data_9F35
# 
_entry.id   9F35 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9F35         pdb_00009f35 10.2210/pdb9f35/pdb 
WWPDB D_1292138060 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-05 ? 
2 'Structure model' 1 1 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9F35 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 p.cossar@tue.nl    Peter     Cossar ? 'principal investigator/group leader' 0000-0002-8260-5710 
3 l.brunsveld@tue.nl Brunsveld Luc    ? 'principal investigator/group leader' 0000-0001-5675-511X 
# 
_audit_author.name               'Wu, Q.' 
_audit_author.pdbx_ordinal       1 
_audit_author.identifier_ORCID   0000-0003-2494-3874 
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? UK ? ? primary 'Chem Sci'                 ?      ? 2041-6520 ? ? 16 ? 3523 3535 
'Proximity-enhanced cysteine-histidine crosslinking for elucidating intrinsically disordered and other protein complexes.' 2025 ? 
10.1039/d4sc07419j        39850253 ? ? 
? ? ? ? ? ? ? US ? ? 1       'Acta Crystallogr.,Sect.D' ABCRE6 ? 1399-0047 ? ? 68 ? 352  367  
'Towards automated crystallographic structure refinement with phenix.refine.'                                              2012 ? 
10.1107/S0907444912001308 22505256 ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wu, Q.'                     1  ? 
primary 'van den Wildenberg, S.A.H.' 2  ? 
primary 'Brzoskowski, J.C.R.'        3  ? 
primary 'van den Oetelaar, M.C.M.'   4  ? 
primary 'Verhoef, C.J.A.'            5  ? 
primary 'Genet, S.A.A.M.'            6  ? 
primary 'Ottmann, C.'                7  ? 
primary 'Markvoort, A.J.'            8  ? 
primary 'Brunsveld, L.'              9  ? 
primary 'Cossar, P.J.'               10 ? 
1       'Afonine, P.V.'              11 ? 
1       'Grosse-Kunstleve, R.W.'     12 ? 
1       'Echols, N.'                 13 ? 
1       'Headd, J.J.'                14 ? 
1       'Moriarty, N.W.'             15 ? 
1       'Mustyakimov, M.'            16 ? 
1       'Terwilliger, T.C.'          17 ? 
1       'Urzhumtsev, A.'             18 ? 
1       'Zwart, P.H.'                19 ? 
1       'Adams, P.D.'                20 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man '14-3-3 protein sigma'                  26558.914 1   ?        ? ? ? 
2 polymer syn 'Serine/threonine-protein kinase B-raf' 1308.276  1   2.7.11.1 ? ? ? 
3 water   nat water                                   18.015    203 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Epithelial cell marker protein 1,Stratifin' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no yes 
;GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELS(CSO)EERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNE
EGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAY
QEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
;
;GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSE
EKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAM
DISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
;
A ? 
2 'polypeptide(L)' no yes 'RDRSS(SEP)APNVH' RDRSSSAPNVH B ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   ALA n 
1 3   MET n 
1 4   GLY n 
1 5   SER n 
1 6   MET n 
1 7   GLU n 
1 8   ARG n 
1 9   ALA n 
1 10  SER n 
1 11  LEU n 
1 12  ILE n 
1 13  GLN n 
1 14  LYS n 
1 15  ALA n 
1 16  LYS n 
1 17  LEU n 
1 18  ALA n 
1 19  GLU n 
1 20  GLN n 
1 21  ALA n 
1 22  GLU n 
1 23  ARG n 
1 24  TYR n 
1 25  GLU n 
1 26  ASP n 
1 27  MET n 
1 28  ALA n 
1 29  ALA n 
1 30  PHE n 
1 31  MET n 
1 32  LYS n 
1 33  GLY n 
1 34  ALA n 
1 35  VAL n 
1 36  GLU n 
1 37  LYS n 
1 38  GLY n 
1 39  GLU n 
1 40  GLU n 
1 41  LEU n 
1 42  SER n 
1 43  CSO n 
1 44  GLU n 
1 45  GLU n 
1 46  ARG n 
1 47  ASN n 
1 48  LEU n 
1 49  LEU n 
1 50  SER n 
1 51  VAL n 
1 52  ALA n 
1 53  TYR n 
1 54  LYS n 
1 55  ASN n 
1 56  VAL n 
1 57  VAL n 
1 58  GLY n 
1 59  GLY n 
1 60  GLN n 
1 61  ARG n 
1 62  ALA n 
1 63  ALA n 
1 64  TRP n 
1 65  ARG n 
1 66  VAL n 
1 67  LEU n 
1 68  SER n 
1 69  SER n 
1 70  ILE n 
1 71  GLU n 
1 72  GLN n 
1 73  LYS n 
1 74  SER n 
1 75  ASN n 
1 76  GLU n 
1 77  GLU n 
1 78  GLY n 
1 79  SER n 
1 80  GLU n 
1 81  GLU n 
1 82  LYS n 
1 83  GLY n 
1 84  PRO n 
1 85  GLU n 
1 86  VAL n 
1 87  ARG n 
1 88  GLU n 
1 89  TYR n 
1 90  ARG n 
1 91  GLU n 
1 92  LYS n 
1 93  VAL n 
1 94  GLU n 
1 95  THR n 
1 96  GLU n 
1 97  LEU n 
1 98  GLN n 
1 99  GLY n 
1 100 VAL n 
1 101 CYS n 
1 102 ASP n 
1 103 THR n 
1 104 VAL n 
1 105 LEU n 
1 106 GLY n 
1 107 LEU n 
1 108 LEU n 
1 109 ASP n 
1 110 SER n 
1 111 HIS n 
1 112 LEU n 
1 113 ILE n 
1 114 LYS n 
1 115 GLU n 
1 116 ALA n 
1 117 GLY n 
1 118 ASP n 
1 119 ALA n 
1 120 GLU n 
1 121 SER n 
1 122 ARG n 
1 123 VAL n 
1 124 PHE n 
1 125 TYR n 
1 126 LEU n 
1 127 LYS n 
1 128 MET n 
1 129 LYS n 
1 130 GLY n 
1 131 ASP n 
1 132 TYR n 
1 133 TYR n 
1 134 ARG n 
1 135 TYR n 
1 136 LEU n 
1 137 ALA n 
1 138 GLU n 
1 139 VAL n 
1 140 ALA n 
1 141 THR n 
1 142 GLY n 
1 143 ASP n 
1 144 ASP n 
1 145 LYS n 
1 146 LYS n 
1 147 ARG n 
1 148 ILE n 
1 149 ILE n 
1 150 ASP n 
1 151 SER n 
1 152 ALA n 
1 153 ARG n 
1 154 SER n 
1 155 ALA n 
1 156 TYR n 
1 157 GLN n 
1 158 GLU n 
1 159 ALA n 
1 160 MET n 
1 161 ASP n 
1 162 ILE n 
1 163 SER n 
1 164 LYS n 
1 165 LYS n 
1 166 GLU n 
1 167 MET n 
1 168 PRO n 
1 169 PRO n 
1 170 THR n 
1 171 ASN n 
1 172 PRO n 
1 173 ILE n 
1 174 ARG n 
1 175 LEU n 
1 176 GLY n 
1 177 LEU n 
1 178 ALA n 
1 179 LEU n 
1 180 ASN n 
1 181 PHE n 
1 182 SER n 
1 183 VAL n 
1 184 PHE n 
1 185 HIS n 
1 186 TYR n 
1 187 GLU n 
1 188 ILE n 
1 189 ALA n 
1 190 ASN n 
1 191 SER n 
1 192 PRO n 
1 193 GLU n 
1 194 GLU n 
1 195 ALA n 
1 196 ILE n 
1 197 SER n 
1 198 LEU n 
1 199 ALA n 
1 200 LYS n 
1 201 THR n 
1 202 THR n 
1 203 PHE n 
1 204 ASP n 
1 205 GLU n 
1 206 ALA n 
1 207 MET n 
1 208 ALA n 
1 209 ASP n 
1 210 LEU n 
1 211 HIS n 
1 212 THR n 
1 213 LEU n 
1 214 SER n 
1 215 GLU n 
1 216 ASP n 
1 217 SER n 
1 218 TYR n 
1 219 LYS n 
1 220 ASP n 
1 221 SER n 
1 222 THR n 
1 223 LEU n 
1 224 ILE n 
1 225 MET n 
1 226 GLN n 
1 227 LEU n 
1 228 LEU n 
1 229 ARG n 
1 230 ASP n 
1 231 ASN n 
1 232 LEU n 
1 233 THR n 
1 234 LEU n 
1 235 TRP n 
1 236 THR n 
2 1   ARG n 
2 2   ASP n 
2 3   ARG n 
2 4   SER n 
2 5   SER n 
2 6   SEP n 
2 7   ALA n 
2 8   PRO n 
2 9   ASN n 
2 10  VAL n 
2 11  HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   236 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SFN, HME1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       11 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE           ?               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE          ?               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE        ?               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'   ?               'C4 H7 N O4'     133.103 
CSO 'L-peptide linking' n S-HYDROXYCYSTEINE ?               'C3 H7 N O3 S'   137.158 
CYS 'L-peptide linking' y CYSTEINE          ?               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE         ?               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'   ?               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE           ?               'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE         ?               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER             ?               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE        ?               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE           ?               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE            ?               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE        ?               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE     ?               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE           ?               'C5 H9 N O2'     115.130 
SEP 'L-peptide linking' n PHOSPHOSERINE     PHOSPHONOSERINE 'C3 H8 N O6 P'   185.072 
SER 'L-peptide linking' y SERINE            ?               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE         ?               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN        ?               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE          ?               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE            ?               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -4  -4  GLY GLY A . n 
A 1 2   ALA 2   -3  -3  ALA ALA A . n 
A 1 3   MET 3   -2  -2  MET MET A . n 
A 1 4   GLY 4   -1  -1  GLY GLY A . n 
A 1 5   SER 5   0   0   SER SER A . n 
A 1 6   MET 6   1   1   MET MET A . n 
A 1 7   GLU 7   2   2   GLU GLU A . n 
A 1 8   ARG 8   3   3   ARG ARG A . n 
A 1 9   ALA 9   4   4   ALA ALA A . n 
A 1 10  SER 10  5   5   SER SER A . n 
A 1 11  LEU 11  6   6   LEU LEU A . n 
A 1 12  ILE 12  7   7   ILE ILE A . n 
A 1 13  GLN 13  8   8   GLN GLN A . n 
A 1 14  LYS 14  9   9   LYS LYS A . n 
A 1 15  ALA 15  10  10  ALA ALA A . n 
A 1 16  LYS 16  11  11  LYS LYS A . n 
A 1 17  LEU 17  12  12  LEU LEU A . n 
A 1 18  ALA 18  13  13  ALA ALA A . n 
A 1 19  GLU 19  14  14  GLU GLU A . n 
A 1 20  GLN 20  15  15  GLN GLN A . n 
A 1 21  ALA 21  16  16  ALA ALA A . n 
A 1 22  GLU 22  17  17  GLU GLU A . n 
A 1 23  ARG 23  18  18  ARG ARG A . n 
A 1 24  TYR 24  19  19  TYR TYR A . n 
A 1 25  GLU 25  20  20  GLU GLU A . n 
A 1 26  ASP 26  21  21  ASP ASP A . n 
A 1 27  MET 27  22  22  MET MET A . n 
A 1 28  ALA 28  23  23  ALA ALA A . n 
A 1 29  ALA 29  24  24  ALA ALA A . n 
A 1 30  PHE 30  25  25  PHE PHE A . n 
A 1 31  MET 31  26  26  MET MET A . n 
A 1 32  LYS 32  27  27  LYS LYS A . n 
A 1 33  GLY 33  28  28  GLY GLY A . n 
A 1 34  ALA 34  29  29  ALA ALA A . n 
A 1 35  VAL 35  30  30  VAL VAL A . n 
A 1 36  GLU 36  31  31  GLU GLU A . n 
A 1 37  LYS 37  32  32  LYS LYS A . n 
A 1 38  GLY 38  33  33  GLY GLY A . n 
A 1 39  GLU 39  34  34  GLU GLU A . n 
A 1 40  GLU 40  35  35  GLU GLU A . n 
A 1 41  LEU 41  36  36  LEU LEU A . n 
A 1 42  SER 42  37  37  SER SER A . n 
A 1 43  CSO 43  38  38  CSO CSO A . n 
A 1 44  GLU 44  39  39  GLU GLU A . n 
A 1 45  GLU 45  40  40  GLU GLU A . n 
A 1 46  ARG 46  41  41  ARG ARG A . n 
A 1 47  ASN 47  42  42  ASN ASN A . n 
A 1 48  LEU 48  43  43  LEU LEU A . n 
A 1 49  LEU 49  44  44  LEU LEU A . n 
A 1 50  SER 50  45  45  SER SER A . n 
A 1 51  VAL 51  46  46  VAL VAL A . n 
A 1 52  ALA 52  47  47  ALA ALA A . n 
A 1 53  TYR 53  48  48  TYR TYR A . n 
A 1 54  LYS 54  49  49  LYS LYS A . n 
A 1 55  ASN 55  50  50  ASN ASN A . n 
A 1 56  VAL 56  51  51  VAL VAL A . n 
A 1 57  VAL 57  52  52  VAL VAL A . n 
A 1 58  GLY 58  53  53  GLY GLY A . n 
A 1 59  GLY 59  54  54  GLY GLY A . n 
A 1 60  GLN 60  55  55  GLN GLN A . n 
A 1 61  ARG 61  56  56  ARG ARG A . n 
A 1 62  ALA 62  57  57  ALA ALA A . n 
A 1 63  ALA 63  58  58  ALA ALA A . n 
A 1 64  TRP 64  59  59  TRP TRP A . n 
A 1 65  ARG 65  60  60  ARG ARG A . n 
A 1 66  VAL 66  61  61  VAL VAL A . n 
A 1 67  LEU 67  62  62  LEU LEU A . n 
A 1 68  SER 68  63  63  SER SER A . n 
A 1 69  SER 69  64  64  SER SER A . n 
A 1 70  ILE 70  65  65  ILE ILE A . n 
A 1 71  GLU 71  66  66  GLU GLU A . n 
A 1 72  GLN 72  67  67  GLN GLN A . n 
A 1 73  LYS 73  68  68  LYS LYS A . n 
A 1 74  SER 74  69  69  SER SER A . n 
A 1 75  ASN 75  70  70  ASN ASN A . n 
A 1 76  GLU 76  71  71  GLU GLU A . n 
A 1 77  GLU 77  72  ?   ?   ?   A . n 
A 1 78  GLY 78  73  ?   ?   ?   A . n 
A 1 79  SER 79  74  ?   ?   ?   A . n 
A 1 80  GLU 80  75  75  GLU GLU A . n 
A 1 81  GLU 81  76  76  GLU GLU A . n 
A 1 82  LYS 82  77  77  LYS LYS A . n 
A 1 83  GLY 83  78  78  GLY GLY A . n 
A 1 84  PRO 84  79  79  PRO PRO A . n 
A 1 85  GLU 85  80  80  GLU GLU A . n 
A 1 86  VAL 86  81  81  VAL VAL A . n 
A 1 87  ARG 87  82  82  ARG ARG A . n 
A 1 88  GLU 88  83  83  GLU GLU A . n 
A 1 89  TYR 89  84  84  TYR TYR A . n 
A 1 90  ARG 90  85  85  ARG ARG A . n 
A 1 91  GLU 91  86  86  GLU GLU A . n 
A 1 92  LYS 92  87  87  LYS LYS A . n 
A 1 93  VAL 93  88  88  VAL VAL A . n 
A 1 94  GLU 94  89  89  GLU GLU A . n 
A 1 95  THR 95  90  90  THR THR A . n 
A 1 96  GLU 96  91  91  GLU GLU A . n 
A 1 97  LEU 97  92  92  LEU LEU A . n 
A 1 98  GLN 98  93  93  GLN GLN A . n 
A 1 99  GLY 99  94  94  GLY GLY A . n 
A 1 100 VAL 100 95  95  VAL VAL A . n 
A 1 101 CYS 101 96  96  CYS CYS A . n 
A 1 102 ASP 102 97  97  ASP ASP A . n 
A 1 103 THR 103 98  98  THR THR A . n 
A 1 104 VAL 104 99  99  VAL VAL A . n 
A 1 105 LEU 105 100 100 LEU LEU A . n 
A 1 106 GLY 106 101 101 GLY GLY A . n 
A 1 107 LEU 107 102 102 LEU LEU A . n 
A 1 108 LEU 108 103 103 LEU LEU A . n 
A 1 109 ASP 109 104 104 ASP ASP A . n 
A 1 110 SER 110 105 105 SER SER A . n 
A 1 111 HIS 111 106 106 HIS HIS A . n 
A 1 112 LEU 112 107 107 LEU LEU A . n 
A 1 113 ILE 113 108 108 ILE ILE A . n 
A 1 114 LYS 114 109 109 LYS LYS A . n 
A 1 115 GLU 115 110 110 GLU GLU A . n 
A 1 116 ALA 116 111 111 ALA ALA A . n 
A 1 117 GLY 117 112 112 GLY GLY A . n 
A 1 118 ASP 118 113 113 ASP ASP A . n 
A 1 119 ALA 119 114 114 ALA ALA A . n 
A 1 120 GLU 120 115 115 GLU GLU A . n 
A 1 121 SER 121 116 116 SER SER A . n 
A 1 122 ARG 122 117 117 ARG ARG A . n 
A 1 123 VAL 123 118 118 VAL VAL A . n 
A 1 124 PHE 124 119 119 PHE PHE A . n 
A 1 125 TYR 125 120 120 TYR TYR A . n 
A 1 126 LEU 126 121 121 LEU LEU A . n 
A 1 127 LYS 127 122 122 LYS LYS A . n 
A 1 128 MET 128 123 123 MET MET A . n 
A 1 129 LYS 129 124 124 LYS LYS A . n 
A 1 130 GLY 130 125 125 GLY GLY A . n 
A 1 131 ASP 131 126 126 ASP ASP A . n 
A 1 132 TYR 132 127 127 TYR TYR A . n 
A 1 133 TYR 133 128 128 TYR TYR A . n 
A 1 134 ARG 134 129 129 ARG ARG A . n 
A 1 135 TYR 135 130 130 TYR TYR A . n 
A 1 136 LEU 136 131 131 LEU LEU A . n 
A 1 137 ALA 137 132 132 ALA ALA A . n 
A 1 138 GLU 138 133 133 GLU GLU A . n 
A 1 139 VAL 139 134 134 VAL VAL A . n 
A 1 140 ALA 140 135 135 ALA ALA A . n 
A 1 141 THR 141 136 136 THR THR A . n 
A 1 142 GLY 142 137 137 GLY GLY A . n 
A 1 143 ASP 143 138 138 ASP ASP A . n 
A 1 144 ASP 144 139 139 ASP ASP A . n 
A 1 145 LYS 145 140 140 LYS LYS A . n 
A 1 146 LYS 146 141 141 LYS LYS A . n 
A 1 147 ARG 147 142 142 ARG ARG A . n 
A 1 148 ILE 148 143 143 ILE ILE A . n 
A 1 149 ILE 149 144 144 ILE ILE A . n 
A 1 150 ASP 150 145 145 ASP ASP A . n 
A 1 151 SER 151 146 146 SER SER A . n 
A 1 152 ALA 152 147 147 ALA ALA A . n 
A 1 153 ARG 153 148 148 ARG ARG A . n 
A 1 154 SER 154 149 149 SER SER A . n 
A 1 155 ALA 155 150 150 ALA ALA A . n 
A 1 156 TYR 156 151 151 TYR TYR A . n 
A 1 157 GLN 157 152 152 GLN GLN A . n 
A 1 158 GLU 158 153 153 GLU GLU A . n 
A 1 159 ALA 159 154 154 ALA ALA A . n 
A 1 160 MET 160 155 155 MET MET A . n 
A 1 161 ASP 161 156 156 ASP ASP A . n 
A 1 162 ILE 162 157 157 ILE ILE A . n 
A 1 163 SER 163 158 158 SER SER A . n 
A 1 164 LYS 164 159 159 LYS LYS A . n 
A 1 165 LYS 165 160 160 LYS LYS A . n 
A 1 166 GLU 166 161 161 GLU GLU A . n 
A 1 167 MET 167 162 162 MET MET A . n 
A 1 168 PRO 168 163 163 PRO PRO A . n 
A 1 169 PRO 169 164 164 PRO PRO A . n 
A 1 170 THR 170 165 165 THR THR A . n 
A 1 171 ASN 171 166 166 ASN ASN A . n 
A 1 172 PRO 172 167 167 PRO PRO A . n 
A 1 173 ILE 173 168 168 ILE ILE A . n 
A 1 174 ARG 174 169 169 ARG ARG A . n 
A 1 175 LEU 175 170 170 LEU LEU A . n 
A 1 176 GLY 176 171 171 GLY GLY A . n 
A 1 177 LEU 177 172 ?   ?   ?   A . n 
A 1 178 ALA 178 173 173 ALA ALA A . n 
A 1 179 LEU 179 174 174 LEU LEU A . n 
A 1 180 ASN 180 175 175 ASN ASN A . n 
A 1 181 PHE 181 176 176 PHE PHE A . n 
A 1 182 SER 182 177 177 SER SER A . n 
A 1 183 VAL 183 178 178 VAL VAL A . n 
A 1 184 PHE 184 179 179 PHE PHE A . n 
A 1 185 HIS 185 180 180 HIS HIS A . n 
A 1 186 TYR 186 181 181 TYR TYR A . n 
A 1 187 GLU 187 182 182 GLU GLU A . n 
A 1 188 ILE 188 183 183 ILE ILE A . n 
A 1 189 ALA 189 184 184 ALA ALA A . n 
A 1 190 ASN 190 185 185 ASN ASN A . n 
A 1 191 SER 191 186 186 SER SER A . n 
A 1 192 PRO 192 187 187 PRO PRO A . n 
A 1 193 GLU 193 188 188 GLU GLU A . n 
A 1 194 GLU 194 189 189 GLU GLU A . n 
A 1 195 ALA 195 190 190 ALA ALA A . n 
A 1 196 ILE 196 191 191 ILE ILE A . n 
A 1 197 SER 197 192 192 SER SER A . n 
A 1 198 LEU 198 193 193 LEU LEU A . n 
A 1 199 ALA 199 194 194 ALA ALA A . n 
A 1 200 LYS 200 195 195 LYS LYS A . n 
A 1 201 THR 201 196 196 THR THR A . n 
A 1 202 THR 202 197 197 THR THR A . n 
A 1 203 PHE 203 198 198 PHE PHE A . n 
A 1 204 ASP 204 199 199 ASP ASP A . n 
A 1 205 GLU 205 200 200 GLU GLU A . n 
A 1 206 ALA 206 201 201 ALA ALA A . n 
A 1 207 MET 207 202 202 MET MET A . n 
A 1 208 ALA 208 203 203 ALA ALA A . n 
A 1 209 ASP 209 204 204 ASP ASP A . n 
A 1 210 LEU 210 205 205 LEU LEU A . n 
A 1 211 HIS 211 206 206 HIS HIS A . n 
A 1 212 THR 212 207 207 THR THR A . n 
A 1 213 LEU 213 208 208 LEU LEU A . n 
A 1 214 SER 214 209 209 SER SER A . n 
A 1 215 GLU 215 210 210 GLU GLU A . n 
A 1 216 ASP 216 211 211 ASP ASP A . n 
A 1 217 SER 217 212 212 SER SER A . n 
A 1 218 TYR 218 213 213 TYR TYR A . n 
A 1 219 LYS 219 214 214 LYS LYS A . n 
A 1 220 ASP 220 215 215 ASP ASP A . n 
A 1 221 SER 221 216 216 SER SER A . n 
A 1 222 THR 222 217 217 THR THR A . n 
A 1 223 LEU 223 218 218 LEU LEU A . n 
A 1 224 ILE 224 219 219 ILE ILE A . n 
A 1 225 MET 225 220 220 MET MET A . n 
A 1 226 GLN 226 221 221 GLN GLN A . n 
A 1 227 LEU 227 222 222 LEU LEU A . n 
A 1 228 LEU 228 223 223 LEU LEU A . n 
A 1 229 ARG 229 224 224 ARG ARG A . n 
A 1 230 ASP 230 225 225 ASP ASP A . n 
A 1 231 ASN 231 226 226 ASN ASN A . n 
A 1 232 LEU 232 227 227 LEU LEU A . n 
A 1 233 THR 233 228 228 THR THR A . n 
A 1 234 LEU 234 229 229 LEU LEU A . n 
A 1 235 TRP 235 230 230 TRP TRP A . n 
A 1 236 THR 236 231 231 THR THR A . n 
B 2 1   ARG 1   360 ?   ?   ?   B . n 
B 2 2   ASP 2   361 361 ASP ASP B . n 
B 2 3   ARG 3   362 362 ARG ARG B . n 
B 2 4   SER 4   363 363 SER SER B . n 
B 2 5   SER 5   364 364 SER SER B . n 
B 2 6   SEP 6   365 365 SEP SEP B . n 
B 2 7   ALA 7   366 366 ALA ALA B . n 
B 2 8   PRO 8   367 367 PRO PRO B . n 
B 2 9   ASN 9   368 368 ASN ASN B . n 
B 2 10  VAL 10  369 369 VAL VAL B . n 
B 2 11  HIS 11  370 370 HIS HIS B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 CSO ? ? CSO ? ? 'SUBJECT OF INVESTIGATION' ? 
2 SEP ? ? SEP ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 HOH 1   301 23  HOH HOH A . 
C 3 HOH 2   302 1   HOH HOH A . 
C 3 HOH 3   303 199 HOH HOH A . 
C 3 HOH 4   304 95  HOH HOH A . 
C 3 HOH 5   305 76  HOH HOH A . 
C 3 HOH 6   306 24  HOH HOH A . 
C 3 HOH 7   307 189 HOH HOH A . 
C 3 HOH 8   308 56  HOH HOH A . 
C 3 HOH 9   309 62  HOH HOH A . 
C 3 HOH 10  310 15  HOH HOH A . 
C 3 HOH 11  311 136 HOH HOH A . 
C 3 HOH 12  312 188 HOH HOH A . 
C 3 HOH 13  313 197 HOH HOH A . 
C 3 HOH 14  314 63  HOH HOH A . 
C 3 HOH 15  315 176 HOH HOH A . 
C 3 HOH 16  316 7   HOH HOH A . 
C 3 HOH 17  317 47  HOH HOH A . 
C 3 HOH 18  318 155 HOH HOH A . 
C 3 HOH 19  319 145 HOH HOH A . 
C 3 HOH 20  320 125 HOH HOH A . 
C 3 HOH 21  321 129 HOH HOH A . 
C 3 HOH 22  322 30  HOH HOH A . 
C 3 HOH 23  323 51  HOH HOH A . 
C 3 HOH 24  324 11  HOH HOH A . 
C 3 HOH 25  325 2   HOH HOH A . 
C 3 HOH 26  326 201 HOH HOH A . 
C 3 HOH 27  327 74  HOH HOH A . 
C 3 HOH 28  328 82  HOH HOH A . 
C 3 HOH 29  329 204 HOH HOH A . 
C 3 HOH 30  330 59  HOH HOH A . 
C 3 HOH 31  331 200 HOH HOH A . 
C 3 HOH 32  332 128 HOH HOH A . 
C 3 HOH 33  333 182 HOH HOH A . 
C 3 HOH 34  334 4   HOH HOH A . 
C 3 HOH 35  335 97  HOH HOH A . 
C 3 HOH 36  336 169 HOH HOH A . 
C 3 HOH 37  337 139 HOH HOH A . 
C 3 HOH 38  338 9   HOH HOH A . 
C 3 HOH 39  339 120 HOH HOH A . 
C 3 HOH 40  340 69  HOH HOH A . 
C 3 HOH 41  341 42  HOH HOH A . 
C 3 HOH 42  342 164 HOH HOH A . 
C 3 HOH 43  343 160 HOH HOH A . 
C 3 HOH 44  344 109 HOH HOH A . 
C 3 HOH 45  345 92  HOH HOH A . 
C 3 HOH 46  346 126 HOH HOH A . 
C 3 HOH 47  347 45  HOH HOH A . 
C 3 HOH 48  348 14  HOH HOH A . 
C 3 HOH 49  349 90  HOH HOH A . 
C 3 HOH 50  350 6   HOH HOH A . 
C 3 HOH 51  351 37  HOH HOH A . 
C 3 HOH 52  352 80  HOH HOH A . 
C 3 HOH 53  353 39  HOH HOH A . 
C 3 HOH 54  354 8   HOH HOH A . 
C 3 HOH 55  355 28  HOH HOH A . 
C 3 HOH 56  356 22  HOH HOH A . 
C 3 HOH 57  357 73  HOH HOH A . 
C 3 HOH 58  358 12  HOH HOH A . 
C 3 HOH 59  359 91  HOH HOH A . 
C 3 HOH 60  360 151 HOH HOH A . 
C 3 HOH 61  361 36  HOH HOH A . 
C 3 HOH 62  362 161 HOH HOH A . 
C 3 HOH 63  363 142 HOH HOH A . 
C 3 HOH 64  364 61  HOH HOH A . 
C 3 HOH 65  365 193 HOH HOH A . 
C 3 HOH 66  366 163 HOH HOH A . 
C 3 HOH 67  367 35  HOH HOH A . 
C 3 HOH 68  368 33  HOH HOH A . 
C 3 HOH 69  369 55  HOH HOH A . 
C 3 HOH 70  370 111 HOH HOH A . 
C 3 HOH 71  371 10  HOH HOH A . 
C 3 HOH 72  372 29  HOH HOH A . 
C 3 HOH 73  373 175 HOH HOH A . 
C 3 HOH 74  374 20  HOH HOH A . 
C 3 HOH 75  375 77  HOH HOH A . 
C 3 HOH 76  376 18  HOH HOH A . 
C 3 HOH 77  377 50  HOH HOH A . 
C 3 HOH 78  378 26  HOH HOH A . 
C 3 HOH 79  379 60  HOH HOH A . 
C 3 HOH 80  380 49  HOH HOH A . 
C 3 HOH 81  381 31  HOH HOH A . 
C 3 HOH 82  382 152 HOH HOH A . 
C 3 HOH 83  383 184 HOH HOH A . 
C 3 HOH 84  384 5   HOH HOH A . 
C 3 HOH 85  385 186 HOH HOH A . 
C 3 HOH 86  386 17  HOH HOH A . 
C 3 HOH 87  387 27  HOH HOH A . 
C 3 HOH 88  388 84  HOH HOH A . 
C 3 HOH 89  389 81  HOH HOH A . 
C 3 HOH 90  390 19  HOH HOH A . 
C 3 HOH 91  391 133 HOH HOH A . 
C 3 HOH 92  392 187 HOH HOH A . 
C 3 HOH 93  393 72  HOH HOH A . 
C 3 HOH 94  394 131 HOH HOH A . 
C 3 HOH 95  395 68  HOH HOH A . 
C 3 HOH 96  396 143 HOH HOH A . 
C 3 HOH 97  397 43  HOH HOH A . 
C 3 HOH 98  398 88  HOH HOH A . 
C 3 HOH 99  399 54  HOH HOH A . 
C 3 HOH 100 400 64  HOH HOH A . 
C 3 HOH 101 401 179 HOH HOH A . 
C 3 HOH 102 402 181 HOH HOH A . 
C 3 HOH 103 403 32  HOH HOH A . 
C 3 HOH 104 404 132 HOH HOH A . 
C 3 HOH 105 405 38  HOH HOH A . 
C 3 HOH 106 406 13  HOH HOH A . 
C 3 HOH 107 407 177 HOH HOH A . 
C 3 HOH 108 408 16  HOH HOH A . 
C 3 HOH 109 409 52  HOH HOH A . 
C 3 HOH 110 410 137 HOH HOH A . 
C 3 HOH 111 411 94  HOH HOH A . 
C 3 HOH 112 412 40  HOH HOH A . 
C 3 HOH 113 413 103 HOH HOH A . 
C 3 HOH 114 414 159 HOH HOH A . 
C 3 HOH 115 415 44  HOH HOH A . 
C 3 HOH 116 416 170 HOH HOH A . 
C 3 HOH 117 417 71  HOH HOH A . 
C 3 HOH 118 418 46  HOH HOH A . 
C 3 HOH 119 419 78  HOH HOH A . 
C 3 HOH 120 420 41  HOH HOH A . 
C 3 HOH 121 421 58  HOH HOH A . 
C 3 HOH 122 422 174 HOH HOH A . 
C 3 HOH 123 423 148 HOH HOH A . 
C 3 HOH 124 424 190 HOH HOH A . 
C 3 HOH 125 425 191 HOH HOH A . 
C 3 HOH 126 426 93  HOH HOH A . 
C 3 HOH 127 427 104 HOH HOH A . 
C 3 HOH 128 428 121 HOH HOH A . 
C 3 HOH 129 429 102 HOH HOH A . 
C 3 HOH 130 430 79  HOH HOH A . 
C 3 HOH 131 431 119 HOH HOH A . 
C 3 HOH 132 432 149 HOH HOH A . 
C 3 HOH 133 433 106 HOH HOH A . 
C 3 HOH 134 434 135 HOH HOH A . 
C 3 HOH 135 435 112 HOH HOH A . 
C 3 HOH 136 436 198 HOH HOH A . 
C 3 HOH 137 437 99  HOH HOH A . 
C 3 HOH 138 438 180 HOH HOH A . 
C 3 HOH 139 439 205 HOH HOH A . 
C 3 HOH 140 440 75  HOH HOH A . 
C 3 HOH 141 441 34  HOH HOH A . 
C 3 HOH 142 442 53  HOH HOH A . 
C 3 HOH 143 443 134 HOH HOH A . 
C 3 HOH 144 444 156 HOH HOH A . 
C 3 HOH 145 445 21  HOH HOH A . 
C 3 HOH 146 446 57  HOH HOH A . 
C 3 HOH 147 447 25  HOH HOH A . 
C 3 HOH 148 448 140 HOH HOH A . 
C 3 HOH 149 449 165 HOH HOH A . 
C 3 HOH 150 450 118 HOH HOH A . 
C 3 HOH 151 451 124 HOH HOH A . 
C 3 HOH 152 452 144 HOH HOH A . 
C 3 HOH 153 453 173 HOH HOH A . 
C 3 HOH 154 454 123 HOH HOH A . 
C 3 HOH 155 455 147 HOH HOH A . 
C 3 HOH 156 456 146 HOH HOH A . 
C 3 HOH 157 457 158 HOH HOH A . 
C 3 HOH 158 458 166 HOH HOH A . 
C 3 HOH 159 459 87  HOH HOH A . 
C 3 HOH 160 460 48  HOH HOH A . 
C 3 HOH 161 461 192 HOH HOH A . 
C 3 HOH 162 462 65  HOH HOH A . 
C 3 HOH 163 463 66  HOH HOH A . 
C 3 HOH 164 464 168 HOH HOH A . 
C 3 HOH 165 465 178 HOH HOH A . 
C 3 HOH 166 466 110 HOH HOH A . 
C 3 HOH 167 467 86  HOH HOH A . 
C 3 HOH 168 468 138 HOH HOH A . 
C 3 HOH 169 469 113 HOH HOH A . 
C 3 HOH 170 470 167 HOH HOH A . 
C 3 HOH 171 471 85  HOH HOH A . 
C 3 HOH 172 472 107 HOH HOH A . 
C 3 HOH 173 473 150 HOH HOH A . 
C 3 HOH 174 474 172 HOH HOH A . 
C 3 HOH 175 475 105 HOH HOH A . 
C 3 HOH 176 476 89  HOH HOH A . 
C 3 HOH 177 477 127 HOH HOH A . 
C 3 HOH 178 478 83  HOH HOH A . 
C 3 HOH 179 479 196 HOH HOH A . 
C 3 HOH 180 480 162 HOH HOH A . 
C 3 HOH 181 481 70  HOH HOH A . 
C 3 HOH 182 482 117 HOH HOH A . 
C 3 HOH 183 483 67  HOH HOH A . 
C 3 HOH 184 484 171 HOH HOH A . 
C 3 HOH 185 485 203 HOH HOH A . 
C 3 HOH 186 486 183 HOH HOH A . 
C 3 HOH 187 487 108 HOH HOH A . 
C 3 HOH 188 488 122 HOH HOH A . 
C 3 HOH 189 489 114 HOH HOH A . 
C 3 HOH 190 490 130 HOH HOH A . 
D 3 HOH 1   401 98  HOH HOH B . 
D 3 HOH 2   402 195 HOH HOH B . 
D 3 HOH 3   403 3   HOH HOH B . 
D 3 HOH 4   404 153 HOH HOH B . 
D 3 HOH 5   405 141 HOH HOH B . 
D 3 HOH 6   406 154 HOH HOH B . 
D 3 HOH 7   407 202 HOH HOH B . 
D 3 HOH 8   408 96  HOH HOH B . 
D 3 HOH 9   409 194 HOH HOH B . 
D 3 HOH 10  410 101 HOH HOH B . 
D 3 HOH 11  411 115 HOH HOH B . 
D 3 HOH 12  412 157 HOH HOH B . 
D 3 HOH 13  413 185 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 68  ? CG  ? A LYS 73  CG  
2  1 Y 1 A LYS 68  ? CD  ? A LYS 73  CD  
3  1 Y 1 A LYS 68  ? CE  ? A LYS 73  CE  
4  1 Y 1 A LYS 68  ? NZ  ? A LYS 73  NZ  
5  1 Y 1 A GLU 71  ? CG  ? A GLU 76  CG  
6  1 Y 1 A GLU 71  ? CD  ? A GLU 76  CD  
7  1 Y 1 A GLU 71  ? OE1 ? A GLU 76  OE1 
8  1 Y 1 A GLU 71  ? OE2 ? A GLU 76  OE2 
9  1 Y 1 A LYS 77  ? CG  ? A LYS 82  CG  
10 1 Y 1 A LYS 77  ? CD  ? A LYS 82  CD  
11 1 Y 1 A LYS 77  ? CE  ? A LYS 82  CE  
12 1 Y 1 A LYS 77  ? NZ  ? A LYS 82  NZ  
13 1 Y 1 A ASP 138 ? CG  ? A ASP 143 CG  
14 1 Y 1 A ASP 138 ? OD1 ? A ASP 143 OD1 
15 1 Y 1 A ASP 138 ? OD2 ? A ASP 143 OD2 
16 1 Y 1 A ASP 139 ? CG  ? A ASP 144 CG  
17 1 Y 1 A ASP 139 ? OD1 ? A ASP 144 OD1 
18 1 Y 1 A ASP 139 ? OD2 ? A ASP 144 OD2 
19 1 Y 1 A LYS 141 ? CG  ? A LYS 146 CG  
20 1 Y 1 A LYS 141 ? CD  ? A LYS 146 CD  
21 1 Y 1 A LYS 141 ? CE  ? A LYS 146 CE  
22 1 Y 1 A LYS 141 ? NZ  ? A LYS 146 NZ  
23 1 Y 1 A LYS 159 ? CG  ? A LYS 164 CG  
24 1 Y 1 A LYS 159 ? CD  ? A LYS 164 CD  
25 1 Y 1 A LYS 159 ? CE  ? A LYS 164 CE  
26 1 Y 1 A LYS 159 ? NZ  ? A LYS 164 NZ  
27 1 Y 1 B ARG 362 ? CG  ? B ARG 3   CG  
28 1 Y 1 B ARG 362 ? CD  ? B ARG 3   CD  
29 1 Y 1 B ARG 362 ? NE  ? B ARG 3   NE  
30 1 Y 1 B ARG 362 ? CZ  ? B ARG 3   CZ  
31 1 Y 1 B ARG 362 ? NH1 ? B ARG 3   NH1 
32 1 Y 1 B ARG 362 ? NH2 ? B ARG 3   NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DIALS   ? ? ? .           2 
? 'model building' ? ? ? ? ? ? ? ? ? ? ? Coot    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .           4 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9F35 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     84.782 
_cell.length_a_esd                 ? 
_cell.length_b                     115.252 
_cell.length_b_esd                 ? 
_cell.length_c                     64.671 
_cell.length_c_esd                 ? 
_cell.volume                       631919.423 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9F35 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            'C 2c 2' 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9F35 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.84 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.76 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M Hepes pH 7.5, 28% PEG400, 0.2M Cacl2, 5% Glycerol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-02-05 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    M 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.969 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID30B' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.969 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID30B 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          19.35 
_reflns.entry_id                                       9F35 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.299 
_reflns.d_resolution_low                               57.63 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     14439 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     3.7 
_reflns.percent_possible_obs                           99.92 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.74 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          3.7 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.974 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.299 
_reflns_shell.d_res_low                                     2.381 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1417 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.946 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.72 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               26.92 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9F35 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.30 
_refine.ls_d_res_low                             57.63 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     14439 
_refine.ls_number_reflns_R_free                  706 
_refine.ls_number_reflns_R_work                  13733 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.92 
_refine.ls_percent_reflns_R_free                 4.89 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2127 
_refine.ls_R_factor_R_free                       0.2982 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2083 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 31.8325 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3620 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.30 
_refine_hist.d_res_low                        57.63 
_refine_hist.number_atoms_solvent             203 
_refine_hist.number_atoms_total               2079 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1876 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0132  ? 1953 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.2811  ? 2637 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0488  ? 290  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0103  ? 347  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.6024 ? 280  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.30 2.48  . . 139 2696 99.82  . . . . 0.3040 . . . . . . . . . . . 0.3812 
'X-RAY DIFFRACTION' 2.48 2.73  . . 142 2691 99.96  . . . . 0.2458 . . . . . . . . . . . 0.3159 
'X-RAY DIFFRACTION' 2.73 3.12  . . 134 2744 100.00 . . . . 0.2304 . . . . . . . . . . . 0.3353 
'X-RAY DIFFRACTION' 3.12 3.93  . . 149 2731 100.00 . . . . 0.1720 . . . . . . . . . . . 0.2939 
'X-RAY DIFFRACTION' 3.93 57.63 . . 142 2871 99.83  . . . . 0.1760 . . . . . . . . . . . 0.2437 
# 
_struct.entry_id                     9F35 
_struct.title                        'Co-crystal structure of 14-3-3sigma in complex with B-Raf pS365 phosphopeptide' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9F35 
_struct_keywords.text            'Protein-peptide interaction, PEPTIDE BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'PEPTIDE BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP 1433S_HUMAN P31947 ? 1 
;MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPE
VREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKK
EMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
;
1 
2 PDB 9F35        9F35   ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9F35 A 6 ? 236 ? P31947 1   ? 231 ? 1   231 
2 2 9F35 B 1 ? 11  ? 9F35   360 ? 370 ? 360 370 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9F35 GLY A 1 ? UNP P31947 ? ? 'expression tag' -4 1 
1 9F35 ALA A 2 ? UNP P31947 ? ? 'expression tag' -3 2 
1 9F35 MET A 3 ? UNP P31947 ? ? 'expression tag' -2 3 
1 9F35 GLY A 4 ? UNP P31947 ? ? 'expression tag' -1 4 
1 9F35 SER A 5 ? UNP P31947 ? ? 'expression tag' 0  5 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4420  ? 
1 MORE         -24   ? 
1 'SSA (A^2)'  24780 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z   1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 4_555 x,-y,-z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 7   ? GLU A 22  ? GLU A 2   GLU A 17  1 ? 16 
HELX_P HELX_P2  AA2 ARG A 23  ? GLU A 36  ? ARG A 18  GLU A 31  1 ? 14 
HELX_P HELX_P3  AA3 SER A 42  ? SER A 74  ? SER A 37  SER A 69  1 ? 33 
HELX_P HELX_P4  AA4 PRO A 84  ? ASP A 109 ? PRO A 79  ASP A 104 1 ? 26 
HELX_P HELX_P5  AA5 HIS A 111 ? ALA A 116 ? HIS A 106 ALA A 111 1 ? 6  
HELX_P HELX_P6  AA6 ASP A 118 ? GLU A 138 ? ASP A 113 GLU A 133 1 ? 21 
HELX_P HELX_P7  AA7 ASP A 143 ? MET A 167 ? ASP A 138 MET A 162 1 ? 25 
HELX_P HELX_P8  AA8 ASN A 171 ? GLY A 176 ? ASN A 166 GLY A 171 1 ? 6  
HELX_P HELX_P9  AA9 LEU A 179 ? ILE A 188 ? LEU A 174 ILE A 183 1 ? 10 
HELX_P HELX_P10 AB1 SER A 191 ? ALA A 208 ? SER A 186 ALA A 203 1 ? 18 
HELX_P HELX_P11 AB2 ASP A 209 ? LEU A 213 ? ASP A 204 LEU A 208 5 ? 5  
HELX_P HELX_P12 AB3 SER A 214 ? THR A 236 ? SER A 209 THR A 231 1 ? 23 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A SER 42 C ? ? ? 1_555 A CSO 43 N A ? A SER 37  A CSO 38  1_555 ? ? ? ? ? ? ? 1.333 ? ? 
covale2 covale both ? A SER 42 C ? ? ? 1_555 A CSO 43 N B ? A SER 37  A CSO 38  1_555 ? ? ? ? ? ? ? 1.323 ? ? 
covale3 covale both ? A CSO 43 C A ? ? 1_555 A GLU 44 N ? ? A CSO 38  A GLU 39  1_555 ? ? ? ? ? ? ? 1.327 ? ? 
covale4 covale both ? A CSO 43 C B ? ? 1_555 A GLU 44 N ? ? A CSO 38  A GLU 39  1_555 ? ? ? ? ? ? ? 1.338 ? ? 
covale5 covale both ? B SER 5  C ? ? ? 1_555 B SEP 6  N ? ? B SER 364 B SEP 365 1_555 ? ? ? ? ? ? ? 1.336 ? ? 
covale6 covale both ? B SEP 6  C ? ? ? 1_555 B ALA 7  N ? ? B SEP 365 B ALA 366 1_555 ? ? ? ? ? ? ? 1.323 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CSO A 43 A . . . . CSO A 38  ? 1_555 . . . . . . . CYS 1 CSO Hydroxylation   'Named protein modification' 
2 CSO A 43 B . . . . CSO A 38  ? 1_555 . . . . . . . CYS 1 CSO Hydroxylation   'Named protein modification' 
3 SEP B 6  ? . . . . SEP B 365 ? 1_555 . . . . . . . SER 1 SEP Phosphorylation 'Named protein modification' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          SER 
_struct_mon_prot_cis.label_seq_id           110 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           SER 
_struct_mon_prot_cis.auth_seq_id            105 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   HIS 
_struct_mon_prot_cis.pdbx_label_seq_id_2    111 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    HIS 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     106 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       8.43 
# 
_pdbx_entry_details.entry_id                   9F35 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 HZ1  A LYS 49  ? ? O A HOH 305 ? ? 1.25 
2  1 HH11 A ARG 148 ? A O A HOH 306 ? ? 1.40 
3  1 O    A HOH 308 ? ? O A HOH 413 ? ? 1.73 
4  1 OH   A TYR 127 ? ? O A HOH 301 ? ? 1.90 
5  1 OE2  A GLU 188 ? ? O A HOH 302 ? ? 1.97 
6  1 OD1  A ASP 215 ? ? O A HOH 303 ? ? 1.98 
7  1 OE2  A GLU 110 ? A O A HOH 304 ? ? 2.07 
8  1 O    A HOH 455 ? ? O A HOH 473 ? ? 2.11 
9  1 O    A HOH 436 ? ? O A HOH 439 ? ? 2.12 
10 1 NZ   A LYS 49  ? ? O A HOH 305 ? ? 2.13 
11 1 NH1  A ARG 148 ? A O A HOH 306 ? ? 2.14 
12 1 O    A HOH 311 ? ? O A HOH 468 ? ? 2.18 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OE2 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    GLU 
_pdbx_validate_symm_contact.auth_seq_id_1     110 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    A 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    HH 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    TYR 
_pdbx_validate_symm_contact.auth_seq_id_2     213 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   8_555 
_pdbx_validate_symm_contact.dist              1.59 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 18  ? ? -118.68 75.79 
2 1 SER A 69  ? ? -76.13  22.45 
3 1 SER A 105 ? ? -150.94 74.27 
4 1 HIS A 106 ? ? -140.84 40.25 
5 1 ASP A 139 ? ? -69.26  3.10  
# 
_pdbx_struct_mod_residue.id               1 
_pdbx_struct_mod_residue.label_asym_id    A 
_pdbx_struct_mod_residue.label_comp_id    CSO 
_pdbx_struct_mod_residue.label_seq_id     43 
_pdbx_struct_mod_residue.auth_asym_id     A 
_pdbx_struct_mod_residue.auth_comp_id     CSO 
_pdbx_struct_mod_residue.auth_seq_id      38 
_pdbx_struct_mod_residue.PDB_ins_code     ? 
_pdbx_struct_mod_residue.parent_comp_id   CYS 
_pdbx_struct_mod_residue.details          'modified residue' 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 313 ? C HOH . 
2 1 A HOH 373 ? C HOH . 
3 1 A HOH 488 ? C HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 x,-y,-z             
3 -x,y,-z+1/2         
4 -x,-y,z+1/2         
5 x+1/2,y+1/2,z       
6 x+1/2,-y+1/2,-z     
7 -x+1/2,y+1/2,-z+1/2 
8 -x+1/2,-y+1/2,z+1/2 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 487 ? 5.84 . 
2 1 O ? A HOH 488 ? 6.23 . 
3 1 O ? A HOH 489 ? 6.36 . 
4 1 O ? A HOH 490 ? 7.78 . 
5 1 O ? B HOH 409 ? 5.85 . 
6 1 O ? B HOH 410 ? 5.88 . 
7 1 O ? B HOH 411 ? 6.65 . 
8 1 O ? B HOH 412 ? 8.10 . 
9 1 O ? B HOH 413 ? 8.29 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLU 72  ? A GLU 77  
2 1 Y 1 A GLY 73  ? A GLY 78  
3 1 Y 1 A SER 74  ? A SER 79  
4 1 Y 1 A LEU 172 ? A LEU 177 
5 1 Y 1 B ARG 360 ? B ARG 1   
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CSO N    N N N 74  
CSO CA   C N R 75  
CSO CB   C N N 76  
CSO SG   S N N 77  
CSO C    C N N 78  
CSO O    O N N 79  
CSO OXT  O N N 80  
CSO OD   O N N 81  
CSO H    H N N 82  
CSO H2   H N N 83  
CSO HA   H N N 84  
CSO HB2  H N N 85  
CSO HB3  H N N 86  
CSO HXT  H N N 87  
CSO HD   H N N 88  
CYS N    N N N 89  
CYS CA   C N R 90  
CYS C    C N N 91  
CYS O    O N N 92  
CYS CB   C N N 93  
CYS SG   S N N 94  
CYS OXT  O N N 95  
CYS H    H N N 96  
CYS H2   H N N 97  
CYS HA   H N N 98  
CYS HB2  H N N 99  
CYS HB3  H N N 100 
CYS HG   H N N 101 
CYS HXT  H N N 102 
GLN N    N N N 103 
GLN CA   C N S 104 
GLN C    C N N 105 
GLN O    O N N 106 
GLN CB   C N N 107 
GLN CG   C N N 108 
GLN CD   C N N 109 
GLN OE1  O N N 110 
GLN NE2  N N N 111 
GLN OXT  O N N 112 
GLN H    H N N 113 
GLN H2   H N N 114 
GLN HA   H N N 115 
GLN HB2  H N N 116 
GLN HB3  H N N 117 
GLN HG2  H N N 118 
GLN HG3  H N N 119 
GLN HE21 H N N 120 
GLN HE22 H N N 121 
GLN HXT  H N N 122 
GLU N    N N N 123 
GLU CA   C N S 124 
GLU C    C N N 125 
GLU O    O N N 126 
GLU CB   C N N 127 
GLU CG   C N N 128 
GLU CD   C N N 129 
GLU OE1  O N N 130 
GLU OE2  O N N 131 
GLU OXT  O N N 132 
GLU H    H N N 133 
GLU H2   H N N 134 
GLU HA   H N N 135 
GLU HB2  H N N 136 
GLU HB3  H N N 137 
GLU HG2  H N N 138 
GLU HG3  H N N 139 
GLU HE2  H N N 140 
GLU HXT  H N N 141 
GLY N    N N N 142 
GLY CA   C N N 143 
GLY C    C N N 144 
GLY O    O N N 145 
GLY OXT  O N N 146 
GLY H    H N N 147 
GLY H2   H N N 148 
GLY HA2  H N N 149 
GLY HA3  H N N 150 
GLY HXT  H N N 151 
HIS N    N N N 152 
HIS CA   C N S 153 
HIS C    C N N 154 
HIS O    O N N 155 
HIS CB   C N N 156 
HIS CG   C Y N 157 
HIS ND1  N Y N 158 
HIS CD2  C Y N 159 
HIS CE1  C Y N 160 
HIS NE2  N Y N 161 
HIS OXT  O N N 162 
HIS H    H N N 163 
HIS H2   H N N 164 
HIS HA   H N N 165 
HIS HB2  H N N 166 
HIS HB3  H N N 167 
HIS HD1  H N N 168 
HIS HD2  H N N 169 
HIS HE1  H N N 170 
HIS HE2  H N N 171 
HIS HXT  H N N 172 
HOH O    O N N 173 
HOH H1   H N N 174 
HOH H2   H N N 175 
ILE N    N N N 176 
ILE CA   C N S 177 
ILE C    C N N 178 
ILE O    O N N 179 
ILE CB   C N S 180 
ILE CG1  C N N 181 
ILE CG2  C N N 182 
ILE CD1  C N N 183 
ILE OXT  O N N 184 
ILE H    H N N 185 
ILE H2   H N N 186 
ILE HA   H N N 187 
ILE HB   H N N 188 
ILE HG12 H N N 189 
ILE HG13 H N N 190 
ILE HG21 H N N 191 
ILE HG22 H N N 192 
ILE HG23 H N N 193 
ILE HD11 H N N 194 
ILE HD12 H N N 195 
ILE HD13 H N N 196 
ILE HXT  H N N 197 
LEU N    N N N 198 
LEU CA   C N S 199 
LEU C    C N N 200 
LEU O    O N N 201 
LEU CB   C N N 202 
LEU CG   C N N 203 
LEU CD1  C N N 204 
LEU CD2  C N N 205 
LEU OXT  O N N 206 
LEU H    H N N 207 
LEU H2   H N N 208 
LEU HA   H N N 209 
LEU HB2  H N N 210 
LEU HB3  H N N 211 
LEU HG   H N N 212 
LEU HD11 H N N 213 
LEU HD12 H N N 214 
LEU HD13 H N N 215 
LEU HD21 H N N 216 
LEU HD22 H N N 217 
LEU HD23 H N N 218 
LEU HXT  H N N 219 
LYS N    N N N 220 
LYS CA   C N S 221 
LYS C    C N N 222 
LYS O    O N N 223 
LYS CB   C N N 224 
LYS CG   C N N 225 
LYS CD   C N N 226 
LYS CE   C N N 227 
LYS NZ   N N N 228 
LYS OXT  O N N 229 
LYS H    H N N 230 
LYS H2   H N N 231 
LYS HA   H N N 232 
LYS HB2  H N N 233 
LYS HB3  H N N 234 
LYS HG2  H N N 235 
LYS HG3  H N N 236 
LYS HD2  H N N 237 
LYS HD3  H N N 238 
LYS HE2  H N N 239 
LYS HE3  H N N 240 
LYS HZ1  H N N 241 
LYS HZ2  H N N 242 
LYS HZ3  H N N 243 
LYS HXT  H N N 244 
MET N    N N N 245 
MET CA   C N S 246 
MET C    C N N 247 
MET O    O N N 248 
MET CB   C N N 249 
MET CG   C N N 250 
MET SD   S N N 251 
MET CE   C N N 252 
MET OXT  O N N 253 
MET H    H N N 254 
MET H2   H N N 255 
MET HA   H N N 256 
MET HB2  H N N 257 
MET HB3  H N N 258 
MET HG2  H N N 259 
MET HG3  H N N 260 
MET HE1  H N N 261 
MET HE2  H N N 262 
MET HE3  H N N 263 
MET HXT  H N N 264 
PHE N    N N N 265 
PHE CA   C N S 266 
PHE C    C N N 267 
PHE O    O N N 268 
PHE CB   C N N 269 
PHE CG   C Y N 270 
PHE CD1  C Y N 271 
PHE CD2  C Y N 272 
PHE CE1  C Y N 273 
PHE CE2  C Y N 274 
PHE CZ   C Y N 275 
PHE OXT  O N N 276 
PHE H    H N N 277 
PHE H2   H N N 278 
PHE HA   H N N 279 
PHE HB2  H N N 280 
PHE HB3  H N N 281 
PHE HD1  H N N 282 
PHE HD2  H N N 283 
PHE HE1  H N N 284 
PHE HE2  H N N 285 
PHE HZ   H N N 286 
PHE HXT  H N N 287 
PRO N    N N N 288 
PRO CA   C N S 289 
PRO C    C N N 290 
PRO O    O N N 291 
PRO CB   C N N 292 
PRO CG   C N N 293 
PRO CD   C N N 294 
PRO OXT  O N N 295 
PRO H    H N N 296 
PRO HA   H N N 297 
PRO HB2  H N N 298 
PRO HB3  H N N 299 
PRO HG2  H N N 300 
PRO HG3  H N N 301 
PRO HD2  H N N 302 
PRO HD3  H N N 303 
PRO HXT  H N N 304 
SEP N    N N N 305 
SEP CA   C N S 306 
SEP CB   C N N 307 
SEP OG   O N N 308 
SEP C    C N N 309 
SEP O    O N N 310 
SEP OXT  O N N 311 
SEP P    P N N 312 
SEP O1P  O N N 313 
SEP O2P  O N N 314 
SEP O3P  O N N 315 
SEP H    H N N 316 
SEP H2   H N N 317 
SEP HA   H N N 318 
SEP HB2  H N N 319 
SEP HB3  H N N 320 
SEP HXT  H N N 321 
SEP HOP2 H N N 322 
SEP HOP3 H N N 323 
SER N    N N N 324 
SER CA   C N S 325 
SER C    C N N 326 
SER O    O N N 327 
SER CB   C N N 328 
SER OG   O N N 329 
SER OXT  O N N 330 
SER H    H N N 331 
SER H2   H N N 332 
SER HA   H N N 333 
SER HB2  H N N 334 
SER HB3  H N N 335 
SER HG   H N N 336 
SER HXT  H N N 337 
THR N    N N N 338 
THR CA   C N S 339 
THR C    C N N 340 
THR O    O N N 341 
THR CB   C N R 342 
THR OG1  O N N 343 
THR CG2  C N N 344 
THR OXT  O N N 345 
THR H    H N N 346 
THR H2   H N N 347 
THR HA   H N N 348 
THR HB   H N N 349 
THR HG1  H N N 350 
THR HG21 H N N 351 
THR HG22 H N N 352 
THR HG23 H N N 353 
THR HXT  H N N 354 
TRP N    N N N 355 
TRP CA   C N S 356 
TRP C    C N N 357 
TRP O    O N N 358 
TRP CB   C N N 359 
TRP CG   C Y N 360 
TRP CD1  C Y N 361 
TRP CD2  C Y N 362 
TRP NE1  N Y N 363 
TRP CE2  C Y N 364 
TRP CE3  C Y N 365 
TRP CZ2  C Y N 366 
TRP CZ3  C Y N 367 
TRP CH2  C Y N 368 
TRP OXT  O N N 369 
TRP H    H N N 370 
TRP H2   H N N 371 
TRP HA   H N N 372 
TRP HB2  H N N 373 
TRP HB3  H N N 374 
TRP HD1  H N N 375 
TRP HE1  H N N 376 
TRP HE3  H N N 377 
TRP HZ2  H N N 378 
TRP HZ3  H N N 379 
TRP HH2  H N N 380 
TRP HXT  H N N 381 
TYR N    N N N 382 
TYR CA   C N S 383 
TYR C    C N N 384 
TYR O    O N N 385 
TYR CB   C N N 386 
TYR CG   C Y N 387 
TYR CD1  C Y N 388 
TYR CD2  C Y N 389 
TYR CE1  C Y N 390 
TYR CE2  C Y N 391 
TYR CZ   C Y N 392 
TYR OH   O N N 393 
TYR OXT  O N N 394 
TYR H    H N N 395 
TYR H2   H N N 396 
TYR HA   H N N 397 
TYR HB2  H N N 398 
TYR HB3  H N N 399 
TYR HD1  H N N 400 
TYR HD2  H N N 401 
TYR HE1  H N N 402 
TYR HE2  H N N 403 
TYR HH   H N N 404 
TYR HXT  H N N 405 
VAL N    N N N 406 
VAL CA   C N S 407 
VAL C    C N N 408 
VAL O    O N N 409 
VAL CB   C N N 410 
VAL CG1  C N N 411 
VAL CG2  C N N 412 
VAL OXT  O N N 413 
VAL H    H N N 414 
VAL H2   H N N 415 
VAL HA   H N N 416 
VAL HB   H N N 417 
VAL HG11 H N N 418 
VAL HG12 H N N 419 
VAL HG13 H N N 420 
VAL HG21 H N N 421 
VAL HG22 H N N 422 
VAL HG23 H N N 423 
VAL HXT  H N N 424 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CSO N   CA   sing N N 70  
CSO N   H    sing N N 71  
CSO N   H2   sing N N 72  
CSO CA  CB   sing N N 73  
CSO CA  C    sing N N 74  
CSO CA  HA   sing N N 75  
CSO CB  SG   sing N N 76  
CSO CB  HB2  sing N N 77  
CSO CB  HB3  sing N N 78  
CSO SG  OD   sing N N 79  
CSO C   O    doub N N 80  
CSO C   OXT  sing N N 81  
CSO OXT HXT  sing N N 82  
CSO OD  HD   sing N N 83  
CYS N   CA   sing N N 84  
CYS N   H    sing N N 85  
CYS N   H2   sing N N 86  
CYS CA  C    sing N N 87  
CYS CA  CB   sing N N 88  
CYS CA  HA   sing N N 89  
CYS C   O    doub N N 90  
CYS C   OXT  sing N N 91  
CYS CB  SG   sing N N 92  
CYS CB  HB2  sing N N 93  
CYS CB  HB3  sing N N 94  
CYS SG  HG   sing N N 95  
CYS OXT HXT  sing N N 96  
GLN N   CA   sing N N 97  
GLN N   H    sing N N 98  
GLN N   H2   sing N N 99  
GLN CA  C    sing N N 100 
GLN CA  CB   sing N N 101 
GLN CA  HA   sing N N 102 
GLN C   O    doub N N 103 
GLN C   OXT  sing N N 104 
GLN CB  CG   sing N N 105 
GLN CB  HB2  sing N N 106 
GLN CB  HB3  sing N N 107 
GLN CG  CD   sing N N 108 
GLN CG  HG2  sing N N 109 
GLN CG  HG3  sing N N 110 
GLN CD  OE1  doub N N 111 
GLN CD  NE2  sing N N 112 
GLN NE2 HE21 sing N N 113 
GLN NE2 HE22 sing N N 114 
GLN OXT HXT  sing N N 115 
GLU N   CA   sing N N 116 
GLU N   H    sing N N 117 
GLU N   H2   sing N N 118 
GLU CA  C    sing N N 119 
GLU CA  CB   sing N N 120 
GLU CA  HA   sing N N 121 
GLU C   O    doub N N 122 
GLU C   OXT  sing N N 123 
GLU CB  CG   sing N N 124 
GLU CB  HB2  sing N N 125 
GLU CB  HB3  sing N N 126 
GLU CG  CD   sing N N 127 
GLU CG  HG2  sing N N 128 
GLU CG  HG3  sing N N 129 
GLU CD  OE1  doub N N 130 
GLU CD  OE2  sing N N 131 
GLU OE2 HE2  sing N N 132 
GLU OXT HXT  sing N N 133 
GLY N   CA   sing N N 134 
GLY N   H    sing N N 135 
GLY N   H2   sing N N 136 
GLY CA  C    sing N N 137 
GLY CA  HA2  sing N N 138 
GLY CA  HA3  sing N N 139 
GLY C   O    doub N N 140 
GLY C   OXT  sing N N 141 
GLY OXT HXT  sing N N 142 
HIS N   CA   sing N N 143 
HIS N   H    sing N N 144 
HIS N   H2   sing N N 145 
HIS CA  C    sing N N 146 
HIS CA  CB   sing N N 147 
HIS CA  HA   sing N N 148 
HIS C   O    doub N N 149 
HIS C   OXT  sing N N 150 
HIS CB  CG   sing N N 151 
HIS CB  HB2  sing N N 152 
HIS CB  HB3  sing N N 153 
HIS CG  ND1  sing Y N 154 
HIS CG  CD2  doub Y N 155 
HIS ND1 CE1  doub Y N 156 
HIS ND1 HD1  sing N N 157 
HIS CD2 NE2  sing Y N 158 
HIS CD2 HD2  sing N N 159 
HIS CE1 NE2  sing Y N 160 
HIS CE1 HE1  sing N N 161 
HIS NE2 HE2  sing N N 162 
HIS OXT HXT  sing N N 163 
HOH O   H1   sing N N 164 
HOH O   H2   sing N N 165 
ILE N   CA   sing N N 166 
ILE N   H    sing N N 167 
ILE N   H2   sing N N 168 
ILE CA  C    sing N N 169 
ILE CA  CB   sing N N 170 
ILE CA  HA   sing N N 171 
ILE C   O    doub N N 172 
ILE C   OXT  sing N N 173 
ILE CB  CG1  sing N N 174 
ILE CB  CG2  sing N N 175 
ILE CB  HB   sing N N 176 
ILE CG1 CD1  sing N N 177 
ILE CG1 HG12 sing N N 178 
ILE CG1 HG13 sing N N 179 
ILE CG2 HG21 sing N N 180 
ILE CG2 HG22 sing N N 181 
ILE CG2 HG23 sing N N 182 
ILE CD1 HD11 sing N N 183 
ILE CD1 HD12 sing N N 184 
ILE CD1 HD13 sing N N 185 
ILE OXT HXT  sing N N 186 
LEU N   CA   sing N N 187 
LEU N   H    sing N N 188 
LEU N   H2   sing N N 189 
LEU CA  C    sing N N 190 
LEU CA  CB   sing N N 191 
LEU CA  HA   sing N N 192 
LEU C   O    doub N N 193 
LEU C   OXT  sing N N 194 
LEU CB  CG   sing N N 195 
LEU CB  HB2  sing N N 196 
LEU CB  HB3  sing N N 197 
LEU CG  CD1  sing N N 198 
LEU CG  CD2  sing N N 199 
LEU CG  HG   sing N N 200 
LEU CD1 HD11 sing N N 201 
LEU CD1 HD12 sing N N 202 
LEU CD1 HD13 sing N N 203 
LEU CD2 HD21 sing N N 204 
LEU CD2 HD22 sing N N 205 
LEU CD2 HD23 sing N N 206 
LEU OXT HXT  sing N N 207 
LYS N   CA   sing N N 208 
LYS N   H    sing N N 209 
LYS N   H2   sing N N 210 
LYS CA  C    sing N N 211 
LYS CA  CB   sing N N 212 
LYS CA  HA   sing N N 213 
LYS C   O    doub N N 214 
LYS C   OXT  sing N N 215 
LYS CB  CG   sing N N 216 
LYS CB  HB2  sing N N 217 
LYS CB  HB3  sing N N 218 
LYS CG  CD   sing N N 219 
LYS CG  HG2  sing N N 220 
LYS CG  HG3  sing N N 221 
LYS CD  CE   sing N N 222 
LYS CD  HD2  sing N N 223 
LYS CD  HD3  sing N N 224 
LYS CE  NZ   sing N N 225 
LYS CE  HE2  sing N N 226 
LYS CE  HE3  sing N N 227 
LYS NZ  HZ1  sing N N 228 
LYS NZ  HZ2  sing N N 229 
LYS NZ  HZ3  sing N N 230 
LYS OXT HXT  sing N N 231 
MET N   CA   sing N N 232 
MET N   H    sing N N 233 
MET N   H2   sing N N 234 
MET CA  C    sing N N 235 
MET CA  CB   sing N N 236 
MET CA  HA   sing N N 237 
MET C   O    doub N N 238 
MET C   OXT  sing N N 239 
MET CB  CG   sing N N 240 
MET CB  HB2  sing N N 241 
MET CB  HB3  sing N N 242 
MET CG  SD   sing N N 243 
MET CG  HG2  sing N N 244 
MET CG  HG3  sing N N 245 
MET SD  CE   sing N N 246 
MET CE  HE1  sing N N 247 
MET CE  HE2  sing N N 248 
MET CE  HE3  sing N N 249 
MET OXT HXT  sing N N 250 
PHE N   CA   sing N N 251 
PHE N   H    sing N N 252 
PHE N   H2   sing N N 253 
PHE CA  C    sing N N 254 
PHE CA  CB   sing N N 255 
PHE CA  HA   sing N N 256 
PHE C   O    doub N N 257 
PHE C   OXT  sing N N 258 
PHE CB  CG   sing N N 259 
PHE CB  HB2  sing N N 260 
PHE CB  HB3  sing N N 261 
PHE CG  CD1  doub Y N 262 
PHE CG  CD2  sing Y N 263 
PHE CD1 CE1  sing Y N 264 
PHE CD1 HD1  sing N N 265 
PHE CD2 CE2  doub Y N 266 
PHE CD2 HD2  sing N N 267 
PHE CE1 CZ   doub Y N 268 
PHE CE1 HE1  sing N N 269 
PHE CE2 CZ   sing Y N 270 
PHE CE2 HE2  sing N N 271 
PHE CZ  HZ   sing N N 272 
PHE OXT HXT  sing N N 273 
PRO N   CA   sing N N 274 
PRO N   CD   sing N N 275 
PRO N   H    sing N N 276 
PRO CA  C    sing N N 277 
PRO CA  CB   sing N N 278 
PRO CA  HA   sing N N 279 
PRO C   O    doub N N 280 
PRO C   OXT  sing N N 281 
PRO CB  CG   sing N N 282 
PRO CB  HB2  sing N N 283 
PRO CB  HB3  sing N N 284 
PRO CG  CD   sing N N 285 
PRO CG  HG2  sing N N 286 
PRO CG  HG3  sing N N 287 
PRO CD  HD2  sing N N 288 
PRO CD  HD3  sing N N 289 
PRO OXT HXT  sing N N 290 
SEP N   CA   sing N N 291 
SEP N   H    sing N N 292 
SEP N   H2   sing N N 293 
SEP CA  CB   sing N N 294 
SEP CA  C    sing N N 295 
SEP CA  HA   sing N N 296 
SEP CB  OG   sing N N 297 
SEP CB  HB2  sing N N 298 
SEP CB  HB3  sing N N 299 
SEP OG  P    sing N N 300 
SEP C   O    doub N N 301 
SEP C   OXT  sing N N 302 
SEP OXT HXT  sing N N 303 
SEP P   O1P  doub N N 304 
SEP P   O2P  sing N N 305 
SEP P   O3P  sing N N 306 
SEP O2P HOP2 sing N N 307 
SEP O3P HOP3 sing N N 308 
SER N   CA   sing N N 309 
SER N   H    sing N N 310 
SER N   H2   sing N N 311 
SER CA  C    sing N N 312 
SER CA  CB   sing N N 313 
SER CA  HA   sing N N 314 
SER C   O    doub N N 315 
SER C   OXT  sing N N 316 
SER CB  OG   sing N N 317 
SER CB  HB2  sing N N 318 
SER CB  HB3  sing N N 319 
SER OG  HG   sing N N 320 
SER OXT HXT  sing N N 321 
THR N   CA   sing N N 322 
THR N   H    sing N N 323 
THR N   H2   sing N N 324 
THR CA  C    sing N N 325 
THR CA  CB   sing N N 326 
THR CA  HA   sing N N 327 
THR C   O    doub N N 328 
THR C   OXT  sing N N 329 
THR CB  OG1  sing N N 330 
THR CB  CG2  sing N N 331 
THR CB  HB   sing N N 332 
THR OG1 HG1  sing N N 333 
THR CG2 HG21 sing N N 334 
THR CG2 HG22 sing N N 335 
THR CG2 HG23 sing N N 336 
THR OXT HXT  sing N N 337 
TRP N   CA   sing N N 338 
TRP N   H    sing N N 339 
TRP N   H2   sing N N 340 
TRP CA  C    sing N N 341 
TRP CA  CB   sing N N 342 
TRP CA  HA   sing N N 343 
TRP C   O    doub N N 344 
TRP C   OXT  sing N N 345 
TRP CB  CG   sing N N 346 
TRP CB  HB2  sing N N 347 
TRP CB  HB3  sing N N 348 
TRP CG  CD1  doub Y N 349 
TRP CG  CD2  sing Y N 350 
TRP CD1 NE1  sing Y N 351 
TRP CD1 HD1  sing N N 352 
TRP CD2 CE2  doub Y N 353 
TRP CD2 CE3  sing Y N 354 
TRP NE1 CE2  sing Y N 355 
TRP NE1 HE1  sing N N 356 
TRP CE2 CZ2  sing Y N 357 
TRP CE3 CZ3  doub Y N 358 
TRP CE3 HE3  sing N N 359 
TRP CZ2 CH2  doub Y N 360 
TRP CZ2 HZ2  sing N N 361 
TRP CZ3 CH2  sing Y N 362 
TRP CZ3 HZ3  sing N N 363 
TRP CH2 HH2  sing N N 364 
TRP OXT HXT  sing N N 365 
TYR N   CA   sing N N 366 
TYR N   H    sing N N 367 
TYR N   H2   sing N N 368 
TYR CA  C    sing N N 369 
TYR CA  CB   sing N N 370 
TYR CA  HA   sing N N 371 
TYR C   O    doub N N 372 
TYR C   OXT  sing N N 373 
TYR CB  CG   sing N N 374 
TYR CB  HB2  sing N N 375 
TYR CB  HB3  sing N N 376 
TYR CG  CD1  doub Y N 377 
TYR CG  CD2  sing Y N 378 
TYR CD1 CE1  sing Y N 379 
TYR CD1 HD1  sing N N 380 
TYR CD2 CE2  doub Y N 381 
TYR CD2 HD2  sing N N 382 
TYR CE1 CZ   doub Y N 383 
TYR CE1 HE1  sing N N 384 
TYR CE2 CZ   sing Y N 385 
TYR CE2 HE2  sing N N 386 
TYR CZ  OH   sing N N 387 
TYR OH  HH   sing N N 388 
TYR OXT HXT  sing N N 389 
VAL N   CA   sing N N 390 
VAL N   H    sing N N 391 
VAL N   H2   sing N N 392 
VAL CA  C    sing N N 393 
VAL CA  CB   sing N N 394 
VAL CA  HA   sing N N 395 
VAL C   O    doub N N 396 
VAL C   OXT  sing N N 397 
VAL CB  CG1  sing N N 398 
VAL CB  CG2  sing N N 399 
VAL CB  HB   sing N N 400 
VAL CG1 HG11 sing N N 401 
VAL CG1 HG12 sing N N 402 
VAL CG1 HG13 sing N N 403 
VAL CG2 HG21 sing N N 404 
VAL CG2 HG22 sing N N 405 
VAL CG2 HG23 sing N N 406 
VAL OXT HXT  sing N N 407 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'European Union (EU)'                                    'European Union' 101098234          1 
'Netherlands Organisation for Scientific Research (NWO)' Netherlands      VI.Veni.212.27     2 
'Other government'                                       China            'CSC 201906050031' 3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4JC3 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 2 2 21' 
_space_group.name_Hall        'C 2c 2' 
_space_group.IT_number        20 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9F35 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011795 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008677 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.015463 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG ? ? 9.41153 2.53737 ? ? 2.59044  63.03566 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P  ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . GLY A 1 1   ? 44.50897 15.42052  -4.73975  1.000 43.90565  ? -4  GLY A N    1 
ATOM   2    C CA   . GLY A 1 1   ? 44.82034 14.12582  -4.04162  1.000 85.52048  ? -4  GLY A CA   1 
ATOM   3    C C    . GLY A 1 1   ? 44.90675 12.88379  -4.92986  1.000 87.06707  ? -4  GLY A C    1 
ATOM   4    O O    . GLY A 1 1   ? 45.73355 12.81165  -5.85843  1.000 63.08262  ? -4  GLY A O    1 
ATOM   5    H H1   . GLY A 1 1   ? 45.25911 15.76730  -5.07009  1.000 52.70918  ? -4  GLY A H1   1 
ATOM   6    H H2   . GLY A 1 1   ? 43.93483 15.26941  -5.40280  1.000 52.70918  ? -4  GLY A H2   1 
ATOM   7    H H3   . GLY A 1 1   ? 44.14865 15.99120  -4.15958  1.000 52.70918  ? -4  GLY A H3   1 
ATOM   8    H HA2  . GLY A 1 1   ? 45.67404 14.21913  -3.59063  1.000 102.64698 ? -4  GLY A HA2  1 
ATOM   9    H HA3  . GLY A 1 1   ? 44.13011 13.96126  -3.38025  1.000 102.64698 ? -4  GLY A HA3  1 
ATOM   10   N N    . ALA A 1 2   ? 44.05013 11.89347  -4.63807  1.000 77.76821  ? -3  ALA A N    1 
ATOM   11   C CA   . ALA A 1 2   ? 43.99958 10.67242  -5.44081  1.000 61.69944  ? -3  ALA A CA   1 
ATOM   12   C C    . ALA A 1 2   ? 43.56519 10.93135  -6.87947  1.000 70.13364  ? -3  ALA A C    1 
ATOM   13   O O    . ALA A 1 2   ? 43.88193 10.11721  -7.76105  1.000 39.89490  ? -3  ALA A O    1 
ATOM   14   C CB   . ALA A 1 2   ? 43.03623 9.65596   -4.81745  1.000 52.39382  ? -3  ALA A CB   1 
ATOM   15   H H    . ALA A 1 2   ? 43.49246 11.90745  -3.98354  1.000 93.34425  ? -3  ALA A H    1 
ATOM   16   H HA   . ALA A 1 2   ? 44.89216 10.29276  -5.44867  1.000 74.06172  ? -3  ALA A HA   1 
ATOM   17   H HB1  . ALA A 1 2   ? 42.14491 10.03799  -4.79538  1.000 62.89498  ? -3  ALA A HB1  1 
ATOM   18   H HB2  . ALA A 1 2   ? 43.03699 8.84895   -5.35563  1.000 62.89498  ? -3  ALA A HB2  1 
ATOM   19   H HB3  . ALA A 1 2   ? 43.33142 9.45272   -3.91609  1.000 62.89498  ? -3  ALA A HB3  1 
ATOM   20   N N    . MET A 1 3   ? 42.87029 12.05307  -7.12548  1.000 64.85230  ? -2  MET A N    1 
ATOM   21   C CA   . MET A 1 3   ? 42.14943 12.34141  -8.36424  1.000 41.87162  ? -2  MET A CA   1 
ATOM   22   C C    . MET A 1 3   ? 42.83808 13.41350  -9.18671  1.000 32.39646  ? -2  MET A C    1 
ATOM   23   O O    . MET A 1 3   ? 42.18745 14.12189  -9.97151  1.000 18.95309  ? -2  MET A O    1 
ATOM   24   C CB   . MET A 1 3   ? 40.72662 12.77384  -8.02867  1.000 37.31218  ? -2  MET A CB   1 
ATOM   25   C CG   . MET A 1 3   ? 39.90598 11.68356  -7.41310  1.000 34.19979  ? -2  MET A CG   1 
ATOM   26   S SD   . MET A 1 3   ? 39.55608 10.39476  -8.58790  1.000 32.36012  ? -2  MET A SD   1 
ATOM   27   C CE   . MET A 1 3   ? 37.92622 9.97333   -8.06862  1.000 37.17693  ? -2  MET A CE   1 
ATOM   28   H H    . MET A 1 3   ? 42.80113 12.69352  -6.55572  1.000 77.84516  ? -2  MET A H    1 
ATOM   29   H HA   . MET A 1 3   ? 42.10749 11.53234  -8.89767  1.000 50.26835  ? -2  MET A HA   1 
ATOM   30   H HB2  . MET A 1 3   ? 40.76315 13.51100  -7.39926  1.000 44.79701  ? -2  MET A HB2  1 
ATOM   31   H HB3  . MET A 1 3   ? 40.28394 13.05575  -8.84443  1.000 44.79701  ? -2  MET A HB3  1 
ATOM   32   H HG2  . MET A 1 3   ? 40.39294 11.29556  -6.66931  1.000 41.06215  ? -2  MET A HG2  1 
ATOM   33   H HG3  . MET A 1 3   ? 39.06384 12.05133  -7.10256  1.000 41.06215  ? -2  MET A HG3  1 
ATOM   34   H HE1  . MET A 1 3   ? 37.55178 9.33218   -8.69282  1.000 44.63472  ? -2  MET A HE1  1 
ATOM   35   H HE2  . MET A 1 3   ? 37.96817 9.58490   -7.18078  1.000 44.63472  ? -2  MET A HE2  1 
ATOM   36   H HE3  . MET A 1 3   ? 37.38222 10.77628  -8.05302  1.000 44.63472  ? -2  MET A HE3  1 
ATOM   37   N N    . GLY A 1 4   ? 44.13478 13.56502  -9.00115  1.000 33.34414  ? -1  GLY A N    1 
ATOM   38   C CA   . GLY A 1 4   ? 44.82164 14.73633  -9.47637  1.000 31.29801  ? -1  GLY A CA   1 
ATOM   39   C C    . GLY A 1 4   ? 45.11720 14.75412  -10.94368 1.000 20.92320  ? -1  GLY A C    1 
ATOM   40   O O    . GLY A 1 4   ? 45.46457 15.81877  -11.45175 1.000 29.27232  ? -1  GLY A O    1 
ATOM   41   H H    . GLY A 1 4   ? 44.63993 12.99684  -8.59916  1.000 40.03537  ? -1  GLY A H    1 
ATOM   42   H HA2  . GLY A 1 4   ? 44.27872 15.51492  -9.27653  1.000 37.58001  ? -1  GLY A HA2  1 
ATOM   43   H HA3  . GLY A 1 4   ? 45.66641 14.81111  -9.00554  1.000 37.58001  ? -1  GLY A HA3  1 
ATOM   44   N N    . SER A 1 5   ? 45.01358 13.60254  -11.62392 1.000 25.66076  ? 0   SER A N    1 
ATOM   45   C CA   . SER A 1 5   ? 45.23947 13.48961  -13.06605 1.000 23.94420  ? 0   SER A CA   1 
ATOM   46   C C    . SER A 1 5   ? 44.00920 13.78927  -13.92079 1.000 13.31663  ? 0   SER A C    1 
ATOM   47   O O    . SER A 1 5   ? 44.13425 13.84673  -15.13694 1.000 26.35942  ? 0   SER A O    1 
ATOM   48   C CB   . SER A 1 5   ? 45.73362 12.07994  -13.40482 1.000 26.88358  ? 0   SER A CB   1 
ATOM   49   O OG   . SER A 1 5   ? 47.13563 12.02840  -13.25536 1.000 39.42583  ? 0   SER A OG   1 
ATOM   50   H H    . SER A 1 5   ? 44.80719 12.85204  -11.25820 1.000 30.81532  ? 0   SER A H    1 
ATOM   51   H HA   . SER A 1 5   ? 45.92309 14.13399  -13.30759 1.000 28.75544  ? 0   SER A HA   1 
ATOM   52   H HB2  . SER A 1 5   ? 45.32200 11.44109  -12.80204 1.000 32.28270  ? 0   SER A HB2  1 
ATOM   53   H HB3  . SER A 1 5   ? 45.49978 11.86874  -14.32222 1.000 32.28270  ? 0   SER A HB3  1 
ATOM   54   H HG   . SER A 1 5   ? 47.42288 11.27693  -13.49697 1.000 47.33340  ? 0   SER A HG   1 
ATOM   55   N N    . MET A 1 6   ? 42.84322 14.01194  -13.32722 1.000 19.67173  ? 1   MET A N    1 
ATOM   56   C CA   . MET A 1 6   ? 41.58626 14.14361  -14.03237 1.000 16.60158  ? 1   MET A CA   1 
ATOM   57   C C    . MET A 1 6   ? 41.10992 15.58647  -14.01824 1.000 12.29887  ? 1   MET A C    1 
ATOM   58   O O    . MET A 1 6   ? 41.27665 16.29285  -13.02574 1.000 19.71078  ? 1   MET A O    1 
ATOM   59   C CB   . MET A 1 6   ? 40.52884 13.24668  -13.37288 1.000 14.82033  ? 1   MET A CB   1 
ATOM   60   C CG   . MET A 1 6   ? 39.76450 12.33575  -14.38890 1.000 40.15870  ? 1   MET A CG   1 
ATOM   61   S SD   . MET A 1 6   ? 38.10168 11.74998  -13.90693 1.000 25.81130  ? 1   MET A SD   1 
ATOM   62   C CE   . MET A 1 6   ? 38.66106 10.64525  -12.60361 1.000 24.56848  ? 1   MET A CE   1 
ATOM   63   H H    . MET A 1 6   ? 42.75578 14.09366  -12.47559 1.000 23.62848  ? 1   MET A H    1 
ATOM   64   H HA   . MET A 1 6   ? 41.70266 13.87366  -14.95675 1.000 19.94430  ? 1   MET A HA   1 
ATOM   65   H HB2  . MET A 1 6   ? 40.96620 12.67011  -12.72699 1.000 17.80680  ? 1   MET A HB2  1 
ATOM   66   H HB3  . MET A 1 6   ? 39.87566 13.80853  -12.92726 1.000 17.80680  ? 1   MET A HB3  1 
ATOM   67   H HG2  . MET A 1 6   ? 39.65750 12.83417  -15.21414 1.000 48.21284  ? 1   MET A HG2  1 
ATOM   68   H HG3  . MET A 1 6   ? 40.30499 11.54579  -14.54612 1.000 48.21284  ? 1   MET A HG3  1 
ATOM   69   H HE1  . MET A 1 6   ? 37.89184 10.19945  -12.21572 1.000 29.50458  ? 1   MET A HE1  1 
ATOM   70   H HE2  . MET A 1 6   ? 39.26653 9.98958   -12.98363 1.000 29.50458  ? 1   MET A HE2  1 
ATOM   71   H HE3  . MET A 1 6   ? 39.11961 11.16453  -11.92465 1.000 29.50458  ? 1   MET A HE3  1 
ATOM   72   N N    . GLU A 1 7   ? 40.46240 15.99612  -15.11903 1.000 6.04020   ? 2   GLU A N    1 
ATOM   73   C CA   . GLU A 1 7   ? 39.99340 17.37018  -15.25539 1.000 22.18776  ? 2   GLU A CA   1 
ATOM   74   C C    . GLU A 1 7   ? 38.85136 17.64511  -14.28332 1.000 29.52936  ? 2   GLU A C    1 
ATOM   75   O O    . GLU A 1 7   ? 38.03962 16.76937  -13.98418 1.000 24.99413  ? 2   GLU A O    1 
ATOM   76   C CB   . GLU A 1 7   ? 39.47838 17.66359  -16.66679 1.000 25.94610  ? 2   GLU A CB   1 
ATOM   77   C CG   . GLU A 1 7   ? 40.48058 17.66970  -17.77590 1.000 25.29671  ? 2   GLU A CG   1 
ATOM   78   C CD   . GLU A 1 7   ? 41.13583 18.99777  -17.95237 1.000 15.89399  ? 2   GLU A CD   1 
ATOM   79   O OE1  . GLU A 1 7   ? 41.10679 19.80654  -17.00559 1.000 26.51323  ? 2   GLU A OE1  1 
ATOM   80   O OE2  . GLU A 1 7   ? 41.71044 19.23766  -19.02865 1.000 28.82728  ? 2   GLU A OE2  1 
ATOM   81   H H    . GLU A 1 7   ? 40.28564 15.49525  -15.79540 1.000 7.27064   ? 2   GLU A H    1 
ATOM   82   H HA   . GLU A 1 7   ? 40.74469 17.95547  -15.07126 1.000 26.64771  ? 2   GLU A HA   1 
ATOM   83   H HB2  . GLU A 1 7   ? 38.81790 16.98886  -16.88903 1.000 31.15773  ? 2   GLU A HB2  1 
ATOM   84   H HB3  . GLU A 1 7   ? 39.06557 18.54130  -16.65668 1.000 31.15773  ? 2   GLU A HB3  1 
ATOM   85   H HG2  . GLU A 1 7   ? 41.17171 17.01750  -17.58129 1.000 30.37845  ? 2   GLU A HG2  1 
ATOM   86   H HG3  . GLU A 1 7   ? 40.03438 17.44240  -18.60664 1.000 30.37845  ? 2   GLU A HG3  1 
ATOM   87   N N    . ARG A 1 8   ? 38.75816 18.90074  -13.83931 1.000 32.35585  ? 3   ARG A N    1 
ATOM   88   C CA   . ARG A 1 8   ? 37.70980 19.26265  -12.88516 1.000 29.62366  ? 3   ARG A CA   1 
ATOM   89   C C    . ARG A 1 8   ? 36.32941 18.92522  -13.43626 1.000 32.12260  ? 3   ARG A C    1 
ATOM   90   O O    . ARG A 1 8   ? 35.45307 18.45261  -12.70084 1.000 28.63532  ? 3   ARG A O    1 
ATOM   91   C CB   . ARG A 1 8   ? 37.81285 20.75386  -12.53986 1.000 22.55779  ? 3   ARG A CB   1 
ATOM   92   C CG   . ARG A 1 8   ? 36.72842 21.30277  -11.62892 1.000 11.78128  ? 3   ARG A CG   1 
ATOM   93   C CD   . ARG A 1 8   ? 36.99417 22.77081  -11.27399 1.000 19.23553  ? 3   ARG A CD   1 
ATOM   94   N NE   . ARG A 1 8   ? 36.20722 23.25044  -10.13969 1.000 22.63431  ? 3   ARG A NE   1 
ATOM   95   C CZ   . ARG A 1 8   ? 34.90969 23.53311  -10.19628 1.000 11.28103  ? 3   ARG A CZ   1 
ATOM   96   N NH1  . ARG A 1 8   ? 34.23129 23.37838  -11.30643 1.000 16.34234  ? 3   ARG A NH1  1 
ATOM   97   N NH2  . ARG A 1 8   ? 34.26964 23.92217  -9.08389  1.000 23.24162  ? 3   ARG A NH2  1 
ATOM   98   H H    . ARG A 1 8   ? 39.27709 19.54681  -14.06933 1.000 38.84943  ? 3   ARG A H    1 
ATOM   99   H HA   . ARG A 1 8   ? 37.83463 18.75803  -12.06621 1.000 35.57079  ? 3   ARG A HA   1 
ATOM   100  H HB2  . ARG A 1 8   ? 38.66253 20.90436  -12.09682 1.000 27.09175  ? 3   ARG A HB2  1 
ATOM   101  H HB3  . ARG A 1 8   ? 37.77565 21.25969  -13.36670 1.000 27.09175  ? 3   ARG A HB3  1 
ATOM   102  H HG2  . ARG A 1 8   ? 35.87067 21.24678  -12.07840 1.000 14.15994  ? 3   ARG A HG2  1 
ATOM   103  H HG3  . ARG A 1 8   ? 36.70649 20.78809  -10.80701 1.000 14.15994  ? 3   ARG A HG3  1 
ATOM   104  H HD2  . ARG A 1 8   ? 37.93195 22.87346  -11.04832 1.000 23.10503  ? 3   ARG A HD2  1 
ATOM   105  H HD3  . ARG A 1 8   ? 36.77513 23.32286  -12.04091 1.000 23.10503  ? 3   ARG A HD3  1 
ATOM   106  H HE   . ARG A 1 8   ? 36.60962 23.35661  -9.38709  1.000 27.18358  ? 3   ARG A HE   1 
ATOM   107  H HH11 . ARG A 1 8   ? 34.62510 23.08959  -12.01432 1.000 19.63321  ? 3   ARG A HH11 1 
ATOM   108  H HH12 . ARG A 1 8   ? 33.39217 23.56560  -11.32723 1.000 19.63321  ? 3   ARG A HH12 1 
ATOM   109  H HH21 . ARG A 1 8   ? 34.69865 23.98717  -8.34138  1.000 27.91235  ? 3   ARG A HH21 1 
ATOM   110  H HH22 . ARG A 1 8   ? 33.43017 24.10669  -9.11305  1.000 27.91235  ? 3   ARG A HH22 1 
ATOM   111  N N    . ALA A 1 9   ? 36.11410 19.14150  -14.72531 1.000 23.75041  ? 4   ALA A N    1 
ATOM   112  C CA   . ALA A 1 9   ? 34.76835 18.96161  -15.24816 1.000 24.41309  ? 4   ALA A CA   1 
ATOM   113  C C    . ALA A 1 9   ? 34.40769 17.48925  -15.41005 1.000 26.70195  ? 4   ALA A C    1 
ATOM   114  O O    . ALA A 1 9   ? 33.28983 17.08465  -15.06537 1.000 18.09127  ? 4   ALA A O    1 
ATOM   115  C CB   . ALA A 1 9   ? 34.64597 19.70572  -16.56770 1.000 22.37608  ? 4   ALA A CB   1 
ATOM   116  H H    . ALA A 1 9   ? 36.70758 19.38422  -15.29843 1.000 28.52289  ? 4   ALA A H    1 
ATOM   117  H HA   . ALA A 1 9   ? 34.12809 19.33815  -14.62432 1.000 29.31810  ? 4   ALA A HA   1 
ATOM   118  H HB1  . ALA A 1 9   ? 34.89096 20.63420  -16.43057 1.000 26.87369  ? 4   ALA A HB1  1 
ATOM   119  H HB2  . ALA A 1 9   ? 35.24160 19.29877  -17.21617 1.000 26.87369  ? 4   ALA A HB2  1 
ATOM   120  H HB3  . ALA A 1 9   ? 33.72906 19.64805  -16.87892 1.000 26.87369  ? 4   ALA A HB3  1 
ATOM   121  N N    . SER A 1 10  ? 35.33642 16.66519  -15.90859 1.000 18.71553  ? 5   SER A N    1 
ATOM   122  C CA   . SER A 1 10  ? 35.12136 15.21435  -15.88522 1.000 15.20746  ? 5   SER A CA   1 
ATOM   123  C C    . SER A 1 10  ? 34.76841 14.69892  -14.47374 1.000 21.23274  ? 5   SER A C    1 
ATOM   124  O O    . SER A 1 10  ? 33.96095 13.76881  -14.33203 1.000 12.30405  ? 5   SER A O    1 
ATOM   125  C CB   . SER A 1 10  ? 36.35516 14.49699  -16.39216 1.000 11.74415  ? 5   SER A CB   1 
ATOM   126  O OG   . SER A 1 10  ? 36.91145 15.11177  -17.53334 1.000 17.01824  ? 5   SER A OG   1 
ATOM   127  H H    . SER A 1 10  ? 36.08189 16.91421  -16.25770 1.000 22.48104  ? 5   SER A H    1 
ATOM   128  H HA   . SER A 1 10  ? 34.37895 15.01012  -16.47514 1.000 18.27136  ? 5   SER A HA   1 
ATOM   129  H HB2  . SER A 1 10  ? 37.02172 14.49438  -15.68747 1.000 14.11538  ? 5   SER A HB2  1 
ATOM   130  H HB3  . SER A 1 10  ? 36.11046 13.58661  -16.62073 1.000 14.11538  ? 5   SER A HB3  1 
ATOM   131  H HG   . SER A 1 10  ? 36.43311 14.95539  -18.20589 1.000 20.44429  ? 5   SER A HG   1 
ATOM   132  N N    . LEU A 1 11  ? 35.34448 15.29669  -13.42596 1.000 32.89973  ? 6   LEU A N    1 
ATOM   133  C CA   . LEU A 1 11  ? 35.01978 14.87677  -12.06023 1.000 10.97807  ? 6   LEU A CA   1 
ATOM   134  C C    . LEU A 1 11  ? 33.56911 15.23270  -11.70624 1.000 20.48233  ? 6   LEU A C    1 
ATOM   135  O O    . LEU A 1 11  ? 32.82587 14.38386  -11.19070 1.000 14.59416  ? 6   LEU A O    1 
ATOM   136  C CB   . LEU A 1 11  ? 36.02317 15.48985  -11.06918 1.000 12.63028  ? 6   LEU A CB   1 
ATOM   137  C CG   . LEU A 1 11  ? 37.44091 14.90841  -11.01333 1.000 16.84429  ? 6   LEU A CG   1 
ATOM   138  C CD1  . LEU A 1 11  ? 38.44796 15.97739  -10.60574 1.000 12.54141  ? 6   LEU A CD1  1 
ATOM   139  C CD2  . LEU A 1 11  ? 37.61114 13.76494  -10.02420 1.000 36.17487  ? 6   LEU A CD2  1 
ATOM   140  H H    . LEU A 1 11  ? 35.91661 15.93670  -13.47753 1.000 39.50208  ? 6   LEU A H    1 
ATOM   141  H HA   . LEU A 1 11  ? 35.10343 13.91291  -11.99041 1.000 13.19609  ? 6   LEU A HA   1 
ATOM   142  H HB2  . LEU A 1 11  ? 36.11783 16.42924  -11.29161 1.000 15.17873  ? 6   LEU A HB2  1 
ATOM   143  H HB3  . LEU A 1 11  ? 35.65013 15.39571  -10.17874 1.000 15.17873  ? 6   LEU A HB3  1 
ATOM   144  H HG   . LEU A 1 11  ? 37.60479 14.57041  -11.90765 1.000 20.23555  ? 6   LEU A HG   1 
ATOM   145  H HD11 . LEU A 1 11  ? 38.12212 16.43257  -9.81357  1.000 15.07210  ? 6   LEU A HD11 1 
ATOM   146  H HD12 . LEU A 1 11  ? 39.29962 15.55328  -10.41677 1.000 15.07210  ? 6   LEU A HD12 1 
ATOM   147  H HD13 . LEU A 1 11  ? 38.54812 16.61079  -11.33352 1.000 15.07210  ? 6   LEU A HD13 1 
ATOM   148  H HD21 . LEU A 1 11  ? 36.87606 13.14142  -10.13274 1.000 43.43225  ? 6   LEU A HD21 1 
ATOM   149  H HD22 . LEU A 1 11  ? 38.45338 13.31734  -10.20084 1.000 43.43225  ? 6   LEU A HD22 1 
ATOM   150  H HD23 . LEU A 1 11  ? 37.61000 14.12402  -9.12312  1.000 43.43225  ? 6   LEU A HD23 1 
ATOM   151  N N    . ILE A 1 12  ? 33.13088 16.46625  -12.00470 1.000 34.36626  ? 7   ILE A N    1 
ATOM   152  C CA   . ILE A 1 12  ? 31.70840 16.80894  -11.83160 1.000 22.61394  ? 7   ILE A CA   1 
ATOM   153  C C    . ILE A 1 12  ? 30.87046 15.84527  -12.63838 1.000 22.48937  ? 7   ILE A C    1 
ATOM   154  O O    . ILE A 1 12  ? 29.86304 15.32430  -12.14737 1.000 19.71483  ? 7   ILE A O    1 
ATOM   155  C CB   . ILE A 1 12  ? 31.41097 18.26676  -12.24641 1.000 19.17789  ? 7   ILE A CB   1 
ATOM   156  C CG1  . ILE A 1 12  ? 32.30875 19.24574  -11.49541 1.000 28.09490  ? 7   ILE A CG1  1 
ATOM   157  C CG2  . ILE A 1 12  ? 29.92569 18.69677  -11.96965 1.000 10.74670  ? 7   ILE A CG2  1 
ATOM   158  C CD1  . ILE A 1 12  ? 32.25350 19.05527  -10.01555 1.000 13.73489  ? 7   ILE A CD1  1 
ATOM   159  H H    . ILE A 1 12  ? 33.62256 17.10654  -12.30116 1.000 41.26191  ? 7   ILE A H    1 
ATOM   160  H HA   . ILE A 1 12  ? 31.49325 16.73255  -10.88885 1.000 27.15913  ? 7   ILE A HA   1 
ATOM   161  H HB   . ILE A 1 12  ? 31.58042 18.29314  -13.20113 1.000 23.03587  ? 7   ILE A HB   1 
ATOM   162  H HG12 . ILE A 1 12  ? 33.22658 19.11660  -11.78145 1.000 33.73628  ? 7   ILE A HG12 1 
ATOM   163  H HG13 . ILE A 1 12  ? 32.02399 20.15168  -11.69313 1.000 33.73628  ? 7   ILE A HG13 1 
ATOM   164  H HG21 . ILE A 1 12  ? 29.83785 19.64954  -12.12902 1.000 12.91845  ? 7   ILE A HG21 1 
ATOM   165  H HG22 . ILE A 1 12  ? 29.33856 18.20615  -12.56586 1.000 12.91845  ? 7   ILE A HG22 1 
ATOM   166  H HG23 . ILE A 1 12  ? 29.70488 18.49396  -11.04715 1.000 12.91845  ? 7   ILE A HG23 1 
ATOM   167  H HD11 . ILE A 1 12  ? 31.32578 19.04919  -9.73235  1.000 16.50427  ? 7   ILE A HD11 1 
ATOM   168  H HD12 . ILE A 1 12  ? 32.67376 18.21066  -9.78994  1.000 16.50427  ? 7   ILE A HD12 1 
ATOM   169  H HD13 . ILE A 1 12  ? 32.72589 19.78512  -9.58535  1.000 16.50427  ? 7   ILE A HD13 1 
ATOM   170  N N    . GLN A 1 13  ? 31.32554 15.54647  -13.87271 1.000 11.99267  ? 8   GLN A N    1 
ATOM   171  C CA   . GLN A 1 13  ? 30.55122 14.72470  -14.79696 1.000 12.19114  ? 8   GLN A CA   1 
ATOM   172  C C    . GLN A 1 13  ? 30.29400 13.33712  -14.21680 1.000 11.59298  ? 8   GLN A C    1 
ATOM   173  O O    . GLN A 1 13  ? 29.16422 12.83247  -14.25875 1.000 14.45943  ? 8   GLN A O    1 
ATOM   174  C CB   . GLN A 1 13  ? 31.28688 14.62453  -16.13876 1.000 23.64485  ? 8   GLN A CB   1 
ATOM   175  C CG   . GLN A 1 13  ? 30.40842 14.23570  -17.33061 1.000 29.04543  ? 8   GLN A CG   1 
ATOM   176  C CD   . GLN A 1 13  ? 31.09224 14.44565  -18.73998 1.000 61.41755  ? 8   GLN A CD   1 
ATOM   177  O OE1  . GLN A 1 13  ? 31.90426 15.37840  -18.96855 1.000 39.20956  ? 8   GLN A OE1  1 
ATOM   178  N NE2  . GLN A 1 13  ? 30.72726 13.57270  -19.68884 1.000 25.73991  ? 8   GLN A NE2  1 
ATOM   179  H H    . GLN A 1 13  ? 32.07962 15.81121  -14.19034 1.000 14.41360  ? 8   GLN A H    1 
ATOM   180  H HA   . GLN A 1 13  ? 29.69163 15.14681  -14.95130 1.000 14.65177  ? 8   GLN A HA   1 
ATOM   181  H HB2  . GLN A 1 13  ? 31.68145 15.48803  -16.33773 1.000 28.39622  ? 8   GLN A HB2  1 
ATOM   182  H HB3  . GLN A 1 13  ? 31.98197 13.95276  -16.05836 1.000 28.39622  ? 8   GLN A HB3  1 
ATOM   183  H HG2  . GLN A 1 13  ? 30.17890 13.29644  -17.25313 1.000 34.87691  ? 8   GLN A HG2  1 
ATOM   184  H HG3  . GLN A 1 13  ? 29.60343 14.77657  -17.31186 1.000 34.87691  ? 8   GLN A HG3  1 
ATOM   185  H HE21 . GLN A 1 13  ? 30.15797 12.95402  -19.50792 1.000 30.91029  ? 8   GLN A HE21 1 
ATOM   186  H HE22 . GLN A 1 13  ? 31.06232 13.63114  -20.47873 1.000 30.91029  ? 8   GLN A HE22 1 
ATOM   187  N N    . LYS A 1 14  ? 31.34110 12.70262  -13.66382 1.000 25.43945  ? 9   LYS A N    1 
ATOM   188  C CA   . LYS A 1 14  ? 31.23111 11.35350  -13.10418 1.000 13.67055  ? 9   LYS A CA   1 
ATOM   189  C C    . LYS A 1 14  ? 30.51155 11.31535  -11.74951 1.000 14.52878  ? 9   LYS A C    1 
ATOM   190  O O    . LYS A 1 14  ? 29.95633 10.27961  -11.38873 1.000 24.90171  ? 9   LYS A O    1 
ATOM   191  C CB   . LYS A 1 14  ? 32.64114 10.74774  -13.01718 1.000 16.78746  ? 9   LYS A CB   1 
ATOM   192  C CG   . LYS A 1 14  ? 33.27645 10.49464  -14.42763 1.000 10.17874  ? 9   LYS A CG   1 
ATOM   193  C CD   . LYS A 1 14  ? 34.36178 9.45970   -14.44948 1.000 15.38888  ? 9   LYS A CD   1 
ATOM   194  C CE   . LYS A 1 14  ? 35.45567 9.81496   -15.42878 1.000 29.08520  ? 9   LYS A CE   1 
ATOM   195  N NZ   . LYS A 1 14  ? 36.48580 8.75202   -15.49046 1.000 43.93246  ? 9   LYS A NZ   1 
ATOM   196  H H    . LYS A 1 14  ? 32.13067 13.03778  -13.60183 1.000 30.54974  ? 9   LYS A H    1 
ATOM   197  H HA   . LYS A 1 14  ? 30.70165 10.79086  -13.69071 1.000 16.42706  ? 9   LYS A HA   1 
ATOM   198  H HB2  . LYS A 1 14  ? 33.21822 11.35828  -12.53229 1.000 20.16736  ? 9   LYS A HB2  1 
ATOM   199  H HB3  . LYS A 1 14  ? 32.59204 9.89783   -12.55227 1.000 20.16736  ? 9   LYS A HB3  1 
ATOM   200  H HG2  . LYS A 1 14  ? 32.57847 10.19747  -15.03213 1.000 12.23689  ? 9   LYS A HG2  1 
ATOM   201  H HG3  . LYS A 1 14  ? 33.66040 11.32607  -14.74733 1.000 12.23689  ? 9   LYS A HG3  1 
ATOM   202  H HD2  . LYS A 1 14  ? 34.75599 9.39042   -13.56591 1.000 18.48906  ? 9   LYS A HD2  1 
ATOM   203  H HD3  . LYS A 1 14  ? 33.98454 8.60560   -14.71235 1.000 18.48906  ? 9   LYS A HD3  1 
ATOM   204  H HE2  . LYS A 1 14  ? 35.07339 9.92269   -16.31375 1.000 34.92465  ? 9   LYS A HE2  1 
ATOM   205  H HE3  . LYS A 1 14  ? 35.88297 10.63971  -15.14933 1.000 34.92465  ? 9   LYS A HE3  1 
ATOM   206  H HZ1  . LYS A 1 14  ? 37.14496 8.99820   -16.03543 1.000 52.74136  ? 9   LYS A HZ1  1 
ATOM   207  H HZ2  . LYS A 1 14  ? 36.82120 8.60573   -14.67916 1.000 52.74136  ? 9   LYS A HZ2  1 
ATOM   208  H HZ3  . LYS A 1 14  ? 36.12621 7.99693   -15.79481 1.000 52.74136  ? 9   LYS A HZ3  1 
ATOM   209  N N    . ALA A 1 15  ? 30.46992 12.42001  -11.00175 1.000 12.72173  ? 10  ALA A N    1 
ATOM   210  C CA   . ALA A 1 15  ? 29.69145 12.42919  -9.76450  1.000 15.76003  ? 10  ALA A CA   1 
ATOM   211  C C    . ALA A 1 15  ? 28.19984 12.26759  -10.06271 1.000 17.71069  ? 10  ALA A C    1 
ATOM   212  O O    . ALA A 1 15  ? 27.47600 11.58747  -9.32810  1.000 12.44601  ? 10  ALA A O    1 
ATOM   213  C CB   . ALA A 1 15  ? 29.98875 13.72052  -8.98036  1.000 10.39920  ? 10  ALA A CB   1 
ATOM   214  H H    . ALA A 1 15  ? 30.87279 13.15768  -11.18377 1.000 15.28847  ? 10  ALA A H    1 
ATOM   215  H HA   . ALA A 1 15  ? 29.95298 11.68469  -9.20039  1.000 18.93443  ? 10  ALA A HA   1 
ATOM   216  H HB1  . ALA A 1 15  ? 29.86450 14.48237  -9.56776  1.000 12.50144  ? 10  ALA A HB1  1 
ATOM   217  H HB2  . ALA A 1 15  ? 29.37970 13.78029  -8.22777  1.000 12.50144  ? 10  ALA A HB2  1 
ATOM   218  H HB3  . ALA A 1 15  ? 30.90499 13.69344  -8.66305  1.000 12.50144  ? 10  ALA A HB3  1 
ATOM   219  N N    . LYS A 1 16  ? 27.72662 12.86399  -11.15376 1.000 10.82537  ? 11  LYS A N    1 
ATOM   220  C CA   . LYS A 1 16  ? 26.31331 12.76879  -11.48185 1.000 16.40273  ? 11  LYS A CA   1 
ATOM   221  C C    . LYS A 1 16  ? 25.94011 11.38193  -12.00073 1.000 13.05580  ? 11  LYS A C    1 
ATOM   222  O O    . LYS A 1 16  ? 24.84423 10.88218  -11.70771 1.000 23.18006  ? 11  LYS A O    1 
ATOM   223  C CB   . LYS A 1 16  ? 25.97155 13.87939  -12.48448 1.000 23.71940  ? 11  LYS A CB   1 
ATOM   224  C CG   . LYS A 1 16  ? 26.25144 15.32904  -11.94425 1.000 9.65850   ? 11  LYS A CG   1 
ATOM   225  C CD   . LYS A 1 16  ? 25.69797 16.41158  -12.85946 1.000 29.32863  ? 11  LYS A CD   1 
ATOM   226  C CE   . LYS A 1 16  ? 26.73680 17.51231  -13.13726 1.000 41.37167  ? 11  LYS A CE   1 
ATOM   227  N NZ   . LYS A 1 16  ? 26.13099 18.80143  -13.63959 1.000 54.38790  ? 11  LYS A NZ   1 
ATOM   228  H H    . LYS A 1 16  ? 28.19640 13.32166  -11.71005 1.000 13.01285  ? 11  LYS A H    1 
ATOM   229  H HA   . LYS A 1 16  ? 25.77208 12.90781  -10.68898 1.000 19.70567  ? 11  LYS A HA   1 
ATOM   230  H HB2  . LYS A 1 16  ? 26.50618 13.75299  -13.28391 1.000 28.48568  ? 11  LYS A HB2  1 
ATOM   231  H HB3  . LYS A 1 16  ? 25.02837 13.82208  -12.70364 1.000 28.48568  ? 11  LYS A HB3  1 
ATOM   232  H HG2  . LYS A 1 16  ? 25.83419 15.42926  -11.07433 1.000 11.61260  ? 11  LYS A HG2  1 
ATOM   233  H HG3  . LYS A 1 16  ? 27.20965 15.46008  -11.86967 1.000 11.61260  ? 11  LYS A HG3  1 
ATOM   234  H HD2  . LYS A 1 16  ? 25.44259 16.01452  -13.70682 1.000 35.21676  ? 11  LYS A HD2  1 
ATOM   235  H HD3  . LYS A 1 16  ? 24.92598 16.82197  -12.43932 1.000 35.21676  ? 11  LYS A HD3  1 
ATOM   236  H HE2  . LYS A 1 16  ? 27.21220 17.70903  -12.31495 1.000 49.66840  ? 11  LYS A HE2  1 
ATOM   237  H HE3  . LYS A 1 16  ? 27.35753 17.19422  -13.81136 1.000 49.66840  ? 11  LYS A HE3  1 
ATOM   238  H HZ1  . LYS A 1 16  ? 25.66974 18.65059  -14.38565 1.000 65.28789  ? 11  LYS A HZ1  1 
ATOM   239  H HZ2  . LYS A 1 16  ? 25.58355 19.14026  -13.02509 1.000 65.28789  ? 11  LYS A HZ2  1 
ATOM   240  H HZ3  . LYS A 1 16  ? 26.77337 19.39287  -13.81176 1.000 65.28789  ? 11  LYS A HZ3  1 
ATOM   241  N N    . LEU A 1 17  ? 26.83810 10.71957  -12.72442 1.000 15.57956  ? 12  LEU A N    1 
ATOM   242  C CA   . LEU A 1 17  ? 26.60698 9.32353   -13.11405 1.000 17.28356  ? 12  LEU A CA   1 
ATOM   243  C C    . LEU A 1 17  ? 26.58072 8.37001   -11.89423 1.000 13.63091  ? 12  LEU A C    1 
ATOM   244  O O    . LEU A 1 17  ? 25.75170 7.45524   -11.85116 1.000 25.91338  ? 12  LEU A O    1 
ATOM   245  C CB   . LEU A 1 17  ? 27.67002 8.87710   -14.14277 1.000 16.01791  ? 12  LEU A CB   1 
ATOM   246  C CG   . LEU A 1 17  ? 27.79354 9.57420   -15.51902 1.000 23.58043  ? 12  LEU A CG   1 
ATOM   247  C CD1  . LEU A 1 17  ? 29.20213 9.48479   -16.08003 1.000 9.12489   ? 12  LEU A CD1  1 
ATOM   248  C CD2  . LEU A 1 17  ? 26.81228 9.00453   -16.52988 1.000 19.43126  ? 12  LEU A CD2  1 
ATOM   249  H H    . LEU A 1 17  ? 27.58305 11.04737  -13.00227 1.000 18.71788  ? 12  LEU A H    1 
ATOM   250  H HA   . LEU A 1 17  ? 25.73592 9.26723   -13.53711 1.000 20.76268  ? 12  LEU A HA   1 
ATOM   251  H HB2  . LEU A 1 17  ? 28.53530 8.97813   -13.71616 1.000 19.24389  ? 12  LEU A HB2  1 
ATOM   252  H HB3  . LEU A 1 17  ? 27.50176 7.94117   -14.33417 1.000 19.24389  ? 12  LEU A HB3  1 
ATOM   253  H HG   . LEU A 1 17  ? 27.58185 10.50989  -15.37554 1.000 28.31892  ? 12  LEU A HG   1 
ATOM   254  H HD11 . LEU A 1 17  ? 29.81802 9.89721   -15.45433 1.000 10.97226  ? 12  LEU A HD11 1 
ATOM   255  H HD12 . LEU A 1 17  ? 29.43353 8.55115   -16.20521 1.000 10.97226  ? 12  LEU A HD12 1 
ATOM   256  H HD13 . LEU A 1 17  ? 29.23347 9.95025   -16.93048 1.000 10.97226  ? 12  LEU A HD13 1 
ATOM   257  H HD21 . LEU A 1 17  ? 26.96157 8.04955   -16.61135 1.000 23.33992  ? 12  LEU A HD21 1 
ATOM   258  H HD22 . LEU A 1 17  ? 25.90806 9.17287   -16.22175 1.000 23.33992  ? 12  LEU A HD22 1 
ATOM   259  H HD23 . LEU A 1 17  ? 26.95545 9.43600   -17.38675 1.000 23.33992  ? 12  LEU A HD23 1 
ATOM   260  N N    . ALA A 1 18  ? 27.47912 8.54703   -10.91740 1.000 10.56957  ? 13  ALA A N    1 
ATOM   261  C CA   . ALA A 1 18  ? 27.46145 7.75301   -9.67062  1.000 12.52080  ? 13  ALA A CA   1 
ATOM   262  C C    . ALA A 1 18  ? 26.16882 7.91966   -8.88833  1.000 16.88357  ? 13  ALA A C    1 
ATOM   263  O O    . ALA A 1 18  ? 25.62519 6.94449   -8.35481  1.000 22.80846  ? 13  ALA A O    1 
ATOM   264  C CB   . ALA A 1 18  ? 28.62644 8.13950   -8.74725  1.000 9.66646   ? 13  ALA A CB   1 
ATOM   265  H H    . ALA A 1 18  ? 28.11664 9.12351   -10.94624 1.000 12.70588  ? 13  ALA A H    1 
ATOM   266  H HA   . ALA A 1 18  ? 27.55507 6.82623   -9.94122  1.000 15.04736  ? 13  ALA A HA   1 
ATOM   267  H HB1  . ALA A 1 18  ? 28.41953 8.98213   -8.31359  1.000 11.62216  ? 13  ALA A HB1  1 
ATOM   268  H HB2  . ALA A 1 18  ? 28.74499 7.44481   -8.08074  1.000 11.62216  ? 13  ALA A HB2  1 
ATOM   269  H HB3  . ALA A 1 18  ? 29.43337 8.22997   -9.27789  1.000 11.62216  ? 13  ALA A HB3  1 
ATOM   270  N N    . GLU A 1 19  ? 25.68451 9.15032   -8.76351  1.000 17.51747  ? 14  GLU A N    1 
ATOM   271  C CA   . GLU A 1 19  ? 24.37122 9.35638   -8.15343  1.000 35.21747  ? 14  GLU A CA   1 
ATOM   272  C C    . GLU A 1 19  ? 23.29963 8.51529   -8.83379  1.000 22.71539  ? 14  GLU A C    1 
ATOM   273  O O    . GLU A 1 19  ? 22.47877 7.87869   -8.17053  1.000 30.52512  ? 14  GLU A O    1 
ATOM   274  C CB   . GLU A 1 19  ? 23.99728 10.83682  -8.23182  1.000 30.17521  ? 14  GLU A CB   1 
ATOM   275  C CG   . GLU A 1 19  ? 22.81998 11.28648  -7.38790  1.000 30.68433  ? 14  GLU A CG   1 
ATOM   276  C CD   . GLU A 1 19  ? 22.56328 12.77211  -7.59796  1.000 41.82946  ? 14  GLU A CD   1 
ATOM   277  O OE1  . GLU A 1 19  ? 22.68247 13.26798  -8.75490  1.000 52.34417  ? 14  GLU A OE1  1 
ATOM   278  O OE2  . GLU A 1 19  ? 22.27035 13.45301  -6.61131  1.000 17.54753  ? 14  GLU A OE2  1 
ATOM   279  H H    . GLU A 1 19  ? 26.08450 9.86818   -9.01704  1.000 21.04336  ? 14  GLU A H    1 
ATOM   280  H HA   . GLU A 1 19  ? 24.41869 9.09025   -7.22186  1.000 42.28337  ? 14  GLU A HA   1 
ATOM   281  H HB2  . GLU A 1 19  ? 24.76536 11.35630  -7.94706  1.000 36.23265  ? 14  GLU A HB2  1 
ATOM   282  H HB3  . GLU A 1 19  ? 23.78048 11.04360  -9.15439  1.000 36.23265  ? 14  GLU A HB3  1 
ATOM   283  H HG2  . GLU A 1 19  ? 22.02565 10.79377  -7.64708  1.000 36.84360  ? 14  GLU A HG2  1 
ATOM   284  H HG3  . GLU A 1 19  ? 23.01375 11.13378  -6.44980  1.000 36.84360  ? 14  GLU A HG3  1 
ATOM   285  N N    . GLN A 1 20  ? 23.24650 8.56722   -10.16985 1.000 24.07800  ? 15  GLN A N    1 
ATOM   286  C CA   . GLN A 1 20  ? 22.25144 7.80182   -10.91506 1.000 16.04581  ? 15  GLN A CA   1 
ATOM   287  C C    . GLN A 1 20  ? 22.36501 6.30924   -10.64230 1.000 18.82926  ? 15  GLN A C    1 
ATOM   288  O O    . GLN A 1 20  ? 21.35430 5.61091   -10.50166 1.000 30.87687  ? 15  GLN A O    1 
ATOM   289  C CB   . GLN A 1 20  ? 22.43426 8.05584   -12.40733 1.000 21.05244  ? 15  GLN A CB   1 
ATOM   290  C CG   . GLN A 1 20  ? 21.83803 9.36206   -12.91502 1.000 23.62349  ? 15  GLN A CG   1 
ATOM   291  C CD   . GLN A 1 20  ? 21.87918 9.44757   -14.42975 1.000 53.77325  ? 15  GLN A CD   1 
ATOM   292  O OE1  . GLN A 1 20  ? 21.04150 8.85456   -15.12313 1.000 34.71759  ? 15  GLN A OE1  1 
ATOM   293  N NE2  . GLN A 1 20  ? 22.87049 10.17852  -14.95888 1.000 50.13979  ? 15  GLN A NE2  1 
ATOM   294  H H    . GLN A 1 20  ? 23.77295 9.03568   -10.66279 1.000 28.91601  ? 15  GLN A H    1 
ATOM   295  H HA   . GLN A 1 20  ? 21.36889 8.09492   -10.63920 1.000 19.27737  ? 15  GLN A HA   1 
ATOM   296  H HB2  . GLN A 1 20  ? 23.38445 8.07491   -12.60142 1.000 25.28533  ? 15  GLN A HB2  1 
ATOM   297  H HB3  . GLN A 1 20  ? 22.01026 7.33314   -12.89604 1.000 25.28533  ? 15  GLN A HB3  1 
ATOM   298  H HG2  . GLN A 1 20  ? 20.91224 9.42261   -12.63193 1.000 28.37059  ? 15  GLN A HG2  1 
ATOM   299  H HG3  . GLN A 1 20  ? 22.34459 10.10654  -12.55440 1.000 28.37059  ? 15  GLN A HG3  1 
ATOM   300  H HE21 . GLN A 1 20  ? 23.43940 10.56779  -14.44467 1.000 60.19015  ? 15  GLN A HE21 1 
ATOM   301  H HE22 . GLN A 1 20  ? 22.93755 10.25819  -15.81255 1.000 60.19015  ? 15  GLN A HE22 1 
ATOM   302  N N    . ALA A 1 21  ? 23.58290 5.78969   -10.61772 1.000 17.33151  ? 16  ALA A N    1 
ATOM   303  C CA   . ALA A 1 21  ? 23.79716 4.39511   -10.30936 1.000 17.68208  ? 16  ALA A CA   1 
ATOM   304  C C    . ALA A 1 21  ? 23.58350 4.04965   -8.83993  1.000 23.98115  ? 16  ALA A C    1 
ATOM   305  O O    . ALA A 1 21  ? 23.68652 2.86675   -8.49228  1.000 35.78066  ? 16  ALA A O    1 
ATOM   306  C CB   . ALA A 1 21  ? 25.22489 4.02379   -10.69168 1.000 23.35797  ? 16  ALA A CB   1 
ATOM   307  H H    . ALA A 1 21  ? 24.30399 6.23019   -10.77769 1.000 20.82021  ? 16  ALA A H    1 
ATOM   308  H HA   . ALA A 1 21  ? 23.16686 3.86856   -10.82547 1.000 21.24090  ? 16  ALA A HA   1 
ATOM   309  H HB1  . ALA A 1 21  ? 25.36438 3.08056   -10.51347 1.000 28.05197  ? 16  ALA A HB1  1 
ATOM   310  H HB2  . ALA A 1 21  ? 25.35639 4.20509   -11.63547 1.000 28.05197  ? 16  ALA A HB2  1 
ATOM   311  H HB3  . ALA A 1 21  ? 25.84146 4.55488   -10.16378 1.000 28.05197  ? 16  ALA A HB3  1 
ATOM   312  N N    . GLU A 1 22  ? 23.38554 5.04009   -7.96676  1.000 17.47229  ? 17  GLU A N    1 
ATOM   313  C CA   . GLU A 1 22  ? 23.39378 4.86704   -6.49828  1.000 23.92659  ? 17  GLU A CA   1 
ATOM   314  C C    . GLU A 1 22  ? 24.73323 4.35614   -5.94461  1.000 18.74465  ? 17  GLU A C    1 
ATOM   315  O O    . GLU A 1 22  ? 24.75995 3.45825   -5.11553  1.000 20.31380  ? 17  GLU A O    1 
ATOM   316  C CB   . GLU A 1 22  ? 22.26971 3.92270   -6.06239  1.000 25.14230  ? 17  GLU A CB   1 
ATOM   317  C CG   . GLU A 1 22  ? 20.88049 4.46085   -6.35457  1.000 36.47338  ? 17  GLU A CG   1 
ATOM   318  C CD   . GLU A 1 22  ? 19.77334 3.46740   -6.07997  1.000 29.87313  ? 17  GLU A CD   1 
ATOM   319  O OE1  . GLU A 1 22  ? 20.01440 2.45639   -5.37813  1.000 55.24733  ? 17  GLU A OE1  1 
ATOM   320  O OE2  . GLU A 1 22  ? 18.65671 3.71047   -6.56184  1.000 26.04576  ? 17  GLU A OE2  1 
ATOM   321  H H    . GLU A 1 22  ? 23.23835 5.85403   -8.20220  1.000 20.98915  ? 17  GLU A H    1 
ATOM   322  H HA   . GLU A 1 22  ? 23.25765 5.74997   -6.12038  1.000 28.73431  ? 17  GLU A HA   1 
ATOM   323  H HB2  . GLU A 1 22  ? 22.36776 3.08082   -6.53412  1.000 30.19315  ? 17  GLU A HB2  1 
ATOM   324  H HB3  . GLU A 1 22  ? 22.33696 3.77677   -5.10579  1.000 30.19315  ? 17  GLU A HB3  1 
ATOM   325  H HG2  . GLU A 1 22  ? 20.72378 5.23983   -5.79821  1.000 43.79046  ? 17  GLU A HG2  1 
ATOM   326  H HG3  . GLU A 1 22  ? 20.83147 4.70705   -7.29152  1.000 43.79046  ? 17  GLU A HG3  1 
ATOM   327  N N    . ARG A 1 23  ? 25.84722 4.96381   -6.38602  1.000 21.74562  ? 18  ARG A N    1 
ATOM   328  C CA   . ARG A 1 23  ? 27.21011 4.55341   -6.01121  1.000 10.96593  ? 18  ARG A CA   1 
ATOM   329  C C    . ARG A 1 23  ? 27.89466 5.71434   -5.28349  1.000 11.77462  ? 18  ARG A C    1 
ATOM   330  O O    . ARG A 1 23  ? 28.76897 6.39565   -5.83294  1.000 14.91162  ? 18  ARG A O    1 
ATOM   331  C CB   . ARG A 1 23  ? 28.02544 4.11369   -7.21293  1.000 7.89097   ? 18  ARG A CB   1 
ATOM   332  C CG   . ARG A 1 23  ? 27.55640 2.79164   -7.87424  1.000 21.55395  ? 18  ARG A CG   1 
ATOM   333  C CD   . ARG A 1 23  ? 28.36530 1.60087   -7.38023  1.000 28.28791  ? 18  ARG A CD   1 
ATOM   334  N NE   . ARG A 1 23  ? 29.78010 1.67355   -7.74777  1.000 18.19705  ? 18  ARG A NE   1 
ATOM   335  C CZ   . ARG A 1 23  ? 30.65617 0.68271   -7.61258  1.000 20.04443  ? 18  ARG A CZ   1 
ATOM   336  N NH1  . ARG A 1 23  ? 30.28384 -0.53639  -7.23588  1.000 31.68893  ? 18  ARG A NH1  1 
ATOM   337  N NH2  . ARG A 1 23  ? 31.94058 0.92354   -7.83199  1.000 18.81210  ? 18  ARG A NH2  1 
ATOM   338  H H    . ARG A 1 23  ? 25.83666 5.63746   -6.92052  1.000 26.11714  ? 18  ARG A H    1 
ATOM   339  H HA   . ARG A 1 23  ? 27.12742 3.80157   -5.40392  1.000 13.18152  ? 18  ARG A HA   1 
ATOM   340  H HB2  . ARG A 1 23  ? 27.97788 4.80920   -7.88739  1.000 9.49157   ? 18  ARG A HB2  1 
ATOM   341  H HB3  . ARG A 1 23  ? 28.94486 3.98758   -6.93068  1.000 9.49157   ? 18  ARG A HB3  1 
ATOM   342  H HG2  . ARG A 1 23  ? 26.62371 2.63735   -7.65706  1.000 25.88714  ? 18  ARG A HG2  1 
ATOM   343  H HG3  . ARG A 1 23  ? 27.66675 2.85689   -8.83573  1.000 25.88714  ? 18  ARG A HG3  1 
ATOM   344  H HD2  . ARG A 1 23  ? 28.31036 1.56279   -6.41254  1.000 33.96789  ? 18  ARG A HD2  1 
ATOM   345  H HD3  . ARG A 1 23  ? 27.99860 0.78970   -7.76552  1.000 33.96789  ? 18  ARG A HD3  1 
ATOM   346  H HE   . ARG A 1 23  ? 30.06696 2.41459   -8.07665  1.000 21.85886  ? 18  ARG A HE   1 
ATOM   347  H HH11 . ARG A 1 23  ? 29.45595 -0.70174  -7.07201  1.000 38.04911  ? 18  ARG A HH11 1 
ATOM   348  H HH12 . ARG A 1 23  ? 30.87084 -1.15982  -7.15601  1.000 38.04911  ? 18  ARG A HH12 1 
ATOM   349  H HH21 . ARG A 1 23  ? 32.19759 1.71235   -8.05853  1.000 22.59693  ? 18  ARG A HH21 1 
ATOM   350  H HH22 . ARG A 1 23  ? 32.51716 0.29103   -7.74786  1.000 22.59693  ? 18  ARG A HH22 1 
ATOM   351  N N    . TYR A 1 24  ? 27.50690 5.91100   -4.02526  1.000 12.15378  ? 19  TYR A N    1 
ATOM   352  C CA   . TYR A 1 24  ? 27.83085 7.12840   -3.29899  1.000 15.55860  ? 19  TYR A CA   1 
ATOM   353  C C    . TYR A 1 24  ? 29.23882 7.16562   -2.72620  1.000 20.87651  ? 19  TYR A C    1 
ATOM   354  O O    . TYR A 1 24  ? 29.73482 8.26058   -2.45890  1.000 21.75959  ? 19  TYR A O    1 
ATOM   355  C CB   . TYR A 1 24  ? 26.83758 7.31880   -2.17171  1.000 14.06572  ? 19  TYR A CB   1 
ATOM   356  C CG   . TYR A 1 24  ? 25.40761 7.40961   -2.65237  1.000 19.93448  ? 19  TYR A CG   1 
ATOM   357  C CD1  . TYR A 1 24  ? 24.92004 8.57190   -3.27520  1.000 21.55347  ? 19  TYR A CD1  1 
ATOM   358  C CD2  . TYR A 1 24  ? 24.52458 6.34711   -2.46856  1.000 19.01874  ? 19  TYR A CD2  1 
ATOM   359  C CE1  . TYR A 1 24  ? 23.59392 8.64916   -3.70378  1.000 33.06584  ? 19  TYR A CE1  1 
ATOM   360  C CE2  . TYR A 1 24  ? 23.19208 6.43114   -2.88618  1.000 21.63332  ? 19  TYR A CE2  1 
ATOM   361  C CZ   . TYR A 1 24  ? 22.74151 7.57067   -3.50666  1.000 22.39245  ? 19  TYR A CZ   1 
ATOM   362  O OH   . TYR A 1 24  ? 21.42801 7.61522   -3.90581  1.000 30.23521  ? 19  TYR A OH   1 
ATOM   363  H H    . TYR A 1 24  ? 27.04934 5.34570   -3.56627  1.000 14.60693  ? 19  TYR A H    1 
ATOM   364  H HA   . TYR A 1 24  ? 27.76330 7.86885   -3.92196  1.000 18.69272  ? 19  TYR A HA   1 
ATOM   365  H HB2  . TYR A 1 24  ? 26.90191 6.56471   -1.56499  1.000 16.90127  ? 19  TYR A HB2  1 
ATOM   366  H HB3  . TYR A 1 24  ? 27.04819 8.14115   -1.70235  1.000 16.90127  ? 19  TYR A HB3  1 
ATOM   367  H HD1  . TYR A 1 24  ? 25.48753 9.29751   -3.40310  1.000 25.88657  ? 19  TYR A HD1  1 
ATOM   368  H HD2  . TYR A 1 24  ? 24.82677 5.56784   -2.06073  1.000 22.84489  ? 19  TYR A HD2  1 
ATOM   369  H HE1  . TYR A 1 24  ? 23.28224 9.42024   -4.11992  1.000 39.70141  ? 19  TYR A HE1  1 
ATOM   370  H HE2  . TYR A 1 24  ? 22.61297 5.71746   -2.74408  1.000 25.98239  ? 19  TYR A HE2  1 
ATOM   371  H HH   . TYR A 1 24  ? 21.04507 6.89236   -3.71497  1.000 36.30466  ? 19  TYR A HH   1 
ATOM   372  N N    . GLU A 1 25  ? 29.90630 6.02665   -2.52957  1.000 21.50626  ? 20  GLU A N    1 
ATOM   373  C CA   . GLU A 1 25  ? 31.32959 6.07698   -2.19389  1.000 16.72731  ? 20  GLU A CA   1 
ATOM   374  C C    . GLU A 1 25  ? 32.14461 6.66830   -3.34696  1.000 22.26297  ? 20  GLU A C    1 
ATOM   375  O O    . GLU A 1 25  ? 33.02213 7.51551   -3.13879  1.000 22.57032  ? 20  GLU A O    1 
ATOM   376  C CB   . GLU A 1 25  ? 31.86184 4.68383   -1.83705  1.000 28.87885  ? 20  GLU A CB   1 
ATOM   377  C CG   . GLU A 1 25  ? 31.55087 4.18161   -0.46374  1.000 35.74725  ? 20  GLU A CG   1 
ATOM   378  C CD   . GLU A 1 25  ? 32.62520 3.21832   0.06234   1.000 59.57608  ? 20  GLU A CD   1 
ATOM   379  O OE1  . GLU A 1 25  ? 33.63190 2.99656   -0.64377  1.000 54.84873  ? 20  GLU A OE1  1 
ATOM   380  O OE2  . GLU A 1 25  ? 32.48367 2.69536   1.19169   1.000 48.41778  ? 20  GLU A OE2  1 
ATOM   381  H H    . GLU A 1 25  ? 29.56954 5.23712   -2.58277  1.000 25.82991  ? 20  GLU A H    1 
ATOM   382  H HA   . GLU A 1 25  ? 31.43134 6.64259   -1.41246  1.000 20.09517  ? 20  GLU A HA   1 
ATOM   383  H HB2  . GLU A 1 25  ? 31.48441 4.04766   -2.46453  1.000 34.67703  ? 20  GLU A HB2  1 
ATOM   384  H HB3  . GLU A 1 25  ? 32.82800 4.70000   -1.92173  1.000 34.67703  ? 20  GLU A HB3  1 
ATOM   385  H HG2  . GLU A 1 25  ? 31.49647 4.93466   0.14524   1.000 42.91910  ? 20  GLU A HG2  1 
ATOM   386  H HG3  . GLU A 1 25  ? 30.70436 3.70836   -0.48258  1.000 42.91910  ? 20  GLU A HG3  1 
ATOM   387  N N    . ASP A 1 26  ? 31.89334 6.19293   -4.57100  1.000 15.75910  ? 21  ASP A N    1 
ATOM   388  C CA   . ASP A 1 26  ? 32.46144 6.80890   -5.76783  1.000 32.41181  ? 21  ASP A CA   1 
ATOM   389  C C    . ASP A 1 26  ? 32.08699 8.28757   -5.86526  1.000 19.30604  ? 21  ASP A C    1 
ATOM   390  O O    . ASP A 1 26  ? 32.92326 9.13824   -6.20974  1.000 18.26749  ? 21  ASP A O    1 
ATOM   391  C CB   . ASP A 1 26  ? 31.95595 6.10058   -7.03843  1.000 22.13725  ? 21  ASP A CB   1 
ATOM   392  C CG   . ASP A 1 26  ? 32.52897 4.69992   -7.23489  1.000 25.78531  ? 21  ASP A CG   1 
ATOM   393  O OD1  . ASP A 1 26  ? 33.31730 4.24926   -6.36991  1.000 18.63458  ? 21  ASP A OD1  1 
ATOM   394  O OD2  . ASP A 1 26  ? 32.15215 4.03676   -8.26433  1.000 21.31920  ? 21  ASP A OD2  1 
ATOM   395  H H    . ASP A 1 26  ? 31.39468 5.51169   -4.73488  1.000 18.93332  ? 21  ASP A H    1 
ATOM   396  H HA   . ASP A 1 26  ? 33.42546 6.71718   -5.71166  1.000 38.91658  ? 21  ASP A HA   1 
ATOM   397  H HB2  . ASP A 1 26  ? 30.99066 6.01998   -6.98726  1.000 26.58710  ? 21  ASP A HB2  1 
ATOM   398  H HB3  . ASP A 1 26  ? 32.20400 6.63193   -7.81112  1.000 26.58710  ? 21  ASP A HB3  1 
ATOM   399  N N    . MET A 1 27  ? 30.81874 8.60338   -5.61523  1.000 16.67740  ? 22  MET A N    1 
ATOM   400  C CA   . MET A 1 27  ? 30.36837 9.98952   -5.72082  1.000 11.81180  ? 22  MET A CA   1 
ATOM   401  C C    . MET A 1 27  ? 31.16514 10.87773  -4.76088  1.000 18.17753  ? 22  MET A C    1 
ATOM   402  O O    . MET A 1 27  ? 31.66146 11.93415  -5.15078  1.000 10.74288  ? 22  MET A O    1 
ATOM   403  C CB   . MET A 1 27  ? 28.85814 10.03078  -5.48155  1.000 5.56890   ? 22  MET A CB   1 
ATOM   404  C CG   . MET A 1 27  ? 28.13150 11.31277  -5.94370  1.000 9.00488   ? 22  MET A CG   1 
ATOM   405  S SD   . MET A 1 27  ? 26.57160 11.44986  -5.05856  1.000 19.22238  ? 22  MET A SD   1 
ATOM   406  C CE   . MET A 1 27  ? 25.79065 12.79842  -5.86867  1.000 9.09296   ? 22  MET A CE   1 
ATOM   407  H H    . MET A 1 27  ? 30.20725 8.04378   -5.38607  1.000 20.03528  ? 22  MET A H    1 
ATOM   408  H HA   . MET A 1 27  ? 30.51234 10.34068  -6.61349  1.000 14.19656  ? 22  MET A HA   1 
ATOM   409  H HB2  . MET A 1 27  ? 28.45601 9.28694   -5.95684  1.000 6.70508   ? 22  MET A HB2  1 
ATOM   410  H HB3  . MET A 1 27  ? 28.70009 9.94009   -4.52882  1.000 6.70508   ? 22  MET A HB3  1 
ATOM   411  H HG2  . MET A 1 27  ? 28.67614 12.09089  -5.74675  1.000 10.82826  ? 22  MET A HG2  1 
ATOM   412  H HG3  . MET A 1 27  ? 27.95166 11.26605  -6.89574  1.000 10.82826  ? 22  MET A HG3  1 
ATOM   413  H HE1  . MET A 1 27  ? 24.91970 12.94606  -5.46798  1.000 10.93395  ? 22  MET A HE1  1 
ATOM   414  H HE2  . MET A 1 27  ? 26.34091 13.59052  -5.76522  1.000 10.93395  ? 22  MET A HE2  1 
ATOM   415  H HE3  . MET A 1 27  ? 25.69008 12.58613  -6.80979  1.000 10.93395  ? 22  MET A HE3  1 
ATOM   416  N N    . ALA A 1 28  ? 31.39430 10.41858  -3.53378  1.000 13.02665  ? 23  ALA A N    1 
ATOM   417  C CA   . ALA A 1 28  ? 32.08783 11.25978  -2.57088  1.000 11.82619  ? 23  ALA A CA   1 
ATOM   418  C C    . ALA A 1 28  ? 33.54778 11.47655  -2.95648  1.000 17.10380  ? 23  ALA A C    1 
ATOM   419  O O    . ALA A 1 28  ? 34.09930 12.55302  -2.69974  1.000 14.81596  ? 23  ALA A O    1 
ATOM   420  C CB   . ALA A 1 28  ? 31.96574 10.64112  -1.15263  1.000 11.95419  ? 23  ALA A CB   1 
ATOM   421  H H    . ALA A 1 28  ? 31.16375 9.64301   -3.24232  1.000 15.65438  ? 23  ALA A H    1 
ATOM   422  H HA   . ALA A 1 28  ? 31.66686 12.13336  -2.54792  1.000 14.21383  ? 23  ALA A HA   1 
ATOM   423  H HB1  . ALA A 1 28  ? 31.02701 10.56968  -0.91900  1.000 14.36743  ? 23  ALA A HB1  1 
ATOM   424  H HB2  . ALA A 1 28  ? 32.37373 9.76110   -1.15576  1.000 14.36743  ? 23  ALA A HB2  1 
ATOM   425  H HB3  . ALA A 1 28  ? 32.42195 11.21496  -0.51743  1.000 14.36743  ? 23  ALA A HB3  1 
ATOM   426  N N    . ALA A 1 29  ? 34.20062 10.48581  -3.57082  1.000 10.69869  ? 24  ALA A N    1 
ATOM   427  C CA   . ALA A 1 29  ? 35.61804 10.65503  -3.85789  1.000 17.45727  ? 24  ALA A CA   1 
ATOM   428  C C    . ALA A 1 29  ? 35.86480 11.52234  -5.09252  1.000 14.46160  ? 24  ALA A C    1 
ATOM   429  O O    . ALA A 1 29  ? 36.91588 12.18003  -5.17531  1.000 12.73996  ? 24  ALA A O    1 
ATOM   430  C CB   . ALA A 1 29  ? 36.26247 9.28631   -4.01731  1.000 7.90228   ? 24  ALA A CB   1 
ATOM   431  H H    . ALA A 1 29  ? 33.85628 9.73813   -3.81984  1.000 12.86083  ? 24  ALA A H    1 
ATOM   432  H HA   . ALA A 1 29  ? 36.04541 11.10464  -3.11217  1.000 20.97112  ? 24  ALA A HA   1 
ATOM   433  H HB1  . ALA A 1 29  ? 36.13419 8.77974   -3.20010  1.000 9.50513   ? 24  ALA A HB1  1 
ATOM   434  H HB2  . ALA A 1 29  ? 35.84454 8.82520   -4.76136  1.000 9.50513   ? 24  ALA A HB2  1 
ATOM   435  H HB3  . ALA A 1 29  ? 37.21004 9.40154   -4.18975  1.000 9.50513   ? 24  ALA A HB3  1 
ATOM   436  N N    . PHE A 1 30  ? 34.95586 11.46566  -6.07945  1.000 13.74824  ? 25  PHE A N    1 
ATOM   437  C CA   . PHE A 1 30  ? 34.95060 12.41690  -7.20176  1.000 23.32688  ? 25  PHE A CA   1 
ATOM   438  C C    . PHE A 1 30  ? 34.80861 13.87350  -6.73033  1.000 22.30343  ? 25  PHE A C    1 
ATOM   439  O O    . PHE A 1 30  ? 35.44687 14.77893  -7.28145  1.000 11.85997  ? 25  PHE A O    1 
ATOM   440  C CB   . PHE A 1 30  ? 33.79550 12.09769  -8.16848  1.000 8.45775   ? 25  PHE A CB   1 
ATOM   441  C CG   . PHE A 1 30  ? 33.98525 10.80914  -8.95036  1.000 15.04585  ? 25  PHE A CG   1 
ATOM   442  C CD1  . PHE A 1 30  ? 35.23491 10.46852  -9.45585  1.000 11.86263  ? 25  PHE A CD1  1 
ATOM   443  C CD2  . PHE A 1 30  ? 32.92138 9.95159   -9.18337  1.000 18.28463  ? 25  PHE A CD2  1 
ATOM   444  C CE1  . PHE A 1 30  ? 35.44189 9.29644   -10.16599 1.000 11.34371  ? 25  PHE A CE1  1 
ATOM   445  C CE2  . PHE A 1 30  ? 33.10770 8.75212   -9.91314  1.000 14.09280  ? 25  PHE A CE2  1 
ATOM   446  C CZ   . PHE A 1 30  ? 34.37384 8.43855   -10.40124 1.000 21.96579  ? 25  PHE A CZ   1 
ATOM   447  H H    . PHE A 1 30  ? 34.32631 10.88142  -6.12349  1.000 16.52029  ? 25  PHE A H    1 
ATOM   448  H HA   . PHE A 1 30  ? 35.79767 12.32015  -7.66438  1.000 28.01466  ? 25  PHE A HA   1 
ATOM   449  H HB2  . PHE A 1 30  ? 32.97544 12.01486  -7.65706  1.000 10.17170  ? 25  PHE A HB2  1 
ATOM   450  H HB3  . PHE A 1 30  ? 33.71572 12.82241  -8.80826  1.000 10.17170  ? 25  PHE A HB3  1 
ATOM   451  H HD1  . PHE A 1 30  ? 35.95203 11.04330  -9.31345  1.000 14.25756  ? 25  PHE A HD1  1 
ATOM   452  H HD2  . PHE A 1 30  ? 32.07717 10.16591  -8.85737  1.000 21.96396  ? 25  PHE A HD2  1 
ATOM   453  H HE1  . PHE A 1 30  ? 36.29023 9.08524   -10.48318 1.000 13.63485  ? 25  PHE A HE1  1 
ATOM   454  H HE2  . PHE A 1 30  ? 32.39110 8.17913   -10.06501 1.000 16.93376  ? 25  PHE A HE2  1 
ATOM   455  H HZ   . PHE A 1 30  ? 34.50475 7.65495   -10.88471 1.000 26.38135  ? 25  PHE A HZ   1 
ATOM   456  N N    . MET A 1 31  ? 33.93256 14.12644  -5.75117  1.000 13.81605  ? 26  MET A N    1 
ATOM   457  C CA   . MET A 1 31  ? 33.69197 15.49483  -5.30294  1.000 7.38800   ? 26  MET A CA   1 
ATOM   458  C C    . MET A 1 31  ? 34.78870 15.97449  -4.35389  1.000 18.17820  ? 26  MET A C    1 
ATOM   459  O O    . MET A 1 31  ? 35.07897 17.17893  -4.30318  1.000 20.25661  ? 26  MET A O    1 
ATOM   460  C CB   . MET A 1 31  ? 32.33294 15.57688  -4.61546  1.000 6.14336   ? 26  MET A CB   1 
ATOM   461  C CG   . MET A 1 31  ? 31.15987 15.36964  -5.48453  1.000 5.71164   ? 26  MET A CG   1 
ATOM   462  S SD   . MET A 1 31  ? 31.10061 16.54572  -6.88512  1.000 15.94669  ? 26  MET A SD   1 
ATOM   463  C CE   . MET A 1 31  ? 31.11798 18.10621  -6.14158  1.000 17.28291  ? 26  MET A CE   1 
ATOM   464  H H    . MET A 1 31  ? 33.47234 13.52916  -5.33759  1.000 16.60166  ? 26  MET A H    1 
ATOM   465  H HA   . MET A 1 31  ? 33.67000 16.08182  -6.07486  1.000 8.88800   ? 26  MET A HA   1 
ATOM   466  H HB2  . MET A 1 31  ? 32.30119 14.89803  -3.92332  1.000 7.39444   ? 26  MET A HB2  1 
ATOM   467  H HB3  . MET A 1 31  ? 32.24533 16.45825  -4.21997  1.000 7.39444   ? 26  MET A HB3  1 
ATOM   468  H HG2  . MET A 1 31  ? 31.19083 14.47102  -5.84842  1.000 6.87637   ? 26  MET A HG2  1 
ATOM   469  H HG3  . MET A 1 31  ? 30.35275 15.48736  -4.95954  1.000 6.87637   ? 26  MET A HG3  1 
ATOM   470  H HE1  . MET A 1 31  ? 31.06378 18.78554  -6.83184  1.000 20.76189  ? 26  MET A HE1  1 
ATOM   471  H HE2  . MET A 1 31  ? 30.35717 18.17997  -5.54441  1.000 20.76189  ? 26  MET A HE2  1 
ATOM   472  H HE3  . MET A 1 31  ? 31.94253 18.20834  -5.64099  1.000 20.76189  ? 26  MET A HE3  1 
ATOM   473  N N    . LYS A 1 32  ? 35.36445 15.06907  -3.56307  1.000 16.09353  ? 27  LYS A N    1 
ATOM   474  C CA   . LYS A 1 32  ? 36.57897 15.40359  -2.83903  1.000 7.20115   ? 27  LYS A CA   1 
ATOM   475  C C    . LYS A 1 32  ? 37.64777 15.90180  -3.81515  1.000 13.61820  ? 27  LYS A C    1 
ATOM   476  O O    . LYS A 1 32  ? 38.29609 16.93036  -3.58226  1.000 16.65734  ? 27  LYS A O    1 
ATOM   477  C CB   . LYS A 1 32  ? 37.05812 14.18110  -2.03606  1.000 16.69629  ? 27  LYS A CB   1 
ATOM   478  C CG   . LYS A 1 32  ? 38.33956 14.44233  -1.16776  1.000 9.85006   ? 27  LYS A CG   1 
ATOM   479  C CD   . LYS A 1 32  ? 38.68675 13.27736  -0.29700  1.000 20.61036  ? 27  LYS A CD   1 
ATOM   480  C CE   . LYS A 1 32  ? 39.95460 13.52379  0.55399   1.000 18.93422  ? 27  LYS A CE   1 
ATOM   481  N NZ   . LYS A 1 32  ? 41.26175 13.35264  -0.16663  1.000 36.75123  ? 27  LYS A NZ   1 
ATOM   482  H H    . LYS A 1 32  ? 35.07437 14.26992  -3.43343  1.000 19.33463  ? 27  LYS A H    1 
ATOM   483  H HA   . LYS A 1 32  ? 36.40478 16.11235  -2.20011  1.000 8.66378   ? 27  LYS A HA   1 
ATOM   484  H HB2  . LYS A 1 32  ? 36.34723 13.90644  -1.43597  1.000 20.05795  ? 27  LYS A HB2  1 
ATOM   485  H HB3  . LYS A 1 32  ? 37.26421 13.46432  -2.65625  1.000 20.05795  ? 27  LYS A HB3  1 
ATOM   486  H HG2  . LYS A 1 32  ? 39.09204 14.61339  -1.75547  1.000 11.84247  ? 27  LYS A HG2  1 
ATOM   487  H HG3  . LYS A 1 32  ? 38.18440 15.20996  -0.59543  1.000 11.84247  ? 27  LYS A HG3  1 
ATOM   488  H HD2  . LYS A 1 32  ? 37.94888 13.10347  0.30816   1.000 24.75484  ? 27  LYS A HD2  1 
ATOM   489  H HD3  . LYS A 1 32  ? 38.84736 12.50108  -0.85600  1.000 24.75484  ? 27  LYS A HD3  1 
ATOM   490  H HE2  . LYS A 1 32  ? 39.92674 14.43434  0.88719   1.000 22.74346  ? 27  LYS A HE2  1 
ATOM   491  H HE3  . LYS A 1 32  ? 39.95095 12.89880  1.29579   1.000 22.74346  ? 27  LYS A HE3  1 
ATOM   492  H HZ1  . LYS A 1 32  ? 41.30418 12.54212  -0.53180  1.000 44.12387  ? 27  LYS A HZ1  1 
ATOM   493  H HZ2  . LYS A 1 32  ? 41.33713 13.96341  -0.80958  1.000 44.12387  ? 27  LYS A HZ2  1 
ATOM   494  H HZ3  . LYS A 1 32  ? 41.93844 13.44837  0.40347   1.000 44.12387  ? 27  LYS A HZ3  1 
ATOM   495  N N    . GLY A 1 33  ? 37.82798 15.19461  -4.93747  1.000 26.76382  ? 28  GLY A N    1 
ATOM   496  C CA   . GLY A 1 33  ? 38.88955 15.54765  -5.87395  1.000 17.68867  ? 28  GLY A CA   1 
ATOM   497  C C    . GLY A 1 33  ? 38.63102 16.84865  -6.62115  1.000 18.31090  ? 28  GLY A C    1 
ATOM   498  O O    . GLY A 1 33  ? 39.57118 17.55581  -7.00118  1.000 15.52664  ? 28  GLY A O    1 
ATOM   499  H H    . GLY A 1 33  ? 37.35441 14.51660  -5.17337  1.000 32.13898  ? 28  GLY A H    1 
ATOM   500  H HA2  . GLY A 1 33  ? 39.72333 15.64043  -5.38701  1.000 21.24881  ? 28  GLY A HA2  1 
ATOM   501  H HA3  . GLY A 1 33  ? 38.98335 14.83786  -6.52840  1.000 21.24881  ? 28  GLY A HA3  1 
ATOM   502  N N    . ALA A 1 34  ? 37.36751 17.16528  -6.86853  1.000 16.43314  ? 29  ALA A N    1 
ATOM   503  C CA   . ALA A 1 34  ? 37.02779 18.47008  -7.42201  1.000 14.11490  ? 29  ALA A CA   1 
ATOM   504  C C    . ALA A 1 34  ? 37.34939 19.59060  -6.43649  1.000 22.78802  ? 29  ALA A C    1 
ATOM   505  O O    . ALA A 1 34  ? 37.91429 20.63644  -6.80935  1.000 19.02736  ? 29  ALA A O    1 
ATOM   506  C CB   . ALA A 1 34  ? 35.54400 18.49438  -7.80034  1.000 9.59812   ? 29  ALA A CB   1 
ATOM   507  H H    . ALA A 1 34  ? 36.69393 16.64962  -6.72713  1.000 19.74217  ? 29  ALA A H    1 
ATOM   508  H HA   . ALA A 1 34  ? 37.55314 18.62004  -8.22352  1.000 16.96028  ? 29  ALA A HA   1 
ATOM   509  H HB1  . ALA A 1 34  ? 35.02239 18.15890  -7.05450  1.000 11.54014  ? 29  ALA A HB1  1 
ATOM   510  H HB2  . ALA A 1 34  ? 35.28432 19.40705  -8.00161  1.000 11.54014  ? 29  ALA A HB2  1 
ATOM   511  H HB3  . ALA A 1 34  ? 35.40738 17.93224  -8.57894  1.000 11.54014  ? 29  ALA A HB3  1 
ATOM   512  N N    . VAL A 1 35  ? 36.95574 19.40901  -5.17411  1.000 13.76917  ? 30  VAL A N    1 
ATOM   513  C CA   . VAL A 1 35  ? 37.23735 20.43091  -4.16427  1.000 17.38522  ? 30  VAL A CA   1 
ATOM   514  C C    . VAL A 1 35  ? 38.72736 20.73785  -4.12514  1.000 7.38624   ? 30  VAL A C    1 
ATOM   515  O O    . VAL A 1 35  ? 39.13846 21.90288  -4.10250  1.000 16.61807  ? 30  VAL A O    1 
ATOM   516  C CB   . VAL A 1 35  ? 36.73798 19.98050  -2.77912  1.000 12.57836  ? 30  VAL A CB   1 
ATOM   517  C CG1  . VAL A 1 35  ? 37.43846 20.79152  -1.72588  1.000 8.43069   ? 30  VAL A CG1  1 
ATOM   518  C CG2  . VAL A 1 35  ? 35.19769 20.07950  -2.64161  1.000 9.74843   ? 30  VAL A CG2  1 
ATOM   519  H H    . VAL A 1 35  ? 36.53354 18.71882  -4.88258  1.000 16.54541  ? 30  VAL A H    1 
ATOM   520  H HA   . VAL A 1 35  ? 36.76101 21.23861  -4.41249  1.000 20.88467  ? 30  VAL A HA   1 
ATOM   521  H HB   . VAL A 1 35  ? 36.94844 19.04141  -2.65779  1.000 15.11643  ? 30  VAL A HB   1 
ATOM   522  H HG11 . VAL A 1 35  ? 37.59190 21.68663  -2.06666  1.000 10.13923  ? 30  VAL A HG11 1 
ATOM   523  H HG12 . VAL A 1 35  ? 36.87990 20.83037  -0.93379  1.000 10.13923  ? 30  VAL A HG12 1 
ATOM   524  H HG13 . VAL A 1 35  ? 38.28523 20.36891  -1.51310  1.000 10.13923  ? 30  VAL A HG13 1 
ATOM   525  H HG21 . VAL A 1 35  ? 34.94764 19.86495  -1.72928  1.000 11.72052  ? 30  VAL A HG21 1 
ATOM   526  H HG22 . VAL A 1 35  ? 34.91882 20.98318  -2.85722  1.000 11.72052  ? 30  VAL A HG22 1 
ATOM   527  H HG23 . VAL A 1 35  ? 34.78489 19.45089  -3.25426  1.000 11.72052  ? 30  VAL A HG23 1 
ATOM   528  N N    . GLU A 1 36  ? 39.56636 19.69023  -4.11431  1.000 15.48902  ? 31  GLU A N    1 
ATOM   529  C CA   . GLU A 1 36  ? 41.01414 19.87172  -3.98933  1.000 4.91965   ? 31  GLU A CA   1 
ATOM   530  C C    . GLU A 1 36  ? 41.66164 20.55009  -5.19295  1.000 18.33338  ? 31  GLU A C    1 
ATOM   531  O O    . GLU A 1 36  ? 42.85266 20.88327  -5.11087  1.000 22.55229  ? 31  GLU A O    1 
ATOM   532  C CB   . GLU A 1 36  ? 41.66507 18.52398  -3.68544  1.000 21.02038  ? 31  GLU A CB   1 
ATOM   533  C CG   . GLU A 1 36  ? 41.67746 18.18560  -2.15063  1.000 17.05710  ? 31  GLU A CG   1 
ATOM   534  C CD   . GLU A 1 36  ? 41.73853 16.69058  -1.82061  1.000 16.10386  ? 31  GLU A CD   1 
ATOM   535  O OE1  . GLU A 1 36  ? 42.19516 15.86742  -2.65486  1.000 24.56060  ? 31  GLU A OE1  1 
ATOM   536  O OE2  . GLU A 1 36  ? 41.33477 16.34220  -0.70927  1.000 18.16615  ? 31  GLU A OE2  1 
ATOM   537  H H    . GLU A 1 36  ? 39.31976 18.86880  -4.17785  1.000 18.60922  ? 31  GLU A H    1 
ATOM   538  H HA   . GLU A 1 36  ? 41.19421 20.45975  -3.23921  1.000 5.92598   ? 31  GLU A HA   1 
ATOM   539  H HB2  . GLU A 1 36  ? 41.17186 17.82515  -4.14291  1.000 25.24686  ? 31  GLU A HB2  1 
ATOM   540  H HB3  . GLU A 1 36  ? 42.58363 18.53996  -3.99672  1.000 25.24686  ? 31  GLU A HB3  1 
ATOM   541  H HG2  . GLU A 1 36  ? 42.45514 18.60405  -1.74935  1.000 20.49092  ? 31  GLU A HG2  1 
ATOM   542  H HG3  . GLU A 1 36  ? 40.86732 18.53886  -1.75090  1.000 20.49092  ? 31  GLU A HG3  1 
ATOM   543  N N    . LYS A 1 37  ? 40.90388 20.82121  -6.27041  1.000 10.59712  ? 32  LYS A N    1 
ATOM   544  C CA   . LYS A 1 37  ? 41.41313 21.63026  -7.38379  1.000 31.80618  ? 32  LYS A CA   1 
ATOM   545  C C    . LYS A 1 37  ? 41.63790 23.10137  -7.03494  1.000 22.41772  ? 32  LYS A C    1 
ATOM   546  O O    . LYS A 1 37  ? 42.31601 23.80817  -7.79526  1.000 12.38587  ? 32  LYS A O    1 
ATOM   547  C CB   . LYS A 1 37  ? 40.46168 21.57553  -8.57764  1.000 17.49567  ? 32  LYS A CB   1 
ATOM   548  C CG   . LYS A 1 37  ? 40.38073 20.23694  -9.22689  1.000 28.49357  ? 32  LYS A CG   1 
ATOM   549  C CD   . LYS A 1 37  ? 41.67704 19.89213  -9.89794  1.000 18.10842  ? 32  LYS A CD   1 
ATOM   550  C CE   . LYS A 1 37  ? 41.51014 18.63419  -10.79482 1.000 26.78566  ? 32  LYS A CE   1 
ATOM   551  N NZ   . LYS A 1 37  ? 42.68896 17.70870  -10.78540 1.000 30.54330  ? 32  LYS A NZ   1 
ATOM   552  H H    . LYS A 1 37  ? 40.09544 20.54829  -6.37785  1.000 12.73894  ? 32  LYS A H    1 
ATOM   553  H HA   . LYS A 1 37  ? 42.26641 21.24041  -7.63040  1.000 38.18981  ? 32  LYS A HA   1 
ATOM   554  H HB2  . LYS A 1 37  ? 39.57052 21.81166  -8.27605  1.000 21.01720  ? 32  LYS A HB2  1 
ATOM   555  H HB3  . LYS A 1 37  ? 40.76468 22.20989  -9.24599  1.000 21.01720  ? 32  LYS A HB3  1 
ATOM   556  H HG2  . LYS A 1 37  ? 40.19225 19.56219  -8.55600  1.000 34.21469  ? 32  LYS A HG2  1 
ATOM   557  H HG3  . LYS A 1 37  ? 39.67936 20.24359  -9.89692  1.000 34.21469  ? 32  LYS A HG3  1 
ATOM   558  H HD2  . LYS A 1 37  ? 41.96139 20.63324  -10.45543 1.000 21.75250  ? 32  LYS A HD2  1 
ATOM   559  H HD3  . LYS A 1 37  ? 42.35095 19.70489  -9.22586  1.000 21.75250  ? 32  LYS A HD3  1 
ATOM   560  H HE2  . LYS A 1 37  ? 40.74061 18.13176  -10.48453 1.000 32.16519  ? 32  LYS A HE2  1 
ATOM   561  H HE3  . LYS A 1 37  ? 41.37101 18.92224  -11.71055 1.000 32.16519  ? 32  LYS A HE3  1 
ATOM   562  H HZ1  . LYS A 1 37  ? 42.56059 17.04633  -11.36583 1.000 36.67436  ? 32  LYS A HZ1  1 
ATOM   563  H HZ2  . LYS A 1 37  ? 43.42628 18.15259  -11.01214 1.000 36.67436  ? 32  LYS A HZ2  1 
ATOM   564  H HZ3  . LYS A 1 37  ? 42.79827 17.36326  -9.97249  1.000 36.67436  ? 32  LYS A HZ3  1 
ATOM   565  N N    . GLY A 1 38  ? 41.08740 23.59225  -5.92616  1.000 23.52090  ? 33  GLY A N    1 
ATOM   566  C CA   . GLY A 1 38  ? 41.42286 24.92216  -5.43543  1.000 14.67135  ? 33  GLY A CA   1 
ATOM   567  C C    . GLY A 1 38  ? 40.43030 26.03521  -5.78983  1.000 23.70278  ? 33  GLY A C    1 
ATOM   568  O O    . GLY A 1 38  ? 40.59570 27.17321  -5.30427  1.000 22.77560  ? 33  GLY A O    1 
ATOM   569  H H    . GLY A 1 38  ? 40.51562 23.17090  -5.44125  1.000 28.24748  ? 33  GLY A H    1 
ATOM   570  H HA2  . GLY A 1 38  ? 41.48626 24.88527  -4.46821  1.000 17.62802  ? 33  GLY A HA2  1 
ATOM   571  H HA3  . GLY A 1 38  ? 42.28595 25.17463  -5.79908  1.000 17.62802  ? 33  GLY A HA3  1 
ATOM   572  N N    . GLU A 1 39  ? 39.40658 25.76205  -6.60219  1.000 24.14876  ? 34  GLU A N    1 
ATOM   573  C CA   . GLU A 1 39  ? 38.44183 26.79154  -6.98721  1.000 17.53004  ? 34  GLU A CA   1 
ATOM   574  C C    . GLU A 1 39  ? 37.13862 26.66532  -6.19709  1.000 23.25865  ? 34  GLU A C    1 
ATOM   575  O O    . GLU A 1 39  ? 36.77029 25.59069  -5.71810  1.000 25.70758  ? 34  GLU A O    1 
ATOM   576  C CB   . GLU A 1 39  ? 38.11891 26.73091  -8.47986  1.000 15.13092  ? 34  GLU A CB   1 
ATOM   577  C CG   . GLU A 1 39  ? 39.30573 26.57581  -9.39813  1.000 23.84748  ? 34  GLU A CG   1 
ATOM   578  C CD   . GLU A 1 39  ? 39.81903 27.91026  -9.92822  1.000 50.73107  ? 34  GLU A CD   1 
ATOM   579  O OE1  . GLU A 1 39  ? 38.99171 28.82193  -10.10603 1.000 47.52094  ? 34  GLU A OE1  1 
ATOM   580  O OE2  . GLU A 1 39  ? 41.04958 28.04920  -10.16741 1.000 46.74782  ? 34  GLU A OE2  1 
ATOM   581  H H    . GLU A 1 39  ? 39.25113 24.98760  -6.94229  1.000 29.00091  ? 34  GLU A H    1 
ATOM   582  H HA   . GLU A 1 39  ? 38.83833 27.65396  -6.78741  1.000 21.05845  ? 34  GLU A HA   1 
ATOM   583  H HB2  . GLU A 1 39  ? 37.53398 25.97270  -8.63437  1.000 18.17951  ? 34  GLU A HB2  1 
ATOM   584  H HB3  . GLU A 1 39  ? 37.66838 27.55341  -8.72765  1.000 18.17951  ? 34  GLU A HB3  1 
ATOM   585  H HG2  . GLU A 1 39  ? 40.02800 26.14829  -8.91187  1.000 28.63938  ? 34  GLU A HG2  1 
ATOM   586  H HG3  . GLU A 1 39  ? 39.04860 26.03012  -10.15774 1.000 28.63938  ? 34  GLU A HG3  1 
ATOM   587  N N    . GLU A 1 40  ? 36.43885 27.78219  -6.06480  1.000 22.30306  ? 35  GLU A N    1 
ATOM   588  C CA   . GLU A 1 40  ? 35.18694 27.77889  -5.32061  1.000 19.52926  ? 35  GLU A CA   1 
ATOM   589  C C    . GLU A 1 40  ? 34.15333 26.95044  -6.08712  1.000 19.55795  ? 35  GLU A C    1 
ATOM   590  O O    . GLU A 1 40  ? 34.31408 26.67539  -7.27200  1.000 13.92708  ? 35  GLU A O    1 
ATOM   591  C CB   . GLU A 1 40  ? 34.71881 29.23778  -5.06115  1.000 25.80044  ? 35  GLU A CB   1 
ATOM   592  C CG   . GLU A 1 40  ? 35.76483 30.14814  -4.30587  1.000 44.03126  ? 35  GLU A CG   1 
ATOM   593  C CD   . GLU A 1 40  ? 35.34199 31.63447  -4.03425  1.000 49.05266  ? 35  GLU A CD   1 
ATOM   594  O OE1  . GLU A 1 40  ? 34.13327 31.94130  -3.99464  1.000 52.86697  ? 35  GLU A OE1  1 
ATOM   595  O OE2  . GLU A 1 40  ? 36.22999 32.50962  -3.82379  1.000 32.26906  ? 35  GLU A OE2  1 
ATOM   596  H H    . GLU A 1 40  ? 36.66272 28.54564  -6.39133  1.000 26.78607  ? 35  GLU A H    1 
ATOM   597  H HA   . GLU A 1 40  ? 35.28865 27.37206  -4.44594  1.000 23.45751  ? 35  GLU A HA   1 
ATOM   598  H HB2  . GLU A 1 40  ? 34.53158 29.65692  -5.91565  1.000 30.98293  ? 35  GLU A HB2  1 
ATOM   599  H HB3  . GLU A 1 40  ? 33.91331 29.21057  -4.52140  1.000 30.98293  ? 35  GLU A HB3  1 
ATOM   600  H HG2  . GLU A 1 40  ? 35.94728 29.74400  -3.44315  1.000 52.85991  ? 35  GLU A HG2  1 
ATOM   601  H HG3  . GLU A 1 40  ? 36.57617 30.17756  -4.83668  1.000 52.85991  ? 35  GLU A HG3  1 
ATOM   602  N N    . LEU A 1 41  ? 33.07185 26.56697  -5.39166  1.000 23.68086  ? 36  LEU A N    1 
ATOM   603  C CA   . LEU A 1 41  ? 31.98904 25.76779  -5.94707  1.000 16.24584  ? 36  LEU A CA   1 
ATOM   604  C C    . LEU A 1 41  ? 30.71061 26.57080  -6.12204  1.000 28.33313  ? 36  LEU A C    1 
ATOM   605  O O    . LEU A 1 41  ? 30.31264 27.30501  -5.22055  1.000 11.15199  ? 36  LEU A O    1 
ATOM   606  C CB   . LEU A 1 41  ? 31.58951 24.57395  -5.07339  1.000 14.54607  ? 36  LEU A CB   1 
ATOM   607  C CG   . LEU A 1 41  ? 32.53462 23.69725  -4.23787  1.000 28.80069  ? 36  LEU A CG   1 
ATOM   608  C CD1  . LEU A 1 41  ? 31.71086 22.50116  -3.69608  1.000 16.10981  ? 36  LEU A CD1  1 
ATOM   609  C CD2  . LEU A 1 41  ? 33.78751 23.20628  -4.93406  1.000 10.80939  ? 36  LEU A CD2  1 
ATOM   610  H H    . LEU A 1 41  ? 32.94586 26.76952  -4.56541  1.000 28.43944  ? 36  LEU A H    1 
ATOM   611  H HA   . LEU A 1 41  ? 32.33002 25.46459  -6.80305  1.000 19.51741  ? 36  LEU A HA   1 
ATOM   612  H HB2  . LEU A 1 41  ? 30.95362 24.92353  -4.42970  1.000 17.47769  ? 36  LEU A HB2  1 
ATOM   613  H HB3  . LEU A 1 41  ? 31.14795 23.95023  -5.67080  1.000 17.47769  ? 36  LEU A HB3  1 
ATOM   614  H HG   . LEU A 1 41  ? 32.88581 24.25659  -3.52745  1.000 34.58323  ? 36  LEU A HG   1 
ATOM   615  H HD11 . LEU A 1 41  ? 32.31547 21.85667  -3.29610  1.000 19.35417  ? 36  LEU A HD11 1 
ATOM   616  H HD12 . LEU A 1 41  ? 31.08461 22.82498  -3.02985  1.000 19.35417  ? 36  LEU A HD12 1 
ATOM   617  H HD13 . LEU A 1 41  ? 31.22901 22.09079  -4.43114  1.000 19.35417  ? 36  LEU A HD13 1 
ATOM   618  H HD21 . LEU A 1 41  ? 33.53711 22.57552  -5.62712  1.000 12.99367  ? 36  LEU A HD21 1 
ATOM   619  H HD22 . LEU A 1 41  ? 34.24792 23.96415  -5.32719  1.000 12.99367  ? 36  LEU A HD22 1 
ATOM   620  H HD23 . LEU A 1 41  ? 34.36094 22.77218  -4.28320  1.000 12.99367  ? 36  LEU A HD23 1 
ATOM   621  N N    . SER A 1 42  ? 30.03150 26.33157  -7.24878  1.000 15.03301  ? 37  SER A N    1 
ATOM   622  C CA   . SER A 1 42  ? 28.70770 26.85495  -7.51909  1.000 19.75134  ? 37  SER A CA   1 
ATOM   623  C C    . SER A 1 42  ? 27.58690 26.23312  -6.66910  1.000 21.41880  ? 37  SER A C    1 
ATOM   624  O O    . SER A 1 42  ? 27.82349 25.36144  -5.82922  1.000 17.30607  ? 37  SER A O    1 
ATOM   625  C CB   . SER A 1 42  ? 28.40318 26.65442  -9.01246  1.000 19.55017  ? 37  SER A CB   1 
ATOM   626  O OG   . SER A 1 42  ? 28.38572 25.29667  -9.37382  1.000 14.96624  ? 37  SER A OG   1 
ATOM   627  H H    . SER A 1 42  ? 30.33544 25.84881  -7.89233  1.000 18.06202  ? 37  SER A H    1 
ATOM   628  H HA   . SER A 1 42  ? 28.70520 27.79646  -7.28571  1.000 23.72401  ? 37  SER A HA   1 
ATOM   629  H HB2  . SER A 1 42  ? 27.53355 27.03811  -9.20595  1.000 23.48260  ? 37  SER A HB2  1 
ATOM   630  H HB3  . SER A 1 42  ? 29.08751 27.10485  -9.53179  1.000 23.48260  ? 37  SER A HB3  1 
ATOM   631  H HG   . SER A 1 42  ? 28.30880 25.22208  -10.20696 1.000 17.98189  ? 37  SER A HG   1 
HETATM 632  N N    A CSO A 1 43  ? 26.36396 26.71807  -6.88199  0.342 14.54722  ? 38  CSO A N    1 
HETATM 633  N N    B CSO A 1 43  ? 26.35891 26.66951  -6.89663  0.658 15.58709  ? 38  CSO A N    1 
HETATM 634  C CA   A CSO A 1 43  ? 25.22039 26.25815  -6.11390  0.342 14.15342  ? 38  CSO A CA   1 
HETATM 635  C CA   B CSO A 1 43  ? 25.27835 26.26965  -6.02379  0.658 14.12613  ? 38  CSO A CA   1 
HETATM 636  C CB   A CSO A 1 43  ? 23.91743 26.93665  -6.55063  0.342 19.25291  ? 38  CSO A CB   1 
HETATM 637  C CB   B CSO A 1 43  ? 24.11824 27.28264  -6.13658  0.658 17.53099  ? 38  CSO A CB   1 
HETATM 638  S SG   A CSO A 1 43  ? 22.51308 25.90541  -5.99645  0.342 25.46113  ? 38  CSO A SG   1 
HETATM 639  S SG   B CSO A 1 43  ? 22.48071 26.60533  -5.67534  0.658 17.71086  ? 38  CSO A SG   1 
HETATM 640  C C    A CSO A 1 43  ? 25.06526 24.75665  -6.28986  0.342 19.29058  ? 38  CSO A C    1 
HETATM 641  C C    B CSO A 1 43  ? 24.83469 24.82045  -6.31566  0.658 19.51925  ? 38  CSO A C    1 
HETATM 642  O O    A CSO A 1 43  ? 25.02754 23.99704  -5.31784  0.342 19.72734  ? 38  CSO A O    1 
HETATM 643  O O    B CSO A 1 43  ? 24.35666 24.13603  -5.40226  0.658 20.12269  ? 38  CSO A O    1 
HETATM 644  O OD   A CSO A 1 43  ? 21.50505 25.28999  -7.33429  0.342 18.89891  ? 38  CSO A OD   1 
HETATM 645  O OD   B CSO A 1 43  ? 21.97489 27.05085  -4.03560  0.658 14.20557  ? 38  CSO A OD   1 
HETATM 646  H H    A CSO A 1 43  ? 26.17462 27.31688  -7.46951  0.342 17.47907  ? 38  CSO A H    1 
HETATM 647  H H    B CSO A 1 43  ? 26.13221 27.19081  -7.54196  0.658 18.72691  ? 38  CSO A H    1 
HETATM 648  H HA   A CSO A 1 43  ? 25.36657 26.48715  -5.17231  0.342 17.00650  ? 38  CSO A HA   1 
HETATM 649  H HA   B CSO A 1 43  ? 25.57027 26.27786  -5.08832  0.658 16.97376  ? 38  CSO A HA   1 
HETATM 650  H HB2  A CSO A 1 43  ? 23.89076 27.01580  -7.51703  0.342 23.12589  ? 38  CSO A HB2  1 
HETATM 651  H HB2  B CSO A 1 43  ? 24.06030 27.58835  -7.05532  0.658 21.05958  ? 38  CSO A HB2  1 
HETATM 652  H HB3  A CSO A 1 43  ? 23.84629 27.81432  -6.14379  0.342 23.12589  ? 38  CSO A HB3  1 
HETATM 653  H HB3  B CSO A 1 43  ? 24.30121 28.03203  -5.54849  0.658 21.05958  ? 38  CSO A HB3  1 
HETATM 654  H HD   A CSO A 1 43  ? 20.79097 24.73505  -6.98351  0.342 22.70109  ? 38  CSO A HD   1 
HETATM 655  H HD   B CSO A 1 43  ? 21.08400 26.71014  -3.85915  0.658 17.06909  ? 38  CSO A HD   1 
ATOM   656  N N    . GLU A 1 44  ? 25.02345 24.33533  -7.54800  1.000 23.91051  ? 39  GLU A N    1 
ATOM   657  C CA   . GLU A 1 44  ? 24.63984 22.95254  -7.89642  1.000 23.48100  ? 39  GLU A CA   1 
ATOM   658  C C    . GLU A 1 44  ? 25.73277 21.99880  -7.41586  1.000 13.04737  ? 39  GLU A C    1 
ATOM   659  O O    . GLU A 1 44  ? 25.45101 20.94106  -6.88034  1.000 18.12934  ? 39  GLU A O    1 
ATOM   660  C CB   . GLU A 1 44  ? 24.42728 22.78636  -9.39965  1.000 19.26303  ? 39  GLU A CB   1 
ATOM   661  C CG   . GLU A 1 44  ? 24.57991 21.33807  -9.94246  1.000 43.02226  ? 39  GLU A CG   1 
ATOM   662  C CD   . GLU A 1 44  ? 24.52953 21.21653  -11.49414 1.000 54.87761  ? 39  GLU A CD   1 
ATOM   663  O OE1  . GLU A 1 44  ? 25.55097 21.47045  -12.18712 1.000 50.01522  ? 39  GLU A OE1  1 
ATOM   664  O OE2  . GLU A 1 44  ? 23.46271 20.83034  -12.01572 1.000 45.80701  ? 39  GLU A OE2  1 
ATOM   665  H H    . GLU A 1 44  ? 25.36879 24.77998  -8.19810  1.000 28.71501  ? 39  GLU A H    1 
ATOM   666  H HA   . GLU A 1 44  ? 23.79625 22.73295  -7.47094  1.000 28.19960  ? 39  GLU A HA   1 
ATOM   667  H HB2  . GLU A 1 44  ? 23.52881 23.08184  -9.61490  1.000 23.13804  ? 39  GLU A HB2  1 
ATOM   668  H HB3  . GLU A 1 44  ? 25.07761 23.33775  -9.86219  1.000 23.13804  ? 39  GLU A HB3  1 
ATOM   669  H HG2  . GLU A 1 44  ? 25.43573 20.98741  -9.65003  1.000 51.64911  ? 39  GLU A HG2  1 
ATOM   670  H HG3  . GLU A 1 44  ? 23.85947 20.79651  -9.58389  1.000 51.64911  ? 39  GLU A HG3  1 
ATOM   671  N N    . GLU A 1 45  ? 26.98213 22.40243  -7.63208  1.000 18.26446  ? 40  GLU A N    1 
ATOM   672  C CA   . GLU A 1 45  ? 28.12571 21.60809  -7.18741  1.000 9.71516   ? 40  GLU A CA   1 
ATOM   673  C C    . GLU A 1 45  ? 28.14840 21.44685  -5.65987  1.000 21.09516  ? 40  GLU A C    1 
ATOM   674  O O    . GLU A 1 45  ? 28.64221 20.43381  -5.15666  1.000 15.71912  ? 40  GLU A O    1 
ATOM   675  C CB   . GLU A 1 45  ? 29.44058 22.26361  -7.69868  1.000 24.62570  ? 40  GLU A CB   1 
ATOM   676  C CG   . GLU A 1 45  ? 29.65179 22.31054  -9.25569  1.000 15.43513  ? 40  GLU A CG   1 
ATOM   677  C CD   . GLU A 1 45  ? 30.70850 23.36511  -9.73605  1.000 18.38471  ? 40  GLU A CD   1 
ATOM   678  O OE1  . GLU A 1 45  ? 31.21197 24.15769  -8.92603  1.000 17.77234  ? 40  GLU A OE1  1 
ATOM   679  O OE2  . GLU A 1 45  ? 31.04239 23.39182  -10.93604 1.000 20.72469  ? 40  GLU A OE2  1 
ATOM   680  H H    . GLU A 1 45  ? 27.19687 23.13193  -8.03373  1.000 21.93976  ? 40  GLU A H    1 
ATOM   681  H HA   . GLU A 1 45  ? 28.06536 20.71793  -7.56803  1.000 11.68060  ? 40  GLU A HA   1 
ATOM   682  H HB2  . GLU A 1 45  ? 29.46092 23.18049  -7.38275  1.000 29.57324  ? 40  GLU A HB2  1 
ATOM   683  H HB3  . GLU A 1 45  ? 30.18688 21.76794  -7.32685  1.000 29.57324  ? 40  GLU A HB3  1 
ATOM   684  H HG2  . GLU A 1 45  ? 29.95282 21.43791  -9.55367  1.000 18.54456  ? 40  GLU A HG2  1 
ATOM   685  H HG3  . GLU A 1 45  ? 28.80603 22.53118  -9.67628  1.000 18.54456  ? 40  GLU A HG3  1 
ATOM   686  N N    . ARG A 1 46  ? 27.61911 22.42291  -4.90384  1.000 15.50194  ? 41  ARG A N    1 
ATOM   687  C CA   . ARG A 1 46  ? 27.58546 22.29582  -3.45853  1.000 7.58197   ? 41  ARG A CA   1 
ATOM   688  C C    . ARG A 1 46  ? 26.57752 21.24250  -3.02982  1.000 15.93577  ? 41  ARG A C    1 
ATOM   689  O O    . ARG A 1 46  ? 26.82066 20.47938  -2.08845  1.000 20.50766  ? 41  ARG A O    1 
ATOM   690  C CB   . ARG A 1 46  ? 27.22928 23.64343  -2.80340  1.000 14.48104  ? 41  ARG A CB   1 
ATOM   691  C CG   . ARG A 1 46  ? 28.32651 24.67352  -2.79519  1.000 18.98147  ? 41  ARG A CG   1 
ATOM   692  C CD   . ARG A 1 46  ? 28.00644 25.78172  -1.83194  1.000 16.03067  ? 41  ARG A CD   1 
ATOM   693  N NE   . ARG A 1 46  ? 26.82255 26.54346  -2.22938  1.000 20.57192  ? 41  ARG A NE   1 
ATOM   694  C CZ   . ARG A 1 46  ? 26.83786 27.61000  -3.02143  1.000 23.82659  ? 41  ARG A CZ   1 
ATOM   695  N NH1  . ARG A 1 46  ? 27.94301 28.01275  -3.63515  1.000 19.60158  ? 41  ARG A NH1  1 
ATOM   696  N NH2  . ARG A 1 46  ? 25.71526 28.30050  -3.19449  1.000 27.26244  ? 41  ARG A NH2  1 
ATOM   697  H H    . ARG A 1 46  ? 27.28096 23.15299  -5.20754  1.000 18.62473  ? 41  ARG A H    1 
ATOM   698  H HA   . ARG A 1 46  ? 28.46922 22.03419  -3.15620  1.000 9.12076   ? 41  ARG A HA   1 
ATOM   699  H HB2  . ARG A 1 46  ? 26.47829 24.02626  -3.28335  1.000 17.39965  ? 41  ARG A HB2  1 
ATOM   700  H HB3  . ARG A 1 46  ? 26.98303 23.47743  -1.87998  1.000 17.39965  ? 41  ARG A HB3  1 
ATOM   701  H HG2  . ARG A 1 46  ? 29.15938 24.25825  -2.52175  1.000 22.80017  ? 41  ARG A HG2  1 
ATOM   702  H HG3  . ARG A 1 46  ? 28.42109 25.05391  -3.68246  1.000 22.80017  ? 41  ARG A HG3  1 
ATOM   703  H HD2  . ARG A 1 46  ? 27.83953 25.40181  -0.95518  1.000 19.25921  ? 41  ARG A HD2  1 
ATOM   704  H HD3  . ARG A 1 46  ? 28.75810 26.39345  -1.79082  1.000 19.25921  ? 41  ARG A HD3  1 
ATOM   705  H HE   . ARG A 1 46  ? 26.06072 26.28170  -1.92823  1.000 24.70870  ? 41  ARG A HE   1 
ATOM   706  H HH11 . ARG A 1 46  ? 28.67788 27.57966  -3.52561  1.000 23.54430  ? 41  ARG A HH11 1 
ATOM   707  H HH12 . ARG A 1 46  ? 27.92451 28.70690  -4.14251  1.000 23.54430  ? 41  ARG A HH12 1 
ATOM   708  H HH21 . ARG A 1 46  ? 24.99358 28.05472  -2.79654  1.000 32.73733  ? 41  ARG A HH21 1 
ATOM   709  H HH22 . ARG A 1 46  ? 25.71066 28.99300  -3.70441  1.000 32.73733  ? 41  ARG A HH22 1 
ATOM   710  N N    . ASN A 1 47  ? 25.41943 21.20852  -3.68774  1.000 23.92898  ? 42  ASN A N    1 
ATOM   711  C CA   . ASN A 1 47  ? 24.43271 20.18104  -3.38063  1.000 12.61592  ? 42  ASN A CA   1 
ATOM   712  C C    . ASN A 1 47  ? 24.94638 18.77916  -3.69118  1.000 18.98928  ? 42  ASN A C    1 
ATOM   713  O O    . ASN A 1 47  ? 24.55317 17.84428  -3.00811  1.000 16.38715  ? 42  ASN A O    1 
ATOM   714  C CB   . ASN A 1 47  ? 23.13922 20.45001  -4.14972  1.000 31.08335  ? 42  ASN A CB   1 
ATOM   715  C CG   . ASN A 1 47  ? 22.24870 21.45832  -3.44531  1.000 39.20954  ? 42  ASN A CG   1 
ATOM   716  O OD1  . ASN A 1 47  ? 21.17029 21.12036  -2.98666  1.000 55.44647  ? 42  ASN A OD1  1 
ATOM   717  N ND2  . ASN A 1 47  ? 22.71177 22.70064  -3.33664  1.000 33.80228  ? 42  ASN A ND2  1 
ATOM   718  H H    . ASN A 1 47  ? 25.18578 21.75957  -4.30527  1.000 28.73717  ? 42  ASN A H    1 
ATOM   719  H HA   . ASN A 1 47  ? 24.23765 20.22018  -2.43125  1.000 15.16150  ? 42  ASN A HA   1 
ATOM   720  H HB2  . ASN A 1 47  ? 23.35824 20.80163  -5.02681  1.000 37.32242  ? 42  ASN A HB2  1 
ATOM   721  H HB3  . ASN A 1 47  ? 22.64421 19.62061  -4.23893  1.000 37.32242  ? 42  ASN A HB3  1 
ATOM   722  H HD21 . ASN A 1 47  ? 22.23923 23.30293  -2.94478  1.000 40.58514  ? 42  ASN A HD21 1 
ATOM   723  H HD22 . ASN A 1 47  ? 23.48367 22.90149  -3.65824  1.000 40.58514  ? 42  ASN A HD22 1 
ATOM   724  N N    . LEU A 1 48  ? 25.77214 18.60188  -4.74389  1.000 15.31247  ? 43  LEU A N    1 
ATOM   725  C CA   . LEU A 1 48  ? 26.32880 17.27972  -5.04492  1.000 14.78544  ? 43  LEU A CA   1 
ATOM   726  C C    . LEU A 1 48  ? 27.18697 16.78435  -3.87864  1.000 15.11021  ? 43  LEU A C    1 
ATOM   727  O O    . LEU A 1 48  ? 27.09768 15.62682  -3.44541  1.000 9.78775   ? 43  LEU A O    1 
ATOM   728  C CB   . LEU A 1 48  ? 27.18310 17.34544  -6.32254  1.000 18.67897  ? 43  LEU A CB   1 
ATOM   729  C CG   . LEU A 1 48  ? 26.45802 17.56293  -7.65479  1.000 23.96388  ? 43  LEU A CG   1 
ATOM   730  C CD1  . LEU A 1 48  ? 27.40375 17.71102  -8.85229  1.000 17.12919  ? 43  LEU A CD1  1 
ATOM   731  C CD2  . LEU A 1 48  ? 25.54310 16.43313  -7.85551  1.000 7.15395   ? 43  LEU A CD2  1 
ATOM   732  H H    . LEU A 1 48  ? 26.01743 19.22317  -5.28558  1.000 18.39736  ? 43  LEU A H    1 
ATOM   733  H HA   . LEU A 1 48  ? 25.59889 16.65819  -5.19270  1.000 17.76492  ? 43  LEU A HA   1 
ATOM   734  H HB2  . LEU A 1 48  ? 27.80935 18.07932  -6.22190  1.000 22.43717  ? 43  LEU A HB2  1 
ATOM   735  H HB3  . LEU A 1 48  ? 27.66439 16.50681  -6.39972  1.000 22.43717  ? 43  LEU A HB3  1 
ATOM   736  H HG   . LEU A 1 48  ? 25.97343 18.40223  -7.61412  1.000 28.77906  ? 43  LEU A HG   1 
ATOM   737  H HD11 . LEU A 1 48  ? 28.04028 18.41894  -8.66634  1.000 20.57743  ? 43  LEU A HD11 1 
ATOM   738  H HD12 . LEU A 1 48  ? 27.87214 16.87289  -8.99033  1.000 20.57743  ? 43  LEU A HD12 1 
ATOM   739  H HD13 . LEU A 1 48  ? 26.88327 17.93274  -9.64022  1.000 20.57743  ? 43  LEU A HD13 1 
ATOM   740  H HD21 . LEU A 1 48  ? 26.02102 15.60599  -7.68718  1.000 8.60714   ? 43  LEU A HD21 1 
ATOM   741  H HD22 . LEU A 1 48  ? 24.79864 16.51630  -7.23926  1.000 8.60714   ? 43  LEU A HD22 1 
ATOM   742  H HD23 . LEU A 1 48  ? 25.21902 16.44775  -8.76965  1.000 8.60714   ? 43  LEU A HD23 1 
ATOM   743  N N    . LEU A 1 49  ? 28.03941 17.66892  -3.37761  1.000 16.70530  ? 44  LEU A N    1 
ATOM   744  C CA   . LEU A 1 49  ? 28.89565 17.34937  -2.24855  1.000 14.62427  ? 44  LEU A CA   1 
ATOM   745  C C    . LEU A 1 49  ? 28.10158 16.94005  -1.00961  1.000 24.53026  ? 44  LEU A C    1 
ATOM   746  O O    . LEU A 1 49  ? 28.52008 16.02955  -0.29077  1.000 23.85990  ? 44  LEU A O    1 
ATOM   747  C CB   . LEU A 1 49  ? 29.76570 18.56393  -1.93795  1.000 6.68334   ? 44  LEU A CB   1 
ATOM   748  C CG   . LEU A 1 49  ? 30.76901 18.38401  -0.79121  1.000 18.73593  ? 44  LEU A CG   1 
ATOM   749  C CD1  . LEU A 1 49  ? 31.98140 17.52584  -1.24692  1.000 5.84383   ? 44  LEU A CD1  1 
ATOM   750  C CD2  . LEU A 1 49  ? 31.22370 19.74184  -0.22837  1.000 16.57560  ? 44  LEU A CD2  1 
ATOM   751  H H    . LEU A 1 49  ? 28.14210 18.46878  -3.67639  1.000 20.06875  ? 44  LEU A H    1 
ATOM   752  H HA   . LEU A 1 49  ? 29.45708 16.59496  -2.48639  1.000 17.57152  ? 44  LEU A HA   1 
ATOM   753  H HB2  . LEU A 1 49  ? 30.27345 18.78583  -2.73410  1.000 8.04240   ? 44  LEU A HB2  1 
ATOM   754  H HB3  . LEU A 1 49  ? 29.18339 19.30210  -1.69938  1.000 8.04240   ? 44  LEU A HB3  1 
ATOM   755  H HG   . LEU A 1 49  ? 30.32940 17.90907  -0.06866  1.000 22.50552  ? 44  LEU A HG   1 
ATOM   756  H HD11 . LEU A 1 49  ? 31.73831 16.58779  -1.20382  1.000 7.03500   ? 44  LEU A HD11 1 
ATOM   757  H HD12 . LEU A 1 49  ? 32.21369 17.76585  -2.15760  1.000 7.03500   ? 44  LEU A HD12 1 
ATOM   758  H HD13 . LEU A 1 49  ? 32.73147 17.70061  -0.65721  1.000 7.03500   ? 44  LEU A HD13 1 
ATOM   759  H HD21 . LEU A 1 49  ? 31.87610 19.59037  0.47329   1.000 19.91312  ? 44  LEU A HD21 1 
ATOM   760  H HD22 . LEU A 1 49  ? 31.62175 20.26274  -0.94330  1.000 19.91312  ? 44  LEU A HD22 1 
ATOM   761  H HD23 . LEU A 1 49  ? 30.45323 20.20853  0.13147   1.000 19.91312  ? 44  LEU A HD23 1 
ATOM   762  N N    . SER A 1 50  ? 26.97809 17.61488  -0.70785  1.000 17.42696  ? 45  SER A N    1 
ATOM   763  C CA   . SER A 1 50  ? 26.25090 17.26093  0.50940   1.000 31.32936  ? 45  SER A CA   1 
ATOM   764  C C    . SER A 1 50  ? 25.44726 15.98957  0.30906   1.000 16.96557  ? 45  SER A C    1 
ATOM   765  O O    . SER A 1 50  ? 25.31522 15.20047  1.23118   1.000 17.44732  ? 45  SER A O    1 
ATOM   766  C CB   . SER A 1 50  ? 25.30671 18.38273  0.99538   1.000 6.60915   ? 45  SER A CB   1 
ATOM   767  O OG   . SER A 1 50  ? 23.98667 18.11557  0.55393   1.000 42.34110  ? 45  SER A OG   1 
ATOM   768  H H    . SER A 1 50  ? 26.63647 18.25175  -1.17399  1.000 20.93476  ? 45  SER A H    1 
ATOM   769  H HA   . SER A 1 50  ? 26.90930 17.13891  1.21119   1.000 37.61764  ? 45  SER A HA   1 
ATOM   770  H HB2  . SER A 1 50  ? 25.32038 18.41627  1.96470   1.000 7.95337   ? 45  SER A HB2  1 
ATOM   771  H HB3  . SER A 1 50  ? 25.60180 19.23140  0.62986   1.000 7.95337   ? 45  SER A HB3  1 
ATOM   772  H HG   . SER A 1 50  ? 23.47190 18.73324  0.79702   1.000 50.83172  ? 45  SER A HG   1 
ATOM   773  N N    . VAL A 1 51  ? 24.91800 15.76310  -0.88937  1.000 21.34859  ? 46  VAL A N    1 
ATOM   774  C CA   . VAL A 1 51  ? 24.19967 14.51303  -1.14637  1.000 27.55274  ? 46  VAL A CA   1 
ATOM   775  C C    . VAL A 1 51  ? 25.13122 13.30697  -1.02793  1.000 22.94285  ? 46  VAL A C    1 
ATOM   776  O O    . VAL A 1 51  ? 24.72543 12.24835  -0.52072  1.000 17.11040  ? 46  VAL A O    1 
ATOM   777  C CB   . VAL A 1 51  ? 23.50834 14.56397  -2.52123  1.000 23.08853  ? 46  VAL A CB   1 
ATOM   778  C CG1  . VAL A 1 51  ? 22.93490 13.20228  -2.88046  1.000 26.35529  ? 46  VAL A CG1  1 
ATOM   779  C CG2  . VAL A 1 51  ? 22.37751 15.58231  -2.47430  1.000 21.37431  ? 46  VAL A CG2  1 
ATOM   780  H H    . VAL A 1 51  ? 24.95788 16.30253  -1.55797  1.000 25.64071  ? 46  VAL A H    1 
ATOM   781  H HA   . VAL A 1 51  ? 23.51378 14.41766  -0.46715  1.000 33.08569  ? 46  VAL A HA   1 
ATOM   782  H HB   . VAL A 1 51  ? 24.15786 14.81682  -3.19583  1.000 27.72864  ? 46  VAL A HB   1 
ATOM   783  H HG11 . VAL A 1 51  ? 22.38966 13.28964  -3.67794  1.000 31.64875  ? 46  VAL A HG11 1 
ATOM   784  H HG12 . VAL A 1 51  ? 23.66523 12.58549  -3.04502  1.000 31.64875  ? 46  VAL A HG12 1 
ATOM   785  H HG13 . VAL A 1 51  ? 22.39251 12.88329  -2.14224  1.000 31.64875  ? 46  VAL A HG13 1 
ATOM   786  H HG21 . VAL A 1 51  ? 22.03725 15.71800  -3.37247  1.000 25.67158  ? 46  VAL A HG21 1 
ATOM   787  H HG22 . VAL A 1 51  ? 21.67191 15.24449  -1.90079  1.000 25.67158  ? 46  VAL A HG22 1 
ATOM   788  H HG23 . VAL A 1 51  ? 22.71970 16.41813  -2.12043  1.000 25.67158  ? 46  VAL A HG23 1 
ATOM   789  N N    . ALA A 1 52  ? 26.39907 13.45099  -1.46172  1.000 15.14377  ? 47  ALA A N    1 
ATOM   790  C CA   . ALA A 1 52  ? 27.29638 12.29592  -1.51307  1.000 17.55863  ? 47  ALA A CA   1 
ATOM   791  C C    . ALA A 1 52  ? 27.73871 11.86671  -0.10519  1.000 17.44328  ? 47  ALA A C    1 
ATOM   792  O O    . ALA A 1 52  ? 27.53553 10.71015  0.28878   1.000 22.75166  ? 47  ALA A O    1 
ATOM   793  C CB   . ALA A 1 52  ? 28.49606 12.61219  -2.41285  1.000 20.44151  ? 47  ALA A CB   1 
ATOM   794  H H    . ALA A 1 52  ? 26.74966 14.19115  -1.72411  1.000 18.19493  ? 47  ALA A H    1 
ATOM   795  H HA   . ALA A 1 52  ? 26.82566 11.54354  -1.90454  1.000 21.09275  ? 47  ALA A HA   1 
ATOM   796  H HB1  . ALA A 1 52  ? 29.12898 11.87870  -2.36471  1.000 24.55221  ? 47  ALA A HB1  1 
ATOM   797  H HB2  . ALA A 1 52  ? 28.18607 12.72225  -3.32537  1.000 24.55221  ? 47  ALA A HB2  1 
ATOM   798  H HB3  . ALA A 1 52  ? 28.91473 13.43112  -2.10469  1.000 24.55221  ? 47  ALA A HB3  1 
ATOM   799  N N    . TYR A 1 53  ? 28.29144 12.79007  0.68875   1.000 9.70370   ? 48  TYR A N    1 
ATOM   800  C CA   . TYR A 1 53  ? 28.73327 12.44060  2.03633   1.000 17.10801  ? 48  TYR A CA   1 
ATOM   801  C C    . TYR A 1 53  ? 27.58423 12.15533  3.01956   1.000 24.35763  ? 48  TYR A C    1 
ATOM   802  O O    . TYR A 1 53  ? 27.81986 11.47382  4.01879   1.000 16.62976  ? 48  TYR A O    1 
ATOM   803  C CB   . TYR A 1 53  ? 29.66545 13.53776  2.60303   1.000 33.91956  ? 48  TYR A CB   1 
ATOM   804  C CG   . TYR A 1 53  ? 31.11320 13.43720  2.10061   1.000 24.09770  ? 48  TYR A CG   1 
ATOM   805  C CD1  . TYR A 1 53  ? 32.02623 12.52645  2.65278   1.000 8.06245   ? 48  TYR A CD1  1 
ATOM   806  C CD2  . TYR A 1 53  ? 31.55360 14.24937  1.05921   1.000 20.87462  ? 48  TYR A CD2  1 
ATOM   807  C CE1  . TYR A 1 53  ? 33.32626 12.43071  2.16690   1.000 8.48692   ? 48  TYR A CE1  1 
ATOM   808  C CE2  . TYR A 1 53  ? 32.86290 14.15889  0.57056   1.000 22.31678  ? 48  TYR A CE2  1 
ATOM   809  C CZ   . TYR A 1 53  ? 33.73607 13.24395  1.10711   1.000 19.76565  ? 48  TYR A CZ   1 
ATOM   810  O OH   . TYR A 1 53  ? 35.02480 13.18346  0.57453   1.000 17.94767  ? 48  TYR A OH   1 
ATOM   811  H H    . TYR A 1 53  ? 28.41877 13.61249  0.47194   1.000 11.66684  ? 48  TYR A H    1 
ATOM   812  H HA   . TYR A 1 53  ? 29.24514 11.61955  1.96727   1.000 20.55202  ? 48  TYR A HA   1 
ATOM   813  H HB2  . TYR A 1 53  ? 29.32063 14.40590  2.34164   1.000 40.72587  ? 48  TYR A HB2  1 
ATOM   814  H HB3  . TYR A 1 53  ? 29.68159 13.46468  3.57014   1.000 40.72587  ? 48  TYR A HB3  1 
ATOM   815  H HD1  . TYR A 1 53  ? 31.75827 11.97817  3.35455   1.000 9.69734   ? 48  TYR A HD1  1 
ATOM   816  H HD2  . TYR A 1 53  ? 30.96702 14.86384  0.68073   1.000 25.07194  ? 48  TYR A HD2  1 
ATOM   817  H HE1  . TYR A 1 53  ? 33.92194 11.82609  2.54704   1.000 10.20671  ? 48  TYR A HE1  1 
ATOM   818  H HE2  . TYR A 1 53  ? 33.14156 14.71871  -0.11781  1.000 26.80254  ? 48  TYR A HE2  1 
ATOM   819  H HH   . TYR A 1 53  ? 35.41638 12.49232  0.84764   1.000 21.55961  ? 48  TYR A HH   1 
ATOM   820  N N    . LYS A 1 54  ? 26.35123 12.61111  2.75281   1.000 22.88415  ? 49  LYS A N    1 
ATOM   821  C CA   . LYS A 1 54  ? 25.22629 12.30022  3.64004   1.000 20.05661  ? 49  LYS A CA   1 
ATOM   822  C C    . LYS A 1 54  ? 24.78136 10.84265  3.50812   1.000 19.57075  ? 49  LYS A C    1 
ATOM   823  O O    . LYS A 1 54  ? 24.52765 10.16316  4.51488   1.000 13.11196  ? 49  LYS A O    1 
ATOM   824  C CB   . LYS A 1 54  ? 24.03770 13.21918  3.33105   1.000 26.08275  ? 49  LYS A CB   1 
ATOM   825  C CG   . LYS A 1 54  ? 24.03139 14.52273  4.06948   1.000 59.51892  ? 49  LYS A CG   1 
ATOM   826  C CD   . LYS A 1 54  ? 25.42901 15.12073  4.08951   1.000 62.97933  ? 49  LYS A CD   1 
ATOM   827  C CE   . LYS A 1 54  ? 25.39863 16.60868  4.35043   1.000 52.40433  ? 49  LYS A CE   1 
ATOM   828  N NZ   . LYS A 1 54  ? 24.86911 16.84751  5.72737   1.000 77.79088  ? 49  LYS A NZ   1 
ATOM   829  H H    . LYS A 1 54  ? 26.14392 13.09571  2.07326   1.000 27.48339  ? 49  LYS A H    1 
ATOM   830  H HA   . LYS A 1 54  ? 25.52082 12.45294  4.55154   1.000 24.09034  ? 49  LYS A HA   1 
ATOM   831  H HB2  . LYS A 1 54  ? 24.04652 13.42300  2.38274   1.000 31.32170  ? 49  LYS A HB2  1 
ATOM   832  H HB3  . LYS A 1 54  ? 23.22027 12.75089  3.56214   1.000 31.32170  ? 49  LYS A HB3  1 
ATOM   833  H HG2  . LYS A 1 54  ? 23.43359 15.14550  3.62710   1.000 71.44511  ? 49  LYS A HG2  1 
ATOM   834  H HG3  . LYS A 1 54  ? 23.74241 14.37828  4.98410   1.000 71.44511  ? 49  LYS A HG3  1 
ATOM   835  H HD2  . LYS A 1 54  ? 25.94743 14.69963  4.79294   1.000 75.59759  ? 49  LYS A HD2  1 
ATOM   836  H HD3  . LYS A 1 54  ? 25.85340 14.97176  3.23009   1.000 75.59759  ? 49  LYS A HD3  1 
ATOM   837  H HE2  . LYS A 1 54  ? 26.29512 16.97395  4.28890   1.000 62.90760  ? 49  LYS A HE2  1 
ATOM   838  H HE3  . LYS A 1 54  ? 24.81757 17.04559  3.70826   1.000 62.90760  ? 49  LYS A HE3  1 
ATOM   839  H HZ1  . LYS A 1 54  ? 24.76069 17.72014  5.86470   1.000 93.37146  ? 49  LYS A HZ1  1 
ATOM   840  H HZ2  . LYS A 1 54  ? 24.08425 16.43979  5.82664   1.000 93.37146  ? 49  LYS A HZ2  1 
ATOM   841  H HZ3  . LYS A 1 54  ? 25.43883 16.52854  6.33217   1.000 93.37146  ? 49  LYS A HZ3  1 
ATOM   842  N N    . ASN A 1 55  ? 24.65445 10.35902  2.26323   1.000 12.03705  ? 50  ASN A N    1 
ATOM   843  C CA   . ASN A 1 55  ? 24.27742 8.96571   2.04078   1.000 28.39794  ? 50  ASN A CA   1 
ATOM   844  C C    . ASN A 1 55  ? 25.34181 7.99428   2.52995   1.000 5.52777   ? 50  ASN A C    1 
ATOM   845  O O    . ASN A 1 55  ? 25.00390 6.87045   2.90101   1.000 21.78840  ? 50  ASN A O    1 
ATOM   846  C CB   . ASN A 1 55  ? 23.97792 8.70686   0.55097   1.000 8.59619   ? 50  ASN A CB   1 
ATOM   847  C CG   . ASN A 1 55  ? 22.57630 9.19261   0.12823   1.000 17.53803  ? 50  ASN A CG   1 
ATOM   848  O OD1  . ASN A 1 55  ? 21.54519 8.67293   0.57198   1.000 42.08428  ? 50  ASN A OD1  1 
ATOM   849  N ND2  . ASN A 1 55  ? 22.54351 10.18078  -0.73186  1.000 15.19774  ? 50  ASN A ND2  1 
ATOM   850  H H    . ASN A 1 55  ? 24.78014 10.81356  1.54406   1.000 14.46686  ? 50  ASN A H    1 
ATOM   851  H HA   . ASN A 1 55  ? 23.46389 8.80015   2.54243   1.000 34.09992  ? 50  ASN A HA   1 
ATOM   852  H HB2  . ASN A 1 55  ? 24.63299 9.17623   0.01108   1.000 10.33782  ? 50  ASN A HB2  1 
ATOM   853  H HB3  . ASN A 1 55  ? 24.02870 7.75344   0.37976   1.000 10.33782  ? 50  ASN A HB3  1 
ATOM   854  H HD21 . ASN A 1 55  ? 21.78820 10.49098  -1.00183  1.000 18.25968  ? 50  ASN A HD21 1 
ATOM   855  H HD22 . ASN A 1 55  ? 23.27730 10.51906  -1.02634  1.000 18.25968  ? 50  ASN A HD22 1 
ATOM   856  N N    . VAL A 1 56  ? 26.61624 8.39652   2.56401   1.000 9.71950   ? 51  VAL A N    1 
ATOM   857  C CA   . VAL A 1 56  ? 27.67008 7.51013   3.05476   1.000 6.78839   ? 51  VAL A CA   1 
ATOM   858  C C    . VAL A 1 56  ? 27.64768 7.41987   4.57904   1.000 25.89154  ? 51  VAL A C    1 
ATOM   859  O O    . VAL A 1 56  ? 27.67759 6.33092   5.16656   1.000 11.87509  ? 51  VAL A O    1 
ATOM   860  C CB   . VAL A 1 56  ? 29.04268 7.99226   2.56397   1.000 10.89337  ? 51  VAL A CB   1 
ATOM   861  C CG1  . VAL A 1 56  ? 30.18584 7.23219   3.28103   1.000 10.62992  ? 51  VAL A CG1  1 
ATOM   862  C CG2  . VAL A 1 56  ? 29.15714 7.87538   1.03929   1.000 9.90973   ? 51  VAL A CG2  1 
ATOM   863  H H    . VAL A 1 56  ? 26.89255 9.17055   2.31075   1.000 11.68580  ? 51  VAL A H    1 
ATOM   864  H HA   . VAL A 1 56  ? 27.50333 6.62452   2.69588   1.000 8.16847   ? 51  VAL A HA   1 
ATOM   865  H HB   . VAL A 1 56  ? 29.13558 8.93174   2.78681   1.000 13.09445  ? 51  VAL A HB   1 
ATOM   866  H HG11 . VAL A 1 56  ? 30.98852 7.28453   2.73893   1.000 12.77831  ? 51  VAL A HG11 1 
ATOM   867  H HG12 . VAL A 1 56  ? 30.34355 7.64191   4.14599   1.000 12.77831  ? 51  VAL A HG12 1 
ATOM   868  H HG13 . VAL A 1 56  ? 29.92474 6.30520   3.39679   1.000 12.77831  ? 51  VAL A HG13 1 
ATOM   869  H HG21 . VAL A 1 56  ? 30.09454 7.89416   0.79061   1.000 11.91407  ? 51  VAL A HG21 1 
ATOM   870  H HG22 . VAL A 1 56  ? 28.75639 7.03878   0.75572   1.000 11.91407  ? 51  VAL A HG22 1 
ATOM   871  H HG23 . VAL A 1 56  ? 28.69122 8.62098   0.62953   1.000 11.91407  ? 51  VAL A HG23 1 
ATOM   872  N N    . VAL A 1 57  ? 27.65447 8.57375   5.24675   1.000 18.84377  ? 52  VAL A N    1 
ATOM   873  C CA   . VAL A 1 57  ? 27.56756 8.59586   6.70580   1.000 21.22175  ? 52  VAL A CA   1 
ATOM   874  C C    . VAL A 1 57  ? 26.21468 8.04029   7.15979   1.000 18.93803  ? 52  VAL A C    1 
ATOM   875  O O    . VAL A 1 57  ? 26.12766 7.34220   8.17007   1.000 26.25302  ? 52  VAL A O    1 
ATOM   876  C CB   . VAL A 1 57  ? 27.83859 10.02573  7.22578   1.000 29.34064  ? 52  VAL A CB   1 
ATOM   877  C CG1  . VAL A 1 57  ? 26.54734 10.81824  7.56410   1.000 24.71015  ? 52  VAL A CG1  1 
ATOM   878  C CG2  . VAL A 1 57  ? 28.71727 9.99116   8.45391   1.000 27.06053  ? 52  VAL A CG2  1 
ATOM   879  H H    . VAL A 1 57  ? 27.70804 9.35090   4.88238   1.000 22.63493  ? 52  VAL A H    1 
ATOM   880  H HA   . VAL A 1 57  ? 28.25172 8.01996   7.08151   1.000 25.48850  ? 52  VAL A HA   1 
ATOM   881  H HB   . VAL A 1 57  ? 28.28530 10.49051  6.50098   1.000 35.23117  ? 52  VAL A HB   1 
ATOM   882  H HG11 . VAL A 1 57  ? 26.05651 10.34314  8.25277   1.000 29.67458  ? 52  VAL A HG11 1 
ATOM   883  H HG12 . VAL A 1 57  ? 26.79287 11.70108  7.88224   1.000 29.67458  ? 52  VAL A HG12 1 
ATOM   884  H HG13 . VAL A 1 57  ? 26.00458 10.89418  6.76375   1.000 29.67458  ? 52  VAL A HG13 1 
ATOM   885  H HG21 . VAL A 1 57  ? 28.89497 10.90057  8.74077   1.000 32.49503  ? 52  VAL A HG21 1 
ATOM   886  H HG22 . VAL A 1 57  ? 28.25794 9.50622   9.15729   1.000 32.49503  ? 52  VAL A HG22 1 
ATOM   887  H HG23 . VAL A 1 57  ? 29.55001 9.54500   8.23396   1.000 32.49503  ? 52  VAL A HG23 1 
ATOM   888  N N    . GLY A 1 58  ? 25.15238 8.30156   6.40560   1.000 17.94565  ? 53  GLY A N    1 
ATOM   889  C CA   . GLY A 1 58  ? 23.85885 7.72458   6.75179   1.000 23.17714  ? 53  GLY A CA   1 
ATOM   890  C C    . GLY A 1 58  ? 23.88133 6.21595   6.94364   1.000 29.72380  ? 53  GLY A C    1 
ATOM   891  O O    . GLY A 1 58  ? 23.15883 5.68093   7.79793   1.000 25.79659  ? 53  GLY A O    1 
ATOM   892  H H    . GLY A 1 58  ? 25.15235 8.79843   5.70366   1.000 21.55718  ? 53  GLY A H    1 
ATOM   893  H HA2  . GLY A 1 58  ? 23.54721 8.12559   7.57820   1.000 27.83497  ? 53  GLY A HA2  1 
ATOM   894  H HA3  . GLY A 1 58  ? 23.22594 7.92581   6.04480   1.000 27.83497  ? 53  GLY A HA3  1 
ATOM   895  N N    . GLY A 1 59  ? 24.68879 5.50642   6.13615   1.000 29.00005  ? 54  GLY A N    1 
ATOM   896  C CA   . GLY A 1 59  ? 24.79254 4.05355   6.27780   1.000 20.50249  ? 54  GLY A CA   1 
ATOM   897  C C    . GLY A 1 59  ? 25.59334 3.62500   7.50488   1.000 26.86838  ? 54  GLY A C    1 
ATOM   898  O O    . GLY A 1 59  ? 25.24499 2.66058   8.19085   1.000 13.59793  ? 54  GLY A O    1 
ATOM   899  H H    . GLY A 1 59  ? 25.17649 5.83973   5.51113   1.000 34.82246  ? 54  GLY A H    1 
ATOM   900  H HA2  . GLY A 1 59  ? 23.90168 3.67694   6.35150   1.000 24.62539  ? 54  GLY A HA2  1 
ATOM   901  H HA3  . GLY A 1 59  ? 25.22601 3.68761   5.49097   1.000 24.62539  ? 54  GLY A HA3  1 
ATOM   902  N N    . GLN A 1 60  ? 26.67324 4.34429   7.79734   1.000 14.42175  ? 55  GLN A N    1 
ATOM   903  C CA   . GLN A 1 60  ? 27.45714 4.07896   8.98077   1.000 15.37556  ? 55  GLN A CA   1 
ATOM   904  C C    . GLN A 1 60  ? 26.65725 4.31932   10.26778  1.000 32.93744  ? 55  GLN A C    1 
ATOM   905  O O    . GLN A 1 60  ? 26.77460 3.55693   11.25213  1.000 11.51654  ? 55  GLN A O    1 
ATOM   906  C CB   . GLN A 1 60  ? 28.71550 4.94835   8.93288   1.000 20.69818  ? 55  GLN A CB   1 
ATOM   907  C CG   . GLN A 1 60  ? 29.55788 4.71619   7.67896   1.000 26.09318  ? 55  GLN A CG   1 
ATOM   908  C CD   . GLN A 1 60  ? 30.75184 5.64903   7.56192   1.000 24.16761  ? 55  GLN A CD   1 
ATOM   909  O OE1  . GLN A 1 60  ? 30.63341 6.87387   7.74811   1.000 21.30790  ? 55  GLN A OE1  1 
ATOM   910  N NE2  . GLN A 1 60  ? 31.91509 5.07827   7.23665   1.000 31.38378  ? 55  GLN A NE2  1 
ATOM   911  H H    . GLN A 1 60  ? 26.97017 4.99474   7.31949   1.000 17.32850  ? 55  GLN A H    1 
ATOM   912  H HA   . GLN A 1 60  ? 27.72107 3.14566   8.99497   1.000 18.47307  ? 55  GLN A HA   1 
ATOM   913  H HB2  . GLN A 1 60  ? 28.45314 5.88207   8.94801   1.000 24.86022  ? 55  GLN A HB2  1 
ATOM   914  H HB3  . GLN A 1 60  ? 29.26678 4.74608   9.70494   1.000 24.86022  ? 55  GLN A HB3  1 
ATOM   915  H HG2  . GLN A 1 60  ? 29.89379 3.80632   7.69254   1.000 31.33421  ? 55  GLN A HG2  1 
ATOM   916  H HG3  . GLN A 1 60  ? 28.99900 4.85188   6.89784   1.000 31.33421  ? 55  GLN A HG3  1 
ATOM   917  H HE21 . GLN A 1 60  ? 31.95598 4.22910   7.10684   1.000 37.68294  ? 55  GLN A HE21 1 
ATOM   918  H HE22 . GLN A 1 60  ? 32.62304 5.56001   7.15706   1.000 37.68294  ? 55  GLN A HE22 1 
ATOM   919  N N    . ARG A 1 61  ? 25.86667 5.38245   10.29441  1.000 17.23388  ? 56  ARG A N    1 
ATOM   920  C CA   . ARG A 1 61  ? 25.08977 5.68237   11.48485  1.000 14.57985  ? 56  ARG A CA   1 
ATOM   921  C C    . ARG A 1 61  ? 24.10583 4.56337   11.76216  1.000 13.90476  ? 56  ARG A C    1 
ATOM   922  O O    . ARG A 1 61  ? 23.91220 4.15284   12.91913  1.000 17.86439  ? 56  ARG A O    1 
ATOM   923  C CB   . ARG A 1 61  ? 24.31497 7.00285   11.32005  1.000 12.40631  ? 56  ARG A CB   1 
ATOM   924  C CG   . ARG A 1 61  ? 25.11194 8.29766   11.41339  1.000 12.16414  ? 56  ARG A CG   1 
ATOM   925  C CD   . ARG A 1 61  ? 24.28117 9.53893   10.88109  1.000 18.23924  ? 56  ARG A CD   1 
ATOM   926  N NE   . ARG A 1 61  ? 23.49929 10.25367  11.89514  1.000 14.51025  ? 56  ARG A NE   1 
ATOM   927  C CZ   . ARG A 1 61  ? 22.43312 11.01868  11.64829  1.000 26.61694  ? 56  ARG A CZ   1 
ATOM   928  N NH1  . ARG A 1 61  ? 21.90654 11.09825  10.44611  1.000 10.29194  ? 56  ARG A NH1  1 
ATOM   929  N NH2  . ARG A 1 61  ? 21.87243 11.71396  12.64341  1.000 15.23713  ? 56  ARG A NH2  1 
ATOM   930  H H    . ARG A 1 61  ? 25.76343 5.93816   9.64624   1.000 20.70305  ? 56  ARG A H    1 
ATOM   931  H HA   . ARG A 1 61  ? 25.70088 5.78248   12.23146  1.000 17.51823  ? 56  ARG A HA   1 
ATOM   932  H HB2  . ARG A 1 61  ? 23.89452 6.99438   10.44596  1.000 14.90997  ? 56  ARG A HB2  1 
ATOM   933  H HB3  . ARG A 1 61  ? 23.63780 7.03939   12.01359  1.000 14.90997  ? 56  ARG A HB3  1 
ATOM   934  H HG2  . ARG A 1 61  ? 25.34600 8.46364   12.33998  1.000 14.61937  ? 56  ARG A HG2  1 
ATOM   935  H HG3  . ARG A 1 61  ? 25.91632 8.21805   10.87717  1.000 14.61937  ? 56  ARG A HG3  1 
ATOM   936  H HD2  . ARG A 1 61  ? 24.89946 10.17659  10.49120  1.000 21.90949  ? 56  ARG A HD2  1 
ATOM   937  H HD3  . ARG A 1 61  ? 23.65945 9.22445   10.20621  1.000 21.90949  ? 56  ARG A HD3  1 
ATOM   938  H HE   . ARG A 1 61  ? 23.74739 10.17368  12.71468  1.000 17.43470  ? 56  ARG A HE   1 
ATOM   939  H HH11 . ARG A 1 61  ? 22.24903 10.65114  9.79620   1.000 12.37273  ? 56  ARG A HH11 1 
ATOM   940  H HH12 . ARG A 1 61  ? 21.21962 11.59739  10.30973  1.000 12.37273  ? 56  ARG A HH12 1 
ATOM   941  H HH21 . ARG A 1 61  ? 22.19864 11.66709  13.43776  1.000 18.30695  ? 56  ARG A HH21 1 
ATOM   942  H HH22 . ARG A 1 61  ? 21.18562 12.20799  12.48907  1.000 18.30695  ? 56  ARG A HH22 1 
ATOM   943  N N    . ALA A 1 62  ? 23.44339 4.07656   10.71235  1.000 25.84692  ? 57  ALA A N    1 
ATOM   944  C CA   . ALA A 1 62  ? 22.42051 3.06592   10.91346  1.000 15.99105  ? 57  ALA A CA   1 
ATOM   945  C C    . ALA A 1 62  ? 23.02900 1.74993   11.37034  1.000 18.87818  ? 57  ALA A C    1 
ATOM   946  O O    . ALA A 1 62  ? 22.42064 1.01857   12.16003  1.000 22.29369  ? 57  ALA A O    1 
ATOM   947  C CB   . ALA A 1 62  ? 21.61809 2.87163   9.63977   1.000 17.71192  ? 57  ALA A CB   1 
ATOM   948  H H    . ALA A 1 62  ? 23.56748 4.31190   9.89454   1.000 31.03870  ? 57  ALA A H    1 
ATOM   949  H HA   . ALA A 1 62  ? 21.80744 3.36855   11.60155  1.000 19.21167  ? 57  ALA A HA   1 
ATOM   950  H HB1  . ALA A 1 62  ? 21.07814 2.07042   9.72582   1.000 21.27671  ? 57  ALA A HB1  1 
ATOM   951  H HB2  . ALA A 1 62  ? 21.04586 3.64339   9.50621   1.000 21.27671  ? 57  ALA A HB2  1 
ATOM   952  H HB3  . ALA A 1 62  ? 22.22944 2.77982   8.89229   1.000 21.27671  ? 57  ALA A HB3  1 
ATOM   953  N N    . ALA A 1 63  ? 24.22297 1.42566   10.89131  1.000 28.59175  ? 58  ALA A N    1 
ATOM   954  C CA   . ALA A 1 63  ? 24.80621 0.15194   11.28462  1.000 19.05168  ? 58  ALA A CA   1 
ATOM   955  C C    . ALA A 1 63  ? 25.39157 0.23435   12.68521  1.000 25.37318  ? 58  ALA A C    1 
ATOM   956  O O    . ALA A 1 63  ? 25.26758 -0.72179  13.45487  1.000 16.48630  ? 58  ALA A O    1 
ATOM   957  C CB   . ALA A 1 63  ? 25.85222 -0.27148  10.26626  1.000 5.27375   ? 58  ALA A CB   1 
ATOM   958  H H    . ALA A 1 63  ? 24.69719 1.90604   10.35843  1.000 34.33250  ? 58  ALA A H    1 
ATOM   959  H HA   . ALA A 1 63  ? 24.12130 -0.53490  11.29307  1.000 22.88441  ? 58  ALA A HA   1 
ATOM   960  H HB1  . ALA A 1 63  ? 25.41304 -0.46003  9.42218   1.000 6.35090   ? 58  ALA A HB1  1 
ATOM   961  H HB2  . ALA A 1 63  ? 26.49201 0.44869   10.15262  1.000 6.35090   ? 58  ALA A HB2  1 
ATOM   962  H HB3  . ALA A 1 63  ? 26.30356 -1.06701  10.58925  1.000 6.35090   ? 58  ALA A HB3  1 
ATOM   963  N N    . TRP A 1 64  ? 26.01375 1.37623   13.03112  1.000 22.46029  ? 59  TRP A N    1 
ATOM   964  C CA   . TRP A 1 64  ? 26.43276 1.63763   14.40737  1.000 15.06895  ? 59  TRP A CA   1 
ATOM   965  C C    . TRP A 1 64  ? 25.28430 1.52072   15.41910  1.000 24.28323  ? 59  TRP A C    1 
ATOM   966  O O    . TRP A 1 64  ? 25.49302 1.08616   16.55381  1.000 20.11358  ? 59  TRP A O    1 
ATOM   967  C CB   . TRP A 1 64  ? 27.06987 3.03149   14.50910  1.000 17.29063  ? 59  TRP A CB   1 
ATOM   968  C CG   . TRP A 1 64  ? 27.67840 3.38705   15.91628  1.000 19.57675  ? 59  TRP A CG   1 
ATOM   969  C CD1  . TRP A 1 64  ? 28.99192 3.26549   16.30800  1.000 27.51935  ? 59  TRP A CD1  1 
ATOM   970  C CD2  . TRP A 1 64  ? 26.98634 3.92231   17.05035  1.000 24.02220  ? 59  TRP A CD2  1 
ATOM   971  N NE1  . TRP A 1 64  ? 29.16709 3.70975   17.61342  1.000 9.28771   ? 59  TRP A NE1  1 
ATOM   972  C CE2  . TRP A 1 64  ? 27.94533 4.09981   18.09281  1.000 29.25833  ? 59  TRP A CE2  1 
ATOM   973  C CE3  . TRP A 1 64  ? 25.65765 4.27310   17.29479  1.000 18.38500  ? 59  TRP A CE3  1 
ATOM   974  C CZ2  . TRP A 1 64  ? 27.60685 4.60489   19.34279  1.000 23.31304  ? 59  TRP A CZ2  1 
ATOM   975  C CZ3  . TRP A 1 64  ? 25.32779 4.75494   18.55524  1.000 34.27891  ? 59  TRP A CZ3  1 
ATOM   976  C CH2  . TRP A 1 64  ? 26.30356 4.91111   19.56418  1.000 18.54537  ? 59  TRP A CH2  1 
ATOM   977  H H    . TRP A 1 64  ? 26.20241 2.01212   12.48371  1.000 26.97475  ? 59  TRP A H    1 
ATOM   978  H HA   . TRP A 1 64  ? 27.09626 0.97036   14.64278  1.000 18.10514  ? 59  TRP A HA   1 
ATOM   979  H HB2  . TRP A 1 64  ? 27.78809 3.08848   13.85964  1.000 20.77116  ? 59  TRP A HB2  1 
ATOM   980  H HB3  . TRP A 1 64  ? 26.39011 3.69452   14.31106  1.000 20.77116  ? 59  TRP A HB3  1 
ATOM   981  H HD1  . TRP A 1 64  ? 29.67266 2.93031   15.77027  1.000 33.04562  ? 59  TRP A HD1  1 
ATOM   982  H HE1  . TRP A 1 64  ? 29.91121 3.73512   18.04381  1.000 11.16766  ? 59  TRP A HE1  1 
ATOM   983  H HE3  . TRP A 1 64  ? 25.01098 4.18663   16.63204  1.000 22.08441  ? 59  TRP A HE3  1 
ATOM   984  H HZ2  . TRP A 1 64  ? 28.24997 4.72840   20.00312  1.000 27.99805  ? 59  TRP A HZ2  1 
ATOM   985  H HZ3  . TRP A 1 64  ? 24.44426 4.97979   18.73886  1.000 41.15709  ? 59  TRP A HZ3  1 
ATOM   986  H HH2  . TRP A 1 64  ? 26.04718 5.23098   20.39896  1.000 22.27685  ? 59  TRP A HH2  1 
ATOM   987  N N    . ARG A 1 65  ? 24.07187 1.87614   15.03450  1.000 22.19825  ? 60  ARG A N    1 
ATOM   988  C CA   . ARG A 1 65  ? 22.97334 1.78683   15.98902  1.000 24.29819  ? 60  ARG A CA   1 
ATOM   989  C C    . ARG A 1 65  ? 22.54056 0.34515   16.23446  1.000 24.60486  ? 60  ARG A C    1 
ATOM   990  O O    . ARG A 1 65  ? 22.18615 -0.02651  17.36322  1.000 26.35572  ? 60  ARG A O    1 
ATOM   991  C CB   . ARG A 1 65  ? 21.79031 2.60551   15.48843  1.000 35.84620  ? 60  ARG A CB   1 
ATOM   992  C CG   . ARG A 1 65  ? 22.03079 4.11520   15.52637  1.000 33.16965  ? 60  ARG A CG   1 
ATOM   993  C CD   . ARG A 1 65  ? 20.94648 4.81291   14.72777  1.000 31.97150  ? 60  ARG A CD   1 
ATOM   994  N NE   . ARG A 1 65  ? 21.26681 6.20648   14.47368  1.000 34.83768  ? 60  ARG A NE   1 
ATOM   995  C CZ   . ARG A 1 65  ? 20.59123 6.96904   13.63021  1.000 35.25322  ? 60  ARG A CZ   1 
ATOM   996  N NH1  . ARG A 1 65  ? 19.60269 6.47514   12.90055  1.000 26.79805  ? 60  ARG A NH1  1 
ATOM   997  N NH2  . ARG A 1 65  ? 20.91073 8.25797   13.52268  1.000 38.37202  ? 60  ARG A NH2  1 
ATOM   998  H H    . ARG A 1 65  ? 23.86004 2.16397   14.25227  1.000 26.66030  ? 60  ARG A H    1 
ATOM   999  H HA   . ARG A 1 65  ? 23.27678 2.15251   16.83466  1.000 29.18023  ? 60  ARG A HA   1 
ATOM   1000 H HB2  . ARG A 1 65  ? 21.60537 2.35742   14.56911  1.000 43.03784  ? 60  ARG A HB2  1 
ATOM   1001 H HB3  . ARG A 1 65  ? 21.01962 2.41362   16.04531  1.000 43.03784  ? 60  ARG A HB3  1 
ATOM   1002 H HG2  . ARG A 1 65  ? 21.99930 4.43151   16.44281  1.000 39.82598  ? 60  ARG A HG2  1 
ATOM   1003 H HG3  . ARG A 1 65  ? 22.89319 4.32203   15.13346  1.000 39.82598  ? 60  ARG A HG3  1 
ATOM   1004 H HD2  . ARG A 1 65  ? 20.84199 4.36575   13.87335  1.000 38.38821  ? 60  ARG A HD2  1 
ATOM   1005 H HD3  . ARG A 1 65  ? 20.11357 4.77942   15.22379  1.000 38.38821  ? 60  ARG A HD3  1 
ATOM   1006 H HE   . ARG A 1 65  ? 21.93138 6.55451   14.89419  1.000 41.82761  ? 60  ARG A HE   1 
ATOM   1007 H HH11 . ARG A 1 65  ? 19.38993 5.64481   12.97046  1.000 32.18006  ? 60  ARG A HH11 1 
ATOM   1008 H HH12 . ARG A 1 65  ? 19.17344 6.98471   12.35678  1.000 32.18006  ? 60  ARG A HH12 1 
ATOM   1009 H HH21 . ARG A 1 65  ? 21.54888 8.58392   13.99820  1.000 46.06883  ? 60  ARG A HH21 1 
ATOM   1010 H HH22 . ARG A 1 65  ? 20.47882 8.76404   12.97774  1.000 46.06883  ? 60  ARG A HH22 1 
ATOM   1011 N N    . VAL A 1 66  ? 22.49311 -0.46354  15.18316  1.000 23.24845  ? 61  VAL A N    1 
ATOM   1012 C CA   . VAL A 1 66  ? 22.19701 -1.88158  15.36421  1.000 24.06833  ? 61  VAL A CA   1 
ATOM   1013 C C    . VAL A 1 66  ? 23.19479 -2.49271  16.33316  1.000 29.76607  ? 61  VAL A C    1 
ATOM   1014 O O    . VAL A 1 66  ? 22.82645 -3.02873  17.38479  1.000 22.76214  ? 61  VAL A O    1 
ATOM   1015 C CB   . VAL A 1 66  ? 22.22013 -2.59908  14.00751  1.000 21.88956  ? 61  VAL A CB   1 
ATOM   1016 C CG1  . VAL A 1 66  ? 22.53654 -4.09599  14.15105  1.000 4.95181   ? 61  VAL A CG1  1 
ATOM   1017 C CG2  . VAL A 1 66  ? 20.91323 -2.33371  13.29553  1.000 25.20429  ? 61  VAL A CG2  1 
ATOM   1018 H H    . VAL A 1 66  ? 22.62585 -0.22269  14.36831  1.000 27.92055  ? 61  VAL A H    1 
ATOM   1019 H HA   . VAL A 1 66  ? 21.30939 -1.97916  15.74303  1.000 28.90440  ? 61  VAL A HA   1 
ATOM   1020 H HB   . VAL A 1 66  ? 22.94011 -2.24868  13.46001  1.000 26.28987  ? 61  VAL A HB   1 
ATOM   1021 H HG11 . VAL A 1 66  ? 23.49842 -4.21246  14.19707  1.000 5.96458   ? 61  VAL A HG11 1 
ATOM   1022 H HG12 . VAL A 1 66  ? 22.12373 -4.42959  14.96296  1.000 5.96458   ? 61  VAL A HG12 1 
ATOM   1023 H HG13 . VAL A 1 66  ? 22.18253 -4.56880  13.38161  1.000 5.96458   ? 61  VAL A HG13 1 
ATOM   1024 H HG21 . VAL A 1 66  ? 20.99384 -2.61715  12.37138  1.000 30.26754  ? 61  VAL A HG21 1 
ATOM   1025 H HG22 . VAL A 1 66  ? 20.20730 -2.83361  13.73446  1.000 30.26754  ? 61  VAL A HG22 1 
ATOM   1026 H HG23 . VAL A 1 66  ? 20.71951 -1.38405  13.33455  1.000 30.26754  ? 61  VAL A HG23 1 
ATOM   1027 N N    . LEU A 1 67  ? 24.48122 -2.34598  16.01396  1.000 19.96935  ? 62  LEU A N    1 
ATOM   1028 C CA   . LEU A 1 67  ? 25.53510 -2.97244  16.79671  1.000 23.18326  ? 62  LEU A CA   1 
ATOM   1029 C C    . LEU A 1 67  ? 25.48346 -2.54180  18.25674  1.000 26.90466  ? 62  LEU A C    1 
ATOM   1030 O O    . LEU A 1 67  ? 25.59108 -3.37709  19.15847  1.000 32.91068  ? 62  LEU A O    1 
ATOM   1031 C CB   . LEU A 1 67  ? 26.89642 -2.65043  16.17274  1.000 10.75005  ? 62  LEU A CB   1 
ATOM   1032 C CG   . LEU A 1 67  ? 27.19957 -3.21552  14.77554  1.000 11.94421  ? 62  LEU A CG   1 
ATOM   1033 C CD1  . LEU A 1 67  ? 28.59682 -2.86581  14.29721  1.000 13.99851  ? 62  LEU A CD1  1 
ATOM   1034 C CD2  . LEU A 1 67  ? 27.04615 -4.70184  14.74722  1.000 24.18974  ? 62  LEU A CD2  1 
ATOM   1035 H H    . LEU A 1 67  ? 24.76808 -1.88653  15.34597  1.000 23.98563  ? 62  LEU A H    1 
ATOM   1036 H HA   . LEU A 1 67  ? 25.41119 -3.93430  16.77780  1.000 27.84232  ? 62  LEU A HA   1 
ATOM   1037 H HB2  . LEU A 1 67  ? 26.96888 -1.68552  16.10505  1.000 12.92246  ? 62  LEU A HB2  1 
ATOM   1038 H HB3  . LEU A 1 67  ? 27.58179 -2.99372  16.76714  1.000 12.92246  ? 62  LEU A HB3  1 
ATOM   1039 H HG   . LEU A 1 67  ? 26.55909 -2.80896  14.17107  1.000 14.35546  ? 62  LEU A HG   1 
ATOM   1040 H HD11 . LEU A 1 67  ? 28.73460 -1.91073  14.39595  1.000 16.82062  ? 62  LEU A HD11 1 
ATOM   1041 H HD12 . LEU A 1 67  ? 29.24442 -3.35052  14.83253  1.000 16.82062  ? 62  LEU A HD12 1 
ATOM   1042 H HD13 . LEU A 1 67  ? 28.68365 -3.11786  13.36457  1.000 16.82062  ? 62  LEU A HD13 1 
ATOM   1043 H HD21 . LEU A 1 67  ? 27.42249 -5.04247  13.92064  1.000 29.05009  ? 62  LEU A HD21 1 
ATOM   1044 H HD22 . LEU A 1 67  ? 27.51569 -5.08230  15.50596  1.000 29.05009  ? 62  LEU A HD22 1 
ATOM   1045 H HD23 . LEU A 1 67  ? 26.10301 -4.92297  14.79711  1.000 29.05009  ? 62  LEU A HD23 1 
ATOM   1046 N N    . SER A 1 68  ? 25.32743 -1.23342  18.51471  1.000 33.77624  ? 63  SER A N    1 
ATOM   1047 C CA   . SER A 1 68  ? 25.41012 -0.71858  19.88467  1.000 22.96808  ? 63  SER A CA   1 
ATOM   1048 C C    . SER A 1 68  ? 24.26843 -1.23526  20.75824  1.000 31.79695  ? 63  SER A C    1 
ATOM   1049 O O    . SER A 1 68  ? 24.42208 -1.33517  21.98442  1.000 17.07305  ? 63  SER A O    1 
ATOM   1050 C CB   . SER A 1 68  ? 25.41739 0.81895   19.87365  1.000 24.71796  ? 63  SER A CB   1 
ATOM   1051 O OG   . SER A 1 68  ? 25.24325 1.33153   21.17801  1.000 40.60505  ? 63  SER A OG   1 
ATOM   1052 H H    . SER A 1 68  ? 25.17460 -0.63170  17.91959  1.000 40.55389  ? 63  SER A H    1 
ATOM   1053 H HA   . SER A 1 68  ? 26.24447 -1.02107  20.27616  1.000 27.58410  ? 63  SER A HA   1 
ATOM   1054 H HB2  . SER A 1 68  ? 26.26757 1.12821   19.52372  1.000 29.68396  ? 63  SER A HB2  1 
ATOM   1055 H HB3  . SER A 1 68  ? 24.69270 1.13413   19.31115  1.000 29.68396  ? 63  SER A HB3  1 
ATOM   1056 H HG   . SER A 1 68  ? 25.88565 1.09839   21.66644  1.000 48.74846  ? 63  SER A HG   1 
ATOM   1057 N N    . SER A 1 69  ? 23.14122 -1.59605  20.13900  1.000 31.40007  ? 64  SER A N    1 
ATOM   1058 C CA   . SER A 1 69  ? 21.97868 -2.12995  20.84645  1.000 16.13474  ? 64  SER A CA   1 
ATOM   1059 C C    . SER A 1 69  ? 22.17510 -3.58584  21.24807  1.000 24.71179  ? 64  SER A C    1 
ATOM   1060 O O    . SER A 1 69  ? 21.75450 -4.00413  22.33694  1.000 32.97723  ? 64  SER A O    1 
ATOM   1061 C CB   . SER A 1 69  ? 20.74781 -1.99526  19.94899  1.000 40.47761  ? 64  SER A CB   1 
ATOM   1062 O OG   . SER A 1 69  ? 19.61188 -2.59698  20.53216  1.000 44.86652  ? 64  SER A OG   1 
ATOM   1063 H H    . SER A 1 69  ? 23.02187 -1.53998  19.28917  1.000 37.70249  ? 64  SER A H    1 
ATOM   1064 H HA   . SER A 1 69  ? 21.83888 -1.61875  21.65887  1.000 19.38409  ? 64  SER A HA   1 
ATOM   1065 H HB2  . SER A 1 69  ? 20.56508 -1.05313  19.80796  1.000 48.59553  ? 64  SER A HB2  1 
ATOM   1066 H HB3  . SER A 1 69  ? 20.93040 -2.42843  19.10051  1.000 48.59553  ? 64  SER A HB3  1 
ATOM   1067 H HG   . SER A 1 69  ? 18.94721 -2.50611  20.02664  1.000 53.86223  ? 64  SER A HG   1 
ATOM   1068 N N    . ILE A 1 70  ? 22.78607 -4.37796  20.36570  1.000 29.60199  ? 65  ILE A N    1 
ATOM   1069 C CA   . ILE A 1 70  ? 23.16778 -5.74379  20.72629  1.000 18.65470  ? 65  ILE A CA   1 
ATOM   1070 C C    . ILE A 1 70  ? 24.15650 -5.70221  21.88490  1.000 24.03456  ? 65  ILE A C    1 
ATOM   1071 O O    . ILE A 1 70  ? 24.00802 -6.42730  22.87364  1.000 27.85396  ? 65  ILE A O    1 
ATOM   1072 C CB   . ILE A 1 70  ? 23.73034 -6.46028  19.47996  1.000 24.76113  ? 65  ILE A CB   1 
ATOM   1073 C CG1  . ILE A 1 70  ? 22.65880 -6.54853  18.37949  1.000 9.96391   ? 65  ILE A CG1  1 
ATOM   1074 C CG2  . ILE A 1 70  ? 24.23412 -7.85305  19.80142  1.000 21.31049  ? 65  ILE A CG2  1 
ATOM   1075 C CD1  . ILE A 1 70  ? 23.21450 -6.90076  17.00363  1.000 23.91039  ? 65  ILE A CD1  1 
ATOM   1076 H H    . ILE A 1 70  ? 22.98889 -4.15212  19.56105  1.000 35.54479  ? 65  ILE A H    1 
ATOM   1077 H HA   . ILE A 1 70  ? 22.39306 -6.24555  21.02450  1.000 22.40804  ? 65  ILE A HA   1 
ATOM   1078 H HB   . ILE A 1 70  ? 24.48017 -5.92982  19.16809  1.000 29.73576  ? 65  ILE A HB   1 
ATOM   1079 H HG12 . ILE A 1 70  ? 22.01747 -7.23411  18.62356  1.000 11.97909  ? 65  ILE A HG12 1 
ATOM   1080 H HG13 . ILE A 1 70  ? 22.21463 -5.68919  18.30769  1.000 11.97909  ? 65  ILE A HG13 1 
ATOM   1081 H HG21 . ILE A 1 70  ? 23.50136 -8.37957  20.15744  1.000 25.59498  ? 65  ILE A HG21 1 
ATOM   1082 H HG22 . ILE A 1 70  ? 24.57134 -8.26220  18.98916  1.000 25.59498  ? 65  ILE A HG22 1 
ATOM   1083 H HG23 . ILE A 1 70  ? 24.94458 -7.78802  20.45863  1.000 25.59498  ? 65  ILE A HG23 1 
ATOM   1084 H HD11 . ILE A 1 70  ? 22.49987 -6.84332  16.35024  1.000 28.71487  ? 65  ILE A HD11 1 
ATOM   1085 H HD12 . ILE A 1 70  ? 23.91998 -6.27437  16.77816  1.000 28.71487  ? 65  ILE A HD12 1 
ATOM   1086 H HD13 . ILE A 1 70  ? 23.56885 -7.80339  17.02778  1.000 28.71487  ? 65  ILE A HD13 1 
ATOM   1087 N N    . GLU A 1 71  ? 25.13951 -4.80553  21.81334  1.000 24.10426  ? 66  GLU A N    1 
ATOM   1088 C CA   . GLU A 1 71  ? 26.14205 -4.71237  22.86367  1.000 17.74087  ? 66  GLU A CA   1 
ATOM   1089 C C    . GLU A 1 71  ? 25.47480 -4.43158  24.20190  1.000 43.38448  ? 66  GLU A C    1 
ATOM   1090 O O    . GLU A 1 71  ? 25.82527 -5.05102  25.21038  1.000 25.42701  ? 66  GLU A O    1 
ATOM   1091 C CB   . GLU A 1 71  ? 27.17190 -3.62744  22.52200  1.000 19.43269  ? 66  GLU A CB   1 
ATOM   1092 C CG   . GLU A 1 71  ? 28.28978 -3.45189  23.57814  1.000 25.83027  ? 66  GLU A CG   1 
ATOM   1093 C CD   . GLU A 1 71  ? 29.36971 -2.47286  23.14987  1.000 39.90926  ? 66  GLU A CD   1 
ATOM   1094 O OE1  . GLU A 1 71  ? 29.03448 -1.59811  22.33943  1.000 23.44445  ? 66  GLU A OE1  1 
ATOM   1095 O OE2  . GLU A 1 71  ? 30.54547 -2.57341  23.60313  1.000 30.75376  ? 66  GLU A OE2  1 
ATOM   1096 H H    . GLU A 1 71  ? 25.24580 -4.24422  21.17051  1.000 28.94751  ? 66  GLU A H    1 
ATOM   1097 H HA   . GLU A 1 71  ? 26.62261 -5.55240  22.92924  1.000 21.31145  ? 66  GLU A HA   1 
ATOM   1098 H HB2  . GLU A 1 71  ? 27.59648 -3.85788  21.68086  1.000 23.34162  ? 66  GLU A HB2  1 
ATOM   1099 H HB3  . GLU A 1 71  ? 26.71059 -2.77819  22.43907  1.000 23.34162  ? 66  GLU A HB3  1 
ATOM   1100 H HG2  . GLU A 1 71  ? 27.89615 -3.12045  24.40040  1.000 31.01873  ? 66  GLU A HG2  1 
ATOM   1101 H HG3  . GLU A 1 71  ? 28.71171 -4.31110  23.73509  1.000 31.01873  ? 66  GLU A HG3  1 
ATOM   1102 N N    . GLN A 1 72  ? 24.48125 -3.52591  24.22501  1.000 45.63264  ? 67  GLN A N    1 
ATOM   1103 C CA   . GLN A 1 72  ? 23.78877 -3.17932  25.46218  1.000 37.79265  ? 67  GLN A CA   1 
ATOM   1104 C C    . GLN A 1 72  ? 22.80045 -4.26397  25.90232  1.000 48.41794  ? 67  GLN A C    1 
ATOM   1105 O O    . GLN A 1 72  ? 22.60415 -4.45691  27.10593  1.000 56.15096  ? 67  GLN A O    1 
ATOM   1106 C CB   . GLN A 1 72  ? 23.03977 -1.84893  25.30784  1.000 58.42596  ? 67  GLN A CB   1 
ATOM   1107 C CG   . GLN A 1 72  ? 23.89709 -0.54275  25.29132  1.000 65.21329  ? 67  GLN A CG   1 
ATOM   1108 C CD   . GLN A 1 72  ? 25.05268 -0.51768  26.29334  1.000 76.09484  ? 67  GLN A CD   1 
ATOM   1109 O OE1  . GLN A 1 72  ? 24.85320 -0.49478  27.52427  1.000 69.02055  ? 67  GLN A OE1  1 
ATOM   1110 N NE2  . GLN A 1 72  ? 26.27630 -0.49166  25.76156  1.000 53.84393  ? 67  GLN A NE2  1 
ATOM   1111 H H    . GLN A 1 72  ? 24.19412 -3.10160  23.53426  1.000 54.78157  ? 67  GLN A H    1 
ATOM   1112 H HA   . GLN A 1 72  ? 24.45826 -3.07406  26.15616  1.000 45.37359  ? 67  GLN A HA   1 
ATOM   1113 H HB2  . GLN A 1 72  ? 22.55314 -1.87633  24.46919  1.000 70.13355  ? 67  GLN A HB2  1 
ATOM   1114 H HB3  . GLN A 1 72  ? 22.41921 -1.76845  26.04901  1.000 70.13355  ? 67  GLN A HB3  1 
ATOM   1115 H HG2  . GLN A 1 72  ? 24.27791 -0.43576  24.40564  1.000 78.27835  ? 67  GLN A HG2  1 
ATOM   1116 H HG3  . GLN A 1 72  ? 23.31813 0.20800   25.49642  1.000 78.27835  ? 67  GLN A HG3  1 
ATOM   1117 H HE21 . GLN A 1 72  ? 26.37386 -0.48986  24.90711  1.000 64.63511  ? 67  GLN A HE21 1 
ATOM   1118 H HE22 . GLN A 1 72  ? 26.96732 -0.47670  26.27329  1.000 64.63511  ? 67  GLN A HE22 1 
ATOM   1119 N N    . LYS A 1 73  ? 22.15054 -4.96697  24.96197  1.000 41.73189  ? 68  LYS A N    1 
ATOM   1120 C CA   . LYS A 1 73  ? 21.31887 -6.10098  25.35532  1.000 37.08660  ? 68  LYS A CA   1 
ATOM   1121 C C    . LYS A 1 73  ? 22.14838 -7.16662  26.05661  1.000 51.74918  ? 68  LYS A C    1 
ATOM   1122 O O    . LYS A 1 73  ? 21.64979 -7.85181  26.95419  1.000 65.29030  ? 68  LYS A O    1 
ATOM   1123 C CB   . LYS A 1 73  ? 20.61730 -6.72396  24.15348  1.000 34.60411  ? 68  LYS A CB   1 
ATOM   1124 H H    . LYS A 1 73  ? 22.17668 -4.80909  24.11699  1.000 50.10067  ? 68  LYS A H    1 
ATOM   1125 H HA   . LYS A 1 73  ? 20.63308 -5.77087  25.95666  1.000 44.52632  ? 68  LYS A HA   1 
ATOM   1126 N N    . SER A 1 74  ? 23.41578 -7.31080  25.67027  1.000 37.54675  ? 69  SER A N    1 
ATOM   1127 C CA   . SER A 1 74  ? 24.34313 -8.21378  26.33286  1.000 60.81816  ? 69  SER A CA   1 
ATOM   1128 C C    . SER A 1 74  ? 24.85179 -7.67247  27.66418  1.000 52.40236  ? 69  SER A C    1 
ATOM   1129 O O    . SER A 1 74  ? 25.92345 -8.08669  28.11185  1.000 59.19958  ? 69  SER A O    1 
ATOM   1130 C CB   . SER A 1 74  ? 25.52476 -8.51822  25.40884  1.000 47.22950  ? 69  SER A CB   1 
ATOM   1131 O OG   . SER A 1 74  ? 25.09211 -9.30318  24.31116  1.000 57.32946  ? 69  SER A OG   1 
ATOM   1132 H H    . SER A 1 74  ? 23.76610 -6.88431  25.01073  1.000 45.07850  ? 69  SER A H    1 
ATOM   1133 H HA   . SER A 1 74  ? 23.87986 -9.04676  26.51294  1.000 73.00419  ? 69  SER A HA   1 
ATOM   1134 H HB2  . SER A 1 74  ? 25.89480 -7.68453  25.07878  1.000 56.69780  ? 69  SER A HB2  1 
ATOM   1135 H HB3  . SER A 1 74  ? 26.19977 -9.00753  25.90466  1.000 56.69780  ? 69  SER A HB3  1 
ATOM   1136 H HG   . SER A 1 74  ? 25.71900 -9.39646  23.75988  1.000 68.81775  ? 69  SER A HG   1 
ATOM   1137 N N    . ASN A 1 75  ? 24.12383 -6.75416  28.28801  1.000 73.67685  ? 70  ASN A N    1 
ATOM   1138 C CA   . ASN A 1 75  ? 24.37063 -6.31710  29.66272  1.000 74.41500  ? 70  ASN A CA   1 
ATOM   1139 C C    . ASN A 1 75  ? 23.10002 -6.34790  30.50984  1.000 66.53331  ? 70  ASN A C    1 
ATOM   1140 O O    . ASN A 1 75  ? 23.14337 -6.78036  31.66286  1.000 54.95593  ? 70  ASN A O    1 
ATOM   1141 C CB   . ASN A 1 75  ? 24.98133 -4.89017  29.69818  1.000 71.01549  ? 70  ASN A CB   1 
ATOM   1142 C CG   . ASN A 1 75  ? 26.02689 -4.65339  28.59679  1.000 86.48750  ? 70  ASN A CG   1 
ATOM   1143 O OD1  . ASN A 1 75  ? 25.89091 -3.72619  27.79473  1.000 66.34627  ? 70  ASN A OD1  1 
ATOM   1144 N ND2  . ASN A 1 75  ? 27.07408 -5.48459  28.56256  1.000 65.79566  ? 70  ASN A ND2  1 
ATOM   1145 H H    . ASN A 1 75  ? 23.45548 -6.35236  27.92542  1.000 88.43462  ? 70  ASN A H    1 
ATOM   1146 H HA   . ASN A 1 75  ? 25.02324 -6.91486  30.05979  1.000 89.32040  ? 70  ASN A HA   1 
ATOM   1147 H HB2  . ASN A 1 75  ? 24.27068 -4.24071  29.57953  1.000 85.24099  ? 70  ASN A HB2  1 
ATOM   1148 H HB3  . ASN A 1 75  ? 25.41490 -4.75467  30.55525  1.000 85.24099  ? 70  ASN A HB3  1 
ATOM   1149 H HD21 . ASN A 1 75  ? 27.13991 -6.11737  29.14123  1.000 78.97720  ? 70  ASN A HD21 1 
ATOM   1150 H HD22 . ASN A 1 75  ? 27.68164 -5.38630  27.96188  1.000 78.97720  ? 70  ASN A HD22 1 
ATOM   1151 N N    . GLU A 1 76  ? 21.96570 -5.92004  29.96146  1.000 70.05414  ? 71  GLU A N    1 
ATOM   1152 C CA   . GLU A 1 76  ? 20.71100 -5.93641  30.70097  1.000 76.16898  ? 71  GLU A CA   1 
ATOM   1153 C C    . GLU A 1 76  ? 19.75347 -6.94574  30.06211  1.000 74.38471  ? 71  GLU A C    1 
ATOM   1154 O O    . GLU A 1 76  ? 20.12824 -8.09473  29.79820  1.000 52.77396  ? 71  GLU A O    1 
ATOM   1155 C CB   . GLU A 1 76  ? 20.09564 -4.53414  30.74118  1.000 59.73543  ? 71  GLU A CB   1 
ATOM   1156 H H    . GLU A 1 76  ? 21.89810 -5.61499  29.16022  1.000 84.08737  ? 71  GLU A H    1 
ATOM   1157 H HA   . GLU A 1 76  ? 20.86290 -6.20217  31.62141  1.000 91.42517  ? 71  GLU A HA   1 
ATOM   1158 N N    . GLU A 1 80  ? 24.25494 -15.87606 28.77066  1.000 106.82435 ? 75  GLU A N    1 
ATOM   1159 C CA   . GLU A 1 80  ? 25.67706 -15.78811 29.11232  1.000 106.55099 ? 75  GLU A CA   1 
ATOM   1160 C C    . GLU A 1 80  ? 26.32616 -14.72487 28.18504  1.000 92.05118  ? 75  GLU A C    1 
ATOM   1161 O O    . GLU A 1 80  ? 25.59798 -13.92939 27.58410  1.000 90.63694  ? 75  GLU A O    1 
ATOM   1162 C CB   . GLU A 1 80  ? 26.35265 -17.16735 29.00464  1.000 77.86674  ? 75  GLU A CB   1 
ATOM   1163 C CG   . GLU A 1 80  ? 25.56576 -18.41617 29.55842  1.000 70.90179  ? 75  GLU A CG   1 
ATOM   1164 C CD   . GLU A 1 80  ? 24.71811 -18.18925 30.83106  1.000 89.54647  ? 75  GLU A CD   1 
ATOM   1165 O OE1  . GLU A 1 80  ? 24.93811 -17.18533 31.53180  1.000 129.57205 ? 75  GLU A OE1  1 
ATOM   1166 O OE2  . GLU A 1 80  ? 23.83835 -19.03342 31.14823  1.000 87.04044  ? 75  GLU A OE2  1 
ATOM   1167 H H    . GLU A 1 80  ? 23.80331 -16.41019 29.26825  1.000 128.21162 ? 75  GLU A H    1 
ATOM   1168 H HA   . GLU A 1 80  ? 25.81144 -15.51620 30.03368  1.000 127.88359 ? 75  GLU A HA   1 
ATOM   1169 H HB2  . GLU A 1 80  ? 26.52482 -17.34021 28.06582  1.000 93.46249  ? 75  GLU A HB2  1 
ATOM   1170 H HB3  . GLU A 1 80  ? 27.18955 -17.12606 29.49329  1.000 93.46249  ? 75  GLU A HB3  1 
ATOM   1171 H HG2  . GLU A 1 80  ? 24.96043 -18.72273 28.86525  1.000 85.10455  ? 75  GLU A HG2  1 
ATOM   1172 H HG3  . GLU A 1 80  ? 26.21030 -19.11045 29.76687  1.000 85.10455  ? 75  GLU A HG3  1 
ATOM   1173 N N    . GLU A 1 81  ? 27.66612 -14.69823 28.07369  1.000 96.40005  ? 76  GLU A N    1 
ATOM   1174 C CA   . GLU A 1 81  ? 28.39156 -13.65539 27.34334  1.000 99.70684  ? 76  GLU A CA   1 
ATOM   1175 C C    . GLU A 1 81  ? 29.20045 -14.22125 26.18116  1.000 93.09556  ? 76  GLU A C    1 
ATOM   1176 O O    . GLU A 1 81  ? 30.05877 -15.08502 26.38812  1.000 81.61964  ? 76  GLU A O    1 
ATOM   1177 C CB   . GLU A 1 81  ? 29.36553 -12.89521 28.25474  1.000 107.56801 ? 76  GLU A CB   1 
ATOM   1178 C CG   . GLU A 1 81  ? 30.52396 -12.23150 27.48975  1.000 93.24003  ? 76  GLU A CG   1 
ATOM   1179 C CD   . GLU A 1 81  ? 31.08645 -11.01220 28.20406  1.000 103.86500 ? 76  GLU A CD   1 
ATOM   1180 O OE1  . GLU A 1 81  ? 31.25643 -11.07078 29.43940  1.000 110.13848 ? 76  GLU A OE1  1 
ATOM   1181 O OE2  . GLU A 1 81  ? 31.34640 -9.98919  27.53376  1.000 95.80200  ? 76  GLU A OE2  1 
ATOM   1182 H H    . GLU A 1 81  ? 28.18382 -15.28964 28.42271  1.000 115.70246 ? 76  GLU A H    1 
ATOM   1183 H HA   . GLU A 1 81  ? 27.71603 -13.05805 26.98593  1.000 119.67061 ? 76  GLU A HA   1 
ATOM   1184 H HB2  . GLU A 1 81  ? 28.87868 -12.19813 28.72160  1.000 129.10401 ? 76  GLU A HB2  1 
ATOM   1185 H HB3  . GLU A 1 81  ? 29.74785 -13.51743 28.89316  1.000 129.10401 ? 76  GLU A HB3  1 
ATOM   1186 H HG2  . GLU A 1 81  ? 31.24244 -12.87482 27.38565  1.000 111.91043 ? 76  GLU A HG2  1 
ATOM   1187 H HG3  . GLU A 1 81  ? 30.20466 -11.94700 26.61911  1.000 111.91043 ? 76  GLU A HG3  1 
ATOM   1188 N N    . LYS A 1 82  ? 29.00523 -13.64603 24.98281  1.000 103.20111 ? 77  LYS A N    1 
ATOM   1189 C CA   . LYS A 1 82  ? 29.52302 -14.18240 23.72167  1.000 94.32077  ? 77  LYS A CA   1 
ATOM   1190 C C    . LYS A 1 82  ? 31.01622 -13.93212 23.48556  1.000 89.82992  ? 77  LYS A C    1 
ATOM   1191 O O    . LYS A 1 82  ? 31.59666 -14.55595 22.58231  1.000 44.44524  ? 77  LYS A O    1 
ATOM   1192 C CB   . LYS A 1 82  ? 28.72063 -13.58535 22.55658  1.000 76.72309  ? 77  LYS A CB   1 
ATOM   1193 H H    . LYS A 1 82  ? 28.55977 -12.91851 24.87383  1.000 123.86373 ? 77  LYS A H    1 
ATOM   1194 H HA   . LYS A 1 82  ? 29.40576 -15.14519 23.73572  1.000 113.20732 ? 77  LYS A HA   1 
ATOM   1195 N N    . GLY A 1 83  ? 31.64907 -13.05137 24.26204  1.000 97.38223  ? 78  GLY A N    1 
ATOM   1196 C CA   . GLY A 1 83  ? 33.05310 -12.75076 24.10386  1.000 73.85986  ? 78  GLY A CA   1 
ATOM   1197 C C    . GLY A 1 83  ? 33.27439 -11.27518 23.83757  1.000 54.45203  ? 78  GLY A C    1 
ATOM   1198 O O    . GLY A 1 83  ? 32.38870 -10.44497 24.05341  1.000 40.33876  ? 78  GLY A O    1 
ATOM   1199 H H    . GLY A 1 83  ? 31.27165 -12.61121 24.89719  1.000 116.88108 ? 78  GLY A H    1 
ATOM   1200 H HA2  . GLY A 1 83  ? 33.53103 -12.99519 24.91177  1.000 88.65424  ? 78  GLY A HA2  1 
ATOM   1201 H HA3  . GLY A 1 83  ? 33.41227 -13.25762 23.35888  1.000 88.65424  ? 78  GLY A HA3  1 
ATOM   1202 N N    . PRO A 1 84  ? 34.47333 -10.92541 23.34565  1.000 32.29283  ? 79  PRO A N    1 
ATOM   1203 C CA   . PRO A 1 84  ? 34.76762 -9.53637  22.96075  1.000 50.53320  ? 79  PRO A CA   1 
ATOM   1204 C C    . PRO A 1 84  ? 34.30945 -9.14326  21.55776  1.000 36.98938  ? 79  PRO A C    1 
ATOM   1205 O O    . PRO A 1 84  ? 34.51707 -7.99273  21.15762  1.000 30.41903  ? 79  PRO A O    1 
ATOM   1206 C CB   . PRO A 1 84  ? 36.30446 -9.49430  23.05912  1.000 22.63705  ? 79  PRO A CB   1 
ATOM   1207 C CG   . PRO A 1 84  ? 36.72416 -10.81352 22.71859  1.000 35.16338  ? 79  PRO A CG   1 
ATOM   1208 C CD   . PRO A 1 84  ? 35.65470 -11.77706 23.19216  1.000 22.10056  ? 79  PRO A CD   1 
ATOM   1209 H HA   . PRO A 1 84  ? 34.37339 -8.92231  23.59982  1.000 60.66224  ? 79  PRO A HA   1 
ATOM   1210 H HB2  . PRO A 1 84  ? 36.65900 -8.84350  22.43329  1.000 27.18686  ? 79  PRO A HB2  1 
ATOM   1211 H HB3  . PRO A 1 84  ? 36.57266 -9.26581  23.96287  1.000 27.18686  ? 79  PRO A HB3  1 
ATOM   1212 H HG2  . PRO A 1 84  ? 36.83097 -10.87602 21.75652  1.000 42.21846  ? 79  PRO A HG2  1 
ATOM   1213 H HG3  . PRO A 1 84  ? 37.56718 -11.00384 23.15904  1.000 42.21846  ? 79  PRO A HG3  1 
ATOM   1214 H HD2  . PRO A 1 84  ? 35.49714 -12.46920 22.53110  1.000 26.54307  ? 79  PRO A HD2  1 
ATOM   1215 H HD3  . PRO A 1 84  ? 35.90296 -12.17815 24.03974  1.000 26.54307  ? 79  PRO A HD3  1 
ATOM   1216 N N    . GLU A 1 85  ? 33.66243 -10.04533 20.82624  1.000 40.65309  ? 80  GLU A N    1 
ATOM   1217 C CA   . GLU A 1 85  ? 33.47359 -9.86576  19.39428  1.000 33.83372  ? 80  GLU A CA   1 
ATOM   1218 C C    . GLU A 1 85  ? 32.54574 -8.69667  19.07324  1.000 36.65323  ? 80  GLU A C    1 
ATOM   1219 O O    . GLU A 1 85  ? 32.78273 -7.96893  18.10167  1.000 21.10272  ? 80  GLU A O    1 
ATOM   1220 C CB   . GLU A 1 85  ? 32.93183 -11.17343 18.80865  1.000 42.69002  ? 80  GLU A CB   1 
ATOM   1221 C CG   . GLU A 1 85  ? 33.99114 -12.26713 18.61927  1.000 21.82365  ? 80  GLU A CG   1 
ATOM   1222 C CD   . GLU A 1 85  ? 34.19863 -13.16999 19.83179  1.000 37.18216  ? 80  GLU A CD   1 
ATOM   1223 O OE1  . GLU A 1 85  ? 33.42569 -13.08375 20.81079  1.000 35.77603  ? 80  GLU A OE1  1 
ATOM   1224 O OE2  . GLU A 1 85  ? 35.15374 -13.98476 19.79129  1.000 36.73189  ? 80  GLU A OE2  1 
ATOM   1225 H H    . GLU A 1 85  ? 33.32232 -10.77190 21.13611  1.000 48.80611  ? 80  GLU A H    1 
ATOM   1226 H HA   . GLU A 1 85  ? 34.32714 -9.65996  18.98197  1.000 40.62287  ? 80  GLU A HA   1 
ATOM   1227 H HB2  . GLU A 1 85  ? 32.25263 -11.52262 19.40669  1.000 51.25042  ? 80  GLU A HB2  1 
ATOM   1228 H HB3  . GLU A 1 85  ? 32.54407 -10.98628 17.93945  1.000 51.25042  ? 80  GLU A HB3  1 
ATOM   1229 H HG2  . GLU A 1 85  ? 33.72266 -12.83177 17.87766  1.000 26.21078  ? 80  GLU A HG2  1 
ATOM   1230 H HG3  . GLU A 1 85  ? 34.84101 -11.84295 18.42257  1.000 26.21078  ? 80  GLU A HG3  1 
ATOM   1231 N N    . VAL A 1 86  ? 31.48182 -8.49894  19.86222  1.000 25.53173  ? 81  VAL A N    1 
ATOM   1232 C CA   . VAL A 1 86  ? 30.54972 -7.40628  19.57656  1.000 32.21368  ? 81  VAL A CA   1 
ATOM   1233 C C    . VAL A 1 86  ? 31.22671 -6.06440  19.80734  1.000 33.52993  ? 81  VAL A C    1 
ATOM   1234 O O    . VAL A 1 86  ? 31.09004 -5.15047  19.00098  1.000 18.15782  ? 81  VAL A O    1 
ATOM   1235 C CB   . VAL A 1 86  ? 29.26458 -7.50292  20.41401  1.000 22.77347  ? 81  VAL A CB   1 
ATOM   1236 C CG1  . VAL A 1 86  ? 28.27648 -6.42777  19.96111  1.000 40.44199  ? 81  VAL A CG1  1 
ATOM   1237 C CG2  . VAL A 1 86  ? 28.59883 -8.82800  20.23130  1.000 34.84482  ? 81  VAL A CG2  1 
ATOM   1238 H H    . VAL A 1 86  ? 31.28331 -8.97268  20.55197  1.000 30.66047  ? 81  VAL A H    1 
ATOM   1239 H HA   . VAL A 1 86  ? 30.29759 -7.48872  18.64354  1.000 38.67882  ? 81  VAL A HA   1 
ATOM   1240 H HB   . VAL A 1 86  ? 29.50562 -7.38694  21.34639  1.000 27.35056  ? 81  VAL A HB   1 
ATOM   1241 H HG11 . VAL A 1 86  ? 27.47104 -6.49290  20.49770  1.000 48.55279  ? 81  VAL A HG11 1 
ATOM   1242 H HG12 . VAL A 1 86  ? 28.68313 -5.55512  20.07947  1.000 48.55279  ? 81  VAL A HG12 1 
ATOM   1243 H HG13 . VAL A 1 86  ? 28.06296 -6.56905  19.02551  1.000 48.55279  ? 81  VAL A HG13 1 
ATOM   1244 H HG21 . VAL A 1 86  ? 27.84393 -8.88838  20.83743  1.000 41.83618  ? 81  VAL A HG21 1 
ATOM   1245 H HG22 . VAL A 1 86  ? 28.29329 -8.90407  19.31383  1.000 41.83618  ? 81  VAL A HG22 1 
ATOM   1246 H HG23 . VAL A 1 86  ? 29.23712 -9.53174  20.42680  1.000 41.83618  ? 81  VAL A HG23 1 
ATOM   1247 N N    . ARG A 1 87  ? 31.94388 -5.92228  20.92452  1.000 28.03943  ? 82  ARG A N    1 
ATOM   1248 C CA   . ARG A 1 87  ? 32.57632 -4.64956  21.23170  1.000 19.20058  ? 82  ARG A CA   1 
ATOM   1249 C C    . ARG A 1 87  ? 33.73383 -4.36638  20.29522  1.000 24.54668  ? 82  ARG A C    1 
ATOM   1250 O O    . ARG A 1 87  ? 34.01072 -3.19779  20.01235  1.000 44.29165  ? 82  ARG A O    1 
ATOM   1251 C CB   . ARG A 1 87  ? 33.05378 -4.63027  22.68606  1.000 36.37880  ? 82  ARG A CB   1 
ATOM   1252 C CG   . ARG A 1 87  ? 33.83034 -3.38083  23.09728  1.000 48.98686  ? 82  ARG A CG   1 
ATOM   1253 C CD   . ARG A 1 87  ? 34.82969 -3.64980  24.22860  1.000 34.93564  ? 82  ARG A CD   1 
ATOM   1254 N NE   . ARG A 1 87  ? 35.74087 -4.75514  23.93471  1.000 46.16744  ? 82  ARG A NE   1 
ATOM   1255 C CZ   . ARG A 1 87  ? 36.97021 -4.61431  23.44857  1.000 46.52583  ? 82  ARG A CZ   1 
ATOM   1256 N NH1  . ARG A 1 87  ? 37.45261 -3.43136  23.11078  1.000 58.66508  ? 82  ARG A NH1  1 
ATOM   1257 N NH2  . ARG A 1 87  ? 37.74224 -5.68483  23.31722  1.000 39.81059  ? 82  ARG A NH2  1 
ATOM   1258 H H    . ARG A 1 87  ? 32.07494 -6.53958  21.50879  1.000 33.66972  ? 82  ARG A H    1 
ATOM   1259 H HA   . ARG A 1 87  ? 31.92029 -3.94292  21.12595  1.000 23.06310  ? 82  ARG A HA   1 
ATOM   1260 H HB2  . ARG A 1 87  ? 32.27753 -4.69301  23.26432  1.000 43.67696  ? 82  ARG A HB2  1 
ATOM   1261 H HB3  . ARG A 1 87  ? 33.63558 -5.39338  22.82776  1.000 43.67696  ? 82  ARG A HB3  1 
ATOM   1262 H HG2  . ARG A 1 87  ? 34.32607 -3.05002  22.33196  1.000 58.80663  ? 82  ARG A HG2  1 
ATOM   1263 H HG3  . ARG A 1 87  ? 33.20478 -2.70603  23.40425  1.000 58.80663  ? 82  ARG A HG3  1 
ATOM   1264 H HD2  . ARG A 1 87  ? 35.36355 -2.85307  24.37392  1.000 41.94517  ? 82  ARG A HD2  1 
ATOM   1265 H HD3  . ARG A 1 87  ? 34.33998 -3.87278  25.03566  1.000 41.94517  ? 82  ARG A HD3  1 
ATOM   1266 H HE   . ARG A 1 87  ? 35.46131 -5.55398  24.08738  1.000 55.42332  ? 82  ARG A HE   1 
ATOM   1267 H HH11 . ARG A 1 87  ? 36.96800 -2.72697  23.20335  1.000 70.42049  ? 82  ARG A HH11 1 
ATOM   1268 H HH12 . ARG A 1 87  ? 38.25118 -3.36589  22.79838  1.000 70.42049  ? 82  ARG A HH12 1 
ATOM   1269 H HH21 . ARG A 1 87  ? 37.44601 -6.45925  23.54551  1.000 47.79510  ? 82  ARG A HH21 1 
ATOM   1270 H HH22 . ARG A 1 87  ? 38.53905 -5.60451  23.00377  1.000 47.79510  ? 82  ARG A HH22 1 
ATOM   1271 N N    . GLU A 1 88  ? 34.42939 -5.39778  19.81094  1.000 15.06156  ? 83  GLU A N    1 
ATOM   1272 C CA   . GLU A 1 88  ? 35.48416 -5.14916  18.82749  1.000 27.57069  ? 83  GLU A CA   1 
ATOM   1273 C C    . GLU A 1 88  ? 34.90748 -4.65684  17.49782  1.000 20.44172  ? 83  GLU A C    1 
ATOM   1274 O O    . GLU A 1 88  ? 35.45559 -3.73040  16.89190  1.000 30.55190  ? 83  GLU A O    1 
ATOM   1275 C CB   . GLU A 1 88  ? 36.32979 -6.40528  18.57411  1.000 21.74756  ? 83  GLU A CB   1 
ATOM   1276 C CG   . GLU A 1 88  ? 37.12502 -6.92173  19.76190  1.000 27.98974  ? 83  GLU A CG   1 
ATOM   1277 C CD   . GLU A 1 88  ? 37.80923 -8.27047  19.46715  1.000 51.71832  ? 83  GLU A CD   1 
ATOM   1278 O OE1  . GLU A 1 88  ? 37.31675 -8.99554  18.53780  1.000 22.46356  ? 83  GLU A OE1  1 
ATOM   1279 O OE2  . GLU A 1 88  ? 38.83592 -8.57743  20.16068  1.000 21.41059  ? 83  GLU A OE2  1 
ATOM   1280 H H    . GLU A 1 88  ? 34.31468 -6.22213  20.02746  1.000 18.09628  ? 83  GLU A H    1 
ATOM   1281 H HA   . GLU A 1 88  ? 36.06395 -4.46665  19.20021  1.000 33.10722  ? 83  GLU A HA   1 
ATOM   1282 H HB2  . GLU A 1 88  ? 35.73596 -7.11936  18.29419  1.000 26.11947  ? 83  GLU A HB2  1 
ATOM   1283 H HB3  . GLU A 1 88  ? 36.96488 -6.20616  17.86848  1.000 26.11947  ? 83  GLU A HB3  1 
ATOM   1284 H HG2  . GLU A 1 88  ? 37.81375 -6.27704  19.98756  1.000 33.61009  ? 83  GLU A HG2  1 
ATOM   1285 H HG3  . GLU A 1 88  ? 36.52662 -7.04532  20.51525  1.000 33.61009  ? 83  GLU A HG3  1 
ATOM   1286 N N    . TYR A 1 89  ? 33.80305 -5.25592  17.02978  1.000 14.05270  ? 84  TYR A N    1 
ATOM   1287 C CA   . TYR A 1 89  ? 33.28784 -4.91572  15.70251  1.000 35.14052  ? 84  TYR A CA   1 
ATOM   1288 C C    . TYR A 1 89  ? 32.56680 -3.55924  15.71045  1.000 28.32459  ? 84  TYR A C    1 
ATOM   1289 O O    . TYR A 1 89  ? 32.71745 -2.77074  14.76201  1.000 22.13176  ? 84  TYR A O    1 
ATOM   1290 C CB   . TYR A 1 89  ? 32.38833 -6.06219  15.18117  1.000 18.06947  ? 84  TYR A CB   1 
ATOM   1291 C CG   . TYR A 1 89  ? 31.87129 -5.81752  13.77052  1.000 19.19857  ? 84  TYR A CG   1 
ATOM   1292 C CD1  . TYR A 1 89  ? 32.71242 -5.36263  12.80657  1.000 6.57328   ? 84  TYR A CD1  1 
ATOM   1293 C CD2  . TYR A 1 89  ? 30.54779 -6.02971  13.43428  1.000 16.03132  ? 84  TYR A CD2  1 
ATOM   1294 C CE1  . TYR A 1 89  ? 32.27742 -5.10390  11.53873  1.000 18.57581  ? 84  TYR A CE1  1 
ATOM   1295 C CE2  . TYR A 1 89  ? 30.09542 -5.77966  12.16468  1.000 20.79376  ? 84  TYR A CE2  1 
ATOM   1296 C CZ   . TYR A 1 89  ? 30.97610 -5.30530  11.22766  1.000 15.40723  ? 84  TYR A CZ   1 
ATOM   1297 O OH   . TYR A 1 89  ? 30.59195 -5.02316  9.95508   1.000 14.53898  ? 84  TYR A OH   1 
ATOM   1298 H H    . TYR A 1 89  ? 33.34598 -5.84871  17.45322  1.000 16.88565  ? 84  TYR A H    1 
ATOM   1299 H HA   . TYR A 1 89  ? 34.02332 -4.83230  15.07560  1.000 42.19102  ? 84  TYR A HA   1 
ATOM   1300 H HB2  . TYR A 1 89  ? 32.90074 -6.88577  15.17355  1.000 21.70577  ? 84  TYR A HB2  1 
ATOM   1301 H HB3  . TYR A 1 89  ? 31.62226 -6.15351  15.76914  1.000 21.70577  ? 84  TYR A HB3  1 
ATOM   1302 H HD1  . TYR A 1 89  ? 33.60796 -5.22374  13.01543  1.000 7.91034   ? 84  TYR A HD1  1 
ATOM   1303 H HD2  . TYR A 1 89  ? 29.95604 -6.34641  14.07804  1.000 19.25999  ? 84  TYR A HD2  1 
ATOM   1304 H HE1  . TYR A 1 89  ? 32.87065 -4.79176  10.89411  1.000 22.31337  ? 84  TYR A HE1  1 
ATOM   1305 H HE2  . TYR A 1 89  ? 29.20485 -5.92954  11.94259  1.000 24.97492  ? 84  TYR A HE2  1 
ATOM   1306 H HH   . TYR A 1 89  ? 29.76866 -4.85789  9.93346   1.000 17.46918  ? 84  TYR A HH   1 
ATOM   1307 N N    . ARG A 1 90  ? 31.81604 -3.26068  16.78718  1.000 12.30931  ? 85  ARG A N    1 
ATOM   1308 C CA   . ARG A 1 90  ? 31.22240 -1.93088  16.97087  1.000 24.49507  ? 85  ARG A CA   1 
ATOM   1309 C C    . ARG A 1 90  ? 32.28178 -0.83505  17.02285  1.000 18.39209  ? 85  ARG A C    1 
ATOM   1310 O O    . ARG A 1 90  ? 32.09836 0.25682   16.47707  1.000 22.82623  ? 85  ARG A O    1 
ATOM   1311 C CB   . ARG A 1 90  ? 30.42024 -1.89517  18.25905  1.000 9.31575   ? 85  ARG A CB   1 
ATOM   1312 C CG   . ARG A 1 90  ? 29.58731 -0.66145  18.42327  1.000 18.54319  ? 85  ARG A CG   1 
ATOM   1313 C CD   . ARG A 1 90  ? 30.25895 0.43703   19.28229  1.000 31.69585  ? 85  ARG A CD   1 
ATOM   1314 N NE   . ARG A 1 90  ? 30.59379 0.00614   20.63436  1.000 7.81606   ? 85  ARG A NE   1 
ATOM   1315 C CZ   . ARG A 1 90  ? 31.59692 0.46936   21.37541  1.000 25.24378  ? 85  ARG A CZ   1 
ATOM   1316 N NH1  . ARG A 1 90  ? 32.34350 1.49177   20.98737  1.000 18.49520  ? 85  ARG A NH1  1 
ATOM   1317 N NH2  . ARG A 1 90  ? 31.87576 -0.12856  22.53345  1.000 21.47695  ? 85  ARG A NH2  1 
ATOM   1318 H H    . ARG A 1 90  ? 31.63734 -3.81142  17.42306  1.000 14.79357  ? 85  ARG A H    1 
ATOM   1319 H HA   . ARG A 1 90  ? 30.63632 -1.76222  16.21658  1.000 29.41648  ? 85  ARG A HA   1 
ATOM   1320 H HB2  . ARG A 1 90  ? 29.82263 -2.65905  18.27448  1.000 11.20130  ? 85  ARG A HB2  1 
ATOM   1321 H HB3  . ARG A 1 90  ? 31.03404 -1.93893  19.00887  1.000 11.20130  ? 85  ARG A HB3  1 
ATOM   1322 H HG2  . ARG A 1 90  ? 29.41157 -0.28431  17.54704  1.000 22.27423  ? 85  ARG A HG2  1 
ATOM   1323 H HG3  . ARG A 1 90  ? 28.75245 -0.90327  18.85389  1.000 22.27423  ? 85  ARG A HG3  1 
ATOM   1324 H HD2  . ARG A 1 90  ? 31.08142 0.71307   18.84842  1.000 38.05742  ? 85  ARG A HD2  1 
ATOM   1325 H HD3  . ARG A 1 90  ? 29.65277 1.19084   19.35449  1.000 38.05742  ? 85  ARG A HD3  1 
ATOM   1326 H HE   . ARG A 1 90  ? 30.09775 -0.60282  20.98468  1.000 9.40168   ? 85  ARG A HE   1 
ATOM   1327 H HH11 . ARG A 1 90  ? 32.18633 1.87795   20.23520  1.000 22.21664  ? 85  ARG A HH11 1 
ATOM   1328 H HH12 . ARG A 1 90  ? 32.98556 1.76964   21.48751  1.000 22.21664  ? 85  ARG A HH12 1 
ATOM   1329 H HH21 . ARG A 1 90  ? 31.40990 -0.80366  22.79193  1.000 25.79474  ? 85  ARG A HH21 1 
ATOM   1330 H HH22 . ARG A 1 90  ? 32.52154 0.16072   23.02220  1.000 25.79474  ? 85  ARG A HH22 1 
ATOM   1331 N N    . GLU A 1 91  ? 33.38477 -1.11020  17.70064  1.000 23.92907  ? 86  GLU A N    1 
ATOM   1332 C CA   . GLU A 1 91  ? 34.51631 -0.20592  17.72538  1.000 12.54924  ? 86  GLU A CA   1 
ATOM   1333 C C    . GLU A 1 91  ? 35.07484 0.05167   16.33677  1.000 27.09055  ? 86  GLU A C    1 
ATOM   1334 O O    . GLU A 1 91  ? 35.57470 1.15242   16.06280  1.000 33.32951  ? 86  GLU A O    1 
ATOM   1335 C CB   . GLU A 1 91  ? 35.59687 -0.80696  18.62971  1.000 16.87050  ? 86  GLU A CB   1 
ATOM   1336 C CG   . GLU A 1 91  ? 35.42959 -0.51085  20.09282  1.000 31.72420  ? 86  GLU A CG   1 
ATOM   1337 C CD   . GLU A 1 91  ? 36.65920 -0.90166  20.93478  1.000 65.96034  ? 86  GLU A CD   1 
ATOM   1338 O OE1  . GLU A 1 91  ? 37.59597 -1.54400  20.39041  1.000 50.24781  ? 86  GLU A OE1  1 
ATOM   1339 O OE2  . GLU A 1 91  ? 36.68117 -0.55872  22.14972  1.000 42.55504  ? 86  GLU A OE2  1 
ATOM   1340 H H    . GLU A 1 91  ? 33.50473 -1.82600  18.16199  1.000 28.73729  ? 86  GLU A H    1 
ATOM   1341 H HA   . GLU A 1 91  ? 34.23683 0.65134   18.08299  1.000 15.08149  ? 86  GLU A HA   1 
ATOM   1342 H HB2  . GLU A 1 91  ? 35.58546 -1.77112  18.52399  1.000 20.26700  ? 86  GLU A HB2  1 
ATOM   1343 H HB3  . GLU A 1 91  ? 36.45805 -0.45349  18.35708  1.000 20.26700  ? 86  GLU A HB3  1 
ATOM   1344 H HG2  . GLU A 1 91  ? 35.28094 0.44098   20.20609  1.000 38.09144  ? 86  GLU A HG2  1 
ATOM   1345 H HG3  . GLU A 1 91  ? 34.66762 -1.00798  20.42922  1.000 38.09144  ? 86  GLU A HG3  1 
ATOM   1346 N N    . LYS A 1 92  ? 35.02505 -0.94552  15.44981  1.000 26.21280  ? 87  LYS A N    1 
ATOM   1347 C CA   . LYS A 1 92  ? 35.66613 -0.79826  14.14388  1.000 24.45355  ? 87  LYS A CA   1 
ATOM   1348 C C    . LYS A 1 92  ? 34.81236 0.07995   13.22565  1.000 30.42897  ? 87  LYS A C    1 
ATOM   1349 O O    . LYS A 1 92  ? 35.31677 1.00462   12.56279  1.000 10.05953  ? 87  LYS A O    1 
ATOM   1350 C CB   . LYS A 1 92  ? 35.91338 -2.20023  13.56295  1.000 26.66417  ? 87  LYS A CB   1 
ATOM   1351 C CG   . LYS A 1 92  ? 36.48428 -2.28244  12.14041  1.000 47.13639  ? 87  LYS A CG   1 
ATOM   1352 C CD   . LYS A 1 92  ? 36.39286 -3.71565  11.61244  1.000 64.60381  ? 87  LYS A CD   1 
ATOM   1353 C CE   . LYS A 1 92  ? 36.35881 -3.74691  10.09335  1.000 58.32705  ? 87  LYS A CE   1 
ATOM   1354 N NZ   . LYS A 1 92  ? 35.08564 -3.19767  9.54762   1.000 55.90486  ? 87  LYS A NZ   1 
ATOM   1355 H H    . LYS A 1 92  ? 34.63455 -1.70100  15.57773  1.000 31.47776  ? 87  LYS A H    1 
ATOM   1356 H HA   . LYS A 1 92  ? 36.52857 -0.36129  14.22232  1.000 29.36666  ? 87  LYS A HA   1 
ATOM   1357 H HB2  . LYS A 1 92  ? 36.54115 -2.65717  14.14434  1.000 32.01940  ? 87  LYS A HB2  1 
ATOM   1358 H HB3  . LYS A 1 92  ? 35.06610 -2.67238  13.55324  1.000 32.01940  ? 87  LYS A HB3  1 
ATOM   1359 H HG2  . LYS A 1 92  ? 35.97640 -1.70252  11.55164  1.000 56.58606  ? 87  LYS A HG2  1 
ATOM   1360 H HG3  . LYS A 1 92  ? 37.41633 -2.01388  12.14751  1.000 56.58606  ? 87  LYS A HG3  1 
ATOM   1361 H HD2  . LYS A 1 92  ? 37.16708 -4.21817  11.91068  1.000 77.54698  ? 87  LYS A HD2  1 
ATOM   1362 H HD3  . LYS A 1 92  ? 35.58076 -4.12941  11.94441  1.000 77.54698  ? 87  LYS A HD3  1 
ATOM   1363 H HE2  . LYS A 1 92  ? 37.09105 -3.21308  9.74731   1.000 70.01487  ? 87  LYS A HE2  1 
ATOM   1364 H HE3  . LYS A 1 92  ? 36.44583 -4.66468  9.79165   1.000 70.01487  ? 87  LYS A HE3  1 
ATOM   1365 H HZ1  . LYS A 1 92  ? 35.07009 -3.28754  8.66230   1.000 67.10824  ? 87  LYS A HZ1  1 
ATOM   1366 H HZ2  . LYS A 1 92  ? 34.39219 -3.63459  9.89452   1.000 67.10824  ? 87  LYS A HZ2  1 
ATOM   1367 H HZ3  . LYS A 1 92  ? 35.01440 -2.33429  9.75159   1.000 67.10824  ? 87  LYS A HZ3  1 
ATOM   1368 N N    . VAL A 1 93  ? 33.51416 -0.19366  13.19403  1.000 14.33248  ? 88  VAL A N    1 
ATOM   1369 C CA   . VAL A 1 93  ? 32.57389 0.65788   12.47470  1.000 16.63536  ? 88  VAL A CA   1 
ATOM   1370 C C    . VAL A 1 93  ? 32.67804 2.09658   12.96774  1.000 12.94516  ? 88  VAL A C    1 
ATOM   1371 O O    . VAL A 1 93  ? 32.80722 3.01986   12.15934  1.000 19.39980  ? 88  VAL A O    1 
ATOM   1372 C CB   . VAL A 1 93  ? 31.14482 0.09615   12.61689  1.000 23.32007  ? 88  VAL A CB   1 
ATOM   1373 C CG1  . VAL A 1 93  ? 30.16769 0.91715   11.83883  1.000 13.15730  ? 88  VAL A CG1  1 
ATOM   1374 C CG2  . VAL A 1 93  ? 31.08035 -1.33173  12.12299  1.000 21.34590  ? 88  VAL A CG2  1 
ATOM   1375 H H    . VAL A 1 93  ? 33.14892 -0.86874  13.58194  1.000 17.22138  ? 88  VAL A H    1 
ATOM   1376 H HA   . VAL A 1 93  ? 32.80222 0.65897   11.53196  1.000 19.98484  ? 88  VAL A HA   1 
ATOM   1377 H HB   . VAL A 1 93  ? 30.90806 0.12434   13.55713  1.000 28.00648  ? 88  VAL A HB   1 
ATOM   1378 H HG11 . VAL A 1 93  ? 30.64076 1.64509   11.40616  1.000 15.81116  ? 88  VAL A HG11 1 
ATOM   1379 H HG12 . VAL A 1 93  ? 29.74383 0.35516   11.17145  1.000 15.81116  ? 88  VAL A HG12 1 
ATOM   1380 H HG13 . VAL A 1 93  ? 29.49915 1.27158   12.44574  1.000 15.81116  ? 88  VAL A HG13 1 
ATOM   1381 H HG21 . VAL A 1 93  ? 30.15571 -1.62488  12.12424  1.000 25.63748  ? 88  VAL A HG21 1 
ATOM   1382 H HG22 . VAL A 1 93  ? 31.43854 -1.37085  11.22240  1.000 25.63748  ? 88  VAL A HG22 1 
ATOM   1383 H HG23 . VAL A 1 93  ? 31.60642 -1.89400  12.71291  1.000 25.63748  ? 88  VAL A HG23 1 
ATOM   1384 N N    . GLU A 1 94  ? 32.67278 2.29528   14.30210  1.000 18.69135  ? 89  GLU A N    1 
ATOM   1385 C CA   . GLU A 1 94  ? 32.67026 3.63137   14.90588  1.000 8.14573   ? 89  GLU A CA   1 
ATOM   1386 C C    . GLU A 1 94  ? 33.87110 4.43229   14.45240  1.000 17.10329  ? 89  GLU A C    1 
ATOM   1387 O O    . GLU A 1 94  ? 33.76029 5.60840   14.10261  1.000 19.40275  ? 89  GLU A O    1 
ATOM   1388 C CB   . GLU A 1 94  ? 32.64762 3.49581   16.44375  1.000 43.23117  ? 89  GLU A CB   1 
ATOM   1389 C CG   . GLU A 1 94  ? 32.68059 4.80379   17.30517  1.000 23.92071  ? 89  GLU A CG   1 
ATOM   1390 C CD   . GLU A 1 94  ? 32.69620 4.57928   18.85194  1.000 24.26167  ? 89  GLU A CD   1 
ATOM   1391 O OE1  . GLU A 1 94  ? 31.74729 3.98044   19.38905  1.000 16.62681  ? 89  GLU A OE1  1 
ATOM   1392 O OE2  . GLU A 1 94  ? 33.63975 5.04782   19.53188  1.000 17.51082  ? 89  GLU A OE2  1 
ATOM   1393 H H    . GLU A 1 94  ? 32.67057 1.66118   14.88306  1.000 22.45202  ? 89  GLU A H    1 
ATOM   1394 H HA   . GLU A 1 94  ? 31.87364 4.11174   14.63102  1.000 9.79727   ? 89  GLU A HA   1 
ATOM   1395 H HB2  . GLU A 1 94  ? 31.83420 3.02594   16.68554  1.000 51.89981  ? 89  GLU A HB2  1 
ATOM   1396 H HB3  . GLU A 1 94  ? 33.42238 2.97355   16.70430  1.000 51.89981  ? 89  GLU A HB3  1 
ATOM   1397 H HG2  . GLU A 1 94  ? 33.48091 5.30188   17.07649  1.000 28.72726  ? 89  GLU A HG2  1 
ATOM   1398 H HG3  . GLU A 1 94  ? 31.89211 5.32879   17.09643  1.000 28.72726  ? 89  GLU A HG3  1 
ATOM   1399 N N    . THR A 1 95  ? 35.02638 3.79582   14.42508  1.000 29.04952  ? 90  THR A N    1 
ATOM   1400 C CA   . THR A 1 95  ? 36.24045 4.40936   13.89486  1.000 17.96007  ? 90  THR A CA   1 
ATOM   1401 C C    . THR A 1 95  ? 36.17183 4.73245   12.39178  1.000 19.73004  ? 90  THR A C    1 
ATOM   1402 O O    . THR A 1 95  ? 36.91190 5.59945   11.91551  1.000 12.48584  ? 90  THR A O    1 
ATOM   1403 C CB   . THR A 1 95  ? 37.35971 3.42899   14.23072  1.000 31.72387  ? 90  THR A CB   1 
ATOM   1404 O OG1  . THR A 1 95  ? 37.39322 3.23108   15.65264  1.000 34.40293  ? 90  THR A OG1  1 
ATOM   1405 C CG2  . THR A 1 95  ? 38.67011 3.90164   13.77673  1.000 24.37787  ? 90  THR A CG2  1 
ATOM   1406 H H    . THR A 1 95  ? 35.14324 2.99321   14.71101  1.000 34.88183  ? 90  THR A H    1 
ATOM   1407 H HA   . THR A 1 95  ? 36.41422 5.27310   14.30065  1.000 21.57449  ? 90  THR A HA   1 
ATOM   1408 H HB   . THR A 1 95  ? 37.18754 2.59137   13.77283  1.000 38.09105  ? 90  THR A HB   1 
ATOM   1409 H HG1  . THR A 1 95  ? 36.64352 2.96625   15.92360  1.000 41.30591  ? 90  THR A HG1  1 
ATOM   1410 H HG21 . THR A 1 95  ? 39.35242 3.24743   13.99437  1.000 29.27585  ? 90  THR A HG21 1 
ATOM   1411 H HG22 . THR A 1 95  ? 38.65928 4.03761   12.81636  1.000 29.27585  ? 90  THR A HG22 1 
ATOM   1412 H HG23 . THR A 1 95  ? 38.88878 4.74095   14.21105  1.000 29.27585  ? 90  THR A HG23 1 
ATOM   1413 N N    . GLU A 1 96  ? 35.31395 4.06013   11.63089  1.000 14.34527  ? 91  GLU A N    1 
ATOM   1414 C CA   . GLU A 1 96  ? 35.17844 4.37372   10.21655  1.000 25.04503  ? 91  GLU A CA   1 
ATOM   1415 C C    . GLU A 1 96  ? 34.36102 5.64073   10.03058  1.000 17.72949  ? 91  GLU A C    1 
ATOM   1416 O O    . GLU A 1 96  ? 34.68600 6.48187   9.18838   1.000 17.16465  ? 91  GLU A O    1 
ATOM   1417 C CB   . GLU A 1 96  ? 34.51831 3.20323   9.49641   1.000 33.95704  ? 91  GLU A CB   1 
ATOM   1418 C CG   . GLU A 1 96  ? 35.18723 2.76858   8.22109   1.000 46.71589  ? 91  GLU A CG   1 
ATOM   1419 C CD   . GLU A 1 96  ? 34.72385 1.38578   7.78506   1.000 36.33085  ? 91  GLU A CD   1 
ATOM   1420 O OE1  . GLU A 1 96  ? 35.29882 0.38658   8.28919   1.000 37.64625  ? 91  GLU A OE1  1 
ATOM   1421 O OE2  . GLU A 1 96  ? 33.77685 1.31063   6.95900   1.000 23.96371  ? 91  GLU A OE2  1 
ATOM   1422 H H    . GLU A 1 96  ? 34.80456 3.42471   11.90724  1.000 17.23672  ? 91  GLU A H    1 
ATOM   1423 H HA   . GLU A 1 96  ? 36.05451 4.51114   9.82347   1.000 30.07644  ? 91  GLU A HA   1 
ATOM   1424 H HB2  . GLU A 1 96  ? 34.51388 2.43993   10.09497  1.000 40.77085  ? 91  GLU A HB2  1 
ATOM   1425 H HB3  . GLU A 1 96  ? 33.60854 3.45565   9.27394   1.000 40.77085  ? 91  GLU A HB3  1 
ATOM   1426 H HG2  . GLU A 1 96  ? 34.97135 3.39838   7.51565   1.000 56.08147  ? 91  GLU A HG2  1 
ATOM   1427 H HG3  . GLU A 1 96  ? 36.14719 2.73902   8.35711   1.000 56.08147  ? 91  GLU A HG3  1 
ATOM   1428 N N    . LEU A 1 97  ? 33.31058 5.77552   10.83423  1.000 19.83383  ? 92  LEU A N    1 
ATOM   1429 C CA   . LEU A 1 97  ? 32.46858 6.96741   10.82934  1.000 24.49576  ? 92  LEU A CA   1 
ATOM   1430 C C    . LEU A 1 97  ? 33.25225 8.20940   11.25966  1.000 26.85440  ? 92  LEU A C    1 
ATOM   1431 O O    . LEU A 1 97  ? 33.22132 9.24253   10.58691  1.000 18.16452  ? 92  LEU A O    1 
ATOM   1432 C CB   . LEU A 1 97  ? 31.25309 6.71107   11.74084  1.000 15.03161  ? 92  LEU A CB   1 
ATOM   1433 C CG   . LEU A 1 97  ? 30.15154 7.77333   11.85494  1.000 12.61406  ? 92  LEU A CG   1 
ATOM   1434 C CD1  . LEU A 1 97  ? 28.75626 7.19246   12.11446  1.000 21.47162  ? 92  LEU A CD1  1 
ATOM   1435 C CD2  . LEU A 1 97  ? 30.48638 8.74210   12.94953  1.000 37.66676  ? 92  LEU A CD2  1 
ATOM   1436 H H    . LEU A 1 97  ? 33.05828 5.18134   11.40247  1.000 23.82299  ? 92  LEU A H    1 
ATOM   1437 H HA   . LEU A 1 97  ? 32.14744 7.14294   9.93102   1.000 29.41732  ? 92  LEU A HA   1 
ATOM   1438 H HB2  . LEU A 1 97  ? 30.81953 5.90397   11.42224  1.000 18.06034  ? 92  LEU A HB2  1 
ATOM   1439 H HB3  . LEU A 1 97  ? 31.59119 6.57342   12.63952  1.000 18.06034  ? 92  LEU A HB3  1 
ATOM   1440 H HG   . LEU A 1 97  ? 30.11139 8.22336   10.99659  1.000 15.15927  ? 92  LEU A HG   1 
ATOM   1441 H HD11 . LEU A 1 97  ? 28.76573 6.71259   12.95739  1.000 25.78834  ? 92  LEU A HD11 1 
ATOM   1442 H HD12 . LEU A 1 97  ? 28.11432 7.91856   12.15439  1.000 25.78834  ? 92  LEU A HD12 1 
ATOM   1443 H HD13 . LEU A 1 97  ? 28.52670 6.58736   11.39192  1.000 25.78834  ? 92  LEU A HD13 1 
ATOM   1444 H HD21 . LEU A 1 97  ? 29.71094 9.29668   13.12856  1.000 45.22252  ? 92  LEU A HD21 1 
ATOM   1445 H HD22 . LEU A 1 97  ? 30.72946 8.24604   13.74686  1.000 45.22252  ? 92  LEU A HD22 1 
ATOM   1446 H HD23 . LEU A 1 97  ? 31.23027 9.29564   12.66472  1.000 45.22252  ? 92  LEU A HD23 1 
ATOM   1447 N N    . GLN A 1 98  ? 33.96724 8.13461   12.38067  1.000 24.05711  ? 93  GLN A N    1 
ATOM   1448 C CA   . GLN A 1 98  ? 34.76427 9.28289   12.79493  1.000 19.84292  ? 93  GLN A CA   1 
ATOM   1449 C C    . GLN A 1 98  ? 35.76079 9.69327   11.71335  1.000 18.51746  ? 93  GLN A C    1 
ATOM   1450 O O    . GLN A 1 98  ? 36.16586 10.85558  11.64003  1.000 21.42394  ? 93  GLN A O    1 
ATOM   1451 C CB   . GLN A 1 98  ? 35.50332 8.98196   14.10479  1.000 15.24451  ? 93  GLN A CB   1 
ATOM   1452 C CG   . GLN A 1 98  ? 34.61933 8.81456   15.33859  1.000 14.31869  ? 93  GLN A CG   1 
ATOM   1453 C CD   . GLN A 1 98  ? 35.36562 8.18767   16.52044  1.000 31.24194  ? 93  GLN A CD   1 
ATOM   1454 O OE1  . GLN A 1 98  ? 36.39921 7.54387   16.35049  1.000 36.19757  ? 93  GLN A OE1  1 
ATOM   1455 N NE2  . GLN A 1 98  ? 34.84380 8.38208   17.71674  1.000 32.73814  ? 93  GLN A NE2  1 
ATOM   1456 H H    . GLN A 1 98  ? 34.00641 7.45200   12.90231  1.000 28.89093  ? 93  GLN A H    1 
ATOM   1457 H HA   . GLN A 1 98  ? 34.16472 10.02803  12.95681  1.000 23.83390  ? 93  GLN A HA   1 
ATOM   1458 H HB2  . GLN A 1 98  ? 35.99949 8.15617   13.99168  1.000 18.31582  ? 93  GLN A HB2  1 
ATOM   1459 H HB3  . GLN A 1 98  ? 36.11389 9.71383   14.28499  1.000 18.31582  ? 93  GLN A HB3  1 
ATOM   1460 H HG2  . GLN A 1 98  ? 34.29551 9.68576   15.61618  1.000 17.20482  ? 93  GLN A HG2  1 
ATOM   1461 H HG3  . GLN A 1 98  ? 33.87158 8.23815   15.11604  1.000 17.20482  ? 93  GLN A HG3  1 
ATOM   1462 H HE21 . GLN A 1 98  ? 34.12129 8.84080   17.80135  1.000 39.30816  ? 93  GLN A HE21 1 
ATOM   1463 H HE22 . GLN A 1 98  ? 35.22622 8.05007   18.41181  1.000 39.30816  ? 93  GLN A HE22 1 
ATOM   1464 N N    . GLY A 1 99  ? 36.17076 8.77435   10.85203  1.000 35.61624  ? 94  GLY A N    1 
ATOM   1465 C CA   . GLY A 1 99  ? 37.14853 9.14234   9.84178   1.000 19.42869  ? 94  GLY A CA   1 
ATOM   1466 C C    . GLY A 1 99  ? 36.53534 9.86981   8.67120   1.000 12.10752  ? 94  GLY A C    1 
ATOM   1467 O O    . GLY A 1 99  ? 37.18395 10.72200  8.05833   1.000 10.06273  ? 94  GLY A O    1 
ATOM   1468 H H    . GLY A 1 99  ? 35.90705 7.95604   10.83121  1.000 42.76189  ? 94  GLY A H    1 
ATOM   1469 H HA2  . GLY A 1 99  ? 37.81829 9.71913   10.24133  1.000 23.33683  ? 94  GLY A HA2  1 
ATOM   1470 H HA3  . GLY A 1 99  ? 37.58054 8.34018   9.50892   1.000 23.33683  ? 94  GLY A HA3  1 
ATOM   1471 N N    . VAL A 1 100 ? 35.29049 9.55134   8.33355   1.000 12.73997  ? 95  VAL A N    1 
ATOM   1472 C CA   . VAL A 1 100 ? 34.61617 10.29752  7.27475   1.000 18.57274  ? 95  VAL A CA   1 
ATOM   1473 C C    . VAL A 1 100 ? 34.26109 11.69970  7.77389   1.000 13.63910  ? 95  VAL A C    1 
ATOM   1474 O O    . VAL A 1 100 ? 34.38956 12.68443  7.03608   1.000 21.66492  ? 95  VAL A O    1 
ATOM   1475 C CB   . VAL A 1 100 ? 33.38858 9.51038   6.79146   1.000 20.46976  ? 95  VAL A CB   1 
ATOM   1476 C CG1  . VAL A 1 100 ? 32.34161 10.40755  6.18527   1.000 6.54862   ? 95  VAL A CG1  1 
ATOM   1477 C CG2  . VAL A 1 100 ? 33.81434 8.44087   5.78423   1.000 16.48606  ? 95  VAL A CG2  1 
ATOM   1478 H H    . VAL A 1 100 ? 34.82414 8.92375   8.69167   1.000 15.31037  ? 95  VAL A H    1 
ATOM   1479 H HA   . VAL A 1 100 ? 35.21105 10.40276  6.51584   1.000 22.30969  ? 95  VAL A HA   1 
ATOM   1480 H HB   . VAL A 1 100 ? 32.98632 9.08263   7.56355   1.000 24.58611  ? 95  VAL A HB   1 
ATOM   1481 H HG11 . VAL A 1 100 ? 31.80741 10.79475  6.89632   1.000 7.88074   ? 95  VAL A HG11 1 
ATOM   1482 H HG12 . VAL A 1 100 ? 32.78120 11.11037  5.68157   1.000 7.88074   ? 95  VAL A HG12 1 
ATOM   1483 H HG13 . VAL A 1 100 ? 31.77767 9.88187   5.59660   1.000 7.88074   ? 95  VAL A HG13 1 
ATOM   1484 H HG21 . VAL A 1 100 ? 33.02467 7.98023   5.45997   1.000 19.80567  ? 95  VAL A HG21 1 
ATOM   1485 H HG22 . VAL A 1 100 ? 34.27468 8.86846   5.04521   1.000 19.80567  ? 95  VAL A HG22 1 
ATOM   1486 H HG23 . VAL A 1 100 ? 34.40737 7.81148   6.22363   1.000 19.80567  ? 95  VAL A HG23 1 
ATOM   1487 N N    . CYS A 1 101 ? 33.88733 11.81649  9.06257   1.000 26.17307  ? 96  CYS A N    1 
ATOM   1488 C CA   . CYS A 1 101 ? 33.54211 13.11073  9.64390   1.000 17.83066  ? 96  CYS A CA   1 
ATOM   1489 C C    . CYS A 1 101 ? 34.75633 14.01956  9.70134   1.000 16.03778  ? 96  CYS A C    1 
ATOM   1490 O O    . CYS A 1 101 ? 34.61349 15.22607  9.52061   1.000 24.92532  ? 96  CYS A O    1 
ATOM   1491 C CB   . CYS A 1 101 ? 32.94259 12.96447  11.04809  1.000 11.71338  ? 96  CYS A CB   1 
ATOM   1492 S SG   . CYS A 1 101 ? 31.22314 12.29233  11.17205  1.000 17.77667  ? 96  CYS A SG   1 
ATOM   1493 H H    . CYS A 1 101 ? 33.82799 11.15927  9.61405   1.000 31.43008  ? 96  CYS A H    1 
ATOM   1494 H HA   . CYS A 1 101 ? 32.85952 13.51369  9.08479   1.000 21.41919  ? 96  CYS A HA   1 
ATOM   1495 H HB2  . CYS A 1 101 ? 33.51468 12.36757  11.55537  1.000 14.07846  ? 96  CYS A HB2  1 
ATOM   1496 H HB3  . CYS A 1 101 ? 32.93119 13.84264  11.45989  1.000 14.07846  ? 96  CYS A HB3  1 
ATOM   1497 H HG   . CYS A 1 101 ? 30.86502 12.34399  12.31620  1.000 21.35440  ? 96  CYS A HG   1 
ATOM   1498 N N    . ASP A 1 102 ? 35.95426 13.45205  9.90179   1.000 12.41516  ? 97  ASP A N    1 
ATOM   1499 C CA   . ASP A 1 102 ? 37.15993 14.26572  9.93580   1.000 12.51989  ? 97  ASP A CA   1 
ATOM   1500 C C    . ASP A 1 102 ? 37.61383 14.67825  8.55926   1.000 15.41210  ? 97  ASP A C    1 
ATOM   1501 O O    . ASP A 1 102 ? 38.31081 15.69347  8.43789   1.000 10.58019  ? 97  ASP A O    1 
ATOM   1502 C CB   . ASP A 1 102 ? 38.30874 13.53553  10.63942  1.000 18.02823  ? 97  ASP A CB   1 
ATOM   1503 C CG   . ASP A 1 102 ? 38.19056 13.59627  12.17202  1.000 36.89549  ? 97  ASP A CG   1 
ATOM   1504 O OD1  . ASP A 1 102 ? 37.83802 14.67856  12.69322  1.000 48.79266  ? 97  ASP A OD1  1 
ATOM   1505 O OD2  . ASP A 1 102 ? 38.43437 12.55582  12.85371  1.000 27.94810  ? 97  ASP A OD2  1 
ATOM   1506 H H    . ASP A 1 102 ? 36.08650 12.61030  10.01829  1.000 14.92059  ? 97  ASP A H    1 
ATOM   1507 H HA   . ASP A 1 102 ? 36.95263 15.06156  10.45016  1.000 15.04626  ? 97  ASP A HA   1 
ATOM   1508 H HB2  . ASP A 1 102 ? 38.30231 12.60277  10.37331  1.000 21.65627  ? 97  ASP A HB2  1 
ATOM   1509 H HB3  . ASP A 1 102 ? 39.14948 13.94722  10.38535  1.000 21.65627  ? 97  ASP A HB3  1 
ATOM   1510 N N    . THR A 1 103 ? 37.25766 13.88139  7.52802   1.000 16.12618  ? 98  THR A N    1 
ATOM   1511 C CA   . THR A 1 103 ? 37.59708 14.20765  6.14737   1.000 13.87304  ? 98  THR A CA   1 
ATOM   1512 C C    . THR A 1 103 ? 36.77013 15.40111  5.64144   1.000 18.79232  ? 98  THR A C    1 
ATOM   1513 O O    . THR A 1 103 ? 37.31983 16.36699  5.10920   1.000 13.46366  ? 98  THR A O    1 
ATOM   1514 C CB   . THR A 1 103 ? 37.39660 12.96073  5.27208   1.000 10.60163  ? 98  THR A CB   1 
ATOM   1515 O OG1  . THR A 1 103 ? 38.46446 12.04694  5.50811   1.000 20.39040  ? 98  THR A OG1  1 
ATOM   1516 C CG2  . THR A 1 103 ? 37.40407 13.30098  3.76181   1.000 25.36941  ? 98  THR A CG2  1 
ATOM   1517 H H    . THR A 1 103 ? 36.81829 13.14687  7.61185   1.000 19.37381  ? 98  THR A H    1 
ATOM   1518 H HA   . THR A 1 103 ? 38.53034 14.46565  6.08935   1.000 16.67005  ? 98  THR A HA   1 
ATOM   1519 H HB   . THR A 1 103 ? 36.53688 12.57114  5.49571   1.000 12.74435  ? 98  THR A HB   1 
ATOM   1520 H HG1  . THR A 1 103 ? 38.56348 11.92784  6.33371   1.000 24.49089  ? 98  THR A HG1  1 
ATOM   1521 H HG21 . THR A 1 103 ? 38.11610 13.93024  3.56702   1.000 30.46569  ? 98  THR A HG21 1 
ATOM   1522 H HG22 . THR A 1 103 ? 37.54502 12.49498  3.24085   1.000 30.46569  ? 98  THR A HG22 1 
ATOM   1523 H HG23 . THR A 1 103 ? 36.55590 13.69644  3.50663   1.000 30.46569  ? 98  THR A HG23 1 
ATOM   1524 N N    . VAL A 1 104 ? 35.45084 15.37074  5.82379   1.000 16.96142  ? 99  VAL A N    1 
ATOM   1525 C CA   . VAL A 1 104 ? 34.63598 16.53990  5.49118   1.000 5.97308   ? 99  VAL A CA   1 
ATOM   1526 C C    . VAL A 1 104 ? 35.11986 17.77162  6.26197   1.000 21.08703  ? 99  VAL A C    1 
ATOM   1527 O O    . VAL A 1 104 ? 35.51701 18.78297  5.67022   1.000 30.04768  ? 99  VAL A O    1 
ATOM   1528 C CB   . VAL A 1 104 ? 33.15086 16.24915  5.76992   1.000 12.16900  ? 99  VAL A CB   1 
ATOM   1529 C CG1  . VAL A 1 104 ? 32.31691 17.49510  5.60686   1.000 8.20246   ? 99  VAL A CG1  1 
ATOM   1530 C CG2  . VAL A 1 104 ? 32.63945 15.13553  4.84450   1.000 33.39317  ? 99  VAL A CG2  1 
ATOM   1531 H H    . VAL A 1 104 ? 35.01058 14.69953  6.13242   1.000 20.37610  ? 99  VAL A H    1 
ATOM   1532 H HA   . VAL A 1 104 ? 34.73788 16.72801  4.54507   1.000 7.19010   ? 99  VAL A HA   1 
ATOM   1533 H HB   . VAL A 1 104 ? 33.06272 15.94971  6.68832   1.000 14.62520  ? 99  VAL A HB   1 
ATOM   1534 H HG11 . VAL A 1 104 ? 31.38175 17.24392  5.54954   1.000 9.86535   ? 99  VAL A HG11 1 
ATOM   1535 H HG12 . VAL A 1 104 ? 32.45802 18.07215  6.37367   1.000 9.86535   ? 99  VAL A HG12 1 
ATOM   1536 H HG13 . VAL A 1 104 ? 32.58707 17.95192  4.79494   1.000 9.86535   ? 99  VAL A HG13 1 
ATOM   1537 H HG21 . VAL A 1 104 ? 31.69147 15.00410  5.00250   1.000 40.09420  ? 99  VAL A HG21 1 
ATOM   1538 H HG22 . VAL A 1 104 ? 32.78785 15.39803  3.92256   1.000 40.09420  ? 99  VAL A HG22 1 
ATOM   1539 H HG23 . VAL A 1 104 ? 33.12350 14.31739  5.03749   1.000 40.09420  ? 99  VAL A HG23 1 
ATOM   1540 N N    . LEU A 1 105 ? 35.10197 17.70893  7.60329   1.000 25.31733  ? 100 LEU A N    1 
ATOM   1541 C CA   . LEU A 1 105 ? 35.51058 18.86331  8.39696   1.000 13.52773  ? 100 LEU A CA   1 
ATOM   1542 C C    . LEU A 1 105 ? 36.83885 19.46597  7.92090   1.000 15.83491  ? 100 LEU A C    1 
ATOM   1543 O O    . LEU A 1 105 ? 37.09782 20.66468  8.10722   1.000 15.75985  ? 100 LEU A O    1 
ATOM   1544 C CB   . LEU A 1 105 ? 35.57941 18.45551  9.88501   1.000 38.70482  ? 100 LEU A CB   1 
ATOM   1545 C CG   . LEU A 1 105 ? 34.22974 18.24917  10.61618  1.000 17.82473  ? 100 LEU A CG   1 
ATOM   1546 C CD1  . LEU A 1 105 ? 34.36987 17.56849  11.97136  1.000 7.72775   ? 100 LEU A CD1  1 
ATOM   1547 C CD2  . LEU A 1 105 ? 33.47726 19.57294  10.74796  1.000 17.68711  ? 100 LEU A CD2  1 
ATOM   1548 H H    . LEU A 1 105 ? 34.86181 17.02231  8.06206   1.000 30.40320  ? 100 LEU A H    1 
ATOM   1549 H HA   . LEU A 1 105 ? 34.84722 19.56614  8.31400   1.000 16.25568  ? 100 LEU A HA   1 
ATOM   1550 H HB2  . LEU A 1 105 ? 36.06466 17.61765  9.94346   1.000 46.46818  ? 100 LEU A HB2  1 
ATOM   1551 H HB3  . LEU A 1 105 ? 36.05806 19.15020  10.36376  1.000 46.46818  ? 100 LEU A HB3  1 
ATOM   1552 H HG   . LEU A 1 105 ? 33.70465 17.64336  10.07012  1.000 21.41208  ? 100 LEU A HG   1 
ATOM   1553 H HD11 . LEU A 1 105 ? 33.48567 17.39175  12.32892  1.000 9.29570   ? 100 LEU A HD11 1 
ATOM   1554 H HD12 . LEU A 1 105 ? 34.85337 16.73529  11.85777  1.000 9.29570   ? 100 LEU A HD12 1 
ATOM   1555 H HD13 . LEU A 1 105 ? 34.85776 18.15502  12.57041  1.000 9.29570   ? 100 LEU A HD13 1 
ATOM   1556 H HD21 . LEU A 1 105 ? 33.96574 20.15524  11.35063  1.000 21.24694  ? 100 LEU A HD21 1 
ATOM   1557 H HD22 . LEU A 1 105 ? 33.40837 19.98552  9.87278   1.000 21.24694  ? 100 LEU A HD22 1 
ATOM   1558 H HD23 . LEU A 1 105 ? 32.59122 19.39864  11.10215  1.000 21.24694  ? 100 LEU A HD23 1 
ATOM   1559 N N    . GLY A 1 106 ? 37.68340 18.67225  7.27409   1.000 12.41811  ? 101 GLY A N    1 
ATOM   1560 C CA   . GLY A 1 106 ? 38.97289 19.20063  6.84592   1.000 16.69395  ? 101 GLY A CA   1 
ATOM   1561 C C    . GLY A 1 106 ? 38.89459 19.94271  5.53938   1.000 30.60550  ? 101 GLY A C    1 
ATOM   1562 O O    . GLY A 1 106 ? 39.72260 20.82654  5.27987   1.000 26.36083  ? 101 GLY A O    1 
ATOM   1563 H H    . GLY A 1 106 ? 37.53964 17.84787  7.07577   1.000 14.92414  ? 101 GLY A H    1 
ATOM   1564 H HA2  . GLY A 1 106 ? 39.30847 19.80975  7.52213   1.000 20.05514  ? 101 GLY A HA2  1 
ATOM   1565 H HA3  . GLY A 1 106 ? 39.59953 18.46750  6.74232   1.000 20.05514  ? 101 GLY A HA3  1 
ATOM   1566 N N    . LEU A 1 107 ? 37.90815 19.60825  4.69654   1.000 11.93803  ? 102 LEU A N    1 
ATOM   1567 C CA   . LEU A 1 107 ? 37.73492 20.28223  3.42137   1.000 18.57254  ? 102 LEU A CA   1 
ATOM   1568 C C    . LEU A 1 107 ? 37.16525 21.68076  3.62257   1.000 22.26420  ? 102 LEU A C    1 
ATOM   1569 O O    . LEU A 1 107 ? 37.41655 22.57108  2.80581   1.000 21.55673  ? 102 LEU A O    1 
ATOM   1570 C CB   . LEU A 1 107 ? 36.82934 19.44100  2.50712   1.000 16.55518  ? 102 LEU A CB   1 
ATOM   1571 C CG   . LEU A 1 107 ? 37.35878 18.08954  1.96317   1.000 32.55994  ? 102 LEU A CG   1 
ATOM   1572 C CD1  . LEU A 1 107 ? 36.28683 17.19406  1.26844   1.000 19.35717  ? 102 LEU A CD1  1 
ATOM   1573 C CD2  . LEU A 1 107 ? 38.53042 18.29678  0.97226   1.000 35.22333  ? 102 LEU A CD2  1 
ATOM   1574 H H    . LEU A 1 107 ? 37.32775 18.99161  4.84651   1.000 14.34803  ? 102 LEU A H    1 
ATOM   1575 H HA   . LEU A 1 107 ? 38.59252 20.37045  2.97680   1.000 22.30945  ? 102 LEU A HA   1 
ATOM   1576 H HB2  . LEU A 1 107 ? 36.02156 19.23881  3.00462   1.000 19.88861  ? 102 LEU A HB2  1 
ATOM   1577 H HB3  . LEU A 1 107 ? 36.61465 19.98334  1.73209   1.000 19.88861  ? 102 LEU A HB3  1 
ATOM   1578 H HG   . LEU A 1 107 ? 37.65682 17.61294  2.75369   1.000 39.09433  ? 102 LEU A HG   1 
ATOM   1579 H HD11 . LEU A 1 107 ? 36.62924 16.28931  1.19718   1.000 23.25101  ? 102 LEU A HD11 1 
ATOM   1580 H HD12 . LEU A 1 107 ? 35.47661 17.20005  1.80174   1.000 23.25101  ? 102 LEU A HD12 1 
ATOM   1581 H HD13 . LEU A 1 107 ? 36.10363 17.54899  0.38449   1.000 23.25101  ? 102 LEU A HD13 1 
ATOM   1582 H HD21 . LEU A 1 107 ? 38.81459 17.43316  0.63416   1.000 42.29040  ? 102 LEU A HD21 1 
ATOM   1583 H HD22 . LEU A 1 107 ? 38.22896 18.85606  0.23930   1.000 42.29040  ? 102 LEU A HD22 1 
ATOM   1584 H HD23 . LEU A 1 107 ? 39.26459 18.72792  1.43703   1.000 42.29040  ? 102 LEU A HD23 1 
ATOM   1585 N N    . LEU A 1 108 ? 36.38060 21.87787  4.68250   1.000 19.84426  ? 103 LEU A N    1 
ATOM   1586 C CA   . LEU A 1 108 ? 35.78822 23.18751  4.95207   1.000 24.36323  ? 103 LEU A CA   1 
ATOM   1587 C C    . LEU A 1 108 ? 36.79895 24.10550  5.58153   1.000 12.38232  ? 103 LEU A C    1 
ATOM   1588 O O    . LEU A 1 108 ? 36.88878 25.28178  5.22608   1.000 19.77240  ? 103 LEU A O    1 
ATOM   1589 C CB   . LEU A 1 108 ? 34.59012 23.06061  5.88746   1.000 24.47700  ? 103 LEU A CB   1 
ATOM   1590 C CG   . LEU A 1 108 ? 33.38318 22.25982  5.38148   1.000 26.97192  ? 103 LEU A CG   1 
ATOM   1591 C CD1  . LEU A 1 108 ? 32.80936 21.51733  6.54915   1.000 10.95262  ? 103 LEU A CD1  1 
ATOM   1592 C CD2  . LEU A 1 108 ? 32.27287 23.11685  4.63920   1.000 14.63673  ? 103 LEU A CD2  1 
ATOM   1593 H H    . LEU A 1 108 ? 36.17622 21.27293  5.25859   1.000 23.83552  ? 103 LEU A H    1 
ATOM   1594 H HA   . LEU A 1 108 ? 35.47870 23.56027  4.11174   1.000 29.25828  ? 103 LEU A HA   1 
ATOM   1595 H HB2  . LEU A 1 108 ? 34.89309 22.62885  6.70152   1.000 29.39480  ? 103 LEU A HB2  1 
ATOM   1596 H HB3  . LEU A 1 108 ? 34.27145 23.95518  6.08521   1.000 29.39480  ? 103 LEU A HB3  1 
ATOM   1597 H HG   . LEU A 1 108 ? 33.69068 21.64955  4.69306   1.000 32.38871  ? 103 LEU A HG   1 
ATOM   1598 H HD11 . LEU A 1 108 ? 32.66885 22.13889  7.28047   1.000 13.16554  ? 103 LEU A HD11 1 
ATOM   1599 H HD12 . LEU A 1 108 ? 31.96466 21.11952  6.28623   1.000 13.16554  ? 103 LEU A HD12 1 
ATOM   1600 H HD13 . LEU A 1 108 ? 33.43166 20.82401  6.81924   1.000 13.16554  ? 103 LEU A HD13 1 
ATOM   1601 H HD21 . LEU A 1 108 ? 31.71187 22.52242  4.11687   1.000 17.58648  ? 103 LEU A HD21 1 
ATOM   1602 H HD22 . LEU A 1 108 ? 31.73685 23.58066  5.30136   1.000 17.58648  ? 103 LEU A HD22 1 
ATOM   1603 H HD23 . LEU A 1 108 ? 32.70703 23.75913  4.05621   1.000 17.58648  ? 103 LEU A HD23 1 
ATOM   1604 N N    . ASP A 1 109 ? 37.59923 23.56232  6.48990   1.000 21.10647  ? 104 ASP A N    1 
ATOM   1605 C CA   . ASP A 1 109 ? 38.71030 24.31333  7.04145   1.000 15.56946  ? 104 ASP A CA   1 
ATOM   1606 C C    . ASP A 1 109 ? 39.81955 24.59146  6.03231   1.000 22.33929  ? 104 ASP A C    1 
ATOM   1607 O O    . ASP A 1 109 ? 40.69775 25.41462  6.32238   1.000 20.92555  ? 104 ASP A O    1 
ATOM   1608 C CB   . ASP A 1 109 ? 39.28756 23.56291  8.23346   1.000 28.94641  ? 104 ASP A CB   1 
ATOM   1609 C CG   . ASP A 1 109 ? 39.88311 24.48914  9.23500   1.000 42.98486  ? 104 ASP A CG   1 
ATOM   1610 O OD1  . ASP A 1 109 ? 39.18098 25.46457  9.60650   1.000 26.12154  ? 104 ASP A OD1  1 
ATOM   1611 O OD2  . ASP A 1 109 ? 41.04867 24.25821  9.61276   1.000 30.77363  ? 104 ASP A OD2  1 
ATOM   1612 H H    . ASP A 1 109 ? 37.51827 22.76432  6.80012   1.000 25.35016  ? 104 ASP A H    1 
ATOM   1613 H HA   . ASP A 1 109 ? 38.37613 25.17217  7.34413   1.000 18.70575  ? 104 ASP A HA   1 
ATOM   1614 H HB2  . ASP A 1 109 ? 38.58069 23.05994  8.66734   1.000 34.75809  ? 104 ASP A HB2  1 
ATOM   1615 H HB3  . ASP A 1 109 ? 39.98266 22.96039  7.92574   1.000 34.75809  ? 104 ASP A HB3  1 
ATOM   1616 N N    . SER A 1 110 ? 39.80185 23.96101  4.86108   1.000 21.23076  ? 105 SER A N    1 
ATOM   1617 C CA   . SER A 1 110 ? 40.94539 23.97942  3.96536   1.000 17.79131  ? 105 SER A CA   1 
ATOM   1618 C C    . SER A 1 110 ? 40.51325 23.85349  2.50409   1.000 13.90206  ? 105 SER A C    1 
ATOM   1619 O O    . SER A 1 110 ? 40.71606 22.84046  1.84270   1.000 18.63860  ? 105 SER A O    1 
ATOM   1620 C CB   . SER A 1 110 ? 41.90946 22.84869  4.35224   1.000 16.45788  ? 105 SER A CB   1 
ATOM   1621 O OG   . SER A 1 110 ? 42.76414 23.23662  5.41428   1.000 31.61461  ? 105 SER A OG   1 
ATOM   1622 H H    . SER A 1 110 ? 39.13059 23.51279  4.56424   1.000 25.49931  ? 105 SER A H    1 
ATOM   1623 H HA   . SER A 1 110 ? 41.37051 24.84863  4.03350   1.000 21.37197  ? 105 SER A HA   1 
ATOM   1624 H HB2  . SER A 1 110 ? 41.39176 22.07772  4.63238   1.000 19.77186  ? 105 SER A HB2  1 
ATOM   1625 H HB3  . SER A 1 110 ? 42.45173 22.62162  3.58069   1.000 19.77186  ? 105 SER A HB3  1 
ATOM   1626 H HG   . SER A 1 110 ? 43.47997 22.79829  5.38174   1.000 37.95993  ? 105 SER A HG   1 
ATOM   1627 N N    . HIS A 1 111 ? 39.95205 24.93131  1.93271   1.000 27.98213  ? 106 HIS A N    1 
ATOM   1628 C CA   . HIS A 1 111 ? 39.83286 26.30203  2.45987   1.000 16.22931  ? 106 HIS A CA   1 
ATOM   1629 C C    . HIS A 1 111 ? 38.45390 26.92800  2.10454   1.000 28.51706  ? 106 HIS A C    1 
ATOM   1630 O O    . HIS A 1 111 ? 38.35238 28.12456  1.85720   1.000 30.20887  ? 106 HIS A O    1 
ATOM   1631 C CB   . HIS A 1 111 ? 40.98621 27.17715  1.92455   1.000 16.60625  ? 106 HIS A CB   1 
ATOM   1632 C CG   . HIS A 1 111 ? 42.37188 26.62277  2.17966   1.000 33.20871  ? 106 HIS A CG   1 
ATOM   1633 N ND1  . HIS A 1 111 ? 43.13706 26.99387  3.26689   1.000 25.98016  ? 106 HIS A ND1  1 
ATOM   1634 C CD2  . HIS A 1 111 ? 43.14199 25.75918  1.46482   1.000 39.17172  ? 106 HIS A CD2  1 
ATOM   1635 C CE1  . HIS A 1 111 ? 44.31141 26.37501  3.21506   1.000 30.27351  ? 106 HIS A CE1  1 
ATOM   1636 N NE2  . HIS A 1 111 ? 44.34360 25.62282  2.12804   1.000 16.12126  ? 106 HIS A NE2  1 
ATOM   1637 H H    . HIS A 1 111 ? 39.59341 24.88882  1.15221   1.000 33.60096  ? 106 HIS A H    1 
ATOM   1638 H HA   . HIS A 1 111 ? 39.89666 26.28041  3.42752   1.000 19.49757  ? 106 HIS A HA   1 
ATOM   1639 H HB2  . HIS A 1 111 ? 40.88160 27.27165  0.96485   1.000 19.94991  ? 106 HIS A HB2  1 
ATOM   1640 H HB3  . HIS A 1 111 ? 40.93662 28.04701  2.35092   1.000 19.94991  ? 106 HIS A HB3  1 
ATOM   1641 H HD2  . HIS A 1 111 ? 42.90170 25.33682  0.67186   1.000 47.02846  ? 106 HIS A HD2  1 
ATOM   1642 H HE1  . HIS A 1 111 ? 44.99625 26.45706  3.83888   1.000 36.35061  ? 106 HIS A HE1  1 
ATOM   1643 H HE2  . HIS A 1 111 ? 45.00298 25.13118  1.87680   1.000 19.36791  ? 106 HIS A HE2  1 
ATOM   1644 N N    . LEU A 1 112 ? 37.38948 26.11457  2.19482   1.000 17.63787  ? 107 LEU A N    1 
ATOM   1645 C CA   . LEU A 1 112 ? 36.06296 26.47969  1.69155   1.000 18.66343  ? 107 LEU A CA   1 
ATOM   1646 C C    . LEU A 1 112 ? 35.40352 27.59977  2.49878   1.000 25.47043  ? 107 LEU A C    1 
ATOM   1647 O O    . LEU A 1 112 ? 34.83498 28.54588  1.92646   1.000 17.32918  ? 107 LEU A O    1 
ATOM   1648 C CB   . LEU A 1 112 ? 35.16957 25.23390  1.70119   1.000 14.86854  ? 107 LEU A CB   1 
ATOM   1649 C CG   . LEU A 1 112 ? 35.31668 24.26435  0.53806   1.000 20.60346  ? 107 LEU A CG   1 
ATOM   1650 C CD1  . LEU A 1 112 ? 34.56788 22.95856  0.77892   1.000 17.83660  ? 107 LEU A CD1  1 
ATOM   1651 C CD2  . LEU A 1 112 ? 34.80544 24.96211  -0.74081  1.000 31.86391  ? 107 LEU A CD2  1 
ATOM   1652 H H    . LEU A 1 112 ? 37.41201 25.33176  2.55020   1.000 21.18785  ? 107 LEU A H    1 
ATOM   1653 H HA   . LEU A 1 112 ? 36.16627 26.80966  0.78527   1.000 22.41852  ? 107 LEU A HA   1 
ATOM   1654 H HB2  . LEU A 1 112 ? 35.36284 24.73514  2.51038   1.000 17.86465  ? 107 LEU A HB2  1 
ATOM   1655 H HB3  . LEU A 1 112 ? 34.24586 25.52994  1.70659   1.000 17.86465  ? 107 LEU A HB3  1 
ATOM   1656 H HG   . LEU A 1 112 ? 36.25013 24.02173  0.43457   1.000 24.74655  ? 107 LEU A HG   1 
ATOM   1657 H HD11 . LEU A 1 112 ? 33.63476 23.15729  0.95411   1.000 21.42632  ? 107 LEU A HD11 1 
ATOM   1658 H HD12 . LEU A 1 112 ? 34.64459 22.40026  -0.01059  1.000 21.42632  ? 107 LEU A HD12 1 
ATOM   1659 H HD13 . LEU A 1 112 ? 34.95891 22.50657  1.54292   1.000 21.42632  ? 107 LEU A HD13 1 
ATOM   1660 H HD21 . LEU A 1 112 ? 34.70564 24.30053  -1.44313  1.000 38.25909  ? 107 LEU A HD21 1 
ATOM   1661 H HD22 . LEU A 1 112 ? 33.94902 25.37717  -0.55325  1.000 38.25909  ? 107 LEU A HD22 1 
ATOM   1662 H HD23 . LEU A 1 112 ? 35.44794 25.63679  -1.01080  1.000 38.25909  ? 107 LEU A HD23 1 
ATOM   1663 N N    . ILE A 1 113 ? 35.39786 27.48270  3.82854   1.000 13.71902  ? 108 ILE A N    1 
ATOM   1664 C CA   . ILE A 1 113 ? 34.76641 28.51479  4.65615   1.000 17.62405  ? 108 ILE A CA   1 
ATOM   1665 C C    . ILE A 1 113 ? 35.47121 29.87452  4.50985   1.000 25.67339  ? 108 ILE A C    1 
ATOM   1666 O O    . ILE A 1 113 ? 34.82061 30.92393  4.41653   1.000 20.45348  ? 108 ILE A O    1 
ATOM   1667 C CB   . ILE A 1 113 ? 34.72736 28.05355  6.12420   1.000 22.77319  ? 108 ILE A CB   1 
ATOM   1668 C CG1  . ILE A 1 113 ? 33.79815 26.85187  6.31019   1.000 14.60838  ? 108 ILE A CG1  1 
ATOM   1669 C CG2  . ILE A 1 113 ? 34.20921 29.16809  6.98758   1.000 17.50472  ? 108 ILE A CG2  1 
ATOM   1670 C CD1  . ILE A 1 113 ? 33.85478 26.20811  7.72638   1.000 20.89285  ? 108 ILE A CD1  1 
ATOM   1671 H H    . ILE A 1 113 ? 35.74486 26.83011  4.26821   1.000 16.48522  ? 108 ILE A H    1 
ATOM   1672 H HA   . ILE A 1 113 ? 33.85701 28.63467  4.34070   1.000 21.17126  ? 108 ILE A HA   1 
ATOM   1673 H HB   . ILE A 1 113 ? 35.63116 27.80341  6.37214   1.000 27.35023  ? 108 ILE A HB   1 
ATOM   1674 H HG12 . ILE A 1 113 ? 32.88498 27.14004  6.15534   1.000 17.55245  ? 108 ILE A HG12 1 
ATOM   1675 H HG13 . ILE A 1 113 ? 34.04389 26.16836  5.66729   1.000 17.55245  ? 108 ILE A HG13 1 
ATOM   1676 H HG21 . ILE A 1 113 ? 33.35828 29.47162  6.63448   1.000 21.02806  ? 108 ILE A HG21 1 
ATOM   1677 H HG22 . ILE A 1 113 ? 34.09327 28.83875  7.89256   1.000 21.02806  ? 108 ILE A HG22 1 
ATOM   1678 H HG23 . ILE A 1 113 ? 34.84927 29.89691  6.98027   1.000 21.02806  ? 108 ILE A HG23 1 
ATOM   1679 H HD11 . ILE A 1 113 ? 33.38515 26.78091  8.35267   1.000 25.09383  ? 108 ILE A HD11 1 
ATOM   1680 H HD12 . ILE A 1 113 ? 33.43123 25.33607  7.69403   1.000 25.09383  ? 108 ILE A HD12 1 
ATOM   1681 H HD13 . ILE A 1 113 ? 34.78243 26.11554  7.99433   1.000 25.09383  ? 108 ILE A HD13 1 
ATOM   1682 N N    . LYS A 1 114 ? 36.80646 29.89089  4.48669   1.000 19.48240  ? 109 LYS A N    1 
ATOM   1683 C CA   . LYS A 1 114 ? 37.47875 31.19117  4.46383   1.000 18.11849  ? 109 LYS A CA   1 
ATOM   1684 C C    . LYS A 1 114 ? 37.39828 31.91607  3.11705   1.000 29.49331  ? 109 LYS A C    1 
ATOM   1685 O O    . LYS A 1 114 ? 37.55467 33.14366  3.09120   1.000 23.45076  ? 109 LYS A O    1 
ATOM   1686 C CB   . LYS A 1 114 ? 38.93539 31.02344  4.87172   1.000 20.46088  ? 109 LYS A CB   1 
ATOM   1687 C CG   . LYS A 1 114 ? 39.82515 30.42978  3.81765   1.000 25.30153  ? 109 LYS A CG   1 
ATOM   1688 C CD   . LYS A 1 114 ? 41.30083 30.66990  4.18070   1.000 27.19882  ? 109 LYS A CD   1 
ATOM   1689 C CE   . LYS A 1 114 ? 41.76329 29.97895  5.45894   1.000 28.96375  ? 109 LYS A CE   1 
ATOM   1690 N NZ   . LYS A 1 114 ? 41.50707 28.52594  5.52741   1.000 32.61348  ? 109 LYS A NZ   1 
ATOM   1691 H H    . LYS A 1 114 ? 37.31875 29.20013  4.48385   1.000 23.40128  ? 109 LYS A H    1 
ATOM   1692 H HA   . LYS A 1 114 ? 37.03355 31.76151  5.10990   1.000 21.76459  ? 109 LYS A HA   1 
ATOM   1693 H HB2  . LYS A 1 114 ? 39.29361 31.89630  5.09686   1.000 24.57545  ? 109 LYS A HB2  1 
ATOM   1694 H HB3  . LYS A 1 114 ? 38.97221 30.44000  5.64576   1.000 24.57545  ? 109 LYS A HB3  1 
ATOM   1695 H HG2  . LYS A 1 114 ? 39.67039 29.47400  3.75910   1.000 30.38424  ? 109 LYS A HG2  1 
ATOM   1696 H HG3  . LYS A 1 114 ? 39.64291 30.84841  2.96183   1.000 30.38424  ? 109 LYS A HG3  1 
ATOM   1697 H HD2  . LYS A 1 114 ? 41.85486 30.34148  3.45538   1.000 32.66098  ? 109 LYS A HD2  1 
ATOM   1698 H HD3  . LYS A 1 114 ? 41.43896 31.62276  4.29844   1.000 32.66098  ? 109 LYS A HD3  1 
ATOM   1699 H HE2  . LYS A 1 114 ? 42.72096 30.10646  5.54564   1.000 34.77890  ? 109 LYS A HE2  1 
ATOM   1700 H HE3  . LYS A 1 114 ? 41.30489 30.38746  6.20987   1.000 34.77890  ? 109 LYS A HE3  1 
ATOM   1701 H HZ1  . LYS A 1 114 ? 41.65193 28.15350  4.73217   1.000 39.15858  ? 109 LYS A HZ1  1 
ATOM   1702 H HZ2  . LYS A 1 114 ? 40.66298 28.37664  5.76683   1.000 39.15858  ? 109 LYS A HZ2  1 
ATOM   1703 H HZ3  . LYS A 1 114 ? 42.04789 28.14933  6.12556   1.000 39.15858  ? 109 LYS A HZ3  1 
ATOM   1704 N N    A GLU A 1 115 ? 37.15955 31.22022  2.00810   0.394 16.63897  ? 110 GLU A N    1 
ATOM   1705 N N    B GLU A 1 115 ? 37.17031 31.18902  2.01760   0.606 16.15702  ? 110 GLU A N    1 
ATOM   1706 C CA   A GLU A 1 115 ? 37.05296 31.91290  0.72239   0.394 23.88881  ? 110 GLU A CA   1 
ATOM   1707 C CA   B GLU A 1 115 ? 37.05399 31.79266  0.68845   0.606 23.98318  ? 110 GLU A CA   1 
ATOM   1708 C C    A GLU A 1 115 ? 35.61144 32.25053  0.33258   0.394 20.71240  ? 110 GLU A C    1 
ATOM   1709 C C    B GLU A 1 115 ? 35.62792 32.24167  0.34290   0.606 20.41710  ? 110 GLU A C    1 
ATOM   1710 O O    A GLU A 1 115 ? 35.40668 32.92184  -0.68283  0.394 25.21663  ? 110 GLU A O    1 
ATOM   1711 O O    B GLU A 1 115 ? 35.45272 32.99234  -0.61949  0.606 25.22624  ? 110 GLU A O    1 
ATOM   1712 C CB   A GLU A 1 115 ? 37.69767 31.07757  -0.39361  0.394 23.46011  ? 110 GLU A CB   1 
ATOM   1713 C CB   B GLU A 1 115 ? 37.55487 30.79699  -0.38450  0.606 23.33597  ? 110 GLU A CB   1 
ATOM   1714 C CG   A GLU A 1 115 ? 39.23421 31.13845  -0.46338  0.394 21.54292  ? 110 GLU A CG   1 
ATOM   1715 C CG   B GLU A 1 115 ? 39.05844 30.90044  -0.73810  0.606 20.59437  ? 110 GLU A CG   1 
ATOM   1716 C CD   A GLU A 1 115 ? 39.80484 32.55604  -0.52866  0.394 19.05317  ? 110 GLU A CD   1 
ATOM   1717 C CD   B GLU A 1 115 ? 39.53140 29.90481  -1.81022  0.606 25.04393  ? 110 GLU A CD   1 
ATOM   1718 O OE1  A GLU A 1 115 ? 39.15701 33.46882  -1.08845  0.394 20.24959  ? 110 GLU A OE1  1 
ATOM   1719 O OE1  B GLU A 1 115 ? 38.79080 29.65585  -2.80353  0.606 23.50048  ? 110 GLU A OE1  1 
ATOM   1720 O OE2  A GLU A 1 115 ? 40.91938 32.75203  -0.00158  0.394 15.48816  ? 110 GLU A OE2  1 
ATOM   1721 O OE2  B GLU A 1 115 ? 40.67613 29.39847  -1.66333  0.606 15.30972  ? 110 GLU A OE2  1 
ATOM   1722 H H    A GLU A 1 115 ? 37.05777 30.36695  1.97382   0.394 19.98917  ? 110 GLU A H    1 
ATOM   1723 H H    B GLU A 1 115 ? 37.07838 30.33395  2.01708   0.606 19.41083  ? 110 GLU A H    1 
ATOM   1724 H HA   A GLU A 1 115 ? 37.54349 32.74677  0.79260   0.394 28.68897  ? 110 GLU A HA   1 
ATOM   1725 H HA   B GLU A 1 115 ? 37.61851 32.58085  0.65730   0.606 28.80222  ? 110 GLU A HA   1 
ATOM   1726 H HB2  A GLU A 1 115 ? 37.45130 30.14886  -0.26060  0.394 28.17453  ? 110 GLU A HB2  1 
ATOM   1727 H HB2  B GLU A 1 115 ? 37.39510 29.89590  -0.06292  0.606 28.02557  ? 110 GLU A HB2  1 
ATOM   1728 H HB3  A GLU A 1 115 ? 37.35730 31.39234  -1.24565  0.394 28.17453  ? 110 GLU A HB3  1 
ATOM   1729 H HB3  B GLU A 1 115 ? 37.05479 30.95133  -1.20120  0.606 28.02557  ? 110 GLU A HB3  1 
ATOM   1730 H HG2  A GLU A 1 115 ? 39.59789 30.71184  0.32822   0.394 25.87391  ? 110 GLU A HG2  1 
ATOM   1731 H HG2  B GLU A 1 115 ? 39.23748 31.79426  -1.06967  0.606 24.73565  ? 110 GLU A HG2  1 
ATOM   1732 H HG3  A GLU A 1 115 ? 39.52761 30.66705  -1.25874  0.394 25.87391  ? 110 GLU A HG3  1 
ATOM   1733 H HG3  B GLU A 1 115 ? 39.57714 30.73426  0.06454   0.606 24.73565  ? 110 GLU A HG3  1 
ATOM   1734 N N    . ALA A 1 116 ? 34.61415 31.82642  1.11172   1.000 19.32062  ? 111 ALA A N    1 
ATOM   1735 C CA   . ALA A 1 116 ? 33.20738 32.04751  0.76362   1.000 31.13905  ? 111 ALA A CA   1 
ATOM   1736 C C    . ALA A 1 116 ? 32.67509 33.34423  1.36256   1.000 26.23438  ? 111 ALA A C    1 
ATOM   1737 O O    . ALA A 1 116 ? 32.52669 33.44529  2.57887   1.000 20.45811  ? 111 ALA A O    1 
ATOM   1738 C CB   . ALA A 1 116 ? 32.33847 30.88928  1.23864   1.000 24.63821  ? 111 ALA A CB   1 
ATOM   1739 H H    A ALA A 1 116 ? 34.72721 31.40492  1.85277   0.394 23.20714  ? 111 ALA A H    1 
ATOM   1740 H H    B ALA A 1 116 ? 34.71914 31.40598  1.85455   0.606 23.20714  ? 111 ALA A H    1 
ATOM   1741 H HA   . ALA A 1 116 ? 33.17467 32.12643  -0.20261  1.000 37.38926  ? 111 ALA A HA   1 
ATOM   1742 H HB1  . ALA A 1 116 ? 32.42071 30.80704  2.20165   1.000 29.58825  ? 111 ALA A HB1  1 
ATOM   1743 H HB2  . ALA A 1 116 ? 31.41556 31.06811  0.99956   1.000 29.58825  ? 111 ALA A HB2  1 
ATOM   1744 H HB3  . ALA A 1 116 ? 32.63892 30.07262  0.81006   1.000 29.58825  ? 111 ALA A HB3  1 
ATOM   1745 N N    . GLY A 1 117 ? 32.31695 34.30372  0.49570   1.000 33.76657  ? 112 GLY A N    1 
ATOM   1746 C CA   . GLY A 1 117 ? 31.88677 35.63149  0.90726   1.000 32.76739  ? 112 GLY A CA   1 
ATOM   1747 C C    . GLY A 1 117 ? 30.41355 35.94708  0.71468   1.000 39.28299  ? 112 GLY A C    1 
ATOM   1748 O O    . GLY A 1 117 ? 29.90372 36.92983  1.26577   1.000 40.71597  ? 112 GLY A O    1 
ATOM   1749 H H    . GLY A 1 117 ? 32.31719 34.20000  -0.35802  1.000 40.54228  ? 112 GLY A H    1 
ATOM   1750 H HA2  . GLY A 1 117 ? 32.08508 35.73880  1.85069   1.000 39.34327  ? 112 GLY A HA2  1 
ATOM   1751 H HA3  . GLY A 1 117 ? 32.39199 36.28734  0.40177   1.000 39.34327  ? 112 GLY A HA3  1 
ATOM   1752 N N    . ASP A 1 118 ? 29.71453 35.13537  -0.06826  1.000 25.84611  ? 113 ASP A N    1 
ATOM   1753 C CA   . ASP A 1 118 ? 28.28796 35.30920  -0.23903  1.000 21.41103  ? 113 ASP A CA   1 
ATOM   1754 C C    . ASP A 1 118 ? 27.56782 34.72834  0.97188   1.000 31.09504  ? 113 ASP A C    1 
ATOM   1755 O O    . ASP A 1 118 ? 28.05816 33.80796  1.62517   1.000 22.35426  ? 113 ASP A O    1 
ATOM   1756 C CB   . ASP A 1 118 ? 27.81181 34.61869  -1.50844  1.000 26.69210  ? 113 ASP A CB   1 
ATOM   1757 C CG   . ASP A 1 118 ? 28.00531 35.46608  -2.73355  1.000 31.04391  ? 113 ASP A CG   1 
ATOM   1758 O OD1  . ASP A 1 118 ? 28.20276 36.68529  -2.59386  1.000 28.05440  ? 113 ASP A OD1  1 
ATOM   1759 O OD2  . ASP A 1 118 ? 27.95411 34.90867  -3.84742  1.000 33.72751  ? 113 ASP A OD2  1 
ATOM   1760 H H    . ASP A 1 118 ? 30.04725 34.47690  -0.51021  1.000 31.03773  ? 113 ASP A H    1 
ATOM   1761 H HA   . ASP A 1 118 ? 28.06915 36.25068  -0.32054  1.000 25.71564  ? 113 ASP A HA   1 
ATOM   1762 H HB2  . ASP A 1 118 ? 28.31291 33.79695  -1.62905  1.000 32.05292  ? 113 ASP A HB2  1 
ATOM   1763 H HB3  . ASP A 1 118 ? 26.86572 34.42125  -1.42581  1.000 32.05292  ? 113 ASP A HB3  1 
ATOM   1764 N N    . ALA A 1 119 ? 26.38017 35.25321  1.25499   1.000 16.27680  ? 114 ALA A N    1 
ATOM   1765 C CA   . ALA A 1 119 ? 25.63276 34.75445  2.40398   1.000 24.56346  ? 114 ALA A CA   1 
ATOM   1766 C C    . ALA A 1 119 ? 25.27198 33.28410  2.23857   1.000 23.45402  ? 114 ALA A C    1 
ATOM   1767 O O    . ALA A 1 119 ? 25.30802 32.51866  3.20818   1.000 24.10346  ? 114 ALA A O    1 
ATOM   1768 C CB   . ALA A 1 119 ? 24.37137 35.59198  2.61507   1.000 26.87661  ? 114 ALA A CB   1 
ATOM   1769 H H    . ALA A 1 119 ? 25.99482 35.88100  0.81116   1.000 19.55457  ? 114 ALA A H    1 
ATOM   1770 H HA   . ALA A 1 119 ? 26.18896 34.83986  3.19407   1.000 29.49855  ? 114 ALA A HA   1 
ATOM   1771 H HB1  . ALA A 1 119 ? 23.86749 35.22253  3.35703   1.000 32.27433  ? 114 ALA A HB1  1 
ATOM   1772 H HB2  . ALA A 1 119 ? 24.62866 36.50614  2.81255   1.000 32.27433  ? 114 ALA A HB2  1 
ATOM   1773 H HB3  . ALA A 1 119 ? 23.83625 35.56629  1.80643   1.000 32.27433  ? 114 ALA A HB3  1 
ATOM   1774 N N    . GLU A 1 120 ? 24.94757 32.86280  1.01421   1.000 25.37547  ? 115 GLU A N    1 
ATOM   1775 C CA   . GLU A 1 120 ? 24.35363 31.54629  0.78926   1.000 26.94860  ? 115 GLU A CA   1 
ATOM   1776 C C    . GLU A 1 120 ? 25.40686 30.45531  0.70543   1.000 25.44374  ? 115 GLU A C    1 
ATOM   1777 O O    . GLU A 1 120 ? 25.14632 29.29980  1.06328   1.000 29.65922  ? 115 GLU A O    1 
ATOM   1778 C CB   . GLU A 1 120 ? 23.51428 31.57860  -0.48752  1.000 31.62780  ? 115 GLU A CB   1 
ATOM   1779 C CG   . GLU A 1 120 ? 22.35285 32.55008  -0.37446  1.000 53.14675  ? 115 GLU A CG   1 
ATOM   1780 C CD   . GLU A 1 120 ? 21.09681 32.08421  -1.07613  1.000 60.02367  ? 115 GLU A CD   1 
ATOM   1781 O OE1  . GLU A 1 120 ? 20.79957 30.86433  -1.08038  1.000 51.00258  ? 115 GLU A OE1  1 
ATOM   1782 O OE2  . GLU A 1 120 ? 20.38568 32.96234  -1.60035  1.000 83.48913  ? 115 GLU A OE2  1 
ATOM   1783 H H    . GLU A 1 120 ? 25.06166 33.32161  0.29582   1.000 30.47296  ? 115 GLU A H    1 
ATOM   1784 H HA   . GLU A 1 120 ? 23.76659 31.32762  1.52985   1.000 32.36073  ? 115 GLU A HA   1 
ATOM   1785 H HB2  . GLU A 1 120 ? 24.07294 31.85711  -1.22997  1.000 37.97576  ? 115 GLU A HB2  1 
ATOM   1786 H HB3  . GLU A 1 120 ? 23.15538 30.69337  -0.65621  1.000 37.97576  ? 115 GLU A HB3  1 
ATOM   1787 H HG2  . GLU A 1 120 ? 22.13897 32.67293  0.56365   1.000 63.79851  ? 115 GLU A HG2  1 
ATOM   1788 H HG3  . GLU A 1 120 ? 22.61476 33.39679  -0.76866  1.000 63.79851  ? 115 GLU A HG3  1 
ATOM   1789 N N    . SER A 1 121 ? 26.58191 30.81459  0.20756   1.000 22.57685  ? 116 SER A N    1 
ATOM   1790 C CA   . SER A 1 121 ? 27.75170 29.96226  0.32604   1.000 22.93399  ? 116 SER A CA   1 
ATOM   1791 C C    . SER A 1 121 ? 28.14072 29.76312  1.78374   1.000 20.44333  ? 116 SER A C    1 
ATOM   1792 O O    . SER A 1 121 ? 28.27019 28.63036  2.25364   1.000 12.40991  ? 116 SER A O    1 
ATOM   1793 C CB   . SER A 1 121 ? 28.90542 30.60456  -0.44068  1.000 8.88347   ? 116 SER A CB   1 
ATOM   1794 O OG   . SER A 1 121 ? 28.46064 31.20095  -1.65042  1.000 38.17126  ? 116 SER A OG   1 
ATOM   1795 H H    . SER A 1 121 ? 26.72944 31.55346  -0.20705  1.000 27.11462  ? 116 SER A H    1 
ATOM   1796 H HA   . SER A 1 121 ? 27.55616 29.09155  -0.05414  1.000 27.54319  ? 116 SER A HA   1 
ATOM   1797 H HB2  . SER A 1 121 ? 29.30822 31.28922  0.11601   1.000 10.68256  ? 116 SER A HB2  1 
ATOM   1798 H HB3  . SER A 1 121 ? 29.56020 29.92061  -0.65134  1.000 10.68256  ? 116 SER A HB3  1 
ATOM   1799 H HG   . SER A 1 121 ? 28.17864 30.60923  -2.17573  1.000 45.82792  ? 116 SER A HG   1 
ATOM   1800 N N    A ARG A 1 122 ? 28.31999 30.86567  2.51695   0.196 17.89128  ? 117 ARG A N    1 
ATOM   1801 N N    B ARG A 1 122 ? 28.27540 30.86771  2.52427   0.804 18.60047  ? 117 ARG A N    1 
ATOM   1802 C CA   A ARG A 1 122 ? 28.91422 30.81498  3.84774   0.196 20.15190  ? 117 ARG A CA   1 
ATOM   1803 C CA   B ARG A 1 122 ? 28.89013 30.86408  3.84490   0.804 20.06838  ? 117 ARG A CA   1 
ATOM   1804 C C    A ARG A 1 122 ? 27.98081 30.16545  4.85850   0.196 16.50168  ? 117 ARG A C    1 
ATOM   1805 C C    B ARG A 1 122 ? 27.98895 30.23332  4.88928   0.804 16.40373  ? 117 ARG A C    1 
ATOM   1806 O O    A ARG A 1 122 ? 28.42798 29.41751  5.73616   0.196 19.96175  ? 117 ARG A O    1 
ATOM   1807 O O    B ARG A 1 122 ? 28.46424 29.56388  5.81590   0.804 19.83649  ? 117 ARG A O    1 
ATOM   1808 C CB   A ARG A 1 122 ? 29.28024 32.23261  4.28640   0.196 20.39593  ? 117 ARG A CB   1 
ATOM   1809 C CB   B ARG A 1 122 ? 29.22465 32.30552  4.22119   0.804 19.93267  ? 117 ARG A CB   1 
ATOM   1810 C CG   A ARG A 1 122 ? 29.91841 32.31530  5.65346   0.196 33.55685  ? 117 ARG A CG   1 
ATOM   1811 C CG   B ARG A 1 122 ? 29.82405 32.46116  5.58601   0.804 34.37320  ? 117 ARG A CG   1 
ATOM   1812 C CD   A ARG A 1 122 ? 30.74695 33.58669  5.82196   0.196 37.74543  ? 117 ARG A CD   1 
ATOM   1813 C CD   B ARG A 1 122 ? 30.73734 33.69525  5.70479   0.804 38.41332  ? 117 ARG A CD   1 
ATOM   1814 N NE   A ARG A 1 122 ? 31.76562 33.42881  6.85451   0.196 33.70406  ? 117 ARG A NE   1 
ATOM   1815 N NE   B ARG A 1 122 ? 31.71174 33.50643  6.77601   0.804 33.71686  ? 117 ARG A NE   1 
ATOM   1816 C CZ   A ARG A 1 122 ? 33.02133 33.06703  6.62530   0.196 35.62138  ? 117 ARG A CZ   1 
ATOM   1817 C CZ   B ARG A 1 122 ? 32.96536 33.11935  6.59112   0.804 35.55509  ? 117 ARG A CZ   1 
ATOM   1818 N NH1  A ARG A 1 122 ? 33.45587 32.81090  5.40283   0.196 30.93441  ? 117 ARG A NH1  1 
ATOM   1819 N NH1  B ARG A 1 122 ? 33.44037 32.87319  5.38500   0.804 30.90718  ? 117 ARG A NH1  1 
ATOM   1820 N NH2  A ARG A 1 122 ? 33.86298 32.96261  7.64972   0.196 48.34368  ? 117 ARG A NH2  1 
ATOM   1821 N NH2  B ARG A 1 122 ? 33.76548 32.98650  7.64587   0.804 48.85014  ? 117 ARG A NH2  1 
ATOM   1822 H H    A ARG A 1 122 ? 28.10409 31.65854  2.26327   0.196 21.49194  ? 117 ARG A H    1 
ATOM   1823 H H    B ARG A 1 122 ? 28.01202 31.64792  2.27627   0.804 22.34297  ? 117 ARG A H    1 
ATOM   1824 H HA   A ARG A 1 122 ? 29.72176 30.27862  3.81439   0.196 24.20468  ? 117 ARG A HA   1 
ATOM   1825 H HA   B ARG A 1 122 ? 29.70493 30.33826  3.82185   0.804 24.10445  ? 117 ARG A HA   1 
ATOM   1826 H HB2  A ARG A 1 122 ? 29.90813 32.60247  3.64619   0.196 24.49752  ? 117 ARG A HB2  1 
ATOM   1827 H HB2  B ARG A 1 122 ? 29.86219 32.65377  3.57841   0.804 23.94161  ? 117 ARG A HB2  1 
ATOM   1828 H HB3  A ARG A 1 122 ? 28.47223 32.76891  4.30642   0.196 24.49752  ? 117 ARG A HB3  1 
ATOM   1829 H HB3  B ARG A 1 122 ? 28.40883 32.82966  4.19664   0.804 23.94161  ? 117 ARG A HB3  1 
ATOM   1830 H HG2  A ARG A 1 122 ? 29.22397 32.31454  6.33070   0.196 40.29062  ? 117 ARG A HG2  1 
ATOM   1831 H HG2  B ARG A 1 122 ? 29.10977 32.55477  6.23558   0.804 41.27024  ? 117 ARG A HG2  1 
ATOM   1832 H HG3  A ARG A 1 122 ? 30.50489 31.55292  5.77881   0.196 40.29062  ? 117 ARG A HG3  1 
ATOM   1833 H HG3  B ARG A 1 122 ? 30.35585 31.67563  5.78858   0.804 41.27024  ? 117 ARG A HG3  1 
ATOM   1834 H HD2  A ARG A 1 122 ? 31.19087 33.79386  4.98475   0.196 45.31692  ? 117 ARG A HD2  1 
ATOM   1835 H HD2  B ARG A 1 122 ? 31.21534 33.82758  4.87118   0.804 46.11839  ? 117 ARG A HD2  1 
ATOM   1836 H HD3  A ARG A 1 122 ? 30.16382 34.31826  6.07817   0.196 45.31692  ? 117 ARG A HD3  1 
ATOM   1837 H HD3  B ARG A 1 122 ? 30.20164 34.47799  5.90791   0.804 46.11839  ? 117 ARG A HD3  1 
ATOM   1838 H HE   A ARG A 1 122 ? 31.53589 33.58101  7.66917   0.196 40.46727  ? 117 ARG A HE   1 
ATOM   1839 H HE   B ARG A 1 122 ? 31.45407 33.65686  7.58259   0.804 40.48263  ? 117 ARG A HE   1 
ATOM   1840 H HH11 A ARG A 1 122 ? 32.92020 32.87736  4.73332   0.196 37.14369  ? 117 ARG A HH11 1 
ATOM   1841 H HH11 B ARG A 1 122 ? 32.93299 32.96300  4.69644   0.804 37.11102  ? 117 ARG A HH11 1 
ATOM   1842 H HH12 A ARG A 1 122 ? 34.27414 32.57789  5.27735   0.196 37.14369  ? 117 ARG A HH12 1 
ATOM   1843 H HH12 B ARG A 1 122 ? 34.25735 32.62295  5.28742   0.804 37.11102  ? 117 ARG A HH12 1 
ATOM   1844 H HH21 A ARG A 1 122 ? 33.59089 33.12880  8.44844   0.196 58.03482  ? 117 ARG A HH21 1 
ATOM   1845 H HH21 B ARG A 1 122 ? 33.46706 33.15124  8.43543   0.804 58.64257  ? 117 ARG A HH21 1 
ATOM   1846 H HH22 A ARG A 1 122 ? 34.67932 32.72891  7.51345   0.196 58.03482  ? 117 ARG A HH22 1 
ATOM   1847 H HH22 B ARG A 1 122 ? 34.58106 32.73589  7.53805   0.804 58.64257  ? 117 ARG A HH22 1 
ATOM   1848 N N    . VAL A 1 123 ? 26.68350 30.45310  4.76363   1.000 16.94003  ? 118 VAL A N    1 
ATOM   1849 C CA   . VAL A 1 123 ? 25.70699 29.82763  5.64429   1.000 5.49681   ? 118 VAL A CA   1 
ATOM   1850 C C    . VAL A 1 123 ? 25.58733 28.32797  5.35231   1.000 15.35098  ? 118 VAL A C    1 
ATOM   1851 O O    . VAL A 1 123 ? 25.35046 27.53273  6.27257   1.000 9.21549   ? 118 VAL A O    1 
ATOM   1852 C CB   . VAL A 1 123 ? 24.37802 30.60005  5.44844   1.000 19.79380  ? 118 VAL A CB   1 
ATOM   1853 C CG1  . VAL A 1 123 ? 23.15112 29.81083  5.87511   1.000 17.93155  ? 118 VAL A CG1  1 
ATOM   1854 C CG2  . VAL A 1 123 ? 24.40590 31.97553  6.17335   1.000 15.41443  ? 118 VAL A CG2  1 
ATOM   1855 H H    A VAL A 1 123 ? 26.34512 31.00602  4.19849   0.196 20.35043  ? 118 VAL A H    1 
ATOM   1856 H H    B VAL A 1 123 ? 26.33320 30.96647  4.16921   0.804 20.35043  ? 118 VAL A H    1 
ATOM   1857 H HA   . VAL A 1 123 ? 25.97798 29.88424  6.57395   1.000 6.61857   ? 118 VAL A HA   1 
ATOM   1858 H HB   . VAL A 1 123 ? 24.29694 30.74929  4.49342   1.000 23.77496  ? 118 VAL A HB   1 
ATOM   1859 H HG11 . VAL A 1 123 ? 23.02452 29.06874  5.26341   1.000 21.54026  ? 118 VAL A HG11 1 
ATOM   1860 H HG12 . VAL A 1 123 ? 23.28752 29.47751  6.77577   1.000 21.54026  ? 118 VAL A HG12 1 
ATOM   1861 H HG13 . VAL A 1 123 ? 22.37656 30.39430  5.85210   1.000 21.54026  ? 118 VAL A HG13 1 
ATOM   1862 H HG21 . VAL A 1 123 ? 23.65593 32.50911  5.86718   1.000 18.51971  ? 118 VAL A HG21 1 
ATOM   1863 H HG22 . VAL A 1 123 ? 24.33943 31.82972  7.13002   1.000 18.51971  ? 118 VAL A HG22 1 
ATOM   1864 H HG23 . VAL A 1 123 ? 25.23931 32.42574  5.96448   1.000 18.51971  ? 118 VAL A HG23 1 
ATOM   1865 N N    . PHE A 1 124 ? 25.72727 27.91594  4.07325   1.000 25.17942  ? 119 PHE A N    1 
ATOM   1866 C CA   . PHE A 1 124 ? 25.66650 26.49595  3.70310   1.000 16.13278  ? 119 PHE A CA   1 
ATOM   1867 C C    . PHE A 1 124 ? 26.83159 25.71637  4.31349   1.000 19.76964  ? 119 PHE A C    1 
ATOM   1868 O O    . PHE A 1 124 ? 26.61746 24.63000  4.86213   1.000 20.25902  ? 119 PHE A O    1 
ATOM   1869 C CB   . PHE A 1 124 ? 25.66086 26.36312  2.17324   1.000 14.81358  ? 119 PHE A CB   1 
ATOM   1870 C CG   . PHE A 1 124 ? 25.62442 24.94079  1.65259   1.000 11.41541  ? 119 PHE A CG   1 
ATOM   1871 C CD1  . PHE A 1 124 ? 26.78781 24.18115  1.56598   1.000 22.49258  ? 119 PHE A CD1  1 
ATOM   1872 C CD2  . PHE A 1 124 ? 24.44713 24.39436  1.17148   1.000 12.15543  ? 119 PHE A CD2  1 
ATOM   1873 C CE1  . PHE A 1 124 ? 26.75720 22.89374  1.05953   1.000 17.50636  ? 119 PHE A CE1  1 
ATOM   1874 C CE2  . PHE A 1 124 ? 24.41305 23.10259  0.66570   1.000 20.44938  ? 119 PHE A CE2  1 
ATOM   1875 C CZ   . PHE A 1 124 ? 25.56844 22.35337  0.61530   1.000 15.58937  ? 119 PHE A CZ   1 
ATOM   1876 H H    . PHE A 1 124 ? 25.85801 28.44190  3.40552   1.000 30.23771  ? 119 PHE A H    1 
ATOM   1877 H HA   . PHE A 1 124 ? 24.84361 26.11091  4.04297   1.000 19.38173  ? 119 PHE A HA   1 
ATOM   1878 H HB2  . PHE A 1 124 ? 24.87694 26.81875  1.82861   1.000 17.79870  ? 119 PHE A HB2  1 
ATOM   1879 H HB3  . PHE A 1 124 ? 26.46559 26.77892  1.82622   1.000 17.79870  ? 119 PHE A HB3  1 
ATOM   1880 H HD1  . PHE A 1 124 ? 27.59528 24.54327  1.85194   1.000 27.01350  ? 119 PHE A HD1  1 
ATOM   1881 H HD2  . PHE A 1 124 ? 23.66717 24.90063  1.18745   1.000 14.60892  ? 119 PHE A HD2  1 
ATOM   1882 H HE1  . PHE A 1 124 ? 27.53926 22.39213  1.01862   1.000 21.03003  ? 119 PHE A HE1  1 
ATOM   1883 H HE2  . PHE A 1 124 ? 23.61133 22.74292  0.36110   1.000 24.56166  ? 119 PHE A HE2  1 
ATOM   1884 H HZ   . PHE A 1 124 ? 25.54674 21.48524  0.28248   1.000 18.72965  ? 119 PHE A HZ   1 
ATOM   1885 N N    . TYR A 1 125 ? 28.06869 26.27194  4.25802   1.000 12.20285  ? 120 TYR A N    1 
ATOM   1886 C CA   . TYR A 1 125 ? 29.21203 25.56076  4.81491   1.000 2.85684   ? 120 TYR A CA   1 
ATOM   1887 C C    . TYR A 1 125 ? 29.19070 25.53987  6.33897   1.000 13.00489  ? 120 TYR A C    1 
ATOM   1888 O O    . TYR A 1 125 ? 29.67275 24.57199  6.93308   1.000 28.40017  ? 120 TYR A O    1 
ATOM   1889 C CB   . TYR A 1 125 ? 30.55313 26.14908  4.32606   1.000 11.74406  ? 120 TYR A CB   1 
ATOM   1890 C CG   . TYR A 1 125 ? 30.83151 26.02068  2.82453   1.000 21.36418  ? 120 TYR A CG   1 
ATOM   1891 C CD1  . TYR A 1 125 ? 30.67832 24.81095  2.15320   1.000 13.53720  ? 120 TYR A CD1  1 
ATOM   1892 C CD2  . TYR A 1 125 ? 31.22559 27.13090  2.07691   1.000 11.38132  ? 120 TYR A CD2  1 
ATOM   1893 C CE1  . TYR A 1 125 ? 30.89192 24.72026  0.76668   1.000 19.97538  ? 120 TYR A CE1  1 
ATOM   1894 C CE2  . TYR A 1 125 ? 31.43999 27.04765  0.71846   1.000 18.49843  ? 120 TYR A CE2  1 
ATOM   1895 C CZ   . TYR A 1 125 ? 31.27566 25.84598  0.06708   1.000 20.18570  ? 120 TYR A CZ   1 
ATOM   1896 O OH   . TYR A 1 125 ? 31.50913 25.77570  -1.28963  1.000 15.05803  ? 120 TYR A OH   1 
ATOM   1897 H H    . TYR A 1 125 ? 28.25239 27.03699  3.91082   1.000 14.66582  ? 120 TYR A H    1 
ATOM   1898 H HA   . TYR A 1 125 ? 29.15925 24.64887  4.48846   1.000 3.45060   ? 120 TYR A HA   1 
ATOM   1899 H HB2  . TYR A 1 125 ? 30.56598 27.09498  4.54055   1.000 14.11527  ? 120 TYR A HB2  1 
ATOM   1900 H HB3  . TYR A 1 125 ? 31.27215 25.69360  4.79131   1.000 14.11527  ? 120 TYR A HB3  1 
ATOM   1901 H HD1  . TYR A 1 125 ? 30.43092 24.05121  2.62911   1.000 16.26705  ? 120 TYR A HD1  1 
ATOM   1902 H HD2  . TYR A 1 125 ? 31.34651 27.94706  2.50605   1.000 13.67998  ? 120 TYR A HD2  1 
ATOM   1903 H HE1  . TYR A 1 125 ? 30.77577 23.90986  0.32548   1.000 23.99286  ? 120 TYR A HE1  1 
ATOM   1904 H HE2  . TYR A 1 125 ? 31.69588 27.80372  0.24121   1.000 22.22052  ? 120 TYR A HE2  1 
ATOM   1905 H HH   . TYR A 1 125 ? 31.75315 26.52581  -1.57839  1.000 18.09204  ? 120 TYR A HH   1 
ATOM   1906 N N    . LEU A 1 126 ? 28.63766 26.57313  7.00165   1.000 20.73107  ? 121 LEU A N    1 
ATOM   1907 C CA   . LEU A 1 126 ? 28.68590 26.59496  8.46773   1.000 14.06792  ? 121 LEU A CA   1 
ATOM   1908 C C    . LEU A 1 126 ? 27.65977 25.63070  9.07114   1.000 20.07366  ? 121 LEU A C    1 
ATOM   1909 O O    . LEU A 1 126 ? 27.93518 25.00511  10.09941  1.000 14.68250  ? 121 LEU A O    1 
ATOM   1910 C CB   . LEU A 1 126 ? 28.47026 28.01392  9.01411   1.000 6.99249   ? 121 LEU A CB   1 
ATOM   1911 C CG   . LEU A 1 126 ? 29.54542 29.08378  8.92108   1.000 29.64676  ? 121 LEU A CG   1 
ATOM   1912 C CD1  . LEU A 1 126 ? 28.88524 30.39836  9.35467   1.000 26.75153  ? 121 LEU A CD1  1 
ATOM   1913 C CD2  . LEU A 1 126 ? 30.74363 28.74196  9.77764   1.000 18.09710  ? 121 LEU A CD2  1 
ATOM   1914 H H    . LEU A 1 126 ? 28.24493 27.24552  6.63660   1.000 24.89968  ? 121 LEU A H    1 
ATOM   1915 H HA   . LEU A 1 126 ? 29.57364 26.31734  8.74292   1.000 16.90390  ? 121 LEU A HA   1 
ATOM   1916 H HB2  . LEU A 1 126 ? 27.69977 28.37713  8.55006   1.000 8.41339   ? 121 LEU A HB2  1 
ATOM   1917 H HB3  . LEU A 1 126 ? 28.27491 27.92172  9.95975   1.000 8.41339   ? 121 LEU A HB3  1 
ATOM   1918 H HG   . LEU A 1 126 ? 29.89449 29.16304  8.01954   1.000 35.59852  ? 121 LEU A HG   1 
ATOM   1919 H HD11 . LEU A 1 126 ? 28.49103 30.27914  10.23290  1.000 32.12424  ? 121 LEU A HD11 1 
ATOM   1920 H HD12 . LEU A 1 126 ? 29.55956 31.09490  9.38657   1.000 32.12424  ? 121 LEU A HD12 1 
ATOM   1921 H HD13 . LEU A 1 126 ? 28.19730 30.63313  8.71240   1.000 32.12424  ? 121 LEU A HD13 1 
ATOM   1922 H HD21 . LEU A 1 126 ? 31.36294 29.48843  9.76666   1.000 21.73892  ? 121 LEU A HD21 1 
ATOM   1923 H HD22 . LEU A 1 126 ? 30.44528 28.57300  10.68502  1.000 21.73892  ? 121 LEU A HD22 1 
ATOM   1924 H HD23 . LEU A 1 126 ? 31.17343 27.95026  9.41793   1.000 21.73892  ? 121 LEU A HD23 1 
ATOM   1925 N N    . LYS A 1 127 ? 26.47391 25.51294  8.44783   1.000 11.68114  ? 122 LYS A N    1 
ATOM   1926 C CA   . LYS A 1 127 ? 25.53506 24.43371  8.76621   1.000 13.66636  ? 122 LYS A CA   1 
ATOM   1927 C C    . LYS A 1 127 ? 26.19997 23.05315  8.71133   1.000 17.04670  ? 122 LYS A C    1 
ATOM   1928 O O    . LYS A 1 127 ? 26.14555 22.28145  9.66931   1.000 16.56996  ? 122 LYS A O    1 
ATOM   1929 C CB   . LYS A 1 127 ? 24.33152 24.47015  7.80048   1.000 9.83795   ? 122 LYS A CB   1 
ATOM   1930 C CG   . LYS A 1 127 ? 23.30247 23.28376  7.92834   1.000 7.65069   ? 122 LYS A CG   1 
ATOM   1931 C CD   . LYS A 1 127 ? 22.11449 23.40340  6.93229   1.000 9.03187   ? 122 LYS A CD   1 
ATOM   1932 C CE   . LYS A 1 127 ? 21.26984 22.10048  6.84933   1.000 9.48947   ? 122 LYS A CE   1 
ATOM   1933 N NZ   . LYS A 1 127 ? 21.99058 20.95528  6.21569   1.000 15.85658  ? 122 LYS A NZ   1 
ATOM   1934 H H    . LYS A 1 127 ? 26.19247 26.04808  7.83626   1.000 14.03977  ? 122 LYS A H    1 
ATOM   1935 H HA   . LYS A 1 127 ? 25.21825 24.58185  9.67097   1.000 16.42203  ? 122 LYS A HA   1 
ATOM   1936 H HB2  . LYS A 1 127 ? 23.84136 25.29206  7.95891   1.000 11.82794  ? 122 LYS A HB2  1 
ATOM   1937 H HB3  . LYS A 1 127 ? 24.67194 24.45669  6.89228   1.000 11.82794  ? 122 LYS A HB3  1 
ATOM   1938 H HG2  . LYS A 1 127 ? 23.76024 22.44767  7.74859   1.000 9.20323   ? 122 LYS A HG2  1 
ATOM   1939 H HG3  . LYS A 1 127 ? 22.93898 23.27630  8.82763   1.000 9.20323   ? 122 LYS A HG3  1 
ATOM   1940 H HD2  . LYS A 1 127 ? 21.53019 24.12197  7.22063   1.000 10.86065  ? 122 LYS A HD2  1 
ATOM   1941 H HD3  . LYS A 1 127 ? 22.46136 23.59306  6.04650   1.000 10.86065  ? 122 LYS A HD3  1 
ATOM   1942 H HE2  . LYS A 1 127 ? 21.02043 21.83206  7.74747   1.000 11.40976  ? 122 LYS A HE2  1 
ATOM   1943 H HE3  . LYS A 1 127 ? 20.47446 22.27671  6.32282   1.000 11.40976  ? 122 LYS A HE3  1 
ATOM   1944 H HZ1  . LYS A 1 127 ? 21.44281 20.25859  6.13401   1.000 19.05030  ? 122 LYS A HZ1  1 
ATOM   1945 H HZ2  . LYS A 1 127 ? 22.28305 21.18897  5.40825   1.000 19.05030  ? 122 LYS A HZ2  1 
ATOM   1946 H HZ3  . LYS A 1 127 ? 22.68637 20.71837  6.71753   1.000 19.05030  ? 122 LYS A HZ3  1 
ATOM   1947 N N    . MET A 1 128 ? 26.75932 22.70527  7.54901   1.000 22.97488  ? 123 MET A N    1 
ATOM   1948 C CA   . MET A 1 128 ? 27.44696 21.42396  7.36263   1.000 16.18212  ? 123 MET A CA   1 
ATOM   1949 C C    . MET A 1 128 ? 28.45720 21.16157  8.48091   1.000 17.20779  ? 123 MET A C    1 
ATOM   1950 O O    . MET A 1 128 ? 28.61787 20.02032  8.93702   1.000 6.98776   ? 123 MET A O    1 
ATOM   1951 C CB   . MET A 1 128 ? 28.11275 21.47794  5.97955   1.000 18.89138  ? 123 MET A CB   1 
ATOM   1952 C CG   . MET A 1 128 ? 28.79930 20.26862  5.41047   1.000 34.96498  ? 123 MET A CG   1 
ATOM   1953 S SD   . MET A 1 128 ? 28.81148 20.27886  3.56477   1.000 28.76960  ? 123 MET A SD   1 
ATOM   1954 C CE   . MET A 1 128 ? 28.80906 18.54301  3.37540   1.000 19.34270  ? 123 MET A CE   1 
ATOM   1955 H H    . MET A 1 128 ? 26.75531 23.19782  6.84405   1.000 27.59226  ? 123 MET A H    1 
ATOM   1956 H HA   . MET A 1 128 ? 26.82104 20.68321  7.38301   1.000 19.44095  ? 123 MET A HA   1 
ATOM   1957 H HB2  . MET A 1 128 ? 27.42289 21.71705  5.34095   1.000 22.69205  ? 123 MET A HB2  1 
ATOM   1958 H HB3  . MET A 1 128 ? 28.78722 22.17414  6.01556   1.000 22.69205  ? 123 MET A HB3  1 
ATOM   1959 H HG2  . MET A 1 128 ? 29.71876 20.24993  5.71891   1.000 41.98038  ? 123 MET A HG2  1 
ATOM   1960 H HG3  . MET A 1 128 ? 28.33412 19.47018  5.70545   1.000 41.98038  ? 123 MET A HG3  1 
ATOM   1961 H HE1  . MET A 1 128 ? 28.83696 18.32845  2.42984   1.000 23.23364  ? 123 MET A HE1  1 
ATOM   1962 H HE2  . MET A 1 128 ? 29.58835 18.17563  3.82108   1.000 23.23364  ? 123 MET A HE2  1 
ATOM   1963 H HE3  . MET A 1 128 ? 28.00055 18.18314  3.77253   1.000 23.23364  ? 123 MET A HE3  1 
ATOM   1964 N N    . LYS A 1 129 ? 29.15792 22.19953  8.93141   1.000 8.66139   ? 124 LYS A N    1 
ATOM   1965 C CA   . LYS A 1 129 ? 30.14793 22.00974  9.98279   1.000 23.47266  ? 124 LYS A CA   1 
ATOM   1966 C C    . LYS A 1 129 ? 29.48340 21.59574  11.30971  1.000 23.13942  ? 124 LYS A C    1 
ATOM   1967 O O    . LYS A 1 129 ? 29.99758 20.71636  12.02093  1.000 11.59509  ? 124 LYS A O    1 
ATOM   1968 C CB   . LYS A 1 129 ? 30.98117 23.29011  10.11662  1.000 9.35922   ? 124 LYS A CB   1 
ATOM   1969 C CG   . LYS A 1 129 ? 32.17454 23.16430  11.06877  1.000 23.75008  ? 124 LYS A CG   1 
ATOM   1970 C CD   . LYS A 1 129 ? 32.77415 24.52577  11.40921  1.000 19.66161  ? 124 LYS A CD   1 
ATOM   1971 C CE   . LYS A 1 129 ? 34.10562 24.38590  12.09895  1.000 40.14444  ? 124 LYS A CE   1 
ATOM   1972 N NZ   . LYS A 1 129 ? 34.85814 25.65776  12.16725  1.000 31.53806  ? 124 LYS A NZ   1 
ATOM   1973 H H    . LYS A 1 129 ? 29.08009 23.00841  8.64988   1.000 10.41607  ? 124 LYS A H    1 
ATOM   1974 H HA   . LYS A 1 129 ? 30.75441 21.29015  9.74769   1.000 28.18959  ? 124 LYS A HA   1 
ATOM   1975 H HB2  . LYS A 1 129 ? 31.32613 23.52868  9.24198   1.000 11.25347  ? 124 LYS A HB2  1 
ATOM   1976 H HB3  . LYS A 1 129 ? 30.40987 23.99844  10.45244  1.000 11.25347  ? 124 LYS A HB3  1 
ATOM   1977 H HG2  . LYS A 1 129 ? 31.88296 22.74610  11.89399  1.000 28.52249  ? 124 LYS A HG2  1 
ATOM   1978 H HG3  . LYS A 1 129 ? 32.86345 22.62555  10.64919  1.000 28.52249  ? 124 LYS A HG3  1 
ATOM   1979 H HD2  . LYS A 1 129 ? 32.90569 25.03219  10.59243  1.000 23.61633  ? 124 LYS A HD2  1 
ATOM   1980 H HD3  . LYS A 1 129 ? 32.17241 25.00267  12.00198  1.000 23.61633  ? 124 LYS A HD3  1 
ATOM   1981 H HE2  . LYS A 1 129 ? 33.95959 24.07624  13.00652  1.000 48.19573  ? 124 LYS A HE2  1 
ATOM   1982 H HE3  . LYS A 1 129 ? 34.64683 23.74447  11.61259  1.000 48.19573  ? 124 LYS A HE3  1 
ATOM   1983 H HZ1  . LYS A 1 129 ? 35.10474 25.90979  11.35008  1.000 37.86807  ? 124 LYS A HZ1  1 
ATOM   1984 H HZ2  . LYS A 1 129 ? 34.34861 26.29413  12.52433  1.000 37.86807  ? 124 LYS A HZ2  1 
ATOM   1985 H HZ3  . LYS A 1 129 ? 35.58559 25.55444  12.66949  1.000 37.86807  ? 124 LYS A HZ3  1 
ATOM   1986 N N    . GLY A 1 130 ? 28.33661 22.19013  11.64664  1.000 18.24877  ? 125 GLY A N    1 
ATOM   1987 C CA   . GLY A 1 130 ? 27.60998 21.78997  12.84199  1.000 9.96185   ? 125 GLY A CA   1 
ATOM   1988 C C    . GLY A 1 130 ? 26.92684 20.44614  12.72737  1.000 13.98279  ? 125 GLY A C    1 
ATOM   1989 O O    . GLY A 1 130 ? 26.76896 19.74230  13.73237  1.000 12.48380  ? 125 GLY A O    1 
ATOM   1990 H H    . GLY A 1 130 ? 27.96305 22.82345  11.20059  1.000 21.92093  ? 125 GLY A H    1 
ATOM   1991 H HA2  . GLY A 1 130 ? 28.22975 21.74742  13.58695  1.000 11.97662  ? 125 GLY A HA2  1 
ATOM   1992 H HA3  . GLY A 1 130 ? 26.93052 22.45505  13.03406  1.000 11.97662  ? 125 GLY A HA3  1 
ATOM   1993 N N    . ASP A 1 131 ? 26.50988 20.07958  11.51407  1.000 12.87496  ? 126 ASP A N    1 
ATOM   1994 C CA   . ASP A 1 131 ? 26.01058 18.73407  11.23393  1.000 11.88645  ? 126 ASP A CA   1 
ATOM   1995 C C    . ASP A 1 131 ? 27.07620 17.64526  11.46469  1.000 11.15884  ? 126 ASP A C    1 
ATOM   1996 O O    . ASP A 1 131 ? 26.77281 16.59177  12.02705  1.000 7.04341   ? 126 ASP A O    1 
ATOM   1997 C CB   . ASP A 1 131 ? 25.52539 18.66091  9.78629   1.000 11.03570  ? 126 ASP A CB   1 
ATOM   1998 C CG   . ASP A 1 131 ? 24.18314 19.38757  9.54404   1.000 22.61903  ? 126 ASP A CG   1 
ATOM   1999 O OD1  . ASP A 1 131 ? 23.44500 19.73234  10.49679  1.000 18.08072  ? 126 ASP A OD1  1 
ATOM   2000 O OD2  . ASP A 1 131 ? 23.86168 19.57994  8.35235   1.000 16.61105  ? 126 ASP A OD2  1 
ATOM   2001 H H    . ASP A 1 131 ? 26.50557 20.59703  10.82717  1.000 15.47236  ? 126 ASP A H    1 
ATOM   2002 H HA   . ASP A 1 131 ? 25.27287 18.56133  11.83962  1.000 14.28614  ? 126 ASP A HA   1 
ATOM   2003 H HB2  . ASP A 1 131 ? 26.19152 19.07048  9.21233   1.000 13.26524  ? 126 ASP A HB2  1 
ATOM   2004 H HB3  . ASP A 1 131 ? 25.40577 17.72945  9.54345   1.000 13.26524  ? 126 ASP A HB3  1 
ATOM   2005 N N    . TYR A 1 132 ? 28.32809 17.86270  11.02797  1.000 11.87970  ? 127 TYR A N    1 
ATOM   2006 C CA   . TYR A 1 132 ? 29.35205 16.81039  11.15958  1.000 14.30509  ? 127 TYR A CA   1 
ATOM   2007 C C    . TYR A 1 132 ? 30.00785 16.76290  12.54590  1.000 19.75514  ? 127 TYR A C    1 
ATOM   2008 O O    . TYR A 1 132 ? 30.50196 15.69386  12.94555  1.000 21.21518  ? 127 TYR A O    1 
ATOM   2009 C CB   . TYR A 1 132 ? 30.40672 16.92796  10.00869  1.000 17.94211  ? 127 TYR A CB   1 
ATOM   2010 C CG   . TYR A 1 132 ? 29.84415 16.23271  8.73679   1.000 18.05169  ? 127 TYR A CG   1 
ATOM   2011 C CD1  . TYR A 1 132 ? 28.80964 16.82920  7.99427   1.000 3.98961   ? 127 TYR A CD1  1 
ATOM   2012 C CD2  . TYR A 1 132 ? 30.25104 14.96796  8.36334   1.000 7.40928   ? 127 TYR A CD2  1 
ATOM   2013 C CE1  . TYR A 1 132 ? 28.21707 16.20823  6.94073   1.000 12.10678  ? 127 TYR A CE1  1 
ATOM   2014 C CE2  . TYR A 1 132 ? 29.66152 14.32559  7.27231   1.000 14.80947  ? 127 TYR A CE2  1 
ATOM   2015 C CZ   . TYR A 1 132 ? 28.64437 14.96821  6.57216   1.000 29.26644  ? 127 TYR A CZ   1 
ATOM   2016 O OH   . TYR A 1 132 ? 28.02890 14.39567  5.48834   1.000 24.04898  ? 127 TYR A OH   1 
ATOM   2017 H H    . TYR A 1 132 ? 28.60282 18.59074  10.66180  1.000 14.27804  ? 127 TYR A H    1 
ATOM   2018 H HA   . TYR A 1 132 ? 28.92782 15.94544  11.04644  1.000 17.18850  ? 127 TYR A HA   1 
ATOM   2019 H HB2  . TYR A 1 132 ? 30.57612 17.86214  9.80993   1.000 21.55293  ? 127 TYR A HB2  1 
ATOM   2020 H HB3  . TYR A 1 132 ? 31.23151 16.48958  10.27032  1.000 21.55293  ? 127 TYR A HB3  1 
ATOM   2021 H HD1  . TYR A 1 132 ? 28.52028 17.68018  8.23303   1.000 4.80993   ? 127 TYR A HD1  1 
ATOM   2022 H HD2  . TYR A 1 132 ? 30.92350 14.53980  8.84226   1.000 8.91353   ? 127 TYR A HD2  1 
ATOM   2023 H HE1  . TYR A 1 132 ? 27.52746 16.62513  6.47647   1.000 14.55054  ? 127 TYR A HE1  1 
ATOM   2024 H HE2  . TYR A 1 132 ? 29.94540 13.47777  7.01636   1.000 17.79376  ? 127 TYR A HE2  1 
ATOM   2025 H HH   . TYR A 1 132 ? 28.18185 13.56983  5.47415   1.000 28.88118  ? 127 TYR A HH   1 
ATOM   2026 N N    . TYR A 1 133 ? 29.99660 17.86344  13.31159  1.000 22.00097  ? 128 TYR A N    1 
ATOM   2027 C CA   . TYR A 1 133 ? 30.30596 17.73923  14.73940  1.000 9.49831   ? 128 TYR A CA   1 
ATOM   2028 C C    . TYR A 1 133 ? 29.17957 17.03461  15.48855  1.000 13.91494  ? 128 TYR A C    1 
ATOM   2029 O O    . TYR A 1 133 ? 29.45277 16.33571  16.47555  1.000 16.21643  ? 128 TYR A O    1 
ATOM   2030 C CB   . TYR A 1 133 ? 30.56666 19.11186  15.34676  1.000 6.44180   ? 128 TYR A CB   1 
ATOM   2031 C CG   . TYR A 1 133 ? 31.98732 19.57956  15.21264  1.000 11.89962  ? 128 TYR A CG   1 
ATOM   2032 C CD1  . TYR A 1 133 ? 33.00714 18.89954  15.82232  1.000 10.73056  ? 128 TYR A CD1  1 
ATOM   2033 C CD2  . TYR A 1 133 ? 32.31298 20.68591  14.43794  1.000 22.20247  ? 128 TYR A CD2  1 
ATOM   2034 C CE1  . TYR A 1 133 ? 34.29585 19.30617  15.71636  1.000 13.51288  ? 128 TYR A CE1  1 
ATOM   2035 C CE2  . TYR A 1 133 ? 33.61910 21.09154  14.29883  1.000 17.96299  ? 128 TYR A CE2  1 
ATOM   2036 C CZ   . TYR A 1 133 ? 34.60782 20.37767  14.94683  1.000 30.01471  ? 128 TYR A CZ   1 
ATOM   2037 O OH   . TYR A 1 133 ? 35.92662 20.72613  14.88013  1.000 24.16497  ? 128 TYR A OH   1 
ATOM   2038 H H    . TYR A 1 133 ? 29.82028 18.65985  13.03912  1.000 26.42356  ? 128 TYR A H    1 
ATOM   2039 H HA   . TYR A 1 133 ? 31.11553 17.21443  14.83973  1.000 11.42037  ? 128 TYR A HA   1 
ATOM   2040 H HB2  . TYR A 1 133 ? 29.99915 19.76118  14.90268  1.000 7.75256   ? 128 TYR A HB2  1 
ATOM   2041 H HB3  . TYR A 1 133 ? 30.35516 19.07844  16.29283  1.000 7.75256   ? 128 TYR A HB3  1 
ATOM   2042 H HD1  . TYR A 1 133 ? 32.81090 18.13983  16.32153  1.000 12.89908  ? 128 TYR A HD1  1 
ATOM   2043 H HD2  . TYR A 1 133 ? 31.63779 21.15880  14.00737  1.000 26.66536  ? 128 TYR A HD2  1 
ATOM   2044 H HE1  . TYR A 1 133 ? 34.96620 18.84991  16.17173  1.000 16.23785  ? 128 TYR A HE1  1 
ATOM   2045 H HE2  . TYR A 1 133 ? 33.83267 21.83220  13.77853  1.000 21.57798  ? 128 TYR A HE2  1 
ATOM   2046 H HH   . TYR A 1 133 ? 36.05619 21.23645  14.22561  1.000 29.02037  ? 128 TYR A HH   1 
ATOM   2047 N N    . ARG A 1 134 ? 27.91753 17.22967  15.06167  1.000 18.37805  ? 129 ARG A N    1 
ATOM   2048 C CA   . ARG A 1 134 ? 26.79402 16.53136  15.69443  1.000 16.14895  ? 129 ARG A CA   1 
ATOM   2049 C C    . ARG A 1 134 ? 26.92473 15.02070  15.56120  1.000 11.95016  ? 129 ARG A C    1 
ATOM   2050 O O    . ARG A 1 134 ? 26.75122 14.28613  16.54009  1.000 11.59217  ? 129 ARG A O    1 
ATOM   2051 C CB   . ARG A 1 134 ? 25.44810 16.98707  15.10996  1.000 12.93054  ? 129 ARG A CB   1 
ATOM   2052 C CG   . ARG A 1 134 ? 24.22224 16.11399  15.47911  1.000 7.45893   ? 129 ARG A CG   1 
ATOM   2053 C CD   . ARG A 1 134 ? 22.93861 16.91249  15.52502  1.000 14.22915  ? 129 ARG A CD   1 
ATOM   2054 N NE   . ARG A 1 134 ? 22.55391 17.45122  14.21972  1.000 12.64111  ? 129 ARG A NE   1 
ATOM   2055 C CZ   . ARG A 1 134 ? 21.89402 16.77486  13.28602  1.000 14.01374  ? 129 ARG A CZ   1 
ATOM   2056 N NH1  . ARG A 1 134 ? 21.49313 15.53468  13.48217  1.000 6.84511   ? 129 ARG A NH1  1 
ATOM   2057 N NH2  . ARG A 1 134 ? 21.63890 17.35483  12.12399  1.000 8.80857   ? 129 ARG A NH2  1 
ATOM   2058 H H    . ARG A 1 134 ? 27.69294 17.75347  14.41763  1.000 22.07606  ? 129 ARG A H    1 
ATOM   2059 H HA   . ARG A 1 134 ? 26.80709 16.76617  16.63549  1.000 19.40114  ? 129 ARG A HA   1 
ATOM   2060 H HB2  . ARG A 1 134 ? 25.26731 17.88544  15.42800  1.000 15.53905  ? 129 ARG A HB2  1 
ATOM   2061 H HB3  . ARG A 1 134 ? 25.52090 16.98594  14.14270  1.000 15.53905  ? 129 ARG A HB3  1 
ATOM   2062 H HG2  . ARG A 1 134 ? 24.11828 15.41492  14.81474  1.000 8.97311   ? 129 ARG A HG2  1 
ATOM   2063 H HG3  . ARG A 1 134 ? 24.36387 15.72119  16.35464  1.000 8.97311   ? 129 ARG A HG3  1 
ATOM   2064 H HD2  . ARG A 1 134 ? 22.22079 16.33821  15.83461  1.000 17.09738  ? 129 ARG A HD2  1 
ATOM   2065 H HD3  . ARG A 1 134 ? 23.05284 17.65855  16.13432  1.000 17.09738  ? 129 ARG A HD3  1 
ATOM   2066 H HE   . ARG A 1 134 ? 22.77082 18.26475  14.04445  1.000 15.19173  ? 129 ARG A HE   1 
ATOM   2067 H HH11 . ARG A 1 134 ? 21.65728 15.14289  14.22993  1.000 8.23654   ? 129 ARG A HH11 1 
ATOM   2068 H HH12 . ARG A 1 134 ? 21.06741 15.11728  12.86238  1.000 8.23654   ? 129 ARG A HH12 1 
ATOM   2069 H HH21 . ARG A 1 134 ? 21.89972 18.16150  11.97957  1.000 10.59269  ? 129 ARG A HH21 1 
ATOM   2070 H HH22 . ARG A 1 134 ? 21.21232 16.92501  11.51335  1.000 10.59269  ? 129 ARG A HH22 1 
ATOM   2071 N N    . TYR A 1 135 ? 27.16478 14.52646  14.34453  1.000 10.82024  ? 130 TYR A N    1 
ATOM   2072 C CA   . TYR A 1 135 ? 27.27161 13.07159  14.16963  1.000 16.18729  ? 130 TYR A CA   1 
ATOM   2073 C C    . TYR A 1 135 ? 28.41940 12.48874  14.99968  1.000 25.53594  ? 130 TYR A C    1 
ATOM   2074 O O    . TYR A 1 135 ? 28.33075 11.34109  15.45408  1.000 28.28847  ? 130 TYR A O    1 
ATOM   2075 C CB   . TYR A 1 135 ? 27.44813 12.71956  12.69894  1.000 15.41103  ? 130 TYR A CB   1 
ATOM   2076 C CG   . TYR A 1 135 ? 26.39537 13.32918  11.76960  1.000 21.63548  ? 130 TYR A CG   1 
ATOM   2077 C CD1  . TYR A 1 135 ? 25.08011 13.55192  12.19779  1.000 23.17960  ? 130 TYR A CD1  1 
ATOM   2078 C CD2  . TYR A 1 135 ? 26.71802 13.67227  10.46044  1.000 20.68124  ? 130 TYR A CD2  1 
ATOM   2079 C CE1  . TYR A 1 135 ? 24.11354 14.12407  11.34899  1.000 15.93867  ? 130 TYR A CE1  1 
ATOM   2080 C CE2  . TYR A 1 135 ? 25.77314 14.22554  9.60099   1.000 18.57792  ? 130 TYR A CE2  1 
ATOM   2081 C CZ   . TYR A 1 135 ? 24.47255 14.44924  10.04968  1.000 35.19379  ? 130 TYR A CZ   1 
ATOM   2082 O OH   . TYR A 1 135 ? 23.56005 14.99679  9.17068   1.000 17.07255  ? 130 TYR A OH   1 
ATOM   2083 H H    . TYR A 1 135 ? 27.26652 14.99183  13.62851  1.000 13.00669  ? 130 TYR A H    1 
ATOM   2084 H HA   . TYR A 1 135 ? 26.44388 12.66489  14.47021  1.000 19.44715  ? 130 TYR A HA   1 
ATOM   2085 H HB2  . TYR A 1 135 ? 28.31646 13.03838  12.40697  1.000 18.51564  ? 130 TYR A HB2  1 
ATOM   2086 H HB3  . TYR A 1 135 ? 27.39960 11.75544  12.60402  1.000 18.51564  ? 130 TYR A HB3  1 
ATOM   2087 H HD1  . TYR A 1 135 ? 24.83947 13.31587  13.06456  1.000 27.83792  ? 130 TYR A HD1  1 
ATOM   2088 H HD2  . TYR A 1 135 ? 27.58388 13.52883  10.15285  1.000 24.83989  ? 130 TYR A HD2  1 
ATOM   2089 H HE1  . TYR A 1 135 ? 23.24929 14.28120  11.65441  1.000 19.14880  ? 130 TYR A HE1  1 
ATOM   2090 H HE2  . TYR A 1 135 ? 26.00923 14.44560  8.72878   1.000 22.31591  ? 130 TYR A HE2  1 
ATOM   2091 H HH   . TYR A 1 135 ? 22.81852 15.09768  9.55218   1.000 20.50946  ? 130 TYR A HH   1 
ATOM   2092 N N    . LEU A 1 136 ? 29.50115 13.25288  15.20909  1.000 18.44298  ? 131 LEU A N    1 
ATOM   2093 C CA   . LEU A 1 136 ? 30.56207 12.79276  16.09897  1.000 22.77859  ? 131 LEU A CA   1 
ATOM   2094 C C    . LEU A 1 136 ? 30.08086 12.76294  17.53702  1.000 21.77202  ? 131 LEU A C    1 
ATOM   2095 O O    . LEU A 1 136 ? 30.41374 11.84849  18.29884  1.000 17.17177  ? 131 LEU A O    1 
ATOM   2096 C CB   . LEU A 1 136 ? 31.78787 13.70178  16.04928  1.000 20.14276  ? 131 LEU A CB   1 
ATOM   2097 C CG   . LEU A 1 136 ? 32.75919 13.63723  14.87373  1.000 19.85089  ? 131 LEU A CG   1 
ATOM   2098 C CD1  . LEU A 1 136 ? 33.72221 14.84060  14.86306  1.000 11.88649  ? 131 LEU A CD1  1 
ATOM   2099 C CD2  . LEU A 1 136 ? 33.51917 12.34816  14.94422  1.000 24.50352  ? 131 LEU A CD2  1 
ATOM   2100 H H    . LEU A 1 136 ? 29.63764 14.02402  14.85368  1.000 22.15397  ? 131 LEU A H    1 
ATOM   2101 H HA   . LEU A 1 136 ? 30.81738 11.90816  15.79370  1.000 27.35671  ? 131 LEU A HA   1 
ATOM   2102 H HB2  . LEU A 1 136 ? 31.46454 14.61585  16.07804  1.000 24.19371  ? 131 LEU A HB2  1 
ATOM   2103 H HB3  . LEU A 1 136 ? 32.31468 13.51115  16.84113  1.000 24.19371  ? 131 LEU A HB3  1 
ATOM   2104 H HG   . LEU A 1 136 ? 32.26174 13.67486  14.04184  1.000 23.84347  ? 131 LEU A HG   1 
ATOM   2105 H HD11 . LEU A 1 136 ? 33.27207 15.60179  14.46449  1.000 14.28619  ? 131 LEU A HD11 1 
ATOM   2106 H HD12 . LEU A 1 136 ? 33.97833 15.04821  15.77531  1.000 14.28619  ? 131 LEU A HD12 1 
ATOM   2107 H HD13 . LEU A 1 136 ? 34.50819 14.61148  14.34282  1.000 14.28619  ? 131 LEU A HD13 1 
ATOM   2108 H HD21 . LEU A 1 136 ? 34.18835 12.33728  14.24209  1.000 29.42662  ? 131 LEU A HD21 1 
ATOM   2109 H HD22 . LEU A 1 136 ? 33.94856 12.28173  15.81146  1.000 29.42662  ? 131 LEU A HD22 1 
ATOM   2110 H HD23 . LEU A 1 136 ? 32.90123 11.61024  14.82368  1.000 29.42662  ? 131 LEU A HD23 1 
ATOM   2111 N N    . ALA A 1 137 ? 29.35508 13.80006  17.94456  1.000 24.22100  ? 132 ALA A N    1 
ATOM   2112 C CA   . ALA A 1 137 ? 28.84889 13.81279  19.30682  1.000 25.43440  ? 132 ALA A CA   1 
ATOM   2113 C C    . ALA A 1 137 ? 27.90526 12.64258  19.54294  1.000 17.84240  ? 132 ALA A C    1 
ATOM   2114 O O    . ALA A 1 137 ? 27.81277 12.16828  20.67465  1.000 16.93285  ? 132 ALA A O    1 
ATOM   2115 C CB   . ALA A 1 137 ? 28.14499 15.13384  19.61889  1.000 26.69289  ? 132 ALA A CB   1 
ATOM   2116 H H    . ALA A 1 137 ? 29.14951 14.48490  17.46672  1.000 29.08760  ? 132 ALA A H    1 
ATOM   2117 H HA   . ALA A 1 137 ? 29.59933 13.73946  19.91704  1.000 30.54368  ? 132 ALA A HA   1 
ATOM   2118 H HB1  . ALA A 1 137 ? 28.80165 15.84775  19.62526  1.000 32.05387  ? 132 ALA A HB1  1 
ATOM   2119 H HB2  . ALA A 1 137 ? 27.47718 15.30475  18.93646  1.000 32.05387  ? 132 ALA A HB2  1 
ATOM   2120 H HB3  . ALA A 1 137 ? 27.72002 15.06755  20.48832  1.000 32.05387  ? 132 ALA A HB3  1 
ATOM   2121 N N    . GLU A 1 138 ? 27.22492 12.14400  18.49299  1.000 16.48580  ? 133 GLU A N    1 
ATOM   2122 C CA   . GLU A 1 138 ? 26.24314 11.08063  18.71338  1.000 11.53086  ? 133 GLU A CA   1 
ATOM   2123 C C    . GLU A 1 138 ? 26.89167 9.80637   19.26463  1.000 19.14564  ? 133 GLU A C    1 
ATOM   2124 O O    . GLU A 1 138 ? 26.20589 9.00507   19.90569  1.000 20.57168  ? 133 GLU A O    1 
ATOM   2125 C CB   . GLU A 1 138 ? 25.48761 10.76034  17.42140  1.000 11.78215  ? 133 GLU A CB   1 
ATOM   2126 C CG   . GLU A 1 138 ? 24.23129 11.67864  17.09186  1.000 16.12078  ? 133 GLU A CG   1 
ATOM   2127 C CD   . GLU A 1 138 ? 23.67095 11.44763  15.67428  1.000 16.46635  ? 133 GLU A CD   1 
ATOM   2128 O OE1  . GLU A 1 138 ? 24.34219 10.80728  14.84699  1.000 25.32506  ? 133 GLU A OE1  1 
ATOM   2129 O OE2  . GLU A 1 138 ? 22.56261 11.88880  15.37016  1.000 19.00173  ? 133 GLU A OE2  1 
ATOM   2130 H H    . GLU A 1 138 ? 27.31404 12.39838  17.67632  1.000 19.80536  ? 133 GLU A H    1 
ATOM   2131 H HA   . GLU A 1 138 ? 25.59273 11.39759  19.35945  1.000 13.85943  ? 133 GLU A HA   1 
ATOM   2132 H HB2  . GLU A 1 138 ? 26.10700 10.84806  16.68007  1.000 14.16098  ? 133 GLU A HB2  1 
ATOM   2133 H HB3  . GLU A 1 138 ? 25.16586 9.84704   17.47859  1.000 14.16098  ? 133 GLU A HB3  1 
ATOM   2134 H HG2  . GLU A 1 138 ? 23.52456 11.48571  17.72764  1.000 19.36734  ? 133 GLU A HG2  1 
ATOM   2135 H HG3  . GLU A 1 138 ? 24.49471 12.60962  17.16101  1.000 19.36734  ? 133 GLU A HG3  1 
ATOM   2136 N N    . VAL A 1 139 ? 28.19604 9.62621   19.03793  1.000 16.85567  ? 134 VAL A N    1 
ATOM   2137 C CA   . VAL A 1 139 ? 28.98940 8.46388   19.41020  1.000 23.31107  ? 134 VAL A CA   1 
ATOM   2138 C C    . VAL A 1 139 ? 30.12765 8.80622   20.37722  1.000 24.38016  ? 134 VAL A C    1 
ATOM   2139 O O    . VAL A 1 139 ? 31.00902 7.97288   20.59732  1.000 25.88692  ? 134 VAL A O    1 
ATOM   2140 C CB   . VAL A 1 139 ? 29.57939 7.76773   18.16300  1.000 18.95162  ? 134 VAL A CB   1 
ATOM   2141 C CG1  . VAL A 1 139 ? 28.57604 7.60227   17.03788  1.000 22.68777  ? 134 VAL A CG1  1 
ATOM   2142 C CG2  . VAL A 1 139 ? 30.71151 8.55423   17.65561  1.000 18.84620  ? 134 VAL A CG2  1 
ATOM   2143 H H    . VAL A 1 139 ? 28.67792 10.21479  18.63671  1.000 20.24921  ? 134 VAL A H    1 
ATOM   2144 H HA   . VAL A 1 139 ? 28.39104 7.85025   19.86444  1.000 27.99568  ? 134 VAL A HA   1 
ATOM   2145 H HB   . VAL A 1 139 ? 29.85694 6.88054   18.44004  1.000 22.76434  ? 134 VAL A HB   1 
ATOM   2146 H HG11 . VAL A 1 139 ? 27.68191 7.57786   17.41315  1.000 27.24772  ? 134 VAL A HG11 1 
ATOM   2147 H HG12 . VAL A 1 139 ? 28.65857 8.35228   16.42831  1.000 27.24772  ? 134 VAL A HG12 1 
ATOM   2148 H HG13 . VAL A 1 139 ? 28.76086 6.77331   16.56931  1.000 27.24772  ? 134 VAL A HG13 1 
ATOM   2149 H HG21 . VAL A 1 139 ? 30.53457 9.49597   17.80632  1.000 22.63784  ? 134 VAL A HG21 1 
ATOM   2150 H HG22 . VAL A 1 139 ? 31.51667 8.28933   18.12725  1.000 22.63784  ? 134 VAL A HG22 1 
ATOM   2151 H HG23 . VAL A 1 139 ? 30.81348 8.38466   16.70601  1.000 22.63784  ? 134 VAL A HG23 1 
ATOM   2152 N N    . ALA A 1 140 ? 30.14543 10.02511  20.94967  1.000 24.22037  ? 135 ALA A N    1 
ATOM   2153 C CA   . ALA A 1 140 ? 31.21722 10.43262  21.86288  1.000 38.04148  ? 135 ALA A CA   1 
ATOM   2154 C C    . ALA A 1 140 ? 30.88381 10.09253  23.30710  1.000 26.36964  ? 135 ALA A C    1 
ATOM   2155 O O    . ALA A 1 140 ? 29.73816 10.22470  23.73519  1.000 34.09380  ? 135 ALA A O    1 
ATOM   2156 C CB   . ALA A 1 140 ? 31.48713 11.93582  21.78282  1.000 26.37375  ? 135 ALA A CB   1 
ATOM   2157 H H    . ALA A 1 140 ? 29.54640 10.62872  20.82152  1.000 29.08685  ? 135 ALA A H    1 
ATOM   2158 H HA   . ALA A 1 140 ? 32.01483 9.94809   21.59840  1.000 45.67218  ? 135 ALA A HA   1 
ATOM   2159 H HB1  . ALA A 1 140 ? 30.65167 12.41357  21.90392  1.000 31.67090  ? 135 ALA A HB1  1 
ATOM   2160 H HB2  . ALA A 1 140 ? 32.11321 12.18192  22.48164  1.000 31.67090  ? 135 ALA A HB2  1 
ATOM   2161 H HB3  . ALA A 1 140 ? 31.86370 12.14318  20.91328  1.000 31.67090  ? 135 ALA A HB3  1 
ATOM   2162 N N    . THR A 1 141 ? 31.89662 9.69730   24.06883  1.000 27.29648  ? 136 THR A N    1 
ATOM   2163 C CA   . THR A 1 141 ? 31.66635 9.40223   25.47828  1.000 58.92456  ? 136 THR A CA   1 
ATOM   2164 C C    . THR A 1 141 ? 32.79929 9.80917   26.40774  1.000 59.70031  ? 136 THR A C    1 
ATOM   2165 O O    . THR A 1 141 ? 32.69564 9.54541   27.60696  1.000 40.51369  ? 136 THR A O    1 
ATOM   2166 C CB   . THR A 1 141 ? 31.41684 7.89828   25.70301  1.000 51.32158  ? 136 THR A CB   1 
ATOM   2167 O OG1  . THR A 1 141 ? 32.63553 7.17748   25.46997  1.000 59.92627  ? 136 THR A OG1  1 
ATOM   2168 C CG2  . THR A 1 141 ? 30.31176 7.38695   24.79235  1.000 43.67161  ? 136 THR A CG2  1 
ATOM   2169 H H    . THR A 1 141 ? 32.70722 9.59451   23.80058  1.000 32.77818  ? 136 THR A H    1 
ATOM   2170 H HA   . THR A 1 141 ? 30.86970 9.89515   25.72985  1.000 70.73187  ? 136 THR A HA   1 
ATOM   2171 H HB   . THR A 1 141 ? 31.12757 7.74531   26.61615  1.000 61.60830  ? 136 THR A HB   1 
ATOM   2172 H HG1  . THR A 1 141 ? 32.52546 6.36313   25.64410  1.000 71.93392  ? 136 THR A HG1  1 
ATOM   2173 H HG21 . THR A 1 141 ? 30.14367 6.44819   24.96949  1.000 52.42833  ? 136 THR A HG21 1 
ATOM   2174 H HG22 . THR A 1 141 ? 29.49562 7.88766   24.94764  1.000 52.42833  ? 136 THR A HG22 1 
ATOM   2175 H HG23 . THR A 1 141 ? 30.57263 7.49030   23.86382  1.000 52.42833  ? 136 THR A HG23 1 
ATOM   2176 N N    . GLY A 1 142 ? 33.87108 10.41699  25.90609  1.000 65.55511  ? 137 GLY A N    1 
ATOM   2177 C CA   . GLY A 1 142 ? 35.04341 10.72457  26.69845  1.000 57.72291  ? 137 GLY A CA   1 
ATOM   2178 C C    . GLY A 1 142 ? 35.03954 12.14325  27.23708  1.000 60.56063  ? 137 GLY A C    1 
ATOM   2179 O O    . GLY A 1 142 ? 33.99194 12.78390  27.38377  1.000 68.19799  ? 137 GLY A O    1 
ATOM   2180 H H    . GLY A 1 142 ? 33.93860 10.66547  25.08554  1.000 78.68854  ? 137 GLY A H    1 
ATOM   2181 H HA2  . GLY A 1 142 ? 35.08810 10.11464  27.45137  1.000 69.28989  ? 137 GLY A HA2  1 
ATOM   2182 H HA3  . GLY A 1 142 ? 35.83648 10.61010  26.15179  1.000 69.28989  ? 137 GLY A HA3  1 
ATOM   2183 N N    . ASP A 1 143 ? 36.24138 12.64033  27.55079  1.000 37.62628  ? 138 ASP A N    1 
ATOM   2184 C CA   . ASP A 1 143 ? 36.36682 14.02291  28.01565  1.000 81.23751  ? 138 ASP A CA   1 
ATOM   2185 C C    . ASP A 1 143 ? 36.12863 15.02424  26.89021  1.000 76.37095  ? 138 ASP A C    1 
ATOM   2186 O O    . ASP A 1 143 ? 35.58550 16.11385  27.11677  1.000 63.50508  ? 138 ASP A O    1 
ATOM   2187 C CB   . ASP A 1 143 ? 37.75001 14.24656  28.63260  1.000 99.36150  ? 138 ASP A CB   1 
ATOM   2188 H H    . ASP A 1 143 ? 36.98273 12.20696  27.50401  1.000 45.17394  ? 138 ASP A H    1 
ATOM   2189 H HA   . ASP A 1 143 ? 35.69894 14.17828  28.70171  1.000 97.50741  ? 138 ASP A HA   1 
ATOM   2190 N N    . ASP A 1 144 ? 36.53874 14.67492  25.67660  1.000 55.53063  ? 139 ASP A N    1 
ATOM   2191 C CA   . ASP A 1 144 ? 36.24770 15.50979  24.53265  1.000 47.52889  ? 139 ASP A CA   1 
ATOM   2192 C C    . ASP A 1 144 ? 34.76820 15.54209  24.13965  1.000 36.09953  ? 139 ASP A C    1 
ATOM   2193 O O    . ASP A 1 144 ? 34.46924 16.19604  23.15373  1.000 37.49758  ? 139 ASP A O    1 
ATOM   2194 C CB   . ASP A 1 144 ? 37.11119 15.03827  23.34658  1.000 57.77530  ? 139 ASP A CB   1 
ATOM   2195 H H    . ASP A 1 144 ? 36.98449 13.96195  25.49607  1.000 66.65915  ? 139 ASP A H    1 
ATOM   2196 H HA   . ASP A 1 144 ? 36.48379 16.42605  24.74627  1.000 57.05707  ? 139 ASP A HA   1 
ATOM   2197 N N    . LYS A 1 145 ? 33.81774 14.88729  24.85959  1.000 37.04799  ? 140 LYS A N    1 
ATOM   2198 C CA   . LYS A 1 145 ? 32.41150 14.94238  24.43630  1.000 21.86635  ? 140 LYS A CA   1 
ATOM   2199 C C    . LYS A 1 145 ? 31.78909 16.31703  24.68678  1.000 42.53130  ? 140 LYS A C    1 
ATOM   2200 O O    . LYS A 1 145 ? 30.94695 16.77898  23.90368  1.000 28.17418  ? 140 LYS A O    1 
ATOM   2201 C CB   . LYS A 1 145 ? 31.58231 13.89067  25.16079  1.000 23.38234  ? 140 LYS A CB   1 
ATOM   2202 C CG   . LYS A 1 145 ? 30.29174 13.56399  24.41315  1.000 23.12199  ? 140 LYS A CG   1 
ATOM   2203 C CD   . LYS A 1 145 ? 29.07294 13.45668  25.30399  1.000 33.24983  ? 140 LYS A CD   1 
ATOM   2204 C CE   . LYS A 1 145 ? 27.84283 12.99808  24.51855  1.000 26.68556  ? 140 LYS A CE   1 
ATOM   2205 N NZ   . LYS A 1 145 ? 26.90954 12.24076  25.43904  1.000 42.84633  ? 140 LYS A NZ   1 
ATOM   2206 H H    . LYS A 1 145 ? 33.96525 14.42406  25.56900  1.000 44.47999  ? 140 LYS A H    1 
ATOM   2207 H HA   . LYS A 1 145 ? 32.39540 14.75603  23.48451  1.000 26.26202  ? 140 LYS A HA   1 
ATOM   2208 H HB2  . LYS A 1 145 ? 32.10152 13.07522  25.24057  1.000 28.08121  ? 140 LYS A HB2  1 
ATOM   2209 H HB3  . LYS A 1 145 ? 31.34720 14.22179  26.04168  1.000 28.08121  ? 140 LYS A HB3  1 
ATOM   2210 H HG2  . LYS A 1 145 ? 30.12125 14.26515  23.76492  1.000 27.76879  ? 140 LYS A HG2  1 
ATOM   2211 H HG3  . LYS A 1 145 ? 30.40085 12.71305  23.96048  1.000 27.76879  ? 140 LYS A HG3  1 
ATOM   2212 H HD2  . LYS A 1 145 ? 29.24443 12.81025  26.00658  1.000 39.92220  ? 140 LYS A HD2  1 
ATOM   2213 H HD3  . LYS A 1 145 ? 28.88087 14.32486  25.69163  1.000 39.92220  ? 140 LYS A HD3  1 
ATOM   2214 H HE2  . LYS A 1 145 ? 27.37420 13.76891  24.16202  1.000 32.04507  ? 140 LYS A HE2  1 
ATOM   2215 H HE3  . LYS A 1 145 ? 28.11437 12.41125  23.79550  1.000 32.04507  ? 140 LYS A HE3  1 
ATOM   2216 H HZ1  . LYS A 1 145 ? 27.35695 11.60183  25.86762  1.000 51.43800  ? 140 LYS A HZ1  1 
ATOM   2217 H HZ2  . LYS A 1 145 ? 26.55513 12.79623  26.03732  1.000 51.43800  ? 140 LYS A HZ2  1 
ATOM   2218 H HZ3  . LYS A 1 145 ? 26.25358 11.86741  24.96742  1.000 51.43800  ? 140 LYS A HZ3  1 
ATOM   2219 N N    . LYS A 1 146 ? 32.15812 16.97591  25.78925  1.000 32.81629  ? 141 LYS A N    1 
ATOM   2220 C CA   . LYS A 1 146 ? 31.63268 18.31617  26.02088  1.000 35.53366  ? 141 LYS A CA   1 
ATOM   2221 C C    . LYS A 1 146 ? 32.25146 19.30354  25.04710  1.000 23.94885  ? 141 LYS A C    1 
ATOM   2222 O O    . LYS A 1 146 ? 31.59294 20.26909  24.66289  1.000 37.81225  ? 141 LYS A O    1 
ATOM   2223 C CB   . LYS A 1 146 ? 31.87612 18.76770  27.46501  1.000 21.23327  ? 141 LYS A CB   1 
ATOM   2224 H H    . LYS A 1 146 ? 32.69163 16.67791  26.39437  1.000 39.40194  ? 141 LYS A H    1 
ATOM   2225 H HA   . LYS A 1 146 ? 30.67135 18.30073  25.89241  1.000 42.66279  ? 141 LYS A HA   1 
ATOM   2226 N N    . ARG A 1 147 ? 33.50652 19.06243  24.63152  1.000 24.39737  ? 142 ARG A N    1 
ATOM   2227 C CA   . ARG A 1 147 ? 34.17458 19.90981  23.64356  1.000 30.31222  ? 142 ARG A CA   1 
ATOM   2228 C C    . ARG A 1 147 ? 33.52943 19.79085  22.26717  1.000 29.89686  ? 142 ARG A C    1 
ATOM   2229 O O    . ARG A 1 147 ? 33.40938 20.78315  21.55003  1.000 33.35790  ? 142 ARG A O    1 
ATOM   2230 C CB   . ARG A 1 147 ? 35.65502 19.53019  23.53726  1.000 45.96578  ? 142 ARG A CB   1 
ATOM   2231 C CG   . ARG A 1 147 ? 36.61827 20.40207  24.36453  1.000 63.77525  ? 142 ARG A CG   1 
ATOM   2232 C CD   . ARG A 1 147 ? 37.79830 19.59770  24.93102  1.000 74.50171  ? 142 ARG A CD   1 
ATOM   2233 N NE   . ARG A 1 147 ? 38.43842 20.28206  26.05193  1.000 59.52792  ? 142 ARG A NE   1 
ATOM   2234 C CZ   . ARG A 1 147 ? 38.73071 19.73137  27.22853  1.000 49.09796  ? 142 ARG A CZ   1 
ATOM   2235 N NH1  . ARG A 1 147 ? 38.43958 18.46720  27.50136  1.000 47.78725  ? 142 ARG A NH1  1 
ATOM   2236 N NH2  . ARG A 1 147 ? 39.34172 20.46918  28.15378  1.000 65.76461  ? 142 ARG A NH2  1 
ATOM   2237 H H    . ARG A 1 147 ? 33.99227 18.40978  24.91024  1.000 29.29925  ? 142 ARG A H    1 
ATOM   2238 H HA   . ARG A 1 147 ? 34.10175 20.82947  23.94324  1.000 36.39706  ? 142 ARG A HA   1 
ATOM   2239 H HB2  . ARG A 1 147 ? 35.75879 18.61503  23.84158  1.000 55.18133  ? 142 ARG A HB2  1 
ATOM   2240 H HB3  . ARG A 1 147 ? 35.92364 19.60331  22.60807  1.000 55.18133  ? 142 ARG A HB3  1 
ATOM   2241 H HG2  . ARG A 1 147 ? 36.97660 21.10395  23.79897  1.000 76.55270  ? 142 ARG A HG2  1 
ATOM   2242 H HG3  . ARG A 1 147 ? 36.13415 20.79111  25.10962  1.000 76.55270  ? 142 ARG A HG3  1 
ATOM   2243 H HD2  . ARG A 1 147 ? 37.47731 18.73766  25.24439  1.000 89.42445  ? 142 ARG A HD2  1 
ATOM   2244 H HD3  . ARG A 1 147 ? 38.46162 19.47062  24.23478  1.000 89.42445  ? 142 ARG A HD3  1 
ATOM   2245 H HE   . ARG A 1 147 ? 38.64365 21.11003  25.94266  1.000 71.45591  ? 142 ARG A HE   1 
ATOM   2246 H HH11 . ARG A 1 147 ? 38.05093 17.97822  26.91022  1.000 57.36711  ? 142 ARG A HH11 1 
ATOM   2247 H HH12 . ARG A 1 147 ? 38.63937 18.13606  28.26949  1.000 57.36711  ? 142 ARG A HH12 1 
ATOM   2248 H HH21 . ARG A 1 147 ? 39.54173 21.28882  27.98706  1.000 78.93994  ? 142 ARG A HH21 1 
ATOM   2249 H HH22 . ARG A 1 147 ? 39.53626 20.12597  28.91795  1.000 78.93994  ? 142 ARG A HH22 1 
ATOM   2250 N N    . ILE A 1 148 ? 33.13179 18.58531  21.86896  1.000 20.91657  ? 143 ILE A N    1 
ATOM   2251 C CA   . ILE A 1 148 ? 32.48477 18.42680  20.57015  1.000 27.15316  ? 143 ILE A CA   1 
ATOM   2252 C C    . ILE A 1 148 ? 31.12364 19.12053  20.56532  1.000 22.74388  ? 143 ILE A C    1 
ATOM   2253 O O    . ILE A 1 148 ? 30.78900 19.85359  19.62304  1.000 26.82978  ? 143 ILE A O    1 
ATOM   2254 C CB   . ILE A 1 148 ? 32.39483 16.93103  20.22176  1.000 31.00168  ? 143 ILE A CB   1 
ATOM   2255 C CG1  . ILE A 1 148 ? 33.80785 16.34859  20.03394  1.000 38.85512  ? 143 ILE A CG1  1 
ATOM   2256 C CG2  . ILE A 1 148 ? 31.56587 16.69338  18.96689  1.000 40.63684  ? 143 ILE A CG2  1 
ATOM   2257 C CD1  . ILE A 1 148 ? 33.88144 14.80243  20.14676  1.000 25.46660  ? 143 ILE A CD1  1 
ATOM   2258 H H    . ILE A 1 148 ? 33.22241 17.85930  22.32095  1.000 25.12228  ? 143 ILE A H    1 
ATOM   2259 H HA   . ILE A 1 148 ? 33.02072 18.85641  19.88523  1.000 32.60619  ? 143 ILE A HA   1 
ATOM   2260 H HB   . ILE A 1 148 ? 31.95314 16.48470  20.96108  1.000 37.22441  ? 143 ILE A HB   1 
ATOM   2261 H HG12 . ILE A 1 148 ? 34.12963 16.59445  19.15252  1.000 46.64855  ? 143 ILE A HG12 1 
ATOM   2262 H HG13 . ILE A 1 148 ? 34.38944 16.72084  20.71519  1.000 46.64855  ? 143 ILE A HG13 1 
ATOM   2263 H HG21 . ILE A 1 148 ? 30.65908 16.99949  19.12476  1.000 48.78660  ? 143 ILE A HG21 1 
ATOM   2264 H HG22 . ILE A 1 148 ? 31.95852 17.18803  18.23065  1.000 48.78660  ? 143 ILE A HG22 1 
ATOM   2265 H HG23 . ILE A 1 148 ? 31.56422 15.74474  18.76445  1.000 48.78660  ? 143 ILE A HG23 1 
ATOM   2266 H HD11 . ILE A 1 148 ? 34.80973 14.53628  20.23812  1.000 30.58232  ? 143 ILE A HD11 1 
ATOM   2267 H HD12 . ILE A 1 148 ? 33.37769 14.51828  20.92548  1.000 30.58232  ? 143 ILE A HD12 1 
ATOM   2268 H HD13 . ILE A 1 148 ? 33.50182 14.40890  19.34556  1.000 30.58232  ? 143 ILE A HD13 1 
ATOM   2269 N N    . ILE A 1 149 ? 30.34689 18.96206  21.64151  1.000 20.72480  ? 144 ILE A N    1 
ATOM   2270 C CA   . ILE A 1 149 ? 29.03506 19.60230  21.72273  1.000 18.12958  ? 144 ILE A CA   1 
ATOM   2271 C C    . ILE A 1 149 ? 29.13028 21.12579  21.60721  1.000 23.11720  ? 144 ILE A C    1 
ATOM   2272 O O    . ILE A 1 149 ? 28.15249 21.79034  21.23346  1.000 15.06568  ? 144 ILE A O    1 
ATOM   2273 C CB   . ILE A 1 149 ? 28.32477 19.20553  23.04581  1.000 26.34918  ? 144 ILE A CB   1 
ATOM   2274 C CG1  . ILE A 1 149 ? 27.87119 17.74491  22.98349  1.000 26.04611  ? 144 ILE A CG1  1 
ATOM   2275 C CG2  . ILE A 1 149 ? 27.14685 20.13139  23.33710  1.000 14.05558  ? 144 ILE A CG2  1 
ATOM   2276 C CD1  . ILE A 1 149 ? 27.17232 17.25824  24.23156  1.000 37.48691  ? 144 ILE A CD1  1 
ATOM   2277 H H    . ILE A 1 149 ? 30.55595 18.49268  22.33113  1.000 24.89216  ? 144 ILE A H    1 
ATOM   2278 H HA   . ILE A 1 149 ? 28.50360 19.28091  20.97764  1.000 21.77790  ? 144 ILE A HA   1 
ATOM   2279 H HB   . ILE A 1 149 ? 28.96091 19.30109  23.77183  1.000 31.64141  ? 144 ILE A HB   1 
ATOM   2280 H HG12 . ILE A 1 149 ? 27.25371 17.64346  22.24233  1.000 31.27773  ? 144 ILE A HG12 1 
ATOM   2281 H HG13 . ILE A 1 149 ? 28.65041 17.18400  22.84527  1.000 31.27773  ? 144 ILE A HG13 1 
ATOM   2282 H HG21 . ILE A 1 149 ? 26.52734 19.67742  23.92956  1.000 16.88910  ? 144 ILE A HG21 1 
ATOM   2283 H HG22 . ILE A 1 149 ? 27.47730 20.93932  23.76014  1.000 16.88910  ? 144 ILE A HG22 1 
ATOM   2284 H HG23 . ILE A 1 149 ? 26.70475 20.35214  22.50240  1.000 16.88910  ? 144 ILE A HG23 1 
ATOM   2285 H HD11 . ILE A 1 149 ? 26.24874 17.55408  24.21206  1.000 45.00669  ? 144 ILE A HD11 1 
ATOM   2286 H HD12 . ILE A 1 149 ? 27.20881 16.28925  24.25646  1.000 45.00669  ? 144 ILE A HD12 1 
ATOM   2287 H HD13 . ILE A 1 149 ? 27.62120 17.62624  25.00872  1.000 45.00669  ? 144 ILE A HD13 1 
ATOM   2288 N N    . ASP A 1 150 ? 30.28636 21.69301  21.92376  1.000 12.50912  ? 145 ASP A N    1 
ATOM   2289 C CA   . ASP A 1 150 ? 30.43557 23.13487  21.91441  1.000 21.02749  ? 145 ASP A CA   1 
ATOM   2290 C C    . ASP A 1 150 ? 30.92299 23.66285  20.57105  1.000 23.33434  ? 145 ASP A C    1 
ATOM   2291 O O    . ASP A 1 150 ? 30.54809 24.77804  20.17453  1.000 13.45430  ? 145 ASP A O    1 
ATOM   2292 C CB   . ASP A 1 150 ? 31.39809 23.55732  23.02650  1.000 24.61235  ? 145 ASP A CB   1 
ATOM   2293 C CG   . ASP A 1 150 ? 31.79041 25.00134  22.91682  1.000 35.15425  ? 145 ASP A CG   1 
ATOM   2294 O OD1  . ASP A 1 150 ? 30.91691 25.88089  23.16296  1.000 33.05342  ? 145 ASP A OD1  1 
ATOM   2295 O OD2  . ASP A 1 150 ? 32.96813 25.24172  22.54658  1.000 39.16456  ? 145 ASP A OD2  1 
ATOM   2296 H H    . ASP A 1 150 ? 30.99690 21.26294  22.14687  1.000 15.03334  ? 145 ASP A H    1 
ATOM   2297 H HA   . ASP A 1 150 ? 29.57717 23.54976  22.09308  1.000 25.25538  ? 145 ASP A HA   1 
ATOM   2298 H HB2  . ASP A 1 150 ? 30.96904 23.42488  23.88631  1.000 29.55723  ? 145 ASP A HB2  1 
ATOM   2299 H HB3  . ASP A 1 150 ? 32.20376 23.01994  22.97148  1.000 29.55723  ? 145 ASP A HB3  1 
ATOM   2300 N N    . SER A 1 151 ? 31.74440 22.87570  19.86440  1.000 20.55397  ? 146 SER A N    1 
ATOM   2301 C CA   . SER A 1 151 ? 32.07341 23.17764  18.46558  1.000 19.48431  ? 146 SER A CA   1 
ATOM   2302 C C    . SER A 1 151 ? 30.83110 23.17534  17.57971  1.000 11.31544  ? 146 SER A C    1 
ATOM   2303 O O    . SER A 1 151 ? 30.65437 24.07818  16.76168  1.000 7.86807   ? 146 SER A O    1 
ATOM   2304 C CB   . SER A 1 151 ? 33.07197 22.15792  17.94321  1.000 10.94055  ? 146 SER A CB   1 
ATOM   2305 O OG   . SER A 1 151 ? 34.26087 22.15702  18.72163  1.000 33.97396  ? 146 SER A OG   1 
ATOM   2306 H H    . SER A 1 151 ? 32.12208 22.16560  20.16890  1.000 24.68717  ? 146 SER A H    1 
ATOM   2307 H HA   . SER A 1 151 ? 32.46986 24.06228  18.43191  1.000 23.40357  ? 146 SER A HA   1 
ATOM   2308 H HB2  . SER A 1 151 ? 32.67008 21.27595  17.98228  1.000 13.15106  ? 146 SER A HB2  1 
ATOM   2309 H HB3  . SER A 1 151 ? 33.29696 22.37965  17.02609  1.000 13.15106  ? 146 SER A HB3  1 
ATOM   2310 H HG   . SER A 1 151 ? 34.73651 21.49501  18.51888  1.000 40.79115  ? 146 SER A HG   1 
ATOM   2311 N N    . ALA A 1 152 ? 29.95996 22.16111  17.72924  1.000 14.81026  ? 147 ALA A N    1 
ATOM   2312 C CA   . ALA A 1 152 ? 28.71863 22.12101  16.95286  1.000 12.44921  ? 147 ALA A CA   1 
ATOM   2313 C C    . ALA A 1 152 ? 27.85239 23.33574  17.25396  1.000 14.39956  ? 147 ALA A C    1 
ATOM   2314 O O    . ALA A 1 152 ? 27.36313 24.00006  16.33118  1.000 18.64449  ? 147 ALA A O    1 
ATOM   2315 C CB   . ALA A 1 152 ? 27.93164 20.83413  17.21748  1.000 6.89043   ? 147 ALA A CB   1 
ATOM   2316 H H    . ALA A 1 152 ? 30.06634 21.49732  18.26559  1.000 17.79471  ? 147 ALA A H    1 
ATOM   2317 H HA   . ALA A 1 152 ? 28.95776 22.12527  16.01281  1.000 14.96145  ? 147 ALA A HA   1 
ATOM   2318 H HB1  . ALA A 1 152 ? 27.69532 20.79612  18.15749  1.000 8.29092   ? 147 ALA A HB1  1 
ATOM   2319 H HB2  . ALA A 1 152 ? 27.12801 20.83806  16.67428  1.000 8.29092   ? 147 ALA A HB2  1 
ATOM   2320 H HB3  . ALA A 1 152 ? 28.48473 20.07213  16.98438  1.000 8.29092   ? 147 ALA A HB3  1 
ATOM   2321 N N    A ARG A 1 153 ? 27.64265 23.62898  18.54758  0.512 16.89792  ? 148 ARG A N    1 
ATOM   2322 N N    B ARG A 1 153 ? 27.66924 23.64750  18.54256  0.488 16.87457  ? 148 ARG A N    1 
ATOM   2323 C CA   A ARG A 1 153 ? 26.87910 24.80197  18.96966  0.512 12.69181  ? 148 ARG A CA   1 
ATOM   2324 C CA   B ARG A 1 153 ? 26.85771 24.79292  18.94176  0.488 15.00995  ? 148 ARG A CA   1 
ATOM   2325 C C    A ARG A 1 153 ? 27.40765 26.07491  18.32214  0.512 14.55300  ? 148 ARG A C    1 
ATOM   2326 C C    B ARG A 1 153 ? 27.39739 26.09352  18.35283  0.488 14.43106  ? 148 ARG A C    1 
ATOM   2327 O O    A ARG A 1 153 ? 26.65241 26.84799  17.72094  0.512 15.40926  ? 148 ARG A O    1 
ATOM   2328 O O    B ARG A 1 153 ? 26.63677 26.90451  17.81145  0.488 15.46968  ? 148 ARG A O    1 
ATOM   2329 C CB   A ARG A 1 153 ? 26.93251 24.93516  20.49946  0.512 21.50025  ? 148 ARG A CB   1 
ATOM   2330 C CB   B ARG A 1 153 ? 26.80550 24.87160  20.47032  0.488 21.50638  ? 148 ARG A CB   1 
ATOM   2331 C CG   A ARG A 1 153 ? 26.28433 26.22448  21.10396  0.512 18.58238  ? 148 ARG A CG   1 
ATOM   2332 C CG   B ARG A 1 153 ? 25.88020 25.95767  21.07013  0.488 17.27366  ? 148 ARG A CG   1 
ATOM   2333 C CD   A ARG A 1 153 ? 26.89800 26.60532  22.48300  0.512 17.89622  ? 148 ARG A CD   1 
ATOM   2334 C CD   B ARG A 1 153 ? 25.78835 25.80816  22.60217  0.488 17.32218  ? 148 ARG A CD   1 
ATOM   2335 N NE   A ARG A 1 153 ? 28.27272 27.11211  22.40721  0.512 16.78773  ? 148 ARG A NE   1 
ATOM   2336 N NE   B ARG A 1 153 ? 24.42159 25.49858  23.00884  0.488 13.43343  ? 148 ARG A NE   1 
ATOM   2337 C CZ   A ARG A 1 153 ? 28.63273 28.25855  21.83821  0.512 13.43530  ? 148 ARG A CZ   1 
ATOM   2338 C CZ   B ARG A 1 153 ? 24.05697 24.50940  23.81295  0.488 7.76114   ? 148 ARG A CZ   1 
ATOM   2339 N NH1  A ARG A 1 153 ? 27.74770 29.06065  21.25272  0.512 8.74683   ? 148 ARG A NH1  1 
ATOM   2340 N NH1  B ARG A 1 153 ? 24.94532 23.73224  24.41801  0.488 3.28535   ? 148 ARG A NH1  1 
ATOM   2341 N NH2  A ARG A 1 153 ? 29.91650 28.60424  21.83615  0.512 19.10330  ? 148 ARG A NH2  1 
ATOM   2342 N NH2  B ARG A 1 153 ? 22.76434 24.28188  23.99882  0.488 21.51869  ? 148 ARG A NH2  1 
ATOM   2343 H H    B ARG A 1 153 ? 28.00522 23.20996  19.20231  0.488 20.27189  ? 148 ARG A H    1 
ATOM   2344 H HA   A ARG A 1 153 ? 25.95625 24.68087  18.69654  0.512 15.25257  ? 148 ARG A HA   1 
ATOM   2345 H HA   B ARG A 1 153 ? 25.95566 24.67176  18.60630  0.488 18.03434  ? 148 ARG A HA   1 
ATOM   2346 H HB2  A ARG A 1 153 ? 26.46973 24.17501  20.88535  0.512 25.82270  ? 148 ARG A HB2  1 
ATOM   2347 H HB2  B ARG A 1 153 ? 26.49587 24.01591  20.80621  0.488 25.83006  ? 148 ARG A HB2  1 
ATOM   2348 H HB3  A ARG A 1 153 ? 27.86371 24.92944  20.77099  0.512 25.82270  ? 148 ARG A HB3  1 
ATOM   2349 H HB3  B ARG A 1 153 ? 27.70221 25.05033  20.79416  0.488 25.83006  ? 148 ARG A HB3  1 
ATOM   2350 H HG2  A ARG A 1 153 ? 26.42616 26.96677  20.49586  0.512 22.32125  ? 148 ARG A HG2  1 
ATOM   2351 H HG2  B ARG A 1 153 ? 26.23701 26.83645  20.86683  0.488 20.75079  ? 148 ARG A HG2  1 
ATOM   2352 H HG3  A ARG A 1 153 ? 25.33411 26.07436  21.22828  0.512 22.32125  ? 148 ARG A HG3  1 
ATOM   2353 H HG3  B ARG A 1 153 ? 24.98927 25.86699  20.69741  0.488 20.75079  ? 148 ARG A HG3  1 
ATOM   2354 H HD2  A ARG A 1 153 ? 26.35121 27.29756  22.88640  0.512 21.49786  ? 148 ARG A HD2  1 
ATOM   2355 H HD2  B ARG A 1 153 ? 26.36764 25.08644  22.89278  0.488 20.80901  ? 148 ARG A HD2  1 
ATOM   2356 H HD3  A ARG A 1 153 ? 26.90589 25.81718  23.04839  0.512 21.49786  ? 148 ARG A HD3  1 
ATOM   2357 H HD3  B ARG A 1 153 ? 26.05550 26.63897  23.02558  0.488 20.80901  ? 148 ARG A HD3  1 
ATOM   2358 H HE   A ARG A 1 153 ? 28.89323 26.63074  22.75769  0.512 20.16767  ? 148 ARG A HE   1 
ATOM   2359 H HE   B ARG A 1 153 ? 23.79710 26.00247  22.69947  0.488 16.14252  ? 148 ARG A HE   1 
ATOM   2360 H HH11 A ARG A 1 153 ? 26.91590 28.84297  21.23492  0.512 10.51859  ? 148 ARG A HH11 1 
ATOM   2361 H HH11 B ARG A 1 153 ? 25.78621 23.86287  24.29380  0.488 3.96482   ? 148 ARG A HH11 1 
ATOM   2362 H HH12 A ARG A 1 153 ? 28.00732 29.79691  20.89199  0.512 10.51859  ? 148 ARG A HH12 1 
ATOM   2363 H HH12 B ARG A 1 153 ? 24.68042 23.09771  24.93453  0.488 3.96482   ? 148 ARG A HH12 1 
ATOM   2364 H HH21 A ARG A 1 153 ? 30.50119 28.08885  22.19962  0.512 22.94636  ? 148 ARG A HH21 1 
ATOM   2365 H HH21 B ARG A 1 153 ? 22.17997 24.77177  23.60117  0.488 25.84483  ? 148 ARG A HH21 1 
ATOM   2366 H HH22 A ARG A 1 153 ? 30.16224 29.34325  21.47134  0.512 22.94636  ? 148 ARG A HH22 1 
ATOM   2367 H HH22 B ARG A 1 153 ? 22.51009 23.64439  24.51706  0.488 25.84483  ? 148 ARG A HH22 1 
ATOM   2368 N N    . SER A 1 154 ? 28.70978 26.31454  18.44614  1.000 14.44398  ? 149 SER A N    1 
ATOM   2369 C CA   . SER A 1 154 ? 29.27910 27.56097  17.94735  1.000 18.52371  ? 149 SER A CA   1 
ATOM   2370 C C    . SER A 1 154 ? 29.03182 27.72361  16.44929  1.000 18.64491  ? 149 SER A C    1 
ATOM   2371 O O    . SER A 1 154 ? 28.56152 28.77595  16.00873  1.000 11.46179  ? 149 SER A O    1 
ATOM   2372 C CB   . SER A 1 154 ? 30.76655 27.61102  18.30560  1.000 10.61303  ? 149 SER A CB   1 
ATOM   2373 O OG   . SER A 1 154 ? 31.19766 28.94640  18.44632  1.000 58.37346  ? 149 SER A OG   1 
ATOM   2374 H H    . SER A 1 154 ? 29.27483 25.77808  18.81018  1.000 17.35518  ? 149 SER A H    1 
ATOM   2375 H HA   . SER A 1 154 ? 28.84983 28.31688  18.37773  1.000 22.25086  ? 149 SER A HA   1 
ATOM   2376 H HB2  . SER A 1 154 ? 30.90657 27.14289  19.14355  1.000 12.75804  ? 149 SER A HB2  1 
ATOM   2377 H HB3  . SER A 1 154 ? 31.27716 27.18604  17.59881  1.000 12.75804  ? 149 SER A HB3  1 
ATOM   2378 H HG   . SER A 1 154 ? 32.02156 28.96671  18.60877  1.000 70.07055  ? 149 SER A HG   1 
ATOM   2379 N N    . ALA A 1 155 ? 29.30025 26.67390  15.65548  1.000 21.95714  ? 150 ALA A N    1 
ATOM   2380 C CA   . ALA A 1 155 ? 29.10799 26.76490  14.20197  1.000 33.70973  ? 150 ALA A CA   1 
ATOM   2381 C C    . ALA A 1 155 ? 27.65164 26.98726  13.84475  1.000 26.44532  ? 150 ALA A C    1 
ATOM   2382 O O    . ALA A 1 155 ? 27.33658 27.78268  12.94973  1.000 21.10881  ? 150 ALA A O    1 
ATOM   2383 C CB   . ALA A 1 155 ? 29.58515 25.50313  13.48981  1.000 18.98495  ? 150 ALA A CB   1 
ATOM   2384 H H    . ALA A 1 155 ? 29.58955 25.91179  15.92952  1.000 26.37097  ? 150 ALA A H    1 
ATOM   2385 H HA   . ALA A 1 155 ? 29.64266 27.51501  13.89809  1.000 40.47407  ? 150 ALA A HA   1 
ATOM   2386 H HB1  . ALA A 1 155 ? 30.53448 25.38844  13.65266  1.000 22.80434  ? 150 ALA A HB1  1 
ATOM   2387 H HB2  . ALA A 1 155 ? 29.09563 24.74071  13.83621  1.000 22.80434  ? 150 ALA A HB2  1 
ATOM   2388 H HB3  . ALA A 1 155 ? 29.42168 25.59660  12.53826  1.000 22.80434  ? 150 ALA A HB3  1 
ATOM   2389 N N    . TYR A 1 156 ? 26.75081 26.28902  14.53898  1.000 17.92583  ? 151 TYR A N    1 
ATOM   2390 C CA   . TYR A 1 156 ? 25.32249 26.49361  14.32370  1.000 14.86090  ? 151 TYR A CA   1 
ATOM   2391 C C    . TYR A 1 156 ? 24.89804 27.95662  14.55882  1.000 27.68487  ? 151 TYR A C    1 
ATOM   2392 O O    . TYR A 1 156 ? 24.16755 28.53420  13.74053  1.000 16.78616  ? 151 TYR A O    1 
ATOM   2393 C CB   . TYR A 1 156 ? 24.56215 25.54009  15.21859  1.000 7.16660   ? 151 TYR A CB   1 
ATOM   2394 C CG   . TYR A 1 156 ? 24.31899 24.15739  14.64334  1.000 19.64184  ? 151 TYR A CG   1 
ATOM   2395 C CD1  . TYR A 1 156 ? 24.05335 23.98565  13.29905  1.000 12.16482  ? 151 TYR A CD1  1 
ATOM   2396 C CD2  . TYR A 1 156 ? 24.27787 23.03113  15.46261  1.000 9.52669   ? 151 TYR A CD2  1 
ATOM   2397 C CE1  . TYR A 1 156 ? 23.80975 22.75003  12.77828  1.000 15.60117  ? 151 TYR A CE1  1 
ATOM   2398 C CE2  . TYR A 1 156 ? 24.03041 21.76263  14.93703  1.000 10.06088  ? 151 TYR A CE2  1 
ATOM   2399 C CZ   . TYR A 1 156 ? 23.79348 21.64115  13.58058  1.000 20.27841  ? 151 TYR A CZ   1 
ATOM   2400 O OH   . TYR A 1 156 ? 23.49438 20.43417  12.98141  1.000 14.57116  ? 151 TYR A OH   1 
ATOM   2401 H H    . TYR A 1 156 ? 26.94020 25.69748  15.13380  1.000 21.53339  ? 151 TYR A H    1 
ATOM   2402 H HA   . TYR A 1 156 ? 25.10506 26.29845  13.39874  1.000 17.85549  ? 151 TYR A HA   1 
ATOM   2403 H HB2  . TYR A 1 156 ? 25.06496 25.42643  16.04028  1.000 8.62232   ? 151 TYR A HB2  1 
ATOM   2404 H HB3  . TYR A 1 156 ? 23.69472 25.92898  15.41154  1.000 8.62232   ? 151 TYR A HB3  1 
ATOM   2405 H HD1  . TYR A 1 156 ? 24.04044 24.72750  12.73834  1.000 14.62019  ? 151 TYR A HD1  1 
ATOM   2406 H HD2  . TYR A 1 156 ? 24.41802 23.12674  16.37701  1.000 11.45443  ? 151 TYR A HD2  1 
ATOM   2407 H HE1  . TYR A 1 156 ? 23.65258 22.65910  11.86618  1.000 18.74381  ? 151 TYR A HE1  1 
ATOM   2408 H HE2  . TYR A 1 156 ? 24.02496 21.01367  15.48834  1.000 12.09545  ? 151 TYR A HE2  1 
ATOM   2409 H HH   . TYR A 1 156 ? 22.82726 20.52066  12.47835  1.000 17.50780  ? 151 TYR A HH   1 
ATOM   2410 N N    . GLN A 1 157 ? 25.35512 28.58327  15.65874  1.000 31.89044  ? 152 GLN A N    1 
ATOM   2411 C CA   . GLN A 1 157 ? 24.90451 29.93689  16.01658  1.000 17.68249  ? 152 GLN A CA   1 
ATOM   2412 C C    . GLN A 1 157 ? 25.42198 31.01299  15.05745  1.000 15.50408  ? 152 GLN A C    1 
ATOM   2413 O O    . GLN A 1 157 ? 24.72150 31.99673  14.79297  1.000 20.86043  ? 152 GLN A O    1 
ATOM   2414 C CB   . GLN A 1 157 ? 25.37471 30.29676  17.43217  1.000 16.12679  ? 152 GLN A CB   1 
ATOM   2415 C CG   . GLN A 1 157 ? 24.86353 31.64351  17.95275  1.000 23.61591  ? 152 GLN A CG   1 
ATOM   2416 C CD   . GLN A 1 157 ? 23.45992 31.49767  18.45468  1.000 40.65743  ? 152 GLN A CD   1 
ATOM   2417 O OE1  . GLN A 1 157 ? 22.50730 32.00542  17.83854  1.000 19.15154  ? 152 GLN A OE1  1 
ATOM   2418 N NE2  . GLN A 1 157 ? 23.30546 30.73536  19.55180  1.000 28.60573  ? 152 GLN A NE2  1 
ATOM   2419 H H    . GLN A 1 157 ? 25.92315 28.24738  16.21021  1.000 38.29093  ? 152 GLN A H    1 
ATOM   2420 H HA   . GLN A 1 157 ? 23.93540 29.92536  15.97657  1.000 21.24139  ? 152 GLN A HA   1 
ATOM   2421 H HB2  . GLN A 1 157 ? 25.06489 29.61046  18.04364  1.000 19.37455  ? 152 GLN A HB2  1 
ATOM   2422 H HB3  . GLN A 1 157 ? 26.34410 30.33107  17.43555  1.000 19.37455  ? 152 GLN A HB3  1 
ATOM   2423 H HG2  . GLN A 1 157 ? 25.42580 31.94646  18.68280  1.000 28.36149  ? 152 GLN A HG2  1 
ATOM   2424 H HG3  . GLN A 1 157 ? 24.87174 32.29584  17.23492  1.000 28.36149  ? 152 GLN A HG3  1 
ATOM   2425 H HE21 . GLN A 1 157 ? 23.99025 30.36757  19.91975  1.000 34.34927  ? 152 GLN A HE21 1 
ATOM   2426 H HE22 . GLN A 1 157 ? 22.52190 30.61568  19.88542  1.000 34.34927  ? 152 GLN A HE22 1 
ATOM   2427 N N    . GLU A 1 158 ? 26.66243 30.88675  14.57030  1.000 15.56365  ? 153 GLU A N    1 
ATOM   2428 C CA   . GLU A 1 158 ? 27.18158 31.89891  13.64249  1.000 22.25408  ? 153 GLU A CA   1 
ATOM   2429 C C    . GLU A 1 158 ? 26.36114 31.92851  12.35522  1.000 37.23193  ? 153 GLU A C    1 
ATOM   2430 O O    . GLU A 1 158 ? 26.11811 33.00643  11.78225  1.000 22.38089  ? 153 GLU A O    1 
ATOM   2431 C CB   . GLU A 1 158 ? 28.65860 31.63403  13.30791  1.000 15.15630  ? 153 GLU A CB   1 
ATOM   2432 C CG   . GLU A 1 158 ? 29.29026 32.69359  12.41645  1.000 54.38869  ? 153 GLU A CG   1 
ATOM   2433 C CD   . GLU A 1 158 ? 30.80020 32.50572  12.24712  1.000 57.48744  ? 153 GLU A CD   1 
ATOM   2434 O OE1  . GLU A 1 158 ? 31.33836 31.53135  12.81865  1.000 43.14457  ? 153 GLU A OE1  1 
ATOM   2435 O OE2  . GLU A 1 158 ? 31.44251 33.33046  11.54139  1.000 50.78440  ? 153 GLU A OE2  1 
ATOM   2436 H H    . GLU A 1 158 ? 27.20607 30.24634  14.75451  1.000 18.69878  ? 153 GLU A H    1 
ATOM   2437 H HA   . GLU A 1 158 ? 27.12480 32.76377  14.07804  1.000 26.72729  ? 153 GLU A HA   1 
ATOM   2438 H HB2  . GLU A 1 158 ? 29.16435 31.60440  14.13509  1.000 18.20996  ? 153 GLU A HB2  1 
ATOM   2439 H HB3  . GLU A 1 158 ? 28.72535 30.78284  12.84756  1.000 18.20996  ? 153 GLU A HB3  1 
ATOM   2440 H HG2  . GLU A 1 158 ? 28.88267 32.65031  11.53730  1.000 65.28883  ? 153 GLU A HG2  1 
ATOM   2441 H HG3  . GLU A 1 158 ? 29.13944 33.56751  12.80940  1.000 65.28883  ? 153 GLU A HG3  1 
ATOM   2442 N N    . ALA A 1 159 ? 25.93892 30.74134  11.88845  1.000 14.37978  ? 154 ALA A N    1 
ATOM   2443 C CA   . ALA A 1 159 ? 25.13332 30.63994  10.68137  1.000 16.83418  ? 154 ALA A CA   1 
ATOM   2444 C C    . ALA A 1 159 ? 23.74269 31.20803  10.88867  1.000 13.22532  ? 154 ALA A C    1 
ATOM   2445 O O    . ALA A 1 159 ? 23.16775 31.79731  9.96765   1.000 23.57916  ? 154 ALA A O    1 
ATOM   2446 C CB   . ALA A 1 159 ? 25.03691 29.17754  10.24303  1.000 16.65639  ? 154 ALA A CB   1 
ATOM   2447 H H    . ALA A 1 159 ? 26.10972 29.98395  12.25830  1.000 17.27814  ? 154 ALA A H    1 
ATOM   2448 H HA   . ALA A 1 159 ? 25.56736 31.14931  9.97919   1.000 20.22342  ? 154 ALA A HA   1 
ATOM   2449 H HB1  . ALA A 1 159 ? 25.89787 28.89395  9.89772   1.000 20.01007  ? 154 ALA A HB1  1 
ATOM   2450 H HB2  . ALA A 1 159 ? 24.79210 28.63399  11.00822  1.000 20.01007  ? 154 ALA A HB2  1 
ATOM   2451 H HB3  . ALA A 1 159 ? 24.36107 29.09898  9.55168   1.000 20.01007  ? 154 ALA A HB3  1 
ATOM   2452 N N    . MET A 1 160 ? 23.18165 31.03487  12.09066  1.000 28.96738  ? 155 MET A N    1 
ATOM   2453 C CA   . MET A 1 160 ? 21.87703 31.61988  12.38723  1.000 15.62073  ? 155 MET A CA   1 
ATOM   2454 C C    . MET A 1 160 ? 21.96185 33.13595  12.28149  1.000 20.70522  ? 155 MET A C    1 
ATOM   2455 O O    . MET A 1 160 ? 21.12662 33.76796  11.62361  1.000 26.98311  ? 155 MET A O    1 
ATOM   2456 C CB   . MET A 1 160 ? 21.38781 31.22797  13.78976  1.000 31.09311  ? 155 MET A CB   1 
ATOM   2457 C CG   . MET A 1 160 ? 20.57090 29.88416  14.01693  1.000 39.21129  ? 155 MET A CG   1 
ATOM   2458 S SD   . MET A 1 160 ? 19.18654 29.31903  12.98053  1.000 25.36447  ? 155 MET A SD   1 
ATOM   2459 C CE   . MET A 1 160 ? 17.89630 30.43198  13.49021  1.000 37.13020  ? 155 MET A CE   1 
ATOM   2460 H H    . MET A 1 160 ? 23.53156 30.59044  12.73845  1.000 34.78326  ? 155 MET A H    1 
ATOM   2461 H HA   . MET A 1 160 ? 21.23550 31.26260  11.75344  1.000 18.76727  ? 155 MET A HA   1 
ATOM   2462 H HB2  . MET A 1 160 ? 22.17217 31.16154  14.35657  1.000 37.33414  ? 155 MET A HB2  1 
ATOM   2463 H HB3  . MET A 1 160 ? 20.81309 31.94459  14.10131  1.000 37.33414  ? 155 MET A HB3  1 
ATOM   2464 H HG2  . MET A 1 160 ? 21.22040 29.16501  13.97377  1.000 47.07595  ? 155 MET A HG2  1 
ATOM   2465 H HG3  . MET A 1 160 ? 20.20058 29.94349  14.91150  1.000 47.07595  ? 155 MET A HG3  1 
ATOM   2466 H HE1  . MET A 1 160 ? 17.09745 30.24801  12.97164  1.000 44.57864  ? 155 MET A HE1  1 
ATOM   2467 H HE2  . MET A 1 160 ? 17.71670 30.29634  14.43373  1.000 44.57864  ? 155 MET A HE2  1 
ATOM   2468 H HE3  . MET A 1 160 ? 18.18744 31.34444  13.33674  1.000 44.57864  ? 155 MET A HE3  1 
ATOM   2469 N N    . ASP A 1 161 ? 22.97664 33.74301  12.91719  1.000 23.01932  ? 156 ASP A N    1 
ATOM   2470 C CA   . ASP A 1 161 ? 23.06177 35.21298  12.94606  1.000 23.11799  ? 156 ASP A CA   1 
ATOM   2471 C C    . ASP A 1 161 ? 23.12067 35.79784  11.52736  1.000 27.70051  ? 156 ASP A C    1 
ATOM   2472 O O    . ASP A 1 161 ? 22.40649 36.75869  11.21512  1.000 18.28210  ? 156 ASP A O    1 
ATOM   2473 C CB   . ASP A 1 161 ? 24.27225 35.67611  13.77753  1.000 24.95177  ? 156 ASP A CB   1 
ATOM   2474 C CG   . ASP A 1 161 ? 24.20180 35.22184  15.25190  1.000 22.52684  ? 156 ASP A CG   1 
ATOM   2475 O OD1  . ASP A 1 161 ? 23.07678 34.95400  15.72788  1.000 29.48390  ? 156 ASP A OD1  1 
ATOM   2476 O OD2  . ASP A 1 161 ? 25.26454 35.13050  15.93350  1.000 20.83732  ? 156 ASP A OD2  1 
ATOM   2477 H H    . ASP A 1 161 ? 23.61325 33.33769  13.32955  1.000 27.64559  ? 156 ASP A H    1 
ATOM   2478 H HA   . ASP A 1 161 ? 22.26279 35.55170  13.37942  1.000 27.76399  ? 156 ASP A HA   1 
ATOM   2479 H HB2  . ASP A 1 161 ? 25.08090 35.30685  13.38941  1.000 29.96453  ? 156 ASP A HB2  1 
ATOM   2480 H HB3  . ASP A 1 161 ? 24.31084 36.64526  13.76500  1.000 29.96453  ? 156 ASP A HB3  1 
ATOM   2481 N N    . ILE A 1 162 ? 23.95847 35.21091  10.64460  1.000 15.32709  ? 157 ILE A N    1 
ATOM   2482 C CA   . ILE A 1 162 ? 23.99553 35.60377  9.22918   1.000 17.29319  ? 157 ILE A CA   1 
ATOM   2483 C C    . ILE A 1 162 ? 22.63675 35.39445  8.55516   1.000 15.22215  ? 157 ILE A C    1 
ATOM   2484 O O    . ILE A 1 162 ? 22.10971 36.29999  7.89979   1.000 16.55927  ? 157 ILE A O    1 
ATOM   2485 C CB   . ILE A 1 162 ? 25.09026 34.83245  8.46529   1.000 28.61950  ? 157 ILE A CB   1 
ATOM   2486 C CG1  . ILE A 1 162 ? 26.46538 35.03586  9.07930   1.000 14.84046  ? 157 ILE A CG1  1 
ATOM   2487 C CG2  . ILE A 1 162 ? 25.16621 35.29698  6.97314   1.000 21.91347  ? 157 ILE A CG2  1 
ATOM   2488 C CD1  . ILE A 1 162 ? 27.58135 34.17287  8.44371   1.000 24.10437  ? 157 ILE A CD1  1 
ATOM   2489 H H    . ILE A 1 162 ? 24.51248 34.58428  10.84464  1.000 18.41490  ? 157 ILE A H    1 
ATOM   2490 H HA   . ILE A 1 162 ? 24.20648 36.55032  9.20785   1.000 20.77423  ? 157 ILE A HA   1 
ATOM   2491 H HB   . ILE A 1 162 ? 24.84349 33.89609  8.52217   1.000 34.36580  ? 157 ILE A HB   1 
ATOM   2492 H HG12 . ILE A 1 162 ? 26.71741 35.96649  8.97294   1.000 17.83095  ? 157 ILE A HG12 1 
ATOM   2493 H HG13 . ILE A 1 162 ? 26.42027 34.80997  10.02155  1.000 17.83095  ? 157 ILE A HG13 1 
ATOM   2494 H HG21 . ILE A 1 162 ? 24.28434 35.22688  6.57529   1.000 26.31857  ? 157 ILE A HG21 1 
ATOM   2495 H HG22 . ILE A 1 162 ? 25.46996 36.21774  6.94411   1.000 26.31857  ? 157 ILE A HG22 1 
ATOM   2496 H HG23 . ILE A 1 162 ? 25.79033 34.72760  6.49651   1.000 26.31857  ? 157 ILE A HG23 1 
ATOM   2497 H HD11 . ILE A 1 162 ? 27.30031 33.24448  8.44202   1.000 28.94764  ? 157 ILE A HD11 1 
ATOM   2498 H HD12 . ILE A 1 162 ? 27.73407 34.47390  7.53434   1.000 28.94764  ? 157 ILE A HD12 1 
ATOM   2499 H HD13 . ILE A 1 162 ? 28.39297 34.27183  8.96561   1.000 28.94764  ? 157 ILE A HD13 1 
ATOM   2500 N N    . SER A 1 163 ? 22.06644 34.18867  8.66825   1.000 12.92797  ? 158 SER A N    1 
ATOM   2501 C CA   . SER A 1 163 ? 20.80502 33.92938  7.97725   1.000 15.37589  ? 158 SER A CA   1 
ATOM   2502 C C    . SER A 1 163 ? 19.70740 34.89682  8.41644   1.000 21.63028  ? 158 SER A C    1 
ATOM   2503 O O    . SER A 1 163 ? 18.90141 35.33584  7.58703   1.000 32.37667  ? 158 SER A O    1 
ATOM   2504 C CB   . SER A 1 163 ? 20.37448 32.46828  8.15437   1.000 15.22277  ? 158 SER A CB   1 
ATOM   2505 O OG   . SER A 1 163 ? 19.78754 32.20162  9.39945   1.000 18.68072  ? 158 SER A OG   1 
ATOM   2506 H H    . SER A 1 163 ? 22.37986 33.52935  9.12286   1.000 15.53596  ? 158 SER A H    1 
ATOM   2507 H HA   . SER A 1 163 ? 20.94593 34.06848  7.02767   1.000 18.47346  ? 158 SER A HA   1 
ATOM   2508 H HB2  . SER A 1 163 ? 19.72964 32.25487  7.46189   1.000 18.28973  ? 158 SER A HB2  1 
ATOM   2509 H HB3  . SER A 1 163 ? 21.15952 31.90618  8.06127   1.000 18.28973  ? 158 SER A HB3  1 
ATOM   2510 H HG   . SER A 1 163 ? 20.38050 32.00056  9.95943   1.000 22.43926  ? 158 SER A HG   1 
ATOM   2511 N N    . LYS A 1 164 ? 19.66111 35.24880  9.70185   1.000 14.70225  ? 159 LYS A N    1 
ATOM   2512 C CA   . LYS A 1 164 ? 18.60608 36.13868  10.17870  1.000 18.25347  ? 159 LYS A CA   1 
ATOM   2513 C C    . LYS A 1 164 ? 18.73311 37.52689  9.56572   1.000 19.57078  ? 159 LYS A C    1 
ATOM   2514 O O    . LYS A 1 164 ? 17.74496 38.10007  9.10091   1.000 21.69108  ? 159 LYS A O    1 
ATOM   2515 C CB   . LYS A 1 164 ? 18.62080 36.23697  11.71121  1.000 23.96838  ? 159 LYS A CB   1 
ATOM   2516 H H    . LYS A 1 164 ? 20.21719 34.99129  10.30522  1.000 17.66510  ? 159 LYS A H    1 
ATOM   2517 H HA   . LYS A 1 164 ? 17.75473 35.75797  9.91192   1.000 21.92657  ? 159 LYS A HA   1 
ATOM   2518 N N    . LYS A 1 165 ? 19.93622 38.09047  9.55257   1.000 15.03738  ? 160 LYS A N    1 
ATOM   2519 C CA   . LYS A 1 165 ? 20.07510 39.41426  8.97759   1.000 18.79499  ? 160 LYS A CA   1 
ATOM   2520 C C    . LYS A 1 165 ? 20.24981 39.44132  7.45733   1.000 28.15072  ? 160 LYS A C    1 
ATOM   2521 O O    . LYS A 1 165 ? 20.22679 40.52945  6.89579   1.000 27.75514  ? 160 LYS A O    1 
ATOM   2522 C CB   . LYS A 1 165 ? 21.25067 40.14752  9.63341   1.000 14.41201  ? 160 LYS A CB   1 
ATOM   2523 C CG   . LYS A 1 165 ? 22.57786 39.52779  9.41686   1.000 49.15599  ? 160 LYS A CG   1 
ATOM   2524 C CD   . LYS A 1 165 ? 23.47199 39.74481  10.64103  1.000 48.29425  ? 160 LYS A CD   1 
ATOM   2525 C CE   . LYS A 1 165 ? 23.51147 41.17607  10.98296  1.000 40.95581  ? 160 LYS A CE   1 
ATOM   2526 N NZ   . LYS A 1 165 ? 23.54030 42.00129  9.73693   1.000 52.20386  ? 160 LYS A NZ   1 
ATOM   2527 H H    . LYS A 1 165 ? 20.65760 37.73704  9.85965   1.000 18.06725  ? 160 LYS A H    1 
ATOM   2528 H HA   . LYS A 1 165 ? 19.25611 39.89733  9.16942   1.000 22.57639  ? 160 LYS A HA   1 
ATOM   2529 H HB2  . LYS A 1 165 ? 21.28876 41.04796  9.27471   1.000 17.31682  ? 160 LYS A HB2  1 
ATOM   2530 H HB3  . LYS A 1 165 ? 21.09725 40.17797  10.59071  1.000 17.31682  ? 160 LYS A HB3  1 
ATOM   2531 H HG2  . LYS A 1 165 ? 22.47285 38.57398  9.27505   1.000 59.00959  ? 160 LYS A HG2  1 
ATOM   2532 H HG3  . LYS A 1 165 ? 23.00468 39.93284  8.64571   1.000 59.00959  ? 160 LYS A HG3  1 
ATOM   2533 H HD2  . LYS A 1 165 ? 23.11646 39.25306  11.39779  1.000 57.97550  ? 160 LYS A HD2  1 
ATOM   2534 H HD3  . LYS A 1 165 ? 24.37379 39.44594  10.44525  1.000 57.97550  ? 160 LYS A HD3  1 
ATOM   2535 H HE2  . LYS A 1 165 ? 22.72114 41.41162  11.49365  1.000 49.16938  ? 160 LYS A HE2  1 
ATOM   2536 H HE3  . LYS A 1 165 ? 24.30963 41.36621  11.50033  1.000 49.16938  ? 160 LYS A HE3  1 
ATOM   2537 H HZ1  . LYS A 1 165 ? 23.96232 42.76969  9.89042   1.000 62.66704  ? 160 LYS A HZ1  1 
ATOM   2538 H HZ2  . LYS A 1 165 ? 23.96619 41.56194  9.09064   1.000 62.66704  ? 160 LYS A HZ2  1 
ATOM   2539 H HZ3  . LYS A 1 165 ? 22.71000 42.17638  9.46851   1.000 62.66704  ? 160 LYS A HZ3  1 
ATOM   2540 N N    . GLU A 1 166 ? 20.39588 38.30615  6.75530   1.000 31.06094  ? 161 GLU A N    1 
ATOM   2541 C CA   . GLU A 1 166 ? 20.73441 38.39259  5.33546   1.000 30.79189  ? 161 GLU A CA   1 
ATOM   2542 C C    . GLU A 1 166 ? 19.81908 37.63096  4.37388   1.000 26.27440  ? 161 GLU A C    1 
ATOM   2543 O O    . GLU A 1 166 ? 20.07124 37.66856  3.16612   1.000 21.60909  ? 161 GLU A O    1 
ATOM   2544 C CB   . GLU A 1 166 ? 22.18352 37.89860  5.08756   1.000 39.14948  ? 161 GLU A CB   1 
ATOM   2545 C CG   . GLU A 1 166 ? 23.32144 38.75532  5.63731   1.000 33.45215  ? 161 GLU A CG   1 
ATOM   2546 C CD   . GLU A 1 166 ? 23.38778 40.14127  5.05444   1.000 43.34839  ? 161 GLU A CD   1 
ATOM   2547 O OE1  . GLU A 1 166 ? 22.68343 40.42732  4.05683   1.000 57.25932  ? 161 GLU A OE1  1 
ATOM   2548 O OE2  . GLU A 1 166 ? 24.16106 40.95336  5.60826   1.000 53.14485  ? 161 GLU A OE2  1 
ATOM   2549 H H    . GLU A 1 166 ? 20.30678 37.51080  7.07006   1.000 37.29552  ? 161 GLU A H    1 
ATOM   2550 H HA   . GLU A 1 166 ? 20.66313 39.33244  5.10634   1.000 36.97266  ? 161 GLU A HA   1 
ATOM   2551 H HB2  . GLU A 1 166 ? 22.27220 37.02143  5.49206   1.000 47.00178  ? 161 GLU A HB2  1 
ATOM   2552 H HB3  . GLU A 1 166 ? 22.31694 37.83682  4.12877   1.000 47.00178  ? 161 GLU A HB3  1 
ATOM   2553 H HG2  . GLU A 1 166 ? 23.20704 38.84517  6.59634   1.000 40.16498  ? 161 GLU A HG2  1 
ATOM   2554 H HG3  . GLU A 1 166 ? 24.16350 38.31456  5.44350   1.000 40.16498  ? 161 GLU A HG3  1 
ATOM   2555 N N    . MET A 1 167 ? 18.81337 36.90175  4.86126   1.000 21.62541  ? 162 MET A N    1 
ATOM   2556 C CA   . MET A 1 167 ? 17.97132 36.12309  3.96262   1.000 17.31733  ? 162 MET A CA   1 
ATOM   2557 C C    . MET A 1 167 ? 16.56329 36.12000  4.49345   1.000 30.92470  ? 162 MET A C    1 
ATOM   2558 O O    . MET A 1 167 ? 16.34764 36.31678  5.71115   1.000 21.92584  ? 162 MET A O    1 
ATOM   2559 C CB   . MET A 1 167 ? 18.42213 34.66076  3.79729   1.000 31.35271  ? 162 MET A CB   1 
ATOM   2560 C CG   . MET A 1 167 ? 19.91049 34.34074  3.76329   1.000 33.43318  ? 162 MET A CG   1 
ATOM   2561 S SD   . MET A 1 167 ? 20.07358 32.62894  4.28044   1.000 31.03998  ? 162 MET A SD   1 
ATOM   2562 C CE   . MET A 1 167 ? 21.39928 32.09672  3.26576   1.000 33.64794  ? 162 MET A CE   1 
ATOM   2563 H H    . MET A 1 167 ? 18.60576 36.84541  5.69392   1.000 25.97289  ? 162 MET A H    1 
ATOM   2564 H HA   . MET A 1 167 ? 18.01920 36.55512  3.09546   1.000 20.80319  ? 162 MET A HA   1 
ATOM   2565 H HB2  . MET A 1 167 ? 18.05213 34.15724  4.53922   1.000 37.64565  ? 162 MET A HB2  1 
ATOM   2566 H HB3  . MET A 1 167 ? 18.05460 34.33652  2.96022   1.000 37.64565  ? 162 MET A HB3  1 
ATOM   2567 H HG2  . MET A 1 167 ? 20.26023 34.44479  2.86454   1.000 40.14222  ? 162 MET A HG2  1 
ATOM   2568 H HG3  . MET A 1 167 ? 20.39577 34.91452  4.37662   1.000 40.14222  ? 162 MET A HG3  1 
ATOM   2569 H HE1  . MET A 1 167 ? 21.61446 31.17647  3.48423   1.000 40.39993  ? 162 MET A HE1  1 
ATOM   2570 H HE2  . MET A 1 167 ? 21.13111 32.16191  2.33585   1.000 40.39993  ? 162 MET A HE2  1 
ATOM   2571 H HE3  . MET A 1 167 ? 22.16906 32.66403  3.42857   1.000 40.39993  ? 162 MET A HE3  1 
ATOM   2572 N N    . PRO A 1 168 ? 15.56902 35.84563  3.64727   1.000 24.58860  ? 163 PRO A N    1 
ATOM   2573 C CA   . PRO A 1 168 ? 14.17999 35.88931  4.05819   1.000 14.01726  ? 163 PRO A CA   1 
ATOM   2574 C C    . PRO A 1 168 ? 13.78323 34.64396  4.81928   1.000 25.04559  ? 163 PRO A C    1 
ATOM   2575 O O    . PRO A 1 168 ? 14.42072 33.58814  4.65904   1.000 15.29901  ? 163 PRO A O    1 
ATOM   2576 C CB   . PRO A 1 168 ? 13.42224 35.97334  2.73157   1.000 10.75281  ? 163 PRO A CB   1 
ATOM   2577 C CG   . PRO A 1 168 ? 14.25875 35.19190  1.78938   1.000 15.21313  ? 163 PRO A CG   1 
ATOM   2578 C CD   . PRO A 1 168 ? 15.68849 35.56725  2.19510   1.000 40.92825  ? 163 PRO A CD   1 
ATOM   2579 H HA   . PRO A 1 168 ? 14.01132 36.67639  4.59945   1.000 16.84311  ? 163 PRO A HA   1 
ATOM   2580 H HB2  . PRO A 1 168 ? 12.54006 35.58109  2.82538   1.000 12.92578  ? 163 PRO A HB2  1 
ATOM   2581 H HB3  . PRO A 1 168 ? 13.34581 36.89798  2.44855   1.000 12.92578  ? 163 PRO A HB3  1 
ATOM   2582 H HG2  . PRO A 1 168 ? 14.09747 34.24211  1.90250   1.000 18.27816  ? 163 PRO A HG2  1 
ATOM   2583 H HG3  . PRO A 1 168 ? 14.07117 35.45359  0.87437   1.000 18.27816  ? 163 PRO A HG3  1 
ATOM   2584 H HD2  . PRO A 1 168 ? 16.29791 34.83001  2.03390   1.000 49.13630  ? 163 PRO A HD2  1 
ATOM   2585 H HD3  . PRO A 1 168 ? 15.98759 36.35579  1.71588   1.000 49.13630  ? 163 PRO A HD3  1 
ATOM   2586 N N    . PRO A 1 169 ? 12.68613 34.70713  5.59635   1.000 22.42557  ? 164 PRO A N    1 
ATOM   2587 C CA   . PRO A 1 169 ? 12.32503 33.58878  6.49011   1.000 14.49892  ? 164 PRO A CA   1 
ATOM   2588 C C    . PRO A 1 169 ? 11.85198 32.33481  5.78936   1.000 12.69855  ? 164 PRO A C    1 
ATOM   2589 O O    . PRO A 1 169 ? 11.71432 31.30777  6.46780   1.000 18.91707  ? 164 PRO A O    1 
ATOM   2590 C CB   . PRO A 1 169 ? 11.19643 34.16416  7.35463   1.000 24.96363  ? 164 PRO A CB   1 
ATOM   2591 C CG   . PRO A 1 169 ? 10.91080 35.57804  6.83921   1.000 20.53444  ? 164 PRO A CG   1 
ATOM   2592 C CD   . PRO A 1 169 ? 11.66104 35.77184  5.56392   1.000 24.47382  ? 164 PRO A CD   1 
ATOM   2593 H HA   . PRO A 1 169 ? 13.09336 33.37572  7.04254   1.000 17.42110  ? 164 PRO A HA   1 
ATOM   2594 H HB2  . PRO A 1 169 ? 10.40819 33.60552  7.26791   1.000 29.97875  ? 164 PRO A HB2  1 
ATOM   2595 H HB3  . PRO A 1 169 ? 11.48310 34.19194  8.28088   1.000 29.97875  ? 164 PRO A HB3  1 
ATOM   2596 H HG2  . PRO A 1 169 ? 9.95791  35.67275  6.68450   1.000 24.66373  ? 164 PRO A HG2  1 
ATOM   2597 H HG3  . PRO A 1 169 ? 11.20502 36.22259  7.50170   1.000 24.66373  ? 164 PRO A HG3  1 
ATOM   2598 H HD2  . PRO A 1 169 ? 11.07421 35.66092  4.79956   1.000 29.39099  ? 164 PRO A HD2  1 
ATOM   2599 H HD3  . PRO A 1 169 ? 12.07620 36.64815  5.53903   1.000 29.39099  ? 164 PRO A HD3  1 
ATOM   2600 N N    . THR A 1 170 ? 11.58620 32.39365  4.48260   1.000 12.81797  ? 165 THR A N    1 
ATOM   2601 C CA   . THR A 1 170 ? 11.18724 31.26006  3.65417   1.000 21.32399  ? 165 THR A CA   1 
ATOM   2602 C C    . THR A 1 170 ? 12.33760 30.62521  2.85841   1.000 20.10113  ? 165 THR A C    1 
ATOM   2603 O O    . THR A 1 170 ? 12.12349 29.61244  2.19211   1.000 9.57272   ? 165 THR A O    1 
ATOM   2604 C CB   . THR A 1 170 ? 10.09782 31.72090  2.67082   1.000 16.63845  ? 165 THR A CB   1 
ATOM   2605 O OG1  . THR A 1 170 ? 10.46357 33.00890  2.16746   1.000 39.65669  ? 165 THR A OG1  1 
ATOM   2606 C CG2  . THR A 1 170 ? 8.77240  31.87025  3.35703   1.000 27.26201  ? 165 THR A CG2  1 
ATOM   2607 H H    . THR A 1 170 ? 11.63335 33.12264  4.02878   1.000 15.40397  ? 165 THR A H    1 
ATOM   2608 H HA   . THR A 1 170 ? 10.82990 30.56708  4.23121   1.000 25.61119  ? 165 THR A HA   1 
ATOM   2609 H HB   . THR A 1 170 ? 10.01126 31.06550  1.96100   1.000 19.98854  ? 165 THR A HB   1 
ATOM   2610 H HG1  . THR A 1 170 ? 10.33271 33.59475  2.75504   1.000 47.61043  ? 165 THR A HG1  1 
ATOM   2611 H HG21 . THR A 1 170 ? 8.45242  31.00362  3.65278   1.000 32.73682  ? 165 THR A HG21 1 
ATOM   2612 H HG22 . THR A 1 170 ? 8.86152  32.45266  4.12758   1.000 32.73682  ? 165 THR A HG22 1 
ATOM   2613 H HG23 . THR A 1 170 ? 8.12382  32.25356  2.74604   1.000 32.73682  ? 165 THR A HG23 1 
ATOM   2614 N N    . ASN A 1 171 ? 13.53160 31.18630  2.88678   1.000 14.82042  ? 166 ASN A N    1 
ATOM   2615 C CA   . ASN A 1 171 ? 14.64969 30.56052  2.18846   1.000 27.81520  ? 166 ASN A CA   1 
ATOM   2616 C C    . ASN A 1 171 ? 14.83749 29.11509  2.65394   1.000 24.88245  ? 166 ASN A C    1 
ATOM   2617 O O    . ASN A 1 171 ? 14.90297 28.85476  3.86398   1.000 15.24723  ? 166 ASN A O    1 
ATOM   2618 C CB   . ASN A 1 171 ? 15.91152 31.38698  2.44417   1.000 23.38224  ? 166 ASN A CB   1 
ATOM   2619 C CG   . ASN A 1 171 ? 17.07710 30.96883  1.55779   1.000 34.25103  ? 166 ASN A CG   1 
ATOM   2620 O OD1  . ASN A 1 171 ? 17.17401 29.82011  1.10991   1.000 37.42771  ? 166 ASN A OD1  1 
ATOM   2621 N ND2  . ASN A 1 171 ? 17.96844 31.90005  1.30540   1.000 38.84635  ? 166 ASN A ND2  1 
ATOM   2622 H H    . ASN A 1 171 ? 13.72399 31.91821  3.29530   1.000 17.80691  ? 166 ASN A H    1 
ATOM   2623 H HA   . ASN A 1 171 ? 14.47685 30.52870  1.23452   1.000 33.40064  ? 166 ASN A HA   1 
ATOM   2624 H HB2  . ASN A 1 171 ? 15.71933 32.32102  2.26664   1.000 28.08109  ? 166 ASN A HB2  1 
ATOM   2625 H HB3  . ASN A 1 171 ? 16.18184 31.27382  3.36885   1.000 28.08109  ? 166 ASN A HB3  1 
ATOM   2626 H HD21 . ASN A 1 171 ? 18.64861 31.72138  0.81038   1.000 46.63802  ? 166 ASN A HD21 1 
ATOM   2627 H HD22 . ASN A 1 171 ? 17.87186 32.68841  1.63519   1.000 46.63802  ? 166 ASN A HD22 1 
ATOM   2628 N N    . PRO A 1 172 ? 14.95236 28.13805  1.74728   1.000 14.47142  ? 167 PRO A N    1 
ATOM   2629 C CA   . PRO A 1 172 ? 15.06597 26.75127  2.23049   1.000 27.09142  ? 167 PRO A CA   1 
ATOM   2630 C C    . PRO A 1 172 ? 16.36891 26.44194  2.98224   1.000 19.54238  ? 167 PRO A C    1 
ATOM   2631 O O    . PRO A 1 172 ? 16.36177 25.59551  3.88208   1.000 26.40759  ? 167 PRO A O    1 
ATOM   2632 C CB   . PRO A 1 172 ? 14.92497 25.92800  0.94226   1.000 13.03054  ? 167 PRO A CB   1 
ATOM   2633 C CG   . PRO A 1 172 ? 14.27986 26.82423  -0.02343  1.000 20.13533  ? 167 PRO A CG   1 
ATOM   2634 C CD   . PRO A 1 172 ? 14.87198 28.16429  0.28352   1.000 22.03564  ? 167 PRO A CD   1 
ATOM   2635 H HA   . PRO A 1 172 ? 14.32569 26.55098  2.82444   1.000 32.53211  ? 167 PRO A HA   1 
ATOM   2636 H HB2  . PRO A 1 172 ? 15.80154 25.65537  0.62891   1.000 15.65905  ? 167 PRO A HB2  1 
ATOM   2637 H HB3  . PRO A 1 172 ? 14.37488 25.14687  1.11003   1.000 15.65905  ? 167 PRO A HB3  1 
ATOM   2638 H HG2  . PRO A 1 172 ? 14.48834 26.54740  -0.92940  1.000 24.18479  ? 167 PRO A HG2  1 
ATOM   2639 H HG3  . PRO A 1 172 ? 13.31911 26.82593  0.11017   1.000 24.18479  ? 167 PRO A HG3  1 
ATOM   2640 H HD2  . PRO A 1 172 ? 15.75224 28.25673  -0.11333  1.000 26.46517  ? 167 PRO A HD2  1 
ATOM   2641 H HD3  . PRO A 1 172 ? 14.29344 28.88041  -0.02204  1.000 26.46517  ? 167 PRO A HD3  1 
ATOM   2642 N N    . ILE A 1 173 ? 17.48622 27.09111  2.65734   1.000 38.68877  ? 168 ILE A N    1 
ATOM   2643 C CA   . ILE A 1 173 ? 18.70601 26.89856  3.44542   1.000 19.43830  ? 168 ILE A CA   1 
ATOM   2644 C C    . ILE A 1 173 ? 18.50302 27.40509  4.86658   1.000 27.87693  ? 168 ILE A C    1 
ATOM   2645 O O    . ILE A 1 173 ? 19.10834 26.88308  5.80604   1.000 44.89721  ? 168 ILE A O    1 
ATOM   2646 C CB   . ILE A 1 173 ? 19.89796 27.62430  2.77788   1.000 32.69870  ? 168 ILE A CB   1 
ATOM   2647 C CG1  . ILE A 1 173 ? 20.37118 26.93292  1.48934   1.000 53.48733  ? 168 ILE A CG1  1 
ATOM   2648 C CG2  . ILE A 1 173 ? 21.07360 27.66832  3.69274   1.000 28.25354  ? 168 ILE A CG2  1 
ATOM   2649 C CD1  . ILE A 1 173 ? 20.35520 27.83698  0.22586   1.000 43.46766  ? 168 ILE A CD1  1 
ATOM   2650 H H    . ILE A 1 173 ? 17.56529 27.63838  1.99868   1.000 46.44893  ? 168 ILE A H    1 
ATOM   2651 H HA   . ILE A 1 173 ? 18.90246 25.94914  3.47564   1.000 23.34836  ? 168 ILE A HA   1 
ATOM   2652 H HB   . ILE A 1 173 ? 19.56877 28.51298  2.57107   1.000 39.26084  ? 168 ILE A HB   1 
ATOM   2653 H HG12 . ILE A 1 173 ? 21.28297 26.62864  1.61951   1.000 64.20719  ? 168 ILE A HG12 1 
ATOM   2654 H HG13 . ILE A 1 173 ? 19.79057 26.17583  1.31439   1.000 64.20719  ? 168 ILE A HG13 1 
ATOM   2655 H HG21 . ILE A 1 173 ? 21.80823 28.11308  3.24174   1.000 33.92665  ? 168 ILE A HG21 1 
ATOM   2656 H HG22 . ILE A 1 173 ? 20.83198 28.15859  4.49409   1.000 33.92665  ? 168 ILE A HG22 1 
ATOM   2657 H HG23 . ILE A 1 173 ? 21.32795 26.76127  3.92398   1.000 33.92665  ? 168 ILE A HG23 1 
ATOM   2658 H HD11 . ILE A 1 173 ? 20.66446 27.32137  -0.53533  1.000 52.18360  ? 168 ILE A HD11 1 
ATOM   2659 H HD12 . ILE A 1 173 ? 19.44900 28.14585  0.06999   1.000 52.18360  ? 168 ILE A HD12 1 
ATOM   2660 H HD13 . ILE A 1 173 ? 20.94241 28.59500  0.37248   1.000 52.18360  ? 168 ILE A HD13 1 
ATOM   2661 N N    . ARG A 1 174 ? 17.71250 28.47815  5.04208   1.000 27.40530  ? 169 ARG A N    1 
ATOM   2662 C CA   . ARG A 1 174 ? 17.47326 29.02178  6.37362   1.000 23.90608  ? 169 ARG A CA   1 
ATOM   2663 C C    . ARG A 1 174 ? 16.55344 28.09511  7.16463   1.000 13.53103  ? 169 ARG A C    1 
ATOM   2664 O O    . ARG A 1 174 ? 16.80566 27.81908  8.34134   1.000 24.74318  ? 169 ARG A O    1 
ATOM   2665 C CB   . ARG A 1 174 ? 16.89242 30.44266  6.27557   1.000 21.61803  ? 169 ARG A CB   1 
ATOM   2666 C CG   . ARG A 1 174 ? 16.36846 31.04222  7.61474   1.000 24.60461  ? 169 ARG A CG   1 
ATOM   2667 C CD   . ARG A 1 174 ? 16.11899 32.57217  7.58811   1.000 20.70843  ? 169 ARG A CD   1 
ATOM   2668 N NE   . ARG A 1 174 ? 15.49708 33.00991  8.83657   1.000 21.64617  ? 169 ARG A NE   1 
ATOM   2669 C CZ   . ARG A 1 174 ? 15.08764 34.24477  9.10256   1.000 22.86100  ? 169 ARG A CZ   1 
ATOM   2670 N NH1  . ARG A 1 174 ? 15.32290 35.25506  8.27757   1.000 23.43895  ? 169 ARG A NH1  1 
ATOM   2671 N NH2  . ARG A 1 174 ? 14.39936 34.46904  10.21265  1.000 21.46061  ? 169 ARG A NH2  1 
ATOM   2672 H H    . ARG A 1 174 ? 17.31068 28.90000  4.40948   1.000 32.90876  ? 169 ARG A H    1 
ATOM   2673 H HA   . ARG A 1 174 ? 18.31435 29.09484  6.85125   1.000 28.70970  ? 169 ARG A HA   1 
ATOM   2674 H HB2  . ARG A 1 174 ? 17.58639 31.03451  5.94538   1.000 25.96404  ? 169 ARG A HB2  1 
ATOM   2675 H HB3  . ARG A 1 174 ? 16.14735 30.42618  5.65469   1.000 25.96404  ? 169 ARG A HB3  1 
ATOM   2676 H HG2  . ARG A 1 174 ? 15.52672 30.61407  7.83625   1.000 29.54793  ? 169 ARG A HG2  1 
ATOM   2677 H HG3  . ARG A 1 174 ? 17.02290 30.86625  8.30874   1.000 29.54793  ? 169 ARG A HG3  1 
ATOM   2678 H HD2  . ARG A 1 174 ? 16.96360 33.03752  7.48328   1.000 24.87252  ? 169 ARG A HD2  1 
ATOM   2679 H HD3  . ARG A 1 174 ? 15.52558 32.79207  6.85299   1.000 24.87252  ? 169 ARG A HD3  1 
ATOM   2680 H HE   . ARG A 1 174 ? 15.38712 32.41778  9.45049   1.000 25.99781  ? 169 ARG A HE   1 
ATOM   2681 H HH11 . ARG A 1 174 ? 15.75244 35.12073  7.54473   1.000 28.14914  ? 169 ARG A HH11 1 
ATOM   2682 H HH12 . ARG A 1 174 ? 15.04602 36.04495  8.47511   1.000 28.14914  ? 169 ARG A HH12 1 
ATOM   2683 H HH21 . ARG A 1 174 ? 14.22400 33.81962  10.74847  1.000 25.77513  ? 169 ARG A HH21 1 
ATOM   2684 H HH22 . ARG A 1 174 ? 14.12809 35.26399  10.39720  1.000 25.77513  ? 169 ARG A HH22 1 
ATOM   2685 N N    . LEU A 1 175 ? 15.54096 27.54118  6.51063   1.000 17.56025  ? 170 LEU A N    1 
ATOM   2686 C CA   . LEU A 1 175 ? 14.63711 26.59248  7.16464   1.000 19.07210  ? 170 LEU A CA   1 
ATOM   2687 C C    . LEU A 1 175 ? 15.36197 25.30043  7.51359   1.000 19.03293  ? 170 LEU A C    1 
ATOM   2688 O O    . LEU A 1 175 ? 15.24334 24.80021  8.63493   1.000 14.33916  ? 170 LEU A O    1 
ATOM   2689 C CB   . LEU A 1 175 ? 13.42547 26.30141  6.25849   1.000 11.47895  ? 170 LEU A CB   1 
ATOM   2690 C CG   . LEU A 1 175 ? 12.49584 27.48418  5.96703   1.000 23.89565  ? 170 LEU A CG   1 
ATOM   2691 C CD1  . LEU A 1 175 ? 11.46798 27.09462  4.93980   1.000 12.30691  ? 170 LEU A CD1  1 
ATOM   2692 C CD2  . LEU A 1 175 ? 11.80081 27.97963  7.23555   1.000 25.91893  ? 170 LEU A CD2  1 
ATOM   2693 H H    . LEU A 1 175 ? 15.35078 27.69460  5.68608   1.000 21.09470  ? 170 LEU A H    1 
ATOM   2694 H HA   . LEU A 1 175 ? 14.31010 26.99091  7.98635   1.000 22.90892  ? 170 LEU A HA   1 
ATOM   2695 H HB2  . LEU A 1 175 ? 13.75755 25.98172  5.40502   1.000 13.79714  ? 170 LEU A HB2  1 
ATOM   2696 H HB3  . LEU A 1 175 ? 12.88912 25.61439  6.68421   1.000 13.79714  ? 170 LEU A HB3  1 
ATOM   2697 H HG   . LEU A 1 175 ? 13.03222 28.21438  5.62060   1.000 28.69719  ? 170 LEU A HG   1 
ATOM   2698 H HD11 . LEU A 1 175 ? 11.04330 27.89693  4.59796   1.000 14.79070  ? 170 LEU A HD11 1 
ATOM   2699 H HD12 . LEU A 1 175 ? 11.90775 26.61967  4.21735   1.000 14.79070  ? 170 LEU A HD12 1 
ATOM   2700 H HD13 . LEU A 1 175 ? 10.80562 26.52196  5.35721   1.000 14.79070  ? 170 LEU A HD13 1 
ATOM   2701 H HD21 . LEU A 1 175 ? 11.33826 27.23625  7.65309   1.000 31.12511  ? 170 LEU A HD21 1 
ATOM   2702 H HD22 . LEU A 1 175 ? 12.46805 28.33683  7.84225   1.000 31.12511  ? 170 LEU A HD22 1 
ATOM   2703 H HD23 . LEU A 1 175 ? 11.16545 28.67279  6.99734   1.000 31.12511  ? 170 LEU A HD23 1 
ATOM   2704 N N    . GLY A 1 176 ? 16.10900 24.73675  6.56239   1.000 12.64522  ? 171 GLY A N    1 
ATOM   2705 C CA   . GLY A 1 176 ? 16.96141 23.59199  6.83863   1.000 10.92982  ? 171 GLY A CA   1 
ATOM   2706 C C    . GLY A 1 176 ? 17.86382 23.74702  8.06236   1.000 14.77453  ? 171 GLY A C    1 
ATOM   2707 O O    . GLY A 1 176 ? 17.94954 22.79337  8.88882   1.000 20.65846  ? 171 GLY A O    1 
ATOM   2708 H H    . GLY A 1 176 ? 16.13634 25.00420  5.74549   1.000 15.19667  ? 171 GLY A H    1 
ATOM   2709 H HA2  . GLY A 1 176 ? 16.40086 22.81330  6.98122   1.000 13.13819  ? 171 GLY A HA2  1 
ATOM   2710 H HA3  . GLY A 1 176 ? 17.53080 23.43461  6.06926   1.000 13.13819  ? 171 GLY A HA3  1 
ATOM   2711 N N    . ALA A 1 178 ? 18.26331 25.29883  10.83668  1.000 8.38695   ? 173 ALA A N    1 
ATOM   2712 C CA   . ALA A 1 178 ? 17.26630 25.73391  11.83831  1.000 33.78295  ? 173 ALA A CA   1 
ATOM   2713 C C    . ALA A 1 178 ? 16.39396 24.58745  12.30785  1.000 12.89079  ? 173 ALA A C    1 
ATOM   2714 O O    . ALA A 1 178 ? 16.18252 24.44765  13.48915  1.000 6.55612   ? 173 ALA A O    1 
ATOM   2715 C CB   . ALA A 1 178 ? 16.37230 26.83817  11.31633  1.000 20.68955  ? 173 ALA A CB   1 
ATOM   2716 H H    . ALA A 1 178 ? 18.15039 25.65302  10.05811  1.000 10.08674  ? 173 ALA A H    1 
ATOM   2717 H HA   . ALA A 1 178 ? 17.77170 26.07990  12.59048  1.000 40.56194  ? 173 ALA A HA   1 
ATOM   2718 H HB1  . ALA A 1 178 ? 16.90507 27.63679  11.17757  1.000 24.84986  ? 173 ALA A HB1  1 
ATOM   2719 H HB2  . ALA A 1 178 ? 15.97696 26.55435  10.47724  1.000 24.84986  ? 173 ALA A HB2  1 
ATOM   2720 H HB3  . ALA A 1 178 ? 15.67528 27.01454  11.96746  1.000 24.84986  ? 173 ALA A HB3  1 
ATOM   2721 N N    . LEU A 1 179 ? 15.88175 23.78334  11.37298  1.000 20.61602  ? 174 LEU A N    1 
ATOM   2722 C CA   . LEU A 1 179 ? 15.35155 22.46240  11.73082  1.000 14.64187  ? 174 LEU A CA   1 
ATOM   2723 C C    . LEU A 1 179 ? 16.43385 21.62368  12.39316  1.000 15.64622  ? 174 LEU A C    1 
ATOM   2724 O O    . LEU A 1 179 ? 16.19221 20.95218  13.40443  1.000 9.17032   ? 174 LEU A O    1 
ATOM   2725 C CB   . LEU A 1 179 ? 14.82926 21.73384  10.47733  1.000 13.93289  ? 174 LEU A CB   1 
ATOM   2726 C CG   . LEU A 1 179 ? 14.27842 20.30552  10.63965  1.000 12.01086  ? 174 LEU A CG   1 
ATOM   2727 C CD1  . LEU A 1 179 ? 12.92010 20.43516  11.25632  1.000 17.60471  ? 174 LEU A CD1  1 
ATOM   2728 C CD2  . LEU A 1 179 ? 14.14999 19.48452  9.30226   1.000 15.11489  ? 174 LEU A CD2  1 
ATOM   2729 H H    . LEU A 1 179 ? 15.82918 23.97395  10.53602  1.000 24.76162  ? 174 LEU A H    1 
ATOM   2730 H HA   . LEU A 1 179 ? 14.61003 22.58066  12.34488  1.000 17.59264  ? 174 LEU A HA   1 
ATOM   2731 H HB2  . LEU A 1 179 ? 14.10964 22.26794  10.10616  1.000 16.74187  ? 174 LEU A HB2  1 
ATOM   2732 H HB3  . LEU A 1 179 ? 15.56179 21.67811  9.84392   1.000 16.74187  ? 174 LEU A HB3  1 
ATOM   2733 H HG   . LEU A 1 179 ? 14.90534 19.80336  11.18344  1.000 14.43543  ? 174 LEU A HG   1 
ATOM   2734 H HD11 . LEU A 1 179 ? 12.33326 20.89296  10.63427  1.000 21.14805  ? 174 LEU A HD11 1 
ATOM   2735 H HD12 . LEU A 1 179 ? 12.57389 19.54929  11.44678  1.000 21.14805  ? 174 LEU A HD12 1 
ATOM   2736 H HD13 . LEU A 1 179 ? 12.99372 20.94526  12.07807  1.000 21.14805  ? 174 LEU A HD13 1 
ATOM   2737 H HD21 . LEU A 1 179 ? 13.93476 18.56332  9.51664   1.000 18.16027  ? 174 LEU A HD21 1 
ATOM   2738 H HD22 . LEU A 1 179 ? 13.44454 19.87159  8.76059   1.000 18.16027  ? 174 LEU A HD22 1 
ATOM   2739 H HD23 . LEU A 1 179 ? 14.99341 19.52465  8.82483   1.000 18.16027  ? 174 LEU A HD23 1 
ATOM   2740 N N    . ASN A 1 180 ? 17.62630 21.60863  11.78703  1.000 11.48154  ? 175 ASN A N    1 
ATOM   2741 C CA   . ASN A 1 180 ? 18.73381 20.82935  12.30687  1.000 12.73683  ? 175 ASN A CA   1 
ATOM   2742 C C    . ASN A 1 180 ? 19.19593 21.36001  13.66406  1.000 29.74077  ? 175 ASN A C    1 
ATOM   2743 O O    . ASN A 1 180 ? 19.52635 20.56056  14.54924  1.000 14.98897  ? 175 ASN A O    1 
ATOM   2744 C CB   . ASN A 1 180 ? 19.86792 20.80819  11.27817  1.000 24.17866  ? 175 ASN A CB   1 
ATOM   2745 C CG   . ASN A 1 180 ? 19.64874 19.75704  10.16947  1.000 21.79537  ? 175 ASN A CG   1 
ATOM   2746 O OD1  . ASN A 1 180 ? 18.51546 19.46762  9.76573   1.000 12.07799  ? 175 ASN A OD1  1 
ATOM   2747 N ND2  . ASN A 1 180 ? 20.75231 19.18656  9.67556   1.000 30.07394  ? 175 ASN A ND2  1 
ATOM   2748 H H    . ASN A 1 180 ? 17.81368 22.04548  11.07034  1.000 13.80024  ? 175 ASN A H    1 
ATOM   2749 H HA   . ASN A 1 180 ? 18.45889 19.90954  12.44572  1.000 15.30660  ? 175 ASN A HA   1 
ATOM   2750 H HB2  . ASN A 1 180 ? 19.92910 21.67992  10.85715  1.000 29.03679  ? 175 ASN A HB2  1 
ATOM   2751 H HB3  . ASN A 1 180 ? 20.70044 20.59871  11.72976  1.000 29.03679  ? 175 ASN A HB3  1 
ATOM   2752 H HD21 . ASN A 1 180 ? 20.68936 18.59378  9.05568   1.000 36.11112  ? 175 ASN A HD21 1 
ATOM   2753 H HD22 . ASN A 1 180 ? 21.52518 19.41236  9.97772   1.000 36.11112  ? 175 ASN A HD22 1 
ATOM   2754 N N    . PHE A 1 181 ? 19.14701 22.68532  13.88647  1.000 24.73911  ? 176 PHE A N    1 
ATOM   2755 C CA   . PHE A 1 181 ? 19.54500 23.21039  15.20058  1.000 17.63986  ? 176 PHE A CA   1 
ATOM   2756 C C    . PHE A 1 181 ? 18.56558 22.79008  16.30082  1.000 19.77812  ? 176 PHE A C    1 
ATOM   2757 O O    . PHE A 1 181 ? 18.96593 22.57686  17.44733  1.000 4.23923   ? 176 PHE A O    1 
ATOM   2758 C CB   . PHE A 1 181 ? 19.64939 24.72693  15.14501  1.000 17.74717  ? 176 PHE A CB   1 
ATOM   2759 C CG   . PHE A 1 181 ? 20.51432 25.35245  16.24788  1.000 9.59657   ? 176 PHE A CG   1 
ATOM   2760 C CD1  . PHE A 1 181 ? 21.41648 24.60448  17.00298  1.000 18.75885  ? 176 PHE A CD1  1 
ATOM   2761 C CD2  . PHE A 1 181 ? 20.42021 26.71336  16.50857  1.000 32.30394  ? 176 PHE A CD2  1 
ATOM   2762 C CE1  . PHE A 1 181 ? 22.22095 25.20944  17.98029  1.000 3.28372   ? 176 PHE A CE1  1 
ATOM   2763 C CE2  . PHE A 1 181 ? 21.21881 27.33044  17.49053  1.000 26.59445  ? 176 PHE A CE2  1 
ATOM   2764 C CZ   . PHE A 1 181 ? 22.10702 26.57764  18.22831  1.000 15.82640  ? 176 PHE A CZ   1 
ATOM   2765 H H    . PHE A 1 181 ? 18.89679 23.27723  13.31495  1.000 29.70933  ? 176 PHE A H    1 
ATOM   2766 H HA   . PHE A 1 181 ? 20.41871 22.85364  15.42479  1.000 21.19024  ? 176 PHE A HA   1 
ATOM   2767 H HB2  . PHE A 1 181 ? 20.03751 24.97790  14.29220  1.000 21.31900  ? 176 PHE A HB2  1 
ATOM   2768 H HB3  . PHE A 1 181 ? 18.75780 25.10022  15.22644  1.000 21.31900  ? 176 PHE A HB3  1 
ATOM   2769 H HD1  . PHE A 1 181 ? 21.48624 23.68877  16.85633  1.000 22.53302  ? 176 PHE A HD1  1 
ATOM   2770 H HD2  . PHE A 1 181 ? 19.81639 27.22850  16.02387  1.000 38.78713  ? 176 PHE A HD2  1 
ATOM   2771 H HE1  . PHE A 1 181 ? 22.83010 24.69848  18.46275  1.000 3.96286   ? 176 PHE A HE1  1 
ATOM   2772 H HE2  . PHE A 1 181 ? 21.14702 28.24534  17.64120  1.000 31.93574  ? 176 PHE A HE2  1 
ATOM   2773 H HZ   . PHE A 1 181 ? 22.62676 26.97897  18.88687  1.000 19.01409  ? 176 PHE A HZ   1 
ATOM   2774 N N    . SER A 1 182 ? 17.28405 22.66126  15.96156  1.000 24.86668  ? 177 SER A N    1 
ATOM   2775 C CA   . SER A 1 182 ? 16.29773 22.22857  16.93967  1.000 18.86627  ? 177 SER A CA   1 
ATOM   2776 C C    . SER A 1 182 ? 16.50060 20.75684  17.31450  1.000 23.96469  ? 177 SER A C    1 
ATOM   2777 O O    . SER A 1 182 ? 16.29109 20.37253  18.48085  1.000 20.19901  ? 177 SER A O    1 
ATOM   2778 C CB   . SER A 1 182 ? 14.90153 22.50940  16.37597  1.000 27.52913  ? 177 SER A CB   1 
ATOM   2779 O OG   . SER A 1 182 ? 14.51490 21.60363  15.34569  1.000 26.52519  ? 177 SER A OG   1 
ATOM   2780 H H    . SER A 1 182 ? 16.96480 22.81721  15.17840  1.000 29.86241  ? 177 SER A H    1 
ATOM   2781 H HA   . SER A 1 182 ? 16.38777 22.73050  17.76481  1.000 22.66192  ? 177 SER A HA   1 
ATOM   2782 H HB2  . SER A 1 182 ? 14.26001 22.44019  17.10024  1.000 33.05736  ? 177 SER A HB2  1 
ATOM   2783 H HB3  . SER A 1 182 ? 14.89438 23.40817  16.01120  1.000 33.05736  ? 177 SER A HB3  1 
ATOM   2784 H HG   . SER A 1 182 ? 15.05502 21.65081  14.70409  1.000 31.85263  ? 177 SER A HG   1 
ATOM   2785 N N    . VAL A 1 183 ? 16.90620 19.92316  16.34717  1.000 18.01000  ? 178 VAL A N    1 
ATOM   2786 C CA   . VAL A 1 183 ? 17.26664 18.52156  16.62184  1.000 22.71510  ? 178 VAL A CA   1 
ATOM   2787 C C    . VAL A 1 183 ? 18.47369 18.45862  17.56623  1.000 14.33386  ? 178 VAL A C    1 
ATOM   2788 O O    . VAL A 1 183 ? 18.46799 17.70792  18.54706  1.000 25.30453  ? 178 VAL A O    1 
ATOM   2789 C CB   . VAL A 1 183 ? 17.55322 17.77021  15.29857  1.000 22.37442  ? 178 VAL A CB   1 
ATOM   2790 C CG1  . VAL A 1 183 ? 18.13153 16.40178  15.58450  1.000 13.79181  ? 178 VAL A CG1  1 
ATOM   2791 C CG2  . VAL A 1 183 ? 16.30535 17.65837  14.37768  1.000 8.93700   ? 178 VAL A CG2  1 
ATOM   2792 H H    . VAL A 1 183 ? 16.98245 20.14284  15.51920  1.000 21.63440  ? 178 VAL A H    1 
ATOM   2793 H HA   . VAL A 1 183 ? 16.51583 18.09107  17.05985  1.000 27.28052  ? 178 VAL A HA   1 
ATOM   2794 H HB   . VAL A 1 183 ? 18.20498 18.29444  14.80737  1.000 26.87171  ? 178 VAL A HB   1 
ATOM   2795 H HG11 . VAL A 1 183 ? 17.87299 16.13032  16.47914  1.000 16.57258  ? 178 VAL A HG11 1 
ATOM   2796 H HG12 . VAL A 1 183 ? 17.78551 15.77056  14.93433  1.000 16.57258  ? 178 VAL A HG12 1 
ATOM   2797 H HG13 . VAL A 1 183 ? 19.09824 16.44752  15.51911  1.000 16.57258  ? 178 VAL A HG13 1 
ATOM   2798 H HG21 . VAL A 1 183 ? 15.60802 18.24001  14.71874  1.000 10.74680  ? 178 VAL A HG21 1 
ATOM   2799 H HG22 . VAL A 1 183 ? 16.55093 17.92818  13.47891  1.000 10.74680  ? 178 VAL A HG22 1 
ATOM   2800 H HG23 . VAL A 1 183 ? 15.99677 16.73877  14.37429  1.000 10.74680  ? 178 VAL A HG23 1 
ATOM   2801 N N    . PHE A 1 184 ? 19.51618 19.27322  17.29392  1.000 11.39215  ? 179 PHE A N    1 
ATOM   2802 C CA   . PHE A 1 184 ? 20.65247 19.40184  18.20771  1.000 22.43553  ? 179 PHE A CA   1 
ATOM   2803 C C    . PHE A 1 184 ? 20.18857 19.59863  19.65214  1.000 20.75661  ? 179 PHE A C    1 
ATOM   2804 O O    . PHE A 1 184 ? 20.65651 18.91101  20.57053  1.000 17.69059  ? 179 PHE A O    1 
ATOM   2805 C CB   . PHE A 1 184 ? 21.55666 20.57553  17.78076  1.000 7.05061   ? 179 PHE A CB   1 
ATOM   2806 C CG   . PHE A 1 184 ? 22.62894 20.92973  18.80031  1.000 11.35967  ? 179 PHE A CG   1 
ATOM   2807 C CD1  . PHE A 1 184 ? 23.79057 20.19974  18.90018  1.000 13.81546  ? 179 PHE A CD1  1 
ATOM   2808 C CD2  . PHE A 1 184 ? 22.47649 22.00406  19.64287  1.000 18.85759  ? 179 PHE A CD2  1 
ATOM   2809 C CE1  . PHE A 1 184 ? 24.76732 20.54026  19.82401  1.000 9.47992   ? 179 PHE A CE1  1 
ATOM   2810 C CE2  . PHE A 1 184 ? 23.45056 22.32356  20.57982  1.000 35.48205  ? 179 PHE A CE2  1 
ATOM   2811 C CZ   . PHE A 1 184 ? 24.58562 21.58616  20.66656  1.000 22.97333  ? 179 PHE A CZ   1 
ATOM   2812 H H    . PHE A 1 184 ? 19.58234 19.75778  16.58651  1.000 13.69298  ? 179 PHE A H    1 
ATOM   2813 H HA   . PHE A 1 184 ? 21.17128 18.58367  18.15946  1.000 26.94504  ? 179 PHE A HA   1 
ATOM   2814 H HB2  . PHE A 1 184 ? 22.00291 20.33950  16.95248  1.000 8.48313   ? 179 PHE A HB2  1 
ATOM   2815 H HB3  . PHE A 1 184 ? 21.00428 21.36170  17.64765  1.000 8.48313   ? 179 PHE A HB3  1 
ATOM   2816 H HD1  . PHE A 1 184 ? 23.92265 19.46845  18.34101  1.000 16.60095  ? 179 PHE A HD1  1 
ATOM   2817 H HD2  . PHE A 1 184 ? 21.70875 22.52571  19.58490  1.000 22.65151  ? 179 PHE A HD2  1 
ATOM   2818 H HE1  . PHE A 1 184 ? 25.55423 20.04635  19.86573  1.000 11.39831  ? 179 PHE A HE1  1 
ATOM   2819 H HE2  . PHE A 1 184 ? 23.32393 23.04677  21.15064  1.000 42.60087  ? 179 PHE A HE2  1 
ATOM   2820 H HZ   . PHE A 1 184 ? 25.23405 21.79656  21.29915  1.000 27.59039  ? 179 PHE A HZ   1 
ATOM   2821 N N    . HIS A 1 185 ? 19.26397 20.54552  19.86130  1.000 14.96202  ? 180 HIS A N    1 
ATOM   2822 C CA   . HIS A 1 185 ? 18.79889 20.88465  21.19512  1.000 15.14299  ? 180 HIS A CA   1 
ATOM   2823 C C    . HIS A 1 185 ? 18.10310 19.70298  21.83691  1.000 15.70072  ? 180 HIS A C    1 
ATOM   2824 O O    . HIS A 1 185 ? 18.30598 19.42417  23.03049  1.000 14.57592  ? 180 HIS A O    1 
ATOM   2825 C CB   . HIS A 1 185 ? 17.81083 22.07949  21.15953  1.000 16.99630  ? 180 HIS A CB   1 
ATOM   2826 C CG   . HIS A 1 185 ? 18.45797 23.39249  20.86173  1.000 22.49092  ? 180 HIS A CG   1 
ATOM   2827 N ND1  . HIS A 1 185 ? 19.55922 23.85835  21.54843  1.000 10.63990  ? 180 HIS A ND1  1 
ATOM   2828 C CD2  . HIS A 1 185 ? 18.16295 24.34176  19.94719  1.000 21.25256  ? 180 HIS A CD2  1 
ATOM   2829 C CE1  . HIS A 1 185 ? 19.91920 25.02406  21.06891  1.000 7.52931   ? 180 HIS A CE1  1 
ATOM   2830 N NE2  . HIS A 1 185 ? 19.08614 25.34122  20.09400  1.000 13.87768  ? 180 HIS A NE2  1 
ATOM   2831 H H    . HIS A 1 185 ? 18.89140 21.00609  19.23786  1.000 17.97682  ? 180 HIS A H    1 
ATOM   2832 H HA   . HIS A 1 185 ? 19.57319 21.14207  21.71961  1.000 18.19399  ? 180 HIS A HA   1 
ATOM   2833 H HB2  . HIS A 1 185 ? 17.14753 21.91438  20.47129  1.000 20.41796  ? 180 HIS A HB2  1 
ATOM   2834 H HB3  . HIS A 1 185 ? 17.37952 22.15250  22.02529  1.000 20.41796  ? 180 HIS A HB3  1 
ATOM   2835 H HD2  . HIS A 1 185 ? 17.46438 24.32020  19.33365  1.000 25.52548  ? 180 HIS A HD2  1 
ATOM   2836 H HE1  . HIS A 1 185 ? 20.63600 25.53809  21.36365  1.000 9.05757   ? 180 HIS A HE1  1 
ATOM   2837 H HE2  . HIS A 1 185 ? 19.11879 26.06177  19.62567  1.000 16.67561  ? 180 HIS A HE2  1 
ATOM   2838 N N    . TYR A 1 186 ? 17.25470 19.01578  21.06417  1.000 18.13310  ? 181 TYR A N    1 
ATOM   2839 C CA   . TYR A 1 186 ? 16.42243 17.95311  21.62685  1.000 32.11738  ? 181 TYR A CA   1 
ATOM   2840 C C    . TYR A 1 186 ? 17.22839 16.69041  21.94439  1.000 33.34259  ? 181 TYR A C    1 
ATOM   2841 O O    . TYR A 1 186 ? 17.10437 16.11584  23.03752  1.000 21.27350  ? 181 TYR A O    1 
ATOM   2842 C CB   . TYR A 1 186 ? 15.28963 17.60908  20.66144  1.000 24.16653  ? 181 TYR A CB   1 
ATOM   2843 C CG   . TYR A 1 186 ? 14.22415 16.74930  21.30599  1.000 18.33170  ? 181 TYR A CG   1 
ATOM   2844 C CD1  . TYR A 1 186 ? 13.25941 17.32984  22.11576  1.000 30.92102  ? 181 TYR A CD1  1 
ATOM   2845 C CD2  . TYR A 1 186 ? 14.19761 15.37039  21.13853  1.000 28.80969  ? 181 TYR A CD2  1 
ATOM   2846 C CE1  . TYR A 1 186 ? 12.28668 16.57864  22.71730  1.000 26.05405  ? 181 TYR A CE1  1 
ATOM   2847 C CE2  . TYR A 1 186 ? 13.20743 14.59685  21.73882  1.000 18.48575  ? 181 TYR A CE2  1 
ATOM   2848 C CZ   . TYR A 1 186 ? 12.26656 15.22019  22.53742  1.000 31.96473  ? 181 TYR A CZ   1 
ATOM   2849 O OH   . TYR A 1 186 ? 11.27991 14.52329  23.17398  1.000 38.30855  ? 181 TYR A OH   1 
ATOM   2850 H H    . TYR A 1 186 ? 17.14440 19.14490  20.22110  1.000 21.78212  ? 181 TYR A H    1 
ATOM   2851 H HA   . TYR A 1 186 ? 16.04549 18.28419  22.45703  1.000 38.56325  ? 181 TYR A HA   1 
ATOM   2852 H HB2  . TYR A 1 186 ? 14.87192 18.42997  20.35722  1.000 29.02224  ? 181 TYR A HB2  1 
ATOM   2853 H HB3  . TYR A 1 186 ? 15.65393 17.12233  19.90562  1.000 29.02224  ? 181 TYR A HB3  1 
ATOM   2854 H HD1  . TYR A 1 186 ? 13.27392 18.24956  22.25287  1.000 37.12762  ? 181 TYR A HD1  1 
ATOM   2855 H HD2  . TYR A 1 186 ? 14.84965 14.95857  20.61876  1.000 34.59403  ? 181 TYR A HD2  1 
ATOM   2856 H HE1  . TYR A 1 186 ? 11.64122 16.98868  23.24659  1.000 31.28726  ? 181 TYR A HE1  1 
ATOM   2857 H HE2  . TYR A 1 186 ? 13.17950 13.67697  21.60486  1.000 22.20530  ? 181 TYR A HE2  1 
ATOM   2858 H HH   . TYR A 1 186 ? 11.48562 13.71011  23.21883  1.000 45.99267  ? 181 TYR A HH   1 
ATOM   2859 N N    . GLU A 1 187 ? 18.05127 16.23593  21.00197  1.000 17.57307  ? 182 GLU A N    1 
ATOM   2860 C CA   . GLU A 1 187 ? 18.64299 14.91042  21.10919  1.000 27.68457  ? 182 GLU A CA   1 
ATOM   2861 C C    . GLU A 1 187 ? 20.07771 14.92486  21.63423  1.000 15.50878  ? 182 GLU A C    1 
ATOM   2862 O O    . GLU A 1 187 ? 20.54213 13.89079  22.11773  1.000 24.12699  ? 182 GLU A O    1 
ATOM   2863 C CB   . GLU A 1 187 ? 18.60875 14.18318  19.74453  1.000 45.30830  ? 182 GLU A CB   1 
ATOM   2864 C CG   . GLU A 1 187 ? 17.21041 14.07016  19.05586  1.000 40.37349  ? 182 GLU A CG   1 
ATOM   2865 C CD   . GLU A 1 187 ? 16.43105 12.79509  19.40680  1.000 45.09677  ? 182 GLU A CD   1 
ATOM   2866 O OE1  . GLU A 1 187 ? 16.77810 12.12343  20.41004  1.000 50.45154  ? 182 GLU A OE1  1 
ATOM   2867 O OE2  . GLU A 1 187 ? 15.45779 12.46613  18.68186  1.000 28.19932  ? 182 GLU A OE2  1 
ATOM   2868 H H    . GLU A 1 187 ? 18.27884 16.67435  20.29798  1.000 21.11009  ? 182 GLU A H    1 
ATOM   2869 H HA   . GLU A 1 187 ? 18.10865 14.38930  21.72872  1.000 33.24388  ? 182 GLU A HA   1 
ATOM   2870 H HB2  . GLU A 1 187 ? 19.19026 14.66130  19.13285  1.000 54.39236  ? 182 GLU A HB2  1 
ATOM   2871 H HB3  . GLU A 1 187 ? 18.93616 13.27956  19.87556  1.000 54.39236  ? 182 GLU A HB3  1 
ATOM   2872 H HG2  . GLU A 1 187 ? 16.66936 14.82807  19.32741  1.000 48.47059  ? 182 GLU A HG2  1 
ATOM   2873 H HG3  . GLU A 1 187 ? 17.33710 14.08054  18.09423  1.000 48.47059  ? 182 GLU A HG3  1 
ATOM   2874 N N    . ILE A 1 188 ? 20.77045 16.04943  21.59203  1.000 16.34099  ? 183 ILE A N    1 
ATOM   2875 C CA   . ILE A 1 188 ? 22.18397 16.13094  21.98190  1.000 9.23144   ? 183 ILE A CA   1 
ATOM   2876 C C    . ILE A 1 188 ? 22.37312 16.97796  23.22473  1.000 15.38809  ? 183 ILE A C    1 
ATOM   2877 O O    . ILE A 1 188 ? 23.14652 16.62898  24.10867  1.000 38.04508  ? 183 ILE A O    1 
ATOM   2878 C CB   . ILE A 1 188 ? 23.05104 16.70207  20.83455  1.000 31.16944  ? 183 ILE A CB   1 
ATOM   2879 C CG1  . ILE A 1 188 ? 22.87820 15.93557  19.52614  1.000 23.16308  ? 183 ILE A CG1  1 
ATOM   2880 C CG2  . ILE A 1 188 ? 24.52448 16.75470  21.28998  1.000 15.41970  ? 183 ILE A CG2  1 
ATOM   2881 C CD1  . ILE A 1 188 ? 23.46231 14.53772  19.50365  1.000 22.39521  ? 183 ILE A CD1  1 
ATOM   2882 H H    . ILE A 1 188 ? 20.44271 16.80209  21.33571  1.000 19.63158  ? 183 ILE A H    1 
ATOM   2883 H HA   . ILE A 1 188 ? 22.48171 15.22859  22.17686  1.000 11.10013  ? 183 ILE A HA   1 
ATOM   2884 H HB   . ILE A 1 188 ? 22.74549 17.60255  20.64302  1.000 37.42572  ? 183 ILE A HB   1 
ATOM   2885 H HG12 . ILE A 1 188 ? 21.92896 15.85408  19.34393  1.000 27.81809  ? 183 ILE A HG12 1 
ATOM   2886 H HG13 . ILE A 1 188 ? 23.30978 16.43953  18.81856  1.000 27.81809  ? 183 ILE A HG13 1 
ATOM   2887 H HG21 . ILE A 1 188 ? 24.63981 17.49932  21.90083  1.000 18.52604  ? 183 ILE A HG21 1 
ATOM   2888 H HG22 . ILE A 1 188 ? 24.74684 15.92289  21.73669  1.000 18.52604  ? 183 ILE A HG22 1 
ATOM   2889 H HG23 . ILE A 1 188 ? 25.09140 16.87419  20.51202  1.000 18.52604  ? 183 ILE A HG23 1 
ATOM   2890 H HD11 . ILE A 1 188 ? 23.38755 14.17862  18.60567  1.000 26.89665  ? 183 ILE A HD11 1 
ATOM   2891 H HD12 . ILE A 1 188 ? 24.39516 14.58100  19.76598  1.000 26.89665  ? 183 ILE A HD12 1 
ATOM   2892 H HD13 . ILE A 1 188 ? 22.96946 13.97947  20.12523  1.000 26.89665  ? 183 ILE A HD13 1 
ATOM   2893 N N    . ALA A 1 189 ? 21.72108 18.13823  23.27631  1.000 29.78446  ? 184 ALA A N    1 
ATOM   2894 C CA   . ALA A 1 189 ? 22.00400 19.14233  24.29841  1.000 13.74340  ? 184 ALA A CA   1 
ATOM   2895 C C    . ALA A 1 189 ? 21.14722 19.01057  25.54396  1.000 14.55945  ? 184 ALA A C    1 
ATOM   2896 O O    . ALA A 1 189 ? 21.37322 19.75793  26.48127  1.000 28.39105  ? 184 ALA A O    1 
ATOM   2897 C CB   . ALA A 1 189 ? 21.81962 20.54662  23.71187  1.000 17.38614  ? 184 ALA A CB   1 
ATOM   2898 H H    . ALA A 1 189 ? 21.10370 18.36898  22.72386  1.000 35.76375  ? 184 ALA A H    1 
ATOM   2899 H HA   . ALA A 1 189 ? 22.92863 19.03580  24.57155  1.000 16.51448  ? 184 ALA A HA   1 
ATOM   2900 H HB1  . ALA A 1 189 ? 20.88790 20.66849  23.47115  1.000 20.88576  ? 184 ALA A HB1  1 
ATOM   2901 H HB2  . ALA A 1 189 ? 22.07793 21.20327  24.37744  1.000 20.88576  ? 184 ALA A HB2  1 
ATOM   2902 H HB3  . ALA A 1 189 ? 22.37909 20.63597  22.92452  1.000 20.88576  ? 184 ALA A HB3  1 
ATOM   2903 N N    . ASN A 1 190 ? 20.19155 18.08267  25.58757  1.000 27.40090  ? 185 ASN A N    1 
ATOM   2904 C CA   . ASN A 1 190 ? 19.28346 17.92180  26.72758  1.000 21.75526  ? 185 ASN A CA   1 
ATOM   2905 C C    . ASN A 1 190 ? 18.60147 19.24195  27.09171  1.000 24.60939  ? 185 ASN A C    1 
ATOM   2906 O O    . ASN A 1 190 ? 18.59736 19.68915  28.25224  1.000 23.38047  ? 185 ASN A O    1 
ATOM   2907 C CB   . ASN A 1 190 ? 20.03113 17.32897  27.92497  1.000 30.63891  ? 185 ASN A CB   1 
ATOM   2908 C CG   . ASN A 1 190 ? 19.09493 16.83513  29.03282  1.000 34.59385  ? 185 ASN A CG   1 
ATOM   2909 O OD1  . ASN A 1 190 ? 17.89889 16.62805  28.81879  1.000 49.89030  ? 185 ASN A OD1  1 
ATOM   2910 N ND2  . ASN A 1 190 ? 19.65135 16.64912  30.23441  1.000 55.10882  ? 185 ASN A ND2  1 
ATOM   2911 H H    . ASN A 1 190 ? 20.04414 17.51966  24.95441  1.000 32.90348  ? 185 ASN A H    1 
ATOM   2912 H HA   . ASN A 1 190 ? 18.57879 17.30505  26.47465  1.000 26.12871  ? 185 ASN A HA   1 
ATOM   2913 H HB2  . ASN A 1 190 ? 20.56084 16.57445  27.62330  1.000 36.78909  ? 185 ASN A HB2  1 
ATOM   2914 H HB3  . ASN A 1 190 ? 20.60902 18.00972  28.30381  1.000 36.78909  ? 185 ASN A HB3  1 
ATOM   2915 H HD21 . ASN A 1 190 ? 19.17144 16.37276  30.89237  1.000 66.15299  ? 185 ASN A HD21 1 
ATOM   2916 H HD22 . ASN A 1 190 ? 20.48911 16.80586  30.34925  1.000 66.15299  ? 185 ASN A HD22 1 
ATOM   2917 N N    . SER A 1 191 ? 17.99410 19.85710  26.07346  1.000 19.00135  ? 186 SER A N    1 
ATOM   2918 C CA   . SER A 1 191 ? 17.33628 21.16552  26.19678  1.000 12.34269  ? 186 SER A CA   1 
ATOM   2919 C C    . SER A 1 191 ? 16.05466 21.14528  25.38474  1.000 10.70789  ? 186 SER A C    1 
ATOM   2920 O O    . SER A 1 191 ? 15.92865 21.86289  24.40112  1.000 15.52957  ? 186 SER A O    1 
ATOM   2921 C CB   . SER A 1 191 ? 18.23054 22.29456  25.67457  1.000 9.60047   ? 186 SER A CB   1 
ATOM   2922 O OG   . SER A 1 191 ? 19.42758 22.49616  26.39578  1.000 18.78429  ? 186 SER A OG   1 
ATOM   2923 H H    . SER A 1 191 ? 17.94750 19.52948  25.27968  1.000 22.82402  ? 186 SER A H    1 
ATOM   2924 H HA   . SER A 1 191 ? 17.14383 21.31756  27.13526  1.000 14.83363  ? 186 SER A HA   1 
ATOM   2925 H HB2  . SER A 1 191 ? 18.46675 22.08746  24.75685  1.000 11.54297  ? 186 SER A HB2  1 
ATOM   2926 H HB3  . SER A 1 191 ? 17.72010 23.11872  25.70786  1.000 11.54297  ? 186 SER A HB3  1 
ATOM   2927 H HG   . SER A 1 191 ? 20.04811 22.04434  26.05460  1.000 22.56355  ? 186 SER A HG   1 
ATOM   2928 N N    . PRO A 1 192 ? 15.08873 20.30732  25.74593  1.000 11.77427  ? 187 PRO A N    1 
ATOM   2929 C CA   . PRO A 1 192 ? 13.95336 20.07770  24.83666  1.000 16.79366  ? 187 PRO A CA   1 
ATOM   2930 C C    . PRO A 1 192 ? 12.99754 21.25536  24.71370  1.000 22.01715  ? 187 PRO A C    1 
ATOM   2931 O O    . PRO A 1 192 ? 12.26319 21.34548  23.70679  1.000 25.71393  ? 187 PRO A O    1 
ATOM   2932 C CB   . PRO A 1 192 ? 13.25300 18.84090  25.43582  1.000 22.89318  ? 187 PRO A CB   1 
ATOM   2933 C CG   . PRO A 1 192 ? 13.77788 18.72034  26.84232  1.000 11.78650  ? 187 PRO A CG   1 
ATOM   2934 C CD   . PRO A 1 192 ? 15.10488 19.38705  26.89539  1.000 17.87113  ? 187 PRO A CD   1 
ATOM   2935 H HA   . PRO A 1 192 ? 14.28835 19.85652  23.95362  1.000 20.17480  ? 187 PRO A HA   1 
ATOM   2936 H HB2  . PRO A 1 192 ? 12.29250 18.97636  25.43645  1.000 27.49422  ? 187 PRO A HB2  1 
ATOM   2937 H HB3  . PRO A 1 192 ? 13.47664 18.05343  24.91545  1.000 27.49422  ? 187 PRO A HB3  1 
ATOM   2938 H HG2  . PRO A 1 192 ? 13.15971 19.15406  27.45114  1.000 14.16620  ? 187 PRO A HG2  1 
ATOM   2939 H HG3  . PRO A 1 192 ? 13.86451 17.78155  27.07049  1.000 14.16620  ? 187 PRO A HG3  1 
ATOM   2940 H HD2  . PRO A 1 192 ? 15.20841 19.87797  27.72556  1.000 21.46775  ? 187 PRO A HD2  1 
ATOM   2941 H HD3  . PRO A 1 192 ? 15.81867 18.73673  26.80330  1.000 21.46775  ? 187 PRO A HD3  1 
ATOM   2942 N N    . GLU A 1 193 ? 12.96189 22.14365  25.69789  1.000 14.36081  ? 188 GLU A N    1 
ATOM   2943 C CA   . GLU A 1 193 ? 12.07303 23.29538  25.60539  1.000 22.44697  ? 188 GLU A CA   1 
ATOM   2944 C C    . GLU A 1 193 ? 12.65893 24.36410  24.69063  1.000 21.05336  ? 188 GLU A C    1 
ATOM   2945 O O    . GLU A 1 193 ? 11.91615 25.00162  23.93337  1.000 22.35674  ? 188 GLU A O    1 
ATOM   2946 C CB   . GLU A 1 193 ? 11.78702 23.84309  27.00621  1.000 24.82499  ? 188 GLU A CB   1 
ATOM   2947 C CG   . GLU A 1 193 ? 10.75096 22.99497  27.79068  1.000 45.56194  ? 188 GLU A CG   1 
ATOM   2948 C CD   . GLU A 1 193 ? 10.49234 23.49454  29.22446  1.000 38.46293  ? 188 GLU A CD   1 
ATOM   2949 O OE1  . GLU A 1 193 ? 11.47116 23.95772  29.84839  1.000 19.79391  ? 188 GLU A OE1  1 
ATOM   2950 O OE2  . GLU A 1 193 ? 9.32618  23.41430  29.72223  1.000 38.57955  ? 188 GLU A OE2  1 
ATOM   2951 H H    . GLU A 1 193 ? 13.43241 22.10499  26.41672  1.000 17.25537  ? 188 GLU A H    1 
ATOM   2952 H HA   . GLU A 1 193 ? 11.22203 23.02449  25.22680  1.000 26.95876  ? 188 GLU A HA   1 
ATOM   2953 H HB2  . GLU A 1 193 ? 12.61283 23.85214  27.51499  1.000 29.81239  ? 188 GLU A HB2  1 
ATOM   2954 H HB3  . GLU A 1 193 ? 11.43679 24.74410  26.92613  1.000 29.81239  ? 188 GLU A HB3  1 
ATOM   2955 H HG2  . GLU A 1 193 ? 9.90632  23.01584  27.31418  1.000 54.69673  ? 188 GLU A HG2  1 
ATOM   2956 H HG3  . GLU A 1 193 ? 11.07585 22.08294  27.85018  1.000 54.69673  ? 188 GLU A HG3  1 
ATOM   2957 N N    . GLU A 1 194 ? 13.98030 24.57435  24.73095  1.000 24.16615  ? 189 GLU A N    1 
ATOM   2958 C CA   . GLU A 1 194 ? 14.64425 25.32523  23.65843  1.000 22.98844  ? 189 GLU A CA   1 
ATOM   2959 C C    . GLU A 1 194 ? 14.26549 24.77726  22.27387  1.000 26.09509  ? 189 GLU A C    1 
ATOM   2960 O O    . GLU A 1 194 ? 13.86832 25.52846  21.37662  1.000 11.52542  ? 189 GLU A O    1 
ATOM   2961 C CB   . GLU A 1 194 ? 16.16261 25.26399  23.86536  1.000 15.62173  ? 189 GLU A CB   1 
ATOM   2962 C CG   . GLU A 1 194 ? 17.06417 26.26154  23.05934  1.000 10.14478  ? 189 GLU A CG   1 
ATOM   2963 C CD   . GLU A 1 194 ? 16.78513 27.74180  23.35467  1.000 23.99375  ? 189 GLU A CD   1 
ATOM   2964 O OE1  . GLU A 1 194 ? 16.07670 28.03615  24.33924  1.000 17.44199  ? 189 GLU A OE1  1 
ATOM   2965 O OE2  . GLU A 1 194 ? 17.26240 28.61493  22.57739  1.000 17.74039  ? 189 GLU A OE2  1 
ATOM   2966 H H    . GLU A 1 194 ? 14.50440 24.29891  25.35468  1.000 29.02178  ? 189 GLU A H    1 
ATOM   2967 H HA   . GLU A 1 194 ? 14.36130 26.25227  23.69639  1.000 27.60853  ? 189 GLU A HA   1 
ATOM   2968 H HB2  . GLU A 1 194 ? 16.33812 25.43012  24.80477  1.000 18.76848  ? 189 GLU A HB2  1 
ATOM   2969 H HB3  . GLU A 1 194 ? 16.45607 24.37100  23.62589  1.000 18.76848  ? 189 GLU A HB3  1 
ATOM   2970 H HG2  . GLU A 1 194 ? 17.99279 26.08809  23.27952  1.000 12.19614  ? 189 GLU A HG2  1 
ATOM   2971 H HG3  . GLU A 1 194 ? 16.91554 26.11802  22.11161  1.000 12.19614  ? 189 GLU A HG3  1 
ATOM   2972 N N    . ALA A 1 195 ? 14.40319 23.45886  22.07655  1.000 22.36502  ? 190 ALA A N    1 
ATOM   2973 C CA   . ALA A 1 195 ? 14.07528 22.86192  20.78437  1.000 19.76671  ? 190 ALA A CA   1 
ATOM   2974 C C    . ALA A 1 195 ? 12.66168 23.21866  20.34135  1.000 20.77715  ? 190 ALA A C    1 
ATOM   2975 O O    . ALA A 1 195 ? 12.40793 23.47607  19.16117  1.000 16.30713  ? 190 ALA A O    1 
ATOM   2976 C CB   . ALA A 1 195 ? 14.22184 21.34763  20.85016  1.000 11.65228  ? 190 ALA A CB   1 
ATOM   2977 H H    . ALA A 1 195 ? 14.68066 22.89955  22.66797  1.000 26.86043  ? 190 ALA A H    1 
ATOM   2978 H HA   . ALA A 1 195 ? 14.70002 23.20627  20.12709  1.000 23.74245  ? 190 ALA A HA   1 
ATOM   2979 H HB1  . ALA A 1 195 ? 14.08257 20.97808  19.96419  1.000 14.00514  ? 190 ALA A HB1  1 
ATOM   2980 H HB2  . ALA A 1 195 ? 15.11389 21.12998  21.16287  1.000 14.00514  ? 190 ALA A HB2  1 
ATOM   2981 H HB3  . ALA A 1 195 ? 13.56026 20.99271  21.46436  1.000 14.00514  ? 190 ALA A HB3  1 
ATOM   2982 N N    . ILE A 1 196 ? 11.72897 23.25501  21.28356  1.000 28.52405  ? 191 ILE A N    1 
ATOM   2983 C CA   . ILE A 1 196 ? 10.33469 23.49296  20.94433  1.000 16.24359  ? 191 ILE A CA   1 
ATOM   2984 C C    . ILE A 1 196 ? 10.08690 24.96532  20.62793  1.000 16.54865  ? 191 ILE A C    1 
ATOM   2985 O O    . ILE A 1 196 ? 9.29343  25.29634  19.74297  1.000 16.21513  ? 191 ILE A O    1 
ATOM   2986 C CB   . ILE A 1 196 ? 9.46150  22.98632  22.10181  1.000 32.49526  ? 191 ILE A CB   1 
ATOM   2987 C CG1  . ILE A 1 196 ? 9.55588  21.46637  22.21893  1.000 28.63340  ? 191 ILE A CG1  1 
ATOM   2988 C CG2  . ILE A 1 196 ? 8.02197  23.32370  21.92892  1.000 7.82086   ? 191 ILE A CG2  1 
ATOM   2989 C CD1  . ILE A 1 196 ? 8.54179  20.88804  23.17620  1.000 26.59120  ? 191 ILE A CD1  1 
ATOM   2990 H H    . ILE A 1 196 ? 11.87631 23.14535  22.12372  1.000 34.25126  ? 191 ILE A H    1 
ATOM   2991 H HA   . ILE A 1 196 ? 10.10511 23.00003  20.14109  1.000 19.51471  ? 191 ILE A HA   1 
ATOM   2992 H HB   . ILE A 1 196 ? 9.80196  23.42702  22.89602  1.000 39.01671  ? 191 ILE A HB   1 
ATOM   2993 H HG12 . ILE A 1 196 ? 9.40265  21.07265  21.34577  1.000 34.38248  ? 191 ILE A HG12 1 
ATOM   2994 H HG13 . ILE A 1 196 ? 10.44014 21.22904  22.53932  1.000 34.38248  ? 191 ILE A HG13 1 
ATOM   2995 H HG21 . ILE A 1 196 ? 7.60388  23.38078  22.80233  1.000 9.40743   ? 191 ILE A HG21 1 
ATOM   2996 H HG22 . ILE A 1 196 ? 7.95010  24.17603  21.47146  1.000 9.40743   ? 191 ILE A HG22 1 
ATOM   2997 H HG23 . ILE A 1 196 ? 7.59576  22.62901  21.40294  1.000 9.40743   ? 191 ILE A HG23 1 
ATOM   2998 H HD11 . ILE A 1 196 ? 8.81783  19.99217  23.42544  1.000 31.93184  ? 191 ILE A HD11 1 
ATOM   2999 H HD12 . ILE A 1 196 ? 8.49484  21.45109  23.96467  1.000 31.93184  ? 191 ILE A HD12 1 
ATOM   3000 H HD13 . ILE A 1 196 ? 7.67631  20.85794  22.73922  1.000 31.93184  ? 191 ILE A HD13 1 
ATOM   3001 N N    . SER A 1 197 ? 10.75594 25.88531  21.31467  1.000 17.22997  ? 192 SER A N    1 
ATOM   3002 C CA   . SER A 1 197 ? 10.52916 27.29628  21.00574  1.000 13.43385  ? 192 SER A CA   1 
ATOM   3003 C C    . SER A 1 197 ? 11.05610 27.62834  19.61354  1.000 25.97841  ? 192 SER A C    1 
ATOM   3004 O O    . SER A 1 197 ? 10.38544 28.31433  18.83585  1.000 26.15630  ? 192 SER A O    1 
ATOM   3005 C CB   . SER A 1 197 ? 11.16748 28.17688  22.08826  1.000 29.88363  ? 192 SER A CB   1 
ATOM   3006 O OG   . SER A 1 197 ? 10.92430 29.56807  21.88086  1.000 34.90033  ? 192 SER A OG   1 
ATOM   3007 H H    . SER A 1 197 ? 11.32484 25.72814  21.94016  1.000 20.69837  ? 192 SER A H    1 
ATOM   3008 H HA   . SER A 1 197 ? 9.57840  27.48840  21.01178  1.000 16.14302  ? 192 SER A HA   1 
ATOM   3009 H HB2  . SER A 1 197 ? 10.79785 27.92424  22.94875  1.000 35.88276  ? 192 SER A HB2  1 
ATOM   3010 H HB3  . SER A 1 197 ? 12.12583 28.02715  22.08199  1.000 35.88276  ? 192 SER A HB3  1 
ATOM   3011 H HG   . SER A 1 197 ? 11.20689 29.79948  21.12442  1.000 41.90279  ? 192 SER A HG   1 
ATOM   3012 N N    . LEU A 1 198 ? 12.22680 27.10371  19.26314  1.000 13.96567  ? 193 LEU A N    1 
ATOM   3013 C CA   . LEU A 1 198 ? 12.80651 27.41711  17.96275  1.000 18.49084  ? 193 LEU A CA   1 
ATOM   3014 C C    . LEU A 1 198 ? 11.90544 26.95900  16.81391  1.000 14.58043  ? 193 LEU A C    1 
ATOM   3015 O O    . LEU A 1 198 ? 11.70344 27.69829  15.85057  1.000 16.04334  ? 193 LEU A O    1 
ATOM   3016 C CB   . LEU A 1 198 ? 14.20035 26.79372  17.85798  1.000 22.04388  ? 193 LEU A CB   1 
ATOM   3017 C CG   . LEU A 1 198 ? 14.91148 27.00900  16.51707  1.000 31.94454  ? 193 LEU A CG   1 
ATOM   3018 C CD1  . LEU A 1 198 ? 14.96437 28.49801  16.11078  1.000 23.12063  ? 193 LEU A CD1  1 
ATOM   3019 C CD2  . LEU A 1 198 ? 16.27871 26.42391  16.64117  1.000 23.61376  ? 193 LEU A CD2  1 
ATOM   3020 H H    . LEU A 1 198 ? 12.69701 26.57357  19.75043  1.000 16.78120  ? 193 LEU A H    1 
ATOM   3021 H HA   . LEU A 1 198 ? 12.90057 28.37923  17.88283  1.000 22.21140  ? 193 LEU A HA   1 
ATOM   3022 H HB2  . LEU A 1 198 ? 14.76056 27.17957  18.54948  1.000 26.47505  ? 193 LEU A HB2  1 
ATOM   3023 H HB3  . LEU A 1 198 ? 14.11815 25.83671  17.99319  1.000 26.47505  ? 193 LEU A HB3  1 
ATOM   3024 H HG   . LEU A 1 198 ? 14.42221 26.57209  15.80249  1.000 38.35585  ? 193 LEU A HG   1 
ATOM   3025 H HD11 . LEU A 1 198 ? 15.69816 28.63019  15.49031  1.000 27.76715  ? 193 LEU A HD11 1 
ATOM   3026 H HD12 . LEU A 1 198 ? 14.12572 28.73988  15.68761  1.000 27.76715  ? 193 LEU A HD12 1 
ATOM   3027 H HD13 . LEU A 1 198 ? 15.10168 29.03743  16.90519  1.000 27.76715  ? 193 LEU A HD13 1 
ATOM   3028 H HD21 . LEU A 1 198 ? 16.20057 25.48304  16.86377  1.000 28.35891  ? 193 LEU A HD21 1 
ATOM   3029 H HD22 . LEU A 1 198 ? 16.74395 26.52638  15.79621  1.000 28.35891  ? 193 LEU A HD22 1 
ATOM   3030 H HD23 . LEU A 1 198 ? 16.75960 26.89087  17.34231  1.000 28.35891  ? 193 LEU A HD23 1 
ATOM   3031 N N    . ALA A 1 199 ? 11.34940 25.74826  16.89305  1.000 16.71064  ? 194 ALA A N    1 
ATOM   3032 C CA   . ALA A 1 199 ? 10.63032 25.20417  15.74374  1.000 26.45934  ? 194 ALA A CA   1 
ATOM   3033 C C    . ALA A 1 199 ? 9.33122  25.94561  15.49651  1.000 23.65839  ? 194 ALA A C    1 
ATOM   3034 O O    . ALA A 1 199 ? 8.88637  26.02036  14.34853  1.000 19.24318  ? 194 ALA A O    1 
ATOM   3035 C CB   . ALA A 1 199 ? 10.33214 23.71599  15.93951  1.000 21.46044  ? 194 ALA A CB   1 
ATOM   3036 H H    . ALA A 1 199 ? 11.37383 25.23546  17.58301  1.000 20.07517  ? 194 ALA A H    1 
ATOM   3037 H HA   . ALA A 1 199 ? 11.20145 25.29783  14.96532  1.000 31.77360  ? 194 ALA A HA   1 
ATOM   3038 H HB1  . ALA A 1 199 ? 9.82507  23.60056  16.75832  1.000 25.77493  ? 194 ALA A HB1  1 
ATOM   3039 H HB2  . ALA A 1 199 ? 9.81659  23.39504  15.18314  1.000 25.77493  ? 194 ALA A HB2  1 
ATOM   3040 H HB3  . ALA A 1 199 ? 11.17017 23.23106  15.99827  1.000 25.77493  ? 194 ALA A HB3  1 
ATOM   3041 N N    . LYS A 1 200 ? 8.72834  26.49293  16.57049  1.000 33.00953  ? 195 LYS A N    1 
ATOM   3042 C CA   . LYS A 1 200 ? 7.45280  27.21079  16.53698  1.000 25.26918  ? 195 LYS A CA   1 
ATOM   3043 C C    . LYS A 1 200 ? 7.62144  28.64856  16.06047  1.000 19.88607  ? 195 LYS A C    1 
ATOM   3044 O O    . LYS A 1 200 ? 6.81648  29.13862  15.25216  1.000 9.30651   ? 195 LYS A O    1 
ATOM   3045 C CB   . LYS A 1 200 ? 6.82087  27.17088  17.93577  1.000 22.02869  ? 195 LYS A CB   1 
ATOM   3046 C CG   . LYS A 1 200 ? 5.78525  28.24358  18.19769  1.000 34.74927  ? 195 LYS A CG   1 
ATOM   3047 C CD   . LYS A 1 200 ? 4.57276  27.72710  18.97066  1.000 31.02002  ? 195 LYS A CD   1 
ATOM   3048 C CE   . LYS A 1 200 ? 3.36201  28.70980  18.87032  1.000 39.92286  ? 195 LYS A CE   1 
ATOM   3049 N NZ   . LYS A 1 200 ? 2.45768  28.52707  17.65327  1.000 41.34827  ? 195 LYS A NZ   1 
ATOM   3050 H H    . LYS A 1 200 ? 9.05723  26.45772  17.36434  1.000 39.63383  ? 195 LYS A H    1 
ATOM   3051 H HA   . LYS A 1 200 ? 6.85308  26.77228  15.91332  1.000 30.34541  ? 195 LYS A HA   1 
ATOM   3052 H HB2  . LYS A 1 200 ? 6.38617  26.31160  18.05233  1.000 26.45683  ? 195 LYS A HB2  1 
ATOM   3053 H HB3  . LYS A 1 200 ? 7.52485  27.27858  18.59434  1.000 26.45683  ? 195 LYS A HB3  1 
ATOM   3054 H HG2  . LYS A 1 200 ? 6.19131  28.95358  18.71914  1.000 41.72152  ? 195 LYS A HG2  1 
ATOM   3055 H HG3  . LYS A 1 200 ? 5.47141  28.59311  17.34903  1.000 41.72152  ? 195 LYS A HG3  1 
ATOM   3056 H HD2  . LYS A 1 200 ? 4.30047  26.87092  18.60500  1.000 37.24642  ? 195 LYS A HD2  1 
ATOM   3057 H HD3  . LYS A 1 200 ? 4.80754  27.62855  19.90664  1.000 37.24642  ? 195 LYS A HD3  1 
ATOM   3058 H HE2  . LYS A 1 200 ? 2.80895  28.59333  19.65865  1.000 47.92984  ? 195 LYS A HE2  1 
ATOM   3059 H HE3  . LYS A 1 200 ? 3.70688  29.61585  18.83792  1.000 47.92984  ? 195 LYS A HE3  1 
ATOM   3060 H HZ1  . LYS A 1 200 ? 2.91428  28.69176  16.90729  1.000 49.64033  ? 195 LYS A HZ1  1 
ATOM   3061 H HZ2  . LYS A 1 200 ? 2.14996  27.69243  17.62526  1.000 49.64033  ? 195 LYS A HZ2  1 
ATOM   3062 H HZ3  . LYS A 1 200 ? 1.76805  29.08776  17.69954  1.000 49.64033  ? 195 LYS A HZ3  1 
ATOM   3063 N N    . THR A 1 201 ? 8.64323  29.33988  16.57447  1.000 21.04433  ? 196 THR A N    1 
ATOM   3064 C CA   . THR A 1 201 ? 9.05084  30.62139  16.01047  1.000 15.84858  ? 196 THR A CA   1 
ATOM   3065 C C    . THR A 1 201 ? 9.39533  30.49988  14.52156  1.000 20.83171  ? 196 THR A C    1 
ATOM   3066 O O    . THR A 1 201 ? 8.98425  31.34099  13.71570  1.000 10.15392  ? 196 THR A O    1 
ATOM   3067 C CB   . THR A 1 201 ? 10.24018 31.17322  16.81188  1.000 21.09778  ? 196 THR A CB   1 
ATOM   3068 O OG1  . THR A 1 201 ? 9.87634  31.35476  18.18654  1.000 29.10478  ? 196 THR A OG1  1 
ATOM   3069 C CG2  . THR A 1 201 ? 10.67574 32.51793  16.26648  1.000 39.71963  ? 196 THR A CG2  1 
ATOM   3070 H H    . THR A 1 201 ? 9.11414  29.08716  17.24824  1.000 25.27560  ? 196 THR A H    1 
ATOM   3071 H HA   . THR A 1 201 ? 8.31630  31.25083  16.08229  1.000 19.04069  ? 196 THR A HA   1 
ATOM   3072 H HB   . THR A 1 201 ? 10.97292 30.54130  16.74346  1.000 25.33973  ? 196 THR A HB   1 
ATOM   3073 H HG1  . THR A 1 201 ? 9.87017  30.61388  18.58235  1.000 34.94813  ? 196 THR A HG1  1 
ATOM   3074 H HG21 . THR A 1 201 ? 11.33778 32.91538  16.85354  1.000 47.68595  ? 196 THR A HG21 1 
ATOM   3075 H HG22 . THR A 1 201 ? 11.06293 32.40835  15.38389  1.000 47.68595  ? 196 THR A HG22 1 
ATOM   3076 H HG23 . THR A 1 201 ? 9.91263  33.11344  16.20374  1.000 47.68595  ? 196 THR A HG23 1 
ATOM   3077 N N    . THR A 1 202 ? 10.15274 29.46529  14.14090  1.000 11.33619  ? 197 THR A N    1 
ATOM   3078 C CA   . THR A 1 202 ? 10.56934 29.30465  12.75235  1.000 17.17774  ? 197 THR A CA   1 
ATOM   3079 C C    . THR A 1 202 ? 9.35316  29.07997  11.84632  1.000 15.48251  ? 197 THR A C    1 
ATOM   3080 O O    . THR A 1 202 ? 9.17408  29.77075  10.85098  1.000 11.08510  ? 197 THR A O    1 
ATOM   3081 C CB   . THR A 1 202 ? 11.58047 28.14271  12.64731  1.000 21.85095  ? 197 THR A CB   1 
ATOM   3082 O OG1  . THR A 1 202 ? 12.75507 28.40981  13.43959  1.000 16.05206  ? 197 THR A OG1  1 
ATOM   3083 C CG2  . THR A 1 202 ? 12.01872 27.91547  11.20696  1.000 14.57317  ? 197 THR A CG2  1 
ATOM   3084 H H    . THR A 1 202 ? 10.43583 28.84697  14.66734  1.000 13.62583  ? 197 THR A H    1 
ATOM   3085 H HA   . THR A 1 202 ? 11.01623 30.11009  12.44830  1.000 20.63568  ? 197 THR A HA   1 
ATOM   3086 H HB   . THR A 1 202 ? 11.14217 27.34143  12.97403  1.000 26.24355  ? 197 THR A HB   1 
ATOM   3087 H HG1  . THR A 1 202 ? 12.67269 28.06460  14.20093  1.000 19.28487  ? 197 THR A HG1  1 
ATOM   3088 H HG21 . THR A 1 202 ? 12.77693 27.31098  11.18232  1.000 17.51020  ? 197 THR A HG21 1 
ATOM   3089 H HG22 . THR A 1 202 ? 11.29081 27.52842  10.69584  1.000 17.51020  ? 197 THR A HG22 1 
ATOM   3090 H HG23 . THR A 1 202 ? 12.27488 28.75846  10.80120  1.000 17.51020  ? 197 THR A HG23 1 
ATOM   3091 N N    . PHE A 1 203 ? 8.47622  28.14647  12.21775  1.000 23.91214  ? 198 PHE A N    1 
ATOM   3092 C CA   . PHE A 1 203 ? 7.27044  27.88970  11.43035  1.000 20.23563  ? 198 PHE A CA   1 
ATOM   3093 C C    . PHE A 1 203 ? 6.42491  29.15490  11.24732  1.000 19.75679  ? 198 PHE A C    1 
ATOM   3094 O O    . PHE A 1 203 ? 5.88584  29.40872  10.15583  1.000 21.77386  ? 198 PHE A O    1 
ATOM   3095 C CB   . PHE A 1 203 ? 6.45272  26.78021  12.12523  1.000 16.60150  ? 198 PHE A CB   1 
ATOM   3096 C CG   . PHE A 1 203 ? 5.31464  26.20568  11.28589  1.000 15.23056  ? 198 PHE A CG   1 
ATOM   3097 C CD1  . PHE A 1 203 ? 4.10442  26.85737  11.20633  1.000 20.08712  ? 198 PHE A CD1  1 
ATOM   3098 C CD2  . PHE A 1 203 ? 5.44784  24.99488  10.62692  1.000 18.85011  ? 198 PHE A CD2  1 
ATOM   3099 C CE1  . PHE A 1 203 ? 3.05776  26.33215  10.45862  1.000 23.51786  ? 198 PHE A CE1  1 
ATOM   3100 C CE2  . PHE A 1 203 ? 4.41200  24.46671  9.89646   1.000 22.86669  ? 198 PHE A CE2  1 
ATOM   3101 C CZ   . PHE A 1 203 ? 3.21481  25.14608  9.79281   1.000 20.40682  ? 198 PHE A CZ   1 
ATOM   3102 H H    . PHE A 1 203 ? 8.55450  27.65102  12.91632  1.000 28.71697  ? 198 PHE A H    1 
ATOM   3103 H HA   . PHE A 1 203 ? 7.52440  27.58934  10.54368  1.000 24.30515  ? 198 PHE A HA   1 
ATOM   3104 H HB2  . PHE A 1 203 ? 7.05066  26.04901  12.34596  1.000 19.94420  ? 198 PHE A HB2  1 
ATOM   3105 H HB3  . PHE A 1 203 ? 6.06279  27.14581  12.93467  1.000 19.94420  ? 198 PHE A HB3  1 
ATOM   3106 H HD1  . PHE A 1 203 ? 3.98583  27.66071  11.65963  1.000 24.12694  ? 198 PHE A HD1  1 
ATOM   3107 H HD2  . PHE A 1 203 ? 6.25252  24.53166  10.68004  1.000 22.64253  ? 198 PHE A HD2  1 
ATOM   3108 H HE1  . PHE A 1 203 ? 2.24828  26.78744  10.41025  1.000 28.24383  ? 198 PHE A HE1  1 
ATOM   3109 H HE2  . PHE A 1 203 ? 4.51751  23.64728  9.46949   1.000 27.46243  ? 198 PHE A HE2  1 
ATOM   3110 H HZ   . PHE A 1 203 ? 2.52231  24.80185  9.27624   1.000 24.51058  ? 198 PHE A HZ   1 
ATOM   3111 N N    . ASP A 1 204 ? 6.25398  29.93468  12.31066  1.000 31.92342  ? 199 ASP A N    1 
ATOM   3112 C CA   . ASP A 1 204 ? 5.30904  31.05356  12.28842  1.000 25.24516  ? 199 ASP A CA   1 
ATOM   3113 C C    . ASP A 1 204 ? 5.78091  32.18910  11.36951  1.000 13.50560  ? 199 ASP A C    1 
ATOM   3114 O O    . ASP A 1 204 ? 4.98471  32.79921  10.65343  1.000 19.93517  ? 199 ASP A O    1 
ATOM   3115 C CB   . ASP A 1 204 ? 5.12777  31.58827  13.70959  1.000 25.12959  ? 199 ASP A CB   1 
ATOM   3116 C CG   . ASP A 1 204 ? 4.18071  30.75288  14.55251  1.000 25.91625  ? 199 ASP A CG   1 
ATOM   3117 O OD1  . ASP A 1 204 ? 3.40726  29.96220  13.99444  1.000 32.76287  ? 199 ASP A OD1  1 
ATOM   3118 O OD2  . ASP A 1 204 ? 4.19935  30.90908  15.79327  1.000 24.76794  ? 199 ASP A OD2  1 
ATOM   3119 H H    . ASP A 1 204 ? 6.67000  29.84075  13.05745  1.000 38.33051  ? 199 ASP A H    1 
ATOM   3120 H HA   . ASP A 1 204 ? 4.45912  30.73013  11.95088  1.000 30.31659  ? 199 ASP A HA   1 
ATOM   3121 H HB2  . ASP A 1 204 ? 5.99030  31.59813  14.15328  1.000 30.17791  ? 199 ASP A HB2  1 
ATOM   3122 H HB3  . ASP A 1 204 ? 4.76856  32.48808  13.66260  1.000 30.17791  ? 199 ASP A HB3  1 
ATOM   3123 N N    . GLU A 1 205 ? 7.07030  32.48997  11.37925  1.000 22.74167  ? 200 GLU A N    1 
ATOM   3124 C CA   . GLU A 1 205 ? 7.58294  33.59324  10.56843  1.000 10.75117  ? 200 GLU A CA   1 
ATOM   3125 C C    . GLU A 1 205 ? 7.64155  33.23802  9.07881   1.000 34.07733  ? 200 GLU A C    1 
ATOM   3126 O O    . GLU A 1 205 ? 7.45288  34.11638  8.23873   1.000 37.03111  ? 200 GLU A O    1 
ATOM   3127 C CB   . GLU A 1 205 ? 8.96091  34.00619  11.11012  1.000 16.27897  ? 200 GLU A CB   1 
ATOM   3128 C CG   . GLU A 1 205 ? 8.94001  34.67297  12.53834  1.000 22.33591  ? 200 GLU A CG   1 
ATOM   3129 C CD   . GLU A 1 205 ? 10.29757 35.22246  13.02216  1.000 66.63419  ? 200 GLU A CD   1 
ATOM   3130 O OE1  . GLU A 1 205 ? 11.32060 35.21972  12.28762  1.000 44.05588  ? 200 GLU A OE1  1 
ATOM   3131 O OE2  . GLU A 1 205 ? 10.33830 35.64360  14.19360  1.000 66.90605  ? 200 GLU A OE2  1 
ATOM   3132 H H    . GLU A 1 205 ? 7.66802  32.07809  11.84042  1.000 27.31240  ? 200 GLU A H    1 
ATOM   3133 H HA   . GLU A 1 205 ? 6.98919  34.35691  10.64025  1.000 12.92380  ? 200 GLU A HA   1 
ATOM   3134 H HB2  . GLU A 1 205 ? 9.51885  33.21470  11.16635  1.000 19.55717  ? 200 GLU A HB2  1 
ATOM   3135 H HB3  . GLU A 1 205 ? 9.35356  34.64592  10.49574  1.000 19.55717  ? 200 GLU A HB3  1 
ATOM   3136 H HG2  . GLU A 1 205 ? 8.31577  35.41523  12.52182  1.000 26.82550  ? 200 GLU A HG2  1 
ATOM   3137 H HG3  . GLU A 1 205 ? 8.64920  34.00920  13.18313  1.000 26.82550  ? 200 GLU A HG3  1 
ATOM   3138 N N    . ALA A 1 206 ? 7.88869  31.96884  8.72139   1.000 17.66447  ? 201 ALA A N    1 
ATOM   3139 C CA   . ALA A 1 206 ? 7.73647  31.57351  7.32795   1.000 10.27525  ? 201 ALA A CA   1 
ATOM   3140 C C    . ALA A 1 206 ? 6.26955  31.62589  6.88719   1.000 17.01021  ? 201 ALA A C    1 
ATOM   3141 O O    . ALA A 1 206 ? 5.96192  32.14055  5.80115   1.000 16.26286  ? 201 ALA A O    1 
ATOM   3142 C CB   . ALA A 1 206 ? 8.32122  30.18054  7.07803   1.000 14.44327  ? 201 ALA A CB   1 
ATOM   3143 H H    . ALA A 1 206 ? 8.13769  31.34182  9.25472   1.000 21.21976  ? 201 ALA A H    1 
ATOM   3144 H HA   . ALA A 1 206 ? 8.24111  32.20179  6.78803   1.000 12.35270  ? 201 ALA A HA   1 
ATOM   3145 H HB1  . ALA A 1 206 ? 8.28313  29.98782  6.12813   1.000 17.35433  ? 201 ALA A HB1  1 
ATOM   3146 H HB2  . ALA A 1 206 ? 9.24226  30.16550  7.38192   1.000 17.35433  ? 201 ALA A HB2  1 
ATOM   3147 H HB3  . ALA A 1 206 ? 7.80005  29.52645  7.56941   1.000 17.35433  ? 201 ALA A HB3  1 
ATOM   3148 N N    . MET A 1 207 ? 5.35788  31.05507  7.68010   1.000 12.34639  ? 202 MET A N    1 
ATOM   3149 C CA   . MET A 1 207 ? 3.92945  31.05481  7.32570   1.000 20.25901  ? 202 MET A CA   1 
ATOM   3150 C C    . MET A 1 207 ? 3.48941  32.42976  6.81649   1.000 19.11145  ? 202 MET A C    1 
ATOM   3151 O O    . MET A 1 207 ? 2.92951  32.55728  5.73107   1.000 23.71390  ? 202 MET A O    1 
ATOM   3152 C CB   . MET A 1 207 ? 3.08749  30.63294  8.55809   1.000 12.65426  ? 202 MET A CB   1 
ATOM   3153 C CG   . MET A 1 207 ? 1.56568  30.81260  8.45942   1.000 43.59020  ? 202 MET A CG   1 
ATOM   3154 S SD   . MET A 1 207 ? 0.61078  29.65719  7.39319   1.000 66.90562  ? 202 MET A SD   1 
ATOM   3155 C CE   . MET A 1 207 ? 1.77594  28.35141  7.09906   1.000 5.13163   ? 202 MET A CE   1 
ATOM   3156 H H    . MET A 1 207 ? 5.53586  30.66298  8.42454   1.000 14.83807  ? 202 MET A H    1 
ATOM   3157 H HA   . MET A 1 207 ? 3.77918  30.39936  6.62662   1.000 24.33321  ? 202 MET A HA   1 
ATOM   3158 H HB2  . MET A 1 207 ? 3.25001  29.69094  8.72278   1.000 15.20751  ? 202 MET A HB2  1 
ATOM   3159 H HB3  . MET A 1 207 ? 3.38473  31.15856  9.31721   1.000 15.20751  ? 202 MET A HB3  1 
ATOM   3160 H HG2  . MET A 1 207 ? 1.20132  30.72557  9.35416   1.000 52.33064  ? 202 MET A HG2  1 
ATOM   3161 H HG3  . MET A 1 207 ? 1.39707  31.70468  8.11786   1.000 52.33064  ? 202 MET A HG3  1 
ATOM   3162 H HE1  . MET A 1 207 ? 1.35595  27.67123  6.54964   1.000 6.18036   ? 202 MET A HE1  1 
ATOM   3163 H HE2  . MET A 1 207 ? 2.54943  28.71564  6.64085   1.000 6.18036   ? 202 MET A HE2  1 
ATOM   3164 H HE3  . MET A 1 207 ? 2.04448  27.97025  7.94964   1.000 6.18036   ? 202 MET A HE3  1 
ATOM   3165 N N    . ALA A 1 208 ? 3.76055  33.47466  7.59122   1.000 21.75450  ? 203 ALA A N    1 
ATOM   3166 C CA   . ALA A 1 208 ? 3.32356  34.81740  7.26120   1.000 28.58951  ? 203 ALA A CA   1 
ATOM   3167 C C    . ALA A 1 208 ? 4.09822  35.44154  6.10893   1.000 29.26066  ? 203 ALA A C    1 
ATOM   3168 O O    . ALA A 1 208 ? 3.80565  36.59030  5.76526   1.000 29.71521  ? 203 ALA A O    1 
ATOM   3169 C CB   . ALA A 1 208 ? 3.43183  35.68745  8.51281   1.000 17.15800  ? 203 ALA A CB   1 
ATOM   3170 H H    . ALA A 1 208 ? 4.20454  33.42748  8.32624   1.000 26.12780  ? 203 ALA A H    1 
ATOM   3171 H HA   . ALA A 1 208 ? 2.39479  34.79248  6.98252   1.000 34.32981  ? 203 ALA A HA   1 
ATOM   3172 H HB1  . ALA A 1 208 ? 2.90992  35.28401  9.22397   1.000 20.61200  ? 203 ALA A HB1  1 
ATOM   3173 H HB2  . ALA A 1 208 ? 4.36315  35.74505  8.77778   1.000 20.61200  ? 203 ALA A HB2  1 
ATOM   3174 H HB3  . ALA A 1 208 ? 3.08952  36.57269  8.31262   1.000 20.61200  ? 203 ALA A HB3  1 
ATOM   3175 N N    . ASP A 1 209 ? 5.03012  34.71568  5.47888   1.000 38.97996  ? 204 ASP A N    1 
ATOM   3176 C CA   . ASP A 1 209 ? 5.76604  35.18264  4.29711   1.000 37.51611  ? 204 ASP A CA   1 
ATOM   3177 C C    . ASP A 1 209 ? 5.38012  34.46777  2.99009   1.000 30.00674  ? 204 ASP A C    1 
ATOM   3178 O O    . ASP A 1 209 ? 5.87546  34.84023  1.92168   1.000 14.06580  ? 204 ASP A O    1 
ATOM   3179 C CB   . ASP A 1 209 ? 7.27979  35.01016  4.53963   1.000 43.79934  ? 204 ASP A CB   1 
ATOM   3180 C CG   . ASP A 1 209 ? 8.11871  36.14963  3.96572   1.000 50.13796  ? 204 ASP A CG   1 
ATOM   3181 O OD1  . ASP A 1 209 ? 7.91605  37.31189  4.38294   1.000 60.66753  ? 204 ASP A OD1  1 
ATOM   3182 O OD2  . ASP A 1 209 ? 8.99010  35.88505  3.10752   1.000 41.24500  ? 204 ASP A OD2  1 
ATOM   3183 H H    . ASP A 1 209 ? 5.26086  33.92462  5.72502   1.000 46.79835  ? 204 ASP A H    1 
ATOM   3184 H HA   . ASP A 1 209 ? 5.56664  36.12361  4.17176   1.000 45.04173  ? 204 ASP A HA   1 
ATOM   3185 H HB2  . ASP A 1 209 ? 7.44226  34.97337  5.49522   1.000 52.58160  ? 204 ASP A HB2  1 
ATOM   3186 H HB3  . ASP A 1 209 ? 7.57260  34.18543  4.12133   1.000 52.58160  ? 204 ASP A HB3  1 
ATOM   3187 N N    . LEU A 1 210 ? 4.50256  33.45862  3.02926   1.000 29.91738  ? 205 LEU A N    1 
ATOM   3188 C CA   . LEU A 1 210 ? 4.24017  32.66740  1.82374   1.000 31.17355  ? 205 LEU A CA   1 
ATOM   3189 C C    . LEU A 1 210 ? 3.60789  33.49162  0.69784   1.000 28.37905  ? 205 LEU A C    1 
ATOM   3190 O O    . LEU A 1 210 ? 3.82896  33.20719  -0.48927  1.000 19.42236  ? 205 LEU A O    1 
ATOM   3191 C CB   . LEU A 1 210 ? 3.34237  31.47276  2.18181   1.000 23.51544  ? 205 LEU A CB   1 
ATOM   3192 C CG   . LEU A 1 210 ? 3.98245  30.50764  3.19672   1.000 29.18625  ? 205 LEU A CG   1 
ATOM   3193 C CD1  . LEU A 1 210 ? 2.94596  29.53350  3.77473   1.000 19.57290  ? 205 LEU A CD1  1 
ATOM   3194 C CD2  . LEU A 1 210 ? 5.16951  29.71853  2.60732   1.000 21.47767  ? 205 LEU A CD2  1 
ATOM   3195 H H    . LEU A 1 210 ? 4.05683  33.21747  3.72408   1.000 35.92326  ? 205 LEU A H    1 
ATOM   3196 H HA   . LEU A 1 210 ? 5.08654  32.33413  1.48686   1.000 37.43066  ? 205 LEU A HA   1 
ATOM   3197 H HB2  . LEU A 1 210 ? 2.51729  31.80661  2.56739   1.000 28.24093  ? 205 LEU A HB2  1 
ATOM   3198 H HB3  . LEU A 1 210 ? 3.15188  30.97181  1.37332   1.000 28.24093  ? 205 LEU A HB3  1 
ATOM   3199 H HG   . LEU A 1 210 ? 4.33104  31.05713  3.91605   1.000 35.04590  ? 205 LEU A HG   1 
ATOM   3200 H HD11 . LEU A 1 210 ? 2.28793  30.03585  4.28025   1.000 23.50988  ? 205 LEU A HD11 1 
ATOM   3201 H HD12 . LEU A 1 210 ? 2.51364  29.06278  3.04506   1.000 23.50988  ? 205 LEU A HD12 1 
ATOM   3202 H HD13 . LEU A 1 210 ? 3.39673  28.90077  4.35556   1.000 23.50988  ? 205 LEU A HD13 1 
ATOM   3203 H HD21 . LEU A 1 210 ? 5.83266  30.34501  2.27772   1.000 25.79561  ? 205 LEU A HD21 1 
ATOM   3204 H HD22 . LEU A 1 210 ? 5.55583  29.16317  3.30247   1.000 25.79561  ? 205 LEU A HD22 1 
ATOM   3205 H HD23 . LEU A 1 210 ? 4.84914  29.16272  1.87976   1.000 25.79561  ? 205 LEU A HD23 1 
ATOM   3206 N N    . HIS A 1 211 ? 2.79609  34.49519  1.03590   1.000 22.01489  ? 206 HIS A N    1 
ATOM   3207 C CA   . HIS A 1 211 ? 2.09481  35.26231  0.00757   1.000 27.80962  ? 206 HIS A CA   1 
ATOM   3208 C C    . HIS A 1 211 ? 3.03081  35.90713  -1.02671  1.000 26.28096  ? 206 HIS A C    1 
ATOM   3209 O O    . HIS A 1 211 ? 2.54897  36.37906  -2.05911  1.000 17.56415  ? 206 HIS A O    1 
ATOM   3210 C CB   . HIS A 1 211 ? 1.24449  36.34605  0.68408   1.000 16.05219  ? 206 HIS A CB   1 
ATOM   3211 C CG   . HIS A 1 211 ? 2.05010  37.44870  1.31062   1.000 21.19843  ? 206 HIS A CG   1 
ATOM   3212 N ND1  . HIS A 1 211 ? 2.23705  37.55879  2.67479   1.000 29.95863  ? 206 HIS A ND1  1 
ATOM   3213 C CD2  . HIS A 1 211 ? 2.68850  38.50718  0.76367   1.000 24.61017  ? 206 HIS A CD2  1 
ATOM   3214 C CE1  . HIS A 1 211 ? 2.97918  38.61763  2.93641   1.000 25.58708  ? 206 HIS A CE1  1 
ATOM   3215 N NE2  . HIS A 1 211 ? 3.26735  39.21055  1.79331   1.000 33.55765  ? 206 HIS A NE2  1 
ATOM   3216 H H    . HIS A 1 211 ? 2.63694  34.74787  1.84239   1.000 26.44026  ? 206 HIS A H    1 
ATOM   3217 H HA   . HIS A 1 211 ? 1.51048  34.66114  -0.48033  1.000 33.39394  ? 206 HIS A HA   1 
ATOM   3218 H HB2  . HIS A 1 211 ? 0.66318  36.74626  0.01864   1.000 19.28503  ? 206 HIS A HB2  1 
ATOM   3219 H HB3  . HIS A 1 211 ? 0.71365  35.93385  1.38351   1.000 19.28503  ? 206 HIS A HB3  1 
ATOM   3220 H HD2  . HIS A 1 211 ? 2.72867  38.71999  -0.14076  1.000 29.55460  ? 206 HIS A HD2  1 
ATOM   3221 H HE1  . HIS A 1 211 ? 3.25200  38.89766  3.78024   1.000 30.72690  ? 206 HIS A HE1  1 
ATOM   3222 H HE2  . HIS A 1 211 ? 3.74132  39.92286  1.70636   1.000 40.29158  ? 206 HIS A HE2  1 
ATOM   3223 N N    . THR A 1 212 ? 4.34381  35.93337  -0.78515  1.000 21.94866  ? 207 THR A N    1 
ATOM   3224 C CA   . THR A 1 212 ? 5.27497  36.66244  -1.63027  1.000 28.76927  ? 207 THR A CA   1 
ATOM   3225 C C    . THR A 1 212 ? 5.93928  35.80022  -2.69571  1.000 32.32668  ? 207 THR A C    1 
ATOM   3226 O O    . THR A 1 212 ? 6.75183  36.32337  -3.45373  1.000 36.29191  ? 207 THR A O    1 
ATOM   3227 C CB   . THR A 1 212 ? 6.40000  37.29133  -0.79893  1.000 34.96960  ? 207 THR A CB   1 
ATOM   3228 O OG1  . THR A 1 212 ? 7.22039  36.24698  -0.24850  1.000 15.67743  ? 207 THR A OG1  1 
ATOM   3229 C CG2  . THR A 1 212 ? 5.87374  38.17267  0.32369   1.000 30.12819  ? 207 THR A CG2  1 
ATOM   3230 H H    . THR A 1 212 ? 4.71930  35.52836  -0.12592  1.000 26.36080  ? 207 THR A H    1 
ATOM   3231 H HA   . THR A 1 212 ? 4.76155  37.36468  -2.05941  1.000 34.54553  ? 207 THR A HA   1 
ATOM   3232 H HB   . THR A 1 212 ? 6.92723  37.86403  -1.37768  1.000 41.98593  ? 207 THR A HB   1 
ATOM   3233 H HG1  . THR A 1 212 ? 6.78792  35.81572  0.32819   1.000 18.83532  ? 207 THR A HG1  1 
ATOM   3234 H HG21 . THR A 1 212 ? 5.26614  38.83862  -0.03441  1.000 36.17623  ? 207 THR A HG21 1 
ATOM   3235 H HG22 . THR A 1 212 ? 5.40008  37.63240  0.97535   1.000 36.17623  ? 207 THR A HG22 1 
ATOM   3236 H HG23 . THR A 1 212 ? 6.61068  38.62364  0.76465   1.000 36.17623  ? 207 THR A HG23 1 
ATOM   3237 N N    . LEU A 1 213 ? 5.61052  34.50776  -2.76976  1.000 30.49490  ? 208 LEU A N    1 
ATOM   3238 C CA   . LEU A 1 213 ? 6.35026  33.51478  -3.53408  1.000 29.23474  ? 208 LEU A CA   1 
ATOM   3239 C C    . LEU A 1 213 ? 5.60637  33.01158  -4.76779  1.000 29.39477  ? 208 LEU A C    1 
ATOM   3240 O O    . LEU A 1 213 ? 4.37362  33.03235  -4.83745  1.000 34.79763  ? 208 LEU A O    1 
ATOM   3241 C CB   . LEU A 1 213 ? 6.67167  32.30498  -2.65279  1.000 24.83288  ? 208 LEU A CB   1 
ATOM   3242 C CG   . LEU A 1 213 ? 7.43893  32.63106  -1.36101  1.000 39.85444  ? 208 LEU A CG   1 
ATOM   3243 C CD1  . LEU A 1 213 ? 7.45030  31.44336  -0.41358  1.000 31.05947  ? 208 LEU A CD1  1 
ATOM   3244 C CD2  . LEU A 1 213 ? 8.88557  33.11218  -1.63335  1.000 23.43338  ? 208 LEU A CD2  1 
ATOM   3245 H H    . LEU A 1 213 ? 4.93019  34.17181  -2.36492  1.000 36.61628  ? 208 LEU A H    1 
ATOM   3246 H HA   . LEU A 1 213 ? 7.15864  33.94597  -3.85267  1.000 35.10409  ? 208 LEU A HA   1 
ATOM   3247 H HB2  . LEU A 1 213 ? 5.83736  31.88099  -2.39771  1.000 29.82186  ? 208 LEU A HB2  1 
ATOM   3248 H HB3  . LEU A 1 213 ? 7.21448  31.68673  -3.16662  1.000 29.82186  ? 208 LEU A HB3  1 
ATOM   3249 H HG   . LEU A 1 213 ? 6.97086  33.36432  -0.93191  1.000 47.84773  ? 208 LEU A HG   1 
ATOM   3250 H HD11 . LEU A 1 213 ? 7.82596  30.67626  -0.87329  1.000 37.29376  ? 208 LEU A HD11 1 
ATOM   3251 H HD12 . LEU A 1 213 ? 7.99150  31.66246  0.36102   1.000 37.29376  ? 208 LEU A HD12 1 
ATOM   3252 H HD13 . LEU A 1 213 ? 6.54053  31.25076  -0.13768  1.000 37.29376  ? 208 LEU A HD13 1 
ATOM   3253 H HD21 . LEU A 1 213 ? 9.37885  33.11826  -0.79816  1.000 28.14246  ? 208 LEU A HD21 1 
ATOM   3254 H HD22 . LEU A 1 213 ? 9.30705  32.50555  -2.26204  1.000 28.14246  ? 208 LEU A HD22 1 
ATOM   3255 H HD23 . LEU A 1 213 ? 8.85578  34.00707  -2.00644  1.000 28.14246  ? 208 LEU A HD23 1 
ATOM   3256 N N    . SER A 1 214 ? 6.39249  32.55359  -5.73726  1.000 34.75963  ? 209 SER A N    1 
ATOM   3257 C CA   . SER A 1 214 ? 5.89585  31.80237  -6.88017  1.000 42.68183  ? 209 SER A CA   1 
ATOM   3258 C C    . SER A 1 214 ? 5.44380  30.40394  -6.45621  1.000 23.22782  ? 209 SER A C    1 
ATOM   3259 O O    . SER A 1 214 ? 5.80705  29.90886  -5.38893  1.000 33.45532  ? 209 SER A O    1 
ATOM   3260 C CB   . SER A 1 214 ? 6.99168  31.66797  -7.94705  1.000 22.32534  ? 209 SER A CB   1 
ATOM   3261 O OG   . SER A 1 214 ? 8.08914  30.87167  -7.48474  1.000 25.81913  ? 209 SER A OG   1 
ATOM   3262 H H    . SER A 1 214 ? 7.24451  32.66894  -5.75607  1.000 41.73396  ? 209 SER A H    1 
ATOM   3263 H HA   . SER A 1 214 ? 5.13794  32.27705  -7.25587  1.000 51.24059  ? 209 SER A HA   1 
ATOM   3264 H HB2  . SER A 1 214 ? 6.61101  31.24768  -8.73404  1.000 26.81280  ? 209 SER A HB2  1 
ATOM   3265 H HB3  . SER A 1 214 ? 7.32043  32.55296  -8.16980  1.000 26.81280  ? 209 SER A HB3  1 
ATOM   3266 H HG   . SER A 1 214 ? 8.64098  30.75407  -8.10703  1.000 31.00536  ? 209 SER A HG   1 
ATOM   3267 N N    . GLU A 1 215 ? 4.70550  29.73671  -7.35377  1.000 32.34963  ? 210 GLU A N    1 
ATOM   3268 C CA   . GLU A 1 215 ? 4.28228  28.35488  -7.11249  1.000 49.72521  ? 210 GLU A CA   1 
ATOM   3269 C C    . GLU A 1 215 ? 5.46066  27.38557  -6.97471  1.000 28.42991  ? 210 GLU A C    1 
ATOM   3270 O O    . GLU A 1 215 ? 5.33166  26.35480  -6.30257  1.000 41.99013  ? 210 GLU A O    1 
ATOM   3271 C CB   . GLU A 1 215 ? 3.35239  27.87572  -8.23928  1.000 48.69822  ? 210 GLU A CB   1 
ATOM   3272 C CG   . GLU A 1 215 ? 2.94511  26.38033  -8.15024  1.000 72.32684  ? 210 GLU A CG   1 
ATOM   3273 C CD   . GLU A 1 215 ? 1.86689  26.05204  -7.10244  1.000 97.26554  ? 210 GLU A CD   1 
ATOM   3274 O OE1  . GLU A 1 215 ? 2.22278  25.63501  -5.97471  1.000 93.71473  ? 210 GLU A OE1  1 
ATOM   3275 O OE2  . GLU A 1 215 ? 0.66303  26.13598  -7.43522  1.000 84.62163  ? 210 GLU A OE2  1 
ATOM   3276 H H    . GLU A 1 215 ? 4.43889  30.06015  -8.10470  1.000 38.84196  ? 210 GLU A H    1 
ATOM   3277 H HA   . GLU A 1 215 ? 3.79212  28.34470  -6.27550  1.000 59.69266  ? 210 GLU A HA   1 
ATOM   3278 H HB2  . GLU A 1 215 ? 2.53839  28.40256  -8.21234  1.000 58.46027  ? 210 GLU A HB2  1 
ATOM   3279 H HB3  . GLU A 1 215 ? 3.80383  28.00577  -9.08792  1.000 58.46027  ? 210 GLU A HB3  1 
ATOM   3280 H HG2  . GLU A 1 215 ? 2.60134  26.10482  -9.01443  1.000 86.81461  ? 210 GLU A HG2  1 
ATOM   3281 H HG3  . GLU A 1 215 ? 3.73328  25.86133  -7.92593  1.000 86.81461  ? 210 GLU A HG3  1 
ATOM   3282 N N    . ASP A 1 216 ? 6.58903  27.65744  -7.62175  1.000 29.79881  ? 211 ASP A N    1 
ATOM   3283 C CA   . ASP A 1 216 ? 7.72683  26.75302  -7.49391  1.000 31.16354  ? 211 ASP A CA   1 
ATOM   3284 C C    . ASP A 1 216 ? 8.41324  26.94297  -6.14564  1.000 22.99369  ? 211 ASP A C    1 
ATOM   3285 O O    . ASP A 1 216 ? 8.91268  25.98130  -5.54599  1.000 26.24123  ? 211 ASP A O    1 
ATOM   3286 C CB   . ASP A 1 216 ? 8.73032  26.99547  -8.62407  1.000 44.33241  ? 211 ASP A CB   1 
ATOM   3287 C CG   . ASP A 1 216 ? 8.50115  26.09507  -9.81958  1.000 48.78277  ? 211 ASP A CG   1 
ATOM   3288 O OD1  . ASP A 1 216 ? 7.33428  25.66841  -10.04517 1.000 46.01601  ? 211 ASP A OD1  1 
ATOM   3289 O OD2  . ASP A 1 216 ? 9.49818  25.82711  -10.53340 1.000 64.87117  ? 211 ASP A OD2  1 
ATOM   3290 H H    . ASP A 1 216 ? 6.71924  28.34045  -8.12785  1.000 35.78097  ? 211 ASP A H    1 
ATOM   3291 H HA   . ASP A 1 216 ? 7.41214  25.83832  -7.56603  1.000 37.41865  ? 211 ASP A HA   1 
ATOM   3292 H HB2  . ASP A 1 216 ? 8.65282  27.91505  -8.92285  1.000 53.22129  ? 211 ASP A HB2  1 
ATOM   3293 H HB3  . ASP A 1 216 ? 9.62621  26.82907  -8.29153  1.000 53.22129  ? 211 ASP A HB3  1 
ATOM   3294 N N    . SER A 1 217 ? 8.45195  28.18256  -5.67339  1.000 25.92722  ? 212 SER A N    1 
ATOM   3295 C CA   . SER A 1 217 ? 9.11188  28.46684  -4.40617  1.000 21.05797  ? 212 SER A CA   1 
ATOM   3296 C C    . SER A 1 217 ? 8.23565  28.06269  -3.22069  1.000 28.39748  ? 212 SER A C    1 
ATOM   3297 O O    . SER A 1 217 ? 8.73399  27.44141  -2.26991  1.000 10.34972  ? 212 SER A O    1 
ATOM   3298 C CB   . SER A 1 217 ? 9.47587  29.94028  -4.35567  1.000 30.88053  ? 212 SER A CB   1 
ATOM   3299 O OG   . SER A 1 217 ? 10.60838 30.18396  -5.17476  1.000 21.09558  ? 212 SER A OG   1 
ATOM   3300 H H    . SER A 1 217 ? 8.10841  28.86873  -6.06166  1.000 31.13506  ? 212 SER A H    1 
ATOM   3301 H HA   . SER A 1 217 ? 9.93391  27.95642  -4.33815  1.000 25.29196  ? 212 SER A HA   1 
ATOM   3302 H HB2  . SER A 1 217 ? 8.72774  30.46590  -4.67959  1.000 37.07904  ? 212 SER A HB2  1 
ATOM   3303 H HB3  . SER A 1 217 ? 9.68353  30.18733  -3.44094  1.000 37.07904  ? 212 SER A HB3  1 
ATOM   3304 H HG   . SER A 1 217 ? 10.74813 31.01018  -5.23336  1.000 25.33710  ? 212 SER A HG   1 
ATOM   3305 N N    . TYR A 1 218 ? 6.93429  28.38796  -3.27163  1.000 19.82214  ? 213 TYR A N    1 
ATOM   3306 C CA   . TYR A 1 218 ? 5.95643  27.84560  -2.33189  1.000 32.59872  ? 213 TYR A CA   1 
ATOM   3307 C C    . TYR A 1 218 ? 6.16978  26.35818  -2.06959  1.000 39.78507  ? 213 TYR A C    1 
ATOM   3308 O O    . TYR A 1 218 ? 6.19326  25.92316  -0.91574  1.000 27.02759  ? 213 TYR A O    1 
ATOM   3309 C CB   . TYR A 1 218 ? 4.55235  28.09491  -2.89666  1.000 21.08897  ? 213 TYR A CB   1 
ATOM   3310 C CG   . TYR A 1 218 ? 3.37245  27.69399  -2.03171  1.000 18.73936  ? 213 TYR A CG   1 
ATOM   3311 C CD1  . TYR A 1 218 ? 2.84788  28.58376  -1.09279  1.000 27.30171  ? 213 TYR A CD1  1 
ATOM   3312 C CD2  . TYR A 1 218 ? 2.73467  26.43996  -2.19585  1.000 13.82235  ? 213 TYR A CD2  1 
ATOM   3313 C CE1  . TYR A 1 218 ? 1.72300  28.23047  -0.28336  1.000 14.88665  ? 213 TYR A CE1  1 
ATOM   3314 C CE2  . TYR A 1 218 ? 1.61101  26.08725  -1.41479  1.000 27.98599  ? 213 TYR A CE2  1 
ATOM   3315 C CZ   . TYR A 1 218 ? 1.12254  26.98776  -0.46232  1.000 18.16981  ? 213 TYR A CZ   1 
ATOM   3316 O OH   . TYR A 1 218 ? 0.02918  26.67304  0.31100   1.000 41.06545  ? 213 TYR A OH   1 
ATOM   3317 H H    . TYR A 1 218 ? 6.59357  28.92675  -3.84887  1.000 23.80897  ? 213 TYR A H    1 
ATOM   3318 H HA   . TYR A 1 218 ? 6.04747  28.30068  -1.48011  1.000 39.14087  ? 213 TYR A HA   1 
ATOM   3319 H HB2  . TYR A 1 218 ? 4.46461  29.04564  -3.06789  1.000 25.32917  ? 213 TYR A HB2  1 
ATOM   3320 H HB3  . TYR A 1 218 ? 4.47291  27.59957  -3.72685  1.000 25.32917  ? 213 TYR A HB3  1 
ATOM   3321 H HD1  . TYR A 1 218 ? 3.23726  29.42225  -0.99167  1.000 32.78446  ? 213 TYR A HD1  1 
ATOM   3322 H HD2  . TYR A 1 218 ? 3.06029  25.83968  -2.82714  1.000 16.60922  ? 213 TYR A HD2  1 
ATOM   3323 H HE1  . TYR A 1 218 ? 1.39692  28.82358  0.35444   1.000 17.88638  ? 213 TYR A HE1  1 
ATOM   3324 H HE2  . TYR A 1 218 ? 1.19904  25.26193  -1.53324  1.000 33.60559  ? 213 TYR A HE2  1 
ATOM   3325 H HH   . TYR A 1 218 ? -0.29045 25.93466  0.06968   1.000 49.30094  ? 213 TYR A HH   1 
ATOM   3326 N N    . LYS A 1 219 ? 6.33761  25.56562  -3.13401  1.000 24.18235  ? 214 LYS A N    1 
ATOM   3327 C CA   . LYS A 1 219 ? 6.44906  24.11414  -2.98912  1.000 24.06738  ? 214 LYS A CA   1 
ATOM   3328 C C    . LYS A 1 219 ? 7.74258  23.72176  -2.28181  1.000 18.09651  ? 214 LYS A C    1 
ATOM   3329 O O    . LYS A 1 219 ? 7.75986  22.78451  -1.47791  1.000 25.28203  ? 214 LYS A O    1 
ATOM   3330 C CB   . LYS A 1 219 ? 6.35726  23.48238  -4.38888  1.000 25.66950  ? 214 LYS A CB   1 
ATOM   3331 C CG   . LYS A 1 219 ? 6.14737  21.97765  -4.44653  1.000 43.76616  ? 214 LYS A CG   1 
ATOM   3332 C CD   . LYS A 1 219 ? 4.83972  21.63921  -5.20569  1.000 67.89338  ? 214 LYS A CD   1 
ATOM   3333 C CE   . LYS A 1 219 ? 4.33587  20.21068  -4.94793  1.000 59.33443  ? 214 LYS A CE   1 
ATOM   3334 N NZ   . LYS A 1 219 ? 5.36209  19.16085  -5.21489  1.000 81.30713  ? 214 LYS A NZ   1 
ATOM   3335 H H    . LYS A 1 219 ? 6.38973  25.84288  -3.94642  1.000 29.04122  ? 214 LYS A H    1 
ATOM   3336 H HA   . LYS A 1 219 ? 5.72113  23.77441  -2.44543  1.000 28.90325  ? 214 LYS A HA   1 
ATOM   3337 H HB2  . LYS A 1 219 ? 5.61069  23.89083  -4.85439  1.000 30.82580  ? 214 LYS A HB2  1 
ATOM   3338 H HB3  . LYS A 1 219 ? 7.18462  23.67144  -4.85860  1.000 30.82580  ? 214 LYS A HB3  1 
ATOM   3339 H HG2  . LYS A 1 219 ? 6.89075  21.56355  -4.91216  1.000 52.54179  ? 214 LYS A HG2  1 
ATOM   3340 H HG3  . LYS A 1 219 ? 6.08177  21.62404  -3.54567  1.000 52.54179  ? 214 LYS A HG3  1 
ATOM   3341 H HD2  . LYS A 1 219 ? 4.14477  22.25432  -4.92358  1.000 81.49446  ? 214 LYS A HD2  1 
ATOM   3342 H HD3  . LYS A 1 219 ? 4.99714  21.73086  -6.15843  1.000 81.49446  ? 214 LYS A HD3  1 
ATOM   3343 H HE2  . LYS A 1 219 ? 4.06926  20.13524  -4.01834  1.000 71.22372  ? 214 LYS A HE2  1 
ATOM   3344 H HE3  . LYS A 1 219 ? 3.57654  20.03699  -5.52599  1.000 71.22372  ? 214 LYS A HE3  1 
ATOM   3345 H HZ1  . LYS A 1 219 ? 5.57785  19.15867  -6.07834  1.000 97.59096  ? 214 LYS A HZ1  1 
ATOM   3346 H HZ2  . LYS A 1 219 ? 5.04247  18.35985  -4.99502  1.000 97.59096  ? 214 LYS A HZ2  1 
ATOM   3347 H HZ3  . LYS A 1 219 ? 6.09400  19.32154  -4.73469  1.000 97.59096  ? 214 LYS A HZ3  1 
ATOM   3348 N N    . ASP A 1 220 ? 8.83882  24.41544  -2.57466  1.000 10.35671  ? 215 ASP A N    1 
ATOM   3349 C CA   . ASP A 1 220 ? 10.09629 24.11513  -1.90527  1.000 16.70820  ? 215 ASP A CA   1 
ATOM   3350 C C    . ASP A 1 220 ? 10.02501 24.38902  -0.38959  1.000 26.62448  ? 215 ASP A C    1 
ATOM   3351 O O    . ASP A 1 220 ? 10.50515 23.58425  0.40908   1.000 15.28059  ? 215 ASP A O    1 
ATOM   3352 C CB   . ASP A 1 220 ? 11.22362 24.92873  -2.55123  1.000 30.90106  ? 215 ASP A CB   1 
ATOM   3353 C CG   . ASP A 1 220 ? 11.45721 24.57531  -4.04990  1.000 42.72445  ? 215 ASP A CG   1 
ATOM   3354 O OD1  . ASP A 1 220 ? 11.61500 23.37962  -4.38938  1.000 34.23542  ? 215 ASP A OD1  1 
ATOM   3355 O OD2  . ASP A 1 220 ? 11.50494 25.50071  -4.89453  1.000 40.02705  ? 215 ASP A OD2  1 
ATOM   3356 H H    . ASP A 1 220 ? 8.87997  25.05487  -3.14828  1.000 12.45045  ? 215 ASP A H    1 
ATOM   3357 H HA   . ASP A 1 220 ? 10.29093 23.17133  -2.01601  1.000 20.07224  ? 215 ASP A HA   1 
ATOM   3358 H HB2  . ASP A 1 220 ? 11.00043 25.87125  -2.49894  1.000 37.10368  ? 215 ASP A HB2  1 
ATOM   3359 H HB3  . ASP A 1 220 ? 12.04945 24.75629  -2.07250  1.000 37.10368  ? 215 ASP A HB3  1 
ATOM   3360 N N    . SER A 1 221 ? 9.41996  25.51325  0.03418   1.000 21.06864  ? 216 SER A N    1 
ATOM   3361 C CA   . SER A 1 221 ? 9.43128  25.84813  1.46859   1.000 23.37857  ? 216 SER A CA   1 
ATOM   3362 C C    . SER A 1 221 ? 8.43117  25.03533  2.28581   1.000 23.57953  ? 216 SER A C    1 
ATOM   3363 O O    . SER A 1 221 ? 8.66502  24.77316  3.47949   1.000 18.53187  ? 216 SER A O    1 
ATOM   3364 C CB   . SER A 1 221 ? 9.11213  27.32971  1.69197   1.000 28.86834  ? 216 SER A CB   1 
ATOM   3365 O OG   . SER A 1 221 ? 10.03723 28.18221  1.06480   1.000 16.24945  ? 216 SER A OG   1 
ATOM   3366 H H    . SER A 1 221 ? 9.01134  26.07743  -0.47013  1.000 25.30476  ? 216 SER A H    1 
ATOM   3367 H HA   . SER A 1 221 ? 10.32879 25.65930  1.78437   1.000 28.07669  ? 216 SER A HA   1 
ATOM   3368 H HB2  . SER A 1 221 ? 8.23018  27.51314  1.33222   1.000 34.66440  ? 216 SER A HB2  1 
ATOM   3369 H HB3  . SER A 1 221 ? 9.12519  27.50795  2.64536   1.000 34.66440  ? 216 SER A HB3  1 
ATOM   3370 H HG   . SER A 1 221 ? 9.75793  28.97415  1.08538   1.000 19.52174  ? 216 SER A HG   1 
ATOM   3371 N N    . THR A 1 222 ? 7.29089  24.67463  1.69201   1.000 15.53418  ? 217 THR A N    1 
ATOM   3372 C CA   . THR A 1 222 ? 6.28679  23.94392  2.46136   1.000 17.97592  ? 217 THR A CA   1 
ATOM   3373 C C    . THR A 1 222 ? 6.74839  22.53094  2.74010   1.000 21.32520  ? 217 THR A C    1 
ATOM   3374 O O    . THR A 1 222 ? 6.43686  21.97132  3.79993   1.000 29.18250  ? 217 THR A O    1 
ATOM   3375 C CB   . THR A 1 222 ? 4.92883  23.93261  1.76637   1.000 11.54893  ? 217 THR A CB   1 
ATOM   3376 O OG1  . THR A 1 222 ? 5.04394  23.54683  0.39982   1.000 23.57576  ? 217 THR A OG1  1 
ATOM   3377 C CG2  . THR A 1 222 ? 4.29642  25.32579  1.85884   1.000 26.52192  ? 217 THR A CG2  1 
ATOM   3378 H H    . THR A 1 222 ? 7.08238  24.83566  0.87336   1.000 18.66342  ? 217 THR A H    1 
ATOM   3379 H HA   . THR A 1 222 ? 6.15631  24.40927  3.30238   1.000 21.59351  ? 217 THR A HA   1 
ATOM   3380 H HB   . THR A 1 222 ? 4.35445  23.28554  2.20486   1.000 13.88112  ? 217 THR A HB   1 
ATOM   3381 H HG1  . THR A 1 222 ? 4.31918  23.68812  -0.00062  1.000 28.31331  ? 217 THR A HG1  1 
ATOM   3382 H HG21 . THR A 1 222 ? 4.30126  25.63190  2.77926   1.000 31.84871  ? 217 THR A HG21 1 
ATOM   3383 H HG22 . THR A 1 222 ? 4.79719  25.95418  1.31547   1.000 31.84871  ? 217 THR A HG22 1 
ATOM   3384 H HG23 . THR A 1 222 ? 3.38017  25.29591  1.54184   1.000 31.84871  ? 217 THR A HG23 1 
ATOM   3385 N N    . LEU A 1 223 ? 7.53200  21.96370  1.82902   1.000 25.27511  ? 218 LEU A N    1 
ATOM   3386 C CA   . LEU A 1 223 ? 8.28530  20.74056  2.09539   1.000 29.10501  ? 218 LEU A CA   1 
ATOM   3387 C C    . LEU A 1 223 ? 8.94558  20.75203  3.48419   1.000 34.17298  ? 218 LEU A C    1 
ATOM   3388 O O    . LEU A 1 223 ? 8.64722  19.90788  4.34315   1.000 24.94695  ? 218 LEU A O    1 
ATOM   3389 C CB   . LEU A 1 223 ? 9.31259  20.59760  0.95971   1.000 32.98162  ? 218 LEU A CB   1 
ATOM   3390 C CG   . LEU A 1 223 ? 9.96779  19.28242  0.53238   1.000 45.96212  ? 218 LEU A CG   1 
ATOM   3391 C CD1  . LEU A 1 223 ? 11.03675 18.85074  1.53979   1.000 50.11572  ? 218 LEU A CD1  1 
ATOM   3392 C CD2  . LEU A 1 223 ? 8.96552  18.18799  0.31854   1.000 40.45380  ? 218 LEU A CD2  1 
ATOM   3393 H H    . LEU A 1 223 ? 7.64781  22.27152  1.03439   1.000 30.35253  ? 218 LEU A H    1 
ATOM   3394 H HA   . LEU A 1 223 ? 7.69927  19.96761  2.09798   1.000 34.94841  ? 218 LEU A HA   1 
ATOM   3395 H HB2  . LEU A 1 223 ? 8.87373  20.92714  0.15990   1.000 39.60034  ? 218 LEU A HB2  1 
ATOM   3396 H HB3  . LEU A 1 223 ? 10.05305 21.17832  1.19504   1.000 39.60034  ? 218 LEU A HB3  1 
ATOM   3397 H HG   . LEU A 1 223 ? 10.39954 19.43642  -0.32247  1.000 55.17694  ? 218 LEU A HG   1 
ATOM   3398 H HD11 . LEU A 1 223 ? 11.42773 18.01309  1.24591   1.000 60.16127  ? 218 LEU A HD11 1 
ATOM   3399 H HD12 . LEU A 1 223 ? 11.72111 19.53652  1.58740   1.000 60.16127  ? 218 LEU A HD12 1 
ATOM   3400 H HD13 . LEU A 1 223 ? 10.62290 18.73550  2.40947   1.000 60.16127  ? 218 LEU A HD13 1 
ATOM   3401 H HD21 . LEU A 1 223 ? 9.43317  17.37618  0.06721   1.000 48.56696  ? 218 LEU A HD21 1 
ATOM   3402 H HD22 . LEU A 1 223 ? 8.47365  18.04486  1.14224   1.000 48.56696  ? 218 LEU A HD22 1 
ATOM   3403 H HD23 . LEU A 1 223 ? 8.35643  18.45139  -0.38894  1.000 48.56696  ? 218 LEU A HD23 1 
ATOM   3404 N N    . ILE A 1 224 ? 9.81948  21.73006  3.73963   1.000 32.13708  ? 219 ILE A N    1 
ATOM   3405 C CA   . ILE A 1 224 ? 10.62462 21.73001  4.96448   1.000 13.37621  ? 219 ILE A CA   1 
ATOM   3406 C C    . ILE A 1 224 ? 9.82204  22.18030  6.19564   1.000 14.20479  ? 219 ILE A C    1 
ATOM   3407 O O    . ILE A 1 224 ? 10.14138 21.77786  7.31386   1.000 15.95239  ? 219 ILE A O    1 
ATOM   3408 C CB   . ILE A 1 224 ? 11.86825 22.62728  4.81072   1.000 24.43434  ? 219 ILE A CB   1 
ATOM   3409 C CG1  . ILE A 1 224 ? 12.62904 22.30497  3.53460   1.000 15.41151  ? 219 ILE A CG1  1 
ATOM   3410 C CG2  . ILE A 1 224 ? 12.81290 22.48971  6.01471   1.000 21.97568  ? 219 ILE A CG2  1 
ATOM   3411 C CD1  . ILE A 1 224 ? 13.77764 23.19522  3.30262   1.000 27.99145  ? 219 ILE A CD1  1 
ATOM   3412 H H    . ILE A 1 224 ? 9.96526  22.40220  3.22332   1.000 38.58690  ? 219 ILE A H    1 
ATOM   3413 H HA   . ILE A 1 224 ? 10.90547 20.81171  5.10139   1.000 16.07386  ? 219 ILE A HA   1 
ATOM   3414 H HB   . ILE A 1 224 ? 11.54618 23.54108  4.76449   1.000 29.34361  ? 219 ILE A HB   1 
ATOM   3415 H HG12 . ILE A 1 224 ? 12.96265 21.39579  3.58921   1.000 18.51622  ? 219 ILE A HG12 1 
ATOM   3416 H HG13 . ILE A 1 224 ? 12.02658 22.39250  2.77942   1.000 18.51622  ? 219 ILE A HG13 1 
ATOM   3417 H HG21 . ILE A 1 224 ? 13.51301 23.15743  5.94473   1.000 26.39322  ? 219 ILE A HG21 1 
ATOM   3418 H HG22 . ILE A 1 224 ? 12.30639 22.62580  6.83069   1.000 26.39322  ? 219 ILE A HG22 1 
ATOM   3419 H HG23 . ILE A 1 224 ? 13.20177 21.60107  6.01109   1.000 26.39322  ? 219 ILE A HG23 1 
ATOM   3420 H HD11 . ILE A 1 224 ? 13.49578 24.11442  3.43124   1.000 33.61214  ? 219 ILE A HD11 1 
ATOM   3421 H HD12 . ILE A 1 224 ? 14.48116 22.97373  3.93263   1.000 33.61214  ? 219 ILE A HD12 1 
ATOM   3422 H HD13 . ILE A 1 224 ? 14.09543 23.07065  2.39466   1.000 33.61214  ? 219 ILE A HD13 1 
ATOM   3423 N N    . MET A 1 225 ? 8.80947  23.02516  6.02307   1.000 18.68518  ? 220 MET A N    1 
ATOM   3424 C CA   . MET A 1 225 ? 7.95259  23.41714  7.13534   1.000 22.05685  ? 220 MET A CA   1 
ATOM   3425 C C    . MET A 1 225 ? 7.14467  22.23444  7.67143   1.000 22.76972  ? 220 MET A C    1 
ATOM   3426 O O    . MET A 1 225 ? 6.76641  22.23139  8.84930   1.000 14.86702  ? 220 MET A O    1 
ATOM   3427 C CB   . MET A 1 225 ? 6.99229  24.54448  6.69479   1.000 18.77121  ? 220 MET A CB   1 
ATOM   3428 C CG   . MET A 1 225 ? 7.60840  25.91226  6.45564   1.000 22.69491  ? 220 MET A CG   1 
ATOM   3429 S SD   . MET A 1 225 ? 6.51412  26.98522  5.39937   1.000 27.75692  ? 220 MET A SD   1 
ATOM   3430 C CE   . MET A 1 225 ? 5.10895  27.21916  6.52431   1.000 14.99457  ? 220 MET A CE   1 
ATOM   3431 H H    . MET A 1 225 ? 8.59698  23.38599  5.27190   1.000 22.44461  ? 220 MET A H    1 
ATOM   3432 H HA   . MET A 1 225 ? 8.51802  23.76071  7.84466   1.000 26.49062  ? 220 MET A HA   1 
ATOM   3433 H HB2  . MET A 1 225 ? 6.57259  24.27347  5.86334   1.000 22.54785  ? 220 MET A HB2  1 
ATOM   3434 H HB3  . MET A 1 225 ? 6.32015  24.65334  7.38564   1.000 22.54785  ? 220 MET A HB3  1 
ATOM   3435 H HG2  . MET A 1 225 ? 7.74030  26.35726  7.30740   1.000 27.25629  ? 220 MET A HG2  1 
ATOM   3436 H HG3  . MET A 1 225 ? 8.45909  25.80525  6.00201   1.000 27.25629  ? 220 MET A HG3  1 
ATOM   3437 H HE1  . MET A 1 225 ? 4.45973  27.80283  6.10154   1.000 18.01588  ? 220 MET A HE1  1 
ATOM   3438 H HE2  . MET A 1 225 ? 4.70640  26.35649  6.71044   1.000 18.01588  ? 220 MET A HE2  1 
ATOM   3439 H HE3  . MET A 1 225 ? 5.42731  27.62028  7.34812   1.000 18.01588  ? 220 MET A HE3  1 
ATOM   3440 N N    A GLN A 1 226 ? 6.84841  21.23803  6.82200   0.957 20.58361  ? 221 GLN A N    1 
ATOM   3441 N N    B GLN A 1 226 ? 6.85607  21.24425  6.82267   0.043 20.76200  ? 221 GLN A N    1 
ATOM   3442 C CA   A GLN A 1 226 ? 6.12481  20.05194  7.27599   0.957 27.38340  ? 221 GLN A CA   1 
ATOM   3443 C CA   B GLN A 1 226 ? 6.12884  20.06627  7.28173   0.043 27.20496  ? 221 GLN A CA   1 
ATOM   3444 C C    A GLN A 1 226 ? 6.96198  19.19032  8.21288   0.957 24.71033  ? 221 GLN A C    1 
ATOM   3445 C C    B GLN A 1 226 ? 6.96333  19.26292  8.26806   0.043 24.81297  ? 221 GLN A C    1 
ATOM   3446 O O    A GLN A 1 226 ? 6.41229  18.47759  9.05584   0.957 22.48550  ? 221 GLN A O    1 
ATOM   3447 O O    B GLN A 1 226 ? 6.42692  18.68132  9.21794   0.043 23.91950  ? 221 GLN A O    1 
ATOM   3448 C CB   A GLN A 1 226 ? 5.68207  19.18687  6.09288   0.957 35.00538  ? 221 GLN A CB   1 
ATOM   3449 C CB   B GLN A 1 226 ? 5.72898  19.19665  6.08914   0.043 34.39808  ? 221 GLN A CB   1 
ATOM   3450 C CG   A GLN A 1 226 ? 5.14770  17.80168  6.51043   0.957 37.75445  ? 221 GLN A CG   1 
ATOM   3451 C CG   B GLN A 1 226 ? 5.07535  17.87195  6.46744   0.043 37.19899  ? 221 GLN A CG   1 
ATOM   3452 C CD   A GLN A 1 226 ? 3.83434  17.89036  7.27527   0.957 39.34872  ? 221 GLN A CD   1 
ATOM   3453 C CD   B GLN A 1 226 ? 3.75017  18.05815  7.17981   0.043 37.92177  ? 221 GLN A CD   1 
ATOM   3454 O OE1  A GLN A 1 226 ? 2.88558  18.52718  6.81742   0.957 36.17594  ? 221 GLN A OE1  1 
ATOM   3455 O OE1  B GLN A 1 226 ? 2.85375  18.73588  6.67802   0.043 35.56783  ? 221 GLN A OE1  1 
ATOM   3456 N NE2  A GLN A 1 226 ? 3.77485  17.24596  8.45075   0.957 40.19666  ? 221 GLN A NE2  1 
ATOM   3457 N NE2  B GLN A 1 226 ? 3.62036  17.45689  8.35817   0.043 38.01462  ? 221 GLN A NE2  1 
ATOM   3458 H H    A GLN A 1 226 ? 7.05481  21.22836  5.98719   0.957 24.72273  ? 221 GLN A H    1 
ATOM   3459 H H    B GLN A 1 226 ? 7.06778  21.23238  5.98922   0.043 24.93680  ? 221 GLN A H    1 
ATOM   3460 H HA   A GLN A 1 226 ? 5.33664  20.36563  7.74639   0.957 32.88248  ? 221 GLN A HA   1 
ATOM   3461 H HA   B GLN A 1 226 ? 5.31718  20.35259  7.72910   0.043 32.66835  ? 221 GLN A HA   1 
ATOM   3462 H HB2  A GLN A 1 226 ? 4.97383  19.64746  5.61627   0.957 42.02886  ? 221 GLN A HB2  1 
ATOM   3463 H HB2  B GLN A 1 226 ? 5.09683  19.69077  5.54404   0.043 41.30010  ? 221 GLN A HB2  1 
ATOM   3464 H HB3  A GLN A 1 226 ? 6.44137  19.04792  5.50547   0.957 42.02886  ? 221 GLN A HB3  1 
ATOM   3465 H HB3  B GLN A 1 226 ? 6.52498  18.99437  5.57302   0.043 41.30010  ? 221 GLN A HB3  1 
ATOM   3466 H HG2  A GLN A 1 226 ? 4.99749  17.26686  5.71526   0.957 45.32774  ? 221 GLN A HG2  1 
ATOM   3467 H HG2  B GLN A 1 226 ? 4.91352  17.35714  5.66141   0.043 44.66119  ? 221 GLN A HG2  1 
ATOM   3468 H HG3  A GLN A 1 226 ? 5.80071  17.36919  7.08266   0.957 45.32774  ? 221 GLN A HG3  1 
ATOM   3469 H HG3  B GLN A 1 226 ? 5.66876  17.38372  7.05939   0.043 44.66119  ? 221 GLN A HG3  1 
ATOM   3470 H HE21 A GLN A 1 226 ? 4.45875  16.81045  8.73747   0.957 48.25839  ? 221 GLN A HE21 1 
ATOM   3471 H HE21 B GLN A 1 226 ? 2.88711  17.53267  8.80112   0.043 45.63994  ? 221 GLN A HE21 1 
ATOM   3472 H HE22 A GLN A 1 226 ? 3.05281  17.26847  8.91740   0.957 48.25839  ? 221 GLN A HE22 1 
ATOM   3473 H HE22 B GLN A 1 226 ? 4.26962  16.99212  8.67760   0.043 45.63994  ? 221 GLN A HE22 1 
ATOM   3474 N N    . LEU A 1 227 ? 8.27793  19.21681  8.05847   1.000 22.03946  ? 222 LEU A N    1 
ATOM   3475 C CA   . LEU A 1 227 ? 9.13457  18.48510  8.97591   1.000 27.88715  ? 222 LEU A CA   1 
ATOM   3476 C C    . LEU A 1 227 ? 9.17965  19.16400  10.34203  1.000 27.68281  ? 222 LEU A C    1 
ATOM   3477 O O    . LEU A 1 227 ? 9.28233  18.47172  11.36743  1.000 21.18808  ? 222 LEU A O    1 
ATOM   3478 C CB   . LEU A 1 227 ? 10.53439 18.33437  8.36945   1.000 20.29546  ? 222 LEU A CB   1 
ATOM   3479 C CG   . LEU A 1 227 ? 10.61695 17.57220  7.03405   1.000 24.76840  ? 222 LEU A CG   1 
ATOM   3480 C CD1  . LEU A 1 227 ? 11.88985 17.86217  6.28092   1.000 20.32348  ? 222 LEU A CD1  1 
ATOM   3481 C CD2  . LEU A 1 227 ? 10.53948 16.08853  7.27287   1.000 21.03032  ? 222 LEU A CD2  1 
ATOM   3482 H H    A LEU A 1 227 ? 8.69431  19.64467  7.43947   0.957 26.46975  ? 222 LEU A H    1 
ATOM   3483 H H    B LEU A 1 227 ? 8.68810  19.59469  7.40382   0.043 26.46975  ? 222 LEU A H    1 
ATOM   3484 H HA   . LEU A 1 227 ? 8.78618  17.58984  9.11017   1.000 33.48699  ? 222 LEU A HA   1 
ATOM   3485 H HB2  . LEU A 1 227 ? 10.89376 19.22208  8.21542   1.000 24.37695  ? 222 LEU A HB2  1 
ATOM   3486 H HB3  . LEU A 1 227 ? 11.08946 17.85764  9.00626   1.000 24.37695  ? 222 LEU A HB3  1 
ATOM   3487 H HG   . LEU A 1 227 ? 9.86907  17.86933  6.49247   1.000 29.74448  ? 222 LEU A HG   1 
ATOM   3488 H HD11 . LEU A 1 227 ? 12.04928 18.81896  6.28678   1.000 24.41058  ? 222 LEU A HD11 1 
ATOM   3489 H HD12 . LEU A 1 227 ? 12.62524 17.40163  6.71452   1.000 24.41058  ? 222 LEU A HD12 1 
ATOM   3490 H HD13 . LEU A 1 227 ? 11.79518 17.54820  5.36803   1.000 24.41058  ? 222 LEU A HD13 1 
ATOM   3491 H HD21 . LEU A 1 227 ? 10.66430 15.62596  6.42945   1.000 25.25878  ? 222 LEU A HD21 1 
ATOM   3492 H HD22 . LEU A 1 227 ? 11.23644 15.83230  7.89696   1.000 25.25878  ? 222 LEU A HD22 1 
ATOM   3493 H HD23 . LEU A 1 227 ? 9.66893  15.87319  7.64255   1.000 25.25878  ? 222 LEU A HD23 1 
ATOM   3494 N N    . LEU A 1 228 ? 9.07371  20.50334  10.38416  1.000 19.22067  ? 223 LEU A N    1 
ATOM   3495 C CA   . LEU A 1 228 ? 9.00440  21.18655  11.67641  1.000 16.14315  ? 223 LEU A CA   1 
ATOM   3496 C C    . LEU A 1 228 ? 7.73220  20.80353  12.42004  1.000 14.76442  ? 223 LEU A C    1 
ATOM   3497 O O    . LEU A 1 228 ? 7.73918  20.64261  13.65087  1.000 12.68104  ? 223 LEU A O    1 
ATOM   3498 C CB   . LEU A 1 228 ? 9.05056  22.71019  11.50682  1.000 13.39028  ? 223 LEU A CB   1 
ATOM   3499 C CG   . LEU A 1 228 ? 10.23439 23.39136  10.86032  1.000 15.54832  ? 223 LEU A CG   1 
ATOM   3500 C CD1  . LEU A 1 228 ? 9.73223  24.76001  10.49667  1.000 18.87218  ? 223 LEU A CD1  1 
ATOM   3501 C CD2  . LEU A 1 228 ? 11.42410 23.48071  11.81160  1.000 8.03803   ? 223 LEU A CD2  1 
ATOM   3502 H H    . LEU A 1 228 ? 9.04128  21.02003  9.69744   1.000 23.08720  ? 223 LEU A H    1 
ATOM   3503 H HA   . LEU A 1 228 ? 9.78038  20.92073  12.19418  1.000 19.39418  ? 223 LEU A HA   1 
ATOM   3504 H HB2  . LEU A 1 228 ? 8.27940  22.95756  10.97295  1.000 16.09074  ? 223 LEU A HB2  1 
ATOM   3505 H HB3  . LEU A 1 228 ? 8.97676  23.09463  12.39432  1.000 16.09074  ? 223 LEU A HB3  1 
ATOM   3506 H HG   . LEU A 1 228 ? 10.56250 22.90377  10.08863  1.000 18.68039  ? 223 LEU A HG   1 
ATOM   3507 H HD11 . LEU A 1 228 ? 10.49055 25.35218  10.37343  1.000 22.66901  ? 223 LEU A HD11 1 
ATOM   3508 H HD12 . LEU A 1 228 ? 9.22166  24.70080  9.67405   1.000 22.66901  ? 223 LEU A HD12 1 
ATOM   3509 H HD13 . LEU A 1 228 ? 9.16787  25.09003  11.21325  1.000 22.66901  ? 223 LEU A HD13 1 
ATOM   3510 H HD21 . LEU A 1 228 ? 11.56562 22.61356  12.22260  1.000 9.66804   ? 223 LEU A HD21 1 
ATOM   3511 H HD22 . LEU A 1 228 ? 12.21170 23.74090  11.30871  1.000 9.66804   ? 223 LEU A HD22 1 
ATOM   3512 H HD23 . LEU A 1 228 ? 11.23366 24.14314  12.49411  1.000 9.66804   ? 223 LEU A HD23 1 
ATOM   3513 N N    . ARG A 1 229 ? 6.62798  20.68061  11.68467  1.000 13.60476  ? 224 ARG A N    1 
ATOM   3514 C CA   . ARG A 1 229 ? 5.36727  20.28564  12.30214  1.000 31.97355  ? 224 ARG A CA   1 
ATOM   3515 C C    . ARG A 1 229 ? 5.38618  18.83900  12.81336  1.000 24.52173  ? 224 ARG A C    1 
ATOM   3516 O O    . ARG A 1 229 ? 4.83797  18.55328  13.89014  1.000 20.61912  ? 224 ARG A O    1 
ATOM   3517 C CB   . ARG A 1 229 ? 4.21252  20.46809  11.31101  1.000 29.65744  ? 224 ARG A CB   1 
ATOM   3518 C CG   . ARG A 1 229 ? 2.85605  20.04122  11.88013  1.000 47.51164  ? 224 ARG A CG   1 
ATOM   3519 C CD   . ARG A 1 229 ? 1.69676  21.01520  11.55952  1.000 72.84530  ? 224 ARG A CD   1 
ATOM   3520 N NE   . ARG A 1 229 ? 1.76928  22.30348  12.25576  1.000 41.19391  ? 224 ARG A NE   1 
ATOM   3521 C CZ   . ARG A 1 229 ? 1.77816  22.48652  13.57647  1.000 62.49517  ? 224 ARG A CZ   1 
ATOM   3522 N NH1  . ARG A 1 229 ? 1.71778  21.46954  14.42285  1.000 71.74728  ? 224 ARG A NH1  1 
ATOM   3523 N NH2  . ARG A 1 229 ? 1.86044  23.72690  14.06276  1.000 48.68049  ? 224 ARG A NH2  1 
ATOM   3524 H H    . ARG A 1 229 ? 6.58320  20.81855  10.83699  1.000 16.34812  ? 224 ARG A H    1 
ATOM   3525 H HA   . ARG A 1 229 ? 5.22433  20.86634  13.06585  1.000 38.39066  ? 224 ARG A HA   1 
ATOM   3526 H HB2  . ARG A 1 229 ? 4.15266  21.40518  11.06771  1.000 35.61133  ? 224 ARG A HB2  1 
ATOM   3527 H HB3  . ARG A 1 229 ? 4.38777  19.93113  10.52244  1.000 35.61133  ? 224 ARG A HB3  1 
ATOM   3528 H HG2  . ARG A 1 229 ? 2.62238  19.17557  11.51006  1.000 57.03637  ? 224 ARG A HG2  1 
ATOM   3529 H HG3  . ARG A 1 229 ? 2.92934  19.98051  12.84545  1.000 57.03637  ? 224 ARG A HG3  1 
ATOM   3530 H HD2  . ARG A 1 229 ? 1.70142  21.19799  10.60690  1.000 87.43676  ? 224 ARG A HD2  1 
ATOM   3531 H HD3  . ARG A 1 229 ? 0.86045  20.59383  11.81238  1.000 87.43676  ? 224 ARG A HD3  1 
ATOM   3532 H HE   . ARG A 1 229 ? 1.80999  23.00872  11.76526  1.000 49.45509  ? 224 ARG A HE   1 
ATOM   3533 H HH11 . ARG A 1 229 ? 1.67128  20.66420  14.12475  1.000 86.11914  ? 224 ARG A HH11 1 
ATOM   3534 H HH12 . ARG A 1 229 ? 1.72509  21.61455  15.27050  1.000 86.11914  ? 224 ARG A HH12 1 
ATOM   3535 H HH21 . ARG A 1 229 ? 1.90699  24.39706  13.52581  1.000 58.43898  ? 224 ARG A HH21 1 
ATOM   3536 H HH22 . ARG A 1 229 ? 1.86691  23.85588  14.91300  1.000 58.43898  ? 224 ARG A HH22 1 
ATOM   3537 N N    . ASP A 1 230 ? 5.94985  17.90377  12.04448  1.000 15.02013  ? 225 ASP A N    1 
ATOM   3538 C CA   . ASP A 1 230 ? 6.01446  16.51470  12.51160  1.000 13.09063  ? 225 ASP A CA   1 
ATOM   3539 C C    . ASP A 1 230 ? 6.74061  16.39086  13.85732  1.000 19.87536  ? 225 ASP A C    1 
ATOM   3540 O O    . ASP A 1 230 ? 6.33909  15.59274  14.72319  1.000 11.81090  ? 225 ASP A O    1 
ATOM   3541 C CB   . ASP A 1 230 ? 6.72225  15.62981  11.47752  1.000 12.78362  ? 225 ASP A CB   1 
ATOM   3542 C CG   . ASP A 1 230 ? 5.95686  15.52443  10.14762  1.000 27.44282  ? 225 ASP A CG   1 
ATOM   3543 O OD1  . ASP A 1 230 ? 4.74700  15.86666  10.12542  1.000 18.28451  ? 225 ASP A OD1  1 
ATOM   3544 O OD2  . ASP A 1 230 ? 6.58364  15.11003  9.11582   1.000 20.00740  ? 225 ASP A OD2  1 
ATOM   3545 H H    . ASP A 1 230 ? 6.29375  18.04180  11.26841  1.000 18.04655  ? 225 ASP A H    1 
ATOM   3546 H HA   . ASP A 1 230 ? 5.10184  16.20503  12.62178  1.000 15.73116  ? 225 ASP A HA   1 
ATOM   3547 H HB2  . ASP A 1 230 ? 7.59719  16.00398  11.28939  1.000 15.36274  ? 225 ASP A HB2  1 
ATOM   3548 H HB3  . ASP A 1 230 ? 6.81511  14.73491  11.84006  1.000 15.36274  ? 225 ASP A HB3  1 
ATOM   3549 N N    . ASN A 1 231 ? 7.84498  17.13524  14.03438  1.000 17.78010  ? 226 ASN A N    1 
ATOM   3550 C CA   . ASN A 1 231 ? 8.61492  17.04098  15.27716  1.000 10.44675  ? 226 ASN A CA   1 
ATOM   3551 C C    . ASN A 1 231 ? 7.81559  17.59610  16.45368  1.000 16.14334  ? 226 ASN A C    1 
ATOM   3552 O O    . ASN A 1 231 ? 7.84083  17.03545  17.55308  1.000 24.78081  ? 226 ASN A O    1 
ATOM   3553 C CB   . ASN A 1 231 ? 9.97380  17.77256  15.13069  1.000 12.95775  ? 226 ASN A CB   1 
ATOM   3554 C CG   . ASN A 1 231 ? 10.94482 17.08182  14.12890  1.000 28.75192  ? 226 ASN A CG   1 
ATOM   3555 O OD1  . ASN A 1 231 ? 10.71322 15.93779  13.74109  1.000 36.67902  ? 226 ASN A OD1  1 
ATOM   3556 N ND2  . ASN A 1 231 ? 12.03053 17.78378  13.71471  1.000 21.72835  ? 226 ASN A ND2  1 
ATOM   3557 H H    . ASN A 1 231 ? 8.16116  17.69113  13.45939  1.000 21.35853  ? 226 ASN A H    1 
ATOM   3558 H HA   . ASN A 1 231 ? 8.80968  16.10805  15.45776  1.000 12.55850  ? 226 ASN A HA   1 
ATOM   3559 H HB2  . ASN A 1 231 ? 9.81146  18.67452  14.81286  1.000 15.57170  ? 226 ASN A HB2  1 
ATOM   3560 H HB3  . ASN A 1 231 ? 10.41018 17.79944  15.99657  1.000 15.57170  ? 226 ASN A HB3  1 
ATOM   3561 H HD21 . ASN A 1 231 ? 12.58590 17.43002  13.16152  1.000 26.09642  ? 226 ASN A HD21 1 
ATOM   3562 H HD22 . ASN A 1 231 ? 12.16292 18.58222  14.00552  1.000 26.09642  ? 226 ASN A HD22 1 
ATOM   3563 N N    . LEU A 1 232 ? 7.11259  18.70767  16.25697  1.000 21.85333  ? 227 LEU A N    1 
ATOM   3564 C CA   . LEU A 1 232 ? 6.36683  19.27836  17.37163  1.000 28.00604  ? 227 LEU A CA   1 
ATOM   3565 C C    . LEU A 1 232 ? 5.27350  18.32377  17.81732  1.000 36.42772  ? 227 LEU A C    1 
ATOM   3566 O O    . LEU A 1 232 ? 4.97474  18.21164  19.01876  1.000 21.68884  ? 227 LEU A O    1 
ATOM   3567 C CB   . LEU A 1 232 ? 5.76825  20.63087  16.97192  1.000 20.31488  ? 227 LEU A CB   1 
ATOM   3568 C CG   . LEU A 1 232 ? 6.79792  21.78685  16.89905  1.000 15.20384  ? 227 LEU A CG   1 
ATOM   3569 C CD1  . LEU A 1 232 ? 6.35229  22.93258  15.95050  1.000 13.04976  ? 227 LEU A CD1  1 
ATOM   3570 C CD2  . LEU A 1 232 ? 7.15436  22.32638  18.30128  1.000 9.77981   ? 227 LEU A CD2  1 
ATOM   3571 H H    . LEU A 1 232 ? 7.05286  19.13620  15.51373  1.000 26.24640  ? 227 LEU A H    1 
ATOM   3572 H HA   . LEU A 1 232 ? 6.96999  19.43204  18.11559  1.000 33.62965  ? 227 LEU A HA   1 
ATOM   3573 H HB2  . LEU A 1 232 ? 5.36225  20.54234  16.09544  1.000 24.40025  ? 227 LEU A HB2  1 
ATOM   3574 H HB3  . LEU A 1 232 ? 5.09536  20.87655  17.62596  1.000 24.40025  ? 227 LEU A HB3  1 
ATOM   3575 H HG   . LEU A 1 232 ? 7.60760  21.41527  16.51532  1.000 18.26701  ? 227 LEU A HG   1 
ATOM   3576 H HD11 . LEU A 1 232 ? 6.16857  22.56253  15.07288  1.000 15.68212  ? 227 LEU A HD11 1 
ATOM   3577 H HD12 . LEU A 1 232 ? 5.55162  23.34620  16.30930  1.000 15.68212  ? 227 LEU A HD12 1 
ATOM   3578 H HD13 . LEU A 1 232 ? 7.06478  23.58807  15.89056  1.000 15.68212  ? 227 LEU A HD13 1 
ATOM   3579 H HD21 . LEU A 1 232 ? 7.49425  21.59720  18.84321  1.000 11.75817  ? 227 LEU A HD21 1 
ATOM   3580 H HD22 . LEU A 1 232 ? 7.83118  23.01544  18.21187  1.000 11.75817  ? 227 LEU A HD22 1 
ATOM   3581 H HD23 . LEU A 1 232 ? 6.35633  22.69751  18.70910  1.000 11.75817  ? 227 LEU A HD23 1 
ATOM   3582 N N    . THR A 1 233 ? 4.65773  17.63430  16.85144  1.000 31.54286  ? 228 THR A N    1 
ATOM   3583 C CA   . THR A 1 233 ? 3.63368  16.64709  17.15571  1.000 30.60927  ? 228 THR A CA   1 
ATOM   3584 C C    . THR A 1 233 ? 4.21146  15.46551  17.91454  1.000 48.40762  ? 228 THR A C    1 
ATOM   3585 O O    . THR A 1 233 ? 3.49600  14.79755  18.67550  1.000 33.71151  ? 228 THR A O    1 
ATOM   3586 C CB   . THR A 1 233 ? 3.00648  16.12762  15.87170  1.000 16.76722  ? 228 THR A CB   1 
ATOM   3587 O OG1  . THR A 1 233 ? 2.69770  17.22217  14.99795  1.000 32.83070  ? 228 THR A OG1  1 
ATOM   3588 C CG2  . THR A 1 233 ? 1.77561  15.32930  16.21722  1.000 26.23764  ? 228 THR A CG2  1 
ATOM   3589 H H    . THR A 1 233 ? 4.81839  17.72305  16.01125  1.000 37.87383  ? 228 THR A H    1 
ATOM   3590 H HA   . THR A 1 233 ? 2.95108  17.07720  17.69419  1.000 36.75353  ? 228 THR A HA   1 
ATOM   3591 H HB   . THR A 1 233 ? 3.61922  15.54627  15.39475  1.000 20.14307  ? 228 THR A HB   1 
ATOM   3592 H HG1  . THR A 1 233 ? 3.40655  17.58321  14.72816  1.000 39.41924  ? 228 THR A HG1  1 
ATOM   3593 H HG21 . THR A 1 233 ? 2.00627  14.61139  16.82739  1.000 31.50757  ? 228 THR A HG21 1 
ATOM   3594 H HG22 . THR A 1 233 ? 1.11653  15.90200  16.63974  1.000 31.50757  ? 228 THR A HG22 1 
ATOM   3595 H HG23 . THR A 1 233 ? 1.39125  14.94735  15.41268  1.000 31.50757  ? 228 THR A HG23 1 
ATOM   3596 N N    . LEU A 1 234 ? 5.49392  15.18102  17.67002  1.000 40.87922  ? 229 LEU A N    1 
ATOM   3597 C CA   . LEU A 1 234 ? 6.19418  14.12423  18.37842  1.000 28.60815  ? 229 LEU A CA   1 
ATOM   3598 C C    . LEU A 1 234 ? 6.73566  14.60769  19.72156  1.000 29.86238  ? 229 LEU A C    1 
ATOM   3599 O O    . LEU A 1 234 ? 6.74359  13.84604  20.68473  1.000 29.79244  ? 229 LEU A O    1 
ATOM   3600 C CB   . LEU A 1 234 ? 7.32301  13.58819  17.49933  1.000 15.71738  ? 229 LEU A CB   1 
ATOM   3601 C CG   . LEU A 1 234 ? 8.28524  12.58201  18.13441  1.000 29.74423  ? 229 LEU A CG   1 
ATOM   3602 C CD1  . LEU A 1 234 ? 7.63773  11.22030  18.07913  1.000 25.19372  ? 229 LEU A CD1  1 
ATOM   3603 C CD2  . LEU A 1 234 ? 9.66605  12.53209  17.46310  1.000 38.42506  ? 229 LEU A CD2  1 
ATOM   3604 H H    . LEU A 1 234 ? 5.98046  15.59232  17.09234  1.000 49.07747  ? 229 LEU A H    1 
ATOM   3605 H HA   . LEU A 1 234 ? 5.57814  13.39721  18.55964  1.000 34.35218  ? 229 LEU A HA   1 
ATOM   3606 H HB2  . LEU A 1 234 ? 6.92115  13.14947  16.73321  1.000 18.88326  ? 229 LEU A HB2  1 
ATOM   3607 H HB3  . LEU A 1 234 ? 7.85695  14.34335  17.20686  1.000 18.88326  ? 229 LEU A HB3  1 
ATOM   3608 H HG   . LEU A 1 234 ? 8.45465  12.85916  19.04841  1.000 35.71548  ? 229 LEU A HG   1 
ATOM   3609 H HD11 . LEU A 1 234 ? 7.54111  10.95398  17.15142  1.000 30.25486  ? 229 LEU A HD11 1 
ATOM   3610 H HD12 . LEU A 1 234 ? 8.19937  10.58423  18.54910  1.000 30.25486  ? 229 LEU A HD12 1 
ATOM   3611 H HD13 . LEU A 1 234 ? 6.76612  11.26767  18.50216  1.000 30.25486  ? 229 LEU A HD13 1 
ATOM   3612 H HD21 . LEU A 1 234 ? 9.55766  12.26297  16.53751  1.000 46.13247  ? 229 LEU A HD21 1 
ATOM   3613 H HD22 . LEU A 1 234 ? 10.07024 13.41281  17.50634  1.000 46.13247  ? 229 LEU A HD22 1 
ATOM   3614 H HD23 . LEU A 1 234 ? 10.22185 11.88972  17.93143  1.000 46.13247  ? 229 LEU A HD23 1 
ATOM   3615 N N    . TRP A 1 235 ? 7.21504  15.84473  19.81689  1.000 29.17106  ? 230 TRP A N    1 
ATOM   3616 C CA   . TRP A 1 235 ? 7.83402  16.29736  21.06298  1.000 22.35681  ? 230 TRP A CA   1 
ATOM   3617 C C    . TRP A 1 235 ? 6.80405  16.75710  22.08773  1.000 29.37862  ? 230 TRP A C    1 
ATOM   3618 O O    . TRP A 1 235 ? 7.19066  17.14029  23.19744  1.000 27.89644  ? 230 TRP A O    1 
ATOM   3619 C CB   . TRP A 1 235 ? 8.82982  17.44521  20.80702  1.000 18.54665  ? 230 TRP A CB   1 
ATOM   3620 C CG   . TRP A 1 235 ? 10.04363 17.10969  19.96003  1.000 25.02416  ? 230 TRP A CG   1 
ATOM   3621 C CD1  . TRP A 1 235 ? 10.58791 15.88754  19.78174  1.000 23.90227  ? 230 TRP A CD1  1 
ATOM   3622 C CD2  . TRP A 1 235 ? 10.84976 18.02598  19.18208  1.000 20.21204  ? 230 TRP A CD2  1 
ATOM   3623 N NE1  . TRP A 1 235 ? 11.66058 15.95805  18.92261  1.000 22.92944  ? 230 TRP A NE1  1 
ATOM   3624 C CE2  . TRP A 1 235 ? 11.85592 17.26282  18.55345  1.000 34.69429  ? 230 TRP A CE2  1 
ATOM   3625 C CE3  . TRP A 1 235 ? 10.79583 19.40134  18.93749  1.000 11.82360  ? 230 TRP A CE3  1 
ATOM   3626 C CZ2  . TRP A 1 235 ? 12.82884 17.83396  17.70875  1.000 22.24009  ? 230 TRP A CZ2  1 
ATOM   3627 C CZ3  . TRP A 1 235 ? 11.74711 19.97885  18.09610  1.000 14.62023  ? 230 TRP A CZ3  1 
ATOM   3628 C CH2  . TRP A 1 235 ? 12.76458 19.19324  17.50220  1.000 31.25582  ? 230 TRP A CH2  1 
ATOM   3629 H H    . TRP A 1 235 ? 7.19492  16.43035  19.18741  1.000 35.02767  ? 230 TRP A H    1 
ATOM   3630 H HA   . TRP A 1 235 ? 8.33790  15.55478  21.43119  1.000 26.85057  ? 230 TRP A HA   1 
ATOM   3631 H HB2  . TRP A 1 235 ? 8.35587  18.16034  20.35440  1.000 22.27838  ? 230 TRP A HB2  1 
ATOM   3632 H HB3  . TRP A 1 235 ? 9.15865  17.75616  21.66497  1.000 22.27838  ? 230 TRP A HB3  1 
ATOM   3633 H HD1  . TRP A 1 235 ? 10.28094 15.10692  20.18335  1.000 28.70512  ? 230 TRP A HD1  1 
ATOM   3634 H HE1  . TRP A 1 235 ? 12.13311 15.28947  18.65934  1.000 27.53773  ? 230 TRP A HE1  1 
ATOM   3635 H HE3  . TRP A 1 235 ? 10.13472 19.92429  19.33038  1.000 14.21072  ? 230 TRP A HE3  1 
ATOM   3636 H HZ2  . TRP A 1 235 ? 13.48714 17.31385  17.30746  1.000 26.71051  ? 230 TRP A HZ2  1 
ATOM   3637 H HZ3  . TRP A 1 235 ? 11.71254 20.89194  17.92298  1.000 17.56667  ? 230 TRP A HZ3  1 
ATOM   3638 H HH2  . TRP A 1 235 ? 13.40129 19.60339  16.96250  1.000 37.52938  ? 230 TRP A HH2  1 
ATOM   3639 N N    . THR A 1 236 ? 5.51924  16.74969  21.73511  1.000 30.57269  ? 231 THR A N    1 
ATOM   3640 C CA   . THR A 1 236 ? 4.45231  17.10050  22.66690  1.000 37.96700  ? 231 THR A CA   1 
ATOM   3641 C C    . THR A 1 236 ? 3.48802  15.93957  22.88796  1.000 44.19386  ? 231 THR A C    1 
ATOM   3642 O O    . THR A 1 236 ? 2.26970  16.12146  22.77905  1.000 51.60320  ? 231 THR A O    1 
ATOM   3643 C CB   . THR A 1 236 ? 3.59771  18.27020  22.17849  1.000 31.48517  ? 231 THR A CB   1 
ATOM   3644 O OG1  . THR A 1 236 ? 2.81179  17.82499  21.06196  1.000 52.23060  ? 231 THR A OG1  1 
ATOM   3645 C CG2  . THR A 1 236 ? 4.45263  19.46457  21.78230  1.000 18.06238  ? 231 THR A CG2  1 
ATOM   3646 H H    . THR A 1 236 ? 5.23653  16.54181  20.94996  1.000 36.70963  ? 231 THR A H    1 
ATOM   3647 H HA   . THR A 1 236 ? 4.88370  17.34006  23.50202  1.000 45.58280  ? 231 THR A HA   1 
ATOM   3648 H HB   . THR A 1 236 ? 3.01561  18.57300  22.89289  1.000 37.80460  ? 231 THR A HB   1 
ATOM   3649 H HG1  . THR A 1 236 ? 2.22021  17.28865  21.32270  1.000 62.69912  ? 231 THR A HG1  1 
ATOM   3650 H HG21 . THR A 1 236 ? 5.08071  19.20766  21.08919  1.000 21.69726  ? 231 THR A HG21 1 
ATOM   3651 H HG22 . THR A 1 236 ? 3.88904  20.17939  21.44718  1.000 21.69726  ? 231 THR A HG22 1 
ATOM   3652 H HG23 . THR A 1 236 ? 4.94744  19.78806  22.55134  1.000 21.69726  ? 231 THR A HG23 1 
ATOM   3653 N N    . ASP B 2 2   ? 10.28577 6.95177   18.17741  1.000 74.13589  ? 361 ASP B N    1 
ATOM   3654 C CA   . ASP B 2 2   ? 11.38651 6.99158   17.21420  1.000 57.86271  ? 361 ASP B CA   1 
ATOM   3655 C C    . ASP B 2 2   ? 12.08021 8.36250   17.24644  1.000 58.33836  ? 361 ASP B C    1 
ATOM   3656 O O    . ASP B 2 2   ? 11.61294 9.27771   17.92432  1.000 68.76475  ? 361 ASP B O    1 
ATOM   3657 C CB   . ASP B 2 2   ? 10.87587 6.66453   15.80320  1.000 64.66286  ? 361 ASP B CB   1 
ATOM   3658 C CG   . ASP B 2 2   ? 9.79616  7.62423   15.32927  1.000 86.91783  ? 361 ASP B CG   1 
ATOM   3659 O OD1  . ASP B 2 2   ? 8.92318  7.99370   16.14617  1.000 96.84597  ? 361 ASP B OD1  1 
ATOM   3660 O OD2  . ASP B 2 2   ? 9.83261  8.01610   14.13943  1.000 100.79271 ? 361 ASP B OD2  1 
ATOM   3661 H H    . ASP B 2 2   ? 9.52610  6.75298   17.82468  1.000 88.98547  ? 361 ASP B H    1 
ATOM   3662 H HA   . ASP B 2 2   ? 12.04791 6.32027   17.44398  1.000 69.45766  ? 361 ASP B HA   1 
ATOM   3663 H HB2  . ASP B 2 2   ? 11.61696 6.71563   15.17943  1.000 77.61783  ? 361 ASP B HB2  1 
ATOM   3664 H HB3  . ASP B 2 2   ? 10.50247 5.76928   15.80212  1.000 77.61783  ? 361 ASP B HB3  1 
ATOM   3665 N N    . ARG B 2 3   ? 13.19640 8.49173   16.52423  1.000 49.74161  ? 362 ARG B N    1 
ATOM   3666 C CA   . ARG B 2 3   ? 14.01760 9.69344   16.57968  1.000 43.02531  ? 362 ARG B CA   1 
ATOM   3667 C C    . ARG B 2 3   ? 13.44505 10.80406  15.69114  1.000 46.40590  ? 362 ARG B C    1 
ATOM   3668 O O    . ARG B 2 3   ? 12.59779 10.57215  14.82061  1.000 44.34595  ? 362 ARG B O    1 
ATOM   3669 C CB   . ARG B 2 3   ? 15.45702 9.37605   16.16268  1.000 29.69145  ? 362 ARG B CB   1 
ATOM   3670 H H    . ARG B 2 3   ? 13.49927 7.88942   15.99030  1.000 59.71233  ? 362 ARG B H    1 
ATOM   3671 H HA   . ARG B 2 3   ? 14.02770 10.02508  17.49117  1.000 51.65277  ? 362 ARG B HA   1 
ATOM   3672 N N    . SER B 2 4   ? 13.93895 12.02118  15.91568  1.000 53.31226  ? 363 SER B N    1 
ATOM   3673 C CA   . SER B 2 4   ? 13.43880 13.20587  15.23330  1.000 34.19766  ? 363 SER B CA   1 
ATOM   3674 C C    . SER B 2 4   ? 13.90820 13.29434  13.77407  1.000 35.63005  ? 363 SER B C    1 
ATOM   3675 O O    . SER B 2 4   ? 14.96692 12.77349  13.38828  1.000 22.59614  ? 363 SER B O    1 
ATOM   3676 C CB   . SER B 2 4   ? 13.87099 14.47001  15.99323  1.000 30.73381  ? 363 SER B CB   1 
ATOM   3677 O OG   . SER B 2 4   ? 13.82366 14.31427  17.39989  1.000 28.39473  ? 363 SER B OG   1 
ATOM   3678 H H    . SER B 2 4   ? 14.57573 12.18755  16.46924  1.000 63.99712  ? 363 SER B H    1 
ATOM   3679 H HA   . SER B 2 4   ? 12.47027 13.15759  15.21080  1.000 41.05960  ? 363 SER B HA   1 
ATOM   3680 H HB2  . SER B 2 4   ? 14.78202 14.68475  15.73866  1.000 36.90297  ? 363 SER B HB2  1 
ATOM   3681 H HB3  . SER B 2 4   ? 13.27724 15.19564  15.74460  1.000 36.90297  ? 363 SER B HB3  1 
ATOM   3682 H HG   . SER B 2 4   ? 14.15933 14.98683  17.77486  1.000 34.09608  ? 363 SER B HG   1 
ATOM   3683 N N    . SER B 2 5   ? 13.10866 13.99119  12.96756  1.000 17.39383  ? 364 SER B N    1 
ATOM   3684 C CA   . SER B 2 5   ? 13.38402 14.20735  11.55820  1.000 16.75615  ? 364 SER B CA   1 
ATOM   3685 C C    . SER B 2 5   ? 14.32193 15.39098  11.31653  1.000 16.09365  ? 364 SER B C    1 
ATOM   3686 O O    . SER B 2 5   ? 14.05683 16.48426  11.78620  1.000 19.72544  ? 364 SER B O    1 
ATOM   3687 C CB   . SER B 2 5   ? 12.07649 14.45521  10.78702  1.000 21.78730  ? 364 SER B CB   1 
ATOM   3688 O OG   . SER B 2 5   ? 11.23743 13.31485  10.71702  1.000 42.16780  ? 364 SER B OG   1 
ATOM   3689 H H    . SER B 2 5   ? 12.37604 14.35999  13.22612  1.000 20.89500  ? 364 SER B H    1 
ATOM   3690 H HA   . SER B 2 5   ? 13.81741 13.40751  11.22156  1.000 20.12979  ? 364 SER B HA   1 
ATOM   3691 H HB2  . SER B 2 5   ? 11.58926 15.16568  11.23281  1.000 26.16716  ? 364 SER B HB2  1 
ATOM   3692 H HB3  . SER B 2 5   ? 12.30186 14.72422  9.88273   1.000 26.16716  ? 364 SER B HB3  1 
ATOM   3693 H HG   . SER B 2 5   ? 10.50167 13.52053  10.36782  1.000 50.62376  ? 364 SER B HG   1 
HETATM 3694 N N    . SEP B 2 6   ? 15.40057 15.15099  10.56484  1.000 27.63189  ? 365 SEP B N    1 
HETATM 3695 C CA   . SEP B 2 6   ? 16.35653 16.18335  10.15321  1.000 19.92849  ? 365 SEP B CA   1 
HETATM 3696 C CB   . SEP B 2 6   ? 17.80798 15.75403  10.50220  1.000 30.24195  ? 365 SEP B CB   1 
HETATM 3697 O OG   . SEP B 2 6   ? 18.27395 14.65057  9.73287   1.000 13.34248  ? 365 SEP B OG   1 
HETATM 3698 C C    . SEP B 2 6   ? 16.19678 16.48200  8.63514   1.000 12.83505  ? 365 SEP B C    1 
HETATM 3699 O O    . SEP B 2 6   ? 15.37093 15.88619  7.94612   1.000 24.97867  ? 365 SEP B O    1 
HETATM 3700 P P    . SEP B 2 6   ? 19.70911 14.08650  10.18455  1.000 14.70312  ? 365 SEP B P    1 
HETATM 3701 O O1P  . SEP B 2 6   ? 20.00686 12.79714  9.28299   1.000 29.90864  ? 365 SEP B O1P  1 
HETATM 3702 O O2P  . SEP B 2 6   ? 20.84322 15.20279  9.97085   1.000 19.04662  ? 365 SEP B O2P  1 
HETATM 3703 O O3P  . SEP B 2 6   ? 19.57009 13.59960  11.71339  1.000 27.96668  ? 365 SEP B O3P  1 
HETATM 3704 H HA   . SEP B 2 6   ? 16.18801 17.01584  10.64204  1.000 23.93659  ? 365 SEP B HA   1 
HETATM 3705 H HB2  . SEP B 2 6   ? 17.83569 15.50584  11.43950  1.000 36.31274  ? 365 SEP B HB2  1 
HETATM 3706 H HB3  . SEP B 2 6   ? 18.39627 16.50828  10.34120  1.000 36.31274  ? 365 SEP B HB3  1 
ATOM   3707 N N    . ALA B 2 7   ? 17.00423 17.39218  8.11455   1.000 26.10446  ? 366 ALA B N    1 
ATOM   3708 C CA   . ALA B 2 7   ? 16.73300 17.97742  6.80549   1.000 24.16082  ? 366 ALA B CA   1 
ATOM   3709 C C    . ALA B 2 7   ? 17.16895 17.11447  5.61123   1.000 31.91772  ? 366 ALA B C    1 
ATOM   3710 O O    . ALA B 2 7   ? 18.30622 16.66446  5.57061   1.000 21.42943  ? 366 ALA B O    1 
ATOM   3711 C CB   . ALA B 2 7   ? 17.41139 19.33742  6.72801   1.000 2.75906   ? 366 ALA B CB   1 
ATOM   3712 H H    . ALA B 2 7   ? 17.71530 17.68925  8.49629   1.000 31.34775  ? 366 ALA B H    1 
ATOM   3713 H HA   . ALA B 2 7   ? 15.77010 18.06103  6.72345   1.000 29.01539  ? 366 ALA B HA   1 
ATOM   3714 H HB1  . ALA B 2 7   ? 17.46636 19.61043  5.79885   1.000 3.33327   ? 366 ALA B HB1  1 
ATOM   3715 H HB2  . ALA B 2 7   ? 18.30217 19.26795  7.10561   1.000 3.33327   ? 366 ALA B HB2  1 
ATOM   3716 H HB3  . ALA B 2 7   ? 16.88799 19.98054  7.23134   1.000 3.33327   ? 366 ALA B HB3  1 
ATOM   3717 N N    . PRO B 2 8   ? 16.28758 16.97548  4.61685   1.000 17.80790  ? 367 PRO B N    1 
ATOM   3718 C CA   . PRO B 2 8   ? 16.42475 15.89928  3.63840   1.000 39.33501  ? 367 PRO B CA   1 
ATOM   3719 C C    . PRO B 2 8   ? 17.44231 16.17860  2.55921   1.000 30.40377  ? 367 PRO B C    1 
ATOM   3720 O O    . PRO B 2 8   ? 17.85777 17.31332  2.32594   1.000 19.77367  ? 367 PRO B O    1 
ATOM   3721 C CB   . PRO B 2 8   ? 15.02109 15.80501  3.02575   1.000 32.99701  ? 367 PRO B CB   1 
ATOM   3722 C CG   . PRO B 2 8   ? 14.51880 17.16026  3.08611   1.000 25.15252  ? 367 PRO B CG   1 
ATOM   3723 C CD   . PRO B 2 8   ? 15.04132 17.72377  4.38801   1.000 36.99564  ? 367 PRO B CD   1 
ATOM   3724 H HA   . PRO B 2 8   ? 16.66706 15.07798  4.09408   1.000 47.22441  ? 367 PRO B HA   1 
ATOM   3725 H HB2  . PRO B 2 8   ? 15.07720 15.49256  2.10917   1.000 39.61881  ? 367 PRO B HB2  1 
ATOM   3726 H HB3  . PRO B 2 8   ? 14.46853 15.20288  3.54828   1.000 39.61881  ? 367 PRO B HB3  1 
ATOM   3727 H HG2  . PRO B 2 8   ? 14.85293 17.66901  2.33084   1.000 30.20542  ? 367 PRO B HG2  1 
ATOM   3728 H HG3  . PRO B 2 8   ? 13.54887 17.15243  3.07782   1.000 30.20542  ? 367 PRO B HG3  1 
ATOM   3729 H HD2  . PRO B 2 8   ? 15.22111 18.67324  4.30391   1.000 44.41717  ? 367 PRO B HD2  1 
ATOM   3730 H HD3  . PRO B 2 8   ? 14.40997 17.56814  5.10779   1.000 44.41717  ? 367 PRO B HD3  1 
ATOM   3731 N N    . ASN B 2 9   ? 17.83588 15.06956  1.90730   1.000 76.45390  ? 368 ASN B N    1 
ATOM   3732 C CA   . ASN B 2 9   ? 18.74292 15.07771  0.76486   1.000 48.11453  ? 368 ASN B CA   1 
ATOM   3733 C C    . ASN B 2 9   ? 18.12235 15.87024  -0.36758  1.000 49.93298  ? 368 ASN B C    1 
ATOM   3734 O O    . ASN B 2 9   ? 17.02148 15.54912  -0.82869  1.000 24.28530  ? 368 ASN B O    1 
ATOM   3735 C CB   . ASN B 2 9   ? 19.02270 13.64735  0.29040   1.000 70.65972  ? 368 ASN B CB   1 
ATOM   3736 C CG   . ASN B 2 9   ? 20.30164 13.06558  0.86144   1.000 37.88065  ? 368 ASN B CG   1 
ATOM   3737 O OD1  . ASN B 2 9   ? 21.21180 13.79223  1.25505   1.000 35.65534  ? 368 ASN B OD1  1 
ATOM   3738 N ND2  . ASN B 2 9   ? 20.38923 11.74116  0.86854   1.000 45.12862  ? 368 ASN B ND2  1 
ATOM   3739 H H    . ASN B 2 9   ? 17.57906 14.27679  2.11980   1.000 91.76709  ? 368 ASN B H    1 
ATOM   3740 H HA   . ASN B 2 9   ? 19.58504 15.48230  1.02569   1.000 57.75983  ? 368 ASN B HA   1 
ATOM   3741 H HB2  . ASN B 2 9   ? 18.28782 13.07634  0.56391   1.000 84.81406  ? 368 ASN B HB2  1 
ATOM   3742 H HB3  . ASN B 2 9   ? 19.10115 13.64686  -0.67642  1.000 84.81406  ? 368 ASN B HB3  1 
ATOM   3743 H HD21 . ASN B 2 9   ? 21.09304 11.35843  1.18123   1.000 54.17675  ? 368 ASN B HD21 1 
ATOM   3744 H HD22 . ASN B 2 9   ? 19.74217 11.26577  0.56046   1.000 54.17675  ? 368 ASN B HD22 1 
ATOM   3745 N N    . VAL B 2 10  ? 18.89651 16.83579  -0.86577  1.000 57.14591  ? 369 VAL B N    1 
ATOM   3746 C CA   . VAL B 2 10  ? 18.37159 17.96866  -1.62210  1.000 66.83313  ? 369 VAL B CA   1 
ATOM   3747 C C    . VAL B 2 10  ? 17.53085 17.51613  -2.82026  1.000 98.94330  ? 369 VAL B C    1 
ATOM   3748 O O    . VAL B 2 10  ? 16.38183 17.95263  -2.98530  1.000 82.67509  ? 369 VAL B O    1 
ATOM   3749 C CB   . VAL B 2 10  ? 19.54722 18.86881  -2.04772  1.000 76.28371  ? 369 VAL B CB   1 
ATOM   3750 C CG1  . VAL B 2 10  ? 20.49747 19.09861  -0.85440  1.000 56.66487  ? 369 VAL B CG1  1 
ATOM   3751 C CG2  . VAL B 2 10  ? 20.32260 18.24824  -3.21554  1.000 66.37075  ? 369 VAL B CG2  1 
ATOM   3752 H H    . VAL B 2 10  ? 19.75161 16.85814  -0.77693  1.000 68.59749  ? 369 VAL B H    1 
ATOM   3753 H HA   . VAL B 2 10  ? 17.77099 18.47317  -1.05144  1.000 80.22215  ? 369 VAL B HA   1 
ATOM   3754 H HB   . VAL B 2 10  ? 19.19004 19.72175  -2.34067  1.000 91.56285  ? 369 VAL B HB   1 
ATOM   3755 H HG11 . VAL B 2 10  ? 20.01828 18.91999  -0.03016  1.000 68.02025  ? 369 VAL B HG11 1 
ATOM   3756 H HG12 . VAL B 2 10  ? 21.25485 18.49776  -0.93355  1.000 68.02025  ? 369 VAL B HG12 1 
ATOM   3757 H HG13 . VAL B 2 10  ? 20.80288 20.01919  -0.86662  1.000 68.02025  ? 369 VAL B HG13 1 
ATOM   3758 H HG21 . VAL B 2 10  ? 21.20784 18.64309  -3.25216  1.000 79.66730  ? 369 VAL B HG21 1 
ATOM   3759 H HG22 . VAL B 2 10  ? 20.39290 17.29109  -3.07480  1.000 79.66730  ? 369 VAL B HG22 1 
ATOM   3760 H HG23 . VAL B 2 10  ? 19.84625 18.42704  -4.04139  1.000 79.66730  ? 369 VAL B HG23 1 
ATOM   3761 N N    . HIS B 2 11  ? 18.08491 16.65433  -3.67760  1.000 99.73238  ? 370 HIS B N    1 
ATOM   3762 C CA   . HIS B 2 11  ? 17.44299 16.27146  -4.94377  1.000 64.30290  ? 370 HIS B CA   1 
ATOM   3763 C C    . HIS B 2 11  ? 16.21253 15.39402  -4.71543  1.000 85.92993  ? 370 HIS B C    1 
ATOM   3764 O O    . HIS B 2 11  ? 15.34972 15.26513  -5.58796  1.000 69.24446  ? 370 HIS B O    1 
ATOM   3765 C CB   . HIS B 2 11  ? 18.44358 15.54214  -5.86382  1.000 80.94356  ? 370 HIS B CB   1 
ATOM   3766 C CG   . HIS B 2 11  ? 18.92457 14.22157  -5.33029  1.000 106.29469 ? 370 HIS B CG   1 
ATOM   3767 N ND1  . HIS B 2 11  ? 18.70633 13.81090  -4.02982  1.000 76.29245  ? 370 HIS B ND1  1 
ATOM   3768 C CD2  . HIS B 2 11  ? 19.61413 13.21854  -5.92857  1.000 96.77370  ? 370 HIS B CD2  1 
ATOM   3769 C CE1  . HIS B 2 11  ? 19.24794 12.61838  -3.84922  1.000 81.12271  ? 370 HIS B CE1  1 
ATOM   3770 N NE2  . HIS B 2 11  ? 19.80498 12.23610  -4.98632  1.000 78.40530  ? 370 HIS B NE2  1 
ATOM   3771 H H    . HIS B 2 11  ? 18.84366 16.27040  -3.54922  1.000 119.70126 ? 370 HIS B H    1 
ATOM   3772 H HA   . HIS B 2 11  ? 17.14928 17.08033  -5.39140  1.000 77.18589  ? 370 HIS B HA   1 
ATOM   3773 H HB2  . HIS B 2 11  ? 18.01460 15.37540  -6.71768  1.000 97.15467  ? 370 HIS B HB2  1 
ATOM   3774 H HB3  . HIS B 2 11  ? 19.22053 16.10942  -5.98806  1.000 97.15467  ? 370 HIS B HB3  1 
ATOM   3775 H HD2  . HIS B 2 11  ? 19.90395 13.19907  -6.81204  1.000 116.15084 ? 370 HIS B HD2  1 
ATOM   3776 H HE1  . HIS B 2 11  ? 19.23879 12.13109  -3.05715  1.000 97.36966  ? 370 HIS B HE1  1 
ATOM   3777 H HE2  . HIS B 2 11  ? 20.21924 11.49356  -5.11520  1.000 94.10875  ? 370 HIS B HE2  1 
HETATM 3778 O O    . HOH C 3 .   ? 28.17420 15.45927  3.91700   1.000 78.82456  ? 301 HOH A O    1 
HETATM 3779 O O    . HOH C 3 .   ? 7.35560  23.42258  29.82460  1.000 9.55331   ? 302 HOH A O    1 
HETATM 3780 O O    . HOH C 3 .   ? 11.42588 21.46700  -3.90408  1.000 28.07311  ? 303 HOH A O    1 
HETATM 3781 O O    . HOH C 3 .   ? 40.58592 33.34230  1.94906   1.000 35.35000  ? 304 HOH A O    1 
HETATM 3782 O O    . HOH C 3 .   ? 24.86510 18.95095  6.08536   1.000 28.41971  ? 305 HOH A O    1 
HETATM 3783 O O    . HOH C 3 .   ? 25.66746 29.35437  20.84894  1.000 32.18507  ? 306 HOH A O    1 
HETATM 3784 O O    . HOH C 3 .   ? 18.78264 15.39998  24.27094  1.000 47.55304  ? 307 HOH A O    1 
HETATM 3785 O O    . HOH C 3 .   ? 38.80364 16.59464  13.26570  1.000 28.79676  ? 308 HOH A O    1 
HETATM 3786 O O    . HOH C 3 .   ? 20.58105 24.12446  24.43427  1.000 21.54813  ? 309 HOH A O    1 
HETATM 3787 O O    . HOH C 3 .   ? 37.59177 27.84097  -2.22263  1.000 16.81671  ? 310 HOH A O    1 
HETATM 3788 O O    . HOH C 3 .   ? 20.27129 1.27485   12.92965  1.000 25.67845  ? 311 HOH A O    1 
HETATM 3789 O O    . HOH C 3 .   ? 4.93500  32.15795  17.59300  1.000 28.30839  ? 312 HOH A O    1 
HETATM 3790 O O    . HOH C 3 .   ? 42.39100 21.55482  -16.16775 0.50  2.55991   ? 313 HOH A O    1 
HETATM 3791 O O    . HOH C 3 .   ? 9.84473  35.92432  0.89792   1.000 20.28918  ? 314 HOH A O    1 
HETATM 3792 O O    . HOH C 3 .   ? 19.71079 25.58280  8.95864   1.000 11.30683  ? 315 HOH A O    1 
HETATM 3793 O O    . HOH C 3 .   ? 11.03117 31.71295  20.74536  1.000 18.40553  ? 316 HOH A O    1 
HETATM 3794 O O    . HOH C 3 .   ? 9.27627  15.45889  24.22769  1.000 32.90424  ? 317 HOH A O    1 
HETATM 3795 O O    . HOH C 3 .   ? 24.72039 -11.88900 26.50602  1.000 50.71139  ? 318 HOH A O    1 
HETATM 3796 O O    . HOH C 3 .   ? 1.08324  16.13923  13.47341  1.000 26.70827  ? 319 HOH A O    1 
HETATM 3797 O O    . HOH C 3 .   ? 22.429   25.194    -9.644    1.000 37.32450  ? 320 HOH A O    1 
HETATM 3798 O O    . HOH C 3 .   ? 32.151   28.046    23.476    1.000 38.07550  ? 321 HOH A O    1 
HETATM 3799 O O    . HOH C 3 .   ? 32.66786 27.66092  -2.48491  1.000 15.26953  ? 322 HOH A O    1 
HETATM 3800 O O    . HOH C 3 .   ? 17.77135 31.01640  22.02797  1.000 18.47533  ? 323 HOH A O    1 
HETATM 3801 O O    . HOH C 3 .   ? 26.68639 33.08329  -5.07200  1.000 16.70279  ? 324 HOH A O    1 
HETATM 3802 O O    . HOH C 3 .   ? 36.52839 6.63877   -14.06161 1.000 11.81827  ? 325 HOH A O    1 
HETATM 3803 O O    . HOH C 3 .   ? 33.764   16.844    -19.938   1.000 31.59031  ? 326 HOH A O    1 
HETATM 3804 O O    . HOH C 3 .   ? 31.46184 11.79238  27.75101  1.000 44.23898  ? 327 HOH A O    1 
HETATM 3805 O O    . HOH C 3 .   ? 41.640   27.049    -2.059    1.000 25.81920  ? 328 HOH A O    1 
HETATM 3806 O O    . HOH C 3 .   ? 15.90273 15.05454  25.09018  1.000 49.70601  ? 329 HOH A O    1 
HETATM 3807 O O    . HOH C 3 .   ? 36.59527 25.05461  9.61248   1.000 23.41659  ? 330 HOH A O    1 
HETATM 3808 O O    . HOH C 3 .   ? 36.09011 22.31103  9.87602   1.000 29.63873  ? 331 HOH A O    1 
HETATM 3809 O O    . HOH C 3 .   ? 22.077   0.894     -9.139    1.000 20.55493  ? 332 HOH A O    1 
HETATM 3810 O O    . HOH C 3 .   ? 9.57169  13.70093  12.95619  1.000 32.02133  ? 333 HOH A O    1 
HETATM 3811 O O    . HOH C 3 .   ? 26.88146 9.38043   14.46201  1.000 12.83575  ? 334 HOH A O    1 
HETATM 3812 O O    . HOH C 3 .   ? 27.19334 38.90089  -1.55825  1.000 19.68899  ? 335 HOH A O    1 
HETATM 3813 O O    . HOH C 3 .   ? 7.65189  30.81254  19.52315  1.000 31.33823  ? 336 HOH A O    1 
HETATM 3814 O O    . HOH C 3 .   ? 6.69421  38.78206  -4.49973  1.000 29.48225  ? 337 HOH A O    1 
HETATM 3815 O O    . HOH C 3 .   ? 13.81672 30.85445  13.77211  1.000 19.17713  ? 338 HOH A O    1 
HETATM 3816 O O    . HOH C 3 .   ? 1.95289  14.12482  20.77872  1.000 28.00218  ? 339 HOH A O    1 
HETATM 3817 O O    . HOH C 3 .   ? 38.00771 -3.20162  17.58907  1.000 35.01198  ? 340 HOH A O    1 
HETATM 3818 O O    . HOH C 3 .   ? 6.91415  28.93821  -9.97798  1.000 26.70987  ? 341 HOH A O    1 
HETATM 3819 O O    . HOH C 3 .   ? 34.68786 -15.53020 21.95761  1.000 27.79987  ? 342 HOH A O    1 
HETATM 3820 O O    . HOH C 3 .   ? 41.98987 12.78286  -3.11429  1.000 40.43878  ? 343 HOH A O    1 
HETATM 3821 O O    . HOH C 3 .   ? 29.50729 22.31768  -12.90108 1.000 29.92872  ? 344 HOH A O    1 
HETATM 3822 O O    . HOH C 3 .   ? 36.24327 4.90652   20.29671  1.000 32.26633  ? 345 HOH A O    1 
HETATM 3823 O O    . HOH C 3 .   ? 19.15396 29.33735  20.75400  1.000 35.52442  ? 346 HOH A O    1 
HETATM 3824 O O    . HOH C 3 .   ? 2.15102  22.92882  -5.63745  1.000 49.32012  ? 347 HOH A O    1 
HETATM 3825 O O    . HOH C 3 .   ? 20.95799 14.06447  15.74404  1.000 15.52807  ? 348 HOH A O    1 
HETATM 3826 O O    . HOH C 3 .   ? 42.223   17.556    1.583     1.000 31.67006  ? 349 HOH A O    1 
HETATM 3827 O O    . HOH C 3 .   ? 37.61690 23.37949  -7.11531  1.000 9.99849   ? 350 HOH A O    1 
HETATM 3828 O O    . HOH C 3 .   ? 27.61589 3.74915   4.21767   1.000 21.60394  ? 351 HOH A O    1 
HETATM 3829 O O    . HOH C 3 .   ? 23.51429 7.63900   15.17364  1.000 30.32905  ? 352 HOH A O    1 
HETATM 3830 O O    . HOH C 3 .   ? 33.35149 7.49327   21.96784  1.000 25.85165  ? 353 HOH A O    1 
HETATM 3831 O O    . HOH C 3 .   ? 43.46295 21.07911  -17.95937 1.000 16.84114  ? 354 HOH A O    1 
HETATM 3832 O O    . HOH C 3 .   ? 36.68034 6.31559   7.27374   1.000 24.35816  ? 355 HOH A O    1 
HETATM 3833 O O    . HOH C 3 .   ? 42.33500 17.35496  -7.02120  1.000 11.42775  ? 356 HOH A O    1 
HETATM 3834 O O    . HOH C 3 .   ? 42.526   23.627    -10.563   1.000 33.27834  ? 357 HOH A O    1 
HETATM 3835 O O    . HOH C 3 .   ? 34.81245 28.72027  -0.86644  1.000 15.32222  ? 358 HOH A O    1 
HETATM 3836 O O    . HOH C 3 .   ? 7.49757  36.89566  7.90356   1.000 28.02555  ? 359 HOH A O    1 
HETATM 3837 O O    . HOH C 3 .   ? 8.58232  13.16240  9.36093   1.000 36.46419  ? 360 HOH A O    1 
HETATM 3838 O O    . HOH C 3 .   ? 27.43977 0.76888   22.83764  1.000 24.24360  ? 361 HOH A O    1 
HETATM 3839 O O    . HOH C 3 .   ? 2.46138  15.64196  11.75070  1.000 32.21188  ? 362 HOH A O    1 
HETATM 3840 O O    . HOH C 3 .   ? 29.99954 9.79747   28.41134  1.000 41.15051  ? 363 HOH A O    1 
HETATM 3841 O O    . HOH C 3 .   ? 32.89709 25.32081  15.57398  1.000 20.55813  ? 364 HOH A O    1 
HETATM 3842 O O    . HOH C 3 .   ? 41.03091 30.87442  -10.32037 1.000 45.39981  ? 365 HOH A O    1 
HETATM 3843 O O    . HOH C 3 .   ? 29.59768 21.68941  26.08617  1.000 27.33309  ? 366 HOH A O    1 
HETATM 3844 O O    . HOH C 3 .   ? 34.64249 22.40323  -13.93545 1.000 17.79571  ? 367 HOH A O    1 
HETATM 3845 O O    . HOH C 3 .   ? 29.93990 -3.79624  26.09541  1.000 27.92212  ? 368 HOH A O    1 
HETATM 3846 O O    . HOH C 3 .   ? 31.08399 5.36902   21.78715  1.000 22.24805  ? 369 HOH A O    1 
HETATM 3847 O O    . HOH C 3 .   ? 23.03997 16.61856  26.96011  1.000 32.41453  ? 370 HOH A O    1 
HETATM 3848 O O    . HOH C 3 .   ? 44.088   23.126    -3.828    1.000 12.56780  ? 371 HOH A O    1 
HETATM 3849 O O    . HOH C 3 .   ? 14.96427 27.20625  26.84528  1.000 15.55873  ? 372 HOH A O    1 
HETATM 3850 O O    . HOH C 3 .   ? 0.00000  28.73993  16.16775  0.50  36.92188  ? 373 HOH A O    1 
HETATM 3851 O O    . HOH C 3 .   ? 2.083    38.661    6.812     1.000 13.97052  ? 374 HOH A O    1 
HETATM 3852 O O    . HOH C 3 .   ? 12.45998 27.99178  -3.78060  1.000 48.26980  ? 375 HOH A O    1 
HETATM 3853 O O    . HOH C 3 .   ? 12.45815 32.51985  0.13042   1.000 27.44053  ? 376 HOH A O    1 
HETATM 3854 O O    . HOH C 3 .   ? 39.76640 20.45763  -20.82948 1.000 36.18832  ? 377 HOH A O    1 
HETATM 3855 O O    . HOH C 3 .   ? 16.23140 31.54327  11.26155  1.000 26.11884  ? 378 HOH A O    1 
HETATM 3856 O O    . HOH C 3 .   ? 38.74904 27.51160  5.64709   1.000 13.78955  ? 379 HOH A O    1 
HETATM 3857 O O    . HOH C 3 .   ? 45.02915 18.55170  -9.22307  1.000 19.33332  ? 380 HOH A O    1 
HETATM 3858 O O    . HOH C 3 .   ? 40.306   -10.683   21.597    1.000 27.87534  ? 381 HOH A O    1 
HETATM 3859 O O    . HOH C 3 .   ? 25.90168 10.76470  23.09518  1.000 34.84791  ? 382 HOH A O    1 
HETATM 3860 O O    . HOH C 3 .   ? 33.40793 10.83401  18.52877  1.000 18.10253  ? 383 HOH A O    1 
HETATM 3861 O O    . HOH C 3 .   ? 38.22178 24.74412  -3.27222  1.000 9.26526   ? 384 HOH A O    1 
HETATM 3862 O O    . HOH C 3 .   ? 31.83788 30.47066  -2.81200  1.000 22.07413  ? 385 HOH A O    1 
HETATM 3863 O O    . HOH C 3 .   ? 30.26650 3.70440   -4.51965  1.000 13.81984  ? 386 HOH A O    1 
HETATM 3864 O O    . HOH C 3 .   ? 20.94731 38.27813  13.32349  1.000 23.03332  ? 387 HOH A O    1 
HETATM 3865 O O    . HOH C 3 .   ? 20.86126 6.89224   9.27891   1.000 37.72082  ? 388 HOH A O    1 
HETATM 3866 O O    . HOH C 3 .   ? 35.459   33.824    -6.397    1.000 28.17099  ? 389 HOH A O    1 
HETATM 3867 O O    . HOH C 3 .   ? 23.82823 26.67417  -1.53721  1.000 19.91807  ? 390 HOH A O    1 
HETATM 3868 O O    . HOH C 3 .   ? 40.30361 -7.00789  22.50986  1.000 34.01147  ? 391 HOH A O    1 
HETATM 3869 O O    . HOH C 3 .   ? 39.48516 11.59004  -3.75071  1.000 20.12291  ? 392 HOH A O    1 
HETATM 3870 O O    . HOH C 3 .   ? 40.02155 17.82050  29.97203  1.000 23.24881  ? 393 HOH A O    1 
HETATM 3871 O O    . HOH C 3 .   ? 18.644   24.256    28.703    1.000 15.79482  ? 394 HOH A O    1 
HETATM 3872 O O    . HOH C 3 .   ? 31.34031 -7.71984  23.29666  1.000 35.92688  ? 395 HOH A O    1 
HETATM 3873 O O    . HOH C 3 .   ? 13.27285 35.18838  14.77297  1.000 32.65115  ? 396 HOH A O    1 
HETATM 3874 O O    . HOH C 3 .   ? 37.89820 21.07182  -16.22517 1.000 21.72388  ? 397 HOH A O    1 
HETATM 3875 O O    . HOH C 3 .   ? 25.46335 4.04117   1.91533   1.000 34.86110  ? 398 HOH A O    1 
HETATM 3876 O O    . HOH C 3 .   ? 36.53463 20.19038  19.12272  1.000 34.20654  ? 399 HOH A O    1 
HETATM 3877 O O    . HOH C 3 .   ? 39.30878 25.57002  -0.96614  1.000 26.85040  ? 400 HOH A O    1 
HETATM 3878 O O    . HOH C 3 .   ? 18.73235 0.32001   -3.63830  1.000 38.57026  ? 401 HOH A O    1 
HETATM 3879 O O    . HOH C 3 .   ? 18.91244 8.23071   -0.88295  1.000 39.77594  ? 402 HOH A O    1 
HETATM 3880 O O    . HOH C 3 .   ? 28.02964 -2.04091  -5.84624  1.000 27.14018  ? 403 HOH A O    1 
HETATM 3881 O O    . HOH C 3 .   ? 34.557   27.751    -10.119   1.000 11.99861  ? 404 HOH A O    1 
HETATM 3882 O O    . HOH C 3 .   ? 11.44805 31.52748  9.50255   1.000 21.66038  ? 405 HOH A O    1 
HETATM 3883 O O    . HOH C 3 .   ? 12.34915 32.47883  11.38375  1.000 19.94872  ? 406 HOH A O    1 
HETATM 3884 O O    . HOH C 3 .   ? 24.25502 21.88844  4.37448   1.000 16.45714  ? 407 HOH A O    1 
HETATM 3885 O O    . HOH C 3 .   ? 27.98217 24.17067  24.47673  1.000 26.28770  ? 408 HOH A O    1 
HETATM 3886 O O    . HOH C 3 .   ? 22.22304 27.37997  21.94963  1.000 19.86873  ? 409 HOH A O    1 
HETATM 3887 O O    . HOH C 3 .   ? 12.13924 24.41306  -9.77122  1.000 36.38730  ? 410 HOH A O    1 
HETATM 3888 O O    . HOH C 3 .   ? 19.50998 32.58699  17.33524  1.000 34.40986  ? 411 HOH A O    1 
HETATM 3889 O O    . HOH C 3 .   ? 28.51163 18.24591  -15.54713 1.000 23.57864  ? 412 HOH A O    1 
HETATM 3890 O O    . HOH C 3 .   ? 37.53367 17.45026  14.07165  1.000 35.13262  ? 413 HOH A O    1 
HETATM 3891 O O    . HOH C 3 .   ? 24.31847 -0.10986  7.09895   1.000 29.81223  ? 414 HOH A O    1 
HETATM 3892 O O    . HOH C 3 .   ? 34.77394 7.99696   -0.57475  1.000 19.68156  ? 415 HOH A O    1 
HETATM 3893 O O    . HOH C 3 .   ? 30.31185 -11.07789 21.76558  1.000 29.32505  ? 416 HOH A O    1 
HETATM 3894 O O    . HOH C 3 .   ? 36.20603 10.26723  0.83162   1.000 23.33340  ? 417 HOH A O    1 
HETATM 3895 O O    . HOH C 3 .   ? -0.31720 37.65191  -2.44483  1.000 17.70196  ? 418 HOH A O    1 
HETATM 3896 O O    . HOH C 3 .   ? 7.73333  21.94035  27.41357  1.000 19.63423  ? 419 HOH A O    1 
HETATM 3897 O O    . HOH C 3 .   ? 24.92121 30.88333  -4.87164  1.000 26.46314  ? 420 HOH A O    1 
HETATM 3898 O O    . HOH C 3 .   ? 0.21431  32.84636  1.95123   1.000 24.58654  ? 421 HOH A O    1 
HETATM 3899 O O    . HOH C 3 .   ? 37.80701 15.55559  15.78269  1.000 40.30574  ? 422 HOH A O    1 
HETATM 3900 O O    . HOH C 3 .   ? 20.43992 10.96832  17.59935  1.000 34.04692  ? 423 HOH A O    1 
HETATM 3901 O O    . HOH C 3 .   ? 12.56784 27.31039  -7.35304  1.000 38.32198  ? 424 HOH A O    1 
HETATM 3902 O O    . HOH C 3 .   ? 26.99445 7.98206   22.88624  1.000 22.76847  ? 425 HOH A O    1 
HETATM 3903 O O    . HOH C 3 .   ? 8.83306  25.26348  24.99801  1.000 24.77808  ? 426 HOH A O    1 
HETATM 3904 O O    . HOH C 3 .   ? 35.91215 25.43794  15.26203  1.000 39.49307  ? 427 HOH A O    1 
HETATM 3905 O O    . HOH C 3 .   ? 20.029   1.994     -9.002    1.000 35.03854  ? 428 HOH A O    1 
HETATM 3906 O O    . HOH C 3 .   ? 26.714   -1.091    30.169    1.000 52.26438  ? 429 HOH A O    1 
HETATM 3907 O O    . HOH C 3 .   ? 40.79873 17.34551  9.82037   1.000 21.95046  ? 430 HOH A O    1 
HETATM 3908 O O    . HOH C 3 .   ? 3.89639  31.80225  -9.80346  1.000 26.15394  ? 431 HOH A O    1 
HETATM 3909 O O    . HOH C 3 .   ? 16.42661 8.85415   20.75953  1.000 41.15965  ? 432 HOH A O    1 
HETATM 3910 O O    . HOH C 3 .   ? 20.50805 28.23077  23.28018  1.000 31.11911  ? 433 HOH A O    1 
HETATM 3911 O O    . HOH C 3 .   ? 25.13030 38.07114  -0.04491  1.000 37.82236  ? 434 HOH A O    1 
HETATM 3912 O O    . HOH C 3 .   ? 21.94209 16.75357  -6.15840  1.000 57.37471  ? 435 HOH A O    1 
HETATM 3913 O O    . HOH C 3 .   ? 33.98488 -6.71995  26.03317  1.000 24.46231  ? 436 HOH A O    1 
HETATM 3914 O O    . HOH C 3 .   ? 38.30011 20.17838  -18.84662 1.000 33.04246  ? 437 HOH A O    1 
HETATM 3915 O O    . HOH C 3 .   ? 33.50964 4.78143   23.23974  1.000 32.82342  ? 438 HOH A O    1 
HETATM 3916 O O    . HOH C 3 .   ? 36.00735 -7.36864  26.09683  1.000 32.75885  ? 439 HOH A O    1 
HETATM 3917 O O    . HOH C 3 .   ? 22.69231 19.16270  -7.85602  1.000 21.90222  ? 440 HOH A O    1 
HETATM 3918 O O    . HOH C 3 .   ? 21.61836 10.86093  -18.11970 1.000 25.56153  ? 441 HOH A O    1 
HETATM 3919 O O    . HOH C 3 .   ? 10.307   35.854    17.695    1.000 27.87525  ? 442 HOH A O    1 
HETATM 3920 O O    . HOH C 3 .   ? 30.12965 3.34389   3.78621   1.000 26.48495  ? 443 HOH A O    1 
HETATM 3921 O O    . HOH C 3 .   ? 13.38664 31.44441  18.79690  1.000 30.84934  ? 444 HOH A O    1 
HETATM 3922 O O    . HOH C 3 .   ? 13.22784 24.48167  -7.85636  1.000 31.14390  ? 445 HOH A O    1 
HETATM 3923 O O    . HOH C 3 .   ? 38.60202 28.60455  7.98721   1.000 33.24436  ? 446 HOH A O    1 
HETATM 3924 O O    . HOH C 3 .   ? 28.56024 2.68596   -2.53875  1.000 23.13382  ? 447 HOH A O    1 
HETATM 3925 O O    . HOH C 3 .   ? 21.40283 8.35458   4.30025   1.000 35.08718  ? 448 HOH A O    1 
HETATM 3926 O O    . HOH C 3 .   ? 20.46881 8.94699   7.91653   1.000 23.29303  ? 449 HOH A O    1 
HETATM 3927 O O    . HOH C 3 .   ? 21.22855 21.60838  -7.56516  1.000 37.23090  ? 450 HOH A O    1 
HETATM 3928 O O    . HOH C 3 .   ? 4.31391  14.59186  5.88608   1.000 37.53178  ? 451 HOH A O    1 
HETATM 3929 O O    . HOH C 3 .   ? 38.289   -4.711    14.630    1.000 37.25847  ? 452 HOH A O    1 
HETATM 3930 O O    . HOH C 3 .   ? 5.82760  13.83360  24.50322  1.000 41.82381  ? 453 HOH A O    1 
HETATM 3931 O O    . HOH C 3 .   ? 18.69874 0.05446   15.11200  1.000 34.41626  ? 454 HOH A O    1 
HETATM 3932 O O    . HOH C 3 .   ? 16.91472 11.85208  24.23586  1.000 38.82987  ? 455 HOH A O    1 
HETATM 3933 O O    . HOH C 3 .   ? 18.88587 12.79455  16.23601  1.000 22.49623  ? 456 HOH A O    1 
HETATM 3934 O O    . HOH C 3 .   ? 21.822   -0.613    -6.968    1.000 29.86418  ? 457 HOH A O    1 
HETATM 3935 O O    . HOH C 3 .   ? 2.57270  11.58029  20.73911  1.000 52.74179  ? 458 HOH A O    1 
HETATM 3936 O O    . HOH C 3 .   ? 26.76830 39.32303  1.31593   1.000 30.93419  ? 459 HOH A O    1 
HETATM 3937 O O    . HOH C 3 .   ? 40.26459 19.78865  10.30444  1.000 30.14764  ? 460 HOH A O    1 
HETATM 3938 O O    . HOH C 3 .   ? 18.41422 0.97168   18.08543  1.000 36.67295  ? 461 HOH A O    1 
HETATM 3939 O O    . HOH C 3 .   ? 25.86900 7.13506   15.01270  1.000 26.17078  ? 462 HOH A O    1 
HETATM 3940 O O    . HOH C 3 .   ? 6.586    34.077    16.418    1.000 20.61152  ? 463 HOH A O    1 
HETATM 3941 O O    . HOH C 3 .   ? 19.53850 1.72200   -1.41269  1.000 24.96886  ? 464 HOH A O    1 
HETATM 3942 O O    . HOH C 3 .   ? 27.92405 10.71141  29.18561  1.000 43.28487  ? 465 HOH A O    1 
HETATM 3943 O O    . HOH C 3 .   ? 18.64871 -2.01340  15.99604  1.000 20.37280  ? 466 HOH A O    1 
HETATM 3944 O O    . HOH C 3 .   ? 28.28059 3.65775   23.11015  1.000 32.85974  ? 467 HOH A O    1 
HETATM 3945 O O    . HOH C 3 .   ? 18.09801 1.13864   12.91701  1.000 27.52877  ? 468 HOH A O    1 
HETATM 3946 O O    . HOH C 3 .   ? 9.17695  19.61395  27.41208  1.000 23.94185  ? 469 HOH A O    1 
HETATM 3947 O O    . HOH C 3 .   ? 17.36433 2.12584   -1.79434  1.000 46.44934  ? 470 HOH A O    1 
HETATM 3948 O O    . HOH C 3 .   ? 37.05896 18.14273  19.74832  1.000 35.19371  ? 471 HOH A O    1 
HETATM 3949 O O    . HOH C 3 .   ? 18.45461 -0.42027  10.19731  1.000 42.50804  ? 472 HOH A O    1 
HETATM 3950 O O    . HOH C 3 .   ? 14.86516 11.96776  24.70631  1.000 48.06037  ? 473 HOH A O    1 
HETATM 3951 O O    . HOH C 3 .   ? 19.21680 4.15050   -1.08343  1.000 44.84182  ? 474 HOH A O    1 
HETATM 3952 O O    . HOH C 3 .   ? 23.74917 12.04227  -19.21162 1.000 27.50066  ? 475 HOH A O    1 
HETATM 3953 O O    . HOH C 3 .   ? 18.90675 8.04606   4.44952   1.000 26.53441  ? 476 HOH A O    1 
HETATM 3954 O O    . HOH C 3 .   ? 14.19901 32.18902  16.37643  1.000 46.81184  ? 477 HOH A O    1 
HETATM 3955 O O    . HOH C 3 .   ? 37.87445 9.39694   -0.73930  1.000 26.57574  ? 478 HOH A O    1 
HETATM 3956 O O    . HOH C 3 .   ? 18.40569 12.59461  26.32201  1.000 46.68634  ? 479 HOH A O    1 
HETATM 3957 O O    . HOH C 3 .   ? 17.87776 30.58320  18.19170  1.000 35.14172  ? 480 HOH A O    1 
HETATM 3958 O O    . HOH C 3 .   ? 23.95108 2.87644   -0.01824  1.000 45.88181  ? 481 HOH A O    1 
HETATM 3959 O O    . HOH C 3 .   ? 42.98121 16.13568  10.46915  1.000 35.66473  ? 482 HOH A O    1 
HETATM 3960 O O    . HOH C 3 .   ? 33.94044 7.66826   1.95469   1.000 22.20552  ? 483 HOH A O    1 
HETATM 3961 O O    . HOH C 3 .   ? 4.38940  11.79944  25.24054  1.000 40.59928  ? 484 HOH A O    1 
HETATM 3962 O O    . HOH C 3 .   ? 14.93500 3.37280   13.42617  1.000 43.33998  ? 485 HOH A O    1 
HETATM 3963 O O    . HOH C 3 .   ? 18.85048 10.38402  26.20914  1.000 42.65703  ? 486 HOH A O    1 
HETATM 3964 O O    . HOH C 3 .   ? 17.33387 -2.89687  13.93958  1.000 34.07487  ? 487 HOH A O    1 
HETATM 3965 O O    . HOH C 3 .   ? 28.77544 0.00000   32.33550  0.50  26.94400  ? 488 HOH A O    1 
HETATM 3966 O O    . HOH C 3 .   ? 15.09812 -7.01454  21.26142  1.000 33.17686  ? 489 HOH A O    1 
HETATM 3967 O O    . HOH C 3 .   ? 15.70810 -9.28242  21.31810  1.000 54.11996  ? 490 HOH A O    1 
HETATM 3968 O O    . HOH D 3 .   ? 13.80156 13.34782  -4.70848  1.000 50.01907  ? 401 HOH B O    1 
HETATM 3969 O O    . HOH D 3 .   ? 18.90043 11.10355  -1.19670  1.000 44.60633  ? 402 HOH B O    1 
HETATM 3970 O O    . HOH D 3 .   ? 20.30644 16.93452  7.56973   1.000 17.46507  ? 403 HOH B O    1 
HETATM 3971 O O    . HOH D 3 .   ? 13.43826 10.54253  19.97014  1.000 38.07869  ? 404 HOH B O    1 
HETATM 3972 O O    . HOH D 3 .   ? 20.79650 18.35944  5.13304   1.000 29.51494  ? 405 HOH B O    1 
HETATM 3973 O O    . HOH D 3 .   ? 19.96012 9.77367   3.15785   1.000 35.10759  ? 406 HOH B O    1 
HETATM 3974 O O    . HOH D 3 .   ? 14.08847 10.21085  11.64417  1.000 33.81047  ? 407 HOH B O    1 
HETATM 3975 O O    . HOH D 3 .   ? 18.17976 8.39560   6.84495   1.000 59.91865  ? 408 HOH B O    1 
HETATM 3976 O O    . HOH D 3 .   ? 10.69423 6.19789   8.64638   1.000 44.53359  ? 409 HOH B O    1 
HETATM 3977 O O    . HOH D 3 .   ? 7.74139  5.35862   9.32675   1.000 47.27183  ? 410 HOH B O    1 
HETATM 3978 O O    . HOH D 3 .   ? 5.25776  6.39314   9.59057   1.000 49.86100  ? 411 HOH B O    1 
HETATM 3979 O O    . HOH D 3 .   ? 2.82057  7.32101   10.14416  1.000 38.72580  ? 412 HOH B O    1 
HETATM 3980 O O    . HOH D 3 .   ? 10.58223 4.68062   6.59027   1.000 39.16041  ? 413 HOH B O    1 
# 
