data_9F39
# 
_entry.id   9F39 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9F39         pdb_00009f39 10.2210/pdb9f39/pdb 
WWPDB D_1292138110 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2025-01-29 
2 'Structure model' 1 1 2025-02-26 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9F39 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              rolf.hilgenfeld@uni-luebeck.de 
_pdbx_contact_author.name_first         Rolf 
_pdbx_contact_author.name_last          Hilgenfeld 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-8850-2977 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'El kilani, H.'  1 0000-0003-4084-3582 
'Hilgenfeld, R.' 2 0000-0001-8850-2977 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Med.Chem. 
_citation.journal_id_ASTM           JMCMAR 
_citation.journal_id_CSD            0151 
_citation.journal_id_ISSN           0022-2623 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            68 
_citation.language                  ? 
_citation.page_first                2920 
_citation.page_last                 2941 
_citation.title                     
'Structure-Based Optimization of Pyridone alpha-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.jmedchem.4c02172 
_citation.pdbx_database_id_PubMed   39817813 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Akula, R.K.'    1  ? 
primary 'El Kilani, H.'  2  ? 
primary 'Metzen, A.'     3  ? 
primary 'Roske, J.'      4  ? 
primary 'Zhang, K.'      5  ? 
primary 'Gohl, M.'       6  ? 
primary 'Arisetti, N.'   7  ? 
primary 'Marsh, G.P.'    8  ? 
primary 'Maple, H.J.'    9  ? 
primary 'Cooper, M.S.'   10 ? 
primary 'Karadogan, B.'  11 ? 
primary 'Jochmans, D.'   12 ? 
primary 'Neyts, J.'      13 ? 
primary 'Rox, K.'        14 ? 
primary 'Hilgenfeld, R.' 15 ? 
primary 'Bronstrup, M.'  16 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5' 33697.418 1  3.4.22.69 ? ? ? 
2 non-polymer syn 
;(2R,3R)-3-[[(2S)-3-cyclopropyl-2-[3-(2-methylpropanoylamino)-2-oxidanylidene-pyridin-1-yl]propanoyl]amino]-N-methyl-2-oxidanyl-4-[(3S)-2-oxidanylidenepyrrolidin-3-yl]butanamide
;
489.565   1  ?         ? ? ? 
3 water       nat water 18.015    24 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTF
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTF
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;(2R,3R)-3-[[(2S)-3-cyclopropyl-2-[3-(2-methylpropanoylamino)-2-oxidanylidene-pyridin-1-yl]propanoyl]amino]-N-methyl-2-oxidanyl-4-[(3S)-2-oxidanylidenepyrrolidin-3-yl]butanamide
;
A1H9Y 
3 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   305 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1H9Y non-polymer         . 
;(2R,3R)-3-[[(2S)-3-cyclopropyl-2-[3-(2-methylpropanoylamino)-2-oxidanylidene-pyridin-1-yl]propanoyl]amino]-N-methyl-2-oxidanyl-4-[(3S)-2-oxidanylidenepyrrolidin-3-yl]butanamide
;
? 'C24 H35 N5 O6'  489.565 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 305 305 PHE PHE A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1H9Y 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1H9Y 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1H9Y 1  401 401 A1H9Y LIG A . 
C 3 HOH   1  501 2   HOH   HOH A . 
C 3 HOH   2  502 8   HOH   HOH A . 
C 3 HOH   3  503 10  HOH   HOH A . 
C 3 HOH   4  504 24  HOH   HOH A . 
C 3 HOH   5  505 19  HOH   HOH A . 
C 3 HOH   6  506 5   HOH   HOH A . 
C 3 HOH   7  507 20  HOH   HOH A . 
C 3 HOH   8  508 15  HOH   HOH A . 
C 3 HOH   9  509 6   HOH   HOH A . 
C 3 HOH   10 510 30  HOH   HOH A . 
C 3 HOH   11 511 11  HOH   HOH A . 
C 3 HOH   12 512 28  HOH   HOH A . 
C 3 HOH   13 513 3   HOH   HOH A . 
C 3 HOH   14 514 25  HOH   HOH A . 
C 3 HOH   15 515 18  HOH   HOH A . 
C 3 HOH   16 516 26  HOH   HOH A . 
C 3 HOH   17 517 4   HOH   HOH A . 
C 3 HOH   18 518 1   HOH   HOH A . 
C 3 HOH   19 519 13  HOH   HOH A . 
C 3 HOH   20 520 22  HOH   HOH A . 
C 3 HOH   21 521 33  HOH   HOH A . 
C 3 HOH   22 522 31  HOH   HOH A . 
C 3 HOH   23 523 29  HOH   HOH A . 
C 3 HOH   24 524 32  HOH   HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0419 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP  ? ? ? .        4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   102.445 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9F39 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     113.702 
_cell.length_a_esd                 ? 
_cell.length_b                     53.197 
_cell.length_b_esd                 ? 
_cell.length_c                     44.856 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9F39 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9F39 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.97 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          37.42 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M MMT pH 9.0, 25% w/v PEG 1500' 
_exptl_crystal_grow.pdbx_pH_range   9.0 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-06-08 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0332 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PETRA III, DESY BEAMLINE P11' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0332 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   P11 
_diffrn_source.pdbx_synchrotron_site       'PETRA III, DESY' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9F39 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.45 
_reflns.d_resolution_low                               47.97 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     9623 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.34 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.993 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.45 
_reflns_shell.d_res_low                                     2.538 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             976 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.559 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            7.946 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            0.449 
_refine.aniso_B[2][2]                            -2.431 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            -5.206 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               52.056 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.955 
_refine.correlation_coeff_Fo_to_Fc_free          0.909 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9F39 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.450 
_refine.ls_d_res_low                             47.97 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     9623 
_refine.ls_number_reflns_R_free                  472 
_refine.ls_number_reflns_R_work                  9151 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.385 
_refine.ls_percent_reflns_R_free                 4.905 
_refine.ls_R_factor_all                          0.220 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.3052 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2156 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  0.393 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             24.667 
_refine.overall_SU_ML                            0.477 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        2358 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         35 
_refine_hist.number_atoms_solvent             24 
_refine_hist.number_atoms_total               2417 
_refine_hist.d_res_high                       2.450 
_refine_hist.d_res_low                        47.97 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.004  0.011  2449 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  2271 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.102  1.657  3329 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 0.385  1.575  5217 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 7.819  5.000  304  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 9.097  5.000  14   ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 2.878  5.000  2    ? r_dihedral_angle_other_2_deg   ? ? 
'X-RAY DIFFRACTION' ? 18.007 10.000 386  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 1.063  10.000 1    ? r_dihedral_angle_other_3_deg   ? ? 
'X-RAY DIFFRACTION' ? 15.024 10.000 109  ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.048  0.200  376  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.004  0.020  2904 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  582  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.229  0.200  537  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.211  0.200  2345 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.188  0.200  1222 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.084  0.200  1353 ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.170  0.200  89   ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.037  0.200  2    ? r_symmetry_xyhbond_nbd_other   ? ? 
'X-RAY DIFFRACTION' ? 0.183  0.200  41   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.194  0.200  125  ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.170  0.200  18   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 3.268  5.094  1219 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.264  5.095  1219 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.198  9.136  1522 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.199  9.140  1523 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 3.489  5.472  1230 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.488  5.472  1231 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.933  9.914  1804 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.932  9.912  1805 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 9.013  53.917 2744 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 9.012  53.915 2745 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.450  2.514  . . 48 681 99.5902  . . . . 0.396 . . . . . . . . . . . 0.408 
'X-RAY DIFFRACTION' 2.514  2.582  . . 26 656 98.4127  . . . . 0.370 . . . . . . . . . . . 0.522 
'X-RAY DIFFRACTION' 2.582  2.657  . . 34 639 99.2625  . . . . 0.379 . . . . . . . . . . . 0.441 
'X-RAY DIFFRACTION' 2.657  2.738  . . 30 610 98.6133  . . . . 0.356 . . . . . . . . . . . 0.314 
'X-RAY DIFFRACTION' 2.738  2.828  . . 32 619 99.3893  . . . . 0.334 . . . . . . . . . . . 0.352 
'X-RAY DIFFRACTION' 2.828  2.927  . . 26 572 99.8331  . . . . 0.311 . . . . . . . . . . . 0.403 
'X-RAY DIFFRACTION' 2.927  3.037  . . 32 567 98.8449  . . . . 0.269 . . . . . . . . . . . 0.454 
'X-RAY DIFFRACTION' 3.037  3.160  . . 37 533 98.9583  . . . . 0.239 . . . . . . . . . . . 0.334 
'X-RAY DIFFRACTION' 3.160  3.300  . . 20 500 92.5267  . . . . 0.232 . . . . . . . . . . . 0.393 
'X-RAY DIFFRACTION' 3.300  3.460  . . 23 494 99.6146  . . . . 0.213 . . . . . . . . . . . 0.321 
'X-RAY DIFFRACTION' 3.460  3.647  . . 27 476 99.8016  . . . . 0.194 . . . . . . . . . . . 0.240 
'X-RAY DIFFRACTION' 3.647  3.866  . . 19 451 99.3658  . . . . 0.174 . . . . . . . . . . . 0.299 
'X-RAY DIFFRACTION' 3.866  4.131  . . 22 437 99.7826  . . . . 0.167 . . . . . . . . . . . 0.309 
'X-RAY DIFFRACTION' 4.131  4.460  . . 15 397 99.2771  . . . . 0.135 . . . . . . . . . . . 0.181 
'X-RAY DIFFRACTION' 4.460  4.881  . . 22 361 98.9664  . . . . 0.149 . . . . . . . . . . . 0.264 
'X-RAY DIFFRACTION' 4.881  5.450  . . 13 328 97.9885  . . . . 0.155 . . . . . . . . . . . 0.218 
'X-RAY DIFFRACTION' 5.450  6.280  . . 19 265 89.3082  . . . . 0.181 . . . . . . . . . . . 0.351 
'X-RAY DIFFRACTION' 6.280  7.659  . . 12 241 95.1128  . . . . 0.157 . . . . . . . . . . . 0.285 
'X-RAY DIFFRACTION' 7.659  10.696 . . 11 197 100.0000 . . . . 0.127 . . . . . . . . . . . 0.168 
'X-RAY DIFFRACTION' 10.696 47.97  . . 4  127 99.2424  . . . . 0.182 . . . . . . . . . . . 0.161 
# 
_struct.entry_id                     9F39 
_struct.title                        'Crystal structure of SARS-CoV-2 Mpro in complex with RK-54' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9F39 
_struct_keywords.text            'Complex, ANTIVIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'ANTIVIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTF
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9F39 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 305 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3568 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       305 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3100  ? 
1 MORE         -15   ? 
1 'SSA (A^2)'  24750 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'native gel electrophoresis' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -9.6665728496 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 43.8020331188 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? PHE A 66  ? SER A 62  PHE A 66  5 ? 5  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? GLY A 258 ? THR A 243 GLY A 258 1 ? 16 
HELX_P HELX_P9  AA9 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P10 AB1 THR A 292 ? CYS A 300 ? THR A 292 CYS A 300 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        none 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           A1H9Y 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C13 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            A1H9Y 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.796 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      A1H9Y 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       A1H9Y 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C13 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        A1H9Y 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 LEU A 67  ? ALA A 70  ? LEU A 67  ALA A 70  
AA1 3 MET A 17  ? THR A 21  ? MET A 17  THR A 21  
AA1 4 THR A 26  ? LEU A 32  ? THR A 26  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? LYS A 90  ? VAL A 86  LYS A 90  
AA1 7 SER A 81  ? GLN A 83  ? SER A 81  GLN A 83  
AA2 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA2 2 CYS A 156 ? LEU A 167 ? CYS A 156 LEU A 167 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA3 2 CYS A 156 ? LEU A 167 ? CYS A 156 LEU A 167 
AA3 3 VAL A 171 ? THR A 175 ? VAL A 171 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 18  ? N VAL A 18  O GLY A 29  ? O GLY A 29  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O VAL A 86  ? O VAL A 86  N GLN A 83  ? N GLN A 83  
AA2 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N VAL A 114 ? N VAL A 114 O TYR A 126 ? O TYR A 126 
AA3 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA3 2 3 N LEU A 167 ? N LEU A 167 O VAL A 171 ? O VAL A 171 
# 
_pdbx_entry_details.entry_id                   9F39 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 PHE A 8   ? ? -47.32  159.56  
2  1 ASP A 33  ? ? 57.36   -132.29 
3  1 ASP A 34  ? ? -103.04 42.34   
4  1 ASN A 51  ? ? -168.64 77.98   
5  1 SER A 81  ? ? -170.62 140.35  
6  1 ASN A 84  ? ? 48.01   -110.67 
7  1 TYR A 154 ? ? 65.25   -81.33  
8  1 HIS A 164 ? ? -135.87 -49.71  
9  1 ASN A 238 ? ? 51.56   70.15   
10 1 CYS A 300 ? ? -108.09 40.36   
11 1 SER A 301 ? ? -164.21 -29.42  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1H9Y N1   N N N 1   
A1H9Y N3   N N N 2   
A1H9Y C4   C N N 3   
A1H9Y C5   C N N 4   
A1H9Y C6   C N S 5   
A1H9Y C7   C N N 6   
A1H9Y C8   C N R 7   
A1H9Y C10  C N N 8   
A1H9Y C13  C N R 9   
A1H9Y C15  C N N 10  
A1H9Y C17  C N N 11  
A1H9Y C20  C N N 12  
A1H9Y C21  C N N 13  
A1H9Y C22  C N N 14  
A1H9Y C24  C N N 15  
A1H9Y C1   C N N 16  
A1H9Y C2   C N N 17  
A1H9Y C3   C N N 18  
A1H9Y N2   N N N 19  
A1H9Y C9   C N N 20  
A1H9Y C11  C N N 21  
A1H9Y C12  C N N 22  
A1H9Y O1   O N N 23  
A1H9Y O2   O N N 24  
A1H9Y C14  C N N 25  
A1H9Y C16  C N S 26  
A1H9Y C18  C N N 27  
A1H9Y N4   N N N 28  
A1H9Y C19  C N N 29  
A1H9Y O3   O N N 30  
A1H9Y C23  C N N 31  
A1H9Y N5   N N N 32  
A1H9Y O4   O N N 33  
A1H9Y O5   O N N 34  
A1H9Y O6   O N N 35  
A1H9Y H6   H N N 36  
A1H9Y H3   H N N 37  
A1H9Y H4   H N N 38  
A1H9Y H7   H N N 39  
A1H9Y H10  H N N 40  
A1H9Y H15  H N N 41  
A1H9Y H19  H N N 42  
A1H9Y H20  H N N 43  
A1H9Y H24  H N N 44  
A1H9Y H26  H N N 45  
A1H9Y H25  H N N 46  
A1H9Y H27  H N N 47  
A1H9Y H34  H N N 48  
A1H9Y H33  H N N 49  
A1H9Y H32  H N N 50  
A1H9Y H1   H N N 51  
A1H9Y H2   H N N 52  
A1H9Y H5   H N N 53  
A1H9Y H9   H N N 54  
A1H9Y H8   H N N 55  
A1H9Y H11  H N N 56  
A1H9Y H12  H N N 57  
A1H9Y H13  H N N 58  
A1H9Y H14  H N N 59  
A1H9Y H16  H N N 60  
A1H9Y H17  H N N 61  
A1H9Y H18  H N N 62  
A1H9Y H21  H N N 63  
A1H9Y H22  H N N 64  
A1H9Y H23  H N N 65  
A1H9Y H30  H N N 66  
A1H9Y H29  H N N 67  
A1H9Y H28  H N N 68  
A1H9Y H31  H N N 69  
A1H9Y H35  H N N 70  
ALA   N    N N N 71  
ALA   CA   C N S 72  
ALA   C    C N N 73  
ALA   O    O N N 74  
ALA   CB   C N N 75  
ALA   OXT  O N N 76  
ALA   H    H N N 77  
ALA   H2   H N N 78  
ALA   HA   H N N 79  
ALA   HB1  H N N 80  
ALA   HB2  H N N 81  
ALA   HB3  H N N 82  
ALA   HXT  H N N 83  
ARG   N    N N N 84  
ARG   CA   C N S 85  
ARG   C    C N N 86  
ARG   O    O N N 87  
ARG   CB   C N N 88  
ARG   CG   C N N 89  
ARG   CD   C N N 90  
ARG   NE   N N N 91  
ARG   CZ   C N N 92  
ARG   NH1  N N N 93  
ARG   NH2  N N N 94  
ARG   OXT  O N N 95  
ARG   H    H N N 96  
ARG   H2   H N N 97  
ARG   HA   H N N 98  
ARG   HB2  H N N 99  
ARG   HB3  H N N 100 
ARG   HG2  H N N 101 
ARG   HG3  H N N 102 
ARG   HD2  H N N 103 
ARG   HD3  H N N 104 
ARG   HE   H N N 105 
ARG   HH11 H N N 106 
ARG   HH12 H N N 107 
ARG   HH21 H N N 108 
ARG   HH22 H N N 109 
ARG   HXT  H N N 110 
ASN   N    N N N 111 
ASN   CA   C N S 112 
ASN   C    C N N 113 
ASN   O    O N N 114 
ASN   CB   C N N 115 
ASN   CG   C N N 116 
ASN   OD1  O N N 117 
ASN   ND2  N N N 118 
ASN   OXT  O N N 119 
ASN   H    H N N 120 
ASN   H2   H N N 121 
ASN   HA   H N N 122 
ASN   HB2  H N N 123 
ASN   HB3  H N N 124 
ASN   HD21 H N N 125 
ASN   HD22 H N N 126 
ASN   HXT  H N N 127 
ASP   N    N N N 128 
ASP   CA   C N S 129 
ASP   C    C N N 130 
ASP   O    O N N 131 
ASP   CB   C N N 132 
ASP   CG   C N N 133 
ASP   OD1  O N N 134 
ASP   OD2  O N N 135 
ASP   OXT  O N N 136 
ASP   H    H N N 137 
ASP   H2   H N N 138 
ASP   HA   H N N 139 
ASP   HB2  H N N 140 
ASP   HB3  H N N 141 
ASP   HD2  H N N 142 
ASP   HXT  H N N 143 
CYS   N    N N N 144 
CYS   CA   C N R 145 
CYS   C    C N N 146 
CYS   O    O N N 147 
CYS   CB   C N N 148 
CYS   SG   S N N 149 
CYS   OXT  O N N 150 
CYS   H    H N N 151 
CYS   H2   H N N 152 
CYS   HA   H N N 153 
CYS   HB2  H N N 154 
CYS   HB3  H N N 155 
CYS   HG   H N N 156 
CYS   HXT  H N N 157 
GLN   N    N N N 158 
GLN   CA   C N S 159 
GLN   C    C N N 160 
GLN   O    O N N 161 
GLN   CB   C N N 162 
GLN   CG   C N N 163 
GLN   CD   C N N 164 
GLN   OE1  O N N 165 
GLN   NE2  N N N 166 
GLN   OXT  O N N 167 
GLN   H    H N N 168 
GLN   H2   H N N 169 
GLN   HA   H N N 170 
GLN   HB2  H N N 171 
GLN   HB3  H N N 172 
GLN   HG2  H N N 173 
GLN   HG3  H N N 174 
GLN   HE21 H N N 175 
GLN   HE22 H N N 176 
GLN   HXT  H N N 177 
GLU   N    N N N 178 
GLU   CA   C N S 179 
GLU   C    C N N 180 
GLU   O    O N N 181 
GLU   CB   C N N 182 
GLU   CG   C N N 183 
GLU   CD   C N N 184 
GLU   OE1  O N N 185 
GLU   OE2  O N N 186 
GLU   OXT  O N N 187 
GLU   H    H N N 188 
GLU   H2   H N N 189 
GLU   HA   H N N 190 
GLU   HB2  H N N 191 
GLU   HB3  H N N 192 
GLU   HG2  H N N 193 
GLU   HG3  H N N 194 
GLU   HE2  H N N 195 
GLU   HXT  H N N 196 
GLY   N    N N N 197 
GLY   CA   C N N 198 
GLY   C    C N N 199 
GLY   O    O N N 200 
GLY   OXT  O N N 201 
GLY   H    H N N 202 
GLY   H2   H N N 203 
GLY   HA2  H N N 204 
GLY   HA3  H N N 205 
GLY   HXT  H N N 206 
HIS   N    N N N 207 
HIS   CA   C N S 208 
HIS   C    C N N 209 
HIS   O    O N N 210 
HIS   CB   C N N 211 
HIS   CG   C Y N 212 
HIS   ND1  N Y N 213 
HIS   CD2  C Y N 214 
HIS   CE1  C Y N 215 
HIS   NE2  N Y N 216 
HIS   OXT  O N N 217 
HIS   H    H N N 218 
HIS   H2   H N N 219 
HIS   HA   H N N 220 
HIS   HB2  H N N 221 
HIS   HB3  H N N 222 
HIS   HD1  H N N 223 
HIS   HD2  H N N 224 
HIS   HE1  H N N 225 
HIS   HE2  H N N 226 
HIS   HXT  H N N 227 
HOH   O    O N N 228 
HOH   H1   H N N 229 
HOH   H2   H N N 230 
ILE   N    N N N 231 
ILE   CA   C N S 232 
ILE   C    C N N 233 
ILE   O    O N N 234 
ILE   CB   C N S 235 
ILE   CG1  C N N 236 
ILE   CG2  C N N 237 
ILE   CD1  C N N 238 
ILE   OXT  O N N 239 
ILE   H    H N N 240 
ILE   H2   H N N 241 
ILE   HA   H N N 242 
ILE   HB   H N N 243 
ILE   HG12 H N N 244 
ILE   HG13 H N N 245 
ILE   HG21 H N N 246 
ILE   HG22 H N N 247 
ILE   HG23 H N N 248 
ILE   HD11 H N N 249 
ILE   HD12 H N N 250 
ILE   HD13 H N N 251 
ILE   HXT  H N N 252 
LEU   N    N N N 253 
LEU   CA   C N S 254 
LEU   C    C N N 255 
LEU   O    O N N 256 
LEU   CB   C N N 257 
LEU   CG   C N N 258 
LEU   CD1  C N N 259 
LEU   CD2  C N N 260 
LEU   OXT  O N N 261 
LEU   H    H N N 262 
LEU   H2   H N N 263 
LEU   HA   H N N 264 
LEU   HB2  H N N 265 
LEU   HB3  H N N 266 
LEU   HG   H N N 267 
LEU   HD11 H N N 268 
LEU   HD12 H N N 269 
LEU   HD13 H N N 270 
LEU   HD21 H N N 271 
LEU   HD22 H N N 272 
LEU   HD23 H N N 273 
LEU   HXT  H N N 274 
LYS   N    N N N 275 
LYS   CA   C N S 276 
LYS   C    C N N 277 
LYS   O    O N N 278 
LYS   CB   C N N 279 
LYS   CG   C N N 280 
LYS   CD   C N N 281 
LYS   CE   C N N 282 
LYS   NZ   N N N 283 
LYS   OXT  O N N 284 
LYS   H    H N N 285 
LYS   H2   H N N 286 
LYS   HA   H N N 287 
LYS   HB2  H N N 288 
LYS   HB3  H N N 289 
LYS   HG2  H N N 290 
LYS   HG3  H N N 291 
LYS   HD2  H N N 292 
LYS   HD3  H N N 293 
LYS   HE2  H N N 294 
LYS   HE3  H N N 295 
LYS   HZ1  H N N 296 
LYS   HZ2  H N N 297 
LYS   HZ3  H N N 298 
LYS   HXT  H N N 299 
MET   N    N N N 300 
MET   CA   C N S 301 
MET   C    C N N 302 
MET   O    O N N 303 
MET   CB   C N N 304 
MET   CG   C N N 305 
MET   SD   S N N 306 
MET   CE   C N N 307 
MET   OXT  O N N 308 
MET   H    H N N 309 
MET   H2   H N N 310 
MET   HA   H N N 311 
MET   HB2  H N N 312 
MET   HB3  H N N 313 
MET   HG2  H N N 314 
MET   HG3  H N N 315 
MET   HE1  H N N 316 
MET   HE2  H N N 317 
MET   HE3  H N N 318 
MET   HXT  H N N 319 
PHE   N    N N N 320 
PHE   CA   C N S 321 
PHE   C    C N N 322 
PHE   O    O N N 323 
PHE   CB   C N N 324 
PHE   CG   C Y N 325 
PHE   CD1  C Y N 326 
PHE   CD2  C Y N 327 
PHE   CE1  C Y N 328 
PHE   CE2  C Y N 329 
PHE   CZ   C Y N 330 
PHE   OXT  O N N 331 
PHE   H    H N N 332 
PHE   H2   H N N 333 
PHE   HA   H N N 334 
PHE   HB2  H N N 335 
PHE   HB3  H N N 336 
PHE   HD1  H N N 337 
PHE   HD2  H N N 338 
PHE   HE1  H N N 339 
PHE   HE2  H N N 340 
PHE   HZ   H N N 341 
PHE   HXT  H N N 342 
PRO   N    N N N 343 
PRO   CA   C N S 344 
PRO   C    C N N 345 
PRO   O    O N N 346 
PRO   CB   C N N 347 
PRO   CG   C N N 348 
PRO   CD   C N N 349 
PRO   OXT  O N N 350 
PRO   H    H N N 351 
PRO   HA   H N N 352 
PRO   HB2  H N N 353 
PRO   HB3  H N N 354 
PRO   HG2  H N N 355 
PRO   HG3  H N N 356 
PRO   HD2  H N N 357 
PRO   HD3  H N N 358 
PRO   HXT  H N N 359 
SER   N    N N N 360 
SER   CA   C N S 361 
SER   C    C N N 362 
SER   O    O N N 363 
SER   CB   C N N 364 
SER   OG   O N N 365 
SER   OXT  O N N 366 
SER   H    H N N 367 
SER   H2   H N N 368 
SER   HA   H N N 369 
SER   HB2  H N N 370 
SER   HB3  H N N 371 
SER   HG   H N N 372 
SER   HXT  H N N 373 
THR   N    N N N 374 
THR   CA   C N S 375 
THR   C    C N N 376 
THR   O    O N N 377 
THR   CB   C N R 378 
THR   OG1  O N N 379 
THR   CG2  C N N 380 
THR   OXT  O N N 381 
THR   H    H N N 382 
THR   H2   H N N 383 
THR   HA   H N N 384 
THR   HB   H N N 385 
THR   HG1  H N N 386 
THR   HG21 H N N 387 
THR   HG22 H N N 388 
THR   HG23 H N N 389 
THR   HXT  H N N 390 
TRP   N    N N N 391 
TRP   CA   C N S 392 
TRP   C    C N N 393 
TRP   O    O N N 394 
TRP   CB   C N N 395 
TRP   CG   C Y N 396 
TRP   CD1  C Y N 397 
TRP   CD2  C Y N 398 
TRP   NE1  N Y N 399 
TRP   CE2  C Y N 400 
TRP   CE3  C Y N 401 
TRP   CZ2  C Y N 402 
TRP   CZ3  C Y N 403 
TRP   CH2  C Y N 404 
TRP   OXT  O N N 405 
TRP   H    H N N 406 
TRP   H2   H N N 407 
TRP   HA   H N N 408 
TRP   HB2  H N N 409 
TRP   HB3  H N N 410 
TRP   HD1  H N N 411 
TRP   HE1  H N N 412 
TRP   HE3  H N N 413 
TRP   HZ2  H N N 414 
TRP   HZ3  H N N 415 
TRP   HH2  H N N 416 
TRP   HXT  H N N 417 
TYR   N    N N N 418 
TYR   CA   C N S 419 
TYR   C    C N N 420 
TYR   O    O N N 421 
TYR   CB   C N N 422 
TYR   CG   C Y N 423 
TYR   CD1  C Y N 424 
TYR   CD2  C Y N 425 
TYR   CE1  C Y N 426 
TYR   CE2  C Y N 427 
TYR   CZ   C Y N 428 
TYR   OH   O N N 429 
TYR   OXT  O N N 430 
TYR   H    H N N 431 
TYR   H2   H N N 432 
TYR   HA   H N N 433 
TYR   HB2  H N N 434 
TYR   HB3  H N N 435 
TYR   HD1  H N N 436 
TYR   HD2  H N N 437 
TYR   HE1  H N N 438 
TYR   HE2  H N N 439 
TYR   HH   H N N 440 
TYR   HXT  H N N 441 
VAL   N    N N N 442 
VAL   CA   C N S 443 
VAL   C    C N N 444 
VAL   O    O N N 445 
VAL   CB   C N N 446 
VAL   CG1  C N N 447 
VAL   CG2  C N N 448 
VAL   OXT  O N N 449 
VAL   H    H N N 450 
VAL   H2   H N N 451 
VAL   HA   H N N 452 
VAL   HB   H N N 453 
VAL   HG11 H N N 454 
VAL   HG12 H N N 455 
VAL   HG13 H N N 456 
VAL   HG21 H N N 457 
VAL   HG22 H N N 458 
VAL   HG23 H N N 459 
VAL   HXT  H N N 460 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1H9Y C1  C2   sing N N 1   
A1H9Y C2  C3   doub N N 2   
A1H9Y C3  C4   sing N N 3   
A1H9Y C4  N1   sing N N 4   
A1H9Y N1  C5   sing N N 5   
A1H9Y C1  C5   doub N N 6   
A1H9Y N1  C6   sing N N 7   
A1H9Y C3  N2   sing N N 8   
A1H9Y C6  C7   sing N N 9   
A1H9Y C7  N3   sing N N 10  
A1H9Y N3  C8   sing N N 11  
A1H9Y C6  C9   sing N N 12  
A1H9Y C9  C10  sing N N 13  
A1H9Y C10 C11  sing N N 14  
A1H9Y C11 C12  sing N N 15  
A1H9Y C10 C12  sing N N 16  
A1H9Y C7  O1   doub N N 17  
A1H9Y C4  O2   doub N N 18  
A1H9Y C8  C13  sing N N 19  
A1H9Y C8  C14  sing N N 20  
A1H9Y C13 C15  sing N N 21  
A1H9Y C14 C16  sing N N 22  
A1H9Y C16 C17  sing N N 23  
A1H9Y C17 C18  sing N N 24  
A1H9Y C18 N4   sing N N 25  
A1H9Y N4  C19  sing N N 26  
A1H9Y C16 C19  sing N N 27  
A1H9Y C19 O3   doub N N 28  
A1H9Y N2  C20  sing N N 29  
A1H9Y C20 C21  sing N N 30  
A1H9Y C21 C22  sing N N 31  
A1H9Y C21 C23  sing N N 32  
A1H9Y C15 N5   sing N N 33  
A1H9Y N5  C24  sing N N 34  
A1H9Y C20 O4   doub N N 35  
A1H9Y C15 O5   doub N N 36  
A1H9Y C13 O6   sing N N 37  
A1H9Y N3  H6   sing N N 38  
A1H9Y C5  H3   sing N N 39  
A1H9Y C6  H4   sing N N 40  
A1H9Y C8  H7   sing N N 41  
A1H9Y C10 H10  sing N N 42  
A1H9Y C13 H15  sing N N 43  
A1H9Y C17 H19  sing N N 44  
A1H9Y C17 H20  sing N N 45  
A1H9Y C21 H24  sing N N 46  
A1H9Y C22 H26  sing N N 47  
A1H9Y C22 H25  sing N N 48  
A1H9Y C22 H27  sing N N 49  
A1H9Y C24 H34  sing N N 50  
A1H9Y C24 H33  sing N N 51  
A1H9Y C24 H32  sing N N 52  
A1H9Y C1  H1   sing N N 53  
A1H9Y C2  H2   sing N N 54  
A1H9Y N2  H5   sing N N 55  
A1H9Y C9  H9   sing N N 56  
A1H9Y C9  H8   sing N N 57  
A1H9Y C11 H11  sing N N 58  
A1H9Y C11 H12  sing N N 59  
A1H9Y C12 H13  sing N N 60  
A1H9Y C12 H14  sing N N 61  
A1H9Y C14 H16  sing N N 62  
A1H9Y C14 H17  sing N N 63  
A1H9Y C16 H18  sing N N 64  
A1H9Y C18 H21  sing N N 65  
A1H9Y C18 H22  sing N N 66  
A1H9Y N4  H23  sing N N 67  
A1H9Y C23 H30  sing N N 68  
A1H9Y C23 H29  sing N N 69  
A1H9Y C23 H28  sing N N 70  
A1H9Y N5  H31  sing N N 71  
A1H9Y O6  H35  sing N N 72  
ALA   N   CA   sing N N 73  
ALA   N   H    sing N N 74  
ALA   N   H2   sing N N 75  
ALA   CA  C    sing N N 76  
ALA   CA  CB   sing N N 77  
ALA   CA  HA   sing N N 78  
ALA   C   O    doub N N 79  
ALA   C   OXT  sing N N 80  
ALA   CB  HB1  sing N N 81  
ALA   CB  HB2  sing N N 82  
ALA   CB  HB3  sing N N 83  
ALA   OXT HXT  sing N N 84  
ARG   N   CA   sing N N 85  
ARG   N   H    sing N N 86  
ARG   N   H2   sing N N 87  
ARG   CA  C    sing N N 88  
ARG   CA  CB   sing N N 89  
ARG   CA  HA   sing N N 90  
ARG   C   O    doub N N 91  
ARG   C   OXT  sing N N 92  
ARG   CB  CG   sing N N 93  
ARG   CB  HB2  sing N N 94  
ARG   CB  HB3  sing N N 95  
ARG   CG  CD   sing N N 96  
ARG   CG  HG2  sing N N 97  
ARG   CG  HG3  sing N N 98  
ARG   CD  NE   sing N N 99  
ARG   CD  HD2  sing N N 100 
ARG   CD  HD3  sing N N 101 
ARG   NE  CZ   sing N N 102 
ARG   NE  HE   sing N N 103 
ARG   CZ  NH1  sing N N 104 
ARG   CZ  NH2  doub N N 105 
ARG   NH1 HH11 sing N N 106 
ARG   NH1 HH12 sing N N 107 
ARG   NH2 HH21 sing N N 108 
ARG   NH2 HH22 sing N N 109 
ARG   OXT HXT  sing N N 110 
ASN   N   CA   sing N N 111 
ASN   N   H    sing N N 112 
ASN   N   H2   sing N N 113 
ASN   CA  C    sing N N 114 
ASN   CA  CB   sing N N 115 
ASN   CA  HA   sing N N 116 
ASN   C   O    doub N N 117 
ASN   C   OXT  sing N N 118 
ASN   CB  CG   sing N N 119 
ASN   CB  HB2  sing N N 120 
ASN   CB  HB3  sing N N 121 
ASN   CG  OD1  doub N N 122 
ASN   CG  ND2  sing N N 123 
ASN   ND2 HD21 sing N N 124 
ASN   ND2 HD22 sing N N 125 
ASN   OXT HXT  sing N N 126 
ASP   N   CA   sing N N 127 
ASP   N   H    sing N N 128 
ASP   N   H2   sing N N 129 
ASP   CA  C    sing N N 130 
ASP   CA  CB   sing N N 131 
ASP   CA  HA   sing N N 132 
ASP   C   O    doub N N 133 
ASP   C   OXT  sing N N 134 
ASP   CB  CG   sing N N 135 
ASP   CB  HB2  sing N N 136 
ASP   CB  HB3  sing N N 137 
ASP   CG  OD1  doub N N 138 
ASP   CG  OD2  sing N N 139 
ASP   OD2 HD2  sing N N 140 
ASP   OXT HXT  sing N N 141 
CYS   N   CA   sing N N 142 
CYS   N   H    sing N N 143 
CYS   N   H2   sing N N 144 
CYS   CA  C    sing N N 145 
CYS   CA  CB   sing N N 146 
CYS   CA  HA   sing N N 147 
CYS   C   O    doub N N 148 
CYS   C   OXT  sing N N 149 
CYS   CB  SG   sing N N 150 
CYS   CB  HB2  sing N N 151 
CYS   CB  HB3  sing N N 152 
CYS   SG  HG   sing N N 153 
CYS   OXT HXT  sing N N 154 
GLN   N   CA   sing N N 155 
GLN   N   H    sing N N 156 
GLN   N   H2   sing N N 157 
GLN   CA  C    sing N N 158 
GLN   CA  CB   sing N N 159 
GLN   CA  HA   sing N N 160 
GLN   C   O    doub N N 161 
GLN   C   OXT  sing N N 162 
GLN   CB  CG   sing N N 163 
GLN   CB  HB2  sing N N 164 
GLN   CB  HB3  sing N N 165 
GLN   CG  CD   sing N N 166 
GLN   CG  HG2  sing N N 167 
GLN   CG  HG3  sing N N 168 
GLN   CD  OE1  doub N N 169 
GLN   CD  NE2  sing N N 170 
GLN   NE2 HE21 sing N N 171 
GLN   NE2 HE22 sing N N 172 
GLN   OXT HXT  sing N N 173 
GLU   N   CA   sing N N 174 
GLU   N   H    sing N N 175 
GLU   N   H2   sing N N 176 
GLU   CA  C    sing N N 177 
GLU   CA  CB   sing N N 178 
GLU   CA  HA   sing N N 179 
GLU   C   O    doub N N 180 
GLU   C   OXT  sing N N 181 
GLU   CB  CG   sing N N 182 
GLU   CB  HB2  sing N N 183 
GLU   CB  HB3  sing N N 184 
GLU   CG  CD   sing N N 185 
GLU   CG  HG2  sing N N 186 
GLU   CG  HG3  sing N N 187 
GLU   CD  OE1  doub N N 188 
GLU   CD  OE2  sing N N 189 
GLU   OE2 HE2  sing N N 190 
GLU   OXT HXT  sing N N 191 
GLY   N   CA   sing N N 192 
GLY   N   H    sing N N 193 
GLY   N   H2   sing N N 194 
GLY   CA  C    sing N N 195 
GLY   CA  HA2  sing N N 196 
GLY   CA  HA3  sing N N 197 
GLY   C   O    doub N N 198 
GLY   C   OXT  sing N N 199 
GLY   OXT HXT  sing N N 200 
HIS   N   CA   sing N N 201 
HIS   N   H    sing N N 202 
HIS   N   H2   sing N N 203 
HIS   CA  C    sing N N 204 
HIS   CA  CB   sing N N 205 
HIS   CA  HA   sing N N 206 
HIS   C   O    doub N N 207 
HIS   C   OXT  sing N N 208 
HIS   CB  CG   sing N N 209 
HIS   CB  HB2  sing N N 210 
HIS   CB  HB3  sing N N 211 
HIS   CG  ND1  sing Y N 212 
HIS   CG  CD2  doub Y N 213 
HIS   ND1 CE1  doub Y N 214 
HIS   ND1 HD1  sing N N 215 
HIS   CD2 NE2  sing Y N 216 
HIS   CD2 HD2  sing N N 217 
HIS   CE1 NE2  sing Y N 218 
HIS   CE1 HE1  sing N N 219 
HIS   NE2 HE2  sing N N 220 
HIS   OXT HXT  sing N N 221 
HOH   O   H1   sing N N 222 
HOH   O   H2   sing N N 223 
ILE   N   CA   sing N N 224 
ILE   N   H    sing N N 225 
ILE   N   H2   sing N N 226 
ILE   CA  C    sing N N 227 
ILE   CA  CB   sing N N 228 
ILE   CA  HA   sing N N 229 
ILE   C   O    doub N N 230 
ILE   C   OXT  sing N N 231 
ILE   CB  CG1  sing N N 232 
ILE   CB  CG2  sing N N 233 
ILE   CB  HB   sing N N 234 
ILE   CG1 CD1  sing N N 235 
ILE   CG1 HG12 sing N N 236 
ILE   CG1 HG13 sing N N 237 
ILE   CG2 HG21 sing N N 238 
ILE   CG2 HG22 sing N N 239 
ILE   CG2 HG23 sing N N 240 
ILE   CD1 HD11 sing N N 241 
ILE   CD1 HD12 sing N N 242 
ILE   CD1 HD13 sing N N 243 
ILE   OXT HXT  sing N N 244 
LEU   N   CA   sing N N 245 
LEU   N   H    sing N N 246 
LEU   N   H2   sing N N 247 
LEU   CA  C    sing N N 248 
LEU   CA  CB   sing N N 249 
LEU   CA  HA   sing N N 250 
LEU   C   O    doub N N 251 
LEU   C   OXT  sing N N 252 
LEU   CB  CG   sing N N 253 
LEU   CB  HB2  sing N N 254 
LEU   CB  HB3  sing N N 255 
LEU   CG  CD1  sing N N 256 
LEU   CG  CD2  sing N N 257 
LEU   CG  HG   sing N N 258 
LEU   CD1 HD11 sing N N 259 
LEU   CD1 HD12 sing N N 260 
LEU   CD1 HD13 sing N N 261 
LEU   CD2 HD21 sing N N 262 
LEU   CD2 HD22 sing N N 263 
LEU   CD2 HD23 sing N N 264 
LEU   OXT HXT  sing N N 265 
LYS   N   CA   sing N N 266 
LYS   N   H    sing N N 267 
LYS   N   H2   sing N N 268 
LYS   CA  C    sing N N 269 
LYS   CA  CB   sing N N 270 
LYS   CA  HA   sing N N 271 
LYS   C   O    doub N N 272 
LYS   C   OXT  sing N N 273 
LYS   CB  CG   sing N N 274 
LYS   CB  HB2  sing N N 275 
LYS   CB  HB3  sing N N 276 
LYS   CG  CD   sing N N 277 
LYS   CG  HG2  sing N N 278 
LYS   CG  HG3  sing N N 279 
LYS   CD  CE   sing N N 280 
LYS   CD  HD2  sing N N 281 
LYS   CD  HD3  sing N N 282 
LYS   CE  NZ   sing N N 283 
LYS   CE  HE2  sing N N 284 
LYS   CE  HE3  sing N N 285 
LYS   NZ  HZ1  sing N N 286 
LYS   NZ  HZ2  sing N N 287 
LYS   NZ  HZ3  sing N N 288 
LYS   OXT HXT  sing N N 289 
MET   N   CA   sing N N 290 
MET   N   H    sing N N 291 
MET   N   H2   sing N N 292 
MET   CA  C    sing N N 293 
MET   CA  CB   sing N N 294 
MET   CA  HA   sing N N 295 
MET   C   O    doub N N 296 
MET   C   OXT  sing N N 297 
MET   CB  CG   sing N N 298 
MET   CB  HB2  sing N N 299 
MET   CB  HB3  sing N N 300 
MET   CG  SD   sing N N 301 
MET   CG  HG2  sing N N 302 
MET   CG  HG3  sing N N 303 
MET   SD  CE   sing N N 304 
MET   CE  HE1  sing N N 305 
MET   CE  HE2  sing N N 306 
MET   CE  HE3  sing N N 307 
MET   OXT HXT  sing N N 308 
PHE   N   CA   sing N N 309 
PHE   N   H    sing N N 310 
PHE   N   H2   sing N N 311 
PHE   CA  C    sing N N 312 
PHE   CA  CB   sing N N 313 
PHE   CA  HA   sing N N 314 
PHE   C   O    doub N N 315 
PHE   C   OXT  sing N N 316 
PHE   CB  CG   sing N N 317 
PHE   CB  HB2  sing N N 318 
PHE   CB  HB3  sing N N 319 
PHE   CG  CD1  doub Y N 320 
PHE   CG  CD2  sing Y N 321 
PHE   CD1 CE1  sing Y N 322 
PHE   CD1 HD1  sing N N 323 
PHE   CD2 CE2  doub Y N 324 
PHE   CD2 HD2  sing N N 325 
PHE   CE1 CZ   doub Y N 326 
PHE   CE1 HE1  sing N N 327 
PHE   CE2 CZ   sing Y N 328 
PHE   CE2 HE2  sing N N 329 
PHE   CZ  HZ   sing N N 330 
PHE   OXT HXT  sing N N 331 
PRO   N   CA   sing N N 332 
PRO   N   CD   sing N N 333 
PRO   N   H    sing N N 334 
PRO   CA  C    sing N N 335 
PRO   CA  CB   sing N N 336 
PRO   CA  HA   sing N N 337 
PRO   C   O    doub N N 338 
PRO   C   OXT  sing N N 339 
PRO   CB  CG   sing N N 340 
PRO   CB  HB2  sing N N 341 
PRO   CB  HB3  sing N N 342 
PRO   CG  CD   sing N N 343 
PRO   CG  HG2  sing N N 344 
PRO   CG  HG3  sing N N 345 
PRO   CD  HD2  sing N N 346 
PRO   CD  HD3  sing N N 347 
PRO   OXT HXT  sing N N 348 
SER   N   CA   sing N N 349 
SER   N   H    sing N N 350 
SER   N   H2   sing N N 351 
SER   CA  C    sing N N 352 
SER   CA  CB   sing N N 353 
SER   CA  HA   sing N N 354 
SER   C   O    doub N N 355 
SER   C   OXT  sing N N 356 
SER   CB  OG   sing N N 357 
SER   CB  HB2  sing N N 358 
SER   CB  HB3  sing N N 359 
SER   OG  HG   sing N N 360 
SER   OXT HXT  sing N N 361 
THR   N   CA   sing N N 362 
THR   N   H    sing N N 363 
THR   N   H2   sing N N 364 
THR   CA  C    sing N N 365 
THR   CA  CB   sing N N 366 
THR   CA  HA   sing N N 367 
THR   C   O    doub N N 368 
THR   C   OXT  sing N N 369 
THR   CB  OG1  sing N N 370 
THR   CB  CG2  sing N N 371 
THR   CB  HB   sing N N 372 
THR   OG1 HG1  sing N N 373 
THR   CG2 HG21 sing N N 374 
THR   CG2 HG22 sing N N 375 
THR   CG2 HG23 sing N N 376 
THR   OXT HXT  sing N N 377 
TRP   N   CA   sing N N 378 
TRP   N   H    sing N N 379 
TRP   N   H2   sing N N 380 
TRP   CA  C    sing N N 381 
TRP   CA  CB   sing N N 382 
TRP   CA  HA   sing N N 383 
TRP   C   O    doub N N 384 
TRP   C   OXT  sing N N 385 
TRP   CB  CG   sing N N 386 
TRP   CB  HB2  sing N N 387 
TRP   CB  HB3  sing N N 388 
TRP   CG  CD1  doub Y N 389 
TRP   CG  CD2  sing Y N 390 
TRP   CD1 NE1  sing Y N 391 
TRP   CD1 HD1  sing N N 392 
TRP   CD2 CE2  doub Y N 393 
TRP   CD2 CE3  sing Y N 394 
TRP   NE1 CE2  sing Y N 395 
TRP   NE1 HE1  sing N N 396 
TRP   CE2 CZ2  sing Y N 397 
TRP   CE3 CZ3  doub Y N 398 
TRP   CE3 HE3  sing N N 399 
TRP   CZ2 CH2  doub Y N 400 
TRP   CZ2 HZ2  sing N N 401 
TRP   CZ3 CH2  sing Y N 402 
TRP   CZ3 HZ3  sing N N 403 
TRP   CH2 HH2  sing N N 404 
TRP   OXT HXT  sing N N 405 
TYR   N   CA   sing N N 406 
TYR   N   H    sing N N 407 
TYR   N   H2   sing N N 408 
TYR   CA  C    sing N N 409 
TYR   CA  CB   sing N N 410 
TYR   CA  HA   sing N N 411 
TYR   C   O    doub N N 412 
TYR   C   OXT  sing N N 413 
TYR   CB  CG   sing N N 414 
TYR   CB  HB2  sing N N 415 
TYR   CB  HB3  sing N N 416 
TYR   CG  CD1  doub Y N 417 
TYR   CG  CD2  sing Y N 418 
TYR   CD1 CE1  sing Y N 419 
TYR   CD1 HD1  sing N N 420 
TYR   CD2 CE2  doub Y N 421 
TYR   CD2 HD2  sing N N 422 
TYR   CE1 CZ   doub Y N 423 
TYR   CE1 HE1  sing N N 424 
TYR   CE2 CZ   sing Y N 425 
TYR   CE2 HE2  sing N N 426 
TYR   CZ  OH   sing N N 427 
TYR   OH  HH   sing N N 428 
TYR   OXT HXT  sing N N 429 
VAL   N   CA   sing N N 430 
VAL   N   H    sing N N 431 
VAL   N   H2   sing N N 432 
VAL   CA  C    sing N N 433 
VAL   CA  CB   sing N N 434 
VAL   CA  HA   sing N N 435 
VAL   C   O    doub N N 436 
VAL   C   OXT  sing N N 437 
VAL   CB  CG1  sing N N 438 
VAL   CB  CG2  sing N N 439 
VAL   CB  HB   sing N N 440 
VAL   CG1 HG11 sing N N 441 
VAL   CG1 HG12 sing N N 442 
VAL   CG1 HG13 sing N N 443 
VAL   CG2 HG21 sing N N 444 
VAL   CG2 HG22 sing N N 445 
VAL   CG2 HG23 sing N N 446 
VAL   OXT HXT  sing N N 447 
# 
_pdbx_audit_support.funding_organization   'European Commission' 
_pdbx_audit_support.country                'European Union' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6y2e 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9F39 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008795 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001941 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018798 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022830 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
H 1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N 7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O 8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
S 16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0650   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . SER   A 1 1   ? -2.461  -22.339 38.734  1.000 71.073  0 1   SER   A N   1 ? 
ATOM   2    C CA  . SER   A 1 1   ? -2.992  -21.093 38.121  1.000 72.245  0 1   SER   A CA  1 ? 
ATOM   3    C C   . SER   A 1 1   ? -2.377  -20.871 36.734  1.000 66.271  0 1   SER   A C   1 ? 
ATOM   4    O O   . SER   A 1 1   ? -1.679  -21.735 36.201  1.000 62.516  0 1   SER   A O   1 ? 
ATOM   5    C CB  . SER   A 1 1   ? -2.786  -19.912 39.048  1.000 79.300  0 1   SER   A CB  1 ? 
ATOM   6    O OG  . SER   A 1 1   ? -1.431  -19.486 39.052  1.000 85.680  0 1   SER   A OG  1 ? 
ATOM   7    N N   . GLY   A 1 2   ? -2.650  -19.696 36.154  1.000 61.335  0 2   GLY   A N   1 ? 
ATOM   8    C CA  . GLY   A 1 2   ? -2.455  -19.469 34.734  1.000 55.979  0 2   GLY   A CA  1 ? 
ATOM   9    C C   . GLY   A 1 2   ? -3.698  -19.889 33.956  1.000 52.659  0 2   GLY   A C   1 ? 
ATOM   10   O O   . GLY   A 1 2   ? -4.523  -20.661 34.447  1.000 48.497  0 2   GLY   A O   1 ? 
ATOM   11   N N   . PHE   A 1 3   ? -3.844  -19.357 32.745  1.000 48.176  0 3   PHE   A N   1 ? 
ATOM   12   C CA  . PHE   A 1 3   ? -5.050  -19.603 31.977  1.000 47.468  0 3   PHE   A CA  1 ? 
ATOM   13   C C   . PHE   A 1 3   ? -4.703  -19.566 30.498  1.000 47.038  0 3   PHE   A C   1 ? 
ATOM   14   O O   . PHE   A 1 3   ? -4.033  -18.647 30.043  1.000 51.204  0 3   PHE   A O   1 ? 
ATOM   15   C CB  . PHE   A 1 3   ? -6.130  -18.570 32.306  1.000 44.999  0 3   PHE   A CB  1 ? 
ATOM   16   C CG  . PHE   A 1 3   ? -7.541  -19.012 32.017  1.000 40.990  0 3   PHE   A CG  1 ? 
ATOM   17   C CD1 . PHE   A 1 3   ? -8.231  -19.795 32.925  1.000 41.400  0 3   PHE   A CD1 1 ? 
ATOM   18   C CD2 . PHE   A 1 3   ? -8.173  -18.664 30.836  1.000 40.210  0 3   PHE   A CD2 1 ? 
ATOM   19   C CE1 . PHE   A 1 3   ? -9.528  -20.212 32.665  1.000 41.884  0 3   PHE   A CE1 1 ? 
ATOM   20   C CE2 . PHE   A 1 3   ? -9.475  -19.069 30.583  1.000 42.341  0 3   PHE   A CE2 1 ? 
ATOM   21   C CZ  . PHE   A 1 3   ? -10.152 -19.840 31.499  1.000 41.693  0 3   PHE   A CZ  1 ? 
ATOM   22   N N   . ARG   A 1 4   ? -5.184  -20.564 29.761  1.000 45.997  0 4   ARG   A N   1 ? 
ATOM   23   C CA  . ARG   A 1 4   ? -4.837  -20.714 28.362  1.000 46.105  0 4   ARG   A CA  1 ? 
ATOM   24   C C   . ARG   A 1 4   ? -6.037  -21.256 27.594  1.000 45.693  0 4   ARG   A C   1 ? 
ATOM   25   O O   . ARG   A 1 4   ? -7.007  -21.708 28.182  1.000 44.240  0 4   ARG   A O   1 ? 
ATOM   26   C CB  . ARG   A 1 4   ? -3.614  -21.627 28.248  1.000 46.285  0 4   ARG   A CB  1 ? 
ATOM   27   C CG  . ARG   A 1 4   ? -2.296  -20.874 28.170  1.000 50.740  0 4   ARG   A CG  1 ? 
ATOM   28   C CD  . ARG   A 1 4   ? -1.328  -21.612 27.273  1.000 56.492  0 4   ARG   A CD  1 ? 
ATOM   29   N NE  . ARG   A 1 4   ? -0.127  -20.832 27.064  1.000 62.273  0 4   ARG   A NE  1 ? 
ATOM   30   C CZ  . ARG   A 1 4   ? 0.165   -20.159 25.959  1.000 72.293  0 4   ARG   A CZ  1 ? 
ATOM   31   N NH1 . ARG   A 1 4   ? 1.229   -19.378 25.941  1.000 72.398  0 4   ARG   A NH1 1 ? 
ATOM   32   N NH2 . ARG   A 1 4   ? -0.618  -20.231 24.894  1.000 76.090  0 4   ARG   A NH2 1 ? 
ATOM   33   N N   . LYS   A 1 5   ? -5.978  -21.176 26.265  1.000 51.475  0 5   LYS   A N   1 ? 
ATOM   34   C CA  . LYS   A 1 5   ? -6.894  -21.920 25.415  1.000 51.592  0 5   LYS   A CA  1 ? 
ATOM   35   C C   . LYS   A 1 5   ? -6.370  -23.353 25.263  1.000 50.340  0 5   LYS   A C   1 ? 
ATOM   36   O O   . LYS   A 1 5   ? -5.249  -23.562 24.789  1.000 46.874  0 5   LYS   A O   1 ? 
ATOM   37   C CB  . LYS   A 1 5   ? -7.053  -21.215 24.065  1.000 52.636  0 5   LYS   A CB  1 ? 
ATOM   38   C CG  . LYS   A 1 5   ? -8.139  -21.808 23.185  1.000 59.302  0 5   LYS   A CG  1 ? 
ATOM   39   C CD  . LYS   A 1 5   ? -8.919  -20.772 22.417  1.000 66.520  0 5   LYS   A CD  1 ? 
ATOM   40   C CE  . LYS   A 1 5   ? -9.947  -20.068 23.274  1.000 65.349  0 5   LYS   A CE  1 ? 
ATOM   41   N NZ  . LYS   A 1 5   ? -10.589 -18.968 22.527  1.000 66.295  0 5   LYS   A NZ  1 ? 
ATOM   42   N N   . MET   A 1 6   ? -7.184  -24.334 25.689  1.000 44.699  0 6   MET   A N   1 ? 
ATOM   43   C CA  . MET   A 1 6   ? -6.764  -25.722 25.663  1.000 44.622  0 6   MET   A CA  1 ? 
ATOM   44   C C   . MET   A 1 6   ? -7.913  -26.618 25.221  1.000 43.409  0 6   MET   A C   1 ? 
ATOM   45   O O   . MET   A 1 6   ? -9.070  -26.381 25.548  1.000 44.132  0 6   MET   A O   1 ? 
ATOM   46   C CB  . MET   A 1 6   ? -6.280  -26.190 27.035  1.000 48.024  0 6   MET   A CB  1 ? 
ATOM   47   C CG  . MET   A 1 6   ? -7.325  -26.150 28.124  1.000 50.930  0 6   MET   A CG  1 ? 
ATOM   48   S SD  . MET   A 1 6   ? -6.726  -27.046 29.574  1.000 55.811  0 6   MET   A SD  1 ? 
ATOM   49   C CE  . MET   A 1 6   ? -5.709  -25.792 30.349  1.000 52.288  0 6   MET   A CE  1 ? 
ATOM   50   N N   . ALA   A 1 7   ? -7.563  -27.678 24.497  1.000 41.395  0 7   ALA   A N   1 ? 
ATOM   51   C CA  . ALA   A 1 7   ? -8.553  -28.617 24.019  1.000 39.416  0 7   ALA   A CA  1 ? 
ATOM   52   C C   . ALA   A 1 7   ? -8.531  -29.813 24.941  1.000 38.097  0 7   ALA   A C   1 ? 
ATOM   53   O O   . ALA   A 1 7   ? -7.505  -30.041 25.574  1.000 35.017  0 7   ALA   A O   1 ? 
ATOM   54   C CB  . ALA   A 1 7   ? -8.236  -29.030 22.612  1.000 39.387  0 7   ALA   A CB  1 ? 
ATOM   55   N N   . PHE   A 1 8   ? -9.666  -30.527 24.994  1.000 40.135  0 8   PHE   A N   1 ? 
ATOM   56   C CA  . PHE   A 1 8   ? -9.707  -31.905 25.452  1.000 42.838  0 8   PHE   A CA  1 ? 
ATOM   57   C C   . PHE   A 1 8   ? -8.589  -32.690 24.767  1.000 48.263  0 8   PHE   A C   1 ? 
ATOM   58   O O   . PHE   A 1 8   ? -8.099  -32.297 23.706  1.000 46.488  0 8   PHE   A O   1 ? 
ATOM   59   C CB  . PHE   A 1 8   ? -11.037 -32.580 25.099  1.000 44.315  0 8   PHE   A CB  1 ? 
ATOM   60   C CG  . PHE   A 1 8   ? -12.261 -31.848 25.576  1.000 47.852  0 8   PHE   A CG  1 ? 
ATOM   61   C CD1 . PHE   A 1 8   ? -12.673 -31.921 26.895  1.000 51.401  0 8   PHE   A CD1 1 ? 
ATOM   62   C CD2 . PHE   A 1 8   ? -12.979 -31.044 24.710  1.000 51.992  0 8   PHE   A CD2 1 ? 
ATOM   63   C CE1 . PHE   A 1 8   ? -13.791 -31.224 27.331  1.000 54.150  0 8   PHE   A CE1 1 ? 
ATOM   64   C CE2 . PHE   A 1 8   ? -14.086 -30.335 25.149  1.000 53.633  0 8   PHE   A CE2 1 ? 
ATOM   65   C CZ  . PHE   A 1 8   ? -14.495 -30.428 26.459  1.000 54.249  0 8   PHE   A CZ  1 ? 
ATOM   66   N N   . PRO   A 1 9   ? -8.166  -33.847 25.324  1.000 57.484  0 9   PRO   A N   1 ? 
ATOM   67   C CA  . PRO   A 1 9   ? -7.230  -34.732 24.627  1.000 57.890  0 9   PRO   A CA  1 ? 
ATOM   68   C C   . PRO   A 1 9   ? -7.872  -35.309 23.364  1.000 52.720  0 9   PRO   A C   1 ? 
ATOM   69   O O   . PRO   A 1 9   ? -9.092  -35.397 23.273  1.000 59.083  0 9   PRO   A O   1 ? 
ATOM   70   C CB  . PRO   A 1 9   ? -6.911  -35.842 25.651  1.000 59.984  0 9   PRO   A CB  1 ? 
ATOM   71   C CG  . PRO   A 1 9   ? -7.427  -35.317 26.981  1.000 59.506  0 9   PRO   A CG  1 ? 
ATOM   72   C CD  . PRO   A 1 9   ? -8.570  -34.380 26.637  1.000 59.673  0 9   PRO   A CD  1 ? 
ATOM   73   N N   . SER   A 1 10  ? -7.046  -35.700 22.393  1.000 48.214  0 10  SER   A N   1 ? 
ATOM   74   C CA  . SER   A 1 10  ? -7.540  -36.193 21.119  1.000 46.721  0 10  SER   A CA  1 ? 
ATOM   75   C C   . SER   A 1 10  ? -7.606  -37.717 21.136  1.000 45.327  0 10  SER   A C   1 ? 
ATOM   76   O O   . SER   A 1 10  ? -8.631  -38.290 20.790  1.000 44.798  0 10  SER   A O   1 ? 
ATOM   77   C CB  . SER   A 1 10  ? -6.705  -35.678 19.984  1.000 44.691  0 10  SER   A CB  1 ? 
ATOM   78   O OG  . SER   A 1 10  ? -5.329  -35.730 20.305  1.000 47.281  0 10  SER   A OG  1 ? 
ATOM   79   N N   . GLY   A 1 11  ? -6.510  -38.357 21.545  1.000 43.570  0 11  GLY   A N   1 ? 
ATOM   80   C CA  . GLY   A 1 11  ? -6.489  -39.781 21.828  1.000 44.705  0 11  GLY   A CA  1 ? 
ATOM   81   C C   . GLY   A 1 11  ? -7.736  -40.512 21.344  1.000 45.026  0 11  GLY   A C   1 ? 
ATOM   82   O O   . GLY   A 1 11  ? -7.670  -41.229 20.360  1.000 48.061  0 11  GLY   A O   1 ? 
ATOM   83   N N   . LYS   A 1 12  ? -8.864  -40.333 22.038  1.000 48.234  0 12  LYS   A N   1 ? 
ATOM   84   C CA  . LYS   A 1 12  ? -10.075 -41.096 21.757  1.000 51.162  0 12  LYS   A CA  1 ? 
ATOM   85   C C   . LYS   A 1 12  ? -10.575 -40.904 20.317  1.000 49.323  0 12  LYS   A C   1 ? 
ATOM   86   O O   . LYS   A 1 12  ? -11.031 -41.858 19.690  1.000 54.436  0 12  LYS   A O   1 ? 
ATOM   87   C CB  . LYS   A 1 12  ? -11.172 -40.738 22.764  1.000 51.840  0 12  LYS   A CB  1 ? 
ATOM   88   C CG  . LYS   A 1 12  ? -11.072 -41.447 24.106  1.000 55.014  0 12  LYS   A CG  1 ? 
ATOM   89   C CD  . LYS   A 1 12  ? -12.268 -41.181 24.997  1.000 63.227  0 12  LYS   A CD  1 ? 
ATOM   90   C CE  . LYS   A 1 12  ? -12.487 -42.237 26.063  1.000 69.598  0 12  LYS   A CE  1 ? 
ATOM   91   N NZ  . LYS   A 1 12  ? -11.498 -42.135 27.160  1.000 74.446  0 12  LYS   A NZ  1 ? 
ATOM   92   N N   . VAL   A 1 13  ? -10.494 -39.684 19.781  1.000 46.515  0 13  VAL   A N   1 ? 
ATOM   93   C CA  . VAL   A 1 13  ? -10.989 -39.407 18.442  1.000 43.721  0 13  VAL   A CA  1 ? 
ATOM   94   C C   . VAL   A 1 13  ? -9.983  -39.828 17.363  1.000 40.950  0 13  VAL   A C   1 ? 
ATOM   95   O O   . VAL   A 1 13  ? -10.409 -40.256 16.295  1.000 41.908  0 13  VAL   A O   1 ? 
ATOM   96   C CB  . VAL   A 1 13  ? -11.386 -37.929 18.311  1.000 43.634  0 13  VAL   A CB  1 ? 
ATOM   97   C CG1 . VAL   A 1 13  ? -11.604 -37.522 16.862  1.000 42.907  0 13  VAL   A CG1 1 ? 
ATOM   98   C CG2 . VAL   A 1 13  ? -12.613 -37.618 19.162  1.000 45.428  0 13  VAL   A CG2 1 ? 
ATOM   99   N N   . GLU   A 1 14  ? -8.673  -39.711 17.621  1.000 36.908  0 14  GLU   A N   1 ? 
ATOM   100  C CA  . GLU   A 1 14  ? -7.644  -40.205 16.712  1.000 38.939  0 14  GLU   A CA  1 ? 
ATOM   101  C C   . GLU   A 1 14  ? -7.997  -41.598 16.163  1.000 40.896  0 14  GLU   A C   1 ? 
ATOM   102  O O   . GLU   A 1 14  ? -7.969  -41.847 14.954  1.000 38.891  0 14  GLU   A O   1 ? 
ATOM   103  C CB  . GLU   A 1 14  ? -6.282  -40.245 17.418  1.000 40.057  0 14  GLU   A CB  1 ? 
ATOM   104  C CG  . GLU   A 1 14  ? -5.737  -38.875 17.789  1.000 42.453  0 14  GLU   A CG  1 ? 
ATOM   105  C CD  . GLU   A 1 14  ? -4.457  -38.858 18.618  1.000 45.821  0 14  GLU   A CD  1 ? 
ATOM   106  O OE1 . GLU   A 1 14  ? -3.497  -39.602 18.292  1.000 42.657  0 14  GLU   A OE1 1 ? 
ATOM   107  O OE2 . GLU   A 1 14  ? -4.410  -38.076 19.583  1.000 48.351  0 14  GLU   A OE2 1 ? 
ATOM   108  N N   . GLY   A 1 15  ? -8.346  -42.527 17.057  1.000 43.559  0 15  GLY   A N   1 ? 
ATOM   109  C CA  . GLY   A 1 15  ? -8.609  -43.900 16.658  1.000 45.264  0 15  GLY   A CA  1 ? 
ATOM   110  C C   . GLY   A 1 15  ? -9.946  -44.088 15.941  1.000 41.943  0 15  GLY   A C   1 ? 
ATOM   111  O O   . GLY   A 1 15  ? -10.331 -45.219 15.663  1.000 41.374  0 15  GLY   A O   1 ? 
ATOM   112  N N   . CYS   A 1 16  ? -10.646 -42.989 15.651  1.000 40.763  0 16  CYS   A N   1 ? 
ATOM   113  C CA  . CYS   A 1 16  ? -11.869 -43.029 14.865  1.000 43.606  0 16  CYS   A CA  1 ? 
ATOM   114  C C   . CYS   A 1 16  ? -11.700 -42.328 13.517  1.000 41.847  0 16  CYS   A C   1 ? 
ATOM   115  O O   . CYS   A 1 16  ? -12.657 -42.227 12.752  1.000 42.052  0 16  CYS   A O   1 ? 
ATOM   116  C CB  . CYS   A 1 16  ? -13.003 -42.365 15.629  1.000 47.221  0 16  CYS   A CB  1 ? 
ATOM   117  S SG  . CYS   A 1 16  ? -13.448 -43.252 17.143  1.000 51.557  0 16  CYS   A SG  1 ? 
ATOM   118  N N   . MET   A 1 17  ? -10.485 -41.856 13.221  1.000 39.591  0 17  MET   A N   1 ? 
ATOM   119  C CA  . MET   A 1 17  ? -10.263 -41.102 12.003  1.000 41.567  0 17  MET   A CA  1 ? 
ATOM   120  C C   . MET   A 1 17  ? -9.738  -42.041 10.915  1.000 43.641  0 17  MET   A C   1 ? 
ATOM   121  O O   . MET   A 1 17  ? -8.841  -42.840 11.170  1.000 43.094  0 17  MET   A O   1 ? 
ATOM   122  C CB  . MET   A 1 17  ? -9.261  -39.975 12.261  1.000 41.557  0 17  MET   A CB  1 ? 
ATOM   123  C CG  . MET   A 1 17  ? -9.742  -38.972 13.287  1.000 40.289  0 17  MET   A CG  1 ? 
ATOM   124  S SD  . MET   A 1 17  ? -11.423 -38.349 12.992  1.000 41.602  0 17  MET   A SD  1 ? 
ATOM   125  C CE  . MET   A 1 17  ? -11.206 -37.566 11.391  1.000 45.187  0 17  MET   A CE  1 ? 
ATOM   126  N N   . VAL   A 1 18  ? -10.316 -41.930 9.707   1.000 42.957  0 18  VAL   A N   1 ? 
ATOM   127  C CA  . VAL   A 1 18  ? -9.957  -42.755 8.561   1.000 37.139  0 18  VAL   A CA  1 ? 
ATOM   128  C C   . VAL   A 1 18  ? -9.909  -41.889 7.307   1.000 37.388  0 18  VAL   A C   1 ? 
ATOM   129  O O   . VAL   A 1 18  ? -10.463 -40.797 7.274   1.000 41.983  0 18  VAL   A O   1 ? 
ATOM   130  C CB  . VAL   A 1 18  ? -10.974 -43.885 8.356   1.000 35.357  0 18  VAL   A CB  1 ? 
ATOM   131  C CG1 . VAL   A 1 18  ? -10.897 -44.930 9.443   1.000 35.316  0 18  VAL   A CG1 1 ? 
ATOM   132  C CG2 . VAL   A 1 18  ? -12.385 -43.343 8.251   1.000 36.718  0 18  VAL   A CG2 1 ? 
ATOM   133  N N   . GLN   A 1 19  ? -9.274  -42.419 6.262   1.000 38.146  0 19  GLN   A N   1 ? 
ATOM   134  C CA  . GLN   A 1 19  ? -9.206  -41.762 4.970   1.000 39.662  0 19  GLN   A CA  1 ? 
ATOM   135  C C   . GLN   A 1 19  ? -10.291 -42.350 4.077   1.000 37.295  0 19  GLN   A C   1 ? 
ATOM   136  O O   . GLN   A 1 19  ? -10.531 -43.553 4.116   1.000 39.325  0 19  GLN   A O   1 ? 
ATOM   137  C CB  . GLN   A 1 19  ? -7.820  -41.974 4.363   1.000 43.963  0 19  GLN   A CB  1 ? 
ATOM   138  C CG  . GLN   A 1 19  ? -7.609  -41.294 3.014   1.000 47.716  0 19  GLN   A CG  1 ? 
ATOM   139  C CD  . GLN   A 1 19  ? -6.495  -41.972 2.250   1.000 51.291  0 19  GLN   A CD  1 ? 
ATOM   140  O OE1 . GLN   A 1 19  ? -6.710  -42.962 1.550   1.000 58.178  0 19  GLN   A OE1 1 ? 
ATOM   141  N NE2 . GLN   A 1 19  ? -5.288  -41.450 2.386   1.000 49.318  0 19  GLN   A NE2 1 ? 
ATOM   142  N N   . VAL   A 1 20  ? -10.931 -41.490 3.280   1.000 36.410  0 20  VAL   A N   1 ? 
ATOM   143  C CA  . VAL   A 1 20  ? -11.988 -41.901 2.373   1.000 37.098  0 20  VAL   A CA  1 ? 
ATOM   144  C C   . VAL   A 1 20  ? -11.703 -41.315 1.001   1.000 39.646  0 20  VAL   A C   1 ? 
ATOM   145  O O   . VAL   A 1 20  ? -11.699 -40.097 0.864   1.000 40.073  0 20  VAL   A O   1 ? 
ATOM   146  C CB  . VAL   A 1 20  ? -13.376 -41.427 2.838   1.000 36.869  0 20  VAL   A CB  1 ? 
ATOM   147  C CG1 . VAL   A 1 20  ? -14.476 -41.924 1.910   1.000 34.227  0 20  VAL   A CG1 1 ? 
ATOM   148  C CG2 . VAL   A 1 20  ? -13.664 -41.811 4.277   1.000 37.056  0 20  VAL   A CG2 1 ? 
ATOM   149  N N   . THR   A 1 21  ? -11.532 -42.190 0.000   1.000 43.312  0 21  THR   A N   1 ? 
ATOM   150  C CA  . THR   A 1 21  ? -11.363 -41.774 -1.383  1.000 43.942  0 21  THR   A CA  1 ? 
ATOM   151  C C   . THR   A 1 21  ? -12.596 -42.168 -2.195  1.000 44.958  0 21  THR   A C   1 ? 
ATOM   152  O O   . THR   A 1 21  ? -13.112 -43.274 -2.044  1.000 50.380  0 21  THR   A O   1 ? 
ATOM   153  C CB  . THR   A 1 21  ? -10.110 -42.405 -2.000  1.000 44.914  0 21  THR   A CB  1 ? 
ATOM   154  O OG1 . THR   A 1 21  ? -8.959  -42.079 -1.221  1.000 44.346  0 21  THR   A OG1 1 ? 
ATOM   155  C CG2 . THR   A 1 21  ? -9.883  -41.950 -3.424  1.000 47.944  0 21  THR   A CG2 1 ? 
ATOM   156  N N   . CYS   A 1 22  ? -13.060 -41.244 -3.046  1.000 44.574  0 22  CYS   A N   1 ? 
ATOM   157  C CA  . CYS   A 1 22  ? -14.012 -41.547 -4.107  1.000 45.799  0 22  CYS   A CA  1 ? 
ATOM   158  C C   . CYS   A 1 22  ? -13.715 -40.629 -5.289  1.000 45.399  0 22  CYS   A C   1 ? 
ATOM   159  O O   . CYS   A 1 22  ? -13.380 -39.454 -5.125  1.000 47.398  0 22  CYS   A O   1 ? 
ATOM   160  C CB  . CYS   A 1 22  ? -15.459 -41.420 -3.636  1.000 46.588  0 22  CYS   A CB  1 ? 
ATOM   161  S SG  . CYS   A 1 22  ? -16.694 -41.674 -4.943  1.000 51.089  0 22  CYS   A SG  1 ? 
ATOM   162  N N   . GLY   A 1 23  ? -13.808 -41.181 -6.494  1.000 45.987  0 23  GLY   A N   1 ? 
ATOM   163  C CA  . GLY   A 1 23  ? -13.148 -40.554 -7.623  1.000 51.341  0 23  GLY   A CA  1 ? 
ATOM   164  C C   . GLY   A 1 23  ? -11.673 -40.329 -7.296  1.000 52.376  0 23  GLY   A C   1 ? 
ATOM   165  O O   . GLY   A 1 23  ? -11.006 -41.222 -6.785  1.000 48.997  0 23  GLY   A O   1 ? 
ATOM   166  N N   . THR   A 1 24  ? -11.189 -39.119 -7.571  1.000 57.324  0 24  THR   A N   1 ? 
ATOM   167  C CA  . THR   A 1 24  ? -9.861  -38.700 -7.163  1.000 61.782  0 24  THR   A CA  1 ? 
ATOM   168  C C   . THR   A 1 24  ? -9.901  -38.223 -5.714  1.000 63.836  0 24  THR   A C   1 ? 
ATOM   169  O O   . THR   A 1 24  ? -9.077  -38.635 -4.899  1.000 72.879  0 24  THR   A O   1 ? 
ATOM   170  C CB  . THR   A 1 24  ? -9.361  -37.570 -8.068  1.000 67.592  0 24  THR   A CB  1 ? 
ATOM   171  O OG1 . THR   A 1 24  ? -10.408 -36.597 -8.121  1.000 65.315  0 24  THR   A OG1 1 ? 
ATOM   172  C CG2 . THR   A 1 24  ? -9.010  -38.049 -9.460  1.000 70.116  0 24  THR   A CG2 1 ? 
ATOM   173  N N   . THR   A 1 25  ? -10.879 -37.352 -5.430  1.000 59.771  0 25  THR   A N   1 ? 
ATOM   174  C CA  . THR   A 1 25  ? -10.997 -36.633 -4.165  1.000 53.256  0 25  THR   A CA  1 ? 
ATOM   175  C C   . THR   A 1 25  ? -10.860 -37.599 -2.986  1.000 48.052  0 25  THR   A C   1 ? 
ATOM   176  O O   . THR   A 1 25  ? -11.655 -38.524 -2.844  1.000 46.336  0 25  THR   A O   1 ? 
ATOM   177  C CB  . THR   A 1 25  ? -12.340 -35.894 -4.056  1.000 47.767  0 25  THR   A CB  1 ? 
ATOM   178  O OG1 . THR   A 1 25  ? -13.222 -36.698 -3.277  1.000 45.858  0 25  THR   A OG1 1 ? 
ATOM   179  C CG2 . THR   A 1 25  ? -13.001 -35.591 -5.385  1.000 47.017  0 25  THR   A CG2 1 ? 
ATOM   180  N N   . THR   A 1 26  ? -9.828  -37.399 -2.159  1.000 45.772  0 26  THR   A N   1 ? 
ATOM   181  C CA  . THR   A 1 26  ? -9.730  -38.101 -0.888  1.000 44.496  0 26  THR   A CA  1 ? 
ATOM   182  C C   . THR   A 1 26  ? -9.857  -37.079 0.243   1.000 42.874  0 26  THR   A C   1 ? 
ATOM   183  O O   . THR   A 1 26  ? -9.344  -35.970 0.126   1.000 44.854  0 26  THR   A O   1 ? 
ATOM   184  C CB  . THR   A 1 26  ? -8.435  -38.916 -0.766  1.000 44.430  0 26  THR   A CB  1 ? 
ATOM   185  O OG1 . THR   A 1 26  ? -7.495  -38.137 -0.034  1.000 46.120  0 26  THR   A OG1 1 ? 
ATOM   186  C CG2 . THR   A 1 26  ? -7.830  -39.327 -2.090  1.000 44.975  0 26  THR   A CG2 1 ? 
ATOM   187  N N   . LEU   A 1 27  ? -10.556 -37.458 1.325   1.000 41.585  0 27  LEU   A N   1 ? 
ATOM   188  C CA  . LEU   A 1 27  ? -10.677 -36.634 2.520   1.000 38.004  0 27  LEU   A CA  1 ? 
ATOM   189  C C   . LEU   A 1 27  ? -10.738 -37.536 3.748   1.000 37.086  0 27  LEU   A C   1 ? 
ATOM   190  O O   . LEU   A 1 27  ? -10.429 -38.716 3.648   1.000 35.844  0 27  LEU   A O   1 ? 
ATOM   191  C CB  . LEU   A 1 27  ? -11.918 -35.751 2.383   1.000 36.142  0 27  LEU   A CB  1 ? 
ATOM   192  C CG  . LEU   A 1 27  ? -13.142 -36.412 1.754   1.000 37.664  0 27  LEU   A CG  1 ? 
ATOM   193  C CD1 . LEU   A 1 27  ? -13.671 -37.550 2.616   1.000 37.910  0 27  LEU   A CD1 1 ? 
ATOM   194  C CD2 . LEU   A 1 27  ? -14.230 -35.374 1.531   1.000 38.063  0 27  LEU   A CD2 1 ? 
ATOM   195  N N   . ASN   A 1 28  ? -11.123 -36.969 4.901   1.000 41.224  0 28  ASN   A N   1 ? 
ATOM   196  C CA  . ASN   A 1 28  ? -11.184 -37.695 6.165   1.000 37.657  0 28  ASN   A CA  1 ? 
ATOM   197  C C   . ASN   A 1 28  ? -12.604 -38.180 6.444   1.000 33.902  0 28  ASN   A C   1 ? 
ATOM   198  O O   . ASN   A 1 28  ? -13.581 -37.536 6.077   1.000 29.590  0 28  ASN   A O   1 ? 
ATOM   199  C CB  . ASN   A 1 28  ? -10.719 -36.827 7.334   1.000 37.443  0 28  ASN   A CB  1 ? 
ATOM   200  C CG  . ASN   A 1 28  ? -9.331  -36.263 7.129   1.000 39.304  0 28  ASN   A CG  1 ? 
ATOM   201  O OD1 . ASN   A 1 28  ? -8.362  -37.017 7.113   1.000 40.284  0 28  ASN   A OD1 1 ? 
ATOM   202  N ND2 . ASN   A 1 28  ? -9.226  -34.951 6.975   1.000 37.494  0 28  ASN   A ND2 1 ? 
ATOM   203  N N   . GLY   A 1 29  ? -12.695 -39.309 7.147   1.000 35.333  0 29  GLY   A N   1 ? 
ATOM   204  C CA  . GLY   A 1 29  ? -13.970 -39.844 7.602   1.000 36.846  0 29  GLY   A CA  1 ? 
ATOM   205  C C   . GLY   A 1 29  ? -13.876 -40.328 9.045   1.000 34.717  0 29  GLY   A C   1 ? 
ATOM   206  O O   . GLY   A 1 29  ? -12.782 -40.459 9.589   1.000 33.483  0 29  GLY   A O   1 ? 
ATOM   207  N N   . LEU   A 1 30  ? -15.029 -40.589 9.662   1.000 34.771  0 30  LEU   A N   1 ? 
ATOM   208  C CA  . LEU   A 1 30  ? -15.044 -40.947 11.072  1.000 36.958  0 30  LEU   A CA  1 ? 
ATOM   209  C C   . LEU   A 1 30  ? -15.713 -42.301 11.245  1.000 40.941  0 30  LEU   A C   1 ? 
ATOM   210  O O   . LEU   A 1 30  ? -16.847 -42.505 10.822  1.000 45.082  0 30  LEU   A O   1 ? 
ATOM   211  C CB  . LEU   A 1 30  ? -15.789 -39.871 11.862  1.000 36.493  0 30  LEU   A CB  1 ? 
ATOM   212  C CG  . LEU   A 1 30  ? -15.877 -40.107 13.368  1.000 34.968  0 30  LEU   A CG  1 ? 
ATOM   213  C CD1 . LEU   A 1 30  ? -14.562 -39.733 14.036  1.000 36.578  0 30  LEU   A CD1 1 ? 
ATOM   214  C CD2 . LEU   A 1 30  ? -17.040 -39.333 13.972  1.000 32.140  0 30  LEU   A CD2 1 ? 
ATOM   215  N N   . TRP   A 1 31  ? -15.000 -43.209 11.905  1.000 43.724  0 31  TRP   A N   1 ? 
ATOM   216  C CA  . TRP   A 1 31  ? -15.368 -44.612 11.906  1.000 43.559  0 31  TRP   A CA  1 ? 
ATOM   217  C C   . TRP   A 1 31  ? -15.829 -45.009 13.302  1.000 43.114  0 31  TRP   A C   1 ? 
ATOM   218  O O   . TRP   A 1 31  ? -15.020 -45.133 14.218  1.000 43.716  0 31  TRP   A O   1 ? 
ATOM   219  C CB  . TRP   A 1 31  ? -14.171 -45.451 11.449  1.000 43.581  0 31  TRP   A CB  1 ? 
ATOM   220  C CG  . TRP   A 1 31  ? -14.413 -46.932 11.466  1.000 43.362  0 31  TRP   A CG  1 ? 
ATOM   221  C CD1 . TRP   A 1 31  ? -15.603 -47.598 11.438  1.000 44.237  0 31  TRP   A CD1 1 ? 
ATOM   222  C CD2 . TRP   A 1 31  ? -13.389 -47.937 11.565  1.000 44.520  0 31  TRP   A CD2 1 ? 
ATOM   223  N NE1 . TRP   A 1 31  ? -15.392 -48.951 11.488  1.000 44.940  0 31  TRP   A NE1 1 ? 
ATOM   224  C CE2 . TRP   A 1 31  ? -14.044 -49.188 11.570  1.000 44.856  0 31  TRP   A CE2 1 ? 
ATOM   225  C CE3 . TRP   A 1 31  ? -11.993 -47.893 11.647  1.000 45.820  0 31  TRP   A CE3 1 ? 
ATOM   226  C CZ2 . TRP   A 1 31  ? -13.342 -50.386 11.662  1.000 47.013  0 31  TRP   A CZ2 1 ? 
ATOM   227  C CZ3 . TRP   A 1 31  ? -11.302 -49.079 11.739  1.000 47.336  0 31  TRP   A CZ3 1 ? 
ATOM   228  C CH2 . TRP   A 1 31  ? -11.969 -50.306 11.753  1.000 47.648  0 31  TRP   A CH2 1 ? 
ATOM   229  N N   . LEU   A 1 32  ? -17.141 -45.194 13.441  1.000 41.435  0 32  LEU   A N   1 ? 
ATOM   230  C CA  . LEU   A 1 32  ? -17.729 -45.584 14.706  1.000 45.393  0 32  LEU   A CA  1 ? 
ATOM   231  C C   . LEU   A 1 32  ? -18.541 -46.853 14.497  1.000 48.664  0 32  LEU   A C   1 ? 
ATOM   232  O O   . LEU   A 1 32  ? -19.485 -46.861 13.705  1.000 45.983  0 32  LEU   A O   1 ? 
ATOM   233  C CB  . LEU   A 1 32  ? -18.630 -44.455 15.210  1.000 45.561  0 32  LEU   A CB  1 ? 
ATOM   234  C CG  . LEU   A 1 32  ? -17.960 -43.095 15.370  1.000 43.885  0 32  LEU   A CG  1 ? 
ATOM   235  C CD1 . LEU   A 1 32  ? -18.999 -42.042 15.722  1.000 43.355  0 32  LEU   A CD1 1 ? 
ATOM   236  C CD2 . LEU   A 1 32  ? -16.853 -43.141 16.421  1.000 43.063  0 32  LEU   A CD2 1 ? 
ATOM   237  N N   . ASP   A 1 33  ? -18.177 -47.894 15.257  1.000 52.771  0 33  ASP   A N   1 ? 
ATOM   238  C CA  . ASP   A 1 33  ? -18.781 -49.202 15.100  1.000 54.248  0 33  ASP   A CA  1 ? 
ATOM   239  C C   . ASP   A 1 33  ? -18.541 -49.589 13.647  1.000 52.168  0 33  ASP   A C   1 ? 
ATOM   240  O O   . ASP   A 1 33  ? -17.423 -49.403 13.162  1.000 49.000  0 33  ASP   A O   1 ? 
ATOM   241  C CB  . ASP   A 1 33  ? -20.236 -49.177 15.577  1.000 55.590  0 33  ASP   A CB  1 ? 
ATOM   242  C CG  . ASP   A 1 33  ? -20.370 -48.677 17.009  1.000 59.625  0 33  ASP   A CG  1 ? 
ATOM   243  O OD1 . ASP   A 1 33  ? -19.577 -49.147 17.870  1.000 64.054  0 33  ASP   A OD1 1 ? 
ATOM   244  O OD2 . ASP   A 1 33  ? -21.267 -47.836 17.263  1.000 53.217  0 33  ASP   A OD2 1 ? 
ATOM   245  N N   . ASP   A 1 34  ? -19.588 -50.060 12.956  1.000 50.126  0 34  ASP   A N   1 ? 
ATOM   246  C CA  . ASP   A 1 34  ? -19.443 -50.498 11.577  1.000 48.314  0 34  ASP   A CA  1 ? 
ATOM   247  C C   . ASP   A 1 34  ? -19.996 -49.437 10.626  1.000 47.795  0 34  ASP   A C   1 ? 
ATOM   248  O O   . ASP   A 1 34  ? -20.686 -49.793 9.674   1.000 49.257  0 34  ASP   A O   1 ? 
ATOM   249  C CB  . ASP   A 1 34  ? -20.132 -51.850 11.349  1.000 47.604  0 34  ASP   A CB  1 ? 
ATOM   250  C CG  . ASP   A 1 34  ? -21.652 -51.828 11.424  1.000 45.326  0 34  ASP   A CG  1 ? 
ATOM   251  O OD1 . ASP   A 1 34  ? -22.203 -50.977 12.141  1.000 43.900  0 34  ASP   A OD1 1 ? 
ATOM   252  O OD2 . ASP   A 1 34  ? -22.272 -52.634 10.722  1.000 45.709  0 34  ASP   A OD2 1 ? 
ATOM   253  N N   . VAL   A 1 35  ? -19.709 -48.145 10.892  1.000 45.749  0 35  VAL   A N   1 ? 
ATOM   254  C CA  . VAL   A 1 35  ? -20.136 -47.052 10.021  1.000 39.889  0 35  VAL   A CA  1 ? 
ATOM   255  C C   . VAL   A 1 35  ? -19.028 -46.004 9.936   1.000 40.128  0 35  VAL   A C   1 ? 
ATOM   256  O O   . VAL   A 1 35  ? -18.404 -45.673 10.941  1.000 42.842  0 35  VAL   A O   1 ? 
ATOM   257  C CB  . VAL   A 1 35  ? -21.453 -46.398 10.478  1.000 34.720  0 35  VAL   A CB  1 ? 
ATOM   258  C CG1 . VAL   A 1 35  ? -21.862 -45.282 9.528   1.000 33.659  0 35  VAL   A CG1 1 ? 
ATOM   259  C CG2 . VAL   A 1 35  ? -22.581 -47.401 10.641  1.000 32.843  0 35  VAL   A CG2 1 ? 
ATOM   260  N N   . VAL   A 1 36  ? -18.788 -45.495 8.718   1.000 40.024  0 36  VAL   A N   1 ? 
ATOM   261  C CA  . VAL   A 1 36  ? -17.829 -44.425 8.504   1.000 38.060  0 36  VAL   A CA  1 ? 
ATOM   262  C C   . VAL   A 1 36  ? -18.584 -43.235 7.948   1.000 39.240  0 36  VAL   A C   1 ? 
ATOM   263  O O   . VAL   A 1 36  ? -19.249 -43.349 6.931   1.000 40.363  0 36  VAL   A O   1 ? 
ATOM   264  C CB  . VAL   A 1 36  ? -16.694 -44.809 7.549   1.000 36.161  0 36  VAL   A CB  1 ? 
ATOM   265  C CG1 . VAL   A 1 36  ? -15.806 -43.617 7.243   1.000 35.808  0 36  VAL   A CG1 1 ? 
ATOM   266  C CG2 . VAL   A 1 36  ? -15.870 -45.941 8.116   1.000 38.925  0 36  VAL   A CG2 1 ? 
ATOM   267  N N   . TYR   A 1 37  ? -18.470 -42.106 8.645   1.000 42.910  0 37  TYR   A N   1 ? 
ATOM   268  C CA  . TYR   A 1 37  ? -19.189 -40.901 8.283   1.000 40.391  0 37  TYR   A CA  1 ? 
ATOM   269  C C   . TYR   A 1 37  ? -18.210 -39.984 7.559   1.000 38.959  0 37  TYR   A C   1 ? 
ATOM   270  O O   . TYR   A 1 37  ? -17.030 -39.919 7.935   1.000 36.913  0 37  TYR   A O   1 ? 
ATOM   271  C CB  . TYR   A 1 37  ? -19.782 -40.261 9.544   1.000 38.766  0 37  TYR   A CB  1 ? 
ATOM   272  C CG  . TYR   A 1 37  ? -20.722 -41.131 10.369  1.000 38.681  0 37  TYR   A CG  1 ? 
ATOM   273  C CD1 . TYR   A 1 37  ? -20.242 -42.131 11.214  1.000 38.845  0 37  TYR   A CD1 1 ? 
ATOM   274  C CD2 . TYR   A 1 37  ? -22.098 -40.928 10.323  1.000 39.737  0 37  TYR   A CD2 1 ? 
ATOM   275  C CE1 . TYR   A 1 37  ? -21.101 -42.912 11.970  1.000 39.427  0 37  TYR   A CE1 1 ? 
ATOM   276  C CE2 . TYR   A 1 37  ? -22.969 -41.706 11.071  1.000 40.614  0 37  TYR   A CE2 1 ? 
ATOM   277  C CZ  . TYR   A 1 37  ? -22.470 -42.703 11.890  1.000 42.949  0 37  TYR   A CZ  1 ? 
ATOM   278  O OH  . TYR   A 1 37  ? -23.349 -43.456 12.616  1.000 50.007  0 37  TYR   A OH  1 ? 
ATOM   279  N N   . CYS   A 1 38  ? -18.713 -39.284 6.532   1.000 36.870  0 38  CYS   A N   1 ? 
ATOM   280  C CA  . CYS   A 1 38  ? -17.921 -38.260 5.878   1.000 35.478  0 38  CYS   A CA  1 ? 
ATOM   281  C C   . CYS   A 1 38  ? -18.810 -37.282 5.115   1.000 34.938  0 38  CYS   A C   1 ? 
ATOM   282  O O   . CYS   A 1 38  ? -19.989 -37.547 4.875   1.000 33.739  0 38  CYS   A O   1 ? 
ATOM   283  C CB  . CYS   A 1 38  ? -16.910 -38.901 4.944   1.000 37.934  0 38  CYS   A CB  1 ? 
ATOM   284  S SG  . CYS   A 1 38  ? -17.696 -39.675 3.509   1.000 43.828  0 38  CYS   A SG  1 ? 
ATOM   285  N N   . PRO   A 1 39  ? -18.252 -36.120 4.699   1.000 36.415  0 39  PRO   A N   1 ? 
ATOM   286  C CA  . PRO   A 1 39  ? -19.002 -35.160 3.896   1.000 36.312  0 39  PRO   A CA  1 ? 
ATOM   287  C C   . PRO   A 1 39  ? -19.332 -35.788 2.544   1.000 39.476  0 39  PRO   A C   1 ? 
ATOM   288  O O   . PRO   A 1 39  ? -18.466 -36.391 1.917   1.000 39.113  0 39  PRO   A O   1 ? 
ATOM   289  C CB  . PRO   A 1 39  ? -18.051 -33.962 3.714   1.000 36.915  0 39  PRO   A CB  1 ? 
ATOM   290  C CG  . PRO   A 1 39  ? -16.860 -34.211 4.648   1.000 36.327  0 39  PRO   A CG  1 ? 
ATOM   291  C CD  . PRO   A 1 39  ? -16.854 -35.696 4.929   1.000 36.278  0 39  PRO   A CD  1 ? 
ATOM   292  N N   . ARG   A 1 40  ? -20.574 -35.607 2.079   1.000 41.584  0 40  ARG   A N   1 ? 
ATOM   293  C CA  . ARG   A 1 40  ? -21.033 -36.236 0.851   1.000 40.314  0 40  ARG   A CA  1 ? 
ATOM   294  C C   . ARG   A 1 40  ? -20.291 -35.691 -0.370  1.000 42.188  0 40  ARG   A C   1 ? 
ATOM   295  O O   . ARG   A 1 40  ? -20.327 -36.325 -1.423  1.000 39.027  0 40  ARG   A O   1 ? 
ATOM   296  C CB  . ARG   A 1 40  ? -22.549 -36.064 0.696   1.000 41.174  0 40  ARG   A CB  1 ? 
ATOM   297  C CG  . ARG   A 1 40  ? -23.034 -34.626 0.583   1.000 39.765  0 40  ARG   A CG  1 ? 
ATOM   298  C CD  . ARG   A 1 40  ? -24.533 -34.560 0.380   1.000 37.509  0 40  ARG   A CD  1 ? 
ATOM   299  N NE  . ARG   A 1 40  ? -24.980 -33.179 0.279   1.000 38.565  0 40  ARG   A NE  1 ? 
ATOM   300  C CZ  . ARG   A 1 40  ? -26.210 -32.799 -0.061  1.000 35.831  0 40  ARG   A CZ  1 ? 
ATOM   301  N NH1 . ARG   A 1 40  ? -27.163 -33.699 -0.223  1.000 36.222  0 40  ARG   A NH1 1 ? 
ATOM   302  N NH2 . ARG   A 1 40  ? -26.478 -31.519 -0.246  1.000 32.793  0 40  ARG   A NH2 1 ? 
ATOM   303  N N   . HIS   A 1 41  ? -19.599 -34.546 -0.229  1.000 43.991  0 41  HIS   A N   1 ? 
ATOM   304  C CA  . HIS   A 1 41  ? -18.974 -33.879 -1.366  1.000 48.543  0 41  HIS   A CA  1 ? 
ATOM   305  C C   . HIS   A 1 41  ? -17.702 -34.610 -1.809  1.000 50.110  0 41  HIS   A C   1 ? 
ATOM   306  O O   . HIS   A 1 41  ? -16.925 -34.093 -2.617  1.000 53.811  0 41  HIS   A O   1 ? 
ATOM   307  C CB  . HIS   A 1 41  ? -18.776 -32.377 -1.095  1.000 49.838  0 41  HIS   A CB  1 ? 
ATOM   308  C CG  . HIS   A 1 41  ? -17.637 -31.985 -0.202  1.000 54.140  0 41  HIS   A CG  1 ? 
ATOM   309  N ND1 . HIS   A 1 41  ? -17.841 -31.448 1.053   1.000 52.712  0 41  HIS   A ND1 1 ? 
ATOM   310  C CD2 . HIS   A 1 41  ? -16.295 -32.009 -0.386  1.000 55.123  0 41  HIS   A CD2 1 ? 
ATOM   311  C CE1 . HIS   A 1 41  ? -16.660 -31.178 1.603   1.000 57.721  0 41  HIS   A CE1 1 ? 
ATOM   312  N NE2 . HIS   A 1 41  ? -15.705 -31.514 0.748   1.000 55.980  0 41  HIS   A NE2 1 ? 
ATOM   313  N N   . VAL   A 1 42  ? -17.510 -35.829 -1.301  1.000 47.503  0 42  VAL   A N   1 ? 
ATOM   314  C CA  . VAL   A 1 42  ? -16.387 -36.672 -1.685  1.000 46.886  0 42  VAL   A CA  1 ? 
ATOM   315  C C   . VAL   A 1 42  ? -16.609 -37.258 -3.089  1.000 45.787  0 42  VAL   A C   1 ? 
ATOM   316  O O   . VAL   A 1 42  ? -15.649 -37.592 -3.793  1.000 38.523  0 42  VAL   A O   1 ? 
ATOM   317  C CB  . VAL   A 1 42  ? -16.192 -37.755 -0.604  1.000 41.415  0 42  VAL   A CB  1 ? 
ATOM   318  C CG1 . VAL   A 1 42  ? -17.358 -38.736 -0.552  1.000 37.295  0 42  VAL   A CG1 1 ? 
ATOM   319  C CG2 . VAL   A 1 42  ? -14.863 -38.471 -0.772  1.000 42.308  0 42  VAL   A CG2 1 ? 
ATOM   320  N N   . ILE   A 1 43  ? -17.894 -37.346 -3.479  1.000 48.602  0 43  ILE   A N   1 ? 
ATOM   321  C CA  . ILE   A 1 43  ? -18.337 -37.886 -4.757  1.000 50.870  0 43  ILE   A CA  1 ? 
ATOM   322  C C   . ILE   A 1 43  ? -18.267 -36.831 -5.863  1.000 53.552  0 43  ILE   A C   1 ? 
ATOM   323  O O   . ILE   A 1 43  ? -18.608 -37.136 -7.006  1.000 59.222  0 43  ILE   A O   1 ? 
ATOM   324  C CB  . ILE   A 1 43  ? -19.780 -38.428 -4.657  1.000 49.711  0 43  ILE   A CB  1 ? 
ATOM   325  C CG1 . ILE   A 1 43  ? -20.823 -37.307 -4.583  1.000 47.385  0 43  ILE   A CG1 1 ? 
ATOM   326  C CG2 . ILE   A 1 43  ? -19.917 -39.404 -3.501  1.000 51.411  0 43  ILE   A CG2 1 ? 
ATOM   327  C CD1 . ILE   A 1 43  ? -22.248 -37.797 -4.589  1.000 46.842  0 43  ILE   A CD1 1 ? 
ATOM   328  N N   . CYS   A 1 44  ? -17.887 -35.592 -5.529  1.000 50.364  0 44  CYS   A N   1 ? 
ATOM   329  C CA  . CYS   A 1 44  ? -17.888 -34.518 -6.506  1.000 52.179  0 44  CYS   A CA  1 ? 
ATOM   330  C C   . CYS   A 1 44  ? -16.487 -34.295 -7.068  1.000 54.472  0 44  CYS   A C   1 ? 
ATOM   331  O O   . CYS   A 1 44  ? -15.486 -34.531 -6.391  1.000 56.129  0 44  CYS   A O   1 ? 
ATOM   332  C CB  . CYS   A 1 44  ? -18.378 -33.214 -5.895  1.000 53.377  0 44  CYS   A CB  1 ? 
ATOM   333  S SG  . CYS   A 1 44  ? -20.136 -33.230 -5.476  1.000 58.492  0 44  CYS   A SG  1 ? 
ATOM   334  N N   . THR   A 1 45  ? -16.455 -33.829 -8.322  1.000 55.074  0 45  THR   A N   1 ? 
ATOM   335  C CA  . THR   A 1 45  ? -15.264 -33.292 -8.959  1.000 54.446  0 45  THR   A CA  1 ? 
ATOM   336  C C   . THR   A 1 45  ? -15.254 -31.775 -8.812  1.000 55.841  0 45  THR   A C   1 ? 
ATOM   337  O O   . THR   A 1 45  ? -16.282 -31.185 -8.495  1.000 56.099  0 45  THR   A O   1 ? 
ATOM   338  C CB  . THR   A 1 45  ? -15.269 -33.641 -10.447 1.000 53.655  0 45  THR   A CB  1 ? 
ATOM   339  O OG1 . THR   A 1 45  ? -16.407 -32.969 -10.993 1.000 53.075  0 45  THR   A OG1 1 ? 
ATOM   340  C CG2 . THR   A 1 45  ? -15.350 -35.132 -10.703 1.000 53.830  0 45  THR   A CG2 1 ? 
ATOM   341  N N   . SER   A 1 46  ? -14.114 -31.149 -9.125  1.000 59.203  0 46  SER   A N   1 ? 
ATOM   342  C CA  . SER   A 1 46  ? -13.959 -29.707 -8.984  1.000 63.857  0 46  SER   A CA  1 ? 
ATOM   343  C C   . SER   A 1 46  ? -15.007 -28.955 -9.804  1.000 68.488  0 46  SER   A C   1 ? 
ATOM   344  O O   . SER   A 1 46  ? -15.304 -27.794 -9.521  1.000 66.237  0 46  SER   A O   1 ? 
ATOM   345  C CB  . SER   A 1 46  ? -12.571 -29.274 -9.364  1.000 61.983  0 46  SER   A CB  1 ? 
ATOM   346  O OG  . SER   A 1 46  ? -11.611 -29.989 -8.607  1.000 62.832  0 46  SER   A OG  1 ? 
ATOM   347  N N   . GLU   A 1 47  ? -15.553 -29.626 -10.824 1.000 72.166  0 47  GLU   A N   1 ? 
ATOM   348  C CA  . GLU   A 1 47  ? -16.599 -29.054 -11.651 1.000 73.685  0 47  GLU   A CA  1 ? 
ATOM   349  C C   . GLU   A 1 47  ? -17.967 -29.279 -11.020 1.000 64.625  0 47  GLU   A C   1 ? 
ATOM   350  O O   . GLU   A 1 47  ? -18.797 -28.376 -11.033 1.000 60.485  0 47  GLU   A O   1 ? 
ATOM   351  C CB  . GLU   A 1 47  ? -16.569 -29.651 -13.058 1.000 80.762  0 47  GLU   A CB  1 ? 
ATOM   352  C CG  . GLU   A 1 47  ? -17.823 -29.342 -13.860 1.000 85.531  0 47  GLU   A CG  1 ? 
ATOM   353  C CD  . GLU   A 1 47  ? -17.672 -29.318 -15.372 1.000 85.103  0 47  GLU   A CD  1 ? 
ATOM   354  O OE1 . GLU   A 1 47  ? -18.695 -29.530 -16.054 1.000 81.919  0 47  GLU   A OE1 1 ? 
ATOM   355  O OE2 . GLU   A 1 47  ? -16.550 -29.043 -15.868 1.000 85.155  0 47  GLU   A OE2 1 ? 
ATOM   356  N N   . ASP   A 1 48  ? -18.208 -30.495 -10.519 1.000 62.305  0 48  ASP   A N   1 ? 
ATOM   357  C CA  . ASP   A 1 48  ? -19.483 -30.821 -9.896  1.000 68.268  0 48  ASP   A CA  1 ? 
ATOM   358  C C   . ASP   A 1 48  ? -19.811 -29.814 -8.791  1.000 67.909  0 48  ASP   A C   1 ? 
ATOM   359  O O   . ASP   A 1 48  ? -20.982 -29.548 -8.514  1.000 60.408  0 48  ASP   A O   1 ? 
ATOM   360  C CB  . ASP   A 1 48  ? -19.481 -32.231 -9.298  1.000 72.396  0 48  ASP   A CB  1 ? 
ATOM   361  C CG  . ASP   A 1 48  ? -19.377 -33.365 -10.305 1.000 71.582  0 48  ASP   A CG  1 ? 
ATOM   362  O OD1 . ASP   A 1 48  ? -20.064 -33.295 -11.340 1.000 75.811  0 48  ASP   A OD1 1 ? 
ATOM   363  O OD2 . ASP   A 1 48  ? -18.636 -34.332 -10.025 1.000 68.117  0 48  ASP   A OD2 1 ? 
ATOM   364  N N   . MET   A 1 49  ? -18.752 -29.261 -8.180  1.000 65.652  0 49  MET   A N   1 ? 
ATOM   365  C CA  . MET   A 1 49  ? -18.833 -28.387 -7.019  1.000 61.557  0 49  MET   A CA  1 ? 
ATOM   366  C C   . MET   A 1 49  ? -19.752 -27.198 -7.269  1.000 55.604  0 49  MET   A C   1 ? 
ATOM   367  O O   . MET   A 1 49  ? -20.383 -26.704 -6.341  1.000 52.520  0 49  MET   A O   1 ? 
ATOM   368  C CB  . MET   A 1 49  ? -17.444 -27.834 -6.679  1.000 65.362  0 49  MET   A CB  1 ? 
ATOM   369  C CG  . MET   A 1 49  ? -16.477 -28.871 -6.132  1.000 68.575  0 49  MET   A CG  1 ? 
ATOM   370  S SD  . MET   A 1 49  ? -16.653 -29.151 -4.359  1.000 74.133  0 49  MET   A SD  1 ? 
ATOM   371  C CE  . MET   A 1 49  ? -18.144 -30.143 -4.323  1.000 76.189  0 49  MET   A CE  1 ? 
ATOM   372  N N   . LEU   A 1 50  ? -19.774 -26.715 -8.513  1.000 56.157  0 50  LEU   A N   1 ? 
ATOM   373  C CA  . LEU   A 1 50  ? -20.373 -25.431 -8.833  1.000 55.691  0 50  LEU   A CA  1 ? 
ATOM   374  C C   . LEU   A 1 50  ? -21.886 -25.501 -8.680  1.000 53.150  0 50  LEU   A C   1 ? 
ATOM   375  O O   . LEU   A 1 50  ? -22.509 -24.513 -8.310  1.000 50.942  0 50  LEU   A O   1 ? 
ATOM   376  C CB  . LEU   A 1 50  ? -19.950 -25.026 -10.248 1.000 58.427  0 50  LEU   A CB  1 ? 
ATOM   377  C CG  . LEU   A 1 50  ? -18.614 -24.285 -10.350 1.000 64.200  0 50  LEU   A CG  1 ? 
ATOM   378  C CD1 . LEU   A 1 50  ? -17.554 -24.864 -9.420  1.000 67.090  0 50  LEU   A CD1 1 ? 
ATOM   379  C CD2 . LEU   A 1 50  ? -18.100 -24.312 -11.780 1.000 63.895  0 50  LEU   A CD2 1 ? 
ATOM   380  N N   . ASN   A 1 51  ? -22.465 -26.672 -8.945  1.000 56.094  0 51  ASN   A N   1 ? 
ATOM   381  C CA  . ASN   A 1 51  ? -23.877 -26.885 -8.683  1.000 59.129  0 51  ASN   A CA  1 ? 
ATOM   382  C C   . ASN   A 1 51  ? -24.181 -28.373 -8.814  1.000 61.255  0 51  ASN   A C   1 ? 
ATOM   383  O O   . ASN   A 1 51  ? -24.734 -28.823 -9.814  1.000 64.692  0 51  ASN   A O   1 ? 
ATOM   384  C CB  . ASN   A 1 51  ? -24.778 -26.062 -9.607  1.000 59.460  0 51  ASN   A CB  1 ? 
ATOM   385  C CG  . ASN   A 1 51  ? -26.233 -26.120 -9.196  1.000 60.684  0 51  ASN   A CG  1 ? 
ATOM   386  O OD1 . ASN   A 1 51  ? -26.570 -26.615 -8.119  1.000 56.600  0 51  ASN   A OD1 1 ? 
ATOM   387  N ND2 . ASN   A 1 51  ? -27.103 -25.604 -10.048 1.000 63.286  0 51  ASN   A ND2 1 ? 
ATOM   388  N N   . PRO   A 1 52  ? -23.838 -29.182 -7.793  1.000 62.985  0 52  PRO   A N   1 ? 
ATOM   389  C CA  . PRO   A 1 52  ? -24.097 -30.617 -7.836  1.000 62.705  0 52  PRO   A CA  1 ? 
ATOM   390  C C   . PRO   A 1 52  ? -25.541 -30.950 -7.475  1.000 56.999  0 52  PRO   A C   1 ? 
ATOM   391  O O   . PRO   A 1 52  ? -26.139 -30.286 -6.635  1.000 56.325  0 52  PRO   A O   1 ? 
ATOM   392  C CB  . PRO   A 1 52  ? -23.121 -31.163 -6.787  1.000 63.720  0 52  PRO   A CB  1 ? 
ATOM   393  C CG  . PRO   A 1 52  ? -23.022 -30.048 -5.764  1.000 64.899  0 52  PRO   A CG  1 ? 
ATOM   394  C CD  . PRO   A 1 52  ? -23.193 -28.760 -6.543  1.000 65.015  0 52  PRO   A CD  1 ? 
ATOM   395  N N   . ASN   A 1 53  ? -26.089 -31.957 -8.160  1.000 54.211  0 53  ASN   A N   1 ? 
ATOM   396  C CA  . ASN   A 1 53  ? -27.267 -32.671 -7.709  1.000 49.940  0 53  ASN   A CA  1 ? 
ATOM   397  C C   . ASN   A 1 53  ? -26.768 -33.955 -7.057  1.000 48.721  0 53  ASN   A C   1 ? 
ATOM   398  O O   . ASN   A 1 53  ? -26.350 -34.879 -7.748  1.000 49.889  0 53  ASN   A O   1 ? 
ATOM   399  C CB  . ASN   A 1 53  ? -28.237 -32.955 -8.859  1.000 49.284  0 53  ASN   A CB  1 ? 
ATOM   400  C CG  . ASN   A 1 53  ? -29.581 -33.447 -8.370  1.000 52.514  0 53  ASN   A CG  1 ? 
ATOM   401  O OD1 . ASN   A 1 53  ? -29.654 -34.334 -7.524  1.000 56.565  0 53  ASN   A OD1 1 ? 
ATOM   402  N ND2 . ASN   A 1 53  ? -30.657 -32.860 -8.864  1.000 55.387  0 53  ASN   A ND2 1 ? 
ATOM   403  N N   . TYR   A 1 54  ? -26.775 -33.986 -5.724  1.000 49.389  0 54  TYR   A N   1 ? 
ATOM   404  C CA  . TYR   A 1 54  ? -26.087 -35.039 -4.991  1.000 48.290  0 54  TYR   A CA  1 ? 
ATOM   405  C C   . TYR   A 1 54  ? -26.770 -36.383 -5.232  1.000 47.514  0 54  TYR   A C   1 ? 
ATOM   406  O O   . TYR   A 1 54  ? -26.094 -37.393 -5.417  1.000 45.228  0 54  TYR   A O   1 ? 
ATOM   407  C CB  . TYR   A 1 54  ? -26.005 -34.650 -3.512  1.000 45.365  0 54  TYR   A CB  1 ? 
ATOM   408  C CG  . TYR   A 1 54  ? -24.878 -33.677 -3.191  1.000 43.816  0 54  TYR   A CG  1 ? 
ATOM   409  C CD1 . TYR   A 1 54  ? -23.558 -34.112 -3.167  1.000 43.491  0 54  TYR   A CD1 1 ? 
ATOM   410  C CD2 . TYR   A 1 54  ? -25.120 -32.328 -2.923  1.000 41.747  0 54  TYR   A CD2 1 ? 
ATOM   411  C CE1 . TYR   A 1 54  ? -22.515 -33.246 -2.867  1.000 41.667  0 54  TYR   A CE1 1 ? 
ATOM   412  C CE2 . TYR   A 1 54  ? -24.085 -31.456 -2.611  1.000 40.518  0 54  TYR   A CE2 1 ? 
ATOM   413  C CZ  . TYR   A 1 54  ? -22.774 -31.915 -2.583  1.000 40.631  0 54  TYR   A CZ  1 ? 
ATOM   414  O OH  . TYR   A 1 54  ? -21.709 -31.099 -2.306  1.000 36.992  0 54  TYR   A OH  1 ? 
ATOM   415  N N   . GLU   A 1 55  ? -28.107 -36.372 -5.227  1.000 48.866  0 55  GLU   A N   1 ? 
ATOM   416  C CA  . GLU   A 1 55  ? -28.905 -37.560 -5.467  1.000 52.307  0 55  GLU   A CA  1 ? 
ATOM   417  C C   . GLU   A 1 55  ? -28.404 -38.250 -6.727  1.000 53.169  0 55  GLU   A C   1 ? 
ATOM   418  O O   . GLU   A 1 55  ? -28.125 -39.444 -6.717  1.000 57.681  0 55  GLU   A O   1 ? 
ATOM   419  C CB  . GLU   A 1 55  ? -30.381 -37.203 -5.651  1.000 59.474  0 55  GLU   A CB  1 ? 
ATOM   420  C CG  . GLU   A 1 55  ? -31.086 -36.808 -4.363  1.000 66.637  0 55  GLU   A CG  1 ? 
ATOM   421  C CD  . GLU   A 1 55  ? -30.618 -35.529 -3.681  1.000 70.307  0 55  GLU   A CD  1 ? 
ATOM   422  O OE1 . GLU   A 1 55  ? -29.925 -34.705 -4.336  1.000 69.945  0 55  GLU   A OE1 1 ? 
ATOM   423  O OE2 . GLU   A 1 55  ? -30.933 -35.366 -2.480  1.000 73.854  0 55  GLU   A OE2 1 ? 
ATOM   424  N N   . ASP   A 1 56  ? -28.274 -37.461 -7.795  1.000 53.673  0 56  ASP   A N   1 ? 
ATOM   425  C CA  . ASP   A 1 56  ? -27.983 -37.978 -9.119  1.000 56.630  0 56  ASP   A CA  1 ? 
ATOM   426  C C   . ASP   A 1 56  ? -26.496 -38.300 -9.259  1.000 59.185  0 56  ASP   A C   1 ? 
ATOM   427  O O   . ASP   A 1 56  ? -26.135 -39.240 -9.965  1.000 60.607  0 56  ASP   A O   1 ? 
ATOM   428  C CB  . ASP   A 1 56  ? -28.461 -36.993 -10.185 1.000 57.118  0 56  ASP   A CB  1 ? 
ATOM   429  C CG  . ASP   A 1 56  ? -29.974 -36.883 -10.274 1.000 56.904  0 56  ASP   A CG  1 ? 
ATOM   430  O OD1 . ASP   A 1 56  ? -30.680 -37.633 -9.556  1.000 51.426  0 56  ASP   A OD1 1 ? 
ATOM   431  O OD2 . ASP   A 1 56  ? -30.435 -36.039 -11.060 1.000 59.521  0 56  ASP   A OD2 1 ? 
ATOM   432  N N   . LEU   A 1 57  ? -25.636 -37.520 -8.596  1.000 58.970  0 57  LEU   A N   1 ? 
ATOM   433  C CA  . LEU   A 1 57  ? -24.207 -37.804 -8.586  1.000 60.269  0 57  LEU   A CA  1 ? 
ATOM   434  C C   . LEU   A 1 57  ? -23.939 -39.123 -7.868  1.000 64.231  0 57  LEU   A C   1 ? 
ATOM   435  O O   . LEU   A 1 57  ? -22.912 -39.765 -8.112  1.000 61.605  0 57  LEU   A O   1 ? 
ATOM   436  C CB  . LEU   A 1 57  ? -23.451 -36.655 -7.910  1.000 58.373  0 57  LEU   A CB  1 ? 
ATOM   437  C CG  . LEU   A 1 57  ? -22.699 -35.718 -8.851  1.000 55.998  0 57  LEU   A CG  1 ? 
ATOM   438  C CD1 . LEU   A 1 57  ? -22.293 -34.447 -8.134  1.000 55.486  0 57  LEU   A CD1 1 ? 
ATOM   439  C CD2 . LEU   A 1 57  ? -21.467 -36.403 -9.433  1.000 57.485  0 57  LEU   A CD2 1 ? 
ATOM   440  N N   . LEU   A 1 58  ? -24.879 -39.499 -6.986  1.000 68.889  0 58  LEU   A N   1 ? 
ATOM   441  C CA  . LEU   A 1 58  ? -24.709 -40.623 -6.080  1.000 69.743  0 58  LEU   A CA  1 ? 
ATOM   442  C C   . LEU   A 1 58  ? -25.198 -41.924 -6.713  1.000 63.177  0 58  LEU   A C   1 ? 
ATOM   443  O O   . LEU   A 1 58  ? -24.602 -42.967 -6.475  1.000 65.867  0 58  LEU   A O   1 ? 
ATOM   444  C CB  . LEU   A 1 58  ? -25.454 -40.330 -4.772  1.000 67.703  0 58  LEU   A CB  1 ? 
ATOM   445  C CG  . LEU   A 1 58  ? -25.642 -41.519 -3.830  1.000 64.393  0 58  LEU   A CG  1 ? 
ATOM   446  C CD1 . LEU   A 1 58  ? -24.306 -42.121 -3.422  1.000 59.779  0 58  LEU   A CD1 1 ? 
ATOM   447  C CD2 . LEU   A 1 58  ? -26.429 -41.098 -2.600  1.000 65.305  0 58  LEU   A CD2 1 ? 
ATOM   448  N N   . ILE   A 1 59  ? -26.279 -41.869 -7.497  1.000 61.408  0 59  ILE   A N   1 ? 
ATOM   449  C CA  . ILE   A 1 59  ? -26.810 -43.063 -8.140  1.000 67.689  0 59  ILE   A CA  1 ? 
ATOM   450  C C   . ILE   A 1 59  ? -25.697 -43.799 -8.889  1.000 67.007  0 59  ILE   A C   1 ? 
ATOM   451  O O   . ILE   A 1 59  ? -25.680 -45.028 -8.909  1.000 68.385  0 59  ILE   A O   1 ? 
ATOM   452  C CB  . ILE   A 1 59  ? -27.987 -42.722 -9.078  1.000 75.324  0 59  ILE   A CB  1 ? 
ATOM   453  C CG1 . ILE   A 1 59  ? -29.229 -42.306 -8.280  1.000 81.341  0 59  ILE   A CG1 1 ? 
ATOM   454  C CG2 . ILE   A 1 59  ? -28.275 -43.887 -10.019 1.000 78.012  0 59  ILE   A CG2 1 ? 
ATOM   455  C CD1 . ILE   A 1 59  ? -30.419 -41.872 -9.116  1.000 83.354  0 59  ILE   A CD1 1 ? 
ATOM   456  N N   . ARG   A 1 60  ? -24.774 -43.037 -9.491  1.000 67.149  0 60  ARG   A N   1 ? 
ATOM   457  C CA  . ARG   A 1 60  ? -23.719 -43.579 -10.338 1.000 66.817  0 60  ARG   A CA  1 ? 
ATOM   458  C C   . ARG   A 1 60  ? -22.546 -44.096 -9.506  1.000 57.409  0 60  ARG   A C   1 ? 
ATOM   459  O O   . ARG   A 1 60  ? -21.522 -44.489 -10.058 1.000 50.582  0 60  ARG   A O   1 ? 
ATOM   460  C CB  . ARG   A 1 60  ? -23.276 -42.500 -11.331 1.000 72.540  0 60  ARG   A CB  1 ? 
ATOM   461  C CG  . ARG   A 1 60  ? -24.256 -42.293 -12.478 1.000 80.253  0 60  ARG   A CG  1 ? 
ATOM   462  C CD  . ARG   A 1 60  ? -24.328 -40.847 -12.924 1.000 86.576  0 60  ARG   A CD  1 ? 
ATOM   463  N NE  . ARG   A 1 60  ? -23.009 -40.238 -13.078 1.000 92.372  0 60  ARG   A NE  1 ? 
ATOM   464  C CZ  . ARG   A 1 60  ? -22.683 -39.001 -12.701 1.000 96.385  0 60  ARG   A CZ  1 ? 
ATOM   465  N NH1 . ARG   A 1 60  ? -21.457 -38.550 -12.908 1.000 94.417  0 60  ARG   A NH1 1 ? 
ATOM   466  N NH2 . ARG   A 1 60  ? -23.582 -38.205 -12.140 1.000 98.958  0 60  ARG   A NH2 1 ? 
ATOM   467  N N   . LYS   A 1 61  ? -22.709 -44.097 -8.179  1.000 58.690  0 61  LYS   A N   1 ? 
ATOM   468  C CA  . LYS   A 1 61  ? -21.728 -44.657 -7.268  1.000 60.605  0 61  LYS   A CA  1 ? 
ATOM   469  C C   . LYS   A 1 61  ? -22.277 -45.962 -6.690  1.000 61.966  0 61  LYS   A C   1 ? 
ATOM   470  O O   . LYS   A 1 61  ? -23.491 -46.156 -6.585  1.000 56.733  0 61  LYS   A O   1 ? 
ATOM   471  C CB  . LYS   A 1 61  ? -21.385 -43.650 -6.163  1.000 56.839  0 61  LYS   A CB  1 ? 
ATOM   472  C CG  . LYS   A 1 61  ? -20.848 -42.314 -6.655  1.000 58.959  0 61  LYS   A CG  1 ? 
ATOM   473  C CD  . LYS   A 1 61  ? -19.474 -42.411 -7.282  1.000 60.540  0 61  LYS   A CD  1 ? 
ATOM   474  C CE  . LYS   A 1 61  ? -18.956 -41.082 -7.787  1.000 61.087  0 61  LYS   A CE  1 ? 
ATOM   475  N NZ  . LYS   A 1 61  ? -17.475 -41.041 -7.777  1.000 63.677  0 61  LYS   A NZ  1 ? 
ATOM   476  N N   . SER   A 1 62  ? -21.342 -46.852 -6.341  1.000 60.921  0 62  SER   A N   1 ? 
ATOM   477  C CA  . SER   A 1 62  ? -21.638 -48.115 -5.691  1.000 56.868  0 62  SER   A CA  1 ? 
ATOM   478  C C   . SER   A 1 62  ? -20.564 -48.370 -4.643  1.000 54.567  0 62  SER   A C   1 ? 
ATOM   479  O O   . SER   A 1 62  ? -19.501 -47.745 -4.665  1.000 50.180  0 62  SER   A O   1 ? 
ATOM   480  C CB  . SER   A 1 62  ? -21.709 -49.237 -6.686  1.000 56.599  0 62  SER   A CB  1 ? 
ATOM   481  O OG  . SER   A 1 62  ? -22.579 -48.896 -7.750  1.000 57.962  0 62  SER   A OG  1 ? 
ATOM   482  N N   . ASN   A 1 63  ? -20.847 -49.324 -3.754  1.000 50.501  0 63  ASN   A N   1 ? 
ATOM   483  C CA  . ASN   A 1 63  ? -20.031 -49.535 -2.573  1.000 52.355  0 63  ASN   A CA  1 ? 
ATOM   484  C C   . ASN   A 1 63  ? -18.543 -49.543 -2.929  1.000 52.311  0 63  ASN   A C   1 ? 
ATOM   485  O O   . ASN   A 1 63  ? -17.739 -48.984 -2.191  1.000 53.149  0 63  ASN   A O   1 ? 
ATOM   486  C CB  . ASN   A 1 63  ? -20.452 -50.808 -1.841  1.000 57.921  0 63  ASN   A CB  1 ? 
ATOM   487  C CG  . ASN   A 1 63  ? -21.916 -50.805 -1.452  1.000 64.917  0 63  ASN   A CG  1 ? 
ATOM   488  O OD1 . ASN   A 1 63  ? -22.675 -49.937 -1.878  1.000 69.838  0 63  ASN   A OD1 1 ? 
ATOM   489  N ND2 . ASN   A 1 63  ? -22.327 -51.790 -0.671  1.000 66.415  0 63  ASN   A ND2 1 ? 
ATOM   490  N N   . HIS   A 1 64  ? -18.178 -50.159 -4.060  1.000 51.554  0 64  HIS   A N   1 ? 
ATOM   491  C CA  . HIS   A 1 64  ? -16.782 -50.425 -4.388  1.000 53.675  0 64  HIS   A CA  1 ? 
ATOM   492  C C   . HIS   A 1 64  ? -16.060 -49.164 -4.881  1.000 52.128  0 64  HIS   A C   1 ? 
ATOM   493  O O   . HIS   A 1 64  ? -14.829 -49.148 -4.998  1.000 51.743  0 64  HIS   A O   1 ? 
ATOM   494  C CB  . HIS   A 1 64  ? -16.702 -51.607 -5.369  1.000 57.119  0 64  HIS   A CB  1 ? 
ATOM   495  C CG  . HIS   A 1 64  ? -17.286 -51.340 -6.722  1.000 56.016  0 64  HIS   A CG  1 ? 
ATOM   496  N ND1 . HIS   A 1 64  ? -18.567 -51.715 -7.074  1.000 55.074  0 64  HIS   A ND1 1 ? 
ATOM   497  C CD2 . HIS   A 1 64  ? -16.774 -50.701 -7.789  1.000 52.042  0 64  HIS   A CD2 1 ? 
ATOM   498  C CE1 . HIS   A 1 64  ? -18.806 -51.310 -8.315  1.000 54.476  0 64  HIS   A CE1 1 ? 
ATOM   499  N NE2 . HIS   A 1 64  ? -17.729 -50.698 -8.769  1.000 50.304  0 64  HIS   A NE2 1 ? 
ATOM   500  N N   . ASN   A 1 65  ? -16.828 -48.108 -5.178  1.000 50.727  0 65  ASN   A N   1 ? 
ATOM   501  C CA  . ASN   A 1 65  ? -16.259 -46.836 -5.590  1.000 51.037  0 65  ASN   A CA  1 ? 
ATOM   502  C C   . ASN   A 1 65  ? -15.585 -46.162 -4.406  1.000 54.000  0 65  ASN   A C   1 ? 
ATOM   503  O O   . ASN   A 1 65  ? -14.761 -45.275 -4.605  1.000 61.192  0 65  ASN   A O   1 ? 
ATOM   504  C CB  . ASN   A 1 65  ? -17.314 -45.854 -6.092  1.000 51.531  0 65  ASN   A CB  1 ? 
ATOM   505  C CG  . ASN   A 1 65  ? -18.032 -46.340 -7.327  1.000 54.130  0 65  ASN   A CG  1 ? 
ATOM   506  O OD1 . ASN   A 1 65  ? -19.099 -46.939 -7.230  1.000 53.355  0 65  ASN   A OD1 1 ? 
ATOM   507  N ND2 . ASN   A 1 65  ? -17.437 -46.112 -8.484  1.000 57.780  0 65  ASN   A ND2 1 ? 
ATOM   508  N N   . PHE   A 1 66  ? -15.988 -46.564 -3.192  1.000 53.039  0 66  PHE   A N   1 ? 
ATOM   509  C CA  . PHE   A 1 66  ? -15.624 -45.870 -1.966  1.000 53.669  0 66  PHE   A CA  1 ? 
ATOM   510  C C   . PHE   A 1 66  ? -14.480 -46.595 -1.269  1.000 51.714  0 66  PHE   A C   1 ? 
ATOM   511  O O   . PHE   A 1 66  ? -14.694 -47.613 -0.614  1.000 48.783  0 66  PHE   A O   1 ? 
ATOM   512  C CB  . PHE   A 1 66  ? -16.821 -45.798 -1.013  1.000 52.154  0 66  PHE   A CB  1 ? 
ATOM   513  C CG  . PHE   A 1 66  ? -17.960 -44.934 -1.488  1.000 52.805  0 66  PHE   A CG  1 ? 
ATOM   514  C CD1 . PHE   A 1 66  ? -17.783 -43.571 -1.673  1.000 53.143  0 66  PHE   A CD1 1 ? 
ATOM   515  C CD2 . PHE   A 1 66  ? -19.209 -45.483 -1.746  1.000 55.331  0 66  PHE   A CD2 1 ? 
ATOM   516  C CE1 . PHE   A 1 66  ? -18.832 -42.778 -2.111  1.000 51.990  0 66  PHE   A CE1 1 ? 
ATOM   517  C CE2 . PHE   A 1 66  ? -20.259 -44.687 -2.181  1.000 54.516  0 66  PHE   A CE2 1 ? 
ATOM   518  C CZ  . PHE   A 1 66  ? -20.067 -43.336 -2.363  1.000 53.193  0 66  PHE   A CZ  1 ? 
ATOM   519  N N   . LEU   A 1 67  ? -13.276 -46.035 -1.377  1.000 50.952  0 67  LEU   A N   1 ? 
ATOM   520  C CA  . LEU   A 1 67  ? -12.114 -46.637 -0.749  1.000 55.340  0 67  LEU   A CA  1 ? 
ATOM   521  C C   . LEU   A 1 67  ? -11.889 -46.004 0.620   1.000 51.672  0 67  LEU   A C   1 ? 
ATOM   522  O O   . LEU   A 1 67  ? -11.743 -44.790 0.728   1.000 47.955  0 67  LEU   A O   1 ? 
ATOM   523  C CB  . LEU   A 1 67  ? -10.905 -46.460 -1.667  1.000 65.139  0 67  LEU   A CB  1 ? 
ATOM   524  C CG  . LEU   A 1 67  ? -10.683 -47.588 -2.671  1.000 75.781  0 67  LEU   A CG  1 ? 
ATOM   525  C CD1 . LEU   A 1 67  ? -11.908 -47.833 -3.555  1.000 76.717  0 67  LEU   A CD1 1 ? 
ATOM   526  C CD2 . LEU   A 1 67  ? -9.471  -47.270 -3.524  1.000 84.446  0 67  LEU   A CD2 1 ? 
ATOM   527  N N   . VAL   A 1 68  ? -11.863 -46.861 1.647   1.000 49.835  0 68  VAL   A N   1 ? 
ATOM   528  C CA  . VAL   A 1 68  ? -11.730 -46.444 3.028   1.000 49.746  0 68  VAL   A CA  1 ? 
ATOM   529  C C   . VAL   A 1 68  ? -10.499 -47.108 3.639   1.000 52.050  0 68  VAL   A C   1 ? 
ATOM   530  O O   . VAL   A 1 68  ? -10.450 -48.332 3.789   1.000 50.619  0 68  VAL   A O   1 ? 
ATOM   531  C CB  . VAL   A 1 68  ? -12.992 -46.809 3.824   1.000 50.987  0 68  VAL   A CB  1 ? 
ATOM   532  C CG1 . VAL   A 1 68  ? -12.900 -46.308 5.260   1.000 50.125  0 68  VAL   A CG1 1 ? 
ATOM   533  C CG2 . VAL   A 1 68  ? -14.253 -46.307 3.138   1.000 50.829  0 68  VAL   A CG2 1 ? 
ATOM   534  N N   . GLN   A 1 69  ? -9.530  -46.281 4.039   1.000 52.581  0 69  GLN   A N   1 ? 
ATOM   535  C CA  . GLN   A 1 69  ? -8.252  -46.780 4.511   1.000 54.205  0 69  GLN   A CA  1 ? 
ATOM   536  C C   . GLN   A 1 69  ? -8.066  -46.387 5.969   1.000 53.992  0 69  GLN   A C   1 ? 
ATOM   537  O O   . GLN   A 1 69  ? -8.179  -45.218 6.312   1.000 55.513  0 69  GLN   A O   1 ? 
ATOM   538  C CB  . GLN   A 1 69  ? -7.143  -46.202 3.639   1.000 60.483  0 69  GLN   A CB  1 ? 
ATOM   539  C CG  . GLN   A 1 69  ? -5.792  -46.861 3.841   1.000 64.184  0 69  GLN   A CG  1 ? 
ATOM   540  C CD  . GLN   A 1 69  ? -5.114  -47.077 2.509   1.000 72.455  0 69  GLN   A CD  1 ? 
ATOM   541  O OE1 . GLN   A 1 69  ? -5.043  -46.178 1.672   1.000 69.951  0 69  GLN   A OE1 1 ? 
ATOM   542  N NE2 . GLN   A 1 69  ? -4.641  -48.294 2.286   1.000 78.991  0 69  GLN   A NE2 1 ? 
ATOM   543  N N   . ALA   A 1 70  ? -7.804  -47.383 6.814   1.000 55.842  0 70  ALA   A N   1 ? 
ATOM   544  C CA  . ALA   A 1 70  ? -7.485  -47.161 8.211   1.000 57.667  0 70  ALA   A CA  1 ? 
ATOM   545  C C   . ALA   A 1 70  ? -5.988  -47.390 8.414   1.000 59.944  0 70  ALA   A C   1 ? 
ATOM   546  O O   . ALA   A 1 70  ? -5.558  -48.487 8.749   1.000 63.334  0 70  ALA   A O   1 ? 
ATOM   547  C CB  . ALA   A 1 70  ? -8.322  -48.088 9.053   1.000 57.814  0 70  ALA   A CB  1 ? 
ATOM   548  N N   . GLY   A 1 71  ? -5.185  -46.350 8.188   1.000 59.679  0 71  GLY   A N   1 ? 
ATOM   549  C CA  . GLY   A 1 71  ? -3.752  -46.538 8.085   1.000 61.610  0 71  GLY   A CA  1 ? 
ATOM   550  C C   . GLY   A 1 71  ? -3.419  -47.355 6.841   1.000 65.890  0 71  GLY   A C   1 ? 
ATOM   551  O O   . GLY   A 1 71  ? -3.136  -46.785 5.791   1.000 68.757  0 71  GLY   A O   1 ? 
ATOM   552  N N   . ASN   A 1 72  ? -3.495  -48.687 6.966   1.000 65.420  0 72  ASN   A N   1 ? 
ATOM   553  C CA  . ASN   A 1 72  ? -3.204  -49.602 5.868   1.000 67.337  0 72  ASN   A CA  1 ? 
ATOM   554  C C   . ASN   A 1 72  ? -4.362  -50.574 5.675   1.000 66.043  0 72  ASN   A C   1 ? 
ATOM   555  O O   . ASN   A 1 72  ? -4.662  -50.968 4.553   1.000 72.910  0 72  ASN   A O   1 ? 
ATOM   556  C CB  . ASN   A 1 72  ? -1.936  -50.426 6.105   1.000 70.160  0 72  ASN   A CB  1 ? 
ATOM   557  C CG  . ASN   A 1 72  ? -0.915  -49.698 6.954   1.000 73.622  0 72  ASN   A CG  1 ? 
ATOM   558  O OD1 . ASN   A 1 72  ? -0.362  -48.687 6.531   1.000 76.099  0 72  ASN   A OD1 1 ? 
ATOM   559  N ND2 . ASN   A 1 72  ? -0.675  -50.190 8.160   1.000 73.509  0 72  ASN   A ND2 1 ? 
ATOM   560  N N   . VAL   A 1 73  ? -4.946  -51.007 6.792   1.000 66.332  0 73  VAL   A N   1 ? 
ATOM   561  C CA  . VAL   A 1 73  ? -6.190  -51.762 6.803   1.000 71.600  0 73  VAL   A CA  1 ? 
ATOM   562  C C   . VAL   A 1 73  ? -7.184  -51.105 5.846   1.000 70.702  0 73  VAL   A C   1 ? 
ATOM   563  O O   . VAL   A 1 73  ? -7.567  -49.955 6.036   1.000 69.572  0 73  VAL   A O   1 ? 
ATOM   564  C CB  . VAL   A 1 73  ? -6.811  -51.838 8.215   1.000 78.515  0 73  VAL   A CB  1 ? 
ATOM   565  C CG1 . VAL   A 1 73  ? -7.726  -53.046 8.363   1.000 79.879  0 73  VAL   A CG1 1 ? 
ATOM   566  C CG2 . VAL   A 1 73  ? -5.772  -51.834 9.324   1.000 79.998  0 73  VAL   A CG2 1 ? 
ATOM   567  N N   . GLN   A 1 74  ? -7.619  -51.859 4.834   1.000 72.120  0 74  GLN   A N   1 ? 
ATOM   568  C CA  . GLN   A 1 74  ? -8.678  -51.411 3.949   1.000 72.539  0 74  GLN   A CA  1 ? 
ATOM   569  C C   . GLN   A 1 74  ? -9.989  -52.045 4.396   1.000 63.964  0 74  GLN   A C   1 ? 
ATOM   570  O O   . GLN   A 1 74  ? -10.104 -53.265 4.455   1.000 59.475  0 74  GLN   A O   1 ? 
ATOM   571  C CB  . GLN   A 1 74  ? -8.334  -51.757 2.500   1.000 81.947  0 74  GLN   A CB  1 ? 
ATOM   572  C CG  . GLN   A 1 74  ? -7.498  -50.688 1.799   1.000 89.889  0 74  GLN   A CG  1 ? 
ATOM   573  C CD  . GLN   A 1 74  ? -8.298  -49.535 1.227   1.000 98.011  0 74  GLN   A CD  1 ? 
ATOM   574  O OE1 . GLN   A 1 74  ? -7.900  -48.373 1.318   1.000 103.290 0 74  GLN   A OE1 1 ? 
ATOM   575  N NE2 . GLN   A 1 74  ? -9.416  -49.844 0.585   1.000 97.583  0 74  GLN   A NE2 1 ? 
ATOM   576  N N   . LEU   A 1 75  ? -10.966 -51.196 4.720   1.000 60.372  0 75  LEU   A N   1 ? 
ATOM   577  C CA  . LEU   A 1 75  ? -12.258 -51.675 5.172   1.000 63.591  0 75  LEU   A CA  1 ? 
ATOM   578  C C   . LEU   A 1 75  ? -13.166 -51.849 3.964   1.000 57.769  0 75  LEU   A C   1 ? 
ATOM   579  O O   . LEU   A 1 75  ? -13.160 -51.020 3.058   1.000 56.501  0 75  LEU   A O   1 ? 
ATOM   580  C CB  . LEU   A 1 75  ? -12.886 -50.669 6.140   1.000 71.565  0 75  LEU   A CB  1 ? 
ATOM   581  C CG  . LEU   A 1 75  ? -11.964 -50.080 7.205   1.000 73.667  0 75  LEU   A CG  1 ? 
ATOM   582  C CD1 . LEU   A 1 75  ? -12.775 -49.290 8.223   1.000 73.306  0 75  LEU   A CD1 1 ? 
ATOM   583  C CD2 . LEU   A 1 75  ? -11.149 -51.166 7.891   1.000 76.892  0 75  LEU   A CD2 1 ? 
ATOM   584  N N   . ARG   A 1 76  ? -13.972 -52.907 3.996   1.000 52.366  0 76  ARG   A N   1 ? 
ATOM   585  C CA  . ARG   A 1 76  ? -14.892 -53.188 2.914   1.000 53.459  0 76  ARG   A CA  1 ? 
ATOM   586  C C   . ARG   A 1 76  ? -16.218 -52.505 3.213   1.000 44.520  0 76  ARG   A C   1 ? 
ATOM   587  O O   . ARG   A 1 76  ? -16.774 -52.680 4.284   1.000 42.446  0 76  ARG   A O   1 ? 
ATOM   588  C CB  . ARG   A 1 76  ? -15.079 -54.698 2.756   1.000 59.253  0 76  ARG   A CB  1 ? 
ATOM   589  C CG  . ARG   A 1 76  ? -15.844 -55.099 1.505   1.000 65.083  0 76  ARG   A CG  1 ? 
ATOM   590  C CD  . ARG   A 1 76  ? -16.232 -56.562 1.572   1.000 70.082  0 76  ARG   A CD  1 ? 
ATOM   591  N NE  . ARG   A 1 76  ? -15.090 -57.423 1.843   1.000 76.134  0 76  ARG   A NE  1 ? 
ATOM   592  C CZ  . ARG   A 1 76  ? -14.030 -57.572 1.047   1.000 74.376  0 76  ARG   A CZ  1 ? 
ATOM   593  N NH1 . ARG   A 1 76  ? -13.993 -57.017 -0.153  1.000 71.883  0 76  ARG   A NH1 1 ? 
ATOM   594  N NH2 . ARG   A 1 76  ? -13.003 -58.295 1.456   1.000 76.207  0 76  ARG   A NH2 1 ? 
ATOM   595  N N   . VAL   A 1 77  ? -16.706 -51.741 2.239   1.000 42.268  0 77  VAL   A N   1 ? 
ATOM   596  C CA  . VAL   A 1 77  ? -17.992 -51.075 2.311   1.000 39.975  0 77  VAL   A CA  1 ? 
ATOM   597  C C   . VAL   A 1 77  ? -19.053 -52.061 1.845   1.000 39.520  0 77  VAL   A C   1 ? 
ATOM   598  O O   . VAL   A 1 77  ? -18.971 -52.573 0.739   1.000 39.970  0 77  VAL   A O   1 ? 
ATOM   599  C CB  . VAL   A 1 77  ? -17.965 -49.828 1.412   1.000 39.724  0 77  VAL   A CB  1 ? 
ATOM   600  C CG1 . VAL   A 1 77  ? -19.305 -49.101 1.345   1.000 40.228  0 77  VAL   A CG1 1 ? 
ATOM   601  C CG2 . VAL   A 1 77  ? -16.848 -48.892 1.841   1.000 40.081  0 77  VAL   A CG2 1 ? 
ATOM   602  N N   . ILE   A 1 78  ? -20.057 -52.313 2.676   1.000 39.609  0 78  ILE   A N   1 ? 
ATOM   603  C CA  . ILE   A 1 78  ? -21.066 -53.297 2.332   1.000 41.542  0 78  ILE   A CA  1 ? 
ATOM   604  C C   . ILE   A 1 78  ? -22.431 -52.621 2.264   1.000 44.094  0 78  ILE   A C   1 ? 
ATOM   605  O O   . ILE   A 1 78  ? -23.466 -53.286 2.251   1.000 45.752  0 78  ILE   A O   1 ? 
ATOM   606  C CB  . ILE   A 1 78  ? -21.004 -54.466 3.330   1.000 45.240  0 78  ILE   A CB  1 ? 
ATOM   607  C CG1 . ILE   A 1 78  ? -21.386 -54.048 4.757   1.000 48.054  0 78  ILE   A CG1 1 ? 
ATOM   608  C CG2 . ILE   A 1 78  ? -19.625 -55.105 3.262   1.000 47.245  0 78  ILE   A CG2 1 ? 
ATOM   609  C CD1 . ILE   A 1 78  ? -21.110 -55.082 5.844   1.000 45.927  0 78  ILE   A CD1 1 ? 
ATOM   610  N N   . GLY   A 1 79  ? -22.404 -51.291 2.146   1.000 46.706  0 79  GLY   A N   1 ? 
ATOM   611  C CA  . GLY   A 1 79  ? -23.605 -50.478 2.195   1.000 49.602  0 79  GLY   A CA  1 ? 
ATOM   612  C C   . GLY   A 1 79  ? -23.242 -49.002 2.311   1.000 52.265  0 79  GLY   A C   1 ? 
ATOM   613  O O   . GLY   A 1 79  ? -22.173 -48.672 2.815   1.000 55.919  0 79  GLY   A O   1 ? 
ATOM   614  N N   . HIS   A 1 80  ? -24.124 -48.131 1.816   1.000 52.554  0 80  HIS   A N   1 ? 
ATOM   615  C CA  . HIS   A 1 80  ? -23.880 -46.700 1.832   1.000 55.752  0 80  HIS   A CA  1 ? 
ATOM   616  C C   . HIS   A 1 80  ? -25.209 -45.959 1.782   1.000 57.030  0 80  HIS   A C   1 ? 
ATOM   617  O O   . HIS   A 1 80  ? -26.233 -46.512 1.380   1.000 58.132  0 80  HIS   A O   1 ? 
ATOM   618  C CB  . HIS   A 1 80  ? -22.947 -46.284 0.691   1.000 60.691  0 80  HIS   A CB  1 ? 
ATOM   619  C CG  . HIS   A 1 80  ? -23.498 -46.498 -0.685  1.000 66.192  0 80  HIS   A CG  1 ? 
ATOM   620  N ND1 . HIS   A 1 80  ? -23.911 -47.722 -1.170  1.000 72.041  0 80  HIS   A ND1 1 ? 
ATOM   621  C CD2 . HIS   A 1 80  ? -23.687 -45.625 -1.682  1.000 63.599  0 80  HIS   A CD2 1 ? 
ATOM   622  C CE1 . HIS   A 1 80  ? -24.341 -47.575 -2.416  1.000 71.192  0 80  HIS   A CE1 1 ? 
ATOM   623  N NE2 . HIS   A 1 80  ? -24.207 -46.309 -2.748  1.000 65.614  0 80  HIS   A NE2 1 ? 
ATOM   624  N N   . SER   A 1 81  ? -25.169 -44.690 2.189   1.000 54.228  0 81  SER   A N   1 ? 
ATOM   625  C CA  . SER   A 1 81  ? -26.384 -43.949 2.459   1.000 53.319  0 81  SER   A CA  1 ? 
ATOM   626  C C   . SER   A 1 81  ? -26.041 -42.480 2.676   1.000 55.744  0 81  SER   A C   1 ? 
ATOM   627  O O   . SER   A 1 81  ? -25.022 -42.165 3.291   1.000 60.831  0 81  SER   A O   1 ? 
ATOM   628  C CB  . SER   A 1 81  ? -27.095 -44.528 3.649   1.000 51.066  0 81  SER   A CB  1 ? 
ATOM   629  O OG  . SER   A 1 81  ? -28.445 -44.108 3.666   1.000 52.779  0 81  SER   A OG  1 ? 
ATOM   630  N N   . MET   A 1 82  ? -26.889 -41.591 2.147   1.000 52.770  0 82  MET   A N   1 ? 
ATOM   631  C CA  . MET   A 1 82  ? -26.684 -40.162 2.292   1.000 52.462  0 82  MET   A CA  1 ? 
ATOM   632  C C   . MET   A 1 82  ? -27.631 -39.688 3.380   1.000 50.333  0 82  MET   A C   1 ? 
ATOM   633  O O   . MET   A 1 82  ? -28.822 -39.972 3.301   1.000 50.316  0 82  MET   A O   1 ? 
ATOM   634  C CB  . MET   A 1 82  ? -26.972 -39.404 0.990   1.000 51.878  0 82  MET   A CB  1 ? 
ATOM   635  C CG  . MET   A 1 82  ? -26.793 -37.896 1.106   1.000 56.217  0 82  MET   A CG  1 ? 
ATOM   636  S SD  . MET   A 1 82  ? -26.764 -37.024 -0.500  1.000 63.569  0 82  MET   A SD  1 ? 
ATOM   637  C CE  . MET   A 1 82  ? -28.520 -36.823 -0.804  1.000 63.054  0 82  MET   A CE  1 ? 
ATOM   638  N N   . GLN   A 1 83  ? -27.084 -39.021 4.404   1.000 50.031  0 83  GLN   A N   1 ? 
ATOM   639  C CA  . GLN   A 1 83  ? -27.910 -38.378 5.413   1.000 50.436  0 83  GLN   A CA  1 ? 
ATOM   640  C C   . GLN   A 1 83  ? -27.615 -36.884 5.363   1.000 46.708  0 83  GLN   A C   1 ? 
ATOM   641  O O   . GLN   A 1 83  ? -26.492 -36.465 5.654   1.000 44.024  0 83  GLN   A O   1 ? 
ATOM   642  C CB  . GLN   A 1 83  ? -27.664 -38.958 6.807   1.000 53.155  0 83  GLN   A CB  1 ? 
ATOM   643  C CG  . GLN   A 1 83  ? -28.951 -39.177 7.589   1.000 56.569  0 83  GLN   A CG  1 ? 
ATOM   644  C CD  . GLN   A 1 83  ? -28.740 -39.083 9.078   1.000 60.756  0 83  GLN   A CD  1 ? 
ATOM   645  O OE1 . GLN   A 1 83  ? -27.745 -39.563 9.617   1.000 67.776  0 83  GLN   A OE1 1 ? 
ATOM   646  N NE2 . GLN   A 1 83  ? -29.672 -38.436 9.753   1.000 61.384  0 83  GLN   A NE2 1 ? 
ATOM   647  N N   . ASN   A 1 84  ? -28.626 -36.111 4.946   1.000 42.713  0 84  ASN   A N   1 ? 
ATOM   648  C CA  . ASN   A 1 84  ? -28.469 -34.685 4.733   1.000 45.673  0 84  ASN   A CA  1 ? 
ATOM   649  C C   . ASN   A 1 84  ? -27.205 -34.423 3.903   1.000 45.153  0 84  ASN   A C   1 ? 
ATOM   650  O O   . ASN   A 1 84  ? -27.162 -34.772 2.727   1.000 44.983  0 84  ASN   A O   1 ? 
ATOM   651  C CB  . ASN   A 1 84  ? -28.530 -33.961 6.078   1.000 48.797  0 84  ASN   A CB  1 ? 
ATOM   652  C CG  . ASN   A 1 84  ? -29.846 -34.215 6.775   1.000 49.336  0 84  ASN   A CG  1 ? 
ATOM   653  O OD1 . ASN   A 1 84  ? -30.903 -34.059 6.162   1.000 47.033  0 84  ASN   A OD1 1 ? 
ATOM   654  N ND2 . ASN   A 1 84  ? -29.784 -34.631 8.032   1.000 47.774  0 84  ASN   A ND2 1 ? 
ATOM   655  N N   . CYS   A 1 85  ? -26.170 -33.831 4.516   1.000 43.682  0 85  CYS   A N   1 ? 
ATOM   656  C CA  . CYS   A 1 85  ? -24.948 -33.489 3.809   1.000 42.784  0 85  CYS   A CA  1 ? 
ATOM   657  C C   . CYS   A 1 85  ? -23.793 -34.398 4.206   1.000 43.800  0 85  CYS   A C   1 ? 
ATOM   658  O O   . CYS   A 1 85  ? -22.639 -34.085 3.914   1.000 40.794  0 85  CYS   A O   1 ? 
ATOM   659  C CB  . CYS   A 1 85  ? -24.554 -32.049 4.088   1.000 44.106  0 85  CYS   A CB  1 ? 
ATOM   660  S SG  . CYS   A 1 85  ? -25.782 -30.895 3.445   1.000 46.780  0 85  CYS   A SG  1 ? 
ATOM   661  N N   . VAL   A 1 86  ? -24.096 -35.513 4.881   1.000 47.739  0 86  VAL   A N   1 ? 
ATOM   662  C CA  . VAL   A 1 86  ? -23.064 -36.502 5.147   1.000 47.439  0 86  VAL   A CA  1 ? 
ATOM   663  C C   . VAL   A 1 86  ? -23.411 -37.793 4.431   1.000 44.253  0 86  VAL   A C   1 ? 
ATOM   664  O O   . VAL   A 1 86  ? -24.552 -38.051 4.057   1.000 40.801  0 86  VAL   A O   1 ? 
ATOM   665  C CB  . VAL   A 1 86  ? -22.841 -36.779 6.645   1.000 46.135  0 86  VAL   A CB  1 ? 
ATOM   666  C CG1 . VAL   A 1 86  ? -22.117 -35.632 7.334   1.000 47.812  0 86  VAL   A CG1 1 ? 
ATOM   667  C CG2 . VAL   A 1 86  ? -24.141 -37.121 7.346   1.000 46.292  0 86  VAL   A CG2 1 ? 
ATOM   668  N N   . LEU   A 1 87  ? -22.375 -38.604 4.306   1.000 45.893  0 87  LEU   A N   1 ? 
ATOM   669  C CA  . LEU   A 1 87  ? -22.496 -39.943 3.786   1.000 49.221  0 87  LEU   A CA  1 ? 
ATOM   670  C C   . LEU   A 1 87  ? -22.147 -40.908 4.911   1.000 48.021  0 87  LEU   A C   1 ? 
ATOM   671  O O   . LEU   A 1 87  ? -21.195 -40.680 5.650   1.000 42.436  0 87  LEU   A O   1 ? 
ATOM   672  C CB  . LEU   A 1 87  ? -21.516 -40.025 2.619   1.000 54.769  0 87  LEU   A CB  1 ? 
ATOM   673  C CG  . LEU   A 1 87  ? -21.807 -41.043 1.524   1.000 58.509  0 87  LEU   A CG  1 ? 
ATOM   674  C CD1 . LEU   A 1 87  ? -23.222 -40.894 0.980   1.000 63.686  0 87  LEU   A CD1 1 ? 
ATOM   675  C CD2 . LEU   A 1 87  ? -20.787 -40.871 0.403   1.000 55.621  0 87  LEU   A CD2 1 ? 
ATOM   676  N N   . LYS   A 1 88  ? -22.967 -41.950 5.055   1.000 53.039  0 88  LYS   A N   1 ? 
ATOM   677  C CA  . LYS   A 1 88  ? -22.746 -42.999 6.037   1.000 53.330  0 88  LYS   A CA  1 ? 
ATOM   678  C C   . LYS   A 1 88  ? -22.418 -44.285 5.287   1.000 50.563  0 88  LYS   A C   1 ? 
ATOM   679  O O   . LYS   A 1 88  ? -23.217 -44.729 4.469   1.000 51.895  0 88  LYS   A O   1 ? 
ATOM   680  C CB  . LYS   A 1 88  ? -23.994 -43.208 6.904   1.000 55.688  0 88  LYS   A CB  1 ? 
ATOM   681  C CG  . LYS   A 1 88  ? -24.438 -42.005 7.729   1.000 56.438  0 88  LYS   A CG  1 ? 
ATOM   682  C CD  . LYS   A 1 88  ? -25.554 -42.309 8.722   1.000 55.881  0 88  LYS   A CD  1 ? 
ATOM   683  C CE  . LYS   A 1 88  ? -26.839 -42.741 8.049   1.000 56.534  0 88  LYS   A CE  1 ? 
ATOM   684  N NZ  . LYS   A 1 88  ? -27.954 -42.854 9.013   1.000 59.574  0 88  LYS   A NZ  1 ? 
ATOM   685  N N   . LEU   A 1 89  ? -21.248 -44.868 5.573   1.000 47.860  0 89  LEU   A N   1 ? 
ATOM   686  C CA  . LEU   A 1 89  ? -20.771 -46.036 4.856   1.000 46.526  0 89  LEU   A CA  1 ? 
ATOM   687  C C   . LEU   A 1 89  ? -20.734 -47.234 5.791   1.000 49.996  0 89  LEU   A C   1 ? 
ATOM   688  O O   . LEU   A 1 89  ? -19.791 -47.367 6.562   1.000 55.733  0 89  LEU   A O   1 ? 
ATOM   689  C CB  . LEU   A 1 89  ? -19.364 -45.761 4.325   1.000 46.166  0 89  LEU   A CB  1 ? 
ATOM   690  C CG  . LEU   A 1 89  ? -19.184 -44.443 3.580   1.000 47.816  0 89  LEU   A CG  1 ? 
ATOM   691  C CD1 . LEU   A 1 89  ? -17.823 -44.392 2.907   1.000 46.245  0 89  LEU   A CD1 1 ? 
ATOM   692  C CD2 . LEU   A 1 89  ? -20.285 -44.238 2.559   1.000 50.033  0 89  LEU   A CD2 1 ? 
ATOM   693  N N   . LYS   A 1 90  ? -21.752 -48.098 5.701   1.000 50.217  0 90  LYS   A N   1 ? 
ATOM   694  C CA  . LYS   A 1 90  ? -21.708 -49.423 6.299   1.000 48.060  0 90  LYS   A CA  1 ? 
ATOM   695  C C   . LYS   A 1 90  ? -20.452 -50.155 5.817   1.000 46.238  0 90  LYS   A C   1 ? 
ATOM   696  O O   . LYS   A 1 90  ? -20.183 -50.227 4.616   1.000 43.384  0 90  LYS   A O   1 ? 
ATOM   697  C CB  . LYS   A 1 90  ? -22.993 -50.169 5.929   1.000 50.961  0 90  LYS   A CB  1 ? 
ATOM   698  C CG  . LYS   A 1 90  ? -23.094 -51.605 6.423   1.000 56.051  0 90  LYS   A CG  1 ? 
ATOM   699  C CD  . LYS   A 1 90  ? -23.259 -51.754 7.915   1.000 61.680  0 90  LYS   A CD  1 ? 
ATOM   700  C CE  . LYS   A 1 90  ? -24.601 -51.275 8.425   1.000 68.274  0 90  LYS   A CE  1 ? 
ATOM   701  N NZ  . LYS   A 1 90  ? -24.674 -51.360 9.905   1.000 71.595  0 90  LYS   A NZ  1 ? 
ATOM   702  N N   . VAL   A 1 91  ? -19.664 -50.677 6.766   1.000 46.235  0 91  VAL   A N   1 ? 
ATOM   703  C CA  . VAL   A 1 91  ? -18.470 -51.450 6.453   1.000 46.913  0 91  VAL   A CA  1 ? 
ATOM   704  C C   . VAL   A 1 91  ? -18.505 -52.766 7.224   1.000 48.036  0 91  VAL   A C   1 ? 
ATOM   705  O O   . VAL   A 1 91  ? -19.312 -52.941 8.130   1.000 46.654  0 91  VAL   A O   1 ? 
ATOM   706  C CB  . VAL   A 1 91  ? -17.171 -50.678 6.747   1.000 48.564  0 91  VAL   A CB  1 ? 
ATOM   707  C CG1 . VAL   A 1 91  ? -16.955 -49.544 5.755   1.000 49.965  0 91  VAL   A CG1 1 ? 
ATOM   708  C CG2 . VAL   A 1 91  ? -17.114 -50.169 8.181   1.000 50.354  0 91  VAL   A CG2 1 ? 
ATOM   709  N N   . ASP   A 1 92  ? -17.610 -53.685 6.846   1.000 55.640  0 92  ASP   A N   1 ? 
ATOM   710  C CA  . ASP   A 1 92  ? -17.638 -55.056 7.341   1.000 61.882  0 92  ASP   A CA  1 ? 
ATOM   711  C C   . ASP   A 1 92  ? -17.203 -55.105 8.809   1.000 61.235  0 92  ASP   A C   1 ? 
ATOM   712  O O   . ASP   A 1 92  ? -17.861 -55.763 9.611   1.000 56.492  0 92  ASP   A O   1 ? 
ATOM   713  C CB  . ASP   A 1 92  ? -16.820 -56.000 6.449   1.000 61.046  0 92  ASP   A CB  1 ? 
ATOM   714  C CG  . ASP   A 1 92  ? -15.388 -55.566 6.172   1.000 67.199  0 92  ASP   A CG  1 ? 
ATOM   715  O OD1 . ASP   A 1 92  ? -15.017 -54.420 6.528   1.000 65.905  0 92  ASP   A OD1 1 ? 
ATOM   716  O OD2 . ASP   A 1 92  ? -14.650 -56.382 5.590   1.000 75.723  0 92  ASP   A OD2 1 ? 
ATOM   717  N N   . THR   A 1 93  ? -16.123 -54.383 9.151   1.000 61.812  0 93  THR   A N   1 ? 
ATOM   718  C CA  . THR   A 1 93  ? -15.548 -54.387 10.490  1.000 60.072  0 93  THR   A CA  1 ? 
ATOM   719  C C   . THR   A 1 93  ? -16.119 -53.243 11.334  1.000 60.397  0 93  THR   A C   1 ? 
ATOM   720  O O   . THR   A 1 93  ? -16.329 -52.139 10.831  1.000 65.836  0 93  THR   A O   1 ? 
ATOM   721  C CB  . THR   A 1 93  ? -14.021 -54.275 10.387  1.000 63.739  0 93  THR   A CB  1 ? 
ATOM   722  O OG1 . THR   A 1 93  ? -13.576 -55.291 9.487   1.000 65.959  0 93  THR   A OG1 1 ? 
ATOM   723  C CG2 . THR   A 1 93  ? -13.307 -54.417 11.714  1.000 64.990  0 93  THR   A CG2 1 ? 
ATOM   724  N N   . ALA   A 1 94  ? -16.362 -53.511 12.627  1.000 54.828  0 94  ALA   A N   1 ? 
ATOM   725  C CA  . ALA   A 1 94  ? -16.643 -52.462 13.596  1.000 50.033  0 94  ALA   A CA  1 ? 
ATOM   726  C C   . ALA   A 1 94  ? -15.332 -51.934 14.186  1.000 50.920  0 94  ALA   A C   1 ? 
ATOM   727  O O   . ALA   A 1 94  ? -14.357 -52.669 14.332  1.000 43.161  0 94  ALA   A O   1 ? 
ATOM   728  C CB  . ALA   A 1 94  ? -17.565 -52.977 14.670  1.000 49.630  0 94  ALA   A CB  1 ? 
ATOM   729  N N   . ASN   A 1 95  ? -15.305 -50.642 14.532  1.000 52.340  0 95  ASN   A N   1 ? 
ATOM   730  C CA  . ASN   A 1 95  ? -14.079 -50.031 15.018  1.000 51.296  0 95  ASN   A CA  1 ? 
ATOM   731  C C   . ASN   A 1 95  ? -13.772 -50.555 16.419  1.000 47.256  0 95  ASN   A C   1 ? 
ATOM   732  O O   . ASN   A 1 95  ? -14.541 -50.317 17.347  1.000 43.899  0 95  ASN   A O   1 ? 
ATOM   733  C CB  . ASN   A 1 95  ? -14.151 -48.502 15.002  1.000 48.207  0 95  ASN   A CB  1 ? 
ATOM   734  C CG  . ASN   A 1 95  ? -12.820 -47.834 15.285  1.000 46.411  0 95  ASN   A CG  1 ? 
ATOM   735  O OD1 . ASN   A 1 95  ? -11.783 -48.489 15.419  1.000 41.622  0 95  ASN   A OD1 1 ? 
ATOM   736  N ND2 . ASN   A 1 95  ? -12.844 -46.513 15.375  1.000 47.271  0 95  ASN   A ND2 1 ? 
ATOM   737  N N   . PRO   A 1 96  ? -12.633 -51.260 16.620  1.000 49.371  0 96  PRO   A N   1 ? 
ATOM   738  C CA  . PRO   A 1 96  ? -12.267 -51.762 17.947  1.000 52.669  0 96  PRO   A CA  1 ? 
ATOM   739  C C   . PRO   A 1 96  ? -12.070 -50.656 18.989  1.000 54.484  0 96  PRO   A C   1 ? 
ATOM   740  O O   . PRO   A 1 96  ? -12.250 -50.901 20.184  1.000 51.353  0 96  PRO   A O   1 ? 
ATOM   741  C CB  . PRO   A 1 96  ? -10.963 -52.554 17.707  1.000 51.962  0 96  PRO   A CB  1 ? 
ATOM   742  C CG  . PRO   A 1 96  ? -10.410 -52.016 16.402  1.000 51.798  0 96  PRO   A CG  1 ? 
ATOM   743  C CD  . PRO   A 1 96  ? -11.634 -51.621 15.598  1.000 51.214  0 96  PRO   A CD  1 ? 
ATOM   744  N N   . LYS   A 1 97  ? -11.736 -49.436 18.535  1.000 49.301  0 97  LYS   A N   1 ? 
ATOM   745  C CA  . LYS   A 1 97  ? -11.462 -48.335 19.443  1.000 43.897  0 97  LYS   A CA  1 ? 
ATOM   746  C C   . LYS   A 1 97  ? -12.657 -47.382 19.558  1.000 39.958  0 97  LYS   A C   1 ? 
ATOM   747  O O   . LYS   A 1 97  ? -12.552 -46.351 20.212  1.000 41.018  0 97  LYS   A O   1 ? 
ATOM   748  C CB  . LYS   A 1 97  ? -10.233 -47.570 18.953  1.000 47.192  0 97  LYS   A CB  1 ? 
ATOM   749  C CG  . LYS   A 1 97  ? -9.017  -48.408 18.584  1.000 54.071  0 97  LYS   A CG  1 ? 
ATOM   750  C CD  . LYS   A 1 97  ? -8.418  -47.968 17.249  1.000 62.794  0 97  LYS   A CD  1 ? 
ATOM   751  C CE  . LYS   A 1 97  ? -6.959  -48.325 17.050  1.000 66.735  0 97  LYS   A CE  1 ? 
ATOM   752  N NZ  . LYS   A 1 97  ? -6.054  -47.375 17.741  1.000 68.840  0 97  LYS   A NZ  1 ? 
ATOM   753  N N   . THR   A 1 98  ? -13.800 -47.689 18.935  1.000 38.671  0 98  THR   A N   1 ? 
ATOM   754  C CA  . THR   A 1 98  ? -14.990 -46.866 19.115  1.000 39.208  0 98  THR   A CA  1 ? 
ATOM   755  C C   . THR   A 1 98  ? -15.191 -46.567 20.598  1.000 43.514  0 98  THR   A C   1 ? 
ATOM   756  O O   . THR   A 1 98  ? -15.395 -47.478 21.390  1.000 44.037  0 98  THR   A O   1 ? 
ATOM   757  C CB  . THR   A 1 98  ? -16.257 -47.578 18.628  1.000 39.772  0 98  THR   A CB  1 ? 
ATOM   758  O OG1 . THR   A 1 98  ? -16.035 -48.112 17.323  1.000 40.400  0 98  THR   A OG1 1 ? 
ATOM   759  C CG2 . THR   A 1 98  ? -17.473 -46.678 18.632  1.000 38.692  0 98  THR   A CG2 1 ? 
ATOM   760  N N   . PRO   A 1 99  ? -15.136 -45.301 21.059  1.000 51.793  0 99  PRO   A N   1 ? 
ATOM   761  C CA  . PRO   A 1 99  ? -15.436 -44.996 22.458  1.000 51.015  0 99  PRO   A CA  1 ? 
ATOM   762  C C   . PRO   A 1 99  ? -16.937 -44.898 22.670  1.000 48.946  0 99  PRO   A C   1 ? 
ATOM   763  O O   . PRO   A 1 99  ? -17.703 -45.096 21.734  1.000 49.382  0 99  PRO   A O   1 ? 
ATOM   764  C CB  . PRO   A 1 99  ? -14.779 -43.630 22.661  1.000 55.404  0 99  PRO   A CB  1 ? 
ATOM   765  C CG  . PRO   A 1 99  ? -14.904 -42.978 21.300  1.000 57.030  0 99  PRO   A CG  1 ? 
ATOM   766  C CD  . PRO   A 1 99  ? -14.770 -44.105 20.291  1.000 55.831  0 99  PRO   A CD  1 ? 
ATOM   767  N N   . LYS   A 1 100 ? -17.345 -44.607 23.906  1.000 50.025  0 100 LYS   A N   1 ? 
ATOM   768  C CA  . LYS   A 1 100 ? -18.684 -44.096 24.128  1.000 48.336  0 100 LYS   A CA  1 ? 
ATOM   769  C C   . LYS   A 1 100 ? -18.737 -42.754 23.421  1.000 46.133  0 100 LYS   A C   1 ? 
ATOM   770  O O   . LYS   A 1 100 ? -17.730 -42.038 23.386  1.000 41.570  0 100 LYS   A O   1 ? 
ATOM   771  C CB  . LYS   A 1 100 ? -19.025 -43.908 25.608  1.000 51.621  0 100 LYS   A CB  1 ? 
ATOM   772  C CG  . LYS   A 1 100 ? -19.095 -45.175 26.449  1.000 57.087  0 100 LYS   A CG  1 ? 
ATOM   773  C CD  . LYS   A 1 100 ? -19.579 -44.894 27.854  1.000 64.686  0 100 LYS   A CD  1 ? 
ATOM   774  C CE  . LYS   A 1 100 ? -19.221 -45.983 28.845  1.000 73.395  0 100 LYS   A CE  1 ? 
ATOM   775  N NZ  . LYS   A 1 100 ? -19.711 -45.667 30.211  1.000 77.253  0 100 LYS   A NZ  1 ? 
ATOM   776  N N   . TYR   A 1 101 ? -19.902 -42.451 22.842  1.000 43.720  0 101 TYR   A N   1 ? 
ATOM   777  C CA  . TYR   A 1 101 ? -20.027 -41.277 22.006  1.000 45.253  0 101 TYR   A CA  1 ? 
ATOM   778  C C   . TYR   A 1 101 ? -21.491 -40.941 21.757  1.000 44.867  0 101 TYR   A C   1 ? 
ATOM   779  O O   . TYR   A 1 101 ? -22.352 -41.811 21.844  1.000 42.141  0 101 TYR   A O   1 ? 
ATOM   780  C CB  . TYR   A 1 101 ? -19.296 -41.583 20.697  1.000 49.535  0 101 TYR   A CB  1 ? 
ATOM   781  C CG  . TYR   A 1 101 ? -20.012 -42.563 19.775  1.000 47.083  0 101 TYR   A CG  1 ? 
ATOM   782  C CD1 . TYR   A 1 101 ? -20.981 -42.125 18.881  1.000 46.525  0 101 TYR   A CD1 1 ? 
ATOM   783  C CD2 . TYR   A 1 101 ? -19.716 -43.918 19.796  1.000 46.886  0 101 TYR   A CD2 1 ? 
ATOM   784  C CE1 . TYR   A 1 101 ? -21.622 -43.002 18.022  1.000 46.438  0 101 TYR   A CE1 1 ? 
ATOM   785  C CE2 . TYR   A 1 101 ? -20.353 -44.806 18.948  1.000 47.765  0 101 TYR   A CE2 1 ? 
ATOM   786  C CZ  . TYR   A 1 101 ? -21.309 -44.345 18.063  1.000 46.983  0 101 TYR   A CZ  1 ? 
ATOM   787  O OH  . TYR   A 1 101 ? -21.968 -45.205 17.248  1.000 52.311  0 101 TYR   A OH  1 ? 
ATOM   788  N N   . LYS   A 1 102 ? -21.737 -39.671 21.410  1.000 45.581  0 102 LYS   A N   1 ? 
ATOM   789  C CA  . LYS   A 1 102 ? -23.052 -39.209 21.003  1.000 47.602  0 102 LYS   A CA  1 ? 
ATOM   790  C C   . LYS   A 1 102 ? -22.915 -38.118 19.941  1.000 44.033  0 102 LYS   A C   1 ? 
ATOM   791  O O   . LYS   A 1 102 ? -21.889 -37.449 19.828  1.000 40.449  0 102 LYS   A O   1 ? 
ATOM   792  C CB  . LYS   A 1 102 ? -23.847 -38.648 22.186  1.000 52.995  0 102 LYS   A CB  1 ? 
ATOM   793  C CG  . LYS   A 1 102 ? -23.862 -39.508 23.443  1.000 59.609  0 102 LYS   A CG  1 ? 
ATOM   794  C CD  . LYS   A 1 102 ? -24.959 -39.158 24.443  1.000 65.592  0 102 LYS   A CD  1 ? 
ATOM   795  C CE  . LYS   A 1 102 ? -25.143 -37.671 24.672  1.000 71.805  0 102 LYS   A CE  1 ? 
ATOM   796  N NZ  . LYS   A 1 102 ? -23.878 -36.976 25.020  1.000 71.980  0 102 LYS   A NZ  1 ? 
ATOM   797  N N   . PHE   A 1 103 ? -23.987 -37.953 19.169  1.000 43.257  0 103 PHE   A N   1 ? 
ATOM   798  C CA  . PHE   A 1 103 ? -24.099 -36.865 18.222  1.000 50.182  0 103 PHE   A CA  1 ? 
ATOM   799  C C   . PHE   A 1 103 ? -24.884 -35.750 18.894  1.000 50.546  0 103 PHE   A C   1 ? 
ATOM   800  O O   . PHE   A 1 103 ? -26.023 -35.950 19.302  1.000 48.687  0 103 PHE   A O   1 ? 
ATOM   801  C CB  . PHE   A 1 103 ? -24.775 -37.333 16.928  1.000 54.647  0 103 PHE   A CB  1 ? 
ATOM   802  C CG  . PHE   A 1 103 ? -24.023 -38.378 16.137  1.000 55.535  0 103 PHE   A CG  1 ? 
ATOM   803  C CD1 . PHE   A 1 103 ? -22.671 -38.621 16.356  1.000 57.590  0 103 PHE   A CD1 1 ? 
ATOM   804  C CD2 . PHE   A 1 103 ? -24.680 -39.141 15.181  1.000 57.156  0 103 PHE   A CD2 1 ? 
ATOM   805  C CE1 . PHE   A 1 103 ? -21.993 -39.586 15.623  1.000 58.176  0 103 PHE   A CE1 1 ? 
ATOM   806  C CE2 . PHE   A 1 103 ? -24.001 -40.107 14.452  1.000 57.011  0 103 PHE   A CE2 1 ? 
ATOM   807  C CZ  . PHE   A 1 103 ? -22.659 -40.328 14.675  1.000 56.238  0 103 PHE   A CZ  1 ? 
ATOM   808  N N   . VAL   A 1 104 ? -24.248 -34.587 19.012  1.000 51.452  0 104 VAL   A N   1 ? 
ATOM   809  C CA  . VAL   A 1 104 ? -24.888 -33.426 19.594  1.000 52.722  0 104 VAL   A CA  1 ? 
ATOM   810  C C   . VAL   A 1 104 ? -24.929 -32.340 18.531  1.000 51.163  0 104 VAL   A C   1 ? 
ATOM   811  O O   . VAL   A 1 104 ? -24.115 -32.336 17.610  1.000 51.766  0 104 VAL   A O   1 ? 
ATOM   812  C CB  . VAL   A 1 104 ? -24.146 -32.958 20.859  1.000 56.459  0 104 VAL   A CB  1 ? 
ATOM   813  C CG1 . VAL   A 1 104 ? -24.089 -34.056 21.908  1.000 55.442  0 104 VAL   A CG1 1 ? 
ATOM   814  C CG2 . VAL   A 1 104 ? -22.744 -32.464 20.543  1.000 60.773  0 104 VAL   A CG2 1 ? 
ATOM   815  N N   . ARG   A 1 105 ? -25.922 -31.462 18.657  1.000 48.839  0 105 ARG   A N   1 ? 
ATOM   816  C CA  . ARG   A 1 105 ? -25.943 -30.219 17.914  1.000 50.242  0 105 ARG   A CA  1 ? 
ATOM   817  C C   . ARG   A 1 105 ? -25.836 -29.081 18.933  1.000 50.815  0 105 ARG   A C   1 ? 
ATOM   818  O O   . ARG   A 1 105 ? -26.784 -28.802 19.659  1.000 47.832  0 105 ARG   A O   1 ? 
ATOM   819  C CB  . ARG   A 1 105 ? -27.199 -30.138 17.036  1.000 48.270  0 105 ARG   A CB  1 ? 
ATOM   820  C CG  . ARG   A 1 105 ? -27.125 -29.066 15.956  1.000 47.352  0 105 ARG   A CG  1 ? 
ATOM   821  C CD  . ARG   A 1 105 ? -28.453 -28.796 15.272  1.000 48.970  0 105 ARG   A CD  1 ? 
ATOM   822  N NE  . ARG   A 1 105 ? -28.338 -27.769 14.242  1.000 51.085  0 105 ARG   A NE  1 ? 
ATOM   823  C CZ  . ARG   A 1 105 ? -27.706 -27.914 13.077  1.000 56.145  0 105 ARG   A CZ  1 ? 
ATOM   824  N NH1 . ARG   A 1 105 ? -27.254 -29.096 12.695  1.000 58.500  0 105 ARG   A NH1 1 ? 
ATOM   825  N NH2 . ARG   A 1 105 ? -27.550 -26.874 12.277  1.000 55.137  0 105 ARG   A NH2 1 ? 
ATOM   826  N N   . ILE   A 1 106 ? -24.658 -28.449 18.989  1.000 47.796  0 106 ILE   A N   1 ? 
ATOM   827  C CA  . ILE   A 1 106 ? -24.376 -27.394 19.942  1.000 43.773  0 106 ILE   A CA  1 ? 
ATOM   828  C C   . ILE   A 1 106 ? -25.146 -26.133 19.571  1.000 46.167  0 106 ILE   A C   1 ? 
ATOM   829  O O   . ILE   A 1 106 ? -25.512 -25.927 18.416  1.000 43.778  0 106 ILE   A O   1 ? 
ATOM   830  C CB  . ILE   A 1 106 ? -22.867 -27.108 20.014  1.000 43.748  0 106 ILE   A CB  1 ? 
ATOM   831  C CG1 . ILE   A 1 106 ? -22.320 -26.636 18.665  1.000 46.924  0 106 ILE   A CG1 1 ? 
ATOM   832  C CG2 . ILE   A 1 106 ? -22.118 -28.314 20.552  1.000 41.280  0 106 ILE   A CG2 1 ? 
ATOM   833  C CD1 . ILE   A 1 106 ? -20.810 -26.511 18.615  1.000 50.671  0 106 ILE   A CD1 1 ? 
ATOM   834  N N   . GLN   A 1 107 ? -25.365 -25.302 20.593  1.000 51.429  0 107 GLN   A N   1 ? 
ATOM   835  C CA  . GLN   A 1 107 ? -25.939 -23.977 20.447  1.000 53.388  0 107 GLN   A CA  1 ? 
ATOM   836  C C   . GLN   A 1 107 ? -24.830 -23.010 20.055  1.000 50.291  0 107 GLN   A C   1 ? 
ATOM   837  O O   . GLN   A 1 107 ? -23.666 -23.245 20.371  1.000 47.893  0 107 GLN   A O   1 ? 
ATOM   838  C CB  . GLN   A 1 107 ? -26.548 -23.517 21.775  1.000 58.655  0 107 GLN   A CB  1 ? 
ATOM   839  C CG  . GLN   A 1 107 ? -27.687 -24.389 22.278  1.000 63.816  0 107 GLN   A CG  1 ? 
ATOM   840  C CD  . GLN   A 1 107 ? -28.898 -24.262 21.387  1.000 71.331  0 107 GLN   A CD  1 ? 
ATOM   841  O OE1 . GLN   A 1 107 ? -29.495 -23.191 21.270  1.000 71.328  0 107 GLN   A OE1 1 ? 
ATOM   842  N NE2 . GLN   A 1 107 ? -29.256 -25.354 20.729  1.000 72.195  0 107 GLN   A NE2 1 ? 
ATOM   843  N N   . PRO   A 1 108 ? -25.159 -21.869 19.410  1.000 52.267  0 108 PRO   A N   1 ? 
ATOM   844  C CA  . PRO   A 1 108 ? -24.155 -20.861 19.081  1.000 53.512  0 108 PRO   A CA  1 ? 
ATOM   845  C C   . PRO   A 1 108 ? -23.608 -20.295 20.384  1.000 52.983  0 108 PRO   A C   1 ? 
ATOM   846  O O   . PRO   A 1 108 ? -24.370 -20.030 21.308  1.000 52.198  0 108 PRO   A O   1 ? 
ATOM   847  C CB  . PRO   A 1 108 ? -24.910 -19.810 18.253  1.000 53.383  0 108 PRO   A CB  1 ? 
ATOM   848  C CG  . PRO   A 1 108 ? -26.358 -19.991 18.657  1.000 54.121  0 108 PRO   A CG  1 ? 
ATOM   849  C CD  . PRO   A 1 108 ? -26.512 -21.456 19.015  1.000 54.266  0 108 PRO   A CD  1 ? 
ATOM   850  N N   . GLY   A 1 109 ? -22.282 -20.173 20.462  1.000 51.538  0 109 GLY   A N   1 ? 
ATOM   851  C CA  . GLY   A 1 109 ? -21.623 -19.769 21.690  1.000 48.767  0 109 GLY   A CA  1 ? 
ATOM   852  C C   . GLY   A 1 109 ? -20.924 -20.941 22.368  1.000 49.777  0 109 GLY   A C   1 ? 
ATOM   853  O O   . GLY   A 1 109 ? -19.958 -20.734 23.102  1.000 48.291  0 109 GLY   A O   1 ? 
ATOM   854  N N   . GLN   A 1 110 ? -21.417 -22.165 22.117  1.000 50.751  0 110 GLN   A N   1 ? 
ATOM   855  C CA  . GLN   A 1 110 ? -20.824 -23.362 22.691  1.000 50.451  0 110 GLN   A CA  1 ? 
ATOM   856  C C   . GLN   A 1 110 ? -19.485 -23.653 22.028  1.000 46.276  0 110 GLN   A C   1 ? 
ATOM   857  O O   . GLN   A 1 110 ? -19.324 -23.398 20.841  1.000 43.965  0 110 GLN   A O   1 ? 
ATOM   858  C CB  . GLN   A 1 110 ? -21.734 -24.569 22.511  1.000 54.928  0 110 GLN   A CB  1 ? 
ATOM   859  C CG  . GLN   A 1 110 ? -22.961 -24.524 23.406  1.000 59.413  0 110 GLN   A CG  1 ? 
ATOM   860  C CD  . GLN   A 1 110 ? -23.412 -25.913 23.770  1.000 60.305  0 110 GLN   A CD  1 ? 
ATOM   861  O OE1 . GLN   A 1 110 ? -24.536 -26.320 23.480  1.000 62.883  0 110 GLN   A OE1 1 ? 
ATOM   862  N NE2 . GLN   A 1 110 ? -22.511 -26.658 24.391  1.000 59.099  0 110 GLN   A NE2 1 ? 
ATOM   863  N N   . THR   A 1 111 ? -18.541 -24.183 22.815  1.000 44.771  0 111 THR   A N   1 ? 
ATOM   864  C CA  . THR   A 1 111 ? -17.190 -24.434 22.335  1.000 47.145  0 111 THR   A CA  1 ? 
ATOM   865  C C   . THR   A 1 111 ? -16.985 -25.928 22.127  1.000 44.520  0 111 THR   A C   1 ? 
ATOM   866  O O   . THR   A 1 111 ? -17.757 -26.731 22.634  1.000 48.271  0 111 THR   A O   1 ? 
ATOM   867  C CB  . THR   A 1 111 ? -16.117 -23.920 23.303  1.000 46.216  0 111 THR   A CB  1 ? 
ATOM   868  O OG1 . THR   A 1 111 ? -16.191 -24.692 24.501  1.000 45.307  0 111 THR   A OG1 1 ? 
ATOM   869  C CG2 . THR   A 1 111 ? -16.265 -22.449 23.611  1.000 48.363  0 111 THR   A CG2 1 ? 
ATOM   870  N N   . PHE   A 1 112 ? -15.928 -26.282 21.394  1.000 39.418  0 112 PHE   A N   1 ? 
ATOM   871  C CA  . PHE   A 1 112 ? -15.576 -27.678 21.206  1.000 39.887  0 112 PHE   A CA  1 ? 
ATOM   872  C C   . PHE   A 1 112 ? -14.153 -27.758 20.681  1.000 35.942  0 112 PHE   A C   1 ? 
ATOM   873  O O   . PHE   A 1 112 ? -13.670 -26.801 20.086  1.000 37.193  0 112 PHE   A O   1 ? 
ATOM   874  C CB  . PHE   A 1 112 ? -16.532 -28.365 20.230  1.000 41.779  0 112 PHE   A CB  1 ? 
ATOM   875  C CG  . PHE   A 1 112 ? -16.646 -27.675 18.891  1.000 47.957  0 112 PHE   A CG  1 ? 
ATOM   876  C CD1 . PHE   A 1 112 ? -17.486 -26.581 18.725  1.000 50.023  0 112 PHE   A CD1 1 ? 
ATOM   877  C CD2 . PHE   A 1 112 ? -15.874 -28.083 17.811  1.000 45.952  0 112 PHE   A CD2 1 ? 
ATOM   878  C CE1 . PHE   A 1 112 ? -17.574 -25.940 17.501  1.000 48.719  0 112 PHE   A CE1 1 ? 
ATOM   879  C CE2 . PHE   A 1 112 ? -15.958 -27.434 16.591  1.000 43.985  0 112 PHE   A CE2 1 ? 
ATOM   880  C CZ  . PHE   A 1 112 ? -16.805 -26.365 16.439  1.000 47.179  0 112 PHE   A CZ  1 ? 
ATOM   881  N N   . SER   A 1 113 ? -13.515 -28.906 20.920  1.000 35.842  0 113 SER   A N   1 ? 
ATOM   882  C CA  . SER   A 1 113 ? -12.188 -29.192 20.401  1.000 37.879  0 113 SER   A CA  1 ? 
ATOM   883  C C   . SER   A 1 113 ? -12.306 -29.792 19.005  1.000 39.515  0 113 SER   A C   1 ? 
ATOM   884  O O   . SER   A 1 113 ? -13.197 -30.601 18.723  1.000 36.122  0 113 SER   A O   1 ? 
ATOM   885  C CB  . SER   A 1 113 ? -11.407 -30.118 21.296  1.000 36.044  0 113 SER   A CB  1 ? 
ATOM   886  O OG  . SER   A 1 113 ? -11.138 -29.514 22.542  1.000 36.046  0 113 SER   A OG  1 ? 
ATOM   887  N N   . VAL   A 1 114 ? -11.352 -29.400 18.162  1.000 41.962  0 114 VAL   A N   1 ? 
ATOM   888  C CA  . VAL   A 1 114 ? -11.294 -29.848 16.786  1.000 38.675  0 114 VAL   A CA  1 ? 
ATOM   889  C C   . VAL   A 1 114 ? -9.941  -30.508 16.562  1.000 36.685  0 114 VAL   A C   1 ? 
ATOM   890  O O   . VAL   A 1 114 ? -8.903  -29.932 16.901  1.000 32.752  0 114 VAL   A O   1 ? 
ATOM   891  C CB  . VAL   A 1 114 ? -11.530 -28.668 15.832  1.000 42.558  0 114 VAL   A CB  1 ? 
ATOM   892  C CG1 . VAL   A 1 114 ? -10.867 -28.880 14.481  1.000 44.886  0 114 VAL   A CG1 1 ? 
ATOM   893  C CG2 . VAL   A 1 114 ? -13.018 -28.393 15.687  1.000 42.690  0 114 VAL   A CG2 1 ? 
ATOM   894  N N   . LEU   A 1 115 ? -10.002 -31.734 16.023  1.000 34.094  0 115 LEU   A N   1 ? 
ATOM   895  C CA  . LEU   A 1 115 ? -8.824  -32.468 15.630  1.000 32.807  0 115 LEU   A CA  1 ? 
ATOM   896  C C   . LEU   A 1 115 ? -8.767  -32.441 14.116  1.000 34.757  0 115 LEU   A C   1 ? 
ATOM   897  O O   . LEU   A 1 115 ? -9.552  -33.134 13.458  1.000 37.425  0 115 LEU   A O   1 ? 
ATOM   898  C CB  . LEU   A 1 115 ? -8.911  -33.906 16.140  1.000 36.304  0 115 LEU   A CB  1 ? 
ATOM   899  C CG  . LEU   A 1 115 ? -7.754  -34.811 15.708  1.000 37.989  0 115 LEU   A CG  1 ? 
ATOM   900  C CD1 . LEU   A 1 115 ? -6.454  -34.436 16.414  1.000 39.040  0 115 LEU   A CD1 1 ? 
ATOM   901  C CD2 . LEU   A 1 115 ? -8.078  -36.273 15.949  1.000 39.736  0 115 LEU   A CD2 1 ? 
ATOM   902  N N   . ALA   A 1 116 ? -7.813  -31.646 13.614  1.000 35.102  0 116 ALA   A N   1 ? 
ATOM   903  C CA  . ALA   A 1 116 ? -7.630  -31.417 12.193  1.000 34.903  0 116 ALA   A CA  1 ? 
ATOM   904  C C   . ALA   A 1 116 ? -6.838  -32.571 11.605  1.000 35.780  0 116 ALA   A C   1 ? 
ATOM   905  O O   . ALA   A 1 116 ? -5.749  -32.886 12.080  1.000 34.258  0 116 ALA   A O   1 ? 
ATOM   906  C CB  . ALA   A 1 116 ? -6.919  -30.112 11.945  1.000 33.704  0 116 ALA   A CB  1 ? 
ATOM   907  N N   . CYS   A 1 117 ? -7.407  -33.155 10.550  1.000 37.553  0 117 CYS   A N   1 ? 
ATOM   908  C CA  . CYS   A 1 117 ? -6.851  -34.324 9.909   1.000 39.603  0 117 CYS   A CA  1 ? 
ATOM   909  C C   . CYS   A 1 117 ? -6.560  -34.031 8.443   1.000 40.473  0 117 CYS   A C   1 ? 
ATOM   910  O O   . CYS   A 1 117 ? -7.257  -33.237 7.814   1.000 39.375  0 117 CYS   A O   1 ? 
ATOM   911  C CB  . CYS   A 1 117 ? -7.820  -35.487 10.034  1.000 42.190  0 117 CYS   A CB  1 ? 
ATOM   912  S SG  . CYS   A 1 117 ? -8.036  -36.010 11.751  1.000 43.279  0 117 CYS   A SG  1 ? 
ATOM   913  N N   . TYR   A 1 118 ? -5.489  -34.666 7.948   1.000 44.363  0 118 TYR   A N   1 ? 
ATOM   914  C CA  . TYR   A 1 118 ? -5.192  -34.756 6.529   1.000 48.499  0 118 TYR   A CA  1 ? 
ATOM   915  C C   . TYR   A 1 118 ? -4.904  -36.223 6.208   1.000 52.792  0 118 TYR   A C   1 ? 
ATOM   916  O O   . TYR   A 1 118 ? -3.976  -36.813 6.768   1.000 58.784  0 118 TYR   A O   1 ? 
ATOM   917  C CB  . TYR   A 1 118 ? -4.068  -33.772 6.180   1.000 48.437  0 118 TYR   A CB  1 ? 
ATOM   918  C CG  . TYR   A 1 118 ? -4.442  -32.329 6.496   1.000 49.220  0 118 TYR   A CG  1 ? 
ATOM   919  C CD1 . TYR   A 1 118 ? -4.178  -31.786 7.747   1.000 50.006  0 118 TYR   A CD1 1 ? 
ATOM   920  C CD2 . TYR   A 1 118 ? -5.150  -31.547 5.587   1.000 46.895  0 118 TYR   A CD2 1 ? 
ATOM   921  C CE1 . TYR   A 1 118 ? -4.550  -30.490 8.064   1.000 49.376  0 118 TYR   A CE1 1 ? 
ATOM   922  C CE2 . TYR   A 1 118 ? -5.536  -30.252 5.898   1.000 47.355  0 118 TYR   A CE2 1 ? 
ATOM   923  C CZ  . TYR   A 1 118 ? -5.233  -29.719 7.141   1.000 45.948  0 118 TYR   A CZ  1 ? 
ATOM   924  O OH  . TYR   A 1 118 ? -5.595  -28.447 7.496   1.000 41.399  0 118 TYR   A OH  1 ? 
ATOM   925  N N   . ASN   A 1 119 ? -5.757  -36.803 5.347   1.000 51.289  0 119 ASN   A N   1 ? 
ATOM   926  C CA  . ASN   A 1 119 ? -5.611  -38.162 4.847   1.000 51.448  0 119 ASN   A CA  1 ? 
ATOM   927  C C   . ASN   A 1 119 ? -5.762  -39.162 5.989   1.000 51.193  0 119 ASN   A C   1 ? 
ATOM   928  O O   . ASN   A 1 119 ? -4.915  -40.043 6.161   1.000 48.191  0 119 ASN   A O   1 ? 
ATOM   929  C CB  . ASN   A 1 119 ? -4.271  -38.379 4.136   1.000 52.461  0 119 ASN   A CB  1 ? 
ATOM   930  C CG  . ASN   A 1 119 ? -4.063  -37.467 2.950   1.000 51.453  0 119 ASN   A CG  1 ? 
ATOM   931  O OD1 . ASN   A 1 119 ? -3.089  -36.722 2.909   1.000 54.387  0 119 ASN   A OD1 1 ? 
ATOM   932  N ND2 . ASN   A 1 119 ? -4.961  -37.520 1.981   1.000 52.938  0 119 ASN   A ND2 1 ? 
ATOM   933  N N   . GLY   A 1 120 ? -6.834  -39.001 6.776   1.000 51.845  0 120 GLY   A N   1 ? 
ATOM   934  C CA  . GLY   A 1 120 ? -7.119  -39.887 7.894   1.000 49.346  0 120 GLY   A CA  1 ? 
ATOM   935  C C   . GLY   A 1 120 ? -6.151  -39.696 9.064   1.000 52.316  0 120 GLY   A C   1 ? 
ATOM   936  O O   . GLY   A 1 120 ? -6.381  -40.234 10.149  1.000 54.555  0 120 GLY   A O   1 ? 
ATOM   937  N N   . SER   A 1 121 ? -5.078  -38.924 8.846   1.000 50.496  0 121 SER   A N   1 ? 
ATOM   938  C CA  . SER   A 1 121 ? -4.037  -38.767 9.843   1.000 52.901  0 121 SER   A CA  1 ? 
ATOM   939  C C   . SER   A 1 121 ? -4.186  -37.413 10.527  1.000 58.569  0 121 SER   A C   1 ? 
ATOM   940  O O   . SER   A 1 121 ? -4.234  -36.392 9.841   1.000 58.391  0 121 SER   A O   1 ? 
ATOM   941  C CB  . SER   A 1 121 ? -2.685  -38.933 9.232   1.000 54.031  0 121 SER   A CB  1 ? 
ATOM   942  O OG  . SER   A 1 121 ? -2.526  -40.260 8.762   1.000 61.462  0 121 SER   A OG  1 ? 
ATOM   943  N N   . PRO   A 1 122 ? -4.231  -37.362 11.884  1.000 61.871  0 122 PRO   A N   1 ? 
ATOM   944  C CA  . PRO   A 1 122 ? -4.473  -36.127 12.625  1.000 57.382  0 122 PRO   A CA  1 ? 
ATOM   945  C C   . PRO   A 1 122 ? -3.202  -35.298 12.766  1.000 55.010  0 122 PRO   A C   1 ? 
ATOM   946  O O   . PRO   A 1 122 ? -2.187  -35.797 13.252  1.000 54.891  0 122 PRO   A O   1 ? 
ATOM   947  C CB  . PRO   A 1 122 ? -4.947  -36.598 14.010  1.000 61.145  0 122 PRO   A CB  1 ? 
ATOM   948  C CG  . PRO   A 1 122 ? -4.936  -38.117 13.965  1.000 62.272  0 122 PRO   A CG  1 ? 
ATOM   949  C CD  . PRO   A 1 122 ? -4.027  -38.485 12.811  1.000 64.289  0 122 PRO   A CD  1 ? 
ATOM   950  N N   . SER   A 1 123 ? -3.302  -34.033 12.346  1.000 50.856  0 123 SER   A N   1 ? 
ATOM   951  C CA  . SER   A 1 123 ? -2.182  -33.116 12.273  1.000 50.418  0 123 SER   A CA  1 ? 
ATOM   952  C C   . SER   A 1 123 ? -2.064  -32.300 13.555  1.000 51.653  0 123 SER   A C   1 ? 
ATOM   953  O O   . SER   A 1 123 ? -0.975  -31.862 13.925  1.000 53.843  0 123 SER   A O   1 ? 
ATOM   954  C CB  . SER   A 1 123 ? -2.355  -32.220 11.091  1.000 55.315  0 123 SER   A CB  1 ? 
ATOM   955  O OG  . SER   A 1 123 ? -3.699  -31.783 10.992  1.000 63.172  0 123 SER   A OG  1 ? 
ATOM   956  N N   . GLY   A 1 124 ? -3.192  -32.061 14.224  1.000 47.120  0 124 GLY   A N   1 ? 
ATOM   957  C CA  . GLY   A 1 124 ? -3.152  -31.243 15.421  1.000 43.440  0 124 GLY   A CA  1 ? 
ATOM   958  C C   . GLY   A 1 124 ? -4.539  -31.011 15.997  1.000 41.635  0 124 GLY   A C   1 ? 
ATOM   959  O O   . GLY   A 1 124 ? -5.528  -31.537 15.490  1.000 43.082  0 124 GLY   A O   1 ? 
ATOM   960  N N   . VAL   A 1 125 ? -4.586  -30.212 17.060  1.000 37.332  0 125 VAL   A N   1 ? 
ATOM   961  C CA  . VAL   A 1 125 ? -5.808  -30.060 17.815  1.000 36.166  0 125 VAL   A CA  1 ? 
ATOM   962  C C   . VAL   A 1 125 ? -5.870  -28.646 18.390  1.000 36.865  0 125 VAL   A C   1 ? 
ATOM   963  O O   . VAL   A 1 125 ? -4.852  -28.101 18.837  1.000 30.892  0 125 VAL   A O   1 ? 
ATOM   964  C CB  . VAL   A 1 125 ? -5.891  -31.150 18.900  1.000 35.898  0 125 VAL   A CB  1 ? 
ATOM   965  C CG1 . VAL   A 1 125 ? -4.679  -31.141 19.814  1.000 35.662  0 125 VAL   A CG1 1 ? 
ATOM   966  C CG2 . VAL   A 1 125 ? -7.169  -31.059 19.715  1.000 36.567  0 125 VAL   A CG2 1 ? 
ATOM   967  N N   . TYR   A 1 126 ? -7.091  -28.084 18.360  1.000 36.235  0 126 TYR   A N   1 ? 
ATOM   968  C CA  . TYR   A 1 126 ? -7.372  -26.773 18.922  1.000 38.335  0 126 TYR   A CA  1 ? 
ATOM   969  C C   . TYR   A 1 126 ? -8.849  -26.667 19.302  1.000 38.193  0 126 TYR   A C   1 ? 
ATOM   970  O O   . TYR   A 1 126 ? -9.681  -27.430 18.804  1.000 34.450  0 126 TYR   A O   1 ? 
ATOM   971  C CB  . TYR   A 1 126 ? -6.954  -25.695 17.913  1.000 39.087  0 126 TYR   A CB  1 ? 
ATOM   972  C CG  . TYR   A 1 126 ? -7.557  -25.839 16.525  1.000 36.689  0 126 TYR   A CG  1 ? 
ATOM   973  C CD1 . TYR   A 1 126 ? -8.849  -25.406 16.240  1.000 35.557  0 126 TYR   A CD1 1 ? 
ATOM   974  C CD2 . TYR   A 1 126 ? -6.835  -26.436 15.501  1.000 38.350  0 126 TYR   A CD2 1 ? 
ATOM   975  C CE1 . TYR   A 1 126 ? -9.396  -25.548 14.974  1.000 35.784  0 126 TYR   A CE1 1 ? 
ATOM   976  C CE2 . TYR   A 1 126 ? -7.370  -26.586 14.231  1.000 40.149  0 126 TYR   A CE2 1 ? 
ATOM   977  C CZ  . TYR   A 1 126 ? -8.654  -26.137 13.961  1.000 40.665  0 126 TYR   A CZ  1 ? 
ATOM   978  O OH  . TYR   A 1 126 ? -9.140  -26.291 12.682  1.000 44.424  0 126 TYR   A OH  1 ? 
ATOM   979  N N   . GLN   A 1 127 ? -9.146  -25.699 20.182  1.000 38.064  0 127 GLN   A N   1 ? 
ATOM   980  C CA  . GLN   A 1 127 ? -10.505 -25.411 20.611  1.000 43.952  0 127 GLN   A CA  1 ? 
ATOM   981  C C   . GLN   A 1 127 ? -11.037 -24.222 19.814  1.000 42.622  0 127 GLN   A C   1 ? 
ATOM   982  O O   . GLN   A 1 127 ? -10.292 -23.280 19.521  1.000 40.873  0 127 GLN   A O   1 ? 
ATOM   983  C CB  . GLN   A 1 127 ? -10.544 -25.101 22.111  1.000 50.198  0 127 GLN   A CB  1 ? 
ATOM   984  C CG  . GLN   A 1 127 ? -11.950 -25.032 22.707  1.000 56.122  0 127 GLN   A CG  1 ? 
ATOM   985  C CD  . GLN   A 1 127 ? -12.451 -26.294 23.376  1.000 59.717  0 127 GLN   A CD  1 ? 
ATOM   986  O OE1 . GLN   A 1 127 ? -13.585 -26.361 23.857  1.000 65.069  0 127 GLN   A OE1 1 ? 
ATOM   987  N NE2 . GLN   A 1 127 ? -11.611 -27.313 23.429  1.000 60.105  0 127 GLN   A NE2 1 ? 
ATOM   988  N N   . CYS   A 1 128 ? -12.323 -24.295 19.448  1.000 40.061  0 128 CYS   A N   1 ? 
ATOM   989  C CA  . CYS   A 1 128 ? -13.017 -23.148 18.887  1.000 45.041  0 128 CYS   A CA  1 ? 
ATOM   990  C C   . CYS   A 1 128 ? -14.503 -23.245 19.204  1.000 42.597  0 128 CYS   A C   1 ? 
ATOM   991  O O   . CYS   A 1 128 ? -14.953 -24.226 19.788  1.000 47.297  0 128 CYS   A O   1 ? 
ATOM   992  C CB  . CYS   A 1 128 ? -12.770 -22.953 17.386  1.000 51.042  0 128 CYS   A CB  1 ? 
ATOM   993  S SG  . CYS   A 1 128 ? -12.672 -24.459 16.394  1.000 47.164  0 128 CYS   A SG  1 ? 
ATOM   994  N N   . ALA   A 1 129 ? -15.247 -22.209 18.810  1.000 41.335  0 129 ALA   A N   1 ? 
ATOM   995  C CA  . ALA   A 1 129 ? -16.629 -22.045 19.222  1.000 43.720  0 129 ALA   A CA  1 ? 
ATOM   996  C C   . ALA   A 1 129 ? -17.536 -21.842 18.020  1.000 38.084  0 129 ALA   A C   1 ? 
ATOM   997  O O   . ALA   A 1 129 ? -17.120 -21.252 17.031  1.000 36.243  0 129 ALA   A O   1 ? 
ATOM   998  C CB  . ALA   A 1 129 ? -16.731 -20.854 20.144  1.000 48.513  0 129 ALA   A CB  1 ? 
ATOM   999  N N   . MET   A 1 130 ? -18.788 -22.290 18.157  1.000 39.161  0 130 MET   A N   1 ? 
ATOM   1000 C CA  . MET   A 1 130 ? -19.818 -22.002 17.173  1.000 44.522  0 130 MET   A CA  1 ? 
ATOM   1001 C C   . MET   A 1 130 ? -20.210 -20.531 17.284  1.000 45.013  0 130 MET   A C   1 ? 
ATOM   1002 O O   . MET   A 1 130 ? -21.040 -20.176 18.115  1.000 48.141  0 130 MET   A O   1 ? 
ATOM   1003 C CB  . MET   A 1 130 ? -21.067 -22.857 17.401  1.000 46.580  0 130 MET   A CB  1 ? 
ATOM   1004 C CG  . MET   A 1 130 ? -22.094 -22.715 16.298  1.000 49.763  0 130 MET   A CG  1 ? 
ATOM   1005 S SD  . MET   A 1 130 ? -21.371 -23.092 14.674  1.000 54.834  0 130 MET   A SD  1 ? 
ATOM   1006 C CE  . MET   A 1 130 ? -20.610 -24.684 14.992  1.000 50.940  0 130 MET   A CE  1 ? 
ATOM   1007 N N   . ARG   A 1 131 ? -19.614 -19.691 16.432  1.000 43.083  0 131 ARG   A N   1 ? 
ATOM   1008 C CA  . ARG   A 1 131 ? -19.826 -18.256 16.486  1.000 44.264  0 131 ARG   A CA  1 ? 
ATOM   1009 C C   . ARG   A 1 131 ? -21.310 -17.974 16.258  1.000 44.454  0 131 ARG   A C   1 ? 
ATOM   1010 O O   . ARG   A 1 131 ? -22.018 -18.787 15.665  1.000 42.692  0 131 ARG   A O   1 ? 
ATOM   1011 C CB  . ARG   A 1 131 ? -18.923 -17.577 15.452  1.000 47.221  0 131 ARG   A CB  1 ? 
ATOM   1012 C CG  . ARG   A 1 131 ? -17.447 -17.913 15.629  1.000 49.164  0 131 ARG   A CG  1 ? 
ATOM   1013 C CD  . ARG   A 1 131 ? -16.558 -16.779 16.092  1.000 48.500  0 131 ARG   A CD  1 ? 
ATOM   1014 N NE  . ARG   A 1 131 ? -17.283 -15.761 16.831  1.000 49.349  0 131 ARG   A NE  1 ? 
ATOM   1015 C CZ  . ARG   A 1 131 ? -17.256 -15.599 18.149  1.000 49.001  0 131 ARG   A CZ  1 ? 
ATOM   1016 N NH1 . ARG   A 1 131 ? -16.574 -16.435 18.914  1.000 48.767  0 131 ARG   A NH1 1 ? 
ATOM   1017 N NH2 . ARG   A 1 131 ? -17.930 -14.598 18.696  1.000 48.555  0 131 ARG   A NH2 1 ? 
ATOM   1018 N N   . PRO   A 1 132 ? -21.851 -16.835 16.743  1.000 46.567  0 132 PRO   A N   1 ? 
ATOM   1019 C CA  . PRO   A 1 132 ? -23.276 -16.543 16.576  1.000 49.685  0 132 PRO   A CA  1 ? 
ATOM   1020 C C   . PRO   A 1 132 ? -23.759 -16.539 15.129  1.000 54.166  0 132 PRO   A C   1 ? 
ATOM   1021 O O   . PRO   A 1 132 ? -24.950 -16.743 14.903  1.000 58.053  0 132 PRO   A O   1 ? 
ATOM   1022 C CB  . PRO   A 1 132 ? -23.412 -15.153 17.205  1.000 48.941  0 132 PRO   A CB  1 ? 
ATOM   1023 C CG  . PRO   A 1 132 ? -22.314 -15.139 18.240  1.000 46.092  0 132 PRO   A CG  1 ? 
ATOM   1024 C CD  . PRO   A 1 132 ? -21.158 -15.806 17.528  1.000 45.440  0 132 PRO   A CD  1 ? 
ATOM   1025 N N   . ASN   A 1 133 ? -22.832 -16.330 14.173  1.000 52.147  0 133 ASN   A N   1 ? 
ATOM   1026 C CA  . ASN   A 1 133 ? -23.158 -16.360 12.751  1.000 53.202  0 133 ASN   A CA  1 ? 
ATOM   1027 C C   . ASN   A 1 133 ? -23.072 -17.780 12.191  1.000 50.844  0 133 ASN   A C   1 ? 
ATOM   1028 O O   . ASN   A 1 133 ? -23.326 -17.978 11.007  1.000 53.027  0 133 ASN   A O   1 ? 
ATOM   1029 C CB  . ASN   A 1 133 ? -22.281 -15.412 11.923  1.000 52.967  0 133 ASN   A CB  1 ? 
ATOM   1030 C CG  . ASN   A 1 133 ? -20.806 -15.727 12.007  1.000 54.277  0 133 ASN   A CG  1 ? 
ATOM   1031 O OD1 . ASN   A 1 133 ? -20.421 -16.753 12.569  1.000 57.091  0 133 ASN   A OD1 1 ? 
ATOM   1032 N ND2 . ASN   A 1 133 ? -19.984 -14.848 11.453  1.000 51.725  0 133 ASN   A ND2 1 ? 
ATOM   1033 N N   . PHE   A 1 134 ? -22.709 -18.751 13.037  1.000 52.326  0 134 PHE   A N   1 ? 
ATOM   1034 C CA  . PHE   A 1 134 ? -22.743 -20.173 12.700  1.000 52.285  0 134 PHE   A CA  1 ? 
ATOM   1035 C C   . PHE   A 1 134 ? -21.538 -20.556 11.844  1.000 43.230  0 134 PHE   A C   1 ? 
ATOM   1036 O O   . PHE   A 1 134 ? -21.581 -21.509 11.070  1.000 39.955  0 134 PHE   A O   1 ? 
ATOM   1037 C CB  . PHE   A 1 134 ? -24.079 -20.560 12.056  1.000 53.919  0 134 PHE   A CB  1 ? 
ATOM   1038 C CG  . PHE   A 1 134 ? -25.240 -20.544 13.017  1.000 55.567  0 134 PHE   A CG  1 ? 
ATOM   1039 C CD1 . PHE   A 1 134 ? -25.375 -21.544 13.971  1.000 53.913  0 134 PHE   A CD1 1 ? 
ATOM   1040 C CD2 . PHE   A 1 134 ? -26.174 -19.516 12.994  1.000 56.813  0 134 PHE   A CD2 1 ? 
ATOM   1041 C CE1 . PHE   A 1 134 ? -26.437 -21.539 14.860  1.000 54.632  0 134 PHE   A CE1 1 ? 
ATOM   1042 C CE2 . PHE   A 1 134 ? -27.232 -19.508 13.890  1.000 57.892  0 134 PHE   A CE2 1 ? 
ATOM   1043 C CZ  . PHE   A 1 134 ? -27.361 -20.521 14.819  1.000 58.185  0 134 PHE   A CZ  1 ? 
ATOM   1044 N N   . THR   A 1 135 ? -20.453 -19.814 12.036  1.000 39.356  0 135 THR   A N   1 ? 
ATOM   1045 C CA  . THR   A 1 135 ? -19.176 -20.124 11.431  1.000 39.329  0 135 THR   A CA  1 ? 
ATOM   1046 C C   . THR   A 1 135 ? -18.246 -20.542 12.555  1.000 36.703  0 135 THR   A C   1 ? 
ATOM   1047 O O   . THR   A 1 135 ? -18.708 -20.655 13.680  1.000 40.705  0 135 THR   A O   1 ? 
ATOM   1048 C CB  . THR   A 1 135 ? -18.655 -18.903 10.671  1.000 40.541  0 135 THR   A CB  1 ? 
ATOM   1049 O OG1 . THR   A 1 135 ? -18.237 -17.933 11.633  1.000 40.523  0 135 THR   A OG1 1 ? 
ATOM   1050 C CG2 . THR   A 1 135 ? -19.700 -18.335 9.734   1.000 39.792  0 135 THR   A CG2 1 ? 
ATOM   1051 N N   . ILE   A 1 136 ? -16.962 -20.744 12.258  1.000 35.028  0 136 ILE   A N   1 ? 
ATOM   1052 C CA  . ILE   A 1 136 ? -15.964 -21.018 13.283  1.000 38.024  0 136 ILE   A CA  1 ? 
ATOM   1053 C C   . ILE   A 1 136 ? -14.629 -20.476 12.801  1.000 35.028  0 136 ILE   A C   1 ? 
ATOM   1054 O O   . ILE   A 1 136 ? -14.333 -20.535 11.622  1.000 37.370  0 136 ILE   A O   1 ? 
ATOM   1055 C CB  . ILE   A 1 136 ? -15.844 -22.523 13.633  1.000 44.105  0 136 ILE   A CB  1 ? 
ATOM   1056 C CG1 . ILE   A 1 136 ? -15.287 -23.374 12.484  1.000 43.470  0 136 ILE   A CG1 1 ? 
ATOM   1057 C CG2 . ILE   A 1 136 ? -17.165 -23.098 14.139  1.000 46.821  0 136 ILE   A CG2 1 ? 
ATOM   1058 C CD1 . ILE   A 1 136 ? -14.654 -24.685 12.937  1.000 41.359  0 136 ILE   A CD1 1 ? 
ATOM   1059 N N   . LYS   A 1 137 ? -13.814 -19.968 13.715  1.000 38.916  0 137 LYS   A N   1 ? 
ATOM   1060 C CA  . LYS   A 1 137 ? -12.538 -19.414 13.313  1.000 44.488  0 137 LYS   A CA  1 ? 
ATOM   1061 C C   . LYS   A 1 137 ? -11.530 -20.533 13.497  1.000 43.722  0 137 LYS   A C   1 ? 
ATOM   1062 O O   . LYS   A 1 137 ? -10.974 -20.705 14.576  1.000 43.739  0 137 LYS   A O   1 ? 
ATOM   1063 C CB  . LYS   A 1 137 ? -12.201 -18.133 14.082  1.000 51.261  0 137 LYS   A CB  1 ? 
ATOM   1064 C CG  . LYS   A 1 137 ? -13.372 -17.174 14.267  1.000 54.705  0 137 LYS   A CG  1 ? 
ATOM   1065 C CD  . LYS   A 1 137 ? -13.017 -15.699 14.243  1.000 58.325  0 137 LYS   A CD  1 ? 
ATOM   1066 C CE  . LYS   A 1 137 ? -12.840 -15.171 12.834  1.000 64.168  0 137 LYS   A CE  1 ? 
ATOM   1067 N NZ  . LYS   A 1 137 ? -13.066 -13.709 12.754  1.000 65.597  0 137 LYS   A NZ  1 ? 
ATOM   1068 N N   . GLY   A 1 138 ? -11.377 -21.311 12.423  1.000 45.237  0 138 GLY   A N   1 ? 
ATOM   1069 C CA  . GLY   A 1 138 ? -10.567 -22.512 12.422  1.000 44.864  0 138 GLY   A CA  1 ? 
ATOM   1070 C C   . GLY   A 1 138 ? -9.297  -22.348 11.595  1.000 43.000  0 138 GLY   A C   1 ? 
ATOM   1071 O O   . GLY   A 1 138 ? -8.961  -21.261 11.143  1.000 44.742  0 138 GLY   A O   1 ? 
ATOM   1072 N N   . SER   A 1 139 ? -8.580  -23.456 11.448  1.000 42.879  0 139 SER   A N   1 ? 
ATOM   1073 C CA  . SER   A 1 139 ? -7.407  -23.534 10.604  1.000 39.583  0 139 SER   A CA  1 ? 
ATOM   1074 C C   . SER   A 1 139 ? -7.526  -24.808 9.780   1.000 37.003  0 139 SER   A C   1 ? 
ATOM   1075 O O   . SER   A 1 139 ? -7.313  -25.895 10.309  1.000 37.927  0 139 SER   A O   1 ? 
ATOM   1076 C CB  . SER   A 1 139 ? -6.164  -23.503 11.431  1.000 37.720  0 139 SER   A CB  1 ? 
ATOM   1077 O OG  . SER   A 1 139 ? -5.046  -23.823 10.628  1.000 42.463  0 139 SER   A OG  1 ? 
ATOM   1078 N N   . PHE   A 1 140 ? -7.943  -24.660 8.514   1.000 35.849  0 140 PHE   A N   1 ? 
ATOM   1079 C CA  . PHE   A 1 140 ? -8.278  -25.802 7.684   1.000 36.120  0 140 PHE   A CA  1 ? 
ATOM   1080 C C   . PHE   A 1 140 ? -7.737  -25.625 6.273   1.000 39.229  0 140 PHE   A C   1 ? 
ATOM   1081 O O   . PHE   A 1 140 ? -8.254  -24.808 5.520   1.000 41.687  0 140 PHE   A O   1 ? 
ATOM   1082 C CB  . PHE   A 1 140 ? -9.790  -25.968 7.599   1.000 36.238  0 140 PHE   A CB  1 ? 
ATOM   1083 C CG  . PHE   A 1 140 ? -10.454 -26.387 8.881   1.000 36.492  0 140 PHE   A CG  1 ? 
ATOM   1084 C CD1 . PHE   A 1 140 ? -10.366 -27.688 9.339   1.000 39.172  0 140 PHE   A CD1 1 ? 
ATOM   1085 C CD2 . PHE   A 1 140 ? -11.172 -25.478 9.633   1.000 38.813  0 140 PHE   A CD2 1 ? 
ATOM   1086 C CE1 . PHE   A 1 140 ? -11.000 -28.078 10.510  1.000 38.460  0 140 PHE   A CE1 1 ? 
ATOM   1087 C CE2 . PHE   A 1 140 ? -11.800 -25.863 10.808  1.000 40.560  0 140 PHE   A CE2 1 ? 
ATOM   1088 C CZ  . PHE   A 1 140 ? -11.719 -27.164 11.243  1.000 38.001  0 140 PHE   A CZ  1 ? 
ATOM   1089 N N   . LEU   A 1 141 ? -6.720  -26.424 5.919   1.000 41.019  0 141 LEU   A N   1 ? 
ATOM   1090 C CA  . LEU   A 1 141 ? -6.200  -26.467 4.566   1.000 38.790  0 141 LEU   A CA  1 ? 
ATOM   1091 C C   . LEU   A 1 141 ? -7.008  -27.469 3.758   1.000 42.038  0 141 LEU   A C   1 ? 
ATOM   1092 O O   . LEU   A 1 141 ? -7.878  -28.150 4.294   1.000 39.519  0 141 LEU   A O   1 ? 
ATOM   1093 C CB  . LEU   A 1 141 ? -4.728  -26.870 4.607   1.000 38.963  0 141 LEU   A CB  1 ? 
ATOM   1094 C CG  . LEU   A 1 141 ? -3.831  -25.912 5.381   1.000 42.595  0 141 LEU   A CG  1 ? 
ATOM   1095 C CD1 . LEU   A 1 141 ? -2.382  -26.342 5.274   1.000 43.971  0 141 LEU   A CD1 1 ? 
ATOM   1096 C CD2 . LEU   A 1 141 ? -3.999  -24.476 4.890   1.000 42.893  0 141 LEU   A CD2 1 ? 
ATOM   1097 N N   . ASN   A 1 142 ? -6.702  -27.540 2.457   1.000 46.864  0 142 ASN   A N   1 ? 
ATOM   1098 C CA  . ASN   A 1 142 ? -7.304  -28.541 1.599   1.000 45.387  0 142 ASN   A CA  1 ? 
ATOM   1099 C C   . ASN   A 1 142 ? -6.872  -29.922 2.089   1.000 40.707  0 142 ASN   A C   1 ? 
ATOM   1100 O O   . ASN   A 1 142 ? -5.731  -30.124 2.521   1.000 34.452  0 142 ASN   A O   1 ? 
ATOM   1101 C CB  . ASN   A 1 142 ? -6.987  -28.324 0.119   1.000 46.212  0 142 ASN   A CB  1 ? 
ATOM   1102 C CG  . ASN   A 1 142 ? -8.020  -29.010 -0.748  1.000 50.467  0 142 ASN   A CG  1 ? 
ATOM   1103 O OD1 . ASN   A 1 142 ? -7.746  -30.040 -1.365  1.000 47.384  0 142 ASN   A OD1 1 ? 
ATOM   1104 N ND2 . ASN   A 1 142 ? -9.232  -28.477 -0.738  1.000 51.071  0 142 ASN   A ND2 1 ? 
ATOM   1105 N N   . GLY   A 1 143 ? -7.830  -30.851 2.052   1.000 39.777  0 143 GLY   A N   1 ? 
ATOM   1106 C CA  . GLY   A 1 143 ? -7.650  -32.159 2.658   1.000 42.859  0 143 GLY   A CA  1 ? 
ATOM   1107 C C   . GLY   A 1 143 ? -8.160  -32.229 4.099   1.000 44.506  0 143 GLY   A C   1 ? 
ATOM   1108 O O   . GLY   A 1 143 ? -8.160  -33.309 4.689   1.000 47.087  0 143 GLY   A O   1 ? 
ATOM   1109 N N   . SER   A 1 144 ? -8.590  -31.093 4.671   1.000 41.239  0 144 SER   A N   1 ? 
ATOM   1110 C CA  . SER   A 1 144 ? -8.957  -31.072 6.078   1.000 39.934  0 144 SER   A CA  1 ? 
ATOM   1111 C C   . SER   A 1 144 ? -10.374 -31.610 6.278   1.000 39.009  0 144 SER   A C   1 ? 
ATOM   1112 O O   . SER   A 1 144 ? -10.756 -31.958 7.396   1.000 35.807  0 144 SER   A O   1 ? 
ATOM   1113 C CB  . SER   A 1 144 ? -8.848  -29.698 6.642   1.000 38.652  0 144 SER   A CB  1 ? 
ATOM   1114 O OG  . SER   A 1 144 ? -10.008 -28.941 6.313   1.000 36.767  0 144 SER   A OG  1 ? 
ATOM   1115 N N   . CYS   A 1 145 ? -11.163 -31.634 5.200   1.000 39.526  0 145 CYS   A N   1 ? 
ATOM   1116 C CA  . CYS   A 1 145 ? -12.586 -31.919 5.309   1.000 42.227  0 145 CYS   A CA  1 ? 
ATOM   1117 C C   . CYS   A 1 145 ? -12.855 -33.229 6.037   1.000 40.166  0 145 CYS   A C   1 ? 
ATOM   1118 O O   . CYS   A 1 145 ? -12.079 -34.182 5.957   1.000 36.788  0 145 CYS   A O   1 ? 
ATOM   1119 C CB  . CYS   A 1 145 ? -13.257 -31.991 3.948   1.000 43.458  0 145 CYS   A CB  1 ? 
ATOM   1120 S SG  . CYS   A 1 145 ? -13.602 -30.349 3.283   1.000 48.217  0 145 CYS   A SG  1 ? 
ATOM   1121 N N   . GLY   A 1 146 ? -13.993 -33.248 6.732   1.000 39.662  0 146 GLY   A N   1 ? 
ATOM   1122 C CA  . GLY   A 1 146 ? -14.450 -34.428 7.444   1.000 39.286  0 146 GLY   A CA  1 ? 
ATOM   1123 C C   . GLY   A 1 146 ? -13.792 -34.588 8.813   1.000 34.200  0 146 GLY   A C   1 ? 
ATOM   1124 O O   . GLY   A 1 146 ? -14.214 -35.445 9.588   1.000 29.939  0 146 GLY   A O   1 ? 
ATOM   1125 N N   . SER   A 1 147 ? -12.728 -33.806 9.064   1.000 31.366  0 147 SER   A N   1 ? 
ATOM   1126 C CA  . SER   A 1 147 ? -12.234 -33.578 10.408  1.000 33.285  0 147 SER   A CA  1 ? 
ATOM   1127 C C   . SER   A 1 147 ? -13.407 -33.155 11.285  1.000 36.757  0 147 SER   A C   1 ? 
ATOM   1128 O O   . SER   A 1 147 ? -14.406 -32.659 10.753  1.000 40.826  0 147 SER   A O   1 ? 
ATOM   1129 C CB  . SER   A 1 147 ? -11.142 -32.558 10.407  1.000 32.133  0 147 SER   A CB  1 ? 
ATOM   1130 O OG  . SER   A 1 147 ? -10.034 -33.045 9.677   1.000 32.374  0 147 SER   A OG  1 ? 
ATOM   1131 N N   . VAL   A 1 148 ? -13.307 -33.378 12.609  1.000 37.498  0 148 VAL   A N   1 ? 
ATOM   1132 C CA  . VAL   A 1 148 ? -14.480 -33.237 13.469  1.000 37.800  0 148 VAL   A CA  1 ? 
ATOM   1133 C C   . VAL   A 1 148 ? -14.199 -32.402 14.711  1.000 36.972  0 148 VAL   A C   1 ? 
ATOM   1134 O O   . VAL   A 1 148 ? -13.051 -32.262 15.162  1.000 33.629  0 148 VAL   A O   1 ? 
ATOM   1135 C CB  . VAL   A 1 148 ? -15.044 -34.594 13.916  1.000 38.809  0 148 VAL   A CB  1 ? 
ATOM   1136 C CG1 . VAL   A 1 148 ? -15.802 -35.289 12.796  1.000 39.611  0 148 VAL   A CG1 1 ? 
ATOM   1137 C CG2 . VAL   A 1 148 ? -13.946 -35.474 14.497  1.000 39.659  0 148 VAL   A CG2 1 ? 
ATOM   1138 N N   . GLY   A 1 149 ? -15.324 -31.929 15.270  1.000 35.971  0 149 GLY   A N   1 ? 
ATOM   1139 C CA  . GLY   A 1 149 ? -15.363 -31.172 16.509  1.000 36.355  0 149 GLY   A CA  1 ? 
ATOM   1140 C C   . GLY   A 1 149 ? -16.068 -31.950 17.615  1.000 35.243  0 149 GLY   A C   1 ? 
ATOM   1141 O O   . GLY   A 1 149 ? -17.134 -32.531 17.420  1.000 31.626  0 149 GLY   A O   1 ? 
ATOM   1142 N N   . PHE   A 1 150 ? -15.463 -31.958 18.796  1.000 37.512  0 150 PHE   A N   1 ? 
ATOM   1143 C CA  . PHE   A 1 150 ? -15.948 -32.850 19.827  1.000 43.062  0 150 PHE   A CA  1 ? 
ATOM   1144 C C   . PHE   A 1 150 ? -15.721 -32.272 21.219  1.000 46.232  0 150 PHE   A C   1 ? 
ATOM   1145 O O   . PHE   A 1 150 ? -14.812 -31.471 21.437  1.000 46.522  0 150 PHE   A O   1 ? 
ATOM   1146 C CB  . PHE   A 1 150 ? -15.253 -34.207 19.729  1.000 43.760  0 150 PHE   A CB  1 ? 
ATOM   1147 C CG  . PHE   A 1 150 ? -13.758 -34.155 19.920  1.000 42.403  0 150 PHE   A CG  1 ? 
ATOM   1148 C CD1 . PHE   A 1 150 ? -12.923 -33.704 18.905  1.000 42.499  0 150 PHE   A CD1 1 ? 
ATOM   1149 C CD2 . PHE   A 1 150 ? -13.180 -34.550 21.115  1.000 41.325  0 150 PHE   A CD2 1 ? 
ATOM   1150 C CE1 . PHE   A 1 150 ? -11.546 -33.660 19.076  1.000 40.504  0 150 PHE   A CE1 1 ? 
ATOM   1151 C CE2 . PHE   A 1 150 ? -11.803 -34.501 21.287  1.000 41.440  0 150 PHE   A CE2 1 ? 
ATOM   1152 C CZ  . PHE   A 1 150 ? -10.988 -34.057 20.269  1.000 41.409  0 150 PHE   A CZ  1 ? 
ATOM   1153 N N   . ASN   A 1 151 ? -16.591 -32.711 22.134  1.000 46.760  0 151 ASN   A N   1 ? 
ATOM   1154 C CA  . ASN   A 1 151 ? -16.432 -32.533 23.563  1.000 47.988  0 151 ASN   A CA  1 ? 
ATOM   1155 C C   . ASN   A 1 151 ? -16.331 -33.905 24.218  1.000 51.559  0 151 ASN   A C   1 ? 
ATOM   1156 O O   . ASN   A 1 151 ? -16.717 -34.924 23.640  1.000 50.029  0 151 ASN   A O   1 ? 
ATOM   1157 C CB  . ASN   A 1 151 ? -17.598 -31.747 24.164  1.000 47.758  0 151 ASN   A CB  1 ? 
ATOM   1158 C CG  . ASN   A 1 151 ? -17.581 -30.282 23.780  1.000 46.141  0 151 ASN   A CG  1 ? 
ATOM   1159 O OD1 . ASN   A 1 151 ? -16.683 -29.547 24.180  1.000 47.103  0 151 ASN   A OD1 1 ? 
ATOM   1160 N ND2 . ASN   A 1 151 ? -18.575 -29.841 23.026  1.000 44.098  0 151 ASN   A ND2 1 ? 
ATOM   1161 N N   . ILE   A 1 152 ? -15.809 -33.907 25.444  1.000 58.130  0 152 ILE   A N   1 ? 
ATOM   1162 C CA  . ILE   A 1 152 ? -15.694 -35.120 26.233  1.000 58.552  0 152 ILE   A CA  1 ? 
ATOM   1163 C C   . ILE   A 1 152 ? -16.303 -34.849 27.606  1.000 60.132  0 152 ILE   A C   1 ? 
ATOM   1164 O O   . ILE   A 1 152 ? -16.105 -33.771 28.159  1.000 53.246  0 152 ILE   A O   1 ? 
ATOM   1165 C CB  . ILE   A 1 152 ? -14.225 -35.585 26.304  1.000 57.729  0 152 ILE   A CB  1 ? 
ATOM   1166 C CG1 . ILE   A 1 152 ? -13.544 -35.531 24.931  1.000 57.505  0 152 ILE   A CG1 1 ? 
ATOM   1167 C CG2 . ILE   A 1 152 ? -14.137 -36.968 26.930  1.000 58.276  0 152 ILE   A CG2 1 ? 
ATOM   1168 C CD1 . ILE   A 1 152 ? -12.126 -36.070 24.908  1.000 59.300  0 152 ILE   A CD1 1 ? 
ATOM   1169 N N   . ASP   A 1 153 ? -17.057 -35.842 28.110  1.000 76.269  0 153 ASP   A N   1 ? 
ATOM   1170 C CA  . ASP   A 1 153 ? -17.744 -35.816 29.399  1.000 79.335  0 153 ASP   A CA  1 ? 
ATOM   1171 C C   . ASP   A 1 153 ? -17.275 -37.025 30.213  1.000 76.263  0 153 ASP   A C   1 ? 
ATOM   1172 O O   . ASP   A 1 153 ? -18.006 -37.998 30.391  1.000 71.856  0 153 ASP   A O   1 ? 
ATOM   1173 C CB  . ASP   A 1 153 ? -19.268 -35.843 29.219  1.000 86.029  0 153 ASP   A CB  1 ? 
ATOM   1174 C CG  . ASP   A 1 153 ? -19.723 -35.322 27.865  1.000 97.864  0 153 ASP   A CG  1 ? 
ATOM   1175 O OD1 . ASP   A 1 153 ? -19.469 -34.133 27.581  1.000 99.920  0 153 ASP   A OD1 1 ? 
ATOM   1176 O OD2 . ASP   A 1 153 ? -20.294 -36.124 27.087  1.000 101.573 0 153 ASP   A OD2 1 ? 
ATOM   1177 N N   . TYR   A 1 154 ? -16.033 -36.933 30.700  1.000 77.990  0 154 TYR   A N   1 ? 
ATOM   1178 C CA  . TYR   A 1 154 ? -15.284 -38.032 31.292  1.000 82.224  0 154 TYR   A CA  1 ? 
ATOM   1179 C C   . TYR   A 1 154 ? -14.993 -39.105 30.240  1.000 77.787  0 154 TYR   A C   1 ? 
ATOM   1180 O O   . TYR   A 1 154 ? -13.888 -39.172 29.704  1.000 67.936  0 154 TYR   A O   1 ? 
ATOM   1181 C CB  . TYR   A 1 154 ? -15.957 -38.621 32.537  1.000 89.951  0 154 TYR   A CB  1 ? 
ATOM   1182 C CG  . TYR   A 1 154 ? -15.241 -39.870 33.029  1.000 98.760  0 154 TYR   A CG  1 ? 
ATOM   1183 C CD1 . TYR   A 1 154 ? -13.894 -39.825 33.375  1.000 105.467 0 154 TYR   A CD1 1 ? 
ATOM   1184 C CD2 . TYR   A 1 154 ? -15.889 -41.100 33.090  1.000 99.276  0 154 TYR   A CD2 1 ? 
ATOM   1185 C CE1 . TYR   A 1 154 ? -13.221 -40.960 33.797  1.000 107.543 0 154 TYR   A CE1 1 ? 
ATOM   1186 C CE2 . TYR   A 1 154 ? -15.227 -42.242 33.512  1.000 102.105 0 154 TYR   A CE2 1 ? 
ATOM   1187 C CZ  . TYR   A 1 154 ? -13.889 -42.172 33.868  1.000 103.340 0 154 TYR   A CZ  1 ? 
ATOM   1188 O OH  . TYR   A 1 154 ? -13.225 -43.290 34.287  1.000 94.502  0 154 TYR   A OH  1 ? 
ATOM   1189 N N   . ASP   A 1 155 ? -15.977 -39.970 29.977  1.000 76.552  0 155 ASP   A N   1 ? 
ATOM   1190 C CA  . ASP   A 1 155 ? -15.811 -41.053 29.019  1.000 80.074  0 155 ASP   A CA  1 ? 
ATOM   1191 C C   . ASP   A 1 155 ? -16.407 -40.628 27.675  1.000 77.508  0 155 ASP   A C   1 ? 
ATOM   1192 O O   . ASP   A 1 155 ? -15.714 -40.658 26.660  1.000 77.284  0 155 ASP   A O   1 ? 
ATOM   1193 C CB  . ASP   A 1 155 ? -16.391 -42.369 29.555  1.000 79.198  0 155 ASP   A CB  1 ? 
ATOM   1194 C CG  . ASP   A 1 155 ? -17.711 -42.247 30.303  1.000 78.054  0 155 ASP   A CG  1 ? 
ATOM   1195 O OD1 . ASP   A 1 155 ? -18.153 -41.104 30.546  1.000 79.262  0 155 ASP   A OD1 1 ? 
ATOM   1196 O OD2 . ASP   A 1 155 ? -18.281 -43.297 30.647  1.000 74.689  0 155 ASP   A OD2 1 ? 
ATOM   1197 N N   . CYS   A 1 156 ? -17.668 -40.169 27.712  1.000 69.105  0 156 CYS   A N   1 ? 
ATOM   1198 C CA  . CYS   A 1 156 ? -18.509 -39.973 26.542  1.000 60.262  0 156 CYS   A CA  1 ? 
ATOM   1199 C C   . CYS   A 1 156 ? -17.989 -38.843 25.645  1.000 56.685  0 156 CYS   A C   1 ? 
ATOM   1200 O O   . CYS   A 1 156 ? -17.810 -37.718 26.109  1.000 50.182  0 156 CYS   A O   1 ? 
ATOM   1201 C CB  . CYS   A 1 156 ? -19.926 -39.666 27.006  1.000 58.499  0 156 CYS   A CB  1 ? 
ATOM   1202 S SG  . CYS   A 1 156 ? -21.157 -39.797 25.688  1.000 62.011  0 156 CYS   A SG  1 ? 
ATOM   1203 N N   . VAL   A 1 157 ? -17.786 -39.152 24.349  1.000 53.645  0 157 VAL   A N   1 ? 
ATOM   1204 C CA  . VAL   A 1 157 ? -17.318 -38.195 23.354  1.000 50.279  0 157 VAL   A CA  1 ? 
ATOM   1205 C C   . VAL   A 1 157 ? -18.521 -37.670 22.578  1.000 49.541  0 157 VAL   A C   1 ? 
ATOM   1206 O O   . VAL   A 1 157 ? -19.232 -38.445 21.949  1.000 49.965  0 157 VAL   A O   1 ? 
ATOM   1207 C CB  . VAL   A 1 157 ? -16.289 -38.819 22.386  1.000 47.961  0 157 VAL   A CB  1 ? 
ATOM   1208 C CG1 . VAL   A 1 157 ? -15.740 -37.788 21.405  1.000 47.831  0 157 VAL   A CG1 1 ? 
ATOM   1209 C CG2 . VAL   A 1 157 ? -15.148 -39.503 23.122  1.000 46.783  0 157 VAL   A CG2 1 ? 
ATOM   1210 N N   . SER   A 1 158 ? -18.727 -36.352 22.607  1.000 49.207  0 158 SER   A N   1 ? 
ATOM   1211 C CA  . SER   A 1 158 ? -19.872 -35.752 21.944  1.000 50.714  0 158 SER   A CA  1 ? 
ATOM   1212 C C   . SER   A 1 158 ? -19.428 -35.114 20.638  1.000 51.818  0 158 SER   A C   1 ? 
ATOM   1213 O O   . SER   A 1 158 ? -18.549 -34.259 20.635  1.000 56.444  0 158 SER   A O   1 ? 
ATOM   1214 C CB  . SER   A 1 158 ? -20.543 -34.746 22.820  1.000 51.012  0 158 SER   A CB  1 ? 
ATOM   1215 O OG  . SER   A 1 158 ? -21.293 -35.409 23.821  1.000 57.676  0 158 SER   A OG  1 ? 
ATOM   1216 N N   . PHE   A 1 159 ? -20.061 -35.520 19.537  1.000 47.649  0 159 PHE   A N   1 ? 
ATOM   1217 C CA  . PHE   A 1 159 ? -19.638 -35.064 18.227  1.000 44.276  0 159 PHE   A CA  1 ? 
ATOM   1218 C C   . PHE   A 1 159 ? -20.578 -33.953 17.768  1.000 44.196  0 159 PHE   A C   1 ? 
ATOM   1219 O O   . PHE   A 1 159 ? -21.779 -34.156 17.578  1.000 44.448  0 159 PHE   A O   1 ? 
ATOM   1220 C CB  . PHE   A 1 159 ? -19.544 -36.255 17.271  1.000 42.612  0 159 PHE   A CB  1 ? 
ATOM   1221 C CG  . PHE   A 1 159 ? -18.370 -37.171 17.523  1.000 39.028  0 159 PHE   A CG  1 ? 
ATOM   1222 C CD1 . PHE   A 1 159 ? -17.084 -36.790 17.173  1.000 37.923  0 159 PHE   A CD1 1 ? 
ATOM   1223 C CD2 . PHE   A 1 159 ? -18.541 -38.410 18.122  1.000 37.950  0 159 PHE   A CD2 1 ? 
ATOM   1224 C CE1 . PHE   A 1 159 ? -16.003 -37.632 17.398  1.000 37.845  0 159 PHE   A CE1 1 ? 
ATOM   1225 C CE2 . PHE   A 1 159 ? -17.457 -39.248 18.352  1.000 37.219  0 159 PHE   A CE2 1 ? 
ATOM   1226 C CZ  . PHE   A 1 159 ? -16.189 -38.862 17.986  1.000 36.028  0 159 PHE   A CZ  1 ? 
ATOM   1227 N N   . CYS   A 1 160 ? -19.999 -32.763 17.604  1.000 43.784  0 160 CYS   A N   1 ? 
ATOM   1228 C CA  . CYS   A 1 160 ? -20.785 -31.565 17.384  1.000 44.756  0 160 CYS   A CA  1 ? 
ATOM   1229 C C   . CYS   A 1 160 ? -20.587 -31.019 15.971  1.000 44.887  0 160 CYS   A C   1 ? 
ATOM   1230 O O   . CYS   A 1 160 ? -21.420 -30.247 15.502  1.000 44.297  0 160 CYS   A O   1 ? 
ATOM   1231 C CB  . CYS   A 1 160 ? -20.451 -30.501 18.423  1.000 45.234  0 160 CYS   A CB  1 ? 
ATOM   1232 S SG  . CYS   A 1 160 ? -18.680 -30.335 18.754  1.000 47.866  0 160 CYS   A SG  1 ? 
ATOM   1233 N N   . TYR   A 1 161 ? -19.509 -31.427 15.289  1.000 42.359  0 161 TYR   A N   1 ? 
ATOM   1234 C CA  . TYR   A 1 161 ? -19.124 -30.772 14.049  1.000 39.233  0 161 TYR   A CA  1 ? 
ATOM   1235 C C   . TYR   A 1 161 ? -18.472 -31.776 13.125  1.000 34.464  0 161 TYR   A C   1 ? 
ATOM   1236 O O   . TYR   A 1 161 ? -17.781 -32.673 13.598  1.000 30.957  0 161 TYR   A O   1 ? 
ATOM   1237 C CB  . TYR   A 1 161 ? -18.101 -29.663 14.305  1.000 40.720  0 161 TYR   A CB  1 ? 
ATOM   1238 C CG  . TYR   A 1 161 ? -17.629 -28.838 13.113  1.000 41.042  0 161 TYR   A CG  1 ? 
ATOM   1239 C CD1 . TYR   A 1 161 ? -18.475 -27.937 12.469  1.000 42.052  0 161 TYR   A CD1 1 ? 
ATOM   1240 C CD2 . TYR   A 1 161 ? -16.313 -28.910 12.666  1.000 41.892  0 161 TYR   A CD2 1 ? 
ATOM   1241 C CE1 . TYR   A 1 161 ? -18.033 -27.151 11.412  1.000 40.594  0 161 TYR   A CE1 1 ? 
ATOM   1242 C CE2 . TYR   A 1 161 ? -15.860 -28.128 11.610  1.000 38.946  0 161 TYR   A CE2 1 ? 
ATOM   1243 C CZ  . TYR   A 1 161 ? -16.719 -27.243 10.985  1.000 38.734  0 161 TYR   A CZ  1 ? 
ATOM   1244 O OH  . TYR   A 1 161 ? -16.273 -26.490 9.934   1.000 40.867  0 161 TYR   A OH  1 ? 
ATOM   1245 N N   . MET   A 1 162 ? -18.717 -31.581 11.825  1.000 35.358  0 162 MET   A N   1 ? 
ATOM   1246 C CA  . MET   A 1 162 ? -17.886 -32.141 10.771  1.000 35.305  0 162 MET   A CA  1 ? 
ATOM   1247 C C   . MET   A 1 162 ? -17.608 -31.049 9.752   1.000 32.218  0 162 MET   A C   1 ? 
ATOM   1248 O O   . MET   A 1 162 ? -18.527 -30.350 9.351   1.000 31.661  0 162 MET   A O   1 ? 
ATOM   1249 C CB  . MET   A 1 162 ? -18.572 -33.292 10.044  1.000 36.603  0 162 MET   A CB  1 ? 
ATOM   1250 C CG  . MET   A 1 162 ? -17.811 -33.727 8.801   1.000 37.393  0 162 MET   A CG  1 ? 
ATOM   1251 S SD  . MET   A 1 162 ? -18.355 -35.359 8.253   1.000 34.641  0 162 MET   A SD  1 ? 
ATOM   1252 C CE  . MET   A 1 162 ? -16.927 -36.304 8.784   1.000 34.434  0 162 MET   A CE  1 ? 
ATOM   1253 N N   . HIS   A 1 163 ? -16.349 -30.934 9.333   1.000 30.804  0 163 HIS   A N   1 ? 
ATOM   1254 C CA  . HIS   A 1 163 ? -15.895 -29.797 8.548   1.000 32.221  0 163 HIS   A CA  1 ? 
ATOM   1255 C C   . HIS   A 1 163 ? -16.168 -30.009 7.061   1.000 35.624  0 163 HIS   A C   1 ? 
ATOM   1256 O O   . HIS   A 1 163 ? -15.970 -31.117 6.551   1.000 38.867  0 163 HIS   A O   1 ? 
ATOM   1257 C CB  . HIS   A 1 163 ? -14.394 -29.583 8.746   1.000 31.617  0 163 HIS   A CB  1 ? 
ATOM   1258 C CG  . HIS   A 1 163 ? -13.886 -28.453 7.938   1.000 30.476  0 163 HIS   A CG  1 ? 
ATOM   1259 N ND1 . HIS   A 1 163 ? -14.230 -27.144 8.195   1.000 29.438  0 163 HIS   A ND1 1 ? 
ATOM   1260 C CD2 . HIS   A 1 163 ? -13.078 -28.445 6.874   1.000 29.853  0 163 HIS   A CD2 1 ? 
ATOM   1261 C CE1 . HIS   A 1 163 ? -13.640 -26.376 7.294   1.000 31.656  0 163 HIS   A CE1 1 ? 
ATOM   1262 N NE2 . HIS   A 1 163 ? -12.941 -27.146 6.484   1.000 31.054  0 163 HIS   A NE2 1 ? 
ATOM   1263 N N   . HIS   A 1 164 ? -16.574 -28.926 6.366   1.000 35.880  0 164 HIS   A N   1 ? 
ATOM   1264 C CA  . HIS   A 1 164 ? -16.949 -28.997 4.959   1.000 32.786  0 164 HIS   A CA  1 ? 
ATOM   1265 C C   . HIS   A 1 164 ? -16.372 -27.856 4.131   1.000 34.524  0 164 HIS   A C   1 ? 
ATOM   1266 O O   . HIS   A 1 164 ? -15.841 -28.108 3.054   1.000 37.254  0 164 HIS   A O   1 ? 
ATOM   1267 C CB  . HIS   A 1 164 ? -18.465 -28.961 4.762   1.000 30.112  0 164 HIS   A CB  1 ? 
ATOM   1268 C CG  . HIS   A 1 164 ? -19.172 -30.189 5.212   1.000 27.565  0 164 HIS   A CG  1 ? 
ATOM   1269 N ND1 . HIS   A 1 164 ? -19.934 -30.964 4.373   1.000 28.949  0 164 HIS   A ND1 1 ? 
ATOM   1270 C CD2 . HIS   A 1 164 ? -19.271 -30.743 6.404   1.000 27.119  0 164 HIS   A CD2 1 ? 
ATOM   1271 C CE1 . HIS   A 1 164 ? -20.459 -31.962 5.056   1.000 28.514  0 164 HIS   A CE1 1 ? 
ATOM   1272 N NE2 . HIS   A 1 164 ? -20.071 -31.840 6.297   1.000 27.420  0 164 HIS   A NE2 1 ? 
ATOM   1273 N N   . MET   A 1 165 ? -16.532 -26.608 4.586   1.000 37.493  0 165 MET   A N   1 ? 
ATOM   1274 C CA  . MET   A 1 165 ? -16.303 -25.469 3.709   1.000 39.503  0 165 MET   A CA  1 ? 
ATOM   1275 C C   . MET   A 1 165 ? -15.379 -24.438 4.339   1.000 38.836  0 165 MET   A C   1 ? 
ATOM   1276 O O   . MET   A 1 165 ? -15.328 -24.302 5.556   1.000 39.738  0 165 MET   A O   1 ? 
ATOM   1277 C CB  . MET   A 1 165 ? -17.618 -24.759 3.388   1.000 40.459  0 165 MET   A CB  1 ? 
ATOM   1278 C CG  . MET   A 1 165 ? -18.688 -25.694 2.908   1.000 42.546  0 165 MET   A CG  1 ? 
ATOM   1279 S SD  . MET   A 1 165 ? -19.939 -24.879 1.901   1.000 51.069  0 165 MET   A SD  1 ? 
ATOM   1280 C CE  . MET   A 1 165 ? -19.819 -23.180 2.464   1.000 53.799  0 165 MET   A CE  1 ? 
ATOM   1281 N N   . GLU   A 1 166 ? -14.697 -23.686 3.469   1.000 39.231  0 166 GLU   A N   1 ? 
ATOM   1282 C CA  . GLU   A 1 166 ? -14.100 -22.412 3.832   1.000 40.952  0 166 GLU   A CA  1 ? 
ATOM   1283 C C   . GLU   A 1 166 ? -14.912 -21.307 3.164   1.000 41.837  0 166 GLU   A C   1 ? 
ATOM   1284 O O   . GLU   A 1 166 ? -15.461 -21.512 2.093   1.000 42.317  0 166 GLU   A O   1 ? 
ATOM   1285 C CB  . GLU   A 1 166 ? -12.638 -22.382 3.395   1.000 42.640  0 166 GLU   A CB  1 ? 
ATOM   1286 C CG  . GLU   A 1 166 ? -11.854 -21.202 3.933   1.000 45.401  0 166 GLU   A CG  1 ? 
ATOM   1287 C CD  . GLU   A 1 166 ? -10.346 -21.356 3.793   1.000 48.165  0 166 GLU   A CD  1 ? 
ATOM   1288 O OE1 . GLU   A 1 166 ? -9.822  -21.106 2.679   1.000 55.030  0 166 GLU   A OE1 1 ? 
ATOM   1289 O OE2 . GLU   A 1 166 ? -9.693  -21.748 4.792   1.000 43.066  0 166 GLU   A OE2 1 ? 
ATOM   1290 N N   . LEU   A 1 167 ? -15.012 -20.154 3.827   1.000 44.386  0 167 LEU   A N   1 ? 
ATOM   1291 C CA  . LEU   A 1 167 ? -15.790 -19.025 3.344   1.000 48.505  0 167 LEU   A CA  1 ? 
ATOM   1292 C C   . LEU   A 1 167 ? -14.834 -17.896 2.979   1.000 53.167  0 167 LEU   A C   1 ? 
ATOM   1293 O O   . LEU   A 1 167 ? -13.674 -17.937 3.392   1.000 54.011  0 167 LEU   A O   1 ? 
ATOM   1294 C CB  . LEU   A 1 167 ? -16.731 -18.580 4.463   1.000 53.934  0 167 LEU   A CB  1 ? 
ATOM   1295 C CG  . LEU   A 1 167 ? -17.857 -19.548 4.803   1.000 55.884  0 167 LEU   A CG  1 ? 
ATOM   1296 C CD1 . LEU   A 1 167 ? -18.430 -19.249 6.181   1.000 56.641  0 167 LEU   A CD1 1 ? 
ATOM   1297 C CD2 . LEU   A 1 167 ? -18.946 -19.475 3.745   1.000 58.333  0 167 LEU   A CD2 1 ? 
ATOM   1298 N N   . PRO   A 1 168 ? -15.289 -16.832 2.264   1.000 60.490  0 168 PRO   A N   1 ? 
ATOM   1299 C CA  . PRO   A 1 168 ? -14.364 -15.874 1.652   1.000 60.432  0 168 PRO   A CA  1 ? 
ATOM   1300 C C   . PRO   A 1 168 ? -13.461 -15.227 2.702   1.000 59.731  0 168 PRO   A C   1 ? 
ATOM   1301 O O   . PRO   A 1 168 ? -12.370 -14.760 2.391   1.000 64.710  0 168 PRO   A O   1 ? 
ATOM   1302 C CB  . PRO   A 1 168 ? -15.282 -14.852 0.958   1.000 60.565  0 168 PRO   A CB  1 ? 
ATOM   1303 C CG  . PRO   A 1 168 ? -16.609 -15.580 0.803   1.000 60.716  0 168 PRO   A CG  1 ? 
ATOM   1304 C CD  . PRO   A 1 168 ? -16.697 -16.465 2.027   1.000 60.782  0 168 PRO   A CD  1 ? 
ATOM   1305 N N   . THR   A 1 169 ? -13.902 -15.293 3.960   1.000 55.651  0 169 THR   A N   1 ? 
ATOM   1306 C CA  . THR   A 1 169 ? -13.331 -14.514 5.039   1.000 53.276  0 169 THR   A CA  1 ? 
ATOM   1307 C C   . THR   A 1 169 ? -12.175 -15.247 5.718   1.000 53.349  0 169 THR   A C   1 ? 
ATOM   1308 O O   . THR   A 1 169 ? -11.576 -14.712 6.640   1.000 51.542  0 169 THR   A O   1 ? 
ATOM   1309 C CB  . THR   A 1 169 ? -14.451 -14.231 6.040   1.000 55.350  0 169 THR   A CB  1 ? 
ATOM   1310 O OG1 . THR   A 1 169 ? -15.623 -14.797 5.440   1.000 54.870  0 169 THR   A OG1 1 ? 
ATOM   1311 C CG2 . THR   A 1 169 ? -14.593 -12.757 6.356   1.000 54.069  0 169 THR   A CG2 1 ? 
ATOM   1312 N N   . GLY   A 1 170 ? -11.862 -16.472 5.281   1.000 58.819  0 170 GLY   A N   1 ? 
ATOM   1313 C CA  . GLY   A 1 170 ? -10.904 -17.314 5.984   1.000 53.837  0 170 GLY   A CA  1 ? 
ATOM   1314 C C   . GLY   A 1 170 ? -11.523 -17.961 7.222   1.000 49.772  0 170 GLY   A C   1 ? 
ATOM   1315 O O   . GLY   A 1 170 ? -10.837 -18.162 8.221   1.000 51.451  0 170 GLY   A O   1 ? 
ATOM   1316 N N   . VAL   A 1 171 ? -12.824 -18.277 7.127   1.000 44.831  0 171 VAL   A N   1 ? 
ATOM   1317 C CA  . VAL   A 1 171 ? -13.593 -18.920 8.183   1.000 43.381  0 171 VAL   A CA  1 ? 
ATOM   1318 C C   . VAL   A 1 171 ? -14.303 -20.127 7.583   1.000 40.162  0 171 VAL   A C   1 ? 
ATOM   1319 O O   . VAL   A 1 171 ? -14.355 -20.274 6.368   1.000 41.113  0 171 VAL   A O   1 ? 
ATOM   1320 C CB  . VAL   A 1 171 ? -14.616 -17.962 8.826   1.000 47.396  0 171 VAL   A CB  1 ? 
ATOM   1321 C CG1 . VAL   A 1 171 ? -13.952 -16.961 9.761   1.000 49.101  0 171 VAL   A CG1 1 ? 
ATOM   1322 C CG2 . VAL   A 1 171 ? -15.462 -17.246 7.785   1.000 49.043  0 171 VAL   A CG2 1 ? 
ATOM   1323 N N   . HIS   A 1 172 ? -14.899 -20.956 8.443   1.000 38.788  0 172 HIS   A N   1 ? 
ATOM   1324 C CA  . HIS   A 1 172 ? -15.262 -22.313 8.072   1.000 39.350  0 172 HIS   A CA  1 ? 
ATOM   1325 C C   . HIS   A 1 172 ? -16.712 -22.589 8.450   1.000 39.014  0 172 HIS   A C   1 ? 
ATOM   1326 O O   . HIS   A 1 172 ? -17.195 -22.072 9.448   1.000 43.985  0 172 HIS   A O   1 ? 
ATOM   1327 C CB  . HIS   A 1 172 ? -14.275 -23.279 8.736   1.000 38.337  0 172 HIS   A CB  1 ? 
ATOM   1328 C CG  . HIS   A 1 172 ? -12.863 -22.873 8.475   1.000 37.154  0 172 HIS   A CG  1 ? 
ATOM   1329 N ND1 . HIS   A 1 172 ? -12.144 -22.089 9.348   1.000 37.658  0 172 HIS   A ND1 1 ? 
ATOM   1330 C CD2 . HIS   A 1 172 ? -12.074 -23.061 7.412   1.000 36.714  0 172 HIS   A CD2 1 ? 
ATOM   1331 C CE1 . HIS   A 1 172 ? -10.945 -21.858 8.829   1.000 40.095  0 172 HIS   A CE1 1 ? 
ATOM   1332 N NE2 . HIS   A 1 172 ? -10.879 -22.443 7.655   1.000 37.161  0 172 HIS   A NE2 1 ? 
ATOM   1333 N N   . ALA   A 1 173 ? -17.393 -23.410 7.644   1.000 39.608  0 173 ALA   A N   1 ? 
ATOM   1334 C CA  . ALA   A 1 173 ? -18.725 -23.904 7.968   1.000 39.298  0 173 ALA   A CA  1 ? 
ATOM   1335 C C   . ALA   A 1 173 ? -18.755 -25.425 7.830   1.000 40.307  0 173 ALA   A C   1 ? 
ATOM   1336 O O   . ALA   A 1 173 ? -17.963 -26.022 7.091   1.000 39.293  0 173 ALA   A O   1 ? 
ATOM   1337 C CB  . ALA   A 1 173 ? -19.763 -23.254 7.083   1.000 38.989  0 173 ALA   A CB  1 ? 
ATOM   1338 N N   . GLY   A 1 174 ? -19.693 -26.039 8.552   1.000 39.036  0 174 GLY   A N   1 ? 
ATOM   1339 C CA  . GLY   A 1 174 ? -19.811 -27.482 8.577   1.000 36.999  0 174 GLY   A CA  1 ? 
ATOM   1340 C C   . GLY   A 1 174 ? -21.092 -27.941 9.263   1.000 37.579  0 174 GLY   A C   1 ? 
ATOM   1341 O O   . GLY   A 1 174 ? -22.014 -27.156 9.478   1.000 37.828  0 174 GLY   A O   1 ? 
ATOM   1342 N N   . THR   A 1 175 ? -21.120 -29.236 9.587   1.000 38.549  0 175 THR   A N   1 ? 
ATOM   1343 C CA  . THR   A 1 175 ? -22.350 -29.948 9.885   1.000 39.882  0 175 THR   A CA  1 ? 
ATOM   1344 C C   . THR   A 1 175 ? -22.280 -30.519 11.287  1.000 36.576  0 175 THR   A C   1 ? 
ATOM   1345 O O   . THR   A 1 175 ? -21.183 -30.704 11.813  1.000 37.046  0 175 THR   A O   1 ? 
ATOM   1346 C CB  . THR   A 1 175 ? -22.566 -31.125 8.923   1.000 40.686  0 175 THR   A CB  1 ? 
ATOM   1347 O OG1 . THR   A 1 175 ? -21.294 -31.720 8.652   1.000 39.869  0 175 THR   A OG1 1 ? 
ATOM   1348 C CG2 . THR   A 1 175 ? -23.208 -30.712 7.623   1.000 40.751  0 175 THR   A CG2 1 ? 
ATOM   1349 N N   . ASP   A 1 176 ? -23.445 -30.861 11.842  1.000 35.623  0 176 ASP   A N   1 ? 
ATOM   1350 C CA  . ASP   A 1 176 ? -23.463 -31.798 12.956  1.000 37.116  0 176 ASP   A CA  1 ? 
ATOM   1351 C C   . ASP   A 1 176 ? -23.177 -33.171 12.361  1.000 37.461  0 176 ASP   A C   1 ? 
ATOM   1352 O O   . ASP   A 1 176 ? -22.878 -33.279 11.173  1.000 37.672  0 176 ASP   A O   1 ? 
ATOM   1353 C CB  . ASP   A 1 176 ? -24.759 -31.704 13.766  1.000 38.140  0 176 ASP   A CB  1 ? 
ATOM   1354 C CG  . ASP   A 1 176 ? -26.011 -32.007 12.968  1.000 41.420  0 176 ASP   A CG  1 ? 
ATOM   1355 O OD1 . ASP   A 1 176 ? -25.877 -32.612 11.876  1.000 39.166  0 176 ASP   A OD1 1 ? 
ATOM   1356 O OD2 . ASP   A 1 176 ? -27.113 -31.605 13.437  1.000 42.365  0 176 ASP   A OD2 1 ? 
ATOM   1357 N N   . LEU   A 1 177 ? -23.253 -34.220 13.178  1.000 39.819  0 177 LEU   A N   1 ? 
ATOM   1358 C CA  . LEU   A 1 177 ? -22.943 -35.551 12.684  1.000 42.648  0 177 LEU   A CA  1 ? 
ATOM   1359 C C   . LEU   A 1 177 ? -24.177 -36.239 12.106  1.000 47.150  0 177 LEU   A C   1 ? 
ATOM   1360 O O   . LEU   A 1 177 ? -24.062 -37.369 11.644  1.000 51.071  0 177 LEU   A O   1 ? 
ATOM   1361 C CB  . LEU   A 1 177 ? -22.312 -36.367 13.810  1.000 41.215  0 177 LEU   A CB  1 ? 
ATOM   1362 C CG  . LEU   A 1 177 ? -20.790 -36.428 13.769  1.000 39.354  0 177 LEU   A CG  1 ? 
ATOM   1363 C CD1 . LEU   A 1 177 ? -20.321 -37.254 12.591  1.000 39.599  0 177 LEU   A CD1 1 ? 
ATOM   1364 C CD2 . LEU   A 1 177 ? -20.195 -35.031 13.708  1.000 41.798  0 177 LEU   A CD2 1 ? 
ATOM   1365 N N   . GLU   A 1 178 ? -25.331 -35.553 12.112  1.000 50.092  0 178 GLU   A N   1 ? 
ATOM   1366 C CA  . GLU   A 1 178 ? -26.484 -35.977 11.331  1.000 52.816  0 178 GLU   A CA  1 ? 
ATOM   1367 C C   . GLU   A 1 178 ? -26.463 -35.274 9.976   1.000 50.488  0 178 GLU   A C   1 ? 
ATOM   1368 O O   . GLU   A 1 178 ? -27.312 -35.531 9.126   1.000 48.494  0 178 GLU   A O   1 ? 
ATOM   1369 C CB  . GLU   A 1 178 ? -27.784 -35.646 12.059  1.000 59.852  0 178 GLU   A CB  1 ? 
ATOM   1370 C CG  . GLU   A 1 178 ? -27.792 -36.056 13.523  1.000 66.777  0 178 GLU   A CG  1 ? 
ATOM   1371 C CD  . GLU   A 1 178 ? -28.867 -35.362 14.343  1.000 70.061  0 178 GLU   A CD  1 ? 
ATOM   1372 O OE1 . GLU   A 1 178 ? -28.544 -34.344 15.017  1.000 72.069  0 178 GLU   A OE1 1 ? 
ATOM   1373 O OE2 . GLU   A 1 178 ? -30.021 -35.837 14.301  1.000 66.014  0 178 GLU   A OE2 1 ? 
ATOM   1374 N N   . GLY   A 1 179 ? -25.522 -34.338 9.816   1.000 49.106  0 179 GLY   A N   1 ? 
ATOM   1375 C CA  . GLY   A 1 179 ? -25.181 -33.788 8.517   1.000 49.938  0 179 GLY   A CA  1 ? 
ATOM   1376 C C   . GLY   A 1 179 ? -25.936 -32.506 8.180   1.000 49.182  0 179 GLY   A C   1 ? 
ATOM   1377 O O   . GLY   A 1 179 ? -25.907 -32.070 7.038   1.000 47.589  0 179 GLY   A O   1 ? 
ATOM   1378 N N   . ASN   A 1 180 ? -26.608 -31.904 9.165   1.000 48.573  0 180 ASN   A N   1 ? 
ATOM   1379 C CA  . ASN   A 1 180 ? -27.287 -30.641 8.944   1.000 42.721  0 180 ASN   A CA  1 ? 
ATOM   1380 C C   . ASN   A 1 180 ? -26.285 -29.537 9.235   1.000 44.323  0 180 ASN   A C   1 ? 
ATOM   1381 O O   . ASN   A 1 180 ? -25.535 -29.607 10.204  1.000 43.237  0 180 ASN   A O   1 ? 
ATOM   1382 C CB  . ASN   A 1 180 ? -28.554 -30.529 9.783   1.000 41.793  0 180 ASN   A CB  1 ? 
ATOM   1383 C CG  . ASN   A 1 180 ? -29.389 -31.786 9.690   1.000 42.725  0 180 ASN   A CG  1 ? 
ATOM   1384 O OD1 . ASN   A 1 180 ? -29.088 -32.778 10.349  1.000 44.687  0 180 ASN   A OD1 1 ? 
ATOM   1385 N ND2 . ASN   A 1 180 ? -30.433 -31.758 8.878   1.000 42.010  0 180 ASN   A ND2 1 ? 
ATOM   1386 N N   . PHE   A 1 181 ? -26.235 -28.562 8.332   1.000 46.174  0 181 PHE   A N   1 ? 
ATOM   1387 C CA  . PHE   A 1 181 ? -25.326 -27.444 8.471   1.000 47.135  0 181 PHE   A CA  1 ? 
ATOM   1388 C C   . PHE   A 1 181 ? -25.737 -26.588 9.658   1.000 48.578  0 181 PHE   A C   1 ? 
ATOM   1389 O O   . PHE   A 1 181 ? -26.917 -26.351 9.897   1.000 50.721  0 181 PHE   A O   1 ? 
ATOM   1390 C CB  . PHE   A 1 181 ? -25.323 -26.589 7.200   1.000 51.449  0 181 PHE   A CB  1 ? 
ATOM   1391 C CG  . PHE   A 1 181 ? -24.241 -26.965 6.223   1.000 54.361  0 181 PHE   A CG  1 ? 
ATOM   1392 C CD1 . PHE   A 1 181 ? -22.966 -26.432 6.348   1.000 55.125  0 181 PHE   A CD1 1 ? 
ATOM   1393 C CD2 . PHE   A 1 181 ? -24.475 -27.894 5.220   1.000 56.205  0 181 PHE   A CD2 1 ? 
ATOM   1394 C CE1 . PHE   A 1 181 ? -21.956 -26.796 5.472   1.000 53.916  0 181 PHE   A CE1 1 ? 
ATOM   1395 C CE2 . PHE   A 1 181 ? -23.460 -28.265 4.350   1.000 56.363  0 181 PHE   A CE2 1 ? 
ATOM   1396 C CZ  . PHE   A 1 181 ? -22.202 -27.721 4.482   1.000 54.435  0 181 PHE   A CZ  1 ? 
ATOM   1397 N N   . TYR   A 1 182 ? -24.736 -26.112 10.388  1.000 48.722  0 182 TYR   A N   1 ? 
ATOM   1398 C CA  . TYR   A 1 182 ? -24.915 -24.952 11.237  1.000 47.726  0 182 TYR   A CA  1 ? 
ATOM   1399 C C   . TYR   A 1 182 ? -24.994 -23.706 10.361  1.000 47.994  0 182 TYR   A C   1 ? 
ATOM   1400 O O   . TYR   A 1 182 ? -24.142 -23.479 9.505   1.000 47.981  0 182 TYR   A O   1 ? 
ATOM   1401 C CB  . TYR   A 1 182 ? -23.740 -24.882 12.210  1.000 47.267  0 182 TYR   A CB  1 ? 
ATOM   1402 C CG  . TYR   A 1 182 ? -23.731 -26.006 13.233  1.000 45.871  0 182 TYR   A CG  1 ? 
ATOM   1403 C CD1 . TYR   A 1 182 ? -24.605 -26.009 14.317  1.000 45.407  0 182 TYR   A CD1 1 ? 
ATOM   1404 C CD2 . TYR   A 1 182 ? -22.839 -27.055 13.116  1.000 42.874  0 182 TYR   A CD2 1 ? 
ATOM   1405 C CE1 . TYR   A 1 182 ? -24.578 -27.020 15.262  1.000 44.763  0 182 TYR   A CE1 1 ? 
ATOM   1406 C CE2 . TYR   A 1 182 ? -22.807 -28.073 14.047  1.000 43.842  0 182 TYR   A CE2 1 ? 
ATOM   1407 C CZ  . TYR   A 1 182 ? -23.680 -28.062 15.119  1.000 46.386  0 182 TYR   A CZ  1 ? 
ATOM   1408 O OH  . TYR   A 1 182 ? -23.630 -29.089 16.020  1.000 46.971  0 182 TYR   A OH  1 ? 
ATOM   1409 N N   . GLY   A 1 183 ? -26.007 -22.881 10.611  1.000 50.056  0 183 GLY   A N   1 ? 
ATOM   1410 C CA  . GLY   A 1 183 ? -26.197 -21.672 9.837   1.000 51.138  0 183 GLY   A CA  1 ? 
ATOM   1411 C C   . GLY   A 1 183 ? -26.936 -21.986 8.546   1.000 55.474  0 183 GLY   A C   1 ? 
ATOM   1412 O O   . GLY   A 1 183 ? -27.510 -23.062 8.408   1.000 59.027  0 183 GLY   A O   1 ? 
ATOM   1413 N N   . PRO   A 1 184 ? -26.934 -21.065 7.561   1.000 55.757  0 184 PRO   A N   1 ? 
ATOM   1414 C CA  . PRO   A 1 184 ? -27.746 -21.215 6.360   1.000 56.114  0 184 PRO   A CA  1 ? 
ATOM   1415 C C   . PRO   A 1 184 ? -26.966 -21.747 5.166   1.000 53.932  0 184 PRO   A C   1 ? 
ATOM   1416 O O   . PRO   A 1 184 ? -27.430 -21.627 4.036   1.000 58.553  0 184 PRO   A O   1 ? 
ATOM   1417 C CB  . PRO   A 1 184 ? -28.111 -19.747 6.136   1.000 55.857  0 184 PRO   A CB  1 ? 
ATOM   1418 C CG  . PRO   A 1 184 ? -26.788 -19.050 6.390   1.000 55.926  0 184 PRO   A CG  1 ? 
ATOM   1419 C CD  . PRO   A 1 184 ? -26.166 -19.811 7.545   1.000 54.001  0 184 PRO   A CD  1 ? 
ATOM   1420 N N   . PHE   A 1 185 ? -25.789 -22.324 5.432   1.000 48.301  0 185 PHE   A N   1 ? 
ATOM   1421 C CA  . PHE   A 1 185 ? -24.833 -22.637 4.384   1.000 47.846  0 185 PHE   A CA  1 ? 
ATOM   1422 C C   . PHE   A 1 185 ? -25.221 -23.915 3.648   1.000 47.901  0 185 PHE   A C   1 ? 
ATOM   1423 O O   . PHE   A 1 185 ? -25.902 -24.781 4.207   1.000 47.889  0 185 PHE   A O   1 ? 
ATOM   1424 C CB  . PHE   A 1 185 ? -23.433 -22.807 4.969   1.000 50.697  0 185 PHE   A CB  1 ? 
ATOM   1425 C CG  . PHE   A 1 185 ? -22.930 -21.589 5.694   1.000 50.389  0 185 PHE   A CG  1 ? 
ATOM   1426 C CD1 . PHE   A 1 185 ? -22.619 -20.434 4.995   1.000 49.111  0 185 PHE   A CD1 1 ? 
ATOM   1427 C CD2 . PHE   A 1 185 ? -22.800 -21.593 7.071   1.000 50.796  0 185 PHE   A CD2 1 ? 
ATOM   1428 C CE1 . PHE   A 1 185 ? -22.163 -19.308 5.658   1.000 53.501  0 185 PHE   A CE1 1 ? 
ATOM   1429 C CE2 . PHE   A 1 185 ? -22.348 -20.464 7.736   1.000 54.836  0 185 PHE   A CE2 1 ? 
ATOM   1430 C CZ  . PHE   A 1 185 ? -22.029 -19.325 7.028   1.000 56.201  0 185 PHE   A CZ  1 ? 
ATOM   1431 N N   . VAL   A 1 186 ? -24.749 -24.004 2.391   1.000 47.166  0 186 VAL   A N   1 ? 
ATOM   1432 C CA  . VAL   A 1 186 ? -24.995 -25.144 1.516   1.000 44.344  0 186 VAL   A CA  1 ? 
ATOM   1433 C C   . VAL   A 1 186 ? -23.649 -25.654 1.017   1.000 41.878  0 186 VAL   A C   1 ? 
ATOM   1434 O O   . VAL   A 1 186 ? -22.739 -24.848 0.840   1.000 41.666  0 186 VAL   A O   1 ? 
ATOM   1435 C CB  . VAL   A 1 186 ? -25.913 -24.778 0.332   1.000 43.456  0 186 VAL   A CB  1 ? 
ATOM   1436 C CG1 . VAL   A 1 186 ? -27.321 -24.439 0.792   1.000 43.816  0 186 VAL   A CG1 1 ? 
ATOM   1437 C CG2 . VAL   A 1 186 ? -25.345 -23.649 -0.517  1.000 43.474  0 186 VAL   A CG2 1 ? 
ATOM   1438 N N   . ASP   A 1 187 ? -23.549 -26.975 0.785   1.000 41.021  0 187 ASP   A N   1 ? 
ATOM   1439 C CA  . ASP   A 1 187 ? -22.334 -27.591 0.264   1.000 41.985  0 187 ASP   A CA  1 ? 
ATOM   1440 C C   . ASP   A 1 187 ? -22.318 -27.437 -1.256  1.000 43.590  0 187 ASP   A C   1 ? 
ATOM   1441 O O   . ASP   A 1 187 ? -22.621 -28.377 -1.982  1.000 43.766  0 187 ASP   A O   1 ? 
ATOM   1442 C CB  . ASP   A 1 187 ? -22.139 -29.048 0.735   1.000 41.638  0 187 ASP   A CB  1 ? 
ATOM   1443 C CG  . ASP   A 1 187 ? -23.302 -30.021 0.563   1.000 39.297  0 187 ASP   A CG  1 ? 
ATOM   1444 O OD1 . ASP   A 1 187 ? -24.425 -29.565 0.305   1.000 38.606  0 187 ASP   A OD1 1 ? 
ATOM   1445 O OD2 . ASP   A 1 187 ? -23.070 -31.248 0.681   1.000 36.109  0 187 ASP   A OD2 1 ? 
ATOM   1446 N N   . ARG   A 1 188 ? -21.941 -26.234 -1.711  1.000 45.710  0 188 ARG   A N   1 ? 
ATOM   1447 C CA  . ARG   A 1 188 ? -21.867 -25.876 -3.119  1.000 48.924  0 188 ARG   A CA  1 ? 
ATOM   1448 C C   . ARG   A 1 188 ? -20.905 -24.698 -3.267  1.000 51.584  0 188 ARG   A C   1 ? 
ATOM   1449 O O   . ARG   A 1 188 ? -20.781 -23.882 -2.352  1.000 52.829  0 188 ARG   A O   1 ? 
ATOM   1450 C CB  . ARG   A 1 188 ? -23.267 -25.537 -3.648  1.000 53.985  0 188 ARG   A CB  1 ? 
ATOM   1451 C CG  . ARG   A 1 188 ? -23.277 -24.810 -4.987  1.000 58.535  0 188 ARG   A CG  1 ? 
ATOM   1452 C CD  . ARG   A 1 188 ? -24.661 -24.719 -5.596  1.000 63.881  0 188 ARG   A CD  1 ? 
ATOM   1453 N NE  . ARG   A 1 188 ? -24.643 -23.921 -6.820  1.000 71.012  0 188 ARG   A NE  1 ? 
ATOM   1454 C CZ  . ARG   A 1 188 ? -25.554 -23.014 -7.176  1.000 69.848  0 188 ARG   A CZ  1 ? 
ATOM   1455 N NH1 . ARG   A 1 188 ? -26.658 -22.838 -6.471  1.000 72.009  0 188 ARG   A NH1 1 ? 
ATOM   1456 N NH2 . ARG   A 1 188 ? -25.373 -22.302 -8.275  1.000 68.737  0 188 ARG   A NH2 1 ? 
ATOM   1457 N N   . GLN   A 1 189 ? -20.229 -24.596 -4.421  1.000 54.729  0 189 GLN   A N   1 ? 
ATOM   1458 C CA  . GLN   A 1 189 ? -19.322 -23.477 -4.651  1.000 54.685  0 189 GLN   A CA  1 ? 
ATOM   1459 C C   . GLN   A 1 189 ? -20.106 -22.308 -5.237  1.000 55.311  0 189 GLN   A C   1 ? 
ATOM   1460 O O   . GLN   A 1 189 ? -19.998 -22.035 -6.428  1.000 58.400  0 189 GLN   A O   1 ? 
ATOM   1461 C CB  . GLN   A 1 189 ? -18.159 -23.854 -5.568  1.000 50.318  0 189 GLN   A CB  1 ? 
ATOM   1462 C CG  . GLN   A 1 189 ? -17.243 -22.675 -5.860  1.000 48.141  0 189 GLN   A CG  1 ? 
ATOM   1463 C CD  . GLN   A 1 189 ? -15.961 -23.068 -6.549  1.000 46.898  0 189 GLN   A CD  1 ? 
ATOM   1464 O OE1 . GLN   A 1 189 ? -15.687 -24.245 -6.781  1.000 41.805  0 189 GLN   A OE1 1 ? 
ATOM   1465 N NE2 . GLN   A 1 189 ? -15.163 -22.065 -6.885  1.000 46.656  0 189 GLN   A NE2 1 ? 
ATOM   1466 N N   . THR   A 1 190 ? -20.900 -21.647 -4.383  1.000 57.608  0 190 THR   A N   1 ? 
ATOM   1467 C CA  . THR   A 1 190 ? -21.626 -20.436 -4.741  1.000 56.591  0 190 THR   A CA  1 ? 
ATOM   1468 C C   . THR   A 1 190 ? -21.167 -19.333 -3.793  1.000 54.877  0 190 THR   A C   1 ? 
ATOM   1469 O O   . THR   A 1 190 ? -20.411 -19.596 -2.864  1.000 52.505  0 190 THR   A O   1 ? 
ATOM   1470 C CB  . THR   A 1 190 ? -23.147 -20.673 -4.744  1.000 54.666  0 190 THR   A CB  1 ? 
ATOM   1471 O OG1 . THR   A 1 190 ? -23.807 -19.438 -5.014  1.000 56.233  0 190 THR   A OG1 1 ? 
ATOM   1472 C CG2 . THR   A 1 190 ? -23.688 -21.222 -3.444  1.000 52.188  0 190 THR   A CG2 1 ? 
ATOM   1473 N N   . ALA   A 1 191 ? -21.610 -18.100 -4.047  1.000 54.064  0 191 ALA   A N   1 ? 
ATOM   1474 C CA  . ALA   A 1 191 ? -21.269 -16.985 -3.183  1.000 54.250  0 191 ALA   A CA  1 ? 
ATOM   1475 C C   . ALA   A 1 191 ? -22.086 -17.093 -1.901  1.000 56.816  0 191 ALA   A C   1 ? 
ATOM   1476 O O   . ALA   A 1 191 ? -23.303 -17.239 -1.949  1.000 58.177  0 191 ALA   A O   1 ? 
ATOM   1477 C CB  . ALA   A 1 191 ? -21.514 -15.674 -3.887  1.000 55.731  0 191 ALA   A CB  1 ? 
ATOM   1478 N N   . GLN   A 1 192 ? -21.394 -17.044 -0.759  1.000 62.192  0 192 GLN   A N   1 ? 
ATOM   1479 C CA  . GLN   A 1 192 ? -22.023 -17.165 0.545   1.000 66.569  0 192 GLN   A CA  1 ? 
ATOM   1480 C C   . GLN   A 1 192 ? -21.303 -16.235 1.523   1.000 69.347  0 192 GLN   A C   1 ? 
ATOM   1481 O O   . GLN   A 1 192 ? -20.075 -16.264 1.652   1.000 62.087  0 192 GLN   A O   1 ? 
ATOM   1482 C CB  . GLN   A 1 192 ? -22.010 -18.623 1.023   1.000 65.530  0 192 GLN   A CB  1 ? 
ATOM   1483 C CG  . GLN   A 1 192 ? -22.697 -19.601 0.074   1.000 62.843  0 192 GLN   A CG  1 ? 
ATOM   1484 C CD  . GLN   A 1 192 ? -22.946 -20.965 0.680   1.000 62.030  0 192 GLN   A CD  1 ? 
ATOM   1485 O OE1 . GLN   A 1 192 ? -23.713 -21.116 1.630   1.000 63.278  0 192 GLN   A OE1 1 ? 
ATOM   1486 N NE2 . GLN   A 1 192 ? -22.316 -21.987 0.125   1.000 60.367  0 192 GLN   A NE2 1 ? 
ATOM   1487 N N   . ALA   A 1 193 ? -22.106 -15.393 2.185   1.000 71.715  0 193 ALA   A N   1 ? 
ATOM   1488 C CA  . ALA   A 1 193 ? -21.630 -14.438 3.166   1.000 69.074  0 193 ALA   A CA  1 ? 
ATOM   1489 C C   . ALA   A 1 193 ? -21.869 -15.010 4.555   1.000 67.170  0 193 ALA   A C   1 ? 
ATOM   1490 O O   . ALA   A 1 193 ? -22.834 -15.739 4.766   1.000 63.259  0 193 ALA   A O   1 ? 
ATOM   1491 C CB  . ALA   A 1 193 ? -22.355 -13.125 2.992   1.000 72.190  0 193 ALA   A CB  1 ? 
ATOM   1492 N N   . ALA   A 1 194 ? -20.989 -14.649 5.492   1.000 70.409  0 194 ALA   A N   1 ? 
ATOM   1493 C CA  . ALA   A 1 194 ? -21.103 -15.086 6.872   1.000 74.171  0 194 ALA   A CA  1 ? 
ATOM   1494 C C   . ALA   A 1 194 ? -22.375 -14.525 7.518   1.000 76.941  0 194 ALA   A C   1 ? 
ATOM   1495 O O   . ALA   A 1 194 ? -23.170 -15.281 8.080   1.000 73.849  0 194 ALA   A O   1 ? 
ATOM   1496 C CB  . ALA   A 1 194 ? -19.860 -14.674 7.629   1.000 69.777  0 194 ALA   A CB  1 ? 
ATOM   1497 N N   . GLY   A 1 195 ? -22.565 -13.200 7.407   1.000 73.916  0 195 GLY   A N   1 ? 
ATOM   1498 C CA  . GLY   A 1 195 ? -23.466 -12.456 8.277   1.000 67.576  0 195 GLY   A CA  1 ? 
ATOM   1499 C C   . GLY   A 1 195 ? -22.684 -11.757 9.390   1.000 63.027  0 195 GLY   A C   1 ? 
ATOM   1500 O O   . GLY   A 1 195 ? -21.478 -11.963 9.537   1.000 56.909  0 195 GLY   A O   1 ? 
ATOM   1501 N N   . THR   A 1 196 ? -23.375 -10.937 10.186  1.000 62.165  0 196 THR   A N   1 ? 
ATOM   1502 C CA  . THR   A 1 196 ? -22.716 -10.135 11.206  1.000 61.271  0 196 THR   A CA  1 ? 
ATOM   1503 C C   . THR   A 1 196 ? -22.223 -11.028 12.343  1.000 59.125  0 196 THR   A C   1 ? 
ATOM   1504 O O   . THR   A 1 196 ? -23.024 -11.693 13.000  1.000 58.899  0 196 THR   A O   1 ? 
ATOM   1505 C CB  . THR   A 1 196 ? -23.653 -9.056  11.762  1.000 64.018  0 196 THR   A CB  1 ? 
ATOM   1506 O OG1 . THR   A 1 196 ? -24.190 -8.307  10.673  1.000 67.127  0 196 THR   A OG1 1 ? 
ATOM   1507 C CG2 . THR   A 1 196 ? -22.958 -8.105  12.712  1.000 66.866  0 196 THR   A CG2 1 ? 
ATOM   1508 N N   . ASP   A 1 197 ? -20.904 -10.997 12.590  1.000 57.045  0 197 ASP   A N   1 ? 
ATOM   1509 C CA  . ASP   A 1 197 ? -20.293 -11.805 13.635  1.000 55.707  0 197 ASP   A CA  1 ? 
ATOM   1510 C C   . ASP   A 1 197 ? -20.289 -11.044 14.959  1.000 56.647  0 197 ASP   A C   1 ? 
ATOM   1511 O O   . ASP   A 1 197 ? -19.500 -10.122 15.164  1.000 53.202  0 197 ASP   A O   1 ? 
ATOM   1512 C CB  . ASP   A 1 197 ? -18.855 -12.205 13.305  1.000 57.435  0 197 ASP   A CB  1 ? 
ATOM   1513 C CG  . ASP   A 1 197 ? -18.322 -13.279 14.239  1.000 56.836  0 197 ASP   A CG  1 ? 
ATOM   1514 O OD1 . ASP   A 1 197 ? -19.167 -14.031 14.814  1.000 51.616  0 197 ASP   A OD1 1 ? 
ATOM   1515 O OD2 . ASP   A 1 197 ? -17.074 -13.343 14.404  1.000 54.724  0 197 ASP   A OD2 1 ? 
ATOM   1516 N N   . THR   A 1 198 ? -21.152 -11.482 15.876  1.000 52.597  0 198 THR   A N   1 ? 
ATOM   1517 C CA  . THR   A 1 198 ? -21.314 -10.809 17.146  1.000 49.052  0 198 THR   A CA  1 ? 
ATOM   1518 C C   . THR   A 1 198 ? -20.440 -11.497 18.191  1.000 48.333  0 198 THR   A C   1 ? 
ATOM   1519 O O   . THR   A 1 198 ? -19.926 -12.595 17.972  1.000 42.880  0 198 THR   A O   1 ? 
ATOM   1520 C CB  . THR   A 1 198 ? -22.799 -10.759 17.520  1.000 50.295  0 198 THR   A CB  1 ? 
ATOM   1521 O OG1 . THR   A 1 198 ? -23.208 -12.101 17.776  1.000 48.666  0 198 THR   A OG1 1 ? 
ATOM   1522 C CG2 . THR   A 1 198 ? -23.663 -10.143 16.436  1.000 51.719  0 198 THR   A CG2 1 ? 
ATOM   1523 N N   . THR   A 1 199 ? -20.292 -10.819 19.335  1.000 47.969  0 199 THR   A N   1 ? 
ATOM   1524 C CA  . THR   A 1 199 ? -19.499 -11.310 20.448  1.000 47.058  0 199 THR   A CA  1 ? 
ATOM   1525 C C   . THR   A 1 199 ? -20.390 -12.040 21.454  1.000 46.647  0 199 THR   A C   1 ? 
ATOM   1526 O O   . THR   A 1 199 ? -21.517 -11.619 21.709  1.000 44.696  0 199 THR   A O   1 ? 
ATOM   1527 C CB  . THR   A 1 199 ? -18.723 -10.149 21.066  1.000 45.235  0 199 THR   A CB  1 ? 
ATOM   1528 O OG1 . THR   A 1 199 ? -18.010 -9.561  19.973  1.000 44.370  0 199 THR   A OG1 1 ? 
ATOM   1529 C CG2 . THR   A 1 199 ? -17.805 -10.588 22.186  1.000 42.264  0 199 THR   A CG2 1 ? 
ATOM   1530 N N   . ILE   A 1 200 ? -19.863 -13.148 22.001  1.000 45.506  0 200 ILE   A N   1 ? 
ATOM   1531 C CA  . ILE   A 1 200 ? -20.595 -14.007 22.917  1.000 44.337  0 200 ILE   A CA  1 ? 
ATOM   1532 C C   . ILE   A 1 200 ? -20.383 -13.463 24.328  1.000 45.009  0 200 ILE   A C   1 ? 
ATOM   1533 O O   . ILE   A 1 200 ? -19.425 -13.814 25.024  1.000 38.533  0 200 ILE   A O   1 ? 
ATOM   1534 C CB  . ILE   A 1 200 ? -20.151 -15.477 22.796  1.000 47.489  0 200 ILE   A CB  1 ? 
ATOM   1535 C CG1 . ILE   A 1 200 ? -20.136 -15.966 21.344  1.000 47.839  0 200 ILE   A CG1 1 ? 
ATOM   1536 C CG2 . ILE   A 1 200 ? -21.023 -16.363 23.676  1.000 49.862  0 200 ILE   A CG2 1 ? 
ATOM   1537 C CD1 . ILE   A 1 200 ? -19.155 -17.089 21.086  1.000 47.237  0 200 ILE   A CD1 1 ? 
ATOM   1538 N N   . THR   A 1 201 ? -21.313 -12.590 24.720  1.000 44.131  0 201 THR   A N   1 ? 
ATOM   1539 C CA  . THR   A 1 201 ? -21.180 -11.757 25.896  1.000 42.447  0 201 THR   A CA  1 ? 
ATOM   1540 C C   . THR   A 1 201 ? -20.973 -12.624 27.131  1.000 41.374  0 201 THR   A C   1 ? 
ATOM   1541 O O   . THR   A 1 201 ? -20.054 -12.412 27.927  1.000 41.205  0 201 THR   A O   1 ? 
ATOM   1542 C CB  . THR   A 1 201 ? -22.441 -10.907 26.048  1.000 43.995  0 201 THR   A CB  1 ? 
ATOM   1543 O OG1 . THR   A 1 201 ? -22.753 -10.354 24.769  1.000 38.625  0 201 THR   A OG1 1 ? 
ATOM   1544 C CG2 . THR   A 1 201 ? -22.275 -9.828  27.093  1.000 47.780  0 201 THR   A CG2 1 ? 
ATOM   1545 N N   . VAL   A 1 202 ? -21.846 -13.617 27.268  1.000 39.868  0 202 VAL   A N   1 ? 
ATOM   1546 C CA  . VAL   A 1 202 ? -21.808 -14.484 28.428  1.000 42.701  0 202 VAL   A CA  1 ? 
ATOM   1547 C C   . VAL   A 1 202 ? -20.416 -15.112 28.560  1.000 41.637  0 202 VAL   A C   1 ? 
ATOM   1548 O O   . VAL   A 1 202 ? -19.859 -15.157 29.656  1.000 42.910  0 202 VAL   A O   1 ? 
ATOM   1549 C CB  . VAL   A 1 202 ? -22.956 -15.510 28.389  1.000 45.449  0 202 VAL   A CB  1 ? 
ATOM   1550 C CG1 . VAL   A 1 202 ? -22.976 -16.314 27.097  1.000 50.998  0 202 VAL   A CG1 1 ? 
ATOM   1551 C CG2 . VAL   A 1 202 ? -22.933 -16.430 29.600  1.000 47.806  0 202 VAL   A CG2 1 ? 
ATOM   1552 N N   . ASN   A 1 203 ? -19.827 -15.538 27.441  1.000 40.459  0 203 ASN   A N   1 ? 
ATOM   1553 C CA  . ASN   A 1 203 ? -18.507 -16.151 27.467  1.000 41.019  0 203 ASN   A CA  1 ? 
ATOM   1554 C C   . ASN   A 1 203 ? -17.441 -15.126 27.851  1.000 40.554  0 203 ASN   A C   1 ? 
ATOM   1555 O O   . ASN   A 1 203 ? -16.448 -15.465 28.490  1.000 38.009  0 203 ASN   A O   1 ? 
ATOM   1556 C CB  . ASN   A 1 203 ? -18.139 -16.792 26.129  1.000 39.521  0 203 ASN   A CB  1 ? 
ATOM   1557 C CG  . ASN   A 1 203 ? -18.948 -18.022 25.787  1.000 38.753  0 203 ASN   A CG  1 ? 
ATOM   1558 O OD1 . ASN   A 1 203 ? -18.771 -18.574 24.709  1.000 46.075  0 203 ASN   A OD1 1 ? 
ATOM   1559 N ND2 . ASN   A 1 203 ? -19.838 -18.462 26.657  1.000 37.136  0 203 ASN   A ND2 1 ? 
ATOM   1560 N N   . VAL   A 1 204 ? -17.629 -13.872 27.448  1.000 45.338  0 204 VAL   A N   1 ? 
ATOM   1561 C CA  . VAL   A 1 204 ? -16.661 -12.844 27.801  1.000 47.758  0 204 VAL   A CA  1 ? 
ATOM   1562 C C   . VAL   A 1 204 ? -16.632 -12.706 29.315  1.000 48.430  0 204 VAL   A C   1 ? 
ATOM   1563 O O   . VAL   A 1 204 ? -15.554 -12.641 29.909  1.000 47.794  0 204 VAL   A O   1 ? 
ATOM   1564 C CB  . VAL   A 1 204 ? -16.966 -11.485 27.150  1.000 42.885  0 204 VAL   A CB  1 ? 
ATOM   1565 C CG1 . VAL   A 1 204 ? -15.968 -10.445 27.617  1.000 42.223  0 204 VAL   A CG1 1 ? 
ATOM   1566 C CG2 . VAL   A 1 204 ? -16.969 -11.577 25.633  1.000 41.608  0 204 VAL   A CG2 1 ? 
ATOM   1567 N N   . LEU   A 1 205 ? -17.835 -12.672 29.902  1.000 47.614  0 205 LEU   A N   1 ? 
ATOM   1568 C CA  . LEU   A 1 205 ? -18.011 -12.440 31.327  1.000 46.890  0 205 LEU   A CA  1 ? 
ATOM   1569 C C   . LEU   A 1 205 ? -17.287 -13.510 32.135  1.000 46.240  0 205 LEU   A C   1 ? 
ATOM   1570 O O   . LEU   A 1 205 ? -16.661 -13.220 33.148  1.000 53.921  0 205 LEU   A O   1 ? 
ATOM   1571 C CB  . LEU   A 1 205 ? -19.509 -12.449 31.638  1.000 45.889  0 205 LEU   A CB  1 ? 
ATOM   1572 C CG  . LEU   A 1 205 ? -20.296 -11.276 31.055  1.000 46.239  0 205 LEU   A CG  1 ? 
ATOM   1573 C CD1 . LEU   A 1 205 ? -21.791 -11.447 31.275  1.000 45.023  0 205 LEU   A CD1 1 ? 
ATOM   1574 C CD2 . LEU   A 1 205 ? -19.827 -9.961  31.653  1.000 48.442  0 205 LEU   A CD2 1 ? 
ATOM   1575 N N   . ALA   A 1 206 ? -17.387 -14.756 31.689  1.000 44.492  0 206 ALA   A N   1 ? 
ATOM   1576 C CA  . ALA   A 1 206 ? -16.724 -15.847 32.378  1.000 46.207  0 206 ALA   A CA  1 ? 
ATOM   1577 C C   . ALA   A 1 206 ? -15.204 -15.665 32.308  1.000 41.956  0 206 ALA   A C   1 ? 
ATOM   1578 O O   . ALA   A 1 206 ? -14.480 -15.909 33.277  1.000 39.700  0 206 ALA   A O   1 ? 
ATOM   1579 C CB  . ALA   A 1 206 ? -17.175 -17.148 31.765  1.000 46.880  0 206 ALA   A CB  1 ? 
ATOM   1580 N N   . TRP   A 1 207 ? -14.732 -15.211 31.148  1.000 37.525  0 207 TRP   A N   1 ? 
ATOM   1581 C CA  . TRP   A 1 207 ? -13.317 -14.974 30.930  1.000 37.466  0 207 TRP   A CA  1 ? 
ATOM   1582 C C   . TRP   A 1 207 ? -12.811 -13.938 31.938  1.000 37.115  0 207 TRP   A C   1 ? 
ATOM   1583 O O   . TRP   A 1 207 ? -11.675 -13.990 32.411  1.000 32.035  0 207 TRP   A O   1 ? 
ATOM   1584 C CB  . TRP   A 1 207 ? -13.106 -14.555 29.466  1.000 37.891  0 207 TRP   A CB  1 ? 
ATOM   1585 C CG  . TRP   A 1 207 ? -11.691 -14.177 29.133  1.000 39.797  0 207 TRP   A CG  1 ? 
ATOM   1586 C CD1 . TRP   A 1 207 ? -10.605 -14.995 29.033  1.000 41.224  0 207 TRP   A CD1 1 ? 
ATOM   1587 C CD2 . TRP   A 1 207 ? -11.211 -12.846 28.874  1.000 38.760  0 207 TRP   A CD2 1 ? 
ATOM   1588 N NE1 . TRP   A 1 207 ? -9.486  -14.268 28.725  1.000 41.344  0 207 TRP   A NE1 1 ? 
ATOM   1589 C CE2 . TRP   A 1 207 ? -9.827  -12.949 28.622  1.000 39.097  0 207 TRP   A CE2 1 ? 
ATOM   1590 C CE3 . TRP   A 1 207 ? -11.817 -11.588 28.828  1.000 38.673  0 207 TRP   A CE3 1 ? 
ATOM   1591 C CZ2 . TRP   A 1 207 ? -9.045  -11.837 28.325  1.000 40.626  0 207 TRP   A CZ2 1 ? 
ATOM   1592 C CZ3 . TRP   A 1 207 ? -11.041 -10.489 28.536  1.000 37.619  0 207 TRP   A CZ3 1 ? 
ATOM   1593 C CH2 . TRP   A 1 207 ? -9.676  -10.612 28.282  1.000 38.621  0 207 TRP   A CH2 1 ? 
ATOM   1594 N N   . LEU   A 1 208 ? -13.695 -13.011 32.307  1.000 38.297  0 208 LEU   A N   1 ? 
ATOM   1595 C CA  . LEU   A 1 208 ? -13.372 -12.019 33.313  1.000 39.806  0 208 LEU   A CA  1 ? 
ATOM   1596 C C   . LEU   A 1 208 ? -13.256 -12.686 34.680  1.000 41.371  0 208 LEU   A C   1 ? 
ATOM   1597 O O   . LEU   A 1 208 ? -12.249 -12.540 35.376  1.000 42.362  0 208 LEU   A O   1 ? 
ATOM   1598 C CB  . LEU   A 1 208 ? -14.458 -10.946 33.280  1.000 40.932  0 208 LEU   A CB  1 ? 
ATOM   1599 C CG  . LEU   A 1 208 ? -14.527 -10.168 31.966  1.000 45.884  0 208 LEU   A CG  1 ? 
ATOM   1600 C CD1 . LEU   A 1 208 ? -15.702 -9.199  31.954  1.000 49.759  0 208 LEU   A CD1 1 ? 
ATOM   1601 C CD2 . LEU   A 1 208 ? -13.224 -9.420  31.700  1.000 43.938  0 208 LEU   A CD2 1 ? 
ATOM   1602 N N   . TYR   A 1 209 ? -14.279 -13.451 35.057  1.000 39.593  0 209 TYR   A N   1 ? 
ATOM   1603 C CA  . TYR   A 1 209 ? -14.205 -14.210 36.292  1.000 39.069  0 209 TYR   A CA  1 ? 
ATOM   1604 C C   . TYR   A 1 209 ? -12.885 -14.977 36.364  1.000 38.472  0 209 TYR   A C   1 ? 
ATOM   1605 O O   . TYR   A 1 209 ? -12.213 -14.952 37.395  1.000 38.074  0 209 TYR   A O   1 ? 
ATOM   1606 C CB  . TYR   A 1 209 ? -15.446 -15.093 36.382  1.000 38.420  0 209 TYR   A CB  1 ? 
ATOM   1607 C CG  . TYR   A 1 209 ? -16.673 -14.322 36.834  1.000 39.631  0 209 TYR   A CG  1 ? 
ATOM   1608 C CD1 . TYR   A 1 209 ? -16.662 -13.596 38.020  1.000 42.219  0 209 TYR   A CD1 1 ? 
ATOM   1609 C CD2 . TYR   A 1 209 ? -17.842 -14.335 36.092  1.000 40.463  0 209 TYR   A CD2 1 ? 
ATOM   1610 C CE1 . TYR   A 1 209 ? -17.778 -12.904 38.455  1.000 42.124  0 209 TYR   A CE1 1 ? 
ATOM   1611 C CE2 . TYR   A 1 209 ? -18.969 -13.654 36.521  1.000 42.531  0 209 TYR   A CE2 1 ? 
ATOM   1612 C CZ  . TYR   A 1 209 ? -18.937 -12.935 37.703  1.000 41.982  0 209 TYR   A CZ  1 ? 
ATOM   1613 O OH  . TYR   A 1 209 ? -20.038 -12.249 38.120  1.000 40.780  0 209 TYR   A OH  1 ? 
ATOM   1614 N N   . ALA   A 1 210 ? -12.508 -15.629 35.258  1.000 36.331  0 210 ALA   A N   1 ? 
ATOM   1615 C CA  . ALA   A 1 210 ? -11.256 -16.364 35.209  1.000 37.114  0 210 ALA   A CA  1 ? 
ATOM   1616 C C   . ALA   A 1 210 ? -10.095 -15.413 35.473  1.000 40.951  0 210 ALA   A C   1 ? 
ATOM   1617 O O   . ALA   A 1 210 ? -9.114  -15.802 36.100  1.000 41.970  0 210 ALA   A O   1 ? 
ATOM   1618 C CB  . ALA   A 1 210 ? -11.101 -17.048 33.876  1.000 39.092  0 210 ALA   A CB  1 ? 
ATOM   1619 N N   . ALA   A 1 211 ? -10.214 -14.171 34.983  1.000 41.479  0 211 ALA   A N   1 ? 
ATOM   1620 C CA  . ALA   A 1 211 ? -9.173  -13.178 35.178  1.000 40.286  0 211 ALA   A CA  1 ? 
ATOM   1621 C C   . ALA   A 1 211 ? -9.039  -12.879 36.662  1.000 40.202  0 211 ALA   A C   1 ? 
ATOM   1622 O O   . ALA   A 1 211 ? -7.986  -13.075 37.269  1.000 39.118  0 211 ALA   A O   1 ? 
ATOM   1623 C CB  . ALA   A 1 211 ? -9.483  -11.932 34.389  1.000 42.664  0 211 ALA   A CB  1 ? 
ATOM   1624 N N   . VAL   A 1 212 ? -10.139 -12.410 37.238  1.000 44.078  0 212 VAL   A N   1 ? 
ATOM   1625 C CA  . VAL   A 1 212 ? -10.211 -12.199 38.671  1.000 45.636  0 212 VAL   A CA  1 ? 
ATOM   1626 C C   . VAL   A 1 212 ? -9.478  -13.340 39.362  1.000 44.698  0 212 VAL   A C   1 ? 
ATOM   1627 O O   . VAL   A 1 212 ? -8.497  -13.120 40.064  1.000 44.887  0 212 VAL   A O   1 ? 
ATOM   1628 C CB  . VAL   A 1 212 ? -11.675 -12.146 39.141  1.000 45.015  0 212 VAL   A CB  1 ? 
ATOM   1629 C CG1 . VAL   A 1 212 ? -11.781 -12.302 40.647  1.000 45.212  0 212 VAL   A CG1 1 ? 
ATOM   1630 C CG2 . VAL   A 1 212 ? -12.365 -10.879 38.660  1.000 45.956  0 212 VAL   A CG2 1 ? 
ATOM   1631 N N   . ILE   A 1 213 ? -9.960  -14.563 39.116  1.000 43.525  0 213 ILE   A N   1 ? 
ATOM   1632 C CA  . ILE   A 1 213 ? -9.455  -15.733 39.812  1.000 41.021  0 213 ILE   A CA  1 ? 
ATOM   1633 C C   . ILE   A 1 213 ? -7.934  -15.807 39.708  1.000 41.866  0 213 ILE   A C   1 ? 
ATOM   1634 O O   . ILE   A 1 213 ? -7.294  -16.367 40.584  1.000 43.307  0 213 ILE   A O   1 ? 
ATOM   1635 C CB  . ILE   A 1 213 ? -10.108 -17.014 39.276  1.000 36.142  0 213 ILE   A CB  1 ? 
ATOM   1636 C CG1 . ILE   A 1 213 ? -11.597 -17.065 39.631  1.000 37.439  0 213 ILE   A CG1 1 ? 
ATOM   1637 C CG2 . ILE   A 1 213 ? -9.354  -18.227 39.787  1.000 35.744  0 213 ILE   A CG2 1 ? 
ATOM   1638 C CD1 . ILE   A 1 213 ? -12.371 -18.238 39.041  1.000 35.217  0 213 ILE   A CD1 1 ? 
ATOM   1639 N N   . ASN   A 1 214 ? -7.355  -15.249 38.644  1.000 42.513  0 214 ASN   A N   1 ? 
ATOM   1640 C CA  . ASN   A 1 214 ? -5.927  -15.370 38.421  1.000 44.062  0 214 ASN   A CA  1 ? 
ATOM   1641 C C   . ASN   A 1 214 ? -5.210  -14.082 38.801  1.000 49.137  0 214 ASN   A C   1 ? 
ATOM   1642 O O   . ASN   A 1 214 ? -4.020  -13.950 38.553  1.000 54.093  0 214 ASN   A O   1 ? 
ATOM   1643 C CB  . ASN   A 1 214 ? -5.656  -15.823 36.989  1.000 43.180  0 214 ASN   A CB  1 ? 
ATOM   1644 C CG  . ASN   A 1 214 ? -5.775  -17.326 36.868  1.000 41.236  0 214 ASN   A CG  1 ? 
ATOM   1645 O OD1 . ASN   A 1 214 ? -4.807  -18.041 37.102  1.000 42.493  0 214 ASN   A OD1 1 ? 
ATOM   1646 N ND2 . ASN   A 1 214 ? -6.953  -17.817 36.525  1.000 40.809  0 214 ASN   A ND2 1 ? 
ATOM   1647 N N   . GLY   A 1 215 ? -5.926  -13.148 39.429  1.000 55.983  0 215 GLY   A N   1 ? 
ATOM   1648 C CA  . GLY   A 1 215 ? -5.304  -11.951 39.966  1.000 57.198  0 215 GLY   A CA  1 ? 
ATOM   1649 C C   . GLY   A 1 215 ? -4.947  -10.938 38.884  1.000 60.103  0 215 GLY   A C   1 ? 
ATOM   1650 O O   . GLY   A 1 215 ? -4.028  -10.150 39.079  1.000 60.630  0 215 GLY   A O   1 ? 
ATOM   1651 N N   . ASP   A 1 216 ? -5.639  -11.013 37.736  1.000 67.994  0 216 ASP   A N   1 ? 
ATOM   1652 C CA  . ASP   A 1 216 ? -5.861  -9.864  36.863  1.000 70.050  0 216 ASP   A CA  1 ? 
ATOM   1653 C C   . ASP   A 1 216 ? -7.235  -9.296  37.207  1.000 75.197  0 216 ASP   A C   1 ? 
ATOM   1654 O O   . ASP   A 1 216 ? -8.250  -9.855  36.797  1.000 80.011  0 216 ASP   A O   1 ? 
ATOM   1655 C CB  . ASP   A 1 216 ? -5.824  -10.225 35.372  1.000 67.057  0 216 ASP   A CB  1 ? 
ATOM   1656 C CG  . ASP   A 1 216 ? -4.455  -10.159 34.715  1.000 68.087  0 216 ASP   A CG  1 ? 
ATOM   1657 O OD1 . ASP   A 1 216 ? -3.602  -10.994 35.049  1.000 69.286  0 216 ASP   A OD1 1 ? 
ATOM   1658 O OD2 . ASP   A 1 216 ? -4.257  -9.280  33.859  1.000 67.340  0 216 ASP   A OD2 1 ? 
ATOM   1659 N N   . ARG   A 1 217 ? -7.264  -8.208  37.986  1.000 77.616  0 217 ARG   A N   1 ? 
ATOM   1660 C CA  . ARG   A 1 217 ? -8.521  -7.676  38.495  1.000 77.952  0 217 ARG   A CA  1 ? 
ATOM   1661 C C   . ARG   A 1 217 ? -8.577  -6.149  38.385  1.000 68.571  0 217 ARG   A C   1 ? 
ATOM   1662 O O   . ARG   A 1 217 ? -9.496  -5.536  38.919  1.000 68.359  0 217 ARG   A O   1 ? 
ATOM   1663 C CB  . ARG   A 1 217 ? -8.728  -8.141  39.942  1.000 89.260  0 217 ARG   A CB  1 ? 
ATOM   1664 C CG  . ARG   A 1 217 ? -7.481  -8.041  40.811  1.000 103.046 0 217 ARG   A CG  1 ? 
ATOM   1665 C CD  . ARG   A 1 217 ? -7.752  -7.820  42.291  1.000 112.087 0 217 ARG   A CD  1 ? 
ATOM   1666 N NE  . ARG   A 1 217 ? -6.517  -7.436  42.977  1.000 117.010 0 217 ARG   A NE  1 ? 
ATOM   1667 C CZ  . ARG   A 1 217 ? -6.126  -6.187  43.251  1.000 109.906 0 217 ARG   A CZ  1 ? 
ATOM   1668 N NH1 . ARG   A 1 217 ? -4.912  -5.976  43.729  1.000 103.371 0 217 ARG   A NH1 1 ? 
ATOM   1669 N NH2 . ARG   A 1 217 ? -6.909  -5.147  43.007  1.000 108.906 0 217 ARG   A NH2 1 ? 
ATOM   1670 N N   . TRP   A 1 218 ? -7.643  -5.538  37.644  1.000 63.252  0 218 TRP   A N   1 ? 
ATOM   1671 C CA  . TRP   A 1 218 ? -7.571  -4.088  37.552  1.000 60.502  0 218 TRP   A CA  1 ? 
ATOM   1672 C C   . TRP   A 1 218 ? -8.848  -3.526  36.940  1.000 59.227  0 218 TRP   A C   1 ? 
ATOM   1673 O O   . TRP   A 1 218 ? -9.291  -2.451  37.319  1.000 69.975  0 218 TRP   A O   1 ? 
ATOM   1674 C CB  . TRP   A 1 218 ? -6.333  -3.624  36.770  1.000 60.882  0 218 TRP   A CB  1 ? 
ATOM   1675 C CG  . TRP   A 1 218 ? -6.168  -4.223  35.397  1.000 63.443  0 218 TRP   A CG  1 ? 
ATOM   1676 C CD1 . TRP   A 1 218 ? -5.347  -5.261  35.063  1.000 65.322  0 218 TRP   A CD1 1 ? 
ATOM   1677 C CD2 . TRP   A 1 218 ? -6.783  -3.792  34.161  1.000 63.920  0 218 TRP   A CD2 1 ? 
ATOM   1678 N NE1 . TRP   A 1 218 ? -5.425  -5.528  33.723  1.000 64.114  0 218 TRP   A NE1 1 ? 
ATOM   1679 C CE2 . TRP   A 1 218 ? -6.292  -4.641  33.140  1.000 63.830  0 218 TRP   A CE2 1 ? 
ATOM   1680 C CE3 . TRP   A 1 218 ? -7.700  -2.792  33.819  1.000 58.555  0 218 TRP   A CE3 1 ? 
ATOM   1681 C CZ2 . TRP   A 1 218 ? -6.687  -4.516  31.810  1.000 58.200  0 218 TRP   A CZ2 1 ? 
ATOM   1682 C CZ3 . TRP   A 1 218 ? -8.091  -2.674  32.503  1.000 59.046  0 218 TRP   A CZ3 1 ? 
ATOM   1683 C CH2 . TRP   A 1 218 ? -7.586  -3.518  31.514  1.000 58.456  0 218 TRP   A CH2 1 ? 
ATOM   1684 N N   . PHE   A 1 219 ? -9.450  -4.269  36.016  1.000 56.860  0 219 PHE   A N   1 ? 
ATOM   1685 C CA  . PHE   A 1 219 ? -10.620 -3.805  35.285  1.000 57.227  0 219 PHE   A CA  1 ? 
ATOM   1686 C C   . PHE   A 1 219 ? -11.893 -3.862  36.137  1.000 55.607  0 219 PHE   A C   1 ? 
ATOM   1687 O O   . PHE   A 1 219 ? -12.987 -3.630  35.614  1.000 54.276  0 219 PHE   A O   1 ? 
ATOM   1688 C CB  . PHE   A 1 219 ? -10.811 -4.683  34.046  1.000 57.461  0 219 PHE   A CB  1 ? 
ATOM   1689 C CG  . PHE   A 1 219 ? -11.117 -6.113  34.407  1.000 53.285  0 219 PHE   A CG  1 ? 
ATOM   1690 C CD1 . PHE   A 1 219 ? -12.400 -6.496  34.765  1.000 52.383  0 219 PHE   A CD1 1 ? 
ATOM   1691 C CD2 . PHE   A 1 219 ? -10.097 -7.045  34.497  1.000 51.439  0 219 PHE   A CD2 1 ? 
ATOM   1692 C CE1 . PHE   A 1 219 ? -12.663 -7.802  35.145  1.000 56.629  0 219 PHE   A CE1 1 ? 
ATOM   1693 C CE2 . PHE   A 1 219 ? -10.361 -8.350  34.878  1.000 53.761  0 219 PHE   A CE2 1 ? 
ATOM   1694 C CZ  . PHE   A 1 219 ? -11.644 -8.728  35.202  1.000 56.173  0 219 PHE   A CZ  1 ? 
ATOM   1695 N N   . LEU   A 1 220 ? -11.777 -4.232  37.420  1.000 53.205  0 220 LEU   A N   1 ? 
ATOM   1696 C CA  . LEU   A 1 220 ? -12.940 -4.274  38.295  1.000 57.764  0 220 LEU   A CA  1 ? 
ATOM   1697 C C   . LEU   A 1 220 ? -13.373 -2.851  38.628  1.000 61.924  0 220 LEU   A C   1 ? 
ATOM   1698 O O   . LEU   A 1 220 ? -12.538 -1.967  38.790  1.000 58.027  0 220 LEU   A O   1 ? 
ATOM   1699 C CB  . LEU   A 1 220 ? -12.611 -5.068  39.561  1.000 55.233  0 220 LEU   A CB  1 ? 
ATOM   1700 C CG  . LEU   A 1 220 ? -12.591 -6.587  39.391  1.000 55.702  0 220 LEU   A CG  1 ? 
ATOM   1701 C CD1 . LEU   A 1 220 ? -12.224 -7.281  40.692  1.000 55.645  0 220 LEU   A CD1 1 ? 
ATOM   1702 C CD2 . LEU   A 1 220 ? -13.935 -7.103  38.898  1.000 56.181  0 220 LEU   A CD2 1 ? 
ATOM   1703 N N   . ASN   A 1 221 ? -14.686 -2.625  38.704  1.000 71.169  0 221 ASN   A N   1 ? 
ATOM   1704 C CA  . ASN   A 1 221 ? -15.173 -1.258  38.771  1.000 77.721  0 221 ASN   A CA  1 ? 
ATOM   1705 C C   . ASN   A 1 221 ? -16.285 -1.152  39.810  1.000 74.363  0 221 ASN   A C   1 ? 
ATOM   1706 O O   . ASN   A 1 221 ? -17.167 -2.008  39.896  1.000 66.410  0 221 ASN   A O   1 ? 
ATOM   1707 C CB  . ASN   A 1 221 ? -15.637 -0.736  37.407  1.000 80.224  0 221 ASN   A CB  1 ? 
ATOM   1708 C CG  . ASN   A 1 221 ? -14.976 0.571   37.011  1.000 83.172  0 221 ASN   A CG  1 ? 
ATOM   1709 O OD1 . ASN   A 1 221 ? -14.635 0.766   35.846  1.000 90.001  0 221 ASN   A OD1 1 ? 
ATOM   1710 N ND2 . ASN   A 1 221 ? -14.798 1.482   37.956  1.000 81.793  0 221 ASN   A ND2 1 ? 
ATOM   1711 N N   . ARG   A 1 222 ? -16.209 -0.052  40.565  1.000 72.300  0 222 ARG   A N   1 ? 
ATOM   1712 C CA  . ARG   A 1 222 ? -17.160 0.300   41.603  1.000 75.153  0 222 ARG   A CA  1 ? 
ATOM   1713 C C   . ARG   A 1 222 ? -18.591 0.303   41.067  1.000 72.541  0 222 ARG   A C   1 ? 
ATOM   1714 O O   . ARG   A 1 222 ? -19.511 -0.058  41.796  1.000 83.112  0 222 ARG   A O   1 ? 
ATOM   1715 C CB  . ARG   A 1 222 ? -16.798 1.673   42.183  1.000 79.199  0 222 ARG   A CB  1 ? 
ATOM   1716 C CG  . ARG   A 1 222 ? -16.936 2.838   41.211  1.000 83.902  0 222 ARG   A CG  1 ? 
ATOM   1717 C CD  . ARG   A 1 222 ? -16.530 4.170   41.815  1.000 85.610  0 222 ARG   A CD  1 ? 
ATOM   1718 N NE  . ARG   A 1 222 ? -15.125 4.497   41.616  1.000 86.742  0 222 ARG   A NE  1 ? 
ATOM   1719 C CZ  . ARG   A 1 222 ? -14.166 4.326   42.518  1.000 86.983  0 222 ARG   A CZ  1 ? 
ATOM   1720 N NH1 . ARG   A 1 222 ? -12.959 4.823   42.298  1.000 85.308  0 222 ARG   A NH1 1 ? 
ATOM   1721 N NH2 . ARG   A 1 222 ? -14.420 3.678   43.643  1.000 86.663  0 222 ARG   A NH2 1 ? 
ATOM   1722 N N   . PHE   A 1 223 ? -18.780 0.713   39.806  1.000 64.673  0 223 PHE   A N   1 ? 
ATOM   1723 C CA  . PHE   A 1 223 ? -20.120 0.832   39.254  1.000 60.500  0 223 PHE   A CA  1 ? 
ATOM   1724 C C   . PHE   A 1 223 ? -20.776 -0.546  39.244  1.000 52.612  0 223 PHE   A C   1 ? 
ATOM   1725 O O   . PHE   A 1 223 ? -20.102 -1.576  39.244  1.000 50.834  0 223 PHE   A O   1 ? 
ATOM   1726 C CB  . PHE   A 1 223 ? -20.132 1.401   37.830  1.000 63.029  0 223 PHE   A CB  1 ? 
ATOM   1727 C CG  . PHE   A 1 223 ? -19.422 2.715   37.604  1.000 66.526  0 223 PHE   A CG  1 ? 
ATOM   1728 C CD1 . PHE   A 1 223 ? -18.035 2.792   37.609  1.000 67.422  0 223 PHE   A CD1 1 ? 
ATOM   1729 C CD2 . PHE   A 1 223 ? -20.140 3.869   37.313  1.000 71.683  0 223 PHE   A CD2 1 ? 
ATOM   1730 C CE1 . PHE   A 1 223 ? -17.384 3.993   37.355  1.000 70.879  0 223 PHE   A CE1 1 ? 
ATOM   1731 C CE2 . PHE   A 1 223 ? -19.488 5.069   37.052  1.000 71.301  0 223 PHE   A CE2 1 ? 
ATOM   1732 C CZ  . PHE   A 1 223 ? -18.110 5.130   37.076  1.000 69.793  0 223 PHE   A CZ  1 ? 
ATOM   1733 N N   . THR   A 1 224 ? -22.104 -0.537  39.294  1.000 49.317  0 224 THR   A N   1 ? 
ATOM   1734 C CA  . THR   A 1 224 ? -22.905 -1.675  38.897  1.000 50.386  0 224 THR   A CA  1 ? 
ATOM   1735 C C   . THR   A 1 224 ? -23.767 -1.191  37.737  1.000 56.243  0 224 THR   A C   1 ? 
ATOM   1736 O O   . THR   A 1 224 ? -23.635 -0.045  37.317  1.000 59.716  0 224 THR   A O   1 ? 
ATOM   1737 C CB  . THR   A 1 224 ? -23.690 -2.251  40.082  1.000 49.718  0 224 THR   A CB  1 ? 
ATOM   1738 O OG1 . THR   A 1 224 ? -24.192 -3.525  39.682  1.000 49.255  0 224 THR   A OG1 1 ? 
ATOM   1739 C CG2 . THR   A 1 224 ? -24.830 -1.368  40.538  1.000 49.005  0 224 THR   A CG2 1 ? 
ATOM   1740 N N   . THR   A 1 225 ? -24.611 -2.076  37.200  1.000 63.448  0 225 THR   A N   1 ? 
ATOM   1741 C CA  . THR   A 1 225 ? -25.516 -1.713  36.120  1.000 60.823  0 225 THR   A CA  1 ? 
ATOM   1742 C C   . THR   A 1 225 ? -26.768 -2.568  36.244  1.000 57.383  0 225 THR   A C   1 ? 
ATOM   1743 O O   . THR   A 1 225 ? -26.841 -3.424  37.122  1.000 52.599  0 225 THR   A O   1 ? 
ATOM   1744 C CB  . THR   A 1 225 ? -24.845 -1.861  34.745  1.000 61.612  0 225 THR   A CB  1 ? 
ATOM   1745 O OG1 . THR   A 1 225 ? -25.663 -1.232  33.758  1.000 58.042  0 225 THR   A OG1 1 ? 
ATOM   1746 C CG2 . THR   A 1 225 ? -24.598 -3.303  34.353  1.000 63.993  0 225 THR   A CG2 1 ? 
ATOM   1747 N N   . THR   A 1 226 ? -27.742 -2.305  35.365  1.000 59.025  0 226 THR   A N   1 ? 
ATOM   1748 C CA  . THR   A 1 226 ? -28.918 -3.148  35.235  1.000 58.966  0 226 THR   A CA  1 ? 
ATOM   1749 C C   . THR   A 1 226 ? -28.801 -3.964  33.950  1.000 58.535  0 226 THR   A C   1 ? 
ATOM   1750 O O   . THR   A 1 226 ? -27.966 -3.696  33.087  1.000 52.993  0 226 THR   A O   1 ? 
ATOM   1751 C CB  . THR   A 1 226 ? -30.221 -2.335  35.270  1.000 58.734  0 226 THR   A CB  1 ? 
ATOM   1752 O OG1 . THR   A 1 226 ? -30.464 -1.755  33.988  1.000 61.582  0 226 THR   A OG1 1 ? 
ATOM   1753 C CG2 . THR   A 1 226 ? -30.211 -1.243  36.317  1.000 58.689  0 226 THR   A CG2 1 ? 
ATOM   1754 N N   . LEU   A 1 227 ? -29.675 -4.962  33.838  1.000 62.307  0 227 LEU   A N   1 ? 
ATOM   1755 C CA  . LEU   A 1 227 ? -29.646 -5.886  32.721  1.000 62.722  0 227 LEU   A CA  1 ? 
ATOM   1756 C C   . LEU   A 1 227 ? -30.029 -5.148  31.442  1.000 63.971  0 227 LEU   A C   1 ? 
ATOM   1757 O O   . LEU   A 1 227 ? -29.294 -5.208  30.459  1.000 64.393  0 227 LEU   A O   1 ? 
ATOM   1758 C CB  . LEU   A 1 227 ? -30.607 -7.039  33.030  1.000 61.980  0 227 LEU   A CB  1 ? 
ATOM   1759 C CG  . LEU   A 1 227 ? -30.427 -8.297  32.182  1.000 58.232  0 227 LEU   A CG  1 ? 
ATOM   1760 C CD1 . LEU   A 1 227 ? -29.137 -9.018  32.547  1.000 57.137  0 227 LEU   A CD1 1 ? 
ATOM   1761 C CD2 . LEU   A 1 227 ? -31.623 -9.230  32.331  1.000 53.396  0 227 LEU   A CD2 1 ? 
ATOM   1762 N N   . ASN   A 1 228 ? -31.164 -4.432  31.480  1.000 63.827  0 228 ASN   A N   1 ? 
ATOM   1763 C CA  . ASN   A 1 228 ? -31.659 -3.698  30.322  1.000 63.362  0 228 ASN   A CA  1 ? 
ATOM   1764 C C   . ASN   A 1 228 ? -30.649 -2.630  29.914  1.000 59.698  0 228 ASN   A C   1 ? 
ATOM   1765 O O   . ASN   A 1 228 ? -30.311 -2.495  28.745  1.000 53.341  0 228 ASN   A O   1 ? 
ATOM   1766 C CB  . ASN   A 1 228 ? -33.030 -3.070  30.586  1.000 62.337  0 228 ASN   A CB  1 ? 
ATOM   1767 C CG  . ASN   A 1 228 ? -34.122 -4.099  30.793  1.000 59.744  0 228 ASN   A CG  1 ? 
ATOM   1768 O OD1 . ASN   A 1 228 ? -33.856 -5.299  30.831  1.000 56.871  0 228 ASN   A OD1 1 ? 
ATOM   1769 N ND2 . ASN   A 1 228 ? -35.352 -3.637  30.941  1.000 58.534  0 228 ASN   A ND2 1 ? 
ATOM   1770 N N   . ASP   A 1 229 ? -30.174 -1.881  30.904  1.000 67.404  0 229 ASP   A N   1 ? 
ATOM   1771 C CA  . ASP   A 1 229 ? -29.202 -0.823  30.695  1.000 78.661  0 229 ASP   A CA  1 ? 
ATOM   1772 C C   . ASP   A 1 229 ? -27.963 -1.375  29.982  1.000 68.651  0 229 ASP   A C   1 ? 
ATOM   1773 O O   . ASP   A 1 229 ? -27.467 -0.778  29.027  1.000 63.187  0 229 ASP   A O   1 ? 
ATOM   1774 C CB  . ASP   A 1 229 ? -28.868 -0.178  32.044  1.000 95.691  0 229 ASP   A CB  1 ? 
ATOM   1775 C CG  . ASP   A 1 229 ? -28.059 1.105   31.966  1.000 113.374 0 229 ASP   A CG  1 ? 
ATOM   1776 O OD1 . ASP   A 1 229 ? -28.675 2.167   31.724  1.000 116.646 0 229 ASP   A OD1 1 ? 
ATOM   1777 O OD2 . ASP   A 1 229 ? -26.820 1.032   32.158  1.000 127.618 0 229 ASP   A OD2 1 ? 
ATOM   1778 N N   . PHE   A 1 230 ? -27.452 -2.519  30.450  1.000 63.742  0 230 PHE   A N   1 ? 
ATOM   1779 C CA  . PHE   A 1 230 ? -26.203 -3.039  29.922  1.000 59.057  0 230 PHE   A CA  1 ? 
ATOM   1780 C C   . PHE   A 1 230 ? -26.361 -3.520  28.481  1.000 56.539  0 230 PHE   A C   1 ? 
ATOM   1781 O O   . PHE   A 1 230 ? -25.439 -3.370  27.685  1.000 55.274  0 230 PHE   A O   1 ? 
ATOM   1782 C CB  . PHE   A 1 230 ? -25.676 -4.206  30.750  1.000 58.759  0 230 PHE   A CB  1 ? 
ATOM   1783 C CG  . PHE   A 1 230 ? -24.533 -4.908  30.064  1.000 60.325  0 230 PHE   A CG  1 ? 
ATOM   1784 C CD1 . PHE   A 1 230 ? -23.258 -4.360  30.076  1.000 63.562  0 230 PHE   A CD1 1 ? 
ATOM   1785 C CD2 . PHE   A 1 230 ? -24.750 -6.062  29.324  1.000 57.308  0 230 PHE   A CD2 1 ? 
ATOM   1786 C CE1 . PHE   A 1 230 ? -22.208 -4.984  29.414  1.000 60.921  0 230 PHE   A CE1 1 ? 
ATOM   1787 C CE2 . PHE   A 1 230 ? -23.702 -6.682  28.662  1.000 56.683  0 230 PHE   A CE2 1 ? 
ATOM   1788 C CZ  . PHE   A 1 230 ? -22.435 -6.140  28.700  1.000 55.844  0 230 PHE   A CZ  1 ? 
ATOM   1789 N N   . ASN   A 1 231 ? -27.514 -4.125  28.166  1.000 54.572  0 231 ASN   A N   1 ? 
ATOM   1790 C CA  . ASN   A 1 231 ? -27.807 -4.624  26.827  1.000 52.004  0 231 ASN   A CA  1 ? 
ATOM   1791 C C   . ASN   A 1 231 ? -27.859 -3.496  25.794  1.000 54.605  0 231 ASN   A C   1 ? 
ATOM   1792 O O   . ASN   A 1 231 ? -27.430 -3.689  24.657  1.000 48.192  0 231 ASN   A O   1 ? 
ATOM   1793 C CB  . ASN   A 1 231 ? -29.108 -5.427  26.807  1.000 49.057  0 231 ASN   A CB  1 ? 
ATOM   1794 C CG  . ASN   A 1 231 ? -28.965 -6.724  27.569  1.000 49.121  0 231 ASN   A CG  1 ? 
ATOM   1795 O OD1 . ASN   A 1 231 ? -27.862 -7.078  27.975  1.000 51.115  0 231 ASN   A OD1 1 ? 
ATOM   1796 N ND2 . ASN   A 1 231 ? -30.061 -7.436  27.769  1.000 49.790  0 231 ASN   A ND2 1 ? 
ATOM   1797 N N   . LEU   A 1 232 ? -28.386 -2.329  26.183  1.000 59.528  0 232 LEU   A N   1 ? 
ATOM   1798 C CA  . LEU   A 1 232 ? -28.364 -1.161  25.321  1.000 63.596  0 232 LEU   A CA  1 ? 
ATOM   1799 C C   . LEU   A 1 232 ? -26.941 -0.892  24.837  1.000 65.419  0 232 LEU   A C   1 ? 
ATOM   1800 O O   . LEU   A 1 232 ? -26.718 -0.648  23.654  1.000 68.115  0 232 LEU   A O   1 ? 
ATOM   1801 C CB  . LEU   A 1 232 ? -28.885 0.046   26.098  1.000 71.092  0 232 LEU   A CB  1 ? 
ATOM   1802 C CG  . LEU   A 1 232 ? -29.341 1.197   25.207  1.000 81.436  0 232 LEU   A CG  1 ? 
ATOM   1803 C CD1 . LEU   A 1 232 ? -30.807 1.009   24.842  1.000 84.608  0 232 LEU   A CD1 1 ? 
ATOM   1804 C CD2 . LEU   A 1 232 ? -29.088 2.555   25.861  1.000 81.756  0 232 LEU   A CD2 1 ? 
ATOM   1805 N N   . VAL   A 1 233 ? -25.987 -0.939  25.773  1.000 66.906  0 233 VAL   A N   1 ? 
ATOM   1806 C CA  . VAL   A 1 233 ? -24.584 -0.688  25.479  1.000 72.755  0 233 VAL   A CA  1 ? 
ATOM   1807 C C   . VAL   A 1 233 ? -23.964 -1.886  24.756  1.000 71.252  0 233 VAL   A C   1 ? 
ATOM   1808 O O   . VAL   A 1 233 ? -22.971 -1.725  24.048  1.000 74.462  0 233 VAL   A O   1 ? 
ATOM   1809 C CB  . VAL   A 1 233 ? -23.807 -0.350  26.767  1.000 78.364  0 233 VAL   A CB  1 ? 
ATOM   1810 C CG1 . VAL   A 1 233 ? -22.317 -0.148  26.506  1.000 77.981  0 233 VAL   A CG1 1 ? 
ATOM   1811 C CG2 . VAL   A 1 233 ? -24.402 0.864   27.464  1.000 80.485  0 233 VAL   A CG2 1 ? 
ATOM   1812 N N   . ALA   A 1 234 ? -24.526 -3.085  24.950  1.000 65.840  0 234 ALA   A N   1 ? 
ATOM   1813 C CA  . ALA   A 1 234 ? -24.049 -4.278  24.262  1.000 65.763  0 234 ALA   A CA  1 ? 
ATOM   1814 C C   . ALA   A 1 234 ? -24.436 -4.218  22.785  1.000 60.375  0 234 ALA   A C   1 ? 
ATOM   1815 O O   . ALA   A 1 234 ? -23.578 -4.093  21.921  1.000 59.403  0 234 ALA   A O   1 ? 
ATOM   1816 C CB  . ALA   A 1 234 ? -24.590 -5.524  24.928  1.000 63.593  0 234 ALA   A CB  1 ? 
ATOM   1817 N N   . MET   A 1 235 ? -25.739 -4.288  22.509  1.000 60.059  0 235 MET   A N   1 ? 
ATOM   1818 C CA  . MET   A 1 235 ? -26.254 -4.190  21.154  1.000 61.646  0 235 MET   A CA  1 ? 
ATOM   1819 C C   . MET   A 1 235 ? -25.391 -3.230  20.331  1.000 53.042  0 235 MET   A C   1 ? 
ATOM   1820 O O   . MET   A 1 235 ? -25.020 -3.552  19.207  1.000 49.456  0 235 MET   A O   1 ? 
ATOM   1821 C CB  . MET   A 1 235 ? -27.725 -3.750  21.182  1.000 67.298  0 235 MET   A CB  1 ? 
ATOM   1822 C CG  . MET   A 1 235 ? -28.069 -2.542  20.319  1.000 76.578  0 235 MET   A CG  1 ? 
ATOM   1823 S SD  . MET   A 1 235 ? -29.429 -1.570  21.033  1.000 87.702  0 235 MET   A SD  1 ? 
ATOM   1824 C CE  . MET   A 1 235 ? -28.596 -0.029  21.417  1.000 81.694  0 235 MET   A CE  1 ? 
ATOM   1825 N N   . LYS   A 1 236 ? -25.033 -2.073  20.894  1.000 48.530  0 236 LYS   A N   1 ? 
ATOM   1826 C CA  . LYS   A 1 236 ? -24.349 -1.061  20.104  1.000 55.334  0 236 LYS   A CA  1 ? 
ATOM   1827 C C   . LYS   A 1 236 ? -22.896 -1.458  19.834  1.000 52.906  0 236 LYS   A C   1 ? 
ATOM   1828 O O   . LYS   A 1 236 ? -22.309 -0.950  18.883  1.000 51.881  0 236 LYS   A O   1 ? 
ATOM   1829 C CB  . LYS   A 1 236 ? -24.419 0.332   20.747  1.000 63.602  0 236 LYS   A CB  1 ? 
ATOM   1830 C CG  . LYS   A 1 236 ? -23.368 0.642   21.809  1.000 71.592  0 236 LYS   A CG  1 ? 
ATOM   1831 C CD  . LYS   A 1 236 ? -22.873 2.090   21.821  1.000 80.064  0 236 LYS   A CD  1 ? 
ATOM   1832 C CE  . LYS   A 1 236 ? -21.799 2.376   20.788  1.000 83.443  0 236 LYS   A CE  1 ? 
ATOM   1833 N NZ  . LYS   A 1 236 ? -20.981 3.565   21.136  1.000 83.611  0 236 LYS   A NZ  1 ? 
ATOM   1834 N N   . TYR   A 1 237 ? -22.307 -2.329  20.673  1.000 50.696  0 237 TYR   A N   1 ? 
ATOM   1835 C CA  . TYR   A 1 237 ? -20.955 -2.835  20.453  1.000 47.166  0 237 TYR   A CA  1 ? 
ATOM   1836 C C   . TYR   A 1 237 ? -21.018 -4.217  19.797  1.000 47.800  0 237 TYR   A C   1 ? 
ATOM   1837 O O   . TYR   A 1 237 ? -20.015 -4.930  19.740  1.000 43.126  0 237 TYR   A O   1 ? 
ATOM   1838 C CB  . TYR   A 1 237 ? -20.179 -2.830  21.773  1.000 44.810  0 237 TYR   A CB  1 ? 
ATOM   1839 C CG  . TYR   A 1 237 ? -19.625 -1.460  22.125  1.000 50.233  0 237 TYR   A CG  1 ? 
ATOM   1840 C CD1 . TYR   A 1 237 ? -18.501 -0.958  21.480  1.000 53.088  0 237 TYR   A CD1 1 ? 
ATOM   1841 C CD2 . TYR   A 1 237 ? -20.249 -0.648  23.066  1.000 54.485  0 237 TYR   A CD2 1 ? 
ATOM   1842 C CE1 . TYR   A 1 237 ? -17.997 0.298   21.784  1.000 55.986  0 237 TYR   A CE1 1 ? 
ATOM   1843 C CE2 . TYR   A 1 237 ? -19.759 0.614   23.373  1.000 57.643  0 237 TYR   A CE2 1 ? 
ATOM   1844 C CZ  . TYR   A 1 237 ? -18.630 1.091   22.728  1.000 56.511  0 237 TYR   A CZ  1 ? 
ATOM   1845 O OH  . TYR   A 1 237 ? -18.138 2.330   23.020  1.000 53.542  0 237 TYR   A OH  1 ? 
ATOM   1846 N N   . ASN   A 1 238 ? -22.200 -4.557  19.259  1.000 48.124  0 238 ASN   A N   1 ? 
ATOM   1847 C CA  . ASN   A 1 238 ? -22.455 -5.861  18.677  1.000 48.835  0 238 ASN   A CA  1 ? 
ATOM   1848 C C   . ASN   A 1 238 ? -22.049 -6.922  19.685  1.000 46.408  0 238 ASN   A C   1 ? 
ATOM   1849 O O   . ASN   A 1 238 ? -21.042 -7.604  19.518  1.000 52.755  0 238 ASN   A O   1 ? 
ATOM   1850 C CB  . ASN   A 1 238 ? -21.759 -6.054  17.324  1.000 51.649  0 238 ASN   A CB  1 ? 
ATOM   1851 C CG  . ASN   A 1 238 ? -22.582 -5.539  16.158  1.000 53.375  0 238 ASN   A CG  1 ? 
ATOM   1852 O OD1 . ASN   A 1 238 ? -23.754 -5.886  16.011  1.000 53.227  0 238 ASN   A OD1 1 ? 
ATOM   1853 N ND2 . ASN   A 1 238 ? -21.979 -4.717  15.314  1.000 53.342  0 238 ASN   A ND2 1 ? 
ATOM   1854 N N   . TYR   A 1 239 ? -22.834 -7.008  20.751  1.000 40.586  0 239 TYR   A N   1 ? 
ATOM   1855 C CA  . TYR   A 1 239 ? -22.717 -8.100  21.695  1.000 38.350  0 239 TYR   A CA  1 ? 
ATOM   1856 C C   . TYR   A 1 239 ? -24.058 -8.818  21.768  1.000 38.259  0 239 TYR   A C   1 ? 
ATOM   1857 O O   . TYR   A 1 239 ? -25.103 -8.179  21.853  1.000 34.686  0 239 TYR   A O   1 ? 
ATOM   1858 C CB  . TYR   A 1 239 ? -22.283 -7.548  23.051  1.000 36.437  0 239 TYR   A CB  1 ? 
ATOM   1859 C CG  . TYR   A 1 239 ? -20.787 -7.502  23.290  1.000 33.702  0 239 TYR   A CG  1 ? 
ATOM   1860 C CD1 . TYR   A 1 239 ? -19.940 -6.858  22.410  1.000 36.957  0 239 TYR   A CD1 1 ? 
ATOM   1861 C CD2 . TYR   A 1 239 ? -20.230 -8.078  24.414  1.000 32.404  0 239 TYR   A CD2 1 ? 
ATOM   1862 C CE1 . TYR   A 1 239 ? -18.573 -6.792  22.637  1.000 38.343  0 239 TYR   A CE1 1 ? 
ATOM   1863 C CE2 . TYR   A 1 239 ? -18.868 -8.029  24.650  1.000 35.421  0 239 TYR   A CE2 1 ? 
ATOM   1864 C CZ  . TYR   A 1 239 ? -18.030 -7.390  23.757  1.000 36.565  0 239 TYR   A CZ  1 ? 
ATOM   1865 O OH  . TYR   A 1 239 ? -16.678 -7.363  23.969  1.000 36.769  0 239 TYR   A OH  1 ? 
ATOM   1866 N N   . GLU   A 1 240 ? -24.004 -10.152 21.737  1.000 43.566  0 240 GLU   A N   1 ? 
ATOM   1867 C CA  . GLU   A 1 240 ? -25.178 -10.980 21.945  1.000 51.964  0 240 GLU   A CA  1 ? 
ATOM   1868 C C   . GLU   A 1 240 ? -25.931 -10.486 23.181  1.000 53.091  0 240 GLU   A C   1 ? 
ATOM   1869 O O   . GLU   A 1 240 ? -25.331 -10.297 24.236  1.000 50.731  0 240 GLU   A O   1 ? 
ATOM   1870 C CB  . GLU   A 1 240 ? -24.773 -12.452 22.078  1.000 55.469  0 240 GLU   A CB  1 ? 
ATOM   1871 C CG  . GLU   A 1 240 ? -24.406 -13.104 20.752  1.000 58.000  0 240 GLU   A CG  1 ? 
ATOM   1872 C CD  . GLU   A 1 240 ? -25.510 -13.054 19.706  1.000 61.098  0 240 GLU   A CD  1 ? 
ATOM   1873 O OE1 . GLU   A 1 240 ? -26.649 -13.419 20.038  1.000 64.361  0 240 GLU   A OE1 1 ? 
ATOM   1874 O OE2 . GLU   A 1 240 ? -25.234 -12.645 18.560  1.000 61.064  0 240 GLU   A OE2 1 ? 
ATOM   1875 N N   . PRO   A 1 241 ? -27.259 -10.242 23.082  1.000 55.554  0 241 PRO   A N   1 ? 
ATOM   1876 C CA  . PRO   A 1 241 ? -28.073 -9.904  24.247  1.000 59.016  0 241 PRO   A CA  1 ? 
ATOM   1877 C C   . PRO   A 1 241 ? -27.885 -10.935 25.352  1.000 59.230  0 241 PRO   A C   1 ? 
ATOM   1878 O O   . PRO   A 1 241 ? -27.703 -12.114 25.054  1.000 58.174  0 241 PRO   A O   1 ? 
ATOM   1879 C CB  . PRO   A 1 241 ? -29.517 -9.969  23.734  1.000 58.131  0 241 PRO   A CB  1 ? 
ATOM   1880 C CG  . PRO   A 1 241 ? -29.394 -9.714  22.250  1.000 58.860  0 241 PRO   A CG  1 ? 
ATOM   1881 C CD  . PRO   A 1 241 ? -28.053 -10.290 21.847  1.000 56.853  0 241 PRO   A CD  1 ? 
ATOM   1882 N N   . LEU   A 1 242 ? -27.957 -10.474 26.609  1.000 56.235  0 242 LEU   A N   1 ? 
ATOM   1883 C CA  . LEU   A 1 242 ? -27.730 -11.318 27.775  1.000 53.998  0 242 LEU   A CA  1 ? 
ATOM   1884 C C   . LEU   A 1 242 ? -29.058 -11.625 28.473  1.000 50.156  0 242 LEU   A C   1 ? 
ATOM   1885 O O   . LEU   A 1 242 ? -29.813 -10.714 28.803  1.000 46.598  0 242 LEU   A O   1 ? 
ATOM   1886 C CB  . LEU   A 1 242 ? -26.769 -10.571 28.702  1.000 51.129  0 242 LEU   A CB  1 ? 
ATOM   1887 C CG  . LEU   A 1 242 ? -26.077 -11.405 29.772  1.000 49.589  0 242 LEU   A CG  1 ? 
ATOM   1888 C CD1 . LEU   A 1 242 ? -25.009 -12.290 29.162  1.000 51.656  0 242 LEU   A CD1 1 ? 
ATOM   1889 C CD2 . LEU   A 1 242 ? -25.463 -10.501 30.820  1.000 49.158  0 242 LEU   A CD2 1 ? 
ATOM   1890 N N   . THR   A 1 243 ? -29.344 -12.916 28.673  1.000 48.907  0 243 THR   A N   1 ? 
ATOM   1891 C CA  . THR   A 1 243 ? -30.592 -13.332 29.283  1.000 52.039  0 243 THR   A CA  1 ? 
ATOM   1892 C C   . THR   A 1 243 ? -30.378 -13.655 30.753  1.000 54.399  0 243 THR   A C   1 ? 
ATOM   1893 O O   . THR   A 1 243 ? -29.248 -13.731 31.231  1.000 52.378  0 243 THR   A O   1 ? 
ATOM   1894 C CB  . THR   A 1 243 ? -31.198 -14.551 28.581  1.000 54.868  0 243 THR   A CB  1 ? 
ATOM   1895 O OG1 . THR   A 1 243 ? -30.133 -15.461 28.312  1.000 56.885  0 243 THR   A OG1 1 ? 
ATOM   1896 C CG2 . THR   A 1 243 ? -31.925 -14.193 27.304  1.000 55.638  0 243 THR   A CG2 1 ? 
ATOM   1897 N N   . GLN   A 1 244 ? -31.508 -13.843 31.442  1.000 57.708  0 244 GLN   A N   1 ? 
ATOM   1898 C CA  . GLN   A 1 244 ? -31.531 -14.321 32.811  1.000 61.701  0 244 GLN   A CA  1 ? 
ATOM   1899 C C   . GLN   A 1 244 ? -30.824 -15.668 32.880  1.000 62.785  0 244 GLN   A C   1 ? 
ATOM   1900 O O   . GLN   A 1 244 ? -30.119 -15.951 33.846  1.000 63.376  0 244 GLN   A O   1 ? 
ATOM   1901 C CB  . GLN   A 1 244 ? -32.973 -14.455 33.315  1.000 63.143  0 244 GLN   A CB  1 ? 
ATOM   1902 C CG  . GLN   A 1 244 ? -33.070 -14.694 34.817  1.000 64.867  0 244 GLN   A CG  1 ? 
ATOM   1903 C CD  . GLN   A 1 244 ? -32.332 -13.624 35.586  1.000 64.054  0 244 GLN   A CD  1 ? 
ATOM   1904 O OE1 . GLN   A 1 244 ? -32.778 -12.483 35.673  1.000 68.055  0 244 GLN   A OE1 1 ? 
ATOM   1905 N NE2 . GLN   A 1 244 ? -31.175 -13.974 36.123  1.000 61.825  0 244 GLN   A NE2 1 ? 
ATOM   1906 N N   . ASP   A 1 245 ? -31.011 -16.476 31.830  1.000 62.602  0 245 ASP   A N   1 ? 
ATOM   1907 C CA  . ASP   A 1 245 ? -30.451 -17.816 31.769  1.000 59.942  0 245 ASP   A CA  1 ? 
ATOM   1908 C C   . ASP   A 1 245 ? -28.930 -17.736 31.706  1.000 54.869  0 245 ASP   A C   1 ? 
ATOM   1909 O O   . ASP   A 1 245 ? -28.265 -18.633 32.201  1.000 55.460  0 245 ASP   A O   1 ? 
ATOM   1910 C CB  . ASP   A 1 245 ? -31.044 -18.594 30.598  1.000 62.033  0 245 ASP   A CB  1 ? 
ATOM   1911 C CG  . ASP   A 1 245 ? -32.556 -18.457 30.545  1.000 70.550  0 245 ASP   A CG  1 ? 
ATOM   1912 O OD1 . ASP   A 1 245 ? -33.039 -17.298 30.492  1.000 75.550  0 245 ASP   A OD1 1 ? 
ATOM   1913 O OD2 . ASP   A 1 245 ? -33.240 -19.498 30.582  1.000 73.000  0 245 ASP   A OD2 1 ? 
ATOM   1914 N N   . HIS   A 1 246 ? -28.395 -16.652 31.131  1.000 54.114  0 246 HIS   A N   1 ? 
ATOM   1915 C CA  . HIS   A 1 246 ? -26.957 -16.434 31.079  1.000 57.021  0 246 HIS   A CA  1 ? 
ATOM   1916 C C   . HIS   A 1 246 ? -26.408 -16.103 32.464  1.000 53.872  0 246 HIS   A C   1 ? 
ATOM   1917 O O   . HIS   A 1 246 ? -25.294 -16.493 32.805  1.000 56.608  0 246 HIS   A O   1 ? 
ATOM   1918 C CB  . HIS   A 1 246 ? -26.598 -15.315 30.095  1.000 60.530  0 246 HIS   A CB  1 ? 
ATOM   1919 C CG  . HIS   A 1 246 ? -26.939 -15.620 28.675  1.000 64.127  0 246 HIS   A CG  1 ? 
ATOM   1920 N ND1 . HIS   A 1 246 ? -27.835 -16.593 28.285  1.000 70.034  0 246 HIS   A ND1 1 ? 
ATOM   1921 C CD2 . HIS   A 1 246 ? -26.502 -15.051 27.551  1.000 62.792  0 246 HIS   A CD2 1 ? 
ATOM   1922 C CE1 . HIS   A 1 246 ? -27.917 -16.603 26.963  1.000 67.641  0 246 HIS   A CE1 1 ? 
ATOM   1923 N NE2 . HIS   A 1 246 ? -27.113 -15.676 26.501  1.000 64.905  0 246 HIS   A NE2 1 ? 
ATOM   1924 N N   . VAL   A 1 247 ? -27.196 -15.357 33.239  1.000 50.356  0 247 VAL   A N   1 ? 
ATOM   1925 C CA  . VAL   A 1 247 ? -26.835 -14.954 34.587  1.000 44.792  0 247 VAL   A CA  1 ? 
ATOM   1926 C C   . VAL   A 1 247 ? -26.820 -16.192 35.474  1.000 45.532  0 247 VAL   A C   1 ? 
ATOM   1927 O O   . VAL   A 1 247 ? -25.833 -16.479 36.160  1.000 43.935  0 247 VAL   A O   1 ? 
ATOM   1928 C CB  . VAL   A 1 247 ? -27.831 -13.899 35.096  1.000 43.764  0 247 VAL   A CB  1 ? 
ATOM   1929 C CG1 . VAL   A 1 247 ? -27.657 -13.587 36.572  1.000 45.293  0 247 VAL   A CG1 1 ? 
ATOM   1930 C CG2 . VAL   A 1 247 ? -27.748 -12.630 34.263  1.000 44.547  0 247 VAL   A CG2 1 ? 
ATOM   1931 N N   . ASP   A 1 248 ? -27.940 -16.916 35.444  1.000 45.896  0 248 ASP   A N   1 ? 
ATOM   1932 C CA  . ASP   A 1 248 ? -28.025 -18.206 36.097  1.000 47.580  0 248 ASP   A CA  1 ? 
ATOM   1933 C C   . ASP   A 1 248 ? -26.694 -18.912 35.887  1.000 48.857  0 248 ASP   A C   1 ? 
ATOM   1934 O O   . ASP   A 1 248 ? -26.001 -19.236 36.848  1.000 53.736  0 248 ASP   A O   1 ? 
ATOM   1935 C CB  . ASP   A 1 248 ? -29.182 -19.043 35.546  1.000 48.784  0 248 ASP   A CB  1 ? 
ATOM   1936 C CG  . ASP   A 1 248 ? -30.559 -18.455 35.802  1.000 54.917  0 248 ASP   A CG  1 ? 
ATOM   1937 O OD1 . ASP   A 1 248 ? -30.663 -17.567 36.676  1.000 62.588  0 248 ASP   A OD1 1 ? 
ATOM   1938 O OD2 . ASP   A 1 248 ? -31.519 -18.870 35.110  1.000 56.591  0 248 ASP   A OD2 1 ? 
ATOM   1939 N N   . ILE   A 1 249 ? -26.323 -19.085 34.615  1.000 47.298  0 249 ILE   A N   1 ? 
ATOM   1940 C CA  . ILE   A 1 249 ? -25.177 -19.904 34.255  1.000 47.807  0 249 ILE   A CA  1 ? 
ATOM   1941 C C   . ILE   A 1 249 ? -23.930 -19.373 34.958  1.000 44.372  0 249 ILE   A C   1 ? 
ATOM   1942 O O   . ILE   A 1 249 ? -23.104 -20.153 35.410  1.000 41.227  0 249 ILE   A O   1 ? 
ATOM   1943 C CB  . ILE   A 1 249 ? -25.015 -19.964 32.723  1.000 52.860  0 249 ILE   A CB  1 ? 
ATOM   1944 C CG1 . ILE   A 1 249 ? -26.137 -20.776 32.072  1.000 57.126  0 249 ILE   A CG1 1 ? 
ATOM   1945 C CG2 . ILE   A 1 249 ? -23.656 -20.517 32.335  1.000 55.056  0 249 ILE   A CG2 1 ? 
ATOM   1946 C CD1 . ILE   A 1 249 ? -26.291 -20.542 30.578  1.000 56.875  0 249 ILE   A CD1 1 ? 
ATOM   1947 N N   . LEU   A 1 250 ? -23.824 -18.049 35.084  1.000 45.688  0 250 LEU   A N   1 ? 
ATOM   1948 C CA  . LEU   A 1 250 ? -22.634 -17.420 35.640  1.000 47.944  0 250 LEU   A CA  1 ? 
ATOM   1949 C C   . LEU   A 1 250 ? -22.685 -17.377 37.170  1.000 46.438  0 250 LEU   A C   1 ? 
ATOM   1950 O O   . LEU   A 1 250 ? -21.770 -16.840 37.798  1.000 44.581  0 250 LEU   A O   1 ? 
ATOM   1951 C CB  . LEU   A 1 250 ? -22.517 -16.005 35.062  1.000 44.726  0 250 LEU   A CB  1 ? 
ATOM   1952 C CG  . LEU   A 1 250 ? -22.180 -15.915 33.575  1.000 38.920  0 250 LEU   A CG  1 ? 
ATOM   1953 C CD1 . LEU   A 1 250 ? -22.673 -14.605 33.003  1.000 38.914  0 250 LEU   A CD1 1 ? 
ATOM   1954 C CD2 . LEU   A 1 250 ? -20.684 -16.031 33.351  1.000 38.071  0 250 LEU   A CD2 1 ? 
ATOM   1955 N N   . GLY   A 1 251 ? -23.738 -17.954 37.761  1.000 45.574  0 251 GLY   A N   1 ? 
ATOM   1956 C CA  . GLY   A 1 251 ? -23.924 -17.956 39.206  1.000 47.410  0 251 GLY   A CA  1 ? 
ATOM   1957 C C   . GLY   A 1 251 ? -22.706 -18.474 39.975  1.000 48.592  0 251 GLY   A C   1 ? 
ATOM   1958 O O   . GLY   A 1 251 ? -22.064 -17.712 40.699  1.000 51.256  0 251 GLY   A O   1 ? 
ATOM   1959 N N   . PRO   A 1 252 ? -22.361 -19.781 39.854  1.000 45.163  0 252 PRO   A N   1 ? 
ATOM   1960 C CA  . PRO   A 1 252 ? -21.215 -20.371 40.552  1.000 42.693  0 252 PRO   A CA  1 ? 
ATOM   1961 C C   . PRO   A 1 252 ? -19.891 -19.614 40.455  1.000 42.853  0 252 PRO   A C   1 ? 
ATOM   1962 O O   . PRO   A 1 252 ? -19.119 -19.584 41.412  1.000 43.741  0 252 PRO   A O   1 ? 
ATOM   1963 C CB  . PRO   A 1 252 ? -21.075 -21.727 39.852  1.000 42.274  0 252 PRO   A CB  1 ? 
ATOM   1964 C CG  . PRO   A 1 252 ? -22.488 -22.088 39.494  1.000 41.525  0 252 PRO   A CG  1 ? 
ATOM   1965 C CD  . PRO   A 1 252 ? -23.076 -20.774 39.037  1.000 44.366  0 252 PRO   A CD  1 ? 
ATOM   1966 N N   . LEU   A 1 253 ? -19.624 -19.014 39.293  1.000 43.477  0 253 LEU   A N   1 ? 
ATOM   1967 C CA  . LEU   A 1 253 ? -18.512 -18.088 39.182  1.000 46.630  0 253 LEU   A CA  1 ? 
ATOM   1968 C C   . LEU   A 1 253 ? -18.795 -16.901 40.091  1.000 48.350  0 253 LEU   A C   1 ? 
ATOM   1969 O O   . LEU   A 1 253 ? -17.996 -16.590 40.966  1.000 52.118  0 253 LEU   A O   1 ? 
ATOM   1970 C CB  . LEU   A 1 253 ? -18.352 -17.625 37.729  1.000 50.425  0 253 LEU   A CB  1 ? 
ATOM   1971 C CG  . LEU   A 1 253 ? -17.783 -18.638 36.735  1.000 52.199  0 253 LEU   A CG  1 ? 
ATOM   1972 C CD1 . LEU   A 1 253 ? -17.932 -18.126 35.312  1.000 56.126  0 253 LEU   A CD1 1 ? 
ATOM   1973 C CD2 . LEU   A 1 253 ? -16.319 -18.936 37.008  1.000 52.674  0 253 LEU   A CD2 1 ? 
ATOM   1974 N N   . SER   A 1 254 ? -19.949 -16.261 39.869  1.000 51.773  0 254 SER   A N   1 ? 
ATOM   1975 C CA  . SER   A 1 254 ? -20.358 -15.105 40.646  1.000 56.784  0 254 SER   A CA  1 ? 
ATOM   1976 C C   . SER   A 1 254 ? -20.125 -15.379 42.128  1.000 59.391  0 254 SER   A C   1 ? 
ATOM   1977 O O   . SER   A 1 254 ? -19.481 -14.592 42.822  1.000 64.873  0 254 SER   A O   1 ? 
ATOM   1978 C CB  . SER   A 1 254 ? -21.801 -14.751 40.375  1.000 59.627  0 254 SER   A CB  1 ? 
ATOM   1979 O OG  . SER   A 1 254 ? -22.207 -13.625 41.140  1.000 61.014  0 254 SER   A OG  1 ? 
ATOM   1980 N N   . ALA   A 1 255 ? -20.639 -16.519 42.594  1.000 57.375  0 255 ALA   A N   1 ? 
ATOM   1981 C CA  . ALA   A 1 255 ? -20.556 -16.884 43.998  1.000 59.171  0 255 ALA   A CA  1 ? 
ATOM   1982 C C   . ALA   A 1 255 ? -19.100 -16.947 44.441  1.000 58.000  0 255 ALA   A C   1 ? 
ATOM   1983 O O   . ALA   A 1 255 ? -18.712 -16.307 45.413  1.000 60.008  0 255 ALA   A O   1 ? 
ATOM   1984 C CB  . ALA   A 1 255 ? -21.239 -18.209 44.219  1.000 60.693  0 255 ALA   A CB  1 ? 
ATOM   1985 N N   . GLN   A 1 256 ? -18.316 -17.738 43.709  1.000 57.533  0 256 GLN   A N   1 ? 
ATOM   1986 C CA  . GLN   A 1 256 ? -16.961 -18.072 44.099  1.000 58.325  0 256 GLN   A CA  1 ? 
ATOM   1987 C C   . GLN   A 1 256 ? -16.107 -16.818 44.240  1.000 57.807  0 256 GLN   A C   1 ? 
ATOM   1988 O O   . GLN   A 1 256 ? -15.362 -16.693 45.210  1.000 62.156  0 256 GLN   A O   1 ? 
ATOM   1989 C CB  . GLN   A 1 256 ? -16.343 -18.988 43.048  1.000 62.904  0 256 GLN   A CB  1 ? 
ATOM   1990 C CG  . GLN   A 1 256 ? -14.892 -19.340 43.329  1.000 64.457  0 256 GLN   A CG  1 ? 
ATOM   1991 C CD  . GLN   A 1 256 ? -14.254 -20.042 42.157  1.000 68.434  0 256 GLN   A CD  1 ? 
ATOM   1992 O OE1 . GLN   A 1 256 ? -14.900 -20.324 41.151  1.000 72.372  0 256 GLN   A OE1 1 ? 
ATOM   1993 N NE2 . GLN   A 1 256 ? -12.969 -20.329 42.277  1.000 71.857  0 256 GLN   A NE2 1 ? 
ATOM   1994 N N   . THR   A 1 257 ? -16.212 -15.917 43.254  1.000 53.821  0 257 THR   A N   1 ? 
ATOM   1995 C CA  . THR   A 1 257 ? -15.349 -14.746 43.168  1.000 53.529  0 257 THR   A CA  1 ? 
ATOM   1996 C C   . THR   A 1 257 ? -15.866 -13.610 44.057  1.000 52.634  0 257 THR   A C   1 ? 
ATOM   1997 O O   . THR   A 1 257 ? -15.170 -12.617 44.268  1.000 47.673  0 257 THR   A O   1 ? 
ATOM   1998 C CB  . THR   A 1 257 ? -15.193 -14.309 41.703  1.000 51.489  0 257 THR   A CB  1 ? 
ATOM   1999 O OG1 . THR   A 1 257 ? -16.412 -14.576 41.010  1.000 51.816  0 257 THR   A OG1 1 ? 
ATOM   2000 C CG2 . THR   A 1 257 ? -14.080 -15.031 40.978  1.000 50.035  0 257 THR   A CG2 1 ? 
ATOM   2001 N N   . GLY   A 1 258 ? -17.101 -13.749 44.556  1.000 53.092  0 258 GLY   A N   1 ? 
ATOM   2002 C CA  . GLY   A 1 258 ? -17.723 -12.724 45.373  1.000 50.842  0 258 GLY   A CA  1 ? 
ATOM   2003 C C   . GLY   A 1 258 ? -18.205 -11.530 44.550  1.000 52.349  0 258 GLY   A C   1 ? 
ATOM   2004 O O   . GLY   A 1 258 ? -18.688 -10.562 45.133  1.000 55.840  0 258 GLY   A O   1 ? 
ATOM   2005 N N   . ILE   A 1 259 ? -18.097 -11.601 43.211  1.000 49.095  0 259 ILE   A N   1 ? 
ATOM   2006 C CA  . ILE   A 1 259 ? -18.506 -10.501 42.345  1.000 46.723  0 259 ILE   A CA  1 ? 
ATOM   2007 C C   . ILE   A 1 259 ? -19.850 -10.834 41.700  1.000 51.463  0 259 ILE   A C   1 ? 
ATOM   2008 O O   . ILE   A 1 259 ? -19.987 -11.822 40.983  1.000 51.888  0 259 ILE   A O   1 ? 
ATOM   2009 C CB  . ILE   A 1 259 ? -17.438 -10.169 41.284  1.000 41.656  0 259 ILE   A CB  1 ? 
ATOM   2010 C CG1 . ILE   A 1 259 ? -16.106 -9.808  41.937  1.000 41.203  0 259 ILE   A CG1 1 ? 
ATOM   2011 C CG2 . ILE   A 1 259 ? -17.905 -9.066  40.339  1.000 39.814  0 259 ILE   A CG2 1 ? 
ATOM   2012 C CD1 . ILE   A 1 259 ? -14.990 -9.622  40.955  1.000 41.319  0 259 ILE   A CD1 1 ? 
ATOM   2013 N N   . ALA   A 1 260 ? -20.835 -9.966  41.949  1.000 54.864  0 260 ALA   A N   1 ? 
ATOM   2014 C CA  . ALA   A 1 260 ? -22.158 -10.105 41.370  1.000 52.348  0 260 ALA   A CA  1 ? 
ATOM   2015 C C   . ALA   A 1 260 ? -22.075 -9.966  39.858  1.000 52.696  0 260 ALA   A C   1 ? 
ATOM   2016 O O   . ALA   A 1 260 ? -21.280 -9.194  39.322  1.000 48.530  0 260 ALA   A O   1 ? 
ATOM   2017 C CB  . ALA   A 1 260 ? -23.085 -9.067  41.946  1.000 52.733  0 260 ALA   A CB  1 ? 
ATOM   2018 N N   . VAL   A 1 261 ? -22.962 -10.697 39.191  1.000 57.033  0 261 VAL   A N   1 ? 
ATOM   2019 C CA  . VAL   A 1 261 ? -23.015 -10.718 37.741  1.000 59.112  0 261 VAL   A CA  1 ? 
ATOM   2020 C C   . VAL   A 1 261 ? -23.038 -9.287  37.198  1.000 57.421  0 261 VAL   A C   1 ? 
ATOM   2021 O O   . VAL   A 1 261 ? -22.192 -8.907  36.380  1.000 49.907  0 261 VAL   A O   1 ? 
ATOM   2022 C CB  . VAL   A 1 261 ? -24.230 -11.555 37.303  1.000 58.976  0 261 VAL   A CB  1 ? 
ATOM   2023 C CG1 . VAL   A 1 261 ? -24.604 -11.325 35.847  1.000 62.025  0 261 VAL   A CG1 1 ? 
ATOM   2024 C CG2 . VAL   A 1 261 ? -23.987 -13.031 37.583  1.000 57.106  0 261 VAL   A CG2 1 ? 
ATOM   2025 N N   . LEU   A 1 262 ? -24.000 -8.494  37.690  1.000 55.272  0 262 LEU   A N   1 ? 
ATOM   2026 C CA  . LEU   A 1 262 ? -24.269 -7.172  37.146  1.000 52.324  0 262 LEU   A CA  1 ? 
ATOM   2027 C C   . LEU   A 1 262 ? -23.124 -6.207  37.444  1.000 49.357  0 262 LEU   A C   1 ? 
ATOM   2028 O O   . LEU   A 1 262 ? -22.937 -5.220  36.733  1.000 48.069  0 262 LEU   A O   1 ? 
ATOM   2029 C CB  . LEU   A 1 262 ? -25.598 -6.670  37.714  1.000 52.346  0 262 LEU   A CB  1 ? 
ATOM   2030 C CG  . LEU   A 1 262 ? -26.831 -7.045  36.896  1.000 54.645  0 262 LEU   A CG  1 ? 
ATOM   2031 C CD1 . LEU   A 1 262 ? -28.105 -6.563  37.575  1.000 53.280  0 262 LEU   A CD1 1 ? 
ATOM   2032 C CD2 . LEU   A 1 262 ? -26.737 -6.458  35.488  1.000 57.380  0 262 LEU   A CD2 1 ? 
ATOM   2033 N N   . ASP   A 1 263 ? -22.352 -6.498  38.492  1.000 48.029  0 263 ASP   A N   1 ? 
ATOM   2034 C CA  . ASP   A 1 263 ? -21.162 -5.716  38.767  1.000 52.213  0 263 ASP   A CA  1 ? 
ATOM   2035 C C   . ASP   A 1 263 ? -20.088 -6.075  37.755  1.000 54.663  0 263 ASP   A C   1 ? 
ATOM   2036 O O   . ASP   A 1 263 ? -19.282 -5.230  37.371  1.000 60.968  0 263 ASP   A O   1 ? 
ATOM   2037 C CB  . ASP   A 1 263 ? -20.611 -5.963  40.168  1.000 56.294  0 263 ASP   A CB  1 ? 
ATOM   2038 C CG  . ASP   A 1 263 ? -21.556 -5.581  41.293  1.000 54.746  0 263 ASP   A CG  1 ? 
ATOM   2039 O OD1 . ASP   A 1 263 ? -22.638 -5.010  41.000  1.000 48.640  0 263 ASP   A OD1 1 ? 
ATOM   2040 O OD2 . ASP   A 1 263 ? -21.193 -5.868  42.455  1.000 55.370  0 263 ASP   A OD2 1 ? 
ATOM   2041 N N   . MET   A 1 264 ? -20.074 -7.340  37.334  1.000 55.159  0 264 MET   A N   1 ? 
ATOM   2042 C CA  . MET   A 1 264 ? -19.143 -7.737  36.294  1.000 54.065  0 264 MET   A CA  1 ? 
ATOM   2043 C C   . MET   A 1 264 ? -19.583 -7.137  34.956  1.000 49.004  0 264 MET   A C   1 ? 
ATOM   2044 O O   . MET   A 1 264 ? -18.740 -6.719  34.170  1.000 45.015  0 264 MET   A O   1 ? 
ATOM   2045 C CB  . MET   A 1 264 ? -19.025 -9.260  36.199  1.000 54.432  0 264 MET   A CB  1 ? 
ATOM   2046 C CG  . MET   A 1 264 ? -17.854 -9.705  35.352  1.000 54.595  0 264 MET   A CG  1 ? 
ATOM   2047 S SD  . MET   A 1 264 ? -16.257 -8.992  35.863  1.000 54.691  0 264 MET   A SD  1 ? 
ATOM   2048 C CE  . MET   A 1 264 ? -15.623 -10.344 36.855  1.000 53.790  0 264 MET   A CE  1 ? 
ATOM   2049 N N   . CYS   A 1 265 ? -20.902 -7.059  34.726  1.000 46.716  0 265 CYS   A N   1 ? 
ATOM   2050 C CA  . CYS   A 1 265 ? -21.460 -6.388  33.561  1.000 44.876  0 265 CYS   A CA  1 ? 
ATOM   2051 C C   . CYS   A 1 265 ? -21.174 -4.892  33.566  1.000 45.596  0 265 CYS   A C   1 ? 
ATOM   2052 O O   . CYS   A 1 265 ? -21.034 -4.280  32.509  1.000 45.285  0 265 CYS   A O   1 ? 
ATOM   2053 C CB  . CYS   A 1 265 ? -22.961 -6.584  33.503  1.000 46.268  0 265 CYS   A CB  1 ? 
ATOM   2054 S SG  . CYS   A 1 265 ? -23.370 -8.341  33.496  1.000 59.185  0 265 CYS   A SG  1 ? 
ATOM   2055 N N   . ALA   A 1 266 ? -21.127 -4.301  34.758  1.000 48.691  0 266 ALA   A N   1 ? 
ATOM   2056 C CA  . ALA   A 1 266 ? -20.712 -2.916  34.885  1.000 53.004  0 266 ALA   A CA  1 ? 
ATOM   2057 C C   . ALA   A 1 266 ? -19.252 -2.750  34.452  1.000 56.609  0 266 ALA   A C   1 ? 
ATOM   2058 O O   . ALA   A 1 266 ? -18.944 -1.829  33.691  1.000 54.568  0 266 ALA   A O   1 ? 
ATOM   2059 C CB  . ALA   A 1 266 ? -20.931 -2.456  36.304  1.000 54.367  0 266 ALA   A CB  1 ? 
ATOM   2060 N N   . SER   A 1 267 ? -18.361 -3.630  34.949  1.000 58.030  0 267 SER   A N   1 ? 
ATOM   2061 C CA  . SER   A 1 267 ? -16.934 -3.534  34.666  1.000 55.242  0 267 SER   A CA  1 ? 
ATOM   2062 C C   . SER   A 1 267 ? -16.684 -3.701  33.170  1.000 58.750  0 267 SER   A C   1 ? 
ATOM   2063 O O   . SER   A 1 267 ? -15.829 -3.017  32.612  1.000 67.632  0 267 SER   A O   1 ? 
ATOM   2064 C CB  . SER   A 1 267 ? -16.128 -4.517  35.476  1.000 53.460  0 267 SER   A CB  1 ? 
ATOM   2065 O OG  . SER   A 1 267 ? -15.933 -4.038  36.800  1.000 50.776  0 267 SER   A OG  1 ? 
ATOM   2066 N N   . LEU   A 1 268 ? -17.468 -4.577  32.527  1.000 59.610  0 268 LEU   A N   1 ? 
ATOM   2067 C CA  . LEU   A 1 268 ? -17.349 -4.843  31.098  1.000 58.394  0 268 LEU   A CA  1 ? 
ATOM   2068 C C   . LEU   A 1 268 ? -17.715 -3.595  30.295  1.000 56.357  0 268 LEU   A C   1 ? 
ATOM   2069 O O   . LEU   A 1 268 ? -16.879 -3.063  29.568  1.000 50.869  0 268 LEU   A O   1 ? 
ATOM   2070 C CB  . LEU   A 1 268 ? -18.244 -6.039  30.745  1.000 57.153  0 268 LEU   A CB  1 ? 
ATOM   2071 C CG  . LEU   A 1 268 ? -18.381 -6.380  29.258  1.000 57.487  0 268 LEU   A CG  1 ? 
ATOM   2072 C CD1 . LEU   A 1 268 ? -17.027 -6.540  28.583  1.000 57.183  0 268 LEU   A CD1 1 ? 
ATOM   2073 C CD2 . LEU   A 1 268 ? -19.192 -7.650  29.074  1.000 54.330  0 268 LEU   A CD2 1 ? 
ATOM   2074 N N   . LYS   A 1 269 ? -18.961 -3.133  30.459  1.000 55.910  0 269 LYS   A N   1 ? 
ATOM   2075 C CA  . LYS   A 1 269 ? -19.457 -1.910  29.843  1.000 59.684  0 269 LYS   A CA  1 ? 
ATOM   2076 C C   . LYS   A 1 269 ? -18.376 -0.828  29.783  1.000 58.471  0 269 LYS   A C   1 ? 
ATOM   2077 O O   . LYS   A 1 269 ? -18.178 -0.204  28.744  1.000 54.811  0 269 LYS   A O   1 ? 
ATOM   2078 C CB  . LYS   A 1 269 ? -20.689 -1.436  30.621  1.000 61.513  0 269 LYS   A CB  1 ? 
ATOM   2079 C CG  . LYS   A 1 269 ? -21.138 0.004   30.401  1.000 62.364  0 269 LYS   A CG  1 ? 
ATOM   2080 C CD  . LYS   A 1 269 ? -22.577 0.216   30.849  1.000 65.848  0 269 LYS   A CD  1 ? 
ATOM   2081 C CE  . LYS   A 1 269 ? -22.925 1.650   31.188  1.000 66.866  0 269 LYS   A CE  1 ? 
ATOM   2082 N NZ  . LYS   A 1 269 ? -24.363 1.779   31.521  1.000 66.730  0 269 LYS   A NZ  1 ? 
ATOM   2083 N N   . GLU   A 1 270 ? -17.671 -0.593  30.892  1.000 58.800  0 270 GLU   A N   1 ? 
ATOM   2084 C CA  . GLU   A 1 270 ? -16.711 0.497   30.914  1.000 65.997  0 270 GLU   A CA  1 ? 
ATOM   2085 C C   . GLU   A 1 270 ? -15.521 0.146   30.028  1.000 62.939  0 270 GLU   A C   1 ? 
ATOM   2086 O O   . GLU   A 1 270 ? -14.868 1.037   29.500  1.000 62.167  0 270 GLU   A O   1 ? 
ATOM   2087 C CB  . GLU   A 1 270 ? -16.289 0.847   32.343  1.000 75.356  0 270 GLU   A CB  1 ? 
ATOM   2088 C CG  . GLU   A 1 270 ? -17.411 1.455   33.185  1.000 83.926  0 270 GLU   A CG  1 ? 
ATOM   2089 C CD  . GLU   A 1 270 ? -18.226 2.578   32.547  1.000 90.218  0 270 GLU   A CD  1 ? 
ATOM   2090 O OE1 . GLU   A 1 270 ? -19.484 2.507   32.600  1.000 82.959  0 270 GLU   A OE1 1 ? 
ATOM   2091 O OE2 . GLU   A 1 270 ? -17.611 3.525   31.990  1.000 94.347  0 270 GLU   A OE2 1 ? 
ATOM   2092 N N   . LEU   A 1 271 ? -15.252 -1.150  29.849  1.000 60.217  0 271 LEU   A N   1 ? 
ATOM   2093 C CA  . LEU   A 1 271 ? -14.177 -1.574  28.966  1.000 58.126  0 271 LEU   A CA  1 ? 
ATOM   2094 C C   . LEU   A 1 271 ? -14.582 -1.388  27.502  1.000 54.792  0 271 LEU   A C   1 ? 
ATOM   2095 O O   . LEU   A 1 271 ? -13.717 -1.136  26.661  1.000 53.868  0 271 LEU   A O   1 ? 
ATOM   2096 C CB  . LEU   A 1 271 ? -13.812 -3.030  29.273  1.000 57.927  0 271 LEU   A CB  1 ? 
ATOM   2097 C CG  . LEU   A 1 271 ? -12.983 -3.256  30.539  1.000 57.103  0 271 LEU   A CG  1 ? 
ATOM   2098 C CD1 . LEU   A 1 271 ? -12.932 -4.736  30.889  1.000 55.374  0 271 LEU   A CD1 1 ? 
ATOM   2099 C CD2 . LEU   A 1 271 ? -11.568 -2.703  30.386  1.000 55.914  0 271 LEU   A CD2 1 ? 
ATOM   2100 N N   . LEU   A 1 272 ? -15.886 -1.519  27.207  1.000 51.323  0 272 LEU   A N   1 ? 
ATOM   2101 C CA  . LEU   A 1 272 ? -16.407 -1.227  25.877  1.000 53.306  0 272 LEU   A CA  1 ? 
ATOM   2102 C C   . LEU   A 1 272 ? -16.274 0.264   25.591  1.000 54.330  0 272 LEU   A C   1 ? 
ATOM   2103 O O   . LEU   A 1 272 ? -15.744 0.657   24.552  1.000 55.275  0 272 LEU   A O   1 ? 
ATOM   2104 C CB  . LEU   A 1 272 ? -17.879 -1.636  25.773  1.000 51.866  0 272 LEU   A CB  1 ? 
ATOM   2105 C CG  . LEU   A 1 272 ? -18.179 -3.123  25.932  1.000 50.569  0 272 LEU   A CG  1 ? 
ATOM   2106 C CD1 . LEU   A 1 272 ? -19.650 -3.402  25.656  1.000 50.976  0 272 LEU   A CD1 1 ? 
ATOM   2107 C CD2 . LEU   A 1 272 ? -17.301 -3.957  25.017  1.000 50.454  0 272 LEU   A CD2 1 ? 
ATOM   2108 N N   . GLN   A 1 273 ? -16.751 1.074   26.541  1.000 52.369  0 273 GLN   A N   1 ? 
ATOM   2109 C CA  . GLN   A 1 273 ? -16.800 2.515   26.377  1.000 52.982  0 273 GLN   A CA  1 ? 
ATOM   2110 C C   . GLN   A 1 273 ? -15.399 3.125   26.394  1.000 55.098  0 273 GLN   A C   1 ? 
ATOM   2111 O O   . GLN   A 1 273 ? -15.214 4.190   25.819  1.000 57.600  0 273 GLN   A O   1 ? 
ATOM   2112 C CB  . GLN   A 1 273 ? -17.672 3.130   27.469  1.000 52.930  0 273 GLN   A CB  1 ? 
ATOM   2113 C CG  . GLN   A 1 273 ? -19.156 2.835   27.279  1.000 53.588  0 273 GLN   A CG  1 ? 
ATOM   2114 C CD  . GLN   A 1 273 ? -20.012 3.119   28.492  1.000 53.437  0 273 GLN   A CD  1 ? 
ATOM   2115 O OE1 . GLN   A 1 273 ? -21.200 2.802   28.510  1.000 49.821  0 273 GLN   A OE1 1 ? 
ATOM   2116 N NE2 . GLN   A 1 273 ? -19.423 3.692   29.531  1.000 56.185  0 273 GLN   A NE2 1 ? 
ATOM   2117 N N   . ASN   A 1 274 ? -14.423 2.465   27.039  1.000 56.820  0 274 ASN   A N   1 ? 
ATOM   2118 C CA  . ASN   A 1 274 ? -13.129 3.082   27.313  1.000 56.665  0 274 ASN   A CA  1 ? 
ATOM   2119 C C   . ASN   A 1 274 ? -11.979 2.259   26.743  1.000 54.249  0 274 ASN   A C   1 ? 
ATOM   2120 O O   . ASN   A 1 274 ? -10.819 2.625   26.919  1.000 52.260  0 274 ASN   A O   1 ? 
ATOM   2121 C CB  . ASN   A 1 274 ? -12.895 3.287   28.816  1.000 60.893  0 274 ASN   A CB  1 ? 
ATOM   2122 C CG  . ASN   A 1 274 ? -13.995 4.087   29.487  1.000 62.440  0 274 ASN   A CG  1 ? 
ATOM   2123 O OD1 . ASN   A 1 274 ? -14.737 3.572   30.323  1.000 64.422  0 274 ASN   A OD1 1 ? 
ATOM   2124 N ND2 . ASN   A 1 274 ? -14.123 5.348   29.114  1.000 63.612  0 274 ASN   A ND2 1 ? 
ATOM   2125 N N   . GLY   A 1 275 ? -12.295 1.150   26.067  1.000 57.008  0 275 GLY   A N   1 ? 
ATOM   2126 C CA  . GLY   A 1 275 ? -11.261 0.271   25.553  1.000 57.909  0 275 GLY   A CA  1 ? 
ATOM   2127 C C   . GLY   A 1 275 ? -10.369 -0.260  26.670  1.000 59.746  0 275 GLY   A C   1 ? 
ATOM   2128 O O   . GLY   A 1 275 ? -10.660 -0.088  27.851  1.000 57.248  0 275 GLY   A O   1 ? 
ATOM   2129 N N   . MET   A 1 276 ? -9.289  -0.930  26.267  1.000 65.523  0 276 MET   A N   1 ? 
ATOM   2130 C CA  . MET   A 1 276 ? -8.324  -1.502  27.191  1.000 69.991  0 276 MET   A CA  1 ? 
ATOM   2131 C C   . MET   A 1 276 ? -7.151  -0.550  27.379  1.000 65.299  0 276 MET   A C   1 ? 
ATOM   2132 O O   . MET   A 1 276 ? -6.260  -0.810  28.186  1.000 58.984  0 276 MET   A O   1 ? 
ATOM   2133 C CB  . MET   A 1 276 ? -7.796  -2.849  26.685  1.000 75.308  0 276 MET   A CB  1 ? 
ATOM   2134 C CG  . MET   A 1 276 ? -7.735  -3.908  27.767  1.000 78.294  0 276 MET   A CG  1 ? 
ATOM   2135 S SD  . MET   A 1 276 ? -7.794  -5.596  27.133  1.000 81.800  0 276 MET   A SD  1 ? 
ATOM   2136 C CE  . MET   A 1 276 ? -9.465  -5.638  26.484  1.000 79.663  0 276 MET   A CE  1 ? 
ATOM   2137 N N   . ASN   A 1 277 ? -7.133  0.523   26.592  1.000 66.708  0 277 ASN   A N   1 ? 
ATOM   2138 C CA  . ASN   A 1 277 ? -6.233  1.619   26.866  1.000 71.391  0 277 ASN   A CA  1 ? 
ATOM   2139 C C   . ASN   A 1 277 ? -4.809  1.085   27.028  1.000 69.418  0 277 ASN   A C   1 ? 
ATOM   2140 O O   . ASN   A 1 277 ? -4.048  1.611   27.830  1.000 77.077  0 277 ASN   A O   1 ? 
ATOM   2141 C CB  . ASN   A 1 277 ? -6.714  2.367   28.113  1.000 74.990  0 277 ASN   A CB  1 ? 
ATOM   2142 C CG  . ASN   A 1 277 ? -6.282  3.817   28.161  1.000 87.088  0 277 ASN   A CG  1 ? 
ATOM   2143 O OD1 . ASN   A 1 277 ? -5.572  4.292   27.276  1.000 88.513  0 277 ASN   A OD1 1 ? 
ATOM   2144 N ND2 . ASN   A 1 277 ? -6.708  4.530   29.193  1.000 95.160  0 277 ASN   A ND2 1 ? 
ATOM   2145 N N   . GLY   A 1 278 ? -4.451  0.028   26.289  1.000 69.731  0 278 GLY   A N   1 ? 
ATOM   2146 C CA  . GLY   A 1 278 ? -3.081  -0.470  26.286  1.000 71.520  0 278 GLY   A CA  1 ? 
ATOM   2147 C C   . GLY   A 1 278 ? -2.899  -1.758  27.090  1.000 69.807  0 278 GLY   A C   1 ? 
ATOM   2148 O O   . GLY   A 1 278 ? -2.221  -2.673  26.632  1.000 67.056  0 278 GLY   A O   1 ? 
ATOM   2149 N N   . ARG   A 1 279 ? -3.496  -1.815  28.288  1.000 68.937  0 279 ARG   A N   1 ? 
ATOM   2150 C CA  . ARG   A 1 279 ? -3.327  -2.935  29.200  1.000 67.956  0 279 ARG   A CA  1 ? 
ATOM   2151 C C   . ARG   A 1 279 ? -3.803  -4.243  28.581  1.000 60.769  0 279 ARG   A C   1 ? 
ATOM   2152 O O   . ARG   A 1 279 ? -4.484  -4.249  27.560  1.000 59.523  0 279 ARG   A O   1 ? 
ATOM   2153 C CB  . ARG   A 1 279 ? -4.149  -2.728  30.473  1.000 75.377  0 279 ARG   A CB  1 ? 
ATOM   2154 C CG  . ARG   A 1 279 ? -3.578  -1.692  31.424  1.000 85.049  0 279 ARG   A CG  1 ? 
ATOM   2155 C CD  . ARG   A 1 279 ? -4.695  -1.075  32.235  1.000 97.965  0 279 ARG   A CD  1 ? 
ATOM   2156 N NE  . ARG   A 1 279 ? -5.599  -0.303  31.386  1.000 111.598 0 279 ARG   A NE  1 ? 
ATOM   2157 C CZ  . ARG   A 1 279 ? -6.541  0.532   31.822  1.000 121.707 0 279 ARG   A CZ  1 ? 
ATOM   2158 N NH1 . ARG   A 1 279 ? -6.607  0.867   33.100  1.000 119.154 0 279 ARG   A NH1 1 ? 
ATOM   2159 N NH2 . ARG   A 1 279 ? -7.398  1.062   30.964  1.000 124.752 0 279 ARG   A NH2 1 ? 
ATOM   2160 N N   . THR   A 1 280 ? -3.461  -5.339  29.267  1.000 58.634  0 280 THR   A N   1 ? 
ATOM   2161 C CA  . THR   A 1 280 ? -3.838  -6.686  28.878  1.000 56.651  0 280 THR   A CA  1 ? 
ATOM   2162 C C   . THR   A 1 280 ? -4.582  -7.373  30.018  1.000 53.459  0 280 THR   A C   1 ? 
ATOM   2163 O O   . THR   A 1 280 ? -4.336  -7.081  31.185  1.000 50.691  0 280 THR   A O   1 ? 
ATOM   2164 C CB  . THR   A 1 280 ? -2.592  -7.507  28.536  1.000 56.624  0 280 THR   A CB  1 ? 
ATOM   2165 O OG1 . THR   A 1 280 ? -1.834  -7.605  29.743  1.000 58.646  0 280 THR   A OG1 1 ? 
ATOM   2166 C CG2 . THR   A 1 280 ? -1.762  -6.880  27.438  1.000 57.503  0 280 THR   A CG2 1 ? 
ATOM   2167 N N   . ILE   A 1 281 ? -5.469  -8.307  29.653  1.000 52.429  0 281 ILE   A N   1 ? 
ATOM   2168 C CA  . ILE   A 1 281 ? -6.101  -9.209  30.600  1.000 49.061  0 281 ILE   A CA  1 ? 
ATOM   2169 C C   . ILE   A 1 281 ? -5.790  -10.646 30.193  1.000 49.905  0 281 ILE   A C   1 ? 
ATOM   2170 O O   . ILE   A 1 281 ? -6.106  -11.069 29.082  1.000 45.487  0 281 ILE   A O   1 ? 
ATOM   2171 C CB  . ILE   A 1 281 ? -7.623  -8.994  30.659  1.000 48.837  0 281 ILE   A CB  1 ? 
ATOM   2172 C CG1 . ILE   A 1 281 ? -8.002  -7.547  30.980  1.000 48.760  0 281 ILE   A CG1 1 ? 
ATOM   2173 C CG2 . ILE   A 1 281 ? -8.248  -9.969  31.645  1.000 51.159  0 281 ILE   A CG2 1 ? 
ATOM   2174 C CD1 . ILE   A 1 281 ? -9.464  -7.231  30.720  1.000 47.925  0 281 ILE   A CD1 1 ? 
ATOM   2175 N N   . LEU   A 1 282 ? -5.218  -11.407 31.129  1.000 52.422  0 282 LEU   A N   1 ? 
ATOM   2176 C CA  . LEU   A 1 282 ? -4.782  -12.762 30.845  1.000 50.645  0 282 LEU   A CA  1 ? 
ATOM   2177 C C   . LEU   A 1 282 ? -3.987  -12.749 29.540  1.000 44.871  0 282 LEU   A C   1 ? 
ATOM   2178 O O   . LEU   A 1 282 ? -4.120  -13.634 28.701  1.000 42.621  0 282 LEU   A O   1 ? 
ATOM   2179 C CB  . LEU   A 1 282 ? -6.008  -13.687 30.788  1.000 52.108  0 282 LEU   A CB  1 ? 
ATOM   2180 C CG  . LEU   A 1 282 ? -6.805  -13.816 32.089  1.000 51.999  0 282 LEU   A CG  1 ? 
ATOM   2181 C CD1 . LEU   A 1 282 ? -8.042  -14.681 31.910  1.000 52.694  0 282 LEU   A CD1 1 ? 
ATOM   2182 C CD2 . LEU   A 1 282 ? -5.953  -14.389 33.204  1.000 53.362  0 282 LEU   A CD2 1 ? 
ATOM   2183 N N   . GLY   A 1 283 ? -3.171  -11.705 29.380  1.000 47.228  0 283 GLY   A N   1 ? 
ATOM   2184 C CA  . GLY   A 1 283 ? -2.231  -11.607 28.276  1.000 52.757  0 283 GLY   A CA  1 ? 
ATOM   2185 C C   . GLY   A 1 283 ? -2.869  -11.210 26.943  1.000 54.539  0 283 GLY   A C   1 ? 
ATOM   2186 O O   . GLY   A 1 283 ? -2.156  -10.989 25.962  1.000 55.132  0 283 GLY   A O   1 ? 
ATOM   2187 N N   . SER   A 1 284 ? -4.205  -11.133 26.908  1.000 53.397  0 284 SER   A N   1 ? 
ATOM   2188 C CA  . SER   A 1 284 ? -4.923  -10.850 25.680  1.000 50.826  0 284 SER   A CA  1 ? 
ATOM   2189 C C   . SER   A 1 284 ? -5.272  -9.367  25.634  1.000 53.470  0 284 SER   A C   1 ? 
ATOM   2190 O O   . SER   A 1 284 ? -5.851  -8.845  26.584  1.000 51.536  0 284 SER   A O   1 ? 
ATOM   2191 C CB  . SER   A 1 284 ? -6.144  -11.705 25.568  1.000 48.204  0 284 SER   A CB  1 ? 
ATOM   2192 O OG  . SER   A 1 284 ? -7.065  -11.125 24.660  1.000 49.634  0 284 SER   A OG  1 ? 
ATOM   2193 N N   . ALA   A 1 285 ? -4.927  -8.712  24.514  1.000 55.965  0 285 ALA   A N   1 ? 
ATOM   2194 C CA  . ALA   A 1 285 ? -5.094  -7.273  24.366  1.000 51.107  0 285 ALA   A CA  1 ? 
ATOM   2195 C C   . ALA   A 1 285 ? -6.507  -6.940  23.881  1.000 51.817  0 285 ALA   A C   1 ? 
ATOM   2196 O O   . ALA   A 1 285 ? -6.852  -5.769  23.742  1.000 51.091  0 285 ALA   A O   1 ? 
ATOM   2197 C CB  . ALA   A 1 285 ? -4.034  -6.732  23.442  1.000 48.933  0 285 ALA   A CB  1 ? 
ATOM   2198 N N   . LEU   A 1 286 ? -7.326  -7.973  23.639  1.000 52.439  0 286 LEU   A N   1 ? 
ATOM   2199 C CA  . LEU   A 1 286 ? -8.750  -7.793  23.396  1.000 55.192  0 286 LEU   A CA  1 ? 
ATOM   2200 C C   . LEU   A 1 286 ? -9.545  -8.677  24.356  1.000 50.169  0 286 LEU   A C   1 ? 
ATOM   2201 O O   . LEU   A 1 286 ? -8.976  -9.370  25.209  1.000 41.393  0 286 LEU   A O   1 ? 
ATOM   2202 C CB  . LEU   A 1 286 ? -9.049  -8.134  21.930  1.000 66.424  0 286 LEU   A CB  1 ? 
ATOM   2203 C CG  . LEU   A 1 286 ? -8.998  -9.618  21.558  1.000 76.779  0 286 LEU   A CG  1 ? 
ATOM   2204 C CD1 . LEU   A 1 286 ? -10.211 -10.015 20.723  1.000 80.066  0 286 LEU   A CD1 1 ? 
ATOM   2205 C CD2 . LEU   A 1 286 ? -7.694  -9.963  20.843  1.000 80.829  0 286 LEU   A CD2 1 ? 
ATOM   2206 N N   . LEU   A 1 287 ? -10.872 -8.618  24.201  1.000 44.365  0 287 LEU   A N   1 ? 
ATOM   2207 C CA  . LEU   A 1 287 ? -11.782 -9.441  24.972  1.000 42.184  0 287 LEU   A CA  1 ? 
ATOM   2208 C C   . LEU   A 1 287 ? -11.969 -10.770 24.251  1.000 41.382  0 287 LEU   A C   1 ? 
ATOM   2209 O O   . LEU   A 1 287 ? -12.076 -10.789 23.034  1.000 47.036  0 287 LEU   A O   1 ? 
ATOM   2210 C CB  . LEU   A 1 287 ? -13.100 -8.682  25.126  1.000 41.829  0 287 LEU   A CB  1 ? 
ATOM   2211 C CG  . LEU   A 1 287 ? -12.965 -7.302  25.764  1.000 42.672  0 287 LEU   A CG  1 ? 
ATOM   2212 C CD1 . LEU   A 1 287 ? -14.316 -6.625  25.911  1.000 40.349  0 287 LEU   A CD1 1 ? 
ATOM   2213 C CD2 . LEU   A 1 287 ? -12.263 -7.391  27.109  1.000 42.502  0 287 LEU   A CD2 1 ? 
ATOM   2214 N N   . GLU   A 1 288 ? -11.971 -11.864 25.019  1.000 41.391  0 288 GLU   A N   1 ? 
ATOM   2215 C CA  . GLU   A 1 288 ? -12.005 -13.218 24.496  1.000 40.818  0 288 GLU   A CA  1 ? 
ATOM   2216 C C   . GLU   A 1 288 ? -13.355 -13.834 24.818  1.000 41.014  0 288 GLU   A C   1 ? 
ATOM   2217 O O   . GLU   A 1 288 ? -13.716 -13.964 25.982  1.000 46.869  0 288 GLU   A O   1 ? 
ATOM   2218 C CB  . GLU   A 1 288 ? -10.932 -14.077 25.153  1.000 44.807  0 288 GLU   A CB  1 ? 
ATOM   2219 C CG  . GLU   A 1 288 ? -9.527  -13.550 24.959  1.000 50.352  0 288 GLU   A CG  1 ? 
ATOM   2220 C CD  . GLU   A 1 288 ? -8.933  -13.827 23.591  1.000 59.432  0 288 GLU   A CD  1 ? 
ATOM   2221 O OE1 . GLU   A 1 288 ? -7.725  -13.541 23.419  1.000 64.116  0 288 GLU   A OE1 1 ? 
ATOM   2222 O OE2 . GLU   A 1 288 ? -9.674  -14.338 22.707  1.000 67.131  0 288 GLU   A OE2 1 ? 
ATOM   2223 N N   . ASP   A 1 289 ? -14.082 -14.223 23.777  1.000 44.278  0 289 ASP   A N   1 ? 
ATOM   2224 C CA  . ASP   A 1 289 ? -15.449 -14.675 23.928  1.000 46.713  0 289 ASP   A CA  1 ? 
ATOM   2225 C C   . ASP   A 1 289 ? -15.568 -16.143 23.535  1.000 48.445  0 289 ASP   A C   1 ? 
ATOM   2226 O O   . ASP   A 1 289 ? -16.680 -16.623 23.309  1.000 49.395  0 289 ASP   A O   1 ? 
ATOM   2227 C CB  . ASP   A 1 289 ? -16.372 -13.837 23.056  1.000 46.424  0 289 ASP   A CB  1 ? 
ATOM   2228 C CG  . ASP   A 1 289 ? -16.170 -14.111 21.582  1.000 51.131  0 289 ASP   A CG  1 ? 
ATOM   2229 O OD1 . ASP   A 1 289 ? -14.998 -14.168 21.138  1.000 54.032  0 289 ASP   A OD1 1 ? 
ATOM   2230 O OD2 . ASP   A 1 289 ? -17.186 -14.264 20.895  1.000 58.533  0 289 ASP   A OD2 1 ? 
ATOM   2231 N N   . GLU   A 1 290 ? -14.426 -16.841 23.452  1.000 52.021  0 290 GLU   A N   1 ? 
ATOM   2232 C CA  . GLU   A 1 290 ? -14.415 -18.256 23.097  1.000 60.039  0 290 GLU   A CA  1 ? 
ATOM   2233 C C   . GLU   A 1 290 ? -14.003 -19.079 24.321  1.000 56.501  0 290 GLU   A C   1 ? 
ATOM   2234 O O   . GLU   A 1 290 ? -13.108 -19.918 24.242  1.000 59.792  0 290 GLU   A O   1 ? 
ATOM   2235 C CB  . GLU   A 1 290 ? -13.519 -18.511 21.874  1.000 64.630  0 290 GLU   A CB  1 ? 
ATOM   2236 C CG  . GLU   A 1 290 ? -14.201 -18.323 20.515  1.000 69.107  0 290 GLU   A CG  1 ? 
ATOM   2237 C CD  . GLU   A 1 290 ? -13.607 -19.105 19.347  1.000 74.807  0 290 GLU   A CD  1 ? 
ATOM   2238 O OE1 . GLU   A 1 290 ? -12.593 -19.820 19.562  1.000 73.709  0 290 GLU   A OE1 1 ? 
ATOM   2239 O OE2 . GLU   A 1 290 ? -14.163 -19.017 18.212  1.000 79.545  0 290 GLU   A OE2 1 ? 
ATOM   2240 N N   . PHE   A 1 291 ? -14.669 -18.806 25.451  1.000 51.148  0 291 PHE   A N   1 ? 
ATOM   2241 C CA  . PHE   A 1 291 ? -14.581 -19.591 26.671  1.000 46.513  0 291 PHE   A CA  1 ? 
ATOM   2242 C C   . PHE   A 1 291 ? -15.972 -19.666 27.296  1.000 45.704  0 291 PHE   A C   1 ? 
ATOM   2243 O O   . PHE   A 1 291 ? -16.550 -18.631 27.613  1.000 47.867  0 291 PHE   A O   1 ? 
ATOM   2244 C CB  . PHE   A 1 291 ? -13.621 -18.949 27.676  1.000 43.624  0 291 PHE   A CB  1 ? 
ATOM   2245 C CG  . PHE   A 1 291 ? -12.150 -19.116 27.399  1.000 40.208  0 291 PHE   A CG  1 ? 
ATOM   2246 C CD1 . PHE   A 1 291 ? -11.479 -20.266 27.789  1.000 41.235  0 291 PHE   A CD1 1 ? 
ATOM   2247 C CD2 . PHE   A 1 291 ? -11.426 -18.110 26.784  1.000 40.172  0 291 PHE   A CD2 1 ? 
ATOM   2248 C CE1 . PHE   A 1 291 ? -10.120 -20.414 27.553  1.000 40.709  0 291 PHE   A CE1 1 ? 
ATOM   2249 C CE2 . PHE   A 1 291 ? -10.067 -18.259 26.548  1.000 41.357  0 291 PHE   A CE2 1 ? 
ATOM   2250 C CZ  . PHE   A 1 291 ? -9.415  -19.409 26.933  1.000 40.499  0 291 PHE   A CZ  1 ? 
ATOM   2251 N N   . THR   A 1 292 ? -16.516 -20.878 27.454  1.000 44.744  0 292 THR   A N   1 ? 
ATOM   2252 C CA  . THR   A 1 292 ? -17.783 -21.043 28.145  1.000 46.209  0 292 THR   A CA  1 ? 
ATOM   2253 C C   . THR   A 1 292 ? -17.560 -20.922 29.650  1.000 48.127  0 292 THR   A C   1 ? 
ATOM   2254 O O   . THR   A 1 292 ? -16.472 -21.184 30.169  1.000 47.192  0 292 THR   A O   1 ? 
ATOM   2255 C CB  . THR   A 1 292 ? -18.467 -22.392 27.867  1.000 44.346  0 292 THR   A CB  1 ? 
ATOM   2256 O OG1 . THR   A 1 292 ? -17.481 -23.423 27.893  1.000 42.541  0 292 THR   A OG1 1 ? 
ATOM   2257 C CG2 . THR   A 1 292 ? -19.206 -22.433 26.551  1.000 42.858  0 292 THR   A CG2 1 ? 
ATOM   2258 N N   . PRO   A 1 293 ? -18.607 -20.535 30.403  1.000 46.516  0 293 PRO   A N   1 ? 
ATOM   2259 C CA  . PRO   A 1 293 ? -18.595 -20.695 31.856  1.000 45.862  0 293 PRO   A CA  1 ? 
ATOM   2260 C C   . PRO   A 1 293 ? -17.961 -22.027 32.242  1.000 46.740  0 293 PRO   A C   1 ? 
ATOM   2261 O O   . PRO   A 1 293 ? -17.031 -22.067 33.045  1.000 45.329  0 293 PRO   A O   1 ? 
ATOM   2262 C CB  . PRO   A 1 293 ? -20.096 -20.637 32.173  1.000 45.131  0 293 PRO   A CB  1 ? 
ATOM   2263 C CG  . PRO   A 1 293 ? -20.634 -19.652 31.156  1.000 44.194  0 293 PRO   A CG  1 ? 
ATOM   2264 C CD  . PRO   A 1 293 ? -19.850 -19.939 29.895  1.000 43.253  0 293 PRO   A CD  1 ? 
ATOM   2265 N N   . PHE   A 1 294 ? -18.446 -23.099 31.601  1.000 48.982  0 294 PHE   A N   1 ? 
ATOM   2266 C CA  . PHE   A 1 294 ? -18.032 -24.457 31.916  1.000 49.910  0 294 PHE   A CA  1 ? 
ATOM   2267 C C   . PHE   A 1 294 ? -16.544 -24.614 31.631  1.000 47.413  0 294 PHE   A C   1 ? 
ATOM   2268 O O   . PHE   A 1 294 ? -15.807 -25.172 32.436  1.000 51.293  0 294 PHE   A O   1 ? 
ATOM   2269 C CB  . PHE   A 1 294 ? -18.859 -25.460 31.119  1.000 51.339  0 294 PHE   A CB  1 ? 
ATOM   2270 C CG  . PHE   A 1 294 ? -20.333 -25.157 31.117  1.000 63.104  0 294 PHE   A CG  1 ? 
ATOM   2271 C CD1 . PHE   A 1 294 ? -21.140 -25.528 32.185  1.000 70.294  0 294 PHE   A CD1 1 ? 
ATOM   2272 C CD2 . PHE   A 1 294 ? -20.903 -24.450 30.067  1.000 71.644  0 294 PHE   A CD2 1 ? 
ATOM   2273 C CE1 . PHE   A 1 294 ? -22.497 -25.235 32.180  1.000 75.169  0 294 PHE   A CE1 1 ? 
ATOM   2274 C CE2 . PHE   A 1 294 ? -22.258 -24.154 30.062  1.000 74.736  0 294 PHE   A CE2 1 ? 
ATOM   2275 C CZ  . PHE   A 1 294 ? -23.052 -24.546 31.119  1.000 78.826  0 294 PHE   A CZ  1 ? 
ATOM   2276 N N   . ASP   A 1 295 ? -16.095 -24.081 30.498  1.000 42.713  0 295 ASP   A N   1 ? 
ATOM   2277 C CA  . ASP   A 1 295 ? -14.686 -24.155 30.168  1.000 46.217  0 295 ASP   A CA  1 ? 
ATOM   2278 C C   . ASP   A 1 295 ? -13.852 -23.628 31.321  1.000 43.606  0 295 ASP   A C   1 ? 
ATOM   2279 O O   . ASP   A 1 295 ? -12.822 -24.194 31.657  1.000 43.753  0 295 ASP   A O   1 ? 
ATOM   2280 C CB  . ASP   A 1 295 ? -14.360 -23.362 28.904  1.000 51.448  0 295 ASP   A CB  1 ? 
ATOM   2281 C CG  . ASP   A 1 295 ? -14.739 -24.099 27.634  1.000 54.671  0 295 ASP   A CG  1 ? 
ATOM   2282 O OD1 . ASP   A 1 295 ? -14.918 -25.338 27.702  1.000 58.202  0 295 ASP   A OD1 1 ? 
ATOM   2283 O OD2 . ASP   A 1 295 ? -14.865 -23.431 26.597  1.000 57.263  0 295 ASP   A OD2 1 ? 
ATOM   2284 N N   . VAL   A 1 296 ? -14.308 -22.519 31.894  1.000 47.966  0 296 VAL   A N   1 ? 
ATOM   2285 C CA  . VAL   A 1 296 ? -13.566 -21.822 32.926  1.000 49.620  0 296 VAL   A CA  1 ? 
ATOM   2286 C C   . VAL   A 1 296 ? -13.571 -22.681 34.189  1.000 48.482  0 296 VAL   A C   1 ? 
ATOM   2287 O O   . VAL   A 1 296 ? -12.526 -22.940 34.790  1.000 46.017  0 296 VAL   A O   1 ? 
ATOM   2288 C CB  . VAL   A 1 296 ? -14.171 -20.419 33.146  1.000 51.933  0 296 VAL   A CB  1 ? 
ATOM   2289 C CG1 . VAL   A 1 296 ? -13.637 -19.749 34.399  1.000 52.542  0 296 VAL   A CG1 1 ? 
ATOM   2290 C CG2 . VAL   A 1 296 ? -13.965 -19.519 31.932  1.000 50.404  0 296 VAL   A CG2 1 ? 
ATOM   2291 N N   . VAL   A 1 297 ? -14.765 -23.137 34.572  1.000 49.402  0 297 VAL   A N   1 ? 
ATOM   2292 C CA  . VAL   A 1 297 ? -14.902 -24.076 35.673  1.000 50.941  0 297 VAL   A CA  1 ? 
ATOM   2293 C C   . VAL   A 1 297 ? -13.830 -25.155 35.531  1.000 51.401  0 297 VAL   A C   1 ? 
ATOM   2294 O O   . VAL   A 1 297 ? -12.950 -25.257 36.384  1.000 47.442  0 297 VAL   A O   1 ? 
ATOM   2295 C CB  . VAL   A 1 297 ? -16.323 -24.674 35.719  1.000 49.398  0 297 VAL   A CB  1 ? 
ATOM   2296 C CG1 . VAL   A 1 297 ? -16.414 -25.910 36.604  1.000 47.154  0 297 VAL   A CG1 1 ? 
ATOM   2297 C CG2 . VAL   A 1 297 ? -17.342 -23.629 36.146  1.000 48.457  0 297 VAL   A CG2 1 ? 
ATOM   2298 N N   . ARG   A 1 298 ? -13.902 -25.916 34.427  1.000 51.116  0 298 ARG   A N   1 ? 
ATOM   2299 C CA  . ARG   A 1 298 ? -12.986 -27.015 34.179  1.000 52.499  0 298 ARG   A CA  1 ? 
ATOM   2300 C C   . ARG   A 1 298 ? -11.561 -26.588 34.493  1.000 50.178  0 298 ARG   A C   1 ? 
ATOM   2301 O O   . ARG   A 1 298 ? -10.838 -27.294 35.177  1.000 57.254  0 298 ARG   A O   1 ? 
ATOM   2302 C CB  . ARG   A 1 298 ? -13.003 -27.488 32.723  1.000 61.411  0 298 ARG   A CB  1 ? 
ATOM   2303 C CG  . ARG   A 1 298 ? -14.358 -27.976 32.229  1.000 74.813  0 298 ARG   A CG  1 ? 
ATOM   2304 C CD  . ARG   A 1 298 ? -14.272 -28.869 30.996  1.000 79.534  0 298 ARG   A CD  1 ? 
ATOM   2305 N NE  . ARG   A 1 298 ? -15.343 -28.657 30.020  1.000 83.539  0 298 ARG   A NE  1 ? 
ATOM   2306 C CZ  . ARG   A 1 298 ? -16.654 -28.705 30.269  1.000 82.706  0 298 ARG   A CZ  1 ? 
ATOM   2307 N NH1 . ARG   A 1 298 ? -17.520 -28.534 29.284  1.000 81.415  0 298 ARG   A NH1 1 ? 
ATOM   2308 N NH2 . ARG   A 1 298 ? -17.109 -28.922 31.492  1.000 80.097  0 298 ARG   A NH2 1 ? 
ATOM   2309 N N   . GLN   A 1 299 ? -11.148 -25.436 33.979  1.000 47.866  0 299 GLN   A N   1 ? 
ATOM   2310 C CA  . GLN   A 1 299 ? -9.737  -25.119 33.979  1.000 48.612  0 299 GLN   A CA  1 ? 
ATOM   2311 C C   . GLN   A 1 299 ? -9.328  -24.534 35.323  1.000 52.773  0 299 GLN   A C   1 ? 
ATOM   2312 O O   . GLN   A 1 299 ? -8.142  -24.513 35.632  1.000 58.245  0 299 GLN   A O   1 ? 
ATOM   2313 C CB  . GLN   A 1 299 ? -9.398  -24.177 32.827  1.000 46.792  0 299 GLN   A CB  1 ? 
ATOM   2314 C CG  . GLN   A 1 299 ? -7.942  -23.733 32.872  1.000 46.833  0 299 GLN   A CG  1 ? 
ATOM   2315 C CD  . GLN   A 1 299 ? -7.442  -23.073 31.614  1.000 45.240  0 299 GLN   A CD  1 ? 
ATOM   2316 O OE1 . GLN   A 1 299 ? -6.312  -22.592 31.581  1.000 44.225  0 299 GLN   A OE1 1 ? 
ATOM   2317 N NE2 . GLN   A 1 299 ? -8.270  -23.039 30.580  1.000 43.443  0 299 GLN   A NE2 1 ? 
ATOM   2318 N N   . CYS   A 1 300 ? -10.306 -24.052 36.098  1.000 59.529  0 300 CYS   A N   1 ? 
ATOM   2319 C CA  . CYS   A 1 300 ? -10.054 -23.530 37.433  1.000 64.795  0 300 CYS   A CA  1 ? 
ATOM   2320 C C   . CYS   A 1 300 ? -10.599 -24.504 38.478  1.000 69.868  0 300 CYS   A C   1 ? 
ATOM   2321 O O   . CYS   A 1 300 ? -11.198 -24.093 39.470  1.000 73.588  0 300 CYS   A O   1 ? 
ATOM   2322 C CB  . CYS   A 1 300 ? -10.691 -22.153 37.589  1.000 67.125  0 300 CYS   A CB  1 ? 
ATOM   2323 S SG  . CYS   A 1 300 ? -10.170 -20.956 36.327  1.000 68.857  0 300 CYS   A SG  1 ? 
ATOM   2324 N N   . SER   A 1 301 ? -10.401 -25.802 38.213  1.000 70.069  0 301 SER   A N   1 ? 
ATOM   2325 C CA  . SER   A 1 301 ? -10.912 -26.895 39.031  1.000 70.297  0 301 SER   A CA  1 ? 
ATOM   2326 C C   . SER   A 1 301 ? -10.196 -28.208 38.687  1.000 80.859  0 301 SER   A C   1 ? 
ATOM   2327 O O   . SER   A 1 301 ? -10.103 -29.107 39.526  1.000 78.545  0 301 SER   A O   1 ? 
ATOM   2328 C CB  . SER   A 1 301 ? -12.407 -27.025 38.877  1.000 67.156  0 301 SER   A CB  1 ? 
ATOM   2329 O OG  . SER   A 1 301 ? -12.842 -28.339 39.205  1.000 68.756  0 301 SER   A OG  1 ? 
ATOM   2330 N N   . GLY   A 1 302 ? -9.749  -28.335 37.426  1.000 90.978  0 302 GLY   A N   1 ? 
ATOM   2331 C CA  . GLY   A 1 302 ? -8.763  -29.324 37.011  1.000 87.807  0 302 GLY   A CA  1 ? 
ATOM   2332 C C   . GLY   A 1 302 ? -9.386  -30.670 36.650  1.000 88.126  0 302 GLY   A C   1 ? 
ATOM   2333 O O   . GLY   A 1 302 ? -8.781  -31.707 36.907  1.000 85.109  0 302 GLY   A O   1 ? 
ATOM   2334 N N   . VAL   A 1 303 ? -10.569 -30.631 36.016  1.000 93.699  0 303 VAL   A N   1 ? 
ATOM   2335 C CA  . VAL   A 1 303 ? -11.360 -31.826 35.748  1.000 96.094  0 303 VAL   A CA  1 ? 
ATOM   2336 C C   . VAL   A 1 303 ? -10.597 -32.683 34.743  1.000 99.312  0 303 VAL   A C   1 ? 
ATOM   2337 O O   . VAL   A 1 303 ? -9.773  -32.159 34.001  1.000 102.883 0 303 VAL   A O   1 ? 
ATOM   2338 C CB  . VAL   A 1 303 ? -12.778 -31.509 35.221  1.000 92.195  0 303 VAL   A CB  1 ? 
ATOM   2339 C CG1 . VAL   A 1 303 ? -13.465 -30.410 36.020  1.000 90.081  0 303 VAL   A CG1 1 ? 
ATOM   2340 C CG2 . VAL   A 1 303 ? -12.776 -31.160 33.739  1.000 97.731  0 303 VAL   A CG2 1 ? 
ATOM   2341 N N   . THR   A 1 304 ? -10.908 -33.985 34.713  1.000 100.446 0 304 THR   A N   1 ? 
ATOM   2342 C CA  . THR   A 1 304 ? -10.227 -34.931 33.841  1.000 100.020 0 304 THR   A CA  1 ? 
ATOM   2343 C C   . THR   A 1 304 ? -11.257 -35.901 33.244  1.000 102.513 0 304 THR   A C   1 ? 
ATOM   2344 O O   . THR   A 1 304 ? -12.440 -35.845 33.595  1.000 90.198  0 304 THR   A O   1 ? 
ATOM   2345 C CB  . THR   A 1 304 ? -9.054  -35.574 34.598  1.000 95.181  0 304 THR   A CB  1 ? 
ATOM   2346 O OG1 . THR   A 1 304 ? -8.344  -36.377 33.658  1.000 99.135  0 304 THR   A OG1 1 ? 
ATOM   2347 C CG2 . THR   A 1 304 ? -9.481  -36.391 35.800  1.000 88.516  0 304 THR   A CG2 1 ? 
ATOM   2348 N N   . PHE   A 1 305 ? -10.802 -36.770 32.321  1.000 104.519 0 305 PHE   A N   1 ? 
ATOM   2349 C CA  . PHE   A 1 305 ? -11.696 -37.526 31.448  1.000 98.162  0 305 PHE   A CA  1 ? 
ATOM   2350 C C   . PHE   A 1 305 ? -11.328 -39.021 31.430  1.000 90.339  0 305 PHE   A C   1 ? 
ATOM   2351 O O   . PHE   A 1 305 ? -10.162 -39.395 31.678  1.000 84.365  0 305 PHE   A O   1 ? 
ATOM   2352 C CB  . PHE   A 1 305 ? -11.705 -36.909 30.039  1.000 94.187  0 305 PHE   A CB  1 ? 
ATOM   2353 C CG  . PHE   A 1 305 ? -12.067 -35.443 30.006  1.000 91.960  0 305 PHE   A CG  1 ? 
ATOM   2354 C CD1 . PHE   A 1 305 ? -11.082 -34.470 29.937  1.000 88.488  0 305 PHE   A CD1 1 ? 
ATOM   2355 C CD2 . PHE   A 1 305 ? -13.392 -35.029 30.061  1.000 86.813  0 305 PHE   A CD2 1 ? 
ATOM   2356 C CE1 . PHE   A 1 305 ? -11.419 -33.125 29.938  1.000 89.868  0 305 PHE   A CE1 1 ? 
ATOM   2357 C CE2 . PHE   A 1 305 ? -13.726 -33.683 30.050  1.000 82.194  0 305 PHE   A CE2 1 ? 
ATOM   2358 C CZ  . PHE   A 1 305 ? -12.736 -32.734 29.996  1.000 87.884  0 305 PHE   A CZ  1 ? 
HETATM 2359 N N1  . A1H9Y B 2 .   ? -15.380 -25.936 -1.001  1.000 46.063  0 401 A1H9Y A N1  1 ? 
HETATM 2360 N N3  . A1H9Y B 2 .   ? -13.543 -27.536 1.628   1.000 46.033  0 401 A1H9Y A N3  1 ? 
HETATM 2361 C C4  . A1H9Y B 2 .   ? -15.614 -24.640 -0.560  1.000 53.020  0 401 A1H9Y A C4  1 ? 
HETATM 2362 C C5  . A1H9Y B 2 .   ? -15.294 -26.243 -2.334  1.000 49.830  0 401 A1H9Y A C5  1 ? 
HETATM 2363 C C6  . A1H9Y B 2 .   ? -15.248 -26.999 0.003   1.000 42.332  0 401 A1H9Y A C6  1 ? 
HETATM 2364 C C7  . A1H9Y B 2 .   ? -13.793 -27.327 0.325   1.000 42.196  0 401 A1H9Y A C7  1 ? 
HETATM 2365 C C8  . A1H9Y B 2 .   ? -12.484 -28.344 2.240   1.000 47.585  0 401 A1H9Y A C8  1 ? 
HETATM 2366 C C10 . A1H9Y B 2 .   ? -17.545 -27.957 -0.153  1.000 41.809  0 401 A1H9Y A C10 1 ? 
HETATM 2367 C C13 . A1H9Y B 2 .   ? -12.695 -29.824 1.825   1.000 48.430  0 401 A1H9Y A C13 1 ? 
HETATM 2368 C C15 . A1H9Y B 2 .   ? -11.425 -30.674 1.715   1.000 45.239  0 401 A1H9Y A C15 1 ? 
HETATM 2369 C C17 . A1H9Y B 2 .   ? -9.775  -25.594 1.536   1.000 46.799  0 401 A1H9Y A C17 1 ? 
HETATM 2370 C C20 . A1H9Y B 2 .   ? -16.620 -21.307 -1.697  1.000 67.311  0 401 A1H9Y A C20 1 ? 
HETATM 2371 C C21 . A1H9Y B 2 .   ? -16.592 -19.979 -0.964  1.000 70.413  0 401 A1H9Y A C21 1 ? 
HETATM 2372 C C22 . A1H9Y B 2 .   ? -17.942 -19.700 -0.312  1.000 67.592  0 401 A1H9Y A C22 1 ? 
HETATM 2373 C C24 . A1H9Y B 2 .   ? -10.331 -32.457 0.439   1.000 46.519  0 401 A1H9Y A C24 1 ? 
HETATM 2374 C C1  . A1H9Y B 2 .   ? -15.443 -25.298 -3.282  1.000 52.464  0 401 A1H9Y A C1  1 ? 
HETATM 2375 C C2  . A1H9Y B 2 .   ? -15.681 -23.970 -2.912  1.000 53.914  0 401 A1H9Y A C2  1 ? 
HETATM 2376 C C3  . A1H9Y B 2 .   ? -15.794 -23.639 -1.592  1.000 58.427  0 401 A1H9Y A C3  1 ? 
HETATM 2377 N N2  . A1H9Y B 2 .   ? -16.026 -22.357 -1.064  1.000 63.441  0 401 A1H9Y A N2  1 ? 
HETATM 2378 C C9  . A1H9Y B 2 .   ? -16.081 -28.225 -0.377  1.000 40.690  0 401 A1H9Y A C9  1 ? 
HETATM 2379 C C11 . A1H9Y B 2 .   ? -18.343 -27.180 -1.154  1.000 41.500  0 401 A1H9Y A C11 1 ? 
HETATM 2380 C C12 . A1H9Y B 2 .   ? -18.593 -28.641 -0.977  1.000 41.470  0 401 A1H9Y A C12 1 ? 
HETATM 2381 O O1  . A1H9Y B 2 .   ? -12.992 -27.520 -0.575  1.000 43.969  0 401 A1H9Y A O1  1 ? 
HETATM 2382 O O2  . A1H9Y B 2 .   ? -15.696 -24.405 0.643   1.000 55.166  0 401 A1H9Y A O2  1 ? 
HETATM 2383 C C14 . A1H9Y B 2 .   ? -11.107 -27.730 1.962   1.000 48.156  0 401 A1H9Y A C14 1 ? 
HETATM 2384 C C16 . A1H9Y B 2 .   ? -11.018 -26.220 2.174   1.000 45.424  0 401 A1H9Y A C16 1 ? 
HETATM 2385 C C18 . A1H9Y B 2 .   ? -9.178  -24.695 2.612   1.000 45.381  0 401 A1H9Y A C18 1 ? 
HETATM 2386 N N4  . A1H9Y B 2 .   ? -9.900  -25.047 3.824   1.000 44.572  0 401 A1H9Y A N4  1 ? 
HETATM 2387 C C19 . A1H9Y B 2 .   ? -10.987 -25.774 3.627   1.000 42.970  0 401 A1H9Y A C19 1 ? 
HETATM 2388 O O3  . A1H9Y B 2 .   ? -11.855 -25.999 4.464   1.000 42.224  0 401 A1H9Y A O3  1 ? 
HETATM 2389 C C23 . A1H9Y B 2 .   ? -16.197 -18.860 -1.923  1.000 73.222  0 401 A1H9Y A C23 1 ? 
HETATM 2390 N N5  . A1H9Y B 2 .   ? -11.420 -31.541 0.711   1.000 46.897  0 401 A1H9Y A N5  1 ? 
HETATM 2391 O O4  . A1H9Y B 2 .   ? -17.135 -21.416 -2.813  1.000 74.873  0 401 A1H9Y A O4  1 ? 
HETATM 2392 O O5  . A1H9Y B 2 .   ? -10.523 -30.585 2.538   1.000 42.473  0 401 A1H9Y A O5  1 ? 
HETATM 2393 O O6  . A1H9Y B 2 .   ? -13.403 -29.913 0.598   1.000 44.906  0 401 A1H9Y A O6  1 ? 
HETATM 2394 O O   . HOH   C 3 .   ? -21.711 -19.776 26.003  1.000 25.513  0 501 HOH   A O   1 ? 
HETATM 2395 O O   . HOH   C 3 .   ? -14.603 -16.031 26.810  1.000 40.233  0 502 HOH   A O   1 ? 
HETATM 2396 O O   . HOH   C 3 .   ? -26.082 -28.045 1.247   1.000 30.193  0 503 HOH   A O   1 ? 
HETATM 2397 O O   . HOH   C 3 .   ? -24.988 -17.541 -3.948  1.000 26.472  0 504 HOH   A O   1 ? 
HETATM 2398 O O   . HOH   C 3 .   ? -5.340  -22.382 36.204  1.000 33.155  0 505 HOH   A O   1 ? 
HETATM 2399 O O   . HOH   C 3 .   ? -20.440 -31.768 1.553   1.000 29.866  0 506 HOH   A O   1 ? 
HETATM 2400 O O   . HOH   C 3 .   ? -2.537  -21.958 24.092  1.000 39.015  0 507 HOH   A O   1 ? 
HETATM 2401 O O   . HOH   C 3 .   ? -3.240  -13.511 34.047  1.000 43.391  0 508 HOH   A O   1 ? 
HETATM 2402 O O   . HOH   C 3 .   ? -8.997  -44.442 1.176   1.000 40.753  0 509 HOH   A O   1 ? 
HETATM 2403 O O   . HOH   C 3 .   ? -15.499 -43.430 26.419  1.000 35.850  0 510 HOH   A O   1 ? 
HETATM 2404 O O   . HOH   C 3 .   ? -20.381 -19.871 36.225  1.000 38.281  0 511 HOH   A O   1 ? 
HETATM 2405 O O   . HOH   C 3 .   ? -6.014  7.043   30.563  1.000 36.148  0 512 HOH   A O   1 ? 
HETATM 2406 O O   . HOH   C 3 .   ? -4.620  -43.486 8.751   1.000 31.116  0 513 HOH   A O   1 ? 
HETATM 2407 O O   . HOH   C 3 .   ? -24.391 -13.346 25.641  1.000 46.075  0 514 HOH   A O   1 ? 
HETATM 2408 O O   . HOH   C 3 .   ? -7.319  -29.984 40.467  1.000 33.004  0 515 HOH   A O   1 ? 
HETATM 2409 O O   . HOH   C 3 .   ? -28.867 -19.252 27.155  1.000 39.626  0 516 HOH   A O   1 ? 
HETATM 2410 O O   . HOH   C 3 .   ? -2.582  -16.462 31.664  1.000 26.315  0 517 HOH   A O   1 ? 
HETATM 2411 O O   . HOH   C 3 .   ? -11.734 -13.466 20.419  1.000 28.816  0 518 HOH   A O   1 ? 
HETATM 2412 O O   . HOH   C 3 .   ? -12.784 -27.767 27.876  1.000 32.152  0 519 HOH   A O   1 ? 
HETATM 2413 O O   . HOH   C 3 .   ? -10.136 -28.962 27.825  1.000 39.146  0 520 HOH   A O   1 ? 
HETATM 2414 O O   . HOH   C 3 .   ? -17.562 -57.083 -0.631  1.000 38.584  0 521 HOH   A O   1 ? 
HETATM 2415 O O   . HOH   C 3 .   ? -6.537  -45.914 12.736  1.000 30.262  0 522 HOH   A O   1 ? 
HETATM 2416 O O   . HOH   C 3 .   ? -29.551 -31.028 2.643   1.000 35.879  0 523 HOH   A O   1 ? 
HETATM 2417 O O   . HOH   C 3 .   ? -1.928  -36.430 -1.285  1.000 39.288  0 524 HOH   A O   1 ? 
# 
