data_9F7J
# 
_entry.id   9F7J 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9F7J         pdb_00009f7j 10.2210/pdb9f7j/pdb 
WWPDB D_1292138372 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-12-04 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9F7J 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              holger.sondermann@desy.de 
_pdbx_contact_author.name_first         Holger 
_pdbx_contact_author.name_last          Sondermann 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2211-6234 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Mortensen, S.'  1 0000-0003-1631-6651 
'Sondermann, H.' 2 0000-0003-2211-6234 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Unique dinucleases with DNA specificity  are associated with genomic islands in Actinomycetes and Clostridia' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Mortensen, S.'  1 0000-0003-1631-6651 
primary 'Sondermann, H.' 2 0000-0003-2211-6234 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man diDNase 23699.346 1   ? ? ? ? 
2 water   nat water   18.015    197 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SMKKIDPLASTVVVRDGDLSSSFLAAARQCGRVTIDTETTGLSPKIDGLCTVQLHVPGVGTEIVRVDPTLQPTRLLQVLA
AEEIVKGFHHAVFDLGFLRHTFQSKARSVVCSKVAAKILWPHDKDRQSLAGLAHLLLGVVLDKTPRLSDWSQPELTKTQV
HYAAVDVEILPPILDELDRLLSERQLRELAVACWHHIPAHVELLEHNLGDVFTY
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SMKKIDPLASTVVVRDGDLSSSFLAAARQCGRVTIDTETTGLSPKIDGLCTVQLHVPGVGTEIVRVDPTLQPTRLLQVLA
AEEIVKGFHHAVFDLGFLRHTFQSKARSVVCSKVAAKILWPHDKDRQSLAGLAHLLLGVVLDKTPRLSDWSQPELTKTQV
HYAAVDVEILPPILDELDRLLSERQLRELAVACWHHIPAHVELLEHNLGDVFTY
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   MET n 
1 3   LYS n 
1 4   LYS n 
1 5   ILE n 
1 6   ASP n 
1 7   PRO n 
1 8   LEU n 
1 9   ALA n 
1 10  SER n 
1 11  THR n 
1 12  VAL n 
1 13  VAL n 
1 14  VAL n 
1 15  ARG n 
1 16  ASP n 
1 17  GLY n 
1 18  ASP n 
1 19  LEU n 
1 20  SER n 
1 21  SER n 
1 22  SER n 
1 23  PHE n 
1 24  LEU n 
1 25  ALA n 
1 26  ALA n 
1 27  ALA n 
1 28  ARG n 
1 29  GLN n 
1 30  CYS n 
1 31  GLY n 
1 32  ARG n 
1 33  VAL n 
1 34  THR n 
1 35  ILE n 
1 36  ASP n 
1 37  THR n 
1 38  GLU n 
1 39  THR n 
1 40  THR n 
1 41  GLY n 
1 42  LEU n 
1 43  SER n 
1 44  PRO n 
1 45  LYS n 
1 46  ILE n 
1 47  ASP n 
1 48  GLY n 
1 49  LEU n 
1 50  CYS n 
1 51  THR n 
1 52  VAL n 
1 53  GLN n 
1 54  LEU n 
1 55  HIS n 
1 56  VAL n 
1 57  PRO n 
1 58  GLY n 
1 59  VAL n 
1 60  GLY n 
1 61  THR n 
1 62  GLU n 
1 63  ILE n 
1 64  VAL n 
1 65  ARG n 
1 66  VAL n 
1 67  ASP n 
1 68  PRO n 
1 69  THR n 
1 70  LEU n 
1 71  GLN n 
1 72  PRO n 
1 73  THR n 
1 74  ARG n 
1 75  LEU n 
1 76  LEU n 
1 77  GLN n 
1 78  VAL n 
1 79  LEU n 
1 80  ALA n 
1 81  ALA n 
1 82  GLU n 
1 83  GLU n 
1 84  ILE n 
1 85  VAL n 
1 86  LYS n 
1 87  GLY n 
1 88  PHE n 
1 89  HIS n 
1 90  HIS n 
1 91  ALA n 
1 92  VAL n 
1 93  PHE n 
1 94  ASP n 
1 95  LEU n 
1 96  GLY n 
1 97  PHE n 
1 98  LEU n 
1 99  ARG n 
1 100 HIS n 
1 101 THR n 
1 102 PHE n 
1 103 GLN n 
1 104 SER n 
1 105 LYS n 
1 106 ALA n 
1 107 ARG n 
1 108 SER n 
1 109 VAL n 
1 110 VAL n 
1 111 CYS n 
1 112 SER n 
1 113 LYS n 
1 114 VAL n 
1 115 ALA n 
1 116 ALA n 
1 117 LYS n 
1 118 ILE n 
1 119 LEU n 
1 120 TRP n 
1 121 PRO n 
1 122 HIS n 
1 123 ASP n 
1 124 LYS n 
1 125 ASP n 
1 126 ARG n 
1 127 GLN n 
1 128 SER n 
1 129 LEU n 
1 130 ALA n 
1 131 GLY n 
1 132 LEU n 
1 133 ALA n 
1 134 HIS n 
1 135 LEU n 
1 136 LEU n 
1 137 LEU n 
1 138 GLY n 
1 139 VAL n 
1 140 VAL n 
1 141 LEU n 
1 142 ASP n 
1 143 LYS n 
1 144 THR n 
1 145 PRO n 
1 146 ARG n 
1 147 LEU n 
1 148 SER n 
1 149 ASP n 
1 150 TRP n 
1 151 SER n 
1 152 GLN n 
1 153 PRO n 
1 154 GLU n 
1 155 LEU n 
1 156 THR n 
1 157 LYS n 
1 158 THR n 
1 159 GLN n 
1 160 VAL n 
1 161 HIS n 
1 162 TYR n 
1 163 ALA n 
1 164 ALA n 
1 165 VAL n 
1 166 ASP n 
1 167 VAL n 
1 168 GLU n 
1 169 ILE n 
1 170 LEU n 
1 171 PRO n 
1 172 PRO n 
1 173 ILE n 
1 174 LEU n 
1 175 ASP n 
1 176 GLU n 
1 177 LEU n 
1 178 ASP n 
1 179 ARG n 
1 180 LEU n 
1 181 LEU n 
1 182 SER n 
1 183 GLU n 
1 184 ARG n 
1 185 GLN n 
1 186 LEU n 
1 187 ARG n 
1 188 GLU n 
1 189 LEU n 
1 190 ALA n 
1 191 VAL n 
1 192 ALA n 
1 193 CYS n 
1 194 TRP n 
1 195 HIS n 
1 196 HIS n 
1 197 ILE n 
1 198 PRO n 
1 199 ALA n 
1 200 HIS n 
1 201 VAL n 
1 202 GLU n 
1 203 LEU n 
1 204 LEU n 
1 205 GLU n 
1 206 HIS n 
1 207 ASN n 
1 208 LEU n 
1 209 GLY n 
1 210 ASP n 
1 211 VAL n 
1 212 PHE n 
1 213 THR n 
1 214 TYR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   214 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Rhodococcus ruber' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1830 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   0   ?   ?   ?   A . n 
A 1 2   MET 2   1   ?   ?   ?   A . n 
A 1 3   LYS 3   2   ?   ?   ?   A . n 
A 1 4   LYS 4   3   ?   ?   ?   A . n 
A 1 5   ILE 5   4   ?   ?   ?   A . n 
A 1 6   ASP 6   5   ?   ?   ?   A . n 
A 1 7   PRO 7   6   ?   ?   ?   A . n 
A 1 8   LEU 8   7   ?   ?   ?   A . n 
A 1 9   ALA 9   8   ?   ?   ?   A . n 
A 1 10  SER 10  9   ?   ?   ?   A . n 
A 1 11  THR 11  10  10  THR THR A . n 
A 1 12  VAL 12  11  11  VAL VAL A . n 
A 1 13  VAL 13  12  12  VAL VAL A . n 
A 1 14  VAL 14  13  13  VAL VAL A . n 
A 1 15  ARG 15  14  14  ARG ARG A . n 
A 1 16  ASP 16  15  15  ASP ASP A . n 
A 1 17  GLY 17  16  16  GLY GLY A . n 
A 1 18  ASP 18  17  17  ASP ASP A . n 
A 1 19  LEU 19  18  18  LEU LEU A . n 
A 1 20  SER 20  19  19  SER SER A . n 
A 1 21  SER 21  20  20  SER SER A . n 
A 1 22  SER 22  21  21  SER SER A . n 
A 1 23  PHE 23  22  22  PHE PHE A . n 
A 1 24  LEU 24  23  23  LEU LEU A . n 
A 1 25  ALA 25  24  24  ALA ALA A . n 
A 1 26  ALA 26  25  25  ALA ALA A . n 
A 1 27  ALA 27  26  26  ALA ALA A . n 
A 1 28  ARG 28  27  27  ARG ARG A . n 
A 1 29  GLN 29  28  28  GLN GLN A . n 
A 1 30  CYS 30  29  29  CYS CYS A . n 
A 1 31  GLY 31  30  30  GLY GLY A . n 
A 1 32  ARG 32  31  31  ARG ARG A . n 
A 1 33  VAL 33  32  32  VAL VAL A . n 
A 1 34  THR 34  33  33  THR THR A . n 
A 1 35  ILE 35  34  34  ILE ILE A . n 
A 1 36  ASP 36  35  35  ASP ASP A . n 
A 1 37  THR 37  36  36  THR THR A . n 
A 1 38  GLU 38  37  37  GLU GLU A . n 
A 1 39  THR 39  38  38  THR THR A . n 
A 1 40  THR 40  39  39  THR THR A . n 
A 1 41  GLY 41  40  40  GLY GLY A . n 
A 1 42  LEU 42  41  41  LEU LEU A . n 
A 1 43  SER 43  42  42  SER SER A . n 
A 1 44  PRO 44  43  43  PRO PRO A . n 
A 1 45  LYS 45  44  44  LYS LYS A . n 
A 1 46  ILE 46  45  45  ILE ILE A . n 
A 1 47  ASP 47  46  46  ASP ASP A . n 
A 1 48  GLY 48  47  47  GLY GLY A . n 
A 1 49  LEU 49  48  48  LEU LEU A . n 
A 1 50  CYS 50  49  49  CYS CYS A . n 
A 1 51  THR 51  50  50  THR THR A . n 
A 1 52  VAL 52  51  51  VAL VAL A . n 
A 1 53  GLN 53  52  52  GLN GLN A . n 
A 1 54  LEU 54  53  53  LEU LEU A . n 
A 1 55  HIS 55  54  54  HIS HIS A . n 
A 1 56  VAL 56  55  55  VAL VAL A . n 
A 1 57  PRO 57  56  56  PRO PRO A . n 
A 1 58  GLY 58  57  57  GLY GLY A . n 
A 1 59  VAL 59  58  58  VAL VAL A . n 
A 1 60  GLY 60  59  59  GLY GLY A . n 
A 1 61  THR 61  60  60  THR THR A . n 
A 1 62  GLU 62  61  61  GLU GLU A . n 
A 1 63  ILE 63  62  62  ILE ILE A . n 
A 1 64  VAL 64  63  63  VAL VAL A . n 
A 1 65  ARG 65  64  64  ARG ARG A . n 
A 1 66  VAL 66  65  65  VAL VAL A . n 
A 1 67  ASP 67  66  66  ASP ASP A . n 
A 1 68  PRO 68  67  67  PRO PRO A . n 
A 1 69  THR 69  68  68  THR THR A . n 
A 1 70  LEU 70  69  69  LEU LEU A . n 
A 1 71  GLN 71  70  70  GLN GLN A . n 
A 1 72  PRO 72  71  71  PRO PRO A . n 
A 1 73  THR 73  72  72  THR THR A . n 
A 1 74  ARG 74  73  73  ARG ARG A . n 
A 1 75  LEU 75  74  74  LEU LEU A . n 
A 1 76  LEU 76  75  75  LEU LEU A . n 
A 1 77  GLN 77  76  76  GLN GLN A . n 
A 1 78  VAL 78  77  77  VAL VAL A . n 
A 1 79  LEU 79  78  78  LEU LEU A . n 
A 1 80  ALA 80  79  79  ALA ALA A . n 
A 1 81  ALA 81  80  80  ALA ALA A . n 
A 1 82  GLU 82  81  81  GLU GLU A . n 
A 1 83  GLU 83  82  82  GLU GLU A . n 
A 1 84  ILE 84  83  83  ILE ILE A . n 
A 1 85  VAL 85  84  84  VAL VAL A . n 
A 1 86  LYS 86  85  85  LYS LYS A . n 
A 1 87  GLY 87  86  86  GLY GLY A . n 
A 1 88  PHE 88  87  87  PHE PHE A . n 
A 1 89  HIS 89  88  88  HIS HIS A . n 
A 1 90  HIS 90  89  89  HIS HIS A . n 
A 1 91  ALA 91  90  90  ALA ALA A . n 
A 1 92  VAL 92  91  91  VAL VAL A . n 
A 1 93  PHE 93  92  92  PHE PHE A . n 
A 1 94  ASP 94  93  93  ASP ASP A . n 
A 1 95  LEU 95  94  94  LEU LEU A . n 
A 1 96  GLY 96  95  95  GLY GLY A . n 
A 1 97  PHE 97  96  96  PHE PHE A . n 
A 1 98  LEU 98  97  97  LEU LEU A . n 
A 1 99  ARG 99  98  98  ARG ARG A . n 
A 1 100 HIS 100 99  99  HIS HIS A . n 
A 1 101 THR 101 100 100 THR THR A . n 
A 1 102 PHE 102 101 101 PHE PHE A . n 
A 1 103 GLN 103 102 102 GLN GLN A . n 
A 1 104 SER 104 103 103 SER SER A . n 
A 1 105 LYS 105 104 104 LYS LYS A . n 
A 1 106 ALA 106 105 105 ALA ALA A . n 
A 1 107 ARG 107 106 106 ARG ARG A . n 
A 1 108 SER 108 107 107 SER SER A . n 
A 1 109 VAL 109 108 108 VAL VAL A . n 
A 1 110 VAL 110 109 109 VAL VAL A . n 
A 1 111 CYS 111 110 110 CYS CYS A . n 
A 1 112 SER 112 111 111 SER SER A . n 
A 1 113 LYS 113 112 112 LYS LYS A . n 
A 1 114 VAL 114 113 113 VAL VAL A . n 
A 1 115 ALA 115 114 114 ALA ALA A . n 
A 1 116 ALA 116 115 115 ALA ALA A . n 
A 1 117 LYS 117 116 116 LYS LYS A . n 
A 1 118 ILE 118 117 117 ILE ILE A . n 
A 1 119 LEU 119 118 118 LEU LEU A . n 
A 1 120 TRP 120 119 119 TRP TRP A . n 
A 1 121 PRO 121 120 120 PRO PRO A . n 
A 1 122 HIS 122 121 121 HIS HIS A . n 
A 1 123 ASP 123 122 122 ASP ASP A . n 
A 1 124 LYS 124 123 123 LYS LYS A . n 
A 1 125 ASP 125 124 124 ASP ASP A . n 
A 1 126 ARG 126 125 125 ARG ARG A . n 
A 1 127 GLN 127 126 126 GLN GLN A . n 
A 1 128 SER 128 127 127 SER SER A . n 
A 1 129 LEU 129 128 128 LEU LEU A . n 
A 1 130 ALA 130 129 129 ALA ALA A . n 
A 1 131 GLY 131 130 130 GLY GLY A . n 
A 1 132 LEU 132 131 131 LEU LEU A . n 
A 1 133 ALA 133 132 132 ALA ALA A . n 
A 1 134 HIS 134 133 133 HIS HIS A . n 
A 1 135 LEU 135 134 134 LEU LEU A . n 
A 1 136 LEU 136 135 135 LEU LEU A . n 
A 1 137 LEU 137 136 136 LEU LEU A . n 
A 1 138 GLY 138 137 137 GLY GLY A . n 
A 1 139 VAL 139 138 138 VAL VAL A . n 
A 1 140 VAL 140 139 139 VAL VAL A . n 
A 1 141 LEU 141 140 140 LEU LEU A . n 
A 1 142 ASP 142 141 141 ASP ASP A . n 
A 1 143 LYS 143 142 ?   ?   ?   A . n 
A 1 144 THR 144 143 ?   ?   ?   A . n 
A 1 145 PRO 145 144 ?   ?   ?   A . n 
A 1 146 ARG 146 145 ?   ?   ?   A . n 
A 1 147 LEU 147 146 ?   ?   ?   A . n 
A 1 148 SER 148 147 147 SER SER A . n 
A 1 149 ASP 149 148 148 ASP ASP A . n 
A 1 150 TRP 150 149 149 TRP TRP A . n 
A 1 151 SER 151 150 150 SER SER A . n 
A 1 152 GLN 152 151 151 GLN GLN A . n 
A 1 153 PRO 153 152 152 PRO PRO A . n 
A 1 154 GLU 154 153 153 GLU GLU A . n 
A 1 155 LEU 155 154 154 LEU LEU A . n 
A 1 156 THR 156 155 155 THR THR A . n 
A 1 157 LYS 157 156 156 LYS LYS A . n 
A 1 158 THR 158 157 157 THR THR A . n 
A 1 159 GLN 159 158 158 GLN GLN A . n 
A 1 160 VAL 160 159 159 VAL VAL A . n 
A 1 161 HIS 161 160 160 HIS HIS A . n 
A 1 162 TYR 162 161 161 TYR TYR A . n 
A 1 163 ALA 163 162 162 ALA ALA A . n 
A 1 164 ALA 164 163 163 ALA ALA A . n 
A 1 165 VAL 165 164 164 VAL VAL A . n 
A 1 166 ASP 166 165 165 ASP ASP A . n 
A 1 167 VAL 167 166 166 VAL VAL A . n 
A 1 168 GLU 168 167 167 GLU GLU A . n 
A 1 169 ILE 169 168 168 ILE ILE A . n 
A 1 170 LEU 170 169 169 LEU LEU A . n 
A 1 171 PRO 171 170 170 PRO PRO A . n 
A 1 172 PRO 172 171 171 PRO PRO A . n 
A 1 173 ILE 173 172 172 ILE ILE A . n 
A 1 174 LEU 174 173 173 LEU LEU A . n 
A 1 175 ASP 175 174 174 ASP ASP A . n 
A 1 176 GLU 176 175 175 GLU GLU A . n 
A 1 177 LEU 177 176 176 LEU LEU A . n 
A 1 178 ASP 178 177 177 ASP ASP A . n 
A 1 179 ARG 179 178 178 ARG ARG A . n 
A 1 180 LEU 180 179 179 LEU LEU A . n 
A 1 181 LEU 181 180 180 LEU LEU A . n 
A 1 182 SER 182 181 181 SER SER A . n 
A 1 183 GLU 183 182 182 GLU GLU A . n 
A 1 184 ARG 184 183 183 ARG ARG A . n 
A 1 185 GLN 185 184 184 GLN GLN A . n 
A 1 186 LEU 186 185 185 LEU LEU A . n 
A 1 187 ARG 187 186 186 ARG ARG A . n 
A 1 188 GLU 188 187 187 GLU GLU A . n 
A 1 189 LEU 189 188 188 LEU LEU A . n 
A 1 190 ALA 190 189 189 ALA ALA A . n 
A 1 191 VAL 191 190 190 VAL VAL A . n 
A 1 192 ALA 192 191 191 ALA ALA A . n 
A 1 193 CYS 193 192 192 CYS CYS A . n 
A 1 194 TRP 194 193 193 TRP TRP A . n 
A 1 195 HIS 195 194 194 HIS HIS A . n 
A 1 196 HIS 196 195 195 HIS HIS A . n 
A 1 197 ILE 197 196 196 ILE ILE A . n 
A 1 198 PRO 198 197 197 PRO PRO A . n 
A 1 199 ALA 199 198 198 ALA ALA A . n 
A 1 200 HIS 200 199 199 HIS HIS A . n 
A 1 201 VAL 201 200 200 VAL VAL A . n 
A 1 202 GLU 202 201 201 GLU GLU A . n 
A 1 203 LEU 203 202 202 LEU LEU A . n 
A 1 204 LEU 204 203 203 LEU LEU A . n 
A 1 205 GLU 205 204 204 GLU GLU A . n 
A 1 206 HIS 206 205 205 HIS HIS A . n 
A 1 207 ASN 207 206 206 ASN ASN A . n 
A 1 208 LEU 208 207 207 LEU LEU A . n 
A 1 209 GLY 209 208 208 GLY GLY A . n 
A 1 210 ASP 210 209 209 ASP ASP A . n 
A 1 211 VAL 211 210 210 VAL VAL A . n 
A 1 212 PHE 212 211 211 PHE PHE A . n 
A 1 213 THR 213 212 212 THR THR A . n 
A 1 214 TYR 214 213 213 TYR TYR A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   301 146 HOH HOH A . 
B 2 HOH 2   302 139 HOH HOH A . 
B 2 HOH 3   303 195 HOH HOH A . 
B 2 HOH 4   304 127 HOH HOH A . 
B 2 HOH 5   305 152 HOH HOH A . 
B 2 HOH 6   306 141 HOH HOH A . 
B 2 HOH 7   307 95  HOH HOH A . 
B 2 HOH 8   308 46  HOH HOH A . 
B 2 HOH 9   309 148 HOH HOH A . 
B 2 HOH 10  310 73  HOH HOH A . 
B 2 HOH 11  311 150 HOH HOH A . 
B 2 HOH 12  312 13  HOH HOH A . 
B 2 HOH 13  313 12  HOH HOH A . 
B 2 HOH 14  314 48  HOH HOH A . 
B 2 HOH 15  315 92  HOH HOH A . 
B 2 HOH 16  316 186 HOH HOH A . 
B 2 HOH 17  317 159 HOH HOH A . 
B 2 HOH 18  318 164 HOH HOH A . 
B 2 HOH 19  319 156 HOH HOH A . 
B 2 HOH 20  320 33  HOH HOH A . 
B 2 HOH 21  321 52  HOH HOH A . 
B 2 HOH 22  322 6   HOH HOH A . 
B 2 HOH 23  323 61  HOH HOH A . 
B 2 HOH 24  324 59  HOH HOH A . 
B 2 HOH 25  325 25  HOH HOH A . 
B 2 HOH 26  326 2   HOH HOH A . 
B 2 HOH 27  327 22  HOH HOH A . 
B 2 HOH 28  328 67  HOH HOH A . 
B 2 HOH 29  329 26  HOH HOH A . 
B 2 HOH 30  330 8   HOH HOH A . 
B 2 HOH 31  331 174 HOH HOH A . 
B 2 HOH 32  332 17  HOH HOH A . 
B 2 HOH 33  333 133 HOH HOH A . 
B 2 HOH 34  334 129 HOH HOH A . 
B 2 HOH 35  335 108 HOH HOH A . 
B 2 HOH 36  336 9   HOH HOH A . 
B 2 HOH 37  337 43  HOH HOH A . 
B 2 HOH 38  338 158 HOH HOH A . 
B 2 HOH 39  339 137 HOH HOH A . 
B 2 HOH 40  340 100 HOH HOH A . 
B 2 HOH 41  341 34  HOH HOH A . 
B 2 HOH 42  342 110 HOH HOH A . 
B 2 HOH 43  343 65  HOH HOH A . 
B 2 HOH 44  344 10  HOH HOH A . 
B 2 HOH 45  345 157 HOH HOH A . 
B 2 HOH 46  346 124 HOH HOH A . 
B 2 HOH 47  347 5   HOH HOH A . 
B 2 HOH 48  348 97  HOH HOH A . 
B 2 HOH 49  349 21  HOH HOH A . 
B 2 HOH 50  350 24  HOH HOH A . 
B 2 HOH 51  351 1   HOH HOH A . 
B 2 HOH 52  352 54  HOH HOH A . 
B 2 HOH 53  353 30  HOH HOH A . 
B 2 HOH 54  354 191 HOH HOH A . 
B 2 HOH 55  355 165 HOH HOH A . 
B 2 HOH 56  356 40  HOH HOH A . 
B 2 HOH 57  357 136 HOH HOH A . 
B 2 HOH 58  358 4   HOH HOH A . 
B 2 HOH 59  359 101 HOH HOH A . 
B 2 HOH 60  360 66  HOH HOH A . 
B 2 HOH 61  361 123 HOH HOH A . 
B 2 HOH 62  362 94  HOH HOH A . 
B 2 HOH 63  363 149 HOH HOH A . 
B 2 HOH 64  364 37  HOH HOH A . 
B 2 HOH 65  365 45  HOH HOH A . 
B 2 HOH 66  366 111 HOH HOH A . 
B 2 HOH 67  367 36  HOH HOH A . 
B 2 HOH 68  368 74  HOH HOH A . 
B 2 HOH 69  369 57  HOH HOH A . 
B 2 HOH 70  370 62  HOH HOH A . 
B 2 HOH 71  371 107 HOH HOH A . 
B 2 HOH 72  372 84  HOH HOH A . 
B 2 HOH 73  373 155 HOH HOH A . 
B 2 HOH 74  374 122 HOH HOH A . 
B 2 HOH 75  375 93  HOH HOH A . 
B 2 HOH 76  376 68  HOH HOH A . 
B 2 HOH 77  377 15  HOH HOH A . 
B 2 HOH 78  378 63  HOH HOH A . 
B 2 HOH 79  379 51  HOH HOH A . 
B 2 HOH 80  380 58  HOH HOH A . 
B 2 HOH 81  381 142 HOH HOH A . 
B 2 HOH 82  382 80  HOH HOH A . 
B 2 HOH 83  383 116 HOH HOH A . 
B 2 HOH 84  384 177 HOH HOH A . 
B 2 HOH 85  385 16  HOH HOH A . 
B 2 HOH 86  386 31  HOH HOH A . 
B 2 HOH 87  387 113 HOH HOH A . 
B 2 HOH 88  388 162 HOH HOH A . 
B 2 HOH 89  389 77  HOH HOH A . 
B 2 HOH 90  390 76  HOH HOH A . 
B 2 HOH 91  391 143 HOH HOH A . 
B 2 HOH 92  392 88  HOH HOH A . 
B 2 HOH 93  393 81  HOH HOH A . 
B 2 HOH 94  394 72  HOH HOH A . 
B 2 HOH 95  395 125 HOH HOH A . 
B 2 HOH 96  396 98  HOH HOH A . 
B 2 HOH 97  397 23  HOH HOH A . 
B 2 HOH 98  398 145 HOH HOH A . 
B 2 HOH 99  399 70  HOH HOH A . 
B 2 HOH 100 400 28  HOH HOH A . 
B 2 HOH 101 401 29  HOH HOH A . 
B 2 HOH 102 402 131 HOH HOH A . 
B 2 HOH 103 403 138 HOH HOH A . 
B 2 HOH 104 404 27  HOH HOH A . 
B 2 HOH 105 405 144 HOH HOH A . 
B 2 HOH 106 406 109 HOH HOH A . 
B 2 HOH 107 407 121 HOH HOH A . 
B 2 HOH 108 408 49  HOH HOH A . 
B 2 HOH 109 409 83  HOH HOH A . 
B 2 HOH 110 410 7   HOH HOH A . 
B 2 HOH 111 411 161 HOH HOH A . 
B 2 HOH 112 412 118 HOH HOH A . 
B 2 HOH 113 413 41  HOH HOH A . 
B 2 HOH 114 414 154 HOH HOH A . 
B 2 HOH 115 415 112 HOH HOH A . 
B 2 HOH 116 416 20  HOH HOH A . 
B 2 HOH 117 417 91  HOH HOH A . 
B 2 HOH 118 418 166 HOH HOH A . 
B 2 HOH 119 419 178 HOH HOH A . 
B 2 HOH 120 420 140 HOH HOH A . 
B 2 HOH 121 421 89  HOH HOH A . 
B 2 HOH 122 422 32  HOH HOH A . 
B 2 HOH 123 423 179 HOH HOH A . 
B 2 HOH 124 424 151 HOH HOH A . 
B 2 HOH 125 425 19  HOH HOH A . 
B 2 HOH 126 426 56  HOH HOH A . 
B 2 HOH 127 427 115 HOH HOH A . 
B 2 HOH 128 428 128 HOH HOH A . 
B 2 HOH 129 429 153 HOH HOH A . 
B 2 HOH 130 430 47  HOH HOH A . 
B 2 HOH 131 431 87  HOH HOH A . 
B 2 HOH 132 432 104 HOH HOH A . 
B 2 HOH 133 433 185 HOH HOH A . 
B 2 HOH 134 434 163 HOH HOH A . 
B 2 HOH 135 435 14  HOH HOH A . 
B 2 HOH 136 436 187 HOH HOH A . 
B 2 HOH 137 437 170 HOH HOH A . 
B 2 HOH 138 438 35  HOH HOH A . 
B 2 HOH 139 439 11  HOH HOH A . 
B 2 HOH 140 440 3   HOH HOH A . 
B 2 HOH 141 441 86  HOH HOH A . 
B 2 HOH 142 442 103 HOH HOH A . 
B 2 HOH 143 443 176 HOH HOH A . 
B 2 HOH 144 444 197 HOH HOH A . 
B 2 HOH 145 445 96  HOH HOH A . 
B 2 HOH 146 446 180 HOH HOH A . 
B 2 HOH 147 447 120 HOH HOH A . 
B 2 HOH 148 448 168 HOH HOH A . 
B 2 HOH 149 449 192 HOH HOH A . 
B 2 HOH 150 450 130 HOH HOH A . 
B 2 HOH 151 451 173 HOH HOH A . 
B 2 HOH 152 452 18  HOH HOH A . 
B 2 HOH 153 453 55  HOH HOH A . 
B 2 HOH 154 454 90  HOH HOH A . 
B 2 HOH 155 455 117 HOH HOH A . 
B 2 HOH 156 456 39  HOH HOH A . 
B 2 HOH 157 457 169 HOH HOH A . 
B 2 HOH 158 458 172 HOH HOH A . 
B 2 HOH 159 459 190 HOH HOH A . 
B 2 HOH 160 460 53  HOH HOH A . 
B 2 HOH 161 461 196 HOH HOH A . 
B 2 HOH 162 462 44  HOH HOH A . 
B 2 HOH 163 463 181 HOH HOH A . 
B 2 HOH 164 464 193 HOH HOH A . 
B 2 HOH 165 465 126 HOH HOH A . 
B 2 HOH 166 466 82  HOH HOH A . 
B 2 HOH 167 467 64  HOH HOH A . 
B 2 HOH 168 468 60  HOH HOH A . 
B 2 HOH 169 469 175 HOH HOH A . 
B 2 HOH 170 470 160 HOH HOH A . 
B 2 HOH 171 471 114 HOH HOH A . 
B 2 HOH 172 472 78  HOH HOH A . 
B 2 HOH 173 473 42  HOH HOH A . 
B 2 HOH 174 474 105 HOH HOH A . 
B 2 HOH 175 475 75  HOH HOH A . 
B 2 HOH 176 476 102 HOH HOH A . 
B 2 HOH 177 477 171 HOH HOH A . 
B 2 HOH 178 478 79  HOH HOH A . 
B 2 HOH 179 479 50  HOH HOH A . 
B 2 HOH 180 480 119 HOH HOH A . 
B 2 HOH 181 481 134 HOH HOH A . 
B 2 HOH 182 482 99  HOH HOH A . 
B 2 HOH 183 483 69  HOH HOH A . 
B 2 HOH 184 484 85  HOH HOH A . 
B 2 HOH 185 485 182 HOH HOH A . 
B 2 HOH 186 486 189 HOH HOH A . 
B 2 HOH 187 487 71  HOH HOH A . 
B 2 HOH 188 488 184 HOH HOH A . 
B 2 HOH 189 489 167 HOH HOH A . 
B 2 HOH 190 490 135 HOH HOH A . 
B 2 HOH 191 491 183 HOH HOH A . 
B 2 HOH 192 492 147 HOH HOH A . 
B 2 HOH 193 493 38  HOH HOH A . 
B 2 HOH 194 494 106 HOH HOH A . 
B 2 HOH 195 495 132 HOH HOH A . 
B 2 HOH 196 496 194 HOH HOH A . 
B 2 HOH 197 497 188 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A ARG 178 ? NE  ? A ARG 179 NE  
2 1 Y 1 A ARG 178 ? CZ  ? A ARG 179 CZ  
3 1 Y 1 A ARG 178 ? NH1 ? A ARG 179 NH1 
4 1 Y 1 A ARG 178 ? NH2 ? A ARG 179 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9F7J 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     51.745 
_cell.length_a_esd                 ? 
_cell.length_b                     60.353 
_cell.length_b_esd                 ? 
_cell.length_c                     134.514 
_cell.length_c_esd                 ? 
_cell.volume                       420082.647 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9F7J 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            'C 2c 2' 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9F7J 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.22 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          44.49 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '18% PEG3350, 0.1 M sodium acetate pH 4.5, 0.1 M Bis-Tris pH 5.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            297 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-05-29 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.033200 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PETRA III, DESY BEAMLINE P11' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.033200 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   P11 
_diffrn_source.pdbx_synchrotron_site       'PETRA III, DESY' 
# 
_reflns.B_iso_Wilson_estimate                          22.81 
_reflns.entry_id                                       9F7J 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.72 
_reflns.d_resolution_low                               39.28 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     22757 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.78 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.13 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.0498 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.175 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.72 
_reflns_shell.d_res_low                                     1.781 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2228 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.5617 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.774 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  2.034 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.32 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9F7J 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.72 
_refine.ls_d_res_low                             39.28 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22751 
_refine.ls_number_reflns_R_free                  1939 
_refine.ls_number_reflns_R_work                  39448 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.81 
_refine.ls_percent_reflns_R_free                 8.56 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1805 
_refine.ls_R_factor_R_free                       0.2092 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1778 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.6713 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2100 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.72 
_refine_hist.d_res_low                        39.28 
_refine_hist.number_atoms_solvent             197 
_refine_hist.number_atoms_total               1744 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1547 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0063 ? 1602 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8731 ? 2188 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0558 ? 264  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0105 ? 279  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.5820 ? 216  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.72 1.74  . . 139 1486 99.69  . . . . 0.2931 . . . . . . . . . . . 0.3240 
'X-RAY DIFFRACTION' 1.74 1.77  . . 139 1496 99.94  . . . . 0.2735 . . . . . . . . . . . 0.2912 
'X-RAY DIFFRACTION' 1.77 1.79  . . 147 1555 99.88  . . . . 0.2871 . . . . . . . . . . . 0.3108 
'X-RAY DIFFRACTION' 1.79 1.82  . . 147 1537 99.70  . . . . 0.2541 . . . . . . . . . . . 0.2891 
'X-RAY DIFFRACTION' 1.82 1.85  . . 136 1503 99.88  . . . . 0.2393 . . . . . . . . . . . 0.2916 
'X-RAY DIFFRACTION' 1.85 1.88  . . 140 1518 99.88  . . . . 0.2337 . . . . . . . . . . . 0.2466 
'X-RAY DIFFRACTION' 1.88 1.91  . . 138 1509 99.76  . . . . 0.2296 . . . . . . . . . . . 0.2532 
'X-RAY DIFFRACTION' 1.91 1.94  . . 142 1505 99.88  . . . . 0.2180 . . . . . . . . . . . 0.2665 
'X-RAY DIFFRACTION' 1.94 1.98  . . 150 1560 99.94  . . . . 0.2074 . . . . . . . . . . . 0.2797 
'X-RAY DIFFRACTION' 1.98 2.02  . . 139 1473 100.00 . . . . 0.1976 . . . . . . . . . . . 0.2454 
'X-RAY DIFFRACTION' 2.02 2.07  . . 146 1544 100.00 . . . . 0.1789 . . . . . . . . . . . 0.2180 
'X-RAY DIFFRACTION' 2.07 2.11  . . 139 1499 99.88  . . . . 0.1882 . . . . . . . . . . . 0.1893 
'X-RAY DIFFRACTION' 2.11 2.17  . . 142 1511 99.04  . . . . 0.1686 . . . . . . . . . . . 0.2074 
'X-RAY DIFFRACTION' 2.17 2.23  . . 145 1540 99.94  . . . . 0.1680 . . . . . . . . . . . 0.1929 
'X-RAY DIFFRACTION' 2.23 2.29  . . 140 1501 100.00 . . . . 0.1552 . . . . . . . . . . . 0.1941 
'X-RAY DIFFRACTION' 2.29 2.36  . . 146 1524 99.82  . . . . 0.1642 . . . . . . . . . . . 0.2270 
'X-RAY DIFFRACTION' 2.37 2.45  . . 140 1521 100.00 . . . . 0.1677 . . . . . . . . . . . 0.1990 
'X-RAY DIFFRACTION' 2.45 2.55  . . 145 1498 100.00 . . . . 0.1719 . . . . . . . . . . . 0.1960 
'X-RAY DIFFRACTION' 2.55 2.66  . . 140 1535 100.00 . . . . 0.1741 . . . . . . . . . . . 0.2428 
'X-RAY DIFFRACTION' 2.66 2.80  . . 140 1519 100.00 . . . . 0.1751 . . . . . . . . . . . 0.1977 
'X-RAY DIFFRACTION' 2.80 2.98  . . 144 1527 100.00 . . . . 0.1738 . . . . . . . . . . . 0.2061 
'X-RAY DIFFRACTION' 2.98 3.21  . . 140 1522 100.00 . . . . 0.1704 . . . . . . . . . . . 0.2045 
'X-RAY DIFFRACTION' 3.21 3.53  . . 137 1515 100.00 . . . . 0.1659 . . . . . . . . . . . 0.1750 
'X-RAY DIFFRACTION' 3.53 4.04  . . 144 1505 98.86  . . . . 0.1506 . . . . . . . . . . . 0.1646 
'X-RAY DIFFRACTION' 4.04 5.09  . . 141 1524 99.82  . . . . 0.1533 . . . . . . . . . . . 0.1954 
'X-RAY DIFFRACTION' 5.09 39.28 . . 145 1521 99.70  . . . . 0.1831 . . . . . . . . . . . 0.2132 
# 
_struct.entry_id                     9F7J 
_struct.title                        'Rhodococcus diDNase in apo state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9F7J 
_struct_keywords.text            'DNase DEDDy family Dinuclease, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    9F7J 
_struct_ref.pdbx_db_accession          9F7J 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9F7J 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 214 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             9F7J 
_struct_ref_seq.db_align_beg                  0 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  213 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       0 
_struct_ref_seq.pdbx_auth_seq_align_end       213 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2410  ? 
1 MORE         -26   ? 
1 'SSA (A^2)'  18430 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'light scattering' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z         1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000   
2 'crystal symmetry operation' 3_654 -x+1,y,-z-1/2 -1.0000000000 0.0000000000 0.0000000000 51.7450000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 -67.2570000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 SER A 20  ? GLY A 31  ? SER A 19  GLY A 30  1 ? 12 
HELX_P HELX_P2 AA2 PRO A 72  ? ALA A 81  ? PRO A 71  ALA A 80  1 ? 10 
HELX_P HELX_P3 AA3 HIS A 90  ? GLN A 103 ? HIS A 89  GLN A 102 1 ? 14 
HELX_P HELX_P4 AA4 SER A 112 ? TRP A 120 ? SER A 111 TRP A 119 1 ? 9  
HELX_P HELX_P5 AA5 LYS A 124 ? GLN A 127 ? LYS A 123 GLN A 126 5 ? 4  
HELX_P HELX_P6 AA6 SER A 128 ? GLY A 138 ? SER A 127 GLY A 137 1 ? 11 
HELX_P HELX_P7 AA7 THR A 156 ? ARG A 184 ? THR A 155 ARG A 183 1 ? 29 
HELX_P HELX_P8 AA8 LEU A 186 ? HIS A 206 ? LEU A 185 HIS A 205 1 ? 21 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   6 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 12  ? ASP A 16  ? VAL A 11  ASP A 15  
AA1 2 GLY A 60  ? ARG A 65  ? GLY A 59  ARG A 64  
AA1 3 LEU A 49  ? VAL A 56  ? LEU A 48  VAL A 55  
AA1 4 ARG A 32  ? THR A 39  ? ARG A 31  THR A 38  
AA1 5 VAL A 85  ? PHE A 88  ? VAL A 84  PHE A 87  
AA1 6 VAL A 109 ? CYS A 111 ? VAL A 108 CYS A 110 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ARG A 15 ? N ARG A 14 O ARG A 65  ? O ARG A 64  
AA1 2 3 O VAL A 64 ? O VAL A 63 N VAL A 52  ? N VAL A 51  
AA1 3 4 O GLN A 53 ? O GLN A 52 N ASP A 36  ? N ASP A 35  
AA1 4 5 N VAL A 33 ? N VAL A 32 O GLY A 87  ? O GLY A 86  
AA1 5 6 N LYS A 86 ? N LYS A 85 O VAL A 110 ? O VAL A 109 
# 
_pdbx_entry_details.entry_id                   9F7J 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 470 ? ? O A HOH 489 ? ? 1.89 
2 1 O   A HOH 446 ? ? O A HOH 448 ? ? 1.97 
3 1 O   A HOH 443 ? ? O A HOH 485 ? ? 2.02 
4 1 O   A HOH 421 ? ? O A HOH 482 ? ? 2.04 
5 1 O   A HOH 354 ? ? O A HOH 414 ? ? 2.10 
6 1 O   A HOH 446 ? ? O A HOH 469 ? ? 2.14 
7 1 NH2 A ARG 64  ? ? O A GLN 151 ? ? 2.15 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     418 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     418 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   4_555 
_pdbx_validate_symm_contact.dist              2.13 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    HIS 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     89 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             -158.98 
_pdbx_validate_torsion.psi             75.29 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 422 ? B HOH . 
2 1 A HOH 483 ? B HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 x,-y,-z             
3 -x,y,-z+1/2         
4 -x,-y,z+1/2         
5 x+1/2,y+1/2,z       
6 x+1/2,-y+1/2,-z     
7 -x+1/2,y+1/2,-z+1/2 
8 -x+1/2,-y+1/2,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A SER 0   ? A SER 1   
2  1 Y 1 A MET 1   ? A MET 2   
3  1 Y 1 A LYS 2   ? A LYS 3   
4  1 Y 1 A LYS 3   ? A LYS 4   
5  1 Y 1 A ILE 4   ? A ILE 5   
6  1 Y 1 A ASP 5   ? A ASP 6   
7  1 Y 1 A PRO 6   ? A PRO 7   
8  1 Y 1 A LEU 7   ? A LEU 8   
9  1 Y 1 A ALA 8   ? A ALA 9   
10 1 Y 1 A SER 9   ? A SER 10  
11 1 Y 1 A LYS 142 ? A LYS 143 
12 1 Y 1 A THR 143 ? A THR 144 
13 1 Y 1 A PRO 144 ? A PRO 145 
14 1 Y 1 A ARG 145 ? A ARG 146 
15 1 Y 1 A LEU 146 ? A LEU 147 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'National Institutes of Health/National Cancer Institute (NIH/NCI)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           R01GM123609 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7MPL 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 2 2 21' 
_space_group.name_Hall        'C 2c 2' 
_space_group.IT_number        20 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9F7J 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.019326 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016569 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007434 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . THR A 1 11  ? 2.35898  1.51706   -5.14802  1.000 53.60349 ? 10  THR A N   1 
ATOM   2    C CA  . THR A 1 11  ? 2.76863  1.52234   -6.55085  1.000 34.18030 ? 10  THR A CA  1 
ATOM   3    C C   . THR A 1 11  ? 4.07179  2.30867   -6.76080  1.000 38.67371 ? 10  THR A C   1 
ATOM   4    O O   . THR A 1 11  ? 4.71963  2.17369   -7.81120  1.000 30.09351 ? 10  THR A O   1 
ATOM   5    C CB  . THR A 1 11  ? 1.66267  2.11625   -7.45186  1.000 40.15383 ? 10  THR A CB  1 
ATOM   6    O OG1 . THR A 1 11  ? 2.19619  2.42418   -8.73888  1.000 54.99615 ? 10  THR A OG1 1 
ATOM   7    C CG2 . THR A 1 11  ? 1.09413  3.39065   -6.83305  1.000 55.21768 ? 10  THR A CG2 1 
ATOM   8    N N   . VAL A 1 12  ? 4.43804  3.13505   -5.77470  1.000 30.71247 ? 11  VAL A N   1 
ATOM   9    C CA  . VAL A 1 12  ? 5.68329  3.90215   -5.77929  1.000 26.99558 ? 11  VAL A CA  1 
ATOM   10   C C   . VAL A 1 12  ? 6.36217  3.71870   -4.43112  1.000 31.94602 ? 11  VAL A C   1 
ATOM   11   O O   . VAL A 1 12  ? 5.72646  3.89679   -3.38784  1.000 30.41633 ? 11  VAL A O   1 
ATOM   12   C CB  . VAL A 1 12  ? 5.45081  5.40272   -6.04599  1.000 26.62376 ? 11  VAL A CB  1 
ATOM   13   C CG1 . VAL A 1 12  ? 6.77546  6.11431   -6.25837  1.000 28.06741 ? 11  VAL A CG1 1 
ATOM   14   C CG2 . VAL A 1 12  ? 4.53935  5.60856   -7.25440  1.000 35.05127 ? 11  VAL A CG2 1 
ATOM   15   N N   . VAL A 1 13  ? 7.65171  3.38642   -4.44832  1.000 24.35340 ? 12  VAL A N   1 
ATOM   16   C CA  . VAL A 1 13  ? 8.41462  3.16828   -3.22720  1.000 21.89636 ? 12  VAL A CA  1 
ATOM   17   C C   . VAL A 1 13  ? 9.71189  3.95499   -3.35048  1.000 20.59483 ? 12  VAL A C   1 
ATOM   18   O O   . VAL A 1 13  ? 10.39150 3.88283   -4.38134  1.000 21.53405 ? 12  VAL A O   1 
ATOM   19   C CB  . VAL A 1 13  ? 8.69862  1.67245   -2.97674  1.000 25.45365 ? 12  VAL A CB  1 
ATOM   20   C CG1 . VAL A 1 13  ? 9.82566  1.48882   -1.93856  1.000 26.10945 ? 12  VAL A CG1 1 
ATOM   21   C CG2 . VAL A 1 13  ? 7.43007  0.94720   -2.55012  1.000 33.63895 ? 12  VAL A CG2 1 
ATOM   22   N N   . VAL A 1 14  ? 10.03488 4.73130   -2.32132  1.000 17.83425 ? 13  VAL A N   1 
ATOM   23   C CA  . VAL A 1 14  ? 11.28651 5.47467   -2.29351  1.000 18.81988 ? 13  VAL A CA  1 
ATOM   24   C C   . VAL A 1 14  ? 12.36684 4.56149   -1.73766  1.000 23.32176 ? 13  VAL A C   1 
ATOM   25   O O   . VAL A 1 14  ? 12.24619 4.04195   -0.62053  1.000 21.62654 ? 13  VAL A O   1 
ATOM   26   C CB  . VAL A 1 14  ? 11.16010 6.75699   -1.46447  1.000 21.20076 ? 13  VAL A CB  1 
ATOM   27   C CG1 . VAL A 1 14  ? 12.51720 7.44430   -1.32792  1.000 21.06490 ? 13  VAL A CG1 1 
ATOM   28   C CG2 . VAL A 1 14  ? 10.13144 7.67729   -2.11077  1.000 21.90397 ? 13  VAL A CG2 1 
ATOM   29   N N   . ARG A 1 15  ? 13.42707 4.36784   -2.51251  1.000 18.03788 ? 14  ARG A N   1 
ATOM   30   C CA  . ARG A 1 15  ? 14.51763 3.49224   -2.11583  1.000 19.62304 ? 14  ARG A CA  1 
ATOM   31   C C   . ARG A 1 15  ? 15.77105 4.30284   -1.85618  1.000 21.11330 ? 14  ARG A C   1 
ATOM   32   O O   . ARG A 1 15  ? 16.05201 5.27875   -2.55642  1.000 22.95239 ? 14  ARG A O   1 
ATOM   33   C CB  . ARG A 1 15  ? 14.79189 2.42265   -3.18170  1.000 19.26638 ? 14  ARG A CB  1 
ATOM   34   C CG  . ARG A 1 15  ? 13.56021 1.62885   -3.46075  1.000 24.29390 ? 14  ARG A CG  1 
ATOM   35   C CD  . ARG A 1 15  ? 13.70865 0.20545   -2.97842  1.000 27.60720 ? 14  ARG A CD  1 
ATOM   36   N NE  . ARG A 1 15  ? 12.43690 -0.50351  -3.03010  1.000 18.75694 ? 14  ARG A NE  1 
ATOM   37   C CZ  . ARG A 1 15  ? 11.99798 -1.36323  -2.12474  1.000 26.45464 ? 14  ARG A CZ  1 
ATOM   38   N NH1 . ARG A 1 15  ? 12.72314 -1.68570  -1.06084  1.000 22.02474 ? 14  ARG A NH1 1 
ATOM   39   N NH2 . ARG A 1 15  ? 10.82314 -1.95345  -2.32003  1.000 24.67128 ? 14  ARG A NH2 1 
ATOM   40   N N   . ASP A 1 16  ? 16.52690 3.89081   -0.84602  1.000 16.74254 ? 15  ASP A N   1 
ATOM   41   C CA  . ASP A 1 16  ? 17.76525 4.56087   -0.50966  1.000 17.74363 ? 15  ASP A CA  1 
ATOM   42   C C   . ASP A 1 16  ? 18.93300 3.84650   -1.17781  1.000 23.45968 ? 15  ASP A C   1 
ATOM   43   O O   . ASP A 1 16  ? 19.13297 2.64158   -0.97896  1.000 25.54108 ? 15  ASP A O   1 
ATOM   44   C CB  . ASP A 1 16  ? 17.95113 4.57188   1.00274   1.000 22.06886 ? 15  ASP A CB  1 
ATOM   45   C CG  . ASP A 1 16  ? 16.97165 5.47472   1.68619   1.000 27.09205 ? 15  ASP A CG  1 
ATOM   46   O OD1 . ASP A 1 16  ? 17.14731 6.70206   1.56697   1.000 33.05799 ? 15  ASP A OD1 1 
ATOM   47   O OD2 . ASP A 1 16  ? 16.03358 4.96104   2.35096   1.000 27.74370 ? 15  ASP A OD2 1 
ATOM   48   N N   . GLY A 1 17  ? 19.70962 4.58743   -1.95195  1.000 20.06657 ? 16  GLY A N   1 
ATOM   49   C CA  . GLY A 1 17  ? 20.98052 4.09843   -2.42408  1.000 20.24025 ? 16  GLY A CA  1 
ATOM   50   C C   . GLY A 1 17  ? 20.96683 3.27312   -3.70201  1.000 23.12921 ? 16  GLY A C   1 
ATOM   51   O O   . GLY A 1 17  ? 21.89002 3.40158   -4.50086  1.000 22.45892 ? 16  GLY A O   1 
ATOM   52   N N   . ASP A 1 18  ? 19.96042 2.41725   -3.89967  1.000 20.75973 ? 17  ASP A N   1 
ATOM   53   C CA  . ASP A 1 18  ? 19.96394 1.50580   -5.04082  1.000 20.48864 ? 17  ASP A CA  1 
ATOM   54   C C   . ASP A 1 18  ? 18.54642 1.04344   -5.34519  1.000 20.33248 ? 17  ASP A C   1 
ATOM   55   O O   . ASP A 1 18  ? 17.65009 1.08445   -4.49624  1.000 17.89046 ? 17  ASP A O   1 
ATOM   56   C CB  . ASP A 1 18  ? 20.86047 0.28102   -4.79025  1.000 22.60103 ? 17  ASP A CB  1 
ATOM   57   C CG  . ASP A 1 18  ? 21.22449 -0.46946  -6.08377  1.000 25.24576 ? 17  ASP A CG  1 
ATOM   58   O OD1 . ASP A 1 18  ? 21.91513 -1.51347  -5.99224  1.000 23.74465 ? 17  ASP A OD1 1 
ATOM   59   O OD2 . ASP A 1 18  ? 20.85457 0.00121   -7.18890  1.000 21.48476 ? 17  ASP A OD2 1 
ATOM   60   N N   . LEU A 1 19  ? 18.35900 0.62898   -6.59429  1.000 17.50194 ? 18  LEU A N   1 
ATOM   61   C CA  . LEU A 1 19  ? 17.19700 -0.15188  -6.98788  1.000 17.40976 ? 18  LEU A CA  1 
ATOM   62   C C   . LEU A 1 19  ? 17.09542 -1.40019  -6.11924  1.000 17.70662 ? 18  LEU A C   1 
ATOM   63   O O   . LEU A 1 19  ? 18.11078 -1.96807  -5.70827  1.000 18.57469 ? 18  LEU A O   1 
ATOM   64   C CB  . LEU A 1 19  ? 17.34179 -0.55506  -8.45924  1.000 17.21335 ? 18  LEU A CB  1 
ATOM   65   C CG  . LEU A 1 19  ? 16.11186 -1.02109  -9.22056  1.000 21.90021 ? 18  LEU A CG  1 
ATOM   66   C CD1 . LEU A 1 19  ? 15.16615 0.14717   -9.49162  1.000 22.02771 ? 18  LEU A CD1 1 
ATOM   67   C CD2 . LEU A 1 19  ? 16.55007 -1.71195  -10.51934 1.000 23.50234 ? 18  LEU A CD2 1 
ATOM   68   N N   . SER A 1 20  ? 15.86169 -1.81562  -5.82139  1.000 15.25114 ? 19  SER A N   1 
ATOM   69   C CA  . SER A 1 20  ? 15.65772 -3.02052  -5.02188  1.000 19.75652 ? 19  SER A CA  1 
ATOM   70   C C   . SER A 1 20  ? 15.94842 -4.27458  -5.84323  1.000 21.43847 ? 19  SER A C   1 
ATOM   71   O O   . SER A 1 20  ? 15.90101 -4.27430  -7.07964  1.000 19.46267 ? 19  SER A O   1 
ATOM   72   C CB  . SER A 1 20  ? 14.22470 -3.09815  -4.47922  1.000 18.81761 ? 19  SER A CB  1 
ATOM   73   O OG  . SER A 1 20  ? 13.26905 -3.28760  -5.52985  1.000 20.78306 ? 19  SER A OG  1 
ATOM   74   N N   . SER A 1 21  ? 16.25798 -5.36159  -5.13421  1.000 17.97714 ? 20  SER A N   1 
ATOM   75   C CA  . SER A 1 21  ? 16.42164 -6.64117  -5.81577  1.000 22.83494 ? 20  SER A CA  1 
ATOM   76   C C   . SER A 1 21  ? 15.12548 -7.07927  -6.49221  1.000 24.31347 ? 20  SER A C   1 
ATOM   77   O O   . SER A 1 21  ? 15.15822 -7.68584  -7.57002  1.000 21.87497 ? 20  SER A O   1 
ATOM   78   C CB  . SER A 1 21  ? 16.93328 -7.70337  -4.83288  1.000 24.75516 ? 20  SER A CB  1 
ATOM   79   O OG  . SER A 1 21  ? 15.99010 -7.96587  -3.80591  1.000 37.47942 ? 20  SER A OG  1 
ATOM   80   N N   . SER A 1 22  ? 13.97718 -6.73553  -5.91032  1.000 23.53303 ? 21  SER A N   1 
ATOM   81   C CA  A SER A 1 22  ? 12.70983 -7.11495  -6.51991  0.550 22.10093 ? 21  SER A CA  1 
ATOM   82   C CA  B SER A 1 22  ? 12.70139 -7.10025  -6.51534  0.450 22.13480 ? 21  SER A CA  1 
ATOM   83   C C   . SER A 1 22  ? 12.50007 -6.38735  -7.84516  1.000 25.15400 ? 21  SER A C   1 
ATOM   84   O O   . SER A 1 22  ? 11.97755 -6.97258  -8.80158  1.000 22.25810 ? 21  SER A O   1 
ATOM   85   C CB  A SER A 1 22  ? 11.56067 -6.83689  -5.54607  0.550 29.12754 ? 21  SER A CB  1 
ATOM   86   C CB  B SER A 1 22  ? 11.55632 -6.77534  -5.55449  0.450 29.08284 ? 21  SER A CB  1 
ATOM   87   O OG  A SER A 1 22  ? 10.33915 -6.57182  -6.21185  0.550 25.15033 ? 21  SER A OG  1 
ATOM   88   O OG  B SER A 1 22  ? 11.46824 -5.37970  -5.31697  0.450 23.60253 ? 21  SER A OG  1 
ATOM   89   N N   . PHE A 1 23  ? 12.90324 -5.11672  -7.92632  1.000 20.07512 ? 22  PHE A N   1 
ATOM   90   C CA  . PHE A 1 23  ? 12.72093 -4.39392  -9.17733  1.000 20.47383 ? 22  PHE A CA  1 
ATOM   91   C C   . PHE A 1 23  ? 13.75525 -4.80399  -10.20972 1.000 18.16662 ? 22  PHE A C   1 
ATOM   92   O O   . PHE A 1 23  ? 13.46023 -4.78038  -11.40723 1.000 20.96519 ? 22  PHE A O   1 
ATOM   93   C CB  . PHE A 1 23  ? 12.76029 -2.88352  -8.93826  1.000 21.07181 ? 22  PHE A CB  1 
ATOM   94   C CG  . PHE A 1 23  ? 11.39239 -2.24664  -8.99942  1.000 24.92750 ? 22  PHE A CG  1 
ATOM   95   C CD1 . PHE A 1 23  ? 10.37741 -2.72127  -8.16850  1.000 21.76240 ? 22  PHE A CD1 1 
ATOM   96   C CD2 . PHE A 1 23  ? 11.10824 -1.21955  -9.88409  1.000 24.84652 ? 22  PHE A CD2 1 
ATOM   97   C CE1 . PHE A 1 23  ? 9.10942  -2.16756  -8.20310  1.000 27.16867 ? 22  PHE A CE1 1 
ATOM   98   C CE2 . PHE A 1 23  ? 9.83236  -0.65634  -9.93166  1.000 23.35981 ? 22  PHE A CE2 1 
ATOM   99   C CZ  . PHE A 1 23  ? 8.82921  -1.13417  -9.09078  1.000 25.50794 ? 22  PHE A CZ  1 
ATOM   100  N N   . LEU A 1 24  ? 14.95779 -5.18953  -9.77798  1.000 17.96298 ? 23  LEU A N   1 
ATOM   101  C CA  . LEU A 1 24  ? 15.92444 -5.75259  -10.72210 1.000 20.76063 ? 23  LEU A CA  1 
ATOM   102  C C   . LEU A 1 24  ? 15.35805 -6.99991  -11.39246 1.000 21.27158 ? 23  LEU A C   1 
ATOM   103  O O   . LEU A 1 24  ? 15.43323 -7.15404  -12.61643 1.000 20.04138 ? 23  LEU A O   1 
ATOM   104  C CB  . LEU A 1 24  ? 17.23872 -6.07738  -10.00781 1.000 22.53063 ? 23  LEU A CB  1 
ATOM   105  C CG  . LEU A 1 24  ? 18.30758 -6.81291  -10.83390 1.000 23.13710 ? 23  LEU A CG  1 
ATOM   106  C CD1 . LEU A 1 24  ? 18.63062 -6.03293  -12.11204 1.000 21.88973 ? 23  LEU A CD1 1 
ATOM   107  C CD2 . LEU A 1 24  ? 19.58431 -7.05959  -10.02294 1.000 22.70321 ? 23  LEU A CD2 1 
ATOM   108  N N   . ALA A 1 25  ? 14.79385 -7.91323  -10.59707 1.000 21.91991 ? 24  ALA A N   1 
ATOM   109  C CA  . ALA A 1 25  ? 14.16189 -9.09861  -11.17606 1.000 25.30160 ? 24  ALA A CA  1 
ATOM   110  C C   . ALA A 1 25  ? 12.98020 -8.72511  -12.06287 1.000 22.81277 ? 24  ALA A C   1 
ATOM   111  O O   . ALA A 1 25  ? 12.78679 -9.31395  -13.13237 1.000 22.90672 ? 24  ALA A O   1 
ATOM   112  C CB  . ALA A 1 25  ? 13.70636 -10.05050 -10.07264 1.000 22.46652 ? 24  ALA A CB  1 
ATOM   113  N N   . ALA A 1 26  ? 12.16539 -7.76450  -11.63057 1.000 18.83160 ? 25  ALA A N   1 
ATOM   114  C CA  . ALA A 1 26  ? 11.01241 -7.37736  -12.43440 1.000 20.67924 ? 25  ALA A CA  1 
ATOM   115  C C   . ALA A 1 26  ? 11.44715 -6.74431  -13.75257 1.000 22.02633 ? 25  ALA A C   1 
ATOM   116  O O   . ALA A 1 26  ? 10.81476 -6.97367  -14.79174 1.000 21.62261 ? 25  ALA A O   1 
ATOM   117  C CB  . ALA A 1 26  ? 10.11400 -6.42267  -11.66017 1.000 19.80192 ? 25  ALA A CB  1 
ATOM   118  N N   . ALA A 1 27  ? 12.50485 -5.92346  -13.71859 1.000 20.06938 ? 26  ALA A N   1 
ATOM   119  C CA  . ALA A 1 27  ? 13.04811 -5.34976  -14.94950 1.000 18.55075 ? 26  ALA A CA  1 
ATOM   120  C C   . ALA A 1 27  ? 13.53791 -6.44091  -15.88964 1.000 21.51419 ? 26  ALA A C   1 
ATOM   121  O O   . ALA A 1 27  ? 13.30206 -6.38074  -17.10189 1.000 24.55704 ? 26  ALA A O   1 
ATOM   122  C CB  . ALA A 1 27  ? 14.18910 -4.38225  -14.62908 1.000 18.83390 ? 26  ALA A CB  1 
ATOM   123  N N   . ARG A 1 28  ? 14.22835 -7.44459  -15.34660 1.000 19.45347 ? 27  ARG A N   1 
ATOM   124  C CA  . ARG A 1 28  ? 14.71804 -8.54081  -16.17397 1.000 23.51115 ? 27  ARG A CA  1 
ATOM   125  C C   . ARG A 1 28  ? 13.57274 -9.31948  -16.80635 1.000 23.91552 ? 27  ARG A C   1 
ATOM   126  O O   . ARG A 1 28  ? 13.65629 -9.70909  -17.98222 1.000 25.99163 ? 27  ARG A O   1 
ATOM   127  C CB  . ARG A 1 28  ? 15.59753 -9.46384  -15.33718 1.000 22.47399 ? 27  ARG A CB  1 
ATOM   128  C CG  . ARG A 1 28  ? 16.97901 -8.88986  -15.08473 1.000 26.56215 ? 27  ARG A CG  1 
ATOM   129  C CD  . ARG A 1 28  ? 17.81545 -9.76930  -14.16386 1.000 30.18940 ? 27  ARG A CD  1 
ATOM   130  N NE  . ARG A 1 28  ? 19.19158 -9.29245  -14.13288 1.000 32.11927 ? 27  ARG A NE  1 
ATOM   131  C CZ  . ARG A 1 28  ? 20.02201 -9.41533  -13.10691 1.000 36.57382 ? 27  ARG A CZ  1 
ATOM   132  N NH1 . ARG A 1 28  ? 19.64335 -9.98622  -11.97146 1.000 41.70045 ? 27  ARG A NH1 1 
ATOM   133  N NH2 . ARG A 1 28  ? 21.26047 -8.93901  -13.21867 1.000 40.09199 ? 27  ARG A NH2 1 
ATOM   134  N N   . GLN A 1 29  ? 12.49615 -9.55783  -16.04763 1.000 21.98958 ? 28  GLN A N   1 
ATOM   135  C CA  . GLN A 1 29  ? 11.33870 -10.26517 -16.59765 1.000 24.48241 ? 28  GLN A CA  1 
ATOM   136  C C   . GLN A 1 29  ? 10.65357 -9.44860  -17.69172 1.000 27.46218 ? 28  GLN A C   1 
ATOM   137  O O   . GLN A 1 29  ? 10.29113 -9.98574  -18.74817 1.000 30.80636 ? 28  GLN A O   1 
ATOM   138  C CB  . GLN A 1 29  ? 10.33315 -10.59682 -15.49157 1.000 24.39831 ? 28  GLN A CB  1 
ATOM   139  C CG  . GLN A 1 29  ? 9.02684  -11.19289 -16.05890 1.000 27.61231 ? 28  GLN A CG  1 
ATOM   140  C CD  . GLN A 1 29  ? 8.03285  -11.61813 -14.99296 1.000 30.99292 ? 28  GLN A CD  1 
ATOM   141  O OE1 . GLN A 1 29  ? 8.34352  -12.44285 -14.13176 1.000 35.04797 ? 28  GLN A OE1 1 
ATOM   142  N NE2 . GLN A 1 29  ? 6.82074  -11.07502 -15.06260 1.000 28.82192 ? 28  GLN A NE2 1 
ATOM   143  N N   . CYS A 1 30  ? 10.43608 -8.15299  -17.43654 1.000 23.86602 ? 29  CYS A N   1 
ATOM   144  C CA  . CYS A 1 30  ? 9.79372  -7.26739  -18.40801 1.000 22.72504 ? 29  CYS A CA  1 
ATOM   145  C C   . CYS A 1 30  ? 10.60532 -7.13595  -19.68660 1.000 22.90453 ? 29  CYS A C   1 
ATOM   146  O O   . CYS A 1 30  ? 10.04514 -7.13963  -20.78897 1.000 23.02319 ? 29  CYS A O   1 
ATOM   147  C CB  . CYS A 1 30  ? 9.58073  -5.86707  -17.82139 1.000 23.36217 ? 29  CYS A CB  1 
ATOM   148  S SG  . CYS A 1 30  ? 8.29446  -4.89624  -18.71525 1.000 36.56753 ? 29  CYS A SG  1 
ATOM   149  N N   . GLY A 1 31  ? 11.91505 -6.94940  -19.55162 1.000 22.72196 ? 30  GLY A N   1 
ATOM   150  C CA  . GLY A 1 31  ? 12.78323 -6.61112  -20.66173 1.000 24.03690 ? 30  GLY A CA  1 
ATOM   151  C C   . GLY A 1 31  ? 12.75332 -5.15658  -21.07595 1.000 26.36877 ? 30  GLY A C   1 
ATOM   152  O O   . GLY A 1 31  ? 13.46170 -4.78976  -22.02525 1.000 23.30594 ? 30  GLY A O   1 
ATOM   153  N N   . ARG A 1 32  ? 11.96386 -4.32278  -20.39386 1.000 21.32691 ? 31  ARG A N   1 
ATOM   154  C CA  . ARG A 1 32  ? 11.76044 -2.92400  -20.74960 1.000 21.51574 ? 31  ARG A CA  1 
ATOM   155  C C   . ARG A 1 32  ? 11.48478 -2.14973  -19.47234 1.000 26.76813 ? 31  ARG A C   1 
ATOM   156  O O   . ARG A 1 32  ? 10.67754 -2.60000  -18.65810 1.000 25.67002 ? 31  ARG A O   1 
ATOM   157  C CB  . ARG A 1 32  ? 10.56573 -2.77758  -21.69388 1.000 32.69241 ? 31  ARG A CB  1 
ATOM   158  C CG  . ARG A 1 32  ? 10.50281 -1.50887  -22.50298 1.000 42.92493 ? 31  ARG A CG  1 
ATOM   159  C CD  . ARG A 1 32  ? 9.38951  -1.63807  -23.53720 1.000 51.70159 ? 31  ARG A CD  1 
ATOM   160  N NE  . ARG A 1 32  ? 8.84925  -0.35176  -23.97089 1.000 59.62112 ? 31  ARG A NE  1 
ATOM   161  C CZ  . ARG A 1 32  ? 7.55734  -0.04279  -23.98878 1.000 49.97874 ? 31  ARG A CZ  1 
ATOM   162  N NH1 . ARG A 1 32  ? 6.64332  -0.85824  -23.48748 1.000 45.15836 ? 31  ARG A NH1 1 
ATOM   163  N NH2 . ARG A 1 32  ? 7.17149  1.11178   -24.52892 1.000 38.50307 ? 31  ARG A NH2 1 
ATOM   164  N N   . VAL A 1 33  ? 12.13419 -0.99417  -19.30382 1.000 18.96301 ? 32  VAL A N   1 
ATOM   165  C CA  . VAL A 1 33  ? 11.84524 -0.08310  -18.19836 1.000 16.96399 ? 32  VAL A CA  1 
ATOM   166  C C   . VAL A 1 33  ? 11.86142 1.33793   -18.73638 1.000 18.15967 ? 32  VAL A C   1 
ATOM   167  O O   . VAL A 1 33  ? 12.37394 1.60620   -19.82707 1.000 20.32521 ? 32  VAL A O   1 
ATOM   168  C CB  . VAL A 1 33  ? 12.84434 -0.19410  -17.02251 1.000 23.48006 ? 32  VAL A CB  1 
ATOM   169  C CG1 . VAL A 1 33  ? 12.95843 -1.63475  -16.51359 1.000 23.98633 ? 32  VAL A CG1 1 
ATOM   170  C CG2 . VAL A 1 33  ? 14.21548 0.33237   -17.44865 1.000 16.57476 ? 32  VAL A CG2 1 
ATOM   171  N N   . THR A 1 34  ? 11.31707 2.26119   -17.94122 1.000 15.63517 ? 33  THR A N   1 
ATOM   172  C CA  . THR A 1 34  ? 11.45815 3.67640   -18.22649 1.000 16.08047 ? 33  THR A CA  1 
ATOM   173  C C   . THR A 1 34  ? 12.13605 4.37936   -17.06069 1.000 18.76491 ? 33  THR A C   1 
ATOM   174  O O   . THR A 1 34  ? 11.99697 3.97946   -15.90322 1.000 17.11784 ? 33  THR A O   1 
ATOM   175  C CB  . THR A 1 34  ? 10.11669 4.31715   -18.54078 1.000 18.52547 ? 33  THR A CB  1 
ATOM   176  O OG1 . THR A 1 34  ? 9.16390  3.92795   -17.55018 1.000 16.94795 ? 33  THR A OG1 1 
ATOM   177  C CG2 . THR A 1 34  ? 9.64406  3.86076   -19.91318 1.000 20.42156 ? 33  THR A CG2 1 
ATOM   178  N N   . ILE A 1 35  ? 12.90597 5.41164   -17.38049 1.000 14.67303 ? 34  ILE A N   1 
ATOM   179  C CA  . ILE A 1 35  ? 13.82411 6.01590   -16.42360 1.000 17.38742 ? 34  ILE A CA  1 
ATOM   180  C C   . ILE A 1 35  ? 13.81756 7.52364   -16.61993 1.000 18.31694 ? 34  ILE A C   1 
ATOM   181  O O   . ILE A 1 35  ? 13.75776 8.01213   -17.74871 1.000 19.50973 ? 34  ILE A O   1 
ATOM   182  C CB  . ILE A 1 35  ? 15.25768 5.44284   -16.57455 1.000 21.36685 ? 34  ILE A CB  1 
ATOM   183  C CG1 . ILE A 1 35  ? 15.30763 3.98365   -16.09072 1.000 26.47210 ? 34  ILE A CG1 1 
ATOM   184  C CG2 . ILE A 1 35  ? 16.30563 6.28135   -15.79203 1.000 20.59448 ? 34  ILE A CG2 1 
ATOM   185  C CD1 . ILE A 1 35  ? 16.63510 3.29861   -16.30232 1.000 25.27758 ? 34  ILE A CD1 1 
ATOM   186  N N   . ASP A 1 36  ? 13.88320 8.26712   -15.52480 1.000 17.46959 ? 35  ASP A N   1 
ATOM   187  C CA  . ASP A 1 36  ? 14.28677 9.65923   -15.62028 1.000 19.91090 ? 35  ASP A CA  1 
ATOM   188  C C   . ASP A 1 36  ? 14.94418 10.02794  -14.29827 1.000 18.62804 ? 35  ASP A C   1 
ATOM   189  O O   . ASP A 1 36  ? 15.21501 9.15694   -13.46415 1.000 19.54223 ? 35  ASP A O   1 
ATOM   190  C CB  . ASP A 1 36  ? 13.10754 10.51745  -16.10555 1.000 27.22037 ? 35  ASP A CB  1 
ATOM   191  C CG  . ASP A 1 36  ? 12.19513 10.96807  -15.03398 1.000 29.36370 ? 35  ASP A CG  1 
ATOM   192  O OD1 . ASP A 1 36  ? 12.06708 10.28679  -14.00084 1.000 34.03509 ? 35  ASP A OD1 1 
ATOM   193  O OD2 . ASP A 1 36  ? 11.50064 11.97521  -15.30643 1.000 31.85074 ? 35  ASP A OD2 1 
ATOM   194  N N   . THR A 1 37  ? 15.28403 11.30273  -14.14014 1.000 20.76851 ? 36  THR A N   1 
ATOM   195  C CA  . THR A 1 37  ? 16.05427 11.73739  -12.98035 1.000 20.17778 ? 36  THR A CA  1 
ATOM   196  C C   . THR A 1 37  ? 15.46793 13.01949  -12.41205 1.000 26.18032 ? 36  THR A C   1 
ATOM   197  O O   . THR A 1 37  ? 14.71770 13.73244  -13.07854 1.000 25.79620 ? 36  THR A O   1 
ATOM   198  C CB  . THR A 1 37  ? 17.52214 11.98044  -13.34955 1.000 22.86591 ? 36  THR A CB  1 
ATOM   199  O OG1 . THR A 1 37  ? 17.59294 13.05782  -14.30060 1.000 23.98032 ? 36  THR A OG1 1 
ATOM   200  C CG2 . THR A 1 37  ? 18.15475 10.72372  -13.93632 1.000 20.61418 ? 36  THR A CG2 1 
ATOM   201  N N   . GLU A 1 38  ? 15.82051 13.30714  -11.16127 1.000 19.46116 ? 37  GLU A N   1 
ATOM   202  C CA  . GLU A 1 38  ? 15.68296 14.64804  -10.61834 1.000 22.44366 ? 37  GLU A CA  1 
ATOM   203  C C   . GLU A 1 38  ? 17.06245 15.14289  -10.22356 1.000 22.68845 ? 37  GLU A C   1 
ATOM   204  O O   . GLU A 1 38  ? 17.87205 14.38539  -9.67823  1.000 20.38320 ? 37  GLU A O   1 
ATOM   205  C CB  . GLU A 1 38  ? 14.70660 14.70209  -9.41355  1.000 23.43553 ? 37  GLU A CB  1 
ATOM   206  C CG  . GLU A 1 38  ? 13.40467 13.95401  -9.67606  1.000 31.21038 ? 37  GLU A CG  1 
ATOM   207  C CD  . GLU A 1 38  ? 12.42168 14.75626  -10.52882 1.000 48.41926 ? 37  GLU A CD  1 
ATOM   208  O OE1 . GLU A 1 38  ? 12.50330 16.00617  -10.52190 1.000 51.47261 ? 37  GLU A OE1 1 
ATOM   209  O OE2 . GLU A 1 38  ? 11.58473 14.13283  -11.22973 1.000 47.93478 ? 37  GLU A OE2 1 
ATOM   210  N N   . THR A 1 39  ? 17.33547 16.40909  -10.52847 1.000 22.18130 ? 38  THR A N   1 
ATOM   211  C CA  . THR A 1 39  ? 18.66304 16.98077  -10.38696 1.000 23.42795 ? 38  THR A CA  1 
ATOM   212  C C   . THR A 1 39  ? 18.55464 18.37005  -9.77845  1.000 26.30778 ? 38  THR A C   1 
ATOM   213  O O   . THR A 1 39  ? 17.48183 18.97487  -9.74510  1.000 28.62598 ? 38  THR A O   1 
ATOM   214  C CB  . THR A 1 39  ? 19.38048 17.10473  -11.73816 1.000 22.94545 ? 38  THR A CB  1 
ATOM   215  O OG1 . THR A 1 39  ? 18.66943 18.06396  -12.53107 1.000 22.88974 ? 38  THR A OG1 1 
ATOM   216  C CG2 . THR A 1 39  ? 19.42039 15.75185  -12.46150 1.000 22.24837 ? 38  THR A CG2 1 
ATOM   217  N N   . THR A 1 40  ? 19.70044 18.88849  -9.34366  1.000 26.77882 ? 39  THR A N   1 
ATOM   218  C CA  . THR A 1 40  ? 19.78045 20.23856  -8.79830  1.000 31.88924 ? 39  THR A CA  1 
ATOM   219  C C   . THR A 1 40  ? 19.89925 21.30525  -9.88006  1.000 32.90285 ? 39  THR A C   1 
ATOM   220  O O   . THR A 1 40  ? 19.76591 22.49463  -9.57458  1.000 33.57095 ? 39  THR A O   1 
ATOM   221  C CB  . THR A 1 40  ? 20.96740 20.36138  -7.83616  1.000 28.28947 ? 39  THR A CB  1 
ATOM   222  O OG1 . THR A 1 40  ? 22.19465 20.11511  -8.53119  1.000 31.32824 ? 39  THR A OG1 1 
ATOM   223  C CG2 . THR A 1 40  ? 20.83873 19.36317  -6.68728  1.000 29.93675 ? 39  THR A CG2 1 
ATOM   224  N N   . GLY A 1 41  ? 20.14119 20.91565  -11.12319 1.000 29.70758 ? 40  GLY A N   1 
ATOM   225  C CA  . GLY A 1 41  ? 20.25474 21.88614  -12.18985 1.000 31.87266 ? 40  GLY A CA  1 
ATOM   226  C C   . GLY A 1 41  ? 20.30643 21.19628  -13.53293 1.000 34.43160 ? 40  GLY A C   1 
ATOM   227  O O   . GLY A 1 41  ? 20.08190 19.99085  -13.64469 1.000 28.92273 ? 40  GLY A O   1 
ATOM   228  N N   . LEU A 1 42  ? 20.62622 21.97603  -14.55853 1.000 29.58030 ? 41  LEU A N   1 
ATOM   229  C CA  . LEU A 1 42  ? 20.49066 21.49890  -15.92403 1.000 33.59031 ? 41  LEU A CA  1 
ATOM   230  C C   . LEU A 1 42  ? 21.82320 21.14808  -16.57058 1.000 28.69847 ? 41  LEU A C   1 
ATOM   231  O O   . LEU A 1 42  ? 21.84928 20.84142  -17.76249 1.000 29.12509 ? 41  LEU A O   1 
ATOM   232  C CB  . LEU A 1 42  ? 19.72258 22.52459  -16.77146 1.000 33.24385 ? 41  LEU A CB  1 
ATOM   233  C CG  . LEU A 1 42  ? 18.23853 22.77536  -16.42479 1.000 33.47141 ? 41  LEU A CG  1 
ATOM   234  C CD1 . LEU A 1 42  ? 18.02060 23.46911  -15.08428 1.000 47.55934 ? 41  LEU A CD1 1 
ATOM   235  C CD2 . LEU A 1 42  ? 17.55324 23.57596  -17.52056 1.000 39.22762 ? 41  LEU A CD2 1 
ATOM   236  N N   . SER A 1 43  ? 22.91857 21.14624  -15.82084 1.000 27.57733 ? 42  SER A N   1 
ATOM   237  C CA  . SER A 1 43  ? 24.21744 20.80490  -16.39617 1.000 31.32876 ? 42  SER A CA  1 
ATOM   238  C C   . SER A 1 43  ? 24.67335 19.44137  -15.90519 1.000 23.62927 ? 42  SER A C   1 
ATOM   239  O O   . SER A 1 43  ? 25.07587 19.30921  -14.73688 1.000 26.72860 ? 42  SER A O   1 
ATOM   240  C CB  . SER A 1 43  ? 25.26106 21.87294  -16.06436 1.000 35.70394 ? 42  SER A CB  1 
ATOM   241  O OG  . SER A 1 43  ? 24.70506 23.16303  -16.25158 1.000 43.65048 ? 42  SER A OG  1 
ATOM   242  N N   . PRO A 1 44  ? 24.63558 18.41146  -16.75524 1.000 24.82631 ? 43  PRO A N   1 
ATOM   243  C CA  . PRO A 1 44  ? 24.93089 17.05059  -16.28098 1.000 21.97359 ? 43  PRO A CA  1 
ATOM   244  C C   . PRO A 1 44  ? 26.31407 16.86943  -15.68843 1.000 23.48607 ? 43  PRO A C   1 
ATOM   245  O O   . PRO A 1 44  ? 26.49541 15.97586  -14.85452 1.000 23.82860 ? 43  PRO A O   1 
ATOM   246  C CB  . PRO A 1 44  ? 24.74277 16.19296  -17.54570 1.000 22.18579 ? 43  PRO A CB  1 
ATOM   247  C CG  . PRO A 1 44  ? 23.76918 16.94087  -18.37065 1.000 27.41870 ? 43  PRO A CG  1 
ATOM   248  C CD  . PRO A 1 44  ? 23.97351 18.41232  -18.07392 1.000 28.27320 ? 43  PRO A CD  1 
ATOM   249  N N   . LYS A 1 45  ? 27.30359 17.66635  -16.08598 1.000 24.58678 ? 44  LYS A N   1 
ATOM   250  C CA  . LYS A 1 45  ? 28.65467 17.47954  -15.56955 1.000 21.14558 ? 44  LYS A CA  1 
ATOM   251  C C   . LYS A 1 45  ? 28.96014 18.36395  -14.36612 1.000 24.71275 ? 44  LYS A C   1 
ATOM   252  O O   . LYS A 1 45  ? 30.06914 18.29658  -13.83113 1.000 25.56749 ? 44  LYS A O   1 
ATOM   253  C CB  . LYS A 1 45  ? 29.68225 17.73465  -16.69513 1.000 23.53732 ? 44  LYS A CB  1 
ATOM   254  C CG  . LYS A 1 45  ? 29.38656 16.94920  -17.97652 1.000 28.85863 ? 44  LYS A CG  1 
ATOM   255  C CD  . LYS A 1 45  ? 30.31669 17.30928  -19.16627 1.000 32.44354 ? 44  LYS A CD  1 
ATOM   256  C CE  . LYS A 1 45  ? 31.78334 16.96025  -18.92635 1.000 34.54479 ? 44  LYS A CE  1 
ATOM   257  N NZ  . LYS A 1 45  ? 32.65706 17.60321  -19.97403 1.000 31.08793 ? 44  LYS A NZ  1 
ATOM   258  N N   . ILE A 1 46  ? 28.00960 19.17788  -13.91875 1.000 25.73651 ? 45  ILE A N   1 
ATOM   259  C CA  . ILE A 1 46  ? 28.22666 20.11653  -12.82537 1.000 29.16706 ? 45  ILE A CA  1 
ATOM   260  C C   . ILE A 1 46  ? 27.21978 19.90866  -11.69951 1.000 28.04972 ? 45  ILE A C   1 
ATOM   261  O O   . ILE A 1 46  ? 27.58837 19.86062  -10.52285 1.000 27.80789 ? 45  ILE A O   1 
ATOM   262  C CB  . ILE A 1 46  ? 28.18042 21.57471  -13.32565 1.000 30.30351 ? 45  ILE A CB  1 
ATOM   263  C CG1 . ILE A 1 46  ? 29.33427 21.84428  -14.28813 1.000 26.22542 ? 45  ILE A CG1 1 
ATOM   264  C CG2 . ILE A 1 46  ? 28.24941 22.54828  -12.13968 1.000 27.57211 ? 45  ILE A CG2 1 
ATOM   265  C CD1 . ILE A 1 46  ? 29.09843 23.05769  -15.15147 1.000 38.78249 ? 45  ILE A CD1 1 
ATOM   266  N N   . ASP A 1 47  ? 25.94186 19.80242  -12.04010 1.000 24.06479 ? 46  ASP A N   1 
ATOM   267  C CA  . ASP A 1 47  ? 24.91004 19.79610  -11.01411 1.000 23.37345 ? 46  ASP A CA  1 
ATOM   268  C C   . ASP A 1 47  ? 24.77118 18.40857  -10.39053 1.000 26.32759 ? 46  ASP A C   1 
ATOM   269  O O   . ASP A 1 47  ? 25.40780 17.43862  -10.80670 1.000 27.70407 ? 46  ASP A O   1 
ATOM   270  C CB  . ASP A 1 47  ? 23.59204 20.30997  -11.59313 1.000 28.25425 ? 46  ASP A CB  1 
ATOM   271  C CG  . ASP A 1 47  ? 23.70349 21.75120  -12.06584 1.000 29.58575 ? 46  ASP A CG  1 
ATOM   272  O OD1 . ASP A 1 47  ? 24.29241 22.56303  -11.32042 1.000 33.78980 ? 46  ASP A OD1 1 
ATOM   273  O OD2 . ASP A 1 47  ? 23.20246 22.08878  -13.15047 1.000 32.31176 ? 46  ASP A OD2 1 
ATOM   274  N N   . GLY A 1 48  ? 23.96739 18.33353  -9.33282  1.000 26.51378 ? 47  GLY A N   1 
ATOM   275  C CA  . GLY A 1 48  ? 23.84185 17.10708  -8.56705  1.000 31.19706 ? 47  GLY A CA  1 
ATOM   276  C C   . GLY A 1 48  ? 22.71325 16.22173  -9.07038  1.000 23.85360 ? 47  GLY A C   1 
ATOM   277  O O   . GLY A 1 48  ? 21.64712 16.69951  -9.44801  1.000 23.50938 ? 47  GLY A O   1 
ATOM   278  N N   . LEU A 1 49  ? 22.96245 14.92041  -9.04891  1.000 20.98590 ? 48  LEU A N   1 
ATOM   279  C CA  . LEU A 1 49  ? 21.93756 13.93261  -9.33870  1.000 20.53707 ? 48  LEU A CA  1 
ATOM   280  C C   . LEU A 1 49  ? 21.27918 13.54169  -8.02318  1.000 21.15062 ? 48  LEU A C   1 
ATOM   281  O O   . LEU A 1 49  ? 21.93840 12.98353  -7.13819  1.000 21.06247 ? 48  LEU A O   1 
ATOM   282  C CB  . LEU A 1 49  ? 22.55017 12.71867  -10.02989 1.000 23.58904 ? 48  LEU A CB  1 
ATOM   283  C CG  . LEU A 1 49  ? 21.61552 11.55412  -10.32977 1.000 20.04720 ? 48  LEU A CG  1 
ATOM   284  C CD1 . LEU A 1 49  ? 20.50676 11.99863  -11.28236 1.000 20.29958 ? 48  LEU A CD1 1 
ATOM   285  C CD2 . LEU A 1 49  ? 22.42828 10.43563  -10.95099 1.000 20.87591 ? 48  LEU A CD2 1 
ATOM   286  N N   . CYS A 1 50  ? 19.98680 13.83358  -7.89710  1.000 19.16390 ? 49  CYS A N   1 
ATOM   287  C CA  . CYS A 1 50  ? 19.32509 13.61195  -6.60923  1.000 17.28849 ? 49  CYS A CA  1 
ATOM   288  C C   . CYS A 1 50  ? 18.63702 12.25744  -6.54668  1.000 21.93404 ? 49  CYS A C   1 
ATOM   289  O O   . CYS A 1 50  ? 18.79343 11.51764  -5.56681  1.000 22.17536 ? 49  CYS A O   1 
ATOM   290  C CB  . CYS A 1 50  ? 18.29482 14.70586  -6.35280  1.000 23.27788 ? 49  CYS A CB  1 
ATOM   291  S SG  . CYS A 1 50  ? 19.00240 16.34284  -6.30207  1.000 30.28460 ? 49  CYS A SG  1 
ATOM   292  N N   . THR A 1 51  ? 17.82482 11.95089  -7.55783  1.000 19.57191 ? 50  THR A N   1 
ATOM   293  C CA  . THR A 1 51  ? 17.09258 10.70035  -7.59934  1.000 18.91256 ? 50  THR A CA  1 
ATOM   294  C C   . THR A 1 51  ? 17.10470 10.17209  -9.02332  1.000 20.53488 ? 50  THR A C   1 
ATOM   295  O O   . THR A 1 51  ? 17.25375 10.92282  -9.98791  1.000 21.08344 ? 50  THR A O   1 
ATOM   296  C CB  . THR A 1 51  ? 15.62932 10.82910  -7.14151  1.000 23.71625 ? 50  THR A CB  1 
ATOM   297  O OG1 . THR A 1 51  ? 14.89823 11.60244  -8.09399  1.000 23.86950 ? 50  THR A OG1 1 
ATOM   298  C CG2 . THR A 1 51  ? 15.51052 11.48096  -5.75224  1.000 21.12648 ? 50  THR A CG2 1 
ATOM   299  N N   . VAL A 1 52  ? 16.94520 8.86119   -9.13249  1.000 17.03648 ? 51  VAL A N   1 
ATOM   300  C CA  . VAL A 1 52  ? 16.66669 8.19836   -10.39935 1.000 15.98827 ? 51  VAL A CA  1 
ATOM   301  C C   . VAL A 1 52  ? 15.33495 7.47691   -10.24907 1.000 20.00741 ? 51  VAL A C   1 
ATOM   302  O O   . VAL A 1 52  ? 15.16025 6.67796   -9.32161  1.000 20.11303 ? 51  VAL A O   1 
ATOM   303  C CB  . VAL A 1 52  ? 17.77675 7.21531   -10.78718 1.000 18.11465 ? 51  VAL A CB  1 
ATOM   304  C CG1 . VAL A 1 52  ? 17.48017 6.60687   -12.16999 1.000 18.13335 ? 51  VAL A CG1 1 
ATOM   305  C CG2 . VAL A 1 52  ? 19.14543 7.90877   -10.74249 1.000 17.48689 ? 51  VAL A CG2 1 
ATOM   306  N N   . GLN A 1 53  ? 14.39541 7.76338   -11.14566 1.000 16.37366 ? 52  GLN A N   1 
ATOM   307  C CA  . GLN A 1 53  ? 13.11724 7.06049   -11.17803 1.000 20.76889 ? 52  GLN A CA  1 
ATOM   308  C C   . GLN A 1 53  ? 13.18578 5.91793   -12.17652 1.000 20.51284 ? 52  GLN A C   1 
ATOM   309  O O   . GLN A 1 53  ? 13.67561 6.09852   -13.29193 1.000 18.62160 ? 52  GLN A O   1 
ATOM   310  C CB  . GLN A 1 53  ? 11.98397 8.00264   -11.57359 1.000 19.84102 ? 52  GLN A CB  1 
ATOM   311  C CG  . GLN A 1 53  ? 11.59997 8.96334   -10.46984 1.000 23.76239 ? 52  GLN A CG  1 
ATOM   312  C CD  . GLN A 1 53  ? 12.56916 10.09819  -10.29591 1.000 31.63469 ? 52  GLN A CD  1 
ATOM   313  O OE1 . GLN A 1 53  ? 13.18673 10.23163  -9.23878  1.000 37.59042 ? 52  GLN A OE1 1 
ATOM   314  N NE2 . GLN A 1 53  ? 12.70683 10.92849  -11.31820 1.000 27.63383 ? 52  GLN A NE2 1 
ATOM   315  N N   . LEU A 1 54  ? 12.68496 4.75248   -11.78224 1.000 16.85105 ? 53  LEU A N   1 
ATOM   316  C CA  . LEU A 1 54  ? 12.59687 3.61523   -12.68634 1.000 17.32347 ? 53  LEU A CA  1 
ATOM   317  C C   . LEU A 1 54  ? 11.20862 3.01083   -12.57240 1.000 19.75605 ? 53  LEU A C   1 
ATOM   318  O O   . LEU A 1 54  ? 10.73366 2.74301   -11.46256 1.000 19.37356 ? 53  LEU A O   1 
ATOM   319  C CB  . LEU A 1 54  ? 13.66961 2.56383   -12.36592 1.000 17.97624 ? 53  LEU A CB  1 
ATOM   320  C CG  . LEU A 1 54  ? 13.85119 1.41842   -13.37146 1.000 22.61789 ? 53  LEU A CG  1 
ATOM   321  C CD1 . LEU A 1 54  ? 15.29847 0.95626   -13.42468 1.000 27.75810 ? 53  LEU A CD1 1 
ATOM   322  C CD2 . LEU A 1 54  ? 12.90542 0.23198   -13.08935 1.000 22.31695 ? 53  LEU A CD2 1 
ATOM   323  N N   . HIS A 1 55  ? 10.57042 2.78500   -13.71262 1.000 18.14548 ? 54  HIS A N   1 
ATOM   324  C CA  . HIS A 1 55  ? 9.23885  2.19472   -13.77482 1.000 17.99388 ? 54  HIS A CA  1 
ATOM   325  C C   . HIS A 1 55  ? 9.29777  0.88654   -14.55225 1.000 21.91928 ? 54  HIS A C   1 
ATOM   326  O O   . HIS A 1 55  ? 9.92394  0.82228   -15.60981 1.000 17.58501 ? 54  HIS A O   1 
ATOM   327  C CB  . HIS A 1 55  ? 8.25231  3.16819   -14.42630 1.000 18.48138 ? 54  HIS A CB  1 
ATOM   328  C CG  . HIS A 1 55  ? 6.91220  2.56663   -14.72757 1.000 22.57397 ? 54  HIS A CG  1 
ATOM   329  N ND1 . HIS A 1 55  ? 6.00776  2.22354   -13.74682 1.000 23.54070 ? 54  HIS A ND1 1 
ATOM   330  C CD2 . HIS A 1 55  ? 6.31778  2.26641   -15.90742 1.000 26.34004 ? 54  HIS A CD2 1 
ATOM   331  C CE1 . HIS A 1 55  ? 4.92198  1.72006   -14.30632 1.000 26.53834 ? 54  HIS A CE1 1 
ATOM   332  N NE2 . HIS A 1 55  ? 5.08221  1.74025   -15.61986 1.000 27.70270 ? 54  HIS A NE2 1 
ATOM   333  N N   . VAL A 1 56  ? 8.69119  -0.16062  -14.00957 1.000 17.92402 ? 55  VAL A N   1 
ATOM   334  C CA  . VAL A 1 56  ? 8.50526  -1.42532  -14.71778 1.000 21.20233 ? 55  VAL A CA  1 
ATOM   335  C C   . VAL A 1 56  ? 7.02949  -1.51713  -15.09565 1.000 24.81909 ? 55  VAL A C   1 
ATOM   336  O O   . VAL A 1 56  ? 6.17123  -1.48496  -14.20778 1.000 24.05976 ? 55  VAL A O   1 
ATOM   337  C CB  . VAL A 1 56  ? 8.94000  -2.62815  -13.86109 1.000 25.30669 ? 55  VAL A CB  1 
ATOM   338  C CG1 . VAL A 1 56  ? 8.75332  -3.94542  -14.62268 1.000 24.18482 ? 55  VAL A CG1 1 
ATOM   339  C CG2 . VAL A 1 56  ? 10.39928 -2.48010  -13.42484 1.000 21.59579 ? 55  VAL A CG2 1 
ATOM   340  N N   . PRO A 1 57  ? 6.68557  -1.58018  -16.38062 1.000 30.82270 ? 56  PRO A N   1 
ATOM   341  C CA  . PRO A 1 57  ? 5.26456  -1.55271  -16.76602 1.000 29.54160 ? 56  PRO A CA  1 
ATOM   342  C C   . PRO A 1 57  ? 4.47914  -2.70522  -16.15375 1.000 27.36553 ? 56  PRO A C   1 
ATOM   343  O O   . PRO A 1 57  ? 4.90750  -3.86000  -16.17374 1.000 33.35284 ? 56  PRO A O   1 
ATOM   344  C CB  . PRO A 1 57  ? 5.29975  -1.63395  -18.29927 1.000 31.64948 ? 56  PRO A CB  1 
ATOM   345  C CG  . PRO A 1 57  ? 6.67428  -1.28602  -18.70677 1.000 28.52044 ? 56  PRO A CG  1 
ATOM   346  C CD  . PRO A 1 57  ? 7.59753  -1.36476  -17.51594 1.000 25.43134 ? 56  PRO A CD  1 
ATOM   347  N N   . GLY A 1 58  ? 3.32611  -2.37140  -15.58324 1.000 33.12190 ? 57  GLY A N   1 
ATOM   348  C CA  . GLY A 1 58  ? 2.49271  -3.33648  -14.90990 1.000 34.26410 ? 57  GLY A CA  1 
ATOM   349  C C   . GLY A 1 58  ? 2.84946  -3.59733  -13.46082 1.000 32.43568 ? 57  GLY A C   1 
ATOM   350  O O   . GLY A 1 58  ? 2.05417  -4.22827  -12.75140 1.000 33.12185 ? 57  GLY A O   1 
ATOM   351  N N   . VAL A 1 59  ? 4.00763  -3.12827  -12.99420 1.000 28.73938 ? 58  VAL A N   1 
ATOM   352  C CA  . VAL A 1 59  ? 4.51437  -3.44233  -11.66115 1.000 28.34109 ? 58  VAL A CA  1 
ATOM   353  C C   . VAL A 1 59  ? 4.50393  -2.21073  -10.75826 1.000 30.75379 ? 58  VAL A C   1 
ATOM   354  O O   . VAL A 1 59  ? 3.89690  -2.22257  -9.68794  1.000 32.76921 ? 58  VAL A O   1 
ATOM   355  C CB  . VAL A 1 59  ? 5.92438  -4.06925  -11.73731 1.000 29.77237 ? 58  VAL A CB  1 
ATOM   356  C CG1 . VAL A 1 59  ? 6.44423  -4.36556  -10.34109 1.000 26.86105 ? 58  VAL A CG1 1 
ATOM   357  C CG2 . VAL A 1 59  ? 5.89111  -5.32891  -12.58390 1.000 31.96727 ? 58  VAL A CG2 1 
ATOM   358  N N   . GLY A 1 60  ? 5.17349  -1.14475  -11.16861 1.000 25.13520 ? 59  GLY A N   1 
ATOM   359  C CA  . GLY A 1 60  ? 5.22214  0.06461   -10.37433 1.000 27.84993 ? 59  GLY A CA  1 
ATOM   360  C C   . GLY A 1 60  ? 6.51341  0.82152   -10.61361 1.000 25.20652 ? 59  GLY A C   1 
ATOM   361  O O   . GLY A 1 60  ? 7.22576  0.58238   -11.59221 1.000 23.96533 ? 59  GLY A O   1 
ATOM   362  N N   . THR A 1 61  ? 6.79586  1.73580   -9.69219  1.000 19.52377 ? 60  THR A N   1 
ATOM   363  C CA  . THR A 1 61  ? 7.88432  2.68512   -9.84851  1.000 19.52082 ? 60  THR A CA  1 
ATOM   364  C C   . THR A 1 61  ? 8.70401  2.74873   -8.57377  1.000 21.37713 ? 60  THR A C   1 
ATOM   365  O O   . THR A 1 61  ? 8.15096  2.67809   -7.47328  1.000 21.51247 ? 60  THR A O   1 
ATOM   366  C CB  . THR A 1 61  ? 7.33937  4.07640   -10.19638 1.000 23.68935 ? 60  THR A CB  1 
ATOM   367  O OG1 . THR A 1 61  ? 6.70667  4.01782   -11.48425 1.000 21.79869 ? 60  THR A OG1 1 
ATOM   368  C CG2 . THR A 1 61  ? 8.45166  5.10893   -10.22506 1.000 23.31881 ? 60  THR A CG2 1 
ATOM   369  N N   . GLU A 1 62  ? 10.02057 2.87876   -8.72596  1.000 19.44504 ? 61  GLU A N   1 
ATOM   370  C CA  . GLU A 1 62  ? 10.90471 3.14642   -7.59990  1.000 19.50447 ? 61  GLU A CA  1 
ATOM   371  C C   . GLU A 1 62  ? 11.56991 4.49204   -7.80701  1.000 21.11741 ? 61  GLU A C   1 
ATOM   372  O O   . GLU A 1 62  ? 11.99642 4.82719   -8.91735  1.000 19.78282 ? 61  GLU A O   1 
ATOM   373  C CB  . GLU A 1 62  ? 11.95684 2.03652   -7.42797  1.000 18.92329 ? 61  GLU A CB  1 
ATOM   374  C CG  . GLU A 1 62  ? 11.39190 0.85153   -6.66783  1.000 23.68555 ? 61  GLU A CG  1 
ATOM   375  C CD  . GLU A 1 62  ? 12.39215 -0.25323  -6.36035  1.000 22.66658 ? 61  GLU A CD  1 
ATOM   376  O OE1 . GLU A 1 62  ? 13.58354 -0.12724  -6.70588  1.000 20.66658 ? 61  GLU A OE1 1 
ATOM   377  O OE2 . GLU A 1 62  ? 11.97413 -1.24988  -5.73620  1.000 23.85172 ? 61  GLU A OE2 1 
ATOM   378  N N   . ILE A 1 63  ? 11.62989 5.27514   -6.73900  1.000 18.26670 ? 62  ILE A N   1 
ATOM   379  C CA  . ILE A 1 63  ? 12.42622 6.48859   -6.70442  1.000 18.64984 ? 62  ILE A CA  1 
ATOM   380  C C   . ILE A 1 63  ? 13.69887 6.12521   -5.96009  1.000 23.26457 ? 62  ILE A C   1 
ATOM   381  O O   . ILE A 1 63  ? 13.65345 5.84567   -4.75899  1.000 20.72912 ? 62  ILE A O   1 
ATOM   382  C CB  . ILE A 1 63  ? 11.68302 7.63602   -6.00934  1.000 19.93018 ? 62  ILE A CB  1 
ATOM   383  C CG1 . ILE A 1 63  ? 10.34894 7.91700   -6.70382  1.000 26.52544 ? 62  ILE A CG1 1 
ATOM   384  C CG2 . ILE A 1 63  ? 12.56158 8.88062   -5.92413  1.000 19.55505 ? 62  ILE A CG2 1 
ATOM   385  C CD1 . ILE A 1 63  ? 9.53281  8.98070   -5.99238  1.000 25.31634 ? 62  ILE A CD1 1 
ATOM   386  N N   . VAL A 1 64  ? 14.82793 6.10061   -6.66076  1.000 16.82289 ? 63  VAL A N   1 
ATOM   387  C CA  . VAL A 1 64  ? 16.10641 5.77077   -6.03842  1.000 17.50246 ? 63  VAL A CA  1 
ATOM   388  C C   . VAL A 1 64  ? 16.77639 7.06507   -5.59133  1.000 18.18548 ? 63  VAL A C   1 
ATOM   389  O O   . VAL A 1 64  ? 17.19051 7.88559   -6.41107  1.000 18.42390 ? 63  VAL A O   1 
ATOM   390  C CB  . VAL A 1 64  ? 17.01329 4.97136   -6.97888  1.000 21.55613 ? 63  VAL A CB  1 
ATOM   391  C CG1 . VAL A 1 64  ? 18.32033 4.62681   -6.26310  1.000 20.55934 ? 63  VAL A CG1 1 
ATOM   392  C CG2 . VAL A 1 64  ? 16.30797 3.68641   -7.45745  1.000 19.22293 ? 63  VAL A CG2 1 
ATOM   393  N N   . ARG A 1 65  ? 16.92060 7.23359   -4.27589  1.000 16.99503 ? 64  ARG A N   1 
ATOM   394  C CA  . ARG A 1 65  ? 17.62462 8.38588   -3.71979  1.000 19.61642 ? 64  ARG A CA  1 
ATOM   395  C C   . ARG A 1 65  ? 19.12610 8.13700   -3.77531  1.000 21.23120 ? 64  ARG A C   1 
ATOM   396  O O   . ARG A 1 65  ? 19.62215 7.19184   -3.15618  1.000 24.28681 ? 64  ARG A O   1 
ATOM   397  C CB  . ARG A 1 65  ? 17.16993 8.60150   -2.27777  1.000 15.98771 ? 64  ARG A CB  1 
ATOM   398  C CG  . ARG A 1 65  ? 15.78816 9.21124   -2.20193  1.000 20.66341 ? 64  ARG A CG  1 
ATOM   399  C CD  . ARG A 1 65  ? 15.57605 9.83281   -0.84709  1.000 33.00171 ? 64  ARG A CD  1 
ATOM   400  N NE  . ARG A 1 65  ? 15.72704 11.27728  -0.92028  1.000 48.11589 ? 64  ARG A NE  1 
ATOM   401  C CZ  . ARG A 1 65  ? 15.47891 12.10173  0.08537   1.000 53.86175 ? 64  ARG A CZ  1 
ATOM   402  N NH1 . ARG A 1 65  ? 15.02832 11.65587  1.24655   1.000 55.06801 ? 64  ARG A NH1 1 
ATOM   403  N NH2 . ARG A 1 65  ? 15.68714 13.40450  -0.08011  1.000 59.35050 ? 64  ARG A NH2 1 
ATOM   404  N N   . VAL A 1 66  ? 19.85371 8.97367   -4.51791  1.000 18.14247 ? 65  VAL A N   1 
ATOM   405  C CA  . VAL A 1 66  ? 21.28412 8.75727   -4.70055  1.000 20.20263 ? 65  VAL A CA  1 
ATOM   406  C C   . VAL A 1 66  ? 22.02427 9.00077   -3.38818  1.000 26.81978 ? 65  VAL A C   1 
ATOM   407  O O   . VAL A 1 66  ? 21.81803 10.01843  -2.71277  1.000 29.79586 ? 65  VAL A O   1 
ATOM   408  C CB  . VAL A 1 66  ? 21.82171 9.66090   -5.81993  1.000 21.97854 ? 65  VAL A CB  1 
ATOM   409  C CG1 . VAL A 1 66  ? 23.35663 9.61810   -5.86831  1.000 27.78852 ? 65  VAL A CG1 1 
ATOM   410  C CG2 . VAL A 1 66  ? 21.22539 9.24672   -7.13863  1.000 24.44950 ? 65  VAL A CG2 1 
ATOM   411  N N   . ASP A 1 67  ? 22.90458 8.06617   -3.03275  1.000 26.38435 ? 66  ASP A N   1 
ATOM   412  C CA  . ASP A 1 67  ? 23.76102 8.16864   -1.85140  1.000 31.53319 ? 66  ASP A CA  1 
ATOM   413  C C   . ASP A 1 67  ? 25.19185 8.33289   -2.33013  1.000 36.09677 ? 66  ASP A C   1 
ATOM   414  O O   . ASP A 1 67  ? 25.70974 7.43519   -3.01475  1.000 33.74092 ? 66  ASP A O   1 
ATOM   415  C CB  . ASP A 1 67  ? 23.61163 6.91993   -0.97870  1.000 27.40717 ? 66  ASP A CB  1 
ATOM   416  C CG  . ASP A 1 67  ? 24.40907 6.98709   0.33366   1.000 36.73201 ? 66  ASP A CG  1 
ATOM   417  O OD1 . ASP A 1 67  ? 25.43745 7.69124   0.41453   1.000 30.57943 ? 66  ASP A OD1 1 
ATOM   418  O OD2 . ASP A 1 67  ? 23.96953 6.33134   1.29953   1.000 36.87570 ? 66  ASP A OD2 1 
ATOM   419  N N   . PRO A 1 68  ? 25.84897 9.46194   -2.04467  1.000 41.53810 ? 67  PRO A N   1 
ATOM   420  C CA  . PRO A 1 68  ? 27.20286 9.67964   -2.58835  1.000 42.28674 ? 67  PRO A CA  1 
ATOM   421  C C   . PRO A 1 68  ? 28.21844 8.64731   -2.14309  1.000 42.00520 ? 67  PRO A C   1 
ATOM   422  O O   . PRO A 1 68  ? 29.23698 8.47617   -2.82194  1.000 47.09337 ? 67  PRO A O   1 
ATOM   423  C CB  . PRO A 1 68  ? 27.58030 11.07619  -2.07592  1.000 38.72116 ? 67  PRO A CB  1 
ATOM   424  C CG  . PRO A 1 68  ? 26.30147 11.72714  -1.68570  1.000 45.94317 ? 67  PRO A CG  1 
ATOM   425  C CD  . PRO A 1 68  ? 25.18999 10.71821  -1.66061  1.000 42.26204 ? 67  PRO A CD  1 
ATOM   426  N N   . THR A 1 69  ? 27.97839 7.94860   -1.03552  1.000 36.29792 ? 68  THR A N   1 
ATOM   427  C CA  . THR A 1 69  ? 28.90306 6.94440   -0.53177  1.000 39.67605 ? 68  THR A CA  1 
ATOM   428  C C   . THR A 1 69  ? 28.57127 5.53400   -1.01025  1.000 44.68760 ? 68  THR A C   1 
ATOM   429  O O   . THR A 1 69  ? 29.22207 4.57868   -0.57430  1.000 47.13240 ? 68  THR A O   1 
ATOM   430  C CB  . THR A 1 69  ? 28.93432 6.98285   1.00267   1.000 40.70014 ? 68  THR A CB  1 
ATOM   431  O OG1 . THR A 1 69  ? 27.73281 6.40632   1.53702   1.000 39.42954 ? 68  THR A OG1 1 
ATOM   432  C CG2 . THR A 1 69  ? 29.05649 8.41887   1.48570   1.000 42.00860 ? 68  THR A CG2 1 
ATOM   433  N N   . LEU A 1 70  ? 27.59292 5.38220   -1.90273  1.000 34.81161 ? 69  LEU A N   1 
ATOM   434  C CA  . LEU A 1 70  ? 27.11949 4.07049   -2.32885  1.000 34.25961 ? 69  LEU A CA  1 
ATOM   435  C C   . LEU A 1 70  ? 26.93543 4.05671   -3.84036  1.000 28.29416 ? 69  LEU A C   1 
ATOM   436  O O   . LEU A 1 70  ? 26.22473 4.90291   -4.38374  1.000 34.73887 ? 69  LEU A O   1 
ATOM   437  C CB  . LEU A 1 70  ? 25.78945 3.72657   -1.65110  1.000 32.82079 ? 69  LEU A CB  1 
ATOM   438  C CG  . LEU A 1 70  ? 25.77731 3.36839   -0.16554  1.000 40.79076 ? 69  LEU A CG  1 
ATOM   439  C CD1 . LEU A 1 70  ? 24.37139 2.94873   0.24256   1.000 36.95449 ? 69  LEU A CD1 1 
ATOM   440  C CD2 . LEU A 1 70  ? 26.77989 2.26668   0.14829   1.000 48.99792 ? 69  LEU A CD2 1 
ATOM   441  N N   . GLN A 1 71  ? 27.57804 3.11728   -4.51455  1.000 29.74521 ? 70  GLN A N   1 
ATOM   442  C CA  . GLN A 1 71  ? 27.28780 2.90605   -5.93173  1.000 28.35888 ? 70  GLN A CA  1 
ATOM   443  C C   . GLN A 1 71  ? 25.94023 2.19626   -6.04461  1.000 29.72453 ? 70  GLN A C   1 
ATOM   444  O O   . GLN A 1 71  ? 25.69709 1.22247   -5.31719  1.000 28.01786 ? 70  GLN A O   1 
ATOM   445  C CB  . GLN A 1 71  ? 28.40164 2.08048   -6.58090  1.000 31.71268 ? 70  GLN A CB  1 
ATOM   446  C CG  . GLN A 1 71  ? 29.62926 2.89426   -7.03969  1.000 34.77010 ? 70  GLN A CG  1 
ATOM   447  C CD  . GLN A 1 71  ? 29.44484 3.64595   -8.35742  1.000 42.99959 ? 70  GLN A CD  1 
ATOM   448  O OE1 . GLN A 1 71  ? 29.43331 4.87777   -8.39008  1.000 47.71308 ? 70  GLN A OE1 1 
ATOM   449  N NE2 . GLN A 1 71  ? 29.39963 2.90431   -9.45805  1.000 42.58335 ? 70  GLN A NE2 1 
ATOM   450  N N   . PRO A 1 72  ? 25.01873 2.66604   -6.90762  1.000 24.20166 ? 71  PRO A N   1 
ATOM   451  C CA  . PRO A 1 72  ? 23.72148 1.95902   -7.03080  1.000 21.72480 ? 71  PRO A CA  1 
ATOM   452  C C   . PRO A 1 72  ? 23.85327 0.74184   -7.94133  1.000 24.06026 ? 71  PRO A C   1 
ATOM   453  O O   . PRO A 1 72  ? 23.50158 0.75134   -9.12070  1.000 20.26070 ? 71  PRO A O   1 
ATOM   454  C CB  . PRO A 1 72  ? 22.80583 3.03327   -7.62176  1.000 23.71454 ? 71  PRO A CB  1 
ATOM   455  C CG  . PRO A 1 72  ? 23.72765 3.86953   -8.45866  1.000 25.17869 ? 71  PRO A CG  1 
ATOM   456  C CD  . PRO A 1 72  ? 25.05260 3.89613   -7.71683  1.000 27.65630 ? 71  PRO A CD  1 
ATOM   457  N N   . THR A 1 73  ? 24.36036 -0.34377  -7.35378  1.000 21.57551 ? 72  THR A N   1 
ATOM   458  C CA  . THR A 1 73  ? 24.87018 -1.47157  -8.13269  1.000 23.62021 ? 72  THR A CA  1 
ATOM   459  C C   . THR A 1 73  ? 23.80679 -2.05335  -9.06445  1.000 20.50096 ? 72  THR A C   1 
ATOM   460  O O   . THR A 1 73  ? 24.06313 -2.28094  -10.25467 1.000 22.63064 ? 72  THR A O   1 
ATOM   461  C CB  . THR A 1 73  ? 25.38176 -2.55080  -7.18522  1.000 28.18724 ? 72  THR A CB  1 
ATOM   462  O OG1 . THR A 1 73  ? 26.52272 -2.05009  -6.47377  1.000 33.85749 ? 72  THR A OG1 1 
ATOM   463  C CG2 . THR A 1 73  ? 25.78226 -3.78269  -7.97741  1.000 25.42040 ? 72  THR A CG2 1 
ATOM   464  N N   . ARG A 1 74  ? 22.60920 -2.31576  -8.53505  1.000 19.76978 ? 73  ARG A N   1 
ATOM   465  C CA  . ARG A 1 74  ? 21.58011 -2.96083  -9.34230  1.000 19.88351 ? 73  ARG A CA  1 
ATOM   466  C C   . ARG A 1 74  ? 21.06255 -2.01607  -10.42492 1.000 20.87151 ? 73  ARG A C   1 
ATOM   467  O O   . ARG A 1 74  ? 20.81094 -2.44234  -11.56015 1.000 18.87867 ? 73  ARG A O   1 
ATOM   468  C CB  . ARG A 1 74  ? 20.45326 -3.46576  -8.43961  1.000 18.81429 ? 73  ARG A CB  1 
ATOM   469  C CG  . ARG A 1 74  ? 20.91237 -4.60430  -7.50304  1.000 20.51082 ? 73  ARG A CG  1 
ATOM   470  C CD  . ARG A 1 74  ? 19.75546 -5.21552  -6.71228  1.000 25.20908 ? 73  ARG A CD  1 
ATOM   471  N NE  . ARG A 1 74  ? 19.33459 -4.30633  -5.65979  1.000 29.72421 ? 73  ARG A NE  1 
ATOM   472  C CZ  . ARG A 1 74  ? 19.87372 -4.23915  -4.44592  1.000 23.01929 ? 73  ARG A CZ  1 
ATOM   473  N NH1 . ARG A 1 74  ? 20.77785 -5.11643  -4.03530  1.000 29.69230 ? 73  ARG A NH1 1 
ATOM   474  N NH2 . ARG A 1 74  ? 19.50183 -3.26216  -3.63020  1.000 24.28128 ? 73  ARG A NH2 1 
ATOM   475  N N   . LEU A 1 75  ? 20.92747 -0.72570  -10.10343 1.000 18.52658 ? 74  LEU A N   1 
ATOM   476  C CA  . LEU A 1 75  ? 20.54577 0.25869   -11.11545 1.000 19.45622 ? 74  LEU A CA  1 
ATOM   477  C C   . LEU A 1 75  ? 21.54803 0.27900   -12.26191 1.000 18.04818 ? 74  LEU A C   1 
ATOM   478  O O   . LEU A 1 75  ? 21.16988 0.31799   -13.44369 1.000 19.27903 ? 74  LEU A O   1 
ATOM   479  C CB  . LEU A 1 75  ? 20.45212 1.64394   -10.48492 1.000 18.78917 ? 74  LEU A CB  1 
ATOM   480  C CG  . LEU A 1 75  ? 20.13776 2.79866   -11.43970 1.000 22.09416 ? 74  LEU A CG  1 
ATOM   481  C CD1 . LEU A 1 75  ? 18.80383 2.57135   -12.13722 1.000 22.46988 ? 74  LEU A CD1 1 
ATOM   482  C CD2 . LEU A 1 75  ? 20.13486 4.11733   -10.67895 1.000 23.59710 ? 74  LEU A CD2 1 
ATOM   483  N N   . LEU A 1 76  ? 22.83698 0.29184   -11.92446 1.000 17.69444 ? 75  LEU A N   1 
ATOM   484  C CA  . LEU A 1 76  ? 23.87359 0.28782   -12.95017 1.000 18.21644 ? 75  LEU A CA  1 
ATOM   485  C C   . LEU A 1 76  ? 23.84387 -0.99175  -13.77244 1.000 19.82269 ? 75  LEU A C   1 
ATOM   486  O O   . LEU A 1 76  ? 24.13972 -0.95750  -14.97600 1.000 20.27386 ? 75  LEU A O   1 
ATOM   487  C CB  . LEU A 1 76  ? 25.24183 0.46933   -12.30892 1.000 22.95309 ? 75  LEU A CB  1 
ATOM   488  C CG  . LEU A 1 76  ? 25.39230 1.77926   -11.53858 1.000 26.64764 ? 75  LEU A CG  1 
ATOM   489  C CD1 . LEU A 1 76  ? 26.74330 1.83194   -10.81011 1.000 27.10061 ? 75  LEU A CD1 1 
ATOM   490  C CD2 . LEU A 1 76  ? 25.22721 2.95929   -12.47067 1.000 31.22569 ? 75  LEU A CD2 1 
ATOM   491  N N   . GLN A 1 77  ? 23.50673 -2.12735  -13.15044 1.000 17.07870 ? 76  GLN A N   1 
ATOM   492  C CA  . GLN A 1 77  ? 23.32293 -3.35189  -13.92963 1.000 21.08639 ? 76  GLN A CA  1 
ATOM   493  C C   . GLN A 1 77  ? 22.18653 -3.20783  -14.93202 1.000 20.74464 ? 76  GLN A C   1 
ATOM   494  O O   . GLN A 1 77  ? 22.30582 -3.65114  -16.08272 1.000 19.48577 ? 76  GLN A O   1 
ATOM   495  C CB  . GLN A 1 77  ? 23.04885 -4.55597  -13.02419 1.000 23.16571 ? 76  GLN A CB  1 
ATOM   496  C CG  . GLN A 1 77  ? 24.17207 -4.93090  -12.06985 1.000 29.44586 ? 76  GLN A CG  1 
ATOM   497  C CD  . GLN A 1 77  ? 23.78451 -6.08935  -11.16093 1.000 34.17602 ? 76  GLN A CD  1 
ATOM   498  O OE1 . GLN A 1 77  ? 23.25448 -5.89031  -10.07765 1.000 33.74096 ? 76  GLN A OE1 1 
ATOM   499  N NE2 . GLN A 1 77  ? 24.03831 -7.31029  -11.61792 1.000 39.29053 ? 76  GLN A NE2 1 
ATOM   500  N N   . VAL A 1 78  ? 21.05673 -2.63582  -14.50224 1.000 19.60081 ? 77  VAL A N   1 
ATOM   501  C CA  . VAL A 1 78  ? 19.94299 -2.41820  -15.42904 1.000 18.37724 ? 77  VAL A CA  1 
ATOM   502  C C   . VAL A 1 78  ? 20.38315 -1.52202  -16.57700 1.000 18.24744 ? 77  VAL A C   1 
ATOM   503  O O   . VAL A 1 78  ? 20.09093 -1.79150  -17.74870 1.000 17.78556 ? 77  VAL A O   1 
ATOM   504  C CB  . VAL A 1 78  ? 18.72931 -1.81553  -14.70120 1.000 17.12420 ? 77  VAL A CB  1 
ATOM   505  C CG1 . VAL A 1 78  ? 17.67309 -1.33997  -15.73154 1.000 17.78169 ? 77  VAL A CG1 1 
ATOM   506  C CG2 . VAL A 1 78  ? 18.12152 -2.83941  -13.76376 1.000 19.87276 ? 77  VAL A CG2 1 
ATOM   507  N N   . LEU A 1 79  ? 21.07218 -0.42714  -16.25434 1.000 16.62374 ? 78  LEU A N   1 
ATOM   508  C CA  . LEU A 1 79  ? 21.43459 0.52849   -17.29309 1.000 20.15211 ? 78  LEU A CA  1 
ATOM   509  C C   . LEU A 1 79  ? 22.38866 -0.10138  -18.28876 1.000 18.54988 ? 78  LEU A C   1 
ATOM   510  O O   . LEU A 1 79  ? 22.30134 0.16147   -19.49551 1.000 18.39155 ? 78  LEU A O   1 
ATOM   511  C CB  . LEU A 1 79  ? 22.04665 1.78067   -16.66998 1.000 21.03611 ? 78  LEU A CB  1 
ATOM   512  C CG  . LEU A 1 79  ? 20.99784 2.69699   -16.03630 1.000 20.11829 ? 78  LEU A CG  1 
ATOM   513  C CD1 . LEU A 1 79  ? 21.63975 3.60202   -14.96840 1.000 21.65027 ? 78  LEU A CD1 1 
ATOM   514  C CD2 . LEU A 1 79  ? 20.35803 3.52820   -17.14314 1.000 18.96435 ? 78  LEU A CD2 1 
ATOM   515  N N   . ALA A 1 80  ? 23.28677 -0.96486  -17.80639 1.000 18.34488 ? 79  ALA A N   1 
ATOM   516  C CA  . ALA A 1 80  ? 24.26676 -1.61471  -18.67304 1.000 20.31258 ? 79  ALA A CA  1 
ATOM   517  C C   . ALA A 1 80  ? 23.71651 -2.83069  -19.41645 1.000 19.57976 ? 79  ALA A C   1 
ATOM   518  O O   . ALA A 1 80  ? 24.36587 -3.30431  -20.35182 1.000 26.70745 ? 79  ALA A O   1 
ATOM   519  C CB  . ALA A 1 80  ? 25.49012 -2.03357  -17.84837 1.000 23.12258 ? 79  ALA A CB  1 
ATOM   520  N N   . ALA A 1 81  ? 22.54343 -3.33005  -19.05591 1.000 19.23221 ? 80  ALA A N   1 
ATOM   521  C CA  . ALA A 1 81  ? 22.05751 -4.60364  -19.57624 1.000 22.41845 ? 80  ALA A CA  1 
ATOM   522  C C   . ALA A 1 81  ? 21.59546 -4.46307  -21.02710 1.000 22.29872 ? 80  ALA A C   1 
ATOM   523  O O   . ALA A 1 81  ? 20.64840 -3.72662  -21.31494 1.000 19.80347 ? 80  ALA A O   1 
ATOM   524  C CB  . ALA A 1 81  ? 20.91395 -5.11038  -18.70535 1.000 19.82052 ? 80  ALA A CB  1 
ATOM   525  N N   . GLU A 1 82  ? 22.23208 -5.20063  -21.94203 1.000 22.93501 ? 81  GLU A N   1 
ATOM   526  C CA  . GLU A 1 82  ? 21.78433 -5.14513  -23.33315 1.000 25.96600 ? 81  GLU A CA  1 
ATOM   527  C C   . GLU A 1 82  ? 20.37610 -5.68587  -23.49499 1.000 27.04601 ? 81  GLU A C   1 
ATOM   528  O O   . GLU A 1 82  ? 19.65160 -5.27171  -24.41170 1.000 22.80789 ? 81  GLU A O   1 
ATOM   529  C CB  . GLU A 1 82  ? 22.71918 -5.92818  -24.25052 1.000 27.29734 ? 81  GLU A CB  1 
ATOM   530  C CG  . GLU A 1 82  ? 24.10967 -5.38138  -24.35629 1.000 37.09065 ? 81  GLU A CG  1 
ATOM   531  C CD  . GLU A 1 82  ? 24.91623 -6.09506  -25.43173 1.000 48.58484 ? 81  GLU A CD  1 
ATOM   532  O OE1 . GLU A 1 82  ? 25.26746 -7.28060  -25.23597 1.000 50.65261 ? 81  GLU A OE1 1 
ATOM   533  O OE2 . GLU A 1 82  ? 25.18059 -5.46676  -26.48249 1.000 50.39459 ? 81  GLU A OE2 1 
ATOM   534  N N   A GLU A 1 83  ? 19.96037 -6.61444  -22.63349 0.394 24.48427 ? 82  GLU A N   1 
ATOM   535  N N   B GLU A 1 83  ? 19.97248 -6.58937  -22.61191 0.606 24.43229 ? 82  GLU A N   1 
ATOM   536  C CA  A GLU A 1 83  ? 18.67076 -7.28005  -22.78462 0.394 27.74189 ? 82  GLU A CA  1 
ATOM   537  C CA  B GLU A 1 83  ? 18.71312 -7.29620  -22.73245 0.606 27.76031 ? 82  GLU A CA  1 
ATOM   538  C C   A GLU A 1 83  ? 17.52570 -6.56068  -22.08160 0.394 28.89986 ? 82  GLU A C   1 
ATOM   539  C C   B GLU A 1 83  ? 17.53286 -6.53264  -22.14165 0.606 28.95081 ? 82  GLU A C   1 
ATOM   540  O O   A GLU A 1 83  ? 16.40329 -7.07872  -22.07226 0.394 30.60816 ? 82  GLU A O   1 
ATOM   541  O O   B GLU A 1 83  ? 16.39111 -6.98066  -22.29329 0.606 31.05046 ? 82  GLU A O   1 
ATOM   542  C CB  A GLU A 1 83  ? 18.74626 -8.72307  -22.27091 0.394 28.43288 ? 82  GLU A CB  1 
ATOM   543  C CB  B GLU A 1 83  ? 18.84526 -8.67489  -22.07026 0.606 28.54585 ? 82  GLU A CB  1 
ATOM   544  C CG  A GLU A 1 83  ? 19.48547 -9.68545  -23.18523 0.394 26.01891 ? 82  GLU A CG  1 
ATOM   545  C CG  B GLU A 1 83  ? 18.90362 -8.65620  -20.54924 0.606 28.48188 ? 82  GLU A CG  1 
ATOM   546  C CD  A GLU A 1 83  ? 18.96793 -9.66331  -24.61834 0.394 30.95445 ? 82  GLU A CD  1 
ATOM   547  C CD  B GLU A 1 83  ? 20.29824 -8.45909  -19.93684 0.606 27.66333 ? 82  GLU A CD  1 
ATOM   548  O OE1 A GLU A 1 83  ? 17.77684 -9.97180  -24.83133 0.394 30.86270 ? 82  GLU A OE1 1 
ATOM   549  O OE1 B GLU A 1 83  ? 21.27077 -8.08819  -20.63825 0.606 20.99295 ? 82  GLU A OE1 1 
ATOM   550  O OE2 A GLU A 1 83  ? 19.75610 -9.33524  -25.53170 0.394 31.08008 ? 82  GLU A OE2 1 
ATOM   551  O OE2 B GLU A 1 83  ? 20.40430 -8.67573  -18.70890 0.606 32.35945 ? 82  GLU A OE2 1 
ATOM   552  N N   . ILE A 1 84  ? 17.76885 -5.39973  -21.48228 1.000 20.78184 ? 83  ILE A N   1 
ATOM   553  C CA  . ILE A 1 84  ? 16.70460 -4.57244  -20.91745 1.000 18.91166 ? 83  ILE A CA  1 
ATOM   554  C C   . ILE A 1 84  ? 16.72491 -3.24532  -21.65834 1.000 20.93573 ? 83  ILE A C   1 
ATOM   555  O O   . ILE A 1 84  ? 17.73463 -2.53213  -21.63311 1.000 20.78960 ? 83  ILE A O   1 
ATOM   556  C CB  . ILE A 1 84  ? 16.86922 -4.34500  -19.40512 1.000 20.88653 ? 83  ILE A CB  1 
ATOM   557  C CG1 . ILE A 1 84  ? 16.97819 -5.67343  -18.65898 1.000 22.33934 ? 83  ILE A CG1 1 
ATOM   558  C CG2 . ILE A 1 84  ? 15.67819 -3.56471  -18.85465 1.000 18.92463 ? 83  ILE A CG2 1 
ATOM   559  C CD1 . ILE A 1 84  ? 17.45582 -5.50540  -17.22689 1.000 20.60221 ? 83  ILE A CD1 1 
ATOM   560  N N   . VAL A 1 85  ? 15.63437 -2.92008  -22.33560 1.000 20.16481 ? 84  VAL A N   1 
ATOM   561  C CA  . VAL A 1 85  ? 15.54904 -1.62460  -22.99820 1.000 16.73412 ? 84  VAL A CA  1 
ATOM   562  C C   . VAL A 1 85  ? 15.20103 -0.58314  -21.94063 1.000 17.26839 ? 84  VAL A C   1 
ATOM   563  O O   . VAL A 1 85  ? 14.27667 -0.78480  -21.14861 1.000 20.15705 ? 84  VAL A O   1 
ATOM   564  C CB  . VAL A 1 85  ? 14.50685 -1.65345  -24.13106 1.000 26.14831 ? 84  VAL A CB  1 
ATOM   565  C CG1 . VAL A 1 85  ? 14.25045 -0.24227  -24.65684 1.000 24.05229 ? 84  VAL A CG1 1 
ATOM   566  C CG2 . VAL A 1 85  ? 14.97773 -2.57289  -25.26079 1.000 22.20443 ? 84  VAL A CG2 1 
ATOM   567  N N   . LYS A 1 86  ? 15.93693 0.52858   -21.92238 1.000 15.97937 ? 85  LYS A N   1 
ATOM   568  C CA  . LYS A 1 86  ? 15.65613 1.65510   -21.03539 1.000 14.90308 ? 85  LYS A CA  1 
ATOM   569  C C   . LYS A 1 86  ? 15.09912 2.80253   -21.86088 1.000 16.47060 ? 85  LYS A C   1 
ATOM   570  O O   . LYS A 1 86  ? 15.79328 3.32005   -22.74154 1.000 18.47878 ? 85  LYS A O   1 
ATOM   571  C CB  . LYS A 1 86  ? 16.91159 2.12312   -20.29511 1.000 18.03843 ? 85  LYS A CB  1 
ATOM   572  C CG  . LYS A 1 86  ? 17.28025 1.26539   -19.10801 1.000 18.44285 ? 85  LYS A CG  1 
ATOM   573  C CD  . LYS A 1 86  ? 17.83062 -0.06716  -19.53717 1.000 17.05720 ? 85  LYS A CD  1 
ATOM   574  C CE  . LYS A 1 86  ? 19.06449 0.11029   -20.43637 1.000 15.65715 ? 85  LYS A CE  1 
ATOM   575  N NZ  . LYS A 1 86  ? 19.78345 -1.18313  -20.55236 1.000 16.18923 ? 85  LYS A NZ  1 
ATOM   576  N N   . GLY A 1 87  ? 13.85891 3.19492   -21.57747 1.000 17.34903 ? 86  GLY A N   1 
ATOM   577  C CA  . GLY A 1 87  ? 13.21910 4.29264   -22.28633 1.000 13.30928 ? 86  GLY A CA  1 
ATOM   578  C C   . GLY A 1 87  ? 13.29123 5.56521   -21.46267 1.000 17.51381 ? 86  GLY A C   1 
ATOM   579  O O   . GLY A 1 87  ? 12.97580 5.56202   -20.27004 1.000 16.41130 ? 86  GLY A O   1 
ATOM   580  N N   . PHE A 1 88  ? 13.71580 6.65240   -22.11656 1.000 16.07431 ? 87  PHE A N   1 
ATOM   581  C CA  . PHE A 1 88  ? 13.83442 7.97350   -21.50775 1.000 17.49882 ? 87  PHE A CA  1 
ATOM   582  C C   . PHE A 1 88  ? 12.99079 8.97504   -22.28380 1.000 17.36618 ? 87  PHE A C   1 
ATOM   583  O O   . PHE A 1 88  ? 12.64288 8.74184   -23.44342 1.000 16.06798 ? 87  PHE A O   1 
ATOM   584  C CB  . PHE A 1 88  ? 15.28631 8.48919   -21.52982 1.000 16.43080 ? 87  PHE A CB  1 
ATOM   585  C CG  . PHE A 1 88  ? 16.27854 7.61885   -20.81007 1.000 16.97402 ? 87  PHE A CG  1 
ATOM   586  C CD1 . PHE A 1 88  ? 16.76403 6.46024   -21.38782 1.000 17.43146 ? 87  PHE A CD1 1 
ATOM   587  C CD2 . PHE A 1 88  ? 16.77149 8.00401   -19.56642 1.000 17.90718 ? 87  PHE A CD2 1 
ATOM   588  C CE1 . PHE A 1 88  ? 17.72017 5.68078   -20.72608 1.000 17.43237 ? 87  PHE A CE1 1 
ATOM   589  C CE2 . PHE A 1 88  ? 17.71242 7.22331   -18.90292 1.000 18.36407 ? 87  PHE A CE2 1 
ATOM   590  C CZ  . PHE A 1 88  ? 18.18336 6.06961   -19.48721 1.000 19.80385 ? 87  PHE A CZ  1 
ATOM   591  N N   . HIS A 1 89  ? 12.71268 10.12716  -21.67328 1.000 19.44265 ? 88  HIS A N   1 
ATOM   592  C CA  . HIS A 1 89  ? 12.15469 11.24005  -22.44276 1.000 20.89915 ? 88  HIS A CA  1 
ATOM   593  C C   . HIS A 1 89  ? 13.16093 12.35332  -22.69911 1.000 24.25476 ? 88  HIS A C   1 
ATOM   594  O O   . HIS A 1 89  ? 12.83177 13.33565  -23.37727 1.000 25.01279 ? 88  HIS A O   1 
ATOM   595  C CB  . HIS A 1 89  ? 10.89132 11.80215  -21.77357 1.000 22.66005 ? 88  HIS A CB  1 
ATOM   596  C CG  . HIS A 1 89  ? 11.09533 12.32318  -20.38346 1.000 22.54745 ? 88  HIS A CG  1 
ATOM   597  N ND1 . HIS A 1 89  ? 11.26752 13.66423  -20.10750 1.000 28.46108 ? 88  HIS A ND1 1 
ATOM   598  C CD2 . HIS A 1 89  ? 11.10347 11.68887  -19.18599 1.000 27.51085 ? 88  HIS A CD2 1 
ATOM   599  C CE1 . HIS A 1 89  ? 11.39091 13.83016  -18.80243 1.000 28.94196 ? 88  HIS A CE1 1 
ATOM   600  N NE2 . HIS A 1 89  ? 11.28965 12.64808  -18.22023 1.000 25.16331 ? 88  HIS A NE2 1 
ATOM   601  N N   . HIS A 1 90  ? 14.37215 12.22520  -22.17199 1.000 20.37601 ? 89  HIS A N   1 
ATOM   602  C CA  . HIS A 1 90  ? 15.51745 13.03074  -22.56836 1.000 21.67394 ? 89  HIS A CA  1 
ATOM   603  C C   . HIS A 1 90  ? 16.77268 12.27669  -22.16441 1.000 18.81472 ? 89  HIS A C   1 
ATOM   604  O O   . HIS A 1 90  ? 17.45153 12.62163  -21.19237 1.000 17.89410 ? 89  HIS A O   1 
ATOM   605  C CB  . HIS A 1 90  ? 15.42550 14.46018  -22.01316 1.000 20.01116 ? 89  HIS A CB  1 
ATOM   606  C CG  . HIS A 1 90  ? 15.15176 14.54813  -20.53715 1.000 23.47185 ? 89  HIS A CG  1 
ATOM   607  N ND1 . HIS A 1 90  ? 14.49111 15.62224  -19.98282 1.000 32.60070 ? 89  HIS A ND1 1 
ATOM   608  C CD2 . HIS A 1 90  ? 15.37312 13.67976  -19.51920 1.000 23.95691 ? 89  HIS A CD2 1 
ATOM   609  C CE1 . HIS A 1 90  ? 14.35725 15.43281  -18.67888 1.000 29.05656 ? 89  HIS A CE1 1 
ATOM   610  N NE2 . HIS A 1 90  ? 14.88482 14.26208  -18.37267 1.000 27.58964 ? 89  HIS A NE2 1 
ATOM   611  N N   . ALA A 1 91  ? 17.07361 11.23625  -22.94881 1.000 16.03689 ? 90  ALA A N   1 
ATOM   612  C CA  . ALA A 1 91  ? 18.13603 10.29360  -22.60878 1.000 17.11469 ? 90  ALA A CA  1 
ATOM   613  C C   . ALA A 1 91  ? 19.50076 10.96662  -22.52652 1.000 17.43915 ? 90  ALA A C   1 
ATOM   614  O O   . ALA A 1 91  ? 20.28961 10.65020  -21.63015 1.000 16.41765 ? 90  ALA A O   1 
ATOM   615  C CB  . ALA A 1 91  ? 18.17501 9.15133   -23.62287 1.000 17.96078 ? 90  ALA A CB  1 
ATOM   616  N N   . VAL A 1 92  ? 19.83063 11.85963  -23.46726 1.000 16.38852 ? 91  VAL A N   1 
ATOM   617  C CA  . VAL A 1 92  ? 21.17887 12.43841  -23.42921 1.000 18.73071 ? 91  VAL A CA  1 
ATOM   618  C C   . VAL A 1 92  ? 21.39979 13.19210  -22.11455 1.000 21.09826 ? 91  VAL A C   1 
ATOM   619  O O   . VAL A 1 92  ? 22.47346 13.11516  -21.49724 1.000 18.14697 ? 91  VAL A O   1 
ATOM   620  C CB  . VAL A 1 92  ? 21.41082 13.34270  -24.64468 1.000 20.83471 ? 91  VAL A CB  1 
ATOM   621  C CG1 . VAL A 1 92  ? 22.73141 14.07048  -24.48696 1.000 22.18251 ? 91  VAL A CG1 1 
ATOM   622  C CG2 . VAL A 1 92  ? 21.39616 12.49437  -25.92415 1.000 16.18773 ? 91  VAL A CG2 1 
ATOM   623  N N   . PHE A 1 93  ? 20.37598 13.92098  -21.67288 1.000 19.28697 ? 92  PHE A N   1 
ATOM   624  C CA  . PHE A 1 93  ? 20.41620 14.66226  -20.41695 1.000 22.68650 ? 92  PHE A CA  1 
ATOM   625  C C   . PHE A 1 93  ? 20.59102 13.72240  -19.22669 1.000 17.52130 ? 92  PHE A C   1 
ATOM   626  O O   . PHE A 1 93  ? 21.53565 13.86426  -18.44208 1.000 17.57669 ? 92  PHE A O   1 
ATOM   627  C CB  . PHE A 1 93  ? 19.12324 15.47416  -20.30251 1.000 20.26177 ? 92  PHE A CB  1 
ATOM   628  C CG  . PHE A 1 93  ? 18.99569 16.28282  -19.03748 1.000 23.42642 ? 92  PHE A CG  1 
ATOM   629  C CD1 . PHE A 1 93  ? 19.49939 17.56905  -18.96996 1.000 25.23890 ? 92  PHE A CD1 1 
ATOM   630  C CD2 . PHE A 1 93  ? 18.33017 15.76433  -17.93749 1.000 26.01199 ? 92  PHE A CD2 1 
ATOM   631  C CE1 . PHE A 1 93  ? 19.35494 18.32420  -17.82076 1.000 26.37187 ? 92  PHE A CE1 1 
ATOM   632  C CE2 . PHE A 1 93  ? 18.19214 16.50796  -16.76557 1.000 28.97813 ? 92  PHE A CE2 1 
ATOM   633  C CZ  . PHE A 1 93  ? 18.70390 17.79294  -16.71272 1.000 27.02277 ? 92  PHE A CZ  1 
ATOM   634  N N   . ASP A 1 94  ? 19.69200 12.73916  -19.08943 1.000 18.19189 ? 93  ASP A N   1 
ATOM   635  C CA  . ASP A 1 94  ? 19.71650 11.86263  -17.91510 1.000 17.03923 ? 93  ASP A CA  1 
ATOM   636  C C   . ASP A 1 94  ? 20.98111 11.01563  -17.88922 1.000 18.29443 ? 93  ASP A C   1 
ATOM   637  O O   . ASP A 1 94  ? 21.61342 10.85075  -16.84186 1.000 17.83978 ? 93  ASP A O   1 
ATOM   638  C CB  . ASP A 1 94  ? 18.49719 10.94557  -17.90578 1.000 19.36982 ? 93  ASP A CB  1 
ATOM   639  C CG  . ASP A 1 94  ? 17.21024 11.68007  -17.58785 1.000 23.57061 ? 93  ASP A CG  1 
ATOM   640  O OD1 . ASP A 1 94  ? 17.24498 12.70788  -16.88019 1.000 24.33400 ? 93  ASP A OD1 1 
ATOM   641  O OD2 . ASP A 1 94  ? 16.16074 11.20602  -18.03701 1.000 30.03654 ? 93  ASP A OD2 1 
ATOM   642  N N   . LEU A 1 95  ? 21.34064 10.44001  -19.03489 1.000 16.87424 ? 94  LEU A N   1 
ATOM   643  C CA  . LEU A 1 95  ? 22.53046 9.60082   -19.10020 1.000 16.51981 ? 94  LEU A CA  1 
ATOM   644  C C   . LEU A 1 95  ? 23.79418 10.40350  -18.85831 1.000 17.19442 ? 94  LEU A C   1 
ATOM   645  O O   . LEU A 1 95  ? 24.79175 9.84476   -18.39538 1.000 19.28343 ? 94  LEU A O   1 
ATOM   646  C CB  . LEU A 1 95  ? 22.61471 8.91396   -20.46297 1.000 14.69179 ? 94  LEU A CB  1 
ATOM   647  C CG  . LEU A 1 95  ? 21.56060 7.82634   -20.65333 1.000 18.37905 ? 94  LEU A CG  1 
ATOM   648  C CD1 . LEU A 1 95  ? 21.56321 7.34234   -22.09118 1.000 22.43211 ? 94  LEU A CD1 1 
ATOM   649  C CD2 . LEU A 1 95  ? 21.81358 6.65552   -19.69099 1.000 21.18398 ? 94  LEU A CD2 1 
ATOM   650  N N   . GLY A 1 96  ? 23.79217 11.68997  -19.22426 1.000 15.67828 ? 95  GLY A N   1 
ATOM   651  C CA  . GLY A 1 96  ? 24.92256 12.53601  -18.89565 1.000 16.68351 ? 95  GLY A CA  1 
ATOM   652  C C   . GLY A 1 96  ? 25.13732 12.61799  -17.39462 1.000 18.31168 ? 95  GLY A C   1 
ATOM   653  O O   . GLY A 1 96  ? 26.26918 12.51620  -16.90972 1.000 18.86214 ? 95  GLY A O   1 
ATOM   654  N N   . PHE A 1 97  ? 24.04800 12.76853  -16.63754 1.000 15.47500 ? 96  PHE A N   1 
ATOM   655  C CA  . PHE A 1 97  ? 24.16604 12.75484  -15.18010 1.000 18.67452 ? 96  PHE A CA  1 
ATOM   656  C C   . PHE A 1 97  ? 24.66612 11.40665  -14.67508 1.000 18.40879 ? 96  PHE A C   1 
ATOM   657  O O   . PHE A 1 97  ? 25.54206 11.34752  -13.80104 1.000 18.86200 ? 96  PHE A O   1 
ATOM   658  C CB  . PHE A 1 97  ? 22.82265 13.10011  -14.53544 1.000 19.08200 ? 96  PHE A CB  1 
ATOM   659  C CG  . PHE A 1 97  ? 22.57388 14.57333  -14.41018 1.000 19.02525 ? 96  PHE A CG  1 
ATOM   660  C CD1 . PHE A 1 97  ? 23.07814 15.27817  -13.30801 1.000 22.01791 ? 96  PHE A CD1 1 
ATOM   661  C CD2 . PHE A 1 97  ? 21.83109 15.25417  -15.35632 1.000 20.13048 ? 96  PHE A CD2 1 
ATOM   662  C CE1 . PHE A 1 97  ? 22.85336 16.63990  -13.17686 1.000 21.88208 ? 96  PHE A CE1 1 
ATOM   663  C CE2 . PHE A 1 97  ? 21.58946 16.62629  -15.22662 1.000 23.48087 ? 96  PHE A CE2 1 
ATOM   664  C CZ  . PHE A 1 97  ? 22.11021 17.31919  -14.13117 1.000 19.15960 ? 96  PHE A CZ  1 
ATOM   665  N N   . LEU A 1 98  ? 24.11664 10.30750  -15.20373 1.000 18.55759 ? 97  LEU A N   1 
ATOM   666  C CA  . LEU A 1 98  ? 24.51186 8.98549   -14.72179 1.000 17.87275 ? 97  LEU A CA  1 
ATOM   667  C C   . LEU A 1 98  ? 25.95259 8.67084   -15.10282 1.000 20.08093 ? 97  LEU A C   1 
ATOM   668  O O   . LEU A 1 98  ? 26.67677 8.00727   -14.34607 1.000 19.64511 ? 97  LEU A O   1 
ATOM   669  C CB  . LEU A 1 98  ? 23.55925 7.92954   -15.27674 1.000 19.03975 ? 97  LEU A CB  1 
ATOM   670  C CG  . LEU A 1 98  ? 22.10911 8.03515   -14.77137 1.000 21.74300 ? 97  LEU A CG  1 
ATOM   671  C CD1 . LEU A 1 98  ? 21.10920 7.41627   -15.74767 1.000 24.30097 ? 97  LEU A CD1 1 
ATOM   672  C CD2 . LEU A 1 98  ? 21.99223 7.38750   -13.38104 1.000 21.76771 ? 97  LEU A CD2 1 
ATOM   673  N N   . ARG A 1 99  ? 26.36744 9.11455   -16.28934 1.000 17.30548 ? 98  ARG A N   1 
ATOM   674  C CA  . ARG A 1 99  ? 27.75400 8.95759   -16.72054 1.000 18.06825 ? 98  ARG A CA  1 
ATOM   675  C C   . ARG A 1 99  ? 28.70952 9.73734   -15.82874 1.000 21.46544 ? 98  ARG A C   1 
ATOM   676  O O   . ARG A 1 99  ? 29.76230 9.22829   -15.43441 1.000 23.41804 ? 98  ARG A O   1 
ATOM   677  C CB  . ARG A 1 99  ? 27.89795 9.41966   -18.16531 1.000 19.26615 ? 98  ARG A CB  1 
ATOM   678  C CG  . ARG A 1 99  ? 29.32232 9.37425   -18.67433 1.000 20.74811 ? 98  ARG A CG  1 
ATOM   679  C CD  . ARG A 1 99  ? 29.87841 7.98464   -18.60329 1.000 21.84805 ? 98  ARG A CD  1 
ATOM   680  N NE  . ARG A 1 99  ? 31.23554 7.94254   -19.12974 1.000 21.99645 ? 98  ARG A NE  1 
ATOM   681  C CZ  . ARG A 1 99  ? 32.31699 8.32648   -18.46316 1.000 25.14852 ? 98  ARG A CZ  1 
ATOM   682  N NH1 . ARG A 1 99  ? 32.25239 8.70923   -17.18656 1.000 25.28806 ? 98  ARG A NH1 1 
ATOM   683  N NH2 . ARG A 1 99  ? 33.49513 8.30998   -19.08209 1.000 26.81082 ? 98  ARG A NH2 1 
ATOM   684  N N   . HIS A 1 100 ? 28.37556 10.98898  -15.51984 1.000 20.09951 ? 99  HIS A N   1 
ATOM   685  C CA  . HIS A 1 100 ? 29.32118 11.80656  -14.76650 1.000 23.26842 ? 99  HIS A CA  1 
ATOM   686  C C   . HIS A 1 100 ? 29.36299 11.38043  -13.30568 1.000 24.19728 ? 99  HIS A C   1 
ATOM   687  O O   . HIS A 1 100 ? 30.43161 11.38479  -12.67714 1.000 26.04382 ? 99  HIS A O   1 
ATOM   688  C CB  . HIS A 1 100 ? 28.95616 13.28525  -14.87169 1.000 21.95052 ? 99  HIS A CB  1 
ATOM   689  C CG  . HIS A 1 100 ? 30.02699 14.19468  -14.35921 1.000 27.82023 ? 99  HIS A CG  1 
ATOM   690  N ND1 . HIS A 1 100 ? 31.19826 14.42070  -15.05140 1.000 30.34148 ? 99  HIS A ND1 1 
ATOM   691  C CD2 . HIS A 1 100 ? 30.13502 14.88569  -13.19778 1.000 29.33005 ? 99  HIS A CD2 1 
ATOM   692  C CE1 . HIS A 1 100 ? 31.96737 15.23939  -14.35476 1.000 33.88537 ? 99  HIS A CE1 1 
ATOM   693  N NE2 . HIS A 1 100 ? 31.34674 15.53529  -13.22649 1.000 28.25792 ? 99  HIS A NE2 1 
ATOM   694  N N   . THR A 1 101 ? 28.20867 10.98953  -12.75812 1.000 22.18865 ? 100 THR A N   1 
ATOM   695  C CA  . THR A 1 101 ? 28.09731 10.70742  -11.32850 1.000 23.78726 ? 100 THR A CA  1 
ATOM   696  C C   . THR A 1 101 ? 28.62630 9.31515   -10.98825 1.000 27.60118 ? 100 THR A C   1 
ATOM   697  O O   . THR A 1 101 ? 29.37066 9.14414   -10.01300 1.000 25.36484 ? 100 THR A O   1 
ATOM   698  C CB  . THR A 1 101 ? 26.63556 10.84465  -10.89179 1.000 24.74226 ? 100 THR A CB  1 
ATOM   699  O OG1 . THR A 1 101 ? 26.16208 12.15975  -11.19926 1.000 25.95506 ? 100 THR A OG1 1 
ATOM   700  C CG2 . THR A 1 101 ? 26.49236 10.61931  -9.36929  1.000 22.71919 ? 100 THR A CG2 1 
ATOM   701  N N   . PHE A 1 102 ? 28.24375 8.30216   -11.77035 1.000 24.03639 ? 101 PHE A N   1 
ATOM   702  C CA  . PHE A 1 102 ? 28.56994 6.91603   -11.46184 1.000 25.03793 ? 101 PHE A CA  1 
ATOM   703  C C   . PHE A 1 102 ? 29.50838 6.25170   -12.46014 1.000 26.58695 ? 101 PHE A C   1 
ATOM   704  O O   . PHE A 1 102 ? 29.74829 5.04718   -12.33778 1.000 24.79574 ? 101 PHE A O   1 
ATOM   705  C CB  . PHE A 1 102 ? 27.29689 6.06350   -11.36814 1.000 28.03624 ? 101 PHE A CB  1 
ATOM   706  C CG  . PHE A 1 102 ? 26.26120 6.58841   -10.40708 1.000 27.09642 ? 101 PHE A CG  1 
ATOM   707  C CD1 . PHE A 1 102 ? 26.56069 6.75825   -9.06146  1.000 31.87451 ? 101 PHE A CD1 1 
ATOM   708  C CD2 . PHE A 1 102 ? 24.96974 6.84360   -10.83792 1.000 31.82814 ? 101 PHE A CD2 1 
ATOM   709  C CE1 . PHE A 1 102 ? 25.59953 7.21863   -8.17126  1.000 33.21915 ? 101 PHE A CE1 1 
ATOM   710  C CE2 . PHE A 1 102 ? 24.00167 7.30142   -9.95398  1.000 33.31640 ? 101 PHE A CE2 1 
ATOM   711  C CZ  . PHE A 1 102 ? 24.31426 7.48544   -8.61998  1.000 30.51111 ? 101 PHE A CZ  1 
ATOM   712  N N   . GLN A 1 103 ? 30.02133 6.97889   -13.45112 1.000 23.22544 ? 102 GLN A N   1 
ATOM   713  C CA  . GLN A 1 103 ? 30.75484 6.37546   -14.57134 1.000 27.51328 ? 102 GLN A CA  1 
ATOM   714  C C   . GLN A 1 103 ? 29.92350 5.31577   -15.29337 1.000 25.29148 ? 102 GLN A C   1 
ATOM   715  O O   . GLN A 1 103 ? 30.46177 4.33831   -15.81370 1.000 31.98268 ? 102 GLN A O   1 
ATOM   716  C CB  . GLN A 1 103 ? 32.09832 5.78396   -14.11811 1.000 28.79114 ? 102 GLN A CB  1 
ATOM   717  C CG  . GLN A 1 103 ? 33.20882 6.79936   -13.85294 1.000 35.34069 ? 102 GLN A CG  1 
ATOM   718  C CD  . GLN A 1 103 ? 32.76752 8.01464   -13.06349 1.000 38.15010 ? 102 GLN A CD  1 
ATOM   719  O OE1 . GLN A 1 103 ? 32.87127 9.14380   -13.54705 1.000 49.28497 ? 102 GLN A OE1 1 
ATOM   720  N NE2 . GLN A 1 103 ? 32.28640 7.79735   -11.84129 1.000 47.72175 ? 102 GLN A NE2 1 
ATOM   721  N N   . SER A 1 104 ? 28.60641 5.49920   -15.34877 1.000 25.26399 ? 103 SER A N   1 
ATOM   722  C CA  . SER A 1 104 ? 27.73673 4.48091   -15.91506 1.000 23.38889 ? 103 SER A CA  1 
ATOM   723  C C   . SER A 1 104 ? 27.70889 4.60083   -17.43156 1.000 23.64201 ? 103 SER A C   1 
ATOM   724  O O   . SER A 1 104 ? 27.46888 5.68288   -17.96982 1.000 24.76484 ? 103 SER A O   1 
ATOM   725  C CB  . SER A 1 104 ? 26.32321 4.60839   -15.35664 1.000 25.90187 ? 103 SER A CB  1 
ATOM   726  O OG  . SER A 1 104 ? 25.39991 3.92770   -16.19361 1.000 32.33193 ? 103 SER A OG  1 
ATOM   727  N N   . LYS A 1 105 ? 27.94552 3.49318   -18.11474 1.000 24.23936 ? 104 LYS A N   1 
ATOM   728  C CA  . LYS A 1 105 ? 27.82632 3.43521   -19.56947 1.000 29.27450 ? 104 LYS A CA  1 
ATOM   729  C C   . LYS A 1 105 ? 26.63942 2.54416   -19.92154 1.000 31.04850 ? 104 LYS A C   1 
ATOM   730  O O   . LYS A 1 105 ? 26.68867 1.32401   -19.72998 1.000 35.59979 ? 104 LYS A O   1 
ATOM   731  C CB  . LYS A 1 105 ? 29.11074 2.91175   -20.19907 1.000 33.00283 ? 104 LYS A CB  1 
ATOM   732  C CG  . LYS A 1 105 ? 30.25855 3.90083   -20.16922 1.000 29.89949 ? 104 LYS A CG  1 
ATOM   733  C CD  . LYS A 1 105 ? 31.54569 3.21192   -20.58288 1.000 38.46172 ? 104 LYS A CD  1 
ATOM   734  C CE  . LYS A 1 105 ? 32.72609 4.17040   -20.53622 1.000 42.13579 ? 104 LYS A CE  1 
ATOM   735  N NZ  . LYS A 1 105 ? 32.99424 4.61080   -19.14584 1.000 49.18108 ? 104 LYS A NZ  1 
ATOM   736  N N   . ALA A 1 106 ? 25.58739 3.14573   -20.45547 1.000 23.21523 ? 105 ALA A N   1 
ATOM   737  C CA  . ALA A 1 106 ? 24.36310 2.40984   -20.71292 1.000 21.66533 ? 105 ALA A CA  1 
ATOM   738  C C   . ALA A 1 106 ? 24.41296 1.71294   -22.07636 1.000 22.85772 ? 105 ALA A C   1 
ATOM   739  O O   . ALA A 1 106 ? 25.19463 2.06877   -22.96272 1.000 19.90803 ? 105 ALA A O   1 
ATOM   740  C CB  . ALA A 1 106 ? 23.15493 3.35025   -20.64467 1.000 20.62396 ? 105 ALA A CB  1 
ATOM   741  N N   . ARG A 1 107 ? 23.57017 0.69141   -22.21856 1.000 19.17940 ? 106 ARG A N   1 
ATOM   742  C CA  . ARG A 1 107 ? 23.31223 0.03499   -23.49098 1.000 19.80652 ? 106 ARG A CA  1 
ATOM   743  C C   . ARG A 1 107 ? 21.80535 -0.10806  -23.66201 1.000 21.73304 ? 106 ARG A C   1 
ATOM   744  O O   . ARG A 1 107 ? 21.05620 -0.10324  -22.68528 1.000 17.49758 ? 106 ARG A O   1 
ATOM   745  C CB  . ARG A 1 107 ? 24.00397 -1.34026  -23.56365 1.000 24.16930 ? 106 ARG A CB  1 
ATOM   746  C CG  . ARG A 1 107 ? 25.52167 -1.23508  -23.42919 1.000 28.63791 ? 106 ARG A CG  1 
ATOM   747  C CD  . ARG A 1 107 ? 26.23702 -2.54634  -23.68095 1.000 37.64602 ? 106 ARG A CD  1 
ATOM   748  N NE  . ARG A 1 107 ? 25.98325 -3.53039  -22.63599 1.000 39.72852 ? 106 ARG A NE  1 
ATOM   749  C CZ  . ARG A 1 107 ? 26.81280 -3.82332  -21.64239 1.000 41.22755 ? 106 ARG A CZ  1 
ATOM   750  N NH1 . ARG A 1 107 ? 27.93719 -3.15144  -21.45450 1.000 48.72372 ? 106 ARG A NH1 1 
ATOM   751  N NH2 . ARG A 1 107 ? 26.50196 -4.81498  -20.81265 1.000 45.27747 ? 106 ARG A NH2 1 
ATOM   752  N N   . SER A 1 108 ? 21.36108 -0.21712  -24.92426 1.000 16.98336 ? 107 SER A N   1 
ATOM   753  C CA  . SER A 1 108 ? 19.94004 -0.42701  -25.24968 1.000 17.87271 ? 107 SER A CA  1 
ATOM   754  C C   . SER A 1 108 ? 19.05131 0.65953   -24.64010 1.000 18.62876 ? 107 SER A C   1 
ATOM   755  O O   . SER A 1 108 ? 18.08122 0.37869   -23.92151 1.000 18.82457 ? 107 SER A O   1 
ATOM   756  C CB  . SER A 1 108 ? 19.46322 -1.81481  -24.80880 1.000 19.19647 ? 107 SER A CB  1 
ATOM   757  O OG  . SER A 1 108 ? 20.15754 -2.84510  -25.47488 1.000 22.88336 ? 107 SER A OG  1 
ATOM   758  N N   . VAL A 1 109 ? 19.38738 1.91411   -24.92377 1.000 16.50016 ? 108 VAL A N   1 
ATOM   759  C CA  . VAL A 1 109 ? 18.57102 3.04730   -24.50246 1.000 17.10550 ? 108 VAL A CA  1 
ATOM   760  C C   . VAL A 1 109 ? 17.75403 3.54740   -25.68642 1.000 18.30736 ? 108 VAL A C   1 
ATOM   761  O O   . VAL A 1 109 ? 18.20962 3.50311   -26.83698 1.000 17.67469 ? 108 VAL A O   1 
ATOM   762  C CB  . VAL A 1 109 ? 19.43418 4.17698   -23.90728 1.000 18.93135 ? 108 VAL A CB  1 
ATOM   763  C CG1 . VAL A 1 109 ? 20.26995 3.65739   -22.73477 1.000 19.74041 ? 108 VAL A CG1 1 
ATOM   764  C CG2 . VAL A 1 109 ? 20.32222 4.80109   -24.95839 1.000 21.09102 ? 108 VAL A CG2 1 
ATOM   765  N N   . VAL A 1 110 ? 16.52734 3.99242   -25.41560 1.000 15.92499 ? 109 VAL A N   1 
ATOM   766  C CA  . VAL A 1 110 ? 15.71442 4.67208   -26.41615 1.000 15.82559 ? 109 VAL A CA  1 
ATOM   767  C C   . VAL A 1 110 ? 15.21356 5.96640   -25.79317 1.000 17.75492 ? 109 VAL A C   1 
ATOM   768  O O   . VAL A 1 110 ? 15.20445 6.13127   -24.57128 1.000 16.31059 ? 109 VAL A O   1 
ATOM   769  C CB  . VAL A 1 110 ? 14.53358 3.81600   -26.93644 1.000 19.64189 ? 109 VAL A CB  1 
ATOM   770  C CG1 . VAL A 1 110 ? 15.04494 2.50997   -27.54075 1.000 16.31462 ? 109 VAL A CG1 1 
ATOM   771  C CG2 . VAL A 1 110 ? 13.52286 3.54779   -25.83120 1.000 19.17410 ? 109 VAL A CG2 1 
ATOM   772  N N   . CYS A 1 111 ? 14.82208 6.90487   -26.65103 1.000 15.89997 ? 110 CYS A N   1 
ATOM   773  C CA  . CYS A 1 111 ? 14.50109 8.25279   -26.19820 1.000 14.85713 ? 110 CYS A CA  1 
ATOM   774  C C   . CYS A 1 111 ? 13.33151 8.80193   -26.99448 1.000 15.09947 ? 110 CYS A C   1 
ATOM   775  O O   . CYS A 1 111 ? 13.37088 8.81848   -28.23037 1.000 14.47439 ? 110 CYS A O   1 
ATOM   776  C CB  . CYS A 1 111 ? 15.69948 9.19545   -26.35305 1.000 16.02357 ? 110 CYS A CB  1 
ATOM   777  S SG  . CYS A 1 111 ? 15.36369 10.88047  -25.77897 1.000 17.77471 ? 110 CYS A SG  1 
ATOM   778  N N   . SER A 1 112 ? 12.29875 9.26847   -26.28458 1.000 16.76247 ? 111 SER A N   1 
ATOM   779  C CA  . SER A 1 112 ? 11.16813 9.87257   -26.98096 1.000 16.72362 ? 111 SER A CA  1 
ATOM   780  C C   . SER A 1 112 ? 11.53377 11.21346  -27.60122 1.000 16.63901 ? 111 SER A C   1 
ATOM   781  O O   . SER A 1 112 ? 10.92482 11.61022  -28.59718 1.000 17.55029 ? 111 SER A O   1 
ATOM   782  C CB  . SER A 1 112 ? 9.98232  10.03111  -26.02574 1.000 18.12836 ? 111 SER A CB  1 
ATOM   783  O OG  . SER A 1 112 ? 10.30611 10.90306  -24.93410 1.000 16.09350 ? 111 SER A OG  1 
ATOM   784  N N   . LYS A 1 113 ? 12.50505 11.93006  -27.02571 1.000 15.04886 ? 112 LYS A N   1 
ATOM   785  C CA  . LYS A 1 113 ? 12.89827 13.21462  -27.59693 1.000 15.55427 ? 112 LYS A CA  1 
ATOM   786  C C   . LYS A 1 113 ? 13.60834 13.01825  -28.92430 1.000 17.93882 ? 112 LYS A C   1 
ATOM   787  O O   . LYS A 1 113 ? 13.31036 13.72200  -29.90147 1.000 17.98251 ? 112 LYS A O   1 
ATOM   788  C CB  . LYS A 1 113 ? 13.79513 13.98978  -26.62777 1.000 20.46080 ? 112 LYS A CB  1 
ATOM   789  C CG  . LYS A 1 113 ? 14.17424 15.37366  -27.14496 1.000 22.68010 ? 112 LYS A CG  1 
ATOM   790  C CD  . LYS A 1 113 ? 14.96217 16.19804  -26.11524 1.000 26.65279 ? 112 LYS A CD  1 
ATOM   791  C CE  . LYS A 1 113 ? 14.15023 16.45480  -24.87192 1.000 30.34973 ? 112 LYS A CE  1 
ATOM   792  N NZ  . LYS A 1 113 ? 13.00425 17.35599  -25.19929 1.000 37.24798 ? 112 LYS A NZ  1 
ATOM   793  N N   . VAL A 1 114 ? 14.53505 12.05267  -28.98573 1.000 15.58550 ? 113 VAL A N   1 
ATOM   794  C CA  . VAL A 1 114 ? 15.18444 11.73552  -30.26121 1.000 15.97784 ? 113 VAL A CA  1 
ATOM   795  C C   . VAL A 1 114 ? 14.14278 11.34105  -31.30015 1.000 16.32139 ? 113 VAL A C   1 
ATOM   796  O O   . VAL A 1 114 ? 14.19089 11.78938  -32.44870 1.000 16.77591 ? 113 VAL A O   1 
ATOM   797  C CB  . VAL A 1 114 ? 16.23813 10.62532  -30.07668 1.000 15.71681 ? 113 VAL A CB  1 
ATOM   798  C CG1 . VAL A 1 114 ? 16.75307 10.14630  -31.44935 1.000 17.74331 ? 113 VAL A CG1 1 
ATOM   799  C CG2 . VAL A 1 114 ? 17.38755 11.12872  -29.22743 1.000 16.96130 ? 113 VAL A CG2 1 
ATOM   800  N N   . ALA A 1 115 ? 13.20530 10.47046  -30.92234 1.000 15.58913 ? 114 ALA A N   1 
ATOM   801  C CA  . ALA A 1 115 ? 12.16234 10.03897  -31.85491 1.000 17.38829 ? 114 ALA A CA  1 
ATOM   802  C C   . ALA A 1 115 ? 11.33718 11.21970  -32.35031 1.000 16.74850 ? 114 ALA A C   1 
ATOM   803  O O   . ALA A 1 115 ? 11.06992 11.34482  -33.55356 1.000 16.59897 ? 114 ALA A O   1 
ATOM   804  C CB  . ALA A 1 115 ? 11.25754 9.00514   -31.17894 1.000 18.43777 ? 114 ALA A CB  1 
ATOM   805  N N   . ALA A 1 116 ? 10.88140 12.07188  -31.42104 1.000 17.53234 ? 115 ALA A N   1 
ATOM   806  C CA  . ALA A 1 116 ? 10.08905 13.24336  -31.78628 1.000 17.25015 ? 115 ALA A CA  1 
ATOM   807  C C   . ALA A 1 116 ? 10.88439 14.21613  -32.64822 1.000 18.99382 ? 115 ALA A C   1 
ATOM   808  O O   . ALA A 1 116 ? 10.31046 14.89490  -33.50773 1.000 17.75202 ? 115 ALA A O   1 
ATOM   809  C CB  . ALA A 1 116 ? 9.58222  13.94026  -30.51925 1.000 16.16661 ? 115 ALA A CB  1 
ATOM   810  N N   . LYS A 1 117 ? 12.20014 14.30164  -32.43760 1.000 17.06894 ? 116 LYS A N   1 
ATOM   811  C CA  . LYS A 1 117 ? 13.01875 15.16731  -33.28572 1.000 17.34744 ? 116 LYS A CA  1 
ATOM   812  C C   . LYS A 1 117 ? 13.14200 14.61215  -34.69675 1.000 18.08560 ? 116 LYS A C   1 
ATOM   813  O O   . LYS A 1 117 ? 13.36493 15.37288  -35.64503 1.000 20.73560 ? 116 LYS A O   1 
ATOM   814  C CB  . LYS A 1 117 ? 14.40624 15.35062  -32.67135 1.000 18.90319 ? 116 LYS A CB  1 
ATOM   815  C CG  . LYS A 1 117 ? 14.45667 16.46221  -31.61294 1.000 22.23670 ? 116 LYS A CG  1 
ATOM   816  C CD  . LYS A 1 117 ? 15.78542 16.47590  -30.90135 1.000 22.88928 ? 116 LYS A CD  1 
ATOM   817  C CE  . LYS A 1 117 ? 15.77176 17.47313  -29.75348 1.000 24.44014 ? 116 LYS A CE  1 
ATOM   818  N NZ  . LYS A 1 117 ? 15.46760 18.83836  -30.26699 1.000 29.80796 ? 116 LYS A NZ  1 
ATOM   819  N N   . ILE A 1 118 ? 13.01986 13.29809  -34.85532 1.000 18.28320 ? 117 ILE A N   1 
ATOM   820  C CA  . ILE A 1 118 ? 13.03806 12.71471  -36.19150 1.000 19.48527 ? 117 ILE A CA  1 
ATOM   821  C C   . ILE A 1 118 ? 11.68426 12.90554  -36.86705 1.000 20.62446 ? 117 ILE A C   1 
ATOM   822  O O   . ILE A 1 118 ? 11.60586 13.21728  -38.06036 1.000 19.59077 ? 117 ILE A O   1 
ATOM   823  C CB  . ILE A 1 118 ? 13.43782 11.23069  -36.10378 1.000 17.40303 ? 117 ILE A CB  1 
ATOM   824  C CG1 . ILE A 1 118 ? 14.91892 11.11217  -35.71931 1.000 21.08867 ? 117 ILE A CG1 1 
ATOM   825  C CG2 . ILE A 1 118 ? 13.09393 10.47342  -37.42282 1.000 17.32362 ? 117 ILE A CG2 1 
ATOM   826  C CD1 . ILE A 1 118 ? 15.36382 9.71731   -35.36611 1.000 21.69672 ? 117 ILE A CD1 1 
ATOM   827  N N   . LEU A 1 119 ? 10.60042 12.75501  -36.10472 1.000 18.46754 ? 118 LEU A N   1 
ATOM   828  C CA  . LEU A 1 119 ? 9.25679  12.85857  -36.67066 1.000 20.97321 ? 118 LEU A CA  1 
ATOM   829  C C   . LEU A 1 119 ? 8.85384  14.30488  -36.92747 1.000 21.07343 ? 118 LEU A C   1 
ATOM   830  O O   . LEU A 1 119 ? 8.24910  14.61095  -37.96590 1.000 20.89737 ? 118 LEU A O   1 
ATOM   831  C CB  . LEU A 1 119 ? 8.24376  12.19874  -35.72315 1.000 19.77781 ? 118 LEU A CB  1 
ATOM   832  C CG  . LEU A 1 119 ? 8.34203  10.67969  -35.61058 1.000 18.64395 ? 118 LEU A CG  1 
ATOM   833  C CD1 . LEU A 1 119 ? 7.56917  10.19446  -34.38134 1.000 20.43985 ? 118 LEU A CD1 1 
ATOM   834  C CD2 . LEU A 1 119 ? 7.84122  9.98310   -36.87485 1.000 19.58421 ? 118 LEU A CD2 1 
ATOM   835  N N   . TRP A 1 120 ? 9.14313  15.19282  -35.97983 1.000 19.31367 ? 119 TRP A N   1 
ATOM   836  C CA  . TRP A 1 120 ? 8.69488  16.58571  -36.01124 1.000 22.23151 ? 119 TRP A CA  1 
ATOM   837  C C   . TRP A 1 120 ? 9.87955  17.48973  -35.69838 1.000 20.29273 ? 119 TRP A C   1 
ATOM   838  O O   . TRP A 1 120 ? 9.94327  18.10831  -34.62853 1.000 24.24908 ? 119 TRP A O   1 
ATOM   839  C CB  . TRP A 1 120 ? 7.55497  16.80681  -35.01578 1.000 20.99592 ? 119 TRP A CB  1 
ATOM   840  C CG  . TRP A 1 120 ? 6.39491  15.90831  -35.26048 1.000 20.82825 ? 119 TRP A CG  1 
ATOM   841  C CD1 . TRP A 1 120 ? 5.58328  15.88244  -36.36650 1.000 21.67639 ? 119 TRP A CD1 1 
ATOM   842  C CD2 . TRP A 1 120 ? 5.92714  14.87183  -34.39456 1.000 19.79157 ? 119 TRP A CD2 1 
ATOM   843  N NE1 . TRP A 1 120 ? 4.62048  14.90693  -36.22279 1.000 24.12583 ? 119 TRP A NE1 1 
ATOM   844  C CE2 . TRP A 1 120 ? 4.81274  14.27119  -35.02002 1.000 23.30988 ? 119 TRP A CE2 1 
ATOM   845  C CE3 . TRP A 1 120 ? 6.34039  14.39590  -33.14567 1.000 20.76559 ? 119 TRP A CE3 1 
ATOM   846  C CZ2 . TRP A 1 120 ? 4.11376  13.22311  -34.44231 1.000 21.30359 ? 119 TRP A CZ2 1 
ATOM   847  C CZ3 . TRP A 1 120 ? 5.64022  13.34878  -32.57586 1.000 20.51473 ? 119 TRP A CZ3 1 
ATOM   848  C CH2 . TRP A 1 120 ? 4.53786  12.77773  -33.22096 1.000 24.13066 ? 119 TRP A CH2 1 
ATOM   849  N N   . PRO A 1 121 ? 10.84401 17.58708  -36.61449 1.000 19.65160 ? 120 PRO A N   1 
ATOM   850  C CA  . PRO A 1 121 ? 12.05924 18.36281  -36.31380 1.000 22.69903 ? 120 PRO A CA  1 
ATOM   851  C C   . PRO A 1 121 ? 11.81407 19.84601  -36.02476 1.000 25.36548 ? 120 PRO A C   1 
ATOM   852  O O   . PRO A 1 121 ? 12.62500 20.46163  -35.32541 1.000 30.16713 ? 120 PRO A O   1 
ATOM   853  C CB  . PRO A 1 121 ? 12.91924 18.16367  -37.57213 1.000 25.24486 ? 120 PRO A CB  1 
ATOM   854  C CG  . PRO A 1 121 ? 11.94306 17.83534  -38.66108 1.000 20.87998 ? 120 PRO A CG  1 
ATOM   855  C CD  . PRO A 1 121 ? 10.83896 17.05902  -37.99451 1.000 19.32550 ? 120 PRO A CD  1 
ATOM   856  N N   . HIS A 1 122 ? 10.72346 20.43036  -36.50753 1.000 25.97808 ? 121 HIS A N   1 
ATOM   857  C CA  . HIS A 1 122 ? 10.50276 21.86602  -36.39137 1.000 34.27679 ? 121 HIS A CA  1 
ATOM   858  C C   . HIS A 1 122 ? 9.58679  22.25643  -35.24021 1.000 38.03372 ? 121 HIS A C   1 
ATOM   859  O O   . HIS A 1 122 ? 9.36918  23.45453  -35.02736 1.000 36.50600 ? 121 HIS A O   1 
ATOM   860  C CB  . HIS A 1 122 ? 9.92232  22.40613  -37.70095 1.000 34.36310 ? 121 HIS A CB  1 
ATOM   861  C CG  . HIS A 1 122 ? 10.73757 22.04671  -38.89798 1.000 38.71250 ? 121 HIS A CG  1 
ATOM   862  N ND1 . HIS A 1 122 ? 12.10678 22.20522  -38.93811 1.000 42.98768 ? 121 HIS A ND1 1 
ATOM   863  C CD2 . HIS A 1 122 ? 10.38658 21.48387  -40.07672 1.000 36.65644 ? 121 HIS A CD2 1 
ATOM   864  C CE1 . HIS A 1 122 ? 12.56123 21.77985  -40.10407 1.000 34.51535 ? 121 HIS A CE1 1 
ATOM   865  N NE2 . HIS A 1 122 ? 11.53749 21.33845  -40.81371 1.000 46.04751 ? 121 HIS A NE2 1 
ATOM   866  N N   . ASP A 1 123 ? 9.04563  21.29340  -34.49536 1.000 36.05111 ? 122 ASP A N   1 
ATOM   867  C CA  . ASP A 1 123 ? 8.07597  21.56997  -33.43206 1.000 30.36239 ? 122 ASP A CA  1 
ATOM   868  C C   . ASP A 1 123 ? 8.70983  21.22463  -32.08846 1.000 29.77457 ? 122 ASP A C   1 
ATOM   869  O O   . ASP A 1 123 ? 8.59334  20.09665  -31.61181 1.000 28.72518 ? 122 ASP A O   1 
ATOM   870  C CB  . ASP A 1 123 ? 6.79094  20.77952  -33.64802 1.000 33.02677 ? 122 ASP A CB  1 
ATOM   871  C CG  . ASP A 1 123 ? 5.61157  21.36118  -32.88357 1.000 37.88717 ? 122 ASP A CG  1 
ATOM   872  O OD1 . ASP A 1 123 ? 5.81115  21.82985  -31.73663 1.000 37.02570 ? 122 ASP A OD1 1 
ATOM   873  O OD2 . ASP A 1 123 ? 4.48113  21.33234  -33.41615 1.000 43.90878 ? 122 ASP A OD2 1 
ATOM   874  N N   . LYS A 1 124 ? 9.36782  22.21067  -31.46855 1.000 34.24609 ? 123 LYS A N   1 
ATOM   875  C CA  . LYS A 1 124 ? 10.04107 21.96435  -30.19606 1.000 35.72154 ? 123 LYS A CA  1 
ATOM   876  C C   . LYS A 1 124 ? 9.05548  21.56833  -29.10615 1.000 36.37010 ? 123 LYS A C   1 
ATOM   877  O O   . LYS A 1 124 ? 9.38649  20.76143  -28.22782 1.000 32.02835 ? 123 LYS A O   1 
ATOM   878  C CB  . LYS A 1 124 ? 10.82575 23.20358  -29.75417 1.000 44.46861 ? 123 LYS A CB  1 
ATOM   879  C CG  . LYS A 1 124 ? 12.10835 23.46671  -30.54287 1.000 54.91637 ? 123 LYS A CG  1 
ATOM   880  C CD  . LYS A 1 124 ? 12.41338 24.96403  -30.61532 1.000 60.48697 ? 123 LYS A CD  1 
ATOM   881  C CE  . LYS A 1 124 ? 13.64669 25.25355  -31.46329 1.000 57.69756 ? 123 LYS A CE  1 
ATOM   882  N NZ  . LYS A 1 124 ? 13.60856 24.53329  -32.76674 1.000 59.91290 ? 123 LYS A NZ  1 
ATOM   883  N N   . ASP A 1 125 ? 7.84454  22.12363  -29.14479 1.000 38.28217 ? 124 ASP A N   1 
ATOM   884  C CA  . ASP A 1 125 ? 6.86640  21.82695  -28.10741 1.000 34.68057 ? 124 ASP A CA  1 
ATOM   885  C C   . ASP A 1 125 ? 6.42433  20.37024  -28.16101 1.000 32.09361 ? 124 ASP A C   1 
ATOM   886  O O   . ASP A 1 125 ? 6.17702  19.76117  -27.11240 1.000 30.62843 ? 124 ASP A O   1 
ATOM   887  C CB  . ASP A 1 125 ? 5.66657  22.75991  -28.24908 1.000 40.23636 ? 124 ASP A CB  1 
ATOM   888  C CG  . ASP A 1 125 ? 5.90322  24.10974  -27.60045 1.000 57.07489 ? 124 ASP A CG  1 
ATOM   889  O OD1 . ASP A 1 125 ? 7.08369  24.44593  -27.35042 1.000 58.31851 ? 124 ASP A OD1 1 
ATOM   890  O OD2 . ASP A 1 125 ? 4.91476  24.83443  -27.34214 1.000 67.23451 ? 124 ASP A OD2 1 
ATOM   891  N N   . ARG A 1 126 ? 6.33882  19.79041  -29.36288 1.000 27.98272 ? 125 ARG A N   1 
ATOM   892  C CA  . ARG A 1 126 ? 6.00506  18.37381  -29.50915 1.000 25.88624 ? 125 ARG A CA  1 
ATOM   893  C C   . ARG A 1 126 ? 7.12945  17.44169  -29.10732 1.000 26.66529 ? 125 ARG A C   1 
ATOM   894  O O   . ARG A 1 126 ? 6.90575  16.23219  -29.02279 1.000 29.49972 ? 125 ARG A O   1 
ATOM   895  C CB  . ARG A 1 126 ? 5.61714  18.01952  -30.95014 1.000 29.23441 ? 125 ARG A CB  1 
ATOM   896  C CG  . ARG A 1 126 ? 4.13350  18.01434  -31.22775 1.000 37.94627 ? 125 ARG A CG  1 
ATOM   897  C CD  . ARG A 1 126 ? 3.82529  17.64742  -32.67774 1.000 34.84400 ? 125 ARG A CD  1 
ATOM   898  N NE  . ARG A 1 126 ? 2.81729  18.51027  -33.27850 1.000 36.29000 ? 125 ARG A NE  1 
ATOM   899  C CZ  . ARG A 1 126 ? 2.62924  18.63598  -34.58429 1.000 41.36980 ? 125 ARG A CZ  1 
ATOM   900  N NH1 . ARG A 1 126 ? 3.37926  17.98053  -35.45738 1.000 36.23611 ? 125 ARG A NH1 1 
ATOM   901  N NH2 . ARG A 1 126 ? 1.65556  19.42901  -35.02690 1.000 47.76501 ? 125 ARG A NH2 1 
ATOM   902  N N   . GLN A 1 127 ? 8.33046  17.94799  -28.91101 1.000 25.31181 ? 126 GLN A N   1 
ATOM   903  C CA  . GLN A 1 127 ? 9.43963  17.07165  -28.60218 1.000 22.47298 ? 126 GLN A CA  1 
ATOM   904  C C   . GLN A 1 127 ? 9.57633  16.82314  -27.10913 1.000 23.42037 ? 126 GLN A C   1 
ATOM   905  O O   . GLN A 1 127 ? 10.34920 15.94293  -26.71285 1.000 25.67445 ? 126 GLN A O   1 
ATOM   906  C CB  . GLN A 1 127 ? 10.72510 17.67447  -29.16147 1.000 22.97239 ? 126 GLN A CB  1 
ATOM   907  C CG  . GLN A 1 127 ? 10.68478 17.80069  -30.67810 1.000 19.52538 ? 126 GLN A CG  1 
ATOM   908  C CD  . GLN A 1 127 ? 11.79089 18.65137  -31.21961 1.000 27.21068 ? 126 GLN A CD  1 
ATOM   909  O OE1 . GLN A 1 127 ? 12.66327 19.10259  -30.47901 1.000 25.87170 ? 126 GLN A OE1 1 
ATOM   910  N NE2 . GLN A 1 127 ? 11.78771 18.85543  -32.53183 1.000 22.95242 ? 126 GLN A NE2 1 
ATOM   911  N N   . SER A 1 128 ? 8.87463  17.59702  -26.28395 1.000 23.55879 ? 127 SER A N   1 
ATOM   912  C CA  . SER A 1 128 ? 8.86886  17.39782  -24.84247 1.000 24.38273 ? 127 SER A CA  1 
ATOM   913  C C   . SER A 1 128 ? 7.83687  16.35106  -24.47119 1.000 24.02075 ? 127 SER A C   1 
ATOM   914  O O   . SER A 1 128 ? 6.86760  16.10834  -25.19458 1.000 20.70363 ? 127 SER A O   1 
ATOM   915  C CB  . SER A 1 128 ? 8.55289  18.69640  -24.10477 1.000 25.42235 ? 127 SER A CB  1 
ATOM   916  O OG  . SER A 1 128 ? 7.22231  19.11697  -24.37907 1.000 26.21743 ? 127 SER A OG  1 
ATOM   917  N N   . LEU A 1 129 ? 8.04102  15.73979  -23.30852 1.000 21.31344 ? 128 LEU A N   1 
ATOM   918  C CA  . LEU A 1 129 ? 7.12406  14.68822  -22.89306 1.000 21.91054 ? 128 LEU A CA  1 
ATOM   919  C C   . LEU A 1 129 ? 5.71320  15.23048  -22.68199 1.000 24.05922 ? 128 LEU A C   1 
ATOM   920  O O   . LEU A 1 129 ? 4.73106  14.55094  -22.99783 1.000 21.18811 ? 128 LEU A O   1 
ATOM   921  C CB  . LEU A 1 129 ? 7.64756  14.01455  -21.62839 1.000 18.48866 ? 128 LEU A CB  1 
ATOM   922  C CG  . LEU A 1 129 ? 6.79979  12.82322  -21.21400 1.000 23.25740 ? 128 LEU A CG  1 
ATOM   923  C CD1 . LEU A 1 129 ? 6.99312  11.70719  -22.22106 1.000 26.67364 ? 128 LEU A CD1 1 
ATOM   924  C CD2 . LEU A 1 129 ? 7.21701  12.37896  -19.82646 1.000 28.26767 ? 128 LEU A CD2 1 
ATOM   925  N N   . ALA A 1 130 ? 5.58829  16.45068  -22.14901 1.000 20.38889 ? 129 ALA A N   1 
ATOM   926  C CA  . ALA A 1 130 ? 4.25905  17.03717  -21.99208 1.000 22.39069 ? 129 ALA A CA  1 
ATOM   927  C C   . ALA A 1 130 ? 3.60215  17.27672  -23.35121 1.000 20.22160 ? 129 ALA A C   1 
ATOM   928  O O   . ALA A 1 130 ? 2.40335  17.03301  -23.52121 1.000 21.47367 ? 129 ALA A O   1 
ATOM   929  C CB  . ALA A 1 130 ? 4.34444  18.33852  -21.19223 1.000 24.61913 ? 129 ALA A CB  1 
ATOM   930  N N   . GLY A 1 131 ? 4.37425  17.74063  -24.33374 1.000 22.13936 ? 130 GLY A N   1 
ATOM   931  C CA  . GLY A 1 131 ? 3.82235  17.91164  -25.67204 1.000 20.97562 ? 130 GLY A CA  1 
ATOM   932  C C   . GLY A 1 131 ? 3.37284  16.59573  -26.27879 1.000 22.20591 ? 130 GLY A C   1 
ATOM   933  O O   . GLY A 1 131 ? 2.29892  16.50917  -26.88204 1.000 21.47357 ? 130 GLY A O   1 
ATOM   934  N N   . LEU A 1 132 ? 4.17269  15.54488  -26.08947 1.000 18.40746 ? 131 LEU A N   1 
ATOM   935  C CA  . LEU A 1 132 ? 3.83240  14.22774  -26.60935 1.000 17.02016 ? 131 LEU A CA  1 
ATOM   936  C C   . LEU A 1 132 ? 2.64589  13.62655  -25.87260 1.000 20.03703 ? 131 LEU A C   1 
ATOM   937  O O   . LEU A 1 132 ? 1.76692  13.01457  -26.49172 1.000 19.37477 ? 131 LEU A O   1 
ATOM   938  C CB  . LEU A 1 132 ? 5.03648  13.30484  -26.49161 1.000 17.36712 ? 131 LEU A CB  1 
ATOM   939  C CG  . LEU A 1 132 ? 6.23026  13.58019  -27.40825 1.000 17.73469 ? 131 LEU A CG  1 
ATOM   940  C CD1 . LEU A 1 132 ? 7.43287  12.77684  -26.95925 1.000 18.57488 ? 131 LEU A CD1 1 
ATOM   941  C CD2 . LEU A 1 132 ? 5.88521  13.25413  -28.87782 1.000 18.24304 ? 131 LEU A CD2 1 
ATOM   942  N N   . ALA A 1 133 ? 2.61368  13.74762  -24.53953 1.000 16.64151 ? 132 ALA A N   1 
ATOM   943  C CA  . ALA A 1 133 ? 1.48472  13.17437  -23.81714 1.000 18.40086 ? 132 ALA A CA  1 
ATOM   944  C C   . ALA A 1 133 ? 0.18232  13.86268  -24.21033 1.000 21.16983 ? 132 ALA A C   1 
ATOM   945  O O   . ALA A 1 133 ? -0.87212 13.22055  -24.28528 1.000 20.73442 ? 132 ALA A O   1 
ATOM   946  C CB  . ALA A 1 133 ? 1.70874  13.26620  -22.30541 1.000 18.89300 ? 132 ALA A CB  1 
ATOM   947  N N   . HIS A 1 134 ? 0.24027  15.16876  -24.46977 1.000 17.89364 ? 133 HIS A N   1 
ATOM   948  C CA  . HIS A 1 134 ? -0.96073 15.90482  -24.84921 1.000 19.83699 ? 133 HIS A CA  1 
ATOM   949  C C   . HIS A 1 134 ? -1.42390 15.51590  -26.25092 1.000 24.99629 ? 133 HIS A C   1 
ATOM   950  O O   . HIS A 1 134 ? -2.59329 15.16744  -26.46332 1.000 21.67392 ? 133 HIS A O   1 
ATOM   951  C CB  . HIS A 1 134 ? -0.68370 17.40393  -24.76257 1.000 24.29297 ? 133 HIS A CB  1 
ATOM   952  C CG  . HIS A 1 134 ? -1.89754 18.25151  -24.97080 1.000 30.30488 ? 133 HIS A CG  1 
ATOM   953  N ND1 . HIS A 1 134 ? -3.17509 17.78823  -24.73984 1.000 34.82502 ? 133 HIS A ND1 1 
ATOM   954  C CD2 . HIS A 1 134 ? -2.02888 19.53747  -25.37225 1.000 39.71527 ? 133 HIS A CD2 1 
ATOM   955  C CE1 . HIS A 1 134 ? -4.04237 18.74851  -25.00239 1.000 33.90720 ? 133 HIS A CE1 1 
ATOM   956  N NE2 . HIS A 1 134 ? -3.37282 19.82196  -25.38298 1.000 37.14532 ? 133 HIS A NE2 1 
ATOM   957  N N   . LEU A 1 135 ? -0.50595 15.56276  -27.21423 1.000 21.62197 ? 134 LEU A N   1 
ATOM   958  C CA  . LEU A 1 135 ? -0.82978 15.23550  -28.60277 1.000 18.34711 ? 134 LEU A CA  1 
ATOM   959  C C   . LEU A 1 135 ? -1.32936 13.80258  -28.74094 1.000 20.48672 ? 134 LEU A C   1 
ATOM   960  O O   . LEU A 1 135 ? -2.35002 13.53838  -29.39153 1.000 20.28230 ? 134 LEU A O   1 
ATOM   961  C CB  . LEU A 1 135 ? 0.42041  15.43994  -29.45458 1.000 22.50634 ? 134 LEU A CB  1 
ATOM   962  C CG  . LEU A 1 135 ? 0.35139  14.89281  -30.87805 1.000 21.51161 ? 134 LEU A CG  1 
ATOM   963  C CD1 . LEU A 1 135 ? -0.66925 15.66794  -31.69375 1.000 24.11264 ? 134 LEU A CD1 1 
ATOM   964  C CD2 . LEU A 1 135 ? 1.73739  14.91770  -31.54061 1.000 24.52583 ? 134 LEU A CD2 1 
ATOM   965  N N   . LEU A 1 136 ? -0.59974 12.85474  -28.16355 1.000 19.36930 ? 135 LEU A N   1 
ATOM   966  C CA  . LEU A 1 136 ? -0.87615 11.45510  -28.44463 1.000 21.48478 ? 135 LEU A CA  1 
ATOM   967  C C   . LEU A 1 136 ? -1.90906 10.86865  -27.49879 1.000 23.49000 ? 135 LEU A C   1 
ATOM   968  O O   . LEU A 1 136 ? -2.78955 10.12482  -27.93735 1.000 24.38582 ? 135 LEU A O   1 
ATOM   969  C CB  . LEU A 1 136 ? 0.41231  10.63868  -28.38026 1.000 19.76054 ? 135 LEU A CB  1 
ATOM   970  C CG  . LEU A 1 136 ? 1.54050  11.03498  -29.33664 1.000 20.86078 ? 135 LEU A CG  1 
ATOM   971  C CD1 . LEU A 1 136 ? 2.78853  10.22573  -28.99998 1.000 23.07014 ? 135 LEU A CD1 1 
ATOM   972  C CD2 . LEU A 1 136 ? 1.10337  10.76347  -30.77368 1.000 24.21486 ? 135 LEU A CD2 1 
ATOM   973  N N   . LEU A 1 137 ? -1.83825 11.21284  -26.21461 1.000 19.09158 ? 136 LEU A N   1 
ATOM   974  C CA  . LEU A 1 137 ? -2.67006 10.58137  -25.20802 1.000 18.45299 ? 136 LEU A CA  1 
ATOM   975  C C   . LEU A 1 137 ? -3.81556 11.45322  -24.71604 1.000 21.26191 ? 136 LEU A C   1 
ATOM   976  O O   . LEU A 1 137 ? -4.66493 10.95584  -23.97005 1.000 23.99392 ? 136 LEU A O   1 
ATOM   977  C CB  . LEU A 1 137 ? -1.81799 10.18374  -23.99421 1.000 24.24081 ? 136 LEU A CB  1 
ATOM   978  C CG  . LEU A 1 137 ? -0.64962 9.24559   -24.25646 1.000 29.33138 ? 136 LEU A CG  1 
ATOM   979  C CD1 . LEU A 1 137 ? -0.09384 8.75826   -22.94222 1.000 26.72016 ? 136 LEU A CD1 1 
ATOM   980  C CD2 . LEU A 1 137 ? -1.11412 8.09104   -25.08996 1.000 30.71529 ? 136 LEU A CD2 1 
ATOM   981  N N   . GLY A 1 138 ? -3.85418 12.72420  -25.10234 1.000 20.01241 ? 137 GLY A N   1 
ATOM   982  C CA  . GLY A 1 138 ? -4.79949 13.66034  -24.53609 1.000 22.31436 ? 137 GLY A CA  1 
ATOM   983  C C   . GLY A 1 138 ? -4.57207 13.93229  -23.07015 1.000 23.74134 ? 137 GLY A C   1 
ATOM   984  O O   . GLY A 1 138 ? -5.49174 14.38228  -22.38265 1.000 27.90141 ? 137 GLY A O   1 
ATOM   985  N N   . VAL A 1 139 ? -3.36608 13.67342  -22.57010 1.000 23.62041 ? 138 VAL A N   1 
ATOM   986  C CA  . VAL A 1 139 ? -3.03962 13.82581  -21.15470 1.000 22.26463 ? 138 VAL A CA  1 
ATOM   987  C C   . VAL A 1 139 ? -2.26677 15.12149  -20.96464 1.000 24.63354 ? 138 VAL A C   1 
ATOM   988  O O   . VAL A 1 139 ? -1.31478 15.39952  -21.70021 1.000 25.67334 ? 138 VAL A O   1 
ATOM   989  C CB  . VAL A 1 139 ? -2.23004 12.62106  -20.63708 1.000 22.90007 ? 138 VAL A CB  1 
ATOM   990  C CG1 . VAL A 1 139 ? -1.75773 12.86784  -19.21634 1.000 22.99793 ? 138 VAL A CG1 1 
ATOM   991  C CG2 . VAL A 1 139 ? -3.06463 11.36311  -20.67025 1.000 23.90543 ? 138 VAL A CG2 1 
ATOM   992  N N   . VAL A 1 140 ? -2.65123 15.90242  -19.95767 1.000 25.97186 ? 139 VAL A N   1 
ATOM   993  C CA  . VAL A 1 140 ? -1.99238 17.16642  -19.65215 1.000 24.51549 ? 139 VAL A CA  1 
ATOM   994  C C   . VAL A 1 140 ? -1.15054 16.95444  -18.39724 1.000 29.29392 ? 139 VAL A C   1 
ATOM   995  O O   . VAL A 1 140 ? -1.68983 16.76879  -17.29929 1.000 27.83889 ? 139 VAL A O   1 
ATOM   996  C CB  . VAL A 1 140 ? -3.00521 18.30523  -19.46263 1.000 32.97729 ? 139 VAL A CB  1 
ATOM   997  C CG1 . VAL A 1 140 ? -2.30850 19.57474  -18.96437 1.000 32.49610 ? 139 VAL A CG1 1 
ATOM   998  C CG2 . VAL A 1 140 ? -3.74998 18.56613  -20.76314 1.000 34.09886 ? 139 VAL A CG2 1 
ATOM   999  N N   . LEU A 1 141 ? 0.17165  16.97563  -18.55046 1.000 24.61496 ? 140 LEU A N   1 
ATOM   1000 C CA  . LEU A 1 141 ? 1.05717  16.80304  -17.40175 1.000 30.91422 ? 140 LEU A CA  1 
ATOM   1001 C C   . LEU A 1 141 ? 1.08789  18.08811  -16.58633 1.000 33.11580 ? 140 LEU A C   1 
ATOM   1002 O O   . LEU A 1 141 ? 1.28867  19.17327  -17.13798 1.000 37.65030 ? 140 LEU A O   1 
ATOM   1003 C CB  . LEU A 1 141 ? 2.46860  16.43951  -17.85804 1.000 29.73171 ? 140 LEU A CB  1 
ATOM   1004 C CG  . LEU A 1 141 ? 2.61311  15.20418  -18.74734 1.000 27.38897 ? 140 LEU A CG  1 
ATOM   1005 C CD1 . LEU A 1 141 ? 4.08826  14.89451  -18.97149 1.000 29.92110 ? 140 LEU A CD1 1 
ATOM   1006 C CD2 . LEU A 1 141 ? 1.89907  14.00981  -18.13565 1.000 30.99595 ? 140 LEU A CD2 1 
ATOM   1007 N N   . ASP A 1 142 ? 0.87881  17.96622  -15.27745 1.000 47.20613 ? 141 ASP A N   1 
ATOM   1008 C CA  . ASP A 1 142 ? 0.94212  19.12312  -14.38590 1.000 49.53845 ? 141 ASP A CA  1 
ATOM   1009 C C   . ASP A 1 142 ? 2.27669  19.84750  -14.52823 1.000 52.44904 ? 141 ASP A C   1 
ATOM   1010 O O   . ASP A 1 142 ? 3.33492  19.26408  -14.30814 1.000 45.30738 ? 141 ASP A O   1 
ATOM   1011 C CB  . ASP A 1 142 ? 0.72936  18.70307  -12.92922 1.000 49.91646 ? 141 ASP A CB  1 
ATOM   1012 C CG  . ASP A 1 142 ? 0.21696  19.84339  -12.05917 1.000 64.88823 ? 141 ASP A CG  1 
ATOM   1013 O OD1 . ASP A 1 142 ? 0.76990  20.96112  -12.15843 1.000 65.52244 ? 141 ASP A OD1 1 
ATOM   1014 O OD2 . ASP A 1 142 ? -0.72114 19.61777  -11.26005 1.000 58.82519 ? 141 ASP A OD2 1 
ATOM   1015 N N   . SER A 1 148 ? 10.59550 20.25996  -5.62459  1.000 65.61655 ? 147 SER A N   1 
ATOM   1016 C CA  . SER A 1 148 ? 11.57922 21.25586  -6.04173  1.000 68.99862 ? 147 SER A CA  1 
ATOM   1017 C C   . SER A 1 148 ? 12.91293 21.07028  -5.31308  1.000 68.93197 ? 147 SER A C   1 
ATOM   1018 O O   . SER A 1 148 ? 13.97846 21.21136  -5.91371  1.000 70.76047 ? 147 SER A O   1 
ATOM   1019 C CB  . SER A 1 148 ? 11.04049 22.66953  -5.80967  1.000 69.51494 ? 147 SER A CB  1 
ATOM   1020 O OG  . SER A 1 148 ? 10.81974 22.91204  -4.43063  1.000 77.23409 ? 147 SER A OG  1 
ATOM   1021 N N   . ASP A 1 149 ? 12.85082 20.76182  -4.01591  1.000 70.13830 ? 148 ASP A N   1 
ATOM   1022 C CA  . ASP A 1 149 ? 14.04244 20.43478  -3.23279  1.000 67.43730 ? 148 ASP A CA  1 
ATOM   1023 C C   . ASP A 1 149 ? 14.14634 18.91539  -3.13496  1.000 67.96141 ? 148 ASP A C   1 
ATOM   1024 O O   . ASP A 1 149 ? 13.75385 18.29307  -2.14547  1.000 67.64342 ? 148 ASP A O   1 
ATOM   1025 C CB  . ASP A 1 149 ? 13.99305 21.08528  -1.85448  1.000 69.69195 ? 148 ASP A CB  1 
ATOM   1026 C CG  . ASP A 1 149 ? 15.31016 20.95379  -1.10428  1.000 74.94326 ? 148 ASP A CG  1 
ATOM   1027 O OD1 . ASP A 1 149 ? 16.28266 20.43057  -1.69379  1.000 67.50550 ? 148 ASP A OD1 1 
ATOM   1028 O OD2 . ASP A 1 149 ? 15.37074 21.35884  0.07750   1.000 75.98544 ? 148 ASP A OD2 1 
ATOM   1029 N N   . TRP A 1 150 ? 14.70796 18.31711  -4.18678  1.000 60.66011 ? 149 TRP A N   1 
ATOM   1030 C CA  . TRP A 1 150 ? 14.83972 16.86768  -4.27993  1.000 58.77019 ? 149 TRP A CA  1 
ATOM   1031 C C   . TRP A 1 150 ? 15.91108 16.29716  -3.36194  1.000 60.34626 ? 149 TRP A C   1 
ATOM   1032 O O   . TRP A 1 150 ? 16.07984 15.07156  -3.33362  1.000 53.01113 ? 149 TRP A O   1 
ATOM   1033 C CB  . TRP A 1 150 ? 15.12158 16.48089  -5.72710  1.000 49.46664 ? 149 TRP A CB  1 
ATOM   1034 C CG  . TRP A 1 150 ? 13.96687 16.77311  -6.61701  1.000 51.49713 ? 149 TRP A CG  1 
ATOM   1035 C CD1 . TRP A 1 150 ? 13.87752 17.76506  -7.55587  1.000 54.84249 ? 149 TRP A CD1 1 
ATOM   1036 C CD2 . TRP A 1 150 ? 12.72883 16.05791  -6.66858  1.000 52.12427 ? 149 TRP A CD2 1 
ATOM   1037 N NE1 . TRP A 1 150 ? 12.65415 17.71299  -8.18235  1.000 57.18320 ? 149 TRP A NE1 1 
ATOM   1038 C CE2 . TRP A 1 150 ? 11.93027 16.67465  -7.65524  1.000 54.31473 ? 149 TRP A CE2 1 
ATOM   1039 C CE3 . TRP A 1 150 ? 12.21911 14.95244  -5.98010  1.000 44.57501 ? 149 TRP A CE3 1 
ATOM   1040 C CZ2 . TRP A 1 150 ? 10.64884 16.22311  -7.96816  1.000 51.61504 ? 149 TRP A CZ2 1 
ATOM   1041 C CZ3 . TRP A 1 150 ? 10.94994 14.51011  -6.28727  1.000 42.06746 ? 149 TRP A CZ3 1 
ATOM   1042 C CH2 . TRP A 1 150 ? 10.17613 15.14414  -7.27299  1.000 49.17185 ? 149 TRP A CH2 1 
ATOM   1043 N N   . SER A 1 151 ? 16.61991 17.13968  -2.61138  1.000 60.24427 ? 150 SER A N   1 
ATOM   1044 C CA  . SER A 1 151 ? 17.62641 16.69664  -1.65750  1.000 64.34326 ? 150 SER A CA  1 
ATOM   1045 C C   . SER A 1 151 ? 17.13855 16.78778  -0.21465  1.000 65.60066 ? 150 SER A C   1 
ATOM   1046 O O   . SER A 1 151 ? 17.93152 16.58684  0.71359   1.000 57.20380 ? 150 SER A O   1 
ATOM   1047 C CB  . SER A 1 151 ? 18.91209 17.51015  -1.83640  1.000 65.31273 ? 150 SER A CB  1 
ATOM   1048 O OG  . SER A 1 151 ? 19.81116 16.86542  -2.72711  1.000 67.17062 ? 150 SER A OG  1 
ATOM   1049 N N   . GLN A 1 152 ? 15.85161 17.08954  -0.01212  1.000 66.08521 ? 151 GLN A N   1 
ATOM   1050 C CA  . GLN A 1 152 ? 15.21125 17.17555  1.29650   1.000 68.22163 ? 151 GLN A CA  1 
ATOM   1051 C C   . GLN A 1 152 ? 15.47556 15.91301  2.10673   1.000 71.21542 ? 151 GLN A C   1 
ATOM   1052 O O   . GLN A 1 152 ? 15.63321 14.83137  1.52760   1.000 66.52503 ? 151 GLN A O   1 
ATOM   1053 C CB  . GLN A 1 152 ? 13.70046 17.37556  1.14461   1.000 66.11763 ? 151 GLN A CB  1 
ATOM   1054 C CG  . GLN A 1 152 ? 13.23421 18.82064  1.14213   1.000 69.93680 ? 151 GLN A CG  1 
ATOM   1055 C CD  . GLN A 1 152 ? 11.76349 18.94707  0.78345   1.000 72.41102 ? 151 GLN A CD  1 
ATOM   1056 O OE1 . GLN A 1 152 ? 11.10651 17.95839  0.45443   1.000 70.33982 ? 151 GLN A OE1 1 
ATOM   1057 N NE2 . GLN A 1 152 ? 11.23939 20.16590  0.84752   1.000 72.71940 ? 151 GLN A NE2 1 
ATOM   1058 N N   . PRO A 1 153 ? 15.52703 15.99972  3.43886   1.000 69.66844 ? 152 PRO A N   1 
ATOM   1059 C CA  . PRO A 1 153 ? 15.65043 14.76843  4.23555   1.000 67.72876 ? 152 PRO A CA  1 
ATOM   1060 C C   . PRO A 1 153 ? 14.51818 13.78613  3.99051   1.000 66.42708 ? 152 PRO A C   1 
ATOM   1061 O O   . PRO A 1 153 ? 14.71726 12.57447  4.14726   1.000 70.58355 ? 152 PRO A O   1 
ATOM   1062 C CB  . PRO A 1 153 ? 15.65466 15.28452  5.68291   1.000 70.17304 ? 152 PRO A CB  1 
ATOM   1063 C CG  . PRO A 1 153 ? 15.06826 16.66883  5.60416   1.000 72.44441 ? 152 PRO A CG  1 
ATOM   1064 C CD  . PRO A 1 153 ? 15.51999 17.20422  4.28484   1.000 67.35631 ? 152 PRO A CD  1 
ATOM   1065 N N   . GLU A 1 154 ? 13.33969 14.26832  3.59515   1.000 60.59442 ? 153 GLU A N   1 
ATOM   1066 C CA  . GLU A 1 154 ? 12.20042 13.40462  3.31308   1.000 61.02287 ? 153 GLU A CA  1 
ATOM   1067 C C   . GLU A 1 154 ? 11.44413 13.89876  2.09232   1.000 61.56378 ? 153 GLU A C   1 
ATOM   1068 O O   . GLU A 1 154 ? 11.13632 15.08999  1.98523   1.000 61.50039 ? 153 GLU A O   1 
ATOM   1069 C CB  . GLU A 1 154 ? 11.25025 13.32769  4.51280   1.000 63.74771 ? 153 GLU A CB  1 
ATOM   1070 C CG  . GLU A 1 154 ? 10.46049 12.02817  4.59940   1.000 63.11708 ? 153 GLU A CG  1 
ATOM   1071 C CD  . GLU A 1 154 ? 11.33105 10.78529  4.69282   1.000 60.63096 ? 153 GLU A CD  1 
ATOM   1072 O OE1 . GLU A 1 154 ? 12.55792 10.89960  4.93003   1.000 60.71853 ? 153 GLU A OE1 1 
ATOM   1073 O OE2 . GLU A 1 154 ? 10.77497 9.68128   4.51147   1.000 57.60312 ? 153 GLU A OE2 1 
ATOM   1074 N N   . LEU A 1 155 ? 11.14189 12.97844  1.18016   1.000 59.00579 ? 154 LEU A N   1 
ATOM   1075 C CA  . LEU A 1 155 ? 10.29790 13.29543  0.04004   1.000 55.03857 ? 154 LEU A CA  1 
ATOM   1076 C C   . LEU A 1 155 ? 8.83302  13.27370  0.45907   1.000 52.77578 ? 154 LEU A C   1 
ATOM   1077 O O   . LEU A 1 155 ? 8.36161  12.31162  1.07600   1.000 49.94872 ? 154 LEU A O   1 
ATOM   1078 C CB  . LEU A 1 155 ? 10.54601 12.31512  -1.10644  1.000 46.83570 ? 154 LEU A CB  1 
ATOM   1079 C CG  . LEU A 1 155 ? 11.92101 12.37461  -1.77253  1.000 53.17395 ? 154 LEU A CG  1 
ATOM   1080 C CD1 . LEU A 1 155 ? 11.86810 11.71768  -3.13803  1.000 44.46753 ? 154 LEU A CD1 1 
ATOM   1081 C CD2 . LEU A 1 155 ? 12.39312 13.81585  -1.90701  1.000 54.50356 ? 154 LEU A CD2 1 
ATOM   1082 N N   . THR A 1 156 ? 8.12099  14.34441  0.13136   1.000 52.38223 ? 155 THR A N   1 
ATOM   1083 C CA  . THR A 1 156 ? 6.70647  14.44724  0.43869   1.000 53.16408 ? 155 THR A CA  1 
ATOM   1084 C C   . THR A 1 156 ? 5.88571  13.61535  -0.54423  1.000 54.58276 ? 155 THR A C   1 
ATOM   1085 O O   . THR A 1 156 ? 6.36072  13.22512  -1.61532  1.000 47.47951 ? 155 THR A O   1 
ATOM   1086 C CB  . THR A 1 156 ? 6.26454  15.90964  0.39291   1.000 55.12953 ? 155 THR A CB  1 
ATOM   1087 O OG1 . THR A 1 156 ? 6.46273  16.42653  -0.93032  1.000 48.42670 ? 155 THR A OG1 1 
ATOM   1088 C CG2 . THR A 1 156 ? 7.08970  16.73236  1.37295   1.000 50.07909 ? 155 THR A CG2 1 
ATOM   1089 N N   . LYS A 1 157 ? 4.63233  13.34315  -0.16333  1.000 51.25988 ? 156 LYS A N   1 
ATOM   1090 C CA  . LYS A 1 157 ? 3.73523  12.61780  -1.05704  1.000 50.49188 ? 156 LYS A CA  1 
ATOM   1091 C C   . LYS A 1 157 ? 3.52861  13.36636  -2.36764  1.000 51.47740 ? 156 LYS A C   1 
ATOM   1092 O O   . LYS A 1 157 ? 3.33715  12.74291  -3.41896  1.000 48.09269 ? 156 LYS A O   1 
ATOM   1093 C CB  . LYS A 1 157 ? 2.39007  12.36999  -0.37373  1.000 56.43974 ? 156 LYS A CB  1 
ATOM   1094 C CG  . LYS A 1 157 ? 1.52702  11.33204  -1.07943  1.000 61.02271 ? 156 LYS A CG  1 
ATOM   1095 C CD  . LYS A 1 157 ? 0.15091  11.20636  -0.44517  1.000 67.95385 ? 156 LYS A CD  1 
ATOM   1096 C CE  . LYS A 1 157 ? -0.85608 10.62561  -1.43209  1.000 71.04202 ? 156 LYS A CE  1 
ATOM   1097 N NZ  . LYS A 1 157 ? -2.21166 10.45676  -0.83338  1.000 69.31993 ? 156 LYS A NZ  1 
ATOM   1098 N N   . THR A 1 158 ? 3.56430  14.69854  -2.32807  1.000 50.94084 ? 157 THR A N   1 
ATOM   1099 C CA  . THR A 1 158 ? 3.42795  15.47118  -3.55723  1.000 52.38482 ? 157 THR A CA  1 
ATOM   1100 C C   . THR A 1 158 ? 4.67380  15.33261  -4.42390  1.000 47.79590 ? 157 THR A C   1 
ATOM   1101 O O   . THR A 1 158 ? 4.57759  15.18812  -5.64799  1.000 41.78621 ? 157 THR A O   1 
ATOM   1102 C CB  . THR A 1 158 ? 3.15997  16.94075  -3.22681  1.000 53.28206 ? 157 THR A CB  1 
ATOM   1103 O OG1 . THR A 1 158 ? 2.35906  17.03193  -2.03662  1.000 55.13476 ? 157 THR A OG1 1 
ATOM   1104 C CG2 . THR A 1 158 ? 2.43224  17.61021  -4.37160  1.000 52.13896 ? 157 THR A CG2 1 
ATOM   1105 N N   . GLN A 1 159 ? 5.85087  15.37151  -3.79930  1.000 46.32319 ? 158 GLN A N   1 
ATOM   1106 C CA  . GLN A 1 159 ? 7.09209  15.15451  -4.53032  1.000 44.12894 ? 158 GLN A CA  1 
ATOM   1107 C C   . GLN A 1 159 ? 7.13069  13.75305  -5.12868  1.000 39.38556 ? 158 GLN A C   1 
ATOM   1108 O O   . GLN A 1 159 ? 7.51466  13.57345  -6.29089  1.000 38.42222 ? 158 GLN A O   1 
ATOM   1109 C CB  . GLN A 1 159 ? 8.27246  15.37974  -3.58684  1.000 50.70612 ? 158 GLN A CB  1 
ATOM   1110 C CG  . GLN A 1 159 ? 8.95221  16.73181  -3.74150  1.000 54.86302 ? 158 GLN A CG  1 
ATOM   1111 C CD  . GLN A 1 159 ? 10.12808 16.89785  -2.80085  1.000 57.11547 ? 158 GLN A CD  1 
ATOM   1112 O OE1 . GLN A 1 159 ? 10.06838 16.48851  -1.63848  1.000 52.65753 ? 158 GLN A OE1 1 
ATOM   1113 N NE2 . GLN A 1 159 ? 11.20674 17.49692  -3.29752  1.000 57.51184 ? 158 GLN A NE2 1 
ATOM   1114 N N   . VAL A 1 160 ? 6.69824  12.75356  -4.35600  1.000 34.72585 ? 159 VAL A N   1 
ATOM   1115 C CA  . VAL A 1 160 ? 6.78504  11.36358  -4.79195  1.000 38.40625 ? 159 VAL A CA  1 
ATOM   1116 C C   . VAL A 1 160 ? 5.84859  11.11446  -5.96773  1.000 34.81479 ? 159 VAL A C   1 
ATOM   1117 O O   . VAL A 1 160 ? 6.22434  10.46563  -6.95360  1.000 31.03916 ? 159 VAL A O   1 
ATOM   1118 C CB  . VAL A 1 160 ? 6.47476  10.42351  -3.61200  1.000 34.53539 ? 159 VAL A CB  1 
ATOM   1119 C CG1 . VAL A 1 160 ? 5.89727  9.10522   -4.10325  1.000 34.34478 ? 159 VAL A CG1 1 
ATOM   1120 C CG2 . VAL A 1 160 ? 7.70940  10.21638  -2.75641  1.000 39.70545 ? 159 VAL A CG2 1 
ATOM   1121 N N   . HIS A 1 161 ? 4.61869  11.63178  -5.89092  1.000 37.93471 ? 160 HIS A N   1 
ATOM   1122 C CA  . HIS A 1 161 ? 3.68245  11.42283  -6.98834  1.000 38.74153 ? 160 HIS A CA  1 
ATOM   1123 C C   . HIS A 1 161 ? 4.15215  12.14543  -8.24437  1.000 33.15085 ? 160 HIS A C   1 
ATOM   1124 O O   . HIS A 1 161 ? 4.06349  11.59520  -9.34744  1.000 35.48104 ? 160 HIS A O   1 
ATOM   1125 C CB  . HIS A 1 161 ? 2.27225  11.87649  -6.59821  1.000 43.43209 ? 160 HIS A CB  1 
ATOM   1126 C CG  . HIS A 1 161 ? 1.31564  11.91136  -7.75245  1.000 43.80524 ? 160 HIS A CG  1 
ATOM   1127 N ND1 . HIS A 1 161 ? 1.14700  13.02087  -8.55382  1.000 49.81023 ? 160 HIS A ND1 1 
ATOM   1128 C CD2 . HIS A 1 161 ? 0.49251  10.95999  -8.25339  1.000 48.28130 ? 160 HIS A CD2 1 
ATOM   1129 C CE1 . HIS A 1 161 ? 0.25513  12.75438  -9.49117  1.000 47.96648 ? 160 HIS A CE1 1 
ATOM   1130 N NE2 . HIS A 1 161 ? -0.15620 11.50935  -9.33228  1.000 53.32121 ? 160 HIS A NE2 1 
ATOM   1131 N N   . TYR A 1 162 ? 4.66574  13.37208  -8.10560  1.000 38.68073 ? 161 TYR A N   1 
ATOM   1132 C CA  . TYR A 1 162 ? 5.18649  14.05954  -9.28311  1.000 39.16180 ? 161 TYR A CA  1 
ATOM   1133 C C   . TYR A 1 162 ? 6.37173  13.31253  -9.87115  1.000 39.81731 ? 161 TYR A C   1 
ATOM   1134 O O   . TYR A 1 162 ? 6.45553  13.12552  -11.08978 1.000 37.45181 ? 161 TYR A O   1 
ATOM   1135 C CB  . TYR A 1 162 ? 5.61910  15.49296  -8.98149  1.000 41.11718 ? 161 TYR A CB  1 
ATOM   1136 C CG  . TYR A 1 162 ? 6.44522  16.00822  -10.15376 1.000 52.89683 ? 161 TYR A CG  1 
ATOM   1137 C CD1 . TYR A 1 162 ? 5.87465  16.13723  -11.42051 1.000 52.54086 ? 161 TYR A CD1 1 
ATOM   1138 C CD2 . TYR A 1 162 ? 7.80717  16.27161  -10.02309 1.000 54.16730 ? 161 TYR A CD2 1 
ATOM   1139 C CE1 . TYR A 1 162 ? 6.62060  16.56431  -12.50794 1.000 48.63999 ? 161 TYR A CE1 1 
ATOM   1140 C CE2 . TYR A 1 162 ? 8.56353  16.70046  -11.11067 1.000 50.49762 ? 161 TYR A CE2 1 
ATOM   1141 C CZ  . TYR A 1 162 ? 7.96330  16.84511  -12.34787 1.000 54.68307 ? 161 TYR A CZ  1 
ATOM   1142 O OH  . TYR A 1 162 ? 8.70298  17.27037  -13.43226 1.000 56.70559 ? 161 TYR A OH  1 
ATOM   1143 N N   . ALA A 1 163 ? 7.32762  12.91605  -9.02287  1.000 30.56421 ? 162 ALA A N   1 
ATOM   1144 C CA  . ALA A 1 163 ? 8.53538  12.28582  -9.53794  1.000 35.59983 ? 162 ALA A CA  1 
ATOM   1145 C C   . ALA A 1 163 ? 8.23178  11.05278  -10.36893 1.000 25.70361 ? 162 ALA A C   1 
ATOM   1146 O O   . ALA A 1 163 ? 9.04043  10.69044  -11.23141 1.000 31.80217 ? 162 ALA A O   1 
ATOM   1147 C CB  . ALA A 1 163 ? 9.47835  11.91733  -8.39072  1.000 32.72926 ? 162 ALA A CB  1 
ATOM   1148 N N   . ALA A 1 164 ? 7.07753  10.41001  -10.15241 1.000 26.62370 ? 163 ALA A N   1 
ATOM   1149 C CA  . ALA A 1 164 ? 6.74330  9.18666   -10.86683 1.000 21.76084 ? 163 ALA A CA  1 
ATOM   1150 C C   . ALA A 1 164 ? 5.95021  9.41351   -12.14979 1.000 25.26838 ? 163 ALA A C   1 
ATOM   1151 O O   . ALA A 1 164 ? 5.82929  8.47802   -12.94536 1.000 24.91545 ? 163 ALA A O   1 
ATOM   1152 C CB  . ALA A 1 164 ? 5.94824  8.23718   -9.96752  1.000 26.96524 ? 163 ALA A CB  1 
ATOM   1153 N N   . VAL A 1 165 ? 5.39589  10.60649  -12.38027 1.000 25.78218 ? 164 VAL A N   1 
ATOM   1154 C CA  . VAL A 1 165 ? 4.42774  10.72854  -13.46957 1.000 23.75657 ? 164 VAL A CA  1 
ATOM   1155 C C   . VAL A 1 165 ? 5.09799  10.48994  -14.81770 1.000 24.65432 ? 164 VAL A C   1 
ATOM   1156 O O   . VAL A 1 165 ? 4.55990  9.77327   -15.67426 1.000 22.80924 ? 164 VAL A O   1 
ATOM   1157 C CB  . VAL A 1 165 ? 3.69505  12.08543  -13.42170 1.000 34.05824 ? 164 VAL A CB  1 
ATOM   1158 C CG1 . VAL A 1 165 ? 4.65954  13.23962  -13.45463 1.000 35.89316 ? 164 VAL A CG1 1 
ATOM   1159 C CG2 . VAL A 1 165 ? 2.72994  12.20701  -14.60657 1.000 38.93724 ? 164 VAL A CG2 1 
ATOM   1160 N N   . ASP A 1 166 ? 6.29609  11.04543  -15.01918 1.000 24.03272 ? 165 ASP A N   1 
ATOM   1161 C CA  . ASP A 1 166 ? 6.89574  11.00103  -16.34659 1.000 25.24886 ? 165 ASP A CA  1 
ATOM   1162 C C   . ASP A 1 166 ? 7.26198  9.57643   -16.74747 1.000 22.33437 ? 165 ASP A C   1 
ATOM   1163 O O   . ASP A 1 166 ? 7.02039  9.17025   -17.88901 1.000 22.38758 ? 165 ASP A O   1 
ATOM   1164 C CB  . ASP A 1 166 ? 8.11820  11.91964  -16.39436 1.000 28.76099 ? 165 ASP A CB  1 
ATOM   1165 C CG  . ASP A 1 166 ? 7.74232  13.38493  -16.61359 1.000 33.69143 ? 165 ASP A CG  1 
ATOM   1166 O OD1 . ASP A 1 166 ? 6.53652  13.72977  -16.51879 1.000 31.44680 ? 165 ASP A OD1 1 
ATOM   1167 O OD2 . ASP A 1 166 ? 8.65841  14.20200  -16.84330 1.000 36.73695 ? 165 ASP A OD2 1 
ATOM   1168 N N   . VAL A 1 167 ? 7.83551  8.79178   -15.83104 1.000 18.84770 ? 166 VAL A N   1 
ATOM   1169 C CA  . VAL A 1 167 ? 8.20893  7.43485   -16.21130 1.000 16.00117 ? 166 VAL A CA  1 
ATOM   1170 C C   . VAL A 1 167 ? 6.97629  6.55610   -16.40788 1.000 19.89915 ? 166 VAL A C   1 
ATOM   1171 O O   . VAL A 1 167 ? 7.02288  5.59601   -17.17956 1.000 19.67162 ? 166 VAL A O   1 
ATOM   1172 C CB  . VAL A 1 167 ? 9.19162  6.79496   -15.20368 1.000 17.06885 ? 166 VAL A CB  1 
ATOM   1173 C CG1 . VAL A 1 167 ? 10.55969 7.47740   -15.27719 1.000 20.70554 ? 166 VAL A CG1 1 
ATOM   1174 C CG2 . VAL A 1 167 ? 8.63892  6.83402   -13.77451 1.000 18.43773 ? 166 VAL A CG2 1 
ATOM   1175 N N   . GLU A 1 168 ? 5.85987  6.83743   -15.72504 1.000 20.03246 ? 167 GLU A N   1 
ATOM   1176 C CA  . GLU A 1 168 ? 4.70636  5.96560   -15.93856 1.000 20.54034 ? 167 GLU A CA  1 
ATOM   1177 C C   . GLU A 1 168 ? 3.92572  6.28317   -17.20177 1.000 19.69580 ? 167 GLU A C   1 
ATOM   1178 O O   . GLU A 1 168 ? 3.25937  5.38555   -17.72471 1.000 22.17175 ? 167 GLU A O   1 
ATOM   1179 C CB  . GLU A 1 168 ? 3.76656  5.97969   -14.72922 1.000 24.15057 ? 167 GLU A CB  1 
ATOM   1180 C CG  . GLU A 1 168 ? 4.53656  5.86729   -13.44620 1.000 26.39796 ? 167 GLU A CG  1 
ATOM   1181 C CD  . GLU A 1 168 ? 3.65625  5.85950   -12.21701 1.000 39.93168 ? 167 GLU A CD  1 
ATOM   1182 O OE1 . GLU A 1 168 ? 3.86163  4.96240   -11.36860 1.000 43.06993 ? 167 GLU A OE1 1 
ATOM   1183 O OE2 . GLU A 1 168 ? 2.74705  6.71571   -12.12606 1.000 36.42375 ? 167 GLU A OE2 1 
ATOM   1184 N N   . ILE A 1 169 ? 4.01346  7.50615   -17.72766 1.000 20.14375 ? 168 ILE A N   1 
ATOM   1185 C CA  . ILE A 1 169 ? 3.32846  7.82910   -18.98298 1.000 21.58279 ? 168 ILE A CA  1 
ATOM   1186 C C   . ILE A 1 169 ? 4.19186  7.54081   -20.21107 1.000 20.11341 ? 168 ILE A C   1 
ATOM   1187 O O   . ILE A 1 169 ? 3.66534  7.45298   -21.33456 1.000 22.19970 ? 168 ILE A O   1 
ATOM   1188 C CB  . ILE A 1 169 ? 2.88110  9.30249   -18.98186 1.000 20.30065 ? 168 ILE A CB  1 
ATOM   1189 C CG1 . ILE A 1 169 ? 1.72435  9.51996   -19.95514 1.000 26.80436 ? 168 ILE A CG1 1 
ATOM   1190 C CG2 . ILE A 1 169 ? 4.01565  10.22304  -19.32786 1.000 22.67844 ? 168 ILE A CG2 1 
ATOM   1191 C CD1 . ILE A 1 169 ? 0.38437  9.25108   -19.31877 1.000 34.55117 ? 168 ILE A CD1 1 
ATOM   1192 N N   . LEU A 1 170 ? 5.49253  7.35844   -20.02728 1.000 18.53284 ? 169 LEU A N   1 
ATOM   1193 C CA  . LEU A 1 170 ? 6.39162  7.15834   -21.15945 1.000 16.20274 ? 169 LEU A CA  1 
ATOM   1194 C C   . LEU A 1 170 ? 6.16137  5.87208   -21.95828 1.000 19.53696 ? 169 LEU A C   1 
ATOM   1195 O O   . LEU A 1 170 ? 6.33227  5.92174   -23.18755 1.000 21.57598 ? 169 LEU A O   1 
ATOM   1196 C CB  . LEU A 1 170 ? 7.83618  7.24481   -20.64433 1.000 17.40464 ? 169 LEU A CB  1 
ATOM   1197 C CG  . LEU A 1 170 ? 9.01796  7.39796   -21.59712 1.000 23.43460 ? 169 LEU A CG  1 
ATOM   1198 C CD1 . LEU A 1 170 ? 8.78862  8.50426   -22.63463 1.000 21.59944 ? 169 LEU A CD1 1 
ATOM   1199 C CD2 . LEU A 1 170 ? 10.26752 7.68939   -20.76159 1.000 24.51668 ? 169 LEU A CD2 1 
ATOM   1200 N N   . PRO A 1 171 ? 5.81446  4.72190   -21.37363 1.000 18.68023 ? 170 PRO A N   1 
ATOM   1201 C CA  . PRO A 1 171 ? 5.71339  3.48385   -22.17991 1.000 19.48288 ? 170 PRO A CA  1 
ATOM   1202 C C   . PRO A 1 171 ? 4.71774  3.59703   -23.33054 1.000 22.42653 ? 170 PRO A C   1 
ATOM   1203 O O   . PRO A 1 171 ? 5.07108  3.25778   -24.46911 1.000 20.34709 ? 170 PRO A O   1 
ATOM   1204 C CB  . PRO A 1 171 ? 5.29360  2.41831   -21.15375 1.000 20.09454 ? 170 PRO A CB  1 
ATOM   1205 C CG  . PRO A 1 171 ? 5.87185  2.92885   -19.84823 1.000 21.56379 ? 170 PRO A CG  1 
ATOM   1206 C CD  . PRO A 1 171 ? 5.73890  4.42781   -19.92112 1.000 19.15078 ? 170 PRO A CD  1 
ATOM   1207 N N   . PRO A 1 172 ? 3.47653  4.06874   -23.11996 1.000 22.67845 ? 171 PRO A N   1 
ATOM   1208 C CA  . PRO A 1 172 ? 2.57096  4.17397   -24.28414 1.000 24.32456 ? 171 PRO A CA  1 
ATOM   1209 C C   . PRO A 1 172 ? 3.01450  5.21945   -25.29082 1.000 19.24764 ? 171 PRO A C   1 
ATOM   1210 O O   . PRO A 1 172 ? 2.74691  5.07169   -26.49207 1.000 18.95274 ? 171 PRO A O   1 
ATOM   1211 C CB  . PRO A 1 172 ? 1.21431  4.53242   -23.65958 1.000 25.89735 ? 171 PRO A CB  1 
ATOM   1212 C CG  . PRO A 1 172 ? 1.54780  5.12487   -22.34439 1.000 22.73517 ? 171 PRO A CG  1 
ATOM   1213 C CD  . PRO A 1 172 ? 2.76432  4.38817   -21.86250 1.000 22.87758 ? 171 PRO A CD  1 
ATOM   1214 N N   . ILE A 1 173 ? 3.69385  6.26957   -24.83713 1.000 18.21933 ? 172 ILE A N   1 
ATOM   1215 C CA  . ILE A 1 173 ? 4.20644  7.26938   -25.76248 1.000 17.25772 ? 172 ILE A CA  1 
ATOM   1216 C C   . ILE A 1 173 ? 5.27189  6.65856   -26.66104 1.000 17.27901 ? 172 ILE A C   1 
ATOM   1217 O O   . ILE A 1 173 ? 5.26397  6.85526   -27.88307 1.000 15.95383 ? 172 ILE A O   1 
ATOM   1218 C CB  . ILE A 1 173 ? 4.73413  8.48768   -24.99245 1.000 17.38487 ? 172 ILE A CB  1 
ATOM   1219 C CG1 . ILE A 1 173 ? 3.55652  9.28117   -24.42672 1.000 19.06927 ? 172 ILE A CG1 1 
ATOM   1220 C CG2 . ILE A 1 173 ? 5.62299  9.35145   -25.89459 1.000 20.17657 ? 172 ILE A CG2 1 
ATOM   1221 C CD1 . ILE A 1 173 ? 3.96262  10.37481  -23.49133 1.000 20.61997 ? 172 ILE A CD1 1 
ATOM   1222 N N   . LEU A 1 174 ? 6.19968  5.90235   -26.06972 1.000 19.39974 ? 173 LEU A N   1 
ATOM   1223 C CA  . LEU A 1 174 ? 7.21891  5.22587   -26.86553 1.000 22.42063 ? 173 LEU A CA  1 
ATOM   1224 C C   . LEU A 1 174 ? 6.59707  4.22169   -27.83269 1.000 22.81001 ? 173 LEU A C   1 
ATOM   1225 O O   . LEU A 1 174 ? 7.00410  4.14830   -28.99457 1.000 20.50475 ? 173 LEU A O   1 
ATOM   1226 C CB  . LEU A 1 174 ? 8.23626  4.53539   -25.95069 1.000 20.91770 ? 173 LEU A CB  1 
ATOM   1227 C CG  . LEU A 1 174 ? 9.16444  5.46340   -25.15283 1.000 18.81354 ? 173 LEU A CG  1 
ATOM   1228 C CD1 . LEU A 1 174 ? 9.92178  4.66689   -24.09163 1.000 19.92490 ? 173 LEU A CD1 1 
ATOM   1229 C CD2 . LEU A 1 174 ? 10.13863 6.19919   -26.06484 1.000 21.20083 ? 173 LEU A CD2 1 
ATOM   1230 N N   . ASP A 1 175 ? 5.62812  3.42158   -27.36592 1.000 21.07165 ? 174 ASP A N   1 
ATOM   1231 C CA  . ASP A 1 175 ? 4.93150  2.49713   -28.26577 1.000 20.84559 ? 174 ASP A CA  1 
ATOM   1232 C C   . ASP A 1 175 ? 4.32549  3.22639   -29.45892 1.000 22.22740 ? 174 ASP A C   1 
ATOM   1233 O O   . ASP A 1 175 ? 4.42479  2.76184   -30.59963 1.000 22.77641 ? 174 ASP A O   1 
ATOM   1234 C CB  . ASP A 1 175 ? 3.81896  1.75148   -27.52485 1.000 25.63997 ? 174 ASP A CB  1 
ATOM   1235 C CG  . ASP A 1 175 ? 4.33983  0.83503   -26.44875 1.000 37.88384 ? 174 ASP A CG  1 
ATOM   1236 O OD1 . ASP A 1 175 ? 5.55149  0.50841   -26.46418 1.000 37.81554 ? 174 ASP A OD1 1 
ATOM   1237 O OD2 . ASP A 1 175 ? 3.52040  0.44184   -25.58424 1.000 32.60092 ? 174 ASP A OD2 1 
ATOM   1238 N N   . GLU A 1 176 ? 3.68135  4.36630   -29.20937 1.000 19.09630 ? 175 GLU A N   1 
ATOM   1239 C CA  . GLU A 1 176 ? 3.05548  5.13220   -30.28483 1.000 22.05611 ? 175 GLU A CA  1 
ATOM   1240 C C   . GLU A 1 176 ? 4.08990  5.73959   -31.22700 1.000 21.81303 ? 175 GLU A C   1 
ATOM   1241 O O   . GLU A 1 176 ? 3.88986  5.76983   -32.45009 1.000 20.17293 ? 175 GLU A O   1 
ATOM   1242 C CB  . GLU A 1 176 ? 2.17093  6.22265   -29.68268 1.000 21.73232 ? 175 GLU A CB  1 
ATOM   1243 C CG  . GLU A 1 176 ? 1.21442  6.81094   -30.66764 1.000 32.68650 ? 175 GLU A CG  1 
ATOM   1244 C CD  . GLU A 1 176 ? 0.60999  5.75189   -31.56798 1.000 35.50558 ? 175 GLU A CD  1 
ATOM   1245 O OE1 . GLU A 1 176 ? -0.00290 4.77562   -31.07227 1.000 35.49802 ? 175 GLU A OE1 1 
ATOM   1246 O OE2 . GLU A 1 176 ? 0.84110  5.86020   -32.77596 1.000 36.43225 ? 175 GLU A OE2 1 
ATOM   1247 N N   . LEU A 1 177 ? 5.18239  6.26913   -30.68063 1.000 19.85430 ? 176 LEU A N   1 
ATOM   1248 C CA  . LEU A 1 177 ? 6.20569  6.84890   -31.54686 1.000 16.61811 ? 176 LEU A CA  1 
ATOM   1249 C C   . LEU A 1 177 ? 6.82743  5.78432   -32.43894 1.000 16.63259 ? 176 LEU A C   1 
ATOM   1250 O O   . LEU A 1 177 ? 7.14441  6.04983   -33.60298 1.000 19.25264 ? 176 LEU A O   1 
ATOM   1251 C CB  . LEU A 1 177 ? 7.28012  7.53486   -30.70094 1.000 17.11052 ? 176 LEU A CB  1 
ATOM   1252 C CG  . LEU A 1 177 ? 6.84241  8.79521   -29.95908 1.000 18.37810 ? 176 LEU A CG  1 
ATOM   1253 C CD1 . LEU A 1 177 ? 7.95456  9.24415   -29.00415 1.000 20.40458 ? 176 LEU A CD1 1 
ATOM   1254 C CD2 . LEU A 1 177 ? 6.46033  9.92688   -30.89432 1.000 18.89846 ? 176 LEU A CD2 1 
ATOM   1255 N N   . ASP A 1 178 ? 7.01091  4.57319   -31.90613 1.000 17.36090 ? 177 ASP A N   1 
ATOM   1256 C CA  . ASP A 1 178 ? 7.51230  3.46056   -32.70499 1.000 19.41324 ? 177 ASP A CA  1 
ATOM   1257 C C   . ASP A 1 178 ? 6.62207  3.21343   -33.91952 1.000 20.48857 ? 177 ASP A C   1 
ATOM   1258 O O   . ASP A 1 178 ? 7.11570  2.96693   -35.02432 1.000 22.45330 ? 177 ASP A O   1 
ATOM   1259 C CB  . ASP A 1 178 ? 7.57444  2.18307   -31.87254 1.000 23.76006 ? 177 ASP A CB  1 
ATOM   1260 C CG  . ASP A 1 178 ? 8.80631  2.10019   -30.99693 1.000 35.48821 ? 177 ASP A CG  1 
ATOM   1261 O OD1 . ASP A 1 178 ? 9.90978  2.48705   -31.44441 1.000 35.45919 ? 177 ASP A OD1 1 
ATOM   1262 O OD2 . ASP A 1 178 ? 8.66752  1.59409   -29.86134 1.000 36.78900 ? 177 ASP A OD2 1 
ATOM   1263 N N   . ARG A 1 179 ? 5.30203  3.20335   -33.71224 1.000 21.64742 ? 178 ARG A N   1 
ATOM   1264 C CA  . ARG A 1 179 ? 4.38930  2.96006   -34.82862 1.000 22.31583 ? 178 ARG A CA  1 
ATOM   1265 C C   . ARG A 1 179 ? 4.48127  4.07255   -35.85873 1.000 19.30787 ? 178 ARG A C   1 
ATOM   1266 O O   . ARG A 1 179 ? 4.52355  3.81163   -37.06805 1.000 22.28394 ? 178 ARG A O   1 
ATOM   1267 C CB  . ARG A 1 179 ? 2.95151  2.82935   -34.32771 1.000 19.81764 ? 178 ARG A CB  1 
ATOM   1268 C CG  . ARG A 1 179 ? 2.72971  1.77067   -33.27708 1.000 33.66845 ? 178 ARG A CG  1 
ATOM   1269 C CD  . ARG A 1 179 ? 2.83496  0.38127   -33.86811 1.000 39.58242 ? 178 ARG A CD  1 
ATOM   1270 N N   . LEU A 1 180 ? 4.52772  5.32244   -35.39672 1.000 19.65736 ? 179 LEU A N   1 
ATOM   1271 C CA  . LEU A 1 180 ? 4.61505  6.44573   -36.31626 1.000 18.79495 ? 179 LEU A CA  1 
ATOM   1272 C C   . LEU A 1 180 ? 5.92444  6.41429   -37.08539 1.000 19.85420 ? 179 LEU A C   1 
ATOM   1273 O O   . LEU A 1 180 ? 5.95366  6.69363   -38.28767 1.000 18.92669 ? 179 LEU A O   1 
ATOM   1274 C CB  . LEU A 1 180 ? 4.49217  7.75630   -35.54817 1.000 19.14620 ? 179 LEU A CB  1 
ATOM   1275 C CG  . LEU A 1 180 ? 3.11879  8.05476   -34.93480 1.000 19.19666 ? 179 LEU A CG  1 
ATOM   1276 C CD1 . LEU A 1 180 ? 3.16218  9.34862   -34.14522 1.000 23.76726 ? 179 LEU A CD1 1 
ATOM   1277 C CD2 . LEU A 1 180 ? 2.07906  8.13773   -36.04595 1.000 22.91005 ? 179 LEU A CD2 1 
ATOM   1278 N N   . LEU A 1 181 ? 7.02602  6.11110   -36.39207 1.000 17.67346 ? 180 LEU A N   1 
ATOM   1279 C CA  . LEU A 1 181 ? 8.31098  5.97597   -37.06684 1.000 17.40822 ? 180 LEU A CA  1 
ATOM   1280 C C   . LEU A 1 181 ? 8.25095  4.88870   -38.12362 1.000 20.01949 ? 180 LEU A C   1 
ATOM   1281 O O   . LEU A 1 181 ? 8.76541  5.05729   -39.23392 1.000 20.39001 ? 180 LEU A O   1 
ATOM   1282 C CB  . LEU A 1 181 ? 9.39548  5.63525   -36.04727 1.000 16.91852 ? 180 LEU A CB  1 
ATOM   1283 C CG  . LEU A 1 181 ? 9.86102  6.81108   -35.18752 1.000 19.07837 ? 180 LEU A CG  1 
ATOM   1284 C CD1 . LEU A 1 181 ? 10.64230 6.28052   -33.97209 1.000 18.97903 ? 180 LEU A CD1 1 
ATOM   1285 C CD2 . LEU A 1 181 ? 10.68950 7.79594   -35.98542 1.000 18.14909 ? 180 LEU A CD2 1 
ATOM   1286 N N   . SER A 1 182 ? 7.65747  3.75054   -37.77097 1.000 19.03993 ? 181 SER A N   1 
ATOM   1287 C CA  . SER A 1 182 ? 7.60607  2.62190   -38.68161 1.000 21.12959 ? 181 SER A CA  1 
ATOM   1288 C C   . SER A 1 182 ? 6.76899  2.96265   -39.90249 1.000 24.23844 ? 181 SER A C   1 
ATOM   1289 O O   . SER A 1 182 ? 7.15549  2.64907   -41.02554 1.000 22.78704 ? 181 SER A O   1 
ATOM   1290 C CB  . SER A 1 182 ? 7.05033  1.39482   -37.96224 1.000 22.05009 ? 181 SER A CB  1 
ATOM   1291 O OG  . SER A 1 182 ? 7.98390  0.93387   -36.99803 1.000 27.97858 ? 181 SER A OG  1 
ATOM   1292 N N   . GLU A 1 183 ? 5.65319  3.65919   -39.70087 1.000 22.39513 ? 182 GLU A N   1 
ATOM   1293 C CA  . GLU A 1 183 ? 4.78046  3.96218   -40.82351 1.000 25.90637 ? 182 GLU A CA  1 
ATOM   1294 C C   . GLU A 1 183 ? 5.48011  4.89050   -41.81477 1.000 23.60393 ? 182 GLU A C   1 
ATOM   1295 O O   . GLU A 1 183 ? 5.28148  4.75950   -43.02765 1.000 26.25816 ? 182 GLU A O   1 
ATOM   1296 C CB  . GLU A 1 183 ? 3.47911  4.58360   -40.31271 1.000 22.43730 ? 182 GLU A CB  1 
ATOM   1297 C CG  . GLU A 1 183 ? 2.53151  5.03262   -41.41823 1.000 32.14365 ? 182 GLU A CG  1 
ATOM   1298 C CD  . GLU A 1 183 ? 2.30431  3.94168   -42.45523 1.000 40.75547 ? 182 GLU A CD  1 
ATOM   1299 O OE1 . GLU A 1 183 ? 1.94262  2.82418   -42.02686 1.000 42.57408 ? 182 GLU A OE1 1 
ATOM   1300 O OE2 . GLU A 1 183 ? 2.46394  4.18397   -43.67603 1.000 39.42139 ? 182 GLU A OE2 1 
ATOM   1301 N N   . ARG A 1 184 ? 6.35292  5.79506   -41.34496 1.000 21.46129 ? 183 ARG A N   1 
ATOM   1302 C CA  A ARG A 1 184 ? 7.05054  6.64069   -42.31293 0.326 21.23935 ? 183 ARG A CA  1 
ATOM   1303 C CA  B ARG A 1 184 ? 7.12625  6.71307   -42.16745 0.674 21.01373 ? 183 ARG A CA  1 
ATOM   1304 C C   . ARG A 1 184 ? 8.45072  6.13829   -42.64392 1.000 21.99447 ? 183 ARG A C   1 
ATOM   1305 O O   . ARG A 1 184 ? 9.24569  6.88467   -43.22050 1.000 21.36619 ? 183 ARG A O   1 
ATOM   1306 C CB  A ARG A 1 184 ? 7.10576  8.10894   -41.87661 0.326 22.03806 ? 183 ARG A CB  1 
ATOM   1307 C CB  B ARG A 1 184 ? 7.41515  8.00863   -41.39486 0.674 19.94914 ? 183 ARG A CB  1 
ATOM   1308 C CG  A ARG A 1 184 ? 7.12315  8.41292   -40.41206 0.326 23.72466 ? 183 ARG A CG  1 
ATOM   1309 C CG  B ARG A 1 184 ? 6.19973  8.79104   -40.93316 0.674 21.98168 ? 183 ARG A CG  1 
ATOM   1310 C CD  A ARG A 1 184 ? 6.45457  9.76866   -40.17361 0.326 21.81473 ? 183 ARG A CD  1 
ATOM   1311 C CD  B ARG A 1 184 ? 6.55724  10.27172  -40.79074 0.674 24.18293 ? 183 ARG A CD  1 
ATOM   1312 N NE  A ARG A 1 184 ? 7.19866  10.85845  -40.79417 0.326 22.39816 ? 183 ARG A NE  1 
ATOM   1313 N NE  B ARG A 1 184 ? 5.71612  10.94598  -39.81215 0.674 22.69820 ? 183 ARG A NE  1 
ATOM   1314 C CZ  A ARG A 1 184 ? 7.31560  12.07509  -40.28203 0.326 21.31073 ? 183 ARG A CZ  1 
ATOM   1315 C CZ  B ARG A 1 184 ? 5.95344  12.14990  -39.30738 0.674 20.28697 ? 183 ARG A CZ  1 
ATOM   1316 N NH1 A ARG A 1 184 ? 6.69803  12.41665  -39.16175 0.326 20.45025 ? 183 ARG A NH1 1 
ATOM   1317 N NH1 B ARG A 1 184 ? 7.02863  12.84536  -39.64743 0.674 22.02469 ? 183 ARG A NH1 1 
ATOM   1318 N NH2 A ARG A 1 184 ? 8.06685  12.97261  -40.91173 0.326 26.16874 ? 183 ARG A NH2 1 
ATOM   1319 N NH2 B ARG A 1 184 ? 5.06107  12.69143  -38.48391 0.674 20.64178 ? 183 ARG A NH2 1 
ATOM   1320 N N   . GLN A 1 185 ? 8.73467  4.86697   -42.36607 1.000 21.01718 ? 184 GLN A N   1 
ATOM   1321 C CA  . GLN A 1 185 ? 9.99627  4.24705   -42.76852 1.000 19.33647 ? 184 GLN A CA  1 
ATOM   1322 C C   . GLN A 1 185 ? 11.19061 4.96835   -42.14785 1.000 20.67019 ? 184 GLN A C   1 
ATOM   1323 O O   . GLN A 1 185 ? 12.27247 5.03691   -42.73489 1.000 21.45219 ? 184 GLN A O   1 
ATOM   1324 C CB  . GLN A 1 185 ? 10.09917 4.19199   -44.30069 1.000 22.48541 ? 184 GLN A CB  1 
ATOM   1325 C CG  . GLN A 1 185 ? 8.94586  3.37602   -44.88510 1.000 28.05240 ? 184 GLN A CG  1 
ATOM   1326 C CD  . GLN A 1 185 ? 9.14800  2.97485   -46.33688 1.000 43.27966 ? 184 GLN A CD  1 
ATOM   1327 O OE1 . GLN A 1 185 ? 9.96918  2.11656   -46.66468 1.000 44.26242 ? 184 GLN A OE1 1 
ATOM   1328 N NE2 . GLN A 1 185 ? 8.37498  3.59538   -47.21763 1.000 54.21075 ? 184 GLN A NE2 1 
ATOM   1329 N N   . LEU A 1 186 ? 10.99790 5.52285   -40.94870 1.000 18.70936 ? 185 LEU A N   1 
ATOM   1330 C CA  . LEU A 1 186 ? 12.07876 6.17629   -40.21728 1.000 20.34070 ? 185 LEU A CA  1 
ATOM   1331 C C   . LEU A 1 186 ? 12.47531 5.43066   -38.95744 1.000 19.03600 ? 185 LEU A C   1 
ATOM   1332 O O   . LEU A 1 186 ? 13.28720 5.94956   -38.17718 1.000 19.70421 ? 185 LEU A O   1 
ATOM   1333 C CB  . LEU A 1 186 ? 11.71551 7.61746   -39.84993 1.000 18.15031 ? 185 LEU A CB  1 
ATOM   1334 C CG  . LEU A 1 186 ? 11.42725 8.59686   -40.97831 1.000 25.03732 ? 185 LEU A CG  1 
ATOM   1335 C CD1 . LEU A 1 186 ? 10.68101 9.80002   -40.42183 1.000 29.15024 ? 185 LEU A CD1 1 
ATOM   1336 C CD2 . LEU A 1 186 ? 12.76844 9.00661   -41.58251 1.000 22.32038 ? 185 LEU A CD2 1 
ATOM   1337 N N   . ARG A 1 187 ? 11.91815 4.23876   -38.72013 1.000 18.51334 ? 186 ARG A N   1 
ATOM   1338 C CA  . ARG A 1 187 ? 12.25504 3.52437   -37.48858 1.000 21.31463 ? 186 ARG A CA  1 
ATOM   1339 C C   . ARG A 1 187 ? 13.70613 3.05576   -37.49684 1.000 19.85372 ? 186 ARG A C   1 
ATOM   1340 O O   . ARG A 1 187 ? 14.38372 3.10659   -36.46723 1.000 18.05639 ? 186 ARG A O   1 
ATOM   1341 C CB  . ARG A 1 187 ? 11.32993 2.32721   -37.27068 1.000 24.89843 ? 186 ARG A CB  1 
ATOM   1342 C CG  . ARG A 1 187 ? 11.68988 1.52150   -35.98849 1.000 27.44884 ? 186 ARG A CG  1 
ATOM   1343 C CD  . ARG A 1 187 ? 10.49746 1.06622   -35.16732 1.000 27.69216 ? 186 ARG A CD  1 
ATOM   1344 N NE  . ARG A 1 187 ? 10.82063 0.91175   -33.75119 1.000 32.22326 ? 186 ARG A NE  1 
ATOM   1345 C CZ  . ARG A 1 187 ? 11.60632 -0.03545  -33.25014 1.000 29.25020 ? 186 ARG A CZ  1 
ATOM   1346 N NH1 . ARG A 1 187 ? 12.21059 -0.92143  -34.02822 1.000 32.74062 ? 186 ARG A NH1 1 
ATOM   1347 N NH2 . ARG A 1 187 ? 11.80031 -0.08734  -31.93179 1.000 34.91698 ? 186 ARG A NH2 1 
ATOM   1348 N N   . GLU A 1 188 ? 14.21613 2.60426   -38.64736 1.000 22.79088 ? 187 GLU A N   1 
ATOM   1349 C CA  . GLU A 1 188 ? 15.60755 2.15972   -38.67252 1.000 19.55265 ? 187 GLU A CA  1 
ATOM   1350 C C   . GLU A 1 188 ? 16.55398 3.30700   -38.35805 1.000 17.70519 ? 187 GLU A C   1 
ATOM   1351 O O   . GLU A 1 188 ? 17.58800 3.10877   -37.70989 1.000 18.97830 ? 187 GLU A O   1 
ATOM   1352 C CB  . GLU A 1 188 ? 15.95935 1.54986   -40.03216 1.000 20.42508 ? 187 GLU A CB  1 
ATOM   1353 C CG  . GLU A 1 188 ? 15.30580 0.20244   -40.28886 1.000 28.34017 ? 187 GLU A CG  1 
ATOM   1354 C CD  . GLU A 1 188 ? 15.60270 -0.30365  -41.68723 1.000 49.88042 ? 187 GLU A CD  1 
ATOM   1355 O OE1 . GLU A 1 188 ? 14.64509 -0.54192  -42.45415 1.000 59.09686 ? 187 GLU A OE1 1 
ATOM   1356 O OE2 . GLU A 1 188 ? 16.80197 -0.43955  -42.02026 1.000 48.34055 ? 187 GLU A OE2 1 
ATOM   1357 N N   . LEU A 1 189 ? 16.22557 4.51369   -38.82295 1.000 18.58518 ? 188 LEU A N   1 
ATOM   1358 C CA  . LEU A 1 189 ? 17.04344 5.67431   -38.49592 1.000 16.54466 ? 188 LEU A CA  1 
ATOM   1359 C C   . LEU A 1 189 ? 16.98392 5.98077   -37.00161 1.000 16.66090 ? 188 LEU A C   1 
ATOM   1360 O O   . LEU A 1 189 ? 18.01429 6.27519   -36.36910 1.000 14.79443 ? 188 LEU A O   1 
ATOM   1361 C CB  . LEU A 1 189 ? 16.57451 6.87610   -39.30631 1.000 17.87465 ? 188 LEU A CB  1 
ATOM   1362 C CG  . LEU A 1 189 ? 17.35711 8.17640   -39.12555 1.000 17.16165 ? 188 LEU A CG  1 
ATOM   1363 C CD1 . LEU A 1 189 ? 18.87186 7.95207   -39.31925 1.000 20.39978 ? 188 LEU A CD1 1 
ATOM   1364 C CD2 . LEU A 1 189 ? 16.79504 9.26380   -40.05982 1.000 20.55027 ? 188 LEU A CD2 1 
ATOM   1365 N N   . ALA A 1 190 ? 15.78122 5.91189   -36.41692 1.000 14.35377 ? 189 ALA A N   1 
ATOM   1366 C CA  . ALA A 1 190 ? 15.66994 6.13010   -34.97647 1.000 15.61446 ? 189 ALA A CA  1 
ATOM   1367 C C   . ALA A 1 190 ? 16.43737 5.07270   -34.20086 1.000 16.90189 ? 189 ALA A C   1 
ATOM   1368 O O   . ALA A 1 190 ? 17.09733 5.38629   -33.20637 1.000 16.85492 ? 189 ALA A O   1 
ATOM   1369 C CB  . ALA A 1 190 ? 14.20007 6.14021   -34.53650 1.000 20.06937 ? 189 ALA A CB  1 
ATOM   1370 N N   . VAL A 1 191 ? 16.32849 3.80668   -34.61459 1.000 17.77504 ? 190 VAL A N   1 
ATOM   1371 C CA  . VAL A 1 191 ? 17.07791 2.74193   -33.95293 1.000 19.40546 ? 190 VAL A CA  1 
ATOM   1372 C C   . VAL A 1 191 ? 18.56875 3.04282   -34.00189 1.000 18.88419 ? 190 VAL A C   1 
ATOM   1373 O O   . VAL A 1 191 ? 19.27821 2.90304   -32.99927 1.000 17.41395 ? 190 VAL A O   1 
ATOM   1374 C CB  . VAL A 1 191 ? 16.73770 1.37992   -34.59205 1.000 19.12656 ? 190 VAL A CB  1 
ATOM   1375 C CG1 . VAL A 1 191 ? 17.73061 0.30965   -34.19346 1.000 19.57517 ? 190 VAL A CG1 1 
ATOM   1376 C CG2 . VAL A 1 191 ? 15.32032 0.96261   -34.21973 1.000 19.86328 ? 190 VAL A CG2 1 
ATOM   1377 N N   . ALA A 1 192 ? 19.06045 3.49395   -35.16094 1.000 15.18197 ? 191 ALA A N   1 
ATOM   1378 C CA  . ALA A 1 192 ? 20.46989 3.85472   -35.26281 1.000 19.83580 ? 191 ALA A CA  1 
ATOM   1379 C C   . ALA A 1 192 ? 20.81338 5.03384   -34.35753 1.000 18.23063 ? 191 ALA A C   1 
ATOM   1380 O O   . ALA A 1 192 ? 21.88485 5.06191   -33.74638 1.000 17.16111 ? 191 ALA A O   1 
ATOM   1381 C CB  . ALA A 1 192 ? 20.81836 4.16449   -36.71735 1.000 19.87436 ? 191 ALA A CB  1 
ATOM   1382 N N   . CYS A 1 193 ? 19.92413 6.02293   -34.26343 1.000 15.94997 ? 192 CYS A N   1 
ATOM   1383 C CA  . CYS A 1 193 ? 20.20520 7.17749   -33.41768 1.000 19.38236 ? 192 CYS A CA  1 
ATOM   1384 C C   . CYS A 1 193 ? 20.17842 6.79838   -31.94273 1.000 16.93201 ? 192 CYS A C   1 
ATOM   1385 O O   . CYS A 1 193 ? 21.06392 7.19785   -31.16702 1.000 15.63636 ? 192 CYS A O   1 
ATOM   1386 C CB  . CYS A 1 193 ? 19.20807 8.28666   -33.71849 1.000 17.95272 ? 192 CYS A CB  1 
ATOM   1387 S SG  . CYS A 1 193 ? 19.55124 9.07347   -35.31651 1.000 20.39785 ? 192 CYS A SG  1 
ATOM   1388 N N   . TRP A 1 194 ? 19.20168 5.98810   -31.54715 1.000 15.32286 ? 193 TRP A N   1 
ATOM   1389 C CA  . TRP A 1 194 ? 19.17212 5.51692   -30.16259 1.000 15.27179 ? 193 TRP A CA  1 
ATOM   1390 C C   . TRP A 1 194 ? 20.43633 4.74244   -29.82562 1.000 17.35150 ? 193 TRP A C   1 
ATOM   1391 O O   . TRP A 1 194 ? 20.97974 4.87591   -28.72425 1.000 15.60909 ? 193 TRP A O   1 
ATOM   1392 C CB  . TRP A 1 194 ? 17.95705 4.63136   -29.94962 1.000 14.88312 ? 193 TRP A CB  1 
ATOM   1393 C CG  . TRP A 1 194 ? 16.64216 5.34059   -30.04046 1.000 15.71298 ? 193 TRP A CG  1 
ATOM   1394 C CD1 . TRP A 1 194 ? 16.37313 6.64697   -29.73409 1.000 13.31178 ? 193 TRP A CD1 1 
ATOM   1395 C CD2 . TRP A 1 194 ? 15.40664 4.76251   -30.47689 1.000 13.67036 ? 193 TRP A CD2 1 
ATOM   1396 N NE1 . TRP A 1 194 ? 15.02790 6.90183   -29.91473 1.000 14.38317 ? 193 TRP A NE1 1 
ATOM   1397 C CE2 . TRP A 1 194 ? 14.41730 5.75837   -30.36643 1.000 16.39275 ? 193 TRP A CE2 1 
ATOM   1398 C CE3 . TRP A 1 194 ? 15.03871 3.48632   -30.91891 1.000 15.09764 ? 193 TRP A CE3 1 
ATOM   1399 C CZ2 . TRP A 1 194 ? 13.08138 5.53081   -30.72604 1.000 20.36215 ? 193 TRP A CZ2 1 
ATOM   1400 C CZ3 . TRP A 1 194 ? 13.70340 3.25639   -31.28031 1.000 19.81907 ? 193 TRP A CZ3 1 
ATOM   1401 C CH2 . TRP A 1 194 ? 12.74610 4.27730   -31.18237 1.000 23.87962 ? 193 TRP A CH2 1 
ATOM   1402 N N   . HIS A 1 195 ? 20.92252 3.93386   -30.77422 1.000 16.29333 ? 194 HIS A N   1 
ATOM   1403 C CA  . HIS A 1 195 ? 22.15502 3.18830   -30.55654 1.000 19.03068 ? 194 HIS A CA  1 
ATOM   1404 C C   . HIS A 1 195 ? 23.33572 4.12075   -30.30433 1.000 15.64647 ? 194 HIS A C   1 
ATOM   1405 O O   . HIS A 1 195 ? 24.26690 3.76058   -29.58123 1.000 18.40342 ? 194 HIS A O   1 
ATOM   1406 C CB  . HIS A 1 195 ? 22.43826 2.29175   -31.76671 1.000 17.35133 ? 194 HIS A CB  1 
ATOM   1407 C CG  . HIS A 1 195 ? 23.54836 1.31506   -31.53235 1.000 22.00966 ? 194 HIS A CG  1 
ATOM   1408 N ND1 . HIS A 1 195 ? 24.82666 1.50998   -32.00997 1.000 27.61275 ? 194 HIS A ND1 1 
ATOM   1409 C CD2 . HIS A 1 195 ? 23.57166 0.13796   -30.86554 1.000 25.37934 ? 194 HIS A CD2 1 
ATOM   1410 C CE1 . HIS A 1 195 ? 25.59149 0.49652   -31.64267 1.000 24.93622 ? 194 HIS A CE1 1 
ATOM   1411 N NE2 . HIS A 1 195 ? 24.85430 -0.35059  -30.94938 1.000 29.37191 ? 194 HIS A NE2 1 
ATOM   1412 N N   . HIS A 1 196 ? 23.30955 5.32057   -30.87782 1.000 15.18310 ? 195 HIS A N   1 
ATOM   1413 C CA  . HIS A 1 196 ? 24.41869 6.25985   -30.74166 1.000 15.43519 ? 195 HIS A CA  1 
ATOM   1414 C C   . HIS A 1 196 ? 24.39549 7.02957   -29.42504 1.000 16.30019 ? 195 HIS A C   1 
ATOM   1415 O O   . HIS A 1 196 ? 25.41891 7.61922   -29.05608 1.000 15.21261 ? 195 HIS A O   1 
ATOM   1416 C CB  . HIS A 1 196 ? 24.41073 7.25606   -31.91219 1.000 17.21902 ? 195 HIS A CB  1 
ATOM   1417 C CG  . HIS A 1 196 ? 25.55006 8.23072   -31.89170 1.000 15.44448 ? 195 HIS A CG  1 
ATOM   1418 N ND1 . HIS A 1 196 ? 26.87122 7.83440   -31.94939 1.000 16.45419 ? 195 HIS A ND1 1 
ATOM   1419 C CD2 . HIS A 1 196 ? 25.56434 9.58391   -31.83104 1.000 16.51954 ? 195 HIS A CD2 1 
ATOM   1420 C CE1 . HIS A 1 196 ? 27.64771 8.90507   -31.92804 1.000 18.64764 ? 195 HIS A CE1 1 
ATOM   1421 N NE2 . HIS A 1 196 ? 26.88108 9.97881   -31.85916 1.000 14.52980 ? 195 HIS A NE2 1 
ATOM   1422 N N   . ILE A 1 197 ? 23.26014 7.06158   -28.71846 1.000 15.28056 ? 196 ILE A N   1 
ATOM   1423 C CA  . ILE A 1 197 ? 23.14322 7.95197   -27.56182 1.000 16.15475 ? 196 ILE A CA  1 
ATOM   1424 C C   . ILE A 1 197 ? 24.29148 7.77036   -26.57838 1.000 11.99546 ? 196 ILE A C   1 
ATOM   1425 O O   . ILE A 1 197 ? 24.86436 8.77722   -26.15132 1.000 15.01658 ? 196 ILE A O   1 
ATOM   1426 C CB  . ILE A 1 197 ? 21.76582 7.79241   -26.89648 1.000 13.87667 ? 196 ILE A CB  1 
ATOM   1427 C CG1 . ILE A 1 197 ? 20.67451 8.38870   -27.78598 1.000 13.84989 ? 196 ILE A CG1 1 
ATOM   1428 C CG2 . ILE A 1 197 ? 21.75113 8.51135   -25.52939 1.000 14.80235 ? 196 ILE A CG2 1 
ATOM   1429 C CD1 . ILE A 1 197 ? 19.27334 8.03003   -27.30745 1.000 15.02025 ? 196 ILE A CD1 1 
ATOM   1430 N N   . PRO A 1 198 ? 24.66413 6.55293   -26.17375 1.000 15.24537 ? 197 PRO A N   1 
ATOM   1431 C CA  . PRO A 1 198 ? 25.76654 6.42610   -25.20132 1.000 18.42566 ? 197 PRO A CA  1 
ATOM   1432 C C   . PRO A 1 198 ? 27.08849 6.96168   -25.71807 1.000 21.31448 ? 197 PRO A C   1 
ATOM   1433 O O   . PRO A 1 198 ? 27.85539 7.57085   -24.95267 1.000 16.07509 ? 197 PRO A O   1 
ATOM   1434 C CB  . PRO A 1 198 ? 25.82162 4.91242   -24.93757 1.000 16.55293 ? 197 PRO A CB  1 
ATOM   1435 C CG  . PRO A 1 198 ? 24.41892 4.43129   -25.23799 1.000 16.86914 ? 197 PRO A CG  1 
ATOM   1436 C CD  . PRO A 1 198 ? 24.00736 5.25520   -26.41862 1.000 17.46991 ? 197 PRO A CD  1 
ATOM   1437 N N   . ALA A 1 199 ? 27.37909 6.76500   -27.01058 1.000 15.92977 ? 198 ALA A N   1 
ATOM   1438 C CA  . ALA A 1 199 ? 28.59530 7.35790   -27.55152 1.000 18.37120 ? 198 ALA A CA  1 
ATOM   1439 C C   . ALA A 1 199 ? 28.50463 8.87669   -27.54181 1.000 15.72977 ? 198 ALA A C   1 
ATOM   1440 O O   . ALA A 1 199 ? 29.48622 9.55681   -27.23551 1.000 16.14829 ? 198 ALA A O   1 
ATOM   1441 C CB  . ALA A 1 199 ? 28.85925 6.83320   -28.96652 1.000 17.76899 ? 198 ALA A CB  1 
ATOM   1442 N N   . HIS A 1 200 ? 27.33152 9.43370   -27.85589 1.000 15.05539 ? 199 HIS A N   1 
ATOM   1443 C CA  . HIS A 1 200 ? 27.19137 10.88414  -27.79258 1.000 15.36619 ? 199 HIS A CA  1 
ATOM   1444 C C   . HIS A 1 200 ? 27.42548 11.38888  -26.37295 1.000 17.65576 ? 199 HIS A C   1 
ATOM   1445 O O   . HIS A 1 200 ? 28.06965 12.42719  -26.16161 1.000 15.69823 ? 199 HIS A O   1 
ATOM   1446 C CB  . HIS A 1 200 ? 25.80745 11.30394  -28.26589 1.000 17.05424 ? 199 HIS A CB  1 
ATOM   1447 C CG  . HIS A 1 200 ? 25.63054 12.78258  -28.31119 1.000 19.19863 ? 199 HIS A CG  1 
ATOM   1448 N ND1 . HIS A 1 200 ? 26.18630 13.56434  -29.30154 1.000 20.89164 ? 199 HIS A ND1 1 
ATOM   1449 C CD2 . HIS A 1 200 ? 24.99412 13.63097  -27.46664 1.000 17.36428 ? 199 HIS A CD2 1 
ATOM   1450 C CE1 . HIS A 1 200 ? 25.88209 14.82967  -29.07763 1.000 25.27789 ? 199 HIS A CE1 1 
ATOM   1451 N NE2 . HIS A 1 200 ? 25.15638 14.89640  -27.97377 1.000 23.04343 ? 199 HIS A NE2 1 
ATOM   1452 N N   . VAL A 1 201 ? 26.88158 10.67468  -25.39735 1.000 16.80264 ? 200 VAL A N   1 
ATOM   1453 C CA  . VAL A 1 201 ? 27.12655 11.02393  -23.99500 1.000 14.50438 ? 200 VAL A CA  1 
ATOM   1454 C C   . VAL A 1 201 ? 28.61918 10.98848  -23.68093 1.000 18.78152 ? 200 VAL A C   1 
ATOM   1455 O O   . VAL A 1 201 ? 29.14252 11.88167  -23.00099 1.000 17.78815 ? 200 VAL A O   1 
ATOM   1456 C CB  . VAL A 1 201 ? 26.31513 10.09375  -23.07581 1.000 17.44505 ? 200 VAL A CB  1 
ATOM   1457 C CG1 . VAL A 1 201 ? 26.73386 10.29667  -21.59264 1.000 18.31249 ? 200 VAL A CG1 1 
ATOM   1458 C CG2 . VAL A 1 201 ? 24.81701 10.38516  -23.24508 1.000 20.52872 ? 200 VAL A CG2 1 
ATOM   1459 N N   . GLU A 1 202 ? 29.33312 9.97496   -24.19203 1.000 19.45275 ? 201 GLU A N   1 
ATOM   1460 C CA  . GLU A 1 202 ? 30.78672 9.90854   -24.01367 1.000 22.24657 ? 201 GLU A CA  1 
ATOM   1461 C C   . GLU A 1 202 ? 31.48933 11.10774  -24.63608 1.000 19.60180 ? 201 GLU A C   1 
ATOM   1462 O O   . GLU A 1 202 ? 32.44817 11.64113  -24.06362 1.000 22.59723 ? 201 GLU A O   1 
ATOM   1463 C CB  . GLU A 1 202 ? 31.35308 8.63507   -24.63731 1.000 21.54812 ? 201 GLU A CB  1 
ATOM   1464 C CG  . GLU A 1 202 ? 31.16198 7.35705   -23.88276 1.000 28.71736 ? 201 GLU A CG  1 
ATOM   1465 C CD  . GLU A 1 202 ? 31.57728 7.46065   -22.42367 1.000 26.38713 ? 201 GLU A CD  1 
ATOM   1466 O OE1 . GLU A 1 202 ? 32.79237 7.48751   -22.11448 1.000 36.93347 ? 201 GLU A OE1 1 
ATOM   1467 O OE2 . GLU A 1 202 ? 30.66948 7.52854   -21.60055 1.000 25.72914 ? 201 GLU A OE2 1 
ATOM   1468 N N   . LEU A 1 203 ? 31.07596 11.49964  -25.84362 1.000 19.90464 ? 202 LEU A N   1 
ATOM   1469 C CA  . LEU A 1 203 ? 31.66718 12.67389  -26.48352 1.000 18.02917 ? 202 LEU A CA  1 
ATOM   1470 C C   . LEU A 1 203 ? 31.48128 13.92758  -25.63164 1.000 22.13331 ? 202 LEU A C   1 
ATOM   1471 O O   . LEU A 1 203 ? 32.39646 14.74948  -25.51852 1.000 20.97579 ? 202 LEU A O   1 
ATOM   1472 C CB  . LEU A 1 203 ? 31.04834 12.89195  -27.86494 1.000 18.46890 ? 202 LEU A CB  1 
ATOM   1473 C CG  . LEU A 1 203 ? 31.38740 11.84386  -28.92866 1.000 17.91972 ? 202 LEU A CG  1 
ATOM   1474 C CD1 . LEU A 1 203 ? 30.58696 12.13350  -30.16354 1.000 17.34189 ? 202 LEU A CD1 1 
ATOM   1475 C CD2 . LEU A 1 203 ? 32.87599 11.85654  -29.24210 1.000 19.34061 ? 202 LEU A CD2 1 
ATOM   1476 N N   . LEU A 1 204 ? 30.29033 14.10819  -25.05604 1.000 18.80524 ? 203 LEU A N   1 
ATOM   1477 C CA  . LEU A 1 204 ? 30.06007 15.24911  -24.17100 1.000 18.56016 ? 203 LEU A CA  1 
ATOM   1478 C C   . LEU A 1 204 ? 30.91556 15.16062  -22.91005 1.000 17.86837 ? 203 LEU A C   1 
ATOM   1479 O O   . LEU A 1 204 ? 31.46189 16.17225  -22.45684 1.000 22.99869 ? 203 LEU A O   1 
ATOM   1480 C CB  . LEU A 1 204 ? 28.58334 15.33391  -23.78793 1.000 19.47126 ? 203 LEU A CB  1 
ATOM   1481 C CG  . LEU A 1 204 ? 27.62193 15.61497  -24.94268 1.000 19.99214 ? 203 LEU A CG  1 
ATOM   1482 C CD1 . LEU A 1 204 ? 26.17617 15.54564  -24.47988 1.000 21.68120 ? 203 LEU A CD1 1 
ATOM   1483 C CD2 . LEU A 1 204 ? 27.92874 16.96118  -25.56540 1.000 25.24238 ? 203 LEU A CD2 1 
ATOM   1484 N N   . GLU A 1 205 ? 31.01434 13.96937  -22.31745 1.000 21.24784 ? 204 GLU A N   1 
ATOM   1485 C CA  . GLU A 1 205 ? 31.86611 13.78241  -21.13292 1.000 23.60242 ? 204 GLU A CA  1 
ATOM   1486 C C   . GLU A 1 205 ? 33.30576 14.19917  -21.39275 1.000 26.58432 ? 204 GLU A C   1 
ATOM   1487 O O   . GLU A 1 205 ? 33.95917 14.77156  -20.51287 1.000 24.35436 ? 204 GLU A O   1 
ATOM   1488 C CB  . GLU A 1 205 ? 31.81525 12.33128  -20.66978 1.000 19.76901 ? 204 GLU A CB  1 
ATOM   1489 C CG  . GLU A 1 205 ? 32.41279 12.02571  -19.27406 1.000 23.39542 ? 204 GLU A CG  1 
ATOM   1490 C CD  . GLU A 1 205 ? 31.94285 12.92897  -18.14812 1.000 30.82905 ? 204 GLU A CD  1 
ATOM   1491 O OE1 . GLU A 1 205 ? 30.73353 13.17328  -18.02558 1.000 27.66608 ? 204 GLU A OE1 1 
ATOM   1492 O OE2 . GLU A 1 205 ? 32.82664 13.36591  -17.34557 1.000 32.52736 ? 204 GLU A OE2 1 
ATOM   1493 N N   . HIS A 1 206 ? 33.82420 13.91196  -22.58025 1.000 21.03660 ? 205 HIS A N   1 
ATOM   1494 C CA  . HIS A 1 206 ? 35.20212 14.24727  -22.90297 1.000 24.28847 ? 205 HIS A CA  1 
ATOM   1495 C C   . HIS A 1 206 ? 35.36972 15.62819  -23.54666 1.000 23.29003 ? 205 HIS A C   1 
ATOM   1496 O O   . HIS A 1 206 ? 36.48003 15.95429  -23.98473 1.000 20.41070 ? 205 HIS A O   1 
ATOM   1497 C CB  . HIS A 1 206 ? 35.80314 13.18127  -23.82449 1.000 24.07684 ? 205 HIS A CB  1 
ATOM   1498 C CG  . HIS A 1 206 ? 35.91664 11.82475  -23.20060 1.000 29.94233 ? 205 HIS A CG  1 
ATOM   1499 N ND1 . HIS A 1 206 ? 34.89858 11.24371  -22.47680 1.000 37.82243 ? 205 HIS A ND1 1 
ATOM   1500 C CD2 . HIS A 1 206 ? 36.96162 10.96674  -23.13215 1.000 38.99375 ? 205 HIS A CD2 1 
ATOM   1501 C CE1 . HIS A 1 206 ? 35.29402 10.06321  -22.03332 1.000 40.47326 ? 205 HIS A CE1 1 
ATOM   1502 N NE2 . HIS A 1 206 ? 36.54426 9.87327   -22.41307 1.000 46.17830 ? 205 HIS A NE2 1 
ATOM   1503 N N   . ASN A 1 207 ? 34.30826 16.43725  -23.62017 1.000 22.08499 ? 206 ASN A N   1 
ATOM   1504 C CA  . ASN A 1 207 ? 34.34453 17.74446  -24.29648 1.000 22.22632 ? 206 ASN A CA  1 
ATOM   1505 C C   . ASN A 1 207 ? 34.83835 17.63014  -25.73957 1.000 23.43225 ? 206 ASN A C   1 
ATOM   1506 O O   . ASN A 1 207 ? 35.65832 18.42224  -26.21105 1.000 24.41848 ? 206 ASN A O   1 
ATOM   1507 C CB  . ASN A 1 207 ? 35.20732 18.74616  -23.53254 1.000 24.08709 ? 206 ASN A CB  1 
ATOM   1508 C CG  . ASN A 1 207 ? 34.58402 19.17040  -22.23698 1.000 28.15601 ? 206 ASN A CG  1 
ATOM   1509 O OD1 . ASN A 1 207 ? 33.38899 18.97980  -22.02351 1.000 28.77824 ? 206 ASN A OD1 1 
ATOM   1510 N ND2 . ASN A 1 207 ? 35.38514 19.77572  -21.36372 1.000 30.29501 ? 206 ASN A ND2 1 
ATOM   1511 N N   . LEU A 1 208 ? 34.31842 16.64552  -26.45513 1.000 19.84965 ? 207 LEU A N   1 
ATOM   1512 C CA  . LEU A 1 208 ? 34.80372 16.40512  -27.80846 1.000 23.55268 ? 207 LEU A CA  1 
ATOM   1513 C C   . LEU A 1 208 ? 33.95536 17.07400  -28.88569 1.000 29.58858 ? 207 LEU A C   1 
ATOM   1514 O O   . LEU A 1 208 ? 34.42135 17.20326  -30.02536 1.000 30.35059 ? 207 LEU A O   1 
ATOM   1515 C CB  . LEU A 1 208 ? 34.91758 14.89692  -28.04547 1.000 19.03451 ? 207 LEU A CB  1 
ATOM   1516 C CG  . LEU A 1 208 ? 36.11895 14.35977  -27.26653 1.000 21.74600 ? 207 LEU A CG  1 
ATOM   1517 C CD1 . LEU A 1 208 ? 36.37603 12.86981  -27.47678 1.000 22.38963 ? 207 LEU A CD1 1 
ATOM   1518 C CD2 . LEU A 1 208 ? 37.37881 15.17216  -27.57731 1.000 23.25713 ? 207 LEU A CD2 1 
ATOM   1519 N N   . GLY A 1 209 ? 32.75051 17.53830  -28.55458 1.000 29.71382 ? 208 GLY A N   1 
ATOM   1520 C CA  . GLY A 1 209 ? 32.01961 18.35750  -29.51308 1.000 31.64290 ? 208 GLY A CA  1 
ATOM   1521 C C   . GLY A 1 209 ? 31.47195 17.54782  -30.67863 1.000 28.95583 ? 208 GLY A C   1 
ATOM   1522 O O   . GLY A 1 209 ? 31.17412 16.35709  -30.55838 1.000 29.94655 ? 208 GLY A O   1 
ATOM   1523 N N   . ASP A 1 210 ? 31.33357 18.20886  -31.82771 1.000 27.62761 ? 209 ASP A N   1 
ATOM   1524 C CA  . ASP A 1 210 ? 30.73904 17.57768  -33.00932 1.000 30.18091 ? 209 ASP A CA  1 
ATOM   1525 C C   . ASP A 1 210 ? 31.86524 16.98978  -33.84627 1.000 30.39745 ? 209 ASP A C   1 
ATOM   1526 O O   . ASP A 1 210 ? 32.55224 17.70413  -34.57972 1.000 28.42740 ? 209 ASP A O   1 
ATOM   1527 C CB  . ASP A 1 210 ? 29.90461 18.57380  -33.80927 1.000 30.16143 ? 209 ASP A CB  1 
ATOM   1528 C CG  . ASP A 1 210 ? 29.12975 17.91688  -34.95159 1.000 28.73737 ? 209 ASP A CG  1 
ATOM   1529 O OD1 . ASP A 1 210 ? 29.29736 16.69903  -35.18312 1.000 27.59943 ? 209 ASP A OD1 1 
ATOM   1530 O OD2 . ASP A 1 210 ? 28.32245 18.62169  -35.60407 1.000 36.20166 ? 209 ASP A OD2 1 
ATOM   1531 N N   . VAL A 1 211 ? 32.04952 15.66975  -33.74755 1.000 25.01869 ? 210 VAL A N   1 
ATOM   1532 C CA  . VAL A 1 211 ? 33.10824 15.02214  -34.51100 1.000 22.44715 ? 210 VAL A CA  1 
ATOM   1533 C C   . VAL A 1 211 ? 32.67680 14.70397  -35.93205 1.000 19.94632 ? 210 VAL A C   1 
ATOM   1534 O O   . VAL A 1 211 ? 33.48037 14.15196  -36.69416 1.000 23.69792 ? 210 VAL A O   1 
ATOM   1535 C CB  . VAL A 1 211 ? 33.59459 13.72876  -33.82762 1.000 16.59747 ? 210 VAL A CB  1 
ATOM   1536 C CG1 . VAL A 1 211 ? 34.14476 14.04887  -32.41581 1.000 20.14811 ? 210 VAL A CG1 1 
ATOM   1537 C CG2 . VAL A 1 211 ? 32.48982 12.68401  -33.78449 1.000 21.45661 ? 210 VAL A CG2 1 
ATOM   1538 N N   . PHE A 1 212 ? 31.44565 15.04168  -36.31233 1.000 22.60536 ? 211 PHE A N   1 
ATOM   1539 C CA  . PHE A 1 212 ? 30.91593 14.69787  -37.63124 1.000 19.92699 ? 211 PHE A CA  1 
ATOM   1540 C C   . PHE A 1 212 ? 30.82459 15.88579  -38.58583 1.000 27.13712 ? 211 PHE A C   1 
ATOM   1541 O O   . PHE A 1 212 ? 30.20216 15.75889  -39.63880 1.000 24.37691 ? 211 PHE A O   1 
ATOM   1542 C CB  . PHE A 1 212 ? 29.54035 14.03263  -37.49353 1.000 21.83442 ? 211 PHE A CB  1 
ATOM   1543 C CG  . PHE A 1 212 ? 29.55702 12.80967  -36.63036 1.000 21.90054 ? 211 PHE A CG  1 
ATOM   1544 C CD1 . PHE A 1 212 ? 30.02950 11.60009  -37.12663 1.000 18.25333 ? 211 PHE A CD1 1 
ATOM   1545 C CD2 . PHE A 1 212 ? 29.13167 12.87416  -35.30810 1.000 21.47787 ? 211 PHE A CD2 1 
ATOM   1546 C CE1 . PHE A 1 212 ? 30.08326 10.47938  -36.31941 1.000 20.14164 ? 211 PHE A CE1 1 
ATOM   1547 C CE2 . PHE A 1 212 ? 29.18106 11.75831  -34.49098 1.000 23.71731 ? 211 PHE A CE2 1 
ATOM   1548 C CZ  . PHE A 1 212 ? 29.64615 10.55917  -34.99166 1.000 18.81306 ? 211 PHE A CZ  1 
ATOM   1549 N N   . THR A 1 213 ? 31.42957 17.02558  -38.26065 1.000 28.60418 ? 212 THR A N   1 
ATOM   1550 C CA  . THR A 1 213 ? 31.47935 18.14129  -39.19985 1.000 30.33644 ? 212 THR A CA  1 
ATOM   1551 C C   . THR A 1 213 ? 32.71726 18.03250  -40.08934 1.000 33.45968 ? 212 THR A C   1 
ATOM   1552 O O   . THR A 1 213 ? 33.57162 17.16276  -39.90924 1.000 37.47659 ? 212 THR A O   1 
ATOM   1553 C CB  . THR A 1 213 ? 31.49144 19.47916  -38.46135 1.000 37.50375 ? 212 THR A CB  1 
ATOM   1554 O OG1 . THR A 1 213 ? 32.55035 19.47864  -37.49853 1.000 38.84615 ? 212 THR A OG1 1 
ATOM   1555 C CG2 . THR A 1 213 ? 30.17582 19.72193  -37.75724 1.000 37.07890 ? 212 THR A CG2 1 
ATOM   1556 N N   . TYR A 1 214 ? 32.81141 18.92895  -41.06498 0.256 37.10150 ? 213 TYR A N   1 
ATOM   1557 C CA  . TYR A 1 214 ? 33.99109 18.96216  -41.92646 0.857 38.60495 ? 213 TYR A CA  1 
ATOM   1558 C C   . TYR A 1 214 ? 34.38488 20.39384  -42.27647 0.752 43.41491 ? 213 TYR A C   1 
ATOM   1559 O O   . TYR A 1 214 ? 35.55992 20.68365  -42.50619 0.519 46.31135 ? 213 TYR A O   1 
ATOM   1560 C CB  . TYR A 1 214 ? 33.76208 18.15544  -43.21076 0.870 41.04778 ? 213 TYR A CB  1 
ATOM   1561 C CG  . TYR A 1 214 ? 32.32761 18.07534  -43.69693 0.707 38.96836 ? 213 TYR A CG  1 
ATOM   1562 C CD1 . TYR A 1 214 ? 31.81443 19.01840  -44.58140 0.665 36.92620 ? 213 TYR A CD1 1 
ATOM   1563 C CD2 . TYR A 1 214 ? 31.49997 17.03645  -43.30759 0.675 36.19874 ? 213 TYR A CD2 1 
ATOM   1564 C CE1 . TYR A 1 214 ? 30.50543 18.93756  -45.04086 0.927 36.61003 ? 213 TYR A CE1 1 
ATOM   1565 C CE2 . TYR A 1 214 ? 30.19606 16.95188  -43.76244 0.015 32.27952 ? 213 TYR A CE2 1 
ATOM   1566 C CZ  . TYR A 1 214 ? 29.70024 17.89543  -44.62999 0.454 36.57410 ? 213 TYR A CZ  1 
ATOM   1567 O OH  . TYR A 1 214 ? 28.38916 17.79028  -45.07144 1.000 43.60191 ? 213 TYR A OH  1 
HETATM 1568 O O   . HOH B 2 .   ? -0.09040 3.00886   -29.59020 1.000 37.04187 ? 301 HOH A O   1 
HETATM 1569 O O   . HOH B 2 .   ? 1.54845  8.67320   -12.45414 1.000 39.10182 ? 302 HOH A O   1 
HETATM 1570 O O   . HOH B 2 .   ? 2.68071  1.08245   -23.44832 1.000 40.33668 ? 303 HOH A O   1 
HETATM 1571 O O   . HOH B 2 .   ? 10.43829 0.77506   -25.35436 1.000 44.72484 ? 304 HOH A O   1 
HETATM 1572 O O   . HOH B 2 .   ? 4.95388  21.02288  -14.37878 1.000 56.48924 ? 305 HOH A O   1 
HETATM 1573 O O   . HOH B 2 .   ? 23.64667 4.96650   -17.46136 1.000 32.25960 ? 306 HOH A O   1 
HETATM 1574 O O   . HOH B 2 .   ? 0.90939  15.83946  -14.13441 1.000 38.35371 ? 307 HOH A O   1 
HETATM 1575 O O   . HOH B 2 .   ? 17.53268 -10.31403 -10.76853 1.000 30.95588 ? 308 HOH A O   1 
HETATM 1576 O O   . HOH B 2 .   ? 34.61749 15.05510  -17.39466 1.000 38.09656 ? 309 HOH A O   1 
HETATM 1577 O O   . HOH B 2 .   ? 28.86331 -1.57830  -7.11997  1.000 43.70071 ? 310 HOH A O   1 
HETATM 1578 O O   . HOH B 2 .   ? 26.83042 7.65995   -5.21320  1.000 40.06027 ? 311 HOH A O   1 
HETATM 1579 O O   . HOH B 2 .   ? 27.54229 1.92155   -23.77794 1.000 27.17085 ? 312 HOH A O   1 
HETATM 1580 O O   . HOH B 2 .   ? 9.24440  10.35908  -13.70371 1.000 25.05857 ? 313 HOH A O   1 
HETATM 1581 O O   . HOH B 2 .   ? 28.34033 13.02466  -18.76832 1.000 30.72643 ? 314 HOH A O   1 
HETATM 1582 O O   . HOH B 2 .   ? 28.11877 -0.78427  -20.55564 1.000 37.23264 ? 315 HOH A O   1 
HETATM 1583 O O   . HOH B 2 .   ? 26.54651 15.64355  -12.21096 1.000 34.46504 ? 316 HOH A O   1 
HETATM 1584 O O   . HOH B 2 .   ? 9.32461  24.72810  -32.80319 1.000 43.85819 ? 317 HOH A O   1 
HETATM 1585 O O   . HOH B 2 .   ? 10.46447 13.84239  -13.88173 1.000 43.24943 ? 318 HOH A O   1 
HETATM 1586 O O   . HOH B 2 .   ? 23.03620 -7.48077  -8.07302  1.000 43.09457 ? 319 HOH A O   1 
HETATM 1587 O O   . HOH B 2 .   ? -4.67223 15.66384  -27.90135 1.000 26.85447 ? 320 HOH A O   1 
HETATM 1588 O O   . HOH B 2 .   ? 36.30847 17.25815  -31.78788 1.000 31.46954 ? 321 HOH A O   1 
HETATM 1589 O O   . HOH B 2 .   ? 28.34299 6.63900   -22.34326 1.000 22.71546 ? 322 HOH A O   1 
HETATM 1590 O O   . HOH B 2 .   ? 21.66235 5.13042   1.18400   1.000 29.57508 ? 323 HOH A O   1 
HETATM 1591 O O   . HOH B 2 .   ? 31.90110 20.74645  -31.63900 1.000 46.31072 ? 324 HOH A O   1 
HETATM 1592 O O   . HOH B 2 .   ? 0.86887  17.19969  -21.41397 1.000 23.89219 ? 325 HOH A O   1 
HETATM 1593 O O   . HOH B 2 .   ? 13.95969 10.31250  -19.12547 1.000 19.48301 ? 326 HOH A O   1 
HETATM 1594 O O   . HOH B 2 .   ? 33.91020 14.60745  -39.46507 1.000 22.13490 ? 327 HOH A O   1 
HETATM 1595 O O   . HOH B 2 .   ? 18.92331 0.84046   -37.66853 1.000 27.57533 ? 328 HOH A O   1 
HETATM 1596 O O   . HOH B 2 .   ? 23.02273 -2.28698  -3.72066  1.000 30.33528 ? 329 HOH A O   1 
HETATM 1597 O O   . HOH B 2 .   ? 18.91417 1.46418   -28.38057 1.000 19.92873 ? 330 HOH A O   1 
HETATM 1598 O O   . HOH B 2 .   ? 27.25107 18.57876  -38.03876 1.000 35.07692 ? 331 HOH A O   1 
HETATM 1599 O O   . HOH B 2 .   ? 10.00983 -8.75987  -8.66280  1.000 28.61094 ? 332 HOH A O   1 
HETATM 1600 O O   . HOH B 2 .   ? 26.750   15.921    -35.283   1.000 34.13257 ? 333 HOH A O   1 
HETATM 1601 O O   . HOH B 2 .   ? 25.64129 -6.36796  -18.80462 1.000 37.85571 ? 334 HOH A O   1 
HETATM 1602 O O   . HOH B 2 .   ? 25.35285 -8.48428  -22.84090 1.000 43.30358 ? 335 HOH A O   1 
HETATM 1603 O O   . HOH B 2 .   ? 10.38854 13.58454  -24.92209 1.000 22.06447 ? 336 HOH A O   1 
HETATM 1604 O O   . HOH B 2 .   ? 24.17553 -5.47550  -16.69579 1.000 30.77547 ? 337 HOH A O   1 
HETATM 1605 O O   . HOH B 2 .   ? 21.05467 -8.09631  -15.75921 1.000 46.46134 ? 338 HOH A O   1 
HETATM 1606 O O   . HOH B 2 .   ? 28.54240 16.85469  -30.31017 1.000 40.28699 ? 339 HOH A O   1 
HETATM 1607 O O   . HOH B 2 .   ? 35.24072 17.28195  -19.28659 1.000 30.79269 ? 340 HOH A O   1 
HETATM 1608 O O   . HOH B 2 .   ? 25.26161 7.22185   -18.78715 1.000 22.15922 ? 341 HOH A O   1 
HETATM 1609 O O   . HOH B 2 .   ? 12.25607 17.88258  -22.66356 1.000 42.74724 ? 342 HOH A O   1 
HETATM 1610 O O   . HOH B 2 .   ? 15.71432 -9.22576  -19.66121 1.000 32.45647 ? 343 HOH A O   1 
HETATM 1611 O O   . HOH B 2 .   ? 10.91220 13.95590  -40.57823 1.000 23.95848 ? 344 HOH A O   1 
HETATM 1612 O O   . HOH B 2 .   ? 16.965   19.558    -32.419   1.000 40.45959 ? 345 HOH A O   1 
HETATM 1613 O O   . HOH B 2 .   ? 4.39940  2.34717   -1.58978  1.000 44.82747 ? 346 HOH A O   1 
HETATM 1614 O O   . HOH B 2 .   ? 25.70616 1.23338   -15.97898 1.000 24.14839 ? 347 HOH A O   1 
HETATM 1615 O O   . HOH B 2 .   ? 11.23805 20.41902  -26.25951 1.000 41.61212 ? 348 HOH A O   1 
HETATM 1616 O O   . HOH B 2 .   ? 13.66730 6.21356   2.86517   1.000 26.57709 ? 349 HOH A O   1 
HETATM 1617 O O   . HOH B 2 .   ? 23.44432 5.64470   -4.44789  1.000 22.79156 ? 350 HOH A O   1 
HETATM 1618 O O   . HOH B 2 .   ? 27.525   5.184     -32.036   1.000 17.02590 ? 351 HOH A O   1 
HETATM 1619 O O   . HOH B 2 .   ? 18.47663 1.17308   -31.04058 1.000 26.00381 ? 352 HOH A O   1 
HETATM 1620 O O   . HOH B 2 .   ? 23.92867 17.11455  -26.95098 1.000 30.46189 ? 353 HOH A O   1 
HETATM 1621 O O   . HOH B 2 .   ? 26.20389 -2.52086  -3.79527  1.000 43.86983 ? 354 HOH A O   1 
HETATM 1622 O O   . HOH B 2 .   ? 2.06665  -0.01485  -14.98071 1.000 44.21686 ? 355 HOH A O   1 
HETATM 1623 O O   . HOH B 2 .   ? 17.04883 -9.52382  -8.31209  1.000 30.57397 ? 356 HOH A O   1 
HETATM 1624 O O   . HOH B 2 .   ? 35.069   7.022     -23.569   1.000 43.53801 ? 357 HOH A O   1 
HETATM 1625 O O   . HOH B 2 .   ? 27.36156 12.66923  -31.62181 1.000 18.89784 ? 358 HOH A O   1 
HETATM 1626 O O   . HOH B 2 .   ? 38.96317 15.19485  -23.07963 1.000 44.41396 ? 359 HOH A O   1 
HETATM 1627 O O   . HOH B 2 .   ? 32.34734 20.31201  -19.58974 1.000 40.14557 ? 360 HOH A O   1 
HETATM 1628 O O   . HOH B 2 .   ? 13.93137 -8.70837  -2.13464  1.000 36.96418 ? 361 HOH A O   1 
HETATM 1629 O O   . HOH B 2 .   ? 27.021   3.752     -29.705   1.000 29.69207 ? 362 HOH A O   1 
HETATM 1630 O O   . HOH B 2 .   ? 28.79279 1.19758   -16.83003 1.000 38.45174 ? 363 HOH A O   1 
HETATM 1631 O O   . HOH B 2 .   ? 7.80347  13.12776  -13.51119 1.000 32.81806 ? 364 HOH A O   1 
HETATM 1632 O O   . HOH B 2 .   ? 9.36410  -1.46234  -4.80576  1.000 23.19314 ? 365 HOH A O   1 
HETATM 1633 O O   . HOH B 2 .   ? 14.20524 -6.07391  -24.37679 1.000 33.22141 ? 366 HOH A O   1 
HETATM 1634 O O   . HOH B 2 .   ? 26.59737 -2.66108  -11.33720 1.000 26.08044 ? 367 HOH A O   1 
HETATM 1635 O O   . HOH B 2 .   ? 7.53990  0.30485   -6.15234  1.000 30.13483 ? 368 HOH A O   1 
HETATM 1636 O O   . HOH B 2 .   ? 24.00018 -7.14727  -21.02338 1.000 36.54390 ? 369 HOH A O   1 
HETATM 1637 O O   . HOH B 2 .   ? 13.36807 -12.03966 -13.27018 1.000 30.45724 ? 370 HOH A O   1 
HETATM 1638 O O   . HOH B 2 .   ? 1.61833  19.67869  -31.04606 1.000 43.12738 ? 371 HOH A O   1 
HETATM 1639 O O   . HOH B 2 .   ? 13.57679 19.69471  -27.90382 1.000 37.40311 ? 372 HOH A O   1 
HETATM 1640 O O   . HOH B 2 .   ? 16.43708 20.08174  -6.65672  1.000 47.01201 ? 373 HOH A O   1 
HETATM 1641 O O   . HOH B 2 .   ? 1.56347  18.76635  -28.40597 1.000 36.69784 ? 374 HOH A O   1 
HETATM 1642 O O   . HOH B 2 .   ? 3.340    18.048    -38.293   1.000 38.10453 ? 375 HOH A O   1 
HETATM 1643 O O   . HOH B 2 .   ? 24.67231 14.90309  -21.37704 1.000 26.19621 ? 376 HOH A O   1 
HETATM 1644 O O   . HOH B 2 .   ? 23.16942 -0.65821  -27.06752 1.000 24.62105 ? 377 HOH A O   1 
HETATM 1645 O O   . HOH B 2 .   ? 6.40561  -6.27202  -16.31591 1.000 37.29550 ? 378 HOH A O   1 
HETATM 1646 O O   . HOH B 2 .   ? 8.04786  -7.59448  -14.58594 1.000 27.75000 ? 379 HOH A O   1 
HETATM 1647 O O   . HOH B 2 .   ? 11.55060 5.08497   1.93817   1.000 29.51759 ? 380 HOH A O   1 
HETATM 1648 O O   . HOH B 2 .   ? 32.63634 17.38100  -11.47929 1.000 44.23108 ? 381 HOH A O   1 
HETATM 1649 O O   . HOH B 2 .   ? 27.646   18.215    -42.350   1.000 36.69971 ? 382 HOH A O   1 
HETATM 1650 O O   . HOH B 2 .   ? 7.019    16.383    -39.836   1.000 34.34100 ? 383 HOH A O   1 
HETATM 1651 O O   . HOH B 2 .   ? 22.06919 -10.13420 -10.46514 1.000 52.17607 ? 384 HOH A O   1 
HETATM 1652 O O   . HOH B 2 .   ? 25.79469 5.87457   -21.29665 1.000 22.42359 ? 385 HOH A O   1 
HETATM 1653 O O   . HOH B 2 .   ? 14.71001 4.43727   -41.35109 1.000 23.56474 ? 386 HOH A O   1 
HETATM 1654 O O   . HOH B 2 .   ? 9.74177  4.78732   -29.56913 1.000 33.57669 ? 387 HOH A O   1 
HETATM 1655 O O   . HOH B 2 .   ? 4.65134  -0.04276  -31.19208 1.000 33.18500 ? 388 HOH A O   1 
HETATM 1656 O O   . HOH B 2 .   ? 1.74656  9.23524   -15.39687 1.000 29.88152 ? 389 HOH A O   1 
HETATM 1657 O O   . HOH B 2 .   ? -5.45338 8.71166   -22.34951 1.000 39.44749 ? 390 HOH A O   1 
HETATM 1658 O O   . HOH B 2 .   ? 8.87013  0.44185   -41.71469 1.000 38.56963 ? 391 HOH A O   1 
HETATM 1659 O O   . HOH B 2 .   ? 30.84333 18.83689  -23.36560 1.000 37.33169 ? 392 HOH A O   1 
HETATM 1660 O O   . HOH B 2 .   ? 0.950    19.286    -37.819   1.000 43.71698 ? 393 HOH A O   1 
HETATM 1661 O O   . HOH B 2 .   ? 17.55106 12.40766  -3.11618  1.000 35.49514 ? 394 HOH A O   1 
HETATM 1662 O O   . HOH B 2 .   ? 21.465   -2.540    -1.638    1.000 34.64969 ? 395 HOH A O   1 
HETATM 1663 O O   . HOH B 2 .   ? 24.60101 -2.71613  -27.16128 1.000 37.89070 ? 396 HOH A O   1 
HETATM 1664 O O   . HOH B 2 .   ? 15.729   1.605     0.737     1.000 27.52970 ? 397 HOH A O   1 
HETATM 1665 O O   . HOH B 2 .   ? 27.48291 18.81565  -7.82612  1.000 41.76645 ? 398 HOH A O   1 
HETATM 1666 O O   . HOH B 2 .   ? 17.55583 -0.92061  -2.40616  1.000 24.88103 ? 399 HOH A O   1 
HETATM 1667 O O   . HOH B 2 .   ? 27.18072 19.64285  -18.20876 1.000 26.40258 ? 400 HOH A O   1 
HETATM 1668 O O   . HOH B 2 .   ? 29.34072 14.66406  -32.04772 1.000 28.45091 ? 401 HOH A O   1 
HETATM 1669 O O   . HOH B 2 .   ? 0.56032  3.23297   -27.04051 1.000 39.26601 ? 402 HOH A O   1 
HETATM 1670 O O   . HOH B 2 .   ? -5.15994 15.41079  -18.56791 1.000 41.21031 ? 403 HOH A O   1 
HETATM 1671 O O   . HOH B 2 .   ? 31.28996 18.62769  -26.28310 1.000 26.60989 ? 404 HOH A O   1 
HETATM 1672 O O   . HOH B 2 .   ? 16.94246 -5.73040  -25.38111 1.000 37.70132 ? 405 HOH A O   1 
HETATM 1673 O O   . HOH B 2 .   ? 19.82936 12.14793  -2.84998  1.000 39.29869 ? 406 HOH A O   1 
HETATM 1674 O O   . HOH B 2 .   ? 26.909   -9.487    -26.215   1.000 42.36983 ? 407 HOH A O   1 
HETATM 1675 O O   . HOH B 2 .   ? 25.75356 14.15017  -8.60975  1.000 33.61651 ? 408 HOH A O   1 
HETATM 1676 O O   . HOH B 2 .   ? 5.86310  -1.89633  -7.53150  1.000 38.14773 ? 409 HOH A O   1 
HETATM 1677 O O   . HOH B 2 .   ? 21.51032 2.60801   -26.93248 1.000 18.63105 ? 410 HOH A O   1 
HETATM 1678 O O   . HOH B 2 .   ? 32.24329 2.13162   -16.59060 1.000 49.26287 ? 411 HOH A O   1 
HETATM 1679 O O   . HOH B 2 .   ? 27.70795 13.47518  -20.98813 1.000 33.81339 ? 412 HOH A O   1 
HETATM 1680 O O   . HOH B 2 .   ? 8.11644  5.04627   -0.10970  1.000 29.93187 ? 413 HOH A O   1 
HETATM 1681 O O   . HOH B 2 .   ? 26.63384 -0.55899  -3.16570  1.000 40.34483 ? 414 HOH A O   1 
HETATM 1682 O O   . HOH B 2 .   ? 29.32092 1.14612   -3.18199  1.000 37.95115 ? 415 HOH A O   1 
HETATM 1683 O O   . HOH B 2 .   ? 6.34237  -8.76099  -16.82901 1.000 35.16856 ? 416 HOH A O   1 
HETATM 1684 O O   . HOH B 2 .   ? 2.81734  1.48510   -37.77364 1.000 40.72571 ? 417 HOH A O   1 
HETATM 1685 O O   . HOH B 2 .   ? 19.483   0.425     0.978     1.000 35.01345 ? 418 HOH A O   1 
HETATM 1686 O O   . HOH B 2 .   ? 22.50925 12.91483  -2.85578  1.000 51.76056 ? 419 HOH A O   1 
HETATM 1687 O O   . HOH B 2 .   ? 0.43577  0.87703   -43.70783 1.000 44.59056 ? 420 HOH A O   1 
HETATM 1688 O O   . HOH B 2 .   ? 18.50182 -3.02915  -27.95379 1.000 40.11692 ? 421 HOH A O   1 
HETATM 1689 O O   . HOH B 2 .   ? 25.87250 3.79927   -33.62850 0.50  25.77036 ? 422 HOH A O   1 
HETATM 1690 O O   . HOH B 2 .   ? 6.87963  -0.79017  -30.15276 1.000 43.30203 ? 423 HOH A O   1 
HETATM 1691 O O   . HOH B 2 .   ? 8.39681  23.63705  -24.78071 1.000 48.24172 ? 424 HOH A O   1 
HETATM 1692 O O   . HOH B 2 .   ? 24.25433 1.62731   -27.46343 1.000 22.45480 ? 425 HOH A O   1 
HETATM 1693 O O   . HOH B 2 .   ? 20.66293 24.92252  -13.90978 1.000 42.12682 ? 426 HOH A O   1 
HETATM 1694 O O   . HOH B 2 .   ? 22.85192 -6.87497  -5.34495  1.000 37.12311 ? 427 HOH A O   1 
HETATM 1695 O O   . HOH B 2 .   ? 10.77516 -1.68705  -25.87951 1.000 45.45004 ? 428 HOH A O   1 
HETATM 1696 O O   . HOH B 2 .   ? 10.81174 16.04999  -21.90863 1.000 26.85943 ? 429 HOH A O   1 
HETATM 1697 O O   . HOH B 2 .   ? 8.18554  19.30529  -37.76992 1.000 29.09725 ? 430 HOH A O   1 
HETATM 1698 O O   . HOH B 2 .   ? 15.232   19.192    -34.336   1.000 43.00253 ? 431 HOH A O   1 
HETATM 1699 O O   . HOH B 2 .   ? 8.74203  -4.13641  -4.65576  1.000 38.67343 ? 432 HOH A O   1 
HETATM 1700 O O   . HOH B 2 .   ? 30.52249 2.09169   -12.76152 1.000 44.01839 ? 433 HOH A O   1 
HETATM 1701 O O   . HOH B 2 .   ? 14.84208 17.79617  -11.72743 1.000 35.64897 ? 434 HOH A O   1 
HETATM 1702 O O   . HOH B 2 .   ? 11.67550 1.85258   -40.71699 1.000 21.17028 ? 435 HOH A O   1 
HETATM 1703 O O   . HOH B 2 .   ? 7.082    -8.041    -21.176   1.000 40.49204 ? 436 HOH A O   1 
HETATM 1704 O O   . HOH B 2 .   ? 10.971   9.441     1.403     1.000 52.71032 ? 437 HOH A O   1 
HETATM 1705 O O   . HOH B 2 .   ? 7.85547  17.72980  -20.40974 1.000 25.57965 ? 438 HOH A O   1 
HETATM 1706 O O   . HOH B 2 .   ? 18.14978 14.87064  -23.68735 1.000 22.91114 ? 439 HOH A O   1 
HETATM 1707 O O   . HOH B 2 .   ? 17.82656 12.87989  -25.67753 1.000 17.13404 ? 440 HOH A O   1 
HETATM 1708 O O   . HOH B 2 .   ? 24.504   4.981     4.102     1.000 44.18060 ? 441 HOH A O   1 
HETATM 1709 O O   . HOH B 2 .   ? -2.78171 14.24951  -15.72855 1.000 44.44944 ? 442 HOH A O   1 
HETATM 1710 O O   . HOH B 2 .   ? 19.68953 0.82673   -41.34045 1.000 49.33104 ? 443 HOH A O   1 
HETATM 1711 O O   . HOH B 2 .   ? 35.18715 20.17036  -31.04063 1.000 55.58353 ? 444 HOH A O   1 
HETATM 1712 O O   . HOH B 2 .   ? 19.96227 7.35245   0.05648   1.000 37.61852 ? 445 HOH A O   1 
HETATM 1713 O O   . HOH B 2 .   ? 13.99657 16.59866  -14.55849 1.000 59.88232 ? 446 HOH A O   1 
HETATM 1714 O O   . HOH B 2 .   ? 24.01206 0.20051   -2.62239  1.000 45.97431 ? 447 HOH A O   1 
HETATM 1715 O O   . HOH B 2 .   ? 15.72032 17.41134  -14.05469 1.000 50.69129 ? 448 HOH A O   1 
HETATM 1716 O O   . HOH B 2 .   ? 27.984   -0.968    -29.761   1.000 47.60706 ? 449 HOH A O   1 
HETATM 1717 O O   . HOH B 2 .   ? 26.81962 -2.80862  -13.91228 1.000 35.49486 ? 450 HOH A O   1 
HETATM 1718 O O   . HOH B 2 .   ? 33.12756 20.74122  -26.57660 1.000 51.73691 ? 451 HOH A O   1 
HETATM 1719 O O   . HOH B 2 .   ? 30.07801 4.70199   -26.32297 1.000 26.98618 ? 452 HOH A O   1 
HETATM 1720 O O   . HOH B 2 .   ? 7.55602  -9.02226  -12.29392 1.000 30.84515 ? 453 HOH A O   1 
HETATM 1721 O O   . HOH B 2 .   ? 9.69498  -10.35484 -11.21268 1.000 39.39144 ? 454 HOH A O   1 
HETATM 1722 O O   . HOH B 2 .   ? 19.145   3.949     -40.911   1.000 36.20176 ? 455 HOH A O   1 
HETATM 1723 O O   . HOH B 2 .   ? 29.11902 0.06506   -22.82293 1.000 39.63739 ? 456 HOH A O   1 
HETATM 1724 O O   . HOH B 2 .   ? 27.91682 15.94886  -8.43298  1.000 44.39278 ? 457 HOH A O   1 
HETATM 1725 O O   . HOH B 2 .   ? 0.16246  7.05785   -16.34789 1.000 46.03733 ? 458 HOH A O   1 
HETATM 1726 O O   . HOH B 2 .   ? 7.966    26.998    -35.100   1.000 47.56877 ? 459 HOH A O   1 
HETATM 1727 O O   . HOH B 2 .   ? 26.85603 1.56178   -26.38508 1.000 28.85663 ? 460 HOH A O   1 
HETATM 1728 O O   . HOH B 2 .   ? 40.33971 10.46862  -22.41546 1.000 41.26836 ? 461 HOH A O   1 
HETATM 1729 O O   . HOH B 2 .   ? 17.17132 -0.69731  -27.50886 1.000 24.68160 ? 462 HOH A O   1 
HETATM 1730 O O   . HOH B 2 .   ? 13.55801 -13.27784 -15.83555 1.000 44.56526 ? 463 HOH A O   1 
HETATM 1731 O O   . HOH B 2 .   ? 2.10793  1.04071   -12.38432 1.000 47.96096 ? 464 HOH A O   1 
HETATM 1732 O O   . HOH B 2 .   ? 24.699   17.157    -35.307   1.000 35.86779 ? 465 HOH A O   1 
HETATM 1733 O O   . HOH B 2 .   ? 12.48382 -0.32697  -28.07292 1.000 34.82423 ? 466 HOH A O   1 
HETATM 1734 O O   . HOH B 2 .   ? 29.38588 4.18255   -23.65300 1.000 25.26106 ? 467 HOH A O   1 
HETATM 1735 O O   . HOH B 2 .   ? 16.91141 4.75507   -42.69553 1.000 36.89831 ? 468 HOH A O   1 
HETATM 1736 O O   . HOH B 2 .   ? 12.38673 15.92636  -15.80446 1.000 45.11483 ? 469 HOH A O   1 
HETATM 1737 O O   . HOH B 2 .   ? 11.30048 21.05748  -9.83043  1.000 52.81419 ? 470 HOH A O   1 
HETATM 1738 O O   . HOH B 2 .   ? 26.431   6.486     5.315     1.000 51.38120 ? 471 HOH A O   1 
HETATM 1739 O O   . HOH B 2 .   ? 11.625   26.211    -38.754   1.000 34.82630 ? 472 HOH A O   1 
HETATM 1740 O O   . HOH B 2 .   ? 21.03927 -0.26918  -28.95815 1.000 26.13454 ? 473 HOH A O   1 
HETATM 1741 O O   . HOH B 2 .   ? 9.24599  6.78141   2.11681   1.000 42.42985 ? 474 HOH A O   1 
HETATM 1742 O O   . HOH B 2 .   ? 28.50759 2.93619   -27.88271 1.000 24.75308 ? 475 HOH A O   1 
HETATM 1743 O O   . HOH B 2 .   ? -0.32227 13.88884  -14.70466 1.000 43.14907 ? 476 HOH A O   1 
HETATM 1744 O O   . HOH B 2 .   ? 14.88638 17.98111  -16.35265 1.000 47.42547 ? 477 HOH A O   1 
HETATM 1745 O O   . HOH B 2 .   ? 24.477   18.239    -46.635   1.000 34.69728 ? 478 HOH A O   1 
HETATM 1746 O O   . HOH B 2 .   ? 20.07622 -1.10365  -31.69029 1.000 36.90360 ? 479 HOH A O   1 
HETATM 1747 O O   . HOH B 2 .   ? 39.38145 12.79259  -24.19827 1.000 41.18658 ? 480 HOH A O   1 
HETATM 1748 O O   . HOH B 2 .   ? 10.87381 16.16291  -41.66856 1.000 42.33307 ? 481 HOH A O   1 
HETATM 1749 O O   . HOH B 2 .   ? 17.02204 -4.43355  -27.98365 1.000 40.64321 ? 482 HOH A O   1 
HETATM 1750 O O   . HOH B 2 .   ? 25.87250 13.87576  -33.62850 0.50  28.06384 ? 483 HOH A O   1 
HETATM 1751 O O   . HOH B 2 .   ? 16.02949 -0.29848  -30.87097 1.000 31.82974 ? 484 HOH A O   1 
HETATM 1752 O O   . HOH B 2 .   ? 20.93168 1.20278   -39.79227 1.000 48.53064 ? 485 HOH A O   1 
HETATM 1753 O O   . HOH B 2 .   ? 25.61882 19.94617  -38.83298 1.000 47.53365 ? 486 HOH A O   1 
HETATM 1754 O O   . HOH B 2 .   ? 21.17383 -0.98404  -33.91999 1.000 36.25581 ? 487 HOH A O   1 
HETATM 1755 O O   . HOH B 2 .   ? 26.44273 -5.09226  -15.24854 1.000 35.74087 ? 488 HOH A O   1 
HETATM 1756 O O   . HOH B 2 .   ? 9.82574  22.21008  -9.58062  1.000 58.81538 ? 489 HOH A O   1 
HETATM 1757 O O   . HOH B 2 .   ? 28.42425 19.50270  -22.44209 1.000 35.04511 ? 490 HOH A O   1 
HETATM 1758 O O   . HOH B 2 .   ? 38.67144 13.71907  -20.67551 1.000 47.21800 ? 491 HOH A O   1 
HETATM 1759 O O   . HOH B 2 .   ? 19.51236 -8.83513  -6.66096  1.000 40.02775 ? 492 HOH A O   1 
HETATM 1760 O O   . HOH B 2 .   ? 14.76060 -1.02161  -28.47646 1.000 34.57599 ? 493 HOH A O   1 
HETATM 1761 O O   . HOH B 2 .   ? 27.02492 15.53270  -20.37863 1.000 28.83811 ? 494 HOH A O   1 
HETATM 1762 O O   . HOH B 2 .   ? 5.39075  1.19261   0.45320   1.000 42.53321 ? 495 HOH A O   1 
HETATM 1763 O O   . HOH B 2 .   ? 27.25797 -1.16525  -26.97987 1.000 37.56104 ? 496 HOH A O   1 
HETATM 1764 O O   . HOH B 2 .   ? 29.565   0.506     -29.318   1.000 47.59002 ? 497 HOH A O   1 
# 
