data_9F0K
# 
_entry.id   9F0K 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9F0K         pdb_00009f0k 10.2210/pdb9f0k/pdb 
WWPDB D_1292137925 ?            ?                   
EMDB  EMD-50112    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9F0K 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-16 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        
'Poliovirus type 1 (strain Mahoney) stabilised virus-like particle (PV1 SC6b) from a mammalian expression system.' 
_pdbx_database_related.db_id          EMD-50112 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              dave.stuart@strubi.ox.ac.uk 
_pdbx_contact_author.name_first         David 
_pdbx_contact_author.name_last          Stuart 
_pdbx_contact_author.name_mi            I. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3426-4210 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bahar, M.W.'  1 0000-0002-2350-2682 
'Porta, C.'    2 0000-0002-6788-4141 
'Fry, E.E.'    3 0000-0001-9754-5303 
'Stuart, D.I.' 4 0000-0002-3426-4210 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                831 
_citation.page_last                 831 
_citation.title                     
'Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-025-56118-z 
_citation.pdbx_database_id_PubMed   39827284 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sherry, L.'         1  0000-0002-4367-772X 
primary 'Bahar, M.W.'        2  0000-0002-2350-2682 
primary 'Porta, C.'          3  ?                   
primary 'Fox, H.'            4  ?                   
primary 'Grehan, K.'         5  0000-0003-3976-756X 
primary 'Nasta, V.'          6  ?                   
primary 'Duyvesteyn, H.M.E.' 7  ?                   
primary 'De Colibus, L.'     8  ?                   
primary 'Marsian, J.'        9  ?                   
primary 'Murdoch, I.'        10 ?                   
primary 'Ponndorf, D.'       11 ?                   
primary 'Kim, S.R.'          12 ?                   
primary 'Shah, S.'           13 ?                   
primary 'Carlyle, S.'        14 0000-0002-7158-8134 
primary 'Swanson, J.J.'      15 ?                   
primary 'Matthews, S.'       16 ?                   
primary 'Nicol, C.'          17 ?                   
primary 'Lomonossoff, G.P.'  18 0000-0003-0700-906X 
primary 'Macadam, A.J.'      19 0000-0002-8687-1573 
primary 'Fry, E.E.'          20 0000-0001-9754-5303 
primary 'Stuart, D.I.'       21 0000-0002-3426-4210 
primary 'Stonehouse, N.J.'   22 0000-0003-1146-5519 
primary 'Rowlands, D.J.'     23 0000-0002-4742-9272 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Capsid protein VP1' 33447.586 1 ? 'VP1 H248P'                    ? ? 
2 polymer man 'Capsid protein VP0' 37465.812 1 ? 'VP2 T25A, VP2 D57E, VP4 R18G' ? ? 
3 polymer man 'Capsid protein VP3' 26550.549 1 ? 'VP3 L119M, VP3 Q178L'         ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'P1D,Virion protein 1' 
2 VP4-VP2                
3 'P1C,Virion protein 3' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESF
FARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYV
PPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGIL
AVRVVNDPNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY
;
;GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESF
FARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYV
PPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGIL
AVRVVNDPNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY
;
A ? 
2 'polypeptide(L)' no no 
;MGAQVSSQKVGAHENSNGAYGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSD
RVLQLTLGNSTITAQEAANSVVAYGRWPEYLRDSEANPVDQPTEPEVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGL
FGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPA
RRFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITL
TIAPMCCEFNGLRNITLPRLQ
;
;MGAQVSSQKVGAHENSNGAYGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSD
RVLQLTLGNSTITAQEAANSVVAYGRWPEYLRDSEANPVDQPTEPEVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGL
FGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPA
RRFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITL
TIAPMCCEFNGLRNITLPRLQ
;
B ? 
3 'polypeptide(L)' no no 
;GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDD
PILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFMFCGSMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRLTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQ
;
;GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDD
PILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFMFCGSMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRLTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQ
;
C ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   LEU n 
1 3   GLY n 
1 4   GLN n 
1 5   MET n 
1 6   LEU n 
1 7   GLU n 
1 8   SER n 
1 9   MET n 
1 10  ILE n 
1 11  ASP n 
1 12  ASN n 
1 13  THR n 
1 14  VAL n 
1 15  ARG n 
1 16  GLU n 
1 17  THR n 
1 18  VAL n 
1 19  GLY n 
1 20  ALA n 
1 21  ALA n 
1 22  THR n 
1 23  SER n 
1 24  ARG n 
1 25  ASP n 
1 26  ALA n 
1 27  LEU n 
1 28  PRO n 
1 29  ASN n 
1 30  THR n 
1 31  GLU n 
1 32  ALA n 
1 33  SER n 
1 34  GLY n 
1 35  PRO n 
1 36  THR n 
1 37  HIS n 
1 38  SER n 
1 39  LYS n 
1 40  GLU n 
1 41  ILE n 
1 42  PRO n 
1 43  ALA n 
1 44  LEU n 
1 45  THR n 
1 46  ALA n 
1 47  VAL n 
1 48  GLU n 
1 49  THR n 
1 50  GLY n 
1 51  ALA n 
1 52  THR n 
1 53  ASN n 
1 54  PRO n 
1 55  LEU n 
1 56  VAL n 
1 57  PRO n 
1 58  SER n 
1 59  ASP n 
1 60  THR n 
1 61  VAL n 
1 62  GLN n 
1 63  THR n 
1 64  ARG n 
1 65  HIS n 
1 66  VAL n 
1 67  VAL n 
1 68  GLN n 
1 69  HIS n 
1 70  ARG n 
1 71  SER n 
1 72  ARG n 
1 73  SER n 
1 74  GLU n 
1 75  SER n 
1 76  SER n 
1 77  ILE n 
1 78  GLU n 
1 79  SER n 
1 80  PHE n 
1 81  PHE n 
1 82  ALA n 
1 83  ARG n 
1 84  GLY n 
1 85  ALA n 
1 86  CYS n 
1 87  VAL n 
1 88  THR n 
1 89  ILE n 
1 90  MET n 
1 91  THR n 
1 92  VAL n 
1 93  ASP n 
1 94  ASN n 
1 95  PRO n 
1 96  ALA n 
1 97  SER n 
1 98  THR n 
1 99  THR n 
1 100 ASN n 
1 101 LYS n 
1 102 ASP n 
1 103 LYS n 
1 104 LEU n 
1 105 PHE n 
1 106 ALA n 
1 107 VAL n 
1 108 TRP n 
1 109 LYS n 
1 110 ILE n 
1 111 THR n 
1 112 TYR n 
1 113 LYS n 
1 114 ASP n 
1 115 THR n 
1 116 VAL n 
1 117 GLN n 
1 118 LEU n 
1 119 ARG n 
1 120 ARG n 
1 121 LYS n 
1 122 LEU n 
1 123 GLU n 
1 124 PHE n 
1 125 PHE n 
1 126 THR n 
1 127 TYR n 
1 128 SER n 
1 129 ARG n 
1 130 PHE n 
1 131 ASP n 
1 132 MET n 
1 133 GLU n 
1 134 LEU n 
1 135 THR n 
1 136 PHE n 
1 137 VAL n 
1 138 VAL n 
1 139 THR n 
1 140 ALA n 
1 141 ASN n 
1 142 PHE n 
1 143 THR n 
1 144 GLU n 
1 145 THR n 
1 146 ASN n 
1 147 ASN n 
1 148 GLY n 
1 149 HIS n 
1 150 ALA n 
1 151 LEU n 
1 152 ASN n 
1 153 GLN n 
1 154 VAL n 
1 155 TYR n 
1 156 GLN n 
1 157 ILE n 
1 158 MET n 
1 159 TYR n 
1 160 VAL n 
1 161 PRO n 
1 162 PRO n 
1 163 GLY n 
1 164 ALA n 
1 165 PRO n 
1 166 VAL n 
1 167 PRO n 
1 168 GLU n 
1 169 LYS n 
1 170 TRP n 
1 171 ASP n 
1 172 ASP n 
1 173 TYR n 
1 174 THR n 
1 175 TRP n 
1 176 GLN n 
1 177 THR n 
1 178 SER n 
1 179 SER n 
1 180 ASN n 
1 181 PRO n 
1 182 SER n 
1 183 ILE n 
1 184 PHE n 
1 185 TYR n 
1 186 THR n 
1 187 TYR n 
1 188 GLY n 
1 189 THR n 
1 190 ALA n 
1 191 PRO n 
1 192 ALA n 
1 193 ARG n 
1 194 ILE n 
1 195 SER n 
1 196 VAL n 
1 197 PRO n 
1 198 TYR n 
1 199 VAL n 
1 200 GLY n 
1 201 ILE n 
1 202 SER n 
1 203 ASN n 
1 204 ALA n 
1 205 TYR n 
1 206 SER n 
1 207 HIS n 
1 208 PHE n 
1 209 TYR n 
1 210 ASP n 
1 211 GLY n 
1 212 PHE n 
1 213 SER n 
1 214 LYS n 
1 215 VAL n 
1 216 PRO n 
1 217 LEU n 
1 218 LYS n 
1 219 ASP n 
1 220 GLN n 
1 221 SER n 
1 222 ALA n 
1 223 ALA n 
1 224 LEU n 
1 225 GLY n 
1 226 ASP n 
1 227 SER n 
1 228 LEU n 
1 229 TYR n 
1 230 GLY n 
1 231 ALA n 
1 232 ALA n 
1 233 SER n 
1 234 LEU n 
1 235 ASN n 
1 236 ASP n 
1 237 PHE n 
1 238 GLY n 
1 239 ILE n 
1 240 LEU n 
1 241 ALA n 
1 242 VAL n 
1 243 ARG n 
1 244 VAL n 
1 245 VAL n 
1 246 ASN n 
1 247 ASP n 
1 248 PRO n 
1 249 ASN n 
1 250 PRO n 
1 251 THR n 
1 252 LYS n 
1 253 VAL n 
1 254 THR n 
1 255 SER n 
1 256 LYS n 
1 257 ILE n 
1 258 ARG n 
1 259 VAL n 
1 260 TYR n 
1 261 LEU n 
1 262 LYS n 
1 263 PRO n 
1 264 LYS n 
1 265 HIS n 
1 266 ILE n 
1 267 ARG n 
1 268 VAL n 
1 269 TRP n 
1 270 CYS n 
1 271 PRO n 
1 272 ARG n 
1 273 PRO n 
1 274 PRO n 
1 275 ARG n 
1 276 ALA n 
1 277 VAL n 
1 278 ALA n 
1 279 TYR n 
1 280 TYR n 
1 281 GLY n 
1 282 PRO n 
1 283 GLY n 
1 284 VAL n 
1 285 ASP n 
1 286 TYR n 
1 287 LYS n 
1 288 ASP n 
1 289 GLY n 
1 290 THR n 
1 291 LEU n 
1 292 THR n 
1 293 PRO n 
1 294 LEU n 
1 295 SER n 
1 296 THR n 
1 297 LYS n 
1 298 ASP n 
1 299 LEU n 
1 300 THR n 
1 301 THR n 
1 302 TYR n 
2 1   MET n 
2 2   GLY n 
2 3   ALA n 
2 4   GLN n 
2 5   VAL n 
2 6   SER n 
2 7   SER n 
2 8   GLN n 
2 9   LYS n 
2 10  VAL n 
2 11  GLY n 
2 12  ALA n 
2 13  HIS n 
2 14  GLU n 
2 15  ASN n 
2 16  SER n 
2 17  ASN n 
2 18  GLY n 
2 19  ALA n 
2 20  TYR n 
2 21  GLY n 
2 22  GLY n 
2 23  SER n 
2 24  THR n 
2 25  ILE n 
2 26  ASN n 
2 27  TYR n 
2 28  THR n 
2 29  THR n 
2 30  ILE n 
2 31  ASN n 
2 32  TYR n 
2 33  TYR n 
2 34  ARG n 
2 35  ASP n 
2 36  SER n 
2 37  ALA n 
2 38  SER n 
2 39  ASN n 
2 40  ALA n 
2 41  ALA n 
2 42  SER n 
2 43  LYS n 
2 44  GLN n 
2 45  ASP n 
2 46  PHE n 
2 47  SER n 
2 48  GLN n 
2 49  ASP n 
2 50  PRO n 
2 51  SER n 
2 52  LYS n 
2 53  PHE n 
2 54  THR n 
2 55  GLU n 
2 56  PRO n 
2 57  ILE n 
2 58  LYS n 
2 59  ASP n 
2 60  VAL n 
2 61  LEU n 
2 62  ILE n 
2 63  LYS n 
2 64  THR n 
2 65  ALA n 
2 66  PRO n 
2 67  MET n 
2 68  LEU n 
2 69  ASN n 
2 70  SER n 
2 71  PRO n 
2 72  ASN n 
2 73  ILE n 
2 74  GLU n 
2 75  ALA n 
2 76  CYS n 
2 77  GLY n 
2 78  TYR n 
2 79  SER n 
2 80  ASP n 
2 81  ARG n 
2 82  VAL n 
2 83  LEU n 
2 84  GLN n 
2 85  LEU n 
2 86  THR n 
2 87  LEU n 
2 88  GLY n 
2 89  ASN n 
2 90  SER n 
2 91  THR n 
2 92  ILE n 
2 93  THR n 
2 94  ALA n 
2 95  GLN n 
2 96  GLU n 
2 97  ALA n 
2 98  ALA n 
2 99  ASN n 
2 100 SER n 
2 101 VAL n 
2 102 VAL n 
2 103 ALA n 
2 104 TYR n 
2 105 GLY n 
2 106 ARG n 
2 107 TRP n 
2 108 PRO n 
2 109 GLU n 
2 110 TYR n 
2 111 LEU n 
2 112 ARG n 
2 113 ASP n 
2 114 SER n 
2 115 GLU n 
2 116 ALA n 
2 117 ASN n 
2 118 PRO n 
2 119 VAL n 
2 120 ASP n 
2 121 GLN n 
2 122 PRO n 
2 123 THR n 
2 124 GLU n 
2 125 PRO n 
2 126 GLU n 
2 127 VAL n 
2 128 ALA n 
2 129 ALA n 
2 130 CYS n 
2 131 ARG n 
2 132 PHE n 
2 133 TYR n 
2 134 THR n 
2 135 LEU n 
2 136 ASP n 
2 137 THR n 
2 138 VAL n 
2 139 SER n 
2 140 TRP n 
2 141 THR n 
2 142 LYS n 
2 143 GLU n 
2 144 SER n 
2 145 ARG n 
2 146 GLY n 
2 147 TRP n 
2 148 TRP n 
2 149 TRP n 
2 150 LYS n 
2 151 LEU n 
2 152 PRO n 
2 153 ASP n 
2 154 ALA n 
2 155 LEU n 
2 156 ARG n 
2 157 ASP n 
2 158 MET n 
2 159 GLY n 
2 160 LEU n 
2 161 PHE n 
2 162 GLY n 
2 163 GLN n 
2 164 ASN n 
2 165 MET n 
2 166 TYR n 
2 167 TYR n 
2 168 HIS n 
2 169 TYR n 
2 170 LEU n 
2 171 GLY n 
2 172 ARG n 
2 173 SER n 
2 174 GLY n 
2 175 TYR n 
2 176 THR n 
2 177 VAL n 
2 178 HIS n 
2 179 VAL n 
2 180 GLN n 
2 181 CYS n 
2 182 ASN n 
2 183 ALA n 
2 184 SER n 
2 185 LYS n 
2 186 PHE n 
2 187 HIS n 
2 188 GLN n 
2 189 GLY n 
2 190 ALA n 
2 191 LEU n 
2 192 GLY n 
2 193 VAL n 
2 194 PHE n 
2 195 ALA n 
2 196 VAL n 
2 197 PRO n 
2 198 GLU n 
2 199 MET n 
2 200 CYS n 
2 201 LEU n 
2 202 ALA n 
2 203 GLY n 
2 204 ASP n 
2 205 SER n 
2 206 ASN n 
2 207 THR n 
2 208 THR n 
2 209 THR n 
2 210 MET n 
2 211 HIS n 
2 212 THR n 
2 213 SER n 
2 214 TYR n 
2 215 GLN n 
2 216 ASN n 
2 217 ALA n 
2 218 ASN n 
2 219 PRO n 
2 220 GLY n 
2 221 GLU n 
2 222 LYS n 
2 223 GLY n 
2 224 GLY n 
2 225 THR n 
2 226 PHE n 
2 227 THR n 
2 228 GLY n 
2 229 THR n 
2 230 PHE n 
2 231 THR n 
2 232 PRO n 
2 233 ASP n 
2 234 ASN n 
2 235 ASN n 
2 236 GLN n 
2 237 THR n 
2 238 SER n 
2 239 PRO n 
2 240 ALA n 
2 241 ARG n 
2 242 ARG n 
2 243 PHE n 
2 244 CYS n 
2 245 PRO n 
2 246 VAL n 
2 247 ASP n 
2 248 TYR n 
2 249 LEU n 
2 250 LEU n 
2 251 GLY n 
2 252 ASN n 
2 253 GLY n 
2 254 THR n 
2 255 LEU n 
2 256 LEU n 
2 257 GLY n 
2 258 ASN n 
2 259 ALA n 
2 260 PHE n 
2 261 VAL n 
2 262 PHE n 
2 263 PRO n 
2 264 HIS n 
2 265 GLN n 
2 266 ILE n 
2 267 ILE n 
2 268 ASN n 
2 269 LEU n 
2 270 ARG n 
2 271 THR n 
2 272 ASN n 
2 273 ASN n 
2 274 CYS n 
2 275 ALA n 
2 276 THR n 
2 277 LEU n 
2 278 VAL n 
2 279 LEU n 
2 280 PRO n 
2 281 TYR n 
2 282 VAL n 
2 283 ASN n 
2 284 SER n 
2 285 LEU n 
2 286 SER n 
2 287 ILE n 
2 288 ASP n 
2 289 SER n 
2 290 MET n 
2 291 VAL n 
2 292 LYS n 
2 293 HIS n 
2 294 ASN n 
2 295 ASN n 
2 296 TRP n 
2 297 GLY n 
2 298 ILE n 
2 299 ALA n 
2 300 ILE n 
2 301 LEU n 
2 302 PRO n 
2 303 LEU n 
2 304 ALA n 
2 305 PRO n 
2 306 LEU n 
2 307 ASN n 
2 308 PHE n 
2 309 ALA n 
2 310 SER n 
2 311 GLU n 
2 312 SER n 
2 313 SER n 
2 314 PRO n 
2 315 GLU n 
2 316 ILE n 
2 317 PRO n 
2 318 ILE n 
2 319 THR n 
2 320 LEU n 
2 321 THR n 
2 322 ILE n 
2 323 ALA n 
2 324 PRO n 
2 325 MET n 
2 326 CYS n 
2 327 CYS n 
2 328 GLU n 
2 329 PHE n 
2 330 ASN n 
2 331 GLY n 
2 332 LEU n 
2 333 ARG n 
2 334 ASN n 
2 335 ILE n 
2 336 THR n 
2 337 LEU n 
2 338 PRO n 
2 339 ARG n 
2 340 LEU n 
2 341 GLN n 
3 1   GLY n 
3 2   LEU n 
3 3   PRO n 
3 4   VAL n 
3 5   MET n 
3 6   ASN n 
3 7   THR n 
3 8   PRO n 
3 9   GLY n 
3 10  SER n 
3 11  ASN n 
3 12  GLN n 
3 13  TYR n 
3 14  LEU n 
3 15  THR n 
3 16  ALA n 
3 17  ASP n 
3 18  ASN n 
3 19  PHE n 
3 20  GLN n 
3 21  SER n 
3 22  PRO n 
3 23  CYS n 
3 24  ALA n 
3 25  LEU n 
3 26  PRO n 
3 27  GLU n 
3 28  PHE n 
3 29  ASP n 
3 30  VAL n 
3 31  THR n 
3 32  PRO n 
3 33  PRO n 
3 34  ILE n 
3 35  ASP n 
3 36  ILE n 
3 37  PRO n 
3 38  GLY n 
3 39  GLU n 
3 40  VAL n 
3 41  LYS n 
3 42  ASN n 
3 43  MET n 
3 44  MET n 
3 45  GLU n 
3 46  LEU n 
3 47  ALA n 
3 48  GLU n 
3 49  ILE n 
3 50  ASP n 
3 51  THR n 
3 52  MET n 
3 53  ILE n 
3 54  PRO n 
3 55  PHE n 
3 56  ASP n 
3 57  LEU n 
3 58  SER n 
3 59  ALA n 
3 60  THR n 
3 61  LYS n 
3 62  LYS n 
3 63  ASN n 
3 64  THR n 
3 65  MET n 
3 66  GLU n 
3 67  MET n 
3 68  TYR n 
3 69  ARG n 
3 70  VAL n 
3 71  ARG n 
3 72  LEU n 
3 73  SER n 
3 74  ASP n 
3 75  LYS n 
3 76  PRO n 
3 77  HIS n 
3 78  THR n 
3 79  ASP n 
3 80  ASP n 
3 81  PRO n 
3 82  ILE n 
3 83  LEU n 
3 84  CYS n 
3 85  LEU n 
3 86  SER n 
3 87  LEU n 
3 88  SER n 
3 89  PRO n 
3 90  ALA n 
3 91  SER n 
3 92  ASP n 
3 93  PRO n 
3 94  ARG n 
3 95  LEU n 
3 96  SER n 
3 97  HIS n 
3 98  THR n 
3 99  MET n 
3 100 LEU n 
3 101 GLY n 
3 102 GLU n 
3 103 ILE n 
3 104 LEU n 
3 105 ASN n 
3 106 TYR n 
3 107 TYR n 
3 108 THR n 
3 109 HIS n 
3 110 TRP n 
3 111 ALA n 
3 112 GLY n 
3 113 SER n 
3 114 LEU n 
3 115 LYS n 
3 116 PHE n 
3 117 THR n 
3 118 PHE n 
3 119 MET n 
3 120 PHE n 
3 121 CYS n 
3 122 GLY n 
3 123 SER n 
3 124 MET n 
3 125 MET n 
3 126 ALA n 
3 127 THR n 
3 128 GLY n 
3 129 LYS n 
3 130 LEU n 
3 131 LEU n 
3 132 VAL n 
3 133 SER n 
3 134 TYR n 
3 135 ALA n 
3 136 PRO n 
3 137 PRO n 
3 138 GLY n 
3 139 ALA n 
3 140 ASP n 
3 141 PRO n 
3 142 PRO n 
3 143 LYS n 
3 144 LYS n 
3 145 ARG n 
3 146 LYS n 
3 147 GLU n 
3 148 ALA n 
3 149 MET n 
3 150 LEU n 
3 151 GLY n 
3 152 THR n 
3 153 HIS n 
3 154 VAL n 
3 155 ILE n 
3 156 TRP n 
3 157 ASP n 
3 158 ILE n 
3 159 GLY n 
3 160 LEU n 
3 161 GLN n 
3 162 SER n 
3 163 SER n 
3 164 CYS n 
3 165 THR n 
3 166 MET n 
3 167 VAL n 
3 168 VAL n 
3 169 PRO n 
3 170 TRP n 
3 171 ILE n 
3 172 SER n 
3 173 ASN n 
3 174 THR n 
3 175 THR n 
3 176 TYR n 
3 177 ARG n 
3 178 LEU n 
3 179 THR n 
3 180 ILE n 
3 181 ASP n 
3 182 ASP n 
3 183 SER n 
3 184 PHE n 
3 185 THR n 
3 186 GLU n 
3 187 GLY n 
3 188 GLY n 
3 189 TYR n 
3 190 ILE n 
3 191 SER n 
3 192 VAL n 
3 193 PHE n 
3 194 TYR n 
3 195 GLN n 
3 196 THR n 
3 197 ARG n 
3 198 ILE n 
3 199 VAL n 
3 200 VAL n 
3 201 PRO n 
3 202 LEU n 
3 203 SER n 
3 204 THR n 
3 205 PRO n 
3 206 ARG n 
3 207 GLU n 
3 208 MET n 
3 209 ASP n 
3 210 ILE n 
3 211 LEU n 
3 212 GLY n 
3 213 PHE n 
3 214 VAL n 
3 215 SER n 
3 216 ALA n 
3 217 CYS n 
3 218 ASN n 
3 219 ASP n 
3 220 PHE n 
3 221 SER n 
3 222 VAL n 
3 223 ARG n 
3 224 LEU n 
3 225 LEU n 
3 226 ARG n 
3 227 ASP n 
3 228 THR n 
3 229 THR n 
3 230 HIS n 
3 231 ILE n 
3 232 GLU n 
3 233 GLN n 
3 234 LYS n 
3 235 ALA n 
3 236 LEU n 
3 237 ALA n 
3 238 GLN n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 302 ? ? ? ? ? ? ? ? ? 'Human poliovirus 1 Mahoney' 12081 ? ? ? ? ? ? ? ? 'Mesocricetus auratus' 
10036 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 341 ? ? ? ? ? ? ? ? ? 'Human poliovirus 1 Mahoney' 12081 ? ? ? ? ? ? ? ? 'Mesocricetus auratus' 
10036 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 238 ? ? ? ? ? ? ? ? ? 'Human poliovirus 1 Mahoney' 12081 ? ? ? ? ? ? ? ? 'Mesocricetus auratus' 
10036 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   1   ?   ?   ?   A . n 
A 1 2   LEU 2   2   ?   ?   ?   A . n 
A 1 3   GLY 3   3   ?   ?   ?   A . n 
A 1 4   GLN 4   4   ?   ?   ?   A . n 
A 1 5   MET 5   5   ?   ?   ?   A . n 
A 1 6   LEU 6   6   ?   ?   ?   A . n 
A 1 7   GLU 7   7   ?   ?   ?   A . n 
A 1 8   SER 8   8   ?   ?   ?   A . n 
A 1 9   MET 9   9   ?   ?   ?   A . n 
A 1 10  ILE 10  10  ?   ?   ?   A . n 
A 1 11  ASP 11  11  ?   ?   ?   A . n 
A 1 12  ASN 12  12  ?   ?   ?   A . n 
A 1 13  THR 13  13  ?   ?   ?   A . n 
A 1 14  VAL 14  14  ?   ?   ?   A . n 
A 1 15  ARG 15  15  ?   ?   ?   A . n 
A 1 16  GLU 16  16  ?   ?   ?   A . n 
A 1 17  THR 17  17  ?   ?   ?   A . n 
A 1 18  VAL 18  18  ?   ?   ?   A . n 
A 1 19  GLY 19  19  ?   ?   ?   A . n 
A 1 20  ALA 20  20  ?   ?   ?   A . n 
A 1 21  ALA 21  21  ?   ?   ?   A . n 
A 1 22  THR 22  22  ?   ?   ?   A . n 
A 1 23  SER 23  23  ?   ?   ?   A . n 
A 1 24  ARG 24  24  ?   ?   ?   A . n 
A 1 25  ASP 25  25  ?   ?   ?   A . n 
A 1 26  ALA 26  26  ?   ?   ?   A . n 
A 1 27  LEU 27  27  ?   ?   ?   A . n 
A 1 28  PRO 28  28  ?   ?   ?   A . n 
A 1 29  ASN 29  29  ?   ?   ?   A . n 
A 1 30  THR 30  30  ?   ?   ?   A . n 
A 1 31  GLU 31  31  ?   ?   ?   A . n 
A 1 32  ALA 32  32  ?   ?   ?   A . n 
A 1 33  SER 33  33  ?   ?   ?   A . n 
A 1 34  GLY 34  34  ?   ?   ?   A . n 
A 1 35  PRO 35  35  ?   ?   ?   A . n 
A 1 36  THR 36  36  ?   ?   ?   A . n 
A 1 37  HIS 37  37  ?   ?   ?   A . n 
A 1 38  SER 38  38  ?   ?   ?   A . n 
A 1 39  LYS 39  39  ?   ?   ?   A . n 
A 1 40  GLU 40  40  ?   ?   ?   A . n 
A 1 41  ILE 41  41  ?   ?   ?   A . n 
A 1 42  PRO 42  42  ?   ?   ?   A . n 
A 1 43  ALA 43  43  ?   ?   ?   A . n 
A 1 44  LEU 44  44  ?   ?   ?   A . n 
A 1 45  THR 45  45  ?   ?   ?   A . n 
A 1 46  ALA 46  46  ?   ?   ?   A . n 
A 1 47  VAL 47  47  ?   ?   ?   A . n 
A 1 48  GLU 48  48  ?   ?   ?   A . n 
A 1 49  THR 49  49  ?   ?   ?   A . n 
A 1 50  GLY 50  50  ?   ?   ?   A . n 
A 1 51  ALA 51  51  ?   ?   ?   A . n 
A 1 52  THR 52  52  ?   ?   ?   A . n 
A 1 53  ASN 53  53  ?   ?   ?   A . n 
A 1 54  PRO 54  54  ?   ?   ?   A . n 
A 1 55  LEU 55  55  ?   ?   ?   A . n 
A 1 56  VAL 56  56  ?   ?   ?   A . n 
A 1 57  PRO 57  57  ?   ?   ?   A . n 
A 1 58  SER 58  58  ?   ?   ?   A . n 
A 1 59  ASP 59  59  ?   ?   ?   A . n 
A 1 60  THR 60  60  ?   ?   ?   A . n 
A 1 61  VAL 61  61  ?   ?   ?   A . n 
A 1 62  GLN 62  62  ?   ?   ?   A . n 
A 1 63  THR 63  63  ?   ?   ?   A . n 
A 1 64  ARG 64  64  ?   ?   ?   A . n 
A 1 65  HIS 65  65  ?   ?   ?   A . n 
A 1 66  VAL 66  66  ?   ?   ?   A . n 
A 1 67  VAL 67  67  ?   ?   ?   A . n 
A 1 68  GLN 68  68  68  GLN GLN A . n 
A 1 69  HIS 69  69  69  HIS HIS A . n 
A 1 70  ARG 70  70  70  ARG ARG A . n 
A 1 71  SER 71  71  71  SER SER A . n 
A 1 72  ARG 72  72  72  ARG ARG A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  GLU 74  74  74  GLU GLU A . n 
A 1 75  SER 75  75  75  SER SER A . n 
A 1 76  SER 76  76  76  SER SER A . n 
A 1 77  ILE 77  77  77  ILE ILE A . n 
A 1 78  GLU 78  78  78  GLU GLU A . n 
A 1 79  SER 79  79  79  SER SER A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  ARG 83  83  83  ARG ARG A . n 
A 1 84  GLY 84  84  84  GLY GLY A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  CYS 86  86  86  CYS CYS A . n 
A 1 87  VAL 87  87  87  VAL VAL A . n 
A 1 88  THR 88  88  88  THR THR A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  MET 90  90  90  MET MET A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  PRO 95  95  95  PRO PRO A . n 
A 1 96  ALA 96  96  96  ALA ALA A . n 
A 1 97  SER 97  97  97  SER SER A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  THR 99  99  99  THR THR A . n 
A 1 100 ASN 100 100 100 ASN ASN A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 ASP 102 102 102 ASP ASP A . n 
A 1 103 LYS 103 103 103 LYS LYS A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 PHE 105 105 105 PHE PHE A . n 
A 1 106 ALA 106 106 106 ALA ALA A . n 
A 1 107 VAL 107 107 107 VAL VAL A . n 
A 1 108 TRP 108 108 108 TRP TRP A . n 
A 1 109 LYS 109 109 109 LYS LYS A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 TYR 112 112 112 TYR TYR A . n 
A 1 113 LYS 113 113 113 LYS LYS A . n 
A 1 114 ASP 114 114 114 ASP ASP A . n 
A 1 115 THR 115 115 115 THR THR A . n 
A 1 116 VAL 116 116 116 VAL VAL A . n 
A 1 117 GLN 117 117 117 GLN GLN A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 ARG 119 119 119 ARG ARG A . n 
A 1 120 ARG 120 120 120 ARG ARG A . n 
A 1 121 LYS 121 121 121 LYS LYS A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 PHE 124 124 124 PHE PHE A . n 
A 1 125 PHE 125 125 125 PHE PHE A . n 
A 1 126 THR 126 126 126 THR THR A . n 
A 1 127 TYR 127 127 127 TYR TYR A . n 
A 1 128 SER 128 128 128 SER SER A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 PHE 130 130 130 PHE PHE A . n 
A 1 131 ASP 131 131 131 ASP ASP A . n 
A 1 132 MET 132 132 132 MET MET A . n 
A 1 133 GLU 133 133 133 GLU GLU A . n 
A 1 134 LEU 134 134 134 LEU LEU A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 PHE 136 136 136 PHE PHE A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 VAL 138 138 138 VAL VAL A . n 
A 1 139 THR 139 139 139 THR THR A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 ASN 141 141 141 ASN ASN A . n 
A 1 142 PHE 142 142 142 PHE PHE A . n 
A 1 143 THR 143 143 143 THR THR A . n 
A 1 144 GLU 144 144 144 GLU GLU A . n 
A 1 145 THR 145 145 145 THR THR A . n 
A 1 146 ASN 146 146 146 ASN ASN A . n 
A 1 147 ASN 147 147 147 ASN ASN A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 HIS 149 149 149 HIS HIS A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 ASN 152 152 152 ASN ASN A . n 
A 1 153 GLN 153 153 153 GLN GLN A . n 
A 1 154 VAL 154 154 154 VAL VAL A . n 
A 1 155 TYR 155 155 155 TYR TYR A . n 
A 1 156 GLN 156 156 156 GLN GLN A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 MET 158 158 158 MET MET A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 PRO 161 161 161 PRO PRO A . n 
A 1 162 PRO 162 162 162 PRO PRO A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 PRO 165 165 165 PRO PRO A . n 
A 1 166 VAL 166 166 166 VAL VAL A . n 
A 1 167 PRO 167 167 167 PRO PRO A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 LYS 169 169 169 LYS LYS A . n 
A 1 170 TRP 170 170 170 TRP TRP A . n 
A 1 171 ASP 171 171 171 ASP ASP A . n 
A 1 172 ASP 172 172 172 ASP ASP A . n 
A 1 173 TYR 173 173 173 TYR TYR A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 TRP 175 175 175 TRP TRP A . n 
A 1 176 GLN 176 176 176 GLN GLN A . n 
A 1 177 THR 177 177 177 THR THR A . n 
A 1 178 SER 178 178 178 SER SER A . n 
A 1 179 SER 179 179 179 SER SER A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PRO 181 181 181 PRO PRO A . n 
A 1 182 SER 182 182 182 SER SER A . n 
A 1 183 ILE 183 183 183 ILE ILE A . n 
A 1 184 PHE 184 184 184 PHE PHE A . n 
A 1 185 TYR 185 185 185 TYR TYR A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 TYR 187 187 187 TYR TYR A . n 
A 1 188 GLY 188 188 188 GLY GLY A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 PRO 191 191 191 PRO PRO A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 ARG 193 193 193 ARG ARG A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 PRO 197 197 197 PRO PRO A . n 
A 1 198 TYR 198 198 198 TYR TYR A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
A 1 200 GLY 200 200 200 GLY GLY A . n 
A 1 201 ILE 201 201 201 ILE ILE A . n 
A 1 202 SER 202 202 202 SER SER A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 TYR 205 205 205 TYR TYR A . n 
A 1 206 SER 206 206 206 SER SER A . n 
A 1 207 HIS 207 207 207 HIS HIS A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ASP 210 210 210 ASP ASP A . n 
A 1 211 GLY 211 211 211 GLY GLY A . n 
A 1 212 PHE 212 212 212 PHE PHE A . n 
A 1 213 SER 213 213 213 SER SER A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 VAL 215 215 215 VAL VAL A . n 
A 1 216 PRO 216 216 216 PRO PRO A . n 
A 1 217 LEU 217 217 ?   ?   ?   A . n 
A 1 218 LYS 218 218 ?   ?   ?   A . n 
A 1 219 ASP 219 219 ?   ?   ?   A . n 
A 1 220 GLN 220 220 ?   ?   ?   A . n 
A 1 221 SER 221 221 ?   ?   ?   A . n 
A 1 222 ALA 222 222 ?   ?   ?   A . n 
A 1 223 ALA 223 223 ?   ?   ?   A . n 
A 1 224 LEU 224 224 ?   ?   ?   A . n 
A 1 225 GLY 225 225 ?   ?   ?   A . n 
A 1 226 ASP 226 226 ?   ?   ?   A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 LEU 228 228 228 LEU LEU A . n 
A 1 229 TYR 229 229 229 TYR TYR A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 ALA 231 231 ?   ?   ?   A . n 
A 1 232 ALA 232 232 ?   ?   ?   A . n 
A 1 233 SER 233 233 233 SER SER A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ASN 235 235 235 ASN ASN A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 PHE 237 237 237 PHE PHE A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 ILE 239 239 239 ILE ILE A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 VAL 242 242 242 VAL VAL A . n 
A 1 243 ARG 243 243 243 ARG ARG A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 VAL 245 245 245 VAL VAL A . n 
A 1 246 ASN 246 246 246 ASN ASN A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 PRO 248 248 248 PRO PRO A . n 
A 1 249 ASN 249 249 249 ASN ASN A . n 
A 1 250 PRO 250 250 250 PRO PRO A . n 
A 1 251 THR 251 251 251 THR THR A . n 
A 1 252 LYS 252 252 252 LYS LYS A . n 
A 1 253 VAL 253 253 253 VAL VAL A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 LYS 256 256 256 LYS LYS A . n 
A 1 257 ILE 257 257 257 ILE ILE A . n 
A 1 258 ARG 258 258 258 ARG ARG A . n 
A 1 259 VAL 259 259 259 VAL VAL A . n 
A 1 260 TYR 260 260 260 TYR TYR A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 LYS 262 262 262 LYS LYS A . n 
A 1 263 PRO 263 263 263 PRO PRO A . n 
A 1 264 LYS 264 264 264 LYS LYS A . n 
A 1 265 HIS 265 265 265 HIS HIS A . n 
A 1 266 ILE 266 266 266 ILE ILE A . n 
A 1 267 ARG 267 267 267 ARG ARG A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 TRP 269 269 269 TRP TRP A . n 
A 1 270 CYS 270 270 270 CYS CYS A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 ARG 272 272 272 ARG ARG A . n 
A 1 273 PRO 273 273 273 PRO PRO A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 ARG 275 275 275 ARG ARG A . n 
A 1 276 ALA 276 276 276 ALA ALA A . n 
A 1 277 VAL 277 277 277 VAL VAL A . n 
A 1 278 ALA 278 278 278 ALA ALA A . n 
A 1 279 TYR 279 279 279 TYR TYR A . n 
A 1 280 TYR 280 280 280 TYR TYR A . n 
A 1 281 GLY 281 281 281 GLY GLY A . n 
A 1 282 PRO 282 282 282 PRO PRO A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 VAL 284 284 284 VAL VAL A . n 
A 1 285 ASP 285 285 285 ASP ASP A . n 
A 1 286 TYR 286 286 286 TYR TYR A . n 
A 1 287 LYS 287 287 ?   ?   ?   A . n 
A 1 288 ASP 288 288 ?   ?   ?   A . n 
A 1 289 GLY 289 289 ?   ?   ?   A . n 
A 1 290 THR 290 290 ?   ?   ?   A . n 
A 1 291 LEU 291 291 ?   ?   ?   A . n 
A 1 292 THR 292 292 ?   ?   ?   A . n 
A 1 293 PRO 293 293 ?   ?   ?   A . n 
A 1 294 LEU 294 294 ?   ?   ?   A . n 
A 1 295 SER 295 295 ?   ?   ?   A . n 
A 1 296 THR 296 296 ?   ?   ?   A . n 
A 1 297 LYS 297 297 ?   ?   ?   A . n 
A 1 298 ASP 298 298 ?   ?   ?   A . n 
A 1 299 LEU 299 299 ?   ?   ?   A . n 
A 1 300 THR 300 300 ?   ?   ?   A . n 
A 1 301 THR 301 301 ?   ?   ?   A . n 
A 1 302 TYR 302 302 ?   ?   ?   A . n 
B 2 1   MET 1   1   ?   ?   ?   B . n 
B 2 2   GLY 2   2   ?   ?   ?   B . n 
B 2 3   ALA 3   3   ?   ?   ?   B . n 
B 2 4   GLN 4   4   ?   ?   ?   B . n 
B 2 5   VAL 5   5   ?   ?   ?   B . n 
B 2 6   SER 6   6   ?   ?   ?   B . n 
B 2 7   SER 7   7   ?   ?   ?   B . n 
B 2 8   GLN 8   8   ?   ?   ?   B . n 
B 2 9   LYS 9   9   ?   ?   ?   B . n 
B 2 10  VAL 10  10  ?   ?   ?   B . n 
B 2 11  GLY 11  11  ?   ?   ?   B . n 
B 2 12  ALA 12  12  ?   ?   ?   B . n 
B 2 13  HIS 13  13  ?   ?   ?   B . n 
B 2 14  GLU 14  14  ?   ?   ?   B . n 
B 2 15  ASN 15  15  ?   ?   ?   B . n 
B 2 16  SER 16  16  ?   ?   ?   B . n 
B 2 17  ASN 17  17  ?   ?   ?   B . n 
B 2 18  GLY 18  18  ?   ?   ?   B . n 
B 2 19  ALA 19  19  ?   ?   ?   B . n 
B 2 20  TYR 20  20  ?   ?   ?   B . n 
B 2 21  GLY 21  21  ?   ?   ?   B . n 
B 2 22  GLY 22  22  ?   ?   ?   B . n 
B 2 23  SER 23  23  ?   ?   ?   B . n 
B 2 24  THR 24  24  ?   ?   ?   B . n 
B 2 25  ILE 25  25  ?   ?   ?   B . n 
B 2 26  ASN 26  26  ?   ?   ?   B . n 
B 2 27  TYR 27  27  ?   ?   ?   B . n 
B 2 28  THR 28  28  ?   ?   ?   B . n 
B 2 29  THR 29  29  ?   ?   ?   B . n 
B 2 30  ILE 30  30  ?   ?   ?   B . n 
B 2 31  ASN 31  31  ?   ?   ?   B . n 
B 2 32  TYR 32  32  32  TYR TYR B . n 
B 2 33  TYR 33  33  33  TYR TYR B . n 
B 2 34  ARG 34  34  34  ARG ARG B . n 
B 2 35  ASP 35  35  35  ASP ASP B . n 
B 2 36  SER 36  36  36  SER SER B . n 
B 2 37  ALA 37  37  37  ALA ALA B . n 
B 2 38  SER 38  38  38  SER SER B . n 
B 2 39  ASN 39  39  39  ASN ASN B . n 
B 2 40  ALA 40  40  40  ALA ALA B . n 
B 2 41  ALA 41  41  41  ALA ALA B . n 
B 2 42  SER 42  42  ?   ?   ?   B . n 
B 2 43  LYS 43  43  ?   ?   ?   B . n 
B 2 44  GLN 44  44  ?   ?   ?   B . n 
B 2 45  ASP 45  45  ?   ?   ?   B . n 
B 2 46  PHE 46  46  ?   ?   ?   B . n 
B 2 47  SER 47  47  ?   ?   ?   B . n 
B 2 48  GLN 48  48  ?   ?   ?   B . n 
B 2 49  ASP 49  49  ?   ?   ?   B . n 
B 2 50  PRO 50  50  ?   ?   ?   B . n 
B 2 51  SER 51  51  51  SER SER B . n 
B 2 52  LYS 52  52  52  LYS LYS B . n 
B 2 53  PHE 53  53  53  PHE PHE B . n 
B 2 54  THR 54  54  54  THR THR B . n 
B 2 55  GLU 55  55  55  GLU GLU B . n 
B 2 56  PRO 56  56  56  PRO PRO B . n 
B 2 57  ILE 57  57  57  ILE ILE B . n 
B 2 58  LYS 58  58  58  LYS LYS B . n 
B 2 59  ASP 59  59  59  ASP ASP B . n 
B 2 60  VAL 60  60  60  VAL VAL B . n 
B 2 61  LEU 61  61  61  LEU LEU B . n 
B 2 62  ILE 62  62  62  ILE ILE B . n 
B 2 63  LYS 63  63  63  LYS LYS B . n 
B 2 64  THR 64  64  64  THR THR B . n 
B 2 65  ALA 65  65  65  ALA ALA B . n 
B 2 66  PRO 66  66  66  PRO PRO B . n 
B 2 67  MET 67  67  67  MET MET B . n 
B 2 68  LEU 68  68  68  LEU LEU B . n 
B 2 69  ASN 69  69  69  ASN ASN B . n 
B 2 70  SER 70  70  ?   ?   ?   B . n 
B 2 71  PRO 71  71  ?   ?   ?   B . n 
B 2 72  ASN 72  72  ?   ?   ?   B . n 
B 2 73  ILE 73  73  ?   ?   ?   B . n 
B 2 74  GLU 74  74  ?   ?   ?   B . n 
B 2 75  ALA 75  75  ?   ?   ?   B . n 
B 2 76  CYS 76  76  ?   ?   ?   B . n 
B 2 77  GLY 77  77  ?   ?   ?   B . n 
B 2 78  TYR 78  78  ?   ?   ?   B . n 
B 2 79  SER 79  79  ?   ?   ?   B . n 
B 2 80  ASP 80  80  ?   ?   ?   B . n 
B 2 81  ARG 81  81  ?   ?   ?   B . n 
B 2 82  VAL 82  82  ?   ?   ?   B . n 
B 2 83  LEU 83  83  ?   ?   ?   B . n 
B 2 84  GLN 84  84  ?   ?   ?   B . n 
B 2 85  LEU 85  85  ?   ?   ?   B . n 
B 2 86  THR 86  86  ?   ?   ?   B . n 
B 2 87  LEU 87  87  ?   ?   ?   B . n 
B 2 88  GLY 88  88  ?   ?   ?   B . n 
B 2 89  ASN 89  89  ?   ?   ?   B . n 
B 2 90  SER 90  90  ?   ?   ?   B . n 
B 2 91  THR 91  91  91  THR THR B . n 
B 2 92  ILE 92  92  92  ILE ILE B . n 
B 2 93  THR 93  93  93  THR THR B . n 
B 2 94  ALA 94  94  94  ALA ALA B . n 
B 2 95  GLN 95  95  95  GLN GLN B . n 
B 2 96  GLU 96  96  96  GLU GLU B . n 
B 2 97  ALA 97  97  97  ALA ALA B . n 
B 2 98  ALA 98  98  98  ALA ALA B . n 
B 2 99  ASN 99  99  99  ASN ASN B . n 
B 2 100 SER 100 100 100 SER SER B . n 
B 2 101 VAL 101 101 101 VAL VAL B . n 
B 2 102 VAL 102 102 102 VAL VAL B . n 
B 2 103 ALA 103 103 103 ALA ALA B . n 
B 2 104 TYR 104 104 104 TYR TYR B . n 
B 2 105 GLY 105 105 105 GLY GLY B . n 
B 2 106 ARG 106 106 106 ARG ARG B . n 
B 2 107 TRP 107 107 107 TRP TRP B . n 
B 2 108 PRO 108 108 108 PRO PRO B . n 
B 2 109 GLU 109 109 109 GLU GLU B . n 
B 2 110 TYR 110 110 110 TYR TYR B . n 
B 2 111 LEU 111 111 111 LEU LEU B . n 
B 2 112 ARG 112 112 112 ARG ARG B . n 
B 2 113 ASP 113 113 113 ASP ASP B . n 
B 2 114 SER 114 114 ?   ?   ?   B . n 
B 2 115 GLU 115 115 ?   ?   ?   B . n 
B 2 116 ALA 116 116 ?   ?   ?   B . n 
B 2 117 ASN 117 117 ?   ?   ?   B . n 
B 2 118 PRO 118 118 ?   ?   ?   B . n 
B 2 119 VAL 119 119 ?   ?   ?   B . n 
B 2 120 ASP 120 120 ?   ?   ?   B . n 
B 2 121 GLN 121 121 ?   ?   ?   B . n 
B 2 122 PRO 122 122 ?   ?   ?   B . n 
B 2 123 THR 123 123 ?   ?   ?   B . n 
B 2 124 GLU 124 124 ?   ?   ?   B . n 
B 2 125 PRO 125 125 125 PRO PRO B . n 
B 2 126 GLU 126 126 126 GLU GLU B . n 
B 2 127 VAL 127 127 127 VAL VAL B . n 
B 2 128 ALA 128 128 128 ALA ALA B . n 
B 2 129 ALA 129 129 129 ALA ALA B . n 
B 2 130 CYS 130 130 130 CYS CYS B . n 
B 2 131 ARG 131 131 131 ARG ARG B . n 
B 2 132 PHE 132 132 132 PHE PHE B . n 
B 2 133 TYR 133 133 133 TYR TYR B . n 
B 2 134 THR 134 134 134 THR THR B . n 
B 2 135 LEU 135 135 135 LEU LEU B . n 
B 2 136 ASP 136 136 136 ASP ASP B . n 
B 2 137 THR 137 137 137 THR THR B . n 
B 2 138 VAL 138 138 138 VAL VAL B . n 
B 2 139 SER 139 139 139 SER SER B . n 
B 2 140 TRP 140 140 140 TRP TRP B . n 
B 2 141 THR 141 141 141 THR THR B . n 
B 2 142 LYS 142 142 142 LYS LYS B . n 
B 2 143 GLU 143 143 143 GLU GLU B . n 
B 2 144 SER 144 144 144 SER SER B . n 
B 2 145 ARG 145 145 145 ARG ARG B . n 
B 2 146 GLY 146 146 146 GLY GLY B . n 
B 2 147 TRP 147 147 147 TRP TRP B . n 
B 2 148 TRP 148 148 148 TRP TRP B . n 
B 2 149 TRP 149 149 149 TRP TRP B . n 
B 2 150 LYS 150 150 150 LYS LYS B . n 
B 2 151 LEU 151 151 151 LEU LEU B . n 
B 2 152 PRO 152 152 152 PRO PRO B . n 
B 2 153 ASP 153 153 153 ASP ASP B . n 
B 2 154 ALA 154 154 154 ALA ALA B . n 
B 2 155 LEU 155 155 155 LEU LEU B . n 
B 2 156 ARG 156 156 156 ARG ARG B . n 
B 2 157 ASP 157 157 157 ASP ASP B . n 
B 2 158 MET 158 158 158 MET MET B . n 
B 2 159 GLY 159 159 159 GLY GLY B . n 
B 2 160 LEU 160 160 160 LEU LEU B . n 
B 2 161 PHE 161 161 161 PHE PHE B . n 
B 2 162 GLY 162 162 162 GLY GLY B . n 
B 2 163 GLN 163 163 163 GLN GLN B . n 
B 2 164 ASN 164 164 164 ASN ASN B . n 
B 2 165 MET 165 165 165 MET MET B . n 
B 2 166 TYR 166 166 166 TYR TYR B . n 
B 2 167 TYR 167 167 167 TYR TYR B . n 
B 2 168 HIS 168 168 168 HIS HIS B . n 
B 2 169 TYR 169 169 169 TYR TYR B . n 
B 2 170 LEU 170 170 170 LEU LEU B . n 
B 2 171 GLY 171 171 171 GLY GLY B . n 
B 2 172 ARG 172 172 172 ARG ARG B . n 
B 2 173 SER 173 173 173 SER SER B . n 
B 2 174 GLY 174 174 174 GLY GLY B . n 
B 2 175 TYR 175 175 175 TYR TYR B . n 
B 2 176 THR 176 176 176 THR THR B . n 
B 2 177 VAL 177 177 177 VAL VAL B . n 
B 2 178 HIS 178 178 178 HIS HIS B . n 
B 2 179 VAL 179 179 179 VAL VAL B . n 
B 2 180 GLN 180 180 180 GLN GLN B . n 
B 2 181 CYS 181 181 181 CYS CYS B . n 
B 2 182 ASN 182 182 182 ASN ASN B . n 
B 2 183 ALA 183 183 183 ALA ALA B . n 
B 2 184 SER 184 184 184 SER SER B . n 
B 2 185 LYS 185 185 185 LYS LYS B . n 
B 2 186 PHE 186 186 186 PHE PHE B . n 
B 2 187 HIS 187 187 187 HIS HIS B . n 
B 2 188 GLN 188 188 188 GLN GLN B . n 
B 2 189 GLY 189 189 189 GLY GLY B . n 
B 2 190 ALA 190 190 190 ALA ALA B . n 
B 2 191 LEU 191 191 191 LEU LEU B . n 
B 2 192 GLY 192 192 192 GLY GLY B . n 
B 2 193 VAL 193 193 193 VAL VAL B . n 
B 2 194 PHE 194 194 194 PHE PHE B . n 
B 2 195 ALA 195 195 195 ALA ALA B . n 
B 2 196 VAL 196 196 196 VAL VAL B . n 
B 2 197 PRO 197 197 197 PRO PRO B . n 
B 2 198 GLU 198 198 198 GLU GLU B . n 
B 2 199 MET 199 199 199 MET MET B . n 
B 2 200 CYS 200 200 200 CYS CYS B . n 
B 2 201 LEU 201 201 201 LEU LEU B . n 
B 2 202 ALA 202 202 202 ALA ALA B . n 
B 2 203 GLY 203 203 203 GLY GLY B . n 
B 2 204 ASP 204 204 204 ASP ASP B . n 
B 2 205 SER 205 205 205 SER SER B . n 
B 2 206 ASN 206 206 ?   ?   ?   B . n 
B 2 207 THR 207 207 ?   ?   ?   B . n 
B 2 208 THR 208 208 ?   ?   ?   B . n 
B 2 209 THR 209 209 ?   ?   ?   B . n 
B 2 210 MET 210 210 ?   ?   ?   B . n 
B 2 211 HIS 211 211 ?   ?   ?   B . n 
B 2 212 THR 212 212 212 THR THR B . n 
B 2 213 SER 213 213 213 SER SER B . n 
B 2 214 TYR 214 214 214 TYR TYR B . n 
B 2 215 GLN 215 215 215 GLN GLN B . n 
B 2 216 ASN 216 216 216 ASN ASN B . n 
B 2 217 ALA 217 217 217 ALA ALA B . n 
B 2 218 ASN 218 218 218 ASN ASN B . n 
B 2 219 PRO 219 219 219 PRO PRO B . n 
B 2 220 GLY 220 220 220 GLY GLY B . n 
B 2 221 GLU 221 221 221 GLU GLU B . n 
B 2 222 LYS 222 222 222 LYS LYS B . n 
B 2 223 GLY 223 223 223 GLY GLY B . n 
B 2 224 GLY 224 224 224 GLY GLY B . n 
B 2 225 THR 225 225 225 THR THR B . n 
B 2 226 PHE 226 226 226 PHE PHE B . n 
B 2 227 THR 227 227 227 THR THR B . n 
B 2 228 GLY 228 228 228 GLY GLY B . n 
B 2 229 THR 229 229 229 THR THR B . n 
B 2 230 PHE 230 230 ?   ?   ?   B . n 
B 2 231 THR 231 231 ?   ?   ?   B . n 
B 2 232 PRO 232 232 ?   ?   ?   B . n 
B 2 233 ASP 233 233 ?   ?   ?   B . n 
B 2 234 ASN 234 234 ?   ?   ?   B . n 
B 2 235 ASN 235 235 ?   ?   ?   B . n 
B 2 236 GLN 236 236 ?   ?   ?   B . n 
B 2 237 THR 237 237 ?   ?   ?   B . n 
B 2 238 SER 238 238 ?   ?   ?   B . n 
B 2 239 PRO 239 239 ?   ?   ?   B . n 
B 2 240 ALA 240 240 ?   ?   ?   B . n 
B 2 241 ARG 241 241 ?   ?   ?   B . n 
B 2 242 ARG 242 242 242 ARG ARG B . n 
B 2 243 PHE 243 243 243 PHE PHE B . n 
B 2 244 CYS 244 244 244 CYS CYS B . n 
B 2 245 PRO 245 245 245 PRO PRO B . n 
B 2 246 VAL 246 246 246 VAL VAL B . n 
B 2 247 ASP 247 247 247 ASP ASP B . n 
B 2 248 TYR 248 248 248 TYR TYR B . n 
B 2 249 LEU 249 249 249 LEU LEU B . n 
B 2 250 LEU 250 250 250 LEU LEU B . n 
B 2 251 GLY 251 251 251 GLY GLY B . n 
B 2 252 ASN 252 252 252 ASN ASN B . n 
B 2 253 GLY 253 253 253 GLY GLY B . n 
B 2 254 THR 254 254 254 THR THR B . n 
B 2 255 LEU 255 255 255 LEU LEU B . n 
B 2 256 LEU 256 256 256 LEU LEU B . n 
B 2 257 GLY 257 257 257 GLY GLY B . n 
B 2 258 ASN 258 258 258 ASN ASN B . n 
B 2 259 ALA 259 259 259 ALA ALA B . n 
B 2 260 PHE 260 260 260 PHE PHE B . n 
B 2 261 VAL 261 261 261 VAL VAL B . n 
B 2 262 PHE 262 262 262 PHE PHE B . n 
B 2 263 PRO 263 263 263 PRO PRO B . n 
B 2 264 HIS 264 264 264 HIS HIS B . n 
B 2 265 GLN 265 265 265 GLN GLN B . n 
B 2 266 ILE 266 266 266 ILE ILE B . n 
B 2 267 ILE 267 267 267 ILE ILE B . n 
B 2 268 ASN 268 268 268 ASN ASN B . n 
B 2 269 LEU 269 269 269 LEU LEU B . n 
B 2 270 ARG 270 270 270 ARG ARG B . n 
B 2 271 THR 271 271 271 THR THR B . n 
B 2 272 ASN 272 272 272 ASN ASN B . n 
B 2 273 ASN 273 273 273 ASN ASN B . n 
B 2 274 CYS 274 274 274 CYS CYS B . n 
B 2 275 ALA 275 275 275 ALA ALA B . n 
B 2 276 THR 276 276 276 THR THR B . n 
B 2 277 LEU 277 277 277 LEU LEU B . n 
B 2 278 VAL 278 278 278 VAL VAL B . n 
B 2 279 LEU 279 279 279 LEU LEU B . n 
B 2 280 PRO 280 280 280 PRO PRO B . n 
B 2 281 TYR 281 281 281 TYR TYR B . n 
B 2 282 VAL 282 282 282 VAL VAL B . n 
B 2 283 ASN 283 283 283 ASN ASN B . n 
B 2 284 SER 284 284 284 SER SER B . n 
B 2 285 LEU 285 285 285 LEU LEU B . n 
B 2 286 SER 286 286 286 SER SER B . n 
B 2 287 ILE 287 287 287 ILE ILE B . n 
B 2 288 ASP 288 288 288 ASP ASP B . n 
B 2 289 SER 289 289 289 SER SER B . n 
B 2 290 MET 290 290 290 MET MET B . n 
B 2 291 VAL 291 291 291 VAL VAL B . n 
B 2 292 LYS 292 292 292 LYS LYS B . n 
B 2 293 HIS 293 293 293 HIS HIS B . n 
B 2 294 ASN 294 294 294 ASN ASN B . n 
B 2 295 ASN 295 295 295 ASN ASN B . n 
B 2 296 TRP 296 296 296 TRP TRP B . n 
B 2 297 GLY 297 297 297 GLY GLY B . n 
B 2 298 ILE 298 298 298 ILE ILE B . n 
B 2 299 ALA 299 299 299 ALA ALA B . n 
B 2 300 ILE 300 300 300 ILE ILE B . n 
B 2 301 LEU 301 301 301 LEU LEU B . n 
B 2 302 PRO 302 302 302 PRO PRO B . n 
B 2 303 LEU 303 303 303 LEU LEU B . n 
B 2 304 ALA 304 304 304 ALA ALA B . n 
B 2 305 PRO 305 305 305 PRO PRO B . n 
B 2 306 LEU 306 306 306 LEU LEU B . n 
B 2 307 ASN 307 307 307 ASN ASN B . n 
B 2 308 PHE 308 308 308 PHE PHE B . n 
B 2 309 ALA 309 309 309 ALA ALA B . n 
B 2 310 SER 310 310 310 SER SER B . n 
B 2 311 GLU 311 311 311 GLU GLU B . n 
B 2 312 SER 312 312 312 SER SER B . n 
B 2 313 SER 313 313 313 SER SER B . n 
B 2 314 PRO 314 314 314 PRO PRO B . n 
B 2 315 GLU 315 315 315 GLU GLU B . n 
B 2 316 ILE 316 316 316 ILE ILE B . n 
B 2 317 PRO 317 317 317 PRO PRO B . n 
B 2 318 ILE 318 318 318 ILE ILE B . n 
B 2 319 THR 319 319 319 THR THR B . n 
B 2 320 LEU 320 320 320 LEU LEU B . n 
B 2 321 THR 321 321 321 THR THR B . n 
B 2 322 ILE 322 322 322 ILE ILE B . n 
B 2 323 ALA 323 323 323 ALA ALA B . n 
B 2 324 PRO 324 324 324 PRO PRO B . n 
B 2 325 MET 325 325 325 MET MET B . n 
B 2 326 CYS 326 326 326 CYS CYS B . n 
B 2 327 CYS 327 327 327 CYS CYS B . n 
B 2 328 GLU 328 328 328 GLU GLU B . n 
B 2 329 PHE 329 329 329 PHE PHE B . n 
B 2 330 ASN 330 330 330 ASN ASN B . n 
B 2 331 GLY 331 331 331 GLY GLY B . n 
B 2 332 LEU 332 332 332 LEU LEU B . n 
B 2 333 ARG 333 333 333 ARG ARG B . n 
B 2 334 ASN 334 334 334 ASN ASN B . n 
B 2 335 ILE 335 335 335 ILE ILE B . n 
B 2 336 THR 336 336 ?   ?   ?   B . n 
B 2 337 LEU 337 337 ?   ?   ?   B . n 
B 2 338 PRO 338 338 ?   ?   ?   B . n 
B 2 339 ARG 339 339 ?   ?   ?   B . n 
B 2 340 LEU 340 340 ?   ?   ?   B . n 
B 2 341 GLN 341 341 ?   ?   ?   B . n 
C 3 1   GLY 1   1   1   GLY GLY C . n 
C 3 2   LEU 2   2   2   LEU LEU C . n 
C 3 3   PRO 3   3   3   PRO PRO C . n 
C 3 4   VAL 4   4   4   VAL VAL C . n 
C 3 5   MET 5   5   5   MET MET C . n 
C 3 6   ASN 6   6   6   ASN ASN C . n 
C 3 7   THR 7   7   7   THR THR C . n 
C 3 8   PRO 8   8   8   PRO PRO C . n 
C 3 9   GLY 9   9   9   GLY GLY C . n 
C 3 10  SER 10  10  10  SER SER C . n 
C 3 11  ASN 11  11  11  ASN ASN C . n 
C 3 12  GLN 12  12  12  GLN GLN C . n 
C 3 13  TYR 13  13  13  TYR TYR C . n 
C 3 14  LEU 14  14  14  LEU LEU C . n 
C 3 15  THR 15  15  15  THR THR C . n 
C 3 16  ALA 16  16  16  ALA ALA C . n 
C 3 17  ASP 17  17  17  ASP ASP C . n 
C 3 18  ASN 18  18  18  ASN ASN C . n 
C 3 19  PHE 19  19  19  PHE PHE C . n 
C 3 20  GLN 20  20  20  GLN GLN C . n 
C 3 21  SER 21  21  21  SER SER C . n 
C 3 22  PRO 22  22  22  PRO PRO C . n 
C 3 23  CYS 23  23  23  CYS CYS C . n 
C 3 24  ALA 24  24  24  ALA ALA C . n 
C 3 25  LEU 25  25  25  LEU LEU C . n 
C 3 26  PRO 26  26  26  PRO PRO C . n 
C 3 27  GLU 27  27  27  GLU GLU C . n 
C 3 28  PHE 28  28  28  PHE PHE C . n 
C 3 29  ASP 29  29  29  ASP ASP C . n 
C 3 30  VAL 30  30  30  VAL VAL C . n 
C 3 31  THR 31  31  31  THR THR C . n 
C 3 32  PRO 32  32  32  PRO PRO C . n 
C 3 33  PRO 33  33  33  PRO PRO C . n 
C 3 34  ILE 34  34  34  ILE ILE C . n 
C 3 35  ASP 35  35  35  ASP ASP C . n 
C 3 36  ILE 36  36  36  ILE ILE C . n 
C 3 37  PRO 37  37  37  PRO PRO C . n 
C 3 38  GLY 38  38  38  GLY GLY C . n 
C 3 39  GLU 39  39  39  GLU GLU C . n 
C 3 40  VAL 40  40  40  VAL VAL C . n 
C 3 41  LYS 41  41  41  LYS LYS C . n 
C 3 42  ASN 42  42  42  ASN ASN C . n 
C 3 43  MET 43  43  43  MET MET C . n 
C 3 44  MET 44  44  44  MET MET C . n 
C 3 45  GLU 45  45  45  GLU GLU C . n 
C 3 46  LEU 46  46  46  LEU LEU C . n 
C 3 47  ALA 47  47  47  ALA ALA C . n 
C 3 48  GLU 48  48  48  GLU GLU C . n 
C 3 49  ILE 49  49  49  ILE ILE C . n 
C 3 50  ASP 50  50  50  ASP ASP C . n 
C 3 51  THR 51  51  51  THR THR C . n 
C 3 52  MET 52  52  52  MET MET C . n 
C 3 53  ILE 53  53  53  ILE ILE C . n 
C 3 54  PRO 54  54  54  PRO PRO C . n 
C 3 55  PHE 55  55  55  PHE PHE C . n 
C 3 56  ASP 56  56  56  ASP ASP C . n 
C 3 57  LEU 57  57  57  LEU LEU C . n 
C 3 58  SER 58  58  58  SER SER C . n 
C 3 59  ALA 59  59  59  ALA ALA C . n 
C 3 60  THR 60  60  60  THR THR C . n 
C 3 61  LYS 61  61  61  LYS LYS C . n 
C 3 62  LYS 62  62  62  LYS LYS C . n 
C 3 63  ASN 63  63  63  ASN ASN C . n 
C 3 64  THR 64  64  64  THR THR C . n 
C 3 65  MET 65  65  65  MET MET C . n 
C 3 66  GLU 66  66  66  GLU GLU C . n 
C 3 67  MET 67  67  67  MET MET C . n 
C 3 68  TYR 68  68  68  TYR TYR C . n 
C 3 69  ARG 69  69  69  ARG ARG C . n 
C 3 70  VAL 70  70  70  VAL VAL C . n 
C 3 71  ARG 71  71  71  ARG ARG C . n 
C 3 72  LEU 72  72  72  LEU LEU C . n 
C 3 73  SER 73  73  73  SER SER C . n 
C 3 74  ASP 74  74  74  ASP ASP C . n 
C 3 75  LYS 75  75  75  LYS LYS C . n 
C 3 76  PRO 76  76  76  PRO PRO C . n 
C 3 77  HIS 77  77  77  HIS HIS C . n 
C 3 78  THR 78  78  78  THR THR C . n 
C 3 79  ASP 79  79  79  ASP ASP C . n 
C 3 80  ASP 80  80  80  ASP ASP C . n 
C 3 81  PRO 81  81  81  PRO PRO C . n 
C 3 82  ILE 82  82  82  ILE ILE C . n 
C 3 83  LEU 83  83  83  LEU LEU C . n 
C 3 84  CYS 84  84  84  CYS CYS C . n 
C 3 85  LEU 85  85  85  LEU LEU C . n 
C 3 86  SER 86  86  86  SER SER C . n 
C 3 87  LEU 87  87  87  LEU LEU C . n 
C 3 88  SER 88  88  88  SER SER C . n 
C 3 89  PRO 89  89  89  PRO PRO C . n 
C 3 90  ALA 90  90  90  ALA ALA C . n 
C 3 91  SER 91  91  91  SER SER C . n 
C 3 92  ASP 92  92  92  ASP ASP C . n 
C 3 93  PRO 93  93  93  PRO PRO C . n 
C 3 94  ARG 94  94  94  ARG ARG C . n 
C 3 95  LEU 95  95  95  LEU LEU C . n 
C 3 96  SER 96  96  96  SER SER C . n 
C 3 97  HIS 97  97  97  HIS HIS C . n 
C 3 98  THR 98  98  98  THR THR C . n 
C 3 99  MET 99  99  99  MET MET C . n 
C 3 100 LEU 100 100 100 LEU LEU C . n 
C 3 101 GLY 101 101 101 GLY GLY C . n 
C 3 102 GLU 102 102 102 GLU GLU C . n 
C 3 103 ILE 103 103 103 ILE ILE C . n 
C 3 104 LEU 104 104 104 LEU LEU C . n 
C 3 105 ASN 105 105 105 ASN ASN C . n 
C 3 106 TYR 106 106 106 TYR TYR C . n 
C 3 107 TYR 107 107 107 TYR TYR C . n 
C 3 108 THR 108 108 108 THR THR C . n 
C 3 109 HIS 109 109 109 HIS HIS C . n 
C 3 110 TRP 110 110 110 TRP TRP C . n 
C 3 111 ALA 111 111 111 ALA ALA C . n 
C 3 112 GLY 112 112 112 GLY GLY C . n 
C 3 113 SER 113 113 113 SER SER C . n 
C 3 114 LEU 114 114 114 LEU LEU C . n 
C 3 115 LYS 115 115 115 LYS LYS C . n 
C 3 116 PHE 116 116 116 PHE PHE C . n 
C 3 117 THR 117 117 117 THR THR C . n 
C 3 118 PHE 118 118 118 PHE PHE C . n 
C 3 119 MET 119 119 119 MET MET C . n 
C 3 120 PHE 120 120 120 PHE PHE C . n 
C 3 121 CYS 121 121 121 CYS CYS C . n 
C 3 122 GLY 122 122 122 GLY GLY C . n 
C 3 123 SER 123 123 123 SER SER C . n 
C 3 124 MET 124 124 124 MET MET C . n 
C 3 125 MET 125 125 125 MET MET C . n 
C 3 126 ALA 126 126 126 ALA ALA C . n 
C 3 127 THR 127 127 127 THR THR C . n 
C 3 128 GLY 128 128 128 GLY GLY C . n 
C 3 129 LYS 129 129 129 LYS LYS C . n 
C 3 130 LEU 130 130 130 LEU LEU C . n 
C 3 131 LEU 131 131 131 LEU LEU C . n 
C 3 132 VAL 132 132 132 VAL VAL C . n 
C 3 133 SER 133 133 133 SER SER C . n 
C 3 134 TYR 134 134 134 TYR TYR C . n 
C 3 135 ALA 135 135 135 ALA ALA C . n 
C 3 136 PRO 136 136 136 PRO PRO C . n 
C 3 137 PRO 137 137 137 PRO PRO C . n 
C 3 138 GLY 138 138 138 GLY GLY C . n 
C 3 139 ALA 139 139 139 ALA ALA C . n 
C 3 140 ASP 140 140 140 ASP ASP C . n 
C 3 141 PRO 141 141 141 PRO PRO C . n 
C 3 142 PRO 142 142 142 PRO PRO C . n 
C 3 143 LYS 143 143 143 LYS LYS C . n 
C 3 144 LYS 144 144 144 LYS LYS C . n 
C 3 145 ARG 145 145 145 ARG ARG C . n 
C 3 146 LYS 146 146 146 LYS LYS C . n 
C 3 147 GLU 147 147 147 GLU GLU C . n 
C 3 148 ALA 148 148 148 ALA ALA C . n 
C 3 149 MET 149 149 149 MET MET C . n 
C 3 150 LEU 150 150 150 LEU LEU C . n 
C 3 151 GLY 151 151 151 GLY GLY C . n 
C 3 152 THR 152 152 152 THR THR C . n 
C 3 153 HIS 153 153 153 HIS HIS C . n 
C 3 154 VAL 154 154 154 VAL VAL C . n 
C 3 155 ILE 155 155 155 ILE ILE C . n 
C 3 156 TRP 156 156 156 TRP TRP C . n 
C 3 157 ASP 157 157 157 ASP ASP C . n 
C 3 158 ILE 158 158 158 ILE ILE C . n 
C 3 159 GLY 159 159 159 GLY GLY C . n 
C 3 160 LEU 160 160 160 LEU LEU C . n 
C 3 161 GLN 161 161 161 GLN GLN C . n 
C 3 162 SER 162 162 162 SER SER C . n 
C 3 163 SER 163 163 163 SER SER C . n 
C 3 164 CYS 164 164 164 CYS CYS C . n 
C 3 165 THR 165 165 165 THR THR C . n 
C 3 166 MET 166 166 166 MET MET C . n 
C 3 167 VAL 167 167 167 VAL VAL C . n 
C 3 168 VAL 168 168 168 VAL VAL C . n 
C 3 169 PRO 169 169 169 PRO PRO C . n 
C 3 170 TRP 170 170 170 TRP TRP C . n 
C 3 171 ILE 171 171 171 ILE ILE C . n 
C 3 172 SER 172 172 172 SER SER C . n 
C 3 173 ASN 173 173 173 ASN ASN C . n 
C 3 174 THR 174 174 174 THR THR C . n 
C 3 175 THR 175 175 175 THR THR C . n 
C 3 176 TYR 176 176 176 TYR TYR C . n 
C 3 177 ARG 177 177 177 ARG ARG C . n 
C 3 178 LEU 178 178 178 LEU LEU C . n 
C 3 179 THR 179 179 179 THR THR C . n 
C 3 180 ILE 180 180 180 ILE ILE C . n 
C 3 181 ASP 181 181 181 ASP ASP C . n 
C 3 182 ASP 182 182 182 ASP ASP C . n 
C 3 183 SER 183 183 183 SER SER C . n 
C 3 184 PHE 184 184 184 PHE PHE C . n 
C 3 185 THR 185 185 185 THR THR C . n 
C 3 186 GLU 186 186 186 GLU GLU C . n 
C 3 187 GLY 187 187 187 GLY GLY C . n 
C 3 188 GLY 188 188 188 GLY GLY C . n 
C 3 189 TYR 189 189 189 TYR TYR C . n 
C 3 190 ILE 190 190 190 ILE ILE C . n 
C 3 191 SER 191 191 191 SER SER C . n 
C 3 192 VAL 192 192 192 VAL VAL C . n 
C 3 193 PHE 193 193 193 PHE PHE C . n 
C 3 194 TYR 194 194 194 TYR TYR C . n 
C 3 195 GLN 195 195 195 GLN GLN C . n 
C 3 196 THR 196 196 196 THR THR C . n 
C 3 197 ARG 197 197 197 ARG ARG C . n 
C 3 198 ILE 198 198 198 ILE ILE C . n 
C 3 199 VAL 199 199 199 VAL VAL C . n 
C 3 200 VAL 200 200 200 VAL VAL C . n 
C 3 201 PRO 201 201 201 PRO PRO C . n 
C 3 202 LEU 202 202 202 LEU LEU C . n 
C 3 203 SER 203 203 203 SER SER C . n 
C 3 204 THR 204 204 204 THR THR C . n 
C 3 205 PRO 205 205 205 PRO PRO C . n 
C 3 206 ARG 206 206 206 ARG ARG C . n 
C 3 207 GLU 207 207 207 GLU GLU C . n 
C 3 208 MET 208 208 208 MET MET C . n 
C 3 209 ASP 209 209 209 ASP ASP C . n 
C 3 210 ILE 210 210 210 ILE ILE C . n 
C 3 211 LEU 211 211 211 LEU LEU C . n 
C 3 212 GLY 212 212 212 GLY GLY C . n 
C 3 213 PHE 213 213 213 PHE PHE C . n 
C 3 214 VAL 214 214 214 VAL VAL C . n 
C 3 215 SER 215 215 215 SER SER C . n 
C 3 216 ALA 216 216 216 ALA ALA C . n 
C 3 217 CYS 217 217 217 CYS CYS C . n 
C 3 218 ASN 218 218 218 ASN ASN C . n 
C 3 219 ASP 219 219 219 ASP ASP C . n 
C 3 220 PHE 220 220 220 PHE PHE C . n 
C 3 221 SER 221 221 221 SER SER C . n 
C 3 222 VAL 222 222 222 VAL VAL C . n 
C 3 223 ARG 223 223 223 ARG ARG C . n 
C 3 224 LEU 224 224 224 LEU LEU C . n 
C 3 225 LEU 225 225 225 LEU LEU C . n 
C 3 226 ARG 226 226 226 ARG ARG C . n 
C 3 227 ASP 227 227 227 ASP ASP C . n 
C 3 228 THR 228 228 228 THR THR C . n 
C 3 229 THR 229 229 229 THR THR C . n 
C 3 230 HIS 230 230 230 HIS HIS C . n 
C 3 231 ILE 231 231 231 ILE ILE C . n 
C 3 232 GLU 232 232 232 GLU GLU C . n 
C 3 233 GLN 233 233 233 GLN GLN C . n 
C 3 234 LYS 234 234 ?   ?   ?   C . n 
C 3 235 ALA 235 235 ?   ?   ?   C . n 
C 3 236 LEU 236 236 ?   ?   ?   C . n 
C 3 237 ALA 237 237 ?   ?   ?   C . n 
C 3 238 GLN 238 238 ?   ?   ?   C . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9F0K 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9F0K 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9F0K 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9F0K 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.005  ? 33300 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.529  ? 45354 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 11.295 ? 12006 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.045  ? 5016  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004  ? 5784  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9F0K 
_struct.title                        
;Poliovirus type 1 (strain Mahoney) expanded conformation stabilised virus-like particle (PV1 SC6b) from a mammalian expression system
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9F0K 
_struct_keywords.text            'Capsid protein, vaccine, VIRUS LIKE PARTICLE' 
_struct_keywords.pdbx_keywords   'VIRUS LIKE PARTICLE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP POLG_POL1M P03300 ? 1 
;GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESF
FARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYV
PPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGIL
AVRVVNDHNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY
;
580 
2 UNP POLG_POL1M P03300 ? 2 
;GAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSDR
VLQLTLGNSTITTQEAANSVVAYGRWPEYLRDSEANPVDQPTEPDVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGLF
GQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPAR
RFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITLT
IAPMCCEFNGLRNITLPRLQ
;
2   
3 UNP POLG_POL1M P03300 ? 3 
;GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDD
PILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFLFCGFMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRQTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQ
;
342 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9F0K A 1 ? 302 ? P03300 580 ? 881 ? 1 302 
2 2 9F0K B 2 ? 341 ? P03300 2   ? 341 ? 2 341 
3 3 9F0K C 1 ? 238 ? P03300 342 ? 579 ? 1 238 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9F0K PRO A 248 ? UNP P03300 HIS 827 'engineered mutation'   248 1 
2 9F0K MET B 1   ? UNP P03300 ?   ?   'initiating methionine' 1   2 
2 9F0K GLY B 18  ? UNP P03300 ARG 18  'engineered mutation'   18  3 
2 9F0K ALA B 94  ? UNP P03300 THR 94  'engineered mutation'   94  4 
2 9F0K GLU B 126 ? UNP P03300 ASP 126 'engineered mutation'   126 5 
3 9F0K MET C 119 ? UNP P03300 LEU 460 'engineered mutation'   119 6 
3 9F0K SER C 123 ? UNP P03300 PHE 464 conflict                123 7 
3 9F0K LEU C 178 ? UNP P03300 GLN 519 conflict                178 8 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   180-meric 
_pdbx_struct_assembly.oligomeric_count     180 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   
;1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60
;
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1  'identity operation'       1_555 x,y,z 1.000000  0.000000  0.000000  0.00000    0.000000  1.000000  0.000000  0.00000    
0.000000  0.000000  1.000000  0.00000    
2  'point symmetry operation' ?     ?     -0.809017 -0.500000 0.309017  431.36957  -0.500000 0.309017  -0.809017 431.72109  
0.309017  -0.809017 -0.500000 431.93834  
3  'point symmetry operation' ?     ?     0.000000  1.000000  0.000000  -0.26290   0.000000  0.000000  -1.000000 431.85380  
-1.000000 0.000000  0.000000  431.59090  
4  'point symmetry operation' ?     ?     0.809017  -0.500000 -0.309017 215.87543  -0.500000 -0.309017 -0.809017 565.16921  
0.309017  0.809017  -0.500000 82.56662   
5  'point symmetry operation' ?     ?     0.500000  0.309017  -0.809017 215.79749  -0.309017 -0.809017 -0.500000 565.21738  
-0.809017 0.500000  -0.309017 349.16767  
6  'point symmetry operation' ?     ?     -0.309017 -0.809017 -0.500000 564.95448  -0.809017 0.500000  -0.309017 349.16107  
0.500000  0.309017  -0.809017 216.06699  
7  'point symmetry operation' ?     ?     -0.809017 0.500000  -0.309017 348.89817  0.500000  0.309017  -0.809017 216.06039  
-0.309017 -0.809017 -0.500000 565.22398  
8  'point symmetry operation' ?     ?     -0.809017 -0.500000 -0.309017 564.82177  0.500000  -0.309017 -0.809017 349.50851  
0.309017  -0.809017 0.500000  216.00814  
9  'point symmetry operation' ?     ?     -0.309017 0.809017  -0.500000 215.58276  -0.809017 -0.500000 -0.309017 565.08467  
-0.500000 0.309017  0.809017  82.34529   
10 'point symmetry operation' ?     ?     0.500000  -0.309017 -0.809017 349.24561  -0.309017 0.809017  -0.500000 215.84566  
0.809017  0.500000  0.309017  -133.23087 
11 'point symmetry operation' ?     ?     0.000000  0.000000  -1.000000 431.59090  -1.000000 0.000000  0.000000  431.58430  
0.000000  1.000000  0.000000  0.00660    
12 'point symmetry operation' ?     ?     -0.500000 -0.309017 -0.809017 564.90631  0.309017  0.809017  -0.500000 82.56002   
0.809017  -0.500000 -0.309017 216.14493  
13 'point symmetry operation' ?     ?     -0.500000 0.309017  -0.809017 431.45819  0.309017  -0.809017 -0.500000 431.93174  
-0.809017 -0.500000 0.309017  431.63907  
14 'point symmetry operation' ?     ?     -0.309017 -0.809017 -0.500000 564.95448  0.809017  -0.500000 0.309017  82.68613   
-0.500000 -0.309017 0.809017  215.79341  
15 'point symmetry operation' ?     ?     -0.809017 0.500000  -0.309017 348.89817  -0.500000 -0.309017 0.809017  215.78681  
0.309017  0.809017  0.500000  -133.36358 
16 'point symmetry operation' ?     ?     0.500000  0.309017  -0.809017 215.79749  0.309017  0.809017  0.500000  -133.37018 
0.809017  -0.500000 0.309017  82.69273   
17 'point symmetry operation' ?     ?     -0.500000 0.309017  -0.809017 431.45819  -0.309017 0.809017  0.500000  -0.08454   
0.809017  0.500000  -0.309017 0.22133    
18 'point symmetry operation' ?     ?     0.000000  0.000000  -1.000000 431.59090  1.000000  0.000000  0.000000  0.26290    
0.000000  -1.000000 0.000000  431.85380  
19 'point symmetry operation' ?     ?     -0.500000 -0.309017 -0.809017 564.90631  -0.309017 -0.809017 0.500000  349.28718  
-0.809017 0.500000  0.309017  215.71547  
20 'point symmetry operation' ?     ?     0.000000  -1.000000 0.000000  431.58430  0.000000  0.000000  1.000000  -0.00660   
-1.000000 0.000000  0.000000  431.59090  
21 'point symmetry operation' ?     ?     -0.809017 0.500000  0.309017  215.44597  0.500000  0.309017  0.809017  -133.32201 
0.309017  0.809017  -0.500000 82.56662   
22 'point symmetry operation' ?     ?     0.809017  0.500000  -0.309017 -0.04817   0.500000  -0.309017 0.809017  0.12611    
0.309017  -0.809017 -0.500000 431.93834  
23 'point symmetry operation' ?     ?     -0.309017 0.809017  -0.500000 215.58276  0.809017  0.500000  0.309017  -133.23747 
0.500000  -0.309017 -0.809017 349.51511  
24 'point symmetry operation' ?     ?     0.500000  -0.309017 -0.809017 349.24561  0.309017  -0.809017 0.500000  216.00154  
-0.809017 -0.500000 -0.309017 565.09127  
25 'point symmetry operation' ?     ?     -0.809017 -0.500000 -0.309017 564.82177  -0.500000 0.309017  0.809017  82.33869   
-0.309017 0.809017  -0.500000 215.85226  
26 'point symmetry operation' ?     ?     -0.309017 -0.809017 0.500000  349.02428  -0.809017 0.500000  0.309017  215.70887  
-0.500000 -0.309017 -0.809017 565.17581  
27 'point symmetry operation' ?     ?     -0.309017 0.809017  0.500000  -0.34744   0.809017  0.500000  -0.309017 0.21473    
-0.500000 0.309017  -0.809017 431.72769  
28 'point symmetry operation' ?     ?     1.000000  0.000000  0.000000  0.00000    0.000000  -1.000000 0.000000  431.84720  
0.000000  0.000000  -1.000000 431.86040  
29 'point symmetry operation' ?     ?     0.309017  0.809017  -0.500000 82.29712   0.809017  -0.500000 -0.309017 216.13833  
-0.500000 -0.309017 -0.809017 565.17581  
30 'point symmetry operation' ?     ?     0.309017  -0.809017 -0.500000 431.66884  -0.809017 -0.500000 0.309017  431.63247  
-0.500000 0.309017  -0.809017 431.72769  
31 'point symmetry operation' ?     ?     -1.000000 0.000000  0.000000  431.32140  0.000000  1.000000  0.000000  0.00000    
0.000000  0.000000  -1.000000 431.86040  
32 'point symmetry operation' ?     ?     0.809017  0.500000  -0.309017 -0.04817   -0.500000 0.309017  -0.809017 431.72109  
-0.309017 0.809017  0.500000  -0.07794   
33 'point symmetry operation' ?     ?     0.000000  -1.000000 0.000000  431.58430  0.000000  0.000000  -1.000000 431.85380  
1.000000  0.000000  0.000000  0.26950    
34 'point symmetry operation' ?     ?     -0.809017 0.500000  0.309017  215.44597  -0.500000 -0.309017 -0.809017 565.16921  
-0.309017 -0.809017 0.500000  349.29378  
35 'point symmetry operation' ?     ?     -0.500000 -0.309017 0.809017  215.52391  -0.309017 -0.809017 -0.500000 565.21738  
0.809017  -0.500000 0.309017  82.69273   
36 'point symmetry operation' ?     ?     0.309017  0.809017  0.500000  -133.63308 -0.809017 0.500000  -0.309017 349.16107  
-0.500000 -0.309017 0.809017  215.79341  
37 'point symmetry operation' ?     ?     0.809017  -0.500000 0.309017  82.42323   0.500000  0.309017  -0.809017 216.06039  
0.309017  0.809017  0.500000  -133.36358 
38 'point symmetry operation' ?     ?     0.809017  0.500000  0.309017  -133.50037 0.500000  -0.309017 -0.809017 349.50851  
-0.309017 0.809017  -0.500000 215.85226  
39 'point symmetry operation' ?     ?     0.309017  -0.809017 0.500000  215.73864  -0.809017 -0.500000 -0.309017 565.08467  
0.500000  -0.309017 -0.809017 349.51511  
40 'point symmetry operation' ?     ?     -0.500000 0.309017  0.809017  82.07579   -0.309017 0.809017  -0.500000 215.84566  
-0.809017 -0.500000 -0.309017 565.09127  
41 'point symmetry operation' ?     ?     0.000000  0.000000  1.000000  -0.26950   -1.000000 0.000000  0.000000  431.58430  
0.000000  -1.000000 0.000000  431.85380  
42 'point symmetry operation' ?     ?     0.500000  0.309017  0.809017  -133.58491 0.309017  0.809017  -0.500000 82.56002   
-0.809017 0.500000  0.309017  215.71547  
43 'point symmetry operation' ?     ?     0.500000  -0.309017 0.809017  -0.13679   0.309017  -0.809017 -0.500000 431.93174  
0.809017  0.500000  -0.309017 0.22133    
44 'point symmetry operation' ?     ?     0.309017  0.809017  0.500000  -133.63308 0.809017  -0.500000 0.309017  82.68613   
0.500000  0.309017  -0.809017 216.06699  
45 'point symmetry operation' ?     ?     0.809017  -0.500000 0.309017  82.42323   -0.500000 -0.309017 0.809017  215.78681  
-0.309017 -0.809017 -0.500000 565.22398  
46 'point symmetry operation' ?     ?     -0.500000 -0.309017 0.809017  215.52391  0.309017  0.809017  0.500000  -133.37018 
-0.809017 0.500000  -0.309017 349.16767  
47 'point symmetry operation' ?     ?     0.500000  -0.309017 0.809017  -0.13679   -0.309017 0.809017  0.500000  -0.08454   
-0.809017 -0.500000 0.309017  431.63907  
48 'point symmetry operation' ?     ?     0.000000  0.000000  1.000000  -0.26950   1.000000  0.000000  0.000000  0.26290    
0.000000  1.000000  0.000000  0.00660    
49 'point symmetry operation' ?     ?     0.500000  0.309017  0.809017  -133.58491 -0.309017 -0.809017 0.500000  349.28718  
0.809017  -0.500000 -0.309017 216.14493  
50 'point symmetry operation' ?     ?     0.000000  1.000000  0.000000  -0.26290   0.000000  0.000000  1.000000  -0.00660   
1.000000  0.000000  0.000000  0.26950    
51 'point symmetry operation' ?     ?     0.809017  -0.500000 -0.309017 215.87543  0.500000  0.309017  0.809017  -133.32201 
-0.309017 -0.809017 0.500000  349.29378  
52 'point symmetry operation' ?     ?     -0.809017 -0.500000 0.309017  431.36957  0.500000  -0.309017 0.809017  0.12611    
-0.309017 0.809017  0.500000  -0.07794   
53 'point symmetry operation' ?     ?     0.309017  -0.809017 0.500000  215.73864  0.809017  0.500000  0.309017  -133.23747 
-0.500000 0.309017  0.809017  82.34529   
54 'point symmetry operation' ?     ?     -0.500000 0.309017  0.809017  82.07579   0.309017  -0.809017 0.500000  216.00154  
0.809017  0.500000  0.309017  -133.23087 
55 'point symmetry operation' ?     ?     0.809017  0.500000  0.309017  -133.50037 -0.500000 0.309017  0.809017  82.33869   
0.309017  -0.809017 0.500000  216.00814  
56 'point symmetry operation' ?     ?     0.309017  0.809017  -0.500000 82.29712   -0.809017 0.500000  0.309017  215.70887  
0.500000  0.309017  0.809017  -133.31541 
57 'point symmetry operation' ?     ?     0.309017  -0.809017 -0.500000 431.66884  0.809017  0.500000  -0.309017 0.21473    
0.500000  -0.309017 0.809017  0.13271    
58 'point symmetry operation' ?     ?     -1.000000 0.000000  0.000000  431.32140  0.000000  -1.000000 0.000000  431.84720  
0.000000  0.000000  1.000000  0.00000    
59 'point symmetry operation' ?     ?     -0.309017 -0.809017 0.500000  349.02428  0.809017  -0.500000 -0.309017 216.13833  
0.500000  0.309017  0.809017  -133.31541 
60 'point symmetry operation' ?     ?     -0.309017 0.809017  0.500000  -0.34744   -0.809017 -0.500000 0.309017  431.63247  
0.500000  -0.309017 0.809017  0.13271    
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 76  ? ALA A 82  ? SER A 76  ALA A 82  1 ? 7  
HELX_P HELX_P2  AA2 THR A 115 ? GLU A 123 ? THR A 115 GLU A 123 1 ? 9  
HELX_P HELX_P3  AA3 ASP A 172 ? GLN A 176 ? ASP A 172 GLN A 176 5 ? 5  
HELX_P HELX_P4  AA4 ILE B 57  ? ILE B 62  ? ILE B 57  ILE B 62  1 ? 6  
HELX_P HELX_P5  AA5 GLU B 96  ? SER B 100 ? GLU B 96  SER B 100 5 ? 5  
HELX_P HELX_P6  AA6 TYR B 104 ? ARG B 106 ? TYR B 104 ARG B 106 5 ? 3  
HELX_P HELX_P7  AA7 VAL B 127 ? ARG B 131 ? VAL B 127 ARG B 131 5 ? 5  
HELX_P HELX_P8  AA8 PRO B 152 ? ARG B 156 ? PRO B 152 ARG B 156 5 ? 5  
HELX_P HELX_P9  AA9 MET B 158 ? TYR B 167 ? MET B 158 TYR B 167 1 ? 10 
HELX_P HELX_P10 AB1 SER B 213 ? ASN B 218 ? SER B 213 ASN B 218 1 ? 6  
HELX_P HELX_P11 AB2 PRO B 219 ? GLY B 223 ? PRO B 219 GLY B 223 5 ? 5  
HELX_P HELX_P12 AB3 LEU B 256 ? PHE B 262 ? LEU B 256 PHE B 262 5 ? 7  
HELX_P HELX_P13 AB4 MET C 65  ? ARG C 69  ? MET C 65  ARG C 69  5 ? 5  
HELX_P HELX_P14 AB5 THR C 98  ? ASN C 105 ? THR C 98  ASN C 105 1 ? 8  
HELX_P HELX_P15 AB6 LYS C 144 ? LEU C 150 ? LYS C 144 LEU C 150 1 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LEU 
_struct_mon_prot_cis.label_seq_id           151 
_struct_mon_prot_cis.label_asym_id          B 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LEU 
_struct_mon_prot_cis.auth_seq_id            151 
_struct_mon_prot_cis.auth_asym_id           B 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    152 
_struct_mon_prot_cis.pdbx_label_asym_id_2   B 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     152 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    B 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       8.39 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 5 ? 
AA5 ? 5 ? 
AA6 ? 4 ? 
AA7 ? 3 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
AB1 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? parallel      
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 85  ? ASN A 94  ? ALA A 85  ASN A 94  
AA1 2 VAL A 253 ? TRP A 269 ? VAL A 253 TRP A 269 
AA1 3 TYR A 127 ? PHE A 142 ? TYR A 127 PHE A 142 
AA1 4 TYR A 205 ? SER A 206 ? TYR A 205 SER A 206 
AA2 1 ALA A 192 ? VAL A 196 ? ALA A 192 VAL A 196 
AA2 2 TYR A 127 ? PHE A 142 ? TYR A 127 PHE A 142 
AA2 3 VAL A 253 ? TRP A 269 ? VAL A 253 TRP A 269 
AA2 4 GLU C 39  ? VAL C 40  ? GLU C 39  VAL C 40  
AA3 1 ALA A 106 ? LYS A 109 ? ALA A 106 LYS A 109 
AA3 2 ILE A 239 ? VAL A 244 ? ILE A 239 VAL A 244 
AA3 3 VAL A 154 ? VAL A 160 ? VAL A 154 VAL A 160 
AA3 4 SER A 182 ? THR A 186 ? SER A 182 THR A 186 
AA4 1 VAL B 101 ? VAL B 102 ? VAL B 101 VAL B 102 
AA4 2 CYS B 274 ? LEU B 279 ? CYS B 274 LEU B 279 
AA4 3 LEU B 170 ? CYS B 181 ? LEU B 170 CYS B 181 
AA4 4 ILE B 316 ? ASN B 330 ? ILE B 316 ASN B 330 
AA4 5 TYR B 133 ? THR B 134 ? TYR B 133 THR B 134 
AA5 1 VAL B 101 ? VAL B 102 ? VAL B 101 VAL B 102 
AA5 2 CYS B 274 ? LEU B 279 ? CYS B 274 LEU B 279 
AA5 3 LEU B 170 ? CYS B 181 ? LEU B 170 CYS B 181 
AA5 4 ILE B 316 ? ASN B 330 ? ILE B 316 ASN B 330 
AA5 5 VAL B 138 ? TRP B 140 ? VAL B 138 TRP B 140 
AA6 1 TRP B 147 ? LEU B 151 ? TRP B 147 LEU B 151 
AA6 2 TRP B 296 ? PHE B 308 ? TRP B 296 PHE B 308 
AA6 3 HIS B 187 ? PRO B 197 ? HIS B 187 PRO B 197 
AA6 4 HIS B 264 ? ASN B 268 ? HIS B 264 ASN B 268 
AA7 1 THR C 51  ? MET C 52  ? THR C 51  MET C 52  
AA7 2 MET C 208 ? ALA C 216 ? MET C 208 ALA C 216 
AA7 3 VAL C 70  ? LEU C 72  ? VAL C 70  LEU C 72  
AA8 1 THR C 51  ? MET C 52  ? THR C 51  MET C 52  
AA8 2 MET C 208 ? ALA C 216 ? MET C 208 ALA C 216 
AA8 3 LEU C 114 ? PHE C 120 ? LEU C 114 PHE C 120 
AA8 4 SER C 163 ? VAL C 168 ? SER C 163 VAL C 168 
AA9 1 LEU C 83  ? SER C 86  ? LEU C 83  SER C 86  
AA9 2 TYR C 189 ? TYR C 194 ? TYR C 189 TYR C 194 
AA9 3 GLY C 128 ? ALA C 135 ? GLY C 128 ALA C 135 
AA9 4 THR C 152 ? ILE C 158 ? THR C 152 ILE C 158 
AB1 1 ARG C 177 ? LEU C 178 ? ARG C 177 LEU C 178 
AB1 2 HIS C 109 ? ALA C 111 ? HIS C 109 ALA C 111 
AB1 3 SER C 221 ? ARG C 223 ? SER C 221 ARG C 223 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N MET A 90  ? N MET A 90  O ILE A 257 ? O ILE A 257 
AA1 2 3 O TYR A 260 ? O TYR A 260 N THR A 135 ? N THR A 135 
AA1 3 4 N SER A 128 ? N SER A 128 O TYR A 205 ? O TYR A 205 
AA2 1 2 O VAL A 196 ? O VAL A 196 N MET A 132 ? N MET A 132 
AA2 2 3 N THR A 135 ? N THR A 135 O TYR A 260 ? O TYR A 260 
AA2 3 4 N VAL A 268 ? N VAL A 268 O VAL C 40  ? O VAL C 40  
AA3 1 2 N ALA A 106 ? N ALA A 106 O VAL A 242 ? O VAL A 242 
AA3 2 3 O ALA A 241 ? O ALA A 241 N MET A 158 ? N MET A 158 
AA3 3 4 N TYR A 155 ? N TYR A 155 O TYR A 185 ? O TYR A 185 
AA4 1 2 N VAL B 101 ? N VAL B 101 O VAL B 278 ? O VAL B 278 
AA4 2 3 O LEU B 277 ? O LEU B 277 N VAL B 177 ? N VAL B 177 
AA4 3 4 N LEU B 170 ? N LEU B 170 O ASN B 330 ? O ASN B 330 
AA4 4 5 O ILE B 322 ? O ILE B 322 N TYR B 133 ? N TYR B 133 
AA5 1 2 N VAL B 101 ? N VAL B 101 O VAL B 278 ? O VAL B 278 
AA5 2 3 O LEU B 277 ? O LEU B 277 N VAL B 177 ? N VAL B 177 
AA5 3 4 N LEU B 170 ? N LEU B 170 O ASN B 330 ? O ASN B 330 
AA5 4 5 O ILE B 316 ? O ILE B 316 N TRP B 140 ? N TRP B 140 
AA6 1 2 N TRP B 147 ? N TRP B 147 O ILE B 300 ? O ILE B 300 
AA6 2 3 O ASN B 307 ? O ASN B 307 N GLN B 188 ? N GLN B 188 
AA6 3 4 N VAL B 193 ? N VAL B 193 O GLN B 265 ? O GLN B 265 
AA7 1 2 N THR C 51  ? N THR C 51  O VAL C 214 ? O VAL C 214 
AA7 2 3 O MET C 208 ? O MET C 208 N LEU C 72  ? N LEU C 72  
AA8 1 2 N THR C 51  ? N THR C 51  O VAL C 214 ? O VAL C 214 
AA8 2 3 O LEU C 211 ? O LEU C 211 N MET C 119 ? N MET C 119 
AA8 3 4 N PHE C 116 ? N PHE C 116 O MET C 166 ? O MET C 166 
AA9 1 2 N LEU C 85  ? N LEU C 85  O ILE C 190 ? O ILE C 190 
AA9 2 3 O PHE C 193 ? O PHE C 193 N LEU C 131 ? N LEU C 131 
AA9 3 4 N VAL C 132 ? N VAL C 132 O VAL C 154 ? O VAL C 154 
AB1 1 2 O ARG C 177 ? O ARG C 177 N TRP C 110 ? N TRP C 110 
AB1 2 3 N HIS C 109 ? N HIS C 109 O ARG C 223 ? O ARG C 223 
# 
_pdbx_entry_details.entry_id                   9F0K 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 TRP A 175 ? ? -87.37  41.19   
2  1 GLN A 176 ? ? -141.42 -23.14  
3  1 CYS A 270 ? ? 53.40   76.69   
4  1 TYR A 280 ? ? 58.59   -144.77 
5  1 SER B 36  ? ? -97.04  33.51   
6  1 THR B 54  ? ? -92.57  59.78   
7  1 GLU B 55  ? ? 45.10   72.72   
8  1 LEU B 61  ? ? -95.14  -60.11  
9  1 PRO B 66  ? ? -85.11  46.21   
10 1 GLN B 95  ? ? 76.06   -7.94   
11 1 TYR B 104 ? ? 55.11   18.09   
12 1 PRO B 245 ? ? -59.24  177.23  
13 1 THR C 15  ? ? -68.82  4.78    
14 1 PRO C 26  ? ? -64.68  -179.56 
15 1 LYS C 61  ? ? -103.43 59.91   
16 1 SER C 172 ? ? -170.45 149.05  
17 1 SER C 183 ? ? 79.59   -1.61   
18 1 GLU C 186 ? ? -147.90 -155.51 
19 1 LEU C 202 ? ? -148.16 -157.94 
20 1 SER C 203 ? ? -60.17  1.06    
21 1 THR C 204 ? ? -38.96  135.60  
22 1 LEU C 224 ? ? 62.11   70.12   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9F0K 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   'Cross-correlation coefficient' 
_em_3d_fitting.details           
;Initial model was rigid body fitted using UCSF chimera and Coot.  Global minimization and B-factor refinement 
was performed in real space using phenix_real.space.refine.
;
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'RIGID BODY FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  1HXS 
_em_3d_fitting_list.pdb_chain_id                  ? 
_em_3d_fitting_list.pdb_chain_residue_range       ? 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                1HXS 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    9F0K 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'BACK PROJECTION' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.0 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               6252 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          3 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       '1 x DPBS, 20 mM EDTA, pH 7.0' 
_em_buffer.pH            7.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 VIRUS 
_em_entity_assembly.name                 'Human poliovirus 1 Mahoney' 
_em_entity_assembly.details              'Recombinantly expressed virus-like particle of poliovirus type 1 (Mahoney strain).' 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3' 
# 
_em_image_scans.entry_id                9F0K 
_em_image_scans.id                      1 
_em_image_scans.number_digital_images   ? 
_em_image_scans.details                 ? 
_em_image_scans.scanner_model           ? 
_em_image_scans.sampling_size           14.0 
_em_image_scans.od_range                ? 
_em_image_scans.quant_bit_size          ? 
_em_image_scans.citation_id             ? 
_em_image_scans.dimension_height        ? 
_em_image_scans.dimension_width         ? 
_em_image_scans.frames_per_image        30 
_em_image_scans.image_recording_id      1 
_em_image_scans.used_frames_per_image   1-30 
# 
_em_imaging.entry_id                        9F0K 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         'Preliminary grid screening was performed on a Glacios 200 kV microscope.' 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'DARK FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2900 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           75000 
_em_imaging.calibrated_magnification        129629 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            100 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   400 
_em_sample_support.grid_type        'EMS Lacey Carbon' 
_em_sample_support.details          
'The exact grid type was the ULtra-thin carbon support film, 3nm - on lacey carbon. Product code AGS187-4 from Agar Scientific.' 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_virus_entity.id                    1 
_em_virus_entity.virus_host_category   ? 
_em_virus_entity.virus_type            'VIRUS-LIKE PARTICLE' 
_em_virus_entity.virus_isolate         SEROTYPE 
_em_virus_entity.entity_assembly_id    1 
_em_virus_entity.enveloped             NO 
_em_virus_entity.empty                 YES 
_em_virus_entity.details               ? 
# 
_em_vitrification.entry_id              9F0K 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE-PROPANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               
'3-4 ul of sample double blotted for 3.5 seconds with -15 blot force on FEI Vitrobot mark IV.' 
# 
_em_experiment.entry_id                9F0K 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9F0K 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        I 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY 1   ? A GLY 1   
2   1 Y 1 A LEU 2   ? A LEU 2   
3   1 Y 1 A GLY 3   ? A GLY 3   
4   1 Y 1 A GLN 4   ? A GLN 4   
5   1 Y 1 A MET 5   ? A MET 5   
6   1 Y 1 A LEU 6   ? A LEU 6   
7   1 Y 1 A GLU 7   ? A GLU 7   
8   1 Y 1 A SER 8   ? A SER 8   
9   1 Y 1 A MET 9   ? A MET 9   
10  1 Y 1 A ILE 10  ? A ILE 10  
11  1 Y 1 A ASP 11  ? A ASP 11  
12  1 Y 1 A ASN 12  ? A ASN 12  
13  1 Y 1 A THR 13  ? A THR 13  
14  1 Y 1 A VAL 14  ? A VAL 14  
15  1 Y 1 A ARG 15  ? A ARG 15  
16  1 Y 1 A GLU 16  ? A GLU 16  
17  1 Y 1 A THR 17  ? A THR 17  
18  1 Y 1 A VAL 18  ? A VAL 18  
19  1 Y 1 A GLY 19  ? A GLY 19  
20  1 Y 1 A ALA 20  ? A ALA 20  
21  1 Y 1 A ALA 21  ? A ALA 21  
22  1 Y 1 A THR 22  ? A THR 22  
23  1 Y 1 A SER 23  ? A SER 23  
24  1 Y 1 A ARG 24  ? A ARG 24  
25  1 Y 1 A ASP 25  ? A ASP 25  
26  1 Y 1 A ALA 26  ? A ALA 26  
27  1 Y 1 A LEU 27  ? A LEU 27  
28  1 Y 1 A PRO 28  ? A PRO 28  
29  1 Y 1 A ASN 29  ? A ASN 29  
30  1 Y 1 A THR 30  ? A THR 30  
31  1 Y 1 A GLU 31  ? A GLU 31  
32  1 Y 1 A ALA 32  ? A ALA 32  
33  1 Y 1 A SER 33  ? A SER 33  
34  1 Y 1 A GLY 34  ? A GLY 34  
35  1 Y 1 A PRO 35  ? A PRO 35  
36  1 Y 1 A THR 36  ? A THR 36  
37  1 Y 1 A HIS 37  ? A HIS 37  
38  1 Y 1 A SER 38  ? A SER 38  
39  1 Y 1 A LYS 39  ? A LYS 39  
40  1 Y 1 A GLU 40  ? A GLU 40  
41  1 Y 1 A ILE 41  ? A ILE 41  
42  1 Y 1 A PRO 42  ? A PRO 42  
43  1 Y 1 A ALA 43  ? A ALA 43  
44  1 Y 1 A LEU 44  ? A LEU 44  
45  1 Y 1 A THR 45  ? A THR 45  
46  1 Y 1 A ALA 46  ? A ALA 46  
47  1 Y 1 A VAL 47  ? A VAL 47  
48  1 Y 1 A GLU 48  ? A GLU 48  
49  1 Y 1 A THR 49  ? A THR 49  
50  1 Y 1 A GLY 50  ? A GLY 50  
51  1 Y 1 A ALA 51  ? A ALA 51  
52  1 Y 1 A THR 52  ? A THR 52  
53  1 Y 1 A ASN 53  ? A ASN 53  
54  1 Y 1 A PRO 54  ? A PRO 54  
55  1 Y 1 A LEU 55  ? A LEU 55  
56  1 Y 1 A VAL 56  ? A VAL 56  
57  1 Y 1 A PRO 57  ? A PRO 57  
58  1 Y 1 A SER 58  ? A SER 58  
59  1 Y 1 A ASP 59  ? A ASP 59  
60  1 Y 1 A THR 60  ? A THR 60  
61  1 Y 1 A VAL 61  ? A VAL 61  
62  1 Y 1 A GLN 62  ? A GLN 62  
63  1 Y 1 A THR 63  ? A THR 63  
64  1 Y 1 A ARG 64  ? A ARG 64  
65  1 Y 1 A HIS 65  ? A HIS 65  
66  1 Y 1 A VAL 66  ? A VAL 66  
67  1 Y 1 A VAL 67  ? A VAL 67  
68  1 Y 1 A LEU 217 ? A LEU 217 
69  1 Y 1 A LYS 218 ? A LYS 218 
70  1 Y 1 A ASP 219 ? A ASP 219 
71  1 Y 1 A GLN 220 ? A GLN 220 
72  1 Y 1 A SER 221 ? A SER 221 
73  1 Y 1 A ALA 222 ? A ALA 222 
74  1 Y 1 A ALA 223 ? A ALA 223 
75  1 Y 1 A LEU 224 ? A LEU 224 
76  1 Y 1 A GLY 225 ? A GLY 225 
77  1 Y 1 A ASP 226 ? A ASP 226 
78  1 Y 1 A ALA 231 ? A ALA 231 
79  1 Y 1 A ALA 232 ? A ALA 232 
80  1 Y 1 A LYS 287 ? A LYS 287 
81  1 Y 1 A ASP 288 ? A ASP 288 
82  1 Y 1 A GLY 289 ? A GLY 289 
83  1 Y 1 A THR 290 ? A THR 290 
84  1 Y 1 A LEU 291 ? A LEU 291 
85  1 Y 1 A THR 292 ? A THR 292 
86  1 Y 1 A PRO 293 ? A PRO 293 
87  1 Y 1 A LEU 294 ? A LEU 294 
88  1 Y 1 A SER 295 ? A SER 295 
89  1 Y 1 A THR 296 ? A THR 296 
90  1 Y 1 A LYS 297 ? A LYS 297 
91  1 Y 1 A ASP 298 ? A ASP 298 
92  1 Y 1 A LEU 299 ? A LEU 299 
93  1 Y 1 A THR 300 ? A THR 300 
94  1 Y 1 A THR 301 ? A THR 301 
95  1 Y 1 A TYR 302 ? A TYR 302 
96  1 Y 1 B MET 1   ? B MET 1   
97  1 Y 1 B GLY 2   ? B GLY 2   
98  1 Y 1 B ALA 3   ? B ALA 3   
99  1 Y 1 B GLN 4   ? B GLN 4   
100 1 Y 1 B VAL 5   ? B VAL 5   
101 1 Y 1 B SER 6   ? B SER 6   
102 1 Y 1 B SER 7   ? B SER 7   
103 1 Y 1 B GLN 8   ? B GLN 8   
104 1 Y 1 B LYS 9   ? B LYS 9   
105 1 Y 1 B VAL 10  ? B VAL 10  
106 1 Y 1 B GLY 11  ? B GLY 11  
107 1 Y 1 B ALA 12  ? B ALA 12  
108 1 Y 1 B HIS 13  ? B HIS 13  
109 1 Y 1 B GLU 14  ? B GLU 14  
110 1 Y 1 B ASN 15  ? B ASN 15  
111 1 Y 1 B SER 16  ? B SER 16  
112 1 Y 1 B ASN 17  ? B ASN 17  
113 1 Y 1 B GLY 18  ? B GLY 18  
114 1 Y 1 B ALA 19  ? B ALA 19  
115 1 Y 1 B TYR 20  ? B TYR 20  
116 1 Y 1 B GLY 21  ? B GLY 21  
117 1 Y 1 B GLY 22  ? B GLY 22  
118 1 Y 1 B SER 23  ? B SER 23  
119 1 Y 1 B THR 24  ? B THR 24  
120 1 Y 1 B ILE 25  ? B ILE 25  
121 1 Y 1 B ASN 26  ? B ASN 26  
122 1 Y 1 B TYR 27  ? B TYR 27  
123 1 Y 1 B THR 28  ? B THR 28  
124 1 Y 1 B THR 29  ? B THR 29  
125 1 Y 1 B ILE 30  ? B ILE 30  
126 1 Y 1 B ASN 31  ? B ASN 31  
127 1 Y 1 B SER 42  ? B SER 42  
128 1 Y 1 B LYS 43  ? B LYS 43  
129 1 Y 1 B GLN 44  ? B GLN 44  
130 1 Y 1 B ASP 45  ? B ASP 45  
131 1 Y 1 B PHE 46  ? B PHE 46  
132 1 Y 1 B SER 47  ? B SER 47  
133 1 Y 1 B GLN 48  ? B GLN 48  
134 1 Y 1 B ASP 49  ? B ASP 49  
135 1 Y 1 B PRO 50  ? B PRO 50  
136 1 Y 1 B SER 70  ? B SER 70  
137 1 Y 1 B PRO 71  ? B PRO 71  
138 1 Y 1 B ASN 72  ? B ASN 72  
139 1 Y 1 B ILE 73  ? B ILE 73  
140 1 Y 1 B GLU 74  ? B GLU 74  
141 1 Y 1 B ALA 75  ? B ALA 75  
142 1 Y 1 B CYS 76  ? B CYS 76  
143 1 Y 1 B GLY 77  ? B GLY 77  
144 1 Y 1 B TYR 78  ? B TYR 78  
145 1 Y 1 B SER 79  ? B SER 79  
146 1 Y 1 B ASP 80  ? B ASP 80  
147 1 Y 1 B ARG 81  ? B ARG 81  
148 1 Y 1 B VAL 82  ? B VAL 82  
149 1 Y 1 B LEU 83  ? B LEU 83  
150 1 Y 1 B GLN 84  ? B GLN 84  
151 1 Y 1 B LEU 85  ? B LEU 85  
152 1 Y 1 B THR 86  ? B THR 86  
153 1 Y 1 B LEU 87  ? B LEU 87  
154 1 Y 1 B GLY 88  ? B GLY 88  
155 1 Y 1 B ASN 89  ? B ASN 89  
156 1 Y 1 B SER 90  ? B SER 90  
157 1 Y 1 B SER 114 ? B SER 114 
158 1 Y 1 B GLU 115 ? B GLU 115 
159 1 Y 1 B ALA 116 ? B ALA 116 
160 1 Y 1 B ASN 117 ? B ASN 117 
161 1 Y 1 B PRO 118 ? B PRO 118 
162 1 Y 1 B VAL 119 ? B VAL 119 
163 1 Y 1 B ASP 120 ? B ASP 120 
164 1 Y 1 B GLN 121 ? B GLN 121 
165 1 Y 1 B PRO 122 ? B PRO 122 
166 1 Y 1 B THR 123 ? B THR 123 
167 1 Y 1 B GLU 124 ? B GLU 124 
168 1 Y 1 B ASN 206 ? B ASN 206 
169 1 Y 1 B THR 207 ? B THR 207 
170 1 Y 1 B THR 208 ? B THR 208 
171 1 Y 1 B THR 209 ? B THR 209 
172 1 Y 1 B MET 210 ? B MET 210 
173 1 Y 1 B HIS 211 ? B HIS 211 
174 1 Y 1 B PHE 230 ? B PHE 230 
175 1 Y 1 B THR 231 ? B THR 231 
176 1 Y 1 B PRO 232 ? B PRO 232 
177 1 Y 1 B ASP 233 ? B ASP 233 
178 1 Y 1 B ASN 234 ? B ASN 234 
179 1 Y 1 B ASN 235 ? B ASN 235 
180 1 Y 1 B GLN 236 ? B GLN 236 
181 1 Y 1 B THR 237 ? B THR 237 
182 1 Y 1 B SER 238 ? B SER 238 
183 1 Y 1 B PRO 239 ? B PRO 239 
184 1 Y 1 B ALA 240 ? B ALA 240 
185 1 Y 1 B ARG 241 ? B ARG 241 
186 1 Y 1 B THR 336 ? B THR 336 
187 1 Y 1 B LEU 337 ? B LEU 337 
188 1 Y 1 B PRO 338 ? B PRO 338 
189 1 Y 1 B ARG 339 ? B ARG 339 
190 1 Y 1 B LEU 340 ? B LEU 340 
191 1 Y 1 B GLN 341 ? B GLN 341 
192 1 Y 1 C LYS 234 ? C LYS 234 
193 1 Y 1 C ALA 235 ? C ALA 235 
194 1 Y 1 C LEU 236 ? C LEU 236 
195 1 Y 1 C ALA 237 ? C ALA 237 
196 1 Y 1 C GLN 238 ? C GLN 238 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-16 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           9F0K 
_em_admin.last_update        2025-01-29 
_em_admin.map_release_date   2025-01-29 
_em_admin.title              
;Poliovirus type 1 (strain Mahoney) expanded conformation stabilised virus-like particle (PV1 SC6b) from a mammalian expression system
;
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 1  x  ? 1 DPBS 
1 20 mM ? 2 EDTA 
# 
_em_ctf_correction.details                  'CTF correction performed in RELION v3.0.7 using CTFFIND4.' 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                5.84 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          12081 
_em_entity_assembly_naturalsource.organism             'Human poliovirus 1 Mahoney' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               Mahoney 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          10036 
_em_entity_assembly_recombinant.organism             'Mesocricetus auratus' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               1.27 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         33.78 
_em_image_recording.details                             'Pixel sampling was 1.08 A/pixel.' 
_em_image_recording.detector_mode                       INTEGRATING 
_em_image_recording.film_or_detector_model              'FEI FALCON III (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     5104 
# 
_em_particle_selection.details                  
'Particle picking was performed using crYOLO after training the neural network on approx. 100 manually picked particles.' 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   7185 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? crYOLO         ?            
'IMAGE ACQUISITION'        ? 2  1 ? 1 ?              ?            
MASKING                    ? 3  1 1 1 ?              ?            
'CTF CORRECTION'           ? 4  1 ? ? RELION         3.0.7        
'LAYERLINE INDEXING'       ? 5  1 1 1 ?              ?            
'DIFFRACTION INDEXING'     ? 6  1 1 1 ?              ?            
'MODEL FITTING'            ? 7  1 1 ? 'UCSF Chimera' 1.16         
'MODEL FITTING'            ? 8  ? 1 ? Coot           0.9.6        
OTHER                      ? 9  1 1 1 ?              ?            
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? RELION         3.0.7        
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? RELION         3.0.7        
CLASSIFICATION             ? 12 1 ? ? RELION         3.0.7        
RECONSTRUCTION             ? 13 1 ? ? RELION         3.0.7        
'MODEL REFINEMENT'         ? 14 ? 1 ? PHENIX         1.20.1_4487: 
# 
_em_specimen.concentration           0.38 
_em_specimen.details                 'Sample purified by sucrose density gradient ultracentrifugation.' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_em_virus_natural_host.entity_assembly_id   1 
_em_virus_natural_host.id                   1 
_em_virus_natural_host.ncbi_tax_id          9606 
_em_virus_natural_host.organism             'Homo sapiens' 
_em_virus_natural_host.strain               ? 
# 
_em_virus_shell.diameter             310 
_em_virus_shell.entity_assembly_id   1 
_em_virus_shell.id                   1 
_em_virus_shell.name                 'Virus shell 1' 
_em_virus_shell.triangulation        1 
# 
_pdbx_audit_support.funding_organization   'Bill & Melinda Gates Foundation' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           RG.IMCB.I8-TSA-083 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1HXS 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9F0K 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . GLN A 1 68  ? 182.308 259.006 321.356 1.00 72.15  ? 68  GLN A N   1 
ATOM 2    C CA  . GLN A 1 68  ? 182.470 259.300 322.774 1.00 74.83  ? 68  GLN A CA  1 
ATOM 3    C C   . GLN A 1 68  ? 183.211 260.617 322.960 1.00 73.14  ? 68  GLN A C   1 
ATOM 4    O O   . GLN A 1 68  ? 184.386 260.734 322.619 1.00 68.77  ? 68  GLN A O   1 
ATOM 5    C CB  . GLN A 1 68  ? 183.219 258.168 323.478 1.00 72.17  ? 68  GLN A CB  1 
ATOM 6    C CG  . GLN A 1 68  ? 183.334 258.343 324.984 1.00 73.14  ? 68  GLN A CG  1 
ATOM 7    C CD  . GLN A 1 68  ? 184.115 257.224 325.641 1.00 74.86  ? 68  GLN A CD  1 
ATOM 8    O OE1 . GLN A 1 68  ? 184.614 256.321 324.968 1.00 74.89  ? 68  GLN A OE1 1 
ATOM 9    N NE2 . GLN A 1 68  ? 184.228 257.278 326.965 1.00 72.73  ? 68  GLN A NE2 1 
ATOM 10   N N   . HIS A 1 69  ? 182.513 261.608 323.513 1.00 74.76  ? 69  HIS A N   1 
ATOM 11   C CA  . HIS A 1 69  ? 183.073 262.932 323.734 1.00 75.29  ? 69  HIS A CA  1 
ATOM 12   C C   . HIS A 1 69  ? 183.461 263.165 325.189 1.00 74.88  ? 69  HIS A C   1 
ATOM 13   O O   . HIS A 1 69  ? 183.600 264.319 325.610 1.00 72.13  ? 69  HIS A O   1 
ATOM 14   C CB  . HIS A 1 69  ? 182.083 264.000 323.268 1.00 75.72  ? 69  HIS A CB  1 
ATOM 15   C CG  . HIS A 1 69  ? 181.897 264.038 321.783 1.00 78.97  ? 69  HIS A CG  1 
ATOM 16   N ND1 . HIS A 1 69  ? 182.729 264.753 320.948 1.00 76.69  ? 69  HIS A ND1 1 
ATOM 17   C CD2 . HIS A 1 69  ? 180.982 263.444 320.982 1.00 76.70  ? 69  HIS A CD2 1 
ATOM 18   C CE1 . HIS A 1 69  ? 182.331 264.600 319.698 1.00 77.29  ? 69  HIS A CE1 1 
ATOM 19   N NE2 . HIS A 1 69  ? 181.273 263.810 319.691 1.00 78.72  ? 69  HIS A NE2 1 
ATOM 20   N N   . ARG A 1 70  ? 183.633 262.099 325.965 1.00 59.32  ? 70  ARG A N   1 
ATOM 21   C CA  . ARG A 1 70  ? 184.083 262.192 327.346 1.00 57.50  ? 70  ARG A CA  1 
ATOM 22   C C   . ARG A 1 70  ? 185.346 261.363 327.515 1.00 56.22  ? 70  ARG A C   1 
ATOM 23   O O   . ARG A 1 70  ? 185.400 260.211 327.073 1.00 57.26  ? 70  ARG A O   1 
ATOM 24   C CB  . ARG A 1 70  ? 183.006 261.710 328.310 1.00 52.57  ? 70  ARG A CB  1 
ATOM 25   C CG  . ARG A 1 70  ? 181.760 262.565 328.323 1.00 48.12  ? 70  ARG A CG  1 
ATOM 26   C CD  . ARG A 1 70  ? 180.763 262.017 329.314 1.00 53.02  ? 70  ARG A CD  1 
ATOM 27   N NE  . ARG A 1 70  ? 180.466 260.618 329.037 1.00 52.15  ? 70  ARG A NE  1 
ATOM 28   C CZ  . ARG A 1 70  ? 179.911 259.783 329.901 1.00 50.39  ? 70  ARG A CZ  1 
ATOM 29   N NH1 . ARG A 1 70  ? 179.574 260.172 331.118 1.00 45.99  ? 70  ARG A NH1 1 
ATOM 30   N NH2 . ARG A 1 70  ? 179.691 258.524 329.535 1.00 56.17  ? 70  ARG A NH2 1 
ATOM 31   N N   . SER A 1 71  ? 186.351 261.948 328.156 1.00 53.07  ? 71  SER A N   1 
ATOM 32   C CA  . SER A 1 71  ? 187.646 261.317 328.338 1.00 54.61  ? 71  SER A CA  1 
ATOM 33   C C   . SER A 1 71  ? 187.864 260.981 329.806 1.00 54.81  ? 71  SER A C   1 
ATOM 34   O O   . SER A 1 71  ? 187.329 261.641 330.700 1.00 51.13  ? 71  SER A O   1 
ATOM 35   C CB  . SER A 1 71  ? 188.779 262.225 327.846 1.00 53.66  ? 71  SER A CB  1 
ATOM 36   O OG  . SER A 1 71  ? 188.730 262.396 326.441 1.00 53.31  ? 71  SER A OG  1 
ATOM 37   N N   . ARG A 1 72  ? 188.656 259.938 330.040 1.00 46.64  ? 72  ARG A N   1 
ATOM 38   C CA  . ARG A 1 72  ? 189.034 259.509 331.379 1.00 41.04  ? 72  ARG A CA  1 
ATOM 39   C C   . ARG A 1 72  ? 190.413 260.019 331.774 1.00 44.91  ? 72  ARG A C   1 
ATOM 40   O O   . ARG A 1 72  ? 191.083 259.412 332.614 1.00 54.07  ? 72  ARG A O   1 
ATOM 41   C CB  . ARG A 1 72  ? 188.985 257.986 331.464 1.00 43.86  ? 72  ARG A CB  1 
ATOM 42   C CG  . ARG A 1 72  ? 187.745 257.443 332.119 1.00 41.29  ? 72  ARG A CG  1 
ATOM 43   C CD  . ARG A 1 72  ? 187.688 255.940 331.992 1.00 45.79  ? 72  ARG A CD  1 
ATOM 44   N NE  . ARG A 1 72  ? 186.610 255.367 332.785 1.00 48.71  ? 72  ARG A NE  1 
ATOM 45   C CZ  . ARG A 1 72  ? 186.214 254.105 332.703 1.00 50.99  ? 72  ARG A CZ  1 
ATOM 46   N NH1 . ARG A 1 72  ? 186.771 253.261 331.853 1.00 54.73  ? 72  ARG A NH1 1 
ATOM 47   N NH2 . ARG A 1 72  ? 185.231 253.682 333.492 1.00 49.20  ? 72  ARG A NH2 1 
ATOM 48   N N   . SER A 1 73  ? 190.846 261.134 331.194 1.00 36.45  ? 73  SER A N   1 
ATOM 49   C CA  . SER A 1 73  ? 192.208 261.613 331.375 1.00 39.36  ? 73  SER A CA  1 
ATOM 50   C C   . SER A 1 73  ? 192.398 262.439 332.636 1.00 33.99  ? 73  SER A C   1 
ATOM 51   O O   . SER A 1 73  ? 193.527 262.853 332.910 1.00 33.39  ? 73  SER A O   1 
ATOM 52   C CB  . SER A 1 73  ? 192.636 262.439 330.164 1.00 36.40  ? 73  SER A CB  1 
ATOM 53   O OG  . SER A 1 73  ? 191.929 263.663 330.113 1.00 36.00  ? 73  SER A OG  1 
ATOM 54   N N   . GLU A 1 74  ? 191.343 262.705 333.403 1.00 34.61  ? 74  GLU A N   1 
ATOM 55   C CA  . GLU A 1 74  ? 191.493 263.435 334.653 1.00 35.69  ? 74  GLU A CA  1 
ATOM 56   C C   . GLU A 1 74  ? 191.516 262.525 335.870 1.00 36.11  ? 74  GLU A C   1 
ATOM 57   O O   . GLU A 1 74  ? 191.860 262.988 336.961 1.00 42.59  ? 74  GLU A O   1 
ATOM 58   C CB  . GLU A 1 74  ? 190.374 264.466 334.816 1.00 34.81  ? 74  GLU A CB  1 
ATOM 59   C CG  . GLU A 1 74  ? 190.569 265.357 336.034 1.00 37.69  ? 74  GLU A CG  1 
ATOM 60   C CD  . GLU A 1 74  ? 189.780 266.645 335.965 1.00 46.83  ? 74  GLU A CD  1 
ATOM 61   O OE1 . GLU A 1 74  ? 188.982 266.802 335.020 1.00 54.99  ? 74  GLU A OE1 1 
ATOM 62   O OE2 . GLU A 1 74  ? 189.960 267.500 336.858 1.00 41.77  ? 74  GLU A OE2 1 
ATOM 63   N N   . SER A 1 75  ? 191.157 261.257 335.719 1.00 34.78  ? 75  SER A N   1 
ATOM 64   C CA  . SER A 1 75  ? 191.288 260.286 336.793 1.00 37.47  ? 75  SER A CA  1 
ATOM 65   C C   . SER A 1 75  ? 192.585 259.496 336.709 1.00 40.70  ? 75  SER A C   1 
ATOM 66   O O   . SER A 1 75  ? 192.838 258.656 337.576 1.00 43.75  ? 75  SER A O   1 
ATOM 67   C CB  . SER A 1 75  ? 190.100 259.324 336.780 1.00 32.60  ? 75  SER A CB  1 
ATOM 68   O OG  . SER A 1 75  ? 190.074 258.583 335.578 1.00 39.85  ? 75  SER A OG  1 
ATOM 69   N N   . SER A 1 76  ? 193.413 259.751 335.700 1.00 36.93  ? 76  SER A N   1 
ATOM 70   C CA  . SER A 1 76  ? 194.670 259.040 335.568 1.00 30.56  ? 76  SER A CA  1 
ATOM 71   C C   . SER A 1 76  ? 195.495 259.178 336.840 1.00 34.90  ? 76  SER A C   1 
ATOM 72   O O   . SER A 1 76  ? 195.241 260.033 337.691 1.00 35.58  ? 76  SER A O   1 
ATOM 73   C CB  . SER A 1 76  ? 195.461 259.567 334.377 1.00 34.68  ? 76  SER A CB  1 
ATOM 74   O OG  . SER A 1 76  ? 194.765 259.336 333.170 1.00 40.99  ? 76  SER A OG  1 
ATOM 75   N N   . ILE A 1 77  ? 196.489 258.301 336.972 1.00 37.73  ? 77  ILE A N   1 
ATOM 76   C CA  . ILE A 1 77  ? 197.324 258.305 338.168 1.00 32.05  ? 77  ILE A CA  1 
ATOM 77   C C   . ILE A 1 77  ? 198.107 259.605 338.262 1.00 38.89  ? 77  ILE A C   1 
ATOM 78   O O   . ILE A 1 77  ? 198.188 260.225 339.330 1.00 43.69  ? 77  ILE A O   1 
ATOM 79   C CB  . ILE A 1 77  ? 198.251 257.077 338.165 1.00 31.32  ? 77  ILE A CB  1 
ATOM 80   C CG1 . ILE A 1 77  ? 197.428 255.791 338.035 1.00 35.69  ? 77  ILE A CG1 1 
ATOM 81   C CG2 . ILE A 1 77  ? 199.092 257.040 339.422 1.00 36.16  ? 77  ILE A CG2 1 
ATOM 82   C CD1 . ILE A 1 77  ? 196.377 255.612 339.106 1.00 35.89  ? 77  ILE A CD1 1 
ATOM 83   N N   . GLU A 1 78  ? 198.686 260.046 337.146 1.00 39.13  ? 78  GLU A N   1 
ATOM 84   C CA  . GLU A 1 78  ? 199.439 261.293 337.149 1.00 36.36  ? 78  GLU A CA  1 
ATOM 85   C C   . GLU A 1 78  ? 198.548 262.462 337.546 1.00 40.55  ? 78  GLU A C   1 
ATOM 86   O O   . GLU A 1 78  ? 198.926 263.295 338.375 1.00 42.17  ? 78  GLU A O   1 
ATOM 87   C CB  . GLU A 1 78  ? 200.052 261.526 335.770 1.00 36.19  ? 78  GLU A CB  1 
ATOM 88   C CG  . GLU A 1 78  ? 201.197 262.523 335.756 1.00 45.15  ? 78  GLU A CG  1 
ATOM 89   C CD  . GLU A 1 78  ? 202.433 262.011 336.476 1.00 50.03  ? 78  GLU A CD  1 
ATOM 90   O OE1 . GLU A 1 78  ? 202.371 260.902 337.046 1.00 43.42  ? 78  GLU A OE1 1 
ATOM 91   O OE2 . GLU A 1 78  ? 203.467 262.712 336.467 1.00 44.13  ? 78  GLU A OE2 1 
ATOM 92   N N   . SER A 1 79  ? 197.351 262.532 336.970 1.00 32.07  ? 79  SER A N   1 
ATOM 93   C CA  . SER A 1 79  ? 196.433 263.612 337.306 1.00 32.06  ? 79  SER A CA  1 
ATOM 94   C C   . SER A 1 79  ? 195.966 263.510 338.751 1.00 39.11  ? 79  SER A C   1 
ATOM 95   O O   . SER A 1 79  ? 195.786 264.528 339.427 1.00 41.72  ? 79  SER A O   1 
ATOM 96   C CB  . SER A 1 79  ? 195.244 263.581 336.358 1.00 33.80  ? 79  SER A CB  1 
ATOM 97   O OG  . SER A 1 79  ? 195.683 263.589 335.015 1.00 40.95  ? 79  SER A OG  1 
ATOM 98   N N   . PHE A 1 80  ? 195.760 262.289 339.237 1.00 37.43  ? 80  PHE A N   1 
ATOM 99   C CA  . PHE A 1 80  ? 195.238 262.098 340.583 1.00 29.37  ? 80  PHE A CA  1 
ATOM 100  C C   . PHE A 1 80  ? 196.276 262.439 341.645 1.00 29.39  ? 80  PHE A C   1 
ATOM 101  O O   . PHE A 1 80  ? 195.914 262.873 342.744 1.00 26.84  ? 80  PHE A O   1 
ATOM 102  C CB  . PHE A 1 80  ? 194.753 260.655 340.732 1.00 30.61  ? 80  PHE A CB  1 
ATOM 103  C CG  . PHE A 1 80  ? 194.092 260.362 342.043 1.00 26.55  ? 80  PHE A CG  1 
ATOM 104  C CD1 . PHE A 1 80  ? 192.828 260.835 342.315 1.00 30.50  ? 80  PHE A CD1 1 
ATOM 105  C CD2 . PHE A 1 80  ? 194.727 259.591 342.993 1.00 35.99  ? 80  PHE A CD2 1 
ATOM 106  C CE1 . PHE A 1 80  ? 192.218 260.562 343.516 1.00 34.98  ? 80  PHE A CE1 1 
ATOM 107  C CE2 . PHE A 1 80  ? 194.124 259.316 344.198 1.00 31.77  ? 80  PHE A CE2 1 
ATOM 108  C CZ  . PHE A 1 80  ? 192.868 259.800 344.459 1.00 38.91  ? 80  PHE A CZ  1 
ATOM 109  N N   . PHE A 1 81  ? 197.561 262.264 341.341 1.00 32.99  ? 81  PHE A N   1 
ATOM 110  C CA  . PHE A 1 81  ? 198.626 262.444 342.324 1.00 33.40  ? 81  PHE A CA  1 
ATOM 111  C C   . PHE A 1 81  ? 199.492 263.668 342.087 1.00 36.33  ? 81  PHE A C   1 
ATOM 112  O O   . PHE A 1 81  ? 199.795 264.391 343.037 1.00 31.22  ? 81  PHE A O   1 
ATOM 113  C CB  . PHE A 1 81  ? 199.539 261.214 342.351 1.00 31.40  ? 81  PHE A CB  1 
ATOM 114  C CG  . PHE A 1 81  ? 198.956 260.049 343.071 1.00 33.32  ? 81  PHE A CG  1 
ATOM 115  C CD1 . PHE A 1 81  ? 198.815 260.071 344.442 1.00 35.38  ? 81  PHE A CD1 1 
ATOM 116  C CD2 . PHE A 1 81  ? 198.561 258.927 342.380 1.00 28.64  ? 81  PHE A CD2 1 
ATOM 117  C CE1 . PHE A 1 81  ? 198.281 258.999 345.105 1.00 36.02  ? 81  PHE A CE1 1 
ATOM 118  C CE2 . PHE A 1 81  ? 198.025 257.856 343.036 1.00 33.67  ? 81  PHE A CE2 1 
ATOM 119  C CZ  . PHE A 1 81  ? 197.885 257.888 344.401 1.00 37.37  ? 81  PHE A CZ  1 
ATOM 120  N N   . ALA A 1 82  ? 199.900 263.925 340.847 1.00 36.27  ? 82  ALA A N   1 
ATOM 121  C CA  . ALA A 1 82  ? 200.935 264.919 340.573 1.00 29.66  ? 82  ALA A CA  1 
ATOM 122  C C   . ALA A 1 82  ? 200.350 266.312 340.775 1.00 34.85  ? 82  ALA A C   1 
ATOM 123  O O   . ALA A 1 82  ? 199.948 267.004 339.837 1.00 34.62  ? 82  ALA A O   1 
ATOM 124  C CB  . ALA A 1 82  ? 201.495 264.739 339.168 1.00 26.84  ? 82  ALA A CB  1 
ATOM 125  N N   . ARG A 1 83  ? 200.302 266.724 342.040 1.00 40.08  ? 83  ARG A N   1 
ATOM 126  C CA  . ARG A 1 83  ? 199.847 268.053 342.421 1.00 38.20  ? 83  ARG A CA  1 
ATOM 127  C C   . ARG A 1 83  ? 200.674 268.516 343.608 1.00 36.30  ? 83  ARG A C   1 
ATOM 128  O O   . ARG A 1 83  ? 200.874 267.753 344.556 1.00 39.73  ? 83  ARG A O   1 
ATOM 129  C CB  . ARG A 1 83  ? 198.359 268.050 342.773 1.00 34.78  ? 83  ARG A CB  1 
ATOM 130  C CG  . ARG A 1 83  ? 197.478 267.512 341.672 1.00 41.88  ? 83  ARG A CG  1 
ATOM 131  C CD  . ARG A 1 83  ? 196.122 268.176 341.657 1.00 44.19  ? 83  ARG A CD  1 
ATOM 132  N NE  . ARG A 1 83  ? 195.354 267.766 340.490 1.00 39.63  ? 83  ARG A NE  1 
ATOM 133  C CZ  . ARG A 1 83  ? 194.327 268.440 339.993 1.00 45.33  ? 83  ARG A CZ  1 
ATOM 134  N NH1 . ARG A 1 83  ? 193.922 269.578 340.530 1.00 44.34  ? 83  ARG A NH1 1 
ATOM 135  N NH2 . ARG A 1 83  ? 193.693 267.962 338.927 1.00 46.58  ? 83  ARG A NH2 1 
ATOM 136  N N   . GLY A 1 84  ? 201.148 269.759 343.557 1.00 36.67  ? 84  GLY A N   1 
ATOM 137  C CA  . GLY A 1 84  ? 202.062 270.249 344.576 1.00 30.37  ? 84  GLY A CA  1 
ATOM 138  C C   . GLY A 1 84  ? 201.324 270.718 345.812 1.00 31.44  ? 84  GLY A C   1 
ATOM 139  O O   . GLY A 1 84  ? 200.371 271.497 345.721 1.00 39.71  ? 84  GLY A O   1 
ATOM 140  N N   . ALA A 1 85  ? 201.765 270.245 346.976 1.00 24.89  ? 85  ALA A N   1 
ATOM 141  C CA  . ALA A 1 85  ? 201.180 270.650 348.243 1.00 23.10  ? 85  ALA A CA  1 
ATOM 142  C C   . ALA A 1 85  ? 202.278 270.853 349.273 1.00 24.59  ? 85  ALA A C   1 
ATOM 143  O O   . ALA A 1 85  ? 203.322 270.202 349.225 1.00 27.45  ? 85  ALA A O   1 
ATOM 144  C CB  . ALA A 1 85  ? 200.180 269.620 348.758 1.00 31.77  ? 85  ALA A CB  1 
ATOM 145  N N   . CYS A 1 86  ? 202.023 271.757 350.212 1.00 31.52  ? 86  CYS A N   1 
ATOM 146  C CA  . CYS A 1 86  ? 202.996 272.053 351.251 1.00 24.12  ? 86  CYS A CA  1 
ATOM 147  C C   . CYS A 1 86  ? 203.111 270.877 352.207 1.00 25.08  ? 86  CYS A C   1 
ATOM 148  O O   . CYS A 1 86  ? 202.103 270.345 352.678 1.00 43.05  ? 86  CYS A O   1 
ATOM 149  C CB  . CYS A 1 86  ? 202.587 273.312 352.010 1.00 27.85  ? 86  CYS A CB  1 
ATOM 150  S SG  . CYS A 1 86  ? 203.767 273.865 353.250 1.00 59.62  ? 86  CYS A SG  1 
ATOM 151  N N   . VAL A 1 87  ? 204.346 270.477 352.503 1.00 32.35  ? 87  VAL A N   1 
ATOM 152  C CA  . VAL A 1 87  ? 204.595 269.354 353.388 1.00 30.32  ? 87  VAL A CA  1 
ATOM 153  C C   . VAL A 1 87  ? 205.205 269.783 354.718 1.00 33.63  ? 87  VAL A C   1 
ATOM 154  O O   . VAL A 1 87  ? 205.010 269.088 355.721 1.00 37.09  ? 87  VAL A O   1 
ATOM 155  C CB  . VAL A 1 87  ? 205.485 268.299 352.699 1.00 27.31  ? 87  VAL A CB  1 
ATOM 156  C CG1 . VAL A 1 87  ? 204.743 267.662 351.552 1.00 31.07  ? 87  VAL A CG1 1 
ATOM 157  C CG2 . VAL A 1 87  ? 206.768 268.921 352.211 1.00 25.80  ? 87  VAL A CG2 1 
ATOM 158  N N   . THR A 1 88  ? 205.932 270.896 354.767 1.00 37.58  ? 88  THR A N   1 
ATOM 159  C CA  . THR A 1 88  ? 206.551 271.304 356.018 1.00 33.55  ? 88  THR A CA  1 
ATOM 160  C C   . THR A 1 88  ? 206.903 272.783 355.981 1.00 33.69  ? 88  THR A C   1 
ATOM 161  O O   . THR A 1 88  ? 207.052 273.389 354.914 1.00 40.60  ? 88  THR A O   1 
ATOM 162  C CB  . THR A 1 88  ? 207.806 270.481 356.315 1.00 42.86  ? 88  THR A CB  1 
ATOM 163  O OG1 . THR A 1 88  ? 208.328 270.847 357.597 1.00 48.60  ? 88  THR A OG1 1 
ATOM 164  C CG2 . THR A 1 88  ? 208.866 270.726 355.259 1.00 44.11  ? 88  THR A CG2 1 
ATOM 165  N N   . ILE A 1 89  ? 207.049 273.340 357.181 1.00 31.05  ? 89  ILE A N   1 
ATOM 166  C CA  . ILE A 1 89  ? 207.479 274.714 357.404 1.00 29.65  ? 89  ILE A CA  1 
ATOM 167  C C   . ILE A 1 89  ? 208.678 274.664 358.340 1.00 36.81  ? 89  ILE A C   1 
ATOM 168  O O   . ILE A 1 89  ? 208.566 274.178 359.472 1.00 43.05  ? 89  ILE A O   1 
ATOM 169  C CB  . ILE A 1 89  ? 206.353 275.571 358.001 1.00 29.54  ? 89  ILE A CB  1 
ATOM 170  C CG1 . ILE A 1 89  ? 205.135 275.547 357.078 1.00 29.73  ? 89  ILE A CG1 1 
ATOM 171  C CG2 . ILE A 1 89  ? 206.832 276.994 358.238 1.00 33.39  ? 89  ILE A CG2 1 
ATOM 172  C CD1 . ILE A 1 89  ? 203.958 276.337 357.585 1.00 33.07  ? 89  ILE A CD1 1 
ATOM 173  N N   . MET A 1 90  ? 209.813 275.174 357.876 1.00 39.78  ? 90  MET A N   1 
ATOM 174  C CA  . MET A 1 90  ? 211.073 275.118 358.605 1.00 34.98  ? 90  MET A CA  1 
ATOM 175  C C   . MET A 1 90  ? 211.488 276.526 359.004 1.00 35.29  ? 90  MET A C   1 
ATOM 176  O O   . MET A 1 90  ? 211.569 277.416 358.154 1.00 40.89  ? 90  MET A O   1 
ATOM 177  C CB  . MET A 1 90  ? 212.154 274.461 357.747 1.00 38.29  ? 90  MET A CB  1 
ATOM 178  C CG  . MET A 1 90  ? 211.837 273.026 357.371 1.00 43.39  ? 90  MET A CG  1 
ATOM 179  S SD  . MET A 1 90  ? 212.939 272.347 356.120 1.00 49.16  ? 90  MET A SD  1 
ATOM 180  C CE  . MET A 1 90  ? 214.514 272.568 356.924 1.00 39.49  ? 90  MET A CE  1 
ATOM 181  N N   . THR A 1 91  ? 211.755 276.722 360.289 1.00 36.47  ? 91  THR A N   1 
ATOM 182  C CA  . THR A 1 91  ? 212.043 278.037 360.844 1.00 41.08  ? 91  THR A CA  1 
ATOM 183  C C   . THR A 1 91  ? 213.531 278.172 361.130 1.00 44.18  ? 91  THR A C   1 
ATOM 184  O O   . THR A 1 91  ? 214.131 277.291 361.753 1.00 41.14  ? 91  THR A O   1 
ATOM 185  C CB  . THR A 1 91  ? 211.245 278.272 362.127 1.00 44.00  ? 91  THR A CB  1 
ATOM 186  O OG1 . THR A 1 91  ? 209.850 278.347 361.816 1.00 47.98  ? 91  THR A OG1 1 
ATOM 187  C CG2 . THR A 1 91  ? 211.681 279.559 362.805 1.00 41.26  ? 91  THR A CG2 1 
ATOM 188  N N   . VAL A 1 92  ? 214.119 279.278 360.674 1.00 47.57  ? 92  VAL A N   1 
ATOM 189  C CA  . VAL A 1 92  ? 215.503 279.624 360.959 1.00 42.74  ? 92  VAL A CA  1 
ATOM 190  C C   . VAL A 1 92  ? 215.533 281.090 361.366 1.00 45.03  ? 92  VAL A C   1 
ATOM 191  O O   . VAL A 1 92  ? 214.528 281.796 361.289 1.00 55.33  ? 92  VAL A O   1 
ATOM 192  C CB  . VAL A 1 92  ? 216.432 279.373 359.757 1.00 40.72  ? 92  VAL A CB  1 
ATOM 193  C CG1 . VAL A 1 92  ? 216.355 277.927 359.326 1.00 42.71  ? 92  VAL A CG1 1 
ATOM 194  C CG2 . VAL A 1 92  ? 216.067 280.285 358.611 1.00 44.66  ? 92  VAL A CG2 1 
ATOM 195  N N   . ASP A 1 93  ? 216.697 281.553 361.805 1.00 47.87  ? 93  ASP A N   1 
ATOM 196  C CA  . ASP A 1 93  ? 216.807 282.960 362.158 1.00 51.73  ? 93  ASP A CA  1 
ATOM 197  C C   . ASP A 1 93  ? 218.266 283.380 362.196 1.00 58.08  ? 93  ASP A C   1 
ATOM 198  O O   . ASP A 1 93  ? 219.169 282.559 362.368 1.00 58.99  ? 93  ASP A O   1 
ATOM 199  C CB  . ASP A 1 93  ? 216.127 283.250 363.499 1.00 55.63  ? 93  ASP A CB  1 
ATOM 200  C CG  . ASP A 1 93  ? 216.762 282.509 364.651 1.00 61.14  ? 93  ASP A CG  1 
ATOM 201  O OD1 . ASP A 1 93  ? 217.833 281.900 364.461 1.00 63.26  ? 93  ASP A OD1 1 
ATOM 202  O OD2 . ASP A 1 93  ? 216.184 282.533 365.757 1.00 63.48  ? 93  ASP A OD2 1 
ATOM 203  N N   . ASN A 1 94  ? 218.476 284.680 362.022 1.00 60.25  ? 94  ASN A N   1 
ATOM 204  C CA  . ASN A 1 94  ? 219.780 285.306 362.180 1.00 61.70  ? 94  ASN A CA  1 
ATOM 205  C C   . ASN A 1 94  ? 219.718 286.189 363.419 1.00 67.56  ? 94  ASN A C   1 
ATOM 206  O O   . ASN A 1 94  ? 218.975 287.187 363.420 1.00 72.24  ? 94  ASN A O   1 
ATOM 207  C CB  . ASN A 1 94  ? 220.133 286.128 360.941 1.00 63.09  ? 94  ASN A CB  1 
ATOM 208  C CG  . ASN A 1 94  ? 221.608 286.447 360.850 1.00 65.56  ? 94  ASN A CG  1 
ATOM 209  O OD1 . ASN A 1 94  ? 222.010 287.603 360.965 1.00 68.90  ? 94  ASN A OD1 1 
ATOM 210  N ND2 . ASN A 1 94  ? 222.424 285.423 360.639 1.00 61.69  ? 94  ASN A ND2 1 
ATOM 211  N N   . PRO A 1 95  ? 220.433 285.867 364.491 1.00 71.52  ? 95  PRO A N   1 
ATOM 212  C CA  . PRO A 1 95  ? 220.250 286.576 365.759 1.00 73.34  ? 95  PRO A CA  1 
ATOM 213  C C   . PRO A 1 95  ? 221.044 287.876 365.795 1.00 74.85  ? 95  PRO A C   1 
ATOM 214  O O   . PRO A 1 95  ? 221.817 288.192 364.895 1.00 73.25  ? 95  PRO A O   1 
ATOM 215  C CB  . PRO A 1 95  ? 220.772 285.572 366.786 1.00 71.41  ? 95  PRO A CB  1 
ATOM 216  C CG  . PRO A 1 95  ? 221.849 284.859 366.065 1.00 70.23  ? 95  PRO A CG  1 
ATOM 217  C CD  . PRO A 1 95  ? 221.419 284.780 364.620 1.00 67.82  ? 95  PRO A CD  1 
ATOM 218  N N   . ALA A 1 96  ? 220.833 288.633 366.868 1.00 82.33  ? 96  ALA A N   1 
ATOM 219  C CA  . ALA A 1 96  ? 221.539 289.890 367.053 1.00 82.53  ? 96  ALA A CA  1 
ATOM 220  C C   . ALA A 1 96  ? 223.014 289.642 367.340 1.00 82.85  ? 96  ALA A C   1 
ATOM 221  O O   . ALA A 1 96  ? 223.392 288.659 367.982 1.00 81.01  ? 96  ALA A O   1 
ATOM 222  C CB  . ALA A 1 96  ? 220.914 290.688 368.196 1.00 81.56  ? 96  ALA A CB  1 
ATOM 223  N N   . SER A 1 97  ? 223.854 290.555 366.856 1.00 85.78  ? 97  SER A N   1 
ATOM 224  C CA  . SER A 1 97  ? 225.292 290.445 367.049 1.00 85.14  ? 97  SER A CA  1 
ATOM 225  C C   . SER A 1 97  ? 225.729 290.781 368.468 1.00 86.91  ? 97  SER A C   1 
ATOM 226  O O   . SER A 1 97  ? 226.889 290.532 368.813 1.00 86.94  ? 97  SER A O   1 
ATOM 227  C CB  . SER A 1 97  ? 226.022 291.355 366.059 1.00 84.08  ? 97  SER A CB  1 
ATOM 228  O OG  . SER A 1 97  ? 225.825 290.910 364.728 1.00 80.51  ? 97  SER A OG  1 
ATOM 229  N N   . THR A 1 98  ? 224.843 291.337 369.295 1.00 96.44  ? 98  THR A N   1 
ATOM 230  C CA  . THR A 1 98  ? 225.187 291.594 370.689 1.00 96.30  ? 98  THR A CA  1 
ATOM 231  C C   . THR A 1 98  ? 225.078 290.318 371.518 1.00 96.38  ? 98  THR A C   1 
ATOM 232  O O   . THR A 1 98  ? 226.069 289.846 372.085 1.00 96.78  ? 98  THR A O   1 
ATOM 233  C CB  . THR A 1 98  ? 224.281 292.685 371.267 1.00 96.47  ? 98  THR A CB  1 
ATOM 234  O OG1 . THR A 1 98  ? 222.920 292.239 371.249 1.00 99.29  ? 98  THR A OG1 1 
ATOM 235  C CG2 . THR A 1 98  ? 224.404 293.968 370.458 1.00 94.51  ? 98  THR A CG2 1 
ATOM 236  N N   . THR A 1 99  ? 223.879 289.746 371.597 1.00 95.53  ? 99  THR A N   1 
ATOM 237  C CA  . THR A 1 99  ? 223.692 288.470 372.272 1.00 95.94  ? 99  THR A CA  1 
ATOM 238  C C   . THR A 1 99  ? 224.266 287.357 371.407 1.00 96.57  ? 99  THR A C   1 
ATOM 239  O O   . THR A 1 99  ? 223.985 287.285 370.207 1.00 97.45  ? 99  THR A O   1 
ATOM 240  C CB  . THR A 1 99  ? 222.211 288.217 372.550 1.00 94.98  ? 99  THR A CB  1 
ATOM 241  O OG1 . THR A 1 99  ? 221.496 288.123 371.312 1.00 95.03  ? 99  THR A OG1 1 
ATOM 242  C CG2 . THR A 1 99  ? 221.624 289.343 373.386 1.00 93.28  ? 99  THR A CG2 1 
ATOM 243  N N   . ASN A 1 100 ? 225.069 286.486 372.019 1.00 95.20  ? 100 ASN A N   1 
ATOM 244  C CA  . ASN A 1 100 ? 225.844 285.491 371.291 1.00 94.80  ? 100 ASN A CA  1 
ATOM 245  C C   . ASN A 1 100 ? 225.228 284.098 371.363 1.00 95.51  ? 100 ASN A C   1 
ATOM 246  O O   . ASN A 1 100 ? 225.957 283.100 371.375 1.00 97.33  ? 100 ASN A O   1 
ATOM 247  C CB  . ASN A 1 100 ? 227.278 285.462 371.819 1.00 95.46  ? 100 ASN A CB  1 
ATOM 248  C CG  . ASN A 1 100 ? 227.945 286.821 371.765 1.00 96.80  ? 100 ASN A CG  1 
ATOM 249  O OD1 . ASN A 1 100 ? 228.434 287.327 372.775 1.00 96.03  ? 100 ASN A OD1 1 
ATOM 250  N ND2 . ASN A 1 100 ? 227.965 287.424 370.582 1.00 95.57  ? 100 ASN A ND2 1 
ATOM 251  N N   . LYS A 1 101 ? 223.903 284.003 371.404 1.00 87.23  ? 101 LYS A N   1 
ATOM 252  C CA  . LYS A 1 101 ? 223.271 282.694 371.411 1.00 88.49  ? 101 LYS A CA  1 
ATOM 253  C C   . LYS A 1 101 ? 223.442 282.022 370.051 1.00 88.06  ? 101 LYS A C   1 
ATOM 254  O O   . LYS A 1 101 ? 223.660 282.674 369.026 1.00 86.59  ? 101 LYS A O   1 
ATOM 255  C CB  . LYS A 1 101 ? 221.790 282.807 371.773 1.00 86.63  ? 101 LYS A CB  1 
ATOM 256  C CG  . LYS A 1 101 ? 220.958 283.611 370.794 1.00 87.49  ? 101 LYS A CG  1 
ATOM 257  C CD  . LYS A 1 101 ? 219.501 283.655 371.226 1.00 86.91  ? 101 LYS A CD  1 
ATOM 258  C CE  . LYS A 1 101 ? 218.639 284.385 370.214 1.00 85.67  ? 101 LYS A CE  1 
ATOM 259  N NZ  . LYS A 1 101 ? 219.056 285.804 370.052 1.00 86.09  ? 101 LYS A NZ  1 
ATOM 260  N N   . ASP A 1 102 ? 223.346 280.694 370.055 1.00 83.05  ? 102 ASP A N   1 
ATOM 261  C CA  . ASP A 1 102 ? 223.608 279.923 368.847 1.00 81.71  ? 102 ASP A CA  1 
ATOM 262  C C   . ASP A 1 102 ? 222.626 280.285 367.740 1.00 82.74  ? 102 ASP A C   1 
ATOM 263  O O   . ASP A 1 102 ? 221.445 280.538 367.986 1.00 82.48  ? 102 ASP A O   1 
ATOM 264  C CB  . ASP A 1 102 ? 223.523 278.426 369.147 1.00 82.13  ? 102 ASP A CB  1 
ATOM 265  C CG  . ASP A 1 102 ? 224.707 277.923 369.947 1.00 82.11  ? 102 ASP A CG  1 
ATOM 266  O OD1 . ASP A 1 102 ? 225.778 278.559 369.890 1.00 82.56  ? 102 ASP A OD1 1 
ATOM 267  O OD2 . ASP A 1 102 ? 224.569 276.885 370.627 1.00 81.72  ? 102 ASP A OD2 1 
ATOM 268  N N   . LYS A 1 103 ? 223.130 280.307 366.510 1.00 66.84  ? 103 LYS A N   1 
ATOM 269  C CA  . LYS A 1 103 ? 222.283 280.531 365.348 1.00 63.15  ? 103 LYS A CA  1 
ATOM 270  C C   . LYS A 1 103 ? 221.471 279.277 365.048 1.00 61.05  ? 103 LYS A C   1 
ATOM 271  O O   . LYS A 1 103 ? 222.022 278.178 364.952 1.00 61.95  ? 103 LYS A O   1 
ATOM 272  C CB  . LYS A 1 103 ? 223.145 280.908 364.147 1.00 61.57  ? 103 LYS A CB  1 
ATOM 273  C CG  . LYS A 1 103 ? 222.382 281.088 362.852 1.00 63.39  ? 103 LYS A CG  1 
ATOM 274  C CD  . LYS A 1 103 ? 223.289 281.595 361.741 1.00 63.15  ? 103 LYS A CD  1 
ATOM 275  C CE  . LYS A 1 103 ? 224.345 280.571 361.366 1.00 67.05  ? 103 LYS A CE  1 
ATOM 276  N NZ  . LYS A 1 103 ? 225.122 280.984 360.169 1.00 64.22  ? 103 LYS A NZ  1 
ATOM 277  N N   . LEU A 1 104 ? 220.160 279.438 364.902 1.00 53.65  ? 104 LEU A N   1 
ATOM 278  C CA  . LEU A 1 104 ? 219.301 278.292 364.647 1.00 53.18  ? 104 LEU A CA  1 
ATOM 279  C C   . LEU A 1 104 ? 219.461 277.788 363.219 1.00 52.38  ? 104 LEU A C   1 
ATOM 280  O O   . LEU A 1 104 ? 219.708 278.553 362.285 1.00 56.69  ? 104 LEU A O   1 
ATOM 281  C CB  . LEU A 1 104 ? 217.837 278.641 364.902 1.00 53.86  ? 104 LEU A CB  1 
ATOM 282  C CG  . LEU A 1 104 ? 217.413 278.663 366.369 1.00 56.65  ? 104 LEU A CG  1 
ATOM 283  C CD1 . LEU A 1 104 ? 218.008 279.864 367.081 1.00 57.06  ? 104 LEU A CD1 1 
ATOM 284  C CD2 . LEU A 1 104 ? 215.899 278.656 366.487 1.00 55.37  ? 104 LEU A CD2 1 
ATOM 285  N N   . PHE A 1 105 ? 219.316 276.477 363.063 1.00 42.52  ? 105 PHE A N   1 
ATOM 286  C CA  . PHE A 1 105 ? 219.285 275.830 361.763 1.00 41.84  ? 105 PHE A CA  1 
ATOM 287  C C   . PHE A 1 105 ? 218.179 274.787 361.799 1.00 46.09  ? 105 PHE A C   1 
ATOM 288  O O   . PHE A 1 105 ? 217.780 274.320 362.867 1.00 47.21  ? 105 PHE A O   1 
ATOM 289  C CB  . PHE A 1 105 ? 220.636 275.192 361.413 1.00 44.67  ? 105 PHE A CB  1 
ATOM 290  C CG  . PHE A 1 105 ? 220.974 274.000 362.254 1.00 48.95  ? 105 PHE A CG  1 
ATOM 291  C CD1 . PHE A 1 105 ? 221.179 274.133 363.612 1.00 47.75  ? 105 PHE A CD1 1 
ATOM 292  C CD2 . PHE A 1 105 ? 221.083 272.746 361.687 1.00 47.15  ? 105 PHE A CD2 1 
ATOM 293  C CE1 . PHE A 1 105 ? 221.478 273.044 364.386 1.00 46.70  ? 105 PHE A CE1 1 
ATOM 294  C CE2 . PHE A 1 105 ? 221.383 271.652 362.461 1.00 46.12  ? 105 PHE A CE2 1 
ATOM 295  C CZ  . PHE A 1 105 ? 221.580 271.803 363.812 1.00 47.04  ? 105 PHE A CZ  1 
ATOM 296  N N   . ALA A 1 106 ? 217.669 274.436 360.626 1.00 42.60  ? 106 ALA A N   1 
ATOM 297  C CA  . ALA A 1 106 ? 216.512 273.561 360.516 1.00 36.64  ? 106 ALA A CA  1 
ATOM 298  C C   . ALA A 1 106 ? 216.906 272.237 359.882 1.00 42.44  ? 106 ALA A C   1 
ATOM 299  O O   . ALA A 1 106 ? 217.711 272.205 358.950 1.00 46.78  ? 106 ALA A O   1 
ATOM 300  C CB  . ALA A 1 106 ? 215.412 274.220 359.688 1.00 40.02  ? 106 ALA A CB  1 
ATOM 301  N N   . VAL A 1 107 ? 216.337 271.149 360.393 1.00 36.94  ? 107 VAL A N   1 
ATOM 302  C CA  . VAL A 1 107 ? 216.546 269.812 359.846 1.00 33.25  ? 107 VAL A CA  1 
ATOM 303  C C   . VAL A 1 107 ? 215.200 269.108 359.792 1.00 33.28  ? 107 VAL A C   1 
ATOM 304  O O   . VAL A 1 107 ? 214.429 269.159 360.755 1.00 38.86  ? 107 VAL A O   1 
ATOM 305  C CB  . VAL A 1 107 ? 217.548 268.996 360.684 1.00 38.97  ? 107 VAL A CB  1 
ATOM 306  C CG1 . VAL A 1 107 ? 217.826 267.664 360.023 1.00 39.16  ? 107 VAL A CG1 1 
ATOM 307  C CG2 . VAL A 1 107 ? 218.833 269.772 360.873 1.00 41.87  ? 107 VAL A CG2 1 
ATOM 308  N N   . TRP A 1 108 ? 214.913 268.453 358.670 1.00 34.61  ? 108 TRP A N   1 
ATOM 309  C CA  . TRP A 1 108 ? 213.647 267.751 358.515 1.00 27.94  ? 108 TRP A CA  1 
ATOM 310  C C   . TRP A 1 108 ? 213.839 266.556 357.598 1.00 32.24  ? 108 TRP A C   1 
ATOM 311  O O   . TRP A 1 108 ? 214.350 266.699 356.485 1.00 37.59  ? 108 TRP A O   1 
ATOM 312  C CB  . TRP A 1 108 ? 212.568 268.683 357.956 1.00 33.73  ? 108 TRP A CB  1 
ATOM 313  C CG  . TRP A 1 108 ? 211.275 267.997 357.659 1.00 39.82  ? 108 TRP A CG  1 
ATOM 314  C CD1 . TRP A 1 108 ? 210.351 267.570 358.562 1.00 34.85  ? 108 TRP A CD1 1 
ATOM 315  C CD2 . TRP A 1 108 ? 210.757 267.664 356.369 1.00 36.61  ? 108 TRP A CD2 1 
ATOM 316  N NE1 . TRP A 1 108 ? 209.294 266.984 357.916 1.00 32.44  ? 108 TRP A NE1 1 
ATOM 317  C CE2 . TRP A 1 108 ? 209.519 267.030 356.567 1.00 26.87  ? 108 TRP A CE2 1 
ATOM 318  C CE3 . TRP A 1 108 ? 211.222 267.839 355.064 1.00 36.37  ? 108 TRP A CE3 1 
ATOM 319  C CZ2 . TRP A 1 108 ? 208.741 266.574 355.514 1.00 27.12  ? 108 TRP A CZ2 1 
ATOM 320  C CZ3 . TRP A 1 108 ? 210.449 267.383 354.023 1.00 34.53  ? 108 TRP A CZ3 1 
ATOM 321  C CH2 . TRP A 1 108 ? 209.222 266.758 354.252 1.00 32.04  ? 108 TRP A CH2 1 
ATOM 322  N N   . LYS A 1 109 ? 213.433 265.383 358.068 1.00 32.66  ? 109 LYS A N   1 
ATOM 323  C CA  . LYS A 1 109 ? 213.534 264.160 357.289 1.00 20.52  ? 109 LYS A CA  1 
ATOM 324  C C   . LYS A 1 109 ? 212.322 264.029 356.375 1.00 36.45  ? 109 LYS A C   1 
ATOM 325  O O   . LYS A 1 109 ? 211.184 264.220 356.810 1.00 38.75  ? 109 LYS A O   1 
ATOM 326  C CB  . LYS A 1 109 ? 213.638 262.949 358.213 1.00 28.40  ? 109 LYS A CB  1 
ATOM 327  C CG  . LYS A 1 109 ? 213.854 261.651 357.477 1.00 35.36  ? 109 LYS A CG  1 
ATOM 328  C CD  . LYS A 1 109 ? 213.463 260.457 358.314 1.00 32.64  ? 109 LYS A CD  1 
ATOM 329  C CE  . LYS A 1 109 ? 213.587 259.183 357.509 1.00 40.06  ? 109 LYS A CE  1 
ATOM 330  N NZ  . LYS A 1 109 ? 212.758 259.235 356.275 1.00 40.56  ? 109 LYS A NZ  1 
ATOM 331  N N   . ILE A 1 110 ? 212.570 263.680 355.115 1.00 36.31  ? 110 ILE A N   1 
ATOM 332  C CA  . ILE A 1 110 ? 211.508 263.626 354.118 1.00 35.18  ? 110 ILE A CA  1 
ATOM 333  C C   . ILE A 1 110 ? 210.614 262.426 354.401 1.00 33.68  ? 110 ILE A C   1 
ATOM 334  O O   . ILE A 1 110 ? 211.070 261.278 354.391 1.00 45.25  ? 110 ILE A O   1 
ATOM 335  C CB  . ILE A 1 110 ? 212.095 263.560 352.704 1.00 35.76  ? 110 ILE A CB  1 
ATOM 336  C CG1 . ILE A 1 110 ? 212.797 264.875 352.367 1.00 31.78  ? 110 ILE A CG1 1 
ATOM 337  C CG2 . ILE A 1 110 ? 211.009 263.242 351.687 1.00 35.23  ? 110 ILE A CG2 1 
ATOM 338  C CD1 . ILE A 1 110 ? 213.562 264.847 351.071 1.00 31.87  ? 110 ILE A CD1 1 
ATOM 339  N N   . THR A 1 111 ? 209.331 262.689 354.639 1.00 45.14  ? 111 THR A N   1 
ATOM 340  C CA  . THR A 1 111 ? 208.353 261.644 354.908 1.00 45.74  ? 111 THR A CA  1 
ATOM 341  C C   . THR A 1 111 ? 206.963 262.197 354.631 1.00 48.63  ? 111 THR A C   1 
ATOM 342  O O   . THR A 1 111 ? 206.679 263.360 354.922 1.00 52.00  ? 111 THR A O   1 
ATOM 343  C CB  . THR A 1 111 ? 208.444 261.146 356.352 1.00 47.56  ? 111 THR A CB  1 
ATOM 344  O OG1 . THR A 1 111 ? 207.385 260.216 356.607 1.00 49.82  ? 111 THR A OG1 1 
ATOM 345  C CG2 . THR A 1 111 ? 208.345 262.307 357.329 1.00 44.23  ? 111 THR A CG2 1 
ATOM 346  N N   . TYR A 1 112 ? 206.098 261.350 354.075 1.00 54.83  ? 112 TYR A N   1 
ATOM 347  C CA  . TYR A 1 112 ? 204.742 261.746 353.720 1.00 50.96  ? 112 TYR A CA  1 
ATOM 348  C C   . TYR A 1 112 ? 203.727 261.427 354.805 1.00 48.25  ? 112 TYR A C   1 
ATOM 349  O O   . TYR A 1 112 ? 202.534 261.652 354.601 1.00 55.43  ? 112 TYR A O   1 
ATOM 350  C CB  . TYR A 1 112 ? 204.311 261.073 352.417 1.00 50.50  ? 112 TYR A CB  1 
ATOM 351  C CG  . TYR A 1 112 ? 204.260 259.567 352.480 1.00 45.07  ? 112 TYR A CG  1 
ATOM 352  C CD1 . TYR A 1 112 ? 203.255 258.912 353.171 1.00 47.52  ? 112 TYR A CD1 1 
ATOM 353  C CD2 . TYR A 1 112 ? 205.208 258.798 351.830 1.00 51.60  ? 112 TYR A CD2 1 
ATOM 354  C CE1 . TYR A 1 112 ? 203.205 257.540 353.226 1.00 51.67  ? 112 TYR A CE1 1 
ATOM 355  C CE2 . TYR A 1 112 ? 205.165 257.424 351.878 1.00 52.73  ? 112 TYR A CE2 1 
ATOM 356  C CZ  . TYR A 1 112 ? 204.160 256.800 352.577 1.00 53.02  ? 112 TYR A CZ  1 
ATOM 357  O OH  . TYR A 1 112 ? 204.109 255.428 352.628 1.00 54.18  ? 112 TYR A OH  1 
ATOM 358  N N   . LYS A 1 113 ? 204.165 260.909 355.949 1.00 54.18  ? 113 LYS A N   1 
ATOM 359  C CA  . LYS A 1 113 ? 203.250 260.475 356.994 1.00 53.54  ? 113 LYS A CA  1 
ATOM 360  C C   . LYS A 1 113 ? 202.870 261.601 357.938 1.00 53.55  ? 113 LYS A C   1 
ATOM 361  O O   . LYS A 1 113 ? 202.514 261.343 359.095 1.00 58.52  ? 113 LYS A O   1 
ATOM 362  C CB  . LYS A 1 113 ? 203.858 259.309 357.770 1.00 56.93  ? 113 LYS A CB  1 
ATOM 363  C CG  . LYS A 1 113 ? 204.067 258.069 356.922 1.00 59.15  ? 113 LYS A CG  1 
ATOM 364  C CD  . LYS A 1 113 ? 204.223 256.829 357.775 1.00 60.89  ? 113 LYS A CD  1 
ATOM 365  C CE  . LYS A 1 113 ? 204.263 255.579 356.917 1.00 60.96  ? 113 LYS A CE  1 
ATOM 366  N NZ  . LYS A 1 113 ? 204.333 254.344 357.742 1.00 63.19  ? 113 LYS A NZ  1 
ATOM 367  N N   . ASP A 1 114 ? 202.941 262.847 357.480 1.00 53.87  ? 114 ASP A N   1 
ATOM 368  C CA  . ASP A 1 114 ? 202.438 263.978 358.242 1.00 58.49  ? 114 ASP A CA  1 
ATOM 369  C C   . ASP A 1 114 ? 201.418 264.806 357.482 1.00 60.56  ? 114 ASP A C   1 
ATOM 370  O O   . ASP A 1 114 ? 200.757 265.647 358.098 1.00 59.68  ? 114 ASP A O   1 
ATOM 371  C CB  . ASP A 1 114 ? 203.592 264.889 358.678 1.00 60.89  ? 114 ASP A CB  1 
ATOM 372  C CG  . ASP A 1 114 ? 204.572 264.183 359.592 1.00 67.47  ? 114 ASP A CG  1 
ATOM 373  O OD1 . ASP A 1 114 ? 204.125 263.351 360.409 1.00 62.80  ? 114 ASP A OD1 1 
ATOM 374  O OD2 . ASP A 1 114 ? 205.788 264.455 359.489 1.00 65.57  ? 114 ASP A OD2 1 
ATOM 375  N N   . THR A 1 115 ? 201.270 264.603 356.178 1.00 58.15  ? 115 THR A N   1 
ATOM 376  C CA  . THR A 1 115 ? 200.237 265.257 355.389 1.00 51.00  ? 115 THR A CA  1 
ATOM 377  C C   . THR A 1 115 ? 199.106 264.264 355.176 1.00 52.58  ? 115 THR A C   1 
ATOM 378  O O   . THR A 1 115 ? 199.305 263.214 354.556 1.00 52.45  ? 115 THR A O   1 
ATOM 379  C CB  . THR A 1 115 ? 200.788 265.732 354.047 1.00 53.42  ? 115 THR A CB  1 
ATOM 380  O OG1 . THR A 1 115 ? 201.244 264.604 353.291 1.00 51.66  ? 115 THR A OG1 1 
ATOM 381  C CG2 . THR A 1 115 ? 201.939 266.695 354.255 1.00 55.49  ? 115 THR A CG2 1 
ATOM 382  N N   . VAL A 1 116 ? 197.920 264.601 355.681 1.00 56.65  ? 116 VAL A N   1 
ATOM 383  C CA  . VAL A 1 116 ? 196.805 263.661 355.638 1.00 51.45  ? 116 VAL A CA  1 
ATOM 384  C C   . VAL A 1 116 ? 196.445 263.333 354.197 1.00 52.68  ? 116 VAL A C   1 
ATOM 385  O O   . VAL A 1 116 ? 196.253 262.166 353.839 1.00 56.81  ? 116 VAL A O   1 
ATOM 386  C CB  . VAL A 1 116 ? 195.591 264.232 356.392 1.00 54.45  ? 116 VAL A CB  1 
ATOM 387  C CG1 . VAL A 1 116 ? 194.431 263.251 356.340 1.00 56.34  ? 116 VAL A CG1 1 
ATOM 388  C CG2 . VAL A 1 116 ? 195.950 264.559 357.830 1.00 56.72  ? 116 VAL A CG2 1 
ATOM 389  N N   . GLN A 1 117 ? 196.338 264.358 353.352 1.00 46.34  ? 117 GLN A N   1 
ATOM 390  C CA  . GLN A 1 117 ? 195.760 264.157 352.027 1.00 46.76  ? 117 GLN A CA  1 
ATOM 391  C C   . GLN A 1 117 ? 196.640 263.260 351.169 1.00 44.78  ? 117 GLN A C   1 
ATOM 392  O O   . GLN A 1 117 ? 196.162 262.280 350.584 1.00 49.74  ? 117 GLN A O   1 
ATOM 393  C CB  . GLN A 1 117 ? 195.539 265.506 351.346 1.00 45.01  ? 117 GLN A CB  1 
ATOM 394  C CG  . GLN A 1 117 ? 194.874 266.547 352.225 1.00 47.48  ? 117 GLN A CG  1 
ATOM 395  C CD  . GLN A 1 117 ? 194.280 267.688 351.428 1.00 53.59  ? 117 GLN A CD  1 
ATOM 396  O OE1 . GLN A 1 117 ? 194.489 267.790 350.221 1.00 56.06  ? 117 GLN A OE1 1 
ATOM 397  N NE2 . GLN A 1 117 ? 193.530 268.554 352.100 1.00 51.75  ? 117 GLN A NE2 1 
ATOM 398  N N   . LEU A 1 118 ? 197.933 263.576 351.086 1.00 35.66  ? 118 LEU A N   1 
ATOM 399  C CA  . LEU A 1 118 ? 198.836 262.785 350.259 1.00 38.02  ? 118 LEU A CA  1 
ATOM 400  C C   . LEU A 1 118 ? 198.905 261.348 350.750 1.00 43.26  ? 118 LEU A C   1 
ATOM 401  O O   . LEU A 1 118 ? 198.833 260.401 349.959 1.00 43.25  ? 118 LEU A O   1 
ATOM 402  C CB  . LEU A 1 118 ? 200.225 263.421 350.257 1.00 35.94  ? 118 LEU A CB  1 
ATOM 403  C CG  . LEU A 1 118 ? 201.304 262.689 349.462 1.00 34.13  ? 118 LEU A CG  1 
ATOM 404  C CD1 . LEU A 1 118 ? 200.913 262.557 348.004 1.00 31.87  ? 118 LEU A CD1 1 
ATOM 405  C CD2 . LEU A 1 118 ? 202.623 263.412 349.600 1.00 34.19  ? 118 LEU A CD2 1 
ATOM 406  N N   . ARG A 1 119 ? 199.035 261.165 352.062 1.00 46.31  ? 119 ARG A N   1 
ATOM 407  C CA  . ARG A 1 119 ? 199.103 259.816 352.604 1.00 37.69  ? 119 ARG A CA  1 
ATOM 408  C C   . ARG A 1 119 ? 197.843 259.035 352.268 1.00 43.75  ? 119 ARG A C   1 
ATOM 409  O O   . ARG A 1 119 ? 197.912 257.951 351.682 1.00 48.13  ? 119 ARG A O   1 
ATOM 410  C CB  . ARG A 1 119 ? 199.306 259.873 354.114 1.00 39.98  ? 119 ARG A CB  1 
ATOM 411  C CG  . ARG A 1 119 ? 199.425 258.512 354.742 1.00 51.75  ? 119 ARG A CG  1 
ATOM 412  C CD  . ARG A 1 119 ? 199.665 258.600 356.222 1.00 48.87  ? 119 ARG A CD  1 
ATOM 413  N NE  . ARG A 1 119 ? 199.800 257.274 356.806 1.00 51.93  ? 119 ARG A NE  1 
ATOM 414  C CZ  . ARG A 1 119 ? 199.856 257.033 358.107 1.00 54.74  ? 119 ARG A CZ  1 
ATOM 415  N NH1 . ARG A 1 119 ? 199.799 258.013 358.994 1.00 51.78  ? 119 ARG A NH1 1 
ATOM 416  N NH2 . ARG A 1 119 ? 199.974 255.779 358.529 1.00 53.21  ? 119 ARG A NH2 1 
ATOM 417  N N   . ARG A 1 120 ? 196.677 259.590 352.598 1.00 45.48  ? 120 ARG A N   1 
ATOM 418  C CA  . ARG A 1 120 ? 195.431 258.877 352.351 1.00 41.00  ? 120 ARG A CA  1 
ATOM 419  C C   . ARG A 1 120 ? 195.282 258.531 350.879 1.00 36.39  ? 120 ARG A C   1 
ATOM 420  O O   . ARG A 1 120 ? 194.742 257.475 350.535 1.00 40.82  ? 120 ARG A O   1 
ATOM 421  C CB  . ARG A 1 120 ? 194.241 259.705 352.824 1.00 38.62  ? 120 ARG A CB  1 
ATOM 422  C CG  . ARG A 1 120 ? 192.942 258.918 352.892 1.00 44.12  ? 120 ARG A CG  1 
ATOM 423  C CD  . ARG A 1 120 ? 191.745 259.825 353.067 1.00 51.92  ? 120 ARG A CD  1 
ATOM 424  N NE  . ARG A 1 120 ? 190.522 259.082 353.343 1.00 46.66  ? 120 ARG A NE  1 
ATOM 425  C CZ  . ARG A 1 120 ? 189.837 258.399 352.436 1.00 47.51  ? 120 ARG A CZ  1 
ATOM 426  N NH1 . ARG A 1 120 ? 190.243 258.310 351.181 1.00 46.73  ? 120 ARG A NH1 1 
ATOM 427  N NH2 . ARG A 1 120 ? 188.715 257.786 352.799 1.00 49.80  ? 120 ARG A NH2 1 
ATOM 428  N N   . LYS A 1 121 ? 195.743 259.406 349.990 1.00 37.18  ? 121 LYS A N   1 
ATOM 429  C CA  . LYS A 1 121 ? 195.700 259.076 348.575 1.00 34.70  ? 121 LYS A CA  1 
ATOM 430  C C   . LYS A 1 121 ? 196.728 258.024 348.191 1.00 34.07  ? 121 LYS A C   1 
ATOM 431  O O   . LYS A 1 121 ? 196.570 257.378 347.152 1.00 40.05  ? 121 LYS A O   1 
ATOM 432  C CB  . LYS A 1 121 ? 195.911 260.329 347.727 1.00 43.12  ? 121 LYS A CB  1 
ATOM 433  C CG  . LYS A 1 121 ? 194.777 261.326 347.815 1.00 42.31  ? 121 LYS A CG  1 
ATOM 434  C CD  . LYS A 1 121 ? 194.727 262.225 346.595 1.00 43.78  ? 121 LYS A CD  1 
ATOM 435  C CE  . LYS A 1 121 ? 195.967 263.091 346.478 1.00 42.70  ? 121 LYS A CE  1 
ATOM 436  N NZ  . LYS A 1 121 ? 195.911 263.948 345.261 1.00 47.00  ? 121 LYS A NZ  1 
ATOM 437  N N   . LEU A 1 122 ? 197.779 257.842 348.991 1.00 45.23  ? 122 LEU A N   1 
ATOM 438  C CA  . LEU A 1 122 ? 198.770 256.806 348.715 1.00 38.18  ? 122 LEU A CA  1 
ATOM 439  C C   . LEU A 1 122 ? 198.379 255.445 349.269 1.00 36.34  ? 122 LEU A C   1 
ATOM 440  O O   . LEU A 1 122 ? 198.759 254.423 348.692 1.00 41.82  ? 122 LEU A O   1 
ATOM 441  C CB  . LEU A 1 122 ? 200.130 257.201 349.293 1.00 41.77  ? 122 LEU A CB  1 
ATOM 442  C CG  . LEU A 1 122 ? 201.012 258.109 348.436 1.00 36.92  ? 122 LEU A CG  1 
ATOM 443  C CD1 . LEU A 1 122 ? 202.244 258.507 349.210 1.00 32.35  ? 122 LEU A CD1 1 
ATOM 444  C CD2 . LEU A 1 122 ? 201.393 257.422 347.141 1.00 30.19  ? 122 LEU A CD2 1 
ATOM 445  N N   . GLU A 1 123 ? 197.623 255.404 350.361 1.00 46.30  ? 123 GLU A N   1 
ATOM 446  C CA  . GLU A 1 123 ? 197.231 254.147 350.984 1.00 44.51  ? 123 GLU A CA  1 
ATOM 447  C C   . GLU A 1 123 ? 196.196 253.379 350.175 1.00 38.09  ? 123 GLU A C   1 
ATOM 448  O O   . GLU A 1 123 ? 195.863 252.252 350.543 1.00 46.44  ? 123 GLU A O   1 
ATOM 449  C CB  . GLU A 1 123 ? 196.689 254.405 352.390 1.00 45.39  ? 123 GLU A CB  1 
ATOM 450  C CG  . GLU A 1 123 ? 197.633 255.185 353.289 1.00 45.71  ? 123 GLU A CG  1 
ATOM 451  C CD  . GLU A 1 123 ? 198.923 254.459 353.572 1.00 50.49  ? 123 GLU A CD  1 
ATOM 452  O OE1 . GLU A 1 123 ? 199.059 253.297 353.144 1.00 55.44  ? 123 GLU A OE1 1 
ATOM 453  O OE2 . GLU A 1 123 ? 199.804 255.047 354.232 1.00 49.23  ? 123 GLU A OE2 1 
ATOM 454  N N   . PHE A 1 124 ? 195.664 253.958 349.101 1.00 38.65  ? 124 PHE A N   1 
ATOM 455  C CA  . PHE A 1 124 ? 194.830 253.186 348.190 1.00 35.62  ? 124 PHE A CA  1 
ATOM 456  C C   . PHE A 1 124 ? 195.585 252.012 347.596 1.00 35.68  ? 124 PHE A C   1 
ATOM 457  O O   . PHE A 1 124 ? 194.958 251.063 347.120 1.00 45.92  ? 124 PHE A O   1 
ATOM 458  C CB  . PHE A 1 124 ? 194.316 254.071 347.056 1.00 45.01  ? 124 PHE A CB  1 
ATOM 459  C CG  . PHE A 1 124 ? 193.114 254.885 347.413 1.00 39.13  ? 124 PHE A CG  1 
ATOM 460  C CD1 . PHE A 1 124 ? 193.198 255.890 348.355 1.00 42.10  ? 124 PHE A CD1 1 
ATOM 461  C CD2 . PHE A 1 124 ? 191.905 254.658 346.792 1.00 41.59  ? 124 PHE A CD2 1 
ATOM 462  C CE1 . PHE A 1 124 ? 192.095 256.643 348.679 1.00 42.88  ? 124 PHE A CE1 1 
ATOM 463  C CE2 . PHE A 1 124 ? 190.799 255.408 347.113 1.00 46.66  ? 124 PHE A CE2 1 
ATOM 464  C CZ  . PHE A 1 124 ? 190.895 256.403 348.057 1.00 44.11  ? 124 PHE A CZ  1 
ATOM 465  N N   . PHE A 1 125 ? 196.912 252.062 347.599 1.00 36.07  ? 125 PHE A N   1 
ATOM 466  C CA  . PHE A 1 125 ? 197.747 251.063 346.958 1.00 38.63  ? 125 PHE A CA  1 
ATOM 467  C C   . PHE A 1 125 ? 198.800 250.592 347.949 1.00 42.44  ? 125 PHE A C   1 
ATOM 468  O O   . PHE A 1 125 ? 198.892 251.091 349.072 1.00 43.62  ? 125 PHE A O   1 
ATOM 469  C CB  . PHE A 1 125 ? 198.384 251.634 345.690 1.00 25.77  ? 125 PHE A CB  1 
ATOM 470  C CG  . PHE A 1 125 ? 197.385 252.219 344.741 1.00 34.58  ? 125 PHE A CG  1 
ATOM 471  C CD1 . PHE A 1 125 ? 196.893 253.494 344.934 1.00 35.19  ? 125 PHE A CD1 1 
ATOM 472  C CD2 . PHE A 1 125 ? 196.922 251.488 343.666 1.00 38.61  ? 125 PHE A CD2 1 
ATOM 473  C CE1 . PHE A 1 125 ? 195.968 254.030 344.070 1.00 39.04  ? 125 PHE A CE1 1 
ATOM 474  C CE2 . PHE A 1 125 ? 195.999 252.017 342.800 1.00 35.08  ? 125 PHE A CE2 1 
ATOM 475  C CZ  . PHE A 1 125 ? 195.520 253.289 343.002 1.00 41.59  ? 125 PHE A CZ  1 
ATOM 476  N N   . THR A 1 126 ? 199.595 249.610 347.535 1.00 38.02  ? 126 THR A N   1 
ATOM 477  C CA  . THR A 1 126 ? 200.601 249.020 348.409 1.00 42.09  ? 126 THR A CA  1 
ATOM 478  C C   . THR A 1 126 ? 202.026 249.224 347.920 1.00 44.33  ? 126 THR A C   1 
ATOM 479  O O   . THR A 1 126 ? 202.918 249.446 348.738 1.00 44.79  ? 126 THR A O   1 
ATOM 480  C CB  . THR A 1 126 ? 200.322 247.522 348.590 1.00 47.37  ? 126 THR A CB  1 
ATOM 481  O OG1 . THR A 1 126 ? 201.069 247.023 349.705 1.00 48.42  ? 126 THR A OG1 1 
ATOM 482  C CG2 . THR A 1 126 ? 200.688 246.741 347.346 1.00 45.84  ? 126 THR A CG2 1 
ATOM 483  N N   . TYR A 1 127 ? 202.267 249.177 346.613 1.00 35.05  ? 127 TYR A N   1 
ATOM 484  C CA  . TYR A 1 127 ? 203.577 249.431 346.035 1.00 31.40  ? 127 TYR A CA  1 
ATOM 485  C C   . TYR A 1 127 ? 203.521 250.653 345.129 1.00 36.50  ? 127 TYR A C   1 
ATOM 486  O O   . TYR A 1 127 ? 202.541 250.877 344.415 1.00 49.42  ? 127 TYR A O   1 
ATOM 487  C CB  . TYR A 1 127 ? 204.072 248.220 345.241 1.00 38.77  ? 127 TYR A CB  1 
ATOM 488  C CG  . TYR A 1 127 ? 204.106 246.938 346.037 1.00 43.96  ? 127 TYR A CG  1 
ATOM 489  C CD1 . TYR A 1 127 ? 204.447 246.941 347.378 1.00 44.45  ? 127 TYR A CD1 1 
ATOM 490  C CD2 . TYR A 1 127 ? 203.792 245.726 345.446 1.00 38.90  ? 127 TYR A CD2 1 
ATOM 491  C CE1 . TYR A 1 127 ? 204.477 245.777 348.105 1.00 41.04  ? 127 TYR A CE1 1 
ATOM 492  C CE2 . TYR A 1 127 ? 203.819 244.559 346.168 1.00 40.40  ? 127 TYR A CE2 1 
ATOM 493  C CZ  . TYR A 1 127 ? 204.161 244.590 347.497 1.00 44.77  ? 127 TYR A CZ  1 
ATOM 494  O OH  . TYR A 1 127 ? 204.190 243.425 348.224 1.00 48.42  ? 127 TYR A OH  1 
ATOM 495  N N   . SER A 1 128 ? 204.602 251.432 345.149 1.00 36.97  ? 128 SER A N   1 
ATOM 496  C CA  . SER A 1 128 ? 204.624 252.738 344.504 1.00 27.91  ? 128 SER A CA  1 
ATOM 497  C C   . SER A 1 128 ? 206.020 253.044 343.982 1.00 35.69  ? 128 SER A C   1 
ATOM 498  O O   . SER A 1 128 ? 207.016 252.501 344.462 1.00 49.40  ? 128 SER A O   1 
ATOM 499  C CB  . SER A 1 128 ? 204.176 253.828 345.479 1.00 33.29  ? 128 SER A CB  1 
ATOM 500  O OG  . SER A 1 128 ? 204.522 255.111 344.999 1.00 46.15  ? 128 SER A OG  1 
ATOM 501  N N   . ARG A 1 129 ? 206.073 253.931 342.989 1.00 40.79  ? 129 ARG A N   1 
ATOM 502  C CA  . ARG A 1 129 ? 207.317 254.481 342.461 1.00 33.28  ? 129 ARG A CA  1 
ATOM 503  C C   . ARG A 1 129 ? 207.058 255.912 342.024 1.00 34.58  ? 129 ARG A C   1 
ATOM 504  O O   . ARG A 1 129 ? 206.022 256.186 341.418 1.00 45.79  ? 129 ARG A O   1 
ATOM 505  C CB  . ARG A 1 129 ? 207.834 253.693 341.257 1.00 29.10  ? 129 ARG A CB  1 
ATOM 506  C CG  . ARG A 1 129 ? 208.579 252.434 341.584 1.00 42.98  ? 129 ARG A CG  1 
ATOM 507  C CD  . ARG A 1 129 ? 208.957 251.703 340.315 1.00 40.78  ? 129 ARG A CD  1 
ATOM 508  N NE  . ARG A 1 129 ? 209.823 252.496 339.452 1.00 36.37  ? 129 ARG A NE  1 
ATOM 509  C CZ  . ARG A 1 129 ? 211.145 252.407 339.416 1.00 38.36  ? 129 ARG A CZ  1 
ATOM 510  N NH1 . ARG A 1 129 ? 211.807 251.575 340.202 1.00 40.11  ? 129 ARG A NH1 1 
ATOM 511  N NH2 . ARG A 1 129 ? 211.823 253.171 338.566 1.00 44.12  ? 129 ARG A NH2 1 
ATOM 512  N N   . PHE A 1 130 ? 207.995 256.818 342.306 1.00 33.74  ? 130 PHE A N   1 
ATOM 513  C CA  . PHE A 1 130 ? 207.839 258.186 341.829 1.00 25.23  ? 130 PHE A CA  1 
ATOM 514  C C   . PHE A 1 130 ? 209.089 258.998 342.128 1.00 32.99  ? 130 PHE A C   1 
ATOM 515  O O   . PHE A 1 130 ? 209.854 258.658 343.031 1.00 41.32  ? 130 PHE A O   1 
ATOM 516  C CB  . PHE A 1 130 ? 206.624 258.863 342.472 1.00 33.01  ? 130 PHE A CB  1 
ATOM 517  C CG  . PHE A 1 130 ? 206.718 258.997 343.959 1.00 34.07  ? 130 PHE A CG  1 
ATOM 518  C CD1 . PHE A 1 130 ? 207.360 260.074 344.530 1.00 29.54  ? 130 PHE A CD1 1 
ATOM 519  C CD2 . PHE A 1 130 ? 206.150 258.056 344.785 1.00 33.04  ? 130 PHE A CD2 1 
ATOM 520  C CE1 . PHE A 1 130 ? 207.437 260.204 345.891 1.00 28.06  ? 130 PHE A CE1 1 
ATOM 521  C CE2 . PHE A 1 130 ? 206.223 258.182 346.148 1.00 35.99  ? 130 PHE A CE2 1 
ATOM 522  C CZ  . PHE A 1 130 ? 206.868 259.257 346.702 1.00 30.61  ? 130 PHE A CZ  1 
ATOM 523  N N   . ASP A 1 131 ? 209.278 260.073 341.363 1.00 40.71  ? 131 ASP A N   1 
ATOM 524  C CA  . ASP A 1 131 ? 210.298 261.076 341.638 1.00 27.75  ? 131 ASP A CA  1 
ATOM 525  C C   . ASP A 1 131 ? 209.678 262.248 342.386 1.00 23.84  ? 131 ASP A C   1 
ATOM 526  O O   . ASP A 1 131 ? 208.462 262.425 342.388 1.00 42.86  ? 131 ASP A O   1 
ATOM 527  C CB  . ASP A 1 131 ? 210.929 261.568 340.340 1.00 25.92  ? 131 ASP A CB  1 
ATOM 528  C CG  . ASP A 1 131 ? 211.068 260.472 339.314 1.00 41.59  ? 131 ASP A CG  1 
ATOM 529  O OD1 . ASP A 1 131 ? 210.562 259.361 339.565 1.00 46.08  ? 131 ASP A OD1 1 
ATOM 530  O OD2 . ASP A 1 131 ? 211.681 260.719 338.255 1.00 42.37  ? 131 ASP A OD2 1 
ATOM 531  N N   . MET A 1 132 ? 210.520 263.057 343.012 1.00 24.90  ? 132 MET A N   1 
ATOM 532  C CA  . MET A 1 132 ? 210.054 264.217 343.755 1.00 21.63  ? 132 MET A CA  1 
ATOM 533  C C   . MET A 1 132 ? 210.476 265.508 343.063 1.00 34.57  ? 132 MET A C   1 
ATOM 534  O O   . MET A 1 132 ? 211.542 265.593 342.456 1.00 46.96  ? 132 MET A O   1 
ATOM 535  C CB  . MET A 1 132 ? 210.599 264.197 345.183 1.00 33.09  ? 132 MET A CB  1 
ATOM 536  C CG  . MET A 1 132 ? 209.890 263.223 346.096 1.00 41.12  ? 132 MET A CG  1 
ATOM 537  S SD  . MET A 1 132 ? 210.613 263.128 347.739 1.00 58.77  ? 132 MET A SD  1 
ATOM 538  C CE  . MET A 1 132 ? 211.924 261.943 347.448 1.00 37.85  ? 132 MET A CE  1 
ATOM 539  N N   . GLU A 1 133 ? 209.614 266.517 343.157 1.00 33.06  ? 133 GLU A N   1 
ATOM 540  C CA  . GLU A 1 133 ? 209.939 267.874 342.732 1.00 22.82  ? 133 GLU A CA  1 
ATOM 541  C C   . GLU A 1 133 ? 209.698 268.794 343.915 1.00 19.90  ? 133 GLU A C   1 
ATOM 542  O O   . GLU A 1 133 ? 208.566 268.911 344.385 1.00 37.50  ? 133 GLU A O   1 
ATOM 543  C CB  . GLU A 1 133 ? 209.086 268.294 341.534 1.00 31.59  ? 133 GLU A CB  1 
ATOM 544  C CG  . GLU A 1 133 ? 209.528 269.572 340.855 1.00 39.11  ? 133 GLU A CG  1 
ATOM 545  C CD  . GLU A 1 133 ? 208.460 270.156 339.941 1.00 47.51  ? 133 GLU A CD  1 
ATOM 546  O OE1 . GLU A 1 133 ? 207.374 270.514 340.442 1.00 38.42  ? 133 GLU A OE1 1 
ATOM 547  O OE2 . GLU A 1 133 ? 208.707 270.260 338.721 1.00 49.67  ? 133 GLU A OE2 1 
ATOM 548  N N   . LEU A 1 134 ? 210.754 269.435 344.401 1.00 14.02  ? 134 LEU A N   1 
ATOM 549  C CA  . LEU A 1 134 ? 210.696 270.230 345.619 1.00 16.22  ? 134 LEU A CA  1 
ATOM 550  C C   . LEU A 1 134 ? 210.874 271.699 345.281 1.00 20.50  ? 134 LEU A C   1 
ATOM 551  O O   . LEU A 1 134 ? 211.766 272.055 344.505 1.00 38.18  ? 134 LEU A O   1 
ATOM 552  C CB  . LEU A 1 134 ? 211.776 269.789 346.605 1.00 27.23  ? 134 LEU A CB  1 
ATOM 553  C CG  . LEU A 1 134 ? 211.672 268.358 347.126 1.00 24.76  ? 134 LEU A CG  1 
ATOM 554  C CD1 . LEU A 1 134 ? 212.996 267.903 347.694 1.00 25.70  ? 134 LEU A CD1 1 
ATOM 555  C CD2 . LEU A 1 134 ? 210.589 268.265 348.172 1.00 34.75  ? 134 LEU A CD2 1 
ATOM 556  N N   . THR A 1 135 ? 210.022 272.544 345.858 1.00 17.30  ? 135 THR A N   1 
ATOM 557  C CA  . THR A 1 135 ? 210.120 273.988 345.713 1.00 25.20  ? 135 THR A CA  1 
ATOM 558  C C   . THR A 1 135 ? 210.098 274.626 347.093 1.00 23.11  ? 135 THR A C   1 
ATOM 559  O O   . THR A 1 135 ? 209.459 274.118 348.013 1.00 23.59  ? 135 THR A O   1 
ATOM 560  C CB  . THR A 1 135 ? 208.979 274.551 344.856 1.00 19.62  ? 135 THR A CB  1 
ATOM 561  O OG1 . THR A 1 135 ? 208.923 273.853 343.608 1.00 17.66  ? 135 THR A OG1 1 
ATOM 562  C CG2 . THR A 1 135 ? 209.192 276.021 344.580 1.00 16.61  ? 135 THR A CG2 1 
ATOM 563  N N   . PHE A 1 136 ? 210.806 275.740 347.238 1.00 16.26  ? 136 PHE A N   1 
ATOM 564  C CA  . PHE A 1 136 ? 210.981 276.387 348.532 1.00 16.99  ? 136 PHE A CA  1 
ATOM 565  C C   . PHE A 1 136 ? 210.515 277.830 348.460 1.00 22.94  ? 136 PHE A C   1 
ATOM 566  O O   . PHE A 1 136 ? 210.979 278.590 347.608 1.00 39.14  ? 136 PHE A O   1 
ATOM 567  C CB  . PHE A 1 136 ? 212.444 276.328 348.971 1.00 25.01  ? 136 PHE A CB  1 
ATOM 568  C CG  . PHE A 1 136 ? 213.017 274.947 348.946 1.00 32.08  ? 136 PHE A CG  1 
ATOM 569  C CD1 . PHE A 1 136 ? 213.554 274.429 347.782 1.00 29.64  ? 136 PHE A CD1 1 
ATOM 570  C CD2 . PHE A 1 136 ? 213.001 274.158 350.077 1.00 26.88  ? 136 PHE A CD2 1 
ATOM 571  C CE1 . PHE A 1 136 ? 214.066 273.163 347.751 1.00 22.20  ? 136 PHE A CE1 1 
ATOM 572  C CE2 . PHE A 1 136 ? 213.515 272.888 350.048 1.00 25.38  ? 136 PHE A CE2 1 
ATOM 573  C CZ  . PHE A 1 136 ? 214.044 272.388 348.883 1.00 27.38  ? 136 PHE A CZ  1 
ATOM 574  N N   . VAL A 1 137 ? 209.611 278.208 349.357 1.00 25.15  ? 137 VAL A N   1 
ATOM 575  C CA  . VAL A 1 137 ? 209.101 279.572 349.435 1.00 33.93  ? 137 VAL A CA  1 
ATOM 576  C C   . VAL A 1 137 ? 209.582 280.160 350.752 1.00 26.32  ? 137 VAL A C   1 
ATOM 577  O O   . VAL A 1 137 ? 209.182 279.705 351.827 1.00 31.20  ? 137 VAL A O   1 
ATOM 578  C CB  . VAL A 1 137 ? 207.571 279.615 349.323 1.00 27.20  ? 137 VAL A CB  1 
ATOM 579  C CG1 . VAL A 1 137 ? 207.059 281.033 349.486 1.00 21.45  ? 137 VAL A CG1 1 
ATOM 580  C CG2 . VAL A 1 137 ? 207.122 279.036 347.993 1.00 24.80  ? 137 VAL A CG2 1 
ATOM 581  N N   . VAL A 1 138 ? 210.430 281.180 350.674 1.00 25.91  ? 138 VAL A N   1 
ATOM 582  C CA  . VAL A 1 138 ? 211.104 281.748 351.834 1.00 25.59  ? 138 VAL A CA  1 
ATOM 583  C C   . VAL A 1 138 ? 210.494 283.103 352.149 1.00 34.63  ? 138 VAL A C   1 
ATOM 584  O O   . VAL A 1 138 ? 210.229 283.903 351.244 1.00 36.11  ? 138 VAL A O   1 
ATOM 585  C CB  . VAL A 1 138 ? 212.619 281.884 351.591 1.00 22.08  ? 138 VAL A CB  1 
ATOM 586  C CG1 . VAL A 1 138 ? 213.312 282.369 352.846 1.00 30.25  ? 138 VAL A CG1 1 
ATOM 587  C CG2 . VAL A 1 138 ? 213.202 280.570 351.116 1.00 29.08  ? 138 VAL A CG2 1 
ATOM 588  N N   . THR A 1 139 ? 210.260 283.356 353.434 1.00 35.06  ? 139 THR A N   1 
ATOM 589  C CA  . THR A 1 139 ? 209.805 284.660 353.891 1.00 31.68  ? 139 THR A CA  1 
ATOM 590  C C   . THR A 1 139 ? 210.565 285.014 355.158 1.00 36.49  ? 139 THR A C   1 
ATOM 591  O O   . THR A 1 139 ? 211.077 284.139 355.855 1.00 45.42  ? 139 THR A O   1 
ATOM 592  C CB  . THR A 1 139 ? 208.293 284.683 354.145 1.00 38.21  ? 139 THR A CB  1 
ATOM 593  O OG1 . THR A 1 139 ? 207.962 283.764 355.189 1.00 46.32  ? 139 THR A OG1 1 
ATOM 594  C CG2 . THR A 1 139 ? 207.539 284.302 352.888 1.00 38.29  ? 139 THR A CG2 1 
ATOM 595  N N   . ALA A 1 140 ? 210.647 286.309 355.447 1.00 39.25  ? 140 ALA A N   1 
ATOM 596  C CA  . ALA A 1 140 ? 211.434 286.798 356.568 1.00 41.55  ? 140 ALA A CA  1 
ATOM 597  C C   . ALA A 1 140 ? 210.724 287.974 357.215 1.00 41.71  ? 140 ALA A C   1 
ATOM 598  O O   . ALA A 1 140 ? 209.792 288.551 356.654 1.00 42.80  ? 140 ALA A O   1 
ATOM 599  C CB  . ALA A 1 140 ? 212.842 287.212 356.131 1.00 41.35  ? 140 ALA A CB  1 
ATOM 600  N N   . ASN A 1 141 ? 211.167 288.317 358.421 1.00 54.06  ? 141 ASN A N   1 
ATOM 601  C CA  . ASN A 1 141 ? 210.597 289.463 359.111 1.00 57.48  ? 141 ASN A CA  1 
ATOM 602  C C   . ASN A 1 141 ? 211.492 289.866 360.272 1.00 58.65  ? 141 ASN A C   1 
ATOM 603  O O   . ASN A 1 141 ? 212.159 289.026 360.885 1.00 61.95  ? 141 ASN A O   1 
ATOM 604  C CB  . ASN A 1 141 ? 209.189 289.157 359.622 1.00 56.99  ? 141 ASN A CB  1 
ATOM 605  C CG  . ASN A 1 141 ? 209.202 288.418 360.937 1.00 58.44  ? 141 ASN A CG  1 
ATOM 606  O OD1 . ASN A 1 141 ? 209.276 287.192 360.973 1.00 58.47  ? 141 ASN A OD1 1 
ATOM 607  N ND2 . ASN A 1 141 ? 209.133 289.161 362.031 1.00 59.93  ? 141 ASN A ND2 1 
ATOM 608  N N   . PHE A 1 142 ? 211.489 291.164 360.567 1.00 58.04  ? 142 PHE A N   1 
ATOM 609  C CA  . PHE A 1 142 ? 212.121 291.663 361.779 1.00 61.00  ? 142 PHE A CA  1 
ATOM 610  C C   . PHE A 1 142 ? 211.280 291.289 362.989 1.00 66.52  ? 142 PHE A C   1 
ATOM 611  O O   . PHE A 1 142 ? 210.048 291.280 362.927 1.00 70.53  ? 142 PHE A O   1 
ATOM 612  C CB  . PHE A 1 142 ? 212.286 293.178 361.720 1.00 63.55  ? 142 PHE A CB  1 
ATOM 613  C CG  . PHE A 1 142 ? 213.178 293.650 360.613 1.00 66.05  ? 142 PHE A CG  1 
ATOM 614  C CD1 . PHE A 1 142 ? 214.546 293.476 360.688 1.00 64.48  ? 142 PHE A CD1 1 
ATOM 615  C CD2 . PHE A 1 142 ? 212.652 294.281 359.505 1.00 64.45  ? 142 PHE A CD2 1 
ATOM 616  C CE1 . PHE A 1 142 ? 215.366 293.909 359.675 1.00 65.64  ? 142 PHE A CE1 1 
ATOM 617  C CE2 . PHE A 1 142 ? 213.468 294.717 358.490 1.00 63.44  ? 142 PHE A CE2 1 
ATOM 618  C CZ  . PHE A 1 142 ? 214.826 294.531 358.574 1.00 63.89  ? 142 PHE A CZ  1 
ATOM 619  N N   . THR A 1 143 ? 211.949 290.986 364.098 1.00 68.56  ? 143 THR A N   1 
ATOM 620  C CA  . THR A 1 143 ? 211.282 290.517 365.305 1.00 71.72  ? 143 THR A CA  1 
ATOM 621  C C   . THR A 1 143 ? 211.427 291.498 366.463 1.00 69.40  ? 143 THR A C   1 
ATOM 622  O O   . THR A 1 143 ? 211.388 291.097 367.627 1.00 71.03  ? 143 THR A O   1 
ATOM 623  C CB  . THR A 1 143 ? 211.817 289.146 365.709 1.00 71.68  ? 143 THR A CB  1 
ATOM 624  O OG1 . THR A 1 143 ? 213.238 289.213 365.856 1.00 72.29  ? 143 THR A OG1 1 
ATOM 625  C CG2 . THR A 1 143 ? 211.468 288.110 364.658 1.00 67.74  ? 143 THR A CG2 1 
ATOM 626  N N   . GLU A 1 144 ? 211.598 292.782 366.163 1.00 80.32  ? 144 GLU A N   1 
ATOM 627  C CA  . GLU A 1 144 ? 211.682 293.785 367.214 1.00 83.62  ? 144 GLU A CA  1 
ATOM 628  C C   . GLU A 1 144 ? 211.732 295.166 366.576 1.00 85.69  ? 144 GLU A C   1 
ATOM 629  O O   . GLU A 1 144 ? 212.186 295.321 365.439 1.00 84.75  ? 144 GLU A O   1 
ATOM 630  C CB  . GLU A 1 144 ? 212.906 293.545 368.108 1.00 83.62  ? 144 GLU A CB  1 
ATOM 631  C CG  . GLU A 1 144 ? 213.178 294.637 369.128 1.00 85.62  ? 144 GLU A CG  1 
ATOM 632  C CD  . GLU A 1 144 ? 213.965 295.790 368.547 1.00 87.38  ? 144 GLU A CD  1 
ATOM 633  O OE1 . GLU A 1 144 ? 214.336 295.707 367.359 1.00 87.28  ? 144 GLU A OE1 1 
ATOM 634  O OE2 . GLU A 1 144 ? 214.207 296.778 369.271 1.00 89.11  ? 144 GLU A OE2 1 
ATOM 635  N N   . THR A 1 145 ? 211.270 296.164 367.328 1.00 93.08  ? 145 THR A N   1 
ATOM 636  C CA  . THR A 1 145 ? 211.207 297.548 366.856 1.00 94.64  ? 145 THR A CA  1 
ATOM 637  C C   . THR A 1 145 ? 212.553 298.216 367.105 1.00 91.46  ? 145 THR A C   1 
ATOM 638  O O   . THR A 1 145 ? 212.767 298.838 368.149 1.00 90.35  ? 145 THR A O   1 
ATOM 639  C CB  . THR A 1 145 ? 210.087 298.309 367.560 1.00 94.09  ? 145 THR A CB  1 
ATOM 640  O OG1 . THR A 1 145 ? 210.196 298.129 368.978 1.00 93.83  ? 145 THR A OG1 1 
ATOM 641  C CG2 . THR A 1 145 ? 208.725 297.824 367.092 1.00 92.57  ? 145 THR A CG2 1 
ATOM 642  N N   . ASN A 1 146 ? 213.463 298.094 366.142 1.00 96.43  ? 146 ASN A N   1 
ATOM 643  C CA  . ASN A 1 146 ? 214.749 298.774 366.196 1.00 100.30 ? 146 ASN A CA  1 
ATOM 644  C C   . ASN A 1 146 ? 215.008 299.448 364.860 1.00 99.98  ? 146 ASN A C   1 
ATOM 645  O O   . ASN A 1 146 ? 214.609 298.939 363.809 1.00 96.14  ? 146 ASN A O   1 
ATOM 646  C CB  . ASN A 1 146 ? 215.892 297.805 366.530 1.00 99.50  ? 146 ASN A CB  1 
ATOM 647  C CG  . ASN A 1 146 ? 217.260 298.445 366.405 1.00 98.34  ? 146 ASN A CG  1 
ATOM 648  O OD1 . ASN A 1 146 ? 217.984 298.206 365.439 1.00 97.26  ? 146 ASN A OD1 1 
ATOM 649  N ND2 . ASN A 1 146 ? 217.620 299.264 367.385 1.00 96.78  ? 146 ASN A ND2 1 
ATOM 650  N N   . ASN A 1 147 ? 215.669 300.605 364.912 1.00 106.05 ? 147 ASN A N   1 
ATOM 651  C CA  . ASN A 1 147 ? 216.014 301.324 363.694 1.00 105.49 ? 147 ASN A CA  1 
ATOM 652  C C   . ASN A 1 147 ? 217.145 300.651 362.930 1.00 106.81 ? 147 ASN A C   1 
ATOM 653  O O   . ASN A 1 147 ? 217.234 300.816 361.709 1.00 107.52 ? 147 ASN A O   1 
ATOM 654  C CB  . ASN A 1 147 ? 216.395 302.764 364.032 1.00 105.82 ? 147 ASN A CB  1 
ATOM 655  C CG  . ASN A 1 147 ? 216.987 303.499 362.851 1.00 105.64 ? 147 ASN A CG  1 
ATOM 656  O OD1 . ASN A 1 147 ? 216.308 303.753 361.858 1.00 107.76 ? 147 ASN A OD1 1 
ATOM 657  N ND2 . ASN A 1 147 ? 218.259 303.847 362.953 1.00 101.72 ? 147 ASN A ND2 1 
ATOM 658  N N   . GLY A 1 148 ? 218.007 299.904 363.614 1.00 99.17  ? 148 GLY A N   1 
ATOM 659  C CA  . GLY A 1 148 ? 219.025 299.147 362.909 1.00 93.83  ? 148 GLY A CA  1 
ATOM 660  C C   . GLY A 1 148 ? 218.390 298.179 361.928 1.00 92.57  ? 148 GLY A C   1 
ATOM 661  O O   . GLY A 1 148 ? 217.325 297.614 362.184 1.00 92.88  ? 148 GLY A O   1 
ATOM 662  N N   . HIS A 1 149 ? 219.049 297.998 360.788 1.00 81.91  ? 149 HIS A N   1 
ATOM 663  C CA  . HIS A 1 149 ? 218.514 297.200 359.697 1.00 82.45  ? 149 HIS A CA  1 
ATOM 664  C C   . HIS A 1 149 ? 219.519 296.119 359.328 1.00 78.52  ? 149 HIS A C   1 
ATOM 665  O O   . HIS A 1 149 ? 220.537 295.929 359.998 1.00 78.79  ? 149 HIS A O   1 
ATOM 666  C CB  . HIS A 1 149 ? 218.176 298.088 358.494 1.00 82.30  ? 149 HIS A CB  1 
ATOM 667  C CG  . HIS A 1 149 ? 217.220 299.191 358.821 1.00 86.64  ? 149 HIS A CG  1 
ATOM 668  N ND1 . HIS A 1 149 ? 217.372 300.475 358.346 1.00 88.53  ? 149 HIS A ND1 1 
ATOM 669  C CD2 . HIS A 1 149 ? 216.101 299.202 359.584 1.00 83.92  ? 149 HIS A CD2 1 
ATOM 670  C CE1 . HIS A 1 149 ? 216.389 301.230 358.801 1.00 87.25  ? 149 HIS A CE1 1 
ATOM 671  N NE2 . HIS A 1 149 ? 215.603 300.482 359.554 1.00 85.45  ? 149 HIS A NE2 1 
ATOM 672  N N   . ALA A 1 150 ? 219.215 295.398 358.253 1.00 66.42  ? 150 ALA A N   1 
ATOM 673  C CA  . ALA A 1 150 ? 220.041 294.295 357.795 1.00 71.01  ? 150 ALA A CA  1 
ATOM 674  C C   . ALA A 1 150 ? 220.160 294.356 356.283 1.00 65.44  ? 150 ALA A C   1 
ATOM 675  O O   . ALA A 1 150 ? 219.302 294.921 355.601 1.00 64.69  ? 150 ALA A O   1 
ATOM 676  C CB  . ALA A 1 150 ? 219.455 292.945 358.220 1.00 68.39  ? 150 ALA A CB  1 
ATOM 677  N N   . LEU A 1 151 ? 221.235 293.776 355.764 1.00 50.75  ? 151 LEU A N   1 
ATOM 678  C CA  . LEU A 1 151 ? 221.417 293.662 354.330 1.00 47.22  ? 151 LEU A CA  1 
ATOM 679  C C   . LEU A 1 151 ? 220.678 292.429 353.819 1.00 51.95  ? 151 LEU A C   1 
ATOM 680  O O   . LEU A 1 151 ? 220.018 291.712 354.572 1.00 58.87  ? 151 LEU A O   1 
ATOM 681  C CB  . LEU A 1 151 ? 222.904 293.609 353.988 1.00 48.84  ? 151 LEU A CB  1 
ATOM 682  C CG  . LEU A 1 151 ? 223.682 294.890 354.288 1.00 54.34  ? 151 LEU A CG  1 
ATOM 683  C CD1 . LEU A 1 151 ? 225.163 294.667 354.099 1.00 53.57  ? 151 LEU A CD1 1 
ATOM 684  C CD2 . LEU A 1 151 ? 223.202 296.031 353.410 1.00 57.80  ? 151 LEU A CD2 1 
ATOM 685  N N   . ASN A 1 152 ? 220.784 292.180 352.519 1.00 44.55  ? 152 ASN A N   1 
ATOM 686  C CA  . ASN A 1 152 ? 220.131 291.021 351.932 1.00 38.09  ? 152 ASN A CA  1 
ATOM 687  C C   . ASN A 1 152 ? 220.739 289.740 352.487 1.00 48.48  ? 152 ASN A C   1 
ATOM 688  O O   . ASN A 1 152 ? 221.920 289.688 352.835 1.00 50.93  ? 152 ASN A O   1 
ATOM 689  C CB  . ASN A 1 152 ? 220.270 291.052 350.415 1.00 39.70  ? 152 ASN A CB  1 
ATOM 690  C CG  . ASN A 1 152 ? 219.119 290.386 349.717 1.00 41.63  ? 152 ASN A CG  1 
ATOM 691  O OD1 . ASN A 1 152 ? 217.969 290.529 350.121 1.00 44.12  ? 152 ASN A OD1 1 
ATOM 692  N ND2 . ASN A 1 152 ? 219.418 289.642 348.663 1.00 44.18  ? 152 ASN A ND2 1 
ATOM 693  N N   . GLN A 1 153 ? 219.918 288.697 352.572 1.00 39.15  ? 153 GLN A N   1 
ATOM 694  C CA  . GLN A 1 153 ? 220.321 287.436 353.172 1.00 28.16  ? 153 GLN A CA  1 
ATOM 695  C C   . GLN A 1 153 ? 220.359 286.321 352.138 1.00 36.34  ? 153 GLN A C   1 
ATOM 696  O O   . GLN A 1 153 ? 219.562 286.286 351.199 1.00 39.69  ? 153 GLN A O   1 
ATOM 697  C CB  . GLN A 1 153 ? 219.380 287.049 354.312 1.00 40.45  ? 153 GLN A CB  1 
ATOM 698  C CG  . GLN A 1 153 ? 219.631 287.838 355.578 1.00 48.24  ? 153 GLN A CG  1 
ATOM 699  C CD  . GLN A 1 153 ? 218.893 287.282 356.766 1.00 49.97  ? 153 GLN A CD  1 
ATOM 700  O OE1 . GLN A 1 153 ? 217.783 286.769 356.638 1.00 46.37  ? 153 GLN A OE1 1 
ATOM 701  N NE2 . GLN A 1 153 ? 219.509 287.370 357.935 1.00 44.87  ? 153 GLN A NE2 1 
ATOM 702  N N   . VAL A 1 154 ? 221.309 285.412 352.327 1.00 41.54  ? 154 VAL A N   1 
ATOM 703  C CA  . VAL A 1 154 ? 221.480 284.235 351.488 1.00 38.83  ? 154 VAL A CA  1 
ATOM 704  C C   . VAL A 1 154 ? 221.258 283.008 352.356 1.00 39.74  ? 154 VAL A C   1 
ATOM 705  O O   . VAL A 1 154 ? 221.738 282.949 353.491 1.00 37.58  ? 154 VAL A O   1 
ATOM 706  C CB  . VAL A 1 154 ? 222.875 284.201 350.834 1.00 33.52  ? 154 VAL A CB  1 
ATOM 707  C CG1 . VAL A 1 154 ? 223.037 282.953 349.990 1.00 39.60  ? 154 VAL A CG1 1 
ATOM 708  C CG2 . VAL A 1 154 ? 223.090 285.444 349.997 1.00 35.66  ? 154 VAL A CG2 1 
ATOM 709  N N   . TYR A 1 155 ? 220.505 282.047 351.834 1.00 36.72  ? 155 TYR A N   1 
ATOM 710  C CA  . TYR A 1 155 ? 220.161 280.834 352.556 1.00 30.85  ? 155 TYR A CA  1 
ATOM 711  C C   . TYR A 1 155 ? 220.808 279.634 351.889 1.00 29.69  ? 155 TYR A C   1 
ATOM 712  O O   . TYR A 1 155 ? 220.807 279.519 350.658 1.00 35.01  ? 155 TYR A O   1 
ATOM 713  C CB  . TYR A 1 155 ? 218.645 280.634 352.609 1.00 36.39  ? 155 TYR A CB  1 
ATOM 714  C CG  . TYR A 1 155 ? 217.919 281.766 353.274 1.00 34.13  ? 155 TYR A CG  1 
ATOM 715  C CD1 . TYR A 1 155 ? 217.733 281.781 354.641 1.00 37.27  ? 155 TYR A CD1 1 
ATOM 716  C CD2 . TYR A 1 155 ? 217.425 282.823 352.536 1.00 32.77  ? 155 TYR A CD2 1 
ATOM 717  C CE1 . TYR A 1 155 ? 217.078 282.812 355.252 1.00 37.33  ? 155 TYR A CE1 1 
ATOM 718  C CE2 . TYR A 1 155 ? 216.773 283.860 353.139 1.00 39.09  ? 155 TYR A CE2 1 
ATOM 719  C CZ  . TYR A 1 155 ? 216.599 283.851 354.497 1.00 38.25  ? 155 TYR A CZ  1 
ATOM 720  O OH  . TYR A 1 155 ? 215.941 284.888 355.105 1.00 44.81  ? 155 TYR A OH  1 
ATOM 721  N N   . GLN A 1 156 ? 221.365 278.750 352.709 1.00 31.03  ? 156 GLN A N   1 
ATOM 722  C CA  . GLN A 1 156 ? 221.878 277.468 352.256 1.00 32.39  ? 156 GLN A CA  1 
ATOM 723  C C   . GLN A 1 156 ? 220.844 276.397 352.556 1.00 34.49  ? 156 GLN A C   1 
ATOM 724  O O   . GLN A 1 156 ? 220.377 276.279 353.696 1.00 43.42  ? 156 GLN A O   1 
ATOM 725  C CB  . GLN A 1 156 ? 223.201 277.123 352.936 1.00 33.17  ? 156 GLN A CB  1 
ATOM 726  C CG  . GLN A 1 156 ? 223.855 275.887 352.369 1.00 29.52  ? 156 GLN A CG  1 
ATOM 727  C CD  . GLN A 1 156 ? 225.066 275.462 353.154 1.00 35.52  ? 156 GLN A CD  1 
ATOM 728  O OE1 . GLN A 1 156 ? 225.504 276.158 354.068 1.00 41.58  ? 156 GLN A OE1 1 
ATOM 729  N NE2 . GLN A 1 156 ? 225.619 274.311 352.803 1.00 31.27  ? 156 GLN A NE2 1 
ATOM 730  N N   . ILE A 1 157 ? 220.488 275.632 351.530 1.00 26.85  ? 157 ILE A N   1 
ATOM 731  C CA  . ILE A 1 157 ? 219.484 274.583 351.613 1.00 31.16  ? 157 ILE A CA  1 
ATOM 732  C C   . ILE A 1 157 ? 220.161 273.312 351.122 1.00 36.09  ? 157 ILE A C   1 
ATOM 733  O O   . ILE A 1 157 ? 220.345 273.125 349.916 1.00 45.53  ? 157 ILE A O   1 
ATOM 734  C CB  . ILE A 1 157 ? 218.239 274.911 350.784 1.00 24.66  ? 157 ILE A CB  1 
ATOM 735  C CG1 . ILE A 1 157 ? 217.581 276.188 351.310 1.00 27.67  ? 157 ILE A CG1 1 
ATOM 736  C CG2 . ILE A 1 157 ? 217.260 273.753 350.816 1.00 29.91  ? 157 ILE A CG2 1 
ATOM 737  C CD1 . ILE A 1 157 ? 216.633 276.830 350.345 1.00 32.55  ? 157 ILE A CD1 1 
ATOM 738  N N   . MET A 1 158 ? 220.529 272.439 352.050 1.00 22.90  ? 158 MET A N   1 
ATOM 739  C CA  . MET A 1 158 ? 221.329 271.260 351.763 1.00 26.31  ? 158 MET A CA  1 
ATOM 740  C C   . MET A 1 158 ? 220.443 270.025 351.747 1.00 29.48  ? 158 MET A C   1 
ATOM 741  O O   . MET A 1 158 ? 219.626 269.831 352.653 1.00 40.80  ? 158 MET A O   1 
ATOM 742  C CB  . MET A 1 158 ? 222.425 271.105 352.815 1.00 38.17  ? 158 MET A CB  1 
ATOM 743  C CG  . MET A 1 158 ? 223.299 269.885 352.642 1.00 38.88  ? 158 MET A CG  1 
ATOM 744  S SD  . MET A 1 158 ? 224.661 269.875 353.810 1.00 61.27  ? 158 MET A SD  1 
ATOM 745  C CE  . MET A 1 158 ? 223.774 269.970 355.356 1.00 36.35  ? 158 MET A CE  1 
ATOM 746  N N   . TYR A 1 159 ? 220.605 269.193 350.723 1.00 25.59  ? 159 TYR A N   1 
ATOM 747  C CA  . TYR A 1 159 ? 219.896 267.927 350.630 1.00 14.63  ? 159 TYR A CA  1 
ATOM 748  C C   . TYR A 1 159 ? 220.865 266.797 350.946 1.00 37.25  ? 159 TYR A C   1 
ATOM 749  O O   . TYR A 1 159 ? 221.862 266.614 350.242 1.00 47.45  ? 159 TYR A O   1 
ATOM 750  C CB  . TYR A 1 159 ? 219.290 267.736 349.244 1.00 19.73  ? 159 TYR A CB  1 
ATOM 751  C CG  . TYR A 1 159 ? 218.891 266.314 348.959 1.00 24.91  ? 159 TYR A CG  1 
ATOM 752  C CD1 . TYR A 1 159 ? 217.837 265.723 349.631 1.00 30.56  ? 159 TYR A CD1 1 
ATOM 753  C CD2 . TYR A 1 159 ? 219.565 265.563 348.018 1.00 28.66  ? 159 TYR A CD2 1 
ATOM 754  C CE1 . TYR A 1 159 ? 217.471 264.427 349.374 1.00 23.78  ? 159 TYR A CE1 1 
ATOM 755  C CE2 . TYR A 1 159 ? 219.206 264.267 347.755 1.00 33.58  ? 159 TYR A CE2 1 
ATOM 756  C CZ  . TYR A 1 159 ? 218.160 263.703 348.436 1.00 24.94  ? 159 TYR A CZ  1 
ATOM 757  O OH  . TYR A 1 159 ? 217.799 262.407 348.171 1.00 29.04  ? 159 TYR A OH  1 
ATOM 758  N N   . VAL A 1 160 ? 220.566 266.040 351.997 1.00 36.57  ? 160 VAL A N   1 
ATOM 759  C CA  . VAL A 1 160 ? 221.400 264.933 352.448 1.00 23.73  ? 160 VAL A CA  1 
ATOM 760  C C   . VAL A 1 160 ? 220.761 263.641 351.945 1.00 30.69  ? 160 VAL A C   1 
ATOM 761  O O   . VAL A 1 160 ? 219.687 263.265 352.444 1.00 47.10  ? 160 VAL A O   1 
ATOM 762  C CB  . VAL A 1 160 ? 221.527 264.924 353.974 1.00 24.54  ? 160 VAL A CB  1 
ATOM 763  C CG1 . VAL A 1 160 ? 222.495 263.859 354.414 1.00 34.90  ? 160 VAL A CG1 1 
ATOM 764  C CG2 . VAL A 1 160 ? 221.951 266.285 354.479 1.00 35.05  ? 160 VAL A CG2 1 
ATOM 765  N N   . PRO A 1 161 ? 221.360 262.941 350.988 1.00 27.09  ? 161 PRO A N   1 
ATOM 766  C CA  . PRO A 1 161 ? 220.728 261.734 350.453 1.00 25.42  ? 161 PRO A CA  1 
ATOM 767  C C   . PRO A 1 161 ? 220.523 260.691 351.536 1.00 34.42  ? 161 PRO A C   1 
ATOM 768  O O   . PRO A 1 161 ? 220.974 260.868 352.677 1.00 35.70  ? 161 PRO A O   1 
ATOM 769  C CB  . PRO A 1 161 ? 221.719 261.252 349.384 1.00 24.93  ? 161 PRO A CB  1 
ATOM 770  C CG  . PRO A 1 161 ? 222.953 262.015 349.606 1.00 30.73  ? 161 PRO A CG  1 
ATOM 771  C CD  . PRO A 1 161 ? 222.574 263.291 350.237 1.00 30.40  ? 161 PRO A CD  1 
ATOM 772  N N   . PRO A 1 162 ? 219.824 259.597 351.225 1.00 46.57  ? 162 PRO A N   1 
ATOM 773  C CA  . PRO A 1 162 ? 219.535 258.573 352.240 1.00 41.67  ? 162 PRO A CA  1 
ATOM 774  C C   . PRO A 1 162 ? 220.768 257.737 352.553 1.00 37.89  ? 162 PRO A C   1 
ATOM 775  O O   . PRO A 1 162 ? 221.296 257.040 351.686 1.00 41.85  ? 162 PRO A O   1 
ATOM 776  C CB  . PRO A 1 162 ? 218.433 257.733 351.587 1.00 37.65  ? 162 PRO A CB  1 
ATOM 777  C CG  . PRO A 1 162 ? 218.652 257.897 350.139 1.00 35.28  ? 162 PRO A CG  1 
ATOM 778  C CD  . PRO A 1 162 ? 219.182 259.285 349.937 1.00 42.26  ? 162 PRO A CD  1 
ATOM 779  N N   . GLY A 1 163 ? 221.216 257.800 353.800 1.00 38.12  ? 163 GLY A N   1 
ATOM 780  C CA  . GLY A 1 163 ? 222.356 257.033 354.265 1.00 38.24  ? 163 GLY A CA  1 
ATOM 781  C C   . GLY A 1 163 ? 223.501 257.859 354.801 1.00 40.36  ? 163 GLY A C   1 
ATOM 782  O O   . GLY A 1 163 ? 224.458 257.282 355.335 1.00 48.04  ? 163 GLY A O   1 
ATOM 783  N N   . ALA A 1 164 ? 223.445 259.177 354.702 1.00 40.56  ? 164 ALA A N   1 
ATOM 784  C CA  . ALA A 1 164 ? 224.537 260.054 355.081 1.00 44.01  ? 164 ALA A CA  1 
ATOM 785  C C   . ALA A 1 164 ? 224.291 260.670 356.449 1.00 46.47  ? 164 ALA A C   1 
ATOM 786  O O   . ALA A 1 164 ? 223.171 260.641 356.965 1.00 50.93  ? 164 ALA A O   1 
ATOM 787  C CB  . ALA A 1 164 ? 224.705 261.160 354.037 1.00 46.12  ? 164 ALA A CB  1 
ATOM 788  N N   . PRO A 1 165 ? 225.323 261.231 357.075 1.00 46.18  ? 165 PRO A N   1 
ATOM 789  C CA  . PRO A 1 165 ? 225.136 261.856 358.389 1.00 48.09  ? 165 PRO A CA  1 
ATOM 790  C C   . PRO A 1 165 ? 224.272 263.104 358.302 1.00 53.30  ? 165 PRO A C   1 
ATOM 791  O O   . PRO A 1 165 ? 224.184 263.767 357.267 1.00 55.57  ? 165 PRO A O   1 
ATOM 792  C CB  . PRO A 1 165 ? 226.562 262.207 358.829 1.00 44.80  ? 165 PRO A CB  1 
ATOM 793  C CG  . PRO A 1 165 ? 227.463 261.436 357.926 1.00 51.35  ? 165 PRO A CG  1 
ATOM 794  C CD  . PRO A 1 165 ? 226.728 261.276 356.644 1.00 47.80  ? 165 PRO A CD  1 
ATOM 795  N N   . VAL A 1 166 ? 223.634 263.422 359.423 1.00 50.61  ? 166 VAL A N   1 
ATOM 796  C CA  . VAL A 1 166 ? 222.788 264.608 359.531 1.00 46.13  ? 166 VAL A CA  1 
ATOM 797  C C   . VAL A 1 166 ? 223.548 265.682 360.301 1.00 48.96  ? 166 VAL A C   1 
ATOM 798  O O   . VAL A 1 166 ? 224.292 265.355 361.237 1.00 49.06  ? 166 VAL A O   1 
ATOM 799  C CB  . VAL A 1 166 ? 221.451 264.276 360.211 1.00 48.15  ? 166 VAL A CB  1 
ATOM 800  C CG1 . VAL A 1 166 ? 221.675 263.730 361.612 1.00 48.36  ? 166 VAL A CG1 1 
ATOM 801  C CG2 . VAL A 1 166 ? 220.561 265.498 360.256 1.00 50.79  ? 166 VAL A CG2 1 
ATOM 802  N N   . PRO A 1 167 ? 223.411 266.961 359.952 1.00 51.25  ? 167 PRO A N   1 
ATOM 803  C CA  . PRO A 1 167 ? 224.066 268.004 360.744 1.00 48.37  ? 167 PRO A CA  1 
ATOM 804  C C   . PRO A 1 167 ? 223.562 268.024 362.177 1.00 50.84  ? 167 PRO A C   1 
ATOM 805  O O   . PRO A 1 167 ? 222.397 267.740 362.457 1.00 53.48  ? 167 PRO A O   1 
ATOM 806  C CB  . PRO A 1 167 ? 223.698 269.293 360.005 1.00 40.62  ? 167 PRO A CB  1 
ATOM 807  C CG  . PRO A 1 167 ? 223.444 268.866 358.622 1.00 43.18  ? 167 PRO A CG  1 
ATOM 808  C CD  . PRO A 1 167 ? 222.810 267.515 358.729 1.00 47.20  ? 167 PRO A CD  1 
ATOM 809  N N   . GLU A 1 168 ? 224.467 268.363 363.092 1.00 57.71  ? 168 GLU A N   1 
ATOM 810  C CA  . GLU A 1 168 ? 224.145 268.479 364.504 1.00 59.96  ? 168 GLU A CA  1 
ATOM 811  C C   . GLU A 1 168 ? 224.522 269.827 365.096 1.00 63.84  ? 168 GLU A C   1 
ATOM 812  O O   . GLU A 1 168 ? 224.118 270.120 366.226 1.00 62.31  ? 168 GLU A O   1 
ATOM 813  C CB  . GLU A 1 168 ? 224.841 267.364 365.296 1.00 62.11  ? 168 GLU A CB  1 
ATOM 814  C CG  . GLU A 1 168 ? 224.308 265.979 364.974 1.00 64.81  ? 168 GLU A CG  1 
ATOM 815  C CD  . GLU A 1 168 ? 225.320 264.879 365.223 1.00 68.69  ? 168 GLU A CD  1 
ATOM 816  O OE1 . GLU A 1 168 ? 226.341 265.145 365.892 1.00 67.27  ? 168 GLU A OE1 1 
ATOM 817  O OE2 . GLU A 1 168 ? 225.096 263.748 364.744 1.00 66.06  ? 168 GLU A OE2 1 
ATOM 818  N N   . LYS A 1 169 ? 225.280 270.647 364.374 1.00 65.66  ? 169 LYS A N   1 
ATOM 819  C CA  . LYS A 1 169 ? 225.586 272.004 364.794 1.00 64.24  ? 169 LYS A CA  1 
ATOM 820  C C   . LYS A 1 169 ? 225.576 272.895 363.561 1.00 63.43  ? 169 LYS A C   1 
ATOM 821  O O   . LYS A 1 169 ? 225.765 272.429 362.436 1.00 60.03  ? 169 LYS A O   1 
ATOM 822  C CB  . LYS A 1 169 ? 226.934 272.078 365.516 1.00 63.10  ? 169 LYS A CB  1 
ATOM 823  C CG  . LYS A 1 169 ? 227.154 273.369 366.275 1.00 63.08  ? 169 LYS A CG  1 
ATOM 824  C CD  . LYS A 1 169 ? 228.476 273.349 367.019 1.00 66.54  ? 169 LYS A CD  1 
ATOM 825  C CE  . LYS A 1 169 ? 228.673 274.614 367.837 1.00 67.93  ? 169 LYS A CE  1 
ATOM 826  N NZ  . LYS A 1 169 ? 228.673 275.835 366.987 1.00 71.78  ? 169 LYS A NZ  1 
ATOM 827  N N   . TRP A 1 170 ? 225.334 274.188 363.779 1.00 61.62  ? 170 TRP A N   1 
ATOM 828  C CA  . TRP A 1 170 ? 225.166 275.097 362.649 1.00 60.00  ? 170 TRP A CA  1 
ATOM 829  C C   . TRP A 1 170 ? 226.441 275.186 361.822 1.00 62.20  ? 170 TRP A C   1 
ATOM 830  O O   . TRP A 1 170 ? 226.387 275.216 360.587 1.00 60.61  ? 170 TRP A O   1 
ATOM 831  C CB  . TRP A 1 170 ? 224.734 276.477 363.142 1.00 60.40  ? 170 TRP A CB  1 
ATOM 832  C CG  . TRP A 1 170 ? 225.810 277.238 363.823 1.00 61.16  ? 170 TRP A CG  1 
ATOM 833  C CD1 . TRP A 1 170 ? 226.104 277.232 365.152 1.00 62.82  ? 170 TRP A CD1 1 
ATOM 834  C CD2 . TRP A 1 170 ? 226.744 278.128 363.209 1.00 63.29  ? 170 TRP A CD2 1 
ATOM 835  N NE1 . TRP A 1 170 ? 227.167 278.062 365.405 1.00 65.26  ? 170 TRP A NE1 1 
ATOM 836  C CE2 . TRP A 1 170 ? 227.578 278.624 364.226 1.00 63.76  ? 170 TRP A CE2 1 
ATOM 837  C CE3 . TRP A 1 170 ? 226.957 278.551 361.895 1.00 58.48  ? 170 TRP A CE3 1 
ATOM 838  C CZ2 . TRP A 1 170 ? 228.607 279.522 363.972 1.00 59.64  ? 170 TRP A CZ2 1 
ATOM 839  C CZ3 . TRP A 1 170 ? 227.978 279.440 361.645 1.00 63.27  ? 170 TRP A CZ3 1 
ATOM 840  C CH2 . TRP A 1 170 ? 228.791 279.917 362.677 1.00 62.85  ? 170 TRP A CH2 1 
ATOM 841  N N   . ASP A 1 171 ? 227.595 275.229 362.480 1.00 66.17  ? 171 ASP A N   1 
ATOM 842  C CA  . ASP A 1 171 ? 228.893 275.152 361.821 1.00 62.72  ? 171 ASP A CA  1 
ATOM 843  C C   . ASP A 1 171 ? 229.443 273.752 362.041 1.00 62.78  ? 171 ASP A C   1 
ATOM 844  O O   . ASP A 1 171 ? 229.620 273.324 363.186 1.00 66.68  ? 171 ASP A O   1 
ATOM 845  C CB  . ASP A 1 171 ? 229.853 276.205 362.368 1.00 62.45  ? 171 ASP A CB  1 
ATOM 846  C CG  . ASP A 1 171 ? 230.098 276.051 363.855 1.00 66.26  ? 171 ASP A CG  1 
ATOM 847  O OD1 . ASP A 1 171 ? 229.239 275.462 364.542 1.00 69.74  ? 171 ASP A OD1 1 
ATOM 848  O OD2 . ASP A 1 171 ? 231.149 276.519 364.338 1.00 65.35  ? 171 ASP A OD2 1 
ATOM 849  N N   . ASP A 1 172 ? 229.707 273.041 360.953 1.00 56.06  ? 172 ASP A N   1 
ATOM 850  C CA  . ASP A 1 172 ? 230.069 271.638 361.056 1.00 55.82  ? 172 ASP A CA  1 
ATOM 851  C C   . ASP A 1 172 ? 230.466 271.146 359.676 1.00 58.85  ? 172 ASP A C   1 
ATOM 852  O O   . ASP A 1 172 ? 230.048 271.713 358.664 1.00 59.39  ? 172 ASP A O   1 
ATOM 853  C CB  . ASP A 1 172 ? 228.903 270.820 361.620 1.00 51.28  ? 172 ASP A CB  1 
ATOM 854  C CG  . ASP A 1 172 ? 229.124 269.336 361.510 1.00 59.10  ? 172 ASP A CG  1 
ATOM 855  O OD1 . ASP A 1 172 ? 230.223 268.871 361.874 1.00 61.24  ? 172 ASP A OD1 1 
ATOM 856  O OD2 . ASP A 1 172 ? 228.195 268.633 361.064 1.00 59.99  ? 172 ASP A OD2 1 
ATOM 857  N N   . TYR A 1 173 ? 231.272 270.084 359.640 1.00 57.59  ? 173 TYR A N   1 
ATOM 858  C CA  . TYR A 1 173 ? 231.772 269.603 358.360 1.00 57.52  ? 173 TYR A CA  1 
ATOM 859  C C   . TYR A 1 173 ? 230.649 269.127 357.455 1.00 56.82  ? 173 TYR A C   1 
ATOM 860  O O   . TYR A 1 173 ? 230.861 268.978 356.247 1.00 59.45  ? 173 TYR A O   1 
ATOM 861  C CB  . TYR A 1 173 ? 232.780 268.472 358.569 1.00 60.44  ? 173 TYR A CB  1 
ATOM 862  C CG  . TYR A 1 173 ? 232.164 267.129 358.866 1.00 59.20  ? 173 TYR A CG  1 
ATOM 863  C CD1 . TYR A 1 173 ? 231.680 266.832 360.128 1.00 58.38  ? 173 TYR A CD1 1 
ATOM 864  C CD2 . TYR A 1 173 ? 232.080 266.152 357.887 1.00 55.64  ? 173 TYR A CD2 1 
ATOM 865  C CE1 . TYR A 1 173 ? 231.120 265.607 360.403 1.00 54.33  ? 173 TYR A CE1 1 
ATOM 866  C CE2 . TYR A 1 173 ? 231.524 264.924 358.155 1.00 52.12  ? 173 TYR A CE2 1 
ATOM 867  C CZ  . TYR A 1 173 ? 231.049 264.656 359.415 1.00 54.41  ? 173 TYR A CZ  1 
ATOM 868  O OH  . TYR A 1 173 ? 230.492 263.432 359.689 1.00 68.26  ? 173 TYR A OH  1 
ATOM 869  N N   . THR A 1 174 ? 229.460 268.881 358.004 1.00 49.58  ? 174 THR A N   1 
ATOM 870  C CA  . THR A 1 174 ? 228.356 268.434 357.167 1.00 44.29  ? 174 THR A CA  1 
ATOM 871  C C   . THR A 1 174 ? 227.945 269.504 356.167 1.00 47.92  ? 174 THR A C   1 
ATOM 872  O O   . THR A 1 174 ? 227.491 269.169 355.069 1.00 47.68  ? 174 THR A O   1 
ATOM 873  C CB  . THR A 1 174 ? 227.168 268.022 358.029 1.00 48.67  ? 174 THR A CB  1 
ATOM 874  O OG1 . THR A 1 174 ? 226.944 269.006 359.042 1.00 57.00  ? 174 THR A OG1 1 
ATOM 875  C CG2 . THR A 1 174 ? 227.427 266.674 358.678 1.00 43.60  ? 174 THR A CG2 1 
ATOM 876  N N   . TRP A 1 175 ? 228.095 270.785 356.507 1.00 45.00  ? 175 TRP A N   1 
ATOM 877  C CA  . TRP A 1 175 ? 227.924 271.832 355.500 1.00 37.81  ? 175 TRP A CA  1 
ATOM 878  C C   . TRP A 1 175 ? 229.220 272.102 354.764 1.00 41.49  ? 175 TRP A C   1 
ATOM 879  O O   . TRP A 1 175 ? 229.563 273.254 354.494 1.00 46.00  ? 175 TRP A O   1 
ATOM 880  C CB  . TRP A 1 175 ? 227.430 273.118 356.152 1.00 37.92  ? 175 TRP A CB  1 
ATOM 881  C CG  . TRP A 1 175 ? 226.477 272.968 357.280 1.00 44.86  ? 175 TRP A CG  1 
ATOM 882  C CD1 . TRP A 1 175 ? 226.782 272.715 358.577 1.00 41.53  ? 175 TRP A CD1 1 
ATOM 883  C CD2 . TRP A 1 175 ? 225.057 273.113 357.223 1.00 45.29  ? 175 TRP A CD2 1 
ATOM 884  N NE1 . TRP A 1 175 ? 225.640 272.677 359.334 1.00 42.18  ? 175 TRP A NE1 1 
ATOM 885  C CE2 . TRP A 1 175 ? 224.566 272.919 358.521 1.00 42.89  ? 175 TRP A CE2 1 
ATOM 886  C CE3 . TRP A 1 175 ? 224.151 273.378 356.194 1.00 38.08  ? 175 TRP A CE3 1 
ATOM 887  C CZ2 . TRP A 1 175 ? 223.214 272.980 358.818 1.00 40.64  ? 175 TRP A CZ2 1 
ATOM 888  C CZ3 . TRP A 1 175 ? 222.818 273.436 356.491 1.00 38.66  ? 175 TRP A CZ3 1 
ATOM 889  C CH2 . TRP A 1 175 ? 222.360 273.241 357.790 1.00 43.01  ? 175 TRP A CH2 1 
ATOM 890  N N   . GLN A 1 176 ? 229.959 271.051 354.429 1.00 48.93  ? 176 GLN A N   1 
ATOM 891  C CA  . GLN A 1 176 ? 231.144 271.155 353.587 1.00 47.21  ? 176 GLN A CA  1 
ATOM 892  C C   . GLN A 1 176 ? 231.289 270.004 352.616 1.00 47.46  ? 176 GLN A C   1 
ATOM 893  O O   . GLN A 1 176 ? 231.960 270.165 351.593 1.00 52.38  ? 176 GLN A O   1 
ATOM 894  C CB  . GLN A 1 176 ? 232.407 271.227 354.450 1.00 50.85  ? 176 GLN A CB  1 
ATOM 895  C CG  . GLN A 1 176 ? 232.480 272.457 355.333 1.00 52.75  ? 176 GLN A CG  1 
ATOM 896  C CD  . GLN A 1 176 ? 232.592 273.734 354.533 1.00 51.52  ? 176 GLN A CD  1 
ATOM 897  O OE1 . GLN A 1 176 ? 232.900 273.705 353.342 1.00 51.17  ? 176 GLN A OE1 1 
ATOM 898  N NE2 . GLN A 1 176 ? 232.339 274.865 355.181 1.00 47.40  ? 176 GLN A NE2 1 
ATOM 899  N N   . THR A 1 177 ? 230.690 268.854 352.894 1.00 42.56  ? 177 THR A N   1 
ATOM 900  C CA  . THR A 1 177 ? 230.981 267.649 352.144 1.00 37.24  ? 177 THR A CA  1 
ATOM 901  C C   . THR A 1 177 ? 230.589 267.826 350.689 1.00 40.57  ? 177 THR A C   1 
ATOM 902  O O   . THR A 1 177 ? 229.496 268.303 350.380 1.00 48.01  ? 177 THR A O   1 
ATOM 903  C CB  . THR A 1 177 ? 230.233 266.473 352.756 1.00 41.65  ? 177 THR A CB  1 
ATOM 904  O OG1 . THR A 1 177 ? 228.825 266.702 352.645 1.00 55.58  ? 177 THR A OG1 1 
ATOM 905  C CG2 . THR A 1 177 ? 230.591 266.333 354.218 1.00 43.78  ? 177 THR A CG2 1 
ATOM 906  N N   . SER A 1 178 ? 231.489 267.434 349.792 1.00 43.50  ? 178 SER A N   1 
ATOM 907  C CA  . SER A 1 178 ? 231.194 267.500 348.372 1.00 42.93  ? 178 SER A CA  1 
ATOM 908  C C   . SER A 1 178 ? 230.077 266.546 347.978 1.00 46.25  ? 178 SER A C   1 
ATOM 909  O O   . SER A 1 178 ? 229.522 266.677 346.883 1.00 49.84  ? 178 SER A O   1 
ATOM 910  C CB  . SER A 1 178 ? 232.456 267.187 347.575 1.00 34.53  ? 178 SER A CB  1 
ATOM 911  O OG  . SER A 1 178 ? 232.196 267.213 346.190 1.00 38.53  ? 178 SER A OG  1 
ATOM 912  N N   . SER A 1 179 ? 229.737 265.593 348.844 1.00 35.74  ? 179 SER A N   1 
ATOM 913  C CA  . SER A 1 179 ? 228.714 264.610 348.520 1.00 28.80  ? 179 SER A CA  1 
ATOM 914  C C   . SER A 1 179 ? 227.306 265.188 348.631 1.00 36.09  ? 179 SER A C   1 
ATOM 915  O O   . SER A 1 179 ? 226.423 264.818 347.851 1.00 39.09  ? 179 SER A O   1 
ATOM 916  C CB  . SER A 1 179 ? 228.864 263.400 349.436 1.00 42.11  ? 179 SER A CB  1 
ATOM 917  O OG  . SER A 1 179 ? 228.956 263.801 350.789 1.00 38.55  ? 179 SER A OG  1 
ATOM 918  N N   . ASN A 1 180 ? 227.075 266.081 349.586 1.00 38.41  ? 180 ASN A N   1 
ATOM 919  C CA  . ASN A 1 180 ? 225.747 266.649 349.784 1.00 37.94  ? 180 ASN A CA  1 
ATOM 920  C C   . ASN A 1 180 ? 225.539 267.824 348.837 1.00 45.70  ? 180 ASN A C   1 
ATOM 921  O O   . ASN A 1 180 ? 226.277 268.810 348.926 1.00 39.59  ? 180 ASN A O   1 
ATOM 922  C CB  . ASN A 1 180 ? 225.574 267.121 351.217 1.00 30.86  ? 180 ASN A CB  1 
ATOM 923  C CG  . ASN A 1 180 ? 225.729 266.012 352.218 1.00 34.69  ? 180 ASN A CG  1 
ATOM 924  O OD1 . ASN A 1 180 ? 225.720 264.838 351.863 1.00 41.14  ? 180 ASN A OD1 1 
ATOM 925  N ND2 . ASN A 1 180 ? 225.866 266.376 353.483 1.00 34.59  ? 180 ASN A ND2 1 
ATOM 926  N N   . PRO A 1 181 ? 224.563 267.773 347.931 1.00 40.25  ? 181 PRO A N   1 
ATOM 927  C CA  . PRO A 1 181 ? 224.292 268.942 347.088 1.00 29.42  ? 181 PRO A CA  1 
ATOM 928  C C   . PRO A 1 181 ? 223.480 270.002 347.819 1.00 23.78  ? 181 PRO A C   1 
ATOM 929  O O   . PRO A 1 181 ? 222.504 269.708 348.514 1.00 34.46  ? 181 PRO A O   1 
ATOM 930  C CB  . PRO A 1 181 ? 223.514 268.352 345.908 1.00 33.13  ? 181 PRO A CB  1 
ATOM 931  C CG  . PRO A 1 181 ? 222.895 267.131 346.439 1.00 32.20  ? 181 PRO A CG  1 
ATOM 932  C CD  . PRO A 1 181 ? 223.811 266.589 347.481 1.00 23.95  ? 181 PRO A CD  1 
ATOM 933  N N   . SER A 1 182 ? 223.894 271.252 347.643 1.00 29.65  ? 182 SER A N   1 
ATOM 934  C CA  . SER A 1 182 ? 223.282 272.394 348.300 1.00 24.63  ? 182 SER A CA  1 
ATOM 935  C C   . SER A 1 182 ? 222.761 273.376 347.263 1.00 34.92  ? 182 SER A C   1 
ATOM 936  O O   . SER A 1 182 ? 223.153 273.352 346.096 1.00 30.63  ? 182 SER A O   1 
ATOM 937  C CB  . SER A 1 182 ? 224.273 273.115 349.216 1.00 24.36  ? 182 SER A CB  1 
ATOM 938  O OG  . SER A 1 182 ? 224.753 272.254 350.223 1.00 40.09  ? 182 SER A OG  1 
ATOM 939  N N   . ILE A 1 183 ? 221.857 274.238 347.714 1.00 36.89  ? 183 ILE A N   1 
ATOM 940  C CA  . ILE A 1 183 ? 221.362 275.364 346.939 1.00 25.82  ? 183 ILE A CA  1 
ATOM 941  C C   . ILE A 1 183 ? 221.625 276.625 347.741 1.00 28.93  ? 183 ILE A C   1 
ATOM 942  O O   . ILE A 1 183 ? 221.395 276.658 348.955 1.00 33.06  ? 183 ILE A O   1 
ATOM 943  C CB  . ILE A 1 183 ? 219.860 275.239 346.620 1.00 22.92  ? 183 ILE A CB  1 
ATOM 944  C CG1 . ILE A 1 183 ? 219.594 274.027 345.733 1.00 31.76  ? 183 ILE A CG1 1 
ATOM 945  C CG2 . ILE A 1 183 ? 219.365 276.484 345.932 1.00 27.21  ? 183 ILE A CG2 1 
ATOM 946  C CD1 . ILE A 1 183 ? 218.128 273.721 345.582 1.00 37.67  ? 183 ILE A CD1 1 
ATOM 947  N N   . PHE A 1 184 ? 222.131 277.651 347.070 1.00 23.18  ? 184 PHE A N   1 
ATOM 948  C CA  . PHE A 1 184 ? 222.325 278.965 347.666 1.00 19.64  ? 184 PHE A CA  1 
ATOM 949  C C   . PHE A 1 184 ? 221.308 279.914 347.051 1.00 28.35  ? 184 PHE A C   1 
ATOM 950  O O   . PHE A 1 184 ? 221.349 280.174 345.846 1.00 30.51  ? 184 PHE A O   1 
ATOM 951  C CB  . PHE A 1 184 ? 223.752 279.457 347.446 1.00 25.39  ? 184 PHE A CB  1 
ATOM 952  C CG  . PHE A 1 184 ? 224.765 278.730 348.268 1.00 28.18  ? 184 PHE A CG  1 
ATOM 953  C CD1 . PHE A 1 184 ? 225.031 279.129 349.560 1.00 28.50  ? 184 PHE A CD1 1 
ATOM 954  C CD2 . PHE A 1 184 ? 225.442 277.645 347.758 1.00 22.20  ? 184 PHE A CD2 1 
ATOM 955  C CE1 . PHE A 1 184 ? 225.954 278.465 350.321 1.00 20.93  ? 184 PHE A CE1 1 
ATOM 956  C CE2 . PHE A 1 184 ? 226.365 276.976 348.518 1.00 19.07  ? 184 PHE A CE2 1 
ATOM 957  C CZ  . PHE A 1 184 ? 226.622 277.387 349.801 1.00 21.51  ? 184 PHE A CZ  1 
ATOM 958  N N   . TYR A 1 185 ? 220.396 280.416 347.877 1.00 30.44  ? 185 TYR A N   1 
ATOM 959  C CA  . TYR A 1 185 ? 219.255 281.193 347.414 1.00 30.64  ? 185 TYR A CA  1 
ATOM 960  C C   . TYR A 1 185 ? 219.297 282.579 348.039 1.00 38.12  ? 185 TYR A C   1 
ATOM 961  O O   . TYR A 1 185 ? 219.375 282.708 349.262 1.00 39.96  ? 185 TYR A O   1 
ATOM 962  C CB  . TYR A 1 185 ? 217.949 280.472 347.761 1.00 25.57  ? 185 TYR A CB  1 
ATOM 963  C CG  . TYR A 1 185 ? 216.724 281.345 347.760 1.00 33.04  ? 185 TYR A CG  1 
ATOM 964  C CD1 . TYR A 1 185 ? 216.042 281.616 346.587 1.00 33.65  ? 185 TYR A CD1 1 
ATOM 965  C CD2 . TYR A 1 185 ? 216.241 281.887 348.932 1.00 34.62  ? 185 TYR A CD2 1 
ATOM 966  C CE1 . TYR A 1 185 ? 214.927 282.407 346.583 1.00 27.88  ? 185 TYR A CE1 1 
ATOM 967  C CE2 . TYR A 1 185 ? 215.126 282.682 348.936 1.00 32.26  ? 185 TYR A CE2 1 
ATOM 968  C CZ  . TYR A 1 185 ? 214.473 282.938 347.760 1.00 32.27  ? 185 TYR A CZ  1 
ATOM 969  O OH  . TYR A 1 185 ? 213.355 283.731 347.765 1.00 53.15  ? 185 TYR A OH  1 
ATOM 970  N N   . THR A 1 186 ? 219.240 283.609 347.201 1.00 33.71  ? 186 THR A N   1 
ATOM 971  C CA  . THR A 1 186 ? 219.302 284.992 347.655 1.00 29.61  ? 186 THR A CA  1 
ATOM 972  C C   . THR A 1 186 ? 217.892 285.543 347.818 1.00 37.87  ? 186 THR A C   1 
ATOM 973  O O   . THR A 1 186 ? 217.074 285.448 346.900 1.00 48.59  ? 186 THR A O   1 
ATOM 974  C CB  . THR A 1 186 ? 220.109 285.853 346.680 1.00 31.20  ? 186 THR A CB  1 
ATOM 975  O OG1 . THR A 1 186 ? 220.200 287.192 347.180 1.00 30.97  ? 186 THR A OG1 1 
ATOM 976  C CG2 . THR A 1 186 ? 219.471 285.880 345.307 1.00 38.30  ? 186 THR A CG2 1 
ATOM 977  N N   . TYR A 1 187 ? 217.614 286.122 348.982 1.00 35.09  ? 187 TYR A N   1 
ATOM 978  C CA  . TYR A 1 187 ? 216.258 286.543 349.300 1.00 34.34  ? 187 TYR A CA  1 
ATOM 979  C C   . TYR A 1 187 ? 215.749 287.549 348.276 1.00 38.95  ? 187 TYR A C   1 
ATOM 980  O O   . TYR A 1 187 ? 216.480 288.439 347.834 1.00 45.54  ? 187 TYR A O   1 
ATOM 981  C CB  . TYR A 1 187 ? 216.210 287.156 350.697 1.00 33.63  ? 187 TYR A CB  1 
ATOM 982  C CG  . TYR A 1 187 ? 214.816 287.481 351.170 1.00 34.70  ? 187 TYR A CG  1 
ATOM 983  C CD1 . TYR A 1 187 ? 214.033 286.522 351.789 1.00 39.98  ? 187 TYR A CD1 1 
ATOM 984  C CD2 . TYR A 1 187 ? 214.283 288.746 351.001 1.00 36.60  ? 187 TYR A CD2 1 
ATOM 985  C CE1 . TYR A 1 187 ? 212.762 286.813 352.222 1.00 39.92  ? 187 TYR A CE1 1 
ATOM 986  C CE2 . TYR A 1 187 ? 213.012 289.044 351.435 1.00 42.19  ? 187 TYR A CE2 1 
ATOM 987  C CZ  . TYR A 1 187 ? 212.256 288.073 352.044 1.00 39.96  ? 187 TYR A CZ  1 
ATOM 988  O OH  . TYR A 1 187 ? 210.985 288.360 352.474 1.00 35.71  ? 187 TYR A OH  1 
ATOM 989  N N   . GLY A 1 188 ? 214.479 287.407 347.907 1.00 37.82  ? 188 GLY A N   1 
ATOM 990  C CA  . GLY A 1 188 ? 213.840 288.344 347.009 1.00 33.59  ? 188 GLY A CA  1 
ATOM 991  C C   . GLY A 1 188 ? 213.845 287.952 345.553 1.00 30.79  ? 188 GLY A C   1 
ATOM 992  O O   . GLY A 1 188 ? 213.545 288.795 344.704 1.00 40.87  ? 188 GLY A O   1 
ATOM 993  N N   . THR A 1 189 ? 214.179 286.707 345.232 1.00 31.65  ? 189 THR A N   1 
ATOM 994  C CA  . THR A 1 189 ? 214.196 286.254 343.846 1.00 41.07  ? 189 THR A CA  1 
ATOM 995  C C   . THR A 1 189 ? 213.253 285.068 343.680 1.00 36.22  ? 189 THR A C   1 
ATOM 996  O O   . THR A 1 189 ? 212.547 284.700 344.623 1.00 35.48  ? 189 THR A O   1 
ATOM 997  C CB  . THR A 1 189 ? 215.624 285.897 343.418 1.00 42.98  ? 189 THR A CB  1 
ATOM 998  O OG1 . THR A 1 189 ? 215.648 285.579 342.022 1.00 47.61  ? 189 THR A OG1 1 
ATOM 999  C CG2 . THR A 1 189 ? 216.151 284.715 344.208 1.00 43.95  ? 189 THR A CG2 1 
ATOM 1000 N N   . ALA A 1 190 ? 213.230 284.461 342.498 1.00 22.96  ? 190 ALA A N   1 
ATOM 1001 C CA  . ALA A 1 190 ? 212.302 283.375 342.249 1.00 20.89  ? 190 ALA A CA  1 
ATOM 1002 C C   . ALA A 1 190 ? 212.557 282.226 343.224 1.00 42.87  ? 190 ALA A C   1 
ATOM 1003 O O   . ALA A 1 190 ? 213.698 281.987 343.628 1.00 52.02  ? 190 ALA A O   1 
ATOM 1004 C CB  . ALA A 1 190 ? 212.434 282.875 340.816 1.00 21.69  ? 190 ALA A CB  1 
ATOM 1005 N N   . PRO A 1 191 ? 211.513 281.496 343.622 1.00 39.83  ? 191 PRO A N   1 
ATOM 1006 C CA  . PRO A 1 191 ? 211.711 280.383 344.555 1.00 23.60  ? 191 PRO A CA  1 
ATOM 1007 C C   . PRO A 1 191 ? 212.663 279.331 344.005 1.00 31.50  ? 191 PRO A C   1 
ATOM 1008 O O   . PRO A 1 191 ? 212.759 279.115 342.795 1.00 35.98  ? 191 PRO A O   1 
ATOM 1009 C CB  . PRO A 1 191 ? 210.299 279.821 344.730 1.00 22.62  ? 191 PRO A CB  1 
ATOM 1010 C CG  . PRO A 1 191 ? 209.422 280.955 344.460 1.00 26.10  ? 191 PRO A CG  1 
ATOM 1011 C CD  . PRO A 1 191 ? 210.081 281.735 343.376 1.00 28.32  ? 191 PRO A CD  1 
ATOM 1012 N N   . ALA A 1 192 ? 213.384 278.686 344.917 1.00 24.66  ? 192 ALA A N   1 
ATOM 1013 C CA  . ALA A 1 192 ? 214.319 277.632 344.559 1.00 17.18  ? 192 ALA A CA  1 
ATOM 1014 C C   . ALA A 1 192 ? 213.586 276.323 344.297 1.00 24.42  ? 192 ALA A C   1 
ATOM 1015 O O   . ALA A 1 192 ? 212.555 276.034 344.905 1.00 30.90  ? 192 ALA A O   1 
ATOM 1016 C CB  . ALA A 1 192 ? 215.344 277.440 345.671 1.00 21.68  ? 192 ALA A CB  1 
ATOM 1017 N N   . ARG A 1 193 ? 214.142 275.521 343.392 1.00 22.43  ? 193 ARG A N   1 
ATOM 1018 C CA  . ARG A 1 193 ? 213.506 274.287 342.957 1.00 21.56  ? 193 ARG A CA  1 
ATOM 1019 C C   . ARG A 1 193 ? 214.565 273.242 342.638 1.00 28.70  ? 193 ARG A C   1 
ATOM 1020 O O   . ARG A 1 193 ? 215.636 273.575 342.132 1.00 31.89  ? 193 ARG A O   1 
ATOM 1021 C CB  . ARG A 1 193 ? 212.628 274.532 341.727 1.00 17.95  ? 193 ARG A CB  1 
ATOM 1022 C CG  . ARG A 1 193 ? 212.220 273.268 340.992 1.00 30.01  ? 193 ARG A CG  1 
ATOM 1023 C CD  . ARG A 1 193 ? 211.173 273.543 339.939 1.00 35.68  ? 193 ARG A CD  1 
ATOM 1024 N NE  . ARG A 1 193 ? 209.935 274.046 340.520 1.00 34.48  ? 193 ARG A NE  1 
ATOM 1025 C CZ  . ARG A 1 193 ? 208.867 274.397 339.820 1.00 33.93  ? 193 ARG A CZ  1 
ATOM 1026 N NH1 . ARG A 1 193 ? 208.850 274.322 338.501 1.00 37.01  ? 193 ARG A NH1 1 
ATOM 1027 N NH2 . ARG A 1 193 ? 207.791 274.839 340.460 1.00 35.72  ? 193 ARG A NH2 1 
ATOM 1028 N N   . ILE A 1 194 ? 214.255 271.977 342.931 1.00 35.97  ? 194 ILE A N   1 
ATOM 1029 C CA  . ILE A 1 194 ? 215.091 270.840 342.546 1.00 28.67  ? 194 ILE A CA  1 
ATOM 1030 C C   . ILE A 1 194 ? 214.199 269.636 342.281 1.00 29.01  ? 194 ILE A C   1 
ATOM 1031 O O   . ILE A 1 194 ? 213.001 269.649 342.558 1.00 44.13  ? 194 ILE A O   1 
ATOM 1032 C CB  . ILE A 1 194 ? 216.144 270.473 343.615 1.00 34.72  ? 194 ILE A CB  1 
ATOM 1033 C CG1 . ILE A 1 194 ? 215.552 270.614 345.014 1.00 34.27  ? 194 ILE A CG1 1 
ATOM 1034 C CG2 . ILE A 1 194 ? 217.385 271.318 343.440 1.00 34.83  ? 194 ILE A CG2 1 
ATOM 1035 C CD1 . ILE A 1 194 ? 216.387 269.985 346.084 1.00 37.23  ? 194 ILE A CD1 1 
ATOM 1036 N N   . SER A 1 195 ? 214.799 268.580 341.741 1.00 30.25  ? 195 SER A N   1 
ATOM 1037 C CA  . SER A 1 195 ? 214.100 267.329 341.492 1.00 34.19  ? 195 SER A CA  1 
ATOM 1038 C C   . SER A 1 195 ? 214.972 266.174 341.951 1.00 38.76  ? 195 SER A C   1 
ATOM 1039 O O   . SER A 1 195 ? 216.139 266.080 341.562 1.00 46.79  ? 195 SER A O   1 
ATOM 1040 C CB  . SER A 1 195 ? 213.758 267.166 340.011 1.00 37.06  ? 195 SER A CB  1 
ATOM 1041 O OG  . SER A 1 195 ? 214.888 266.752 339.273 1.00 47.00  ? 195 SER A OG  1 
ATOM 1042 N N   . VAL A 1 196 ? 214.398 265.290 342.759 1.00 32.99  ? 196 VAL A N   1 
ATOM 1043 C CA  . VAL A 1 196 ? 215.095 264.110 343.263 1.00 29.51  ? 196 VAL A CA  1 
ATOM 1044 C C   . VAL A 1 196 ? 214.555 262.888 342.530 1.00 33.97  ? 196 VAL A C   1 
ATOM 1045 O O   . VAL A 1 196 ? 213.338 262.786 342.327 1.00 47.26  ? 196 VAL A O   1 
ATOM 1046 C CB  . VAL A 1 196 ? 214.921 263.971 344.782 1.00 35.17  ? 196 VAL A CB  1 
ATOM 1047 C CG1 . VAL A 1 196 ? 215.745 262.812 345.309 1.00 41.48  ? 196 VAL A CG1 1 
ATOM 1048 C CG2 . VAL A 1 196 ? 215.308 265.262 345.479 1.00 33.98  ? 196 VAL A CG2 1 
ATOM 1049 N N   . PRO A 1 197 ? 215.397 261.943 342.113 1.00 31.37  ? 197 PRO A N   1 
ATOM 1050 C CA  . PRO A 1 197 ? 214.881 260.773 341.393 1.00 39.55  ? 197 PRO A CA  1 
ATOM 1051 C C   . PRO A 1 197 ? 214.345 259.711 342.337 1.00 42.92  ? 197 PRO A C   1 
ATOM 1052 O O   . PRO A 1 197 ? 214.207 259.953 343.539 1.00 41.14  ? 197 PRO A O   1 
ATOM 1053 C CB  . PRO A 1 197 ? 216.103 260.281 340.614 1.00 29.44  ? 197 PRO A CB  1 
ATOM 1054 C CG  . PRO A 1 197 ? 217.243 260.660 341.463 1.00 31.81  ? 197 PRO A CG  1 
ATOM 1055 C CD  . PRO A 1 197 ? 216.866 261.921 342.193 1.00 30.54  ? 197 PRO A CD  1 
ATOM 1056 N N   . TYR A 1 198 ? 214.019 258.538 341.802 1.00 35.66  ? 198 TYR A N   1 
ATOM 1057 C CA  . TYR A 1 198 ? 213.596 257.419 342.634 1.00 31.31  ? 198 TYR A CA  1 
ATOM 1058 C C   . TYR A 1 198 ? 214.815 256.817 343.323 1.00 40.94  ? 198 TYR A C   1 
ATOM 1059 O O   . TYR A 1 198 ? 215.634 256.154 342.682 1.00 48.53  ? 198 TYR A O   1 
ATOM 1060 C CB  . TYR A 1 198 ? 212.870 256.378 341.787 1.00 35.40  ? 198 TYR A CB  1 
ATOM 1061 C CG  . TYR A 1 198 ? 212.676 255.063 342.494 1.00 35.36  ? 198 TYR A CG  1 
ATOM 1062 C CD1 . TYR A 1 198 ? 211.860 254.967 343.607 1.00 35.47  ? 198 TYR A CD1 1 
ATOM 1063 C CD2 . TYR A 1 198 ? 213.312 253.919 342.050 1.00 37.95  ? 198 TYR A CD2 1 
ATOM 1064 C CE1 . TYR A 1 198 ? 211.689 253.774 344.259 1.00 36.73  ? 198 TYR A CE1 1 
ATOM 1065 C CE2 . TYR A 1 198 ? 213.147 252.720 342.696 1.00 37.20  ? 198 TYR A CE2 1 
ATOM 1066 C CZ  . TYR A 1 198 ? 212.337 252.653 343.800 1.00 38.29  ? 198 TYR A CZ  1 
ATOM 1067 O OH  . TYR A 1 198 ? 212.169 251.454 344.445 1.00 43.20  ? 198 TYR A OH  1 
ATOM 1068 N N   . VAL A 1 199 ? 214.939 257.045 344.624 1.00 37.42  ? 199 VAL A N   1 
ATOM 1069 C CA  . VAL A 1 199 ? 216.076 256.575 345.406 1.00 35.56  ? 199 VAL A CA  1 
ATOM 1070 C C   . VAL A 1 199 ? 215.568 255.470 346.320 1.00 38.39  ? 199 VAL A C   1 
ATOM 1071 O O   . VAL A 1 199 ? 214.848 255.726 347.290 1.00 46.92  ? 199 VAL A O   1 
ATOM 1072 C CB  . VAL A 1 199 ? 216.741 257.705 346.203 1.00 40.79  ? 199 VAL A CB  1 
ATOM 1073 C CG1 . VAL A 1 199 ? 217.328 258.740 345.261 1.00 46.64  ? 199 VAL A CG1 1 
ATOM 1074 C CG2 . VAL A 1 199 ? 215.763 258.355 347.168 1.00 30.80  ? 199 VAL A CG2 1 
ATOM 1075 N N   . GLY A 1 200 ? 215.942 254.234 346.020 1.00 36.58  ? 200 GLY A N   1 
ATOM 1076 C CA  . GLY A 1 200 ? 215.542 253.117 346.849 1.00 39.98  ? 200 GLY A CA  1 
ATOM 1077 C C   . GLY A 1 200 ? 216.255 251.841 346.469 1.00 43.00  ? 200 GLY A C   1 
ATOM 1078 O O   . GLY A 1 200 ? 216.631 251.653 345.310 1.00 45.34  ? 200 GLY A O   1 
ATOM 1079 N N   . ILE A 1 201 ? 216.435 250.945 347.437 1.00 39.63  ? 201 ILE A N   1 
ATOM 1080 C CA  . ILE A 1 201 ? 217.195 249.729 347.182 1.00 45.70  ? 201 ILE A CA  1 
ATOM 1081 C C   . ILE A 1 201 ? 216.320 248.627 346.599 1.00 48.11  ? 201 ILE A C   1 
ATOM 1082 O O   . ILE A 1 201 ? 216.834 247.752 345.889 1.00 50.26  ? 201 ILE A O   1 
ATOM 1083 C CB  . ILE A 1 201 ? 217.893 249.211 348.454 1.00 42.11  ? 201 ILE A CB  1 
ATOM 1084 C CG1 . ILE A 1 201 ? 218.191 250.348 349.433 1.00 40.50  ? 201 ILE A CG1 1 
ATOM 1085 C CG2 . ILE A 1 201 ? 219.190 248.523 348.089 1.00 40.48  ? 201 ILE A CG2 1 
ATOM 1086 C CD1 . ILE A 1 201 ? 217.079 250.616 350.423 1.00 39.98  ? 201 ILE A CD1 1 
ATOM 1087 N N   . SER A 1 202 ? 215.020 248.646 346.872 1.00 42.91  ? 202 SER A N   1 
ATOM 1088 C CA  . SER A 1 202 ? 214.077 247.730 346.254 1.00 43.16  ? 202 SER A CA  1 
ATOM 1089 C C   . SER A 1 202 ? 213.609 248.305 344.927 1.00 43.21  ? 202 SER A C   1 
ATOM 1090 O O   . SER A 1 202 ? 213.985 249.407 344.531 1.00 53.56  ? 202 SER A O   1 
ATOM 1091 C CB  . SER A 1 202 ? 212.885 247.475 347.175 1.00 43.09  ? 202 SER A CB  1 
ATOM 1092 O OG  . SER A 1 202 ? 213.312 247.031 348.448 1.00 45.03  ? 202 SER A OG  1 
ATOM 1093 N N   . ASN A 1 203 ? 212.769 247.545 344.239 1.00 39.23  ? 203 ASN A N   1 
ATOM 1094 C CA  . ASN A 1 203 ? 212.249 247.975 342.951 1.00 37.40  ? 203 ASN A CA  1 
ATOM 1095 C C   . ASN A 1 203 ? 210.981 248.806 343.077 1.00 40.35  ? 203 ASN A C   1 
ATOM 1096 O O   . ASN A 1 203 ? 210.373 249.131 342.054 1.00 44.27  ? 203 ASN A O   1 
ATOM 1097 C CB  . ASN A 1 203 ? 211.998 246.759 342.065 1.00 43.36  ? 203 ASN A CB  1 
ATOM 1098 C CG  . ASN A 1 203 ? 213.253 245.955 341.827 1.00 46.63  ? 203 ASN A CG  1 
ATOM 1099 O OD1 . ASN A 1 203 ? 213.632 245.122 342.645 1.00 48.64  ? 203 ASN A OD1 1 
ATOM 1100 N ND2 . ASN A 1 203 ? 213.911 246.204 340.705 1.00 44.84  ? 203 ASN A ND2 1 
ATOM 1101 N N   . ALA A 1 204 ? 210.565 249.142 344.297 1.00 31.74  ? 204 ALA A N   1 
ATOM 1102 C CA  . ALA A 1 204 ? 209.424 250.020 344.514 1.00 21.72  ? 204 ALA A CA  1 
ATOM 1103 C C   . ALA A 1 204 ? 209.245 250.305 345.996 1.00 24.01  ? 204 ALA A C   1 
ATOM 1104 O O   . ALA A 1 204 ? 209.614 249.482 346.835 1.00 32.86  ? 204 ALA A O   1 
ATOM 1105 C CB  . ALA A 1 204 ? 208.152 249.397 343.948 1.00 30.26  ? 204 ALA A CB  1 
ATOM 1106 N N   . TYR A 1 205 ? 208.680 251.458 346.333 1.00 25.47  ? 205 TYR A N   1 
ATOM 1107 C CA  . TYR A 1 205 ? 208.332 251.717 347.716 1.00 24.96  ? 205 TYR A CA  1 
ATOM 1108 C C   . TYR A 1 205 ? 207.209 250.780 348.141 1.00 34.85  ? 205 TYR A C   1 
ATOM 1109 O O   . TYR A 1 205 ? 206.440 250.282 347.320 1.00 45.56  ? 205 TYR A O   1 
ATOM 1110 C CB  . TYR A 1 205 ? 207.893 253.166 347.911 1.00 25.03  ? 205 TYR A CB  1 
ATOM 1111 C CG  . TYR A 1 205 ? 208.905 254.195 347.479 1.00 33.03  ? 205 TYR A CG  1 
ATOM 1112 C CD1 . TYR A 1 205 ? 210.253 254.031 347.748 1.00 42.16  ? 205 TYR A CD1 1 
ATOM 1113 C CD2 . TYR A 1 205 ? 208.510 255.335 346.797 1.00 37.33  ? 205 TYR A CD2 1 
ATOM 1114 C CE1 . TYR A 1 205 ? 211.179 254.975 347.352 1.00 30.83  ? 205 TYR A CE1 1 
ATOM 1115 C CE2 . TYR A 1 205 ? 209.426 256.280 346.398 1.00 40.30  ? 205 TYR A CE2 1 
ATOM 1116 C CZ  . TYR A 1 205 ? 210.758 256.097 346.676 1.00 34.65  ? 205 TYR A CZ  1 
ATOM 1117 O OH  . TYR A 1 205 ? 211.669 257.041 346.275 1.00 34.33  ? 205 TYR A OH  1 
ATOM 1118 N N   . SER A 1 206 ? 207.123 250.533 349.443 1.00 41.76  ? 206 SER A N   1 
ATOM 1119 C CA  . SER A 1 206 ? 206.109 249.646 349.999 1.00 45.32  ? 206 SER A CA  1 
ATOM 1120 C C   . SER A 1 206 ? 205.432 250.363 351.156 1.00 47.54  ? 206 SER A C   1 
ATOM 1121 O O   . SER A 1 206 ? 206.056 250.603 352.193 1.00 49.10  ? 206 SER A O   1 
ATOM 1122 C CB  . SER A 1 206 ? 206.721 248.326 350.457 1.00 44.56  ? 206 SER A CB  1 
ATOM 1123 O OG  . SER A 1 206 ? 207.602 248.531 351.544 1.00 51.63  ? 206 SER A OG  1 
ATOM 1124 N N   . HIS A 1 207 ? 204.157 250.702 350.977 1.00 39.43  ? 207 HIS A N   1 
ATOM 1125 C CA  . HIS A 1 207 ? 203.406 251.354 352.039 1.00 39.00  ? 207 HIS A CA  1 
ATOM 1126 C C   . HIS A 1 207 ? 203.018 250.367 353.125 1.00 41.04  ? 207 HIS A C   1 
ATOM 1127 O O   . HIS A 1 207 ? 202.866 250.757 354.288 1.00 42.63  ? 207 HIS A O   1 
ATOM 1128 C CB  . HIS A 1 207 ? 202.162 252.027 351.461 1.00 49.00  ? 207 HIS A CB  1 
ATOM 1129 C CG  . HIS A 1 207 ? 202.397 252.691 350.139 1.00 48.52  ? 207 HIS A CG  1 
ATOM 1130 N ND1 . HIS A 1 207 ? 203.187 253.810 350.000 1.00 43.60  ? 207 HIS A ND1 1 
ATOM 1131 C CD2 . HIS A 1 207 ? 201.960 252.384 348.896 1.00 39.10  ? 207 HIS A CD2 1 
ATOM 1132 C CE1 . HIS A 1 207 ? 203.224 254.164 348.729 1.00 42.86  ? 207 HIS A CE1 1 
ATOM 1133 N NE2 . HIS A 1 207 ? 202.487 253.316 348.038 1.00 31.76  ? 207 HIS A NE2 1 
ATOM 1134 N N   . PHE A 1 208 ? 202.855 249.097 352.764 1.00 47.22  ? 208 PHE A N   1 
ATOM 1135 C CA  . PHE A 1 208 ? 202.538 248.029 353.701 1.00 48.01  ? 208 PHE A CA  1 
ATOM 1136 C C   . PHE A 1 208 ? 203.557 246.917 353.526 1.00 49.72  ? 208 PHE A C   1 
ATOM 1137 O O   . PHE A 1 208 ? 203.831 246.496 352.398 1.00 52.16  ? 208 PHE A O   1 
ATOM 1138 C CB  . PHE A 1 208 ? 201.122 247.502 353.471 1.00 47.78  ? 208 PHE A CB  1 
ATOM 1139 C CG  . PHE A 1 208 ? 200.075 248.570 353.498 1.00 48.12  ? 208 PHE A CG  1 
ATOM 1140 C CD1 . PHE A 1 208 ? 199.492 248.951 354.690 1.00 49.31  ? 208 PHE A CD1 1 
ATOM 1141 C CD2 . PHE A 1 208 ? 199.683 249.203 352.336 1.00 47.85  ? 208 PHE A CD2 1 
ATOM 1142 C CE1 . PHE A 1 208 ? 198.536 249.937 354.720 1.00 46.61  ? 208 PHE A CE1 1 
ATOM 1143 C CE2 . PHE A 1 208 ? 198.726 250.190 352.362 1.00 47.01  ? 208 PHE A CE2 1 
ATOM 1144 C CZ  . PHE A 1 208 ? 198.153 250.557 353.555 1.00 46.14  ? 208 PHE A CZ  1 
ATOM 1145 N N   . TYR A 1 209 ? 204.120 246.449 354.634 1.00 54.39  ? 209 TYR A N   1 
ATOM 1146 C CA  . TYR A 1 209 ? 205.164 245.430 354.600 1.00 58.93  ? 209 TYR A CA  1 
ATOM 1147 C C   . TYR A 1 209 ? 204.886 244.436 355.715 1.00 65.35  ? 209 TYR A C   1 
ATOM 1148 O O   . TYR A 1 209 ? 205.008 244.774 356.895 1.00 67.49  ? 209 TYR A O   1 
ATOM 1149 C CB  . TYR A 1 209 ? 206.547 246.055 354.760 1.00 57.04  ? 209 TYR A CB  1 
ATOM 1150 C CG  . TYR A 1 209 ? 207.687 245.083 354.597 1.00 56.91  ? 209 TYR A CG  1 
ATOM 1151 C CD1 . TYR A 1 209 ? 208.117 244.697 353.340 1.00 58.51  ? 209 TYR A CD1 1 
ATOM 1152 C CD2 . TYR A 1 209 ? 208.339 244.557 355.700 1.00 59.00  ? 209 TYR A CD2 1 
ATOM 1153 C CE1 . TYR A 1 209 ? 209.158 243.813 353.185 1.00 60.73  ? 209 TYR A CE1 1 
ATOM 1154 C CE2 . TYR A 1 209 ? 209.382 243.672 355.554 1.00 61.17  ? 209 TYR A CE2 1 
ATOM 1155 C CZ  . TYR A 1 209 ? 209.787 243.303 354.295 1.00 60.01  ? 209 TYR A CZ  1 
ATOM 1156 O OH  . TYR A 1 209 ? 210.829 242.421 354.146 1.00 64.97  ? 209 TYR A OH  1 
ATOM 1157 N N   . ASP A 1 210 ? 204.506 243.214 355.342 1.00 63.39  ? 210 ASP A N   1 
ATOM 1158 C CA  . ASP A 1 210 ? 204.272 242.144 356.309 1.00 63.04  ? 210 ASP A CA  1 
ATOM 1159 C C   . ASP A 1 210 ? 205.581 241.387 356.502 1.00 67.25  ? 210 ASP A C   1 
ATOM 1160 O O   . ASP A 1 210 ? 205.843 240.355 355.882 1.00 69.30  ? 210 ASP A O   1 
ATOM 1161 C CB  . ASP A 1 210 ? 203.155 241.228 355.831 1.00 66.52  ? 210 ASP A CB  1 
ATOM 1162 C CG  . ASP A 1 210 ? 202.765 240.200 356.866 1.00 66.29  ? 210 ASP A CG  1 
ATOM 1163 O OD1 . ASP A 1 210 ? 203.313 240.247 357.986 1.00 67.15  ? 210 ASP A OD1 1 
ATOM 1164 O OD2 . ASP A 1 210 ? 201.908 239.347 356.561 1.00 64.37  ? 210 ASP A OD2 1 
ATOM 1165 N N   . GLY A 1 211 ? 206.423 241.921 357.377 1.00 75.18  ? 211 GLY A N   1 
ATOM 1166 C CA  . GLY A 1 211 ? 207.716 241.309 357.617 1.00 70.78  ? 211 GLY A CA  1 
ATOM 1167 C C   . GLY A 1 211 ? 208.398 241.941 358.807 1.00 72.69  ? 211 GLY A C   1 
ATOM 1168 O O   . GLY A 1 211 ? 207.982 242.988 359.310 1.00 78.35  ? 211 GLY A O   1 
ATOM 1169 N N   . PHE A 1 212 ? 209.463 241.280 359.249 1.00 72.88  ? 212 PHE A N   1 
ATOM 1170 C CA  . PHE A 1 212 ? 210.263 241.717 360.379 1.00 74.39  ? 212 PHE A CA  1 
ATOM 1171 C C   . PHE A 1 212 ? 211.721 241.812 359.959 1.00 77.35  ? 212 PHE A C   1 
ATOM 1172 O O   . PHE A 1 212 ? 212.156 241.144 359.018 1.00 76.92  ? 212 PHE A O   1 
ATOM 1173 C CB  . PHE A 1 212 ? 210.130 240.752 361.558 1.00 74.94  ? 212 PHE A CB  1 
ATOM 1174 C CG  . PHE A 1 212 ? 208.788 240.787 362.224 1.00 78.02  ? 212 PHE A CG  1 
ATOM 1175 C CD1 . PHE A 1 212 ? 207.671 240.288 361.585 1.00 77.07  ? 212 PHE A CD1 1 
ATOM 1176 C CD2 . PHE A 1 212 ? 208.648 241.306 363.498 1.00 77.96  ? 212 PHE A CD2 1 
ATOM 1177 C CE1 . PHE A 1 212 ? 206.437 240.316 362.196 1.00 74.87  ? 212 PHE A CE1 1 
ATOM 1178 C CE2 . PHE A 1 212 ? 207.418 241.335 364.114 1.00 78.36  ? 212 PHE A CE2 1 
ATOM 1179 C CZ  . PHE A 1 212 ? 206.310 240.840 363.461 1.00 77.03  ? 212 PHE A CZ  1 
ATOM 1180 N N   . SER A 1 213 ? 212.474 242.662 360.658 1.00 84.74  ? 213 SER A N   1 
ATOM 1181 C CA  . SER A 1 213 ? 213.900 242.780 360.377 1.00 90.08  ? 213 SER A CA  1 
ATOM 1182 C C   . SER A 1 213 ? 214.684 241.596 360.937 1.00 90.70  ? 213 SER A C   1 
ATOM 1183 O O   . SER A 1 213 ? 215.626 241.116 360.297 1.00 85.94  ? 213 SER A O   1 
ATOM 1184 C CB  . SER A 1 213 ? 214.437 244.095 360.940 1.00 86.61  ? 213 SER A CB  1 
ATOM 1185 O OG  . SER A 1 213 ? 213.846 245.205 360.291 1.00 86.65  ? 213 SER A OG  1 
ATOM 1186 N N   . LYS A 1 214 ? 214.311 241.115 362.123 1.00 92.91  ? 214 LYS A N   1 
ATOM 1187 C CA  . LYS A 1 214 ? 214.977 239.990 362.766 1.00 89.91  ? 214 LYS A CA  1 
ATOM 1188 C C   . LYS A 1 214 ? 213.937 238.977 363.220 1.00 90.18  ? 214 LYS A C   1 
ATOM 1189 O O   . LYS A 1 214 ? 212.909 239.345 363.796 1.00 91.23  ? 214 LYS A O   1 
ATOM 1190 C CB  . LYS A 1 214 ? 215.819 240.444 363.969 1.00 89.20  ? 214 LYS A CB  1 
ATOM 1191 C CG  . LYS A 1 214 ? 216.942 241.415 363.628 1.00 91.33  ? 214 LYS A CG  1 
ATOM 1192 C CD  . LYS A 1 214 ? 216.466 242.860 363.630 1.00 91.62  ? 214 LYS A CD  1 
ATOM 1193 C CE  . LYS A 1 214 ? 217.559 243.807 363.163 1.00 90.91  ? 214 LYS A CE  1 
ATOM 1194 N NZ  . LYS A 1 214 ? 217.059 245.192 362.953 1.00 90.13  ? 214 LYS A NZ  1 
ATOM 1195 N N   . VAL A 1 215 ? 214.217 237.702 362.968 1.00 85.07  ? 215 VAL A N   1 
ATOM 1196 C CA  . VAL A 1 215 ? 213.305 236.614 363.320 1.00 86.10  ? 215 VAL A CA  1 
ATOM 1197 C C   . VAL A 1 215 ? 213.796 235.959 364.606 1.00 84.56  ? 215 VAL A C   1 
ATOM 1198 O O   . VAL A 1 215 ? 215.012 235.820 364.799 1.00 81.08  ? 215 VAL A O   1 
ATOM 1199 C CB  . VAL A 1 215 ? 213.201 235.594 362.175 1.00 83.73  ? 215 VAL A CB  1 
ATOM 1200 C CG1 . VAL A 1 215 ? 212.402 234.369 362.600 1.00 81.56  ? 215 VAL A CG1 1 
ATOM 1201 C CG2 . VAL A 1 215 ? 212.568 236.241 360.957 1.00 81.62  ? 215 VAL A CG2 1 
ATOM 1202 N N   . PRO A 1 216 ? 212.900 235.544 365.518 1.00 90.70  ? 216 PRO A N   1 
ATOM 1203 C CA  . PRO A 1 216 ? 213.340 234.857 366.738 1.00 88.84  ? 216 PRO A CA  1 
ATOM 1204 C C   . PRO A 1 216 ? 214.209 233.635 366.457 1.00 88.01  ? 216 PRO A C   1 
ATOM 1205 O O   . PRO A 1 216 ? 214.374 232.803 367.349 1.00 86.77  ? 216 PRO A O   1 
ATOM 1206 C CB  . PRO A 1 216 ? 212.022 234.446 367.398 1.00 87.70  ? 216 PRO A CB  1 
ATOM 1207 C CG  . PRO A 1 216 ? 211.049 235.459 366.939 1.00 86.21  ? 216 PRO A CG  1 
ATOM 1208 C CD  . PRO A 1 216 ? 211.449 235.802 365.534 1.00 88.05  ? 216 PRO A CD  1 
ATOM 1209 N N   . SER A 1 227 ? 213.927 244.301 365.473 1.00 87.94  ? 227 SER A N   1 
ATOM 1210 C CA  . SER A 1 227 ? 212.824 243.838 364.638 1.00 91.28  ? 227 SER A CA  1 
ATOM 1211 C C   . SER A 1 227 ? 211.675 244.839 364.659 1.00 91.54  ? 227 SER A C   1 
ATOM 1212 O O   . SER A 1 227 ? 211.181 245.206 365.723 1.00 92.22  ? 227 SER A O   1 
ATOM 1213 C CB  . SER A 1 227 ? 212.337 242.467 365.108 1.00 90.34  ? 227 SER A CB  1 
ATOM 1214 O OG  . SER A 1 227 ? 211.882 242.519 366.448 1.00 88.91  ? 227 SER A OG  1 
ATOM 1215 N N   . LEU A 1 228 ? 211.251 245.275 363.476 1.00 82.95  ? 228 LEU A N   1 
ATOM 1216 C CA  . LEU A 1 228 ? 210.150 246.218 363.336 1.00 85.02  ? 228 LEU A CA  1 
ATOM 1217 C C   . LEU A 1 228 ? 209.143 245.666 362.338 1.00 85.14  ? 228 LEU A C   1 
ATOM 1218 O O   . LEU A 1 228 ? 209.527 245.166 361.276 1.00 82.03  ? 228 LEU A O   1 
ATOM 1219 C CB  . LEU A 1 228 ? 210.653 247.592 362.881 1.00 84.36  ? 228 LEU A CB  1 
ATOM 1220 C CG  . LEU A 1 228 ? 209.594 248.688 362.752 1.00 84.46  ? 228 LEU A CG  1 
ATOM 1221 C CD1 . LEU A 1 228 ? 208.946 248.978 364.095 1.00 82.21  ? 228 LEU A CD1 1 
ATOM 1222 C CD2 . LEU A 1 228 ? 210.207 249.946 362.169 1.00 84.15  ? 228 LEU A CD2 1 
ATOM 1223 N N   . TYR A 1 229 ? 207.860 245.762 362.680 1.00 81.17  ? 229 TYR A N   1 
ATOM 1224 C CA  . TYR A 1 229 ? 206.788 245.268 361.822 1.00 79.60  ? 229 TYR A CA  1 
ATOM 1225 C C   . TYR A 1 229 ? 206.289 246.413 360.949 1.00 79.95  ? 229 TYR A C   1 
ATOM 1226 O O   . TYR A 1 229 ? 205.641 247.342 361.441 1.00 78.37  ? 229 TYR A O   1 
ATOM 1227 C CB  . TYR A 1 229 ? 205.661 244.682 362.667 1.00 76.79  ? 229 TYR A CB  1 
ATOM 1228 C CG  . TYR A 1 229 ? 204.602 243.950 361.873 1.00 77.27  ? 229 TYR A CG  1 
ATOM 1229 C CD1 . TYR A 1 229 ? 204.951 242.996 360.928 1.00 77.27  ? 229 TYR A CD1 1 
ATOM 1230 C CD2 . TYR A 1 229 ? 203.255 244.200 362.081 1.00 74.47  ? 229 TYR A CD2 1 
ATOM 1231 C CE1 . TYR A 1 229 ? 203.991 242.322 360.205 1.00 76.96  ? 229 TYR A CE1 1 
ATOM 1232 C CE2 . TYR A 1 229 ? 202.287 243.529 361.362 1.00 73.57  ? 229 TYR A CE2 1 
ATOM 1233 C CZ  . TYR A 1 229 ? 202.662 242.591 360.427 1.00 77.06  ? 229 TYR A CZ  1 
ATOM 1234 O OH  . TYR A 1 229 ? 201.703 241.918 359.708 1.00 75.60  ? 229 TYR A OH  1 
ATOM 1235 N N   . GLY A 1 230 ? 206.590 246.350 359.656 1.00 71.43  ? 230 GLY A N   1 
ATOM 1236 C CA  . GLY A 1 230 ? 206.204 247.399 358.731 1.00 67.89  ? 230 GLY A CA  1 
ATOM 1237 C C   . GLY A 1 230 ? 206.811 248.743 359.089 1.00 71.14  ? 230 GLY A C   1 
ATOM 1238 O O   . GLY A 1 230 ? 206.404 249.783 358.570 1.00 70.60  ? 230 GLY A O   1 
ATOM 1239 N N   . SER A 1 233 ? 208.794 247.444 356.423 1.00 74.87  ? 233 SER A N   1 
ATOM 1240 C CA  . SER A 1 233 ? 209.925 248.350 356.290 1.00 71.74  ? 233 SER A CA  1 
ATOM 1241 C C   . SER A 1 233 ? 209.446 249.791 356.199 1.00 73.51  ? 233 SER A C   1 
ATOM 1242 O O   . SER A 1 233 ? 208.317 250.057 355.785 1.00 69.51  ? 233 SER A O   1 
ATOM 1243 C CB  . SER A 1 233 ? 210.758 247.997 355.057 1.00 68.90  ? 233 SER A CB  1 
ATOM 1244 O OG  . SER A 1 233 ? 210.015 248.190 353.867 1.00 68.34  ? 233 SER A OG  1 
ATOM 1245 N N   . LEU A 1 234 ? 210.311 250.716 356.599 1.00 65.63  ? 234 LEU A N   1 
ATOM 1246 C CA  . LEU A 1 234 ? 210.069 252.141 356.454 1.00 61.51  ? 234 LEU A CA  1 
ATOM 1247 C C   . LEU A 1 234 ? 210.902 252.671 355.296 1.00 60.85  ? 234 LEU A C   1 
ATOM 1248 O O   . LEU A 1 234 ? 212.020 252.210 355.052 1.00 55.23  ? 234 LEU A O   1 
ATOM 1249 C CB  . LEU A 1 234 ? 210.412 252.894 357.743 1.00 64.84  ? 234 LEU A CB  1 
ATOM 1250 C CG  . LEU A 1 234 ? 209.372 253.901 358.239 1.00 64.99  ? 234 LEU A CG  1 
ATOM 1251 C CD1 . LEU A 1 234 ? 209.016 254.905 357.155 1.00 61.36  ? 234 LEU A CD1 1 
ATOM 1252 C CD2 . LEU A 1 234 ? 208.126 253.187 358.739 1.00 61.01  ? 234 LEU A CD2 1 
ATOM 1253 N N   . ASN A 1 235 ? 210.339 253.635 354.574 1.00 55.36  ? 235 ASN A N   1 
ATOM 1254 C CA  . ASN A 1 235 ? 210.980 254.190 353.393 1.00 53.15  ? 235 ASN A CA  1 
ATOM 1255 C C   . ASN A 1 235 ? 211.885 255.354 353.770 1.00 49.15  ? 235 ASN A C   1 
ATOM 1256 O O   . ASN A 1 235 ? 211.555 256.156 354.647 1.00 51.90  ? 235 ASN A O   1 
ATOM 1257 C CB  . ASN A 1 235 ? 209.928 254.642 352.384 1.00 46.97  ? 235 ASN A CB  1 
ATOM 1258 C CG  . ASN A 1 235 ? 209.054 253.500 351.916 1.00 51.86  ? 235 ASN A CG  1 
ATOM 1259 O OD1 . ASN A 1 235 ? 209.520 252.371 351.762 1.00 50.65  ? 235 ASN A OD1 1 
ATOM 1260 N ND2 . ASN A 1 235 ? 207.776 253.783 351.693 1.00 57.19  ? 235 ASN A ND2 1 
ATOM 1261 N N   . ASP A 1 236 ? 213.037 255.426 353.113 1.00 46.13  ? 236 ASP A N   1 
ATOM 1262 C CA  . ASP A 1 236 ? 214.042 256.449 353.371 1.00 46.60  ? 236 ASP A CA  1 
ATOM 1263 C C   . ASP A 1 236 ? 214.182 257.314 352.128 1.00 46.91  ? 236 ASP A C   1 
ATOM 1264 O O   . ASP A 1 236 ? 214.497 256.806 351.048 1.00 44.76  ? 236 ASP A O   1 
ATOM 1265 C CB  . ASP A 1 236 ? 215.380 255.808 353.737 1.00 41.88  ? 236 ASP A CB  1 
ATOM 1266 C CG  . ASP A 1 236 ? 216.376 256.804 354.282 1.00 48.21  ? 236 ASP A CG  1 
ATOM 1267 O OD1 . ASP A 1 236 ? 215.956 257.902 354.699 1.00 46.88  ? 236 ASP A OD1 1 
ATOM 1268 O OD2 . ASP A 1 236 ? 217.582 256.488 354.292 1.00 46.91  ? 236 ASP A OD2 1 
ATOM 1269 N N   . PHE A 1 237 ? 213.962 258.618 352.284 1.00 32.52  ? 237 PHE A N   1 
ATOM 1270 C CA  . PHE A 1 237 ? 214.000 259.551 351.167 1.00 31.37  ? 237 PHE A CA  1 
ATOM 1271 C C   . PHE A 1 237 ? 215.152 260.540 351.234 1.00 36.26  ? 237 PHE A C   1 
ATOM 1272 O O   . PHE A 1 237 ? 215.632 260.973 350.187 1.00 40.06  ? 237 PHE A O   1 
ATOM 1273 C CB  . PHE A 1 237 ? 212.685 260.335 351.087 1.00 43.08  ? 237 PHE A CB  1 
ATOM 1274 C CG  . PHE A 1 237 ? 211.477 259.471 350.877 1.00 41.68  ? 237 PHE A CG  1 
ATOM 1275 C CD1 . PHE A 1 237 ? 211.197 258.944 349.636 1.00 36.22  ? 237 PHE A CD1 1 
ATOM 1276 C CD2 . PHE A 1 237 ? 210.619 259.198 351.920 1.00 37.14  ? 237 PHE A CD2 1 
ATOM 1277 C CE1 . PHE A 1 237 ? 210.093 258.151 349.442 1.00 32.27  ? 237 PHE A CE1 1 
ATOM 1278 C CE2 . PHE A 1 237 ? 209.514 258.406 351.731 1.00 34.02  ? 237 PHE A CE2 1 
ATOM 1279 C CZ  . PHE A 1 237 ? 209.249 257.884 350.490 1.00 37.84  ? 237 PHE A CZ  1 
ATOM 1280 N N   . GLY A 1 238 ? 215.601 260.911 352.423 1.00 33.88  ? 238 GLY A N   1 
ATOM 1281 C CA  . GLY A 1 238 ? 216.697 261.836 352.578 1.00 23.55  ? 238 GLY A CA  1 
ATOM 1282 C C   . GLY A 1 238 ? 216.447 262.752 353.749 1.00 24.31  ? 238 GLY A C   1 
ATOM 1283 O O   . GLY A 1 238 ? 215.663 262.442 354.639 1.00 37.75  ? 238 GLY A O   1 
ATOM 1284 N N   . ILE A 1 239 ? 217.143 263.887 353.748 1.00 28.76  ? 239 ILE A N   1 
ATOM 1285 C CA  . ILE A 1 239 ? 216.985 264.901 354.782 1.00 30.13  ? 239 ILE A CA  1 
ATOM 1286 C C   . ILE A 1 239 ? 217.200 266.260 354.136 1.00 36.22  ? 239 ILE A C   1 
ATOM 1287 O O   . ILE A 1 239 ? 217.943 266.388 353.162 1.00 48.02  ? 239 ILE A O   1 
ATOM 1288 C CB  . ILE A 1 239 ? 217.961 264.674 355.962 1.00 23.21  ? 239 ILE A CB  1 
ATOM 1289 C CG1 . ILE A 1 239 ? 217.670 263.330 356.627 1.00 31.36  ? 239 ILE A CG1 1 
ATOM 1290 C CG2 . ILE A 1 239 ? 217.858 265.804 356.973 1.00 29.96  ? 239 ILE A CG2 1 
ATOM 1291 C CD1 . ILE A 1 239 ? 218.513 263.041 357.839 1.00 39.83  ? 239 ILE A CD1 1 
ATOM 1292 N N   . LEU A 1 240 ? 216.539 267.280 354.679 1.00 32.53  ? 240 LEU A N   1 
ATOM 1293 C CA  . LEU A 1 240 ? 216.710 268.660 354.242 1.00 28.91  ? 240 LEU A CA  1 
ATOM 1294 C C   . LEU A 1 240 ? 217.185 269.485 355.426 1.00 26.94  ? 240 LEU A C   1 
ATOM 1295 O O   . LEU A 1 240 ? 216.531 269.504 356.474 1.00 35.08  ? 240 LEU A O   1 
ATOM 1296 C CB  . LEU A 1 240 ? 215.407 269.234 353.690 1.00 33.45  ? 240 LEU A CB  1 
ATOM 1297 C CG  . LEU A 1 240 ? 214.889 268.649 352.381 1.00 36.54  ? 240 LEU A CG  1 
ATOM 1298 C CD1 . LEU A 1 240 ? 213.525 269.222 352.077 1.00 32.55  ? 240 LEU A CD1 1 
ATOM 1299 C CD2 . LEU A 1 240 ? 215.849 268.923 351.245 1.00 32.64  ? 240 LEU A CD2 1 
ATOM 1300 N N   . ALA A 1 241 ? 218.318 270.158 355.262 1.00 31.02  ? 241 ALA A N   1 
ATOM 1301 C CA  . ALA A 1 241 ? 218.846 271.055 356.274 1.00 29.33  ? 241 ALA A CA  1 
ATOM 1302 C C   . ALA A 1 241 ? 218.905 272.461 355.698 1.00 39.36  ? 241 ALA A C   1 
ATOM 1303 O O   . ALA A 1 241 ? 219.097 272.643 354.498 1.00 42.33  ? 241 ALA A O   1 
ATOM 1304 C CB  . ALA A 1 241 ? 220.231 270.612 356.739 1.00 33.47  ? 241 ALA A CB  1 
ATOM 1305 N N   . VAL A 1 242 ? 218.709 273.458 356.549 1.00 35.53  ? 242 VAL A N   1 
ATOM 1306 C CA  . VAL A 1 242 ? 218.639 274.842 356.099 1.00 29.82  ? 242 VAL A CA  1 
ATOM 1307 C C   . VAL A 1 242 ? 219.306 275.742 357.125 1.00 39.14  ? 242 VAL A C   1 
ATOM 1308 O O   . VAL A 1 242 ? 219.113 275.576 358.334 1.00 40.78  ? 242 VAL A O   1 
ATOM 1309 C CB  . VAL A 1 242 ? 217.183 275.279 355.853 1.00 32.86  ? 242 VAL A CB  1 
ATOM 1310 C CG1 . VAL A 1 242 ? 217.111 276.766 355.571 1.00 36.95  ? 242 VAL A CG1 1 
ATOM 1311 C CG2 . VAL A 1 242 ? 216.593 274.494 354.700 1.00 36.89  ? 242 VAL A CG2 1 
ATOM 1312 N N   . ARG A 1 243 ? 220.088 276.704 356.634 1.00 44.98  ? 243 ARG A N   1 
ATOM 1313 C CA  . ARG A 1 243 ? 220.675 277.720 357.497 1.00 35.39  ? 243 ARG A CA  1 
ATOM 1314 C C   . ARG A 1 243 ? 220.862 279.007 356.709 1.00 42.28  ? 243 ARG A C   1 
ATOM 1315 O O   . ARG A 1 243 ? 220.632 279.061 355.500 1.00 45.63  ? 243 ARG A O   1 
ATOM 1316 C CB  . ARG A 1 243 ? 222.012 277.271 358.085 1.00 35.84  ? 243 ARG A CB  1 
ATOM 1317 C CG  . ARG A 1 243 ? 223.145 277.238 357.087 1.00 38.41  ? 243 ARG A CG  1 
ATOM 1318 C CD  . ARG A 1 243 ? 224.440 276.858 357.750 1.00 41.38  ? 243 ARG A CD  1 
ATOM 1319 N NE  . ARG A 1 243 ? 225.552 276.891 356.811 1.00 42.35  ? 243 ARG A NE  1 
ATOM 1320 C CZ  . ARG A 1 243 ? 226.820 276.709 357.149 1.00 43.15  ? 243 ARG A CZ  1 
ATOM 1321 N NH1 . ARG A 1 243 ? 227.175 276.480 358.401 1.00 46.52  ? 243 ARG A NH1 1 
ATOM 1322 N NH2 . ARG A 1 243 ? 227.755 276.759 356.206 1.00 42.68  ? 243 ARG A NH2 1 
ATOM 1323 N N   . VAL A 1 244 ? 221.302 280.044 357.415 1.00 47.47  ? 244 VAL A N   1 
ATOM 1324 C CA  . VAL A 1 244 ? 221.551 281.359 356.839 1.00 45.05  ? 244 VAL A CA  1 
ATOM 1325 C C   . VAL A 1 244 ? 223.058 281.572 356.792 1.00 45.58  ? 244 VAL A C   1 
ATOM 1326 O O   . VAL A 1 244 ? 223.727 281.556 357.831 1.00 45.28  ? 244 VAL A O   1 
ATOM 1327 C CB  . VAL A 1 244 ? 220.865 282.467 357.650 1.00 43.33  ? 244 VAL A CB  1 
ATOM 1328 C CG1 . VAL A 1 244 ? 220.902 283.777 356.894 1.00 46.02  ? 244 VAL A CG1 1 
ATOM 1329 C CG2 . VAL A 1 244 ? 219.443 282.076 357.973 1.00 45.98  ? 244 VAL A CG2 1 
ATOM 1330 N N   . VAL A 1 245 ? 223.589 281.785 355.587 1.00 40.46  ? 245 VAL A N   1 
ATOM 1331 C CA  . VAL A 1 245 ? 225.029 281.943 355.424 1.00 31.10  ? 245 VAL A CA  1 
ATOM 1332 C C   . VAL A 1 245 ? 225.524 283.228 356.074 1.00 36.15  ? 245 VAL A C   1 
ATOM 1333 O O   . VAL A 1 245 ? 226.642 283.273 356.597 1.00 43.28  ? 245 VAL A O   1 
ATOM 1334 C CB  . VAL A 1 245 ? 225.399 281.896 353.933 1.00 32.53  ? 245 VAL A CB  1 
ATOM 1335 C CG1 . VAL A 1 245 ? 226.884 282.100 353.753 1.00 36.65  ? 245 VAL A CG1 1 
ATOM 1336 C CG2 . VAL A 1 245 ? 224.965 280.582 353.319 1.00 29.46  ? 245 VAL A CG2 1 
ATOM 1337 N N   . ASN A 1 246 ? 224.726 284.290 356.046 1.00 40.86  ? 246 ASN A N   1 
ATOM 1338 C CA  . ASN A 1 246 ? 225.180 285.573 356.566 1.00 44.64  ? 246 ASN A CA  1 
ATOM 1339 C C   . ASN A 1 246 ? 225.537 285.461 358.041 1.00 51.05  ? 246 ASN A C   1 
ATOM 1340 O O   . ASN A 1 246 ? 224.903 284.723 358.797 1.00 58.24  ? 246 ASN A O   1 
ATOM 1341 C CB  . ASN A 1 246 ? 224.096 286.632 356.377 1.00 42.47  ? 246 ASN A CB  1 
ATOM 1342 C CG  . ASN A 1 246 ? 223.813 286.921 354.925 1.00 44.91  ? 246 ASN A CG  1 
ATOM 1343 O OD1 . ASN A 1 246 ? 223.492 286.024 354.154 1.00 50.97  ? 246 ASN A OD1 1 
ATOM 1344 N ND2 . ASN A 1 246 ? 223.917 288.185 354.545 1.00 45.60  ? 246 ASN A ND2 1 
ATOM 1345 N N   . ASP A 1 247 ? 226.569 286.190 358.447 1.00 54.17  ? 247 ASP A N   1 
ATOM 1346 C CA  . ASP A 1 247 ? 226.920 286.274 359.852 1.00 57.03  ? 247 ASP A CA  1 
ATOM 1347 C C   . ASP A 1 247 ? 225.971 287.227 360.572 1.00 63.43  ? 247 ASP A C   1 
ATOM 1348 O O   . ASP A 1 247 ? 225.283 288.029 359.938 1.00 60.83  ? 247 ASP A O   1 
ATOM 1349 C CB  . ASP A 1 247 ? 228.359 286.741 360.008 1.00 59.70  ? 247 ASP A CB  1 
ATOM 1350 C CG  . ASP A 1 247 ? 228.539 288.181 359.612 1.00 68.63  ? 247 ASP A CG  1 
ATOM 1351 O OD1 . ASP A 1 247 ? 227.754 288.655 358.765 1.00 71.71  ? 247 ASP A OD1 1 
ATOM 1352 O OD2 . ASP A 1 247 ? 229.459 288.838 360.143 1.00 68.81  ? 247 ASP A OD2 1 
ATOM 1353 N N   . PRO A 1 248 ? 225.915 287.161 361.901 1.00 70.23  ? 248 PRO A N   1 
ATOM 1354 C CA  . PRO A 1 248 ? 224.876 287.897 362.629 1.00 69.73  ? 248 PRO A CA  1 
ATOM 1355 C C   . PRO A 1 248 ? 224.913 289.390 362.342 1.00 70.35  ? 248 PRO A C   1 
ATOM 1356 O O   . PRO A 1 248 ? 225.976 290.011 362.301 1.00 69.31  ? 248 PRO A O   1 
ATOM 1357 C CB  . PRO A 1 248 ? 225.199 287.603 364.097 1.00 71.05  ? 248 PRO A CB  1 
ATOM 1358 C CG  . PRO A 1 248 ? 225.980 286.348 364.074 1.00 71.63  ? 248 PRO A CG  1 
ATOM 1359 C CD  . PRO A 1 248 ? 226.776 286.389 362.812 1.00 70.49  ? 248 PRO A CD  1 
ATOM 1360 N N   . ASN A 1 249 ? 223.731 289.961 362.151 1.00 68.72  ? 249 ASN A N   1 
ATOM 1361 C CA  . ASN A 1 249 ? 223.558 291.403 362.086 1.00 67.76  ? 249 ASN A CA  1 
ATOM 1362 C C   . ASN A 1 249 ? 223.341 291.947 363.490 1.00 69.49  ? 249 ASN A C   1 
ATOM 1363 O O   . ASN A 1 249 ? 223.246 291.191 364.458 1.00 71.34  ? 249 ASN A O   1 
ATOM 1364 C CB  . ASN A 1 249 ? 222.369 291.746 361.192 1.00 67.81  ? 249 ASN A CB  1 
ATOM 1365 C CG  . ASN A 1 249 ? 222.762 291.978 359.751 1.00 66.24  ? 249 ASN A CG  1 
ATOM 1366 O OD1 . ASN A 1 249 ? 223.109 293.090 359.363 1.00 65.60  ? 249 ASN A OD1 1 
ATOM 1367 N ND2 . ASN A 1 249 ? 222.695 290.929 358.944 1.00 68.77  ? 249 ASN A ND2 1 
ATOM 1368 N N   . PRO A 1 250 ? 223.271 293.270 363.643 1.00 74.45  ? 250 PRO A N   1 
ATOM 1369 C CA  . PRO A 1 250 ? 222.817 293.841 364.915 1.00 74.26  ? 250 PRO A CA  1 
ATOM 1370 C C   . PRO A 1 250 ? 221.313 293.758 365.126 1.00 77.70  ? 250 PRO A C   1 
ATOM 1371 O O   . PRO A 1 250 ? 220.821 294.251 366.147 1.00 73.93  ? 250 PRO A O   1 
ATOM 1372 C CB  . PRO A 1 250 ? 223.277 295.301 364.815 1.00 72.97  ? 250 PRO A CB  1 
ATOM 1373 C CG  . PRO A 1 250 ? 223.315 295.581 363.365 1.00 73.39  ? 250 PRO A CG  1 
ATOM 1374 C CD  . PRO A 1 250 ? 223.746 294.305 362.711 1.00 75.30  ? 250 PRO A CD  1 
ATOM 1375 N N   . THR A 1 251 ? 220.575 293.160 364.192 1.00 79.19  ? 251 THR A N   1 
ATOM 1376 C CA  . THR A 1 251 ? 219.130 293.018 364.292 1.00 75.65  ? 251 THR A CA  1 
ATOM 1377 C C   . THR A 1 251 ? 218.757 291.559 364.088 1.00 75.74  ? 251 THR A C   1 
ATOM 1378 O O   . THR A 1 251 ? 219.241 290.918 363.150 1.00 77.79  ? 251 THR A O   1 
ATOM 1379 C CB  . THR A 1 251 ? 218.414 293.890 363.256 1.00 75.74  ? 251 THR A CB  1 
ATOM 1380 O OG1 . THR A 1 251 ? 218.838 295.249 363.398 1.00 80.14  ? 251 THR A OG1 1 
ATOM 1381 C CG2 . THR A 1 251 ? 216.905 293.816 363.441 1.00 74.78  ? 251 THR A CG2 1 
ATOM 1382 N N   . LYS A 1 252 ? 217.896 291.041 364.959 1.00 68.86  ? 252 LYS A N   1 
ATOM 1383 C CA  . LYS A 1 252 ? 217.440 289.661 364.860 1.00 65.76  ? 252 LYS A CA  1 
ATOM 1384 C C   . LYS A 1 252 ? 216.330 289.574 363.824 1.00 64.04  ? 252 LYS A C   1 
ATOM 1385 O O   . LYS A 1 252 ? 215.325 290.283 363.932 1.00 71.16  ? 252 LYS A O   1 
ATOM 1386 C CB  . LYS A 1 252 ? 216.948 289.173 366.218 1.00 67.82  ? 252 LYS A CB  1 
ATOM 1387 C CG  . LYS A 1 252 ? 216.342 287.780 366.203 1.00 71.31  ? 252 LYS A CG  1 
ATOM 1388 C CD  . LYS A 1 252 ? 215.813 287.398 367.573 1.00 72.35  ? 252 LYS A CD  1 
ATOM 1389 C CE  . LYS A 1 252 ? 215.107 286.057 367.536 1.00 72.15  ? 252 LYS A CE  1 
ATOM 1390 N NZ  . LYS A 1 252 ? 214.448 285.745 368.831 1.00 72.27  ? 252 LYS A NZ  1 
ATOM 1391 N N   . VAL A 1 253 ? 216.500 288.710 362.824 1.00 52.29  ? 253 VAL A N   1 
ATOM 1392 C CA  . VAL A 1 253 ? 215.511 288.549 361.764 1.00 51.35  ? 253 VAL A CA  1 
ATOM 1393 C C   . VAL A 1 253 ? 215.187 287.071 361.618 1.00 56.00  ? 253 VAL A C   1 
ATOM 1394 O O   . VAL A 1 253 ? 216.094 286.244 361.485 1.00 62.28  ? 253 VAL A O   1 
ATOM 1395 C CB  . VAL A 1 253 ? 216.000 289.130 360.425 1.00 51.11  ? 253 VAL A CB  1 
ATOM 1396 C CG1 . VAL A 1 253 ? 216.372 290.583 360.596 1.00 60.24  ? 253 VAL A CG1 1 
ATOM 1397 C CG2 . VAL A 1 253 ? 217.171 288.340 359.895 1.00 54.41  ? 253 VAL A CG2 1 
ATOM 1398 N N   . THR A 1 254 ? 213.898 286.743 361.621 1.00 52.66  ? 254 THR A N   1 
ATOM 1399 C CA  . THR A 1 254 ? 213.444 285.360 361.609 1.00 46.51  ? 254 THR A CA  1 
ATOM 1400 C C   . THR A 1 254 ? 212.833 285.027 360.258 1.00 44.01  ? 254 THR A C   1 
ATOM 1401 O O   . THR A 1 254 ? 212.117 285.844 359.673 1.00 52.42  ? 254 THR A O   1 
ATOM 1402 C CB  . THR A 1 254 ? 212.422 285.108 362.717 1.00 54.87  ? 254 THR A CB  1 
ATOM 1403 O OG1 . THR A 1 254 ? 212.997 285.437 363.985 1.00 58.66  ? 254 THR A OG1 1 
ATOM 1404 C CG2 . THR A 1 254 ? 211.994 283.650 362.729 1.00 53.60  ? 254 THR A CG2 1 
ATOM 1405 N N   . SER A 1 255 ? 213.110 283.818 359.773 1.00 41.08  ? 255 SER A N   1 
ATOM 1406 C CA  . SER A 1 255 ? 212.712 283.395 358.442 1.00 41.36  ? 255 SER A CA  1 
ATOM 1407 C C   . SER A 1 255 ? 212.031 282.038 358.506 1.00 36.04  ? 255 SER A C   1 
ATOM 1408 O O   . SER A 1 255 ? 212.350 281.200 359.353 1.00 42.40  ? 255 SER A O   1 
ATOM 1409 C CB  . SER A 1 255 ? 213.918 283.311 357.504 1.00 44.64  ? 255 SER A CB  1 
ATOM 1410 O OG  . SER A 1 255 ? 214.763 284.434 357.664 1.00 48.85  ? 255 SER A OG  1 
ATOM 1411 N N   . LYS A 1 256 ? 211.097 281.832 357.586 1.00 29.01  ? 256 LYS A N   1 
ATOM 1412 C CA  . LYS A 1 256 ? 210.378 280.577 357.450 1.00 36.66  ? 256 LYS A CA  1 
ATOM 1413 C C   . LYS A 1 256 ? 210.407 280.128 356.000 1.00 33.99  ? 256 LYS A C   1 
ATOM 1414 O O   . LYS A 1 256 ? 210.184 280.929 355.087 1.00 40.58  ? 256 LYS A O   1 
ATOM 1415 C CB  . LYS A 1 256 ? 208.934 280.711 357.924 1.00 41.66  ? 256 LYS A CB  1 
ATOM 1416 C CG  . LYS A 1 256 ? 208.825 281.030 359.394 1.00 41.60  ? 256 LYS A CG  1 
ATOM 1417 C CD  . LYS A 1 256 ? 207.413 280.885 359.910 1.00 42.58  ? 256 LYS A CD  1 
ATOM 1418 C CE  . LYS A 1 256 ? 207.368 281.131 361.406 1.00 44.43  ? 256 LYS A CE  1 
ATOM 1419 N NZ  . LYS A 1 256 ? 206.003 280.973 361.970 1.00 48.27  ? 256 LYS A NZ  1 
ATOM 1420 N N   . ILE A 1 257 ? 210.678 278.844 355.796 1.00 25.45  ? 257 ILE A N   1 
ATOM 1421 C CA  . ILE A 1 257 ? 210.736 278.240 354.474 1.00 30.34  ? 257 ILE A CA  1 
ATOM 1422 C C   . ILE A 1 257 ? 209.635 277.196 354.394 1.00 37.43  ? 257 ILE A C   1 
ATOM 1423 O O   . ILE A 1 257 ? 209.556 276.306 355.245 1.00 47.46  ? 257 ILE A O   1 
ATOM 1424 C CB  . ILE A 1 257 ? 212.109 277.602 354.193 1.00 25.49  ? 257 ILE A CB  1 
ATOM 1425 C CG1 . ILE A 1 257 ? 213.229 278.634 354.340 1.00 28.37  ? 257 ILE A CG1 1 
ATOM 1426 C CG2 . ILE A 1 257 ? 212.140 277.001 352.802 1.00 26.61  ? 257 ILE A CG2 1 
ATOM 1427 C CD1 . ILE A 1 257 ? 213.734 278.804 355.751 1.00 31.98  ? 257 ILE A CD1 1 
ATOM 1428 N N   . ARG A 1 258 ? 208.790 277.307 353.382 1.00 30.40  ? 258 ARG A N   1 
ATOM 1429 C CA  . ARG A 1 258 ? 207.721 276.351 353.146 1.00 24.10  ? 258 ARG A CA  1 
ATOM 1430 C C   . ARG A 1 258 ? 208.115 275.458 351.984 1.00 31.17  ? 258 ARG A C   1 
ATOM 1431 O O   . ARG A 1 258 ? 208.510 275.956 350.924 1.00 41.20  ? 258 ARG A O   1 
ATOM 1432 C CB  . ARG A 1 258 ? 206.412 277.074 352.847 1.00 24.58  ? 258 ARG A CB  1 
ATOM 1433 C CG  . ARG A 1 258 ? 205.934 277.910 354.001 1.00 28.76  ? 258 ARG A CG  1 
ATOM 1434 C CD  . ARG A 1 258 ? 205.082 279.065 353.550 1.00 38.08  ? 258 ARG A CD  1 
ATOM 1435 N NE  . ARG A 1 258 ? 204.825 279.972 354.659 1.00 35.32  ? 258 ARG A NE  1 
ATOM 1436 C CZ  . ARG A 1 258 ? 203.789 279.887 355.479 1.00 33.58  ? 258 ARG A CZ  1 
ATOM 1437 N NH1 . ARG A 1 258 ? 202.852 278.968 355.321 1.00 29.17  ? 258 ARG A NH1 1 
ATOM 1438 N NH2 . ARG A 1 258 ? 203.688 280.751 356.484 1.00 37.73  ? 258 ARG A NH2 1 
ATOM 1439 N N   . VAL A 1 259 ? 208.013 274.148 352.182 1.00 28.58  ? 259 VAL A N   1 
ATOM 1440 C CA  . VAL A 1 259 ? 208.434 273.178 351.180 1.00 22.23  ? 259 VAL A CA  1 
ATOM 1441 C C   . VAL A 1 259 ? 207.201 272.638 350.475 1.00 19.56  ? 259 VAL A C   1 
ATOM 1442 O O   . VAL A 1 259 ? 206.267 272.160 351.125 1.00 27.14  ? 259 VAL A O   1 
ATOM 1443 C CB  . VAL A 1 259 ? 209.248 272.038 351.813 1.00 27.40  ? 259 VAL A CB  1 
ATOM 1444 C CG1 . VAL A 1 259 ? 209.899 271.197 350.737 1.00 30.50  ? 259 VAL A CG1 1 
ATOM 1445 C CG2 . VAL A 1 259 ? 210.288 272.592 352.765 1.00 32.85  ? 259 VAL A CG2 1 
ATOM 1446 N N   . TYR A 1 260 ? 207.195 272.718 349.149 1.00 32.46  ? 260 TYR A N   1 
ATOM 1447 C CA  . TYR A 1 260 ? 206.105 272.219 348.321 1.00 15.92  ? 260 TYR A CA  1 
ATOM 1448 C C   . TYR A 1 260 ? 206.614 271.043 347.506 1.00 19.18  ? 260 TYR A C   1 
ATOM 1449 O O   . TYR A 1 260 ? 207.542 271.194 346.705 1.00 35.05  ? 260 TYR A O   1 
ATOM 1450 C CB  . TYR A 1 260 ? 205.560 273.319 347.412 1.00 15.43  ? 260 TYR A CB  1 
ATOM 1451 C CG  . TYR A 1 260 ? 204.713 274.317 348.156 1.00 25.98  ? 260 TYR A CG  1 
ATOM 1452 C CD1 . TYR A 1 260 ? 205.291 275.266 348.974 1.00 32.89  ? 260 TYR A CD1 1 
ATOM 1453 C CD2 . TYR A 1 260 ? 203.335 274.298 348.056 1.00 22.00  ? 260 TYR A CD2 1 
ATOM 1454 C CE1 . TYR A 1 260 ? 204.527 276.165 349.668 1.00 27.36  ? 260 TYR A CE1 1 
ATOM 1455 C CE2 . TYR A 1 260 ? 202.565 275.195 348.747 1.00 15.67  ? 260 TYR A CE2 1 
ATOM 1456 C CZ  . TYR A 1 260 ? 203.166 276.126 349.553 1.00 27.67  ? 260 TYR A CZ  1 
ATOM 1457 O OH  . TYR A 1 260 ? 202.401 277.030 350.249 1.00 44.88  ? 260 TYR A OH  1 
ATOM 1458 N N   . LEU A 1 261 ? 205.994 269.886 347.700 1.00 18.59  ? 261 LEU A N   1 
ATOM 1459 C CA  . LEU A 1 261 ? 206.427 268.638 347.097 1.00 25.43  ? 261 LEU A CA  1 
ATOM 1460 C C   . LEU A 1 261 ? 205.459 268.223 346.001 1.00 19.92  ? 261 LEU A C   1 
ATOM 1461 O O   . LEU A 1 261 ? 204.249 268.414 346.125 1.00 31.08  ? 261 LEU A O   1 
ATOM 1462 C CB  . LEU A 1 261 ? 206.526 267.537 348.154 1.00 24.04  ? 261 LEU A CB  1 
ATOM 1463 C CG  . LEU A 1 261 ? 206.618 266.087 347.679 1.00 32.04  ? 261 LEU A CG  1 
ATOM 1464 C CD1 . LEU A 1 261 ? 207.773 265.861 346.727 1.00 33.72  ? 261 LEU A CD1 1 
ATOM 1465 C CD2 . LEU A 1 261 ? 206.746 265.189 348.884 1.00 31.21  ? 261 LEU A CD2 1 
ATOM 1466 N N   . LYS A 1 262 ? 206.000 267.674 344.927 1.00 6.41   ? 262 LYS A N   1 
ATOM 1467 C CA  . LYS A 1 262 ? 205.174 267.209 343.826 1.00 10.08  ? 262 LYS A CA  1 
ATOM 1468 C C   . LYS A 1 262 ? 205.689 265.872 343.310 1.00 25.75  ? 262 LYS A C   1 
ATOM 1469 O O   . LYS A 1 262 ? 206.791 265.814 342.750 1.00 40.05  ? 262 LYS A O   1 
ATOM 1470 C CB  . LYS A 1 262 ? 205.161 268.232 342.698 1.00 23.94  ? 262 LYS A CB  1 
ATOM 1471 C CG  . LYS A 1 262 ? 203.951 268.118 341.812 1.00 31.08  ? 262 LYS A CG  1 
ATOM 1472 C CD  . LYS A 1 262 ? 203.983 269.127 340.700 1.00 33.78  ? 262 LYS A CD  1 
ATOM 1473 C CE  . LYS A 1 262 ? 204.817 268.635 339.544 1.00 39.48  ? 262 LYS A CE  1 
ATOM 1474 N NZ  . LYS A 1 262 ? 204.212 267.443 338.900 1.00 41.72  ? 262 LYS A NZ  1 
ATOM 1475 N N   . PRO A 1 263 ? 204.955 264.778 343.505 1.00 25.46  ? 263 PRO A N   1 
ATOM 1476 C CA  . PRO A 1 263 ? 205.375 263.508 342.910 1.00 20.00  ? 263 PRO A CA  1 
ATOM 1477 C C   . PRO A 1 263 ? 205.267 263.552 341.397 1.00 23.18  ? 263 PRO A C   1 
ATOM 1478 O O   . PRO A 1 263 ? 204.410 264.237 340.840 1.00 32.27  ? 263 PRO A O   1 
ATOM 1479 C CB  . PRO A 1 263 ? 204.409 262.489 343.520 1.00 19.93  ? 263 PRO A CB  1 
ATOM 1480 C CG  . PRO A 1 263 ? 203.269 263.275 343.997 1.00 20.83  ? 263 PRO A CG  1 
ATOM 1481 C CD  . PRO A 1 263 ? 203.791 264.605 344.386 1.00 23.91  ? 263 PRO A CD  1 
ATOM 1482 N N   . LYS A 1 264 ? 206.149 262.812 340.734 1.00 25.45  ? 264 LYS A N   1 
ATOM 1483 C CA  . LYS A 1 264 ? 206.242 262.844 339.287 1.00 22.74  ? 264 LYS A CA  1 
ATOM 1484 C C   . LYS A 1 264 ? 206.527 261.452 338.753 1.00 29.89  ? 264 LYS A C   1 
ATOM 1485 O O   . LYS A 1 264 ? 207.186 260.643 339.407 1.00 37.26  ? 264 LYS A O   1 
ATOM 1486 C CB  . LYS A 1 264 ? 207.334 263.805 338.831 1.00 28.04  ? 264 LYS A CB  1 
ATOM 1487 C CG  . LYS A 1 264 ? 207.137 265.222 339.353 1.00 37.64  ? 264 LYS A CG  1 
ATOM 1488 C CD  . LYS A 1 264 ? 207.871 266.266 338.531 1.00 36.24  ? 264 LYS A CD  1 
ATOM 1489 C CE  . LYS A 1 264 ? 207.561 266.163 337.047 1.00 44.15  ? 264 LYS A CE  1 
ATOM 1490 N NZ  . LYS A 1 264 ? 206.139 265.822 336.774 1.00 47.45  ? 264 LYS A NZ  1 
ATOM 1491 N N   . HIS A 1 265 ? 206.031 261.190 337.546 1.00 31.95  ? 265 HIS A N   1 
ATOM 1492 C CA  . HIS A 1 265 ? 206.231 259.908 336.875 1.00 34.17  ? 265 HIS A CA  1 
ATOM 1493 C C   . HIS A 1 265 ? 205.830 258.745 337.774 1.00 37.92  ? 265 HIS A C   1 
ATOM 1494 O O   . HIS A 1 265 ? 206.528 257.734 337.856 1.00 45.85  ? 265 HIS A O   1 
ATOM 1495 C CB  . HIS A 1 265 ? 207.676 259.756 336.414 1.00 39.06  ? 265 HIS A CB  1 
ATOM 1496 C CG  . HIS A 1 265 ? 208.132 260.844 335.495 1.00 37.02  ? 265 HIS A CG  1 
ATOM 1497 N ND1 . HIS A 1 265 ? 208.861 261.927 335.931 1.00 46.96  ? 265 HIS A ND1 1 
ATOM 1498 C CD2 . HIS A 1 265 ? 207.960 261.016 334.165 1.00 39.02  ? 265 HIS A CD2 1 
ATOM 1499 C CE1 . HIS A 1 265 ? 209.121 262.720 334.908 1.00 49.21  ? 265 HIS A CE1 1 
ATOM 1500 N NE2 . HIS A 1 265 ? 208.585 262.190 333.824 1.00 48.45  ? 265 HIS A NE2 1 
ATOM 1501 N N   . ILE A 1 266 ? 204.694 258.872 338.430 1.00 32.64  ? 266 ILE A N   1 
ATOM 1502 C CA  . ILE A 1 266 ? 204.310 257.946 339.486 1.00 24.93  ? 266 ILE A CA  1 
ATOM 1503 C C   . ILE A 1 266 ? 203.649 256.716 338.887 1.00 23.33  ? 266 ILE A C   1 
ATOM 1504 O O   . ILE A 1 266 ? 202.925 256.798 337.891 1.00 27.84  ? 266 ILE A O   1 
ATOM 1505 C CB  . ILE A 1 266 ? 203.386 258.625 340.511 1.00 25.61  ? 266 ILE A CB  1 
ATOM 1506 C CG1 . ILE A 1 266 ? 202.893 257.590 341.520 1.00 29.82  ? 266 ILE A CG1 1 
ATOM 1507 C CG2 . ILE A 1 266 ? 202.221 259.302 339.829 1.00 31.14  ? 266 ILE A CG2 1 
ATOM 1508 C CD1 . ILE A 1 266 ? 202.442 258.177 342.829 1.00 38.35  ? 266 ILE A CD1 1 
ATOM 1509 N N   . ARG A 1 267 ? 203.922 255.562 339.496 1.00 34.51  ? 267 ARG A N   1 
ATOM 1510 C CA  . ARG A 1 267 ? 203.247 254.310 339.195 1.00 26.88  ? 267 ARG A CA  1 
ATOM 1511 C C   . ARG A 1 267 ? 202.861 253.647 340.507 1.00 32.94  ? 267 ARG A C   1 
ATOM 1512 O O   . ARG A 1 267 ? 203.549 253.801 341.518 1.00 33.38  ? 267 ARG A O   1 
ATOM 1513 C CB  . ARG A 1 267 ? 204.134 253.374 338.376 1.00 20.98  ? 267 ARG A CB  1 
ATOM 1514 C CG  . ARG A 1 267 ? 204.540 253.939 337.037 1.00 28.12  ? 267 ARG A CG  1 
ATOM 1515 C CD  . ARG A 1 267 ? 205.682 253.165 336.422 1.00 35.37  ? 267 ARG A CD  1 
ATOM 1516 N NE  . ARG A 1 267 ? 205.301 251.812 336.038 1.00 36.21  ? 267 ARG A NE  1 
ATOM 1517 C CZ  . ARG A 1 267 ? 206.109 250.950 335.436 1.00 37.10  ? 267 ARG A CZ  1 
ATOM 1518 N NH1 . ARG A 1 267 ? 207.356 251.267 335.133 1.00 33.15  ? 267 ARG A NH1 1 
ATOM 1519 N NH2 . ARG A 1 267 ? 205.654 249.740 335.128 1.00 34.97  ? 267 ARG A NH2 1 
ATOM 1520 N N   . VAL A 1 268 ? 201.747 252.911 340.488 1.00 34.33  ? 268 VAL A N   1 
ATOM 1521 C CA  . VAL A 1 268 ? 201.225 252.243 341.674 1.00 32.40  ? 268 VAL A CA  1 
ATOM 1522 C C   . VAL A 1 268 ? 200.811 250.825 341.304 1.00 39.16  ? 268 VAL A C   1 
ATOM 1523 O O   . VAL A 1 268 ? 200.604 250.502 340.134 1.00 44.06  ? 268 VAL A O   1 
ATOM 1524 C CB  . VAL A 1 268 ? 200.035 253.010 342.288 1.00 37.36  ? 268 VAL A CB  1 
ATOM 1525 C CG1 . VAL A 1 268 ? 200.515 254.284 342.944 1.00 29.40  ? 268 VAL A CG1 1 
ATOM 1526 C CG2 . VAL A 1 268 ? 199.004 253.322 341.227 1.00 38.06  ? 268 VAL A CG2 1 
ATOM 1527 N N   . TRP A 1 269 ? 200.697 249.970 342.323 1.00 36.27  ? 269 TRP A N   1 
ATOM 1528 C CA  . TRP A 1 269 ? 200.300 248.581 342.118 1.00 30.48  ? 269 TRP A CA  1 
ATOM 1529 C C   . TRP A 1 269 ? 199.349 248.122 343.216 1.00 37.07  ? 269 TRP A C   1 
ATOM 1530 O O   . TRP A 1 269 ? 199.322 248.674 344.317 1.00 40.64  ? 269 TRP A O   1 
ATOM 1531 C CB  . TRP A 1 269 ? 201.508 247.633 342.095 1.00 29.11  ? 269 TRP A CB  1 
ATOM 1532 C CG  . TRP A 1 269 ? 202.347 247.710 340.865 1.00 25.54  ? 269 TRP A CG  1 
ATOM 1533 C CD1 . TRP A 1 269 ? 202.196 246.982 339.731 1.00 33.13  ? 269 TRP A CD1 1 
ATOM 1534 C CD2 . TRP A 1 269 ? 203.480 248.552 340.653 1.00 32.96  ? 269 TRP A CD2 1 
ATOM 1535 N NE1 . TRP A 1 269 ? 203.161 247.320 338.821 1.00 35.03  ? 269 TRP A NE1 1 
ATOM 1536 C CE2 . TRP A 1 269 ? 203.962 248.286 339.362 1.00 32.28  ? 269 TRP A CE2 1 
ATOM 1537 C CE3 . TRP A 1 269 ? 204.131 249.511 341.429 1.00 35.37  ? 269 TRP A CE3 1 
ATOM 1538 C CZ2 . TRP A 1 269 ? 205.062 248.941 338.830 1.00 29.42  ? 269 TRP A CZ2 1 
ATOM 1539 C CZ3 . TRP A 1 269 ? 205.219 250.159 340.897 1.00 34.73  ? 269 TRP A CZ3 1 
ATOM 1540 C CH2 . TRP A 1 269 ? 205.675 249.872 339.611 1.00 32.10  ? 269 TRP A CH2 1 
ATOM 1541 N N   . CYS A 1 270 ? 198.566 247.082 342.892 1.00 35.77  ? 270 CYS A N   1 
ATOM 1542 C CA  . CYS A 1 270 ? 197.803 246.289 343.857 1.00 32.50  ? 270 CYS A CA  1 
ATOM 1543 C C   . CYS A 1 270 ? 196.905 247.133 344.758 1.00 33.75  ? 270 CYS A C   1 
ATOM 1544 O O   . CYS A 1 270 ? 197.228 247.345 345.932 1.00 31.91  ? 270 CYS A O   1 
ATOM 1545 C CB  . CYS A 1 270 ? 198.757 245.455 344.711 1.00 37.61  ? 270 CYS A CB  1 
ATOM 1546 S SG  . CYS A 1 270 ? 199.595 244.133 343.804 1.00 40.16  ? 270 CYS A SG  1 
ATOM 1547 N N   . PRO A 1 271 ? 195.767 247.608 344.255 1.00 32.41  ? 271 PRO A N   1 
ATOM 1548 C CA  . PRO A 1 271 ? 194.928 248.523 345.036 1.00 24.54  ? 271 PRO A CA  1 
ATOM 1549 C C   . PRO A 1 271 ? 194.393 247.889 346.309 1.00 20.55  ? 271 PRO A C   1 
ATOM 1550 O O   . PRO A 1 271 ? 194.243 246.673 346.418 1.00 43.77  ? 271 PRO A O   1 
ATOM 1551 C CB  . PRO A 1 271 ? 193.790 248.862 344.071 1.00 29.10  ? 271 PRO A CB  1 
ATOM 1552 C CG  . PRO A 1 271 ? 193.735 247.720 343.144 1.00 28.08  ? 271 PRO A CG  1 
ATOM 1553 C CD  . PRO A 1 271 ? 195.137 247.249 342.975 1.00 33.30  ? 271 PRO A CD  1 
ATOM 1554 N N   . ARG A 1 272 ? 194.104 248.739 347.283 1.00 22.63  ? 272 ARG A N   1 
ATOM 1555 C CA  . ARG A 1 272 ? 193.557 248.344 348.570 1.00 27.71  ? 272 ARG A CA  1 
ATOM 1556 C C   . ARG A 1 272 ? 192.375 249.230 348.921 1.00 39.56  ? 272 ARG A C   1 
ATOM 1557 O O   . ARG A 1 272 ? 192.211 250.315 348.356 1.00 48.53  ? 272 ARG A O   1 
ATOM 1558 C CB  . ARG A 1 272 ? 194.602 248.445 349.688 1.00 26.01  ? 272 ARG A CB  1 
ATOM 1559 C CG  . ARG A 1 272 ? 195.913 247.776 349.386 1.00 33.74  ? 272 ARG A CG  1 
ATOM 1560 C CD  . ARG A 1 272 ? 196.905 248.025 350.497 1.00 44.82  ? 272 ARG A CD  1 
ATOM 1561 N NE  . ARG A 1 272 ? 196.624 247.255 351.703 1.00 47.67  ? 272 ARG A NE  1 
ATOM 1562 C CZ  . ARG A 1 272 ? 197.060 246.023 351.926 1.00 42.17  ? 272 ARG A CZ  1 
ATOM 1563 N NH1 . ARG A 1 272 ? 197.741 245.353 351.012 1.00 37.26  ? 272 ARG A NH1 1 
ATOM 1564 N NH2 . ARG A 1 272 ? 196.805 245.448 353.097 1.00 41.66  ? 272 ARG A NH2 1 
ATOM 1565 N N   . PRO A 1 273 ? 191.524 248.792 349.846 1.00 44.16  ? 273 PRO A N   1 
ATOM 1566 C CA  . PRO A 1 273 ? 190.458 249.659 350.320 1.00 42.83  ? 273 PRO A CA  1 
ATOM 1567 C C   . PRO A 1 273 ? 191.036 250.852 351.080 1.00 49.19  ? 273 PRO A C   1 
ATOM 1568 O O   . PRO A 1 273 ? 192.071 250.726 351.752 1.00 44.43  ? 273 PRO A O   1 
ATOM 1569 C CB  . PRO A 1 273 ? 189.644 248.750 351.247 1.00 44.39  ? 273 PRO A CB  1 
ATOM 1570 C CG  . PRO A 1 273 ? 190.030 247.376 350.885 1.00 46.83  ? 273 PRO A CG  1 
ATOM 1571 C CD  . PRO A 1 273 ? 191.441 247.454 350.450 1.00 44.12  ? 273 PRO A CD  1 
ATOM 1572 N N   . PRO A 1 274 ? 190.382 252.004 351.000 1.00 51.34  ? 274 PRO A N   1 
ATOM 1573 C CA  . PRO A 1 274 ? 190.867 253.169 351.746 1.00 48.92  ? 274 PRO A CA  1 
ATOM 1574 C C   . PRO A 1 274 ? 190.389 253.170 353.188 1.00 48.48  ? 274 PRO A C   1 
ATOM 1575 O O   . PRO A 1 274 ? 189.356 252.595 353.530 1.00 52.90  ? 274 PRO A O   1 
ATOM 1576 C CB  . PRO A 1 274 ? 190.267 254.343 350.969 1.00 45.75  ? 274 PRO A CB  1 
ATOM 1577 C CG  . PRO A 1 274 ? 189.004 253.803 350.441 1.00 42.13  ? 274 PRO A CG  1 
ATOM 1578 C CD  . PRO A 1 274 ? 189.253 252.357 350.126 1.00 41.60  ? 274 PRO A CD  1 
ATOM 1579 N N   . ARG A 1 275 ? 191.159 253.841 354.036 1.00 47.26  ? 275 ARG A N   1 
ATOM 1580 C CA  . ARG A 1 275 ? 190.814 253.972 355.441 1.00 52.30  ? 275 ARG A CA  1 
ATOM 1581 C C   . ARG A 1 275 ? 189.980 255.225 355.679 1.00 55.93  ? 275 ARG A C   1 
ATOM 1582 O O   . ARG A 1 275 ? 189.957 256.152 354.869 1.00 62.25  ? 275 ARG A O   1 
ATOM 1583 C CB  . ARG A 1 275 ? 192.071 254.022 356.308 1.00 56.83  ? 275 ARG A CB  1 
ATOM 1584 C CG  . ARG A 1 275 ? 192.668 252.663 356.610 1.00 60.90  ? 275 ARG A CG  1 
ATOM 1585 C CD  . ARG A 1 275 ? 193.819 252.763 357.590 1.00 59.85  ? 275 ARG A CD  1 
ATOM 1586 N NE  . ARG A 1 275 ? 193.437 253.453 358.817 1.00 64.07  ? 275 ARG A NE  1 
ATOM 1587 C CZ  . ARG A 1 275 ? 194.227 253.600 359.871 1.00 63.70  ? 275 ARG A CZ  1 
ATOM 1588 N NH1 . ARG A 1 275 ? 195.449 253.095 359.895 1.00 59.40  ? 275 ARG A NH1 1 
ATOM 1589 N NH2 . ARG A 1 275 ? 193.780 254.271 360.927 1.00 66.78  ? 275 ARG A NH2 1 
ATOM 1590 N N   . ALA A 1 276 ? 189.292 255.242 356.816 1.00 63.56  ? 276 ALA A N   1 
ATOM 1591 C CA  . ALA A 1 276 ? 188.482 256.385 357.203 1.00 64.33  ? 276 ALA A CA  1 
ATOM 1592 C C   . ALA A 1 276 ? 189.358 257.479 357.807 1.00 68.15  ? 276 ALA A C   1 
ATOM 1593 O O   . ALA A 1 276 ? 190.556 257.299 358.040 1.00 73.04  ? 276 ALA A O   1 
ATOM 1594 C CB  . ALA A 1 276 ? 187.404 255.960 358.196 1.00 63.18  ? 276 ALA A CB  1 
ATOM 1595 N N   . VAL A 1 277 ? 188.746 258.632 358.063 1.00 67.35  ? 277 VAL A N   1 
ATOM 1596 C CA  . VAL A 1 277 ? 189.466 259.772 358.660 1.00 69.64  ? 277 VAL A CA  1 
ATOM 1597 C C   . VAL A 1 277 ? 189.329 259.616 360.169 1.00 69.89  ? 277 VAL A C   1 
ATOM 1598 O O   . VAL A 1 277 ? 188.441 260.174 360.819 1.00 66.10  ? 277 VAL A O   1 
ATOM 1599 C CB  . VAL A 1 277 ? 188.945 261.118 358.153 1.00 67.52  ? 277 VAL A CB  1 
ATOM 1600 C CG1 . VAL A 1 277 ? 189.754 262.253 358.752 1.00 64.90  ? 277 VAL A CG1 1 
ATOM 1601 C CG2 . VAL A 1 277 ? 188.997 261.165 356.640 1.00 65.57  ? 277 VAL A CG2 1 
ATOM 1602 N N   . ALA A 1 278 ? 190.241 258.834 360.745 1.00 77.77  ? 278 ALA A N   1 
ATOM 1603 C CA  . ALA A 1 278 ? 190.314 258.642 362.187 1.00 74.98  ? 278 ALA A CA  1 
ATOM 1604 C C   . ALA A 1 278 ? 191.675 259.100 362.688 1.00 74.59  ? 278 ALA A C   1 
ATOM 1605 O O   . ALA A 1 278 ? 192.348 258.371 363.424 1.00 73.07  ? 278 ALA A O   1 
ATOM 1606 C CB  . ALA A 1 278 ? 190.073 257.177 362.547 1.00 76.27  ? 278 ALA A CB  1 
ATOM 1607 N N   . TYR A 1 279 ? 192.104 260.287 362.252 1.00 82.98  ? 279 TYR A N   1 
ATOM 1608 C CA  . TYR A 1 279 ? 193.461 260.781 362.477 1.00 82.70  ? 279 TYR A CA  1 
ATOM 1609 C C   . TYR A 1 279 ? 194.484 259.882 361.797 1.00 83.86  ? 279 TYR A C   1 
ATOM 1610 O O   . TYR A 1 279 ? 195.691 260.126 361.895 1.00 81.97  ? 279 TYR A O   1 
ATOM 1611 C CB  . TYR A 1 279 ? 193.787 260.883 363.971 1.00 81.53  ? 279 TYR A CB  1 
ATOM 1612 C CG  . TYR A 1 279 ? 193.317 262.150 364.647 1.00 82.22  ? 279 TYR A CG  1 
ATOM 1613 C CD1 . TYR A 1 279 ? 192.377 262.979 364.054 1.00 82.63  ? 279 TYR A CD1 1 
ATOM 1614 C CD2 . TYR A 1 279 ? 193.828 262.520 365.883 1.00 81.36  ? 279 TYR A CD2 1 
ATOM 1615 C CE1 . TYR A 1 279 ? 191.954 264.137 364.676 1.00 84.42  ? 279 TYR A CE1 1 
ATOM 1616 C CE2 . TYR A 1 279 ? 193.413 263.673 366.512 1.00 82.88  ? 279 TYR A CE2 1 
ATOM 1617 C CZ  . TYR A 1 279 ? 192.477 264.480 365.905 1.00 86.26  ? 279 TYR A CZ  1 
ATOM 1618 O OH  . TYR A 1 279 ? 192.066 265.630 366.538 1.00 86.22  ? 279 TYR A OH  1 
ATOM 1619 N N   . TYR A 1 280 ? 194.015 258.856 361.088 1.00 69.59  ? 280 TYR A N   1 
ATOM 1620 C CA  . TYR A 1 280 ? 194.899 257.854 360.514 1.00 67.26  ? 280 TYR A CA  1 
ATOM 1621 C C   . TYR A 1 280 ? 195.707 257.199 361.629 1.00 69.59  ? 280 TYR A C   1 
ATOM 1622 O O   . TYR A 1 280 ? 195.190 257.011 362.733 1.00 70.89  ? 280 TYR A O   1 
ATOM 1623 C CB  . TYR A 1 280 ? 195.776 258.502 359.438 1.00 64.45  ? 280 TYR A CB  1 
ATOM 1624 C CG  . TYR A 1 280 ? 195.587 257.859 358.097 1.00 61.55  ? 280 TYR A CG  1 
ATOM 1625 C CD1 . TYR A 1 280 ? 194.593 258.288 357.243 1.00 57.26  ? 280 TYR A CD1 1 
ATOM 1626 C CD2 . TYR A 1 280 ? 196.382 256.801 357.697 1.00 66.27  ? 280 TYR A CD2 1 
ATOM 1627 C CE1 . TYR A 1 280 ? 194.405 257.695 356.028 1.00 61.76  ? 280 TYR A CE1 1 
ATOM 1628 C CE2 . TYR A 1 280 ? 196.201 256.202 356.480 1.00 63.14  ? 280 TYR A CE2 1 
ATOM 1629 C CZ  . TYR A 1 280 ? 195.211 256.654 355.648 1.00 62.70  ? 280 TYR A CZ  1 
ATOM 1630 O OH  . TYR A 1 280 ? 195.020 256.056 354.426 1.00 67.42  ? 280 TYR A OH  1 
ATOM 1631 N N   . GLY A 1 281 ? 196.964 256.842 361.367 1.00 82.12  ? 281 GLY A N   1 
ATOM 1632 C CA  . GLY A 1 281 ? 197.820 256.283 362.385 1.00 81.71  ? 281 GLY A CA  1 
ATOM 1633 C C   . GLY A 1 281 ? 199.267 256.224 361.937 1.00 83.15  ? 281 GLY A C   1 
ATOM 1634 O O   . GLY A 1 281 ? 199.586 256.438 360.765 1.00 85.62  ? 281 GLY A O   1 
ATOM 1635 N N   . PRO A 1 282 ? 200.177 255.932 362.871 1.00 83.27  ? 282 PRO A N   1 
ATOM 1636 C CA  . PRO A 1 282 ? 201.596 255.858 362.490 1.00 81.19  ? 282 PRO A CA  1 
ATOM 1637 C C   . PRO A 1 282 ? 201.916 254.655 361.620 1.00 83.19  ? 282 PRO A C   1 
ATOM 1638 O O   . PRO A 1 282 ? 202.732 254.764 360.696 1.00 78.31  ? 282 PRO A O   1 
ATOM 1639 C CB  . PRO A 1 282 ? 202.311 255.799 363.845 1.00 80.72  ? 282 PRO A CB  1 
ATOM 1640 C CG  . PRO A 1 282 ? 201.315 255.164 364.756 1.00 82.83  ? 282 PRO A CG  1 
ATOM 1641 C CD  . PRO A 1 282 ? 199.963 255.628 364.295 1.00 83.87  ? 282 PRO A CD  1 
ATOM 1642 N N   . GLY A 1 283 ? 201.300 253.506 361.896 1.00 81.68  ? 283 GLY A N   1 
ATOM 1643 C CA  . GLY A 1 283 ? 201.433 252.332 361.054 1.00 78.58  ? 283 GLY A CA  1 
ATOM 1644 C C   . GLY A 1 283 ? 200.090 251.904 360.497 1.00 82.25  ? 283 GLY A C   1 
ATOM 1645 O O   . GLY A 1 283 ? 199.260 252.752 360.159 1.00 83.37  ? 283 GLY A O   1 
ATOM 1646 N N   . VAL A 1 284 ? 199.860 250.598 360.391 1.00 80.98  ? 284 VAL A N   1 
ATOM 1647 C CA  . VAL A 1 284 ? 198.552 250.089 359.995 1.00 81.15  ? 284 VAL A CA  1 
ATOM 1648 C C   . VAL A 1 284 ? 197.692 249.923 361.241 1.00 82.97  ? 284 VAL A C   1 
ATOM 1649 O O   . VAL A 1 284 ? 196.568 249.415 361.168 1.00 81.29  ? 284 VAL A O   1 
ATOM 1650 C CB  . VAL A 1 284 ? 198.669 248.762 359.224 1.00 80.64  ? 284 VAL A CB  1 
ATOM 1651 C CG1 . VAL A 1 284 ? 199.678 248.892 358.094 1.00 78.80  ? 284 VAL A CG1 1 
ATOM 1652 C CG2 . VAL A 1 284 ? 199.045 247.630 360.164 1.00 79.58  ? 284 VAL A CG2 1 
ATOM 1653 N N   . ASP A 1 285 ? 198.215 250.341 362.391 1.00 89.12  ? 285 ASP A N   1 
ATOM 1654 C CA  . ASP A 1 285 ? 197.466 250.252 363.631 1.00 87.42  ? 285 ASP A CA  1 
ATOM 1655 C C   . ASP A 1 285 ? 196.283 251.215 363.615 1.00 83.07  ? 285 ASP A C   1 
ATOM 1656 O O   . ASP A 1 285 ? 196.301 252.258 362.958 1.00 83.94  ? 285 ASP A O   1 
ATOM 1657 C CB  . ASP A 1 285 ? 198.370 250.555 364.826 1.00 88.61  ? 285 ASP A CB  1 
ATOM 1658 C CG  . ASP A 1 285 ? 199.400 249.469 365.068 1.00 88.31  ? 285 ASP A CG  1 
ATOM 1659 O OD1 . ASP A 1 285 ? 199.461 248.516 364.264 1.00 85.67  ? 285 ASP A OD1 1 
ATOM 1660 O OD2 . ASP A 1 285 ? 200.145 249.563 366.065 1.00 87.80  ? 285 ASP A OD2 1 
ATOM 1661 N N   . TYR A 1 286 ? 195.239 250.844 364.349 1.00 76.84  ? 286 TYR A N   1 
ATOM 1662 C CA  . TYR A 1 286 ? 194.056 251.683 364.481 1.00 80.09  ? 286 TYR A CA  1 
ATOM 1663 C C   . TYR A 1 286 ? 193.415 251.492 365.851 1.00 78.11  ? 286 TYR A C   1 
ATOM 1664 O O   . TYR A 1 286 ? 192.253 251.841 366.057 1.00 77.85  ? 286 TYR A O   1 
ATOM 1665 C CB  . TYR A 1 286 ? 193.043 251.371 363.376 1.00 77.62  ? 286 TYR A CB  1 
ATOM 1666 C CG  . TYR A 1 286 ? 192.604 249.926 363.325 1.00 76.41  ? 286 TYR A CG  1 
ATOM 1667 C CD1 . TYR A 1 286 ? 191.609 249.449 364.169 1.00 74.41  ? 286 TYR A CD1 1 
ATOM 1668 C CD2 . TYR A 1 286 ? 193.178 249.040 362.428 1.00 78.02  ? 286 TYR A CD2 1 
ATOM 1669 C CE1 . TYR A 1 286 ? 191.207 248.130 364.123 1.00 75.23  ? 286 TYR A CE1 1 
ATOM 1670 C CE2 . TYR A 1 286 ? 192.781 247.722 362.375 1.00 76.12  ? 286 TYR A CE2 1 
ATOM 1671 C CZ  . TYR A 1 286 ? 191.796 247.271 363.224 1.00 75.02  ? 286 TYR A CZ  1 
ATOM 1672 O OH  . TYR A 1 286 ? 191.400 245.956 363.172 1.00 73.42  ? 286 TYR A OH  1 
ATOM 1673 N N   . TYR B 2 32  ? 217.012 269.526 326.883 1.00 81.62  ? 32  TYR B N   1 
ATOM 1674 C CA  . TYR B 2 32  ? 217.980 270.423 327.500 1.00 84.00  ? 32  TYR B CA  1 
ATOM 1675 C C   . TYR B 2 32  ? 218.948 269.655 328.386 1.00 85.41  ? 32  TYR B C   1 
ATOM 1676 O O   . TYR B 2 32  ? 220.160 269.851 328.309 1.00 82.57  ? 32  TYR B O   1 
ATOM 1677 C CB  . TYR B 2 32  ? 217.276 271.495 328.336 1.00 83.48  ? 32  TYR B CB  1 
ATOM 1678 C CG  . TYR B 2 32  ? 216.379 272.431 327.560 1.00 83.22  ? 32  TYR B CG  1 
ATOM 1679 C CD1 . TYR B 2 32  ? 216.444 272.515 326.177 1.00 84.27  ? 32  TYR B CD1 1 
ATOM 1680 C CD2 . TYR B 2 32  ? 215.470 273.240 328.218 1.00 82.39  ? 32  TYR B CD2 1 
ATOM 1681 C CE1 . TYR B 2 32  ? 215.626 273.374 325.479 1.00 83.05  ? 32  TYR B CE1 1 
ATOM 1682 C CE2 . TYR B 2 32  ? 214.650 274.099 327.526 1.00 85.10  ? 32  TYR B CE2 1 
ATOM 1683 C CZ  . TYR B 2 32  ? 214.731 274.164 326.160 1.00 85.53  ? 32  TYR B CZ  1 
ATOM 1684 O OH  . TYR B 2 32  ? 213.909 275.026 325.472 1.00 85.98  ? 32  TYR B OH  1 
ATOM 1685 N N   . TYR B 2 33  ? 218.402 268.788 329.234 1.00 88.71  ? 33  TYR B N   1 
ATOM 1686 C CA  . TYR B 2 33  ? 219.176 268.040 330.213 1.00 88.75  ? 33  TYR B CA  1 
ATOM 1687 C C   . TYR B 2 33  ? 219.186 266.565 329.838 1.00 88.85  ? 33  TYR B C   1 
ATOM 1688 O O   . TYR B 2 33  ? 218.169 266.019 329.400 1.00 86.00  ? 33  TYR B O   1 
ATOM 1689 C CB  . TYR B 2 33  ? 218.597 268.214 331.620 1.00 85.88  ? 33  TYR B CB  1 
ATOM 1690 C CG  . TYR B 2 33  ? 218.225 269.635 331.973 1.00 83.49  ? 33  TYR B CG  1 
ATOM 1691 C CD1 . TYR B 2 33  ? 219.154 270.500 332.534 1.00 86.25  ? 33  TYR B CD1 1 
ATOM 1692 C CD2 . TYR B 2 33  ? 216.941 270.109 331.759 1.00 84.35  ? 33  TYR B CD2 1 
ATOM 1693 C CE1 . TYR B 2 33  ? 218.814 271.802 332.865 1.00 84.71  ? 33  TYR B CE1 1 
ATOM 1694 C CE2 . TYR B 2 33  ? 216.590 271.407 332.086 1.00 86.33  ? 33  TYR B CE2 1 
ATOM 1695 C CZ  . TYR B 2 33  ? 217.530 272.250 332.639 1.00 87.28  ? 33  TYR B CZ  1 
ATOM 1696 O OH  . TYR B 2 33  ? 217.182 273.542 332.964 1.00 82.06  ? 33  TYR B OH  1 
ATOM 1697 N N   . ARG B 2 34  ? 220.340 265.919 330.020 1.00 97.42  ? 34  ARG B N   1 
ATOM 1698 C CA  . ARG B 2 34  ? 220.480 264.524 329.616 1.00 99.03  ? 34  ARG B CA  1 
ATOM 1699 C C   . ARG B 2 34  ? 219.890 263.576 330.655 1.00 100.94 ? 34  ARG B C   1 
ATOM 1700 O O   . ARG B 2 34  ? 219.171 262.634 330.303 1.00 99.92  ? 34  ARG B O   1 
ATOM 1701 C CB  . ARG B 2 34  ? 221.951 264.200 329.360 1.00 97.38  ? 34  ARG B CB  1 
ATOM 1702 C CG  . ARG B 2 34  ? 222.631 265.154 328.383 1.00 100.31 ? 34  ARG B CG  1 
ATOM 1703 C CD  . ARG B 2 34  ? 221.730 265.487 327.200 1.00 100.52 ? 34  ARG B CD  1 
ATOM 1704 N NE  . ARG B 2 34  ? 222.463 266.105 326.101 1.00 100.84 ? 34  ARG B NE  1 
ATOM 1705 C CZ  . ARG B 2 34  ? 223.063 265.434 325.128 1.00 99.07  ? 34  ARG B CZ  1 
ATOM 1706 N NH1 . ARG B 2 34  ? 223.047 264.112 325.084 1.00 97.87  ? 34  ARG B NH1 1 
ATOM 1707 N NH2 . ARG B 2 34  ? 223.697 266.108 324.172 1.00 99.53  ? 34  ARG B NH2 1 
ATOM 1708 N N   . ASP B 2 35  ? 220.186 263.794 331.934 1.00 92.41  ? 35  ASP B N   1 
ATOM 1709 C CA  . ASP B 2 35  ? 219.539 263.003 332.972 1.00 89.93  ? 35  ASP B CA  1 
ATOM 1710 C C   . ASP B 2 35  ? 218.035 263.243 332.936 1.00 89.88  ? 35  ASP B C   1 
ATOM 1711 O O   . ASP B 2 35  ? 217.575 264.388 332.900 1.00 85.46  ? 35  ASP B O   1 
ATOM 1712 C CB  . ASP B 2 35  ? 220.112 263.343 334.350 1.00 87.05  ? 35  ASP B CB  1 
ATOM 1713 C CG  . ASP B 2 35  ? 220.285 264.829 334.566 1.00 89.61  ? 35  ASP B CG  1 
ATOM 1714 O OD1 . ASP B 2 35  ? 220.159 265.593 333.586 1.00 92.64  ? 35  ASP B OD1 1 
ATOM 1715 O OD2 . ASP B 2 35  ? 220.550 265.234 335.717 1.00 85.29  ? 35  ASP B OD2 1 
ATOM 1716 N N   . SER B 2 36  ? 217.266 262.153 332.950 1.00 87.75  ? 36  SER B N   1 
ATOM 1717 C CA  . SER B 2 36  ? 215.837 262.190 332.665 1.00 86.60  ? 36  SER B CA  1 
ATOM 1718 C C   . SER B 2 36  ? 214.984 262.239 333.929 1.00 85.80  ? 36  SER B C   1 
ATOM 1719 O O   . SER B 2 36  ? 213.885 261.673 333.955 1.00 83.85  ? 36  SER B O   1 
ATOM 1720 C CB  . SER B 2 36  ? 215.441 260.988 331.812 1.00 87.30  ? 36  SER B CB  1 
ATOM 1721 O OG  . SER B 2 36  ? 214.051 260.995 331.548 1.00 90.73  ? 36  SER B OG  1 
ATOM 1722 N N   . ALA B 2 37  ? 215.468 262.895 334.983 1.00 76.15  ? 37  ALA B N   1 
ATOM 1723 C CA  . ALA B 2 37  ? 214.629 263.134 336.149 1.00 75.40  ? 37  ALA B CA  1 
ATOM 1724 C C   . ALA B 2 37  ? 213.612 264.241 335.913 1.00 75.32  ? 37  ALA B C   1 
ATOM 1725 O O   . ALA B 2 37  ? 212.676 264.380 336.707 1.00 72.77  ? 37  ALA B O   1 
ATOM 1726 C CB  . ALA B 2 37  ? 215.496 263.483 337.360 1.00 68.79  ? 37  ALA B CB  1 
ATOM 1727 N N   . SER B 2 38  ? 213.769 265.023 334.844 1.00 79.05  ? 38  SER B N   1 
ATOM 1728 C CA  . SER B 2 38  ? 212.869 266.141 334.566 1.00 79.65  ? 38  SER B CA  1 
ATOM 1729 C C   . SER B 2 38  ? 212.899 266.388 333.061 1.00 77.71  ? 38  SER B C   1 
ATOM 1730 O O   . SER B 2 38  ? 213.882 266.921 332.538 1.00 77.41  ? 38  SER B O   1 
ATOM 1731 C CB  . SER B 2 38  ? 213.282 267.384 335.343 1.00 77.37  ? 38  SER B CB  1 
ATOM 1732 O OG  . SER B 2 38  ? 214.609 267.767 335.022 1.00 74.51  ? 38  SER B OG  1 
ATOM 1733 N N   . ASN B 2 39  ? 211.826 265.993 332.377 1.00 81.08  ? 39  ASN B N   1 
ATOM 1734 C CA  . ASN B 2 39  ? 211.681 266.204 330.941 1.00 83.78  ? 39  ASN B CA  1 
ATOM 1735 C C   . ASN B 2 39  ? 210.405 266.975 330.622 1.00 86.02  ? 39  ASN B C   1 
ATOM 1736 O O   . ASN B 2 39  ? 209.847 266.840 329.532 1.00 89.06  ? 39  ASN B O   1 
ATOM 1737 C CB  . ASN B 2 39  ? 211.700 264.870 330.198 1.00 83.28  ? 39  ASN B CB  1 
ATOM 1738 C CG  . ASN B 2 39  ? 213.089 264.287 330.088 1.00 86.41  ? 39  ASN B CG  1 
ATOM 1739 O OD1 . ASN B 2 39  ? 213.377 263.231 330.647 1.00 86.75  ? 39  ASN B OD1 1 
ATOM 1740 N ND2 . ASN B 2 39  ? 213.962 264.973 329.360 1.00 86.27  ? 39  ASN B ND2 1 
ATOM 1741 N N   . ALA B 2 40  ? 209.940 267.791 331.566 1.00 79.12  ? 40  ALA B N   1 
ATOM 1742 C CA  . ALA B 2 40  ? 208.726 268.600 331.468 1.00 76.55  ? 40  ALA B CA  1 
ATOM 1743 C C   . ALA B 2 40  ? 207.464 267.762 331.610 1.00 75.82  ? 40  ALA B C   1 
ATOM 1744 O O   . ALA B 2 40  ? 206.376 268.247 331.268 1.00 74.72  ? 40  ALA B O   1 
ATOM 1745 C CB  . ALA B 2 40  ? 208.647 269.380 330.152 1.00 71.26  ? 40  ALA B CB  1 
ATOM 1746 N N   . ALA B 2 41  ? 207.564 266.531 332.102 1.00 69.07  ? 41  ALA B N   1 
ATOM 1747 C CA  . ALA B 2 41  ? 206.393 265.685 332.299 1.00 71.48  ? 41  ALA B CA  1 
ATOM 1748 C C   . ALA B 2 41  ? 206.106 265.523 333.785 1.00 69.96  ? 41  ALA B C   1 
ATOM 1749 O O   . ALA B 2 41  ? 204.970 265.681 334.231 1.00 66.69  ? 41  ALA B O   1 
ATOM 1750 C CB  . ALA B 2 41  ? 206.599 264.329 331.648 1.00 71.43  ? 41  ALA B CB  1 
ATOM 1751 N N   . SER B 2 51  ? 189.516 244.428 332.861 1.00 74.70  ? 51  SER B N   1 
ATOM 1752 C CA  . SER B 2 51  ? 189.105 243.035 332.750 1.00 80.66  ? 51  SER B CA  1 
ATOM 1753 C C   . SER B 2 51  ? 190.059 242.138 333.526 1.00 81.84  ? 51  SER B C   1 
ATOM 1754 O O   . SER B 2 51  ? 189.658 241.107 334.065 1.00 77.66  ? 51  SER B O   1 
ATOM 1755 C CB  . SER B 2 51  ? 189.054 242.605 331.284 1.00 79.86  ? 51  SER B CB  1 
ATOM 1756 O OG  . SER B 2 51  ? 190.324 242.740 330.671 1.00 80.68  ? 51  SER B OG  1 
ATOM 1757 N N   . LYS B 2 52  ? 191.330 242.541 333.569 1.00 79.91  ? 52  LYS B N   1 
ATOM 1758 C CA  . LYS B 2 52  ? 192.357 241.795 334.285 1.00 72.05  ? 52  LYS B CA  1 
ATOM 1759 C C   . LYS B 2 52  ? 192.373 242.101 335.776 1.00 72.27  ? 52  LYS B C   1 
ATOM 1760 O O   . LYS B 2 52  ? 193.099 241.436 336.520 1.00 70.39  ? 52  LYS B O   1 
ATOM 1761 C CB  . LYS B 2 52  ? 193.728 242.099 333.676 1.00 70.99  ? 52  LYS B CB  1 
ATOM 1762 C CG  . LYS B 2 52  ? 194.836 241.158 334.111 1.00 73.03  ? 52  LYS B CG  1 
ATOM 1763 C CD  . LYS B 2 52  ? 196.164 241.492 333.439 1.00 74.64  ? 52  LYS B CD  1 
ATOM 1764 C CE  . LYS B 2 52  ? 196.172 241.134 331.958 1.00 76.25  ? 52  LYS B CE  1 
ATOM 1765 N NZ  . LYS B 2 52  ? 195.981 239.676 331.716 1.00 77.02  ? 52  LYS B NZ  1 
ATOM 1766 N N   . PHE B 2 53  ? 191.595 243.084 336.228 1.00 73.06  ? 53  PHE B N   1 
ATOM 1767 C CA  . PHE B 2 53  ? 191.529 243.430 337.641 1.00 72.30  ? 53  PHE B CA  1 
ATOM 1768 C C   . PHE B 2 53  ? 190.433 242.684 338.382 1.00 71.59  ? 53  PHE B C   1 
ATOM 1769 O O   . PHE B 2 53  ? 190.572 242.428 339.583 1.00 71.86  ? 53  PHE B O   1 
ATOM 1770 C CB  . PHE B 2 53  ? 191.285 244.932 337.809 1.00 75.73  ? 53  PHE B CB  1 
ATOM 1771 C CG  . PHE B 2 53  ? 192.325 245.793 337.163 1.00 75.60  ? 53  PHE B CG  1 
ATOM 1772 C CD1 . PHE B 2 53  ? 192.201 246.175 335.839 1.00 72.88  ? 53  PHE B CD1 1 
ATOM 1773 C CD2 . PHE B 2 53  ? 193.423 246.228 337.880 1.00 72.93  ? 53  PHE B CD2 1 
ATOM 1774 C CE1 . PHE B 2 53  ? 193.155 246.969 335.243 1.00 73.41  ? 53  PHE B CE1 1 
ATOM 1775 C CE2 . PHE B 2 53  ? 194.378 247.020 337.290 1.00 71.94  ? 53  PHE B CE2 1 
ATOM 1776 C CZ  . PHE B 2 53  ? 194.245 247.392 335.969 1.00 73.35  ? 53  PHE B CZ  1 
ATOM 1777 N N   . THR B 2 54  ? 189.346 242.333 337.698 1.00 72.57  ? 54  THR B N   1 
ATOM 1778 C CA  . THR B 2 54  ? 188.158 241.780 338.346 1.00 73.93  ? 54  THR B CA  1 
ATOM 1779 C C   . THR B 2 54  ? 188.210 240.251 338.372 1.00 74.57  ? 54  THR B C   1 
ATOM 1780 O O   . THR B 2 54  ? 187.344 239.558 337.840 1.00 70.47  ? 54  THR B O   1 
ATOM 1781 C CB  . THR B 2 54  ? 186.903 242.272 337.637 1.00 75.03  ? 54  THR B CB  1 
ATOM 1782 O OG1 . THR B 2 54  ? 186.898 241.789 336.288 1.00 78.36  ? 54  THR B OG1 1 
ATOM 1783 C CG2 . THR B 2 54  ? 186.853 243.792 337.628 1.00 71.51  ? 54  THR B CG2 1 
ATOM 1784 N N   . GLU B 2 55  ? 189.254 239.732 339.019 1.00 73.35  ? 55  GLU B N   1 
ATOM 1785 C CA  . GLU B 2 55  ? 189.402 238.302 339.259 1.00 71.40  ? 55  GLU B CA  1 
ATOM 1786 C C   . GLU B 2 55  ? 189.082 237.501 338.003 1.00 74.83  ? 55  GLU B C   1 
ATOM 1787 O O   . GLU B 2 55  ? 188.027 236.858 337.928 1.00 72.86  ? 55  GLU B O   1 
ATOM 1788 C CB  . GLU B 2 55  ? 188.497 237.858 340.410 1.00 71.13  ? 55  GLU B CB  1 
ATOM 1789 C CG  . GLU B 2 55  ? 188.902 238.399 341.771 1.00 65.37  ? 55  GLU B CG  1 
ATOM 1790 C CD  . GLU B 2 55  ? 188.585 239.871 341.940 1.00 74.10  ? 55  GLU B CD  1 
ATOM 1791 O OE1 . GLU B 2 55  ? 187.569 240.330 341.381 1.00 77.05  ? 55  GLU B OE1 1 
ATOM 1792 O OE2 . GLU B 2 55  ? 189.354 240.574 342.627 1.00 76.04  ? 55  GLU B OE2 1 
ATOM 1793 N N   . PRO B 2 56  ? 189.953 237.520 336.997 1.00 77.09  ? 56  PRO B N   1 
ATOM 1794 C CA  . PRO B 2 56  ? 189.659 236.793 335.757 1.00 77.10  ? 56  PRO B CA  1 
ATOM 1795 C C   . PRO B 2 56  ? 189.497 235.300 335.996 1.00 79.75  ? 56  PRO B C   1 
ATOM 1796 O O   . PRO B 2 56  ? 190.137 234.713 336.869 1.00 78.65  ? 56  PRO B O   1 
ATOM 1797 C CB  . PRO B 2 56  ? 190.878 237.088 334.877 1.00 75.34  ? 56  PRO B CB  1 
ATOM 1798 C CG  . PRO B 2 56  ? 191.454 238.337 335.432 1.00 75.37  ? 56  PRO B CG  1 
ATOM 1799 C CD  . PRO B 2 56  ? 191.204 238.286 336.902 1.00 74.06  ? 56  PRO B CD  1 
ATOM 1800 N N   . ILE B 2 57  ? 188.618 234.689 335.208 1.00 91.26  ? 57  ILE B N   1 
ATOM 1801 C CA  . ILE B 2 57  ? 188.443 233.242 335.234 1.00 89.91  ? 57  ILE B CA  1 
ATOM 1802 C C   . ILE B 2 57  ? 189.544 232.590 334.407 1.00 90.24  ? 57  ILE B C   1 
ATOM 1803 O O   . ILE B 2 57  ? 190.149 233.215 333.529 1.00 92.32  ? 57  ILE B O   1 
ATOM 1804 C CB  . ILE B 2 57  ? 187.040 232.849 334.726 1.00 90.35  ? 57  ILE B CB  1 
ATOM 1805 C CG1 . ILE B 2 57  ? 186.836 231.338 334.832 1.00 89.69  ? 57  ILE B CG1 1 
ATOM 1806 C CG2 . ILE B 2 57  ? 186.844 233.296 333.290 1.00 91.33  ? 57  ILE B CG2 1 
ATOM 1807 C CD1 . ILE B 2 57  ? 185.406 230.899 334.636 1.00 88.45  ? 57  ILE B CD1 1 
ATOM 1808 N N   . LYS B 2 58  ? 189.808 231.314 334.694 1.00 94.08  ? 58  LYS B N   1 
ATOM 1809 C CA  . LYS B 2 58  ? 190.922 230.622 334.054 1.00 96.13  ? 58  LYS B CA  1 
ATOM 1810 C C   . LYS B 2 58  ? 190.742 230.545 332.542 1.00 97.07  ? 58  LYS B C   1 
ATOM 1811 O O   . LYS B 2 58  ? 191.692 230.773 331.785 1.00 97.54  ? 58  LYS B O   1 
ATOM 1812 C CB  . LYS B 2 58  ? 191.067 229.222 334.648 1.00 94.80  ? 58  LYS B CB  1 
ATOM 1813 C CG  . LYS B 2 58  ? 192.327 228.496 334.223 1.00 94.02  ? 58  LYS B CG  1 
ATOM 1814 C CD  . LYS B 2 58  ? 192.034 227.059 333.841 1.00 95.49  ? 58  LYS B CD  1 
ATOM 1815 C CE  . LYS B 2 58  ? 193.250 226.390 333.229 1.00 96.69  ? 58  LYS B CE  1 
ATOM 1816 N NZ  . LYS B 2 58  ? 192.932 225.028 332.721 1.00 97.80  ? 58  LYS B NZ  1 
ATOM 1817 N N   . ASP B 2 59  ? 189.530 230.229 332.081 1.00 102.29 ? 59  ASP B N   1 
ATOM 1818 C CA  . ASP B 2 59  ? 189.307 230.024 330.653 1.00 102.99 ? 59  ASP B CA  1 
ATOM 1819 C C   . ASP B 2 59  ? 189.568 231.279 329.830 1.00 104.09 ? 59  ASP B C   1 
ATOM 1820 O O   . ASP B 2 59  ? 189.843 231.168 328.630 1.00 103.16 ? 59  ASP B O   1 
ATOM 1821 C CB  . ASP B 2 59  ? 187.875 229.547 330.407 1.00 102.19 ? 59  ASP B CB  1 
ATOM 1822 C CG  . ASP B 2 59  ? 187.635 228.141 330.912 1.00 102.47 ? 59  ASP B CG  1 
ATOM 1823 O OD1 . ASP B 2 59  ? 187.721 227.925 332.138 1.00 103.32 ? 59  ASP B OD1 1 
ATOM 1824 O OD2 . ASP B 2 59  ? 187.357 227.251 330.083 1.00 101.10 ? 59  ASP B OD2 1 
ATOM 1825 N N   . VAL B 2 60  ? 189.486 232.464 330.436 1.00 102.51 ? 60  VAL B N   1 
ATOM 1826 C CA  . VAL B 2 60  ? 189.642 233.703 329.675 1.00 100.70 ? 60  VAL B CA  1 
ATOM 1827 C C   . VAL B 2 60  ? 191.011 233.748 329.008 1.00 100.65 ? 60  VAL B C   1 
ATOM 1828 O O   . VAL B 2 60  ? 191.123 233.770 327.777 1.00 100.10 ? 60  VAL B O   1 
ATOM 1829 C CB  . VAL B 2 60  ? 189.424 234.925 330.584 1.00 99.74  ? 60  VAL B CB  1 
ATOM 1830 C CG1 . VAL B 2 60  ? 190.028 236.177 329.957 1.00 99.44  ? 60  VAL B CG1 1 
ATOM 1831 C CG2 . VAL B 2 60  ? 187.943 235.130 330.845 1.00 97.94  ? 60  VAL B CG2 1 
ATOM 1832 N N   . LEU B 2 61  ? 192.072 233.767 329.812 1.00 94.91  ? 61  LEU B N   1 
ATOM 1833 C CA  . LEU B 2 61  ? 193.417 233.940 329.278 1.00 95.28  ? 61  LEU B CA  1 
ATOM 1834 C C   . LEU B 2 61  ? 194.121 232.606 329.051 1.00 97.32  ? 61  LEU B C   1 
ATOM 1835 O O   . LEU B 2 61  ? 194.493 232.282 327.919 1.00 95.16  ? 61  LEU B O   1 
ATOM 1836 C CB  . LEU B 2 61  ? 194.239 234.817 330.224 1.00 93.19  ? 61  LEU B CB  1 
ATOM 1837 C CG  . LEU B 2 61  ? 195.638 235.211 329.747 1.00 95.33  ? 61  LEU B CG  1 
ATOM 1838 C CD1 . LEU B 2 61  ? 195.568 236.053 328.483 1.00 93.91  ? 61  LEU B CD1 1 
ATOM 1839 C CD2 . LEU B 2 61  ? 196.384 235.952 330.845 1.00 94.37  ? 61  LEU B CD2 1 
ATOM 1840 N N   . ILE B 2 62  ? 194.300 231.822 330.114 1.00 97.80  ? 62  ILE B N   1 
ATOM 1841 C CA  . ILE B 2 62  ? 195.084 230.585 330.050 1.00 95.08  ? 62  ILE B CA  1 
ATOM 1842 C C   . ILE B 2 62  ? 194.103 229.431 330.232 1.00 97.07  ? 62  ILE B C   1 
ATOM 1843 O O   . ILE B 2 62  ? 193.665 229.127 331.339 1.00 98.31  ? 62  ILE B O   1 
ATOM 1844 C CB  . ILE B 2 62  ? 196.198 230.560 331.094 1.00 94.28  ? 62  ILE B CB  1 
ATOM 1845 C CG1 . ILE B 2 62  ? 197.025 231.846 331.031 1.00 92.65  ? 62  ILE B CG1 1 
ATOM 1846 C CG2 . ILE B 2 62  ? 197.094 229.348 330.884 1.00 95.80  ? 62  ILE B CG2 1 
ATOM 1847 C CD1 . ILE B 2 62  ? 196.764 232.789 332.184 1.00 91.44  ? 62  ILE B CD1 1 
ATOM 1848 N N   . LYS B 2 63  ? 193.763 228.770 329.125 1.00 105.46 ? 63  LYS B N   1 
ATOM 1849 C CA  . LYS B 2 63  ? 192.920 227.582 329.161 1.00 104.68 ? 63  LYS B CA  1 
ATOM 1850 C C   . LYS B 2 63  ? 193.679 226.305 328.834 1.00 104.11 ? 63  LYS B C   1 
ATOM 1851 O O   . LYS B 2 63  ? 193.198 225.216 329.162 1.00 102.45 ? 63  LYS B O   1 
ATOM 1852 C CB  . LYS B 2 63  ? 191.747 227.732 328.185 1.00 103.81 ? 63  LYS B CB  1 
ATOM 1853 C CG  . LYS B 2 63  ? 190.857 226.495 328.072 1.00 103.09 ? 63  LYS B CG  1 
ATOM 1854 C CD  . LYS B 2 63  ? 190.317 226.053 329.427 1.00 103.80 ? 63  LYS B CD  1 
ATOM 1855 C CE  . LYS B 2 63  ? 189.498 224.777 329.317 1.00 105.02 ? 63  LYS B CE  1 
ATOM 1856 N NZ  . LYS B 2 63  ? 190.341 223.605 328.954 1.00 104.66 ? 63  LYS B NZ  1 
ATOM 1857 N N   . THR B 2 64  ? 194.848 226.410 328.206 1.00 109.23 ? 64  THR B N   1 
ATOM 1858 C CA  . THR B 2 64  ? 195.653 225.250 327.850 1.00 111.67 ? 64  THR B CA  1 
ATOM 1859 C C   . THR B 2 64  ? 196.487 224.731 329.012 1.00 111.39 ? 64  THR B C   1 
ATOM 1860 O O   . THR B 2 64  ? 197.397 223.924 328.791 1.00 108.85 ? 64  THR B O   1 
ATOM 1861 C CB  . THR B 2 64  ? 196.571 225.589 326.673 1.00 110.96 ? 64  THR B CB  1 
ATOM 1862 O OG1 . THR B 2 64  ? 197.226 224.399 326.217 1.00 110.12 ? 64  THR B OG1 1 
ATOM 1863 C CG2 . THR B 2 64  ? 197.621 226.613 327.087 1.00 108.97 ? 64  THR B CG2 1 
ATOM 1864 N N   . ALA B 2 65  ? 196.201 225.166 330.238 1.00 104.44 ? 65  ALA B N   1 
ATOM 1865 C CA  . ALA B 2 65  ? 196.969 224.737 331.397 1.00 103.42 ? 65  ALA B CA  1 
ATOM 1866 C C   . ALA B 2 65  ? 196.073 224.125 332.466 1.00 103.45 ? 65  ALA B C   1 
ATOM 1867 O O   . ALA B 2 65  ? 196.106 224.567 333.621 1.00 102.97 ? 65  ALA B O   1 
ATOM 1868 C CB  . ALA B 2 65  ? 197.745 225.919 331.981 1.00 101.70 ? 65  ALA B CB  1 
ATOM 1869 N N   . PRO B 2 66  ? 195.247 223.107 332.133 1.00 106.08 ? 66  PRO B N   1 
ATOM 1870 C CA  . PRO B 2 66  ? 194.548 222.325 333.158 1.00 103.20 ? 66  PRO B CA  1 
ATOM 1871 C C   . PRO B 2 66  ? 195.410 221.187 333.701 1.00 102.41 ? 66  PRO B C   1 
ATOM 1872 O O   . PRO B 2 66  ? 194.960 220.044 333.831 1.00 99.78  ? 66  PRO B O   1 
ATOM 1873 C CB  . PRO B 2 66  ? 193.318 221.808 332.406 1.00 100.71 ? 66  PRO B CB  1 
ATOM 1874 C CG  . PRO B 2 66  ? 193.818 221.608 331.025 1.00 103.94 ? 66  PRO B CG  1 
ATOM 1875 C CD  . PRO B 2 66  ? 194.825 222.707 330.777 1.00 103.90 ? 66  PRO B CD  1 
ATOM 1876 N N   . MET B 2 67  ? 196.668 221.497 334.018 1.00 101.59 ? 67  MET B N   1 
ATOM 1877 C CA  . MET B 2 67  ? 197.585 220.505 334.560 1.00 100.40 ? 67  MET B CA  1 
ATOM 1878 C C   . MET B 2 67  ? 197.275 220.155 336.006 1.00 101.37 ? 67  MET B C   1 
ATOM 1879 O O   . MET B 2 67  ? 197.893 219.235 336.551 1.00 99.88  ? 67  MET B O   1 
ATOM 1880 C CB  . MET B 2 67  ? 199.025 221.008 334.446 1.00 100.63 ? 67  MET B CB  1 
ATOM 1881 C CG  . MET B 2 67  ? 199.305 222.295 335.205 1.00 100.69 ? 67  MET B CG  1 
ATOM 1882 S SD  . MET B 2 67  ? 200.814 223.101 334.638 1.00 107.39 ? 67  MET B SD  1 
ATOM 1883 C CE  . MET B 2 67  ? 200.828 224.565 335.665 1.00 99.25  ? 67  MET B CE  1 
ATOM 1884 N N   . LEU B 2 68  ? 196.333 220.858 336.634 1.00 98.11  ? 68  LEU B N   1 
ATOM 1885 C CA  . LEU B 2 68  ? 195.946 220.552 338.004 1.00 94.21  ? 68  LEU B CA  1 
ATOM 1886 C C   . LEU B 2 68  ? 195.221 219.218 338.110 1.00 97.04  ? 68  LEU B C   1 
ATOM 1887 O O   . LEU B 2 68  ? 194.964 218.761 339.229 1.00 97.29  ? 68  LEU B O   1 
ATOM 1888 C CB  . LEU B 2 68  ? 195.055 221.662 338.571 1.00 93.11  ? 68  LEU B CB  1 
ATOM 1889 C CG  . LEU B 2 68  ? 195.157 223.074 337.978 1.00 92.65  ? 68  LEU B CG  1 
ATOM 1890 C CD1 . LEU B 2 68  ? 194.266 224.038 338.745 1.00 92.26  ? 68  LEU B CD1 1 
ATOM 1891 C CD2 . LEU B 2 68  ? 196.592 223.579 337.958 1.00 93.30  ? 68  LEU B CD2 1 
ATOM 1892 N N   . ASN B 2 69  ? 194.876 218.601 336.983 1.00 99.47  ? 69  ASN B N   1 
ATOM 1893 C CA  . ASN B 2 69  ? 194.162 217.330 336.962 1.00 97.71  ? 69  ASN B CA  1 
ATOM 1894 C C   . ASN B 2 69  ? 192.748 217.528 337.487 1.00 97.50  ? 69  ASN B C   1 
ATOM 1895 O O   . ASN B 2 69  ? 192.059 218.467 337.086 1.00 97.30  ? 69  ASN B O   1 
ATOM 1896 C CB  . ASN B 2 69  ? 194.896 216.271 337.788 1.00 96.48  ? 69  ASN B CB  1 
ATOM 1897 C CG  . ASN B 2 69  ? 196.352 216.126 337.389 1.00 98.17  ? 69  ASN B CG  1 
ATOM 1898 O OD1 . ASN B 2 69  ? 196.710 216.300 336.225 1.00 97.80  ? 69  ASN B OD1 1 
ATOM 1899 N ND2 . ASN B 2 69  ? 197.201 215.806 338.358 1.00 96.96  ? 69  ASN B ND2 1 
ATOM 1900 N N   . THR B 2 91  ? 195.299 215.282 342.217 1.00 97.56  ? 91  THR B N   1 
ATOM 1901 C CA  . THR B 2 91  ? 194.000 215.216 341.558 1.00 101.83 ? 91  THR B CA  1 
ATOM 1902 C C   . THR B 2 91  ? 192.888 215.384 342.583 1.00 99.36  ? 91  THR B C   1 
ATOM 1903 O O   . THR B 2 91  ? 192.039 214.508 342.742 1.00 98.16  ? 91  THR B O   1 
ATOM 1904 C CB  . THR B 2 91  ? 193.807 213.882 340.813 1.00 102.60 ? 91  THR B CB  1 
ATOM 1905 O OG1 . THR B 2 91  ? 194.971 213.594 340.031 1.00 102.96 ? 91  THR B OG1 1 
ATOM 1906 C CG2 . THR B 2 91  ? 192.595 213.950 339.895 1.00 100.01 ? 91  THR B CG2 1 
ATOM 1907 N N   . ILE B 2 92  ? 192.894 216.520 343.281 1.00 77.04  ? 92  ILE B N   1 
ATOM 1908 C CA  . ILE B 2 92  ? 191.933 216.725 344.357 1.00 78.87  ? 92  ILE B CA  1 
ATOM 1909 C C   . ILE B 2 92  ? 190.565 217.150 343.836 1.00 79.45  ? 92  ILE B C   1 
ATOM 1910 O O   . ILE B 2 92  ? 189.561 216.969 344.536 1.00 72.90  ? 92  ILE B O   1 
ATOM 1911 C CB  . ILE B 2 92  ? 192.492 217.746 345.363 1.00 76.44  ? 92  ILE B CB  1 
ATOM 1912 C CG1 . ILE B 2 92  ? 192.406 217.183 346.782 1.00 73.31  ? 92  ILE B CG1 1 
ATOM 1913 C CG2 . ILE B 2 92  ? 191.768 219.088 345.266 1.00 72.56  ? 92  ILE B CG2 1 
ATOM 1914 C CD1 . ILE B 2 92  ? 193.339 216.016 347.031 1.00 66.51  ? 92  ILE B CD1 1 
ATOM 1915 N N   . THR B 2 93  ? 190.491 217.710 342.631 1.00 90.77  ? 93  THR B N   1 
ATOM 1916 C CA  . THR B 2 93  ? 189.207 218.059 342.041 1.00 91.88  ? 93  THR B CA  1 
ATOM 1917 C C   . THR B 2 93  ? 189.371 218.168 340.534 1.00 91.57  ? 93  THR B C   1 
ATOM 1918 O O   . THR B 2 93  ? 190.441 218.517 340.031 1.00 91.06  ? 93  THR B O   1 
ATOM 1919 C CB  . THR B 2 93  ? 188.658 219.366 342.621 1.00 90.45  ? 93  THR B CB  1 
ATOM 1920 O OG1 . THR B 2 93  ? 188.630 219.277 344.050 1.00 91.32  ? 93  THR B OG1 1 
ATOM 1921 C CG2 . THR B 2 93  ? 187.251 219.628 342.114 1.00 89.37  ? 93  THR B CG2 1 
ATOM 1922 N N   . ALA B 2 94  ? 188.288 217.859 339.821 1.00 98.35  ? 94  ALA B N   1 
ATOM 1923 C CA  . ALA B 2 94  ? 188.265 217.915 338.367 1.00 97.69  ? 94  ALA B CA  1 
ATOM 1924 C C   . ALA B 2 94  ? 186.953 218.530 337.910 1.00 98.91  ? 94  ALA B C   1 
ATOM 1925 O O   . ALA B 2 94  ? 185.899 218.275 338.499 1.00 100.26 ? 94  ALA B O   1 
ATOM 1926 C CB  . ALA B 2 94  ? 188.432 216.525 337.744 1.00 95.11  ? 94  ALA B CB  1 
ATOM 1927 N N   . GLN B 2 95  ? 187.028 219.328 336.848 1.00 102.06 ? 95  GLN B N   1 
ATOM 1928 C CA  . GLN B 2 95  ? 185.948 220.086 336.234 1.00 101.12 ? 95  GLN B CA  1 
ATOM 1929 C C   . GLN B 2 95  ? 185.595 221.326 337.054 1.00 97.68  ? 95  GLN B C   1 
ATOM 1930 O O   . GLN B 2 95  ? 184.827 222.159 336.574 1.00 96.09  ? 95  GLN B O   1 
ATOM 1931 C CB  . GLN B 2 95  ? 184.674 219.245 336.017 1.00 101.94 ? 95  GLN B CB  1 
ATOM 1932 C CG  . GLN B 2 95  ? 183.672 219.826 335.026 1.00 103.27 ? 95  GLN B CG  1 
ATOM 1933 C CD  . GLN B 2 95  ? 182.680 220.780 335.662 1.00 103.45 ? 95  GLN B CD  1 
ATOM 1934 O OE1 . GLN B 2 95  ? 182.508 220.797 336.881 1.00 102.98 ? 95  GLN B OE1 1 
ATOM 1935 N NE2 . GLN B 2 95  ? 182.021 221.583 334.834 1.00 101.55 ? 95  GLN B NE2 1 
ATOM 1936 N N   . GLU B 2 96  ? 186.148 221.499 338.255 1.00 92.05  ? 96  GLU B N   1 
ATOM 1937 C CA  . GLU B 2 96  ? 186.083 222.773 338.953 1.00 91.81  ? 96  GLU B CA  1 
ATOM 1938 C C   . GLU B 2 96  ? 187.320 223.628 338.723 1.00 94.57  ? 96  GLU B C   1 
ATOM 1939 O O   . GLU B 2 96  ? 187.357 224.772 339.183 1.00 93.08  ? 96  GLU B O   1 
ATOM 1940 C CB  . GLU B 2 96  ? 185.896 222.560 340.460 1.00 90.12  ? 96  GLU B CB  1 
ATOM 1941 C CG  . GLU B 2 96  ? 184.477 222.205 340.866 1.00 91.49  ? 96  GLU B CG  1 
ATOM 1942 C CD  . GLU B 2 96  ? 184.107 220.781 340.516 1.00 96.68  ? 96  GLU B CD  1 
ATOM 1943 O OE1 . GLU B 2 96  ? 185.004 220.017 340.110 1.00 98.33  ? 96  GLU B OE1 1 
ATOM 1944 O OE2 . GLU B 2 96  ? 182.917 220.424 340.649 1.00 95.74  ? 96  GLU B OE2 1 
ATOM 1945 N N   . ALA B 2 97  ? 188.331 223.100 338.031 1.00 98.67  ? 97  ALA B N   1 
ATOM 1946 C CA  . ALA B 2 97  ? 189.517 223.888 337.726 1.00 95.73  ? 97  ALA B CA  1 
ATOM 1947 C C   . ALA B 2 97  ? 189.255 224.923 336.644 1.00 94.91  ? 97  ALA B C   1 
ATOM 1948 O O   . ALA B 2 97  ? 190.033 225.874 336.514 1.00 94.90  ? 97  ALA B O   1 
ATOM 1949 C CB  . ALA B 2 97  ? 190.662 222.972 337.295 1.00 94.12  ? 97  ALA B CB  1 
ATOM 1950 N N   . ALA B 2 98  ? 188.189 224.761 335.866 1.00 92.95  ? 98  ALA B N   1 
ATOM 1951 C CA  . ALA B 2 98  ? 187.846 225.698 334.808 1.00 92.50  ? 98  ALA B CA  1 
ATOM 1952 C C   . ALA B 2 98  ? 186.959 226.837 335.290 1.00 92.00  ? 98  ALA B C   1 
ATOM 1953 O O   . ALA B 2 98  ? 186.694 227.764 334.518 1.00 92.14  ? 98  ALA B O   1 
ATOM 1954 C CB  . ALA B 2 98  ? 187.156 224.960 333.659 1.00 91.42  ? 98  ALA B CB  1 
ATOM 1955 N N   . ASN B 2 99  ? 186.490 226.794 336.536 1.00 86.48  ? 99  ASN B N   1 
ATOM 1956 C CA  . ASN B 2 99  ? 185.738 227.890 337.133 1.00 87.62  ? 99  ASN B CA  1 
ATOM 1957 C C   . ASN B 2 99  ? 186.535 228.569 338.245 1.00 87.43  ? 99  ASN B C   1 
ATOM 1958 O O   . ASN B 2 99  ? 185.961 229.119 339.187 1.00 86.27  ? 99  ASN B O   1 
ATOM 1959 C CB  . ASN B 2 99  ? 184.390 227.397 337.655 1.00 86.40  ? 99  ASN B CB  1 
ATOM 1960 C CG  . ASN B 2 99  ? 184.498 226.705 338.994 1.00 88.70  ? 99  ASN B CG  1 
ATOM 1961 O OD1 . ASN B 2 99  ? 184.726 225.501 339.067 1.00 88.69  ? 99  ASN B OD1 1 
ATOM 1962 N ND2 . ASN B 2 99  ? 184.325 227.467 340.068 1.00 87.79  ? 99  ASN B ND2 1 
ATOM 1963 N N   . SER B 2 100 ? 187.857 228.532 338.143 1.00 77.06  ? 100 SER B N   1 
ATOM 1964 C CA  . SER B 2 100 ? 188.748 229.138 339.118 1.00 72.62  ? 100 SER B CA  1 
ATOM 1965 C C   . SER B 2 100 ? 189.115 230.551 338.687 1.00 74.39  ? 100 SER B C   1 
ATOM 1966 O O   . SER B 2 100 ? 189.000 230.917 337.517 1.00 78.67  ? 100 SER B O   1 
ATOM 1967 C CB  . SER B 2 100 ? 190.015 228.298 339.279 1.00 73.83  ? 100 SER B CB  1 
ATOM 1968 O OG  . SER B 2 100 ? 190.716 228.214 338.052 1.00 76.87  ? 100 SER B OG  1 
ATOM 1969 N N   . VAL B 2 101 ? 189.571 231.344 339.653 1.00 63.28  ? 101 VAL B N   1 
ATOM 1970 C CA  . VAL B 2 101 ? 189.982 232.722 339.414 1.00 63.18  ? 101 VAL B CA  1 
ATOM 1971 C C   . VAL B 2 101 ? 191.500 232.787 339.451 1.00 57.46  ? 101 VAL B C   1 
ATOM 1972 O O   . VAL B 2 101 ? 192.132 232.217 340.347 1.00 59.48  ? 101 VAL B O   1 
ATOM 1973 C CB  . VAL B 2 101 ? 189.367 233.680 340.449 1.00 63.21  ? 101 VAL B CB  1 
ATOM 1974 C CG1 . VAL B 2 101 ? 187.868 233.463 340.547 1.00 63.66  ? 101 VAL B CG1 1 
ATOM 1975 C CG2 . VAL B 2 101 ? 190.030 233.510 341.804 1.00 58.70  ? 101 VAL B CG2 1 
ATOM 1976 N N   . VAL B 2 102 ? 192.085 233.467 338.473 1.00 58.51  ? 102 VAL B N   1 
ATOM 1977 C CA  . VAL B 2 102 ? 193.522 233.697 338.416 1.00 57.89  ? 102 VAL B CA  1 
ATOM 1978 C C   . VAL B 2 102 ? 193.762 235.128 338.873 1.00 59.12  ? 102 VAL B C   1 
ATOM 1979 O O   . VAL B 2 102 ? 193.379 236.078 338.186 1.00 66.89  ? 102 VAL B O   1 
ATOM 1980 C CB  . VAL B 2 102 ? 194.075 233.456 337.006 1.00 57.71  ? 102 VAL B CB  1 
ATOM 1981 C CG1 . VAL B 2 102 ? 195.589 233.419 337.028 1.00 59.32  ? 102 VAL B CG1 1 
ATOM 1982 C CG2 . VAL B 2 102 ? 193.517 232.169 336.433 1.00 59.64  ? 102 VAL B CG2 1 
ATOM 1983 N N   . ALA B 2 103 ? 194.400 235.291 340.028 1.00 54.74  ? 103 ALA B N   1 
ATOM 1984 C CA  . ALA B 2 103 ? 194.575 236.617 340.603 1.00 52.28  ? 103 ALA B CA  1 
ATOM 1985 C C   . ALA B 2 103 ? 195.302 237.534 339.631 1.00 53.33  ? 103 ALA B C   1 
ATOM 1986 O O   . ALA B 2 103 ? 196.340 237.173 339.073 1.00 54.38  ? 103 ALA B O   1 
ATOM 1987 C CB  . ALA B 2 103 ? 195.350 236.524 341.915 1.00 46.50  ? 103 ALA B CB  1 
ATOM 1988 N N   . TYR B 2 104 ? 194.746 238.726 339.423 1.00 51.53  ? 104 TYR B N   1 
ATOM 1989 C CA  . TYR B 2 104 ? 195.337 239.747 338.563 1.00 53.09  ? 104 TYR B CA  1 
ATOM 1990 C C   . TYR B 2 104 ? 195.610 239.230 337.155 1.00 53.72  ? 104 TYR B C   1 
ATOM 1991 O O   . TYR B 2 104 ? 196.390 239.831 336.412 1.00 58.34  ? 104 TYR B O   1 
ATOM 1992 C CB  . TYR B 2 104 ? 196.622 240.306 339.184 1.00 50.74  ? 104 TYR B CB  1 
ATOM 1993 C CG  . TYR B 2 104 ? 196.395 240.957 340.527 1.00 46.53  ? 104 TYR B CG  1 
ATOM 1994 C CD1 . TYR B 2 104 ? 195.411 241.913 340.692 1.00 44.15  ? 104 TYR B CD1 1 
ATOM 1995 C CD2 . TYR B 2 104 ? 197.146 240.605 341.630 1.00 47.73  ? 104 TYR B CD2 1 
ATOM 1996 C CE1 . TYR B 2 104 ? 195.189 242.504 341.910 1.00 45.13  ? 104 TYR B CE1 1 
ATOM 1997 C CE2 . TYR B 2 104 ? 196.928 241.191 342.855 1.00 47.48  ? 104 TYR B CE2 1 
ATOM 1998 C CZ  . TYR B 2 104 ? 195.947 242.141 342.988 1.00 45.03  ? 104 TYR B CZ  1 
ATOM 1999 O OH  . TYR B 2 104 ? 195.715 242.740 344.202 1.00 42.00  ? 104 TYR B OH  1 
ATOM 2000 N N   . GLY B 2 105 ? 194.979 238.126 336.771 1.00 52.75  ? 105 GLY B N   1 
ATOM 2001 C CA  . GLY B 2 105 ? 195.151 237.597 335.428 1.00 53.08  ? 105 GLY B CA  1 
ATOM 2002 C C   . GLY B 2 105 ? 196.583 237.255 335.090 1.00 58.35  ? 105 GLY B C   1 
ATOM 2003 O O   . GLY B 2 105 ? 197.009 237.445 333.945 1.00 60.63  ? 105 GLY B O   1 
ATOM 2004 N N   . ARG B 2 106 ? 197.338 236.747 336.059 1.00 57.56  ? 106 ARG B N   1 
ATOM 2005 C CA  . ARG B 2 106 ? 198.730 236.376 335.859 1.00 54.35  ? 106 ARG B CA  1 
ATOM 2006 C C   . ARG B 2 106 ? 198.939 234.950 336.336 1.00 61.21  ? 106 ARG B C   1 
ATOM 2007 O O   . ARG B 2 106 ? 198.554 234.603 337.456 1.00 61.20  ? 106 ARG B O   1 
ATOM 2008 C CB  . ARG B 2 106 ? 199.670 237.327 336.603 1.00 55.48  ? 106 ARG B CB  1 
ATOM 2009 C CG  . ARG B 2 106 ? 199.789 238.699 335.970 1.00 58.97  ? 106 ARG B CG  1 
ATOM 2010 C CD  . ARG B 2 106 ? 200.716 238.680 334.772 1.00 61.51  ? 106 ARG B CD  1 
ATOM 2011 N NE  . ARG B 2 106 ? 202.105 238.493 335.174 1.00 62.03  ? 106 ARG B NE  1 
ATOM 2012 C CZ  . ARG B 2 106 ? 202.937 239.476 335.491 1.00 58.08  ? 106 ARG B CZ  1 
ATOM 2013 N NH1 . ARG B 2 106 ? 202.562 240.743 335.447 1.00 59.40  ? 106 ARG B NH1 1 
ATOM 2014 N NH2 . ARG B 2 106 ? 204.178 239.179 335.862 1.00 59.08  ? 106 ARG B NH2 1 
ATOM 2015 N N   . TRP B 2 107 ? 199.548 234.132 335.487 1.00 70.77  ? 107 TRP B N   1 
ATOM 2016 C CA  . TRP B 2 107 ? 199.830 232.743 335.814 1.00 69.07  ? 107 TRP B CA  1 
ATOM 2017 C C   . TRP B 2 107 ? 201.216 232.625 336.440 1.00 70.23  ? 107 TRP B C   1 
ATOM 2018 O O   . TRP B 2 107 ? 202.168 233.232 335.944 1.00 71.68  ? 107 TRP B O   1 
ATOM 2019 C CB  . TRP B 2 107 ? 199.763 231.879 334.561 1.00 70.28  ? 107 TRP B CB  1 
ATOM 2020 C CG  . TRP B 2 107 ? 199.686 230.417 334.841 1.00 73.25  ? 107 TRP B CG  1 
ATOM 2021 C CD1 . TRP B 2 107 ? 200.707 229.519 334.791 1.00 72.02  ? 107 TRP B CD1 1 
ATOM 2022 C CD2 . TRP B 2 107 ? 198.520 229.679 335.214 1.00 69.83  ? 107 TRP B CD2 1 
ATOM 2023 N NE1 . TRP B 2 107 ? 200.251 228.266 335.110 1.00 72.88  ? 107 TRP B NE1 1 
ATOM 2024 C CE2 . TRP B 2 107 ? 198.909 228.338 335.375 1.00 71.75  ? 107 TRP B CE2 1 
ATOM 2025 C CE3 . TRP B 2 107 ? 197.183 230.023 335.429 1.00 68.91  ? 107 TRP B CE3 1 
ATOM 2026 C CZ2 . TRP B 2 107 ? 198.012 227.342 335.741 1.00 71.30  ? 107 TRP B CZ2 1 
ATOM 2027 C CZ3 . TRP B 2 107 ? 196.296 229.032 335.792 1.00 70.23  ? 107 TRP B CZ3 1 
ATOM 2028 C CH2 . TRP B 2 107 ? 196.712 227.709 335.943 1.00 70.16  ? 107 TRP B CH2 1 
ATOM 2029 N N   . PRO B 2 108 ? 201.385 231.869 337.525 1.00 67.70  ? 108 PRO B N   1 
ATOM 2030 C CA  . PRO B 2 108 ? 202.723 231.735 338.110 1.00 64.46  ? 108 PRO B CA  1 
ATOM 2031 C C   . PRO B 2 108 ? 203.712 231.202 337.088 1.00 66.85  ? 108 PRO B C   1 
ATOM 2032 O O   . PRO B 2 108 ? 203.385 230.340 336.272 1.00 71.45  ? 108 PRO B O   1 
ATOM 2033 C CB  . PRO B 2 108 ? 202.510 230.749 339.262 1.00 65.90  ? 108 PRO B CB  1 
ATOM 2034 C CG  . PRO B 2 108 ? 201.080 230.865 339.598 1.00 65.83  ? 108 PRO B CG  1 
ATOM 2035 C CD  . PRO B 2 108 ? 200.376 231.141 338.310 1.00 65.39  ? 108 PRO B CD  1 
ATOM 2036 N N   . GLU B 2 109 ? 204.930 231.732 337.133 1.00 71.78  ? 109 GLU B N   1 
ATOM 2037 C CA  . GLU B 2 109 ? 205.946 231.404 336.147 1.00 71.98  ? 109 GLU B CA  1 
ATOM 2038 C C   . GLU B 2 109 ? 207.315 231.397 336.808 1.00 75.43  ? 109 GLU B C   1 
ATOM 2039 O O   . GLU B 2 109 ? 207.543 232.061 337.822 1.00 72.13  ? 109 GLU B O   1 
ATOM 2040 C CB  . GLU B 2 109 ? 205.936 232.402 334.986 1.00 73.12  ? 109 GLU B CB  1 
ATOM 2041 C CG  . GLU B 2 109 ? 206.139 233.841 335.427 1.00 75.24  ? 109 GLU B CG  1 
ATOM 2042 C CD  . GLU B 2 109 ? 206.200 234.805 334.262 1.00 78.99  ? 109 GLU B CD  1 
ATOM 2043 O OE1 . GLU B 2 109 ? 206.213 234.342 333.102 1.00 81.87  ? 109 GLU B OE1 1 
ATOM 2044 O OE2 . GLU B 2 109 ? 206.235 236.028 334.508 1.00 75.40  ? 109 GLU B OE2 1 
ATOM 2045 N N   . TYR B 2 110 ? 208.229 230.641 336.208 1.00 83.28  ? 110 TYR B N   1 
ATOM 2046 C CA  . TYR B 2 110 ? 209.605 230.630 336.670 1.00 79.93  ? 110 TYR B CA  1 
ATOM 2047 C C   . TYR B 2 110 ? 210.270 231.969 336.382 1.00 78.28  ? 110 TYR B C   1 
ATOM 2048 O O   . TYR B 2 110 ? 209.810 232.760 335.556 1.00 81.01  ? 110 TYR B O   1 
ATOM 2049 C CB  . TYR B 2 110 ? 210.393 229.507 335.997 1.00 75.56  ? 110 TYR B CB  1 
ATOM 2050 C CG  . TYR B 2 110 ? 210.087 228.141 336.554 1.00 77.96  ? 110 TYR B CG  1 
ATOM 2051 C CD1 . TYR B 2 110 ? 210.600 227.742 337.778 1.00 75.89  ? 110 TYR B CD1 1 
ATOM 2052 C CD2 . TYR B 2 110 ? 209.287 227.251 335.856 1.00 79.01  ? 110 TYR B CD2 1 
ATOM 2053 C CE1 . TYR B 2 110 ? 210.322 226.498 338.292 1.00 75.36  ? 110 TYR B CE1 1 
ATOM 2054 C CE2 . TYR B 2 110 ? 209.005 226.002 336.363 1.00 77.44  ? 110 TYR B CE2 1 
ATOM 2055 C CZ  . TYR B 2 110 ? 209.524 225.631 337.581 1.00 77.94  ? 110 TYR B CZ  1 
ATOM 2056 O OH  . TYR B 2 110 ? 209.245 224.386 338.091 1.00 79.71  ? 110 TYR B OH  1 
ATOM 2057 N N   . LEU B 2 111 ? 211.367 232.220 337.085 1.00 76.54  ? 111 LEU B N   1 
ATOM 2058 C CA  . LEU B 2 111 ? 212.125 233.451 336.905 1.00 75.61  ? 111 LEU B CA  1 
ATOM 2059 C C   . LEU B 2 111 ? 212.940 233.332 335.624 1.00 80.34  ? 111 LEU B C   1 
ATOM 2060 O O   . LEU B 2 111 ? 213.930 232.596 335.574 1.00 80.06  ? 111 LEU B O   1 
ATOM 2061 C CB  . LEU B 2 111 ? 213.017 233.702 338.116 1.00 71.11  ? 111 LEU B CB  1 
ATOM 2062 C CG  . LEU B 2 111 ? 213.733 235.047 338.177 1.00 73.95  ? 111 LEU B CG  1 
ATOM 2063 C CD1 . LEU B 2 111 ? 212.744 236.186 338.043 1.00 75.12  ? 111 LEU B CD1 1 
ATOM 2064 C CD2 . LEU B 2 111 ? 214.509 235.164 339.477 1.00 73.47  ? 111 LEU B CD2 1 
ATOM 2065 N N   . ARG B 2 112 ? 212.520 234.049 334.587 1.00 95.53  ? 112 ARG B N   1 
ATOM 2066 C CA  . ARG B 2 112 ? 213.150 233.961 333.277 1.00 95.84  ? 112 ARG B CA  1 
ATOM 2067 C C   . ARG B 2 112 ? 214.473 234.724 333.295 1.00 97.82  ? 112 ARG B C   1 
ATOM 2068 O O   . ARG B 2 112 ? 214.942 235.184 334.340 1.00 97.49  ? 112 ARG B O   1 
ATOM 2069 C CB  . ARG B 2 112 ? 212.201 234.488 332.204 1.00 95.09  ? 112 ARG B CB  1 
ATOM 2070 C CG  . ARG B 2 112 ? 210.872 233.746 332.113 1.00 94.65  ? 112 ARG B CG  1 
ATOM 2071 C CD  . ARG B 2 112 ? 210.991 232.447 331.325 1.00 95.24  ? 112 ARG B CD  1 
ATOM 2072 N NE  . ARG B 2 112 ? 211.743 231.425 332.042 1.00 96.37  ? 112 ARG B NE  1 
ATOM 2073 C CZ  . ARG B 2 112 ? 212.014 230.219 331.560 1.00 96.75  ? 112 ARG B CZ  1 
ATOM 2074 N NH1 . ARG B 2 112 ? 211.607 229.847 330.358 1.00 95.38  ? 112 ARG B NH1 1 
ATOM 2075 N NH2 . ARG B 2 112 ? 212.712 229.366 332.303 1.00 96.63  ? 112 ARG B NH2 1 
ATOM 2076 N N   . ASP B 2 113 ? 215.095 234.861 332.128 1.00 107.34 ? 113 ASP B N   1 
ATOM 2077 C CA  . ASP B 2 113 ? 216.369 235.562 332.011 1.00 106.08 ? 113 ASP B CA  1 
ATOM 2078 C C   . ASP B 2 113 ? 216.292 236.952 332.633 1.00 104.60 ? 113 ASP B C   1 
ATOM 2079 O O   . ASP B 2 113 ? 217.221 237.393 333.308 1.00 104.54 ? 113 ASP B O   1 
ATOM 2080 C CB  . ASP B 2 113 ? 216.789 235.670 330.543 1.00 105.32 ? 113 ASP B CB  1 
ATOM 2081 C CG  . ASP B 2 113 ? 216.995 234.315 329.893 1.00 107.19 ? 113 ASP B CG  1 
ATOM 2082 O OD1 . ASP B 2 113 ? 217.298 233.344 330.618 1.00 106.23 ? 113 ASP B OD1 1 
ATOM 2083 O OD2 . ASP B 2 113 ? 216.856 234.222 328.655 1.00 106.84 ? 113 ASP B OD2 1 
ATOM 2084 N N   . PRO B 2 125 ? 212.781 224.564 342.127 1.00 86.01  ? 125 PRO B N   1 
ATOM 2085 C CA  . PRO B 2 125 ? 212.007 223.778 341.163 1.00 85.88  ? 125 PRO B CA  1 
ATOM 2086 C C   . PRO B 2 125 ? 211.810 222.337 341.622 1.00 88.08  ? 125 PRO B C   1 
ATOM 2087 O O   . PRO B 2 125 ? 211.907 221.407 340.823 1.00 88.63  ? 125 PRO B O   1 
ATOM 2088 C CB  . PRO B 2 125 ? 212.863 223.847 339.896 1.00 87.88  ? 125 PRO B CB  1 
ATOM 2089 C CG  . PRO B 2 125 ? 214.255 223.991 340.402 1.00 89.09  ? 125 PRO B CG  1 
ATOM 2090 C CD  . PRO B 2 125 ? 214.160 224.804 341.664 1.00 86.65  ? 125 PRO B CD  1 
ATOM 2091 N N   . GLU B 2 126 ? 211.524 222.165 342.910 1.00 89.68  ? 126 GLU B N   1 
ATOM 2092 C CA  . GLU B 2 126 ? 211.413 220.836 343.487 1.00 88.99  ? 126 GLU B CA  1 
ATOM 2093 C C   . GLU B 2 126 ? 210.192 220.109 342.927 1.00 86.10  ? 126 GLU B C   1 
ATOM 2094 O O   . GLU B 2 126 ? 209.267 220.711 342.374 1.00 82.48  ? 126 GLU B O   1 
ATOM 2095 C CB  . GLU B 2 126 ? 211.328 220.922 345.010 1.00 84.73  ? 126 GLU B CB  1 
ATOM 2096 C CG  . GLU B 2 126 ? 212.341 220.052 345.741 1.00 84.73  ? 126 GLU B CG  1 
ATOM 2097 C CD  . GLU B 2 126 ? 211.989 218.580 345.700 1.00 86.00  ? 126 GLU B CD  1 
ATOM 2098 O OE1 . GLU B 2 126 ? 210.782 218.259 345.703 1.00 88.64  ? 126 GLU B OE1 1 
ATOM 2099 O OE2 . GLU B 2 126 ? 212.916 217.745 345.665 1.00 83.51  ? 126 GLU B OE2 1 
ATOM 2100 N N   . VAL B 2 127 ? 210.207 218.787 343.072 1.00 89.89  ? 127 VAL B N   1 
ATOM 2101 C CA  . VAL B 2 127 ? 209.130 217.931 342.602 1.00 90.77  ? 127 VAL B CA  1 
ATOM 2102 C C   . VAL B 2 127 ? 208.247 217.460 343.750 1.00 91.08  ? 127 VAL B C   1 
ATOM 2103 O O   . VAL B 2 127 ? 207.025 217.383 343.604 1.00 86.87  ? 127 VAL B O   1 
ATOM 2104 C CB  . VAL B 2 127 ? 209.698 216.729 341.817 1.00 92.17  ? 127 VAL B CB  1 
ATOM 2105 C CG1 . VAL B 2 127 ? 210.478 217.211 340.602 1.00 88.36  ? 127 VAL B CG1 1 
ATOM 2106 C CG2 . VAL B 2 127 ? 210.574 215.860 342.714 1.00 89.20  ? 127 VAL B CG2 1 
ATOM 2107 N N   . ALA B 2 128 ? 208.844 217.139 344.900 1.00 86.81  ? 128 ALA B N   1 
ATOM 2108 C CA  . ALA B 2 128 ? 208.053 216.706 346.045 1.00 84.60  ? 128 ALA B CA  1 
ATOM 2109 C C   . ALA B 2 128 ? 207.133 217.817 346.530 1.00 85.13  ? 128 ALA B C   1 
ATOM 2110 O O   . ALA B 2 128 ? 205.983 217.558 346.899 1.00 85.82  ? 128 ALA B O   1 
ATOM 2111 C CB  . ALA B 2 128 ? 208.970 216.243 347.173 1.00 80.60  ? 128 ALA B CB  1 
ATOM 2112 N N   . ALA B 2 129 ? 207.615 219.058 346.532 1.00 75.78  ? 129 ALA B N   1 
ATOM 2113 C CA  . ALA B 2 129 ? 206.804 220.186 346.973 1.00 74.82  ? 129 ALA B CA  1 
ATOM 2114 C C   . ALA B 2 129 ? 205.658 220.498 346.022 1.00 74.24  ? 129 ALA B C   1 
ATOM 2115 O O   . ALA B 2 129 ? 204.799 221.315 346.370 1.00 73.04  ? 129 ALA B O   1 
ATOM 2116 C CB  . ALA B 2 129 ? 207.683 221.426 347.144 1.00 74.40  ? 129 ALA B CB  1 
ATOM 2117 N N   . CYS B 2 130 ? 205.625 219.886 344.837 1.00 78.74  ? 130 CYS B N   1 
ATOM 2118 C CA  . CYS B 2 130 ? 204.506 220.083 343.924 1.00 80.76  ? 130 CYS B CA  1 
ATOM 2119 C C   . CYS B 2 130 ? 203.203 219.513 344.472 1.00 80.43  ? 130 CYS B C   1 
ATOM 2120 O O   . CYS B 2 130 ? 202.126 219.922 344.027 1.00 77.47  ? 130 CYS B O   1 
ATOM 2121 C CB  . CYS B 2 130 ? 204.822 219.441 342.572 1.00 81.09  ? 130 CYS B CB  1 
ATOM 2122 S SG  . CYS B 2 130 ? 203.459 219.468 341.384 1.00 89.37  ? 130 CYS B SG  1 
ATOM 2123 N N   . ARG B 2 131 ? 203.274 218.593 345.429 1.00 68.31  ? 131 ARG B N   1 
ATOM 2124 C CA  . ARG B 2 131 ? 202.085 217.926 345.931 1.00 64.77  ? 131 ARG B CA  1 
ATOM 2125 C C   . ARG B 2 131 ? 201.154 218.934 346.601 1.00 62.38  ? 131 ARG B C   1 
ATOM 2126 O O   . ARG B 2 131 ? 201.493 220.100 346.804 1.00 66.20  ? 131 ARG B O   1 
ATOM 2127 C CB  . ARG B 2 131 ? 202.478 216.821 346.909 1.00 61.80  ? 131 ARG B CB  1 
ATOM 2128 C CG  . ARG B 2 131 ? 203.178 217.334 348.150 1.00 57.29  ? 131 ARG B CG  1 
ATOM 2129 C CD  . ARG B 2 131 ? 203.703 216.210 349.026 1.00 61.38  ? 131 ARG B CD  1 
ATOM 2130 N NE  . ARG B 2 131 ? 202.718 215.768 350.009 1.00 63.02  ? 131 ARG B NE  1 
ATOM 2131 C CZ  . ARG B 2 131 ? 202.061 214.616 349.972 1.00 64.72  ? 131 ARG B CZ  1 
ATOM 2132 N NH1 . ARG B 2 131 ? 202.248 213.739 348.999 1.00 66.74  ? 131 ARG B NH1 1 
ATOM 2133 N NH2 . ARG B 2 131 ? 201.200 214.331 350.943 1.00 62.15  ? 131 ARG B NH2 1 
ATOM 2134 N N   . PHE B 2 132 ? 199.958 218.469 346.942 1.00 51.30  ? 132 PHE B N   1 
ATOM 2135 C CA  . PHE B 2 132 ? 198.995 219.242 347.707 1.00 47.67  ? 132 PHE B CA  1 
ATOM 2136 C C   . PHE B 2 132 ? 199.164 218.951 349.189 1.00 46.19  ? 132 PHE B C   1 
ATOM 2137 O O   . PHE B 2 132 ? 199.530 217.842 349.582 1.00 56.43  ? 132 PHE B O   1 
ATOM 2138 C CB  . PHE B 2 132 ? 197.565 218.914 347.280 1.00 46.52  ? 132 PHE B CB  1 
ATOM 2139 C CG  . PHE B 2 132 ? 197.213 219.406 345.910 1.00 51.05  ? 132 PHE B CG  1 
ATOM 2140 C CD1 . PHE B 2 132 ? 197.619 218.715 344.786 1.00 52.22  ? 132 PHE B CD1 1 
ATOM 2141 C CD2 . PHE B 2 132 ? 196.467 220.557 345.747 1.00 53.81  ? 132 PHE B CD2 1 
ATOM 2142 C CE1 . PHE B 2 132 ? 197.295 219.168 343.527 1.00 53.72  ? 132 PHE B CE1 1 
ATOM 2143 C CE2 . PHE B 2 132 ? 196.143 221.015 344.492 1.00 52.22  ? 132 PHE B CE2 1 
ATOM 2144 C CZ  . PHE B 2 132 ? 196.556 220.319 343.380 1.00 52.32  ? 132 PHE B CZ  1 
ATOM 2145 N N   . TYR B 2 133 ? 198.896 219.957 350.012 1.00 39.05  ? 133 TYR B N   1 
ATOM 2146 C CA  . TYR B 2 133 ? 199.005 219.840 351.463 1.00 42.18  ? 133 TYR B CA  1 
ATOM 2147 C C   . TYR B 2 133 ? 197.651 220.200 352.060 1.00 40.25  ? 133 TYR B C   1 
ATOM 2148 O O   . TYR B 2 133 ? 197.270 221.371 352.090 1.00 53.23  ? 133 TYR B O   1 
ATOM 2149 C CB  . TYR B 2 133 ? 200.113 220.733 352.002 1.00 47.47  ? 133 TYR B CB  1 
ATOM 2150 C CG  . TYR B 2 133 ? 201.475 220.377 351.468 1.00 46.81  ? 133 TYR B CG  1 
ATOM 2151 C CD1 . TYR B 2 133 ? 201.956 220.949 350.305 1.00 48.43  ? 133 TYR B CD1 1 
ATOM 2152 C CD2 . TYR B 2 133 ? 202.278 219.462 352.123 1.00 54.18  ? 133 TYR B CD2 1 
ATOM 2153 C CE1 . TYR B 2 133 ? 203.195 220.622 349.813 1.00 52.95  ? 133 TYR B CE1 1 
ATOM 2154 C CE2 . TYR B 2 133 ? 203.518 219.130 351.638 1.00 49.50  ? 133 TYR B CE2 1 
ATOM 2155 C CZ  . TYR B 2 133 ? 203.973 219.712 350.484 1.00 52.10  ? 133 TYR B CZ  1 
ATOM 2156 O OH  . TYR B 2 133 ? 205.213 219.381 349.997 1.00 56.92  ? 133 TYR B OH  1 
ATOM 2157 N N   . THR B 2 134 ? 196.929 219.189 352.535 1.00 39.81  ? 134 THR B N   1 
ATOM 2158 C CA  . THR B 2 134 ? 195.580 219.366 353.065 1.00 44.78  ? 134 THR B CA  1 
ATOM 2159 C C   . THR B 2 134 ? 195.672 219.645 354.557 1.00 42.82  ? 134 THR B C   1 
ATOM 2160 O O   . THR B 2 134 ? 195.831 218.742 355.375 1.00 49.16  ? 134 THR B O   1 
ATOM 2161 C CB  . THR B 2 134 ? 194.731 218.136 352.785 1.00 47.88  ? 134 THR B CB  1 
ATOM 2162 O OG1 . THR B 2 134 ? 194.801 217.814 351.392 1.00 48.72  ? 134 THR B OG1 1 
ATOM 2163 C CG2 . THR B 2 134 ? 193.287 218.387 353.160 1.00 44.74  ? 134 THR B CG2 1 
ATOM 2164 N N   . LEU B 2 135 ? 195.555 220.917 354.918 1.00 44.74  ? 135 LEU B N   1 
ATOM 2165 C CA  . LEU B 2 135 ? 195.549 221.291 356.318 1.00 45.44  ? 135 LEU B CA  1 
ATOM 2166 C C   . LEU B 2 135 ? 194.329 220.687 357.009 1.00 54.97  ? 135 LEU B C   1 
ATOM 2167 O O   . LEU B 2 135 ? 193.452 220.097 356.380 1.00 61.75  ? 135 LEU B O   1 
ATOM 2168 C CB  . LEU B 2 135 ? 195.544 222.811 356.465 1.00 45.09  ? 135 LEU B CB  1 
ATOM 2169 C CG  . LEU B 2 135 ? 196.477 223.580 355.526 1.00 48.67  ? 135 LEU B CG  1 
ATOM 2170 C CD1 . LEU B 2 135 ? 196.522 225.045 355.906 1.00 48.58  ? 135 LEU B CD1 1 
ATOM 2171 C CD2 . LEU B 2 135 ? 197.868 222.985 355.526 1.00 53.19  ? 135 LEU B CD2 1 
ATOM 2172 N N   . ASP B 2 136 ? 194.285 220.837 358.328 1.00 57.18  ? 136 ASP B N   1 
ATOM 2173 C CA  . ASP B 2 136 ? 193.137 220.369 359.083 1.00 52.78  ? 136 ASP B CA  1 
ATOM 2174 C C   . ASP B 2 136 ? 191.893 221.168 358.697 1.00 54.04  ? 136 ASP B C   1 
ATOM 2175 O O   . ASP B 2 136 ? 191.962 222.337 358.316 1.00 58.66  ? 136 ASP B O   1 
ATOM 2176 C CB  . ASP B 2 136 ? 193.398 220.503 360.580 1.00 55.43  ? 136 ASP B CB  1 
ATOM 2177 C CG  . ASP B 2 136 ? 193.429 221.951 361.034 1.00 62.74  ? 136 ASP B CG  1 
ATOM 2178 O OD1 . ASP B 2 136 ? 193.797 222.825 360.220 1.00 61.72  ? 136 ASP B OD1 1 
ATOM 2179 O OD2 . ASP B 2 136 ? 193.081 222.219 362.204 1.00 62.44  ? 136 ASP B OD2 1 
ATOM 2180 N N   . THR B 2 137 ? 190.739 220.521 358.799 1.00 45.77  ? 137 THR B N   1 
ATOM 2181 C CA  . THR B 2 137 ? 189.477 221.202 358.570 1.00 40.20  ? 137 THR B CA  1 
ATOM 2182 C C   . THR B 2 137 ? 189.107 222.034 359.790 1.00 41.45  ? 137 THR B C   1 
ATOM 2183 O O   . THR B 2 137 ? 189.633 221.842 360.888 1.00 42.25  ? 137 THR B O   1 
ATOM 2184 C CB  . THR B 2 137 ? 188.358 220.209 358.266 1.00 41.71  ? 137 THR B CB  1 
ATOM 2185 O OG1 . THR B 2 137 ? 188.019 219.486 359.453 1.00 43.60  ? 137 THR B OG1 1 
ATOM 2186 C CG2 . THR B 2 137 ? 188.793 219.237 357.197 1.00 43.82  ? 137 THR B CG2 1 
ATOM 2187 N N   . VAL B 2 138 ? 188.190 222.973 359.583 1.00 42.13  ? 138 VAL B N   1 
ATOM 2188 C CA  . VAL B 2 138 ? 187.719 223.851 360.644 1.00 40.46  ? 138 VAL B CA  1 
ATOM 2189 C C   . VAL B 2 138 ? 186.198 223.836 360.635 1.00 35.86  ? 138 VAL B C   1 
ATOM 2190 O O   . VAL B 2 138 ? 185.568 223.677 359.587 1.00 37.16  ? 138 VAL B O   1 
ATOM 2191 C CB  . VAL B 2 138 ? 188.273 225.282 360.479 1.00 37.03  ? 138 VAL B CB  1 
ATOM 2192 C CG1 . VAL B 2 138 ? 187.742 225.916 359.211 1.00 39.66  ? 138 VAL B CG1 1 
ATOM 2193 C CG2 . VAL B 2 138 ? 187.943 226.119 361.694 1.00 41.35  ? 138 VAL B CG2 1 
ATOM 2194 N N   . SER B 2 139 ? 185.604 223.992 361.812 1.00 33.43  ? 139 SER B N   1 
ATOM 2195 C CA  . SER B 2 139 ? 184.167 223.832 361.984 1.00 37.29  ? 139 SER B CA  1 
ATOM 2196 C C   . SER B 2 139 ? 183.473 225.183 361.880 1.00 36.33  ? 139 SER B C   1 
ATOM 2197 O O   . SER B 2 139 ? 183.689 226.064 362.717 1.00 39.16  ? 139 SER B O   1 
ATOM 2198 C CB  . SER B 2 139 ? 183.851 223.185 363.329 1.00 40.66  ? 139 SER B CB  1 
ATOM 2199 O OG  . SER B 2 139 ? 184.064 224.103 364.383 1.00 51.15  ? 139 SER B OG  1 
ATOM 2200 N N   . TRP B 2 140 ? 182.629 225.331 360.865 1.00 33.70  ? 140 TRP B N   1 
ATOM 2201 C CA  . TRP B 2 140 ? 181.744 226.475 360.705 1.00 33.38  ? 140 TRP B CA  1 
ATOM 2202 C C   . TRP B 2 140 ? 180.482 226.169 361.495 1.00 35.01  ? 140 TRP B C   1 
ATOM 2203 O O   . TRP B 2 140 ? 179.702 225.289 361.122 1.00 43.71  ? 140 TRP B O   1 
ATOM 2204 C CB  . TRP B 2 140 ? 181.439 226.708 359.231 1.00 32.26  ? 140 TRP B CB  1 
ATOM 2205 C CG  . TRP B 2 140 ? 180.530 227.859 358.956 1.00 25.45  ? 140 TRP B CG  1 
ATOM 2206 C CD1 . TRP B 2 140 ? 180.102 228.796 359.841 1.00 31.32  ? 140 TRP B CD1 1 
ATOM 2207 C CD2 . TRP B 2 140 ? 179.939 228.193 357.700 1.00 26.87  ? 140 TRP B CD2 1 
ATOM 2208 N NE1 . TRP B 2 140 ? 179.279 229.697 359.216 1.00 34.52  ? 140 TRP B NE1 1 
ATOM 2209 C CE2 . TRP B 2 140 ? 179.166 229.346 357.898 1.00 31.91  ? 140 TRP B CE2 1 
ATOM 2210 C CE3 . TRP B 2 140 ? 179.990 227.629 356.426 1.00 32.43  ? 140 TRP B CE3 1 
ATOM 2211 C CZ2 . TRP B 2 140 ? 178.447 229.941 356.874 1.00 33.29  ? 140 TRP B CZ2 1 
ATOM 2212 C CZ3 . TRP B 2 140 ? 179.278 228.223 355.413 1.00 30.30  ? 140 TRP B CZ3 1 
ATOM 2213 C CH2 . TRP B 2 140 ? 178.516 229.364 355.641 1.00 33.86  ? 140 TRP B CH2 1 
ATOM 2214 N N   . THR B 2 141 ? 180.305 226.873 362.605 1.00 39.07  ? 141 THR B N   1 
ATOM 2215 C CA  . THR B 2 141 ? 179.114 226.747 363.425 1.00 41.51  ? 141 THR B CA  1 
ATOM 2216 C C   . THR B 2 141 ? 178.207 227.951 363.186 1.00 43.73  ? 141 THR B C   1 
ATOM 2217 O O   . THR B 2 141 ? 178.444 228.772 362.299 1.00 43.43  ? 141 THR B O   1 
ATOM 2218 C CB  . THR B 2 141 ? 179.484 226.632 364.899 1.00 40.09  ? 141 THR B CB  1 
ATOM 2219 O OG1 . THR B 2 141 ? 179.949 227.898 365.372 1.00 49.01  ? 141 THR B OG1 1 
ATOM 2220 C CG2 . THR B 2 141 ? 180.573 225.606 365.094 1.00 37.90  ? 141 THR B CG2 1 
ATOM 2221 N N   . LYS B 2 142 ? 177.154 228.068 363.990 1.00 44.16  ? 142 LYS B N   1 
ATOM 2222 C CA  . LYS B 2 142 ? 176.249 229.204 363.937 1.00 45.08  ? 142 LYS B CA  1 
ATOM 2223 C C   . LYS B 2 142 ? 176.767 230.398 364.732 1.00 51.73  ? 142 LYS B C   1 
ATOM 2224 O O   . LYS B 2 142 ? 175.992 231.309 365.042 1.00 48.37  ? 142 LYS B O   1 
ATOM 2225 C CB  . LYS B 2 142 ? 174.869 228.789 364.448 1.00 41.59  ? 142 LYS B CB  1 
ATOM 2226 C CG  . LYS B 2 142 ? 173.742 229.684 363.976 1.00 47.15  ? 142 LYS B CG  1 
ATOM 2227 C CD  . LYS B 2 142 ? 172.390 229.203 364.473 1.00 44.56  ? 142 LYS B CD  1 
ATOM 2228 C CE  . LYS B 2 142 ? 171.998 227.880 363.849 1.00 45.40  ? 142 LYS B CE  1 
ATOM 2229 N NZ  . LYS B 2 142 ? 170.579 227.549 364.132 1.00 49.59  ? 142 LYS B NZ  1 
ATOM 2230 N N   . GLU B 2 143 ? 178.057 230.408 365.075 1.00 56.92  ? 143 GLU B N   1 
ATOM 2231 C CA  . GLU B 2 143 ? 178.645 231.487 365.855 1.00 51.20  ? 143 GLU B CA  1 
ATOM 2232 C C   . GLU B 2 143 ? 179.990 231.967 365.334 1.00 50.03  ? 143 GLU B C   1 
ATOM 2233 O O   . GLU B 2 143 ? 180.469 233.004 365.799 1.00 53.59  ? 143 GLU B O   1 
ATOM 2234 C CB  . GLU B 2 143 ? 178.823 231.052 367.316 1.00 53.56  ? 143 GLU B CB  1 
ATOM 2235 C CG  . GLU B 2 143 ? 177.534 230.653 368.008 1.00 58.94  ? 143 GLU B CG  1 
ATOM 2236 C CD  . GLU B 2 143 ? 176.614 231.831 368.246 1.00 64.16  ? 143 GLU B CD  1 
ATOM 2237 O OE1 . GLU B 2 143 ? 177.002 232.966 367.901 1.00 59.39  ? 143 GLU B OE1 1 
ATOM 2238 O OE2 . GLU B 2 143 ? 175.506 231.624 368.783 1.00 66.60  ? 143 GLU B OE2 1 
ATOM 2239 N N   . SER B 2 144 ? 180.612 231.261 364.395 1.00 48.73  ? 144 SER B N   1 
ATOM 2240 C CA  . SER B 2 144 ? 181.957 231.614 363.969 1.00 45.70  ? 144 SER B CA  1 
ATOM 2241 C C   . SER B 2 144 ? 181.971 232.980 363.294 1.00 39.64  ? 144 SER B C   1 
ATOM 2242 O O   . SER B 2 144 ? 180.987 233.409 362.689 1.00 43.16  ? 144 SER B O   1 
ATOM 2243 C CB  . SER B 2 144 ? 182.505 230.553 363.017 1.00 45.78  ? 144 SER B CB  1 
ATOM 2244 O OG  . SER B 2 144 ? 181.636 230.355 361.921 1.00 52.46  ? 144 SER B OG  1 
ATOM 2245 N N   . ARG B 2 145 ? 183.110 233.670 363.410 1.00 43.97  ? 145 ARG B N   1 
ATOM 2246 C CA  . ARG B 2 145 ? 183.279 234.996 362.834 1.00 40.48  ? 145 ARG B CA  1 
ATOM 2247 C C   . ARG B 2 145 ? 184.249 235.039 361.666 1.00 43.73  ? 145 ARG B C   1 
ATOM 2248 O O   . ARG B 2 145 ? 184.138 235.944 360.836 1.00 48.79  ? 145 ARG B O   1 
ATOM 2249 C CB  . ARG B 2 145 ? 183.767 235.988 363.898 1.00 46.71  ? 145 ARG B CB  1 
ATOM 2250 C CG  . ARG B 2 145 ? 183.201 235.759 365.283 1.00 51.74  ? 145 ARG B CG  1 
ATOM 2251 C CD  . ARG B 2 145 ? 181.691 235.881 365.311 1.00 50.37  ? 145 ARG B CD  1 
ATOM 2252 N NE  . ARG B 2 145 ? 181.243 237.240 365.038 1.00 49.98  ? 145 ARG B NE  1 
ATOM 2253 C CZ  . ARG B 2 145 ? 179.983 237.643 365.126 1.00 53.08  ? 145 ARG B CZ  1 
ATOM 2254 N NH1 . ARG B 2 145 ? 179.016 236.814 365.484 1.00 48.26  ? 145 ARG B NH1 1 
ATOM 2255 N NH2 . ARG B 2 145 ? 179.687 238.910 364.854 1.00 52.14  ? 145 ARG B NH2 1 
ATOM 2256 N N   . GLY B 2 146 ? 185.189 234.115 361.581 1.00 38.51  ? 146 GLY B N   1 
ATOM 2257 C CA  . GLY B 2 146 ? 186.106 234.081 360.458 1.00 34.96  ? 146 GLY B CA  1 
ATOM 2258 C C   . GLY B 2 146 ? 187.401 233.392 360.825 1.00 38.76  ? 146 GLY B C   1 
ATOM 2259 O O   . GLY B 2 146 ? 187.686 233.118 361.987 1.00 40.11  ? 146 GLY B O   1 
ATOM 2260 N N   . TRP B 2 147 ? 188.198 233.122 359.792 1.00 39.76  ? 147 TRP B N   1 
ATOM 2261 C CA  . TRP B 2 147 ? 189.474 232.438 359.943 1.00 35.77  ? 147 TRP B CA  1 
ATOM 2262 C C   . TRP B 2 147 ? 190.480 233.073 358.993 1.00 44.37  ? 147 TRP B C   1 
ATOM 2263 O O   . TRP B 2 147 ? 190.105 233.680 357.991 1.00 47.15  ? 147 TRP B O   1 
ATOM 2264 C CB  . TRP B 2 147 ? 189.339 230.935 359.657 1.00 35.20  ? 147 TRP B CB  1 
ATOM 2265 C CG  . TRP B 2 147 ? 188.238 230.268 360.429 1.00 43.55  ? 147 TRP B CG  1 
ATOM 2266 C CD1 . TRP B 2 147 ? 188.332 229.700 361.660 1.00 42.59  ? 147 TRP B CD1 1 
ATOM 2267 C CD2 . TRP B 2 147 ? 186.876 230.106 360.017 1.00 46.41  ? 147 TRP B CD2 1 
ATOM 2268 N NE1 . TRP B 2 147 ? 187.116 229.194 362.044 1.00 32.91  ? 147 TRP B NE1 1 
ATOM 2269 C CE2 . TRP B 2 147 ? 186.205 229.432 361.051 1.00 38.09  ? 147 TRP B CE2 1 
ATOM 2270 C CE3 . TRP B 2 147 ? 186.157 230.470 358.874 1.00 40.11  ? 147 TRP B CE3 1 
ATOM 2271 C CZ2 . TRP B 2 147 ? 184.856 229.116 360.978 1.00 39.87  ? 147 TRP B CZ2 1 
ATOM 2272 C CZ3 . TRP B 2 147 ? 184.819 230.153 358.806 1.00 27.09  ? 147 TRP B CZ3 1 
ATOM 2273 C CH2 . TRP B 2 147 ? 184.184 229.485 359.849 1.00 34.19  ? 147 TRP B CH2 1 
ATOM 2274 N N   . TRP B 2 148 ? 191.768 232.944 359.314 1.00 46.42  ? 148 TRP B N   1 
ATOM 2275 C CA  . TRP B 2 148 ? 192.798 233.482 358.433 1.00 46.09  ? 148 TRP B CA  1 
ATOM 2276 C C   . TRP B 2 148 ? 194.101 232.712 358.586 1.00 47.21  ? 148 TRP B C   1 
ATOM 2277 O O   . TRP B 2 148 ? 194.419 232.200 359.661 1.00 47.50  ? 148 TRP B O   1 
ATOM 2278 C CB  . TRP B 2 148 ? 193.041 234.977 358.686 1.00 46.92  ? 148 TRP B CB  1 
ATOM 2279 C CG  . TRP B 2 148 ? 193.352 235.329 360.101 1.00 44.80  ? 148 TRP B CG  1 
ATOM 2280 C CD1 . TRP B 2 148 ? 192.459 235.587 361.093 1.00 47.61  ? 148 TRP B CD1 1 
ATOM 2281 C CD2 . TRP B 2 148 ? 194.650 235.477 360.683 1.00 45.44  ? 148 TRP B CD2 1 
ATOM 2282 N NE1 . TRP B 2 148 ? 193.117 235.883 362.258 1.00 46.74  ? 148 TRP B NE1 1 
ATOM 2283 C CE2 . TRP B 2 148 ? 194.465 235.821 362.032 1.00 47.41  ? 148 TRP B CE2 1 
ATOM 2284 C CE3 . TRP B 2 148 ? 195.952 235.351 360.194 1.00 51.48  ? 148 TRP B CE3 1 
ATOM 2285 C CZ2 . TRP B 2 148 ? 195.530 236.036 362.897 1.00 49.06  ? 148 TRP B CZ2 1 
ATOM 2286 C CZ3 . TRP B 2 148 ? 197.005 235.564 361.056 1.00 50.53  ? 148 TRP B CZ3 1 
ATOM 2287 C CH2 . TRP B 2 148 ? 196.789 235.904 362.390 1.00 48.62  ? 148 TRP B CH2 1 
ATOM 2288 N N   . TRP B 2 149 ? 194.851 232.651 357.486 1.00 43.80  ? 149 TRP B N   1 
ATOM 2289 C CA  . TRP B 2 149 ? 196.150 231.994 357.425 1.00 33.90  ? 149 TRP B CA  1 
ATOM 2290 C C   . TRP B 2 149 ? 197.122 232.885 356.668 1.00 44.76  ? 149 TRP B C   1 
ATOM 2291 O O   . TRP B 2 149 ? 196.723 233.813 355.963 1.00 53.31  ? 149 TRP B O   1 
ATOM 2292 C CB  . TRP B 2 149 ? 196.069 230.623 356.735 1.00 38.09  ? 149 TRP B CB  1 
ATOM 2293 C CG  . TRP B 2 149 ? 195.221 229.633 357.461 1.00 46.13  ? 149 TRP B CG  1 
ATOM 2294 C CD1 . TRP B 2 149 ? 195.627 228.751 358.413 1.00 43.43  ? 149 TRP B CD1 1 
ATOM 2295 C CD2 . TRP B 2 149 ? 193.816 229.426 357.296 1.00 45.91  ? 149 TRP B CD2 1 
ATOM 2296 N NE1 . TRP B 2 149 ? 194.564 228.008 358.854 1.00 43.86  ? 149 TRP B NE1 1 
ATOM 2297 C CE2 . TRP B 2 149 ? 193.439 228.406 358.184 1.00 40.28  ? 149 TRP B CE2 1 
ATOM 2298 C CE3 . TRP B 2 149 ? 192.839 230.009 356.486 1.00 40.73  ? 149 TRP B CE3 1 
ATOM 2299 C CZ2 . TRP B 2 149 ? 192.133 227.955 358.283 1.00 41.14  ? 149 TRP B CZ2 1 
ATOM 2300 C CZ3 . TRP B 2 149 ? 191.547 229.561 356.587 1.00 39.72  ? 149 TRP B CZ3 1 
ATOM 2301 C CH2 . TRP B 2 149 ? 191.203 228.544 357.477 1.00 43.89  ? 149 TRP B CH2 1 
ATOM 2302 N N   . LYS B 2 150 ? 198.411 232.584 356.809 1.00 52.72  ? 150 LYS B N   1 
ATOM 2303 C CA  . LYS B 2 150 ? 199.480 233.330 356.159 1.00 47.59  ? 150 LYS B CA  1 
ATOM 2304 C C   . LYS B 2 150 ? 200.291 232.406 355.264 1.00 43.21  ? 150 LYS B C   1 
ATOM 2305 O O   . LYS B 2 150 ? 200.591 231.271 355.642 1.00 50.06  ? 150 LYS B O   1 
ATOM 2306 C CB  . LYS B 2 150 ? 200.401 233.976 357.191 1.00 50.70  ? 150 LYS B CB  1 
ATOM 2307 C CG  . LYS B 2 150 ? 199.793 235.157 357.912 1.00 55.13  ? 150 LYS B CG  1 
ATOM 2308 C CD  . LYS B 2 150 ? 199.799 236.397 357.038 1.00 55.19  ? 150 LYS B CD  1 
ATOM 2309 C CE  . LYS B 2 150 ? 199.272 237.605 357.784 1.00 55.27  ? 150 LYS B CE  1 
ATOM 2310 N NZ  . LYS B 2 150 ? 200.063 237.908 359.003 1.00 55.50  ? 150 LYS B NZ  1 
ATOM 2311 N N   . LEU B 2 151 ? 200.653 232.895 354.082 1.00 42.60  ? 151 LEU B N   1 
ATOM 2312 C CA  . LEU B 2 151 ? 201.456 232.148 353.137 1.00 45.41  ? 151 LEU B CA  1 
ATOM 2313 C C   . LEU B 2 151 ? 202.761 232.888 352.885 1.00 46.35  ? 151 LEU B C   1 
ATOM 2314 O O   . LEU B 2 151 ? 202.732 234.085 352.552 1.00 46.56  ? 151 LEU B O   1 
ATOM 2315 C CB  . LEU B 2 151 ? 200.713 231.957 351.814 1.00 42.78  ? 151 LEU B CB  1 
ATOM 2316 C CG  . LEU B 2 151 ? 199.523 231.003 351.828 1.00 48.39  ? 151 LEU B CG  1 
ATOM 2317 C CD1 . LEU B 2 151 ? 198.785 231.080 350.507 1.00 47.53  ? 151 LEU B CD1 1 
ATOM 2318 C CD2 . LEU B 2 151 ? 199.982 229.587 352.107 1.00 49.81  ? 151 LEU B CD2 1 
ATOM 2319 N N   . PRO B 2 152 ? 203.921 232.210 352.971 1.00 52.10  ? 152 PRO B N   1 
ATOM 2320 C CA  . PRO B 2 152 ? 204.128 230.760 353.122 1.00 50.54  ? 152 PRO B CA  1 
ATOM 2321 C C   . PRO B 2 152 ? 204.167 230.239 354.556 1.00 49.93  ? 152 PRO B C   1 
ATOM 2322 O O   . PRO B 2 152 ? 204.427 229.062 354.764 1.00 48.58  ? 152 PRO B O   1 
ATOM 2323 C CB  . PRO B 2 152 ? 205.485 230.560 352.450 1.00 41.79  ? 152 PRO B CB  1 
ATOM 2324 C CG  . PRO B 2 152 ? 206.233 231.798 352.812 1.00 48.46  ? 152 PRO B CG  1 
ATOM 2325 C CD  . PRO B 2 152 ? 205.208 232.910 352.821 1.00 56.56  ? 152 PRO B CD  1 
ATOM 2326 N N   . ASP B 2 153 ? 203.906 231.068 355.564 1.00 52.40  ? 153 ASP B N   1 
ATOM 2327 C CA  . ASP B 2 153 ? 204.069 230.620 356.943 1.00 45.53  ? 153 ASP B CA  1 
ATOM 2328 C C   . ASP B 2 153 ? 203.248 229.372 357.231 1.00 52.32  ? 153 ASP B C   1 
ATOM 2329 O O   . ASP B 2 153 ? 203.687 228.493 357.979 1.00 62.34  ? 153 ASP B O   1 
ATOM 2330 C CB  . ASP B 2 153 ? 203.677 231.734 357.906 1.00 50.18  ? 153 ASP B CB  1 
ATOM 2331 C CG  . ASP B 2 153 ? 203.525 231.241 359.322 1.00 52.89  ? 153 ASP B CG  1 
ATOM 2332 O OD1 . ASP B 2 153 ? 204.556 230.969 359.968 1.00 61.89  ? 153 ASP B OD1 1 
ATOM 2333 O OD2 . ASP B 2 153 ? 202.377 231.119 359.790 1.00 56.20  ? 153 ASP B OD2 1 
ATOM 2334 N N   . ALA B 2 154 ? 202.052 229.271 356.652 1.00 59.24  ? 154 ALA B N   1 
ATOM 2335 C CA  . ALA B 2 154 ? 201.182 228.144 356.968 1.00 57.13  ? 154 ALA B CA  1 
ATOM 2336 C C   . ALA B 2 154 ? 201.819 226.809 356.621 1.00 56.03  ? 154 ALA B C   1 
ATOM 2337 O O   . ALA B 2 154 ? 201.428 225.785 357.187 1.00 60.34  ? 154 ALA B O   1 
ATOM 2338 C CB  . ALA B 2 154 ? 199.850 228.285 356.235 1.00 52.27  ? 154 ALA B CB  1 
ATOM 2339 N N   . LEU B 2 155 ? 202.793 226.796 355.711 1.00 56.14  ? 155 LEU B N   1 
ATOM 2340 C CA  . LEU B 2 155 ? 203.448 225.574 355.267 1.00 50.74  ? 155 LEU B CA  1 
ATOM 2341 C C   . LEU B 2 155 ? 204.872 225.461 355.797 1.00 55.18  ? 155 LEU B C   1 
ATOM 2342 O O   . LEU B 2 155 ? 205.747 224.921 355.121 1.00 59.56  ? 155 LEU B O   1 
ATOM 2343 C CB  . LEU B 2 155 ? 203.457 225.504 353.742 1.00 51.71  ? 155 LEU B CB  1 
ATOM 2344 C CG  . LEU B 2 155 ? 202.094 225.536 353.057 1.00 58.19  ? 155 LEU B CG  1 
ATOM 2345 C CD1 . LEU B 2 155 ? 202.265 225.449 351.552 1.00 55.77  ? 155 LEU B CD1 1 
ATOM 2346 C CD2 . LEU B 2 155 ? 201.213 224.412 353.561 1.00 58.36  ? 155 LEU B CD2 1 
ATOM 2347 N N   . ARG B 2 156 ? 205.120 225.958 357.005 1.00 62.00  ? 156 ARG B N   1 
ATOM 2348 C CA  . ARG B 2 156 ? 206.471 225.949 357.546 1.00 58.33  ? 156 ARG B CA  1 
ATOM 2349 C C   . ARG B 2 156 ? 206.856 224.612 358.161 1.00 63.88  ? 156 ARG B C   1 
ATOM 2350 O O   . ARG B 2 156 ? 208.016 224.447 358.551 1.00 68.20  ? 156 ARG B O   1 
ATOM 2351 C CB  . ARG B 2 156 ? 206.633 227.052 358.592 1.00 58.26  ? 156 ARG B CB  1 
ATOM 2352 C CG  . ARG B 2 156 ? 205.749 226.905 359.813 1.00 61.68  ? 156 ARG B CG  1 
ATOM 2353 C CD  . ARG B 2 156 ? 206.445 227.439 361.047 1.00 63.70  ? 156 ARG B CD  1 
ATOM 2354 N NE  . ARG B 2 156 ? 205.537 227.571 362.180 1.00 64.85  ? 156 ARG B NE  1 
ATOM 2355 C CZ  . ARG B 2 156 ? 204.895 228.684 362.508 1.00 65.01  ? 156 ARG B CZ  1 
ATOM 2356 N NH1 . ARG B 2 156 ? 205.036 229.798 361.808 1.00 66.06  ? 156 ARG B NH1 1 
ATOM 2357 N NH2 . ARG B 2 156 ? 204.092 228.680 363.567 1.00 65.14  ? 156 ARG B NH2 1 
ATOM 2358 N N   . ASP B 2 157 ? 205.922 223.661 358.262 1.00 66.41  ? 157 ASP B N   1 
ATOM 2359 C CA  . ASP B 2 157 ? 206.236 222.349 358.814 1.00 63.00  ? 157 ASP B CA  1 
ATOM 2360 C C   . ASP B 2 157 ? 205.688 221.213 357.959 1.00 62.73  ? 157 ASP B C   1 
ATOM 2361 O O   . ASP B 2 157 ? 205.524 220.097 358.464 1.00 63.64  ? 157 ASP B O   1 
ATOM 2362 C CB  . ASP B 2 157 ? 205.684 222.210 360.234 1.00 64.55  ? 157 ASP B CB  1 
ATOM 2363 C CG  . ASP B 2 157 ? 206.274 223.220 361.191 1.00 69.09  ? 157 ASP B CG  1 
ATOM 2364 O OD1 . ASP B 2 157 ? 207.386 223.718 360.921 1.00 71.30  ? 157 ASP B OD1 1 
ATOM 2365 O OD2 . ASP B 2 157 ? 205.630 223.512 362.221 1.00 69.98  ? 157 ASP B OD2 1 
ATOM 2366 N N   . MET B 2 158 ? 205.396 221.456 356.684 1.00 58.71  ? 158 MET B N   1 
ATOM 2367 C CA  . MET B 2 158 ? 204.802 220.448 355.811 1.00 56.40  ? 158 MET B CA  1 
ATOM 2368 C C   . MET B 2 158 ? 205.904 219.856 354.939 1.00 57.56  ? 158 MET B C   1 
ATOM 2369 O O   . MET B 2 158 ? 206.095 220.244 353.787 1.00 58.27  ? 158 MET B O   1 
ATOM 2370 C CB  . MET B 2 158 ? 203.676 221.045 354.968 1.00 54.44  ? 158 MET B CB  1 
ATOM 2371 C CG  . MET B 2 158 ? 202.717 221.922 355.746 1.00 61.56  ? 158 MET B CG  1 
ATOM 2372 S SD  . MET B 2 158 ? 201.922 221.091 357.132 1.00 70.86  ? 158 MET B SD  1 
ATOM 2373 C CE  . MET B 2 158 ? 200.585 220.252 356.295 1.00 57.13  ? 158 MET B CE  1 
ATOM 2374 N N   . GLY B 2 159 ? 206.635 218.904 355.506 1.00 55.32  ? 159 GLY B N   1 
ATOM 2375 C CA  . GLY B 2 159 ? 207.518 218.073 354.708 1.00 54.36  ? 159 GLY B CA  1 
ATOM 2376 C C   . GLY B 2 159 ? 208.606 218.844 353.991 1.00 57.41  ? 159 GLY B C   1 
ATOM 2377 O O   . GLY B 2 159 ? 209.242 219.755 354.538 1.00 59.65  ? 159 GLY B O   1 
ATOM 2378 N N   . LEU B 2 160 ? 208.837 218.459 352.736 1.00 63.88  ? 160 LEU B N   1 
ATOM 2379 C CA  . LEU B 2 160 ? 210.013 218.933 352.021 1.00 64.83  ? 160 LEU B CA  1 
ATOM 2380 C C   . LEU B 2 160 ? 209.900 220.394 351.619 1.00 61.79  ? 160 LEU B C   1 
ATOM 2381 O O   . LEU B 2 160 ? 210.925 221.066 351.487 1.00 71.28  ? 160 LEU B O   1 
ATOM 2382 C CB  . LEU B 2 160 ? 210.270 218.063 350.789 1.00 65.03  ? 160 LEU B CB  1 
ATOM 2383 C CG  . LEU B 2 160 ? 210.621 216.590 351.043 1.00 65.43  ? 160 LEU B CG  1 
ATOM 2384 C CD1 . LEU B 2 160 ? 211.381 216.023 349.861 1.00 65.52  ? 160 LEU B CD1 1 
ATOM 2385 C CD2 . LEU B 2 160 ? 211.423 216.385 352.325 1.00 63.67  ? 160 LEU B CD2 1 
ATOM 2386 N N   . PHE B 2 161 ? 208.690 220.917 351.429 1.00 57.16  ? 161 PHE B N   1 
ATOM 2387 C CA  . PHE B 2 161 ? 208.573 222.348 351.173 1.00 56.25  ? 161 PHE B CA  1 
ATOM 2388 C C   . PHE B 2 161 ? 209.079 223.150 352.364 1.00 54.03  ? 161 PHE B C   1 
ATOM 2389 O O   . PHE B 2 161 ? 209.848 224.101 352.197 1.00 56.33  ? 161 PHE B O   1 
ATOM 2390 C CB  . PHE B 2 161 ? 207.128 222.724 350.850 1.00 57.89  ? 161 PHE B CB  1 
ATOM 2391 C CG  . PHE B 2 161 ? 206.966 224.155 350.430 1.00 61.18  ? 161 PHE B CG  1 
ATOM 2392 C CD1 . PHE B 2 161 ? 207.315 224.557 349.154 1.00 59.84  ? 161 PHE B CD1 1 
ATOM 2393 C CD2 . PHE B 2 161 ? 206.480 225.102 351.313 1.00 60.91  ? 161 PHE B CD2 1 
ATOM 2394 C CE1 . PHE B 2 161 ? 207.177 225.871 348.767 1.00 57.82  ? 161 PHE B CE1 1 
ATOM 2395 C CE2 . PHE B 2 161 ? 206.340 226.419 350.928 1.00 57.23  ? 161 PHE B CE2 1 
ATOM 2396 C CZ  . PHE B 2 161 ? 206.688 226.803 349.654 1.00 54.58  ? 161 PHE B CZ  1 
ATOM 2397 N N   . GLY B 2 162 ? 208.680 222.766 353.577 1.00 57.94  ? 162 GLY B N   1 
ATOM 2398 C CA  . GLY B 2 162 ? 209.207 223.424 354.760 1.00 59.14  ? 162 GLY B CA  1 
ATOM 2399 C C   . GLY B 2 162 ? 210.696 223.210 354.932 1.00 65.36  ? 162 GLY B C   1 
ATOM 2400 O O   . GLY B 2 162 ? 211.422 224.132 355.324 1.00 68.51  ? 162 GLY B O   1 
ATOM 2401 N N   . GLN B 2 163 ? 211.176 221.998 354.641 1.00 64.65  ? 163 GLN B N   1 
ATOM 2402 C CA  . GLN B 2 163 ? 212.612 221.746 354.693 1.00 60.17  ? 163 GLN B CA  1 
ATOM 2403 C C   . GLN B 2 163 ? 213.367 222.718 353.798 1.00 62.11  ? 163 GLN B C   1 
ATOM 2404 O O   . GLN B 2 163 ? 214.327 223.363 354.230 1.00 66.17  ? 163 GLN B O   1 
ATOM 2405 C CB  . GLN B 2 163 ? 212.906 220.307 354.276 1.00 63.07  ? 163 GLN B CB  1 
ATOM 2406 C CG  . GLN B 2 163 ? 212.638 219.281 355.356 1.00 69.23  ? 163 GLN B CG  1 
ATOM 2407 C CD  . GLN B 2 163 ? 213.822 219.082 356.275 1.00 70.74  ? 163 GLN B CD  1 
ATOM 2408 O OE1 . GLN B 2 163 ? 214.968 219.051 355.829 1.00 68.08  ? 163 GLN B OE1 1 
ATOM 2409 N NE2 . GLN B 2 163 ? 213.553 218.947 357.569 1.00 68.80  ? 163 GLN B NE2 1 
ATOM 2410 N N   . ASN B 2 164 ? 212.936 222.846 352.543 1.00 56.91  ? 164 ASN B N   1 
ATOM 2411 C CA  . ASN B 2 164 ? 213.589 223.780 351.636 1.00 56.75  ? 164 ASN B CA  1 
ATOM 2412 C C   . ASN B 2 164 ? 213.468 225.208 352.144 1.00 58.69  ? 164 ASN B C   1 
ATOM 2413 O O   . ASN B 2 164 ? 214.418 225.991 352.051 1.00 64.17  ? 164 ASN B O   1 
ATOM 2414 C CB  . ASN B 2 164 ? 212.989 223.662 350.239 1.00 57.84  ? 164 ASN B CB  1 
ATOM 2415 C CG  . ASN B 2 164 ? 213.265 222.326 349.603 1.00 57.58  ? 164 ASN B CG  1 
ATOM 2416 O OD1 . ASN B 2 164 ? 213.422 221.320 350.291 1.00 61.91  ? 164 ASN B OD1 1 
ATOM 2417 N ND2 . ASN B 2 164 ? 213.336 222.305 348.282 1.00 58.71  ? 164 ASN B ND2 1 
ATOM 2418 N N   . MET B 2 165 ? 212.303 225.566 352.685 1.00 61.81  ? 165 MET B N   1 
ATOM 2419 C CA  . MET B 2 165 ? 212.118 226.911 353.212 1.00 59.44  ? 165 MET B CA  1 
ATOM 2420 C C   . MET B 2 165 ? 213.167 227.240 354.258 1.00 58.03  ? 165 MET B C   1 
ATOM 2421 O O   . MET B 2 165 ? 213.748 228.330 354.244 1.00 63.80  ? 165 MET B O   1 
ATOM 2422 C CB  . MET B 2 165 ? 210.725 227.051 353.823 1.00 59.61  ? 165 MET B CB  1 
ATOM 2423 C CG  . MET B 2 165 ? 209.734 227.816 352.973 1.00 58.90  ? 165 MET B CG  1 
ATOM 2424 S SD  . MET B 2 165 ? 208.102 227.880 353.730 1.00 60.74  ? 165 MET B SD  1 
ATOM 2425 C CE  . MET B 2 165 ? 208.463 228.733 355.261 1.00 55.51  ? 165 MET B CE  1 
ATOM 2426 N N   . TYR B 2 166 ? 213.423 226.314 355.178 1.00 60.44  ? 166 TYR B N   1 
ATOM 2427 C CA  . TYR B 2 166 ? 214.290 226.619 356.308 1.00 63.14  ? 166 TYR B CA  1 
ATOM 2428 C C   . TYR B 2 166 ? 215.775 226.450 356.009 1.00 65.21  ? 166 TYR B C   1 
ATOM 2429 O O   . TYR B 2 166 ? 216.602 226.951 356.777 1.00 67.18  ? 166 TYR B O   1 
ATOM 2430 C CB  . TYR B 2 166 ? 213.918 225.746 357.508 1.00 62.90  ? 166 TYR B CB  1 
ATOM 2431 C CG  . TYR B 2 166 ? 214.670 226.115 358.760 1.00 66.44  ? 166 TYR B CG  1 
ATOM 2432 C CD1 . TYR B 2 166 ? 214.330 227.244 359.486 1.00 65.44  ? 166 TYR B CD1 1 
ATOM 2433 C CD2 . TYR B 2 166 ? 215.726 225.340 359.211 1.00 68.34  ? 166 TYR B CD2 1 
ATOM 2434 C CE1 . TYR B 2 166 ? 215.019 227.589 360.628 1.00 67.31  ? 166 TYR B CE1 1 
ATOM 2435 C CE2 . TYR B 2 166 ? 216.421 225.677 360.352 1.00 68.66  ? 166 TYR B CE2 1 
ATOM 2436 C CZ  . TYR B 2 166 ? 216.063 226.801 361.056 1.00 67.65  ? 166 TYR B CZ  1 
ATOM 2437 O OH  . TYR B 2 166 ? 216.754 227.137 362.194 1.00 66.33  ? 166 TYR B OH  1 
ATOM 2438 N N   . TYR B 2 167 ? 216.141 225.775 354.919 1.00 68.69  ? 167 TYR B N   1 
ATOM 2439 C CA  . TYR B 2 167 ? 217.540 225.514 354.599 1.00 66.99  ? 167 TYR B CA  1 
ATOM 2440 C C   . TYR B 2 167 ? 217.995 226.229 353.334 1.00 63.40  ? 167 TYR B C   1 
ATOM 2441 O O   . TYR B 2 167 ? 218.864 225.723 352.621 1.00 62.30  ? 167 TYR B O   1 
ATOM 2442 C CB  . TYR B 2 167 ? 217.781 224.010 354.466 1.00 66.01  ? 167 TYR B CB  1 
ATOM 2443 C CG  . TYR B 2 167 ? 217.622 223.253 355.762 1.00 70.07  ? 167 TYR B CG  1 
ATOM 2444 C CD1 . TYR B 2 167 ? 218.169 223.736 356.945 1.00 68.01  ? 167 TYR B CD1 1 
ATOM 2445 C CD2 . TYR B 2 167 ? 216.916 222.062 355.806 1.00 70.05  ? 167 TYR B CD2 1 
ATOM 2446 C CE1 . TYR B 2 167 ? 218.021 223.051 358.130 1.00 70.36  ? 167 TYR B CE1 1 
ATOM 2447 C CE2 . TYR B 2 167 ? 216.761 221.369 356.988 1.00 70.29  ? 167 TYR B CE2 1 
ATOM 2448 C CZ  . TYR B 2 167 ? 217.314 221.867 358.147 1.00 72.75  ? 167 TYR B CZ  1 
ATOM 2449 O OH  . TYR B 2 167 ? 217.160 221.173 359.325 1.00 69.13  ? 167 TYR B OH  1 
ATOM 2450 N N   . HIS B 2 168 ? 217.420 227.388 353.038 1.00 59.26  ? 168 HIS B N   1 
ATOM 2451 C CA  . HIS B 2 168 ? 217.866 228.225 351.938 1.00 55.35  ? 168 HIS B CA  1 
ATOM 2452 C C   . HIS B 2 168 ? 217.811 229.680 352.372 1.00 56.88  ? 168 HIS B C   1 
ATOM 2453 O O   . HIS B 2 168 ? 217.103 230.042 353.314 1.00 58.62  ? 168 HIS B O   1 
ATOM 2454 C CB  . HIS B 2 168 ? 217.016 228.031 350.683 1.00 54.49  ? 168 HIS B CB  1 
ATOM 2455 C CG  . HIS B 2 168 ? 217.296 226.758 349.951 1.00 57.19  ? 168 HIS B CG  1 
ATOM 2456 N ND1 . HIS B 2 168 ? 216.633 225.582 350.221 1.00 59.11  ? 168 HIS B ND1 1 
ATOM 2457 C CD2 . HIS B 2 168 ? 218.161 226.480 348.948 1.00 58.90  ? 168 HIS B CD2 1 
ATOM 2458 C CE1 . HIS B 2 168 ? 217.079 224.633 349.419 1.00 56.96  ? 168 HIS B CE1 1 
ATOM 2459 N NE2 . HIS B 2 168 ? 218.008 225.152 348.637 1.00 59.36  ? 168 HIS B NE2 1 
ATOM 2460 N N   . TYR B 2 169 ? 218.580 230.514 351.679 1.00 56.55  ? 169 TYR B N   1 
ATOM 2461 C CA  . TYR B 2 169 ? 218.597 231.937 351.983 1.00 55.99  ? 169 TYR B CA  1 
ATOM 2462 C C   . TYR B 2 169 ? 217.488 232.686 351.256 1.00 53.41  ? 169 TYR B C   1 
ATOM 2463 O O   . TYR B 2 169 ? 216.872 233.585 351.836 1.00 52.76  ? 169 TYR B O   1 
ATOM 2464 C CB  . TYR B 2 169 ? 219.965 232.531 351.633 1.00 55.11  ? 169 TYR B CB  1 
ATOM 2465 C CG  . TYR B 2 169 ? 220.095 233.997 351.977 1.00 58.66  ? 169 TYR B CG  1 
ATOM 2466 C CD1 . TYR B 2 169 ? 219.968 234.436 353.285 1.00 53.07  ? 169 TYR B CD1 1 
ATOM 2467 C CD2 . TYR B 2 169 ? 220.340 234.942 350.992 1.00 56.72  ? 169 TYR B CD2 1 
ATOM 2468 C CE1 . TYR B 2 169 ? 220.078 235.772 353.600 1.00 50.61  ? 169 TYR B CE1 1 
ATOM 2469 C CE2 . TYR B 2 169 ? 220.449 236.277 351.299 1.00 50.17  ? 169 TYR B CE2 1 
ATOM 2470 C CZ  . TYR B 2 169 ? 220.320 236.686 352.602 1.00 52.73  ? 169 TYR B CZ  1 
ATOM 2471 O OH  . TYR B 2 169 ? 220.434 238.020 352.908 1.00 55.30  ? 169 TYR B OH  1 
ATOM 2472 N N   . LEU B 2 170 ? 217.204 232.324 350.006 1.00 52.73  ? 170 LEU B N   1 
ATOM 2473 C CA  . LEU B 2 170 ? 216.188 232.992 349.208 1.00 49.45  ? 170 LEU B CA  1 
ATOM 2474 C C   . LEU B 2 170 ? 215.274 231.958 348.570 1.00 55.02  ? 170 LEU B C   1 
ATOM 2475 O O   . LEU B 2 170 ? 215.696 230.839 348.281 1.00 59.98  ? 170 LEU B O   1 
ATOM 2476 C CB  . LEU B 2 170 ? 216.818 233.852 348.111 1.00 50.76  ? 170 LEU B CB  1 
ATOM 2477 C CG  . LEU B 2 170 ? 217.906 234.826 348.553 1.00 48.74  ? 170 LEU B CG  1 
ATOM 2478 C CD1 . LEU B 2 170 ? 218.506 235.500 347.343 1.00 50.99  ? 170 LEU B CD1 1 
ATOM 2479 C CD2 . LEU B 2 170 ? 217.358 235.854 349.528 1.00 53.27  ? 170 LEU B CD2 1 
ATOM 2480 N N   . GLY B 2 171 ? 214.024 232.347 348.333 1.00 55.84  ? 171 GLY B N   1 
ATOM 2481 C CA  . GLY B 2 171 ? 213.069 231.452 347.708 1.00 52.97  ? 171 GLY B CA  1 
ATOM 2482 C C   . GLY B 2 171 ? 211.862 232.200 347.197 1.00 55.53  ? 171 GLY B C   1 
ATOM 2483 O O   . GLY B 2 171 ? 211.503 233.259 347.718 1.00 57.19  ? 171 GLY B O   1 
ATOM 2484 N N   . ARG B 2 172 ? 211.229 231.638 346.168 1.00 60.45  ? 172 ARG B N   1 
ATOM 2485 C CA  . ARG B 2 172 ? 210.037 232.234 345.578 1.00 54.58  ? 172 ARG B CA  1 
ATOM 2486 C C   . ARG B 2 172 ? 209.118 231.128 345.081 1.00 61.57  ? 172 ARG B C   1 
ATOM 2487 O O   . ARG B 2 172 ? 209.574 230.035 344.733 1.00 66.10  ? 172 ARG B O   1 
ATOM 2488 C CB  . ARG B 2 172 ? 210.388 233.174 344.418 1.00 50.33  ? 172 ARG B CB  1 
ATOM 2489 C CG  . ARG B 2 172 ? 210.341 232.508 343.050 1.00 54.88  ? 172 ARG B CG  1 
ATOM 2490 C CD  . ARG B 2 172 ? 211.062 233.321 341.996 1.00 57.02  ? 172 ARG B CD  1 
ATOM 2491 N NE  . ARG B 2 172 ? 210.520 234.668 341.861 1.00 60.36  ? 172 ARG B NE  1 
ATOM 2492 C CZ  . ARG B 2 172 ? 209.593 235.029 340.985 1.00 57.95  ? 172 ARG B CZ  1 
ATOM 2493 N NH1 . ARG B 2 172 ? 209.054 234.160 340.147 1.00 60.28  ? 172 ARG B NH1 1 
ATOM 2494 N NH2 . ARG B 2 172 ? 209.199 236.297 340.945 1.00 58.70  ? 172 ARG B NH2 1 
ATOM 2495 N N   . SER B 2 173 ? 207.821 231.428 345.034 1.00 57.99  ? 173 SER B N   1 
ATOM 2496 C CA  . SER B 2 173 ? 206.835 230.482 344.526 1.00 57.09  ? 173 SER B CA  1 
ATOM 2497 C C   . SER B 2 173 ? 205.469 231.147 344.476 1.00 55.82  ? 173 SER B C   1 
ATOM 2498 O O   . SER B 2 173 ? 205.197 232.091 345.223 1.00 54.79  ? 173 SER B O   1 
ATOM 2499 C CB  . SER B 2 173 ? 206.764 229.226 345.402 1.00 60.83  ? 173 SER B CB  1 
ATOM 2500 O OG  . SER B 2 173 ? 206.274 229.542 346.690 1.00 64.06  ? 173 SER B OG  1 
ATOM 2501 N N   . GLY B 2 174 ? 204.616 230.645 343.580 1.00 51.21  ? 174 GLY B N   1 
ATOM 2502 C CA  . GLY B 2 174 ? 203.202 230.937 343.608 1.00 46.60  ? 174 GLY B CA  1 
ATOM 2503 C C   . GLY B 2 174 ? 202.444 229.833 344.329 1.00 51.87  ? 174 GLY B C   1 
ATOM 2504 O O   . GLY B 2 174 ? 203.007 228.828 344.747 1.00 59.91  ? 174 GLY B O   1 
ATOM 2505 N N   . TYR B 2 175 ? 201.134 230.022 344.451 1.00 47.94  ? 175 TYR B N   1 
ATOM 2506 C CA  . TYR B 2 175 ? 200.308 229.063 345.169 1.00 41.44  ? 175 TYR B CA  1 
ATOM 2507 C C   . TYR B 2 175 ? 199.017 228.806 344.412 1.00 48.09  ? 175 TYR B C   1 
ATOM 2508 O O   . TYR B 2 175 ? 198.588 229.603 343.578 1.00 60.18  ? 175 TYR B O   1 
ATOM 2509 C CB  . TYR B 2 175 ? 199.983 229.550 346.581 1.00 42.61  ? 175 TYR B CB  1 
ATOM 2510 C CG  . TYR B 2 175 ? 201.194 230.000 347.345 1.00 40.85  ? 175 TYR B CG  1 
ATOM 2511 C CD1 . TYR B 2 175 ? 201.930 229.107 348.102 1.00 43.97  ? 175 TYR B CD1 1 
ATOM 2512 C CD2 . TYR B 2 175 ? 201.609 231.316 347.302 1.00 48.78  ? 175 TYR B CD2 1 
ATOM 2513 C CE1 . TYR B 2 175 ? 203.040 229.514 348.798 1.00 43.34  ? 175 TYR B CE1 1 
ATOM 2514 C CE2 . TYR B 2 175 ? 202.715 231.732 347.992 1.00 51.43  ? 175 TYR B CE2 1 
ATOM 2515 C CZ  . TYR B 2 175 ? 203.427 230.829 348.741 1.00 53.09  ? 175 TYR B CZ  1 
ATOM 2516 O OH  . TYR B 2 175 ? 204.538 231.250 349.427 1.00 56.94  ? 175 TYR B OH  1 
ATOM 2517 N N   . THR B 2 176 ? 198.413 227.660 344.703 1.00 43.56  ? 176 THR B N   1 
ATOM 2518 C CA  . THR B 2 176 ? 197.055 227.350 344.282 1.00 44.49  ? 176 THR B CA  1 
ATOM 2519 C C   . THR B 2 176 ? 196.298 226.878 345.509 1.00 47.47  ? 176 THR B C   1 
ATOM 2520 O O   . THR B 2 176 ? 196.677 225.876 346.124 1.00 57.60  ? 176 THR B O   1 
ATOM 2521 C CB  . THR B 2 176 ? 197.037 226.281 343.191 1.00 47.19  ? 176 THR B CB  1 
ATOM 2522 O OG1 . THR B 2 176 ? 197.752 226.757 342.047 1.00 54.02  ? 176 THR B OG1 1 
ATOM 2523 C CG2 . THR B 2 176 ? 195.615 225.949 342.792 1.00 40.64  ? 176 THR B CG2 1 
ATOM 2524 N N   . VAL B 2 177 ? 195.245 227.602 345.872 1.00 41.97  ? 177 VAL B N   1 
ATOM 2525 C CA  . VAL B 2 177 ? 194.465 227.325 347.069 1.00 39.13  ? 177 VAL B CA  1 
ATOM 2526 C C   . VAL B 2 177 ? 193.098 226.823 346.639 1.00 40.51  ? 177 VAL B C   1 
ATOM 2527 O O   . VAL B 2 177 ? 192.429 227.456 345.815 1.00 47.98  ? 177 VAL B O   1 
ATOM 2528 C CB  . VAL B 2 177 ? 194.335 228.572 347.957 1.00 41.70  ? 177 VAL B CB  1 
ATOM 2529 C CG1 . VAL B 2 177 ? 193.646 228.221 349.260 1.00 41.11  ? 177 VAL B CG1 1 
ATOM 2530 C CG2 . VAL B 2 177 ? 195.696 229.177 348.214 1.00 43.23  ? 177 VAL B CG2 1 
ATOM 2531 N N   . HIS B 2 178 ? 192.690 225.685 347.190 1.00 44.13  ? 178 HIS B N   1 
ATOM 2532 C CA  . HIS B 2 178 ? 191.384 225.098 346.933 1.00 38.09  ? 178 HIS B CA  1 
ATOM 2533 C C   . HIS B 2 178 ? 190.654 224.988 348.261 1.00 36.56  ? 178 HIS B C   1 
ATOM 2534 O O   . HIS B 2 178 ? 191.154 224.353 349.193 1.00 45.01  ? 178 HIS B O   1 
ATOM 2535 C CB  . HIS B 2 178 ? 191.527 223.730 346.268 1.00 40.17  ? 178 HIS B CB  1 
ATOM 2536 C CG  . HIS B 2 178 ? 190.226 223.114 345.865 1.00 46.71  ? 178 HIS B CG  1 
ATOM 2537 N ND1 . HIS B 2 178 ? 189.395 223.677 344.920 1.00 52.91  ? 178 HIS B ND1 1 
ATOM 2538 C CD2 . HIS B 2 178 ? 189.612 221.981 346.277 1.00 45.34  ? 178 HIS B CD2 1 
ATOM 2539 C CE1 . HIS B 2 178 ? 188.324 222.918 344.770 1.00 48.28  ? 178 HIS B CE1 1 
ATOM 2540 N NE2 . HIS B 2 178 ? 188.431 221.884 345.583 1.00 50.81  ? 178 HIS B NE2 1 
ATOM 2541 N N   . VAL B 2 179 ? 189.489 225.620 348.351 1.00 35.75  ? 179 VAL B N   1 
ATOM 2542 C CA  . VAL B 2 179 ? 188.662 225.607 349.551 1.00 40.69  ? 179 VAL B CA  1 
ATOM 2543 C C   . VAL B 2 179 ? 187.407 224.806 349.255 1.00 38.93  ? 179 VAL B C   1 
ATOM 2544 O O   . VAL B 2 179 ? 186.787 224.976 348.200 1.00 39.83  ? 179 VAL B O   1 
ATOM 2545 C CB  . VAL B 2 179 ? 188.291 227.028 350.014 1.00 36.77  ? 179 VAL B CB  1 
ATOM 2546 C CG1 . VAL B 2 179 ? 187.552 226.969 351.335 1.00 36.57  ? 179 VAL B CG1 1 
ATOM 2547 C CG2 . VAL B 2 179 ? 189.521 227.885 350.130 1.00 40.44  ? 179 VAL B CG2 1 
ATOM 2548 N N   . GLN B 2 180 ? 187.037 223.928 350.184 1.00 41.39  ? 180 GLN B N   1 
ATOM 2549 C CA  . GLN B 2 180 ? 185.850 223.107 350.017 1.00 37.34  ? 180 GLN B CA  1 
ATOM 2550 C C   . GLN B 2 180 ? 185.039 223.098 351.298 1.00 42.39  ? 180 GLN B C   1 
ATOM 2551 O O   . GLN B 2 180 ? 185.590 223.185 352.398 1.00 40.75  ? 180 GLN B O   1 
ATOM 2552 C CB  . GLN B 2 180 ? 186.216 221.681 349.624 1.00 40.13  ? 180 GLN B CB  1 
ATOM 2553 C CG  . GLN B 2 180 ? 187.010 221.614 348.346 1.00 47.57  ? 180 GLN B CG  1 
ATOM 2554 C CD  . GLN B 2 180 ? 187.271 220.202 347.898 1.00 51.74  ? 180 GLN B CD  1 
ATOM 2555 O OE1 . GLN B 2 180 ? 188.414 219.816 347.665 1.00 50.76  ? 180 GLN B OE1 1 
ATOM 2556 N NE2 . GLN B 2 180 ? 186.208 219.417 347.767 1.00 52.06  ? 180 GLN B NE2 1 
ATOM 2557 N N   . CYS B 2 181 ? 183.724 223.003 351.141 1.00 50.00  ? 181 CYS B N   1 
ATOM 2558 C CA  . CYS B 2 181 ? 182.786 222.958 352.251 1.00 47.29  ? 181 CYS B CA  1 
ATOM 2559 C C   . CYS B 2 181 ? 181.824 221.805 352.012 1.00 45.03  ? 181 CYS B C   1 
ATOM 2560 O O   . CYS B 2 181 ? 181.241 221.698 350.930 1.00 49.07  ? 181 CYS B O   1 
ATOM 2561 C CB  . CYS B 2 181 ? 182.029 224.282 352.375 1.00 35.57  ? 181 CYS B CB  1 
ATOM 2562 S SG  . CYS B 2 181 ? 180.994 224.419 353.835 1.00 55.84  ? 181 CYS B SG  1 
ATOM 2563 N N   . ASN B 2 182 ? 181.670 220.939 353.008 1.00 40.82  ? 182 ASN B N   1 
ATOM 2564 C CA  . ASN B 2 182 ? 180.786 219.783 352.915 1.00 40.89  ? 182 ASN B CA  1 
ATOM 2565 C C   . ASN B 2 182 ? 179.459 220.148 353.562 1.00 45.81  ? 182 ASN B C   1 
ATOM 2566 O O   . ASN B 2 182 ? 179.374 220.270 354.786 1.00 52.27  ? 182 ASN B O   1 
ATOM 2567 C CB  . ASN B 2 182 ? 181.404 218.563 353.592 1.00 40.04  ? 182 ASN B CB  1 
ATOM 2568 C CG  . ASN B 2 182 ? 182.527 217.955 352.785 1.00 45.46  ? 182 ASN B CG  1 
ATOM 2569 O OD1 . ASN B 2 182 ? 182.296 217.137 351.898 1.00 46.70  ? 182 ASN B OD1 1 
ATOM 2570 N ND2 . ASN B 2 182 ? 183.756 218.345 353.093 1.00 51.69  ? 182 ASN B ND2 1 
ATOM 2571 N N   . ALA B 2 183 ? 178.425 220.321 352.745 1.00 43.68  ? 183 ALA B N   1 
ATOM 2572 C CA  . ALA B 2 183 ? 177.115 220.696 353.248 1.00 42.91  ? 183 ALA B CA  1 
ATOM 2573 C C   . ALA B 2 183 ? 176.035 219.955 352.478 1.00 49.28  ? 183 ALA B C   1 
ATOM 2574 O O   . ALA B 2 183 ? 176.218 219.581 351.317 1.00 49.47  ? 183 ALA B O   1 
ATOM 2575 C CB  . ALA B 2 183 ? 176.881 222.205 353.146 1.00 41.97  ? 183 ALA B CB  1 
ATOM 2576 N N   . SER B 2 184 ? 174.904 219.751 353.144 1.00 45.72  ? 184 SER B N   1 
ATOM 2577 C CA  . SER B 2 184 ? 173.749 219.108 352.548 1.00 41.23  ? 184 SER B CA  1 
ATOM 2578 C C   . SER B 2 184 ? 172.868 220.149 351.864 1.00 47.96  ? 184 SER B C   1 
ATOM 2579 O O   . SER B 2 184 ? 173.159 221.345 351.861 1.00 53.79  ? 184 SER B O   1 
ATOM 2580 C CB  . SER B 2 184 ? 172.970 218.349 353.614 1.00 44.98  ? 184 SER B CB  1 
ATOM 2581 O OG  . SER B 2 184 ? 172.689 219.200 354.708 1.00 48.19  ? 184 SER B OG  1 
ATOM 2582 N N   . LYS B 2 185 ? 171.768 219.687 351.281 1.00 52.24  ? 185 LYS B N   1 
ATOM 2583 C CA  . LYS B 2 185 ? 170.843 220.571 350.588 1.00 50.53  ? 185 LYS B CA  1 
ATOM 2584 C C   . LYS B 2 185 ? 169.918 221.320 351.534 1.00 48.62  ? 185 LYS B C   1 
ATOM 2585 O O   . LYS B 2 185 ? 169.138 222.156 351.072 1.00 55.48  ? 185 LYS B O   1 
ATOM 2586 C CB  . LYS B 2 185 ? 170.011 219.773 349.585 1.00 54.61  ? 185 LYS B CB  1 
ATOM 2587 C CG  . LYS B 2 185 ? 170.766 219.398 348.323 1.00 57.69  ? 185 LYS B CG  1 
ATOM 2588 C CD  . LYS B 2 185 ? 169.892 218.599 347.374 1.00 59.53  ? 185 LYS B CD  1 
ATOM 2589 C CE  . LYS B 2 185 ? 170.453 218.601 345.961 1.00 59.91  ? 185 LYS B CE  1 
ATOM 2590 N NZ  . LYS B 2 185 ? 171.859 218.124 345.907 1.00 61.42  ? 185 LYS B NZ  1 
ATOM 2591 N N   . PHE B 2 186 ? 169.975 221.037 352.833 1.00 42.62  ? 186 PHE B N   1 
ATOM 2592 C CA  . PHE B 2 186 ? 169.147 221.713 353.819 1.00 45.06  ? 186 PHE B CA  1 
ATOM 2593 C C   . PHE B 2 186 ? 169.938 222.697 354.671 1.00 52.71  ? 186 PHE B C   1 
ATOM 2594 O O   . PHE B 2 186 ? 169.423 223.176 355.686 1.00 51.81  ? 186 PHE B O   1 
ATOM 2595 C CB  . PHE B 2 186 ? 168.443 220.682 354.699 1.00 43.93  ? 186 PHE B CB  1 
ATOM 2596 C CG  . PHE B 2 186 ? 167.400 219.889 353.968 1.00 47.16  ? 186 PHE B CG  1 
ATOM 2597 C CD1 . PHE B 2 186 ? 167.743 218.742 353.276 1.00 47.45  ? 186 PHE B CD1 1 
ATOM 2598 C CD2 . PHE B 2 186 ? 166.081 220.299 353.957 1.00 49.02  ? 186 PHE B CD2 1 
ATOM 2599 C CE1 . PHE B 2 186 ? 166.789 218.016 352.595 1.00 48.39  ? 186 PHE B CE1 1 
ATOM 2600 C CE2 . PHE B 2 186 ? 165.124 219.577 353.278 1.00 50.51  ? 186 PHE B CE2 1 
ATOM 2601 C CZ  . PHE B 2 186 ? 165.480 218.433 352.597 1.00 48.90  ? 186 PHE B CZ  1 
ATOM 2602 N N   . HIS B 2 187 ? 171.172 223.006 354.288 1.00 49.26  ? 187 HIS B N   1 
ATOM 2603 C CA  . HIS B 2 187 ? 171.967 224.039 354.931 1.00 35.41  ? 187 HIS B CA  1 
ATOM 2604 C C   . HIS B 2 187 ? 171.982 225.289 354.061 1.00 39.70  ? 187 HIS B C   1 
ATOM 2605 O O   . HIS B 2 187 ? 171.877 225.212 352.836 1.00 46.38  ? 187 HIS B O   1 
ATOM 2606 C CB  . HIS B 2 187 ? 173.400 223.560 355.172 1.00 34.27  ? 187 HIS B CB  1 
ATOM 2607 C CG  . HIS B 2 187 ? 173.528 222.551 356.270 1.00 36.63  ? 187 HIS B CG  1 
ATOM 2608 N ND1 . HIS B 2 187 ? 173.177 221.228 356.113 1.00 46.48  ? 187 HIS B ND1 1 
ATOM 2609 C CD2 . HIS B 2 187 ? 173.972 222.672 357.541 1.00 36.82  ? 187 HIS B CD2 1 
ATOM 2610 C CE1 . HIS B 2 187 ? 173.397 220.579 357.241 1.00 43.85  ? 187 HIS B CE1 1 
ATOM 2611 N NE2 . HIS B 2 187 ? 173.880 221.433 358.124 1.00 42.21  ? 187 HIS B NE2 1 
ATOM 2612 N N   . GLN B 2 188 ? 172.109 226.447 354.706 1.00 45.34  ? 188 GLN B N   1 
ATOM 2613 C CA  . GLN B 2 188 ? 172.148 227.722 354.005 1.00 35.49  ? 188 GLN B CA  1 
ATOM 2614 C C   . GLN B 2 188 ? 173.179 228.633 354.654 1.00 35.66  ? 188 GLN B C   1 
ATOM 2615 O O   . GLN B 2 188 ? 173.437 228.548 355.855 1.00 39.64  ? 188 GLN B O   1 
ATOM 2616 C CB  . GLN B 2 188 ? 170.774 228.395 354.004 1.00 35.17  ? 188 GLN B CB  1 
ATOM 2617 C CG  . GLN B 2 188 ? 170.157 228.524 355.377 1.00 39.96  ? 188 GLN B CG  1 
ATOM 2618 C CD  . GLN B 2 188 ? 168.754 229.081 355.332 1.00 43.06  ? 188 GLN B CD  1 
ATOM 2619 O OE1 . GLN B 2 188 ? 167.780 228.334 355.320 1.00 45.40  ? 188 GLN B OE1 1 
ATOM 2620 N NE2 . GLN B 2 188 ? 168.643 230.401 355.319 1.00 38.58  ? 188 GLN B NE2 1 
ATOM 2621 N N   . GLY B 2 189 ? 173.757 229.505 353.848 1.00 38.41  ? 189 GLY B N   1 
ATOM 2622 C CA  . GLY B 2 189 ? 174.805 230.402 354.298 1.00 35.77  ? 189 GLY B CA  1 
ATOM 2623 C C   . GLY B 2 189 ? 175.698 230.793 353.142 1.00 34.82  ? 189 GLY B C   1 
ATOM 2624 O O   . GLY B 2 189 ? 175.585 230.279 352.034 1.00 42.42  ? 189 GLY B O   1 
ATOM 2625 N N   . ALA B 2 190 ? 176.605 231.726 353.420 1.00 24.72  ? 190 ALA B N   1 
ATOM 2626 C CA  . ALA B 2 190 ? 177.510 232.218 352.392 1.00 24.54  ? 190 ALA B CA  1 
ATOM 2627 C C   . ALA B 2 190 ? 178.853 232.570 353.007 1.00 37.10  ? 190 ALA B C   1 
ATOM 2628 O O   . ALA B 2 190 ? 178.914 233.184 354.073 1.00 44.67  ? 190 ALA B O   1 
ATOM 2629 C CB  . ALA B 2 190 ? 176.930 233.441 351.681 1.00 28.55  ? 190 ALA B CB  1 
ATOM 2630 N N   . LEU B 2 191 ? 179.925 232.201 352.312 1.00 37.62  ? 191 LEU B N   1 
ATOM 2631 C CA  . LEU B 2 191 ? 181.286 232.489 352.735 1.00 28.94  ? 191 LEU B CA  1 
ATOM 2632 C C   . LEU B 2 191 ? 181.992 233.329 351.683 1.00 33.29  ? 191 LEU B C   1 
ATOM 2633 O O   . LEU B 2 191 ? 181.720 233.211 350.487 1.00 38.39  ? 191 LEU B O   1 
ATOM 2634 C CB  . LEU B 2 191 ? 182.087 231.205 352.957 1.00 34.13  ? 191 LEU B CB  1 
ATOM 2635 C CG  . LEU B 2 191 ? 181.866 230.422 354.246 1.00 36.09  ? 191 LEU B CG  1 
ATOM 2636 C CD1 . LEU B 2 191 ? 182.441 229.040 354.083 1.00 39.04  ? 191 LEU B CD1 1 
ATOM 2637 C CD2 . LEU B 2 191 ? 182.506 231.120 355.421 1.00 31.67  ? 191 LEU B CD2 1 
ATOM 2638 N N   . GLY B 2 192 ? 182.913 234.169 352.140 1.00 30.56  ? 192 GLY B N   1 
ATOM 2639 C CA  . GLY B 2 192 ? 183.776 234.912 351.249 1.00 33.34  ? 192 GLY B CA  1 
ATOM 2640 C C   . GLY B 2 192 ? 185.230 234.600 351.520 1.00 30.92  ? 192 GLY B C   1 
ATOM 2641 O O   . GLY B 2 192 ? 185.657 234.567 352.678 1.00 36.77  ? 192 GLY B O   1 
ATOM 2642 N N   . VAL B 2 193 ? 185.993 234.358 350.458 1.00 26.42  ? 193 VAL B N   1 
ATOM 2643 C CA  . VAL B 2 193 ? 187.411 234.035 350.542 1.00 28.67  ? 193 VAL B CA  1 
ATOM 2644 C C   . VAL B 2 193 ? 188.173 235.170 349.876 1.00 38.03  ? 193 VAL B C   1 
ATOM 2645 O O   . VAL B 2 193 ? 187.919 235.485 348.709 1.00 39.59  ? 193 VAL B O   1 
ATOM 2646 C CB  . VAL B 2 193 ? 187.723 232.692 349.866 1.00 32.09  ? 193 VAL B CB  1 
ATOM 2647 C CG1 . VAL B 2 193 ? 189.176 232.306 350.076 1.00 40.59  ? 193 VAL B CG1 1 
ATOM 2648 C CG2 . VAL B 2 193 ? 186.798 231.611 350.386 1.00 34.07  ? 193 VAL B CG2 1 
ATOM 2649 N N   . PHE B 2 194 ? 189.104 235.778 350.610 1.00 43.28  ? 194 PHE B N   1 
ATOM 2650 C CA  . PHE B 2 194 ? 189.874 236.918 350.130 1.00 33.38  ? 194 PHE B CA  1 
ATOM 2651 C C   . PHE B 2 194 ? 191.363 236.623 350.230 1.00 41.77  ? 194 PHE B C   1 
ATOM 2652 O O   . PHE B 2 194 ? 191.827 236.053 351.224 1.00 48.82  ? 194 PHE B O   1 
ATOM 2653 C CB  . PHE B 2 194 ? 189.551 238.182 350.930 1.00 32.88  ? 194 PHE B CB  1 
ATOM 2654 C CG  . PHE B 2 194 ? 188.091 238.512 350.975 1.00 38.26  ? 194 PHE B CG  1 
ATOM 2655 C CD1 . PHE B 2 194 ? 187.434 238.957 349.844 1.00 38.87  ? 194 PHE B CD1 1 
ATOM 2656 C CD2 . PHE B 2 194 ? 187.374 238.380 352.148 1.00 40.36  ? 194 PHE B CD2 1 
ATOM 2657 C CE1 . PHE B 2 194 ? 186.095 239.258 349.881 1.00 38.02  ? 194 PHE B CE1 1 
ATOM 2658 C CE2 . PHE B 2 194 ? 186.032 238.680 352.189 1.00 36.15  ? 194 PHE B CE2 1 
ATOM 2659 C CZ  . PHE B 2 194 ? 185.393 239.120 351.056 1.00 35.73  ? 194 PHE B CZ  1 
ATOM 2660 N N   . ALA B 2 195 ? 192.107 237.032 349.203 1.00 38.78  ? 195 ALA B N   1 
ATOM 2661 C CA  . ALA B 2 195 ? 193.555 236.848 349.123 1.00 44.14  ? 195 ALA B CA  1 
ATOM 2662 C C   . ALA B 2 195 ? 194.218 238.223 349.184 1.00 44.01  ? 195 ALA B C   1 
ATOM 2663 O O   . ALA B 2 195 ? 194.345 238.914 348.173 1.00 47.71  ? 195 ALA B O   1 
ATOM 2664 C CB  . ALA B 2 195 ? 193.933 236.104 347.851 1.00 46.06  ? 195 ALA B CB  1 
ATOM 2665 N N   . VAL B 2 196 ? 194.663 238.603 350.375 1.00 41.77  ? 196 VAL B N   1 
ATOM 2666 C CA  . VAL B 2 196 ? 195.220 239.928 350.624 1.00 37.87  ? 196 VAL B CA  1 
ATOM 2667 C C   . VAL B 2 196 ? 196.728 239.867 350.391 1.00 39.56  ? 196 VAL B C   1 
ATOM 2668 O O   . VAL B 2 196 ? 197.406 239.060 351.042 1.00 54.75  ? 196 VAL B O   1 
ATOM 2669 C CB  . VAL B 2 196 ? 194.915 240.390 352.052 1.00 38.64  ? 196 VAL B CB  1 
ATOM 2670 C CG1 . VAL B 2 196 ? 195.417 241.803 352.269 1.00 47.83  ? 196 VAL B CG1 1 
ATOM 2671 C CG2 . VAL B 2 196 ? 193.433 240.277 352.340 1.00 37.87  ? 196 VAL B CG2 1 
ATOM 2672 N N   . PRO B 2 197 ? 197.290 240.686 349.499 1.00 41.84  ? 197 PRO B N   1 
ATOM 2673 C CA  . PRO B 2 197 ? 198.753 240.765 349.399 1.00 42.90  ? 197 PRO B CA  1 
ATOM 2674 C C   . PRO B 2 197 ? 199.318 241.669 350.485 1.00 43.95  ? 197 PRO B C   1 
ATOM 2675 O O   . PRO B 2 197 ? 198.802 242.761 350.730 1.00 54.60  ? 197 PRO B O   1 
ATOM 2676 C CB  . PRO B 2 197 ? 198.982 241.350 348.003 1.00 38.03  ? 197 PRO B CB  1 
ATOM 2677 C CG  . PRO B 2 197 ? 197.791 242.164 347.759 1.00 42.02  ? 197 PRO B CG  1 
ATOM 2678 C CD  . PRO B 2 197 ? 196.640 241.489 348.451 1.00 48.03  ? 197 PRO B CD  1 
ATOM 2679 N N   . GLU B 2 198 ? 200.381 241.209 351.136 1.00 48.84  ? 198 GLU B N   1 
ATOM 2680 C CA  . GLU B 2 198 ? 200.996 241.926 352.250 1.00 51.25  ? 198 GLU B CA  1 
ATOM 2681 C C   . GLU B 2 198 ? 199.959 242.241 353.324 1.00 52.33  ? 198 GLU B C   1 
ATOM 2682 O O   . GLU B 2 198 ? 199.764 243.386 353.728 1.00 49.36  ? 198 GLU B O   1 
ATOM 2683 C CB  . GLU B 2 198 ? 201.679 243.202 351.762 1.00 47.33  ? 198 GLU B CB  1 
ATOM 2684 C CG  . GLU B 2 198 ? 202.819 242.964 350.790 1.00 53.24  ? 198 GLU B CG  1 
ATOM 2685 C CD  . GLU B 2 198 ? 204.016 242.297 351.439 1.00 58.05  ? 198 GLU B CD  1 
ATOM 2686 O OE1 . GLU B 2 198 ? 204.020 242.148 352.679 1.00 59.84  ? 198 GLU B OE1 1 
ATOM 2687 O OE2 . GLU B 2 198 ? 204.955 241.920 350.708 1.00 61.75  ? 198 GLU B OE2 1 
ATOM 2688 N N   . MET B 2 199 ? 199.303 241.187 353.801 1.00 52.59  ? 199 MET B N   1 
ATOM 2689 C CA  . MET B 2 199 ? 198.178 241.340 354.713 1.00 47.86  ? 199 MET B CA  1 
ATOM 2690 C C   . MET B 2 199 ? 198.637 241.734 356.109 1.00 53.24  ? 199 MET B C   1 
ATOM 2691 O O   . MET B 2 199 ? 198.571 240.929 357.040 1.00 55.48  ? 199 MET B O   1 
ATOM 2692 C CB  . MET B 2 199 ? 197.370 240.044 354.778 1.00 50.84  ? 199 MET B CB  1 
ATOM 2693 C CG  . MET B 2 199 ? 195.989 240.211 355.388 1.00 56.17  ? 199 MET B CG  1 
ATOM 2694 S SD  . MET B 2 199 ? 194.986 238.715 355.332 1.00 58.64  ? 199 MET B SD  1 
ATOM 2695 C CE  . MET B 2 199 ? 195.590 237.845 356.771 1.00 55.21  ? 199 MET B CE  1 
ATOM 2696 N N   . CYS B 2 200 ? 199.095 242.973 356.270 1.00 63.17  ? 200 CYS B N   1 
ATOM 2697 C CA  . CYS B 2 200 ? 199.439 243.482 357.591 1.00 64.65  ? 200 CYS B CA  1 
ATOM 2698 C C   . CYS B 2 200 ? 198.188 243.628 358.447 1.00 68.67  ? 200 CYS B C   1 
ATOM 2699 O O   . CYS B 2 200 ? 197.381 244.535 358.225 1.00 73.49  ? 200 CYS B O   1 
ATOM 2700 C CB  . CYS B 2 200 ? 200.156 244.827 357.480 1.00 65.10  ? 200 CYS B CB  1 
ATOM 2701 S SG  . CYS B 2 200 ? 201.896 244.718 357.051 1.00 77.25  ? 200 CYS B SG  1 
ATOM 2702 N N   . LEU B 2 201 ? 198.018 242.750 359.427 1.00 59.38  ? 201 LEU B N   1 
ATOM 2703 C CA  . LEU B 2 201 ? 196.884 242.806 360.332 1.00 57.57  ? 201 LEU B CA  1 
ATOM 2704 C C   . LEU B 2 201 ? 197.235 243.646 361.553 1.00 60.00  ? 201 LEU B C   1 
ATOM 2705 O O   . LEU B 2 201 ? 198.352 244.143 361.703 1.00 68.51  ? 201 LEU B O   1 
ATOM 2706 C CB  . LEU B 2 201 ? 196.457 241.397 360.750 1.00 65.78  ? 201 LEU B CB  1 
ATOM 2707 C CG  . LEU B 2 201 ? 195.709 240.549 359.721 1.00 67.30  ? 201 LEU B CG  1 
ATOM 2708 C CD1 . LEU B 2 201 ? 195.481 239.162 360.269 1.00 59.67  ? 201 LEU B CD1 1 
ATOM 2709 C CD2 . LEU B 2 201 ? 194.390 241.192 359.340 1.00 67.84  ? 201 LEU B CD2 1 
ATOM 2710 N N   . ALA B 2 202 ? 196.256 243.808 362.435 1.00 73.92  ? 202 ALA B N   1 
ATOM 2711 C CA  . ALA B 2 202 ? 196.437 244.534 363.682 1.00 77.52  ? 202 ALA B CA  1 
ATOM 2712 C C   . ALA B 2 202 ? 195.248 244.233 364.577 1.00 79.76  ? 202 ALA B C   1 
ATOM 2713 O O   . ALA B 2 202 ? 194.126 244.061 364.096 1.00 79.47  ? 202 ALA B O   1 
ATOM 2714 C CB  . ALA B 2 202 ? 196.564 246.043 363.444 1.00 74.94  ? 202 ALA B CB  1 
ATOM 2715 N N   . GLY B 2 203 ? 195.503 244.172 365.879 1.00 87.73  ? 203 GLY B N   1 
ATOM 2716 C CA  . GLY B 2 203 ? 194.462 243.843 366.830 1.00 85.60  ? 203 GLY B CA  1 
ATOM 2717 C C   . GLY B 2 203 ? 193.743 245.067 367.350 1.00 87.54  ? 203 GLY B C   1 
ATOM 2718 O O   . GLY B 2 203 ? 193.101 245.791 366.583 1.00 86.36  ? 203 GLY B O   1 
ATOM 2719 N N   . ASP B 2 204 ? 193.835 245.304 368.661 1.00 108.13 ? 204 ASP B N   1 
ATOM 2720 C CA  . ASP B 2 204 ? 193.251 246.490 369.273 1.00 110.34 ? 204 ASP B CA  1 
ATOM 2721 C C   . ASP B 2 204 ? 194.199 247.102 370.298 1.00 108.97 ? 204 ASP B C   1 
ATOM 2722 O O   . ASP B 2 204 ? 193.754 247.695 371.287 1.00 108.82 ? 204 ASP B O   1 
ATOM 2723 C CB  . ASP B 2 204 ? 191.907 246.166 369.930 1.00 110.44 ? 204 ASP B CB  1 
ATOM 2724 C CG  . ASP B 2 204 ? 192.049 245.261 371.135 1.00 110.02 ? 204 ASP B CG  1 
ATOM 2725 O OD1 . ASP B 2 204 ? 193.055 244.525 371.211 1.00 109.74 ? 204 ASP B OD1 1 
ATOM 2726 O OD2 . ASP B 2 204 ? 191.154 245.284 372.007 1.00 107.40 ? 204 ASP B OD2 1 
ATOM 2727 N N   . SER B 2 205 ? 195.503 246.964 370.081 1.00 106.72 ? 205 SER B N   1 
ATOM 2728 C CA  . SER B 2 205 ? 196.498 247.537 370.978 1.00 106.97 ? 205 SER B CA  1 
ATOM 2729 C C   . SER B 2 205 ? 196.434 249.059 370.951 1.00 106.07 ? 205 SER B C   1 
ATOM 2730 O O   . SER B 2 205 ? 195.595 249.667 371.615 1.00 106.70 ? 205 SER B O   1 
ATOM 2731 C CB  . SER B 2 205 ? 197.901 247.064 370.594 1.00 106.30 ? 205 SER B CB  1 
ATOM 2732 O OG  . SER B 2 205 ? 198.876 247.588 371.479 1.00 104.68 ? 205 SER B OG  1 
ATOM 2733 N N   . THR B 2 212 ? 202.712 244.625 367.309 1.00 80.79  ? 212 THR B N   1 
ATOM 2734 C CA  . THR B 2 212 ? 202.590 243.172 367.327 1.00 83.13  ? 212 THR B CA  1 
ATOM 2735 C C   . THR B 2 212 ? 203.961 242.515 367.404 1.00 81.56  ? 212 THR B C   1 
ATOM 2736 O O   . THR B 2 212 ? 204.983 243.167 367.203 1.00 80.78  ? 212 THR B O   1 
ATOM 2737 C CB  . THR B 2 212 ? 201.860 242.653 366.079 1.00 83.39  ? 212 THR B CB  1 
ATOM 2738 O OG1 . THR B 2 212 ? 202.608 243.000 364.908 1.00 84.03  ? 212 THR B OG1 1 
ATOM 2739 C CG2 . THR B 2 212 ? 200.466 243.252 365.984 1.00 80.69  ? 212 THR B CG2 1 
ATOM 2740 N N   . SER B 2 213 ? 203.976 241.220 367.695 1.00 80.34  ? 213 SER B N   1 
ATOM 2741 C CA  . SER B 2 213 ? 205.196 240.435 367.776 1.00 79.05  ? 213 SER B CA  1 
ATOM 2742 C C   . SER B 2 213 ? 205.207 239.390 366.666 1.00 79.02  ? 213 SER B C   1 
ATOM 2743 O O   . SER B 2 213 ? 204.223 239.192 365.951 1.00 80.93  ? 213 SER B O   1 
ATOM 2744 C CB  . SER B 2 213 ? 205.321 239.775 369.151 1.00 77.50  ? 213 SER B CB  1 
ATOM 2745 O OG  . SER B 2 213 ? 204.241 238.894 369.394 1.00 79.97  ? 213 SER B OG  1 
ATOM 2746 N N   . TYR B 2 214 ? 206.349 238.717 366.523 1.00 77.42  ? 214 TYR B N   1 
ATOM 2747 C CA  . TYR B 2 214 ? 206.462 237.640 365.550 1.00 76.85  ? 214 TYR B CA  1 
ATOM 2748 C C   . TYR B 2 214 ? 205.558 236.466 365.892 1.00 76.30  ? 214 TYR B C   1 
ATOM 2749 O O   . TYR B 2 214 ? 205.206 235.689 365.000 1.00 74.32  ? 214 TYR B O   1 
ATOM 2750 C CB  . TYR B 2 214 ? 207.912 237.170 365.466 1.00 77.81  ? 214 TYR B CB  1 
ATOM 2751 C CG  . TYR B 2 214 ? 208.183 236.185 364.356 1.00 78.00  ? 214 TYR B CG  1 
ATOM 2752 C CD1 . TYR B 2 214 ? 208.449 236.623 363.068 1.00 77.72  ? 214 TYR B CD1 1 
ATOM 2753 C CD2 . TYR B 2 214 ? 208.186 234.820 364.597 1.00 73.16  ? 214 TYR B CD2 1 
ATOM 2754 C CE1 . TYR B 2 214 ? 208.702 235.731 362.052 1.00 78.33  ? 214 TYR B CE1 1 
ATOM 2755 C CE2 . TYR B 2 214 ? 208.439 233.920 363.587 1.00 72.64  ? 214 TYR B CE2 1 
ATOM 2756 C CZ  . TYR B 2 214 ? 208.696 234.380 362.315 1.00 76.56  ? 214 TYR B CZ  1 
ATOM 2757 O OH  . TYR B 2 214 ? 208.948 233.487 361.301 1.00 78.67  ? 214 TYR B OH  1 
ATOM 2758 N N   . GLN B 2 215 ? 205.173 236.325 367.161 1.00 78.92  ? 215 GLN B N   1 
ATOM 2759 C CA  . GLN B 2 215 ? 204.306 235.224 367.560 1.00 78.24  ? 215 GLN B CA  1 
ATOM 2760 C C   . GLN B 2 215 ? 202.873 235.441 367.099 1.00 79.50  ? 215 GLN B C   1 
ATOM 2761 O O   . GLN B 2 215 ? 202.154 234.470 366.840 1.00 78.92  ? 215 GLN B O   1 
ATOM 2762 C CB  . GLN B 2 215 ? 204.352 235.055 369.078 1.00 80.63  ? 215 GLN B CB  1 
ATOM 2763 C CG  . GLN B 2 215 ? 203.521 233.900 369.610 1.00 82.50  ? 215 GLN B CG  1 
ATOM 2764 C CD  . GLN B 2 215 ? 203.460 233.878 371.124 1.00 82.60  ? 215 GLN B CD  1 
ATOM 2765 O OE1 . GLN B 2 215 ? 203.995 234.763 371.791 1.00 83.07  ? 215 GLN B OE1 1 
ATOM 2766 N NE2 . GLN B 2 215 ? 202.801 232.866 371.675 1.00 79.82  ? 215 GLN B NE2 1 
ATOM 2767 N N   . ASN B 2 216 ? 202.436 236.695 367.000 1.00 77.45  ? 216 ASN B N   1 
ATOM 2768 C CA  . ASN B 2 216 ? 201.059 236.975 366.610 1.00 76.53  ? 216 ASN B CA  1 
ATOM 2769 C C   . ASN B 2 216 ? 200.875 236.874 365.102 1.00 71.98  ? 216 ASN B C   1 
ATOM 2770 O O   . ASN B 2 216 ? 199.928 236.242 364.627 1.00 76.39  ? 216 ASN B O   1 
ATOM 2771 C CB  . ASN B 2 216 ? 200.651 238.363 367.103 1.00 74.60  ? 216 ASN B CB  1 
ATOM 2772 C CG  . ASN B 2 216 ? 200.562 238.440 368.611 1.00 76.30  ? 216 ASN B CG  1 
ATOM 2773 O OD1 . ASN B 2 216 ? 200.918 237.496 369.314 1.00 75.48  ? 216 ASN B OD1 1 
ATOM 2774 N ND2 . ASN B 2 216 ? 200.089 239.571 369.119 1.00 76.77  ? 216 ASN B ND2 1 
ATOM 2775 N N   . ALA B 2 217 ? 201.774 237.486 364.334 1.00 63.83  ? 217 ALA B N   1 
ATOM 2776 C CA  . ALA B 2 217 ? 201.623 237.517 362.887 1.00 63.95  ? 217 ALA B CA  1 
ATOM 2777 C C   . ALA B 2 217 ? 201.839 236.160 362.233 1.00 71.82  ? 217 ALA B C   1 
ATOM 2778 O O   . ALA B 2 217 ? 201.519 236.013 361.049 1.00 70.76  ? 217 ALA B O   1 
ATOM 2779 C CB  . ALA B 2 217 ? 202.595 238.531 362.286 1.00 66.50  ? 217 ALA B CB  1 
ATOM 2780 N N   . ASN B 2 218 ? 202.376 235.176 362.954 1.00 69.64  ? 218 ASN B N   1 
ATOM 2781 C CA  . ASN B 2 218 ? 202.668 233.852 362.403 1.00 58.97  ? 218 ASN B CA  1 
ATOM 2782 C C   . ASN B 2 218 ? 202.048 232.790 363.301 1.00 61.60  ? 218 ASN B C   1 
ATOM 2783 O O   . ASN B 2 218 ? 202.726 232.210 364.159 1.00 62.68  ? 218 ASN B O   1 
ATOM 2784 C CB  . ASN B 2 218 ? 204.173 233.634 362.258 1.00 59.99  ? 218 ASN B CB  1 
ATOM 2785 C CG  . ASN B 2 218 ? 204.805 234.602 361.289 1.00 65.38  ? 218 ASN B CG  1 
ATOM 2786 O OD1 . ASN B 2 218 ? 204.418 235.765 361.221 1.00 69.26  ? 218 ASN B OD1 1 
ATOM 2787 N ND2 . ASN B 2 218 ? 205.779 234.128 360.524 1.00 63.98  ? 218 ASN B ND2 1 
ATOM 2788 N N   . PRO B 2 219 ? 200.754 232.507 363.130 1.00 57.66  ? 219 PRO B N   1 
ATOM 2789 C CA  . PRO B 2 219 ? 200.113 231.467 363.942 1.00 56.01  ? 219 PRO B CA  1 
ATOM 2790 C C   . PRO B 2 219 ? 200.329 230.054 363.426 1.00 60.98  ? 219 PRO B C   1 
ATOM 2791 O O   . PRO B 2 219 ? 199.962 229.101 364.125 1.00 64.61  ? 219 PRO B O   1 
ATOM 2792 C CB  . PRO B 2 219 ? 198.635 231.851 363.875 1.00 55.67  ? 219 PRO B CB  1 
ATOM 2793 C CG  . PRO B 2 219 ? 198.495 232.461 362.528 1.00 60.32  ? 219 PRO B CG  1 
ATOM 2794 C CD  . PRO B 2 219 ? 199.788 233.177 362.244 1.00 59.26  ? 219 PRO B CD  1 
ATOM 2795 N N   . GLY B 2 220 ? 200.900 229.886 362.239 1.00 60.05  ? 220 GLY B N   1 
ATOM 2796 C CA  . GLY B 2 220 ? 201.133 228.565 361.692 1.00 57.24  ? 220 GLY B CA  1 
ATOM 2797 C C   . GLY B 2 220 ? 199.920 228.015 360.967 1.00 59.59  ? 220 GLY B C   1 
ATOM 2798 O O   . GLY B 2 220 ? 198.973 228.728 360.631 1.00 64.12  ? 220 GLY B O   1 
ATOM 2799 N N   . GLU B 2 221 ? 199.964 226.705 360.718 1.00 61.16  ? 221 GLU B N   1 
ATOM 2800 C CA  . GLU B 2 221 ? 198.860 226.038 360.037 1.00 62.52  ? 221 GLU B CA  1 
ATOM 2801 C C   . GLU B 2 221 ? 197.577 226.080 360.849 1.00 63.93  ? 221 GLU B C   1 
ATOM 2802 O O   . GLU B 2 221 ? 196.491 225.934 360.281 1.00 65.20  ? 221 GLU B O   1 
ATOM 2803 C CB  . GLU B 2 221 ? 199.227 224.586 359.739 1.00 58.52  ? 221 GLU B CB  1 
ATOM 2804 C CG  . GLU B 2 221 ? 199.430 223.750 360.984 1.00 65.35  ? 221 GLU B CG  1 
ATOM 2805 C CD  . GLU B 2 221 ? 199.964 222.370 360.680 1.00 69.21  ? 221 GLU B CD  1 
ATOM 2806 O OE1 . GLU B 2 221 ? 200.183 222.067 359.488 1.00 69.06  ? 221 GLU B OE1 1 
ATOM 2807 O OE2 . GLU B 2 221 ? 200.167 221.590 361.633 1.00 67.74  ? 221 GLU B OE2 1 
ATOM 2808 N N   . LYS B 2 222 ? 197.675 226.263 362.165 1.00 64.75  ? 222 LYS B N   1 
ATOM 2809 C CA  . LYS B 2 222 ? 196.475 226.387 362.982 1.00 67.29  ? 222 LYS B CA  1 
ATOM 2810 C C   . LYS B 2 222 ? 195.652 227.600 362.574 1.00 66.23  ? 222 LYS B C   1 
ATOM 2811 O O   . LYS B 2 222 ? 194.424 227.590 362.705 1.00 67.08  ? 222 LYS B O   1 
ATOM 2812 C CB  . LYS B 2 222 ? 196.863 226.478 364.456 1.00 65.46  ? 222 LYS B CB  1 
ATOM 2813 C CG  . LYS B 2 222 ? 195.688 226.554 365.415 1.00 66.43  ? 222 LYS B CG  1 
ATOM 2814 C CD  . LYS B 2 222 ? 196.154 226.759 366.849 1.00 69.20  ? 222 LYS B CD  1 
ATOM 2815 C CE  . LYS B 2 222 ? 197.013 225.602 367.336 1.00 70.30  ? 222 LYS B CE  1 
ATOM 2816 N NZ  . LYS B 2 222 ? 197.362 225.726 368.776 1.00 69.85  ? 222 LYS B NZ  1 
ATOM 2817 N N   . GLY B 2 223 ? 196.306 228.651 362.089 1.00 54.86  ? 223 GLY B N   1 
ATOM 2818 C CA  . GLY B 2 223 ? 195.608 229.844 361.674 1.00 53.91  ? 223 GLY B CA  1 
ATOM 2819 C C   . GLY B 2 223 ? 195.120 230.653 362.863 1.00 54.90  ? 223 GLY B C   1 
ATOM 2820 O O   . GLY B 2 223 ? 195.386 230.350 364.025 1.00 55.92  ? 223 GLY B O   1 
ATOM 2821 N N   . GLY B 2 224 ? 194.375 231.712 362.537 1.00 56.24  ? 224 GLY B N   1 
ATOM 2822 C CA  . GLY B 2 224 ? 193.785 232.567 363.541 1.00 55.05  ? 224 GLY B CA  1 
ATOM 2823 C C   . GLY B 2 224 ? 192.323 232.822 363.225 1.00 53.27  ? 224 GLY B C   1 
ATOM 2824 O O   . GLY B 2 224 ? 191.826 232.462 362.157 1.00 59.82  ? 224 GLY B O   1 
ATOM 2825 N N   . THR B 2 225 ? 191.641 233.453 364.176 1.00 48.17  ? 225 THR B N   1 
ATOM 2826 C CA  . THR B 2 225 ? 190.212 233.710 364.071 1.00 55.07  ? 225 THR B CA  1 
ATOM 2827 C C   . THR B 2 225 ? 189.938 235.190 364.290 1.00 60.08  ? 225 THR B C   1 
ATOM 2828 O O   . THR B 2 225 ? 190.433 235.780 365.255 1.00 62.08  ? 225 THR B O   1 
ATOM 2829 C CB  . THR B 2 225 ? 189.426 232.885 365.091 1.00 53.80  ? 225 THR B CB  1 
ATOM 2830 O OG1 . THR B 2 225 ? 189.649 233.407 366.405 1.00 55.99  ? 225 THR B OG1 1 
ATOM 2831 C CG2 . THR B 2 225 ? 189.864 231.434 365.050 1.00 53.90  ? 225 THR B CG2 1 
ATOM 2832 N N   . PHE B 2 226 ? 189.150 235.782 363.396 1.00 58.33  ? 226 PHE B N   1 
ATOM 2833 C CA  . PHE B 2 226 ? 188.662 237.136 363.590 1.00 49.98  ? 226 PHE B CA  1 
ATOM 2834 C C   . PHE B 2 226 ? 187.728 237.178 364.796 1.00 55.39  ? 226 PHE B C   1 
ATOM 2835 O O   . PHE B 2 226 ? 187.447 236.164 365.438 1.00 59.29  ? 226 PHE B O   1 
ATOM 2836 C CB  . PHE B 2 226 ? 187.939 237.623 362.341 1.00 46.58  ? 226 PHE B CB  1 
ATOM 2837 C CG  . PHE B 2 226 ? 188.846 237.924 361.186 1.00 47.08  ? 226 PHE B CG  1 
ATOM 2838 C CD1 . PHE B 2 226 ? 189.559 239.106 361.143 1.00 53.19  ? 226 PHE B CD1 1 
ATOM 2839 C CD2 . PHE B 2 226 ? 188.962 237.044 360.131 1.00 47.05  ? 226 PHE B CD2 1 
ATOM 2840 C CE1 . PHE B 2 226 ? 190.383 239.393 360.078 1.00 53.05  ? 226 PHE B CE1 1 
ATOM 2841 C CE2 . PHE B 2 226 ? 189.784 237.328 359.063 1.00 48.02  ? 226 PHE B CE2 1 
ATOM 2842 C CZ  . PHE B 2 226 ? 190.494 238.503 359.037 1.00 50.13  ? 226 PHE B CZ  1 
ATOM 2843 N N   . THR B 2 227 ? 187.239 238.373 365.113 1.00 62.03  ? 227 THR B N   1 
ATOM 2844 C CA  . THR B 2 227 ? 186.289 238.531 366.204 1.00 62.90  ? 227 THR B CA  1 
ATOM 2845 C C   . THR B 2 227 ? 185.446 239.771 365.959 1.00 64.10  ? 227 THR B C   1 
ATOM 2846 O O   . THR B 2 227 ? 185.820 240.660 365.190 1.00 68.56  ? 227 THR B O   1 
ATOM 2847 C CB  . THR B 2 227 ? 186.992 238.630 367.562 1.00 67.58  ? 227 THR B CB  1 
ATOM 2848 O OG1 . THR B 2 227 ? 186.014 238.786 368.597 1.00 69.69  ? 227 THR B OG1 1 
ATOM 2849 C CG2 . THR B 2 227 ? 187.943 239.810 367.589 1.00 67.39  ? 227 THR B CG2 1 
ATOM 2850 N N   . GLY B 2 228 ? 184.303 239.820 366.626 1.00 63.30  ? 228 GLY B N   1 
ATOM 2851 C CA  . GLY B 2 228 ? 183.394 240.945 366.542 1.00 67.45  ? 228 GLY B CA  1 
ATOM 2852 C C   . GLY B 2 228 ? 183.665 241.983 367.608 1.00 71.96  ? 228 GLY B C   1 
ATOM 2853 O O   . GLY B 2 228 ? 184.789 242.130 368.098 1.00 69.73  ? 228 GLY B O   1 
ATOM 2854 N N   . THR B 2 229 ? 182.620 242.718 367.970 1.00 83.54  ? 229 THR B N   1 
ATOM 2855 C CA  . THR B 2 229 ? 182.724 243.728 369.015 1.00 82.55  ? 229 THR B CA  1 
ATOM 2856 C C   . THR B 2 229 ? 183.175 243.099 370.329 1.00 81.45  ? 229 THR B C   1 
ATOM 2857 O O   . THR B 2 229 ? 182.710 242.024 370.707 1.00 81.26  ? 229 THR B O   1 
ATOM 2858 C CB  . THR B 2 229 ? 181.384 244.451 369.234 1.00 82.51  ? 229 THR B CB  1 
ATOM 2859 O OG1 . THR B 2 229 ? 180.997 245.123 368.029 1.00 81.31  ? 229 THR B OG1 1 
ATOM 2860 C CG2 . THR B 2 229 ? 181.496 245.463 370.364 1.00 81.31  ? 229 THR B CG2 1 
ATOM 2861 N N   . ARG B 2 242 ? 195.607 237.888 373.726 1.00 97.24  ? 242 ARG B N   1 
ATOM 2862 C CA  . ARG B 2 242 ? 195.569 237.284 372.400 1.00 97.55  ? 242 ARG B CA  1 
ATOM 2863 C C   . ARG B 2 242 ? 195.626 238.347 371.310 1.00 96.54  ? 242 ARG B C   1 
ATOM 2864 O O   . ARG B 2 242 ? 195.755 239.538 371.591 1.00 96.30  ? 242 ARG B O   1 
ATOM 2865 C CB  . ARG B 2 242 ? 194.310 236.429 372.226 1.00 96.89  ? 242 ARG B CB  1 
ATOM 2866 C CG  . ARG B 2 242 ? 192.988 237.188 372.350 1.00 96.45  ? 242 ARG B CG  1 
ATOM 2867 C CD  . ARG B 2 242 ? 192.659 237.570 373.785 1.00 96.54  ? 242 ARG B CD  1 
ATOM 2868 N NE  . ARG B 2 242 ? 192.901 236.470 374.711 1.00 98.86  ? 242 ARG B NE  1 
ATOM 2869 C CZ  . ARG B 2 242 ? 192.077 235.447 374.892 1.00 98.83  ? 242 ARG B CZ  1 
ATOM 2870 N NH1 . ARG B 2 242 ? 190.935 235.352 374.228 1.00 97.74  ? 242 ARG B NH1 1 
ATOM 2871 N NH2 . ARG B 2 242 ? 192.407 234.493 375.758 1.00 97.59  ? 242 ARG B NH2 1 
ATOM 2872 N N   . PHE B 2 243 ? 195.530 237.899 370.060 1.00 77.82  ? 243 PHE B N   1 
ATOM 2873 C CA  . PHE B 2 243 ? 195.588 238.773 368.894 1.00 78.20  ? 243 PHE B CA  1 
ATOM 2874 C C   . PHE B 2 243 ? 194.456 238.381 367.957 1.00 80.64  ? 243 PHE B C   1 
ATOM 2875 O O   . PHE B 2 243 ? 194.496 237.310 367.343 1.00 80.77  ? 243 PHE B O   1 
ATOM 2876 C CB  . PHE B 2 243 ? 196.944 238.666 368.202 1.00 78.56  ? 243 PHE B CB  1 
ATOM 2877 C CG  . PHE B 2 243 ? 196.971 239.250 366.823 1.00 78.42  ? 243 PHE B CG  1 
ATOM 2878 C CD1 . PHE B 2 243 ? 197.139 240.605 366.635 1.00 76.41  ? 243 PHE B CD1 1 
ATOM 2879 C CD2 . PHE B 2 243 ? 196.844 238.436 365.714 1.00 79.65  ? 243 PHE B CD2 1 
ATOM 2880 C CE1 . PHE B 2 243 ? 197.170 241.137 365.368 1.00 77.30  ? 243 PHE B CE1 1 
ATOM 2881 C CE2 . PHE B 2 243 ? 196.874 238.963 364.447 1.00 78.23  ? 243 PHE B CE2 1 
ATOM 2882 C CZ  . PHE B 2 243 ? 197.038 240.314 364.272 1.00 76.19  ? 243 PHE B CZ  1 
ATOM 2883 N N   . CYS B 2 244 ? 193.448 239.244 367.850 1.00 83.48  ? 244 CYS B N   1 
ATOM 2884 C CA  . CYS B 2 244 ? 192.251 238.964 367.061 1.00 78.30  ? 244 CYS B CA  1 
ATOM 2885 C C   . CYS B 2 244 ? 191.780 240.257 366.408 1.00 72.99  ? 244 CYS B C   1 
ATOM 2886 O O   . CYS B 2 244 ? 191.124 241.083 367.063 1.00 72.80  ? 244 CYS B O   1 
ATOM 2887 C CB  . CYS B 2 244 ? 191.154 238.360 367.933 1.00 78.49  ? 244 CYS B CB  1 
ATOM 2888 S SG  . CYS B 2 244 ? 190.941 239.197 369.521 1.00 86.12  ? 244 CYS B SG  1 
ATOM 2889 N N   . PRO B 2 245 ? 192.091 240.475 365.132 1.00 65.16  ? 245 PRO B N   1 
ATOM 2890 C CA  . PRO B 2 245 ? 191.597 241.676 364.453 1.00 69.99  ? 245 PRO B CA  1 
ATOM 2891 C C   . PRO B 2 245 ? 190.076 241.736 364.454 1.00 69.98  ? 245 PRO B C   1 
ATOM 2892 O O   . PRO B 2 245 ? 189.383 240.843 364.942 1.00 71.98  ? 245 PRO B O   1 
ATOM 2893 C CB  . PRO B 2 245 ? 192.157 241.545 363.032 1.00 70.52  ? 245 PRO B CB  1 
ATOM 2894 C CG  . PRO B 2 245 ? 192.633 240.145 362.910 1.00 64.23  ? 245 PRO B CG  1 
ATOM 2895 C CD  . PRO B 2 245 ? 193.009 239.708 364.275 1.00 64.79  ? 245 PRO B CD  1 
ATOM 2896 N N   . VAL B 2 246 ? 189.553 242.829 363.905 1.00 65.60  ? 246 VAL B N   1 
ATOM 2897 C CA  . VAL B 2 246 ? 188.117 243.073 363.846 1.00 66.52  ? 246 VAL B CA  1 
ATOM 2898 C C   . VAL B 2 246 ? 187.601 242.641 362.482 1.00 66.60  ? 246 VAL B C   1 
ATOM 2899 O O   . VAL B 2 246 ? 188.168 243.012 361.447 1.00 64.94  ? 246 VAL B O   1 
ATOM 2900 C CB  . VAL B 2 246 ? 187.793 244.550 364.117 1.00 67.20  ? 246 VAL B CB  1 
ATOM 2901 C CG1 . VAL B 2 246 ? 186.310 244.795 363.970 1.00 64.24  ? 246 VAL B CG1 1 
ATOM 2902 C CG2 . VAL B 2 246 ? 188.261 244.942 365.507 1.00 66.87  ? 246 VAL B CG2 1 
ATOM 2903 N N   . ASP B 2 247 ? 186.521 241.857 362.482 1.00 65.78  ? 247 ASP B N   1 
ATOM 2904 C CA  . ASP B 2 247 ? 186.036 241.248 361.246 1.00 63.94  ? 247 ASP B CA  1 
ATOM 2905 C C   . ASP B 2 247 ? 185.547 242.299 360.257 1.00 64.88  ? 247 ASP B C   1 
ATOM 2906 O O   . ASP B 2 247 ? 185.902 242.262 359.074 1.00 61.62  ? 247 ASP B O   1 
ATOM 2907 C CB  . ASP B 2 247 ? 184.923 240.248 361.560 1.00 62.21  ? 247 ASP B CB  1 
ATOM 2908 C CG  . ASP B 2 247 ? 183.873 240.817 362.493 1.00 64.85  ? 247 ASP B CG  1 
ATOM 2909 O OD1 . ASP B 2 247 ? 184.234 241.641 363.356 1.00 68.53  ? 247 ASP B OD1 1 
ATOM 2910 O OD2 . ASP B 2 247 ? 182.691 240.439 362.368 1.00 60.60  ? 247 ASP B OD2 1 
ATOM 2911 N N   . TYR B 2 248 ? 184.725 243.244 360.716 1.00 64.58  ? 248 TYR B N   1 
ATOM 2912 C CA  . TYR B 2 248 ? 184.131 244.196 359.786 1.00 62.00  ? 248 TYR B CA  1 
ATOM 2913 C C   . TYR B 2 248 ? 185.129 245.228 359.285 1.00 62.56  ? 248 TYR B C   1 
ATOM 2914 O O   . TYR B 2 248 ? 184.817 245.947 358.330 1.00 61.84  ? 248 TYR B O   1 
ATOM 2915 C CB  . TYR B 2 248 ? 182.929 244.894 360.428 1.00 63.48  ? 248 TYR B CB  1 
ATOM 2916 C CG  . TYR B 2 248 ? 183.266 246.054 361.331 1.00 65.48  ? 248 TYR B CG  1 
ATOM 2917 C CD1 . TYR B 2 248 ? 183.522 245.859 362.676 1.00 68.09  ? 248 TYR B CD1 1 
ATOM 2918 C CD2 . TYR B 2 248 ? 183.300 247.350 360.842 1.00 65.73  ? 248 TYR B CD2 1 
ATOM 2919 C CE1 . TYR B 2 248 ? 183.818 246.918 363.504 1.00 66.15  ? 248 TYR B CE1 1 
ATOM 2920 C CE2 . TYR B 2 248 ? 183.597 248.414 361.663 1.00 65.23  ? 248 TYR B CE2 1 
ATOM 2921 C CZ  . TYR B 2 248 ? 183.855 248.192 362.993 1.00 65.96  ? 248 TYR B CZ  1 
ATOM 2922 O OH  . TYR B 2 248 ? 184.152 249.250 363.819 1.00 67.66  ? 248 TYR B OH  1 
ATOM 2923 N N   . LEU B 2 249 ? 186.309 245.319 359.895 1.00 65.88  ? 249 LEU B N   1 
ATOM 2924 C CA  . LEU B 2 249 ? 187.385 246.169 359.406 1.00 65.03  ? 249 LEU B CA  1 
ATOM 2925 C C   . LEU B 2 249 ? 188.481 245.380 358.709 1.00 66.55  ? 249 LEU B C   1 
ATOM 2926 O O   . LEU B 2 249 ? 189.431 245.983 358.201 1.00 62.57  ? 249 LEU B O   1 
ATOM 2927 C CB  . LEU B 2 249 ? 187.997 246.970 360.560 1.00 59.16  ? 249 LEU B CB  1 
ATOM 2928 C CG  . LEU B 2 249 ? 187.082 247.988 361.236 1.00 61.49  ? 249 LEU B CG  1 
ATOM 2929 C CD1 . LEU B 2 249 ? 187.775 248.603 362.435 1.00 62.03  ? 249 LEU B CD1 1 
ATOM 2930 C CD2 . LEU B 2 249 ? 186.661 249.060 360.254 1.00 62.57  ? 249 LEU B CD2 1 
ATOM 2931 N N   . LEU B 2 250 ? 188.377 244.054 358.669 1.00 62.33  ? 250 LEU B N   1 
ATOM 2932 C CA  . LEU B 2 250 ? 189.387 243.191 358.066 1.00 59.34  ? 250 LEU B CA  1 
ATOM 2933 C C   . LEU B 2 250 ? 190.722 243.278 358.796 1.00 61.95  ? 250 LEU B C   1 
ATOM 2934 O O   . LEU B 2 250 ? 191.753 242.858 358.265 1.00 58.95  ? 250 LEU B O   1 
ATOM 2935 C CB  . LEU B 2 250 ? 189.574 243.524 356.584 1.00 58.46  ? 250 LEU B CB  1 
ATOM 2936 C CG  . LEU B 2 250 ? 190.154 242.409 355.715 1.00 57.28  ? 250 LEU B CG  1 
ATOM 2937 C CD1 . LEU B 2 250 ? 189.153 241.283 355.566 1.00 55.12  ? 250 LEU B CD1 1 
ATOM 2938 C CD2 . LEU B 2 250 ? 190.561 242.948 354.355 1.00 54.07  ? 250 LEU B CD2 1 
ATOM 2939 N N   . GLY B 2 251 ? 190.725 243.830 360.006 1.00 69.17  ? 251 GLY B N   1 
ATOM 2940 C CA  . GLY B 2 251 ? 191.912 243.875 360.828 1.00 66.36  ? 251 GLY B CA  1 
ATOM 2941 C C   . GLY B 2 251 ? 192.890 244.977 360.498 1.00 68.05  ? 251 GLY B C   1 
ATOM 2942 O O   . GLY B 2 251 ? 193.915 245.089 361.180 1.00 71.36  ? 251 GLY B O   1 
ATOM 2943 N N   . ASN B 2 252 ? 192.611 245.804 359.488 1.00 68.75  ? 252 ASN B N   1 
ATOM 2944 C CA  . ASN B 2 252 ? 193.544 246.841 359.064 1.00 66.42  ? 252 ASN B CA  1 
ATOM 2945 C C   . ASN B 2 252 ? 192.874 248.206 358.949 1.00 72.83  ? 252 ASN B C   1 
ATOM 2946 O O   . ASN B 2 252 ? 193.445 249.119 358.346 1.00 76.98  ? 252 ASN B O   1 
ATOM 2947 C CB  . ASN B 2 252 ? 194.195 246.461 357.734 1.00 63.77  ? 252 ASN B CB  1 
ATOM 2948 C CG  . ASN B 2 252 ? 193.182 246.239 356.639 1.00 69.27  ? 252 ASN B CG  1 
ATOM 2949 O OD1 . ASN B 2 252 ? 191.995 246.063 356.906 1.00 71.61  ? 252 ASN B OD1 1 
ATOM 2950 N ND2 . ASN B 2 252 ? 193.642 246.246 355.396 1.00 71.00  ? 252 ASN B ND2 1 
ATOM 2951 N N   . GLY B 2 253 ? 191.679 248.369 359.514 1.00 66.95  ? 253 GLY B N   1 
ATOM 2952 C CA  . GLY B 2 253 ? 191.025 249.657 359.577 1.00 65.70  ? 253 GLY B CA  1 
ATOM 2953 C C   . GLY B 2 253 ? 190.131 249.996 358.403 1.00 65.72  ? 253 GLY B C   1 
ATOM 2954 O O   . GLY B 2 253 ? 189.460 251.034 358.443 1.00 67.36  ? 253 GLY B O   1 
ATOM 2955 N N   . THR B 2 254 ? 190.091 249.164 357.368 1.00 59.31  ? 254 THR B N   1 
ATOM 2956 C CA  . THR B 2 254 ? 189.279 249.422 356.188 1.00 59.99  ? 254 THR B CA  1 
ATOM 2957 C C   . THR B 2 254 ? 188.008 248.583 356.235 1.00 60.21  ? 254 THR B C   1 
ATOM 2958 O O   . THR B 2 254 ? 188.025 247.440 356.698 1.00 61.86  ? 254 THR B O   1 
ATOM 2959 C CB  . THR B 2 254 ? 190.053 249.107 354.909 1.00 60.43  ? 254 THR B CB  1 
ATOM 2960 O OG1 . THR B 2 254 ? 190.052 247.693 354.682 1.00 58.85  ? 254 THR B OG1 1 
ATOM 2961 C CG2 . THR B 2 254 ? 191.487 249.590 355.016 1.00 57.25  ? 254 THR B CG2 1 
ATOM 2962 N N   . LEU B 2 255 ? 186.913 249.149 355.733 1.00 58.58  ? 255 LEU B N   1 
ATOM 2963 C CA  . LEU B 2 255 ? 185.616 248.497 355.842 1.00 52.01  ? 255 LEU B CA  1 
ATOM 2964 C C   . LEU B 2 255 ? 185.602 247.176 355.088 1.00 54.87  ? 255 LEU B C   1 
ATOM 2965 O O   . LEU B 2 255 ? 186.319 246.986 354.103 1.00 56.14  ? 255 LEU B O   1 
ATOM 2966 C CB  . LEU B 2 255 ? 184.512 249.401 355.302 1.00 52.28  ? 255 LEU B CB  1 
ATOM 2967 C CG  . LEU B 2 255 ? 184.140 250.602 356.167 1.00 55.70  ? 255 LEU B CG  1 
ATOM 2968 C CD1 . LEU B 2 255 ? 183.145 251.475 355.433 1.00 54.94  ? 255 LEU B CD1 1 
ATOM 2969 C CD2 . LEU B 2 255 ? 183.581 250.148 357.499 1.00 54.89  ? 255 LEU B CD2 1 
ATOM 2970 N N   . LEU B 2 256 ? 184.763 246.258 355.568 1.00 51.73  ? 256 LEU B N   1 
ATOM 2971 C CA  . LEU B 2 256 ? 184.680 244.934 354.966 1.00 50.77  ? 256 LEU B CA  1 
ATOM 2972 C C   . LEU B 2 256 ? 184.056 244.988 353.578 1.00 52.26  ? 256 LEU B C   1 
ATOM 2973 O O   . LEU B 2 256 ? 184.445 244.223 352.690 1.00 55.02  ? 256 LEU B O   1 
ATOM 2974 C CB  . LEU B 2 256 ? 183.877 244.007 355.873 1.00 52.13  ? 256 LEU B CB  1 
ATOM 2975 C CG  . LEU B 2 256 ? 183.626 242.599 355.337 1.00 52.41  ? 256 LEU B CG  1 
ATOM 2976 C CD1 . LEU B 2 256 ? 184.934 241.864 355.133 1.00 50.12  ? 256 LEU B CD1 1 
ATOM 2977 C CD2 . LEU B 2 256 ? 182.729 241.841 356.287 1.00 52.33  ? 256 LEU B CD2 1 
ATOM 2978 N N   . GLY B 2 257 ? 183.083 245.874 353.372 1.00 40.22  ? 257 GLY B N   1 
ATOM 2979 C CA  . GLY B 2 257 ? 182.407 245.921 352.087 1.00 39.00  ? 257 GLY B CA  1 
ATOM 2980 C C   . GLY B 2 257 ? 183.357 246.165 350.933 1.00 46.92  ? 257 GLY B C   1 
ATOM 2981 O O   . GLY B 2 257 ? 183.226 245.556 349.870 1.00 42.38  ? 257 GLY B O   1 
ATOM 2982 N N   . ASN B 2 258 ? 184.324 247.063 351.121 1.00 51.43  ? 258 ASN B N   1 
ATOM 2983 C CA  . ASN B 2 258 ? 185.302 247.357 350.082 1.00 45.24  ? 258 ASN B CA  1 
ATOM 2984 C C   . ASN B 2 258 ? 186.280 246.212 349.852 1.00 45.76  ? 258 ASN B C   1 
ATOM 2985 O O   . ASN B 2 258 ? 186.960 246.195 348.819 1.00 45.77  ? 258 ASN B O   1 
ATOM 2986 C CB  . ASN B 2 258 ? 186.069 248.625 350.448 1.00 43.68  ? 258 ASN B CB  1 
ATOM 2987 C CG  . ASN B 2 258 ? 185.163 249.822 350.636 1.00 47.94  ? 258 ASN B CG  1 
ATOM 2988 O OD1 . ASN B 2 258 ? 184.168 249.974 349.935 1.00 54.41  ? 258 ASN B OD1 1 
ATOM 2989 N ND2 . ASN B 2 258 ? 185.502 250.678 351.589 1.00 46.17  ? 258 ASN B ND2 1 
ATOM 2990 N N   . ALA B 2 259 ? 186.337 245.243 350.764 1.00 43.02  ? 259 ALA B N   1 
ATOM 2991 C CA  . ALA B 2 259 ? 187.292 244.144 350.699 1.00 38.74  ? 259 ALA B CA  1 
ATOM 2992 C C   . ALA B 2 259 ? 187.289 243.439 349.350 1.00 32.90  ? 259 ALA B C   1 
ATOM 2993 O O   . ALA B 2 259 ? 188.221 242.695 349.036 1.00 43.03  ? 259 ALA B O   1 
ATOM 2994 C CB  . ALA B 2 259 ? 186.993 243.133 351.804 1.00 37.67  ? 259 ALA B CB  1 
ATOM 2995 N N   . PHE B 2 260 ? 186.258 243.654 348.544 1.00 30.27  ? 260 PHE B N   1 
ATOM 2996 C CA  . PHE B 2 260 ? 186.177 242.973 347.261 1.00 36.98  ? 260 PHE B CA  1 
ATOM 2997 C C   . PHE B 2 260 ? 187.130 243.543 346.224 1.00 41.62  ? 260 PHE B C   1 
ATOM 2998 O O   . PHE B 2 260 ? 187.136 243.051 345.092 1.00 43.63  ? 260 PHE B O   1 
ATOM 2999 C CB  . PHE B 2 260 ? 184.739 243.016 346.752 1.00 29.88  ? 260 PHE B CB  1 
ATOM 3000 C CG  . PHE B 2 260 ? 183.790 242.219 347.591 1.00 31.66  ? 260 PHE B CG  1 
ATOM 3001 C CD1 . PHE B 2 260 ? 183.390 242.678 348.827 1.00 36.03  ? 260 PHE B CD1 1 
ATOM 3002 C CD2 . PHE B 2 260 ? 183.318 241.004 347.155 1.00 33.09  ? 260 PHE B CD2 1 
ATOM 3003 C CE1 . PHE B 2 260 ? 182.529 241.944 349.606 1.00 31.13  ? 260 PHE B CE1 1 
ATOM 3004 C CE2 . PHE B 2 260 ? 182.460 240.268 347.930 1.00 33.17  ? 260 PHE B CE2 1 
ATOM 3005 C CZ  . PHE B 2 260 ? 182.065 240.740 349.157 1.00 30.46  ? 260 PHE B CZ  1 
ATOM 3006 N N   . VAL B 2 261 ? 187.925 244.561 346.564 1.00 42.77  ? 261 VAL B N   1 
ATOM 3007 C CA  . VAL B 2 261 ? 188.999 244.975 345.663 1.00 37.93  ? 261 VAL B CA  1 
ATOM 3008 C C   . VAL B 2 261 ? 190.060 243.885 345.566 1.00 49.28  ? 261 VAL B C   1 
ATOM 3009 O O   . VAL B 2 261 ? 190.650 243.668 344.501 1.00 49.86  ? 261 VAL B O   1 
ATOM 3010 C CB  . VAL B 2 261 ? 189.605 246.315 346.118 1.00 31.28  ? 261 VAL B CB  1 
ATOM 3011 C CG1 . VAL B 2 261 ? 188.592 247.423 345.969 1.00 46.11  ? 261 VAL B CG1 1 
ATOM 3012 C CG2 . VAL B 2 261 ? 190.096 246.234 347.551 1.00 33.63  ? 261 VAL B CG2 1 
ATOM 3013 N N   . PHE B 2 262 ? 190.319 243.186 346.670 1.00 50.01  ? 262 PHE B N   1 
ATOM 3014 C CA  . PHE B 2 262 ? 191.276 242.096 346.679 1.00 31.07  ? 262 PHE B CA  1 
ATOM 3015 C C   . PHE B 2 262 ? 190.762 240.939 345.831 1.00 35.18  ? 262 PHE B C   1 
ATOM 3016 O O   . PHE B 2 262 ? 189.557 240.805 345.621 1.00 51.42  ? 262 PHE B O   1 
ATOM 3017 C CB  . PHE B 2 262 ? 191.510 241.611 348.104 1.00 26.77  ? 262 PHE B CB  1 
ATOM 3018 C CG  . PHE B 2 262 ? 192.099 242.644 349.012 1.00 31.72  ? 262 PHE B CG  1 
ATOM 3019 C CD1 . PHE B 2 262 ? 193.243 243.326 348.656 1.00 31.81  ? 262 PHE B CD1 1 
ATOM 3020 C CD2 . PHE B 2 262 ? 191.510 242.930 350.224 1.00 36.98  ? 262 PHE B CD2 1 
ATOM 3021 C CE1 . PHE B 2 262 ? 193.787 244.268 349.490 1.00 30.42  ? 262 PHE B CE1 1 
ATOM 3022 C CE2 . PHE B 2 262 ? 192.051 243.877 351.062 1.00 40.92  ? 262 PHE B CE2 1 
ATOM 3023 C CZ  . PHE B 2 262 ? 193.192 244.546 350.694 1.00 32.97  ? 262 PHE B CZ  1 
ATOM 3024 N N   . PRO B 2 263 ? 191.653 240.088 345.326 1.00 35.38  ? 263 PRO B N   1 
ATOM 3025 C CA  . PRO B 2 263 ? 191.186 238.848 344.701 1.00 41.51  ? 263 PRO B CA  1 
ATOM 3026 C C   . PRO B 2 263 ? 190.322 238.072 345.680 1.00 43.52  ? 263 PRO B C   1 
ATOM 3027 O O   . PRO B 2 263 ? 190.654 237.939 346.858 1.00 49.97  ? 263 PRO B O   1 
ATOM 3028 C CB  . PRO B 2 263 ? 192.482 238.107 344.365 1.00 37.28  ? 263 PRO B CB  1 
ATOM 3029 C CG  . PRO B 2 263 ? 193.495 239.168 344.248 1.00 39.94  ? 263 PRO B CG  1 
ATOM 3030 C CD  . PRO B 2 263 ? 193.116 240.215 345.246 1.00 42.36  ? 263 PRO B CD  1 
ATOM 3031 N N   . HIS B 2 264 ? 189.196 237.570 345.191 1.00 40.17  ? 264 HIS B N   1 
ATOM 3032 C CA  . HIS B 2 264 ? 188.182 237.044 346.092 1.00 37.46  ? 264 HIS B CA  1 
ATOM 3033 C C   . HIS B 2 264 ? 187.337 236.018 345.359 1.00 36.82  ? 264 HIS B C   1 
ATOM 3034 O O   . HIS B 2 264 ? 187.397 235.884 344.136 1.00 39.75  ? 264 HIS B O   1 
ATOM 3035 C CB  . HIS B 2 264 ? 187.294 238.164 346.641 1.00 35.45  ? 264 HIS B CB  1 
ATOM 3036 C CG  . HIS B 2 264 ? 186.297 238.674 345.651 1.00 42.91  ? 264 HIS B CG  1 
ATOM 3037 N ND1 . HIS B 2 264 ? 186.652 239.446 344.568 1.00 40.23  ? 264 HIS B ND1 1 
ATOM 3038 C CD2 . HIS B 2 264 ? 184.956 238.508 345.571 1.00 42.85  ? 264 HIS B CD2 1 
ATOM 3039 C CE1 . HIS B 2 264 ? 185.573 239.736 343.865 1.00 39.38  ? 264 HIS B CE1 1 
ATOM 3040 N NE2 . HIS B 2 264 ? 184.531 239.178 344.452 1.00 38.52  ? 264 HIS B NE2 1 
ATOM 3041 N N   . GLN B 2 265 ? 186.559 235.279 346.141 1.00 42.07  ? 265 GLN B N   1 
ATOM 3042 C CA  . GLN B 2 265 ? 185.536 234.400 345.600 1.00 33.75  ? 265 GLN B CA  1 
ATOM 3043 C C   . GLN B 2 265 ? 184.458 234.204 346.655 1.00 35.77  ? 265 GLN B C   1 
ATOM 3044 O O   . GLN B 2 265 ? 184.685 234.411 347.850 1.00 31.46  ? 265 GLN B O   1 
ATOM 3045 C CB  . GLN B 2 265 ? 186.123 233.063 345.151 1.00 32.87  ? 265 GLN B CB  1 
ATOM 3046 C CG  . GLN B 2 265 ? 185.166 232.241 344.318 1.00 40.58  ? 265 GLN B CG  1 
ATOM 3047 C CD  . GLN B 2 265 ? 185.857 231.455 343.229 1.00 47.51  ? 265 GLN B CD  1 
ATOM 3048 O OE1 . GLN B 2 265 ? 187.072 231.530 343.066 1.00 45.10  ? 265 GLN B OE1 1 
ATOM 3049 N NE2 . GLN B 2 265 ? 185.081 230.696 342.470 1.00 52.82  ? 265 GLN B NE2 1 
ATOM 3050 N N   . ILE B 2 266 ? 183.272 233.814 346.196 1.00 41.96  ? 266 ILE B N   1 
ATOM 3051 C CA  . ILE B 2 266 ? 182.101 233.663 347.050 1.00 34.67  ? 266 ILE B CA  1 
ATOM 3052 C C   . ILE B 2 266 ? 181.610 232.229 346.950 1.00 40.16  ? 266 ILE B C   1 
ATOM 3053 O O   . ILE B 2 266 ? 181.442 231.701 345.846 1.00 50.20  ? 266 ILE B O   1 
ATOM 3054 C CB  . ILE B 2 266 ? 180.977 234.638 346.660 1.00 34.40  ? 266 ILE B CB  1 
ATOM 3055 C CG1 . ILE B 2 266 ? 181.430 236.085 346.837 1.00 42.60  ? 266 ILE B CG1 1 
ATOM 3056 C CG2 . ILE B 2 266 ? 179.749 234.377 347.504 1.00 40.74  ? 266 ILE B CG2 1 
ATOM 3057 C CD1 . ILE B 2 266 ? 181.478 236.536 348.274 1.00 44.50  ? 266 ILE B CD1 1 
ATOM 3058 N N   . ILE B 2 267 ? 181.379 231.606 348.098 1.00 39.32  ? 267 ILE B N   1 
ATOM 3059 C CA  . ILE B 2 267 ? 180.829 230.261 348.177 1.00 32.04  ? 267 ILE B CA  1 
ATOM 3060 C C   . ILE B 2 267 ? 179.432 230.380 348.763 1.00 41.31  ? 267 ILE B C   1 
ATOM 3061 O O   . ILE B 2 267 ? 179.272 230.628 349.963 1.00 41.00  ? 267 ILE B O   1 
ATOM 3062 C CB  . ILE B 2 267 ? 181.707 229.335 349.024 1.00 28.39  ? 267 ILE B CB  1 
ATOM 3063 C CG1 . ILE B 2 267 ? 183.030 229.067 348.307 1.00 41.02  ? 267 ILE B CG1 1 
ATOM 3064 C CG2 . ILE B 2 267 ? 180.969 228.044 349.318 1.00 37.15  ? 267 ILE B CG2 1 
ATOM 3065 C CD1 . ILE B 2 267 ? 184.070 228.404 349.173 1.00 37.27  ? 267 ILE B CD1 1 
ATOM 3066 N N   . ASN B 2 268 ? 178.423 230.218 347.915 1.00 46.23  ? 268 ASN B N   1 
ATOM 3067 C CA  . ASN B 2 268 ? 177.029 230.229 348.332 1.00 34.82  ? 268 ASN B CA  1 
ATOM 3068 C C   . ASN B 2 268 ? 176.535 228.791 348.350 1.00 42.48  ? 268 ASN B C   1 
ATOM 3069 O O   . ASN B 2 268 ? 176.547 228.115 347.318 1.00 51.18  ? 268 ASN B O   1 
ATOM 3070 C CB  . ASN B 2 268 ? 176.188 231.088 347.391 1.00 39.58  ? 268 ASN B CB  1 
ATOM 3071 C CG  . ASN B 2 268 ? 174.837 231.428 347.967 1.00 47.16  ? 268 ASN B CG  1 
ATOM 3072 O OD1 . ASN B 2 268 ? 174.555 231.140 349.128 1.00 45.93  ? 268 ASN B OD1 1 
ATOM 3073 N ND2 . ASN B 2 268 ? 173.991 232.056 347.160 1.00 44.56  ? 268 ASN B ND2 1 
ATOM 3074 N N   . LEU B 2 269 ? 176.104 228.325 349.521 1.00 42.07  ? 269 LEU B N   1 
ATOM 3075 C CA  . LEU B 2 269 ? 175.830 226.906 349.688 1.00 36.60  ? 269 LEU B CA  1 
ATOM 3076 C C   . LEU B 2 269 ? 174.767 226.400 348.727 1.00 42.21  ? 269 LEU B C   1 
ATOM 3077 O O   . LEU B 2 269 ? 174.759 225.208 348.409 1.00 52.70  ? 269 LEU B O   1 
ATOM 3078 C CB  . LEU B 2 269 ? 175.409 226.623 351.128 1.00 34.01  ? 269 LEU B CB  1 
ATOM 3079 C CG  . LEU B 2 269 ? 176.493 226.794 352.190 1.00 35.73  ? 269 LEU B CG  1 
ATOM 3080 C CD1 . LEU B 2 269 ? 175.989 226.328 353.538 1.00 39.37  ? 269 LEU B CD1 1 
ATOM 3081 C CD2 . LEU B 2 269 ? 177.753 226.042 351.817 1.00 37.83  ? 269 LEU B CD2 1 
ATOM 3082 N N   . ARG B 2 270 ? 173.880 227.265 348.252 1.00 42.62  ? 270 ARG B N   1 
ATOM 3083 C CA  . ARG B 2 270 ? 172.816 226.844 347.355 1.00 41.96  ? 270 ARG B CA  1 
ATOM 3084 C C   . ARG B 2 270 ? 173.220 226.875 345.889 1.00 43.53  ? 270 ARG B C   1 
ATOM 3085 O O   . ARG B 2 270 ? 172.417 226.483 345.039 1.00 52.75  ? 270 ARG B O   1 
ATOM 3086 C CB  . ARG B 2 270 ? 171.579 227.717 347.560 1.00 42.74  ? 270 ARG B CB  1 
ATOM 3087 C CG  . ARG B 2 270 ? 171.777 229.181 347.256 1.00 44.71  ? 270 ARG B CG  1 
ATOM 3088 C CD  . ARG B 2 270 ? 170.444 229.874 347.116 1.00 44.12  ? 270 ARG B CD  1 
ATOM 3089 N NE  . ARG B 2 270 ? 169.771 229.472 345.889 1.00 47.82  ? 270 ARG B NE  1 
ATOM 3090 C CZ  . ARG B 2 270 ? 168.465 229.552 345.686 1.00 48.74  ? 270 ARG B CZ  1 
ATOM 3091 N NH1 . ARG B 2 270 ? 167.645 230.005 346.618 1.00 46.98  ? 270 ARG B NH1 1 
ATOM 3092 N NH2 . ARG B 2 270 ? 167.967 229.154 344.520 1.00 46.50  ? 270 ARG B NH2 1 
ATOM 3093 N N   . THR B 2 271 ? 174.426 227.336 345.569 1.00 40.87  ? 271 THR B N   1 
ATOM 3094 C CA  . THR B 2 271 ? 174.907 227.364 344.193 1.00 40.78  ? 271 THR B CA  1 
ATOM 3095 C C   . THR B 2 271 ? 176.145 226.508 343.996 1.00 46.91  ? 271 THR B C   1 
ATOM 3096 O O   . THR B 2 271 ? 176.168 225.659 343.099 1.00 51.53  ? 271 THR B O   1 
ATOM 3097 C CB  . THR B 2 271 ? 175.204 228.808 343.765 1.00 48.57  ? 271 THR B CB  1 
ATOM 3098 O OG1 . THR B 2 271 ? 174.067 229.633 344.037 1.00 60.31  ? 271 THR B OG1 1 
ATOM 3099 C CG2 . THR B 2 271 ? 175.517 228.874 342.286 1.00 45.72  ? 271 THR B CG2 1 
ATOM 3100 N N   . ASN B 2 272 ? 177.180 226.711 344.807 1.00 50.26  ? 272 ASN B N   1 
ATOM 3101 C CA  . ASN B 2 272 ? 178.388 225.903 344.740 1.00 45.88  ? 272 ASN B CA  1 
ATOM 3102 C C   . ASN B 2 272 ? 179.029 225.887 346.117 1.00 41.32  ? 272 ASN B C   1 
ATOM 3103 O O   . ASN B 2 272 ? 178.741 226.734 346.963 1.00 42.97  ? 272 ASN B O   1 
ATOM 3104 C CB  . ASN B 2 272 ? 179.371 226.438 343.697 1.00 44.60  ? 272 ASN B CB  1 
ATOM 3105 C CG  . ASN B 2 272 ? 179.919 227.798 344.060 1.00 53.22  ? 272 ASN B CG  1 
ATOM 3106 O OD1 . ASN B 2 272 ? 179.280 228.566 344.775 1.00 51.10  ? 272 ASN B OD1 1 
ATOM 3107 N ND2 . ASN B 2 272 ? 181.113 228.104 343.568 1.00 52.96  ? 272 ASN B ND2 1 
ATOM 3108 N N   . ASN B 2 273 ? 179.906 224.906 346.335 1.00 41.24  ? 273 ASN B N   1 
ATOM 3109 C CA  . ASN B 2 273 ? 180.546 224.730 347.633 1.00 49.58  ? 273 ASN B CA  1 
ATOM 3110 C C   . ASN B 2 273 ? 182.057 224.565 347.514 1.00 49.02  ? 273 ASN B C   1 
ATOM 3111 O O   . ASN B 2 273 ? 182.684 224.013 348.421 1.00 47.16  ? 273 ASN B O   1 
ATOM 3112 C CB  . ASN B 2 273 ? 179.941 223.530 348.363 1.00 46.30  ? 273 ASN B CB  1 
ATOM 3113 C CG  . ASN B 2 273 ? 179.979 222.270 347.533 1.00 47.90  ? 273 ASN B CG  1 
ATOM 3114 O OD1 . ASN B 2 273 ? 180.209 222.316 346.326 1.00 46.62  ? 273 ASN B OD1 1 
ATOM 3115 N ND2 . ASN B 2 273 ? 179.745 221.133 348.174 1.00 52.44  ? 273 ASN B ND2 1 
ATOM 3116 N N   . CYS B 2 274 ? 182.655 225.036 346.422 1.00 42.25  ? 274 CYS B N   1 
ATOM 3117 C CA  . CYS B 2 274 ? 184.092 224.953 346.222 1.00 36.63  ? 274 CYS B CA  1 
ATOM 3118 C C   . CYS B 2 274 ? 184.594 226.255 345.619 1.00 43.39  ? 274 CYS B C   1 
ATOM 3119 O O   . CYS B 2 274 ? 183.891 226.906 344.844 1.00 51.51  ? 274 CYS B O   1 
ATOM 3120 C CB  . CYS B 2 274 ? 184.466 223.782 345.310 1.00 46.99  ? 274 CYS B CB  1 
ATOM 3121 S SG  . CYS B 2 274 ? 183.974 222.168 345.948 1.00 61.55  ? 274 CYS B SG  1 
ATOM 3122 N N   . ALA B 2 275 ? 185.818 226.629 345.982 1.00 48.90  ? 275 ALA B N   1 
ATOM 3123 C CA  . ALA B 2 275 ? 186.454 227.827 345.454 1.00 44.91  ? 275 ALA B CA  1 
ATOM 3124 C C   . ALA B 2 275 ? 187.920 227.537 345.177 1.00 45.24  ? 275 ALA B C   1 
ATOM 3125 O O   . ALA B 2 275 ? 188.537 226.708 345.846 1.00 48.04  ? 275 ALA B O   1 
ATOM 3126 C CB  . ALA B 2 275 ? 186.330 229.004 346.423 1.00 38.35  ? 275 ALA B CB  1 
ATOM 3127 N N   . THR B 2 276 ? 188.478 228.227 344.185 1.00 45.30  ? 276 THR B N   1 
ATOM 3128 C CA  . THR B 2 276 ? 189.869 228.026 343.802 1.00 49.76  ? 276 THR B CA  1 
ATOM 3129 C C   . THR B 2 276 ? 190.502 229.361 343.450 1.00 48.74  ? 276 THR B C   1 
ATOM 3130 O O   . THR B 2 276 ? 189.939 230.130 342.668 1.00 47.64  ? 276 THR B O   1 
ATOM 3131 C CB  . THR B 2 276 ? 189.981 227.063 342.616 1.00 48.54  ? 276 THR B CB  1 
ATOM 3132 O OG1 . THR B 2 276 ? 189.393 225.805 342.962 1.00 45.84  ? 276 THR B OG1 1 
ATOM 3133 C CG2 . THR B 2 276 ? 191.432 226.846 342.235 1.00 44.88  ? 276 THR B CG2 1 
ATOM 3134 N N   . LEU B 2 277 ? 191.673 229.626 344.025 1.00 48.48  ? 277 LEU B N   1 
ATOM 3135 C CA  . LEU B 2 277 ? 192.440 230.835 343.758 1.00 41.18  ? 277 LEU B CA  1 
ATOM 3136 C C   . LEU B 2 277 ? 193.839 230.450 343.304 1.00 36.49  ? 277 LEU B C   1 
ATOM 3137 O O   . LEU B 2 277 ? 194.498 229.632 343.950 1.00 46.44  ? 277 LEU B O   1 
ATOM 3138 C CB  . LEU B 2 277 ? 192.528 231.725 345.000 1.00 39.00  ? 277 LEU B CB  1 
ATOM 3139 C CG  . LEU B 2 277 ? 191.286 232.529 345.383 1.00 40.16  ? 277 LEU B CG  1 
ATOM 3140 C CD1 . LEU B 2 277 ? 190.153 231.615 345.782 1.00 49.06  ? 277 LEU B CD1 1 
ATOM 3141 C CD2 . LEU B 2 277 ? 191.608 233.492 346.505 1.00 42.99  ? 277 LEU B CD2 1 
ATOM 3142 N N   . VAL B 2 278 ? 194.292 231.042 342.207 1.00 41.57  ? 278 VAL B N   1 
ATOM 3143 C CA  . VAL B 2 278 ? 195.635 230.818 341.686 1.00 43.93  ? 278 VAL B CA  1 
ATOM 3144 C C   . VAL B 2 278 ? 196.421 232.100 341.927 1.00 51.69  ? 278 VAL B C   1 
ATOM 3145 O O   . VAL B 2 278 ? 196.266 233.083 341.197 1.00 57.63  ? 278 VAL B O   1 
ATOM 3146 C CB  . VAL B 2 278 ? 195.620 230.437 340.204 1.00 45.04  ? 278 VAL B CB  1 
ATOM 3147 C CG1 . VAL B 2 278 ? 197.033 230.232 339.699 1.00 49.17  ? 278 VAL B CG1 1 
ATOM 3148 C CG2 . VAL B 2 278 ? 194.790 229.189 339.989 1.00 47.17  ? 278 VAL B CG2 1 
ATOM 3149 N N   . LEU B 2 279 ? 197.275 232.092 342.951 1.00 41.37  ? 279 LEU B N   1 
ATOM 3150 C CA  . LEU B 2 279 ? 197.993 233.278 343.375 1.00 33.40  ? 279 LEU B CA  1 
ATOM 3151 C C   . LEU B 2 279 ? 199.379 233.289 342.757 1.00 42.05  ? 279 LEU B C   1 
ATOM 3152 O O   . LEU B 2 279 ? 200.156 232.357 343.008 1.00 49.83  ? 279 LEU B O   1 
ATOM 3153 C CB  . LEU B 2 279 ? 198.101 233.304 344.892 1.00 34.16  ? 279 LEU B CB  1 
ATOM 3154 C CG  . LEU B 2 279 ? 196.785 233.232 345.656 1.00 35.49  ? 279 LEU B CG  1 
ATOM 3155 C CD1 . LEU B 2 279 ? 197.038 233.278 347.144 1.00 37.32  ? 279 LEU B CD1 1 
ATOM 3156 C CD2 . LEU B 2 279 ? 195.865 234.354 345.238 1.00 41.36  ? 279 LEU B CD2 1 
ATOM 3157 N N   . PRO B 2 280 ? 199.740 234.285 341.956 1.00 49.76  ? 280 PRO B N   1 
ATOM 3158 C CA  . PRO B 2 280 ? 201.125 234.424 341.504 1.00 47.44  ? 280 PRO B CA  1 
ATOM 3159 C C   . PRO B 2 280 ? 201.983 235.056 342.596 1.00 43.63  ? 280 PRO B C   1 
ATOM 3160 O O   . PRO B 2 280 ? 201.506 235.414 343.668 1.00 49.01  ? 280 PRO B O   1 
ATOM 3161 C CB  . PRO B 2 280 ? 200.998 235.331 340.282 1.00 46.75  ? 280 PRO B CB  1 
ATOM 3162 C CG  . PRO B 2 280 ? 199.827 236.164 340.576 1.00 46.30  ? 280 PRO B CG  1 
ATOM 3163 C CD  . PRO B 2 280 ? 198.870 235.297 341.333 1.00 48.32  ? 280 PRO B CD  1 
ATOM 3164 N N   . TYR B 2 281 ? 203.272 235.189 342.303 1.00 37.88  ? 281 TYR B N   1 
ATOM 3165 C CA  . TYR B 2 281 ? 204.213 235.740 343.268 1.00 45.78  ? 281 TYR B CA  1 
ATOM 3166 C C   . TYR B 2 281 ? 204.164 237.262 343.220 1.00 50.76  ? 281 TYR B C   1 
ATOM 3167 O O   . TYR B 2 281 ? 204.378 237.863 342.163 1.00 47.82  ? 281 TYR B O   1 
ATOM 3168 C CB  . TYR B 2 281 ? 205.628 235.244 342.986 1.00 48.34  ? 281 TYR B CB  1 
ATOM 3169 C CG  . TYR B 2 281 ? 206.625 235.706 344.014 1.00 46.31  ? 281 TYR B CG  1 
ATOM 3170 C CD1 . TYR B 2 281 ? 206.647 235.147 345.279 1.00 45.79  ? 281 TYR B CD1 1 
ATOM 3171 C CD2 . TYR B 2 281 ? 207.537 236.705 343.725 1.00 48.02  ? 281 TYR B CD2 1 
ATOM 3172 C CE1 . TYR B 2 281 ? 207.549 235.566 346.223 1.00 46.12  ? 281 TYR B CE1 1 
ATOM 3173 C CE2 . TYR B 2 281 ? 208.442 237.131 344.665 1.00 47.32  ? 281 TYR B CE2 1 
ATOM 3174 C CZ  . TYR B 2 281 ? 208.444 236.557 345.912 1.00 51.73  ? 281 TYR B CZ  1 
ATOM 3175 O OH  . TYR B 2 281 ? 209.343 236.972 346.860 1.00 58.08  ? 281 TYR B OH  1 
ATOM 3176 N N   . VAL B 2 282 ? 203.889 237.879 344.364 1.00 49.78  ? 282 VAL B N   1 
ATOM 3177 C CA  . VAL B 2 282 ? 203.779 239.327 344.484 1.00 41.39  ? 282 VAL B CA  1 
ATOM 3178 C C   . VAL B 2 282 ? 204.783 239.785 345.528 1.00 45.00  ? 282 VAL B C   1 
ATOM 3179 O O   . VAL B 2 282 ? 204.766 239.304 346.667 1.00 51.28  ? 282 VAL B O   1 
ATOM 3180 C CB  . VAL B 2 282 ? 202.355 239.760 344.864 1.00 44.97  ? 282 VAL B CB  1 
ATOM 3181 C CG1 . VAL B 2 282 ? 202.361 241.130 345.511 1.00 43.76  ? 282 VAL B CG1 1 
ATOM 3182 C CG2 . VAL B 2 282 ? 201.465 239.763 343.639 1.00 47.20  ? 282 VAL B CG2 1 
ATOM 3183 N N   . ASN B 2 283 ? 205.649 240.716 345.142 1.00 49.16  ? 283 ASN B N   1 
ATOM 3184 C CA  . ASN B 2 283 ? 206.633 241.288 346.047 1.00 45.82  ? 283 ASN B CA  1 
ATOM 3185 C C   . ASN B 2 283 ? 207.359 242.394 345.304 1.00 44.50  ? 283 ASN B C   1 
ATOM 3186 O O   . ASN B 2 283 ? 207.448 242.369 344.074 1.00 47.08  ? 283 ASN B O   1 
ATOM 3187 C CB  . ASN B 2 283 ? 207.628 240.231 346.540 1.00 46.77  ? 283 ASN B CB  1 
ATOM 3188 C CG  . ASN B 2 283 ? 208.392 240.677 347.765 1.00 51.44  ? 283 ASN B CG  1 
ATOM 3189 O OD1 . ASN B 2 283 ? 207.970 241.581 348.481 1.00 55.67  ? 283 ASN B OD1 1 
ATOM 3190 N ND2 . ASN B 2 283 ? 209.525 240.037 348.016 1.00 50.78  ? 283 ASN B ND2 1 
ATOM 3191 N N   . SER B 2 284 ? 207.872 243.366 346.060 1.00 44.63  ? 284 SER B N   1 
ATOM 3192 C CA  . SER B 2 284 ? 208.624 244.452 345.442 1.00 41.68  ? 284 SER B CA  1 
ATOM 3193 C C   . SER B 2 284 ? 209.983 243.980 344.947 1.00 48.81  ? 284 SER B C   1 
ATOM 3194 O O   . SER B 2 284 ? 210.529 244.560 344.005 1.00 53.89  ? 284 SER B O   1 
ATOM 3195 C CB  . SER B 2 284 ? 208.791 245.605 346.426 1.00 41.22  ? 284 SER B CB  1 
ATOM 3196 O OG  . SER B 2 284 ? 209.473 245.185 347.588 1.00 45.74  ? 284 SER B OG  1 
ATOM 3197 N N   . LEU B 2 285 ? 210.538 242.938 345.558 1.00 50.33  ? 285 LEU B N   1 
ATOM 3198 C CA  . LEU B 2 285 ? 211.795 242.342 345.133 1.00 43.48  ? 285 LEU B CA  1 
ATOM 3199 C C   . LEU B 2 285 ? 211.525 241.116 344.273 1.00 49.94  ? 285 LEU B C   1 
ATOM 3200 O O   . LEU B 2 285 ? 210.500 240.448 344.417 1.00 58.51  ? 285 LEU B O   1 
ATOM 3201 C CB  . LEU B 2 285 ? 212.643 241.940 346.338 1.00 47.52  ? 285 LEU B CB  1 
ATOM 3202 C CG  . LEU B 2 285 ? 212.948 243.059 347.327 1.00 47.21  ? 285 LEU B CG  1 
ATOM 3203 C CD1 . LEU B 2 285 ? 213.561 242.506 348.594 1.00 48.00  ? 285 LEU B CD1 1 
ATOM 3204 C CD2 . LEU B 2 285 ? 213.869 244.069 346.687 1.00 50.58  ? 285 LEU B CD2 1 
ATOM 3205 N N   . SER B 2 286 ? 212.463 240.822 343.373 1.00 48.94  ? 286 SER B N   1 
ATOM 3206 C CA  . SER B 2 286 ? 212.311 239.669 342.495 1.00 51.50  ? 286 SER B CA  1 
ATOM 3207 C C   . SER B 2 286 ? 212.442 238.346 343.241 1.00 52.19  ? 286 SER B C   1 
ATOM 3208 O O   . SER B 2 286 ? 212.057 237.305 342.700 1.00 50.84  ? 286 SER B O   1 
ATOM 3209 C CB  . SER B 2 286 ? 213.339 239.737 341.369 1.00 48.48  ? 286 SER B CB  1 
ATOM 3210 O OG  . SER B 2 286 ? 213.109 238.722 340.412 1.00 57.01  ? 286 SER B OG  1 
ATOM 3211 N N   . ILE B 2 287 ? 212.980 238.364 344.459 1.00 50.08  ? 287 ILE B N   1 
ATOM 3212 C CA  . ILE B 2 287 ? 213.122 237.168 345.283 1.00 49.63  ? 287 ILE B CA  1 
ATOM 3213 C C   . ILE B 2 287 ? 213.453 237.628 346.694 1.00 50.25  ? 287 ILE B C   1 
ATOM 3214 O O   . ILE B 2 287 ? 214.115 238.653 346.875 1.00 60.66  ? 287 ILE B O   1 
ATOM 3215 C CB  . ILE B 2 287 ? 214.205 236.229 344.728 1.00 52.40  ? 287 ILE B CB  1 
ATOM 3216 C CG1 . ILE B 2 287 ? 214.049 234.828 345.310 1.00 53.81  ? 287 ILE B CG1 1 
ATOM 3217 C CG2 . ILE B 2 287 ? 215.583 236.768 345.053 1.00 51.21  ? 287 ILE B CG2 1 
ATOM 3218 C CD1 . ILE B 2 287 ? 214.906 233.790 344.628 1.00 51.18  ? 287 ILE B CD1 1 
ATOM 3219 N N   . ASP B 2 288 ? 213.009 236.886 347.704 1.00 51.58  ? 288 ASP B N   1 
ATOM 3220 C CA  . ASP B 2 288 ? 213.146 237.358 349.074 1.00 58.13  ? 288 ASP B CA  1 
ATOM 3221 C C   . ASP B 2 288 ? 213.208 236.175 350.028 1.00 58.87  ? 288 ASP B C   1 
ATOM 3222 O O   . ASP B 2 288 ? 212.878 235.042 349.670 1.00 58.70  ? 288 ASP B O   1 
ATOM 3223 C CB  . ASP B 2 288 ? 211.990 238.294 349.445 1.00 58.12  ? 288 ASP B CB  1 
ATOM 3224 C CG  . ASP B 2 288 ? 212.246 239.068 350.721 1.00 59.30  ? 288 ASP B CG  1 
ATOM 3225 O OD1 . ASP B 2 288 ? 213.008 238.579 351.577 1.00 60.47  ? 288 ASP B OD1 1 
ATOM 3226 O OD2 . ASP B 2 288 ? 211.679 240.168 350.870 1.00 64.87  ? 288 ASP B OD2 1 
ATOM 3227 N N   . SER B 2 289 ? 213.642 236.460 351.254 1.00 60.77  ? 289 SER B N   1 
ATOM 3228 C CA  . SER B 2 289 ? 213.749 235.445 352.294 1.00 58.29  ? 289 SER B CA  1 
ATOM 3229 C C   . SER B 2 289 ? 212.365 235.050 352.789 1.00 60.57  ? 289 SER B C   1 
ATOM 3230 O O   . SER B 2 289 ? 211.620 235.888 353.304 1.00 61.41  ? 289 SER B O   1 
ATOM 3231 C CB  . SER B 2 289 ? 214.594 235.979 353.446 1.00 60.34  ? 289 SER B CB  1 
ATOM 3232 O OG  . SER B 2 289 ? 214.573 235.100 354.555 1.00 62.92  ? 289 SER B OG  1 
ATOM 3233 N N   . MET B 2 290 ? 212.030 233.765 352.655 1.00 65.39  ? 290 MET B N   1 
ATOM 3234 C CA  . MET B 2 290 ? 210.701 233.299 353.037 1.00 62.19  ? 290 MET B CA  1 
ATOM 3235 C C   . MET B 2 290 ? 210.511 233.279 354.547 1.00 64.21  ? 290 MET B C   1 
ATOM 3236 O O   . MET B 2 290 ? 209.392 233.478 355.029 1.00 64.13  ? 290 MET B O   1 
ATOM 3237 C CB  . MET B 2 290 ? 210.453 231.904 352.467 1.00 58.37  ? 290 MET B CB  1 
ATOM 3238 C CG  . MET B 2 290 ? 210.031 231.892 351.013 1.00 56.42  ? 290 MET B CG  1 
ATOM 3239 S SD  . MET B 2 290 ? 209.513 230.256 350.472 1.00 77.59  ? 290 MET B SD  1 
ATOM 3240 C CE  . MET B 2 290 ? 208.683 230.649 348.936 1.00 64.52  ? 290 MET B CE  1 
ATOM 3241 N N   . VAL B 2 291 ? 211.576 233.027 355.309 1.00 66.56  ? 291 VAL B N   1 
ATOM 3242 C CA  . VAL B 2 291 ? 211.430 232.831 356.745 1.00 67.84  ? 291 VAL B CA  1 
ATOM 3243 C C   . VAL B 2 291 ? 210.991 234.099 357.464 1.00 69.84  ? 291 VAL B C   1 
ATOM 3244 O O   . VAL B 2 291 ? 210.448 234.018 358.571 1.00 71.18  ? 291 VAL B O   1 
ATOM 3245 C CB  . VAL B 2 291 ? 212.747 232.304 357.341 1.00 68.66  ? 291 VAL B CB  1 
ATOM 3246 C CG1 . VAL B 2 291 ? 212.647 232.200 358.854 1.00 66.61  ? 291 VAL B CG1 1 
ATOM 3247 C CG2 . VAL B 2 291 ? 213.091 230.956 356.735 1.00 71.41  ? 291 VAL B CG2 1 
ATOM 3248 N N   . LYS B 2 292 ? 211.211 235.274 356.873 1.00 66.56  ? 292 LYS B N   1 
ATOM 3249 C CA  . LYS B 2 292 ? 210.903 236.535 357.533 1.00 64.45  ? 292 LYS B CA  1 
ATOM 3250 C C   . LYS B 2 292 ? 209.709 237.268 356.942 1.00 69.85  ? 292 LYS B C   1 
ATOM 3251 O O   . LYS B 2 292 ? 209.134 238.120 357.624 1.00 69.39  ? 292 LYS B O   1 
ATOM 3252 C CB  . LYS B 2 292 ? 212.116 237.473 357.472 1.00 70.12  ? 292 LYS B CB  1 
ATOM 3253 C CG  . LYS B 2 292 ? 213.458 236.770 357.587 1.00 73.91  ? 292 LYS B CG  1 
ATOM 3254 C CD  . LYS B 2 292 ? 214.602 237.765 357.691 1.00 69.61  ? 292 LYS B CD  1 
ATOM 3255 C CE  . LYS B 2 292 ? 215.927 237.060 357.904 1.00 70.03  ? 292 LYS B CE  1 
ATOM 3256 N NZ  . LYS B 2 292 ? 217.058 238.017 358.026 1.00 70.95  ? 292 LYS B NZ  1 
ATOM 3257 N N   . HIS B 2 293 ? 209.321 236.962 355.707 1.00 67.62  ? 293 HIS B N   1 
ATOM 3258 C CA  . HIS B 2 293 ? 208.348 237.755 354.970 1.00 62.44  ? 293 HIS B CA  1 
ATOM 3259 C C   . HIS B 2 293 ? 207.211 236.866 354.491 1.00 61.79  ? 293 HIS B C   1 
ATOM 3260 O O   . HIS B 2 293 ? 207.453 235.815 353.891 1.00 65.63  ? 293 HIS B O   1 
ATOM 3261 C CB  . HIS B 2 293 ? 209.023 238.445 353.782 1.00 58.11  ? 293 HIS B CB  1 
ATOM 3262 C CG  . HIS B 2 293 ? 208.177 239.490 353.130 1.00 64.86  ? 293 HIS B CG  1 
ATOM 3263 N ND1 . HIS B 2 293 ? 207.444 240.407 353.850 1.00 64.73  ? 293 HIS B ND1 1 
ATOM 3264 C CD2 . HIS B 2 293 ? 207.952 239.767 351.825 1.00 60.91  ? 293 HIS B CD2 1 
ATOM 3265 C CE1 . HIS B 2 293 ? 206.800 241.202 353.017 1.00 63.49  ? 293 HIS B CE1 1 
ATOM 3266 N NE2 . HIS B 2 293 ? 207.091 240.836 351.782 1.00 62.86  ? 293 HIS B NE2 1 
ATOM 3267 N N   . ASN B 2 294 ? 205.978 237.295 354.743 1.00 53.46  ? 294 ASN B N   1 
ATOM 3268 C CA  . ASN B 2 294 ? 204.787 236.578 354.308 1.00 51.20  ? 294 ASN B CA  1 
ATOM 3269 C C   . ASN B 2 294 ? 204.210 237.275 353.083 1.00 53.74  ? 294 ASN B C   1 
ATOM 3270 O O   . ASN B 2 294 ? 203.758 238.420 353.171 1.00 51.47  ? 294 ASN B O   1 
ATOM 3271 C CB  . ASN B 2 294 ? 203.750 236.520 355.426 1.00 54.30  ? 294 ASN B CB  1 
ATOM 3272 C CG  . ASN B 2 294 ? 204.184 235.644 356.574 1.00 58.91  ? 294 ASN B CG  1 
ATOM 3273 O OD1 . ASN B 2 294 ? 204.704 234.552 356.371 1.00 58.21  ? 294 ASN B OD1 1 
ATOM 3274 N ND2 . ASN B 2 294 ? 203.980 236.122 357.793 1.00 60.83  ? 294 ASN B ND2 1 
ATOM 3275 N N   . ASN B 2 295 ? 204.221 236.580 351.946 1.00 54.25  ? 295 ASN B N   1 
ATOM 3276 C CA  . ASN B 2 295 ? 203.741 237.184 350.708 1.00 50.16  ? 295 ASN B CA  1 
ATOM 3277 C C   . ASN B 2 295 ? 202.238 237.427 350.749 1.00 53.32  ? 295 ASN B C   1 
ATOM 3278 O O   . ASN B 2 295 ? 201.773 238.524 350.419 1.00 55.29  ? 295 ASN B O   1 
ATOM 3279 C CB  . ASN B 2 295 ? 204.095 236.295 349.520 1.00 48.60  ? 295 ASN B CB  1 
ATOM 3280 C CG  . ASN B 2 295 ? 205.478 236.560 348.985 1.00 55.48  ? 295 ASN B CG  1 
ATOM 3281 O OD1 . ASN B 2 295 ? 206.300 235.652 348.883 1.00 58.54  ? 295 ASN B OD1 1 
ATOM 3282 N ND2 . ASN B 2 295 ? 205.746 237.810 348.634 1.00 57.22  ? 295 ASN B ND2 1 
ATOM 3283 N N   . TRP B 2 296 ? 201.458 236.418 351.143 1.00 48.43  ? 296 TRP B N   1 
ATOM 3284 C CA  . TRP B 2 296 ? 200.008 236.478 351.014 1.00 30.79  ? 296 TRP B CA  1 
ATOM 3285 C C   . TRP B 2 296 ? 199.337 236.187 352.347 1.00 35.59  ? 296 TRP B C   1 
ATOM 3286 O O   . TRP B 2 296 ? 199.916 235.568 353.240 1.00 50.36  ? 296 TRP B O   1 
ATOM 3287 C CB  . TRP B 2 296 ? 199.479 235.475 349.984 1.00 28.64  ? 296 TRP B CB  1 
ATOM 3288 C CG  . TRP B 2 296 ? 199.831 235.744 348.554 1.00 36.51  ? 296 TRP B CG  1 
ATOM 3289 C CD1 . TRP B 2 296 ? 200.896 235.247 347.870 1.00 43.60  ? 296 TRP B CD1 1 
ATOM 3290 C CD2 . TRP B 2 296 ? 199.098 236.544 347.622 1.00 40.08  ? 296 TRP B CD2 1 
ATOM 3291 N NE1 . TRP B 2 296 ? 200.880 235.691 346.574 1.00 40.35  ? 296 TRP B NE1 1 
ATOM 3292 C CE2 . TRP B 2 296 ? 199.785 236.493 346.396 1.00 36.86  ? 296 TRP B CE2 1 
ATOM 3293 C CE3 . TRP B 2 296 ? 197.930 237.305 347.705 1.00 43.54  ? 296 TRP B CE3 1 
ATOM 3294 C CZ2 . TRP B 2 296 ? 199.344 237.171 345.267 1.00 36.85  ? 296 TRP B CZ2 1 
ATOM 3295 C CZ3 . TRP B 2 296 ? 197.498 237.977 346.582 1.00 35.05  ? 296 TRP B CZ3 1 
ATOM 3296 C CH2 . TRP B 2 296 ? 198.200 237.904 345.381 1.00 38.22  ? 296 TRP B CH2 1 
ATOM 3297 N N   . GLY B 2 297 ? 198.100 236.627 352.460 1.00 37.15  ? 297 GLY B N   1 
ATOM 3298 C CA  . GLY B 2 297 ? 197.239 236.219 353.557 1.00 42.12  ? 297 GLY B CA  1 
ATOM 3299 C C   . GLY B 2 297 ? 195.897 235.795 353.007 1.00 48.40  ? 297 GLY B C   1 
ATOM 3300 O O   . GLY B 2 297 ? 195.398 236.377 352.049 1.00 53.53  ? 297 GLY B O   1 
ATOM 3301 N N   . ILE B 2 298 ? 195.326 234.759 353.609 1.00 35.86  ? 298 ILE B N   1 
ATOM 3302 C CA  . ILE B 2 298 ? 194.052 234.203 353.175 1.00 33.37  ? 298 ILE B CA  1 
ATOM 3303 C C   . ILE B 2 298 ? 193.053 234.398 354.299 1.00 38.37  ? 298 ILE B C   1 
ATOM 3304 O O   . ILE B 2 298 ? 193.314 233.998 355.438 1.00 41.37  ? 298 ILE B O   1 
ATOM 3305 C CB  . ILE B 2 298 ? 194.174 232.715 352.809 1.00 31.85  ? 298 ILE B CB  1 
ATOM 3306 C CG1 . ILE B 2 298 ? 195.298 232.507 351.796 1.00 40.25  ? 298 ILE B CG1 1 
ATOM 3307 C CG2 . ILE B 2 298 ? 192.869 232.201 352.255 1.00 39.23  ? 298 ILE B CG2 1 
ATOM 3308 C CD1 . ILE B 2 298 ? 195.154 233.318 350.532 1.00 38.50  ? 298 ILE B CD1 1 
ATOM 3309 N N   . ALA B 2 299 ? 191.919 235.019 353.986 1.00 38.73  ? 299 ALA B N   1 
ATOM 3310 C CA  . ALA B 2 299 ? 190.875 235.275 354.966 1.00 38.47  ? 299 ALA B CA  1 
ATOM 3311 C C   . ALA B 2 299 ? 189.567 234.657 354.495 1.00 42.04  ? 299 ALA B C   1 
ATOM 3312 O O   . ALA B 2 299 ? 189.234 234.713 353.309 1.00 47.64  ? 299 ALA B O   1 
ATOM 3313 C CB  . ALA B 2 299 ? 190.691 236.773 355.198 1.00 39.56  ? 299 ALA B CB  1 
ATOM 3314 N N   . ILE B 2 300 ? 188.836 234.057 355.429 1.00 32.12  ? 300 ILE B N   1 
ATOM 3315 C CA  . ILE B 2 300 ? 187.541 233.450 355.160 1.00 33.68  ? 300 ILE B CA  1 
ATOM 3316 C C   . ILE B 2 300 ? 186.551 234.036 356.153 1.00 33.38  ? 300 ILE B C   1 
ATOM 3317 O O   . ILE B 2 300 ? 186.745 233.917 357.369 1.00 32.92  ? 300 ILE B O   1 
ATOM 3318 C CB  . ILE B 2 300 ? 187.589 231.919 355.270 1.00 37.66  ? 300 ILE B CB  1 
ATOM 3319 C CG1 . ILE B 2 300 ? 188.572 231.362 354.240 1.00 37.73  ? 300 ILE B CG1 1 
ATOM 3320 C CG2 . ILE B 2 300 ? 186.210 231.327 355.064 1.00 26.06  ? 300 ILE B CG2 1 
ATOM 3321 C CD1 . ILE B 2 300 ? 188.792 229.883 354.334 1.00 40.69  ? 300 ILE B CD1 1 
ATOM 3322 N N   . LEU B 2 301 ? 185.495 234.664 355.638 1.00 39.01  ? 301 LEU B N   1 
ATOM 3323 C CA  . LEU B 2 301 ? 184.539 235.379 356.471 1.00 32.12  ? 301 LEU B CA  1 
ATOM 3324 C C   . LEU B 2 301 ? 183.118 234.969 356.104 1.00 36.82  ? 301 LEU B C   1 
ATOM 3325 O O   . LEU B 2 301 ? 182.779 234.924 354.911 1.00 38.12  ? 301 LEU B O   1 
ATOM 3326 C CB  . LEU B 2 301 ? 184.715 236.891 356.306 1.00 38.55  ? 301 LEU B CB  1 
ATOM 3327 C CG  . LEU B 2 301 ? 185.972 237.480 356.945 1.00 41.73  ? 301 LEU B CG  1 
ATOM 3328 C CD1 . LEU B 2 301 ? 186.326 238.801 356.305 1.00 45.69  ? 301 LEU B CD1 1 
ATOM 3329 C CD2 . LEU B 2 301 ? 185.771 237.652 358.434 1.00 42.19  ? 301 LEU B CD2 1 
ATOM 3330 N N   . PRO B 2 302 ? 182.255 234.671 357.081 1.00 37.29  ? 302 PRO B N   1 
ATOM 3331 C CA  . PRO B 2 302 ? 180.855 234.351 356.774 1.00 43.69  ? 302 PRO B CA  1 
ATOM 3332 C C   . PRO B 2 302 ? 180.049 235.604 356.469 1.00 43.27  ? 302 PRO B C   1 
ATOM 3333 O O   . PRO B 2 302 ? 179.787 236.426 357.352 1.00 38.73  ? 302 PRO B O   1 
ATOM 3334 C CB  . PRO B 2 302 ? 180.373 233.656 358.055 1.00 38.10  ? 302 PRO B CB  1 
ATOM 3335 C CG  . PRO B 2 302 ? 181.203 234.227 359.113 1.00 35.31  ? 302 PRO B CG  1 
ATOM 3336 C CD  . PRO B 2 302 ? 182.551 234.470 358.508 1.00 39.75  ? 302 PRO B CD  1 
ATOM 3337 N N   . LEU B 2 303 ? 179.644 235.749 355.207 1.00 40.88  ? 303 LEU B N   1 
ATOM 3338 C CA  . LEU B 2 303 ? 178.841 236.902 354.818 1.00 30.60  ? 303 LEU B CA  1 
ATOM 3339 C C   . LEU B 2 303 ? 177.406 236.762 355.307 1.00 42.21  ? 303 LEU B C   1 
ATOM 3340 O O   . LEU B 2 303 ? 176.808 237.737 355.774 1.00 53.30  ? 303 LEU B O   1 
ATOM 3341 C CB  . LEU B 2 303 ? 178.879 237.076 353.303 1.00 27.16  ? 303 LEU B CB  1 
ATOM 3342 C CG  . LEU B 2 303 ? 180.268 237.270 352.694 1.00 31.85  ? 303 LEU B CG  1 
ATOM 3343 C CD1 . LEU B 2 303 ? 180.171 237.447 351.197 1.00 34.68  ? 303 LEU B CD1 1 
ATOM 3344 C CD2 . LEU B 2 303 ? 180.974 238.450 353.321 1.00 41.78  ? 303 LEU B CD2 1 
ATOM 3345 N N   . ALA B 2 304 ? 176.835 235.567 355.202 1.00 33.85  ? 304 ALA B N   1 
ATOM 3346 C CA  . ALA B 2 304 ? 175.520 235.272 355.735 1.00 31.60  ? 304 ALA B CA  1 
ATOM 3347 C C   . ALA B 2 304 ? 175.619 234.081 356.677 1.00 36.83  ? 304 ALA B C   1 
ATOM 3348 O O   . ALA B 2 304 ? 176.159 233.038 356.285 1.00 45.81  ? 304 ALA B O   1 
ATOM 3349 C CB  . ALA B 2 304 ? 174.528 234.969 354.611 1.00 34.12  ? 304 ALA B CB  1 
ATOM 3350 N N   . PRO B 2 305 ? 175.111 234.176 357.903 1.00 34.27  ? 305 PRO B N   1 
ATOM 3351 C CA  . PRO B 2 305 ? 175.372 233.125 358.892 1.00 39.35  ? 305 PRO B CA  1 
ATOM 3352 C C   . PRO B 2 305 ? 174.832 231.775 358.444 1.00 39.58  ? 305 PRO B C   1 
ATOM 3353 O O   . PRO B 2 305 ? 174.137 231.645 357.436 1.00 38.50  ? 305 PRO B O   1 
ATOM 3354 C CB  . PRO B 2 305 ? 174.659 233.634 360.147 1.00 40.70  ? 305 PRO B CB  1 
ATOM 3355 C CG  . PRO B 2 305 ? 173.631 234.560 359.648 1.00 38.78  ? 305 PRO B CG  1 
ATOM 3356 C CD  . PRO B 2 305 ? 174.200 235.203 358.429 1.00 35.75  ? 305 PRO B CD  1 
ATOM 3357 N N   . LEU B 2 306 ? 175.176 230.748 359.217 1.00 37.40  ? 306 LEU B N   1 
ATOM 3358 C CA  . LEU B 2 306 ? 174.790 229.379 358.910 1.00 34.41  ? 306 LEU B CA  1 
ATOM 3359 C C   . LEU B 2 306 ? 173.439 229.070 359.535 1.00 39.56  ? 306 LEU B C   1 
ATOM 3360 O O   . LEU B 2 306 ? 173.189 229.419 360.691 1.00 40.44  ? 306 LEU B O   1 
ATOM 3361 C CB  . LEU B 2 306 ? 175.836 228.390 359.426 1.00 39.31  ? 306 LEU B CB  1 
ATOM 3362 C CG  . LEU B 2 306 ? 175.607 226.920 359.069 1.00 32.25  ? 306 LEU B CG  1 
ATOM 3363 C CD1 . LEU B 2 306 ? 175.997 226.651 357.629 1.00 34.40  ? 306 LEU B CD1 1 
ATOM 3364 C CD2 . LEU B 2 306 ? 176.368 226.013 360.006 1.00 30.77  ? 306 LEU B CD2 1 
ATOM 3365 N N   . ASN B 2 307 ? 172.575 228.412 358.769 1.00 42.41  ? 307 ASN B N   1 
ATOM 3366 C CA  . ASN B 2 307 ? 171.302 227.934 359.277 1.00 31.32  ? 307 ASN B CA  1 
ATOM 3367 C C   . ASN B 2 307 ? 170.953 226.641 358.560 1.00 39.62  ? 307 ASN B C   1 
ATOM 3368 O O   . ASN B 2 307 ? 171.441 226.367 357.462 1.00 38.84  ? 307 ASN B O   1 
ATOM 3369 C CB  . ASN B 2 307 ? 170.194 228.970 359.092 1.00 33.30  ? 307 ASN B CB  1 
ATOM 3370 C CG  . ASN B 2 307 ? 169.195 228.949 360.222 1.00 39.56  ? 307 ASN B CG  1 
ATOM 3371 O OD1 . ASN B 2 307 ? 169.065 227.951 360.926 1.00 41.69  ? 307 ASN B OD1 1 
ATOM 3372 N ND2 . ASN B 2 307 ? 168.483 230.053 360.406 1.00 41.69  ? 307 ASN B ND2 1 
ATOM 3373 N N   . PHE B 2 308 ? 170.099 225.844 359.196 1.00 42.67  ? 308 PHE B N   1 
ATOM 3374 C CA  . PHE B 2 308 ? 169.824 224.498 358.718 1.00 37.89  ? 308 PHE B CA  1 
ATOM 3375 C C   . PHE B 2 308 ? 168.470 224.042 359.236 1.00 44.46  ? 308 PHE B C   1 
ATOM 3376 O O   . PHE B 2 308 ? 167.908 224.630 360.163 1.00 47.43  ? 308 PHE B O   1 
ATOM 3377 C CB  . PHE B 2 308 ? 170.919 223.529 359.165 1.00 40.58  ? 308 PHE B CB  1 
ATOM 3378 C CG  . PHE B 2 308 ? 171.256 223.640 360.619 1.00 41.75  ? 308 PHE B CG  1 
ATOM 3379 C CD1 . PHE B 2 308 ? 170.486 223.007 361.570 1.00 37.44  ? 308 PHE B CD1 1 
ATOM 3380 C CD2 . PHE B 2 308 ? 172.338 224.388 361.034 1.00 41.71  ? 308 PHE B CD2 1 
ATOM 3381 C CE1 . PHE B 2 308 ? 170.785 223.113 362.901 1.00 37.18  ? 308 PHE B CE1 1 
ATOM 3382 C CE2 . PHE B 2 308 ? 172.643 224.500 362.366 1.00 38.30  ? 308 PHE B CE2 1 
ATOM 3383 C CZ  . PHE B 2 308 ? 171.865 223.860 363.302 1.00 39.67  ? 308 PHE B CZ  1 
ATOM 3384 N N   . ALA B 2 309 ? 167.957 222.979 358.622 1.00 49.38  ? 309 ALA B N   1 
ATOM 3385 C CA  . ALA B 2 309 ? 166.716 222.372 359.074 1.00 43.96  ? 309 ALA B CA  1 
ATOM 3386 C C   . ALA B 2 309 ? 166.932 221.633 360.389 1.00 47.99  ? 309 ALA B C   1 
ATOM 3387 O O   . ALA B 2 309 ? 168.032 221.170 360.692 1.00 57.59  ? 309 ALA B O   1 
ATOM 3388 C CB  . ALA B 2 309 ? 166.179 221.410 358.019 1.00 44.45  ? 309 ALA B CB  1 
ATOM 3389 N N   . SER B 2 310 ? 165.859 221.502 361.161 1.00 51.15  ? 310 SER B N   1 
ATOM 3390 C CA  . SER B 2 310 ? 165.964 220.934 362.497 1.00 50.83  ? 310 SER B CA  1 
ATOM 3391 C C   . SER B 2 310 ? 166.556 219.533 362.449 1.00 53.56  ? 310 SER B C   1 
ATOM 3392 O O   . SER B 2 310 ? 166.304 218.759 361.523 1.00 56.73  ? 310 SER B O   1 
ATOM 3393 C CB  . SER B 2 310 ? 164.589 220.890 363.160 1.00 53.25  ? 310 SER B CB  1 
ATOM 3394 O OG  . SER B 2 310 ? 164.056 222.192 363.304 1.00 60.32  ? 310 SER B OG  1 
ATOM 3395 N N   . GLU B 2 311 ? 167.358 219.213 363.463 1.00 60.60  ? 311 GLU B N   1 
ATOM 3396 C CA  . GLU B 2 311 ? 167.947 217.899 363.699 1.00 58.19  ? 311 GLU B CA  1 
ATOM 3397 C C   . GLU B 2 311 ? 169.075 217.565 362.734 1.00 56.95  ? 311 GLU B C   1 
ATOM 3398 O O   . GLU B 2 311 ? 169.525 216.417 362.713 1.00 58.49  ? 311 GLU B O   1 
ATOM 3399 C CB  . GLU B 2 311 ? 166.899 216.780 363.632 1.00 54.00  ? 311 GLU B CB  1 
ATOM 3400 C CG  . GLU B 2 311 ? 165.777 216.931 364.645 1.00 58.06  ? 311 GLU B CG  1 
ATOM 3401 C CD  . GLU B 2 311 ? 164.601 216.020 364.362 1.00 62.58  ? 311 GLU B CD  1 
ATOM 3402 O OE1 . GLU B 2 311 ? 164.337 215.734 363.177 1.00 64.07  ? 311 GLU B OE1 1 
ATOM 3403 O OE2 . GLU B 2 311 ? 163.938 215.589 365.326 1.00 63.36  ? 311 GLU B OE2 1 
ATOM 3404 N N   . SER B 2 312 ? 169.553 218.521 361.943 1.00 50.29  ? 312 SER B N   1 
ATOM 3405 C CA  . SER B 2 312 ? 170.645 218.276 361.012 1.00 44.18  ? 312 SER B CA  1 
ATOM 3406 C C   . SER B 2 312 ? 171.977 218.408 361.743 1.00 50.24  ? 312 SER B C   1 
ATOM 3407 O O   . SER B 2 312 ? 172.034 218.505 362.971 1.00 53.36  ? 312 SER B O   1 
ATOM 3408 C CB  . SER B 2 312 ? 170.550 219.233 359.832 1.00 44.68  ? 312 SER B CB  1 
ATOM 3409 O OG  . SER B 2 312 ? 169.240 219.241 359.308 1.00 50.50  ? 312 SER B OG  1 
ATOM 3410 N N   . SER B 2 313 ? 173.067 218.418 360.992 1.00 52.15  ? 313 SER B N   1 
ATOM 3411 C CA  . SER B 2 313 ? 174.388 218.576 361.584 1.00 48.37  ? 313 SER B CA  1 
ATOM 3412 C C   . SER B 2 313 ? 174.594 220.031 361.980 1.00 47.28  ? 313 SER B C   1 
ATOM 3413 O O   . SER B 2 313 ? 174.545 220.908 361.109 1.00 49.54  ? 313 SER B O   1 
ATOM 3414 C CB  . SER B 2 313 ? 175.458 218.139 360.598 1.00 47.77  ? 313 SER B CB  1 
ATOM 3415 O OG  . SER B 2 313 ? 175.252 216.800 360.193 1.00 52.13  ? 313 SER B OG  1 
ATOM 3416 N N   . PRO B 2 314 ? 174.841 220.339 363.254 1.00 42.60  ? 314 PRO B N   1 
ATOM 3417 C CA  . PRO B 2 314 ? 174.873 221.736 363.693 1.00 43.92  ? 314 PRO B CA  1 
ATOM 3418 C C   . PRO B 2 314 ? 176.161 222.481 363.377 1.00 46.28  ? 314 PRO B C   1 
ATOM 3419 O O   . PRO B 2 314 ? 176.328 223.607 363.849 1.00 48.84  ? 314 PRO B O   1 
ATOM 3420 C CB  . PRO B 2 314 ? 174.682 221.605 365.210 1.00 42.31  ? 314 PRO B CB  1 
ATOM 3421 C CG  . PRO B 2 314 ? 175.301 220.319 365.540 1.00 44.61  ? 314 PRO B CG  1 
ATOM 3422 C CD  . PRO B 2 314 ? 175.046 219.411 364.377 1.00 45.11  ? 314 PRO B CD  1 
ATOM 3423 N N   . GLU B 2 315 ? 177.070 221.896 362.603 1.00 43.47  ? 315 GLU B N   1 
ATOM 3424 C CA  . GLU B 2 315 ? 178.331 222.550 362.282 1.00 40.00  ? 315 GLU B CA  1 
ATOM 3425 C C   . GLU B 2 315 ? 179.019 221.821 361.141 1.00 39.56  ? 315 GLU B C   1 
ATOM 3426 O O   . GLU B 2 315 ? 179.234 220.611 361.228 1.00 49.56  ? 315 GLU B O   1 
ATOM 3427 C CB  . GLU B 2 315 ? 179.232 222.589 363.512 1.00 42.67  ? 315 GLU B CB  1 
ATOM 3428 C CG  . GLU B 2 315 ? 179.489 221.229 364.127 1.00 47.49  ? 315 GLU B CG  1 
ATOM 3429 C CD  . GLU B 2 315 ? 179.923 221.318 365.575 1.00 54.48  ? 315 GLU B CD  1 
ATOM 3430 O OE1 . GLU B 2 315 ? 180.130 222.446 366.066 1.00 53.83  ? 315 GLU B OE1 1 
ATOM 3431 O OE2 . GLU B 2 315 ? 180.053 220.260 366.223 1.00 54.73  ? 315 GLU B OE2 1 
ATOM 3432 N N   . ILE B 2 316 ? 179.383 222.533 360.079 1.00 33.73  ? 316 ILE B N   1 
ATOM 3433 C CA  . ILE B 2 316 ? 179.888 221.863 358.883 1.00 37.75  ? 316 ILE B CA  1 
ATOM 3434 C C   . ILE B 2 316 ? 181.381 222.125 358.718 1.00 42.36  ? 316 ILE B C   1 
ATOM 3435 O O   . ILE B 2 316 ? 181.886 223.151 359.182 1.00 44.79  ? 316 ILE B O   1 
ATOM 3436 C CB  . ILE B 2 316 ? 179.107 222.294 357.634 1.00 33.92  ? 316 ILE B CB  1 
ATOM 3437 C CG1 . ILE B 2 316 ? 179.399 223.749 357.285 1.00 38.41  ? 316 ILE B CG1 1 
ATOM 3438 C CG2 . ILE B 2 316 ? 177.628 222.104 357.864 1.00 37.31  ? 316 ILE B CG2 1 
ATOM 3439 C CD1 . ILE B 2 316 ? 178.615 224.244 356.113 1.00 43.31  ? 316 ILE B CD1 1 
ATOM 3440 N N   . PRO B 2 317 ? 182.122 221.235 358.067 1.00 42.26  ? 317 PRO B N   1 
ATOM 3441 C CA  . PRO B 2 317 ? 183.574 221.390 357.962 1.00 40.69  ? 317 PRO B CA  1 
ATOM 3442 C C   . PRO B 2 317 ? 184.032 222.103 356.699 1.00 41.92  ? 317 PRO B C   1 
ATOM 3443 O O   . PRO B 2 317 ? 183.471 221.943 355.616 1.00 49.21  ? 317 PRO B O   1 
ATOM 3444 C CB  . PRO B 2 317 ? 184.054 219.934 357.965 1.00 40.90  ? 317 PRO B CB  1 
ATOM 3445 C CG  . PRO B 2 317 ? 182.950 219.204 357.291 1.00 41.58  ? 317 PRO B CG  1 
ATOM 3446 C CD  . PRO B 2 317 ? 181.677 219.922 357.577 1.00 40.82  ? 317 PRO B CD  1 
ATOM 3447 N N   . ILE B 2 318 ? 185.096 222.889 356.860 1.00 39.48  ? 318 ILE B N   1 
ATOM 3448 C CA  . ILE B 2 318 ? 185.725 223.639 355.778 1.00 36.77  ? 318 ILE B CA  1 
ATOM 3449 C C   . ILE B 2 318 ? 187.169 223.177 355.675 1.00 41.96  ? 318 ILE B C   1 
ATOM 3450 O O   . ILE B 2 318 ? 187.881 223.134 356.684 1.00 49.56  ? 318 ILE B O   1 
ATOM 3451 C CB  . ILE B 2 318 ? 185.666 225.158 356.024 1.00 39.98  ? 318 ILE B CB  1 
ATOM 3452 C CG1 . ILE B 2 318 ? 184.246 225.592 356.372 1.00 36.98  ? 318 ILE B CG1 1 
ATOM 3453 C CG2 . ILE B 2 318 ? 186.151 225.916 354.799 1.00 40.02  ? 318 ILE B CG2 1 
ATOM 3454 C CD1 . ILE B 2 318 ? 184.114 227.062 356.641 1.00 32.71  ? 318 ILE B CD1 1 
ATOM 3455 N N   . THR B 2 319 ? 187.604 222.850 354.460 1.00 43.49  ? 319 THR B N   1 
ATOM 3456 C CA  . THR B 2 319 ? 188.913 222.261 354.220 1.00 35.15  ? 319 THR B CA  1 
ATOM 3457 C C   . THR B 2 319 ? 189.697 223.100 353.222 1.00 40.94  ? 319 THR B C   1 
ATOM 3458 O O   . THR B 2 319 ? 189.152 223.542 352.204 1.00 48.66  ? 319 THR B O   1 
ATOM 3459 C CB  . THR B 2 319 ? 188.776 220.833 353.690 1.00 44.77  ? 319 THR B CB  1 
ATOM 3460 O OG1 . THR B 2 319 ? 187.900 220.087 354.542 1.00 50.32  ? 319 THR B OG1 1 
ATOM 3461 C CG2 . THR B 2 319 ? 190.126 220.143 353.635 1.00 49.17  ? 319 THR B CG2 1 
ATOM 3462 N N   . LEU B 2 320 ? 190.981 223.299 353.516 1.00 43.24  ? 320 LEU B N   1 
ATOM 3463 C CA  . LEU B 2 320 ? 191.906 224.018 352.651 1.00 47.12  ? 320 LEU B CA  1 
ATOM 3464 C C   . LEU B 2 320 ? 192.949 223.067 352.087 1.00 44.67  ? 320 LEU B C   1 
ATOM 3465 O O   . LEU B 2 320 ? 193.431 222.175 352.788 1.00 41.79  ? 320 LEU B O   1 
ATOM 3466 C CB  . LEU B 2 320 ? 192.625 225.133 353.406 1.00 41.93  ? 320 LEU B CB  1 
ATOM 3467 C CG  . LEU B 2 320 ? 191.857 226.413 353.688 1.00 47.17  ? 320 LEU B CG  1 
ATOM 3468 C CD1 . LEU B 2 320 ? 190.818 226.186 354.769 1.00 46.34  ? 320 LEU B CD1 1 
ATOM 3469 C CD2 . LEU B 2 320 ? 192.833 227.497 354.083 1.00 46.19  ? 320 LEU B CD2 1 
ATOM 3470 N N   . THR B 2 321 ? 193.313 223.279 350.827 1.00 42.98  ? 321 THR B N   1 
ATOM 3471 C CA  . THR B 2 321 ? 194.326 222.473 350.162 1.00 34.00  ? 321 THR B CA  1 
ATOM 3472 C C   . THR B 2 321 ? 195.213 223.410 349.363 1.00 40.26  ? 321 THR B C   1 
ATOM 3473 O O   . THR B 2 321 ? 194.741 224.061 348.429 1.00 50.34  ? 321 THR B O   1 
ATOM 3474 C CB  . THR B 2 321 ? 193.677 221.429 349.252 1.00 47.33  ? 321 THR B CB  1 
ATOM 3475 O OG1 . THR B 2 321 ? 192.698 220.695 349.994 1.00 53.09  ? 321 THR B OG1 1 
ATOM 3476 C CG2 . THR B 2 321 ? 194.705 220.466 348.714 1.00 47.10  ? 321 THR B CG2 1 
ATOM 3477 N N   . ILE B 2 322 ? 196.491 223.469 349.722 1.00 45.85  ? 322 ILE B N   1 
ATOM 3478 C CA  . ILE B 2 322 ? 197.435 224.428 349.162 1.00 37.40  ? 322 ILE B CA  1 
ATOM 3479 C C   . ILE B 2 322 ? 198.486 223.664 348.377 1.00 42.42  ? 322 ILE B C   1 
ATOM 3480 O O   . ILE B 2 322 ? 199.021 222.661 348.860 1.00 52.03  ? 322 ILE B O   1 
ATOM 3481 C CB  . ILE B 2 322 ? 198.089 225.276 350.265 1.00 40.75  ? 322 ILE B CB  1 
ATOM 3482 C CG1 . ILE B 2 322 ? 197.020 225.930 351.140 1.00 45.80  ? 322 ILE B CG1 1 
ATOM 3483 C CG2 . ILE B 2 322 ? 198.976 226.335 349.652 1.00 50.19  ? 322 ILE B CG2 1 
ATOM 3484 C CD1 . ILE B 2 322 ? 197.545 226.464 352.444 1.00 46.85  ? 322 ILE B CD1 1 
ATOM 3485 N N   . ALA B 2 323 ? 198.772 224.126 347.167 1.00 46.52  ? 323 ALA B N   1 
ATOM 3486 C CA  . ALA B 2 323 ? 199.802 223.526 346.323 1.00 46.23  ? 323 ALA B CA  1 
ATOM 3487 C C   . ALA B 2 323 ? 200.756 224.607 345.844 1.00 50.03  ? 323 ALA B C   1 
ATOM 3488 O O   . ALA B 2 323 ? 200.330 225.509 345.094 1.00 61.74  ? 323 ALA B O   1 
ATOM 3489 C CB  . ALA B 2 323 ? 199.182 222.805 345.132 1.00 49.86  ? 323 ALA B CB  1 
ATOM 3490 N N   . PRO B 2 324 ? 202.025 224.582 346.248 1.00 49.57  ? 324 PRO B N   1 
ATOM 3491 C CA  . PRO B 2 324 ? 202.991 225.520 345.674 1.00 47.42  ? 324 PRO B CA  1 
ATOM 3492 C C   . PRO B 2 324 ? 203.209 225.261 344.193 1.00 48.16  ? 324 PRO B C   1 
ATOM 3493 O O   . PRO B 2 324 ? 203.052 224.142 343.702 1.00 53.28  ? 324 PRO B O   1 
ATOM 3494 C CB  . PRO B 2 324 ? 204.264 225.251 346.480 1.00 47.39  ? 324 PRO B CB  1 
ATOM 3495 C CG  . PRO B 2 324 ? 203.787 224.660 347.744 1.00 48.75  ? 324 PRO B CG  1 
ATOM 3496 C CD  . PRO B 2 324 ? 202.605 223.838 347.376 1.00 49.31  ? 324 PRO B CD  1 
ATOM 3497 N N   . MET B 2 325 ? 203.565 226.321 343.476 1.00 51.85  ? 325 MET B N   1 
ATOM 3498 C CA  . MET B 2 325 ? 203.782 226.255 342.041 1.00 57.74  ? 325 MET B CA  1 
ATOM 3499 C C   . MET B 2 325 ? 205.019 227.056 341.674 1.00 60.43  ? 325 MET B C   1 
ATOM 3500 O O   . MET B 2 325 ? 205.241 228.147 342.204 1.00 66.50  ? 325 MET B O   1 
ATOM 3501 C CB  . MET B 2 325 ? 202.582 226.801 341.264 1.00 57.31  ? 325 MET B CB  1 
ATOM 3502 C CG  . MET B 2 325 ? 201.292 226.048 341.491 1.00 58.31  ? 325 MET B CG  1 
ATOM 3503 S SD  . MET B 2 325 ? 199.904 226.823 340.650 1.00 69.92  ? 325 MET B SD  1 
ATOM 3504 C CE  . MET B 2 325 ? 200.484 226.799 338.959 1.00 59.55  ? 325 MET B CE  1 
ATOM 3505 N N   . CYS B 2 326 ? 205.812 226.512 340.755 1.00 61.64  ? 326 CYS B N   1 
ATOM 3506 C CA  . CYS B 2 326 ? 206.982 227.200 340.223 1.00 66.76  ? 326 CYS B CA  1 
ATOM 3507 C C   . CYS B 2 326 ? 207.890 227.687 341.348 1.00 69.16  ? 326 CYS B C   1 
ATOM 3508 O O   . CYS B 2 326 ? 208.358 228.827 341.357 1.00 70.74  ? 326 CYS B O   1 
ATOM 3509 C CB  . CYS B 2 326 ? 206.560 228.358 339.321 1.00 64.74  ? 326 CYS B CB  1 
ATOM 3510 S SG  . CYS B 2 326 ? 205.610 227.856 337.873 1.00 73.28  ? 326 CYS B SG  1 
ATOM 3511 N N   . CYS B 2 327 ? 208.138 226.806 342.313 1.00 66.01  ? 327 CYS B N   1 
ATOM 3512 C CA  . CYS B 2 327 ? 209.033 227.139 343.410 1.00 66.55  ? 327 CYS B CA  1 
ATOM 3513 C C   . CYS B 2 327 ? 210.476 227.167 342.929 1.00 68.06  ? 327 CYS B C   1 
ATOM 3514 O O   . CYS B 2 327 ? 210.839 226.515 341.948 1.00 69.74  ? 327 CYS B O   1 
ATOM 3515 C CB  . CYS B 2 327 ? 208.900 226.123 344.542 1.00 64.72  ? 327 CYS B CB  1 
ATOM 3516 S SG  . CYS B 2 327 ? 207.231 225.891 345.159 1.00 78.67  ? 327 CYS B SG  1 
ATOM 3517 N N   . GLU B 2 328 ? 211.307 227.935 343.631 1.00 66.51  ? 328 GLU B N   1 
ATOM 3518 C CA  . GLU B 2 328 ? 212.746 227.835 343.429 1.00 66.95  ? 328 GLU B CA  1 
ATOM 3519 C C   . GLU B 2 328 ? 213.461 228.566 344.554 1.00 64.17  ? 328 GLU B C   1 
ATOM 3520 O O   . GLU B 2 328 ? 213.020 229.634 344.986 1.00 61.14  ? 328 GLU B O   1 
ATOM 3521 C CB  . GLU B 2 328 ? 213.167 228.395 342.066 1.00 64.20  ? 328 GLU B CB  1 
ATOM 3522 C CG  . GLU B 2 328 ? 212.993 229.882 341.904 1.00 68.74  ? 328 GLU B CG  1 
ATOM 3523 C CD  . GLU B 2 328 ? 213.203 230.326 340.474 1.00 70.39  ? 328 GLU B CD  1 
ATOM 3524 O OE1 . GLU B 2 328 ? 212.551 229.757 339.576 1.00 71.84  ? 328 GLU B OE1 1 
ATOM 3525 O OE2 . GLU B 2 328 ? 214.028 231.233 340.245 1.00 69.61  ? 328 GLU B OE2 1 
ATOM 3526 N N   . PHE B 2 329 ? 214.567 227.978 345.014 1.00 58.67  ? 329 PHE B N   1 
ATOM 3527 C CA  . PHE B 2 329 ? 215.325 228.471 346.153 1.00 60.13  ? 329 PHE B CA  1 
ATOM 3528 C C   . PHE B 2 329 ? 216.798 228.593 345.788 1.00 60.77  ? 329 PHE B C   1 
ATOM 3529 O O   . PHE B 2 329 ? 217.297 227.908 344.893 1.00 62.24  ? 329 PHE B O   1 
ATOM 3530 C CB  . PHE B 2 329 ? 215.188 227.542 347.363 1.00 59.44  ? 329 PHE B CB  1 
ATOM 3531 C CG  . PHE B 2 329 ? 213.775 227.175 347.696 1.00 60.12  ? 329 PHE B CG  1 
ATOM 3532 C CD1 . PHE B 2 329 ? 213.129 226.165 347.011 1.00 61.13  ? 329 PHE B CD1 1 
ATOM 3533 C CD2 . PHE B 2 329 ? 213.099 227.826 348.710 1.00 60.02  ? 329 PHE B CD2 1 
ATOM 3534 C CE1 . PHE B 2 329 ? 211.832 225.820 347.321 1.00 64.06  ? 329 PHE B CE1 1 
ATOM 3535 C CE2 . PHE B 2 329 ? 211.803 227.486 349.024 1.00 58.32  ? 329 PHE B CE2 1 
ATOM 3536 C CZ  . PHE B 2 329 ? 211.169 226.482 348.329 1.00 60.68  ? 329 PHE B CZ  1 
ATOM 3537 N N   . ASN B 2 330 ? 217.493 229.474 346.507 1.00 62.13  ? 330 ASN B N   1 
ATOM 3538 C CA  . ASN B 2 330 ? 218.925 229.684 346.340 1.00 61.68  ? 330 ASN B CA  1 
ATOM 3539 C C   . ASN B 2 330 ? 219.575 229.903 347.699 1.00 59.56  ? 330 ASN B C   1 
ATOM 3540 O O   . ASN B 2 330 ? 218.947 230.411 348.632 1.00 65.28  ? 330 ASN B O   1 
ATOM 3541 C CB  . ASN B 2 330 ? 219.232 230.883 345.435 1.00 60.40  ? 330 ASN B CB  1 
ATOM 3542 C CG  . ASN B 2 330 ? 219.041 230.571 343.967 1.00 64.50  ? 330 ASN B CG  1 
ATOM 3543 O OD1 . ASN B 2 330 ? 218.109 229.869 343.586 1.00 66.29  ? 330 ASN B OD1 1 
ATOM 3544 N ND2 . ASN B 2 330 ? 219.935 231.086 343.133 1.00 67.13  ? 330 ASN B ND2 1 
ATOM 3545 N N   . GLY B 2 331 ? 220.849 229.525 347.794 1.00 51.39  ? 331 GLY B N   1 
ATOM 3546 C CA  . GLY B 2 331 ? 221.619 229.712 349.008 1.00 52.48  ? 331 GLY B CA  1 
ATOM 3547 C C   . GLY B 2 331 ? 221.490 228.569 349.993 1.00 55.46  ? 331 GLY B C   1 
ATOM 3548 O O   . GLY B 2 331 ? 221.174 228.789 351.164 1.00 54.29  ? 331 GLY B O   1 
ATOM 3549 N N   . LEU B 2 332 ? 221.765 227.347 349.539 1.00 61.99  ? 332 LEU B N   1 
ATOM 3550 C CA  . LEU B 2 332 ? 221.482 226.144 350.316 1.00 62.04  ? 332 LEU B CA  1 
ATOM 3551 C C   . LEU B 2 332 ? 222.512 225.981 351.426 1.00 58.60  ? 332 LEU B C   1 
ATOM 3552 O O   . LEU B 2 332 ? 223.717 225.916 351.164 1.00 56.73  ? 332 LEU B O   1 
ATOM 3553 C CB  . LEU B 2 332 ? 221.468 224.919 349.407 1.00 59.29  ? 332 LEU B CB  1 
ATOM 3554 C CG  . LEU B 2 332 ? 221.402 223.569 350.125 1.00 60.17  ? 332 LEU B CG  1 
ATOM 3555 C CD1 . LEU B 2 332 ? 220.225 223.516 351.080 1.00 60.94  ? 332 LEU B CD1 1 
ATOM 3556 C CD2 . LEU B 2 332 ? 221.327 222.433 349.125 1.00 63.15  ? 332 LEU B CD2 1 
ATOM 3557 N N   . ARG B 2 333 ? 222.034 225.896 352.662 1.00 64.60  ? 333 ARG B N   1 
ATOM 3558 C CA  . ARG B 2 333 ? 222.867 225.632 353.822 1.00 58.47  ? 333 ARG B CA  1 
ATOM 3559 C C   . ARG B 2 333 ? 222.907 224.134 354.106 1.00 68.74  ? 333 ARG B C   1 
ATOM 3560 O O   . ARG B 2 333 ? 222.240 223.331 353.451 1.00 75.99  ? 333 ARG B O   1 
ATOM 3561 C CB  . ARG B 2 333 ? 222.336 226.380 355.042 1.00 60.41  ? 333 ARG B CB  1 
ATOM 3562 C CG  . ARG B 2 333 ? 222.095 227.858 354.818 1.00 66.78  ? 333 ARG B CG  1 
ATOM 3563 C CD  . ARG B 2 333 ? 220.904 228.338 355.620 1.00 66.33  ? 333 ARG B CD  1 
ATOM 3564 N NE  . ARG B 2 333 ? 220.992 227.947 357.021 1.00 69.63  ? 333 ARG B NE  1 
ATOM 3565 C CZ  . ARG B 2 333 ? 220.090 228.256 357.941 1.00 67.10  ? 333 ARG B CZ  1 
ATOM 3566 N NH1 . ARG B 2 333 ? 219.012 228.962 357.643 1.00 64.64  ? 333 ARG B NH1 1 
ATOM 3567 N NH2 . ARG B 2 333 ? 220.274 227.848 359.192 1.00 70.66  ? 333 ARG B NH2 1 
ATOM 3568 N N   . ASN B 2 334 ? 223.697 223.759 355.107 1.00 76.75  ? 334 ASN B N   1 
ATOM 3569 C CA  . ASN B 2 334 ? 223.788 222.364 355.511 1.00 74.54  ? 334 ASN B CA  1 
ATOM 3570 C C   . ASN B 2 334 ? 222.613 221.982 356.399 1.00 74.68  ? 334 ASN B C   1 
ATOM 3571 O O   . ASN B 2 334 ? 221.859 222.836 356.870 1.00 78.79  ? 334 ASN B O   1 
ATOM 3572 C CB  . ASN B 2 334 ? 225.100 222.100 356.246 1.00 75.27  ? 334 ASN B CB  1 
ATOM 3573 C CG  . ASN B 2 334 ? 226.295 222.125 355.324 1.00 76.12  ? 334 ASN B CG  1 
ATOM 3574 O OD1 . ASN B 2 334 ? 226.294 221.490 354.270 1.00 76.30  ? 334 ASN B OD1 1 
ATOM 3575 N ND2 . ASN B 2 334 ? 227.330 222.859 355.719 1.00 74.74  ? 334 ASN B ND2 1 
ATOM 3576 N N   . ILE B 2 335 ? 222.466 220.679 356.621 1.00 72.82  ? 335 ILE B N   1 
ATOM 3577 C CA  . ILE B 2 335 ? 221.394 220.137 357.448 1.00 74.07  ? 335 ILE B CA  1 
ATOM 3578 C C   . ILE B 2 335 ? 220.070 220.280 356.711 1.00 72.26  ? 335 ILE B C   1 
ATOM 3579 O O   . ILE B 2 335 ? 219.477 219.290 356.287 1.00 70.45  ? 335 ILE B O   1 
ATOM 3580 C CB  . ILE B 2 335 ? 221.333 220.823 358.832 1.00 76.27  ? 335 ILE B CB  1 
ATOM 3581 C CG1 . ILE B 2 335 ? 222.699 220.762 359.520 1.00 75.13  ? 335 ILE B CG1 1 
ATOM 3582 C CG2 . ILE B 2 335 ? 220.279 220.159 359.707 1.00 75.03  ? 335 ILE B CG2 1 
ATOM 3583 C CD1 . ILE B 2 335 ? 222.778 221.560 360.800 1.00 71.81  ? 335 ILE B CD1 1 
ATOM 3584 N N   . GLY C 3 1   ? 223.772 290.370 324.005 1.00 34.67  ? 1   GLY C N   1 
ATOM 3585 C CA  . GLY C 3 1   ? 223.636 289.142 323.179 1.00 27.37  ? 1   GLY C CA  1 
ATOM 3586 C C   . GLY C 3 1   ? 222.370 289.150 322.352 1.00 33.62  ? 1   GLY C C   1 
ATOM 3587 O O   . GLY C 3 1   ? 222.295 289.822 321.329 1.00 42.95  ? 1   GLY C O   1 
ATOM 3588 N N   . LEU C 3 2   ? 221.383 288.390 322.789 1.00 26.52  ? 2   LEU C N   1 
ATOM 3589 C CA  . LEU C 3 2   ? 220.073 288.348 322.157 1.00 24.22  ? 2   LEU C CA  1 
ATOM 3590 C C   . LEU C 3 2   ? 219.124 289.280 322.888 1.00 33.91  ? 2   LEU C C   1 
ATOM 3591 O O   . LEU C 3 2   ? 219.013 289.186 324.119 1.00 34.84  ? 2   LEU C O   1 
ATOM 3592 C CB  . LEU C 3 2   ? 219.520 286.928 322.177 1.00 26.67  ? 2   LEU C CB  1 
ATOM 3593 C CG  . LEU C 3 2   ? 218.144 286.693 321.559 1.00 24.95  ? 2   LEU C CG  1 
ATOM 3594 C CD1 . LEU C 3 2   ? 218.153 286.982 320.076 1.00 28.52  ? 2   LEU C CD1 1 
ATOM 3595 C CD2 . LEU C 3 2   ? 217.702 285.272 321.823 1.00 20.22  ? 2   LEU C CD2 1 
ATOM 3596 N N   . PRO C 3 3   ? 218.453 290.211 322.208 1.00 32.29  ? 3   PRO C N   1 
ATOM 3597 C CA  . PRO C 3 3   ? 217.466 291.050 322.899 1.00 21.27  ? 3   PRO C CA  1 
ATOM 3598 C C   . PRO C 3 3   ? 216.257 290.242 323.346 1.00 22.49  ? 3   PRO C C   1 
ATOM 3599 O O   . PRO C 3 3   ? 215.752 289.394 322.610 1.00 24.79  ? 3   PRO C O   1 
ATOM 3600 C CB  . PRO C 3 3   ? 217.084 292.089 321.841 1.00 21.88  ? 3   PRO C CB  1 
ATOM 3601 C CG  . PRO C 3 3   ? 218.154 292.024 320.821 1.00 15.50  ? 3   PRO C CG  1 
ATOM 3602 C CD  . PRO C 3 3   ? 218.636 290.629 320.810 1.00 18.24  ? 3   PRO C CD  1 
ATOM 3603 N N   . VAL C 3 4   ? 215.789 290.518 324.562 1.00 22.69  ? 4   VAL C N   1 
ATOM 3604 C CA  . VAL C 3 4   ? 214.657 289.807 325.145 1.00 14.77  ? 4   VAL C CA  1 
ATOM 3605 C C   . VAL C 3 4   ? 213.818 290.781 325.958 1.00 20.87  ? 4   VAL C C   1 
ATOM 3606 O O   . VAL C 3 4   ? 214.317 291.793 326.455 1.00 25.95  ? 4   VAL C O   1 
ATOM 3607 C CB  . VAL C 3 4   ? 215.108 288.623 326.028 1.00 12.28  ? 4   VAL C CB  1 
ATOM 3608 C CG1 . VAL C 3 4   ? 215.963 287.663 325.229 1.00 20.40  ? 4   VAL C CG1 1 
ATOM 3609 C CG2 . VAL C 3 4   ? 215.851 289.119 327.247 1.00 18.72  ? 4   VAL C CG2 1 
ATOM 3610 N N   . MET C 3 5   ? 212.532 290.465 326.096 1.00 22.23  ? 5   MET C N   1 
ATOM 3611 C CA  . MET C 3 5   ? 211.595 291.286 326.849 1.00 31.43  ? 5   MET C CA  1 
ATOM 3612 C C   . MET C 3 5   ? 210.827 290.404 327.822 1.00 29.28  ? 5   MET C C   1 
ATOM 3613 O O   . MET C 3 5   ? 210.339 289.338 327.447 1.00 27.61  ? 5   MET C O   1 
ATOM 3614 C CB  . MET C 3 5   ? 210.619 292.009 325.913 1.00 30.43  ? 5   MET C CB  1 
ATOM 3615 C CG  . MET C 3 5   ? 210.055 293.300 326.468 1.00 26.34  ? 5   MET C CG  1 
ATOM 3616 S SD  . MET C 3 5   ? 208.504 293.760 325.687 1.00 46.94  ? 5   MET C SD  1 
ATOM 3617 C CE  . MET C 3 5   ? 208.903 293.481 323.967 1.00 38.97  ? 5   MET C CE  1 
ATOM 3618 N N   . ASN C 3 6   ? 210.715 290.855 329.066 1.00 28.74  ? 6   ASN C N   1 
ATOM 3619 C CA  . ASN C 3 6   ? 210.114 290.065 330.132 1.00 16.46  ? 6   ASN C CA  1 
ATOM 3620 C C   . ASN C 3 6   ? 208.620 290.339 330.202 1.00 22.57  ? 6   ASN C C   1 
ATOM 3621 O O   . ASN C 3 6   ? 208.203 291.457 330.518 1.00 40.02  ? 6   ASN C O   1 
ATOM 3622 C CB  . ASN C 3 6   ? 210.770 290.385 331.471 1.00 23.41  ? 6   ASN C CB  1 
ATOM 3623 C CG  . ASN C 3 6   ? 212.183 289.875 331.559 1.00 29.61  ? 6   ASN C CG  1 
ATOM 3624 O OD1 . ASN C 3 6   ? 212.760 289.440 330.569 1.00 33.64  ? 6   ASN C OD1 1 
ATOM 3625 N ND2 . ASN C 3 6   ? 212.752 289.928 332.751 1.00 36.32  ? 6   ASN C ND2 1 
ATOM 3626 N N   . THR C 3 7   ? 207.823 289.315 329.931 1.00 22.19  ? 7   THR C N   1 
ATOM 3627 C CA  . THR C 3 7   ? 206.378 289.423 329.948 1.00 25.24  ? 7   THR C CA  1 
ATOM 3628 C C   . THR C 3 7   ? 205.842 289.346 331.372 1.00 28.05  ? 7   THR C C   1 
ATOM 3629 O O   . THR C 3 7   ? 206.550 288.934 332.290 1.00 25.05  ? 7   THR C O   1 
ATOM 3630 C CB  . THR C 3 7   ? 205.765 288.310 329.112 1.00 16.60  ? 7   THR C CB  1 
ATOM 3631 O OG1 . THR C 3 7   ? 206.112 287.047 329.681 1.00 31.69  ? 7   THR C OG1 1 
ATOM 3632 C CG2 . THR C 3 7   ? 206.279 288.359 327.707 1.00 26.55  ? 7   THR C CG2 1 
ATOM 3633 N N   . PRO C 3 8   ? 204.595 289.758 331.588 1.00 30.61  ? 8   PRO C N   1 
ATOM 3634 C CA  . PRO C 3 8   ? 203.979 289.553 332.900 1.00 30.88  ? 8   PRO C CA  1 
ATOM 3635 C C   . PRO C 3 8   ? 203.864 288.073 333.228 1.00 32.03  ? 8   PRO C C   1 
ATOM 3636 O O   . PRO C 3 8   ? 203.642 287.235 332.353 1.00 33.32  ? 8   PRO C O   1 
ATOM 3637 C CB  . PRO C 3 8   ? 202.603 290.208 332.753 1.00 21.89  ? 8   PRO C CB  1 
ATOM 3638 C CG  . PRO C 3 8   ? 202.756 291.157 331.637 1.00 25.91  ? 8   PRO C CG  1 
ATOM 3639 C CD  . PRO C 3 8   ? 203.711 290.519 330.693 1.00 27.52  ? 8   PRO C CD  1 
ATOM 3640 N N   . GLY C 3 9   ? 204.014 287.758 334.510 1.00 21.34  ? 9   GLY C N   1 
ATOM 3641 C CA  . GLY C 3 9   ? 203.997 286.381 334.946 1.00 13.54  ? 9   GLY C CA  1 
ATOM 3642 C C   . GLY C 3 9   ? 205.358 285.737 335.030 1.00 30.95  ? 9   GLY C C   1 
ATOM 3643 O O   . GLY C 3 9   ? 205.475 284.531 334.801 1.00 29.70  ? 9   GLY C O   1 
ATOM 3644 N N   . SER C 3 10  ? 206.393 286.501 335.354 1.00 27.77  ? 10  SER C N   1 
ATOM 3645 C CA  . SER C 3 10  ? 207.746 285.990 335.477 1.00 17.21  ? 10  SER C CA  1 
ATOM 3646 C C   . SER C 3 10  ? 208.215 286.146 336.916 1.00 32.33  ? 10  SER C C   1 
ATOM 3647 O O   . SER C 3 10  ? 207.830 287.091 337.609 1.00 35.36  ? 10  SER C O   1 
ATOM 3648 C CB  . SER C 3 10  ? 208.693 286.723 334.531 1.00 22.71  ? 10  SER C CB  1 
ATOM 3649 O OG  . SER C 3 10  ? 208.675 288.111 334.785 1.00 34.76  ? 10  SER C OG  1 
ATOM 3650 N N   . ASN C 3 11  ? 209.054 285.207 337.359 1.00 26.31  ? 11  ASN C N   1 
ATOM 3651 C CA  . ASN C 3 11  ? 209.501 285.133 338.749 1.00 24.07  ? 11  ASN C CA  1 
ATOM 3652 C C   . ASN C 3 11  ? 208.335 284.889 339.698 1.00 26.59  ? 11  ASN C C   1 
ATOM 3653 O O   . ASN C 3 11  ? 208.322 285.390 340.823 1.00 30.87  ? 11  ASN C O   1 
ATOM 3654 C CB  . ASN C 3 11  ? 210.258 286.395 339.172 1.00 34.16  ? 11  ASN C CB  1 
ATOM 3655 C CG  . ASN C 3 11  ? 211.668 286.446 338.626 1.00 36.49  ? 11  ASN C CG  1 
ATOM 3656 O OD1 . ASN C 3 11  ? 211.997 285.779 337.650 1.00 39.50  ? 11  ASN C OD1 1 
ATOM 3657 N ND2 . ASN C 3 11  ? 212.510 287.240 339.262 1.00 37.55  ? 11  ASN C ND2 1 
ATOM 3658 N N   . GLN C 3 12  ? 207.344 284.125 339.253 1.00 28.89  ? 12  GLN C N   1 
ATOM 3659 C CA  . GLN C 3 12  ? 206.226 283.721 340.089 1.00 27.72  ? 12  GLN C CA  1 
ATOM 3660 C C   . GLN C 3 12  ? 206.183 282.206 340.168 1.00 25.86  ? 12  GLN C C   1 
ATOM 3661 O O   . GLN C 3 12  ? 206.621 281.512 339.249 1.00 33.92  ? 12  GLN C O   1 
ATOM 3662 C CB  . GLN C 3 12  ? 204.891 284.235 339.545 1.00 18.44  ? 12  GLN C CB  1 
ATOM 3663 C CG  . GLN C 3 12  ? 204.542 283.721 338.159 1.00 16.89  ? 12  GLN C CG  1 
ATOM 3664 C CD  . GLN C 3 12  ? 203.056 283.585 337.953 1.00 25.04  ? 12  GLN C CD  1 
ATOM 3665 O OE1 . GLN C 3 12  ? 202.266 284.035 338.774 1.00 32.69  ? 12  GLN C OE1 1 
ATOM 3666 N NE2 . GLN C 3 12  ? 202.665 282.957 336.855 1.00 25.60  ? 12  GLN C NE2 1 
ATOM 3667 N N   . TYR C 3 13  ? 205.639 281.698 341.262 1.00 20.60  ? 13  TYR C N   1 
ATOM 3668 C CA  . TYR C 3 13  ? 205.476 280.265 341.456 1.00 13.45  ? 13  TYR C CA  1 
ATOM 3669 C C   . TYR C 3 13  ? 203.992 279.931 341.379 1.00 28.95  ? 13  TYR C C   1 
ATOM 3670 O O   . TYR C 3 13  ? 203.212 280.330 342.248 1.00 32.51  ? 13  TYR C O   1 
ATOM 3671 C CB  . TYR C 3 13  ? 206.083 279.819 342.784 1.00 7.45   ? 13  TYR C CB  1 
ATOM 3672 C CG  . TYR C 3 13  ? 205.779 278.383 343.111 1.00 21.70  ? 13  TYR C CG  1 
ATOM 3673 C CD1 . TYR C 3 13  ? 205.973 277.386 342.171 1.00 21.00  ? 13  TYR C CD1 1 
ATOM 3674 C CD2 . TYR C 3 13  ? 205.288 278.023 344.354 1.00 23.00  ? 13  TYR C CD2 1 
ATOM 3675 C CE1 . TYR C 3 13  ? 205.685 276.081 342.459 1.00 22.11  ? 13  TYR C CE1 1 
ATOM 3676 C CE2 . TYR C 3 13  ? 205.005 276.719 344.648 1.00 16.16  ? 13  TYR C CE2 1 
ATOM 3677 C CZ  . TYR C 3 13  ? 205.201 275.753 343.699 1.00 23.10  ? 13  TYR C CZ  1 
ATOM 3678 O OH  . TYR C 3 13  ? 204.917 274.444 343.994 1.00 28.33  ? 13  TYR C OH  1 
ATOM 3679 N N   . LEU C 3 14  ? 203.607 279.209 340.335 1.00 28.07  ? 14  LEU C N   1 
ATOM 3680 C CA  . LEU C 3 14  ? 202.259 278.681 340.189 1.00 20.58  ? 14  LEU C CA  1 
ATOM 3681 C C   . LEU C 3 14  ? 202.296 277.195 340.513 1.00 26.58  ? 14  LEU C C   1 
ATOM 3682 O O   . LEU C 3 14  ? 202.994 276.431 339.841 1.00 33.02  ? 14  LEU C O   1 
ATOM 3683 C CB  . LEU C 3 14  ? 201.735 278.916 338.773 1.00 28.34  ? 14  LEU C CB  1 
ATOM 3684 C CG  . LEU C 3 14  ? 200.365 278.326 338.438 1.00 32.74  ? 14  LEU C CG  1 
ATOM 3685 C CD1 . LEU C 3 14  ? 199.278 278.993 339.256 1.00 35.91  ? 14  LEU C CD1 1 
ATOM 3686 C CD2 . LEU C 3 14  ? 200.070 278.442 336.959 1.00 31.89  ? 14  LEU C CD2 1 
ATOM 3687 N N   . THR C 3 15  ? 201.541 276.784 341.524 1.00 30.42  ? 15  THR C N   1 
ATOM 3688 C CA  . THR C 3 15  ? 201.611 275.401 341.998 1.00 20.66  ? 15  THR C CA  1 
ATOM 3689 C C   . THR C 3 15  ? 201.051 274.407 341.007 1.00 22.68  ? 15  THR C C   1 
ATOM 3690 O O   . THR C 3 15  ? 200.989 273.226 341.339 1.00 35.00  ? 15  THR C O   1 
ATOM 3691 C CB  . THR C 3 15  ? 200.880 275.253 343.334 1.00 15.09  ? 15  THR C CB  1 
ATOM 3692 O OG1 . THR C 3 15  ? 199.472 275.395 343.134 1.00 35.51  ? 15  THR C OG1 1 
ATOM 3693 C CG2 . THR C 3 15  ? 201.338 276.298 344.326 1.00 21.52  ? 15  THR C CG2 1 
ATOM 3694 N N   . ALA C 3 16  ? 200.651 274.819 339.807 1.00 31.32  ? 16  ALA C N   1 
ATOM 3695 C CA  . ALA C 3 16  ? 200.094 273.918 338.806 1.00 27.49  ? 16  ALA C CA  1 
ATOM 3696 C C   . ALA C 3 16  ? 200.879 273.950 337.500 1.00 32.80  ? 16  ALA C C   1 
ATOM 3697 O O   . ALA C 3 16  ? 200.351 273.558 336.457 1.00 35.64  ? 16  ALA C O   1 
ATOM 3698 C CB  . ALA C 3 16  ? 198.629 274.264 338.547 1.00 21.29  ? 16  ALA C CB  1 
ATOM 3699 N N   . ASP C 3 17  ? 202.130 274.396 337.534 1.00 33.94  ? 17  ASP C N   1 
ATOM 3700 C CA  . ASP C 3 17  ? 202.935 274.533 336.330 1.00 38.43  ? 17  ASP C CA  1 
ATOM 3701 C C   . ASP C 3 17  ? 203.742 273.268 336.069 1.00 40.48  ? 17  ASP C C   1 
ATOM 3702 O O   . ASP C 3 17  ? 203.967 272.447 336.960 1.00 47.35  ? 17  ASP C O   1 
ATOM 3703 C CB  . ASP C 3 17  ? 203.870 275.735 336.442 1.00 41.35  ? 17  ASP C CB  1 
ATOM 3704 C CG  . ASP C 3 17  ? 204.844 275.611 337.589 1.00 42.31  ? 17  ASP C CG  1 
ATOM 3705 O OD1 . ASP C 3 17  ? 204.784 274.599 338.311 1.00 41.94  ? 17  ASP C OD1 1 
ATOM 3706 O OD2 . ASP C 3 17  ? 205.670 276.527 337.770 1.00 46.78  ? 17  ASP C OD2 1 
ATOM 3707 N N   . ASN C 3 18  ? 204.191 273.127 334.823 1.00 38.88  ? 18  ASN C N   1 
ATOM 3708 C CA  . ASN C 3 18  ? 204.878 271.925 334.349 1.00 37.24  ? 18  ASN C CA  1 
ATOM 3709 C C   . ASN C 3 18  ? 206.158 272.355 333.635 1.00 43.86  ? 18  ASN C C   1 
ATOM 3710 O O   . ASN C 3 18  ? 206.197 272.441 332.408 1.00 47.38  ? 18  ASN C O   1 
ATOM 3711 C CB  . ASN C 3 18  ? 203.954 271.123 333.440 1.00 38.47  ? 18  ASN C CB  1 
ATOM 3712 C CG  . ASN C 3 18  ? 204.602 269.873 332.905 1.00 49.41  ? 18  ASN C CG  1 
ATOM 3713 O OD1 . ASN C 3 18  ? 205.547 269.352 333.491 1.00 55.02  ? 18  ASN C OD1 1 
ATOM 3714 N ND2 . ASN C 3 18  ? 204.096 269.380 331.781 1.00 45.61  ? 18  ASN C ND2 1 
ATOM 3715 N N   . PHE C 3 19  ? 207.213 272.597 334.410 1.00 41.27  ? 19  PHE C N   1 
ATOM 3716 C CA  . PHE C 3 19  ? 208.484 273.081 333.888 1.00 41.37  ? 19  PHE C CA  1 
ATOM 3717 C C   . PHE C 3 19  ? 209.602 272.106 334.227 1.00 47.60  ? 19  PHE C C   1 
ATOM 3718 O O   . PHE C 3 19  ? 209.575 271.440 335.265 1.00 54.38  ? 19  PHE C O   1 
ATOM 3719 C CB  . PHE C 3 19  ? 208.843 274.458 334.464 1.00 34.79  ? 19  PHE C CB  1 
ATOM 3720 C CG  . PHE C 3 19  ? 207.963 275.570 333.986 1.00 36.69  ? 19  PHE C CG  1 
ATOM 3721 C CD1 . PHE C 3 19  ? 207.548 275.635 332.673 1.00 36.72  ? 19  PHE C CD1 1 
ATOM 3722 C CD2 . PHE C 3 19  ? 207.555 276.559 334.858 1.00 32.52  ? 19  PHE C CD2 1 
ATOM 3723 C CE1 . PHE C 3 19  ? 206.746 276.658 332.241 1.00 36.51  ? 19  PHE C CE1 1 
ATOM 3724 C CE2 . PHE C 3 19  ? 206.751 277.584 334.432 1.00 35.40  ? 19  PHE C CE2 1 
ATOM 3725 C CZ  . PHE C 3 19  ? 206.345 277.636 333.122 1.00 40.28  ? 19  PHE C CZ  1 
ATOM 3726 N N   . GLN C 3 20  ? 210.591 272.032 333.341 1.00 58.97  ? 20  GLN C N   1 
ATOM 3727 C CA  . GLN C 3 20  ? 211.788 271.257 333.630 1.00 57.13  ? 20  GLN C CA  1 
ATOM 3728 C C   . GLN C 3 20  ? 212.565 271.902 334.766 1.00 56.83  ? 20  GLN C C   1 
ATOM 3729 O O   . GLN C 3 20  ? 212.682 273.127 334.845 1.00 56.73  ? 20  GLN C O   1 
ATOM 3730 C CB  . GLN C 3 20  ? 212.674 271.152 332.393 1.00 58.53  ? 20  GLN C CB  1 
ATOM 3731 C CG  . GLN C 3 20  ? 211.966 270.605 331.176 1.00 64.08  ? 20  GLN C CG  1 
ATOM 3732 C CD  . GLN C 3 20  ? 212.879 270.505 329.978 1.00 67.45  ? 20  GLN C CD  1 
ATOM 3733 O OE1 . GLN C 3 20  ? 213.992 269.990 330.075 1.00 68.44  ? 20  GLN C OE1 1 
ATOM 3734 N NE2 . GLN C 3 20  ? 212.417 271.003 328.838 1.00 65.47  ? 20  GLN C NE2 1 
ATOM 3735 N N   . SER C 3 21  ? 213.112 271.068 335.636 1.00 53.90  ? 21  SER C N   1 
ATOM 3736 C CA  . SER C 3 21  ? 213.826 271.489 336.826 1.00 47.27  ? 21  SER C CA  1 
ATOM 3737 C C   . SER C 3 21  ? 215.214 270.867 336.845 1.00 49.99  ? 21  SER C C   1 
ATOM 3738 O O   . SER C 3 21  ? 215.463 269.865 336.166 1.00 51.94  ? 21  SER C O   1 
ATOM 3739 C CB  . SER C 3 21  ? 213.057 271.080 338.087 1.00 47.89  ? 21  SER C CB  1 
ATOM 3740 O OG  . SER C 3 21  ? 212.760 269.698 338.057 1.00 53.55  ? 21  SER C OG  1 
ATOM 3741 N N   . PRO C 3 22  ? 216.152 271.451 337.591 1.00 48.24  ? 22  PRO C N   1 
ATOM 3742 C CA  . PRO C 3 22  ? 217.507 270.886 337.654 1.00 38.96  ? 22  PRO C CA  1 
ATOM 3743 C C   . PRO C 3 22  ? 217.562 269.681 338.583 1.00 37.90  ? 22  PRO C C   1 
ATOM 3744 O O   . PRO C 3 22  ? 217.060 269.725 339.706 1.00 39.32  ? 22  PRO C O   1 
ATOM 3745 C CB  . PRO C 3 22  ? 218.346 272.046 338.193 1.00 41.82  ? 22  PRO C CB  1 
ATOM 3746 C CG  . PRO C 3 22  ? 217.386 272.833 339.016 1.00 44.38  ? 22  PRO C CG  1 
ATOM 3747 C CD  . PRO C 3 22  ? 216.053 272.721 338.331 1.00 43.48  ? 22  PRO C CD  1 
ATOM 3748 N N   . CYS C 3 23  ? 218.187 268.606 338.109 1.00 46.01  ? 23  CYS C N   1 
ATOM 3749 C CA  . CYS C 3 23  ? 218.327 267.400 338.913 1.00 45.53  ? 23  CYS C CA  1 
ATOM 3750 C C   . CYS C 3 23  ? 219.361 267.603 340.012 1.00 39.91  ? 23  CYS C C   1 
ATOM 3751 O O   . CYS C 3 23  ? 220.396 268.239 339.803 1.00 43.46  ? 23  CYS C O   1 
ATOM 3752 C CB  . CYS C 3 23  ? 218.730 266.219 338.033 1.00 43.35  ? 23  CYS C CB  1 
ATOM 3753 S SG  . CYS C 3 23  ? 218.543 264.611 338.831 1.00 54.27  ? 23  CYS C SG  1 
ATOM 3754 N N   . ALA C 3 24  ? 219.081 267.046 341.188 1.00 32.34  ? 24  ALA C N   1 
ATOM 3755 C CA  . ALA C 3 24  ? 219.959 267.214 342.338 1.00 38.16  ? 24  ALA C CA  1 
ATOM 3756 C C   . ALA C 3 24  ? 220.981 266.098 342.475 1.00 31.80  ? 24  ALA C C   1 
ATOM 3757 O O   . ALA C 3 24  ? 222.053 266.322 343.045 1.00 37.76  ? 24  ALA C O   1 
ATOM 3758 C CB  . ALA C 3 24  ? 219.134 267.293 343.623 1.00 40.35  ? 24  ALA C CB  1 
ATOM 3759 N N   . LEU C 3 25  ? 220.683 264.908 341.963 1.00 35.38  ? 25  LEU C N   1 
ATOM 3760 C CA  . LEU C 3 25  ? 221.576 263.754 342.047 1.00 28.71  ? 25  LEU C CA  1 
ATOM 3761 C C   . LEU C 3 25  ? 221.801 263.210 340.646 1.00 29.90  ? 25  LEU C C   1 
ATOM 3762 O O   . LEU C 3 25  ? 221.365 262.103 340.317 1.00 32.10  ? 25  LEU C O   1 
ATOM 3763 C CB  . LEU C 3 25  ? 221.005 262.663 342.954 1.00 26.57  ? 25  LEU C CB  1 
ATOM 3764 C CG  . LEU C 3 25  ? 220.965 262.905 344.460 1.00 31.58  ? 25  LEU C CG  1 
ATOM 3765 C CD1 . LEU C 3 25  ? 220.359 261.700 345.151 1.00 34.86  ? 25  LEU C CD1 1 
ATOM 3766 C CD2 . LEU C 3 25  ? 222.349 263.197 345.007 1.00 29.79  ? 25  LEU C CD2 1 
ATOM 3767 N N   . PRO C 3 26  ? 222.488 263.958 339.799 1.00 35.52  ? 26  PRO C N   1 
ATOM 3768 C CA  . PRO C 3 26  ? 222.851 263.416 338.486 1.00 41.30  ? 26  PRO C CA  1 
ATOM 3769 C C   . PRO C 3 26  ? 223.802 262.245 338.643 1.00 43.91  ? 26  PRO C C   1 
ATOM 3770 O O   . PRO C 3 26  ? 224.143 261.880 339.772 1.00 48.58  ? 26  PRO C O   1 
ATOM 3771 C CB  . PRO C 3 26  ? 223.513 264.605 337.783 1.00 40.08  ? 26  PRO C CB  1 
ATOM 3772 C CG  . PRO C 3 26  ? 223.955 265.494 338.872 1.00 38.76  ? 26  PRO C CG  1 
ATOM 3773 C CD  . PRO C 3 26  ? 222.989 265.326 339.990 1.00 38.35  ? 26  PRO C CD  1 
ATOM 3774 N N   . GLU C 3 27  ? 224.234 261.646 337.535 1.00 47.41  ? 27  GLU C N   1 
ATOM 3775 C CA  . GLU C 3 27  ? 225.211 260.558 337.573 1.00 55.81  ? 27  GLU C CA  1 
ATOM 3776 C C   . GLU C 3 27  ? 224.854 259.536 338.651 1.00 55.06  ? 27  GLU C C   1 
ATOM 3777 O O   . GLU C 3 27  ? 225.715 259.031 339.371 1.00 51.75  ? 27  GLU C O   1 
ATOM 3778 C CB  . GLU C 3 27  ? 226.627 261.100 337.786 1.00 48.83  ? 27  GLU C CB  1 
ATOM 3779 C CG  . GLU C 3 27  ? 226.829 261.849 339.096 1.00 50.10  ? 27  GLU C CG  1 
ATOM 3780 C CD  . GLU C 3 27  ? 228.248 262.310 339.287 1.00 59.76  ? 27  GLU C CD  1 
ATOM 3781 O OE1 . GLU C 3 27  ? 229.071 262.056 338.386 1.00 69.12  ? 27  GLU C OE1 1 
ATOM 3782 O OE2 . GLU C 3 27  ? 228.539 262.931 340.332 1.00 54.21  ? 27  GLU C OE2 1 
ATOM 3783 N N   . PHE C 3 28  ? 223.563 259.238 338.762 1.00 50.41  ? 28  PHE C N   1 
ATOM 3784 C CA  . PHE C 3 28  ? 223.039 258.271 339.715 1.00 34.75  ? 28  PHE C CA  1 
ATOM 3785 C C   . PHE C 3 28  ? 222.176 257.285 338.951 1.00 39.26  ? 28  PHE C C   1 
ATOM 3786 O O   . PHE C 3 28  ? 221.362 257.690 338.117 1.00 42.09  ? 28  PHE C O   1 
ATOM 3787 C CB  . PHE C 3 28  ? 222.226 258.964 340.810 1.00 35.03  ? 28  PHE C CB  1 
ATOM 3788 C CG  . PHE C 3 28  ? 221.571 258.024 341.771 1.00 37.33  ? 28  PHE C CG  1 
ATOM 3789 C CD1 . PHE C 3 28  ? 220.336 257.475 341.490 1.00 40.01  ? 28  PHE C CD1 1 
ATOM 3790 C CD2 . PHE C 3 28  ? 222.178 257.703 342.966 1.00 41.89  ? 28  PHE C CD2 1 
ATOM 3791 C CE1 . PHE C 3 28  ? 219.728 256.617 342.373 1.00 39.14  ? 28  PHE C CE1 1 
ATOM 3792 C CE2 . PHE C 3 28  ? 221.572 256.844 343.853 1.00 41.88  ? 28  PHE C CE2 1 
ATOM 3793 C CZ  . PHE C 3 28  ? 220.345 256.301 343.556 1.00 40.10  ? 28  PHE C CZ  1 
ATOM 3794 N N   . ASP C 3 29  ? 222.361 255.999 339.224 1.00 53.97  ? 29  ASP C N   1 
ATOM 3795 C CA  . ASP C 3 29  ? 221.647 254.939 338.526 1.00 51.51  ? 29  ASP C CA  1 
ATOM 3796 C C   . ASP C 3 29  ? 220.536 254.408 339.418 1.00 51.19  ? 29  ASP C C   1 
ATOM 3797 O O   . ASP C 3 29  ? 220.792 253.986 340.549 1.00 52.56  ? 29  ASP C O   1 
ATOM 3798 C CB  . ASP C 3 29  ? 222.603 253.812 338.138 1.00 47.76  ? 29  ASP C CB  1 
ATOM 3799 C CG  . ASP C 3 29  ? 222.133 253.037 336.926 1.00 57.06  ? 29  ASP C CG  1 
ATOM 3800 O OD1 . ASP C 3 29  ? 221.129 253.445 336.308 1.00 56.00  ? 29  ASP C OD1 1 
ATOM 3801 O OD2 . ASP C 3 29  ? 222.767 252.016 336.590 1.00 64.06  ? 29  ASP C OD2 1 
ATOM 3802 N N   . VAL C 3 30  ? 219.314 254.423 338.909 1.00 45.49  ? 30  VAL C N   1 
ATOM 3803 C CA  . VAL C 3 30  ? 218.143 254.051 339.694 1.00 46.13  ? 30  VAL C CA  1 
ATOM 3804 C C   . VAL C 3 30  ? 217.883 252.559 339.549 1.00 43.19  ? 30  VAL C C   1 
ATOM 3805 O O   . VAL C 3 30  ? 218.175 251.946 338.518 1.00 45.56  ? 30  VAL C O   1 
ATOM 3806 C CB  . VAL C 3 30  ? 216.908 254.877 339.277 1.00 39.51  ? 30  VAL C CB  1 
ATOM 3807 C CG1 . VAL C 3 30  ? 217.155 256.350 339.518 1.00 37.00  ? 30  VAL C CG1 1 
ATOM 3808 C CG2 . VAL C 3 30  ? 216.549 254.621 337.821 1.00 43.13  ? 30  VAL C CG2 1 
ATOM 3809 N N   . THR C 3 31  ? 217.317 251.974 340.594 1.00 38.74  ? 31  THR C N   1 
ATOM 3810 C CA  . THR C 3 31  ? 216.957 250.566 340.575 1.00 32.19  ? 31  THR C CA  1 
ATOM 3811 C C   . THR C 3 31  ? 215.884 250.343 339.520 1.00 41.73  ? 31  THR C C   1 
ATOM 3812 O O   . THR C 3 31  ? 214.816 250.962 339.603 1.00 50.89  ? 31  THR C O   1 
ATOM 3813 C CB  . THR C 3 31  ? 216.443 250.142 341.944 1.00 36.67  ? 31  THR C CB  1 
ATOM 3814 O OG1 . THR C 3 31  ? 217.277 250.698 342.965 1.00 37.19  ? 31  THR C OG1 1 
ATOM 3815 C CG2 . THR C 3 31  ? 216.433 248.638 342.072 1.00 40.26  ? 31  THR C CG2 1 
ATOM 3816 N N   . PRO C 3 32  ? 216.101 249.479 338.528 1.00 34.30  ? 32  PRO C N   1 
ATOM 3817 C CA  . PRO C 3 32  ? 215.110 249.336 337.468 1.00 45.05  ? 32  PRO C CA  1 
ATOM 3818 C C   . PRO C 3 32  ? 213.829 248.726 338.006 1.00 49.49  ? 32  PRO C C   1 
ATOM 3819 O O   . PRO C 3 32  ? 213.855 247.953 338.978 1.00 52.54  ? 32  PRO C O   1 
ATOM 3820 C CB  . PRO C 3 32  ? 215.802 248.402 336.461 1.00 46.66  ? 32  PRO C CB  1 
ATOM 3821 C CG  . PRO C 3 32  ? 216.748 247.624 337.278 1.00 46.13  ? 32  PRO C CG  1 
ATOM 3822 C CD  . PRO C 3 32  ? 217.219 248.536 338.365 1.00 40.97  ? 32  PRO C CD  1 
ATOM 3823 N N   . PRO C 3 33  ? 212.682 249.051 337.416 1.00 47.56  ? 33  PRO C N   1 
ATOM 3824 C CA  . PRO C 3 33  ? 211.425 248.456 337.876 1.00 41.95  ? 33  PRO C CA  1 
ATOM 3825 C C   . PRO C 3 33  ? 211.253 247.028 337.383 1.00 49.87  ? 33  PRO C C   1 
ATOM 3826 O O   . PRO C 3 33  ? 211.753 246.642 336.325 1.00 48.60  ? 33  PRO C O   1 
ATOM 3827 C CB  . PRO C 3 33  ? 210.364 249.380 337.272 1.00 40.96  ? 33  PRO C CB  1 
ATOM 3828 C CG  . PRO C 3 33  ? 210.992 249.885 336.033 1.00 40.91  ? 33  PRO C CG  1 
ATOM 3829 C CD  . PRO C 3 33  ? 212.460 250.015 336.324 1.00 43.34  ? 33  PRO C CD  1 
ATOM 3830 N N   . ILE C 3 34  ? 210.521 246.245 338.170 1.00 58.65  ? 34  ILE C N   1 
ATOM 3831 C CA  . ILE C 3 34  ? 210.234 244.856 337.842 1.00 48.74  ? 34  ILE C CA  1 
ATOM 3832 C C   . ILE C 3 34  ? 208.760 244.734 337.472 1.00 50.35  ? 34  ILE C C   1 
ATOM 3833 O O   . ILE C 3 34  ? 207.966 245.655 337.661 1.00 53.00  ? 34  ILE C O   1 
ATOM 3834 C CB  . ILE C 3 34  ? 210.597 243.896 338.992 1.00 44.07  ? 34  ILE C CB  1 
ATOM 3835 C CG1 . ILE C 3 34  ? 209.876 244.301 340.278 1.00 47.25  ? 34  ILE C CG1 1 
ATOM 3836 C CG2 . ILE C 3 34  ? 212.091 243.879 339.204 1.00 50.88  ? 34  ILE C CG2 1 
ATOM 3837 C CD1 . ILE C 3 34  ? 210.037 243.313 341.402 1.00 48.76  ? 34  ILE C CD1 1 
ATOM 3838 N N   . ASP C 3 35  ? 208.396 243.569 336.941 1.00 58.22  ? 35  ASP C N   1 
ATOM 3839 C CA  . ASP C 3 35  ? 207.042 243.334 336.444 1.00 55.42  ? 35  ASP C CA  1 
ATOM 3840 C C   . ASP C 3 35  ? 206.158 242.812 337.577 1.00 52.71  ? 35  ASP C C   1 
ATOM 3841 O O   . ASP C 3 35  ? 205.816 241.632 337.659 1.00 52.96  ? 35  ASP C O   1 
ATOM 3842 C CB  . ASP C 3 35  ? 207.076 242.370 335.267 1.00 53.72  ? 35  ASP C CB  1 
ATOM 3843 C CG  . ASP C 3 35  ? 205.805 242.408 334.447 1.00 60.69  ? 35  ASP C CG  1 
ATOM 3844 O OD1 . ASP C 3 35  ? 204.766 242.846 334.982 1.00 61.16  ? 35  ASP C OD1 1 
ATOM 3845 O OD2 . ASP C 3 35  ? 205.844 242.003 333.267 1.00 64.17  ? 35  ASP C OD2 1 
ATOM 3846 N N   . ILE C 3 36  ? 205.789 243.726 338.465 1.00 38.79  ? 36  ILE C N   1 
ATOM 3847 C CA  . ILE C 3 36  ? 204.838 243.384 339.529 1.00 44.60  ? 36  ILE C CA  1 
ATOM 3848 C C   . ILE C 3 36  ? 203.461 243.179 338.908 1.00 43.81  ? 36  ILE C C   1 
ATOM 3849 O O   . ILE C 3 36  ? 203.117 243.883 337.945 1.00 50.39  ? 36  ILE C O   1 
ATOM 3850 C CB  . ILE C 3 36  ? 204.810 244.484 340.592 1.00 48.95  ? 36  ILE C CB  1 
ATOM 3851 C CG1 . ILE C 3 36  ? 206.232 244.851 341.029 1.00 38.65  ? 36  ILE C CG1 1 
ATOM 3852 C CG2 . ILE C 3 36  ? 203.989 244.036 341.792 1.00 44.78  ? 36  ILE C CG2 1 
ATOM 3853 C CD1 . ILE C 3 36  ? 206.293 245.898 342.115 1.00 36.68  ? 36  ILE C CD1 1 
ATOM 3854 N N   . PRO C 3 37  ? 202.642 242.236 339.397 1.00 44.41  ? 37  PRO C N   1 
ATOM 3855 C CA  . PRO C 3 37  ? 201.425 241.873 338.654 1.00 50.64  ? 37  PRO C CA  1 
ATOM 3856 C C   . PRO C 3 37  ? 200.363 242.959 338.520 1.00 55.25  ? 37  PRO C C   1 
ATOM 3857 O O   . PRO C 3 37  ? 200.013 243.325 337.394 1.00 57.37  ? 37  PRO C O   1 
ATOM 3858 C CB  . PRO C 3 37  ? 200.884 240.678 339.449 1.00 53.78  ? 37  PRO C CB  1 
ATOM 3859 C CG  . PRO C 3 37  ? 202.051 240.130 340.151 1.00 52.47  ? 37  PRO C CG  1 
ATOM 3860 C CD  . PRO C 3 37  ? 202.872 241.316 340.522 1.00 50.80  ? 37  PRO C CD  1 
ATOM 3861 N N   . GLY C 3 38  ? 199.835 243.484 339.625 1.00 44.36  ? 38  GLY C N   1 
ATOM 3862 C CA  . GLY C 3 38  ? 198.614 244.269 339.545 1.00 41.56  ? 38  GLY C CA  1 
ATOM 3863 C C   . GLY C 3 38  ? 198.791 245.764 339.378 1.00 42.41  ? 38  GLY C C   1 
ATOM 3864 O O   . GLY C 3 38  ? 198.860 246.495 340.369 1.00 38.39  ? 38  GLY C O   1 
ATOM 3865 N N   . GLU C 3 39  ? 198.796 246.240 338.135 1.00 46.39  ? 39  GLU C N   1 
ATOM 3866 C CA  . GLU C 3 39  ? 199.100 247.631 337.824 1.00 42.11  ? 39  GLU C CA  1 
ATOM 3867 C C   . GLU C 3 39  ? 197.819 248.405 337.552 1.00 45.18  ? 39  GLU C C   1 
ATOM 3868 O O   . GLU C 3 39  ? 197.015 248.004 336.708 1.00 48.83  ? 39  GLU C O   1 
ATOM 3869 C CB  . GLU C 3 39  ? 200.019 247.728 336.607 1.00 41.67  ? 39  GLU C CB  1 
ATOM 3870 C CG  . GLU C 3 39  ? 201.293 248.517 336.841 1.00 49.40  ? 39  GLU C CG  1 
ATOM 3871 C CD  . GLU C 3 39  ? 201.462 249.673 335.884 1.00 52.27  ? 39  GLU C CD  1 
ATOM 3872 O OE1 . GLU C 3 39  ? 201.293 249.469 334.666 1.00 52.76  ? 39  GLU C OE1 1 
ATOM 3873 O OE2 . GLU C 3 39  ? 201.766 250.787 336.353 1.00 50.24  ? 39  GLU C OE2 1 
ATOM 3874 N N   . VAL C 3 40  ? 197.651 249.525 338.247 1.00 46.21  ? 40  VAL C N   1 
ATOM 3875 C CA  . VAL C 3 40  ? 196.489 250.391 338.097 1.00 44.53  ? 40  VAL C CA  1 
ATOM 3876 C C   . VAL C 3 40  ? 196.916 251.627 337.320 1.00 38.97  ? 40  VAL C C   1 
ATOM 3877 O O   . VAL C 3 40  ? 197.851 252.328 337.721 1.00 49.34  ? 40  VAL C O   1 
ATOM 3878 C CB  . VAL C 3 40  ? 195.905 250.775 339.464 1.00 43.30  ? 40  VAL C CB  1 
ATOM 3879 C CG1 . VAL C 3 40  ? 194.679 251.650 339.295 1.00 42.18  ? 40  VAL C CG1 1 
ATOM 3880 C CG2 . VAL C 3 40  ? 195.570 249.531 340.258 1.00 42.12  ? 40  VAL C CG2 1 
ATOM 3881 N N   . LYS C 3 41  ? 196.233 251.900 336.211 1.00 39.60  ? 41  LYS C N   1 
ATOM 3882 C CA  . LYS C 3 41  ? 196.560 253.033 335.356 1.00 44.44  ? 41  LYS C CA  1 
ATOM 3883 C C   . LYS C 3 41  ? 195.498 254.123 335.360 1.00 39.96  ? 41  LYS C C   1 
ATOM 3884 O O   . LYS C 3 41  ? 195.737 255.196 334.802 1.00 35.53  ? 41  LYS C O   1 
ATOM 3885 C CB  . LYS C 3 41  ? 196.787 252.553 333.922 1.00 39.25  ? 41  LYS C CB  1 
ATOM 3886 C CG  . LYS C 3 41  ? 197.988 251.647 333.792 1.00 40.55  ? 41  LYS C CG  1 
ATOM 3887 C CD  . LYS C 3 41  ? 197.888 250.754 332.578 1.00 44.95  ? 41  LYS C CD  1 
ATOM 3888 C CE  . LYS C 3 41  ? 198.998 249.726 332.573 1.00 50.25  ? 41  LYS C CE  1 
ATOM 3889 N NZ  . LYS C 3 41  ? 200.335 250.372 332.577 1.00 52.36  ? 41  LYS C NZ  1 
ATOM 3890 N N   . ASN C 3 42  ? 194.340 253.878 335.963 1.00 40.37  ? 42  ASN C N   1 
ATOM 3891 C CA  . ASN C 3 42  ? 193.305 254.892 336.062 1.00 31.91  ? 42  ASN C CA  1 
ATOM 3892 C C   . ASN C 3 42  ? 192.444 254.575 337.271 1.00 30.34  ? 42  ASN C C   1 
ATOM 3893 O O   . ASN C 3 42  ? 192.239 253.410 337.610 1.00 42.15  ? 42  ASN C O   1 
ATOM 3894 C CB  . ASN C 3 42  ? 192.457 254.947 334.790 1.00 34.18  ? 42  ASN C CB  1 
ATOM 3895 C CG  . ASN C 3 42  ? 191.518 256.128 334.770 1.00 44.14  ? 42  ASN C CG  1 
ATOM 3896 O OD1 . ASN C 3 42  ? 190.812 256.391 335.739 1.00 49.61  ? 42  ASN C OD1 1 
ATOM 3897 N ND2 . ASN C 3 42  ? 191.515 256.858 333.666 1.00 39.63  ? 42  ASN C ND2 1 
ATOM 3898 N N   . MET C 3 43  ? 191.948 255.622 337.924 1.00 30.15  ? 43  MET C N   1 
ATOM 3899 C CA  . MET C 3 43  ? 191.137 255.444 339.120 1.00 34.20  ? 43  MET C CA  1 
ATOM 3900 C C   . MET C 3 43  ? 189.707 255.022 338.817 1.00 37.18  ? 43  MET C C   1 
ATOM 3901 O O   . MET C 3 43  ? 188.975 254.681 339.747 1.00 31.40  ? 43  MET C O   1 
ATOM 3902 C CB  . MET C 3 43  ? 191.120 256.733 339.939 1.00 29.24  ? 43  MET C CB  1 
ATOM 3903 C CG  . MET C 3 43  ? 192.487 257.171 340.395 1.00 35.40  ? 43  MET C CG  1 
ATOM 3904 S SD  . MET C 3 43  ? 193.309 255.959 341.435 1.00 68.45  ? 43  MET C SD  1 
ATOM 3905 C CE  . MET C 3 43  ? 192.237 255.960 342.864 1.00 39.96  ? 43  MET C CE  1 
ATOM 3906 N N   . MET C 3 44  ? 189.283 255.064 337.556 1.00 46.89  ? 44  MET C N   1 
ATOM 3907 C CA  . MET C 3 44  ? 187.978 254.523 337.204 1.00 46.53  ? 44  MET C CA  1 
ATOM 3908 C C   . MET C 3 44  ? 187.997 253.004 337.180 1.00 48.85  ? 44  MET C C   1 
ATOM 3909 O O   . MET C 3 44  ? 186.965 252.372 337.424 1.00 51.37  ? 44  MET C O   1 
ATOM 3910 C CB  . MET C 3 44  ? 187.527 255.066 335.848 1.00 43.29  ? 44  MET C CB  1 
ATOM 3911 C CG  . MET C 3 44  ? 187.005 256.498 335.888 1.00 44.07  ? 44  MET C CG  1 
ATOM 3912 S SD  . MET C 3 44  ? 185.476 256.676 336.821 1.00 47.48  ? 44  MET C SD  1 
ATOM 3913 C CE  . MET C 3 44  ? 186.089 257.119 338.440 1.00 46.39  ? 44  MET C CE  1 
ATOM 3914 N N   . GLU C 3 45  ? 189.158 252.407 336.912 1.00 48.64  ? 45  GLU C N   1 
ATOM 3915 C CA  . GLU C 3 45  ? 189.292 250.960 336.991 1.00 43.24  ? 45  GLU C CA  1 
ATOM 3916 C C   . GLU C 3 45  ? 188.980 250.433 338.382 1.00 45.59  ? 45  GLU C C   1 
ATOM 3917 O O   . GLU C 3 45  ? 188.673 249.247 338.526 1.00 51.99  ? 45  GLU C O   1 
ATOM 3918 C CB  . GLU C 3 45  ? 190.705 250.548 336.589 1.00 46.74  ? 45  GLU C CB  1 
ATOM 3919 C CG  . GLU C 3 45  ? 191.066 250.897 335.158 1.00 51.89  ? 45  GLU C CG  1 
ATOM 3920 C CD  . GLU C 3 45  ? 192.527 250.642 334.847 1.00 58.99  ? 45  GLU C CD  1 
ATOM 3921 O OE1 . GLU C 3 45  ? 193.292 250.348 335.788 1.00 53.91  ? 45  GLU C OE1 1 
ATOM 3922 O OE2 . GLU C 3 45  ? 192.913 250.737 333.663 1.00 60.10  ? 45  GLU C OE2 1 
ATOM 3923 N N   . LEU C 3 46  ? 189.061 251.278 339.406 1.00 41.16  ? 46  LEU C N   1 
ATOM 3924 C CA  . LEU C 3 46  ? 188.680 250.880 340.752 1.00 40.68  ? 46  LEU C CA  1 
ATOM 3925 C C   . LEU C 3 46  ? 187.197 251.056 341.028 1.00 41.90  ? 46  LEU C C   1 
ATOM 3926 O O   . LEU C 3 46  ? 186.673 250.411 341.942 1.00 48.83  ? 46  LEU C O   1 
ATOM 3927 C CB  . LEU C 3 46  ? 189.457 251.686 341.794 1.00 42.01  ? 46  LEU C CB  1 
ATOM 3928 C CG  . LEU C 3 46  ? 190.975 251.558 341.791 1.00 40.60  ? 46  LEU C CG  1 
ATOM 3929 C CD1 . LEU C 3 46  ? 191.532 252.247 343.019 1.00 43.53  ? 46  LEU C CD1 1 
ATOM 3930 C CD2 . LEU C 3 46  ? 191.389 250.104 341.744 1.00 36.76  ? 46  LEU C CD2 1 
ATOM 3931 N N   . ALA C 3 47  ? 186.516 251.926 340.286 1.00 43.22  ? 47  ALA C N   1 
ATOM 3932 C CA  . ALA C 3 47  ? 185.086 252.104 340.480 1.00 42.93  ? 47  ALA C CA  1 
ATOM 3933 C C   . ALA C 3 47  ? 184.279 250.970 339.872 1.00 40.67  ? 47  ALA C C   1 
ATOM 3934 O O   . ALA C 3 47  ? 183.125 250.772 340.260 1.00 43.30  ? 47  ALA C O   1 
ATOM 3935 C CB  . ALA C 3 47  ? 184.636 253.435 339.883 1.00 43.74  ? 47  ALA C CB  1 
ATOM 3936 N N   . GLU C 3 48  ? 184.866 250.217 338.945 1.00 37.91  ? 48  GLU C N   1 
ATOM 3937 C CA  . GLU C 3 48  ? 184.210 249.090 338.304 1.00 40.04  ? 48  GLU C CA  1 
ATOM 3938 C C   . GLU C 3 48  ? 184.347 247.801 339.102 1.00 45.14  ? 48  GLU C C   1 
ATOM 3939 O O   . GLU C 3 48  ? 184.335 246.717 338.513 1.00 46.57  ? 48  GLU C O   1 
ATOM 3940 C CB  . GLU C 3 48  ? 184.775 248.887 336.900 1.00 41.42  ? 48  GLU C CB  1 
ATOM 3941 C CG  . GLU C 3 48  ? 184.747 250.128 336.039 1.00 42.13  ? 48  GLU C CG  1 
ATOM 3942 C CD  . GLU C 3 48  ? 185.418 249.913 334.703 1.00 48.92  ? 48  GLU C CD  1 
ATOM 3943 O OE1 . GLU C 3 48  ? 185.805 248.764 334.413 1.00 46.66  ? 48  GLU C OE1 1 
ATOM 3944 O OE2 . GLU C 3 48  ? 185.565 250.892 333.943 1.00 55.78  ? 48  GLU C OE2 1 
ATOM 3945 N N   . ILE C 3 49  ? 184.493 247.893 340.418 1.00 45.04  ? 49  ILE C N   1 
ATOM 3946 C CA  . ILE C 3 49  ? 184.613 246.731 341.288 1.00 43.40  ? 49  ILE C CA  1 
ATOM 3947 C C   . ILE C 3 49  ? 183.390 246.698 342.191 1.00 43.09  ? 49  ILE C C   1 
ATOM 3948 O O   . ILE C 3 49  ? 183.134 247.651 342.936 1.00 47.13  ? 49  ILE C O   1 
ATOM 3949 C CB  . ILE C 3 49  ? 185.911 246.776 342.106 1.00 41.45  ? 49  ILE C CB  1 
ATOM 3950 C CG1 . ILE C 3 49  ? 187.097 246.436 341.206 1.00 38.79  ? 49  ILE C CG1 1 
ATOM 3951 C CG2 . ILE C 3 49  ? 185.831 245.824 343.284 1.00 44.15  ? 49  ILE C CG2 1 
ATOM 3952 C CD1 . ILE C 3 49  ? 188.437 246.764 341.803 1.00 46.58  ? 49  ILE C CD1 1 
ATOM 3953 N N   . ASP C 3 50  ? 182.642 245.600 342.133 1.00 34.79  ? 50  ASP C N   1 
ATOM 3954 C CA  . ASP C 3 50  ? 181.435 245.471 342.935 1.00 35.28  ? 50  ASP C CA  1 
ATOM 3955 C C   . ASP C 3 50  ? 181.788 245.420 344.413 1.00 34.84  ? 50  ASP C C   1 
ATOM 3956 O O   . ASP C 3 50  ? 182.702 244.699 344.816 1.00 48.97  ? 50  ASP C O   1 
ATOM 3957 C CB  . ASP C 3 50  ? 180.673 244.214 342.534 1.00 46.66  ? 50  ASP C CB  1 
ATOM 3958 C CG  . ASP C 3 50  ? 180.457 244.117 341.043 1.00 54.67  ? 50  ASP C CG  1 
ATOM 3959 O OD1 . ASP C 3 50  ? 181.460 244.076 340.304 1.00 50.87  ? 50  ASP C OD1 1 
ATOM 3960 O OD2 . ASP C 3 50  ? 179.287 244.082 340.610 1.00 58.49  ? 50  ASP C OD2 1 
ATOM 3961 N N   . THR C 3 51  ? 181.069 246.188 345.222 1.00 32.16  ? 51  THR C N   1 
ATOM 3962 C CA  . THR C 3 51  ? 181.270 246.201 346.660 1.00 37.57  ? 51  THR C CA  1 
ATOM 3963 C C   . THR C 3 51  ? 179.921 246.228 347.359 1.00 35.35  ? 51  THR C C   1 
ATOM 3964 O O   . THR C 3 51  ? 178.961 246.816 346.864 1.00 39.30  ? 51  THR C O   1 
ATOM 3965 C CB  . THR C 3 51  ? 182.113 247.398 347.097 1.00 41.50  ? 51  THR C CB  1 
ATOM 3966 O OG1 . THR C 3 51  ? 181.508 248.607 346.629 1.00 51.01  ? 51  THR C OG1 1 
ATOM 3967 C CG2 . THR C 3 51  ? 183.516 247.291 346.531 1.00 39.33  ? 51  THR C CG2 1 
ATOM 3968 N N   . MET C 3 52  ? 179.862 245.589 348.520 1.00 37.87  ? 52  MET C N   1 
ATOM 3969 C CA  . MET C 3 52  ? 178.595 245.418 349.214 1.00 39.26  ? 52  MET C CA  1 
ATOM 3970 C C   . MET C 3 52  ? 178.044 246.754 349.692 1.00 38.00  ? 52  MET C C   1 
ATOM 3971 O O   . MET C 3 52  ? 178.786 247.627 350.145 1.00 42.82  ? 52  MET C O   1 
ATOM 3972 C CB  . MET C 3 52  ? 178.771 244.465 350.394 1.00 43.00  ? 52  MET C CB  1 
ATOM 3973 C CG  . MET C 3 52  ? 179.036 243.034 349.970 1.00 47.43  ? 52  MET C CG  1 
ATOM 3974 S SD  . MET C 3 52  ? 179.633 241.977 351.297 1.00 63.02  ? 52  MET C SD  1 
ATOM 3975 C CE  . MET C 3 52  ? 178.196 241.909 352.346 1.00 45.73  ? 52  MET C CE  1 
ATOM 3976 N N   . ILE C 3 53  ? 176.729 246.901 349.589 1.00 44.93  ? 53  ILE C N   1 
ATOM 3977 C CA  . ILE C 3 53  ? 176.035 248.122 349.984 1.00 37.88  ? 53  ILE C CA  1 
ATOM 3978 C C   . ILE C 3 53  ? 175.590 247.958 351.434 1.00 39.78  ? 53  ILE C C   1 
ATOM 3979 O O   . ILE C 3 53  ? 174.836 247.021 351.729 1.00 48.79  ? 53  ILE C O   1 
ATOM 3980 C CB  . ILE C 3 53  ? 174.827 248.389 349.080 1.00 32.97  ? 53  ILE C CB  1 
ATOM 3981 C CG1 . ILE C 3 53  ? 175.243 248.405 347.611 1.00 36.82  ? 53  ILE C CG1 1 
ATOM 3982 C CG2 . ILE C 3 53  ? 174.159 249.693 349.457 1.00 37.76  ? 53  ILE C CG2 1 
ATOM 3983 C CD1 . ILE C 3 53  ? 174.080 248.399 346.657 1.00 35.22  ? 53  ILE C CD1 1 
ATOM 3984 N N   . PRO C 3 54  ? 176.014 248.819 352.351 1.00 44.66  ? 54  PRO C N   1 
ATOM 3985 C CA  . PRO C 3 54  ? 175.482 248.734 353.715 1.00 47.43  ? 54  PRO C CA  1 
ATOM 3986 C C   . PRO C 3 54  ? 174.040 249.202 353.783 1.00 47.81  ? 54  PRO C C   1 
ATOM 3987 O O   . PRO C 3 54  ? 173.770 250.400 353.679 1.00 56.75  ? 54  PRO C O   1 
ATOM 3988 C CB  . PRO C 3 54  ? 176.413 249.651 354.511 1.00 45.03  ? 54  PRO C CB  1 
ATOM 3989 C CG  . PRO C 3 54  ? 176.911 250.615 353.523 1.00 45.52  ? 54  PRO C CG  1 
ATOM 3990 C CD  . PRO C 3 54  ? 177.039 249.868 352.235 1.00 47.76  ? 54  PRO C CD  1 
ATOM 3991 N N   . PHE C 3 55  ? 173.106 248.271 353.961 1.00 48.19  ? 55  PHE C N   1 
ATOM 3992 C CA  . PHE C 3 55  ? 171.689 248.600 353.907 1.00 49.23  ? 55  PHE C CA  1 
ATOM 3993 C C   . PHE C 3 55  ? 171.123 249.081 355.233 1.00 55.11  ? 55  PHE C C   1 
ATOM 3994 O O   . PHE C 3 55  ? 170.058 249.707 355.239 1.00 56.89  ? 55  PHE C O   1 
ATOM 3995 C CB  . PHE C 3 55  ? 170.880 247.385 353.440 1.00 44.87  ? 55  PHE C CB  1 
ATOM 3996 C CG  . PHE C 3 55  ? 170.918 247.164 351.961 1.00 46.81  ? 55  PHE C CG  1 
ATOM 3997 C CD1 . PHE C 3 55  ? 170.605 248.185 351.088 1.00 52.34  ? 55  PHE C CD1 1 
ATOM 3998 C CD2 . PHE C 3 55  ? 171.274 245.937 351.442 1.00 47.33  ? 55  PHE C CD2 1 
ATOM 3999 C CE1 . PHE C 3 55  ? 170.639 247.985 349.730 1.00 53.59  ? 55  PHE C CE1 1 
ATOM 4000 C CE2 . PHE C 3 55  ? 171.310 245.732 350.083 1.00 49.62  ? 55  PHE C CE2 1 
ATOM 4001 C CZ  . PHE C 3 55  ? 170.992 246.758 349.225 1.00 51.78  ? 55  PHE C CZ  1 
ATOM 4002 N N   . ASP C 3 56  ? 171.790 248.809 356.351 1.00 66.61  ? 56  ASP C N   1 
ATOM 4003 C CA  . ASP C 3 56  ? 171.277 249.166 357.674 1.00 67.70  ? 56  ASP C CA  1 
ATOM 4004 C C   . ASP C 3 56  ? 172.367 249.912 358.434 1.00 71.67  ? 56  ASP C C   1 
ATOM 4005 O O   . ASP C 3 56  ? 173.125 249.312 359.197 1.00 73.71  ? 56  ASP C O   1 
ATOM 4006 C CB  . ASP C 3 56  ? 170.816 247.930 358.432 1.00 66.31  ? 56  ASP C CB  1 
ATOM 4007 C CG  . ASP C 3 56  ? 169.829 247.102 357.645 1.00 70.17  ? 56  ASP C CG  1 
ATOM 4008 O OD1 . ASP C 3 56  ? 169.179 247.661 356.739 1.00 71.90  ? 56  ASP C OD1 1 
ATOM 4009 O OD2 . ASP C 3 56  ? 169.701 245.895 357.932 1.00 70.95  ? 56  ASP C OD2 1 
ATOM 4010 N N   . LEU C 3 57  ? 172.431 251.223 358.233 1.00 75.26  ? 57  LEU C N   1 
ATOM 4011 C CA  . LEU C 3 57  ? 173.302 252.088 359.010 1.00 74.32  ? 57  LEU C CA  1 
ATOM 4012 C C   . LEU C 3 57  ? 172.641 252.563 360.296 1.00 77.03  ? 57  LEU C C   1 
ATOM 4013 O O   . LEU C 3 57  ? 173.116 253.526 360.906 1.00 76.39  ? 57  LEU C O   1 
ATOM 4014 C CB  . LEU C 3 57  ? 173.738 253.291 358.173 1.00 68.95  ? 57  LEU C CB  1 
ATOM 4015 C CG  . LEU C 3 57  ? 174.788 252.991 357.103 1.00 70.65  ? 57  LEU C CG  1 
ATOM 4016 C CD1 . LEU C 3 57  ? 174.236 252.056 356.048 1.00 71.55  ? 57  LEU C CD1 1 
ATOM 4017 C CD2 . LEU C 3 57  ? 175.284 254.277 356.471 1.00 72.27  ? 57  LEU C CD2 1 
ATOM 4018 N N   . SER C 3 58  ? 171.556 251.916 360.715 1.00 84.23  ? 58  SER C N   1 
ATOM 4019 C CA  . SER C 3 58  ? 170.923 252.263 361.977 1.00 84.22  ? 58  SER C CA  1 
ATOM 4020 C C   . SER C 3 58  ? 171.895 252.040 363.126 1.00 84.85  ? 58  SER C C   1 
ATOM 4021 O O   . SER C 3 58  ? 172.688 251.096 363.115 1.00 84.08  ? 58  SER C O   1 
ATOM 4022 C CB  . SER C 3 58  ? 169.663 251.426 362.182 1.00 83.40  ? 58  SER C CB  1 
ATOM 4023 O OG  . SER C 3 58  ? 169.960 250.042 362.124 1.00 82.44  ? 58  SER C OG  1 
ATOM 4024 N N   . ALA C 3 59  ? 171.814 252.911 364.136 1.00 87.51  ? 59  ALA C N   1 
ATOM 4025 C CA  . ALA C 3 59  ? 172.772 252.863 365.235 1.00 86.28  ? 59  ALA C CA  1 
ATOM 4026 C C   . ALA C 3 59  ? 172.855 251.475 365.847 1.00 89.40  ? 59  ALA C C   1 
ATOM 4027 O O   . ALA C 3 59  ? 173.936 251.043 366.265 1.00 87.85  ? 59  ALA C O   1 
ATOM 4028 C CB  . ALA C 3 59  ? 172.387 253.885 366.305 1.00 85.32  ? 59  ALA C CB  1 
ATOM 4029 N N   . THR C 3 60  ? 171.733 250.763 365.908 1.00 90.23  ? 60  THR C N   1 
ATOM 4030 C CA  . THR C 3 60  ? 171.721 249.403 366.427 1.00 90.07  ? 60  THR C CA  1 
ATOM 4031 C C   . THR C 3 60  ? 172.675 248.514 365.637 1.00 88.48  ? 60  THR C C   1 
ATOM 4032 O O   . THR C 3 60  ? 173.618 247.950 366.201 1.00 87.81  ? 60  THR C O   1 
ATOM 4033 C CB  . THR C 3 60  ? 170.303 248.833 366.383 1.00 88.78  ? 60  THR C CB  1 
ATOM 4034 O OG1 . THR C 3 60  ? 169.789 248.931 365.049 1.00 86.92  ? 60  THR C OG1 1 
ATOM 4035 C CG2 . THR C 3 60  ? 169.394 249.599 367.331 1.00 87.93  ? 60  THR C CG2 1 
ATOM 4036 N N   . LYS C 3 61  ? 172.431 248.377 364.338 1.00 82.37  ? 61  LYS C N   1 
ATOM 4037 C CA  . LYS C 3 61  ? 173.262 247.542 363.470 1.00 80.78  ? 61  LYS C CA  1 
ATOM 4038 C C   . LYS C 3 61  ? 174.192 248.409 362.624 1.00 83.60  ? 61  LYS C C   1 
ATOM 4039 O O   . LYS C 3 61  ? 174.158 248.385 361.397 1.00 81.48  ? 61  LYS C O   1 
ATOM 4040 C CB  . LYS C 3 61  ? 172.381 246.668 362.583 1.00 79.40  ? 61  LYS C CB  1 
ATOM 4041 C CG  . LYS C 3 61  ? 171.182 246.069 363.285 1.00 82.08  ? 61  LYS C CG  1 
ATOM 4042 C CD  . LYS C 3 61  ? 170.391 245.185 362.338 1.00 80.65  ? 61  LYS C CD  1 
ATOM 4043 C CE  . LYS C 3 61  ? 169.036 244.820 362.914 1.00 81.12  ? 61  LYS C CE  1 
ATOM 4044 N NZ  . LYS C 3 61  ? 168.152 246.010 363.056 1.00 79.62  ? 61  LYS C NZ  1 
ATOM 4045 N N   . LYS C 3 62  ? 175.039 249.179 363.299 1.00 87.10  ? 62  LYS C N   1 
ATOM 4046 C CA  . LYS C 3 62  ? 175.963 250.091 362.641 1.00 83.42  ? 62  LYS C CA  1 
ATOM 4047 C C   . LYS C 3 62  ? 177.393 249.641 362.891 1.00 83.18  ? 62  LYS C C   1 
ATOM 4048 O O   . LYS C 3 62  ? 177.773 249.343 364.028 1.00 80.75  ? 62  LYS C O   1 
ATOM 4049 C CB  . LYS C 3 62  ? 175.776 251.526 363.141 1.00 81.91  ? 62  LYS C CB  1 
ATOM 4050 C CG  . LYS C 3 62  ? 176.626 252.549 362.409 1.00 82.73  ? 62  LYS C CG  1 
ATOM 4051 C CD  . LYS C 3 62  ? 176.479 253.937 363.013 1.00 84.60  ? 62  LYS C CD  1 
ATOM 4052 C CE  . LYS C 3 62  ? 175.128 254.559 362.695 1.00 83.83  ? 62  LYS C CE  1 
ATOM 4053 N NZ  . LYS C 3 62  ? 174.951 254.799 361.237 1.00 82.77  ? 62  LYS C NZ  1 
ATOM 4054 N N   . ASN C 3 63  ? 178.186 249.606 361.822 1.00 76.30  ? 63  ASN C N   1 
ATOM 4055 C CA  . ASN C 3 63  ? 179.580 249.182 361.897 1.00 72.86  ? 63  ASN C CA  1 
ATOM 4056 C C   . ASN C 3 63  ? 179.689 247.786 362.507 1.00 76.58  ? 63  ASN C C   1 
ATOM 4057 O O   . ASN C 3 63  ? 180.382 247.564 363.502 1.00 79.26  ? 63  ASN C O   1 
ATOM 4058 C CB  . ASN C 3 63  ? 180.415 250.197 362.676 1.00 73.19  ? 63  ASN C CB  1 
ATOM 4059 C CG  . ASN C 3 63  ? 180.700 251.448 361.872 1.00 78.26  ? 63  ASN C CG  1 
ATOM 4060 O OD1 . ASN C 3 63  ? 179.839 252.313 361.726 1.00 77.70  ? 63  ASN C OD1 1 
ATOM 4061 N ND2 . ASN C 3 63  ? 181.914 251.549 361.346 1.00 74.88  ? 63  ASN C ND2 1 
ATOM 4062 N N   . THR C 3 64  ? 178.980 246.841 361.898 1.00 68.95  ? 64  THR C N   1 
ATOM 4063 C CA  . THR C 3 64  ? 179.035 245.437 362.275 1.00 66.21  ? 64  THR C CA  1 
ATOM 4064 C C   . THR C 3 64  ? 178.817 244.612 361.013 1.00 65.81  ? 64  THR C C   1 
ATOM 4065 O O   . THR C 3 64  ? 178.904 245.126 359.895 1.00 68.21  ? 64  THR C O   1 
ATOM 4066 C CB  . THR C 3 64  ? 177.997 245.117 363.356 1.00 65.45  ? 64  THR C CB  1 
ATOM 4067 O OG1 . THR C 3 64  ? 176.689 245.452 362.880 1.00 68.23  ? 64  THR C OG1 1 
ATOM 4068 C CG2 . THR C 3 64  ? 178.279 245.895 364.627 1.00 68.77  ? 64  THR C CG2 1 
ATOM 4069 N N   . MET C 3 65  ? 178.537 243.324 361.188 1.00 62.71  ? 65  MET C N   1 
ATOM 4070 C CA  . MET C 3 65  ? 178.259 242.454 360.055 1.00 62.82  ? 65  MET C CA  1 
ATOM 4071 C C   . MET C 3 65  ? 176.791 242.437 359.658 1.00 64.02  ? 65  MET C C   1 
ATOM 4072 O O   . MET C 3 65  ? 176.469 241.964 358.564 1.00 65.02  ? 65  MET C O   1 
ATOM 4073 C CB  . MET C 3 65  ? 178.704 241.026 360.371 1.00 63.88  ? 65  MET C CB  1 
ATOM 4074 C CG  . MET C 3 65  ? 180.205 240.858 360.472 1.00 67.73  ? 65  MET C CG  1 
ATOM 4075 S SD  . MET C 3 65  ? 181.056 241.215 358.927 1.00 71.47  ? 65  MET C SD  1 
ATOM 4076 C CE  . MET C 3 65  ? 180.343 239.977 357.853 1.00 64.03  ? 65  MET C CE  1 
ATOM 4077 N N   . GLU C 3 66  ? 175.898 242.943 360.506 1.00 65.63  ? 66  GLU C N   1 
ATOM 4078 C CA  . GLU C 3 66  ? 174.472 242.884 360.220 1.00 64.33  ? 66  GLU C CA  1 
ATOM 4079 C C   . GLU C 3 66  ? 174.013 243.963 359.253 1.00 68.72  ? 66  GLU C C   1 
ATOM 4080 O O   . GLU C 3 66  ? 172.893 243.869 358.742 1.00 72.67  ? 66  GLU C O   1 
ATOM 4081 C CB  . GLU C 3 66  ? 173.658 243.008 361.510 1.00 65.94  ? 66  GLU C CB  1 
ATOM 4082 C CG  . GLU C 3 66  ? 173.924 241.928 362.537 1.00 69.37  ? 66  GLU C CG  1 
ATOM 4083 C CD  . GLU C 3 66  ? 175.185 242.182 363.331 1.00 75.32  ? 66  GLU C CD  1 
ATOM 4084 O OE1 . GLU C 3 66  ? 175.944 243.097 362.951 1.00 77.88  ? 66  GLU C OE1 1 
ATOM 4085 O OE2 . GLU C 3 66  ? 175.416 241.475 364.334 1.00 73.39  ? 66  GLU C OE2 1 
ATOM 4086 N N   . MET C 3 67  ? 174.833 244.973 358.985 1.00 59.78  ? 67  MET C N   1 
ATOM 4087 C CA  . MET C 3 67  ? 174.385 246.103 358.186 1.00 56.95  ? 67  MET C CA  1 
ATOM 4088 C C   . MET C 3 67  ? 174.457 245.845 356.689 1.00 55.73  ? 67  MET C C   1 
ATOM 4089 O O   . MET C 3 67  ? 174.021 246.699 355.913 1.00 61.66  ? 67  MET C O   1 
ATOM 4090 C CB  . MET C 3 67  ? 175.200 247.348 358.534 1.00 60.95  ? 67  MET C CB  1 
ATOM 4091 C CG  . MET C 3 67  ? 176.676 247.258 358.224 1.00 61.84  ? 67  MET C CG  1 
ATOM 4092 S SD  . MET C 3 67  ? 177.515 248.807 358.596 1.00 70.82  ? 67  MET C SD  1 
ATOM 4093 C CE  . MET C 3 67  ? 179.200 248.392 358.172 1.00 61.39  ? 67  MET C CE  1 
ATOM 4094 N N   . TYR C 3 68  ? 174.991 244.706 356.262 1.00 45.00  ? 68  TYR C N   1 
ATOM 4095 C CA  . TYR C 3 68  ? 175.067 244.369 354.849 1.00 40.47  ? 68  TYR C CA  1 
ATOM 4096 C C   . TYR C 3 68  ? 173.984 243.397 354.409 1.00 50.66  ? 68  TYR C C   1 
ATOM 4097 O O   . TYR C 3 68  ? 173.923 243.060 353.224 1.00 53.71  ? 68  TYR C O   1 
ATOM 4098 C CB  . TYR C 3 68  ? 176.433 243.769 354.526 1.00 41.24  ? 68  TYR C CB  1 
ATOM 4099 C CG  . TYR C 3 68  ? 177.593 244.705 354.743 1.00 51.48  ? 68  TYR C CG  1 
ATOM 4100 C CD1 . TYR C 3 68  ? 178.158 244.864 355.997 1.00 51.74  ? 68  TYR C CD1 1 
ATOM 4101 C CD2 . TYR C 3 68  ? 178.134 245.418 353.689 1.00 51.28  ? 68  TYR C CD2 1 
ATOM 4102 C CE1 . TYR C 3 68  ? 179.218 245.711 356.195 1.00 46.78  ? 68  TYR C CE1 1 
ATOM 4103 C CE2 . TYR C 3 68  ? 179.195 246.267 353.878 1.00 49.85  ? 68  TYR C CE2 1 
ATOM 4104 C CZ  . TYR C 3 68  ? 179.732 246.411 355.131 1.00 47.24  ? 68  TYR C CZ  1 
ATOM 4105 O OH  . TYR C 3 68  ? 180.792 247.261 355.318 1.00 51.28  ? 68  TYR C OH  1 
ATOM 4106 N N   . ARG C 3 69  ? 173.129 242.948 355.320 1.00 48.19  ? 69  ARG C N   1 
ATOM 4107 C CA  . ARG C 3 69  ? 172.143 241.919 355.033 1.00 45.61  ? 69  ARG C CA  1 
ATOM 4108 C C   . ARG C 3 69  ? 170.745 242.511 355.072 1.00 51.65  ? 69  ARG C C   1 
ATOM 4109 O O   . ARG C 3 69  ? 170.444 243.361 355.915 1.00 50.22  ? 69  ARG C O   1 
ATOM 4110 C CB  . ARG C 3 69  ? 172.225 240.777 356.045 1.00 46.17  ? 69  ARG C CB  1 
ATOM 4111 C CG  . ARG C 3 69  ? 173.564 240.093 356.111 1.00 48.45  ? 69  ARG C CG  1 
ATOM 4112 C CD  . ARG C 3 69  ? 173.764 239.466 357.467 1.00 49.27  ? 69  ARG C CD  1 
ATOM 4113 N NE  . ARG C 3 69  ? 175.095 238.895 357.609 1.00 49.52  ? 69  ARG C NE  1 
ATOM 4114 C CZ  . ARG C 3 69  ? 175.627 238.531 358.766 1.00 55.59  ? 69  ARG C CZ  1 
ATOM 4115 N NH1 . ARG C 3 69  ? 174.970 238.676 359.905 1.00 56.13  ? 69  ARG C NH1 1 
ATOM 4116 N NH2 . ARG C 3 69  ? 176.849 238.008 358.781 1.00 54.37  ? 69  ARG C NH2 1 
ATOM 4117 N N   . VAL C 3 70  ? 169.892 242.050 354.163 1.00 53.99  ? 70  VAL C N   1 
ATOM 4118 C CA  . VAL C 3 70  ? 168.472 242.369 354.186 1.00 45.75  ? 70  VAL C CA  1 
ATOM 4119 C C   . VAL C 3 70  ? 167.729 241.080 354.485 1.00 48.50  ? 70  VAL C C   1 
ATOM 4120 O O   . VAL C 3 70  ? 167.879 240.091 353.758 1.00 52.68  ? 70  VAL C O   1 
ATOM 4121 C CB  . VAL C 3 70  ? 167.998 242.984 352.863 1.00 42.91  ? 70  VAL C CB  1 
ATOM 4122 C CG1 . VAL C 3 70  ? 166.529 243.331 352.944 1.00 49.97  ? 70  VAL C CG1 1 
ATOM 4123 C CG2 . VAL C 3 70  ? 168.818 244.205 352.530 1.00 49.30  ? 70  VAL C CG2 1 
ATOM 4124 N N   . ARG C 3 71  ? 166.933 241.090 355.548 1.00 52.56  ? 71  ARG C N   1 
ATOM 4125 C CA  . ARG C 3 71  ? 166.276 239.887 356.035 1.00 52.14  ? 71  ARG C CA  1 
ATOM 4126 C C   . ARG C 3 71  ? 164.887 239.753 355.429 1.00 57.01  ? 71  ARG C C   1 
ATOM 4127 O O   . ARG C 3 71  ? 164.104 240.706 355.436 1.00 59.53  ? 71  ARG C O   1 
ATOM 4128 C CB  . ARG C 3 71  ? 166.179 239.916 357.558 1.00 51.52  ? 71  ARG C CB  1 
ATOM 4129 C CG  . ARG C 3 71  ? 165.270 238.845 358.130 1.00 56.57  ? 71  ARG C CG  1 
ATOM 4130 C CD  . ARG C 3 71  ? 165.824 238.272 359.418 1.00 59.61  ? 71  ARG C CD  1 
ATOM 4131 N NE  . ARG C 3 71  ? 167.099 237.602 359.198 1.00 63.15  ? 71  ARG C NE  1 
ATOM 4132 C CZ  . ARG C 3 71  ? 167.719 236.854 360.099 1.00 64.24  ? 71  ARG C CZ  1 
ATOM 4133 N NH1 . ARG C 3 71  ? 167.198 236.638 361.295 1.00 60.69  ? 71  ARG C NH1 1 
ATOM 4134 N NH2 . ARG C 3 71  ? 168.892 236.309 359.792 1.00 58.64  ? 71  ARG C NH2 1 
ATOM 4135 N N   . LEU C 3 72  ? 164.587 238.565 354.913 1.00 55.03  ? 72  LEU C N   1 
ATOM 4136 C CA  . LEU C 3 72  ? 163.258 238.214 354.427 1.00 48.12  ? 72  LEU C CA  1 
ATOM 4137 C C   . LEU C 3 72  ? 162.659 237.219 355.409 1.00 50.63  ? 72  LEU C C   1 
ATOM 4138 O O   . LEU C 3 72  ? 163.089 236.063 355.467 1.00 56.59  ? 72  LEU C O   1 
ATOM 4139 C CB  . LEU C 3 72  ? 163.324 237.620 353.025 1.00 45.32  ? 72  LEU C CB  1 
ATOM 4140 C CG  . LEU C 3 72  ? 164.160 238.404 352.021 1.00 44.53  ? 72  LEU C CG  1 
ATOM 4141 C CD1 . LEU C 3 72  ? 164.024 237.791 350.644 1.00 47.93  ? 72  LEU C CD1 1 
ATOM 4142 C CD2 . LEU C 3 72  ? 163.752 239.857 352.009 1.00 50.30  ? 72  LEU C CD2 1 
ATOM 4143 N N   . SER C 3 73  ? 161.671 237.666 356.173 1.00 59.89  ? 73  SER C N   1 
ATOM 4144 C CA  . SER C 3 73  ? 161.058 236.861 357.213 1.00 63.45  ? 73  SER C CA  1 
ATOM 4145 C C   . SER C 3 73  ? 159.749 236.262 356.705 1.00 63.12  ? 73  SER C C   1 
ATOM 4146 O O   . SER C 3 73  ? 159.377 236.418 355.539 1.00 62.83  ? 73  SER C O   1 
ATOM 4147 C CB  . SER C 3 73  ? 160.846 237.710 358.465 1.00 66.79  ? 73  SER C CB  1 
ATOM 4148 O OG  . SER C 3 73  ? 162.083 238.185 358.965 1.00 63.78  ? 73  SER C OG  1 
ATOM 4149 N N   . ASP C 3 74  ? 159.044 235.555 357.587 1.00 74.28  ? 74  ASP C N   1 
ATOM 4150 C CA  . ASP C 3 74  ? 157.791 234.900 357.241 1.00 79.57  ? 74  ASP C CA  1 
ATOM 4151 C C   . ASP C 3 74  ? 156.560 235.727 357.591 1.00 76.97  ? 74  ASP C C   1 
ATOM 4152 O O   . ASP C 3 74  ? 155.448 235.336 357.223 1.00 69.96  ? 74  ASP C O   1 
ATOM 4153 C CB  . ASP C 3 74  ? 157.699 233.543 357.948 1.00 76.47  ? 74  ASP C CB  1 
ATOM 4154 C CG  . ASP C 3 74  ? 156.567 232.687 357.421 1.00 76.95  ? 74  ASP C CG  1 
ATOM 4155 O OD1 . ASP C 3 74  ? 156.072 232.970 356.310 1.00 78.19  ? 74  ASP C OD1 1 
ATOM 4156 O OD2 . ASP C 3 74  ? 156.166 231.734 358.123 1.00 73.56  ? 74  ASP C OD2 1 
ATOM 4157 N N   . LYS C 3 75  ? 156.726 236.853 358.277 1.00 78.93  ? 75  LYS C N   1 
ATOM 4158 C CA  . LYS C 3 75  ? 155.578 237.637 358.692 1.00 81.26  ? 75  LYS C CA  1 
ATOM 4159 C C   . LYS C 3 75  ? 154.870 238.234 357.477 1.00 84.27  ? 75  LYS C C   1 
ATOM 4160 O O   . LYS C 3 75  ? 155.495 238.477 356.441 1.00 79.97  ? 75  LYS C O   1 
ATOM 4161 C CB  . LYS C 3 75  ? 156.007 238.753 359.638 1.00 79.32  ? 75  LYS C CB  1 
ATOM 4162 C CG  . LYS C 3 75  ? 156.365 238.269 361.031 1.00 80.37  ? 75  LYS C CG  1 
ATOM 4163 C CD  . LYS C 3 75  ? 157.169 239.304 361.804 1.00 81.51  ? 75  LYS C CD  1 
ATOM 4164 C CE  . LYS C 3 75  ? 158.589 239.438 361.269 1.00 78.76  ? 75  LYS C CE  1 
ATOM 4165 N NZ  . LYS C 3 75  ? 159.315 238.139 361.271 1.00 80.99  ? 75  LYS C NZ  1 
ATOM 4166 N N   . PRO C 3 76  ? 153.561 238.473 357.575 1.00 83.85  ? 76  PRO C N   1 
ATOM 4167 C CA  . PRO C 3 76  ? 152.846 239.077 356.448 1.00 78.15  ? 76  PRO C CA  1 
ATOM 4168 C C   . PRO C 3 76  ? 153.392 240.458 356.122 1.00 78.22  ? 76  PRO C C   1 
ATOM 4169 O O   . PRO C 3 76  ? 153.833 241.202 357.000 1.00 75.40  ? 76  PRO C O   1 
ATOM 4170 C CB  . PRO C 3 76  ? 151.395 239.150 356.940 1.00 77.72  ? 76  PRO C CB  1 
ATOM 4171 C CG  . PRO C 3 76  ? 151.310 238.166 358.055 1.00 76.29  ? 76  PRO C CG  1 
ATOM 4172 C CD  . PRO C 3 76  ? 152.657 238.170 358.698 1.00 79.79  ? 76  PRO C CD  1 
ATOM 4173 N N   . HIS C 3 77  ? 153.353 240.791 354.839 1.00 80.59  ? 77  HIS C N   1 
ATOM 4174 C CA  . HIS C 3 77  ? 153.814 242.079 354.344 1.00 76.74  ? 77  HIS C CA  1 
ATOM 4175 C C   . HIS C 3 77  ? 152.625 242.998 354.089 1.00 74.53  ? 77  HIS C C   1 
ATOM 4176 O O   . HIS C 3 77  ? 151.471 242.569 354.032 1.00 72.65  ? 77  HIS C O   1 
ATOM 4177 C CB  . HIS C 3 77  ? 154.646 241.907 353.068 1.00 74.21  ? 77  HIS C CB  1 
ATOM 4178 C CG  . HIS C 3 77  ? 154.203 240.768 352.202 1.00 78.35  ? 77  HIS C CG  1 
ATOM 4179 N ND1 . HIS C 3 77  ? 154.642 239.476 352.393 1.00 78.11  ? 77  HIS C ND1 1 
ATOM 4180 C CD2 . HIS C 3 77  ? 153.360 240.725 351.144 1.00 74.25  ? 77  HIS C CD2 1 
ATOM 4181 C CE1 . HIS C 3 77  ? 154.092 238.687 351.489 1.00 73.48  ? 77  HIS C CE1 1 
ATOM 4182 N NE2 . HIS C 3 77  ? 153.310 239.420 350.718 1.00 73.42  ? 77  HIS C NE2 1 
ATOM 4183 N N   . THR C 3 78  ? 152.926 244.285 353.936 1.00 79.47  ? 78  THR C N   1 
ATOM 4184 C CA  . THR C 3 78  ? 151.911 245.317 353.767 1.00 82.92  ? 78  THR C CA  1 
ATOM 4185 C C   . THR C 3 78  ? 152.000 245.964 352.390 1.00 81.64  ? 78  THR C C   1 
ATOM 4186 O O   . THR C 3 78  ? 151.644 247.130 352.219 1.00 80.64  ? 78  THR C O   1 
ATOM 4187 C CB  . THR C 3 78  ? 152.036 246.378 354.859 1.00 83.18  ? 78  THR C CB  1 
ATOM 4188 O OG1 . THR C 3 78  ? 153.301 247.041 354.743 1.00 82.35  ? 78  THR C OG1 1 
ATOM 4189 C CG2 . THR C 3 78  ? 151.922 245.744 356.240 1.00 79.11  ? 78  THR C CG2 1 
ATOM 4190 N N   . ASP C 3 79  ? 152.477 245.216 351.398 1.00 76.73  ? 79  ASP C N   1 
ATOM 4191 C CA  . ASP C 3 79  ? 152.618 245.706 350.031 1.00 76.35  ? 79  ASP C CA  1 
ATOM 4192 C C   . ASP C 3 79  ? 153.614 246.857 349.934 1.00 75.17  ? 79  ASP C C   1 
ATOM 4193 O O   . ASP C 3 79  ? 153.628 247.588 348.940 1.00 76.41  ? 79  ASP C O   1 
ATOM 4194 C CB  . ASP C 3 79  ? 151.262 246.131 349.461 1.00 74.08  ? 79  ASP C CB  1 
ATOM 4195 C CG  . ASP C 3 79  ? 151.278 246.257 347.951 1.00 76.81  ? 79  ASP C CG  1 
ATOM 4196 O OD1 . ASP C 3 79  ? 152.345 246.030 347.341 1.00 76.46  ? 79  ASP C OD1 1 
ATOM 4197 O OD2 . ASP C 3 79  ? 150.221 246.583 347.371 1.00 74.64  ? 79  ASP C OD2 1 
ATOM 4198 N N   . ASP C 3 80  ? 154.457 247.036 350.956 1.00 65.80  ? 80  ASP C N   1 
ATOM 4199 C CA  . ASP C 3 80  ? 155.520 248.023 350.911 1.00 64.08  ? 80  ASP C CA  1 
ATOM 4200 C C   . ASP C 3 80  ? 156.831 247.365 350.499 1.00 64.34  ? 80  ASP C C   1 
ATOM 4201 O O   . ASP C 3 80  ? 157.025 246.166 350.715 1.00 64.01  ? 80  ASP C O   1 
ATOM 4202 C CB  . ASP C 3 80  ? 155.693 248.700 352.274 1.00 66.21  ? 80  ASP C CB  1 
ATOM 4203 C CG  . ASP C 3 80  ? 155.819 247.706 353.403 1.00 72.52  ? 80  ASP C CG  1 
ATOM 4204 O OD1 . ASP C 3 80  ? 155.122 246.671 353.357 1.00 75.83  ? 80  ASP C OD1 1 
ATOM 4205 O OD2 . ASP C 3 80  ? 156.612 247.955 354.334 1.00 72.61  ? 80  ASP C OD2 1 
ATOM 4206 N N   . PRO C 3 81  ? 157.751 248.119 349.899 1.00 52.75  ? 81  PRO C N   1 
ATOM 4207 C CA  . PRO C 3 81  ? 158.963 247.500 349.356 1.00 54.11  ? 81  PRO C CA  1 
ATOM 4208 C C   . PRO C 3 81  ? 159.842 246.896 350.440 1.00 56.16  ? 81  PRO C C   1 
ATOM 4209 O O   . PRO C 3 81  ? 159.884 247.369 351.577 1.00 52.66  ? 81  PRO C O   1 
ATOM 4210 C CB  . PRO C 3 81  ? 159.668 248.662 348.648 1.00 48.96  ? 81  PRO C CB  1 
ATOM 4211 C CG  . PRO C 3 81  ? 159.149 249.872 349.303 1.00 52.33  ? 81  PRO C CG  1 
ATOM 4212 C CD  . PRO C 3 81  ? 157.738 249.573 349.684 1.00 51.16  ? 81  PRO C CD  1 
ATOM 4213 N N   . ILE C 3 82  ? 160.544 245.825 350.068 1.00 51.80  ? 82  ILE C N   1 
ATOM 4214 C CA  . ILE C 3 82  ? 161.550 245.247 350.953 1.00 45.96  ? 82  ILE C CA  1 
ATOM 4215 C C   . ILE C 3 82  ? 162.657 246.256 351.210 1.00 49.59  ? 82  ILE C C   1 
ATOM 4216 O O   . ILE C 3 82  ? 163.080 246.468 352.351 1.00 55.46  ? 82  ILE C O   1 
ATOM 4217 C CB  . ILE C 3 82  ? 162.108 243.947 350.346 1.00 49.42  ? 82  ILE C CB  1 
ATOM 4218 C CG1 . ILE C 3 82  ? 161.012 242.885 350.268 1.00 50.86  ? 82  ILE C CG1 1 
ATOM 4219 C CG2 . ILE C 3 82  ? 163.296 243.448 351.153 1.00 47.94  ? 82  ILE C CG2 1 
ATOM 4220 C CD1 . ILE C 3 82  ? 161.414 241.649 349.504 1.00 50.73  ? 82  ILE C CD1 1 
ATOM 4221 N N   . LEU C 3 83  ? 163.141 246.893 350.147 1.00 51.84  ? 83  LEU C N   1 
ATOM 4222 C CA  . LEU C 3 83  ? 164.161 247.922 350.248 1.00 46.12  ? 83  LEU C CA  1 
ATOM 4223 C C   . LEU C 3 83  ? 163.990 248.885 349.087 1.00 46.16  ? 83  LEU C C   1 
ATOM 4224 O O   . LEU C 3 83  ? 163.697 248.467 347.962 1.00 52.37  ? 83  LEU C O   1 
ATOM 4225 C CB  . LEU C 3 83  ? 165.571 247.322 350.238 1.00 45.13  ? 83  LEU C CB  1 
ATOM 4226 C CG  . LEU C 3 83  ? 166.021 246.661 348.935 1.00 46.68  ? 83  LEU C CG  1 
ATOM 4227 C CD1 . LEU C 3 83  ? 166.791 247.628 348.055 1.00 47.01  ? 83  LEU C CD1 1 
ATOM 4228 C CD2 . LEU C 3 83  ? 166.853 245.433 349.230 1.00 50.38  ? 83  LEU C CD2 1 
ATOM 4229 N N   . CYS C 3 84  ? 164.160 250.173 349.377 1.00 53.13  ? 84  CYS C N   1 
ATOM 4230 C CA  . CYS C 3 84  ? 164.135 251.231 348.375 1.00 53.58  ? 84  CYS C CA  1 
ATOM 4231 C C   . CYS C 3 84  ? 165.408 252.046 348.517 1.00 52.45  ? 84  CYS C C   1 
ATOM 4232 O O   . CYS C 3 84  ? 165.698 252.561 349.601 1.00 53.75  ? 84  CYS C O   1 
ATOM 4233 C CB  . CYS C 3 84  ? 162.904 252.125 348.539 1.00 57.38  ? 84  CYS C CB  1 
ATOM 4234 S SG  . CYS C 3 84  ? 162.815 253.486 347.359 1.00 69.69  ? 84  CYS C SG  1 
ATOM 4235 N N   . LEU C 3 85  ? 166.156 252.172 347.427 1.00 46.98  ? 85  LEU C N   1 
ATOM 4236 C CA  . LEU C 3 85  ? 167.468 252.799 347.435 1.00 39.97  ? 85  LEU C CA  1 
ATOM 4237 C C   . LEU C 3 85  ? 167.496 253.933 346.423 1.00 49.38  ? 85  LEU C C   1 
ATOM 4238 O O   . LEU C 3 85  ? 167.141 253.736 345.255 1.00 53.63  ? 85  LEU C O   1 
ATOM 4239 C CB  . LEU C 3 85  ? 168.550 251.768 347.113 1.00 43.00  ? 85  LEU C CB  1 
ATOM 4240 C CG  . LEU C 3 85  ? 170.004 252.205 347.261 1.00 47.23  ? 85  LEU C CG  1 
ATOM 4241 C CD1 . LEU C 3 85  ? 170.343 252.471 348.714 1.00 48.56  ? 85  LEU C CD1 1 
ATOM 4242 C CD2 . LEU C 3 85  ? 170.917 251.149 346.680 1.00 51.42  ? 85  LEU C CD2 1 
ATOM 4243 N N   . SER C 3 86  ? 167.924 255.110 346.873 1.00 53.20  ? 86  SER C N   1 
ATOM 4244 C CA  . SER C 3 86  ? 168.070 256.266 346.003 1.00 46.57  ? 86  SER C CA  1 
ATOM 4245 C C   . SER C 3 86  ? 169.307 256.122 345.124 1.00 43.04  ? 86  SER C C   1 
ATOM 4246 O O   . SER C 3 86  ? 170.213 255.337 345.404 1.00 50.49  ? 86  SER C O   1 
ATOM 4247 C CB  . SER C 3 86  ? 168.174 257.544 346.829 1.00 46.62  ? 86  SER C CB  1 
ATOM 4248 O OG  . SER C 3 86  ? 167.118 257.627 347.766 1.00 55.06  ? 86  SER C OG  1 
ATOM 4249 N N   . LEU C 3 87  ? 169.346 256.907 344.055 1.00 42.40  ? 87  LEU C N   1 
ATOM 4250 C CA  . LEU C 3 87  ? 170.415 256.835 343.066 1.00 45.11  ? 87  LEU C CA  1 
ATOM 4251 C C   . LEU C 3 87  ? 171.317 258.064 343.117 1.00 46.68  ? 87  LEU C C   1 
ATOM 4252 O O   . LEU C 3 87  ? 171.746 258.585 342.087 1.00 50.06  ? 87  LEU C O   1 
ATOM 4253 C CB  . LEU C 3 87  ? 169.838 256.646 341.667 1.00 46.89  ? 87  LEU C CB  1 
ATOM 4254 C CG  . LEU C 3 87  ? 169.497 255.206 341.287 1.00 39.84  ? 87  LEU C CG  1 
ATOM 4255 C CD1 . LEU C 3 87  ? 168.735 255.167 339.979 1.00 48.82  ? 87  LEU C CD1 1 
ATOM 4256 C CD2 . LEU C 3 87  ? 170.755 254.377 341.190 1.00 48.23  ? 87  LEU C CD2 1 
ATOM 4257 N N   . SER C 3 88  ? 171.614 258.538 344.323 1.00 52.19  ? 88  SER C N   1 
ATOM 4258 C CA  . SER C 3 88  ? 172.637 259.556 344.517 1.00 50.23  ? 88  SER C CA  1 
ATOM 4259 C C   . SER C 3 88  ? 173.938 258.870 344.914 1.00 51.54  ? 88  SER C C   1 
ATOM 4260 O O   . SER C 3 88  ? 174.145 258.577 346.098 1.00 51.01  ? 88  SER C O   1 
ATOM 4261 C CB  . SER C 3 88  ? 172.215 260.557 345.588 1.00 48.92  ? 88  SER C CB  1 
ATOM 4262 O OG  . SER C 3 88  ? 170.980 261.163 345.258 1.00 58.24  ? 88  SER C OG  1 
ATOM 4263 N N   . PRO C 3 89  ? 174.836 258.593 343.968 1.00 47.32  ? 89  PRO C N   1 
ATOM 4264 C CA  . PRO C 3 89  ? 176.031 257.809 344.310 1.00 46.48  ? 89  PRO C CA  1 
ATOM 4265 C C   . PRO C 3 89  ? 176.939 258.479 345.323 1.00 48.41  ? 89  PRO C C   1 
ATOM 4266 O O   . PRO C 3 89  ? 177.788 257.800 345.909 1.00 51.96  ? 89  PRO C O   1 
ATOM 4267 C CB  . PRO C 3 89  ? 176.730 257.625 342.956 1.00 46.11  ? 89  PRO C CB  1 
ATOM 4268 C CG  . PRO C 3 89  ? 176.201 258.695 342.098 1.00 44.98  ? 89  PRO C CG  1 
ATOM 4269 C CD  . PRO C 3 89  ? 174.799 258.931 342.537 1.00 44.32  ? 89  PRO C CD  1 
ATOM 4270 N N   . ALA C 3 90  ? 176.805 259.787 345.541 1.00 51.37  ? 90  ALA C N   1 
ATOM 4271 C CA  . ALA C 3 90  ? 177.642 260.501 346.498 1.00 47.58  ? 90  ALA C CA  1 
ATOM 4272 C C   . ALA C 3 90  ? 176.815 261.377 347.431 1.00 48.23  ? 90  ALA C C   1 
ATOM 4273 O O   . ALA C 3 90  ? 177.359 262.291 348.055 1.00 48.39  ? 90  ALA C O   1 
ATOM 4274 C CB  . ALA C 3 90  ? 178.686 261.349 345.770 1.00 47.63  ? 90  ALA C CB  1 
ATOM 4275 N N   . SER C 3 91  ? 175.512 261.118 347.537 1.00 54.63  ? 91  SER C N   1 
ATOM 4276 C CA  . SER C 3 91  ? 174.652 261.899 348.415 1.00 59.70  ? 91  SER C CA  1 
ATOM 4277 C C   . SER C 3 91  ? 173.688 261.020 349.201 1.00 60.96  ? 91  SER C C   1 
ATOM 4278 O O   . SER C 3 91  ? 172.792 261.553 349.867 1.00 54.45  ? 91  SER C O   1 
ATOM 4279 C CB  . SER C 3 91  ? 173.869 262.935 347.606 1.00 59.75  ? 91  SER C CB  1 
ATOM 4280 O OG  . SER C 3 91  ? 174.585 263.310 346.444 1.00 62.46  ? 91  SER C OG  1 
ATOM 4281 N N   . ASP C 3 92  ? 173.837 259.699 349.135 1.00 62.55  ? 92  ASP C N   1 
ATOM 4282 C CA  . ASP C 3 92  ? 173.026 258.763 349.895 1.00 55.26  ? 92  ASP C CA  1 
ATOM 4283 C C   . ASP C 3 92  ? 173.901 258.121 350.959 1.00 57.77  ? 92  ASP C C   1 
ATOM 4284 O O   . ASP C 3 92  ? 174.933 257.530 350.611 1.00 61.13  ? 92  ASP C O   1 
ATOM 4285 C CB  . ASP C 3 92  ? 172.435 257.701 348.973 1.00 52.53  ? 92  ASP C CB  1 
ATOM 4286 C CG  . ASP C 3 92  ? 171.383 256.859 349.653 1.00 58.46  ? 92  ASP C CG  1 
ATOM 4287 O OD1 . ASP C 3 92  ? 171.136 257.077 350.855 1.00 59.88  ? 92  ASP C OD1 1 
ATOM 4288 O OD2 . ASP C 3 92  ? 170.800 255.979 348.987 1.00 58.40  ? 92  ASP C OD2 1 
ATOM 4289 N N   . PRO C 3 93  ? 173.568 258.209 352.249 1.00 53.37  ? 93  PRO C N   1 
ATOM 4290 C CA  . PRO C 3 93  ? 174.468 257.642 353.266 1.00 54.50  ? 93  PRO C CA  1 
ATOM 4291 C C   . PRO C 3 93  ? 174.725 256.159 353.090 1.00 54.56  ? 93  PRO C C   1 
ATOM 4292 O O   . PRO C 3 93  ? 175.785 255.677 353.503 1.00 53.38  ? 93  PRO C O   1 
ATOM 4293 C CB  . PRO C 3 93  ? 173.735 257.932 354.581 1.00 54.27  ? 93  PRO C CB  1 
ATOM 4294 C CG  . PRO C 3 93  ? 172.857 259.081 354.276 1.00 54.79  ? 93  PRO C CG  1 
ATOM 4295 C CD  . PRO C 3 93  ? 172.421 258.897 352.862 1.00 49.66  ? 93  PRO C CD  1 
ATOM 4296 N N   . ARG C 3 94  ? 173.797 255.422 352.492 1.00 55.12  ? 94  ARG C N   1 
ATOM 4297 C CA  . ARG C 3 94  ? 173.942 253.987 352.307 1.00 51.09  ? 94  ARG C CA  1 
ATOM 4298 C C   . ARG C 3 94  ? 174.700 253.629 351.041 1.00 51.55  ? 94  ARG C C   1 
ATOM 4299 O O   . ARG C 3 94  ? 174.857 252.442 350.750 1.00 63.53  ? 94  ARG C O   1 
ATOM 4300 C CB  . ARG C 3 94  ? 172.568 253.320 352.273 1.00 47.73  ? 94  ARG C CB  1 
ATOM 4301 C CG  . ARG C 3 94  ? 171.700 253.661 353.459 1.00 55.05  ? 94  ARG C CG  1 
ATOM 4302 C CD  . ARG C 3 94  ? 170.527 252.715 353.573 1.00 56.57  ? 94  ARG C CD  1 
ATOM 4303 N NE  . ARG C 3 94  ? 169.696 252.721 352.377 1.00 55.98  ? 94  ARG C NE  1 
ATOM 4304 C CZ  . ARG C 3 94  ? 168.541 252.078 352.268 1.00 54.95  ? 94  ARG C CZ  1 
ATOM 4305 N NH1 . ARG C 3 94  ? 168.045 251.375 353.272 1.00 52.95  ? 94  ARG C NH1 1 
ATOM 4306 N NH2 . ARG C 3 94  ? 167.866 252.146 351.126 1.00 57.13  ? 94  ARG C NH2 1 
ATOM 4307 N N   . LEU C 3 95  ? 175.162 254.614 350.279 1.00 45.80  ? 95  LEU C N   1 
ATOM 4308 C CA  . LEU C 3 95  ? 175.832 254.349 349.019 1.00 43.57  ? 95  LEU C CA  1 
ATOM 4309 C C   . LEU C 3 95  ? 177.098 255.168 348.838 1.00 43.59  ? 95  LEU C C   1 
ATOM 4310 O O   . LEU C 3 95  ? 177.776 255.008 347.819 1.00 41.31  ? 95  LEU C O   1 
ATOM 4311 C CB  . LEU C 3 95  ? 174.879 254.626 347.849 1.00 45.98  ? 95  LEU C CB  1 
ATOM 4312 C CG  . LEU C 3 95  ? 175.183 253.918 346.531 1.00 45.90  ? 95  LEU C CG  1 
ATOM 4313 C CD1 . LEU C 3 95  ? 174.960 252.430 346.672 1.00 47.27  ? 95  LEU C CD1 1 
ATOM 4314 C CD2 . LEU C 3 95  ? 174.325 254.483 345.415 1.00 52.28  ? 95  LEU C CD2 1 
ATOM 4315 N N   . SER C 3 96  ? 177.438 256.032 349.792 1.00 42.65  ? 96  SER C N   1 
ATOM 4316 C CA  . SER C 3 96  ? 178.602 256.893 349.669 1.00 44.45  ? 96  SER C CA  1 
ATOM 4317 C C   . SER C 3 96  ? 179.875 256.259 350.203 1.00 46.90  ? 96  SER C C   1 
ATOM 4318 O O   . SER C 3 96  ? 180.967 256.740 349.885 1.00 48.44  ? 96  SER C O   1 
ATOM 4319 C CB  . SER C 3 96  ? 178.355 258.209 350.406 1.00 53.19  ? 96  SER C CB  1 
ATOM 4320 O OG  . SER C 3 96  ? 178.202 257.990 351.796 1.00 51.91  ? 96  SER C OG  1 
ATOM 4321 N N   . HIS C 3 97  ? 179.767 255.202 351.001 1.00 48.79  ? 97  HIS C N   1 
ATOM 4322 C CA  . HIS C 3 97  ? 180.928 254.553 351.593 1.00 45.80  ? 97  HIS C CA  1 
ATOM 4323 C C   . HIS C 3 97  ? 181.441 253.382 350.773 1.00 42.73  ? 97  HIS C C   1 
ATOM 4324 O O   . HIS C 3 97  ? 182.388 252.719 351.199 1.00 51.58  ? 97  HIS C O   1 
ATOM 4325 C CB  . HIS C 3 97  ? 180.599 254.080 353.007 1.00 52.54  ? 97  HIS C CB  1 
ATOM 4326 C CG  . HIS C 3 97  ? 180.529 255.189 354.009 1.00 57.98  ? 97  HIS C CG  1 
ATOM 4327 N ND1 . HIS C 3 97  ? 181.569 256.068 354.217 1.00 51.69  ? 97  HIS C ND1 1 
ATOM 4328 C CD2 . HIS C 3 97  ? 179.545 255.561 354.860 1.00 54.28  ? 97  HIS C CD2 1 
ATOM 4329 C CE1 . HIS C 3 97  ? 181.229 256.936 355.151 1.00 53.88  ? 97  HIS C CE1 1 
ATOM 4330 N NE2 . HIS C 3 97  ? 180.006 256.650 355.559 1.00 57.18  ? 97  HIS C NE2 1 
ATOM 4331 N N   . THR C 3 98  ? 180.850 253.107 349.620 1.00 39.39  ? 98  THR C N   1 
ATOM 4332 C CA  . THR C 3 98  ? 181.369 252.076 348.742 1.00 36.88  ? 98  THR C CA  1 
ATOM 4333 C C   . THR C 3 98  ? 182.606 252.602 348.018 1.00 36.84  ? 98  THR C C   1 
ATOM 4334 O O   . THR C 3 98  ? 182.995 253.760 348.164 1.00 46.15  ? 98  THR C O   1 
ATOM 4335 C CB  . THR C 3 98  ? 180.293 251.634 347.758 1.00 38.89  ? 98  THR C CB  1 
ATOM 4336 O OG1 . THR C 3 98  ? 179.910 252.743 346.941 1.00 53.78  ? 98  THR C OG1 1 
ATOM 4337 C CG2 . THR C 3 98  ? 179.077 251.122 348.499 1.00 35.48  ? 98  THR C CG2 1 
ATOM 4338 N N   . MET C 3 99  ? 183.247 251.739 347.232 1.00 33.73  ? 99  MET C N   1 
ATOM 4339 C CA  . MET C 3 99  ? 184.401 252.187 346.461 1.00 38.67  ? 99  MET C CA  1 
ATOM 4340 C C   . MET C 3 99  ? 184.000 253.275 345.477 1.00 42.77  ? 99  MET C C   1 
ATOM 4341 O O   . MET C 3 99  ? 184.717 254.268 345.307 1.00 51.38  ? 99  MET C O   1 
ATOM 4342 C CB  . MET C 3 99  ? 185.032 251.005 345.726 1.00 46.23  ? 99  MET C CB  1 
ATOM 4343 C CG  . MET C 3 99  ? 186.438 251.263 345.203 1.00 44.99  ? 99  MET C CG  1 
ATOM 4344 S SD  . MET C 3 99  ? 187.602 251.776 346.485 1.00 64.06  ? 99  MET C SD  1 
ATOM 4345 C CE  . MET C 3 99  ? 187.271 250.565 347.757 1.00 46.79  ? 99  MET C CE  1 
ATOM 4346 N N   . LEU C 3 100 ? 182.848 253.107 344.826 1.00 44.88  ? 100 LEU C N   1 
ATOM 4347 C CA  . LEU C 3 100 ? 182.347 254.134 343.922 1.00 38.23  ? 100 LEU C CA  1 
ATOM 4348 C C   . LEU C 3 100 ? 182.139 255.451 344.655 1.00 33.95  ? 100 LEU C C   1 
ATOM 4349 O O   . LEU C 3 100 ? 182.522 256.514 344.158 1.00 44.41  ? 100 LEU C O   1 
ATOM 4350 C CB  . LEU C 3 100 ? 181.043 253.660 343.285 1.00 42.68  ? 100 LEU C CB  1 
ATOM 4351 C CG  . LEU C 3 100 ? 180.377 254.562 342.248 1.00 44.50  ? 100 LEU C CG  1 
ATOM 4352 C CD1 . LEU C 3 100 ? 181.263 254.743 341.034 1.00 46.85  ? 100 LEU C CD1 1 
ATOM 4353 C CD2 . LEU C 3 100 ? 179.039 253.982 341.846 1.00 39.89  ? 100 LEU C CD2 1 
ATOM 4354 N N   . GLY C 3 101 ? 181.542 255.399 345.843 1.00 29.13  ? 101 GLY C N   1 
ATOM 4355 C CA  . GLY C 3 101 ? 181.333 256.616 346.603 1.00 32.41  ? 101 GLY C CA  1 
ATOM 4356 C C   . GLY C 3 101 ? 182.632 257.305 346.966 1.00 39.22  ? 101 GLY C C   1 
ATOM 4357 O O   . GLY C 3 101 ? 182.737 258.531 346.895 1.00 51.73  ? 101 GLY C O   1 
ATOM 4358 N N   . GLU C 3 102 ? 183.643 256.530 347.355 1.00 48.90  ? 102 GLU C N   1 
ATOM 4359 C CA  . GLU C 3 102 ? 184.906 257.124 347.771 1.00 45.27  ? 102 GLU C CA  1 
ATOM 4360 C C   . GLU C 3 102 ? 185.730 257.629 346.599 1.00 41.57  ? 102 GLU C C   1 
ATOM 4361 O O   . GLU C 3 102 ? 186.574 258.506 346.791 1.00 48.97  ? 102 GLU C O   1 
ATOM 4362 C CB  . GLU C 3 102 ? 185.708 256.119 348.589 1.00 37.44  ? 102 GLU C CB  1 
ATOM 4363 C CG  . GLU C 3 102 ? 185.304 256.115 350.046 1.00 44.71  ? 102 GLU C CG  1 
ATOM 4364 C CD  . GLU C 3 102 ? 185.730 254.869 350.769 1.00 57.49  ? 102 GLU C CD  1 
ATOM 4365 O OE1 . GLU C 3 102 ? 186.061 253.877 350.090 1.00 65.53  ? 102 GLU C OE1 1 
ATOM 4366 O OE2 . GLU C 3 102 ? 185.729 254.880 352.018 1.00 57.91  ? 102 GLU C OE2 1 
ATOM 4367 N N   . ILE C 3 103 ? 185.514 257.103 345.396 1.00 34.59  ? 103 ILE C N   1 
ATOM 4368 C CA  . ILE C 3 103 ? 186.166 257.697 344.235 1.00 31.16  ? 103 ILE C CA  1 
ATOM 4369 C C   . ILE C 3 103 ? 185.416 258.938 343.774 1.00 37.39  ? 103 ILE C C   1 
ATOM 4370 O O   . ILE C 3 103 ? 186.023 259.869 343.241 1.00 40.42  ? 103 ILE C O   1 
ATOM 4371 C CB  . ILE C 3 103 ? 186.294 256.670 343.102 1.00 35.90  ? 103 ILE C CB  1 
ATOM 4372 C CG1 . ILE C 3 103 ? 187.198 255.521 343.544 1.00 41.05  ? 103 ILE C CG1 1 
ATOM 4373 C CG2 . ILE C 3 103 ? 186.847 257.335 341.856 1.00 38.11  ? 103 ILE C CG2 1 
ATOM 4374 C CD1 . ILE C 3 103 ? 187.173 254.331 342.621 1.00 46.75  ? 103 ILE C CD1 1 
ATOM 4375 N N   . LEU C 3 104 ? 184.096 258.975 343.964 1.00 44.21  ? 104 LEU C N   1 
ATOM 4376 C CA  . LEU C 3 104 ? 183.333 260.164 343.605 1.00 34.55  ? 104 LEU C CA  1 
ATOM 4377 C C   . LEU C 3 104 ? 183.554 261.299 344.592 1.00 33.00  ? 104 LEU C C   1 
ATOM 4378 O O   . LEU C 3 104 ? 183.396 262.467 344.233 1.00 47.56  ? 104 LEU C O   1 
ATOM 4379 C CB  . LEU C 3 104 ? 181.847 259.829 343.525 1.00 26.61  ? 104 LEU C CB  1 
ATOM 4380 C CG  . LEU C 3 104 ? 181.303 259.521 342.133 1.00 35.32  ? 104 LEU C CG  1 
ATOM 4381 C CD1 . LEU C 3 104 ? 182.146 258.480 341.427 1.00 40.67  ? 104 LEU C CD1 1 
ATOM 4382 C CD2 . LEU C 3 104 ? 179.874 259.064 342.251 1.00 40.02  ? 104 LEU C CD2 1 
ATOM 4383 N N   . ASN C 3 105 ? 183.903 260.982 345.835 1.00 32.38  ? 105 ASN C N   1 
ATOM 4384 C CA  . ASN C 3 105 ? 184.120 262.023 346.829 1.00 34.36  ? 105 ASN C CA  1 
ATOM 4385 C C   . ASN C 3 105 ? 185.365 262.855 346.553 1.00 33.04  ? 105 ASN C C   1 
ATOM 4386 O O   . ASN C 3 105 ? 185.574 263.865 347.229 1.00 30.50  ? 105 ASN C O   1 
ATOM 4387 C CB  . ASN C 3 105 ? 184.209 261.396 348.216 1.00 35.23  ? 105 ASN C CB  1 
ATOM 4388 C CG  . ASN C 3 105 ? 184.264 262.428 349.317 1.00 44.68  ? 105 ASN C CG  1 
ATOM 4389 O OD1 . ASN C 3 105 ? 185.317 262.674 349.902 1.00 42.86  ? 105 ASN C OD1 1 
ATOM 4390 N ND2 . ASN C 3 105 ? 183.127 263.045 349.604 1.00 49.29  ? 105 ASN C ND2 1 
ATOM 4391 N N   . TYR C 3 106 ? 186.196 262.459 345.594 1.00 35.74  ? 106 TYR C N   1 
ATOM 4392 C CA  . TYR C 3 106 ? 187.388 263.209 345.229 1.00 30.17  ? 106 TYR C CA  1 
ATOM 4393 C C   . TYR C 3 106 ? 187.198 264.067 343.986 1.00 30.83  ? 106 TYR C C   1 
ATOM 4394 O O   . TYR C 3 106 ? 188.179 264.595 343.458 1.00 36.98  ? 106 TYR C O   1 
ATOM 4395 C CB  . TYR C 3 106 ? 188.563 262.255 345.008 1.00 35.35  ? 106 TYR C CB  1 
ATOM 4396 C CG  . TYR C 3 106 ? 189.333 261.936 346.261 1.00 34.09  ? 106 TYR C CG  1 
ATOM 4397 C CD1 . TYR C 3 106 ? 190.068 262.912 346.906 1.00 37.78  ? 106 TYR C CD1 1 
ATOM 4398 C CD2 . TYR C 3 106 ? 189.334 260.661 346.792 1.00 40.32  ? 106 TYR C CD2 1 
ATOM 4399 C CE1 . TYR C 3 106 ? 190.770 262.632 348.047 1.00 43.46  ? 106 TYR C CE1 1 
ATOM 4400 C CE2 . TYR C 3 106 ? 190.037 260.372 347.933 1.00 41.17  ? 106 TYR C CE2 1 
ATOM 4401 C CZ  . TYR C 3 106 ? 190.755 261.361 348.557 1.00 42.41  ? 106 TYR C CZ  1 
ATOM 4402 O OH  . TYR C 3 106 ? 191.461 261.081 349.701 1.00 46.67  ? 106 TYR C OH  1 
ATOM 4403 N N   . TYR C 3 107 ? 185.973 264.210 343.494 1.00 29.85  ? 107 TYR C N   1 
ATOM 4404 C CA  . TYR C 3 107 ? 185.727 264.956 342.272 1.00 17.78  ? 107 TYR C CA  1 
ATOM 4405 C C   . TYR C 3 107 ? 184.436 265.741 342.426 1.00 23.49  ? 107 TYR C C   1 
ATOM 4406 O O   . TYR C 3 107 ? 183.767 265.680 343.461 1.00 31.54  ? 107 TYR C O   1 
ATOM 4407 C CB  . TYR C 3 107 ? 185.681 264.023 341.064 1.00 15.37  ? 107 TYR C CB  1 
ATOM 4408 C CG  . TYR C 3 107 ? 187.027 263.471 340.675 1.00 23.07  ? 107 TYR C CG  1 
ATOM 4409 C CD1 . TYR C 3 107 ? 187.547 262.355 341.300 1.00 27.27  ? 107 TYR C CD1 1 
ATOM 4410 C CD2 . TYR C 3 107 ? 187.775 264.061 339.676 1.00 28.37  ? 107 TYR C CD2 1 
ATOM 4411 C CE1 . TYR C 3 107 ? 188.770 261.847 340.945 1.00 33.66  ? 107 TYR C CE1 1 
ATOM 4412 C CE2 . TYR C 3 107 ? 188.997 263.559 339.313 1.00 24.60  ? 107 TYR C CE2 1 
ATOM 4413 C CZ  . TYR C 3 107 ? 189.492 262.453 339.951 1.00 31.03  ? 107 TYR C CZ  1 
ATOM 4414 O OH  . TYR C 3 107 ? 190.717 261.952 339.590 1.00 30.75  ? 107 TYR C OH  1 
ATOM 4415 N N   . THR C 3 108 ? 184.093 266.500 341.390 1.00 32.91  ? 108 THR C N   1 
ATOM 4416 C CA  . THR C 3 108 ? 182.944 267.395 341.425 1.00 29.34  ? 108 THR C CA  1 
ATOM 4417 C C   . THR C 3 108 ? 181.866 267.033 340.421 1.00 33.02  ? 108 THR C C   1 
ATOM 4418 O O   . THR C 3 108 ? 180.683 267.116 340.749 1.00 37.73  ? 108 THR C O   1 
ATOM 4419 C CB  . THR C 3 108 ? 183.390 268.839 341.177 1.00 24.21  ? 108 THR C CB  1 
ATOM 4420 O OG1 . THR C 3 108 ? 184.576 269.114 341.928 1.00 32.27  ? 108 THR C OG1 1 
ATOM 4421 C CG2 . THR C 3 108 ? 182.305 269.807 341.595 1.00 34.19  ? 108 THR C CG2 1 
ATOM 4422 N N   . HIS C 3 109 ? 182.232 266.643 339.206 1.00 33.32  ? 109 HIS C N   1 
ATOM 4423 C CA  . HIS C 3 109 ? 181.259 266.270 338.192 1.00 28.66  ? 109 HIS C CA  1 
ATOM 4424 C C   . HIS C 3 109 ? 181.407 264.794 337.858 1.00 26.13  ? 109 HIS C C   1 
ATOM 4425 O O   . HIS C 3 109 ? 182.525 264.294 337.731 1.00 36.77  ? 109 HIS C O   1 
ATOM 4426 C CB  . HIS C 3 109 ? 181.435 267.108 336.926 1.00 35.23  ? 109 HIS C CB  1 
ATOM 4427 C CG  . HIS C 3 109 ? 181.483 268.581 337.177 1.00 37.52  ? 109 HIS C CG  1 
ATOM 4428 N ND1 . HIS C 3 109 ? 182.122 269.458 336.329 1.00 30.70  ? 109 HIS C ND1 1 
ATOM 4429 C CD2 . HIS C 3 109 ? 180.972 269.333 338.178 1.00 35.37  ? 109 HIS C CD2 1 
ATOM 4430 C CE1 . HIS C 3 109 ? 182.005 270.685 336.798 1.00 34.20  ? 109 HIS C CE1 1 
ATOM 4431 N NE2 . HIS C 3 109 ? 181.311 270.637 337.920 1.00 32.75  ? 109 HIS C NE2 1 
ATOM 4432 N N   . TRP C 3 110 ? 180.278 264.102 337.716 1.00 31.70  ? 110 TRP C N   1 
ATOM 4433 C CA  . TRP C 3 110 ? 180.265 262.683 337.393 1.00 24.33  ? 110 TRP C CA  1 
ATOM 4434 C C   . TRP C 3 110 ? 179.206 262.412 336.339 1.00 23.18  ? 110 TRP C C   1 
ATOM 4435 O O   . TRP C 3 110 ? 178.244 263.165 336.191 1.00 37.86  ? 110 TRP C O   1 
ATOM 4436 C CB  . TRP C 3 110 ? 179.990 261.819 338.628 1.00 34.96  ? 110 TRP C CB  1 
ATOM 4437 C CG  . TRP C 3 110 ? 178.569 261.855 339.104 1.00 27.09  ? 110 TRP C CG  1 
ATOM 4438 C CD1 . TRP C 3 110 ? 178.034 262.717 340.004 1.00 28.18  ? 110 TRP C CD1 1 
ATOM 4439 C CD2 . TRP C 3 110 ? 177.511 260.977 338.712 1.00 32.61  ? 110 TRP C CD2 1 
ATOM 4440 N NE1 . TRP C 3 110 ? 176.706 262.439 340.197 1.00 30.69  ? 110 TRP C NE1 1 
ATOM 4441 C CE2 . TRP C 3 110 ? 176.362 261.372 339.413 1.00 36.17  ? 110 TRP C CE2 1 
ATOM 4442 C CE3 . TRP C 3 110 ? 177.424 259.895 337.833 1.00 41.67  ? 110 TRP C CE3 1 
ATOM 4443 C CZ2 . TRP C 3 110 ? 175.139 260.727 339.261 1.00 36.33  ? 110 TRP C CZ2 1 
ATOM 4444 C CZ3 . TRP C 3 110 ? 176.211 259.257 337.686 1.00 31.79  ? 110 TRP C CZ3 1 
ATOM 4445 C CH2 . TRP C 3 110 ? 175.087 259.675 338.395 1.00 31.80  ? 110 TRP C CH2 1 
ATOM 4446 N N   . ALA C 3 111 ? 179.386 261.316 335.608 1.00 22.18  ? 111 ALA C N   1 
ATOM 4447 C CA  . ALA C 3 111 ? 178.419 260.958 334.579 1.00 23.19  ? 111 ALA C CA  1 
ATOM 4448 C C   . ALA C 3 111 ? 178.617 259.538 334.067 1.00 26.89  ? 111 ALA C C   1 
ATOM 4449 O O   . ALA C 3 111 ? 179.730 259.159 333.698 1.00 47.50  ? 111 ALA C O   1 
ATOM 4450 C CB  . ALA C 3 111 ? 178.512 261.940 333.417 1.00 34.08  ? 111 ALA C CB  1 
ATOM 4451 N N   . GLY C 3 112 ? 177.550 258.758 334.025 1.00 30.67  ? 112 GLY C N   1 
ATOM 4452 C CA  . GLY C 3 112 ? 177.616 257.421 333.474 1.00 32.35  ? 112 GLY C CA  1 
ATOM 4453 C C   . GLY C 3 112 ? 176.517 256.549 334.037 1.00 42.43  ? 112 GLY C C   1 
ATOM 4454 O O   . GLY C 3 112 ? 175.659 256.997 334.794 1.00 46.01  ? 112 GLY C O   1 
ATOM 4455 N N   . SER C 3 113 ? 176.571 255.279 333.653 1.00 37.40  ? 113 SER C N   1 
ATOM 4456 C CA  . SER C 3 113 ? 175.598 254.292 334.094 1.00 39.08  ? 113 SER C CA  1 
ATOM 4457 C C   . SER C 3 113 ? 176.071 253.598 335.365 1.00 37.70  ? 113 SER C C   1 
ATOM 4458 O O   . SER C 3 113 ? 177.246 253.652 335.729 1.00 45.32  ? 113 SER C O   1 
ATOM 4459 C CB  . SER C 3 113 ? 175.356 253.252 333.003 1.00 41.85  ? 113 SER C CB  1 
ATOM 4460 O OG  . SER C 3 113 ? 174.967 253.863 331.789 1.00 50.45  ? 113 SER C OG  1 
ATOM 4461 N N   . LEU C 3 114 ? 175.135 252.936 336.039 1.00 32.55  ? 114 LEU C N   1 
ATOM 4462 C CA  . LEU C 3 114 ? 175.443 252.137 337.216 1.00 29.67  ? 114 LEU C CA  1 
ATOM 4463 C C   . LEU C 3 114 ? 174.892 250.736 337.018 1.00 41.08  ? 114 LEU C C   1 
ATOM 4464 O O   . LEU C 3 114 ? 174.041 250.507 336.161 1.00 54.34  ? 114 LEU C O   1 
ATOM 4465 C CB  . LEU C 3 114 ? 174.852 252.739 338.492 1.00 29.89  ? 114 LEU C CB  1 
ATOM 4466 C CG  . LEU C 3 114 ? 175.292 254.147 338.874 1.00 36.17  ? 114 LEU C CG  1 
ATOM 4467 C CD1 . LEU C 3 114 ? 174.608 254.571 340.158 1.00 36.33  ? 114 LEU C CD1 1 
ATOM 4468 C CD2 . LEU C 3 114 ? 176.792 254.218 339.023 1.00 41.59  ? 114 LEU C CD2 1 
ATOM 4469 N N   . LYS C 3 115 ? 175.373 249.790 337.820 1.00 40.58  ? 115 LYS C N   1 
ATOM 4470 C CA  . LYS C 3 115 ? 174.830 248.440 337.786 1.00 36.69  ? 115 LYS C CA  1 
ATOM 4471 C C   . LYS C 3 115 ? 174.747 247.887 339.198 1.00 36.55  ? 115 LYS C C   1 
ATOM 4472 O O   . LYS C 3 115 ? 175.730 247.920 339.944 1.00 44.99  ? 115 LYS C O   1 
ATOM 4473 C CB  . LYS C 3 115 ? 175.671 247.530 336.885 1.00 31.45  ? 115 LYS C CB  1 
ATOM 4474 C CG  . LYS C 3 115 ? 176.460 246.443 337.584 1.00 45.67  ? 115 LYS C CG  1 
ATOM 4475 C CD  . LYS C 3 115 ? 177.081 245.483 336.581 1.00 50.34  ? 115 LYS C CD  1 
ATOM 4476 C CE  . LYS C 3 115 ? 177.958 246.198 335.567 1.00 53.63  ? 115 LYS C CE  1 
ATOM 4477 N NZ  . LYS C 3 115 ? 178.652 245.238 334.674 1.00 53.39  ? 115 LYS C NZ  1 
ATOM 4478 N N   . PHE C 3 116 ? 173.569 247.384 339.553 1.00 36.30  ? 116 PHE C N   1 
ATOM 4479 C CA  . PHE C 3 116 ? 173.313 246.774 340.846 1.00 31.31  ? 116 PHE C CA  1 
ATOM 4480 C C   . PHE C 3 116 ? 173.105 245.278 340.674 1.00 41.01  ? 116 PHE C C   1 
ATOM 4481 O O   . PHE C 3 116 ? 172.601 244.816 339.648 1.00 53.35  ? 116 PHE C O   1 
ATOM 4482 C CB  . PHE C 3 116 ? 172.079 247.378 341.515 1.00 24.69  ? 116 PHE C CB  1 
ATOM 4483 C CG  . PHE C 3 116 ? 172.224 248.824 341.863 1.00 39.21  ? 116 PHE C CG  1 
ATOM 4484 C CD1 . PHE C 3 116 ? 172.141 249.795 340.887 1.00 41.24  ? 116 PHE C CD1 1 
ATOM 4485 C CD2 . PHE C 3 116 ? 172.428 249.216 343.170 1.00 42.06  ? 116 PHE C CD2 1 
ATOM 4486 C CE1 . PHE C 3 116 ? 172.270 251.124 341.206 1.00 38.44  ? 116 PHE C CE1 1 
ATOM 4487 C CE2 . PHE C 3 116 ? 172.556 250.546 343.493 1.00 40.54  ? 116 PHE C CE2 1 
ATOM 4488 C CZ  . PHE C 3 116 ? 172.476 251.501 342.510 1.00 34.78  ? 116 PHE C CZ  1 
ATOM 4489 N N   . THR C 3 117 ? 173.513 244.524 341.686 1.00 38.24  ? 117 THR C N   1 
ATOM 4490 C CA  . THR C 3 117 ? 173.338 243.082 341.714 1.00 37.98  ? 117 THR C CA  1 
ATOM 4491 C C   . THR C 3 117 ? 172.815 242.692 343.085 1.00 41.87  ? 117 THR C C   1 
ATOM 4492 O O   . THR C 3 117 ? 173.297 243.198 344.099 1.00 38.24  ? 117 THR C O   1 
ATOM 4493 C CB  . THR C 3 117 ? 174.653 242.359 341.417 1.00 40.81  ? 117 THR C CB  1 
ATOM 4494 O OG1 . THR C 3 117 ? 175.212 242.863 340.200 1.00 45.44  ? 117 THR C OG1 1 
ATOM 4495 C CG2 . THR C 3 117 ? 174.423 240.869 341.278 1.00 43.15  ? 117 THR C CG2 1 
ATOM 4496 N N   . PHE C 3 118 ? 171.825 241.811 343.115 1.00 38.27  ? 118 PHE C N   1 
ATOM 4497 C CA  . PHE C 3 118 ? 171.286 241.283 344.357 1.00 32.35  ? 118 PHE C CA  1 
ATOM 4498 C C   . PHE C 3 118 ? 171.500 239.782 344.381 1.00 38.18  ? 118 PHE C C   1 
ATOM 4499 O O   . PHE C 3 118 ? 171.328 239.110 343.362 1.00 50.03  ? 118 PHE C O   1 
ATOM 4500 C CB  . PHE C 3 118 ? 169.805 241.610 344.509 1.00 40.14  ? 118 PHE C CB  1 
ATOM 4501 C CG  . PHE C 3 118 ? 169.513 243.078 344.513 1.00 45.69  ? 118 PHE C CG  1 
ATOM 4502 C CD1 . PHE C 3 118 ? 169.676 243.822 345.660 1.00 43.52  ? 118 PHE C CD1 1 
ATOM 4503 C CD2 . PHE C 3 118 ? 169.078 243.711 343.369 1.00 38.45  ? 118 PHE C CD2 1 
ATOM 4504 C CE1 . PHE C 3 118 ? 169.418 245.164 345.665 1.00 35.62  ? 118 PHE C CE1 1 
ATOM 4505 C CE2 . PHE C 3 118 ? 168.815 245.054 343.370 1.00 42.61  ? 118 PHE C CE2 1 
ATOM 4506 C CZ  . PHE C 3 118 ? 168.984 245.782 344.520 1.00 40.40  ? 118 PHE C CZ  1 
ATOM 4507 N N   . MET C 3 119 ? 171.894 239.268 345.541 1.00 43.68  ? 119 MET C N   1 
ATOM 4508 C CA  . MET C 3 119 ? 172.229 237.862 345.709 1.00 40.91  ? 119 MET C CA  1 
ATOM 4509 C C   . MET C 3 119 ? 171.390 237.282 346.833 1.00 49.08  ? 119 MET C C   1 
ATOM 4510 O O   . MET C 3 119 ? 171.325 237.859 347.923 1.00 53.46  ? 119 MET C O   1 
ATOM 4511 C CB  . MET C 3 119 ? 173.717 237.688 346.012 1.00 42.39  ? 119 MET C CB  1 
ATOM 4512 C CG  . MET C 3 119 ? 174.132 236.266 346.326 1.00 45.57  ? 119 MET C CG  1 
ATOM 4513 S SD  . MET C 3 119 ? 175.886 236.124 346.699 1.00 56.43  ? 119 MET C SD  1 
ATOM 4514 C CE  . MET C 3 119 ? 176.598 236.522 345.109 1.00 43.99  ? 119 MET C CE  1 
ATOM 4515 N N   . PHE C 3 120 ? 170.765 236.138 346.568 1.00 40.08  ? 120 PHE C N   1 
ATOM 4516 C CA  . PHE C 3 120 ? 169.891 235.465 347.519 1.00 37.24  ? 120 PHE C CA  1 
ATOM 4517 C C   . PHE C 3 120 ? 170.683 234.368 348.218 1.00 42.68  ? 120 PHE C C   1 
ATOM 4518 O O   . PHE C 3 120 ? 171.230 233.478 347.560 1.00 49.20  ? 120 PHE C O   1 
ATOM 4519 C CB  . PHE C 3 120 ? 168.670 234.887 346.804 1.00 44.11  ? 120 PHE C CB  1 
ATOM 4520 C CG  . PHE C 3 120 ? 167.669 234.253 347.723 1.00 36.26  ? 120 PHE C CG  1 
ATOM 4521 C CD1 . PHE C 3 120 ? 166.888 235.027 348.555 1.00 38.04  ? 120 PHE C CD1 1 
ATOM 4522 C CD2 . PHE C 3 120 ? 167.499 232.886 347.742 1.00 34.77  ? 120 PHE C CD2 1 
ATOM 4523 C CE1 . PHE C 3 120 ? 165.970 234.448 349.394 1.00 38.75  ? 120 PHE C CE1 1 
ATOM 4524 C CE2 . PHE C 3 120 ? 166.582 232.303 348.579 1.00 39.89  ? 120 PHE C CE2 1 
ATOM 4525 C CZ  . PHE C 3 120 ? 165.816 233.084 349.405 1.00 41.54  ? 120 PHE C CZ  1 
ATOM 4526 N N   . CYS C 3 121 ? 170.747 234.435 349.545 1.00 42.06  ? 121 CYS C N   1 
ATOM 4527 C CA  . CYS C 3 121 ? 171.536 233.511 350.352 1.00 37.84  ? 121 CYS C CA  1 
ATOM 4528 C C   . CYS C 3 121 ? 170.643 232.634 351.224 1.00 46.84  ? 121 CYS C C   1 
ATOM 4529 O O   . CYS C 3 121 ? 170.948 232.371 352.387 1.00 49.58  ? 121 CYS C O   1 
ATOM 4530 C CB  . CYS C 3 121 ? 172.535 234.271 351.219 1.00 45.60  ? 121 CYS C CB  1 
ATOM 4531 S SG  . CYS C 3 121 ? 173.728 235.263 350.294 1.00 60.38  ? 121 CYS C SG  1 
ATOM 4532 N N   . GLY C 3 122 ? 169.526 232.181 350.668 1.00 51.48  ? 122 GLY C N   1 
ATOM 4533 C CA  . GLY C 3 122 ? 168.619 231.284 351.344 1.00 46.27  ? 122 GLY C CA  1 
ATOM 4534 C C   . GLY C 3 122 ? 168.883 229.834 351.001 1.00 44.46  ? 122 GLY C C   1 
ATOM 4535 O O   . GLY C 3 122 ? 169.937 229.470 350.468 1.00 48.48  ? 122 GLY C O   1 
ATOM 4536 N N   . SER C 3 123 ? 167.901 228.992 351.301 1.00 44.73  ? 123 SER C N   1 
ATOM 4537 C CA  . SER C 3 123 ? 168.046 227.560 351.111 1.00 42.44  ? 123 SER C CA  1 
ATOM 4538 C C   . SER C 3 123 ? 167.911 227.190 349.640 1.00 42.95  ? 123 SER C C   1 
ATOM 4539 O O   . SER C 3 123 ? 167.398 227.952 348.821 1.00 42.15  ? 123 SER C O   1 
ATOM 4540 C CB  . SER C 3 123 ? 167.005 226.803 351.929 1.00 44.71  ? 123 SER C CB  1 
ATOM 4541 O OG  . SER C 3 123 ? 167.178 225.406 351.798 1.00 48.89  ? 123 SER C OG  1 
ATOM 4542 N N   . MET C 3 124 ? 168.395 225.995 349.308 1.00 54.43  ? 124 MET C N   1 
ATOM 4543 C CA  . MET C 3 124 ? 168.240 225.480 347.955 1.00 53.89  ? 124 MET C CA  1 
ATOM 4544 C C   . MET C 3 124 ? 166.826 224.984 347.691 1.00 56.66  ? 124 MET C C   1 
ATOM 4545 O O   . MET C 3 124 ? 166.452 224.806 346.529 1.00 57.94  ? 124 MET C O   1 
ATOM 4546 C CB  . MET C 3 124 ? 169.242 224.350 347.712 1.00 50.97  ? 124 MET C CB  1 
ATOM 4547 C CG  . MET C 3 124 ? 169.176 223.739 346.323 1.00 53.32  ? 124 MET C CG  1 
ATOM 4548 S SD  . MET C 3 124 ? 170.337 222.383 346.100 1.00 75.32  ? 124 MET C SD  1 
ATOM 4549 C CE  . MET C 3 124 ? 171.901 223.239 346.242 1.00 59.09  ? 124 MET C CE  1 
ATOM 4550 N N   . MET C 3 125 ? 166.036 224.762 348.738 1.00 50.89  ? 125 MET C N   1 
ATOM 4551 C CA  . MET C 3 125 ? 164.699 224.203 348.613 1.00 47.76  ? 125 MET C CA  1 
ATOM 4552 C C   . MET C 3 125 ? 163.603 225.258 348.667 1.00 47.20  ? 125 MET C C   1 
ATOM 4553 O O   . MET C 3 125 ? 162.422 224.901 348.694 1.00 51.31  ? 125 MET C O   1 
ATOM 4554 C CB  . MET C 3 125 ? 164.468 223.167 349.712 1.00 57.28  ? 125 MET C CB  1 
ATOM 4555 C CG  . MET C 3 125 ? 165.430 221.994 349.681 1.00 53.08  ? 125 MET C CG  1 
ATOM 4556 S SD  . MET C 3 125 ? 165.115 220.885 348.301 1.00 62.88  ? 125 MET C SD  1 
ATOM 4557 C CE  . MET C 3 125 ? 166.595 219.886 348.332 1.00 57.34  ? 125 MET C CE  1 
ATOM 4558 N N   . ALA C 3 126 ? 163.957 226.539 348.687 1.00 46.75  ? 126 ALA C N   1 
ATOM 4559 C CA  . ALA C 3 126 ? 162.976 227.613 348.735 1.00 41.35  ? 126 ALA C CA  1 
ATOM 4560 C C   . ALA C 3 126 ? 162.575 228.041 347.328 1.00 47.33  ? 126 ALA C C   1 
ATOM 4561 O O   . ALA C 3 126 ? 163.334 227.881 346.370 1.00 50.60  ? 126 ALA C O   1 
ATOM 4562 C CB  . ALA C 3 126 ? 163.527 228.813 349.502 1.00 41.05  ? 126 ALA C CB  1 
ATOM 4563 N N   . THR C 3 127 ? 161.366 228.592 347.215 1.00 47.85  ? 127 THR C N   1 
ATOM 4564 C CA  . THR C 3 127 ? 160.826 229.046 345.942 1.00 47.61  ? 127 THR C CA  1 
ATOM 4565 C C   . THR C 3 127 ? 160.032 230.326 346.159 1.00 51.41  ? 127 THR C C   1 
ATOM 4566 O O   . THR C 3 127 ? 159.455 230.538 347.226 1.00 48.01  ? 127 THR C O   1 
ATOM 4567 C CB  . THR C 3 127 ? 159.920 227.990 345.301 1.00 52.41  ? 127 THR C CB  1 
ATOM 4568 O OG1 . THR C 3 127 ? 160.435 226.683 345.574 1.00 52.29  ? 127 THR C OG1 1 
ATOM 4569 C CG2 . THR C 3 127 ? 159.843 228.194 343.798 1.00 52.62  ? 127 THR C CG2 1 
ATOM 4570 N N   . GLY C 3 128 ? 160.002 231.173 345.138 1.00 45.60  ? 128 GLY C N   1 
ATOM 4571 C CA  . GLY C 3 128 ? 159.245 232.407 345.225 1.00 34.67  ? 128 GLY C CA  1 
ATOM 4572 C C   . GLY C 3 128 ? 159.640 233.362 344.121 1.00 38.53  ? 128 GLY C C   1 
ATOM 4573 O O   . GLY C 3 128 ? 160.487 233.062 343.279 1.00 44.92  ? 128 GLY C O   1 
ATOM 4574 N N   . LYS C 3 129 ? 159.008 234.534 344.148 1.00 43.02  ? 129 LYS C N   1 
ATOM 4575 C CA  . LYS C 3 129 ? 159.244 235.562 343.143 1.00 41.50  ? 129 LYS C CA  1 
ATOM 4576 C C   . LYS C 3 129 ? 159.356 236.925 343.805 1.00 43.03  ? 129 LYS C C   1 
ATOM 4577 O O   . LYS C 3 129 ? 158.617 237.231 344.742 1.00 45.24  ? 129 LYS C O   1 
ATOM 4578 C CB  . LYS C 3 129 ? 158.122 235.594 342.103 1.00 42.69  ? 129 LYS C CB  1 
ATOM 4579 C CG  . LYS C 3 129 ? 158.125 234.423 341.150 1.00 42.70  ? 129 LYS C CG  1 
ATOM 4580 C CD  . LYS C 3 129 ? 156.872 234.411 340.303 1.00 48.34  ? 129 LYS C CD  1 
ATOM 4581 C CE  . LYS C 3 129 ? 156.891 233.282 339.293 1.00 48.97  ? 129 LYS C CE  1 
ATOM 4582 N NZ  . LYS C 3 129 ? 157.918 233.505 338.245 1.00 51.38  ? 129 LYS C NZ  1 
ATOM 4583 N N   . LEU C 3 130 ? 160.280 237.742 343.303 1.00 42.66  ? 130 LEU C N   1 
ATOM 4584 C CA  . LEU C 3 130 ? 160.469 239.111 343.755 1.00 40.69  ? 130 LEU C CA  1 
ATOM 4585 C C   . LEU C 3 130 ? 160.398 240.035 342.552 1.00 41.35  ? 130 LEU C C   1 
ATOM 4586 O O   . LEU C 3 130 ? 160.668 239.623 341.425 1.00 47.22  ? 130 LEU C O   1 
ATOM 4587 C CB  . LEU C 3 130 ? 161.811 239.292 344.468 1.00 40.87  ? 130 LEU C CB  1 
ATOM 4588 C CG  . LEU C 3 130 ? 162.061 238.404 345.683 1.00 41.11  ? 130 LEU C CG  1 
ATOM 4589 C CD1 . LEU C 3 130 ? 163.432 238.681 346.250 1.00 37.88  ? 130 LEU C CD1 1 
ATOM 4590 C CD2 . LEU C 3 130 ? 160.998 238.611 346.741 1.00 46.08  ? 130 LEU C CD2 1 
ATOM 4591 N N   . LEU C 3 131 ? 160.028 241.287 342.792 1.00 39.72  ? 131 LEU C N   1 
ATOM 4592 C CA  . LEU C 3 131 ? 159.869 242.272 341.729 1.00 43.53  ? 131 LEU C CA  1 
ATOM 4593 C C   . LEU C 3 131 ? 160.858 243.401 341.966 1.00 45.36  ? 131 LEU C C   1 
ATOM 4594 O O   . LEU C 3 131 ? 160.786 244.080 342.992 1.00 50.15  ? 131 LEU C O   1 
ATOM 4595 C CB  . LEU C 3 131 ? 158.432 242.797 341.696 1.00 49.00  ? 131 LEU C CB  1 
ATOM 4596 C CG  . LEU C 3 131 ? 158.062 243.854 340.657 1.00 47.36  ? 131 LEU C CG  1 
ATOM 4597 C CD1 . LEU C 3 131 ? 156.641 243.636 340.193 1.00 44.94  ? 131 LEU C CD1 1 
ATOM 4598 C CD2 . LEU C 3 131 ? 158.216 245.249 341.229 1.00 49.38  ? 131 LEU C CD2 1 
ATOM 4599 N N   . VAL C 3 132 ? 161.781 243.598 341.029 1.00 41.15  ? 132 VAL C N   1 
ATOM 4600 C CA  . VAL C 3 132 ? 162.796 244.640 341.135 1.00 41.54  ? 132 VAL C CA  1 
ATOM 4601 C C   . VAL C 3 132 ? 162.451 245.721 340.124 1.00 45.52  ? 132 VAL C C   1 
ATOM 4602 O O   . VAL C 3 132 ? 162.476 245.473 338.913 1.00 47.88  ? 132 VAL C O   1 
ATOM 4603 C CB  . VAL C 3 132 ? 164.206 244.084 340.892 1.00 41.54  ? 132 VAL C CB  1 
ATOM 4604 C CG1 . VAL C 3 132 ? 165.242 245.173 341.071 1.00 39.70  ? 132 VAL C CG1 1 
ATOM 4605 C CG2 . VAL C 3 132 ? 164.482 242.927 341.829 1.00 43.16  ? 132 VAL C CG2 1 
ATOM 4606 N N   . SER C 3 133 ? 162.143 246.919 340.616 1.00 43.64  ? 133 SER C N   1 
ATOM 4607 C CA  . SER C 3 133 ? 161.620 247.994 339.787 1.00 37.35  ? 133 SER C CA  1 
ATOM 4608 C C   . SER C 3 133 ? 162.512 249.222 339.864 1.00 36.66  ? 133 SER C C   1 
ATOM 4609 O O   . SER C 3 133 ? 163.087 249.530 340.912 1.00 46.40  ? 133 SER C O   1 
ATOM 4610 C CB  . SER C 3 133 ? 160.207 248.373 340.211 1.00 45.72  ? 133 SER C CB  1 
ATOM 4611 O OG  . SER C 3 133 ? 160.193 248.850 341.541 1.00 49.84  ? 133 SER C OG  1 
ATOM 4612 N N   . TYR C 3 134 ? 162.605 249.932 338.739 1.00 43.07  ? 134 TYR C N   1 
ATOM 4613 C CA  . TYR C 3 134 ? 163.428 251.130 338.618 1.00 42.39  ? 134 TYR C CA  1 
ATOM 4614 C C   . TYR C 3 134 ? 162.539 252.324 338.305 1.00 41.07  ? 134 TYR C C   1 
ATOM 4615 O O   . TYR C 3 134 ? 161.820 252.318 337.302 1.00 48.94  ? 134 TYR C O   1 
ATOM 4616 C CB  . TYR C 3 134 ? 164.486 250.951 337.529 1.00 37.63  ? 134 TYR C CB  1 
ATOM 4617 C CG  . TYR C 3 134 ? 165.072 252.242 337.018 1.00 44.05  ? 134 TYR C CG  1 
ATOM 4618 C CD1 . TYR C 3 134 ? 165.755 253.099 337.865 1.00 49.02  ? 134 TYR C CD1 1 
ATOM 4619 C CD2 . TYR C 3 134 ? 164.958 252.598 335.687 1.00 44.70  ? 134 TYR C CD2 1 
ATOM 4620 C CE1 . TYR C 3 134 ? 166.295 254.277 337.401 1.00 46.33  ? 134 TYR C CE1 1 
ATOM 4621 C CE2 . TYR C 3 134 ? 165.495 253.773 335.214 1.00 46.44  ? 134 TYR C CE2 1 
ATOM 4622 C CZ  . TYR C 3 134 ? 166.163 254.608 336.074 1.00 47.55  ? 134 TYR C CZ  1 
ATOM 4623 O OH  . TYR C 3 134 ? 166.703 255.780 335.608 1.00 48.87  ? 134 TYR C OH  1 
ATOM 4624 N N   . ALA C 3 135 ? 162.596 253.347 339.157 1.00 42.36  ? 135 ALA C N   1 
ATOM 4625 C CA  . ALA C 3 135 ? 161.817 254.562 338.960 1.00 45.18  ? 135 ALA C CA  1 
ATOM 4626 C C   . ALA C 3 135 ? 162.716 255.652 338.404 1.00 44.81  ? 135 ALA C C   1 
ATOM 4627 O O   . ALA C 3 135 ? 163.716 255.994 339.053 1.00 55.31  ? 135 ALA C O   1 
ATOM 4628 C CB  . ALA C 3 135 ? 161.191 255.019 340.269 1.00 44.72  ? 135 ALA C CB  1 
ATOM 4629 N N   . PRO C 3 136 ? 162.416 256.227 337.243 1.00 45.99  ? 136 PRO C N   1 
ATOM 4630 C CA  . PRO C 3 136 ? 163.350 257.163 336.613 1.00 52.43  ? 136 PRO C CA  1 
ATOM 4631 C C   . PRO C 3 136 ? 163.390 258.490 337.347 1.00 53.18  ? 136 PRO C C   1 
ATOM 4632 O O   . PRO C 3 136 ? 162.609 258.717 338.283 1.00 53.27  ? 136 PRO C O   1 
ATOM 4633 C CB  . PRO C 3 136 ? 162.781 257.324 335.197 1.00 51.44  ? 136 PRO C CB  1 
ATOM 4634 C CG  . PRO C 3 136 ? 161.341 257.064 335.353 1.00 49.44  ? 136 PRO C CG  1 
ATOM 4635 C CD  . PRO C 3 136 ? 161.211 256.027 336.420 1.00 49.16  ? 136 PRO C CD  1 
ATOM 4636 N N   . PRO C 3 137 ? 164.288 259.393 336.954 1.00 48.60  ? 137 PRO C N   1 
ATOM 4637 C CA  . PRO C 3 137 ? 164.407 260.669 337.662 1.00 45.29  ? 137 PRO C CA  1 
ATOM 4638 C C   . PRO C 3 137 ? 163.136 261.495 337.552 1.00 48.91  ? 137 PRO C C   1 
ATOM 4639 O O   . PRO C 3 137 ? 162.415 261.440 336.555 1.00 54.08  ? 137 PRO C O   1 
ATOM 4640 C CB  . PRO C 3 137 ? 165.583 261.359 336.961 1.00 49.46  ? 137 PRO C CB  1 
ATOM 4641 C CG  . PRO C 3 137 ? 166.300 260.282 336.240 1.00 46.71  ? 137 PRO C CG  1 
ATOM 4642 C CD  . PRO C 3 137 ? 165.268 259.278 335.865 1.00 47.72  ? 137 PRO C CD  1 
ATOM 4643 N N   . GLY C 3 138 ? 162.870 262.273 338.596 1.00 52.76  ? 138 GLY C N   1 
ATOM 4644 C CA  . GLY C 3 138 ? 161.710 263.135 338.627 1.00 50.98  ? 138 GLY C CA  1 
ATOM 4645 C C   . GLY C 3 138 ? 160.422 262.469 339.051 1.00 54.01  ? 138 GLY C C   1 
ATOM 4646 O O   . GLY C 3 138 ? 159.391 263.149 339.118 1.00 52.03  ? 138 GLY C O   1 
ATOM 4647 N N   . ALA C 3 139 ? 160.439 261.173 339.341 1.00 61.62  ? 139 ALA C N   1 
ATOM 4648 C CA  . ALA C 3 139 ? 159.257 260.438 339.770 1.00 58.54  ? 139 ALA C CA  1 
ATOM 4649 C C   . ALA C 3 139 ? 159.450 259.961 341.201 1.00 61.48  ? 139 ALA C C   1 
ATOM 4650 O O   . ALA C 3 139 ? 160.465 259.334 341.519 1.00 60.45  ? 139 ALA C O   1 
ATOM 4651 C CB  . ALA C 3 139 ? 158.994 259.248 338.848 1.00 56.56  ? 139 ALA C CB  1 
ATOM 4652 N N   . ASP C 3 140 ? 158.477 260.254 342.058 1.00 63.70  ? 140 ASP C N   1 
ATOM 4653 C CA  . ASP C 3 140 ? 158.544 259.797 343.434 1.00 61.73  ? 140 ASP C CA  1 
ATOM 4654 C C   . ASP C 3 140 ? 158.466 258.271 343.485 1.00 68.60  ? 140 ASP C C   1 
ATOM 4655 O O   . ASP C 3 140 ? 157.931 257.639 342.571 1.00 66.59  ? 140 ASP C O   1 
ATOM 4656 C CB  . ASP C 3 140 ? 157.417 260.411 344.258 1.00 64.85  ? 140 ASP C CB  1 
ATOM 4657 C CG  . ASP C 3 140 ? 156.073 260.320 343.568 1.00 71.95  ? 140 ASP C CG  1 
ATOM 4658 O OD1 . ASP C 3 140 ? 156.011 259.742 342.463 1.00 73.78  ? 140 ASP C OD1 1 
ATOM 4659 O OD2 . ASP C 3 140 ? 155.081 260.834 344.127 1.00 67.35  ? 140 ASP C OD2 1 
ATOM 4660 N N   . PRO C 3 141 ? 159.005 257.655 344.539 1.00 67.83  ? 141 PRO C N   1 
ATOM 4661 C CA  . PRO C 3 141 ? 159.114 256.201 344.551 1.00 60.46  ? 141 PRO C CA  1 
ATOM 4662 C C   . PRO C 3 141 ? 157.745 255.549 344.577 1.00 59.66  ? 141 PRO C C   1 
ATOM 4663 O O   . PRO C 3 141 ? 156.788 256.104 345.143 1.00 64.15  ? 141 PRO C O   1 
ATOM 4664 C CB  . PRO C 3 141 ? 159.894 255.917 345.846 1.00 59.10  ? 141 PRO C CB  1 
ATOM 4665 C CG  . PRO C 3 141 ? 159.598 257.064 346.710 1.00 58.76  ? 141 PRO C CG  1 
ATOM 4666 C CD  . PRO C 3 141 ? 159.484 258.246 345.800 1.00 65.00  ? 141 PRO C CD  1 
ATOM 4667 N N   . PRO C 3 142 ? 157.600 254.369 343.981 1.00 53.11  ? 142 PRO C N   1 
ATOM 4668 C CA  . PRO C 3 142 ? 156.332 253.646 344.081 1.00 55.33  ? 142 PRO C CA  1 
ATOM 4669 C C   . PRO C 3 142 ? 156.119 253.086 345.478 1.00 55.24  ? 142 PRO C C   1 
ATOM 4670 O O   . PRO C 3 142 ? 157.060 252.844 346.235 1.00 51.78  ? 142 PRO C O   1 
ATOM 4671 C CB  . PRO C 3 142 ? 156.477 252.530 343.046 1.00 53.66  ? 142 PRO C CB  1 
ATOM 4672 C CG  . PRO C 3 142 ? 157.926 252.316 342.934 1.00 57.55  ? 142 PRO C CG  1 
ATOM 4673 C CD  . PRO C 3 142 ? 158.574 253.647 343.149 1.00 59.61  ? 142 PRO C CD  1 
ATOM 4674 N N   . LYS C 3 143 ? 154.845 252.878 345.812 1.00 63.34  ? 143 LYS C N   1 
ATOM 4675 C CA  . LYS C 3 143 ? 154.455 252.434 347.140 1.00 65.27  ? 143 LYS C CA  1 
ATOM 4676 C C   . LYS C 3 143 ? 153.654 251.143 347.154 1.00 63.52  ? 143 LYS C C   1 
ATOM 4677 O O   . LYS C 3 143 ? 153.438 250.587 348.236 1.00 58.65  ? 143 LYS C O   1 
ATOM 4678 C CB  . LYS C 3 143 ? 153.637 253.527 347.842 1.00 62.44  ? 143 LYS C CB  1 
ATOM 4679 C CG  . LYS C 3 143 ? 154.392 254.828 348.013 1.00 61.63  ? 143 LYS C CG  1 
ATOM 4680 C CD  . LYS C 3 143 ? 153.504 255.919 348.576 1.00 63.90  ? 143 LYS C CD  1 
ATOM 4681 C CE  . LYS C 3 143 ? 154.292 257.190 348.821 1.00 67.22  ? 143 LYS C CE  1 
ATOM 4682 N NZ  . LYS C 3 143 ? 154.960 257.678 347.584 1.00 70.29  ? 143 LYS C NZ  1 
ATOM 4683 N N   . LYS C 3 144 ? 153.201 250.654 346.004 1.00 66.72  ? 144 LYS C N   1 
ATOM 4684 C CA  . LYS C 3 144 ? 152.461 249.405 345.932 1.00 65.83  ? 144 LYS C CA  1 
ATOM 4685 C C   . LYS C 3 144 ? 152.985 248.595 344.759 1.00 65.46  ? 144 LYS C C   1 
ATOM 4686 O O   . LYS C 3 144 ? 153.489 249.148 343.780 1.00 64.73  ? 144 LYS C O   1 
ATOM 4687 C CB  . LYS C 3 144 ? 150.955 249.649 345.781 1.00 68.18  ? 144 LYS C CB  1 
ATOM 4688 C CG  . LYS C 3 144 ? 150.356 250.512 346.881 1.00 68.25  ? 144 LYS C CG  1 
ATOM 4689 C CD  . LYS C 3 144 ? 150.434 249.831 348.241 1.00 72.47  ? 144 LYS C CD  1 
ATOM 4690 C CE  . LYS C 3 144 ? 150.095 250.792 349.366 1.00 71.12  ? 144 LYS C CE  1 
ATOM 4691 N NZ  . LYS C 3 144 ? 150.342 250.193 350.706 1.00 68.41  ? 144 LYS C NZ  1 
ATOM 4692 N N   . ARG C 3 145 ? 152.859 247.272 344.866 1.00 57.24  ? 145 ARG C N   1 
ATOM 4693 C CA  . ARG C 3 145 ? 153.423 246.401 343.843 1.00 55.69  ? 145 ARG C CA  1 
ATOM 4694 C C   . ARG C 3 145 ? 152.788 246.646 342.484 1.00 59.55  ? 145 ARG C C   1 
ATOM 4695 O O   . ARG C 3 145 ? 153.456 246.501 341.456 1.00 61.61  ? 145 ARG C O   1 
ATOM 4696 C CB  . ARG C 3 145 ? 153.251 244.939 344.242 1.00 58.11  ? 145 ARG C CB  1 
ATOM 4697 C CG  . ARG C 3 145 ? 154.115 243.987 343.440 1.00 57.40  ? 145 ARG C CG  1 
ATOM 4698 C CD  . ARG C 3 145 ? 153.443 242.644 343.225 1.00 55.95  ? 145 ARG C CD  1 
ATOM 4699 N NE  . ARG C 3 145 ? 152.430 242.699 342.179 1.00 52.46  ? 145 ARG C NE  1 
ATOM 4700 C CZ  . ARG C 3 145 ? 151.131 242.859 342.388 1.00 54.59  ? 145 ARG C CZ  1 
ATOM 4701 N NH1 . ARG C 3 145 ? 150.630 242.960 343.608 1.00 55.06  ? 145 ARG C NH1 1 
ATOM 4702 N NH2 . ARG C 3 145 ? 150.311 242.919 341.343 1.00 55.57  ? 145 ARG C NH2 1 
ATOM 4703 N N   . LYS C 3 146 ? 151.502 246.998 342.451 1.00 62.88  ? 146 LYS C N   1 
ATOM 4704 C CA  . LYS C 3 146 ? 150.850 247.257 341.172 1.00 58.73  ? 146 LYS C CA  1 
ATOM 4705 C C   . LYS C 3 146 ? 151.430 248.493 340.498 1.00 59.86  ? 146 LYS C C   1 
ATOM 4706 O O   . LYS C 3 146 ? 151.633 248.502 339.280 1.00 59.88  ? 146 LYS C O   1 
ATOM 4707 C CB  . LYS C 3 146 ? 149.346 247.413 341.370 1.00 60.79  ? 146 LYS C CB  1 
ATOM 4708 C CG  . LYS C 3 146 ? 148.559 247.427 340.070 1.00 61.23  ? 146 LYS C CG  1 
ATOM 4709 C CD  . LYS C 3 146 ? 147.067 247.518 340.323 1.00 63.33  ? 146 LYS C CD  1 
ATOM 4710 C CE  . LYS C 3 146 ? 146.276 247.397 339.036 1.00 61.62  ? 146 LYS C CE  1 
ATOM 4711 N NZ  . LYS C 3 146 ? 146.639 248.452 338.056 1.00 65.63  ? 146 LYS C NZ  1 
ATOM 4712 N N   . GLU C 3 147 ? 151.706 249.544 341.271 1.00 58.52  ? 147 GLU C N   1 
ATOM 4713 C CA  . GLU C 3 147 ? 152.323 250.731 340.692 1.00 58.49  ? 147 GLU C CA  1 
ATOM 4714 C C   . GLU C 3 147 ? 153.678 250.398 340.087 1.00 64.84  ? 147 GLU C C   1 
ATOM 4715 O O   . GLU C 3 147 ? 154.009 250.860 338.989 1.00 68.11  ? 147 GLU C O   1 
ATOM 4716 C CB  . GLU C 3 147 ? 152.477 251.818 341.752 1.00 59.90  ? 147 GLU C CB  1 
ATOM 4717 C CG  . GLU C 3 147 ? 151.189 252.203 342.446 1.00 68.01  ? 147 GLU C CG  1 
ATOM 4718 C CD  . GLU C 3 147 ? 151.386 253.322 343.449 1.00 68.94  ? 147 GLU C CD  1 
ATOM 4719 O OE1 . GLU C 3 147 ? 152.465 253.950 343.439 1.00 60.67  ? 147 GLU C OE1 1 
ATOM 4720 O OE2 . GLU C 3 147 ? 150.463 253.572 344.251 1.00 69.11  ? 147 GLU C OE2 1 
ATOM 4721 N N   . ALA C 3 148 ? 154.478 249.597 340.790 1.00 53.22  ? 148 ALA C N   1 
ATOM 4722 C CA  . ALA C 3 148 ? 155.795 249.241 340.285 1.00 47.73  ? 148 ALA C CA  1 
ATOM 4723 C C   . ALA C 3 148 ? 155.706 248.303 339.093 1.00 52.45  ? 148 ALA C C   1 
ATOM 4724 O O   . ALA C 3 148 ? 156.601 248.301 338.242 1.00 56.48  ? 148 ALA C O   1 
ATOM 4725 C CB  . ALA C 3 148 ? 156.622 248.602 341.395 1.00 51.70  ? 148 ALA C CB  1 
ATOM 4726 N N   . MET C 3 149 ? 154.649 247.495 339.016 1.00 55.99  ? 149 MET C N   1 
ATOM 4727 C CA  . MET C 3 149 ? 154.515 246.564 337.902 1.00 54.33  ? 149 MET C CA  1 
ATOM 4728 C C   . MET C 3 149 ? 154.301 247.295 336.585 1.00 57.08  ? 149 MET C C   1 
ATOM 4729 O O   . MET C 3 149 ? 154.715 246.801 335.532 1.00 57.27  ? 149 MET C O   1 
ATOM 4730 C CB  . MET C 3 149 ? 153.361 245.601 338.168 1.00 57.35  ? 149 MET C CB  1 
ATOM 4731 C CG  . MET C 3 149 ? 153.240 244.471 337.155 1.00 58.82  ? 149 MET C CG  1 
ATOM 4732 S SD  . MET C 3 149 ? 152.303 244.895 335.674 1.00 70.30  ? 149 MET C SD  1 
ATOM 4733 C CE  . MET C 3 149 ? 150.659 245.100 336.350 1.00 55.80  ? 149 MET C CE  1 
ATOM 4734 N N   . LEU C 3 150 ? 153.661 248.461 336.620 1.00 60.31  ? 150 LEU C N   1 
ATOM 4735 C CA  . LEU C 3 150 ? 153.367 249.219 335.412 1.00 57.83  ? 150 LEU C CA  1 
ATOM 4736 C C   . LEU C 3 150 ? 154.560 250.014 334.902 1.00 56.42  ? 150 LEU C C   1 
ATOM 4737 O O   . LEU C 3 150 ? 154.490 250.557 333.796 1.00 61.86  ? 150 LEU C O   1 
ATOM 4738 C CB  . LEU C 3 150 ? 152.195 250.166 335.669 1.00 56.85  ? 150 LEU C CB  1 
ATOM 4739 C CG  . LEU C 3 150 ? 150.879 249.474 336.017 1.00 59.21  ? 150 LEU C CG  1 
ATOM 4740 C CD1 . LEU C 3 150 ? 149.890 250.468 336.581 1.00 62.87  ? 150 LEU C CD1 1 
ATOM 4741 C CD2 . LEU C 3 150 ? 150.301 248.781 334.796 1.00 56.41  ? 150 LEU C CD2 1 
ATOM 4742 N N   . GLY C 3 151 ? 155.637 250.098 335.665 1.00 55.97  ? 151 GLY C N   1 
ATOM 4743 C CA  . GLY C 3 151 ? 156.848 250.767 335.251 1.00 58.62  ? 151 GLY C CA  1 
ATOM 4744 C C   . GLY C 3 151 ? 157.825 249.815 334.599 1.00 55.75  ? 151 GLY C C   1 
ATOM 4745 O O   . GLY C 3 151 ? 157.437 248.827 333.968 1.00 60.44  ? 151 GLY C O   1 
ATOM 4746 N N   . THR C 3 152 ? 159.111 250.119 334.740 1.00 47.12  ? 152 THR C N   1 
ATOM 4747 C CA  . THR C 3 152 ? 160.168 249.233 334.269 1.00 44.82  ? 152 THR C CA  1 
ATOM 4748 C C   . THR C 3 152 ? 160.600 248.359 335.439 1.00 44.47  ? 152 THR C C   1 
ATOM 4749 O O   . THR C 3 152 ? 160.981 248.865 336.501 1.00 49.33  ? 152 THR C O   1 
ATOM 4750 C CB  . THR C 3 152 ? 161.343 250.018 333.690 1.00 46.29  ? 152 THR C CB  1 
ATOM 4751 O OG1 . THR C 3 152 ? 162.345 249.103 333.235 1.00 37.43  ? 152 THR C OG1 1 
ATOM 4752 C CG2 . THR C 3 152 ? 161.947 250.947 334.719 1.00 51.89  ? 152 THR C CG2 1 
ATOM 4753 N N   . HIS C 3 153 ? 160.513 247.046 335.249 1.00 45.12  ? 153 HIS C N   1 
ATOM 4754 C CA  . HIS C 3 153 ? 160.718 246.100 336.329 1.00 39.99  ? 153 HIS C CA  1 
ATOM 4755 C C   . HIS C 3 153 ? 161.149 244.769 335.742 1.00 42.06  ? 153 HIS C C   1 
ATOM 4756 O O   . HIS C 3 153 ? 161.019 244.525 334.541 1.00 43.43  ? 153 HIS C O   1 
ATOM 4757 C CB  . HIS C 3 153 ? 159.446 245.917 337.157 1.00 42.00  ? 153 HIS C CB  1 
ATOM 4758 C CG  . HIS C 3 153 ? 158.396 245.101 336.470 1.00 44.98  ? 153 HIS C CG  1 
ATOM 4759 N ND1 . HIS C 3 153 ? 157.958 245.375 335.194 1.00 50.78  ? 153 HIS C ND1 1 
ATOM 4760 C CD2 . HIS C 3 153 ? 157.698 244.018 336.883 1.00 47.44  ? 153 HIS C CD2 1 
ATOM 4761 C CE1 . HIS C 3 153 ? 157.035 244.496 334.849 1.00 45.76  ? 153 HIS C CE1 1 
ATOM 4762 N NE2 . HIS C 3 153 ? 156.859 243.661 335.856 1.00 46.93  ? 153 HIS C NE2 1 
ATOM 4763 N N   . VAL C 3 154 ? 161.671 243.912 336.609 1.00 48.42  ? 154 VAL C N   1 
ATOM 4764 C CA  . VAL C 3 154 ? 162.001 242.535 336.265 1.00 47.07  ? 154 VAL C CA  1 
ATOM 4765 C C   . VAL C 3 154 ? 161.532 241.633 337.394 1.00 45.93  ? 154 VAL C C   1 
ATOM 4766 O O   . VAL C 3 154 ? 161.648 241.982 338.574 1.00 51.82  ? 154 VAL C O   1 
ATOM 4767 C CB  . VAL C 3 154 ? 163.508 242.345 336.010 1.00 42.74  ? 154 VAL C CB  1 
ATOM 4768 C CG1 . VAL C 3 154 ? 163.940 243.152 334.807 1.00 48.10  ? 154 VAL C CG1 1 
ATOM 4769 C CG2 . VAL C 3 154 ? 164.308 242.732 337.237 1.00 42.23  ? 154 VAL C CG2 1 
ATOM 4770 N N   . ILE C 3 155 ? 160.989 240.478 337.031 1.00 39.42  ? 155 ILE C N   1 
ATOM 4771 C CA  . ILE C 3 155 ? 160.585 239.475 338.005 1.00 39.36  ? 155 ILE C CA  1 
ATOM 4772 C C   . ILE C 3 155 ? 161.735 238.494 338.176 1.00 47.13  ? 155 ILE C C   1 
ATOM 4773 O O   . ILE C 3 155 ? 162.110 237.784 337.239 1.00 52.76  ? 155 ILE C O   1 
ATOM 4774 C CB  . ILE C 3 155 ? 159.295 238.763 337.575 1.00 47.00  ? 155 ILE C CB  1 
ATOM 4775 C CG1 . ILE C 3 155 ? 158.141 239.765 337.568 1.00 44.09  ? 155 ILE C CG1 1 
ATOM 4776 C CG2 . ILE C 3 155 ? 158.985 237.606 338.510 1.00 48.27  ? 155 ILE C CG2 1 
ATOM 4777 C CD1 . ILE C 3 155 ? 156.821 239.191 337.146 1.00 46.72  ? 155 ILE C CD1 1 
ATOM 4778 N N   . TRP C 3 156 ? 162.293 238.467 339.377 1.00 44.77  ? 156 TRP C N   1 
ATOM 4779 C CA  . TRP C 3 156 ? 163.398 237.598 339.743 1.00 35.25  ? 156 TRP C CA  1 
ATOM 4780 C C   . TRP C 3 156 ? 162.820 236.373 340.437 1.00 46.33  ? 156 TRP C C   1 
ATOM 4781 O O   . TRP C 3 156 ? 162.108 236.504 341.437 1.00 48.81  ? 156 TRP C O   1 
ATOM 4782 C CB  . TRP C 3 156 ? 164.354 238.363 340.655 1.00 38.59  ? 156 TRP C CB  1 
ATOM 4783 C CG  . TRP C 3 156 ? 165.446 237.577 341.279 1.00 44.22  ? 156 TRP C CG  1 
ATOM 4784 C CD1 . TRP C 3 156 ? 165.977 236.407 340.840 1.00 45.75  ? 156 TRP C CD1 1 
ATOM 4785 C CD2 . TRP C 3 156 ? 166.151 237.918 342.472 1.00 44.33  ? 156 TRP C CD2 1 
ATOM 4786 N NE1 . TRP C 3 156 ? 166.971 235.994 341.688 1.00 43.80  ? 156 TRP C NE1 1 
ATOM 4787 C CE2 . TRP C 3 156 ? 167.097 236.907 342.699 1.00 48.43  ? 156 TRP C CE2 1 
ATOM 4788 C CE3 . TRP C 3 156 ? 166.073 238.983 343.371 1.00 33.67  ? 156 TRP C CE3 1 
ATOM 4789 C CZ2 . TRP C 3 156 ? 167.956 236.928 343.787 1.00 44.08  ? 156 TRP C CZ2 1 
ATOM 4790 C CZ3 . TRP C 3 156 ? 166.925 239.002 344.447 1.00 36.12  ? 156 TRP C CZ3 1 
ATOM 4791 C CH2 . TRP C 3 156 ? 167.853 237.982 344.648 1.00 47.17  ? 156 TRP C CH2 1 
ATOM 4792 N N   . ASP C 3 157 ? 163.105 235.191 339.901 1.00 51.75  ? 157 ASP C N   1 
ATOM 4793 C CA  . ASP C 3 157 ? 162.527 233.949 340.406 1.00 42.63  ? 157 ASP C CA  1 
ATOM 4794 C C   . ASP C 3 157 ? 163.538 233.275 341.324 1.00 48.69  ? 157 ASP C C   1 
ATOM 4795 O O   . ASP C 3 157 ? 164.518 232.689 340.864 1.00 53.96  ? 157 ASP C O   1 
ATOM 4796 C CB  . ASP C 3 157 ? 162.129 233.031 339.258 1.00 45.25  ? 157 ASP C CB  1 
ATOM 4797 C CG  . ASP C 3 157 ? 161.288 231.860 339.720 1.00 56.59  ? 157 ASP C CG  1 
ATOM 4798 O OD1 . ASP C 3 157 ? 160.993 231.779 340.929 1.00 61.78  ? 157 ASP C OD1 1 
ATOM 4799 O OD2 . ASP C 3 157 ? 160.919 231.021 338.874 1.00 56.24  ? 157 ASP C OD2 1 
ATOM 4800 N N   . ILE C 3 158 ? 163.289 233.355 342.628 1.00 46.29  ? 158 ILE C N   1 
ATOM 4801 C CA  . ILE C 3 158 ? 164.092 232.636 343.610 1.00 42.13  ? 158 ILE C CA  1 
ATOM 4802 C C   . ILE C 3 158 ? 163.726 231.161 343.502 1.00 53.55  ? 158 ILE C C   1 
ATOM 4803 O O   . ILE C 3 158 ? 162.619 230.760 343.874 1.00 60.51  ? 158 ILE C O   1 
ATOM 4804 C CB  . ILE C 3 158 ? 163.845 233.163 345.026 1.00 41.90  ? 158 ILE C CB  1 
ATOM 4805 C CG1 . ILE C 3 158 ? 164.631 234.449 345.261 1.00 47.43  ? 158 ILE C CG1 1 
ATOM 4806 C CG2 . ILE C 3 158 ? 164.197 232.112 346.054 1.00 49.29  ? 158 ILE C CG2 1 
ATOM 4807 C CD1 . ILE C 3 158 ? 164.160 235.607 344.441 1.00 48.38  ? 158 ILE C CD1 1 
ATOM 4808 N N   . GLY C 3 159 ? 164.649 230.351 343.001 1.00 48.89  ? 159 GLY C N   1 
ATOM 4809 C CA  . GLY C 3 159 ? 164.361 228.955 342.757 1.00 49.89  ? 159 GLY C CA  1 
ATOM 4810 C C   . GLY C 3 159 ? 165.050 228.439 341.514 1.00 55.04  ? 159 GLY C C   1 
ATOM 4811 O O   . GLY C 3 159 ? 165.313 227.240 341.396 1.00 61.37  ? 159 GLY C O   1 
ATOM 4812 N N   . LEU C 3 160 ? 165.346 229.333 340.578 1.00 54.20  ? 160 LEU C N   1 
ATOM 4813 C CA  . LEU C 3 160 ? 166.123 228.963 339.406 1.00 55.91  ? 160 LEU C CA  1 
ATOM 4814 C C   . LEU C 3 160 ? 167.209 229.975 339.074 1.00 54.29  ? 160 LEU C C   1 
ATOM 4815 O O   . LEU C 3 160 ? 168.003 229.721 338.165 1.00 57.81  ? 160 LEU C O   1 
ATOM 4816 C CB  . LEU C 3 160 ? 165.205 228.774 338.191 1.00 55.01  ? 160 LEU C CB  1 
ATOM 4817 C CG  . LEU C 3 160 ? 164.596 230.033 337.582 1.00 57.50  ? 160 LEU C CG  1 
ATOM 4818 C CD1 . LEU C 3 160 ? 165.312 230.389 336.293 1.00 56.19  ? 160 LEU C CD1 1 
ATOM 4819 C CD2 . LEU C 3 160 ? 163.114 229.836 337.335 1.00 52.23  ? 160 LEU C CD2 1 
ATOM 4820 N N   . GLN C 3 161 ? 167.266 231.106 339.770 1.00 51.36  ? 161 GLN C N   1 
ATOM 4821 C CA  . GLN C 3 161 ? 168.346 232.069 339.631 1.00 51.35  ? 161 GLN C CA  1 
ATOM 4822 C C   . GLN C 3 161 ? 168.669 232.620 341.008 1.00 52.65  ? 161 GLN C C   1 
ATOM 4823 O O   . GLN C 3 161 ? 167.764 232.976 341.766 1.00 59.18  ? 161 GLN C O   1 
ATOM 4824 C CB  . GLN C 3 161 ? 167.970 233.209 338.684 1.00 55.03  ? 161 GLN C CB  1 
ATOM 4825 C CG  . GLN C 3 161 ? 167.943 232.815 337.226 1.00 60.27  ? 161 GLN C CG  1 
ATOM 4826 C CD  . GLN C 3 161 ? 169.318 232.462 336.698 1.00 62.02  ? 161 GLN C CD  1 
ATOM 4827 O OE1 . GLN C 3 161 ? 170.324 232.664 337.378 1.00 59.17  ? 161 GLN C OE1 1 
ATOM 4828 N NE2 . GLN C 3 161 ? 169.371 231.934 335.482 1.00 60.17  ? 161 GLN C NE2 1 
ATOM 4829 N N   . SER C 3 162 ? 169.958 232.689 341.328 1.00 43.55  ? 162 SER C N   1 
ATOM 4830 C CA  . SER C 3 162 ? 170.388 233.135 342.643 1.00 39.10  ? 162 SER C CA  1 
ATOM 4831 C C   . SER C 3 162 ? 170.775 234.604 342.689 1.00 45.51  ? 162 SER C C   1 
ATOM 4832 O O   . SER C 3 162 ? 170.815 235.179 343.781 1.00 47.80  ? 162 SER C O   1 
ATOM 4833 C CB  . SER C 3 162 ? 171.573 232.294 343.119 1.00 47.21  ? 162 SER C CB  1 
ATOM 4834 O OG  . SER C 3 162 ? 171.213 230.929 343.212 1.00 50.74  ? 162 SER C OG  1 
ATOM 4835 N N   . SER C 3 163 ? 171.056 235.222 341.545 1.00 48.97  ? 163 SER C N   1 
ATOM 4836 C CA  . SER C 3 163 ? 171.472 236.615 341.502 1.00 41.03  ? 163 SER C CA  1 
ATOM 4837 C C   . SER C 3 163 ? 170.731 237.339 340.390 1.00 38.74  ? 163 SER C C   1 
ATOM 4838 O O   . SER C 3 163 ? 170.500 236.776 339.318 1.00 43.12  ? 163 SER C O   1 
ATOM 4839 C CB  . SER C 3 163 ? 172.983 236.733 341.289 1.00 44.13  ? 163 SER C CB  1 
ATOM 4840 O OG  . SER C 3 163 ? 173.371 236.121 340.074 1.00 51.52  ? 163 SER C OG  1 
ATOM 4841 N N   . CYS C 3 164 ? 170.375 238.595 340.650 1.00 45.95  ? 164 CYS C N   1 
ATOM 4842 C CA  . CYS C 3 164 ? 169.652 239.430 339.698 1.00 41.97  ? 164 CYS C CA  1 
ATOM 4843 C C   . CYS C 3 164 ? 170.422 240.720 339.466 1.00 41.37  ? 164 CYS C C   1 
ATOM 4844 O O   . CYS C 3 164 ? 170.828 241.380 340.426 1.00 53.22  ? 164 CYS C O   1 
ATOM 4845 C CB  . CYS C 3 164 ? 168.245 239.750 340.205 1.00 41.71  ? 164 CYS C CB  1 
ATOM 4846 S SG  . CYS C 3 164 ? 167.216 240.640 339.024 1.00 50.70  ? 164 CYS C SG  1 
ATOM 4847 N N   . THR C 3 165 ? 170.599 241.088 338.200 1.00 38.02  ? 165 THR C N   1 
ATOM 4848 C CA  . THR C 3 165 ? 171.349 242.276 337.814 1.00 41.32  ? 165 THR C CA  1 
ATOM 4849 C C   . THR C 3 165 ? 170.418 243.307 337.189 1.00 43.75  ? 165 THR C C   1 
ATOM 4850 O O   . THR C 3 165 ? 169.473 242.954 336.479 1.00 50.47  ? 165 THR C O   1 
ATOM 4851 C CB  . THR C 3 165 ? 172.461 241.925 336.824 1.00 44.79  ? 165 THR C CB  1 
ATOM 4852 O OG1 . THR C 3 165 ? 173.283 240.889 337.370 1.00 57.48  ? 165 THR C OG1 1 
ATOM 4853 C CG2 . THR C 3 165 ? 173.324 243.135 336.537 1.00 43.90  ? 165 THR C CG2 1 
ATOM 4854 N N   . MET C 3 166 ? 170.691 244.582 337.457 1.00 42.25  ? 166 MET C N   1 
ATOM 4855 C CA  . MET C 3 166 ? 169.875 245.685 336.960 1.00 40.08  ? 166 MET C CA  1 
ATOM 4856 C C   . MET C 3 166 ? 170.796 246.845 336.625 1.00 41.88  ? 166 MET C C   1 
ATOM 4857 O O   . MET C 3 166 ? 171.527 247.324 337.495 1.00 48.02  ? 166 MET C O   1 
ATOM 4858 C CB  . MET C 3 166 ? 168.833 246.098 338.006 1.00 47.12  ? 166 MET C CB  1 
ATOM 4859 C CG  . MET C 3 166 ? 168.033 247.355 337.676 1.00 49.95  ? 166 MET C CG  1 
ATOM 4860 S SD  . MET C 3 166 ? 166.881 247.163 336.302 1.00 67.56  ? 166 MET C SD  1 
ATOM 4861 C CE  . MET C 3 166 ? 165.545 246.264 337.082 1.00 44.28  ? 166 MET C CE  1 
ATOM 4862 N N   . VAL C 3 167 ? 170.762 247.302 335.376 1.00 41.53  ? 167 VAL C N   1 
ATOM 4863 C CA  . VAL C 3 167 ? 171.629 248.378 334.906 1.00 39.23  ? 167 VAL C CA  1 
ATOM 4864 C C   . VAL C 3 167 ? 170.811 249.656 334.808 1.00 38.57  ? 167 VAL C C   1 
ATOM 4865 O O   . VAL C 3 167 ? 169.800 249.704 334.100 1.00 50.94  ? 167 VAL C O   1 
ATOM 4866 C CB  . VAL C 3 167 ? 172.266 248.036 333.551 1.00 36.13  ? 167 VAL C CB  1 
ATOM 4867 C CG1 . VAL C 3 167 ? 172.953 249.252 332.975 1.00 37.39  ? 167 VAL C CG1 1 
ATOM 4868 C CG2 . VAL C 3 167 ? 173.250 246.899 333.702 1.00 40.19  ? 167 VAL C CG2 1 
ATOM 4869 N N   . VAL C 3 168 ? 171.253 250.691 335.512 1.00 31.83  ? 168 VAL C N   1 
ATOM 4870 C CA  . VAL C 3 168 ? 170.606 251.998 335.486 1.00 32.33  ? 168 VAL C CA  1 
ATOM 4871 C C   . VAL C 3 168 ? 171.331 252.856 334.453 1.00 37.21  ? 168 VAL C C   1 
ATOM 4872 O O   . VAL C 3 168 ? 172.548 253.071 334.592 1.00 45.34  ? 168 VAL C O   1 
ATOM 4873 C CB  . VAL C 3 168 ? 170.640 252.660 336.865 1.00 31.47  ? 168 VAL C CB  1 
ATOM 4874 C CG1 . VAL C 3 168 ? 170.293 254.126 336.752 1.00 34.63  ? 168 VAL C CG1 1 
ATOM 4875 C CG2 . VAL C 3 168 ? 169.687 251.952 337.804 1.00 34.66  ? 168 VAL C CG2 1 
ATOM 4876 N N   . PRO C 3 169 ? 170.649 253.358 333.428 1.00 41.05  ? 169 PRO C N   1 
ATOM 4877 C CA  . PRO C 3 169 ? 171.323 254.110 332.368 1.00 40.95  ? 169 PRO C CA  1 
ATOM 4878 C C   . PRO C 3 169 ? 171.558 255.560 332.779 1.00 50.58  ? 169 PRO C C   1 
ATOM 4879 O O   . PRO C 3 169 ? 171.246 255.980 333.890 1.00 50.60  ? 169 PRO C O   1 
ATOM 4880 C CB  . PRO C 3 169 ? 170.341 254.004 331.206 1.00 37.14  ? 169 PRO C CB  1 
ATOM 4881 C CG  . PRO C 3 169 ? 169.024 253.984 331.868 1.00 40.62  ? 169 PRO C CG  1 
ATOM 4882 C CD  . PRO C 3 169 ? 169.206 253.235 333.159 1.00 43.45  ? 169 PRO C CD  1 
ATOM 4883 N N   . TRP C 3 170 ? 172.113 256.327 331.846 1.00 49.88  ? 170 TRP C N   1 
ATOM 4884 C CA  . TRP C 3 170 ? 172.495 257.712 332.083 1.00 39.89  ? 170 TRP C CA  1 
ATOM 4885 C C   . TRP C 3 170 ? 171.451 258.635 331.469 1.00 45.84  ? 170 TRP C C   1 
ATOM 4886 O O   . TRP C 3 170 ? 171.260 258.637 330.249 1.00 47.43  ? 170 TRP C O   1 
ATOM 4887 C CB  . TRP C 3 170 ? 173.878 257.989 331.496 1.00 37.18  ? 170 TRP C CB  1 
ATOM 4888 C CG  . TRP C 3 170 ? 174.329 259.404 331.620 1.00 41.09  ? 170 TRP C CG  1 
ATOM 4889 C CD1 . TRP C 3 170 ? 174.831 260.189 330.631 1.00 40.50  ? 170 TRP C CD1 1 
ATOM 4890 C CD2 . TRP C 3 170 ? 174.321 260.206 332.804 1.00 41.21  ? 170 TRP C CD2 1 
ATOM 4891 N NE1 . TRP C 3 170 ? 175.134 261.430 331.122 1.00 40.48  ? 170 TRP C NE1 1 
ATOM 4892 C CE2 . TRP C 3 170 ? 174.832 261.464 332.456 1.00 40.24  ? 170 TRP C CE2 1 
ATOM 4893 C CE3 . TRP C 3 170 ? 173.931 259.980 334.124 1.00 39.96  ? 170 TRP C CE3 1 
ATOM 4894 C CZ2 . TRP C 3 170 ? 174.961 262.491 333.377 1.00 41.78  ? 170 TRP C CZ2 1 
ATOM 4895 C CZ3 . TRP C 3 170 ? 174.062 261.000 335.033 1.00 37.80  ? 170 TRP C CZ3 1 
ATOM 4896 C CH2 . TRP C 3 170 ? 174.574 262.239 334.657 1.00 38.78  ? 170 TRP C CH2 1 
ATOM 4897 N N   . ILE C 3 171 ? 170.781 259.414 332.315 1.00 50.99  ? 171 ILE C N   1 
ATOM 4898 C CA  . ILE C 3 171 ? 169.785 260.387 331.886 1.00 45.34  ? 171 ILE C CA  1 
ATOM 4899 C C   . ILE C 3 171 ? 170.093 261.714 332.564 1.00 45.77  ? 171 ILE C C   1 
ATOM 4900 O O   . ILE C 3 171 ? 170.172 261.781 333.796 1.00 48.02  ? 171 ILE C O   1 
ATOM 4901 C CB  . ILE C 3 171 ? 168.356 259.926 332.218 1.00 42.37  ? 171 ILE C CB  1 
ATOM 4902 C CG1 . ILE C 3 171 ? 167.896 258.878 331.202 1.00 47.30  ? 171 ILE C CG1 1 
ATOM 4903 C CG2 . ILE C 3 171 ? 167.399 261.111 332.251 1.00 46.29  ? 171 ILE C CG2 1 
ATOM 4904 C CD1 . ILE C 3 171 ? 166.593 258.197 331.560 1.00 51.00  ? 171 ILE C CD1 1 
ATOM 4905 N N   . SER C 3 172 ? 170.264 262.765 331.768 1.00 46.21  ? 172 SER C N   1 
ATOM 4906 C CA  . SER C 3 172 ? 170.424 264.111 332.301 1.00 49.27  ? 172 SER C CA  1 
ATOM 4907 C C   . SER C 3 172 ? 170.359 265.099 331.149 1.00 52.32  ? 172 SER C C   1 
ATOM 4908 O O   . SER C 3 172 ? 170.743 264.778 330.021 1.00 49.00  ? 172 SER C O   1 
ATOM 4909 C CB  . SER C 3 172 ? 171.748 264.272 333.061 1.00 50.74  ? 172 SER C CB  1 
ATOM 4910 O OG  . SER C 3 172 ? 172.849 264.339 332.172 1.00 51.22  ? 172 SER C OG  1 
ATOM 4911 N N   . ASN C 3 173 ? 169.856 266.300 331.443 1.00 52.60  ? 173 ASN C N   1 
ATOM 4912 C CA  . ASN C 3 173 ? 169.870 267.362 330.443 1.00 46.05  ? 173 ASN C CA  1 
ATOM 4913 C C   . ASN C 3 173 ? 171.296 267.774 330.102 1.00 50.79  ? 173 ASN C C   1 
ATOM 4914 O O   . ASN C 3 173 ? 171.624 267.990 328.929 1.00 53.88  ? 173 ASN C O   1 
ATOM 4915 C CB  . ASN C 3 173 ? 169.065 268.566 330.932 1.00 40.82  ? 173 ASN C CB  1 
ATOM 4916 C CG  . ASN C 3 173 ? 169.350 268.913 332.372 1.00 44.81  ? 173 ASN C CG  1 
ATOM 4917 O OD1 . ASN C 3 173 ? 169.551 268.032 333.203 1.00 54.51  ? 173 ASN C OD1 1 
ATOM 4918 N ND2 . ASN C 3 173 ? 169.364 270.199 332.681 1.00 45.56  ? 173 ASN C ND2 1 
ATOM 4919 N N   . THR C 3 174 ? 172.158 267.873 331.106 1.00 44.87  ? 174 THR C N   1 
ATOM 4920 C CA  . THR C 3 174 ? 173.552 268.238 330.910 1.00 40.79  ? 174 THR C CA  1 
ATOM 4921 C C   . THR C 3 174 ? 174.398 266.996 330.647 1.00 38.70  ? 174 THR C C   1 
ATOM 4922 O O   . THR C 3 174 ? 173.970 265.863 330.874 1.00 51.97  ? 174 THR C O   1 
ATOM 4923 C CB  . THR C 3 174 ? 174.083 268.981 332.133 1.00 41.34  ? 174 THR C CB  1 
ATOM 4924 O OG1 . THR C 3 174 ? 173.849 268.199 333.308 1.00 40.70  ? 174 THR C OG1 1 
ATOM 4925 C CG2 . THR C 3 174 ? 173.398 270.318 332.289 1.00 38.10  ? 174 THR C CG2 1 
ATOM 4926 N N   . THR C 3 175 ? 175.617 267.223 330.153 1.00 34.03  ? 175 THR C N   1 
ATOM 4927 C CA  . THR C 3 175 ? 176.544 266.118 329.935 1.00 42.14  ? 175 THR C CA  1 
ATOM 4928 C C   . THR C 3 175 ? 177.152 265.609 331.234 1.00 43.60  ? 175 THR C C   1 
ATOM 4929 O O   . THR C 3 175 ? 177.638 264.475 331.274 1.00 39.22  ? 175 THR C O   1 
ATOM 4930 C CB  . THR C 3 175 ? 177.667 266.539 328.990 1.00 44.37  ? 175 THR C CB  1 
ATOM 4931 O OG1 . THR C 3 175 ? 178.301 267.719 329.495 1.00 45.40  ? 175 THR C OG1 1 
ATOM 4932 C CG2 . THR C 3 175 ? 177.125 266.813 327.604 1.00 47.32  ? 175 THR C CG2 1 
ATOM 4933 N N   . TYR C 3 176 ? 177.144 266.421 332.286 1.00 36.47  ? 176 TYR C N   1 
ATOM 4934 C CA  . TYR C 3 176 ? 177.688 266.040 333.577 1.00 23.30  ? 176 TYR C CA  1 
ATOM 4935 C C   . TYR C 3 176 ? 176.714 266.466 334.658 1.00 28.16  ? 176 TYR C C   1 
ATOM 4936 O O   . TYR C 3 176 ? 175.870 267.338 334.451 1.00 41.67  ? 176 TYR C O   1 
ATOM 4937 C CB  . TYR C 3 176 ? 179.057 266.677 333.835 1.00 35.30  ? 176 TYR C CB  1 
ATOM 4938 C CG  . TYR C 3 176 ? 180.214 265.936 333.217 1.00 37.57  ? 176 TYR C CG  1 
ATOM 4939 C CD1 . TYR C 3 176 ? 180.597 266.177 331.913 1.00 43.14  ? 176 TYR C CD1 1 
ATOM 4940 C CD2 . TYR C 3 176 ? 180.928 265.004 333.943 1.00 34.38  ? 176 TYR C CD2 1 
ATOM 4941 C CE1 . TYR C 3 176 ? 181.652 265.502 331.348 1.00 42.49  ? 176 TYR C CE1 1 
ATOM 4942 C CE2 . TYR C 3 176 ? 181.981 264.325 333.386 1.00 39.28  ? 176 TYR C CE2 1 
ATOM 4943 C CZ  . TYR C 3 176 ? 182.341 264.578 332.090 1.00 36.76  ? 176 TYR C CZ  1 
ATOM 4944 O OH  . TYR C 3 176 ? 183.397 263.902 331.531 1.00 37.64  ? 176 TYR C OH  1 
ATOM 4945 N N   . ARG C 3 177 ? 176.838 265.834 335.817 1.00 35.67  ? 177 ARG C N   1 
ATOM 4946 C CA  . ARG C 3 177 ? 176.005 266.136 336.967 1.00 34.40  ? 177 ARG C CA  1 
ATOM 4947 C C   . ARG C 3 177 ? 176.895 266.282 338.189 1.00 37.08  ? 177 ARG C C   1 
ATOM 4948 O O   . ARG C 3 177 ? 177.952 265.657 338.279 1.00 45.21  ? 177 ARG C O   1 
ATOM 4949 C CB  . ARG C 3 177 ? 174.959 265.041 337.189 1.00 35.66  ? 177 ARG C CB  1 
ATOM 4950 C CG  . ARG C 3 177 ? 173.956 265.349 338.279 1.00 39.50  ? 177 ARG C CG  1 
ATOM 4951 C CD  . ARG C 3 177 ? 172.950 264.226 338.425 1.00 46.65  ? 177 ARG C CD  1 
ATOM 4952 N NE  . ARG C 3 177 ? 172.114 264.073 337.241 1.00 47.45  ? 177 ARG C NE  1 
ATOM 4953 C CZ  . ARG C 3 177 ? 171.389 262.996 336.970 1.00 45.56  ? 177 ARG C CZ  1 
ATOM 4954 N NH1 . ARG C 3 177 ? 171.398 261.939 337.763 1.00 42.84  ? 177 ARG C NH1 1 
ATOM 4955 N NH2 . ARG C 3 177 ? 170.640 262.977 335.872 1.00 47.39  ? 177 ARG C NH2 1 
ATOM 4956 N N   . LEU C 3 178 ? 176.469 267.121 339.126 1.00 33.73  ? 178 LEU C N   1 
ATOM 4957 C CA  . LEU C 3 178 ? 177.262 267.378 340.318 1.00 32.13  ? 178 LEU C CA  1 
ATOM 4958 C C   . LEU C 3 178 ? 177.173 266.203 341.279 1.00 40.40  ? 178 LEU C C   1 
ATOM 4959 O O   . LEU C 3 178 ? 176.085 265.683 341.535 1.00 45.65  ? 178 LEU C O   1 
ATOM 4960 C CB  . LEU C 3 178 ? 176.787 268.649 341.014 1.00 39.57  ? 178 LEU C CB  1 
ATOM 4961 C CG  . LEU C 3 178 ? 176.718 269.915 340.166 1.00 45.28  ? 178 LEU C CG  1 
ATOM 4962 C CD1 . LEU C 3 178 ? 176.328 271.089 341.044 1.00 39.46  ? 178 LEU C CD1 1 
ATOM 4963 C CD2 . LEU C 3 178 ? 178.032 270.173 339.457 1.00 40.18  ? 178 LEU C CD2 1 
ATOM 4964 N N   . THR C 3 179 ? 178.321 265.791 341.820 1.00 49.16  ? 179 THR C N   1 
ATOM 4965 C CA  . THR C 3 179 ? 178.327 264.723 342.814 1.00 43.14  ? 179 THR C CA  1 
ATOM 4966 C C   . THR C 3 179 ? 177.549 265.135 344.054 1.00 44.10  ? 179 THR C C   1 
ATOM 4967 O O   . THR C 3 179 ? 176.651 264.417 344.506 1.00 52.43  ? 179 THR C O   1 
ATOM 4968 C CB  . THR C 3 179 ? 179.761 264.359 343.193 1.00 33.30  ? 179 THR C CB  1 
ATOM 4969 O OG1 . THR C 3 179 ? 180.420 265.514 343.719 1.00 37.80  ? 179 THR C OG1 1 
ATOM 4970 C CG2 . THR C 3 179 ? 180.524 263.841 341.991 1.00 33.12  ? 179 THR C CG2 1 
ATOM 4971 N N   . ILE C 3 180 ? 177.875 266.293 344.615 1.00 46.53  ? 180 ILE C N   1 
ATOM 4972 C CA  . ILE C 3 180 ? 177.210 266.815 345.801 1.00 52.67  ? 180 ILE C CA  1 
ATOM 4973 C C   . ILE C 3 180 ? 176.289 267.937 345.352 1.00 57.76  ? 180 ILE C C   1 
ATOM 4974 O O   . ILE C 3 180 ? 176.744 268.953 344.814 1.00 55.96  ? 180 ILE C O   1 
ATOM 4975 C CB  . ILE C 3 180 ? 178.211 267.308 346.853 1.00 49.76  ? 180 ILE C CB  1 
ATOM 4976 C CG1 . ILE C 3 180 ? 178.912 266.117 347.508 1.00 49.83  ? 180 ILE C CG1 1 
ATOM 4977 C CG2 . ILE C 3 180 ? 177.499 268.165 347.891 1.00 50.08  ? 180 ILE C CG2 1 
ATOM 4978 C CD1 . ILE C 3 180 ? 180.022 266.502 348.466 1.00 53.99  ? 180 ILE C CD1 1 
ATOM 4979 N N   . ASP C 3 181 ? 174.993 267.754 345.578 1.00 75.46  ? 181 ASP C N   1 
ATOM 4980 C CA  . ASP C 3 181 ? 173.994 268.748 345.224 1.00 76.22  ? 181 ASP C CA  1 
ATOM 4981 C C   . ASP C 3 181 ? 172.867 268.672 346.240 1.00 77.47  ? 181 ASP C C   1 
ATOM 4982 O O   . ASP C 3 181 ? 172.708 267.673 346.945 1.00 80.66  ? 181 ASP C O   1 
ATOM 4983 C CB  . ASP C 3 181 ? 173.463 268.528 343.804 1.00 72.77  ? 181 ASP C CB  1 
ATOM 4984 C CG  . ASP C 3 181 ? 173.117 267.077 343.531 1.00 77.13  ? 181 ASP C CG  1 
ATOM 4985 O OD1 . ASP C 3 181 ? 173.169 266.263 344.477 1.00 76.85  ? 181 ASP C OD1 1 
ATOM 4986 O OD2 . ASP C 3 181 ? 172.800 266.749 342.369 1.00 76.73  ? 181 ASP C OD2 1 
ATOM 4987 N N   . ASP C 3 182 ? 172.095 269.749 346.322 1.00 92.14  ? 182 ASP C N   1 
ATOM 4988 C CA  . ASP C 3 182 ? 170.967 269.820 347.236 1.00 96.40  ? 182 ASP C CA  1 
ATOM 4989 C C   . ASP C 3 182 ? 169.748 270.337 346.491 1.00 98.69  ? 182 ASP C C   1 
ATOM 4990 O O   . ASP C 3 182 ? 169.862 271.130 345.554 1.00 100.09 ? 182 ASP C O   1 
ATOM 4991 C CB  . ASP C 3 182 ? 171.271 270.721 348.436 1.00 97.69  ? 182 ASP C CB  1 
ATOM 4992 C CG  . ASP C 3 182 ? 170.288 270.528 349.569 1.00 98.24  ? 182 ASP C CG  1 
ATOM 4993 O OD1 . ASP C 3 182 ? 169.148 270.097 349.300 1.00 98.55  ? 182 ASP C OD1 1 
ATOM 4994 O OD2 . ASP C 3 182 ? 170.655 270.805 350.729 1.00 98.06  ? 182 ASP C OD2 1 
ATOM 4995 N N   . SER C 3 183 ? 168.577 269.878 346.921 1.00 98.93  ? 183 SER C N   1 
ATOM 4996 C CA  . SER C 3 183 ? 167.281 270.174 346.326 1.00 98.73  ? 183 SER C CA  1 
ATOM 4997 C C   . SER C 3 183 ? 167.031 269.323 345.090 1.00 97.46  ? 183 SER C C   1 
ATOM 4998 O O   . SER C 3 183 ? 165.957 269.446 344.488 1.00 97.90  ? 183 SER C O   1 
ATOM 4999 C CB  . SER C 3 183 ? 167.128 271.650 345.934 1.00 97.05  ? 183 SER C CB  1 
ATOM 5000 O OG  . SER C 3 183 ? 167.981 271.970 344.849 1.00 96.47  ? 183 SER C OG  1 
ATOM 5001 N N   . PHE C 3 184 ? 167.974 268.473 344.682 1.00 80.34  ? 184 PHE C N   1 
ATOM 5002 C CA  . PHE C 3 184 ? 167.753 267.635 343.509 1.00 79.25  ? 184 PHE C CA  1 
ATOM 5003 C C   . PHE C 3 184 ? 166.625 266.642 343.762 1.00 78.80  ? 184 PHE C C   1 
ATOM 5004 O O   . PHE C 3 184 ? 165.599 266.660 343.073 1.00 79.24  ? 184 PHE C O   1 
ATOM 5005 C CB  . PHE C 3 184 ? 169.048 266.913 343.133 1.00 75.29  ? 184 PHE C CB  1 
ATOM 5006 C CG  . PHE C 3 184 ? 168.953 266.131 341.857 1.00 78.03  ? 184 PHE C CG  1 
ATOM 5007 C CD1 . PHE C 3 184 ? 168.562 266.746 340.683 1.00 77.04  ? 184 PHE C CD1 1 
ATOM 5008 C CD2 . PHE C 3 184 ? 169.262 264.782 341.830 1.00 76.62  ? 184 PHE C CD2 1 
ATOM 5009 C CE1 . PHE C 3 184 ? 168.472 266.031 339.508 1.00 78.27  ? 184 PHE C CE1 1 
ATOM 5010 C CE2 . PHE C 3 184 ? 169.176 264.063 340.656 1.00 74.16  ? 184 PHE C CE2 1 
ATOM 5011 C CZ  . PHE C 3 184 ? 168.780 264.687 339.494 1.00 76.39  ? 184 PHE C CZ  1 
ATOM 5012 N N   . THR C 3 185 ? 166.790 265.779 344.763 1.00 79.22  ? 185 THR C N   1 
ATOM 5013 C CA  . THR C 3 185 ? 165.740 264.847 345.176 1.00 80.99  ? 185 THR C CA  1 
ATOM 5014 C C   . THR C 3 185 ? 165.207 264.065 343.979 1.00 80.01  ? 185 THR C C   1 
ATOM 5015 O O   . THR C 3 185 ? 164.000 263.881 343.809 1.00 77.83  ? 185 THR C O   1 
ATOM 5016 C CB  . THR C 3 185 ? 164.610 265.584 345.893 1.00 84.06  ? 185 THR C CB  1 
ATOM 5017 O OG1 . THR C 3 185 ? 165.167 266.510 346.833 1.00 83.65  ? 185 THR C OG1 1 
ATOM 5018 C CG2 . THR C 3 185 ? 163.718 264.603 346.635 1.00 81.13  ? 185 THR C CG2 1 
ATOM 5019 N N   . GLU C 3 186 ? 166.124 263.602 343.141 1.00 71.07  ? 186 GLU C N   1 
ATOM 5020 C CA  . GLU C 3 186 ? 165.786 262.871 341.930 1.00 70.32  ? 186 GLU C CA  1 
ATOM 5021 C C   . GLU C 3 186 ? 166.906 261.866 341.684 1.00 73.35  ? 186 GLU C C   1 
ATOM 5022 O O   . GLU C 3 186 ? 167.593 261.446 342.620 1.00 74.85  ? 186 GLU C O   1 
ATOM 5023 C CB  . GLU C 3 186 ? 165.559 263.846 340.760 1.00 70.62  ? 186 GLU C CB  1 
ATOM 5024 C CG  . GLU C 3 186 ? 164.303 264.691 340.889 1.00 72.99  ? 186 GLU C CG  1 
ATOM 5025 C CD  . GLU C 3 186 ? 164.208 265.757 339.818 1.00 74.48  ? 186 GLU C CD  1 
ATOM 5026 O OE1 . GLU C 3 186 ? 164.861 265.603 338.766 1.00 74.04  ? 186 GLU C OE1 1 
ATOM 5027 O OE2 . GLU C 3 186 ? 163.487 266.754 340.033 1.00 74.89  ? 186 GLU C OE2 1 
ATOM 5028 N N   . GLY C 3 187 ? 167.077 261.459 340.431 1.00 63.38  ? 187 GLY C N   1 
ATOM 5029 C CA  . GLY C 3 187 ? 168.017 260.424 340.075 1.00 56.84  ? 187 GLY C CA  1 
ATOM 5030 C C   . GLY C 3 187 ? 167.390 259.057 339.970 1.00 55.06  ? 187 GLY C C   1 
ATOM 5031 O O   . GLY C 3 187 ? 168.010 258.148 339.408 1.00 57.25  ? 187 GLY C O   1 
ATOM 5032 N N   . GLY C 3 188 ? 166.174 258.896 340.472 1.00 49.73  ? 188 GLY C N   1 
ATOM 5033 C CA  . GLY C 3 188 ? 165.468 257.636 340.409 1.00 54.03  ? 188 GLY C CA  1 
ATOM 5034 C C   . GLY C 3 188 ? 165.627 256.837 341.683 1.00 52.86  ? 188 GLY C C   1 
ATOM 5035 O O   . GLY C 3 188 ? 166.255 257.258 342.657 1.00 49.98  ? 188 GLY C O   1 
ATOM 5036 N N   . TYR C 3 189 ? 165.017 255.657 341.668 1.00 50.69  ? 189 TYR C N   1 
ATOM 5037 C CA  . TYR C 3 189 ? 165.096 254.738 342.790 1.00 43.73  ? 189 TYR C CA  1 
ATOM 5038 C C   . TYR C 3 189 ? 165.133 253.317 342.260 1.00 48.68  ? 189 TYR C C   1 
ATOM 5039 O O   . TYR C 3 189 ? 164.707 253.043 341.138 1.00 53.75  ? 189 TYR C O   1 
ATOM 5040 C CB  . TYR C 3 189 ? 163.905 254.887 343.742 1.00 42.33  ? 189 TYR C CB  1 
ATOM 5041 C CG  . TYR C 3 189 ? 163.730 256.263 344.323 1.00 45.70  ? 189 TYR C CG  1 
ATOM 5042 C CD1 . TYR C 3 189 ? 163.121 257.269 343.595 1.00 50.79  ? 189 TYR C CD1 1 
ATOM 5043 C CD2 . TYR C 3 189 ? 164.151 256.553 345.608 1.00 49.02  ? 189 TYR C CD2 1 
ATOM 5044 C CE1 . TYR C 3 189 ? 162.950 258.527 344.123 1.00 51.63  ? 189 TYR C CE1 1 
ATOM 5045 C CE2 . TYR C 3 189 ? 163.983 257.808 346.145 1.00 51.19  ? 189 TYR C CE2 1 
ATOM 5046 C CZ  . TYR C 3 189 ? 163.380 258.791 345.397 1.00 51.52  ? 189 TYR C CZ  1 
ATOM 5047 O OH  . TYR C 3 189 ? 163.206 260.048 345.923 1.00 52.03  ? 189 TYR C OH  1 
ATOM 5048 N N   . ILE C 3 190 ? 165.651 252.413 343.085 1.00 46.20  ? 190 ILE C N   1 
ATOM 5049 C CA  . ILE C 3 190 ? 165.534 250.979 342.856 1.00 37.96  ? 190 ILE C CA  1 
ATOM 5050 C C   . ILE C 3 190 ? 164.802 250.385 344.047 1.00 43.47  ? 190 ILE C C   1 
ATOM 5051 O O   . ILE C 3 190 ? 165.201 250.604 345.195 1.00 42.90  ? 190 ILE C O   1 
ATOM 5052 C CB  . ILE C 3 190 ? 166.904 250.305 342.658 1.00 33.94  ? 190 ILE C CB  1 
ATOM 5053 C CG1 . ILE C 3 190 ? 167.541 250.750 341.345 1.00 42.85  ? 190 ILE C CG1 1 
ATOM 5054 C CG2 . ILE C 3 190 ? 166.756 248.803 342.642 1.00 47.75  ? 190 ILE C CG2 1 
ATOM 5055 C CD1 . ILE C 3 190 ? 168.163 252.121 341.400 1.00 50.92  ? 190 ILE C CD1 1 
ATOM 5056 N N   . SER C 3 191 ? 163.732 249.642 343.778 1.00 48.63  ? 191 SER C N   1 
ATOM 5057 C CA  . SER C 3 191 ? 162.909 249.069 344.831 1.00 47.14  ? 191 SER C CA  1 
ATOM 5058 C C   . SER C 3 191 ? 162.743 247.574 344.616 1.00 45.67  ? 191 SER C C   1 
ATOM 5059 O O   . SER C 3 191 ? 162.755 247.087 343.482 1.00 46.24  ? 191 SER C O   1 
ATOM 5060 C CB  . SER C 3 191 ? 161.529 249.724 344.887 1.00 50.93  ? 191 SER C CB  1 
ATOM 5061 O OG  . SER C 3 191 ? 161.623 251.083 345.268 1.00 55.17  ? 191 SER C OG  1 
ATOM 5062 N N   . VAL C 3 192 ? 162.583 246.853 345.724 1.00 48.59  ? 192 VAL C N   1 
ATOM 5063 C CA  . VAL C 3 192 ? 162.319 245.419 345.706 1.00 41.16  ? 192 VAL C CA  1 
ATOM 5064 C C   . VAL C 3 192 ? 161.000 245.160 346.420 1.00 44.04  ? 192 VAL C C   1 
ATOM 5065 O O   . VAL C 3 192 ? 160.797 245.625 347.547 1.00 46.82  ? 192 VAL C O   1 
ATOM 5066 C CB  . VAL C 3 192 ? 163.461 244.623 346.360 1.00 45.00  ? 192 VAL C CB  1 
ATOM 5067 C CG1 . VAL C 3 192 ? 163.243 243.137 346.173 1.00 43.66  ? 192 VAL C CG1 1 
ATOM 5068 C CG2 . VAL C 3 192 ? 164.795 245.038 345.775 1.00 45.99  ? 192 VAL C CG2 1 
ATOM 5069 N N   . PHE C 3 193 ? 160.110 244.408 345.767 1.00 51.79  ? 193 PHE C N   1 
ATOM 5070 C CA  . PHE C 3 193 ? 158.779 244.113 346.277 1.00 43.91  ? 193 PHE C CA  1 
ATOM 5071 C C   . PHE C 3 193 ? 158.542 242.609 346.305 1.00 46.03  ? 193 PHE C C   1 
ATOM 5072 O O   . PHE C 3 193 ? 159.105 241.858 345.505 1.00 45.06  ? 193 PHE C O   1 
ATOM 5073 C CB  . PHE C 3 193 ? 157.681 244.760 345.417 1.00 45.92  ? 193 PHE C CB  1 
ATOM 5074 C CG  . PHE C 3 193 ? 157.647 246.257 345.484 1.00 46.88  ? 193 PHE C CG  1 
ATOM 5075 C CD1 . PHE C 3 193 ? 158.373 247.018 344.592 1.00 47.07  ? 193 PHE C CD1 1 
ATOM 5076 C CD2 . PHE C 3 193 ? 156.867 246.902 346.422 1.00 48.68  ? 193 PHE C CD2 1 
ATOM 5077 C CE1 . PHE C 3 193 ? 158.336 248.389 344.648 1.00 46.94  ? 193 PHE C CE1 1 
ATOM 5078 C CE2 . PHE C 3 193 ? 156.828 248.270 346.481 1.00 44.68  ? 193 PHE C CE2 1 
ATOM 5079 C CZ  . PHE C 3 193 ? 157.563 249.015 345.593 1.00 45.81  ? 193 PHE C CZ  1 
ATOM 5080 N N   . TYR C 3 194 ? 157.673 242.186 347.222 1.00 48.86  ? 194 TYR C N   1 
ATOM 5081 C CA  . TYR C 3 194 ? 157.207 240.802 347.312 1.00 45.83  ? 194 TYR C CA  1 
ATOM 5082 C C   . TYR C 3 194 ? 156.147 240.568 346.245 1.00 46.99  ? 194 TYR C C   1 
ATOM 5083 O O   . TYR C 3 194 ? 154.965 240.840 346.448 1.00 48.17  ? 194 TYR C O   1 
ATOM 5084 C CB  . TYR C 3 194 ? 156.623 240.514 348.688 1.00 46.93  ? 194 TYR C CB  1 
ATOM 5085 C CG  . TYR C 3 194 ? 157.590 240.020 349.730 1.00 43.69  ? 194 TYR C CG  1 
ATOM 5086 C CD1 . TYR C 3 194 ? 158.195 238.784 349.612 1.00 45.39  ? 194 TYR C CD1 1 
ATOM 5087 C CD2 . TYR C 3 194 ? 157.861 240.774 350.858 1.00 47.67  ? 194 TYR C CD2 1 
ATOM 5088 C CE1 . TYR C 3 194 ? 159.063 238.327 350.572 1.00 48.29  ? 194 TYR C CE1 1 
ATOM 5089 C CE2 . TYR C 3 194 ? 158.727 240.325 351.821 1.00 46.92  ? 194 TYR C CE2 1 
ATOM 5090 C CZ  . TYR C 3 194 ? 159.324 239.101 351.674 1.00 47.37  ? 194 TYR C CZ  1 
ATOM 5091 O OH  . TYR C 3 194 ? 160.188 238.654 352.640 1.00 57.99  ? 194 TYR C OH  1 
ATOM 5092 N N   . GLN C 3 195 ? 156.564 240.054 345.090 1.00 49.95  ? 195 GLN C N   1 
ATOM 5093 C CA  . GLN C 3 195 ? 155.585 239.601 344.108 1.00 46.37  ? 195 GLN C CA  1 
ATOM 5094 C C   . GLN C 3 195 ? 154.828 238.388 344.623 1.00 40.60  ? 195 GLN C C   1 
ATOM 5095 O O   . GLN C 3 195 ? 153.623 238.253 344.389 1.00 38.64  ? 195 GLN C O   1 
ATOM 5096 C CB  . GLN C 3 195 ? 156.277 239.280 342.784 1.00 48.53  ? 195 GLN C CB  1 
ATOM 5097 C CG  . GLN C 3 195 ? 155.451 238.450 341.807 1.00 42.41  ? 195 GLN C CG  1 
ATOM 5098 C CD  . GLN C 3 195 ? 154.124 239.087 341.461 1.00 54.28  ? 195 GLN C CD  1 
ATOM 5099 O OE1 . GLN C 3 195 ? 154.044 239.940 340.580 1.00 57.14  ? 195 GLN C OE1 1 
ATOM 5100 N NE2 . GLN C 3 195 ? 153.071 238.675 342.151 1.00 53.00  ? 195 GLN C NE2 1 
ATOM 5101 N N   . THR C 3 196 ? 155.519 237.504 345.333 1.00 54.33  ? 196 THR C N   1 
ATOM 5102 C CA  . THR C 3 196 ? 154.961 236.247 345.800 1.00 52.44  ? 196 THR C CA  1 
ATOM 5103 C C   . THR C 3 196 ? 155.611 235.902 347.131 1.00 53.15  ? 196 THR C C   1 
ATOM 5104 O O   . THR C 3 196 ? 156.742 236.308 347.403 1.00 59.03  ? 196 THR C O   1 
ATOM 5105 C CB  . THR C 3 196 ? 155.203 235.131 344.777 1.00 49.67  ? 196 THR C CB  1 
ATOM 5106 O OG1 . THR C 3 196 ? 154.474 235.406 343.576 1.00 50.66  ? 196 THR C OG1 1 
ATOM 5107 C CG2 . THR C 3 196 ? 154.768 233.808 345.318 1.00 48.62  ? 196 THR C CG2 1 
ATOM 5108 N N   . ARG C 3 197 ? 154.892 235.154 347.960 1.00 55.18  ? 197 ARG C N   1 
ATOM 5109 C CA  . ARG C 3 197 ? 155.454 234.717 349.226 1.00 55.55  ? 197 ARG C CA  1 
ATOM 5110 C C   . ARG C 3 197 ? 156.550 233.680 348.990 1.00 56.28  ? 197 ARG C C   1 
ATOM 5111 O O   . ARG C 3 197 ? 156.745 233.179 347.880 1.00 58.32  ? 197 ARG C O   1 
ATOM 5112 C CB  . ARG C 3 197 ? 154.365 234.144 350.127 1.00 59.98  ? 197 ARG C CB  1 
ATOM 5113 C CG  . ARG C 3 197 ? 153.279 235.139 350.469 1.00 60.57  ? 197 ARG C CG  1 
ATOM 5114 C CD  . ARG C 3 197 ? 152.273 234.565 351.450 1.00 62.91  ? 197 ARG C CD  1 
ATOM 5115 N NE  . ARG C 3 197 ? 151.284 235.559 351.850 1.00 68.16  ? 197 ARG C NE  1 
ATOM 5116 C CZ  . ARG C 3 197 ? 151.433 236.407 352.860 1.00 69.34  ? 197 ARG C CZ  1 
ATOM 5117 N NH1 . ARG C 3 197 ? 152.523 236.407 353.610 1.00 68.25  ? 197 ARG C NH1 1 
ATOM 5118 N NH2 . ARG C 3 197 ? 150.465 237.280 353.123 1.00 64.41  ? 197 ARG C NH2 1 
ATOM 5119 N N   . ILE C 3 198 ? 157.284 233.370 350.053 1.00 49.59  ? 198 ILE C N   1 
ATOM 5120 C CA  . ILE C 3 198 ? 158.385 232.415 350.005 1.00 48.71  ? 198 ILE C CA  1 
ATOM 5121 C C   . ILE C 3 198 ? 157.915 231.107 350.625 1.00 48.85  ? 198 ILE C C   1 
ATOM 5122 O O   . ILE C 3 198 ? 157.433 231.089 351.764 1.00 50.37  ? 198 ILE C O   1 
ATOM 5123 C CB  . ILE C 3 198 ? 159.624 232.956 350.736 1.00 48.55  ? 198 ILE C CB  1 
ATOM 5124 C CG1 . ILE C 3 198 ? 160.033 234.318 350.170 1.00 50.32  ? 198 ILE C CG1 1 
ATOM 5125 C CG2 . ILE C 3 198 ? 160.773 231.977 350.622 1.00 50.00  ? 198 ILE C CG2 1 
ATOM 5126 C CD1 . ILE C 3 198 ? 160.530 234.276 348.740 1.00 53.20  ? 198 ILE C CD1 1 
ATOM 5127 N N   . VAL C 3 199 ? 158.061 230.013 349.883 1.00 47.07  ? 199 VAL C N   1 
ATOM 5128 C CA  . VAL C 3 199 ? 157.566 228.703 350.285 1.00 45.55  ? 199 VAL C CA  1 
ATOM 5129 C C   . VAL C 3 199 ? 158.752 227.798 350.579 1.00 45.06  ? 199 VAL C C   1 
ATOM 5130 O O   . VAL C 3 199 ? 159.734 227.781 349.830 1.00 48.92  ? 199 VAL C O   1 
ATOM 5131 C CB  . VAL C 3 199 ? 156.658 228.084 349.205 1.00 48.55  ? 199 VAL C CB  1 
ATOM 5132 C CG1 . VAL C 3 199 ? 155.445 228.960 348.971 1.00 47.19  ? 199 VAL C CG1 1 
ATOM 5133 C CG2 . VAL C 3 199 ? 157.422 227.880 347.912 1.00 47.62  ? 199 VAL C CG2 1 
ATOM 5134 N N   . VAL C 3 200 ? 158.655 227.046 351.671 1.00 47.18  ? 200 VAL C N   1 
ATOM 5135 C CA  . VAL C 3 200 ? 159.710 226.134 352.102 1.00 45.62  ? 200 VAL C CA  1 
ATOM 5136 C C   . VAL C 3 200 ? 159.107 224.744 352.271 1.00 47.29  ? 200 VAL C C   1 
ATOM 5137 O O   . VAL C 3 200 ? 157.920 224.624 352.599 1.00 49.00  ? 200 VAL C O   1 
ATOM 5138 C CB  . VAL C 3 200 ? 160.365 226.620 353.402 1.00 43.88  ? 200 VAL C CB  1 
ATOM 5139 C CG1 . VAL C 3 200 ? 161.126 227.905 353.157 1.00 42.53  ? 200 VAL C CG1 1 
ATOM 5140 C CG2 . VAL C 3 200 ? 159.317 226.821 354.481 1.00 42.23  ? 200 VAL C CG2 1 
ATOM 5141 N N   . PRO C 3 201 ? 159.877 223.674 352.075 1.00 45.84  ? 201 PRO C N   1 
ATOM 5142 C CA  . PRO C 3 201 ? 159.283 222.333 352.036 1.00 45.59  ? 201 PRO C CA  1 
ATOM 5143 C C   . PRO C 3 201 ? 159.009 221.730 353.401 1.00 47.36  ? 201 PRO C C   1 
ATOM 5144 O O   . PRO C 3 201 ? 158.051 220.969 353.564 1.00 59.73  ? 201 PRO C O   1 
ATOM 5145 C CB  . PRO C 3 201 ? 160.341 221.521 351.289 1.00 43.42  ? 201 PRO C CB  1 
ATOM 5146 C CG  . PRO C 3 201 ? 161.599 222.146 351.702 1.00 45.22  ? 201 PRO C CG  1 
ATOM 5147 C CD  . PRO C 3 201 ? 161.323 223.622 351.815 1.00 44.78  ? 201 PRO C CD  1 
ATOM 5148 N N   . LEU C 3 202 ? 159.840 222.049 354.382 1.00 39.96  ? 202 LEU C N   1 
ATOM 5149 C CA  . LEU C 3 202 ? 159.840 221.334 355.649 1.00 39.26  ? 202 LEU C CA  1 
ATOM 5150 C C   . LEU C 3 202 ? 160.233 222.322 356.740 1.00 47.78  ? 202 LEU C C   1 
ATOM 5151 O O   . LEU C 3 202 ? 160.077 223.535 356.577 1.00 55.13  ? 202 LEU C O   1 
ATOM 5152 C CB  . LEU C 3 202 ? 160.757 220.102 355.552 1.00 48.31  ? 202 LEU C CB  1 
ATOM 5153 C CG  . LEU C 3 202 ? 160.070 218.818 355.087 1.00 41.93  ? 202 LEU C CG  1 
ATOM 5154 C CD1 . LEU C 3 202 ? 161.087 217.819 354.584 1.00 41.59  ? 202 LEU C CD1 1 
ATOM 5155 C CD2 . LEU C 3 202 ? 159.252 218.218 356.214 1.00 40.33  ? 202 LEU C CD2 1 
ATOM 5156 N N   . SER C 3 203 ? 160.726 221.805 357.863 1.00 53.07  ? 203 SER C N   1 
ATOM 5157 C CA  . SER C 3 203 ? 161.166 222.632 358.980 1.00 51.18  ? 203 SER C CA  1 
ATOM 5158 C C   . SER C 3 203 ? 162.296 223.586 358.601 1.00 49.47  ? 203 SER C C   1 
ATOM 5159 O O   . SER C 3 203 ? 162.799 224.318 359.458 1.00 51.36  ? 203 SER C O   1 
ATOM 5160 C CB  . SER C 3 203 ? 161.610 221.739 360.135 1.00 48.83  ? 203 SER C CB  1 
ATOM 5161 O OG  . SER C 3 203 ? 162.464 220.714 359.668 1.00 50.62  ? 203 SER C OG  1 
ATOM 5162 N N   . THR C 3 204 ? 162.719 223.570 357.336 1.00 45.47  ? 204 THR C N   1 
ATOM 5163 C CA  . THR C 3 204 ? 163.669 224.534 356.798 1.00 45.26  ? 204 THR C CA  1 
ATOM 5164 C C   . THR C 3 204 ? 163.387 225.921 357.361 1.00 47.11  ? 204 THR C C   1 
ATOM 5165 O O   . THR C 3 204 ? 162.221 226.328 357.433 1.00 37.42  ? 204 THR C O   1 
ATOM 5166 C CB  . THR C 3 204 ? 163.583 224.556 355.272 1.00 41.23  ? 204 THR C CB  1 
ATOM 5167 O OG1 . THR C 3 204 ? 164.009 223.294 354.751 1.00 45.54  ? 204 THR C OG1 1 
ATOM 5168 C CG2 . THR C 3 204 ? 164.452 225.649 354.692 1.00 48.46  ? 204 THR C CG2 1 
ATOM 5169 N N   . PRO C 3 205 ? 164.406 226.672 357.783 1.00 54.55  ? 205 PRO C N   1 
ATOM 5170 C CA  . PRO C 3 205 ? 164.146 228.001 358.346 1.00 50.80  ? 205 PRO C CA  1 
ATOM 5171 C C   . PRO C 3 205 ? 163.468 228.907 357.332 1.00 51.62  ? 205 PRO C C   1 
ATOM 5172 O O   . PRO C 3 205 ? 163.764 228.867 356.137 1.00 55.14  ? 205 PRO C O   1 
ATOM 5173 C CB  . PRO C 3 205 ? 165.542 228.512 358.713 1.00 47.72  ? 205 PRO C CB  1 
ATOM 5174 C CG  . PRO C 3 205 ? 166.380 227.302 358.810 1.00 46.36  ? 205 PRO C CG  1 
ATOM 5175 C CD  . PRO C 3 205 ? 165.844 226.357 357.797 1.00 46.68  ? 205 PRO C CD  1 
ATOM 5176 N N   . ARG C 3 206 ? 162.554 229.739 357.825 1.00 55.32  ? 206 ARG C N   1 
ATOM 5177 C CA  . ARG C 3 206 ? 161.761 230.618 356.982 1.00 56.94  ? 206 ARG C CA  1 
ATOM 5178 C C   . ARG C 3 206 ? 162.334 232.028 356.906 1.00 60.98  ? 206 ARG C C   1 
ATOM 5179 O O   . ARG C 3 206 ? 161.693 232.920 356.343 1.00 63.13  ? 206 ARG C O   1 
ATOM 5180 C CB  . ARG C 3 206 ? 160.319 230.653 357.484 1.00 54.68  ? 206 ARG C CB  1 
ATOM 5181 C CG  . ARG C 3 206 ? 159.630 229.306 357.400 1.00 58.97  ? 206 ARG C CG  1 
ATOM 5182 C CD  . ARG C 3 206 ? 158.165 229.377 357.772 1.00 61.72  ? 206 ARG C CD  1 
ATOM 5183 N NE  . ARG C 3 206 ? 157.507 228.090 357.583 1.00 63.98  ? 206 ARG C NE  1 
ATOM 5184 C CZ  . ARG C 3 206 ? 156.204 227.881 357.721 1.00 64.95  ? 206 ARG C CZ  1 
ATOM 5185 N NH1 . ARG C 3 206 ? 155.378 228.858 358.058 1.00 62.41  ? 206 ARG C NH1 1 
ATOM 5186 N NH2 . ARG C 3 206 ? 155.717 226.663 357.511 1.00 61.47  ? 206 ARG C NH2 1 
ATOM 5187 N N   . GLU C 3 207 ? 163.527 232.246 357.458 1.00 60.53  ? 207 GLU C N   1 
ATOM 5188 C CA  . GLU C 3 207 ? 164.193 233.544 357.435 1.00 56.77  ? 207 GLU C CA  1 
ATOM 5189 C C   . GLU C 3 207 ? 165.398 233.455 356.512 1.00 59.44  ? 207 GLU C C   1 
ATOM 5190 O O   . GLU C 3 207 ? 166.322 232.676 356.764 1.00 63.04  ? 207 GLU C O   1 
ATOM 5191 C CB  . GLU C 3 207 ? 164.614 233.966 358.839 1.00 56.46  ? 207 GLU C CB  1 
ATOM 5192 C CG  . GLU C 3 207 ? 163.499 234.588 359.650 1.00 62.42  ? 207 GLU C CG  1 
ATOM 5193 C CD  . GLU C 3 207 ? 162.313 233.666 359.815 1.00 67.51  ? 207 GLU C CD  1 
ATOM 5194 O OE1 . GLU C 3 207 ? 162.483 232.442 359.645 1.00 67.83  ? 207 GLU C OE1 1 
ATOM 5195 O OE2 . GLU C 3 207 ? 161.209 234.164 360.115 1.00 68.62  ? 207 GLU C OE2 1 
ATOM 5196 N N   . MET C 3 208 ? 165.394 234.258 355.455 1.00 56.09  ? 208 MET C N   1 
ATOM 5197 C CA  . MET C 3 208 ? 166.480 234.300 354.489 1.00 50.26  ? 208 MET C CA  1 
ATOM 5198 C C   . MET C 3 208 ? 167.175 235.653 354.546 1.00 53.22  ? 208 MET C C   1 
ATOM 5199 O O   . MET C 3 208 ? 166.704 236.594 355.186 1.00 57.59  ? 208 MET C O   1 
ATOM 5200 C CB  . MET C 3 208 ? 165.966 234.050 353.069 1.00 50.57  ? 208 MET C CB  1 
ATOM 5201 C CG  . MET C 3 208 ? 164.519 233.593 352.982 1.00 52.50  ? 208 MET C CG  1 
ATOM 5202 S SD  . MET C 3 208 ? 164.223 232.003 353.764 1.00 72.68  ? 208 MET C SD  1 
ATOM 5203 C CE  . MET C 3 208 ? 165.174 230.925 352.697 1.00 60.72  ? 208 MET C CE  1 
ATOM 5204 N N   . ASP C 3 209 ? 168.301 235.740 353.847 1.00 48.56  ? 209 ASP C N   1 
ATOM 5205 C CA  . ASP C 3 209 ? 169.064 236.971 353.720 1.00 46.63  ? 209 ASP C CA  1 
ATOM 5206 C C   . ASP C 3 209 ? 169.381 237.227 352.256 1.00 47.79  ? 209 ASP C C   1 
ATOM 5207 O O   . ASP C 3 209 ? 169.567 236.292 351.475 1.00 50.65  ? 209 ASP C O   1 
ATOM 5208 C CB  . ASP C 3 209 ? 170.368 236.902 354.513 1.00 51.63  ? 209 ASP C CB  1 
ATOM 5209 C CG  . ASP C 3 209 ? 170.139 236.840 356.005 1.00 59.30  ? 209 ASP C CG  1 
ATOM 5210 O OD1 . ASP C 3 209 ? 169.204 237.508 356.491 1.00 59.22  ? 209 ASP C OD1 1 
ATOM 5211 O OD2 . ASP C 3 209 ? 170.895 236.124 356.693 1.00 56.03  ? 209 ASP C OD2 1 
ATOM 5212 N N   . ILE C 3 210 ? 169.437 238.502 351.887 1.00 50.73  ? 210 ILE C N   1 
ATOM 5213 C CA  . ILE C 3 210 ? 169.886 238.908 350.562 1.00 48.90  ? 210 ILE C CA  1 
ATOM 5214 C C   . ILE C 3 210 ? 170.910 240.021 350.713 1.00 47.35  ? 210 ILE C C   1 
ATOM 5215 O O   . ILE C 3 210 ? 170.798 240.869 351.606 1.00 49.52  ? 210 ILE C O   1 
ATOM 5216 C CB  . ILE C 3 210 ? 168.721 239.353 349.653 1.00 45.48  ? 210 ILE C CB  1 
ATOM 5217 C CG1 . ILE C 3 210 ? 168.019 240.582 350.214 1.00 49.43  ? 210 ILE C CG1 1 
ATOM 5218 C CG2 . ILE C 3 210 ? 167.724 238.231 349.492 1.00 49.24  ? 210 ILE C CG2 1 
ATOM 5219 C CD1 . ILE C 3 210 ? 166.805 240.996 349.416 1.00 49.11  ? 210 ILE C CD1 1 
ATOM 5220 N N   . LEU C 3 211 ? 171.916 239.997 349.843 1.00 44.20  ? 211 LEU C N   1 
ATOM 5221 C CA  . LEU C 3 211 ? 172.989 240.979 349.809 1.00 40.89  ? 211 LEU C CA  1 
ATOM 5222 C C   . LEU C 3 211 ? 172.930 241.768 348.509 1.00 42.93  ? 211 LEU C C   1 
ATOM 5223 O O   . LEU C 3 211 ? 172.334 241.331 347.524 1.00 50.24  ? 211 LEU C O   1 
ATOM 5224 C CB  . LEU C 3 211 ? 174.358 240.302 349.934 1.00 40.81  ? 211 LEU C CB  1 
ATOM 5225 C CG  . LEU C 3 211 ? 174.548 239.288 351.063 1.00 41.21  ? 211 LEU C CG  1 
ATOM 5226 C CD1 . LEU C 3 211 ? 175.931 238.680 350.991 1.00 41.99  ? 211 LEU C CD1 1 
ATOM 5227 C CD2 . LEU C 3 211 ? 174.321 239.921 352.417 1.00 40.48  ? 211 LEU C CD2 1 
ATOM 5228 N N   . GLY C 3 212 ? 173.571 242.929 348.507 1.00 39.01  ? 212 GLY C N   1 
ATOM 5229 C CA  . GLY C 3 212 ? 173.588 243.786 347.338 1.00 25.86  ? 212 GLY C CA  1 
ATOM 5230 C C   . GLY C 3 212 ? 174.977 244.309 347.042 1.00 29.45  ? 212 GLY C C   1 
ATOM 5231 O O   . GLY C 3 212 ? 175.780 244.546 347.940 1.00 38.52  ? 212 GLY C O   1 
ATOM 5232 N N   . PHE C 3 213 ? 175.245 244.492 345.753 1.00 29.14  ? 213 PHE C N   1 
ATOM 5233 C CA  . PHE C 3 213 ? 176.520 244.991 345.262 1.00 32.06  ? 213 PHE C CA  1 
ATOM 5234 C C   . PHE C 3 213 ? 176.269 246.054 344.204 1.00 38.84  ? 213 PHE C C   1 
ATOM 5235 O O   . PHE C 3 213 ? 175.311 245.964 343.437 1.00 55.03  ? 213 PHE C O   1 
ATOM 5236 C CB  . PHE C 3 213 ? 177.360 243.862 344.667 1.00 35.53  ? 213 PHE C CB  1 
ATOM 5237 C CG  . PHE C 3 213 ? 177.500 242.672 345.569 1.00 39.59  ? 213 PHE C CG  1 
ATOM 5238 C CD1 . PHE C 3 213 ? 176.527 241.695 345.601 1.00 42.00  ? 213 PHE C CD1 1 
ATOM 5239 C CD2 . PHE C 3 213 ? 178.608 242.527 346.379 1.00 39.06  ? 213 PHE C CD2 1 
ATOM 5240 C CE1 . PHE C 3 213 ? 176.653 240.605 346.428 1.00 43.07  ? 213 PHE C CE1 1 
ATOM 5241 C CE2 . PHE C 3 213 ? 178.737 241.441 347.204 1.00 36.19  ? 213 PHE C CE2 1 
ATOM 5242 C CZ  . PHE C 3 213 ? 177.760 240.478 347.231 1.00 39.05  ? 213 PHE C CZ  1 
ATOM 5243 N N   . VAL C 3 214 ? 177.143 247.056 344.153 1.00 36.35  ? 214 VAL C N   1 
ATOM 5244 C CA  . VAL C 3 214 ? 176.998 248.175 343.228 1.00 36.22  ? 214 VAL C CA  1 
ATOM 5245 C C   . VAL C 3 214 ? 178.312 248.400 342.496 1.00 34.96  ? 214 VAL C C   1 
ATOM 5246 O O   . VAL C 3 214 ? 179.391 248.220 343.067 1.00 36.75  ? 214 VAL C O   1 
ATOM 5247 C CB  . VAL C 3 214 ? 176.558 249.463 343.953 1.00 41.45  ? 214 VAL C CB  1 
ATOM 5248 C CG1 . VAL C 3 214 ? 177.472 249.762 345.127 1.00 33.64  ? 214 VAL C CG1 1 
ATOM 5249 C CG2 . VAL C 3 214 ? 176.528 250.626 342.980 1.00 40.18  ? 214 VAL C CG2 1 
ATOM 5250 N N   . SER C 3 215 ? 178.219 248.801 341.232 1.00 35.78  ? 215 SER C N   1 
ATOM 5251 C CA  . SER C 3 215 ? 179.398 249.001 340.405 1.00 33.06  ? 215 SER C CA  1 
ATOM 5252 C C   . SER C 3 215 ? 179.086 250.029 339.327 1.00 39.90  ? 215 SER C C   1 
ATOM 5253 O O   . SER C 3 215 ? 177.928 250.376 339.087 1.00 52.01  ? 215 SER C O   1 
ATOM 5254 C CB  . SER C 3 215 ? 179.856 247.686 339.773 1.00 39.90  ? 215 SER C CB  1 
ATOM 5255 O OG  . SER C 3 215 ? 180.577 247.922 338.580 1.00 39.06  ? 215 SER C OG  1 
ATOM 5256 N N   . ALA C 3 216 ? 180.137 250.505 338.670 1.00 38.43  ? 216 ALA C N   1 
ATOM 5257 C CA  . ALA C 3 216 ? 180.025 251.460 337.579 1.00 31.50  ? 216 ALA C CA  1 
ATOM 5258 C C   . ALA C 3 216 ? 180.385 250.781 336.267 1.00 33.72  ? 216 ALA C C   1 
ATOM 5259 O O   . ALA C 3 216 ? 181.301 249.958 336.217 1.00 41.51  ? 216 ALA C O   1 
ATOM 5260 C CB  . ALA C 3 216 ? 180.937 252.663 337.810 1.00 36.63  ? 216 ALA C CB  1 
ATOM 5261 N N   . CYS C 3 217 ? 179.668 251.130 335.204 1.00 47.85  ? 217 CYS C N   1 
ATOM 5262 C CA  . CYS C 3 217 ? 179.890 250.510 333.909 1.00 49.31  ? 217 CYS C CA  1 
ATOM 5263 C C   . CYS C 3 217 ? 181.069 251.170 333.196 1.00 50.95  ? 217 CYS C C   1 
ATOM 5264 O O   . CYS C 3 217 ? 181.725 252.071 333.721 1.00 52.04  ? 217 CYS C O   1 
ATOM 5265 C CB  . CYS C 3 217 ? 178.619 250.579 333.069 1.00 45.36  ? 217 CYS C CB  1 
ATOM 5266 S SG  . CYS C 3 217 ? 177.265 249.581 333.720 1.00 66.31  ? 217 CYS C SG  1 
ATOM 5267 N N   . ASN C 3 218 ? 181.342 250.715 331.975 1.00 55.26  ? 218 ASN C N   1 
ATOM 5268 C CA  . ASN C 3 218 ? 182.517 251.134 331.222 1.00 55.65  ? 218 ASN C CA  1 
ATOM 5269 C C   . ASN C 3 218 ? 182.312 252.441 330.481 1.00 54.83  ? 218 ASN C C   1 
ATOM 5270 O O   . ASN C 3 218 ? 183.066 252.730 329.545 1.00 56.10  ? 218 ASN C O   1 
ATOM 5271 C CB  . ASN C 3 218 ? 182.919 250.042 330.231 1.00 59.73  ? 218 ASN C CB  1 
ATOM 5272 C CG  . ASN C 3 218 ? 181.966 249.941 329.063 1.00 59.09  ? 218 ASN C CG  1 
ATOM 5273 O OD1 . ASN C 3 218 ? 180.911 249.316 329.160 1.00 52.49  ? 218 ASN C OD1 1 
ATOM 5274 N ND2 . ASN C 3 218 ? 182.334 250.556 327.947 1.00 60.74  ? 218 ASN C ND2 1 
ATOM 5275 N N   . ASP C 3 219 ? 181.308 253.230 330.861 1.00 55.88  ? 219 ASP C N   1 
ATOM 5276 C CA  . ASP C 3 219 ? 181.094 254.555 330.293 1.00 52.49  ? 219 ASP C CA  1 
ATOM 5277 C C   . ASP C 3 219 ? 180.974 255.610 331.385 1.00 51.73  ? 219 ASP C C   1 
ATOM 5278 O O   . ASP C 3 219 ? 180.362 256.658 331.166 1.00 57.21  ? 219 ASP C O   1 
ATOM 5279 C CB  . ASP C 3 219 ? 179.853 254.564 329.398 1.00 54.14  ? 219 ASP C CB  1 
ATOM 5280 C CG  . ASP C 3 219 ? 178.610 254.074 330.114 1.00 52.43  ? 219 ASP C CG  1 
ATOM 5281 O OD1 . ASP C 3 219 ? 178.618 254.004 331.360 1.00 51.58  ? 219 ASP C OD1 1 
ATOM 5282 O OD2 . ASP C 3 219 ? 177.622 253.753 329.425 1.00 55.14  ? 219 ASP C OD2 1 
ATOM 5283 N N   . PHE C 3 220 ? 181.540 255.348 332.556 1.00 39.10  ? 220 PHE C N   1 
ATOM 5284 C CA  . PHE C 3 220 ? 181.516 256.280 333.668 1.00 35.15  ? 220 PHE C CA  1 
ATOM 5285 C C   . PHE C 3 220 ? 182.687 257.248 333.559 1.00 34.76  ? 220 PHE C C   1 
ATOM 5286 O O   . PHE C 3 220 ? 183.715 256.937 332.956 1.00 35.11  ? 220 PHE C O   1 
ATOM 5287 C CB  . PHE C 3 220 ? 181.585 255.518 334.988 1.00 36.22  ? 220 PHE C CB  1 
ATOM 5288 C CG  . PHE C 3 220 ? 180.881 256.191 336.116 1.00 28.65  ? 220 PHE C CG  1 
ATOM 5289 C CD1 . PHE C 3 220 ? 179.545 255.960 336.343 1.00 33.59  ? 220 PHE C CD1 1 
ATOM 5290 C CD2 . PHE C 3 220 ? 181.558 257.042 336.960 1.00 34.68  ? 220 PHE C CD2 1 
ATOM 5291 C CE1 . PHE C 3 220 ? 178.893 256.574 337.384 1.00 37.15  ? 220 PHE C CE1 1 
ATOM 5292 C CE2 . PHE C 3 220 ? 180.910 257.656 338.002 1.00 39.51  ? 220 PHE C CE2 1 
ATOM 5293 C CZ  . PHE C 3 220 ? 179.576 257.421 338.214 1.00 39.95  ? 220 PHE C CZ  1 
ATOM 5294 N N   . SER C 3 221 ? 182.519 258.434 334.136 1.00 25.58  ? 221 SER C N   1 
ATOM 5295 C CA  . SER C 3 221 ? 183.583 259.427 334.104 1.00 23.03  ? 221 SER C CA  1 
ATOM 5296 C C   . SER C 3 221 ? 183.363 260.438 335.215 1.00 28.10  ? 221 SER C C   1 
ATOM 5297 O O   . SER C 3 221 ? 182.245 260.623 335.703 1.00 35.86  ? 221 SER C O   1 
ATOM 5298 C CB  . SER C 3 221 ? 183.650 260.132 332.752 1.00 32.16  ? 221 SER C CB  1 
ATOM 5299 O OG  . SER C 3 221 ? 183.967 259.216 331.726 1.00 43.55  ? 221 SER C OG  1 
ATOM 5300 N N   . VAL C 3 222 ? 184.458 261.096 335.599 1.00 31.20  ? 222 VAL C N   1 
ATOM 5301 C CA  . VAL C 3 222 ? 184.452 262.143 336.610 1.00 33.19  ? 222 VAL C CA  1 
ATOM 5302 C C   . VAL C 3 222 ? 185.389 263.253 336.154 1.00 30.60  ? 222 VAL C C   1 
ATOM 5303 O O   . VAL C 3 222 ? 186.225 263.065 335.269 1.00 32.74  ? 222 VAL C O   1 
ATOM 5304 C CB  . VAL C 3 222 ? 184.878 261.616 337.997 1.00 21.49  ? 222 VAL C CB  1 
ATOM 5305 C CG1 . VAL C 3 222 ? 183.962 260.502 338.442 1.00 30.46  ? 222 VAL C CG1 1 
ATOM 5306 C CG2 . VAL C 3 222 ? 186.307 261.139 337.958 1.00 25.97  ? 222 VAL C CG2 1 
ATOM 5307 N N   . ARG C 3 223 ? 185.238 264.427 336.763 1.00 33.90  ? 223 ARG C N   1 
ATOM 5308 C CA  . ARG C 3 223 ? 186.140 265.533 336.464 1.00 36.67  ? 223 ARG C CA  1 
ATOM 5309 C C   . ARG C 3 223 ? 185.997 266.636 337.506 1.00 28.81  ? 223 ARG C C   1 
ATOM 5310 O O   . ARG C 3 223 ? 185.076 266.638 338.328 1.00 33.31  ? 223 ARG C O   1 
ATOM 5311 C CB  . ARG C 3 223 ? 185.898 266.091 335.060 1.00 43.31  ? 223 ARG C CB  1 
ATOM 5312 C CG  . ARG C 3 223 ? 184.679 266.967 334.932 1.00 44.45  ? 223 ARG C CG  1 
ATOM 5313 C CD  . ARG C 3 223 ? 184.663 267.694 333.618 1.00 39.37  ? 223 ARG C CD  1 
ATOM 5314 N NE  . ARG C 3 223 ? 183.635 268.722 333.616 1.00 34.02  ? 223 ARG C NE  1 
ATOM 5315 C CZ  . ARG C 3 223 ? 183.152 269.298 332.527 1.00 40.82  ? 223 ARG C CZ  1 
ATOM 5316 N NH1 . ARG C 3 223 ? 183.582 268.967 331.322 1.00 43.29  ? 223 ARG C NH1 1 
ATOM 5317 N NH2 . ARG C 3 223 ? 182.208 270.224 332.650 1.00 41.38  ? 223 ARG C NH2 1 
ATOM 5318 N N   . LEU C 3 224 ? 186.906 267.612 337.404 1.00 18.65  ? 224 LEU C N   1 
ATOM 5319 C CA  . LEU C 3 224 ? 187.053 268.733 338.333 1.00 29.71  ? 224 LEU C CA  1 
ATOM 5320 C C   . LEU C 3 224 ? 187.407 268.244 339.741 1.00 33.90  ? 224 LEU C C   1 
ATOM 5321 O O   . LEU C 3 224 ? 186.616 268.307 340.680 1.00 40.70  ? 224 LEU C O   1 
ATOM 5322 C CB  . LEU C 3 224 ? 185.800 269.609 338.352 1.00 38.41  ? 224 LEU C CB  1 
ATOM 5323 C CG  . LEU C 3 224 ? 185.932 270.866 339.219 1.00 33.59  ? 224 LEU C CG  1 
ATOM 5324 C CD1 . LEU C 3 224 ? 187.174 271.660 338.861 1.00 17.84  ? 224 LEU C CD1 1 
ATOM 5325 C CD2 . LEU C 3 224 ? 184.701 271.737 339.091 1.00 36.63  ? 224 LEU C CD2 1 
ATOM 5326 N N   . LEU C 3 225 ? 188.637 267.747 339.847 1.00 22.15  ? 225 LEU C N   1 
ATOM 5327 C CA  . LEU C 3 225 ? 189.125 267.169 341.091 1.00 22.76  ? 225 LEU C CA  1 
ATOM 5328 C C   . LEU C 3 225 ? 188.949 268.127 342.257 1.00 18.29  ? 225 LEU C C   1 
ATOM 5329 O O   . LEU C 3 225 ? 189.281 269.308 342.165 1.00 31.94  ? 225 LEU C O   1 
ATOM 5330 C CB  . LEU C 3 225 ? 190.600 266.794 340.939 1.00 34.18  ? 225 LEU C CB  1 
ATOM 5331 C CG  . LEU C 3 225 ? 191.167 265.839 341.991 1.00 29.47  ? 225 LEU C CG  1 
ATOM 5332 C CD1 . LEU C 3 225 ? 192.286 265.031 341.390 1.00 29.53  ? 225 LEU C CD1 1 
ATOM 5333 C CD2 . LEU C 3 225 ? 191.657 266.582 343.218 1.00 29.68  ? 225 LEU C CD2 1 
ATOM 5334 N N   . ARG C 3 226 ? 188.422 267.603 343.358 1.00 29.60  ? 226 ARG C N   1 
ATOM 5335 C CA  . ARG C 3 226 ? 188.220 268.359 344.584 1.00 26.09  ? 226 ARG C CA  1 
ATOM 5336 C C   . ARG C 3 226 ? 188.538 267.464 345.766 1.00 41.54  ? 226 ARG C C   1 
ATOM 5337 O O   . ARG C 3 226 ? 188.010 266.354 345.859 1.00 63.52  ? 226 ARG C O   1 
ATOM 5338 C CB  . ARG C 3 226 ? 186.782 268.865 344.696 1.00 30.80  ? 226 ARG C CB  1 
ATOM 5339 C CG  . ARG C 3 226 ? 186.421 269.388 346.070 1.00 37.51  ? 226 ARG C CG  1 
ATOM 5340 C CD  . ARG C 3 226 ? 185.044 270.010 346.075 1.00 40.03  ? 226 ARG C CD  1 
ATOM 5341 N NE  . ARG C 3 226 ? 184.003 269.038 345.767 1.00 38.12  ? 226 ARG C NE  1 
ATOM 5342 C CZ  . ARG C 3 226 ? 182.722 269.338 345.608 1.00 41.15  ? 226 ARG C CZ  1 
ATOM 5343 N NH1 . ARG C 3 226 ? 182.287 270.582 345.702 1.00 43.26  ? 226 ARG C NH1 1 
ATOM 5344 N NH2 . ARG C 3 226 ? 181.856 268.364 345.347 1.00 38.12  ? 226 ARG C NH2 1 
ATOM 5345 N N   . ASP C 3 227 ? 189.385 267.945 346.668 1.00 42.83  ? 227 ASP C N   1 
ATOM 5346 C CA  . ASP C 3 227 ? 189.737 267.211 347.874 1.00 40.25  ? 227 ASP C CA  1 
ATOM 5347 C C   . ASP C 3 227 ? 189.454 268.086 349.083 1.00 45.83  ? 227 ASP C C   1 
ATOM 5348 O O   . ASP C 3 227 ? 189.827 269.262 349.100 1.00 53.44  ? 227 ASP C O   1 
ATOM 5349 C CB  . ASP C 3 227 ? 191.204 266.787 347.855 1.00 44.82  ? 227 ASP C CB  1 
ATOM 5350 C CG  . ASP C 3 227 ? 191.579 265.950 349.059 1.00 56.71  ? 227 ASP C CG  1 
ATOM 5351 O OD1 . ASP C 3 227 ? 190.691 265.679 349.893 1.00 57.23  ? 227 ASP C OD1 1 
ATOM 5352 O OD2 . ASP C 3 227 ? 192.760 265.563 349.175 1.00 54.95  ? 227 ASP C OD2 1 
ATOM 5353 N N   . THR C 3 228 ? 188.801 267.510 350.095 1.00 56.61  ? 228 THR C N   1 
ATOM 5354 C CA  . THR C 3 228 ? 188.428 268.253 351.294 1.00 61.13  ? 228 THR C CA  1 
ATOM 5355 C C   . THR C 3 228 ? 188.822 267.519 352.571 1.00 63.73  ? 228 THR C C   1 
ATOM 5356 O O   . THR C 3 228 ? 188.360 267.890 353.654 1.00 62.61  ? 228 THR C O   1 
ATOM 5357 C CB  . THR C 3 228 ? 186.924 268.533 351.315 1.00 62.43  ? 228 THR C CB  1 
ATOM 5358 O OG1 . THR C 3 228 ? 186.223 267.356 351.735 1.00 56.11  ? 228 THR C OG1 1 
ATOM 5359 C CG2 . THR C 3 228 ? 186.437 268.944 349.935 1.00 58.93  ? 228 THR C CG2 1 
ATOM 5360 N N   . THR C 3 229 ? 189.655 266.487 352.476 1.00 61.07  ? 229 THR C N   1 
ATOM 5361 C CA  . THR C 3 229 ? 190.032 265.732 353.663 1.00 60.82  ? 229 THR C CA  1 
ATOM 5362 C C   . THR C 3 229 ? 190.913 266.582 354.568 1.00 57.56  ? 229 THR C C   1 
ATOM 5363 O O   . THR C 3 229 ? 191.881 267.197 354.114 1.00 56.49  ? 229 THR C O   1 
ATOM 5364 C CB  . THR C 3 229 ? 190.755 264.439 353.278 1.00 62.46  ? 229 THR C CB  1 
ATOM 5365 O OG1 . THR C 3 229 ? 191.195 263.764 354.463 1.00 58.05  ? 229 THR C OG1 1 
ATOM 5366 C CG2 . THR C 3 229 ? 191.954 264.720 352.388 1.00 60.90  ? 229 THR C CG2 1 
ATOM 5367 N N   . HIS C 3 230 ? 190.571 266.618 355.851 1.00 63.19  ? 230 HIS C N   1 
ATOM 5368 C CA  . HIS C 3 230 ? 191.345 267.361 356.831 1.00 65.16  ? 230 HIS C CA  1 
ATOM 5369 C C   . HIS C 3 230 ? 191.063 266.788 358.210 1.00 69.61  ? 230 HIS C C   1 
ATOM 5370 O O   . HIS C 3 230 ? 189.909 266.523 358.553 1.00 67.33  ? 230 HIS C O   1 
ATOM 5371 C CB  . HIS C 3 230 ? 191.003 268.853 356.796 1.00 69.91  ? 230 HIS C CB  1 
ATOM 5372 C CG  . HIS C 3 230 ? 189.609 269.164 357.243 1.00 70.67  ? 230 HIS C CG  1 
ATOM 5373 N ND1 . HIS C 3 230 ? 189.334 269.807 358.430 1.00 71.00  ? 230 HIS C ND1 1 
ATOM 5374 C CD2 . HIS C 3 230 ? 188.411 268.920 356.661 1.00 69.57  ? 230 HIS C CD2 1 
ATOM 5375 C CE1 . HIS C 3 230 ? 188.027 269.947 358.559 1.00 69.72  ? 230 HIS C CE1 1 
ATOM 5376 N NE2 . HIS C 3 230 ? 187.444 269.417 357.500 1.00 70.47  ? 230 HIS C NE2 1 
ATOM 5377 N N   . ILE C 3 231 ? 192.126 266.593 358.994 1.00 78.74  ? 231 ILE C N   1 
ATOM 5378 C CA  . ILE C 3 231 ? 191.996 266.077 360.352 1.00 79.82  ? 231 ILE C CA  1 
ATOM 5379 C C   . ILE C 3 231 ? 191.955 267.184 361.386 1.00 79.86  ? 231 ILE C C   1 
ATOM 5380 O O   . ILE C 3 231 ? 191.990 266.896 362.590 1.00 79.38  ? 231 ILE C O   1 
ATOM 5381 C CB  . ILE C 3 231 ? 193.135 265.093 360.686 1.00 80.61  ? 231 ILE C CB  1 
ATOM 5382 C CG1 . ILE C 3 231 ? 194.491 265.808 360.696 1.00 78.10  ? 231 ILE C CG1 1 
ATOM 5383 C CG2 . ILE C 3 231 ? 193.147 263.949 359.695 1.00 78.80  ? 231 ILE C CG2 1 
ATOM 5384 C CD1 . ILE C 3 231 ? 194.941 266.267 362.065 1.00 76.31  ? 231 ILE C CD1 1 
ATOM 5385 N N   . GLU C 3 232 ? 191.888 268.441 360.958 1.00 85.14  ? 232 GLU C N   1 
ATOM 5386 C CA  . GLU C 3 232 ? 191.885 269.552 361.897 1.00 85.75  ? 232 GLU C CA  1 
ATOM 5387 C C   . GLU C 3 232 ? 190.788 269.366 362.937 1.00 87.04  ? 232 GLU C C   1 
ATOM 5388 O O   . GLU C 3 232 ? 189.783 268.694 362.692 1.00 85.21  ? 232 GLU C O   1 
ATOM 5389 C CB  . GLU C 3 232 ? 191.696 270.872 361.149 1.00 84.46  ? 232 GLU C CB  1 
ATOM 5390 C CG  . GLU C 3 232 ? 192.830 271.192 360.188 1.00 85.60  ? 232 GLU C CG  1 
ATOM 5391 C CD  . GLU C 3 232 ? 192.626 272.502 359.457 1.00 87.65  ? 232 GLU C CD  1 
ATOM 5392 O OE1 . GLU C 3 232 ? 191.486 273.012 359.457 1.00 85.36  ? 232 GLU C OE1 1 
ATOM 5393 O OE2 . GLU C 3 232 ? 193.605 273.022 358.881 1.00 84.52  ? 232 GLU C OE2 1 
ATOM 5394 N N   . GLN C 3 233 ? 190.994 269.966 364.103 1.00 92.69  ? 233 GLN C N   1 
ATOM 5395 C CA  . GLN C 3 233 ? 190.086 269.801 365.230 1.00 92.08  ? 233 GLN C CA  1 
ATOM 5396 C C   . GLN C 3 233 ? 189.367 271.109 365.539 1.00 90.49  ? 233 GLN C C   1 
ATOM 5397 O O   . GLN C 3 233 ? 189.975 272.179 365.536 1.00 90.52  ? 233 GLN C O   1 
ATOM 5398 C CB  . GLN C 3 233 ? 190.848 269.310 366.465 1.00 91.17  ? 233 GLN C CB  1 
ATOM 5399 C CG  . GLN C 3 233 ? 192.004 270.207 366.902 1.00 93.29  ? 233 GLN C CG  1 
ATOM 5400 C CD  . GLN C 3 233 ? 193.236 270.048 366.034 1.00 92.58  ? 233 GLN C CD  1 
ATOM 5401 O OE1 . GLN C 3 233 ? 193.732 268.939 365.835 1.00 93.19  ? 233 GLN C OE1 1 
ATOM 5402 N NE2 . GLN C 3 233 ? 193.731 271.158 365.501 1.00 89.51  ? 233 GLN C NE2 1 
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