -23.732 26.118 1.00 41.53 ? 317 HOH   B O    1 
HETATM 5319 O O    . HOH   J 5 .   ? 36.275 -28.237 2.785  1.00 43.19 ? 318 HOH   B O    1 
HETATM 5320 O O    . HOH   J 5 .   ? 17.916 -14.143 3.604  1.00 28.06 ? 319 HOH   B O    1 
HETATM 5321 O O    . HOH   J 5 .   ? 40.203 -21.152 33.420 1.00 24.69 ? 320 HOH   B O    1 
HETATM 5322 O O    . HOH   J 5 .   ? 39.953 -30.453 26.578 1.00 39.02 ? 321 HOH   B O    1 
HETATM 5323 O O    . HOH   J 5 .   ? 50.500 10.613  17.775 1.00 23.98 ? 322 HOH   B O    1 
HETATM 5324 O O    . HOH   J 5 .   ? 37.496 -18.477 33.018 1.00 22.86 ? 323 HOH   B O    1 
HETATM 5325 O O    . HOH   J 5 .   ? 32.691 -17.333 4.046  1.00 41.92 ? 324 HOH   B O    1 
HETATM 5326 O O    . HOH   J 5 .   ? 40.140 -15.349 20.013 1.00 20.02 ? 325 HOH   B O    1 
HETATM 5327 O O    . HOH   J 5 .   ? 34.800 -21.343 19.178 1.00 30.43 ? 326 HOH   B O    1 
HETATM 5328 O O    . HOH   J 5 .   ? 17.598 -20.621 6.287  1.00 25.04 ? 327 HOH   B O    1 
HETATM 5329 O O    . HOH   J 5 .   ? 14.507 -18.044 21.274 1.00 45.89 ? 328 HOH   B O    1 
HETATM 5330 O O    . HOH   J 5 .   ? 28.806 -14.493 8.910  1.00 15.55 ? 329 HOH   B O    1 
HETATM 5331 O O    . HOH   J 5 .   ? 36.964 -22.607 34.492 1.00 25.94 ? 330 HOH   B O    1 
HETATM 5332 O O    . HOH   J 5 .   ? 47.440 3.405   22.756 1.00 47.98 ? 331 HOH   B O    1 
HETATM 5333 O O    . HOH   J 5 .   ? 35.025 -4.136  25.441 1.00 44.15 ? 332 HOH   B O    1 
HETATM 5334 O O    . HOH   J 5 .   ? 12.232 -24.622 12.727 1.00 26.73 ? 333 HOH   B O    1 
HETATM 5335 O O    . HOH   J 5 .   ? 27.347 -8.600  25.518 1.00 25.40 ? 334 HOH   B O    1 
HETATM 5336 O O    . HOH   J 5 .   ? 51.545 -8.542  26.686 1.00 32.11 ? 335 HOH   B O    1 
HETATM 5337 O O    . HOH   J 5 .   ? 32.662 -22.528 14.432 1.00 26.19 ? 336 HOH   B O    1 
HETATM 5338 O O    . HOH   J 5 .   ? 36.107 -6.661  20.572 1.00 28.81 ? 337 HOH   B O    1 
HETATM 5339 O O    . HOH   J 5 .   ? 54.980 -15.652 25.345 1.00 28.28 ? 338 HOH   B O    1 
HETATM 5340 O O    . HOH   J 5 .   ? 37.624 -19.925 2.663  1.00 51.25 ? 339 HOH   B O    1 
HETATM 5341 O O    . HOH   J 5 .   ? 24.583 -31.400 10.092 1.00 34.41 ? 340 HOH   B O    1 
HETATM 5342 O O    . HOH   J 5 .   ? 50.566 -17.147 28.480 1.00 23.16 ? 341 HOH   B O    1 
HETATM 5343 O O    . HOH   J 5 .   ? 44.641 11.765  25.095 1.00 43.48 ? 342 HOH   B O    1 
HETATM 5344 O O    . HOH   J 5 .   ? 46.156 -15.232 8.087  1.00 46.31 ? 343 HOH   B O    1 
HETATM 5345 O O    . HOH   J 5 .   ? 44.011 -28.787 27.436 1.00 33.65 ? 344 HOH   B O    1 
HETATM 5346 O O    . HOH   J 5 .   ? 22.635 -16.236 4.446  1.00 33.78 ? 345 HOH   B O    1 
HETATM 5347 O O    . HOH   J 5 .   ? 29.798 -12.165 31.225 1.00 37.64 ? 346 HOH   B O    1 
HETATM 5348 O O    . HOH   J 5 .   ? 37.501 -14.949 34.982 1.00 18.14 ? 347 HOH   B O    1 
HETATM 5349 O O    . HOH   J 5 .   ? 34.009 -13.353 30.308 1.00 20.66 ? 348 HOH   B O    1 
HETATM 5350 O O    . HOH   J 5 .   ? 39.213 -22.147 27.504 1.00 15.04 ? 349 HOH   B O    1 
HETATM 5351 O O    . HOH   J 5 .   ? 25.573 -25.034 28.087 1.00 28.08 ? 350 HOH   B O    1 
HETATM 5352 O O    . HOH   J 5 .   ? 24.988 -30.253 7.537  1.00 31.42 ? 351 HOH   B O    1 
HETATM 5353 O O    . HOH   J 5 .   ? 51.580 -20.627 32.860 1.00 42.66 ? 352 HOH   B O    1 
HETATM 5354 O O    . HOH   J 5 .   ? 33.803 -25.445 27.120 1.00 18.23 ? 353 HOH   B O    1 
HETATM 5355 O O    . HOH   J 5 .   ? 26.814 -29.914 20.129 1.00 26.93 ? 354 HOH   B O    1 
HETATM 5356 O O    . HOH   J 5 .   ? 28.916 -20.727 26.297 1.00 25.86 ? 355 HOH   B O    1 
HETATM 5357 O O    . HOH   J 5 .   ? 32.384 -29.493 16.220 1.00 18.19 ? 356 HOH   B O    1 
HETATM 5358 O O    . HOH   J 5 .   ? 34.408 -34.018 11.253 1.00 35.95 ? 357 HOH   B O    1 
HETATM 5359 O O    . HOH   J 5 .   ? 30.158 -22.548 21.510 1.00 16.22 ? 358 HOH   B O    1 
HETATM 5360 O O    . HOH   J 5 .   ? 29.980 -34.404 21.814 1.00 35.00 ? 359 HOH   B O    1 
HETATM 5361 O O    . HOH   J 5 .   ? 17.488 -12.241 11.570 1.00 15.16 ? 360 HOH   B O    1 
HETATM 5362 O O    . HOH   J 5 .   ? 48.026 8.190   23.088 1.00 35.26 ? 361 HOH   B O    1 
HETATM 5363 O O    . HOH   J 5 .   ? 40.101 -28.730 10.335 1.00 31.95 ? 362 HOH   B O    1 
HETATM 5364 O O    . HOH   J 5 .   ? 48.852 -20.640 25.805 1.00 20.73 ? 363 HOH   B O    1 
HETATM 5365 O O    . HOH   J 5 .   ? 34.485 -33.325 16.374 1.00 23.78 ? 364 HOH   B O    1 
HETATM 5366 O O    . HOH   J 5 .   ? 20.389 -18.381 2.728  1.00 41.12 ? 365 HOH   B O    1 
HETATM 5367 O O    . HOH   J 5 .   ? 41.389 -15.752 4.676  1.00 39.68 ? 366 HOH   B O    1 
HETATM 5368 O O    . HOH   J 5 .   ? 13.067 -14.692 16.212 1.00 41.50 ? 367 HOH   B O    1 
HETATM 5369 O O    . HOH   J 5 .   ? 38.862 12.955  22.050 1.00 42.03 ? 368 HOH   B O    1 
HETATM 5370 O O    . HOH   J 5 .   ? 50.954 -10.260 28.704 1.00 40.47 ? 369 HOH   B O    1 
HETATM 5371 O O    . HOH   J 5 .   ? 38.279 5.964   16.147 1.00 35.91 ? 370 HOH   B O    1 
HETATM 5372 O O    . HOH   J 5 .   ? 39.855 -8.841  27.907 1.00 37.73 ? 371 HOH   B O    1 
HETATM 5373 O O    . HOH   J 5 .   ? 40.618 -32.416 22.260 1.00 34.39 ? 372 HOH   B O    1 
HETATM 5374 O O    . HOH   J 5 .   ? 54.925 0.485   22.165 1.00 38.27 ? 373 HOH   B O    1 
HETATM 5375 O O    . HOH   J 5 .   ? 20.111 -29.818 18.934 1.00 48.59 ? 374 HOH   B O    1 
HETATM 5376 O O    . HOH   J 5 .   ? 31.860 -31.157 4.866  1.00 28.59 ? 375 HOH   B O    1 
HETATM 5377 O O    . HOH   J 5 .   ? 55.190 -8.452  19.923 1.00 36.10 ? 376 HOH   B O    1 
HETATM 5378 O O    . HOH   J 5 .   ? 34.813 -25.032 20.364 1.00 19.34 ? 377 HOH   B O    1 
HETATM 5379 O O    . HOH   J 5 .   ? 26.005 -27.632 19.277 1.00 26.53 ? 378 HOH   B O    1 
HETATM 5380 O O    . HOH   J 5 .   ? 26.519 -4.200  24.665 1.00 29.85 ? 379 HOH   B O    1 
HETATM 5381 O O    . HOH   J 5 .   ? 37.689 -29.769 28.140 1.00 39.19 ? 380 HOH   B O    1 
HETATM 5382 O O    . HOH   J 5 .   ? 17.894 -11.521 21.851 1.00 37.82 ? 381 HOH   B O    1 
HETATM 5383 O O    . HOH   J 5 .   ? 20.560 -7.794  24.392 1.00 43.47 ? 382 HOH   B O    1 
HETATM 5384 O O    . HOH   J 5 .   ? 52.988 14.757  24.513 1.00 49.96 ? 383 HOH   B O    1 
HETATM 5385 O O    . HOH   J 5 .   ? 36.073 -20.260 31.301 1.00 17.99 ? 384 HOH   B O    1 
HETATM 5386 O O    . HOH   J 5 .   ? 33.495 -26.563 18.542 1.00 21.80 ? 385 HOH   B O    1 
HETATM 5387 O O    . HOH   J 5 .   ? 31.691 -25.219 15.140 1.00 22.95 ? 386 HOH   B O    1 
HETATM 5388 O O    . HOH   J 5 .   ? 15.984 -21.058 8.513  1.00 23.94 ? 387 HOH   B O    1 
HETATM 5389 O O    . HOH   J 5 .   ? 13.358 -18.589 18.350 1.00 41.50 ? 388 HOH   B O    1 
HETATM 5390 O O    . HOH   J 5 .   ? 42.271 -10.170 10.485 1.00 20.90 ? 389 HOH   B O    1 
HETATM 5391 O O    . HOH   J 5 .   ? 12.131 -11.343 18.601 1.00 47.72 ? 390 HOH   B O    1 
HETATM 5392 O O    . HOH   J 5 .   ? 38.103 -8.069  10.417 1.00 30.60 ? 391 HOH   B O    1 
HETATM 5393 O O    . HOH   J 5 .   ? 22.478 -13.994 5.036  1.00 29.75 ? 392 HOH   B O    1 
HETATM 5394 O O    . HOH   J 5 .   ? 56.960 14.055  23.632 1.00 41.03 ? 393 HOH   B O    1 
HETATM 5395 O O    . HOH   J 5 .   ? 54.657 -2.162  24.610 1.00 43.89 ? 394 HOH   B O    1 
HETATM 5396 O O    . HOH   J 5 .   ? 43.711 -5.404  28.947 1.00 42.82 ? 395 HOH   B O    1 
HETATM 5397 O O    . HOH   J 5 .   ? 52.691 -23.227 30.778 1.00 39.03 ? 396 HOH   B O    1 
HETATM 5398 O O    . HOH   J 5 .   ? 29.412 -12.230 4.826  1.00 28.21 ? 397 HOH   B O    1 
HETATM 5399 O O    . HOH   J 5 .   ? 49.037 -26.536 30.377 1.00 45.68 ? 398 HOH   B O    1 
HETATM 5400 O O    . HOH   J 5 .   ? 39.560 -25.057 5.555  1.00 32.52 ? 399 HOH   B O    1 
HETATM 5401 O O    . HOH   J 5 .   ? 35.503 -19.987 14.831 1.00 35.12 ? 400 HOH   B O    1 
HETATM 5402 O O    . HOH   J 5 .   ? 35.222 -30.909 27.802 1.00 43.29 ? 401 HOH   B O    1 
HETATM 5403 O O    . HOH   J 5 .   ? 28.245 -25.061 31.607 1.00 27.12 ? 402 HOH   B O    1 
HETATM 5404 O O    . HOH   J 5 .   ? 19.942 -12.334 23.609 1.00 28.32 ? 403 HOH   B O    1 
HETATM 5405 O O    . HOH   J 5 .   ? 41.742 -19.051 6.149  1.00 34.12 ? 404 HOH   B O    1 
HETATM 5406 O O    . HOH   J 5 .   ? 32.552 -23.032 24.365 1.00 24.55 ? 405 HOH   B O    1 
HETATM 5407 O O    . HOH   J 5 .   ? 56.487 -10.589 22.557 1.00 33.97 ? 406 HOH   B O    1 
HETATM 5408 O O    A HOH   J 5 .   ? 33.827 -11.253 5.364  0.62 23.30 ? 407 HOH   B O    1 
HETATM 5409 O O    B HOH   J 5 .   ? 34.344 -9.940  5.778  0.38 21.30 ? 407 HOH   B O    1 
HETATM 5410 O O    . HOH   J 5 .   ? 51.805 -10.328 12.030 1.00 40.29 ? 408 HOH   B O    1 
HETATM 5411 O O    . HOH   J 5 .   ? 24.345 -28.875 3.694  1.00 30.34 ? 409 HOH   B O    1 
HETATM 5412 O O    . HOH   J 5 .   ? 33.530 -27.093 15.387 1.00 28.85 ? 410 HOH   B O    1 
HETATM 5413 O O    . HOH   J 5 .   ? 42.666 -22.340 8.065  1.00 50.06 ? 411 HOH   B O    1 
HETATM 5414 O O    . HOH   J 5 .   ? 31.206 -31.913 28.702 1.00 33.17 ? 412 HOH   B O    1 
HETATM 5415 O O    . HOH   J 5 .   ? 23.841 -25.773 23.433 1.00 31.03 ? 413 HOH   B O    1 
HETATM 5416 O O    . HOH   J 5 .   ? 26.846 -27.600 25.910 1.00 22.82 ? 414 HOH   B O    1 
HETATM 5417 O O    . HOH   J 5 .   ? 46.101 -13.309 31.311 1.00 42.76 ? 415 HOH   B O    1 
HETATM 5418 O O    . HOH   J 5 .   ? 10.809 -10.783 8.175  1.00 42.85 ? 416 HOH   B O    1 
HETATM 5419 O O    . HOH   J 5 .   ? 15.447 -18.604 3.948  1.00 37.65 ? 417 HOH   B O    1 
HETATM 5420 O O    . HOH   J 5 .   ? 47.596 -15.441 30.649 1.00 29.04 ? 418 HOH   B O    1 
HETATM 5421 O O    . HOH   J 5 .   ? 49.777 -10.003 6.575  1.00 44.47 ? 419 HOH   B O    1 
HETATM 5422 O O    . HOH   J 5 .   ? 16.361 -26.463 8.178  1.00 36.51 ? 420 HOH   B O    1 
HETATM 5423 O O    . HOH   J 5 .   ? 29.044 -31.225 26.904 1.00 35.93 ? 421 HOH   B O    1 
HETATM 5424 O O    . HOH   J 5 .   ? 38.398 -6.475  24.069 1.00 37.89 ? 422 HOH   B O    1 
HETATM 5425 O O    . HOH   J 5 .   ? 50.866 -17.101 31.668 1.00 48.44 ? 423 HOH   B O    1 
HETATM 5426 O O    . HOH   J 5 .   ? 30.050 -19.533 3.438  1.00 34.16 ? 424 HOH   B O    1 
HETATM 5427 O O    . HOH   J 5 .   ? 11.755 -20.778 6.212  1.00 43.76 ? 425 HOH   B O    1 
HETATM 5428 O O    . HOH   J 5 .   ? 43.006 -12.082 28.060 1.00 29.71 ? 426 HOH   B O    1 
HETATM 5429 O O    . HOH   J 5 .   ? 24.914 -30.318 17.183 1.00 46.49 ? 427 HOH   B O    1 
HETATM 5430 O O    . HOH   J 5 .   ? 21.255 -16.732 25.738 1.00 47.44 ? 428 HOH   B O    1 
HETATM 5431 O O    . HOH   J 5 .   ? 47.992 13.580  24.131 1.00 45.81 ? 429 HOH   B O    1 
HETATM 5432 O O    . HOH   J 5 .   ? 21.413 -9.105  3.869  1.00 34.02 ? 430 HOH   B O    1 
HETATM 5433 O O    . HOH   J 5 .   ? 52.186 -5.835  26.306 1.00 29.05 ? 431 HOH   B O    1 
HETATM 5434 O O    . HOH   J 5 .   ? 42.467 -30.478 14.875 1.00 40.46 ? 432 HOH   B O    1 
HETATM 5435 O O    . HOH   J 5 .   ? 45.666 6.595   22.853 1.00 33.64 ? 433 HOH   B O    1 
HETATM 5436 O O    . HOH   J 5 .   ? 49.824 -4.847  27.256 1.00 40.07 ? 434 HOH   B O    1 
HETATM 5437 O O    . HOH   J 5 .   ? 43.245 -33.597 21.670 1.00 46.91 ? 435 HOH   B O    1 
HETATM 5438 O O    . HOH   J 5 .   ? 27.855 -35.157 9.566  1.00 51.17 ? 436 HOH   B O    1 
HETATM 5439 O O    . HOH   J 5 .   ? 33.980 -22.609 21.891 1.00 25.65 ? 437 HOH   B O    1 
HETATM 5440 O O    . HOH   J 5 .   ? 37.485 -35.113 23.905 1.00 47.34 ? 438 HOH   B O    1 
HETATM 5441 O O    . HOH   J 5 .   ? 34.843 -30.433 5.215  1.00 27.94 ? 439 HOH   B O    1 
HETATM 5442 O O    . HOH   J 5 .   ? 29.161 -7.279  26.447 1.00 50.83 ? 440 HOH   B O    1 
HETATM 5443 O O    . HOH   J 5 .   ? 18.142 -20.342 2.867  1.00 36.54 ? 441 HOH   B O    1 
HETATM 5444 O O    . HOH   J 5 .   ? 22.298 -16.536 27.634 1.00 27.89 ? 442 HOH   B O    1 
HETATM 5445 O O    . HOH   J 5 .   ? 40.011 -15.545 31.550 1.00 31.56 ? 443 HOH   B O    1 
HETATM 5446 O O    . HOH   J 5 .   ? 36.952 -6.372  16.398 1.00 24.16 ? 444 HOH   B O    1 
HETATM 5447 O O    . HOH   J 5 .   ? 36.211 -9.002  27.956 1.00 38.68 ? 445 HOH   B O    1 
HETATM 5448 O O    . HOH   J 5 .   ? 3.152  -15.685 4.007  1.00 49.95 ? 446 HOH   B O    1 
HETATM 5449 O O    . HOH   J 5 .   ? 20.861 -14.803 25.097 1.00 42.97 ? 447 HOH   B O    1 
HETATM 5450 O O    . HOH   J 5 .   ? 17.829 -3.442  4.295  1.00 39.13 ? 448 HOH   B O    1 
HETATM 5451 O O    . HOH   J 5 .   ? 31.567 -33.363 3.667  1.00 42.02 ? 449 HOH   B O    1 
HETATM 5452 O O    . HOH   J 5 .   ? 50.690 11.650  23.604 1.00 47.25 ? 450 HOH   B O    1 
HETATM 5453 O O    . HOH   J 5 .   ? 35.146 -7.066  18.193 1.00 22.91 ? 451 HOH   B O    1 
HETATM 5454 O O    . HOH   J 5 .   ? 11.054 -14.672 14.516 1.00 44.93 ? 452 HOH   B O    1 
HETATM 5455 O O    . HOH   J 5 .   ? 28.662 -4.516  26.268 1.00 41.39 ? 453 HOH   B O    1 
HETATM 5456 O O    . HOH   J 5 .   ? 11.653 -22.728 9.971  1.00 41.53 ? 454 HOH   B O    1 
HETATM 5457 O O    . HOH   J 5 .   ? 37.515 7.166   17.842 1.00 49.29 ? 455 HOH   B O    1 
HETATM 5458 O O    . HOH   J 5 .   ? 56.341 -13.750 23.660 1.00 48.14 ? 456 HOH   B O    1 
HETATM 5459 O O    . HOH   J 5 .   ? 21.138 -22.426 27.715 1.00 45.85 ? 457 HOH   B O    1 
HETATM 5460 O O    . HOH   J 5 .   ? 37.335 12.855  25.321 1.00 44.64 ? 458 HOH   B O    1 
HETATM 5461 O O    . HOH   J 5 .   ? 46.961 -19.706 34.214 1.00 45.15 ? 459 HOH   B O    1 
HETATM 5462 O O    . HOH   J 5 .   ? 19.775 -8.337  22.700 1.00 44.64 ? 460 HOH   B O    1 
HETATM 5463 O O    . HOH   J 5 .   ? 34.124 -26.766 29.546 1.00 30.92 ? 461 HOH   B O    1 
HETATM 5464 O O    . HOH   J 5 .   ? 40.622 -25.370 32.678 1.00 45.82 ? 462 HOH   B O    1 
HETATM 5465 O O    . HOH   J 5 .   ? 55.662 16.084  23.614 1.00 35.88 ? 463 HOH   B O    1 
HETATM 5466 O O    . HOH   J 5 .   ? 46.282 -11.305 29.985 1.00 41.79 ? 464 HOH   B O    1 
HETATM 5467 O O    . HOH   J 5 .   ? 37.878 -7.722  26.945 1.00 41.61 ? 465 HOH   B O    1 
HETATM 5468 O O    . HOH   J 5 .   ? 37.477 -17.422 3.277  1.00 56.13 ? 466 HOH   B O    1 
HETATM 5469 O O    . HOH   J 5 .   ? 30.746 -35.911 14.983 1.00 47.21 ? 467 HOH   B O    1 
HETATM 5470 O O    . HOH   J 5 .   ? 34.962 -34.947 13.625 1.00 42.10 ? 468 HOH   B O    1 
HETATM 5471 O O    . HOH   J 5 .   ? 20.245 -7.165  4.734  1.00 44.01 ? 469 HOH   B O    1 
HETATM 5472 O O    . HOH   J 5 .   ? 52.573 -15.698 29.480 1.00 37.28 ? 470 HOH   B O    1 
HETATM 5473 O O    . HOH   J 5 .   ? 53.215 -25.226 27.996 1.00 55.27 ? 471 HOH   B O    1 
HETATM 5474 O O    . HOH   J 5 .   ? 36.966 -27.823 31.837 1.00 43.68 ? 472 HOH   B O    1 
HETATM 5475 O O    . HOH   J 5 .   ? 4.953  -19.947 9.665  1.00 35.93 ? 473 HOH   B O    1 
HETATM 5476 O O    . HOH   J 5 .   ? 39.568 -25.835 3.009  1.00 49.07 ? 474 HOH   B O    1 
HETATM 5477 O O    . HOH   J 5 .   ? 42.056 -28.471 12.204 1.00 47.55 ? 475 HOH   B O    1 
HETATM 5478 O O    . HOH   J 5 .   ? 40.536 -32.363 24.723 1.00 43.52 ? 476 HOH   B O    1 
HETATM 5479 O O    . HOH   J 5 .   ? 24.893 -33.746 9.523  1.00 40.75 ? 477 HOH   B O    1 
HETATM 5480 O O    . HOH   J 5 .   ? 22.915 -30.685 5.673  1.00 40.03 ? 478 HOH   B O    1 
HETATM 5481 O O    . HOH   J 5 .   ? 33.377 -27.600 1.798  1.00 41.44 ? 479 HOH   B O    1 
HETATM 5482 O O    . HOH   J 5 .   ? 47.452 -17.231 34.305 1.00 47.46 ? 480 HOH   B O    1 
HETATM 5483 O O    . HOH   J 5 .   ? 55.468 -15.415 28.189 1.00 42.62 ? 481 HOH   B O    1 
HETATM 5484 O O    . HOH   J 5 .   ? 45.127 -6.563  30.850 1.00 48.02 ? 482 HOH   B O    1 
HETATM 5485 O O    . HOH   J 5 .   ? 24.040 -16.983 2.196  1.00 41.69 ? 483 HOH   B O    1 
HETATM 5486 O O    . HOH   J 5 .   ? 14.318 -22.805 8.202  1.00 38.04 ? 484 HOH   B O    1 
HETATM 5487 O O    . HOH   J 5 .   ? 30.997 -25.345 31.688 0.50 48.27 ? 485 HOH   B O    1 
HETATM 5488 O O    . HOH   J 5 .   ? 37.037 -26.050 0.208  1.00 48.19 ? 486 HOH   B O    1 
HETATM 5489 O O    . HOH   J 5 .   ? 25.360 -32.101 20.987 1.00 42.98 ? 487 HOH   B O    1 
HETATM 5490 O O    . HOH   J 5 .   ? 53.525 -17.474 32.351 1.00 47.85 ? 488 HOH   B O    1 
HETATM 5491 O O    . HOH   J 5 .   ? 26.615 -26.674 30.011 1.00 33.69 ? 489 HOH   B O    1 
HETATM 5492 O O    . HOH   J 5 .   ? 35.485 -35.665 17.522 1.00 36.30 ? 490 HOH   B O    1 
HETATM 5493 O O    . HOH   J 5 .   ? 38.635 -34.632 21.735 1.00 37.69 ? 491 HOH   B O    1 
# 
