data_9F2H
# 
_entry.id   9F2H 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.400 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9F2H         pdb_00009f2h 10.2210/pdb9f2h/pdb 
WWPDB D_1292131922 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-13 
2 'Structure model' 1 1 2024-11-27 
3 'Structure model' 1 2 2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
2 2 'Structure model' '_citation_author.identifier_ORCID' 
3 3 'Structure model' '_citation.journal_volume'          
4 3 'Structure model' '_citation.page_first'              
5 3 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9F2H 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        'Same protein, different inhibitor.' 
_pdbx_database_related.db_id          9F2G 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              xbeatriz@iqf.csic.es 
_pdbx_contact_author.name_first         Beatriz 
_pdbx_contact_author.name_last          'Gonzalez Perez' 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0710-0202 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Marquez-Monino, M.A.'   1 0000-0003-4177-9359 
'Gonzalez, B.'           2 0000-0002-0710-0202 
'Perez-Canadillas, J.M.' 3 0000-0002-8266-5502 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Structure 
_citation.journal_id_ASTM           STRUE6 
_citation.journal_id_CSD            2005 
_citation.journal_id_ISSN           0969-2126 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            33 
_citation.language                  ? 
_citation.page_first                39 
_citation.page_last                 ? 
_citation.title                     
'The ALS drug riluzole binds to the C-terminal domain of SARS-CoV-2 nucleocapsid protein and has antiviral activity.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.str.2024.10.025 
_citation.pdbx_database_id_PubMed   39541975 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Marquez-Monino, M.A.'   1 ? 
primary 'Santiveri, C.M.'        2 ? 
primary 'de Leon, P.'            3 ? 
primary 'Camero, S.'             4 ? 
primary 'Campos-Olivas, R.'      5 ? 
primary 'Jimenez, M.A.'          6 ? 
primary 'Saiz, M.'               7 ? 
primary 'Gonzalez, B.'           8 ? 
primary 'Perez-Canadillas, J.M.' 9 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Nucleoprotein                                   12528.094 4   ? ? ? 
'C-terminal domain. Initial GS are expression tags.' 
2 non-polymer nat '6-(trifluoromethoxy)-1,3-benzothiazol-2-amine' 234.198   1   ? ? ? ? 
3 non-polymer syn 'SULFATE ION'                                   96.063    3   ? ? ? ? 
4 non-polymer syn 1,2-ETHANEDIOL                                  62.068    1   ? ? ? ? 
5 water       nat water                                           18.015    626 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'N,Nucleocapsid protein,NC,Protein N' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GSKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTY
TGAIKLDDKDPNFKDQVILLNKHIDAYKTFP
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GSKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTY
TGAIKLDDKDPNFKDQVILLNKHIDAYKTFP
;
_entity_poly.pdbx_strand_id                 A,B,C,D 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '6-(trifluoromethoxy)-1,3-benzothiazol-2-amine' 657 
3 'SULFATE ION'                                   SO4 
4 1,2-ETHANEDIOL                                  EDO 
5 water                                           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   LYS n 
1 4   LYS n 
1 5   PRO n 
1 6   ARG n 
1 7   GLN n 
1 8   LYS n 
1 9   ARG n 
1 10  THR n 
1 11  ALA n 
1 12  THR n 
1 13  LYS n 
1 14  ALA n 
1 15  TYR n 
1 16  ASN n 
1 17  VAL n 
1 18  THR n 
1 19  GLN n 
1 20  ALA n 
1 21  PHE n 
1 22  GLY n 
1 23  ARG n 
1 24  ARG n 
1 25  GLY n 
1 26  PRO n 
1 27  GLU n 
1 28  GLN n 
1 29  THR n 
1 30  GLN n 
1 31  GLY n 
1 32  ASN n 
1 33  PHE n 
1 34  GLY n 
1 35  ASP n 
1 36  GLN n 
1 37  GLU n 
1 38  LEU n 
1 39  ILE n 
1 40  ARG n 
1 41  GLN n 
1 42  GLY n 
1 43  THR n 
1 44  ASP n 
1 45  TYR n 
1 46  LYS n 
1 47  HIS n 
1 48  TRP n 
1 49  PRO n 
1 50  GLN n 
1 51  ILE n 
1 52  ALA n 
1 53  GLN n 
1 54  PHE n 
1 55  ALA n 
1 56  PRO n 
1 57  SER n 
1 58  ALA n 
1 59  SER n 
1 60  ALA n 
1 61  PHE n 
1 62  PHE n 
1 63  GLY n 
1 64  MET n 
1 65  SER n 
1 66  ARG n 
1 67  ILE n 
1 68  GLY n 
1 69  MET n 
1 70  GLU n 
1 71  VAL n 
1 72  THR n 
1 73  PRO n 
1 74  SER n 
1 75  GLY n 
1 76  THR n 
1 77  TRP n 
1 78  LEU n 
1 79  THR n 
1 80  TYR n 
1 81  THR n 
1 82  GLY n 
1 83  ALA n 
1 84  ILE n 
1 85  LYS n 
1 86  LEU n 
1 87  ASP n 
1 88  ASP n 
1 89  LYS n 
1 90  ASP n 
1 91  PRO n 
1 92  ASN n 
1 93  PHE n 
1 94  LYS n 
1 95  ASP n 
1 96  GLN n 
1 97  VAL n 
1 98  ILE n 
1 99  LEU n 
1 100 LEU n 
1 101 ASN n 
1 102 LYS n 
1 103 HIS n 
1 104 ILE n 
1 105 ASP n 
1 106 ALA n 
1 107 TYR n 
1 108 LYS n 
1 109 THR n 
1 110 PHE n 
1 111 PRO n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   111 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          pET 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pET28-txAHEV 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
657 non-polymer         . '6-(trifluoromethoxy)-1,3-benzothiazol-2-amine' Riluzole          'C8 H5 F3 N2 O S' 234.198 
ALA 'L-peptide linking' y ALANINE                                         ?                 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                                        ?                 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                                      ?                 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                 ?                 'C4 H7 N O4'      133.103 
EDO non-polymer         . 1,2-ETHANEDIOL                                  'ETHYLENE GLYCOL' 'C2 H6 O2'        62.068  
GLN 'L-peptide linking' y GLUTAMINE                                       ?                 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                 ?                 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                                         ?                 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                                       ?                 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                                           ?                 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                      ?                 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                                         ?                 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                                          ?                 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                                      ?                 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                   ?                 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                                         ?                 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                                          ?                 'C3 H7 N O3'      105.093 
SO4 non-polymer         . 'SULFATE ION'                                   ?                 'O4 S -2'         96.063  
THR 'L-peptide linking' y THREONINE                                       ?                 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                      ?                 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                                        ?                 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                                          ?                 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   254 ?   ?   ?   A . n 
A 1 2   SER 2   255 ?   ?   ?   A . n 
A 1 3   LYS 3   256 ?   ?   ?   A . n 
A 1 4   LYS 4   257 257 LYS LYS A . n 
A 1 5   PRO 5   258 258 PRO PRO A . n 
A 1 6   ARG 6   259 259 ARG ARG A . n 
A 1 7   GLN 7   260 260 GLN GLN A . n 
A 1 8   LYS 8   261 261 LYS LYS A . n 
A 1 9   ARG 9   262 262 ARG ARG A . n 
A 1 10  THR 10  263 263 THR THR A . n 
A 1 11  ALA 11  264 264 ALA ALA A . n 
A 1 12  THR 12  265 265 THR THR A . n 
A 1 13  LYS 13  266 266 LYS LYS A . n 
A 1 14  ALA 14  267 267 ALA ALA A . n 
A 1 15  TYR 15  268 268 TYR TYR A . n 
A 1 16  ASN 16  269 269 ASN ASN A . n 
A 1 17  VAL 17  270 270 VAL VAL A . n 
A 1 18  THR 18  271 271 THR THR A . n 
A 1 19  GLN 19  272 272 GLN GLN A . n 
A 1 20  ALA 20  273 273 ALA ALA A . n 
A 1 21  PHE 21  274 274 PHE PHE A . n 
A 1 22  GLY 22  275 275 GLY GLY A . n 
A 1 23  ARG 23  276 276 ARG ARG A . n 
A 1 24  ARG 24  277 277 ARG ARG A . n 
A 1 25  GLY 25  278 278 GLY GLY A . n 
A 1 26  PRO 26  279 279 PRO PRO A . n 
A 1 27  GLU 27  280 280 GLU GLU A . n 
A 1 28  GLN 28  281 281 GLN GLN A . n 
A 1 29  THR 29  282 282 THR THR A . n 
A 1 30  GLN 30  283 283 GLN GLN A . n 
A 1 31  GLY 31  284 284 GLY GLY A . n 
A 1 32  ASN 32  285 285 ASN ASN A . n 
A 1 33  PHE 33  286 286 PHE PHE A . n 
A 1 34  GLY 34  287 287 GLY GLY A . n 
A 1 35  ASP 35  288 288 ASP ASP A . n 
A 1 36  GLN 36  289 289 GLN GLN A . n 
A 1 37  GLU 37  290 290 GLU GLU A . n 
A 1 38  LEU 38  291 291 LEU LEU A . n 
A 1 39  ILE 39  292 292 ILE ILE A . n 
A 1 40  ARG 40  293 293 ARG ARG A . n 
A 1 41  GLN 41  294 294 GLN GLN A . n 
A 1 42  GLY 42  295 295 GLY GLY A . n 
A 1 43  THR 43  296 296 THR THR A . n 
A 1 44  ASP 44  297 297 ASP ASP A . n 
A 1 45  TYR 45  298 298 TYR TYR A . n 
A 1 46  LYS 46  299 299 LYS LYS A . n 
A 1 47  HIS 47  300 300 HIS HIS A . n 
A 1 48  TRP 48  301 301 TRP TRP A . n 
A 1 49  PRO 49  302 302 PRO PRO A . n 
A 1 50  GLN 50  303 303 GLN GLN A . n 
A 1 51  ILE 51  304 304 ILE ILE A . n 
A 1 52  ALA 52  305 305 ALA ALA A . n 
A 1 53  GLN 53  306 306 GLN GLN A . n 
A 1 54  PHE 54  307 307 PHE PHE A . n 
A 1 55  ALA 55  308 308 ALA ALA A . n 
A 1 56  PRO 56  309 309 PRO PRO A . n 
A 1 57  SER 57  310 310 SER SER A . n 
A 1 58  ALA 58  311 311 ALA ALA A . n 
A 1 59  SER 59  312 312 SER SER A . n 
A 1 60  ALA 60  313 313 ALA ALA A . n 
A 1 61  PHE 61  314 314 PHE PHE A . n 
A 1 62  PHE 62  315 315 PHE PHE A . n 
A 1 63  GLY 63  316 316 GLY GLY A . n 
A 1 64  MET 64  317 317 MET MET A . n 
A 1 65  SER 65  318 318 SER SER A . n 
A 1 66  ARG 66  319 319 ARG ARG A . n 
A 1 67  ILE 67  320 320 ILE ILE A . n 
A 1 68  GLY 68  321 321 GLY GLY A . n 
A 1 69  MET 69  322 322 MET MET A . n 
A 1 70  GLU 70  323 323 GLU GLU A . n 
A 1 71  VAL 71  324 324 VAL VAL A . n 
A 1 72  THR 72  325 325 THR THR A . n 
A 1 73  PRO 73  326 326 PRO PRO A . n 
A 1 74  SER 74  327 327 SER SER A . n 
A 1 75  GLY 75  328 328 GLY GLY A . n 
A 1 76  THR 76  329 329 THR THR A . n 
A 1 77  TRP 77  330 330 TRP TRP A . n 
A 1 78  LEU 78  331 331 LEU LEU A . n 
A 1 79  THR 79  332 332 THR THR A . n 
A 1 80  TYR 80  333 333 TYR TYR A . n 
A 1 81  THR 81  334 334 THR THR A . n 
A 1 82  GLY 82  335 335 GLY GLY A . n 
A 1 83  ALA 83  336 336 ALA ALA A . n 
A 1 84  ILE 84  337 337 ILE ILE A . n 
A 1 85  LYS 85  338 338 LYS LYS A . n 
A 1 86  LEU 86  339 339 LEU LEU A . n 
A 1 87  ASP 87  340 340 ASP ASP A . n 
A 1 88  ASP 88  341 341 ASP ASP A . n 
A 1 89  LYS 89  342 342 LYS LYS A . n 
A 1 90  ASP 90  343 343 ASP ASP A . n 
A 1 91  PRO 91  344 344 PRO PRO A . n 
A 1 92  ASN 92  345 345 ASN ASN A . n 
A 1 93  PHE 93  346 346 PHE PHE A . n 
A 1 94  LYS 94  347 347 LYS LYS A . n 
A 1 95  ASP 95  348 348 ASP ASP A . n 
A 1 96  GLN 96  349 349 GLN GLN A . n 
A 1 97  VAL 97  350 350 VAL VAL A . n 
A 1 98  ILE 98  351 351 ILE ILE A . n 
A 1 99  LEU 99  352 352 LEU LEU A . n 
A 1 100 LEU 100 353 353 LEU LEU A . n 
A 1 101 ASN 101 354 354 ASN ASN A . n 
A 1 102 LYS 102 355 355 LYS LYS A . n 
A 1 103 HIS 103 356 356 HIS HIS A . n 
A 1 104 ILE 104 357 357 ILE ILE A . n 
A 1 105 ASP 105 358 358 ASP ASP A . n 
A 1 106 ALA 106 359 359 ALA ALA A . n 
A 1 107 TYR 107 360 360 TYR TYR A . n 
A 1 108 LYS 108 361 361 LYS LYS A . n 
A 1 109 THR 109 362 362 THR THR A . n 
A 1 110 PHE 110 363 363 PHE PHE A . n 
A 1 111 PRO 111 364 364 PRO PRO A . n 
B 1 1   GLY 1   254 ?   ?   ?   B . n 
B 1 2   SER 2   255 255 SER SER B . n 
B 1 3   LYS 3   256 256 LYS LYS B . n 
B 1 4   LYS 4   257 257 LYS LYS B . n 
B 1 5   PRO 5   258 258 PRO PRO B . n 
B 1 6   ARG 6   259 259 ARG ARG B . n 
B 1 7   GLN 7   260 260 GLN GLN B . n 
B 1 8   LYS 8   261 261 LYS LYS B . n 
B 1 9   ARG 9   262 262 ARG ARG B . n 
B 1 10  THR 10  263 263 THR THR B . n 
B 1 11  ALA 11  264 264 ALA ALA B . n 
B 1 12  THR 12  265 265 THR THR B . n 
B 1 13  LYS 13  266 266 LYS LYS B . n 
B 1 14  ALA 14  267 267 ALA ALA B . n 
B 1 15  TYR 15  268 268 TYR TYR B . n 
B 1 16  ASN 16  269 269 ASN ASN B . n 
B 1 17  VAL 17  270 270 VAL VAL B . n 
B 1 18  THR 18  271 271 THR THR B . n 
B 1 19  GLN 19  272 272 GLN GLN B . n 
B 1 20  ALA 20  273 273 ALA ALA B . n 
B 1 21  PHE 21  274 274 PHE PHE B . n 
B 1 22  GLY 22  275 275 GLY GLY B . n 
B 1 23  ARG 23  276 276 ARG ARG B . n 
B 1 24  ARG 24  277 277 ARG ARG B . n 
B 1 25  GLY 25  278 278 GLY GLY B . n 
B 1 26  PRO 26  279 279 PRO PRO B . n 
B 1 27  GLU 27  280 280 GLU GLU B . n 
B 1 28  GLN 28  281 281 GLN GLN B . n 
B 1 29  THR 29  282 282 THR THR B . n 
B 1 30  GLN 30  283 283 GLN GLN B . n 
B 1 31  GLY 31  284 284 GLY GLY B . n 
B 1 32  ASN 32  285 285 ASN ASN B . n 
B 1 33  PHE 33  286 286 PHE PHE B . n 
B 1 34  GLY 34  287 287 GLY GLY B . n 
B 1 35  ASP 35  288 288 ASP ASP B . n 
B 1 36  GLN 36  289 289 GLN GLN B . n 
B 1 37  GLU 37  290 290 GLU GLU B . n 
B 1 38  LEU 38  291 291 LEU LEU B . n 
B 1 39  ILE 39  292 292 ILE ILE B . n 
B 1 40  ARG 40  293 293 ARG ARG B . n 
B 1 41  GLN 41  294 294 GLN GLN B . n 
B 1 42  GLY 42  295 295 GLY GLY B . n 
B 1 43  THR 43  296 296 THR THR B . n 
B 1 44  ASP 44  297 297 ASP ASP B . n 
B 1 45  TYR 45  298 298 TYR TYR B . n 
B 1 46  LYS 46  299 299 LYS LYS B . n 
B 1 47  HIS 47  300 300 HIS HIS B . n 
B 1 48  TRP 48  301 301 TRP TRP B . n 
B 1 49  PRO 49  302 302 PRO PRO B . n 
B 1 50  GLN 50  303 303 GLN GLN B . n 
B 1 51  ILE 51  304 304 ILE ILE B . n 
B 1 52  ALA 52  305 305 ALA ALA B . n 
B 1 53  GLN 53  306 306 GLN GLN B . n 
B 1 54  PHE 54  307 307 PHE PHE B . n 
B 1 55  ALA 55  308 308 ALA ALA B . n 
B 1 56  PRO 56  309 309 PRO PRO B . n 
B 1 57  SER 57  310 310 SER SER B . n 
B 1 58  ALA 58  311 311 ALA ALA B . n 
B 1 59  SER 59  312 312 SER SER B . n 
B 1 60  ALA 60  313 313 ALA ALA B . n 
B 1 61  PHE 61  314 314 PHE PHE B . n 
B 1 62  PHE 62  315 315 PHE PHE B . n 
B 1 63  GLY 63  316 316 GLY GLY B . n 
B 1 64  MET 64  317 317 MET MET B . n 
B 1 65  SER 65  318 318 SER SER B . n 
B 1 66  ARG 66  319 319 ARG ARG B . n 
B 1 67  ILE 67  320 320 ILE ILE B . n 
B 1 68  GLY 68  321 321 GLY GLY B . n 
B 1 69  MET 69  322 322 MET MET B . n 
B 1 70  GLU 70  323 323 GLU GLU B . n 
B 1 71  VAL 71  324 324 VAL VAL B . n 
B 1 72  THR 72  325 325 THR THR B . n 
B 1 73  PRO 73  326 326 PRO PRO B . n 
B 1 74  SER 74  327 327 SER SER B . n 
B 1 75  GLY 75  328 328 GLY GLY B . n 
B 1 76  THR 76  329 329 THR THR B . n 
B 1 77  TRP 77  330 330 TRP TRP B . n 
B 1 78  LEU 78  331 331 LEU LEU B . n 
B 1 79  THR 79  332 332 THR THR B . n 
B 1 80  TYR 80  333 333 TYR TYR B . n 
B 1 81  THR 81  334 334 THR THR B . n 
B 1 82  GLY 82  335 335 GLY GLY B . n 
B 1 83  ALA 83  336 336 ALA ALA B . n 
B 1 84  ILE 84  337 337 ILE ILE B . n 
B 1 85  LYS 85  338 338 LYS LYS B . n 
B 1 86  LEU 86  339 339 LEU LEU B . n 
B 1 87  ASP 87  340 340 ASP ASP B . n 
B 1 88  ASP 88  341 341 ASP ASP B . n 
B 1 89  LYS 89  342 342 LYS LYS B . n 
B 1 90  ASP 90  343 343 ASP ASP B . n 
B 1 91  PRO 91  344 344 PRO PRO B . n 
B 1 92  ASN 92  345 345 ASN ASN B . n 
B 1 93  PHE 93  346 346 PHE PHE B . n 
B 1 94  LYS 94  347 347 LYS LYS B . n 
B 1 95  ASP 95  348 348 ASP ASP B . n 
B 1 96  GLN 96  349 349 GLN GLN B . n 
B 1 97  VAL 97  350 350 VAL VAL B . n 
B 1 98  ILE 98  351 351 ILE ILE B . n 
B 1 99  LEU 99  352 352 LEU LEU B . n 
B 1 100 LEU 100 353 353 LEU LEU B . n 
B 1 101 ASN 101 354 354 ASN ASN B . n 
B 1 102 LYS 102 355 355 LYS LYS B . n 
B 1 103 HIS 103 356 356 HIS HIS B . n 
B 1 104 ILE 104 357 357 ILE ILE B . n 
B 1 105 ASP 105 358 358 ASP ASP B . n 
B 1 106 ALA 106 359 359 ALA ALA B . n 
B 1 107 TYR 107 360 360 TYR TYR B . n 
B 1 108 LYS 108 361 361 LYS LYS B . n 
B 1 109 THR 109 362 362 THR THR B . n 
B 1 110 PHE 110 363 363 PHE PHE B . n 
B 1 111 PRO 111 364 364 PRO PRO B . n 
C 1 1   GLY 1   254 ?   ?   ?   C . n 
C 1 2   SER 2   255 ?   ?   ?   C . n 
C 1 3   LYS 3   256 256 LYS LYS C . n 
C 1 4   LYS 4   257 257 LYS LYS C . n 
C 1 5   PRO 5   258 258 PRO PRO C . n 
C 1 6   ARG 6   259 259 ARG ARG C . n 
C 1 7   GLN 7   260 260 GLN GLN C . n 
C 1 8   LYS 8   261 261 LYS LYS C . n 
C 1 9   ARG 9   262 262 ARG ARG C . n 
C 1 10  THR 10  263 263 THR THR C . n 
C 1 11  ALA 11  264 264 ALA ALA C . n 
C 1 12  THR 12  265 265 THR THR C . n 
C 1 13  LYS 13  266 266 LYS LYS C . n 
C 1 14  ALA 14  267 267 ALA ALA C . n 
C 1 15  TYR 15  268 268 TYR TYR C . n 
C 1 16  ASN 16  269 269 ASN ASN C . n 
C 1 17  VAL 17  270 270 VAL VAL C . n 
C 1 18  THR 18  271 271 THR THR C . n 
C 1 19  GLN 19  272 272 GLN GLN C . n 
C 1 20  ALA 20  273 273 ALA ALA C . n 
C 1 21  PHE 21  274 274 PHE PHE C . n 
C 1 22  GLY 22  275 275 GLY GLY C . n 
C 1 23  ARG 23  276 276 ARG ARG C . n 
C 1 24  ARG 24  277 277 ARG ARG C . n 
C 1 25  GLY 25  278 278 GLY GLY C . n 
C 1 26  PRO 26  279 279 PRO PRO C . n 
C 1 27  GLU 27  280 280 GLU GLU C . n 
C 1 28  GLN 28  281 281 GLN GLN C . n 
C 1 29  THR 29  282 282 THR THR C . n 
C 1 30  GLN 30  283 283 GLN GLN C . n 
C 1 31  GLY 31  284 284 GLY GLY C . n 
C 1 32  ASN 32  285 285 ASN ASN C . n 
C 1 33  PHE 33  286 286 PHE PHE C . n 
C 1 34  GLY 34  287 287 GLY GLY C . n 
C 1 35  ASP 35  288 288 ASP ASP C . n 
C 1 36  GLN 36  289 289 GLN GLN C . n 
C 1 37  GLU 37  290 290 GLU GLU C . n 
C 1 38  LEU 38  291 291 LEU LEU C . n 
C 1 39  ILE 39  292 292 ILE ILE C . n 
C 1 40  ARG 40  293 293 ARG ARG C . n 
C 1 41  GLN 41  294 294 GLN GLN C . n 
C 1 42  GLY 42  295 295 GLY GLY C . n 
C 1 43  THR 43  296 296 THR THR C . n 
C 1 44  ASP 44  297 297 ASP ASP C . n 
C 1 45  TYR 45  298 298 TYR TYR C . n 
C 1 46  LYS 46  299 299 LYS LYS C . n 
C 1 47  HIS 47  300 300 HIS HIS C . n 
C 1 48  TRP 48  301 301 TRP TRP C . n 
C 1 49  PRO 49  302 302 PRO PRO C . n 
C 1 50  GLN 50  303 303 GLN GLN C . n 
C 1 51  ILE 51  304 304 ILE ILE C . n 
C 1 52  ALA 52  305 305 ALA ALA C . n 
C 1 53  GLN 53  306 306 GLN GLN C . n 
C 1 54  PHE 54  307 307 PHE PHE C . n 
C 1 55  ALA 55  308 308 ALA ALA C . n 
C 1 56  PRO 56  309 309 PRO PRO C . n 
C 1 57  SER 57  310 310 SER SER C . n 
C 1 58  ALA 58  311 311 ALA ALA C . n 
C 1 59  SER 59  312 312 SER SER C . n 
C 1 60  ALA 60  313 313 ALA ALA C . n 
C 1 61  PHE 61  314 314 PHE PHE C . n 
C 1 62  PHE 62  315 315 PHE PHE C . n 
C 1 63  GLY 63  316 316 GLY GLY C . n 
C 1 64  MET 64  317 317 MET MET C . n 
C 1 65  SER 65  318 318 SER SER C . n 
C 1 66  ARG 66  319 319 ARG ARG C . n 
C 1 67  ILE 67  320 320 ILE ILE C . n 
C 1 68  GLY 68  321 321 GLY GLY C . n 
C 1 69  MET 69  322 322 MET MET C . n 
C 1 70  GLU 70  323 323 GLU GLU C . n 
C 1 71  VAL 71  324 324 VAL VAL C . n 
C 1 72  THR 72  325 325 THR THR C . n 
C 1 73  PRO 73  326 326 PRO PRO C . n 
C 1 74  SER 74  327 327 SER SER C . n 
C 1 75  GLY 75  328 328 GLY GLY C . n 
C 1 76  THR 76  329 329 THR THR C . n 
C 1 77  TRP 77  330 330 TRP TRP C . n 
C 1 78  LEU 78  331 331 LEU LEU C . n 
C 1 79  THR 79  332 332 THR THR C . n 
C 1 80  TYR 80  333 333 TYR TYR C . n 
C 1 81  THR 81  334 334 THR THR C . n 
C 1 82  GLY 82  335 335 GLY GLY C . n 
C 1 83  ALA 83  336 336 ALA ALA C . n 
C 1 84  ILE 84  337 337 ILE ILE C . n 
C 1 85  LYS 85  338 338 LYS LYS C . n 
C 1 86  LEU 86  339 339 LEU LEU C . n 
C 1 87  ASP 87  340 340 ASP ASP C . n 
C 1 88  ASP 88  341 341 ASP ASP C . n 
C 1 89  LYS 89  342 342 LYS LYS C . n 
C 1 90  ASP 90  343 343 ASP ASP C . n 
C 1 91  PRO 91  344 344 PRO PRO C . n 
C 1 92  ASN 92  345 345 ASN ASN C . n 
C 1 93  PHE 93  346 346 PHE PHE C . n 
C 1 94  LYS 94  347 347 LYS LYS C . n 
C 1 95  ASP 95  348 348 ASP ASP C . n 
C 1 96  GLN 96  349 349 GLN GLN C . n 
C 1 97  VAL 97  350 350 VAL VAL C . n 
C 1 98  ILE 98  351 351 ILE ILE C . n 
C 1 99  LEU 99  352 352 LEU LEU C . n 
C 1 100 LEU 100 353 353 LEU LEU C . n 
C 1 101 ASN 101 354 354 ASN ASN C . n 
C 1 102 LYS 102 355 355 LYS LYS C . n 
C 1 103 HIS 103 356 356 HIS HIS C . n 
C 1 104 ILE 104 357 357 ILE ILE C . n 
C 1 105 ASP 105 358 358 ASP ASP C . n 
C 1 106 ALA 106 359 359 ALA ALA C . n 
C 1 107 TYR 107 360 360 TYR TYR C . n 
C 1 108 LYS 108 361 361 LYS LYS C . n 
C 1 109 THR 109 362 362 THR THR C . n 
C 1 110 PHE 110 363 363 PHE PHE C . n 
C 1 111 PRO 111 364 364 PRO PRO C . n 
D 1 1   GLY 1   254 ?   ?   ?   D . n 
D 1 2   SER 2   255 ?   ?   ?   D . n 
D 1 3   LYS 3   256 ?   ?   ?   D . n 
D 1 4   LYS 4   257 257 LYS LYS D . n 
D 1 5   PRO 5   258 258 PRO PRO D . n 
D 1 6   ARG 6   259 259 ARG ARG D . n 
D 1 7   GLN 7   260 260 GLN GLN D . n 
D 1 8   LYS 8   261 261 LYS LYS D . n 
D 1 9   ARG 9   262 262 ARG ARG D . n 
D 1 10  THR 10  263 263 THR THR D . n 
D 1 11  ALA 11  264 264 ALA ALA D . n 
D 1 12  THR 12  265 265 THR THR D . n 
D 1 13  LYS 13  266 266 LYS LYS D . n 
D 1 14  ALA 14  267 267 ALA ALA D . n 
D 1 15  TYR 15  268 268 TYR TYR D . n 
D 1 16  ASN 16  269 269 ASN ASN D . n 
D 1 17  VAL 17  270 270 VAL VAL D . n 
D 1 18  THR 18  271 271 THR THR D . n 
D 1 19  GLN 19  272 272 GLN GLN D . n 
D 1 20  ALA 20  273 273 ALA ALA D . n 
D 1 21  PHE 21  274 274 PHE PHE D . n 
D 1 22  GLY 22  275 275 GLY GLY D . n 
D 1 23  ARG 23  276 276 ARG ARG D . n 
D 1 24  ARG 24  277 277 ARG ARG D . n 
D 1 25  GLY 25  278 278 GLY GLY D . n 
D 1 26  PRO 26  279 279 PRO PRO D . n 
D 1 27  GLU 27  280 280 GLU GLU D . n 
D 1 28  GLN 28  281 281 GLN GLN D . n 
D 1 29  THR 29  282 282 THR THR D . n 
D 1 30  GLN 30  283 283 GLN GLN D . n 
D 1 31  GLY 31  284 284 GLY GLY D . n 
D 1 32  ASN 32  285 285 ASN ASN D . n 
D 1 33  PHE 33  286 286 PHE PHE D . n 
D 1 34  GLY 34  287 287 GLY GLY D . n 
D 1 35  ASP 35  288 288 ASP ASP D . n 
D 1 36  GLN 36  289 289 GLN GLN D . n 
D 1 37  GLU 37  290 290 GLU GLU D . n 
D 1 38  LEU 38  291 291 LEU LEU D . n 
D 1 39  ILE 39  292 292 ILE ILE D . n 
D 1 40  ARG 40  293 293 ARG ARG D . n 
D 1 41  GLN 41  294 294 GLN GLN D . n 
D 1 42  GLY 42  295 295 GLY GLY D . n 
D 1 43  THR 43  296 296 THR THR D . n 
D 1 44  ASP 44  297 297 ASP ASP D . n 
D 1 45  TYR 45  298 298 TYR TYR D . n 
D 1 46  LYS 46  299 299 LYS LYS D . n 
D 1 47  HIS 47  300 300 HIS HIS D . n 
D 1 48  TRP 48  301 301 TRP TRP D . n 
D 1 49  PRO 49  302 302 PRO PRO D . n 
D 1 50  GLN 50  303 303 GLN GLN D . n 
D 1 51  ILE 51  304 304 ILE ILE D . n 
D 1 52  ALA 52  305 305 ALA ALA D . n 
D 1 53  GLN 53  306 306 GLN GLN D . n 
D 1 54  PHE 54  307 307 PHE PHE D . n 
D 1 55  ALA 55  308 308 ALA ALA D . n 
D 1 56  PRO 56  309 309 PRO PRO D . n 
D 1 57  SER 57  310 310 SER SER D . n 
D 1 58  ALA 58  311 311 ALA ALA D . n 
D 1 59  SER 59  312 312 SER SER D . n 
D 1 60  ALA 60  313 313 ALA ALA D . n 
D 1 61  PHE 61  314 314 PHE PHE D . n 
D 1 62  PHE 62  315 315 PHE PHE D . n 
D 1 63  GLY 63  316 316 GLY GLY D . n 
D 1 64  MET 64  317 317 MET MET D . n 
D 1 65  SER 65  318 318 SER SER D . n 
D 1 66  ARG 66  319 319 ARG ARG D . n 
D 1 67  ILE 67  320 320 ILE ILE D . n 
D 1 68  GLY 68  321 321 GLY GLY D . n 
D 1 69  MET 69  322 322 MET MET D . n 
D 1 70  GLU 70  323 323 GLU GLU D . n 
D 1 71  VAL 71  324 324 VAL VAL D . n 
D 1 72  THR 72  325 325 THR THR D . n 
D 1 73  PRO 73  326 326 PRO PRO D . n 
D 1 74  SER 74  327 327 SER SER D . n 
D 1 75  GLY 75  328 328 GLY GLY D . n 
D 1 76  THR 76  329 329 THR THR D . n 
D 1 77  TRP 77  330 330 TRP TRP D . n 
D 1 78  LEU 78  331 331 LEU LEU D . n 
D 1 79  THR 79  332 332 THR THR D . n 
D 1 80  TYR 80  333 333 TYR TYR D . n 
D 1 81  THR 81  334 334 THR THR D . n 
D 1 82  GLY 82  335 335 GLY GLY D . n 
D 1 83  ALA 83  336 336 ALA ALA D . n 
D 1 84  ILE 84  337 337 ILE ILE D . n 
D 1 85  LYS 85  338 338 LYS LYS D . n 
D 1 86  LEU 86  339 339 LEU LEU D . n 
D 1 87  ASP 87  340 340 ASP ASP D . n 
D 1 88  ASP 88  341 341 ASP ASP D . n 
D 1 89  LYS 89  342 342 LYS LYS D . n 
D 1 90  ASP 90  343 343 ASP ASP D . n 
D 1 91  PRO 91  344 344 PRO PRO D . n 
D 1 92  ASN 92  345 345 ASN ASN D . n 
D 1 93  PHE 93  346 346 PHE PHE D . n 
D 1 94  LYS 94  347 347 LYS LYS D . n 
D 1 95  ASP 95  348 348 ASP ASP D . n 
D 1 96  GLN 96  349 349 GLN GLN D . n 
D 1 97  VAL 97  350 350 VAL VAL D . n 
D 1 98  ILE 98  351 351 ILE ILE D . n 
D 1 99  LEU 99  352 352 LEU LEU D . n 
D 1 100 LEU 100 353 353 LEU LEU D . n 
D 1 101 ASN 101 354 354 ASN ASN D . n 
D 1 102 LYS 102 355 355 LYS LYS D . n 
D 1 103 HIS 103 356 356 HIS HIS D . n 
D 1 104 ILE 104 357 357 ILE ILE D . n 
D 1 105 ASP 105 358 358 ASP ASP D . n 
D 1 106 ALA 106 359 359 ALA ALA D . n 
D 1 107 TYR 107 360 360 TYR TYR D . n 
D 1 108 LYS 108 361 361 LYS LYS D . n 
D 1 109 THR 109 362 362 THR THR D . n 
D 1 110 PHE 110 363 363 PHE PHE D . n 
D 1 111 PRO 111 364 364 PRO PRO D . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        657 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   657 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 2 657 1   401 1   657 657 A . 
F 3 SO4 1   402 101 SO4 SO4 A . 
G 3 SO4 1   401 201 SO4 SO4 B . 
H 4 EDO 1   401 401 EDO EDO C . 
I 3 SO4 1   401 301 SO4 SO4 D . 
J 5 HOH 1   501 531 HOH HOH A . 
J 5 HOH 2   502 542 HOH HOH A . 
J 5 HOH 3   503 265 HOH HOH A . 
J 5 HOH 4   504 622 HOH HOH A . 
J 5 HOH 5   505 183 HOH HOH A . 
J 5 HOH 6   506 588 HOH HOH A . 
J 5 HOH 7   507 166 HOH HOH A . 
J 5 HOH 8   508 532 HOH HOH A . 
J 5 HOH 9   509 414 HOH HOH A . 
J 5 HOH 10  510 366 HOH HOH A . 
J 5 HOH 11  511 415 HOH HOH A . 
J 5 HOH 12  512 653 HOH HOH A . 
J 5 HOH 13  513 673 HOH HOH A . 
J 5 HOH 14  514 631 HOH HOH A . 
J 5 HOH 15  515 436 HOH HOH A . 
J 5 HOH 16  516 78  HOH HOH A . 
J 5 HOH 17  517 58  HOH HOH A . 
J 5 HOH 18  518 106 HOH HOH A . 
J 5 HOH 19  519 334 HOH HOH A . 
J 5 HOH 20  520 552 HOH HOH A . 
J 5 HOH 21  521 524 HOH HOH A . 
J 5 HOH 22  522 344 HOH HOH A . 
J 5 HOH 23  523 674 HOH HOH A . 
J 5 HOH 24  524 332 HOH HOH A . 
J 5 HOH 25  525 153 HOH HOH A . 
J 5 HOH 26  526 327 HOH HOH A . 
J 5 HOH 27  527 360 HOH HOH A . 
J 5 HOH 28  528 287 HOH HOH A . 
J 5 HOH 29  529 247 HOH HOH A . 
J 5 HOH 30  530 274 HOH HOH A . 
J 5 HOH 31  531 165 HOH HOH A . 
J 5 HOH 32  532 288 HOH HOH A . 
J 5 HOH 33  533 668 HOH HOH A . 
J 5 HOH 34  534 86  HOH HOH A . 
J 5 HOH 35  535 10  HOH HOH A . 
J 5 HOH 36  536 403 HOH HOH A . 
J 5 HOH 37  537 513 HOH HOH A . 
J 5 HOH 38  538 411 HOH HOH A . 
J 5 HOH 39  539 87  HOH HOH A . 
J 5 HOH 40  540 617 HOH HOH A . 
J 5 HOH 41  541 363 HOH HOH A . 
J 5 HOH 42  542 97  HOH HOH A . 
J 5 HOH 43  543 28  HOH HOH A . 
J 5 HOH 44  544 103 HOH HOH A . 
J 5 HOH 45  545 109 HOH HOH A . 
J 5 HOH 46  546 77  HOH HOH A . 
J 5 HOH 47  547 671 HOH HOH A . 
J 5 HOH 48  548 279 HOH HOH A . 
J 5 HOH 49  549 246 HOH HOH A . 
J 5 HOH 50  550 163 HOH HOH A . 
J 5 HOH 51  551 34  HOH HOH A . 
J 5 HOH 52  552 98  HOH HOH A . 
J 5 HOH 53  553 8   HOH HOH A . 
J 5 HOH 54  554 243 HOH HOH A . 
J 5 HOH 55  555 313 HOH HOH A . 
J 5 HOH 56  556 192 HOH HOH A . 
J 5 HOH 57  557 3   HOH HOH A . 
J 5 HOH 58  558 369 HOH HOH A . 
J 5 HOH 59  559 655 HOH HOH A . 
J 5 HOH 60  560 509 HOH HOH A . 
J 5 HOH 61  561 624 HOH HOH A . 
J 5 HOH 62  562 627 HOH HOH A . 
J 5 HOH 63  563 590 HOH HOH A . 
J 5 HOH 64  564 252 HOH HOH A . 
J 5 HOH 65  565 154 HOH HOH A . 
J 5 HOH 66  566 213 HOH HOH A . 
J 5 HOH 67  567 628 HOH HOH A . 
J 5 HOH 68  568 35  HOH HOH A . 
J 5 HOH 69  569 228 HOH HOH A . 
J 5 HOH 70  570 180 HOH HOH A . 
J 5 HOH 71  571 234 HOH HOH A . 
J 5 HOH 72  572 261 HOH HOH A . 
J 5 HOH 73  573 342 HOH HOH A . 
J 5 HOH 74  574 108 HOH HOH A . 
J 5 HOH 75  575 210 HOH HOH A . 
J 5 HOH 76  576 52  HOH HOH A . 
J 5 HOH 77  577 347 HOH HOH A . 
J 5 HOH 78  578 233 HOH HOH A . 
J 5 HOH 79  579 112 HOH HOH A . 
J 5 HOH 80  580 54  HOH HOH A . 
J 5 HOH 81  581 193 HOH HOH A . 
J 5 HOH 82  582 244 HOH HOH A . 
J 5 HOH 83  583 43  HOH HOH A . 
J 5 HOH 84  584 4   HOH HOH A . 
J 5 HOH 85  585 171 HOH HOH A . 
J 5 HOH 86  586 81  HOH HOH A . 
J 5 HOH 87  587 260 HOH HOH A . 
J 5 HOH 88  588 529 HOH HOH A . 
J 5 HOH 89  589 141 HOH HOH A . 
J 5 HOH 90  590 129 HOH HOH A . 
J 5 HOH 91  591 314 HOH HOH A . 
J 5 HOH 92  592 263 HOH HOH A . 
J 5 HOH 93  593 405 HOH HOH A . 
J 5 HOH 94  594 268 HOH HOH A . 
J 5 HOH 95  595 71  HOH HOH A . 
J 5 HOH 96  596 250 HOH HOH A . 
J 5 HOH 97  597 301 HOH HOH A . 
J 5 HOH 98  598 257 HOH HOH A . 
J 5 HOH 99  599 296 HOH HOH A . 
J 5 HOH 100 600 205 HOH HOH A . 
J 5 HOH 101 601 237 HOH HOH A . 
J 5 HOH 102 602 315 HOH HOH A . 
J 5 HOH 103 603 697 HOH HOH A . 
J 5 HOH 104 604 212 HOH HOH A . 
J 5 HOH 105 605 523 HOH HOH A . 
J 5 HOH 106 606 669 HOH HOH A . 
J 5 HOH 107 607 251 HOH HOH A . 
J 5 HOH 108 608 623 HOH HOH A . 
J 5 HOH 109 609 376 HOH HOH A . 
J 5 HOH 110 610 162 HOH HOH A . 
J 5 HOH 111 611 418 HOH HOH A . 
J 5 HOH 112 612 248 HOH HOH A . 
J 5 HOH 113 613 565 HOH HOH A . 
J 5 HOH 114 614 537 HOH HOH A . 
J 5 HOH 115 615 404 HOH HOH A . 
J 5 HOH 116 616 195 HOH HOH A . 
J 5 HOH 117 617 355 HOH HOH A . 
J 5 HOH 118 618 472 HOH HOH A . 
J 5 HOH 119 619 345 HOH HOH A . 
J 5 HOH 120 620 200 HOH HOH A . 
J 5 HOH 121 621 555 HOH HOH A . 
J 5 HOH 122 622 270 HOH HOH A . 
J 5 HOH 123 623 579 HOH HOH A . 
J 5 HOH 124 624 603 HOH HOH A . 
J 5 HOH 125 625 630 HOH HOH A . 
J 5 HOH 126 626 353 HOH HOH A . 
J 5 HOH 127 627 561 HOH HOH A . 
J 5 HOH 128 628 560 HOH HOH A . 
J 5 HOH 129 629 629 HOH HOH A . 
J 5 HOH 130 630 625 HOH HOH A . 
J 5 HOH 131 631 559 HOH HOH A . 
J 5 HOH 132 632 522 HOH HOH A . 
J 5 HOH 133 633 417 HOH HOH A . 
J 5 HOH 134 634 185 HOH HOH A . 
J 5 HOH 135 635 667 HOH HOH A . 
J 5 HOH 136 636 387 HOH HOH A . 
J 5 HOH 137 637 556 HOH HOH A . 
J 5 HOH 138 638 557 HOH HOH A . 
J 5 HOH 139 639 618 HOH HOH A . 
J 5 HOH 140 640 292 HOH HOH A . 
J 5 HOH 141 641 563 HOH HOH A . 
J 5 HOH 142 642 620 HOH HOH A . 
J 5 HOH 143 643 619 HOH HOH A . 
K 5 HOH 1   501 425 HOH HOH B . 
K 5 HOH 2   502 125 HOH HOH B . 
K 5 HOH 3   503 553 HOH HOH B . 
K 5 HOH 4   504 569 HOH HOH B . 
K 5 HOH 5   505 96  HOH HOH B . 
K 5 HOH 6   506 203 HOH HOH B . 
K 5 HOH 7   507 222 HOH HOH B . 
K 5 HOH 8   508 175 HOH HOH B . 
K 5 HOH 9   509 329 HOH HOH B . 
K 5 HOH 10  510 659 HOH HOH B . 
K 5 HOH 11  511 519 HOH HOH B . 
K 5 HOH 12  512 303 HOH HOH B . 
K 5 HOH 13  513 187 HOH HOH B . 
K 5 HOH 14  514 300 HOH HOH B . 
K 5 HOH 15  515 69  HOH HOH B . 
K 5 HOH 16  516 573 HOH HOH B . 
K 5 HOH 17  517 350 HOH HOH B . 
K 5 HOH 18  518 331 HOH HOH B . 
K 5 HOH 19  519 230 HOH HOH B . 
K 5 HOH 20  520 100 HOH HOH B . 
K 5 HOH 21  521 21  HOH HOH B . 
K 5 HOH 22  522 197 HOH HOH B . 
K 5 HOH 23  523 117 HOH HOH B . 
K 5 HOH 24  524 423 HOH HOH B . 
K 5 HOH 25  525 201 HOH HOH B . 
K 5 HOH 26  526 12  HOH HOH B . 
K 5 HOH 27  527 199 HOH HOH B . 
K 5 HOH 28  528 538 HOH HOH B . 
K 5 HOH 29  529 168 HOH HOH B . 
K 5 HOH 30  530 142 HOH HOH B . 
K 5 HOH 31  531 293 HOH HOH B . 
K 5 HOH 32  532 1   HOH HOH B . 
K 5 HOH 33  533 304 HOH HOH B . 
K 5 HOH 34  534 17  HOH HOH B . 
K 5 HOH 35  535 225 HOH HOH B . 
K 5 HOH 36  536 253 HOH HOH B . 
K 5 HOH 37  537 255 HOH HOH B . 
K 5 HOH 38  538 299 HOH HOH B . 
K 5 HOH 39  539 74  HOH HOH B . 
K 5 HOH 40  540 362 HOH HOH B . 
K 5 HOH 41  541 190 HOH HOH B . 
K 5 HOH 42  542 606 HOH HOH B . 
K 5 HOH 43  543 356 HOH HOH B . 
K 5 HOH 44  544 349 HOH HOH B . 
K 5 HOH 45  545 389 HOH HOH B . 
K 5 HOH 46  546 310 HOH HOH B . 
K 5 HOH 47  547 204 HOH HOH B . 
K 5 HOH 48  548 121 HOH HOH B . 
K 5 HOH 49  549 40  HOH HOH B . 
K 5 HOH 50  550 131 HOH HOH B . 
K 5 HOH 51  551 434 HOH HOH B . 
K 5 HOH 52  552 426 HOH HOH B . 
K 5 HOH 53  553 39  HOH HOH B . 
K 5 HOH 54  554 382 HOH HOH B . 
K 5 HOH 55  555 99  HOH HOH B . 
K 5 HOH 56  556 116 HOH HOH B . 
K 5 HOH 57  557 323 HOH HOH B . 
K 5 HOH 58  558 159 HOH HOH B . 
K 5 HOH 59  559 536 HOH HOH B . 
K 5 HOH 60  560 16  HOH HOH B . 
K 5 HOH 61  561 22  HOH HOH B . 
K 5 HOH 62  562 102 HOH HOH B . 
K 5 HOH 63  563 384 HOH HOH B . 
K 5 HOH 64  564 245 HOH HOH B . 
K 5 HOH 65  565 169 HOH HOH B . 
K 5 HOH 66  566 381 HOH HOH B . 
K 5 HOH 67  567 123 HOH HOH B . 
K 5 HOH 68  568 33  HOH HOH B . 
K 5 HOH 69  569 196 HOH HOH B . 
K 5 HOH 70  570 607 HOH HOH B . 
K 5 HOH 71  571 44  HOH HOH B . 
K 5 HOH 72  572 144 HOH HOH B . 
K 5 HOH 73  573 568 HOH HOH B . 
K 5 HOH 74  574 91  HOH HOH B . 
K 5 HOH 75  575 155 HOH HOH B . 
K 5 HOH 76  576 572 HOH HOH B . 
K 5 HOH 77  577 57  HOH HOH B . 
K 5 HOH 78  578 338 HOH HOH B . 
K 5 HOH 79  579 320 HOH HOH B . 
K 5 HOH 80  580 518 HOH HOH B . 
K 5 HOH 81  581 119 HOH HOH B . 
K 5 HOH 82  582 272 HOH HOH B . 
K 5 HOH 83  583 219 HOH HOH B . 
K 5 HOH 84  584 390 HOH HOH B . 
K 5 HOH 85  585 101 HOH HOH B . 
K 5 HOH 86  586 41  HOH HOH B . 
K 5 HOH 87  587 357 HOH HOH B . 
K 5 HOH 88  588 83  HOH HOH B . 
K 5 HOH 89  589 510 HOH HOH B . 
K 5 HOH 90  590 517 HOH HOH B . 
K 5 HOH 91  591 64  HOH HOH B . 
K 5 HOH 92  592 90  HOH HOH B . 
K 5 HOH 93  593 110 HOH HOH B . 
K 5 HOH 94  594 24  HOH HOH B . 
K 5 HOH 95  595 551 HOH HOH B . 
K 5 HOH 96  596 158 HOH HOH B . 
K 5 HOH 97  597 227 HOH HOH B . 
K 5 HOH 98  598 271 HOH HOH B . 
K 5 HOH 99  599 254 HOH HOH B . 
K 5 HOH 100 600 341 HOH HOH B . 
K 5 HOH 101 601 675 HOH HOH B . 
K 5 HOH 102 602 135 HOH HOH B . 
K 5 HOH 103 603 211 HOH HOH B . 
K 5 HOH 104 604 221 HOH HOH B . 
K 5 HOH 105 605 340 HOH HOH B . 
K 5 HOH 106 606 318 HOH HOH B . 
K 5 HOH 107 607 507 HOH HOH B . 
K 5 HOH 108 608 512 HOH HOH B . 
K 5 HOH 109 609 311 HOH HOH B . 
K 5 HOH 110 610 388 HOH HOH B . 
K 5 HOH 111 611 438 HOH HOH B . 
K 5 HOH 112 612 273 HOH HOH B . 
K 5 HOH 113 613 658 HOH HOH B . 
K 5 HOH 114 614 676 HOH HOH B . 
K 5 HOH 115 615 562 HOH HOH B . 
K 5 HOH 116 616 540 HOH HOH B . 
K 5 HOH 117 617 437 HOH HOH B . 
K 5 HOH 118 618 386 HOH HOH B . 
K 5 HOH 119 619 611 HOH HOH B . 
K 5 HOH 120 620 278 HOH HOH B . 
K 5 HOH 121 621 373 HOH HOH B . 
K 5 HOH 122 622 550 HOH HOH B . 
K 5 HOH 123 623 264 HOH HOH B . 
K 5 HOH 124 624 495 HOH HOH B . 
K 5 HOH 125 625 231 HOH HOH B . 
K 5 HOH 126 626 134 HOH HOH B . 
K 5 HOH 127 627 604 HOH HOH B . 
K 5 HOH 128 628 249 HOH HOH B . 
K 5 HOH 129 629 515 HOH HOH B . 
K 5 HOH 130 630 143 HOH HOH B . 
K 5 HOH 131 631 375 HOH HOH B . 
K 5 HOH 132 632 281 HOH HOH B . 
K 5 HOH 133 633 368 HOH HOH B . 
K 5 HOH 134 634 605 HOH HOH B . 
K 5 HOH 135 635 511 HOH HOH B . 
K 5 HOH 136 636 242 HOH HOH B . 
K 5 HOH 137 637 645 HOH HOH B . 
K 5 HOH 138 638 575 HOH HOH B . 
K 5 HOH 139 639 558 HOH HOH B . 
K 5 HOH 140 640 259 HOH HOH B . 
K 5 HOH 141 641 601 HOH HOH B . 
K 5 HOH 142 642 525 HOH HOH B . 
K 5 HOH 143 643 516 HOH HOH B . 
K 5 HOH 144 644 508 HOH HOH B . 
K 5 HOH 145 645 503 HOH HOH B . 
K 5 HOH 146 646 539 HOH HOH B . 
K 5 HOH 147 647 612 HOH HOH B . 
K 5 HOH 148 648 554 HOH HOH B . 
K 5 HOH 149 649 600 HOH HOH B . 
K 5 HOH 150 650 460 HOH HOH B . 
K 5 HOH 151 651 541 HOH HOH B . 
K 5 HOH 152 652 666 HOH HOH B . 
K 5 HOH 153 653 614 HOH HOH B . 
K 5 HOH 154 654 567 HOH HOH B . 
K 5 HOH 155 655 520 HOH HOH B . 
K 5 HOH 156 656 383 HOH HOH B . 
K 5 HOH 157 657 564 HOH HOH B . 
K 5 HOH 158 658 391 HOH HOH B . 
K 5 HOH 159 659 602 HOH HOH B . 
K 5 HOH 160 660 534 HOH HOH B . 
K 5 HOH 161 661 371 HOH HOH B . 
K 5 HOH 162 662 367 HOH HOH B . 
K 5 HOH 163 663 609 HOH HOH B . 
K 5 HOH 164 664 283 HOH HOH B . 
K 5 HOH 165 665 521 HOH HOH B . 
L 5 HOH 1   501 682 HOH HOH C . 
L 5 HOH 2   502 535 HOH HOH C . 
L 5 HOH 3   503 194 HOH HOH C . 
L 5 HOH 4   504 276 HOH HOH C . 
L 5 HOH 5   505 267 HOH HOH C . 
L 5 HOH 6   506 321 HOH HOH C . 
L 5 HOH 7   507 297 HOH HOH C . 
L 5 HOH 8   508 132 HOH HOH C . 
L 5 HOH 9   509 370 HOH HOH C . 
L 5 HOH 10  510 170 HOH HOH C . 
L 5 HOH 11  511 152 HOH HOH C . 
L 5 HOH 12  512 428 HOH HOH C . 
L 5 HOH 13  513 126 HOH HOH C . 
L 5 HOH 14  514 641 HOH HOH C . 
L 5 HOH 15  515 586 HOH HOH C . 
L 5 HOH 16  516 660 HOH HOH C . 
L 5 HOH 17  517 285 HOH HOH C . 
L 5 HOH 18  518 696 HOH HOH C . 
L 5 HOH 19  519 88  HOH HOH C . 
L 5 HOH 20  520 60  HOH HOH C . 
L 5 HOH 21  521 543 HOH HOH C . 
L 5 HOH 22  522 473 HOH HOH C . 
L 5 HOH 23  523 63  HOH HOH C . 
L 5 HOH 24  524 59  HOH HOH C . 
L 5 HOH 25  525 424 HOH HOH C . 
L 5 HOH 26  526 53  HOH HOH C . 
L 5 HOH 27  527 137 HOH HOH C . 
L 5 HOH 28  528 30  HOH HOH C . 
L 5 HOH 29  529 691 HOH HOH C . 
L 5 HOH 30  530 506 HOH HOH C . 
L 5 HOH 31  531 14  HOH HOH C . 
L 5 HOH 32  532 92  HOH HOH C . 
L 5 HOH 33  533 130 HOH HOH C . 
L 5 HOH 34  534 412 HOH HOH C . 
L 5 HOH 35  535 451 HOH HOH C . 
L 5 HOH 36  536 47  HOH HOH C . 
L 5 HOH 37  537 11  HOH HOH C . 
L 5 HOH 38  538 15  HOH HOH C . 
L 5 HOH 39  539 113 HOH HOH C . 
L 5 HOH 40  540 160 HOH HOH C . 
L 5 HOH 41  541 665 HOH HOH C . 
L 5 HOH 42  542 477 HOH HOH C . 
L 5 HOH 43  543 492 HOH HOH C . 
L 5 HOH 44  544 124 HOH HOH C . 
L 5 HOH 45  545 46  HOH HOH C . 
L 5 HOH 46  546 186 HOH HOH C . 
L 5 HOH 47  547 308 HOH HOH C . 
L 5 HOH 48  548 176 HOH HOH C . 
L 5 HOH 49  549 172 HOH HOH C . 
L 5 HOH 50  550 380 HOH HOH C . 
L 5 HOH 51  551 374 HOH HOH C . 
L 5 HOH 52  552 32  HOH HOH C . 
L 5 HOH 53  553 400 HOH HOH C . 
L 5 HOH 54  554 66  HOH HOH C . 
L 5 HOH 55  555 690 HOH HOH C . 
L 5 HOH 56  556 413 HOH HOH C . 
L 5 HOH 57  557 70  HOH HOH C . 
L 5 HOH 58  558 214 HOH HOH C . 
L 5 HOH 59  559 107 HOH HOH C . 
L 5 HOH 60  560 25  HOH HOH C . 
L 5 HOH 61  561 218 HOH HOH C . 
L 5 HOH 62  562 2   HOH HOH C . 
L 5 HOH 63  563 75  HOH HOH C . 
L 5 HOH 64  564 189 HOH HOH C . 
L 5 HOH 65  565 161 HOH HOH C . 
L 5 HOH 66  566 45  HOH HOH C . 
L 5 HOH 67  567 335 HOH HOH C . 
L 5 HOH 68  568 235 HOH HOH C . 
L 5 HOH 69  569 379 HOH HOH C . 
L 5 HOH 70  570 114 HOH HOH C . 
L 5 HOH 71  571 139 HOH HOH C . 
L 5 HOH 72  572 51  HOH HOH C . 
L 5 HOH 73  573 530 HOH HOH C . 
L 5 HOH 74  574 20  HOH HOH C . 
L 5 HOH 75  575 50  HOH HOH C . 
L 5 HOH 76  576 698 HOH HOH C . 
L 5 HOH 77  577 79  HOH HOH C . 
L 5 HOH 78  578 38  HOH HOH C . 
L 5 HOH 79  579 399 HOH HOH C . 
L 5 HOH 80  580 105 HOH HOH C . 
L 5 HOH 81  581 419 HOH HOH C . 
L 5 HOH 82  582 679 HOH HOH C . 
L 5 HOH 83  583 240 HOH HOH C . 
L 5 HOH 84  584 73  HOH HOH C . 
L 5 HOH 85  585 156 HOH HOH C . 
L 5 HOH 86  586 182 HOH HOH C . 
L 5 HOH 87  587 494 HOH HOH C . 
L 5 HOH 88  588 680 HOH HOH C . 
L 5 HOH 89  589 580 HOH HOH C . 
L 5 HOH 90  590 266 HOH HOH C . 
L 5 HOH 91  591 277 HOH HOH C . 
L 5 HOH 92  592 115 HOH HOH C . 
L 5 HOH 93  593 322 HOH HOH C . 
L 5 HOH 94  594 449 HOH HOH C . 
L 5 HOH 95  595 351 HOH HOH C . 
L 5 HOH 96  596 526 HOH HOH C . 
L 5 HOH 97  597 298 HOH HOH C . 
L 5 HOH 98  598 215 HOH HOH C . 
L 5 HOH 99  599 681 HOH HOH C . 
L 5 HOH 100 600 306 HOH HOH C . 
L 5 HOH 101 601 151 HOH HOH C . 
L 5 HOH 102 602 476 HOH HOH C . 
L 5 HOH 103 603 333 HOH HOH C . 
L 5 HOH 104 604 544 HOH HOH C . 
L 5 HOH 105 605 616 HOH HOH C . 
L 5 HOH 106 606 316 HOH HOH C . 
L 5 HOH 107 607 615 HOH HOH C . 
L 5 HOH 108 608 487 HOH HOH C . 
L 5 HOH 109 609 407 HOH HOH C . 
L 5 HOH 110 610 593 HOH HOH C . 
L 5 HOH 111 611 662 HOH HOH C . 
L 5 HOH 112 612 695 HOH HOH C . 
L 5 HOH 113 613 505 HOH HOH C . 
L 5 HOH 114 614 136 HOH HOH C . 
L 5 HOH 115 615 597 HOH HOH C . 
L 5 HOH 116 616 485 HOH HOH C . 
L 5 HOH 117 617 147 HOH HOH C . 
L 5 HOH 118 618 140 HOH HOH C . 
L 5 HOH 119 619 312 HOH HOH C . 
L 5 HOH 120 620 502 HOH HOH C . 
L 5 HOH 121 621 584 HOH HOH C . 
L 5 HOH 122 622 365 HOH HOH C . 
L 5 HOH 123 623 173 HOH HOH C . 
L 5 HOH 124 624 474 HOH HOH C . 
L 5 HOH 125 625 416 HOH HOH C . 
L 5 HOH 126 626 693 HOH HOH C . 
L 5 HOH 127 627 504 HOH HOH C . 
L 5 HOH 128 628 493 HOH HOH C . 
L 5 HOH 129 629 346 HOH HOH C . 
L 5 HOH 130 630 481 HOH HOH C . 
L 5 HOH 131 631 478 HOH HOH C . 
L 5 HOH 132 632 295 HOH HOH C . 
L 5 HOH 133 633 652 HOH HOH C . 
L 5 HOH 134 634 146 HOH HOH C . 
L 5 HOH 135 635 475 HOH HOH C . 
L 5 HOH 136 636 181 HOH HOH C . 
L 5 HOH 137 637 420 HOH HOH C . 
L 5 HOH 138 638 595 HOH HOH C . 
L 5 HOH 139 639 406 HOH HOH C . 
L 5 HOH 140 640 583 HOH HOH C . 
L 5 HOH 141 641 678 HOH HOH C . 
L 5 HOH 142 642 533 HOH HOH C . 
L 5 HOH 143 643 483 HOH HOH C . 
L 5 HOH 144 644 596 HOH HOH C . 
L 5 HOH 145 645 479 HOH HOH C . 
L 5 HOH 146 646 499 HOH HOH C . 
L 5 HOH 147 647 643 HOH HOH C . 
M 5 HOH 1   501 223 HOH HOH D . 
M 5 HOH 2   502 395 HOH HOH D . 
M 5 HOH 3   503 392 HOH HOH D . 
M 5 HOH 4   504 358 HOH HOH D . 
M 5 HOH 5   505 164 HOH HOH D . 
M 5 HOH 6   506 157 HOH HOH D . 
M 5 HOH 7   507 398 HOH HOH D . 
M 5 HOH 8   508 85  HOH HOH D . 
M 5 HOH 9   509 72  HOH HOH D . 
M 5 HOH 10  510 111 HOH HOH D . 
M 5 HOH 11  511 307 HOH HOH D . 
M 5 HOH 12  512 463 HOH HOH D . 
M 5 HOH 13  513 466 HOH HOH D . 
M 5 HOH 14  514 209 HOH HOH D . 
M 5 HOH 15  515 239 HOH HOH D . 
M 5 HOH 16  516 343 HOH HOH D . 
M 5 HOH 17  517 280 HOH HOH D . 
M 5 HOH 18  518 647 HOH HOH D . 
M 5 HOH 19  519 104 HOH HOH D . 
M 5 HOH 20  520 348 HOH HOH D . 
M 5 HOH 21  521 440 HOH HOH D . 
M 5 HOH 22  522 150 HOH HOH D . 
M 5 HOH 23  523 456 HOH HOH D . 
M 5 HOH 24  524 82  HOH HOH D . 
M 5 HOH 25  525 339 HOH HOH D . 
M 5 HOH 26  526 6   HOH HOH D . 
M 5 HOH 27  527 122 HOH HOH D . 
M 5 HOH 28  528 430 HOH HOH D . 
M 5 HOH 29  529 258 HOH HOH D . 
M 5 HOH 30  530 236 HOH HOH D . 
M 5 HOH 31  531 26  HOH HOH D . 
M 5 HOH 32  532 202 HOH HOH D . 
M 5 HOH 33  533 120 HOH HOH D . 
M 5 HOH 34  534 352 HOH HOH D . 
M 5 HOH 35  535 5   HOH HOH D . 
M 5 HOH 36  536 229 HOH HOH D . 
M 5 HOH 37  537 36  HOH HOH D . 
M 5 HOH 38  538 174 HOH HOH D . 
M 5 HOH 39  539 177 HOH HOH D . 
M 5 HOH 40  540 19  HOH HOH D . 
M 5 HOH 41  541 67  HOH HOH D . 
M 5 HOH 42  542 305 HOH HOH D . 
M 5 HOH 43  543 269 HOH HOH D . 
M 5 HOH 44  544 37  HOH HOH D . 
M 5 HOH 45  545 220 HOH HOH D . 
M 5 HOH 46  546 62  HOH HOH D . 
M 5 HOH 47  547 9   HOH HOH D . 
M 5 HOH 48  548 31  HOH HOH D . 
M 5 HOH 49  549 178 HOH HOH D . 
M 5 HOH 50  550 578 HOH HOH D . 
M 5 HOH 51  551 18  HOH HOH D . 
M 5 HOH 52  552 7   HOH HOH D . 
M 5 HOH 53  553 94  HOH HOH D . 
M 5 HOH 54  554 93  HOH HOH D . 
M 5 HOH 55  555 188 HOH HOH D . 
M 5 HOH 56  556 241 HOH HOH D . 
M 5 HOH 57  557 224 HOH HOH D . 
M 5 HOH 58  558 640 HOH HOH D . 
M 5 HOH 59  559 65  HOH HOH D . 
M 5 HOH 60  560 226 HOH HOH D . 
M 5 HOH 61  561 394 HOH HOH D . 
M 5 HOH 62  562 325 HOH HOH D . 
M 5 HOH 63  563 685 HOH HOH D . 
M 5 HOH 64  564 448 HOH HOH D . 
M 5 HOH 65  565 336 HOH HOH D . 
M 5 HOH 66  566 145 HOH HOH D . 
M 5 HOH 67  567 55  HOH HOH D . 
M 5 HOH 68  568 198 HOH HOH D . 
M 5 HOH 69  569 429 HOH HOH D . 
M 5 HOH 70  570 127 HOH HOH D . 
M 5 HOH 71  571 291 HOH HOH D . 
M 5 HOH 72  572 133 HOH HOH D . 
M 5 HOH 73  573 23  HOH HOH D . 
M 5 HOH 74  574 442 HOH HOH D . 
M 5 HOH 75  575 84  HOH HOH D . 
M 5 HOH 76  576 546 HOH HOH D . 
M 5 HOH 77  577 262 HOH HOH D . 
M 5 HOH 78  578 89  HOH HOH D . 
M 5 HOH 79  579 328 HOH HOH D . 
M 5 HOH 80  580 547 HOH HOH D . 
M 5 HOH 81  581 27  HOH HOH D . 
M 5 HOH 82  582 410 HOH HOH D . 
M 5 HOH 83  583 13  HOH HOH D . 
M 5 HOH 84  584 359 HOH HOH D . 
M 5 HOH 85  585 42  HOH HOH D . 
M 5 HOH 86  586 148 HOH HOH D . 
M 5 HOH 87  587 80  HOH HOH D . 
M 5 HOH 88  588 700 HOH HOH D . 
M 5 HOH 89  589 56  HOH HOH D . 
M 5 HOH 90  590 232 HOH HOH D . 
M 5 HOH 91  591 29  HOH HOH D . 
M 5 HOH 92  592 216 HOH HOH D . 
M 5 HOH 93  593 179 HOH HOH D . 
M 5 HOH 94  594 654 HOH HOH D . 
M 5 HOH 95  595 48  HOH HOH D . 
M 5 HOH 96  596 95  HOH HOH D . 
M 5 HOH 97  597 639 HOH HOH D . 
M 5 HOH 98  598 694 HOH HOH D . 
M 5 HOH 99  599 648 HOH HOH D . 
M 5 HOH 100 600 468 HOH HOH D . 
M 5 HOH 101 601 354 HOH HOH D . 
M 5 HOH 102 602 450 HOH HOH D . 
M 5 HOH 103 603 290 HOH HOH D . 
M 5 HOH 104 604 256 HOH HOH D . 
M 5 HOH 105 605 302 HOH HOH D . 
M 5 HOH 106 606 208 HOH HOH D . 
M 5 HOH 107 607 661 HOH HOH D . 
M 5 HOH 108 608 206 HOH HOH D . 
M 5 HOH 109 609 49  HOH HOH D . 
M 5 HOH 110 610 118 HOH HOH D . 
M 5 HOH 111 611 76  HOH HOH D . 
M 5 HOH 112 612 489 HOH HOH D . 
M 5 HOH 113 613 649 HOH HOH D . 
M 5 HOH 114 614 496 HOH HOH D . 
M 5 HOH 115 615 393 HOH HOH D . 
M 5 HOH 116 616 699 HOH HOH D . 
M 5 HOH 117 617 128 HOH HOH D . 
M 5 HOH 118 618 687 HOH HOH D . 
M 5 HOH 119 619 309 HOH HOH D . 
M 5 HOH 120 620 317 HOH HOH D . 
M 5 HOH 121 621 275 HOH HOH D . 
M 5 HOH 122 622 319 HOH HOH D . 
M 5 HOH 123 623 637 HOH HOH D . 
M 5 HOH 124 624 635 HOH HOH D . 
M 5 HOH 125 625 324 HOH HOH D . 
M 5 HOH 126 626 497 HOH HOH D . 
M 5 HOH 127 627 439 HOH HOH D . 
M 5 HOH 128 628 462 HOH HOH D . 
M 5 HOH 129 629 326 HOH HOH D . 
M 5 HOH 130 630 378 HOH HOH D . 
M 5 HOH 131 631 664 HOH HOH D . 
M 5 HOH 132 632 663 HOH HOH D . 
M 5 HOH 133 633 672 HOH HOH D . 
M 5 HOH 134 634 149 HOH HOH D . 
M 5 HOH 135 635 644 HOH HOH D . 
M 5 HOH 136 636 294 HOH HOH D . 
M 5 HOH 137 637 633 HOH HOH D . 
M 5 HOH 138 638 431 HOH HOH D . 
M 5 HOH 139 639 289 HOH HOH D . 
M 5 HOH 140 640 469 HOH HOH D . 
M 5 HOH 141 641 68  HOH HOH D . 
M 5 HOH 142 642 484 HOH HOH D . 
M 5 HOH 143 643 330 HOH HOH D . 
M 5 HOH 144 644 444 HOH HOH D . 
M 5 HOH 145 645 286 HOH HOH D . 
M 5 HOH 146 646 409 HOH HOH D . 
M 5 HOH 147 647 488 HOH HOH D . 
M 5 HOH 148 648 651 HOH HOH D . 
M 5 HOH 149 649 683 HOH HOH D . 
M 5 HOH 150 650 361 HOH HOH D . 
M 5 HOH 151 651 670 HOH HOH D . 
M 5 HOH 152 652 632 HOH HOH D . 
M 5 HOH 153 653 377 HOH HOH D . 
M 5 HOH 154 654 465 HOH HOH D . 
M 5 HOH 155 655 184 HOH HOH D . 
M 5 HOH 156 656 686 HOH HOH D . 
M 5 HOH 157 657 548 HOH HOH D . 
M 5 HOH 158 658 634 HOH HOH D . 
M 5 HOH 159 659 372 HOH HOH D . 
M 5 HOH 160 660 638 HOH HOH D . 
M 5 HOH 161 661 684 HOH HOH D . 
M 5 HOH 162 662 284 HOH HOH D . 
M 5 HOH 163 663 480 HOH HOH D . 
M 5 HOH 164 664 459 HOH HOH D . 
M 5 HOH 165 665 207 HOH HOH D . 
M 5 HOH 166 666 490 HOH HOH D . 
M 5 HOH 167 667 217 HOH HOH D . 
M 5 HOH 168 668 337 HOH HOH D . 
M 5 HOH 169 669 498 HOH HOH D . 
M 5 HOH 170 670 282 HOH HOH D . 
M 5 HOH 171 671 458 HOH HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? 5.8.0411 1 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS         ? ? ? .        2 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? XDS         ? ? ? .        3 
? phasing           ? ? ? ? ? ? ? ? ? ? ? MOLREP      ? ? ? .        4 
? 'model building'  ? ? ? ? ? ? ? ? ? ? ? Coot        ? ? ? .        5 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? .        6 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   91.44 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9F2H 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     93.056 
_cell.length_a_esd                 ? 
_cell.length_b                     43.383 
_cell.length_b_esd                 ? 
_cell.length_c                     109.326 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        16 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9F2H 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'I 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9F2H 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.12 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.05 
_exptl_crystal.description                  Rods 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;PEG 3350 38%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate and 1 mM InsP6. 
Protein:precipitant ratio 1:1. 
Protein concentration: 16.5 mg/ml. 
Protein buffer: 20 mM Tris pH 8.0 and 150 mM NaCl.    
Soaking o/n with saturated concentration of riluzole in PEG 3350 40%, 0.1 M Tris pH 8.5, 50 mM ammonium sulfate, 1 mM InsP6 condition.
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      'Toroidal mirror, elliptical beam shape' 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X CdTe 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-07-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    'Channel-cut Si(111)' 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.774899 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID23-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.774899 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID23-1 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          14.431 
_reflns.entry_id                                       9F2H 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.30 
_reflns.d_resolution_low                               46.56 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     103602 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           97.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.026 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.30 
_reflns_shell.d_res_low                                     1.32 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.9 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4726 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               4.7 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.363 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.685 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          89.9 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.29 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            0.38 
_refine.aniso_B[2][2]                            -0.23 
_refine.aniso_B[2][3]                            -0.00 
_refine.aniso_B[3][3]                            -0.08 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               17.108 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.975 
_refine.correlation_coeff_Fo_to_Fc_free          0.966 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9F2H 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.30 
_refine.ls_d_res_low                             46.56 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     98450 
_refine.ls_number_reflns_R_free                  5140 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.37 
_refine.ls_percent_reflns_R_free                 5.0 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.16856 
_refine.ls_R_factor_R_free                       0.18898 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.16750 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.052 
_refine.pdbx_overall_ESU_R_Free                  0.053 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             0.851 
_refine.overall_SU_ML                            0.036 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.30 
_refine_hist.d_res_low                        46.56 
_refine_hist.number_atoms_solvent             628 
_refine_hist.number_atoms_total               4150 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3488 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         34 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.006  0.012  3841 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  3573 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.360  1.669  5220 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.478  1.586  8243 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.531  5.000  476  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 7.485  5.000  31   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 14.081 10.000 659  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.074  0.200  526  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.008  0.020  4737 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  983  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 1.296  1.675  1850 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 1.295  1.675  1850 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 2.066  2.997  2344 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 2.066  2.997  2345 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 1.922  1.989  1991 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 1.922  1.990  1992 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 3.069  3.522  2877 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 4.711  21.66  4761 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 4.384  18.44  4519 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       1.300 
_refine_ls_shell.d_res_low                        1.334 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             344 
_refine_ls_shell.number_reflns_R_work             6822 
_refine_ls_shell.percent_reflns_obs               90.89 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.256 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.250 
# 
_struct.entry_id                     9F2H 
_struct.title                        'Crystal structure of SARS-CoV-2 N-protein C-terminal domain in complex with riluzole' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9F2H 
_struct_keywords.text            'CTD, SARS-CoV-2 nucleocapsid, COVID-19, riluzole, benzothiazols, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 1 ? 
E N N 2 ? 
F N N 3 ? 
G N N 3 ? 
H N N 4 ? 
I N N 3 ? 
J N N 5 ? 
K N N 5 ? 
L N N 5 ? 
M N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    NCAP_SARS2 
_struct_ref.pdbx_db_accession          P0DTC9 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;KKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTG
AIKLDDKDPNFKDQVILLNKHIDAYKTFP
;
_struct_ref.pdbx_align_begin           256 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9F2H A 3 ? 111 ? P0DTC9 256 ? 364 ? 256 364 
2 1 9F2H B 3 ? 111 ? P0DTC9 256 ? 364 ? 256 364 
3 1 9F2H C 3 ? 111 ? P0DTC9 256 ? 364 ? 256 364 
4 1 9F2H D 3 ? 111 ? P0DTC9 256 ? 364 ? 256 364 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9F2H GLY A 1 ? UNP P0DTC9 ? ? 'expression tag' 254 1 
1 9F2H SER A 2 ? UNP P0DTC9 ? ? 'expression tag' 255 2 
2 9F2H GLY B 1 ? UNP P0DTC9 ? ? 'expression tag' 254 3 
2 9F2H SER B 2 ? UNP P0DTC9 ? ? 'expression tag' 255 4 
3 9F2H GLY C 1 ? UNP P0DTC9 ? ? 'expression tag' 254 5 
3 9F2H SER C 2 ? UNP P0DTC9 ? ? 'expression tag' 255 6 
4 9F2H GLY D 1 ? UNP P0DTC9 ? ? 'expression tag' 254 7 
4 9F2H SER D 2 ? UNP P0DTC9 ? ? 'expression tag' 255 8 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5410  ? 
1 MORE         -42   ? 
1 'SSA (A^2)'  11510 ? 
2 'ABSA (A^2)' 5530  ? 
2 MORE         -32   ? 
2 'SSA (A^2)'  11430 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,E,F,G,J,K 
2 1 C,D,H,I,L,M   
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'NMR relaxation study' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 5   ? ARG A 9   ? PRO A 258 ARG A 262 5 ? 5  
HELX_P HELX_P2  AA2 ASN A 16  ? GLY A 22  ? ASN A 269 GLY A 275 1 ? 7  
HELX_P HELX_P3  AA3 ASP A 35  ? GLY A 42  ? ASP A 288 GLY A 295 1 ? 8  
HELX_P HELX_P4  AA4 THR A 43  ? TYR A 45  ? THR A 296 TYR A 298 5 ? 3  
HELX_P HELX_P5  AA5 HIS A 47  ? GLN A 53  ? HIS A 300 GLN A 306 1 ? 7  
HELX_P HELX_P6  AA6 SER A 57  ? SER A 65  ? SER A 310 SER A 318 1 ? 9  
HELX_P HELX_P7  AA7 ASN A 92  ? ILE A 104 ? ASN A 345 ILE A 357 1 ? 13 
HELX_P HELX_P8  AA8 ASP A 105 ? PHE A 110 ? ASP A 358 PHE A 363 5 ? 6  
HELX_P HELX_P9  AA9 PRO B 5   ? ARG B 9   ? PRO B 258 ARG B 262 5 ? 5  
HELX_P HELX_P10 AB1 ASN B 16  ? GLY B 22  ? ASN B 269 GLY B 275 1 ? 7  
HELX_P HELX_P11 AB2 ASP B 35  ? GLY B 42  ? ASP B 288 GLY B 295 1 ? 8  
HELX_P HELX_P12 AB3 THR B 43  ? TYR B 45  ? THR B 296 TYR B 298 5 ? 3  
HELX_P HELX_P13 AB4 HIS B 47  ? GLN B 53  ? HIS B 300 GLN B 306 1 ? 7  
HELX_P HELX_P14 AB5 SER B 57  ? SER B 65  ? SER B 310 SER B 318 1 ? 9  
HELX_P HELX_P15 AB6 ASN B 92  ? ILE B 104 ? ASN B 345 ILE B 357 1 ? 13 
HELX_P HELX_P16 AB7 ASP B 105 ? PHE B 110 ? ASP B 358 PHE B 363 5 ? 6  
HELX_P HELX_P17 AB8 PRO C 5   ? ARG C 9   ? PRO C 258 ARG C 262 5 ? 5  
HELX_P HELX_P18 AB9 ASN C 16  ? GLY C 22  ? ASN C 269 GLY C 275 1 ? 7  
HELX_P HELX_P19 AC1 ASP C 35  ? GLY C 42  ? ASP C 288 GLY C 295 1 ? 8  
HELX_P HELX_P20 AC2 THR C 43  ? TYR C 45  ? THR C 296 TYR C 298 5 ? 3  
HELX_P HELX_P21 AC3 HIS C 47  ? GLN C 53  ? HIS C 300 GLN C 306 1 ? 7  
HELX_P HELX_P22 AC4 SER C 57  ? SER C 65  ? SER C 310 SER C 318 1 ? 9  
HELX_P HELX_P23 AC5 ASN C 92  ? ILE C 104 ? ASN C 345 ILE C 357 1 ? 13 
HELX_P HELX_P24 AC6 ASP C 105 ? PHE C 110 ? ASP C 358 PHE C 363 5 ? 6  
HELX_P HELX_P25 AC7 PRO D 5   ? ARG D 9   ? PRO D 258 ARG D 262 5 ? 5  
HELX_P HELX_P26 AC8 ASN D 16  ? GLY D 22  ? ASN D 269 GLY D 275 1 ? 7  
HELX_P HELX_P27 AC9 ASP D 35  ? GLY D 42  ? ASP D 288 GLY D 295 1 ? 8  
HELX_P HELX_P28 AD1 THR D 43  ? TYR D 45  ? THR D 296 TYR D 298 5 ? 3  
HELX_P HELX_P29 AD2 HIS D 47  ? GLN D 53  ? HIS D 300 GLN D 306 1 ? 7  
HELX_P HELX_P30 AD3 SER D 57  ? SER D 65  ? SER D 310 SER D 318 1 ? 9  
HELX_P HELX_P31 AD4 ASN D 92  ? ILE D 104 ? ASN D 345 ILE D 357 1 ? 13 
HELX_P HELX_P32 AD5 ASP D 105 ? PHE D 110 ? ASP D 358 PHE D 363 5 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 66 ? THR A 72 ? ARG A 319 THR A 325 
AA1 2 GLY A 75 ? LYS A 85 ? GLY A 328 LYS A 338 
AA1 3 GLY B 75 ? LYS B 85 ? GLY B 328 LYS B 338 
AA1 4 ARG B 66 ? THR B 72 ? ARG B 319 THR B 325 
AA2 1 ARG C 66 ? THR C 72 ? ARG C 319 THR C 325 
AA2 2 GLY C 75 ? LYS C 85 ? GLY C 328 LYS C 338 
AA2 3 GLY D 75 ? LYS D 85 ? GLY D 328 LYS D 338 
AA2 4 ARG D 66 ? THR D 72 ? ARG D 319 THR D 325 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ARG A 66 ? N ARG A 319 O THR A 81 ? O THR A 334 
AA1 2 3 N ILE A 84 ? N ILE A 337 O LEU B 78 ? O LEU B 331 
AA1 3 4 O THR B 81 ? O THR B 334 N ARG B 66 ? N ARG B 319 
AA2 1 2 N GLU C 70 ? N GLU C 323 O TRP C 77 ? O TRP C 330 
AA2 2 3 N ILE C 84 ? N ILE C 337 O LEU D 78 ? O LEU D 331 
AA2 3 4 O THR D 81 ? O THR D 334 N ARG D 66 ? N ARG D 319 
# 
_pdbx_entry_details.entry_id                   9F2H 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    LYS 
_pdbx_validate_torsion.auth_asym_id    B 
_pdbx_validate_torsion.auth_seq_id     256 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             69.65 
_pdbx_validate_torsion.psi             -58.49 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     259 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    A 
_pdbx_validate_planes.rmsd            0.140 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY 254 ? A GLY 1 
2 1 Y 1 A SER 255 ? A SER 2 
3 1 Y 1 A LYS 256 ? A LYS 3 
4 1 Y 1 B GLY 254 ? B GLY 1 
5 1 Y 1 C GLY 254 ? C GLY 1 
6 1 Y 1 C SER 255 ? C SER 2 
7 1 Y 1 D GLY 254 ? D GLY 1 
8 1 Y 1 D SER 255 ? D SER 2 
9 1 Y 1 D LYS 256 ? D LYS 3 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
657 C4   C Y N 1   
657 N2   N N N 2   
657 C7   C N N 3   
657 C6   C Y N 4   
657 C8   C Y N 5   
657 C1   C Y N 6   
657 C2   C Y N 7   
657 C3   C Y N 8   
657 C5   C Y N 9   
657 O1   O N N 10  
657 F1   F N N 11  
657 F2   F N N 12  
657 F3   F N N 13  
657 S1   S Y N 14  
657 N1   N Y N 15  
657 H4   H N N 16  
657 H5   H N N 17  
657 H1   H N N 18  
657 H2   H N N 19  
657 H3   H N N 20  
ALA N    N N N 21  
ALA CA   C N S 22  
ALA C    C N N 23  
ALA O    O N N 24  
ALA CB   C N N 25  
ALA OXT  O N N 26  
ALA H    H N N 27  
ALA H2   H N N 28  
ALA HA   H N N 29  
ALA HB1  H N N 30  
ALA HB2  H N N 31  
ALA HB3  H N N 32  
ALA HXT  H N N 33  
ARG N    N N N 34  
ARG CA   C N S 35  
ARG C    C N N 36  
ARG O    O N N 37  
ARG CB   C N N 38  
ARG CG   C N N 39  
ARG CD   C N N 40  
ARG NE   N N N 41  
ARG CZ   C N N 42  
ARG NH1  N N N 43  
ARG NH2  N N N 44  
ARG OXT  O N N 45  
ARG H    H N N 46  
ARG H2   H N N 47  
ARG HA   H N N 48  
ARG HB2  H N N 49  
ARG HB3  H N N 50  
ARG HG2  H N N 51  
ARG HG3  H N N 52  
ARG HD2  H N N 53  
ARG HD3  H N N 54  
ARG HE   H N N 55  
ARG HH11 H N N 56  
ARG HH12 H N N 57  
ARG HH21 H N N 58  
ARG HH22 H N N 59  
ARG HXT  H N N 60  
ASN N    N N N 61  
ASN CA   C N S 62  
ASN C    C N N 63  
ASN O    O N N 64  
ASN CB   C N N 65  
ASN CG   C N N 66  
ASN OD1  O N N 67  
ASN ND2  N N N 68  
ASN OXT  O N N 69  
ASN H    H N N 70  
ASN H2   H N N 71  
ASN HA   H N N 72  
ASN HB2  H N N 73  
ASN HB3  H N N 74  
ASN HD21 H N N 75  
ASN HD22 H N N 76  
ASN HXT  H N N 77  
ASP N    N N N 78  
ASP CA   C N S 79  
ASP C    C N N 80  
ASP O    O N N 81  
ASP CB   C N N 82  
ASP CG   C N N 83  
ASP OD1  O N N 84  
ASP OD2  O N N 85  
ASP OXT  O N N 86  
ASP H    H N N 87  
ASP H2   H N N 88  
ASP HA   H N N 89  
ASP HB2  H N N 90  
ASP HB3  H N N 91  
ASP HD2  H N N 92  
ASP HXT  H N N 93  
EDO C1   C N N 94  
EDO O1   O N N 95  
EDO C2   C N N 96  
EDO O2   O N N 97  
EDO H11  H N N 98  
EDO H12  H N N 99  
EDO HO1  H N N 100 
EDO H21  H N N 101 
EDO H22  H N N 102 
EDO HO2  H N N 103 
GLN N    N N N 104 
GLN CA   C N S 105 
GLN C    C N N 106 
GLN O    O N N 107 
GLN CB   C N N 108 
GLN CG   C N N 109 
GLN CD   C N N 110 
GLN OE1  O N N 111 
GLN NE2  N N N 112 
GLN OXT  O N N 113 
GLN H    H N N 114 
GLN H2   H N N 115 
GLN HA   H N N 116 
GLN HB2  H N N 117 
GLN HB3  H N N 118 
GLN HG2  H N N 119 
GLN HG3  H N N 120 
GLN HE21 H N N 121 
GLN HE22 H N N 122 
GLN HXT  H N N 123 
GLU N    N N N 124 
GLU CA   C N S 125 
GLU C    C N N 126 
GLU O    O N N 127 
GLU CB   C N N 128 
GLU CG   C N N 129 
GLU CD   C N N 130 
GLU OE1  O N N 131 
GLU OE2  O N N 132 
GLU OXT  O N N 133 
GLU H    H N N 134 
GLU H2   H N N 135 
GLU HA   H N N 136 
GLU HB2  H N N 137 
GLU HB3  H N N 138 
GLU HG2  H N N 139 
GLU HG3  H N N 140 
GLU HE2  H N N 141 
GLU HXT  H N N 142 
GLY N    N N N 143 
GLY CA   C N N 144 
GLY C    C N N 145 
GLY O    O N N 146 
GLY OXT  O N N 147 
GLY H    H N N 148 
GLY H2   H N N 149 
GLY HA2  H N N 150 
GLY HA3  H N N 151 
GLY HXT  H N N 152 
HIS N    N N N 153 
HIS CA   C N S 154 
HIS C    C N N 155 
HIS O    O N N 156 
HIS CB   C N N 157 
HIS CG   C Y N 158 
HIS ND1  N Y N 159 
HIS CD2  C Y N 160 
HIS CE1  C Y N 161 
HIS NE2  N Y N 162 
HIS OXT  O N N 163 
HIS H    H N N 164 
HIS H2   H N N 165 
HIS HA   H N N 166 
HIS HB2  H N N 167 
HIS HB3  H N N 168 
HIS HD1  H N N 169 
HIS HD2  H N N 170 
HIS HE1  H N N 171 
HIS HE2  H N N 172 
HIS HXT  H N N 173 
HOH O    O N N 174 
HOH H1   H N N 175 
HOH H2   H N N 176 
ILE N    N N N 177 
ILE CA   C N S 178 
ILE C    C N N 179 
ILE O    O N N 180 
ILE CB   C N S 181 
ILE CG1  C N N 182 
ILE CG2  C N N 183 
ILE CD1  C N N 184 
ILE OXT  O N N 185 
ILE H    H N N 186 
ILE H2   H N N 187 
ILE HA   H N N 188 
ILE HB   H N N 189 
ILE HG12 H N N 190 
ILE HG13 H N N 191 
ILE HG21 H N N 192 
ILE HG22 H N N 193 
ILE HG23 H N N 194 
ILE HD11 H N N 195 
ILE HD12 H N N 196 
ILE HD13 H N N 197 
ILE HXT  H N N 198 
LEU N    N N N 199 
LEU CA   C N S 200 
LEU C    C N N 201 
LEU O    O N N 202 
LEU CB   C N N 203 
LEU CG   C N N 204 
LEU CD1  C N N 205 
LEU CD2  C N N 206 
LEU OXT  O N N 207 
LEU H    H N N 208 
LEU H2   H N N 209 
LEU HA   H N N 210 
LEU HB2  H N N 211 
LEU HB3  H N N 212 
LEU HG   H N N 213 
LEU HD11 H N N 214 
LEU HD12 H N N 215 
LEU HD13 H N N 216 
LEU HD21 H N N 217 
LEU HD22 H N N 218 
LEU HD23 H N N 219 
LEU HXT  H N N 220 
LYS N    N N N 221 
LYS CA   C N S 222 
LYS C    C N N 223 
LYS O    O N N 224 
LYS CB   C N N 225 
LYS CG   C N N 226 
LYS CD   C N N 227 
LYS CE   C N N 228 
LYS NZ   N N N 229 
LYS OXT  O N N 230 
LYS H    H N N 231 
LYS H2   H N N 232 
LYS HA   H N N 233 
LYS HB2  H N N 234 
LYS HB3  H N N 235 
LYS HG2  H N N 236 
LYS HG3  H N N 237 
LYS HD2  H N N 238 
LYS HD3  H N N 239 
LYS HE2  H N N 240 
LYS HE3  H N N 241 
LYS HZ1  H N N 242 
LYS HZ2  H N N 243 
LYS HZ3  H N N 244 
LYS HXT  H N N 245 
MET N    N N N 246 
MET CA   C N S 247 
MET C    C N N 248 
MET O    O N N 249 
MET CB   C N N 250 
MET CG   C N N 251 
MET SD   S N N 252 
MET CE   C N N 253 
MET OXT  O N N 254 
MET H    H N N 255 
MET H2   H N N 256 
MET HA   H N N 257 
MET HB2  H N N 258 
MET HB3  H N N 259 
MET HG2  H N N 260 
MET HG3  H N N 261 
MET HE1  H N N 262 
MET HE2  H N N 263 
MET HE3  H N N 264 
MET HXT  H N N 265 
PHE N    N N N 266 
PHE CA   C N S 267 
PHE C    C N N 268 
PHE O    O N N 269 
PHE CB   C N N 270 
PHE CG   C Y N 271 
PHE CD1  C Y N 272 
PHE CD2  C Y N 273 
PHE CE1  C Y N 274 
PHE CE2  C Y N 275 
PHE CZ   C Y N 276 
PHE OXT  O N N 277 
PHE H    H N N 278 
PHE H2   H N N 279 
PHE HA   H N N 280 
PHE HB2  H N N 281 
PHE HB3  H N N 282 
PHE HD1  H N N 283 
PHE HD2  H N N 284 
PHE HE1  H N N 285 
PHE HE2  H N N 286 
PHE HZ   H N N 287 
PHE HXT  H N N 288 
PRO N    N N N 289 
PRO CA   C N S 290 
PRO C    C N N 291 
PRO O    O N N 292 
PRO CB   C N N 293 
PRO CG   C N N 294 
PRO CD   C N N 295 
PRO OXT  O N N 296 
PRO H    H N N 297 
PRO HA   H N N 298 
PRO HB2  H N N 299 
PRO HB3  H N N 300 
PRO HG2  H N N 301 
PRO HG3  H N N 302 
PRO HD2  H N N 303 
PRO HD3  H N N 304 
PRO HXT  H N N 305 
SER N    N N N 306 
SER CA   C N S 307 
SER C    C N N 308 
SER O    O N N 309 
SER CB   C N N 310 
SER OG   O N N 311 
SER OXT  O N N 312 
SER H    H N N 313 
SER H2   H N N 314 
SER HA   H N N 315 
SER HB2  H N N 316 
SER HB3  H N N 317 
SER HG   H N N 318 
SER HXT  H N N 319 
SO4 S    S N N 320 
SO4 O1   O N N 321 
SO4 O2   O N N 322 
SO4 O3   O N N 323 
SO4 O4   O N N 324 
THR N    N N N 325 
THR CA   C N S 326 
THR C    C N N 327 
THR O    O N N 328 
THR CB   C N R 329 
THR OG1  O N N 330 
THR CG2  C N N 331 
THR OXT  O N N 332 
THR H    H N N 333 
THR H2   H N N 334 
THR HA   H N N 335 
THR HB   H N N 336 
THR HG1  H N N 337 
THR HG21 H N N 338 
THR HG22 H N N 339 
THR HG23 H N N 340 
THR HXT  H N N 341 
TRP N    N N N 342 
TRP CA   C N S 343 
TRP C    C N N 344 
TRP O    O N N 345 
TRP CB   C N N 346 
TRP CG   C Y N 347 
TRP CD1  C Y N 348 
TRP CD2  C Y N 349 
TRP NE1  N Y N 350 
TRP CE2  C Y N 351 
TRP CE3  C Y N 352 
TRP CZ2  C Y N 353 
TRP CZ3  C Y N 354 
TRP CH2  C Y N 355 
TRP OXT  O N N 356 
TRP H    H N N 357 
TRP H2   H N N 358 
TRP HA   H N N 359 
TRP HB2  H N N 360 
TRP HB3  H N N 361 
TRP HD1  H N N 362 
TRP HE1  H N N 363 
TRP HE3  H N N 364 
TRP HZ2  H N N 365 
TRP HZ3  H N N 366 
TRP HH2  H N N 367 
TRP HXT  H N N 368 
TYR N    N N N 369 
TYR CA   C N S 370 
TYR C    C N N 371 
TYR O    O N N 372 
TYR CB   C N N 373 
TYR CG   C Y N 374 
TYR CD1  C Y N 375 
TYR CD2  C Y N 376 
TYR CE1  C Y N 377 
TYR CE2  C Y N 378 
TYR CZ   C Y N 379 
TYR OH   O N N 380 
TYR OXT  O N N 381 
TYR H    H N N 382 
TYR H2   H N N 383 
TYR HA   H N N 384 
TYR HB2  H N N 385 
TYR HB3  H N N 386 
TYR HD1  H N N 387 
TYR HD2  H N N 388 
TYR HE1  H N N 389 
TYR HE2  H N N 390 
TYR HH   H N N 391 
TYR HXT  H N N 392 
VAL N    N N N 393 
VAL CA   C N S 394 
VAL C    C N N 395 
VAL O    O N N 396 
VAL CB   C N N 397 
VAL CG1  C N N 398 
VAL CG2  C N N 399 
VAL OXT  O N N 400 
VAL H    H N N 401 
VAL H2   H N N 402 
VAL HA   H N N 403 
VAL HB   H N N 404 
VAL HG11 H N N 405 
VAL HG12 H N N 406 
VAL HG13 H N N 407 
VAL HG21 H N N 408 
VAL HG22 H N N 409 
VAL HG23 H N N 410 
VAL HXT  H N N 411 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
657 N2  C8   sing N N 1   
657 S1  C8   sing Y N 2   
657 S1  C4   sing Y N 3   
657 C8  N1   doub Y N 4   
657 C4  C5   doub Y N 5   
657 C4  C3   sing Y N 6   
657 N1  C3   sing Y N 7   
657 C5  C6   sing Y N 8   
657 C3  C2   doub Y N 9   
657 C6  O1   sing N N 10  
657 C6  C1   doub Y N 11  
657 O1  C7   sing N N 12  
657 C2  C1   sing Y N 13  
657 F1  C7   sing N N 14  
657 C7  F3   sing N N 15  
657 C7  F2   sing N N 16  
657 N2  H4   sing N N 17  
657 N2  H5   sing N N 18  
657 C1  H1   sing N N 19  
657 C2  H2   sing N N 20  
657 C5  H3   sing N N 21  
ALA N   CA   sing N N 22  
ALA N   H    sing N N 23  
ALA N   H2   sing N N 24  
ALA CA  C    sing N N 25  
ALA CA  CB   sing N N 26  
ALA CA  HA   sing N N 27  
ALA C   O    doub N N 28  
ALA C   OXT  sing N N 29  
ALA CB  HB1  sing N N 30  
ALA CB  HB2  sing N N 31  
ALA CB  HB3  sing N N 32  
ALA OXT HXT  sing N N 33  
ARG N   CA   sing N N 34  
ARG N   H    sing N N 35  
ARG N   H2   sing N N 36  
ARG CA  C    sing N N 37  
ARG CA  CB   sing N N 38  
ARG CA  HA   sing N N 39  
ARG C   O    doub N N 40  
ARG C   OXT  sing N N 41  
ARG CB  CG   sing N N 42  
ARG CB  HB2  sing N N 43  
ARG CB  HB3  sing N N 44  
ARG CG  CD   sing N N 45  
ARG CG  HG2  sing N N 46  
ARG CG  HG3  sing N N 47  
ARG CD  NE   sing N N 48  
ARG CD  HD2  sing N N 49  
ARG CD  HD3  sing N N 50  
ARG NE  CZ   sing N N 51  
ARG NE  HE   sing N N 52  
ARG CZ  NH1  sing N N 53  
ARG CZ  NH2  doub N N 54  
ARG NH1 HH11 sing N N 55  
ARG NH1 HH12 sing N N 56  
ARG NH2 HH21 sing N N 57  
ARG NH2 HH22 sing N N 58  
ARG OXT HXT  sing N N 59  
ASN N   CA   sing N N 60  
ASN N   H    sing N N 61  
ASN N   H2   sing N N 62  
ASN CA  C    sing N N 63  
ASN CA  CB   sing N N 64  
ASN CA  HA   sing N N 65  
ASN C   O    doub N N 66  
ASN C   OXT  sing N N 67  
ASN CB  CG   sing N N 68  
ASN CB  HB2  sing N N 69  
ASN CB  HB3  sing N N 70  
ASN CG  OD1  doub N N 71  
ASN CG  ND2  sing N N 72  
ASN ND2 HD21 sing N N 73  
ASN ND2 HD22 sing N N 74  
ASN OXT HXT  sing N N 75  
ASP N   CA   sing N N 76  
ASP N   H    sing N N 77  
ASP N   H2   sing N N 78  
ASP CA  C    sing N N 79  
ASP CA  CB   sing N N 80  
ASP CA  HA   sing N N 81  
ASP C   O    doub N N 82  
ASP C   OXT  sing N N 83  
ASP CB  CG   sing N N 84  
ASP CB  HB2  sing N N 85  
ASP CB  HB3  sing N N 86  
ASP CG  OD1  doub N N 87  
ASP CG  OD2  sing N N 88  
ASP OD2 HD2  sing N N 89  
ASP OXT HXT  sing N N 90  
EDO C1  O1   sing N N 91  
EDO C1  C2   sing N N 92  
EDO C1  H11  sing N N 93  
EDO C1  H12  sing N N 94  
EDO O1  HO1  sing N N 95  
EDO C2  O2   sing N N 96  
EDO C2  H21  sing N N 97  
EDO C2  H22  sing N N 98  
EDO O2  HO2  sing N N 99  
GLN N   CA   sing N N 100 
GLN N   H    sing N N 101 
GLN N   H2   sing N N 102 
GLN CA  C    sing N N 103 
GLN CA  CB   sing N N 104 
GLN CA  HA   sing N N 105 
GLN C   O    doub N N 106 
GLN C   OXT  sing N N 107 
GLN CB  CG   sing N N 108 
GLN CB  HB2  sing N N 109 
GLN CB  HB3  sing N N 110 
GLN CG  CD   sing N N 111 
GLN CG  HG2  sing N N 112 
GLN CG  HG3  sing N N 113 
GLN CD  OE1  doub N N 114 
GLN CD  NE2  sing N N 115 
GLN NE2 HE21 sing N N 116 
GLN NE2 HE22 sing N N 117 
GLN OXT HXT  sing N N 118 
GLU N   CA   sing N N 119 
GLU N   H    sing N N 120 
GLU N   H2   sing N N 121 
GLU CA  C    sing N N 122 
GLU CA  CB   sing N N 123 
GLU CA  HA   sing N N 124 
GLU C   O    doub N N 125 
GLU C   OXT  sing N N 126 
GLU CB  CG   sing N N 127 
GLU CB  HB2  sing N N 128 
GLU CB  HB3  sing N N 129 
GLU CG  CD   sing N N 130 
GLU CG  HG2  sing N N 131 
GLU CG  HG3  sing N N 132 
GLU CD  OE1  doub N N 133 
GLU CD  OE2  sing N N 134 
GLU OE2 HE2  sing N N 135 
GLU OXT HXT  sing N N 136 
GLY N   CA   sing N N 137 
GLY N   H    sing N N 138 
GLY N   H2   sing N N 139 
GLY CA  C    sing N N 140 
GLY CA  HA2  sing N N 141 
GLY CA  HA3  sing N N 142 
GLY C   O    doub N N 143 
GLY C   OXT  sing N N 144 
GLY OXT HXT  sing N N 145 
HIS N   CA   sing N N 146 
HIS N   H    sing N N 147 
HIS N   H2   sing N N 148 
HIS CA  C    sing N N 149 
HIS CA  CB   sing N N 150 
HIS CA  HA   sing N N 151 
HIS C   O    doub N N 152 
HIS C   OXT  sing N N 153 
HIS CB  CG   sing N N 154 
HIS CB  HB2  sing N N 155 
HIS CB  HB3  sing N N 156 
HIS CG  ND1  sing Y N 157 
HIS CG  CD2  doub Y N 158 
HIS ND1 CE1  doub Y N 159 
HIS ND1 HD1  sing N N 160 
HIS CD2 NE2  sing Y N 161 
HIS CD2 HD2  sing N N 162 
HIS CE1 NE2  sing Y N 163 
HIS CE1 HE1  sing N N 164 
HIS NE2 HE2  sing N N 165 
HIS OXT HXT  sing N N 166 
HOH O   H1   sing N N 167 
HOH O   H2   sing N N 168 
ILE N   CA   sing N N 169 
ILE N   H    sing N N 170 
ILE N   H2   sing N N 171 
ILE CA  C    sing N N 172 
ILE CA  CB   sing N N 173 
ILE CA  HA   sing N N 174 
ILE C   O    doub N N 175 
ILE C   OXT  sing N N 176 
ILE CB  CG1  sing N N 177 
ILE CB  CG2  sing N N 178 
ILE CB  HB   sing N N 179 
ILE CG1 CD1  sing N N 180 
ILE CG1 HG12 sing N N 181 
ILE CG1 HG13 sing N N 182 
ILE CG2 HG21 sing N N 183 
ILE CG2 HG22 sing N N 184 
ILE CG2 HG23 sing N N 185 
ILE CD1 HD11 sing N N 186 
ILE CD1 HD12 sing N N 187 
ILE CD1 HD13 sing N N 188 
ILE OXT HXT  sing N N 189 
LEU N   CA   sing N N 190 
LEU N   H    sing N N 191 
LEU N   H2   sing N N 192 
LEU CA  C    sing N N 193 
LEU CA  CB   sing N N 194 
LEU CA  HA   sing N N 195 
LEU C   O    doub N N 196 
LEU C   OXT  sing N N 197 
LEU CB  CG   sing N N 198 
LEU CB  HB2  sing N N 199 
LEU CB  HB3  sing N N 200 
LEU CG  CD1  sing N N 201 
LEU CG  CD2  sing N N 202 
LEU CG  HG   sing N N 203 
LEU CD1 HD11 sing N N 204 
LEU CD1 HD12 sing N N 205 
LEU CD1 HD13 sing N N 206 
LEU CD2 HD21 sing N N 207 
LEU CD2 HD22 sing N N 208 
LEU CD2 HD23 sing N N 209 
LEU OXT HXT  sing N N 210 
LYS N   CA   sing N N 211 
LYS N   H    sing N N 212 
LYS N   H2   sing N N 213 
LYS CA  C    sing N N 214 
LYS CA  CB   sing N N 215 
LYS CA  HA   sing N N 216 
LYS C   O    doub N N 217 
LYS C   OXT  sing N N 218 
LYS CB  CG   sing N N 219 
LYS CB  HB2  sing N N 220 
LYS CB  HB3  sing N N 221 
LYS CG  CD   sing N N 222 
LYS CG  HG2  sing N N 223 
LYS CG  HG3  sing N N 224 
LYS CD  CE   sing N N 225 
LYS CD  HD2  sing N N 226 
LYS CD  HD3  sing N N 227 
LYS CE  NZ   sing N N 228 
LYS CE  HE2  sing N N 229 
LYS CE  HE3  sing N N 230 
LYS NZ  HZ1  sing N N 231 
LYS NZ  HZ2  sing N N 232 
LYS NZ  HZ3  sing N N 233 
LYS OXT HXT  sing N N 234 
MET N   CA   sing N N 235 
MET N   H    sing N N 236 
MET N   H2   sing N N 237 
MET CA  C    sing N N 238 
MET CA  CB   sing N N 239 
MET CA  HA   sing N N 240 
MET C   O    doub N N 241 
MET C   OXT  sing N N 242 
MET CB  CG   sing N N 243 
MET CB  HB2  sing N N 244 
MET CB  HB3  sing N N 245 
MET CG  SD   sing N N 246 
MET CG  HG2  sing N N 247 
MET CG  HG3  sing N N 248 
MET SD  CE   sing N N 249 
MET CE  HE1  sing N N 250 
MET CE  HE2  sing N N 251 
MET CE  HE3  sing N N 252 
MET OXT HXT  sing N N 253 
PHE N   CA   sing N N 254 
PHE N   H    sing N N 255 
PHE N   H2   sing N N 256 
PHE CA  C    sing N N 257 
PHE CA  CB   sing N N 258 
PHE CA  HA   sing N N 259 
PHE C   O    doub N N 260 
PHE C   OXT  sing N N 261 
PHE CB  CG   sing N N 262 
PHE CB  HB2  sing N N 263 
PHE CB  HB3  sing N N 264 
PHE CG  CD1  doub Y N 265 
PHE CG  CD2  sing Y N 266 
PHE CD1 CE1  sing Y N 267 
PHE CD1 HD1  sing N N 268 
PHE CD2 CE2  doub Y N 269 
PHE CD2 HD2  sing N N 270 
PHE CE1 CZ   doub Y N 271 
PHE CE1 HE1  sing N N 272 
PHE CE2 CZ   sing Y N 273 
PHE CE2 HE2  sing N N 274 
PHE CZ  HZ   sing N N 275 
PHE OXT HXT  sing N N 276 
PRO N   CA   sing N N 277 
PRO N   CD   sing N N 278 
PRO N   H    sing N N 279 
PRO CA  C    sing N N 280 
PRO CA  CB   sing N N 281 
PRO CA  HA   sing N N 282 
PRO C   O    doub N N 283 
PRO C   OXT  sing N N 284 
PRO CB  CG   sing N N 285 
PRO CB  HB2  sing N N 286 
PRO CB  HB3  sing N N 287 
PRO CG  CD   sing N N 288 
PRO CG  HG2  sing N N 289 
PRO CG  HG3  sing N N 290 
PRO CD  HD2  sing N N 291 
PRO CD  HD3  sing N N 292 
PRO OXT HXT  sing N N 293 
SER N   CA   sing N N 294 
SER N   H    sing N N 295 
SER N   H2   sing N N 296 
SER CA  C    sing N N 297 
SER CA  CB   sing N N 298 
SER CA  HA   sing N N 299 
SER C   O    doub N N 300 
SER C   OXT  sing N N 301 
SER CB  OG   sing N N 302 
SER CB  HB2  sing N N 303 
SER CB  HB3  sing N N 304 
SER OG  HG   sing N N 305 
SER OXT HXT  sing N N 306 
SO4 S   O1   doub N N 307 
SO4 S   O2   doub N N 308 
SO4 S   O3   sing N N 309 
SO4 S   O4   sing N N 310 
THR N   CA   sing N N 311 
THR N   H    sing N N 312 
THR N   H2   sing N N 313 
THR CA  C    sing N N 314 
THR CA  CB   sing N N 315 
THR CA  HA   sing N N 316 
THR C   O    doub N N 317 
THR C   OXT  sing N N 318 
THR CB  OG1  sing N N 319 
THR CB  CG2  sing N N 320 
THR CB  HB   sing N N 321 
THR OG1 HG1  sing N N 322 
THR CG2 HG21 sing N N 323 
THR CG2 HG22 sing N N 324 
THR CG2 HG23 sing N N 325 
THR OXT HXT  sing N N 326 
TRP N   CA   sing N N 327 
TRP N   H    sing N N 328 
TRP N   H2   sing N N 329 
TRP CA  C    sing N N 330 
TRP CA  CB   sing N N 331 
TRP CA  HA   sing N N 332 
TRP C   O    doub N N 333 
TRP C   OXT  sing N N 334 
TRP CB  CG   sing N N 335 
TRP CB  HB2  sing N N 336 
TRP CB  HB3  sing N N 337 
TRP CG  CD1  doub Y N 338 
TRP CG  CD2  sing Y N 339 
TRP CD1 NE1  sing Y N 340 
TRP CD1 HD1  sing N N 341 
TRP CD2 CE2  doub Y N 342 
TRP CD2 CE3  sing Y N 343 
TRP NE1 CE2  sing Y N 344 
TRP NE1 HE1  sing N N 345 
TRP CE2 CZ2  sing Y N 346 
TRP CE3 CZ3  doub Y N 347 
TRP CE3 HE3  sing N N 348 
TRP CZ2 CH2  doub Y N 349 
TRP CZ2 HZ2  sing N N 350 
TRP CZ3 CH2  sing Y N 351 
TRP CZ3 HZ3  sing N N 352 
TRP CH2 HH2  sing N N 353 
TRP OXT HXT  sing N N 354 
TYR N   CA   sing N N 355 
TYR N   H    sing N N 356 
TYR N   H2   sing N N 357 
TYR CA  C    sing N N 358 
TYR CA  CB   sing N N 359 
TYR CA  HA   sing N N 360 
TYR C   O    doub N N 361 
TYR C   OXT  sing N N 362 
TYR CB  CG   sing N N 363 
TYR CB  HB2  sing N N 364 
TYR CB  HB3  sing N N 365 
TYR CG  CD1  doub Y N 366 
TYR CG  CD2  sing Y N 367 
TYR CD1 CE1  sing Y N 368 
TYR CD1 HD1  sing N N 369 
TYR CD2 CE2  doub Y N 370 
TYR CD2 HD2  sing N N 371 
TYR CE1 CZ   doub Y N 372 
TYR CE1 HE1  sing N N 373 
TYR CE2 CZ   sing Y N 374 
TYR CE2 HE2  sing N N 375 
TYR CZ  OH   sing N N 376 
TYR OH  HH   sing N N 377 
TYR OXT HXT  sing N N 378 
VAL N   CA   sing N N 379 
VAL N   H    sing N N 380 
VAL N   H2   sing N N 381 
VAL CA  C    sing N N 382 
VAL CA  CB   sing N N 383 
VAL CA  HA   sing N N 384 
VAL C   O    doub N N 385 
VAL C   OXT  sing N N 386 
VAL CB  CG1  sing N N 387 
VAL CB  CG2  sing N N 388 
VAL CB  HB   sing N N 389 
VAL CG1 HG11 sing N N 390 
VAL CG1 HG12 sing N N 391 
VAL CG1 HG13 sing N N 392 
VAL CG2 HG21 sing N N 393 
VAL CG2 HG22 sing N N 394 
VAL CG2 HG23 sing N N 395 
VAL OXT HXT  sing N N 396 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Spanish Ministry of Science, Innovation, and Universities' Spain PID2020-117400GB-100           1 
'Spanish Ministry of Science, Innovation, and Universities' Spain MCIN/AEI/10.13039/501100011033 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   1 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7CE0 
_pdbx_initial_refinement_model.details          'Chain A' 
# 
_atom_sites.entry_id                    9F2H 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010746 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000271 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.023051 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009150 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
F 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LYS A 1 4   ? 17.705 -18.992 -6.494  1.00 33.05 ? 257 LYS A N   1 
ATOM   2    C CA  . LYS A 1 4   ? 17.465 -18.859 -5.033  1.00 30.37 ? 257 LYS A CA  1 
ATOM   3    C C   . LYS A 1 4   ? 18.715 -19.289 -4.280  1.00 25.11 ? 257 LYS A C   1 
ATOM   4    O O   . LYS A 1 4   ? 19.483 -20.113 -4.781  1.00 24.43 ? 257 LYS A O   1 
ATOM   5    C CB  . LYS A 1 4   ? 16.288 -19.727 -4.575  1.00 34.57 ? 257 LYS A CB  1 
ATOM   6    C CG  . LYS A 1 4   ? 14.917 -19.157 -4.898  1.00 38.90 ? 257 LYS A CG  1 
ATOM   7    C CD  . LYS A 1 4   ? 13.774 -20.116 -4.632  1.00 41.30 ? 257 LYS A CD  1 
ATOM   8    C CE  . LYS A 1 4   ? 12.481 -19.652 -5.275  1.00 44.45 ? 257 LYS A CE  1 
ATOM   9    N NZ  . LYS A 1 4   ? 11.477 -20.741 -5.367  1.00 46.15 ? 257 LYS A NZ  1 
ATOM   10   N N   . PRO A 1 5   ? 18.910 -18.824 -3.025  1.00 21.52 ? 258 PRO A N   1 
ATOM   11   C CA  . PRO A 1 5   ? 19.962 -19.365 -2.167  1.00 19.76 ? 258 PRO A CA  1 
ATOM   12   C C   . PRO A 1 5   ? 19.778 -20.872 -2.059  1.00 16.92 ? 258 PRO A C   1 
ATOM   13   O O   . PRO A 1 5   ? 18.649 -21.340 -2.005  1.00 17.47 ? 258 PRO A O   1 
ATOM   14   C CB  . PRO A 1 5   ? 19.712 -18.699 -0.803  1.00 20.98 ? 258 PRO A CB  1 
ATOM   15   C CG  . PRO A 1 5   ? 18.979 -17.411 -1.171  1.00 23.13 ? 258 PRO A CG  1 
ATOM   16   C CD  . PRO A 1 5   ? 18.114 -17.783 -2.359  1.00 23.57 ? 258 PRO A CD  1 
ATOM   17   N N   A ARG A 1 6   ? 20.884 -21.618 -2.046  0.50 16.35 ? 259 ARG A N   1 
ATOM   18   N N   B ARG A 1 6   ? 20.885 -21.619 -2.045  0.50 17.01 ? 259 ARG A N   1 
ATOM   19   C CA  A ARG A 1 6   ? 20.838 -23.070 -2.123  0.50 15.78 ? 259 ARG A CA  1 
ATOM   20   C CA  B ARG A 1 6   ? 20.833 -23.071 -2.125  0.50 16.89 ? 259 ARG A CA  1 
ATOM   21   C C   A ARG A 1 6   ? 19.876 -23.635 -1.074  0.50 15.44 ? 259 ARG A C   1 
ATOM   22   C C   B ARG A 1 6   ? 19.875 -23.636 -1.074  0.50 15.97 ? 259 ARG A C   1 
ATOM   23   O O   A ARG A 1 6   ? 19.070 -24.507 -1.380  0.50 15.69 ? 259 ARG A O   1 
ATOM   24   O O   B ARG A 1 6   ? 19.069 -24.508 -1.379  0.50 16.08 ? 259 ARG A O   1 
ATOM   25   C CB  A ARG A 1 6   ? 22.252 -23.621 -1.927  0.50 16.69 ? 259 ARG A CB  1 
ATOM   26   C CB  B ARG A 1 6   ? 22.232 -23.662 -1.949  0.50 18.86 ? 259 ARG A CB  1 
ATOM   27   C CG  A ARG A 1 6   ? 22.420 -25.072 -2.340  0.50 17.28 ? 259 ARG A CG  1 
ATOM   28   C CG  B ARG A 1 6   ? 22.290 -25.169 -2.156  0.50 20.61 ? 259 ARG A CG  1 
ATOM   29   C CD  A ARG A 1 6   ? 23.877 -25.476 -2.215  0.50 18.79 ? 259 ARG A CD  1 
ATOM   30   C CD  B ARG A 1 6   ? 23.713 -25.663 -2.225  0.50 22.37 ? 259 ARG A CD  1 
ATOM   31   N NE  A ARG A 1 6   ? 24.058 -26.864 -2.598  0.50 19.19 ? 259 ARG A NE  1 
ATOM   32   N NE  B ARG A 1 6   ? 24.354 -25.055 -3.378  0.50 22.81 ? 259 ARG A NE  1 
ATOM   33   C CZ  A ARG A 1 6   ? 24.488 -27.823 -1.791  0.50 18.34 ? 259 ARG A CZ  1 
ATOM   34   C CZ  B ARG A 1 6   ? 24.785 -25.722 -4.441  0.50 21.90 ? 259 ARG A CZ  1 
ATOM   35   N NH1 A ARG A 1 6   ? 25.364 -27.579 -0.835  0.50 19.41 ? 259 ARG A NH1 1 
ATOM   36   N NH1 B ARG A 1 6   ? 24.787 -27.043 -4.456  0.50 20.43 ? 259 ARG A NH1 1 
ATOM   37   N NH2 A ARG A 1 6   ? 24.097 -29.058 -2.007  0.50 15.08 ? 259 ARG A NH2 1 
ATOM   38   N NH2 B ARG A 1 6   ? 25.226 -25.049 -5.485  0.50 22.11 ? 259 ARG A NH2 1 
ATOM   39   N N   . GLN A 1 7   ? 19.949 -23.109 0.154   1.00 14.54 ? 260 GLN A N   1 
ATOM   40   C CA  . GLN A 1 7   ? 19.181 -23.661 1.262   1.00 14.58 ? 260 GLN A CA  1 
ATOM   41   C C   . GLN A 1 7   ? 17.676 -23.469 1.096   1.00 14.79 ? 260 GLN A C   1 
ATOM   42   O O   . GLN A 1 7   ? 16.907 -24.119 1.794   1.00 14.75 ? 260 GLN A O   1 
ATOM   43   C CB  . GLN A 1 7   ? 19.650 -23.072 2.594   1.00 14.31 ? 260 GLN A CB  1 
ATOM   44   C CG  . GLN A 1 7   ? 19.366 -21.588 2.792   1.00 15.47 ? 260 GLN A CG  1 
ATOM   45   C CD  . GLN A 1 7   ? 20.450 -20.675 2.272   1.00 16.25 ? 260 GLN A CD  1 
ATOM   46   O OE1 . GLN A 1 7   ? 21.293 -21.053 1.455   1.00 15.94 ? 260 GLN A OE1 1 
ATOM   47   N NE2 . GLN A 1 7   ? 20.424 -19.431 2.710   1.00 17.16 ? 260 GLN A NE2 1 
ATOM   48   N N   . LYS A 1 8   ? 17.239 -22.583 0.193   1.00 14.60 ? 261 LYS A N   1 
ATOM   49   C CA  . LYS A 1 8   ? 15.819 -22.343 -0.014  1.00 15.93 ? 261 LYS A CA  1 
ATOM   50   C C   . LYS A 1 8   ? 15.297 -23.014 -1.278  1.00 16.83 ? 261 LYS A C   1 
ATOM   51   O O   . LYS A 1 8   ? 14.112 -22.891 -1.587  1.00 18.75 ? 261 LYS A O   1 
ATOM   52   C CB  . LYS A 1 8   ? 15.547 -20.839 -0.089  1.00 17.21 ? 261 LYS A CB  1 
ATOM   53   C CG  . LYS A 1 8   ? 15.794 -20.081 1.208   1.00 17.81 ? 261 LYS A CG  1 
ATOM   54   C CD  . LYS A 1 8   ? 15.082 -20.681 2.391   1.00 18.69 ? 261 LYS A CD  1 
ATOM   55   C CE  . LYS A 1 8   ? 15.182 -19.830 3.638   1.00 18.43 ? 261 LYS A CE  1 
ATOM   56   N NZ  . LYS A 1 8   ? 14.497 -20.480 4.776   1.00 18.75 ? 261 LYS A NZ  1 
ATOM   57   N N   . ARG A 1 9   ? 16.157 -23.739 -1.996  1.00 15.26 ? 262 ARG A N   1 
ATOM   58   C CA  . ARG A 1 9   ? 15.734 -24.358 -3.238  1.00 15.99 ? 262 ARG A CA  1 
ATOM   59   C C   . ARG A 1 9   ? 14.799 -25.522 -2.958  1.00 16.13 ? 262 ARG A C   1 
ATOM   60   O O   . ARG A 1 9   ? 14.875 -26.162 -1.912  1.00 15.92 ? 262 ARG A O   1 
ATOM   61   C CB  . ARG A 1 9   ? 16.932 -24.833 -4.043  1.00 16.03 ? 262 ARG A CB  1 
ATOM   62   C CG  . ARG A 1 9   ? 17.763 -23.684 -4.560  1.00 15.62 ? 262 ARG A CG  1 
ATOM   63   C CD  . ARG A 1 9   ? 19.050 -24.144 -5.189  1.00 16.65 ? 262 ARG A CD  1 
ATOM   64   N NE  . ARG A 1 9   ? 19.861 -22.996 -5.550  1.00 18.89 ? 262 ARG A NE  1 
ATOM   65   C CZ  . ARG A 1 9   ? 21.078 -23.071 -6.062  1.00 20.96 ? 262 ARG A CZ  1 
ATOM   66   N NH1 . ARG A 1 9   ? 21.725 -21.971 -6.403  1.00 23.36 ? 262 ARG A NH1 1 
ATOM   67   N NH2 . ARG A 1 9   ? 21.632 -24.247 -6.304  1.00 21.34 ? 262 ARG A NH2 1 
ATOM   68   N N   . THR A 1 10  ? 13.945 -25.805 -3.937  1.00 16.57 ? 263 THR A N   1 
ATOM   69   C CA  . THR A 1 10  ? 13.041 -26.935 -3.886  1.00 18.53 ? 263 THR A CA  1 
ATOM   70   C C   . THR A 1 10  ? 13.272 -27.773 -5.133  1.00 17.69 ? 263 THR A C   1 
ATOM   71   O O   . THR A 1 10  ? 13.016 -27.306 -6.250  1.00 19.76 ? 263 THR A O   1 
ATOM   72   C CB  . THR A 1 10  ? 11.573 -26.493 -3.839  1.00 20.95 ? 263 THR A CB  1 
ATOM   73   O OG1 . THR A 1 10  ? 11.400 -25.627 -2.716  1.00 23.92 ? 263 THR A OG1 1 
ATOM   74   C CG2 . THR A 1 10  ? 10.615 -27.657 -3.728  1.00 22.28 ? 263 THR A CG2 1 
ATOM   75   N N   . ALA A 1 11  ? 13.759 -28.995 -4.954  1.00 16.22 ? 264 ALA A N   1 
ATOM   76   C CA  . ALA A 1 11  ? 13.971 -29.870 -6.093  1.00 17.18 ? 264 ALA A CA  1 
ATOM   77   C C   . ALA A 1 11  ? 12.633 -30.442 -6.536  1.00 18.58 ? 264 ALA A C   1 
ATOM   78   O O   . ALA A 1 11  ? 11.783 -30.762 -5.709  1.00 17.57 ? 264 ALA A O   1 
ATOM   79   C CB  . ALA A 1 11  ? 14.933 -30.974 -5.769  1.00 16.66 ? 264 ALA A CB  1 
ATOM   80   N N   . THR A 1 12  ? 12.490 -30.563 -7.862  1.00 18.57 ? 265 THR A N   1 
ATOM   81   C CA  . THR A 1 12  ? 11.308 -31.100 -8.509  1.00 19.77 ? 265 THR A CA  1 
ATOM   82   C C   . THR A 1 12  ? 11.784 -31.830 -9.757  1.00 20.22 ? 265 THR A C   1 
ATOM   83   O O   . THR A 1 12  ? 12.974 -31.799 -10.085 1.00 20.04 ? 265 THR A O   1 
ATOM   84   C CB  . THR A 1 12  ? 10.336 -29.988 -8.924  1.00 20.90 ? 265 THR A CB  1 
ATOM   85   O OG1 . THR A 1 12  ? 10.971 -29.198 -9.928  1.00 23.99 ? 265 THR A OG1 1 
ATOM   86   C CG2 . THR A 1 12  ? 9.933  -29.063 -7.798  1.00 21.48 ? 265 THR A CG2 1 
ATOM   87   N N   . LYS A 1 13  ? 10.842 -32.419 -10.496 1.00 22.62 ? 266 LYS A N   1 
ATOM   88   C CA  . LYS A 1 13  ? 11.193 -33.028 -11.768 1.00 24.08 ? 266 LYS A CA  1 
ATOM   89   C C   . LYS A 1 13  ? 11.833 -31.999 -12.700 1.00 23.18 ? 266 LYS A C   1 
ATOM   90   O O   . LYS A 1 13  ? 12.754 -32.346 -13.426 1.00 23.58 ? 266 LYS A O   1 
ATOM   91   C CB  . LYS A 1 13  ? 9.959  -33.673 -12.405 1.00 26.04 ? 266 LYS A CB  1 
ATOM   92   C CG  . LYS A 1 13  ? 9.575  -35.006 -11.783 1.00 28.66 ? 266 LYS A CG  1 
ATOM   93   C CD  . LYS A 1 13  ? 8.513  -35.771 -12.553 1.00 32.44 ? 266 LYS A CD  1 
ATOM   94   C CE  . LYS A 1 13  ? 7.232  -36.019 -11.787 1.00 35.63 ? 266 LYS A CE  1 
ATOM   95   N NZ  . LYS A 1 13  ? 6.326  -36.906 -12.551 1.00 36.95 ? 266 LYS A NZ  1 
ATOM   96   N N   . ALA A 1 14  ? 11.374 -30.744 -12.657 1.00 21.96 ? 267 ALA A N   1 
ATOM   97   C CA  . ALA A 1 14  ? 11.872 -29.700 -13.546 1.00 24.37 ? 267 ALA A CA  1 
ATOM   98   C C   . ALA A 1 14  ? 13.240 -29.173 -13.115 1.00 23.65 ? 267 ALA A C   1 
ATOM   99   O O   . ALA A 1 14  ? 13.973 -28.596 -13.914 1.00 25.58 ? 267 ALA A O   1 
ATOM   100  C CB  . ALA A 1 14  ? 10.878 -28.570 -13.600 1.00 25.40 ? 267 ALA A CB  1 
ATOM   101  N N   . TYR A 1 15  ? 13.572 -29.343 -11.832 1.00 21.20 ? 268 TYR A N   1 
ATOM   102  C CA  . TYR A 1 15  ? 14.777 -28.788 -11.245 1.00 20.44 ? 268 TYR A CA  1 
ATOM   103  C C   . TYR A 1 15  ? 15.246 -29.788 -10.202 1.00 19.16 ? 268 TYR A C   1 
ATOM   104  O O   . TYR A 1 15  ? 14.866 -29.683 -9.039  1.00 18.99 ? 268 TYR A O   1 
ATOM   105  C CB  . TYR A 1 15  ? 14.476 -27.413 -10.644 1.00 20.09 ? 268 TYR A CB  1 
ATOM   106  C CG  . TYR A 1 15  ? 15.649 -26.663 -10.057 1.00 20.32 ? 268 TYR A CG  1 
ATOM   107  C CD1 . TYR A 1 15  ? 16.809 -26.446 -10.780 1.00 21.12 ? 268 TYR A CD1 1 
ATOM   108  C CD2 . TYR A 1 15  ? 15.576 -26.110 -8.792  1.00 19.46 ? 268 TYR A CD2 1 
ATOM   109  C CE1 . TYR A 1 15  ? 17.858 -25.707 -10.264 1.00 20.41 ? 268 TYR A CE1 1 
ATOM   110  C CE2 . TYR A 1 15  ? 16.618 -25.371 -8.255  1.00 20.47 ? 268 TYR A CE2 1 
ATOM   111  C CZ  . TYR A 1 15  ? 17.770 -25.169 -8.991  1.00 18.73 ? 268 TYR A CZ  1 
ATOM   112  O OH  . TYR A 1 15  ? 18.823 -24.465 -8.484  1.00 20.69 ? 268 TYR A OH  1 
ATOM   113  N N   . ASN A 1 16  ? 16.007 -30.789 -10.634 1.00 18.04 ? 269 ASN A N   1 
ATOM   114  C CA  . ASN A 1 16  ? 16.108 -32.014 -9.858  1.00 18.05 ? 269 ASN A CA  1 
ATOM   115  C C   . ASN A 1 16  ? 17.181 -31.854 -8.778  1.00 17.01 ? 269 ASN A C   1 
ATOM   116  O O   . ASN A 1 16  ? 17.772 -30.793 -8.594  1.00 17.10 ? 269 ASN A O   1 
ATOM   117  C CB  . ASN A 1 16  ? 16.284 -33.240 -10.756 1.00 18.42 ? 269 ASN A CB  1 
ATOM   118  C CG  . ASN A 1 16  ? 17.615 -33.253 -11.472 1.00 19.24 ? 269 ASN A CG  1 
ATOM   119  O OD1 . ASN A 1 16  ? 18.608 -32.778 -10.945 1.00 18.77 ? 269 ASN A OD1 1 
ATOM   120  N ND2 . ASN A 1 16  ? 17.647 -33.729 -12.711 1.00 20.59 ? 269 ASN A ND2 1 
ATOM   121  N N   . VAL A 1 17  ? 17.386 -32.914 -8.006  1.00 15.83 ? 270 VAL A N   1 
ATOM   122  C CA  . VAL A 1 17  ? 18.276 -32.829 -6.861  1.00 15.28 ? 270 VAL A CA  1 
ATOM   123  C C   . VAL A 1 17  ? 19.690 -32.499 -7.310  1.00 16.14 ? 270 VAL A C   1 
ATOM   124  O O   . VAL A 1 17  ? 20.374 -31.735 -6.645  1.00 15.79 ? 270 VAL A O   1 
ATOM   125  C CB  . VAL A 1 17  ? 18.207 -34.121 -6.035  1.00 14.67 ? 270 VAL A CB  1 
ATOM   126  C CG1 . VAL A 1 17  ? 19.287 -34.207 -4.982  1.00 14.42 ? 270 VAL A CG1 1 
ATOM   127  C CG2 . VAL A 1 17  ? 16.841 -34.282 -5.394  1.00 15.22 ? 270 VAL A CG2 1 
ATOM   128  N N   . THR A 1 18  ? 20.136 -33.082 -8.427  1.00 15.74 ? 271 THR A N   1 
ATOM   129  C CA  . THR A 1 18  ? 21.459 -32.780 -8.950  1.00 16.47 ? 271 THR A CA  1 
ATOM   130  C C   . THR A 1 18  ? 21.565 -31.314 -9.357  1.00 16.06 ? 271 THR A C   1 
ATOM   131  O O   . THR A 1 18  ? 22.539 -30.646 -9.041  1.00 17.26 ? 271 THR A O   1 
ATOM   132  C CB  . THR A 1 18  ? 21.791 -33.667 -10.153 1.00 17.12 ? 271 THR A CB  1 
ATOM   133  O OG1 . THR A 1 18  ? 21.644 -35.019 -9.719  1.00 18.02 ? 271 THR A OG1 1 
ATOM   134  C CG2 . THR A 1 18  ? 23.177 -33.419 -10.707 1.00 18.96 ? 271 THR A CG2 1 
ATOM   135  N N   . GLN A 1 19  ? 20.543 -30.816 -10.051 1.00 15.72 ? 272 GLN A N   1 
ATOM   136  C CA  . GLN A 1 19  ? 20.550 -29.445 -10.529 1.00 17.45 ? 272 GLN A CA  1 
ATOM   137  C C   . GLN A 1 19  ? 20.538 -28.472 -9.352  1.00 17.03 ? 272 GLN A C   1 
ATOM   138  O O   . GLN A 1 19  ? 21.240 -27.467 -9.366  1.00 17.77 ? 272 GLN A O   1 
ATOM   139  C CB  . GLN A 1 19  ? 19.372 -29.223 -11.473 1.00 18.67 ? 272 GLN A CB  1 
ATOM   140  C CG  . GLN A 1 19  ? 19.471 -30.036 -12.756 1.00 20.29 ? 272 GLN A CG  1 
ATOM   141  C CD  . GLN A 1 19  ? 18.237 -29.963 -13.616 1.00 22.88 ? 272 GLN A CD  1 
ATOM   142  O OE1 . GLN A 1 19  ? 17.124 -30.282 -13.202 1.00 21.35 ? 272 GLN A OE1 1 
ATOM   143  N NE2 . GLN A 1 19  ? 18.440 -29.599 -14.874 1.00 25.04 ? 272 GLN A NE2 1 
ATOM   144  N N   . ALA A 1 20  ? 19.752 -28.780 -8.316  1.00 16.48 ? 273 ALA A N   1 
ATOM   145  C CA  . ALA A 1 20  ? 19.579 -27.865 -7.198  1.00 16.12 ? 273 ALA A CA  1 
ATOM   146  C C   . ALA A 1 20  ? 20.717 -27.972 -6.184  1.00 15.55 ? 273 ALA A C   1 
ATOM   147  O O   . ALA A 1 20  ? 21.148 -26.966 -5.612  1.00 15.92 ? 273 ALA A O   1 
ATOM   148  C CB  . ALA A 1 20  ? 18.264 -28.121 -6.516  1.00 16.65 ? 273 ALA A CB  1 
ATOM   149  N N   . PHE A 1 21  ? 21.195 -29.196 -5.949  1.00 14.83 ? 274 PHE A N   1 
ATOM   150  C CA  . PHE A 1 21  ? 22.013 -29.471 -4.776  1.00 14.92 ? 274 PHE A CA  1 
ATOM   151  C C   . PHE A 1 21  ? 23.300 -30.211 -5.109  1.00 15.17 ? 274 PHE A C   1 
ATOM   152  O O   . PHE A 1 21  ? 24.045 -30.556 -4.203  1.00 15.81 ? 274 PHE A O   1 
ATOM   153  C CB  . PHE A 1 21  ? 21.211 -30.282 -3.761  1.00 14.44 ? 274 PHE A CB  1 
ATOM   154  C CG  . PHE A 1 21  ? 19.942 -29.602 -3.333  1.00 13.93 ? 274 PHE A CG  1 
ATOM   155  C CD1 . PHE A 1 21  ? 18.716 -30.219 -3.499  1.00 13.85 ? 274 PHE A CD1 1 
ATOM   156  C CD2 . PHE A 1 21  ? 19.972 -28.324 -2.801  1.00 13.68 ? 274 PHE A CD2 1 
ATOM   157  C CE1 . PHE A 1 21  ? 17.550 -29.590 -3.100  1.00 14.41 ? 274 PHE A CE1 1 
ATOM   158  C CE2 . PHE A 1 21  ? 18.799 -27.680 -2.451  1.00 14.46 ? 274 PHE A CE2 1 
ATOM   159  C CZ  . PHE A 1 21  ? 17.594 -28.319 -2.590  1.00 14.42 ? 274 PHE A CZ  1 
ATOM   160  N N   . GLY A 1 22  ? 23.575 -30.424 -6.402  1.00 15.84 ? 275 GLY A N   1 
ATOM   161  C CA  . GLY A 1 22  ? 24.818 -31.047 -6.814  1.00 16.84 ? 275 GLY A CA  1 
ATOM   162  C C   . GLY A 1 22  ? 24.721 -32.570 -6.800  1.00 17.33 ? 275 GLY A C   1 
ATOM   163  O O   . GLY A 1 22  ? 23.826 -33.170 -6.191  1.00 16.85 ? 275 GLY A O   1 
ATOM   164  N N   . ARG A 1 23  ? 25.677 -33.201 -7.492  1.00 18.44 ? 276 ARG A N   1 
ATOM   165  C CA  . ARG A 1 23  ? 25.778 -34.644 -7.521  1.00 20.58 ? 276 ARG A CA  1 
ATOM   166  C C   . ARG A 1 23  ? 25.925 -35.161 -6.094  1.00 18.59 ? 276 ARG A C   1 
ATOM   167  O O   . ARG A 1 23  ? 26.580 -34.530 -5.259  1.00 17.31 ? 276 ARG A O   1 
ATOM   168  C CB  . ARG A 1 23  ? 26.982 -35.053 -8.381  1.00 25.08 ? 276 ARG A CB  1 
ATOM   169  C CG  . ARG A 1 23  ? 26.989 -36.506 -8.830  1.00 32.70 ? 276 ARG A CG  1 
ATOM   170  C CD  . ARG A 1 23  ? 27.774 -36.719 -10.118 1.00 38.26 ? 276 ARG A CD  1 
ATOM   171  N NE  . ARG A 1 23  ? 27.798 -38.109 -10.572 1.00 42.18 ? 276 ARG A NE  1 
ATOM   172  C CZ  . ARG A 1 23  ? 27.421 -38.542 -11.776 1.00 47.36 ? 276 ARG A CZ  1 
ATOM   173  N NH1 . ARG A 1 23  ? 27.599 -39.812 -12.099 1.00 49.24 ? 276 ARG A NH1 1 
ATOM   174  N NH2 . ARG A 1 23  ? 26.894 -37.714 -12.666 1.00 49.51 ? 276 ARG A NH2 1 
ATOM   175  N N   A ARG A 1 24  ? 25.310 -36.319 -5.832  0.50 17.48 ? 277 ARG A N   1 
ATOM   176  N N   B ARG A 1 24  ? 25.321 -36.323 -5.845  0.50 17.94 ? 277 ARG A N   1 
ATOM   177  C CA  A ARG A 1 24  ? 25.464 -36.990 -4.549  0.50 17.72 ? 277 ARG A CA  1 
ATOM   178  C CA  B ARG A 1 24  ? 25.519 -37.019 -4.587  0.50 18.45 ? 277 ARG A CA  1 
ATOM   179  C C   A ARG A 1 24  ? 26.907 -37.464 -4.441  0.50 19.64 ? 277 ARG A C   1 
ATOM   180  C C   B ARG A 1 24  ? 26.977 -37.425 -4.463  0.50 20.41 ? 277 ARG A C   1 
ATOM   181  O O   A ARG A 1 24  ? 27.483 -37.872 -5.450  0.50 20.50 ? 277 ARG A O   1 
ATOM   182  O O   B ARG A 1 24  ? 27.617 -37.791 -5.454  0.50 21.78 ? 277 ARG A O   1 
ATOM   183  C CB  A ARG A 1 24  ? 24.492 -38.175 -4.422  0.50 16.19 ? 277 ARG A CB  1 
ATOM   184  C CB  B ARG A 1 24  ? 24.786 -38.353 -4.555  0.50 17.37 ? 277 ARG A CB  1 
ATOM   185  C CG  A ARG A 1 24  ? 23.198 -37.874 -3.660  0.50 15.36 ? 277 ARG A CG  1 
ATOM   186  C CG  B ARG A 1 24  ? 23.334 -38.310 -4.969  0.50 16.68 ? 277 ARG A CG  1 
ATOM   187  C CD  A ARG A 1 24  ? 22.191 -37.082 -4.461  0.50 15.74 ? 277 ARG A CD  1 
ATOM   188  C CD  B ARG A 1 24  ? 22.613 -37.421 -3.997  0.50 15.65 ? 277 ARG A CD  1 
ATOM   189  N NE  A ARG A 1 24  ? 22.506 -35.673 -4.508  0.50 15.72 ? 277 ARG A NE  1 
ATOM   190  N NE  B ARG A 1 24  ? 22.852 -35.996 -4.210  0.50 15.57 ? 277 ARG A NE  1 
ATOM   191  C CZ  A ARG A 1 24  ? 22.372 -34.868 -3.462  0.50 15.28 ? 277 ARG A CZ  1 
ATOM   192  C CZ  B ARG A 1 24  ? 22.421 -35.024 -3.405  0.50 15.23 ? 277 ARG A CZ  1 
ATOM   193  N NH1 A ARG A 1 24  ? 22.830 -33.628 -3.535  0.50 15.62 ? 277 ARG A NH1 1 
ATOM   194  N NH1 B ARG A 1 24  ? 22.626 -33.752 -3.697  0.50 15.02 ? 277 ARG A NH1 1 
ATOM   195  N NH2 A ARG A 1 24  ? 21.832 -35.338 -2.342  0.50 15.33 ? 277 ARG A NH2 1 
ATOM   196  N NH2 B ARG A 1 24  ? 21.794 -35.334 -2.282  0.50 15.17 ? 277 ARG A NH2 1 
ATOM   197  N N   . GLY A 1 25  ? 27.504 -37.366 -3.249  1.00 20.32 ? 278 GLY A N   1 
ATOM   198  C CA  . GLY A 1 25  ? 28.832 -37.877 -3.046  1.00 22.22 ? 278 GLY A CA  1 
ATOM   199  C C   . GLY A 1 25  ? 29.240 -37.840 -1.588  1.00 22.45 ? 278 GLY A C   1 
ATOM   200  O O   . GLY A 1 25  ? 28.457 -37.478 -0.703  1.00 21.41 ? 278 GLY A O   1 
ATOM   201  N N   . PRO A 1 26  ? 30.512 -38.210 -1.331  1.00 25.20 ? 279 PRO A N   1 
ATOM   202  C CA  . PRO A 1 26  ? 31.044 -38.315 0.022   1.00 26.55 ? 279 PRO A CA  1 
ATOM   203  C C   . PRO A 1 26  ? 31.669 -37.053 0.604   1.00 26.79 ? 279 PRO A C   1 
ATOM   204  O O   . PRO A 1 26  ? 32.045 -37.025 1.771   1.00 25.36 ? 279 PRO A O   1 
ATOM   205  C CB  . PRO A 1 26  ? 32.159 -39.351 -0.192  1.00 26.74 ? 279 PRO A CB  1 
ATOM   206  C CG  . PRO A 1 26  ? 32.690 -39.046 -1.582  1.00 27.23 ? 279 PRO A CG  1 
ATOM   207  C CD  . PRO A 1 26  ? 31.470 -38.628 -2.374  1.00 26.68 ? 279 PRO A CD  1 
ATOM   208  N N   . GLU A 1 27  ? 31.799 -36.006 -0.219  1.00 25.98 ? 280 GLU A N   1 
ATOM   209  C CA  . GLU A 1 27  ? 32.575 -34.843 0.158   1.00 27.85 ? 280 GLU A CA  1 
ATOM   210  C C   . GLU A 1 27  ? 31.795 -34.026 1.174   1.00 26.81 ? 280 GLU A C   1 
ATOM   211  O O   . GLU A 1 27  ? 30.573 -34.131 1.319   1.00 24.51 ? 280 GLU A O   1 
ATOM   212  C CB  . GLU A 1 27  ? 32.960 -34.030 -1.079  1.00 30.52 ? 280 GLU A CB  1 
ATOM   213  C CG  . GLU A 1 27  ? 33.861 -34.814 -2.005  1.00 34.38 ? 280 GLU A CG  1 
ATOM   214  C CD  . GLU A 1 27  ? 35.273 -34.913 -1.459  1.00 38.65 ? 280 GLU A CD  1 
ATOM   215  O OE1 . GLU A 1 27  ? 35.697 -36.012 -1.030  1.00 41.94 ? 280 GLU A OE1 1 
ATOM   216  O OE2 . GLU A 1 27  ? 35.954 -33.874 -1.473  1.00 40.82 ? 280 GLU A OE2 1 
ATOM   217  N N   . GLN A 1 28  ? 32.525 -33.160 1.866   1.00 25.91 ? 281 GLN A N   1 
ATOM   218  C CA  . GLN A 1 28  ? 32.010 -32.475 3.036   1.00 26.11 ? 281 GLN A CA  1 
ATOM   219  C C   . GLN A 1 28  ? 30.746 -31.665 2.733   1.00 27.42 ? 281 GLN A C   1 
ATOM   220  O O   . GLN A 1 28  ? 29.822 -31.652 3.548   1.00 25.60 ? 281 GLN A O   1 
ATOM   221  C CB  . GLN A 1 28  ? 33.080 -31.570 3.637   1.00 30.47 ? 281 GLN A CB  1 
ATOM   222  C CG  . GLN A 1 28  ? 32.661 -31.014 4.984   1.00 30.38 ? 281 GLN A CG  1 
ATOM   223  C CD  . GLN A 1 28  ? 33.754 -30.298 5.737   1.00 34.71 ? 281 GLN A CD  1 
ATOM   224  O OE1 . GLN A 1 28  ? 33.612 -30.026 6.925   1.00 35.91 ? 281 GLN A OE1 1 
ATOM   225  N NE2 . GLN A 1 28  ? 34.849 -29.979 5.067   1.00 36.45 ? 281 GLN A NE2 1 
ATOM   226  N N   . THR A 1 29  ? 30.711 -30.979 1.583   1.00 25.17 ? 282 THR A N   1 
ATOM   227  C CA  . THR A 1 29  ? 29.574 -30.124 1.283   1.00 23.52 ? 282 THR A CA  1 
ATOM   228  C C   . THR A 1 29  ? 28.767 -30.717 0.133   1.00 21.63 ? 282 THR A C   1 
ATOM   229  O O   . THR A 1 29  ? 27.966 -30.015 -0.494  1.00 22.88 ? 282 THR A O   1 
ATOM   230  C CB  . THR A 1 29  ? 30.005 -28.676 1.003   1.00 23.25 ? 282 THR A CB  1 
ATOM   231  O OG1 . THR A 1 29  ? 30.934 -28.651 -0.082  1.00 24.40 ? 282 THR A OG1 1 
ATOM   232  C CG2 . THR A 1 29  ? 30.617 -28.038 2.232   1.00 23.67 ? 282 THR A CG2 1 
ATOM   233  N N   . GLN A 1 30  ? 28.914 -32.027 -0.081  1.00 19.46 ? 283 GLN A N   1 
ATOM   234  C CA  . GLN A 1 30  ? 28.019 -32.772 -0.941  1.00 18.32 ? 283 GLN A CA  1 
ATOM   235  C C   . GLN A 1 30  ? 26.946 -33.429 -0.075  1.00 15.32 ? 283 GLN A C   1 
ATOM   236  O O   . GLN A 1 30  ? 27.182 -33.807 1.074   1.00 18.06 ? 283 GLN A O   1 
ATOM   237  C CB  . GLN A 1 30  ? 28.753 -33.856 -1.724  1.00 18.81 ? 283 GLN A CB  1 
ATOM   238  C CG  . GLN A 1 30  ? 29.683 -33.318 -2.797  1.00 21.29 ? 283 GLN A CG  1 
ATOM   239  C CD  . GLN A 1 30  ? 30.401 -34.438 -3.512  1.00 23.51 ? 283 GLN A CD  1 
ATOM   240  O OE1 . GLN A 1 30  ? 30.893 -35.368 -2.890  1.00 24.56 ? 283 GLN A OE1 1 
ATOM   241  N NE2 . GLN A 1 30  ? 30.519 -34.348 -4.824  1.00 25.71 ? 283 GLN A NE2 1 
ATOM   242  N N   . GLY A 1 31  ? 25.767 -33.537 -0.651  1.00 13.57 ? 284 GLY A N   1 
ATOM   243  C CA  . GLY A 1 31  ? 24.751 -34.368 -0.035  1.00 13.97 ? 284 GLY A CA  1 
ATOM   244  C C   . GLY A 1 31  ? 24.990 -35.826 -0.401  1.00 13.75 ? 284 GLY A C   1 
ATOM   245  O O   . GLY A 1 31  ? 25.460 -36.130 -1.508  1.00 14.67 ? 284 GLY A O   1 
ATOM   246  N N   . ASN A 1 32  ? 24.535 -36.732 0.464   1.00 13.24 ? 285 ASN A N   1 
ATOM   247  C CA  . ASN A 1 32  ? 24.676 -38.156 0.209   1.00 13.33 ? 285 ASN A CA  1 
ATOM   248  C C   . ASN A 1 32  ? 23.334 -38.868 0.091   1.00 13.53 ? 285 ASN A C   1 
ATOM   249  O O   . ASN A 1 32  ? 23.312 -40.101 0.015   1.00 13.98 ? 285 ASN A O   1 
ATOM   250  C CB  . ASN A 1 32  ? 25.498 -38.823 1.311   1.00 13.32 ? 285 ASN A CB  1 
ATOM   251  C CG  . ASN A 1 32  ? 24.746 -38.879 2.623   1.00 13.86 ? 285 ASN A CG  1 
ATOM   252  O OD1 . ASN A 1 32  ? 23.905 -38.027 2.882   1.00 14.02 ? 285 ASN A OD1 1 
ATOM   253  N ND2 . ASN A 1 32  ? 25.022 -39.870 3.457   1.00 15.59 ? 285 ASN A ND2 1 
ATOM   254  N N   . PHE A 1 33  ? 22.222 -38.141 0.100   1.00 12.55 ? 286 PHE A N   1 
ATOM   255  C CA  . PHE A 1 33  ? 20.912 -38.750 0.237   1.00 12.74 ? 286 PHE A CA  1 
ATOM   256  C C   . PHE A 1 33  ? 20.182 -38.749 -1.090  1.00 13.58 ? 286 PHE A C   1 
ATOM   257  O O   . PHE A 1 33  ? 20.019 -37.701 -1.718  1.00 13.65 ? 286 PHE A O   1 
ATOM   258  C CB  . PHE A 1 33  ? 20.108 -38.002 1.299   1.00 12.57 ? 286 PHE A CB  1 
ATOM   259  C CG  . PHE A 1 33  ? 18.796 -38.635 1.687   1.00 12.80 ? 286 PHE A CG  1 
ATOM   260  C CD1 . PHE A 1 33  ? 17.621 -38.343 1.020   1.00 13.49 ? 286 PHE A CD1 1 
ATOM   261  C CD2 . PHE A 1 33  ? 18.741 -39.493 2.767   1.00 13.59 ? 286 PHE A CD2 1 
ATOM   262  C CE1 . PHE A 1 33  ? 16.426 -38.907 1.428   1.00 13.48 ? 286 PHE A CE1 1 
ATOM   263  C CE2 . PHE A 1 33  ? 17.543 -40.048 3.177   1.00 13.41 ? 286 PHE A CE2 1 
ATOM   264  C CZ  . PHE A 1 33  ? 16.394 -39.755 2.507   1.00 13.57 ? 286 PHE A CZ  1 
ATOM   265  N N   . GLY A 1 34  ? 19.697 -39.945 -1.439  1.00 13.74 ? 287 GLY A N   1 
ATOM   266  C CA  . GLY A 1 34  ? 18.756 -40.085 -2.529  1.00 14.50 ? 287 GLY A CA  1 
ATOM   267  C C   . GLY A 1 34  ? 19.203 -41.142 -3.528  1.00 15.38 ? 287 GLY A C   1 
ATOM   268  O O   . GLY A 1 34  ? 20.342 -41.156 -3.961  1.00 15.74 ? 287 GLY A O   1 
ATOM   269  N N   . ASP A 1 35  ? 18.273 -42.050 -3.830  1.00 16.25 ? 288 ASP A N   1 
ATOM   270  C CA  . ASP A 1 35  ? 18.476 -42.983 -4.930  1.00 16.77 ? 288 ASP A CA  1 
ATOM   271  C C   . ASP A 1 35  ? 18.159 -42.268 -6.246  1.00 17.98 ? 288 ASP A C   1 
ATOM   272  O O   . ASP A 1 35  ? 17.849 -41.078 -6.291  1.00 17.89 ? 288 ASP A O   1 
ATOM   273  C CB  . ASP A 1 35  ? 17.670 -44.259 -4.685  1.00 18.14 ? 288 ASP A CB  1 
ATOM   274  C CG  . ASP A 1 35  ? 16.173 -44.139 -4.896  1.00 19.38 ? 288 ASP A CG  1 
ATOM   275  O OD1 . ASP A 1 35  ? 15.474 -45.168 -4.675  1.00 22.81 ? 288 ASP A OD1 1 
ATOM   276  O OD2 . ASP A 1 35  ? 15.699 -43.059 -5.271  1.00 18.22 ? 288 ASP A OD2 1 
ATOM   277  N N   . GLN A 1 36  ? 18.246 -42.997 -7.362  1.00 18.84 ? 289 GLN A N   1 
ATOM   278  C CA  . GLN A 1 36  ? 18.121 -42.352 -8.656  1.00 19.82 ? 289 GLN A CA  1 
ATOM   279  C C   . GLN A 1 36  ? 16.730 -41.762 -8.844  1.00 17.67 ? 289 GLN A C   1 
ATOM   280  O O   . GLN A 1 36  ? 16.572 -40.720 -9.458  1.00 18.16 ? 289 GLN A O   1 
ATOM   281  C CB  . GLN A 1 36  ? 18.453 -43.348 -9.767  1.00 22.17 ? 289 GLN A CB  1 
ATOM   282  C CG  . GLN A 1 36  ? 19.936 -43.667 -9.798  1.00 26.18 ? 289 GLN A CG  1 
ATOM   283  C CD  . GLN A 1 36  ? 20.692 -42.618 -10.578 1.00 33.15 ? 289 GLN A CD  1 
ATOM   284  O OE1 . GLN A 1 36  ? 20.533 -41.412 -10.380 1.00 37.31 ? 289 GLN A OE1 1 
ATOM   285  N NE2 . GLN A 1 36  ? 21.531 -43.076 -11.494 1.00 38.09 ? 289 GLN A NE2 1 
ATOM   286  N N   . GLU A 1 37  ? 15.710 -42.427 -8.306  1.00 18.62 ? 290 GLU A N   1 
ATOM   287  C CA  . GLU A 1 37  ? 14.349 -41.964 -8.479  1.00 19.87 ? 290 GLU A CA  1 
ATOM   288  C C   . GLU A 1 37  ? 14.132 -40.655 -7.716  1.00 18.30 ? 290 GLU A C   1 
ATOM   289  O O   . GLU A 1 37  ? 13.577 -39.697 -8.247  1.00 18.44 ? 290 GLU A O   1 
ATOM   290  C CB  . GLU A 1 37  ? 13.391 -43.057 -8.008  1.00 22.63 ? 290 GLU A CB  1 
ATOM   291  C CG  . GLU A 1 37  ? 11.929 -42.730 -8.227  1.00 26.04 ? 290 GLU A CG  1 
ATOM   292  C CD  . GLU A 1 37  ? 10.986 -43.823 -7.758  1.00 27.47 ? 290 GLU A CD  1 
ATOM   293  O OE1 . GLU A 1 37  ? 11.450 -44.763 -7.061  1.00 31.48 ? 290 GLU A OE1 1 
ATOM   294  O OE2 . GLU A 1 37  ? 9.786  -43.724 -8.087  1.00 33.82 ? 290 GLU A OE2 1 
ATOM   295  N N   . LEU A 1 38  ? 14.586 -40.596 -6.452  1.00 18.16 ? 291 LEU A N   1 
ATOM   296  C CA  . LEU A 1 38  ? 14.423 -39.359 -5.700  1.00 17.46 ? 291 LEU A CA  1 
ATOM   297  C C   . LEU A 1 38  ? 15.264 -38.243 -6.324  1.00 15.77 ? 291 LEU A C   1 
ATOM   298  O O   . LEU A 1 38  ? 14.817 -37.109 -6.396  1.00 16.25 ? 291 LEU A O   1 
ATOM   299  C CB  . LEU A 1 38  ? 14.790 -39.594 -4.231  1.00 17.19 ? 291 LEU A CB  1 
ATOM   300  C CG  . LEU A 1 38  ? 14.854 -38.321 -3.383  1.00 17.39 ? 291 LEU A CG  1 
ATOM   301  C CD1 . LEU A 1 38  ? 13.557 -37.541 -3.391  1.00 17.76 ? 291 LEU A CD1 1 
ATOM   302  C CD2 . LEU A 1 38  ? 15.254 -38.653 -1.961  1.00 18.46 ? 291 LEU A CD2 1 
ATOM   303  N N   . ILE A 1 39  ? 16.467 -38.569 -6.794  1.00 17.31 ? 292 ILE A N   1 
ATOM   304  C CA  . ILE A 1 39  ? 17.291 -37.541 -7.406  1.00 16.72 ? 292 ILE A CA  1 
ATOM   305  C C   . ILE A 1 39  ? 16.576 -36.900 -8.595  1.00 16.73 ? 292 ILE A C   1 
ATOM   306  O O   . ILE A 1 39  ? 16.616 -35.690 -8.764  1.00 16.87 ? 292 ILE A O   1 
ATOM   307  C CB  . ILE A 1 39  ? 18.665 -38.103 -7.800  1.00 17.81 ? 292 ILE A CB  1 
ATOM   308  C CG1 . ILE A 1 39  ? 19.499 -38.397 -6.551  1.00 17.79 ? 292 ILE A CG1 1 
ATOM   309  C CG2 . ILE A 1 39  ? 19.388 -37.181 -8.775  1.00 18.12 ? 292 ILE A CG2 1 
ATOM   310  C CD1 . ILE A 1 39  ? 20.682 -39.274 -6.834  1.00 17.92 ? 292 ILE A CD1 1 
ATOM   311  N N   . ARG A 1 40  ? 15.919 -37.724 -9.416  1.00 18.93 ? 293 ARG A N   1 
ATOM   312  C CA  . ARG A 1 40  ? 15.275 -37.268 -10.636 1.00 19.06 ? 293 ARG A CA  1 
ATOM   313  C C   . ARG A 1 40  ? 14.012 -36.463 -10.326 1.00 19.23 ? 293 ARG A C   1 
ATOM   314  O O   . ARG A 1 40  ? 13.631 -35.575 -11.092 1.00 19.77 ? 293 ARG A O   1 
ATOM   315  C CB  . ARG A 1 40  ? 14.966 -38.523 -11.467 1.00 21.39 ? 293 ARG A CB  1 
ATOM   316  C CG  . ARG A 1 40  ? 14.342 -38.284 -12.827 1.00 23.41 ? 293 ARG A CG  1 
ATOM   317  C CD  . ARG A 1 40  ? 14.201 -39.622 -13.545 1.00 23.64 ? 293 ARG A CD  1 
ATOM   318  N NE  . ARG A 1 40  ? 13.144 -40.451 -12.984 1.00 23.91 ? 293 ARG A NE  1 
ATOM   319  C CZ  . ARG A 1 40  ? 13.296 -41.660 -12.448 1.00 24.94 ? 293 ARG A CZ  1 
ATOM   320  N NH1 . ARG A 1 40  ? 14.490 -42.216 -12.328 1.00 25.70 ? 293 ARG A NH1 1 
ATOM   321  N NH2 . ARG A 1 40  ? 12.234 -42.330 -12.038 1.00 28.47 ? 293 ARG A NH2 1 
ATOM   322  N N   . GLN A 1 41  ? 13.362 -36.758 -9.188  1.00 19.37 ? 294 GLN A N   1 
ATOM   323  C CA  . GLN A 1 41  ? 12.029 -36.236 -8.937  1.00 21.06 ? 294 GLN A CA  1 
ATOM   324  C C   . GLN A 1 41  ? 11.960 -35.201 -7.813  1.00 18.93 ? 294 GLN A C   1 
ATOM   325  O O   . GLN A 1 41  ? 11.001 -34.443 -7.754  1.00 19.09 ? 294 GLN A O   1 
ATOM   326  C CB  . GLN A 1 41  ? 11.116 -37.407 -8.603  1.00 21.17 ? 294 GLN A CB  1 
ATOM   327  C CG  . GLN A 1 41  ? 10.905 -38.303 -9.810  1.00 23.67 ? 294 GLN A CG  1 
ATOM   328  C CD  . GLN A 1 41  ? 9.988  -39.457 -9.515  1.00 26.67 ? 294 GLN A CD  1 
ATOM   329  O OE1 . GLN A 1 41  ? 9.769  -39.835 -8.364  1.00 28.79 ? 294 GLN A OE1 1 
ATOM   330  N NE2 . GLN A 1 41  ? 9.457  -40.046 -10.578 1.00 27.97 ? 294 GLN A NE2 1 
ATOM   331  N N   . GLY A 1 42  ? 12.915 -35.202 -6.881  1.00 19.02 ? 295 GLY A N   1 
ATOM   332  C CA  . GLY A 1 42  ? 12.850 -34.277 -5.759  1.00 18.58 ? 295 GLY A CA  1 
ATOM   333  C C   . GLY A 1 42  ? 11.541 -34.405 -4.988  1.00 17.48 ? 295 GLY A C   1 
ATOM   334  O O   . GLY A 1 42  ? 11.114 -35.506 -4.671  1.00 17.27 ? 295 GLY A O   1 
ATOM   335  N N   . THR A 1 43  ? 10.890 -33.269 -4.748  1.00 18.14 ? 296 THR A N   1 
ATOM   336  C CA  . THR A 1 43  ? 9.654  -33.238 -3.984  1.00 18.97 ? 296 THR A CA  1 
ATOM   337  C C   . THR A 1 43  ? 8.483  -33.863 -4.743  1.00 20.20 ? 296 THR A C   1 
ATOM   338  O O   . THR A 1 43  ? 7.419  -34.038 -4.171  1.00 21.55 ? 296 THR A O   1 
ATOM   339  C CB  . THR A 1 43  ? 9.320  -31.818 -3.524  1.00 19.28 ? 296 THR A CB  1 
ATOM   340  O OG1 . THR A 1 43  ? 9.118  -31.010 -4.683  1.00 20.44 ? 296 THR A OG1 1 
ATOM   341  C CG2 . THR A 1 43  ? 10.403 -31.218 -2.651  1.00 18.93 ? 296 THR A CG2 1 
ATOM   342  N N   . ASP A 1 44  ? 8.669  -34.210 -6.021  1.00 20.06 ? 297 ASP A N   1 
ATOM   343  C CA  . ASP A 1 44  ? 7.663  -34.939 -6.785  1.00 21.38 ? 297 ASP A CA  1 
ATOM   344  C C   . ASP A 1 44  ? 7.755  -36.448 -6.536  1.00 21.04 ? 297 ASP A C   1 
ATOM   345  O O   . ASP A 1 44  ? 6.905  -37.213 -6.988  1.00 24.70 ? 297 ASP A O   1 
ATOM   346  C CB  . ASP A 1 44  ? 7.782  -34.635 -8.283  1.00 23.03 ? 297 ASP A CB  1 
ATOM   347  C CG  . ASP A 1 44  ? 7.447  -33.200 -8.663  1.00 23.24 ? 297 ASP A CG  1 
ATOM   348  O OD1 . ASP A 1 44  ? 8.171  -32.605 -9.492  1.00 24.49 ? 297 ASP A OD1 1 
ATOM   349  O OD2 . ASP A 1 44  ? 6.482  -32.662 -8.089  1.00 27.27 ? 297 ASP A OD2 1 
ATOM   350  N N   . TYR A 1 45  ? 8.788  -36.902 -5.825  1.00 19.38 ? 298 TYR A N   1 
ATOM   351  C CA  . TYR A 1 45  ? 8.932  -38.306 -5.474  1.00 19.29 ? 298 TYR A CA  1 
ATOM   352  C C   . TYR A 1 45  ? 7.715  -38.794 -4.694  1.00 19.75 ? 298 TYR A C   1 
ATOM   353  O O   . TYR A 1 45  ? 7.234  -38.105 -3.810  1.00 20.67 ? 298 TYR A O   1 
ATOM   354  C CB  . TYR A 1 45  ? 10.199 -38.463 -4.634  1.00 19.62 ? 298 TYR A CB  1 
ATOM   355  C CG  . TYR A 1 45  ? 10.573 -39.844 -4.168  1.00 20.04 ? 298 TYR A CG  1 
ATOM   356  C CD1 . TYR A 1 45  ? 10.674 -40.123 -2.807  1.00 19.58 ? 298 TYR A CD1 1 
ATOM   357  C CD2 . TYR A 1 45  ? 10.886 -40.863 -5.060  1.00 20.91 ? 298 TYR A CD2 1 
ATOM   358  C CE1 . TYR A 1 45  ? 11.085 -41.368 -2.358  1.00 20.20 ? 298 TYR A CE1 1 
ATOM   359  C CE2 . TYR A 1 45  ? 11.269 -42.116 -4.620  1.00 21.12 ? 298 TYR A CE2 1 
ATOM   360  C CZ  . TYR A 1 45  ? 11.335 -42.384 -3.264  1.00 20.50 ? 298 TYR A CZ  1 
ATOM   361  O OH  . TYR A 1 45  ? 11.748 -43.606 -2.796  1.00 21.58 ? 298 TYR A OH  1 
ATOM   362  N N   . LYS A 1 46  ? 7.255  -40.009 -5.006  1.00 20.55 ? 299 LYS A N   1 
ATOM   363  C CA  . LYS A 1 46  ? 6.039  -40.571 -4.444  1.00 22.89 ? 299 LYS A CA  1 
ATOM   364  C C   . LYS A 1 46  ? 6.061  -40.629 -2.919  1.00 22.23 ? 299 LYS A C   1 
ATOM   365  O O   . LYS A 1 46  ? 5.036  -40.422 -2.272  1.00 24.21 ? 299 LYS A O   1 
ATOM   366  C CB  . LYS A 1 46  ? 5.801  -41.982 -4.995  1.00 27.09 ? 299 LYS A CB  1 
ATOM   367  C CG  . LYS A 1 46  ? 6.925  -43.000 -4.788  1.00 31.14 ? 299 LYS A CG  1 
ATOM   368  C CD  . LYS A 1 46  ? 6.618  -44.391 -5.330  1.00 35.36 ? 299 LYS A CD  1 
ATOM   369  C CE  . LYS A 1 46  ? 7.846  -45.152 -5.790  1.00 38.78 ? 299 LYS A CE  1 
ATOM   370  N NZ  . LYS A 1 46  ? 8.838  -45.310 -4.703  1.00 41.42 ? 299 LYS A NZ  1 
ATOM   371  N N   . HIS A 1 47  ? 7.223  -40.920 -2.337  1.00 20.41 ? 300 HIS A N   1 
ATOM   372  C CA  . HIS A 1 47  ? 7.316  -41.030 -0.884  1.00 21.31 ? 300 HIS A CA  1 
ATOM   373  C C   . HIS A 1 47  ? 7.960  -39.785 -0.285  1.00 19.49 ? 300 HIS A C   1 
ATOM   374  O O   . HIS A 1 47  ? 8.412  -39.832 0.850   1.00 19.80 ? 300 HIS A O   1 
ATOM   375  C CB  . HIS A 1 47  ? 8.064  -42.308 -0.481  1.00 23.04 ? 300 HIS A CB  1 
ATOM   376  C CG  . HIS A 1 47  ? 7.353  -43.522 -0.974  1.00 28.12 ? 300 HIS A CG  1 
ATOM   377  N ND1 . HIS A 1 47  ? 5.999  -43.754 -0.830  1.00 30.84 ? 300 HIS A ND1 1 
ATOM   378  C CD2 . HIS A 1 47  ? 7.832  -44.563 -1.644  1.00 31.35 ? 300 HIS A CD2 1 
ATOM   379  C CE1 . HIS A 1 47  ? 5.691  -44.901 -1.407  1.00 31.17 ? 300 HIS A CE1 1 
ATOM   380  N NE2 . HIS A 1 47  ? 6.792  -45.427 -1.882  1.00 32.02 ? 300 HIS A NE2 1 
ATOM   381  N N   . TRP A 1 48  ? 7.941  -38.663 -0.993  1.00 18.46 ? 301 TRP A N   1 
ATOM   382  C CA  . TRP A 1 48  ? 8.559  -37.465 -0.456  1.00 18.07 ? 301 TRP A CA  1 
ATOM   383  C C   . TRP A 1 48  ? 7.960  -37.106 0.909   1.00 18.62 ? 301 TRP A C   1 
ATOM   384  O O   . TRP A 1 48  ? 8.702  -36.766 1.833   1.00 17.90 ? 301 TRP A O   1 
ATOM   385  C CB  . TRP A 1 48  ? 8.504  -36.290 -1.431  1.00 18.70 ? 301 TRP A CB  1 
ATOM   386  C CG  . TRP A 1 48  ? 9.097  -35.066 -0.804  1.00 17.05 ? 301 TRP A CG  1 
ATOM   387  C CD1 . TRP A 1 48  ? 8.432  -33.958 -0.375  1.00 18.01 ? 301 TRP A CD1 1 
ATOM   388  C CD2 . TRP A 1 48  ? 10.475 -34.890 -0.431  1.00 16.38 ? 301 TRP A CD2 1 
ATOM   389  N NE1 . TRP A 1 48  ? 9.301  -33.093 0.237   1.00 17.24 ? 301 TRP A NE1 1 
ATOM   390  C CE2 . TRP A 1 48  ? 10.553 -33.637 0.206   1.00 16.15 ? 301 TRP A CE2 1 
ATOM   391  C CE3 . TRP A 1 48  ? 11.630 -35.658 -0.592  1.00 16.17 ? 301 TRP A CE3 1 
ATOM   392  C CZ2 . TRP A 1 48  ? 11.756 -33.144 0.704   1.00 16.18 ? 301 TRP A CZ2 1 
ATOM   393  C CZ3 . TRP A 1 48  ? 12.821 -35.158 -0.131  1.00 17.73 ? 301 TRP A CZ3 1 
ATOM   394  C CH2 . TRP A 1 48  ? 12.870 -33.931 0.530   1.00 17.37 ? 301 TRP A CH2 1 
ATOM   395  N N   . PRO A 1 49  ? 6.632  -37.136 1.133   1.00 18.44 ? 302 PRO A N   1 
ATOM   396  C CA  . PRO A 1 49  ? 6.099  -36.752 2.440   1.00 19.04 ? 302 PRO A CA  1 
ATOM   397  C C   . PRO A 1 49  ? 6.667  -37.557 3.600   1.00 18.23 ? 302 PRO A C   1 
ATOM   398  O O   . PRO A 1 49  ? 6.845  -37.018 4.689   1.00 18.67 ? 302 PRO A O   1 
ATOM   399  C CB  . PRO A 1 49  ? 4.590  -36.969 2.296   1.00 20.25 ? 302 PRO A CB  1 
ATOM   400  C CG  . PRO A 1 49  ? 4.373  -36.743 0.826   1.00 20.70 ? 302 PRO A CG  1 
ATOM   401  C CD  . PRO A 1 49  ? 5.569  -37.393 0.146   1.00 19.74 ? 302 PRO A CD  1 
ATOM   402  N N   . GLN A 1 50  ? 6.987  -38.823 3.361   1.00 17.58 ? 303 GLN A N   1 
ATOM   403  C CA  . GLN A 1 50  ? 7.481  -39.705 4.400   1.00 17.78 ? 303 GLN A CA  1 
ATOM   404  C C   . GLN A 1 50  ? 8.951  -39.401 4.708   1.00 16.60 ? 303 GLN A C   1 
ATOM   405  O O   . GLN A 1 50  ? 9.448  -39.810 5.750   1.00 18.25 ? 303 GLN A O   1 
ATOM   406  C CB  . GLN A 1 50  ? 7.298  -41.174 4.003   1.00 19.66 ? 303 GLN A CB  1 
ATOM   407  C CG  . GLN A 1 50  ? 5.849  -41.645 3.970   1.00 22.96 ? 303 GLN A CG  1 
ATOM   408  C CD  . GLN A 1 50  ? 4.998  -41.025 2.884   1.00 27.10 ? 303 GLN A CD  1 
ATOM   409  O OE1 . GLN A 1 50  ? 5.389  -40.904 1.726   1.00 26.95 ? 303 GLN A OE1 1 
ATOM   410  N NE2 . GLN A 1 50  ? 3.824  -40.558 3.268   1.00 33.19 ? 303 GLN A NE2 1 
ATOM   411  N N   . ILE A 1 51  ? 9.641  -38.713 3.787   1.00 15.76 ? 304 ILE A N   1 
ATOM   412  C CA  . ILE A 1 51  ? 10.983 -38.201 4.033   1.00 15.56 ? 304 ILE A CA  1 
ATOM   413  C C   . ILE A 1 51  ? 10.880 -36.845 4.721   1.00 14.69 ? 304 ILE A C   1 
ATOM   414  O O   . ILE A 1 51  ? 11.551 -36.603 5.728   1.00 15.52 ? 304 ILE A O   1 
ATOM   415  C CB  . ILE A 1 51  ? 11.769 -38.127 2.711   1.00 16.92 ? 304 ILE A CB  1 
ATOM   416  C CG1 . ILE A 1 51  ? 11.932 -39.521 2.097   1.00 18.19 ? 304 ILE A CG1 1 
ATOM   417  C CG2 . ILE A 1 51  ? 13.101 -37.417 2.928   1.00 17.58 ? 304 ILE A CG2 1 
ATOM   418  C CD1 . ILE A 1 51  ? 12.431 -39.521 0.672   1.00 18.31 ? 304 ILE A CD1 1 
ATOM   419  N N   . ALA A 1 52  ? 10.051 -35.967 4.176   1.00 15.21 ? 305 ALA A N   1 
ATOM   420  C CA  . ALA A 1 52  ? 9.948  -34.600 4.667   1.00 14.95 ? 305 ALA A CA  1 
ATOM   421  C C   . ALA A 1 52  ? 9.493  -34.540 6.123   1.00 14.92 ? 305 ALA A C   1 
ATOM   422  O O   . ALA A 1 52  ? 9.775  -33.551 6.795   1.00 15.27 ? 305 ALA A O   1 
ATOM   423  C CB  . ALA A 1 52  ? 9.028  -33.783 3.798   1.00 15.96 ? 305 ALA A CB  1 
ATOM   424  N N   . GLN A 1 53  ? 8.825  -35.583 6.628   1.00 14.36 ? 306 GLN A N   1 
ATOM   425  C CA  . GLN A 1 53  ? 8.376  -35.583 8.007   1.00 14.73 ? 306 GLN A CA  1 
ATOM   426  C C   . GLN A 1 53  ? 9.562  -35.492 8.965   1.00 14.57 ? 306 GLN A C   1 
ATOM   427  O O   . GLN A 1 53  ? 9.387  -35.152 10.135  1.00 14.97 ? 306 GLN A O   1 
ATOM   428  C CB  . GLN A 1 53  ? 7.540  -36.823 8.302   1.00 16.10 ? 306 GLN A CB  1 
ATOM   429  C CG  . GLN A 1 53  ? 8.348  -38.097 8.486   1.00 16.66 ? 306 GLN A CG  1 
ATOM   430  C CD  . GLN A 1 53  ? 7.418  -39.270 8.669   1.00 18.22 ? 306 GLN A CD  1 
ATOM   431  O OE1 . GLN A 1 53  ? 6.521  -39.246 9.511   1.00 19.47 ? 306 GLN A OE1 1 
ATOM   432  N NE2 . GLN A 1 53  ? 7.580  -40.293 7.848   1.00 17.79 ? 306 GLN A NE2 1 
ATOM   433  N N   . PHE A 1 54  ? 10.763 -35.805 8.490   1.00 13.72 ? 307 PHE A N   1 
ATOM   434  C CA  . PHE A 1 54  ? 11.956 -35.731 9.318   1.00 13.64 ? 307 PHE A CA  1 
ATOM   435  C C   . PHE A 1 54  ? 12.694 -34.410 9.168   1.00 13.65 ? 307 PHE A C   1 
ATOM   436  O O   . PHE A 1 54  ? 13.618 -34.162 9.937   1.00 15.09 ? 307 PHE A O   1 
ATOM   437  C CB  . PHE A 1 54  ? 12.879 -36.900 8.993   1.00 14.17 ? 307 PHE A CB  1 
ATOM   438  C CG  . PHE A 1 54  ? 12.235 -38.209 9.324   1.00 14.75 ? 307 PHE A CG  1 
ATOM   439  C CD1 . PHE A 1 54  ? 11.919 -38.514 10.638  1.00 16.24 ? 307 PHE A CD1 1 
ATOM   440  C CD2 . PHE A 1 54  ? 11.851 -39.084 8.320   1.00 15.88 ? 307 PHE A CD2 1 
ATOM   441  C CE1 . PHE A 1 54  ? 11.257 -39.696 10.936  1.00 17.75 ? 307 PHE A CE1 1 
ATOM   442  C CE2 . PHE A 1 54  ? 11.214 -40.271 8.632   1.00 17.16 ? 307 PHE A CE2 1 
ATOM   443  C CZ  . PHE A 1 54  ? 10.914 -40.569 9.926   1.00 18.22 ? 307 PHE A CZ  1 
ATOM   444  N N   . ALA A 1 55  ? 12.360 -33.607 8.158   1.00 13.54 ? 308 ALA A N   1 
ATOM   445  C CA  . ALA A 1 55  ? 13.064 -32.356 7.969   1.00 13.43 ? 308 ALA A CA  1 
ATOM   446  C C   . ALA A 1 55  ? 12.621 -31.361 9.026   1.00 13.84 ? 308 ALA A C   1 
ATOM   447  O O   . ALA A 1 55  ? 11.447 -31.267 9.360   1.00 14.40 ? 308 ALA A O   1 
ATOM   448  C CB  . ALA A 1 55  ? 12.800 -31.804 6.599   1.00 13.48 ? 308 ALA A CB  1 
ATOM   449  N N   . PRO A 1 56  ? 13.555 -30.569 9.571   1.00 12.64 ? 309 PRO A N   1 
ATOM   450  C CA  . PRO A 1 56  ? 13.188 -29.622 10.623  1.00 12.65 ? 309 PRO A CA  1 
ATOM   451  C C   . PRO A 1 56  ? 12.546 -28.339 10.115  1.00 13.19 ? 309 PRO A C   1 
ATOM   452  O O   . PRO A 1 56  ? 12.916 -27.795 9.073   1.00 13.50 ? 309 PRO A O   1 
ATOM   453  C CB  . PRO A 1 56  ? 14.541 -29.331 11.259  1.00 12.95 ? 309 PRO A CB  1 
ATOM   454  C CG  . PRO A 1 56  ? 15.521 -29.457 10.105  1.00 13.36 ? 309 PRO A CG  1 
ATOM   455  C CD  . PRO A 1 56  ? 15.007 -30.659 9.347   1.00 13.54 ? 309 PRO A CD  1 
ATOM   456  N N   . SER A 1 57  ? 11.624 -27.810 10.919  1.00 12.99 ? 310 SER A N   1 
ATOM   457  C CA  . SER A 1 57  ? 11.164 -26.442 10.777  1.00 12.83 ? 310 SER A CA  1 
ATOM   458  C C   . SER A 1 57  ? 12.364 -25.515 10.935  1.00 12.40 ? 310 SER A C   1 
ATOM   459  O O   . SER A 1 57  ? 13.389 -25.907 11.479  1.00 11.91 ? 310 SER A O   1 
ATOM   460  C CB  . SER A 1 57  ? 10.122 -26.124 11.799  1.00 13.45 ? 310 SER A CB  1 
ATOM   461  O OG  . SER A 1 57  ? 10.724 -26.122 13.077  1.00 13.38 ? 310 SER A OG  1 
ATOM   462  N N   . ALA A 1 58  ? 12.231 -24.256 10.519  1.00 12.56 ? 311 ALA A N   1 
ATOM   463  C CA  . ALA A 1 58  ? 13.313 -23.313 10.710  1.00 12.69 ? 311 ALA A CA  1 
ATOM   464  C C   . ALA A 1 58  ? 13.641 -23.170 12.196  1.00 11.52 ? 311 ALA A C   1 
ATOM   465  O O   . ALA A 1 58  ? 14.796 -23.120 12.588  1.00 12.42 ? 311 ALA A O   1 
ATOM   466  C CB  . ALA A 1 58  ? 12.959 -21.979 10.103  1.00 13.21 ? 311 ALA A CB  1 
ATOM   467  N N   . SER A 1 59  ? 12.608 -23.096 13.032  1.00 11.84 ? 312 SER A N   1 
ATOM   468  C CA  . SER A 1 59  ? 12.784 -22.988 14.467  1.00 11.91 ? 312 SER A CA  1 
ATOM   469  C C   . SER A 1 59  ? 13.540 -24.206 15.008  1.00 11.13 ? 312 SER A C   1 
ATOM   470  O O   . SER A 1 59  ? 14.463 -24.081 15.792  1.00 11.51 ? 312 SER A O   1 
ATOM   471  C CB  . SER A 1 59  ? 11.418 -22.833 15.081  1.00 12.26 ? 312 SER A CB  1 
ATOM   472  O OG  . SER A 1 59  ? 11.493 -22.633 16.481  1.00 12.19 ? 312 SER A OG  1 
ATOM   473  N N   . ALA A 1 60  ? 13.141 -25.403 14.575  1.00 11.60 ? 313 ALA A N   1 
ATOM   474  C CA  . ALA A 1 60  ? 13.786 -26.614 15.052  1.00 11.94 ? 313 ALA A CA  1 
ATOM   475  C C   . ALA A 1 60  ? 15.207 -26.734 14.500  1.00 11.32 ? 313 ALA A C   1 
ATOM   476  O O   . ALA A 1 60  ? 16.102 -27.245 15.170  1.00 11.59 ? 313 ALA A O   1 
ATOM   477  C CB  . ALA A 1 60  ? 12.983 -27.838 14.696  1.00 12.35 ? 313 ALA A CB  1 
ATOM   478  N N   . PHE A 1 61  ? 15.435 -26.282 13.268  1.00 11.49 ? 314 PHE A N   1 
ATOM   479  C CA  . PHE A 1 61  ? 16.770 -26.326 12.705  1.00 10.91 ? 314 PHE A CA  1 
ATOM   480  C C   . PHE A 1 61  ? 17.725 -25.547 13.603  1.00 11.19 ? 314 PHE A C   1 
ATOM   481  O O   . PHE A 1 61  ? 18.794 -26.013 13.959  1.00 11.47 ? 314 PHE A O   1 
ATOM   482  C CB  . PHE A 1 61  ? 16.750 -25.757 11.286  1.00 11.52 ? 314 PHE A CB  1 
ATOM   483  C CG  . PHE A 1 61  ? 18.097 -25.675 10.630  1.00 12.37 ? 314 PHE A CG  1 
ATOM   484  C CD1 . PHE A 1 61  ? 18.683 -26.806 10.094  1.00 12.63 ? 314 PHE A CD1 1 
ATOM   485  C CD2 . PHE A 1 61  ? 18.786 -24.480 10.586  1.00 12.75 ? 314 PHE A CD2 1 
ATOM   486  C CE1 . PHE A 1 61  ? 19.915 -26.716 9.475   1.00 13.93 ? 314 PHE A CE1 1 
ATOM   487  C CE2 . PHE A 1 61  ? 20.032 -24.402 9.997   1.00 13.19 ? 314 PHE A CE2 1 
ATOM   488  C CZ  . PHE A 1 61  ? 20.591 -25.524 9.438   1.00 13.81 ? 314 PHE A CZ  1 
ATOM   489  N N   . PHE A 1 62  ? 17.327 -24.331 13.984  1.00 10.97 ? 315 PHE A N   1 
ATOM   490  C CA  . PHE A 1 62  ? 18.172 -23.511 14.844  1.00 11.05 ? 315 PHE A CA  1 
ATOM   491  C C   . PHE A 1 62  ? 18.069 -23.888 16.321  1.00 11.17 ? 315 PHE A C   1 
ATOM   492  O O   . PHE A 1 62  ? 18.942 -23.517 17.089  1.00 12.75 ? 315 PHE A O   1 
ATOM   493  C CB  . PHE A 1 62  ? 17.872 -22.026 14.635  1.00 11.25 ? 315 PHE A CB  1 
ATOM   494  C CG  . PHE A 1 62  ? 18.594 -21.501 13.425  1.00 11.56 ? 315 PHE A CG  1 
ATOM   495  C CD1 . PHE A 1 62  ? 17.937 -21.314 12.224  1.00 12.47 ? 315 PHE A CD1 1 
ATOM   496  C CD2 . PHE A 1 62  ? 19.944 -21.237 13.503  1.00 12.51 ? 315 PHE A CD2 1 
ATOM   497  C CE1 . PHE A 1 62  ? 18.631 -20.860 11.106  1.00 12.63 ? 315 PHE A CE1 1 
ATOM   498  C CE2 . PHE A 1 62  ? 20.636 -20.786 12.390  1.00 12.94 ? 315 PHE A CE2 1 
ATOM   499  C CZ  . PHE A 1 62  ? 19.971 -20.595 11.203  1.00 13.51 ? 315 PHE A CZ  1 
ATOM   500  N N   . GLY A 1 63  ? 17.028 -24.626 16.708  1.00 10.90 ? 316 GLY A N   1 
ATOM   501  C CA  . GLY A 1 63  ? 16.835 -25.022 18.088  1.00 12.00 ? 316 GLY A CA  1 
ATOM   502  C C   . GLY A 1 63  ? 17.533 -26.325 18.449  1.00 12.35 ? 316 GLY A C   1 
ATOM   503  O O   . GLY A 1 63  ? 18.022 -26.480 19.557  1.00 12.93 ? 316 GLY A O   1 
ATOM   504  N N   A MET A 1 64  ? 17.543 -27.277 17.515  0.50 12.10 ? 317 MET A N   1 
ATOM   505  N N   B MET A 1 64  ? 17.543 -27.277 17.515  0.50 12.14 ? 317 MET A N   1 
ATOM   506  C CA  A MET A 1 64  ? 18.042 -28.615 17.794  0.50 12.92 ? 317 MET A CA  1 
ATOM   507  C CA  B MET A 1 64  ? 18.041 -28.615 17.792  0.50 13.00 ? 317 MET A CA  1 
ATOM   508  C C   A MET A 1 64  ? 19.517 -28.756 17.436  0.50 12.67 ? 317 MET A C   1 
ATOM   509  C C   B MET A 1 64  ? 19.516 -28.757 17.434  0.50 12.71 ? 317 MET A C   1 
ATOM   510  O O   A MET A 1 64  ? 20.216 -29.593 18.004  0.50 14.46 ? 317 MET A O   1 
ATOM   511  O O   B MET A 1 64  ? 20.213 -29.597 17.998  0.50 14.47 ? 317 MET A O   1 
ATOM   512  C CB  A MET A 1 64  ? 17.296 -29.649 16.960  0.50 13.46 ? 317 MET A CB  1 
ATOM   513  C CB  B MET A 1 64  ? 17.294 -29.647 16.956  0.50 13.65 ? 317 MET A CB  1 
ATOM   514  C CG  A MET A 1 64  ? 15.842 -29.758 17.317  0.50 13.60 ? 317 MET A CG  1 
ATOM   515  C CG  B MET A 1 64  ? 15.846 -29.767 17.328  0.50 13.89 ? 317 MET A CG  1 
ATOM   516  S SD  A MET A 1 64  ? 15.022 -31.055 16.350  0.50 15.41 ? 317 MET A SD  1 
ATOM   517  S SD  B MET A 1 64  ? 15.017 -31.058 16.361  0.50 15.84 ? 317 MET A SD  1 
ATOM   518  C CE  A MET A 1 64  ? 15.714 -30.736 14.725  0.50 14.80 ? 317 MET A CE  1 
ATOM   519  C CE  B MET A 1 64  ? 15.769 -32.539 17.032  0.50 16.30 ? 317 MET A CE  1 
ATOM   520  N N   . SER A 1 65  ? 19.974 -27.986 16.448  1.00 12.35 ? 318 SER A N   1 
ATOM   521  C CA  . SER A 1 65  ? 21.273 -28.212 15.843  1.00 12.24 ? 318 SER A CA  1 
ATOM   522  C C   . SER A 1 65  ? 22.408 -27.606 16.661  1.00 12.32 ? 318 SER A C   1 
ATOM   523  O O   . SER A 1 65  ? 22.221 -26.615 17.378  1.00 13.23 ? 318 SER A O   1 
ATOM   524  C CB  . SER A 1 65  ? 21.339 -27.653 14.450  1.00 13.18 ? 318 SER A CB  1 
ATOM   525  O OG  . SER A 1 65  ? 20.310 -28.128 13.621  1.00 13.56 ? 318 SER A OG  1 
ATOM   526  N N   . ARG A 1 66  ? 23.607 -28.150 16.454  1.00 12.49 ? 319 ARG A N   1 
ATOM   527  C CA  . ARG A 1 66  ? 24.813 -27.440 16.824  1.00 12.73 ? 319 ARG A CA  1 
ATOM   528  C C   . ARG A 1 66  ? 25.204 -26.587 15.632  1.00 12.57 ? 319 ARG A C   1 
ATOM   529  O O   . ARG A 1 66  ? 25.419 -27.120 14.535  1.00 12.94 ? 319 ARG A O   1 
ATOM   530  C CB  . ARG A 1 66  ? 25.914 -28.399 17.268  1.00 14.22 ? 319 ARG A CB  1 
ATOM   531  C CG  . ARG A 1 66  ? 25.518 -29.130 18.540  1.00 16.94 ? 319 ARG A CG  1 
ATOM   532  C CD  . ARG A 1 66  ? 26.657 -29.732 19.306  1.00 17.73 ? 319 ARG A CD  1 
ATOM   533  N NE  . ARG A 1 66  ? 27.539 -28.695 19.794  1.00 16.17 ? 319 ARG A NE  1 
ATOM   534  C CZ  . ARG A 1 66  ? 27.300 -27.905 20.827  1.00 16.31 ? 319 ARG A CZ  1 
ATOM   535  N NH1 . ARG A 1 66  ? 28.191 -26.986 21.132  1.00 17.09 ? 319 ARG A NH1 1 
ATOM   536  N NH2 . ARG A 1 66  ? 26.203 -28.028 21.562  1.00 15.59 ? 319 ARG A NH2 1 
ATOM   537  N N   . ILE A 1 67  ? 25.199 -25.269 15.838  1.00 12.58 ? 320 ILE A N   1 
ATOM   538  C CA  . ILE A 1 67  ? 25.455 -24.301 14.792  1.00 13.19 ? 320 ILE A CA  1 
ATOM   539  C C   . ILE A 1 67  ? 26.858 -23.747 14.991  1.00 12.91 ? 320 ILE A C   1 
ATOM   540  O O   . ILE A 1 67  ? 27.276 -23.459 16.118  1.00 14.07 ? 320 ILE A O   1 
ATOM   541  C CB  . ILE A 1 67  ? 24.410 -23.174 14.846  1.00 13.32 ? 320 ILE A CB  1 
ATOM   542  C CG1 . ILE A 1 67  ? 22.983 -23.709 14.686  1.00 13.49 ? 320 ILE A CG1 1 
ATOM   543  C CG2 . ILE A 1 67  ? 24.733 -22.097 13.820  1.00 13.45 ? 320 ILE A CG2 1 
ATOM   544  C CD1 . ILE A 1 67  ? 22.694 -24.304 13.327  1.00 13.26 ? 320 ILE A CD1 1 
ATOM   545  N N   . GLY A 1 68  ? 27.572 -23.557 13.891  1.00 12.55 ? 321 GLY A N   1 
ATOM   546  C CA  . GLY A 1 68  ? 28.847 -22.874 13.928  1.00 13.56 ? 321 GLY A CA  1 
ATOM   547  C C   . GLY A 1 68  ? 29.041 -22.031 12.689  1.00 13.79 ? 321 GLY A C   1 
ATOM   548  O O   . GLY A 1 68  ? 28.201 -21.972 11.814  1.00 12.91 ? 321 GLY A O   1 
ATOM   549  N N   . MET A 1 69  ? 30.129 -21.271 12.718  1.00 15.30 ? 322 MET A N   1 
ATOM   550  C CA  . MET A 1 69  ? 30.505 -20.426 11.598  1.00 16.79 ? 322 MET A CA  1 
ATOM   551  C C   . MET A 1 69  ? 31.975 -20.677 11.310  1.00 17.54 ? 322 MET A C   1 
ATOM   552  O O   . MET A 1 69  ? 32.797 -20.650 12.228  1.00 19.24 ? 322 MET A O   1 
ATOM   553  C CB  . MET A 1 69  ? 30.299 -18.954 11.954  1.00 19.24 ? 322 MET A CB  1 
ATOM   554  C CG  . MET A 1 69  ? 28.860 -18.603 12.097  1.00 21.31 ? 322 MET A CG  1 
ATOM   555  S SD  . MET A 1 69  ? 28.074 -18.364 10.514  1.00 24.68 ? 322 MET A SD  1 
ATOM   556  C CE  . MET A 1 69  ? 28.541 -16.659 10.266  1.00 22.84 ? 322 MET A CE  1 
ATOM   557  N N   . GLU A 1 70  ? 32.279 -20.952 10.043  1.00 17.82 ? 323 GLU A N   1 
ATOM   558  C CA  . GLU A 1 70  ? 33.646 -21.234 9.633   1.00 18.68 ? 323 GLU A CA  1 
ATOM   559  C C   . GLU A 1 70  ? 34.015 -20.303 8.491   1.00 17.79 ? 323 GLU A C   1 
ATOM   560  O O   . GLU A 1 70  ? 33.297 -20.224 7.499   1.00 17.99 ? 323 GLU A O   1 
ATOM   561  C CB  . GLU A 1 70  ? 33.789 -22.687 9.191   1.00 19.70 ? 323 GLU A CB  1 
ATOM   562  C CG  . GLU A 1 70  ? 33.523 -23.689 10.295  1.00 21.48 ? 323 GLU A CG  1 
ATOM   563  C CD  . GLU A 1 70  ? 34.459 -23.640 11.488  1.00 24.74 ? 323 GLU A CD  1 
ATOM   564  O OE1 . GLU A 1 70  ? 34.061 -24.114 12.573  1.00 25.54 ? 323 GLU A OE1 1 
ATOM   565  O OE2 . GLU A 1 70  ? 35.577 -23.115 11.335  1.00 26.15 ? 323 GLU A OE2 1 
ATOM   566  N N   . VAL A 1 71  ? 35.169 -19.658 8.653   1.00 18.75 ? 324 VAL A N   1 
ATOM   567  C CA  . VAL A 1 71  ? 35.796 -18.918 7.580   1.00 19.55 ? 324 VAL A CA  1 
ATOM   568  C C   . VAL A 1 71  ? 36.782 -19.853 6.888   1.00 19.68 ? 324 VAL A C   1 
ATOM   569  O O   . VAL A 1 71  ? 37.601 -20.504 7.532   1.00 21.52 ? 324 VAL A O   1 
ATOM   570  C CB  . VAL A 1 71  ? 36.477 -17.662 8.139   1.00 22.22 ? 324 VAL A CB  1 
ATOM   571  C CG1 . VAL A 1 71  ? 37.279 -16.911 7.074   1.00 24.69 ? 324 VAL A CG1 1 
ATOM   572  C CG2 . VAL A 1 71  ? 35.475 -16.739 8.800   1.00 24.94 ? 324 VAL A CG2 1 
ATOM   573  N N   . THR A 1 72  ? 36.607 -19.982 5.577   1.00 19.59 ? 325 THR A N   1 
ATOM   574  C CA  . THR A 1 72  ? 37.400 -20.896 4.791   1.00 21.18 ? 325 THR A CA  1 
ATOM   575  C C   . THR A 1 72  ? 37.894 -20.099 3.600   1.00 20.78 ? 325 THR A C   1 
ATOM   576  O O   . THR A 1 72  ? 37.468 -18.961 3.381   1.00 20.02 ? 325 THR A O   1 
ATOM   577  C CB  . THR A 1 72  ? 36.594 -22.128 4.361   1.00 20.53 ? 325 THR A CB  1 
ATOM   578  O OG1 . THR A 1 72  ? 35.824 -21.743 3.209   1.00 21.54 ? 325 THR A OG1 1 
ATOM   579  C CG2 . THR A 1 72  ? 35.736 -22.678 5.480   1.00 21.23 ? 325 THR A CG2 1 
ATOM   580  N N   . PRO A 1 73  ? 38.789 -20.672 2.772   1.00 23.15 ? 326 PRO A N   1 
ATOM   581  C CA  . PRO A 1 73  ? 39.253 -19.951 1.591   1.00 24.16 ? 326 PRO A CA  1 
ATOM   582  C C   . PRO A 1 73  ? 38.140 -19.401 0.698   1.00 22.94 ? 326 PRO A C   1 
ATOM   583  O O   . PRO A 1 73  ? 38.296 -18.337 0.124   1.00 23.70 ? 326 PRO A O   1 
ATOM   584  C CB  . PRO A 1 73  ? 40.118 -21.004 0.889   1.00 24.53 ? 326 PRO A CB  1 
ATOM   585  C CG  . PRO A 1 73  ? 40.644 -21.850 2.021   1.00 24.53 ? 326 PRO A CG  1 
ATOM   586  C CD  . PRO A 1 73  ? 39.471 -21.954 2.969   1.00 23.64 ? 326 PRO A CD  1 
ATOM   587  N N   . SER A 1 74  ? 36.990 -20.082 0.626   1.00 20.02 ? 327 SER A N   1 
ATOM   588  C CA  . SER A 1 74  ? 35.953 -19.675 -0.306  1.00 18.40 ? 327 SER A CA  1 
ATOM   589  C C   . SER A 1 74  ? 34.975 -18.684 0.316   1.00 18.22 ? 327 SER A C   1 
ATOM   590  O O   . SER A 1 74  ? 34.225 -18.050 -0.408  1.00 20.66 ? 327 SER A O   1 
ATOM   591  C CB  . SER A 1 74  ? 35.213 -20.865 -0.843  1.00 18.22 ? 327 SER A CB  1 
ATOM   592  O OG  . SER A 1 74  ? 34.567 -21.566 0.218   1.00 17.31 ? 327 SER A OG  1 
ATOM   593  N N   . GLY A 1 75  ? 34.954 -18.563 1.640   1.00 17.26 ? 328 GLY A N   1 
ATOM   594  C CA  . GLY A 1 75  ? 34.020 -17.640 2.262   1.00 17.42 ? 328 GLY A CA  1 
ATOM   595  C C   . GLY A 1 75  ? 33.657 -18.072 3.669   1.00 16.08 ? 328 GLY A C   1 
ATOM   596  O O   . GLY A 1 75  ? 34.440 -18.718 4.321   1.00 16.95 ? 328 GLY A O   1 
ATOM   597  N N   . THR A 1 76  ? 32.498 -17.595 4.126   1.00 16.22 ? 329 THR A N   1 
ATOM   598  C CA  . THR A 1 76  ? 32.014 -17.868 5.456   1.00 16.98 ? 329 THR A CA  1 
ATOM   599  C C   . THR A 1 76  ? 30.827 -18.806 5.329   1.00 15.51 ? 329 THR A C   1 
ATOM   600  O O   . THR A 1 76  ? 29.896 -18.541 4.582   1.00 16.21 ? 329 THR A O   1 
ATOM   601  C CB  . THR A 1 76  ? 31.637 -16.589 6.202   1.00 18.11 ? 329 THR A CB  1 
ATOM   602  O OG1 . THR A 1 76  ? 32.799 -15.773 6.304   1.00 20.65 ? 329 THR A OG1 1 
ATOM   603  C CG2 . THR A 1 76  ? 31.155 -16.870 7.601   1.00 18.68 ? 329 THR A CG2 1 
ATOM   604  N N   . TRP A 1 77  ? 30.886 -19.890 6.114   1.00 14.81 ? 330 TRP A N   1 
ATOM   605  C CA  . TRP A 1 77  ? 29.903 -20.951 6.061   1.00 14.74 ? 330 TRP A CA  1 
ATOM   606  C C   . TRP A 1 77  ? 29.264 -21.137 7.434   1.00 14.10 ? 330 TRP A C   1 
ATOM   607  O O   . TRP A 1 77  ? 29.949 -21.230 8.442   1.00 14.88 ? 330 TRP A O   1 
ATOM   608  C CB  . TRP A 1 77  ? 30.572 -22.244 5.629   1.00 15.39 ? 330 TRP A CB  1 
ATOM   609  C CG  . TRP A 1 77  ? 31.194 -22.208 4.274   1.00 15.54 ? 330 TRP A CG  1 
ATOM   610  C CD1 . TRP A 1 77  ? 32.348 -21.578 3.894   1.00 15.79 ? 330 TRP A CD1 1 
ATOM   611  C CD2 . TRP A 1 77  ? 30.693 -22.884 3.119   1.00 15.96 ? 330 TRP A CD2 1 
ATOM   612  N NE1 . TRP A 1 77  ? 32.582 -21.801 2.567   1.00 16.49 ? 330 TRP A NE1 1 
ATOM   613  C CE2 . TRP A 1 77  ? 31.605 -22.626 2.071   1.00 16.84 ? 330 TRP A CE2 1 
ATOM   614  C CE3 . TRP A 1 77  ? 29.596 -23.718 2.876   1.00 16.33 ? 330 TRP A CE3 1 
ATOM   615  C CZ2 . TRP A 1 77  ? 31.418 -23.136 0.790   1.00 17.93 ? 330 TRP A CZ2 1 
ATOM   616  C CZ3 . TRP A 1 77  ? 29.433 -24.247 1.617   1.00 16.98 ? 330 TRP A CZ3 1 
ATOM   617  C CH2 . TRP A 1 77  ? 30.339 -23.960 0.591   1.00 18.11 ? 330 TRP A CH2 1 
ATOM   618  N N   . LEU A 1 78  ? 27.938 -21.250 7.437   1.00 13.51 ? 331 LEU A N   1 
ATOM   619  C CA  . LEU A 1 78  ? 27.187 -21.666 8.615   1.00 13.01 ? 331 LEU A CA  1 
ATOM   620  C C   . LEU A 1 78  ? 27.144 -23.193 8.655   1.00 13.45 ? 331 LEU A C   1 
ATOM   621  O O   . LEU A 1 78  ? 26.642 -23.810 7.714   1.00 15.64 ? 331 LEU A O   1 
ATOM   622  C CB  . LEU A 1 78  ? 25.771 -21.104 8.490   1.00 14.84 ? 331 LEU A CB  1 
ATOM   623  C CG  . LEU A 1 78  ? 24.873 -21.331 9.706   1.00 17.60 ? 331 LEU A CG  1 
ATOM   624  C CD1 . LEU A 1 78  ? 25.350 -20.508 10.890  1.00 21.64 ? 331 LEU A CD1 1 
ATOM   625  C CD2 . LEU A 1 78  ? 23.443 -20.954 9.381   1.00 21.31 ? 331 LEU A CD2 1 
ATOM   626  N N   . THR A 1 79  ? 27.719 -23.780 9.687   1.00 11.88 ? 332 THR A N   1 
ATOM   627  C CA  . THR A 1 79  ? 27.724 -25.227 9.814   1.00 12.17 ? 332 THR A CA  1 
ATOM   628  C C   . THR A 1 79  ? 26.572 -25.642 10.711  1.00 11.64 ? 332 THR A C   1 
ATOM   629  O O   . THR A 1 79  ? 26.169 -24.931 11.631  1.00 11.97 ? 332 THR A O   1 
ATOM   630  C CB  . THR A 1 79  ? 29.061 -25.704 10.386  1.00 13.04 ? 332 THR A CB  1 
ATOM   631  O OG1 . THR A 1 79  ? 29.193 -25.204 11.714  1.00 13.81 ? 332 THR A OG1 1 
ATOM   632  C CG2 . THR A 1 79  ? 30.221 -25.237 9.532   1.00 14.30 ? 332 THR A CG2 1 
ATOM   633  N N   . TYR A 1 80  ? 26.082 -26.858 10.480  1.00 11.42 ? 333 TYR A N   1 
ATOM   634  C CA  . TYR A 1 80  ? 25.020 -27.404 11.309  1.00 11.38 ? 333 TYR A CA  1 
ATOM   635  C C   . TYR A 1 80  ? 25.197 -28.901 11.445  1.00 11.86 ? 333 TYR A C   1 
ATOM   636  O O   . TYR A 1 80  ? 25.605 -29.575 10.497  1.00 12.12 ? 333 TYR A O   1 
ATOM   637  C CB  . TYR A 1 80  ? 23.656 -27.086 10.715  1.00 11.51 ? 333 TYR A CB  1 
ATOM   638  C CG  . TYR A 1 80  ? 23.396 -27.620 9.329   1.00 11.52 ? 333 TYR A CG  1 
ATOM   639  C CD1 . TYR A 1 80  ? 23.736 -26.906 8.199   1.00 12.06 ? 333 TYR A CD1 1 
ATOM   640  C CD2 . TYR A 1 80  ? 22.810 -28.860 9.156   1.00 12.55 ? 333 TYR A CD2 1 
ATOM   641  C CE1 . TYR A 1 80  ? 23.454 -27.378 6.930   1.00 12.33 ? 333 TYR A CE1 1 
ATOM   642  C CE2 . TYR A 1 80  ? 22.523 -29.357 7.896   1.00 12.88 ? 333 TYR A CE2 1 
ATOM   643  C CZ  . TYR A 1 80  ? 22.860 -28.616 6.780   1.00 12.44 ? 333 TYR A CZ  1 
ATOM   644  O OH  . TYR A 1 80  ? 22.617 -29.075 5.502   1.00 13.76 ? 333 TYR A OH  1 
ATOM   645  N N   . THR A 1 81  ? 24.852 -29.427 12.621  1.00 11.88 ? 334 THR A N   1 
ATOM   646  C CA  . THR A 1 81  ? 24.846 -30.860 12.828  1.00 12.07 ? 334 THR A CA  1 
ATOM   647  C C   . THR A 1 81  ? 23.836 -31.176 13.909  1.00 11.98 ? 334 THR A C   1 
ATOM   648  O O   . THR A 1 81  ? 23.567 -30.358 14.789  1.00 12.92 ? 334 THR A O   1 
ATOM   649  C CB  . THR A 1 81  ? 26.240 -31.366 13.212  1.00 13.61 ? 334 THR A CB  1 
ATOM   650  O OG1 . THR A 1 81  ? 26.244 -32.792 13.182  1.00 16.01 ? 334 THR A OG1 1 
ATOM   651  C CG2 . THR A 1 81  ? 26.723 -30.835 14.535  1.00 14.76 ? 334 THR A CG2 1 
ATOM   652  N N   . GLY A 1 82  ? 23.263 -32.373 13.857  1.00 11.05 ? 335 GLY A N   1 
ATOM   653  C CA  . GLY A 1 82  ? 22.338 -32.770 14.898  1.00 11.35 ? 335 GLY A CA  1 
ATOM   654  C C   . GLY A 1 82  ? 21.813 -34.168 14.656  1.00 11.55 ? 335 GLY A C   1 
ATOM   655  O O   . GLY A 1 82  ? 22.305 -34.892 13.787  1.00 12.02 ? 335 GLY A O   1 
ATOM   656  N N   . ALA A 1 83  ? 20.826 -34.527 15.455  1.00 11.43 ? 336 ALA A N   1 
ATOM   657  C CA  . ALA A 1 83  ? 20.219 -35.835 15.362  1.00 12.27 ? 336 ALA A CA  1 
ATOM   658  C C   . ALA A 1 83  ? 18.744 -35.705 15.696  1.00 12.89 ? 336 ALA A C   1 
ATOM   659  O O   . ALA A 1 83  ? 18.387 -34.984 16.620  1.00 14.36 ? 336 ALA A O   1 
ATOM   660  C CB  . ALA A 1 83  ? 20.917 -36.814 16.276  1.00 14.20 ? 336 ALA A CB  1 
ATOM   661  N N   . ILE A 1 84  ? 17.922 -36.412 14.944  1.00 12.92 ? 337 ILE A N   1 
ATOM   662  C CA  . ILE A 1 84  ? 16.480 -36.400 15.089  1.00 13.53 ? 337 ILE A CA  1 
ATOM   663  C C   . ILE A 1 84  ? 16.021 -37.817 15.384  1.00 13.19 ? 337 ILE A C   1 
ATOM   664  O O   . ILE A 1 84  ? 16.265 -38.736 14.608  1.00 13.41 ? 337 ILE A O   1 
ATOM   665  C CB  . ILE A 1 84  ? 15.858 -35.868 13.796  1.00 13.08 ? 337 ILE A CB  1 
ATOM   666  C CG1 . ILE A 1 84  ? 16.223 -34.396 13.593  1.00 14.15 ? 337 ILE A CG1 1 
ATOM   667  C CG2 . ILE A 1 84  ? 14.354 -36.101 13.763  1.00 13.78 ? 337 ILE A CG2 1 
ATOM   668  C CD1 . ILE A 1 84  ? 16.054 -33.920 12.169  1.00 15.35 ? 337 ILE A CD1 1 
ATOM   669  N N   A LYS A 1 85  ? 15.321 -37.977 16.507  0.50 13.97 ? 338 LYS A N   1 
ATOM   670  N N   B LYS A 1 85  ? 15.324 -37.979 16.507  0.50 14.00 ? 338 LYS A N   1 
ATOM   671  C CA  A LYS A 1 85  ? 14.904 -39.298 16.930  0.50 14.79 ? 338 LYS A CA  1 
ATOM   672  C CA  B LYS A 1 85  ? 14.902 -39.298 16.938  0.50 14.86 ? 338 LYS A CA  1 
ATOM   673  C C   A LYS A 1 85  ? 13.652 -39.722 16.166  0.50 14.65 ? 338 LYS A C   1 
ATOM   674  C C   B LYS A 1 85  ? 13.653 -39.724 16.170  0.50 14.68 ? 338 LYS A C   1 
ATOM   675  O O   A LYS A 1 85  ? 12.675 -38.980 16.080  0.50 15.24 ? 338 LYS A O   1 
ATOM   676  O O   B LYS A 1 85  ? 12.676 -38.981 16.087  0.50 15.26 ? 338 LYS A O   1 
ATOM   677  C CB  A LYS A 1 85  ? 14.653 -39.353 18.441  0.50 16.54 ? 338 LYS A CB  1 
ATOM   678  C CB  B LYS A 1 85  ? 14.645 -39.302 18.449  0.50 16.67 ? 338 LYS A CB  1 
ATOM   679  C CG  A LYS A 1 85  ? 14.710 -40.769 19.004  0.50 18.16 ? 338 LYS A CG  1 
ATOM   680  C CG  B LYS A 1 85  ? 14.441 -40.675 19.074  0.50 18.42 ? 338 LYS A CG  1 
ATOM   681  C CD  A LYS A 1 85  ? 14.412 -40.887 20.480  0.50 20.25 ? 338 LYS A CD  1 
ATOM   682  C CD  B LYS A 1 85  ? 14.268 -40.660 20.578  0.50 20.79 ? 338 LYS A CD  1 
ATOM   683  C CE  A LYS A 1 85  ? 12.982 -40.528 20.813  0.50 21.36 ? 338 LYS A CE  1 
ATOM   684  C CE  B LYS A 1 85  ? 13.214 -41.634 21.062  0.50 22.82 ? 338 LYS A CE  1 
ATOM   685  N NZ  A LYS A 1 85  ? 12.893 -39.268 21.582  0.50 23.99 ? 338 LYS A NZ  1 
ATOM   686  N NZ  B LYS A 1 85  ? 13.676 -43.037 21.087  0.50 24.38 ? 338 LYS A NZ  1 
ATOM   687  N N   . LEU A 1 86  ? 13.693 -40.942 15.629  1.00 14.50 ? 339 LEU A N   1 
ATOM   688  C CA  . LEU A 1 86  ? 12.505 -41.559 15.060  1.00 15.14 ? 339 LEU A CA  1 
ATOM   689  C C   . LEU A 1 86  ? 11.601 -42.006 16.205  1.00 15.12 ? 339 LEU A C   1 
ATOM   690  O O   . LEU A 1 86  ? 12.064 -42.343 17.286  1.00 17.12 ? 339 LEU A O   1 
ATOM   691  C CB  . LEU A 1 86  ? 12.871 -42.741 14.162  1.00 16.69 ? 339 LEU A CB  1 
ATOM   692  C CG  . LEU A 1 86  ? 13.174 -42.388 12.710  1.00 18.17 ? 339 LEU A CG  1 
ATOM   693  C CD1 . LEU A 1 86  ? 14.461 -41.590 12.593  1.00 18.48 ? 339 LEU A CD1 1 
ATOM   694  C CD2 . LEU A 1 86  ? 13.234 -43.635 11.852  1.00 18.53 ? 339 LEU A CD2 1 
ATOM   695  N N   . ASP A 1 87  ? 10.300 -42.003 15.940  1.00 15.96 ? 340 ASP A N   1 
ATOM   696  C CA  . ASP A 1 87  ? 9.349  -42.478 16.930  1.00 18.79 ? 340 ASP A CA  1 
ATOM   697  C C   . ASP A 1 87  ? 9.115  -43.965 16.686  1.00 20.64 ? 340 ASP A C   1 
ATOM   698  O O   . ASP A 1 87  ? 8.395  -44.327 15.768  1.00 20.65 ? 340 ASP A O   1 
ATOM   699  C CB  . ASP A 1 87  ? 8.058  -41.671 16.813  1.00 20.59 ? 340 ASP A CB  1 
ATOM   700  C CG  . ASP A 1 87  ? 7.005  -42.047 17.833  1.00 25.04 ? 340 ASP A CG  1 
ATOM   701  O OD1 . ASP A 1 87  ? 5.941  -41.387 17.820  1.00 30.35 ? 340 ASP A OD1 1 
ATOM   702  O OD2 . ASP A 1 87  ? 7.268  -42.971 18.622  1.00 26.62 ? 340 ASP A OD2 1 
ATOM   703  N N   . ASP A 1 88  ? 9.731  -44.823 17.496  1.00 24.73 ? 341 ASP A N   1 
ATOM   704  C CA  . ASP A 1 88  ? 9.637  -46.268 17.303  1.00 30.61 ? 341 ASP A CA  1 
ATOM   705  C C   . ASP A 1 88  ? 8.229  -46.786 17.626  1.00 31.58 ? 341 ASP A C   1 
ATOM   706  O O   . ASP A 1 88  ? 7.912  -47.929 17.290  1.00 35.22 ? 341 ASP A O   1 
ATOM   707  C CB  . ASP A 1 88  ? 10.688 -47.017 18.123  1.00 35.96 ? 341 ASP A CB  1 
ATOM   708  C CG  . ASP A 1 88  ? 10.817 -46.461 19.529  1.00 39.18 ? 341 ASP A CG  1 
ATOM   709  O OD1 . ASP A 1 88  ? 10.159 -47.004 20.443  1.00 46.16 ? 341 ASP A OD1 1 
ATOM   710  O OD2 . ASP A 1 88  ? 11.568 -45.476 19.697  1.00 44.73 ? 341 ASP A OD2 1 
ATOM   711  N N   . LYS A 1 89  ? 7.392  -45.946 18.247  1.00 31.56 ? 342 LYS A N   1 
ATOM   712  C CA  . LYS A 1 89  ? 6.003  -46.287 18.549  1.00 33.37 ? 342 LYS A CA  1 
ATOM   713  C C   . LYS A 1 89  ? 5.075  -45.957 17.374  1.00 30.84 ? 342 LYS A C   1 
ATOM   714  O O   . LYS A 1 89  ? 3.911  -46.350 17.351  1.00 32.00 ? 342 LYS A O   1 
ATOM   715  C CB  . LYS A 1 89  ? 5.497  -45.515 19.772  1.00 35.20 ? 342 LYS A CB  1 
ATOM   716  C CG  . LYS A 1 89  ? 6.404  -45.533 20.999  1.00 39.96 ? 342 LYS A CG  1 
ATOM   717  C CD  . LYS A 1 89  ? 5.977  -44.581 22.094  1.00 43.10 ? 342 LYS A CD  1 
ATOM   718  C CE  . LYS A 1 89  ? 5.067  -45.216 23.123  1.00 45.78 ? 342 LYS A CE  1 
ATOM   719  N NZ  . LYS A 1 89  ? 5.746  -46.323 23.842  1.00 48.56 ? 342 LYS A NZ  1 
ATOM   720  N N   . ASP A 1 90  ? 5.579  -45.189 16.406  1.00 26.17 ? 343 ASP A N   1 
ATOM   721  C CA  . ASP A 1 90  ? 4.879  -44.893 15.167  1.00 25.37 ? 343 ASP A CA  1 
ATOM   722  C C   . ASP A 1 90  ? 4.655  -46.204 14.420  1.00 24.73 ? 343 ASP A C   1 
ATOM   723  O O   . ASP A 1 90  ? 5.603  -46.960 14.189  1.00 23.63 ? 343 ASP A O   1 
ATOM   724  C CB  . ASP A 1 90  ? 5.694  -43.891 14.336  1.00 26.08 ? 343 ASP A CB  1 
ATOM   725  C CG  . ASP A 1 90  ? 4.999  -43.349 13.098  1.00 26.34 ? 343 ASP A CG  1 
ATOM   726  O OD1 . ASP A 1 90  ? 5.353  -42.219 12.681  1.00 26.47 ? 343 ASP A OD1 1 
ATOM   727  O OD2 . ASP A 1 90  ? 4.140  -44.060 12.532  1.00 28.76 ? 343 ASP A OD2 1 
ATOM   728  N N   . PRO A 1 91  ? 3.399  -46.538 14.030  1.00 26.99 ? 344 PRO A N   1 
ATOM   729  C CA  . PRO A 1 91  ? 3.151  -47.773 13.295  1.00 27.65 ? 344 PRO A CA  1 
ATOM   730  C C   . PRO A 1 91  ? 3.974  -47.866 12.013  1.00 25.72 ? 344 PRO A C   1 
ATOM   731  O O   . PRO A 1 91  ? 4.236  -48.961 11.522  1.00 27.26 ? 344 PRO A O   1 
ATOM   732  C CB  . PRO A 1 91  ? 1.645  -47.753 12.969  1.00 27.26 ? 344 PRO A CB  1 
ATOM   733  C CG  . PRO A 1 91  ? 1.149  -46.369 13.347  1.00 28.62 ? 344 PRO A CG  1 
ATOM   734  C CD  . PRO A 1 91  ? 2.162  -45.793 14.313  1.00 28.41 ? 344 PRO A CD  1 
ATOM   735  N N   . ASN A 1 92  ? 4.374  -46.700 11.479  1.00 24.91 ? 345 ASN A N   1 
ATOM   736  C CA  . ASN A 1 92  ? 5.102  -46.653 10.221  1.00 24.79 ? 345 ASN A CA  1 
ATOM   737  C C   . ASN A 1 92  ? 6.612  -46.723 10.447  1.00 21.45 ? 345 ASN A C   1 
ATOM   738  O O   . ASN A 1 92  ? 7.352  -46.585 9.478   1.00 20.71 ? 345 ASN A O   1 
ATOM   739  C CB  . ASN A 1 92  ? 4.771  -45.384 9.434   1.00 28.43 ? 345 ASN A CB  1 
ATOM   740  C CG  . ASN A 1 92  ? 3.307  -45.273 9.081   1.00 31.99 ? 345 ASN A CG  1 
ATOM   741  O OD1 . ASN A 1 92  ? 2.715  -46.222 8.574   1.00 34.27 ? 345 ASN A OD1 1 
ATOM   742  N ND2 . ASN A 1 92  ? 2.715  -44.136 9.394   1.00 33.58 ? 345 ASN A ND2 1 
ATOM   743  N N   . PHE A 1 93  ? 7.074  -46.954 11.680  1.00 20.42 ? 346 PHE A N   1 
ATOM   744  C CA  . PHE A 1 93  ? 8.503  -46.922 11.983  1.00 17.76 ? 346 PHE A CA  1 
ATOM   745  C C   . PHE A 1 93  ? 9.306  -47.844 11.059  1.00 18.34 ? 346 PHE A C   1 
ATOM   746  O O   . PHE A 1 93  ? 10.320 -47.456 10.492  1.00 17.64 ? 346 PHE A O   1 
ATOM   747  C CB  . PHE A 1 93  ? 8.766  -47.303 13.437  1.00 18.32 ? 346 PHE A CB  1 
ATOM   748  C CG  . PHE A 1 93  ? 10.228 -47.419 13.779  1.00 18.33 ? 346 PHE A CG  1 
ATOM   749  C CD1 . PHE A 1 93  ? 10.870 -48.649 13.827  1.00 17.77 ? 346 PHE A CD1 1 
ATOM   750  C CD2 . PHE A 1 93  ? 10.977 -46.282 14.037  1.00 20.88 ? 346 PHE A CD2 1 
ATOM   751  C CE1 . PHE A 1 93  ? 12.211 -48.738 14.132  1.00 17.51 ? 346 PHE A CE1 1 
ATOM   752  C CE2 . PHE A 1 93  ? 12.322 -46.388 14.355  1.00 20.95 ? 346 PHE A CE2 1 
ATOM   753  C CZ  . PHE A 1 93  ? 12.936 -47.613 14.400  1.00 19.18 ? 346 PHE A CZ  1 
ATOM   754  N N   . LYS A 1 94  ? 8.885  -49.103 10.914  1.00 18.94 ? 347 LYS A N   1 
ATOM   755  C CA  . LYS A 1 94  ? 9.673  -50.045 10.137  1.00 19.04 ? 347 LYS A CA  1 
ATOM   756  C C   . LYS A 1 94  ? 9.758  -49.609 8.677   1.00 18.49 ? 347 LYS A C   1 
ATOM   757  O O   . LYS A 1 94  ? 10.811 -49.753 8.059   1.00 18.56 ? 347 LYS A O   1 
ATOM   758  C CB  . LYS A 1 94  ? 9.138  -51.463 10.359  1.00 20.67 ? 347 LYS A CB  1 
ATOM   759  C CG  . LYS A 1 94  ? 9.502  -51.977 11.751  1.00 22.54 ? 347 LYS A CG  1 
ATOM   760  C CD  . LYS A 1 94  ? 9.212  -53.425 12.015  1.00 26.66 ? 347 LYS A CD  1 
ATOM   761  C CE  . LYS A 1 94  ? 7.748  -53.679 12.264  1.00 29.72 ? 347 LYS A CE  1 
ATOM   762  N NZ  . LYS A 1 94  ? 7.543  -55.102 12.614  1.00 31.39 ? 347 LYS A NZ  1 
ATOM   763  N N   . ASP A 1 95  ? 8.680  -49.039 8.146   1.00 18.39 ? 348 ASP A N   1 
ATOM   764  C CA  . ASP A 1 95  ? 8.652  -48.526 6.783   1.00 20.40 ? 348 ASP A CA  1 
ATOM   765  C C   . ASP A 1 95  ? 9.582  -47.316 6.646   1.00 19.32 ? 348 ASP A C   1 
ATOM   766  O O   . ASP A 1 95  ? 10.224 -47.124 5.604   1.00 19.34 ? 348 ASP A O   1 
ATOM   767  C CB  . ASP A 1 95  ? 7.234  -48.137 6.346   1.00 22.34 ? 348 ASP A CB  1 
ATOM   768  C CG  . ASP A 1 95  ? 6.291  -49.301 6.081   1.00 26.47 ? 348 ASP A CG  1 
ATOM   769  O OD1 . ASP A 1 95  ? 5.074  -49.044 5.943   1.00 29.51 ? 348 ASP A OD1 1 
ATOM   770  O OD2 . ASP A 1 95  ? 6.783  -50.447 5.967   1.00 29.48 ? 348 ASP A OD2 1 
ATOM   771  N N   . GLN A 1 96  ? 9.640  -46.486 7.693   1.00 17.89 ? 349 GLN A N   1 
ATOM   772  C CA  . GLN A 1 96  ? 10.515 -45.320 7.668   1.00 17.03 ? 349 GLN A CA  1 
ATOM   773  C C   . GLN A 1 96  ? 11.976 -45.756 7.628   1.00 17.31 ? 349 GLN A C   1 
ATOM   774  O O   . GLN A 1 96  ? 12.777 -45.181 6.908   1.00 17.15 ? 349 GLN A O   1 
ATOM   775  C CB  . GLN A 1 96  ? 10.260 -44.456 8.896   1.00 17.33 ? 349 GLN A CB  1 
ATOM   776  C CG  . GLN A 1 96  ? 8.899  -43.802 8.877   1.00 17.83 ? 349 GLN A CG  1 
ATOM   777  C CD  . GLN A 1 96  ? 8.448  -43.356 10.244  1.00 18.98 ? 349 GLN A CD  1 
ATOM   778  O OE1 . GLN A 1 96  ? 9.168  -43.445 11.239  1.00 20.15 ? 349 GLN A OE1 1 
ATOM   779  N NE2 . GLN A 1 96  ? 7.248  -42.810 10.285  1.00 19.36 ? 349 GLN A NE2 1 
ATOM   780  N N   . VAL A 1 97  ? 12.334 -46.775 8.395   1.00 16.59 ? 350 VAL A N   1 
ATOM   781  C CA  . VAL A 1 97  ? 13.687 -47.291 8.399   1.00 17.03 ? 350 VAL A CA  1 
ATOM   782  C C   . VAL A 1 97  ? 14.042 -47.778 6.998   1.00 18.27 ? 350 VAL A C   1 
ATOM   783  O O   . VAL A 1 97  ? 15.115 -47.466 6.507   1.00 18.15 ? 350 VAL A O   1 
ATOM   784  C CB  . VAL A 1 97  ? 13.861 -48.388 9.469   1.00 17.76 ? 350 VAL A CB  1 
ATOM   785  C CG1 . VAL A 1 97  ? 15.160 -49.166 9.306   1.00 18.52 ? 350 VAL A CG1 1 
ATOM   786  C CG2 . VAL A 1 97  ? 13.762 -47.790 10.863  1.00 18.67 ? 350 VAL A CG2 1 
ATOM   787  N N   . ILE A 1 98  ? 13.135 -48.524 6.368   1.00 18.74 ? 351 ILE A N   1 
ATOM   788  C CA  . ILE A 1 98  ? 13.390 -49.047 5.033   1.00 20.54 ? 351 ILE A CA  1 
ATOM   789  C C   . ILE A 1 98  ? 13.593 -47.890 4.047   1.00 19.52 ? 351 ILE A C   1 
ATOM   790  O O   . ILE A 1 98  ? 14.514 -47.923 3.222   1.00 18.97 ? 351 ILE A O   1 
ATOM   791  C CB  . ILE A 1 98  ? 12.263 -50.001 4.590   1.00 22.69 ? 351 ILE A CB  1 
ATOM   792  C CG1 . ILE A 1 98  ? 12.295 -51.293 5.411   1.00 26.35 ? 351 ILE A CG1 1 
ATOM   793  C CG2 . ILE A 1 98  ? 12.328 -50.259 3.085   1.00 23.55 ? 351 ILE A CG2 1 
ATOM   794  C CD1 . ILE A 1 98  ? 11.093 -52.185 5.233   1.00 28.79 ? 351 ILE A CD1 1 
ATOM   795  N N   . LEU A 1 99  ? 12.714 -46.891 4.112   1.00 18.12 ? 352 LEU A N   1 
ATOM   796  C CA  . LEU A 1 99  ? 12.784 -45.785 3.171   1.00 18.52 ? 352 LEU A CA  1 
ATOM   797  C C   . LEU A 1 99  ? 14.096 -45.019 3.338   1.00 18.62 ? 352 LEU A C   1 
ATOM   798  O O   . LEU A 1 99  ? 14.769 -44.703 2.369   1.00 18.73 ? 352 LEU A O   1 
ATOM   799  C CB  . LEU A 1 99  ? 11.565 -44.886 3.382   1.00 19.49 ? 352 LEU A CB  1 
ATOM   800  C CG  . LEU A 1 99  ? 11.509 -43.614 2.541   1.00 21.16 ? 352 LEU A CG  1 
ATOM   801  C CD1 . LEU A 1 99  ? 11.503 -43.931 1.055   1.00 22.53 ? 352 LEU A CD1 1 
ATOM   802  C CD2 . LEU A 1 99  ? 10.265 -42.815 2.897   1.00 22.05 ? 352 LEU A CD2 1 
ATOM   803  N N   . LEU A 1 100 ? 14.492 -44.738 4.575   1.00 16.97 ? 353 LEU A N   1 
ATOM   804  C CA  . LEU A 1 100 ? 15.711 -43.981 4.800   1.00 16.44 ? 353 LEU A CA  1 
ATOM   805  C C   . LEU A 1 100 ? 16.916 -44.801 4.346   1.00 16.61 ? 353 LEU A C   1 
ATOM   806  O O   . LEU A 1 100 ? 17.794 -44.263 3.681   1.00 17.24 ? 353 LEU A O   1 
ATOM   807  C CB  . LEU A 1 100 ? 15.787 -43.582 6.275   1.00 15.78 ? 353 LEU A CB  1 
ATOM   808  C CG  . LEU A 1 100 ? 14.749 -42.549 6.701   1.00 16.63 ? 353 LEU A CG  1 
ATOM   809  C CD1 . LEU A 1 100 ? 14.672 -42.468 8.216   1.00 18.04 ? 353 LEU A CD1 1 
ATOM   810  C CD2 . LEU A 1 100 ? 15.056 -41.187 6.113   1.00 17.67 ? 353 LEU A CD2 1 
ATOM   811  N N   . ASN A 1 101 ? 16.929 -46.107 4.630   1.00 17.66 ? 354 ASN A N   1 
ATOM   812  C CA  . ASN A 1 101 ? 18.019 -46.978 4.217   1.00 19.11 ? 354 ASN A CA  1 
ATOM   813  C C   . ASN A 1 101 ? 18.135 -47.048 2.692   1.00 18.65 ? 354 ASN A C   1 
ATOM   814  O O   . ASN A 1 101 ? 19.244 -47.249 2.185   1.00 20.47 ? 354 ASN A O   1 
ATOM   815  C CB  . ASN A 1 101 ? 17.856 -48.399 4.770   1.00 21.43 ? 354 ASN A CB  1 
ATOM   816  C CG  . ASN A 1 101 ? 18.227 -48.517 6.228   1.00 22.96 ? 354 ASN A CG  1 
ATOM   817  O OD1 . ASN A 1 101 ? 18.868 -47.643 6.799   1.00 25.92 ? 354 ASN A OD1 1 
ATOM   818  N ND2 . ASN A 1 101 ? 17.821 -49.611 6.846   1.00 23.07 ? 354 ASN A ND2 1 
ATOM   819  N N   . LYS A 1 102 ? 17.014 -46.889 1.982   1.00 17.55 ? 355 LYS A N   1 
ATOM   820  C CA  . LYS A 1 102 ? 17.033 -46.935 0.531   1.00 20.02 ? 355 LYS A CA  1 
ATOM   821  C C   . LYS A 1 102 ? 17.787 -45.742 -0.061  1.00 18.75 ? 355 LYS A C   1 
ATOM   822  O O   . LYS A 1 102 ? 18.266 -45.797 -1.184  1.00 19.30 ? 355 LYS A O   1 
ATOM   823  C CB  . LYS A 1 102 ? 15.593 -46.954 0.015   1.00 24.28 ? 355 LYS A CB  1 
ATOM   824  C CG  . LYS A 1 102 ? 15.492 -47.182 -1.482  1.00 29.96 ? 355 LYS A CG  1 
ATOM   825  C CD  . LYS A 1 102 ? 14.217 -47.868 -1.916  1.00 35.00 ? 355 LYS A CD  1 
ATOM   826  C CE  . LYS A 1 102 ? 13.043 -46.928 -2.042  1.00 38.47 ? 355 LYS A CE  1 
ATOM   827  N NZ  . LYS A 1 102 ? 11.950 -47.588 -2.794  1.00 40.14 ? 355 LYS A NZ  1 
ATOM   828  N N   . HIS A 1 103 ? 17.800 -44.606 0.643   1.00 15.98 ? 356 HIS A N   1 
ATOM   829  C CA  . HIS A 1 103 ? 18.294 -43.350 0.090   1.00 15.64 ? 356 HIS A CA  1 
ATOM   830  C C   . HIS A 1 103 ? 19.652 -42.941 0.650   1.00 14.84 ? 356 HIS A C   1 
ATOM   831  O O   . HIS A 1 103 ? 20.414 -42.236 -0.025  1.00 15.76 ? 356 HIS A O   1 
ATOM   832  C CB  . HIS A 1 103 ? 17.265 -42.247 0.348   1.00 15.44 ? 356 HIS A CB  1 
ATOM   833  C CG  . HIS A 1 103 ? 16.056 -42.450 -0.484  1.00 15.21 ? 356 HIS A CG  1 
ATOM   834  N ND1 . HIS A 1 103 ? 16.047 -42.336 -1.863  1.00 15.80 ? 356 HIS A ND1 1 
ATOM   835  C CD2 . HIS A 1 103 ? 14.851 -42.883 -0.127  1.00 16.73 ? 356 HIS A CD2 1 
ATOM   836  C CE1 . HIS A 1 103 ? 14.823 -42.592 -2.283  1.00 17.22 ? 356 HIS A CE1 1 
ATOM   837  N NE2 . HIS A 1 103 ? 14.092 -42.975 -1.257  1.00 17.60 ? 356 HIS A NE2 1 
ATOM   838  N N   . ILE A 1 104 ? 19.977 -43.342 1.876   1.00 14.11 ? 357 ILE A N   1 
ATOM   839  C CA  . ILE A 1 104 ? 21.239 -42.935 2.466   1.00 14.57 ? 357 ILE A CA  1 
ATOM   840  C C   . ILE A 1 104 ? 22.385 -43.615 1.728   1.00 15.80 ? 357 ILE A C   1 
ATOM   841  O O   . ILE A 1 104 ? 22.464 -44.847 1.729   1.00 16.40 ? 357 ILE A O   1 
ATOM   842  C CB  . ILE A 1 104 ? 21.287 -43.252 3.968   1.00 14.25 ? 357 ILE A CB  1 
ATOM   843  C CG1 . ILE A 1 104 ? 20.291 -42.377 4.726   1.00 14.04 ? 357 ILE A CG1 1 
ATOM   844  C CG2 . ILE A 1 104 ? 22.698 -43.080 4.507   1.00 15.43 ? 357 ILE A CG2 1 
ATOM   845  C CD1 . ILE A 1 104 ? 19.999 -42.846 6.126   1.00 15.57 ? 357 ILE A CD1 1 
ATOM   846  N N   . ASP A 1 105 ? 23.280 -42.824 1.118   1.00 15.60 ? 358 ASP A N   1 
ATOM   847  C CA  . ASP A 1 105 ? 24.451 -43.344 0.422   1.00 16.81 ? 358 ASP A CA  1 
ATOM   848  C C   . ASP A 1 105 ? 24.073 -44.237 -0.755  1.00 16.94 ? 358 ASP A C   1 
ATOM   849  O O   . ASP A 1 105 ? 24.905 -45.034 -1.196  1.00 18.50 ? 358 ASP A O   1 
ATOM   850  C CB  . ASP A 1 105 ? 25.379 -44.087 1.389   1.00 17.79 ? 358 ASP A CB  1 
ATOM   851  C CG  . ASP A 1 105 ? 26.200 -43.181 2.276   1.00 19.42 ? 358 ASP A CG  1 
ATOM   852  O OD1 . ASP A 1 105 ? 26.373 -41.984 1.919   1.00 18.69 ? 358 ASP A OD1 1 
ATOM   853  O OD2 . ASP A 1 105 ? 26.704 -43.664 3.313   1.00 24.49 ? 358 ASP A OD2 1 
ATOM   854  N N   . ALA A 1 106 ? 22.871 -44.089 -1.302  1.00 15.97 ? 359 ALA A N   1 
ATOM   855  C CA  . ALA A 1 106 ? 22.444 -44.895 -2.436  1.00 16.79 ? 359 ALA A CA  1 
ATOM   856  C C   . ALA A 1 106 ? 23.390 -44.699 -3.623  1.00 19.48 ? 359 ALA A C   1 
ATOM   857  O O   . ALA A 1 106 ? 23.604 -45.631 -4.405  1.00 20.85 ? 359 ALA A O   1 
ATOM   858  C CB  . ALA A 1 106 ? 21.024 -44.579 -2.816  1.00 16.91 ? 359 ALA A CB  1 
ATOM   859  N N   . TYR A 1 107 ? 23.956 -43.492 -3.755  1.00 17.73 ? 360 TYR A N   1 
ATOM   860  C CA  . TYR A 1 107 ? 24.786 -43.143 -4.901  1.00 18.85 ? 360 TYR A CA  1 
ATOM   861  C C   . TYR A 1 107 ? 25.998 -44.064 -5.022  1.00 21.23 ? 360 TYR A C   1 
ATOM   862  O O   . TYR A 1 107 ? 26.583 -44.162 -6.098  1.00 22.68 ? 360 TYR A O   1 
ATOM   863  C CB  . TYR A 1 107 ? 25.256 -41.691 -4.805  1.00 18.88 ? 360 TYR A CB  1 
ATOM   864  C CG  . TYR A 1 107 ? 26.374 -41.492 -3.825  1.00 18.76 ? 360 TYR A CG  1 
ATOM   865  C CD1 . TYR A 1 107 ? 27.694 -41.636 -4.228  1.00 20.03 ? 360 TYR A CD1 1 
ATOM   866  C CD2 . TYR A 1 107 ? 26.127 -41.283 -2.471  1.00 17.61 ? 360 TYR A CD2 1 
ATOM   867  C CE1 . TYR A 1 107 ? 28.740 -41.494 -3.339  1.00 20.57 ? 360 TYR A CE1 1 
ATOM   868  C CE2 . TYR A 1 107 ? 27.166 -41.112 -1.576  1.00 18.68 ? 360 TYR A CE2 1 
ATOM   869  C CZ  . TYR A 1 107 ? 28.479 -41.239 -2.004  1.00 19.55 ? 360 TYR A CZ  1 
ATOM   870  O OH  . TYR A 1 107 ? 29.493 -41.147 -1.097  1.00 22.71 ? 360 TYR A OH  1 
ATOM   871  N N   . LYS A 1 108 ? 26.412 -44.718 -3.940  1.00 22.17 ? 361 LYS A N   1 
ATOM   872  C CA  . LYS A 1 108 ? 27.566 -45.604 -3.991  1.00 25.89 ? 361 LYS A CA  1 
ATOM   873  C C   . LYS A 1 108 ? 27.335 -46.768 -4.954  1.00 29.28 ? 361 LYS A C   1 
ATOM   874  O O   . LYS A 1 108 ? 28.301 -47.348 -5.446  1.00 32.28 ? 361 LYS A O   1 
ATOM   875  C CB  . LYS A 1 108 ? 27.902 -46.095 -2.584  1.00 26.85 ? 361 LYS A CB  1 
ATOM   876  C CG  . LYS A 1 108 ? 28.413 -44.999 -1.660  1.00 28.24 ? 361 LYS A CG  1 
ATOM   877  C CD  . LYS A 1 108 ? 28.815 -45.511 -0.293  1.00 29.32 ? 361 LYS A CD  1 
ATOM   878  C CE  . LYS A 1 108 ? 29.387 -44.418 0.583   1.00 31.42 ? 361 LYS A CE  1 
ATOM   879  N NZ  . LYS A 1 108 ? 30.022 -44.939 1.815   1.00 33.77 ? 361 LYS A NZ  1 
ATOM   880  N N   . THR A 1 109 ? 26.071 -47.111 -5.224  1.00 29.50 ? 362 THR A N   1 
ATOM   881  C CA  . THR A 1 109 ? 25.745 -48.276 -6.039  1.00 33.60 ? 362 THR A CA  1 
ATOM   882  C C   . THR A 1 109 ? 25.403 -47.886 -7.479  1.00 35.57 ? 362 THR A C   1 
ATOM   883  O O   . THR A 1 109 ? 25.100 -48.761 -8.287  1.00 38.76 ? 362 THR A O   1 
ATOM   884  C CB  . THR A 1 109 ? 24.570 -49.059 -5.427  1.00 36.61 ? 362 THR A CB  1 
ATOM   885  O OG1 . THR A 1 109 ? 23.364 -48.306 -5.564  1.00 37.91 ? 362 THR A OG1 1 
ATOM   886  C CG2 . THR A 1 109 ? 24.762 -49.366 -3.958  1.00 38.11 ? 362 THR A CG2 1 
ATOM   887  N N   . PHE A 1 110 ? 25.417 -46.594 -7.822  1.00 34.25 ? 363 PHE A N   1 
ATOM   888  C CA  . PHE A 1 110 ? 24.874 -46.183 -9.108  1.00 35.88 ? 363 PHE A CA  1 
ATOM   889  C C   . PHE A 1 110 ? 25.784 -46.679 -10.224 1.00 41.59 ? 363 PHE A C   1 
ATOM   890  O O   . PHE A 1 110 ? 26.998 -46.757 -10.045 1.00 41.99 ? 363 PHE A O   1 
ATOM   891  C CB  . PHE A 1 110 ? 24.764 -44.663 -9.239  1.00 33.56 ? 363 PHE A CB  1 
ATOM   892  C CG  . PHE A 1 110 ? 23.728 -43.987 -8.378  1.00 29.91 ? 363 PHE A CG  1 
ATOM   893  C CD1 . PHE A 1 110 ? 22.805 -44.714 -7.644  1.00 28.55 ? 363 PHE A CD1 1 
ATOM   894  C CD2 . PHE A 1 110 ? 23.689 -42.603 -8.311  1.00 28.91 ? 363 PHE A CD2 1 
ATOM   895  C CE1 . PHE A 1 110 ? 21.881 -44.072 -6.837  1.00 27.09 ? 363 PHE A CE1 1 
ATOM   896  C CE2 . PHE A 1 110 ? 22.747 -41.957 -7.526  1.00 27.20 ? 363 PHE A CE2 1 
ATOM   897  C CZ  . PHE A 1 110 ? 21.855 -42.694 -6.782  1.00 26.03 ? 363 PHE A CZ  1 
ATOM   898  N N   . PRO A 1 111 ? 25.227 -47.008 -11.410 1.00 47.34 ? 364 PRO A N   1 
ATOM   899  C CA  . PRO A 1 111 ? 26.051 -47.246 -12.592 1.00 51.75 ? 364 PRO A CA  1 
ATOM   900  C C   . PRO A 1 111 ? 27.001 -46.079 -12.904 1.00 56.58 ? 364 PRO A C   1 
ATOM   901  O O   . PRO A 1 111 ? 27.194 -45.220 -12.053 1.00 58.11 ? 364 PRO A O   1 
ATOM   902  C CB  . PRO A 1 111 ? 25.018 -47.402 -13.720 1.00 51.27 ? 364 PRO A CB  1 
ATOM   903  C CG  . PRO A 1 111 ? 23.768 -47.884 -13.020 1.00 50.36 ? 364 PRO A CG  1 
ATOM   904  C CD  . PRO A 1 111 ? 23.793 -47.199 -11.671 1.00 47.98 ? 364 PRO A CD  1 
ATOM   905  O OXT . PRO A 1 111 ? 27.508 -46.097 -14.006 1.00 60.35 ? 364 PRO A OXT 1 
ATOM   906  N N   . SER B 1 2   ? 5.352  -32.060 23.814  1.00 47.44 ? 255 SER B N   1 
ATOM   907  C CA  . SER B 1 2   ? 4.874  -33.421 23.454  1.00 46.41 ? 255 SER B CA  1 
ATOM   908  C C   . SER B 1 2   ? 3.961  -33.352 22.229  1.00 44.65 ? 255 SER B C   1 
ATOM   909  O O   . SER B 1 2   ? 3.657  -32.269 21.736  1.00 45.31 ? 255 SER B O   1 
ATOM   910  C CB  . SER B 1 2   ? 4.195  -34.077 24.629  1.00 45.51 ? 255 SER B CB  1 
ATOM   911  O OG  . SER B 1 2   ? 5.082  -34.174 25.733  1.00 47.02 ? 255 SER B OG  1 
ATOM   912  N N   . LYS B 1 3   ? 3.571  -34.539 21.745  1.00 42.28 ? 256 LYS B N   1 
ATOM   913  C CA  . LYS B 1 3   ? 2.682  -34.766 20.607  1.00 39.35 ? 256 LYS B CA  1 
ATOM   914  C C   . LYS B 1 3   ? 3.326  -34.383 19.270  1.00 31.17 ? 256 LYS B C   1 
ATOM   915  O O   . LYS B 1 3   ? 3.339  -35.212 18.373  1.00 31.77 ? 256 LYS B O   1 
ATOM   916  C CB  . LYS B 1 3   ? 1.305  -34.107 20.734  1.00 39.94 ? 256 LYS B CB  1 
ATOM   917  C CG  . LYS B 1 3   ? 0.465  -34.230 19.468  1.00 41.20 ? 256 LYS B CG  1 
ATOM   918  C CD  . LYS B 1 3   ? -1.005 -33.997 19.654  1.00 47.14 ? 256 LYS B CD  1 
ATOM   919  C CE  . LYS B 1 3   ? -1.704 -33.619 18.363  1.00 49.28 ? 256 LYS B CE  1 
ATOM   920  N NZ  . LYS B 1 3   ? -3.000 -32.950 18.627  1.00 50.92 ? 256 LYS B NZ  1 
ATOM   921  N N   . LYS B 1 4   ? 3.760  -33.132 19.068  1.00 29.42 ? 257 LYS B N   1 
ATOM   922  C CA  . LYS B 1 4   ? 4.418  -32.806 17.808  1.00 27.00 ? 257 LYS B CA  1 
ATOM   923  C C   . LYS B 1 4   ? 5.846  -33.345 17.862  1.00 20.33 ? 257 LYS B C   1 
ATOM   924  O O   . LYS B 1 4   ? 6.551  -33.087 18.828  1.00 19.25 ? 257 LYS B O   1 
ATOM   925  C CB  . LYS B 1 4   ? 4.400  -31.296 17.544  1.00 32.61 ? 257 LYS B CB  1 
ATOM   926  C CG  . LYS B 1 4   ? 4.113  -30.918 16.096  1.00 37.01 ? 257 LYS B CG  1 
ATOM   927  C CD  . LYS B 1 4   ? 3.910  -29.436 15.888  1.00 40.85 ? 257 LYS B CD  1 
ATOM   928  C CE  . LYS B 1 4   ? 3.118  -29.117 14.637  1.00 45.28 ? 257 LYS B CE  1 
ATOM   929  N NZ  . LYS B 1 4   ? 2.810  -27.672 14.547  1.00 47.74 ? 257 LYS B NZ  1 
ATOM   930  N N   . PRO B 1 5   ? 6.325  -34.076 16.828  1.00 19.44 ? 258 PRO B N   1 
ATOM   931  C CA  . PRO B 1 5   ? 7.722  -34.486 16.772  1.00 18.54 ? 258 PRO B CA  1 
ATOM   932  C C   . PRO B 1 5   ? 8.616  -33.255 16.887  1.00 15.50 ? 258 PRO B C   1 
ATOM   933  O O   . PRO B 1 5   ? 8.293  -32.196 16.351  1.00 16.24 ? 258 PRO B O   1 
ATOM   934  C CB  . PRO B 1 5   ? 7.861  -35.116 15.382  1.00 19.58 ? 258 PRO B CB  1 
ATOM   935  C CG  . PRO B 1 5   ? 6.448  -35.562 15.047  1.00 21.42 ? 258 PRO B CG  1 
ATOM   936  C CD  . PRO B 1 5   ? 5.562  -34.493 15.647  1.00 21.12 ? 258 PRO B CD  1 
ATOM   937  N N   A ARG B 1 6   ? 9.726  -33.403 17.614  0.50 15.01 ? 259 ARG B N   1 
ATOM   938  N N   B ARG B 1 6   ? 9.728  -33.402 17.607  0.50 15.02 ? 259 ARG B N   1 
ATOM   939  C CA  A ARG B 1 6   ? 10.597 -32.295 17.967  0.50 15.13 ? 259 ARG B CA  1 
ATOM   940  C CA  B ARG B 1 6   ? 10.559 -32.266 17.954  0.50 15.14 ? 259 ARG B CA  1 
ATOM   941  C C   A ARG B 1 6   ? 10.937 -31.463 16.729  0.50 13.96 ? 259 ARG B C   1 
ATOM   942  C C   B ARG B 1 6   ? 10.932 -31.452 16.719  0.50 13.95 ? 259 ARG B C   1 
ATOM   943  O O   A ARG B 1 6   ? 10.881 -30.235 16.768  0.50 13.91 ? 259 ARG B O   1 
ATOM   944  O O   B ARG B 1 6   ? 10.887 -30.221 16.753  0.50 13.81 ? 259 ARG B O   1 
ATOM   945  C CB  A ARG B 1 6   ? 11.862 -32.870 18.616  0.50 16.61 ? 259 ARG B CB  1 
ATOM   946  C CB  B ARG B 1 6   ? 11.822 -32.705 18.684  0.50 16.48 ? 259 ARG B CB  1 
ATOM   947  C CG  A ARG B 1 6   ? 12.768 -31.849 19.282  0.50 17.17 ? 259 ARG B CG  1 
ATOM   948  C CG  B ARG B 1 6   ? 12.556 -31.531 19.296  0.50 17.27 ? 259 ARG B CG  1 
ATOM   949  C CD  A ARG B 1 6   ? 13.969 -32.537 19.918  0.50 17.92 ? 259 ARG B CD  1 
ATOM   950  C CD  B ARG B 1 6   ? 13.696 -31.924 20.216  0.50 18.24 ? 259 ARG B CD  1 
ATOM   951  N NE  A ARG B 1 6   ? 14.838 -31.608 20.619  0.50 18.10 ? 259 ARG B NE  1 
ATOM   952  N NE  B ARG B 1 6   ? 13.237 -32.753 21.319  0.50 19.41 ? 259 ARG B NE  1 
ATOM   953  C CZ  A ARG B 1 6   ? 16.147 -31.487 20.431  0.50 17.51 ? 259 ARG B CZ  1 
ATOM   954  C CZ  B ARG B 1 6   ? 13.303 -32.423 22.602  0.50 20.54 ? 259 ARG B CZ  1 
ATOM   955  N NH1 A ARG B 1 6   ? 16.795 -30.498 20.999  0.50 15.40 ? 259 ARG B NH1 1 
ATOM   956  N NH1 B ARG B 1 6   ? 12.879 -33.280 23.511  0.50 20.55 ? 259 ARG B NH1 1 
ATOM   957  N NH2 A ARG B 1 6   ? 16.802 -32.317 19.639  0.50 18.31 ? 259 ARG B NH2 1 
ATOM   958  N NH2 B ARG B 1 6   ? 13.779 -31.246 22.977  0.50 20.11 ? 259 ARG B NH2 1 
ATOM   959  N N   . GLN B 1 7   ? 11.300 -32.136 15.633  1.00 13.21 ? 260 GLN B N   1 
ATOM   960  C CA  . GLN B 1 7   ? 11.775 -31.462 14.437  1.00 13.08 ? 260 GLN B CA  1 
ATOM   961  C C   . GLN B 1 7   ? 10.710 -30.595 13.770  1.00 12.28 ? 260 GLN B C   1 
ATOM   962  O O   . GLN B 1 7   ? 11.042 -29.755 12.949  1.00 12.76 ? 260 GLN B O   1 
ATOM   963  C CB  . GLN B 1 7   ? 12.344 -32.477 13.442  1.00 13.46 ? 260 GLN B CB  1 
ATOM   964  C CG  . GLN B 1 7   ? 11.327 -33.412 12.797  1.00 14.01 ? 260 GLN B CG  1 
ATOM   965  C CD  . GLN B 1 7   ? 11.064 -34.672 13.577  1.00 13.28 ? 260 GLN B CD  1 
ATOM   966  O OE1 . GLN B 1 7   ? 11.378 -34.785 14.764  1.00 13.32 ? 260 GLN B OE1 1 
ATOM   967  N NE2 . GLN B 1 7   ? 10.485 -35.662 12.917  1.00 14.17 ? 260 GLN B NE2 1 
ATOM   968  N N   . LYS B 1 8   ? 9.418  -30.791 14.100  1.00 12.97 ? 261 LYS B N   1 
ATOM   969  C CA  . LYS B 1 8   ? 8.364  -29.999 13.494  1.00 14.29 ? 261 LYS B CA  1 
ATOM   970  C C   . LYS B 1 8   ? 7.840  -28.918 14.429  1.00 14.79 ? 261 LYS B C   1 
ATOM   971  O O   . LYS B 1 8   ? 6.977  -28.144 14.036  1.00 16.49 ? 261 LYS B O   1 
ATOM   972  C CB  . LYS B 1 8   ? 7.199  -30.895 13.085  1.00 15.07 ? 261 LYS B CB  1 
ATOM   973  C CG  . LYS B 1 8   ? 7.526  -31.858 11.954  1.00 15.52 ? 261 LYS B CG  1 
ATOM   974  C CD  . LYS B 1 8   ? 8.103  -31.164 10.733  1.00 16.31 ? 261 LYS B CD  1 
ATOM   975  C CE  . LYS B 1 8   ? 8.227  -32.085 9.545   1.00 17.16 ? 261 LYS B CE  1 
ATOM   976  N NZ  . LYS B 1 8   ? 8.815  -31.389 8.390   1.00 18.44 ? 261 LYS B NZ  1 
ATOM   977  N N   . ARG B 1 9   ? 8.398  -28.821 15.627  1.00 14.22 ? 262 ARG B N   1 
ATOM   978  C CA  . ARG B 1 9   ? 7.941  -27.814 16.575  1.00 14.14 ? 262 ARG B CA  1 
ATOM   979  C C   . ARG B 1 9   ? 8.407  -26.442 16.131  1.00 14.31 ? 262 ARG B C   1 
ATOM   980  O O   . ARG B 1 9   ? 9.411  -26.280 15.449  1.00 14.78 ? 262 ARG B O   1 
ATOM   981  C CB  . ARG B 1 9   ? 8.505  -28.091 17.962  1.00 14.69 ? 262 ARG B CB  1 
ATOM   982  C CG  . ARG B 1 9   ? 7.944  -29.371 18.556  1.00 15.20 ? 262 ARG B CG  1 
ATOM   983  C CD  . ARG B 1 9   ? 8.634  -29.735 19.842  1.00 15.90 ? 262 ARG B CD  1 
ATOM   984  N NE  . ARG B 1 9   ? 8.171  -31.037 20.267  1.00 16.26 ? 262 ARG B NE  1 
ATOM   985  C CZ  . ARG B 1 9   ? 8.649  -31.720 21.291  1.00 18.45 ? 262 ARG B CZ  1 
ATOM   986  N NH1 . ARG B 1 9   ? 8.195  -32.947 21.489  1.00 19.65 ? 262 ARG B NH1 1 
ATOM   987  N NH2 . ARG B 1 9   ? 9.593  -31.206 22.055  1.00 18.08 ? 262 ARG B NH2 1 
ATOM   988  N N   . THR B 1 10  ? 7.641  -25.447 16.560  1.00 14.34 ? 263 THR B N   1 
ATOM   989  C CA  . THR B 1 10  ? 7.923  -24.052 16.304  1.00 15.47 ? 263 THR B CA  1 
ATOM   990  C C   . THR B 1 10  ? 7.946  -23.357 17.657  1.00 14.72 ? 263 THR B C   1 
ATOM   991  O O   . THR B 1 10  ? 6.940  -23.360 18.370  1.00 17.33 ? 263 THR B O   1 
ATOM   992  C CB  . THR B 1 10  ? 6.846  -23.420 15.418  1.00 18.40 ? 263 THR B CB  1 
ATOM   993  O OG1 . THR B 1 10  ? 6.754  -24.164 14.204  1.00 22.48 ? 263 THR B OG1 1 
ATOM   994  C CG2 . THR B 1 10  ? 7.118  -21.969 15.105  1.00 19.74 ? 263 THR B CG2 1 
ATOM   995  N N   . ALA B 1 11  ? 9.088  -22.785 18.028  1.00 13.16 ? 264 ALA B N   1 
ATOM   996  C CA  . ALA B 1 11  ? 9.166  -22.062 19.285  1.00 12.62 ? 264 ALA B CA  1 
ATOM   997  C C   . ALA B 1 11  ? 8.537  -20.690 19.126  1.00 12.50 ? 264 ALA B C   1 
ATOM   998  O O   . ALA B 1 11  ? 8.705  -20.049 18.093  1.00 12.61 ? 264 ALA B O   1 
ATOM   999  C CB  . ALA B 1 11  ? 10.594 -21.918 19.713  1.00 13.25 ? 264 ALA B CB  1 
ATOM   1000 N N   . THR B 1 12  ? 7.808  -20.279 20.166  1.00 13.20 ? 265 THR B N   1 
ATOM   1001 C CA  . THR B 1 12  ? 7.233  -18.950 20.269  1.00 12.94 ? 265 THR B CA  1 
ATOM   1002 C C   . THR B 1 12  ? 7.327  -18.529 21.724  1.00 13.01 ? 265 THR B C   1 
ATOM   1003 O O   . THR B 1 12  ? 7.791  -19.280 22.554  1.00 13.02 ? 265 THR B O   1 
ATOM   1004 C CB  . THR B 1 12  ? 5.765  -18.941 19.840  1.00 14.00 ? 265 THR B CB  1 
ATOM   1005 O OG1 . THR B 1 12  ? 5.053  -19.795 20.736  1.00 15.50 ? 265 THR B OG1 1 
ATOM   1006 C CG2 . THR B 1 12  ? 5.569  -19.363 18.402  1.00 15.66 ? 265 THR B CG2 1 
ATOM   1007 N N   . LYS B 1 13  ? 6.822  -17.336 22.047  1.00 13.31 ? 266 LYS B N   1 
ATOM   1008 C CA  . LYS B 1 13  ? 6.898  -16.875 23.425  1.00 14.09 ? 266 LYS B CA  1 
ATOM   1009 C C   . LYS B 1 13  ? 6.213  -17.862 24.377  1.00 13.62 ? 266 LYS B C   1 
ATOM   1010 O O   . LYS B 1 13  ? 6.749  -18.136 25.446  1.00 15.51 ? 266 LYS B O   1 
ATOM   1011 C CB  . LYS B 1 13  ? 6.300  -15.475 23.560  1.00 16.19 ? 266 LYS B CB  1 
ATOM   1012 C CG  . LYS B 1 13  ? 6.264  -14.980 24.997  1.00 19.30 ? 266 LYS B CG  1 
ATOM   1013 C CD  . LYS B 1 13  ? 5.614  -13.628 25.153  1.00 22.80 ? 266 LYS B CD  1 
ATOM   1014 C CE  . LYS B 1 13  ? 5.421  -13.244 26.604  1.00 25.60 ? 266 LYS B CE  1 
ATOM   1015 N NZ  . LYS B 1 13  ? 6.679  -13.320 27.385  1.00 28.83 ? 266 LYS B NZ  1 
ATOM   1016 N N   . ALA B 1 14  ? 5.091  -18.445 23.959  1.00 13.21 ? 267 ALA B N   1 
ATOM   1017 C CA  . ALA B 1 14  ? 4.315  -19.324 24.829  1.00 13.20 ? 267 ALA B CA  1 
ATOM   1018 C C   . ALA B 1 14  ? 4.914  -20.725 24.928  1.00 12.94 ? 267 ALA B C   1 
ATOM   1019 O O   . ALA B 1 14  ? 4.550  -21.494 25.807  1.00 14.25 ? 267 ALA B O   1 
ATOM   1020 C CB  . ALA B 1 14  ? 2.911  -19.432 24.322  1.00 14.80 ? 267 ALA B CB  1 
ATOM   1021 N N   . TYR B 1 15  ? 5.793  -21.085 23.987  1.00 12.92 ? 268 TYR B N   1 
ATOM   1022 C CA  . TYR B 1 15  ? 6.430  -22.390 23.966  1.00 12.54 ? 268 TYR B CA  1 
ATOM   1023 C C   . TYR B 1 15  ? 7.823  -22.185 23.379  1.00 11.85 ? 268 TYR B C   1 
ATOM   1024 O O   . TYR B 1 15  ? 8.020  -22.267 22.158  1.00 12.71 ? 268 TYR B O   1 
ATOM   1025 C CB  . TYR B 1 15  ? 5.589  -23.324 23.094  1.00 12.53 ? 268 TYR B CB  1 
ATOM   1026 C CG  . TYR B 1 15  ? 6.036  -24.757 23.050  1.00 12.82 ? 268 TYR B CG  1 
ATOM   1027 C CD1 . TYR B 1 15  ? 6.194  -25.506 24.195  1.00 13.80 ? 268 TYR B CD1 1 
ATOM   1028 C CD2 . TYR B 1 15  ? 6.314  -25.363 21.840  1.00 13.72 ? 268 TYR B CD2 1 
ATOM   1029 C CE1 . TYR B 1 15  ? 6.603  -26.828 24.138  1.00 14.48 ? 268 TYR B CE1 1 
ATOM   1030 C CE2 . TYR B 1 15  ? 6.707  -26.682 21.761  1.00 14.86 ? 268 TYR B CE2 1 
ATOM   1031 C CZ  . TYR B 1 15  ? 6.871  -27.408 22.914  1.00 14.38 ? 268 TYR B CZ  1 
ATOM   1032 O OH  . TYR B 1 15  ? 7.275  -28.720 22.819  1.00 15.88 ? 268 TYR B OH  1 
ATOM   1033 N N   . ASN B 1 16  ? 8.762  -21.817 24.233  1.00 12.35 ? 269 ASN B N   1 
ATOM   1034 C CA  . ASN B 1 16  ? 9.975  -21.148 23.786  1.00 12.73 ? 269 ASN B CA  1 
ATOM   1035 C C   . ASN B 1 16  ? 11.055 -22.163 23.434  1.00 12.72 ? 269 ASN B C   1 
ATOM   1036 O O   . ASN B 1 16  ? 10.802 -23.364 23.370  1.00 13.56 ? 269 ASN B O   1 
ATOM   1037 C CB  . ASN B 1 16  ? 10.399 -20.127 24.832  1.00 12.89 ? 269 ASN B CB  1 
ATOM   1038 C CG  . ASN B 1 16  ? 10.901 -20.756 26.114  1.00 13.44 ? 269 ASN B CG  1 
ATOM   1039 O OD1 . ASN B 1 16  ? 11.424 -21.877 26.142  1.00 13.83 ? 269 ASN B OD1 1 
ATOM   1040 N ND2 . ASN B 1 16  ? 10.795 -20.005 27.189  1.00 14.48 ? 269 ASN B ND2 1 
ATOM   1041 N N   . VAL B 1 17  ? 12.254 -21.663 23.116  1.00 11.50 ? 270 VAL B N   1 
ATOM   1042 C CA  . VAL B 1 17  ? 13.295 -22.536 22.591  1.00 12.09 ? 270 VAL B CA  1 
ATOM   1043 C C   . VAL B 1 17  ? 13.663 -23.607 23.611  1.00 12.36 ? 270 VAL B C   1 
ATOM   1044 O O   . VAL B 1 17  ? 13.868 -24.771 23.253  1.00 12.65 ? 270 VAL B O   1 
ATOM   1045 C CB  . VAL B 1 17  ? 14.514 -21.713 22.161  1.00 12.23 ? 270 VAL B CB  1 
ATOM   1046 C CG1 . VAL B 1 17  ? 15.668 -22.612 21.759  1.00 12.55 ? 270 VAL B CG1 1 
ATOM   1047 C CG2 . VAL B 1 17  ? 14.173 -20.797 21.011  1.00 12.30 ? 270 VAL B CG2 1 
ATOM   1048 N N   . THR B 1 18  ? 13.757 -23.230 24.890  1.00 12.40 ? 271 THR B N   1 
ATOM   1049 C CA  . THR B 1 18  ? 14.052 -24.192 25.931  1.00 13.03 ? 271 THR B CA  1 
ATOM   1050 C C   . THR B 1 18  ? 12.947 -25.237 26.031  1.00 12.03 ? 271 THR B C   1 
ATOM   1051 O O   . THR B 1 18  ? 13.223 -26.427 26.142  1.00 13.00 ? 271 THR B O   1 
ATOM   1052 C CB  . THR B 1 18  ? 14.214 -23.503 27.284  1.00 14.02 ? 271 THR B CB  1 
ATOM   1053 O OG1 . THR B 1 18  ? 15.310 -22.610 27.134  1.00 15.49 ? 271 THR B OG1 1 
ATOM   1054 C CG2 . THR B 1 18  ? 14.488 -24.450 28.430  1.00 15.42 ? 271 THR B CG2 1 
ATOM   1055 N N   . GLN B 1 19  ? 11.685 -24.786 25.987  1.00 12.09 ? 272 GLN B N   1 
ATOM   1056 C CA  . GLN B 1 19  ? 10.580 -25.702 26.176  1.00 13.03 ? 272 GLN B CA  1 
ATOM   1057 C C   . GLN B 1 19  ? 10.497 -26.671 25.002  1.00 12.79 ? 272 GLN B C   1 
ATOM   1058 O O   . GLN B 1 19  ? 10.232 -27.853 25.181  1.00 13.90 ? 272 GLN B O   1 
ATOM   1059 C CB  . GLN B 1 19  ? 9.309  -24.885 26.335  1.00 13.29 ? 272 GLN B CB  1 
ATOM   1060 C CG  . GLN B 1 19  ? 9.242  -24.078 27.615  1.00 13.47 ? 272 GLN B CG  1 
ATOM   1061 C CD  . GLN B 1 19  ? 8.034  -23.177 27.577  1.00 13.81 ? 272 GLN B CD  1 
ATOM   1062 O OE1 . GLN B 1 19  ? 8.039  -22.121 26.966  1.00 15.20 ? 272 GLN B OE1 1 
ATOM   1063 N NE2 . GLN B 1 19  ? 6.993  -23.599 28.277  1.00 16.80 ? 272 GLN B NE2 1 
ATOM   1064 N N   . ALA B 1 20  ? 10.723 -26.174 23.781  1.00 12.25 ? 273 ALA B N   1 
ATOM   1065 C CA  . ALA B 1 20  ? 10.560 -26.990 22.589  1.00 12.41 ? 273 ALA B CA  1 
ATOM   1066 C C   . ALA B 1 20  ? 11.771 -27.872 22.316  1.00 12.52 ? 273 ALA B C   1 
ATOM   1067 O O   . ALA B 1 20  ? 11.608 -28.991 21.837  1.00 13.18 ? 273 ALA B O   1 
ATOM   1068 C CB  . ALA B 1 20  ? 10.279 -26.098 21.410  1.00 13.09 ? 273 ALA B CB  1 
ATOM   1069 N N   . PHE B 1 21  ? 12.969 -27.339 22.588  1.00 11.97 ? 274 PHE B N   1 
ATOM   1070 C CA  . PHE B 1 21  ? 14.191 -27.957 22.077  1.00 12.58 ? 274 PHE B CA  1 
ATOM   1071 C C   . PHE B 1 21  ? 15.245 -28.170 23.149  1.00 13.91 ? 274 PHE B C   1 
ATOM   1072 O O   . PHE B 1 21  ? 16.353 -28.599 22.828  1.00 15.50 ? 274 PHE B O   1 
ATOM   1073 C CB  . PHE B 1 21  ? 14.790 -27.081 20.975  1.00 12.34 ? 274 PHE B CB  1 
ATOM   1074 C CG  . PHE B 1 21  ? 13.829 -26.771 19.867  1.00 12.18 ? 274 PHE B CG  1 
ATOM   1075 C CD1 . PHE B 1 21  ? 13.494 -25.470 19.555  1.00 12.05 ? 274 PHE B CD1 1 
ATOM   1076 C CD2 . PHE B 1 21  ? 13.217 -27.792 19.171  1.00 12.54 ? 274 PHE B CD2 1 
ATOM   1077 C CE1 . PHE B 1 21  ? 12.597 -25.193 18.548  1.00 12.38 ? 274 PHE B CE1 1 
ATOM   1078 C CE2 . PHE B 1 21  ? 12.298 -27.517 18.183  1.00 12.56 ? 274 PHE B CE2 1 
ATOM   1079 C CZ  . PHE B 1 21  ? 12.006 -26.222 17.855  1.00 12.78 ? 274 PHE B CZ  1 
ATOM   1080 N N   . GLY B 1 22  ? 14.918 -27.885 24.403  1.00 13.24 ? 275 GLY B N   1 
ATOM   1081 C CA  . GLY B 1 22  ? 15.837 -28.167 25.488  1.00 13.93 ? 275 GLY B CA  1 
ATOM   1082 C C   . GLY B 1 22  ? 16.764 -26.993 25.771  1.00 13.50 ? 275 GLY B C   1 
ATOM   1083 O O   . GLY B 1 22  ? 16.969 -26.113 24.935  1.00 13.39 ? 275 GLY B O   1 
ATOM   1084 N N   A ARG B 1 23  ? 17.341 -26.979 26.978  0.30 14.39 ? 276 ARG B N   1 
ATOM   1085 N N   B ARG B 1 23  ? 17.321 -26.957 26.985  0.70 15.01 ? 276 ARG B N   1 
ATOM   1086 C CA  A ARG B 1 23  ? 18.276 -25.938 27.366  0.30 15.05 ? 276 ARG B CA  1 
ATOM   1087 C CA  B ARG B 1 23  ? 18.264 -25.922 27.355  0.70 16.37 ? 276 ARG B CA  1 
ATOM   1088 C C   A ARG B 1 23  ? 19.470 -25.974 26.413  0.30 14.20 ? 276 ARG B C   1 
ATOM   1089 C C   B ARG B 1 23  ? 19.457 -25.969 26.400  0.70 14.37 ? 276 ARG B C   1 
ATOM   1090 O O   A ARG B 1 23  ? 19.910 -27.046 26.001  0.30 14.89 ? 276 ARG B O   1 
ATOM   1091 O O   B ARG B 1 23  ? 19.913 -27.044 26.021  0.70 15.82 ? 276 ARG B O   1 
ATOM   1092 C CB  A ARG B 1 23  ? 18.729 -26.156 28.813  0.30 16.67 ? 276 ARG B CB  1 
ATOM   1093 C CB  B ARG B 1 23  ? 18.700 -26.136 28.810  0.70 20.29 ? 276 ARG B CB  1 
ATOM   1094 C CG  A ARG B 1 23  ? 18.570 -24.957 29.742  0.30 18.55 ? 276 ARG B CG  1 
ATOM   1095 C CG  B ARG B 1 23  ? 19.043 -24.867 29.569  0.70 25.33 ? 276 ARG B CG  1 
ATOM   1096 C CD  A ARG B 1 23  ? 18.993 -25.309 31.164  0.30 19.30 ? 276 ARG B CD  1 
ATOM   1097 C CD  B ARG B 1 23  ? 18.957 -25.109 31.070  0.70 27.82 ? 276 ARG B CD  1 
ATOM   1098 N NE  A ARG B 1 23  ? 18.900 -24.236 32.153  0.30 20.24 ? 276 ARG B NE  1 
ATOM   1099 N NE  B ARG B 1 23  ? 17.583 -25.236 31.540  0.70 30.35 ? 276 ARG B NE  1 
ATOM   1100 C CZ  A ARG B 1 23  ? 19.710 -23.180 32.224  0.30 20.47 ? 276 ARG B CZ  1 
ATOM   1101 C CZ  B ARG B 1 23  ? 16.746 -24.217 31.733  0.70 32.05 ? 276 ARG B CZ  1 
ATOM   1102 N NH1 A ARG B 1 23  ? 20.563 -22.929 31.251  0.30 19.43 ? 276 ARG B NH1 1 
ATOM   1103 N NH1 B ARG B 1 23  ? 17.115 -22.982 31.435  0.70 33.28 ? 276 ARG B NH1 1 
ATOM   1104 N NH2 A ARG B 1 23  ? 19.654 -22.367 33.263  0.30 20.11 ? 276 ARG B NH2 1 
ATOM   1105 N NH2 B ARG B 1 23  ? 15.533 -24.436 32.215  0.70 32.87 ? 276 ARG B NH2 1 
ATOM   1106 N N   . ARG B 1 24  ? 19.977 -24.790 26.063  1.00 13.28 ? 277 ARG B N   1 
ATOM   1107 C CA  . ARG B 1 24  ? 21.196 -24.668 25.291  1.00 13.64 ? 277 ARG B CA  1 
ATOM   1108 C C   . ARG B 1 24  ? 22.362 -25.217 26.105  1.00 13.48 ? 277 ARG B C   1 
ATOM   1109 O O   . ARG B 1 24  ? 22.400 -25.107 27.334  1.00 14.36 ? 277 ARG B O   1 
ATOM   1110 C CB  . ARG B 1 24  ? 21.470 -23.206 24.925  1.00 13.57 ? 277 ARG B CB  1 
ATOM   1111 C CG  . ARG B 1 24  ? 20.856 -22.777 23.597  1.00 13.21 ? 277 ARG B CG  1 
ATOM   1112 C CD  . ARG B 1 24  ? 19.339 -22.640 23.588  1.00 12.56 ? 277 ARG B CD  1 
ATOM   1113 N NE  . ARG B 1 24  ? 18.669 -23.915 23.441  1.00 12.47 ? 277 ARG B NE  1 
ATOM   1114 C CZ  . ARG B 1 24  ? 18.579 -24.580 22.302  1.00 11.86 ? 277 ARG B CZ  1 
ATOM   1115 N NH1 . ARG B 1 24  ? 17.994 -25.755 22.283  1.00 12.17 ? 277 ARG B NH1 1 
ATOM   1116 N NH2 . ARG B 1 24  ? 19.114 -24.102 21.197  1.00 11.85 ? 277 ARG B NH2 1 
ATOM   1117 N N   . GLY B 1 25  ? 23.343 -25.797 25.416  1.00 13.60 ? 278 GLY B N   1 
ATOM   1118 C CA  . GLY B 1 25  ? 24.544 -26.227 26.105  1.00 15.06 ? 278 GLY B CA  1 
ATOM   1119 C C   . GLY B 1 25  ? 25.574 -26.790 25.144  1.00 15.05 ? 278 GLY B C   1 
ATOM   1120 O O   . GLY B 1 25  ? 25.429 -26.690 23.928  1.00 15.12 ? 278 GLY B O   1 
ATOM   1121 N N   . PRO B 1 26  ? 26.665 -27.348 25.704  1.00 16.81 ? 279 PRO B N   1 
ATOM   1122 C CA  . PRO B 1 26  ? 27.817 -27.771 24.914  1.00 17.12 ? 279 PRO B CA  1 
ATOM   1123 C C   . PRO B 1 26  ? 27.803 -29.195 24.365  1.00 18.68 ? 279 PRO B C   1 
ATOM   1124 O O   . PRO B 1 26  ? 28.678 -29.549 23.584  1.00 18.55 ? 279 PRO B O   1 
ATOM   1125 C CB  . PRO B 1 26  ? 28.942 -27.652 25.952  1.00 18.45 ? 279 PRO B CB  1 
ATOM   1126 C CG  . PRO B 1 26  ? 28.275 -28.083 27.232  1.00 17.66 ? 279 PRO B CG  1 
ATOM   1127 C CD  . PRO B 1 26  ? 26.906 -27.450 27.141  1.00 17.11 ? 279 PRO B CD  1 
ATOM   1128 N N   . GLU B 1 27  ? 26.834 -30.011 24.801  1.00 17.64 ? 280 GLU B N   1 
ATOM   1129 C CA  . GLU B 1 27  ? 26.921 -31.438 24.527  1.00 18.35 ? 280 GLU B CA  1 
ATOM   1130 C C   . GLU B 1 27  ? 26.540 -31.737 23.083  1.00 20.49 ? 280 GLU B C   1 
ATOM   1131 O O   . GLU B 1 27  ? 25.902 -30.948 22.404  1.00 19.82 ? 280 GLU B O   1 
ATOM   1132 C CB  . GLU B 1 27  ? 26.090 -32.252 25.518  1.00 18.86 ? 280 GLU B CB  1 
ATOM   1133 C CG  . GLU B 1 27  ? 26.473 -32.020 26.958  1.00 18.32 ? 280 GLU B CG  1 
ATOM   1134 C CD  . GLU B 1 27  ? 27.924 -32.290 27.351  1.00 19.63 ? 280 GLU B CD  1 
ATOM   1135 O OE1 . GLU B 1 27  ? 28.414 -31.653 28.285  1.00 22.42 ? 280 GLU B OE1 1 
ATOM   1136 O OE2 . GLU B 1 27  ? 28.569 -33.179 26.743  1.00 23.34 ? 280 GLU B OE2 1 
ATOM   1137 N N   . GLN B 1 28  ? 26.962 -32.905 22.615  1.00 22.12 ? 281 GLN B N   1 
ATOM   1138 C CA  . GLN B 1 28  ? 27.076 -33.183 21.192  1.00 27.26 ? 281 GLN B CA  1 
ATOM   1139 C C   . GLN B 1 28  ? 25.773 -33.018 20.415  1.00 30.61 ? 281 GLN B C   1 
ATOM   1140 O O   . GLN B 1 28  ? 25.816 -32.556 19.278  1.00 35.70 ? 281 GLN B O   1 
ATOM   1141 C CB  . GLN B 1 28  ? 27.652 -34.580 20.950  1.00 30.91 ? 281 GLN B CB  1 
ATOM   1142 C CG  . GLN B 1 28  ? 29.161 -34.569 20.732  1.00 35.79 ? 281 GLN B CG  1 
ATOM   1143 C CD  . GLN B 1 28  ? 29.571 -33.667 19.588  1.00 39.96 ? 281 GLN B CD  1 
ATOM   1144 O OE1 . GLN B 1 28  ? 30.094 -32.572 19.792  1.00 41.03 ? 281 GLN B OE1 1 
ATOM   1145 N NE2 . GLN B 1 28  ? 29.322 -34.112 18.366  1.00 45.49 ? 281 GLN B NE2 1 
ATOM   1146 N N   . THR B 1 29  ? 24.640 -33.464 20.948  1.00 31.25 ? 282 THR B N   1 
ATOM   1147 C CA  . THR B 1 29  ? 23.405 -33.356 20.167  1.00 26.47 ? 282 THR B CA  1 
ATOM   1148 C C   . THR B 1 29  ? 22.457 -32.371 20.835  1.00 26.88 ? 282 THR B C   1 
ATOM   1149 O O   . THR B 1 29  ? 21.252 -32.382 20.601  1.00 28.79 ? 282 THR B O   1 
ATOM   1150 C CB  . THR B 1 29  ? 22.751 -34.722 19.911  1.00 26.55 ? 282 THR B CB  1 
ATOM   1151 O OG1 . THR B 1 29  ? 22.576 -35.346 21.183  1.00 26.76 ? 282 THR B OG1 1 
ATOM   1152 C CG2 . THR B 1 29  ? 23.568 -35.579 18.967  1.00 26.38 ? 282 THR B CG2 1 
ATOM   1153 N N   . GLN B 1 30  ? 23.031 -31.512 21.681  1.00 24.08 ? 283 GLN B N   1 
ATOM   1154 C CA  . GLN B 1 30  ? 22.309 -30.476 22.396  1.00 20.92 ? 283 GLN B CA  1 
ATOM   1155 C C   . GLN B 1 30  ? 22.448 -29.169 21.628  1.00 16.53 ? 283 GLN B C   1 
ATOM   1156 O O   . GLN B 1 30  ? 23.520 -28.888 21.133  1.00 16.16 ? 283 GLN B O   1 
ATOM   1157 C CB  . GLN B 1 30  ? 23.023 -30.331 23.728  1.00 22.39 ? 283 GLN B CB  1 
ATOM   1158 C CG  . GLN B 1 30  ? 22.513 -29.225 24.596  1.00 20.39 ? 283 GLN B CG  1 
ATOM   1159 C CD  . GLN B 1 30  ? 23.105 -29.265 25.984  1.00 22.64 ? 283 GLN B CD  1 
ATOM   1160 O OE1 . GLN B 1 30  ? 24.289 -29.568 26.180  1.00 20.43 ? 283 GLN B OE1 1 
ATOM   1161 N NE2 . GLN B 1 30  ? 22.302 -28.856 26.953  1.00 25.04 ? 283 GLN B NE2 1 
ATOM   1162 N N   . GLY B 1 31  ? 21.381 -28.387 21.504  1.00 14.39 ? 284 GLY B N   1 
ATOM   1163 C CA  . GLY B 1 31  ? 21.465 -27.161 20.727  1.00 13.14 ? 284 GLY B CA  1 
ATOM   1164 C C   . GLY B 1 31  ? 22.321 -26.111 21.433  1.00 13.20 ? 284 GLY B C   1 
ATOM   1165 O O   . GLY B 1 31  ? 22.300 -25.997 22.662  1.00 13.70 ? 284 GLY B O   1 
ATOM   1166 N N   . ASN B 1 32  ? 23.038 -25.313 20.644  1.00 12.44 ? 285 ASN B N   1 
ATOM   1167 C CA  . ASN B 1 32  ? 23.924 -24.305 21.197  1.00 12.66 ? 285 ASN B CA  1 
ATOM   1168 C C   . ASN B 1 32  ? 23.523 -22.905 20.753  1.00 11.97 ? 285 ASN B C   1 
ATOM   1169 O O   . ASN B 1 32  ? 24.243 -21.965 21.071  1.00 12.65 ? 285 ASN B O   1 
ATOM   1170 C CB  . ASN B 1 32  ? 25.381 -24.566 20.814  1.00 12.64 ? 285 ASN B CB  1 
ATOM   1171 C CG  . ASN B 1 32  ? 25.635 -24.350 19.349  1.00 12.96 ? 285 ASN B CG  1 
ATOM   1172 O OD1 . ASN B 1 32  ? 24.734 -24.502 18.532  1.00 13.24 ? 285 ASN B OD1 1 
ATOM   1173 N ND2 . ASN B 1 32  ? 26.833 -23.914 19.015  1.00 14.12 ? 285 ASN B ND2 1 
ATOM   1174 N N   . PHE B 1 33  ? 22.412 -22.749 20.041  1.00 11.25 ? 286 PHE B N   1 
ATOM   1175 C CA  . PHE B 1 33  ? 22.105 -21.487 19.386  1.00 11.35 ? 286 PHE B CA  1 
ATOM   1176 C C   . PHE B 1 33  ? 21.002 -20.750 20.136  1.00 12.02 ? 286 PHE B C   1 
ATOM   1177 O O   . PHE B 1 33  ? 19.927 -21.287 20.363  1.00 11.60 ? 286 PHE B O   1 
ATOM   1178 C CB  . PHE B 1 33  ? 21.694 -21.755 17.944  1.00 11.52 ? 286 PHE B CB  1 
ATOM   1179 C CG  . PHE B 1 33  ? 21.545 -20.542 17.070  1.00 11.45 ? 286 PHE B CG  1 
ATOM   1180 C CD1 . PHE B 1 33  ? 20.353 -19.845 16.985  1.00 11.27 ? 286 PHE B CD1 1 
ATOM   1181 C CD2 . PHE B 1 33  ? 22.618 -20.096 16.310  1.00 12.21 ? 286 PHE B CD2 1 
ATOM   1182 C CE1 . PHE B 1 33  ? 20.232 -18.764 16.122  1.00 11.84 ? 286 PHE B CE1 1 
ATOM   1183 C CE2 . PHE B 1 33  ? 22.497 -19.001 15.463  1.00 12.01 ? 286 PHE B CE2 1 
ATOM   1184 C CZ  . PHE B 1 33  ? 21.300 -18.350 15.360  1.00 11.87 ? 286 PHE B CZ  1 
ATOM   1185 N N   . GLY B 1 34  ? 21.310 -19.500 20.465  1.00 11.54 ? 287 GLY B N   1 
ATOM   1186 C CA  . GLY B 1 34  ? 20.329 -18.557 20.962  1.00 11.74 ? 287 GLY B CA  1 
ATOM   1187 C C   . GLY B 1 34  ? 20.814 -17.824 22.198  1.00 12.37 ? 287 GLY B C   1 
ATOM   1188 O O   . GLY B 1 34  ? 21.281 -18.436 23.148  1.00 12.54 ? 287 GLY B O   1 
ATOM   1189 N N   . ASP B 1 35  ? 20.698 -16.492 22.142  1.00 12.51 ? 288 ASP B N   1 
ATOM   1190 C CA  . ASP B 1 35  ? 20.896 -15.670 23.327  1.00 12.96 ? 288 ASP B CA  1 
ATOM   1191 C C   . ASP B 1 35  ? 19.595 -15.661 24.128  1.00 13.07 ? 288 ASP B C   1 
ATOM   1192 O O   . ASP B 1 35  ? 18.615 -16.309 23.771  1.00 12.79 ? 288 ASP B O   1 
ATOM   1193 C CB  . ASP B 1 35  ? 21.409 -14.277 22.949  1.00 13.16 ? 288 ASP B CB  1 
ATOM   1194 C CG  . ASP B 1 35  ? 20.379 -13.366 22.318  1.00 13.28 ? 288 ASP B CG  1 
ATOM   1195 O OD1 . ASP B 1 35  ? 20.780 -12.218 21.960  1.00 15.66 ? 288 ASP B OD1 1 
ATOM   1196 O OD2 . ASP B 1 35  ? 19.223 -13.756 22.179  1.00 13.76 ? 288 ASP B OD2 1 
ATOM   1197 N N   . GLN B 1 36  ? 19.566 -14.932 25.252  1.00 12.79 ? 289 GLN B N   1 
ATOM   1198 C CA  . GLN B 1 36  ? 18.401 -15.008 26.122  1.00 13.72 ? 289 GLN B CA  1 
ATOM   1199 C C   . GLN B 1 36  ? 17.143 -14.508 25.425  1.00 13.83 ? 289 GLN B C   1 
ATOM   1200 O O   . GLN B 1 36  ? 16.064 -15.045 25.642  1.00 14.80 ? 289 GLN B O   1 
ATOM   1201 C CB  . GLN B 1 36  ? 18.652 -14.233 27.409  1.00 15.56 ? 289 GLN B CB  1 
ATOM   1202 C CG  . GLN B 1 36  ? 19.634 -14.957 28.296  1.00 17.92 ? 289 GLN B CG  1 
ATOM   1203 C CD  . GLN B 1 36  ? 20.088 -14.202 29.511  1.00 22.27 ? 289 GLN B CD  1 
ATOM   1204 O OE1 . GLN B 1 36  ? 19.706 -14.535 30.634  1.00 28.72 ? 289 GLN B OE1 1 
ATOM   1205 N NE2 . GLN B 1 36  ? 20.979 -13.253 29.262  1.00 23.90 ? 289 GLN B NE2 1 
ATOM   1206 N N   . GLU B 1 37  ? 17.283 -13.472 24.586  1.00 13.25 ? 290 GLU B N   1 
ATOM   1207 C CA  . GLU B 1 37  ? 16.124 -12.911 23.919  1.00 14.21 ? 290 GLU B CA  1 
ATOM   1208 C C   . GLU B 1 37  ? 15.514 -13.918 22.938  1.00 13.18 ? 290 GLU B C   1 
ATOM   1209 O O   . GLU B 1 37  ? 14.320 -14.169 22.928  1.00 13.62 ? 290 GLU B O   1 
ATOM   1210 C CB  . GLU B 1 37  ? 16.546 -11.618 23.238  1.00 15.97 ? 290 GLU B CB  1 
ATOM   1211 C CG  . GLU B 1 37  ? 15.418 -10.852 22.609  1.00 18.13 ? 290 GLU B CG  1 
ATOM   1212 C CD  . GLU B 1 37  ? 15.840 -9.593  21.868  1.00 19.49 ? 290 GLU B CD  1 
ATOM   1213 O OE1 . GLU B 1 37  ? 17.038 -9.385  21.655  1.00 22.02 ? 290 GLU B OE1 1 
ATOM   1214 O OE2 . GLU B 1 37  ? 14.936 -8.818  21.512  1.00 25.80 ? 290 GLU B OE2 1 
ATOM   1215 N N   . LEU B 1 38  ? 16.367 -14.536 22.110  1.00 12.70 ? 291 LEU B N   1 
ATOM   1216 C CA  . LEU B 1 38  ? 15.857 -15.505 21.158  1.00 12.40 ? 291 LEU B CA  1 
ATOM   1217 C C   . LEU B 1 38  ? 15.308 -16.732 21.881  1.00 12.11 ? 291 LEU B C   1 
ATOM   1218 O O   . LEU B 1 38  ? 14.286 -17.269 21.486  1.00 12.51 ? 291 LEU B O   1 
ATOM   1219 C CB  . LEU B 1 38  ? 16.942 -15.897 20.155  1.00 12.36 ? 291 LEU B CB  1 
ATOM   1220 C CG  . LEU B 1 38  ? 16.557 -17.033 19.209  1.00 12.58 ? 291 LEU B CG  1 
ATOM   1221 C CD1 . LEU B 1 38  ? 15.294 -16.703 18.419  1.00 13.31 ? 291 LEU B CD1 1 
ATOM   1222 C CD2 . LEU B 1 38  ? 17.675 -17.368 18.254  1.00 13.75 ? 291 LEU B CD2 1 
ATOM   1223 N N   . ILE B 1 39  ? 15.981 -17.167 22.939  1.00 12.21 ? 292 ILE B N   1 
ATOM   1224 C CA  . ILE B 1 39  ? 15.497 -18.331 23.669  1.00 12.19 ? 292 ILE B CA  1 
ATOM   1225 C C   . ILE B 1 39  ? 14.077 -18.095 24.162  1.00 12.56 ? 292 ILE B C   1 
ATOM   1226 O O   . ILE B 1 39  ? 13.241 -18.996 24.057  1.00 11.92 ? 292 ILE B O   1 
ATOM   1227 C CB  . ILE B 1 39  ? 16.452 -18.699 24.812  1.00 12.43 ? 292 ILE B CB  1 
ATOM   1228 C CG1 . ILE B 1 39  ? 17.740 -19.303 24.267  1.00 12.96 ? 292 ILE B CG1 1 
ATOM   1229 C CG2 . ILE B 1 39  ? 15.783 -19.647 25.799  1.00 13.01 ? 292 ILE B CG2 1 
ATOM   1230 C CD1 . ILE B 1 39  ? 18.854 -19.368 25.276  1.00 13.90 ? 292 ILE B CD1 1 
ATOM   1231 N N   A ARG B 1 40  ? 13.815 -16.900 24.702  0.50 12.82 ? 293 ARG B N   1 
ATOM   1232 N N   B ARG B 1 40  ? 13.809 -16.898 24.704  0.50 12.50 ? 293 ARG B N   1 
ATOM   1233 C CA  A ARG B 1 40  ? 12.521 -16.606 25.285  0.50 13.45 ? 293 ARG B CA  1 
ATOM   1234 C CA  B ARG B 1 40  ? 12.513 -16.645 25.308  0.50 12.87 ? 293 ARG B CA  1 
ATOM   1235 C C   A ARG B 1 40  ? 11.452 -16.386 24.216  0.50 13.73 ? 293 ARG B C   1 
ATOM   1236 C C   B ARG B 1 40  ? 11.461 -16.308 24.252  0.50 13.40 ? 293 ARG B C   1 
ATOM   1237 O O   A ARG B 1 40  ? 10.277 -16.692 24.425  0.50 15.17 ? 293 ARG B O   1 
ATOM   1238 O O   B ARG B 1 40  ? 10.275 -16.344 24.563  0.50 15.53 ? 293 ARG B O   1 
ATOM   1239 C CB  A ARG B 1 40  ? 12.632 -15.359 26.157  0.50 14.80 ? 293 ARG B CB  1 
ATOM   1240 C CB  B ARG B 1 40  ? 12.608 -15.602 26.433  0.50 13.63 ? 293 ARG B CB  1 
ATOM   1241 C CG  A ARG B 1 40  ? 11.289 -14.893 26.703  0.50 16.17 ? 293 ARG B CG  1 
ATOM   1242 C CG  B ARG B 1 40  ? 13.027 -14.188 26.044  0.50 14.25 ? 293 ARG B CG  1 
ATOM   1243 C CD  A ARG B 1 40  ? 11.458 -13.693 27.608  0.50 16.78 ? 293 ARG B CD  1 
ATOM   1244 C CD  B ARG B 1 40  ? 13.353 -13.329 27.266  0.50 15.11 ? 293 ARG B CD  1 
ATOM   1245 N NE  A ARG B 1 40  ? 11.915 -12.534 26.859  0.50 17.24 ? 293 ARG B NE  1 
ATOM   1246 N NE  B ARG B 1 40  ? 13.938 -12.034 26.941  0.50 15.76 ? 293 ARG B NE  1 
ATOM   1247 C CZ  A ARG B 1 40  ? 13.150 -12.040 26.897  0.50 16.86 ? 293 ARG B CZ  1 
ATOM   1248 C CZ  B ARG B 1 40  ? 13.258 -10.994 26.471  0.50 17.04 ? 293 ARG B CZ  1 
ATOM   1249 N NH1 A ARG B 1 40  ? 14.112 -12.680 27.540  0.50 17.23 ? 293 ARG B NH1 1 
ATOM   1250 N NH1 B ARG B 1 40  ? 13.890 -9.904  26.066  0.50 17.71 ? 293 ARG B NH1 1 
ATOM   1251 N NH2 A ARG B 1 40  ? 13.429 -10.932 26.230  0.50 18.70 ? 293 ARG B NH2 1 
ATOM   1252 N NH2 B ARG B 1 40  ? 11.943 -11.067 26.370  0.50 16.64 ? 293 ARG B NH2 1 
ATOM   1253 N N   . GLN B 1 41  ? 11.850 -15.959 23.016  1.00 13.64 ? 294 GLN B N   1 
ATOM   1254 C CA  . GLN B 1 41  ? 10.872 -15.514 22.030  1.00 14.28 ? 294 GLN B CA  1 
ATOM   1255 C C   . GLN B 1 41  ? 10.675 -16.486 20.865  1.00 13.77 ? 294 GLN B C   1 
ATOM   1256 O O   . GLN B 1 41  ? 9.640  -16.463 20.209  1.00 13.62 ? 294 GLN B O   1 
ATOM   1257 C CB  . GLN B 1 41  ? 11.257 -14.135 21.513  1.00 14.55 ? 294 GLN B CB  1 
ATOM   1258 C CG  . GLN B 1 41  ? 11.182 -13.094 22.620  1.00 16.90 ? 294 GLN B CG  1 
ATOM   1259 C CD  . GLN B 1 41  ? 11.610 -11.731 22.148  1.00 19.36 ? 294 GLN B CD  1 
ATOM   1260 O OE1 . GLN B 1 41  ? 12.256 -11.575 21.119  1.00 20.37 ? 294 GLN B OE1 1 
ATOM   1261 N NE2 . GLN B 1 41  ? 11.294 -10.716 22.935  1.00 21.11 ? 294 GLN B NE2 1 
ATOM   1262 N N   . GLY B 1 42  ? 11.695 -17.294 20.552  1.00 13.07 ? 295 GLY B N   1 
ATOM   1263 C CA  . GLY B 1 42  ? 11.589 -18.187 19.405  1.00 13.83 ? 295 GLY B CA  1 
ATOM   1264 C C   . GLY B 1 42  ? 11.299 -17.403 18.131  1.00 12.87 ? 295 GLY B C   1 
ATOM   1265 O O   . GLY B 1 42  ? 11.911 -16.371 17.887  1.00 13.65 ? 295 GLY B O   1 
ATOM   1266 N N   . THR B 1 43  ? 10.309 -17.854 17.362  1.00 13.08 ? 296 THR B N   1 
ATOM   1267 C CA  . THR B 1 43  ? 9.993  -17.227 16.085  1.00 13.56 ? 296 THR B CA  1 
ATOM   1268 C C   . THR B 1 43  ? 9.301  -15.879 16.278  1.00 14.41 ? 296 THR B C   1 
ATOM   1269 O O   . THR B 1 43  ? 9.088  -15.194 15.287  1.00 16.49 ? 296 THR B O   1 
ATOM   1270 C CB  . THR B 1 43  ? 9.141  -18.152 15.213  1.00 14.90 ? 296 THR B CB  1 
ATOM   1271 O OG1 . THR B 1 43  ? 7.918  -18.399 15.900  1.00 15.94 ? 296 THR B OG1 1 
ATOM   1272 C CG2 . THR B 1 43  ? 9.820  -19.466 14.914  1.00 14.82 ? 296 THR B CG2 1 
ATOM   1273 N N   . ASP B 1 44  ? 8.957  -15.503 17.515  1.00 13.76 ? 297 ASP B N   1 
ATOM   1274 C CA  . ASP B 1 44  ? 8.457  -14.166 17.808  1.00 14.43 ? 297 ASP B CA  1 
ATOM   1275 C C   . ASP B 1 44  ? 9.594  -13.158 17.934  1.00 15.93 ? 297 ASP B C   1 
ATOM   1276 O O   . ASP B 1 44  ? 9.351  -11.952 18.016  1.00 16.77 ? 297 ASP B O   1 
ATOM   1277 C CB  . ASP B 1 44  ? 7.605  -14.150 19.077  1.00 15.55 ? 297 ASP B CB  1 
ATOM   1278 C CG  . ASP B 1 44  ? 6.309  -14.930 18.954  1.00 17.01 ? 297 ASP B CG  1 
ATOM   1279 O OD1 . ASP B 1 44  ? 5.921  -15.580 19.950  1.00 18.79 ? 297 ASP B OD1 1 
ATOM   1280 O OD2 . ASP B 1 44  ? 5.686  -14.865 17.867  1.00 19.48 ? 297 ASP B OD2 1 
ATOM   1281 N N   . TYR B 1 45  ? 10.840 -13.613 17.960  1.00 14.60 ? 298 TYR B N   1 
ATOM   1282 C CA  . TYR B 1 45  ? 12.007 -12.747 17.974  1.00 14.56 ? 298 TYR B CA  1 
ATOM   1283 C C   . TYR B 1 45  ? 11.932 -11.790 16.795  1.00 14.37 ? 298 TYR B C   1 
ATOM   1284 O O   . TYR B 1 45  ? 11.662 -12.206 15.671  1.00 15.04 ? 298 TYR B O   1 
ATOM   1285 C CB  . TYR B 1 45  ? 13.247 -13.628 17.864  1.00 14.28 ? 298 TYR B CB  1 
ATOM   1286 C CG  . TYR B 1 45  ? 14.591 -12.963 17.925  1.00 14.45 ? 298 TYR B CG  1 
ATOM   1287 C CD1 . TYR B 1 45  ? 15.466 -13.081 16.866  1.00 14.47 ? 298 TYR B CD1 1 
ATOM   1288 C CD2 . TYR B 1 45  ? 15.062 -12.356 19.073  1.00 16.17 ? 298 TYR B CD2 1 
ATOM   1289 C CE1 . TYR B 1 45  ? 16.752 -12.572 16.919  1.00 15.04 ? 298 TYR B CE1 1 
ATOM   1290 C CE2 . TYR B 1 45  ? 16.356 -11.864 19.154  1.00 17.85 ? 298 TYR B CE2 1 
ATOM   1291 C CZ  . TYR B 1 45  ? 17.199 -11.948 18.063  1.00 16.44 ? 298 TYR B CZ  1 
ATOM   1292 O OH  . TYR B 1 45  ? 18.479 -11.464 18.119  1.00 17.53 ? 298 TYR B OH  1 
ATOM   1293 N N   . LYS B 1 46  ? 12.167 -10.501 17.031  1.00 15.70 ? 299 LYS B N   1 
ATOM   1294 C CA  . LYS B 1 46  ? 11.848 -9.534  15.988  1.00 17.96 ? 299 LYS B CA  1 
ATOM   1295 C C   . LYS B 1 46  ? 12.842 -9.628  14.830  1.00 16.76 ? 299 LYS B C   1 
ATOM   1296 O O   . LYS B 1 46  ? 12.505 -9.170  13.748  1.00 19.21 ? 299 LYS B O   1 
ATOM   1297 C CB  . LYS B 1 46  ? 11.686 -8.117  16.550  1.00 21.27 ? 299 LYS B CB  1 
ATOM   1298 C CG  . LYS B 1 46  ? 10.502 -7.924  17.494  1.00 23.66 ? 299 LYS B CG  1 
ATOM   1299 C CD  . LYS B 1 46  ? 9.149  -7.957  16.815  1.00 28.44 ? 299 LYS B CD  1 
ATOM   1300 C CE  . LYS B 1 46  ? 7.995  -7.781  17.778  1.00 31.22 ? 299 LYS B CE  1 
ATOM   1301 N NZ  . LYS B 1 46  ? 6.695  -8.039  17.114  1.00 34.49 ? 299 LYS B NZ  1 
ATOM   1302 N N   . HIS B 1 47  ? 14.026 -10.220 15.022  1.00 16.07 ? 300 HIS B N   1 
ATOM   1303 C CA  . HIS B 1 47  ? 14.954 -10.431 13.918  1.00 16.36 ? 300 HIS B CA  1 
ATOM   1304 C C   . HIS B 1 47  ? 14.942 -11.882 13.440  1.00 15.10 ? 300 HIS B C   1 
ATOM   1305 O O   . HIS B 1 47  ? 15.854 -12.309 12.725  1.00 16.39 ? 300 HIS B O   1 
ATOM   1306 C CB  . HIS B 1 47  ? 16.360 -10.002 14.343  1.00 19.60 ? 300 HIS B CB  1 
ATOM   1307 C CG  . HIS B 1 47  ? 16.305 -8.615  14.874  1.00 24.72 ? 300 HIS B CG  1 
ATOM   1308 N ND1 . HIS B 1 47  ? 16.241 -7.610  13.951  1.00 25.86 ? 300 HIS B ND1 1 
ATOM   1309 C CD2 . HIS B 1 47  ? 16.130 -8.051  16.074  1.00 27.70 ? 300 HIS B CD2 1 
ATOM   1310 C CE1 . HIS B 1 47  ? 16.124 -6.440  14.578  1.00 24.17 ? 300 HIS B CE1 1 
ATOM   1311 N NE2 . HIS B 1 47  ? 16.032 -6.695  15.874  1.00 27.41 ? 300 HIS B NE2 1 
ATOM   1312 N N   . TRP B 1 48  ? 13.902 -12.634 13.785  1.00 13.94 ? 301 TRP B N   1 
ATOM   1313 C CA  . TRP B 1 48  ? 13.839 -14.031 13.379  1.00 13.46 ? 301 TRP B CA  1 
ATOM   1314 C C   . TRP B 1 48  ? 13.967 -14.179 11.869  1.00 14.74 ? 301 TRP B C   1 
ATOM   1315 O O   . TRP B 1 48  ? 14.654 -15.090 11.413  1.00 14.00 ? 301 TRP B O   1 
ATOM   1316 C CB  . TRP B 1 48  ? 12.564 -14.698 13.891  1.00 13.64 ? 301 TRP B CB  1 
ATOM   1317 C CG  . TRP B 1 48  ? 12.468 -16.119 13.449  1.00 12.92 ? 301 TRP B CG  1 
ATOM   1318 C CD1 . TRP B 1 48  ? 11.606 -16.618 12.530  1.00 13.24 ? 301 TRP B CD1 1 
ATOM   1319 C CD2 . TRP B 1 48  ? 13.340 -17.191 13.827  1.00 12.30 ? 301 TRP B CD2 1 
ATOM   1320 N NE1 . TRP B 1 48  ? 11.869 -17.953 12.322  1.00 13.23 ? 301 TRP B NE1 1 
ATOM   1321 C CE2 . TRP B 1 48  ? 12.911 -18.330 13.115  1.00 12.87 ? 301 TRP B CE2 1 
ATOM   1322 C CE3 . TRP B 1 48  ? 14.400 -17.308 14.721  1.00 13.27 ? 301 TRP B CE3 1 
ATOM   1323 C CZ2 . TRP B 1 48  ? 13.537 -19.569 13.246  1.00 13.10 ? 301 TRP B CZ2 1 
ATOM   1324 C CZ3 . TRP B 1 48  ? 15.011 -18.532 14.854  1.00 13.65 ? 301 TRP B CZ3 1 
ATOM   1325 C CH2 . TRP B 1 48  ? 14.577 -19.643 14.133  1.00 13.72 ? 301 TRP B CH2 1 
ATOM   1326 N N   . PRO B 1 49  ? 13.337 -13.345 11.013  1.00 14.75 ? 302 PRO B N   1 
ATOM   1327 C CA  . PRO B 1 49  ? 13.459 -13.556 9.564   1.00 15.13 ? 302 PRO B CA  1 
ATOM   1328 C C   . PRO B 1 49  ? 14.900 -13.572 9.077   1.00 15.48 ? 302 PRO B C   1 
ATOM   1329 O O   . PRO B 1 49  ? 15.213 -14.310 8.143   1.00 16.52 ? 302 PRO B O   1 
ATOM   1330 C CB  . PRO B 1 49  ? 12.671 -12.392 8.958   1.00 16.35 ? 302 PRO B CB  1 
ATOM   1331 C CG  . PRO B 1 49  ? 11.668 -12.070 10.032  1.00 17.20 ? 302 PRO B CG  1 
ATOM   1332 C CD  . PRO B 1 49  ? 12.402 -12.253 11.342  1.00 15.88 ? 302 PRO B CD  1 
ATOM   1333 N N   . GLN B 1 50  ? 15.781 -12.792 9.711   1.00 14.58 ? 303 GLN B N   1 
ATOM   1334 C CA  . GLN B 1 50  ? 17.162 -12.717 9.271   1.00 16.34 ? 303 GLN B CA  1 
ATOM   1335 C C   . GLN B 1 50  ? 17.959 -13.948 9.715   1.00 16.74 ? 303 GLN B C   1 
ATOM   1336 O O   . GLN B 1 50  ? 19.039 -14.194 9.176   1.00 17.19 ? 303 GLN B O   1 
ATOM   1337 C CB  . GLN B 1 50  ? 17.800 -11.409 9.730   1.00 17.32 ? 303 GLN B CB  1 
ATOM   1338 C CG  . GLN B 1 50  ? 17.322 -10.203 8.921   1.00 19.55 ? 303 GLN B CG  1 
ATOM   1339 C CD  . GLN B 1 50  ? 15.907 -9.785  9.249   1.00 20.05 ? 303 GLN B CD  1 
ATOM   1340 O OE1 . GLN B 1 50  ? 15.547 -9.637  10.413  1.00 21.04 ? 303 GLN B OE1 1 
ATOM   1341 N NE2 . GLN B 1 50  ? 15.086 -9.578  8.237   1.00 20.34 ? 303 GLN B NE2 1 
ATOM   1342 N N   . ILE B 1 51  ? 17.429 -14.720 10.676  1.00 15.34 ? 304 ILE B N   1 
ATOM   1343 C CA  . ILE B 1 51  ? 17.994 -16.018 11.022  1.00 14.39 ? 304 ILE B CA  1 
ATOM   1344 C C   . ILE B 1 51  ? 17.409 -17.081 10.097  1.00 14.15 ? 304 ILE B C   1 
ATOM   1345 O O   . ILE B 1 51  ? 18.149 -17.896 9.526   1.00 14.39 ? 304 ILE B O   1 
ATOM   1346 C CB  . ILE B 1 51  ? 17.724 -16.346 12.502  1.00 13.88 ? 304 ILE B CB  1 
ATOM   1347 C CG1 . ILE B 1 51  ? 18.447 -15.356 13.407  1.00 15.05 ? 304 ILE B CG1 1 
ATOM   1348 C CG2 . ILE B 1 51  ? 18.113 -17.801 12.814  1.00 14.35 ? 304 ILE B CG2 1 
ATOM   1349 C CD1 . ILE B 1 51  ? 18.061 -15.425 14.863  1.00 15.70 ? 304 ILE B CD1 1 
ATOM   1350 N N   . ALA B 1 52  ? 16.098 -17.057 9.941   1.00 13.52 ? 305 ALA B N   1 
ATOM   1351 C CA  . ALA B 1 52  ? 15.389 -18.105 9.227   1.00 14.88 ? 305 ALA B CA  1 
ATOM   1352 C C   . ALA B 1 52  ? 15.805 -18.148 7.753   1.00 15.18 ? 305 ALA B C   1 
ATOM   1353 O O   . ALA B 1 52  ? 15.637 -19.185 7.118   1.00 15.16 ? 305 ALA B O   1 
ATOM   1354 C CB  . ALA B 1 52  ? 13.907 -17.904 9.368   1.00 15.69 ? 305 ALA B CB  1 
ATOM   1355 N N   . GLN B 1 53  ? 16.351 -17.060 7.202   1.00 14.24 ? 306 GLN B N   1 
ATOM   1356 C CA  . GLN B 1 53  ? 16.792 -17.063 5.813   1.00 15.66 ? 306 GLN B CA  1 
ATOM   1357 C C   . GLN B 1 53  ? 17.886 -18.110 5.601   1.00 15.33 ? 306 GLN B C   1 
ATOM   1358 O O   . GLN B 1 53  ? 18.154 -18.492 4.464   1.00 15.92 ? 306 GLN B O   1 
ATOM   1359 C CB  . GLN B 1 53  ? 17.304 -15.687 5.386   1.00 17.03 ? 306 GLN B CB  1 
ATOM   1360 C CG  . GLN B 1 53  ? 18.664 -15.323 5.955   1.00 18.63 ? 306 GLN B CG  1 
ATOM   1361 C CD  . GLN B 1 53  ? 19.049 -13.911 5.570   1.00 19.80 ? 306 GLN B CD  1 
ATOM   1362 O OE1 . GLN B 1 53  ? 19.048 -13.556 4.389   1.00 22.90 ? 306 GLN B OE1 1 
ATOM   1363 N NE2 . GLN B 1 53  ? 19.374 -13.094 6.559   1.00 20.16 ? 306 GLN B NE2 1 
ATOM   1364 N N   . PHE B 1 54  ? 18.531 -18.572 6.670   1.00 14.24 ? 307 PHE B N   1 
ATOM   1365 C CA  . PHE B 1 54  ? 19.553 -19.599 6.561   1.00 14.82 ? 307 PHE B CA  1 
ATOM   1366 C C   . PHE B 1 54  ? 19.018 -21.007 6.765   1.00 15.19 ? 307 PHE B C   1 
ATOM   1367 O O   . PHE B 1 54  ? 19.735 -21.946 6.454   1.00 16.66 ? 307 PHE B O   1 
ATOM   1368 C CB  . PHE B 1 54  ? 20.710 -19.299 7.513   1.00 15.83 ? 307 PHE B CB  1 
ATOM   1369 C CG  . PHE B 1 54  ? 21.369 -17.992 7.173   1.00 16.54 ? 307 PHE B CG  1 
ATOM   1370 C CD1 . PHE B 1 54  ? 22.031 -17.857 5.963   1.00 18.62 ? 307 PHE B CD1 1 
ATOM   1371 C CD2 . PHE B 1 54  ? 21.225 -16.869 7.979   1.00 16.59 ? 307 PHE B CD2 1 
ATOM   1372 C CE1 . PHE B 1 54  ? 22.630 -16.655 5.618   1.00 20.40 ? 307 PHE B CE1 1 
ATOM   1373 C CE2 . PHE B 1 54  ? 21.821 -15.674 7.631   1.00 17.89 ? 307 PHE B CE2 1 
ATOM   1374 C CZ  . PHE B 1 54  ? 22.491 -15.558 6.436   1.00 19.50 ? 307 PHE B CZ  1 
ATOM   1375 N N   . ALA B 1 55  ? 17.802 -21.161 7.280   1.00 14.20 ? 308 ALA B N   1 
ATOM   1376 C CA  . ALA B 1 55  ? 17.272 -22.486 7.546   1.00 14.30 ? 308 ALA B CA  1 
ATOM   1377 C C   . ALA B 1 55  ? 16.892 -23.146 6.231   1.00 14.91 ? 308 ALA B C   1 
ATOM   1378 O O   . ALA B 1 55  ? 16.359 -22.509 5.330   1.00 16.14 ? 308 ALA B O   1 
ATOM   1379 C CB  . ALA B 1 55  ? 16.079 -22.413 8.443   1.00 13.92 ? 308 ALA B CB  1 
ATOM   1380 N N   . PRO B 1 56  ? 17.166 -24.450 6.068   1.00 14.08 ? 309 PRO B N   1 
ATOM   1381 C CA  . PRO B 1 56  ? 16.867 -25.113 4.799   1.00 13.80 ? 309 PRO B CA  1 
ATOM   1382 C C   . PRO B 1 56  ? 15.418 -25.523 4.626   1.00 13.31 ? 309 PRO B C   1 
ATOM   1383 O O   . PRO B 1 56  ? 14.754 -25.928 5.579   1.00 14.17 ? 309 PRO B O   1 
ATOM   1384 C CB  . PRO B 1 56  ? 17.754 -26.351 4.850   1.00 15.16 ? 309 PRO B CB  1 
ATOM   1385 C CG  . PRO B 1 56  ? 17.870 -26.651 6.311   1.00 14.24 ? 309 PRO B CG  1 
ATOM   1386 C CD  . PRO B 1 56  ? 17.941 -25.291 6.984   1.00 14.07 ? 309 PRO B CD  1 
ATOM   1387 N N   . SER B 1 57  ? 14.921 -25.455 3.394   1.00 13.66 ? 310 SER B N   1 
ATOM   1388 C CA  . SER B 1 57  ? 13.688 -26.125 3.026   1.00 13.38 ? 310 SER B CA  1 
ATOM   1389 C C   . SER B 1 57  ? 13.843 -27.621 3.285   1.00 13.62 ? 310 SER B C   1 
ATOM   1390 O O   . SER B 1 57  ? 14.956 -28.123 3.421   1.00 13.42 ? 310 SER B O   1 
ATOM   1391 C CB  . SER B 1 57  ? 13.386 -25.893 1.571   1.00 14.18 ? 310 SER B CB  1 
ATOM   1392 O OG  . SER B 1 57  ? 14.358 -26.545 0.760   1.00 14.92 ? 310 SER B OG  1 
ATOM   1393 N N   . ALA B 1 58  ? 12.738 -28.363 3.322   1.00 13.39 ? 311 ALA B N   1 
ATOM   1394 C CA  . ALA B 1 58  ? 12.849 -29.799 3.518   1.00 13.53 ? 311 ALA B CA  1 
ATOM   1395 C C   . ALA B 1 58  ? 13.673 -30.427 2.397   1.00 13.33 ? 311 ALA B C   1 
ATOM   1396 O O   . ALA B 1 58  ? 14.472 -31.322 2.628   1.00 13.99 ? 311 ALA B O   1 
ATOM   1397 C CB  . ALA B 1 58  ? 11.482 -30.428 3.609   1.00 14.74 ? 311 ALA B CB  1 
ATOM   1398 N N   . SER B 1 59  ? 13.434 -29.982 1.164   1.00 13.54 ? 312 SER B N   1 
ATOM   1399 C CA  . SER B 1 59  ? 14.165 -30.467 0.008   1.00 13.34 ? 312 SER B CA  1 
ATOM   1400 C C   . SER B 1 59  ? 15.652 -30.190 0.164   1.00 13.62 ? 312 SER B C   1 
ATOM   1401 O O   . SER B 1 59  ? 16.476 -31.065 -0.066  1.00 13.23 ? 312 SER B O   1 
ATOM   1402 C CB  . SER B 1 59  ? 13.586 -29.810 -1.224  1.00 15.13 ? 312 SER B CB  1 
ATOM   1403 O OG  . SER B 1 59  ? 14.195 -30.312 -2.405  1.00 16.19 ? 312 SER B OG  1 
ATOM   1404 N N   . ALA B 1 60  ? 16.002 -28.962 0.560   1.00 12.87 ? 313 ALA B N   1 
ATOM   1405 C CA  . ALA B 1 60  ? 17.406 -28.627 0.744   1.00 13.04 ? 313 ALA B CA  1 
ATOM   1406 C C   . ALA B 1 60  ? 18.015 -29.379 1.921   1.00 13.18 ? 313 ALA B C   1 
ATOM   1407 O O   . ALA B 1 60  ? 19.173 -29.762 1.874   1.00 13.47 ? 313 ALA B O   1 
ATOM   1408 C CB  . ALA B 1 60  ? 17.576 -27.138 0.899   1.00 12.99 ? 313 ALA B CB  1 
ATOM   1409 N N   . PHE B 1 61  ? 17.252 -29.599 2.988   1.00 12.76 ? 314 PHE B N   1 
ATOM   1410 C CA  . PHE B 1 61  ? 17.792 -30.331 4.116   1.00 12.45 ? 314 PHE B CA  1 
ATOM   1411 C C   . PHE B 1 61  ? 18.243 -31.724 3.666   1.00 11.63 ? 314 PHE B C   1 
ATOM   1412 O O   . PHE B 1 61  ? 19.346 -32.161 3.976   1.00 12.98 ? 314 PHE B O   1 
ATOM   1413 C CB  . PHE B 1 61  ? 16.730 -30.422 5.203   1.00 12.78 ? 314 PHE B CB  1 
ATOM   1414 C CG  . PHE B 1 61  ? 17.154 -31.206 6.413   1.00 12.55 ? 314 PHE B CG  1 
ATOM   1415 C CD1 . PHE B 1 61  ? 17.971 -30.636 7.366   1.00 13.55 ? 314 PHE B CD1 1 
ATOM   1416 C CD2 . PHE B 1 61  ? 16.745 -32.519 6.570   1.00 13.29 ? 314 PHE B CD2 1 
ATOM   1417 C CE1 . PHE B 1 61  ? 18.371 -31.369 8.474   1.00 14.25 ? 314 PHE B CE1 1 
ATOM   1418 C CE2 . PHE B 1 61  ? 17.125 -33.241 7.687   1.00 13.42 ? 314 PHE B CE2 1 
ATOM   1419 C CZ  . PHE B 1 61  ? 17.931 -32.657 8.630   1.00 14.02 ? 314 PHE B CZ  1 
ATOM   1420 N N   . PHE B 1 62  ? 17.381 -32.421 2.920   1.00 12.13 ? 315 PHE B N   1 
ATOM   1421 C CA  . PHE B 1 62  ? 17.738 -33.741 2.428   1.00 12.56 ? 315 PHE B CA  1 
ATOM   1422 C C   . PHE B 1 62  ? 18.620 -33.714 1.187   1.00 12.25 ? 315 PHE B C   1 
ATOM   1423 O O   . PHE B 1 62  ? 19.231 -34.732 0.896   1.00 13.62 ? 315 PHE B O   1 
ATOM   1424 C CB  . PHE B 1 62  ? 16.478 -34.567 2.197   1.00 12.43 ? 315 PHE B CB  1 
ATOM   1425 C CG  . PHE B 1 62  ? 15.982 -35.174 3.479   1.00 12.52 ? 315 PHE B CG  1 
ATOM   1426 C CD1 . PHE B 1 62  ? 14.936 -34.617 4.192   1.00 13.23 ? 315 PHE B CD1 1 
ATOM   1427 C CD2 . PHE B 1 62  ? 16.630 -36.277 4.004   1.00 13.80 ? 315 PHE B CD2 1 
ATOM   1428 C CE1 . PHE B 1 62  ? 14.524 -35.182 5.386   1.00 13.54 ? 315 PHE B CE1 1 
ATOM   1429 C CE2 . PHE B 1 62  ? 16.221 -36.835 5.204   1.00 13.71 ? 315 PHE B CE2 1 
ATOM   1430 C CZ  . PHE B 1 62  ? 15.190 -36.263 5.906   1.00 13.68 ? 315 PHE B CZ  1 
ATOM   1431 N N   . GLY B 1 63  ? 18.713 -32.578 0.496   1.00 12.70 ? 316 GLY B N   1 
ATOM   1432 C CA  . GLY B 1 63  ? 19.534 -32.473 -0.700  1.00 12.88 ? 316 GLY B CA  1 
ATOM   1433 C C   . GLY B 1 63  ? 20.969 -32.070 -0.396  1.00 13.72 ? 316 GLY B C   1 
ATOM   1434 O O   . GLY B 1 63  ? 21.883 -32.511 -1.078  1.00 13.44 ? 316 GLY B O   1 
ATOM   1435 N N   . MET B 1 64  ? 21.162 -31.204 0.599   1.00 13.65 ? 317 MET B N   1 
ATOM   1436 C CA  . MET B 1 64  ? 22.463 -30.647 0.897   1.00 14.04 ? 317 MET B CA  1 
ATOM   1437 C C   . MET B 1 64  ? 23.204 -31.466 1.947   1.00 14.43 ? 317 MET B C   1 
ATOM   1438 O O   . MET B 1 64  ? 24.423 -31.457 1.965   1.00 16.84 ? 317 MET B O   1 
ATOM   1439 C CB  . MET B 1 64  ? 22.298 -29.241 1.474   1.00 14.74 ? 317 MET B CB  1 
ATOM   1440 C CG  . MET B 1 64  ? 21.725 -28.252 0.501   1.00 14.52 ? 317 MET B CG  1 
ATOM   1441 S SD  . MET B 1 64  ? 21.684 -26.585 1.182   1.00 16.88 ? 317 MET B SD  1 
ATOM   1442 C CE  . MET B 1 64  ? 21.074 -26.843 2.847   1.00 17.69 ? 317 MET B CE  1 
ATOM   1443 N N   . SER B 1 65  ? 22.476 -32.081 2.885   1.00 13.55 ? 318 SER B N   1 
ATOM   1444 C CA  . SER B 1 65  ? 23.081 -32.586 4.111   1.00 13.41 ? 318 SER B CA  1 
ATOM   1445 C C   . SER B 1 65  ? 23.705 -33.963 3.924   1.00 13.21 ? 318 SER B C   1 
ATOM   1446 O O   . SER B 1 65  ? 23.328 -34.741 3.040   1.00 13.69 ? 318 SER B O   1 
ATOM   1447 C CB  . SER B 1 65  ? 22.079 -32.689 5.218   1.00 13.18 ? 318 SER B CB  1 
ATOM   1448 O OG  . SER B 1 65  ? 21.425 -31.469 5.449   1.00 13.27 ? 318 SER B OG  1 
ATOM   1449 N N   . ARG B 1 66  ? 24.641 -34.276 4.811   1.00 12.84 ? 319 ARG B N   1 
ATOM   1450 C CA  . ARG B 1 66  ? 25.080 -35.648 5.001   1.00 12.87 ? 319 ARG B CA  1 
ATOM   1451 C C   . ARG B 1 66  ? 24.150 -36.298 6.015   1.00 13.12 ? 319 ARG B C   1 
ATOM   1452 O O   . ARG B 1 66  ? 24.120 -35.880 7.177   1.00 13.52 ? 319 ARG B O   1 
ATOM   1453 C CB  . ARG B 1 66  ? 26.547 -35.652 5.425   1.00 15.15 ? 319 ARG B CB  1 
ATOM   1454 C CG  . ARG B 1 66  ? 27.406 -34.786 4.505   1.00 18.88 ? 319 ARG B CG  1 
ATOM   1455 C CD  . ARG B 1 66  ? 28.867 -35.155 4.426   1.00 22.14 ? 319 ARG B CD  1 
ATOM   1456 N NE  . ARG B 1 66  ? 29.050 -36.566 4.129   1.00 22.04 ? 319 ARG B NE  1 
ATOM   1457 C CZ  . ARG B 1 66  ? 28.737 -37.164 2.984   1.00 22.56 ? 319 ARG B CZ  1 
ATOM   1458 N NH1 . ARG B 1 66  ? 28.797 -38.484 2.915   1.00 21.18 ? 319 ARG B NH1 1 
ATOM   1459 N NH2 . ARG B 1 66  ? 28.365 -36.457 1.924   1.00 21.10 ? 319 ARG B NH2 1 
ATOM   1460 N N   . ILE B 1 67  ? 23.371 -37.279 5.555   1.00 12.66 ? 320 ILE B N   1 
ATOM   1461 C CA  . ILE B 1 67  ? 22.348 -37.930 6.358   1.00 13.11 ? 320 ILE B CA  1 
ATOM   1462 C C   . ILE B 1 67  ? 22.842 -39.311 6.772   1.00 13.40 ? 320 ILE B C   1 
ATOM   1463 O O   . ILE B 1 67  ? 23.476 -40.020 5.973   1.00 15.08 ? 320 ILE B O   1 
ATOM   1464 C CB  . ILE B 1 67  ? 21.041 -38.051 5.561   1.00 12.86 ? 320 ILE B CB  1 
ATOM   1465 C CG1 . ILE B 1 67  ? 20.521 -36.701 5.065   1.00 13.33 ? 320 ILE B CG1 1 
ATOM   1466 C CG2 . ILE B 1 67  ? 19.992 -38.793 6.380   1.00 13.52 ? 320 ILE B CG2 1 
ATOM   1467 C CD1 . ILE B 1 67  ? 20.127 -35.735 6.162   1.00 13.56 ? 320 ILE B CD1 1 
ATOM   1468 N N   . GLY B 1 68  ? 22.555 -39.699 8.011   1.00 14.19 ? 321 GLY B N   1 
ATOM   1469 C CA  . GLY B 1 68  ? 22.920 -41.020 8.475   1.00 14.14 ? 321 GLY B CA  1 
ATOM   1470 C C   . GLY B 1 68  ? 21.869 -41.504 9.454   1.00 14.78 ? 321 GLY B C   1 
ATOM   1471 O O   . GLY B 1 68  ? 20.918 -40.793 9.774   1.00 14.04 ? 321 GLY B O   1 
ATOM   1472 N N   A MET B 1 69  ? 22.062 -42.735 9.911   0.60 15.99 ? 322 MET B N   1 
ATOM   1473 N N   B MET B 1 69  ? 22.007 -42.758 9.882   0.40 15.36 ? 322 MET B N   1 
ATOM   1474 C CA  A MET B 1 69  ? 21.157 -43.360 10.855  0.60 17.33 ? 322 MET B CA  1 
ATOM   1475 C CA  B MET B 1 69  ? 21.097 -43.326 10.860  0.40 16.17 ? 322 MET B CA  1 
ATOM   1476 C C   A MET B 1 69  ? 22.006 -44.013 11.928  0.60 17.32 ? 322 MET B C   1 
ATOM   1477 C C   B MET B 1 69  ? 21.922 -44.058 11.909  0.40 16.44 ? 322 MET B C   1 
ATOM   1478 O O   A MET B 1 69  ? 23.005 -44.667 11.610  0.60 20.17 ? 322 MET B O   1 
ATOM   1479 O O   B MET B 1 69  ? 22.787 -44.848 11.550  0.40 18.07 ? 322 MET B O   1 
ATOM   1480 C CB  A MET B 1 69  ? 20.327 -44.425 10.142  0.60 19.58 ? 322 MET B CB  1 
ATOM   1481 C CB  B MET B 1 69  ? 20.118 -44.296 10.192  0.40 17.37 ? 322 MET B CB  1 
ATOM   1482 C CG  A MET B 1 69  ? 19.412 -43.813 9.126   0.60 22.29 ? 322 MET B CG  1 
ATOM   1483 C CG  B MET B 1 69  ? 19.365 -45.124 11.190  0.40 18.50 ? 322 MET B CG  1 
ATOM   1484 S SD  A MET B 1 69  ? 17.886 -43.302 9.857   0.60 28.76 ? 322 MET B SD  1 
ATOM   1485 S SD  B MET B 1 69  ? 18.187 -46.217 10.377  0.40 22.57 ? 322 MET B SD  1 
ATOM   1486 C CE  A MET B 1 69  ? 17.222 -44.959 10.058  0.60 20.46 ? 322 MET B CE  1 
ATOM   1487 C CE  B MET B 1 69  ? 17.206 -44.994 9.520   0.40 19.16 ? 322 MET B CE  1 
ATOM   1488 N N   . GLU B 1 70  ? 21.616 -43.813 13.186  1.00 16.06 ? 323 GLU B N   1 
ATOM   1489 C CA  . GLU B 1 70  ? 22.270 -44.466 14.306  1.00 17.09 ? 323 GLU B CA  1 
ATOM   1490 C C   . GLU B 1 70  ? 21.218 -45.146 15.169  1.00 16.78 ? 323 GLU B C   1 
ATOM   1491 O O   . GLU B 1 70  ? 20.206 -44.559 15.502  1.00 18.11 ? 323 GLU B O   1 
ATOM   1492 C CB  . GLU B 1 70  ? 23.028 -43.451 15.148  1.00 19.25 ? 323 GLU B CB  1 
ATOM   1493 C CG  . GLU B 1 70  ? 24.235 -42.876 14.433  1.00 22.68 ? 323 GLU B CG  1 
ATOM   1494 C CD  . GLU B 1 70  ? 24.988 -41.832 15.242  1.00 26.38 ? 323 GLU B CD  1 
ATOM   1495 O OE1 . GLU B 1 70  ? 26.073 -41.413 14.789  1.00 28.76 ? 323 GLU B OE1 1 
ATOM   1496 O OE2 . GLU B 1 70  ? 24.479 -41.405 16.306  1.00 29.92 ? 323 GLU B OE2 1 
ATOM   1497 N N   . VAL B 1 71  ? 21.470 -46.397 15.520  1.00 16.17 ? 324 VAL B N   1 
ATOM   1498 C CA  . VAL B 1 71  ? 20.605 -47.143 16.410  1.00 16.08 ? 324 VAL B CA  1 
ATOM   1499 C C   . VAL B 1 71  ? 21.364 -47.308 17.711  1.00 16.15 ? 324 VAL B C   1 
ATOM   1500 O O   . VAL B 1 71  ? 22.473 -47.840 17.715  1.00 17.11 ? 324 VAL B O   1 
ATOM   1501 C CB  . VAL B 1 71  ? 20.209 -48.501 15.810  1.00 17.32 ? 324 VAL B CB  1 
ATOM   1502 C CG1 . VAL B 1 71  ? 19.319 -49.281 16.760  1.00 18.73 ? 324 VAL B CG1 1 
ATOM   1503 C CG2 . VAL B 1 71  ? 19.558 -48.316 14.445  1.00 17.31 ? 324 VAL B CG2 1 
ATOM   1504 N N   . THR B 1 72  ? 20.790 -46.806 18.801  1.00 15.83 ? 325 THR B N   1 
ATOM   1505 C CA  . THR B 1 72  ? 21.490 -46.752 20.072  1.00 16.76 ? 325 THR B CA  1 
ATOM   1506 C C   . THR B 1 72  ? 20.515 -47.189 21.157  1.00 15.04 ? 325 THR B C   1 
ATOM   1507 O O   . THR B 1 72  ? 19.339 -47.384 20.893  1.00 15.31 ? 325 THR B O   1 
ATOM   1508 C CB  . THR B 1 72  ? 22.031 -45.346 20.357  1.00 16.81 ? 325 THR B CB  1 
ATOM   1509 O OG1 . THR B 1 72  ? 20.942 -44.580 20.861  1.00 17.49 ? 325 THR B OG1 1 
ATOM   1510 C CG2 . THR B 1 72  ? 22.599 -44.652 19.135  1.00 17.90 ? 325 THR B CG2 1 
ATOM   1511 N N   . PRO B 1 73  ? 20.950 -47.310 22.428  1.00 16.42 ? 326 PRO B N   1 
ATOM   1512 C CA  . PRO B 1 73  ? 20.015 -47.653 23.490  1.00 15.63 ? 326 PRO B CA  1 
ATOM   1513 C C   . PRO B 1 73  ? 18.839 -46.696 23.661  1.00 14.95 ? 326 PRO B C   1 
ATOM   1514 O O   . PRO B 1 73  ? 17.812 -47.085 24.198  1.00 17.51 ? 326 PRO B O   1 
ATOM   1515 C CB  . PRO B 1 73  ? 20.919 -47.679 24.732  1.00 16.36 ? 326 PRO B CB  1 
ATOM   1516 C CG  . PRO B 1 73  ? 22.283 -48.020 24.186  1.00 17.49 ? 326 PRO B CG  1 
ATOM   1517 C CD  . PRO B 1 73  ? 22.351 -47.278 22.875  1.00 16.97 ? 326 PRO B CD  1 
ATOM   1518 N N   . SER B 1 74  ? 18.960 -45.445 23.209  1.00 14.27 ? 327 SER B N   1 
ATOM   1519 C CA  . SER B 1 74  ? 17.866 -44.492 23.338  1.00 15.21 ? 327 SER B CA  1 
ATOM   1520 C C   . SER B 1 74  ? 16.890 -44.550 22.175  1.00 15.10 ? 327 SER B C   1 
ATOM   1521 O O   . SER B 1 74  ? 15.837 -43.929 22.238  1.00 17.72 ? 327 SER B O   1 
ATOM   1522 C CB  . SER B 1 74  ? 18.380 -43.094 23.485  1.00 15.36 ? 327 SER B CB  1 
ATOM   1523 O OG  . SER B 1 74  ? 19.216 -42.769 22.376  1.00 15.43 ? 327 SER B OG  1 
ATOM   1524 N N   . GLY B 1 75  ? 17.269 -45.217 21.084  1.00 14.50 ? 328 GLY B N   1 
ATOM   1525 C CA  . GLY B 1 75  ? 16.392 -45.329 19.941  1.00 14.28 ? 328 GLY B CA  1 
ATOM   1526 C C   . GLY B 1 75  ? 17.143 -45.220 18.619  1.00 13.51 ? 328 GLY B C   1 
ATOM   1527 O O   . GLY B 1 75  ? 18.352 -45.445 18.562  1.00 14.71 ? 328 GLY B O   1 
ATOM   1528 N N   . THR B 1 76  ? 16.377 -44.912 17.580  1.00 13.57 ? 329 THR B N   1 
ATOM   1529 C CA  . THR B 1 76  ? 16.900 -44.780 16.241  1.00 13.67 ? 329 THR B CA  1 
ATOM   1530 C C   . THR B 1 76  ? 16.884 -43.305 15.869  1.00 13.63 ? 329 THR B C   1 
ATOM   1531 O O   . THR B 1 76  ? 15.861 -42.637 16.004  1.00 14.09 ? 329 THR B O   1 
ATOM   1532 C CB  . THR B 1 76  ? 16.066 -45.587 15.251  1.00 14.33 ? 329 THR B CB  1 
ATOM   1533 O OG1 . THR B 1 76  ? 16.146 -46.957 15.639  1.00 16.17 ? 329 THR B OG1 1 
ATOM   1534 C CG2 . THR B 1 76  ? 16.560 -45.467 13.832  1.00 15.49 ? 329 THR B CG2 1 
ATOM   1535 N N   . TRP B 1 77  ? 18.038 -42.814 15.420  1.00 12.85 ? 330 TRP B N   1 
ATOM   1536 C CA  . TRP B 1 77  ? 18.261 -41.397 15.206  1.00 13.47 ? 330 TRP B CA  1 
ATOM   1537 C C   . TRP B 1 77  ? 18.691 -41.147 13.770  1.00 13.32 ? 330 TRP B C   1 
ATOM   1538 O O   . TRP B 1 77  ? 19.565 -41.839 13.255  1.00 15.52 ? 330 TRP B O   1 
ATOM   1539 C CB  . TRP B 1 77  ? 19.341 -40.892 16.150  1.00 13.51 ? 330 TRP B CB  1 
ATOM   1540 C CG  . TRP B 1 77  ? 19.022 -41.025 17.606  1.00 13.46 ? 330 TRP B CG  1 
ATOM   1541 C CD1 . TRP B 1 77  ? 19.097 -42.151 18.374  1.00 14.79 ? 330 TRP B CD1 1 
ATOM   1542 C CD2 . TRP B 1 77  ? 18.558 -39.969 18.465  1.00 13.74 ? 330 TRP B CD2 1 
ATOM   1543 N NE1 . TRP B 1 77  ? 18.711 -41.867 19.654  1.00 14.60 ? 330 TRP B NE1 1 
ATOM   1544 C CE2 . TRP B 1 77  ? 18.429 -40.536 19.753  1.00 14.24 ? 330 TRP B CE2 1 
ATOM   1545 C CE3 . TRP B 1 77  ? 18.322 -38.599 18.295  1.00 14.15 ? 330 TRP B CE3 1 
ATOM   1546 C CZ2 . TRP B 1 77  ? 18.038 -39.779 20.854  1.00 14.74 ? 330 TRP B CZ2 1 
ATOM   1547 C CZ3 . TRP B 1 77  ? 17.943 -37.852 19.389  1.00 14.92 ? 330 TRP B CZ3 1 
ATOM   1548 C CH2 . TRP B 1 77  ? 17.768 -38.449 20.636  1.00 15.34 ? 330 TRP B CH2 1 
ATOM   1549 N N   A LEU B 1 78  ? 18.084 -40.142 13.141  0.50 12.65 ? 331 LEU B N   1 
ATOM   1550 N N   B LEU B 1 78  ? 18.087 -40.139 13.144  0.50 12.76 ? 331 LEU B N   1 
ATOM   1551 C CA  A LEU B 1 78  ? 18.547 -39.643 11.859  0.50 12.77 ? 331 LEU B CA  1 
ATOM   1552 C CA  B LEU B 1 78  ? 18.542 -39.641 11.861  0.50 12.98 ? 331 LEU B CA  1 
ATOM   1553 C C   A LEU B 1 78  ? 19.560 -38.539 12.133  0.50 13.10 ? 331 LEU B C   1 
ATOM   1554 C C   B LEU B 1 78  ? 19.560 -38.537 12.131  0.50 13.21 ? 331 LEU B C   1 
ATOM   1555 O O   A LEU B 1 78  ? 19.210 -37.511 12.714  0.50 14.76 ? 331 LEU B O   1 
ATOM   1556 O O   B LEU B 1 78  ? 19.223 -37.517 12.734  0.50 14.85 ? 331 LEU B O   1 
ATOM   1557 C CB  A LEU B 1 78  ? 17.341 -39.131 11.064  0.50 12.91 ? 331 LEU B CB  1 
ATOM   1558 C CB  B LEU B 1 78  ? 17.329 -39.113 11.093  0.50 13.30 ? 331 LEU B CB  1 
ATOM   1559 C CG  A LEU B 1 78  ? 17.658 -38.496 9.712   0.50 14.12 ? 331 LEU B CG  1 
ATOM   1560 C CG  B LEU B 1 78  ? 17.582 -38.726 9.640   0.50 14.73 ? 331 LEU B CG  1 
ATOM   1561 C CD1 A LEU B 1 78  ? 16.498 -38.685 8.753   0.50 15.06 ? 331 LEU B CD1 1 
ATOM   1562 C CD1 B LEU B 1 78  ? 17.851 -39.965 8.803   0.50 15.34 ? 331 LEU B CD1 1 
ATOM   1563 C CD2 A LEU B 1 78  ? 18.019 -37.025 9.876   0.50 14.60 ? 331 LEU B CD2 1 
ATOM   1564 C CD2 B LEU B 1 78  ? 16.410 -37.935 9.094   0.50 15.38 ? 331 LEU B CD2 1 
ATOM   1565 N N   . THR B 1 79  ? 20.813 -38.753 11.734  1.00 12.77 ? 332 THR B N   1 
ATOM   1566 C CA  . THR B 1 79  ? 21.850 -37.748 11.909  1.00 12.51 ? 332 THR B CA  1 
ATOM   1567 C C   . THR B 1 79  ? 21.950 -36.888 10.664  1.00 11.99 ? 332 THR B C   1 
ATOM   1568 O O   . THR B 1 79  ? 21.675 -37.325 9.550   1.00 11.66 ? 332 THR B O   1 
ATOM   1569 C CB  . THR B 1 79  ? 23.185 -38.414 12.234  1.00 13.91 ? 332 THR B CB  1 
ATOM   1570 O OG1 . THR B 1 79  ? 23.551 -39.184 11.089  1.00 15.40 ? 332 THR B OG1 1 
ATOM   1571 C CG2 . THR B 1 79  ? 23.110 -39.277 13.475  1.00 15.71 ? 332 THR B CG2 1 
ATOM   1572 N N   . TYR B 1 80  ? 22.361 -35.642 10.861  1.00 11.44 ? 333 TYR B N   1 
ATOM   1573 C CA  . TYR B 1 80  ? 22.520 -34.729 9.740   1.00 12.13 ? 333 TYR B CA  1 
ATOM   1574 C C   . TYR B 1 80  ? 23.669 -33.780 10.020  1.00 11.80 ? 333 TYR B C   1 
ATOM   1575 O O   . TYR B 1 80  ? 23.874 -33.353 11.150  1.00 12.13 ? 333 TYR B O   1 
ATOM   1576 C CB  . TYR B 1 80  ? 21.232 -33.951 9.484   1.00 12.46 ? 333 TYR B CB  1 
ATOM   1577 C CG  . TYR B 1 80  ? 20.771 -33.079 10.621  1.00 11.79 ? 333 TYR B CG  1 
ATOM   1578 C CD1 . TYR B 1 80  ? 19.949 -33.573 11.620  1.00 11.72 ? 333 TYR B CD1 1 
ATOM   1579 C CD2 . TYR B 1 80  ? 21.175 -31.756 10.716  1.00 12.19 ? 333 TYR B CD2 1 
ATOM   1580 C CE1 . TYR B 1 80  ? 19.549 -32.770 12.678  1.00 12.15 ? 333 TYR B CE1 1 
ATOM   1581 C CE2 . TYR B 1 80  ? 20.751 -30.934 11.746  1.00 11.93 ? 333 TYR B CE2 1 
ATOM   1582 C CZ  . TYR B 1 80  ? 19.954 -31.448 12.741  1.00 11.51 ? 333 TYR B CZ  1 
ATOM   1583 O OH  . TYR B 1 80  ? 19.526 -30.676 13.792  1.00 12.53 ? 333 TYR B OH  1 
ATOM   1584 N N   A THR B 1 81  ? 24.433 -33.476 8.979   0.50 12.76 ? 334 THR B N   1 
ATOM   1585 N N   B THR B 1 81  ? 24.428 -33.472 8.976   0.50 12.02 ? 334 THR B N   1 
ATOM   1586 C CA  A THR B 1 81  ? 25.473 -32.467 9.044   0.50 13.31 ? 334 THR B CA  1 
ATOM   1587 C CA  B THR B 1 81  ? 25.487 -32.483 9.038   0.50 11.96 ? 334 THR B CA  1 
ATOM   1588 C C   A THR B 1 81  ? 25.534 -31.766 7.699   0.50 13.13 ? 334 THR B C   1 
ATOM   1589 C C   B THR B 1 81  ? 25.544 -31.771 7.699   0.50 12.46 ? 334 THR B C   1 
ATOM   1590 O O   A THR B 1 81  ? 25.266 -32.349 6.657   0.50 13.63 ? 334 THR B O   1 
ATOM   1591 O O   B THR B 1 81  ? 25.281 -32.356 6.657   0.50 13.22 ? 334 THR B O   1 
ATOM   1592 C CB  A THR B 1 81  ? 26.862 -33.035 9.358   0.50 15.42 ? 334 THR B CB  1 
ATOM   1593 C CB  B THR B 1 81  ? 26.848 -33.125 9.318   0.50 12.58 ? 334 THR B CB  1 
ATOM   1594 O OG1 A THR B 1 81  ? 27.326 -33.818 8.258   0.50 17.37 ? 334 THR B OG1 1 
ATOM   1595 O OG1 B THR B 1 81  ? 26.734 -33.869 10.528  0.50 13.81 ? 334 THR B OG1 1 
ATOM   1596 C CG2 A THR B 1 81  ? 26.899 -33.857 10.622  0.50 16.11 ? 334 THR B CG2 1 
ATOM   1597 C CG2 B THR B 1 81  ? 27.977 -32.123 9.428   0.50 11.90 ? 334 THR B CG2 1 
ATOM   1598 N N   . GLY B 1 82  ? 25.887 -30.492 7.719   1.00 12.14 ? 335 GLY B N   1 
ATOM   1599 C CA  . GLY B 1 82  ? 26.125 -29.782 6.486   1.00 12.27 ? 335 GLY B CA  1 
ATOM   1600 C C   . GLY B 1 82  ? 26.622 -28.382 6.753   1.00 11.98 ? 335 GLY B C   1 
ATOM   1601 O O   . GLY B 1 82  ? 26.970 -28.034 7.876   1.00 12.62 ? 335 GLY B O   1 
ATOM   1602 N N   . ALA B 1 83  ? 26.673 -27.607 5.679   1.00 13.15 ? 336 ALA B N   1 
ATOM   1603 C CA  . ALA B 1 83  ? 27.152 -26.245 5.765   1.00 13.96 ? 336 ALA B CA  1 
ATOM   1604 C C   . ALA B 1 83  ? 26.466 -25.429 4.690   1.00 14.71 ? 336 ALA B C   1 
ATOM   1605 O O   . ALA B 1 83  ? 26.224 -25.931 3.594   1.00 16.83 ? 336 ALA B O   1 
ATOM   1606 C CB  . ALA B 1 83  ? 28.649 -26.180 5.619   1.00 14.48 ? 336 ALA B CB  1 
ATOM   1607 N N   . ILE B 1 84  ? 26.173 -24.174 5.026   1.00 13.95 ? 337 ILE B N   1 
ATOM   1608 C CA  . ILE B 1 84  ? 25.480 -23.248 4.151   1.00 14.83 ? 337 ILE B CA  1 
ATOM   1609 C C   . ILE B 1 84  ? 26.350 -22.020 3.991   1.00 15.67 ? 337 ILE B C   1 
ATOM   1610 O O   . ILE B 1 84  ? 26.679 -21.368 4.964   1.00 15.35 ? 337 ILE B O   1 
ATOM   1611 C CB  . ILE B 1 84  ? 24.115 -22.911 4.763   1.00 14.94 ? 337 ILE B CB  1 
ATOM   1612 C CG1 . ILE B 1 84  ? 23.211 -24.152 4.761   1.00 15.86 ? 337 ILE B CG1 1 
ATOM   1613 C CG2 . ILE B 1 84  ? 23.461 -21.736 4.059   1.00 15.45 ? 337 ILE B CG2 1 
ATOM   1614 C CD1 . ILE B 1 84  ? 22.076 -24.090 5.732   1.00 16.73 ? 337 ILE B CD1 1 
ATOM   1615 N N   . LYS B 1 85  ? 26.700 -21.689 2.752   1.00 15.26 ? 338 LYS B N   1 
ATOM   1616 C CA  . LYS B 1 85  ? 27.581 -20.566 2.489   1.00 16.05 ? 338 LYS B CA  1 
ATOM   1617 C C   . LYS B 1 85  ? 26.794 -19.259 2.558   1.00 15.91 ? 338 LYS B C   1 
ATOM   1618 O O   . LYS B 1 85  ? 25.736 -19.127 1.946   1.00 16.98 ? 338 LYS B O   1 
ATOM   1619 C CB  . LYS B 1 85  ? 28.238 -20.701 1.117   1.00 17.17 ? 338 LYS B CB  1 
ATOM   1620 C CG  . LYS B 1 85  ? 29.444 -19.794 0.940   1.00 18.81 ? 338 LYS B CG  1 
ATOM   1621 C CD  . LYS B 1 85  ? 30.105 -19.919 -0.412  1.00 21.01 ? 338 LYS B CD  1 
ATOM   1622 C CE  . LYS B 1 85  ? 31.415 -19.165 -0.484  1.00 24.16 ? 338 LYS B CE  1 
ATOM   1623 N NZ  . LYS B 1 85  ? 31.212 -17.698 -0.522  1.00 25.60 ? 338 LYS B NZ  1 
ATOM   1624 N N   . LEU B 1 86  ? 27.320 -18.296 3.313   1.00 15.55 ? 339 LEU B N   1 
ATOM   1625 C CA  . LEU B 1 86  ? 26.764 -16.945 3.329   1.00 16.76 ? 339 LEU B CA  1 
ATOM   1626 C C   . LEU B 1 86  ? 27.168 -16.256 2.033   1.00 17.32 ? 339 LEU B C   1 
ATOM   1627 O O   . LEU B 1 86  ? 28.229 -16.543 1.479   1.00 18.29 ? 339 LEU B O   1 
ATOM   1628 C CB  . LEU B 1 86  ? 27.262 -16.182 4.556   1.00 17.71 ? 339 LEU B CB  1 
ATOM   1629 C CG  . LEU B 1 86  ? 26.423 -16.349 5.823   1.00 18.95 ? 339 LEU B CG  1 
ATOM   1630 C CD1 . LEU B 1 86  ? 26.499 -17.766 6.352   1.00 19.24 ? 339 LEU B CD1 1 
ATOM   1631 C CD2 . LEU B 1 86  ? 26.896 -15.365 6.879   1.00 19.64 ? 339 LEU B CD2 1 
ATOM   1632 N N   . ASP B 1 87  ? 26.293 -15.365 1.555   1.00 17.96 ? 340 ASP B N   1 
ATOM   1633 C CA  . ASP B 1 87  ? 26.525 -14.674 0.295   1.00 21.14 ? 340 ASP B CA  1 
ATOM   1634 C C   . ASP B 1 87  ? 27.332 -13.408 0.575   1.00 23.31 ? 340 ASP B C   1 
ATOM   1635 O O   . ASP B 1 87  ? 26.780 -12.429 1.057   1.00 21.72 ? 340 ASP B O   1 
ATOM   1636 C CB  . ASP B 1 87  ? 25.194 -14.358 -0.385  1.00 23.73 ? 340 ASP B CB  1 
ATOM   1637 C CG  . ASP B 1 87  ? 25.337 -13.659 -1.731  1.00 26.57 ? 340 ASP B CG  1 
ATOM   1638 O OD1 . ASP B 1 87  ? 24.311 -13.377 -2.355  1.00 32.76 ? 340 ASP B OD1 1 
ATOM   1639 O OD2 . ASP B 1 87  ? 26.481 -13.404 -2.135  1.00 28.25 ? 340 ASP B OD2 1 
ATOM   1640 N N   A ASP B 1 88  ? 28.639 -13.446 0.292   0.50 26.77 ? 341 ASP B N   1 
ATOM   1641 N N   B ASP B 1 88  ? 28.638 -13.448 0.287   0.50 27.04 ? 341 ASP B N   1 
ATOM   1642 C CA  A ASP B 1 88  ? 29.530 -12.344 0.619   0.50 29.82 ? 341 ASP B CA  1 
ATOM   1643 C CA  B ASP B 1 88  ? 29.536 -12.351 0.614   0.50 30.35 ? 341 ASP B CA  1 
ATOM   1644 C C   A ASP B 1 88  ? 29.254 -11.127 -0.270  0.50 30.19 ? 341 ASP B C   1 
ATOM   1645 C C   B ASP B 1 88  ? 29.256 -11.130 -0.270  0.50 30.48 ? 341 ASP B C   1 
ATOM   1646 O O   A ASP B 1 88  ? 29.758 -10.044 0.034   0.50 32.46 ? 341 ASP B O   1 
ATOM   1647 O O   B ASP B 1 88  ? 29.766 -10.050 0.028   0.50 32.73 ? 341 ASP B O   1 
ATOM   1648 C CB  A ASP B 1 88  ? 30.999 -12.761 0.485   0.50 32.65 ? 341 ASP B CB  1 
ATOM   1649 C CB  B ASP B 1 88  ? 30.997 -12.791 0.464   0.50 33.62 ? 341 ASP B CB  1 
ATOM   1650 C CG  A ASP B 1 88  ? 31.264 -13.797 -0.593  0.50 33.44 ? 341 ASP B CG  1 
ATOM   1651 C CG  B ASP B 1 88  ? 31.372 -13.153 -0.961  0.50 35.17 ? 341 ASP B CG  1 
ATOM   1652 O OD1 A ASP B 1 88  ? 30.946 -13.539 -1.768  0.50 37.57 ? 341 ASP B OD1 1 
ATOM   1653 O OD1 B ASP B 1 88  ? 30.665 -13.997 -1.551  0.50 38.57 ? 341 ASP B OD1 1 
ATOM   1654 O OD2 A ASP B 1 88  ? 31.809 -14.862 -0.242  0.50 37.25 ? 341 ASP B OD2 1 
ATOM   1655 O OD2 B ASP B 1 88  ? 32.348 -12.572 -1.473  0.50 39.28 ? 341 ASP B OD2 1 
ATOM   1656 N N   . LYS B 1 89  ? 28.445 -11.295 -1.329  1.00 29.73 ? 342 LYS B N   1 
ATOM   1657 C CA  . LYS B 1 89  ? 28.049 -10.192 -2.198  1.00 32.39 ? 342 LYS B CA  1 
ATOM   1658 C C   . LYS B 1 89  ? 26.823 -9.452  -1.656  1.00 30.72 ? 342 LYS B C   1 
ATOM   1659 O O   . LYS B 1 89  ? 26.499 -8.365  -2.132  1.00 29.70 ? 342 LYS B O   1 
ATOM   1660 C CB  . LYS B 1 89  ? 27.700 -10.699 -3.598  1.00 35.02 ? 342 LYS B CB  1 
ATOM   1661 C CG  . LYS B 1 89  ? 28.855 -11.335 -4.352  1.00 38.43 ? 342 LYS B CG  1 
ATOM   1662 C CD  . LYS B 1 89  ? 28.522 -11.589 -5.819  1.00 43.07 ? 342 LYS B CD  1 
ATOM   1663 C CE  . LYS B 1 89  ? 29.719 -12.017 -6.643  1.00 45.62 ? 342 LYS B CE  1 
ATOM   1664 N NZ  . LYS B 1 89  ? 30.236 -13.338 -6.218  1.00 46.25 ? 342 LYS B NZ  1 
ATOM   1665 N N   . ASP B 1 90  ? 26.131 -10.050 -0.686  1.00 25.64 ? 343 ASP B N   1 
ATOM   1666 C CA  . ASP B 1 90  ? 25.025 -9.381  -0.026  1.00 24.56 ? 343 ASP B CA  1 
ATOM   1667 C C   . ASP B 1 90  ? 25.566 -8.220  0.799   1.00 23.12 ? 343 ASP B C   1 
ATOM   1668 O O   . ASP B 1 90  ? 26.431 -8.407  1.640   1.00 24.16 ? 343 ASP B O   1 
ATOM   1669 C CB  . ASP B 1 90  ? 24.254 -10.386 0.836   1.00 25.57 ? 343 ASP B CB  1 
ATOM   1670 C CG  . ASP B 1 90  ? 22.925 -9.882  1.370   1.00 28.14 ? 343 ASP B CG  1 
ATOM   1671 O OD1 . ASP B 1 90  ? 22.063 -10.741 1.663   1.00 30.84 ? 343 ASP B OD1 1 
ATOM   1672 O OD2 . ASP B 1 90  ? 22.773 -8.660  1.498   1.00 29.03 ? 343 ASP B OD2 1 
ATOM   1673 N N   . PRO B 1 91  ? 25.089 -6.966  0.607   1.00 24.76 ? 344 PRO B N   1 
ATOM   1674 C CA  . PRO B 1 91  ? 25.583 -5.867  1.437   1.00 24.82 ? 344 PRO B CA  1 
ATOM   1675 C C   . PRO B 1 91  ? 25.282 -6.085  2.921   1.00 23.24 ? 344 PRO B C   1 
ATOM   1676 O O   . PRO B 1 91  ? 25.922 -5.489  3.765   1.00 25.60 ? 344 PRO B O   1 
ATOM   1677 C CB  . PRO B 1 91  ? 24.877 -4.624  0.878   1.00 26.19 ? 344 PRO B CB  1 
ATOM   1678 C CG  . PRO B 1 91  ? 23.666 -5.168  0.162   1.00 27.87 ? 344 PRO B CG  1 
ATOM   1679 C CD  . PRO B 1 91  ? 24.085 -6.531  -0.381  1.00 25.69 ? 344 PRO B CD  1 
ATOM   1680 N N   . ASN B 1 92  ? 24.328 -6.966  3.221   1.00 24.02 ? 345 ASN B N   1 
ATOM   1681 C CA  . ASN B 1 92  ? 23.949 -7.299  4.586   1.00 24.82 ? 345 ASN B CA  1 
ATOM   1682 C C   . ASN B 1 92  ? 24.817 -8.424  5.165   1.00 23.56 ? 345 ASN B C   1 
ATOM   1683 O O   . ASN B 1 92  ? 24.581 -8.849  6.291   1.00 24.49 ? 345 ASN B O   1 
ATOM   1684 C CB  . ASN B 1 92  ? 22.477 -7.718  4.655   1.00 27.44 ? 345 ASN B CB  1 
ATOM   1685 C CG  . ASN B 1 92  ? 21.531 -6.643  4.156   1.00 31.83 ? 345 ASN B CG  1 
ATOM   1686 O OD1 . ASN B 1 92  ? 21.619 -5.507  4.609   1.00 35.57 ? 345 ASN B OD1 1 
ATOM   1687 N ND2 . ASN B 1 92  ? 20.672 -6.972  3.201   1.00 33.51 ? 345 ASN B ND2 1 
ATOM   1688 N N   . PHE B 1 93  ? 25.853 -8.868  4.438   1.00 22.57 ? 346 PHE B N   1 
ATOM   1689 C CA  . PHE B 1 93  ? 26.700 -9.979  4.855   1.00 22.49 ? 346 PHE B CA  1 
ATOM   1690 C C   . PHE B 1 93  ? 27.292 -9.748  6.237   1.00 23.71 ? 346 PHE B C   1 
ATOM   1691 O O   . PHE B 1 93  ? 27.220 -10.631 7.076   1.00 22.06 ? 346 PHE B O   1 
ATOM   1692 C CB  . PHE B 1 93  ? 27.832 -10.182 3.844   1.00 21.21 ? 346 PHE B CB  1 
ATOM   1693 C CG  . PHE B 1 93  ? 28.894 -11.169 4.251   1.00 21.29 ? 346 PHE B CG  1 
ATOM   1694 C CD1 . PHE B 1 93  ? 30.101 -10.756 4.781   1.00 22.75 ? 346 PHE B CD1 1 
ATOM   1695 C CD2 . PHE B 1 93  ? 28.684 -12.522 4.103   1.00 23.11 ? 346 PHE B CD2 1 
ATOM   1696 C CE1 . PHE B 1 93  ? 31.076 -11.671 5.153   1.00 23.89 ? 346 PHE B CE1 1 
ATOM   1697 C CE2 . PHE B 1 93  ? 29.675 -13.439 4.432   1.00 23.11 ? 346 PHE B CE2 1 
ATOM   1698 C CZ  . PHE B 1 93  ? 30.854 -13.018 4.987   1.00 23.80 ? 346 PHE B CZ  1 
ATOM   1699 N N   . LYS B 1 94  ? 27.908 -8.582  6.489   1.00 23.13 ? 347 LYS B N   1 
ATOM   1700 C CA  . LYS B 1 94  ? 28.588 -8.368  7.754   1.00 25.72 ? 347 LYS B CA  1 
ATOM   1701 C C   . LYS B 1 94  ? 27.587 -8.456  8.902   1.00 23.68 ? 347 LYS B C   1 
ATOM   1702 O O   . LYS B 1 94  ? 27.917 -8.999  9.944   1.00 23.62 ? 347 LYS B O   1 
ATOM   1703 C CB  . LYS B 1 94  ? 29.294 -7.011  7.764   1.00 29.90 ? 347 LYS B CB  1 
ATOM   1704 C CG  . LYS B 1 94  ? 30.563 -6.938  6.940   1.00 32.24 ? 347 LYS B CG  1 
ATOM   1705 C CD  . LYS B 1 94  ? 31.342 -5.652  7.196   1.00 33.31 ? 347 LYS B CD  1 
ATOM   1706 C CE  . LYS B 1 94  ? 30.521 -4.378  7.092   1.00 34.39 ? 347 LYS B CE  1 
ATOM   1707 N NZ  . LYS B 1 94  ? 29.937 -4.195  5.739   1.00 35.42 ? 347 LYS B NZ  1 
ATOM   1708 N N   . ASP B 1 95  ? 26.379 -7.929  8.686   1.00 21.32 ? 348 ASP B N   1 
ATOM   1709 C CA  . ASP B 1 95  ? 25.327 -7.952  9.687   1.00 23.10 ? 348 ASP B CA  1 
ATOM   1710 C C   . ASP B 1 95  ? 24.855 -9.386  9.919   1.00 22.10 ? 348 ASP B C   1 
ATOM   1711 O O   . ASP B 1 95  ? 24.484 -9.749  11.031  1.00 21.02 ? 348 ASP B O   1 
ATOM   1712 C CB  . ASP B 1 95  ? 24.144 -7.072  9.272   1.00 26.80 ? 348 ASP B CB  1 
ATOM   1713 C CG  . ASP B 1 95  ? 24.372 -5.578  9.431   1.00 30.90 ? 348 ASP B CG  1 
ATOM   1714 O OD1 . ASP B 1 95  ? 25.352 -5.203  10.110  1.00 33.55 ? 348 ASP B OD1 1 
ATOM   1715 O OD2 . ASP B 1 95  ? 23.566 -4.808  8.869   1.00 37.08 ? 348 ASP B OD2 1 
ATOM   1716 N N   . GLN B 1 96  ? 24.822 -10.198 8.865   1.00 19.75 ? 349 GLN B N   1 
ATOM   1717 C CA  . GLN B 1 96  ? 24.396 -11.583 9.009   1.00 19.75 ? 349 GLN B CA  1 
ATOM   1718 C C   . GLN B 1 96  ? 25.394 -12.363 9.850   1.00 19.56 ? 349 GLN B C   1 
ATOM   1719 O O   . GLN B 1 96  ? 25.007 -13.159 10.719  1.00 18.94 ? 349 GLN B O   1 
ATOM   1720 C CB  . GLN B 1 96  ? 24.262 -12.214 7.634   1.00 19.77 ? 349 GLN B CB  1 
ATOM   1721 C CG  . GLN B 1 96  ? 23.095 -11.658 6.854   1.00 20.91 ? 349 GLN B CG  1 
ATOM   1722 C CD  . GLN B 1 96  ? 23.198 -11.948 5.383   1.00 21.82 ? 349 GLN B CD  1 
ATOM   1723 O OE1 . GLN B 1 96  ? 24.107 -12.642 4.930   1.00 23.87 ? 349 GLN B OE1 1 
ATOM   1724 N NE2 . GLN B 1 96  ? 22.219 -11.462 4.641   1.00 21.71 ? 349 GLN B NE2 1 
ATOM   1725 N N   . VAL B 1 97  ? 26.687 -12.134 9.610   1.00 19.39 ? 350 VAL B N   1 
ATOM   1726 C CA  . VAL B 1 97  ? 27.721 -12.789 10.385  1.00 19.95 ? 350 VAL B CA  1 
ATOM   1727 C C   . VAL B 1 97  ? 27.543 -12.411 11.853  1.00 21.17 ? 350 VAL B C   1 
ATOM   1728 O O   . VAL B 1 97  ? 27.593 -13.265 12.726  1.00 19.84 ? 350 VAL B O   1 
ATOM   1729 C CB  . VAL B 1 97  ? 29.127 -12.435 9.858   1.00 21.88 ? 350 VAL B CB  1 
ATOM   1730 C CG1 . VAL B 1 97  ? 30.218 -12.919 10.783  1.00 22.52 ? 350 VAL B CG1 1 
ATOM   1731 C CG2 . VAL B 1 97  ? 29.363 -12.961 8.447   1.00 22.21 ? 350 VAL B CG2 1 
ATOM   1732 N N   . ILE B 1 98  ? 27.340 -11.120 12.116  1.00 20.00 ? 351 ILE B N   1 
ATOM   1733 C CA  . ILE B 1 98  ? 27.184 -10.629 13.474  1.00 21.43 ? 351 ILE B CA  1 
ATOM   1734 C C   . ILE B 1 98  ? 25.965 -11.264 14.129  1.00 18.95 ? 351 ILE B C   1 
ATOM   1735 O O   . ILE B 1 98  ? 26.069 -11.666 15.282  1.00 19.61 ? 351 ILE B O   1 
ATOM   1736 C CB  . ILE B 1 98  ? 27.142 -9.088  13.493  1.00 24.41 ? 351 ILE B CB  1 
ATOM   1737 C CG1 . ILE B 1 98  ? 28.552 -8.535  13.264  1.00 26.91 ? 351 ILE B CG1 1 
ATOM   1738 C CG2 . ILE B 1 98  ? 26.534 -8.545  14.777  1.00 24.61 ? 351 ILE B CG2 1 
ATOM   1739 C CD1 . ILE B 1 98  ? 28.598 -7.087  12.832  1.00 27.71 ? 351 ILE B CD1 1 
ATOM   1740 N N   . LEU B 1 99  ? 24.834 -11.308 13.429  1.00 17.44 ? 352 LEU B N   1 
ATOM   1741 C CA  . LEU B 1 99  ? 23.611 -11.815 14.043  1.00 17.73 ? 352 LEU B CA  1 
ATOM   1742 C C   . LEU B 1 99  ? 23.784 -13.300 14.374  1.00 17.73 ? 352 LEU B C   1 
ATOM   1743 O O   . LEU B 1 99  ? 23.417 -13.741 15.474  1.00 19.84 ? 352 LEU B O   1 
ATOM   1744 C CB  . LEU B 1 99  ? 22.414 -11.580 13.123  1.00 17.72 ? 352 LEU B CB  1 
ATOM   1745 C CG  . LEU B 1 99  ? 21.104 -12.287 13.504  1.00 20.54 ? 352 LEU B CG  1 
ATOM   1746 C CD1 . LEU B 1 99  ? 20.526 -11.829 14.854  1.00 21.24 ? 352 LEU B CD1 1 
ATOM   1747 C CD2 . LEU B 1 99  ? 20.079 -12.137 12.401  1.00 22.54 ? 352 LEU B CD2 1 
ATOM   1748 N N   . LEU B 1 100 ? 24.371 -14.076 13.462  1.00 16.86 ? 353 LEU B N   1 
ATOM   1749 C CA  . LEU B 1 100 ? 24.520 -15.493 13.727  1.00 16.23 ? 353 LEU B CA  1 
ATOM   1750 C C   . LEU B 1 100 ? 25.472 -15.699 14.905  1.00 16.92 ? 353 LEU B C   1 
ATOM   1751 O O   . LEU B 1 100 ? 25.207 -16.483 15.824  1.00 16.56 ? 353 LEU B O   1 
ATOM   1752 C CB  . LEU B 1 100 ? 24.997 -16.179 12.445  1.00 15.61 ? 353 LEU B CB  1 
ATOM   1753 C CG  . LEU B 1 100 ? 23.947 -16.255 11.352  1.00 16.22 ? 353 LEU B CG  1 
ATOM   1754 C CD1 . LEU B 1 100 ? 24.582 -16.634 10.015  1.00 16.61 ? 353 LEU B CD1 1 
ATOM   1755 C CD2 . LEU B 1 100 ? 22.865 -17.258 11.735  1.00 16.98 ? 353 LEU B CD2 1 
ATOM   1756 N N   . ASN B 1 101 ? 26.583 -14.958 14.914  1.00 17.81 ? 354 ASN B N   1 
ATOM   1757 C CA  . ASN B 1 101 ? 27.574 -15.108 15.961  1.00 18.61 ? 354 ASN B CA  1 
ATOM   1758 C C   . ASN B 1 101 ? 27.026 -14.659 17.306  1.00 18.15 ? 354 ASN B C   1 
ATOM   1759 O O   . ASN B 1 101 ? 27.470 -15.188 18.326  1.00 20.84 ? 354 ASN B O   1 
ATOM   1760 C CB  . ASN B 1 101 ? 28.881 -14.420 15.581  1.00 20.77 ? 354 ASN B CB  1 
ATOM   1761 C CG  . ASN B 1 101 ? 29.696 -15.261 14.613  1.00 23.17 ? 354 ASN B CG  1 
ATOM   1762 O OD1 . ASN B 1 101 ? 29.555 -16.481 14.567  1.00 27.25 ? 354 ASN B OD1 1 
ATOM   1763 N ND2 . ASN B 1 101 ? 30.575 -14.638 13.853  1.00 26.69 ? 354 ASN B ND2 1 
ATOM   1764 N N   . LYS B 1 102 ? 26.066 -13.731 17.317  1.00 17.34 ? 355 LYS B N   1 
ATOM   1765 C CA  . LYS B 1 102 ? 25.433 -13.256 18.541  1.00 18.04 ? 355 LYS B CA  1 
ATOM   1766 C C   . LYS B 1 102 ? 24.740 -14.394 19.284  1.00 16.39 ? 355 LYS B C   1 
ATOM   1767 O O   . LYS B 1 102 ? 24.643 -14.385 20.509  1.00 18.19 ? 355 LYS B O   1 
ATOM   1768 C CB  . LYS B 1 102 ? 24.372 -12.208 18.202  1.00 21.20 ? 355 LYS B CB  1 
ATOM   1769 C CG  . LYS B 1 102 ? 23.672 -11.494 19.333  1.00 25.32 ? 355 LYS B CG  1 
ATOM   1770 C CD  . LYS B 1 102 ? 22.652 -10.543 18.745  1.00 26.32 ? 355 LYS B CD  1 
ATOM   1771 C CE  . LYS B 1 102 ? 22.154 -9.506  19.718  1.00 28.93 ? 355 LYS B CE  1 
ATOM   1772 N NZ  . LYS B 1 102 ? 21.311 -8.517  19.011  1.00 30.25 ? 355 LYS B NZ  1 
ATOM   1773 N N   . HIS B 1 103 ? 24.253 -15.388 18.538  1.00 14.00 ? 356 HIS B N   1 
ATOM   1774 C CA  . HIS B 1 103 ? 23.476 -16.480 19.111  1.00 13.10 ? 356 HIS B CA  1 
ATOM   1775 C C   . HIS B 1 103 ? 24.288 -17.757 19.303  1.00 12.83 ? 356 HIS B C   1 
ATOM   1776 O O   . HIS B 1 103 ? 23.941 -18.571 20.149  1.00 14.06 ? 356 HIS B O   1 
ATOM   1777 C CB  . HIS B 1 103 ? 22.257 -16.733 18.231  1.00 12.92 ? 356 HIS B CB  1 
ATOM   1778 C CG  . HIS B 1 103 ? 21.332 -15.594 18.274  1.00 12.82 ? 356 HIS B CG  1 
ATOM   1779 N ND1 . HIS B 1 103 ? 20.578 -15.309 19.393  1.00 13.25 ? 356 HIS B ND1 1 
ATOM   1780 C CD2 . HIS B 1 103 ? 21.047 -14.680 17.354  1.00 13.59 ? 356 HIS B CD2 1 
ATOM   1781 C CE1 . HIS B 1 103 ? 19.877 -14.217 19.135  1.00 13.31 ? 356 HIS B CE1 1 
ATOM   1782 N NE2 . HIS B 1 103 ? 20.141 -13.816 17.897  1.00 14.14 ? 356 HIS B NE2 1 
ATOM   1783 N N   . ILE B 1 104 ? 25.375 -17.941 18.556  1.00 12.84 ? 357 ILE B N   1 
ATOM   1784 C CA  . ILE B 1 104 ? 26.136 -19.167 18.668  1.00 12.68 ? 357 ILE B CA  1 
ATOM   1785 C C   . ILE B 1 104 ? 26.852 -19.176 20.015  1.00 13.88 ? 357 ILE B C   1 
ATOM   1786 O O   . ILE B 1 104 ? 27.666 -18.308 20.287  1.00 14.79 ? 357 ILE B O   1 
ATOM   1787 C CB  . ILE B 1 104 ? 27.131 -19.319 17.506  1.00 13.47 ? 357 ILE B CB  1 
ATOM   1788 C CG1 . ILE B 1 104 ? 26.374 -19.552 16.203  1.00 13.01 ? 357 ILE B CG1 1 
ATOM   1789 C CG2 . ILE B 1 104 ? 28.135 -20.415 17.774  1.00 14.40 ? 357 ILE B CG2 1 
ATOM   1790 C CD1 . ILE B 1 104 ? 27.214 -19.313 14.962  1.00 13.44 ? 357 ILE B CD1 1 
ATOM   1791 N N   . ASP B 1 105 ? 26.567 -20.187 20.845  1.00 13.34 ? 358 ASP B N   1 
ATOM   1792 C CA  . ASP B 1 105 ? 27.204 -20.366 22.142  1.00 14.60 ? 358 ASP B CA  1 
ATOM   1793 C C   . ASP B 1 105 ? 26.947 -19.194 23.089  1.00 14.27 ? 358 ASP B C   1 
ATOM   1794 O O   . ASP B 1 105 ? 27.673 -19.026 24.066  1.00 14.43 ? 358 ASP B O   1 
ATOM   1795 C CB  . ASP B 1 105 ? 28.712 -20.604 22.007  1.00 15.97 ? 358 ASP B CB  1 
ATOM   1796 C CG  . ASP B 1 105 ? 29.066 -21.977 21.459  1.00 17.71 ? 358 ASP B CG  1 
ATOM   1797 O OD1 . ASP B 1 105 ? 28.190 -22.878 21.451  1.00 15.85 ? 358 ASP B OD1 1 
ATOM   1798 O OD2 . ASP B 1 105 ? 30.221 -22.132 21.024  1.00 19.99 ? 358 ASP B OD2 1 
ATOM   1799 N N   . ALA B 1 106 ? 25.879 -18.442 22.872  1.00 13.52 ? 359 ALA B N   1 
ATOM   1800 C CA  . ALA B 1 106 ? 25.570 -17.330 23.759  1.00 13.85 ? 359 ALA B CA  1 
ATOM   1801 C C   . ALA B 1 106 ? 25.286 -17.809 25.182  1.00 13.50 ? 359 ALA B C   1 
ATOM   1802 O O   . ALA B 1 106 ? 25.562 -17.081 26.139  1.00 15.48 ? 359 ALA B O   1 
ATOM   1803 C CB  . ALA B 1 106 ? 24.432 -16.552 23.203  1.00 13.80 ? 359 ALA B CB  1 
ATOM   1804 N N   . TYR B 1 107 ? 24.782 -19.037 25.321  1.00 13.58 ? 360 TYR B N   1 
ATOM   1805 C CA  . TYR B 1 107 ? 24.424 -19.588 26.627  1.00 13.69 ? 360 TYR B CA  1 
ATOM   1806 C C   . TYR B 1 107 ? 25.609 -19.598 27.589  1.00 15.28 ? 360 TYR B C   1 
ATOM   1807 O O   . TYR B 1 107 ? 25.393 -19.655 28.802  1.00 15.15 ? 360 TYR B O   1 
ATOM   1808 C CB  . TYR B 1 107 ? 23.857 -21.010 26.484  1.00 13.40 ? 360 TYR B CB  1 
ATOM   1809 C CG  . TYR B 1 107 ? 24.935 -22.024 26.231  1.00 13.98 ? 360 TYR B CG  1 
ATOM   1810 C CD1 . TYR B 1 107 ? 25.608 -22.618 27.293  1.00 14.54 ? 360 TYR B CD1 1 
ATOM   1811 C CD2 . TYR B 1 107 ? 25.375 -22.303 24.943  1.00 14.07 ? 360 TYR B CD2 1 
ATOM   1812 C CE1 . TYR B 1 107 ? 26.686 -23.454 27.086  1.00 15.60 ? 360 TYR B CE1 1 
ATOM   1813 C CE2 . TYR B 1 107 ? 26.454 -23.137 24.723  1.00 14.62 ? 360 TYR B CE2 1 
ATOM   1814 C CZ  . TYR B 1 107 ? 27.107 -23.717 25.797  1.00 15.90 ? 360 TYR B CZ  1 
ATOM   1815 O OH  . TYR B 1 107 ? 28.175 -24.548 25.612  1.00 17.45 ? 360 TYR B OH  1 
ATOM   1816 N N   . LYS B 1 108 ? 26.845 -19.575 27.077  1.00 15.94 ? 361 LYS B N   1 
ATOM   1817 C CA  . LYS B 1 108 ? 28.024 -19.612 27.934  1.00 15.78 ? 361 LYS B CA  1 
ATOM   1818 C C   . LYS B 1 108 ? 28.082 -18.406 28.868  1.00 17.39 ? 361 LYS B C   1 
ATOM   1819 O O   . LYS B 1 108 ? 28.747 -18.495 29.905  1.00 18.57 ? 361 LYS B O   1 
ATOM   1820 C CB  . LYS B 1 108 ? 29.298 -19.647 27.089  1.00 16.95 ? 361 LYS B CB  1 
ATOM   1821 C CG  . LYS B 1 108 ? 29.507 -20.939 26.330  1.00 18.34 ? 361 LYS B CG  1 
ATOM   1822 C CD  . LYS B 1 108 ? 30.824 -21.005 25.601  1.00 21.74 ? 361 LYS B CD  1 
ATOM   1823 C CE  . LYS B 1 108 ? 31.031 -22.301 24.849  1.00 23.84 ? 361 LYS B CE  1 
ATOM   1824 N NZ  . LYS B 1 108 ? 32.370 -22.324 24.208  1.00 27.77 ? 361 LYS B NZ  1 
ATOM   1825 N N   . THR B 1 109 ? 27.380 -17.314 28.531  1.00 17.62 ? 362 THR B N   1 
ATOM   1826 C CA  . THR B 1 109 ? 27.516 -16.055 29.252  1.00 18.74 ? 362 THR B CA  1 
ATOM   1827 C C   . THR B 1 109 ? 26.458 -15.867 30.341  1.00 18.33 ? 362 THR B C   1 
ATOM   1828 O O   . THR B 1 109 ? 26.488 -14.878 31.051  1.00 19.38 ? 362 THR B O   1 
ATOM   1829 C CB  . THR B 1 109 ? 27.476 -14.864 28.285  1.00 19.79 ? 362 THR B CB  1 
ATOM   1830 O OG1 . THR B 1 109 ? 26.166 -14.726 27.733  1.00 21.75 ? 362 THR B OG1 1 
ATOM   1831 C CG2 . THR B 1 109 ? 28.476 -14.989 27.158  1.00 22.62 ? 362 THR B CG2 1 
ATOM   1832 N N   . PHE B 1 110 ? 25.531 -16.808 30.493  1.00 15.74 ? 363 PHE B N   1 
ATOM   1833 C CA  . PHE B 1 110 ? 24.474 -16.639 31.467  1.00 15.43 ? 363 PHE B CA  1 
ATOM   1834 C C   . PHE B 1 110 ? 24.127 -17.986 32.075  1.00 15.33 ? 363 PHE B C   1 
ATOM   1835 O O   . PHE B 1 110 ? 24.411 -19.016 31.478  1.00 16.23 ? 363 PHE B O   1 
ATOM   1836 C CB  . PHE B 1 110 ? 23.257 -15.975 30.822  1.00 16.94 ? 363 PHE B CB  1 
ATOM   1837 C CG  . PHE B 1 110 ? 22.737 -16.604 29.553  1.00 17.12 ? 363 PHE B CG  1 
ATOM   1838 C CD1 . PHE B 1 110 ? 23.063 -16.057 28.330  1.00 18.27 ? 363 PHE B CD1 1 
ATOM   1839 C CD2 . PHE B 1 110 ? 21.885 -17.693 29.579  1.00 19.64 ? 363 PHE B CD2 1 
ATOM   1840 C CE1 . PHE B 1 110 ? 22.546 -16.573 27.151  1.00 19.92 ? 363 PHE B CE1 1 
ATOM   1841 C CE2 . PHE B 1 110 ? 21.412 -18.245 28.395  1.00 19.56 ? 363 PHE B CE2 1 
ATOM   1842 C CZ  . PHE B 1 110 ? 21.725 -17.666 27.189  1.00 19.31 ? 363 PHE B CZ  1 
ATOM   1843 N N   . PRO B 1 111 ? 23.519 -18.035 33.273  1.00 16.05 ? 364 PRO B N   1 
ATOM   1844 C CA  . PRO B 1 111 ? 23.049 -19.304 33.826  1.00 16.19 ? 364 PRO B CA  1 
ATOM   1845 C C   . PRO B 1 111 ? 22.054 -20.017 32.898  1.00 18.12 ? 364 PRO B C   1 
ATOM   1846 O O   . PRO B 1 111 ? 21.089 -19.380 32.496  1.00 20.92 ? 364 PRO B O   1 
ATOM   1847 C CB  . PRO B 1 111 ? 22.406 -18.919 35.161  1.00 17.75 ? 364 PRO B CB  1 
ATOM   1848 C CG  . PRO B 1 111 ? 23.061 -17.596 35.517  1.00 17.71 ? 364 PRO B CG  1 
ATOM   1849 C CD  . PRO B 1 111 ? 23.270 -16.903 34.185  1.00 17.62 ? 364 PRO B CD  1 
ATOM   1850 O OXT . PRO B 1 111 ? 22.320 -21.178 32.632  1.00 18.64 ? 364 PRO B OXT 1 
ATOM   1851 N N   . LYS C 1 3   ? 40.392 -20.064 8.529   1.00 42.83 ? 256 LYS C N   1 
ATOM   1852 C CA  . LYS C 1 3   ? 40.705 -19.295 9.763   1.00 41.80 ? 256 LYS C CA  1 
ATOM   1853 C C   . LYS C 1 3   ? 40.967 -20.239 10.940  1.00 35.98 ? 256 LYS C C   1 
ATOM   1854 O O   . LYS C 1 3   ? 41.859 -19.921 11.712  1.00 36.14 ? 256 LYS C O   1 
ATOM   1855 C CB  . LYS C 1 3   ? 39.649 -18.215 10.047  1.00 42.60 ? 256 LYS C CB  1 
ATOM   1856 C CG  . LYS C 1 3   ? 39.825 -17.444 11.351  1.00 45.13 ? 256 LYS C CG  1 
ATOM   1857 C CD  . LYS C 1 3   ? 39.652 -15.935 11.212  1.00 46.35 ? 256 LYS C CD  1 
ATOM   1858 C CE  . LYS C 1 3   ? 38.269 -15.521 10.757  1.00 46.63 ? 256 LYS C CE  1 
ATOM   1859 N NZ  . LYS C 1 3   ? 38.303 -14.294 9.926   1.00 47.21 ? 256 LYS C NZ  1 
ATOM   1860 N N   . LYS C 1 4   ? 40.258 -21.376 11.101  1.00 31.25 ? 257 LYS C N   1 
ATOM   1861 C CA  . LYS C 1 4   ? 40.683 -22.297 12.151  1.00 29.54 ? 257 LYS C CA  1 
ATOM   1862 C C   . LYS C 1 4   ? 41.924 -23.072 11.697  1.00 25.53 ? 257 LYS C C   1 
ATOM   1863 O O   . LYS C 1 4   ? 41.900 -23.817 10.725  1.00 24.23 ? 257 LYS C O   1 
ATOM   1864 C CB  . LYS C 1 4   ? 39.616 -23.273 12.642  1.00 31.45 ? 257 LYS C CB  1 
ATOM   1865 C CG  . LYS C 1 4   ? 40.087 -24.109 13.829  1.00 33.67 ? 257 LYS C CG  1 
ATOM   1866 C CD  . LYS C 1 4   ? 39.002 -24.730 14.686  1.00 37.52 ? 257 LYS C CD  1 
ATOM   1867 C CE  . LYS C 1 4   ? 38.533 -23.814 15.798  1.00 40.19 ? 257 LYS C CE  1 
ATOM   1868 N NZ  . LYS C 1 4   ? 37.364 -24.385 16.504  1.00 40.96 ? 257 LYS C NZ  1 
ATOM   1869 N N   . PRO C 1 5   ? 43.075 -22.862 12.372  1.00 22.74 ? 258 PRO C N   1 
ATOM   1870 C CA  . PRO C 1 5   ? 44.292 -23.535 11.965  1.00 19.99 ? 258 PRO C CA  1 
ATOM   1871 C C   . PRO C 1 5   ? 44.128 -25.045 12.120  1.00 17.04 ? 258 PRO C C   1 
ATOM   1872 O O   . PRO C 1 5   ? 43.488 -25.516 13.060  1.00 18.30 ? 258 PRO C O   1 
ATOM   1873 C CB  . PRO C 1 5   ? 45.331 -22.973 12.941  1.00 20.49 ? 258 PRO C CB  1 
ATOM   1874 C CG  . PRO C 1 5   ? 44.763 -21.692 13.466  1.00 23.54 ? 258 PRO C CG  1 
ATOM   1875 C CD  . PRO C 1 5   ? 43.275 -21.944 13.508  1.00 23.75 ? 258 PRO C CD  1 
ATOM   1876 N N   A ARG C 1 6   ? 44.742 -25.782 11.202  0.50 17.61 ? 259 ARG C N   1 
ATOM   1877 N N   B ARG C 1 6   ? 44.738 -25.791 11.199  0.50 17.61 ? 259 ARG C N   1 
ATOM   1878 C CA  A ARG C 1 6   ? 44.646 -27.231 11.178  0.50 17.63 ? 259 ARG C CA  1 
ATOM   1879 C CA  B ARG C 1 6   ? 44.641 -27.242 11.171  0.50 17.60 ? 259 ARG C CA  1 
ATOM   1880 C C   A ARG C 1 6   ? 44.938 -27.831 12.546  0.50 16.47 ? 259 ARG C C   1 
ATOM   1881 C C   B ARG C 1 6   ? 44.938 -27.835 12.544  0.50 16.50 ? 259 ARG C C   1 
ATOM   1882 O O   A ARG C 1 6   ? 44.236 -28.737 12.989  0.50 16.77 ? 259 ARG C O   1 
ATOM   1883 O O   B ARG C 1 6   ? 44.234 -28.741 12.988  0.50 16.76 ? 259 ARG C O   1 
ATOM   1884 C CB  A ARG C 1 6   ? 45.579 -27.853 10.142  0.50 18.90 ? 259 ARG C CB  1 
ATOM   1885 C CB  B ARG C 1 6   ? 45.588 -27.814 10.115  0.50 18.75 ? 259 ARG C CB  1 
ATOM   1886 C CG  A ARG C 1 6   ? 45.367 -29.354 9.991   0.50 21.01 ? 259 ARG C CG  1 
ATOM   1887 C CG  B ARG C 1 6   ? 45.426 -29.303 9.847   0.50 20.66 ? 259 ARG C CG  1 
ATOM   1888 C CD  A ARG C 1 6   ? 46.067 -30.011 8.826   0.50 22.69 ? 259 ARG C CD  1 
ATOM   1889 C CD  B ARG C 1 6   ? 46.200 -29.715 8.604   0.50 22.34 ? 259 ARG C CD  1 
ATOM   1890 N NE  A ARG C 1 6   ? 45.907 -29.238 7.606   0.50 24.18 ? 259 ARG C NE  1 
ATOM   1891 N NE  B ARG C 1 6   ? 46.219 -31.152 8.374   0.50 23.56 ? 259 ARG C NE  1 
ATOM   1892 C CZ  A ARG C 1 6   ? 45.111 -29.579 6.601   0.50 25.27 ? 259 ARG C CZ  1 
ATOM   1893 C CZ  B ARG C 1 6   ? 47.316 -31.898 8.323   0.50 22.54 ? 259 ARG C CZ  1 
ATOM   1894 N NH1 A ARG C 1 6   ? 45.160 -28.903 5.466   0.50 26.73 ? 259 ARG C NH1 1 
ATOM   1895 N NH1 B ARG C 1 6   ? 48.502 -31.314 8.323   0.50 25.52 ? 259 ARG C NH1 1 
ATOM   1896 N NH2 A ARG C 1 6   ? 44.297 -30.614 6.719   0.50 25.31 ? 259 ARG C NH2 1 
ATOM   1897 N NH2 B ARG C 1 6   ? 47.224 -33.217 8.280   0.50 19.88 ? 259 ARG C NH2 1 
ATOM   1898 N N   . GLN C 1 7   ? 45.977 -27.336 13.224  1.00 15.82 ? 260 GLN C N   1 
ATOM   1899 C CA  . GLN C 1 7   ? 46.413 -27.944 14.471  1.00 15.29 ? 260 GLN C CA  1 
ATOM   1900 C C   . GLN C 1 7   ? 45.403 -27.768 15.599  1.00 14.97 ? 260 GLN C C   1 
ATOM   1901 O O   . GLN C 1 7   ? 45.513 -28.447 16.617  1.00 14.20 ? 260 GLN C O   1 
ATOM   1902 C CB  . GLN C 1 7   ? 47.790 -27.428 14.880  1.00 15.26 ? 260 GLN C CB  1 
ATOM   1903 C CG  . GLN C 1 7   ? 47.835 -25.972 15.292  1.00 15.10 ? 260 GLN C CG  1 
ATOM   1904 C CD  . GLN C 1 7   ? 48.067 -25.005 14.155  1.00 15.07 ? 260 GLN C CD  1 
ATOM   1905 O OE1 . GLN C 1 7   ? 47.863 -25.325 12.984  1.00 14.92 ? 260 GLN C OE1 1 
ATOM   1906 N NE2 . GLN C 1 7   ? 48.450 -23.783 14.489  1.00 16.29 ? 260 GLN C NE2 1 
ATOM   1907 N N   . LYS C 1 8   ? 44.415 -26.873 15.439  1.00 15.29 ? 261 LYS C N   1 
ATOM   1908 C CA  . LYS C 1 8   ? 43.416 -26.675 16.472  1.00 15.98 ? 261 LYS C CA  1 
ATOM   1909 C C   . LYS C 1 8   ? 42.092 -27.361 16.142  1.00 16.55 ? 261 LYS C C   1 
ATOM   1910 O O   . LYS C 1 8   ? 41.177 -27.315 16.962  1.00 18.08 ? 261 LYS C O   1 
ATOM   1911 C CB  . LYS C 1 8   ? 43.161 -25.184 16.675  1.00 17.18 ? 261 LYS C CB  1 
ATOM   1912 C CG  . LYS C 1 8   ? 44.349 -24.419 17.239  1.00 17.40 ? 261 LYS C CG  1 
ATOM   1913 C CD  . LYS C 1 8   ? 44.912 -25.035 18.508  1.00 17.41 ? 261 LYS C CD  1 
ATOM   1914 C CE  . LYS C 1 8   ? 45.961 -24.138 19.130  1.00 17.24 ? 261 LYS C CE  1 
ATOM   1915 N NZ  . LYS C 1 8   ? 46.523 -24.751 20.338  1.00 18.29 ? 261 LYS C NZ  1 
ATOM   1916 N N   . ARG C 1 9   ? 42.014 -28.041 15.001  1.00 16.16 ? 262 ARG C N   1 
ATOM   1917 C CA  . ARG C 1 9   ? 40.779 -28.718 14.628  1.00 16.53 ? 262 ARG C CA  1 
ATOM   1918 C C   . ARG C 1 9   ? 40.529 -29.917 15.525  1.00 16.15 ? 262 ARG C C   1 
ATOM   1919 O O   . ARG C 1 9   ? 41.459 -30.532 16.045  1.00 16.12 ? 262 ARG C O   1 
ATOM   1920 C CB  . ARG C 1 9   ? 40.856 -29.161 13.174  1.00 17.33 ? 262 ARG C CB  1 
ATOM   1921 C CG  . ARG C 1 9   ? 40.892 -27.990 12.204  1.00 18.67 ? 262 ARG C CG  1 
ATOM   1922 C CD  . ARG C 1 9   ? 41.160 -28.465 10.796  1.00 19.99 ? 262 ARG C CD  1 
ATOM   1923 N NE  . ARG C 1 9   ? 41.350 -27.325 9.914   1.00 23.27 ? 262 ARG C NE  1 
ATOM   1924 C CZ  . ARG C 1 9   ? 41.695 -27.409 8.638   1.00 27.28 ? 262 ARG C CZ  1 
ATOM   1925 N NH1 . ARG C 1 9   ? 41.791 -26.310 7.913   1.00 30.94 ? 262 ARG C NH1 1 
ATOM   1926 N NH2 . ARG C 1 9   ? 41.940 -28.576 8.073   1.00 27.30 ? 262 ARG C NH2 1 
ATOM   1927 N N   . THR C 1 10  ? 39.254 -30.265 15.666  1.00 17.03 ? 263 THR C N   1 
ATOM   1928 C CA  . THR C 1 10  ? 38.820 -31.441 16.399  1.00 17.70 ? 263 THR C CA  1 
ATOM   1929 C C   . THR C 1 10  ? 37.955 -32.275 15.466  1.00 17.96 ? 263 THR C C   1 
ATOM   1930 O O   . THR C 1 10  ? 36.904 -31.804 15.034  1.00 18.73 ? 263 THR C O   1 
ATOM   1931 C CB  . THR C 1 10  ? 38.002 -31.056 17.640  1.00 21.08 ? 263 THR C CB  1 
ATOM   1932 O OG1 . THR C 1 10  ? 38.776 -30.166 18.442  1.00 25.91 ? 263 THR C OG1 1 
ATOM   1933 C CG2 . THR C 1 10  ? 37.586 -32.250 18.475  1.00 21.12 ? 263 THR C CG2 1 
ATOM   1934 N N   . ALA C 1 11  ? 38.365 -33.506 15.187  1.00 15.58 ? 264 ALA C N   1 
ATOM   1935 C CA  . ALA C 1 11  ? 37.565 -34.371 14.348  1.00 15.47 ? 264 ALA C CA  1 
ATOM   1936 C C   . ALA C 1 11  ? 36.438 -34.977 15.173  1.00 14.99 ? 264 ALA C C   1 
ATOM   1937 O O   . ALA C 1 11  ? 36.610 -35.319 16.331  1.00 15.83 ? 264 ALA C O   1 
ATOM   1938 C CB  . ALA C 1 11  ? 38.402 -35.434 13.715  1.00 15.80 ? 264 ALA C CB  1 
ATOM   1939 N N   . THR C 1 12  ? 35.269 -35.094 14.518  1.00 16.16 ? 265 THR C N   1 
ATOM   1940 C CA  . THR C 1 12  ? 34.081 -35.739 15.057  1.00 17.63 ? 265 THR C CA  1 
ATOM   1941 C C   . THR C 1 12  ? 33.374 -36.422 13.894  1.00 16.73 ? 265 THR C C   1 
ATOM   1942 O O   . THR C 1 12  ? 33.803 -36.316 12.756  1.00 16.03 ? 265 THR C O   1 
ATOM   1943 C CB  . THR C 1 12  ? 33.135 -34.703 15.672  1.00 18.73 ? 265 THR C CB  1 
ATOM   1944 O OG1 . THR C 1 12  ? 32.705 -33.856 14.595  1.00 18.48 ? 265 THR C OG1 1 
ATOM   1945 C CG2 . THR C 1 12  ? 33.779 -33.837 16.734  1.00 20.33 ? 265 THR C CG2 1 
ATOM   1946 N N   . LYS C 1 13  ? 32.216 -37.039 14.165  1.00 17.67 ? 266 LYS C N   1 
ATOM   1947 C CA  . LYS C 1 13  ? 31.433 -37.616 13.091  1.00 18.67 ? 266 LYS C CA  1 
ATOM   1948 C C   . LYS C 1 13  ? 31.025 -36.554 12.073  1.00 18.38 ? 266 LYS C C   1 
ATOM   1949 O O   . LYS C 1 13  ? 30.993 -36.838 10.880  1.00 19.92 ? 266 LYS C O   1 
ATOM   1950 C CB  . LYS C 1 13  ? 30.200 -38.336 13.640  1.00 21.34 ? 266 LYS C CB  1 
ATOM   1951 C CG  . LYS C 1 13  ? 30.501 -39.626 14.376  1.00 23.76 ? 266 LYS C CG  1 
ATOM   1952 C CD  . LYS C 1 13  ? 29.279 -40.264 14.986  1.00 27.90 ? 266 LYS C CD  1 
ATOM   1953 C CE  . LYS C 1 13  ? 29.608 -41.467 15.840  1.00 30.41 ? 266 LYS C CE  1 
ATOM   1954 N NZ  . LYS C 1 13  ? 28.454 -41.862 16.684  1.00 32.95 ? 266 LYS C NZ  1 
ATOM   1955 N N   . ALA C 1 14  ? 30.775 -35.325 12.543  1.00 19.45 ? 267 ALA C N   1 
ATOM   1956 C CA  . ALA C 1 14  ? 30.354 -34.237 11.672  1.00 19.63 ? 267 ALA C CA  1 
ATOM   1957 C C   . ALA C 1 14  ? 31.504 -33.670 10.835  1.00 20.41 ? 267 ALA C C   1 
ATOM   1958 O O   . ALA C 1 14  ? 31.289 -33.049 9.801   1.00 20.75 ? 267 ALA C O   1 
ATOM   1959 C CB  . ALA C 1 14  ? 29.724 -33.163 12.522  1.00 20.17 ? 267 ALA C CB  1 
ATOM   1960 N N   . TYR C 1 15  ? 32.736 -33.852 11.314  1.00 18.77 ? 268 TYR C N   1 
ATOM   1961 C CA  . TYR C 1 15  ? 33.908 -33.276 10.692  1.00 19.44 ? 268 TYR C CA  1 
ATOM   1962 C C   . TYR C 1 15  ? 35.049 -34.257 10.915  1.00 17.51 ? 268 TYR C C   1 
ATOM   1963 O O   . TYR C 1 15  ? 35.737 -34.145 11.914  1.00 18.95 ? 268 TYR C O   1 
ATOM   1964 C CB  . TYR C 1 15  ? 34.207 -31.897 11.278  1.00 20.63 ? 268 TYR C CB  1 
ATOM   1965 C CG  . TYR C 1 15  ? 35.339 -31.130 10.642  1.00 21.20 ? 268 TYR C CG  1 
ATOM   1966 C CD1 . TYR C 1 15  ? 35.446 -30.961 9.264   1.00 21.68 ? 268 TYR C CD1 1 
ATOM   1967 C CD2 . TYR C 1 15  ? 36.330 -30.573 11.432  1.00 21.77 ? 268 TYR C CD2 1 
ATOM   1968 C CE1 . TYR C 1 15  ? 36.481 -30.233 8.700   1.00 21.26 ? 268 TYR C CE1 1 
ATOM   1969 C CE2 . TYR C 1 15  ? 37.361 -29.832 10.883  1.00 20.88 ? 268 TYR C CE2 1 
ATOM   1970 C CZ  . TYR C 1 15  ? 37.429 -29.647 9.516   1.00 21.61 ? 268 TYR C CZ  1 
ATOM   1971 O OH  . TYR C 1 15  ? 38.438 -28.917 8.951   1.00 22.54 ? 268 TYR C OH  1 
ATOM   1972 N N   . ASN C 1 16  ? 35.202 -35.216 10.000  1.00 16.91 ? 269 ASN C N   1 
ATOM   1973 C CA  . ASN C 1 16  ? 35.928 -36.422 10.341  1.00 17.14 ? 269 ASN C CA  1 
ATOM   1974 C C   . ASN C 1 16  ? 37.436 -36.232 10.116  1.00 16.27 ? 269 ASN C C   1 
ATOM   1975 O O   . ASN C 1 16  ? 37.906 -35.172 9.740   1.00 16.29 ? 269 ASN C O   1 
ATOM   1976 C CB  . ASN C 1 16  ? 35.308 -37.627 9.643   1.00 19.70 ? 269 ASN C CB  1 
ATOM   1977 C CG  . ASN C 1 16  ? 35.544 -37.649 8.157   1.00 20.38 ? 269 ASN C CG  1 
ATOM   1978 O OD1 . ASN C 1 16  ? 36.575 -37.194 7.681   1.00 20.53 ? 269 ASN C OD1 1 
ATOM   1979 N ND2 . ASN C 1 16  ? 34.577 -38.157 7.402   1.00 22.42 ? 269 ASN C ND2 1 
ATOM   1980 N N   . VAL C 1 17  ? 38.196 -37.290 10.396  1.00 15.93 ? 270 VAL C N   1 
ATOM   1981 C CA  . VAL C 1 17  ? 39.651 -37.195 10.377  1.00 15.98 ? 270 VAL C CA  1 
ATOM   1982 C C   . VAL C 1 17  ? 40.142 -36.879 8.976   1.00 16.24 ? 270 VAL C C   1 
ATOM   1983 O O   . VAL C 1 17  ? 41.073 -36.092 8.829   1.00 16.59 ? 270 VAL C O   1 
ATOM   1984 C CB  . VAL C 1 17  ? 40.293 -38.481 10.929  1.00 14.20 ? 270 VAL C CB  1 
ATOM   1985 C CG1 . VAL C 1 17  ? 41.811 -38.530 10.703  1.00 14.81 ? 270 VAL C CG1 1 
ATOM   1986 C CG2 . VAL C 1 17  ? 39.955 -38.656 12.394  1.00 14.29 ? 270 VAL C CG2 1 
ATOM   1987 N N   . THR C 1 18  ? 39.519 -37.478 7.958   1.00 17.57 ? 271 THR C N   1 
ATOM   1988 C CA  . THR C 1 18  ? 39.911 -37.197 6.583   1.00 18.90 ? 271 THR C CA  1 
ATOM   1989 C C   . THR C 1 18  ? 39.633 -35.734 6.249   1.00 18.09 ? 271 THR C C   1 
ATOM   1990 O O   . THR C 1 18  ? 40.480 -35.063 5.656   1.00 19.32 ? 271 THR C O   1 
ATOM   1991 C CB  . THR C 1 18  ? 39.138 -38.080 5.596   1.00 21.19 ? 271 THR C CB  1 
ATOM   1992 O OG1 . THR C 1 18  ? 39.343 -39.439 5.956   1.00 26.02 ? 271 THR C OG1 1 
ATOM   1993 C CG2 . THR C 1 18  ? 39.582 -37.868 4.169   1.00 23.49 ? 271 THR C CG2 1 
ATOM   1994 N N   . GLN C 1 19  ? 38.461 -35.239 6.651   1.00 18.35 ? 272 GLN C N   1 
ATOM   1995 C CA  . GLN C 1 19  ? 38.059 -33.884 6.321   1.00 18.93 ? 272 GLN C CA  1 
ATOM   1996 C C   . GLN C 1 19  ? 38.976 -32.892 7.034   1.00 18.44 ? 272 GLN C C   1 
ATOM   1997 O O   . GLN C 1 19  ? 39.365 -31.876 6.473   1.00 21.06 ? 272 GLN C O   1 
ATOM   1998 C CB  . GLN C 1 19  ? 36.593 -33.672 6.702   1.00 19.80 ? 272 GLN C CB  1 
ATOM   1999 C CG  . GLN C 1 19  ? 35.619 -34.486 5.860   1.00 21.36 ? 272 GLN C CG  1 
ATOM   2000 C CD  . GLN C 1 19  ? 34.205 -34.510 6.397   1.00 23.84 ? 272 GLN C CD  1 
ATOM   2001 O OE1 . GLN C 1 19  ? 33.929 -34.479 7.599   1.00 26.74 ? 272 GLN C OE1 1 
ATOM   2002 N NE2 . GLN C 1 19  ? 33.262 -34.731 5.494   1.00 26.00 ? 272 GLN C NE2 1 
ATOM   2003 N N   . ALA C 1 20  ? 39.312 -33.173 8.297   1.00 18.00 ? 273 ALA C N   1 
ATOM   2004 C CA  . ALA C 1 20  ? 40.087 -32.245 9.100   1.00 16.94 ? 273 ALA C CA  1 
ATOM   2005 C C   . ALA C 1 20  ? 41.587 -32.338 8.802   1.00 16.06 ? 273 ALA C C   1 
ATOM   2006 O O   . ALA C 1 20  ? 42.257 -31.308 8.837   1.00 17.55 ? 273 ALA C O   1 
ATOM   2007 C CB  . ALA C 1 20  ? 39.821 -32.509 10.556  1.00 16.65 ? 273 ALA C CB  1 
ATOM   2008 N N   . PHE C 1 21  ? 42.101 -33.545 8.567   1.00 16.48 ? 274 PHE C N   1 
ATOM   2009 C CA  . PHE C 1 21  ? 43.541 -33.788 8.612   1.00 15.83 ? 274 PHE C CA  1 
ATOM   2010 C C   . PHE C 1 21  ? 44.056 -34.540 7.388   1.00 19.16 ? 274 PHE C C   1 
ATOM   2011 O O   . PHE C 1 21  ? 45.233 -34.897 7.338   1.00 19.92 ? 274 PHE C O   1 
ATOM   2012 C CB  . PHE C 1 21  ? 43.912 -34.572 9.875   1.00 15.52 ? 274 PHE C CB  1 
ATOM   2013 C CG  . PHE C 1 21  ? 43.437 -33.915 11.141  1.00 14.87 ? 274 PHE C CG  1 
ATOM   2014 C CD1 . PHE C 1 21  ? 42.580 -34.568 12.003  1.00 14.34 ? 274 PHE C CD1 1 
ATOM   2015 C CD2 . PHE C 1 21  ? 43.807 -32.607 11.452  1.00 14.66 ? 274 PHE C CD2 1 
ATOM   2016 C CE1 . PHE C 1 21  ? 42.122 -33.961 13.157  1.00 14.45 ? 274 PHE C CE1 1 
ATOM   2017 C CE2 . PHE C 1 21  ? 43.325 -31.987 12.588  1.00 14.68 ? 274 PHE C CE2 1 
ATOM   2018 C CZ  . PHE C 1 21  ? 42.493 -32.669 13.443  1.00 14.77 ? 274 PHE C CZ  1 
ATOM   2019 N N   . GLY C 1 22  ? 43.188 -34.814 6.406   1.00 17.96 ? 275 GLY C N   1 
ATOM   2020 C CA  . GLY C 1 22  ? 43.628 -35.443 5.173   1.00 19.79 ? 275 GLY C CA  1 
ATOM   2021 C C   . GLY C 1 22  ? 43.611 -36.968 5.237   1.00 21.18 ? 275 GLY C C   1 
ATOM   2022 O O   . GLY C 1 22  ? 43.578 -37.560 6.310   1.00 19.83 ? 275 GLY C O   1 
ATOM   2023 N N   . ARG C 1 23  ? 43.654 -37.607 4.065   1.00 21.06 ? 276 ARG C N   1 
ATOM   2024 C CA  . ARG C 1 23  ? 43.755 -39.048 3.978   1.00 20.48 ? 276 ARG C CA  1 
ATOM   2025 C C   . ARG C 1 23  ? 45.026 -39.531 4.677   1.00 18.07 ? 276 ARG C C   1 
ATOM   2026 O O   . ARG C 1 23  ? 46.057 -38.881 4.646   1.00 20.43 ? 276 ARG C O   1 
ATOM   2027 C CB  . ARG C 1 23  ? 43.747 -39.493 2.517   1.00 24.25 ? 276 ARG C CB  1 
ATOM   2028 C CG  . ARG C 1 23  ? 42.347 -39.783 2.012   1.00 29.44 ? 276 ARG C CG  1 
ATOM   2029 C CD  . ARG C 1 23  ? 42.331 -40.431 0.646   1.00 33.37 ? 276 ARG C CD  1 
ATOM   2030 N NE  . ARG C 1 23  ? 43.119 -41.660 0.562   1.00 34.35 ? 276 ARG C NE  1 
ATOM   2031 C CZ  . ARG C 1 23  ? 42.646 -42.895 0.713   1.00 36.51 ? 276 ARG C CZ  1 
ATOM   2032 N NH1 . ARG C 1 23  ? 43.384 -43.926 0.336   1.00 37.35 ? 276 ARG C NH1 1 
ATOM   2033 N NH2 . ARG C 1 23  ? 41.421 -43.103 1.170   1.00 38.52 ? 276 ARG C NH2 1 
ATOM   2034 N N   . ARG C 1 24  ? 44.909 -40.687 5.310   1.00 18.49 ? 277 ARG C N   1 
ATOM   2035 C CA  . ARG C 1 24  ? 46.056 -41.356 5.892   1.00 18.63 ? 277 ARG C CA  1 
ATOM   2036 C C   . ARG C 1 24  ? 46.993 -41.816 4.782   1.00 22.23 ? 277 ARG C C   1 
ATOM   2037 O O   . ARG C 1 24  ? 46.554 -42.190 3.700   1.00 23.09 ? 277 ARG C O   1 
ATOM   2038 C CB  . ARG C 1 24  ? 45.604 -42.552 6.720   1.00 17.46 ? 277 ARG C CB  1 
ATOM   2039 C CG  . ARG C 1 24  ? 45.362 -42.233 8.191   1.00 18.29 ? 277 ARG C CG  1 
ATOM   2040 C CD  . ARG C 1 24  ? 44.126 -41.448 8.482   1.00 16.43 ? 277 ARG C CD  1 
ATOM   2041 N NE  . ARG C 1 24  ? 44.266 -40.027 8.261   1.00 14.74 ? 277 ARG C NE  1 
ATOM   2042 C CZ  . ARG C 1 24  ? 44.930 -39.202 9.052   1.00 14.23 ? 277 ARG C CZ  1 
ATOM   2043 N NH1 . ARG C 1 24  ? 45.056 -37.935 8.720   1.00 14.81 ? 277 ARG C NH1 1 
ATOM   2044 N NH2 . ARG C 1 24  ? 45.508 -39.638 10.160  1.00 13.80 ? 277 ARG C NH2 1 
ATOM   2045 N N   . GLY C 1 25  ? 48.293 -41.812 5.064   1.00 22.76 ? 278 GLY C N   1 
ATOM   2046 C CA  . GLY C 1 25  ? 49.235 -42.368 4.111   1.00 24.55 ? 278 GLY C CA  1 
ATOM   2047 C C   . GLY C 1 25  ? 50.651 -42.430 4.663   1.00 26.67 ? 278 GLY C C   1 
ATOM   2048 O O   . GLY C 1 25  ? 50.895 -42.074 5.818   1.00 24.71 ? 278 GLY C O   1 
ATOM   2049 N N   . PRO C 1 26  ? 51.597 -42.910 3.823   1.00 27.32 ? 279 PRO C N   1 
ATOM   2050 C CA  . PRO C 1 26  ? 52.987 -43.113 4.217   1.00 29.46 ? 279 PRO C CA  1 
ATOM   2051 C C   . PRO C 1 26  ? 53.914 -41.917 4.089   1.00 31.37 ? 279 PRO C C   1 
ATOM   2052 O O   . PRO C 1 26  ? 55.030 -41.984 4.598   1.00 36.56 ? 279 PRO C O   1 
ATOM   2053 C CB  . PRO C 1 26  ? 53.453 -44.192 3.230   1.00 27.95 ? 279 PRO C CB  1 
ATOM   2054 C CG  . PRO C 1 26  ? 52.682 -43.888 1.974   1.00 28.70 ? 279 PRO C CG  1 
ATOM   2055 C CD  . PRO C 1 26  ? 51.338 -43.385 2.456   1.00 27.84 ? 279 PRO C CD  1 
ATOM   2056 N N   . GLU C 1 27  ? 53.459 -40.826 3.460   1.00 33.60 ? 280 GLU C N   1 
ATOM   2057 C CA  . GLU C 1 27  ? 54.314 -39.662 3.260   1.00 37.88 ? 280 GLU C CA  1 
ATOM   2058 C C   . GLU C 1 27  ? 54.604 -38.962 4.588   1.00 38.62 ? 280 GLU C C   1 
ATOM   2059 O O   . GLU C 1 27  ? 53.816 -39.037 5.530   1.00 33.05 ? 280 GLU C O   1 
ATOM   2060 C CB  . GLU C 1 27  ? 53.703 -38.642 2.291   1.00 41.00 ? 280 GLU C CB  1 
ATOM   2061 C CG  . GLU C 1 27  ? 53.960 -38.902 0.819   1.00 44.82 ? 280 GLU C CG  1 
ATOM   2062 C CD  . GLU C 1 27  ? 53.505 -37.741 -0.048  1.00 46.92 ? 280 GLU C CD  1 
ATOM   2063 O OE1 . GLU C 1 27  ? 52.568 -37.920 -0.826  1.00 46.91 ? 280 GLU C OE1 1 
ATOM   2064 O OE2 . GLU C 1 27  ? 54.077 -36.647 0.086   1.00 52.61 ? 280 GLU C OE2 1 
ATOM   2065 N N   . GLN C 1 28  ? 55.722 -38.228 4.609   1.00 41.30 ? 281 GLN C N   1 
ATOM   2066 C CA  . GLN C 1 28  ? 56.196 -37.604 5.829   1.00 43.22 ? 281 GLN C CA  1 
ATOM   2067 C C   . GLN C 1 28  ? 55.265 -36.453 6.195   1.00 39.85 ? 281 GLN C C   1 
ATOM   2068 O O   . GLN C 1 28  ? 55.210 -36.050 7.351   1.00 37.09 ? 281 GLN C O   1 
ATOM   2069 C CB  . GLN C 1 28  ? 57.659 -37.177 5.669   1.00 47.57 ? 281 GLN C CB  1 
ATOM   2070 C CG  . GLN C 1 28  ? 58.592 -38.349 5.380   1.00 51.68 ? 281 GLN C CG  1 
ATOM   2071 C CD  . GLN C 1 28  ? 58.436 -39.481 6.371   1.00 55.51 ? 281 GLN C CD  1 
ATOM   2072 O OE1 . GLN C 1 28  ? 58.818 -39.364 7.534   1.00 58.61 ? 281 GLN C OE1 1 
ATOM   2073 N NE2 . GLN C 1 28  ? 57.870 -40.594 5.924   1.00 57.70 ? 281 GLN C NE2 1 
ATOM   2074 N N   . THR C 1 29  ? 54.468 -35.981 5.238   1.00 36.29 ? 282 THR C N   1 
ATOM   2075 C CA  . THR C 1 29  ? 53.554 -34.883 5.469   1.00 31.99 ? 282 THR C CA  1 
ATOM   2076 C C   . THR C 1 29  ? 52.142 -35.375 5.811   1.00 27.13 ? 282 THR C C   1 
ATOM   2077 O O   . THR C 1 29  ? 51.281 -34.558 6.058   1.00 25.85 ? 282 THR C O   1 
ATOM   2078 C CB  . THR C 1 29  ? 53.515 -33.987 4.222   1.00 35.26 ? 282 THR C CB  1 
ATOM   2079 O OG1 . THR C 1 29  ? 53.141 -34.778 3.091   1.00 38.04 ? 282 THR C OG1 1 
ATOM   2080 C CG2 . THR C 1 29  ? 54.836 -33.317 3.904   1.00 36.22 ? 282 THR C CG2 1 
ATOM   2081 N N   . GLN C 1 30  ? 51.927 -36.692 5.763   1.00 25.73 ? 283 GLN C N   1 
ATOM   2082 C CA  . GLN C 1 30  ? 50.613 -37.268 5.970   1.00 22.39 ? 283 GLN C CA  1 
ATOM   2083 C C   . GLN C 1 30  ? 50.540 -37.847 7.380   1.00 19.58 ? 283 GLN C C   1 
ATOM   2084 O O   . GLN C 1 30  ? 51.536 -38.301 7.919   1.00 20.01 ? 283 GLN C O   1 
ATOM   2085 C CB  . GLN C 1 30  ? 50.355 -38.373 4.950   1.00 25.12 ? 283 GLN C CB  1 
ATOM   2086 C CG  . GLN C 1 30  ? 50.238 -37.884 3.511   1.00 27.79 ? 283 GLN C CG  1 
ATOM   2087 C CD  . GLN C 1 30  ? 49.995 -39.073 2.622   1.00 31.27 ? 283 GLN C CD  1 
ATOM   2088 O OE1 . GLN C 1 30  ? 50.801 -39.991 2.577   1.00 28.99 ? 283 GLN C OE1 1 
ATOM   2089 N NE2 . GLN C 1 30  ? 48.825 -39.130 2.001   1.00 33.19 ? 283 GLN C NE2 1 
ATOM   2090 N N   . GLY C 1 31  ? 49.349 -37.861 7.973   1.00 16.50 ? 284 GLY C N   1 
ATOM   2091 C CA  . GLY C 1 31  ? 49.112 -38.691 9.141   1.00 15.22 ? 284 GLY C CA  1 
ATOM   2092 C C   . GLY C 1 31  ? 48.973 -40.160 8.763   1.00 15.24 ? 284 GLY C C   1 
ATOM   2093 O O   . GLY C 1 31  ? 48.486 -40.481 7.685   1.00 16.27 ? 284 GLY C O   1 
ATOM   2094 N N   . ASN C 1 32  ? 49.366 -41.068 9.655   1.00 13.37 ? 285 ASN C N   1 
ATOM   2095 C CA  . ASN C 1 32  ? 49.255 -42.493 9.381   1.00 13.40 ? 285 ASN C CA  1 
ATOM   2096 C C   . ASN C 1 32  ? 48.323 -43.216 10.358  1.00 12.40 ? 285 ASN C C   1 
ATOM   2097 O O   . ASN C 1 32  ? 48.219 -44.433 10.299  1.00 13.65 ? 285 ASN C O   1 
ATOM   2098 C CB  . ASN C 1 32  ? 50.616 -43.190 9.424   1.00 13.45 ? 285 ASN C CB  1 
ATOM   2099 C CG  . ASN C 1 32  ? 51.179 -43.240 10.821  1.00 13.67 ? 285 ASN C CG  1 
ATOM   2100 O OD1 . ASN C 1 32  ? 50.872 -42.386 11.642  1.00 13.73 ? 285 ASN C OD1 1 
ATOM   2101 N ND2 . ASN C 1 32  ? 51.971 -44.262 11.103  1.00 15.62 ? 285 ASN C ND2 1 
ATOM   2102 N N   . PHE C 1 33  ? 47.648 -42.485 11.246  1.00 12.35 ? 286 PHE C N   1 
ATOM   2103 C CA  . PHE C 1 33  ? 46.951 -43.088 12.358  1.00 11.81 ? 286 PHE C CA  1 
ATOM   2104 C C   . PHE C 1 33  ? 45.444 -43.091 12.127  1.00 11.79 ? 286 PHE C C   1 
ATOM   2105 O O   . PHE C 1 33  ? 44.838 -42.041 11.876  1.00 13.03 ? 286 PHE C O   1 
ATOM   2106 C CB  . PHE C 1 33  ? 47.290 -42.341 13.644  1.00 11.97 ? 286 PHE C CB  1 
ATOM   2107 C CG  . PHE C 1 33  ? 46.802 -42.999 14.912  1.00 11.81 ? 286 PHE C CG  1 
ATOM   2108 C CD1 . PHE C 1 33  ? 45.556 -42.703 15.439  1.00 11.78 ? 286 PHE C CD1 1 
ATOM   2109 C CD2 . PHE C 1 33  ? 47.595 -43.906 15.596  1.00 12.09 ? 286 PHE C CD2 1 
ATOM   2110 C CE1 . PHE C 1 33  ? 45.125 -43.307 16.604  1.00 12.48 ? 286 PHE C CE1 1 
ATOM   2111 C CE2 . PHE C 1 33  ? 47.168 -44.476 16.772  1.00 12.14 ? 286 PHE C CE2 1 
ATOM   2112 C CZ  . PHE C 1 33  ? 45.934 -44.176 17.278  1.00 12.38 ? 286 PHE C CZ  1 
ATOM   2113 N N   . GLY C 1 34  ? 44.863 -44.274 12.323  1.00 12.90 ? 287 GLY C N   1 
ATOM   2114 C CA  . GLY C 1 34  ? 43.424 -44.432 12.416  1.00 13.20 ? 287 GLY C CA  1 
ATOM   2115 C C   . GLY C 1 34  ? 42.909 -45.490 11.453  1.00 13.40 ? 287 GLY C C   1 
ATOM   2116 O O   . GLY C 1 34  ? 43.252 -45.477 10.275  1.00 14.58 ? 287 GLY C O   1 
ATOM   2117 N N   . ASP C 1 35  ? 42.103 -46.407 11.984  1.00 14.44 ? 288 ASP C N   1 
ATOM   2118 C CA  . ASP C 1 35  ? 41.346 -47.326 11.149  1.00 15.00 ? 288 ASP C CA  1 
ATOM   2119 C C   . ASP C 1 35  ? 40.097 -46.607 10.641  1.00 17.07 ? 288 ASP C C   1 
ATOM   2120 O O   . ASP C 1 35  ? 39.877 -45.428 10.888  1.00 16.32 ? 288 ASP C O   1 
ATOM   2121 C CB  . ASP C 1 35  ? 41.051 -48.630 11.892  1.00 15.83 ? 288 ASP C CB  1 
ATOM   2122 C CG  . ASP C 1 35  ? 39.964 -48.557 12.949  1.00 15.65 ? 288 ASP C CG  1 
ATOM   2123 O OD1 . ASP C 1 35  ? 39.696 -49.598 13.586  1.00 19.39 ? 288 ASP C OD1 1 
ATOM   2124 O OD2 . ASP C 1 35  ? 39.384 -47.482 13.132  1.00 16.90 ? 288 ASP C OD2 1 
ATOM   2125 N N   . GLN C 1 36  ? 39.264 -47.323 9.877   1.00 17.48 ? 289 GLN C N   1 
ATOM   2126 C CA  . GLN C 1 36  ? 38.150 -46.672 9.212   1.00 18.04 ? 289 GLN C CA  1 
ATOM   2127 C C   . GLN C 1 36  ? 37.168 -46.115 10.235  1.00 16.14 ? 289 GLN C C   1 
ATOM   2128 O O   . GLN C 1 36  ? 36.579 -45.071 10.016  1.00 17.40 ? 289 GLN C O   1 
ATOM   2129 C CB  . GLN C 1 36  ? 37.479 -47.654 8.262   1.00 19.83 ? 289 GLN C CB  1 
ATOM   2130 C CG  . GLN C 1 36  ? 38.341 -47.938 7.045   1.00 22.58 ? 289 GLN C CG  1 
ATOM   2131 C CD  . GLN C 1 36  ? 37.849 -49.074 6.182   1.00 28.68 ? 289 GLN C CD  1 
ATOM   2132 O OE1 . GLN C 1 36  ? 37.469 -48.873 5.030   1.00 34.69 ? 289 GLN C OE1 1 
ATOM   2133 N NE2 . GLN C 1 36  ? 37.867 -50.281 6.729   1.00 31.77 ? 289 GLN C NE2 1 
ATOM   2134 N N   . GLU C 1 37  ? 36.982 -46.792 11.354  1.00 17.06 ? 290 GLU C N   1 
ATOM   2135 C CA  . GLU C 1 37  ? 36.035 -46.358 12.364  1.00 18.68 ? 290 GLU C CA  1 
ATOM   2136 C C   . GLU C 1 37  ? 36.520 -45.067 13.025  1.00 16.64 ? 290 GLU C C   1 
ATOM   2137 O O   . GLU C 1 37  ? 35.776 -44.120 13.179  1.00 17.28 ? 290 GLU C O   1 
ATOM   2138 C CB  . GLU C 1 37  ? 35.814 -47.483 13.372  1.00 22.12 ? 290 GLU C CB  1 
ATOM   2139 C CG  . GLU C 1 37  ? 34.763 -47.183 14.410  1.00 26.07 ? 290 GLU C CG  1 
ATOM   2140 C CD  . GLU C 1 37  ? 34.482 -48.315 15.383  1.00 28.95 ? 290 GLU C CD  1 
ATOM   2141 O OE1 . GLU C 1 37  ? 35.273 -49.285 15.411  1.00 29.68 ? 290 GLU C OE1 1 
ATOM   2142 O OE2 . GLU C 1 37  ? 33.472 -48.226 16.110  1.00 33.25 ? 290 GLU C OE2 1 
ATOM   2143 N N   . LEU C 1 38  ? 37.785 -45.008 13.437  1.00 16.06 ? 291 LEU C N   1 
ATOM   2144 C CA  . LEU C 1 38  ? 38.284 -43.779 14.027  1.00 14.99 ? 291 LEU C CA  1 
ATOM   2145 C C   . LEU C 1 38  ? 38.305 -42.648 13.003  1.00 13.94 ? 291 LEU C C   1 
ATOM   2146 O O   . LEU C 1 38  ? 37.983 -41.511 13.326  1.00 14.37 ? 291 LEU C O   1 
ATOM   2147 C CB  . LEU C 1 38  ? 39.677 -44.022 14.608  1.00 15.73 ? 291 LEU C CB  1 
ATOM   2148 C CG  . LEU C 1 38  ? 40.382 -42.774 15.141  1.00 15.47 ? 291 LEU C CG  1 
ATOM   2149 C CD1 . LEU C 1 38  ? 39.550 -42.019 16.156  1.00 15.85 ? 291 LEU C CD1 1 
ATOM   2150 C CD2 . LEU C 1 38  ? 41.706 -43.158 15.779  1.00 16.14 ? 291 LEU C CD2 1 
ATOM   2151 N N   . ILE C 1 39  ? 38.659 -42.949 11.757  1.00 13.75 ? 292 ILE C N   1 
ATOM   2152 C CA  . ILE C 1 39  ? 38.666 -41.908 10.743  1.00 15.18 ? 292 ILE C CA  1 
ATOM   2153 C C   . ILE C 1 39  ? 37.278 -41.277 10.620  1.00 14.83 ? 292 ILE C C   1 
ATOM   2154 O O   . ILE C 1 39  ? 37.152 -40.067 10.506  1.00 15.86 ? 292 ILE C O   1 
ATOM   2155 C CB  . ILE C 1 39  ? 39.175 -42.465 9.402   1.00 16.08 ? 292 ILE C CB  1 
ATOM   2156 C CG1 . ILE C 1 39  ? 40.678 -42.747 9.477   1.00 16.41 ? 292 ILE C CG1 1 
ATOM   2157 C CG2 . ILE C 1 39  ? 38.835 -41.541 8.259   1.00 17.15 ? 292 ILE C CG2 1 
ATOM   2158 C CD1 . ILE C 1 39  ? 41.192 -43.596 8.348   1.00 17.49 ? 292 ILE C CD1 1 
ATOM   2159 N N   . ARG C 1 40  ? 36.229 -42.103 10.636  1.00 16.31 ? 293 ARG C N   1 
ATOM   2160 C CA  . ARG C 1 40  ? 34.858 -41.652 10.436  1.00 17.91 ? 293 ARG C CA  1 
ATOM   2161 C C   . ARG C 1 40  ? 34.344 -40.916 11.670  1.00 16.89 ? 293 ARG C C   1 
ATOM   2162 O O   . ARG C 1 40  ? 33.530 -40.004 11.551  1.00 18.29 ? 293 ARG C O   1 
ATOM   2163 C CB  . ARG C 1 40  ? 33.999 -42.892 10.148  1.00 21.57 ? 293 ARG C CB  1 
ATOM   2164 C CG  . ARG C 1 40  ? 32.512 -42.651 9.932   1.00 25.78 ? 293 ARG C CG  1 
ATOM   2165 C CD  . ARG C 1 40  ? 31.849 -43.939 9.466   1.00 29.73 ? 293 ARG C CD  1 
ATOM   2166 N NE  . ARG C 1 40  ? 31.792 -44.968 10.502  1.00 33.65 ? 293 ARG C NE  1 
ATOM   2167 C CZ  . ARG C 1 40  ? 32.447 -46.133 10.503  1.00 36.09 ? 293 ARG C CZ  1 
ATOM   2168 N NH1 . ARG C 1 40  ? 32.370 -46.910 11.569  1.00 38.44 ? 293 ARG C NH1 1 
ATOM   2169 N NH2 . ARG C 1 40  ? 33.204 -46.513 9.482   1.00 36.24 ? 293 ARG C NH2 1 
ATOM   2170 N N   . GLN C 1 41  ? 34.848 -41.248 12.864  1.00 16.20 ? 294 GLN C N   1 
ATOM   2171 C CA  . GLN C 1 41  ? 34.224 -40.796 14.098  1.00 16.27 ? 294 GLN C CA  1 
ATOM   2172 C C   . GLN C 1 41  ? 35.053 -39.780 14.877  1.00 15.77 ? 294 GLN C C   1 
ATOM   2173 O O   . GLN C 1 41  ? 34.505 -39.048 15.695  1.00 15.94 ? 294 GLN C O   1 
ATOM   2174 C CB  . GLN C 1 41  ? 33.902 -41.980 15.003  1.00 17.72 ? 294 GLN C CB  1 
ATOM   2175 C CG  . GLN C 1 41  ? 32.898 -42.913 14.358  1.00 19.16 ? 294 GLN C CG  1 
ATOM   2176 C CD  . GLN C 1 41  ? 32.577 -44.111 15.207  1.00 22.87 ? 294 GLN C CD  1 
ATOM   2177 O OE1 . GLN C 1 41  ? 33.228 -44.407 16.205  1.00 22.35 ? 294 GLN C OE1 1 
ATOM   2178 N NE2 . GLN C 1 41  ? 31.577 -44.858 14.777  1.00 27.73 ? 294 GLN C NE2 1 
ATOM   2179 N N   . GLY C 1 42  ? 36.362 -39.720 14.641  1.00 15.87 ? 295 GLY C N   1 
ATOM   2180 C CA  . GLY C 1 42  ? 37.201 -38.784 15.367  1.00 14.67 ? 295 GLY C CA  1 
ATOM   2181 C C   . GLY C 1 42  ? 37.039 -38.966 16.883  1.00 14.65 ? 295 GLY C C   1 
ATOM   2182 O O   . GLY C 1 42  ? 37.026 -40.102 17.393  1.00 15.16 ? 295 GLY C O   1 
ATOM   2183 N N   . THR C 1 43  ? 36.822 -37.848 17.586  1.00 14.12 ? 296 THR C N   1 
ATOM   2184 C CA  . THR C 1 43  ? 36.721 -37.877 19.029  1.00 15.78 ? 296 THR C CA  1 
ATOM   2185 C C   . THR C 1 43  ? 35.425 -38.520 19.522  1.00 15.71 ? 296 THR C C   1 
ATOM   2186 O O   . THR C 1 43  ? 35.301 -38.747 20.727  1.00 17.48 ? 296 THR C O   1 
ATOM   2187 C CB  . THR C 1 43  ? 36.888 -36.475 19.622  1.00 16.90 ? 296 THR C CB  1 
ATOM   2188 O OG1 . THR C 1 43  ? 35.817 -35.653 19.184  1.00 17.16 ? 296 THR C OG1 1 
ATOM   2189 C CG2 . THR C 1 43  ? 38.186 -35.809 19.230  1.00 16.77 ? 296 THR C CG2 1 
ATOM   2190 N N   . ASP C 1 44  ? 34.485 -38.822 18.614  1.00 15.38 ? 297 ASP C N   1 
ATOM   2191 C CA  . ASP C 1 44  ? 33.285 -39.566 18.970  1.00 16.76 ? 297 ASP C CA  1 
ATOM   2192 C C   . ASP C 1 44  ? 33.548 -41.071 19.038  1.00 15.81 ? 297 ASP C C   1 
ATOM   2193 O O   . ASP C 1 44  ? 32.724 -41.836 19.530  1.00 17.24 ? 297 ASP C O   1 
ATOM   2194 C CB  . ASP C 1 44  ? 32.143 -39.276 17.989  1.00 18.15 ? 297 ASP C CB  1 
ATOM   2195 C CG  . ASP C 1 44  ? 31.643 -37.835 17.986  1.00 20.69 ? 297 ASP C CG  1 
ATOM   2196 O OD1 . ASP C 1 44  ? 31.363 -37.301 16.901  1.00 23.65 ? 297 ASP C OD1 1 
ATOM   2197 O OD2 . ASP C 1 44  ? 31.535 -37.267 19.080  1.00 24.94 ? 297 ASP C OD2 1 
ATOM   2198 N N   . TYR C 1 45  ? 34.700 -41.528 18.552  1.00 14.72 ? 298 TYR C N   1 
ATOM   2199 C CA  . TYR C 1 45  ? 35.068 -42.929 18.626  1.00 14.10 ? 298 TYR C CA  1 
ATOM   2200 C C   . TYR C 1 45  ? 35.062 -43.392 20.080  1.00 14.13 ? 298 TYR C C   1 
ATOM   2201 O O   . TYR C 1 45  ? 35.594 -42.717 20.957  1.00 14.74 ? 298 TYR C O   1 
ATOM   2202 C CB  . TYR C 1 45  ? 36.476 -43.057 18.041  1.00 13.93 ? 298 TYR C CB  1 
ATOM   2203 C CG  . TYR C 1 45  ? 37.087 -44.430 17.981  1.00 15.00 ? 298 TYR C CG  1 
ATOM   2204 C CD1 . TYR C 1 45  ? 38.263 -44.702 18.662  1.00 15.53 ? 298 TYR C CD1 1 
ATOM   2205 C CD2 . TYR C 1 45  ? 36.518 -45.456 17.253  1.00 16.66 ? 298 TYR C CD2 1 
ATOM   2206 C CE1 . TYR C 1 45  ? 38.888 -45.926 18.586  1.00 16.03 ? 298 TYR C CE1 1 
ATOM   2207 C CE2 . TYR C 1 45  ? 37.097 -46.716 17.217  1.00 16.95 ? 298 TYR C CE2 1 
ATOM   2208 C CZ  . TYR C 1 45  ? 38.289 -46.945 17.882  1.00 16.69 ? 298 TYR C CZ  1 
ATOM   2209 O OH  . TYR C 1 45  ? 38.927 -48.168 17.810  1.00 17.67 ? 298 TYR C OH  1 
ATOM   2210 N N   . LYS C 1 46  ? 34.488 -44.568 20.338  1.00 15.28 ? 299 LYS C N   1 
ATOM   2211 C CA  . LYS C 1 46  ? 34.240 -45.007 21.695  1.00 16.62 ? 299 LYS C CA  1 
ATOM   2212 C C   . LYS C 1 46  ? 35.527 -45.106 22.515  1.00 16.04 ? 299 LYS C C   1 
ATOM   2213 O O   . LYS C 1 46  ? 35.532 -44.793 23.698  1.00 17.06 ? 299 LYS C O   1 
ATOM   2214 C CB  . LYS C 1 46  ? 33.552 -46.371 21.672  1.00 19.98 ? 299 LYS C CB  1 
ATOM   2215 C CG  . LYS C 1 46  ? 33.430 -47.084 23.012  1.00 23.56 ? 299 LYS C CG  1 
ATOM   2216 C CD  . LYS C 1 46  ? 32.708 -48.434 22.928  1.00 28.15 ? 299 LYS C CD  1 
ATOM   2217 C CE  . LYS C 1 46  ? 33.186 -49.351 21.818  1.00 32.89 ? 299 LYS C CE  1 
ATOM   2218 N NZ  . LYS C 1 46  ? 32.292 -49.326 20.632  1.00 36.18 ? 299 LYS C NZ  1 
ATOM   2219 N N   . HIS C 1 47  ? 36.633 -45.511 21.875  1.00 15.08 ? 300 HIS C N   1 
ATOM   2220 C CA  . HIS C 1 47  ? 37.889 -45.695 22.587  1.00 13.86 ? 300 HIS C CA  1 
ATOM   2221 C C   . HIS C 1 47  ? 38.829 -44.497 22.459  1.00 13.14 ? 300 HIS C C   1 
ATOM   2222 O O   . HIS C 1 47  ? 39.950 -44.575 22.937  1.00 13.93 ? 300 HIS C O   1 
ATOM   2223 C CB  . HIS C 1 47  ? 38.600 -46.944 22.088  1.00 15.21 ? 300 HIS C CB  1 
ATOM   2224 C CG  . HIS C 1 47  ? 37.707 -48.133 22.068  1.00 18.60 ? 300 HIS C CG  1 
ATOM   2225 N ND1 . HIS C 1 47  ? 37.175 -48.645 23.228  1.00 20.52 ? 300 HIS C ND1 1 
ATOM   2226 C CD2 . HIS C 1 47  ? 37.249 -48.873 21.057  1.00 20.65 ? 300 HIS C CD2 1 
ATOM   2227 C CE1 . HIS C 1 47  ? 36.410 -49.690 22.911  1.00 20.76 ? 300 HIS C CE1 1 
ATOM   2228 N NE2 . HIS C 1 47  ? 36.436 -49.844 21.603  1.00 21.65 ? 300 HIS C NE2 1 
ATOM   2229 N N   . TRP C 1 48  ? 38.333 -43.382 21.928  1.00 12.43 ? 301 TRP C N   1 
ATOM   2230 C CA  . TRP C 1 48  ? 39.157 -42.207 21.726  1.00 12.65 ? 301 TRP C CA  1 
ATOM   2231 C C   . TRP C 1 48  ? 39.880 -41.809 23.010  1.00 13.13 ? 301 TRP C C   1 
ATOM   2232 O O   . TRP C 1 48  ? 41.056 -41.462 22.946  1.00 12.54 ? 301 TRP C O   1 
ATOM   2233 C CB  . TRP C 1 48  ? 38.334 -41.056 21.134  1.00 12.24 ? 301 TRP C CB  1 
ATOM   2234 C CG  . TRP C 1 48  ? 39.115 -39.784 21.102  1.00 12.41 ? 301 TRP C CG  1 
ATOM   2235 C CD1 . TRP C 1 48  ? 38.943 -38.710 21.916  1.00 12.70 ? 301 TRP C CD1 1 
ATOM   2236 C CD2 . TRP C 1 48  ? 40.235 -39.485 20.256  1.00 12.85 ? 301 TRP C CD2 1 
ATOM   2237 N NE1 . TRP C 1 48  ? 39.897 -37.766 21.650  1.00 13.44 ? 301 TRP C NE1 1 
ATOM   2238 C CE2 . TRP C 1 48  ? 40.681 -38.202 20.623  1.00 12.79 ? 301 TRP C CE2 1 
ATOM   2239 C CE3 . TRP C 1 48  ? 40.915 -40.175 19.255  1.00 13.11 ? 301 TRP C CE3 1 
ATOM   2240 C CZ2 . TRP C 1 48  ? 41.783 -37.595 20.022  1.00 14.10 ? 301 TRP C CZ2 1 
ATOM   2241 C CZ3 . TRP C 1 48  ? 42.003 -39.580 18.647  1.00 14.67 ? 301 TRP C CZ3 1 
ATOM   2242 C CH2 . TRP C 1 48  ? 42.425 -38.306 19.038  1.00 14.99 ? 301 TRP C CH2 1 
ATOM   2243 N N   . PRO C 1 49  ? 39.246 -41.766 24.202  1.00 12.11 ? 302 PRO C N   1 
ATOM   2244 C CA  . PRO C 1 49  ? 39.957 -41.253 25.369  1.00 12.17 ? 302 PRO C CA  1 
ATOM   2245 C C   . PRO C 1 49  ? 41.218 -42.040 25.692  1.00 11.45 ? 302 PRO C C   1 
ATOM   2246 O O   . PRO C 1 49  ? 42.163 -41.478 26.220  1.00 12.27 ? 302 PRO C O   1 
ATOM   2247 C CB  . PRO C 1 49  ? 38.920 -41.281 26.479  1.00 13.09 ? 302 PRO C CB  1 
ATOM   2248 C CG  . PRO C 1 49  ? 37.603 -41.208 25.726  1.00 12.99 ? 302 PRO C CG  1 
ATOM   2249 C CD  . PRO C 1 49  ? 37.815 -42.004 24.461  1.00 12.62 ? 302 PRO C CD  1 
ATOM   2250 N N   . GLN C 1 50  ? 41.246 -43.340 25.382  1.00 12.32 ? 303 GLN C N   1 
ATOM   2251 C CA  . GLN C 1 50  ? 42.414 -44.168 25.653  1.00 12.74 ? 303 GLN C CA  1 
ATOM   2252 C C   . GLN C 1 50  ? 43.539 -43.901 24.643  1.00 13.07 ? 303 GLN C C   1 
ATOM   2253 O O   . GLN C 1 50  ? 44.660 -44.333 24.855  1.00 13.40 ? 303 GLN C O   1 
ATOM   2254 C CB  . GLN C 1 50  ? 42.035 -45.650 25.695  1.00 12.49 ? 303 GLN C CB  1 
ATOM   2255 C CG  . GLN C 1 50  ? 41.364 -46.069 26.990  1.00 13.22 ? 303 GLN C CG  1 
ATOM   2256 C CD  . GLN C 1 50  ? 42.380 -46.269 28.086  1.00 14.00 ? 303 GLN C CD  1 
ATOM   2257 O OE1 . GLN C 1 50  ? 43.165 -47.215 28.035  1.00 16.28 ? 303 GLN C OE1 1 
ATOM   2258 N NE2 . GLN C 1 50  ? 42.399 -45.390 29.069  1.00 13.68 ? 303 GLN C NE2 1 
ATOM   2259 N N   . ILE C 1 51  ? 43.248 -43.205 23.557  1.00 12.51 ? 304 ILE C N   1 
ATOM   2260 C CA  . ILE C 1 51  ? 44.250 -42.702 22.621  1.00 11.89 ? 304 ILE C CA  1 
ATOM   2261 C C   . ILE C 1 51  ? 44.652 -41.295 23.044  1.00 12.26 ? 304 ILE C C   1 
ATOM   2262 O O   . ILE C 1 51  ? 45.839 -40.987 23.145  1.00 12.34 ? 304 ILE C O   1 
ATOM   2263 C CB  . ILE C 1 51  ? 43.679 -42.738 21.187  1.00 12.66 ? 304 ILE C CB  1 
ATOM   2264 C CG1 . ILE C 1 51  ? 43.399 -44.178 20.768  1.00 13.15 ? 304 ILE C CG1 1 
ATOM   2265 C CG2 . ILE C 1 51  ? 44.603 -42.022 20.222  1.00 13.70 ? 304 ILE C CG2 1 
ATOM   2266 C CD1 . ILE C 1 51  ? 42.504 -44.349 19.590  1.00 13.60 ? 304 ILE C CD1 1 
ATOM   2267 N N   . ALA C 1 52  ? 43.671 -40.432 23.301  1.00 11.50 ? 305 ALA C N   1 
ATOM   2268 C CA  . ALA C 1 52  ? 43.937 -39.031 23.593  1.00 12.39 ? 305 ALA C CA  1 
ATOM   2269 C C   . ALA C 1 52  ? 44.762 -38.859 24.864  1.00 12.63 ? 305 ALA C C   1 
ATOM   2270 O O   . ALA C 1 52  ? 45.431 -37.830 25.012  1.00 12.61 ? 305 ALA C O   1 
ATOM   2271 C CB  . ALA C 1 52  ? 42.648 -38.276 23.710  1.00 12.69 ? 305 ALA C CB  1 
ATOM   2272 N N   . GLN C 1 53  ? 44.755 -39.841 25.767  1.00 11.84 ? 306 GLN C N   1 
ATOM   2273 C CA  . GLN C 1 53  ? 45.558 -39.756 26.979  1.00 12.43 ? 306 GLN C CA  1 
ATOM   2274 C C   . GLN C 1 53  ? 47.041 -39.631 26.643  1.00 13.41 ? 306 GLN C C   1 
ATOM   2275 O O   . GLN C 1 53  ? 47.807 -39.208 27.501  1.00 14.01 ? 306 GLN C O   1 
ATOM   2276 C CB  . GLN C 1 53  ? 45.329 -40.980 27.866  1.00 12.84 ? 306 GLN C CB  1 
ATOM   2277 C CG  . GLN C 1 53  ? 45.962 -42.239 27.304  1.00 13.95 ? 306 GLN C CG  1 
ATOM   2278 C CD  . GLN C 1 53  ? 45.784 -43.431 28.191  1.00 14.49 ? 306 GLN C CD  1 
ATOM   2279 O OE1 . GLN C 1 53  ? 46.069 -43.366 29.386  1.00 17.64 ? 306 GLN C OE1 1 
ATOM   2280 N NE2 . GLN C 1 53  ? 45.368 -44.523 27.601  1.00 14.16 ? 306 GLN C NE2 1 
ATOM   2281 N N   . PHE C 1 54  ? 47.446 -40.002 25.426  1.00 12.23 ? 307 PHE C N   1 
ATOM   2282 C CA  . PHE C 1 54  ? 48.842 -39.909 25.031  1.00 12.49 ? 307 PHE C CA  1 
ATOM   2283 C C   . PHE C 1 54  ? 49.152 -38.607 24.318  1.00 12.84 ? 307 PHE C C   1 
ATOM   2284 O O   . PHE C 1 54  ? 50.329 -38.314 24.130  1.00 13.96 ? 307 PHE C O   1 
ATOM   2285 C CB  . PHE C 1 54  ? 49.277 -41.099 24.184  1.00 12.76 ? 307 PHE C CB  1 
ATOM   2286 C CG  . PHE C 1 54  ? 49.064 -42.401 24.892  1.00 13.21 ? 307 PHE C CG  1 
ATOM   2287 C CD1 . PHE C 1 54  ? 49.710 -42.675 26.086  1.00 14.01 ? 307 PHE C CD1 1 
ATOM   2288 C CD2 . PHE C 1 54  ? 48.149 -43.316 24.408  1.00 13.48 ? 307 PHE C CD2 1 
ATOM   2289 C CE1 . PHE C 1 54  ? 49.434 -43.844 26.775  1.00 14.42 ? 307 PHE C CE1 1 
ATOM   2290 C CE2 . PHE C 1 54  ? 47.925 -44.511 25.071  1.00 14.24 ? 307 PHE C CE2 1 
ATOM   2291 C CZ  . PHE C 1 54  ? 48.580 -44.789 26.242  1.00 14.04 ? 307 PHE C CZ  1 
ATOM   2292 N N   . ALA C 1 55  ? 48.142 -37.833 23.918  1.00 11.63 ? 308 ALA C N   1 
ATOM   2293 C CA  . ALA C 1 55  ? 48.410 -36.582 23.247  1.00 11.73 ? 308 ALA C CA  1 
ATOM   2294 C C   . ALA C 1 55  ? 48.952 -35.576 24.244  1.00 12.56 ? 308 ALA C C   1 
ATOM   2295 O O   . ALA C 1 55  ? 48.483 -35.488 25.375  1.00 13.81 ? 308 ALA C O   1 
ATOM   2296 C CB  . ALA C 1 55  ? 47.174 -36.063 22.592  1.00 11.71 ? 308 ALA C CB  1 
ATOM   2297 N N   . PRO C 1 56  ? 49.949 -34.769 23.842  1.00 12.21 ? 309 PRO C N   1 
ATOM   2298 C CA  . PRO C 1 56  ? 50.544 -33.833 24.788  1.00 12.15 ? 309 PRO C CA  1 
ATOM   2299 C C   . PRO C 1 56  ? 49.747 -32.554 24.992  1.00 12.46 ? 309 PRO C C   1 
ATOM   2300 O O   . PRO C 1 56  ? 49.122 -32.022 24.083  1.00 13.39 ? 309 PRO C O   1 
ATOM   2301 C CB  . PRO C 1 56  ? 51.870 -33.506 24.114  1.00 12.84 ? 309 PRO C CB  1 
ATOM   2302 C CG  . PRO C 1 56  ? 51.569 -33.649 22.635  1.00 12.72 ? 309 PRO C CG  1 
ATOM   2303 C CD  . PRO C 1 56  ? 50.655 -34.847 22.554  1.00 12.64 ? 309 PRO C CD  1 
ATOM   2304 N N   . SER C 1 57  ? 49.790 -32.051 26.224  1.00 12.85 ? 310 SER C N   1 
ATOM   2305 C CA  . SER C 1 57  ? 49.392 -30.690 26.518  1.00 12.50 ? 310 SER C CA  1 
ATOM   2306 C C   . SER C 1 57  ? 50.240 -29.738 25.692  1.00 12.01 ? 310 SER C C   1 
ATOM   2307 O O   . SER C 1 57  ? 51.293 -30.122 25.193  1.00 12.27 ? 310 SER C O   1 
ATOM   2308 C CB  . SER C 1 57  ? 49.564 -30.415 27.974  1.00 13.67 ? 310 SER C CB  1 
ATOM   2309 O OG  . SER C 1 57  ? 50.945 -30.403 28.303  1.00 13.39 ? 310 SER C OG  1 
ATOM   2310 N N   . ALA C 1 58  ? 49.821 -28.484 25.574  1.00 12.56 ? 311 ALA C N   1 
ATOM   2311 C CA  . ALA C 1 58  ? 50.623 -27.531 24.824  1.00 12.43 ? 311 ALA C CA  1 
ATOM   2312 C C   . ALA C 1 58  ? 52.006 -27.390 25.459  1.00 12.07 ? 311 ALA C C   1 
ATOM   2313 O O   . ALA C 1 58  ? 53.018 -27.323 24.770  1.00 12.01 ? 311 ALA C O   1 
ATOM   2314 C CB  . ALA C 1 58  ? 49.939 -26.193 24.750  1.00 13.57 ? 311 ALA C CB  1 
ATOM   2315 N N   . SER C 1 59  ? 52.047 -27.350 26.792  1.00 12.02 ? 312 SER C N   1 
ATOM   2316 C CA  . SER C 1 59  ? 53.292 -27.246 27.526  1.00 12.74 ? 312 SER C CA  1 
ATOM   2317 C C   . SER C 1 59  ? 54.186 -28.439 27.211  1.00 11.82 ? 312 SER C C   1 
ATOM   2318 O O   . SER C 1 59  ? 55.363 -28.287 26.928  1.00 12.49 ? 312 SER C O   1 
ATOM   2319 C CB  . SER C 1 59  ? 52.989 -27.135 28.996  1.00 13.89 ? 312 SER C CB  1 
ATOM   2320 O OG  . SER C 1 59  ? 54.162 -26.888 29.744  1.00 14.05 ? 312 SER C OG  1 
ATOM   2321 N N   . ALA C 1 60  ? 53.619 -29.639 27.265  1.00 12.18 ? 313 ALA C N   1 
ATOM   2322 C CA  . ALA C 1 60  ? 54.390 -30.843 27.024  1.00 11.86 ? 313 ALA C CA  1 
ATOM   2323 C C   . ALA C 1 60  ? 54.789 -30.943 25.555  1.00 11.23 ? 313 ALA C C   1 
ATOM   2324 O O   . ALA C 1 60  ? 55.859 -31.471 25.236  1.00 11.89 ? 313 ALA C O   1 
ATOM   2325 C CB  . ALA C 1 60  ? 53.626 -32.062 27.462  1.00 12.50 ? 313 ALA C CB  1 
ATOM   2326 N N   . PHE C 1 61  ? 53.938 -30.492 24.633  1.00 10.97 ? 314 PHE C N   1 
ATOM   2327 C CA  . PHE C 1 61  ? 54.296 -30.524 23.226  1.00 10.91 ? 314 PHE C CA  1 
ATOM   2328 C C   . PHE C 1 61  ? 55.588 -29.756 23.006  1.00 11.43 ? 314 PHE C C   1 
ATOM   2329 O O   . PHE C 1 61  ? 56.505 -30.235 22.368  1.00 11.50 ? 314 PHE C O   1 
ATOM   2330 C CB  . PHE C 1 61  ? 53.159 -29.940 22.392  1.00 10.83 ? 314 PHE C CB  1 
ATOM   2331 C CG  . PHE C 1 61  ? 53.424 -29.856 20.917  1.00 11.55 ? 314 PHE C CG  1 
ATOM   2332 C CD1 . PHE C 1 61  ? 53.375 -30.986 20.125  1.00 11.86 ? 314 PHE C CD1 1 
ATOM   2333 C CD2 . PHE C 1 61  ? 53.818 -28.665 20.344  1.00 12.81 ? 314 PHE C CD2 1 
ATOM   2334 C CE1 . PHE C 1 61  ? 53.593 -30.896 18.761  1.00 13.05 ? 314 PHE C CE1 1 
ATOM   2335 C CE2 . PHE C 1 61  ? 54.093 -28.590 18.989  1.00 13.09 ? 314 PHE C CE2 1 
ATOM   2336 C CZ  . PHE C 1 61  ? 53.978 -29.712 18.202  1.00 13.85 ? 314 PHE C CZ  1 
ATOM   2337 N N   . PHE C 1 62  ? 55.658 -28.543 23.551  1.00 11.58 ? 315 PHE C N   1 
ATOM   2338 C CA  . PHE C 1 62  ? 56.848 -27.722 23.415  1.00 11.01 ? 315 PHE C CA  1 
ATOM   2339 C C   . PHE C 1 62  ? 57.954 -28.108 24.387  1.00 12.43 ? 315 PHE C C   1 
ATOM   2340 O O   . PHE C 1 62  ? 59.096 -27.723 24.162  1.00 12.18 ? 315 PHE C O   1 
ATOM   2341 C CB  . PHE C 1 62  ? 56.502 -26.238 23.523  1.00 12.18 ? 315 PHE C CB  1 
ATOM   2342 C CG  . PHE C 1 62  ? 55.957 -25.705 22.232  1.00 11.87 ? 315 PHE C CG  1 
ATOM   2343 C CD1 . PHE C 1 62  ? 54.590 -25.517 22.057  1.00 12.45 ? 315 PHE C CD1 1 
ATOM   2344 C CD2 . PHE C 1 62  ? 56.800 -25.474 21.158  1.00 11.88 ? 315 PHE C CD2 1 
ATOM   2345 C CE1 . PHE C 1 62  ? 54.092 -25.065 20.844  1.00 11.96 ? 315 PHE C CE1 1 
ATOM   2346 C CE2 . PHE C 1 62  ? 56.290 -25.036 19.949  1.00 13.05 ? 315 PHE C CE2 1 
ATOM   2347 C CZ  . PHE C 1 62  ? 54.940 -24.793 19.810  1.00 12.56 ? 315 PHE C CZ  1 
ATOM   2348 N N   . GLY C 1 63  ? 57.636 -28.838 25.444  1.00 11.39 ? 316 GLY C N   1 
ATOM   2349 C CA  . GLY C 1 63  ? 58.606 -29.226 26.452  1.00 11.78 ? 316 GLY C CA  1 
ATOM   2350 C C   . GLY C 1 63  ? 59.315 -30.526 26.118  1.00 12.37 ? 316 GLY C C   1 
ATOM   2351 O O   . GLY C 1 63  ? 60.495 -30.670 26.415  1.00 13.03 ? 316 GLY C O   1 
ATOM   2352 N N   . MET C 1 64  ? 58.602 -31.486 25.535  1.00 12.50 ? 317 MET C N   1 
ATOM   2353 C CA  . MET C 1 64  ? 59.141 -32.817 25.306  1.00 12.70 ? 317 MET C CA  1 
ATOM   2354 C C   . MET C 1 64  ? 59.749 -32.938 23.914  1.00 12.32 ? 317 MET C C   1 
ATOM   2355 O O   . MET C 1 64  ? 60.631 -33.764 23.706  1.00 14.74 ? 317 MET C O   1 
ATOM   2356 C CB  . MET C 1 64  ? 58.028 -33.855 25.374  1.00 13.65 ? 317 MET C CB  1 
ATOM   2357 C CG  . MET C 1 64  ? 57.400 -33.966 26.741  1.00 13.61 ? 317 MET C CG  1 
ATOM   2358 S SD  . MET C 1 64  ? 56.158 -35.263 26.829  1.00 16.16 ? 317 MET C SD  1 
ATOM   2359 C CE  . MET C 1 64  ? 55.223 -34.944 25.339  1.00 17.72 ? 317 MET C CE  1 
ATOM   2360 N N   . SER C 1 65  ? 59.208 -32.206 22.933  1.00 11.74 ? 318 SER C N   1 
ATOM   2361 C CA  . SER C 1 65  ? 59.514 -32.448 21.541  1.00 11.09 ? 318 SER C CA  1 
ATOM   2362 C C   . SER C 1 65  ? 60.838 -31.841 21.095  1.00 11.06 ? 318 SER C C   1 
ATOM   2363 O O   . SER C 1 65  ? 61.264 -30.821 21.620  1.00 12.19 ? 318 SER C O   1 
ATOM   2364 C CB  . SER C 1 65  ? 58.431 -31.919 20.644  1.00 11.10 ? 318 SER C CB  1 
ATOM   2365 O OG  . SER C 1 65  ? 57.147 -32.395 21.019  1.00 12.29 ? 318 SER C OG  1 
ATOM   2366 N N   . ARG C 1 66  ? 61.409 -32.417 20.032  1.00 10.98 ? 319 ARG C N   1 
ATOM   2367 C CA  . ARG C 1 66  ? 62.405 -31.703 19.253  1.00 11.24 ? 319 ARG C CA  1 
ATOM   2368 C C   . ARG C 1 66  ? 61.679 -30.865 18.217  1.00 12.27 ? 319 ARG C C   1 
ATOM   2369 O O   . ARG C 1 66  ? 60.952 -31.423 17.396  1.00 12.49 ? 319 ARG C O   1 
ATOM   2370 C CB  . ARG C 1 66  ? 63.394 -32.682 18.628  1.00 13.15 ? 319 ARG C CB  1 
ATOM   2371 C CG  . ARG C 1 66  ? 64.146 -33.485 19.665  1.00 15.20 ? 319 ARG C CG  1 
ATOM   2372 C CD  . ARG C 1 66  ? 65.416 -34.084 19.091  1.00 16.75 ? 319 ARG C CD  1 
ATOM   2373 N NE  . ARG C 1 66  ? 66.348 -33.064 18.650  1.00 16.49 ? 319 ARG C NE  1 
ATOM   2374 C CZ  . ARG C 1 66  ? 67.038 -32.258 19.444  1.00 16.94 ? 319 ARG C CZ  1 
ATOM   2375 N NH1 . ARG C 1 66  ? 67.776 -31.307 18.902  1.00 16.54 ? 319 ARG C NH1 1 
ATOM   2376 N NH2 . ARG C 1 66  ? 66.998 -32.386 20.755  1.00 16.44 ? 319 ARG C NH2 1 
ATOM   2377 N N   . ILE C 1 67  ? 61.842 -29.551 18.329  1.00 11.69 ? 320 ILE C N   1 
ATOM   2378 C CA  . ILE C 1 67  ? 61.162 -28.579 17.492  1.00 12.06 ? 320 ILE C CA  1 
ATOM   2379 C C   . ILE C 1 67  ? 62.145 -28.024 16.475  1.00 12.46 ? 320 ILE C C   1 
ATOM   2380 O O   . ILE C 1 67  ? 63.300 -27.760 16.810  1.00 13.69 ? 320 ILE C O   1 
ATOM   2381 C CB  . ILE C 1 67  ? 60.571 -27.460 18.365  1.00 12.49 ? 320 ILE C CB  1 
ATOM   2382 C CG1 . ILE C 1 67  ? 59.604 -27.991 19.419  1.00 12.30 ? 320 ILE C CG1 1 
ATOM   2383 C CG2 . ILE C 1 67  ? 59.935 -26.391 17.513  1.00 12.60 ? 320 ILE C CG2 1 
ATOM   2384 C CD1 . ILE C 1 67  ? 58.340 -28.633 18.900  1.00 12.88 ? 320 ILE C CD1 1 
ATOM   2385 N N   . GLY C 1 68  ? 61.687 -27.827 15.252  1.00 12.33 ? 321 GLY C N   1 
ATOM   2386 C CA  . GLY C 1 68  ? 62.494 -27.205 14.225  1.00 13.37 ? 321 GLY C CA  1 
ATOM   2387 C C   . GLY C 1 68  ? 61.605 -26.361 13.330  1.00 13.81 ? 321 GLY C C   1 
ATOM   2388 O O   . GLY C 1 68  ? 60.396 -26.305 13.497  1.00 13.29 ? 321 GLY C O   1 
ATOM   2389 N N   A MET C 1 69  ? 62.244 -25.654 12.401  0.70 14.63 ? 322 MET C N   1 
ATOM   2390 N N   B MET C 1 69  ? 62.253 -25.701 12.372  0.30 14.33 ? 322 MET C N   1 
ATOM   2391 C CA  A MET C 1 69  ? 61.548 -24.873 11.401  0.70 16.31 ? 322 MET C CA  1 
ATOM   2392 C CA  B MET C 1 69  ? 61.575 -24.875 11.395  0.30 15.12 ? 322 MET C CA  1 
ATOM   2393 C C   A MET C 1 69  ? 62.155 -25.209 10.046  0.70 16.78 ? 322 MET C C   1 
ATOM   2394 C C   B MET C 1 69  ? 62.165 -25.196 10.033  0.30 15.77 ? 322 MET C C   1 
ATOM   2395 O O   A MET C 1 69  ? 63.380 -25.227 9.920   0.70 20.05 ? 322 MET C O   1 
ATOM   2396 O O   B MET C 1 69  ? 63.388 -25.171 9.887   0.30 17.06 ? 322 MET C O   1 
ATOM   2397 C CB  A MET C 1 69  ? 61.729 -23.385 11.701  0.70 20.25 ? 322 MET C CB  1 
ATOM   2398 C CB  B MET C 1 69  ? 61.803 -23.399 11.710  0.30 16.30 ? 322 MET C CB  1 
ATOM   2399 C CG  A MET C 1 69  ? 60.767 -22.457 10.985  0.70 24.19 ? 322 MET C CG  1 
ATOM   2400 C CG  B MET C 1 69  ? 61.050 -22.965 12.934  0.30 16.95 ? 322 MET C CG  1 
ATOM   2401 S SD  A MET C 1 69  ? 60.047 -21.202 12.111  0.70 29.91 ? 322 MET C SD  1 
ATOM   2402 S SD  B MET C 1 69  ? 59.309 -22.790 12.567  0.30 20.26 ? 322 MET C SD  1 
ATOM   2403 C CE  A MET C 1 69  ? 59.329 -22.270 13.359  0.70 31.71 ? 322 MET C CE  1 
ATOM   2404 C CE  B MET C 1 69  ? 59.332 -21.171 11.803  0.30 21.64 ? 322 MET C CE  1 
ATOM   2405 N N   . GLU C 1 70  ? 61.295 -25.496 9.063   1.00 15.84 ? 323 GLU C N   1 
ATOM   2406 C CA  . GLU C 1 70  ? 61.740 -25.839 7.725   1.00 16.81 ? 323 GLU C CA  1 
ATOM   2407 C C   . GLU C 1 70  ? 60.945 -25.007 6.736   1.00 16.43 ? 323 GLU C C   1 
ATOM   2408 O O   . GLU C 1 70  ? 59.752 -24.787 6.881   1.00 17.53 ? 323 GLU C O   1 
ATOM   2409 C CB  . GLU C 1 70  ? 61.528 -27.319 7.398   1.00 19.02 ? 323 GLU C CB  1 
ATOM   2410 C CG  . GLU C 1 70  ? 62.313 -28.272 8.276   1.00 23.53 ? 323 GLU C CG  1 
ATOM   2411 C CD  . GLU C 1 70  ? 63.825 -28.191 8.191   1.00 27.54 ? 323 GLU C CD  1 
ATOM   2412 O OE1 . GLU C 1 70  ? 64.495 -28.691 9.120   1.00 30.54 ? 323 GLU C OE1 1 
ATOM   2413 O OE2 . GLU C 1 70  ? 64.335 -27.668 7.187   1.00 29.81 ? 323 GLU C OE2 1 
ATOM   2414 N N   . VAL C 1 71  ? 61.627 -24.537 5.696   1.00 16.56 ? 324 VAL C N   1 
ATOM   2415 C CA  . VAL C 1 71  ? 60.973 -23.864 4.594   1.00 17.78 ? 324 VAL C CA  1 
ATOM   2416 C C   . VAL C 1 71  ? 60.972 -24.818 3.415   1.00 17.80 ? 324 VAL C C   1 
ATOM   2417 O O   . VAL C 1 71  ? 62.010 -25.325 2.989   1.00 19.96 ? 324 VAL C O   1 
ATOM   2418 C CB  . VAL C 1 71  ? 61.648 -22.521 4.282   1.00 18.90 ? 324 VAL C CB  1 
ATOM   2419 C CG1 . VAL C 1 71  ? 60.944 -21.817 3.132   1.00 20.39 ? 324 VAL C CG1 1 
ATOM   2420 C CG2 . VAL C 1 71  ? 61.694 -21.637 5.514   1.00 20.08 ? 324 VAL C CG2 1 
ATOM   2421 N N   . THR C 1 72  ? 59.781 -25.078 2.905   1.00 16.48 ? 325 THR C N   1 
ATOM   2422 C CA  . THR C 1 72  ? 59.622 -25.921 1.742   1.00 18.68 ? 325 THR C CA  1 
ATOM   2423 C C   . THR C 1 72  ? 58.875 -25.117 0.696   1.00 18.00 ? 325 THR C C   1 
ATOM   2424 O O   . THR C 1 72  ? 58.434 -24.007 0.962   1.00 16.75 ? 325 THR C O   1 
ATOM   2425 C CB  . THR C 1 72  ? 58.861 -27.191 2.100   1.00 19.69 ? 325 THR C CB  1 
ATOM   2426 O OG1 . THR C 1 72  ? 57.486 -26.834 2.242   1.00 20.55 ? 325 THR C OG1 1 
ATOM   2427 C CG2 . THR C 1 72  ? 59.380 -27.872 3.346   1.00 22.15 ? 325 THR C CG2 1 
ATOM   2428 N N   . PRO C 1 73  ? 58.708 -25.640 -0.532  1.00 19.50 ? 326 PRO C N   1 
ATOM   2429 C CA  . PRO C 1 73  ? 57.939 -24.899 -1.530  1.00 20.21 ? 326 PRO C CA  1 
ATOM   2430 C C   . PRO C 1 73  ? 56.537 -24.497 -1.069  1.00 19.26 ? 326 PRO C C   1 
ATOM   2431 O O   . PRO C 1 73  ? 56.076 -23.430 -1.457  1.00 19.08 ? 326 PRO C O   1 
ATOM   2432 C CB  . PRO C 1 73  ? 57.893 -25.883 -2.706  1.00 22.70 ? 326 PRO C CB  1 
ATOM   2433 C CG  . PRO C 1 73  ? 59.189 -26.645 -2.550  1.00 24.74 ? 326 PRO C CG  1 
ATOM   2434 C CD  . PRO C 1 73  ? 59.295 -26.885 -1.056  1.00 22.41 ? 326 PRO C CD  1 
ATOM   2435 N N   . SER C 1 74  ? 55.912 -25.297 -0.185  1.00 18.01 ? 327 SER C N   1 
ATOM   2436 C CA  . SER C 1 74  ? 54.552 -25.023 0.232   1.00 19.30 ? 327 SER C CA  1 
ATOM   2437 C C   . SER C 1 74  ? 54.466 -24.015 1.374   1.00 18.43 ? 327 SER C C   1 
ATOM   2438 O O   . SER C 1 74  ? 53.395 -23.448 1.591   1.00 20.20 ? 327 SER C O   1 
ATOM   2439 C CB  . SER C 1 74  ? 53.862 -26.282 0.606   1.00 20.71 ? 327 SER C CB  1 
ATOM   2440 O OG  . SER C 1 74  ? 54.445 -26.867 1.764   1.00 22.95 ? 327 SER C OG  1 
ATOM   2441 N N   . GLY C 1 75  ? 55.560 -23.774 2.089   1.00 16.62 ? 328 GLY C N   1 
ATOM   2442 C CA  . GLY C 1 75  ? 55.451 -22.871 3.210   1.00 16.14 ? 328 GLY C CA  1 
ATOM   2443 C C   . GLY C 1 75  ? 56.553 -23.073 4.220   1.00 15.56 ? 328 GLY C C   1 
ATOM   2444 O O   . GLY C 1 75  ? 57.543 -23.735 3.962   1.00 14.73 ? 328 GLY C O   1 
ATOM   2445 N N   . THR C 1 76  ? 56.300 -22.484 5.380   1.00 14.27 ? 329 THR C N   1 
ATOM   2446 C CA  . THR C 1 76  ? 57.191 -22.541 6.517   1.00 14.56 ? 329 THR C CA  1 
ATOM   2447 C C   . THR C 1 76  ? 56.512 -23.408 7.563   1.00 14.10 ? 329 THR C C   1 
ATOM   2448 O O   . THR C 1 76  ? 55.356 -23.172 7.923   1.00 15.06 ? 329 THR C O   1 
ATOM   2449 C CB  . THR C 1 76  ? 57.456 -21.136 7.037   1.00 15.63 ? 329 THR C CB  1 
ATOM   2450 O OG1 . THR C 1 76  ? 58.039 -20.387 5.965   1.00 17.67 ? 329 THR C OG1 1 
ATOM   2451 C CG2 . THR C 1 76  ? 58.390 -21.155 8.217   1.00 15.59 ? 329 THR C CG2 1 
ATOM   2452 N N   . TRP C 1 77  ? 57.250 -24.412 8.027   1.00 13.40 ? 330 TRP C N   1 
ATOM   2453 C CA  . TRP C 1 77  ? 56.692 -25.476 8.846   1.00 13.80 ? 330 TRP C CA  1 
ATOM   2454 C C   . TRP C 1 77  ? 57.427 -25.566 10.172  1.00 14.40 ? 330 TRP C C   1 
ATOM   2455 O O   . TRP C 1 77  ? 58.656 -25.585 10.194  1.00 15.72 ? 330 TRP C O   1 
ATOM   2456 C CB  . TRP C 1 77  ? 56.807 -26.809 8.110   1.00 15.42 ? 330 TRP C CB  1 
ATOM   2457 C CG  . TRP C 1 77  ? 56.024 -26.874 6.841   1.00 16.10 ? 330 TRP C CG  1 
ATOM   2458 C CD1 . TRP C 1 77  ? 56.388 -26.390 5.621   1.00 17.78 ? 330 TRP C CD1 1 
ATOM   2459 C CD2 . TRP C 1 77  ? 54.719 -27.441 6.676   1.00 16.84 ? 330 TRP C CD2 1 
ATOM   2460 N NE1 . TRP C 1 77  ? 55.395 -26.629 4.710   1.00 18.59 ? 330 TRP C NE1 1 
ATOM   2461 C CE2 . TRP C 1 77  ? 54.355 -27.260 5.325   1.00 18.15 ? 330 TRP C CE2 1 
ATOM   2462 C CE3 . TRP C 1 77  ? 53.821 -28.079 7.540   1.00 17.92 ? 330 TRP C CE3 1 
ATOM   2463 C CZ2 . TRP C 1 77  ? 53.144 -27.720 4.820   1.00 20.07 ? 330 TRP C CZ2 1 
ATOM   2464 C CZ3 . TRP C 1 77  ? 52.631 -28.544 7.035   1.00 20.62 ? 330 TRP C CZ3 1 
ATOM   2465 C CH2 . TRP C 1 77  ? 52.295 -28.350 5.696   1.00 20.58 ? 330 TRP C CH2 1 
ATOM   2466 N N   . LEU C 1 78  ? 56.648 -25.695 11.251  1.00 13.18 ? 331 LEU C N   1 
ATOM   2467 C CA  . LEU C 1 78  ? 57.201 -26.026 12.555  1.00 12.91 ? 331 LEU C CA  1 
ATOM   2468 C C   . LEU C 1 78  ? 57.211 -27.537 12.676  1.00 12.84 ? 331 LEU C C   1 
ATOM   2469 O O   . LEU C 1 78  ? 56.156 -28.155 12.690  1.00 14.33 ? 331 LEU C O   1 
ATOM   2470 C CB  . LEU C 1 78  ? 56.326 -25.394 13.630  1.00 13.99 ? 331 LEU C CB  1 
ATOM   2471 C CG  . LEU C 1 78  ? 56.813 -25.518 15.065  1.00 16.63 ? 331 LEU C CG  1 
ATOM   2472 C CD1 . LEU C 1 78  ? 58.046 -24.665 15.281  1.00 19.78 ? 331 LEU C CD1 1 
ATOM   2473 C CD2 . LEU C 1 78  ? 55.709 -25.073 16.007  1.00 18.34 ? 331 LEU C CD2 1 
ATOM   2474 N N   . THR C 1 79  ? 58.400 -28.138 12.711  1.00 12.06 ? 332 THR C N   1 
ATOM   2475 C CA  . THR C 1 79  ? 58.534 -29.575 12.780  1.00 11.55 ? 332 THR C CA  1 
ATOM   2476 C C   . THR C 1 79  ? 58.612 -29.999 14.239  1.00 11.33 ? 332 THR C C   1 
ATOM   2477 O O   . THR C 1 79  ? 59.087 -29.261 15.102  1.00 11.45 ? 332 THR C O   1 
ATOM   2478 C CB  . THR C 1 79  ? 59.759 -30.047 12.003  1.00 12.80 ? 332 THR C CB  1 
ATOM   2479 O OG1 . THR C 1 79  ? 60.902 -29.511 12.659  1.00 13.65 ? 332 THR C OG1 1 
ATOM   2480 C CG2 . THR C 1 79  ? 59.715 -29.610 10.560  1.00 14.01 ? 332 THR C CG2 1 
ATOM   2481 N N   . TYR C 1 80  ? 58.136 -31.219 14.491  1.00 11.44 ? 333 TYR C N   1 
ATOM   2482 C CA  . TYR C 1 80  ? 58.157 -31.734 15.847  1.00 11.17 ? 333 TYR C CA  1 
ATOM   2483 C C   . TYR C 1 80  ? 58.373 -33.235 15.810  1.00 11.60 ? 333 TYR C C   1 
ATOM   2484 O O   . TYR C 1 80  ? 57.858 -33.919 14.944  1.00 12.40 ? 333 TYR C O   1 
ATOM   2485 C CB  . TYR C 1 80  ? 56.880 -31.377 16.598  1.00 11.64 ? 333 TYR C CB  1 
ATOM   2486 C CG  . TYR C 1 80  ? 55.615 -31.922 15.999  1.00 11.42 ? 333 TYR C CG  1 
ATOM   2487 C CD1 . TYR C 1 80  ? 54.900 -31.201 15.060  1.00 11.88 ? 333 TYR C CD1 1 
ATOM   2488 C CD2 . TYR C 1 80  ? 55.122 -33.157 16.362  1.00 11.88 ? 333 TYR C CD2 1 
ATOM   2489 C CE1 . TYR C 1 80  ? 53.728 -31.681 14.514  1.00 11.47 ? 333 TYR C CE1 1 
ATOM   2490 C CE2 . TYR C 1 80  ? 53.942 -33.653 15.828  1.00 11.82 ? 333 TYR C CE2 1 
ATOM   2491 C CZ  . TYR C 1 80  ? 53.255 -32.916 14.890  1.00 12.26 ? 333 TYR C CZ  1 
ATOM   2492 O OH  . TYR C 1 80  ? 52.100 -33.365 14.295  1.00 13.20 ? 333 TYR C OH  1 
ATOM   2493 N N   A THR C 1 81  ? 59.140 -33.744 16.773  0.50 10.99 ? 334 THR C N   1 
ATOM   2494 N N   B THR C 1 81  ? 59.145 -33.735 16.772  0.50 11.17 ? 334 THR C N   1 
ATOM   2495 C CA  A THR C 1 81  ? 59.355 -35.178 16.927  0.50 11.41 ? 334 THR C CA  1 
ATOM   2496 C CA  B THR C 1 81  ? 59.330 -35.169 16.936  0.50 11.94 ? 334 THR C CA  1 
ATOM   2497 C C   A THR C 1 81  ? 59.519 -35.482 18.409  0.50 11.57 ? 334 THR C C   1 
ATOM   2498 C C   B THR C 1 81  ? 59.500 -35.474 18.417  0.50 11.78 ? 334 THR C C   1 
ATOM   2499 O O   A THR C 1 81  ? 60.015 -34.646 19.162  0.50 12.17 ? 334 THR C O   1 
ATOM   2500 O O   B THR C 1 81  ? 59.946 -34.628 19.191  0.50 12.19 ? 334 THR C O   1 
ATOM   2501 C CB  A THR C 1 81  ? 60.589 -35.699 16.170  0.50 12.19 ? 334 THR C CB  1 
ATOM   2502 C CB  B THR C 1 81  ? 60.546 -35.681 16.161  0.50 13.44 ? 334 THR C CB  1 
ATOM   2503 O OG1 A THR C 1 81  ? 61.767 -35.233 16.840  0.50 13.81 ? 334 THR C OG1 1 
ATOM   2504 O OG1 B THR C 1 81  ? 60.472 -37.103 16.097  0.50 14.89 ? 334 THR C OG1 1 
ATOM   2505 C CG2 A THR C 1 81  ? 60.638 -35.293 14.715  0.50 12.17 ? 334 THR C CG2 1 
ATOM   2506 C CG2 B THR C 1 81  ? 61.834 -35.239 16.814  0.50 14.81 ? 334 THR C CG2 1 
ATOM   2507 N N   . GLY C 1 82  ? 59.132 -36.688 18.818  1.00 11.18 ? 335 GLY C N   1 
ATOM   2508 C CA  . GLY C 1 82  ? 59.322 -37.085 20.198  1.00 10.86 ? 335 GLY C CA  1 
ATOM   2509 C C   . GLY C 1 82  ? 58.804 -38.489 20.448  1.00 11.34 ? 335 GLY C C   1 
ATOM   2510 O O   . GLY C 1 82  ? 58.450 -39.207 19.519  1.00 11.25 ? 335 GLY C O   1 
ATOM   2511 N N   . ALA C 1 83  ? 58.789 -38.853 21.717  1.00 11.73 ? 336 ALA C N   1 
ATOM   2512 C CA  . ALA C 1 83  ? 58.335 -40.164 22.133  1.00 12.13 ? 336 ALA C CA  1 
ATOM   2513 C C   . ALA C 1 83  ? 57.709 -40.050 23.511  1.00 12.49 ? 336 ALA C C   1 
ATOM   2514 O O   . ALA C 1 83  ? 58.233 -39.345 24.355  1.00 15.02 ? 336 ALA C O   1 
ATOM   2515 C CB  . ALA C 1 83  ? 59.474 -41.150 22.128  1.00 13.97 ? 336 ALA C CB  1 
ATOM   2516 N N   . ILE C 1 84  ? 56.592 -40.749 23.707  1.00 12.40 ? 337 ILE C N   1 
ATOM   2517 C CA  . ILE C 1 84  ? 55.812 -40.706 24.930  1.00 13.02 ? 337 ILE C CA  1 
ATOM   2518 C C   . ILE C 1 84  ? 55.703 -42.122 25.481  1.00 13.06 ? 337 ILE C C   1 
ATOM   2519 O O   . ILE C 1 84  ? 55.241 -43.027 24.804  1.00 13.45 ? 337 ILE C O   1 
ATOM   2520 C CB  . ILE C 1 84  ? 54.439 -40.085 24.623  1.00 13.45 ? 337 ILE C CB  1 
ATOM   2521 C CG1 . ILE C 1 84  ? 54.623 -38.599 24.314  1.00 14.54 ? 337 ILE C CG1 1 
ATOM   2522 C CG2 . ILE C 1 84  ? 53.482 -40.280 25.792  1.00 13.71 ? 337 ILE C CG2 1 
ATOM   2523 C CD1 . ILE C 1 84  ? 53.493 -37.970 23.554  1.00 15.33 ? 337 ILE C CD1 1 
ATOM   2524 N N   . LYS C 1 85  ? 56.110 -42.304 26.727  1.00 13.17 ? 338 LYS C N   1 
ATOM   2525 C CA  . LYS C 1 85  ? 56.129 -43.635 27.301  1.00 14.15 ? 338 LYS C CA  1 
ATOM   2526 C C   . LYS C 1 85  ? 54.734 -43.995 27.818  1.00 13.59 ? 338 LYS C C   1 
ATOM   2527 O O   . LYS C 1 85  ? 54.120 -43.234 28.544  1.00 14.36 ? 338 LYS C O   1 
ATOM   2528 C CB  . LYS C 1 85  ? 57.160 -43.712 28.427  1.00 15.80 ? 338 LYS C CB  1 
ATOM   2529 C CG  . LYS C 1 85  ? 57.513 -45.134 28.814  1.00 18.07 ? 338 LYS C CG  1 
ATOM   2530 C CD  . LYS C 1 85  ? 58.522 -45.253 29.920  1.00 22.85 ? 338 LYS C CD  1 
ATOM   2531 C CE  . LYS C 1 85  ? 57.928 -44.970 31.278  1.00 26.58 ? 338 LYS C CE  1 
ATOM   2532 N NZ  . LYS C 1 85  ? 58.694 -45.641 32.358  1.00 30.83 ? 338 LYS C NZ  1 
ATOM   2533 N N   . LEU C 1 86  ? 54.275 -45.189 27.465  1.00 13.97 ? 339 LEU C N   1 
ATOM   2534 C CA  . LEU C 1 86  ? 53.077 -45.781 28.031  1.00 14.44 ? 339 LEU C CA  1 
ATOM   2535 C C   . LEU C 1 86  ? 53.373 -46.220 29.462  1.00 14.84 ? 339 LEU C C   1 
ATOM   2536 O O   . LEU C 1 86  ? 54.499 -46.515 29.833  1.00 15.49 ? 339 LEU C O   1 
ATOM   2537 C CB  . LEU C 1 86  ? 52.619 -46.990 27.202  1.00 14.76 ? 339 LEU C CB  1 
ATOM   2538 C CG  . LEU C 1 86  ? 51.721 -46.661 26.012  1.00 15.54 ? 339 LEU C CG  1 
ATOM   2539 C CD1 . LEU C 1 86  ? 52.471 -45.873 24.951  1.00 16.85 ? 339 LEU C CD1 1 
ATOM   2540 C CD2 . LEU C 1 86  ? 51.128 -47.928 25.443  1.00 16.39 ? 339 LEU C CD2 1 
ATOM   2541 N N   . ASP C 1 87  ? 52.323 -46.249 30.270  1.00 16.38 ? 340 ASP C N   1 
ATOM   2542 C CA  . ASP C 1 87  ? 52.439 -46.739 31.634  1.00 18.72 ? 340 ASP C CA  1 
ATOM   2543 C C   . ASP C 1 87  ? 52.112 -48.227 31.638  1.00 19.48 ? 340 ASP C C   1 
ATOM   2544 O O   . ASP C 1 87  ? 50.946 -48.602 31.608  1.00 18.07 ? 340 ASP C O   1 
ATOM   2545 C CB  . ASP C 1 87  ? 51.508 -45.946 32.548  1.00 19.51 ? 340 ASP C CB  1 
ATOM   2546 C CG  . ASP C 1 87  ? 51.606 -46.349 34.009  1.00 21.62 ? 340 ASP C CG  1 
ATOM   2547 O OD1 . ASP C 1 87  ? 50.890 -45.708 34.813  1.00 27.65 ? 340 ASP C OD1 1 
ATOM   2548 O OD2 . ASP C 1 87  ? 52.392 -47.280 34.324  1.00 23.06 ? 340 ASP C OD2 1 
ATOM   2549 N N   A ASP C 1 88  ? 53.144 -49.073 31.693  0.50 19.96 ? 341 ASP C N   1 
ATOM   2550 N N   B ASP C 1 88  ? 53.134 -49.088 31.696  0.50 20.13 ? 341 ASP C N   1 
ATOM   2551 C CA  A ASP C 1 88  ? 52.957 -50.519 31.636  0.50 22.08 ? 341 ASP C CA  1 
ATOM   2552 C CA  B ASP C 1 88  ? 52.878 -50.522 31.603  0.50 22.22 ? 341 ASP C CA  1 
ATOM   2553 C C   A ASP C 1 88  ? 52.301 -51.065 32.902  0.50 21.88 ? 341 ASP C C   1 
ATOM   2554 C C   B ASP C 1 88  ? 52.338 -51.083 32.920  0.50 21.93 ? 341 ASP C C   1 
ATOM   2555 O O   A ASP C 1 88  ? 51.894 -52.223 32.928  0.50 25.65 ? 341 ASP C O   1 
ATOM   2556 O O   B ASP C 1 88  ? 51.971 -52.254 32.965  0.50 26.15 ? 341 ASP C O   1 
ATOM   2557 C CB  A ASP C 1 88  ? 54.266 -51.248 31.330  0.50 24.25 ? 341 ASP C CB  1 
ATOM   2558 C CB  B ASP C 1 88  ? 54.061 -51.295 31.007  0.50 24.24 ? 341 ASP C CB  1 
ATOM   2559 C CG  A ASP C 1 88  ? 55.228 -51.350 32.500  0.50 26.43 ? 341 ASP C CG  1 
ATOM   2560 C CG  B ASP C 1 88  ? 55.285 -51.452 31.890  0.50 27.41 ? 341 ASP C CG  1 
ATOM   2561 O OD1 A ASP C 1 88  ? 55.559 -50.304 33.080  0.50 27.04 ? 341 ASP C OD1 1 
ATOM   2562 O OD1 B ASP C 1 88  ? 55.190 -51.158 33.100  0.50 27.42 ? 341 ASP C OD1 1 
ATOM   2563 O OD2 A ASP C 1 88  ? 55.646 -52.482 32.808  0.50 29.49 ? 341 ASP C OD2 1 
ATOM   2564 O OD2 B ASP C 1 88  ? 56.322 -51.889 31.349  0.50 29.66 ? 341 ASP C OD2 1 
ATOM   2565 N N   . LYS C 1 89  ? 52.198 -50.234 33.945  1.00 21.84 ? 342 LYS C N   1 
ATOM   2566 C CA  . LYS C 1 89  ? 51.536 -50.617 35.192  1.00 24.85 ? 342 LYS C CA  1 
ATOM   2567 C C   . LYS C 1 89  ? 50.041 -50.317 35.153  1.00 23.60 ? 342 LYS C C   1 
ATOM   2568 O O   . LYS C 1 89  ? 49.307 -50.715 36.060  1.00 23.96 ? 342 LYS C O   1 
ATOM   2569 C CB  . LYS C 1 89  ? 52.160 -49.869 36.369  1.00 27.25 ? 342 LYS C CB  1 
ATOM   2570 C CG  . LYS C 1 89  ? 53.637 -50.168 36.596  1.00 32.15 ? 342 LYS C CG  1 
ATOM   2571 C CD  . LYS C 1 89  ? 54.354 -49.187 37.493  1.00 36.77 ? 342 LYS C CD  1 
ATOM   2572 C CE  . LYS C 1 89  ? 54.984 -48.025 36.752  1.00 39.87 ? 342 LYS C CE  1 
ATOM   2573 N NZ  . LYS C 1 89  ? 54.047 -46.889 36.598  1.00 41.13 ? 342 LYS C NZ  1 
ATOM   2574 N N   . ASP C 1 90  ? 49.587 -49.578 34.137  1.00 20.23 ? 343 ASP C N   1 
ATOM   2575 C CA  . ASP C 1 90  ? 48.166 -49.310 33.952  1.00 18.77 ? 343 ASP C CA  1 
ATOM   2576 C C   . ASP C 1 90  ? 47.452 -50.627 33.671  1.00 17.82 ? 343 ASP C C   1 
ATOM   2577 O O   . ASP C 1 90  ? 47.858 -51.372 32.786  1.00 18.19 ? 343 ASP C O   1 
ATOM   2578 C CB  . ASP C 1 90  ? 47.968 -48.283 32.831  1.00 17.44 ? 343 ASP C CB  1 
ATOM   2579 C CG  . ASP C 1 90  ? 46.540 -47.807 32.591  1.00 17.20 ? 343 ASP C CG  1 
ATOM   2580 O OD1 . ASP C 1 90  ? 46.381 -46.813 31.898  1.00 17.46 ? 343 ASP C OD1 1 
ATOM   2581 O OD2 . ASP C 1 90  ? 45.601 -48.465 33.059  1.00 18.30 ? 343 ASP C OD2 1 
ATOM   2582 N N   . PRO C 1 91  ? 46.377 -50.990 34.419  1.00 18.49 ? 344 PRO C N   1 
ATOM   2583 C CA  . PRO C 1 91  ? 45.624 -52.195 34.107  1.00 19.12 ? 344 PRO C CA  1 
ATOM   2584 C C   . PRO C 1 91  ? 45.111 -52.235 32.671  1.00 17.08 ? 344 PRO C C   1 
ATOM   2585 O O   . PRO C 1 91  ? 44.862 -53.304 32.138  1.00 18.72 ? 344 PRO C O   1 
ATOM   2586 C CB  . PRO C 1 91  ? 44.441 -52.175 35.089  1.00 19.97 ? 344 PRO C CB  1 
ATOM   2587 C CG  . PRO C 1 91  ? 44.834 -51.228 36.167  1.00 22.34 ? 344 PRO C CG  1 
ATOM   2588 C CD  . PRO C 1 91  ? 45.864 -50.285 35.599  1.00 20.47 ? 344 PRO C CD  1 
ATOM   2589 N N   . ASN C 1 92  ? 44.962 -51.053 32.046  1.00 16.26 ? 345 ASN C N   1 
ATOM   2590 C CA  . ASN C 1 92  ? 44.503 -50.962 30.669  1.00 15.52 ? 345 ASN C CA  1 
ATOM   2591 C C   . ASN C 1 92  ? 45.638 -51.089 29.647  1.00 14.32 ? 345 ASN C C   1 
ATOM   2592 O O   . ASN C 1 92  ? 45.383 -51.000 28.456  1.00 14.15 ? 345 ASN C O   1 
ATOM   2593 C CB  . ASN C 1 92  ? 43.734 -49.666 30.440  1.00 15.50 ? 345 ASN C CB  1 
ATOM   2594 C CG  . ASN C 1 92  ? 42.423 -49.659 31.190  1.00 16.42 ? 345 ASN C CG  1 
ATOM   2595 O OD1 . ASN C 1 92  ? 41.716 -50.664 31.249  1.00 18.72 ? 345 ASN C OD1 1 
ATOM   2596 N ND2 . ASN C 1 92  ? 42.074 -48.503 31.698  1.00 16.96 ? 345 ASN C ND2 1 
ATOM   2597 N N   . PHE C 1 93  ? 46.874 -51.322 30.101  1.00 14.42 ? 346 PHE C N   1 
ATOM   2598 C CA  . PHE C 1 93  ? 48.029 -51.314 29.205  1.00 14.75 ? 346 PHE C CA  1 
ATOM   2599 C C   . PHE C 1 93  ? 47.865 -52.285 28.045  1.00 14.61 ? 346 PHE C C   1 
ATOM   2600 O O   . PHE C 1 93  ? 48.118 -51.937 26.904  1.00 14.87 ? 346 PHE C O   1 
ATOM   2601 C CB  . PHE C 1 93  ? 49.315 -51.606 29.971  1.00 14.62 ? 346 PHE C CB  1 
ATOM   2602 C CG  . PHE C 1 93  ? 50.515 -51.739 29.075  1.00 15.07 ? 346 PHE C CG  1 
ATOM   2603 C CD1 . PHE C 1 93  ? 50.993 -52.988 28.724  1.00 16.01 ? 346 PHE C CD1 1 
ATOM   2604 C CD2 . PHE C 1 93  ? 51.171 -50.613 28.595  1.00 16.11 ? 346 PHE C CD2 1 
ATOM   2605 C CE1 . PHE C 1 93  ? 52.085 -53.118 27.886  1.00 16.09 ? 346 PHE C CE1 1 
ATOM   2606 C CE2 . PHE C 1 93  ? 52.265 -50.757 27.756  1.00 16.91 ? 346 PHE C CE2 1 
ATOM   2607 C CZ  . PHE C 1 93  ? 52.751 -52.002 27.452  1.00 16.43 ? 346 PHE C CZ  1 
ATOM   2608 N N   . LYS C 1 94  ? 47.495 -53.533 28.307  1.00 15.33 ? 347 LYS C N   1 
ATOM   2609 C CA  . LYS C 1 94  ? 47.443 -54.512 27.234  1.00 16.83 ? 347 LYS C CA  1 
ATOM   2610 C C   . LYS C 1 94  ? 46.421 -54.108 26.177  1.00 15.24 ? 347 LYS C C   1 
ATOM   2611 O O   . LYS C 1 94  ? 46.641 -54.282 24.971  1.00 15.64 ? 347 LYS C O   1 
ATOM   2612 C CB  . LYS C 1 94  ? 47.178 -55.905 27.806  1.00 19.29 ? 347 LYS C CB  1 
ATOM   2613 C CG  . LYS C 1 94  ? 48.368 -56.460 28.574  1.00 23.19 ? 347 LYS C CG  1 
ATOM   2614 C CD  . LYS C 1 94  ? 48.028 -57.723 29.312  1.00 25.00 ? 347 LYS C CD  1 
ATOM   2615 C CE  . LYS C 1 94  ? 49.186 -58.264 30.109  1.00 28.89 ? 347 LYS C CE  1 
ATOM   2616 N NZ  . LYS C 1 94  ? 48.812 -59.568 30.694  1.00 30.32 ? 347 LYS C NZ  1 
ATOM   2617 N N   . ASP C 1 95  ? 45.299 -53.540 26.635  1.00 14.97 ? 348 ASP C N   1 
ATOM   2618 C CA  . ASP C 1 95  ? 44.264 -53.050 25.735  1.00 14.96 ? 348 ASP C CA  1 
ATOM   2619 C C   . ASP C 1 95  ? 44.773 -51.856 24.921  1.00 13.75 ? 348 ASP C C   1 
ATOM   2620 O O   . ASP C 1 95  ? 44.439 -51.722 23.751  1.00 14.54 ? 348 ASP C O   1 
ATOM   2621 C CB  . ASP C 1 95  ? 42.995 -52.681 26.507  1.00 16.47 ? 348 ASP C CB  1 
ATOM   2622 C CG  . ASP C 1 95  ? 42.161 -53.878 26.939  1.00 19.79 ? 348 ASP C CG  1 
ATOM   2623 O OD1 . ASP C 1 95  ? 42.422 -54.985 26.450  1.00 21.39 ? 348 ASP C OD1 1 
ATOM   2624 O OD2 . ASP C 1 95  ? 41.240 -53.677 27.750  1.00 24.79 ? 348 ASP C OD2 1 
ATOM   2625 N N   . GLN C 1 96  ? 45.582 -51.009 25.548  1.00 13.36 ? 349 GLN C N   1 
ATOM   2626 C CA  . GLN C 1 96  ? 46.150 -49.861 24.851  1.00 13.12 ? 349 GLN C CA  1 
ATOM   2627 C C   . GLN C 1 96  ? 47.094 -50.307 23.746  1.00 13.48 ? 349 GLN C C   1 
ATOM   2628 O O   . GLN C 1 96  ? 47.086 -49.736 22.675  1.00 13.22 ? 349 GLN C O   1 
ATOM   2629 C CB  . GLN C 1 96  ? 46.910 -48.975 25.836  1.00 13.35 ? 349 GLN C CB  1 
ATOM   2630 C CG  . GLN C 1 96  ? 45.981 -48.280 26.806  1.00 13.36 ? 349 GLN C CG  1 
ATOM   2631 C CD  . GLN C 1 96  ? 46.694 -47.795 28.039  1.00 14.43 ? 349 GLN C CD  1 
ATOM   2632 O OE1 . GLN C 1 96  ? 47.910 -47.896 28.170  1.00 15.29 ? 349 GLN C OE1 1 
ATOM   2633 N NE2 . GLN C 1 96  ? 45.922 -47.315 29.003  1.00 14.73 ? 349 GLN C NE2 1 
ATOM   2634 N N   . VAL C 1 97  ? 47.913 -51.327 23.998  1.00 13.20 ? 350 VAL C N   1 
ATOM   2635 C CA  . VAL C 1 97  ? 48.809 -51.824 22.971  1.00 13.75 ? 350 VAL C CA  1 
ATOM   2636 C C   . VAL C 1 97  ? 48.005 -52.310 21.772  1.00 13.34 ? 350 VAL C C   1 
ATOM   2637 O O   . VAL C 1 97  ? 48.322 -51.985 20.631  1.00 13.92 ? 350 VAL C O   1 
ATOM   2638 C CB  . VAL C 1 97  ? 49.733 -52.913 23.529  1.00 14.25 ? 350 VAL C CB  1 
ATOM   2639 C CG1 . VAL C 1 97  ? 50.498 -53.654 22.430  1.00 15.72 ? 350 VAL C CG1 1 
ATOM   2640 C CG2 . VAL C 1 97  ? 50.684 -52.338 24.555  1.00 14.50 ? 350 VAL C CG2 1 
ATOM   2641 N N   . ILE C 1 98  ? 46.962 -53.094 22.058  1.00 13.99 ? 351 ILE C N   1 
ATOM   2642 C CA  . ILE C 1 98  ? 46.127 -53.624 20.989  1.00 15.15 ? 351 ILE C CA  1 
ATOM   2643 C C   . ILE C 1 98  ? 45.469 -52.478 20.212  1.00 15.07 ? 351 ILE C C   1 
ATOM   2644 O O   . ILE C 1 98  ? 45.412 -52.479 18.996  1.00 15.84 ? 351 ILE C O   1 
ATOM   2645 C CB  . ILE C 1 98  ? 45.109 -54.626 21.555  1.00 18.04 ? 351 ILE C CB  1 
ATOM   2646 C CG1 . ILE C 1 98  ? 45.801 -55.905 22.033  1.00 20.27 ? 351 ILE C CG1 1 
ATOM   2647 C CG2 . ILE C 1 98  ? 44.033 -54.930 20.520  1.00 18.97 ? 351 ILE C CG2 1 
ATOM   2648 C CD1 . ILE C 1 98  ? 44.970 -56.751 22.968  1.00 23.16 ? 351 ILE C CD1 1 
ATOM   2649 N N   . LEU C 1 99  ? 44.927 -51.510 20.934  1.00 14.55 ? 352 LEU C N   1 
ATOM   2650 C CA  . LEU C 1 99  ? 44.257 -50.375 20.332  1.00 14.23 ? 352 LEU C CA  1 
ATOM   2651 C C   . LEU C 1 99  ? 45.200 -49.570 19.451  1.00 13.76 ? 352 LEU C C   1 
ATOM   2652 O O   . LEU C 1 99  ? 44.865 -49.252 18.338  1.00 15.21 ? 352 LEU C O   1 
ATOM   2653 C CB  . LEU C 1 99  ? 43.678 -49.508 21.460  1.00 14.62 ? 352 LEU C CB  1 
ATOM   2654 C CG  . LEU C 1 99  ? 42.945 -48.252 21.022  1.00 15.62 ? 352 LEU C CG  1 
ATOM   2655 C CD1 . LEU C 1 99  ? 41.716 -48.630 20.228  1.00 16.50 ? 352 LEU C CD1 1 
ATOM   2656 C CD2 . LEU C 1 99  ? 42.552 -47.479 22.267  1.00 15.78 ? 352 LEU C CD2 1 
ATOM   2657 N N   . LEU C 1 100 ? 46.407 -49.278 19.926  1.00 13.24 ? 353 LEU C N   1 
ATOM   2658 C CA  . LEU C 1 100 ? 47.332 -48.496 19.123  1.00 13.90 ? 353 LEU C CA  1 
ATOM   2659 C C   . LEU C 1 100 ? 47.754 -49.297 17.902  1.00 14.53 ? 353 LEU C C   1 
ATOM   2660 O O   . LEU C 1 100 ? 47.785 -48.755 16.817  1.00 15.45 ? 353 LEU C O   1 
ATOM   2661 C CB  . LEU C 1 100 ? 48.519 -48.076 19.991  1.00 14.66 ? 353 LEU C CB  1 
ATOM   2662 C CG  . LEU C 1 100 ? 48.175 -47.070 21.084  1.00 14.94 ? 353 LEU C CG  1 
ATOM   2663 C CD1 . LEU C 1 100 ? 49.347 -46.945 22.035  1.00 16.45 ? 353 LEU C CD1 1 
ATOM   2664 C CD2 . LEU C 1 100 ? 47.818 -45.711 20.514  1.00 16.29 ? 353 LEU C CD2 1 
ATOM   2665 N N   . ASN C 1 101 ? 47.993 -50.602 18.059  1.00 14.71 ? 354 ASN C N   1 
ATOM   2666 C CA  . ASN C 1 101 ? 48.361 -51.448 16.930  1.00 15.73 ? 354 ASN C CA  1 
ATOM   2667 C C   . ASN C 1 101 ? 47.244 -51.508 15.885  1.00 16.32 ? 354 ASN C C   1 
ATOM   2668 O O   . ASN C 1 101 ? 47.516 -51.690 14.712  1.00 17.78 ? 354 ASN C O   1 
ATOM   2669 C CB  . ASN C 1 101 ? 48.713 -52.864 17.389  1.00 16.88 ? 354 ASN C CB  1 
ATOM   2670 C CG  . ASN C 1 101 ? 50.092 -52.985 17.983  1.00 19.39 ? 354 ASN C CG  1 
ATOM   2671 O OD1 . ASN C 1 101 ? 50.940 -52.128 17.767  1.00 22.18 ? 354 ASN C OD1 1 
ATOM   2672 N ND2 . ASN C 1 101 ? 50.316 -54.048 18.737  1.00 21.30 ? 354 ASN C ND2 1 
ATOM   2673 N N   . LYS C 1 102 ? 45.987 -51.397 16.318  1.00 15.60 ? 355 LYS C N   1 
ATOM   2674 C CA  . LYS C 1 102 ? 44.858 -51.423 15.403  1.00 16.03 ? 355 LYS C CA  1 
ATOM   2675 C C   . LYS C 1 102 ? 44.809 -50.169 14.536  1.00 16.81 ? 355 LYS C C   1 
ATOM   2676 O O   . LYS C 1 102 ? 44.212 -50.202 13.478  1.00 17.45 ? 355 LYS C O   1 
ATOM   2677 C CB  . LYS C 1 102 ? 43.582 -51.556 16.235  1.00 19.58 ? 355 LYS C CB  1 
ATOM   2678 C CG  . LYS C 1 102 ? 42.286 -51.635 15.454  1.00 23.94 ? 355 LYS C CG  1 
ATOM   2679 C CD  . LYS C 1 102 ? 41.134 -51.919 16.386  1.00 26.00 ? 355 LYS C CD  1 
ATOM   2680 C CE  . LYS C 1 102 ? 39.969 -52.577 15.684  1.00 30.32 ? 355 LYS C CE  1 
ATOM   2681 N NZ  . LYS C 1 102 ? 38.764 -52.582 16.542  1.00 32.86 ? 355 LYS C NZ  1 
ATOM   2682 N N   . HIS C 1 103 ? 45.348 -49.040 15.010  1.00 13.80 ? 356 HIS C N   1 
ATOM   2683 C CA  . HIS C 1 103 ? 45.208 -47.762 14.321  1.00 13.64 ? 356 HIS C CA  1 
ATOM   2684 C C   . HIS C 1 103 ? 46.466 -47.317 13.579  1.00 13.45 ? 356 HIS C C   1 
ATOM   2685 O O   . HIS C 1 103 ? 46.394 -46.602 12.581  1.00 13.91 ? 356 HIS C O   1 
ATOM   2686 C CB  . HIS C 1 103 ? 44.737 -46.662 15.274  1.00 13.03 ? 356 HIS C CB  1 
ATOM   2687 C CG  . HIS C 1 103 ? 43.361 -46.906 15.750  1.00 13.18 ? 356 HIS C CG  1 
ATOM   2688 N ND1 . HIS C 1 103 ? 42.264 -46.764 14.934  1.00 13.93 ? 356 HIS C ND1 1 
ATOM   2689 C CD2 . HIS C 1 103 ? 42.901 -47.348 16.916  1.00 14.25 ? 356 HIS C CD2 1 
ATOM   2690 C CE1 . HIS C 1 103 ? 41.183 -47.074 15.644  1.00 13.87 ? 356 HIS C CE1 1 
ATOM   2691 N NE2 . HIS C 1 103 ? 41.536 -47.464 16.829  1.00 14.21 ? 356 HIS C NE2 1 
ATOM   2692 N N   . ILE C 1 104 ? 47.641 -47.739 14.054  1.00 13.53 ? 357 ILE C N   1 
ATOM   2693 C CA  . ILE C 1 104 ? 48.877 -47.318 13.406  1.00 13.50 ? 357 ILE C CA  1 
ATOM   2694 C C   . ILE C 1 104 ? 48.979 -47.992 12.050  1.00 14.28 ? 357 ILE C C   1 
ATOM   2695 O O   . ILE C 1 104 ? 49.022 -49.219 11.984  1.00 15.11 ? 357 ILE C O   1 
ATOM   2696 C CB  . ILE C 1 104 ? 50.101 -47.633 14.279  1.00 13.64 ? 357 ILE C CB  1 
ATOM   2697 C CG1 . ILE C 1 104 ? 50.083 -46.770 15.537  1.00 12.91 ? 357 ILE C CG1 1 
ATOM   2698 C CG2 . ILE C 1 104 ? 51.384 -47.453 13.489  1.00 13.45 ? 357 ILE C CG2 1 
ATOM   2699 C CD1 . ILE C 1 104 ? 51.008 -47.211 16.630  1.00 13.56 ? 357 ILE C CD1 1 
ATOM   2700 N N   . ASP C 1 105 ? 49.040 -47.202 10.975  1.00 14.65 ? 358 ASP C N   1 
ATOM   2701 C CA  . ASP C 1 105 ? 49.172 -47.708 9.613   1.00 15.32 ? 358 ASP C CA  1 
ATOM   2702 C C   . ASP C 1 105 ? 48.007 -48.618 9.221   1.00 16.06 ? 358 ASP C C   1 
ATOM   2703 O O   . ASP C 1 105 ? 48.135 -49.416 8.288   1.00 17.03 ? 358 ASP C O   1 
ATOM   2704 C CB  . ASP C 1 105 ? 50.490 -48.460 9.429   1.00 16.49 ? 358 ASP C CB  1 
ATOM   2705 C CG  . ASP C 1 105 ? 51.705 -47.572 9.335   1.00 18.59 ? 358 ASP C CG  1 
ATOM   2706 O OD1 . ASP C 1 105 ? 51.578 -46.362 9.055   1.00 17.17 ? 358 ASP C OD1 1 
ATOM   2707 O OD2 . ASP C 1 105 ? 52.817 -48.145 9.529   1.00 22.92 ? 358 ASP C OD2 1 
ATOM   2708 N N   . ALA C 1 106 ? 46.850 -48.476 9.870   1.00 15.17 ? 359 ALA C N   1 
ATOM   2709 C CA  . ALA C 1 106 ? 45.684 -49.265 9.520   1.00 16.22 ? 359 ALA C CA  1 
ATOM   2710 C C   . ALA C 1 106 ? 45.280 -49.010 8.074   1.00 18.02 ? 359 ALA C C   1 
ATOM   2711 O O   . ALA C 1 106 ? 44.726 -49.901 7.446   1.00 18.89 ? 359 ALA C O   1 
ATOM   2712 C CB  . ALA C 1 106 ? 44.547 -48.947 10.437  1.00 16.42 ? 359 ALA C CB  1 
ATOM   2713 N N   . TYR C 1 107 ? 45.551 -47.824 7.544   1.00 17.32 ? 360 TYR C N   1 
ATOM   2714 C CA  . TYR C 1 107 ? 45.144 -47.461 6.185   1.00 18.55 ? 360 TYR C CA  1 
ATOM   2715 C C   . TYR C 1 107 ? 45.742 -48.412 5.141   1.00 21.60 ? 360 TYR C C   1 
ATOM   2716 O O   . TYR C 1 107 ? 45.247 -48.495 4.029   1.00 22.94 ? 360 TYR C O   1 
ATOM   2717 C CB  . TYR C 1 107 ? 45.536 -46.028 5.843   1.00 19.52 ? 360 TYR C CB  1 
ATOM   2718 C CG  . TYR C 1 107 ? 47.008 -45.887 5.579   1.00 19.70 ? 360 TYR C CG  1 
ATOM   2719 C CD1 . TYR C 1 107 ? 47.506 -46.045 4.300   1.00 22.53 ? 360 TYR C CD1 1 
ATOM   2720 C CD2 . TYR C 1 107 ? 47.906 -45.657 6.606   1.00 19.90 ? 360 TYR C CD2 1 
ATOM   2721 C CE1 . TYR C 1 107 ? 48.862 -45.987 4.046   1.00 23.93 ? 360 TYR C CE1 1 
ATOM   2722 C CE2 . TYR C 1 107 ? 49.264 -45.569 6.369   1.00 22.04 ? 360 TYR C CE2 1 
ATOM   2723 C CZ  . TYR C 1 107 ? 49.743 -45.753 5.087   1.00 24.36 ? 360 TYR C CZ  1 
ATOM   2724 O OH  . TYR C 1 107 ? 51.081 -45.665 4.830   1.00 28.09 ? 360 TYR C OH  1 
ATOM   2725 N N   . LYS C 1 108 ? 46.816 -49.121 5.464   1.00 21.01 ? 361 LYS C N   1 
ATOM   2726 C CA  . LYS C 1 108 ? 47.403 -50.072 4.526   1.00 22.60 ? 361 LYS C CA  1 
ATOM   2727 C C   . LYS C 1 108 ? 46.442 -51.207 4.193   1.00 24.25 ? 361 LYS C C   1 
ATOM   2728 O O   . LYS C 1 108 ? 46.606 -51.837 3.150   1.00 28.34 ? 361 LYS C O   1 
ATOM   2729 C CB  . LYS C 1 108 ? 48.710 -50.627 5.095   1.00 24.86 ? 361 LYS C CB  1 
ATOM   2730 C CG  . LYS C 1 108 ? 49.810 -49.582 5.195   1.00 26.68 ? 361 LYS C CG  1 
ATOM   2731 C CD  . LYS C 1 108 ? 51.128 -50.138 5.669   1.00 31.50 ? 361 LYS C CD  1 
ATOM   2732 C CE  . LYS C 1 108 ? 52.191 -49.072 5.811   1.00 34.64 ? 361 LYS C CE  1 
ATOM   2733 N NZ  . LYS C 1 108 ? 52.645 -48.546 4.504   1.00 37.70 ? 361 LYS C NZ  1 
ATOM   2734 N N   . THR C 1 109 ? 45.434 -51.456 5.029   1.00 25.33 ? 362 THR C N   1 
ATOM   2735 C CA  . THR C 1 109 ? 44.502 -52.560 4.835   1.00 26.93 ? 362 THR C CA  1 
ATOM   2736 C C   . THR C 1 109 ? 43.208 -52.098 4.153   1.00 27.21 ? 362 THR C C   1 
ATOM   2737 O O   . THR C 1 109 ? 42.329 -52.920 3.905   1.00 29.11 ? 362 THR C O   1 
ATOM   2738 C CB  . THR C 1 109 ? 44.133 -53.231 6.171   1.00 28.35 ? 362 THR C CB  1 
ATOM   2739 O OG1 . THR C 1 109 ? 43.359 -52.344 6.979   1.00 29.70 ? 362 THR C OG1 1 
ATOM   2740 C CG2 . THR C 1 109 ? 45.324 -53.667 6.992   1.00 30.59 ? 362 THR C CG2 1 
ATOM   2741 N N   . PHE C 1 110 ? 43.053 -50.800 3.869   1.00 25.93 ? 363 PHE C N   1 
ATOM   2742 C CA  . PHE C 1 110 ? 41.752 -50.314 3.439   1.00 28.80 ? 363 PHE C CA  1 
ATOM   2743 C C   . PHE C 1 110 ? 41.526 -50.788 2.013   1.00 35.95 ? 363 PHE C C   1 
ATOM   2744 O O   . PHE C 1 110 ? 42.458 -50.762 1.207   1.00 35.09 ? 363 PHE C O   1 
ATOM   2745 C CB  . PHE C 1 110 ? 41.642 -48.789 3.491   1.00 28.46 ? 363 PHE C CB  1 
ATOM   2746 C CG  . PHE C 1 110 ? 41.706 -48.166 4.862   1.00 26.02 ? 363 PHE C CG  1 
ATOM   2747 C CD1 . PHE C 1 110 ? 41.714 -48.931 6.023   1.00 26.68 ? 363 PHE C CD1 1 
ATOM   2748 C CD2 . PHE C 1 110 ? 41.764 -46.787 4.974   1.00 25.81 ? 363 PHE C CD2 1 
ATOM   2749 C CE1 . PHE C 1 110 ? 41.829 -48.327 7.261   1.00 24.28 ? 363 PHE C CE1 1 
ATOM   2750 C CE2 . PHE C 1 110 ? 41.834 -46.183 6.216   1.00 25.29 ? 363 PHE C CE2 1 
ATOM   2751 C CZ  . PHE C 1 110 ? 41.875 -46.956 7.349   1.00 23.18 ? 363 PHE C CZ  1 
ATOM   2752 N N   . PRO C 1 111 ? 40.308 -51.282 1.691   1.00 42.10 ? 364 PRO C N   1 
ATOM   2753 C CA  . PRO C 1 111 ? 39.919 -51.554 0.308   1.00 46.98 ? 364 PRO C CA  1 
ATOM   2754 C C   . PRO C 1 111 ? 40.172 -50.353 -0.618  1.00 49.53 ? 364 PRO C C   1 
ATOM   2755 O O   . PRO C 1 111 ? 40.010 -49.234 -0.147  1.00 52.55 ? 364 PRO C O   1 
ATOM   2756 C CB  . PRO C 1 111 ? 38.413 -51.871 0.385   1.00 46.57 ? 364 PRO C CB  1 
ATOM   2757 C CG  . PRO C 1 111 ? 37.998 -51.528 1.808   1.00 45.65 ? 364 PRO C CG  1 
ATOM   2758 C CD  . PRO C 1 111 ? 39.252 -51.649 2.646   1.00 43.99 ? 364 PRO C CD  1 
ATOM   2759 O OXT . PRO C 1 111 ? 40.522 -50.604 -1.759  1.00 52.98 ? 364 PRO C OXT 1 
ATOM   2760 N N   . LYS D 1 4   ? 51.387 -36.088 37.235  1.00 31.80 ? 257 LYS D N   1 
ATOM   2761 C CA  . LYS D 1 4   ? 50.707 -36.504 35.982  1.00 29.97 ? 257 LYS D CA  1 
ATOM   2762 C C   . LYS D 1 4   ? 51.695 -37.225 35.066  1.00 25.21 ? 257 LYS D C   1 
ATOM   2763 O O   . LYS D 1 4   ? 52.915 -37.006 35.120  1.00 25.10 ? 257 LYS D O   1 
ATOM   2764 C CB  . LYS D 1 4   ? 50.089 -35.306 35.248  1.00 33.07 ? 257 LYS D CB  1 
ATOM   2765 C CG  . LYS D 1 4   ? 48.858 -34.706 35.917  1.00 36.53 ? 257 LYS D CG  1 
ATOM   2766 C CD  . LYS D 1 4   ? 48.115 -33.716 35.062  1.00 39.69 ? 257 LYS D CD  1 
ATOM   2767 C CE  . LYS D 1 4   ? 47.010 -33.010 35.817  1.00 42.62 ? 257 LYS D CE  1 
ATOM   2768 N NZ  . LYS D 1 4   ? 46.306 -32.026 34.963  1.00 45.60 ? 257 LYS D NZ  1 
ATOM   2769 N N   . PRO D 1 5   ? 51.182 -38.055 34.124  1.00 21.99 ? 258 PRO D N   1 
ATOM   2770 C CA  . PRO D 1 5   ? 51.975 -38.547 32.999  1.00 19.13 ? 258 PRO D CA  1 
ATOM   2771 C C   . PRO D 1 5   ? 52.650 -37.353 32.334  1.00 16.83 ? 258 PRO D C   1 
ATOM   2772 O O   . PRO D 1 5   ? 52.052 -36.281 32.235  1.00 15.98 ? 258 PRO D O   1 
ATOM   2773 C CB  . PRO D 1 5   ? 50.934 -39.178 32.063  1.00 20.08 ? 258 PRO D CB  1 
ATOM   2774 C CG  . PRO D 1 5   ? 49.851 -39.614 33.028  1.00 22.59 ? 258 PRO D CG  1 
ATOM   2775 C CD  . PRO D 1 5   ? 49.785 -38.491 34.031  1.00 23.56 ? 258 PRO D CD  1 
ATOM   2776 N N   A ARG D 1 6   ? 53.890 -37.563 31.877  0.50 15.24 ? 259 ARG D N   1 
ATOM   2777 N N   B ARG D 1 6   ? 53.886 -37.566 31.882  0.50 16.16 ? 259 ARG D N   1 
ATOM   2778 C CA  A ARG D 1 6   ? 54.727 -36.486 31.375  0.50 15.13 ? 259 ARG D CA  1 
ATOM   2779 C CA  B ARG D 1 6   ? 54.737 -36.505 31.376  0.50 16.78 ? 259 ARG D CA  1 
ATOM   2780 C C   A ARG D 1 6   ? 53.976 -35.651 30.337  0.50 14.64 ? 259 ARG D C   1 
ATOM   2781 C C   B ARG D 1 6   ? 54.001 -35.664 30.335  0.50 15.36 ? 259 ARG D C   1 
ATOM   2782 O O   A ARG D 1 6   ? 54.008 -34.421 30.365  0.50 13.94 ? 259 ARG D O   1 
ATOM   2783 O O   B ARG D 1 6   ? 54.056 -34.438 30.375  0.50 14.30 ? 259 ARG D O   1 
ATOM   2784 C CB  A ARG D 1 6   ? 56.022 -37.069 30.796  0.50 15.59 ? 259 ARG D CB  1 
ATOM   2785 C CB  B ARG D 1 6   ? 56.010 -37.131 30.803  0.50 18.96 ? 259 ARG D CB  1 
ATOM   2786 C CG  A ARG D 1 6   ? 57.042 -36.022 30.361  0.50 15.75 ? 259 ARG D CG  1 
ATOM   2787 C CG  B ARG D 1 6   ? 57.169 -36.163 30.631  0.50 21.09 ? 259 ARG D CG  1 
ATOM   2788 C CD  A ARG D 1 6   ? 58.263 -36.657 29.713  0.50 15.59 ? 259 ARG D CD  1 
ATOM   2789 C CD  B ARG D 1 6   ? 58.385 -36.880 30.067  0.50 22.64 ? 259 ARG D CD  1 
ATOM   2790 N NE  A ARG D 1 6   ? 59.345 -35.711 29.494  0.50 15.28 ? 259 ARG D NE  1 
ATOM   2791 N NE  B ARG D 1 6   ? 59.643 -36.196 30.319  0.50 24.27 ? 259 ARG D NE  1 
ATOM   2792 C CZ  A ARG D 1 6   ? 60.064 -35.622 28.389  0.50 13.85 ? 259 ARG D CZ  1 
ATOM   2793 C CZ  B ARG D 1 6   ? 60.258 -36.152 31.496  0.50 23.80 ? 259 ARG D CZ  1 
ATOM   2794 N NH1 A ARG D 1 6   ? 59.864 -36.430 27.364  0.50 14.83 ? 259 ARG D NH1 1 
ATOM   2795 N NH1 B ARG D 1 6   ? 61.305 -35.369 31.649  0.50 22.57 ? 259 ARG D NH1 1 
ATOM   2796 N NH2 A ARG D 1 6   ? 60.940 -34.655 28.293  0.50 11.88 ? 259 ARG D NH2 1 
ATOM   2797 N NH2 B ARG D 1 6   ? 59.812 -36.864 32.517  0.50 25.00 ? 259 ARG D NH2 1 
ATOM   2798 N N   . GLN D 1 7   ? 53.291 -36.325 29.412  1.00 13.85 ? 260 GLN D N   1 
ATOM   2799 C CA  . GLN D 1 7   ? 52.666 -35.656 28.290  1.00 13.04 ? 260 GLN D CA  1 
ATOM   2800 C C   . GLN D 1 7   ? 51.507 -34.756 28.704  1.00 12.79 ? 260 GLN D C   1 
ATOM   2801 O O   . GLN D 1 7   ? 51.058 -33.948 27.893  1.00 13.45 ? 260 GLN D O   1 
ATOM   2802 C CB  . GLN D 1 7   ? 52.221 -36.671 27.241  1.00 13.50 ? 260 GLN D CB  1 
ATOM   2803 C CG  . GLN D 1 7   ? 51.084 -37.586 27.669  1.00 13.44 ? 260 GLN D CG  1 
ATOM   2804 C CD  . GLN D 1 7   ? 51.503 -38.844 28.384  1.00 13.34 ? 260 GLN D CD  1 
ATOM   2805 O OE1 . GLN D 1 7   ? 52.624 -38.976 28.869  1.00 13.22 ? 260 GLN D OE1 1 
ATOM   2806 N NE2 . GLN D 1 7   ? 50.598 -39.797 28.455  1.00 13.03 ? 260 GLN D NE2 1 
ATOM   2807 N N   . LYS D 1 8   ? 50.994 -34.900 29.938  1.00 13.64 ? 261 LYS D N   1 
ATOM   2808 C CA  . LYS D 1 8   ? 49.883 -34.078 30.379  1.00 14.28 ? 261 LYS D CA  1 
ATOM   2809 C C   . LYS D 1 8   ? 50.335 -32.990 31.346  1.00 14.99 ? 261 LYS D C   1 
ATOM   2810 O O   . LYS D 1 8   ? 49.499 -32.256 31.871  1.00 16.50 ? 261 LYS D O   1 
ATOM   2811 C CB  . LYS D 1 8   ? 48.793 -34.941 31.022  1.00 15.32 ? 261 LYS D CB  1 
ATOM   2812 C CG  . LYS D 1 8   ? 48.088 -35.873 30.045  1.00 15.85 ? 261 LYS D CG  1 
ATOM   2813 C CD  . LYS D 1 8   ? 47.523 -35.198 28.806  1.00 15.58 ? 261 LYS D CD  1 
ATOM   2814 C CE  . LYS D 1 8   ? 46.607 -36.133 28.041  1.00 16.00 ? 261 LYS D CE  1 
ATOM   2815 N NZ  . LYS D 1 8   ? 46.164 -35.580 26.746  1.00 17.10 ? 261 LYS D NZ  1 
ATOM   2816 N N   . ARG D 1 9   ? 51.634 -32.907 31.625  1.00 14.85 ? 262 ARG D N   1 
ATOM   2817 C CA  . ARG D 1 9   ? 52.136 -31.928 32.578  1.00 15.44 ? 262 ARG D CA  1 
ATOM   2818 C C   . ARG D 1 9   ? 51.999 -30.519 32.027  1.00 15.50 ? 262 ARG D C   1 
ATOM   2819 O O   . ARG D 1 9   ? 52.040 -30.291 30.823  1.00 15.18 ? 262 ARG D O   1 
ATOM   2820 C CB  . ARG D 1 9   ? 53.594 -32.189 32.930  1.00 16.10 ? 262 ARG D CB  1 
ATOM   2821 C CG  . ARG D 1 9   ? 53.764 -33.453 33.741  1.00 16.57 ? 262 ARG D CG  1 
ATOM   2822 C CD  . ARG D 1 9   ? 55.202 -33.849 33.931  1.00 16.92 ? 262 ARG D CD  1 
ATOM   2823 N NE  . ARG D 1 9   ? 55.277 -35.144 34.586  1.00 18.13 ? 262 ARG D NE  1 
ATOM   2824 C CZ  . ARG D 1 9   ? 56.398 -35.800 34.832  1.00 22.44 ? 262 ARG D CZ  1 
ATOM   2825 N NH1 . ARG D 1 9   ? 56.321 -36.982 35.417  1.00 26.08 ? 262 ARG D NH1 1 
ATOM   2826 N NH2 . ARG D 1 9   ? 57.580 -35.271 34.534  1.00 21.95 ? 262 ARG D NH2 1 
ATOM   2827 N N   . THR D 1 10  ? 51.879 -29.572 32.958  1.00 17.32 ? 263 THR D N   1 
ATOM   2828 C CA  . THR D 1 10  ? 51.866 -28.158 32.649  1.00 17.11 ? 263 THR D CA  1 
ATOM   2829 C C   . THR D 1 10  ? 53.017 -27.507 33.397  1.00 16.77 ? 263 THR D C   1 
ATOM   2830 O O   . THR D 1 10  ? 53.001 -27.453 34.624  1.00 18.38 ? 263 THR D O   1 
ATOM   2831 C CB  . THR D 1 10  ? 50.533 -27.528 33.056  1.00 19.81 ? 263 THR D CB  1 
ATOM   2832 O OG1 . THR D 1 10  ? 49.478 -28.276 32.449  1.00 22.02 ? 263 THR D OG1 1 
ATOM   2833 C CG2 . THR D 1 10  ? 50.421 -26.078 32.654  1.00 21.34 ? 263 THR D CG2 1 
ATOM   2834 N N   . ALA D 1 11  ? 54.005 -27.008 32.656  1.00 15.17 ? 264 ALA D N   1 
ATOM   2835 C CA  . ALA D 1 11  ? 55.098 -26.296 33.291  1.00 15.69 ? 264 ALA D CA  1 
ATOM   2836 C C   . ALA D 1 11  ? 54.614 -24.916 33.715  1.00 15.41 ? 264 ALA D C   1 
ATOM   2837 O O   . ALA D 1 11  ? 53.829 -24.283 33.018  1.00 15.70 ? 264 ALA D O   1 
ATOM   2838 C CB  . ALA D 1 11  ? 56.295 -26.184 32.388  1.00 15.23 ? 264 ALA D CB  1 
ATOM   2839 N N   . THR D 1 12  ? 55.114 -24.483 34.883  1.00 16.98 ? 265 THR D N   1 
ATOM   2840 C CA  . THR D 1 12  ? 54.825 -23.183 35.456  1.00 18.21 ? 265 THR D CA  1 
ATOM   2841 C C   . THR D 1 12  ? 56.080 -22.724 36.192  1.00 16.76 ? 265 THR D C   1 
ATOM   2842 O O   . THR D 1 12  ? 57.056 -23.450 36.296  1.00 16.89 ? 265 THR D O   1 
ATOM   2843 C CB  . THR D 1 12  ? 53.660 -23.261 36.450  1.00 19.83 ? 265 THR D CB  1 
ATOM   2844 O OG1 . THR D 1 12  ? 54.083 -24.053 37.547  1.00 21.15 ? 265 THR D OG1 1 
ATOM   2845 C CG2 . THR D 1 12  ? 52.393 -23.836 35.865  1.00 20.80 ? 265 THR D CG2 1 
ATOM   2846 N N   . LYS D 1 13  ? 56.001 -21.553 36.823  1.00 18.51 ? 266 LYS D N   1 
ATOM   2847 C CA  . LYS D 1 13  ? 57.109 -21.077 37.635  1.00 19.49 ? 266 LYS D CA  1 
ATOM   2848 C C   . LYS D 1 13  ? 57.370 -22.048 38.778  1.00 19.59 ? 266 LYS D C   1 
ATOM   2849 O O   . LYS D 1 13  ? 58.521 -22.266 39.130  1.00 20.63 ? 266 LYS D O   1 
ATOM   2850 C CB  . LYS D 1 13  ? 56.835 -19.662 38.148  1.00 20.66 ? 266 LYS D CB  1 
ATOM   2851 C CG  . LYS D 1 13  ? 56.938 -18.594 37.072  1.00 22.54 ? 266 LYS D CG  1 
ATOM   2852 C CD  . LYS D 1 13  ? 56.495 -17.228 37.527  1.00 24.67 ? 266 LYS D CD  1 
ATOM   2853 C CE  . LYS D 1 13  ? 56.351 -16.269 36.369  1.00 26.92 ? 266 LYS D CE  1 
ATOM   2854 N NZ  . LYS D 1 13  ? 55.832 -14.960 36.816  1.00 28.74 ? 266 LYS D NZ  1 
ATOM   2855 N N   . ALA D 1 14  ? 56.312 -22.656 39.322  1.00 21.05 ? 267 ALA D N   1 
ATOM   2856 C CA  . ALA D 1 14  ? 56.434 -23.569 40.447  1.00 22.60 ? 267 ALA D CA  1 
ATOM   2857 C C   . ALA D 1 14  ? 56.947 -24.944 40.032  1.00 23.55 ? 267 ALA D C   1 
ATOM   2858 O O   . ALA D 1 14  ? 57.451 -25.698 40.853  1.00 24.45 ? 267 ALA D O   1 
ATOM   2859 C CB  . ALA D 1 14  ? 55.092 -23.698 41.114  1.00 23.48 ? 267 ALA D CB  1 
ATOM   2860 N N   . TYR D 1 15  ? 56.789 -25.284 38.748  1.00 21.28 ? 268 TYR D N   1 
ATOM   2861 C CA  . TYR D 1 15  ? 57.143 -26.591 38.223  1.00 19.97 ? 268 TYR D CA  1 
ATOM   2862 C C   . TYR D 1 15  ? 57.617 -26.372 36.798  1.00 18.52 ? 268 TYR D C   1 
ATOM   2863 O O   . TYR D 1 15  ? 56.814 -26.440 35.861  1.00 19.02 ? 268 TYR D O   1 
ATOM   2864 C CB  . TYR D 1 15  ? 55.925 -27.507 38.279  1.00 19.98 ? 268 TYR D CB  1 
ATOM   2865 C CG  . TYR D 1 15  ? 56.135 -28.938 37.876  1.00 19.42 ? 268 TYR D CG  1 
ATOM   2866 C CD1 . TYR D 1 15  ? 57.140 -29.717 38.425  1.00 20.53 ? 268 TYR D CD1 1 
ATOM   2867 C CD2 . TYR D 1 15  ? 55.271 -29.541 36.980  1.00 18.63 ? 268 TYR D CD2 1 
ATOM   2868 C CE1 . TYR D 1 15  ? 57.286 -31.051 38.092  1.00 20.38 ? 268 TYR D CE1 1 
ATOM   2869 C CE2 . TYR D 1 15  ? 55.405 -30.870 36.631  1.00 19.81 ? 268 TYR D CE2 1 
ATOM   2870 C CZ  . TYR D 1 15  ? 56.427 -31.621 37.171  1.00 20.06 ? 268 TYR D CZ  1 
ATOM   2871 O OH  . TYR D 1 15  ? 56.562 -32.932 36.834  1.00 21.55 ? 268 TYR D OH  1 
ATOM   2872 N N   . ASN D 1 16  ? 58.896 -26.023 36.644  1.00 17.53 ? 269 ASN D N   1 
ATOM   2873 C CA  . ASN D 1 16  ? 59.337 -25.359 35.431  1.00 17.04 ? 269 ASN D CA  1 
ATOM   2874 C C   . ASN D 1 16  ? 59.626 -26.383 34.338  1.00 15.93 ? 269 ASN D C   1 
ATOM   2875 O O   . ASN D 1 16  ? 59.406 -27.576 34.495  1.00 16.48 ? 269 ASN D O   1 
ATOM   2876 C CB  . ASN D 1 16  ? 60.485 -24.402 35.726  1.00 17.74 ? 269 ASN D CB  1 
ATOM   2877 C CG  . ASN D 1 16  ? 61.764 -25.098 36.114  1.00 19.41 ? 269 ASN D CG  1 
ATOM   2878 O OD1 . ASN D 1 16  ? 62.040 -26.191 35.652  1.00 19.45 ? 269 ASN D OD1 1 
ATOM   2879 N ND2 . ASN D 1 16  ? 62.543 -24.511 37.016  1.00 22.17 ? 269 ASN D ND2 1 
ATOM   2880 N N   . VAL D 1 17  ? 60.068 -25.899 33.180  1.00 15.37 ? 270 VAL D N   1 
ATOM   2881 C CA  . VAL D 1 17  ? 60.223 -26.782 32.037  1.00 14.96 ? 270 VAL D CA  1 
ATOM   2882 C C   . VAL D 1 17  ? 61.253 -27.862 32.338  1.00 15.34 ? 270 VAL D C   1 
ATOM   2883 O O   . VAL D 1 17  ? 61.083 -28.998 31.931  1.00 14.97 ? 270 VAL D O   1 
ATOM   2884 C CB  . VAL D 1 17  ? 60.575 -25.981 30.776  1.00 14.36 ? 270 VAL D CB  1 
ATOM   2885 C CG1 . VAL D 1 17  ? 60.972 -26.870 29.616  1.00 14.28 ? 270 VAL D CG1 1 
ATOM   2886 C CG2 . VAL D 1 17  ? 59.420 -25.087 30.377  1.00 14.49 ? 270 VAL D CG2 1 
ATOM   2887 N N   . THR D 1 18  ? 62.337 -27.504 33.027  1.00 16.06 ? 271 THR D N   1 
ATOM   2888 C CA  . THR D 1 18  ? 63.330 -28.498 33.399  1.00 17.39 ? 271 THR D CA  1 
ATOM   2889 C C   . THR D 1 18  ? 62.751 -29.534 34.355  1.00 17.17 ? 271 THR D C   1 
ATOM   2890 O O   . THR D 1 18  ? 62.971 -30.725 34.172  1.00 18.12 ? 271 THR D O   1 
ATOM   2891 C CB  . THR D 1 18  ? 64.557 -27.841 34.031  1.00 18.80 ? 271 THR D CB  1 
ATOM   2892 O OG1 . THR D 1 18  ? 65.063 -26.918 33.071  1.00 19.90 ? 271 THR D OG1 1 
ATOM   2893 C CG2 . THR D 1 18  ? 65.629 -28.841 34.404  1.00 21.10 ? 271 THR D CG2 1 
ATOM   2894 N N   . GLN D 1 19  ? 61.988 -29.070 35.347  1.00 17.50 ? 272 GLN D N   1 
ATOM   2895 C CA  . GLN D 1 19  ? 61.431 -29.968 36.344  1.00 18.69 ? 272 GLN D CA  1 
ATOM   2896 C C   . GLN D 1 19  ? 60.427 -30.921 35.690  1.00 17.19 ? 272 GLN D C   1 
ATOM   2897 O O   . GLN D 1 19  ? 60.389 -32.111 36.001  1.00 18.76 ? 272 GLN D O   1 
ATOM   2898 C CB  . GLN D 1 19  ? 60.795 -29.160 37.465  1.00 19.60 ? 272 GLN D CB  1 
ATOM   2899 C CG  . GLN D 1 19  ? 61.817 -28.368 38.275  1.00 21.85 ? 272 GLN D CG  1 
ATOM   2900 C CD  . GLN D 1 19  ? 61.166 -27.475 39.295  1.00 24.33 ? 272 GLN D CD  1 
ATOM   2901 O OE1 . GLN D 1 19  ? 60.447 -26.541 38.979  1.00 23.17 ? 272 GLN D OE1 1 
ATOM   2902 N NE2 . GLN D 1 19  ? 61.405 -27.778 40.564  1.00 29.47 ? 272 GLN D NE2 1 
ATOM   2903 N N   . ALA D 1 20  ? 59.607 -30.395 34.769  1.00 16.26 ? 273 ALA D N   1 
ATOM   2904 C CA  . ALA D 1 20  ? 58.543 -31.180 34.167  1.00 15.82 ? 273 ALA D CA  1 
ATOM   2905 C C   . ALA D 1 20  ? 59.044 -32.054 33.025  1.00 14.25 ? 273 ALA D C   1 
ATOM   2906 O O   . ALA D 1 20  ? 58.552 -33.164 32.848  1.00 15.69 ? 273 ALA D O   1 
ATOM   2907 C CB  . ALA D 1 20  ? 57.465 -30.255 33.660  1.00 16.06 ? 273 ALA D CB  1 
ATOM   2908 N N   . PHE D 1 21  ? 59.981 -31.536 32.231  1.00 14.04 ? 274 PHE D N   1 
ATOM   2909 C CA  . PHE D 1 21  ? 60.296 -32.126 30.940  1.00 14.99 ? 274 PHE D CA  1 
ATOM   2910 C C   . PHE D 1 21  ? 61.784 -32.374 30.721  1.00 15.59 ? 274 PHE D C   1 
ATOM   2911 O O   . PHE D 1 21  ? 62.183 -32.778 29.633  1.00 15.74 ? 274 PHE D O   1 
ATOM   2912 C CB  . PHE D 1 21  ? 59.766 -31.233 29.812  1.00 14.49 ? 274 PHE D CB  1 
ATOM   2913 C CG  . PHE D 1 21  ? 58.298 -30.944 29.915  1.00 13.78 ? 274 PHE D CG  1 
ATOM   2914 C CD1 . PHE D 1 21  ? 57.811 -29.657 30.025  1.00 14.00 ? 274 PHE D CD1 1 
ATOM   2915 C CD2 . PHE D 1 21  ? 57.396 -31.989 29.937  1.00 13.17 ? 274 PHE D CD2 1 
ATOM   2916 C CE1 . PHE D 1 21  ? 56.445 -29.427 30.115  1.00 13.71 ? 274 PHE D CE1 1 
ATOM   2917 C CE2 . PHE D 1 21  ? 56.043 -31.759 30.057  1.00 13.23 ? 274 PHE D CE2 1 
ATOM   2918 C CZ  . PHE D 1 21  ? 55.563 -30.480 30.152  1.00 13.09 ? 274 PHE D CZ  1 
ATOM   2919 N N   . GLY D 1 22  ? 62.604 -32.119 31.741  1.00 16.38 ? 275 GLY D N   1 
ATOM   2920 C CA  . GLY D 1 22  ? 64.027 -32.392 31.648  1.00 17.37 ? 275 GLY D CA  1 
ATOM   2921 C C   . GLY D 1 22  ? 64.812 -31.241 31.019  1.00 17.81 ? 275 GLY D C   1 
ATOM   2922 O O   . GLY D 1 22  ? 64.256 -30.340 30.398  1.00 16.10 ? 275 GLY D O   1 
ATOM   2923 N N   . ARG D 1 23  ? 66.133 -31.287 31.182  1.00 19.20 ? 276 ARG D N   1 
ATOM   2924 C CA  . ARG D 1 23  ? 66.978 -30.256 30.609  1.00 19.86 ? 276 ARG D CA  1 
ATOM   2925 C C   . ARG D 1 23  ? 66.870 -30.291 29.087  1.00 16.51 ? 276 ARG D C   1 
ATOM   2926 O O   . ARG D 1 23  ? 66.778 -31.351 28.495  1.00 17.92 ? 276 ARG D O   1 
ATOM   2927 C CB  . ARG D 1 23  ? 68.424 -30.423 31.085  1.00 25.77 ? 276 ARG D CB  1 
ATOM   2928 C CG  . ARG D 1 23  ? 68.637 -29.888 32.489  1.00 30.62 ? 276 ARG D CG  1 
ATOM   2929 C CD  . ARG D 1 23  ? 70.058 -29.496 32.792  1.00 35.89 ? 276 ARG D CD  1 
ATOM   2930 N NE  . ARG D 1 23  ? 70.946 -30.641 32.735  1.00 40.66 ? 276 ARG D NE  1 
ATOM   2931 C CZ  . ARG D 1 23  ? 72.245 -30.592 33.004  1.00 42.13 ? 276 ARG D CZ  1 
ATOM   2932 N NH1 . ARG D 1 23  ? 72.783 -29.490 33.499  1.00 42.13 ? 276 ARG D NH1 1 
ATOM   2933 N NH2 . ARG D 1 23  ? 73.006 -31.651 32.780  1.00 44.79 ? 276 ARG D NH2 1 
ATOM   2934 N N   . ARG D 1 24  ? 66.920 -29.102 28.486  1.00 15.35 ? 277 ARG D N   1 
ATOM   2935 C CA  . ARG D 1 24  ? 67.009 -28.978 27.045  1.00 15.07 ? 277 ARG D CA  1 
ATOM   2936 C C   . ARG D 1 24  ? 68.340 -29.532 26.569  1.00 15.26 ? 277 ARG D C   1 
ATOM   2937 O O   . ARG D 1 24  ? 69.349 -29.422 27.258  1.00 16.15 ? 277 ARG D O   1 
ATOM   2938 C CB  . ARG D 1 24  ? 66.875 -27.524 26.595  1.00 14.80 ? 277 ARG D CB  1 
ATOM   2939 C CG  . ARG D 1 24  ? 65.447 -27.059 26.370  1.00 14.75 ? 277 ARG D CG  1 
ATOM   2940 C CD  . ARG D 1 24  ? 64.587 -26.852 27.590  1.00 14.10 ? 277 ARG D CD  1 
ATOM   2941 N NE  . ARG D 1 24  ? 64.059 -28.102 28.064  1.00 14.16 ? 277 ARG D NE  1 
ATOM   2942 C CZ  . ARG D 1 24  ? 63.073 -28.782 27.499  1.00 13.73 ? 277 ARG D CZ  1 
ATOM   2943 N NH1 . ARG D 1 24  ? 62.729 -29.945 27.997  1.00 14.10 ? 277 ARG D NH1 1 
ATOM   2944 N NH2 . ARG D 1 24  ? 62.467 -28.330 26.409  1.00 12.92 ? 277 ARG D NH2 1 
ATOM   2945 N N   . GLY D 1 25  ? 68.357 -30.091 25.369  1.00 15.19 ? 278 GLY D N   1 
ATOM   2946 C CA  . GLY D 1 25  ? 69.596 -30.564 24.790  1.00 15.19 ? 278 GLY D CA  1 
ATOM   2947 C C   . GLY D 1 25  ? 69.414 -31.126 23.394  1.00 15.52 ? 278 GLY D C   1 
ATOM   2948 O O   . GLY D 1 25  ? 68.339 -31.030 22.811  1.00 15.79 ? 278 GLY D O   1 
ATOM   2949 N N   . PRO D 1 26  ? 70.497 -31.689 22.818  1.00 15.95 ? 279 PRO D N   1 
ATOM   2950 C CA  . PRO D 1 26  ? 70.506 -32.102 21.419  1.00 15.99 ? 279 PRO D CA  1 
ATOM   2951 C C   . PRO D 1 26  ? 70.108 -33.548 21.138  1.00 16.67 ? 279 PRO D C   1 
ATOM   2952 O O   . PRO D 1 26  ? 69.980 -33.925 19.972  1.00 17.05 ? 279 PRO D O   1 
ATOM   2953 C CB  . PRO D 1 26  ? 71.978 -31.921 21.030  1.00 17.31 ? 279 PRO D CB  1 
ATOM   2954 C CG  . PRO D 1 26  ? 72.705 -32.270 22.297  1.00 16.91 ? 279 PRO D CG  1 
ATOM   2955 C CD  . PRO D 1 26  ? 71.831 -31.769 23.434  1.00 16.43 ? 279 PRO D CD  1 
ATOM   2956 N N   . GLU D 1 27  ? 69.917 -34.345 22.198  1.00 16.98 ? 280 GLU D N   1 
ATOM   2957 C CA  . GLU D 1 27  ? 69.733 -35.779 22.020  1.00 17.66 ? 280 GLU D CA  1 
ATOM   2958 C C   . GLU D 1 27  ? 68.357 -36.086 21.445  1.00 18.39 ? 280 GLU D C   1 
ATOM   2959 O O   . GLU D 1 27  ? 67.431 -35.280 21.521  1.00 18.54 ? 280 GLU D O   1 
ATOM   2960 C CB  . GLU D 1 27  ? 69.996 -36.532 23.324  1.00 17.83 ? 280 GLU D CB  1 
ATOM   2961 C CG  . GLU D 1 27  ? 71.397 -36.310 23.868  1.00 18.83 ? 280 GLU D CG  1 
ATOM   2962 C CD  . GLU D 1 27  ? 72.562 -36.614 22.936  1.00 17.77 ? 280 GLU D CD  1 
ATOM   2963 O OE1 . GLU D 1 27  ? 73.574 -35.875 22.984  1.00 20.37 ? 280 GLU D OE1 1 
ATOM   2964 O OE2 . GLU D 1 27  ? 72.478 -37.606 22.161  1.00 19.85 ? 280 GLU D OE2 1 
ATOM   2965 N N   . GLN D 1 28  ? 68.234 -37.277 20.869  1.00 19.98 ? 281 GLN D N   1 
ATOM   2966 C CA  . GLN D 1 28  ? 67.161 -37.575 19.934  1.00 25.13 ? 281 GLN D CA  1 
ATOM   2967 C C   . GLN D 1 28  ? 65.779 -37.443 20.553  1.00 26.67 ? 281 GLN D C   1 
ATOM   2968 O O   . GLN D 1 28  ? 64.855 -37.037 19.848  1.00 29.18 ? 281 GLN D O   1 
ATOM   2969 C CB  . GLN D 1 28  ? 67.317 -38.966 19.324  1.00 29.39 ? 281 GLN D CB  1 
ATOM   2970 C CG  . GLN D 1 28  ? 66.540 -39.131 18.023  1.00 35.71 ? 281 GLN D CG  1 
ATOM   2971 C CD  . GLN D 1 28  ? 66.483 -37.876 17.177  1.00 39.81 ? 281 GLN D CD  1 
ATOM   2972 O OE1 . GLN D 1 28  ? 67.495 -37.379 16.681  1.00 45.61 ? 281 GLN D OE1 1 
ATOM   2973 N NE2 . GLN D 1 28  ? 65.283 -37.341 17.011  1.00 40.29 ? 281 GLN D NE2 1 
ATOM   2974 N N   . THR D 1 29  ? 65.591 -37.849 21.810  1.00 24.94 ? 282 THR D N   1 
ATOM   2975 C CA  . THR D 1 29  ? 64.249 -37.749 22.382  1.00 24.71 ? 282 THR D CA  1 
ATOM   2976 C C   . THR D 1 29  ? 64.252 -36.721 23.506  1.00 25.88 ? 282 THR D C   1 
ATOM   2977 O O   . THR D 1 29  ? 63.342 -36.718 24.336  1.00 29.01 ? 282 THR D O   1 
ATOM   2978 C CB  . THR D 1 29  ? 63.681 -39.120 22.779  1.00 24.35 ? 282 THR D CB  1 
ATOM   2979 O OG1 . THR D 1 29  ? 64.603 -39.729 23.675  1.00 24.50 ? 282 THR D OG1 1 
ATOM   2980 C CG2 . THR D 1 29  ? 63.451 -40.019 21.587  1.00 23.83 ? 282 THR D CG2 1 
ATOM   2981 N N   . GLN D 1 30  ? 65.262 -35.843 23.509  1.00 24.40 ? 283 GLN D N   1 
ATOM   2982 C CA  . GLN D 1 30  ? 65.381 -34.745 24.461  1.00 22.39 ? 283 GLN D CA  1 
ATOM   2983 C C   . GLN D 1 30  ? 64.750 -33.487 23.881  1.00 17.04 ? 283 GLN D C   1 
ATOM   2984 O O   . GLN D 1 30  ? 64.961 -33.212 22.713  1.00 18.23 ? 283 GLN D O   1 
ATOM   2985 C CB  . GLN D 1 30  ? 66.860 -34.429 24.631  1.00 24.64 ? 283 GLN D CB  1 
ATOM   2986 C CG  . GLN D 1 30  ? 67.226 -33.584 25.818  1.00 23.90 ? 283 GLN D CG  1 
ATOM   2987 C CD  . GLN D 1 30  ? 68.725 -33.552 26.043  1.00 23.36 ? 283 GLN D CD  1 
ATOM   2988 O OE1 . GLN D 1 30  ? 69.560 -33.827 25.169  1.00 20.61 ? 283 GLN D OE1 1 
ATOM   2989 N NE2 . GLN D 1 30  ? 69.090 -33.098 27.229  1.00 26.04 ? 283 GLN D NE2 1 
ATOM   2990 N N   . GLY D 1 31  ? 64.040 -32.702 24.699  1.00 14.47 ? 284 GLY D N   1 
ATOM   2991 C CA  . GLY D 1 31  ? 63.457 -31.443 24.232  1.00 13.55 ? 284 GLY D CA  1 
ATOM   2992 C C   . GLY D 1 31  ? 64.532 -30.402 23.935  1.00 13.14 ? 284 GLY D C   1 
ATOM   2993 O O   . GLY D 1 31  ? 65.513 -30.327 24.659  1.00 14.29 ? 284 GLY D O   1 
ATOM   2994 N N   . ASN D 1 32  ? 64.348 -29.596 22.888  1.00 12.23 ? 285 ASN D N   1 
ATOM   2995 C CA  . ASN D 1 32  ? 65.317 -28.578 22.537  1.00 11.80 ? 285 ASN D CA  1 
ATOM   2996 C C   . ASN D 1 32  ? 64.729 -27.172 22.578  1.00 11.58 ? 285 ASN D C   1 
ATOM   2997 O O   . ASN D 1 32  ? 65.414 -26.227 22.173  1.00 12.39 ? 285 ASN D O   1 
ATOM   2998 C CB  . ASN D 1 32  ? 65.892 -28.818 21.147  1.00 11.80 ? 285 ASN D CB  1 
ATOM   2999 C CG  . ASN D 1 32  ? 64.870 -28.602 20.055  1.00 12.29 ? 285 ASN D CG  1 
ATOM   3000 O OD1 . ASN D 1 32  ? 63.679 -28.748 20.281  1.00 12.16 ? 285 ASN D OD1 1 
ATOM   3001 N ND2 . ASN D 1 32  ? 65.327 -28.222 18.879  1.00 13.25 ? 285 ASN D ND2 1 
ATOM   3002 N N   . PHE D 1 33  ? 63.494 -27.011 23.056  1.00 11.58 ? 286 PHE D N   1 
ATOM   3003 C CA  . PHE D 1 33  ? 62.797 -25.750 22.907  1.00 11.30 ? 286 PHE D CA  1 
ATOM   3004 C C   . PHE D 1 33  ? 62.748 -25.011 24.235  1.00 11.64 ? 286 PHE D C   1 
ATOM   3005 O O   . PHE D 1 33  ? 62.301 -25.540 25.244  1.00 12.31 ? 286 PHE D O   1 
ATOM   3006 C CB  . PHE D 1 33  ? 61.396 -26.012 22.378  1.00 11.77 ? 286 PHE D CB  1 
ATOM   3007 C CG  . PHE D 1 33  ? 60.610 -24.790 21.983  1.00 11.38 ? 286 PHE D CG  1 
ATOM   3008 C CD1 . PHE D 1 33  ? 59.826 -24.103 22.898  1.00 11.54 ? 286 PHE D CD1 1 
ATOM   3009 C CD2 . PHE D 1 33  ? 60.616 -24.367 20.663  1.00 11.61 ? 286 PHE D CD2 1 
ATOM   3010 C CE1 . PHE D 1 33  ? 59.050 -23.023 22.480  1.00 11.77 ? 286 PHE D CE1 1 
ATOM   3011 C CE2 . PHE D 1 33  ? 59.856 -23.284 20.255  1.00 11.84 ? 286 PHE D CE2 1 
ATOM   3012 C CZ  . PHE D 1 33  ? 59.060 -22.627 21.160  1.00 11.87 ? 286 PHE D CZ  1 
ATOM   3013 N N   . GLY D 1 34  ? 63.159 -23.748 24.166  1.00 11.60 ? 287 GLY D N   1 
ATOM   3014 C CA  . GLY D 1 34  ? 62.951 -22.797 25.234  1.00 12.70 ? 287 GLY D CA  1 
ATOM   3015 C C   . GLY D 1 34  ? 64.230 -22.067 25.589  1.00 13.01 ? 287 GLY D C   1 
ATOM   3016 O O   . GLY D 1 34  ? 65.274 -22.687 25.782  1.00 13.04 ? 287 GLY D O   1 
ATOM   3017 N N   . ASP D 1 35  ? 64.130 -20.739 25.647  1.00 12.79 ? 288 ASP D N   1 
ATOM   3018 C CA  . ASP D 1 35  ? 65.213 -19.924 26.194  1.00 13.37 ? 288 ASP D CA  1 
ATOM   3019 C C   . ASP D 1 35  ? 65.088 -19.925 27.713  1.00 12.82 ? 288 ASP D C   1 
ATOM   3020 O O   . ASP D 1 35  ? 64.249 -20.591 28.306  1.00 13.62 ? 288 ASP D O   1 
ATOM   3021 C CB  . ASP D 1 35  ? 65.188 -18.526 25.564  1.00 14.32 ? 288 ASP D CB  1 
ATOM   3022 C CG  . ASP D 1 35  ? 64.064 -17.618 26.014  1.00 14.54 ? 288 ASP D CG  1 
ATOM   3023 O OD1 . ASP D 1 35  ? 64.040 -16.471 25.498  1.00 16.71 ? 288 ASP D OD1 1 
ATOM   3024 O OD2 . ASP D 1 35  ? 63.286 -18.014 26.873  1.00 14.76 ? 288 ASP D OD2 1 
ATOM   3025 N N   . GLN D 1 36  ? 65.971 -19.175 28.392  1.00 14.36 ? 289 GLN D N   1 
ATOM   3026 C CA  . GLN D 1 36  ? 66.009 -19.245 29.839  1.00 14.61 ? 289 GLN D CA  1 
ATOM   3027 C C   . GLN D 1 36  ? 64.713 -18.751 30.468  1.00 14.20 ? 289 GLN D C   1 
ATOM   3028 O O   . GLN D 1 36  ? 64.269 -19.294 31.472  1.00 14.93 ? 289 GLN D O   1 
ATOM   3029 C CB  . GLN D 1 36  ? 67.211 -18.479 30.381  1.00 16.84 ? 289 GLN D CB  1 
ATOM   3030 C CG  . GLN D 1 36  ? 68.500 -19.221 30.092  1.00 19.07 ? 289 GLN D CG  1 
ATOM   3031 C CD  . GLN D 1 36  ? 69.722 -18.751 30.835  1.00 24.72 ? 289 GLN D CD  1 
ATOM   3032 O OE1 . GLN D 1 36  ? 70.203 -17.642 30.619  1.00 30.34 ? 289 GLN D OE1 1 
ATOM   3033 N NE2 . GLN D 1 36  ? 70.241 -19.605 31.710  1.00 25.42 ? 289 GLN D NE2 1 
ATOM   3034 N N   . GLU D 1 37  ? 64.095 -17.745 29.847  1.00 15.19 ? 290 GLU D N   1 
ATOM   3035 C CA  . GLU D 1 37  ? 62.886 -17.179 30.410  1.00 15.62 ? 290 GLU D CA  1 
ATOM   3036 C C   . GLU D 1 37  ? 61.735 -18.190 30.337  1.00 13.55 ? 290 GLU D C   1 
ATOM   3037 O O   . GLU D 1 37  ? 61.035 -18.436 31.317  1.00 15.17 ? 290 GLU D O   1 
ATOM   3038 C CB  . GLU D 1 37  ? 62.555 -15.882 29.678  1.00 16.74 ? 290 GLU D CB  1 
ATOM   3039 C CG  . GLU D 1 37  ? 61.384 -15.136 30.288  1.00 19.35 ? 290 GLU D CG  1 
ATOM   3040 C CD  . GLU D 1 37  ? 60.989 -13.862 29.562  1.00 20.65 ? 290 GLU D CD  1 
ATOM   3041 O OE1 . GLU D 1 37  ? 61.469 -13.629 28.454  1.00 20.89 ? 290 GLU D OE1 1 
ATOM   3042 O OE2 . GLU D 1 37  ? 60.199 -13.101 30.132  1.00 25.95 ? 290 GLU D OE2 1 
ATOM   3043 N N   . LEU D 1 38  ? 61.572 -18.810 29.161  1.00 13.88 ? 291 LEU D N   1 
ATOM   3044 C CA  . LEU D 1 38  ? 60.510 -19.786 29.013  1.00 13.80 ? 291 LEU D CA  1 
ATOM   3045 C C   . LEU D 1 38  ? 60.778 -21.002 29.892  1.00 13.79 ? 291 LEU D C   1 
ATOM   3046 O O   . LEU D 1 38  ? 59.858 -21.540 30.488  1.00 14.75 ? 291 LEU D O   1 
ATOM   3047 C CB  . LEU D 1 38  ? 60.351 -20.196 27.545  1.00 13.84 ? 291 LEU D CB  1 
ATOM   3048 C CG  . LEU D 1 38  ? 59.315 -21.301 27.318  1.00 14.76 ? 291 LEU D CG  1 
ATOM   3049 C CD1 . LEU D 1 38  ? 57.941 -20.904 27.871  1.00 15.60 ? 291 LEU D CD1 1 
ATOM   3050 C CD2 . LEU D 1 38  ? 59.235 -21.638 25.845  1.00 14.15 ? 291 LEU D CD2 1 
ATOM   3051 N N   . ILE D 1 39  ? 62.042 -21.432 29.981  1.00 13.72 ? 292 ILE D N   1 
ATOM   3052 C CA  . ILE D 1 39  ? 62.343 -22.593 30.803  1.00 14.07 ? 292 ILE D CA  1 
ATOM   3053 C C   . ILE D 1 39  ? 61.901 -22.350 32.241  1.00 14.42 ? 292 ILE D C   1 
ATOM   3054 O O   . ILE D 1 39  ? 61.352 -23.238 32.879  1.00 15.46 ? 292 ILE D O   1 
ATOM   3055 C CB  . ILE D 1 39  ? 63.830 -22.970 30.706  1.00 14.49 ? 292 ILE D CB  1 
ATOM   3056 C CG1 . ILE D 1 39  ? 64.136 -23.553 29.327  1.00 14.23 ? 292 ILE D CG1 1 
ATOM   3057 C CG2 . ILE D 1 39  ? 64.240 -23.922 31.822  1.00 15.63 ? 292 ILE D CG2 1 
ATOM   3058 C CD1 . ILE D 1 39  ? 65.609 -23.664 29.002  1.00 14.18 ? 292 ILE D CD1 1 
ATOM   3059 N N   . ARG D 1 40  ? 62.163 -21.149 32.767  1.00 16.13 ? 293 ARG D N   1 
ATOM   3060 C CA  . ARG D 1 40  ? 61.876 -20.944 34.178  1.00 18.06 ? 293 ARG D CA  1 
ATOM   3061 C C   . ARG D 1 40  ? 60.408 -20.614 34.411  1.00 16.32 ? 293 ARG D C   1 
ATOM   3062 O O   . ARG D 1 40  ? 59.955 -20.722 35.537  1.00 19.58 ? 293 ARG D O   1 
ATOM   3063 C CB  . ARG D 1 40  ? 62.839 -19.955 34.823  1.00 20.55 ? 293 ARG D CB  1 
ATOM   3064 C CG  . ARG D 1 40  ? 62.747 -18.566 34.239  1.00 20.93 ? 293 ARG D CG  1 
ATOM   3065 C CD  . ARG D 1 40  ? 63.740 -17.673 34.969  1.00 22.42 ? 293 ARG D CD  1 
ATOM   3066 N NE  . ARG D 1 40  ? 63.733 -16.344 34.384  1.00 20.76 ? 293 ARG D NE  1 
ATOM   3067 C CZ  . ARG D 1 40  ? 62.866 -15.389 34.672  1.00 22.34 ? 293 ARG D CZ  1 
ATOM   3068 N NH1 . ARG D 1 40  ? 61.973 -15.537 35.637  1.00 23.98 ? 293 ARG D NH1 1 
ATOM   3069 N NH2 . ARG D 1 40  ? 62.903 -14.264 33.980  1.00 22.78 ? 293 ARG D NH2 1 
ATOM   3070 N N   . GLN D 1 41  ? 59.647 -20.249 33.370  1.00 16.43 ? 294 GLN D N   1 
ATOM   3071 C CA  . GLN D 1 41  ? 58.280 -19.794 33.580  1.00 16.84 ? 294 GLN D CA  1 
ATOM   3072 C C   . GLN D 1 41  ? 57.221 -20.751 33.035  1.00 17.07 ? 294 GLN D C   1 
ATOM   3073 O O   . GLN D 1 41  ? 56.083 -20.713 33.495  1.00 16.68 ? 294 GLN D O   1 
ATOM   3074 C CB  . GLN D 1 41  ? 58.090 -18.412 32.970  1.00 17.59 ? 294 GLN D CB  1 
ATOM   3075 C CG  . GLN D 1 41  ? 58.943 -17.380 33.693  1.00 18.01 ? 294 GLN D CG  1 
ATOM   3076 C CD  . GLN D 1 41  ? 58.763 -16.003 33.133  1.00 20.54 ? 294 GLN D CD  1 
ATOM   3077 O OE1 . GLN D 1 41  ? 58.279 -15.815 32.025  1.00 20.83 ? 294 GLN D OE1 1 
ATOM   3078 N NE2 . GLN D 1 41  ? 59.151 -15.007 33.913  1.00 22.36 ? 294 GLN D NE2 1 
ATOM   3079 N N   . GLY D 1 42  ? 57.565 -21.577 32.041  1.00 15.77 ? 295 GLY D N   1 
ATOM   3080 C CA  . GLY D 1 42  ? 56.569 -22.441 31.425  1.00 15.14 ? 295 GLY D CA  1 
ATOM   3081 C C   . GLY D 1 42  ? 55.365 -21.655 30.917  1.00 15.25 ? 295 GLY D C   1 
ATOM   3082 O O   . GLY D 1 42  ? 55.516 -20.614 30.313  1.00 15.84 ? 295 GLY D O   1 
ATOM   3083 N N   . THR D 1 43  ? 54.163 -22.136 31.245  1.00 15.25 ? 296 THR D N   1 
ATOM   3084 C CA  . THR D 1 43  ? 52.930 -21.517 30.778  1.00 16.33 ? 296 THR D CA  1 
ATOM   3085 C C   . THR D 1 43  ? 52.658 -20.195 31.497  1.00 17.39 ? 296 THR D C   1 
ATOM   3086 O O   . THR D 1 43  ? 51.726 -19.507 31.090  1.00 18.65 ? 296 THR D O   1 
ATOM   3087 C CB  . THR D 1 43  ? 51.734 -22.465 30.944  1.00 16.49 ? 296 THR D CB  1 
ATOM   3088 O OG1 . THR D 1 43  ? 51.533 -22.728 32.341  1.00 18.42 ? 296 THR D OG1 1 
ATOM   3089 C CG2 . THR D 1 43  ? 51.936 -23.764 30.195  1.00 16.84 ? 296 THR D CG2 1 
ATOM   3090 N N   . ASP D 1 44  ? 53.466 -19.836 32.512  1.00 17.66 ? 297 ASP D N   1 
ATOM   3091 C CA  . ASP D 1 44  ? 53.373 -18.515 33.115  1.00 19.59 ? 297 ASP D CA  1 
ATOM   3092 C C   . ASP D 1 44  ? 54.131 -17.467 32.299  1.00 19.72 ? 297 ASP D C   1 
ATOM   3093 O O   . ASP D 1 44  ? 54.012 -16.271 32.556  1.00 21.29 ? 297 ASP D O   1 
ATOM   3094 C CB  . ASP D 1 44  ? 53.888 -18.519 34.557  1.00 20.59 ? 297 ASP D CB  1 
ATOM   3095 C CG  . ASP D 1 44  ? 53.076 -19.334 35.539  1.00 21.33 ? 297 ASP D CG  1 
ATOM   3096 O OD1 . ASP D 1 44  ? 53.682 -19.920 36.437  1.00 23.37 ? 297 ASP D OD1 1 
ATOM   3097 O OD2 . ASP D 1 44  ? 51.846 -19.380 35.408  1.00 23.60 ? 297 ASP D OD2 1 
ATOM   3098 N N   . TYR D 1 45  ? 54.901 -17.885 31.296  1.00 16.86 ? 298 TYR D N   1 
ATOM   3099 C CA  . TYR D 1 45  ? 55.571 -16.992 30.365  1.00 17.05 ? 298 TYR D CA  1 
ATOM   3100 C C   . TYR D 1 45  ? 54.538 -16.082 29.718  1.00 18.71 ? 298 TYR D C   1 
ATOM   3101 O O   . TYR D 1 45  ? 53.508 -16.544 29.260  1.00 17.17 ? 298 TYR D O   1 
ATOM   3102 C CB  . TYR D 1 45  ? 56.257 -17.850 29.305  1.00 17.23 ? 298 TYR D CB  1 
ATOM   3103 C CG  . TYR D 1 45  ? 57.068 -17.178 28.241  1.00 17.35 ? 298 TYR D CG  1 
ATOM   3104 C CD1 . TYR D 1 45  ? 56.735 -17.297 26.910  1.00 17.83 ? 298 TYR D CD1 1 
ATOM   3105 C CD2 . TYR D 1 45  ? 58.292 -16.616 28.532  1.00 19.95 ? 298 TYR D CD2 1 
ATOM   3106 C CE1 . TYR D 1 45  ? 57.528 -16.786 25.895  1.00 17.58 ? 298 TYR D CE1 1 
ATOM   3107 C CE2 . TYR D 1 45  ? 59.117 -16.132 27.530  1.00 19.78 ? 298 TYR D CE2 1 
ATOM   3108 C CZ  . TYR D 1 45  ? 58.747 -16.216 26.201  1.00 19.59 ? 298 TYR D CZ  1 
ATOM   3109 O OH  . TYR D 1 45  ? 59.546 -15.750 25.200  1.00 19.76 ? 298 TYR D OH  1 
ATOM   3110 N N   A LYS D 1 46  ? 54.817 -14.780 29.650  0.50 19.12 ? 299 LYS D N   1 
ATOM   3111 N N   B LYS D 1 46  ? 54.774 -14.773 29.733  0.50 19.31 ? 299 LYS D N   1 
ATOM   3112 C CA  A LYS D 1 46  ? 53.755 -13.846 29.298  0.50 20.27 ? 299 LYS D CA  1 
ATOM   3113 C CA  B LYS D 1 46  ? 53.718 -13.839 29.376  0.50 20.69 ? 299 LYS D CA  1 
ATOM   3114 C C   A LYS D 1 46  ? 53.431 -13.939 27.808  0.50 19.08 ? 299 LYS D C   1 
ATOM   3115 C C   B LYS D 1 46  ? 53.326 -14.013 27.911  0.50 19.04 ? 299 LYS D C   1 
ATOM   3116 O O   A LYS D 1 46  ? 52.322 -13.565 27.431  0.50 19.44 ? 299 LYS D O   1 
ATOM   3117 O O   B LYS D 1 46  ? 52.201 -13.686 27.534  0.50 19.23 ? 299 LYS D O   1 
ATOM   3118 C CB  A LYS D 1 46  ? 54.081 -12.436 29.803  0.50 21.89 ? 299 LYS D CB  1 
ATOM   3119 C CB  B LYS D 1 46  ? 54.150 -12.405 29.691  0.50 22.73 ? 299 LYS D CB  1 
ATOM   3120 C CG  A LYS D 1 46  ? 53.984 -12.278 31.313  0.50 24.07 ? 299 LYS D CG  1 
ATOM   3121 C CG  B LYS D 1 46  ? 54.202 -12.072 31.173  0.50 25.01 ? 299 LYS D CG  1 
ATOM   3122 C CD  A LYS D 1 46  ? 52.570 -12.229 31.848  0.50 26.61 ? 299 LYS D CD  1 
ATOM   3123 C CD  B LYS D 1 46  ? 52.887 -12.285 31.879  0.50 26.69 ? 299 LYS D CD  1 
ATOM   3124 C CE  A LYS D 1 46  ? 52.520 -12.088 33.357  0.50 27.73 ? 299 LYS D CE  1 
ATOM   3125 C CE  B LYS D 1 46  ? 52.954 -11.977 33.360  0.50 27.62 ? 299 LYS D CE  1 
ATOM   3126 N NZ  A LYS D 1 46  ? 53.440 -11.034 33.854  0.50 29.03 ? 299 LYS D NZ  1 
ATOM   3127 N NZ  B LYS D 1 46  ? 51.829 -12.600 34.097  0.50 28.44 ? 299 LYS D NZ  1 
ATOM   3128 N N   A HIS D 1 47  ? 54.336 -14.469 26.963  0.50 17.61 ? 300 HIS D N   1 
ATOM   3129 N N   B HIS D 1 47  ? 54.240 -14.562 27.101  0.50 17.62 ? 300 HIS D N   1 
ATOM   3130 C CA  A HIS D 1 47  ? 53.984 -14.672 25.563  0.50 16.90 ? 300 HIS D CA  1 
ATOM   3131 C CA  B HIS D 1 47  ? 54.036 -14.692 25.667  0.50 17.06 ? 300 HIS D CA  1 
ATOM   3132 C C   A HIS D 1 47  ? 53.669 -16.141 25.277  0.50 15.36 ? 300 HIS D C   1 
ATOM   3133 C C   B HIS D 1 47  ? 53.702 -16.136 25.306  0.50 15.37 ? 300 HIS D C   1 
ATOM   3134 O O   A HIS D 1 47  ? 53.654 -16.546 24.115  0.50 15.05 ? 300 HIS D O   1 
ATOM   3135 O O   B HIS D 1 47  ? 53.697 -16.503 24.139  0.50 15.01 ? 300 HIS D O   1 
ATOM   3136 C CB  A HIS D 1 47  ? 55.009 -14.078 24.587  0.50 17.88 ? 300 HIS D CB  1 
ATOM   3137 C CB  B HIS D 1 47  ? 55.270 -14.147 24.957  0.50 18.04 ? 300 HIS D CB  1 
ATOM   3138 C CG  A HIS D 1 47  ? 54.859 -12.598 24.398  0.50 18.38 ? 300 HIS D CG  1 
ATOM   3139 C CG  B HIS D 1 47  ? 55.410 -12.719 25.326  0.50 18.77 ? 300 HIS D CG  1 
ATOM   3140 N ND1 A HIS D 1 47  ? 54.176 -12.041 23.337  0.50 18.78 ? 300 HIS D ND1 1 
ATOM   3141 N ND1 B HIS D 1 47  ? 54.644 -11.767 24.694  0.50 20.27 ? 300 HIS D ND1 1 
ATOM   3142 C CD2 A HIS D 1 47  ? 55.284 -11.570 25.147  0.50 18.85 ? 300 HIS D CD2 1 
ATOM   3143 C CD2 B HIS D 1 47  ? 56.145 -12.079 26.241  0.50 20.13 ? 300 HIS D CD2 1 
ATOM   3144 C CE1 A HIS D 1 47  ? 54.208 -10.719 23.447  0.50 18.43 ? 300 HIS D CE1 1 
ATOM   3145 C CE1 B HIS D 1 47  ? 54.921 -10.583 25.219  0.50 19.31 ? 300 HIS D CE1 1 
ATOM   3146 N NE2 A HIS D 1 47  ? 54.860 -10.413 24.548  0.50 18.99 ? 300 HIS D NE2 1 
ATOM   3147 N NE2 B HIS D 1 47  ? 55.834 -10.749 26.157  0.50 20.32 ? 300 HIS D NE2 1 
ATOM   3148 N N   . TRP D 1 48  ? 53.359 -16.915 26.320  1.00 15.11 ? 301 TRP D N   1 
ATOM   3149 C CA  . TRP D 1 48  ? 53.017 -18.316 26.118  1.00 14.39 ? 301 TRP D CA  1 
ATOM   3150 C C   . TRP D 1 48  ? 51.898 -18.475 25.090  1.00 15.23 ? 301 TRP D C   1 
ATOM   3151 O O   . TRP D 1 48  ? 51.959 -19.377 24.258  1.00 14.41 ? 301 TRP D O   1 
ATOM   3152 C CB  . TRP D 1 48  ? 52.667 -18.998 27.433  1.00 15.14 ? 301 TRP D CB  1 
ATOM   3153 C CG  . TRP D 1 48  ? 52.265 -20.416 27.220  1.00 14.95 ? 301 TRP D CG  1 
ATOM   3154 C CD1 . TRP D 1 48  ? 51.017 -20.933 27.350  1.00 14.98 ? 301 TRP D CD1 1 
ATOM   3155 C CD2 . TRP D 1 48  ? 53.100 -21.479 26.732  1.00 14.16 ? 301 TRP D CD2 1 
ATOM   3156 N NE1 . TRP D 1 48  ? 51.024 -22.257 27.014  1.00 15.05 ? 301 TRP D NE1 1 
ATOM   3157 C CE2 . TRP D 1 48  ? 52.285 -22.621 26.624  1.00 14.48 ? 301 TRP D CE2 1 
ATOM   3158 C CE3 . TRP D 1 48  ? 54.457 -21.584 26.411  1.00 13.94 ? 301 TRP D CE3 1 
ATOM   3159 C CZ2 . TRP D 1 48  ? 52.780 -23.849 26.201  1.00 14.41 ? 301 TRP D CZ2 1 
ATOM   3160 C CZ3 . TRP D 1 48  ? 54.942 -22.809 26.011  1.00 13.73 ? 301 TRP D CZ3 1 
ATOM   3161 C CH2 . TRP D 1 48  ? 54.113 -23.919 25.901  1.00 15.50 ? 301 TRP D CH2 1 
ATOM   3162 N N   . PRO D 1 49  ? 50.819 -17.663 25.088  1.00 15.05 ? 302 PRO D N   1 
ATOM   3163 C CA  . PRO D 1 49  ? 49.738 -17.889 24.132  1.00 14.88 ? 302 PRO D CA  1 
ATOM   3164 C C   . PRO D 1 49  ? 50.201 -17.880 22.685  1.00 15.38 ? 302 PRO D C   1 
ATOM   3165 O O   . PRO D 1 49  ? 49.647 -18.584 21.854  1.00 15.89 ? 302 PRO D O   1 
ATOM   3166 C CB  . PRO D 1 49  ? 48.770 -16.737 24.415  1.00 16.00 ? 302 PRO D CB  1 
ATOM   3167 C CG  . PRO D 1 49  ? 48.985 -16.453 25.862  1.00 16.07 ? 302 PRO D CG  1 
ATOM   3168 C CD  . PRO D 1 49  ? 50.471 -16.634 26.082  1.00 15.69 ? 302 PRO D CD  1 
ATOM   3169 N N   . GLN D 1 50  ? 51.220 -17.081 22.361  1.00 14.29 ? 303 GLN D N   1 
ATOM   3170 C CA  . GLN D 1 50  ? 51.690 -16.989 20.992  1.00 13.84 ? 303 GLN D CA  1 
ATOM   3171 C C   . GLN D 1 50  ? 52.554 -18.191 20.597  1.00 14.04 ? 303 GLN D C   1 
ATOM   3172 O O   . GLN D 1 50  ? 52.773 -18.398 19.410  1.00 15.27 ? 303 GLN D O   1 
ATOM   3173 C CB  . GLN D 1 50  ? 52.402 -15.661 20.755  1.00 15.07 ? 303 GLN D CB  1 
ATOM   3174 C CG  . GLN D 1 50  ? 51.435 -14.475 20.642  1.00 16.99 ? 303 GLN D CG  1 
ATOM   3175 C CD  . GLN D 1 50  ? 50.800 -14.094 21.961  1.00 17.29 ? 303 GLN D CD  1 
ATOM   3176 O OE1 . GLN D 1 50  ? 51.459 -13.977 22.994  1.00 18.27 ? 303 GLN D OE1 1 
ATOM   3177 N NE2 . GLN D 1 50  ? 49.489 -13.934 21.967  1.00 17.55 ? 303 GLN D NE2 1 
ATOM   3178 N N   . ILE D 1 51  ? 53.021 -18.963 21.580  1.00 13.53 ? 304 ILE D N   1 
ATOM   3179 C CA  . ILE D 1 51  ? 53.637 -20.264 21.322  1.00 13.12 ? 304 ILE D CA  1 
ATOM   3180 C C   . ILE D 1 51  ? 52.548 -21.334 21.240  1.00 13.88 ? 304 ILE D C   1 
ATOM   3181 O O   . ILE D 1 51  ? 52.530 -22.141 20.299  1.00 13.71 ? 304 ILE D O   1 
ATOM   3182 C CB  . ILE D 1 51  ? 54.673 -20.579 22.414  1.00 13.70 ? 304 ILE D CB  1 
ATOM   3183 C CG1 . ILE D 1 51  ? 55.811 -19.549 22.387  1.00 15.11 ? 304 ILE D CG1 1 
ATOM   3184 C CG2 . ILE D 1 51  ? 55.166 -22.026 22.308  1.00 14.14 ? 304 ILE D CG2 1 
ATOM   3185 C CD1 . ILE D 1 51  ? 56.733 -19.614 23.577  1.00 15.25 ? 304 ILE D CD1 1 
ATOM   3186 N N   . ALA D 1 52  ? 51.649 -21.327 22.216  1.00 13.43 ? 305 ALA D N   1 
ATOM   3187 C CA  . ALA D 1 52  ? 50.632 -22.361 22.333  1.00 13.84 ? 305 ALA D CA  1 
ATOM   3188 C C   . ALA D 1 52  ? 49.710 -22.382 21.118  1.00 14.04 ? 305 ALA D C   1 
ATOM   3189 O O   . ALA D 1 52  ? 49.111 -23.427 20.861  1.00 14.38 ? 305 ALA D O   1 
ATOM   3190 C CB  . ALA D 1 52  ? 49.859 -22.186 23.611  1.00 14.36 ? 305 ALA D CB  1 
ATOM   3191 N N   . GLN D 1 53  ? 49.610 -21.289 20.356  1.00 13.94 ? 306 GLN D N   1 
ATOM   3192 C CA  . GLN D 1 53  ? 48.760 -21.273 19.176  1.00 13.76 ? 306 GLN D CA  1 
ATOM   3193 C C   . GLN D 1 53  ? 49.213 -22.321 18.167  1.00 13.48 ? 306 GLN D C   1 
ATOM   3194 O O   . GLN D 1 53  ? 48.442 -22.706 17.286  1.00 15.29 ? 306 GLN D O   1 
ATOM   3195 C CB  . GLN D 1 53  ? 48.754 -19.894 18.520  1.00 14.54 ? 306 GLN D CB  1 
ATOM   3196 C CG  . GLN D 1 53  ? 50.007 -19.545 17.746  1.00 15.66 ? 306 GLN D CG  1 
ATOM   3197 C CD  . GLN D 1 53  ? 49.916 -18.135 17.216  1.00 17.64 ? 306 GLN D CD  1 
ATOM   3198 O OE1 . GLN D 1 53  ? 48.971 -17.799 16.502  1.00 19.85 ? 306 GLN D OE1 1 
ATOM   3199 N NE2 . GLN D 1 53  ? 50.897 -17.312 17.555  1.00 18.14 ? 306 GLN D NE2 1 
ATOM   3200 N N   . PHE D 1 54  ? 50.454 -22.795 18.271  1.00 12.05 ? 307 PHE D N   1 
ATOM   3201 C CA  . PHE D 1 54  ? 50.981 -23.805 17.370  1.00 13.46 ? 307 PHE D CA  1 
ATOM   3202 C C   . PHE D 1 54  ? 50.835 -25.223 17.913  1.00 13.96 ? 307 PHE D C   1 
ATOM   3203 O O   . PHE D 1 54  ? 51.067 -26.171 17.167  1.00 15.86 ? 307 PHE D O   1 
ATOM   3204 C CB  . PHE D 1 54  ? 52.436 -23.494 17.025  1.00 13.76 ? 307 PHE D CB  1 
ATOM   3205 C CG  . PHE D 1 54  ? 52.551 -22.189 16.296  1.00 15.90 ? 307 PHE D CG  1 
ATOM   3206 C CD1 . PHE D 1 54  ? 52.007 -22.060 15.030  1.00 17.32 ? 307 PHE D CD1 1 
ATOM   3207 C CD2 . PHE D 1 54  ? 53.134 -21.080 16.886  1.00 16.32 ? 307 PHE D CD2 1 
ATOM   3208 C CE1 . PHE D 1 54  ? 52.082 -20.859 14.345  1.00 18.51 ? 307 PHE D CE1 1 
ATOM   3209 C CE2 . PHE D 1 54  ? 53.211 -19.879 16.195  1.00 17.22 ? 307 PHE D CE2 1 
ATOM   3210 C CZ  . PHE D 1 54  ? 52.641 -19.766 14.946  1.00 18.16 ? 307 PHE D CZ  1 
ATOM   3211 N N   . ALA D 1 55  ? 50.499 -25.391 19.189  1.00 13.57 ? 308 ALA D N   1 
ATOM   3212 C CA  . ALA D 1 55  ? 50.385 -26.727 19.746  1.00 13.12 ? 308 ALA D CA  1 
ATOM   3213 C C   . ALA D 1 55  ? 49.104 -27.388 19.255  1.00 13.43 ? 308 ALA D C   1 
ATOM   3214 O O   . ALA D 1 55  ? 48.066 -26.752 19.166  1.00 15.10 ? 308 ALA D O   1 
ATOM   3215 C CB  . ALA D 1 55  ? 50.408 -26.679 21.236  1.00 13.96 ? 308 ALA D CB  1 
ATOM   3216 N N   . PRO D 1 56  ? 49.149 -28.682 18.922  1.00 12.65 ? 309 PRO D N   1 
ATOM   3217 C CA  . PRO D 1 56  ? 47.959 -29.364 18.423  1.00 12.71 ? 309 PRO D CA  1 
ATOM   3218 C C   . PRO D 1 56  ? 46.985 -29.812 19.500  1.00 12.82 ? 309 PRO D C   1 
ATOM   3219 O O   . PRO D 1 56  ? 47.359 -30.210 20.595  1.00 13.78 ? 309 PRO D O   1 
ATOM   3220 C CB  . PRO D 1 56  ? 48.545 -30.595 17.728  1.00 12.56 ? 309 PRO D CB  1 
ATOM   3221 C CG  . PRO D 1 56  ? 49.793 -30.889 18.507  1.00 12.95 ? 309 PRO D CG  1 
ATOM   3222 C CD  . PRO D 1 56  ? 50.351 -29.524 18.862  1.00 13.04 ? 309 PRO D CD  1 
ATOM   3223 N N   . SER D 1 57  ? 45.707 -29.794 19.143  1.00 12.29 ? 310 SER D N   1 
ATOM   3224 C CA  . SER D 1 57  ? 44.703 -30.503 19.909  1.00 12.28 ? 310 SER D CA  1 
ATOM   3225 C C   . SER D 1 57  ? 45.029 -31.993 19.922  1.00 12.02 ? 310 SER D C   1 
ATOM   3226 O O   . SER D 1 57  ? 45.806 -32.468 19.101  1.00 11.88 ? 310 SER D O   1 
ATOM   3227 C CB  . SER D 1 57  ? 43.348 -30.285 19.294  1.00 12.98 ? 310 SER D CB  1 
ATOM   3228 O OG  . SER D 1 57  ? 43.274 -30.944 18.041  1.00 13.76 ? 310 SER D OG  1 
ATOM   3229 N N   . ALA D 1 58  ? 44.394 -32.749 20.823  1.00 12.24 ? 311 ALA D N   1 
ATOM   3230 C CA  . ALA D 1 58  ? 44.644 -34.179 20.845  1.00 12.77 ? 311 ALA D CA  1 
ATOM   3231 C C   . ALA D 1 58  ? 44.243 -34.810 19.517  1.00 12.42 ? 311 ALA D C   1 
ATOM   3232 O O   . ALA D 1 58  ? 44.917 -35.680 18.998  1.00 12.35 ? 311 ALA D O   1 
ATOM   3233 C CB  . ALA D 1 58  ? 43.916 -34.833 21.993  1.00 13.00 ? 311 ALA D CB  1 
ATOM   3234 N N   . SER D 1 59  ? 43.102 -34.382 18.978  1.00 12.36 ? 312 SER D N   1 
ATOM   3235 C CA  . SER D 1 59  ? 42.613 -34.875 17.706  1.00 12.67 ? 312 SER D CA  1 
ATOM   3236 C C   . SER D 1 59  ? 43.612 -34.571 16.594  1.00 12.21 ? 312 SER D C   1 
ATOM   3237 O O   . SER D 1 59  ? 43.938 -35.440 15.793  1.00 12.63 ? 312 SER D O   1 
ATOM   3238 C CB  . SER D 1 59  ? 41.256 -34.283 17.453  1.00 13.51 ? 312 SER D CB  1 
ATOM   3239 O OG  . SER D 1 59  ? 40.664 -34.792 16.278  1.00 14.27 ? 312 SER D OG  1 
ATOM   3240 N N   . ALA D 1 60  ? 44.132 -33.342 16.564  1.00 11.94 ? 313 ALA D N   1 
ATOM   3241 C CA  . ALA D 1 60  ? 45.094 -32.968 15.539  1.00 11.87 ? 313 ALA D CA  1 
ATOM   3242 C C   . ALA D 1 60  ? 46.414 -33.709 15.730  1.00 11.27 ? 313 ALA D C   1 
ATOM   3243 O O   . ALA D 1 60  ? 47.093 -34.054 14.767  1.00 12.00 ? 313 ALA D O   1 
ATOM   3244 C CB  . ALA D 1 60  ? 45.294 -31.477 15.526  1.00 12.10 ? 313 ALA D CB  1 
ATOM   3245 N N   . PHE D 1 61  ? 46.820 -33.912 16.980  1.00 11.47 ? 314 PHE D N   1 
ATOM   3246 C CA  . PHE D 1 61  ? 48.057 -34.625 17.219  1.00 11.64 ? 314 PHE D CA  1 
ATOM   3247 C C   . PHE D 1 61  ? 48.000 -36.012 16.587  1.00 11.54 ? 314 PHE D C   1 
ATOM   3248 O O   . PHE D 1 61  ? 48.918 -36.442 15.901  1.00 12.14 ? 314 PHE D O   1 
ATOM   3249 C CB  . PHE D 1 61  ? 48.318 -34.702 18.714  1.00 12.09 ? 314 PHE D CB  1 
ATOM   3250 C CG  . PHE D 1 61  ? 49.559 -35.460 19.082  1.00 11.94 ? 314 PHE D CG  1 
ATOM   3251 C CD1 . PHE D 1 61  ? 50.813 -34.874 18.949  1.00 12.61 ? 314 PHE D CD1 1 
ATOM   3252 C CD2 . PHE D 1 61  ? 49.457 -36.772 19.526  1.00 12.34 ? 314 PHE D CD2 1 
ATOM   3253 C CE1 . PHE D 1 61  ? 51.950 -35.600 19.282  1.00 13.91 ? 314 PHE D CE1 1 
ATOM   3254 C CE2 . PHE D 1 61  ? 50.593 -37.476 19.873  1.00 14.04 ? 314 PHE D CE2 1 
ATOM   3255 C CZ  . PHE D 1 61  ? 51.827 -36.875 19.767  1.00 13.73 ? 314 PHE D CZ  1 
ATOM   3256 N N   . PHE D 1 62  ? 46.910 -36.741 16.824  1.00 11.18 ? 315 PHE D N   1 
ATOM   3257 C CA  . PHE D 1 62  ? 46.757 -38.068 16.241  1.00 12.03 ? 315 PHE D CA  1 
ATOM   3258 C C   . PHE D 1 62  ? 46.294 -38.044 14.792  1.00 12.30 ? 315 PHE D C   1 
ATOM   3259 O O   . PHE D 1 62  ? 46.445 -39.052 14.120  1.00 12.54 ? 315 PHE D O   1 
ATOM   3260 C CB  . PHE D 1 62  ? 45.827 -38.924 17.098  1.00 11.50 ? 315 PHE D CB  1 
ATOM   3261 C CG  . PHE D 1 62  ? 46.555 -39.501 18.279  1.00 11.83 ? 315 PHE D CG  1 
ATOM   3262 C CD1 . PHE D 1 62  ? 46.463 -38.924 19.533  1.00 11.63 ? 315 PHE D CD1 1 
ATOM   3263 C CD2 . PHE D 1 62  ? 47.352 -40.613 18.106  1.00 11.90 ? 315 PHE D CD2 1 
ATOM   3264 C CE1 . PHE D 1 62  ? 47.194 -39.443 20.587  1.00 12.69 ? 315 PHE D CE1 1 
ATOM   3265 C CE2 . PHE D 1 62  ? 48.062 -41.132 19.170  1.00 12.76 ? 315 PHE D CE2 1 
ATOM   3266 C CZ  . PHE D 1 62  ? 47.984 -40.543 20.403  1.00 12.86 ? 315 PHE D CZ  1 
ATOM   3267 N N   . GLY D 1 63  ? 45.764 -36.913 14.321  1.00 12.62 ? 316 GLY D N   1 
ATOM   3268 C CA  . GLY D 1 63  ? 45.340 -36.805 12.933  1.00 12.80 ? 316 GLY D CA  1 
ATOM   3269 C C   . GLY D 1 63  ? 46.457 -36.400 11.973  1.00 12.96 ? 316 GLY D C   1 
ATOM   3270 O O   . GLY D 1 63  ? 46.512 -36.871 10.842  1.00 13.88 ? 316 GLY D O   1 
ATOM   3271 N N   A MET D 1 64  ? 47.357 -35.526 12.434  0.50 12.64 ? 317 MET D N   1 
ATOM   3272 N N   B MET D 1 64  ? 47.369 -35.548 12.440  0.50 12.69 ? 317 MET D N   1 
ATOM   3273 C CA  A MET D 1 64  ? 48.391 -34.974 11.578  0.50 13.12 ? 317 MET D CA  1 
ATOM   3274 C CA  B MET D 1 64  ? 48.392 -34.986 11.574  0.50 13.21 ? 317 MET D CA  1 
ATOM   3275 C C   A MET D 1 64  ? 49.688 -35.779 11.638  0.50 13.12 ? 317 MET D C   1 
ATOM   3276 C C   B MET D 1 64  ? 49.691 -35.785 11.635  0.50 13.17 ? 317 MET D C   1 
ATOM   3277 O O   A MET D 1 64  ? 50.458 -35.781 10.680  0.50 14.45 ? 317 MET D O   1 
ATOM   3278 O O   B MET D 1 64  ? 50.450 -35.811 10.669  0.50 14.48 ? 317 MET D O   1 
ATOM   3279 C CB  A MET D 1 64  ? 48.725 -33.551 12.014  0.50 14.09 ? 317 MET D CB  1 
ATOM   3280 C CB  B MET D 1 64  ? 48.714 -33.555 12.003  0.50 14.30 ? 317 MET D CB  1 
ATOM   3281 C CG  A MET D 1 64  ? 47.581 -32.591 11.854  0.50 14.83 ? 317 MET D CG  1 
ATOM   3282 C CG  B MET D 1 64  ? 47.567 -32.605 11.826  0.50 15.19 ? 317 MET D CG  1 
ATOM   3283 S SD  A MET D 1 64  ? 47.978 -30.919 12.431  0.50 16.76 ? 317 MET D SD  1 
ATOM   3284 S SD  B MET D 1 64  ? 47.960 -30.948 12.452  0.50 17.24 ? 317 MET D SD  1 
ATOM   3285 C CE  A MET D 1 64  ? 48.956 -31.268 13.892  0.50 15.43 ? 317 MET D CE  1 
ATOM   3286 C CE  B MET D 1 64  ? 49.081 -30.377 11.181  0.50 16.62 ? 317 MET D CE  1 
ATOM   3287 N N   . SER D 1 65  ? 49.986 -36.371 12.797  1.00 12.82 ? 318 SER D N   1 
ATOM   3288 C CA  . SER D 1 65  ? 51.315 -36.905 13.069  1.00 12.60 ? 318 SER D CA  1 
ATOM   3289 C C   . SER D 1 65  ? 51.528 -38.284 12.471  1.00 13.34 ? 318 SER D C   1 
ATOM   3290 O O   . SER D 1 65  ? 50.586 -39.057 12.211  1.00 13.23 ? 318 SER D O   1 
ATOM   3291 C CB  . SER D 1 65  ? 51.574 -36.997 14.543  1.00 13.14 ? 318 SER D CB  1 
ATOM   3292 O OG  . SER D 1 65  ? 51.361 -35.760 15.188  1.00 12.39 ? 318 SER D OG  1 
ATOM   3293 N N   . ARG D 1 66  ? 52.802 -38.619 12.279  1.00 13.48 ? 319 ARG D N   1 
ATOM   3294 C CA  . ARG D 1 66  ? 53.200 -39.981 12.016  1.00 13.75 ? 319 ARG D CA  1 
ATOM   3295 C C   . ARG D 1 66  ? 53.450 -40.634 13.362  1.00 12.58 ? 319 ARG D C   1 
ATOM   3296 O O   . ARG D 1 66  ? 54.354 -40.215 14.089  1.00 13.58 ? 319 ARG D O   1 
ATOM   3297 C CB  . ARG D 1 66  ? 54.434 -40.002 11.121  1.00 17.09 ? 319 ARG D CB  1 
ATOM   3298 C CG  . ARG D 1 66  ? 54.204 -39.209 9.842   1.00 20.54 ? 319 ARG D CG  1 
ATOM   3299 C CD  . ARG D 1 66  ? 55.086 -39.600 8.682   1.00 22.30 ? 319 ARG D CD  1 
ATOM   3300 N NE  . ARG D 1 66  ? 55.001 -41.019 8.421   1.00 21.90 ? 319 ARG D NE  1 
ATOM   3301 C CZ  . ARG D 1 66  ? 53.957 -41.656 7.898   1.00 19.97 ? 319 ARG D CZ  1 
ATOM   3302 N NH1 . ARG D 1 66  ? 53.942 -42.970 7.890   1.00 20.23 ? 319 ARG D NH1 1 
ATOM   3303 N NH2 . ARG D 1 66  ? 52.924 -40.974 7.420   1.00 22.39 ? 319 ARG D NH2 1 
ATOM   3304 N N   . ILE D 1 67  ? 52.640 -41.632 13.684  1.00 12.43 ? 320 ILE D N   1 
ATOM   3305 C CA  . ILE D 1 67  ? 52.637 -42.290 14.969  1.00 13.10 ? 320 ILE D CA  1 
ATOM   3306 C C   . ILE D 1 67  ? 53.276 -43.658 14.817  1.00 13.05 ? 320 ILE D C   1 
ATOM   3307 O O   . ILE D 1 67  ? 52.998 -44.369 13.848  1.00 14.09 ? 320 ILE D O   1 
ATOM   3308 C CB  . ILE D 1 67  ? 51.192 -42.419 15.487  1.00 13.20 ? 320 ILE D CB  1 
ATOM   3309 C CG1 . ILE D 1 67  ? 50.496 -41.067 15.633  1.00 12.67 ? 320 ILE D CG1 1 
ATOM   3310 C CG2 . ILE D 1 67  ? 51.157 -43.181 16.798  1.00 13.26 ? 320 ILE D CG2 1 
ATOM   3311 C CD1 . ILE D 1 67  ? 51.148 -40.118 16.642  1.00 13.35 ? 320 ILE D CD1 1 
ATOM   3312 N N   . GLY D 1 68  ? 54.072 -44.055 15.806  1.00 13.38 ? 321 GLY D N   1 
ATOM   3313 C CA  . GLY D 1 68  ? 54.588 -45.400 15.851  1.00 13.79 ? 321 GLY D CA  1 
ATOM   3314 C C   . GLY D 1 68  ? 54.669 -45.866 17.291  1.00 14.12 ? 321 GLY D C   1 
ATOM   3315 O O   . GLY D 1 68  ? 54.365 -45.129 18.216  1.00 13.74 ? 321 GLY D O   1 
ATOM   3316 N N   . MET D 1 69  ? 55.009 -47.143 17.443  1.00 14.90 ? 322 MET D N   1 
ATOM   3317 C CA  . MET D 1 69  ? 55.154 -47.739 18.754  1.00 16.12 ? 322 MET D CA  1 
ATOM   3318 C C   . MET D 1 69  ? 56.465 -48.508 18.764  1.00 17.86 ? 322 MET D C   1 
ATOM   3319 O O   . MET D 1 69  ? 56.762 -49.256 17.824  1.00 20.63 ? 322 MET D O   1 
ATOM   3320 C CB  . MET D 1 69  ? 54.004 -48.692 19.060  1.00 18.95 ? 322 MET D CB  1 
ATOM   3321 C CG  . MET D 1 69  ? 54.379 -49.614 20.212  1.00 22.85 ? 322 MET D CG  1 
ATOM   3322 S SD  . MET D 1 69  ? 53.096 -50.752 20.654  1.00 29.79 ? 322 MET D SD  1 
ATOM   3323 C CE  . MET D 1 69  ? 51.971 -49.528 21.281  1.00 17.86 ? 322 MET D CE  1 
ATOM   3324 N N   A GLU D 1 70  ? 57.262 -48.275 19.810  0.50 17.14 ? 323 GLU D N   1 
ATOM   3325 N N   B GLU D 1 70  ? 57.264 -48.263 19.805  0.50 16.98 ? 323 GLU D N   1 
ATOM   3326 C CA  A GLU D 1 70  ? 58.540 -48.942 19.971  0.50 18.36 ? 323 GLU D CA  1 
ATOM   3327 C CA  B GLU D 1 70  ? 58.546 -48.920 19.982  0.50 18.10 ? 323 GLU D CA  1 
ATOM   3328 C C   A GLU D 1 70  ? 58.575 -49.593 21.343  0.50 17.66 ? 323 GLU D C   1 
ATOM   3329 C C   B GLU D 1 70  ? 58.575 -49.590 21.347  0.50 17.52 ? 323 GLU D C   1 
ATOM   3330 O O   A GLU D 1 70  ? 58.244 -48.969 22.342  0.50 18.04 ? 323 GLU D O   1 
ATOM   3331 O O   B GLU D 1 70  ? 58.268 -48.971 22.360  0.50 17.92 ? 323 GLU D O   1 
ATOM   3332 C CB  A GLU D 1 70  ? 59.678 -47.938 19.855  0.50 20.09 ? 323 GLU D CB  1 
ATOM   3333 C CB  B GLU D 1 70  ? 59.683 -47.906 19.905  0.50 19.63 ? 323 GLU D CB  1 
ATOM   3334 C CG  A GLU D 1 70  ? 59.765 -47.253 18.506  0.50 22.50 ? 323 GLU D CG  1 
ATOM   3335 C CG  B GLU D 1 70  ? 59.897 -47.316 18.527  0.50 21.69 ? 323 GLU D CG  1 
ATOM   3336 C CD  A GLU D 1 70  ? 60.037 -48.166 17.322  0.50 24.10 ? 323 GLU D CD  1 
ATOM   3337 C CD  B GLU D 1 70  ? 61.223 -46.592 18.372  0.50 23.04 ? 323 GLU D CD  1 
ATOM   3338 O OE1 A GLU D 1 70  ? 59.766 -47.735 16.186  0.50 25.66 ? 323 GLU D OE1 1 
ATOM   3339 O OE1 B GLU D 1 70  ? 62.057 -46.697 19.292  0.50 24.13 ? 323 GLU D OE1 1 
ATOM   3340 O OE2 A GLU D 1 70  ? 60.506 -49.302 17.537  0.50 26.03 ? 323 GLU D OE2 1 
ATOM   3341 O OE2 B GLU D 1 70  ? 61.425 -45.934 17.334  0.50 24.79 ? 323 GLU D OE2 1 
ATOM   3342 N N   . VAL D 1 71  ? 58.959 -50.864 21.360  1.00 16.97 ? 324 VAL D N   1 
ATOM   3343 C CA  . VAL D 1 71  ? 59.094 -51.598 22.599  1.00 16.14 ? 324 VAL D CA  1 
ATOM   3344 C C   . VAL D 1 71  ? 60.584 -51.782 22.815  1.00 16.83 ? 324 VAL D C   1 
ATOM   3345 O O   . VAL D 1 71  ? 61.278 -52.343 21.957  1.00 18.15 ? 324 VAL D O   1 
ATOM   3346 C CB  . VAL D 1 71  ? 58.356 -52.941 22.541  1.00 18.47 ? 324 VAL D CB  1 
ATOM   3347 C CG1 . VAL D 1 71  ? 58.503 -53.684 23.854  1.00 19.34 ? 324 VAL D CG1 1 
ATOM   3348 C CG2 . VAL D 1 71  ? 56.886 -52.743 22.174  1.00 19.03 ? 324 VAL D CG2 1 
ATOM   3349 N N   . THR D 1 72  ? 61.063 -51.238 23.933  1.00 15.31 ? 325 THR D N   1 
ATOM   3350 C CA  . THR D 1 72  ? 62.496 -51.182 24.164  1.00 16.16 ? 325 THR D CA  1 
ATOM   3351 C C   . THR D 1 72  ? 62.740 -51.601 25.603  1.00 15.12 ? 325 THR D C   1 
ATOM   3352 O O   . THR D 1 72  ? 61.812 -51.773 26.372  1.00 15.74 ? 325 THR D O   1 
ATOM   3353 C CB  . THR D 1 72  ? 63.069 -49.782 23.893  1.00 17.00 ? 325 THR D CB  1 
ATOM   3354 O OG1 . THR D 1 72  ? 62.797 -48.993 25.045  1.00 16.62 ? 325 THR D OG1 1 
ATOM   3355 C CG2 . THR D 1 72  ? 62.499 -49.109 22.664  1.00 18.23 ? 325 THR D CG2 1 
ATOM   3356 N N   . PRO D 1 73  ? 64.009 -51.726 26.044  1.00 15.33 ? 326 PRO D N   1 
ATOM   3357 C CA  . PRO D 1 73  ? 64.265 -52.066 27.439  1.00 15.57 ? 326 PRO D CA  1 
ATOM   3358 C C   . PRO D 1 73  ? 63.698 -51.082 28.454  1.00 15.14 ? 326 PRO D C   1 
ATOM   3359 O O   . PRO D 1 73  ? 63.535 -51.431 29.604  1.00 17.62 ? 326 PRO D O   1 
ATOM   3360 C CB  . PRO D 1 73  ? 65.802 -52.150 27.465  1.00 16.51 ? 326 PRO D CB  1 
ATOM   3361 C CG  . PRO D 1 73  ? 66.182 -52.531 26.068  1.00 17.48 ? 326 PRO D CG  1 
ATOM   3362 C CD  . PRO D 1 73  ? 65.219 -51.738 25.210  1.00 16.64 ? 326 PRO D CD  1 
ATOM   3363 N N   . SER D 1 74  ? 63.420 -49.835 28.071  1.00 14.00 ? 327 SER D N   1 
ATOM   3364 C CA  . SER D 1 74  ? 62.875 -48.858 28.999  1.00 14.67 ? 327 SER D CA  1 
ATOM   3365 C C   . SER D 1 74  ? 61.354 -48.872 29.049  1.00 15.10 ? 327 SER D C   1 
ATOM   3366 O O   . SER D 1 74  ? 60.762 -48.244 29.918  1.00 17.29 ? 327 SER D O   1 
ATOM   3367 C CB  . SER D 1 74  ? 63.357 -47.486 28.668  1.00 15.25 ? 327 SER D CB  1 
ATOM   3368 O OG  . SER D 1 74  ? 62.965 -47.145 27.352  1.00 14.39 ? 327 SER D OG  1 
ATOM   3369 N N   . GLY D 1 75  ? 60.715 -49.540 28.088  1.00 14.21 ? 328 GLY D N   1 
ATOM   3370 C CA  . GLY D 1 75  ? 59.268 -49.586 28.092  1.00 14.60 ? 328 GLY D CA  1 
ATOM   3371 C C   . GLY D 1 75  ? 58.711 -49.555 26.677  1.00 13.44 ? 328 GLY D C   1 
ATOM   3372 O O   . GLY D 1 75  ? 59.401 -49.820 25.689  1.00 14.05 ? 328 GLY D O   1 
ATOM   3373 N N   . THR D 1 76  ? 57.432 -49.213 26.615  1.00 12.51 ? 329 THR D N   1 
ATOM   3374 C CA  . THR D 1 76  ? 56.722 -49.098 25.365  1.00 13.04 ? 329 THR D CA  1 
ATOM   3375 C C   . THR D 1 76  ? 56.468 -47.617 25.116  1.00 13.03 ? 329 THR D C   1 
ATOM   3376 O O   . THR D 1 76  ? 55.934 -46.940 25.976  1.00 13.62 ? 329 THR D O   1 
ATOM   3377 C CB  . THR D 1 76  ? 55.411 -49.875 25.448  1.00 13.25 ? 329 THR D CB  1 
ATOM   3378 O OG1 . THR D 1 76  ? 55.726 -51.241 25.697  1.00 14.47 ? 329 THR D OG1 1 
ATOM   3379 C CG2 . THR D 1 76  ? 54.616 -49.768 24.166  1.00 13.86 ? 329 THR D CG2 1 
ATOM   3380 N N   . TRP D 1 77  ? 56.863 -47.158 23.935  1.00 12.32 ? 330 TRP D N   1 
ATOM   3381 C CA  . TRP D 1 77  ? 56.890 -45.743 23.630  1.00 12.49 ? 330 TRP D CA  1 
ATOM   3382 C C   . TRP D 1 77  ? 56.064 -45.469 22.386  1.00 12.81 ? 330 TRP D C   1 
ATOM   3383 O O   . TRP D 1 77  ? 56.213 -46.150 21.381  1.00 13.99 ? 330 TRP D O   1 
ATOM   3384 C CB  . TRP D 1 77  ? 58.321 -45.275 23.379  1.00 13.02 ? 330 TRP D CB  1 
ATOM   3385 C CG  . TRP D 1 77  ? 59.223 -45.390 24.558  1.00 13.03 ? 330 TRP D CG  1 
ATOM   3386 C CD1 . TRP D 1 77  ? 59.831 -46.517 25.014  1.00 13.24 ? 330 TRP D CD1 1 
ATOM   3387 C CD2 . TRP D 1 77  ? 59.610 -44.308 25.417  1.00 12.77 ? 330 TRP D CD2 1 
ATOM   3388 N NE1 . TRP D 1 77  ? 60.569 -46.205 26.127  1.00 13.10 ? 330 TRP D NE1 1 
ATOM   3389 C CE2 . TRP D 1 77  ? 60.478 -44.863 26.381  1.00 12.69 ? 330 TRP D CE2 1 
ATOM   3390 C CE3 . TRP D 1 77  ? 59.316 -42.944 25.474  1.00 12.60 ? 330 TRP D CE3 1 
ATOM   3391 C CZ2 . TRP D 1 77  ? 61.082 -44.088 27.362  1.00 13.28 ? 330 TRP D CZ2 1 
ATOM   3392 C CZ3 . TRP D 1 77  ? 59.930 -42.175 26.436  1.00 13.46 ? 330 TRP D CZ3 1 
ATOM   3393 C CH2 . TRP D 1 77  ? 60.793 -42.748 27.369  1.00 13.38 ? 330 TRP D CH2 1 
ATOM   3394 N N   A LEU D 1 78  ? 55.226 -44.440 22.476  0.50 12.78 ? 331 LEU D N   1 
ATOM   3395 N N   B LEU D 1 78  ? 55.225 -44.444 22.470  0.50 12.48 ? 331 LEU D N   1 
ATOM   3396 C CA  A LEU D 1 78  ? 54.516 -43.920 21.327  0.50 13.73 ? 331 LEU D CA  1 
ATOM   3397 C CA  B LEU D 1 78  ? 54.522 -43.928 21.312  0.50 13.14 ? 331 LEU D CA  1 
ATOM   3398 C C   A LEU D 1 78  ? 55.382 -42.842 20.694  0.50 12.94 ? 331 LEU D C   1 
ATOM   3399 C C   B LEU D 1 78  ? 55.391 -42.843 20.692  0.50 12.67 ? 331 LEU D C   1 
ATOM   3400 O O   A LEU D 1 78  ? 55.630 -41.814 21.314  0.50 14.33 ? 331 LEU D O   1 
ATOM   3401 O O   B LEU D 1 78  ? 55.650 -41.816 21.314  0.50 14.16 ? 331 LEU D O   1 
ATOM   3402 C CB  A LEU D 1 78  ? 53.192 -43.328 21.803  0.50 14.77 ? 331 LEU D CB  1 
ATOM   3403 C CB  B LEU D 1 78  ? 53.175 -43.376 21.778  0.50 13.60 ? 331 LEU D CB  1 
ATOM   3404 C CG  A LEU D 1 78  ? 52.203 -43.017 20.693  0.50 16.72 ? 331 LEU D CG  1 
ATOM   3405 C CG  B LEU D 1 78  ? 52.237 -42.902 20.673  0.50 14.75 ? 331 LEU D CG  1 
ATOM   3406 C CD1 A LEU D 1 78  ? 51.652 -44.314 20.112  0.50 17.09 ? 331 LEU D CD1 1 
ATOM   3407 C CD1 B LEU D 1 78  ? 50.788 -43.116 21.091  0.50 15.27 ? 331 LEU D CD1 1 
ATOM   3408 C CD2 A LEU D 1 78  ? 51.073 -42.145 21.201  0.50 18.30 ? 331 LEU D CD2 1 
ATOM   3409 C CD2 B LEU D 1 78  ? 52.489 -41.445 20.349  0.50 15.48 ? 331 LEU D CD2 1 
ATOM   3410 N N   . THR D 1 79  ? 55.857 -43.084 19.473  1.00 12.17 ? 332 THR D N   1 
ATOM   3411 C CA  . THR D 1 79  ? 56.688 -42.117 18.778  1.00 12.24 ? 332 THR D CA  1 
ATOM   3412 C C   . THR D 1 79  ? 55.807 -41.240 17.899  1.00 11.91 ? 332 THR D C   1 
ATOM   3413 O O   . THR D 1 79  ? 54.752 -41.668 17.415  1.00 11.85 ? 332 THR D O   1 
ATOM   3414 C CB  . THR D 1 79  ? 57.748 -42.821 17.941  1.00 13.77 ? 332 THR D CB  1 
ATOM   3415 O OG1 . THR D 1 79  ? 57.072 -43.598 16.951  1.00 14.22 ? 332 THR D OG1 1 
ATOM   3416 C CG2 . THR D 1 79  ? 58.608 -43.727 18.788  1.00 14.64 ? 332 THR D CG2 1 
ATOM   3417 N N   . TYR D 1 80  ? 56.265 -40.009 17.681  1.00 11.36 ? 333 TYR D N   1 
ATOM   3418 C CA  . TYR D 1 80  ? 55.500 -39.094 16.858  1.00 11.66 ? 333 TYR D CA  1 
ATOM   3419 C C   . TYR D 1 80  ? 56.444 -38.178 16.100  1.00 12.66 ? 333 TYR D C   1 
ATOM   3420 O O   . TYR D 1 80  ? 57.483 -37.773 16.609  1.00 12.63 ? 333 TYR D O   1 
ATOM   3421 C CB  . TYR D 1 80  ? 54.508 -38.274 17.675  1.00 11.52 ? 333 TYR D CB  1 
ATOM   3422 C CG  . TYR D 1 80  ? 55.116 -37.397 18.733  1.00 11.37 ? 333 TYR D CG  1 
ATOM   3423 C CD1 . TYR D 1 80  ? 55.351 -37.872 20.005  1.00 11.53 ? 333 TYR D CD1 1 
ATOM   3424 C CD2 . TYR D 1 80  ? 55.471 -36.090 18.462  1.00 11.64 ? 333 TYR D CD2 1 
ATOM   3425 C CE1 . TYR D 1 80  ? 55.876 -37.064 20.994  1.00 12.06 ? 333 TYR D CE1 1 
ATOM   3426 C CE2 . TYR D 1 80  ? 55.995 -35.263 19.444  1.00 11.92 ? 333 TYR D CE2 1 
ATOM   3427 C CZ  . TYR D 1 80  ? 56.190 -35.748 20.721  1.00 11.90 ? 333 TYR D CZ  1 
ATOM   3428 O OH  . TYR D 1 80  ? 56.733 -34.961 21.717  1.00 12.93 ? 333 TYR D OH  1 
ATOM   3429 N N   A THR D 1 81  ? 56.075 -37.870 14.855  0.50 12.18 ? 334 THR D N   1 
ATOM   3430 N N   B THR D 1 81  ? 56.063 -37.856 14.864  0.50 12.38 ? 334 THR D N   1 
ATOM   3431 C CA  A THR D 1 81  ? 56.730 -36.834 14.085  0.50 12.39 ? 334 THR D CA  1 
ATOM   3432 C CA  B THR D 1 81  ? 56.742 -36.846 14.070  0.50 12.87 ? 334 THR D CA  1 
ATOM   3433 C C   A THR D 1 81  ? 55.663 -36.117 13.270  0.50 12.67 ? 334 THR D C   1 
ATOM   3434 C C   B THR D 1 81  ? 55.672 -36.120 13.271  0.50 12.88 ? 334 THR D C   1 
ATOM   3435 O O   A THR D 1 81  ? 54.649 -36.694 12.891  0.50 13.97 ? 334 THR D O   1 
ATOM   3436 O O   B THR D 1 81  ? 54.665 -36.714 12.904  0.50 14.09 ? 334 THR D O   1 
ATOM   3437 C CB  A THR D 1 81  ? 57.804 -37.380 13.139  0.50 13.42 ? 334 THR D CB  1 
ATOM   3438 C CB  B THR D 1 81  ? 57.786 -37.449 13.120  0.50 14.45 ? 334 THR D CB  1 
ATOM   3439 O OG1 A THR D 1 81  ? 57.159 -38.133 12.105  0.50 14.12 ? 334 THR D OG1 1 
ATOM   3440 O OG1 B THR D 1 81  ? 58.710 -38.257 13.843  0.50 16.95 ? 334 THR D OG1 1 
ATOM   3441 C CG2 A THR D 1 81  ? 58.869 -38.204 13.827  0.50 14.14 ? 334 THR D CG2 1 
ATOM   3442 C CG2 B THR D 1 81  ? 58.587 -36.408 12.376  0.50 14.91 ? 334 THR D CG2 1 
ATOM   3443 N N   . GLY D 1 82  ? 55.890 -34.844 12.983  1.00 11.52 ? 335 GLY D N   1 
ATOM   3444 C CA  . GLY D 1 82  ? 54.973 -34.138 12.115  1.00 11.49 ? 335 GLY D CA  1 
ATOM   3445 C C   . GLY D 1 82  ? 55.443 -32.719 11.890  1.00 12.07 ? 335 GLY D C   1 
ATOM   3446 O O   . GLY D 1 82  ? 56.555 -32.356 12.264  1.00 11.97 ? 335 GLY D O   1 
ATOM   3447 N N   . ALA D 1 83  ? 54.583 -31.943 11.273  1.00 12.47 ? 336 ALA D N   1 
ATOM   3448 C CA  . ALA D 1 83  ? 54.886 -30.560 10.993  1.00 14.02 ? 336 ALA D CA  1 
ATOM   3449 C C   . ALA D 1 83  ? 53.595 -29.773 10.933  1.00 15.19 ? 336 ALA D C   1 
ATOM   3450 O O   . ALA D 1 83  ? 52.595 -30.261 10.429  1.00 16.14 ? 336 ALA D O   1 
ATOM   3451 C CB  . ALA D 1 83  ? 55.674 -30.421 9.711   1.00 15.98 ? 336 ALA D CB  1 
ATOM   3452 N N   . ILE D 1 84  ? 53.672 -28.544 11.424  1.00 14.15 ? 337 ILE D N   1 
ATOM   3453 C CA  . ILE D 1 84  ? 52.550 -27.626 11.465  1.00 15.04 ? 337 ILE D CA  1 
ATOM   3454 C C   . ILE D 1 84  ? 52.900 -26.392 10.653  1.00 14.48 ? 337 ILE D C   1 
ATOM   3455 O O   . ILE D 1 84  ? 53.922 -25.747 10.874  1.00 13.84 ? 337 ILE D O   1 
ATOM   3456 C CB  . ILE D 1 84  ? 52.254 -27.287 12.928  1.00 16.24 ? 337 ILE D CB  1 
ATOM   3457 C CG1 . ILE D 1 84  ? 51.643 -28.530 13.582  1.00 17.57 ? 337 ILE D CG1 1 
ATOM   3458 C CG2 . ILE D 1 84  ? 51.363 -26.057 13.080  1.00 16.43 ? 337 ILE D CG2 1 
ATOM   3459 C CD1 . ILE D 1 84  ? 51.714 -28.556 15.067  1.00 18.85 ? 337 ILE D CD1 1 
ATOM   3460 N N   . LYS D 1 85  ? 52.013 -26.084 9.711   1.00 15.46 ? 338 LYS D N   1 
ATOM   3461 C CA  . LYS D 1 85  ? 52.289 -25.005 8.789   1.00 16.35 ? 338 LYS D CA  1 
ATOM   3462 C C   . LYS D 1 85  ? 51.954 -23.663 9.418   1.00 15.74 ? 338 LYS D C   1 
ATOM   3463 O O   . LYS D 1 85  ? 50.878 -23.466 9.965   1.00 17.31 ? 338 LYS D O   1 
ATOM   3464 C CB  . LYS D 1 85  ? 51.446 -25.191 7.533   1.00 18.81 ? 338 LYS D CB  1 
ATOM   3465 C CG  . LYS D 1 85  ? 51.897 -24.363 6.347   1.00 21.76 ? 338 LYS D CG  1 
ATOM   3466 C CD  . LYS D 1 85  ? 50.867 -24.415 5.245   1.00 27.24 ? 338 LYS D CD  1 
ATOM   3467 C CE  . LYS D 1 85  ? 51.480 -24.670 3.896   1.00 31.77 ? 338 LYS D CE  1 
ATOM   3468 N NZ  . LYS D 1 85  ? 50.438 -25.102 2.939   1.00 35.66 ? 338 LYS D NZ  1 
ATOM   3469 N N   . LEU D 1 86  ? 52.898 -22.726 9.328   1.00 14.51 ? 339 LEU D N   1 
ATOM   3470 C CA  . LEU D 1 86  ? 52.633 -21.350 9.713   1.00 15.20 ? 339 LEU D CA  1 
ATOM   3471 C C   . LEU D 1 86  ? 51.826 -20.709 8.593   1.00 15.63 ? 339 LEU D C   1 
ATOM   3472 O O   . LEU D 1 86  ? 51.960 -21.074 7.429   1.00 16.72 ? 339 LEU D O   1 
ATOM   3473 C CB  . LEU D 1 86  ? 53.939 -20.602 9.968   1.00 15.92 ? 339 LEU D CB  1 
ATOM   3474 C CG  . LEU D 1 86  ? 54.496 -20.690 11.382  1.00 18.18 ? 339 LEU D CG  1 
ATOM   3475 C CD1 . LEU D 1 86  ? 54.962 -22.094 11.692  1.00 18.85 ? 339 LEU D CD1 1 
ATOM   3476 C CD2 . LEU D 1 86  ? 55.648 -19.701 11.540  1.00 18.55 ? 339 LEU D CD2 1 
ATOM   3477 N N   . ASP D 1 87  ? 50.996 -19.739 8.957   1.00 16.79 ? 340 ASP D N   1 
ATOM   3478 C CA  . ASP D 1 87  ? 50.186 -19.030 7.980   1.00 18.45 ? 340 ASP D CA  1 
ATOM   3479 C C   . ASP D 1 87  ? 50.980 -17.826 7.493   1.00 19.19 ? 340 ASP D C   1 
ATOM   3480 O O   . ASP D 1 87  ? 51.051 -16.812 8.178   1.00 18.93 ? 340 ASP D O   1 
ATOM   3481 C CB  . ASP D 1 87  ? 48.847 -18.639 8.596   1.00 19.98 ? 340 ASP D CB  1 
ATOM   3482 C CG  . ASP D 1 87  ? 47.924 -17.895 7.643   1.00 22.54 ? 340 ASP D CG  1 
ATOM   3483 O OD1 . ASP D 1 87  ? 46.814 -17.537 8.096   1.00 26.96 ? 340 ASP D OD1 1 
ATOM   3484 O OD2 . ASP D 1 87  ? 48.331 -17.668 6.479   1.00 23.49 ? 340 ASP D OD2 1 
ATOM   3485 N N   A ASP D 1 88  ? 51.568 -17.954 6.291   0.50 21.03 ? 341 ASP D N   1 
ATOM   3486 N N   B ASP D 1 88  ? 51.604 -17.929 6.321   0.50 19.81 ? 341 ASP D N   1 
ATOM   3487 C CA  A ASP D 1 88  ? 52.463 -16.946 5.755   0.50 23.50 ? 341 ASP D CA  1 
ATOM   3488 C CA  B ASP D 1 88  ? 52.494 -16.868 5.883   0.50 21.43 ? 341 ASP D CA  1 
ATOM   3489 C C   A ASP D 1 88  ? 51.695 -15.680 5.369   0.50 24.01 ? 341 ASP D C   1 
ATOM   3490 C C   B ASP D 1 88  ? 51.702 -15.701 5.283   0.50 22.93 ? 341 ASP D C   1 
ATOM   3491 O O   A ASP D 1 88  ? 52.315 -14.642 5.141   0.50 25.58 ? 341 ASP D O   1 
ATOM   3492 O O   B ASP D 1 88  ? 52.314 -14.750 4.805   0.50 25.54 ? 341 ASP D O   1 
ATOM   3493 C CB  A ASP D 1 88  ? 53.263 -17.522 4.582   0.50 25.81 ? 341 ASP D CB  1 
ATOM   3494 C CB  B ASP D 1 88  ? 53.565 -17.421 4.941   0.50 21.82 ? 341 ASP D CB  1 
ATOM   3495 C CG  A ASP D 1 88  ? 52.443 -17.759 3.324   0.50 27.48 ? 341 ASP D CG  1 
ATOM   3496 C CG  B ASP D 1 88  ? 52.984 -18.214 3.787   0.50 22.23 ? 341 ASP D CG  1 
ATOM   3497 O OD1 A ASP D 1 88  ? 52.783 -17.156 2.295   0.50 28.39 ? 341 ASP D OD1 1 
ATOM   3498 O OD1 B ASP D 1 88  ? 51.978 -17.748 3.209   0.50 22.63 ? 341 ASP D OD1 1 
ATOM   3499 O OD2 A ASP D 1 88  ? 51.465 -18.534 3.387   0.50 30.81 ? 341 ASP D OD2 1 
ATOM   3500 O OD2 B ASP D 1 88  ? 53.550 -19.281 3.469   0.50 21.83 ? 341 ASP D OD2 1 
ATOM   3501 N N   . LYS D 1 89  ? 50.360 -15.769 5.329   1.00 24.04 ? 342 LYS D N   1 
ATOM   3502 C CA  . LYS D 1 89  ? 49.504 -14.635 4.997   1.00 26.80 ? 342 LYS D CA  1 
ATOM   3503 C C   . LYS D 1 89  ? 49.138 -13.831 6.242   1.00 25.67 ? 342 LYS D C   1 
ATOM   3504 O O   . LYS D 1 89  ? 48.642 -12.712 6.122   1.00 26.68 ? 342 LYS D O   1 
ATOM   3505 C CB  . LYS D 1 89  ? 48.204 -15.125 4.349   1.00 30.29 ? 342 LYS D CB  1 
ATOM   3506 C CG  . LYS D 1 89  ? 48.389 -15.890 3.047   1.00 35.01 ? 342 LYS D CG  1 
ATOM   3507 C CD  . LYS D 1 89  ? 49.115 -15.087 1.997   1.00 39.47 ? 342 LYS D CD  1 
ATOM   3508 C CE  . LYS D 1 89  ? 49.123 -15.766 0.645   1.00 43.56 ? 342 LYS D CE  1 
ATOM   3509 N NZ  . LYS D 1 89  ? 49.512 -14.819 -0.425  1.00 45.14 ? 342 LYS D NZ  1 
ATOM   3510 N N   . ASP D 1 90  ? 49.356 -14.408 7.431   1.00 22.82 ? 343 ASP D N   1 
ATOM   3511 C CA  . ASP D 1 90  ? 49.077 -13.731 8.687   1.00 21.74 ? 343 ASP D CA  1 
ATOM   3512 C C   . ASP D 1 90  ? 50.043 -12.558 8.796   1.00 20.53 ? 343 ASP D C   1 
ATOM   3513 O O   . ASP D 1 90  ? 51.246 -12.737 8.639   1.00 20.72 ? 343 ASP D O   1 
ATOM   3514 C CB  . ASP D 1 90  ? 49.209 -14.717 9.851   1.00 23.41 ? 343 ASP D CB  1 
ATOM   3515 C CG  . ASP D 1 90  ? 48.826 -14.192 11.225  1.00 24.08 ? 343 ASP D CG  1 
ATOM   3516 O OD1 . ASP D 1 90  ? 48.551 -15.030 12.113  1.00 25.18 ? 343 ASP D OD1 1 
ATOM   3517 O OD2 . ASP D 1 90  ? 48.844 -12.962 11.416  1.00 24.29 ? 343 ASP D OD2 1 
ATOM   3518 N N   . PRO D 1 91  ? 49.587 -11.307 9.039   1.00 20.06 ? 344 PRO D N   1 
ATOM   3519 C CA  . PRO D 1 91  ? 50.519 -10.197 9.200   1.00 20.62 ? 344 PRO D CA  1 
ATOM   3520 C C   . PRO D 1 91  ? 51.524 -10.425 10.327  1.00 18.93 ? 344 PRO D C   1 
ATOM   3521 O O   . PRO D 1 91  ? 52.600 -9.839  10.309  1.00 21.94 ? 344 PRO D O   1 
ATOM   3522 C CB  . PRO D 1 91  ? 49.653 -8.964  9.495   1.00 22.21 ? 344 PRO D CB  1 
ATOM   3523 C CG  . PRO D 1 91  ? 48.236 -9.477  9.626   1.00 24.28 ? 344 PRO D CG  1 
ATOM   3524 C CD  . PRO D 1 91  ? 48.180 -10.897 9.111   1.00 22.69 ? 344 PRO D CD  1 
ATOM   3525 N N   . ASN D 1 92  ? 51.174 -11.313 11.260  1.00 18.75 ? 345 ASN D N   1 
ATOM   3526 C CA  . ASN D 1 92  ? 52.026 -11.658 12.391  1.00 19.25 ? 345 ASN D CA  1 
ATOM   3527 C C   . ASN D 1 92  ? 53.018 -12.775 12.054  1.00 18.12 ? 345 ASN D C   1 
ATOM   3528 O O   . ASN D 1 92  ? 53.790 -13.164 12.917  1.00 18.22 ? 345 ASN D O   1 
ATOM   3529 C CB  . ASN D 1 92  ? 51.182 -12.086 13.592  1.00 20.69 ? 345 ASN D CB  1 
ATOM   3530 C CG  . ASN D 1 92  ? 50.230 -11.005 14.058  1.00 24.84 ? 345 ASN D CG  1 
ATOM   3531 O OD1 . ASN D 1 92  ? 50.670 -9.893  14.314  1.00 30.90 ? 345 ASN D OD1 1 
ATOM   3532 N ND2 . ASN D 1 92  ? 48.941 -11.297 14.120  1.00 26.83 ? 345 ASN D ND2 1 
ATOM   3533 N N   . PHE D 1 93  ? 53.057 -13.232 10.796  1.00 16.79 ? 346 PHE D N   1 
ATOM   3534 C CA  . PHE D 1 93  ? 53.902 -14.348 10.397  1.00 16.20 ? 346 PHE D CA  1 
ATOM   3535 C C   . PHE D 1 93  ? 55.364 -14.098 10.741  1.00 17.43 ? 346 PHE D C   1 
ATOM   3536 O O   . PHE D 1 93  ? 56.017 -14.974 11.309  1.00 17.85 ? 346 PHE D O   1 
ATOM   3537 C CB  . PHE D 1 93  ? 53.763 -14.611 8.899   1.00 16.95 ? 346 PHE D CB  1 
ATOM   3538 C CG  . PHE D 1 93  ? 54.751 -15.614 8.360   1.00 16.63 ? 346 PHE D CG  1 
ATOM   3539 C CD1 . PHE D 1 93  ? 55.819 -15.173 7.604   1.00 18.21 ? 346 PHE D CD1 1 
ATOM   3540 C CD2 . PHE D 1 93  ? 54.613 -16.972 8.593   1.00 18.75 ? 346 PHE D CD2 1 
ATOM   3541 C CE1 . PHE D 1 93  ? 56.725 -16.078 7.069   1.00 18.93 ? 346 PHE D CE1 1 
ATOM   3542 C CE2 . PHE D 1 93  ? 55.516 -17.874 8.062   1.00 19.19 ? 346 PHE D CE2 1 
ATOM   3543 C CZ  . PHE D 1 93  ? 56.571 -17.421 7.307   1.00 19.40 ? 346 PHE D CZ  1 
ATOM   3544 N N   . LYS D 1 94  ? 55.917 -12.940 10.372  1.00 16.84 ? 347 LYS D N   1 
ATOM   3545 C CA  . LYS D 1 94  ? 57.338 -12.734 10.587  1.00 18.70 ? 347 LYS D CA  1 
ATOM   3546 C C   . LYS D 1 94  ? 57.655 -12.777 12.078  1.00 18.07 ? 347 LYS D C   1 
ATOM   3547 O O   . LYS D 1 94  ? 58.692 -13.301 12.455  1.00 18.51 ? 347 LYS D O   1 
ATOM   3548 C CB  . LYS D 1 94  ? 57.794 -11.439 9.914   1.00 21.71 ? 347 LYS D CB  1 
ATOM   3549 C CG  . LYS D 1 94  ? 57.887 -11.580 8.400   1.00 26.24 ? 347 LYS D CG  1 
ATOM   3550 C CD  . LYS D 1 94  ? 58.674 -10.502 7.691   1.00 31.48 ? 347 LYS D CD  1 
ATOM   3551 C CE  . LYS D 1 94  ? 57.970 -9.166  7.682   1.00 35.51 ? 347 LYS D CE  1 
ATOM   3552 N NZ  . LYS D 1 94  ? 58.010 -8.518  9.011   1.00 38.18 ? 347 LYS D NZ  1 
ATOM   3553 N N   . ASP D 1 95  ? 56.762 -12.247 12.914  1.00 17.83 ? 348 ASP D N   1 
ATOM   3554 C CA  . ASP D 1 95  ? 56.943 -12.258 14.357  1.00 18.14 ? 348 ASP D CA  1 
ATOM   3555 C C   . ASP D 1 95  ? 56.838 -13.686 14.888  1.00 17.70 ? 348 ASP D C   1 
ATOM   3556 O O   . ASP D 1 95  ? 57.506 -14.045 15.858  1.00 17.29 ? 348 ASP D O   1 
ATOM   3557 C CB  . ASP D 1 95  ? 55.931 -11.354 15.067  1.00 21.50 ? 348 ASP D CB  1 
ATOM   3558 C CG  . ASP D 1 95  ? 56.161 -9.861  14.892  1.00 24.94 ? 348 ASP D CG  1 
ATOM   3559 O OD1 . ASP D 1 95  ? 57.275 -9.478  14.489  1.00 28.12 ? 348 ASP D OD1 1 
ATOM   3560 O OD2 . ASP D 1 95  ? 55.202 -9.094  15.147  1.00 29.49 ? 348 ASP D OD2 1 
ATOM   3561 N N   . GLN D 1 96  ? 55.981 -14.504 14.296  1.00 16.90 ? 349 GLN D N   1 
ATOM   3562 C CA  . GLN D 1 96  ? 55.841 -15.892 14.721  1.00 17.22 ? 349 GLN D CA  1 
ATOM   3563 C C   . GLN D 1 96  ? 57.128 -16.667 14.456  1.00 17.23 ? 349 GLN D C   1 
ATOM   3564 O O   . GLN D 1 96  ? 57.584 -17.444 15.299  1.00 16.89 ? 349 GLN D O   1 
ATOM   3565 C CB  . GLN D 1 96  ? 54.659 -16.523 14.006  1.00 16.86 ? 349 GLN D CB  1 
ATOM   3566 C CG  . GLN D 1 96  ? 53.344 -15.958 14.508  1.00 17.33 ? 349 GLN D CG  1 
ATOM   3567 C CD  . GLN D 1 96  ? 52.199 -16.253 13.579  1.00 18.53 ? 349 GLN D CD  1 
ATOM   3568 O OE1 . GLN D 1 96  ? 52.344 -16.957 12.583  1.00 20.02 ? 349 GLN D OE1 1 
ATOM   3569 N NE2 . GLN D 1 96  ? 51.030 -15.796 13.995  1.00 19.12 ? 349 GLN D NE2 1 
ATOM   3570 N N   . VAL D 1 97  ? 57.726 -16.445 13.287  1.00 16.01 ? 350 VAL D N   1 
ATOM   3571 C CA  . VAL D 1 97  ? 58.977 -17.092 12.953  1.00 16.42 ? 350 VAL D CA  1 
ATOM   3572 C C   . VAL D 1 97  ? 60.030 -16.691 13.979  1.00 17.22 ? 350 VAL D C   1 
ATOM   3573 O O   . VAL D 1 97  ? 60.772 -17.534 14.472  1.00 16.38 ? 350 VAL D O   1 
ATOM   3574 C CB  . VAL D 1 97  ? 59.411 -16.747 11.518  1.00 17.12 ? 350 VAL D CB  1 
ATOM   3575 C CG1 . VAL D 1 97  ? 60.815 -17.221 11.208  1.00 18.38 ? 350 VAL D CG1 1 
ATOM   3576 C CG2 . VAL D 1 97  ? 58.450 -17.321 10.495  1.00 16.75 ? 350 VAL D CG2 1 
ATOM   3577 N N   . ILE D 1 98  ? 60.097 -15.397 14.284  1.00 17.11 ? 351 ILE D N   1 
ATOM   3578 C CA  . ILE D 1 98  ? 61.095 -14.891 15.211  1.00 18.39 ? 351 ILE D CA  1 
ATOM   3579 C C   . ILE D 1 98  ? 60.874 -15.504 16.592  1.00 18.25 ? 351 ILE D C   1 
ATOM   3580 O O   . ILE D 1 98  ? 61.841 -15.897 17.243  1.00 18.63 ? 351 ILE D O   1 
ATOM   3581 C CB  . ILE D 1 98  ? 61.079 -13.350 15.252  1.00 19.78 ? 351 ILE D CB  1 
ATOM   3582 C CG1 . ILE D 1 98  ? 61.654 -12.787 13.952  1.00 20.82 ? 351 ILE D CG1 1 
ATOM   3583 C CG2 . ILE D 1 98  ? 61.842 -12.827 16.457  1.00 20.84 ? 351 ILE D CG2 1 
ATOM   3584 C CD1 . ILE D 1 98  ? 61.330 -11.322 13.711  1.00 22.80 ? 351 ILE D CD1 1 
ATOM   3585 N N   . LEU D 1 99  ? 59.635 -15.548 17.070  1.00 17.70 ? 352 LEU D N   1 
ATOM   3586 C CA  . LEU D 1 99  ? 59.392 -16.045 18.419  1.00 17.48 ? 352 LEU D CA  1 
ATOM   3587 C C   . LEU D 1 99  ? 59.777 -17.522 18.498  1.00 18.90 ? 352 LEU D C   1 
ATOM   3588 O O   . LEU D 1 99  ? 60.446 -17.960 19.463  1.00 20.57 ? 352 LEU D O   1 
ATOM   3589 C CB  . LEU D 1 99  ? 57.941 -15.803 18.829  1.00 18.87 ? 352 LEU D CB  1 
ATOM   3590 C CG  . LEU D 1 99  ? 57.481 -16.484 20.128  1.00 23.29 ? 352 LEU D CG  1 
ATOM   3591 C CD1 . LEU D 1 99  ? 58.259 -15.999 21.367  1.00 28.22 ? 352 LEU D CD1 1 
ATOM   3592 C CD2 . LEU D 1 99  ? 55.975 -16.317 20.293  1.00 24.87 ? 352 LEU D CD2 1 
ATOM   3593 N N   . LEU D 1 100 ? 59.396 -18.302 17.492  1.00 16.03 ? 353 LEU D N   1 
ATOM   3594 C CA  . LEU D 1 100 ? 59.710 -19.719 17.547  1.00 16.13 ? 353 LEU D CA  1 
ATOM   3595 C C   . LEU D 1 100 ? 61.224 -19.916 17.496  1.00 16.87 ? 353 LEU D C   1 
ATOM   3596 O O   . LEU D 1 100 ? 61.780 -20.712 18.258  1.00 16.84 ? 353 LEU D O   1 
ATOM   3597 C CB  . LEU D 1 100 ? 58.981 -20.438 16.410  1.00 16.74 ? 353 LEU D CB  1 
ATOM   3598 C CG  . LEU D 1 100 ? 57.468 -20.490 16.594  1.00 17.09 ? 353 LEU D CG  1 
ATOM   3599 C CD1 . LEU D 1 100 ? 56.769 -20.893 15.306  1.00 17.44 ? 353 LEU D CD1 1 
ATOM   3600 C CD2 . LEU D 1 100 ? 57.083 -21.425 17.738  1.00 17.03 ? 353 LEU D CD2 1 
ATOM   3601 N N   . ASN D 1 101 ? 61.909 -19.184 16.625  1.00 16.89 ? 354 ASN D N   1 
ATOM   3602 C CA  . ASN D 1 101 ? 63.351 -19.313 16.488  1.00 18.64 ? 354 ASN D CA  1 
ATOM   3603 C C   . ASN D 1 101 ? 64.078 -18.857 17.742  1.00 17.95 ? 354 ASN D C   1 
ATOM   3604 O O   . ASN D 1 101 ? 65.157 -19.378 18.019  1.00 19.33 ? 354 ASN D O   1 
ATOM   3605 C CB  . ASN D 1 101 ? 63.865 -18.606 15.237  1.00 19.41 ? 354 ASN D CB  1 
ATOM   3606 C CG  . ASN D 1 101 ? 63.589 -19.409 13.979  1.00 22.12 ? 354 ASN D CG  1 
ATOM   3607 O OD1 . ASN D 1 101 ? 63.420 -20.629 14.035  1.00 26.38 ? 354 ASN D OD1 1 
ATOM   3608 N ND2 . ASN D 1 101 ? 63.574 -18.757 12.833  1.00 24.96 ? 354 ASN D ND2 1 
ATOM   3609 N N   . LYS D 1 102 ? 63.487 -17.949 18.524  1.00 17.62 ? 355 LYS D N   1 
ATOM   3610 C CA  . LYS D 1 102 ? 64.085 -17.487 19.765  1.00 18.08 ? 355 LYS D CA  1 
ATOM   3611 C C   . LYS D 1 102 ? 64.223 -18.632 20.766  1.00 17.47 ? 355 LYS D C   1 
ATOM   3612 O O   . LYS D 1 102 ? 65.093 -18.596 21.640  1.00 17.82 ? 355 LYS D O   1 
ATOM   3613 C CB  . LYS D 1 102 ? 63.221 -16.393 20.397  1.00 21.53 ? 355 LYS D CB  1 
ATOM   3614 C CG  . LYS D 1 102 ? 63.783 -15.799 21.684  1.00 25.23 ? 355 LYS D CG  1 
ATOM   3615 C CD  . LYS D 1 102 ? 63.175 -14.495 22.077  1.00 28.59 ? 355 LYS D CD  1 
ATOM   3616 C CE  . LYS D 1 102 ? 61.817 -14.657 22.712  1.00 30.97 ? 355 LYS D CE  1 
ATOM   3617 N NZ  . LYS D 1 102 ? 61.342 -13.367 23.270  1.00 32.09 ? 355 LYS D NZ  1 
ATOM   3618 N N   . HIS D 1 103 ? 63.351 -19.640 20.663  1.00 14.68 ? 356 HIS D N   1 
ATOM   3619 C CA  . HIS D 1 103 ? 63.351 -20.745 21.607  1.00 13.65 ? 356 HIS D CA  1 
ATOM   3620 C C   . HIS D 1 103 ? 63.993 -22.013 21.050  1.00 13.48 ? 356 HIS D C   1 
ATOM   3621 O O   . HIS D 1 103 ? 64.464 -22.843 21.827  1.00 13.48 ? 356 HIS D O   1 
ATOM   3622 C CB  . HIS D 1 103 ? 61.931 -20.998 22.086  1.00 13.42 ? 356 HIS D CB  1 
ATOM   3623 C CG  . HIS D 1 103 ? 61.383 -19.857 22.849  1.00 13.18 ? 356 HIS D CG  1 
ATOM   3624 N ND1 . HIS D 1 103 ? 61.831 -19.565 24.116  1.00 13.79 ? 356 HIS D ND1 1 
ATOM   3625 C CD2 . HIS D 1 103 ? 60.487 -18.927 22.514  1.00 14.15 ? 356 HIS D CD2 1 
ATOM   3626 C CE1 . HIS D 1 103 ? 61.198 -18.476 24.539  1.00 13.53 ? 356 HIS D CE1 1 
ATOM   3627 N NE2 . HIS D 1 103 ? 60.353 -18.079 23.584  1.00 13.69 ? 356 HIS D NE2 1 
ATOM   3628 N N   . ILE D 1 104 ? 64.014 -22.195 19.738  1.00 12.49 ? 357 ILE D N   1 
ATOM   3629 C CA  . ILE D 1 104 ? 64.552 -23.411 19.168  1.00 12.46 ? 357 ILE D CA  1 
ATOM   3630 C C   . ILE D 1 104 ? 66.061 -23.436 19.385  1.00 13.36 ? 357 ILE D C   1 
ATOM   3631 O O   . ILE D 1 104 ? 66.779 -22.569 18.891  1.00 13.70 ? 357 ILE D O   1 
ATOM   3632 C CB  . ILE D 1 104 ? 64.212 -23.539 17.673  1.00 12.92 ? 357 ILE D CB  1 
ATOM   3633 C CG1 . ILE D 1 104 ? 62.716 -23.775 17.499  1.00 13.18 ? 357 ILE D CG1 1 
ATOM   3634 C CG2 . ILE D 1 104 ? 65.031 -24.640 17.006  1.00 13.10 ? 357 ILE D CG2 1 
ATOM   3635 C CD1 . ILE D 1 104 ? 62.226 -23.527 16.097  1.00 13.44 ? 357 ILE D CD1 1 
ATOM   3636 N N   . ASP D 1 105 ? 66.543 -24.455 20.098  1.00 13.08 ? 358 ASP D N   1 
ATOM   3637 C CA  . ASP D 1 105 ? 67.967 -24.626 20.362  1.00 13.94 ? 358 ASP D CA  1 
ATOM   3638 C C   . ASP D 1 105 ? 68.582 -23.446 21.110  1.00 13.88 ? 358 ASP D C   1 
ATOM   3639 O O   . ASP D 1 105 ? 69.809 -23.292 21.100  1.00 14.09 ? 358 ASP D O   1 
ATOM   3640 C CB  . ASP D 1 105 ? 68.758 -24.876 19.073  1.00 14.82 ? 358 ASP D CB  1 
ATOM   3641 C CG  . ASP D 1 105 ? 68.562 -26.263 18.496  1.00 15.23 ? 358 ASP D CG  1 
ATOM   3642 O OD1 . ASP D 1 105 ? 68.057 -27.136 19.207  1.00 14.79 ? 358 ASP D OD1 1 
ATOM   3643 O OD2 . ASP D 1 105 ? 68.904 -26.442 17.309  1.00 18.34 ? 358 ASP D OD2 1 
ATOM   3644 N N   . ALA D 1 106 ? 67.780 -22.679 21.844  1.00 13.31 ? 359 ALA D N   1 
ATOM   3645 C CA  . ALA D 1 106 ? 68.312 -21.564 22.612  1.00 13.35 ? 359 ALA D CA  1 
ATOM   3646 C C   . ALA D 1 106 ? 69.310 -22.069 23.646  1.00 13.28 ? 359 ALA D C   1 
ATOM   3647 O O   . ALA D 1 106 ? 70.248 -21.351 23.982  1.00 15.01 ? 359 ALA D O   1 
ATOM   3648 C CB  . ALA D 1 106 ? 67.187 -20.794 23.245  1.00 13.40 ? 359 ALA D CB  1 
ATOM   3649 N N   . TYR D 1 107 ? 69.099 -23.279 24.177  1.00 13.07 ? 360 TYR D N   1 
ATOM   3650 C CA  . TYR D 1 107 ? 69.941 -23.835 25.229  1.00 13.40 ? 360 TYR D CA  1 
ATOM   3651 C C   . TYR D 1 107 ? 71.415 -23.881 24.824  1.00 13.73 ? 360 TYR D C   1 
ATOM   3652 O O   . TYR D 1 107 ? 72.267 -23.970 25.701  1.00 14.33 ? 360 TYR D O   1 
ATOM   3653 C CB  . TYR D 1 107 ? 69.470 -25.251 25.603  1.00 13.69 ? 360 TYR D CB  1 
ATOM   3654 C CG  . TYR D 1 107 ? 69.889 -26.286 24.598  1.00 13.22 ? 360 TYR D CG  1 
ATOM   3655 C CD1 . TYR D 1 107 ? 71.130 -26.901 24.690  1.00 13.99 ? 360 TYR D CD1 1 
ATOM   3656 C CD2 . TYR D 1 107 ? 69.108 -26.558 23.484  1.00 12.79 ? 360 TYR D CD2 1 
ATOM   3657 C CE1 . TYR D 1 107 ? 71.595 -27.747 23.709  1.00 13.98 ? 360 TYR D CE1 1 
ATOM   3658 C CE2 . TYR D 1 107 ? 69.561 -27.407 22.491  1.00 13.18 ? 360 TYR D CE2 1 
ATOM   3659 C CZ  . TYR D 1 107 ? 70.805 -28.006 22.602  1.00 13.95 ? 360 TYR D CZ  1 
ATOM   3660 O OH  . TYR D 1 107 ? 71.298 -28.828 21.633  1.00 15.79 ? 360 TYR D OH  1 
ATOM   3661 N N   . LYS D 1 108 ? 71.736 -23.872 23.529  1.00 13.38 ? 361 LYS D N   1 
ATOM   3662 C CA  . LYS D 1 108 ? 73.128 -23.929 23.100  1.00 14.25 ? 361 LYS D CA  1 
ATOM   3663 C C   . LYS D 1 108 ? 73.927 -22.730 23.606  1.00 15.66 ? 361 LYS D C   1 
ATOM   3664 O O   . LYS D 1 108 ? 75.152 -22.825 23.693  1.00 16.80 ? 361 LYS D O   1 
ATOM   3665 C CB  . LYS D 1 108 ? 73.208 -23.950 21.578  1.00 14.75 ? 361 LYS D CB  1 
ATOM   3666 C CG  . LYS D 1 108 ? 72.700 -25.231 20.958  1.00 15.24 ? 361 LYS D CG  1 
ATOM   3667 C CD  . LYS D 1 108 ? 72.905 -25.265 19.468  1.00 17.79 ? 361 LYS D CD  1 
ATOM   3668 C CE  . LYS D 1 108 ? 72.434 -26.558 18.839  1.00 19.17 ? 361 LYS D CE  1 
ATOM   3669 N NZ  . LYS D 1 108 ? 72.745 -26.563 17.385  1.00 23.24 ? 361 LYS D NZ  1 
ATOM   3670 N N   . THR D 1 109 ? 73.244 -21.632 23.945  1.00 15.32 ? 362 THR D N   1 
ATOM   3671 C CA  . THR D 1 109 ? 73.905 -20.385 24.294  1.00 16.51 ? 362 THR D CA  1 
ATOM   3672 C C   . THR D 1 109 ? 74.058 -20.204 25.804  1.00 16.30 ? 362 THR D C   1 
ATOM   3673 O O   . THR D 1 109 ? 74.532 -19.159 26.241  1.00 16.61 ? 362 THR D O   1 
ATOM   3674 C CB  . THR D 1 109 ? 73.151 -19.192 23.688  1.00 17.77 ? 362 THR D CB  1 
ATOM   3675 O OG1 . THR D 1 109 ? 71.897 -19.020 24.343  1.00 19.86 ? 362 THR D OG1 1 
ATOM   3676 C CG2 . THR D 1 109 ? 72.936 -19.319 22.194  1.00 19.93 ? 362 THR D CG2 1 
ATOM   3677 N N   . PHE D 1 110 ? 73.593 -21.138 26.633  1.00 14.53 ? 363 PHE D N   1 
ATOM   3678 C CA  . PHE D 1 110 ? 73.733 -20.977 28.070  1.00 14.68 ? 363 PHE D CA  1 
ATOM   3679 C C   . PHE D 1 110 ? 73.991 -22.321 28.725  1.00 14.02 ? 363 PHE D C   1 
ATOM   3680 O O   . PHE D 1 110 ? 73.725 -23.361 28.128  1.00 14.76 ? 363 PHE D O   1 
ATOM   3681 C CB  . PHE D 1 110 ? 72.507 -20.291 28.665  1.00 15.10 ? 363 PHE D CB  1 
ATOM   3682 C CG  . PHE D 1 110 ? 71.168 -20.859 28.263  1.00 15.14 ? 363 PHE D CG  1 
ATOM   3683 C CD1 . PHE D 1 110 ? 70.438 -20.244 27.261  1.00 15.85 ? 363 PHE D CD1 1 
ATOM   3684 C CD2 . PHE D 1 110 ? 70.598 -21.919 28.935  1.00 15.37 ? 363 PHE D CD2 1 
ATOM   3685 C CE1 . PHE D 1 110 ? 69.167 -20.689 26.926  1.00 16.40 ? 363 PHE D CE1 1 
ATOM   3686 C CE2 . PHE D 1 110 ? 69.327 -22.378 28.582  1.00 15.12 ? 363 PHE D CE2 1 
ATOM   3687 C CZ  . PHE D 1 110 ? 68.615 -21.757 27.593  1.00 15.91 ? 363 PHE D CZ  1 
ATOM   3688 N N   . PRO D 1 111 ? 74.561 -22.375 29.945  1.00 14.72 ? 364 PRO D N   1 
ATOM   3689 C CA  . PRO D 1 111 ? 74.764 -23.660 30.606  1.00 15.11 ? 364 PRO D CA  1 
ATOM   3690 C C   . PRO D 1 111 ? 73.422 -24.384 30.805  1.00 16.46 ? 364 PRO D C   1 
ATOM   3691 O O   . PRO D 1 111 ? 72.495 -23.747 31.306  1.00 18.85 ? 364 PRO D O   1 
ATOM   3692 C CB  . PRO D 1 111 ? 75.432 -23.300 31.941  1.00 15.73 ? 364 PRO D CB  1 
ATOM   3693 C CG  . PRO D 1 111 ? 75.991 -21.930 31.750  1.00 15.55 ? 364 PRO D CG  1 
ATOM   3694 C CD  . PRO D 1 111 ? 75.108 -21.249 30.726  1.00 14.76 ? 364 PRO D CD  1 
ATOM   3695 O OXT . PRO D 1 111 ? 73.392 -25.558 30.465  1.00 16.77 ? 364 PRO D OXT 1 
HETATM 3696 C C4  . 657 E 2 .   ? 33.101 -27.687 9.440   0.80 25.21 ? 401 657 A C4  1 
HETATM 3697 N N2  . 657 E 2 .   ? 33.489 -28.675 13.045  0.80 27.46 ? 401 657 A N2  1 
HETATM 3698 C C7  . 657 E 2 .   ? 32.548 -25.569 5.691   0.80 30.02 ? 401 657 A C7  1 
HETATM 3699 C C6  . 657 E 2 .   ? 33.662 -26.895 7.269   0.80 26.78 ? 401 657 A C6  1 
HETATM 3700 C C8  . 657 E 2 .   ? 33.555 -28.234 11.785  0.80 26.33 ? 401 657 A C8  1 
HETATM 3701 C C1  . 657 E 2 .   ? 34.941 -26.572 7.709   0.80 27.32 ? 401 657 A C1  1 
HETATM 3702 C C2  . 657 E 2 .   ? 35.305 -26.806 9.027   0.80 25.97 ? 401 657 A C2  1 
HETATM 3703 C C3  . 657 E 2 .   ? 34.383 -27.376 9.904   0.80 24.89 ? 401 657 A C3  1 
HETATM 3704 C C5  . 657 E 2 .   ? 32.722 -27.452 8.126   0.80 26.10 ? 401 657 A C5  1 
HETATM 3705 O O1  . 657 E 2 .   ? 33.259 -26.672 5.932   0.80 29.10 ? 401 657 A O1  1 
HETATM 3706 F F1  . 657 E 2 .   ? 31.884 -25.642 4.554   0.80 31.11 ? 401 657 A F1  1 
HETATM 3707 F F2  . 657 E 2 .   ? 31.644 -25.305 6.619   0.80 26.82 ? 401 657 A F2  1 
HETATM 3708 F F3  . 657 E 2 .   ? 33.334 -24.523 5.621   0.80 31.28 ? 401 657 A F3  1 
HETATM 3709 S S1  . 657 E 2 .   ? 32.160 -28.395 10.729  0.80 24.47 ? 401 657 A S1  1 
HETATM 3710 N N1  . 657 E 2 .   ? 34.619 -27.697 11.243  0.80 25.90 ? 401 657 A N1  1 
HETATM 3711 S S   . SO4 F 3 .   ? 24.468 -23.261 -8.323  0.80 39.56 ? 402 SO4 A S   1 
HETATM 3712 O O1  . SO4 F 3 .   ? 25.686 -23.186 -9.084  0.80 43.20 ? 402 SO4 A O1  1 
HETATM 3713 O O2  . SO4 F 3 .   ? 24.514 -22.290 -7.265  0.80 38.45 ? 402 SO4 A O2  1 
HETATM 3714 O O3  . SO4 F 3 .   ? 23.348 -22.988 -9.181  0.80 44.74 ? 402 SO4 A O3  1 
HETATM 3715 O O4  . SO4 F 3 .   ? 24.328 -24.579 -7.762  0.80 41.85 ? 402 SO4 A O4  1 
HETATM 3716 S S   . SO4 G 3 .   ? 9.088  -33.351 24.967  0.50 30.85 ? 401 SO4 B S   1 
HETATM 3717 O O1  . SO4 G 3 .   ? 8.842  -34.258 23.884  0.50 30.54 ? 401 SO4 B O1  1 
HETATM 3718 O O2  . SO4 G 3 .   ? 10.023 -32.345 24.540  0.50 30.07 ? 401 SO4 B O2  1 
HETATM 3719 O O3  . SO4 G 3 .   ? 7.859  -32.718 25.356  0.50 32.16 ? 401 SO4 B O3  1 
HETATM 3720 O O4  . SO4 G 3 .   ? 9.628  -34.074 26.084  0.50 31.64 ? 401 SO4 B O4  1 
HETATM 3721 C C1  . EDO H 4 .   ? 61.513 -39.482 18.547  1.00 36.30 ? 401 EDO C C1  1 
HETATM 3722 O O1  . EDO H 4 .   ? 62.100 -38.455 17.769  1.00 38.55 ? 401 EDO C O1  1 
HETATM 3723 C C2  . EDO H 4 .   ? 60.667 -40.413 17.763  1.00 35.86 ? 401 EDO C C2  1 
HETATM 3724 O O2  . EDO H 4 .   ? 59.879 -39.769 16.782  1.00 36.18 ? 401 EDO C O2  1 
HETATM 3725 S S   . SO4 I 3 .   ? 59.910 -37.416 36.551  1.00 60.12 ? 401 SO4 D S   1 
HETATM 3726 O O1  . SO4 I 3 .   ? 58.999 -37.780 37.604  1.00 62.83 ? 401 SO4 D O1  1 
HETATM 3727 O O2  . SO4 I 3 .   ? 59.740 -36.024 36.222  1.00 57.70 ? 401 SO4 D O2  1 
HETATM 3728 O O3  . SO4 I 3 .   ? 61.263 -37.637 36.990  1.00 61.74 ? 401 SO4 D O3  1 
HETATM 3729 O O4  . SO4 I 3 .   ? 59.642 -38.223 35.388  1.00 60.54 ? 401 SO4 D O4  1 
HETATM 3730 O O   . HOH J 5 .   ? 25.561 -29.685 0.236   1.00 22.05 ? 501 HOH A O   1 
HETATM 3731 O O   . HOH J 5 .   ? 8.032  -41.344 -7.508  1.00 26.05 ? 502 HOH A O   1 
HETATM 3732 O O   . HOH J 5 .   ? 22.347 -35.470 -7.045  1.00 28.22 ? 503 HOH A O   1 
HETATM 3733 O O   . HOH J 5 .   ? 3.977  -39.350 5.511   1.00 35.88 ? 504 HOH A O   1 
HETATM 3734 O O   . HOH J 5 .   ? 12.753 -45.128 -4.618  1.00 26.71 ? 505 HOH A O   1 
HETATM 3735 O O   . HOH J 5 .   ? 31.609 -42.500 -1.707  1.00 42.19 ? 506 HOH A O   1 
HETATM 3736 O O   . HOH J 5 .   ? 10.203 -26.124 -0.470  1.00 26.87 ? 507 HOH A O   1 
HETATM 3737 O O   . HOH J 5 .   ? 29.930 -38.507 -6.393  1.00 35.40 ? 508 HOH A O   1 
HETATM 3738 O O   . HOH J 5 .   ? 35.616 -25.116 14.401  1.00 37.03 ? 509 HOH A O   1 
HETATM 3739 O O   . HOH J 5 .   ? 23.650 -27.080 -7.984  1.00 34.39 ? 510 HOH A O   1 
HETATM 3740 O O   . HOH J 5 .   ? 36.398 -21.426 13.137  1.00 33.98 ? 511 HOH A O   1 
HETATM 3741 O O   . HOH J 5 .   ? 13.532 -28.696 -16.480 1.00 41.87 ? 512 HOH A O   1 
HETATM 3742 O O   . HOH J 5 .   ? 6.575  -40.170 13.742  1.00 37.26 ? 513 HOH A O   1 
HETATM 3743 O O   . HOH J 5 .   ? 16.648 -47.512 -4.624  1.00 38.19 ? 514 HOH A O   1 
HETATM 3744 O O   . HOH J 5 .   ? 22.415 -31.015 18.239  1.00 35.41 ? 515 HOH A O   1 
HETATM 3745 O O   . HOH J 5 .   ? 28.752 -40.831 1.410   1.00 21.29 ? 516 HOH A O   1 
HETATM 3746 O O   . HOH J 5 .   ? 31.673 -25.185 12.900  1.00 22.59 ? 517 HOH A O   1 
HETATM 3747 O O   . HOH J 5 .   ? 34.487 -14.896 4.465   1.00 25.71 ? 518 HOH A O   1 
HETATM 3748 O O   . HOH J 5 .   ? 32.720 -30.562 -0.505  1.00 32.59 ? 519 HOH A O   1 
HETATM 3749 O O   . HOH J 5 .   ? 25.722 -45.833 4.502   1.00 33.55 ? 520 HOH A O   1 
HETATM 3750 O O   . HOH J 5 .   ? 9.397  -57.013 12.401  1.00 42.18 ? 521 HOH A O   1 
HETATM 3751 O O   . HOH J 5 .   ? 18.656 -47.759 -2.960  1.00 28.17 ? 522 HOH A O   1 
HETATM 3752 O O   . HOH J 5 .   ? 6.176  -39.243 16.235  1.00 38.97 ? 523 HOH A O   1 
HETATM 3753 O O   . HOH J 5 .   ? 11.446 -25.603 -7.612  1.00 32.71 ? 524 HOH A O   1 
HETATM 3754 O O   . HOH J 5 .   ? 9.190  -55.977 14.549  1.00 27.32 ? 525 HOH A O   1 
HETATM 3755 O O   . HOH J 5 .   ? 12.084 -22.890 -3.359  1.00 28.73 ? 526 HOH A O   1 
HETATM 3756 O O   . HOH J 5 .   ? 21.054 -24.266 -9.982  1.00 29.20 ? 527 HOH A O   1 
HETATM 3757 O O   . HOH J 5 .   ? 20.942 -36.314 -11.976 1.00 27.88 ? 528 HOH A O   1 
HETATM 3758 O O   . HOH J 5 .   ? 14.623 -34.762 -13.464 1.00 27.22 ? 529 HOH A O   1 
HETATM 3759 O O   . HOH J 5 .   ? 30.099 -27.916 -2.543  1.00 27.00 ? 530 HOH A O   1 
HETATM 3760 O O   . HOH J 5 .   ? 6.575  -38.010 11.912  1.00 24.28 ? 531 HOH A O   1 
HETATM 3761 O O   . HOH J 5 .   ? 4.468  -41.041 10.417  1.00 30.58 ? 532 HOH A O   1 
HETATM 3762 O O   . HOH J 5 .   ? 10.935 -26.503 -10.114 1.00 31.54 ? 533 HOH A O   1 
HETATM 3763 O O   . HOH J 5 .   ? 5.566  -34.751 5.444   1.00 25.34 ? 534 HOH A O   1 
HETATM 3764 O O   . HOH J 5 .   ? 12.828 -20.336 17.052  1.00 13.48 ? 535 HOH A O   1 
HETATM 3765 O O   . HOH J 5 .   ? 28.283 -32.512 -5.906  1.00 32.72 ? 536 HOH A O   1 
HETATM 3766 O O   . HOH J 5 .   ? 20.688 -24.792 18.742  1.00 11.73 ? 537 HOH A O   1 
HETATM 3767 O O   . HOH J 5 .   ? 36.768 -26.586 12.494  1.00 38.97 ? 538 HOH A O   1 
HETATM 3768 O O   . HOH J 5 .   ? 7.070  -35.312 11.559  1.00 20.02 ? 539 HOH A O   1 
HETATM 3769 O O   . HOH J 5 .   ? 5.487  -36.014 -3.794  1.00 39.62 ? 540 HOH A O   1 
HETATM 3770 O O   . HOH J 5 .   ? 12.189 -22.261 0.256   1.00 35.00 ? 541 HOH A O   1 
HETATM 3771 O O   . HOH J 5 .   ? 12.089 -52.083 8.732   1.00 22.86 ? 542 HOH A O   1 
HETATM 3772 O O   . HOH J 5 .   ? 22.693 -41.146 -2.548  1.00 15.34 ? 543 HOH A O   1 
HETATM 3773 O O   . HOH J 5 .   ? 29.854 -23.841 16.975  1.00 23.89 ? 544 HOH A O   1 
HETATM 3774 O O   . HOH J 5 .   ? 18.439 -39.913 -11.326 1.00 22.30 ? 545 HOH A O   1 
HETATM 3775 O O   . HOH J 5 .   ? 13.608 -44.440 18.181  1.00 19.41 ? 546 HOH A O   1 
HETATM 3776 O O   . HOH J 5 .   ? 10.796 -39.060 -13.321 1.00 26.22 ? 547 HOH A O   1 
HETATM 3777 O O   . HOH J 5 .   ? 33.280 -13.639 7.983   1.00 30.85 ? 548 HOH A O   1 
HETATM 3778 O O   . HOH J 5 .   ? 26.722 -39.420 -7.603  1.00 30.87 ? 549 HOH A O   1 
HETATM 3779 O O   . HOH J 5 .   ? 15.296 -31.657 -14.752 1.00 30.48 ? 550 HOH A O   1 
HETATM 3780 O O   . HOH J 5 .   ? 13.813 -28.514 6.550   1.00 17.27 ? 551 HOH A O   1 
HETATM 3781 O O   . HOH J 5 .   ? 21.100 -46.694 0.173   1.00 24.63 ? 552 HOH A O   1 
HETATM 3782 O O   . HOH J 5 .   ? 25.876 -32.479 -3.386  1.00 16.62 ? 553 HOH A O   1 
HETATM 3783 O O   . HOH J 5 .   ? 37.692 -22.276 9.735   1.00 27.86 ? 554 HOH A O   1 
HETATM 3784 O O   . HOH J 5 .   ? 5.862  -32.345 -2.596  1.00 34.24 ? 555 HOH A O   1 
HETATM 3785 O O   . HOH J 5 .   ? 9.280  -48.038 3.144   1.00 26.98 ? 556 HOH A O   1 
HETATM 3786 O O   . HOH J 5 .   ? 27.996 -27.059 13.470  1.00 14.52 ? 557 HOH A O   1 
HETATM 3787 O O   . HOH J 5 .   ? 33.917 -21.119 14.743  1.00 41.41 ? 558 HOH A O   1 
HETATM 3788 O O   . HOH J 5 .   ? 31.812 -47.044 1.336   1.00 39.47 ? 559 HOH A O   1 
HETATM 3789 O O   . HOH J 5 .   ? 25.756 -34.044 15.645  1.00 34.86 ? 560 HOH A O   1 
HETATM 3790 O O   . HOH J 5 .   ? 4.248  -46.361 5.921   1.00 34.56 ? 561 HOH A O   1 
HETATM 3791 O O   . HOH J 5 .   ? 7.658  -52.925 6.963   1.00 46.03 ? 562 HOH A O   1 
HETATM 3792 O O   . HOH J 5 .   ? 27.401 -42.067 -7.784  1.00 35.71 ? 563 HOH A O   1 
HETATM 3793 O O   . HOH J 5 .   ? 9.373  -41.375 13.350  1.00 24.41 ? 564 HOH A O   1 
HETATM 3794 O O   . HOH J 5 .   ? 29.600 -28.576 17.864  1.00 25.39 ? 565 HOH A O   1 
HETATM 3795 O O   . HOH J 5 .   ? 15.915 -50.266 2.470   1.00 25.30 ? 566 HOH A O   1 
HETATM 3796 O O   . HOH J 5 .   ? 9.166  -42.847 -10.875 1.00 40.01 ? 567 HOH A O   1 
HETATM 3797 O O   . HOH J 5 .   ? 17.587 -21.574 18.648  1.00 14.19 ? 568 HOH A O   1 
HETATM 3798 O O   . HOH J 5 .   ? 21.199 -46.120 6.241   1.00 24.59 ? 569 HOH A O   1 
HETATM 3799 O O   . HOH J 5 .   ? 6.617  -50.212 12.436  1.00 28.38 ? 570 HOH A O   1 
HETATM 3800 O O   . HOH J 5 .   ? 36.834 -16.193 3.551   1.00 29.25 ? 571 HOH A O   1 
HETATM 3801 O O   . HOH J 5 .   ? 17.173 -41.600 -13.068 1.00 32.58 ? 572 HOH A O   1 
HETATM 3802 O O   . HOH J 5 .   ? 30.649 -26.737 19.687  1.00 34.17 ? 573 HOH A O   1 
HETATM 3803 O O   . HOH J 5 .   ? 9.979  -23.583 8.876   1.00 22.10 ? 574 HOH A O   1 
HETATM 3804 O O   . HOH J 5 .   ? 18.492 -50.121 9.590   1.00 27.44 ? 575 HOH A O   1 
HETATM 3805 O O   . HOH J 5 .   ? 13.855 -23.848 -6.051  1.00 22.99 ? 576 HOH A O   1 
HETATM 3806 O O   . HOH J 5 .   ? 29.150 -31.877 6.342   1.00 31.53 ? 577 HOH A O   1 
HETATM 3807 O O   . HOH J 5 .   ? 27.952 -46.578 2.980   1.00 30.19 ? 578 HOH A O   1 
HETATM 3808 O O   . HOH J 5 .   ? 8.813  -30.324 0.894   1.00 22.48 ? 579 HOH A O   1 
HETATM 3809 O O   . HOH J 5 .   ? 15.081 -21.828 17.490  1.00 18.10 ? 580 HOH A O   1 
HETATM 3810 O O   . HOH J 5 .   ? 27.404 -31.526 -9.100  1.00 30.70 ? 581 HOH A O   1 
HETATM 3811 O O   . HOH J 5 .   ? 36.527 -19.495 11.205  1.00 27.63 ? 582 HOH A O   1 
HETATM 3812 O O   . HOH J 5 .   ? 14.473 -35.744 18.149  1.00 19.48 ? 583 HOH A O   1 
HETATM 3813 O O   . HOH J 5 .   ? 9.925  -22.384 12.197  1.00 17.65 ? 584 HOH A O   1 
HETATM 3814 O O   . HOH J 5 .   ? 23.499 -20.382 -2.262  1.00 26.00 ? 585 HOH A O   1 
HETATM 3815 O O   . HOH J 5 .   ? 20.589 -32.577 17.590  1.00 20.01 ? 586 HOH A O   1 
HETATM 3816 O O   . HOH J 5 .   ? 24.619 -36.371 14.733  1.00 28.27 ? 587 HOH A O   1 
HETATM 3817 O O   . HOH J 5 .   ? 25.154 -22.304 -3.905  1.00 31.17 ? 588 HOH A O   1 
HETATM 3818 O O   . HOH J 5 .   ? 31.222 -20.972 15.410  1.00 26.07 ? 589 HOH A O   1 
HETATM 3819 O O   . HOH J 5 .   ? 5.848  -42.630 7.582   1.00 24.38 ? 590 HOH A O   1 
HETATM 3820 O O   . HOH J 5 .   ? 6.069  -49.756 9.366   1.00 31.51 ? 591 HOH A O   1 
HETATM 3821 O O   . HOH J 5 .   ? 30.847 -29.787 13.704  1.00 28.37 ? 592 HOH A O   1 
HETATM 3822 O O   . HOH J 5 .   ? 35.451 -33.315 1.540   1.00 37.51 ? 593 HOH A O   1 
HETATM 3823 O O   . HOH J 5 .   ? 15.760 -45.357 -7.955  1.00 28.61 ? 594 HOH A O   1 
HETATM 3824 O O   . HOH J 5 .   ? 10.277 -38.248 14.470  1.00 22.91 ? 595 HOH A O   1 
HETATM 3825 O O   . HOH J 5 .   ? 35.392 -17.296 -3.049  1.00 29.22 ? 596 HOH A O   1 
HETATM 3826 O O   . HOH J 5 .   ? 24.347 -38.136 -8.014  1.00 30.52 ? 597 HOH A O   1 
HETATM 3827 O O   . HOH J 5 .   ? 18.857 -45.931 -7.513  1.00 28.45 ? 598 HOH A O   1 
HETATM 3828 O O   . HOH J 5 .   ? 37.013 -15.710 0.914   1.00 35.54 ? 599 HOH A O   1 
HETATM 3829 O O   . HOH J 5 .   ? 13.020 -17.928 5.476   1.00 29.04 ? 600 HOH A O   1 
HETATM 3830 O O   . HOH J 5 .   ? 14.284 -36.610 20.996  1.00 31.54 ? 601 HOH A O   1 
HETATM 3831 O O   . HOH J 5 .   ? 20.475 -34.092 -13.909 1.00 32.76 ? 602 HOH A O   1 
HETATM 3832 O O   . HOH J 5 .   ? 17.269 -21.869 -7.785  1.00 35.49 ? 603 HOH A O   1 
HETATM 3833 O O   . HOH J 5 .   ? 16.284 -51.628 4.923   1.00 33.41 ? 604 HOH A O   1 
HETATM 3834 O O   . HOH J 5 .   ? 8.199  -55.865 9.451   1.00 41.56 ? 605 HOH A O   1 
HETATM 3835 O O   . HOH J 5 .   ? 26.511 -34.387 -12.039 1.00 41.89 ? 606 HOH A O   1 
HETATM 3836 O O   . HOH J 5 .   ? 10.798 -28.402 6.470   1.00 31.27 ? 607 HOH A O   1 
HETATM 3837 O O   . HOH J 5 .   ? 2.685  -43.484 4.624   1.00 40.63 ? 608 HOH A O   1 
HETATM 3838 O O   . HOH J 5 .   ? 29.014 -34.915 -12.987 1.00 30.93 ? 609 HOH A O   1 
HETATM 3839 O O   . HOH J 5 .   ? 18.221 -37.193 -12.338 1.00 26.07 ? 610 HOH A O   1 
HETATM 3840 O O   . HOH J 5 .   ? 28.905 -29.401 11.922  1.00 19.22 ? 611 HOH A O   1 
HETATM 3841 O O   . HOH J 5 .   ? 10.952 -47.695 0.778   1.00 34.97 ? 612 HOH A O   1 
HETATM 3842 O O   . HOH J 5 .   ? 8.065  -27.448 9.536   1.00 36.24 ? 613 HOH A O   1 
HETATM 3843 O O   . HOH J 5 .   ? 20.626 -51.915 8.167   1.00 34.15 ? 614 HOH A O   1 
HETATM 3844 O O   . HOH J 5 .   ? 32.485 -31.410 -3.236  1.00 29.06 ? 615 HOH A O   1 
HETATM 3845 O O   . HOH J 5 .   ? 27.024 -22.602 -1.998  1.00 30.67 ? 616 HOH A O   1 
HETATM 3846 O O   . HOH J 5 .   ? 5.549  -52.418 9.087   1.00 40.32 ? 617 HOH A O   1 
HETATM 3847 O O   . HOH J 5 .   ? 19.072 -30.269 -18.659 1.00 34.32 ? 618 HOH A O   1 
HETATM 3848 O O   . HOH J 5 .   ? 16.665 -33.323 -16.469 1.00 34.94 ? 619 HOH A O   1 
HETATM 3849 O O   . HOH J 5 .   ? 17.711 -37.029 -14.871 1.00 27.50 ? 620 HOH A O   1 
HETATM 3850 O O   . HOH J 5 .   ? 12.269 -17.870 2.823   1.00 42.37 ? 621 HOH A O   1 
HETATM 3851 O O   . HOH J 5 .   ? 6.526  -44.695 6.012   1.00 29.88 ? 622 HOH A O   1 
HETATM 3852 O O   . HOH J 5 .   ? 34.283 -33.148 -5.182  1.00 40.19 ? 623 HOH A O   1 
HETATM 3853 O O   . HOH J 5 .   ? 8.854  -58.209 10.507  1.00 44.87 ? 624 HOH A O   1 
HETATM 3854 O O   . HOH J 5 .   ? 21.096 -48.549 -1.768  1.00 36.61 ? 625 HOH A O   1 
HETATM 3855 O O   . HOH J 5 .   ? 8.928  -37.936 16.987  1.00 31.66 ? 626 HOH A O   1 
HETATM 3856 O O   . HOH J 5 .   ? 5.597  -32.840 1.852   1.00 42.16 ? 627 HOH A O   1 
HETATM 3857 O O   . HOH J 5 .   ? 6.804  -30.109 -0.920  1.00 33.52 ? 628 HOH A O   1 
HETATM 3858 O O   . HOH J 5 .   ? 5.862  -40.971 -8.861  1.00 45.01 ? 629 HOH A O   1 
HETATM 3859 O O   . HOH J 5 .   ? 7.153  -44.691 3.065   1.00 40.59 ? 630 HOH A O   1 
HETATM 3860 O O   . HOH J 5 .   ? 7.589  -26.568 -1.110  1.00 38.27 ? 631 HOH A O   1 
HETATM 3861 O O   . HOH J 5 .   ? 9.872  -53.896 7.747   1.00 35.97 ? 632 HOH A O   1 
HETATM 3862 O O   . HOH J 5 .   ? 31.393 -25.659 15.595  1.00 27.37 ? 633 HOH A O   1 
HETATM 3863 O O   . HOH J 5 .   ? 29.622 -27.578 15.422  1.00 25.00 ? 634 HOH A O   1 
HETATM 3864 O O   . HOH J 5 .   ? 9.099  -25.299 -6.482  1.00 46.01 ? 635 HOH A O   1 
HETATM 3865 O O   . HOH J 5 .   ? 33.856 -16.064 -4.404  1.00 37.42 ? 636 HOH A O   1 
HETATM 3866 O O   . HOH J 5 .   ? 11.905 -19.651 0.582   1.00 46.75 ? 637 HOH A O   1 
HETATM 3867 O O   . HOH J 5 .   ? 14.968 -17.269 -1.440  1.00 47.52 ? 638 HOH A O   1 
HETATM 3868 O O   . HOH J 5 .   ? 4.759  -33.232 -0.569  1.00 48.51 ? 639 HOH A O   1 
HETATM 3869 O O   . HOH J 5 .   ? 9.949  -20.652 8.523   1.00 33.58 ? 640 HOH A O   1 
HETATM 3870 O O   . HOH J 5 .   ? 4.723  -34.225 10.831  1.00 37.30 ? 641 HOH A O   1 
HETATM 3871 O O   . HOH J 5 .   ? 2.086  -34.329 2.300   1.00 37.98 ? 642 HOH A O   1 
HETATM 3872 O O   . HOH J 5 .   ? 2.275  -34.021 -0.629  1.00 40.11 ? 643 HOH A O   1 
HETATM 3873 O O   . HOH K 5 .   ? 28.918 -34.172 24.503  1.00 22.56 ? 501 HOH B O   1 
HETATM 3874 O O   . HOH K 5 .   ? 19.208 -31.056 20.162  1.00 21.60 ? 502 HOH B O   1 
HETATM 3875 O O   . HOH K 5 .   ? 22.252 -3.257  3.773   1.00 33.33 ? 503 HOH B O   1 
HETATM 3876 O O   . HOH K 5 .   ? 3.417  -15.691 20.151  1.00 35.97 ? 504 HOH B O   1 
HETATM 3877 O O   . HOH K 5 .   ? 12.685 -9.523  19.713  1.00 24.46 ? 505 HOH B O   1 
HETATM 3878 O O   . HOH K 5 .   ? 27.005 -30.214 29.818  1.00 27.41 ? 506 HOH B O   1 
HETATM 3879 O O   . HOH K 5 .   ? 19.161 -9.158  17.318  1.00 29.14 ? 507 HOH B O   1 
HETATM 3880 O O   . HOH K 5 .   ? 18.640 -34.016 19.221  1.00 21.83 ? 508 HOH B O   1 
HETATM 3881 O O   . HOH K 5 .   ? 30.588 -18.093 16.233  1.00 33.02 ? 509 HOH B O   1 
HETATM 3882 O O   . HOH K 5 .   ? 17.409 -8.008  11.723  1.00 33.00 ? 510 HOH B O   1 
HETATM 3883 O O   . HOH K 5 .   ? 21.614 -23.058 28.927  1.00 17.54 ? 511 HOH B O   1 
HETATM 3884 O O   . HOH K 5 .   ? 5.012  -26.373 14.486  1.00 29.87 ? 512 HOH B O   1 
HETATM 3885 O O   . HOH K 5 .   ? 22.936 -11.149 22.872  1.00 24.13 ? 513 HOH B O   1 
HETATM 3886 O O   . HOH K 5 .   ? 20.022 -35.049 21.408  1.00 27.44 ? 514 HOH B O   1 
HETATM 3887 O O   . HOH K 5 .   ? 19.179 -10.677 20.503  1.00 18.86 ? 515 HOH B O   1 
HETATM 3888 O O   . HOH K 5 .   ? 5.388  -12.832 16.252  1.00 42.82 ? 516 HOH B O   1 
HETATM 3889 O O   . HOH K 5 .   ? 23.047 -7.307  17.471  1.00 29.22 ? 517 HOH B O   1 
HETATM 3890 O O   . HOH K 5 .   ? 22.314 -13.285 1.060   1.00 36.88 ? 518 HOH B O   1 
HETATM 3891 O O   . HOH K 5 .   ? 7.407  -23.372 11.778  1.00 27.19 ? 519 HOH B O   1 
HETATM 3892 O O   . HOH K 5 .   ? 4.815  -22.393 19.609  1.00 19.38 ? 520 HOH B O   1 
HETATM 3893 O O   . HOH K 5 .   ? 9.085  -17.479 26.662  1.00 14.78 ? 521 HOH B O   1 
HETATM 3894 O O   . HOH K 5 .   ? 12.747 -8.137  22.851  1.00 24.07 ? 522 HOH B O   1 
HETATM 3895 O O   . HOH K 5 .   ? 15.091 -20.784 29.062  1.00 24.26 ? 523 HOH B O   1 
HETATM 3896 O O   . HOH K 5 .   ? 13.526 -15.213 6.288   1.00 26.00 ? 524 HOH B O   1 
HETATM 3897 O O   . HOH K 5 .   ? 25.144 -12.536 22.367  1.00 28.90 ? 525 HOH B O   1 
HETATM 3898 O O   . HOH K 5 .   ? 21.856 -35.238 0.799   1.00 12.74 ? 526 HOH B O   1 
HETATM 3899 O O   . HOH K 5 .   ? 25.542 -41.667 6.398   1.00 27.92 ? 527 HOH B O   1 
HETATM 3900 O O   . HOH K 5 .   ? 23.847 -7.974  12.933  1.00 34.15 ? 528 HOH B O   1 
HETATM 3901 O O   . HOH K 5 .   ? 27.917 -10.933 17.084  1.00 28.41 ? 529 HOH B O   1 
HETATM 3902 O O   . HOH K 5 .   ? 15.203 -48.146 17.867  1.00 22.93 ? 530 HOH B O   1 
HETATM 3903 O O   . HOH K 5 .   ? 8.703  -10.509 20.203  1.00 33.60 ? 531 HOH B O   1 
HETATM 3904 O O   . HOH K 5 .   ? 23.300 -20.231 23.138  1.00 13.23 ? 532 HOH B O   1 
HETATM 3905 O O   . HOH K 5 .   ? 24.995 -25.598 1.208   1.00 31.91 ? 533 HOH B O   1 
HETATM 3906 O O   . HOH K 5 .   ? 28.900 -24.984 22.996  1.00 16.54 ? 534 HOH B O   1 
HETATM 3907 O O   . HOH K 5 .   ? 25.496 -41.040 11.417  1.00 30.09 ? 535 HOH B O   1 
HETATM 3908 O O   . HOH K 5 .   ? 31.060 -28.342 23.119  1.00 31.14 ? 536 HOH B O   1 
HETATM 3909 O O   . HOH K 5 .   ? 19.399 -15.091 2.179   1.00 31.79 ? 537 HOH B O   1 
HETATM 3910 O O   . HOH K 5 .   ? 30.088 -24.534 27.540  1.00 31.74 ? 538 HOH B O   1 
HETATM 3911 O O   . HOH K 5 .   ? 30.884 -16.397 2.034   1.00 20.96 ? 539 HOH B O   1 
HETATM 3912 O O   . HOH K 5 .   ? 16.614 -49.523 24.122  1.00 33.53 ? 540 HOH B O   1 
HETATM 3913 O O   . HOH K 5 .   ? 7.228  -30.069 25.179  1.00 24.55 ? 541 HOH B O   1 
HETATM 3914 O O   . HOH K 5 .   ? 30.789 -24.218 19.375  1.00 29.87 ? 542 HOH B O   1 
HETATM 3915 O O   . HOH K 5 .   ? 19.317 -29.580 26.800  1.00 38.94 ? 543 HOH B O   1 
HETATM 3916 O O   . HOH K 5 .   ? 5.496  -18.598 14.663  1.00 30.57 ? 544 HOH B O   1 
HETATM 3917 O O   . HOH K 5 .   ? 34.534 -14.769 -0.151  1.00 36.13 ? 545 HOH B O   1 
HETATM 3918 O O   . HOH K 5 .   ? 11.634 -30.225 25.158  1.00 30.42 ? 546 HOH B O   1 
HETATM 3919 O O   . HOH K 5 .   ? 17.667 -17.221 2.090   1.00 26.56 ? 547 HOH B O   1 
HETATM 3920 O O   . HOH K 5 .   ? 6.370  -27.597 11.424  1.00 28.61 ? 548 HOH B O   1 
HETATM 3921 O O   . HOH K 5 .   ? 12.114 -36.400 16.857  1.00 16.97 ? 549 HOH B O   1 
HETATM 3922 O O   . HOH K 5 .   ? 18.018 -22.736 26.708  1.00 19.65 ? 550 HOH B O   1 
HETATM 3923 O O   . HOH K 5 .   ? 21.227 -6.895  21.229  1.00 36.35 ? 551 HOH B O   1 
HETATM 3924 O O   . HOH K 5 .   ? 7.981  -15.690 12.820  1.00 27.84 ? 552 HOH B O   1 
HETATM 3925 O O   . HOH K 5 .   ? 13.712 -33.000 -2.748  1.00 16.65 ? 553 HOH B O   1 
HETATM 3926 O O   . HOH K 5 .   ? 19.795 -17.003 33.019  1.00 34.46 ? 554 HOH B O   1 
HETATM 3927 O O   . HOH K 5 .   ? 13.104 -8.521  11.136  1.00 23.24 ? 555 HOH B O   1 
HETATM 3928 O O   . HOH K 5 .   ? 23.950 -20.711 0.557   1.00 19.25 ? 556 HOH B O   1 
HETATM 3929 O O   . HOH K 5 .   ? 15.629 -6.146  21.658  1.00 28.66 ? 557 HOH B O   1 
HETATM 3930 O O   . HOH K 5 .   ? 30.385 -20.670 30.392  1.00 25.16 ? 558 HOH B O   1 
HETATM 3931 O O   . HOH K 5 .   ? 21.400 -5.800  7.460   1.00 39.16 ? 559 HOH B O   1 
HETATM 3932 O O   . HOH K 5 .   ? 15.776 -16.533 27.960  1.00 17.87 ? 560 HOH B O   1 
HETATM 3933 O O   . HOH K 5 .   ? 14.474 -25.429 8.289   1.00 17.71 ? 561 HOH B O   1 
HETATM 3934 O O   . HOH K 5 .   ? 17.262 -48.737 19.652  1.00 21.93 ? 562 HOH B O   1 
HETATM 3935 O O   . HOH K 5 .   ? 28.868 -16.772 -1.690  1.00 35.96 ? 563 HOH B O   1 
HETATM 3936 O O   . HOH K 5 .   ? 12.752 -28.827 27.463  1.00 30.06 ? 564 HOH B O   1 
HETATM 3937 O O   . HOH K 5 .   ? 29.821 -17.249 24.077  1.00 26.37 ? 565 HOH B O   1 
HETATM 3938 O O   . HOH K 5 .   ? 24.969 -12.515 28.949  1.00 36.93 ? 566 HOH B O   1 
HETATM 3939 O O   . HOH K 5 .   ? 27.393 -15.692 21.236  1.00 22.41 ? 567 HOH B O   1 
HETATM 3940 O O   . HOH K 5 .   ? 24.924 -37.650 9.196   1.00 16.79 ? 568 HOH B O   1 
HETATM 3941 O O   . HOH K 5 .   ? 8.517  -28.251 27.362  1.00 26.15 ? 569 HOH B O   1 
HETATM 3942 O O   . HOH K 5 .   ? 31.467 -19.907 19.843  1.00 37.29 ? 570 HOH B O   1 
HETATM 3943 O O   . HOH K 5 .   ? 17.985 -35.598 -1.475  1.00 16.33 ? 571 HOH B O   1 
HETATM 3944 O O   . HOH K 5 .   ? 23.943 -14.689 2.977   1.00 22.98 ? 572 HOH B O   1 
HETATM 3945 O O   . HOH K 5 .   ? 2.345  -19.036 20.425  1.00 32.44 ? 573 HOH B O   1 
HETATM 3946 O O   . HOH K 5 .   ? 19.072 -28.474 23.604  1.00 21.25 ? 574 HOH B O   1 
HETATM 3947 O O   . HOH K 5 .   ? 26.959 -31.703 3.213   1.00 25.15 ? 575 HOH B O   1 
HETATM 3948 O O   . HOH K 5 .   ? 7.376  -10.914 16.259  1.00 39.35 ? 576 HOH B O   1 
HETATM 3949 O O   . HOH K 5 .   ? 10.223 -27.045 3.494   1.00 21.60 ? 577 HOH B O   1 
HETATM 3950 O O   . HOH K 5 .   ? 24.336 -29.734 29.024  1.00 29.57 ? 578 HOH B O   1 
HETATM 3951 O O   . HOH K 5 .   ? 24.138 -44.080 8.464   1.00 28.16 ? 579 HOH B O   1 
HETATM 3952 O O   . HOH K 5 .   ? 23.463 -21.397 30.009  1.00 17.79 ? 580 HOH B O   1 
HETATM 3953 O O   . HOH K 5 .   ? 29.367 -29.001 9.122   1.00 22.94 ? 581 HOH B O   1 
HETATM 3954 O O   . HOH K 5 .   ? 26.078 -28.998 3.235   1.00 29.03 ? 582 HOH B O   1 
HETATM 3955 O O   . HOH K 5 .   ? 3.293  -17.099 22.154  1.00 29.62 ? 583 HOH B O   1 
HETATM 3956 O O   . HOH K 5 .   ? 29.500 -7.819  1.848   1.00 39.40 ? 584 HOH B O   1 
HETATM 3957 O O   . HOH K 5 .   ? 30.764 -9.298  10.339  1.00 29.83 ? 585 HOH B O   1 
HETATM 3958 O O   . HOH K 5 .   ? 5.068  -26.216 17.630  1.00 21.97 ? 586 HOH B O   1 
HETATM 3959 O O   . HOH K 5 .   ? 26.230 -5.812  6.623   1.00 35.95 ? 587 HOH B O   1 
HETATM 3960 O O   . HOH K 5 .   ? 10.033 -19.761 11.005  1.00 21.86 ? 588 HOH B O   1 
HETATM 3961 O O   . HOH K 5 .   ? 28.532 -6.557  4.452   1.00 25.70 ? 589 HOH B O   1 
HETATM 3962 O O   . HOH K 5 .   ? 21.647 -13.161 26.231  1.00 19.21 ? 590 HOH B O   1 
HETATM 3963 O O   . HOH K 5 .   ? 25.567 -22.983 0.409   1.00 19.43 ? 591 HOH B O   1 
HETATM 3964 O O   . HOH K 5 .   ? 10.296 -35.902 18.987  1.00 24.22 ? 592 HOH B O   1 
HETATM 3965 O O   . HOH K 5 .   ? 16.161 -33.422 -1.747  1.00 19.93 ? 593 HOH B O   1 
HETATM 3966 O O   . HOH K 5 .   ? 10.999 -28.579 0.389   1.00 19.41 ? 594 HOH B O   1 
HETATM 3967 O O   . HOH K 5 .   ? 23.289 -47.870 13.774  1.00 40.03 ? 595 HOH B O   1 
HETATM 3968 O O   . HOH K 5 .   ? 16.655 -29.220 28.729  1.00 28.82 ? 596 HOH B O   1 
HETATM 3969 O O   . HOH K 5 .   ? 17.098 -7.983  19.083  1.00 27.34 ? 597 HOH B O   1 
HETATM 3970 O O   . HOH K 5 .   ? 29.927 -17.209 18.781  1.00 30.53 ? 598 HOH B O   1 
HETATM 3971 O O   . HOH K 5 .   ? 8.066  -15.711 28.389  1.00 24.91 ? 599 HOH B O   1 
HETATM 3972 O O   . HOH K 5 .   ? 25.979 -17.945 -0.752  1.00 33.12 ? 600 HOH B O   1 
HETATM 3973 O O   . HOH K 5 .   ? 15.820 -31.655 25.105  1.00 38.39 ? 601 HOH B O   1 
HETATM 3974 O O   . HOH K 5 .   ? 20.030 -10.188 6.268   1.00 23.17 ? 602 HOH B O   1 
HETATM 3975 O O   . HOH K 5 .   ? 19.578 -11.547 24.713  1.00 23.85 ? 603 HOH B O   1 
HETATM 3976 O O   . HOH K 5 .   ? 6.708  -32.640 6.660   1.00 27.71 ? 604 HOH B O   1 
HETATM 3977 O O   . HOH K 5 .   ? 23.059 -17.773 1.984   1.00 30.95 ? 605 HOH B O   1 
HETATM 3978 O O   . HOH K 5 .   ? 18.333 -6.977  1.300   1.00 31.49 ? 606 HOH B O   1 
HETATM 3979 O O   . HOH K 5 .   ? 28.791 -38.243 6.671   1.00 40.52 ? 607 HOH B O   1 
HETATM 3980 O O   . HOH K 5 .   ? 14.156 -7.030  25.059  1.00 36.10 ? 608 HOH B O   1 
HETATM 3981 O O   . HOH K 5 .   ? 26.955 -36.922 10.490  1.00 33.39 ? 609 HOH B O   1 
HETATM 3982 O O   . HOH K 5 .   ? 33.181 -14.158 2.459   1.00 36.52 ? 610 HOH B O   1 
HETATM 3983 O O   . HOH K 5 .   ? 11.676 -35.473 21.180  1.00 37.41 ? 611 HOH B O   1 
HETATM 3984 O O   . HOH K 5 .   ? 13.857 -21.935 31.132  1.00 28.52 ? 612 HOH B O   1 
HETATM 3985 O O   . HOH K 5 .   ? 25.463 -5.791  13.275  1.00 35.90 ? 613 HOH B O   1 
HETATM 3986 O O   . HOH K 5 .   ? 13.524 -31.004 26.201  1.00 40.73 ? 614 HOH B O   1 
HETATM 3987 O O   . HOH K 5 .   ? 7.790  -30.747 5.374   1.00 46.33 ? 615 HOH B O   1 
HETATM 3988 O O   . HOH K 5 .   ? 28.782 -12.352 19.282  1.00 43.22 ? 616 HOH B O   1 
HETATM 3989 O O   . HOH K 5 .   ? 19.135 -32.381 23.099  1.00 35.45 ? 617 HOH B O   1 
HETATM 3990 O O   . HOH K 5 .   ? 31.088 -18.223 -3.762  1.00 37.10 ? 618 HOH B O   1 
HETATM 3991 O O   . HOH K 5 .   ? 30.525 -11.450 14.752  1.00 41.49 ? 619 HOH B O   1 
HETATM 3992 O O   . HOH K 5 .   ? 24.653 -38.098 16.683  1.00 32.77 ? 620 HOH B O   1 
HETATM 3993 O O   . HOH K 5 .   ? 5.394  -15.977 28.979  1.00 20.93 ? 621 HOH B O   1 
HETATM 3994 O O   . HOH K 5 .   ? 21.072 -4.540  11.204  1.00 40.87 ? 622 HOH B O   1 
HETATM 3995 O O   . HOH K 5 .   ? 12.257 -23.941 6.977   1.00 32.46 ? 623 HOH B O   1 
HETATM 3996 O O   . HOH K 5 .   ? 4.125  -13.539 29.805  1.00 29.62 ? 624 HOH B O   1 
HETATM 3997 O O   . HOH K 5 .   ? 31.471 -25.677 23.422  1.00 28.84 ? 625 HOH B O   1 
HETATM 3998 O O   . HOH K 5 .   ? 32.991 -14.553 -8.150  1.00 36.64 ? 626 HOH B O   1 
HETATM 3999 O O   . HOH K 5 .   ? 9.066  -7.999  23.618  1.00 41.68 ? 627 HOH B O   1 
HETATM 4000 O O   . HOH K 5 .   ? 3.068  -24.586 16.387  1.00 31.68 ? 628 HOH B O   1 
HETATM 4001 O O   . HOH K 5 .   ? 18.098 -20.536 28.925  1.00 33.53 ? 629 HOH B O   1 
HETATM 4002 O O   . HOH K 5 .   ? 13.761 -18.258 28.440  1.00 25.95 ? 630 HOH B O   1 
HETATM 4003 O O   . HOH K 5 .   ? 22.920 -8.676  15.274  1.00 29.95 ? 631 HOH B O   1 
HETATM 4004 O O   . HOH K 5 .   ? 33.949 -13.785 -5.849  1.00 32.35 ? 632 HOH B O   1 
HETATM 4005 O O   . HOH K 5 .   ? 18.685 -30.882 24.727  1.00 37.96 ? 633 HOH B O   1 
HETATM 4006 O O   . HOH K 5 .   ? 9.296  -8.191  20.955  1.00 38.39 ? 634 HOH B O   1 
HETATM 4007 O O   . HOH K 5 .   ? 7.858  -12.227 22.211  1.00 34.49 ? 635 HOH B O   1 
HETATM 4008 O O   . HOH K 5 .   ? 0.783  -25.994 17.331  1.00 28.36 ? 636 HOH B O   1 
HETATM 4009 O O   . HOH K 5 .   ? 1.166  -35.164 24.706  1.00 35.83 ? 637 HOH B O   1 
HETATM 4010 O O   . HOH K 5 .   ? 15.856 -15.039 30.532  1.00 31.37 ? 638 HOH B O   1 
HETATM 4011 O O   . HOH K 5 .   ? 11.746 -23.079 2.690   1.00 35.08 ? 639 HOH B O   1 
HETATM 4012 O O   . HOH K 5 .   ? 3.210  -22.063 17.372  1.00 26.49 ? 640 HOH B O   1 
HETATM 4013 O O   . HOH K 5 .   ? 10.687 -15.903 8.970   1.00 39.31 ? 641 HOH B O   1 
HETATM 4014 O O   . HOH K 5 .   ? 7.840  -18.180 11.513  1.00 33.64 ? 642 HOH B O   1 
HETATM 4015 O O   . HOH K 5 .   ? 17.711 -17.884 29.024  1.00 44.06 ? 643 HOH B O   1 
HETATM 4016 O O   . HOH K 5 .   ? 26.774 -37.312 13.076  1.00 32.37 ? 644 HOH B O   1 
HETATM 4017 O O   . HOH K 5 .   ? 32.367 -0.735  5.750   1.00 47.69 ? 645 HOH B O   1 
HETATM 4018 O O   . HOH K 5 .   ? 25.487 -7.544  18.380  1.00 42.66 ? 646 HOH B O   1 
HETATM 4019 O O   . HOH K 5 .   ? 26.965 -9.309  18.831  1.00 39.57 ? 647 HOH B O   1 
HETATM 4020 O O   . HOH K 5 .   ? 15.239 -16.333 2.041   1.00 45.30 ? 648 HOH B O   1 
HETATM 4021 O O   . HOH K 5 .   ? 22.796 -17.242 -0.718  1.00 32.57 ? 649 HOH B O   1 
HETATM 4022 O O   . HOH K 5 .   ? 31.385 -10.937 -9.722  1.00 32.61 ? 650 HOH B O   1 
HETATM 4023 O O   . HOH K 5 .   ? 28.524 -14.706 23.480  1.00 30.36 ? 651 HOH B O   1 
HETATM 4024 O O   . HOH K 5 .   ? 1.276  -16.180 24.302  1.00 41.31 ? 652 HOH B O   1 
HETATM 4025 O O   . HOH K 5 .   ? 26.457 -48.551 15.825  1.00 37.27 ? 653 HOH B O   1 
HETATM 4026 O O   . HOH K 5 .   ? 1.931  -17.403 18.229  1.00 35.66 ? 654 HOH B O   1 
HETATM 4027 O O   . HOH K 5 .   ? 10.954 -14.856 6.617   1.00 33.51 ? 655 HOH B O   1 
HETATM 4028 O O   . HOH K 5 .   ? 25.815 -37.806 19.066  1.00 36.56 ? 656 HOH B O   1 
HETATM 4029 O O   . HOH K 5 .   ? 4.901  -29.627 10.221  1.00 45.42 ? 657 HOH B O   1 
HETATM 4030 O O   . HOH K 5 .   ? 32.043 -7.916  4.033   1.00 36.97 ? 658 HOH B O   1 
HETATM 4031 O O   . HOH K 5 .   ? 12.665 -11.526 4.796   1.00 42.62 ? 659 HOH B O   1 
HETATM 4032 O O   . HOH K 5 .   ? 31.910 -10.251 12.685  1.00 34.88 ? 660 HOH B O   1 
HETATM 4033 O O   . HOH K 5 .   ? 3.686  -20.356 15.242  1.00 31.75 ? 661 HOH B O   1 
HETATM 4034 O O   . HOH K 5 .   ? 10.051 -24.676 1.832   1.00 37.24 ? 662 HOH B O   1 
HETATM 4035 O O   . HOH K 5 .   ? 31.678 -16.998 26.067  1.00 35.28 ? 663 HOH B O   1 
HETATM 4036 O O   . HOH K 5 .   ? 32.390 -10.746 8.354   1.00 35.62 ? 664 HOH B O   1 
HETATM 4037 O O   . HOH K 5 .   ? 10.494 -12.330 5.871   1.00 35.73 ? 665 HOH B O   1 
HETATM 4038 O O   . HOH L 5 .   ? 55.789 -48.129 32.382  1.00 38.62 ? 501 HOH C O   1 
HETATM 4039 O O   . HOH L 5 .   ? 33.372 -48.561 18.546  1.00 39.20 ? 502 HOH C O   1 
HETATM 4040 O O   . HOH L 5 .   ? 35.998 -39.062 23.139  1.00 27.61 ? 503 HOH C O   1 
HETATM 4041 O O   . HOH L 5 .   ? 51.216 -60.423 30.443  1.00 32.06 ? 504 HOH C O   1 
HETATM 4042 O O   . HOH L 5 .   ? 33.232 -35.909 20.455  1.00 33.68 ? 505 HOH C O   1 
HETATM 4043 O O   . HOH L 5 .   ? 57.776 -38.254 26.653  1.00 27.94 ? 506 HOH C O   1 
HETATM 4044 O O   . HOH L 5 .   ? 39.774 -30.739 20.775  1.00 29.19 ? 507 HOH C O   1 
HETATM 4045 O O   . HOH L 5 .   ? 32.016 -39.111 9.629   1.00 25.43 ? 508 HOH C O   1 
HETATM 4046 O O   . HOH L 5 .   ? 44.001 -57.057 26.681  1.00 32.21 ? 509 HOH C O   1 
HETATM 4047 O O   . HOH L 5 .   ? 40.858 -51.264 28.688  1.00 23.03 ? 510 HOH C O   1 
HETATM 4048 O O   . HOH L 5 .   ? 38.092 -49.584 15.658  1.00 25.35 ? 511 HOH C O   1 
HETATM 4049 O O   . HOH L 5 .   ? 49.614 -53.494 33.292  1.00 29.73 ? 512 HOH C O   1 
HETATM 4050 O O   . HOH L 5 .   ? 47.819 -44.847 30.881  1.00 20.55 ? 513 HOH C O   1 
HETATM 4051 O O   . HOH L 5 .   ? 59.877 -18.538 5.531   1.00 35.99 ? 514 HOH C O   1 
HETATM 4052 O O   . HOH L 5 .   ? 38.263 -28.134 6.431   1.00 34.50 ? 515 HOH C O   1 
HETATM 4053 O O   . HOH L 5 .   ? 50.951 -23.824 0.649   1.00 37.34 ? 516 HOH C O   1 
HETATM 4054 O O   . HOH L 5 .   ? 33.950 -45.640 7.098   1.00 37.52 ? 517 HOH C O   1 
HETATM 4055 O O   . HOH L 5 .   ? 56.428 -44.142 5.260   1.00 42.06 ? 518 HOH C O   1 
HETATM 4056 O O   . HOH L 5 .   ? 52.759 -45.253 6.849   1.00 22.80 ? 519 HOH C O   1 
HETATM 4057 O O   . HOH L 5 .   ? 32.920 -45.910 18.396  1.00 20.23 ? 520 HOH C O   1 
HETATM 4058 O O   . HOH L 5 .   ? 40.443 -51.903 12.446  1.00 34.82 ? 521 HOH C O   1 
HETATM 4059 O O   . HOH L 5 .   ? 68.047 -31.047 16.245  1.00 39.18 ? 522 HOH C O   1 
HETATM 4060 O O   . HOH L 5 .   ? 56.482 -19.649 3.883   1.00 20.72 ? 523 HOH C O   1 
HETATM 4061 O O   . HOH L 5 .   ? 42.219 -49.437 26.820  1.00 21.01 ? 524 HOH C O   1 
HETATM 4062 O O   . HOH L 5 .   ? 47.066 -51.206 12.090  1.00 20.45 ? 525 HOH C O   1 
HETATM 4063 O O   . HOH L 5 .   ? 63.260 -29.680 11.339  1.00 22.12 ? 526 HOH C O   1 
HETATM 4064 O O   . HOH L 5 .   ? 43.094 -52.109 11.914  1.00 25.46 ? 527 HOH C O   1 
HETATM 4065 O O   . HOH L 5 .   ? 43.788 -46.106 31.551  1.00 17.65 ? 528 HOH C O   1 
HETATM 4066 O O   . HOH L 5 .   ? 47.299 -43.744 1.608   1.00 36.91 ? 529 HOH C O   1 
HETATM 4067 O O   . HOH L 5 .   ? 36.862 -40.405 5.430   1.00 34.24 ? 530 HOH C O   1 
HETATM 4068 O O   . HOH L 5 .   ? 61.424 -29.032 23.680  1.00 12.29 ? 531 HOH C O   1 
HETATM 4069 O O   . HOH L 5 .   ? 48.705 -25.063 10.413  1.00 17.31 ? 532 HOH C O   1 
HETATM 4070 O O   . HOH L 5 .   ? 38.134 -48.047 25.701  1.00 22.44 ? 533 HOH C O   1 
HETATM 4071 O O   . HOH L 5 .   ? 34.905 -30.001 15.424  1.00 38.77 ? 534 HOH C O   1 
HETATM 4072 O O   . HOH L 5 .   ? 53.243 -50.090 11.383  1.00 36.22 ? 535 HOH C O   1 
HETATM 4073 O O   . HOH L 5 .   ? 42.097 -52.740 22.801  1.00 19.36 ? 536 HOH C O   1 
HETATM 4074 O O   . HOH L 5 .   ? 55.396 -24.571 29.007  1.00 15.07 ? 537 HOH C O   1 
HETATM 4075 O O   . HOH L 5 .   ? 45.790 -45.488 9.276   1.00 15.48 ? 538 HOH C O   1 
HETATM 4076 O O   . HOH L 5 .   ? 43.517 -47.724 34.659  1.00 23.92 ? 539 HOH C O   1 
HETATM 4077 O O   . HOH L 5 .   ? 34.539 -41.122 22.911  1.00 26.83 ? 540 HOH C O   1 
HETATM 4078 O O   . HOH L 5 .   ? 47.098 -41.558 31.163  1.00 34.23 ? 541 HOH C O   1 
HETATM 4079 O O   . HOH L 5 .   ? 50.553 -43.093 34.075  1.00 38.55 ? 542 HOH C O   1 
HETATM 4080 O O   . HOH L 5 .   ? 41.453 -26.725 19.633  1.00 32.57 ? 543 HOH C O   1 
HETATM 4081 O O   . HOH L 5 .   ? 36.387 -44.259 7.395   1.00 23.03 ? 544 HOH C O   1 
HETATM 4082 O O   . HOH L 5 .   ? 49.709 -46.117 29.259  1.00 19.68 ? 545 HOH C O   1 
HETATM 4083 O O   . HOH L 5 .   ? 65.516 -28.298 15.262  1.00 24.29 ? 546 HOH C O   1 
HETATM 4084 O O   . HOH L 5 .   ? 46.658 -37.113 2.604   1.00 33.96 ? 547 HOH C O   1 
HETATM 4085 O O   . HOH L 5 .   ? 49.757 -34.328 8.383   1.00 23.10 ? 548 HOH C O   1 
HETATM 4086 O O   . HOH L 5 .   ? 62.094 -35.362 21.977  1.00 23.75 ? 549 HOH C O   1 
HETATM 4087 O O   . HOH L 5 .   ? 40.201 -51.337 33.472  1.00 29.77 ? 550 HOH C O   1 
HETATM 4088 O O   . HOH L 5 .   ? 51.898 -50.447 15.780  1.00 23.39 ? 551 HOH C O   1 
HETATM 4089 O O   . HOH L 5 .   ? 56.166 -48.617 29.124  1.00 18.23 ? 552 HOH C O   1 
HETATM 4090 O O   . HOH L 5 .   ? 44.367 -46.323 2.526   1.00 29.90 ? 553 HOH C O   1 
HETATM 4091 O O   . HOH L 5 .   ? 33.748 -42.928 24.743  1.00 21.55 ? 554 HOH C O   1 
HETATM 4092 O O   . HOH L 5 .   ? 47.455 -41.225 0.774   1.00 37.69 ? 555 HOH C O   1 
HETATM 4093 O O   . HOH L 5 .   ? 30.748 -32.173 15.649  1.00 37.01 ? 556 HOH C O   1 
HETATM 4094 O O   . HOH L 5 .   ? 47.616 -32.776 21.859  1.00 18.82 ? 557 HOH C O   1 
HETATM 4095 O O   . HOH L 5 .   ? 66.072 -33.030 15.870  1.00 30.06 ? 558 HOH C O   1 
HETATM 4096 O O   . HOH L 5 .   ? 48.169 -56.571 24.489  1.00 21.03 ? 559 HOH C O   1 
HETATM 4097 O O   . HOH L 5 .   ? 59.503 -25.789 26.143  1.00 15.11 ? 560 HOH C O   1 
HETATM 4098 O O   . HOH L 5 .   ? 38.415 -27.414 17.420  1.00 29.66 ? 561 HOH C O   1 
HETATM 4099 O O   . HOH L 5 .   ? 61.722 -31.275 14.676  1.00 15.91 ? 562 HOH C O   1 
HETATM 4100 O O   . HOH L 5 .   ? 45.617 -54.752 17.352  1.00 21.77 ? 563 HOH C O   1 
HETATM 4101 O O   . HOH L 5 .   ? 47.503 -39.205 30.301  1.00 30.81 ? 564 HOH C O   1 
HETATM 4102 O O   . HOH L 5 .   ? 64.406 -25.075 5.614   1.00 24.87 ? 565 HOH C O   1 
HETATM 4103 O O   . HOH L 5 .   ? 47.120 -36.769 6.349   1.00 20.48 ? 566 HOH C O   1 
HETATM 4104 O O   . HOH L 5 .   ? 56.774 -36.127 9.724   1.00 31.07 ? 567 HOH C O   1 
HETATM 4105 O O   . HOH L 5 .   ? 44.221 -43.783 3.349   1.00 26.16 ? 568 HOH C O   1 
HETATM 4106 O O   . HOH L 5 .   ? 41.759 -38.876 27.308  1.00 17.58 ? 569 HOH C O   1 
HETATM 4107 O O   . HOH L 5 .   ? 47.196 -54.554 31.076  1.00 23.09 ? 570 HOH C O   1 
HETATM 4108 O O   . HOH L 5 .   ? 60.418 -37.061 23.226  1.00 25.30 ? 571 HOH C O   1 
HETATM 4109 O O   . HOH L 5 .   ? 51.553 -42.421 29.504  1.00 19.59 ? 572 HOH C O   1 
HETATM 4110 O O   . HOH L 5 .   ? 64.838 -24.886 2.886   1.00 29.15 ? 573 HOH C O   1 
HETATM 4111 O O   . HOH L 5 .   ? 57.140 -26.113 27.572  1.00 17.00 ? 574 HOH C O   1 
HETATM 4112 O O   . HOH L 5 .   ? 49.751 -26.663 28.394  1.00 18.32 ? 575 HOH C O   1 
HETATM 4113 O O   . HOH L 5 .   ? 30.047 -43.601 12.347  1.00 35.82 ? 576 HOH C O   1 
HETATM 4114 O O   . HOH L 5 .   ? 44.269 -54.101 29.429  1.00 20.38 ? 577 HOH C O   1 
HETATM 4115 O O   . HOH L 5 .   ? 57.084 -40.165 28.412  1.00 16.80 ? 578 HOH C O   1 
HETATM 4116 O O   . HOH L 5 .   ? 42.635 -42.469 5.027   1.00 29.92 ? 579 HOH C O   1 
HETATM 4117 O O   . HOH L 5 .   ? 47.138 -27.801 26.454  1.00 22.62 ? 580 HOH C O   1 
HETATM 4118 O O   . HOH L 5 .   ? 30.883 -30.713 8.118   1.00 31.32 ? 581 HOH C O   1 
HETATM 4119 O O   . HOH L 5 .   ? 43.546 -36.286 1.475   1.00 40.64 ? 582 HOH C O   1 
HETATM 4120 O O   . HOH L 5 .   ? 29.018 -36.327 8.803   1.00 28.76 ? 583 HOH C O   1 
HETATM 4121 O O   . HOH L 5 .   ? 37.362 -28.252 14.721  1.00 22.32 ? 584 HOH C O   1 
HETATM 4122 O O   . HOH L 5 .   ? 65.046 -25.220 13.106  1.00 24.60 ? 585 HOH C O   1 
HETATM 4123 O O   . HOH L 5 .   ? 46.348 -24.537 9.089   1.00 26.61 ? 586 HOH C O   1 
HETATM 4124 O O   . HOH L 5 .   ? 40.063 -34.957 22.476  1.00 24.00 ? 587 HOH C O   1 
HETATM 4125 O O   . HOH L 5 .   ? 35.661 -33.601 21.284  1.00 46.90 ? 588 HOH C O   1 
HETATM 4126 O O   . HOH L 5 .   ? 38.347 -26.320 10.359  1.00 34.37 ? 589 HOH C O   1 
HETATM 4127 O O   . HOH L 5 .   ? 35.156 -38.513 4.512   1.00 33.39 ? 590 HOH C O   1 
HETATM 4128 O O   . HOH L 5 .   ? 52.895 -54.590 20.162  1.00 26.37 ? 591 HOH C O   1 
HETATM 4129 O O   . HOH L 5 .   ? 39.368 -50.297 9.325   1.00 24.15 ? 592 HOH C O   1 
HETATM 4130 O O   . HOH L 5 .   ? 56.035 -29.401 2.834   1.00 32.32 ? 593 HOH C O   1 
HETATM 4131 O O   . HOH L 5 .   ? 54.850 -45.903 9.738   1.00 38.78 ? 594 HOH C O   1 
HETATM 4132 O O   . HOH L 5 .   ? 46.337 -26.319 6.543   1.00 39.02 ? 595 HOH C O   1 
HETATM 4133 O O   . HOH L 5 .   ? 56.186 -28.402 -0.228  1.00 35.36 ? 596 HOH C O   1 
HETATM 4134 O O   . HOH L 5 .   ? 41.745 -55.339 23.486  1.00 29.78 ? 597 HOH C O   1 
HETATM 4135 O O   . HOH L 5 .   ? 46.279 -22.088 21.863  1.00 26.37 ? 598 HOH C O   1 
HETATM 4136 O O   . HOH L 5 .   ? 63.778 -22.281 8.831   1.00 38.76 ? 599 HOH C O   1 
HETATM 4137 O O   . HOH L 5 .   ? 37.283 -49.886 11.270  1.00 31.80 ? 600 HOH C O   1 
HETATM 4138 O O   . HOH L 5 .   ? 47.965 -56.088 18.574  1.00 27.50 ? 601 HOH C O   1 
HETATM 4139 O O   . HOH L 5 .   ? 54.818 -44.045 31.770  1.00 33.36 ? 602 HOH C O   1 
HETATM 4140 O O   . HOH L 5 .   ? 38.958 -51.575 20.754  1.00 32.02 ? 603 HOH C O   1 
HETATM 4141 O O   . HOH L 5 .   ? 41.773 -51.512 9.652   1.00 38.55 ? 604 HOH C O   1 
HETATM 4142 O O   . HOH L 5 .   ? 34.608 -49.509 9.754   1.00 35.46 ? 605 HOH C O   1 
HETATM 4143 O O   . HOH L 5 .   ? 48.670 -27.541 6.710   1.00 32.08 ? 606 HOH C O   1 
HETATM 4144 O O   . HOH L 5 .   ? 32.363 -50.269 11.126  1.00 35.76 ? 607 HOH C O   1 
HETATM 4145 O O   . HOH L 5 .   ? 45.636 -31.892 24.046  1.00 37.34 ? 608 HOH C O   1 
HETATM 4146 O O   . HOH L 5 .   ? 53.995 -25.625 -3.227  1.00 40.65 ? 609 HOH C O   1 
HETATM 4147 O O   . HOH L 5 .   ? 65.207 -30.299 4.917   1.00 37.40 ? 610 HOH C O   1 
HETATM 4148 O O   . HOH L 5 .   ? 46.778 -26.746 3.107   1.00 47.65 ? 611 HOH C O   1 
HETATM 4149 O O   . HOH L 5 .   ? 55.046 -46.320 5.971   1.00 37.03 ? 612 HOH C O   1 
HETATM 4150 O O   . HOH L 5 .   ? 35.219 -41.725 7.174   1.00 34.07 ? 613 HOH C O   1 
HETATM 4151 O O   . HOH L 5 .   ? 40.506 -48.957 24.769  1.00 21.39 ? 614 HOH C O   1 
HETATM 4152 O O   . HOH L 5 .   ? 40.857 -54.759 18.652  1.00 34.69 ? 615 HOH C O   1 
HETATM 4153 O O   . HOH L 5 .   ? 47.969 -62.271 28.330  1.00 40.74 ? 616 HOH C O   1 
HETATM 4154 O O   . HOH L 5 .   ? 39.881 -51.152 23.325  1.00 25.59 ? 617 HOH C O   1 
HETATM 4155 O O   . HOH L 5 .   ? 41.438 -52.553 20.101  1.00 25.43 ? 618 HOH C O   1 
HETATM 4156 O O   . HOH L 5 .   ? 41.369 -49.438 35.274  1.00 28.95 ? 619 HOH C O   1 
HETATM 4157 O O   . HOH L 5 .   ? 53.179 -56.222 17.364  1.00 29.21 ? 620 HOH C O   1 
HETATM 4158 O O   . HOH L 5 .   ? 54.794 -28.039 -2.665  1.00 39.95 ? 621 HOH C O   1 
HETATM 4159 O O   . HOH L 5 .   ? 47.799 -34.840 4.391   1.00 36.08 ? 622 HOH C O   1 
HETATM 4160 O O   . HOH L 5 .   ? 42.561 -45.324 33.867  1.00 23.10 ? 623 HOH C O   1 
HETATM 4161 O O   . HOH L 5 .   ? 65.235 -29.431 12.937  1.00 39.00 ? 624 HOH C O   1 
HETATM 4162 O O   . HOH L 5 .   ? 33.803 -26.169 16.567  1.00 38.44 ? 625 HOH C O   1 
HETATM 4163 O O   . HOH L 5 .   ? 54.731 -48.606 13.017  1.00 37.36 ? 626 HOH C O   1 
HETATM 4164 O O   . HOH L 5 .   ? 32.799 -41.530 6.094   1.00 38.27 ? 627 HOH C O   1 
HETATM 4165 O O   . HOH L 5 .   ? 37.398 -34.591 22.770  1.00 35.00 ? 628 HOH C O   1 
HETATM 4166 O O   . HOH L 5 .   ? 52.748 -42.292 32.327  1.00 39.97 ? 629 HOH C O   1 
HETATM 4167 O O   . HOH L 5 .   ? 46.443 -31.348 28.557  1.00 36.72 ? 630 HOH C O   1 
HETATM 4168 O O   . HOH L 5 .   ? 47.281 -47.148 36.645  1.00 43.64 ? 631 HOH C O   1 
HETATM 4169 O O   . HOH L 5 .   ? 49.653 -42.812 31.452  1.00 30.44 ? 632 HOH C O   1 
HETATM 4170 O O   . HOH L 5 .   ? 56.154 -51.687 37.180  1.00 39.21 ? 633 HOH C O   1 
HETATM 4171 O O   . HOH L 5 .   ? 46.038 -58.463 25.515  1.00 26.44 ? 634 HOH C O   1 
HETATM 4172 O O   . HOH L 5 .   ? 64.449 -31.230 14.414  1.00 40.55 ? 635 HOH C O   1 
HETATM 4173 O O   . HOH L 5 .   ? 43.061 -55.775 17.210  1.00 29.26 ? 636 HOH C O   1 
HETATM 4174 O O   . HOH L 5 .   ? 49.553 -21.553 0.386   1.00 40.98 ? 637 HOH C O   1 
HETATM 4175 O O   . HOH L 5 .   ? 43.946 -54.640 13.044  1.00 41.65 ? 638 HOH C O   1 
HETATM 4176 O O   . HOH L 5 .   ? 37.712 -25.687 5.924   1.00 35.42 ? 639 HOH C O   1 
HETATM 4177 O O   . HOH L 5 .   ? 51.340 -25.196 -2.005  1.00 40.18 ? 640 HOH C O   1 
HETATM 4178 O O   . HOH L 5 .   ? 38.430 -44.485 5.504   1.00 40.22 ? 641 HOH C O   1 
HETATM 4179 O O   . HOH L 5 .   ? 33.795 -14.103 10.510  1.00 35.43 ? 642 HOH C O   1 
HETATM 4180 O O   . HOH L 5 .   ? 46.872 -25.072 26.499  1.00 36.88 ? 643 HOH C O   1 
HETATM 4181 O O   . HOH L 5 .   ? 41.890 -55.471 14.725  1.00 41.98 ? 644 HOH C O   1 
HETATM 4182 O O   . HOH L 5 .   ? 45.810 -38.388 31.767  1.00 37.01 ? 645 HOH C O   1 
HETATM 4183 O O   . HOH L 5 .   ? 41.751 -21.767 16.870  1.00 45.17 ? 646 HOH C O   1 
HETATM 4184 O O   . HOH L 5 .   ? 70.354 -33.086 14.750  1.00 42.16 ? 647 HOH C O   1 
HETATM 4185 O O   . HOH M 5 .   ? 62.648 -36.644 19.334  1.00 26.70 ? 501 HOH D O   1 
HETATM 4186 O O   . HOH M 5 .   ? 52.253 -21.135 2.644   1.00 28.79 ? 502 HOH D O   1 
HETATM 4187 O O   . HOH M 5 .   ? 70.015 -16.482 28.501  1.00 32.53 ? 503 HOH D O   1 
HETATM 4188 O O   . HOH M 5 .   ? 59.056 -13.459 24.262  1.00 30.96 ? 504 HOH D O   1 
HETATM 4189 O O   . HOH M 5 .   ? 50.815 -7.580  13.338  1.00 28.86 ? 505 HOH D O   1 
HETATM 4190 O O   . HOH M 5 .   ? 57.085 -13.780 31.074  1.00 26.30 ? 506 HOH D O   1 
HETATM 4191 O O   . HOH M 5 .   ? 50.527 -20.437 4.805   1.00 34.84 ? 507 HOH D O   1 
HETATM 4192 O O   . HOH M 5 .   ? 61.722 -35.314 25.726  1.00 18.84 ? 508 HOH D O   1 
HETATM 4193 O O   . HOH M 5 .   ? 60.867 -21.437 37.827  1.00 25.42 ? 509 HOH D O   1 
HETATM 4194 O O   . HOH M 5 .   ? 58.676 -45.458 15.667  1.00 24.25 ? 510 HOH D O   1 
HETATM 4195 O O   . HOH M 5 .   ? 47.169 -31.753 30.888  1.00 34.12 ? 511 HOH D O   1 
HETATM 4196 O O   . HOH M 5 .   ? 65.211 -22.489 13.941  1.00 33.87 ? 512 HOH D O   1 
HETATM 4197 O O   . HOH M 5 .   ? 68.046 -28.393 15.837  1.00 36.13 ? 513 HOH D O   1 
HETATM 4198 O O   . HOH M 5 .   ? 60.253 -10.529 29.818  1.00 28.27 ? 514 HOH D O   1 
HETATM 4199 O O   . HOH M 5 .   ? 74.013 -34.212 24.924  1.00 26.13 ? 515 HOH D O   1 
HETATM 4200 O O   . HOH M 5 .   ? 52.597 -12.290 6.208   1.00 31.58 ? 516 HOH D O   1 
HETATM 4201 O O   . HOH M 5 .   ? 48.151 -27.691 30.289  1.00 28.05 ? 517 HOH D O   1 
HETATM 4202 O O   . HOH M 5 .   ? 47.561 -13.953 14.268  1.00 38.78 ? 518 HOH D O   1 
HETATM 4203 O O   . HOH M 5 .   ? 70.782 -38.647 20.466  1.00 20.18 ? 519 HOH D O   1 
HETATM 4204 O O   . HOH M 5 .   ? 58.665 -34.123 37.877  1.00 38.05 ? 520 HOH D O   1 
HETATM 4205 O O   . HOH M 5 .   ? 62.670 -53.721 30.572  1.00 27.55 ? 521 HOH D O   1 
HETATM 4206 O O   . HOH M 5 .   ? 58.248 -12.259 17.649  1.00 25.01 ? 522 HOH D O   1 
HETATM 4207 O O   . HOH M 5 .   ? 62.457 -11.337 21.992  1.00 42.80 ? 523 HOH D O   1 
HETATM 4208 O O   . HOH M 5 .   ? 61.972 -14.901 26.004  1.00 19.72 ? 524 HOH D O   1 
HETATM 4209 O O   . HOH M 5 .   ? 52.527 -25.676 38.947  1.00 30.00 ? 525 HOH D O   1 
HETATM 4210 O O   . HOH M 5 .   ? 69.678 -29.303 19.586  1.00 14.35 ? 526 HOH D O   1 
HETATM 4211 O O   . HOH M 5 .   ? 66.083 -15.427 24.165  1.00 24.65 ? 527 HOH D O   1 
HETATM 4212 O O   . HOH M 5 .   ? 69.086 -35.748 18.041  1.00 28.21 ? 528 HOH D O   1 
HETATM 4213 O O   . HOH M 5 .   ? 48.358 -17.675 12.273  1.00 33.64 ? 529 HOH D O   1 
HETATM 4214 O O   . HOH M 5 .   ? 67.023 -16.848 22.188  1.00 28.25 ? 530 HOH D O   1 
HETATM 4215 O O   . HOH M 5 .   ? 70.148 -27.436 28.839  1.00 17.46 ? 531 HOH D O   1 
HETATM 4216 O O   . HOH M 5 .   ? 71.571 -27.272 31.383  1.00 27.04 ? 532 HOH D O   1 
HETATM 4217 O O   . HOH M 5 .   ? 76.516 -24.931 22.795  1.00 24.62 ? 533 HOH D O   1 
HETATM 4218 O O   . HOH M 5 .   ? 51.255 -31.702 8.626   1.00 30.75 ? 534 HOH D O   1 
HETATM 4219 O O   . HOH M 5 .   ? 47.911 -39.581 11.948  1.00 12.77 ? 535 HOH D O   1 
HETATM 4220 O O   . HOH M 5 .   ? 66.074 -25.044 34.692  1.00 28.98 ? 536 HOH D O   1 
HETATM 4221 O O   . HOH M 5 .   ? 53.843 -21.024 5.480   1.00 18.39 ? 537 HOH D O   1 
HETATM 4222 O O   . HOH M 5 .   ? 63.193 -39.295 25.925  1.00 24.34 ? 538 HOH D O   1 
HETATM 4223 O O   . HOH M 5 .   ? 60.622 -38.415 25.705  1.00 24.91 ? 539 HOH D O   1 
HETATM 4224 O O   . HOH M 5 .   ? 54.585 -40.726 29.472  1.00 15.84 ? 540 HOH D O   1 
HETATM 4225 O O   . HOH M 5 .   ? 47.161 -19.603 22.164  1.00 22.10 ? 541 HOH D O   1 
HETATM 4226 O O   . HOH M 5 .   ? 51.658 -27.757 36.959  1.00 29.42 ? 542 HOH D O   1 
HETATM 4227 O O   . HOH M 5 .   ? 47.437 -19.248 14.795  1.00 28.22 ? 543 HOH D O   1 
HETATM 4228 O O   . HOH M 5 .   ? 56.873 -52.322 27.908  1.00 19.79 ? 544 HOH D O   1 
HETATM 4229 O O   . HOH M 5 .   ? 60.206 -24.123 40.198  1.00 28.51 ? 545 HOH D O   1 
HETATM 4230 O O   . HOH M 5 .   ? 50.623 -12.885 25.347  1.00 21.35 ? 546 HOH D O   1 
HETATM 4231 O O   . HOH M 5 .   ? 66.477 -24.473 24.110  1.00 13.19 ? 547 HOH D O   1 
HETATM 4232 O O   . HOH M 5 .   ? 50.775 -18.989 11.661  1.00 19.36 ? 548 HOH D O   1 
HETATM 4233 O O   . HOH M 5 .   ? 70.853 -32.880 17.598  1.00 25.73 ? 549 HOH D O   1 
HETATM 4234 O O   . HOH M 5 .   ? 54.759 -14.607 3.569   1.00 40.88 ? 550 HOH D O   1 
HETATM 4235 O O   . HOH M 5 .   ? 49.379 -29.696 22.384  1.00 18.05 ? 551 HOH D O   1 
HETATM 4236 O O   . HOH M 5 .   ? 40.246 -37.502 16.444  1.00 14.61 ? 552 HOH D O   1 
HETATM 4237 O O   . HOH M 5 .   ? 64.465 -15.148 16.923  1.00 24.25 ? 553 HOH D O   1 
HETATM 4238 O O   . HOH M 5 .   ? 71.126 -21.477 19.510  1.00 22.58 ? 554 HOH D O   1 
HETATM 4239 O O   . HOH M 5 .   ? 46.227 -21.358 16.373  1.00 23.21 ? 555 HOH D O   1 
HETATM 4240 O O   . HOH M 5 .   ? 74.028 -28.937 21.319  1.00 27.92 ? 556 HOH D O   1 
HETATM 4241 O O   . HOH M 5 .   ? 66.113 -27.094 30.534  1.00 25.84 ? 557 HOH D O   1 
HETATM 4242 O O   . HOH M 5 .   ? 63.657 -19.184 10.116  1.00 41.02 ? 558 HOH D O   1 
HETATM 4243 O O   . HOH M 5 .   ? 65.910 -20.836 33.055  1.00 21.88 ? 559 HOH D O   1 
HETATM 4244 O O   . HOH M 5 .   ? 48.805 -30.491 33.940  1.00 27.01 ? 560 HOH D O   1 
HETATM 4245 O O   . HOH M 5 .   ? 72.257 -21.398 32.723  1.00 31.49 ? 561 HOH D O   1 
HETATM 4246 O O   . HOH M 5 .   ? 71.930 -28.664 15.789  1.00 29.18 ? 562 HOH D O   1 
HETATM 4247 O O   . HOH M 5 .   ? 53.582 -20.722 39.078  1.00 41.45 ? 563 HOH D O   1 
HETATM 4248 O O   . HOH M 5 .   ? 58.381 -40.334 10.965  1.00 31.57 ? 564 HOH D O   1 
HETATM 4249 O O   . HOH M 5 .   ? 59.668 -12.436 32.762  1.00 31.18 ? 565 HOH D O   1 
HETATM 4250 O O   . HOH M 5 .   ? 66.998 -21.296 16.445  1.00 30.43 ? 566 HOH D O   1 
HETATM 4251 O O   . HOH M 5 .   ? 60.692 -13.323 10.541  1.00 22.24 ? 567 HOH D O   1 
HETATM 4252 O O   . HOH M 5 .   ? 53.003 -10.383 16.230  1.00 27.03 ? 568 HOH D O   1 
HETATM 4253 O O   . HOH M 5 .   ? 76.422 -17.568 24.986  1.00 30.98 ? 569 HOH D O   1 
HETATM 4254 O O   . HOH M 5 .   ? 59.520 -52.993 27.362  1.00 22.22 ? 570 HOH D O   1 
HETATM 4255 O O   . HOH M 5 .   ? 64.361 -35.147 15.573  1.00 32.62 ? 571 HOH D O   1 
HETATM 4256 O O   . HOH M 5 .   ? 54.634 -10.858 8.706   1.00 23.44 ? 572 HOH D O   1 
HETATM 4257 O O   . HOH M 5 .   ? 43.840 -39.938 13.696  1.00 14.78 ? 573 HOH D O   1 
HETATM 4258 O O   . HOH M 5 .   ? 55.521 -14.322 33.860  1.00 31.06 ? 574 HOH D O   1 
HETATM 4259 O O   . HOH M 5 .   ? 54.841 -45.945 12.468  1.00 21.17 ? 575 HOH D O   1 
HETATM 4260 O O   . HOH M 5 .   ? 61.222 -34.421 34.481  1.00 34.66 ? 576 HOH D O   1 
HETATM 4261 O O   . HOH M 5 .   ? 55.597 -13.422 21.366  1.00 27.47 ? 577 HOH D O   1 
HETATM 4262 O O   . HOH M 5 .   ? 67.388 -19.980 19.777  1.00 22.72 ? 578 HOH D O   1 
HETATM 4263 O O   . HOH M 5 .   ? 77.448 -21.253 23.349  1.00 31.15 ? 579 HOH D O   1 
HETATM 4264 O O   . HOH M 5 .   ? 64.391 -32.565 35.744  1.00 36.44 ? 580 HOH D O   1 
HETATM 4265 O O   . HOH M 5 .   ? 56.485 -41.945 14.673  1.00 16.86 ? 581 HOH D O   1 
HETATM 4266 O O   . HOH M 5 .   ? 49.178 -27.569 3.434   1.00 42.01 ? 582 HOH D O   1 
HETATM 4267 O O   . HOH M 5 .   ? 72.008 -25.715 27.933  1.00 16.43 ? 583 HOH D O   1 
HETATM 4268 O O   . HOH M 5 .   ? 49.288 -22.183 11.959  1.00 29.24 ? 584 HOH D O   1 
HETATM 4269 O O   . HOH M 5 .   ? 42.910 -31.557 22.953  1.00 22.74 ? 585 HOH D O   1 
HETATM 4270 O O   . HOH M 5 .   ? 48.873 -24.047 27.601  1.00 24.46 ? 586 HOH D O   1 
HETATM 4271 O O   . HOH M 5 .   ? 64.373 -32.767 27.785  1.00 20.82 ? 587 HOH D O   1 
HETATM 4272 O O   . HOH M 5 .   ? 52.979 -36.065 9.336   1.00 28.13 ? 588 HOH D O   1 
HETATM 4273 O O   . HOH M 5 .   ? 41.063 -33.068 20.516  1.00 19.31 ? 589 HOH D O   1 
HETATM 4274 O O   . HOH M 5 .   ? 54.972 -10.099 11.912  1.00 29.67 ? 590 HOH D O   1 
HETATM 4275 O O   . HOH M 5 .   ? 42.486 -37.798 14.996  1.00 17.25 ? 591 HOH D O   1 
HETATM 4276 O O   . HOH M 5 .   ? 47.911 -15.172 19.895  1.00 31.65 ? 592 HOH D O   1 
HETATM 4277 O O   . HOH M 5 .   ? 55.000 -40.219 32.117  1.00 25.02 ? 593 HOH D O   1 
HETATM 4278 O O   . HOH M 5 .   ? 58.457 -48.536 31.648  1.00 40.29 ? 594 HOH D O   1 
HETATM 4279 O O   . HOH M 5 .   ? 51.076 -14.557 16.677  1.00 21.56 ? 595 HOH D O   1 
HETATM 4280 O O   . HOH M 5 .   ? 49.503 -27.504 9.374   1.00 21.95 ? 596 HOH D O   1 
HETATM 4281 O O   . HOH M 5 .   ? 59.684 -52.062 18.812  1.00 41.15 ? 597 HOH D O   1 
HETATM 4282 O O   . HOH M 5 .   ? 54.461 -49.148 15.389  1.00 32.50 ? 598 HOH D O   1 
HETATM 4283 O O   . HOH M 5 .   ? 48.932 -13.300 16.251  1.00 36.86 ? 599 HOH D O   1 
HETATM 4284 O O   . HOH M 5 .   ? 70.891 -24.610 16.175  1.00 35.61 ? 600 HOH D O   1 
HETATM 4285 O O   . HOH M 5 .   ? 45.988 -18.965 10.525  1.00 35.69 ? 601 HOH D O   1 
HETATM 4286 O O   . HOH M 5 .   ? 52.945 -7.527  8.531   1.00 32.43 ? 602 HOH D O   1 
HETATM 4287 O O   . HOH M 5 .   ? 59.159 -33.576 11.580  1.00 31.51 ? 603 HOH D O   1 
HETATM 4288 O O   . HOH M 5 .   ? 59.437 -12.361 26.711  1.00 28.97 ? 604 HOH D O   1 
HETATM 4289 O O   . HOH M 5 .   ? 56.899 -42.570 10.089  1.00 28.80 ? 605 HOH D O   1 
HETATM 4290 O O   . HOH M 5 .   ? 67.170 -33.501 32.863  1.00 32.26 ? 606 HOH D O   1 
HETATM 4291 O O   . HOH M 5 .   ? 48.955 -22.281 8.034   1.00 35.48 ? 607 HOH D O   1 
HETATM 4292 O O   . HOH M 5 .   ? 46.041 -11.401 14.797  1.00 26.87 ? 608 HOH D O   1 
HETATM 4293 O O   . HOH M 5 .   ? 67.922 -17.225 27.264  1.00 20.78 ? 609 HOH D O   1 
HETATM 4294 O O   . HOH M 5 .   ? 65.666 -15.712 27.881  1.00 22.44 ? 610 HOH D O   1 
HETATM 4295 O O   . HOH M 5 .   ? 51.584 -30.714 35.705  1.00 23.10 ? 611 HOH D O   1 
HETATM 4296 O O   . HOH M 5 .   ? 45.598 -32.643 26.646  1.00 39.78 ? 612 HOH D O   1 
HETATM 4297 O O   . HOH M 5 .   ? 59.422 -10.016 16.511  1.00 41.52 ? 613 HOH D O   1 
HETATM 4298 O O   . HOH M 5 .   ? 43.213 -35.470 26.208  1.00 43.94 ? 614 HOH D O   1 
HETATM 4299 O O   . HOH M 5 .   ? 71.914 -16.883 26.459  1.00 41.27 ? 615 HOH D O   1 
HETATM 4300 O O   . HOH M 5 .   ? 52.665 -33.732 9.761   1.00 27.48 ? 616 HOH D O   1 
HETATM 4301 O O   . HOH M 5 .   ? 64.210 -15.799 13.002  1.00 29.09 ? 617 HOH D O   1 
HETATM 4302 O O   . HOH M 5 .   ? 60.431 -8.828  10.919  1.00 38.20 ? 618 HOH D O   1 
HETATM 4303 O O   . HOH M 5 .   ? 60.401 -12.936 36.452  1.00 39.84 ? 619 HOH D O   1 
HETATM 4304 O O   . HOH M 5 .   ? 58.166 -39.660 32.490  1.00 33.86 ? 620 HOH D O   1 
HETATM 4305 O O   . HOH M 5 .   ? 47.094 -28.052 23.058  1.00 33.86 ? 621 HOH D O   1 
HETATM 4306 O O   . HOH M 5 .   ? 66.745 -16.661 17.064  1.00 37.57 ? 622 HOH D O   1 
HETATM 4307 O O   . HOH M 5 .   ? 63.350 -11.478 25.129  1.00 35.21 ? 623 HOH D O   1 
HETATM 4308 O O   . HOH M 5 .   ? 68.051 -22.125 32.120  1.00 36.85 ? 624 HOH D O   1 
HETATM 4309 O O   . HOH M 5 .   ? 59.657 -14.642 37.956  1.00 30.76 ? 625 HOH D O   1 
HETATM 4310 O O   . HOH M 5 .   ? 43.388 -37.152 28.000  1.00 30.13 ? 626 HOH D O   1 
HETATM 4311 O O   . HOH M 5 .   ? 72.443 -34.331 26.999  1.00 37.68 ? 627 HOH D O   1 
HETATM 4312 O O   . HOH M 5 .   ? 67.761 -18.570 15.842  1.00 37.58 ? 628 HOH D O   1 
HETATM 4313 O O   . HOH M 5 .   ? 67.843 -19.584 34.296  1.00 30.31 ? 629 HOH D O   1 
HETATM 4314 O O   . HOH M 5 .   ? 75.022 -33.364 35.165  1.00 36.70 ? 630 HOH D O   1 
HETATM 4315 O O   . HOH M 5 .   ? 52.549 -14.772 38.191  1.00 40.08 ? 631 HOH D O   1 
HETATM 4316 O O   . HOH M 5 .   ? 51.132 -28.547 2.124   1.00 45.50 ? 632 HOH D O   1 
HETATM 4317 O O   . HOH M 5 .   ? 56.974 -14.933 40.250  1.00 36.38 ? 633 HOH D O   1 
HETATM 4318 O O   . HOH M 5 .   ? 64.967 -22.641 35.056  1.00 25.85 ? 634 HOH D O   1 
HETATM 4319 O O   . HOH M 5 .   ? 72.990 -34.779 18.012  1.00 34.32 ? 635 HOH D O   1 
HETATM 4320 O O   . HOH M 5 .   ? 55.403 -9.424  18.824  1.00 34.97 ? 636 HOH D O   1 
HETATM 4321 O O   . HOH M 5 .   ? 64.920 -35.110 28.747  1.00 39.68 ? 637 HOH D O   1 
HETATM 4322 O O   . HOH M 5 .   ? 71.439 -36.961 18.238  1.00 28.98 ? 638 HOH D O   1 
HETATM 4323 O O   . HOH M 5 .   ? 59.472 -12.929 19.993  1.00 31.31 ? 639 HOH D O   1 
HETATM 4324 O O   . HOH M 5 .   ? 64.233 -40.038 36.332  1.00 40.55 ? 640 HOH D O   1 
HETATM 4325 O O   . HOH M 5 .   ? 71.446 -30.251 17.733  1.00 24.60 ? 641 HOH D O   1 
HETATM 4326 O O   . HOH M 5 .   ? 47.760 -20.248 26.020  1.00 35.76 ? 642 HOH D O   1 
HETATM 4327 O O   . HOH M 5 .   ? 47.964 -22.434 29.617  1.00 30.54 ? 643 HOH D O   1 
HETATM 4328 O O   . HOH M 5 .   ? 62.059 -42.492 19.336  1.00 35.03 ? 644 HOH D O   1 
HETATM 4329 O O   . HOH M 5 .   ? 56.743 -43.572 12.553  1.00 36.89 ? 645 HOH D O   1 
HETATM 4330 O O   . HOH M 5 .   ? 46.657 -23.887 2.175   1.00 43.75 ? 646 HOH D O   1 
HETATM 4331 O O   . HOH M 5 .   ? 45.783 -29.400 24.303  1.00 44.08 ? 647 HOH D O   1 
HETATM 4332 O O   . HOH M 5 .   ? 70.327 -21.951 16.858  1.00 38.02 ? 648 HOH D O   1 
HETATM 4333 O O   . HOH M 5 .   ? 45.201 -33.612 31.222  1.00 42.49 ? 649 HOH D O   1 
HETATM 4334 O O   . HOH M 5 .   ? 55.409 -12.254 19.061  1.00 35.01 ? 650 HOH D O   1 
HETATM 4335 O O   . HOH M 5 .   ? 67.981 -34.003 14.172  1.00 46.31 ? 651 HOH D O   1 
HETATM 4336 O O   . HOH M 5 .   ? 62.313 -19.527 38.922  1.00 31.44 ? 652 HOH D O   1 
HETATM 4337 O O   . HOH M 5 .   ? 47.125 -21.394 10.502  1.00 33.56 ? 653 HOH D O   1 
HETATM 4338 O O   . HOH M 5 .   ? 70.242 -28.421 13.627  1.00 32.41 ? 654 HOH D O   1 
HETATM 4339 O O   . HOH M 5 .   ? 69.912 -19.026 20.012  1.00 30.43 ? 655 HOH D O   1 
HETATM 4340 O O   . HOH M 5 .   ? 69.687 -20.028 36.074  1.00 38.10 ? 656 HOH D O   1 
HETATM 4341 O O   . HOH M 5 .   ? 65.547 -28.108 39.028  1.00 46.92 ? 657 HOH D O   1 
HETATM 4342 O O   . HOH M 5 .   ? 69.113 -27.672 35.472  1.00 43.04 ? 658 HOH D O   1 
HETATM 4343 O O   . HOH M 5 .   ? 65.052 -13.195 18.686  1.00 31.79 ? 659 HOH D O   1 
HETATM 4344 O O   . HOH M 5 .   ? 67.916 -15.512 20.124  1.00 42.70 ? 660 HOH D O   1 
HETATM 4345 O O   . HOH M 5 .   ? 49.151 -25.963 36.497  1.00 40.12 ? 661 HOH D O   1 
HETATM 4346 O O   . HOH M 5 .   ? 45.883 -19.324 24.356  1.00 31.36 ? 662 HOH D O   1 
HETATM 4347 O O   . HOH M 5 .   ? 46.736 -36.375 33.496  1.00 42.32 ? 663 HOH D O   1 
HETATM 4348 O O   . HOH M 5 .   ? 65.272 -14.377 14.520  1.00 38.55 ? 664 HOH D O   1 
HETATM 4349 O O   . HOH M 5 .   ? 63.126 -14.272 10.889  1.00 30.69 ? 665 HOH D O   1 
HETATM 4350 O O   . HOH M 5 .   ? 42.603 -32.566 27.323  1.00 44.20 ? 666 HOH D O   1 
HETATM 4351 O O   . HOH M 5 .   ? 59.114 -40.879 30.094  1.00 28.91 ? 667 HOH D O   1 
HETATM 4352 O O   . HOH M 5 .   ? 56.788 -12.908 5.011   1.00 34.82 ? 668 HOH D O   1 
HETATM 4353 O O   . HOH M 5 .   ? 44.109 -20.550 18.311  1.00 38.72 ? 669 HOH D O   1 
HETATM 4354 O O   . HOH M 5 .   ? 73.706 -21.210 18.865  1.00 32.44 ? 670 HOH D O   1 
HETATM 4355 O O   . HOH M 5 .   ? 63.965 -52.920 16.148  1.00 41.27 ? 671 HOH D O   1 
# 
