data_9EZ0
# 
_entry.id   9EZ0 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9EZ0         pdb_00009ez0 10.2210/pdb9ez0/pdb 
WWPDB D_1292137795 ?            ?                   
EMDB  EMD-50066    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9EZ0 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-10 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        
'Poliovirus type 1 (strain Mahoney) expanded conformation stabilised virus-like particle (PV1 SC6b) from a yeast expression system.' 
_pdbx_database_related.db_id          EMD-50066 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              dave.stuart@strubi.ox.ac.uk 
_pdbx_contact_author.name_first         David 
_pdbx_contact_author.name_last          Stuart 
_pdbx_contact_author.name_mi            I. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3426-4210 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bahar, M.W.'      1 0000-0002-2350-2682 
'Sherry, L.'       2 0000-0002-4367-772X 
'Stonehouse, N.J.' 3 0000-0003-1146-5519 
'Rowlands, D.J.'   4 0000-0002-4742-9272 
'Fry, E.E.'        5 0000-0001-9754-5303 
'Stuart, D.I.'     6 0000-0002-3426-4210 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                831 
_citation.page_last                 831 
_citation.title                     
'Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-025-56118-z 
_citation.pdbx_database_id_PubMed   39827284 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sherry, L.'         1  0000-0002-4367-772X 
primary 'Bahar, M.W.'        2  0000-0002-2350-2682 
primary 'Porta, C.'          3  ?                   
primary 'Fox, H.'            4  ?                   
primary 'Grehan, K.'         5  0000-0003-3976-756X 
primary 'Nasta, V.'          6  ?                   
primary 'Duyvesteyn, H.M.E.' 7  ?                   
primary 'De Colibus, L.'     8  ?                   
primary 'Marsian, J.'        9  ?                   
primary 'Murdoch, I.'        10 ?                   
primary 'Ponndorf, D.'       11 ?                   
primary 'Kim, S.R.'          12 ?                   
primary 'Shah, S.'           13 ?                   
primary 'Carlyle, S.'        14 0000-0002-7158-8134 
primary 'Swanson, J.J.'      15 ?                   
primary 'Matthews, S.'       16 ?                   
primary 'Nicol, C.'          17 ?                   
primary 'Lomonossoff, G.P.'  18 0000-0003-0700-906X 
primary 'Macadam, A.J.'      19 0000-0002-8687-1573 
primary 'Fry, E.E.'          20 0000-0001-9754-5303 
primary 'Stuart, D.I.'       21 0000-0002-3426-4210 
primary 'Stonehouse, N.J.'   22 0000-0003-1146-5519 
primary 'Rowlands, D.J.'     23 0000-0002-4742-9272 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Capsid protein VP1' 33447.586 1 ? 'VP1 H248P'                     ? ? 
2 polymer man 'Capsid protein VP0' 37465.812 1 ? 'VP2 T94A, VP2 D126E, VP4 R18G' ? ? 
3 polymer man 'Capsid protein VP3' 26550.549 1 ? 'VP3 L119M, VP3 Q178L'          ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'P1D,Virion protein 1' 
2 VP4-VP2                
3 'P1C,Virion protein 3' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESF
FARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYV
PPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGIL
AVRVVNDPNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY
;
;GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESF
FARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYV
PPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGIL
AVRVVNDPNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY
;
A ? 
2 'polypeptide(L)' no no 
;MGAQVSSQKVGAHENSNGAYGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSD
RVLQLTLGNSTITAQEAANSVVAYGRWPEYLRDSEANPVDQPTEPEVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGL
FGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPA
RRFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITL
TIAPMCCEFNGLRNITLPRLQ
;
;MGAQVSSQKVGAHENSNGAYGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSD
RVLQLTLGNSTITAQEAANSVVAYGRWPEYLRDSEANPVDQPTEPEVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGL
FGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPA
RRFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITL
TIAPMCCEFNGLRNITLPRLQ
;
B ? 
3 'polypeptide(L)' no no 
;GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDD
PILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFMFCGSMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRLTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQ
;
;GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDD
PILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFMFCGSMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRLTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQ
;
C ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   LEU n 
1 3   GLY n 
1 4   GLN n 
1 5   MET n 
1 6   LEU n 
1 7   GLU n 
1 8   SER n 
1 9   MET n 
1 10  ILE n 
1 11  ASP n 
1 12  ASN n 
1 13  THR n 
1 14  VAL n 
1 15  ARG n 
1 16  GLU n 
1 17  THR n 
1 18  VAL n 
1 19  GLY n 
1 20  ALA n 
1 21  ALA n 
1 22  THR n 
1 23  SER n 
1 24  ARG n 
1 25  ASP n 
1 26  ALA n 
1 27  LEU n 
1 28  PRO n 
1 29  ASN n 
1 30  THR n 
1 31  GLU n 
1 32  ALA n 
1 33  SER n 
1 34  GLY n 
1 35  PRO n 
1 36  THR n 
1 37  HIS n 
1 38  SER n 
1 39  LYS n 
1 40  GLU n 
1 41  ILE n 
1 42  PRO n 
1 43  ALA n 
1 44  LEU n 
1 45  THR n 
1 46  ALA n 
1 47  VAL n 
1 48  GLU n 
1 49  THR n 
1 50  GLY n 
1 51  ALA n 
1 52  THR n 
1 53  ASN n 
1 54  PRO n 
1 55  LEU n 
1 56  VAL n 
1 57  PRO n 
1 58  SER n 
1 59  ASP n 
1 60  THR n 
1 61  VAL n 
1 62  GLN n 
1 63  THR n 
1 64  ARG n 
1 65  HIS n 
1 66  VAL n 
1 67  VAL n 
1 68  GLN n 
1 69  HIS n 
1 70  ARG n 
1 71  SER n 
1 72  ARG n 
1 73  SER n 
1 74  GLU n 
1 75  SER n 
1 76  SER n 
1 77  ILE n 
1 78  GLU n 
1 79  SER n 
1 80  PHE n 
1 81  PHE n 
1 82  ALA n 
1 83  ARG n 
1 84  GLY n 
1 85  ALA n 
1 86  CYS n 
1 87  VAL n 
1 88  THR n 
1 89  ILE n 
1 90  MET n 
1 91  THR n 
1 92  VAL n 
1 93  ASP n 
1 94  ASN n 
1 95  PRO n 
1 96  ALA n 
1 97  SER n 
1 98  THR n 
1 99  THR n 
1 100 ASN n 
1 101 LYS n 
1 102 ASP n 
1 103 LYS n 
1 104 LEU n 
1 105 PHE n 
1 106 ALA n 
1 107 VAL n 
1 108 TRP n 
1 109 LYS n 
1 110 ILE n 
1 111 THR n 
1 112 TYR n 
1 113 LYS n 
1 114 ASP n 
1 115 THR n 
1 116 VAL n 
1 117 GLN n 
1 118 LEU n 
1 119 ARG n 
1 120 ARG n 
1 121 LYS n 
1 122 LEU n 
1 123 GLU n 
1 124 PHE n 
1 125 PHE n 
1 126 THR n 
1 127 TYR n 
1 128 SER n 
1 129 ARG n 
1 130 PHE n 
1 131 ASP n 
1 132 MET n 
1 133 GLU n 
1 134 LEU n 
1 135 THR n 
1 136 PHE n 
1 137 VAL n 
1 138 VAL n 
1 139 THR n 
1 140 ALA n 
1 141 ASN n 
1 142 PHE n 
1 143 THR n 
1 144 GLU n 
1 145 THR n 
1 146 ASN n 
1 147 ASN n 
1 148 GLY n 
1 149 HIS n 
1 150 ALA n 
1 151 LEU n 
1 152 ASN n 
1 153 GLN n 
1 154 VAL n 
1 155 TYR n 
1 156 GLN n 
1 157 ILE n 
1 158 MET n 
1 159 TYR n 
1 160 VAL n 
1 161 PRO n 
1 162 PRO n 
1 163 GLY n 
1 164 ALA n 
1 165 PRO n 
1 166 VAL n 
1 167 PRO n 
1 168 GLU n 
1 169 LYS n 
1 170 TRP n 
1 171 ASP n 
1 172 ASP n 
1 173 TYR n 
1 174 THR n 
1 175 TRP n 
1 176 GLN n 
1 177 THR n 
1 178 SER n 
1 179 SER n 
1 180 ASN n 
1 181 PRO n 
1 182 SER n 
1 183 ILE n 
1 184 PHE n 
1 185 TYR n 
1 186 THR n 
1 187 TYR n 
1 188 GLY n 
1 189 THR n 
1 190 ALA n 
1 191 PRO n 
1 192 ALA n 
1 193 ARG n 
1 194 ILE n 
1 195 SER n 
1 196 VAL n 
1 197 PRO n 
1 198 TYR n 
1 199 VAL n 
1 200 GLY n 
1 201 ILE n 
1 202 SER n 
1 203 ASN n 
1 204 ALA n 
1 205 TYR n 
1 206 SER n 
1 207 HIS n 
1 208 PHE n 
1 209 TYR n 
1 210 ASP n 
1 211 GLY n 
1 212 PHE n 
1 213 SER n 
1 214 LYS n 
1 215 VAL n 
1 216 PRO n 
1 217 LEU n 
1 218 LYS n 
1 219 ASP n 
1 220 GLN n 
1 221 SER n 
1 222 ALA n 
1 223 ALA n 
1 224 LEU n 
1 225 GLY n 
1 226 ASP n 
1 227 SER n 
1 228 LEU n 
1 229 TYR n 
1 230 GLY n 
1 231 ALA n 
1 232 ALA n 
1 233 SER n 
1 234 LEU n 
1 235 ASN n 
1 236 ASP n 
1 237 PHE n 
1 238 GLY n 
1 239 ILE n 
1 240 LEU n 
1 241 ALA n 
1 242 VAL n 
1 243 ARG n 
1 244 VAL n 
1 245 VAL n 
1 246 ASN n 
1 247 ASP n 
1 248 PRO n 
1 249 ASN n 
1 250 PRO n 
1 251 THR n 
1 252 LYS n 
1 253 VAL n 
1 254 THR n 
1 255 SER n 
1 256 LYS n 
1 257 ILE n 
1 258 ARG n 
1 259 VAL n 
1 260 TYR n 
1 261 LEU n 
1 262 LYS n 
1 263 PRO n 
1 264 LYS n 
1 265 HIS n 
1 266 ILE n 
1 267 ARG n 
1 268 VAL n 
1 269 TRP n 
1 270 CYS n 
1 271 PRO n 
1 272 ARG n 
1 273 PRO n 
1 274 PRO n 
1 275 ARG n 
1 276 ALA n 
1 277 VAL n 
1 278 ALA n 
1 279 TYR n 
1 280 TYR n 
1 281 GLY n 
1 282 PRO n 
1 283 GLY n 
1 284 VAL n 
1 285 ASP n 
1 286 TYR n 
1 287 LYS n 
1 288 ASP n 
1 289 GLY n 
1 290 THR n 
1 291 LEU n 
1 292 THR n 
1 293 PRO n 
1 294 LEU n 
1 295 SER n 
1 296 THR n 
1 297 LYS n 
1 298 ASP n 
1 299 LEU n 
1 300 THR n 
1 301 THR n 
1 302 TYR n 
2 1   MET n 
2 2   GLY n 
2 3   ALA n 
2 4   GLN n 
2 5   VAL n 
2 6   SER n 
2 7   SER n 
2 8   GLN n 
2 9   LYS n 
2 10  VAL n 
2 11  GLY n 
2 12  ALA n 
2 13  HIS n 
2 14  GLU n 
2 15  ASN n 
2 16  SER n 
2 17  ASN n 
2 18  GLY n 
2 19  ALA n 
2 20  TYR n 
2 21  GLY n 
2 22  GLY n 
2 23  SER n 
2 24  THR n 
2 25  ILE n 
2 26  ASN n 
2 27  TYR n 
2 28  THR n 
2 29  THR n 
2 30  ILE n 
2 31  ASN n 
2 32  TYR n 
2 33  TYR n 
2 34  ARG n 
2 35  ASP n 
2 36  SER n 
2 37  ALA n 
2 38  SER n 
2 39  ASN n 
2 40  ALA n 
2 41  ALA n 
2 42  SER n 
2 43  LYS n 
2 44  GLN n 
2 45  ASP n 
2 46  PHE n 
2 47  SER n 
2 48  GLN n 
2 49  ASP n 
2 50  PRO n 
2 51  SER n 
2 52  LYS n 
2 53  PHE n 
2 54  THR n 
2 55  GLU n 
2 56  PRO n 
2 57  ILE n 
2 58  LYS n 
2 59  ASP n 
2 60  VAL n 
2 61  LEU n 
2 62  ILE n 
2 63  LYS n 
2 64  THR n 
2 65  ALA n 
2 66  PRO n 
2 67  MET n 
2 68  LEU n 
2 69  ASN n 
2 70  SER n 
2 71  PRO n 
2 72  ASN n 
2 73  ILE n 
2 74  GLU n 
2 75  ALA n 
2 76  CYS n 
2 77  GLY n 
2 78  TYR n 
2 79  SER n 
2 80  ASP n 
2 81  ARG n 
2 82  VAL n 
2 83  LEU n 
2 84  GLN n 
2 85  LEU n 
2 86  THR n 
2 87  LEU n 
2 88  GLY n 
2 89  ASN n 
2 90  SER n 
2 91  THR n 
2 92  ILE n 
2 93  THR n 
2 94  ALA n 
2 95  GLN n 
2 96  GLU n 
2 97  ALA n 
2 98  ALA n 
2 99  ASN n 
2 100 SER n 
2 101 VAL n 
2 102 VAL n 
2 103 ALA n 
2 104 TYR n 
2 105 GLY n 
2 106 ARG n 
2 107 TRP n 
2 108 PRO n 
2 109 GLU n 
2 110 TYR n 
2 111 LEU n 
2 112 ARG n 
2 113 ASP n 
2 114 SER n 
2 115 GLU n 
2 116 ALA n 
2 117 ASN n 
2 118 PRO n 
2 119 VAL n 
2 120 ASP n 
2 121 GLN n 
2 122 PRO n 
2 123 THR n 
2 124 GLU n 
2 125 PRO n 
2 126 GLU n 
2 127 VAL n 
2 128 ALA n 
2 129 ALA n 
2 130 CYS n 
2 131 ARG n 
2 132 PHE n 
2 133 TYR n 
2 134 THR n 
2 135 LEU n 
2 136 ASP n 
2 137 THR n 
2 138 VAL n 
2 139 SER n 
2 140 TRP n 
2 141 THR n 
2 142 LYS n 
2 143 GLU n 
2 144 SER n 
2 145 ARG n 
2 146 GLY n 
2 147 TRP n 
2 148 TRP n 
2 149 TRP n 
2 150 LYS n 
2 151 LEU n 
2 152 PRO n 
2 153 ASP n 
2 154 ALA n 
2 155 LEU n 
2 156 ARG n 
2 157 ASP n 
2 158 MET n 
2 159 GLY n 
2 160 LEU n 
2 161 PHE n 
2 162 GLY n 
2 163 GLN n 
2 164 ASN n 
2 165 MET n 
2 166 TYR n 
2 167 TYR n 
2 168 HIS n 
2 169 TYR n 
2 170 LEU n 
2 171 GLY n 
2 172 ARG n 
2 173 SER n 
2 174 GLY n 
2 175 TYR n 
2 176 THR n 
2 177 VAL n 
2 178 HIS n 
2 179 VAL n 
2 180 GLN n 
2 181 CYS n 
2 182 ASN n 
2 183 ALA n 
2 184 SER n 
2 185 LYS n 
2 186 PHE n 
2 187 HIS n 
2 188 GLN n 
2 189 GLY n 
2 190 ALA n 
2 191 LEU n 
2 192 GLY n 
2 193 VAL n 
2 194 PHE n 
2 195 ALA n 
2 196 VAL n 
2 197 PRO n 
2 198 GLU n 
2 199 MET n 
2 200 CYS n 
2 201 LEU n 
2 202 ALA n 
2 203 GLY n 
2 204 ASP n 
2 205 SER n 
2 206 ASN n 
2 207 THR n 
2 208 THR n 
2 209 THR n 
2 210 MET n 
2 211 HIS n 
2 212 THR n 
2 213 SER n 
2 214 TYR n 
2 215 GLN n 
2 216 ASN n 
2 217 ALA n 
2 218 ASN n 
2 219 PRO n 
2 220 GLY n 
2 221 GLU n 
2 222 LYS n 
2 223 GLY n 
2 224 GLY n 
2 225 THR n 
2 226 PHE n 
2 227 THR n 
2 228 GLY n 
2 229 THR n 
2 230 PHE n 
2 231 THR n 
2 232 PRO n 
2 233 ASP n 
2 234 ASN n 
2 235 ASN n 
2 236 GLN n 
2 237 THR n 
2 238 SER n 
2 239 PRO n 
2 240 ALA n 
2 241 ARG n 
2 242 ARG n 
2 243 PHE n 
2 244 CYS n 
2 245 PRO n 
2 246 VAL n 
2 247 ASP n 
2 248 TYR n 
2 249 LEU n 
2 250 LEU n 
2 251 GLY n 
2 252 ASN n 
2 253 GLY n 
2 254 THR n 
2 255 LEU n 
2 256 LEU n 
2 257 GLY n 
2 258 ASN n 
2 259 ALA n 
2 260 PHE n 
2 261 VAL n 
2 262 PHE n 
2 263 PRO n 
2 264 HIS n 
2 265 GLN n 
2 266 ILE n 
2 267 ILE n 
2 268 ASN n 
2 269 LEU n 
2 270 ARG n 
2 271 THR n 
2 272 ASN n 
2 273 ASN n 
2 274 CYS n 
2 275 ALA n 
2 276 THR n 
2 277 LEU n 
2 278 VAL n 
2 279 LEU n 
2 280 PRO n 
2 281 TYR n 
2 282 VAL n 
2 283 ASN n 
2 284 SER n 
2 285 LEU n 
2 286 SER n 
2 287 ILE n 
2 288 ASP n 
2 289 SER n 
2 290 MET n 
2 291 VAL n 
2 292 LYS n 
2 293 HIS n 
2 294 ASN n 
2 295 ASN n 
2 296 TRP n 
2 297 GLY n 
2 298 ILE n 
2 299 ALA n 
2 300 ILE n 
2 301 LEU n 
2 302 PRO n 
2 303 LEU n 
2 304 ALA n 
2 305 PRO n 
2 306 LEU n 
2 307 ASN n 
2 308 PHE n 
2 309 ALA n 
2 310 SER n 
2 311 GLU n 
2 312 SER n 
2 313 SER n 
2 314 PRO n 
2 315 GLU n 
2 316 ILE n 
2 317 PRO n 
2 318 ILE n 
2 319 THR n 
2 320 LEU n 
2 321 THR n 
2 322 ILE n 
2 323 ALA n 
2 324 PRO n 
2 325 MET n 
2 326 CYS n 
2 327 CYS n 
2 328 GLU n 
2 329 PHE n 
2 330 ASN n 
2 331 GLY n 
2 332 LEU n 
2 333 ARG n 
2 334 ASN n 
2 335 ILE n 
2 336 THR n 
2 337 LEU n 
2 338 PRO n 
2 339 ARG n 
2 340 LEU n 
2 341 GLN n 
3 1   GLY n 
3 2   LEU n 
3 3   PRO n 
3 4   VAL n 
3 5   MET n 
3 6   ASN n 
3 7   THR n 
3 8   PRO n 
3 9   GLY n 
3 10  SER n 
3 11  ASN n 
3 12  GLN n 
3 13  TYR n 
3 14  LEU n 
3 15  THR n 
3 16  ALA n 
3 17  ASP n 
3 18  ASN n 
3 19  PHE n 
3 20  GLN n 
3 21  SER n 
3 22  PRO n 
3 23  CYS n 
3 24  ALA n 
3 25  LEU n 
3 26  PRO n 
3 27  GLU n 
3 28  PHE n 
3 29  ASP n 
3 30  VAL n 
3 31  THR n 
3 32  PRO n 
3 33  PRO n 
3 34  ILE n 
3 35  ASP n 
3 36  ILE n 
3 37  PRO n 
3 38  GLY n 
3 39  GLU n 
3 40  VAL n 
3 41  LYS n 
3 42  ASN n 
3 43  MET n 
3 44  MET n 
3 45  GLU n 
3 46  LEU n 
3 47  ALA n 
3 48  GLU n 
3 49  ILE n 
3 50  ASP n 
3 51  THR n 
3 52  MET n 
3 53  ILE n 
3 54  PRO n 
3 55  PHE n 
3 56  ASP n 
3 57  LEU n 
3 58  SER n 
3 59  ALA n 
3 60  THR n 
3 61  LYS n 
3 62  LYS n 
3 63  ASN n 
3 64  THR n 
3 65  MET n 
3 66  GLU n 
3 67  MET n 
3 68  TYR n 
3 69  ARG n 
3 70  VAL n 
3 71  ARG n 
3 72  LEU n 
3 73  SER n 
3 74  ASP n 
3 75  LYS n 
3 76  PRO n 
3 77  HIS n 
3 78  THR n 
3 79  ASP n 
3 80  ASP n 
3 81  PRO n 
3 82  ILE n 
3 83  LEU n 
3 84  CYS n 
3 85  LEU n 
3 86  SER n 
3 87  LEU n 
3 88  SER n 
3 89  PRO n 
3 90  ALA n 
3 91  SER n 
3 92  ASP n 
3 93  PRO n 
3 94  ARG n 
3 95  LEU n 
3 96  SER n 
3 97  HIS n 
3 98  THR n 
3 99  MET n 
3 100 LEU n 
3 101 GLY n 
3 102 GLU n 
3 103 ILE n 
3 104 LEU n 
3 105 ASN n 
3 106 TYR n 
3 107 TYR n 
3 108 THR n 
3 109 HIS n 
3 110 TRP n 
3 111 ALA n 
3 112 GLY n 
3 113 SER n 
3 114 LEU n 
3 115 LYS n 
3 116 PHE n 
3 117 THR n 
3 118 PHE n 
3 119 MET n 
3 120 PHE n 
3 121 CYS n 
3 122 GLY n 
3 123 SER n 
3 124 MET n 
3 125 MET n 
3 126 ALA n 
3 127 THR n 
3 128 GLY n 
3 129 LYS n 
3 130 LEU n 
3 131 LEU n 
3 132 VAL n 
3 133 SER n 
3 134 TYR n 
3 135 ALA n 
3 136 PRO n 
3 137 PRO n 
3 138 GLY n 
3 139 ALA n 
3 140 ASP n 
3 141 PRO n 
3 142 PRO n 
3 143 LYS n 
3 144 LYS n 
3 145 ARG n 
3 146 LYS n 
3 147 GLU n 
3 148 ALA n 
3 149 MET n 
3 150 LEU n 
3 151 GLY n 
3 152 THR n 
3 153 HIS n 
3 154 VAL n 
3 155 ILE n 
3 156 TRP n 
3 157 ASP n 
3 158 ILE n 
3 159 GLY n 
3 160 LEU n 
3 161 GLN n 
3 162 SER n 
3 163 SER n 
3 164 CYS n 
3 165 THR n 
3 166 MET n 
3 167 VAL n 
3 168 VAL n 
3 169 PRO n 
3 170 TRP n 
3 171 ILE n 
3 172 SER n 
3 173 ASN n 
3 174 THR n 
3 175 THR n 
3 176 TYR n 
3 177 ARG n 
3 178 LEU n 
3 179 THR n 
3 180 ILE n 
3 181 ASP n 
3 182 ASP n 
3 183 SER n 
3 184 PHE n 
3 185 THR n 
3 186 GLU n 
3 187 GLY n 
3 188 GLY n 
3 189 TYR n 
3 190 ILE n 
3 191 SER n 
3 192 VAL n 
3 193 PHE n 
3 194 TYR n 
3 195 GLN n 
3 196 THR n 
3 197 ARG n 
3 198 ILE n 
3 199 VAL n 
3 200 VAL n 
3 201 PRO n 
3 202 LEU n 
3 203 SER n 
3 204 THR n 
3 205 PRO n 
3 206 ARG n 
3 207 GLU n 
3 208 MET n 
3 209 ASP n 
3 210 ILE n 
3 211 LEU n 
3 212 GLY n 
3 213 PHE n 
3 214 VAL n 
3 215 SER n 
3 216 ALA n 
3 217 CYS n 
3 218 ASN n 
3 219 ASP n 
3 220 PHE n 
3 221 SER n 
3 222 VAL n 
3 223 ARG n 
3 224 LEU n 
3 225 LEU n 
3 226 ARG n 
3 227 ASP n 
3 228 THR n 
3 229 THR n 
3 230 HIS n 
3 231 ILE n 
3 232 GLU n 
3 233 GLN n 
3 234 LYS n 
3 235 ALA n 
3 236 LEU n 
3 237 ALA n 
3 238 GLN n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 302 ? ? ? ? ? ? ? ? ? 'Human poliovirus 1 Mahoney' 12081 ? ? ? ? ? ? ? ? 
'Komagataella pastoris' 4922 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 341 ? ? ? ? ? ? ? ? ? 'Human poliovirus 1 Mahoney' 12081 ? ? ? ? ? ? ? ? 
'Komagataella pastoris' 4922 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 238 ? ? ? ? ? ? ? ? ? 'Human poliovirus 1 Mahoney' 12081 ? ? ? ? ? ? ? ? 
'Komagataella pastoris' 4922 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   1   ?   ?   ?   A . n 
A 1 2   LEU 2   2   ?   ?   ?   A . n 
A 1 3   GLY 3   3   ?   ?   ?   A . n 
A 1 4   GLN 4   4   ?   ?   ?   A . n 
A 1 5   MET 5   5   ?   ?   ?   A . n 
A 1 6   LEU 6   6   ?   ?   ?   A . n 
A 1 7   GLU 7   7   ?   ?   ?   A . n 
A 1 8   SER 8   8   ?   ?   ?   A . n 
A 1 9   MET 9   9   ?   ?   ?   A . n 
A 1 10  ILE 10  10  ?   ?   ?   A . n 
A 1 11  ASP 11  11  ?   ?   ?   A . n 
A 1 12  ASN 12  12  ?   ?   ?   A . n 
A 1 13  THR 13  13  ?   ?   ?   A . n 
A 1 14  VAL 14  14  ?   ?   ?   A . n 
A 1 15  ARG 15  15  ?   ?   ?   A . n 
A 1 16  GLU 16  16  ?   ?   ?   A . n 
A 1 17  THR 17  17  ?   ?   ?   A . n 
A 1 18  VAL 18  18  ?   ?   ?   A . n 
A 1 19  GLY 19  19  ?   ?   ?   A . n 
A 1 20  ALA 20  20  ?   ?   ?   A . n 
A 1 21  ALA 21  21  ?   ?   ?   A . n 
A 1 22  THR 22  22  ?   ?   ?   A . n 
A 1 23  SER 23  23  ?   ?   ?   A . n 
A 1 24  ARG 24  24  ?   ?   ?   A . n 
A 1 25  ASP 25  25  ?   ?   ?   A . n 
A 1 26  ALA 26  26  ?   ?   ?   A . n 
A 1 27  LEU 27  27  ?   ?   ?   A . n 
A 1 28  PRO 28  28  ?   ?   ?   A . n 
A 1 29  ASN 29  29  ?   ?   ?   A . n 
A 1 30  THR 30  30  ?   ?   ?   A . n 
A 1 31  GLU 31  31  ?   ?   ?   A . n 
A 1 32  ALA 32  32  ?   ?   ?   A . n 
A 1 33  SER 33  33  ?   ?   ?   A . n 
A 1 34  GLY 34  34  ?   ?   ?   A . n 
A 1 35  PRO 35  35  ?   ?   ?   A . n 
A 1 36  THR 36  36  ?   ?   ?   A . n 
A 1 37  HIS 37  37  ?   ?   ?   A . n 
A 1 38  SER 38  38  ?   ?   ?   A . n 
A 1 39  LYS 39  39  ?   ?   ?   A . n 
A 1 40  GLU 40  40  ?   ?   ?   A . n 
A 1 41  ILE 41  41  ?   ?   ?   A . n 
A 1 42  PRO 42  42  ?   ?   ?   A . n 
A 1 43  ALA 43  43  ?   ?   ?   A . n 
A 1 44  LEU 44  44  ?   ?   ?   A . n 
A 1 45  THR 45  45  ?   ?   ?   A . n 
A 1 46  ALA 46  46  ?   ?   ?   A . n 
A 1 47  VAL 47  47  ?   ?   ?   A . n 
A 1 48  GLU 48  48  ?   ?   ?   A . n 
A 1 49  THR 49  49  ?   ?   ?   A . n 
A 1 50  GLY 50  50  ?   ?   ?   A . n 
A 1 51  ALA 51  51  ?   ?   ?   A . n 
A 1 52  THR 52  52  ?   ?   ?   A . n 
A 1 53  ASN 53  53  ?   ?   ?   A . n 
A 1 54  PRO 54  54  ?   ?   ?   A . n 
A 1 55  LEU 55  55  ?   ?   ?   A . n 
A 1 56  VAL 56  56  ?   ?   ?   A . n 
A 1 57  PRO 57  57  ?   ?   ?   A . n 
A 1 58  SER 58  58  ?   ?   ?   A . n 
A 1 59  ASP 59  59  ?   ?   ?   A . n 
A 1 60  THR 60  60  ?   ?   ?   A . n 
A 1 61  VAL 61  61  ?   ?   ?   A . n 
A 1 62  GLN 62  62  ?   ?   ?   A . n 
A 1 63  THR 63  63  ?   ?   ?   A . n 
A 1 64  ARG 64  64  ?   ?   ?   A . n 
A 1 65  HIS 65  65  ?   ?   ?   A . n 
A 1 66  VAL 66  66  ?   ?   ?   A . n 
A 1 67  VAL 67  67  ?   ?   ?   A . n 
A 1 68  GLN 68  68  ?   ?   ?   A . n 
A 1 69  HIS 69  69  69  HIS HIS A . n 
A 1 70  ARG 70  70  70  ARG ARG A . n 
A 1 71  SER 71  71  71  SER SER A . n 
A 1 72  ARG 72  72  72  ARG ARG A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  GLU 74  74  74  GLU GLU A . n 
A 1 75  SER 75  75  75  SER SER A . n 
A 1 76  SER 76  76  76  SER SER A . n 
A 1 77  ILE 77  77  77  ILE ILE A . n 
A 1 78  GLU 78  78  78  GLU GLU A . n 
A 1 79  SER 79  79  79  SER SER A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  ARG 83  83  83  ARG ARG A . n 
A 1 84  GLY 84  84  84  GLY GLY A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  CYS 86  86  86  CYS CYS A . n 
A 1 87  VAL 87  87  87  VAL VAL A . n 
A 1 88  THR 88  88  88  THR THR A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  MET 90  90  90  MET MET A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  PRO 95  95  95  PRO PRO A . n 
A 1 96  ALA 96  96  96  ALA ALA A . n 
A 1 97  SER 97  97  97  SER SER A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  THR 99  99  99  THR THR A . n 
A 1 100 ASN 100 100 100 ASN ASN A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 ASP 102 102 102 ASP ASP A . n 
A 1 103 LYS 103 103 103 LYS LYS A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 PHE 105 105 105 PHE PHE A . n 
A 1 106 ALA 106 106 106 ALA ALA A . n 
A 1 107 VAL 107 107 107 VAL VAL A . n 
A 1 108 TRP 108 108 108 TRP TRP A . n 
A 1 109 LYS 109 109 109 LYS LYS A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 TYR 112 112 112 TYR TYR A . n 
A 1 113 LYS 113 113 113 LYS LYS A . n 
A 1 114 ASP 114 114 114 ASP ASP A . n 
A 1 115 THR 115 115 115 THR THR A . n 
A 1 116 VAL 116 116 116 VAL VAL A . n 
A 1 117 GLN 117 117 117 GLN GLN A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 ARG 119 119 119 ARG ARG A . n 
A 1 120 ARG 120 120 120 ARG ARG A . n 
A 1 121 LYS 121 121 121 LYS LYS A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 PHE 124 124 124 PHE PHE A . n 
A 1 125 PHE 125 125 125 PHE PHE A . n 
A 1 126 THR 126 126 126 THR THR A . n 
A 1 127 TYR 127 127 127 TYR TYR A . n 
A 1 128 SER 128 128 128 SER SER A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 PHE 130 130 130 PHE PHE A . n 
A 1 131 ASP 131 131 131 ASP ASP A . n 
A 1 132 MET 132 132 132 MET MET A . n 
A 1 133 GLU 133 133 133 GLU GLU A . n 
A 1 134 LEU 134 134 134 LEU LEU A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 PHE 136 136 136 PHE PHE A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 VAL 138 138 138 VAL VAL A . n 
A 1 139 THR 139 139 139 THR THR A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 ASN 141 141 141 ASN ASN A . n 
A 1 142 PHE 142 142 142 PHE PHE A . n 
A 1 143 THR 143 143 143 THR THR A . n 
A 1 144 GLU 144 144 144 GLU GLU A . n 
A 1 145 THR 145 145 145 THR THR A . n 
A 1 146 ASN 146 146 146 ASN ASN A . n 
A 1 147 ASN 147 147 147 ASN ASN A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 HIS 149 149 149 HIS HIS A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 ASN 152 152 152 ASN ASN A . n 
A 1 153 GLN 153 153 153 GLN GLN A . n 
A 1 154 VAL 154 154 154 VAL VAL A . n 
A 1 155 TYR 155 155 155 TYR TYR A . n 
A 1 156 GLN 156 156 156 GLN GLN A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 MET 158 158 158 MET MET A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 PRO 161 161 161 PRO PRO A . n 
A 1 162 PRO 162 162 162 PRO PRO A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 PRO 165 165 165 PRO PRO A . n 
A 1 166 VAL 166 166 166 VAL VAL A . n 
A 1 167 PRO 167 167 167 PRO PRO A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 LYS 169 169 169 LYS LYS A . n 
A 1 170 TRP 170 170 170 TRP TRP A . n 
A 1 171 ASP 171 171 171 ASP ASP A . n 
A 1 172 ASP 172 172 172 ASP ASP A . n 
A 1 173 TYR 173 173 173 TYR TYR A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 TRP 175 175 175 TRP TRP A . n 
A 1 176 GLN 176 176 176 GLN GLN A . n 
A 1 177 THR 177 177 177 THR THR A . n 
A 1 178 SER 178 178 178 SER SER A . n 
A 1 179 SER 179 179 179 SER SER A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PRO 181 181 181 PRO PRO A . n 
A 1 182 SER 182 182 182 SER SER A . n 
A 1 183 ILE 183 183 183 ILE ILE A . n 
A 1 184 PHE 184 184 184 PHE PHE A . n 
A 1 185 TYR 185 185 185 TYR TYR A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 TYR 187 187 187 TYR TYR A . n 
A 1 188 GLY 188 188 188 GLY GLY A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 PRO 191 191 191 PRO PRO A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 ARG 193 193 193 ARG ARG A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 PRO 197 197 197 PRO PRO A . n 
A 1 198 TYR 198 198 198 TYR TYR A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
A 1 200 GLY 200 200 200 GLY GLY A . n 
A 1 201 ILE 201 201 201 ILE ILE A . n 
A 1 202 SER 202 202 202 SER SER A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 TYR 205 205 205 TYR TYR A . n 
A 1 206 SER 206 206 206 SER SER A . n 
A 1 207 HIS 207 207 207 HIS HIS A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ASP 210 210 210 ASP ASP A . n 
A 1 211 GLY 211 211 211 GLY GLY A . n 
A 1 212 PHE 212 212 212 PHE PHE A . n 
A 1 213 SER 213 213 213 SER SER A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 VAL 215 215 ?   ?   ?   A . n 
A 1 216 PRO 216 216 ?   ?   ?   A . n 
A 1 217 LEU 217 217 ?   ?   ?   A . n 
A 1 218 LYS 218 218 ?   ?   ?   A . n 
A 1 219 ASP 219 219 ?   ?   ?   A . n 
A 1 220 GLN 220 220 ?   ?   ?   A . n 
A 1 221 SER 221 221 ?   ?   ?   A . n 
A 1 222 ALA 222 222 ?   ?   ?   A . n 
A 1 223 ALA 223 223 ?   ?   ?   A . n 
A 1 224 LEU 224 224 ?   ?   ?   A . n 
A 1 225 GLY 225 225 ?   ?   ?   A . n 
A 1 226 ASP 226 226 ?   ?   ?   A . n 
A 1 227 SER 227 227 ?   ?   ?   A . n 
A 1 228 LEU 228 228 ?   ?   ?   A . n 
A 1 229 TYR 229 229 ?   ?   ?   A . n 
A 1 230 GLY 230 230 ?   ?   ?   A . n 
A 1 231 ALA 231 231 ?   ?   ?   A . n 
A 1 232 ALA 232 232 ?   ?   ?   A . n 
A 1 233 SER 233 233 233 SER SER A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ASN 235 235 235 ASN ASN A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 PHE 237 237 237 PHE PHE A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 ILE 239 239 239 ILE ILE A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 VAL 242 242 242 VAL VAL A . n 
A 1 243 ARG 243 243 243 ARG ARG A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 VAL 245 245 245 VAL VAL A . n 
A 1 246 ASN 246 246 246 ASN ASN A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 PRO 248 248 248 PRO PRO A . n 
A 1 249 ASN 249 249 249 ASN ASN A . n 
A 1 250 PRO 250 250 250 PRO PRO A . n 
A 1 251 THR 251 251 251 THR THR A . n 
A 1 252 LYS 252 252 252 LYS LYS A . n 
A 1 253 VAL 253 253 253 VAL VAL A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 LYS 256 256 256 LYS LYS A . n 
A 1 257 ILE 257 257 257 ILE ILE A . n 
A 1 258 ARG 258 258 258 ARG ARG A . n 
A 1 259 VAL 259 259 259 VAL VAL A . n 
A 1 260 TYR 260 260 260 TYR TYR A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 LYS 262 262 262 LYS LYS A . n 
A 1 263 PRO 263 263 263 PRO PRO A . n 
A 1 264 LYS 264 264 264 LYS LYS A . n 
A 1 265 HIS 265 265 265 HIS HIS A . n 
A 1 266 ILE 266 266 266 ILE ILE A . n 
A 1 267 ARG 267 267 267 ARG ARG A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 TRP 269 269 269 TRP TRP A . n 
A 1 270 CYS 270 270 270 CYS CYS A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 ARG 272 272 272 ARG ARG A . n 
A 1 273 PRO 273 273 273 PRO PRO A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 ARG 275 275 275 ARG ARG A . n 
A 1 276 ALA 276 276 276 ALA ALA A . n 
A 1 277 VAL 277 277 277 VAL VAL A . n 
A 1 278 ALA 278 278 278 ALA ALA A . n 
A 1 279 TYR 279 279 279 TYR TYR A . n 
A 1 280 TYR 280 280 280 TYR TYR A . n 
A 1 281 GLY 281 281 ?   ?   ?   A . n 
A 1 282 PRO 282 282 ?   ?   ?   A . n 
A 1 283 GLY 283 283 ?   ?   ?   A . n 
A 1 284 VAL 284 284 ?   ?   ?   A . n 
A 1 285 ASP 285 285 ?   ?   ?   A . n 
A 1 286 TYR 286 286 ?   ?   ?   A . n 
A 1 287 LYS 287 287 ?   ?   ?   A . n 
A 1 288 ASP 288 288 ?   ?   ?   A . n 
A 1 289 GLY 289 289 ?   ?   ?   A . n 
A 1 290 THR 290 290 ?   ?   ?   A . n 
A 1 291 LEU 291 291 ?   ?   ?   A . n 
A 1 292 THR 292 292 ?   ?   ?   A . n 
A 1 293 PRO 293 293 ?   ?   ?   A . n 
A 1 294 LEU 294 294 ?   ?   ?   A . n 
A 1 295 SER 295 295 ?   ?   ?   A . n 
A 1 296 THR 296 296 ?   ?   ?   A . n 
A 1 297 LYS 297 297 ?   ?   ?   A . n 
A 1 298 ASP 298 298 ?   ?   ?   A . n 
A 1 299 LEU 299 299 ?   ?   ?   A . n 
A 1 300 THR 300 300 ?   ?   ?   A . n 
A 1 301 THR 301 301 ?   ?   ?   A . n 
A 1 302 TYR 302 302 ?   ?   ?   A . n 
B 2 1   MET 1   1   ?   ?   ?   B . n 
B 2 2   GLY 2   2   ?   ?   ?   B . n 
B 2 3   ALA 3   3   ?   ?   ?   B . n 
B 2 4   GLN 4   4   ?   ?   ?   B . n 
B 2 5   VAL 5   5   ?   ?   ?   B . n 
B 2 6   SER 6   6   ?   ?   ?   B . n 
B 2 7   SER 7   7   ?   ?   ?   B . n 
B 2 8   GLN 8   8   ?   ?   ?   B . n 
B 2 9   LYS 9   9   ?   ?   ?   B . n 
B 2 10  VAL 10  10  ?   ?   ?   B . n 
B 2 11  GLY 11  11  ?   ?   ?   B . n 
B 2 12  ALA 12  12  ?   ?   ?   B . n 
B 2 13  HIS 13  13  ?   ?   ?   B . n 
B 2 14  GLU 14  14  ?   ?   ?   B . n 
B 2 15  ASN 15  15  ?   ?   ?   B . n 
B 2 16  SER 16  16  ?   ?   ?   B . n 
B 2 17  ASN 17  17  ?   ?   ?   B . n 
B 2 18  GLY 18  18  ?   ?   ?   B . n 
B 2 19  ALA 19  19  ?   ?   ?   B . n 
B 2 20  TYR 20  20  ?   ?   ?   B . n 
B 2 21  GLY 21  21  ?   ?   ?   B . n 
B 2 22  GLY 22  22  ?   ?   ?   B . n 
B 2 23  SER 23  23  ?   ?   ?   B . n 
B 2 24  THR 24  24  ?   ?   ?   B . n 
B 2 25  ILE 25  25  ?   ?   ?   B . n 
B 2 26  ASN 26  26  ?   ?   ?   B . n 
B 2 27  TYR 27  27  ?   ?   ?   B . n 
B 2 28  THR 28  28  ?   ?   ?   B . n 
B 2 29  THR 29  29  ?   ?   ?   B . n 
B 2 30  ILE 30  30  ?   ?   ?   B . n 
B 2 31  ASN 31  31  ?   ?   ?   B . n 
B 2 32  TYR 32  32  ?   ?   ?   B . n 
B 2 33  TYR 33  33  ?   ?   ?   B . n 
B 2 34  ARG 34  34  ?   ?   ?   B . n 
B 2 35  ASP 35  35  ?   ?   ?   B . n 
B 2 36  SER 36  36  ?   ?   ?   B . n 
B 2 37  ALA 37  37  ?   ?   ?   B . n 
B 2 38  SER 38  38  ?   ?   ?   B . n 
B 2 39  ASN 39  39  ?   ?   ?   B . n 
B 2 40  ALA 40  40  ?   ?   ?   B . n 
B 2 41  ALA 41  41  ?   ?   ?   B . n 
B 2 42  SER 42  42  ?   ?   ?   B . n 
B 2 43  LYS 43  43  ?   ?   ?   B . n 
B 2 44  GLN 44  44  ?   ?   ?   B . n 
B 2 45  ASP 45  45  ?   ?   ?   B . n 
B 2 46  PHE 46  46  ?   ?   ?   B . n 
B 2 47  SER 47  47  ?   ?   ?   B . n 
B 2 48  GLN 48  48  ?   ?   ?   B . n 
B 2 49  ASP 49  49  ?   ?   ?   B . n 
B 2 50  PRO 50  50  ?   ?   ?   B . n 
B 2 51  SER 51  51  ?   ?   ?   B . n 
B 2 52  LYS 52  52  ?   ?   ?   B . n 
B 2 53  PHE 53  53  ?   ?   ?   B . n 
B 2 54  THR 54  54  ?   ?   ?   B . n 
B 2 55  GLU 55  55  ?   ?   ?   B . n 
B 2 56  PRO 56  56  ?   ?   ?   B . n 
B 2 57  ILE 57  57  ?   ?   ?   B . n 
B 2 58  LYS 58  58  ?   ?   ?   B . n 
B 2 59  ASP 59  59  ?   ?   ?   B . n 
B 2 60  VAL 60  60  ?   ?   ?   B . n 
B 2 61  LEU 61  61  ?   ?   ?   B . n 
B 2 62  ILE 62  62  ?   ?   ?   B . n 
B 2 63  LYS 63  63  ?   ?   ?   B . n 
B 2 64  THR 64  64  ?   ?   ?   B . n 
B 2 65  ALA 65  65  ?   ?   ?   B . n 
B 2 66  PRO 66  66  ?   ?   ?   B . n 
B 2 67  MET 67  67  ?   ?   ?   B . n 
B 2 68  LEU 68  68  ?   ?   ?   B . n 
B 2 69  ASN 69  69  ?   ?   ?   B . n 
B 2 70  SER 70  70  ?   ?   ?   B . n 
B 2 71  PRO 71  71  ?   ?   ?   B . n 
B 2 72  ASN 72  72  ?   ?   ?   B . n 
B 2 73  ILE 73  73  ?   ?   ?   B . n 
B 2 74  GLU 74  74  ?   ?   ?   B . n 
B 2 75  ALA 75  75  ?   ?   ?   B . n 
B 2 76  CYS 76  76  ?   ?   ?   B . n 
B 2 77  GLY 77  77  ?   ?   ?   B . n 
B 2 78  TYR 78  78  ?   ?   ?   B . n 
B 2 79  SER 79  79  ?   ?   ?   B . n 
B 2 80  ASP 80  80  ?   ?   ?   B . n 
B 2 81  ARG 81  81  ?   ?   ?   B . n 
B 2 82  VAL 82  82  ?   ?   ?   B . n 
B 2 83  LEU 83  83  ?   ?   ?   B . n 
B 2 84  GLN 84  84  84  GLN GLN B . n 
B 2 85  LEU 85  85  85  LEU LEU B . n 
B 2 86  THR 86  86  86  THR THR B . n 
B 2 87  LEU 87  87  87  LEU LEU B . n 
B 2 88  GLY 88  88  88  GLY GLY B . n 
B 2 89  ASN 89  89  89  ASN ASN B . n 
B 2 90  SER 90  90  90  SER SER B . n 
B 2 91  THR 91  91  91  THR THR B . n 
B 2 92  ILE 92  92  92  ILE ILE B . n 
B 2 93  THR 93  93  93  THR THR B . n 
B 2 94  ALA 94  94  94  ALA ALA B . n 
B 2 95  GLN 95  95  95  GLN GLN B . n 
B 2 96  GLU 96  96  ?   ?   ?   B . n 
B 2 97  ALA 97  97  ?   ?   ?   B . n 
B 2 98  ALA 98  98  98  ALA ALA B . n 
B 2 99  ASN 99  99  99  ASN ASN B . n 
B 2 100 SER 100 100 100 SER SER B . n 
B 2 101 VAL 101 101 101 VAL VAL B . n 
B 2 102 VAL 102 102 102 VAL VAL B . n 
B 2 103 ALA 103 103 103 ALA ALA B . n 
B 2 104 TYR 104 104 104 TYR TYR B . n 
B 2 105 GLY 105 105 105 GLY GLY B . n 
B 2 106 ARG 106 106 106 ARG ARG B . n 
B 2 107 TRP 107 107 107 TRP TRP B . n 
B 2 108 PRO 108 108 108 PRO PRO B . n 
B 2 109 GLU 109 109 109 GLU GLU B . n 
B 2 110 TYR 110 110 110 TYR TYR B . n 
B 2 111 LEU 111 111 111 LEU LEU B . n 
B 2 112 ARG 112 112 112 ARG ARG B . n 
B 2 113 ASP 113 113 ?   ?   ?   B . n 
B 2 114 SER 114 114 ?   ?   ?   B . n 
B 2 115 GLU 115 115 ?   ?   ?   B . n 
B 2 116 ALA 116 116 ?   ?   ?   B . n 
B 2 117 ASN 117 117 ?   ?   ?   B . n 
B 2 118 PRO 118 118 ?   ?   ?   B . n 
B 2 119 VAL 119 119 ?   ?   ?   B . n 
B 2 120 ASP 120 120 ?   ?   ?   B . n 
B 2 121 GLN 121 121 ?   ?   ?   B . n 
B 2 122 PRO 122 122 122 PRO PRO B . n 
B 2 123 THR 123 123 123 THR THR B . n 
B 2 124 GLU 124 124 124 GLU GLU B . n 
B 2 125 PRO 125 125 125 PRO PRO B . n 
B 2 126 GLU 126 126 126 GLU GLU B . n 
B 2 127 VAL 127 127 127 VAL VAL B . n 
B 2 128 ALA 128 128 128 ALA ALA B . n 
B 2 129 ALA 129 129 129 ALA ALA B . n 
B 2 130 CYS 130 130 130 CYS CYS B . n 
B 2 131 ARG 131 131 131 ARG ARG B . n 
B 2 132 PHE 132 132 132 PHE PHE B . n 
B 2 133 TYR 133 133 133 TYR TYR B . n 
B 2 134 THR 134 134 134 THR THR B . n 
B 2 135 LEU 135 135 135 LEU LEU B . n 
B 2 136 ASP 136 136 136 ASP ASP B . n 
B 2 137 THR 137 137 137 THR THR B . n 
B 2 138 VAL 138 138 138 VAL VAL B . n 
B 2 139 SER 139 139 139 SER SER B . n 
B 2 140 TRP 140 140 140 TRP TRP B . n 
B 2 141 THR 141 141 141 THR THR B . n 
B 2 142 LYS 142 142 142 LYS LYS B . n 
B 2 143 GLU 143 143 143 GLU GLU B . n 
B 2 144 SER 144 144 144 SER SER B . n 
B 2 145 ARG 145 145 145 ARG ARG B . n 
B 2 146 GLY 146 146 146 GLY GLY B . n 
B 2 147 TRP 147 147 147 TRP TRP B . n 
B 2 148 TRP 148 148 148 TRP TRP B . n 
B 2 149 TRP 149 149 149 TRP TRP B . n 
B 2 150 LYS 150 150 150 LYS LYS B . n 
B 2 151 LEU 151 151 151 LEU LEU B . n 
B 2 152 PRO 152 152 152 PRO PRO B . n 
B 2 153 ASP 153 153 153 ASP ASP B . n 
B 2 154 ALA 154 154 154 ALA ALA B . n 
B 2 155 LEU 155 155 155 LEU LEU B . n 
B 2 156 ARG 156 156 156 ARG ARG B . n 
B 2 157 ASP 157 157 157 ASP ASP B . n 
B 2 158 MET 158 158 158 MET MET B . n 
B 2 159 GLY 159 159 159 GLY GLY B . n 
B 2 160 LEU 160 160 160 LEU LEU B . n 
B 2 161 PHE 161 161 161 PHE PHE B . n 
B 2 162 GLY 162 162 162 GLY GLY B . n 
B 2 163 GLN 163 163 163 GLN GLN B . n 
B 2 164 ASN 164 164 164 ASN ASN B . n 
B 2 165 MET 165 165 165 MET MET B . n 
B 2 166 TYR 166 166 166 TYR TYR B . n 
B 2 167 TYR 167 167 167 TYR TYR B . n 
B 2 168 HIS 168 168 168 HIS HIS B . n 
B 2 169 TYR 169 169 169 TYR TYR B . n 
B 2 170 LEU 170 170 170 LEU LEU B . n 
B 2 171 GLY 171 171 171 GLY GLY B . n 
B 2 172 ARG 172 172 172 ARG ARG B . n 
B 2 173 SER 173 173 173 SER SER B . n 
B 2 174 GLY 174 174 174 GLY GLY B . n 
B 2 175 TYR 175 175 175 TYR TYR B . n 
B 2 176 THR 176 176 176 THR THR B . n 
B 2 177 VAL 177 177 177 VAL VAL B . n 
B 2 178 HIS 178 178 178 HIS HIS B . n 
B 2 179 VAL 179 179 179 VAL VAL B . n 
B 2 180 GLN 180 180 180 GLN GLN B . n 
B 2 181 CYS 181 181 181 CYS CYS B . n 
B 2 182 ASN 182 182 182 ASN ASN B . n 
B 2 183 ALA 183 183 183 ALA ALA B . n 
B 2 184 SER 184 184 184 SER SER B . n 
B 2 185 LYS 185 185 185 LYS LYS B . n 
B 2 186 PHE 186 186 186 PHE PHE B . n 
B 2 187 HIS 187 187 187 HIS HIS B . n 
B 2 188 GLN 188 188 188 GLN GLN B . n 
B 2 189 GLY 189 189 189 GLY GLY B . n 
B 2 190 ALA 190 190 190 ALA ALA B . n 
B 2 191 LEU 191 191 191 LEU LEU B . n 
B 2 192 GLY 192 192 192 GLY GLY B . n 
B 2 193 VAL 193 193 193 VAL VAL B . n 
B 2 194 PHE 194 194 194 PHE PHE B . n 
B 2 195 ALA 195 195 195 ALA ALA B . n 
B 2 196 VAL 196 196 196 VAL VAL B . n 
B 2 197 PRO 197 197 197 PRO PRO B . n 
B 2 198 GLU 198 198 198 GLU GLU B . n 
B 2 199 MET 199 199 199 MET MET B . n 
B 2 200 CYS 200 200 200 CYS CYS B . n 
B 2 201 LEU 201 201 201 LEU LEU B . n 
B 2 202 ALA 202 202 202 ALA ALA B . n 
B 2 203 GLY 203 203 203 GLY GLY B . n 
B 2 204 ASP 204 204 ?   ?   ?   B . n 
B 2 205 SER 205 205 ?   ?   ?   B . n 
B 2 206 ASN 206 206 ?   ?   ?   B . n 
B 2 207 THR 207 207 ?   ?   ?   B . n 
B 2 208 THR 208 208 ?   ?   ?   B . n 
B 2 209 THR 209 209 ?   ?   ?   B . n 
B 2 210 MET 210 210 ?   ?   ?   B . n 
B 2 211 HIS 211 211 ?   ?   ?   B . n 
B 2 212 THR 212 212 212 THR THR B . n 
B 2 213 SER 213 213 213 SER SER B . n 
B 2 214 TYR 214 214 214 TYR TYR B . n 
B 2 215 GLN 215 215 215 GLN GLN B . n 
B 2 216 ASN 216 216 216 ASN ASN B . n 
B 2 217 ALA 217 217 217 ALA ALA B . n 
B 2 218 ASN 218 218 218 ASN ASN B . n 
B 2 219 PRO 219 219 219 PRO PRO B . n 
B 2 220 GLY 220 220 220 GLY GLY B . n 
B 2 221 GLU 221 221 221 GLU GLU B . n 
B 2 222 LYS 222 222 222 LYS LYS B . n 
B 2 223 GLY 223 223 223 GLY GLY B . n 
B 2 224 GLY 224 224 224 GLY GLY B . n 
B 2 225 THR 225 225 225 THR THR B . n 
B 2 226 PHE 226 226 226 PHE PHE B . n 
B 2 227 THR 227 227 227 THR THR B . n 
B 2 228 GLY 228 228 228 GLY GLY B . n 
B 2 229 THR 229 229 ?   ?   ?   B . n 
B 2 230 PHE 230 230 ?   ?   ?   B . n 
B 2 231 THR 231 231 ?   ?   ?   B . n 
B 2 232 PRO 232 232 ?   ?   ?   B . n 
B 2 233 ASP 233 233 ?   ?   ?   B . n 
B 2 234 ASN 234 234 ?   ?   ?   B . n 
B 2 235 ASN 235 235 ?   ?   ?   B . n 
B 2 236 GLN 236 236 ?   ?   ?   B . n 
B 2 237 THR 237 237 ?   ?   ?   B . n 
B 2 238 SER 238 238 ?   ?   ?   B . n 
B 2 239 PRO 239 239 ?   ?   ?   B . n 
B 2 240 ALA 240 240 ?   ?   ?   B . n 
B 2 241 ARG 241 241 ?   ?   ?   B . n 
B 2 242 ARG 242 242 ?   ?   ?   B . n 
B 2 243 PHE 243 243 243 PHE PHE B . n 
B 2 244 CYS 244 244 244 CYS CYS B . n 
B 2 245 PRO 245 245 245 PRO PRO B . n 
B 2 246 VAL 246 246 246 VAL VAL B . n 
B 2 247 ASP 247 247 247 ASP ASP B . n 
B 2 248 TYR 248 248 248 TYR TYR B . n 
B 2 249 LEU 249 249 249 LEU LEU B . n 
B 2 250 LEU 250 250 250 LEU LEU B . n 
B 2 251 GLY 251 251 251 GLY GLY B . n 
B 2 252 ASN 252 252 252 ASN ASN B . n 
B 2 253 GLY 253 253 253 GLY GLY B . n 
B 2 254 THR 254 254 254 THR THR B . n 
B 2 255 LEU 255 255 255 LEU LEU B . n 
B 2 256 LEU 256 256 256 LEU LEU B . n 
B 2 257 GLY 257 257 257 GLY GLY B . n 
B 2 258 ASN 258 258 258 ASN ASN B . n 
B 2 259 ALA 259 259 259 ALA ALA B . n 
B 2 260 PHE 260 260 260 PHE PHE B . n 
B 2 261 VAL 261 261 261 VAL VAL B . n 
B 2 262 PHE 262 262 262 PHE PHE B . n 
B 2 263 PRO 263 263 263 PRO PRO B . n 
B 2 264 HIS 264 264 264 HIS HIS B . n 
B 2 265 GLN 265 265 265 GLN GLN B . n 
B 2 266 ILE 266 266 266 ILE ILE B . n 
B 2 267 ILE 267 267 267 ILE ILE B . n 
B 2 268 ASN 268 268 268 ASN ASN B . n 
B 2 269 LEU 269 269 269 LEU LEU B . n 
B 2 270 ARG 270 270 270 ARG ARG B . n 
B 2 271 THR 271 271 271 THR THR B . n 
B 2 272 ASN 272 272 272 ASN ASN B . n 
B 2 273 ASN 273 273 273 ASN ASN B . n 
B 2 274 CYS 274 274 274 CYS CYS B . n 
B 2 275 ALA 275 275 275 ALA ALA B . n 
B 2 276 THR 276 276 276 THR THR B . n 
B 2 277 LEU 277 277 277 LEU LEU B . n 
B 2 278 VAL 278 278 278 VAL VAL B . n 
B 2 279 LEU 279 279 279 LEU LEU B . n 
B 2 280 PRO 280 280 280 PRO PRO B . n 
B 2 281 TYR 281 281 281 TYR TYR B . n 
B 2 282 VAL 282 282 282 VAL VAL B . n 
B 2 283 ASN 283 283 283 ASN ASN B . n 
B 2 284 SER 284 284 284 SER SER B . n 
B 2 285 LEU 285 285 285 LEU LEU B . n 
B 2 286 SER 286 286 286 SER SER B . n 
B 2 287 ILE 287 287 287 ILE ILE B . n 
B 2 288 ASP 288 288 288 ASP ASP B . n 
B 2 289 SER 289 289 289 SER SER B . n 
B 2 290 MET 290 290 290 MET MET B . n 
B 2 291 VAL 291 291 291 VAL VAL B . n 
B 2 292 LYS 292 292 292 LYS LYS B . n 
B 2 293 HIS 293 293 293 HIS HIS B . n 
B 2 294 ASN 294 294 294 ASN ASN B . n 
B 2 295 ASN 295 295 295 ASN ASN B . n 
B 2 296 TRP 296 296 296 TRP TRP B . n 
B 2 297 GLY 297 297 297 GLY GLY B . n 
B 2 298 ILE 298 298 298 ILE ILE B . n 
B 2 299 ALA 299 299 299 ALA ALA B . n 
B 2 300 ILE 300 300 300 ILE ILE B . n 
B 2 301 LEU 301 301 301 LEU LEU B . n 
B 2 302 PRO 302 302 302 PRO PRO B . n 
B 2 303 LEU 303 303 303 LEU LEU B . n 
B 2 304 ALA 304 304 304 ALA ALA B . n 
B 2 305 PRO 305 305 305 PRO PRO B . n 
B 2 306 LEU 306 306 306 LEU LEU B . n 
B 2 307 ASN 307 307 307 ASN ASN B . n 
B 2 308 PHE 308 308 308 PHE PHE B . n 
B 2 309 ALA 309 309 309 ALA ALA B . n 
B 2 310 SER 310 310 310 SER SER B . n 
B 2 311 GLU 311 311 311 GLU GLU B . n 
B 2 312 SER 312 312 312 SER SER B . n 
B 2 313 SER 313 313 313 SER SER B . n 
B 2 314 PRO 314 314 314 PRO PRO B . n 
B 2 315 GLU 315 315 315 GLU GLU B . n 
B 2 316 ILE 316 316 316 ILE ILE B . n 
B 2 317 PRO 317 317 317 PRO PRO B . n 
B 2 318 ILE 318 318 318 ILE ILE B . n 
B 2 319 THR 319 319 319 THR THR B . n 
B 2 320 LEU 320 320 320 LEU LEU B . n 
B 2 321 THR 321 321 321 THR THR B . n 
B 2 322 ILE 322 322 322 ILE ILE B . n 
B 2 323 ALA 323 323 323 ALA ALA B . n 
B 2 324 PRO 324 324 324 PRO PRO B . n 
B 2 325 MET 325 325 325 MET MET B . n 
B 2 326 CYS 326 326 326 CYS CYS B . n 
B 2 327 CYS 327 327 327 CYS CYS B . n 
B 2 328 GLU 328 328 328 GLU GLU B . n 
B 2 329 PHE 329 329 329 PHE PHE B . n 
B 2 330 ASN 330 330 330 ASN ASN B . n 
B 2 331 GLY 331 331 331 GLY GLY B . n 
B 2 332 LEU 332 332 332 LEU LEU B . n 
B 2 333 ARG 333 333 333 ARG ARG B . n 
B 2 334 ASN 334 334 334 ASN ASN B . n 
B 2 335 ILE 335 335 335 ILE ILE B . n 
B 2 336 THR 336 336 ?   ?   ?   B . n 
B 2 337 LEU 337 337 ?   ?   ?   B . n 
B 2 338 PRO 338 338 ?   ?   ?   B . n 
B 2 339 ARG 339 339 ?   ?   ?   B . n 
B 2 340 LEU 340 340 ?   ?   ?   B . n 
B 2 341 GLN 341 341 ?   ?   ?   B . n 
C 3 1   GLY 1   1   1   GLY GLY C . n 
C 3 2   LEU 2   2   2   LEU LEU C . n 
C 3 3   PRO 3   3   3   PRO PRO C . n 
C 3 4   VAL 4   4   4   VAL VAL C . n 
C 3 5   MET 5   5   5   MET MET C . n 
C 3 6   ASN 6   6   6   ASN ASN C . n 
C 3 7   THR 7   7   7   THR THR C . n 
C 3 8   PRO 8   8   8   PRO PRO C . n 
C 3 9   GLY 9   9   9   GLY GLY C . n 
C 3 10  SER 10  10  10  SER SER C . n 
C 3 11  ASN 11  11  11  ASN ASN C . n 
C 3 12  GLN 12  12  12  GLN GLN C . n 
C 3 13  TYR 13  13  13  TYR TYR C . n 
C 3 14  LEU 14  14  14  LEU LEU C . n 
C 3 15  THR 15  15  15  THR THR C . n 
C 3 16  ALA 16  16  16  ALA ALA C . n 
C 3 17  ASP 17  17  17  ASP ASP C . n 
C 3 18  ASN 18  18  18  ASN ASN C . n 
C 3 19  PHE 19  19  19  PHE PHE C . n 
C 3 20  GLN 20  20  20  GLN GLN C . n 
C 3 21  SER 21  21  21  SER SER C . n 
C 3 22  PRO 22  22  22  PRO PRO C . n 
C 3 23  CYS 23  23  23  CYS CYS C . n 
C 3 24  ALA 24  24  24  ALA ALA C . n 
C 3 25  LEU 25  25  25  LEU LEU C . n 
C 3 26  PRO 26  26  26  PRO PRO C . n 
C 3 27  GLU 27  27  27  GLU GLU C . n 
C 3 28  PHE 28  28  28  PHE PHE C . n 
C 3 29  ASP 29  29  29  ASP ASP C . n 
C 3 30  VAL 30  30  30  VAL VAL C . n 
C 3 31  THR 31  31  31  THR THR C . n 
C 3 32  PRO 32  32  32  PRO PRO C . n 
C 3 33  PRO 33  33  33  PRO PRO C . n 
C 3 34  ILE 34  34  34  ILE ILE C . n 
C 3 35  ASP 35  35  35  ASP ASP C . n 
C 3 36  ILE 36  36  36  ILE ILE C . n 
C 3 37  PRO 37  37  37  PRO PRO C . n 
C 3 38  GLY 38  38  38  GLY GLY C . n 
C 3 39  GLU 39  39  39  GLU GLU C . n 
C 3 40  VAL 40  40  40  VAL VAL C . n 
C 3 41  LYS 41  41  41  LYS LYS C . n 
C 3 42  ASN 42  42  42  ASN ASN C . n 
C 3 43  MET 43  43  43  MET MET C . n 
C 3 44  MET 44  44  44  MET MET C . n 
C 3 45  GLU 45  45  45  GLU GLU C . n 
C 3 46  LEU 46  46  46  LEU LEU C . n 
C 3 47  ALA 47  47  47  ALA ALA C . n 
C 3 48  GLU 48  48  48  GLU GLU C . n 
C 3 49  ILE 49  49  49  ILE ILE C . n 
C 3 50  ASP 50  50  50  ASP ASP C . n 
C 3 51  THR 51  51  51  THR THR C . n 
C 3 52  MET 52  52  52  MET MET C . n 
C 3 53  ILE 53  53  53  ILE ILE C . n 
C 3 54  PRO 54  54  54  PRO PRO C . n 
C 3 55  PHE 55  55  55  PHE PHE C . n 
C 3 56  ASP 56  56  56  ASP ASP C . n 
C 3 57  LEU 57  57  57  LEU LEU C . n 
C 3 58  SER 58  58  58  SER SER C . n 
C 3 59  ALA 59  59  59  ALA ALA C . n 
C 3 60  THR 60  60  60  THR THR C . n 
C 3 61  LYS 61  61  61  LYS LYS C . n 
C 3 62  LYS 62  62  62  LYS LYS C . n 
C 3 63  ASN 63  63  63  ASN ASN C . n 
C 3 64  THR 64  64  64  THR THR C . n 
C 3 65  MET 65  65  65  MET MET C . n 
C 3 66  GLU 66  66  66  GLU GLU C . n 
C 3 67  MET 67  67  67  MET MET C . n 
C 3 68  TYR 68  68  68  TYR TYR C . n 
C 3 69  ARG 69  69  69  ARG ARG C . n 
C 3 70  VAL 70  70  70  VAL VAL C . n 
C 3 71  ARG 71  71  71  ARG ARG C . n 
C 3 72  LEU 72  72  72  LEU LEU C . n 
C 3 73  SER 73  73  73  SER SER C . n 
C 3 74  ASP 74  74  74  ASP ASP C . n 
C 3 75  LYS 75  75  75  LYS LYS C . n 
C 3 76  PRO 76  76  76  PRO PRO C . n 
C 3 77  HIS 77  77  77  HIS HIS C . n 
C 3 78  THR 78  78  78  THR THR C . n 
C 3 79  ASP 79  79  79  ASP ASP C . n 
C 3 80  ASP 80  80  80  ASP ASP C . n 
C 3 81  PRO 81  81  81  PRO PRO C . n 
C 3 82  ILE 82  82  82  ILE ILE C . n 
C 3 83  LEU 83  83  83  LEU LEU C . n 
C 3 84  CYS 84  84  84  CYS CYS C . n 
C 3 85  LEU 85  85  85  LEU LEU C . n 
C 3 86  SER 86  86  86  SER SER C . n 
C 3 87  LEU 87  87  87  LEU LEU C . n 
C 3 88  SER 88  88  88  SER SER C . n 
C 3 89  PRO 89  89  89  PRO PRO C . n 
C 3 90  ALA 90  90  90  ALA ALA C . n 
C 3 91  SER 91  91  91  SER SER C . n 
C 3 92  ASP 92  92  92  ASP ASP C . n 
C 3 93  PRO 93  93  93  PRO PRO C . n 
C 3 94  ARG 94  94  94  ARG ARG C . n 
C 3 95  LEU 95  95  95  LEU LEU C . n 
C 3 96  SER 96  96  96  SER SER C . n 
C 3 97  HIS 97  97  97  HIS HIS C . n 
C 3 98  THR 98  98  98  THR THR C . n 
C 3 99  MET 99  99  99  MET MET C . n 
C 3 100 LEU 100 100 100 LEU LEU C . n 
C 3 101 GLY 101 101 101 GLY GLY C . n 
C 3 102 GLU 102 102 102 GLU GLU C . n 
C 3 103 ILE 103 103 103 ILE ILE C . n 
C 3 104 LEU 104 104 104 LEU LEU C . n 
C 3 105 ASN 105 105 105 ASN ASN C . n 
C 3 106 TYR 106 106 106 TYR TYR C . n 
C 3 107 TYR 107 107 107 TYR TYR C . n 
C 3 108 THR 108 108 108 THR THR C . n 
C 3 109 HIS 109 109 109 HIS HIS C . n 
C 3 110 TRP 110 110 110 TRP TRP C . n 
C 3 111 ALA 111 111 111 ALA ALA C . n 
C 3 112 GLY 112 112 112 GLY GLY C . n 
C 3 113 SER 113 113 113 SER SER C . n 
C 3 114 LEU 114 114 114 LEU LEU C . n 
C 3 115 LYS 115 115 115 LYS LYS C . n 
C 3 116 PHE 116 116 116 PHE PHE C . n 
C 3 117 THR 117 117 117 THR THR C . n 
C 3 118 PHE 118 118 118 PHE PHE C . n 
C 3 119 MET 119 119 119 MET MET C . n 
C 3 120 PHE 120 120 120 PHE PHE C . n 
C 3 121 CYS 121 121 121 CYS CYS C . n 
C 3 122 GLY 122 122 122 GLY GLY C . n 
C 3 123 SER 123 123 123 SER SER C . n 
C 3 124 MET 124 124 124 MET MET C . n 
C 3 125 MET 125 125 125 MET MET C . n 
C 3 126 ALA 126 126 126 ALA ALA C . n 
C 3 127 THR 127 127 127 THR THR C . n 
C 3 128 GLY 128 128 128 GLY GLY C . n 
C 3 129 LYS 129 129 129 LYS LYS C . n 
C 3 130 LEU 130 130 130 LEU LEU C . n 
C 3 131 LEU 131 131 131 LEU LEU C . n 
C 3 132 VAL 132 132 132 VAL VAL C . n 
C 3 133 SER 133 133 133 SER SER C . n 
C 3 134 TYR 134 134 134 TYR TYR C . n 
C 3 135 ALA 135 135 135 ALA ALA C . n 
C 3 136 PRO 136 136 136 PRO PRO C . n 
C 3 137 PRO 137 137 137 PRO PRO C . n 
C 3 138 GLY 138 138 138 GLY GLY C . n 
C 3 139 ALA 139 139 139 ALA ALA C . n 
C 3 140 ASP 140 140 140 ASP ASP C . n 
C 3 141 PRO 141 141 141 PRO PRO C . n 
C 3 142 PRO 142 142 142 PRO PRO C . n 
C 3 143 LYS 143 143 143 LYS LYS C . n 
C 3 144 LYS 144 144 144 LYS LYS C . n 
C 3 145 ARG 145 145 145 ARG ARG C . n 
C 3 146 LYS 146 146 146 LYS LYS C . n 
C 3 147 GLU 147 147 147 GLU GLU C . n 
C 3 148 ALA 148 148 148 ALA ALA C . n 
C 3 149 MET 149 149 149 MET MET C . n 
C 3 150 LEU 150 150 150 LEU LEU C . n 
C 3 151 GLY 151 151 151 GLY GLY C . n 
C 3 152 THR 152 152 152 THR THR C . n 
C 3 153 HIS 153 153 153 HIS HIS C . n 
C 3 154 VAL 154 154 154 VAL VAL C . n 
C 3 155 ILE 155 155 155 ILE ILE C . n 
C 3 156 TRP 156 156 156 TRP TRP C . n 
C 3 157 ASP 157 157 157 ASP ASP C . n 
C 3 158 ILE 158 158 158 ILE ILE C . n 
C 3 159 GLY 159 159 159 GLY GLY C . n 
C 3 160 LEU 160 160 160 LEU LEU C . n 
C 3 161 GLN 161 161 161 GLN GLN C . n 
C 3 162 SER 162 162 162 SER SER C . n 
C 3 163 SER 163 163 163 SER SER C . n 
C 3 164 CYS 164 164 164 CYS CYS C . n 
C 3 165 THR 165 165 165 THR THR C . n 
C 3 166 MET 166 166 166 MET MET C . n 
C 3 167 VAL 167 167 167 VAL VAL C . n 
C 3 168 VAL 168 168 168 VAL VAL C . n 
C 3 169 PRO 169 169 169 PRO PRO C . n 
C 3 170 TRP 170 170 170 TRP TRP C . n 
C 3 171 ILE 171 171 171 ILE ILE C . n 
C 3 172 SER 172 172 172 SER SER C . n 
C 3 173 ASN 173 173 173 ASN ASN C . n 
C 3 174 THR 174 174 174 THR THR C . n 
C 3 175 THR 175 175 175 THR THR C . n 
C 3 176 TYR 176 176 176 TYR TYR C . n 
C 3 177 ARG 177 177 177 ARG ARG C . n 
C 3 178 LEU 178 178 178 LEU LEU C . n 
C 3 179 THR 179 179 179 THR THR C . n 
C 3 180 ILE 180 180 180 ILE ILE C . n 
C 3 181 ASP 181 181 181 ASP ASP C . n 
C 3 182 ASP 182 182 182 ASP ASP C . n 
C 3 183 SER 183 183 183 SER SER C . n 
C 3 184 PHE 184 184 184 PHE PHE C . n 
C 3 185 THR 185 185 185 THR THR C . n 
C 3 186 GLU 186 186 186 GLU GLU C . n 
C 3 187 GLY 187 187 187 GLY GLY C . n 
C 3 188 GLY 188 188 188 GLY GLY C . n 
C 3 189 TYR 189 189 189 TYR TYR C . n 
C 3 190 ILE 190 190 190 ILE ILE C . n 
C 3 191 SER 191 191 191 SER SER C . n 
C 3 192 VAL 192 192 192 VAL VAL C . n 
C 3 193 PHE 193 193 193 PHE PHE C . n 
C 3 194 TYR 194 194 194 TYR TYR C . n 
C 3 195 GLN 195 195 195 GLN GLN C . n 
C 3 196 THR 196 196 196 THR THR C . n 
C 3 197 ARG 197 197 197 ARG ARG C . n 
C 3 198 ILE 198 198 198 ILE ILE C . n 
C 3 199 VAL 199 199 199 VAL VAL C . n 
C 3 200 VAL 200 200 200 VAL VAL C . n 
C 3 201 PRO 201 201 201 PRO PRO C . n 
C 3 202 LEU 202 202 202 LEU LEU C . n 
C 3 203 SER 203 203 203 SER SER C . n 
C 3 204 THR 204 204 204 THR THR C . n 
C 3 205 PRO 205 205 205 PRO PRO C . n 
C 3 206 ARG 206 206 206 ARG ARG C . n 
C 3 207 GLU 207 207 207 GLU GLU C . n 
C 3 208 MET 208 208 208 MET MET C . n 
C 3 209 ASP 209 209 209 ASP ASP C . n 
C 3 210 ILE 210 210 210 ILE ILE C . n 
C 3 211 LEU 211 211 211 LEU LEU C . n 
C 3 212 GLY 212 212 212 GLY GLY C . n 
C 3 213 PHE 213 213 213 PHE PHE C . n 
C 3 214 VAL 214 214 214 VAL VAL C . n 
C 3 215 SER 215 215 215 SER SER C . n 
C 3 216 ALA 216 216 216 ALA ALA C . n 
C 3 217 CYS 217 217 217 CYS CYS C . n 
C 3 218 ASN 218 218 218 ASN ASN C . n 
C 3 219 ASP 219 219 219 ASP ASP C . n 
C 3 220 PHE 220 220 220 PHE PHE C . n 
C 3 221 SER 221 221 221 SER SER C . n 
C 3 222 VAL 222 222 222 VAL VAL C . n 
C 3 223 ARG 223 223 223 ARG ARG C . n 
C 3 224 LEU 224 224 224 LEU LEU C . n 
C 3 225 LEU 225 225 225 LEU LEU C . n 
C 3 226 ARG 226 226 226 ARG ARG C . n 
C 3 227 ASP 227 227 227 ASP ASP C . n 
C 3 228 THR 228 228 228 THR THR C . n 
C 3 229 THR 229 229 229 THR THR C . n 
C 3 230 HIS 230 230 230 HIS HIS C . n 
C 3 231 ILE 231 231 231 ILE ILE C . n 
C 3 232 GLU 232 232 232 GLU GLU C . n 
C 3 233 GLN 233 233 ?   ?   ?   C . n 
C 3 234 LYS 234 234 ?   ?   ?   C . n 
C 3 235 ALA 235 235 ?   ?   ?   C . n 
C 3 236 LEU 236 236 ?   ?   ?   C . n 
C 3 237 ALA 237 237 ?   ?   ?   C . n 
C 3 238 GLN 238 238 ?   ?   ?   C . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9EZ0 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9EZ0 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9EZ0 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9EZ0 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            . 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.004  ? 31392 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.508  ? 42780 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 10.887 ? 11298 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.042  ? 4746  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004  ? 5448  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9EZ0 
_struct.title                        
'Poliovirus type 1 (strain Mahoney) expanded conformation stabilised virus-like particle (PV1 SC6b) from a yeast expression system.' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9EZ0 
_struct_keywords.text            'Capsid protein, virus-like particle, vaccine, VIRUS LIKE PARTICLE' 
_struct_keywords.pdbx_keywords   'VIRUS LIKE PARTICLE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP POLG_POL1M P03300 ? 1 
;GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESF
FARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYV
PPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGIL
AVRVVNDHNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY
;
580 
2 UNP POLG_POL1M P03300 ? 2 
;GAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSDR
VLQLTLGNSTITTQEAANSVVAYGRWPEYLRDSEANPVDQPTEPDVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGLF
GQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPAR
RFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITLT
IAPMCCEFNGLRNITLPRLQ
;
2   
3 UNP POLG_POL1M P03300 ? 3 
;GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDD
PILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFLFCGFMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRQTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQ
;
342 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9EZ0 A 1 ? 302 ? P03300 580 ? 881 ? 1 302 
2 2 9EZ0 B 2 ? 341 ? P03300 2   ? 341 ? 2 341 
3 3 9EZ0 C 1 ? 238 ? P03300 342 ? 579 ? 1 238 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9EZ0 PRO A 248 ? UNP P03300 HIS 827 'engineered mutation'   248 1 
2 9EZ0 MET B 1   ? UNP P03300 ?   ?   'initiating methionine' 1   2 
2 9EZ0 GLY B 18  ? UNP P03300 ARG 18  'engineered mutation'   18  3 
2 9EZ0 ALA B 94  ? UNP P03300 THR 94  'engineered mutation'   94  4 
2 9EZ0 GLU B 126 ? UNP P03300 ASP 126 'engineered mutation'   126 5 
3 9EZ0 MET C 119 ? UNP P03300 LEU 460 'engineered mutation'   119 6 
3 9EZ0 SER C 123 ? UNP P03300 PHE 464 variant                 123 7 
3 9EZ0 LEU C 178 ? UNP P03300 GLN 519 'engineered mutation'   178 8 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   180-meric 
_pdbx_struct_assembly.oligomeric_count     180 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   
;1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60
;
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1  'identity operation'       1_555 x,y,z 1.000000  0.000000  0.000000  0.00000    0.000000  1.000000  0.000000  0.00000    
0.000000  0.000000  1.000000  0.00000    
2  'point symmetry operation' ?     ?     -0.809017 -0.500000 0.309017  419.75251  -0.500000 0.309017  -0.809017 419.67301  
0.309017  -0.809017 -0.500000 419.62387  
3  'point symmetry operation' ?     ?     0.000000  1.000000  0.000000  0.03050    0.000000  0.000000  -1.000000 419.65100  
-1.000000 0.000000  0.000000  419.68150  
4  'point symmetry operation' ?     ?     0.809017  -0.500000 -0.309017 209.83809  -0.500000 -0.309017 -0.809017 549.36324  
0.309017  0.809017  -0.500000 80.09045   
5  'point symmetry operation' ?     ?     0.500000  0.309017  -0.809017 209.82981  -0.309017 -0.809017 -0.500000 549.36835  
-0.809017 0.500000  -0.309017 339.51177  
6  'point symmetry operation' ?     ?     -0.309017 -0.809017 -0.500000 549.39885  -0.809017 0.500000  -0.309017 339.54717  
0.500000  0.309017  -0.809017 209.76391  
7  'point symmetry operation' ?     ?     -0.809017 0.500000  -0.309017 339.57767  0.500000  0.309017  -0.809017 209.79931  
-0.309017 -0.809017 -0.500000 549.33295  
8  'point symmetry operation' ?     ?     -0.809017 -0.500000 -0.309017 549.42087  0.500000  -0.309017 -0.809017 339.48954  
0.309017  -0.809017 0.500000  209.81607  
9  'point symmetry operation' ?     ?     -0.309017 0.809017  -0.500000 209.86543  -0.809017 -0.500000 -0.309017 549.39037  
-0.500000 0.309017  0.809017  80.16146   
10 'point symmetry operation' ?     ?     0.500000  -0.309017 -0.809017 339.52004  -0.309017 0.809017  -0.500000 209.83493  
0.809017  0.500000  0.309017  -129.73937 
11 'point symmetry operation' ?     ?     0.000000  0.000000  -1.000000 419.68150  -1.000000 0.000000  0.000000  419.71690  
0.000000  1.000000  0.000000  -0.03540   
12 'point symmetry operation' ?     ?     -0.500000 -0.309017 -0.809017 549.39374  0.309017  0.809017  -0.500000 80.12585   
0.809017  -0.500000 -0.309017 209.77219  
13 'point symmetry operation' ?     ?     -0.500000 0.309017  -0.809017 419.70351  0.309017  -0.809017 -0.500000 419.65927  
-0.809017 -0.500000 0.309017  419.68661  
14 'point symmetry operation' ?     ?     -0.309017 -0.809017 -0.500000 549.39885  0.809017  -0.500000 0.309017  80.13923   
-0.500000 -0.309017 0.809017  209.85169  
15 'point symmetry operation' ?     ?     -0.809017 0.500000  -0.309017 339.57767  -0.500000 -0.309017 0.809017  209.88709  
0.309017  0.809017  0.500000  -129.71735 
16 'point symmetry operation' ?     ?     0.500000  0.309017  -0.809017 209.82981  0.309017  0.809017  0.500000  -129.68195 
0.809017  -0.500000 0.309017  80.10383   
17 'point symmetry operation' ?     ?     -0.500000 0.309017  -0.809017 419.70351  -0.309017 0.809017  0.500000  0.02713    
0.809017  0.500000  -0.309017 -0.07101   
18 'point symmetry operation' ?     ?     0.000000  0.000000  -1.000000 419.68150  1.000000  0.000000  0.000000  -0.03050   
0.000000  -1.000000 0.000000  419.65100  
19 'point symmetry operation' ?     ?     -0.500000 -0.309017 -0.809017 549.39374  -0.309017 -0.809017 0.500000  339.56055  
-0.809017 0.500000  0.309017  209.84341  
20 'point symmetry operation' ?     ?     0.000000  -1.000000 0.000000  419.71690  0.000000  0.000000  1.000000  0.03540    
-1.000000 0.000000  0.000000  419.68150  
21 'point symmetry operation' ?     ?     -0.809017 0.500000  0.309017  209.90931  0.500000  0.309017  0.809017  -129.67684 
0.309017  0.809017  -0.500000 80.09045   
22 'point symmetry operation' ?     ?     0.809017  0.500000  -0.309017 -0.00511   0.500000  -0.309017 0.809017  0.01339    
0.309017  -0.809017 -0.500000 419.62387  
23 'point symmetry operation' ?     ?     -0.309017 0.809017  -0.500000 209.86543  0.809017  0.500000  0.309017  -129.70397 
0.500000  -0.309017 -0.809017 339.45414  
24 'point symmetry operation' ?     ?     0.500000  -0.309017 -0.809017 339.52004  0.309017  -0.809017 0.500000  209.85147  
-0.809017 -0.500000 -0.309017 549.35497  
25 'point symmetry operation' ?     ?     -0.809017 -0.500000 -0.309017 549.42087  -0.500000 0.309017  0.809017  80.19686   
-0.309017 0.809017  -0.500000 209.79953  
26 'point symmetry operation' ?     ?     -0.309017 -0.809017 0.500000  339.59105  -0.809017 0.500000  0.309017  209.87881  
-0.500000 -0.309017 -0.809017 549.32784  
27 'point symmetry operation' ?     ?     -0.309017 0.809017  0.500000  0.05763    0.809017  0.500000  -0.309017 -0.03561   
-0.500000 0.309017  -0.809017 419.63761  
28 'point symmetry operation' ?     ?     1.000000  0.000000  0.000000  0.00000    0.000000  -1.000000 0.000000  419.68640  
0.000000  0.000000  -1.000000 419.61560  
29 'point symmetry operation' ?     ?     0.309017  0.809017  -0.500000 80.15635   0.809017  -0.500000 -0.309017 209.80759  
-0.500000 -0.309017 -0.809017 549.32784  
30 'point symmetry operation' ?     ?     0.309017  -0.809017 -0.500000 419.68977  -0.809017 -0.500000 0.309017  419.72201  
-0.500000 0.309017  -0.809017 419.63761  
31 'point symmetry operation' ?     ?     -1.000000 0.000000  0.000000  419.74740  0.000000  1.000000  0.000000  0.00000    
0.000000  0.000000  -1.000000 419.61560  
32 'point symmetry operation' ?     ?     0.809017  0.500000  -0.309017 -0.00511   -0.500000 0.309017  -0.809017 419.67301  
-0.309017 0.809017  0.500000  -0.00827   
33 'point symmetry operation' ?     ?     0.000000  -1.000000 0.000000  419.71690  0.000000  0.000000  -1.000000 419.65100  
1.000000  0.000000  0.000000  -0.06590   
34 'point symmetry operation' ?     ?     -0.809017 0.500000  0.309017  209.90931  -0.500000 -0.309017 -0.809017 549.36324  
-0.309017 -0.809017 0.500000  339.52515  
35 'point symmetry operation' ?     ?     -0.500000 -0.309017 0.809017  209.91759  -0.309017 -0.809017 -0.500000 549.36835  
0.809017  -0.500000 0.309017  80.10383   
36 'point symmetry operation' ?     ?     0.309017  0.809017  0.500000  -129.65145 -0.809017 0.500000  -0.309017 339.54717  
-0.500000 -0.309017 0.809017  209.85169  
37 'point symmetry operation' ?     ?     0.809017  -0.500000 0.309017  80.16973   0.500000  0.309017  -0.809017 209.79931  
0.309017  0.809017  0.500000  -129.71735 
38 'point symmetry operation' ?     ?     0.809017  0.500000  0.309017  -129.67347 0.500000  -0.309017 -0.809017 339.48954  
-0.309017 0.809017  -0.500000 209.79953  
39 'point symmetry operation' ?     ?     0.309017  -0.809017 0.500000  209.88197  -0.809017 -0.500000 -0.309017 549.39037  
0.500000  -0.309017 -0.809017 339.45414  
40 'point symmetry operation' ?     ?     -0.500000 0.309017  0.809017  80.22736   -0.309017 0.809017  -0.500000 209.83493  
-0.809017 -0.500000 -0.309017 549.35497  
41 'point symmetry operation' ?     ?     0.000000  0.000000  1.000000  0.06590    -1.000000 0.000000  0.000000  419.71690  
0.000000  -1.000000 0.000000  419.65100  
42 'point symmetry operation' ?     ?     0.500000  0.309017  0.809017  -129.64634 0.309017  0.809017  -0.500000 80.12585   
-0.809017 0.500000  0.309017  209.84341  
43 'point symmetry operation' ?     ?     0.500000  -0.309017 0.809017  0.04389    0.309017  -0.809017 -0.500000 419.65927  
0.809017  0.500000  -0.309017 -0.07101   
44 'point symmetry operation' ?     ?     0.309017  0.809017  0.500000  -129.65145 0.809017  -0.500000 0.309017  80.13923   
0.500000  0.309017  -0.809017 209.76391  
45 'point symmetry operation' ?     ?     0.809017  -0.500000 0.309017  80.16973   -0.500000 -0.309017 0.809017  209.88709  
-0.309017 -0.809017 -0.500000 549.33295  
46 'point symmetry operation' ?     ?     -0.500000 -0.309017 0.809017  209.91759  0.309017  0.809017  0.500000  -129.68195 
-0.809017 0.500000  -0.309017 339.51177  
47 'point symmetry operation' ?     ?     0.500000  -0.309017 0.809017  0.04389    -0.309017 0.809017  0.500000  0.02713    
-0.809017 -0.500000 0.309017  419.68661  
48 'point symmetry operation' ?     ?     0.000000  0.000000  1.000000  0.06590    1.000000  0.000000  0.000000  -0.03050   
0.000000  1.000000  0.000000  -0.03540   
49 'point symmetry operation' ?     ?     0.500000  0.309017  0.809017  -129.64634 -0.309017 -0.809017 0.500000  339.56055  
0.809017  -0.500000 -0.309017 209.77219  
50 'point symmetry operation' ?     ?     0.000000  1.000000  0.000000  0.03050    0.000000  0.000000  1.000000  0.03540    
1.000000  0.000000  0.000000  -0.06590   
51 'point symmetry operation' ?     ?     0.809017  -0.500000 -0.309017 209.83809  0.500000  0.309017  0.809017  -129.67684 
-0.309017 -0.809017 0.500000  339.52515  
52 'point symmetry operation' ?     ?     -0.809017 -0.500000 0.309017  419.75251  0.500000  -0.309017 0.809017  0.01339    
-0.309017 0.809017  0.500000  -0.00827   
53 'point symmetry operation' ?     ?     0.309017  -0.809017 0.500000  209.88197  0.809017  0.500000  0.309017  -129.70397 
-0.500000 0.309017  0.809017  80.16146   
54 'point symmetry operation' ?     ?     -0.500000 0.309017  0.809017  80.22736   0.309017  -0.809017 0.500000  209.85147  
0.809017  0.500000  0.309017  -129.73937 
55 'point symmetry operation' ?     ?     0.809017  0.500000  0.309017  -129.67347 -0.500000 0.309017  0.809017  80.19686   
0.309017  -0.809017 0.500000  209.81607  
56 'point symmetry operation' ?     ?     0.309017  0.809017  -0.500000 80.15635   -0.809017 0.500000  0.309017  209.87881  
0.500000  0.309017  0.809017  -129.71224 
57 'point symmetry operation' ?     ?     0.309017  -0.809017 -0.500000 419.68977  0.809017  0.500000  -0.309017 -0.03561   
0.500000  -0.309017 0.809017  -0.02201   
58 'point symmetry operation' ?     ?     -1.000000 0.000000  0.000000  419.74740  0.000000  -1.000000 0.000000  419.68640  
0.000000  0.000000  1.000000  0.00000    
59 'point symmetry operation' ?     ?     -0.309017 -0.809017 0.500000  339.59105  0.809017  -0.500000 -0.309017 209.80759  
0.500000  0.309017  0.809017  -129.71224 
60 'point symmetry operation' ?     ?     -0.309017 0.809017  0.500000  0.05763    -0.809017 -0.500000 0.309017  419.72201  
0.500000  -0.309017 0.809017  -0.02201   
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 76  ? ALA A 82  ? SER A 76  ALA A 82  1 ? 7 
HELX_P HELX_P2  AA2 THR A 115 ? GLU A 123 ? THR A 115 GLU A 123 1 ? 9 
HELX_P HELX_P3  AA3 ASP A 172 ? THR A 177 ? ASP A 172 THR A 177 1 ? 6 
HELX_P HELX_P4  AA4 TYR B 104 ? ARG B 106 ? TYR B 104 ARG B 106 5 ? 3 
HELX_P HELX_P5  AA5 PRO B 152 ? ARG B 156 ? PRO B 152 ARG B 156 5 ? 5 
HELX_P HELX_P6  AA6 GLY B 159 ? TYR B 166 ? GLY B 159 TYR B 166 1 ? 8 
HELX_P HELX_P7  AA7 SER B 213 ? ASN B 218 ? SER B 213 ASN B 218 1 ? 6 
HELX_P HELX_P8  AA8 LEU B 255 ? PHE B 262 ? LEU B 255 PHE B 262 5 ? 8 
HELX_P HELX_P9  AA9 MET C 43  ? GLU C 48  ? MET C 43  GLU C 48  1 ? 6 
HELX_P HELX_P10 AB1 LYS C 144 ? GLY C 151 ? LYS C 144 GLY C 151 1 ? 8 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LEU 
_struct_mon_prot_cis.label_seq_id           151 
_struct_mon_prot_cis.label_asym_id          B 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LEU 
_struct_mon_prot_cis.auth_seq_id            151 
_struct_mon_prot_cis.auth_asym_id           B 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    152 
_struct_mon_prot_cis.pdbx_label_asym_id_2   B 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     152 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    B 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -1.41 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 5 ? 
AA5 ? 5 ? 
AA6 ? 4 ? 
AA7 ? 2 ? 
AA8 ? 3 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? parallel      
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 85  ? ASP A 93  ? ALA A 85  ASP A 93  
AA1 2 THR A 254 ? LEU A 261 ? THR A 254 LEU A 261 
AA1 3 THR A 135 ? ASN A 141 ? THR A 135 ASN A 141 
AA1 4 ALA A 192 ? ARG A 193 ? ALA A 192 ARG A 193 
AA2 1 ALA A 106 ? LYS A 109 ? ALA A 106 LYS A 109 
AA2 2 ILE A 239 ? VAL A 244 ? ILE A 239 VAL A 244 
AA2 3 VAL A 154 ? VAL A 160 ? VAL A 154 VAL A 160 
AA2 4 SER A 182 ? THR A 186 ? SER A 182 THR A 186 
AA3 1 TYR A 205 ? SER A 206 ? TYR A 205 SER A 206 
AA3 2 PHE A 125 ? ASP A 131 ? PHE A 125 ASP A 131 
AA3 3 LYS A 264 ? PRO A 271 ? LYS A 264 PRO A 271 
AA3 4 GLU C 39  ? VAL C 40  ? GLU C 39  VAL C 40  
AA4 1 VAL B 101 ? VAL B 102 ? VAL B 101 VAL B 102 
AA4 2 CYS B 274 ? VAL B 278 ? CYS B 274 VAL B 278 
AA4 3 HIS B 178 ? CYS B 181 ? HIS B 178 CYS B 181 
AA4 4 ILE B 316 ? ILE B 322 ? ILE B 316 ILE B 322 
AA4 5 TYR B 133 ? THR B 134 ? TYR B 133 THR B 134 
AA5 1 VAL B 101 ? VAL B 102 ? VAL B 101 VAL B 102 
AA5 2 CYS B 274 ? VAL B 278 ? CYS B 274 VAL B 278 
AA5 3 HIS B 178 ? CYS B 181 ? HIS B 178 CYS B 181 
AA5 4 ILE B 316 ? ILE B 322 ? ILE B 316 ILE B 322 
AA5 5 VAL B 138 ? TRP B 140 ? VAL B 138 TRP B 140 
AA6 1 TRP B 147 ? LEU B 151 ? TRP B 147 LEU B 151 
AA6 2 TRP B 296 ? PHE B 308 ? TRP B 296 PHE B 308 
AA6 3 HIS B 187 ? ALA B 195 ? HIS B 187 ALA B 195 
AA6 4 HIS B 264 ? ASN B 268 ? HIS B 264 ASN B 268 
AA7 1 LEU B 170 ? GLY B 174 ? LEU B 170 GLY B 174 
AA7 2 MET B 325 ? ASN B 330 ? MET B 325 ASN B 330 
AA8 1 THR C 51  ? MET C 52  ? THR C 51  MET C 52  
AA8 2 ASP C 209 ? ALA C 216 ? ASP C 209 ALA C 216 
AA8 3 ARG C 69  ? ARG C 71  ? ARG C 69  ARG C 71  
AA9 1 THR C 51  ? MET C 52  ? THR C 51  MET C 52  
AA9 2 ASP C 209 ? ALA C 216 ? ASP C 209 ALA C 216 
AA9 3 LEU C 114 ? CYS C 121 ? LEU C 114 CYS C 121 
AA9 4 SER C 163 ? MET C 166 ? SER C 163 MET C 166 
AB1 1 LEU C 83  ? SER C 86  ? LEU C 83  SER C 86  
AB1 2 TYR C 189 ? VAL C 199 ? TYR C 189 VAL C 199 
AB1 3 THR C 127 ? ALA C 135 ? THR C 127 ALA C 135 
AB1 4 THR C 152 ? TRP C 156 ? THR C 152 TRP C 156 
AB2 1 ARG C 177 ? LEU C 178 ? ARG C 177 LEU C 178 
AB2 2 HIS C 109 ? TRP C 110 ? HIS C 109 TRP C 110 
AB2 3 VAL C 222 ? ARG C 223 ? VAL C 222 ARG C 223 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 87  ? N VAL A 87  O VAL A 259 ? O VAL A 259 
AA1 2 3 O TYR A 260 ? O TYR A 260 N THR A 135 ? N THR A 135 
AA1 3 4 N PHE A 136 ? N PHE A 136 O ALA A 192 ? O ALA A 192 
AA2 1 2 N ALA A 106 ? N ALA A 106 O VAL A 242 ? O VAL A 242 
AA2 2 3 O ALA A 241 ? O ALA A 241 N MET A 158 ? N MET A 158 
AA2 3 4 N TYR A 155 ? N TYR A 155 O TYR A 185 ? O TYR A 185 
AA3 1 2 O TYR A 205 ? O TYR A 205 N SER A 128 ? N SER A 128 
AA3 2 3 N ASP A 131 ? N ASP A 131 O LYS A 264 ? O LYS A 264 
AA3 3 4 N VAL A 268 ? N VAL A 268 O VAL C 40  ? O VAL C 40  
AA4 1 2 N VAL B 101 ? N VAL B 101 O THR B 276 ? O THR B 276 
AA4 2 3 O ALA B 275 ? O ALA B 275 N VAL B 179 ? N VAL B 179 
AA4 3 4 N GLN B 180 ? N GLN B 180 O THR B 319 ? O THR B 319 
AA4 4 5 O ILE B 322 ? O ILE B 322 N TYR B 133 ? N TYR B 133 
AA5 1 2 N VAL B 101 ? N VAL B 101 O THR B 276 ? O THR B 276 
AA5 2 3 O ALA B 275 ? O ALA B 275 N VAL B 179 ? N VAL B 179 
AA5 3 4 N GLN B 180 ? N GLN B 180 O THR B 319 ? O THR B 319 
AA5 4 5 O ILE B 318 ? O ILE B 318 N VAL B 138 ? N VAL B 138 
AA6 1 2 N TRP B 147 ? N TRP B 147 O ILE B 300 ? O ILE B 300 
AA6 2 3 O ASN B 307 ? O ASN B 307 N GLN B 188 ? N GLN B 188 
AA6 3 4 N VAL B 193 ? N VAL B 193 O GLN B 265 ? O GLN B 265 
AA7 1 2 N LEU B 170 ? N LEU B 170 O ASN B 330 ? O ASN B 330 
AA8 1 2 O THR C 51  ? O THR C 51  N VAL C 214 ? N VAL C 214 
AA8 2 3 O ILE C 210 ? O ILE C 210 N VAL C 70  ? N VAL C 70  
AA9 1 2 O THR C 51  ? O THR C 51  N VAL C 214 ? N VAL C 214 
AA9 2 3 O LEU C 211 ? O LEU C 211 N MET C 119 ? N MET C 119 
AA9 3 4 N PHE C 116 ? N PHE C 116 O MET C 166 ? O MET C 166 
AB1 1 2 N LEU C 85  ? N LEU C 85  O ILE C 190 ? O ILE C 190 
AB1 2 3 O VAL C 199 ? O VAL C 199 N THR C 127 ? N THR C 127 
AB1 3 4 N VAL C 132 ? N VAL C 132 O VAL C 154 ? O VAL C 154 
AB2 1 2 O ARG C 177 ? O ARG C 177 N TRP C 110 ? N TRP C 110 
AB2 2 3 N HIS C 109 ? N HIS C 109 O ARG C 223 ? O ARG C 223 
# 
_pdbx_entry_details.entry_id                   9EZ0 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OG1 C THR 51  ? ? O   C THR 98  ? ? 2.07 
2 1 OH  A TYR 127 ? ? OE2 B GLU 198 ? ? 2.13 
3 1 NH1 A ARG 70  ? ? O   C ALA 111 ? ? 2.15 
4 1 O   C GLY 101 ? ? ND2 C ASN 105 ? ? 2.16 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ARG A 72  ? ? 77.16   -5.77   
2  1 SER A 73  ? ? -90.07  51.00   
3  1 PRO A 161 ? ? -58.03  173.21  
4  1 TYR A 198 ? ? -64.08  99.44   
5  1 ALA A 204 ? ? -174.44 138.90  
6  1 CYS A 270 ? ? 58.04   72.63   
7  1 GLU B 124 ? ? -157.47 86.35   
8  1 GLU B 126 ? ? 56.30   -107.71 
9  1 LEU B 155 ? ? -91.76  46.74   
10 1 LEU B 269 ? ? -82.17  46.27   
11 1 ARG B 270 ? ? -141.95 -3.55   
12 1 GLU B 311 ? ? 76.25   -4.12   
13 1 ASN B 334 ? ? 58.06   -154.21 
14 1 THR C 15  ? ? -82.33  48.61   
15 1 ASP C 35  ? ? 60.06   61.00   
16 1 LYS C 75  ? ? -127.18 -89.61  
17 1 ASP C 79  ? ? 39.84   36.96   
18 1 LEU C 87  ? ? -94.86  30.67   
19 1 MET C 99  ? ? 73.74   -5.10   
20 1 LEU C 202 ? ? 51.60   -146.43 
21 1 LEU C 224 ? ? 59.00   70.30   
22 1 ASP C 227 ? ? 60.06   65.58   
23 1 ILE C 231 ? ? -126.58 -51.48  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9EZ0 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   'Cross-correlation coefficient' 
_em_3d_fitting.details           
;Initial model was rigid body fitted using UCSF chimera and Coot.  Global minimization and B-factor refinement 
was performed in real space using phenix_real.space.refine. Model fit was optimised using molecular dynamics flexible fitting using Namdinator software.
;
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'RIGID BODY FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  1HXS 
_em_3d_fitting_list.pdb_chain_id                  ? 
_em_3d_fitting_list.pdb_chain_residue_range       ? 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                1HXS 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    9EZ0 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'BACK PROJECTION' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     
'Final reconstruction was sharpened with Post-processing in RELION using an inverse B-factor of -76.9 Angstroms.' 
_em_3d_reconstruction.resolution                  3.3 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               2428 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          1 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       '1 x DPBS, 20 mM EDTA, pH 7.0' 
_em_buffer.pH            7.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 VIRUS 
_em_entity_assembly.name                 'Human poliovirus 1 Mahoney' 
_em_entity_assembly.details              'Recombinantly expressed virus-like particle of poliovirus type 1 (Mahoney strain).' 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3' 
# 
_em_image_scans.entry_id                9EZ0 
_em_image_scans.id                      1 
_em_image_scans.number_digital_images   ? 
_em_image_scans.details                 ? 
_em_image_scans.scanner_model           ? 
_em_image_scans.sampling_size           5.0 
_em_image_scans.od_range                ? 
_em_image_scans.quant_bit_size          ? 
_em_image_scans.citation_id             ? 
_em_image_scans.dimension_height        ? 
_em_image_scans.dimension_width         ? 
_em_image_scans.frames_per_image        30 
_em_image_scans.image_recording_id      1 
_em_image_scans.used_frames_per_image   1-30 
# 
_em_imaging.entry_id                        9EZ0 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'DARK FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2900 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           130000 
_em_imaging.calibrated_magnification        47619 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            100 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        C-flat-2/1 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_virus_entity.id                    1 
_em_virus_entity.virus_host_category   ? 
_em_virus_entity.virus_type            'VIRUS-LIKE PARTICLE' 
_em_virus_entity.virus_isolate         SEROTYPE 
_em_virus_entity.entity_assembly_id    1 
_em_virus_entity.enveloped             NO 
_em_virus_entity.empty                 YES 
_em_virus_entity.details               ? 
# 
_em_vitrification.entry_id              9EZ0 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE-PROPANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               
'3-4 ul of sample double blotted for 3.5 seconds with -15 blot force on FEI Vitrobot mark IV.' 
# 
_em_experiment.entry_id                9EZ0 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9EZ0 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        I 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY 1   ? A GLY 1   
2   1 Y 1 A LEU 2   ? A LEU 2   
3   1 Y 1 A GLY 3   ? A GLY 3   
4   1 Y 1 A GLN 4   ? A GLN 4   
5   1 Y 1 A MET 5   ? A MET 5   
6   1 Y 1 A LEU 6   ? A LEU 6   
7   1 Y 1 A GLU 7   ? A GLU 7   
8   1 Y 1 A SER 8   ? A SER 8   
9   1 Y 1 A MET 9   ? A MET 9   
10  1 Y 1 A ILE 10  ? A ILE 10  
11  1 Y 1 A ASP 11  ? A ASP 11  
12  1 Y 1 A ASN 12  ? A ASN 12  
13  1 Y 1 A THR 13  ? A THR 13  
14  1 Y 1 A VAL 14  ? A VAL 14  
15  1 Y 1 A ARG 15  ? A ARG 15  
16  1 Y 1 A GLU 16  ? A GLU 16  
17  1 Y 1 A THR 17  ? A THR 17  
18  1 Y 1 A VAL 18  ? A VAL 18  
19  1 Y 1 A GLY 19  ? A GLY 19  
20  1 Y 1 A ALA 20  ? A ALA 20  
21  1 Y 1 A ALA 21  ? A ALA 21  
22  1 Y 1 A THR 22  ? A THR 22  
23  1 Y 1 A SER 23  ? A SER 23  
24  1 Y 1 A ARG 24  ? A ARG 24  
25  1 Y 1 A ASP 25  ? A ASP 25  
26  1 Y 1 A ALA 26  ? A ALA 26  
27  1 Y 1 A LEU 27  ? A LEU 27  
28  1 Y 1 A PRO 28  ? A PRO 28  
29  1 Y 1 A ASN 29  ? A ASN 29  
30  1 Y 1 A THR 30  ? A THR 30  
31  1 Y 1 A GLU 31  ? A GLU 31  
32  1 Y 1 A ALA 32  ? A ALA 32  
33  1 Y 1 A SER 33  ? A SER 33  
34  1 Y 1 A GLY 34  ? A GLY 34  
35  1 Y 1 A PRO 35  ? A PRO 35  
36  1 Y 1 A THR 36  ? A THR 36  
37  1 Y 1 A HIS 37  ? A HIS 37  
38  1 Y 1 A SER 38  ? A SER 38  
39  1 Y 1 A LYS 39  ? A LYS 39  
40  1 Y 1 A GLU 40  ? A GLU 40  
41  1 Y 1 A ILE 41  ? A ILE 41  
42  1 Y 1 A PRO 42  ? A PRO 42  
43  1 Y 1 A ALA 43  ? A ALA 43  
44  1 Y 1 A LEU 44  ? A LEU 44  
45  1 Y 1 A THR 45  ? A THR 45  
46  1 Y 1 A ALA 46  ? A ALA 46  
47  1 Y 1 A VAL 47  ? A VAL 47  
48  1 Y 1 A GLU 48  ? A GLU 48  
49  1 Y 1 A THR 49  ? A THR 49  
50  1 Y 1 A GLY 50  ? A GLY 50  
51  1 Y 1 A ALA 51  ? A ALA 51  
52  1 Y 1 A THR 52  ? A THR 52  
53  1 Y 1 A ASN 53  ? A ASN 53  
54  1 Y 1 A PRO 54  ? A PRO 54  
55  1 Y 1 A LEU 55  ? A LEU 55  
56  1 Y 1 A VAL 56  ? A VAL 56  
57  1 Y 1 A PRO 57  ? A PRO 57  
58  1 Y 1 A SER 58  ? A SER 58  
59  1 Y 1 A ASP 59  ? A ASP 59  
60  1 Y 1 A THR 60  ? A THR 60  
61  1 Y 1 A VAL 61  ? A VAL 61  
62  1 Y 1 A GLN 62  ? A GLN 62  
63  1 Y 1 A THR 63  ? A THR 63  
64  1 Y 1 A ARG 64  ? A ARG 64  
65  1 Y 1 A HIS 65  ? A HIS 65  
66  1 Y 1 A VAL 66  ? A VAL 66  
67  1 Y 1 A VAL 67  ? A VAL 67  
68  1 Y 1 A GLN 68  ? A GLN 68  
69  1 Y 1 A VAL 215 ? A VAL 215 
70  1 Y 1 A PRO 216 ? A PRO 216 
71  1 Y 1 A LEU 217 ? A LEU 217 
72  1 Y 1 A LYS 218 ? A LYS 218 
73  1 Y 1 A ASP 219 ? A ASP 219 
74  1 Y 1 A GLN 220 ? A GLN 220 
75  1 Y 1 A SER 221 ? A SER 221 
76  1 Y 1 A ALA 222 ? A ALA 222 
77  1 Y 1 A ALA 223 ? A ALA 223 
78  1 Y 1 A LEU 224 ? A LEU 224 
79  1 Y 1 A GLY 225 ? A GLY 225 
80  1 Y 1 A ASP 226 ? A ASP 226 
81  1 Y 1 A SER 227 ? A SER 227 
82  1 Y 1 A LEU 228 ? A LEU 228 
83  1 Y 1 A TYR 229 ? A TYR 229 
84  1 Y 1 A GLY 230 ? A GLY 230 
85  1 Y 1 A ALA 231 ? A ALA 231 
86  1 Y 1 A ALA 232 ? A ALA 232 
87  1 Y 1 A GLY 281 ? A GLY 281 
88  1 Y 1 A PRO 282 ? A PRO 282 
89  1 Y 1 A GLY 283 ? A GLY 283 
90  1 Y 1 A VAL 284 ? A VAL 284 
91  1 Y 1 A ASP 285 ? A ASP 285 
92  1 Y 1 A TYR 286 ? A TYR 286 
93  1 Y 1 A LYS 287 ? A LYS 287 
94  1 Y 1 A ASP 288 ? A ASP 288 
95  1 Y 1 A GLY 289 ? A GLY 289 
96  1 Y 1 A THR 290 ? A THR 290 
97  1 Y 1 A LEU 291 ? A LEU 291 
98  1 Y 1 A THR 292 ? A THR 292 
99  1 Y 1 A PRO 293 ? A PRO 293 
100 1 Y 1 A LEU 294 ? A LEU 294 
101 1 Y 1 A SER 295 ? A SER 295 
102 1 Y 1 A THR 296 ? A THR 296 
103 1 Y 1 A LYS 297 ? A LYS 297 
104 1 Y 1 A ASP 298 ? A ASP 298 
105 1 Y 1 A LEU 299 ? A LEU 299 
106 1 Y 1 A THR 300 ? A THR 300 
107 1 Y 1 A THR 301 ? A THR 301 
108 1 Y 1 A TYR 302 ? A TYR 302 
109 1 Y 1 B MET 1   ? B MET 1   
110 1 Y 1 B GLY 2   ? B GLY 2   
111 1 Y 1 B ALA 3   ? B ALA 3   
112 1 Y 1 B GLN 4   ? B GLN 4   
113 1 Y 1 B VAL 5   ? B VAL 5   
114 1 Y 1 B SER 6   ? B SER 6   
115 1 Y 1 B SER 7   ? B SER 7   
116 1 Y 1 B GLN 8   ? B GLN 8   
117 1 Y 1 B LYS 9   ? B LYS 9   
118 1 Y 1 B VAL 10  ? B VAL 10  
119 1 Y 1 B GLY 11  ? B GLY 11  
120 1 Y 1 B ALA 12  ? B ALA 12  
121 1 Y 1 B HIS 13  ? B HIS 13  
122 1 Y 1 B GLU 14  ? B GLU 14  
123 1 Y 1 B ASN 15  ? B ASN 15  
124 1 Y 1 B SER 16  ? B SER 16  
125 1 Y 1 B ASN 17  ? B ASN 17  
126 1 Y 1 B GLY 18  ? B GLY 18  
127 1 Y 1 B ALA 19  ? B ALA 19  
128 1 Y 1 B TYR 20  ? B TYR 20  
129 1 Y 1 B GLY 21  ? B GLY 21  
130 1 Y 1 B GLY 22  ? B GLY 22  
131 1 Y 1 B SER 23  ? B SER 23  
132 1 Y 1 B THR 24  ? B THR 24  
133 1 Y 1 B ILE 25  ? B ILE 25  
134 1 Y 1 B ASN 26  ? B ASN 26  
135 1 Y 1 B TYR 27  ? B TYR 27  
136 1 Y 1 B THR 28  ? B THR 28  
137 1 Y 1 B THR 29  ? B THR 29  
138 1 Y 1 B ILE 30  ? B ILE 30  
139 1 Y 1 B ASN 31  ? B ASN 31  
140 1 Y 1 B TYR 32  ? B TYR 32  
141 1 Y 1 B TYR 33  ? B TYR 33  
142 1 Y 1 B ARG 34  ? B ARG 34  
143 1 Y 1 B ASP 35  ? B ASP 35  
144 1 Y 1 B SER 36  ? B SER 36  
145 1 Y 1 B ALA 37  ? B ALA 37  
146 1 Y 1 B SER 38  ? B SER 38  
147 1 Y 1 B ASN 39  ? B ASN 39  
148 1 Y 1 B ALA 40  ? B ALA 40  
149 1 Y 1 B ALA 41  ? B ALA 41  
150 1 Y 1 B SER 42  ? B SER 42  
151 1 Y 1 B LYS 43  ? B LYS 43  
152 1 Y 1 B GLN 44  ? B GLN 44  
153 1 Y 1 B ASP 45  ? B ASP 45  
154 1 Y 1 B PHE 46  ? B PHE 46  
155 1 Y 1 B SER 47  ? B SER 47  
156 1 Y 1 B GLN 48  ? B GLN 48  
157 1 Y 1 B ASP 49  ? B ASP 49  
158 1 Y 1 B PRO 50  ? B PRO 50  
159 1 Y 1 B SER 51  ? B SER 51  
160 1 Y 1 B LYS 52  ? B LYS 52  
161 1 Y 1 B PHE 53  ? B PHE 53  
162 1 Y 1 B THR 54  ? B THR 54  
163 1 Y 1 B GLU 55  ? B GLU 55  
164 1 Y 1 B PRO 56  ? B PRO 56  
165 1 Y 1 B ILE 57  ? B ILE 57  
166 1 Y 1 B LYS 58  ? B LYS 58  
167 1 Y 1 B ASP 59  ? B ASP 59  
168 1 Y 1 B VAL 60  ? B VAL 60  
169 1 Y 1 B LEU 61  ? B LEU 61  
170 1 Y 1 B ILE 62  ? B ILE 62  
171 1 Y 1 B LYS 63  ? B LYS 63  
172 1 Y 1 B THR 64  ? B THR 64  
173 1 Y 1 B ALA 65  ? B ALA 65  
174 1 Y 1 B PRO 66  ? B PRO 66  
175 1 Y 1 B MET 67  ? B MET 67  
176 1 Y 1 B LEU 68  ? B LEU 68  
177 1 Y 1 B ASN 69  ? B ASN 69  
178 1 Y 1 B SER 70  ? B SER 70  
179 1 Y 1 B PRO 71  ? B PRO 71  
180 1 Y 1 B ASN 72  ? B ASN 72  
181 1 Y 1 B ILE 73  ? B ILE 73  
182 1 Y 1 B GLU 74  ? B GLU 74  
183 1 Y 1 B ALA 75  ? B ALA 75  
184 1 Y 1 B CYS 76  ? B CYS 76  
185 1 Y 1 B GLY 77  ? B GLY 77  
186 1 Y 1 B TYR 78  ? B TYR 78  
187 1 Y 1 B SER 79  ? B SER 79  
188 1 Y 1 B ASP 80  ? B ASP 80  
189 1 Y 1 B ARG 81  ? B ARG 81  
190 1 Y 1 B VAL 82  ? B VAL 82  
191 1 Y 1 B LEU 83  ? B LEU 83  
192 1 Y 1 B GLU 96  ? B GLU 96  
193 1 Y 1 B ALA 97  ? B ALA 97  
194 1 Y 1 B ASP 113 ? B ASP 113 
195 1 Y 1 B SER 114 ? B SER 114 
196 1 Y 1 B GLU 115 ? B GLU 115 
197 1 Y 1 B ALA 116 ? B ALA 116 
198 1 Y 1 B ASN 117 ? B ASN 117 
199 1 Y 1 B PRO 118 ? B PRO 118 
200 1 Y 1 B VAL 119 ? B VAL 119 
201 1 Y 1 B ASP 120 ? B ASP 120 
202 1 Y 1 B GLN 121 ? B GLN 121 
203 1 Y 1 B ASP 204 ? B ASP 204 
204 1 Y 1 B SER 205 ? B SER 205 
205 1 Y 1 B ASN 206 ? B ASN 206 
206 1 Y 1 B THR 207 ? B THR 207 
207 1 Y 1 B THR 208 ? B THR 208 
208 1 Y 1 B THR 209 ? B THR 209 
209 1 Y 1 B MET 210 ? B MET 210 
210 1 Y 1 B HIS 211 ? B HIS 211 
211 1 Y 1 B THR 229 ? B THR 229 
212 1 Y 1 B PHE 230 ? B PHE 230 
213 1 Y 1 B THR 231 ? B THR 231 
214 1 Y 1 B PRO 232 ? B PRO 232 
215 1 Y 1 B ASP 233 ? B ASP 233 
216 1 Y 1 B ASN 234 ? B ASN 234 
217 1 Y 1 B ASN 235 ? B ASN 235 
218 1 Y 1 B GLN 236 ? B GLN 236 
219 1 Y 1 B THR 237 ? B THR 237 
220 1 Y 1 B SER 238 ? B SER 238 
221 1 Y 1 B PRO 239 ? B PRO 239 
222 1 Y 1 B ALA 240 ? B ALA 240 
223 1 Y 1 B ARG 241 ? B ARG 241 
224 1 Y 1 B ARG 242 ? B ARG 242 
225 1 Y 1 B THR 336 ? B THR 336 
226 1 Y 1 B LEU 337 ? B LEU 337 
227 1 Y 1 B PRO 338 ? B PRO 338 
228 1 Y 1 B ARG 339 ? B ARG 339 
229 1 Y 1 B LEU 340 ? B LEU 340 
230 1 Y 1 B GLN 341 ? B GLN 341 
231 1 Y 1 C GLN 233 ? C GLN 233 
232 1 Y 1 C LYS 234 ? C LYS 234 
233 1 Y 1 C ALA 235 ? C ALA 235 
234 1 Y 1 C LEU 236 ? C LEU 236 
235 1 Y 1 C ALA 237 ? C ALA 237 
236 1 Y 1 C GLN 238 ? C GLN 238 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-10 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           9EZ0 
_em_admin.last_update        2025-01-29 
_em_admin.map_release_date   2025-01-29 
_em_admin.title              
'Poliovirus type 1 (strain Mahoney) expanded conformation stabilised virus-like particle (PV1 SC6b) from a yeast expression system.' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 1  x  ? 1 DPBS 
1 20 mM ? 2 EDTA 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                5.84 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          12081 
_em_entity_assembly_naturalsource.organism             'Human poliovirus 1 Mahoney' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               Mahoney 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          4922 
_em_entity_assembly_recombinant.organism             'Komagataella pastoris' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               6.0 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         41.14 
_em_image_recording.details                             'Pixel sampling was 1.05 A/pixel. Energy filter was Gatan GIF Quantum.' 
_em_image_recording.detector_mode                       COUNTING 
_em_image_recording.film_or_detector_model              'GATAN K2 SUMMIT (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     4282 
# 
_em_particle_selection.details                  
'Particle picking was performed using Xmipp as part of the Scipion software framework.' 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   4578 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'MODEL REFINEMENT'              ? 1  ? ? ? PHENIX 1.20.1_4487: 
'IMAGE ACQUISITION'             ? 2  1 1 1 ?      ?            
'PARTICLE SELECTION'            ? 3  1 1 1 ?      ?            
'VOLUME SELECTION'              ? 4  1 1 1 ?      ?            
CLASSIFICATION                  ? 5  1 1 1 ?      ?            
MASKING                         ? 6  1 1 1 ?      ?            
RECONSTRUCTION                  ? 7  1 1 1 ?      ?            
'INITIAL EULER ASSIGNMENT'      ? 8  1 1 1 ?      ?            
'FINAL EULER ASSIGNMENT'        ? 9  1 1 1 ?      ?            
'CTF CORRECTION'                ? 10 1 1 1 ?      ?            
'LAYERLINE INDEXING'            ? 11 1 1 1 ?      ?            
'DIFFRACTION INDEXING'          ? 12 1 1 1 ?      ?            
'MODEL FITTING'                 ? 13 1 1 1 ?      ?            
'SERIES ALIGNMENT'              ? 14 1 1 1 ?      ?            
'MOLECULAR REPLACEMENT'         ? 15 1 1 1 ?      ?            
'LATTICE DISTORTION CORRECTION' ? 16 1 1 1 ?      ?            
'SYMMETRY DETERMINATION'        ? 17 1 1 1 ?      ?            
'CRYSTALLOGRAPHY MERGING'       ? 18 1 1 1 ?      ?            
OTHER                           ? 19 1 1 1 ?      ?            
# 
_em_specimen.concentration           1.1 
_em_specimen.details                 'Sample purified by sucrose density gradient ultracentrifugation.' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_em_virus_natural_host.entity_assembly_id   1 
_em_virus_natural_host.id                   1 
_em_virus_natural_host.ncbi_tax_id          9606 
_em_virus_natural_host.organism             'Homo sapiens' 
_em_virus_natural_host.strain               ? 
# 
_em_virus_shell.diameter             310 
_em_virus_shell.entity_assembly_id   1 
_em_virus_shell.id                   1 
_em_virus_shell.name                 'Virus shell 1' 
_em_virus_shell.triangulation        1 
# 
_pdbx_audit_support.funding_organization   'Bill & Melinda Gates Foundation' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           RG.IMCB.I8-TSA-083 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1HXS 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9EZ0 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . HIS A 1 69  ? 175.939 256.913 314.715 1.00 84.41  ? 69  HIS A N   1 
ATOM 2    C CA  . HIS A 1 69  ? 176.708 255.694 314.928 1.00 88.15  ? 69  HIS A CA  1 
ATOM 3    C C   . HIS A 1 69  ? 177.700 255.903 316.067 1.00 90.52  ? 69  HIS A C   1 
ATOM 4    O O   . HIS A 1 69  ? 178.470 256.863 316.061 1.00 87.90  ? 69  HIS A O   1 
ATOM 5    C CB  . HIS A 1 69  ? 177.435 255.289 313.646 1.00 88.31  ? 69  HIS A CB  1 
ATOM 6    C CG  . HIS A 1 69  ? 177.854 253.853 313.618 1.00 90.11  ? 69  HIS A CG  1 
ATOM 7    N ND1 . HIS A 1 69  ? 177.894 253.066 314.749 1.00 92.16  ? 69  HIS A ND1 1 
ATOM 8    C CD2 . HIS A 1 69  ? 178.246 253.059 312.594 1.00 88.99  ? 69  HIS A CD2 1 
ATOM 9    C CE1 . HIS A 1 69  ? 178.296 251.851 314.423 1.00 90.16  ? 69  HIS A CE1 1 
ATOM 10   N NE2 . HIS A 1 69  ? 178.516 251.820 313.121 1.00 91.01  ? 69  HIS A NE2 1 
ATOM 11   N N   . ARG A 1 70  ? 177.676 254.999 317.044 1.00 77.32  ? 70  ARG A N   1 
ATOM 12   C CA  . ARG A 1 70  ? 178.473 255.153 318.249 1.00 74.12  ? 70  ARG A CA  1 
ATOM 13   C C   . ARG A 1 70  ? 179.885 254.616 318.029 1.00 72.89  ? 70  ARG A C   1 
ATOM 14   O O   . ARG A 1 70  ? 180.205 254.034 316.990 1.00 74.10  ? 70  ARG A O   1 
ATOM 15   C CB  . ARG A 1 70  ? 177.791 254.454 319.419 1.00 70.16  ? 70  ARG A CB  1 
ATOM 16   C CG  . ARG A 1 70  ? 176.410 255.003 319.718 1.00 68.22  ? 70  ARG A CG  1 
ATOM 17   C CD  . ARG A 1 70  ? 175.669 254.140 320.711 1.00 67.95  ? 70  ARG A CD  1 
ATOM 18   N NE  . ARG A 1 70  ? 175.556 252.767 320.240 1.00 72.60  ? 70  ARG A NE  1 
ATOM 19   C CZ  . ARG A 1 70  ? 174.755 251.859 320.776 1.00 74.89  ? 70  ARG A CZ  1 
ATOM 20   N NH1 . ARG A 1 70  ? 173.958 252.152 321.786 1.00 72.19  ? 70  ARG A NH1 1 
ATOM 21   N NH2 . ARG A 1 70  ? 174.751 250.626 320.279 1.00 75.90  ? 70  ARG A NH2 1 
ATOM 22   N N   . SER A 1 71  ? 180.741 254.812 319.032 1.00 70.40  ? 71  SER A N   1 
ATOM 23   C CA  . SER A 1 71  ? 182.165 254.528 318.917 1.00 70.46  ? 71  SER A CA  1 
ATOM 24   C C   . SER A 1 71  ? 182.607 253.379 319.814 1.00 70.29  ? 71  SER A C   1 
ATOM 25   O O   . SER A 1 71  ? 183.192 252.408 319.327 1.00 70.01  ? 71  SER A O   1 
ATOM 26   C CB  . SER A 1 71  ? 182.967 255.789 319.256 1.00 74.94  ? 71  SER A CB  1 
ATOM 27   O OG  . SER A 1 71  ? 182.746 256.176 320.600 1.00 74.23  ? 71  SER A OG  1 
ATOM 28   N N   . ARG A 1 72  ? 182.349 253.473 321.117 1.00 71.24  ? 72  ARG A N   1 
ATOM 29   C CA  . ARG A 1 72  ? 182.818 252.543 322.144 1.00 72.90  ? 72  ARG A CA  1 
ATOM 30   C C   . ARG A 1 72  ? 184.282 252.788 322.479 1.00 70.48  ? 72  ARG A C   1 
ATOM 31   O O   . ARG A 1 72  ? 184.797 252.170 323.418 1.00 68.22  ? 72  ARG A O   1 
ATOM 32   C CB  . ARG A 1 72  ? 182.636 251.077 321.735 1.00 72.19  ? 72  ARG A CB  1 
ATOM 33   C CG  . ARG A 1 72  ? 182.810 250.072 322.864 1.00 67.26  ? 72  ARG A CG  1 
ATOM 34   C CD  . ARG A 1 72  ? 182.741 248.650 322.337 1.00 67.29  ? 72  ARG A CD  1 
ATOM 35   N NE  . ARG A 1 72  ? 181.382 248.122 322.341 1.00 68.15  ? 72  ARG A NE  1 
ATOM 36   C CZ  . ARG A 1 72  ? 180.924 247.206 323.185 1.00 70.96  ? 72  ARG A CZ  1 
ATOM 37   N NH1 . ARG A 1 72  ? 181.696 246.670 324.116 1.00 69.75  ? 72  ARG A NH1 1 
ATOM 38   N NH2 . ARG A 1 72  ? 179.660 246.808 323.086 1.00 71.15  ? 72  ARG A NH2 1 
ATOM 39   N N   . SER A 1 73  ? 184.966 253.675 321.767 1.00 69.51  ? 73  SER A N   1 
ATOM 40   C CA  . SER A 1 73  ? 186.366 253.984 322.061 1.00 67.34  ? 73  SER A CA  1 
ATOM 41   C C   . SER A 1 73  ? 186.475 255.131 323.056 1.00 63.59  ? 73  SER A C   1 
ATOM 42   O O   . SER A 1 73  ? 187.183 256.113 322.848 1.00 67.06  ? 73  SER A O   1 
ATOM 43   C CB  . SER A 1 73  ? 187.112 254.305 320.774 1.00 70.24  ? 73  SER A CB  1 
ATOM 44   O OG  . SER A 1 73  ? 187.094 253.196 319.893 1.00 68.92  ? 73  SER A OG  1 
ATOM 45   N N   . GLU A 1 74  ? 185.749 254.996 324.159 1.00 60.48  ? 74  GLU A N   1 
ATOM 46   C CA  . GLU A 1 74  ? 185.925 255.837 325.327 1.00 59.17  ? 74  GLU A CA  1 
ATOM 47   C C   . GLU A 1 74  ? 185.913 255.012 326.601 1.00 65.21  ? 74  GLU A C   1 
ATOM 48   O O   . GLU A 1 74  ? 186.080 255.570 327.691 1.00 65.95  ? 74  GLU A O   1 
ATOM 49   C CB  . GLU A 1 74  ? 184.831 256.912 325.391 1.00 64.82  ? 74  GLU A CB  1 
ATOM 50   C CG  . GLU A 1 74  ? 184.924 257.818 326.607 1.00 69.22  ? 74  GLU A CG  1 
ATOM 51   C CD  . GLU A 1 74  ? 184.202 259.133 326.415 1.00 73.58  ? 74  GLU A CD  1 
ATOM 52   O OE1 . GLU A 1 74  ? 183.635 259.347 325.326 1.00 72.92  ? 74  GLU A OE1 1 
ATOM 53   O OE2 . GLU A 1 74  ? 184.207 259.957 327.352 1.00 73.15  ? 74  GLU A OE2 1 
ATOM 54   N N   . SER A 1 75  ? 185.730 253.697 326.490 1.00 62.98  ? 75  SER A N   1 
ATOM 55   C CA  . SER A 1 75  ? 185.761 252.781 327.617 1.00 58.93  ? 75  SER A CA  1 
ATOM 56   C C   . SER A 1 75  ? 187.019 251.925 327.493 1.00 62.83  ? 75  SER A C   1 
ATOM 57   O O   . SER A 1 75  ? 187.172 250.907 328.168 1.00 69.70  ? 75  SER A O   1 
ATOM 58   C CB  . SER A 1 75  ? 184.500 251.927 327.656 1.00 65.18  ? 75  SER A CB  1 
ATOM 59   O OG  . SER A 1 75  ? 184.329 251.241 326.430 1.00 63.53  ? 75  SER A OG  1 
ATOM 60   N N   . SER A 1 76  ? 187.928 252.345 326.622 1.00 56.25  ? 76  SER A N   1 
ATOM 61   C CA  . SER A 1 76  ? 189.202 251.674 326.449 1.00 53.99  ? 76  SER A CA  1 
ATOM 62   C C   . SER A 1 76  ? 190.021 251.831 327.720 1.00 54.49  ? 76  SER A C   1 
ATOM 63   O O   . SER A 1 76  ? 189.792 252.738 328.524 1.00 53.01  ? 76  SER A O   1 
ATOM 64   C CB  . SER A 1 76  ? 189.967 252.243 325.253 1.00 56.07  ? 76  SER A CB  1 
ATOM 65   O OG  . SER A 1 76  ? 190.234 253.620 325.435 1.00 63.51  ? 76  SER A OG  1 
ATOM 66   N N   . ILE A 1 77  ? 190.977 250.922 327.905 1.00 54.44  ? 77  ILE A N   1 
ATOM 67   C CA  . ILE A 1 77  ? 191.773 250.946 329.126 1.00 51.31  ? 77  ILE A CA  1 
ATOM 68   C C   . ILE A 1 77  ? 192.501 252.274 329.256 1.00 56.61  ? 77  ILE A C   1 
ATOM 69   O O   . ILE A 1 77  ? 192.478 252.909 330.316 1.00 57.92  ? 77  ILE A O   1 
ATOM 70   C CB  . ILE A 1 77  ? 192.757 249.764 329.150 1.00 50.31  ? 77  ILE A CB  1 
ATOM 71   C CG1 . ILE A 1 77  ? 192.010 248.435 329.024 1.00 52.07  ? 77  ILE A CG1 1 
ATOM 72   C CG2 . ILE A 1 77  ? 193.573 249.790 330.425 1.00 50.84  ? 77  ILE A CG2 1 
ATOM 73   C CD1 . ILE A 1 77  ? 190.899 248.245 330.036 1.00 50.28  ? 77  ILE A CD1 1 
ATOM 74   N N   . GLU A 1 78  ? 193.160 252.716 328.185 1.00 58.31  ? 78  GLU A N   1 
ATOM 75   C CA  . GLU A 1 78  ? 193.928 253.953 328.264 1.00 56.66  ? 78  GLU A CA  1 
ATOM 76   C C   . GLU A 1 78  ? 193.017 255.152 328.497 1.00 58.52  ? 78  GLU A C   1 
ATOM 77   O O   . GLU A 1 78  ? 193.339 256.041 329.293 1.00 59.32  ? 78  GLU A O   1 
ATOM 78   C CB  . GLU A 1 78  ? 194.757 254.133 326.995 1.00 57.99  ? 78  GLU A CB  1 
ATOM 79   C CG  . GLU A 1 78  ? 195.845 255.189 327.121 1.00 64.47  ? 78  GLU A CG  1 
ATOM 80   C CD  . GLU A 1 78  ? 197.150 254.781 326.461 1.00 72.15  ? 78  GLU A CD  1 
ATOM 81   O OE1 . GLU A 1 78  ? 197.488 253.579 326.491 1.00 70.81  ? 78  GLU A OE1 1 
ATOM 82   O OE2 . GLU A 1 78  ? 197.841 255.664 325.912 1.00 70.65  ? 78  GLU A OE2 1 
ATOM 83   N N   . SER A 1 79  ? 191.869 255.193 327.818 1.00 57.67  ? 79  SER A N   1 
ATOM 84   C CA  . SER A 1 79  ? 190.928 256.287 328.033 1.00 57.01  ? 79  SER A CA  1 
ATOM 85   C C   . SER A 1 79  ? 190.375 256.279 329.450 1.00 52.40  ? 79  SER A C   1 
ATOM 86   O O   . SER A 1 79  ? 190.188 257.344 330.048 1.00 53.56  ? 79  SER A O   1 
ATOM 87   C CB  . SER A 1 79  ? 189.786 256.199 327.025 1.00 53.19  ? 79  SER A CB  1 
ATOM 88   O OG  . SER A 1 79  ? 190.283 256.188 325.700 1.00 63.26  ? 79  SER A OG  1 
ATOM 89   N N   . PHE A 1 80  ? 190.096 255.098 329.995 1.00 47.28  ? 80  PHE A N   1 
ATOM 90   C CA  . PHE A 1 80  ? 189.576 255.000 331.351 1.00 46.69  ? 80  PHE A CA  1 
ATOM 91   C C   . PHE A 1 80  ? 190.617 255.414 332.383 1.00 48.13  ? 80  PHE A C   1 
ATOM 92   O O   . PHE A 1 80  ? 190.283 256.072 333.374 1.00 47.93  ? 80  PHE A O   1 
ATOM 93   C CB  . PHE A 1 80  ? 189.098 253.571 331.606 1.00 39.45  ? 80  PHE A CB  1 
ATOM 94   C CG  . PHE A 1 80  ? 188.446 253.371 332.939 1.00 40.14  ? 80  PHE A CG  1 
ATOM 95   C CD1 . PHE A 1 80  ? 187.317 254.083 333.285 1.00 47.08  ? 80  PHE A CD1 1 
ATOM 96   C CD2 . PHE A 1 80  ? 188.947 252.449 333.837 1.00 46.17  ? 80  PHE A CD2 1 
ATOM 97   C CE1 . PHE A 1 80  ? 186.712 253.892 334.505 1.00 51.69  ? 80  PHE A CE1 1 
ATOM 98   C CE2 . PHE A 1 80  ? 188.343 252.255 335.058 1.00 42.31  ? 80  PHE A CE2 1 
ATOM 99   C CZ  . PHE A 1 80  ? 187.225 252.976 335.391 1.00 50.53  ? 80  PHE A CZ  1 
ATOM 100  N N   . PHE A 1 81  ? 191.880 255.051 332.165 1.00 45.45  ? 81  PHE A N   1 
ATOM 101  C CA  . PHE A 1 81  ? 192.931 255.246 333.156 1.00 40.07  ? 81  PHE A CA  1 
ATOM 102  C C   . PHE A 1 81  ? 193.798 256.468 332.905 1.00 50.99  ? 81  PHE A C   1 
ATOM 103  O O   . PHE A 1 81  ? 194.247 257.097 333.868 1.00 50.94  ? 81  PHE A O   1 
ATOM 104  C CB  . PHE A 1 81  ? 193.842 254.017 333.212 1.00 41.23  ? 81  PHE A CB  1 
ATOM 105  C CG  . PHE A 1 81  ? 193.244 252.854 333.933 1.00 44.63  ? 81  PHE A CG  1 
ATOM 106  C CD1 . PHE A 1 81  ? 193.276 252.791 335.312 1.00 45.09  ? 81  PHE A CD1 1 
ATOM 107  C CD2 . PHE A 1 81  ? 192.657 251.819 333.235 1.00 44.66  ? 81  PHE A CD2 1 
ATOM 108  C CE1 . PHE A 1 81  ? 192.729 251.724 335.977 1.00 50.34  ? 81  PHE A CE1 1 
ATOM 109  C CE2 . PHE A 1 81  ? 192.108 250.749 333.897 1.00 44.07  ? 81  PHE A CE2 1 
ATOM 110  C CZ  . PHE A 1 81  ? 192.144 250.700 335.268 1.00 44.84  ? 81  PHE A CZ  1 
ATOM 111  N N   . ALA A 1 82  ? 194.051 256.826 331.649 1.00 59.62  ? 82  ALA A N   1 
ATOM 112  C CA  . ALA A 1 82  ? 195.021 257.875 331.367 1.00 52.76  ? 82  ALA A CA  1 
ATOM 113  C C   . ALA A 1 82  ? 194.457 259.241 331.728 1.00 58.78  ? 82  ALA A C   1 
ATOM 114  O O   . ALA A 1 82  ? 194.278 260.096 330.856 1.00 60.66  ? 82  ALA A O   1 
ATOM 115  C CB  . ALA A 1 82  ? 195.434 257.847 329.896 1.00 53.40  ? 82  ALA A CB  1 
ATOM 116  N N   . ARG A 1 83  ? 194.192 259.457 333.013 1.00 61.31  ? 83  ARG A N   1 
ATOM 117  C CA  . ARG A 1 83  ? 193.719 260.734 333.519 1.00 60.48  ? 83  ARG A CA  1 
ATOM 118  C C   . ARG A 1 83  ? 194.608 261.152 334.678 1.00 57.72  ? 83  ARG A C   1 
ATOM 119  O O   . ARG A 1 83  ? 194.755 260.412 335.653 1.00 55.07  ? 83  ARG A O   1 
ATOM 120  C CB  . ARG A 1 83  ? 192.263 260.652 333.994 1.00 57.86  ? 83  ARG A CB  1 
ATOM 121  C CG  . ARG A 1 83  ? 191.315 259.925 333.052 1.00 53.10  ? 83  ARG A CG  1 
ATOM 122  C CD  . ARG A 1 83  ? 191.217 260.608 331.702 1.00 58.95  ? 83  ARG A CD  1 
ATOM 123  N NE  . ARG A 1 83  ? 190.250 259.950 330.829 1.00 58.50  ? 83  ARG A NE  1 
ATOM 124  C CZ  . ARG A 1 83  ? 189.030 260.400 330.572 1.00 61.65  ? 83  ARG A CZ  1 
ATOM 125  N NH1 . ARG A 1 83  ? 188.581 261.532 331.091 1.00 60.72  ? 83  ARG A NH1 1 
ATOM 126  N NH2 . ARG A 1 83  ? 188.239 259.699 329.766 1.00 64.80  ? 83  ARG A NH2 1 
ATOM 127  N N   . GLY A 1 84  ? 195.199 262.338 334.571 1.00 48.89  ? 84  GLY A N   1 
ATOM 128  C CA  . GLY A 1 84  ? 196.042 262.831 335.638 1.00 46.93  ? 84  GLY A CA  1 
ATOM 129  C C   . GLY A 1 84  ? 195.241 263.160 336.882 1.00 47.84  ? 84  GLY A C   1 
ATOM 130  O O   . GLY A 1 84  ? 194.113 263.643 336.819 1.00 51.82  ? 84  GLY A O   1 
ATOM 131  N N   . ALA A 1 85  ? 195.840 262.884 338.036 1.00 45.16  ? 85  ALA A N   1 
ATOM 132  C CA  . ALA A 1 85  ? 195.196 263.158 339.310 1.00 50.77  ? 85  ALA A CA  1 
ATOM 133  C C   . ALA A 1 85  ? 196.261 263.277 340.386 1.00 51.79  ? 85  ALA A C   1 
ATOM 134  O O   . ALA A 1 85  ? 197.176 262.454 340.453 1.00 48.27  ? 85  ALA A O   1 
ATOM 135  C CB  . ALA A 1 85  ? 194.194 262.061 339.678 1.00 56.46  ? 85  ALA A CB  1 
ATOM 136  N N   . CYS A 1 86  ? 196.130 264.298 341.228 1.00 52.27  ? 86  CYS A N   1 
ATOM 137  C CA  . CYS A 1 86  ? 197.123 264.536 342.264 1.00 49.98  ? 86  CYS A CA  1 
ATOM 138  C C   . CYS A 1 86  ? 197.261 263.310 343.153 1.00 53.01  ? 86  CYS A C   1 
ATOM 139  O O   . CYS A 1 86  ? 196.264 262.749 343.615 1.00 53.50  ? 86  CYS A O   1 
ATOM 140  C CB  . CYS A 1 86  ? 196.733 265.753 343.100 1.00 50.38  ? 86  CYS A CB  1 
ATOM 141  S SG  . CYS A 1 86  ? 197.764 266.009 344.559 1.00 58.95  ? 86  CYS A SG  1 
ATOM 142  N N   . VAL A 1 87  ? 198.506 262.892 343.388 1.00 59.60  ? 87  VAL A N   1 
ATOM 143  C CA  . VAL A 1 87  ? 198.780 261.738 344.239 1.00 54.10  ? 87  VAL A CA  1 
ATOM 144  C C   . VAL A 1 87  ? 199.433 262.120 345.557 1.00 57.52  ? 87  VAL A C   1 
ATOM 145  O O   . VAL A 1 87  ? 199.417 261.308 346.495 1.00 59.72  ? 87  VAL A O   1 
ATOM 146  C CB  . VAL A 1 87  ? 199.660 260.699 343.512 1.00 52.68  ? 87  VAL A CB  1 
ATOM 147  C CG1 . VAL A 1 87  ? 198.903 260.077 342.359 1.00 52.74  ? 87  VAL A CG1 1 
ATOM 148  C CG2 . VAL A 1 87  ? 200.944 261.334 343.022 1.00 53.33  ? 87  VAL A CG2 1 
ATOM 149  N N   . THR A 1 88  ? 200.004 263.317 345.669 1.00 61.78  ? 88  THR A N   1 
ATOM 150  C CA  . THR A 1 88  ? 200.580 263.747 346.934 1.00 61.53  ? 88  THR A CA  1 
ATOM 151  C C   . THR A 1 88  ? 200.884 265.237 346.880 1.00 60.71  ? 88  THR A C   1 
ATOM 152  O O   . THR A 1 88  ? 200.983 265.841 345.806 1.00 59.67  ? 88  THR A O   1 
ATOM 153  C CB  . THR A 1 88  ? 201.849 262.961 347.267 1.00 64.45  ? 88  THR A CB  1 
ATOM 154  O OG1 . THR A 1 88  ? 202.242 263.233 348.617 1.00 66.68  ? 88  THR A OG1 1 
ATOM 155  C CG2 . THR A 1 88  ? 202.972 263.357 346.330 1.00 63.75  ? 88  THR A CG2 1 
ATOM 156  N N   . ILE A 1 89  ? 201.051 265.814 348.071 1.00 63.53  ? 89  ILE A N   1 
ATOM 157  C CA  . ILE A 1 89  ? 201.414 267.215 348.248 1.00 60.43  ? 89  ILE A CA  1 
ATOM 158  C C   . ILE A 1 89  ? 202.632 267.280 349.160 1.00 66.67  ? 89  ILE A C   1 
ATOM 159  O O   . ILE A 1 89  ? 202.503 267.323 350.388 1.00 69.43  ? 89  ILE A O   1 
ATOM 160  C CB  . ILE A 1 89  ? 200.243 268.027 348.830 1.00 58.98  ? 89  ILE A CB  1 
ATOM 161  C CG1 . ILE A 1 89  ? 199.001 267.869 347.949 1.00 63.28  ? 89  ILE A CG1 1 
ATOM 162  C CG2 . ILE A 1 89  ? 200.627 269.494 348.961 1.00 59.93  ? 89  ILE A CG2 1 
ATOM 163  C CD1 . ILE A 1 89  ? 197.780 268.609 348.460 1.00 63.82  ? 89  ILE A CD1 1 
ATOM 164  N N   . MET A 1 90  ? 203.820 267.302 348.564 1.00 73.15  ? 90  MET A N   1 
ATOM 165  C CA  . MET A 1 90  ? 205.069 267.253 349.313 1.00 68.58  ? 90  MET A CA  1 
ATOM 166  C C   . MET A 1 90  ? 205.421 268.650 349.809 1.00 67.76  ? 90  MET A C   1 
ATOM 167  O O   . MET A 1 90  ? 205.560 269.579 349.010 1.00 62.90  ? 90  MET A O   1 
ATOM 168  C CB  . MET A 1 90  ? 206.185 266.705 348.427 1.00 61.31  ? 90  MET A CB  1 
ATOM 169  C CG  . MET A 1 90  ? 205.803 265.459 347.647 1.00 63.01  ? 90  MET A CG  1 
ATOM 170  S SD  . MET A 1 90  ? 207.051 264.972 346.446 1.00 80.61  ? 90  MET A SD  1 
ATOM 171  C CE  . MET A 1 90  ? 208.457 264.699 347.514 1.00 67.80  ? 90  MET A CE  1 
ATOM 172  N N   . THR A 1 91  ? 205.583 268.797 351.118 1.00 73.70  ? 91  THR A N   1 
ATOM 173  C CA  . THR A 1 91  ? 205.859 270.089 351.730 1.00 73.61  ? 91  THR A CA  1 
ATOM 174  C C   . THR A 1 91  ? 207.351 270.226 352.002 1.00 71.57  ? 91  THR A C   1 
ATOM 175  O O   . THR A 1 91  ? 207.954 269.356 352.638 1.00 69.12  ? 91  THR A O   1 
ATOM 176  C CB  . THR A 1 91  ? 205.075 270.252 353.033 1.00 71.97  ? 91  THR A CB  1 
ATOM 177  O OG1 . THR A 1 91  ? 203.672 270.158 352.764 1.00 73.03  ? 91  THR A OG1 1 
ATOM 178  C CG2 . THR A 1 91  ? 205.378 271.597 353.678 1.00 69.07  ? 91  THR A CG2 1 
ATOM 179  N N   . VAL A 1 92  ? 207.939 271.319 351.519 1.00 76.13  ? 92  VAL A N   1 
ATOM 180  C CA  . VAL A 1 92  ? 209.328 271.661 351.787 1.00 77.66  ? 92  VAL A CA  1 
ATOM 181  C C   . VAL A 1 92  ? 209.372 273.119 352.222 1.00 83.80  ? 92  VAL A C   1 
ATOM 182  O O   . VAL A 1 92  ? 208.366 273.827 352.202 1.00 85.54  ? 92  VAL A O   1 
ATOM 183  C CB  . VAL A 1 92  ? 210.240 271.427 350.564 1.00 76.13  ? 92  VAL A CB  1 
ATOM 184  C CG1 . VAL A 1 92  ? 210.013 270.047 349.988 1.00 74.94  ? 92  VAL A CG1 1 
ATOM 185  C CG2 . VAL A 1 92  ? 209.999 272.476 349.506 1.00 77.17  ? 92  VAL A CG2 1 
ATOM 186  N N   . ASP A 1 93  ? 210.557 273.572 352.617 1.00 93.85  ? 93  ASP A N   1 
ATOM 187  C CA  . ASP A 1 93  ? 210.700 274.970 352.995 1.00 95.05  ? 93  ASP A CA  1 
ATOM 188  C C   . ASP A 1 93  ? 212.166 275.365 352.935 1.00 95.83  ? 93  ASP A C   1 
ATOM 189  O O   . ASP A 1 93  ? 213.054 274.558 353.220 1.00 95.58  ? 93  ASP A O   1 
ATOM 190  C CB  . ASP A 1 93  ? 210.135 275.233 354.396 1.00 94.13  ? 93  ASP A CB  1 
ATOM 191  C CG  . ASP A 1 93  ? 211.066 274.774 355.496 1.00 96.53  ? 93  ASP A CG  1 
ATOM 192  O OD1 . ASP A 1 93  ? 211.777 273.769 355.296 1.00 99.63  ? 93  ASP A OD1 1 
ATOM 193  O OD2 . ASP A 1 93  ? 211.088 275.421 356.563 1.00 96.67  ? 93  ASP A OD2 1 
ATOM 194  N N   . ASN A 1 94  ? 212.403 276.613 352.554 1.00 100.46 ? 94  ASN A N   1 
ATOM 195  C CA  . ASN A 1 94  ? 213.748 277.165 352.574 1.00 97.35  ? 94  ASN A CA  1 
ATOM 196  C C   . ASN A 1 94  ? 214.095 277.571 354.001 1.00 98.70  ? 94  ASN A C   1 
ATOM 197  O O   . ASN A 1 94  ? 213.420 278.437 354.566 1.00 99.81  ? 94  ASN A O   1 
ATOM 198  C CB  . ASN A 1 94  ? 213.841 278.367 351.645 1.00 97.14  ? 94  ASN A CB  1 
ATOM 199  C CG  . ASN A 1 94  ? 215.246 278.926 351.548 1.00 97.94  ? 94  ASN A CG  1 
ATOM 200  O OD1 . ASN A 1 94  ? 216.104 278.637 352.381 1.00 100.18 ? 94  ASN A OD1 1 
ATOM 201  N ND2 . ASN A 1 94  ? 215.486 279.741 350.528 1.00 99.30  ? 94  ASN A ND2 1 
ATOM 202  N N   . PRO A 1 95  ? 215.120 276.984 354.616 1.00 109.78 ? 95  PRO A N   1 
ATOM 203  C CA  . PRO A 1 95  ? 215.419 277.324 356.011 1.00 111.20 ? 95  PRO A CA  1 
ATOM 204  C C   . PRO A 1 95  ? 215.781 278.793 356.157 1.00 113.34 ? 95  PRO A C   1 
ATOM 205  O O   . PRO A 1 95  ? 216.439 279.380 355.296 1.00 113.04 ? 95  PRO A O   1 
ATOM 206  C CB  . PRO A 1 95  ? 216.600 276.411 356.355 1.00 110.84 ? 95  PRO A CB  1 
ATOM 207  C CG  . PRO A 1 95  ? 217.226 276.090 355.047 1.00 109.66 ? 95  PRO A CG  1 
ATOM 208  C CD  . PRO A 1 95  ? 216.101 276.038 354.061 1.00 109.04 ? 95  PRO A CD  1 
ATOM 209  N N   . ALA A 1 96  ? 215.341 279.386 357.262 1.00 125.11 ? 96  ALA A N   1 
ATOM 210  C CA  . ALA A 1 96  ? 215.713 280.758 357.564 1.00 125.09 ? 96  ALA A CA  1 
ATOM 211  C C   . ALA A 1 96  ? 217.192 280.833 357.921 1.00 126.79 ? 96  ALA A C   1 
ATOM 212  O O   . ALA A 1 96  ? 217.796 279.857 358.373 1.00 127.22 ? 96  ALA A O   1 
ATOM 213  C CB  . ALA A 1 96  ? 214.866 281.301 358.713 1.00 123.11 ? 96  ALA A CB  1 
ATOM 214  N N   . SER A 1 97  ? 217.779 282.012 357.710 1.00 122.32 ? 97  SER A N   1 
ATOM 215  C CA  . SER A 1 97  ? 219.190 282.193 358.027 1.00 120.81 ? 97  SER A CA  1 
ATOM 216  C C   . SER A 1 97  ? 219.481 281.940 359.499 1.00 122.79 ? 97  SER A C   1 
ATOM 217  O O   . SER A 1 97  ? 220.625 281.627 359.848 1.00 121.33 ? 97  SER A O   1 
ATOM 218  C CB  . SER A 1 97  ? 219.640 283.600 357.640 1.00 121.34 ? 97  SER A CB  1 
ATOM 219  O OG  . SER A 1 97  ? 219.628 283.761 356.233 1.00 120.16 ? 97  SER A OG  1 
ATOM 220  N N   . THR A 1 98  ? 218.478 282.068 360.370 1.00 133.37 ? 98  THR A N   1 
ATOM 221  C CA  . THR A 1 98  ? 218.653 281.711 361.772 1.00 133.76 ? 98  THR A CA  1 
ATOM 222  C C   . THR A 1 98  ? 218.853 280.215 361.971 1.00 133.89 ? 98  THR A C   1 
ATOM 223  O O   . THR A 1 98  ? 219.260 279.802 363.062 1.00 132.61 ? 98  THR A O   1 
ATOM 224  C CB  . THR A 1 98  ? 217.449 282.182 362.594 1.00 131.49 ? 98  THR A CB  1 
ATOM 225  O OG1 . THR A 1 98  ? 217.640 281.829 363.970 1.00 131.93 ? 98  THR A OG1 1 
ATOM 226  C CG2 . THR A 1 98  ? 216.157 281.550 362.086 1.00 129.54 ? 98  THR A CG2 1 
ATOM 227  N N   . THR A 1 99  ? 218.582 279.401 360.950 1.00 134.16 ? 99  THR A N   1 
ATOM 228  C CA  . THR A 1 99  ? 218.783 277.954 361.019 1.00 132.41 ? 99  THR A CA  1 
ATOM 229  C C   . THR A 1 99  ? 218.003 277.340 362.178 1.00 132.46 ? 99  THR A C   1 
ATOM 230  O O   . THR A 1 99  ? 218.505 276.478 362.902 1.00 131.35 ? 99  THR A O   1 
ATOM 231  C CB  . THR A 1 99  ? 220.270 277.608 361.131 1.00 131.92 ? 99  THR A CB  1 
ATOM 232  O OG1 . THR A 1 99  ? 220.795 278.119 362.363 1.00 132.53 ? 99  THR A OG1 1 
ATOM 233  C CG2 . THR A 1 99  ? 221.048 278.200 359.964 1.00 130.95 ? 99  THR A CG2 1 
ATOM 234  N N   . ASN A 1 100 ? 216.758 277.788 362.358 1.00 130.77 ? 100 ASN A N   1 
ATOM 235  C CA  . ASN A 1 100 ? 215.914 277.200 363.392 1.00 131.39 ? 100 ASN A CA  1 
ATOM 236  C C   . ASN A 1 100 ? 215.686 275.718 363.127 1.00 130.13 ? 100 ASN A C   1 
ATOM 237  O O   . ASN A 1 100 ? 215.734 274.898 364.051 1.00 126.78 ? 100 ASN A O   1 
ATOM 238  C CB  . ASN A 1 100 ? 214.584 277.951 363.474 1.00 128.91 ? 100 ASN A CB  1 
ATOM 239  C CG  . ASN A 1 100 ? 213.811 277.915 362.171 1.00 127.48 ? 100 ASN A CG  1 
ATOM 240  O OD1 . ASN A 1 100 ? 214.121 278.645 361.230 1.00 127.52 ? 100 ASN A OD1 1 
ATOM 241  N ND2 . ASN A 1 100 ? 212.790 277.067 362.113 1.00 126.29 ? 100 ASN A ND2 1 
ATOM 242  N N   . LYS A 1 101 ? 215.437 275.355 361.871 1.00 123.41 ? 101 LYS A N   1 
ATOM 243  C CA  . LYS A 1 101 ? 215.357 273.961 361.462 1.00 120.60 ? 101 LYS A CA  1 
ATOM 244  C C   . LYS A 1 101 ? 215.929 273.832 360.060 1.00 121.43 ? 101 LYS A C   1 
ATOM 245  O O   . LYS A 1 101 ? 215.695 274.689 359.203 1.00 118.80 ? 101 LYS A O   1 
ATOM 246  C CB  . LYS A 1 101 ? 213.914 273.438 361.503 1.00 118.75 ? 101 LYS A CB  1 
ATOM 247  C CG  . LYS A 1 101 ? 212.986 274.052 360.468 1.00 119.53 ? 101 LYS A CG  1 
ATOM 248  C CD  . LYS A 1 101 ? 211.567 273.532 360.627 1.00 117.26 ? 101 LYS A CD  1 
ATOM 249  C CE  . LYS A 1 101 ? 210.656 274.059 359.534 1.00 117.55 ? 101 LYS A CE  1 
ATOM 250  N NZ  . LYS A 1 101 ? 209.281 273.497 359.635 1.00 117.25 ? 101 LYS A NZ  1 
ATOM 251  N N   . ASP A 1 102 ? 216.680 272.757 359.833 1.00 115.56 ? 102 ASP A N   1 
ATOM 252  C CA  . ASP A 1 102 ? 217.337 272.547 358.553 1.00 113.17 ? 102 ASP A CA  1 
ATOM 253  C C   . ASP A 1 102 ? 216.298 272.337 357.453 1.00 111.64 ? 102 ASP A C   1 
ATOM 254  O O   . ASP A 1 102 ? 215.087 272.326 357.691 1.00 112.06 ? 102 ASP A O   1 
ATOM 255  C CB  . ASP A 1 102 ? 218.289 271.358 358.641 1.00 111.54 ? 102 ASP A CB  1 
ATOM 256  C CG  . ASP A 1 102 ? 219.454 271.613 359.576 1.00 111.46 ? 102 ASP A CG  1 
ATOM 257  O OD1 . ASP A 1 102 ? 219.504 272.707 360.178 1.00 111.07 ? 102 ASP A OD1 1 
ATOM 258  O OD2 . ASP A 1 102 ? 220.320 270.723 359.706 1.00 109.32 ? 102 ASP A OD2 1 
ATOM 259  N N   . LYS A 1 103 ? 216.784 272.173 356.223 1.00 95.47  ? 103 LYS A N   1 
ATOM 260  C CA  . LYS A 1 103 ? 215.893 272.002 355.085 1.00 95.37  ? 103 LYS A CA  1 
ATOM 261  C C   . LYS A 1 103 ? 214.944 270.838 355.327 1.00 90.72  ? 103 LYS A C   1 
ATOM 262  O O   . LYS A 1 103 ? 215.346 269.776 355.806 1.00 89.26  ? 103 LYS A O   1 
ATOM 263  C CB  . LYS A 1 103 ? 216.694 271.746 353.807 1.00 94.19  ? 103 LYS A CB  1 
ATOM 264  C CG  . LYS A 1 103 ? 217.668 272.842 353.413 1.00 92.07  ? 103 LYS A CG  1 
ATOM 265  C CD  . LYS A 1 103 ? 218.311 272.513 352.075 1.00 91.29  ? 103 LYS A CD  1 
ATOM 266  C CE  . LYS A 1 103 ? 219.416 273.487 351.714 1.00 91.98  ? 103 LYS A CE  1 
ATOM 267  N NZ  . LYS A 1 103 ? 220.170 273.026 350.514 1.00 89.65  ? 103 LYS A NZ  1 
ATOM 268  N N   . LEU A 1 104 ? 213.674 271.049 354.996 1.00 93.47  ? 104 LEU A N   1 
ATOM 269  C CA  . LEU A 1 104 ? 212.677 269.986 355.053 1.00 96.32  ? 104 LEU A CA  1 
ATOM 270  C C   . LEU A 1 104 ? 212.518 269.367 353.666 1.00 95.16  ? 104 LEU A C   1 
ATOM 271  O O   . LEU A 1 104 ? 211.500 269.514 352.991 1.00 97.32  ? 104 LEU A O   1 
ATOM 272  C CB  . LEU A 1 104 ? 211.351 270.524 355.582 1.00 95.62  ? 104 LEU A CB  1 
ATOM 273  C CG  . LEU A 1 104 ? 211.169 270.465 357.097 1.00 94.91  ? 104 LEU A CG  1 
ATOM 274  C CD1 . LEU A 1 104 ? 212.270 271.233 357.804 1.00 95.89  ? 104 LEU A CD1 1 
ATOM 275  C CD2 . LEU A 1 104 ? 209.800 271.001 357.481 1.00 92.66  ? 104 LEU A CD2 1 
ATOM 276  N N   . PHE A 1 105 ? 213.567 268.670 353.242 1.00 71.77  ? 105 PHE A N   1 
ATOM 277  C CA  . PHE A 1 105 ? 213.472 267.884 352.024 1.00 68.56  ? 105 PHE A CA  1 
ATOM 278  C C   . PHE A 1 105 ? 212.318 266.904 352.160 1.00 71.52  ? 105 PHE A C   1 
ATOM 279  O O   . PHE A 1 105 ? 212.180 266.231 353.184 1.00 75.34  ? 105 PHE A O   1 
ATOM 280  C CB  . PHE A 1 105 ? 214.779 267.136 351.770 1.00 69.27  ? 105 PHE A CB  1 
ATOM 281  C CG  . PHE A 1 105 ? 215.049 266.045 352.760 1.00 70.85  ? 105 PHE A CG  1 
ATOM 282  C CD1 . PHE A 1 105 ? 215.561 266.339 354.011 1.00 73.03  ? 105 PHE A CD1 1 
ATOM 283  C CD2 . PHE A 1 105 ? 214.785 264.726 352.445 1.00 73.59  ? 105 PHE A CD2 1 
ATOM 284  C CE1 . PHE A 1 105 ? 215.806 265.338 354.924 1.00 75.64  ? 105 PHE A CE1 1 
ATOM 285  C CE2 . PHE A 1 105 ? 215.027 263.722 353.356 1.00 75.09  ? 105 PHE A CE2 1 
ATOM 286  C CZ  . PHE A 1 105 ? 215.538 264.029 354.596 1.00 74.96  ? 105 PHE A CZ  1 
ATOM 287  N N   . ALA A 1 106 ? 211.478 266.833 351.135 1.00 68.91  ? 106 ALA A N   1 
ATOM 288  C CA  . ALA A 1 106 ? 210.292 265.992 351.168 1.00 69.59  ? 106 ALA A CA  1 
ATOM 289  C C   . ALA A 1 106 ? 210.553 264.739 350.349 1.00 67.42  ? 106 ALA A C   1 
ATOM 290  O O   . ALA A 1 106 ? 210.879 264.828 349.163 1.00 66.92  ? 106 ALA A O   1 
ATOM 291  C CB  . ALA A 1 106 ? 209.075 266.742 350.632 1.00 66.91  ? 106 ALA A CB  1 
ATOM 292  N N   . VAL A 1 107 ? 210.406 263.579 350.980 1.00 54.82  ? 107 VAL A N   1 
ATOM 293  C CA  . VAL A 1 107 ? 210.624 262.289 350.339 1.00 54.22  ? 107 VAL A CA  1 
ATOM 294  C C   . VAL A 1 107 ? 209.310 261.523 350.369 1.00 55.47  ? 107 VAL A C   1 
ATOM 295  O O   . VAL A 1 107 ? 208.684 261.397 351.427 1.00 58.55  ? 107 VAL A O   1 
ATOM 296  C CB  . VAL A 1 107 ? 211.744 261.492 351.032 1.00 60.48  ? 107 VAL A CB  1 
ATOM 297  C CG1 . VAL A 1 107 ? 211.366 261.170 352.469 1.00 62.67  ? 107 VAL A CG1 1 
ATOM 298  C CG2 . VAL A 1 107 ? 212.049 260.224 350.259 1.00 57.68  ? 107 VAL A CG2 1 
ATOM 299  N N   . TRP A 1 108 ? 208.891 261.026 349.209 1.00 46.29  ? 108 TRP A N   1 
ATOM 300  C CA  . TRP A 1 108 ? 207.621 260.327 349.084 1.00 49.95  ? 108 TRP A CA  1 
ATOM 301  C C   . TRP A 1 108 ? 207.808 259.118 348.185 1.00 52.89  ? 108 TRP A C   1 
ATOM 302  O O   . TRP A 1 108 ? 208.275 259.253 347.052 1.00 57.36  ? 108 TRP A O   1 
ATOM 303  C CB  . TRP A 1 108 ? 206.542 261.257 348.520 1.00 47.09  ? 108 TRP A CB  1 
ATOM 304  C CG  . TRP A 1 108 ? 205.278 260.561 348.131 1.00 52.14  ? 108 TRP A CG  1 
ATOM 305  C CD1 . TRP A 1 108 ? 204.319 260.078 348.968 1.00 58.58  ? 108 TRP A CD1 1 
ATOM 306  C CD2 . TRP A 1 108 ? 204.830 260.280 346.802 1.00 53.21  ? 108 TRP A CD2 1 
ATOM 307  N NE1 . TRP A 1 108 ? 203.303 259.508 348.242 1.00 59.49  ? 108 TRP A NE1 1 
ATOM 308  C CE2 . TRP A 1 108 ? 203.594 259.621 346.909 1.00 59.24  ? 108 TRP A CE2 1 
ATOM 309  C CE3 . TRP A 1 108 ? 205.356 260.521 345.531 1.00 51.17  ? 108 TRP A CE3 1 
ATOM 310  C CZ2 . TRP A 1 108 ? 202.878 259.199 345.797 1.00 59.67  ? 108 TRP A CZ2 1 
ATOM 311  C CZ3 . TRP A 1 108 ? 204.643 260.103 344.429 1.00 50.72  ? 108 TRP A CZ3 1 
ATOM 312  C CH2 . TRP A 1 108 ? 203.418 259.450 344.568 1.00 54.34  ? 108 TRP A CH2 1 
ATOM 313  N N   . LYS A 1 109 ? 207.445 257.942 348.688 1.00 53.65  ? 109 LYS A N   1 
ATOM 314  C CA  . LYS A 1 109 ? 207.576 256.712 347.920 1.00 53.20  ? 109 LYS A CA  1 
ATOM 315  C C   . LYS A 1 109 ? 206.401 256.588 346.962 1.00 51.18  ? 109 LYS A C   1 
ATOM 316  O O   . LYS A 1 109 ? 205.243 256.604 347.391 1.00 55.88  ? 109 LYS A O   1 
ATOM 317  C CB  . LYS A 1 109 ? 207.636 255.506 348.850 1.00 53.94  ? 109 LYS A CB  1 
ATOM 318  C CG  . LYS A 1 109 ? 207.832 254.191 348.124 1.00 54.33  ? 109 LYS A CG  1 
ATOM 319  C CD  . LYS A 1 109 ? 207.782 253.016 349.076 1.00 57.62  ? 109 LYS A CD  1 
ATOM 320  C CE  . LYS A 1 109 ? 207.900 251.702 348.327 1.00 60.29  ? 109 LYS A CE  1 
ATOM 321  N NZ  . LYS A 1 109 ? 206.825 251.528 347.312 1.00 55.84  ? 109 LYS A NZ  1 
ATOM 322  N N   . ILE A 1 110 ? 206.695 256.452 345.671 1.00 48.30  ? 110 ILE A N   1 
ATOM 323  C CA  . ILE A 1 110 ? 205.634 256.423 344.672 1.00 51.46  ? 110 ILE A CA  1 
ATOM 324  C C   . ILE A 1 110 ? 204.739 255.223 344.932 1.00 59.31  ? 110 ILE A C   1 
ATOM 325  O O   . ILE A 1 110 ? 205.175 254.069 344.837 1.00 60.31  ? 110 ILE A O   1 
ATOM 326  C CB  . ILE A 1 110 ? 206.219 256.388 343.260 1.00 51.21  ? 110 ILE A CB  1 
ATOM 327  C CG1 . ILE A 1 110 ? 206.987 257.677 342.979 1.00 49.53  ? 110 ILE A CG1 1 
ATOM 328  C CG2 . ILE A 1 110 ? 205.110 256.199 342.236 1.00 50.35  ? 110 ILE A CG2 1 
ATOM 329  C CD1 . ILE A 1 110 ? 207.750 257.659 341.679 1.00 52.56  ? 110 ILE A CD1 1 
ATOM 330  N N   . THR A 1 111 ? 203.478 255.491 345.257 1.00 61.16  ? 111 THR A N   1 
ATOM 331  C CA  . THR A 1 111 ? 202.500 254.443 345.495 1.00 62.34  ? 111 THR A CA  1 
ATOM 332  C C   . THR A 1 111 ? 201.118 254.991 345.180 1.00 59.15  ? 111 THR A C   1 
ATOM 333  O O   . THR A 1 111 ? 200.790 256.117 345.561 1.00 55.43  ? 111 THR A O   1 
ATOM 334  C CB  . THR A 1 111 ? 202.551 253.942 346.941 1.00 66.51  ? 111 THR A CB  1 
ATOM 335  O OG1 . THR A 1 111 ? 201.652 252.839 347.097 1.00 69.39  ? 111 THR A OG1 1 
ATOM 336  C CG2 . THR A 1 111 ? 202.161 255.049 347.907 1.00 63.00  ? 111 THR A CG2 1 
ATOM 337  N N   . TYR A 1 112 ? 200.315 254.191 344.485 1.00 55.10  ? 112 TYR A N   1 
ATOM 338  C CA  . TYR A 1 112 ? 198.955 254.576 344.137 1.00 55.67  ? 112 TYR A CA  1 
ATOM 339  C C   . TYR A 1 112 ? 197.956 254.263 345.239 1.00 59.27  ? 112 TYR A C   1 
ATOM 340  O O   . TYR A 1 112 ? 196.769 254.556 345.077 1.00 65.04  ? 112 TYR A O   1 
ATOM 341  C CB  . TYR A 1 112 ? 198.519 253.878 342.844 1.00 53.20  ? 112 TYR A CB  1 
ATOM 342  C CG  . TYR A 1 112 ? 198.438 252.371 342.945 1.00 54.57  ? 112 TYR A CG  1 
ATOM 343  C CD1 . TYR A 1 112 ? 197.396 251.756 343.621 1.00 56.13  ? 112 TYR A CD1 1 
ATOM 344  C CD2 . TYR A 1 112 ? 199.393 251.564 342.351 1.00 60.05  ? 112 TYR A CD2 1 
ATOM 345  C CE1 . TYR A 1 112 ? 197.317 250.387 343.716 1.00 58.08  ? 112 TYR A CE1 1 
ATOM 346  C CE2 . TYR A 1 112 ? 199.319 250.190 342.439 1.00 62.89  ? 112 TYR A CE2 1 
ATOM 347  C CZ  . TYR A 1 112 ? 198.277 249.609 343.124 1.00 58.29  ? 112 TYR A CZ  1 
ATOM 348  O OH  . TYR A 1 112 ? 198.192 248.241 343.218 1.00 54.60  ? 112 TYR A OH  1 
ATOM 349  N N   . LYS A 1 113 ? 198.399 253.676 346.347 1.00 64.22  ? 113 LYS A N   1 
ATOM 350  C CA  . LYS A 1 113 ? 197.504 253.217 347.398 1.00 68.64  ? 113 LYS A CA  1 
ATOM 351  C C   . LYS A 1 113 ? 197.142 254.317 348.386 1.00 67.52  ? 113 LYS A C   1 
ATOM 352  O O   . LYS A 1 113 ? 196.722 254.014 349.508 1.00 69.66  ? 113 LYS A O   1 
ATOM 353  C CB  . LYS A 1 113 ? 198.129 252.031 348.134 1.00 68.35  ? 113 LYS A CB  1 
ATOM 354  C CG  . LYS A 1 113 ? 198.524 250.892 347.209 1.00 67.78  ? 113 LYS A CG  1 
ATOM 355  C CD  . LYS A 1 113 ? 198.538 249.559 347.932 1.00 70.95  ? 113 LYS A CD  1 
ATOM 356  C CE  . LYS A 1 113 ? 198.818 248.417 346.970 1.00 74.47  ? 113 LYS A CE  1 
ATOM 357  N NZ  . LYS A 1 113 ? 198.620 247.085 347.604 1.00 75.62  ? 113 LYS A NZ  1 
ATOM 358  N N   . ASP A 1 114 ? 197.300 255.582 348.001 1.00 72.95  ? 114 ASP A N   1 
ATOM 359  C CA  . ASP A 1 114 ? 196.845 256.701 348.811 1.00 71.88  ? 114 ASP A CA  1 
ATOM 360  C C   . ASP A 1 114 ? 195.745 257.515 348.152 1.00 73.10  ? 114 ASP A C   1 
ATOM 361  O O   . ASP A 1 114 ? 195.087 258.299 348.845 1.00 74.59  ? 114 ASP A O   1 
ATOM 362  C CB  . ASP A 1 114 ? 198.016 257.637 349.145 1.00 78.12  ? 114 ASP A CB  1 
ATOM 363  C CG  . ASP A 1 114 ? 199.113 256.942 349.925 1.00 83.60  ? 114 ASP A CG  1 
ATOM 364  O OD1 . ASP A 1 114 ? 199.085 255.696 350.013 1.00 80.39  ? 114 ASP A OD1 1 
ATOM 365  O OD2 . ASP A 1 114 ? 200.001 257.641 350.456 1.00 83.77  ? 114 ASP A OD2 1 
ATOM 366  N N   . THR A 1 115 ? 195.527 257.358 346.850 1.00 67.32  ? 115 THR A N   1 
ATOM 367  C CA  . THR A 1 115 ? 194.435 258.013 346.144 1.00 67.14  ? 115 THR A CA  1 
ATOM 368  C C   . THR A 1 115 ? 193.314 257.005 345.937 1.00 67.23  ? 115 THR A C   1 
ATOM 369  O O   . THR A 1 115 ? 193.529 255.944 345.342 1.00 65.11  ? 115 THR A O   1 
ATOM 370  C CB  . THR A 1 115 ? 194.901 258.565 344.800 1.00 63.25  ? 115 THR A CB  1 
ATOM 371  O OG1 . THR A 1 115 ? 195.335 257.487 343.964 1.00 55.11  ? 115 THR A OG1 1 
ATOM 372  C CG2 . THR A 1 115 ? 196.039 259.532 344.998 1.00 66.96  ? 115 THR A CG2 1 
ATOM 373  N N   . VAL A 1 116 ? 192.120 257.341 346.420 1.00 56.82  ? 116 VAL A N   1 
ATOM 374  C CA  . VAL A 1 116 ? 190.998 256.416 346.314 1.00 51.56  ? 116 VAL A CA  1 
ATOM 375  C C   . VAL A 1 116 ? 190.642 256.172 344.856 1.00 54.06  ? 116 VAL A C   1 
ATOM 376  O O   . VAL A 1 116 ? 190.376 255.035 344.451 1.00 58.86  ? 116 VAL A O   1 
ATOM 377  C CB  . VAL A 1 116 ? 189.795 256.950 347.108 1.00 57.17  ? 116 VAL A CB  1 
ATOM 378  C CG1 . VAL A 1 116 ? 188.606 256.021 346.955 1.00 59.66  ? 116 VAL A CG1 1 
ATOM 379  C CG2 . VAL A 1 116 ? 190.170 257.110 348.567 1.00 56.86  ? 116 VAL A CG2 1 
ATOM 380  N N   . GLN A 1 117 ? 190.622 257.229 344.044 1.00 51.98  ? 117 GLN A N   1 
ATOM 381  C CA  . GLN A 1 117 ? 190.130 257.094 342.677 1.00 54.60  ? 117 GLN A CA  1 
ATOM 382  C C   . GLN A 1 117 ? 191.016 256.167 341.854 1.00 49.62  ? 117 GLN A C   1 
ATOM 383  O O   . GLN A 1 117 ? 190.531 255.207 341.243 1.00 61.32  ? 117 GLN A O   1 
ATOM 384  C CB  . GLN A 1 117 ? 190.035 258.469 342.023 1.00 59.24  ? 117 GLN A CB  1 
ATOM 385  C CG  . GLN A 1 117 ? 189.169 259.446 342.793 1.00 56.97  ? 117 GLN A CG  1 
ATOM 386  C CD  . GLN A 1 117 ? 188.649 260.570 341.928 1.00 61.26  ? 117 GLN A CD  1 
ATOM 387  O OE1 . GLN A 1 117 ? 188.864 260.587 340.717 1.00 65.89  ? 117 GLN A OE1 1 
ATOM 388  N NE2 . GLN A 1 117 ? 187.955 261.517 342.546 1.00 65.17  ? 117 GLN A NE2 1 
ATOM 389  N N   . LEU A 1 118 ? 192.323 256.433 341.831 1.00 38.45  ? 118 LEU A N   1 
ATOM 390  C CA  . LEU A 1 118 ? 193.219 255.616 341.020 1.00 41.52  ? 118 LEU A CA  1 
ATOM 391  C C   . LEU A 1 118 ? 193.295 254.191 341.548 1.00 53.62  ? 118 LEU A C   1 
ATOM 392  O O   . LEU A 1 118 ? 193.270 253.232 340.768 1.00 57.90  ? 118 LEU A O   1 
ATOM 393  C CB  . LEU A 1 118 ? 194.611 256.240 340.978 1.00 41.40  ? 118 LEU A CB  1 
ATOM 394  C CG  . LEU A 1 118 ? 195.667 255.435 340.222 1.00 43.21  ? 118 LEU A CG  1 
ATOM 395  C CD1 . LEU A 1 118 ? 195.197 255.109 338.822 1.00 46.40  ? 118 LEU A CD1 1 
ATOM 396  C CD2 . LEU A 1 118 ? 196.972 256.199 340.178 1.00 47.66  ? 118 LEU A CD2 1 
ATOM 397  N N   . ARG A 1 119 ? 193.393 254.030 342.867 1.00 59.90  ? 119 ARG A N   1 
ATOM 398  C CA  . ARG A 1 119 ? 193.438 252.689 343.435 1.00 48.69  ? 119 ARG A CA  1 
ATOM 399  C C   . ARG A 1 119 ? 192.197 251.903 343.049 1.00 49.23  ? 119 ARG A C   1 
ATOM 400  O O   . ARG A 1 119 ? 192.291 250.780 342.544 1.00 56.14  ? 119 ARG A O   1 
ATOM 401  C CB  . ARG A 1 119 ? 193.572 252.763 344.954 1.00 49.81  ? 119 ARG A CB  1 
ATOM 402  C CG  . ARG A 1 119 ? 193.788 251.411 345.604 1.00 53.63  ? 119 ARG A CG  1 
ATOM 403  C CD  . ARG A 1 119 ? 193.853 251.518 347.112 1.00 57.23  ? 119 ARG A CD  1 
ATOM 404  N NE  . ARG A 1 119 ? 194.250 250.257 347.724 1.00 57.88  ? 119 ARG A NE  1 
ATOM 405  C CZ  . ARG A 1 119 ? 194.293 250.039 349.031 1.00 62.04  ? 119 ARG A CZ  1 
ATOM 406  N NH1 . ARG A 1 119 ? 193.952 250.975 349.900 1.00 63.87  ? 119 ARG A NH1 1 
ATOM 407  N NH2 . ARG A 1 119 ? 194.690 248.851 349.477 1.00 59.11  ? 119 ARG A NH2 1 
ATOM 408  N N   . ARG A 1 120 ? 191.018 252.490 343.257 1.00 51.29  ? 120 ARG A N   1 
ATOM 409  C CA  . ARG A 1 120 ? 189.786 251.780 342.946 1.00 49.79  ? 120 ARG A CA  1 
ATOM 410  C C   . ARG A 1 120 ? 189.719 251.429 341.469 1.00 45.99  ? 120 ARG A C   1 
ATOM 411  O O   . ARG A 1 120 ? 189.323 250.317 341.108 1.00 47.94  ? 120 ARG A O   1 
ATOM 412  C CB  . ARG A 1 120 ? 188.576 252.616 343.350 1.00 43.92  ? 120 ARG A CB  1 
ATOM 413  C CG  . ARG A 1 120 ? 187.276 251.842 343.297 1.00 51.34  ? 120 ARG A CG  1 
ATOM 414  C CD  . ARG A 1 120 ? 186.099 252.684 343.735 1.00 61.85  ? 120 ARG A CD  1 
ATOM 415  N NE  . ARG A 1 120 ? 184.919 251.866 343.982 1.00 58.69  ? 120 ARG A NE  1 
ATOM 416  C CZ  . ARG A 1 120 ? 184.125 251.390 343.034 1.00 55.84  ? 120 ARG A CZ  1 
ATOM 417  N NH1 . ARG A 1 120 ? 184.354 251.629 341.754 1.00 60.66  ? 120 ARG A NH1 1 
ATOM 418  N NH2 . ARG A 1 120 ? 183.074 250.653 343.378 1.00 56.78  ? 120 ARG A NH2 1 
ATOM 419  N N   . LYS A 1 121 ? 190.103 252.361 340.595 1.00 41.70  ? 121 LYS A N   1 
ATOM 420  C CA  . LYS A 1 121 ? 190.081 252.061 339.170 1.00 38.22  ? 121 LYS A CA  1 
ATOM 421  C C   . LYS A 1 121 ? 191.064 250.954 338.820 1.00 49.54  ? 121 LYS A C   1 
ATOM 422  O O   . LYS A 1 121 ? 190.847 250.218 337.852 1.00 52.35  ? 121 LYS A O   1 
ATOM 423  C CB  . LYS A 1 121 ? 190.388 253.321 338.364 1.00 38.56  ? 121 LYS A CB  1 
ATOM 424  C CG  . LYS A 1 121 ? 189.345 254.409 338.509 1.00 44.25  ? 121 LYS A CG  1 
ATOM 425  C CD  . LYS A 1 121 ? 189.906 255.777 338.166 1.00 43.44  ? 121 LYS A CD  1 
ATOM 426  C CE  . LYS A 1 121 ? 190.435 255.836 336.747 1.00 46.99  ? 121 LYS A CE  1 
ATOM 427  N NZ  . LYS A 1 121 ? 189.411 255.429 335.754 1.00 45.30  ? 121 LYS A NZ  1 
ATOM 428  N N   . LEU A 1 122 ? 192.146 250.817 339.586 1.00 49.42  ? 122 LEU A N   1 
ATOM 429  C CA  . LEU A 1 122 ? 193.133 249.780 339.312 1.00 44.51  ? 122 LEU A CA  1 
ATOM 430  C C   . LEU A 1 122 ? 192.786 248.437 339.934 1.00 49.73  ? 122 LEU A C   1 
ATOM 431  O O   . LEU A 1 122 ? 193.375 247.424 339.545 1.00 46.63  ? 122 LEU A O   1 
ATOM 432  C CB  . LEU A 1 122 ? 194.514 250.208 339.814 1.00 35.80  ? 122 LEU A CB  1 
ATOM 433  C CG  . LEU A 1 122 ? 195.361 251.038 338.852 1.00 42.41  ? 122 LEU A CG  1 
ATOM 434  C CD1 . LEU A 1 122 ? 196.651 251.448 339.529 1.00 53.49  ? 122 LEU A CD1 1 
ATOM 435  C CD2 . LEU A 1 122 ? 195.654 250.270 337.578 1.00 43.83  ? 122 LEU A CD2 1 
ATOM 436  N N   . GLU A 1 123 ? 191.853 248.397 340.877 1.00 59.55  ? 123 GLU A N   1 
ATOM 437  C CA  . GLU A 1 123 ? 191.475 247.150 341.524 1.00 52.30  ? 123 GLU A CA  1 
ATOM 438  C C   . GLU A 1 123 ? 190.393 246.401 340.764 1.00 52.09  ? 123 GLU A C   1 
ATOM 439  O O   . GLU A 1 123 ? 189.936 245.357 341.234 1.00 59.09  ? 123 GLU A O   1 
ATOM 440  C CB  . GLU A 1 123 ? 191.014 247.417 342.956 1.00 57.17  ? 123 GLU A CB  1 
ATOM 441  C CG  . GLU A 1 123 ? 192.150 247.778 343.889 1.00 58.48  ? 123 GLU A CG  1 
ATOM 442  C CD  . GLU A 1 123 ? 191.689 247.987 345.311 1.00 65.68  ? 123 GLU A CD  1 
ATOM 443  O OE1 . GLU A 1 123 ? 190.463 248.071 345.534 1.00 63.47  ? 123 GLU A OE1 1 
ATOM 444  O OE2 . GLU A 1 123 ? 192.554 248.067 346.207 1.00 63.30  ? 123 GLU A OE2 1 
ATOM 445  N N   . PHE A 1 124 ? 189.966 246.913 339.612 1.00 45.15  ? 124 PHE A N   1 
ATOM 446  C CA  . PHE A 1 124 ? 189.118 246.140 338.717 1.00 45.32  ? 124 PHE A CA  1 
ATOM 447  C C   . PHE A 1 124 ? 189.881 245.019 338.029 1.00 50.01  ? 124 PHE A C   1 
ATOM 448  O O   . PHE A 1 124 ? 189.253 244.177 337.382 1.00 52.62  ? 124 PHE A O   1 
ATOM 449  C CB  . PHE A 1 124 ? 188.503 247.048 337.651 1.00 41.71  ? 124 PHE A CB  1 
ATOM 450  C CG  . PHE A 1 124 ? 187.413 247.944 338.161 1.00 43.24  ? 124 PHE A CG  1 
ATOM 451  C CD1 . PHE A 1 124 ? 187.631 248.789 339.229 1.00 54.73  ? 124 PHE A CD1 1 
ATOM 452  C CD2 . PHE A 1 124 ? 186.176 247.958 337.550 1.00 43.74  ? 124 PHE A CD2 1 
ATOM 453  C CE1 . PHE A 1 124 ? 186.633 249.614 339.689 1.00 49.47  ? 124 PHE A CE1 1 
ATOM 454  C CE2 . PHE A 1 124 ? 185.177 248.785 338.007 1.00 48.21  ? 124 PHE A CE2 1 
ATOM 455  C CZ  . PHE A 1 124 ? 185.409 249.615 339.075 1.00 47.15  ? 124 PHE A CZ  1 
ATOM 456  N N   . PHE A 1 125 ? 191.207 244.993 338.145 1.00 47.03  ? 125 PHE A N   1 
ATOM 457  C CA  . PHE A 1 125 ? 192.034 244.037 337.426 1.00 42.65  ? 125 PHE A CA  1 
ATOM 458  C C   . PHE A 1 125 ? 193.138 243.536 338.345 1.00 40.25  ? 125 PHE A C   1 
ATOM 459  O O   . PHE A 1 125 ? 193.501 244.188 339.326 1.00 43.10  ? 125 PHE A O   1 
ATOM 460  C CB  . PHE A 1 125 ? 192.630 244.664 336.166 1.00 38.88  ? 125 PHE A CB  1 
ATOM 461  C CG  . PHE A 1 125 ? 191.611 245.316 335.280 1.00 38.04  ? 125 PHE A CG  1 
ATOM 462  C CD1 . PHE A 1 125 ? 191.169 246.596 335.542 1.00 41.67  ? 125 PHE A CD1 1 
ATOM 463  C CD2 . PHE A 1 125 ? 191.098 244.650 334.186 1.00 34.56  ? 125 PHE A CD2 1 
ATOM 464  C CE1 . PHE A 1 125 ? 190.235 247.194 334.731 1.00 48.65  ? 125 PHE A CE1 1 
ATOM 465  C CE2 . PHE A 1 125 ? 190.165 245.245 333.373 1.00 33.70  ? 125 PHE A CE2 1 
ATOM 466  C CZ  . PHE A 1 125 ? 189.734 246.517 333.645 1.00 47.27  ? 125 PHE A CZ  1 
ATOM 467  N N   . THR A 1 126 ? 193.671 242.361 338.015 1.00 41.85  ? 126 THR A N   1 
ATOM 468  C CA  . THR A 1 126 ? 194.682 241.722 338.848 1.00 48.23  ? 126 THR A CA  1 
ATOM 469  C C   . THR A 1 126 ? 196.088 242.197 338.507 1.00 49.60  ? 126 THR A C   1 
ATOM 470  O O   . THR A 1 126 ? 196.839 242.606 339.397 1.00 49.18  ? 126 THR A O   1 
ATOM 471  C CB  . THR A 1 126 ? 194.607 240.199 338.701 1.00 43.16  ? 126 THR A CB  1 
ATOM 472  O OG1 . THR A 1 126 ? 193.244 239.767 338.787 1.00 39.72  ? 126 THR A OG1 1 
ATOM 473  C CG2 . THR A 1 126 ? 195.414 239.525 339.789 1.00 38.70  ? 126 THR A CG2 1 
ATOM 474  N N   . TYR A 1 127 ? 196.458 242.150 337.230 1.00 42.88  ? 127 TYR A N   1 
ATOM 475  C CA  . TYR A 1 127 ? 197.794 242.504 336.778 1.00 32.68  ? 127 TYR A CA  1 
ATOM 476  C C   . TYR A 1 127 ? 197.711 243.677 335.817 1.00 36.18  ? 127 TYR A C   1 
ATOM 477  O O   . TYR A 1 127 ? 196.762 243.781 335.036 1.00 46.71  ? 127 TYR A O   1 
ATOM 478  C CB  . TYR A 1 127 ? 198.473 241.323 336.088 1.00 39.67  ? 127 TYR A CB  1 
ATOM 479  C CG  . TYR A 1 127 ? 198.501 240.064 336.920 1.00 46.38  ? 127 TYR A CG  1 
ATOM 480  C CD1 . TYR A 1 127 ? 199.296 239.977 338.052 1.00 47.12  ? 127 TYR A CD1 1 
ATOM 481  C CD2 . TYR A 1 127 ? 197.739 238.961 336.568 1.00 38.19  ? 127 TYR A CD2 1 
ATOM 482  C CE1 . TYR A 1 127 ? 199.326 238.831 338.814 1.00 42.78  ? 127 TYR A CE1 1 
ATOM 483  C CE2 . TYR A 1 127 ? 197.762 237.812 337.324 1.00 39.52  ? 127 TYR A CE2 1 
ATOM 484  C CZ  . TYR A 1 127 ? 198.557 237.752 338.447 1.00 46.49  ? 127 TYR A CZ  1 
ATOM 485  O OH  . TYR A 1 127 ? 198.588 236.608 339.204 1.00 49.46  ? 127 TYR A OH  1 
ATOM 486  N N   . SER A 1 128 ? 198.712 244.553 335.867 1.00 46.77  ? 128 SER A N   1 
ATOM 487  C CA  . SER A 1 128 ? 198.724 245.737 335.024 1.00 46.42  ? 128 SER A CA  1 
ATOM 488  C C   . SER A 1 128 ? 200.153 246.089 334.636 1.00 42.69  ? 128 SER A C   1 
ATOM 489  O O   . SER A 1 128 ? 201.106 245.768 335.348 1.00 48.41  ? 128 SER A O   1 
ATOM 490  C CB  . SER A 1 128 ? 198.064 246.921 335.733 1.00 50.28  ? 128 SER A CB  1 
ATOM 491  O OG  . SER A 1 128 ? 198.652 247.138 337.001 1.00 51.75  ? 128 SER A OG  1 
ATOM 492  N N   . ARG A 1 129 ? 200.281 246.751 333.489 1.00 38.78  ? 129 ARG A N   1 
ATOM 493  C CA  . ARG A 1 129 ? 201.550 247.269 332.979 1.00 38.80  ? 129 ARG A CA  1 
ATOM 494  C C   . ARG A 1 129 ? 201.293 248.704 332.541 1.00 50.02  ? 129 ARG A C   1 
ATOM 495  O O   . ARG A 1 129 ? 200.804 248.931 331.430 1.00 59.60  ? 129 ARG A O   1 
ATOM 496  C CB  . ARG A 1 129 ? 202.068 246.441 331.810 1.00 42.94  ? 129 ARG A CB  1 
ATOM 497  C CG  . ARG A 1 129 ? 203.066 245.372 332.172 1.00 50.61  ? 129 ARG A CG  1 
ATOM 498  C CD  . ARG A 1 129 ? 203.554 244.660 330.924 1.00 48.22  ? 129 ARG A CD  1 
ATOM 499  N NE  . ARG A 1 129 ? 204.327 245.542 330.057 1.00 46.89  ? 129 ARG A NE  1 
ATOM 500  C CZ  . ARG A 1 129 ? 205.602 245.369 329.733 1.00 45.65  ? 129 ARG A CZ  1 
ATOM 501  N NH1 . ARG A 1 129 ? 206.294 244.326 330.159 1.00 45.29  ? 129 ARG A NH1 1 
ATOM 502  N NH2 . ARG A 1 129 ? 206.199 246.265 328.954 1.00 49.20  ? 129 ARG A NH2 1 
ATOM 503  N N   . PHE A 1 130 ? 201.608 249.671 333.399 1.00 49.71  ? 130 PHE A N   1 
ATOM 504  C CA  . PHE A 1 130 ? 201.334 251.070 333.104 1.00 40.95  ? 130 PHE A CA  1 
ATOM 505  C C   . PHE A 1 130 ? 202.584 251.906 333.315 1.00 39.92  ? 130 PHE A C   1 
ATOM 506  O O   . PHE A 1 130 ? 203.263 251.776 334.337 1.00 46.50  ? 130 PHE A O   1 
ATOM 507  C CB  . PHE A 1 130 ? 200.184 251.605 333.963 1.00 44.29  ? 130 PHE A CB  1 
ATOM 508  C CG  . PHE A 1 130 ? 200.513 251.737 335.416 1.00 47.88  ? 130 PHE A CG  1 
ATOM 509  C CD1 . PHE A 1 130 ? 201.051 252.907 335.913 1.00 52.30  ? 130 PHE A CD1 1 
ATOM 510  C CD2 . PHE A 1 130 ? 200.260 250.702 336.291 1.00 43.86  ? 130 PHE A CD2 1 
ATOM 511  C CE1 . PHE A 1 130 ? 201.343 253.035 337.250 1.00 45.32  ? 130 PHE A CE1 1 
ATOM 512  C CE2 . PHE A 1 130 ? 200.551 250.826 337.628 1.00 47.79  ? 130 PHE A CE2 1 
ATOM 513  C CZ  . PHE A 1 130 ? 201.092 251.994 338.108 1.00 48.64  ? 130 PHE A CZ  1 
ATOM 514  N N   . ASP A 1 131 ? 202.871 252.765 332.345 1.00 56.31  ? 131 ASP A N   1 
ATOM 515  C CA  . ASP A 1 131 ? 203.979 253.702 332.410 1.00 54.22  ? 131 ASP A CA  1 
ATOM 516  C C   . ASP A 1 131 ? 203.500 255.013 333.019 1.00 57.22  ? 131 ASP A C   1 
ATOM 517  O O   . ASP A 1 131 ? 202.440 255.526 332.655 1.00 61.13  ? 131 ASP A O   1 
ATOM 518  C CB  . ASP A 1 131 ? 204.540 253.922 331.003 1.00 56.14  ? 131 ASP A CB  1 
ATOM 519  C CG  . ASP A 1 131 ? 205.530 255.062 330.926 1.00 66.14  ? 131 ASP A CG  1 
ATOM 520  O OD1 . ASP A 1 131 ? 205.792 255.717 331.952 1.00 70.92  ? 131 ASP A OD1 1 
ATOM 521  O OD2 . ASP A 1 131 ? 206.052 255.304 329.818 1.00 70.29  ? 131 ASP A OD2 1 
ATOM 522  N N   . MET A 1 132 ? 204.288 255.550 333.946 1.00 44.89  ? 132 MET A N   1 
ATOM 523  C CA  . MET A 1 132 ? 203.917 256.756 334.670 1.00 44.97  ? 132 MET A CA  1 
ATOM 524  C C   . MET A 1 132 ? 204.373 258.003 333.921 1.00 54.33  ? 132 MET A C   1 
ATOM 525  O O   . MET A 1 132 ? 205.296 257.967 333.106 1.00 64.16  ? 132 MET A O   1 
ATOM 526  C CB  . MET A 1 132 ? 204.520 256.751 336.072 1.00 44.34  ? 132 MET A CB  1 
ATOM 527  C CG  . MET A 1 132 ? 204.082 255.579 336.927 1.00 56.90  ? 132 MET A CG  1 
ATOM 528  S SD  . MET A 1 132 ? 204.549 255.769 338.657 1.00 85.65  ? 132 MET A SD  1 
ATOM 529  C CE  . MET A 1 132 ? 206.323 255.954 338.517 1.00 58.91  ? 132 MET A CE  1 
ATOM 530  N N   . GLU A 1 133 ? 203.696 259.114 334.201 1.00 43.01  ? 133 GLU A N   1 
ATOM 531  C CA  . GLU A 1 133 ? 203.965 260.391 333.545 1.00 46.86  ? 133 GLU A CA  1 
ATOM 532  C C   . GLU A 1 133 ? 203.940 261.520 334.570 1.00 51.15  ? 133 GLU A C   1 
ATOM 533  O O   . GLU A 1 133 ? 203.253 262.527 334.403 1.00 55.54  ? 133 GLU A O   1 
ATOM 534  C CB  . GLU A 1 133 ? 202.965 260.644 332.421 1.00 53.27  ? 133 GLU A CB  1 
ATOM 535  C CG  . GLU A 1 133 ? 203.295 261.850 331.563 1.00 56.24  ? 133 GLU A CG  1 
ATOM 536  C CD  . GLU A 1 133 ? 202.397 261.964 330.349 1.00 60.85  ? 133 GLU A CD  1 
ATOM 537  O OE1 . GLU A 1 133 ? 201.720 260.972 330.012 1.00 57.73  ? 133 GLU A OE1 1 
ATOM 538  O OE2 . GLU A 1 133 ? 202.366 263.049 329.731 1.00 60.85  ? 133 GLU A OE2 1 
ATOM 539  N N   . LEU A 1 134 ? 204.685 261.346 335.659 1.00 45.29  ? 134 LEU A N   1 
ATOM 540  C CA  . LEU A 1 134 ? 204.662 262.303 336.758 1.00 46.17  ? 134 LEU A CA  1 
ATOM 541  C C   . LEU A 1 134 ? 204.781 263.735 336.251 1.00 51.90  ? 134 LEU A C   1 
ATOM 542  O O   . LEU A 1 134 ? 205.411 264.005 335.226 1.00 56.98  ? 134 LEU A O   1 
ATOM 543  C CB  . LEU A 1 134 ? 205.800 262.008 337.732 1.00 44.07  ? 134 LEU A CB  1 
ATOM 544  C CG  . LEU A 1 134 ? 205.798 260.625 338.376 1.00 50.04  ? 134 LEU A CG  1 
ATOM 545  C CD1 . LEU A 1 134 ? 207.083 260.413 339.145 1.00 55.10  ? 134 LEU A CD1 1 
ATOM 546  C CD2 . LEU A 1 134 ? 204.603 260.470 339.288 1.00 53.66  ? 134 LEU A CD2 1 
ATOM 547  N N   . THR A 1 135 ? 204.157 264.655 336.984 1.00 58.00  ? 135 THR A N   1 
ATOM 548  C CA  . THR A 1 135 ? 204.241 266.084 336.716 1.00 53.77  ? 135 THR A CA  1 
ATOM 549  C C   . THR A 1 135 ? 204.140 266.815 338.044 1.00 48.60  ? 135 THR A C   1 
ATOM 550  O O   . THR A 1 135 ? 203.429 266.368 338.944 1.00 56.67  ? 135 THR A O   1 
ATOM 551  C CB  . THR A 1 135 ? 203.135 266.551 335.770 1.00 46.66  ? 135 THR A CB  1 
ATOM 552  O OG1 . THR A 1 135 ? 203.339 265.979 334.474 1.00 52.40  ? 135 THR A OG1 1 
ATOM 553  C CG2 . THR A 1 135 ? 203.132 268.060 335.660 1.00 46.28  ? 135 THR A CG2 1 
ATOM 554  N N   . PHE A 1 136 ? 204.849 267.930 338.171 1.00 43.63  ? 136 PHE A N   1 
ATOM 555  C CA  . PHE A 1 136 ? 204.985 268.617 339.448 1.00 47.82  ? 136 PHE A CA  1 
ATOM 556  C C   . PHE A 1 136 ? 204.548 270.064 339.313 1.00 59.77  ? 136 PHE A C   1 
ATOM 557  O O   . PHE A 1 136 ? 205.053 270.793 338.454 1.00 64.51  ? 136 PHE A O   1 
ATOM 558  C CB  . PHE A 1 136 ? 206.428 268.551 339.944 1.00 49.60  ? 136 PHE A CB  1 
ATOM 559  C CG  . PHE A 1 136 ? 206.976 267.162 340.007 1.00 55.46  ? 136 PHE A CG  1 
ATOM 560  C CD1 . PHE A 1 136 ? 207.478 266.553 338.872 1.00 52.15  ? 136 PHE A CD1 1 
ATOM 561  C CD2 . PHE A 1 136 ? 206.988 266.464 341.196 1.00 59.06  ? 136 PHE A CD2 1 
ATOM 562  C CE1 . PHE A 1 136 ? 207.980 265.277 338.923 1.00 52.70  ? 136 PHE A CE1 1 
ATOM 563  C CE2 . PHE A 1 136 ? 207.491 265.187 341.253 1.00 59.63  ? 136 PHE A CE2 1 
ATOM 564  C CZ  . PHE A 1 136 ? 207.988 264.593 340.114 1.00 55.68  ? 136 PHE A CZ  1 
ATOM 565  N N   . VAL A 1 137 ? 203.628 270.481 340.177 1.00 64.79  ? 137 VAL A N   1 
ATOM 566  C CA  . VAL A 1 137 ? 203.166 271.862 340.246 1.00 56.85  ? 137 VAL A CA  1 
ATOM 567  C C   . VAL A 1 137 ? 203.706 272.460 341.534 1.00 55.00  ? 137 VAL A C   1 
ATOM 568  O O   . VAL A 1 137 ? 203.366 271.999 342.630 1.00 61.83  ? 137 VAL A O   1 
ATOM 569  C CB  . VAL A 1 137 ? 201.635 271.948 340.192 1.00 51.38  ? 137 VAL A CB  1 
ATOM 570  C CG1 . VAL A 1 137 ? 201.177 273.352 340.518 1.00 57.35  ? 137 VAL A CG1 1 
ATOM 571  C CG2 . VAL A 1 137 ? 201.138 271.525 338.827 1.00 55.04  ? 137 VAL A CG2 1 
ATOM 572  N N   . VAL A 1 138 ? 204.541 273.482 341.406 1.00 59.27  ? 138 VAL A N   1 
ATOM 573  C CA  . VAL A 1 138 ? 205.272 274.048 342.532 1.00 63.81  ? 138 VAL A CA  1 
ATOM 574  C C   . VAL A 1 138 ? 204.637 275.371 342.924 1.00 68.82  ? 138 VAL A C   1 
ATOM 575  O O   . VAL A 1 138 ? 204.423 276.245 342.075 1.00 71.69  ? 138 VAL A O   1 
ATOM 576  C CB  . VAL A 1 138 ? 206.757 274.239 342.189 1.00 62.34  ? 138 VAL A CB  1 
ATOM 577  C CG1 . VAL A 1 138 ? 207.499 274.806 343.378 1.00 63.59  ? 138 VAL A CG1 1 
ATOM 578  C CG2 . VAL A 1 138 ? 207.370 272.924 341.750 1.00 60.90  ? 138 VAL A CG2 1 
ATOM 579  N N   . THR A 1 139 ? 204.340 275.520 344.211 1.00 70.88  ? 139 THR A N   1 
ATOM 580  C CA  . THR A 1 139 ? 203.818 276.760 344.759 1.00 68.66  ? 139 THR A CA  1 
ATOM 581  C C   . THR A 1 139 ? 204.563 277.058 346.049 1.00 68.91  ? 139 THR A C   1 
ATOM 582  O O   . THR A 1 139 ? 205.080 276.154 346.707 1.00 75.94  ? 139 THR A O   1 
ATOM 583  C CB  . THR A 1 139 ? 202.314 276.673 345.030 1.00 66.40  ? 139 THR A CB  1 
ATOM 584  O OG1 . THR A 1 139 ? 202.084 275.879 346.199 1.00 68.19  ? 139 THR A OG1 1 
ATOM 585  C CG2 . THR A 1 139 ? 201.598 276.042 343.850 1.00 66.59  ? 139 THR A CG2 1 
ATOM 586  N N   . ALA A 1 140 ? 204.619 278.337 346.409 1.00 68.21  ? 140 ALA A N   1 
ATOM 587  C CA  . ALA A 1 140 ? 205.334 278.742 347.609 1.00 71.22  ? 140 ALA A CA  1 
ATOM 588  C C   . ALA A 1 140 ? 204.726 280.021 348.157 1.00 74.08  ? 140 ALA A C   1 
ATOM 589  O O   . ALA A 1 140 ? 203.963 280.717 347.484 1.00 72.94  ? 140 ALA A O   1 
ATOM 590  C CB  . ALA A 1 140 ? 206.827 278.936 347.337 1.00 73.29  ? 140 ALA A CB  1 
ATOM 591  N N   . ASN A 1 141 ? 205.079 280.319 349.405 1.00 97.45  ? 141 ASN A N   1 
ATOM 592  C CA  . ASN A 1 141 ? 204.569 281.499 350.090 1.00 99.47  ? 141 ASN A CA  1 
ATOM 593  C C   . ASN A 1 141 ? 205.530 281.894 351.199 1.00 99.35  ? 141 ASN A C   1 
ATOM 594  O O   . ASN A 1 141 ? 206.124 281.026 351.852 1.00 100.50 ? 141 ASN A O   1 
ATOM 595  C CB  . ASN A 1 141 ? 203.178 281.235 350.670 1.00 99.15  ? 141 ASN A CB  1 
ATOM 596  C CG  . ASN A 1 141 ? 203.210 280.264 351.830 1.00 100.48 ? 141 ASN A CG  1 
ATOM 597  O OD1 . ASN A 1 141 ? 203.209 279.049 351.638 1.00 101.19 ? 141 ASN A OD1 1 
ATOM 598  N ND2 . ASN A 1 141 ? 203.238 280.797 353.046 1.00 99.73  ? 141 ASN A ND2 1 
ATOM 599  N N   . PHE A 1 142 ? 205.685 283.202 351.398 1.00 109.82 ? 142 PHE A N   1 
ATOM 600  C CA  . PHE A 1 142 ? 206.392 283.709 352.565 1.00 111.39 ? 142 PHE A CA  1 
ATOM 601  C C   . PHE A 1 142 ? 205.535 283.521 353.808 1.00 113.69 ? 142 PHE A C   1 
ATOM 602  O O   . PHE A 1 142 ? 204.319 283.728 353.774 1.00 112.30 ? 142 PHE A O   1 
ATOM 603  C CB  . PHE A 1 142 ? 206.729 285.189 352.383 1.00 113.10 ? 142 PHE A CB  1 
ATOM 604  C CG  . PHE A 1 142 ? 207.716 285.462 351.285 1.00 113.53 ? 142 PHE A CG  1 
ATOM 605  C CD1 . PHE A 1 142 ? 209.075 285.345 351.514 1.00 115.74 ? 142 PHE A CD1 1 
ATOM 606  C CD2 . PHE A 1 142 ? 207.287 285.852 350.029 1.00 112.30 ? 142 PHE A CD2 1 
ATOM 607  C CE1 . PHE A 1 142 ? 209.986 285.599 350.510 1.00 115.34 ? 142 PHE A CE1 1 
ATOM 608  C CE2 . PHE A 1 142 ? 208.196 286.110 349.021 1.00 112.48 ? 142 PHE A CE2 1 
ATOM 609  C CZ  . PHE A 1 142 ? 209.545 285.983 349.263 1.00 112.77 ? 142 PHE A CZ  1 
ATOM 610  N N   . THR A 1 143 ? 206.170 283.131 354.909 1.00 123.26 ? 143 THR A N   1 
ATOM 611  C CA  . THR A 1 143 ? 205.468 282.943 356.171 1.00 124.07 ? 143 THR A CA  1 
ATOM 612  C C   . THR A 1 143 ? 205.483 284.187 357.051 1.00 123.40 ? 143 THR A C   1 
ATOM 613  O O   . THR A 1 143 ? 204.832 284.191 358.102 1.00 122.35 ? 143 THR A O   1 
ATOM 614  C CB  . THR A 1 143 ? 206.081 281.761 356.937 1.00 123.13 ? 143 THR A CB  1 
ATOM 615  O OG1 . THR A 1 143 ? 206.051 280.589 356.113 1.00 121.32 ? 143 THR A OG1 1 
ATOM 616  C CG2 . THR A 1 143 ? 205.314 281.484 358.222 1.00 121.52 ? 143 THR A CG2 1 
ATOM 617  N N   . GLU A 1 144 ? 206.183 285.244 356.645 1.00 131.58 ? 144 GLU A N   1 
ATOM 618  C CA  . GLU A 1 144 ? 206.310 286.455 357.440 1.00 130.85 ? 144 GLU A CA  1 
ATOM 619  C C   . GLU A 1 144 ? 205.869 287.666 356.630 1.00 132.65 ? 144 GLU A C   1 
ATOM 620  O O   . GLU A 1 144 ? 205.912 287.669 355.397 1.00 132.77 ? 144 GLU A O   1 
ATOM 621  C CB  . GLU A 1 144 ? 207.752 286.651 357.921 1.00 130.89 ? 144 GLU A CB  1 
ATOM 622  C CG  . GLU A 1 144 ? 208.250 285.549 358.837 1.00 131.29 ? 144 GLU A CG  1 
ATOM 623  C CD  . GLU A 1 144 ? 209.662 285.794 359.327 1.00 132.59 ? 144 GLU A CD  1 
ATOM 624  O OE1 . GLU A 1 144 ? 210.286 286.778 358.878 1.00 133.03 ? 144 GLU A OE1 1 
ATOM 625  O OE2 . GLU A 1 144 ? 210.148 285.003 360.162 1.00 133.23 ? 144 GLU A OE2 1 
ATOM 626  N N   . THR A 1 145 ? 205.442 288.706 357.350 1.00 140.82 ? 145 THR A N   1 
ATOM 627  C CA  . THR A 1 145 ? 204.970 289.919 356.689 1.00 140.38 ? 145 THR A CA  1 
ATOM 628  C C   . THR A 1 145 ? 206.073 290.559 355.855 1.00 141.22 ? 145 THR A C   1 
ATOM 629  O O   . THR A 1 145 ? 205.832 290.991 354.722 1.00 138.50 ? 145 THR A O   1 
ATOM 630  C CB  . THR A 1 145 ? 204.446 290.911 357.727 1.00 139.49 ? 145 THR A CB  1 
ATOM 631  O OG1 . THR A 1 145 ? 205.477 291.201 358.679 1.00 141.83 ? 145 THR A OG1 1 
ATOM 632  C CG2 . THR A 1 145 ? 203.235 290.340 358.450 1.00 138.05 ? 145 THR A CG2 1 
ATOM 633  N N   . ASN A 1 146 ? 207.286 290.634 356.397 1.00 139.91 ? 146 ASN A N   1 
ATOM 634  C CA  . ASN A 1 146 ? 208.401 291.183 355.638 1.00 137.33 ? 146 ASN A CA  1 
ATOM 635  C C   . ASN A 1 146 ? 208.648 290.336 354.397 1.00 137.19 ? 146 ASN A C   1 
ATOM 636  O O   . ASN A 1 146 ? 208.701 289.105 354.468 1.00 136.33 ? 146 ASN A O   1 
ATOM 637  C CB  . ASN A 1 146 ? 209.660 291.238 356.503 1.00 136.61 ? 146 ASN A CB  1 
ATOM 638  C CG  . ASN A 1 146 ? 210.196 289.862 356.842 1.00 137.54 ? 146 ASN A CG  1 
ATOM 639  O OD1 . ASN A 1 146 ? 209.434 288.909 357.003 1.00 137.72 ? 146 ASN A OD1 1 
ATOM 640  N ND2 . ASN A 1 146 ? 211.514 289.751 356.951 1.00 135.99 ? 146 ASN A ND2 1 
ATOM 641  N N   . ASN A 1 147 ? 208.793 291.002 353.251 1.00 132.93 ? 147 ASN A N   1 
ATOM 642  C CA  . ASN A 1 147 ? 208.993 290.280 352.000 1.00 132.12 ? 147 ASN A CA  1 
ATOM 643  C C   . ASN A 1 147 ? 210.294 289.489 352.022 1.00 132.69 ? 147 ASN A C   1 
ATOM 644  O O   . ASN A 1 147 ? 210.308 288.285 351.746 1.00 132.73 ? 147 ASN A O   1 
ATOM 645  C CB  . ASN A 1 147 ? 208.983 291.258 350.826 1.00 131.80 ? 147 ASN A CB  1 
ATOM 646  C CG  . ASN A 1 147 ? 210.000 292.373 350.986 1.00 132.13 ? 147 ASN A CG  1 
ATOM 647  O OD1 . ASN A 1 147 ? 211.183 292.196 350.693 1.00 130.80 ? 147 ASN A OD1 1 
ATOM 648  N ND2 . ASN A 1 147 ? 209.543 293.531 351.451 1.00 131.81 ? 147 ASN A ND2 1 
ATOM 649  N N   . GLY A 1 148 ? 211.403 290.152 352.349 1.00 130.10 ? 148 GLY A N   1 
ATOM 650  C CA  . GLY A 1 148 ? 212.713 289.551 352.244 1.00 128.20 ? 148 GLY A CA  1 
ATOM 651  C C   . GLY A 1 148 ? 213.216 289.370 350.829 1.00 127.89 ? 148 GLY A C   1 
ATOM 652  O O   . GLY A 1 148 ? 214.424 289.170 350.643 1.00 124.79 ? 148 GLY A O   1 
ATOM 653  N N   . HIS A 1 149 ? 212.340 289.443 349.831 1.00 128.99 ? 149 HIS A N   1 
ATOM 654  C CA  . HIS A 1 149 ? 212.704 289.319 348.422 1.00 128.58 ? 149 HIS A CA  1 
ATOM 655  C C   . HIS A 1 149 ? 213.704 288.185 348.210 1.00 127.57 ? 149 HIS A C   1 
ATOM 656  O O   . HIS A 1 149 ? 214.844 288.385 347.793 1.00 126.48 ? 149 HIS A O   1 
ATOM 657  C CB  . HIS A 1 149 ? 213.251 290.639 347.884 1.00 127.92 ? 149 HIS A CB  1 
ATOM 658  C CG  . HIS A 1 149 ? 212.196 291.558 347.351 1.00 128.78 ? 149 HIS A CG  1 
ATOM 659  N ND1 . HIS A 1 149 ? 211.491 291.292 346.197 1.00 128.52 ? 149 HIS A ND1 1 
ATOM 660  C CD2 . HIS A 1 149 ? 211.727 292.743 347.811 1.00 127.86 ? 149 HIS A CD2 1 
ATOM 661  C CE1 . HIS A 1 149 ? 210.632 292.270 345.971 1.00 126.43 ? 149 HIS A CE1 1 
ATOM 662  N NE2 . HIS A 1 149 ? 210.758 293.165 346.935 1.00 125.57 ? 149 HIS A NE2 1 
ATOM 663  N N   . ALA A 1 150 ? 213.260 286.974 348.528 1.00 118.29 ? 150 ALA A N   1 
ATOM 664  C CA  . ALA A 1 150 ? 214.048 285.800 348.189 1.00 117.73 ? 150 ALA A CA  1 
ATOM 665  C C   . ALA A 1 150 ? 214.044 285.593 346.681 1.00 117.21 ? 150 ALA A C   1 
ATOM 666  O O   . ALA A 1 150 ? 212.986 285.539 346.049 1.00 115.40 ? 150 ALA A O   1 
ATOM 667  C CB  . ALA A 1 150 ? 213.490 284.566 348.893 1.00 115.28 ? 150 ALA A CB  1 
ATOM 668  N N   . LEU A 1 151 ? 215.235 285.474 346.103 1.00 99.43  ? 151 LEU A N   1 
ATOM 669  C CA  . LEU A 1 151 ? 215.327 285.212 344.678 1.00 95.74  ? 151 LEU A CA  1 
ATOM 670  C C   . LEU A 1 151 ? 214.695 283.861 344.359 1.00 96.10  ? 151 LEU A C   1 
ATOM 671  O O   . LEU A 1 151 ? 214.716 282.930 345.169 1.00 94.65  ? 151 LEU A O   1 
ATOM 672  C CB  . LEU A 1 151 ? 216.782 285.252 344.213 1.00 95.70  ? 151 LEU A CB  1 
ATOM 673  C CG  . LEU A 1 151 ? 217.470 286.615 344.342 1.00 96.10  ? 151 LEU A CG  1 
ATOM 674  C CD1 . LEU A 1 151 ? 218.243 286.713 345.648 1.00 95.64  ? 151 LEU A CD1 1 
ATOM 675  C CD2 . LEU A 1 151 ? 218.386 286.900 343.157 1.00 93.35  ? 151 LEU A CD2 1 
ATOM 676  N N   . ASN A 1 152 ? 214.118 283.768 343.162 1.00 91.86  ? 152 ASN A N   1 
ATOM 677  C CA  . ASN A 1 152 ? 213.290 282.624 342.800 1.00 91.70  ? 152 ASN A CA  1 
ATOM 678  C C   . ASN A 1 152 ? 213.935 281.317 343.238 1.00 88.47  ? 152 ASN A C   1 
ATOM 679  O O   . ASN A 1 152 ? 215.081 281.023 342.889 1.00 86.91  ? 152 ASN A O   1 
ATOM 680  C CB  . ASN A 1 152 ? 213.047 282.610 341.290 1.00 89.73  ? 152 ASN A CB  1 
ATOM 681  C CG  . ASN A 1 152 ? 214.309 282.342 340.500 1.00 93.14  ? 152 ASN A CG  1 
ATOM 682  O OD1 . ASN A 1 152 ? 215.408 282.698 340.925 1.00 94.82  ? 152 ASN A OD1 1 
ATOM 683  N ND2 . ASN A 1 152 ? 214.160 281.708 339.344 1.00 91.30  ? 152 ASN A ND2 1 
ATOM 684  N N   . GLN A 1 153 ? 213.189 280.537 344.012 1.00 79.20  ? 153 GLN A N   1 
ATOM 685  C CA  . GLN A 1 153 ? 213.696 279.274 344.519 1.00 78.92  ? 153 GLN A CA  1 
ATOM 686  C C   . GLN A 1 153 ? 214.027 278.328 343.372 1.00 81.51  ? 153 GLN A C   1 
ATOM 687  O O   . GLN A 1 153 ? 213.359 278.311 342.336 1.00 79.40  ? 153 GLN A O   1 
ATOM 688  C CB  . GLN A 1 153 ? 212.667 278.622 345.441 1.00 75.09  ? 153 GLN A CB  1 
ATOM 689  C CG  . GLN A 1 153 ? 212.368 279.406 346.706 1.00 77.74  ? 153 GLN A CG  1 
ATOM 690  C CD  . GLN A 1 153 ? 213.473 279.337 347.756 1.00 83.80  ? 153 GLN A CD  1 
ATOM 691  O OE1 . GLN A 1 153 ? 213.344 279.924 348.830 1.00 85.51  ? 153 GLN A OE1 1 
ATOM 692  N NE2 . GLN A 1 153 ? 214.556 278.624 347.457 1.00 82.09  ? 153 GLN A NE2 1 
ATOM 693  N N   . VAL A 1 154 ? 215.080 277.538 343.565 1.00 70.78  ? 154 VAL A N   1 
ATOM 694  C CA  . VAL A 1 154 ? 215.434 276.450 342.664 1.00 66.84  ? 154 VAL A CA  1 
ATOM 695  C C   . VAL A 1 154 ? 215.225 275.144 343.413 1.00 70.11  ? 154 VAL A C   1 
ATOM 696  O O   . VAL A 1 154 ? 215.838 274.916 344.462 1.00 69.62  ? 154 VAL A O   1 
ATOM 697  C CB  . VAL A 1 154 ? 216.881 276.572 342.162 1.00 63.33  ? 154 VAL A CB  1 
ATOM 698  C CG1 . VAL A 1 154 ? 217.236 275.391 341.275 1.00 62.90  ? 154 VAL A CG1 1 
ATOM 699  C CG2 . VAL A 1 154 ? 217.070 277.874 341.412 1.00 65.19  ? 154 VAL A CG2 1 
ATOM 700  N N   . TYR A 1 155 ? 214.355 274.295 342.880 1.00 70.76  ? 155 TYR A N   1 
ATOM 701  C CA  . TYR A 1 155 ? 214.005 273.023 343.490 1.00 64.39  ? 155 TYR A CA  1 
ATOM 702  C C   . TYR A 1 155 ? 214.679 271.896 342.727 1.00 65.17  ? 155 TYR A C   1 
ATOM 703  O O   . TYR A 1 155 ? 214.599 271.838 341.496 1.00 66.32  ? 155 TYR A O   1 
ATOM 704  C CB  . TYR A 1 155 ? 212.490 272.811 343.492 1.00 59.55  ? 155 TYR A CB  1 
ATOM 705  C CG  . TYR A 1 155 ? 211.720 273.827 344.297 1.00 60.90  ? 155 TYR A CG  1 
ATOM 706  C CD1 . TYR A 1 155 ? 211.452 273.615 345.638 1.00 65.49  ? 155 TYR A CD1 1 
ATOM 707  C CD2 . TYR A 1 155 ? 211.252 274.992 343.712 1.00 63.89  ? 155 TYR A CD2 1 
ATOM 708  C CE1 . TYR A 1 155 ? 210.745 274.537 346.376 1.00 66.40  ? 155 TYR A CE1 1 
ATOM 709  C CE2 . TYR A 1 155 ? 210.547 275.920 344.444 1.00 68.35  ? 155 TYR A CE2 1 
ATOM 710  C CZ  . TYR A 1 155 ? 210.296 275.687 345.775 1.00 68.36  ? 155 TYR A CZ  1 
ATOM 711  O OH  . TYR A 1 155 ? 209.592 276.607 346.512 1.00 74.23  ? 155 TYR A OH  1 
ATOM 712  N N   . GLN A 1 156 ? 215.343 271.011 343.457 1.00 59.80  ? 156 GLN A N   1 
ATOM 713  C CA  . GLN A 1 156 ? 215.834 269.765 342.898 1.00 55.50  ? 156 GLN A CA  1 
ATOM 714  C C   . GLN A 1 156 ? 214.812 268.678 343.182 1.00 54.72  ? 156 GLN A C   1 
ATOM 715  O O   . GLN A 1 156 ? 214.436 268.460 344.339 1.00 62.43  ? 156 GLN A O   1 
ATOM 716  C CB  . GLN A 1 156 ? 217.188 269.384 343.490 1.00 63.10  ? 156 GLN A CB  1 
ATOM 717  C CG  . GLN A 1 156 ? 217.793 268.145 342.858 1.00 57.96  ? 156 GLN A CG  1 
ATOM 718  C CD  . GLN A 1 156 ? 219.150 267.808 343.424 1.00 58.17  ? 156 GLN A CD  1 
ATOM 719  O OE1 . GLN A 1 156 ? 219.582 268.388 344.418 1.00 57.64  ? 156 GLN A OE1 1 
ATOM 720  N NE2 . GLN A 1 156 ? 219.834 266.865 342.792 1.00 58.82  ? 156 GLN A NE2 1 
ATOM 721  N N   . ILE A 1 157 ? 214.361 268.017 342.123 1.00 53.56  ? 157 ILE A N   1 
ATOM 722  C CA  . ILE A 1 157 ? 213.351 266.969 342.181 1.00 52.67  ? 157 ILE A CA  1 
ATOM 723  C C   . ILE A 1 157 ? 214.033 265.709 341.676 1.00 53.42  ? 157 ILE A C   1 
ATOM 724  O O   . ILE A 1 157 ? 214.205 265.533 340.466 1.00 66.40  ? 157 ILE A O   1 
ATOM 725  C CB  . ILE A 1 157 ? 212.119 267.310 341.337 1.00 45.15  ? 157 ILE A CB  1 
ATOM 726  C CG1 . ILE A 1 157 ? 211.402 268.535 341.906 1.00 54.88  ? 157 ILE A CG1 1 
ATOM 727  C CG2 . ILE A 1 157 ? 211.183 266.122 341.267 1.00 51.70  ? 157 ILE A CG2 1 
ATOM 728  C CD1 . ILE A 1 157 ? 210.523 269.239 340.905 1.00 53.99  ? 157 ILE A CD1 1 
ATOM 729  N N   . MET A 1 158 ? 214.437 264.839 342.591 1.00 50.95  ? 158 MET A N   1 
ATOM 730  C CA  . MET A 1 158 ? 215.216 263.655 342.267 1.00 52.90  ? 158 MET A CA  1 
ATOM 731  C C   . MET A 1 158 ? 214.306 262.439 342.301 1.00 52.49  ? 158 MET A C   1 
ATOM 732  O O   . MET A 1 158 ? 213.560 262.243 343.266 1.00 52.52  ? 158 MET A O   1 
ATOM 733  C CB  . MET A 1 158 ? 216.366 263.491 343.260 1.00 49.31  ? 158 MET A CB  1 
ATOM 734  C CG  . MET A 1 158 ? 217.252 262.294 343.002 1.00 50.40  ? 158 MET A CG  1 
ATOM 735  S SD  . MET A 1 158 ? 218.476 262.056 344.297 1.00 64.33  ? 158 MET A SD  1 
ATOM 736  C CE  . MET A 1 158 ? 217.419 261.736 345.703 1.00 56.15  ? 158 MET A CE  1 
ATOM 737  N N   . TYR A 1 159 ? 214.365 261.632 341.249 1.00 46.13  ? 159 TYR A N   1 
ATOM 738  C CA  . TYR A 1 159 ? 213.601 260.391 341.173 1.00 43.01  ? 159 TYR A CA  1 
ATOM 739  C C   . TYR A 1 159 ? 214.538 259.246 341.523 1.00 46.27  ? 159 TYR A C   1 
ATOM 740  O O   . TYR A 1 159 ? 215.339 258.812 340.694 1.00 52.33  ? 159 TYR A O   1 
ATOM 741  C CB  . TYR A 1 159 ? 212.993 260.199 339.792 1.00 42.72  ? 159 TYR A CB  1 
ATOM 742  C CG  . TYR A 1 159 ? 212.494 258.796 339.565 1.00 40.40  ? 159 TYR A CG  1 
ATOM 743  C CD1 . TYR A 1 159 ? 211.496 258.263 340.358 1.00 38.45  ? 159 TYR A CD1 1 
ATOM 744  C CD2 . TYR A 1 159 ? 213.023 258.005 338.560 1.00 45.74  ? 159 TYR A CD2 1 
ATOM 745  C CE1 . TYR A 1 159 ? 211.037 256.983 340.158 1.00 39.03  ? 159 TYR A CE1 1 
ATOM 746  C CE2 . TYR A 1 159 ? 212.568 256.722 338.351 1.00 40.90  ? 159 TYR A CE2 1 
ATOM 747  C CZ  . TYR A 1 159 ? 211.576 256.217 339.154 1.00 40.44  ? 159 TYR A CZ  1 
ATOM 748  O OH  . TYR A 1 159 ? 211.120 254.939 338.955 1.00 56.11  ? 159 TYR A OH  1 
ATOM 749  N N   . VAL A 1 160 ? 214.429 258.755 342.751 1.00 48.92  ? 160 VAL A N   1 
ATOM 750  C CA  . VAL A 1 160 ? 215.253 257.654 343.240 1.00 48.07  ? 160 VAL A CA  1 
ATOM 751  C C   . VAL A 1 160 ? 214.666 256.346 342.723 1.00 45.58  ? 160 VAL A C   1 
ATOM 752  O O   . VAL A 1 160 ? 213.642 255.893 343.249 1.00 54.29  ? 160 VAL A O   1 
ATOM 753  C CB  . VAL A 1 160 ? 215.312 257.657 344.773 1.00 49.82  ? 160 VAL A CB  1 
ATOM 754  C CG1 . VAL A 1 160 ? 216.298 256.625 345.263 1.00 52.63  ? 160 VAL A CG1 1 
ATOM 755  C CG2 . VAL A 1 160 ? 215.671 259.033 345.285 1.00 47.55  ? 160 VAL A CG2 1 
ATOM 756  N N   . PRO A 1 161 ? 215.266 255.698 341.730 1.00 34.46  ? 161 PRO A N   1 
ATOM 757  C CA  . PRO A 1 161 ? 214.647 254.504 341.151 1.00 45.57  ? 161 PRO A CA  1 
ATOM 758  C C   . PRO A 1 161 ? 214.420 253.441 342.209 1.00 55.22  ? 161 PRO A C   1 
ATOM 759  O O   . PRO A 1 161 ? 214.850 253.598 343.361 1.00 55.98  ? 161 PRO A O   1 
ATOM 760  C CB  . PRO A 1 161 ? 215.672 254.045 340.105 1.00 44.81  ? 161 PRO A CB  1 
ATOM 761  C CG  . PRO A 1 161 ? 216.489 255.236 339.822 1.00 47.29  ? 161 PRO A CG  1 
ATOM 762  C CD  . PRO A 1 161 ? 216.564 255.985 341.105 1.00 44.61  ? 161 PRO A CD  1 
ATOM 763  N N   . PRO A 1 162 ? 213.739 252.349 341.866 1.00 48.98  ? 162 PRO A N   1 
ATOM 764  C CA  . PRO A 1 162 ? 213.457 251.318 342.871 1.00 41.68  ? 162 PRO A CA  1 
ATOM 765  C C   . PRO A 1 162 ? 214.729 250.604 343.300 1.00 52.75  ? 162 PRO A C   1 
ATOM 766  O O   . PRO A 1 162 ? 215.474 250.078 342.471 1.00 55.32  ? 162 PRO A O   1 
ATOM 767  C CB  . PRO A 1 162 ? 212.493 250.373 342.148 1.00 44.06  ? 162 PRO A CB  1 
ATOM 768  C CG  . PRO A 1 162 ? 212.792 250.562 340.716 1.00 41.03  ? 162 PRO A CG  1 
ATOM 769  C CD  . PRO A 1 162 ? 213.193 251.992 340.547 1.00 43.74  ? 162 PRO A CD  1 
ATOM 770  N N   . GLY A 1 163 ? 214.970 250.586 344.607 1.00 59.75  ? 163 GLY A N   1 
ATOM 771  C CA  . GLY A 1 163 ? 216.098 249.899 345.187 1.00 56.42  ? 163 GLY A CA  1 
ATOM 772  C C   . GLY A 1 163 ? 217.264 250.793 345.550 1.00 56.50  ? 163 GLY A C   1 
ATOM 773  O O   . GLY A 1 163 ? 218.104 250.390 346.362 1.00 59.64  ? 163 GLY A O   1 
ATOM 774  N N   . ALA A 1 164 ? 217.336 251.992 344.983 1.00 55.64  ? 164 ALA A N   1 
ATOM 775  C CA  . ALA A 1 164 ? 218.429 252.891 345.289 1.00 59.21  ? 164 ALA A CA  1 
ATOM 776  C C   . ALA A 1 164 ? 218.282 253.436 346.707 1.00 59.89  ? 164 ALA A C   1 
ATOM 777  O O   . ALA A 1 164 ? 217.197 253.393 347.289 1.00 62.90  ? 164 ALA A O   1 
ATOM 778  C CB  . ALA A 1 164 ? 218.475 254.033 344.281 1.00 57.77  ? 164 ALA A CB  1 
ATOM 779  N N   . PRO A 1 165 ? 219.365 253.946 347.291 1.00 63.85  ? 165 PRO A N   1 
ATOM 780  C CA  . PRO A 1 165 ? 219.280 254.457 348.664 1.00 62.16  ? 165 PRO A CA  1 
ATOM 781  C C   . PRO A 1 165 ? 218.277 255.595 348.773 1.00 62.67  ? 165 PRO A C   1 
ATOM 782  O O   . PRO A 1 165 ? 218.147 256.424 347.871 1.00 61.43  ? 165 PRO A O   1 
ATOM 783  C CB  . PRO A 1 165 ? 220.707 254.934 348.958 1.00 65.79  ? 165 PRO A CB  1 
ATOM 784  C CG  . PRO A 1 165 ? 221.567 254.241 347.959 1.00 65.24  ? 165 PRO A CG  1 
ATOM 785  C CD  . PRO A 1 165 ? 220.724 254.076 346.739 1.00 63.77  ? 165 PRO A CD  1 
ATOM 786  N N   . VAL A 1 166 ? 217.571 255.630 349.898 1.00 63.59  ? 166 VAL A N   1 
ATOM 787  C CA  . VAL A 1 166 ? 216.580 256.669 350.169 1.00 59.89  ? 166 VAL A CA  1 
ATOM 788  C C   . VAL A 1 166 ? 217.270 257.826 350.881 1.00 68.29  ? 166 VAL A C   1 
ATOM 789  O O   . VAL A 1 166 ? 217.908 257.609 351.920 1.00 72.92  ? 166 VAL A O   1 
ATOM 790  C CB  . VAL A 1 166 ? 215.419 256.123 351.012 1.00 62.50  ? 166 VAL A CB  1 
ATOM 791  C CG1 . VAL A 1 166 ? 214.366 257.198 351.219 1.00 60.46  ? 166 VAL A CG1 1 
ATOM 792  C CG2 . VAL A 1 166 ? 214.818 254.892 350.353 1.00 63.99  ? 166 VAL A CG2 1 
ATOM 793  N N   . PRO A 1 167 ? 217.181 259.057 350.376 1.00 67.98  ? 167 PRO A N   1 
ATOM 794  C CA  . PRO A 1 167 ? 217.836 260.175 351.065 1.00 68.92  ? 167 PRO A CA  1 
ATOM 795  C C   . PRO A 1 167 ? 217.350 260.311 352.500 1.00 71.61  ? 167 PRO A C   1 
ATOM 796  O O   . PRO A 1 167 ? 216.165 260.144 352.795 1.00 67.85  ? 167 PRO A O   1 
ATOM 797  C CB  . PRO A 1 167 ? 217.442 261.390 350.221 1.00 66.42  ? 167 PRO A CB  1 
ATOM 798  C CG  . PRO A 1 167 ? 217.151 260.840 348.881 1.00 62.18  ? 167 PRO A CG  1 
ATOM 799  C CD  . PRO A 1 167 ? 216.564 259.484 349.109 1.00 62.97  ? 167 PRO A CD  1 
ATOM 800  N N   . GLU A 1 168 ? 218.287 260.617 353.395 1.00 80.96  ? 168 GLU A N   1 
ATOM 801  C CA  . GLU A 1 168 ? 217.984 260.824 354.803 1.00 82.10  ? 168 GLU A CA  1 
ATOM 802  C C   . GLU A 1 168 ? 218.463 262.174 355.316 1.00 82.88  ? 168 GLU A C   1 
ATOM 803  O O   . GLU A 1 168 ? 218.261 262.479 356.496 1.00 83.00  ? 168 GLU A O   1 
ATOM 804  C CB  . GLU A 1 168 ? 218.605 259.706 355.650 1.00 84.12  ? 168 GLU A CB  1 
ATOM 805  C CG  . GLU A 1 168 ? 220.112 259.580 355.507 1.00 85.44  ? 168 GLU A CG  1 
ATOM 806  C CD  . GLU A 1 168 ? 220.683 258.451 356.345 1.00 86.42  ? 168 GLU A CD  1 
ATOM 807  O OE1 . GLU A 1 168 ? 219.896 257.604 356.818 1.00 85.48  ? 168 GLU A OE1 1 
ATOM 808  O OE2 . GLU A 1 168 ? 221.917 258.412 356.534 1.00 84.09  ? 168 GLU A OE2 1 
ATOM 809  N N   . LYS A 1 169 ? 219.092 262.985 354.469 1.00 83.80  ? 169 LYS A N   1 
ATOM 810  C CA  . LYS A 1 169 ? 219.525 264.320 354.848 1.00 86.48  ? 169 LYS A CA  1 
ATOM 811  C C   . LYS A 1 169 ? 219.451 265.219 353.625 1.00 86.86  ? 169 LYS A C   1 
ATOM 812  O O   . LYS A 1 169 ? 219.496 264.754 352.484 1.00 87.23  ? 169 LYS A O   1 
ATOM 813  C CB  . LYS A 1 169 ? 220.949 264.316 355.415 1.00 85.73  ? 169 LYS A CB  1 
ATOM 814  C CG  . LYS A 1 169 ? 221.065 263.781 356.831 1.00 89.06  ? 169 LYS A CG  1 
ATOM 815  C CD  . LYS A 1 169 ? 220.428 264.728 357.835 1.00 89.81  ? 169 LYS A CD  1 
ATOM 816  C CE  . LYS A 1 169 ? 220.659 264.261 359.261 1.00 87.96  ? 169 LYS A CE  1 
ATOM 817  N NZ  . LYS A 1 169 ? 220.062 265.193 360.254 1.00 87.57  ? 169 LYS A NZ  1 
ATOM 818  N N   . TRP A 1 170 ? 219.344 266.519 353.877 1.00 84.78  ? 170 TRP A N   1 
ATOM 819  C CA  . TRP A 1 170 ? 219.307 267.496 352.798 1.00 85.52  ? 170 TRP A CA  1 
ATOM 820  C C   . TRP A 1 170 ? 220.672 267.728 352.171 1.00 87.03  ? 170 TRP A C   1 
ATOM 821  O O   . TRP A 1 170 ? 220.780 268.537 351.245 1.00 87.11  ? 170 TRP A O   1 
ATOM 822  C CB  . TRP A 1 170 ? 218.750 268.823 353.310 1.00 90.13  ? 170 TRP A CB  1 
ATOM 823  C CG  . TRP A 1 170 ? 219.577 269.446 354.386 1.00 92.14  ? 170 TRP A CG  1 
ATOM 824  C CD1 . TRP A 1 170 ? 219.487 269.214 355.726 1.00 90.84  ? 170 TRP A CD1 1 
ATOM 825  C CD2 . TRP A 1 170 ? 220.620 270.411 354.215 1.00 92.29  ? 170 TRP A CD2 1 
ATOM 826  N NE1 . TRP A 1 170 ? 220.410 269.974 356.401 1.00 91.86  ? 170 TRP A NE1 1 
ATOM 827  C CE2 . TRP A 1 170 ? 221.118 270.718 355.495 1.00 91.73  ? 170 TRP A CE2 1 
ATOM 828  C CE3 . TRP A 1 170 ? 221.182 271.044 353.103 1.00 88.83  ? 170 TRP A CE3 1 
ATOM 829  C CZ2 . TRP A 1 170 ? 222.151 271.630 355.695 1.00 90.38  ? 170 TRP A CZ2 1 
ATOM 830  C CZ3 . TRP A 1 170 ? 222.207 271.950 353.303 1.00 87.52  ? 170 TRP A CZ3 1 
ATOM 831  C CH2 . TRP A 1 170 ? 222.681 272.234 354.589 1.00 90.49  ? 170 TRP A CH2 1 
ATOM 832  N N   . ASP A 1 171 ? 221.711 267.047 352.658 1.00 88.62  ? 171 ASP A N   1 
ATOM 833  C CA  . ASP A 1 171 ? 223.053 267.151 352.099 1.00 87.56  ? 171 ASP A CA  1 
ATOM 834  C C   . ASP A 1 171 ? 223.654 265.775 351.835 1.00 87.65  ? 171 ASP A C   1 
ATOM 835  O O   . ASP A 1 171 ? 224.877 265.650 351.718 1.00 84.65  ? 171 ASP A O   1 
ATOM 836  C CB  . ASP A 1 171 ? 223.960 267.954 353.032 1.00 85.21  ? 171 ASP A CB  1 
ATOM 837  C CG  . ASP A 1 171 ? 223.890 267.472 354.465 1.00 87.78  ? 171 ASP A CG  1 
ATOM 838  O OD1 . ASP A 1 171 ? 224.135 266.271 354.702 1.00 88.80  ? 171 ASP A OD1 1 
ATOM 839  O OD2 . ASP A 1 171 ? 223.592 268.294 355.356 1.00 87.80  ? 171 ASP A OD2 1 
ATOM 840  N N   . ASP A 1 172 ? 222.822 264.743 351.743 1.00 84.79  ? 172 ASP A N   1 
ATOM 841  C CA  . ASP A 1 172 ? 223.316 263.396 351.517 1.00 76.67  ? 172 ASP A CA  1 
ATOM 842  C C   . ASP A 1 172 ? 223.855 263.251 350.098 1.00 75.01  ? 172 ASP A C   1 
ATOM 843  O O   . ASP A 1 172 ? 223.510 264.010 349.189 1.00 77.95  ? 172 ASP A O   1 
ATOM 844  C CB  . ASP A 1 172 ? 222.207 262.375 351.757 1.00 75.96  ? 172 ASP A CB  1 
ATOM 845  C CG  . ASP A 1 172 ? 222.720 260.956 351.750 1.00 76.22  ? 172 ASP A CG  1 
ATOM 846  O OD1 . ASP A 1 172 ? 223.955 260.779 351.746 1.00 75.68  ? 172 ASP A OD1 1 
ATOM 847  O OD2 . ASP A 1 172 ? 221.894 260.019 351.748 1.00 77.66  ? 172 ASP A OD2 1 
ATOM 848  N N   . TYR A 1 173 ? 224.719 262.252 349.913 1.00 66.58  ? 173 TYR A N   1 
ATOM 849  C CA  . TYR A 1 173 ? 225.316 262.037 348.601 1.00 68.98  ? 173 TYR A CA  1 
ATOM 850  C C   . TYR A 1 173 ? 224.266 261.681 347.559 1.00 67.79  ? 173 TYR A C   1 
ATOM 851  O O   . TYR A 1 173 ? 224.465 261.939 346.367 1.00 70.79  ? 173 TYR A O   1 
ATOM 852  C CB  . TYR A 1 173 ? 226.368 260.932 348.675 1.00 67.85  ? 173 TYR A CB  1 
ATOM 853  C CG  . TYR A 1 173 ? 225.781 259.551 348.835 1.00 67.81  ? 173 TYR A CG  1 
ATOM 854  C CD1 . TYR A 1 173 ? 225.534 259.025 350.092 1.00 67.61  ? 173 TYR A CD1 1 
ATOM 855  C CD2 . TYR A 1 173 ? 225.473 258.774 347.729 1.00 65.31  ? 173 TYR A CD2 1 
ATOM 856  C CE1 . TYR A 1 173 ? 224.996 257.768 350.243 1.00 65.28  ? 173 TYR A CE1 1 
ATOM 857  C CE2 . TYR A 1 173 ? 224.935 257.516 347.871 1.00 67.58  ? 173 TYR A CE2 1 
ATOM 858  C CZ  . TYR A 1 173 ? 224.699 257.018 349.130 1.00 68.36  ? 173 TYR A CZ  1 
ATOM 859  O OH  . TYR A 1 173 ? 224.163 255.762 349.280 1.00 74.44  ? 173 TYR A OH  1 
ATOM 860  N N   . THR A 1 174 ? 223.146 261.091 347.984 1.00 62.62  ? 174 THR A N   1 
ATOM 861  C CA  . THR A 1 174 ? 222.147 260.631 347.025 1.00 63.30  ? 174 THR A CA  1 
ATOM 862  C C   . THR A 1 174 ? 221.696 261.756 346.108 1.00 62.65  ? 174 THR A C   1 
ATOM 863  O O   . THR A 1 174 ? 221.355 261.510 344.947 1.00 65.49  ? 174 THR A O   1 
ATOM 864  C CB  . THR A 1 174 ? 220.947 260.037 347.758 1.00 66.81  ? 174 THR A CB  1 
ATOM 865  O OG1 . THR A 1 174 ? 220.471 260.970 348.735 1.00 67.80  ? 174 THR A OG1 1 
ATOM 866  C CG2 . THR A 1 174 ? 221.331 258.743 348.446 1.00 65.97  ? 174 THR A CG2 1 
ATOM 867  N N   . TRP A 1 175 ? 221.688 262.992 346.602 1.00 62.51  ? 175 TRP A N   1 
ATOM 868  C CA  . TRP A 1 175 ? 221.356 264.120 345.742 1.00 62.28  ? 175 TRP A CA  1 
ATOM 869  C C   . TRP A 1 175 ? 222.396 264.294 344.644 1.00 62.25  ? 175 TRP A C   1 
ATOM 870  O O   . TRP A 1 175 ? 222.053 264.599 343.496 1.00 62.39  ? 175 TRP A O   1 
ATOM 871  C CB  . TRP A 1 175 ? 221.237 265.392 346.576 1.00 60.08  ? 175 TRP A CB  1 
ATOM 872  C CG  . TRP A 1 175 ? 220.241 265.276 347.678 1.00 63.63  ? 175 TRP A CG  1 
ATOM 873  C CD1 . TRP A 1 175 ? 220.500 265.043 348.992 1.00 61.14  ? 175 TRP A CD1 1 
ATOM 874  C CD2 . TRP A 1 175 ? 218.820 265.380 347.561 1.00 67.10  ? 175 TRP A CD2 1 
ATOM 875  N NE1 . TRP A 1 175 ? 219.330 264.999 349.705 1.00 55.36  ? 175 TRP A NE1 1 
ATOM 876  C CE2 . TRP A 1 175 ? 218.283 265.202 348.847 1.00 60.12  ? 175 TRP A CE2 1 
ATOM 877  C CE3 . TRP A 1 175 ? 217.949 265.608 346.492 1.00 62.55  ? 175 TRP A CE3 1 
ATOM 878  C CZ2 . TRP A 1 175 ? 216.917 265.248 349.095 1.00 57.09  ? 175 TRP A CZ2 1 
ATOM 879  C CZ3 . TRP A 1 175 ? 216.598 265.651 346.739 1.00 54.18  ? 175 TRP A CZ3 1 
ATOM 880  C CH2 . TRP A 1 175 ? 216.093 265.474 348.029 1.00 57.88  ? 175 TRP A CH2 1 
ATOM 881  N N   . GLN A 1 176 ? 223.671 264.103 344.976 1.00 65.89  ? 176 GLN A N   1 
ATOM 882  C CA  . GLN A 1 176 ? 224.756 264.277 344.022 1.00 64.17  ? 176 GLN A CA  1 
ATOM 883  C C   . GLN A 1 176 ? 225.108 262.999 343.274 1.00 62.96  ? 176 GLN A C   1 
ATOM 884  O O   . GLN A 1 176 ? 225.947 263.046 342.370 1.00 58.84  ? 176 GLN A O   1 
ATOM 885  C CB  . GLN A 1 176 ? 226.011 264.791 344.736 1.00 61.35  ? 176 GLN A CB  1 
ATOM 886  C CG  . GLN A 1 176 ? 225.759 265.867 345.786 1.00 65.93  ? 176 GLN A CG  1 
ATOM 887  C CD  . GLN A 1 176 ? 225.222 267.157 345.200 1.00 72.57  ? 176 GLN A CD  1 
ATOM 888  O OE1 . GLN A 1 176 ? 224.701 267.179 344.086 1.00 70.36  ? 176 GLN A OE1 1 
ATOM 889  N NE2 . GLN A 1 176 ? 225.350 268.244 345.951 1.00 72.66  ? 176 GLN A NE2 1 
ATOM 890  N N   . THR A 1 177 ? 224.497 261.869 343.617 1.00 61.48  ? 177 THR A N   1 
ATOM 891  C CA  . THR A 1 177 ? 224.858 260.611 342.983 1.00 59.17  ? 177 THR A CA  1 
ATOM 892  C C   . THR A 1 177 ? 224.497 260.632 341.503 1.00 52.75  ? 177 THR A C   1 
ATOM 893  O O   . THR A 1 177 ? 223.556 261.303 341.077 1.00 55.49  ? 177 THR A O   1 
ATOM 894  C CB  . THR A 1 177 ? 224.161 259.440 343.671 1.00 55.21  ? 177 THR A CB  1 
ATOM 895  O OG1 . THR A 1 177 ? 224.761 258.211 343.249 1.00 57.01  ? 177 THR A OG1 1 
ATOM 896  C CG2 . THR A 1 177 ? 222.694 259.415 343.317 1.00 55.65  ? 177 THR A CG2 1 
ATOM 897  N N   . SER A 1 178 ? 225.266 259.883 340.715 1.00 48.89  ? 178 SER A N   1 
ATOM 898  C CA  . SER A 1 178 ? 225.103 259.908 339.267 1.00 49.75  ? 178 SER A CA  1 
ATOM 899  C C   . SER A 1 178 ? 223.873 259.140 338.806 1.00 43.93  ? 178 SER A C   1 
ATOM 900  O O   . SER A 1 178 ? 223.273 259.499 337.787 1.00 48.78  ? 178 SER A O   1 
ATOM 901  C CB  . SER A 1 178 ? 226.347 259.329 338.594 1.00 51.58  ? 178 SER A CB  1 
ATOM 902  O OG  . SER A 1 178 ? 227.521 259.992 339.032 1.00 51.45  ? 178 SER A OG  1 
ATOM 903  N N   . SER A 1 179 ? 223.486 258.089 339.527 1.00 38.94  ? 179 SER A N   1 
ATOM 904  C CA  . SER A 1 179 ? 222.429 257.210 339.038 1.00 50.41  ? 179 SER A CA  1 
ATOM 905  C C   . SER A 1 179 ? 221.068 257.895 339.074 1.00 48.51  ? 179 SER A C   1 
ATOM 906  O O   . SER A 1 179 ? 220.311 257.840 338.100 1.00 47.91  ? 179 SER A O   1 
ATOM 907  C CB  . SER A 1 179 ? 222.403 255.924 339.859 1.00 52.85  ? 179 SER A CB  1 
ATOM 908  O OG  . SER A 1 179 ? 222.209 256.203 341.232 1.00 50.91  ? 179 SER A OG  1 
ATOM 909  N N   . ASN A 1 180 ? 220.742 258.547 340.181 1.00 50.85  ? 180 ASN A N   1 
ATOM 910  C CA  . ASN A 1 180 ? 219.404 259.099 340.359 1.00 39.32  ? 180 ASN A CA  1 
ATOM 911  C C   . ASN A 1 180 ? 219.178 260.271 339.414 1.00 47.96  ? 180 ASN A C   1 
ATOM 912  O O   . ASN A 1 180 ? 219.882 261.282 339.526 1.00 49.76  ? 180 ASN A O   1 
ATOM 913  C CB  . ASN A 1 180 ? 219.215 259.555 341.799 1.00 34.97  ? 180 ASN A CB  1 
ATOM 914  C CG  . ASN A 1 180 ? 219.449 258.445 342.794 1.00 46.83  ? 180 ASN A CG  1 
ATOM 915  O OD1 . ASN A 1 180 ? 219.451 257.271 342.438 1.00 55.09  ? 180 ASN A OD1 1 
ATOM 916  N ND2 . ASN A 1 180 ? 219.639 258.811 344.052 1.00 48.49  ? 180 ASN A ND2 1 
ATOM 917  N N   . PRO A 1 181 ? 218.219 260.199 338.493 1.00 48.50  ? 181 PRO A N   1 
ATOM 918  C CA  . PRO A 1 181 ? 217.902 261.375 337.678 1.00 41.68  ? 181 PRO A CA  1 
ATOM 919  C C   . PRO A 1 181 ? 217.302 262.481 338.526 1.00 42.95  ? 181 PRO A C   1 
ATOM 920  O O   . PRO A 1 181 ? 216.651 262.233 339.544 1.00 48.40  ? 181 PRO A O   1 
ATOM 921  C CB  . PRO A 1 181 ? 216.888 260.844 336.659 1.00 37.90  ? 181 PRO A CB  1 
ATOM 922  C CG  . PRO A 1 181 ? 217.054 259.370 336.673 1.00 43.89  ? 181 PRO A CG  1 
ATOM 923  C CD  . PRO A 1 181 ? 217.442 259.025 338.068 1.00 49.07  ? 181 PRO A CD  1 
ATOM 924  N N   . SER A 1 182 ? 217.530 263.719 338.097 1.00 44.24  ? 182 SER A N   1 
ATOM 925  C CA  . SER A 1 182 ? 217.045 264.878 338.825 1.00 40.36  ? 182 SER A CA  1 
ATOM 926  C C   . SER A 1 182 ? 216.614 265.957 337.848 1.00 50.68  ? 182 SER A C   1 
ATOM 927  O O   . SER A 1 182 ? 217.138 266.063 336.737 1.00 55.98  ? 182 SER A O   1 
ATOM 928  C CB  . SER A 1 182 ? 218.110 265.437 339.773 1.00 46.19  ? 182 SER A CB  1 
ATOM 929  O OG  . SER A 1 182 ? 218.406 264.513 340.802 1.00 56.22  ? 182 SER A OG  1 
ATOM 930  N N   . ILE A 1 183 ? 215.650 266.756 338.283 1.00 55.38  ? 183 ILE A N   1 
ATOM 931  C CA  . ILE A 1 183 ? 215.172 267.917 337.549 1.00 47.06  ? 183 ILE A CA  1 
ATOM 932  C C   . ILE A 1 183 ? 215.417 269.147 338.405 1.00 49.76  ? 183 ILE A C   1 
ATOM 933  O O   . ILE A 1 183 ? 215.250 269.119 339.627 1.00 53.08  ? 183 ILE A O   1 
ATOM 934  C CB  . ILE A 1 183 ? 213.678 267.793 337.185 1.00 43.20  ? 183 ILE A CB  1 
ATOM 935  C CG1 . ILE A 1 183 ? 213.527 266.971 335.908 1.00 48.81  ? 183 ILE A CG1 1 
ATOM 936  C CG2 . ILE A 1 183 ? 213.045 269.173 337.043 1.00 53.94  ? 183 ILE A CG2 1 
ATOM 937  C CD1 . ILE A 1 183 ? 212.106 266.745 335.488 1.00 49.32  ? 183 ILE A CD1 1 
ATOM 938  N N   . PHE A 1 184 ? 215.829 270.230 337.760 1.00 48.22  ? 184 PHE A N   1 
ATOM 939  C CA  . PHE A 1 184 ? 216.027 271.506 338.428 1.00 49.14  ? 184 PHE A CA  1 
ATOM 940  C C   . PHE A 1 184 ? 214.963 272.477 337.945 1.00 51.81  ? 184 PHE A C   1 
ATOM 941  O O   . PHE A 1 184 ? 214.819 272.699 336.739 1.00 60.35  ? 184 PHE A O   1 
ATOM 942  C CB  . PHE A 1 184 ? 217.431 272.045 338.167 1.00 53.94  ? 184 PHE A CB  1 
ATOM 943  C CG  . PHE A 1 184 ? 218.498 271.277 338.880 1.00 48.59  ? 184 PHE A CG  1 
ATOM 944  C CD1 . PHE A 1 184 ? 218.856 271.609 340.172 1.00 49.33  ? 184 PHE A CD1 1 
ATOM 945  C CD2 . PHE A 1 184 ? 219.125 270.208 338.270 1.00 45.00  ? 184 PHE A CD2 1 
ATOM 946  C CE1 . PHE A 1 184 ? 219.824 270.900 340.836 1.00 49.19  ? 184 PHE A CE1 1 
ATOM 947  C CE2 . PHE A 1 184 ? 220.095 269.496 338.932 1.00 50.98  ? 184 PHE A CE2 1 
ATOM 948  C CZ  . PHE A 1 184 ? 220.445 269.843 340.216 1.00 54.54  ? 184 PHE A CZ  1 
ATOM 949  N N   . TYR A 1 185 ? 214.218 273.042 338.887 1.00 56.50  ? 185 TYR A N   1 
ATOM 950  C CA  . TYR A 1 185 ? 213.012 273.794 338.584 1.00 63.49  ? 185 TYR A CA  1 
ATOM 951  C C   . TYR A 1 185 ? 213.097 275.170 339.219 1.00 65.86  ? 185 TYR A C   1 
ATOM 952  O O   . TYR A 1 185 ? 213.248 275.282 340.437 1.00 69.99  ? 185 TYR A O   1 
ATOM 953  C CB  . TYR A 1 185 ? 211.783 273.044 339.099 1.00 61.49  ? 185 TYR A CB  1 
ATOM 954  C CG  . TYR A 1 185 ? 210.472 273.701 338.769 1.00 54.31  ? 185 TYR A CG  1 
ATOM 955  C CD1 . TYR A 1 185 ? 209.865 273.495 337.545 1.00 53.69  ? 185 TYR A CD1 1 
ATOM 956  C CD2 . TYR A 1 185 ? 209.835 274.518 339.687 1.00 57.69  ? 185 TYR A CD2 1 
ATOM 957  C CE1 . TYR A 1 185 ? 208.668 274.088 337.241 1.00 64.10  ? 185 TYR A CE1 1 
ATOM 958  C CE2 . TYR A 1 185 ? 208.635 275.116 339.391 1.00 65.72  ? 185 TYR A CE2 1 
ATOM 959  C CZ  . TYR A 1 185 ? 208.055 274.898 338.166 1.00 67.65  ? 185 TYR A CZ  1 
ATOM 960  O OH  . TYR A 1 185 ? 206.854 275.492 337.860 1.00 66.90  ? 185 TYR A OH  1 
ATOM 961  N N   . THR A 1 186 ? 212.988 276.209 338.402 1.00 66.62  ? 186 THR A N   1 
ATOM 962  C CA  . THR A 1 186 ? 212.971 277.584 338.880 1.00 64.25  ? 186 THR A CA  1 
ATOM 963  C C   . THR A 1 186 ? 211.522 278.006 339.069 1.00 68.83  ? 186 THR A C   1 
ATOM 964  O O   . THR A 1 186 ? 210.742 277.997 338.112 1.00 68.78  ? 186 THR A O   1 
ATOM 965  C CB  . THR A 1 186 ? 213.674 278.514 337.894 1.00 69.52  ? 186 THR A CB  1 
ATOM 966  O OG1 . THR A 1 186 ? 213.135 278.315 336.583 1.00 72.24  ? 186 THR A OG1 1 
ATOM 967  C CG2 . THR A 1 186 ? 215.167 278.243 337.873 1.00 70.09  ? 186 THR A CG2 1 
ATOM 968  N N   . TYR A 1 187 ? 211.167 278.375 340.295 1.00 69.55  ? 187 TYR A N   1 
ATOM 969  C CA  . TYR A 1 187 ? 209.785 278.711 340.606 1.00 68.51  ? 187 TYR A CA  1 
ATOM 970  C C   . TYR A 1 187 ? 209.267 279.777 339.653 1.00 68.14  ? 187 TYR A C   1 
ATOM 971  O O   . TYR A 1 187 ? 209.734 280.918 339.668 1.00 69.48  ? 187 TYR A O   1 
ATOM 972  C CB  . TYR A 1 187 ? 209.683 279.197 342.051 1.00 66.92  ? 187 TYR A CB  1 
ATOM 973  C CG  . TYR A 1 187 ? 208.269 279.428 342.540 1.00 68.76  ? 187 TYR A CG  1 
ATOM 974  C CD1 . TYR A 1 187 ? 207.171 279.067 341.771 1.00 71.94  ? 187 TYR A CD1 1 
ATOM 975  C CD2 . TYR A 1 187 ? 208.035 280.014 343.772 1.00 68.51  ? 187 TYR A CD2 1 
ATOM 976  C CE1 . TYR A 1 187 ? 205.887 279.282 342.218 1.00 72.74  ? 187 TYR A CE1 1 
ATOM 977  C CE2 . TYR A 1 187 ? 206.754 280.231 344.224 1.00 71.54  ? 187 TYR A CE2 1 
ATOM 978  C CZ  . TYR A 1 187 ? 205.685 279.864 343.444 1.00 74.03  ? 187 TYR A CZ  1 
ATOM 979  O OH  . TYR A 1 187 ? 204.406 280.080 343.897 1.00 76.23  ? 187 TYR A OH  1 
ATOM 980  N N   . GLY A 1 188 ? 208.291 279.399 338.831 1.00 57.30  ? 188 GLY A N   1 
ATOM 981  C CA  . GLY A 1 188 ? 207.671 280.332 337.913 1.00 57.95  ? 188 GLY A CA  1 
ATOM 982  C C   . GLY A 1 188 ? 207.463 279.761 336.527 1.00 57.54  ? 188 GLY A C   1 
ATOM 983  O O   . GLY A 1 188 ? 206.516 280.139 335.833 1.00 63.29  ? 188 GLY A O   1 
ATOM 984  N N   . THR A 1 189 ? 208.333 278.849 336.111 1.00 57.53  ? 189 THR A N   1 
ATOM 985  C CA  . THR A 1 189 ? 208.288 278.317 334.759 1.00 59.64  ? 189 THR A CA  1 
ATOM 986  C C   . THR A 1 189 ? 207.241 277.212 334.651 1.00 58.38  ? 189 THR A C   1 
ATOM 987  O O   . THR A 1 189 ? 206.547 276.878 335.613 1.00 61.20  ? 189 THR A O   1 
ATOM 988  C CB  . THR A 1 189 ? 209.660 277.788 334.345 1.00 62.30  ? 189 THR A CB  1 
ATOM 989  O OG1 . THR A 1 189 ? 209.923 276.553 335.021 1.00 62.05  ? 189 THR A OG1 1 
ATOM 990  C CG2 . THR A 1 189 ? 210.748 278.792 334.698 1.00 59.85  ? 189 THR A CG2 1 
ATOM 991  N N   . ALA A 1 190 ? 207.141 276.632 333.458 1.00 51.44  ? 190 ALA A N   1 
ATOM 992  C CA  . ALA A 1 190 ? 206.149 275.600 333.194 1.00 48.92  ? 190 ALA A CA  1 
ATOM 993  C C   . ALA A 1 190 ? 206.423 274.396 334.086 1.00 50.91  ? 190 ALA A C   1 
ATOM 994  O O   . ALA A 1 190 ? 207.580 274.139 334.433 1.00 60.57  ? 190 ALA A O   1 
ATOM 995  C CB  . ALA A 1 190 ? 206.169 275.193 331.721 1.00 48.00  ? 190 ALA A CB  1 
ATOM 996  N N   . PRO A 1 191 ? 205.400 273.634 334.472 1.00 44.44  ? 191 PRO A N   1 
ATOM 997  C CA  . PRO A 1 191 ? 205.614 272.560 335.449 1.00 47.53  ? 191 PRO A CA  1 
ATOM 998  C C   . PRO A 1 191 ? 206.605 271.517 334.959 1.00 52.89  ? 191 PRO A C   1 
ATOM 999  O O   . PRO A 1 191 ? 206.657 271.186 333.773 1.00 51.90  ? 191 PRO A O   1 
ATOM 1000 C CB  . PRO A 1 191 ? 204.216 271.957 335.621 1.00 50.53  ? 191 PRO A CB  1 
ATOM 1001 C CG  . PRO A 1 191 ? 203.288 273.026 335.191 1.00 50.92  ? 191 PRO A CG  1 
ATOM 1002 C CD  . PRO A 1 191 ? 203.985 273.741 334.086 1.00 52.27  ? 191 PRO A CD  1 
ATOM 1003 N N   . ALA A 1 192 ? 207.390 270.993 335.897 1.00 54.18  ? 192 ALA A N   1 
ATOM 1004 C CA  . ALA A 1 192 ? 208.337 269.939 335.583 1.00 51.29  ? 192 ALA A CA  1 
ATOM 1005 C C   . ALA A 1 192 ? 207.595 268.720 335.047 1.00 49.47  ? 192 ALA A C   1 
ATOM 1006 O O   . ALA A 1 192 ? 206.371 268.625 335.115 1.00 59.44  ? 192 ALA A O   1 
ATOM 1007 C CB  . ALA A 1 192 ? 209.149 269.568 336.821 1.00 53.09  ? 192 ALA A CB  1 
ATOM 1008 N N   . ARG A 1 193 ? 208.351 267.777 334.493 1.00 40.49  ? 193 ARG A N   1 
ATOM 1009 C CA  . ARG A 1 193 ? 207.726 266.604 333.902 1.00 43.53  ? 193 ARG A CA  1 
ATOM 1010 C C   . ARG A 1 193 ? 208.744 265.526 333.563 1.00 53.41  ? 193 ARG A C   1 
ATOM 1011 O O   . ARG A 1 193 ? 209.772 265.804 332.938 1.00 56.59  ? 193 ARG A O   1 
ATOM 1012 C CB  . ARG A 1 193 ? 206.958 267.003 332.645 1.00 47.33  ? 193 ARG A CB  1 
ATOM 1013 C CG  . ARG A 1 193 ? 206.008 265.947 332.130 1.00 42.42  ? 193 ARG A CG  1 
ATOM 1014 C CD  . ARG A 1 193 ? 205.412 266.386 330.811 1.00 49.28  ? 193 ARG A CD  1 
ATOM 1015 N NE  . ARG A 1 193 ? 204.117 265.769 330.558 1.00 52.72  ? 193 ARG A NE  1 
ATOM 1016 C CZ  . ARG A 1 193 ? 202.968 266.226 331.035 1.00 53.01  ? 193 ARG A CZ  1 
ATOM 1017 N NH1 . ARG A 1 193 ? 202.918 267.289 331.821 1.00 45.96  ? 193 ARG A NH1 1 
ATOM 1018 N NH2 . ARG A 1 193 ? 201.839 265.599 330.717 1.00 55.37  ? 193 ARG A NH2 1 
ATOM 1019 N N   . ILE A 1 194 ? 208.454 264.291 333.963 1.00 54.54  ? 194 ILE A N   1 
ATOM 1020 C CA  . ILE A 1 194 ? 209.240 263.122 333.616 1.00 48.72  ? 194 ILE A CA  1 
ATOM 1021 C C   . ILE A 1 194 ? 208.277 262.019 333.193 1.00 48.40  ? 194 ILE A C   1 
ATOM 1022 O O   . ILE A 1 194 ? 207.063 262.205 333.179 1.00 55.31  ? 194 ILE A O   1 
ATOM 1023 C CB  . ILE A 1 194 ? 210.139 262.654 334.777 1.00 49.65  ? 194 ILE A CB  1 
ATOM 1024 C CG1 . ILE A 1 194 ? 209.303 262.379 336.024 1.00 53.02  ? 194 ILE A CG1 1 
ATOM 1025 C CG2 . ILE A 1 194 ? 211.180 263.694 335.085 1.00 45.90  ? 194 ILE A CG2 1 
ATOM 1026 C CD1 . ILE A 1 194 ? 210.129 262.059 337.241 1.00 50.40  ? 194 ILE A CD1 1 
ATOM 1027 N N   . SER A 1 195 ? 208.832 260.861 332.842 1.00 46.22  ? 195 SER A N   1 
ATOM 1028 C CA  . SER A 1 195 ? 208.002 259.720 332.455 1.00 50.55  ? 195 SER A CA  1 
ATOM 1029 C C   . SER A 1 195 ? 208.754 258.450 332.848 1.00 51.58  ? 195 SER A C   1 
ATOM 1030 O O   . SER A 1 195 ? 209.563 257.929 332.079 1.00 54.17  ? 195 SER A O   1 
ATOM 1031 C CB  . SER A 1 195 ? 207.682 259.744 330.970 1.00 55.27  ? 195 SER A CB  1 
ATOM 1032 O OG  . SER A 1 195 ? 208.849 259.548 330.197 1.00 66.88  ? 195 SER A OG  1 
ATOM 1033 N N   . VAL A 1 196 ? 208.456 257.950 334.041 1.00 46.83  ? 196 VAL A N   1 
ATOM 1034 C CA  . VAL A 1 196 ? 209.097 256.746 334.556 1.00 42.02  ? 196 VAL A CA  1 
ATOM 1035 C C   . VAL A 1 196 ? 208.618 255.561 333.728 1.00 41.22  ? 196 VAL A C   1 
ATOM 1036 O O   . VAL A 1 196 ? 207.423 255.243 333.758 1.00 54.05  ? 196 VAL A O   1 
ATOM 1037 C CB  . VAL A 1 196 ? 208.767 256.538 336.040 1.00 42.96  ? 196 VAL A CB  1 
ATOM 1038 C CG1 . VAL A 1 196 ? 209.559 255.381 336.597 1.00 49.43  ? 196 VAL A CG1 1 
ATOM 1039 C CG2 . VAL A 1 196 ? 209.027 257.808 336.827 1.00 43.54  ? 196 VAL A CG2 1 
ATOM 1040 N N   . PRO A 1 197 ? 209.489 254.855 333.017 1.00 43.46  ? 197 PRO A N   1 
ATOM 1041 C CA  . PRO A 1 197 ? 209.008 253.739 332.195 1.00 47.68  ? 197 PRO A CA  1 
ATOM 1042 C C   . PRO A 1 197 ? 208.536 252.583 333.057 1.00 51.36  ? 197 PRO A C   1 
ATOM 1043 O O   . PRO A 1 197 ? 208.600 252.666 334.286 1.00 52.98  ? 197 PRO A O   1 
ATOM 1044 C CB  . PRO A 1 197 ? 210.237 253.365 331.362 1.00 48.74  ? 197 PRO A CB  1 
ATOM 1045 C CG  . PRO A 1 197 ? 211.385 253.772 332.203 1.00 50.91  ? 197 PRO A CG  1 
ATOM 1046 C CD  . PRO A 1 197 ? 210.949 255.012 332.924 1.00 51.86  ? 197 PRO A CD  1 
ATOM 1047 N N   . TYR A 1 198 ? 208.070 251.502 332.441 1.00 49.19  ? 198 TYR A N   1 
ATOM 1048 C CA  . TYR A 1 198 ? 207.628 250.343 333.209 1.00 45.55  ? 198 TYR A CA  1 
ATOM 1049 C C   . TYR A 1 198 ? 208.833 249.779 333.945 1.00 43.45  ? 198 TYR A C   1 
ATOM 1050 O O   . TYR A 1 198 ? 209.639 249.042 333.375 1.00 50.81  ? 198 TYR A O   1 
ATOM 1051 C CB  . TYR A 1 198 ? 206.999 249.293 332.302 1.00 46.70  ? 198 TYR A CB  1 
ATOM 1052 C CG  . TYR A 1 198 ? 206.732 247.986 333.008 1.00 42.73  ? 198 TYR A CG  1 
ATOM 1053 C CD1 . TYR A 1 198 ? 206.378 247.959 334.348 1.00 43.25  ? 198 TYR A CD1 1 
ATOM 1054 C CD2 . TYR A 1 198 ? 206.851 246.780 332.342 1.00 45.44  ? 198 TYR A CD2 1 
ATOM 1055 C CE1 . TYR A 1 198 ? 206.144 246.773 334.998 1.00 48.18  ? 198 TYR A CE1 1 
ATOM 1056 C CE2 . TYR A 1 198 ? 206.619 245.589 332.986 1.00 47.25  ? 198 TYR A CE2 1 
ATOM 1057 C CZ  . TYR A 1 198 ? 206.267 245.592 334.314 1.00 50.26  ? 198 TYR A CZ  1 
ATOM 1058 O OH  . TYR A 1 198 ? 206.032 244.407 334.966 1.00 54.35  ? 198 TYR A OH  1 
ATOM 1059 N N   . VAL A 1 199 ? 208.952 250.117 335.220 1.00 37.50  ? 199 VAL A N   1 
ATOM 1060 C CA  . VAL A 1 199 ? 210.097 249.739 336.036 1.00 43.33  ? 199 VAL A CA  1 
ATOM 1061 C C   . VAL A 1 199 ? 209.612 248.686 337.023 1.00 42.23  ? 199 VAL A C   1 
ATOM 1062 O O   . VAL A 1 199 ? 208.998 249.003 338.047 1.00 46.14  ? 199 VAL A O   1 
ATOM 1063 C CB  . VAL A 1 199 ? 210.719 250.948 336.744 1.00 44.63  ? 199 VAL A CB  1 
ATOM 1064 C CG1 . VAL A 1 199 ? 209.730 251.597 337.701 1.00 40.05  ? 199 VAL A CG1 1 
ATOM 1065 C CG2 . VAL A 1 199 ? 211.984 250.538 337.473 1.00 49.15  ? 199 VAL A CG2 1 
ATOM 1066 N N   . GLY A 1 200 ? 209.880 247.423 336.714 1.00 50.57  ? 200 GLY A N   1 
ATOM 1067 C CA  . GLY A 1 200 ? 209.475 246.337 337.584 1.00 58.43  ? 200 GLY A CA  1 
ATOM 1068 C C   . GLY A 1 200 ? 210.222 245.074 337.237 1.00 57.08  ? 200 GLY A C   1 
ATOM 1069 O O   . GLY A 1 200 ? 210.606 244.858 336.084 1.00 53.72  ? 200 GLY A O   1 
ATOM 1070 N N   . ILE A 1 201 ? 210.430 244.230 338.247 1.00 51.40  ? 201 ILE A N   1 
ATOM 1071 C CA  . ILE A 1 201 ? 211.158 242.985 338.029 1.00 48.46  ? 201 ILE A CA  1 
ATOM 1072 C C   . ILE A 1 201 ? 210.297 242.002 337.248 1.00 52.45  ? 201 ILE A C   1 
ATOM 1073 O O   . ILE A 1 201 ? 210.740 241.415 336.255 1.00 49.98  ? 201 ILE A O   1 
ATOM 1074 C CB  . ILE A 1 201 ? 211.613 242.383 339.369 1.00 49.32  ? 201 ILE A CB  1 
ATOM 1075 C CG1 . ILE A 1 201 ? 212.260 243.446 340.254 1.00 59.10  ? 201 ILE A CG1 1 
ATOM 1076 C CG2 . ILE A 1 201 ? 212.602 241.261 339.125 1.00 54.18  ? 201 ILE A CG2 1 
ATOM 1077 C CD1 . ILE A 1 201 ? 212.702 242.919 341.598 1.00 59.99  ? 201 ILE A CD1 1 
ATOM 1078 N N   . SER A 1 202 ? 209.053 241.815 337.683 1.00 51.63  ? 202 SER A N   1 
ATOM 1079 C CA  . SER A 1 202 ? 208.150 240.883 337.030 1.00 46.35  ? 202 SER A CA  1 
ATOM 1080 C C   . SER A 1 202 ? 207.719 241.436 335.676 1.00 47.45  ? 202 SER A C   1 
ATOM 1081 O O   . SER A 1 202 ? 208.115 242.527 335.261 1.00 60.24  ? 202 SER A O   1 
ATOM 1082 C CB  . SER A 1 202 ? 206.941 240.612 337.917 1.00 51.06  ? 202 SER A CB  1 
ATOM 1083 O OG  . SER A 1 202 ? 207.347 240.153 339.192 1.00 56.14  ? 202 SER A OG  1 
ATOM 1084 N N   . ASN A 1 203 ? 206.891 240.669 334.976 1.00 36.10  ? 203 ASN A N   1 
ATOM 1085 C CA  . ASN A 1 203 ? 206.416 241.049 333.655 1.00 42.40  ? 203 ASN A CA  1 
ATOM 1086 C C   . ASN A 1 203 ? 205.091 241.793 333.699 1.00 50.17  ? 203 ASN A C   1 
ATOM 1087 O O   . ASN A 1 203 ? 204.514 242.068 332.643 1.00 46.66  ? 203 ASN A O   1 
ATOM 1088 C CB  . ASN A 1 203 ? 206.294 239.811 332.772 1.00 39.44  ? 203 ASN A CB  1 
ATOM 1089 C CG  . ASN A 1 203 ? 207.628 239.152 332.518 1.00 49.49  ? 203 ASN A CG  1 
ATOM 1090 O OD1 . ASN A 1 203 ? 208.010 238.206 333.204 1.00 56.38  ? 203 ASN A OD1 1 
ATOM 1091 N ND2 . ASN A 1 203 ? 208.352 239.656 331.530 1.00 56.67  ? 203 ASN A ND2 1 
ATOM 1092 N N   . ALA A 1 204 ? 204.594 242.116 334.889 1.00 45.18  ? 204 ALA A N   1 
ATOM 1093 C CA  . ALA A 1 204 ? 203.379 242.902 335.035 1.00 34.03  ? 204 ALA A CA  1 
ATOM 1094 C C   . ALA A 1 204 ? 203.180 243.199 336.509 1.00 34.95  ? 204 ALA A C   1 
ATOM 1095 O O   . ALA A 1 204 ? 203.401 242.327 337.350 1.00 48.71  ? 204 ALA A O   1 
ATOM 1096 C CB  . ALA A 1 204 ? 202.163 242.159 334.475 1.00 32.42  ? 204 ALA A CB  1 
ATOM 1097 N N   . TYR A 1 205 ? 202.769 244.424 336.818 1.00 29.07  ? 205 TYR A N   1 
ATOM 1098 C CA  . TYR A 1 205 ? 202.463 244.748 338.200 1.00 33.85  ? 205 TYR A CA  1 
ATOM 1099 C C   . TYR A 1 205 ? 201.398 243.792 338.720 1.00 44.00  ? 205 TYR A C   1 
ATOM 1100 O O   . TYR A 1 205 ? 200.654 243.176 337.956 1.00 51.03  ? 205 TYR A O   1 
ATOM 1101 C CB  . TYR A 1 205 ? 201.977 246.188 338.331 1.00 42.36  ? 205 TYR A CB  1 
ATOM 1102 C CG  . TYR A 1 205 ? 202.981 247.229 337.898 1.00 48.12  ? 205 TYR A CG  1 
ATOM 1103 C CD1 . TYR A 1 205 ? 203.962 247.679 338.766 1.00 46.23  ? 205 TYR A CD1 1 
ATOM 1104 C CD2 . TYR A 1 205 ? 202.937 247.774 336.627 1.00 47.17  ? 205 TYR A CD2 1 
ATOM 1105 C CE1 . TYR A 1 205 ? 204.874 248.632 338.373 1.00 44.78  ? 205 TYR A CE1 1 
ATOM 1106 C CE2 . TYR A 1 205 ? 203.841 248.726 336.229 1.00 41.66  ? 205 TYR A CE2 1 
ATOM 1107 C CZ  . TYR A 1 205 ? 204.807 249.152 337.104 1.00 46.42  ? 205 TYR A CZ  1 
ATOM 1108 O OH  . TYR A 1 205 ? 205.710 250.105 336.703 1.00 53.52  ? 205 TYR A OH  1 
ATOM 1109 N N   . SER A 1 206 ? 201.335 243.660 340.041 1.00 45.35  ? 206 SER A N   1 
ATOM 1110 C CA  . SER A 1 206 ? 200.358 242.788 340.678 1.00 43.34  ? 206 SER A CA  1 
ATOM 1111 C C   . SER A 1 206 ? 199.729 243.537 341.836 1.00 47.14  ? 206 SER A C   1 
ATOM 1112 O O   . SER A 1 206 ? 200.422 243.900 342.789 1.00 54.03  ? 206 SER A O   1 
ATOM 1113 C CB  . SER A 1 206 ? 201.004 241.492 341.169 1.00 51.77  ? 206 SER A CB  1 
ATOM 1114 O OG  . SER A 1 206 ? 201.452 240.708 340.080 1.00 57.57  ? 206 SER A OG  1 
ATOM 1115 N N   . HIS A 1 207 ? 198.422 243.767 341.753 1.00 45.17  ? 207 HIS A N   1 
ATOM 1116 C CA  . HIS A 1 207 ? 197.708 244.440 342.824 1.00 50.14  ? 207 HIS A CA  1 
ATOM 1117 C C   . HIS A 1 207 ? 197.228 243.476 343.896 1.00 52.22  ? 207 HIS A C   1 
ATOM 1118 O O   . HIS A 1 207 ? 196.968 243.905 345.026 1.00 49.94  ? 207 HIS A O   1 
ATOM 1119 C CB  . HIS A 1 207 ? 196.518 245.212 342.253 1.00 46.82  ? 207 HIS A CB  1 
ATOM 1120 C CG  . HIS A 1 207 ? 196.775 245.784 340.896 1.00 41.87  ? 207 HIS A CG  1 
ATOM 1121 N ND1 . HIS A 1 207 ? 196.335 245.178 339.741 1.00 47.87  ? 207 HIS A ND1 1 
ATOM 1122 C CD2 . HIS A 1 207 ? 197.443 246.895 340.508 1.00 45.73  ? 207 HIS A CD2 1 
ATOM 1123 C CE1 . HIS A 1 207 ? 196.711 245.897 338.699 1.00 44.00  ? 207 HIS A CE1 1 
ATOM 1124 N NE2 . HIS A 1 207 ? 197.387 246.942 339.137 1.00 44.18  ? 207 HIS A NE2 1 
ATOM 1125 N N   . PHE A 1 208 ? 197.115 242.190 343.570 1.00 60.36  ? 208 PHE A N   1 
ATOM 1126 C CA  . PHE A 1 208 ? 196.733 241.158 344.525 1.00 55.57  ? 208 PHE A CA  1 
ATOM 1127 C C   . PHE A 1 208 ? 197.725 240.012 344.410 1.00 55.33  ? 208 PHE A C   1 
ATOM 1128 O O   . PHE A 1 208 ? 197.846 239.400 343.345 1.00 57.22  ? 208 PHE A O   1 
ATOM 1129 C CB  . PHE A 1 208 ? 195.309 240.665 344.264 1.00 49.95  ? 208 PHE A CB  1 
ATOM 1130 C CG  . PHE A 1 208 ? 194.287 241.759 344.260 1.00 56.65  ? 208 PHE A CG  1 
ATOM 1131 C CD1 . PHE A 1 208 ? 193.730 242.208 345.442 1.00 58.96  ? 208 PHE A CD1 1 
ATOM 1132 C CD2 . PHE A 1 208 ? 193.886 242.343 343.074 1.00 52.25  ? 208 PHE A CD2 1 
ATOM 1133 C CE1 . PHE A 1 208 ? 192.793 243.215 345.440 1.00 54.57  ? 208 PHE A CE1 1 
ATOM 1134 C CE2 . PHE A 1 208 ? 192.951 243.349 343.068 1.00 50.84  ? 208 PHE A CE2 1 
ATOM 1135 C CZ  . PHE A 1 208 ? 192.403 243.785 344.252 1.00 52.82  ? 208 PHE A CZ  1 
ATOM 1136 N N   . TYR A 1 209 ? 198.429 239.727 345.500 1.00 66.83  ? 209 TYR A N   1 
ATOM 1137 C CA  . TYR A 1 209 ? 199.408 238.653 345.551 1.00 69.04  ? 209 TYR A CA  1 
ATOM 1138 C C   . TYR A 1 209 ? 198.907 237.575 346.500 1.00 76.10  ? 209 TYR A C   1 
ATOM 1139 O O   . TYR A 1 209 ? 198.600 237.860 347.662 1.00 73.49  ? 209 TYR A O   1 
ATOM 1140 C CB  . TYR A 1 209 ? 200.768 239.180 346.008 1.00 75.29  ? 209 TYR A CB  1 
ATOM 1141 C CG  . TYR A 1 209 ? 201.929 238.254 345.723 1.00 74.58  ? 209 TYR A CG  1 
ATOM 1142 C CD1 . TYR A 1 209 ? 202.368 238.038 344.425 1.00 73.60  ? 209 TYR A CD1 1 
ATOM 1143 C CD2 . TYR A 1 209 ? 202.597 237.611 346.754 1.00 72.50  ? 209 TYR A CD2 1 
ATOM 1144 C CE1 . TYR A 1 209 ? 203.430 237.199 344.163 1.00 73.71  ? 209 TYR A CE1 1 
ATOM 1145 C CE2 . TYR A 1 209 ? 203.659 236.771 346.501 1.00 72.76  ? 209 TYR A CE2 1 
ATOM 1146 C CZ  . TYR A 1 209 ? 204.072 236.569 345.205 1.00 75.07  ? 209 TYR A CZ  1 
ATOM 1147 O OH  . TYR A 1 209 ? 205.133 235.732 344.952 1.00 75.19  ? 209 TYR A OH  1 
ATOM 1148 N N   . ASP A 1 210 ? 198.815 236.347 346.000 1.00 94.19  ? 210 ASP A N   1 
ATOM 1149 C CA  . ASP A 1 210 ? 198.349 235.215 346.787 1.00 90.04  ? 210 ASP A CA  1 
ATOM 1150 C C   . ASP A 1 210 ? 199.487 234.452 347.448 1.00 91.10  ? 210 ASP A C   1 
ATOM 1151 O O   . ASP A 1 210 ? 199.229 233.487 348.173 1.00 91.43  ? 210 ASP A O   1 
ATOM 1152 C CB  . ASP A 1 210 ? 197.543 234.265 345.900 1.00 94.11  ? 210 ASP A CB  1 
ATOM 1153 C CG  . ASP A 1 210 ? 196.538 233.449 346.681 1.00 95.38  ? 210 ASP A CG  1 
ATOM 1154 O OD1 . ASP A 1 210 ? 196.823 233.100 347.844 1.00 96.17  ? 210 ASP A OD1 1 
ATOM 1155 O OD2 . ASP A 1 210 ? 195.454 233.160 346.132 1.00 93.93  ? 210 ASP A OD2 1 
ATOM 1156 N N   . GLY A 1 211 ? 200.734 234.855 347.216 1.00 95.04  ? 211 GLY A N   1 
ATOM 1157 C CA  . GLY A 1 211 ? 201.879 234.189 347.793 1.00 92.86  ? 211 GLY A CA  1 
ATOM 1158 C C   . GLY A 1 211 ? 202.313 234.822 349.100 1.00 95.37  ? 211 GLY A C   1 
ATOM 1159 O O   . GLY A 1 211 ? 201.660 235.709 349.652 1.00 95.76  ? 211 GLY A O   1 
ATOM 1160 N N   . PHE A 1 212 ? 203.449 234.341 349.600 1.00 99.55  ? 212 PHE A N   1 
ATOM 1161 C CA  . PHE A 1 212 ? 204.017 234.814 350.851 1.00 100.25 ? 212 PHE A CA  1 
ATOM 1162 C C   . PHE A 1 212 ? 205.516 235.004 350.684 1.00 100.05 ? 212 PHE A C   1 
ATOM 1163 O O   . PHE A 1 212 ? 206.146 234.371 349.833 1.00 98.71  ? 212 PHE A O   1 
ATOM 1164 C CB  . PHE A 1 212 ? 203.748 233.835 352.000 1.00 98.29  ? 212 PHE A CB  1 
ATOM 1165 C CG  . PHE A 1 212 ? 202.354 233.907 352.542 1.00 99.93  ? 212 PHE A CG  1 
ATOM 1166 C CD1 . PHE A 1 212 ? 201.301 233.327 351.860 1.00 99.68  ? 212 PHE A CD1 1 
ATOM 1167 C CD2 . PHE A 1 212 ? 202.098 234.552 353.737 1.00 99.86  ? 212 PHE A CD2 1 
ATOM 1168 C CE1 . PHE A 1 212 ? 200.015 233.393 352.359 1.00 98.94  ? 212 PHE A CE1 1 
ATOM 1169 C CE2 . PHE A 1 212 ? 200.818 234.621 354.241 1.00 100.15 ? 212 PHE A CE2 1 
ATOM 1170 C CZ  . PHE A 1 212 ? 199.774 234.041 353.552 1.00 99.55  ? 212 PHE A CZ  1 
ATOM 1171 N N   . SER A 1 213 ? 206.077 235.886 351.503 1.00 106.22 ? 213 SER A N   1 
ATOM 1172 C CA  . SER A 1 213 ? 207.522 236.049 351.542 1.00 106.04 ? 213 SER A CA  1 
ATOM 1173 C C   . SER A 1 213 ? 208.170 234.788 352.097 1.00 105.37 ? 213 SER A C   1 
ATOM 1174 O O   . SER A 1 213 ? 207.653 234.162 353.025 1.00 107.76 ? 213 SER A O   1 
ATOM 1175 C CB  . SER A 1 213 ? 207.897 237.257 352.398 1.00 106.82 ? 213 SER A CB  1 
ATOM 1176 O OG  . SER A 1 213 ? 207.288 238.437 351.904 1.00 104.12 ? 213 SER A OG  1 
ATOM 1177 N N   . LYS A 1 214 ? 209.305 234.414 351.519 1.00 111.02 ? 214 LYS A N   1 
ATOM 1178 C CA  . LYS A 1 214 ? 210.005 233.199 351.921 1.00 113.75 ? 214 LYS A CA  1 
ATOM 1179 C C   . LYS A 1 214 ? 209.107 231.976 351.759 1.00 114.78 ? 214 LYS A C   1 
ATOM 1180 O O   . LYS A 1 214 ? 208.348 231.622 352.662 1.00 114.00 ? 214 LYS A O   1 
ATOM 1181 C CB  . LYS A 1 214 ? 210.491 233.310 353.370 1.00 113.86 ? 214 LYS A CB  1 
ATOM 1182 C CG  . LYS A 1 214 ? 211.171 232.052 353.906 1.00 114.02 ? 214 LYS A CG  1 
ATOM 1183 C CD  . LYS A 1 214 ? 212.251 231.523 352.966 1.00 115.39 ? 214 LYS A CD  1 
ATOM 1184 C CE  . LYS A 1 214 ? 213.316 232.568 352.664 1.00 114.60 ? 214 LYS A CE  1 
ATOM 1185 N NZ  . LYS A 1 214 ? 214.361 232.046 351.742 1.00 112.39 ? 214 LYS A NZ  1 
ATOM 1186 N N   . SER A 1 233 ? 202.233 242.145 345.239 1.00 73.88  ? 233 SER A N   1 
ATOM 1187 C CA  . SER A 1 233 ? 201.760 243.437 345.712 1.00 76.33  ? 233 SER A CA  1 
ATOM 1188 C C   . SER A 1 233 ? 202.925 244.261 346.236 1.00 81.57  ? 233 SER A C   1 
ATOM 1189 O O   . SER A 1 233 ? 204.062 243.789 346.282 1.00 76.34  ? 233 SER A O   1 
ATOM 1190 C CB  . SER A 1 233 ? 200.702 243.259 346.801 1.00 75.52  ? 233 SER A CB  1 
ATOM 1191 O OG  . SER A 1 233 ? 201.216 242.520 347.893 1.00 76.50  ? 233 SER A OG  1 
ATOM 1192 N N   . LEU A 1 234 ? 202.634 245.497 346.635 1.00 87.31  ? 234 LEU A N   1 
ATOM 1193 C CA  . LEU A 1 234 ? 203.662 246.423 347.100 1.00 87.71  ? 234 LEU A CA  1 
ATOM 1194 C C   . LEU A 1 234 ? 204.772 246.560 346.062 1.00 85.93  ? 234 LEU A C   1 
ATOM 1195 O O   . LEU A 1 234 ? 205.961 246.572 346.387 1.00 85.12  ? 234 LEU A O   1 
ATOM 1196 C CB  . LEU A 1 234 ? 204.226 245.976 348.448 1.00 88.83  ? 234 LEU A CB  1 
ATOM 1197 C CG  . LEU A 1 234 ? 203.194 245.831 349.566 1.00 87.59  ? 234 LEU A CG  1 
ATOM 1198 C CD1 . LEU A 1 234 ? 203.861 245.384 350.857 1.00 83.01  ? 234 LEU A CD1 1 
ATOM 1199 C CD2 . LEU A 1 234 ? 202.441 247.135 349.772 1.00 83.37  ? 234 LEU A CD2 1 
ATOM 1200 N N   . ASN A 1 235 ? 204.377 246.654 344.796 1.00 71.26  ? 235 ASN A N   1 
ATOM 1201 C CA  . ASN A 1 235 ? 205.345 246.885 343.735 1.00 65.89  ? 235 ASN A CA  1 
ATOM 1202 C C   . ASN A 1 235 ? 206.070 248.198 343.986 1.00 64.91  ? 235 ASN A C   1 
ATOM 1203 O O   . ASN A 1 235 ? 205.460 249.195 344.378 1.00 66.94  ? 235 ASN A O   1 
ATOM 1204 C CB  . ASN A 1 235 ? 204.649 246.921 342.375 1.00 67.89  ? 235 ASN A CB  1 
ATOM 1205 C CG  . ASN A 1 235 ? 203.727 245.742 342.162 1.00 72.45  ? 235 ASN A CG  1 
ATOM 1206 O OD1 . ASN A 1 235 ? 204.175 244.634 341.871 1.00 69.91  ? 235 ASN A OD1 1 
ATOM 1207 N ND2 . ASN A 1 235 ? 202.427 245.976 342.300 1.00 66.96  ? 235 ASN A ND2 1 
ATOM 1208 N N   . ASP A 1 236 ? 207.380 248.197 343.764 1.00 59.72  ? 236 ASP A N   1 
ATOM 1209 C CA  . ASP A 1 236 ? 208.211 249.365 344.025 1.00 58.04  ? 236 ASP A CA  1 
ATOM 1210 C C   . ASP A 1 236 ? 208.354 250.152 342.729 1.00 60.16  ? 236 ASP A C   1 
ATOM 1211 O O   . ASP A 1 236 ? 208.950 249.667 341.763 1.00 57.56  ? 236 ASP A O   1 
ATOM 1212 C CB  . ASP A 1 236 ? 209.575 248.954 344.574 1.00 60.19  ? 236 ASP A CB  1 
ATOM 1213 C CG  . ASP A 1 236 ? 210.234 250.058 345.381 1.00 66.37  ? 236 ASP A CG  1 
ATOM 1214 O OD1 . ASP A 1 236 ? 209.644 251.152 345.488 1.00 69.42  ? 236 ASP A OD1 1 
ATOM 1215 O OD2 . ASP A 1 236 ? 211.339 249.832 345.914 1.00 58.98  ? 236 ASP A OD2 1 
ATOM 1216 N N   . PHE A 1 237 ? 207.799 251.364 342.710 1.00 53.48  ? 237 PHE A N   1 
ATOM 1217 C CA  . PHE A 1 237 ? 207.919 252.246 341.559 1.00 55.99  ? 237 PHE A CA  1 
ATOM 1218 C C   . PHE A 1 237 ? 209.077 253.221 341.686 1.00 51.11  ? 237 PHE A C   1 
ATOM 1219 O O   . PHE A 1 237 ? 209.533 253.757 340.671 1.00 55.32  ? 237 PHE A O   1 
ATOM 1220 C CB  . PHE A 1 237 ? 206.629 253.043 341.360 1.00 54.25  ? 237 PHE A CB  1 
ATOM 1221 C CG  . PHE A 1 237 ? 205.386 252.206 341.373 1.00 57.88  ? 237 PHE A CG  1 
ATOM 1222 C CD1 . PHE A 1 237 ? 204.744 251.922 342.562 1.00 59.80  ? 237 PHE A CD1 1 
ATOM 1223 C CD2 . PHE A 1 237 ? 204.851 251.718 340.197 1.00 56.21  ? 237 PHE A CD2 1 
ATOM 1224 C CE1 . PHE A 1 237 ? 203.600 251.158 342.578 1.00 55.68  ? 237 PHE A CE1 1 
ATOM 1225 C CE2 . PHE A 1 237 ? 203.706 250.957 340.209 1.00 52.98  ? 237 PHE A CE2 1 
ATOM 1226 C CZ  . PHE A 1 237 ? 203.081 250.676 341.399 1.00 53.18  ? 237 PHE A CZ  1 
ATOM 1227 N N   . GLY A 1 238 ? 209.557 253.466 342.901 1.00 41.34  ? 238 GLY A N   1 
ATOM 1228 C CA  . GLY A 1 238 ? 210.653 254.368 343.154 1.00 43.51  ? 238 GLY A CA  1 
ATOM 1229 C C   . GLY A 1 238 ? 210.317 255.293 344.297 1.00 46.38  ? 238 GLY A C   1 
ATOM 1230 O O   . GLY A 1 238 ? 209.462 254.992 345.135 1.00 55.52  ? 238 GLY A O   1 
ATOM 1231 N N   . ILE A 1 239 ? 211.012 256.429 344.334 1.00 41.92  ? 239 ILE A N   1 
ATOM 1232 C CA  . ILE A 1 239 ? 210.772 257.469 345.324 1.00 45.56  ? 239 ILE A CA  1 
ATOM 1233 C C   . ILE A 1 239 ? 211.001 258.807 344.640 1.00 49.14  ? 239 ILE A C   1 
ATOM 1234 O O   . ILE A 1 239 ? 211.707 258.898 343.639 1.00 56.33  ? 239 ILE A O   1 
ATOM 1235 C CB  . ILE A 1 239 ? 211.690 257.319 346.562 1.00 52.12  ? 239 ILE A CB  1 
ATOM 1236 C CG1 . ILE A 1 239 ? 211.399 256.009 347.293 1.00 50.43  ? 239 ILE A CG1 1 
ATOM 1237 C CG2 . ILE A 1 239 ? 211.531 258.496 347.506 1.00 52.38  ? 239 ILE A CG2 1 
ATOM 1238 C CD1 . ILE A 1 239 ? 212.262 254.857 346.842 1.00 53.97  ? 239 ILE A CD1 1 
ATOM 1239 N N   . LEU A 1 240 ? 210.386 259.854 345.181 1.00 54.79  ? 240 LEU A N   1 
ATOM 1240 C CA  . LEU A 1 240 ? 210.610 261.222 344.734 1.00 52.49  ? 240 LEU A CA  1 
ATOM 1241 C C   . LEU A 1 240 ? 211.065 262.036 345.932 1.00 54.18  ? 240 LEU A C   1 
ATOM 1242 O O   . LEU A 1 240 ? 210.365 262.089 346.948 1.00 65.23  ? 240 LEU A O   1 
ATOM 1243 C CB  . LEU A 1 240 ? 209.343 261.824 344.130 1.00 44.95  ? 240 LEU A CB  1 
ATOM 1244 C CG  . LEU A 1 240 ? 208.828 261.135 342.871 1.00 47.96  ? 240 LEU A CG  1 
ATOM 1245 C CD1 . LEU A 1 240 ? 207.414 261.576 342.572 1.00 54.21  ? 240 LEU A CD1 1 
ATOM 1246 C CD2 . LEU A 1 240 ? 209.733 261.433 341.695 1.00 50.19  ? 240 LEU A CD2 1 
ATOM 1247 N N   . ALA A 1 241 ? 212.229 262.664 345.818 1.00 35.72  ? 241 ALA A N   1 
ATOM 1248 C CA  . ALA A 1 241 ? 212.772 263.493 346.882 1.00 47.91  ? 241 ALA A CA  1 
ATOM 1249 C C   . ALA A 1 241 ? 213.013 264.888 346.334 1.00 54.78  ? 241 ALA A C   1 
ATOM 1250 O O   . ALA A 1 241 ? 213.719 265.051 345.337 1.00 57.65  ? 241 ALA A O   1 
ATOM 1251 C CB  . ALA A 1 241 ? 214.067 262.898 347.435 1.00 63.14  ? 241 ALA A CB  1 
ATOM 1252 N N   . VAL A 1 242 ? 212.434 265.889 346.982 1.00 54.23  ? 242 VAL A N   1 
ATOM 1253 C CA  . VAL A 1 242 ? 212.484 267.261 346.501 1.00 49.43  ? 242 VAL A CA  1 
ATOM 1254 C C   . VAL A 1 242 ? 213.065 268.144 347.591 1.00 55.01  ? 242 VAL A C   1 
ATOM 1255 O O   . VAL A 1 242 ? 212.716 268.004 348.768 1.00 60.46  ? 242 VAL A O   1 
ATOM 1256 C CB  . VAL A 1 242 ? 211.091 267.764 346.077 1.00 51.68  ? 242 VAL A CB  1 
ATOM 1257 C CG1 . VAL A 1 242 ? 211.189 269.158 345.499 1.00 57.53  ? 242 VAL A CG1 1 
ATOM 1258 C CG2 . VAL A 1 242 ? 210.475 266.814 345.069 1.00 55.21  ? 242 VAL A CG2 1 
ATOM 1259 N N   . ARG A 1 243 ? 213.961 269.047 347.199 1.00 60.13  ? 243 ARG A N   1 
ATOM 1260 C CA  . ARG A 1 243 ? 214.547 269.995 348.138 1.00 61.03  ? 243 ARG A CA  1 
ATOM 1261 C C   . ARG A 1 243 ? 214.807 271.310 347.421 1.00 64.70  ? 243 ARG A C   1 
ATOM 1262 O O   . ARG A 1 243 ? 214.641 271.421 346.207 1.00 68.82  ? 243 ARG A O   1 
ATOM 1263 C CB  . ARG A 1 243 ? 215.843 269.463 348.745 1.00 64.11  ? 243 ARG A CB  1 
ATOM 1264 C CG  . ARG A 1 243 ? 217.049 269.619 347.842 1.00 61.38  ? 243 ARG A CG  1 
ATOM 1265 C CD  . ARG A 1 243 ? 218.202 268.786 348.342 1.00 61.41  ? 243 ARG A CD  1 
ATOM 1266 N NE  . ARG A 1 243 ? 219.331 268.794 347.420 1.00 60.58  ? 243 ARG A NE  1 
ATOM 1267 C CZ  . ARG A 1 243 ? 220.427 269.523 347.569 1.00 65.59  ? 243 ARG A CZ  1 
ATOM 1268 N NH1 . ARG A 1 243 ? 220.582 270.343 348.596 1.00 70.41  ? 243 ARG A NH1 1 
ATOM 1269 N NH2 . ARG A 1 243 ? 221.398 269.423 346.667 1.00 65.57  ? 243 ARG A NH2 1 
ATOM 1270 N N   . VAL A 1 244 ? 215.233 272.308 348.189 1.00 69.82  ? 244 VAL A N   1 
ATOM 1271 C CA  . VAL A 1 244 ? 215.531 273.639 347.670 1.00 66.64  ? 244 VAL A CA  1 
ATOM 1272 C C   . VAL A 1 244 ? 217.043 273.794 347.616 1.00 71.58  ? 244 VAL A C   1 
ATOM 1273 O O   . VAL A 1 244 ? 217.717 273.782 348.653 1.00 74.41  ? 244 VAL A O   1 
ATOM 1274 C CB  . VAL A 1 244 ? 214.893 274.744 348.525 1.00 71.74  ? 244 VAL A CB  1 
ATOM 1275 C CG1 . VAL A 1 244 ? 213.380 274.645 348.471 1.00 76.45  ? 244 VAL A CG1 1 
ATOM 1276 C CG2 . VAL A 1 244 ? 215.392 274.687 349.965 1.00 71.88  ? 244 VAL A CG2 1 
ATOM 1277 N N   . VAL A 1 245 ? 217.577 273.941 346.405 1.00 66.23  ? 245 VAL A N   1 
ATOM 1278 C CA  . VAL A 1 245 ? 219.021 274.046 346.241 1.00 59.99  ? 245 VAL A CA  1 
ATOM 1279 C C   . VAL A 1 245 ? 219.539 275.339 346.857 1.00 71.88  ? 245 VAL A C   1 
ATOM 1280 O O   . VAL A 1 245 ? 220.646 275.379 347.406 1.00 75.34  ? 245 VAL A O   1 
ATOM 1281 C CB  . VAL A 1 245 ? 219.388 273.939 344.752 1.00 63.41  ? 245 VAL A CB  1 
ATOM 1282 C CG1 . VAL A 1 245 ? 220.879 274.046 344.570 1.00 73.07  ? 245 VAL A CG1 1 
ATOM 1283 C CG2 . VAL A 1 245 ? 218.883 272.632 344.184 1.00 63.67  ? 245 VAL A CG2 1 
ATOM 1284 N N   . ASN A 1 246 ? 218.756 276.413 346.774 1.00 80.91  ? 246 ASN A N   1 
ATOM 1285 C CA  . ASN A 1 246 ? 219.203 277.713 347.256 1.00 75.64  ? 246 ASN A CA  1 
ATOM 1286 C C   . ASN A 1 246 ? 219.700 277.621 348.692 1.00 77.15  ? 246 ASN A C   1 
ATOM 1287 O O   . ASN A 1 246 ? 219.273 276.764 349.470 1.00 80.51  ? 246 ASN A O   1 
ATOM 1288 C CB  . ASN A 1 246 ? 218.064 278.728 347.167 1.00 75.64  ? 246 ASN A CB  1 
ATOM 1289 C CG  . ASN A 1 246 ? 217.585 278.939 345.751 1.00 74.80  ? 246 ASN A CG  1 
ATOM 1290 O OD1 . ASN A 1 246 ? 216.860 278.113 345.201 1.00 74.20  ? 246 ASN A OD1 1 
ATOM 1291 N ND2 . ASN A 1 246 ? 217.985 280.052 345.153 1.00 77.42  ? 246 ASN A ND2 1 
ATOM 1292 N N   . ASP A 1 247 ? 220.613 278.519 349.036 1.00 91.03  ? 247 ASP A N   1 
ATOM 1293 C CA  . ASP A 1 247 ? 221.175 278.587 350.375 1.00 95.61  ? 247 ASP A CA  1 
ATOM 1294 C C   . ASP A 1 247 ? 220.180 279.240 351.325 1.00 98.45  ? 247 ASP A C   1 
ATOM 1295 O O   . ASP A 1 247 ? 219.198 279.850 350.898 1.00 93.21  ? 247 ASP A O   1 
ATOM 1296 C CB  . ASP A 1 247 ? 222.487 279.363 350.341 1.00 96.02  ? 247 ASP A CB  1 
ATOM 1297 C CG  . ASP A 1 247 ? 223.435 278.852 349.279 1.00 96.36  ? 247 ASP A CG  1 
ATOM 1298 O OD1 . ASP A 1 247 ? 223.501 277.620 349.086 1.00 95.29  ? 247 ASP A OD1 1 
ATOM 1299 O OD2 . ASP A 1 247 ? 224.108 279.681 348.631 1.00 96.85  ? 247 ASP A OD2 1 
ATOM 1300 N N   . PRO A 1 248 ? 220.404 279.124 352.633 1.00 106.98 ? 248 PRO A N   1 
ATOM 1301 C CA  . PRO A 1 248 ? 219.458 279.707 353.591 1.00 104.27 ? 248 PRO A CA  1 
ATOM 1302 C C   . PRO A 1 248 ? 219.285 281.203 353.370 1.00 104.22 ? 248 PRO A C   1 
ATOM 1303 O O   . PRO A 1 248 ? 220.237 281.920 353.053 1.00 105.74 ? 248 PRO A O   1 
ATOM 1304 C CB  . PRO A 1 248 ? 220.100 279.410 354.950 1.00 103.43 ? 248 PRO A CB  1 
ATOM 1305 C CG  . PRO A 1 248 ? 221.000 278.254 354.705 1.00 102.88 ? 248 PRO A CG  1 
ATOM 1306 C CD  . PRO A 1 248 ? 221.507 278.420 353.308 1.00 103.04 ? 248 PRO A CD  1 
ATOM 1307 N N   . ASN A 1 249 ? 218.048 281.667 353.540 1.00 111.29 ? 249 ASN A N   1 
ATOM 1308 C CA  . ASN A 1 249 ? 217.694 283.069 353.407 1.00 114.11 ? 249 ASN A CA  1 
ATOM 1309 C C   . ASN A 1 249 ? 216.651 283.376 354.473 1.00 117.04 ? 249 ASN A C   1 
ATOM 1310 O O   . ASN A 1 249 ? 215.761 282.548 354.717 1.00 115.95 ? 249 ASN A O   1 
ATOM 1311 C CB  . ASN A 1 249 ? 217.138 283.382 352.011 1.00 113.18 ? 249 ASN A CB  1 
ATOM 1312 C CG  . ASN A 1 249 ? 216.911 284.861 351.790 1.00 110.83 ? 249 ASN A CG  1 
ATOM 1313 O OD1 . ASN A 1 249 ? 215.873 285.404 352.163 1.00 110.92 ? 249 ASN A OD1 1 
ATOM 1314 N ND2 . ASN A 1 249 ? 217.885 285.524 351.181 1.00 110.87 ? 249 ASN A ND2 1 
ATOM 1315 N N   . PRO A 1 250 ? 216.721 284.544 355.122 1.00 121.76 ? 250 PRO A N   1 
ATOM 1316 C CA  . PRO A 1 250 ? 215.811 284.787 356.263 1.00 121.19 ? 250 PRO A CA  1 
ATOM 1317 C C   . PRO A 1 250 ? 214.401 285.161 355.820 1.00 119.61 ? 250 PRO A C   1 
ATOM 1318 O O   . PRO A 1 250 ? 213.912 286.278 356.020 1.00 117.63 ? 250 PRO A O   1 
ATOM 1319 C CB  . PRO A 1 250 ? 216.522 285.921 357.008 1.00 120.45 ? 250 PRO A CB  1 
ATOM 1320 C CG  . PRO A 1 250 ? 217.207 286.690 355.935 1.00 118.99 ? 250 PRO A CG  1 
ATOM 1321 C CD  . PRO A 1 250 ? 217.604 285.698 354.871 1.00 117.15 ? 250 PRO A CD  1 
ATOM 1322 N N   . THR A 1 251 ? 213.720 284.202 355.195 1.00 118.46 ? 251 THR A N   1 
ATOM 1323 C CA  . THR A 1 251 ? 212.357 284.403 354.718 1.00 119.08 ? 251 THR A CA  1 
ATOM 1324 C C   . THR A 1 251 ? 211.393 283.285 355.084 1.00 117.48 ? 251 THR A C   1 
ATOM 1325 O O   . THR A 1 251 ? 210.191 283.554 355.192 1.00 114.43 ? 251 THR A O   1 
ATOM 1326 C CB  . THR A 1 251 ? 212.345 284.572 353.192 1.00 118.14 ? 251 THR A CB  1 
ATOM 1327 O OG1 . THR A 1 251 ? 213.249 283.634 352.596 1.00 118.76 ? 251 THR A OG1 1 
ATOM 1328 C CG2 . THR A 1 251 ? 212.754 285.979 352.812 1.00 114.52 ? 251 THR A CG2 1 
ATOM 1329 N N   . LYS A 1 252 ? 211.862 282.054 355.280 1.00 115.23 ? 252 LYS A N   1 
ATOM 1330 C CA  . LYS A 1 252 ? 210.993 280.932 355.625 1.00 114.70 ? 252 LYS A CA  1 
ATOM 1331 C C   . LYS A 1 252 ? 209.976 280.678 354.511 1.00 113.46 ? 252 LYS A C   1 
ATOM 1332 O O   . LYS A 1 252 ? 208.772 280.559 354.743 1.00 115.59 ? 252 LYS A O   1 
ATOM 1333 C CB  . LYS A 1 252 ? 210.289 281.184 356.962 1.00 118.10 ? 252 LYS A CB  1 
ATOM 1334 C CG  . LYS A 1 252 ? 211.216 281.618 358.086 1.00 118.19 ? 252 LYS A CG  1 
ATOM 1335 C CD  . LYS A 1 252 ? 210.438 282.101 359.301 1.00 118.09 ? 252 LYS A CD  1 
ATOM 1336 C CE  . LYS A 1 252 ? 209.742 280.960 360.022 1.00 117.67 ? 252 LYS A CE  1 
ATOM 1337 N NZ  . LYS A 1 252 ? 210.712 279.989 360.597 1.00 116.60 ? 252 LYS A NZ  1 
ATOM 1338 N N   . VAL A 1 253 ? 210.487 280.594 353.286 1.00 96.97  ? 253 VAL A N   1 
ATOM 1339 C CA  . VAL A 1 253 ? 209.641 280.410 352.112 1.00 99.58  ? 253 VAL A CA  1 
ATOM 1340 C C   . VAL A 1 253 ? 209.148 278.972 352.065 1.00 96.71  ? 253 VAL A C   1 
ATOM 1341 O O   . VAL A 1 253 ? 209.879 278.070 351.639 1.00 94.69  ? 253 VAL A O   1 
ATOM 1342 C CB  . VAL A 1 253 ? 210.396 280.768 350.820 1.00 98.64  ? 253 VAL A CB  1 
ATOM 1343 C CG1 . VAL A 1 253 ? 209.472 280.662 349.619 1.00 95.31  ? 253 VAL A CG1 1 
ATOM 1344 C CG2 . VAL A 1 253 ? 210.989 282.157 350.920 1.00 99.02  ? 253 VAL A CG2 1 
ATOM 1345 N N   . THR A 1 254 ? 207.909 278.745 352.490 1.00 91.76  ? 254 THR A N   1 
ATOM 1346 C CA  . THR A 1 254 ? 207.362 277.397 352.454 1.00 90.23  ? 254 THR A CA  1 
ATOM 1347 C C   . THR A 1 254 ? 206.866 277.079 351.050 1.00 88.61  ? 254 THR A C   1 
ATOM 1348 O O   . THR A 1 254 ? 206.491 277.971 350.290 1.00 90.75  ? 254 THR A O   1 
ATOM 1349 C CB  . THR A 1 254 ? 206.223 277.252 353.460 1.00 88.82  ? 254 THR A CB  1 
ATOM 1350 O OG1 . THR A 1 254 ? 206.671 277.671 354.755 1.00 89.25  ? 254 THR A OG1 1 
ATOM 1351 C CG2 . THR A 1 254 ? 205.760 275.807 353.535 1.00 85.60  ? 254 THR A CG2 1 
ATOM 1352 N N   . SER A 1 255 ? 206.879 275.794 350.700 1.00 72.93  ? 255 SER A N   1 
ATOM 1353 C CA  . SER A 1 255 ? 206.503 275.365 349.363 1.00 70.42  ? 255 SER A CA  1 
ATOM 1354 C C   . SER A 1 255 ? 205.796 274.023 349.443 1.00 70.01  ? 255 SER A C   1 
ATOM 1355 O O   . SER A 1 255 ? 206.065 273.213 350.333 1.00 73.47  ? 255 SER A O   1 
ATOM 1356 C CB  . SER A 1 255 ? 207.725 275.255 348.448 1.00 70.06  ? 255 SER A CB  1 
ATOM 1357 O OG  . SER A 1 255 ? 208.514 276.428 348.513 1.00 79.40  ? 255 SER A OG  1 
ATOM 1358 N N   . LYS A 1 256 ? 204.900 273.789 348.485 1.00 67.97  ? 256 LYS A N   1 
ATOM 1359 C CA  . LYS A 1 256 ? 204.109 272.564 348.433 1.00 67.81  ? 256 LYS A CA  1 
ATOM 1360 C C   . LYS A 1 256 ? 204.040 272.100 346.987 1.00 64.53  ? 256 LYS A C   1 
ATOM 1361 O O   . LYS A 1 256 ? 203.320 272.690 346.178 1.00 63.98  ? 256 LYS A O   1 
ATOM 1362 C CB  . LYS A 1 256 ? 202.708 272.785 349.000 1.00 62.81  ? 256 LYS A CB  1 
ATOM 1363 C CG  . LYS A 1 256 ? 202.693 273.103 350.481 1.00 66.33  ? 256 LYS A CG  1 
ATOM 1364 C CD  . LYS A 1 256 ? 201.282 273.114 351.028 1.00 68.69  ? 256 LYS A CD  1 
ATOM 1365 C CE  . LYS A 1 256 ? 201.277 273.288 352.537 1.00 71.31  ? 256 LYS A CE  1 
ATOM 1366 N NZ  . LYS A 1 256 ? 201.911 274.564 352.965 1.00 72.63  ? 256 LYS A NZ  1 
ATOM 1367 N N   . ILE A 1 257 ? 204.782 271.048 346.668 1.00 57.82  ? 257 ILE A N   1 
ATOM 1368 C CA  . ILE A 1 257 ? 204.799 270.480 345.327 1.00 59.70  ? 257 ILE A CA  1 
ATOM 1369 C C   . ILE A 1 257 ? 203.664 269.473 345.220 1.00 56.41  ? 257 ILE A C   1 
ATOM 1370 O O   . ILE A 1 257 ? 203.640 268.475 345.945 1.00 64.61  ? 257 ILE A O   1 
ATOM 1371 C CB  . ILE A 1 257 ? 206.151 269.816 345.023 1.00 61.99  ? 257 ILE A CB  1 
ATOM 1372 C CG1 . ILE A 1 257 ? 207.277 270.850 345.043 1.00 64.98  ? 257 ILE A CG1 1 
ATOM 1373 C CG2 . ILE A 1 257 ? 206.111 269.109 343.679 1.00 59.53  ? 257 ILE A CG2 1 
ATOM 1374 C CD1 . ILE A 1 257 ? 207.751 271.214 346.428 1.00 65.47  ? 257 ILE A CD1 1 
ATOM 1375 N N   . ARG A 1 258 ? 202.722 269.732 344.321 1.00 50.21  ? 258 ARG A N   1 
ATOM 1376 C CA  . ARG A 1 258 ? 201.662 268.782 344.021 1.00 53.22  ? 258 ARG A CA  1 
ATOM 1377 C C   . ARG A 1 258 ? 202.131 267.863 342.904 1.00 49.09  ? 258 ARG A C   1 
ATOM 1378 O O   . ARG A 1 258 ? 202.648 268.334 341.886 1.00 51.22  ? 258 ARG A O   1 
ATOM 1379 C CB  . ARG A 1 258 ? 200.383 269.511 343.611 1.00 61.39  ? 258 ARG A CB  1 
ATOM 1380 C CG  . ARG A 1 258 ? 199.692 270.217 344.757 1.00 55.64  ? 258 ARG A CG  1 
ATOM 1381 C CD  . ARG A 1 258 ? 198.672 271.225 344.273 1.00 46.75  ? 258 ARG A CD  1 
ATOM 1382 N NE  . ARG A 1 258 ? 197.877 271.745 345.377 1.00 49.82  ? 258 ARG A NE  1 
ATOM 1383 C CZ  . ARG A 1 258 ? 198.333 272.579 346.302 1.00 56.49  ? 258 ARG A CZ  1 
ATOM 1384 N NH1 . ARG A 1 258 ? 199.582 273.011 346.287 1.00 57.25  ? 258 ARG A NH1 1 
ATOM 1385 N NH2 . ARG A 1 258 ? 197.515 272.989 347.266 1.00 60.13  ? 258 ARG A NH2 1 
ATOM 1386 N N   . VAL A 1 259 ? 201.964 266.556 343.094 1.00 41.90  ? 259 VAL A N   1 
ATOM 1387 C CA  . VAL A 1 259 ? 202.411 265.563 342.124 1.00 46.45  ? 259 VAL A CA  1 
ATOM 1388 C C   . VAL A 1 259 ? 201.190 264.981 341.430 1.00 51.32  ? 259 VAL A C   1 
ATOM 1389 O O   . VAL A 1 259 ? 200.265 264.498 342.093 1.00 62.22  ? 259 VAL A O   1 
ATOM 1390 C CB  . VAL A 1 259 ? 203.239 264.453 342.791 1.00 54.84  ? 259 VAL A CB  1 
ATOM 1391 C CG1 . VAL A 1 259 ? 203.934 263.609 341.737 1.00 51.10  ? 259 VAL A CG1 1 
ATOM 1392 C CG2 . VAL A 1 259 ? 204.247 265.044 343.759 1.00 51.96  ? 259 VAL A CG2 1 
ATOM 1393 N N   . TYR A 1 260 ? 201.191 265.023 340.100 1.00 50.94  ? 260 TYR A N   1 
ATOM 1394 C CA  . TYR A 1 260 ? 200.122 264.476 339.277 1.00 53.83  ? 260 TYR A CA  1 
ATOM 1395 C C   . TYR A 1 260 ? 200.663 263.291 338.493 1.00 50.52  ? 260 TYR A C   1 
ATOM 1396 O O   . TYR A 1 260 ? 201.679 263.412 337.804 1.00 55.05  ? 260 TYR A O   1 
ATOM 1397 C CB  . TYR A 1 260 ? 199.562 265.537 338.323 1.00 45.56  ? 260 TYR A CB  1 
ATOM 1398 C CG  . TYR A 1 260 ? 198.761 266.601 339.028 1.00 42.49  ? 260 TYR A CG  1 
ATOM 1399 C CD1 . TYR A 1 260 ? 199.377 267.717 339.567 1.00 44.99  ? 260 TYR A CD1 1 
ATOM 1400 C CD2 . TYR A 1 260 ? 197.389 266.480 339.169 1.00 51.03  ? 260 TYR A CD2 1 
ATOM 1401 C CE1 . TYR A 1 260 ? 198.649 268.684 340.222 1.00 48.92  ? 260 TYR A CE1 1 
ATOM 1402 C CE2 . TYR A 1 260 ? 196.653 267.442 339.821 1.00 54.39  ? 260 TYR A CE2 1 
ATOM 1403 C CZ  . TYR A 1 260 ? 197.287 268.541 340.346 1.00 55.95  ? 260 TYR A CZ  1 
ATOM 1404 O OH  . TYR A 1 260 ? 196.553 269.500 340.999 1.00 63.05  ? 260 TYR A OH  1 
ATOM 1405 N N   . LEU A 1 261 ? 199.987 262.155 338.601 1.00 45.08  ? 261 LEU A N   1 
ATOM 1406 C CA  . LEU A 1 261 ? 200.413 260.918 337.962 1.00 42.38  ? 261 LEU A CA  1 
ATOM 1407 C C   . LEU A 1 261 ? 199.395 260.546 336.895 1.00 53.94  ? 261 LEU A C   1 
ATOM 1408 O O   . LEU A 1 261 ? 198.209 260.383 337.198 1.00 67.72  ? 261 LEU A O   1 
ATOM 1409 C CB  . LEU A 1 261 ? 200.550 259.802 338.997 1.00 48.41  ? 261 LEU A CB  1 
ATOM 1410 C CG  . LEU A 1 261 ? 201.246 258.509 338.573 1.00 57.75  ? 261 LEU A CG  1 
ATOM 1411 C CD1 . LEU A 1 261 ? 201.600 257.693 339.798 1.00 51.41  ? 261 LEU A CD1 1 
ATOM 1412 C CD2 . LEU A 1 261 ? 200.381 257.693 337.636 1.00 53.57  ? 261 LEU A CD2 1 
ATOM 1413 N N   . LYS A 1 262 ? 199.856 260.409 335.655 1.00 44.50  ? 262 LYS A N   1 
ATOM 1414 C CA  . LYS A 1 262 ? 199.006 259.981 334.543 1.00 52.40  ? 262 LYS A CA  1 
ATOM 1415 C C   . LYS A 1 262 ? 199.550 258.686 333.964 1.00 47.09  ? 262 LYS A C   1 
ATOM 1416 O O   . LYS A 1 262 ? 200.467 258.718 333.125 1.00 48.08  ? 262 LYS A O   1 
ATOM 1417 C CB  . LYS A 1 262 ? 198.930 261.051 333.457 1.00 50.92  ? 262 LYS A CB  1 
ATOM 1418 C CG  . LYS A 1 262 ? 198.173 260.586 332.222 1.00 52.00  ? 262 LYS A CG  1 
ATOM 1419 C CD  . LYS A 1 262 ? 197.849 261.726 331.276 1.00 53.04  ? 262 LYS A CD  1 
ATOM 1420 C CE  . LYS A 1 262 ? 199.021 262.058 330.377 1.00 57.33  ? 262 LYS A CE  1 
ATOM 1421 N NZ  . LYS A 1 262 ? 198.678 263.110 329.381 1.00 58.82  ? 262 LYS A NZ  1 
ATOM 1422 N N   . PRO A 1 263 ? 199.025 257.525 334.356 1.00 44.26  ? 263 PRO A N   1 
ATOM 1423 C CA  . PRO A 1 263 ? 199.536 256.266 333.799 1.00 47.33  ? 263 PRO A CA  1 
ATOM 1424 C C   . PRO A 1 263 ? 199.206 256.163 332.318 1.00 51.84  ? 263 PRO A C   1 
ATOM 1425 O O   . PRO A 1 263 ? 198.038 256.200 331.930 1.00 59.63  ? 263 PRO A O   1 
ATOM 1426 C CB  . PRO A 1 263 ? 198.809 255.198 334.620 1.00 47.68  ? 263 PRO A CB  1 
ATOM 1427 C CG  . PRO A 1 263 ? 197.555 255.849 335.038 1.00 44.74  ? 263 PRO A CG  1 
ATOM 1428 C CD  . PRO A 1 263 ? 197.882 257.296 335.254 1.00 46.28  ? 263 PRO A CD  1 
ATOM 1429 N N   . LYS A 1 264 ? 200.238 256.027 331.492 1.00 47.89  ? 264 LYS A N   1 
ATOM 1430 C CA  . LYS A 1 264 ? 200.074 255.918 330.052 1.00 54.47  ? 264 LYS A CA  1 
ATOM 1431 C C   . LYS A 1 264 ? 200.611 254.578 329.567 1.00 55.66  ? 264 LYS A C   1 
ATOM 1432 O O   . LYS A 1 264 ? 201.367 253.899 330.264 1.00 63.06  ? 264 LYS A O   1 
ATOM 1433 C CB  . LYS A 1 264 ? 200.784 257.063 329.323 1.00 55.27  ? 264 LYS A CB  1 
ATOM 1434 C CG  . LYS A 1 264 ? 202.226 257.252 329.733 1.00 59.34  ? 264 LYS A CG  1 
ATOM 1435 C CD  . LYS A 1 264 ? 202.958 258.175 328.777 1.00 63.76  ? 264 LYS A CD  1 
ATOM 1436 C CE  . LYS A 1 264 ? 204.424 258.310 329.152 1.00 66.76  ? 264 LYS A CE  1 
ATOM 1437 N NZ  . LYS A 1 264 ? 205.201 259.055 328.123 1.00 65.22  ? 264 LYS A NZ  1 
ATOM 1438 N N   . HIS A 1 265 ? 200.208 254.203 328.352 1.00 57.81  ? 265 HIS A N   1 
ATOM 1439 C CA  . HIS A 1 265 ? 200.573 252.914 327.768 1.00 60.45  ? 265 HIS A CA  1 
ATOM 1440 C C   . HIS A 1 265 ? 200.208 251.771 328.712 1.00 58.79  ? 265 HIS A C   1 
ATOM 1441 O O   . HIS A 1 265 ? 201.005 250.868 328.971 1.00 54.30  ? 265 HIS A O   1 
ATOM 1442 C CB  . HIS A 1 265 ? 202.062 252.869 327.421 1.00 64.12  ? 265 HIS A CB  1 
ATOM 1443 C CG  . HIS A 1 265 ? 202.477 253.876 326.395 1.00 66.19  ? 265 HIS A CG  1 
ATOM 1444 N ND1 . HIS A 1 265 ? 202.777 255.182 326.714 1.00 66.38  ? 265 HIS A ND1 1 
ATOM 1445 C CD2 . HIS A 1 265 ? 202.650 253.765 325.058 1.00 65.33  ? 265 HIS A CD2 1 
ATOM 1446 C CE1 . HIS A 1 265 ? 203.115 255.834 325.616 1.00 64.33  ? 265 HIS A CE1 1 
ATOM 1447 N NE2 . HIS A 1 265 ? 203.045 254.997 324.597 1.00 67.00  ? 265 HIS A NE2 1 
ATOM 1448 N N   . ILE A 1 266 ? 198.982 251.813 329.224 1.00 46.38  ? 266 ILE A N   1 
ATOM 1449 C CA  . ILE A 1 266 ? 198.548 250.934 330.304 1.00 45.08  ? 266 ILE A CA  1 
ATOM 1450 C C   . ILE A 1 266 ? 197.805 249.740 329.723 1.00 41.42  ? 266 ILE A C   1 
ATOM 1451 O O   . ILE A 1 266 ? 196.907 249.900 328.888 1.00 33.14  ? 266 ILE A O   1 
ATOM 1452 C CB  . ILE A 1 266 ? 197.669 251.687 331.316 1.00 39.98  ? 266 ILE A CB  1 
ATOM 1453 C CG1 . ILE A 1 266 ? 197.084 250.708 332.329 1.00 42.67  ? 266 ILE A CG1 1 
ATOM 1454 C CG2 . ILE A 1 266 ? 196.559 252.444 330.616 1.00 46.07  ? 266 ILE A CG2 1 
ATOM 1455 C CD1 . ILE A 1 266 ? 196.585 251.369 333.582 1.00 51.81  ? 266 ILE A CD1 1 
ATOM 1456 N N   . ARG A 1 267 ? 198.187 248.542 330.161 1.00 49.38  ? 267 ARG A N   1 
ATOM 1457 C CA  . ARG A 1 267 ? 197.481 247.309 329.847 1.00 44.72  ? 267 ARG A CA  1 
ATOM 1458 C C   . ARG A 1 267 ? 197.052 246.654 331.150 1.00 41.43  ? 267 ARG A C   1 
ATOM 1459 O O   . ARG A 1 267 ? 197.725 246.793 332.172 1.00 44.03  ? 267 ARG A O   1 
ATOM 1460 C CB  . ARG A 1 267 ? 198.357 246.341 329.053 1.00 46.85  ? 267 ARG A CB  1 
ATOM 1461 C CG  . ARG A 1 267 ? 199.075 246.966 327.877 1.00 48.06  ? 267 ARG A CG  1 
ATOM 1462 C CD  . ARG A 1 267 ? 200.114 246.021 327.306 1.00 49.66  ? 267 ARG A CD  1 
ATOM 1463 N NE  . ARG A 1 267 ? 199.512 244.877 326.636 1.00 53.79  ? 267 ARG A NE  1 
ATOM 1464 C CZ  . ARG A 1 267 ? 200.195 243.843 326.164 1.00 55.53  ? 267 ARG A CZ  1 
ATOM 1465 N NH1 . ARG A 1 267 ? 201.508 243.763 326.295 1.00 51.35  ? 267 ARG A NH1 1 
ATOM 1466 N NH2 . ARG A 1 267 ? 199.543 242.863 325.545 1.00 54.84  ? 267 ARG A NH2 1 
ATOM 1467 N N   . VAL A 1 268 ? 195.931 245.940 331.119 1.00 32.17  ? 268 VAL A N   1 
ATOM 1468 C CA  . VAL A 1 268 ? 195.387 245.311 332.317 1.00 35.59  ? 268 VAL A CA  1 
ATOM 1469 C C   . VAL A 1 268 ? 194.836 243.941 331.959 1.00 42.51  ? 268 VAL A C   1 
ATOM 1470 O O   . VAL A 1 268 ? 194.250 243.755 330.888 1.00 46.07  ? 268 VAL A O   1 
ATOM 1471 C CB  . VAL A 1 268 ? 194.295 246.178 332.969 1.00 34.54  ? 268 VAL A CB  1 
ATOM 1472 C CG1 . VAL A 1 268 ? 194.902 247.436 333.555 1.00 39.04  ? 268 VAL A CG1 1 
ATOM 1473 C CG2 . VAL A 1 268 ? 193.220 246.517 331.958 1.00 43.51  ? 268 VAL A CG2 1 
ATOM 1474 N N   . TRP A 1 269 ? 195.015 242.986 332.870 1.00 41.72  ? 269 TRP A N   1 
ATOM 1475 C CA  . TRP A 1 269 ? 194.579 241.612 332.681 1.00 38.48  ? 269 TRP A CA  1 
ATOM 1476 C C   . TRP A 1 269 ? 193.723 241.173 333.861 1.00 37.74  ? 269 TRP A C   1 
ATOM 1477 O O   . TRP A 1 269 ? 193.737 241.787 334.931 1.00 27.04  ? 269 TRP A O   1 
ATOM 1478 C CB  . TRP A 1 269 ? 195.769 240.652 332.550 1.00 40.86  ? 269 TRP A CB  1 
ATOM 1479 C CG  . TRP A 1 269 ? 196.664 240.912 331.388 1.00 34.48  ? 269 TRP A CG  1 
ATOM 1480 C CD1 . TRP A 1 269 ? 196.556 240.383 330.141 1.00 41.69  ? 269 TRP A CD1 1 
ATOM 1481 C CD2 . TRP A 1 269 ? 197.821 241.749 331.370 1.00 34.44  ? 269 TRP A CD2 1 
ATOM 1482 N NE1 . TRP A 1 269 ? 197.571 240.842 329.341 1.00 33.61  ? 269 TRP A NE1 1 
ATOM 1483 C CE2 . TRP A 1 269 ? 198.362 241.684 330.074 1.00 39.43  ? 269 TRP A CE2 1 
ATOM 1484 C CE3 . TRP A 1 269 ? 198.451 242.551 332.322 1.00 38.82  ? 269 TRP A CE3 1 
ATOM 1485 C CZ2 . TRP A 1 269 ? 199.499 242.391 329.706 1.00 42.23  ? 269 TRP A CZ2 1 
ATOM 1486 C CZ3 . TRP A 1 269 ? 199.577 243.251 331.955 1.00 43.79  ? 269 TRP A CZ3 1 
ATOM 1487 C CH2 . TRP A 1 269 ? 200.091 243.167 330.659 1.00 41.92  ? 269 TRP A CH2 1 
ATOM 1488 N N   . CYS A 1 270 ? 192.973 240.093 333.650 1.00 41.31  ? 270 CYS A N   1 
ATOM 1489 C CA  . CYS A 1 270 ? 192.299 239.386 334.730 1.00 42.30  ? 270 CYS A CA  1 
ATOM 1490 C C   . CYS A 1 270 ? 191.348 240.287 335.507 1.00 38.71  ? 270 CYS A C   1 
ATOM 1491 O O   . CYS A 1 270 ? 191.640 240.652 336.651 1.00 44.05  ? 270 CYS A O   1 
ATOM 1492 C CB  . CYS A 1 270 ? 193.331 238.783 335.678 1.00 43.05  ? 270 CYS A CB  1 
ATOM 1493 S SG  . CYS A 1 270 ? 194.435 237.601 334.885 1.00 61.26  ? 270 CYS A SG  1 
ATOM 1494 N N   . PRO A 1 271 ? 190.207 240.659 334.931 1.00 27.86  ? 271 PRO A N   1 
ATOM 1495 C CA  . PRO A 1 271 ? 189.273 241.531 335.648 1.00 34.65  ? 271 PRO A CA  1 
ATOM 1496 C C   . PRO A 1 271 ? 188.782 240.898 336.940 1.00 28.82  ? 271 PRO A C   1 
ATOM 1497 O O   . PRO A 1 271 ? 188.691 239.677 337.063 1.00 39.45  ? 271 PRO A O   1 
ATOM 1498 C CB  . PRO A 1 271 ? 188.128 241.724 334.650 1.00 33.70  ? 271 PRO A CB  1 
ATOM 1499 C CG  . PRO A 1 271 ? 188.256 240.607 333.688 1.00 34.55  ? 271 PRO A CG  1 
ATOM 1500 C CD  . PRO A 1 271 ? 189.707 240.297 333.598 1.00 29.69  ? 271 PRO A CD  1 
ATOM 1501 N N   . ARG A 1 272 ? 188.474 241.749 337.908 1.00 29.48  ? 272 ARG A N   1 
ATOM 1502 C CA  . ARG A 1 272 ? 188.017 241.350 339.228 1.00 39.73  ? 272 ARG A CA  1 
ATOM 1503 C C   . ARG A 1 272 ? 186.805 242.174 339.626 1.00 42.38  ? 272 ARG A C   1 
ATOM 1504 O O   . ARG A 1 272 ? 186.539 243.226 339.037 1.00 56.79  ? 272 ARG A O   1 
ATOM 1505 C CB  . ARG A 1 272 ? 189.120 241.533 340.278 1.00 33.12  ? 272 ARG A CB  1 
ATOM 1506 C CG  . ARG A 1 272 ? 190.411 240.815 339.959 1.00 39.67  ? 272 ARG A CG  1 
ATOM 1507 C CD  . ARG A 1 272 ? 191.473 241.138 340.989 1.00 43.82  ? 272 ARG A CD  1 
ATOM 1508 N NE  . ARG A 1 272 ? 191.145 240.604 342.304 1.00 46.95  ? 272 ARG A NE  1 
ATOM 1509 C CZ  . ARG A 1 272 ? 191.456 239.383 342.717 1.00 41.76  ? 272 ARG A CZ  1 
ATOM 1510 N NH1 . ARG A 1 272 ? 192.094 238.529 341.934 1.00 39.74  ? 272 ARG A NH1 1 
ATOM 1511 N NH2 . ARG A 1 272 ? 191.117 239.008 343.946 1.00 43.03  ? 272 ARG A NH2 1 
ATOM 1512 N N   . PRO A 1 273 ? 186.044 241.720 340.616 1.00 40.11  ? 273 PRO A N   1 
ATOM 1513 C CA  . PRO A 1 273 ? 184.945 242.528 341.133 1.00 38.36  ? 273 PRO A CA  1 
ATOM 1514 C C   . PRO A 1 273 ? 185.449 243.862 341.649 1.00 52.90  ? 273 PRO A C   1 
ATOM 1515 O O   . PRO A 1 273 ? 186.539 243.935 342.234 1.00 63.74  ? 273 PRO A O   1 
ATOM 1516 C CB  . PRO A 1 273 ? 184.388 241.671 342.277 1.00 38.21  ? 273 PRO A CB  1 
ATOM 1517 C CG  . PRO A 1 273 ? 184.756 240.299 341.931 1.00 49.91  ? 273 PRO A CG  1 
ATOM 1518 C CD  . PRO A 1 273 ? 186.077 240.388 341.237 1.00 48.96  ? 273 PRO A CD  1 
ATOM 1519 N N   . PRO A 1 274 ? 184.693 244.938 341.457 1.00 48.33  ? 274 PRO A N   1 
ATOM 1520 C CA  . PRO A 1 274 ? 185.093 246.226 342.030 1.00 47.42  ? 274 PRO A CA  1 
ATOM 1521 C C   . PRO A 1 274 ? 184.823 246.293 343.523 1.00 47.16  ? 274 PRO A C   1 
ATOM 1522 O O   . PRO A 1 274 ? 183.754 245.910 344.003 1.00 50.86  ? 274 PRO A O   1 
ATOM 1523 C CB  . PRO A 1 274 ? 184.226 247.230 341.266 1.00 48.79  ? 274 PRO A CB  1 
ATOM 1524 C CG  . PRO A 1 274 ? 183.024 246.462 340.889 1.00 54.49  ? 274 PRO A CG  1 
ATOM 1525 C CD  . PRO A 1 274 ? 183.505 245.072 340.599 1.00 50.53  ? 274 PRO A CD  1 
ATOM 1526 N N   . ARG A 1 275 ? 185.812 246.788 344.255 1.00 58.28  ? 275 ARG A N   1 
ATOM 1527 C CA  . ARG A 1 275 ? 185.680 246.986 345.687 1.00 59.39  ? 275 ARG A CA  1 
ATOM 1528 C C   . ARG A 1 275 ? 184.724 248.138 345.975 1.00 68.83  ? 275 ARG A C   1 
ATOM 1529 O O   . ARG A 1 275 ? 184.633 249.108 345.220 1.00 72.97  ? 275 ARG A O   1 
ATOM 1530 C CB  . ARG A 1 275 ? 187.044 247.278 346.306 1.00 64.48  ? 275 ARG A CB  1 
ATOM 1531 C CG  . ARG A 1 275 ? 187.117 247.075 347.807 1.00 67.25  ? 275 ARG A CG  1 
ATOM 1532 C CD  . ARG A 1 275 ? 187.005 245.613 348.203 1.00 71.12  ? 275 ARG A CD  1 
ATOM 1533 N NE  . ARG A 1 275 ? 187.748 244.737 347.305 1.00 74.92  ? 275 ARG A NE  1 
ATOM 1534 C CZ  . ARG A 1 275 ? 189.059 244.545 347.355 1.00 71.63  ? 275 ARG A CZ  1 
ATOM 1535 N NH1 . ARG A 1 275 ? 189.814 245.154 348.254 1.00 69.22  ? 275 ARG A NH1 1 
ATOM 1536 N NH2 . ARG A 1 275 ? 189.627 243.725 346.477 1.00 72.12  ? 275 ARG A NH2 1 
ATOM 1537 N N   . ALA A 1 276 ? 184.007 248.027 347.089 1.00 71.52  ? 276 ALA A N   1 
ATOM 1538 C CA  . ALA A 1 276 ? 183.110 249.097 347.488 1.00 74.55  ? 276 ALA A CA  1 
ATOM 1539 C C   . ALA A 1 276 ? 183.901 250.383 347.726 1.00 73.62  ? 276 ALA A C   1 
ATOM 1540 O O   . ALA A 1 276 ? 185.117 250.373 347.919 1.00 72.93  ? 276 ALA A O   1 
ATOM 1541 C CB  . ALA A 1 276 ? 182.335 248.703 348.744 1.00 71.28  ? 276 ALA A CB  1 
ATOM 1542 N N   . VAL A 1 277 ? 183.188 251.512 347.708 1.00 76.17  ? 277 VAL A N   1 
ATOM 1543 C CA  . VAL A 1 277 ? 183.817 252.818 347.872 1.00 79.44  ? 277 VAL A CA  1 
ATOM 1544 C C   . VAL A 1 277 ? 184.110 253.141 349.328 1.00 79.11  ? 277 VAL A C   1 
ATOM 1545 O O   . VAL A 1 277 ? 184.849 254.094 349.606 1.00 78.88  ? 277 VAL A O   1 
ATOM 1546 C CB  . VAL A 1 277 ? 182.950 253.933 347.254 1.00 80.13  ? 277 VAL A CB  1 
ATOM 1547 C CG1 . VAL A 1 277 ? 183.679 255.271 347.315 1.00 73.69  ? 277 VAL A CG1 1 
ATOM 1548 C CG2 . VAL A 1 277 ? 182.572 253.589 345.820 1.00 76.21  ? 277 VAL A CG2 1 
ATOM 1549 N N   . ALA A 1 278 ? 183.550 252.382 350.268 1.00 75.51  ? 278 ALA A N   1 
ATOM 1550 C CA  . ALA A 1 278 ? 183.877 252.557 351.676 1.00 74.34  ? 278 ALA A CA  1 
ATOM 1551 C C   . ALA A 1 278 ? 185.146 251.817 352.071 1.00 74.79  ? 278 ALA A C   1 
ATOM 1552 O O   . ALA A 1 278 ? 185.829 252.231 353.014 1.00 72.42  ? 278 ALA A O   1 
ATOM 1553 C CB  . ALA A 1 278 ? 182.714 252.082 352.550 1.00 70.20  ? 278 ALA A CB  1 
ATOM 1554 N N   . TYR A 1 279 ? 185.477 250.730 351.369 1.00 78.42  ? 279 TYR A N   1 
ATOM 1555 C CA  . TYR A 1 279 ? 186.717 250.017 351.651 1.00 78.57  ? 279 TYR A CA  1 
ATOM 1556 C C   . TYR A 1 279 ? 187.935 250.822 351.219 1.00 79.33  ? 279 TYR A C   1 
ATOM 1557 O O   . TYR A 1 279 ? 189.029 250.616 351.754 1.00 77.79  ? 279 TYR A O   1 
ATOM 1558 C CB  . TYR A 1 279 ? 186.710 248.660 350.948 1.00 75.44  ? 279 TYR A CB  1 
ATOM 1559 C CG  . TYR A 1 279 ? 187.959 247.833 351.171 1.00 75.12  ? 279 TYR A CG  1 
ATOM 1560 C CD1 . TYR A 1 279 ? 189.107 248.052 350.422 1.00 74.75  ? 279 TYR A CD1 1 
ATOM 1561 C CD2 . TYR A 1 279 ? 187.987 246.826 352.125 1.00 78.90  ? 279 TYR A CD2 1 
ATOM 1562 C CE1 . TYR A 1 279 ? 190.246 247.301 350.621 1.00 77.80  ? 279 TYR A CE1 1 
ATOM 1563 C CE2 . TYR A 1 279 ? 189.123 246.067 352.331 1.00 79.54  ? 279 TYR A CE2 1 
ATOM 1564 C CZ  . TYR A 1 279 ? 190.249 246.309 351.575 1.00 81.75  ? 279 TYR A CZ  1 
ATOM 1565 O OH  . TYR A 1 279 ? 191.384 245.557 351.775 1.00 78.36  ? 279 TYR A OH  1 
ATOM 1566 N N   . TYR A 1 280 ? 187.763 251.733 350.263 1.00 68.68  ? 280 TYR A N   1 
ATOM 1567 C CA  . TYR A 1 280 ? 188.860 252.494 349.668 1.00 61.89  ? 280 TYR A CA  1 
ATOM 1568 C C   . TYR A 1 280 ? 189.617 251.623 348.670 1.00 59.99  ? 280 TYR A C   1 
ATOM 1569 O O   . TYR A 1 280 ? 189.085 251.253 347.624 1.00 51.29  ? 280 TYR A O   1 
ATOM 1570 C CB  . TYR A 1 280 ? 189.824 253.023 350.733 1.00 70.05  ? 280 TYR A CB  1 
ATOM 1571 C CG  . TYR A 1 280 ? 189.154 253.626 351.949 1.00 70.13  ? 280 TYR A CG  1 
ATOM 1572 C CD1 . TYR A 1 280 ? 187.933 254.274 351.848 1.00 69.23  ? 280 TYR A CD1 1 
ATOM 1573 C CD2 . TYR A 1 280 ? 189.750 253.547 353.200 1.00 68.39  ? 280 TYR A CD2 1 
ATOM 1574 C CE1 . TYR A 1 280 ? 187.324 254.825 352.957 1.00 71.69  ? 280 TYR A CE1 1 
ATOM 1575 C CE2 . TYR A 1 280 ? 189.148 254.094 354.314 1.00 66.42  ? 280 TYR A CE2 1 
ATOM 1576 C CZ  . TYR A 1 280 ? 187.936 254.732 354.187 1.00 70.83  ? 280 TYR A CZ  1 
ATOM 1577 O OH  . TYR A 1 280 ? 187.333 255.279 355.296 1.00 69.73  ? 280 TYR A OH  1 
ATOM 1578 N N   . GLN B 2 84  ? 184.251 207.702 330.750 1.00 90.91  ? 84  GLN B N   1 
ATOM 1579 C CA  . GLN B 2 84  ? 185.482 207.171 331.323 1.00 92.01  ? 84  GLN B CA  1 
ATOM 1580 C C   . GLN B 2 84  ? 186.694 207.845 330.688 1.00 90.86  ? 84  GLN B C   1 
ATOM 1581 O O   . GLN B 2 84  ? 186.870 207.799 329.471 1.00 91.87  ? 84  GLN B O   1 
ATOM 1582 C CB  . GLN B 2 84  ? 185.555 205.656 331.125 1.00 92.43  ? 84  GLN B CB  1 
ATOM 1583 C CG  . GLN B 2 84  ? 186.530 204.952 332.056 1.00 92.74  ? 84  GLN B CG  1 
ATOM 1584 C CD  . GLN B 2 84  ? 186.030 204.872 333.487 1.00 92.83  ? 84  GLN B CD  1 
ATOM 1585 O OE1 . GLN B 2 84  ? 186.752 205.201 334.427 1.00 91.86  ? 84  GLN B OE1 1 
ATOM 1586 N NE2 . GLN B 2 84  ? 184.793 204.423 333.659 1.00 93.75  ? 84  GLN B NE2 1 
ATOM 1587 N N   . LEU B 2 85  ? 187.522 208.477 331.515 1.00 88.35  ? 85  LEU B N   1 
ATOM 1588 C CA  . LEU B 2 85  ? 188.708 209.153 331.015 1.00 93.90  ? 85  LEU B CA  1 
ATOM 1589 C C   . LEU B 2 85  ? 189.880 208.180 330.914 1.00 98.28  ? 85  LEU B C   1 
ATOM 1590 O O   . LEU B 2 85  ? 189.798 207.019 331.325 1.00 96.57  ? 85  LEU B O   1 
ATOM 1591 C CB  . LEU B 2 85  ? 189.068 210.334 331.913 1.00 94.27  ? 85  LEU B CB  1 
ATOM 1592 C CG  . LEU B 2 85  ? 189.418 210.015 333.365 1.00 94.89  ? 85  LEU B CG  1 
ATOM 1593 C CD1 . LEU B 2 85  ? 190.893 209.721 333.526 1.00 92.83  ? 85  LEU B CD1 1 
ATOM 1594 C CD2 . LEU B 2 85  ? 189.012 211.172 334.243 1.00 93.82  ? 85  LEU B CD2 1 
ATOM 1595 N N   . THR B 2 86  ? 190.990 208.673 330.358 1.00 104.94 ? 86  THR B N   1 
ATOM 1596 C CA  . THR B 2 86  ? 192.113 207.825 329.974 1.00 103.87 ? 86  THR B CA  1 
ATOM 1597 C C   . THR B 2 86  ? 193.434 208.276 330.589 1.00 102.34 ? 86  THR B C   1 
ATOM 1598 O O   . THR B 2 86  ? 194.497 207.813 330.165 1.00 102.15 ? 86  THR B O   1 
ATOM 1599 C CB  . THR B 2 86  ? 192.240 207.787 328.450 1.00 105.50 ? 86  THR B CB  1 
ATOM 1600 O OG1 . THR B 2 86  ? 192.712 209.055 327.976 1.00 102.29 ? 86  THR B OG1 1 
ATOM 1601 C CG2 . THR B 2 86  ? 190.893 207.484 327.809 1.00 100.59 ? 86  THR B CG2 1 
ATOM 1602 N N   . LEU B 2 87  ? 193.400 209.169 331.577 1.00 89.82  ? 87  LEU B N   1 
ATOM 1603 C CA  . LEU B 2 87  ? 194.624 209.712 332.167 1.00 90.74  ? 87  LEU B CA  1 
ATOM 1604 C C   . LEU B 2 87  ? 195.210 208.705 333.153 1.00 89.94  ? 87  LEU B C   1 
ATOM 1605 O O   . LEU B 2 87  ? 194.886 208.677 334.343 1.00 87.25  ? 87  LEU B O   1 
ATOM 1606 C CB  . LEU B 2 87  ? 194.356 211.051 332.840 1.00 84.98  ? 87  LEU B CB  1 
ATOM 1607 C CG  . LEU B 2 87  ? 194.606 212.281 331.964 1.00 84.39  ? 87  LEU B CG  1 
ATOM 1608 C CD1 . LEU B 2 87  ? 193.556 212.413 330.864 1.00 83.78  ? 87  LEU B CD1 1 
ATOM 1609 C CD2 . LEU B 2 87  ? 194.678 213.545 332.813 1.00 82.61  ? 87  LEU B CD2 1 
ATOM 1610 N N   . GLY B 2 88  ? 196.094 207.862 332.631 1.00 93.84  ? 88  GLY B N   1 
ATOM 1611 C CA  . GLY B 2 88  ? 196.946 207.054 333.489 1.00 93.16  ? 88  GLY B CA  1 
ATOM 1612 C C   . GLY B 2 88  ? 196.167 206.134 334.405 1.00 90.58  ? 88  GLY B C   1 
ATOM 1613 O O   . GLY B 2 88  ? 195.179 205.506 334.012 1.00 92.38  ? 88  GLY B O   1 
ATOM 1614 N N   . ASN B 2 89  ? 196.632 206.046 335.652 1.00 86.05  ? 89  ASN B N   1 
ATOM 1615 C CA  . ASN B 2 89  ? 196.068 205.086 336.593 1.00 87.01  ? 89  ASN B CA  1 
ATOM 1616 C C   . ASN B 2 89  ? 194.619 205.413 336.929 1.00 92.42  ? 89  ASN B C   1 
ATOM 1617 O O   . ASN B 2 89  ? 193.772 204.514 336.994 1.00 87.73  ? 89  ASN B O   1 
ATOM 1618 C CB  . ASN B 2 89  ? 196.912 205.056 337.866 1.00 85.97  ? 89  ASN B CB  1 
ATOM 1619 C CG  . ASN B 2 89  ? 198.389 204.879 337.586 1.00 88.81  ? 89  ASN B CG  1 
ATOM 1620 O OD1 . ASN B 2 89  ? 198.780 204.109 336.710 1.00 90.75  ? 89  ASN B OD1 1 
ATOM 1621 N ND2 . ASN B 2 89  ? 199.220 205.594 338.333 1.00 85.88  ? 89  ASN B ND2 1 
ATOM 1622 N N   . SER B 2 90  ? 194.314 206.688 337.147 1.00 93.49  ? 90  SER B N   1 
ATOM 1623 C CA  . SER B 2 90  ? 193.013 207.108 337.646 1.00 87.80  ? 90  SER B CA  1 
ATOM 1624 C C   . SER B 2 90  ? 192.057 207.388 336.496 1.00 88.45  ? 90  SER B C   1 
ATOM 1625 O O   . SER B 2 90  ? 192.442 207.975 335.481 1.00 83.95  ? 90  SER B O   1 
ATOM 1626 C CB  . SER B 2 90  ? 193.144 208.357 338.518 1.00 85.22  ? 90  SER B CB  1 
ATOM 1627 O OG  . SER B 2 90  ? 193.865 208.077 339.705 1.00 89.41  ? 90  SER B OG  1 
ATOM 1628 N N   . THR B 2 91  ? 190.807 206.960 336.665 1.00 94.32  ? 91  THR B N   1 
ATOM 1629 C CA  . THR B 2 91  ? 189.752 207.196 335.688 1.00 89.75  ? 91  THR B CA  1 
ATOM 1630 C C   . THR B 2 91  ? 188.455 207.482 336.428 1.00 86.80  ? 91  THR B C   1 
ATOM 1631 O O   . THR B 2 91  ? 188.038 206.690 337.280 1.00 87.08  ? 91  THR B O   1 
ATOM 1632 C CB  . THR B 2 91  ? 189.578 205.995 334.755 1.00 89.82  ? 91  THR B CB  1 
ATOM 1633 O OG1 . THR B 2 91  ? 189.113 204.866 335.502 1.00 86.38  ? 91  THR B OG1 1 
ATOM 1634 C CG2 . THR B 2 91  ? 190.894 205.648 334.076 1.00 87.88  ? 91  THR B CG2 1 
ATOM 1635 N N   . ILE B 2 92  ? 187.822 208.607 336.106 1.00 83.92  ? 92  ILE B N   1 
ATOM 1636 C CA  . ILE B 2 92  ? 186.527 208.974 336.668 1.00 87.80  ? 92  ILE B CA  1 
ATOM 1637 C C   . ILE B 2 92  ? 185.478 208.846 335.574 1.00 92.34  ? 92  ILE B C   1 
ATOM 1638 O O   . ILE B 2 92  ? 185.733 209.188 334.412 1.00 92.62  ? 92  ILE B O   1 
ATOM 1639 C CB  . ILE B 2 92  ? 186.550 210.395 337.263 1.00 89.12  ? 92  ILE B CB  1 
ATOM 1640 C CG1 . ILE B 2 92  ? 186.002 211.431 336.269 1.00 83.34  ? 92  ILE B CG1 1 
ATOM 1641 C CG2 . ILE B 2 92  ? 187.959 210.752 337.725 1.00 87.37  ? 92  ILE B CG2 1 
ATOM 1642 C CD1 . ILE B 2 92  ? 186.396 212.858 336.579 1.00 79.34  ? 92  ILE B CD1 1 
ATOM 1643 N N   . THR B 2 93  ? 184.305 208.337 335.938 1.00 95.25  ? 93  THR B N   1 
ATOM 1644 C CA  . THR B 2 93  ? 183.217 208.149 334.983 1.00 92.69  ? 93  THR B CA  1 
ATOM 1645 C C   . THR B 2 93  ? 182.422 209.446 334.910 1.00 89.05  ? 93  THR B C   1 
ATOM 1646 O O   . THR B 2 93  ? 181.644 209.764 335.812 1.00 90.30  ? 93  THR B O   1 
ATOM 1647 C CB  . THR B 2 93  ? 182.332 206.980 335.401 1.00 93.09  ? 93  THR B CB  1 
ATOM 1648 O OG1 . THR B 2 93  ? 183.151 205.888 335.840 1.00 88.36  ? 93  THR B OG1 1 
ATOM 1649 C CG2 . THR B 2 93  ? 181.474 206.523 334.234 1.00 90.35  ? 93  THR B CG2 1 
ATOM 1650 N N   . ALA B 2 94  ? 182.619 210.203 333.834 1.00 84.38  ? 94  ALA B N   1 
ATOM 1651 C CA  . ALA B 2 94  ? 181.935 211.473 333.637 1.00 88.17  ? 94  ALA B CA  1 
ATOM 1652 C C   . ALA B 2 94  ? 181.102 211.401 332.368 1.00 92.88  ? 94  ALA B C   1 
ATOM 1653 O O   . ALA B 2 94  ? 181.616 211.051 331.300 1.00 89.94  ? 94  ALA B O   1 
ATOM 1654 C CB  . ALA B 2 94  ? 182.930 212.633 333.551 1.00 87.22  ? 94  ALA B CB  1 
ATOM 1655 N N   . GLN B 2 95  ? 179.821 211.732 332.489 1.00 97.31  ? 95  GLN B N   1 
ATOM 1656 C CA  . GLN B 2 95  ? 178.915 211.738 331.349 1.00 92.21  ? 95  GLN B CA  1 
ATOM 1657 C C   . GLN B 2 95  ? 179.248 212.892 330.411 1.00 90.68  ? 95  GLN B C   1 
ATOM 1658 O O   . GLN B 2 95  ? 180.058 213.758 330.741 1.00 87.49  ? 95  GLN B O   1 
ATOM 1659 C CB  . GLN B 2 95  ? 177.464 211.840 331.823 1.00 91.35  ? 95  GLN B CB  1 
ATOM 1660 C CG  . GLN B 2 95  ? 177.161 213.095 332.627 1.00 92.31  ? 95  GLN B CG  1 
ATOM 1661 C CD  . GLN B 2 95  ? 175.806 213.042 333.305 1.00 91.46  ? 95  GLN B CD  1 
ATOM 1662 O OE1 . GLN B 2 95  ? 175.090 212.046 333.210 1.00 91.90  ? 95  GLN B OE1 1 
ATOM 1663 N NE2 . GLN B 2 95  ? 175.447 214.118 333.996 1.00 87.48  ? 95  GLN B NE2 1 
ATOM 1664 N N   . ALA B 2 98  ? 176.538 222.110 330.700 1.00 72.50  ? 98  ALA B N   1 
ATOM 1665 C CA  . ALA B 2 98  ? 177.464 221.471 331.627 1.00 78.23  ? 98  ALA B CA  1 
ATOM 1666 C C   . ALA B 2 98  ? 178.793 221.162 330.948 1.00 79.03  ? 98  ALA B C   1 
ATOM 1667 O O   . ALA B 2 98  ? 179.653 220.499 331.526 1.00 71.40  ? 98  ALA B O   1 
ATOM 1668 C CB  . ALA B 2 98  ? 176.854 220.201 332.187 1.00 75.22  ? 98  ALA B CB  1 
ATOM 1669 N N   . ASN B 2 99  ? 178.956 221.642 329.719 1.00 86.61  ? 99  ASN B N   1 
ATOM 1670 C CA  . ASN B 2 99  ? 180.183 221.397 328.981 1.00 87.67  ? 99  ASN B CA  1 
ATOM 1671 C C   . ASN B 2 99  ? 181.328 222.214 329.581 1.00 86.91  ? 99  ASN B C   1 
ATOM 1672 O O   . ASN B 2 99  ? 181.131 223.095 330.423 1.00 81.06  ? 99  ASN B O   1 
ATOM 1673 C CB  . ASN B 2 99  ? 179.988 221.735 327.503 1.00 84.88  ? 99  ASN B CB  1 
ATOM 1674 C CG  . ASN B 2 99  ? 180.855 220.889 326.592 1.00 85.55  ? 99  ASN B CG  1 
ATOM 1675 O OD1 . ASN B 2 99  ? 181.978 220.528 326.942 1.00 85.97  ? 99  ASN B OD1 1 
ATOM 1676 N ND2 . ASN B 2 99  ? 180.333 220.562 325.417 1.00 82.20  ? 99  ASN B ND2 1 
ATOM 1677 N N   . SER B 2 100 ? 182.544 221.907 329.137 1.00 76.26  ? 100 SER B N   1 
ATOM 1678 C CA  . SER B 2 100 ? 183.726 222.543 329.700 1.00 72.47  ? 100 SER B CA  1 
ATOM 1679 C C   . SER B 2 100 ? 183.684 224.051 329.488 1.00 71.54  ? 100 SER B C   1 
ATOM 1680 O O   . SER B 2 100 ? 183.237 224.538 328.446 1.00 74.70  ? 100 SER B O   1 
ATOM 1681 C CB  . SER B 2 100 ? 184.988 221.962 329.066 1.00 70.30  ? 100 SER B CB  1 
ATOM 1682 O OG  . SER B 2 100 ? 185.025 222.229 327.675 1.00 74.78  ? 100 SER B OG  1 
ATOM 1683 N N   . VAL B 2 101 ? 184.157 224.788 330.486 1.00 55.54  ? 101 VAL B N   1 
ATOM 1684 C CA  . VAL B 2 101 ? 184.221 226.248 330.440 1.00 58.84  ? 101 VAL B CA  1 
ATOM 1685 C C   . VAL B 2 101 ? 185.695 226.620 330.529 1.00 56.92  ? 101 VAL B C   1 
ATOM 1686 O O   . VAL B 2 101 ? 186.246 226.797 331.619 1.00 60.01  ? 101 VAL B O   1 
ATOM 1687 C CB  . VAL B 2 101 ? 183.412 226.902 331.561 1.00 58.18  ? 101 VAL B CB  1 
ATOM 1688 C CG1 . VAL B 2 101 ? 183.740 228.380 331.657 1.00 52.24  ? 101 VAL B CG1 1 
ATOM 1689 C CG2 . VAL B 2 101 ? 181.928 226.699 331.326 1.00 64.51  ? 101 VAL B CG2 1 
ATOM 1690 N N   . VAL B 2 102 ? 186.346 226.756 329.377 1.00 51.13  ? 102 VAL B N   1 
ATOM 1691 C CA  . VAL B 2 102 ? 187.769 227.081 329.346 1.00 51.04  ? 102 VAL B CA  1 
ATOM 1692 C C   . VAL B 2 102 ? 187.935 228.525 329.809 1.00 55.33  ? 102 VAL B C   1 
ATOM 1693 O O   . VAL B 2 102 ? 187.499 229.460 329.133 1.00 65.46  ? 102 VAL B O   1 
ATOM 1694 C CB  . VAL B 2 102 ? 188.369 226.863 327.953 1.00 51.51  ? 102 VAL B CB  1 
ATOM 1695 C CG1 . VAL B 2 102 ? 187.700 227.757 326.924 1.00 53.33  ? 102 VAL B CG1 1 
ATOM 1696 C CG2 . VAL B 2 102 ? 189.864 227.111 327.982 1.00 53.21  ? 102 VAL B CG2 1 
ATOM 1697 N N   . ALA B 2 103 ? 188.562 228.709 330.967 1.00 45.26  ? 103 ALA B N   1 
ATOM 1698 C CA  . ALA B 2 103 ? 188.666 230.034 331.560 1.00 43.46  ? 103 ALA B CA  1 
ATOM 1699 C C   . ALA B 2 103 ? 189.400 230.985 330.626 1.00 49.77  ? 103 ALA B C   1 
ATOM 1700 O O   . ALA B 2 103 ? 190.450 230.648 330.074 1.00 48.83  ? 103 ALA B O   1 
ATOM 1701 C CB  . ALA B 2 103 ? 189.385 229.951 332.902 1.00 45.03  ? 103 ALA B CB  1 
ATOM 1702 N N   . TYR B 2 104 ? 188.838 232.176 330.445 1.00 52.28  ? 104 TYR B N   1 
ATOM 1703 C CA  . TYR B 2 104 ? 189.427 233.248 329.649 1.00 47.33  ? 104 TYR B CA  1 
ATOM 1704 C C   . TYR B 2 104 ? 189.641 232.855 328.196 1.00 48.29  ? 104 TYR B C   1 
ATOM 1705 O O   . TYR B 2 104 ? 190.337 233.567 327.465 1.00 48.06  ? 104 TYR B O   1 
ATOM 1706 C CB  . TYR B 2 104 ? 190.753 233.721 330.255 1.00 48.52  ? 104 TYR B CB  1 
ATOM 1707 C CG  . TYR B 2 104 ? 190.607 234.359 331.616 1.00 48.62  ? 104 TYR B CG  1 
ATOM 1708 C CD1 . TYR B 2 104 ? 189.616 235.294 331.864 1.00 46.19  ? 104 TYR B CD1 1 
ATOM 1709 C CD2 . TYR B 2 104 ? 191.457 234.021 332.655 1.00 48.48  ? 104 TYR B CD2 1 
ATOM 1710 C CE1 . TYR B 2 104 ? 189.480 235.877 333.104 1.00 48.66  ? 104 TYR B CE1 1 
ATOM 1711 C CE2 . TYR B 2 104 ? 191.327 234.599 333.899 1.00 46.85  ? 104 TYR B CE2 1 
ATOM 1712 C CZ  . TYR B 2 104 ? 190.337 235.524 334.117 1.00 44.67  ? 104 TYR B CZ  1 
ATOM 1713 O OH  . TYR B 2 104 ? 190.206 236.101 335.356 1.00 40.29  ? 104 TYR B OH  1 
ATOM 1714 N N   . GLY B 2 105 ? 189.061 231.745 327.751 1.00 55.87  ? 105 GLY B N   1 
ATOM 1715 C CA  . GLY B 2 105 ? 189.215 231.339 326.370 1.00 57.73  ? 105 GLY B CA  1 
ATOM 1716 C C   . GLY B 2 105 ? 190.607 230.891 325.998 1.00 55.48  ? 105 GLY B C   1 
ATOM 1717 O O   . GLY B 2 105 ? 190.936 230.851 324.810 1.00 57.66  ? 105 GLY B O   1 
ATOM 1718 N N   . ARG B 2 106 ? 191.438 230.545 326.978 1.00 54.04  ? 106 ARG B N   1 
ATOM 1719 C CA  . ARG B 2 106 ? 192.818 230.142 326.741 1.00 53.55  ? 106 ARG B CA  1 
ATOM 1720 C C   . ARG B 2 106 ? 193.043 228.751 327.312 1.00 54.70  ? 106 ARG B C   1 
ATOM 1721 O O   . ARG B 2 106 ? 192.833 228.525 328.508 1.00 58.33  ? 106 ARG B O   1 
ATOM 1722 C CB  . ARG B 2 106 ? 193.792 231.141 327.367 1.00 56.75  ? 106 ARG B CB  1 
ATOM 1723 C CG  . ARG B 2 106 ? 193.972 232.415 326.560 1.00 60.70  ? 106 ARG B CG  1 
ATOM 1724 C CD  . ARG B 2 106 ? 194.742 232.164 325.276 1.00 59.71  ? 106 ARG B CD  1 
ATOM 1725 N NE  . ARG B 2 106 ? 196.060 231.600 325.536 1.00 58.28  ? 106 ARG B NE  1 
ATOM 1726 C CZ  . ARG B 2 106 ? 197.121 232.309 325.897 1.00 55.36  ? 106 ARG B CZ  1 
ATOM 1727 N NH1 . ARG B 2 106 ? 197.055 233.619 326.060 1.00 50.75  ? 106 ARG B NH1 1 
ATOM 1728 N NH2 . ARG B 2 106 ? 198.277 231.686 326.103 1.00 58.51  ? 106 ARG B NH2 1 
ATOM 1729 N N   . TRP B 2 107 ? 193.472 227.831 326.459 1.00 60.76  ? 107 TRP B N   1 
ATOM 1730 C CA  . TRP B 2 107 ? 193.795 226.478 326.882 1.00 60.21  ? 107 TRP B CA  1 
ATOM 1731 C C   . TRP B 2 107 ? 195.178 226.452 327.535 1.00 62.04  ? 107 TRP B C   1 
ATOM 1732 O O   . TRP B 2 107 ? 196.083 227.162 327.091 1.00 63.96  ? 107 TRP B O   1 
ATOM 1733 C CB  . TRP B 2 107 ? 193.770 225.534 325.684 1.00 57.96  ? 107 TRP B CB  1 
ATOM 1734 C CG  . TRP B 2 107 ? 193.469 224.115 326.030 1.00 60.07  ? 107 TRP B CG  1 
ATOM 1735 C CD1 . TRP B 2 107 ? 194.367 223.137 326.330 1.00 56.29  ? 107 TRP B CD1 1 
ATOM 1736 C CD2 . TRP B 2 107 ? 192.175 223.510 326.105 1.00 61.34  ? 107 TRP B CD2 1 
ATOM 1737 N NE1 . TRP B 2 107 ? 193.713 221.960 326.591 1.00 54.73  ? 107 TRP B NE1 1 
ATOM 1738 C CE2 . TRP B 2 107 ? 192.365 222.163 326.460 1.00 59.07  ? 107 TRP B CE2 1 
ATOM 1739 C CE3 . TRP B 2 107 ? 190.874 223.978 325.907 1.00 57.20  ? 107 TRP B CE3 1 
ATOM 1740 C CZ2 . TRP B 2 107 ? 191.304 221.278 326.621 1.00 59.60  ? 107 TRP B CZ2 1 
ATOM 1741 C CZ3 . TRP B 2 107 ? 189.822 223.099 326.068 1.00 57.16  ? 107 TRP B CZ3 1 
ATOM 1742 C CH2 . TRP B 2 107 ? 190.043 221.765 326.422 1.00 59.04  ? 107 TRP B CH2 1 
ATOM 1743 N N   . PRO B 2 108 ? 195.377 225.652 328.584 1.00 60.75  ? 108 PRO B N   1 
ATOM 1744 C CA  . PRO B 2 108 ? 196.720 225.546 329.170 1.00 60.91  ? 108 PRO B CA  1 
ATOM 1745 C C   . PRO B 2 108 ? 197.694 224.931 328.177 1.00 66.48  ? 108 PRO B C   1 
ATOM 1746 O O   . PRO B 2 108 ? 197.448 223.854 327.631 1.00 67.51  ? 108 PRO B O   1 
ATOM 1747 C CB  . PRO B 2 108 ? 196.508 224.645 330.391 1.00 59.88  ? 108 PRO B CB  1 
ATOM 1748 C CG  . PRO B 2 108 ? 195.260 223.906 330.109 1.00 61.22  ? 108 PRO B CG  1 
ATOM 1749 C CD  . PRO B 2 108 ? 194.398 224.843 329.327 1.00 60.41  ? 108 PRO B CD  1 
ATOM 1750 N N   . GLU B 2 109 ? 198.809 225.622 327.952 1.00 80.50  ? 109 GLU B N   1 
ATOM 1751 C CA  . GLU B 2 109 ? 199.782 225.227 326.948 1.00 77.24  ? 109 GLU B CA  1 
ATOM 1752 C C   . GLU B 2 109 ? 201.181 225.235 327.543 1.00 76.65  ? 109 GLU B C   1 
ATOM 1753 O O   . GLU B 2 109 ? 201.464 225.952 328.506 1.00 75.26  ? 109 GLU B O   1 
ATOM 1754 C CB  . GLU B 2 109 ? 199.733 226.155 325.731 1.00 75.17  ? 109 GLU B CB  1 
ATOM 1755 C CG  . GLU B 2 109 ? 198.475 226.001 324.896 1.00 76.99  ? 109 GLU B CG  1 
ATOM 1756 C CD  . GLU B 2 109 ? 198.393 224.652 324.209 1.00 80.39  ? 109 GLU B CD  1 
ATOM 1757 O OE1 . GLU B 2 109 ? 199.450 224.015 324.021 1.00 77.78  ? 109 GLU B OE1 1 
ATOM 1758 O OE2 . GLU B 2 109 ? 197.272 224.227 323.859 1.00 79.37  ? 109 GLU B OE2 1 
ATOM 1759 N N   . TYR B 2 110 ? 202.053 224.424 326.952 1.00 78.64  ? 110 TYR B N   1 
ATOM 1760 C CA  . TYR B 2 110 ? 203.427 224.324 327.417 1.00 79.50  ? 110 TYR B CA  1 
ATOM 1761 C C   . TYR B 2 110 ? 204.175 225.625 327.166 1.00 84.18  ? 110 TYR B C   1 
ATOM 1762 O O   . TYR B 2 110 ? 203.956 226.303 326.159 1.00 86.91  ? 110 TYR B O   1 
ATOM 1763 C CB  . TYR B 2 110 ? 204.137 223.174 326.710 1.00 81.81  ? 110 TYR B CB  1 
ATOM 1764 C CG  . TYR B 2 110 ? 203.603 221.811 327.073 1.00 78.64  ? 110 TYR B CG  1 
ATOM 1765 C CD1 . TYR B 2 110 ? 202.508 221.277 326.411 1.00 78.95  ? 110 TYR B CD1 1 
ATOM 1766 C CD2 . TYR B 2 110 ? 204.197 221.056 328.074 1.00 78.18  ? 110 TYR B CD2 1 
ATOM 1767 C CE1 . TYR B 2 110 ? 202.016 220.033 326.738 1.00 82.47  ? 110 TYR B CE1 1 
ATOM 1768 C CE2 . TYR B 2 110 ? 203.713 219.810 328.407 1.00 82.08  ? 110 TYR B CE2 1 
ATOM 1769 C CZ  . TYR B 2 110 ? 202.622 219.302 327.736 1.00 85.10  ? 110 TYR B CZ  1 
ATOM 1770 O OH  . TYR B 2 110 ? 202.134 218.059 328.064 1.00 81.62  ? 110 TYR B OH  1 
ATOM 1771 N N   . LEU B 2 111 ? 205.069 225.968 328.088 1.00 79.77  ? 111 LEU B N   1 
ATOM 1772 C CA  . LEU B 2 111 ? 205.912 227.139 327.905 1.00 76.02  ? 111 LEU B CA  1 
ATOM 1773 C C   . LEU B 2 111 ? 206.811 226.953 326.690 1.00 79.19  ? 111 LEU B C   1 
ATOM 1774 O O   . LEU B 2 111 ? 207.345 225.866 326.452 1.00 71.14  ? 111 LEU B O   1 
ATOM 1775 C CB  . LEU B 2 111 ? 206.756 227.380 329.156 1.00 74.81  ? 111 LEU B CB  1 
ATOM 1776 C CG  . LEU B 2 111 ? 207.817 228.477 329.094 1.00 80.06  ? 111 LEU B CG  1 
ATOM 1777 C CD1 . LEU B 2 111 ? 207.203 229.823 328.746 1.00 76.63  ? 111 LEU B CD1 1 
ATOM 1778 C CD2 . LEU B 2 111 ? 208.551 228.551 330.421 1.00 77.62  ? 111 LEU B CD2 1 
ATOM 1779 N N   . ARG B 2 112 ? 206.971 228.020 325.916 1.00 88.22  ? 112 ARG B N   1 
ATOM 1780 C CA  . ARG B 2 112 ? 207.817 227.986 324.731 1.00 88.44  ? 112 ARG B CA  1 
ATOM 1781 C C   . ARG B 2 112 ? 209.050 228.862 324.929 1.00 87.98  ? 112 ARG B C   1 
ATOM 1782 O O   . ARG B 2 112 ? 210.041 228.433 325.521 1.00 86.43  ? 112 ARG B O   1 
ATOM 1783 C CB  . ARG B 2 112 ? 207.039 228.447 323.498 1.00 85.61  ? 112 ARG B CB  1 
ATOM 1784 C CG  . ARG B 2 112 ? 205.632 227.874 323.386 1.00 85.09  ? 112 ARG B CG  1 
ATOM 1785 C CD  . ARG B 2 112 ? 205.611 226.352 323.424 1.00 87.27  ? 112 ARG B CD  1 
ATOM 1786 N NE  . ARG B 2 112 ? 206.596 225.755 322.527 1.00 89.00  ? 112 ARG B NE  1 
ATOM 1787 C CZ  . ARG B 2 112 ? 207.607 224.981 322.906 1.00 87.55  ? 112 ARG B CZ  1 
ATOM 1788 N NH1 . ARG B 2 112 ? 207.796 224.649 324.174 1.00 82.62  ? 112 ARG B NH1 1 
ATOM 1789 N NH2 . ARG B 2 112 ? 208.447 224.519 321.985 1.00 87.64  ? 112 ARG B NH2 1 
ATOM 1790 N N   . PRO B 2 122 ? 212.956 222.790 330.729 1.00 91.02  ? 122 PRO B N   1 
ATOM 1791 C CA  . PRO B 2 122 ? 211.812 222.328 331.522 1.00 92.63  ? 122 PRO B CA  1 
ATOM 1792 C C   . PRO B 2 122 ? 211.768 220.810 331.649 1.00 93.55  ? 122 PRO B C   1 
ATOM 1793 O O   . PRO B 2 122 ? 212.811 220.159 331.612 1.00 93.10  ? 122 PRO B O   1 
ATOM 1794 C CB  . PRO B 2 122 ? 210.607 222.848 330.733 1.00 91.72  ? 122 PRO B CB  1 
ATOM 1795 C CG  . PRO B 2 122 ? 211.125 224.008 329.969 1.00 91.13  ? 122 PRO B CG  1 
ATOM 1796 C CD  . PRO B 2 122 ? 212.540 223.666 329.622 1.00 90.80  ? 122 PRO B CD  1 
ATOM 1797 N N   . THR B 2 123 ? 210.566 220.259 331.803 1.00 102.38 ? 123 THR B N   1 
ATOM 1798 C CA  . THR B 2 123 ? 210.366 218.818 331.865 1.00 103.31 ? 123 THR B CA  1 
ATOM 1799 C C   . THR B 2 123 ? 209.066 218.491 331.137 1.00 101.83 ? 123 THR B C   1 
ATOM 1800 O O   . THR B 2 123 ? 208.491 219.332 330.440 1.00 100.26 ? 123 THR B O   1 
ATOM 1801 C CB  . THR B 2 123 ? 210.346 218.326 333.320 1.00 102.95 ? 123 THR B CB  1 
ATOM 1802 O OG1 . THR B 2 123 ? 209.331 219.024 334.052 1.00 103.45 ? 123 THR B OG1 1 
ATOM 1803 C CG2 . THR B 2 123 ? 211.700 218.547 333.986 1.00 97.64  ? 123 THR B CG2 1 
ATOM 1804 N N   . GLU B 2 124 ? 208.607 217.254 331.293 1.00 111.47 ? 124 GLU B N   1 
ATOM 1805 C CA  . GLU B 2 124 ? 207.331 216.822 330.741 1.00 113.14 ? 124 GLU B CA  1 
ATOM 1806 C C   . GLU B 2 124 ? 206.844 215.611 331.529 1.00 113.12 ? 124 GLU B C   1 
ATOM 1807 O O   . GLU B 2 124 ? 207.105 214.467 331.135 1.00 110.63 ? 124 GLU B O   1 
ATOM 1808 C CB  . GLU B 2 124 ? 207.465 216.494 329.254 1.00 112.16 ? 124 GLU B CB  1 
ATOM 1809 C CG  . GLU B 2 124 ? 206.136 216.337 328.534 1.00 111.27 ? 124 GLU B CG  1 
ATOM 1810 C CD  . GLU B 2 124 ? 206.292 216.297 327.026 1.00 111.74 ? 124 GLU B CD  1 
ATOM 1811 O OE1 . GLU B 2 124 ? 207.445 216.298 326.546 1.00 110.06 ? 124 GLU B OE1 1 
ATOM 1812 O OE2 . GLU B 2 124 ? 205.262 216.268 326.322 1.00 110.73 ? 124 GLU B OE2 1 
ATOM 1813 N N   . PRO B 2 125 ? 206.140 215.819 332.644 1.00 109.93 ? 125 PRO B N   1 
ATOM 1814 C CA  . PRO B 2 125 ? 205.780 214.682 333.507 1.00 107.35 ? 125 PRO B CA  1 
ATOM 1815 C C   . PRO B 2 125 ? 204.907 213.647 332.827 1.00 104.90 ? 125 PRO B C   1 
ATOM 1816 O O   . PRO B 2 125 ? 204.842 212.507 333.304 1.00 105.14 ? 125 PRO B O   1 
ATOM 1817 C CB  . PRO B 2 125 ? 205.046 215.350 334.678 1.00 105.63 ? 125 PRO B CB  1 
ATOM 1818 C CG  . PRO B 2 125 ? 205.524 216.761 334.672 1.00 104.63 ? 125 PRO B CG  1 
ATOM 1819 C CD  . PRO B 2 125 ? 205.729 217.104 333.233 1.00 104.84 ? 125 PRO B CD  1 
ATOM 1820 N N   . GLU B 2 126 ? 204.230 214.001 331.736 1.00 112.01 ? 126 GLU B N   1 
ATOM 1821 C CA  . GLU B 2 126 ? 203.356 213.061 331.047 1.00 114.81 ? 126 GLU B CA  1 
ATOM 1822 C C   . GLU B 2 126 ? 202.316 212.521 332.024 1.00 115.06 ? 126 GLU B C   1 
ATOM 1823 O O   . GLU B 2 126 ? 201.399 213.252 332.409 1.00 110.49 ? 126 GLU B O   1 
ATOM 1824 C CB  . GLU B 2 126 ? 204.179 211.936 330.410 1.00 115.02 ? 126 GLU B CB  1 
ATOM 1825 C CG  . GLU B 2 126 ? 203.373 210.987 329.531 1.00 115.04 ? 126 GLU B CG  1 
ATOM 1826 C CD  . GLU B 2 126 ? 202.673 211.695 328.385 1.00 113.08 ? 126 GLU B CD  1 
ATOM 1827 O OE1 . GLU B 2 126 ? 203.091 212.818 328.031 1.00 110.23 ? 126 GLU B OE1 1 
ATOM 1828 O OE2 . GLU B 2 126 ? 201.702 211.129 327.840 1.00 112.49 ? 126 GLU B OE2 1 
ATOM 1829 N N   . VAL B 2 127 ? 202.437 211.258 332.436 1.00 115.03 ? 127 VAL B N   1 
ATOM 1830 C CA  . VAL B 2 127 ? 201.495 210.660 333.375 1.00 111.79 ? 127 VAL B CA  1 
ATOM 1831 C C   . VAL B 2 127 ? 202.026 210.691 334.805 1.00 110.60 ? 127 VAL B C   1 
ATOM 1832 O O   . VAL B 2 127 ? 201.346 210.230 335.725 1.00 107.41 ? 127 VAL B O   1 
ATOM 1833 C CB  . VAL B 2 127 ? 201.138 209.224 332.960 1.00 111.69 ? 127 VAL B CB  1 
ATOM 1834 C CG1 . VAL B 2 127 ? 199.969 208.699 333.786 1.00 108.35 ? 127 VAL B CG1 1 
ATOM 1835 C CG2 . VAL B 2 127 ? 200.820 209.162 331.473 1.00 110.91 ? 127 VAL B CG2 1 
ATOM 1836 N N   . ALA B 2 128 ? 203.223 211.240 335.018 1.00 109.47 ? 128 ALA B N   1 
ATOM 1837 C CA  . ALA B 2 128 ? 203.788 211.259 336.362 1.00 108.58 ? 128 ALA B CA  1 
ATOM 1838 C C   . ALA B 2 128 ? 202.890 212.026 337.323 1.00 104.86 ? 128 ALA B C   1 
ATOM 1839 O O   . ALA B 2 128 ? 202.648 211.579 338.449 1.00 103.21 ? 128 ALA B O   1 
ATOM 1840 C CB  . ALA B 2 128 ? 205.189 211.867 336.335 1.00 105.23 ? 128 ALA B CB  1 
ATOM 1841 N N   . ALA B 2 129 ? 202.382 213.181 336.895 1.00 88.18  ? 129 ALA B N   1 
ATOM 1842 C CA  . ALA B 2 129 ? 201.505 213.990 337.725 1.00 89.05  ? 129 ALA B CA  1 
ATOM 1843 C C   . ALA B 2 129 ? 200.166 214.308 337.081 1.00 91.78  ? 129 ALA B C   1 
ATOM 1844 O O   . ALA B 2 129 ? 199.266 214.775 337.788 1.00 89.39  ? 129 ALA B O   1 
ATOM 1845 C CB  . ALA B 2 129 ? 202.190 215.311 338.103 1.00 89.16  ? 129 ALA B CB  1 
ATOM 1846 N N   . CYS B 2 130 ? 199.994 214.066 335.783 1.00 99.95  ? 130 CYS B N   1 
ATOM 1847 C CA  . CYS B 2 130 ? 198.745 214.406 335.113 1.00 98.48  ? 130 CYS B CA  1 
ATOM 1848 C C   . CYS B 2 130 ? 197.683 213.343 335.359 1.00 96.14  ? 130 CYS B C   1 
ATOM 1849 O O   . CYS B 2 130 ? 197.051 212.857 334.415 1.00 95.45  ? 130 CYS B O   1 
ATOM 1850 C CB  . CYS B 2 130 ? 198.976 214.580 333.611 1.00 99.76  ? 130 CYS B CB  1 
ATOM 1851 S SG  . CYS B 2 130 ? 200.251 215.788 333.198 1.00 102.35 ? 130 CYS B SG  1 
ATOM 1852 N N   . ARG B 2 131 ? 197.474 212.983 336.618 1.00 76.94  ? 131 ARG B N   1 
ATOM 1853 C CA  . ARG B 2 131 ? 196.417 212.059 336.994 1.00 76.09  ? 131 ARG B CA  1 
ATOM 1854 C C   . ARG B 2 131 ? 195.140 212.862 337.239 1.00 76.35  ? 131 ARG B C   1 
ATOM 1855 O O   . ARG B 2 131 ? 195.074 214.051 336.919 1.00 77.08  ? 131 ARG B O   1 
ATOM 1856 C CB  . ARG B 2 131 ? 196.844 211.251 338.222 1.00 75.74  ? 131 ARG B CB  1 
ATOM 1857 C CG  . ARG B 2 131 ? 197.870 210.177 337.941 1.00 77.26  ? 131 ARG B CG  1 
ATOM 1858 C CD  . ARG B 2 131 ? 198.451 209.634 339.233 1.00 78.13  ? 131 ARG B CD  1 
ATOM 1859 N NE  . ARG B 2 131 ? 197.534 209.784 340.357 1.00 74.79  ? 131 ARG B NE  1 
ATOM 1860 C CZ  . ARG B 2 131 ? 196.553 208.941 340.647 1.00 75.02  ? 131 ARG B CZ  1 
ATOM 1861 N NH1 . ARG B 2 131 ? 196.317 207.873 339.907 1.00 77.66  ? 131 ARG B NH1 1 
ATOM 1862 N NH2 . ARG B 2 131 ? 195.791 209.175 341.710 1.00 75.50  ? 131 ARG B NH2 1 
ATOM 1863 N N   . PHE B 2 132 ? 194.118 212.229 337.800 1.00 70.72  ? 132 PHE B N   1 
ATOM 1864 C CA  . PHE B 2 132 ? 192.902 212.912 338.229 1.00 69.38  ? 132 PHE B CA  1 
ATOM 1865 C C   . PHE B 2 132 ? 192.819 212.764 339.742 1.00 68.50  ? 132 PHE B C   1 
ATOM 1866 O O   . PHE B 2 132 ? 192.267 211.783 340.248 1.00 74.93  ? 132 PHE B O   1 
ATOM 1867 C CB  . PHE B 2 132 ? 191.674 212.340 337.531 1.00 71.71  ? 132 PHE B CB  1 
ATOM 1868 C CG  . PHE B 2 132 ? 191.406 212.949 336.183 1.00 73.61  ? 132 PHE B CG  1 
ATOM 1869 C CD1 . PHE B 2 132 ? 190.606 214.066 336.065 1.00 72.65  ? 132 PHE B CD1 1 
ATOM 1870 C CD2 . PHE B 2 132 ? 191.950 212.407 335.040 1.00 73.55  ? 132 PHE B CD2 1 
ATOM 1871 C CE1 . PHE B 2 132 ? 190.353 214.631 334.838 1.00 71.02  ? 132 PHE B CE1 1 
ATOM 1872 C CE2 . PHE B 2 132 ? 191.697 212.972 333.809 1.00 75.46  ? 132 PHE B CE2 1 
ATOM 1873 C CZ  . PHE B 2 132 ? 190.900 214.084 333.709 1.00 73.94  ? 132 PHE B CZ  1 
ATOM 1874 N N   . TYR B 2 133 ? 193.368 213.738 340.463 1.00 54.24  ? 133 TYR B N   1 
ATOM 1875 C CA  . TYR B 2 133 ? 193.450 213.677 341.921 1.00 60.38  ? 133 TYR B CA  1 
ATOM 1876 C C   . TYR B 2 133 ? 192.103 214.078 342.500 1.00 61.98  ? 133 TYR B C   1 
ATOM 1877 O O   . TYR B 2 133 ? 191.819 215.253 342.722 1.00 71.20  ? 133 TYR B O   1 
ATOM 1878 C CB  . TYR B 2 133 ? 194.561 214.581 342.435 1.00 60.66  ? 133 TYR B CB  1 
ATOM 1879 C CG  . TYR B 2 133 ? 195.923 214.257 341.875 1.00 64.15  ? 133 TYR B CG  1 
ATOM 1880 C CD1 . TYR B 2 133 ? 196.651 213.182 342.353 1.00 66.36  ? 133 TYR B CD1 1 
ATOM 1881 C CD2 . TYR B 2 133 ? 196.481 215.030 340.872 1.00 67.81  ? 133 TYR B CD2 1 
ATOM 1882 C CE1 . TYR B 2 133 ? 197.895 212.885 341.848 1.00 61.91  ? 133 TYR B CE1 1 
ATOM 1883 C CE2 . TYR B 2 133 ? 197.723 214.740 340.359 1.00 67.37  ? 133 TYR B CE2 1 
ATOM 1884 C CZ  . TYR B 2 133 ? 198.426 213.667 340.851 1.00 66.89  ? 133 TYR B CZ  1 
ATOM 1885 O OH  . TYR B 2 133 ? 199.666 213.377 340.340 1.00 73.03  ? 133 TYR B OH  1 
ATOM 1886 N N   . THR B 2 134 ? 191.265 213.083 342.762 1.00 52.25  ? 134 THR B N   1 
ATOM 1887 C CA  . THR B 2 134 ? 189.936 213.322 343.314 1.00 55.09  ? 134 THR B CA  1 
ATOM 1888 C C   . THR B 2 134 ? 190.066 213.662 344.791 1.00 57.14  ? 134 THR B C   1 
ATOM 1889 O O   . THR B 2 134 ? 190.187 212.776 345.637 1.00 60.48  ? 134 THR B O   1 
ATOM 1890 C CB  . THR B 2 134 ? 189.048 212.101 343.110 1.00 58.34  ? 134 THR B CB  1 
ATOM 1891 O OG1 . THR B 2 134 ? 188.787 211.923 341.713 1.00 59.56  ? 134 THR B OG1 1 
ATOM 1892 C CG2 . THR B 2 134 ? 187.734 212.265 343.849 1.00 58.42  ? 134 THR B CG2 1 
ATOM 1893 N N   . LEU B 2 135 ? 190.034 214.953 345.110 1.00 59.36  ? 135 LEU B N   1 
ATOM 1894 C CA  . LEU B 2 135 ? 190.083 215.370 346.500 1.00 57.16  ? 135 LEU B CA  1 
ATOM 1895 C C   . LEU B 2 135 ? 188.915 214.766 347.271 1.00 65.77  ? 135 LEU B C   1 
ATOM 1896 O O   . LEU B 2 135 ? 187.980 214.201 346.699 1.00 68.85  ? 135 LEU B O   1 
ATOM 1897 C CB  . LEU B 2 135 ? 190.038 216.893 346.612 1.00 53.94  ? 135 LEU B CB  1 
ATOM 1898 C CG  . LEU B 2 135 ? 190.976 217.689 345.707 1.00 59.24  ? 135 LEU B CG  1 
ATOM 1899 C CD1 . LEU B 2 135 ? 191.024 219.132 346.163 1.00 63.87  ? 135 LEU B CD1 1 
ATOM 1900 C CD2 . LEU B 2 135 ? 192.364 217.092 345.691 1.00 65.01  ? 135 LEU B CD2 1 
ATOM 1901 N N   . ASP B 2 136 ? 188.978 214.892 348.593 1.00 77.47  ? 136 ASP B N   1 
ATOM 1902 C CA  . ASP B 2 136 ? 187.903 214.389 349.431 1.00 76.28  ? 136 ASP B CA  1 
ATOM 1903 C C   . ASP B 2 136 ? 186.611 215.146 349.141 1.00 75.46  ? 136 ASP B C   1 
ATOM 1904 O O   . ASP B 2 136 ? 186.615 216.309 348.730 1.00 69.84  ? 136 ASP B O   1 
ATOM 1905 C CB  . ASP B 2 136 ? 188.266 214.519 350.909 1.00 73.89  ? 136 ASP B CB  1 
ATOM 1906 C CG  . ASP B 2 136 ? 188.530 215.954 351.319 1.00 80.40  ? 136 ASP B CG  1 
ATOM 1907 O OD1 . ASP B 2 136 ? 188.545 216.836 350.435 1.00 78.80  ? 136 ASP B OD1 1 
ATOM 1908 O OD2 . ASP B 2 136 ? 188.722 216.201 352.529 1.00 81.42  ? 136 ASP B OD2 1 
ATOM 1909 N N   . THR B 2 137 ? 185.492 214.463 349.351 1.00 64.08  ? 137 THR B N   1 
ATOM 1910 C CA  . THR B 2 137 ? 184.183 215.043 349.108 1.00 56.53  ? 137 THR B CA  1 
ATOM 1911 C C   . THR B 2 137 ? 183.750 215.901 350.290 1.00 56.60  ? 137 THR B C   1 
ATOM 1912 O O   . THR B 2 137 ? 184.114 215.641 351.439 1.00 60.70  ? 137 THR B O   1 
ATOM 1913 C CB  . THR B 2 137 ? 183.143 213.951 348.858 1.00 51.35  ? 137 THR B CB  1 
ATOM 1914 O OG1 . THR B 2 137 ? 181.909 214.551 348.453 1.00 58.18  ? 137 THR B OG1 1 
ATOM 1915 C CG2 . THR B 2 137 ? 182.908 213.133 350.116 1.00 53.74  ? 137 THR B CG2 1 
ATOM 1916 N N   . VAL B 2 138 ? 182.965 216.932 349.991 1.00 48.46  ? 138 VAL B N   1 
ATOM 1917 C CA  . VAL B 2 138 ? 182.407 217.829 350.996 1.00 47.23  ? 138 VAL B CA  1 
ATOM 1918 C C   . VAL B 2 138 ? 180.892 217.714 350.937 1.00 57.30  ? 138 VAL B C   1 
ATOM 1919 O O   . VAL B 2 138 ? 180.304 217.775 349.853 1.00 54.70  ? 138 VAL B O   1 
ATOM 1920 C CB  . VAL B 2 138 ? 182.858 219.283 350.777 1.00 50.96  ? 138 VAL B CB  1 
ATOM 1921 C CG1 . VAL B 2 138 ? 184.320 219.435 351.133 1.00 57.74  ? 138 VAL B CG1 1 
ATOM 1922 C CG2 . VAL B 2 138 ? 182.620 219.709 349.342 1.00 57.80  ? 138 VAL B CG2 1 
ATOM 1923 N N   . SER B 2 139 ? 180.265 217.534 352.094 1.00 60.09  ? 139 SER B N   1 
ATOM 1924 C CA  . SER B 2 139 ? 178.831 217.270 352.162 1.00 54.41  ? 139 SER B CA  1 
ATOM 1925 C C   . SER B 2 139 ? 178.086 218.598 352.184 1.00 50.79  ? 139 SER B C   1 
ATOM 1926 O O   . SER B 2 139 ? 178.036 219.279 353.210 1.00 48.11  ? 139 SER B O   1 
ATOM 1927 C CB  . SER B 2 139 ? 178.500 216.428 353.388 1.00 56.37  ? 139 SER B CB  1 
ATOM 1928 O OG  . SER B 2 139 ? 178.761 217.145 354.580 1.00 58.95  ? 139 SER B OG  1 
ATOM 1929 N N   . TRP B 2 140 ? 177.510 218.971 351.045 1.00 52.42  ? 140 TRP B N   1 
ATOM 1930 C CA  . TRP B 2 140 ? 176.627 220.123 350.989 1.00 44.28  ? 140 TRP B CA  1 
ATOM 1931 C C   . TRP B 2 140 ? 175.366 219.833 351.789 1.00 43.28  ? 140 TRP B C   1 
ATOM 1932 O O   . TRP B 2 140 ? 174.715 218.800 351.591 1.00 56.71  ? 140 TRP B O   1 
ATOM 1933 C CB  . TRP B 2 140 ? 176.279 220.432 349.535 1.00 38.01  ? 140 TRP B CB  1 
ATOM 1934 C CG  . TRP B 2 140 ? 175.438 221.647 349.321 1.00 34.63  ? 140 TRP B CG  1 
ATOM 1935 C CD1 . TRP B 2 140 ? 175.076 222.573 350.247 1.00 49.09  ? 140 TRP B CD1 1 
ATOM 1936 C CD2 . TRP B 2 140 ? 174.856 222.068 348.085 1.00 43.56  ? 140 TRP B CD2 1 
ATOM 1937 N NE1 . TRP B 2 140 ? 174.302 223.546 349.667 1.00 52.31  ? 140 TRP B NE1 1 
ATOM 1938 C CE2 . TRP B 2 140 ? 174.154 223.257 348.338 1.00 48.04  ? 140 TRP B CE2 1 
ATOM 1939 C CE3 . TRP B 2 140 ? 174.862 221.553 346.789 1.00 39.79  ? 140 TRP B CE3 1 
ATOM 1940 C CZ2 . TRP B 2 140 ? 173.463 223.937 347.345 1.00 47.20  ? 140 TRP B CZ2 1 
ATOM 1941 C CZ3 . TRP B 2 140 ? 174.176 222.226 345.807 1.00 47.56  ? 140 TRP B CZ3 1 
ATOM 1942 C CH2 . TRP B 2 140 ? 173.488 223.408 346.087 1.00 47.38  ? 140 TRP B CH2 1 
ATOM 1943 N N   . THR B 2 141 ? 175.026 220.748 352.693 1.00 49.02  ? 141 THR B N   1 
ATOM 1944 C CA  . THR B 2 141 ? 173.858 220.642 353.551 1.00 53.37  ? 141 THR B CA  1 
ATOM 1945 C C   . THR B 2 141 ? 173.058 221.933 353.452 1.00 56.35  ? 141 THR B C   1 
ATOM 1946 O O   . THR B 2 141 ? 173.396 222.843 352.691 1.00 61.88  ? 141 THR B O   1 
ATOM 1947 C CB  . THR B 2 141 ? 174.256 220.370 355.006 1.00 54.08  ? 141 THR B CB  1 
ATOM 1948 O OG1 . THR B 2 141 ? 174.682 221.590 355.621 1.00 55.30  ? 141 THR B OG1 1 
ATOM 1949 C CG2 . THR B 2 141 ? 175.386 219.367 355.066 1.00 53.42  ? 141 THR B CG2 1 
ATOM 1950 N N   . LYS B 2 142 ? 171.983 222.013 354.236 1.00 65.64  ? 142 LYS B N   1 
ATOM 1951 C CA  . LYS B 2 142 ? 171.122 223.188 354.208 1.00 68.17  ? 142 LYS B CA  1 
ATOM 1952 C C   . LYS B 2 142 ? 171.721 224.384 354.935 1.00 67.04  ? 142 LYS B C   1 
ATOM 1953 O O   . LYS B 2 142 ? 171.169 225.483 354.830 1.00 73.49  ? 142 LYS B O   1 
ATOM 1954 C CB  . LYS B 2 142 ? 169.761 222.847 354.815 1.00 65.75  ? 142 LYS B CB  1 
ATOM 1955 C CG  . LYS B 2 142 ? 168.981 221.820 354.013 1.00 70.22  ? 142 LYS B CG  1 
ATOM 1956 C CD  . LYS B 2 142 ? 167.656 221.467 354.668 1.00 73.00  ? 142 LYS B CD  1 
ATOM 1957 C CE  . LYS B 2 142 ? 166.688 222.638 354.656 1.00 75.12  ? 142 LYS B CE  1 
ATOM 1958 N NZ  . LYS B 2 142 ? 165.323 222.232 355.090 1.00 70.77  ? 142 LYS B NZ  1 
ATOM 1959 N N   . GLU B 2 143 ? 172.825 224.205 355.662 1.00 66.57  ? 143 GLU B N   1 
ATOM 1960 C CA  . GLU B 2 143 ? 173.459 225.297 356.386 1.00 67.25  ? 143 GLU B CA  1 
ATOM 1961 C C   . GLU B 2 143 ? 174.803 225.720 355.817 1.00 70.58  ? 143 GLU B C   1 
ATOM 1962 O O   . GLU B 2 143 ? 175.232 226.847 356.083 1.00 70.39  ? 143 GLU B O   1 
ATOM 1963 C CB  . GLU B 2 143 ? 173.663 224.921 357.862 1.00 64.45  ? 143 GLU B CB  1 
ATOM 1964 C CG  . GLU B 2 143 ? 172.412 224.411 358.558 1.00 69.31  ? 143 GLU B CG  1 
ATOM 1965 C CD  . GLU B 2 143 ? 172.421 222.908 358.761 1.00 75.13  ? 143 GLU B CD  1 
ATOM 1966 O OE1 . GLU B 2 143 ? 173.192 222.211 358.070 1.00 73.43  ? 143 GLU B OE1 1 
ATOM 1967 O OE2 . GLU B 2 143 ? 171.655 222.422 359.620 1.00 75.70  ? 143 GLU B OE2 1 
ATOM 1968 N N   . SER B 2 144 ? 175.473 224.865 355.049 1.00 67.61  ? 144 SER B N   1 
ATOM 1969 C CA  . SER B 2 144 ? 176.808 225.184 354.564 1.00 66.22  ? 144 SER B CA  1 
ATOM 1970 C C   . SER B 2 144 ? 176.783 226.459 353.734 1.00 65.33  ? 144 SER B C   1 
ATOM 1971 O O   . SER B 2 144 ? 175.854 226.696 352.959 1.00 61.58  ? 144 SER B O   1 
ATOM 1972 C CB  . SER B 2 144 ? 177.356 224.027 353.732 1.00 59.66  ? 144 SER B CB  1 
ATOM 1973 O OG  . SER B 2 144 ? 176.565 223.822 352.578 1.00 65.42  ? 144 SER B OG  1 
ATOM 1974 N N   . ARG B 2 145 ? 177.817 227.283 353.902 1.00 60.14  ? 145 ARG B N   1 
ATOM 1975 C CA  . ARG B 2 145 ? 177.902 228.570 353.227 1.00 58.65  ? 145 ARG B CA  1 
ATOM 1976 C C   . ARG B 2 145 ? 178.884 228.597 352.069 1.00 56.54  ? 145 ARG B C   1 
ATOM 1977 O O   . ARG B 2 145 ? 178.721 229.420 351.167 1.00 55.61  ? 145 ARG B O   1 
ATOM 1978 C CB  . ARG B 2 145 ? 178.288 229.668 354.225 1.00 62.11  ? 145 ARG B CB  1 
ATOM 1979 C CG  . ARG B 2 145 ? 177.176 230.049 355.194 1.00 61.48  ? 145 ARG B CG  1 
ATOM 1980 C CD  . ARG B 2 145 ? 175.970 230.629 354.465 1.00 63.21  ? 145 ARG B CD  1 
ATOM 1981 N NE  . ARG B 2 145 ? 174.884 230.976 355.373 1.00 64.88  ? 145 ARG B NE  1 
ATOM 1982 C CZ  . ARG B 2 145 ? 173.620 231.127 354.999 1.00 64.49  ? 145 ARG B CZ  1 
ATOM 1983 N NH1 . ARG B 2 145 ? 173.244 230.954 353.742 1.00 63.73  ? 145 ARG B NH1 1 
ATOM 1984 N NH2 . ARG B 2 145 ? 172.710 231.455 355.911 1.00 63.92  ? 145 ARG B NH2 1 
ATOM 1985 N N   . GLY B 2 146 ? 179.893 227.740 352.066 1.00 52.58  ? 146 GLY B N   1 
ATOM 1986 C CA  . GLY B 2 146 ? 180.819 227.709 350.954 1.00 55.64  ? 146 GLY B CA  1 
ATOM 1987 C C   . GLY B 2 146 ? 182.036 226.877 351.283 1.00 54.36  ? 146 GLY B C   1 
ATOM 1988 O O   . GLY B 2 146 ? 182.214 226.400 352.407 1.00 56.05  ? 146 GLY B O   1 
ATOM 1989 N N   . TRP B 2 147 ? 182.873 226.705 350.263 1.00 50.62  ? 147 TRP B N   1 
ATOM 1990 C CA  . TRP B 2 147 ? 184.122 225.970 350.407 1.00 58.54  ? 147 TRP B CA  1 
ATOM 1991 C C   . TRP B 2 147 ? 185.143 226.559 349.449 1.00 63.45  ? 147 TRP B C   1 
ATOM 1992 O O   . TRP B 2 147 ? 184.847 226.756 348.270 1.00 72.04  ? 147 TRP B O   1 
ATOM 1993 C CB  . TRP B 2 147 ? 183.936 224.475 350.118 1.00 58.73  ? 147 TRP B CB  1 
ATOM 1994 C CG  . TRP B 2 147 ? 182.810 223.852 350.876 1.00 57.73  ? 147 TRP B CG  1 
ATOM 1995 C CD1 . TRP B 2 147 ? 182.854 223.343 352.138 1.00 58.64  ? 147 TRP B CD1 1 
ATOM 1996 C CD2 . TRP B 2 147 ? 181.466 223.677 350.419 1.00 56.47  ? 147 TRP B CD2 1 
ATOM 1997 N NE1 . TRP B 2 147 ? 181.620 222.861 352.497 1.00 60.10  ? 147 TRP B NE1 1 
ATOM 1998 C CE2 . TRP B 2 147 ? 180.751 223.056 351.457 1.00 53.69  ? 147 TRP B CE2 1 
ATOM 1999 C CE3 . TRP B 2 147 ? 180.800 223.986 349.233 1.00 53.84  ? 147 TRP B CE3 1 
ATOM 2000 C CZ2 . TRP B 2 147 ? 179.404 222.738 351.344 1.00 51.22  ? 147 TRP B CZ2 1 
ATOM 2001 C CZ3 . TRP B 2 147 ? 179.465 223.671 349.123 1.00 47.81  ? 147 TRP B CZ3 1 
ATOM 2002 C CH2 . TRP B 2 147 ? 178.780 223.054 350.171 1.00 54.41  ? 147 TRP B CH2 1 
ATOM 2003 N N   . TRP B 2 148 ? 186.346 226.826 349.946 1.00 63.22  ? 148 TRP B N   1 
ATOM 2004 C CA  . TRP B 2 148 ? 187.395 227.432 349.137 1.00 62.46  ? 148 TRP B CA  1 
ATOM 2005 C C   . TRP B 2 148 ? 188.644 226.567 349.166 1.00 66.97  ? 148 TRP B C   1 
ATOM 2006 O O   . TRP B 2 148 ? 189.165 226.252 350.240 1.00 70.58  ? 148 TRP B O   1 
ATOM 2007 C CB  . TRP B 2 148 ? 187.715 228.847 349.623 1.00 66.11  ? 148 TRP B CB  1 
ATOM 2008 C CG  . TRP B 2 148 ? 188.160 228.921 351.040 1.00 69.07  ? 148 TRP B CG  1 
ATOM 2009 C CD1 . TRP B 2 148 ? 187.370 228.905 352.149 1.00 71.18  ? 148 TRP B CD1 1 
ATOM 2010 C CD2 . TRP B 2 148 ? 189.506 229.039 351.507 1.00 70.24  ? 148 TRP B CD2 1 
ATOM 2011 N NE1 . TRP B 2 148 ? 188.141 229.002 353.280 1.00 70.20  ? 148 TRP B NE1 1 
ATOM 2012 C CE2 . TRP B 2 148 ? 189.457 229.084 352.912 1.00 71.11  ? 148 TRP B CE2 1 
ATOM 2013 C CE3 . TRP B 2 148 ? 190.749 229.110 350.872 1.00 69.56  ? 148 TRP B CE3 1 
ATOM 2014 C CZ2 . TRP B 2 148 ? 190.601 229.194 353.693 1.00 74.13  ? 148 TRP B CZ2 1 
ATOM 2015 C CZ3 . TRP B 2 148 ? 191.882 229.219 351.647 1.00 67.89  ? 148 TRP B CZ3 1 
ATOM 2016 C CH2 . TRP B 2 148 ? 191.802 229.261 353.043 1.00 73.32  ? 148 TRP B CH2 1 
ATOM 2017 N N   . TRP B 2 149 ? 189.111 226.182 347.982 1.00 61.63  ? 149 TRP B N   1 
ATOM 2018 C CA  . TRP B 2 149 ? 190.379 225.496 347.799 1.00 61.94  ? 149 TRP B CA  1 
ATOM 2019 C C   . TRP B 2 149 ? 191.324 226.426 347.059 1.00 63.15  ? 149 TRP B C   1 
ATOM 2020 O O   . TRP B 2 149 ? 190.889 227.365 346.389 1.00 65.05  ? 149 TRP B O   1 
ATOM 2021 C CB  . TRP B 2 149 ? 190.223 224.195 347.001 1.00 64.42  ? 149 TRP B CB  1 
ATOM 2022 C CG  . TRP B 2 149 ? 189.446 223.139 347.702 1.00 59.92  ? 149 TRP B CG  1 
ATOM 2023 C CD1 . TRP B 2 149 ? 189.943 222.124 348.457 1.00 53.41  ? 149 TRP B CD1 1 
ATOM 2024 C CD2 . TRP B 2 149 ? 188.025 222.989 347.711 1.00 57.01  ? 149 TRP B CD2 1 
ATOM 2025 N NE1 . TRP B 2 149 ? 188.920 221.350 348.940 1.00 57.78  ? 149 TRP B NE1 1 
ATOM 2026 C CE2 . TRP B 2 149 ? 187.731 221.862 348.495 1.00 57.53  ? 149 TRP B CE2 1 
ATOM 2027 C CE3 . TRP B 2 149 ? 186.973 223.701 347.134 1.00 53.48  ? 149 TRP B CE3 1 
ATOM 2028 C CZ2 . TRP B 2 149 ? 186.432 221.429 348.716 1.00 60.48  ? 149 TRP B CZ2 1 
ATOM 2029 C CZ3 . TRP B 2 149 ? 185.685 223.271 347.354 1.00 56.21  ? 149 TRP B CZ3 1 
ATOM 2030 C CH2 . TRP B 2 149 ? 185.424 222.146 348.137 1.00 58.20  ? 149 TRP B CH2 1 
ATOM 2031 N N   . LYS B 2 150 ? 192.620 226.160 347.179 1.00 64.25  ? 150 LYS B N   1 
ATOM 2032 C CA  . LYS B 2 150 ? 193.631 226.934 346.476 1.00 61.60  ? 150 LYS B CA  1 
ATOM 2033 C C   . LYS B 2 150 ? 194.563 225.991 345.739 1.00 59.90  ? 150 LYS B C   1 
ATOM 2034 O O   . LYS B 2 150 ? 194.932 224.939 346.268 1.00 68.37  ? 150 LYS B O   1 
ATOM 2035 C CB  . LYS B 2 150 ? 194.425 227.820 347.436 1.00 62.65  ? 150 LYS B CB  1 
ATOM 2036 C CG  . LYS B 2 150 ? 193.638 229.006 347.957 1.00 63.20  ? 150 LYS B CG  1 
ATOM 2037 C CD  . LYS B 2 150 ? 194.560 230.123 348.391 1.00 64.67  ? 150 LYS B CD  1 
ATOM 2038 C CE  . LYS B 2 150 ? 193.780 231.310 348.918 1.00 68.06  ? 150 LYS B CE  1 
ATOM 2039 N NZ  . LYS B 2 150 ? 194.672 232.411 349.370 1.00 68.19  ? 150 LYS B NZ  1 
ATOM 2040 N N   . LEU B 2 151 ? 194.934 226.366 344.536 1.00 59.14  ? 151 LEU B N   1 
ATOM 2041 C CA  . LEU B 2 151 ? 195.846 225.580 343.730 1.00 62.73  ? 151 LEU B CA  1 
ATOM 2042 C C   . LEU B 2 151 ? 197.183 226.296 343.586 1.00 66.44  ? 151 LEU B C   1 
ATOM 2043 O O   . LEU B 2 151 ? 197.229 227.526 343.503 1.00 70.85  ? 151 LEU B O   1 
ATOM 2044 C CB  . LEU B 2 151 ? 195.261 225.332 342.340 1.00 58.82  ? 151 LEU B CB  1 
ATOM 2045 C CG  . LEU B 2 151 ? 193.872 224.704 342.309 1.00 58.86  ? 151 LEU B CG  1 
ATOM 2046 C CD1 . LEU B 2 151 ? 193.405 224.558 340.877 1.00 63.22  ? 151 LEU B CD1 1 
ATOM 2047 C CD2 . LEU B 2 151 ? 193.875 223.363 343.011 1.00 54.54  ? 151 LEU B CD2 1 
ATOM 2048 N N   . PRO B 2 152 ? 198.300 225.562 343.550 1.00 63.19  ? 152 PRO B N   1 
ATOM 2049 C CA  . PRO B 2 152 ? 198.432 224.105 343.661 1.00 63.90  ? 152 PRO B CA  1 
ATOM 2050 C C   . PRO B 2 152 ? 198.472 223.651 345.113 1.00 70.33  ? 152 PRO B C   1 
ATOM 2051 O O   . PRO B 2 152 ? 198.721 222.484 345.391 1.00 72.48  ? 152 PRO B O   1 
ATOM 2052 C CB  . PRO B 2 152 ? 199.752 223.833 342.941 1.00 69.46  ? 152 PRO B CB  1 
ATOM 2053 C CG  . PRO B 2 152 ? 200.572 225.052 343.234 1.00 71.70  ? 152 PRO B CG  1 
ATOM 2054 C CD  . PRO B 2 152 ? 199.597 226.201 343.270 1.00 63.43  ? 152 PRO B CD  1 
ATOM 2055 N N   . ASP B 2 153 ? 198.224 224.558 346.061 1.00 74.66  ? 153 ASP B N   1 
ATOM 2056 C CA  . ASP B 2 153 ? 198.317 224.201 347.472 1.00 75.91  ? 153 ASP B CA  1 
ATOM 2057 C C   . ASP B 2 153 ? 197.441 223.006 347.813 1.00 79.32  ? 153 ASP B C   1 
ATOM 2058 O O   . ASP B 2 153 ? 197.780 222.225 348.707 1.00 80.97  ? 153 ASP B O   1 
ATOM 2059 C CB  . ASP B 2 153 ? 197.924 225.393 348.341 1.00 78.80  ? 153 ASP B CB  1 
ATOM 2060 C CG  . ASP B 2 153 ? 197.601 224.992 349.766 1.00 82.62  ? 153 ASP B CG  1 
ATOM 2061 O OD1 . ASP B 2 153 ? 198.542 224.700 350.531 1.00 85.21  ? 153 ASP B OD1 1 
ATOM 2062 O OD2 . ASP B 2 153 ? 196.404 224.965 350.122 1.00 79.17  ? 153 ASP B OD2 1 
ATOM 2063 N N   . ALA B 2 154 ? 196.314 222.844 347.120 1.00 73.41  ? 154 ALA B N   1 
ATOM 2064 C CA  . ALA B 2 154 ? 195.462 221.689 347.376 1.00 67.88  ? 154 ALA B CA  1 
ATOM 2065 C C   . ALA B 2 154 ? 196.206 220.392 347.096 1.00 70.51  ? 154 ALA B C   1 
ATOM 2066 O O   . ALA B 2 154 ? 196.093 219.424 347.856 1.00 68.84  ? 154 ALA B O   1 
ATOM 2067 C CB  . ALA B 2 154 ? 194.194 221.770 346.528 1.00 66.53  ? 154 ALA B CB  1 
ATOM 2068 N N   . LEU B 2 155 ? 196.974 220.355 346.013 1.00 71.40  ? 155 LEU B N   1 
ATOM 2069 C CA  . LEU B 2 155 ? 197.715 219.159 345.622 1.00 69.72  ? 155 LEU B CA  1 
ATOM 2070 C C   . LEU B 2 155 ? 199.122 219.158 346.209 1.00 69.55  ? 155 LEU B C   1 
ATOM 2071 O O   . LEU B 2 155 ? 200.097 218.882 345.514 1.00 69.43  ? 155 LEU B O   1 
ATOM 2072 C CB  . LEU B 2 155 ? 197.766 219.062 344.103 1.00 64.39  ? 155 LEU B CB  1 
ATOM 2073 C CG  . LEU B 2 155 ? 196.452 219.264 343.354 1.00 64.75  ? 155 LEU B CG  1 
ATOM 2074 C CD1 . LEU B 2 155 ? 196.707 219.222 341.864 1.00 67.44  ? 155 LEU B CD1 1 
ATOM 2075 C CD2 . LEU B 2 155 ? 195.436 218.213 343.745 1.00 70.92  ? 155 LEU B CD2 1 
ATOM 2076 N N   . ARG B 2 156 ? 199.246 219.461 347.499 1.00 74.55  ? 156 ARG B N   1 
ATOM 2077 C CA  . ARG B 2 156 ? 200.548 219.463 348.149 1.00 77.93  ? 156 ARG B CA  1 
ATOM 2078 C C   . ARG B 2 156 ? 200.890 218.126 348.786 1.00 80.84  ? 156 ARG B C   1 
ATOM 2079 O O   . ARG B 2 156 ? 202.014 217.958 349.268 1.00 83.19  ? 156 ARG B O   1 
ATOM 2080 C CB  . ARG B 2 156 ? 200.621 220.568 349.212 1.00 76.95  ? 156 ARG B CB  1 
ATOM 2081 C CG  . ARG B 2 156 ? 199.746 220.347 350.440 1.00 83.17  ? 156 ARG B CG  1 
ATOM 2082 C CD  . ARG B 2 156 ? 200.483 220.752 351.708 1.00 81.36  ? 156 ARG B CD  1 
ATOM 2083 N NE  . ARG B 2 156 ? 200.794 222.177 351.738 1.00 80.90  ? 156 ARG B NE  1 
ATOM 2084 C CZ  . ARG B 2 156 ? 200.092 223.094 352.391 1.00 84.31  ? 156 ARG B CZ  1 
ATOM 2085 N NH1 . ARG B 2 156 ? 199.018 222.776 353.096 1.00 81.88  ? 156 ARG B NH1 1 
ATOM 2086 N NH2 . ARG B 2 156 ? 200.478 224.365 352.338 1.00 82.65  ? 156 ARG B NH2 1 
ATOM 2087 N N   . ASP B 2 157 ? 199.953 217.178 348.805 1.00 78.16  ? 157 ASP B N   1 
ATOM 2088 C CA  . ASP B 2 157 ? 200.210 215.838 349.315 1.00 79.71  ? 157 ASP B CA  1 
ATOM 2089 C C   . ASP B 2 157 ? 199.812 214.760 348.316 1.00 74.53  ? 157 ASP B C   1 
ATOM 2090 O O   . ASP B 2 157 ? 199.729 213.586 348.692 1.00 72.87  ? 157 ASP B O   1 
ATOM 2091 C CB  . ASP B 2 157 ? 199.466 215.610 350.636 1.00 80.20  ? 157 ASP B CB  1 
ATOM 2092 C CG  . ASP B 2 157 ? 199.997 216.471 351.761 1.00 82.56  ? 157 ASP B CG  1 
ATOM 2093 O OD1 . ASP B 2 157 ? 200.903 217.291 351.508 1.00 81.84  ? 157 ASP B OD1 1 
ATOM 2094 O OD2 . ASP B 2 157 ? 199.510 216.325 352.902 1.00 80.10  ? 157 ASP B OD2 1 
ATOM 2095 N N   . MET B 2 158 ? 199.569 215.122 347.060 1.00 69.28  ? 158 MET B N   1 
ATOM 2096 C CA  . MET B 2 158 ? 199.050 214.181 346.071 1.00 69.45  ? 158 MET B CA  1 
ATOM 2097 C C   . MET B 2 158 ? 200.192 213.466 345.347 1.00 72.40  ? 158 MET B C   1 
ATOM 2098 O O   . MET B 2 158 ? 200.337 213.522 344.127 1.00 69.00  ? 158 MET B O   1 
ATOM 2099 C CB  . MET B 2 158 ? 198.137 214.906 345.091 1.00 72.33  ? 158 MET B CB  1 
ATOM 2100 C CG  . MET B 2 158 ? 196.866 215.445 345.726 1.00 72.41  ? 158 MET B CG  1 
ATOM 2101 S SD  . MET B 2 158 ? 195.774 214.150 346.336 1.00 66.43  ? 158 MET B SD  1 
ATOM 2102 C CE  . MET B 2 158 ? 194.783 215.076 347.499 1.00 70.68  ? 158 MET B CE  1 
ATOM 2103 N N   . GLY B 2 159 ? 201.006 212.781 346.137 1.00 78.10  ? 159 GLY B N   1 
ATOM 2104 C CA  . GLY B 2 159 ? 201.989 211.872 345.572 1.00 73.45  ? 159 GLY B CA  1 
ATOM 2105 C C   . GLY B 2 159 ? 202.959 212.576 344.647 1.00 78.05  ? 159 GLY B C   1 
ATOM 2106 O O   . GLY B 2 159 ? 203.664 213.512 345.040 1.00 83.96  ? 159 GLY B O   1 
ATOM 2107 N N   . LEU B 2 160 ? 203.001 212.122 343.393 1.00 83.21  ? 160 LEU B N   1 
ATOM 2108 C CA  . LEU B 2 160 ? 204.055 212.561 342.484 1.00 85.32  ? 160 LEU B CA  1 
ATOM 2109 C C   . LEU B 2 160 ? 203.996 214.062 342.237 1.00 86.34  ? 160 LEU B C   1 
ATOM 2110 O O   . LEU B 2 160 ? 205.036 214.728 342.193 1.00 89.03  ? 160 LEU B O   1 
ATOM 2111 C CB  . LEU B 2 160 ? 203.962 211.793 341.167 1.00 84.96  ? 160 LEU B CB  1 
ATOM 2112 C CG  . LEU B 2 160 ? 204.371 210.320 341.249 1.00 89.42  ? 160 LEU B CG  1 
ATOM 2113 C CD1 . LEU B 2 160 ? 204.207 209.632 339.901 1.00 88.02  ? 160 LEU B CD1 1 
ATOM 2114 C CD2 . LEU B 2 160 ? 205.801 210.179 341.748 1.00 86.93  ? 160 LEU B CD2 1 
ATOM 2115 N N   . PHE B 2 161 ? 202.798 214.620 342.064 1.00 72.80  ? 161 PHE B N   1 
ATOM 2116 C CA  . PHE B 2 161 ? 202.703 216.066 341.896 1.00 70.48  ? 161 PHE B CA  1 
ATOM 2117 C C   . PHE B 2 161 ? 203.165 216.791 343.151 1.00 72.99  ? 161 PHE B C   1 
ATOM 2118 O O   . PHE B 2 161 ? 203.884 217.793 343.070 1.00 81.94  ? 161 PHE B O   1 
ATOM 2119 C CB  . PHE B 2 161 ? 201.275 216.471 341.545 1.00 76.22  ? 161 PHE B CB  1 
ATOM 2120 C CG  . PHE B 2 161 ? 201.133 217.924 341.207 1.00 72.70  ? 161 PHE B CG  1 
ATOM 2121 C CD1 . PHE B 2 161 ? 201.463 218.388 339.947 1.00 71.91  ? 161 PHE B CD1 1 
ATOM 2122 C CD2 . PHE B 2 161 ? 200.682 218.827 342.149 1.00 71.74  ? 161 PHE B CD2 1 
ATOM 2123 C CE1 . PHE B 2 161 ? 201.340 219.721 339.635 1.00 72.14  ? 161 PHE B CE1 1 
ATOM 2124 C CE2 . PHE B 2 161 ? 200.558 220.163 341.839 1.00 74.73  ? 161 PHE B CE2 1 
ATOM 2125 C CZ  . PHE B 2 161 ? 200.888 220.609 340.581 1.00 73.58  ? 161 PHE B CZ  1 
ATOM 2126 N N   . GLY B 2 162 ? 202.765 216.300 344.323 1.00 73.36  ? 162 GLY B N   1 
ATOM 2127 C CA  . GLY B 2 162 ? 203.193 216.926 345.561 1.00 71.36  ? 162 GLY B CA  1 
ATOM 2128 C C   . GLY B 2 162 ? 204.686 216.830 345.789 1.00 69.95  ? 162 GLY B C   1 
ATOM 2129 O O   . GLY B 2 162 ? 205.293 217.748 346.345 1.00 73.47  ? 162 GLY B O   1 
ATOM 2130 N N   . GLN B 2 163 ? 205.298 215.723 345.375 1.00 75.56  ? 163 GLN B N   1 
ATOM 2131 C CA  . GLN B 2 163 ? 206.735 215.530 345.511 1.00 79.17  ? 163 GLN B CA  1 
ATOM 2132 C C   . GLN B 2 163 ? 207.522 216.117 344.349 1.00 80.00  ? 163 GLN B C   1 
ATOM 2133 O O   . GLN B 2 163 ? 208.756 216.071 344.371 1.00 83.58  ? 163 GLN B O   1 
ATOM 2134 C CB  . GLN B 2 163 ? 207.058 214.039 345.643 1.00 78.22  ? 163 GLN B CB  1 
ATOM 2135 C CG  . GLN B 2 163 ? 206.487 213.393 346.893 1.00 81.77  ? 163 GLN B CG  1 
ATOM 2136 C CD  . GLN B 2 163 ? 207.025 214.011 348.168 1.00 81.37  ? 163 GLN B CD  1 
ATOM 2137 O OE1 . GLN B 2 163 ? 208.020 214.734 348.150 1.00 78.59  ? 163 GLN B OE1 1 
ATOM 2138 N NE2 . GLN B 2 163 ? 206.365 213.731 349.285 1.00 77.80  ? 163 GLN B NE2 1 
ATOM 2139 N N   . ASN B 2 164 ? 206.845 216.650 343.335 1.00 76.04  ? 164 ASN B N   1 
ATOM 2140 C CA  . ASN B 2 164 ? 207.505 217.363 342.251 1.00 71.75  ? 164 ASN B CA  1 
ATOM 2141 C C   . ASN B 2 164 ? 207.421 218.870 342.402 1.00 67.08  ? 164 ASN B C   1 
ATOM 2142 O O   . ASN B 2 164 ? 208.371 219.568 342.038 1.00 77.13  ? 164 ASN B O   1 
ATOM 2143 C CB  . ASN B 2 164 ? 206.898 216.966 340.903 1.00 75.00  ? 164 ASN B CB  1 
ATOM 2144 C CG  . ASN B 2 164 ? 207.370 215.608 340.433 1.00 82.10  ? 164 ASN B CG  1 
ATOM 2145 O OD1 . ASN B 2 164 ? 207.806 214.781 341.232 1.00 82.08  ? 164 ASN B OD1 1 
ATOM 2146 N ND2 . ASN B 2 164 ? 207.292 215.373 339.128 1.00 79.73  ? 164 ASN B ND2 1 
ATOM 2147 N N   . MET B 2 165 ? 206.313 219.392 342.924 1.00 67.26  ? 165 MET B N   1 
ATOM 2148 C CA  . MET B 2 165 ? 206.224 220.822 343.180 1.00 72.11  ? 165 MET B CA  1 
ATOM 2149 C C   . MET B 2 165 ? 207.020 221.235 344.407 1.00 72.81  ? 165 MET B C   1 
ATOM 2150 O O   . MET B 2 165 ? 207.408 222.402 344.513 1.00 76.16  ? 165 MET B O   1 
ATOM 2151 C CB  . MET B 2 165 ? 204.765 221.247 343.353 1.00 73.29  ? 165 MET B CB  1 
ATOM 2152 C CG  . MET B 2 165 ? 204.075 220.656 344.567 1.00 74.54  ? 165 MET B CG  1 
ATOM 2153 S SD  . MET B 2 165 ? 202.409 221.299 344.800 1.00 83.11  ? 165 MET B SD  1 
ATOM 2154 C CE  . MET B 2 165 ? 202.764 222.940 345.415 1.00 73.35  ? 165 MET B CE  1 
ATOM 2155 N N   . TYR B 2 166 ? 207.275 220.309 345.329 1.00 75.00  ? 166 TYR B N   1 
ATOM 2156 C CA  . TYR B 2 166 ? 208.018 220.628 346.540 1.00 74.08  ? 166 TYR B CA  1 
ATOM 2157 C C   . TYR B 2 166 ? 209.514 220.400 346.387 1.00 78.16  ? 166 TYR B C   1 
ATOM 2158 O O   . TYR B 2 166 ? 210.305 221.087 347.043 1.00 77.40  ? 166 TYR B O   1 
ATOM 2159 C CB  . TYR B 2 166 ? 207.489 219.796 347.710 1.00 74.10  ? 166 TYR B CB  1 
ATOM 2160 C CG  . TYR B 2 166 ? 208.138 220.117 349.034 1.00 78.04  ? 166 TYR B CG  1 
ATOM 2161 C CD1 . TYR B 2 166 ? 207.655 221.140 349.836 1.00 76.62  ? 166 TYR B CD1 1 
ATOM 2162 C CD2 . TYR B 2 166 ? 209.229 219.392 349.486 1.00 82.30  ? 166 TYR B CD2 1 
ATOM 2163 C CE1 . TYR B 2 166 ? 208.246 221.434 351.048 1.00 82.76  ? 166 TYR B CE1 1 
ATOM 2164 C CE2 . TYR B 2 166 ? 209.826 219.677 350.696 1.00 79.49  ? 166 TYR B CE2 1 
ATOM 2165 C CZ  . TYR B 2 166 ? 209.331 220.698 351.473 1.00 81.66  ? 166 TYR B CZ  1 
ATOM 2166 O OH  . TYR B 2 166 ? 209.924 220.985 352.680 1.00 79.75  ? 166 TYR B OH  1 
ATOM 2167 N N   . TYR B 2 167 ? 209.923 219.459 345.538 1.00 80.29  ? 167 TYR B N   1 
ATOM 2168 C CA  . TYR B 2 167 ? 211.333 219.216 345.242 1.00 74.76  ? 167 TYR B CA  1 
ATOM 2169 C C   . TYR B 2 167 ? 211.731 219.803 343.898 1.00 73.71  ? 167 TYR B C   1 
ATOM 2170 O O   . TYR B 2 167 ? 212.479 219.189 343.134 1.00 73.92  ? 167 TYR B O   1 
ATOM 2171 C CB  . TYR B 2 167 ? 211.644 217.722 345.285 1.00 74.47  ? 167 TYR B CB  1 
ATOM 2172 C CG  . TYR B 2 167 ? 211.651 217.112 346.673 1.00 80.52  ? 167 TYR B CG  1 
ATOM 2173 C CD1 . TYR B 2 167 ? 211.781 217.901 347.809 1.00 76.77  ? 167 TYR B CD1 1 
ATOM 2174 C CD2 . TYR B 2 167 ? 211.538 215.740 346.845 1.00 82.89  ? 167 TYR B CD2 1 
ATOM 2175 C CE1 . TYR B 2 167 ? 211.790 217.343 349.069 1.00 76.41  ? 167 TYR B CE1 1 
ATOM 2176 C CE2 . TYR B 2 167 ? 211.546 215.174 348.104 1.00 81.65  ? 167 TYR B CE2 1 
ATOM 2177 C CZ  . TYR B 2 167 ? 211.672 215.982 349.211 1.00 82.22  ? 167 TYR B CZ  1 
ATOM 2178 O OH  . TYR B 2 167 ? 211.682 215.428 350.469 1.00 83.69  ? 167 TYR B OH  1 
ATOM 2179 N N   . HIS B 2 168 ? 211.218 220.988 343.579 1.00 73.25  ? 168 HIS B N   1 
ATOM 2180 C CA  . HIS B 2 168 ? 211.687 221.775 342.451 1.00 72.76  ? 168 HIS B CA  1 
ATOM 2181 C C   . HIS B 2 168 ? 211.729 223.233 342.883 1.00 72.23  ? 168 HIS B C   1 
ATOM 2182 O O   . HIS B 2 168 ? 211.420 223.569 344.030 1.00 73.21  ? 168 HIS B O   1 
ATOM 2183 C CB  . HIS B 2 168 ? 210.800 221.578 341.218 1.00 65.01  ? 168 HIS B CB  1 
ATOM 2184 C CG  . HIS B 2 168 ? 211.035 220.283 340.506 1.00 68.91  ? 168 HIS B CG  1 
ATOM 2185 N ND1 . HIS B 2 168 ? 210.727 219.061 341.062 1.00 75.96  ? 168 HIS B ND1 1 
ATOM 2186 C CD2 . HIS B 2 168 ? 211.545 220.020 339.280 1.00 70.93  ? 168 HIS B CD2 1 
ATOM 2187 C CE1 . HIS B 2 168 ? 211.037 218.102 340.209 1.00 73.17  ? 168 HIS B CE1 1 
ATOM 2188 N NE2 . HIS B 2 168 ? 211.535 218.657 339.120 1.00 71.19  ? 168 HIS B NE2 1 
ATOM 2189 N N   . TYR B 2 169 ? 212.117 224.103 341.962 1.00 65.46  ? 169 TYR B N   1 
ATOM 2190 C CA  . TYR B 2 169 ? 212.188 225.534 342.225 1.00 67.26  ? 169 TYR B CA  1 
ATOM 2191 C C   . TYR B 2 169 ? 211.219 226.339 341.379 1.00 63.93  ? 169 TYR B C   1 
ATOM 2192 O O   . TYR B 2 169 ? 210.544 227.226 341.904 1.00 62.94  ? 169 TYR B O   1 
ATOM 2193 C CB  . TYR B 2 169 ? 213.618 226.041 341.991 1.00 70.81  ? 169 TYR B CB  1 
ATOM 2194 C CG  . TYR B 2 169 ? 213.769 227.536 342.141 1.00 65.82  ? 169 TYR B CG  1 
ATOM 2195 C CD1 . TYR B 2 169 ? 213.489 228.165 343.344 1.00 70.27  ? 169 TYR B CD1 1 
ATOM 2196 C CD2 . TYR B 2 169 ? 214.200 228.318 341.081 1.00 61.57  ? 169 TYR B CD2 1 
ATOM 2197 C CE1 . TYR B 2 169 ? 213.628 229.530 343.483 1.00 70.49  ? 169 TYR B CE1 1 
ATOM 2198 C CE2 . TYR B 2 169 ? 214.342 229.681 341.211 1.00 65.33  ? 169 TYR B CE2 1 
ATOM 2199 C CZ  . TYR B 2 169 ? 214.056 230.282 342.412 1.00 66.41  ? 169 TYR B CZ  1 
ATOM 2200 O OH  . TYR B 2 169 ? 214.197 231.642 342.541 1.00 64.54  ? 169 TYR B OH  1 
ATOM 2201 N N   . LEU B 2 170 ? 211.125 226.051 340.086 1.00 64.02  ? 170 LEU B N   1 
ATOM 2202 C CA  . LEU B 2 170 ? 210.174 226.710 339.205 1.00 63.75  ? 170 LEU B CA  1 
ATOM 2203 C C   . LEU B 2 170 ? 209.136 225.699 338.743 1.00 66.51  ? 170 LEU B C   1 
ATOM 2204 O O   . LEU B 2 170 ? 209.472 224.554 338.438 1.00 64.31  ? 170 LEU B O   1 
ATOM 2205 C CB  . LEU B 2 170 ? 210.879 227.325 337.996 1.00 67.53  ? 170 LEU B CB  1 
ATOM 2206 C CG  . LEU B 2 170 ? 212.017 228.290 338.317 1.00 69.19  ? 170 LEU B CG  1 
ATOM 2207 C CD1 . LEU B 2 170 ? 212.599 228.862 337.042 1.00 70.86  ? 170 LEU B CD1 1 
ATOM 2208 C CD2 . LEU B 2 170 ? 211.535 229.402 339.228 1.00 75.32  ? 170 LEU B CD2 1 
ATOM 2209 N N   . GLY B 2 171 ? 207.878 226.119 338.694 1.00 74.85  ? 171 GLY B N   1 
ATOM 2210 C CA  . GLY B 2 171 ? 206.828 225.222 338.260 1.00 73.03  ? 171 GLY B CA  1 
ATOM 2211 C C   . GLY B 2 171 ? 205.597 225.934 337.745 1.00 70.67  ? 171 GLY B C   1 
ATOM 2212 O O   . GLY B 2 171 ? 205.081 226.845 338.397 1.00 73.44  ? 171 GLY B O   1 
ATOM 2213 N N   . ARG B 2 172 ? 205.114 225.529 336.575 1.00 62.12  ? 172 ARG B N   1 
ATOM 2214 C CA  . ARG B 2 172 ? 203.891 226.081 336.013 1.00 59.63  ? 172 ARG B CA  1 
ATOM 2215 C C   . ARG B 2 172 ? 203.002 224.947 335.538 1.00 63.90  ? 172 ARG B C   1 
ATOM 2216 O O   . ARG B 2 172 ? 203.495 223.931 335.047 1.00 70.39  ? 172 ARG B O   1 
ATOM 2217 C CB  . ARG B 2 172 ? 204.180 227.030 334.850 1.00 65.36  ? 172 ARG B CB  1 
ATOM 2218 C CG  . ARG B 2 172 ? 204.754 226.360 333.620 1.00 68.29  ? 172 ARG B CG  1 
ATOM 2219 C CD  . ARG B 2 172 ? 204.857 227.339 332.471 1.00 70.32  ? 172 ARG B CD  1 
ATOM 2220 N NE  . ARG B 2 172 ? 203.547 227.776 332.007 1.00 67.78  ? 172 ARG B NE  1 
ATOM 2221 C CZ  . ARG B 2 172 ? 203.348 228.736 331.116 1.00 64.92  ? 172 ARG B CZ  1 
ATOM 2222 N NH1 . ARG B 2 172 ? 204.355 229.404 330.580 1.00 67.06  ? 172 ARG B NH1 1 
ATOM 2223 N NH2 . ARG B 2 172 ? 202.106 229.036 330.752 1.00 64.90  ? 172 ARG B NH2 1 
ATOM 2224 N N   . SER B 2 173 ? 201.693 225.121 335.682 1.00 68.00  ? 173 SER B N   1 
ATOM 2225 C CA  . SER B 2 173 ? 200.763 224.092 335.247 1.00 70.70  ? 173 SER B CA  1 
ATOM 2226 C C   . SER B 2 173 ? 199.354 224.654 335.270 1.00 59.54  ? 173 SER B C   1 
ATOM 2227 O O   . SER B 2 173 ? 198.973 225.339 336.221 1.00 61.16  ? 173 SER B O   1 
ATOM 2228 C CB  . SER B 2 173 ? 200.846 222.853 336.148 1.00 73.49  ? 173 SER B CB  1 
ATOM 2229 O OG  . SER B 2 173 ? 200.416 223.156 337.462 1.00 71.94  ? 173 SER B OG  1 
ATOM 2230 N N   . GLY B 2 174 ? 198.591 224.358 334.224 1.00 56.51  ? 174 GLY B N   1 
ATOM 2231 C CA  . GLY B 2 174 ? 197.180 224.669 334.223 1.00 59.49  ? 174 GLY B CA  1 
ATOM 2232 C C   . GLY B 2 174 ? 196.437 223.649 335.056 1.00 59.32  ? 174 GLY B C   1 
ATOM 2233 O O   . GLY B 2 174 ? 197.057 222.902 335.813 1.00 61.58  ? 174 GLY B O   1 
ATOM 2234 N N   . TYR B 2 175 ? 195.114 223.604 334.936 1.00 50.48  ? 175 TYR B N   1 
ATOM 2235 C CA  . TYR B 2 175 ? 194.330 222.601 335.637 1.00 44.21  ? 175 TYR B CA  1 
ATOM 2236 C C   . TYR B 2 175 ? 193.084 222.299 334.826 1.00 52.65  ? 175 TYR B C   1 
ATOM 2237 O O   . TYR B 2 175 ? 192.795 222.949 333.820 1.00 65.06  ? 175 TYR B O   1 
ATOM 2238 C CB  . TYR B 2 175 ? 193.943 223.060 337.042 1.00 51.34  ? 175 TYR B CB  1 
ATOM 2239 C CG  . TYR B 2 175 ? 195.110 223.458 337.905 1.00 47.44  ? 175 TYR B CG  1 
ATOM 2240 C CD1 . TYR B 2 175 ? 195.791 222.519 338.658 1.00 50.58  ? 175 TYR B CD1 1 
ATOM 2241 C CD2 . TYR B 2 175 ? 195.525 224.775 337.970 1.00 51.19  ? 175 TYR B CD2 1 
ATOM 2242 C CE1 . TYR B 2 175 ? 196.855 222.882 339.450 1.00 56.90  ? 175 TYR B CE1 1 
ATOM 2243 C CE2 . TYR B 2 175 ? 196.586 225.149 338.757 1.00 56.98  ? 175 TYR B CE2 1 
ATOM 2244 C CZ  . TYR B 2 175 ? 197.249 224.199 339.495 1.00 66.52  ? 175 TYR B CZ  1 
ATOM 2245 O OH  . TYR B 2 175 ? 198.310 224.575 340.282 1.00 68.60  ? 175 TYR B OH  1 
ATOM 2246 N N   . THR B 2 176 ? 192.355 221.283 335.269 1.00 47.13  ? 176 THR B N   1 
ATOM 2247 C CA  . THR B 2 176 ? 191.069 220.920 334.691 1.00 46.12  ? 176 THR B CA  1 
ATOM 2248 C C   . THR B 2 176 ? 190.086 220.623 335.815 1.00 49.39  ? 176 THR B C   1 
ATOM 2249 O O   . THR B 2 176 ? 189.434 219.580 335.843 1.00 63.42  ? 176 THR B O   1 
ATOM 2250 C CB  . THR B 2 176 ? 191.207 219.734 333.744 1.00 52.12  ? 176 THR B CB  1 
ATOM 2251 O OG1 . THR B 2 176 ? 192.248 220.000 332.798 1.00 65.51  ? 176 THR B OG1 1 
ATOM 2252 C CG2 . THR B 2 176 ? 189.913 219.491 332.996 1.00 54.74  ? 176 THR B CG2 1 
ATOM 2253 N N   . VAL B 2 177 ? 190.001 221.542 336.779 1.00 46.43  ? 177 VAL B N   1 
ATOM 2254 C CA  . VAL B 2 177 ? 189.130 221.338 337.928 1.00 46.16  ? 177 VAL B CA  1 
ATOM 2255 C C   . VAL B 2 177 ? 187.769 220.866 337.452 1.00 49.53  ? 177 VAL B C   1 
ATOM 2256 O O   . VAL B 2 177 ? 187.246 221.334 336.436 1.00 61.32  ? 177 VAL B O   1 
ATOM 2257 C CB  . VAL B 2 177 ? 189.011 222.630 338.755 1.00 46.83  ? 177 VAL B CB  1 
ATOM 2258 C CG1 . VAL B 2 177 ? 188.112 222.406 339.953 1.00 49.00  ? 177 VAL B CG1 1 
ATOM 2259 C CG2 . VAL B 2 177 ? 190.381 223.102 339.198 1.00 58.04  ? 177 VAL B CG2 1 
ATOM 2260 N N   . HIS B 2 178 ? 187.196 219.918 338.186 1.00 51.52  ? 178 HIS B N   1 
ATOM 2261 C CA  . HIS B 2 178 ? 185.965 219.258 337.767 1.00 51.77  ? 178 HIS B CA  1 
ATOM 2262 C C   . HIS B 2 178 ? 185.158 218.960 339.019 1.00 60.65  ? 178 HIS B C   1 
ATOM 2263 O O   . HIS B 2 178 ? 185.546 218.101 339.814 1.00 72.44  ? 178 HIS B O   1 
ATOM 2264 C CB  . HIS B 2 178 ? 186.281 217.983 336.992 1.00 49.83  ? 178 HIS B CB  1 
ATOM 2265 C CG  . HIS B 2 178 ? 185.075 217.272 336.468 1.00 57.89  ? 178 HIS B CG  1 
ATOM 2266 N ND1 . HIS B 2 178 ? 185.022 216.747 335.195 1.00 60.50  ? 178 HIS B ND1 1 
ATOM 2267 C CD2 . HIS B 2 178 ? 183.885 216.983 337.044 1.00 59.61  ? 178 HIS B CD2 1 
ATOM 2268 C CE1 . HIS B 2 178 ? 183.847 216.176 335.006 1.00 65.97  ? 178 HIS B CE1 1 
ATOM 2269 N NE2 . HIS B 2 178 ? 183.139 216.303 336.113 1.00 67.77  ? 178 HIS B NE2 1 
ATOM 2270 N N   . VAL B 2 179 ? 184.044 219.662 339.192 1.00 47.50  ? 179 VAL B N   1 
ATOM 2271 C CA  . VAL B 2 179 ? 183.183 219.497 340.356 1.00 47.64  ? 179 VAL B CA  1 
ATOM 2272 C C   . VAL B 2 179 ? 181.985 218.656 339.957 1.00 50.41  ? 179 VAL B C   1 
ATOM 2273 O O   . VAL B 2 179 ? 181.383 218.878 338.901 1.00 59.55  ? 179 VAL B O   1 
ATOM 2274 C CB  . VAL B 2 179 ? 182.728 220.858 340.910 1.00 46.29  ? 179 VAL B CB  1 
ATOM 2275 C CG1 . VAL B 2 179 ? 181.980 220.670 342.210 1.00 53.37  ? 179 VAL B CG1 1 
ATOM 2276 C CG2 . VAL B 2 179 ? 183.916 221.772 341.100 1.00 50.29  ? 179 VAL B CG2 1 
ATOM 2277 N N   . GLN B 2 180 ? 181.643 217.678 340.791 1.00 54.23  ? 180 GLN B N   1 
ATOM 2278 C CA  . GLN B 2 180 ? 180.450 216.868 340.584 1.00 55.46  ? 180 GLN B CA  1 
ATOM 2279 C C   . GLN B 2 180 ? 179.652 216.821 341.875 1.00 60.28  ? 180 GLN B C   1 
ATOM 2280 O O   . GLN B 2 180 ? 180.200 216.503 342.934 1.00 65.86  ? 180 GLN B O   1 
ATOM 2281 C CB  . GLN B 2 180 ? 180.807 215.453 340.136 1.00 55.23  ? 180 GLN B CB  1 
ATOM 2282 C CG  . GLN B 2 180 ? 181.639 215.404 338.874 1.00 59.36  ? 180 GLN B CG  1 
ATOM 2283 C CD  . GLN B 2 180 ? 181.634 214.034 338.233 1.00 65.76  ? 180 GLN B CD  1 
ATOM 2284 O OE1 . GLN B 2 180 ? 180.682 213.271 338.385 1.00 68.93  ? 180 GLN B OE1 1 
ATOM 2285 N NE2 . GLN B 2 180 ? 182.701 213.713 337.513 1.00 62.26  ? 180 GLN B NE2 1 
ATOM 2286 N N   . CYS B 2 181 ? 178.362 217.127 341.782 1.00 54.39  ? 181 CYS B N   1 
ATOM 2287 C CA  . CYS B 2 181 ? 177.457 217.136 342.929 1.00 45.30  ? 181 CYS B CA  1 
ATOM 2288 C C   . CYS B 2 181 ? 176.400 216.064 342.699 1.00 53.30  ? 181 CYS B C   1 
ATOM 2289 O O   . CYS B 2 181 ? 175.380 216.318 342.052 1.00 64.12  ? 181 CYS B O   1 
ATOM 2290 C CB  . CYS B 2 181 ? 176.825 218.508 343.112 1.00 56.51  ? 181 CYS B CB  1 
ATOM 2291 S SG  . CYS B 2 181 ? 175.803 218.650 344.587 1.00 86.32  ? 181 CYS B SG  1 
ATOM 2292 N N   . ASN B 2 182 ? 176.638 214.871 343.236 1.00 60.18  ? 182 ASN B N   1 
ATOM 2293 C CA  . ASN B 2 182 ? 175.748 213.737 343.012 1.00 60.78  ? 182 ASN B CA  1 
ATOM 2294 C C   . ASN B 2 182 ? 174.458 213.939 343.793 1.00 63.13  ? 182 ASN B C   1 
ATOM 2295 O O   . ASN B 2 182 ? 174.436 213.794 345.019 1.00 62.24  ? 182 ASN B O   1 
ATOM 2296 C CB  . ASN B 2 182 ? 176.439 212.445 343.430 1.00 60.44  ? 182 ASN B CB  1 
ATOM 2297 C CG  . ASN B 2 182 ? 177.817 212.303 342.826 1.00 64.46  ? 182 ASN B CG  1 
ATOM 2298 O OD1 . ASN B 2 182 ? 178.806 212.135 343.539 1.00 63.91  ? 182 ASN B OD1 1 
ATOM 2299 N ND2 . ASN B 2 182 ? 177.893 212.378 341.503 1.00 65.83  ? 182 ASN B ND2 1 
ATOM 2300 N N   . ALA B 2 183 ? 173.379 214.267 343.087 1.00 57.09  ? 183 ALA B N   1 
ATOM 2301 C CA  . ALA B 2 183 ? 172.089 214.515 343.710 1.00 54.40  ? 183 ALA B CA  1 
ATOM 2302 C C   . ALA B 2 183 ? 171.000 213.845 342.891 1.00 53.04  ? 183 ALA B C   1 
ATOM 2303 O O   . ALA B 2 183 ? 171.151 213.614 341.689 1.00 55.34  ? 183 ALA B O   1 
ATOM 2304 C CB  . ALA B 2 183 ? 171.799 216.013 343.835 1.00 53.06  ? 183 ALA B CB  1 
ATOM 2305 N N   . SER B 2 184 ? 169.892 213.541 343.559 1.00 51.38  ? 184 SER B N   1 
ATOM 2306 C CA  . SER B 2 184 ? 168.759 212.882 342.930 1.00 51.79  ? 184 SER B CA  1 
ATOM 2307 C C   . SER B 2 184 ? 167.843 213.928 342.300 1.00 54.16  ? 184 SER B C   1 
ATOM 2308 O O   . SER B 2 184 ? 168.162 215.118 342.252 1.00 57.37  ? 184 SER B O   1 
ATOM 2309 C CB  . SER B 2 184 ? 168.023 212.025 343.954 1.00 49.09  ? 184 SER B CB  1 
ATOM 2310 O OG  . SER B 2 184 ? 167.682 212.795 345.091 1.00 54.75  ? 184 SER B OG  1 
ATOM 2311 N N   . LYS B 2 185 ? 166.686 213.492 341.804 1.00 53.65  ? 185 LYS B N   1 
ATOM 2312 C CA  . LYS B 2 185 ? 165.746 214.409 341.176 1.00 52.87  ? 185 LYS B CA  1 
ATOM 2313 C C   . LYS B 2 185 ? 164.971 215.237 342.188 1.00 51.59  ? 185 LYS B C   1 
ATOM 2314 O O   . LYS B 2 185 ? 164.379 216.253 341.811 1.00 52.17  ? 185 LYS B O   1 
ATOM 2315 C CB  . LYS B 2 185 ? 164.753 213.639 340.304 1.00 53.71  ? 185 LYS B CB  1 
ATOM 2316 C CG  . LYS B 2 185 ? 165.375 212.565 339.431 1.00 56.95  ? 185 LYS B CG  1 
ATOM 2317 C CD  . LYS B 2 185 ? 166.410 213.136 338.482 1.00 56.32  ? 185 LYS B CD  1 
ATOM 2318 C CE  . LYS B 2 185 ? 167.012 212.047 337.611 1.00 57.82  ? 185 LYS B CE  1 
ATOM 2319 N NZ  . LYS B 2 185 ? 167.657 210.975 338.421 1.00 52.24  ? 185 LYS B NZ  1 
ATOM 2320 N N   . PHE B 2 186 ? 164.961 214.833 343.455 1.00 46.76  ? 186 PHE B N   1 
ATOM 2321 C CA  . PHE B 2 186 ? 164.168 215.493 344.480 1.00 46.88  ? 186 PHE B CA  1 
ATOM 2322 C C   . PHE B 2 186 ? 164.981 216.470 345.317 1.00 54.97  ? 186 PHE B C   1 
ATOM 2323 O O   . PHE B 2 186 ? 164.476 216.972 346.324 1.00 58.47  ? 186 PHE B O   1 
ATOM 2324 C CB  . PHE B 2 186 ? 163.511 214.446 345.374 1.00 48.86  ? 186 PHE B CB  1 
ATOM 2325 C CG  . PHE B 2 186 ? 162.503 213.600 344.656 1.00 53.54  ? 186 PHE B CG  1 
ATOM 2326 C CD1 . PHE B 2 186 ? 162.900 212.491 343.934 1.00 49.14  ? 186 PHE B CD1 1 
ATOM 2327 C CD2 . PHE B 2 186 ? 161.158 213.924 344.689 1.00 51.51  ? 186 PHE B CD2 1 
ATOM 2328 C CE1 . PHE B 2 186 ? 161.979 211.718 343.269 1.00 49.69  ? 186 PHE B CE1 1 
ATOM 2329 C CE2 . PHE B 2 186 ? 160.234 213.154 344.022 1.00 48.53  ? 186 PHE B CE2 1 
ATOM 2330 C CZ  . PHE B 2 186 ? 160.645 212.049 343.312 1.00 48.78  ? 186 PHE B CZ  1 
ATOM 2331 N N   . HIS B 2 187 ? 166.220 216.748 344.926 1.00 57.79  ? 187 HIS B N   1 
ATOM 2332 C CA  . HIS B 2 187 ? 167.030 217.783 345.549 1.00 50.21  ? 187 HIS B CA  1 
ATOM 2333 C C   . HIS B 2 187 ? 167.053 219.013 344.653 1.00 50.19  ? 187 HIS B C   1 
ATOM 2334 O O   . HIS B 2 187 ? 167.168 218.899 343.430 1.00 49.23  ? 187 HIS B O   1 
ATOM 2335 C CB  . HIS B 2 187 ? 168.459 217.298 345.787 1.00 50.52  ? 187 HIS B CB  1 
ATOM 2336 C CG  . HIS B 2 187 ? 168.570 216.204 346.801 1.00 51.57  ? 187 HIS B CG  1 
ATOM 2337 N ND1 . HIS B 2 187 ? 168.386 214.876 346.486 1.00 48.35  ? 187 HIS B ND1 1 
ATOM 2338 C CD2 . HIS B 2 187 ? 168.860 216.241 348.122 1.00 53.78  ? 187 HIS B CD2 1 
ATOM 2339 C CE1 . HIS B 2 187 ? 168.551 214.142 347.571 1.00 48.69  ? 187 HIS B CE1 1 
ATOM 2340 N NE2 . HIS B 2 187 ? 168.840 214.946 348.578 1.00 48.87  ? 187 HIS B NE2 1 
ATOM 2341 N N   . GLN B 2 188 ? 166.946 220.187 345.266 1.00 45.78  ? 188 GLN B N   1 
ATOM 2342 C CA  . GLN B 2 188 ? 166.949 221.446 344.538 1.00 45.91  ? 188 GLN B CA  1 
ATOM 2343 C C   . GLN B 2 188 ? 168.005 222.369 345.122 1.00 51.22  ? 188 GLN B C   1 
ATOM 2344 O O   . GLN B 2 188 ? 168.164 222.453 346.342 1.00 49.74  ? 188 GLN B O   1 
ATOM 2345 C CB  . GLN B 2 188 ? 165.580 222.123 344.594 1.00 47.30  ? 188 GLN B CB  1 
ATOM 2346 C CG  . GLN B 2 188 ? 165.182 222.598 345.973 1.00 43.61  ? 188 GLN B CG  1 
ATOM 2347 C CD  . GLN B 2 188 ? 163.783 223.164 346.004 1.00 49.85  ? 188 GLN B CD  1 
ATOM 2348 O OE1 . GLN B 2 188 ? 162.878 222.640 345.358 1.00 49.63  ? 188 GLN B OE1 1 
ATOM 2349 N NE2 . GLN B 2 188 ? 163.597 224.243 346.751 1.00 50.46  ? 188 GLN B NE2 1 
ATOM 2350 N N   . GLY B 2 189 ? 168.716 223.062 344.245 1.00 47.22  ? 189 GLY B N   1 
ATOM 2351 C CA  . GLY B 2 189 ? 169.754 223.974 344.678 1.00 43.51  ? 189 GLY B CA  1 
ATOM 2352 C C   . GLY B 2 189 ? 170.575 224.429 343.494 1.00 43.33  ? 189 GLY B C   1 
ATOM 2353 O O   . GLY B 2 189 ? 170.304 224.073 342.343 1.00 39.42  ? 189 GLY B O   1 
ATOM 2354 N N   . ALA B 2 190 ? 171.592 225.229 343.799 1.00 41.62  ? 190 ALA B N   1 
ATOM 2355 C CA  . ALA B 2 190 ? 172.473 225.749 342.763 1.00 40.18  ? 190 ALA B CA  1 
ATOM 2356 C C   . ALA B 2 190 ? 173.800 226.140 343.389 1.00 46.60  ? 190 ALA B C   1 
ATOM 2357 O O   . ALA B 2 190 ? 173.825 226.810 344.424 1.00 53.53  ? 190 ALA B O   1 
ATOM 2358 C CB  . ALA B 2 190 ? 171.843 226.950 342.060 1.00 40.88  ? 190 ALA B CB  1 
ATOM 2359 N N   . LEU B 2 191 ? 174.891 225.730 342.755 1.00 49.43  ? 191 LEU B N   1 
ATOM 2360 C CA  . LEU B 2 191 ? 176.238 226.084 343.170 1.00 49.18  ? 191 LEU B CA  1 
ATOM 2361 C C   . LEU B 2 191 ? 176.875 227.000 342.140 1.00 47.00  ? 191 LEU B C   1 
ATOM 2362 O O   . LEU B 2 191 ? 176.615 226.891 340.940 1.00 58.12  ? 191 LEU B O   1 
ATOM 2363 C CB  . LEU B 2 191 ? 177.121 224.847 343.330 1.00 46.03  ? 191 LEU B CB  1 
ATOM 2364 C CG  . LEU B 2 191 ? 176.883 223.956 344.539 1.00 47.12  ? 191 LEU B CG  1 
ATOM 2365 C CD1 . LEU B 2 191 ? 177.738 222.719 344.428 1.00 46.56  ? 191 LEU B CD1 1 
ATOM 2366 C CD2 . LEU B 2 191 ? 177.189 224.700 345.819 1.00 48.89  ? 191 LEU B CD2 1 
ATOM 2367 N N   . GLY B 2 192 ? 177.719 227.899 342.624 1.00 36.47  ? 192 GLY B N   1 
ATOM 2368 C CA  . GLY B 2 192 ? 178.590 228.664 341.764 1.00 44.92  ? 192 GLY B CA  1 
ATOM 2369 C C   . GLY B 2 192 ? 180.025 228.271 342.028 1.00 55.20  ? 192 GLY B C   1 
ATOM 2370 O O   . GLY B 2 192 ? 180.479 228.309 343.177 1.00 61.61  ? 192 GLY B O   1 
ATOM 2371 N N   . VAL B 2 193 ? 180.733 227.863 340.981 1.00 51.54  ? 193 VAL B N   1 
ATOM 2372 C CA  . VAL B 2 193 ? 182.139 227.498 341.054 1.00 45.16  ? 193 VAL B CA  1 
ATOM 2373 C C   . VAL B 2 193 ? 182.915 228.625 340.395 1.00 47.76  ? 193 VAL B C   1 
ATOM 2374 O O   . VAL B 2 193 ? 182.764 228.862 339.191 1.00 61.42  ? 193 VAL B O   1 
ATOM 2375 C CB  . VAL B 2 193 ? 182.414 226.160 340.358 1.00 47.20  ? 193 VAL B CB  1 
ATOM 2376 C CG1 . VAL B 2 193 ? 183.825 225.687 340.650 1.00 54.28  ? 193 VAL B CG1 1 
ATOM 2377 C CG2 . VAL B 2 193 ? 181.390 225.121 340.779 1.00 50.28  ? 193 VAL B CG2 1 
ATOM 2378 N N   . PHE B 2 194 ? 183.738 229.324 341.172 1.00 44.52  ? 194 PHE B N   1 
ATOM 2379 C CA  . PHE B 2 194 ? 184.510 230.459 340.687 1.00 50.26  ? 194 PHE B CA  1 
ATOM 2380 C C   . PHE B 2 194 ? 185.991 230.131 340.767 1.00 52.68  ? 194 PHE B C   1 
ATOM 2381 O O   . PHE B 2 194 ? 186.487 229.744 341.829 1.00 61.02  ? 194 PHE B O   1 
ATOM 2382 C CB  . PHE B 2 194 ? 184.222 231.719 341.504 1.00 50.88  ? 194 PHE B CB  1 
ATOM 2383 C CG  . PHE B 2 194 ? 182.766 231.964 341.748 1.00 53.07  ? 194 PHE B CG  1 
ATOM 2384 C CD1 . PHE B 2 194 ? 181.910 232.229 340.697 1.00 51.53  ? 194 PHE B CD1 1 
ATOM 2385 C CD2 . PHE B 2 194 ? 182.255 231.940 343.032 1.00 51.16  ? 194 PHE B CD2 1 
ATOM 2386 C CE1 . PHE B 2 194 ? 180.573 232.455 340.921 1.00 50.25  ? 194 PHE B CE1 1 
ATOM 2387 C CE2 . PHE B 2 194 ? 180.920 232.167 343.260 1.00 54.60  ? 194 PHE B CE2 1 
ATOM 2388 C CZ  . PHE B 2 194 ? 180.078 232.425 342.203 1.00 53.64  ? 194 PHE B CZ  1 
ATOM 2389 N N   . ALA B 2 195 ? 186.692 230.295 339.650 1.00 39.50  ? 195 ALA B N   1 
ATOM 2390 C CA  . ALA B 2 195 ? 188.138 230.103 339.589 1.00 41.43  ? 195 ALA B CA  1 
ATOM 2391 C C   . ALA B 2 195 ? 188.780 231.471 339.781 1.00 44.96  ? 195 ALA B C   1 
ATOM 2392 O O   . ALA B 2 195 ? 189.063 232.185 338.822 1.00 49.59  ? 195 ALA B O   1 
ATOM 2393 C CB  . ALA B 2 195 ? 188.547 229.462 338.271 1.00 46.46  ? 195 ALA B CB  1 
ATOM 2394 N N   . VAL B 2 196 ? 189.015 231.829 341.038 1.00 54.50  ? 196 VAL B N   1 
ATOM 2395 C CA  . VAL B 2 196 ? 189.456 233.170 341.410 1.00 52.70  ? 196 VAL B CA  1 
ATOM 2396 C C   . VAL B 2 196 ? 190.972 233.284 341.302 1.00 52.44  ? 196 VAL B C   1 
ATOM 2397 O O   . VAL B 2 196 ? 191.679 232.820 342.206 1.00 62.52  ? 196 VAL B O   1 
ATOM 2398 C CB  . VAL B 2 196 ? 189.001 233.509 342.837 1.00 50.61  ? 196 VAL B CB  1 
ATOM 2399 C CG1 . VAL B 2 196 ? 189.459 234.899 343.223 1.00 55.56  ? 196 VAL B CG1 1 
ATOM 2400 C CG2 . VAL B 2 196 ? 187.495 233.383 342.956 1.00 58.09  ? 196 VAL B CG2 1 
ATOM 2401 N N   . PRO B 2 197 ? 191.524 233.892 340.251 1.00 52.61  ? 197 PRO B N   1 
ATOM 2402 C CA  . PRO B 2 197 ? 192.976 234.087 340.213 1.00 54.18  ? 197 PRO B CA  1 
ATOM 2403 C C   . PRO B 2 197 ? 193.431 235.003 341.336 1.00 56.32  ? 197 PRO B C   1 
ATOM 2404 O O   . PRO B 2 197 ? 192.754 235.970 341.685 1.00 59.50  ? 197 PRO B O   1 
ATOM 2405 C CB  . PRO B 2 197 ? 193.215 234.715 338.837 1.00 45.12  ? 197 PRO B CB  1 
ATOM 2406 C CG  . PRO B 2 197 ? 191.946 235.375 338.509 1.00 53.90  ? 197 PRO B CG  1 
ATOM 2407 C CD  . PRO B 2 197 ? 190.872 234.503 339.082 1.00 49.92  ? 197 PRO B CD  1 
ATOM 2408 N N   . GLU B 2 198 ? 194.595 234.692 341.899 1.00 56.57  ? 198 GLU B N   1 
ATOM 2409 C CA  . GLU B 2 198 ? 195.152 235.464 343.004 1.00 55.65  ? 198 GLU B CA  1 
ATOM 2410 C C   . GLU B 2 198 ? 194.106 235.675 344.094 1.00 63.00  ? 198 GLU B C   1 
ATOM 2411 O O   . GLU B 2 198 ? 193.892 236.786 344.581 1.00 68.41  ? 198 GLU B O   1 
ATOM 2412 C CB  . GLU B 2 198 ? 195.698 236.801 342.512 1.00 57.96  ? 198 GLU B CB  1 
ATOM 2413 C CG  . GLU B 2 198 ? 196.752 236.678 341.437 1.00 61.98  ? 198 GLU B CG  1 
ATOM 2414 C CD  . GLU B 2 198 ? 198.006 235.994 341.929 1.00 68.27  ? 198 GLU B CD  1 
ATOM 2415 O OE1 . GLU B 2 198 ? 198.142 235.803 343.156 1.00 70.07  ? 198 GLU B OE1 1 
ATOM 2416 O OE2 . GLU B 2 198 ? 198.860 235.647 341.087 1.00 65.58  ? 198 GLU B OE2 1 
ATOM 2417 N N   . MET B 2 199 ? 193.447 234.590 344.478 1.00 69.28  ? 199 MET B N   1 
ATOM 2418 C CA  . MET B 2 199 ? 192.355 234.664 345.443 1.00 66.99  ? 199 MET B CA  1 
ATOM 2419 C C   . MET B 2 199 ? 192.933 234.992 346.810 1.00 68.91  ? 199 MET B C   1 
ATOM 2420 O O   . MET B 2 199 ? 193.432 234.114 347.516 1.00 71.35  ? 199 MET B O   1 
ATOM 2421 C CB  . MET B 2 199 ? 191.583 233.351 345.474 1.00 69.47  ? 199 MET B CB  1 
ATOM 2422 C CG  . MET B 2 199 ? 190.343 233.381 346.347 1.00 66.74  ? 199 MET B CG  1 
ATOM 2423 S SD  . MET B 2 199 ? 189.344 231.893 346.180 1.00 74.80  ? 199 MET B SD  1 
ATOM 2424 C CE  . MET B 2 199 ? 190.434 230.662 346.882 1.00 69.39  ? 199 MET B CE  1 
ATOM 2425 N N   . CYS B 2 200 ? 192.866 236.263 347.189 1.00 80.51  ? 200 CYS B N   1 
ATOM 2426 C CA  . CYS B 2 200 ? 193.329 236.726 348.494 1.00 84.39  ? 200 CYS B CA  1 
ATOM 2427 C C   . CYS B 2 200 ? 192.116 236.832 349.410 1.00 85.14  ? 200 CYS B C   1 
ATOM 2428 O O   . CYS B 2 200 ? 191.394 237.831 349.390 1.00 87.26  ? 200 CYS B O   1 
ATOM 2429 C CB  . CYS B 2 200 ? 194.053 238.062 348.371 1.00 87.75  ? 200 CYS B CB  1 
ATOM 2430 S SG  . CYS B 2 200 ? 195.581 237.998 347.417 1.00 95.82  ? 200 CYS B SG  1 
ATOM 2431 N N   . LEU B 2 201 ? 191.889 235.792 350.212 1.00 81.11  ? 201 LEU B N   1 
ATOM 2432 C CA  . LEU B 2 201 ? 190.797 235.790 351.184 1.00 87.02  ? 201 LEU B CA  1 
ATOM 2433 C C   . LEU B 2 201 ? 191.307 236.437 352.467 1.00 85.35  ? 201 LEU B C   1 
ATOM 2434 O O   . LEU B 2 201 ? 191.636 235.774 353.452 1.00 89.04  ? 201 LEU B O   1 
ATOM 2435 C CB  . LEU B 2 201 ? 190.290 234.375 351.429 1.00 84.17  ? 201 LEU B CB  1 
ATOM 2436 C CG  . LEU B 2 201 ? 189.785 233.594 350.216 1.00 80.60  ? 201 LEU B CG  1 
ATOM 2437 C CD1 . LEU B 2 201 ? 189.238 232.255 350.658 1.00 81.33  ? 201 LEU B CD1 1 
ATOM 2438 C CD2 . LEU B 2 201 ? 188.725 234.371 349.461 1.00 79.60  ? 201 LEU B CD2 1 
ATOM 2439 N N   . ALA B 2 202 ? 191.379 237.766 352.445 1.00 95.50  ? 202 ALA B N   1 
ATOM 2440 C CA  . ALA B 2 202 ? 191.840 238.533 353.601 1.00 98.63  ? 202 ALA B CA  1 
ATOM 2441 C C   . ALA B 2 202 ? 190.699 238.717 354.605 1.00 101.14 ? 202 ALA B C   1 
ATOM 2442 O O   . ALA B 2 202 ? 190.252 239.825 354.900 1.00 102.85 ? 202 ALA B O   1 
ATOM 2443 C CB  . ALA B 2 202 ? 192.405 239.874 353.151 1.00 98.27  ? 202 ALA B CB  1 
ATOM 2444 N N   . GLY B 2 203 ? 190.230 237.591 355.132 1.00 95.13  ? 203 GLY B N   1 
ATOM 2445 C CA  . GLY B 2 203 ? 189.143 237.593 356.092 1.00 92.78  ? 203 GLY B CA  1 
ATOM 2446 C C   . GLY B 2 203 ? 187.874 238.207 355.536 1.00 93.65  ? 203 GLY B C   1 
ATOM 2447 O O   . GLY B 2 203 ? 187.162 238.927 356.236 1.00 94.01  ? 203 GLY B O   1 
ATOM 2448 N N   . THR B 2 212 ? 197.123 237.644 357.707 1.00 110.88 ? 212 THR B N   1 
ATOM 2449 C CA  . THR B 2 212 ? 196.740 236.355 357.144 1.00 112.82 ? 212 THR B CA  1 
ATOM 2450 C C   . THR B 2 212 ? 197.937 235.413 357.105 1.00 111.29 ? 212 THR B C   1 
ATOM 2451 O O   . THR B 2 212 ? 198.738 235.452 356.173 1.00 111.36 ? 212 THR B O   1 
ATOM 2452 C CB  . THR B 2 212 ? 196.168 236.508 355.723 1.00 113.13 ? 212 THR B CB  1 
ATOM 2453 O OG1 . THR B 2 212 ? 197.198 236.952 354.831 1.00 114.29 ? 212 THR B OG1 1 
ATOM 2454 C CG2 . THR B 2 212 ? 195.027 237.512 355.713 1.00 109.90 ? 212 THR B CG2 1 
ATOM 2455 N N   . SER B 2 213 ? 198.048 234.563 358.121 1.00 106.26 ? 213 SER B N   1 
ATOM 2456 C CA  . SER B 2 213 ? 199.182 233.655 358.213 1.00 105.38 ? 213 SER B CA  1 
ATOM 2457 C C   . SER B 2 213 ? 199.168 232.659 357.060 1.00 105.57 ? 213 SER B C   1 
ATOM 2458 O O   . SER B 2 213 ? 198.114 232.297 356.532 1.00 105.61 ? 213 SER B O   1 
ATOM 2459 C CB  . SER B 2 213 ? 199.156 232.908 359.546 1.00 104.61 ? 213 SER B CB  1 
ATOM 2460 O OG  . SER B 2 213 ? 200.177 231.928 359.598 1.00 104.61 ? 213 SER B OG  1 
ATOM 2461 N N   . TYR B 2 214 ? 200.364 232.214 356.670 1.00 102.10 ? 214 TYR B N   1 
ATOM 2462 C CA  . TYR B 2 214 ? 200.475 231.218 355.612 1.00 102.38 ? 214 TYR B CA  1 
ATOM 2463 C C   . TYR B 2 214 ? 199.750 229.930 355.967 1.00 100.39 ? 214 TYR B C   1 
ATOM 2464 O O   . TYR B 2 214 ? 199.378 229.172 355.065 1.00 96.94  ? 214 TYR B O   1 
ATOM 2465 C CB  . TYR B 2 214 ? 201.948 230.926 355.321 1.00 103.64 ? 214 TYR B CB  1 
ATOM 2466 C CG  . TYR B 2 214 ? 202.166 229.838 354.295 1.00 104.01 ? 214 TYR B CG  1 
ATOM 2467 C CD1 . TYR B 2 214 ? 201.923 230.068 352.949 1.00 104.09 ? 214 TYR B CD1 1 
ATOM 2468 C CD2 . TYR B 2 214 ? 202.624 228.584 354.671 1.00 99.59  ? 214 TYR B CD2 1 
ATOM 2469 C CE1 . TYR B 2 214 ? 202.123 229.078 352.006 1.00 102.49 ? 214 TYR B CE1 1 
ATOM 2470 C CE2 . TYR B 2 214 ? 202.827 227.588 353.735 1.00 101.03 ? 214 TYR B CE2 1 
ATOM 2471 C CZ  . TYR B 2 214 ? 202.575 227.841 352.404 1.00 101.45 ? 214 TYR B CZ  1 
ATOM 2472 O OH  . TYR B 2 214 ? 202.776 226.853 351.468 1.00 99.05  ? 214 TYR B OH  1 
ATOM 2473 N N   . GLN B 2 215 ? 199.541 229.665 357.257 1.00 103.18 ? 215 GLN B N   1 
ATOM 2474 C CA  . GLN B 2 215 ? 198.793 228.488 357.674 1.00 104.72 ? 215 GLN B CA  1 
ATOM 2475 C C   . GLN B 2 215 ? 197.292 228.656 357.485 1.00 104.41 ? 215 GLN B C   1 
ATOM 2476 O O   . GLN B 2 215 ? 196.566 227.656 357.482 1.00 101.43 ? 215 GLN B O   1 
ATOM 2477 C CB  . GLN B 2 215 ? 199.090 228.172 359.141 1.00 103.01 ? 215 GLN B CB  1 
ATOM 2478 C CG  . GLN B 2 215 ? 200.574 228.089 359.468 1.00 104.14 ? 215 GLN B CG  1 
ATOM 2479 C CD  . GLN B 2 215 ? 201.324 227.110 358.581 1.00 104.33 ? 215 GLN B CD  1 
ATOM 2480 O OE1 . GLN B 2 215 ? 202.473 227.350 358.211 1.00 103.74 ? 215 GLN B OE1 1 
ATOM 2481 N NE2 . GLN B 2 215 ? 200.681 225.996 358.243 1.00 102.94 ? 215 GLN B NE2 1 
ATOM 2482 N N   . ASN B 2 216 ? 196.814 229.889 357.324 1.00 103.50 ? 216 ASN B N   1 
ATOM 2483 C CA  . ASN B 2 216 ? 195.393 230.161 357.157 1.00 100.63 ? 216 ASN B CA  1 
ATOM 2484 C C   . ASN B 2 216 ? 194.975 230.304 355.702 1.00 100.14 ? 216 ASN B C   1 
ATOM 2485 O O   . ASN B 2 216 ? 193.847 229.937 355.359 1.00 100.25 ? 216 ASN B O   1 
ATOM 2486 C CB  . ASN B 2 216 ? 195.010 231.439 357.909 1.00 100.94 ? 216 ASN B CB  1 
ATOM 2487 C CG  . ASN B 2 216 ? 195.072 231.271 359.413 1.00 101.45 ? 216 ASN B CG  1 
ATOM 2488 O OD1 . ASN B 2 216 ? 195.530 230.245 359.916 1.00 103.48 ? 216 ASN B OD1 1 
ATOM 2489 N ND2 . ASN B 2 216 ? 194.612 232.281 360.141 1.00 99.49  ? 216 ASN B ND2 1 
ATOM 2490 N N   . ALA B 2 217 ? 195.847 230.826 354.843 1.00 95.45  ? 217 ALA B N   1 
ATOM 2491 C CA  . ALA B 2 217 ? 195.525 231.048 353.441 1.00 92.94  ? 217 ALA B CA  1 
ATOM 2492 C C   . ALA B 2 217 ? 195.999 229.917 352.538 1.00 94.15  ? 217 ALA B C   1 
ATOM 2493 O O   . ALA B 2 217 ? 195.830 230.003 351.319 1.00 92.78  ? 217 ALA B O   1 
ATOM 2494 C CB  . ALA B 2 217 ? 196.127 232.372 352.969 1.00 90.57  ? 217 ALA B CB  1 
ATOM 2495 N N   . ASN B 2 218 ? 196.594 228.868 353.099 1.00 89.40  ? 218 ASN B N   1 
ATOM 2496 C CA  . ASN B 2 218 ? 197.032 227.697 352.340 1.00 86.85  ? 218 ASN B CA  1 
ATOM 2497 C C   . ASN B 2 218 ? 196.609 226.441 353.090 1.00 85.01  ? 218 ASN B C   1 
ATOM 2498 O O   . ASN B 2 218 ? 197.443 225.730 353.665 1.00 81.36  ? 218 ASN B O   1 
ATOM 2499 C CB  . ASN B 2 218 ? 198.543 227.726 352.109 1.00 88.12  ? 218 ASN B CB  1 
ATOM 2500 C CG  . ASN B 2 218 ? 198.949 228.730 351.046 1.00 89.14  ? 218 ASN B CG  1 
ATOM 2501 O OD1 . ASN B 2 218 ? 199.199 228.368 349.897 1.00 86.57  ? 218 ASN B OD1 1 
ATOM 2502 N ND2 . ASN B 2 218 ? 199.011 230.001 351.424 1.00 87.53  ? 218 ASN B ND2 1 
ATOM 2503 N N   . PRO B 2 219 ? 195.308 226.138 353.107 1.00 88.98  ? 219 PRO B N   1 
ATOM 2504 C CA  . PRO B 2 219 ? 194.849 224.980 353.890 1.00 89.51  ? 219 PRO B CA  1 
ATOM 2505 C C   . PRO B 2 219 ? 195.193 223.646 353.251 1.00 90.84  ? 219 PRO B C   1 
ATOM 2506 O O   . PRO B 2 219 ? 195.532 222.695 353.966 1.00 84.50  ? 219 PRO B O   1 
ATOM 2507 C CB  . PRO B 2 219 ? 193.335 225.206 353.974 1.00 82.19  ? 219 PRO B CB  1 
ATOM 2508 C CG  . PRO B 2 219 ? 193.009 225.951 352.727 1.00 80.39  ? 219 PRO B CG  1 
ATOM 2509 C CD  . PRO B 2 219 ? 194.197 226.824 352.426 1.00 82.43  ? 219 PRO B CD  1 
ATOM 2510 N N   . GLY B 2 220 ? 195.109 223.543 351.927 1.00 91.19  ? 220 GLY B N   1 
ATOM 2511 C CA  . GLY B 2 220 ? 195.468 222.316 351.242 1.00 85.22  ? 220 GLY B CA  1 
ATOM 2512 C C   . GLY B 2 220 ? 194.278 221.476 350.827 1.00 83.99  ? 220 GLY B C   1 
ATOM 2513 O O   . GLY B 2 220 ? 193.286 221.998 350.312 1.00 82.53  ? 220 GLY B O   1 
ATOM 2514 N N   . GLU B 2 221 ? 194.371 220.162 351.049 1.00 86.05  ? 221 GLU B N   1 
ATOM 2515 C CA  . GLU B 2 221 ? 193.313 219.260 350.601 1.00 86.70  ? 221 GLU B CA  1 
ATOM 2516 C C   . GLU B 2 221 ? 192.018 219.500 351.362 1.00 84.85  ? 221 GLU B C   1 
ATOM 2517 O O   . GLU B 2 221 ? 190.929 219.327 350.804 1.00 81.28  ? 221 GLU B O   1 
ATOM 2518 C CB  . GLU B 2 221 ? 193.742 217.800 350.763 1.00 86.44  ? 221 GLU B CB  1 
ATOM 2519 C CG  . GLU B 2 221 ? 195.231 217.536 350.576 1.00 88.65  ? 221 GLU B CG  1 
ATOM 2520 C CD  . GLU B 2 221 ? 196.004 217.614 351.879 1.00 90.48  ? 221 GLU B CD  1 
ATOM 2521 O OE1 . GLU B 2 221 ? 195.473 217.165 352.917 1.00 88.29  ? 221 GLU B OE1 1 
ATOM 2522 O OE2 . GLU B 2 221 ? 197.140 218.132 351.868 1.00 89.99  ? 221 GLU B OE2 1 
ATOM 2523 N N   . LYS B 2 222 ? 192.113 219.885 352.636 1.00 85.89  ? 222 LYS B N   1 
ATOM 2524 C CA  . LYS B 2 222 ? 190.911 220.175 353.409 1.00 84.42  ? 222 LYS B CA  1 
ATOM 2525 C C   . LYS B 2 222 ? 190.051 221.221 352.715 1.00 86.84  ? 222 LYS B C   1 
ATOM 2526 O O   . LYS B 2 222 ? 188.817 221.154 352.764 1.00 84.35  ? 222 LYS B O   1 
ATOM 2527 C CB  . LYS B 2 222 ? 191.291 220.658 354.809 1.00 84.01  ? 222 LYS B CB  1 
ATOM 2528 C CG  . LYS B 2 222 ? 191.850 219.586 355.724 1.00 86.98  ? 222 LYS B CG  1 
ATOM 2529 C CD  . LYS B 2 222 ? 190.796 218.556 356.084 1.00 86.02  ? 222 LYS B CD  1 
ATOM 2530 C CE  . LYS B 2 222 ? 191.148 217.841 357.376 1.00 85.42  ? 222 LYS B CE  1 
ATOM 2531 N NZ  . LYS B 2 222 ? 192.570 217.407 357.406 1.00 84.92  ? 222 LYS B NZ  1 
ATOM 2532 N N   . GLY B 2 223 ? 190.682 222.192 352.065 1.00 80.60  ? 223 GLY B N   1 
ATOM 2533 C CA  . GLY B 2 223 ? 189.957 223.322 351.526 1.00 74.35  ? 223 GLY B CA  1 
ATOM 2534 C C   . GLY B 2 223 ? 189.650 224.324 352.616 1.00 72.64  ? 223 GLY B C   1 
ATOM 2535 O O   . GLY B 2 223 ? 190.538 224.705 353.383 1.00 78.63  ? 223 GLY B O   1 
ATOM 2536 N N   . GLY B 2 224 ? 188.404 224.746 352.708 1.00 71.30  ? 224 GLY B N   1 
ATOM 2537 C CA  . GLY B 2 224 ? 188.013 225.684 353.731 1.00 73.92  ? 224 GLY B CA  1 
ATOM 2538 C C   . GLY B 2 224 ? 186.515 225.788 353.828 1.00 77.39  ? 224 GLY B C   1 
ATOM 2539 O O   . GLY B 2 224 ? 185.782 224.912 353.369 1.00 79.66  ? 224 GLY B O   1 
ATOM 2540 N N   . THR B 2 225 ? 186.057 226.875 354.441 1.00 72.93  ? 225 THR B N   1 
ATOM 2541 C CA  . THR B 2 225 ? 184.623 227.100 354.596 1.00 77.94  ? 225 THR B CA  1 
ATOM 2542 C C   . THR B 2 225 ? 184.388 228.580 354.839 1.00 77.55  ? 225 THR B C   1 
ATOM 2543 O O   . THR B 2 225 ? 184.882 229.130 355.828 1.00 73.42  ? 225 THR B O   1 
ATOM 2544 C CB  . THR B 2 225 ? 184.060 226.270 355.750 1.00 74.93  ? 225 THR B CB  1 
ATOM 2545 O OG1 . THR B 2 225 ? 184.521 224.918 355.642 1.00 67.71  ? 225 THR B OG1 1 
ATOM 2546 C CG2 . THR B 2 225 ? 182.539 226.280 355.723 1.00 71.52  ? 225 THR B CG2 1 
ATOM 2547 N N   . PHE B 2 226 ? 183.642 229.223 353.944 1.00 78.87  ? 226 PHE B N   1 
ATOM 2548 C CA  . PHE B 2 226 ? 183.218 230.590 354.180 1.00 76.83  ? 226 PHE B CA  1 
ATOM 2549 C C   . PHE B 2 226 ? 182.267 230.639 355.375 1.00 80.18  ? 226 PHE B C   1 
ATOM 2550 O O   . PHE B 2 226 ? 181.908 229.618 355.965 1.00 80.16  ? 226 PHE B O   1 
ATOM 2551 C CB  . PHE B 2 226 ? 182.532 231.164 352.942 1.00 74.32  ? 226 PHE B CB  1 
ATOM 2552 C CG  . PHE B 2 226 ? 183.457 231.403 351.786 1.00 74.00  ? 226 PHE B CG  1 
ATOM 2553 C CD1 . PHE B 2 226 ? 184.212 232.557 351.718 1.00 77.37  ? 226 PHE B CD1 1 
ATOM 2554 C CD2 . PHE B 2 226 ? 183.554 230.488 350.757 1.00 73.78  ? 226 PHE B CD2 1 
ATOM 2555 C CE1 . PHE B 2 226 ? 185.056 232.787 350.651 1.00 76.51  ? 226 PHE B CE1 1 
ATOM 2556 C CE2 . PHE B 2 226 ? 184.395 230.714 349.688 1.00 71.58  ? 226 PHE B CE2 1 
ATOM 2557 C CZ  . PHE B 2 226 ? 185.146 231.864 349.635 1.00 71.88  ? 226 PHE B CZ  1 
ATOM 2558 N N   . THR B 2 227 ? 181.859 231.854 355.734 1.00 88.24  ? 227 THR B N   1 
ATOM 2559 C CA  . THR B 2 227 ? 180.928 232.062 356.831 1.00 88.40  ? 227 THR B CA  1 
ATOM 2560 C C   . THR B 2 227 ? 180.046 233.261 356.519 1.00 88.63  ? 227 THR B C   1 
ATOM 2561 O O   . THR B 2 227 ? 180.392 234.118 355.703 1.00 88.75  ? 227 THR B O   1 
ATOM 2562 C CB  . THR B 2 227 ? 181.652 232.287 358.164 1.00 89.89  ? 227 THR B CB  1 
ATOM 2563 O OG1 . THR B 2 227 ? 182.397 233.509 358.104 1.00 92.22  ? 227 THR B OG1 1 
ATOM 2564 C CG2 . THR B 2 227 ? 182.597 231.133 358.466 1.00 87.97  ? 227 THR B CG2 1 
ATOM 2565 N N   . GLY B 2 228 ? 178.895 233.309 357.182 1.00 83.51  ? 228 GLY B N   1 
ATOM 2566 C CA  . GLY B 2 228 ? 177.961 234.405 357.009 1.00 82.02  ? 228 GLY B CA  1 
ATOM 2567 C C   . GLY B 2 228 ? 178.305 235.605 357.869 1.00 82.54  ? 228 GLY B C   1 
ATOM 2568 O O   . GLY B 2 228 ? 179.371 236.203 357.720 1.00 83.30  ? 228 GLY B O   1 
ATOM 2569 N N   . PHE B 2 243 ? 189.458 230.530 360.770 1.00 96.47  ? 243 PHE B N   1 
ATOM 2570 C CA  . PHE B 2 243 ? 189.444 231.454 359.643 1.00 100.53 ? 243 PHE B CA  1 
ATOM 2571 C C   . PHE B 2 243 ? 188.055 231.490 359.019 1.00 101.94 ? 243 PHE B C   1 
ATOM 2572 O O   . PHE B 2 243 ? 187.563 230.478 358.521 1.00 98.92  ? 243 PHE B O   1 
ATOM 2573 C CB  . PHE B 2 243 ? 190.489 231.046 358.605 1.00 99.93  ? 243 PHE B CB  1 
ATOM 2574 C CG  . PHE B 2 243 ? 190.889 232.157 357.682 1.00 100.38 ? 243 PHE B CG  1 
ATOM 2575 C CD1 . PHE B 2 243 ? 191.539 233.276 358.171 1.00 101.15 ? 243 PHE B CD1 1 
ATOM 2576 C CD2 . PHE B 2 243 ? 190.629 232.080 356.325 1.00 99.30  ? 243 PHE B CD2 1 
ATOM 2577 C CE1 . PHE B 2 243 ? 191.913 234.299 357.329 1.00 100.81 ? 243 PHE B CE1 1 
ATOM 2578 C CE2 . PHE B 2 243 ? 191.004 233.100 355.478 1.00 99.23  ? 243 PHE B CE2 1 
ATOM 2579 C CZ  . PHE B 2 243 ? 191.647 234.211 355.982 1.00 100.85 ? 243 PHE B CZ  1 
ATOM 2580 N N   . CYS B 2 244 ? 187.428 232.666 359.039 1.00 109.07 ? 244 CYS B N   1 
ATOM 2581 C CA  . CYS B 2 244 ? 186.027 232.827 358.655 1.00 107.76 ? 244 CYS B CA  1 
ATOM 2582 C C   . CYS B 2 244 ? 185.892 233.950 357.635 1.00 106.23 ? 244 CYS B C   1 
ATOM 2583 O O   . CYS B 2 244 ? 185.448 235.057 357.969 1.00 105.58 ? 244 CYS B O   1 
ATOM 2584 C CB  . CYS B 2 244 ? 185.160 233.108 359.883 1.00 107.66 ? 244 CYS B CB  1 
ATOM 2585 S SG  . CYS B 2 244 ? 185.327 231.890 361.208 1.00 110.36 ? 244 CYS B SG  1 
ATOM 2586 N N   . PRO B 2 245 ? 186.269 233.705 356.381 1.00 94.46  ? 245 PRO B N   1 
ATOM 2587 C CA  . PRO B 2 245 ? 185.977 234.686 355.332 1.00 92.16  ? 245 PRO B CA  1 
ATOM 2588 C C   . PRO B 2 245 ? 184.477 234.872 355.173 1.00 93.16  ? 245 PRO B C   1 
ATOM 2589 O O   . PRO B 2 245 ? 183.691 233.941 355.356 1.00 93.08  ? 245 PRO B O   1 
ATOM 2590 C CB  . PRO B 2 245 ? 186.604 234.068 354.077 1.00 90.03  ? 245 PRO B CB  1 
ATOM 2591 C CG  . PRO B 2 245 ? 187.603 233.097 354.580 1.00 90.85  ? 245 PRO B CG  1 
ATOM 2592 C CD  . PRO B 2 245 ? 187.053 232.571 355.868 1.00 93.04  ? 245 PRO B CD  1 
ATOM 2593 N N   . VAL B 2 246 ? 184.082 236.093 354.831 1.00 87.80  ? 246 VAL B N   1 
ATOM 2594 C CA  . VAL B 2 246 ? 182.668 236.416 354.678 1.00 88.74  ? 246 VAL B CA  1 
ATOM 2595 C C   . VAL B 2 246 ? 182.215 235.979 353.290 1.00 90.11  ? 246 VAL B C   1 
ATOM 2596 O O   . VAL B 2 246 ? 182.766 236.418 352.276 1.00 86.32  ? 246 VAL B O   1 
ATOM 2597 C CB  . VAL B 2 246 ? 182.412 237.913 354.903 1.00 85.95  ? 246 VAL B CB  1 
ATOM 2598 C CG1 . VAL B 2 246 ? 183.090 238.749 353.826 1.00 83.74  ? 246 VAL B CG1 1 
ATOM 2599 C CG2 . VAL B 2 246 ? 180.917 238.193 354.942 1.00 83.42  ? 246 VAL B CG2 1 
ATOM 2600 N N   . ASP B 2 247 ? 181.214 235.098 353.246 1.00 89.31  ? 247 ASP B N   1 
ATOM 2601 C CA  . ASP B 2 247 ? 180.685 234.647 351.963 1.00 88.27  ? 247 ASP B CA  1 
ATOM 2602 C C   . ASP B 2 247 ? 180.018 235.790 351.211 1.00 88.51  ? 247 ASP B C   1 
ATOM 2603 O O   . ASP B 2 247 ? 180.136 235.885 349.984 1.00 83.89  ? 247 ASP B O   1 
ATOM 2604 C CB  . ASP B 2 247 ? 179.697 233.502 352.175 1.00 89.17  ? 247 ASP B CB  1 
ATOM 2605 C CG  . ASP B 2 247 ? 178.530 233.894 353.060 1.00 91.91  ? 247 ASP B CG  1 
ATOM 2606 O OD1 . ASP B 2 247 ? 177.743 234.776 352.657 1.00 89.37  ? 247 ASP B OD1 1 
ATOM 2607 O OD2 . ASP B 2 247 ? 178.395 233.314 354.158 1.00 93.12  ? 247 ASP B OD2 1 
ATOM 2608 N N   . TYR B 2 248 ? 179.316 236.667 351.933 1.00 88.76  ? 248 TYR B N   1 
ATOM 2609 C CA  . TYR B 2 248 ? 178.576 237.747 351.289 1.00 85.65  ? 248 TYR B CA  1 
ATOM 2610 C C   . TYR B 2 248 ? 179.458 238.531 350.328 1.00 86.32  ? 248 TYR B C   1 
ATOM 2611 O O   . TYR B 2 248 ? 179.022 238.896 349.230 1.00 81.29  ? 248 TYR B O   1 
ATOM 2612 C CB  . TYR B 2 248 ? 177.983 238.669 352.356 1.00 84.56  ? 248 TYR B CB  1 
ATOM 2613 C CG  . TYR B 2 248 ? 177.709 240.080 351.887 1.00 85.10  ? 248 TYR B CG  1 
ATOM 2614 C CD1 . TYR B 2 248 ? 176.916 240.326 350.774 1.00 87.45  ? 248 TYR B CD1 1 
ATOM 2615 C CD2 . TYR B 2 248 ? 178.230 241.169 352.572 1.00 85.71  ? 248 TYR B CD2 1 
ATOM 2616 C CE1 . TYR B 2 248 ? 176.664 241.616 350.349 1.00 88.68  ? 248 TYR B CE1 1 
ATOM 2617 C CE2 . TYR B 2 248 ? 177.980 242.460 352.157 1.00 86.51  ? 248 TYR B CE2 1 
ATOM 2618 C CZ  . TYR B 2 248 ? 177.198 242.679 351.045 1.00 89.10  ? 248 TYR B CZ  1 
ATOM 2619 O OH  . TYR B 2 248 ? 176.948 243.967 350.630 1.00 89.37  ? 248 TYR B OH  1 
ATOM 2620 N N   . LEU B 2 249 ? 180.703 238.794 350.719 1.00 91.88  ? 249 LEU B N   1 
ATOM 2621 C CA  . LEU B 2 249 ? 181.655 239.503 349.879 1.00 88.06  ? 249 LEU B CA  1 
ATOM 2622 C C   . LEU B 2 249 ? 182.613 238.563 349.159 1.00 84.76  ? 249 LEU B C   1 
ATOM 2623 O O   . LEU B 2 249 ? 183.582 239.028 348.552 1.00 81.28  ? 249 LEU B O   1 
ATOM 2624 C CB  . LEU B 2 249 ? 182.450 240.506 350.717 1.00 85.64  ? 249 LEU B CB  1 
ATOM 2625 C CG  . LEU B 2 249 ? 181.613 241.494 351.529 1.00 87.17  ? 249 LEU B CG  1 
ATOM 2626 C CD1 . LEU B 2 249 ? 182.492 242.322 352.447 1.00 87.56  ? 249 LEU B CD1 1 
ATOM 2627 C CD2 . LEU B 2 249 ? 180.814 242.393 350.605 1.00 83.50  ? 249 LEU B CD2 1 
ATOM 2628 N N   . LEU B 2 250 ? 182.370 237.254 349.215 1.00 73.92  ? 250 LEU B N   1 
ATOM 2629 C CA  . LEU B 2 250 ? 183.259 236.239 348.662 1.00 76.23  ? 250 LEU B CA  1 
ATOM 2630 C C   . LEU B 2 250 ? 184.597 236.202 349.387 1.00 79.97  ? 250 LEU B C   1 
ATOM 2631 O O   . LEU B 2 250 ? 185.534 235.546 348.916 1.00 81.38  ? 250 LEU B O   1 
ATOM 2632 C CB  . LEU B 2 250 ? 183.495 236.456 347.162 1.00 73.89  ? 250 LEU B CB  1 
ATOM 2633 C CG  . LEU B 2 250 ? 184.068 235.290 346.350 1.00 71.85  ? 250 LEU B CG  1 
ATOM 2634 C CD1 . LEU B 2 250 ? 183.096 234.132 346.322 1.00 78.80  ? 250 LEU B CD1 1 
ATOM 2635 C CD2 . LEU B 2 250 ? 184.402 235.734 344.939 1.00 65.68  ? 250 LEU B CD2 1 
ATOM 2636 N N   . GLY B 2 251 ? 184.715 236.888 350.522 1.00 85.47  ? 251 GLY B N   1 
ATOM 2637 C CA  . GLY B 2 251 ? 185.970 236.992 351.231 1.00 85.68  ? 251 GLY B CA  1 
ATOM 2638 C C   . GLY B 2 251 ? 186.920 238.030 350.680 1.00 83.41  ? 251 GLY B C   1 
ATOM 2639 O O   . GLY B 2 251 ? 188.013 238.199 351.235 1.00 80.16  ? 251 GLY B O   1 
ATOM 2640 N N   . ASN B 2 252 ? 186.542 238.733 349.614 1.00 85.04  ? 252 ASN B N   1 
ATOM 2641 C CA  . ASN B 2 252 ? 187.409 239.700 348.956 1.00 90.85  ? 252 ASN B CA  1 
ATOM 2642 C C   . ASN B 2 252 ? 186.963 241.140 349.185 1.00 91.57  ? 252 ASN B C   1 
ATOM 2643 O O   . ASN B 2 252 ? 187.501 242.054 348.551 1.00 90.80  ? 252 ASN B O   1 
ATOM 2644 C CB  . ASN B 2 252 ? 187.469 239.403 347.455 1.00 88.46  ? 252 ASN B CB  1 
ATOM 2645 C CG  . ASN B 2 252 ? 188.696 239.995 346.789 1.00 90.65  ? 252 ASN B CG  1 
ATOM 2646 O OD1 . ASN B 2 252 ? 189.743 240.156 347.416 1.00 88.66  ? 252 ASN B OD1 1 
ATOM 2647 N ND2 . ASN B 2 252 ? 188.573 240.318 345.507 1.00 88.45  ? 252 ASN B ND2 1 
ATOM 2648 N N   . GLY B 2 253 ? 185.994 241.367 350.068 1.00 87.98  ? 253 GLY B N   1 
ATOM 2649 C CA  . GLY B 2 253 ? 185.482 242.701 350.296 1.00 84.57  ? 253 GLY B CA  1 
ATOM 2650 C C   . GLY B 2 253 ? 184.560 243.220 349.217 1.00 88.15  ? 253 GLY B C   1 
ATOM 2651 O O   . GLY B 2 253 ? 184.168 244.391 349.271 1.00 88.86  ? 253 GLY B O   1 
ATOM 2652 N N   . THR B 2 254 ? 184.185 242.384 348.252 1.00 90.00  ? 254 THR B N   1 
ATOM 2653 C CA  . THR B 2 254 ? 183.399 242.789 347.095 1.00 88.32  ? 254 THR B CA  1 
ATOM 2654 C C   . THR B 2 254 ? 182.131 241.949 347.010 1.00 89.29  ? 254 THR B C   1 
ATOM 2655 O O   . THR B 2 254 ? 182.162 240.740 347.257 1.00 88.09  ? 254 THR B O   1 
ATOM 2656 C CB  . THR B 2 254 ? 184.208 242.632 345.806 1.00 87.62  ? 254 THR B CB  1 
ATOM 2657 O OG1 . THR B 2 254 ? 183.424 243.071 344.691 1.00 90.56  ? 254 THR B OG1 1 
ATOM 2658 C CG2 . THR B 2 254 ? 184.606 241.178 345.594 1.00 84.83  ? 254 THR B CG2 1 
ATOM 2659 N N   . LEU B 2 255 ? 181.023 242.588 346.633 1.00 83.73  ? 255 LEU B N   1 
ATOM 2660 C CA  . LEU B 2 255 ? 179.731 241.913 346.626 1.00 77.15  ? 255 LEU B CA  1 
ATOM 2661 C C   . LEU B 2 255 ? 179.785 240.646 345.783 1.00 77.20  ? 255 LEU B C   1 
ATOM 2662 O O   . LEU B 2 255 ? 180.435 240.602 344.736 1.00 73.31  ? 255 LEU B O   1 
ATOM 2663 C CB  . LEU B 2 255 ? 178.644 242.846 346.092 1.00 73.82  ? 255 LEU B CB  1 
ATOM 2664 C CG  . LEU B 2 255 ? 178.025 243.804 347.111 1.00 78.52  ? 255 LEU B CG  1 
ATOM 2665 C CD1 . LEU B 2 255 ? 179.065 244.777 347.642 1.00 82.04  ? 255 LEU B CD1 1 
ATOM 2666 C CD2 . LEU B 2 255 ? 176.851 244.552 346.500 1.00 79.09  ? 255 LEU B CD2 1 
ATOM 2667 N N   . LEU B 2 256 ? 179.092 239.608 346.257 1.00 69.81  ? 256 LEU B N   1 
ATOM 2668 C CA  . LEU B 2 256 ? 179.132 238.316 345.581 1.00 63.10  ? 256 LEU B CA  1 
ATOM 2669 C C   . LEU B 2 256 ? 178.556 238.392 344.176 1.00 57.31  ? 256 LEU B C   1 
ATOM 2670 O O   . LEU B 2 256 ? 178.947 237.609 343.305 1.00 50.34  ? 256 LEU B O   1 
ATOM 2671 C CB  . LEU B 2 256 ? 178.373 237.273 346.399 1.00 57.04  ? 256 LEU B CB  1 
ATOM 2672 C CG  . LEU B 2 256 ? 178.171 235.921 345.710 1.00 60.30  ? 256 LEU B CG  1 
ATOM 2673 C CD1 . LEU B 2 256 ? 179.503 235.282 345.375 1.00 60.44  ? 256 LEU B CD1 1 
ATOM 2674 C CD2 . LEU B 2 256 ? 177.338 235.002 346.580 1.00 59.98  ? 256 LEU B CD2 1 
ATOM 2675 N N   . GLY B 2 257 ? 177.622 239.310 343.935 1.00 60.26  ? 257 GLY B N   1 
ATOM 2676 C CA  . GLY B 2 257 ? 177.007 239.384 342.621 1.00 59.90  ? 257 GLY B CA  1 
ATOM 2677 C C   . GLY B 2 257 ? 178.022 239.602 341.517 1.00 59.48  ? 257 GLY B C   1 
ATOM 2678 O O   . GLY B 2 257 ? 177.946 238.977 340.458 1.00 65.68  ? 257 GLY B O   1 
ATOM 2679 N N   . ASN B 2 258 ? 178.989 240.489 341.750 1.00 59.19  ? 258 ASN B N   1 
ATOM 2680 C CA  . ASN B 2 258 ? 180.015 240.753 340.752 1.00 57.14  ? 258 ASN B CA  1 
ATOM 2681 C C   . ASN B 2 258 ? 180.958 239.573 340.567 1.00 57.86  ? 258 ASN B C   1 
ATOM 2682 O O   . ASN B 2 258 ? 181.662 239.510 339.553 1.00 58.68  ? 258 ASN B O   1 
ATOM 2683 C CB  . ASN B 2 258 ? 180.813 241.992 341.149 1.00 59.67  ? 258 ASN B CB  1 
ATOM 2684 C CG  . ASN B 2 258 ? 179.931 243.185 341.428 1.00 64.50  ? 258 ASN B CG  1 
ATOM 2685 O OD1 . ASN B 2 258 ? 179.898 243.699 342.544 1.00 60.41  ? 258 ASN B OD1 1 
ATOM 2686 N ND2 . ASN B 2 258 ? 179.209 243.633 340.412 1.00 67.53  ? 258 ASN B ND2 1 
ATOM 2687 N N   . ALA B 2 259 ? 180.972 238.629 341.511 1.00 53.65  ? 259 ALA B N   1 
ATOM 2688 C CA  . ALA B 2 259 ? 181.913 237.518 341.452 1.00 56.87  ? 259 ALA B CA  1 
ATOM 2689 C C   . ALA B 2 259 ? 181.857 236.772 340.129 1.00 53.01  ? 259 ALA B C   1 
ATOM 2690 O O   . ALA B 2 259 ? 182.787 236.026 339.810 1.00 59.14  ? 259 ALA B O   1 
ATOM 2691 C CB  . ALA B 2 259 ? 181.642 236.543 342.596 1.00 58.02  ? 259 ALA B CB  1 
ATOM 2692 N N   . PHE B 2 260 ? 180.799 236.959 339.347 1.00 44.70  ? 260 PHE B N   1 
ATOM 2693 C CA  . PHE B 2 260 ? 180.666 236.247 338.087 1.00 48.05  ? 260 PHE B CA  1 
ATOM 2694 C C   . PHE B 2 260 ? 181.614 236.761 337.015 1.00 46.15  ? 260 PHE B C   1 
ATOM 2695 O O   . PHE B 2 260 ? 181.633 236.199 335.916 1.00 46.57  ? 260 PHE B O   1 
ATOM 2696 C CB  . PHE B 2 260 ? 179.216 236.325 337.612 1.00 46.88  ? 260 PHE B CB  1 
ATOM 2697 C CG  . PHE B 2 260 ? 178.270 235.533 338.465 1.00 48.08  ? 260 PHE B CG  1 
ATOM 2698 C CD1 . PHE B 2 260 ? 177.972 235.940 339.748 1.00 53.65  ? 260 PHE B CD1 1 
ATOM 2699 C CD2 . PHE B 2 260 ? 177.693 234.374 337.991 1.00 48.91  ? 260 PHE B CD2 1 
ATOM 2700 C CE1 . PHE B 2 260 ? 177.116 235.211 340.534 1.00 50.37  ? 260 PHE B CE1 1 
ATOM 2701 C CE2 . PHE B 2 260 ? 176.836 233.644 338.776 1.00 47.18  ? 260 PHE B CE2 1 
ATOM 2702 C CZ  . PHE B 2 260 ? 176.549 234.063 340.047 1.00 46.78  ? 260 PHE B CZ  1 
ATOM 2703 N N   . VAL B 2 261 ? 182.393 237.808 337.293 1.00 44.55  ? 261 VAL B N   1 
ATOM 2704 C CA  . VAL B 2 261 ? 183.452 238.189 336.365 1.00 44.86  ? 261 VAL B CA  1 
ATOM 2705 C C   . VAL B 2 261 ? 184.524 237.110 336.313 1.00 52.82  ? 261 VAL B C   1 
ATOM 2706 O O   . VAL B 2 261 ? 185.123 236.869 335.258 1.00 49.07  ? 261 VAL B O   1 
ATOM 2707 C CB  . VAL B 2 261 ? 184.051 239.554 336.751 1.00 35.46  ? 261 VAL B CB  1 
ATOM 2708 C CG1 . VAL B 2 261 ? 183.005 240.639 336.629 1.00 45.46  ? 261 VAL B CG1 1 
ATOM 2709 C CG2 . VAL B 2 261 ? 184.622 239.516 338.155 1.00 43.80  ? 261 VAL B CG2 1 
ATOM 2710 N N   . PHE B 2 262 ? 184.786 236.455 337.437 1.00 53.69  ? 262 PHE B N   1 
ATOM 2711 C CA  . PHE B 2 262 ? 185.783 235.398 337.477 1.00 40.75  ? 262 PHE B CA  1 
ATOM 2712 C C   . PHE B 2 262 ? 185.345 234.226 336.603 1.00 45.92  ? 262 PHE B C   1 
ATOM 2713 O O   . PHE B 2 262 ? 184.160 233.884 336.574 1.00 54.61  ? 262 PHE B O   1 
ATOM 2714 C CB  . PHE B 2 262 ? 185.981 234.923 338.910 1.00 37.02  ? 262 PHE B CB  1 
ATOM 2715 C CG  . PHE B 2 262 ? 186.642 235.931 339.795 1.00 38.48  ? 262 PHE B CG  1 
ATOM 2716 C CD1 . PHE B 2 262 ? 187.810 236.552 339.404 1.00 43.12  ? 262 PHE B CD1 1 
ATOM 2717 C CD2 . PHE B 2 262 ? 186.096 236.259 341.018 1.00 37.59  ? 262 PHE B CD2 1 
ATOM 2718 C CE1 . PHE B 2 262 ? 188.421 237.471 340.216 1.00 45.42  ? 262 PHE B CE1 1 
ATOM 2719 C CE2 . PHE B 2 262 ? 186.706 237.182 341.833 1.00 39.79  ? 262 PHE B CE2 1 
ATOM 2720 C CZ  . PHE B 2 262 ? 187.869 237.785 341.432 1.00 43.67  ? 262 PHE B CZ  1 
ATOM 2721 N N   . PRO B 2 263 ? 186.269 233.579 335.895 1.00 42.55  ? 263 PRO B N   1 
ATOM 2722 C CA  . PRO B 2 263 ? 185.880 232.434 335.061 1.00 41.42  ? 263 PRO B CA  1 
ATOM 2723 C C   . PRO B 2 263 ? 185.243 231.359 335.923 1.00 45.00  ? 263 PRO B C   1 
ATOM 2724 O O   . PRO B 2 263 ? 185.890 230.770 336.790 1.00 54.59  ? 263 PRO B O   1 
ATOM 2725 C CB  . PRO B 2 263 ? 187.204 231.976 334.448 1.00 45.09  ? 263 PRO B CB  1 
ATOM 2726 C CG  . PRO B 2 263 ? 188.235 232.441 335.398 1.00 50.62  ? 263 PRO B CG  1 
ATOM 2727 C CD  . PRO B 2 263 ? 187.730 233.728 335.970 1.00 50.45  ? 263 PRO B CD  1 
ATOM 2728 N N   . HIS B 2 264 ? 183.963 231.103 335.675 1.00 43.56  ? 264 HIS B N   1 
ATOM 2729 C CA  . HIS B 2 264 ? 183.131 230.376 336.617 1.00 48.97  ? 264 HIS B CA  1 
ATOM 2730 C C   . HIS B 2 264 ? 182.232 229.403 335.871 1.00 52.27  ? 264 HIS B C   1 
ATOM 2731 O O   . HIS B 2 264 ? 182.305 229.256 334.648 1.00 58.19  ? 264 HIS B O   1 
ATOM 2732 C CB  . HIS B 2 264 ? 182.277 231.346 337.434 1.00 39.32  ? 264 HIS B CB  1 
ATOM 2733 C CG  . HIS B 2 264 ? 181.220 232.024 336.625 1.00 45.58  ? 264 HIS B CG  1 
ATOM 2734 N ND1 . HIS B 2 264 ? 181.477 232.585 335.393 1.00 41.82  ? 264 HIS B ND1 1 
ATOM 2735 C CD2 . HIS B 2 264 ? 179.901 232.215 336.857 1.00 51.54  ? 264 HIS B CD2 1 
ATOM 2736 C CE1 . HIS B 2 264 ? 180.364 233.101 334.905 1.00 45.26  ? 264 HIS B CE1 1 
ATOM 2737 N NE2 . HIS B 2 264 ? 179.393 232.890 335.774 1.00 52.73  ? 264 HIS B NE2 1 
ATOM 2738 N N   . GLN B 2 265 ? 181.382 228.731 336.637 1.00 51.02  ? 265 GLN B N   1 
ATOM 2739 C CA  . GLN B 2 265 ? 180.307 227.920 336.086 1.00 47.54  ? 265 GLN B CA  1 
ATOM 2740 C C   . GLN B 2 265 ? 179.250 227.742 337.164 1.00 52.50  ? 265 GLN B C   1 
ATOM 2741 O O   . GLN B 2 265 ? 179.505 227.959 338.351 1.00 52.90  ? 265 GLN B O   1 
ATOM 2742 C CB  . GLN B 2 265 ? 180.815 226.569 335.579 1.00 40.42  ? 265 GLN B CB  1 
ATOM 2743 C CG  . GLN B 2 265 ? 179.750 225.751 334.874 1.00 52.17  ? 265 GLN B CG  1 
ATOM 2744 C CD  . GLN B 2 265 ? 180.326 224.704 333.946 1.00 60.83  ? 265 GLN B CD  1 
ATOM 2745 O OE1 . GLN B 2 265 ? 181.454 224.829 333.476 1.00 66.88  ? 265 GLN B OE1 1 
ATOM 2746 N NE2 . GLN B 2 265 ? 179.550 223.663 333.674 1.00 54.38  ? 265 GLN B NE2 1 
ATOM 2747 N N   . ILE B 2 266 ? 178.051 227.362 336.735 1.00 47.93  ? 266 ILE B N   1 
ATOM 2748 C CA  . ILE B 2 266 ? 176.909 227.201 337.625 1.00 38.38  ? 266 ILE B CA  1 
ATOM 2749 C C   . ILE B 2 266 ? 176.422 225.765 337.531 1.00 45.83  ? 266 ILE B C   1 
ATOM 2750 O O   . ILE B 2 266 ? 176.191 225.251 336.430 1.00 50.92  ? 266 ILE B O   1 
ATOM 2751 C CB  . ILE B 2 266 ? 175.780 228.187 337.282 1.00 39.10  ? 266 ILE B CB  1 
ATOM 2752 C CG1 . ILE B 2 266 ? 176.246 229.620 337.541 1.00 47.77  ? 266 ILE B CG1 1 
ATOM 2753 C CG2 . ILE B 2 266 ? 174.544 227.872 338.100 1.00 43.56  ? 266 ILE B CG2 1 
ATOM 2754 C CD1 . ILE B 2 266 ? 175.292 230.679 337.046 1.00 44.76  ? 266 ILE B CD1 1 
ATOM 2755 N N   . ILE B 2 267 ? 176.275 225.124 338.682 1.00 43.97  ? 267 ILE B N   1 
ATOM 2756 C CA  . ILE B 2 267 ? 175.777 223.760 338.790 1.00 41.29  ? 267 ILE B CA  1 
ATOM 2757 C C   . ILE B 2 267 ? 174.382 223.858 339.388 1.00 45.07  ? 267 ILE B C   1 
ATOM 2758 O O   . ILE B 2 267 ? 174.231 223.947 340.609 1.00 50.25  ? 267 ILE B O   1 
ATOM 2759 C CB  . ILE B 2 267 ? 176.689 222.886 339.655 1.00 49.43  ? 267 ILE B CB  1 
ATOM 2760 C CG1 . ILE B 2 267 ? 178.050 222.704 338.987 1.00 52.66  ? 267 ILE B CG1 1 
ATOM 2761 C CG2 . ILE B 2 267 ? 176.035 221.542 339.921 1.00 47.15  ? 267 ILE B CG2 1 
ATOM 2762 C CD1 . ILE B 2 267 ? 179.134 222.273 339.942 1.00 47.83  ? 267 ILE B CD1 1 
ATOM 2763 N N   . ASN B 2 268 ? 173.362 223.862 338.540 1.00 49.84  ? 268 ASN B N   1 
ATOM 2764 C CA  . ASN B 2 268 ? 171.978 223.931 338.986 1.00 47.12  ? 268 ASN B CA  1 
ATOM 2765 C C   . ASN B 2 268 ? 171.421 222.516 339.029 1.00 53.95  ? 268 ASN B C   1 
ATOM 2766 O O   . ASN B 2 268 ? 171.435 221.812 338.015 1.00 62.52  ? 268 ASN B O   1 
ATOM 2767 C CB  . ASN B 2 268 ? 171.149 224.813 338.056 1.00 46.61  ? 268 ASN B CB  1 
ATOM 2768 C CG  . ASN B 2 268 ? 169.761 225.071 338.589 1.00 53.23  ? 268 ASN B CG  1 
ATOM 2769 O OD1 . ASN B 2 268 ? 169.440 224.701 339.715 1.00 58.56  ? 268 ASN B OD1 1 
ATOM 2770 N ND2 . ASN B 2 268 ? 168.929 225.719 337.785 1.00 47.62  ? 268 ASN B ND2 1 
ATOM 2771 N N   . LEU B 2 269 ? 170.926 222.101 340.194 1.00 48.10  ? 269 LEU B N   1 
ATOM 2772 C CA  . LEU B 2 269 ? 170.514 220.714 340.348 1.00 47.53  ? 269 LEU B CA  1 
ATOM 2773 C C   . LEU B 2 269 ? 169.115 220.488 339.794 1.00 51.75  ? 269 LEU B C   1 
ATOM 2774 O O   . LEU B 2 269 ? 168.278 219.846 340.436 1.00 58.56  ? 269 LEU B O   1 
ATOM 2775 C CB  . LEU B 2 269 ? 170.560 220.309 341.821 1.00 46.98  ? 269 LEU B CB  1 
ATOM 2776 C CG  . LEU B 2 269 ? 171.939 220.256 342.470 1.00 45.64  ? 269 LEU B CG  1 
ATOM 2777 C CD1 . LEU B 2 269 ? 171.803 219.966 343.947 1.00 50.00  ? 269 LEU B CD1 1 
ATOM 2778 C CD2 . LEU B 2 269 ? 172.794 219.205 341.802 1.00 47.85  ? 269 LEU B CD2 1 
ATOM 2779 N N   . ARG B 2 270 ? 168.855 221.006 338.600 1.00 44.77  ? 270 ARG B N   1 
ATOM 2780 C CA  . ARG B 2 270 ? 167.746 220.538 337.788 1.00 46.94  ? 270 ARG B CA  1 
ATOM 2781 C C   . ARG B 2 270 ? 168.098 220.495 336.311 1.00 49.69  ? 270 ARG B C   1 
ATOM 2782 O O   . ARG B 2 270 ? 167.269 220.054 335.510 1.00 57.41  ? 270 ARG B O   1 
ATOM 2783 C CB  . ARG B 2 270 ? 166.506 221.416 337.994 1.00 48.30  ? 270 ARG B CB  1 
ATOM 2784 C CG  . ARG B 2 270 ? 166.690 222.873 337.625 1.00 52.78  ? 270 ARG B CG  1 
ATOM 2785 C CD  . ARG B 2 270 ? 165.346 223.548 337.468 1.00 48.52  ? 270 ARG B CD  1 
ATOM 2786 N NE  . ARG B 2 270 ? 164.633 223.046 336.301 1.00 42.24  ? 270 ARG B NE  1 
ATOM 2787 C CZ  . ARG B 2 270 ? 163.319 223.101 336.142 1.00 48.07  ? 270 ARG B CZ  1 
ATOM 2788 N NH1 . ARG B 2 270 ? 162.531 223.613 337.071 1.00 47.67  ? 270 ARG B NH1 1 
ATOM 2789 N NH2 . ARG B 2 270 ? 162.781 222.621 335.026 1.00 56.31  ? 270 ARG B NH2 1 
ATOM 2790 N N   . THR B 2 271 ? 169.290 220.936 335.928 1.00 52.26  ? 271 THR B N   1 
ATOM 2791 C CA  . THR B 2 271 ? 169.756 220.887 334.554 1.00 62.28  ? 271 THR B CA  1 
ATOM 2792 C C   . THR B 2 271 ? 171.060 220.130 334.402 1.00 61.51  ? 271 THR B C   1 
ATOM 2793 O O   . THR B 2 271 ? 171.285 219.515 333.358 1.00 65.31  ? 271 THR B O   1 
ATOM 2794 C CB  . THR B 2 271 ? 169.951 222.308 334.007 1.00 61.08  ? 271 THR B CB  1 
ATOM 2795 O OG1 . THR B 2 271 ? 168.792 223.096 334.298 1.00 61.83  ? 271 THR B OG1 1 
ATOM 2796 C CG2 . THR B 2 271 ? 170.174 222.276 332.505 1.00 61.29  ? 271 THR B CG2 1 
ATOM 2797 N N   . ASN B 2 272 ? 171.919 220.158 335.414 1.00 51.93  ? 272 ASN B N   1 
ATOM 2798 C CA  . ASN B 2 272 ? 173.187 219.450 335.380 1.00 56.29  ? 272 ASN B CA  1 
ATOM 2799 C C   . ASN B 2 272 ? 173.630 219.223 336.815 1.00 56.93  ? 272 ASN B C   1 
ATOM 2800 O O   . ASN B 2 272 ? 173.035 219.746 337.759 1.00 60.28  ? 272 ASN B O   1 
ATOM 2801 C CB  . ASN B 2 272 ? 174.244 220.230 334.598 1.00 60.80  ? 272 ASN B CB  1 
ATOM 2802 C CG  . ASN B 2 272 ? 174.434 221.633 335.126 1.00 61.15  ? 272 ASN B CG  1 
ATOM 2803 O OD1 . ASN B 2 272 ? 173.787 222.034 336.090 1.00 62.91  ? 272 ASN B OD1 1 
ATOM 2804 N ND2 . ASN B 2 272 ? 175.329 222.387 334.502 1.00 58.07  ? 272 ASN B ND2 1 
ATOM 2805 N N   . ASN B 2 273 ? 174.681 218.423 336.969 1.00 57.13  ? 273 ASN B N   1 
ATOM 2806 C CA  . ASN B 2 273 ? 175.267 218.198 338.282 1.00 51.65  ? 273 ASN B CA  1 
ATOM 2807 C C   . ASN B 2 273 ? 176.788 218.181 338.237 1.00 53.68  ? 273 ASN B C   1 
ATOM 2808 O O   . ASN B 2 273 ? 177.415 217.873 339.257 1.00 59.99  ? 273 ASN B O   1 
ATOM 2809 C CB  . ASN B 2 273 ? 174.746 216.890 338.879 1.00 54.17  ? 273 ASN B CB  1 
ATOM 2810 C CG  . ASN B 2 273 ? 174.874 215.724 337.925 1.00 64.75  ? 273 ASN B CG  1 
ATOM 2811 O OD1 . ASN B 2 273 ? 174.854 215.901 336.708 1.00 65.33  ? 273 ASN B OD1 1 
ATOM 2812 N ND2 . ASN B 2 273 ? 175.005 214.522 338.472 1.00 63.10  ? 273 ASN B ND2 1 
ATOM 2813 N N   . CYS B 2 274 ? 177.400 218.499 337.099 1.00 60.29  ? 274 CYS B N   1 
ATOM 2814 C CA  . CYS B 2 274 ? 178.847 218.555 336.974 1.00 65.71  ? 274 CYS B CA  1 
ATOM 2815 C C   . CYS B 2 274 ? 179.246 219.837 336.260 1.00 58.05  ? 274 CYS B C   1 
ATOM 2816 O O   . CYS B 2 274 ? 178.514 220.345 335.408 1.00 65.48  ? 274 CYS B O   1 
ATOM 2817 C CB  . CYS B 2 274 ? 179.394 217.349 336.206 1.00 65.46  ? 274 CYS B CB  1 
ATOM 2818 S SG  . CYS B 2 274 ? 178.995 217.351 334.444 1.00 83.54  ? 274 CYS B SG  1 
ATOM 2819 N N   . ALA B 2 275 ? 180.419 220.353 336.616 1.00 38.41  ? 275 ALA B N   1 
ATOM 2820 C CA  . ALA B 2 275 ? 180.960 221.556 336.000 1.00 46.05  ? 275 ALA B CA  1 
ATOM 2821 C C   . ALA B 2 275 ? 182.463 221.407 335.837 1.00 53.94  ? 275 ALA B C   1 
ATOM 2822 O O   . ALA B 2 275 ? 183.164 221.070 336.794 1.00 54.66  ? 275 ALA B O   1 
ATOM 2823 C CB  . ALA B 2 275 ? 180.641 222.799 336.833 1.00 49.75  ? 275 ALA B CB  1 
ATOM 2824 N N   . THR B 2 276 ? 182.951 221.672 334.630 1.00 50.56  ? 276 THR B N   1 
ATOM 2825 C CA  . THR B 2 276 ? 184.359 221.523 334.294 1.00 45.21  ? 276 THR B CA  1 
ATOM 2826 C C   . THR B 2 276 ? 184.959 222.881 333.967 1.00 48.08  ? 276 THR B C   1 
ATOM 2827 O O   . THR B 2 276 ? 184.453 223.594 333.094 1.00 53.61  ? 276 THR B O   1 
ATOM 2828 C CB  . THR B 2 276 ? 184.536 220.579 333.106 1.00 49.72  ? 276 THR B CB  1 
ATOM 2829 O OG1 . THR B 2 276 ? 183.942 219.310 333.407 1.00 56.39  ? 276 THR B OG1 1 
ATOM 2830 C CG2 . THR B 2 276 ? 186.008 220.389 332.791 1.00 56.08  ? 276 THR B CG2 1 
ATOM 2831 N N   . LEU B 2 277 ? 186.038 223.229 334.661 1.00 49.02  ? 277 LEU B N   1 
ATOM 2832 C CA  . LEU B 2 277 ? 186.797 224.446 334.409 1.00 45.40  ? 277 LEU B CA  1 
ATOM 2833 C C   . LEU B 2 277 ? 188.189 224.068 333.930 1.00 51.33  ? 277 LEU B C   1 
ATOM 2834 O O   . LEU B 2 277 ? 188.881 223.288 334.591 1.00 57.76  ? 277 LEU B O   1 
ATOM 2835 C CB  . LEU B 2 277 ? 186.900 225.300 335.672 1.00 45.54  ? 277 LEU B CB  1 
ATOM 2836 C CG  . LEU B 2 277 ? 185.588 225.784 336.277 1.00 48.36  ? 277 LEU B CG  1 
ATOM 2837 C CD1 . LEU B 2 277 ? 185.846 226.438 337.616 1.00 48.92  ? 277 LEU B CD1 1 
ATOM 2838 C CD2 . LEU B 2 277 ? 184.909 226.752 335.338 1.00 57.71  ? 277 LEU B CD2 1 
ATOM 2839 N N   . VAL B 2 278 ? 188.596 224.619 332.793 1.00 50.99  ? 278 VAL B N   1 
ATOM 2840 C CA  . VAL B 2 278 ? 189.930 224.383 332.242 1.00 50.56  ? 278 VAL B CA  1 
ATOM 2841 C C   . VAL B 2 278 ? 190.731 225.649 332.519 1.00 47.57  ? 278 VAL B C   1 
ATOM 2842 O O   . VAL B 2 278 ? 190.704 226.611 331.754 1.00 57.15  ? 278 VAL B O   1 
ATOM 2843 C CB  . VAL B 2 278 ? 189.885 224.039 330.757 1.00 50.01  ? 278 VAL B CB  1 
ATOM 2844 C CG1 . VAL B 2 278 ? 191.289 223.960 330.199 1.00 52.64  ? 278 VAL B CG1 1 
ATOM 2845 C CG2 . VAL B 2 278 ? 189.150 222.732 330.543 1.00 47.56  ? 278 VAL B CG2 1 
ATOM 2846 N N   . LEU B 2 279 ? 191.462 225.642 333.628 1.00 39.79  ? 279 LEU B N   1 
ATOM 2847 C CA  . LEU B 2 279 ? 192.198 226.816 334.065 1.00 49.31  ? 279 LEU B CA  1 
ATOM 2848 C C   . LEU B 2 279 ? 193.576 226.836 333.421 1.00 54.77  ? 279 LEU B C   1 
ATOM 2849 O O   . LEU B 2 279 ? 194.347 225.887 333.615 1.00 52.65  ? 279 LEU B O   1 
ATOM 2850 C CB  . LEU B 2 279 ? 192.337 226.820 335.573 1.00 50.60  ? 279 LEU B CB  1 
ATOM 2851 C CG  . LEU B 2 279 ? 191.030 226.630 336.332 1.00 47.84  ? 279 LEU B CG  1 
ATOM 2852 C CD1 . LEU B 2 279 ? 191.282 226.614 337.823 1.00 51.91  ? 279 LEU B CD1 1 
ATOM 2853 C CD2 . LEU B 2 279 ? 190.041 227.717 335.973 1.00 50.78  ? 279 LEU B CD2 1 
ATOM 2854 N N   . PRO B 2 280 ? 193.932 227.866 332.664 1.00 52.95  ? 280 PRO B N   1 
ATOM 2855 C CA  . PRO B 2 280 ? 195.301 227.989 332.165 1.00 53.62  ? 280 PRO B CA  1 
ATOM 2856 C C   . PRO B 2 280 ? 196.201 228.552 333.259 1.00 56.54  ? 280 PRO B C   1 
ATOM 2857 O O   . PRO B 2 280 ? 195.751 228.900 334.347 1.00 59.10  ? 280 PRO B O   1 
ATOM 2858 C CB  . PRO B 2 280 ? 195.154 228.955 330.995 1.00 47.48  ? 280 PRO B CB  1 
ATOM 2859 C CG  . PRO B 2 280 ? 194.042 229.832 331.404 1.00 52.17  ? 280 PRO B CG  1 
ATOM 2860 C CD  . PRO B 2 280 ? 193.085 228.969 332.179 1.00 51.89  ? 280 PRO B CD  1 
ATOM 2861 N N   . TYR B 2 281 ? 197.491 228.637 332.954 1.00 55.75  ? 281 TYR B N   1 
ATOM 2862 C CA  . TYR B 2 281 ? 198.450 229.187 333.903 1.00 44.64  ? 281 TYR B CA  1 
ATOM 2863 C C   . TYR B 2 281 ? 198.413 230.703 333.801 1.00 56.23  ? 281 TYR B C   1 
ATOM 2864 O O   . TYR B 2 281 ? 198.871 231.279 332.809 1.00 59.00  ? 281 TYR B O   1 
ATOM 2865 C CB  . TYR B 2 281 ? 199.852 228.656 333.635 1.00 49.86  ? 281 TYR B CB  1 
ATOM 2866 C CG  . TYR B 2 281 ? 200.872 229.182 334.614 1.00 53.78  ? 281 TYR B CG  1 
ATOM 2867 C CD1 . TYR B 2 281 ? 200.835 228.808 335.946 1.00 54.24  ? 281 TYR B CD1 1 
ATOM 2868 C CD2 . TYR B 2 281 ? 201.866 230.054 334.208 1.00 51.14  ? 281 TYR B CD2 1 
ATOM 2869 C CE1 . TYR B 2 281 ? 201.759 229.285 336.846 1.00 51.20  ? 281 TYR B CE1 1 
ATOM 2870 C CE2 . TYR B 2 281 ? 202.794 230.537 335.101 1.00 51.63  ? 281 TYR B CE2 1 
ATOM 2871 C CZ  . TYR B 2 281 ? 202.736 230.149 336.418 1.00 53.25  ? 281 TYR B CZ  1 
ATOM 2872 O OH  . TYR B 2 281 ? 203.660 230.627 337.314 1.00 59.53  ? 281 TYR B OH  1 
ATOM 2873 N N   . VAL B 2 282 ? 197.864 231.351 334.823 1.00 58.02  ? 282 VAL B N   1 
ATOM 2874 C CA  . VAL B 2 282 ? 197.738 232.801 334.870 1.00 49.63  ? 282 VAL B CA  1 
ATOM 2875 C C   . VAL B 2 282 ? 198.610 233.292 336.012 1.00 51.17  ? 282 VAL B C   1 
ATOM 2876 O O   . VAL B 2 282 ? 198.310 233.043 337.186 1.00 52.97  ? 282 VAL B O   1 
ATOM 2877 C CB  . VAL B 2 282 ? 196.281 233.243 335.050 1.00 47.21  ? 282 VAL B CB  1 
ATOM 2878 C CG1 . VAL B 2 282 ? 196.210 234.624 335.664 1.00 50.51  ? 282 VAL B CG1 1 
ATOM 2879 C CG2 . VAL B 2 282 ? 195.564 233.224 333.714 1.00 47.68  ? 282 VAL B CG2 1 
ATOM 2880 N N   . ASN B 2 283 ? 199.689 233.990 335.671 1.00 48.46  ? 283 ASN B N   1 
ATOM 2881 C CA  . ASN B 2 283 ? 200.599 234.532 336.665 1.00 45.83  ? 283 ASN B CA  1 
ATOM 2882 C C   . ASN B 2 283 ? 201.483 235.561 335.984 1.00 48.27  ? 283 ASN B C   1 
ATOM 2883 O O   . ASN B 2 283 ? 201.779 235.449 334.793 1.00 52.94  ? 283 ASN B O   1 
ATOM 2884 C CB  . ASN B 2 283 ? 201.446 233.435 337.311 1.00 41.05  ? 283 ASN B CB  1 
ATOM 2885 C CG  . ASN B 2 283 ? 202.368 233.969 338.380 1.00 52.21  ? 283 ASN B CG  1 
ATOM 2886 O OD1 . ASN B 2 283 ? 202.318 235.148 338.722 1.00 60.62  ? 283 ASN B OD1 1 
ATOM 2887 N ND2 . ASN B 2 283 ? 203.211 233.102 338.924 1.00 54.31  ? 283 ASN B ND2 1 
ATOM 2888 N N   . SER B 2 284 ? 201.899 236.568 336.754 1.00 45.01  ? 284 SER B N   1 
ATOM 2889 C CA  . SER B 2 284 ? 202.702 237.642 336.183 1.00 40.75  ? 284 SER B CA  1 
ATOM 2890 C C   . SER B 2 284 ? 204.017 237.122 335.624 1.00 47.77  ? 284 SER B C   1 
ATOM 2891 O O   . SER B 2 284 ? 204.586 237.730 334.712 1.00 47.09  ? 284 SER B O   1 
ATOM 2892 C CB  . SER B 2 284 ? 202.963 238.716 337.236 1.00 45.45  ? 284 SER B CB  1 
ATOM 2893 O OG  . SER B 2 284 ? 203.655 238.183 338.349 1.00 38.20  ? 284 SER B OG  1 
ATOM 2894 N N   . LEU B 2 285 ? 204.513 236.005 336.148 1.00 51.35  ? 285 LEU B N   1 
ATOM 2895 C CA  . LEU B 2 285 ? 205.780 235.423 335.732 1.00 42.71  ? 285 LEU B CA  1 
ATOM 2896 C C   . LEU B 2 285 ? 205.525 234.165 334.915 1.00 49.30  ? 285 LEU B C   1 
ATOM 2897 O O   . LEU B 2 285 ? 204.652 233.361 335.252 1.00 54.53  ? 285 LEU B O   1 
ATOM 2898 C CB  . LEU B 2 285 ? 206.646 235.090 336.945 1.00 42.83  ? 285 LEU B CB  1 
ATOM 2899 C CG  . LEU B 2 285 ? 206.879 236.266 337.888 1.00 48.28  ? 285 LEU B CG  1 
ATOM 2900 C CD1 . LEU B 2 285 ? 207.575 235.809 339.152 1.00 53.49  ? 285 LEU B CD1 1 
ATOM 2901 C CD2 . LEU B 2 285 ? 207.686 237.340 337.191 1.00 50.45  ? 285 LEU B CD2 1 
ATOM 2902 N N   . SER B 2 286 ? 206.295 233.995 333.842 1.00 57.74  ? 286 SER B N   1 
ATOM 2903 C CA  . SER B 2 286 ? 206.079 232.863 332.953 1.00 57.36  ? 286 SER B CA  1 
ATOM 2904 C C   . SER B 2 286 ? 206.228 231.528 333.668 1.00 61.43  ? 286 SER B C   1 
ATOM 2905 O O   . SER B 2 286 ? 205.708 230.518 333.184 1.00 61.31  ? 286 SER B O   1 
ATOM 2906 C CB  . SER B 2 286 ? 207.049 232.937 331.775 1.00 57.59  ? 286 SER B CB  1 
ATOM 2907 O OG  . SER B 2 286 ? 208.368 233.202 332.220 1.00 67.10  ? 286 SER B OG  1 
ATOM 2908 N N   . ILE B 2 287 ? 206.929 231.495 334.799 1.00 59.47  ? 287 ILE B N   1 
ATOM 2909 C CA  . ILE B 2 287 ? 207.078 230.272 335.580 1.00 58.57  ? 287 ILE B CA  1 
ATOM 2910 C C   . ILE B 2 287 ? 207.452 230.662 337.002 1.00 60.54  ? 287 ILE B C   1 
ATOM 2911 O O   . ILE B 2 287 ? 208.340 231.492 337.213 1.00 68.91  ? 287 ILE B O   1 
ATOM 2912 C CB  . ILE B 2 287 ? 208.129 229.339 334.955 1.00 61.98  ? 287 ILE B CB  1 
ATOM 2913 C CG1 . ILE B 2 287 ? 208.019 227.939 335.553 1.00 59.83  ? 287 ILE B CG1 1 
ATOM 2914 C CG2 . ILE B 2 287 ? 209.521 229.889 335.172 1.00 64.27  ? 287 ILE B CG2 1 
ATOM 2915 C CD1 . ILE B 2 287 ? 208.982 226.945 334.951 1.00 59.72  ? 287 ILE B CD1 1 
ATOM 2916 N N   . ASP B 2 288 ? 206.784 230.067 337.988 1.00 63.45  ? 288 ASP B N   1 
ATOM 2917 C CA  . ASP B 2 288 ? 206.914 230.498 339.371 1.00 68.20  ? 288 ASP B CA  1 
ATOM 2918 C C   . ASP B 2 288 ? 207.025 229.283 340.279 1.00 70.82  ? 288 ASP B C   1 
ATOM 2919 O O   . ASP B 2 288 ? 206.661 228.166 339.906 1.00 71.29  ? 288 ASP B O   1 
ATOM 2920 C CB  . ASP B 2 288 ? 205.723 231.365 339.794 1.00 73.85  ? 288 ASP B CB  1 
ATOM 2921 C CG  . ASP B 2 288 ? 205.975 232.115 341.084 1.00 76.73  ? 288 ASP B CG  1 
ATOM 2922 O OD1 . ASP B 2 288 ? 206.829 231.670 341.878 1.00 73.07  ? 288 ASP B OD1 1 
ATOM 2923 O OD2 . ASP B 2 288 ? 205.315 233.151 341.303 1.00 73.22  ? 288 ASP B OD2 1 
ATOM 2924 N N   . SER B 2 289 ? 207.538 229.517 341.486 1.00 75.24  ? 289 SER B N   1 
ATOM 2925 C CA  . SER B 2 289 ? 207.700 228.447 342.461 1.00 75.60  ? 289 SER B CA  1 
ATOM 2926 C C   . SER B 2 289 ? 206.338 228.034 343.004 1.00 77.23  ? 289 SER B C   1 
ATOM 2927 O O   . SER B 2 289 ? 205.613 228.855 343.575 1.00 74.55  ? 289 SER B O   1 
ATOM 2928 C CB  . SER B 2 289 ? 208.616 228.900 343.594 1.00 70.15  ? 289 SER B CB  1 
ATOM 2929 O OG  . SER B 2 289 ? 208.034 229.965 344.322 1.00 72.25  ? 289 SER B OG  1 
ATOM 2930 N N   . MET B 2 290 ? 205.999 226.756 342.838 1.00 75.62  ? 290 MET B N   1 
ATOM 2931 C CA  . MET B 2 290 ? 204.668 226.266 343.166 1.00 72.39  ? 290 MET B CA  1 
ATOM 2932 C C   . MET B 2 290 ? 204.421 226.158 344.664 1.00 72.92  ? 290 MET B C   1 
ATOM 2933 O O   . MET B 2 290 ? 203.272 225.953 345.068 1.00 76.35  ? 290 MET B O   1 
ATOM 2934 C CB  . MET B 2 290 ? 204.454 224.899 342.517 1.00 74.56  ? 290 MET B CB  1 
ATOM 2935 C CG  . MET B 2 290 ? 204.613 224.893 341.007 1.00 74.66  ? 290 MET B CG  1 
ATOM 2936 S SD  . MET B 2 290 ? 203.102 225.330 340.134 1.00 81.89  ? 290 MET B SD  1 
ATOM 2937 C CE  . MET B 2 290 ? 202.222 223.775 340.201 1.00 78.90  ? 290 MET B CE  1 
ATOM 2938 N N   . VAL B 2 291 ? 205.458 226.285 345.499 1.00 67.66  ? 291 VAL B N   1 
ATOM 2939 C CA  . VAL B 2 291 ? 205.301 226.081 346.935 1.00 70.06  ? 291 VAL B CA  1 
ATOM 2940 C C   . VAL B 2 291 ? 205.023 227.374 347.684 1.00 72.69  ? 291 VAL B C   1 
ATOM 2941 O O   . VAL B 2 291 ? 204.844 227.343 348.909 1.00 71.03  ? 291 VAL B O   1 
ATOM 2942 C CB  . VAL B 2 291 ? 206.557 225.410 347.528 1.00 72.66  ? 291 VAL B CB  1 
ATOM 2943 C CG1 . VAL B 2 291 ? 206.282 224.899 348.934 1.00 72.91  ? 291 VAL B CG1 1 
ATOM 2944 C CG2 . VAL B 2 291 ? 207.033 224.285 346.629 1.00 77.56  ? 291 VAL B CG2 1 
ATOM 2945 N N   . LYS B 2 292 ? 204.974 228.510 346.992 1.00 79.09  ? 292 LYS B N   1 
ATOM 2946 C CA  . LYS B 2 292 ? 204.867 229.798 347.664 1.00 77.55  ? 292 LYS B CA  1 
ATOM 2947 C C   . LYS B 2 292 ? 203.703 230.613 347.116 1.00 76.44  ? 292 LYS B C   1 
ATOM 2948 O O   . LYS B 2 292 ? 203.065 231.367 347.856 1.00 74.03  ? 292 LYS B O   1 
ATOM 2949 C CB  . LYS B 2 292 ? 206.176 230.577 347.511 1.00 73.12  ? 292 LYS B CB  1 
ATOM 2950 C CG  . LYS B 2 292 ? 207.421 229.695 347.514 1.00 77.14  ? 292 LYS B CG  1 
ATOM 2951 C CD  . LYS B 2 292 ? 208.695 230.509 347.377 1.00 78.68  ? 292 LYS B CD  1 
ATOM 2952 C CE  . LYS B 2 292 ? 209.029 231.247 348.660 1.00 78.62  ? 292 LYS B CE  1 
ATOM 2953 N NZ  . LYS B 2 292 ? 210.313 231.993 348.558 1.00 76.30  ? 292 LYS B NZ  1 
ATOM 2954 N N   . HIS B 2 293 ? 203.417 230.463 345.826 1.00 70.75  ? 293 HIS B N   1 
ATOM 2955 C CA  . HIS B 2 293 ? 202.442 231.287 345.127 1.00 69.26  ? 293 HIS B CA  1 
ATOM 2956 C C   . HIS B 2 293 ? 201.296 230.416 344.632 1.00 75.05  ? 293 HIS B C   1 
ATOM 2957 O O   . HIS B 2 293 ? 201.525 229.419 343.940 1.00 74.31  ? 293 HIS B O   1 
ATOM 2958 C CB  . HIS B 2 293 ? 203.102 232.010 343.953 1.00 66.30  ? 293 HIS B CB  1 
ATOM 2959 C CG  . HIS B 2 293 ? 202.232 233.041 343.309 1.00 66.12  ? 293 HIS B CG  1 
ATOM 2960 N ND1 . HIS B 2 293 ? 202.315 233.351 341.969 1.00 69.92  ? 293 HIS B ND1 1 
ATOM 2961 C CD2 . HIS B 2 293 ? 201.269 233.841 343.821 1.00 67.98  ? 293 HIS B CD2 1 
ATOM 2962 C CE1 . HIS B 2 293 ? 201.436 234.293 341.683 1.00 70.40  ? 293 HIS B CE1 1 
ATOM 2963 N NE2 . HIS B 2 293 ? 200.788 234.608 342.789 1.00 67.71  ? 293 HIS B NE2 1 
ATOM 2964 N N   . ASN B 2 294 ? 200.068 230.799 344.979 1.00 72.73  ? 294 ASN B N   1 
ATOM 2965 C CA  . ASN B 2 294 ? 198.861 230.076 344.579 1.00 63.42  ? 294 ASN B CA  1 
ATOM 2966 C C   . ASN B 2 294 ? 198.223 230.822 343.413 1.00 61.31  ? 294 ASN B C   1 
ATOM 2967 O O   . ASN B 2 294 ? 197.578 231.854 343.602 1.00 67.04  ? 294 ASN B O   1 
ATOM 2968 C CB  . ASN B 2 294 ? 197.897 229.950 345.751 1.00 62.80  ? 294 ASN B CB  1 
ATOM 2969 C CG  . ASN B 2 294 ? 198.495 229.197 346.916 1.00 67.16  ? 294 ASN B CG  1 
ATOM 2970 O OD1 . ASN B 2 294 ? 199.687 228.900 346.929 1.00 65.18  ? 294 ASN B OD1 1 
ATOM 2971 N ND2 . ASN B 2 294 ? 197.670 228.889 347.906 1.00 69.38  ? 294 ASN B ND2 1 
ATOM 2972 N N   . ASN B 2 295 ? 198.392 230.284 342.204 1.00 60.13  ? 295 ASN B N   1 
ATOM 2973 C CA  . ASN B 2 295 ? 197.927 230.983 341.012 1.00 59.60  ? 295 ASN B CA  1 
ATOM 2974 C C   . ASN B 2 295 ? 196.418 231.184 341.040 1.00 63.46  ? 295 ASN B C   1 
ATOM 2975 O O   . ASN B 2 295 ? 195.926 232.305 340.874 1.00 68.20  ? 295 ASN B O   1 
ATOM 2976 C CB  . ASN B 2 295 ? 198.333 230.208 339.759 1.00 56.88  ? 295 ASN B CB  1 
ATOM 2977 C CG  . ASN B 2 295 ? 199.807 229.889 339.726 1.00 68.75  ? 295 ASN B CG  1 
ATOM 2978 O OD1 . ASN B 2 295 ? 200.202 228.758 339.449 1.00 69.15  ? 295 ASN B OD1 1 
ATOM 2979 N ND2 . ASN B 2 295 ? 200.633 230.884 340.015 1.00 71.88  ? 295 ASN B ND2 1 
ATOM 2980 N N   . TRP B 2 296 ? 195.668 230.109 341.255 1.00 55.06  ? 296 TRP B N   1 
ATOM 2981 C CA  . TRP B 2 296 ? 194.220 230.117 341.148 1.00 45.92  ? 296 TRP B CA  1 
ATOM 2982 C C   . TRP B 2 296 ? 193.580 229.945 342.522 1.00 45.13  ? 296 TRP B C   1 
ATOM 2983 O O   . TRP B 2 296 ? 194.252 229.950 343.557 1.00 52.39  ? 296 TRP B O   1 
ATOM 2984 C CB  . TRP B 2 296 ? 193.763 229.020 340.188 1.00 41.65  ? 296 TRP B CB  1 
ATOM 2985 C CG  . TRP B 2 296 ? 194.041 229.309 338.756 1.00 48.43  ? 296 TRP B CG  1 
ATOM 2986 C CD1 . TRP B 2 296 ? 195.079 228.837 338.013 1.00 55.28  ? 296 TRP B CD1 1 
ATOM 2987 C CD2 . TRP B 2 296 ? 193.263 230.129 337.882 1.00 46.32  ? 296 TRP B CD2 1 
ATOM 2988 N NE1 . TRP B 2 296 ? 194.997 229.313 336.730 1.00 52.29  ? 296 TRP B NE1 1 
ATOM 2989 C CE2 . TRP B 2 296 ? 193.890 230.111 336.624 1.00 48.12  ? 296 TRP B CE2 1 
ATOM 2990 C CE3 . TRP B 2 296 ? 192.097 230.880 338.041 1.00 49.40  ? 296 TRP B CE3 1 
ATOM 2991 C CZ2 . TRP B 2 296 ? 193.391 230.814 335.534 1.00 49.72  ? 296 TRP B CZ2 1 
ATOM 2992 C CZ3 . TRP B 2 296 ? 191.604 231.575 336.959 1.00 50.02  ? 296 TRP B CZ3 1 
ATOM 2993 C CH2 . TRP B 2 296 ? 192.249 231.538 335.721 1.00 49.11  ? 296 TRP B CH2 1 
ATOM 2994 N N   . GLY B 2 297 ? 192.261 229.807 342.522 1.00 45.28  ? 297 GLY B N   1 
ATOM 2995 C CA  . GLY B 2 297 ? 191.504 229.514 343.719 1.00 52.81  ? 297 GLY B CA  1 
ATOM 2996 C C   . GLY B 2 297 ? 190.094 229.117 343.342 1.00 60.76  ? 297 GLY B C   1 
ATOM 2997 O O   . GLY B 2 297 ? 189.446 229.812 342.555 1.00 65.38  ? 297 GLY B O   1 
ATOM 2998 N N   . ILE B 2 298 ? 189.605 228.006 343.877 1.00 48.48  ? 298 ILE B N   1 
ATOM 2999 C CA  . ILE B 2 298 ? 188.293 227.480 343.529 1.00 39.78  ? 298 ILE B CA  1 
ATOM 3000 C C   . ILE B 2 298 ? 187.369 227.747 344.704 1.00 42.60  ? 298 ILE B C   1 
ATOM 3001 O O   . ILE B 2 298 ? 187.536 227.166 345.782 1.00 53.94  ? 298 ILE B O   1 
ATOM 3002 C CB  . ILE B 2 298 ? 188.348 225.984 343.202 1.00 47.74  ? 298 ILE B CB  1 
ATOM 3003 C CG1 . ILE B 2 298 ? 189.530 225.681 342.281 1.00 44.09  ? 298 ILE B CG1 1 
ATOM 3004 C CG2 . ILE B 2 298 ? 187.048 225.540 342.563 1.00 47.35  ? 298 ILE B CG2 1 
ATOM 3005 C CD1 . ILE B 2 298 ? 189.533 226.474 341.000 1.00 44.08  ? 298 ILE B CD1 1 
ATOM 3006 N N   . ALA B 2 299 ? 186.390 228.618 344.503 1.00 41.30  ? 299 ALA B N   1 
ATOM 3007 C CA  . ALA B 2 299 ? 185.398 228.931 345.522 1.00 47.58  ? 299 ALA B CA  1 
ATOM 3008 C C   . ALA B 2 299 ? 184.054 228.388 345.066 1.00 56.67  ? 299 ALA B C   1 
ATOM 3009 O O   . ALA B 2 299 ? 183.563 228.759 343.996 1.00 61.59  ? 299 ALA B O   1 
ATOM 3010 C CB  . ALA B 2 299 ? 185.320 230.435 345.769 1.00 52.77  ? 299 ALA B CB  1 
ATOM 3011 N N   . ILE B 2 300 ? 183.468 227.510 345.871 1.00 51.37  ? 300 ILE B N   1 
ATOM 3012 C CA  . ILE B 2 300 ? 182.154 226.941 345.613 1.00 38.66  ? 300 ILE B CA  1 
ATOM 3013 C C   . ILE B 2 300 ? 181.196 227.561 346.616 1.00 49.18  ? 300 ILE B C   1 
ATOM 3014 O O   . ILE B 2 300 ? 181.403 227.449 347.832 1.00 53.34  ? 300 ILE B O   1 
ATOM 3015 C CB  . ILE B 2 300 ? 182.170 225.410 345.722 1.00 43.30  ? 300 ILE B CB  1 
ATOM 3016 C CG1 . ILE B 2 300 ? 182.892 224.815 344.513 1.00 45.55  ? 300 ILE B CG1 1 
ATOM 3017 C CG2 . ILE B 2 300 ? 180.757 224.870 345.831 1.00 53.08  ? 300 ILE B CG2 1 
ATOM 3018 C CD1 . ILE B 2 300 ? 183.046 223.317 344.565 1.00 50.95  ? 300 ILE B CD1 1 
ATOM 3019 N N   . LEU B 2 301 ? 180.155 228.218 346.106 1.00 51.32  ? 301 LEU B N   1 
ATOM 3020 C CA  . LEU B 2 301 ? 179.211 228.950 346.938 1.00 49.15  ? 301 LEU B CA  1 
ATOM 3021 C C   . LEU B 2 301 ? 177.787 228.525 346.600 1.00 54.93  ? 301 LEU B C   1 
ATOM 3022 O O   . LEU B 2 301 ? 177.427 228.473 345.414 1.00 55.31  ? 301 LEU B O   1 
ATOM 3023 C CB  . LEU B 2 301 ? 179.366 230.460 346.737 1.00 49.60  ? 301 LEU B CB  1 
ATOM 3024 C CG  . LEU B 2 301 ? 180.333 231.181 347.675 1.00 57.14  ? 301 LEU B CG  1 
ATOM 3025 C CD1 . LEU B 2 301 ? 181.727 230.607 347.562 1.00 63.91  ? 301 LEU B CD1 1 
ATOM 3026 C CD2 . LEU B 2 301 ? 180.343 232.664 347.372 1.00 52.02  ? 301 LEU B CD2 1 
ATOM 3027 N N   . PRO B 2 302 ? 176.943 228.224 347.591 1.00 51.54  ? 302 PRO B N   1 
ATOM 3028 C CA  . PRO B 2 302 ? 175.536 227.941 347.282 1.00 43.42  ? 302 PRO B CA  1 
ATOM 3029 C C   . PRO B 2 302 ? 174.761 229.193 346.906 1.00 44.94  ? 302 PRO B C   1 
ATOM 3030 O O   . PRO B 2 302 ? 174.432 230.006 347.774 1.00 47.99  ? 302 PRO B O   1 
ATOM 3031 C CB  . PRO B 2 302 ? 175.002 227.328 348.584 1.00 45.26  ? 302 PRO B CB  1 
ATOM 3032 C CG  . PRO B 2 302 ? 176.198 226.974 349.382 1.00 47.53  ? 302 PRO B CG  1 
ATOM 3033 C CD  . PRO B 2 302 ? 177.245 227.955 349.004 1.00 51.46  ? 302 PRO B CD  1 
ATOM 3034 N N   . LEU B 2 303 ? 174.453 229.359 345.620 1.00 45.13  ? 303 LEU B N   1 
ATOM 3035 C CA  . LEU B 2 303 ? 173.640 230.496 345.207 1.00 42.19  ? 303 LEU B CA  1 
ATOM 3036 C C   . LEU B 2 303 ? 172.225 230.372 345.753 1.00 49.41  ? 303 LEU B C   1 
ATOM 3037 O O   . LEU B 2 303 ? 171.690 231.317 346.342 1.00 50.81  ? 303 LEU B O   1 
ATOM 3038 C CB  . LEU B 2 303 ? 173.619 230.602 343.683 1.00 38.38  ? 303 LEU B CB  1 
ATOM 3039 C CG  . LEU B 2 303 ? 174.965 230.792 342.987 1.00 40.33  ? 303 LEU B CG  1 
ATOM 3040 C CD1 . LEU B 2 303 ? 174.769 230.840 341.486 1.00 36.81  ? 303 LEU B CD1 1 
ATOM 3041 C CD2 . LEU B 2 303 ? 175.656 232.048 343.475 1.00 44.24  ? 303 LEU B CD2 1 
ATOM 3042 N N   . ALA B 2 304 ? 171.606 229.208 345.568 1.00 46.41  ? 304 ALA B N   1 
ATOM 3043 C CA  . ALA B 2 304 ? 170.287 228.910 346.110 1.00 37.85  ? 304 ALA B CA  1 
ATOM 3044 C C   . ALA B 2 304 ? 170.417 227.753 347.090 1.00 45.26  ? 304 ALA B C   1 
ATOM 3045 O O   . ALA B 2 304 ? 170.892 226.673 346.699 1.00 47.41  ? 304 ALA B O   1 
ATOM 3046 C CB  . ALA B 2 304 ? 169.301 228.562 344.997 1.00 40.06  ? 304 ALA B CB  1 
ATOM 3047 N N   . PRO B 2 305 ? 170.011 227.905 348.348 1.00 45.58  ? 305 PRO B N   1 
ATOM 3048 C CA  . PRO B 2 305 ? 170.299 226.865 349.340 1.00 45.89  ? 305 PRO B CA  1 
ATOM 3049 C C   . PRO B 2 305 ? 169.664 225.534 348.970 1.00 45.78  ? 305 PRO B C   1 
ATOM 3050 O O   . PRO B 2 305 ? 168.625 225.475 348.312 1.00 48.13  ? 305 PRO B O   1 
ATOM 3051 C CB  . PRO B 2 305 ? 169.702 227.430 350.632 1.00 44.49  ? 305 PRO B CB  1 
ATOM 3052 C CG  . PRO B 2 305 ? 168.663 228.383 350.181 1.00 46.01  ? 305 PRO B CG  1 
ATOM 3053 C CD  . PRO B 2 305 ? 169.187 228.984 348.915 1.00 40.82  ? 305 PRO B CD  1 
ATOM 3054 N N   . LEU B 2 306 ? 170.316 224.457 349.401 1.00 49.35  ? 306 LEU B N   1 
ATOM 3055 C CA  . LEU B 2 306 ? 169.810 223.119 349.136 1.00 49.53  ? 306 LEU B CA  1 
ATOM 3056 C C   . LEU B 2 306 ? 168.458 222.916 349.803 1.00 51.24  ? 306 LEU B C   1 
ATOM 3057 O O   . LEU B 2 306 ? 168.217 223.388 350.917 1.00 53.42  ? 306 LEU B O   1 
ATOM 3058 C CB  . LEU B 2 306 ? 170.798 222.072 349.647 1.00 48.43  ? 306 LEU B CB  1 
ATOM 3059 C CG  . LEU B 2 306 ? 170.422 220.613 349.397 1.00 46.88  ? 306 LEU B CG  1 
ATOM 3060 C CD1 . LEU B 2 306 ? 170.637 220.259 347.944 1.00 52.57  ? 306 LEU B CD1 1 
ATOM 3061 C CD2 . LEU B 2 306 ? 171.217 219.693 350.296 1.00 45.39  ? 306 LEU B CD2 1 
ATOM 3062 N N   . ASN B 2 307 ? 167.572 222.206 349.111 1.00 51.85  ? 307 ASN B N   1 
ATOM 3063 C CA  . ASN B 2 307 ? 166.317 221.768 349.698 1.00 54.78  ? 307 ASN B CA  1 
ATOM 3064 C C   . ASN B 2 307 ? 165.900 220.481 349.006 1.00 56.19  ? 307 ASN B C   1 
ATOM 3065 O O   . ASN B 2 307 ? 166.342 220.183 347.894 1.00 58.61  ? 307 ASN B O   1 
ATOM 3066 C CB  . ASN B 2 307 ? 165.232 222.837 349.578 1.00 51.81  ? 307 ASN B CB  1 
ATOM 3067 C CG  . ASN B 2 307 ? 164.163 222.695 350.632 1.00 54.97  ? 307 ASN B CG  1 
ATOM 3068 O OD1 . ASN B 2 307 ? 164.248 221.833 351.505 1.00 56.61  ? 307 ASN B OD1 1 
ATOM 3069 N ND2 . ASN B 2 307 ? 163.153 223.551 350.568 1.00 58.21  ? 307 ASN B ND2 1 
ATOM 3070 N N   . PHE B 2 308 ? 165.046 219.714 349.676 1.00 56.84  ? 308 PHE B N   1 
ATOM 3071 C CA  . PHE B 2 308 ? 164.756 218.364 349.217 1.00 59.45  ? 308 PHE B CA  1 
ATOM 3072 C C   . PHE B 2 308 ? 163.415 217.906 349.767 1.00 58.57  ? 308 PHE B C   1 
ATOM 3073 O O   . PHE B 2 308 ? 162.866 218.501 350.698 1.00 56.25  ? 308 PHE B O   1 
ATOM 3074 C CB  . PHE B 2 308 ? 165.866 217.403 349.642 1.00 54.56  ? 308 PHE B CB  1 
ATOM 3075 C CG  . PHE B 2 308 ? 166.303 217.585 351.062 1.00 50.59  ? 308 PHE B CG  1 
ATOM 3076 C CD1 . PHE B 2 308 ? 165.511 217.147 352.104 1.00 55.18  ? 308 PHE B CD1 1 
ATOM 3077 C CD2 . PHE B 2 308 ? 167.500 218.205 351.355 1.00 57.80  ? 308 PHE B CD2 1 
ATOM 3078 C CE1 . PHE B 2 308 ? 165.906 217.319 353.410 1.00 54.48  ? 308 PHE B CE1 1 
ATOM 3079 C CE2 . PHE B 2 308 ? 167.900 218.380 352.660 1.00 62.08  ? 308 PHE B CE2 1 
ATOM 3080 C CZ  . PHE B 2 308 ? 167.102 217.935 353.689 1.00 58.76  ? 308 PHE B CZ  1 
ATOM 3081 N N   . ALA B 2 309 ? 162.897 216.834 349.176 1.00 55.77  ? 309 ALA B N   1 
ATOM 3082 C CA  . ALA B 2 309 ? 161.666 216.228 349.657 1.00 58.22  ? 309 ALA B CA  1 
ATOM 3083 C C   . ALA B 2 309 ? 161.907 215.510 350.979 1.00 57.19  ? 309 ALA B C   1 
ATOM 3084 O O   . ALA B 2 309 ? 163.013 215.052 351.272 1.00 60.99  ? 309 ALA B O   1 
ATOM 3085 C CB  . ALA B 2 309 ? 161.114 215.249 348.623 1.00 57.89  ? 309 ALA B CB  1 
ATOM 3086 N N   . SER B 2 310 ? 160.848 215.403 351.778 1.00 56.96  ? 310 SER B N   1 
ATOM 3087 C CA  . SER B 2 310 ? 160.982 214.866 353.125 1.00 60.81  ? 310 SER B CA  1 
ATOM 3088 C C   . SER B 2 310 ? 161.496 213.433 353.092 1.00 66.04  ? 310 SER B C   1 
ATOM 3089 O O   . SER B 2 310 ? 161.109 212.634 352.236 1.00 64.60  ? 310 SER B O   1 
ATOM 3090 C CB  . SER B 2 310 ? 159.640 214.913 353.850 1.00 63.25  ? 310 SER B CB  1 
ATOM 3091 O OG  . SER B 2 310 ? 158.789 213.874 353.402 1.00 65.00  ? 310 SER B OG  1 
ATOM 3092 N N   . GLU B 2 311 ? 162.369 213.112 354.044 1.00 71.80  ? 311 GLU B N   1 
ATOM 3093 C CA  . GLU B 2 311 ? 162.975 211.802 354.266 1.00 67.76  ? 311 GLU B CA  1 
ATOM 3094 C C   . GLU B 2 311 ? 164.077 211.505 353.254 1.00 67.04  ? 311 GLU B C   1 
ATOM 3095 O O   . GLU B 2 311 ? 164.732 210.465 353.372 1.00 66.16  ? 311 GLU B O   1 
ATOM 3096 C CB  . GLU B 2 311 ? 161.948 210.661 354.232 1.00 64.21  ? 311 GLU B CB  1 
ATOM 3097 C CG  . GLU B 2 311 ? 162.461 209.357 354.821 1.00 68.08  ? 311 GLU B CG  1 
ATOM 3098 C CD  . GLU B 2 311 ? 161.371 208.319 354.989 1.00 74.69  ? 311 GLU B CD  1 
ATOM 3099 O OE1 . GLU B 2 311 ? 160.204 208.623 354.665 1.00 75.54  ? 311 GLU B OE1 1 
ATOM 3100 O OE2 . GLU B 2 311 ? 161.681 207.199 355.443 1.00 70.49  ? 311 GLU B OE2 1 
ATOM 3101 N N   . SER B 2 312 ? 164.310 212.370 352.274 1.00 58.12  ? 312 SER B N   1 
ATOM 3102 C CA  . SER B 2 312 ? 165.428 212.171 351.371 1.00 55.27  ? 312 SER B CA  1 
ATOM 3103 C C   . SER B 2 312 ? 166.741 212.424 352.108 1.00 59.67  ? 312 SER B C   1 
ATOM 3104 O O   . SER B 2 312 ? 166.769 212.966 353.216 1.00 61.58  ? 312 SER B O   1 
ATOM 3105 C CB  . SER B 2 312 ? 165.305 213.092 350.161 1.00 52.83  ? 312 SER B CB  1 
ATOM 3106 O OG  . SER B 2 312 ? 165.253 214.443 350.567 1.00 62.20  ? 312 SER B OG  1 
ATOM 3107 N N   . SER B 2 313 ? 167.840 212.019 351.484 1.00 56.16  ? 313 SER B N   1 
ATOM 3108 C CA  . SER B 2 313 ? 169.142 212.174 352.113 1.00 51.39  ? 313 SER B CA  1 
ATOM 3109 C C   . SER B 2 313 ? 169.417 213.655 352.353 1.00 58.90  ? 313 SER B C   1 
ATOM 3110 O O   . SER B 2 313 ? 169.291 214.459 351.421 1.00 61.75  ? 313 SER B O   1 
ATOM 3111 C CB  . SER B 2 313 ? 170.235 211.574 351.237 1.00 54.85  ? 313 SER B CB  1 
ATOM 3112 O OG  . SER B 2 313 ? 170.421 212.354 350.075 1.00 60.17  ? 313 SER B OG  1 
ATOM 3113 N N   . PRO B 2 314 ? 169.797 214.057 353.566 1.00 57.04  ? 314 PRO B N   1 
ATOM 3114 C CA  . PRO B 2 314 ? 169.876 215.486 353.893 1.00 57.89  ? 314 PRO B CA  1 
ATOM 3115 C C   . PRO B 2 314 ? 171.188 216.174 353.549 1.00 52.14  ? 314 PRO B C   1 
ATOM 3116 O O   . PRO B 2 314 ? 171.310 217.375 353.812 1.00 56.59  ? 314 PRO B O   1 
ATOM 3117 C CB  . PRO B 2 314 ? 169.664 215.475 355.410 1.00 55.79  ? 314 PRO B CB  1 
ATOM 3118 C CG  . PRO B 2 314 ? 170.303 214.215 355.847 1.00 57.06  ? 314 PRO B CG  1 
ATOM 3119 C CD  . PRO B 2 314 ? 170.086 213.217 354.741 1.00 51.84  ? 314 PRO B CD  1 
ATOM 3120 N N   . GLU B 2 315 ? 172.167 215.471 352.986 1.00 47.04  ? 315 GLU B N   1 
ATOM 3121 C CA  . GLU B 2 315 ? 173.464 216.074 352.688 1.00 51.39  ? 315 GLU B CA  1 
ATOM 3122 C C   . GLU B 2 315 ? 174.004 215.410 351.433 1.00 49.87  ? 315 GLU B C   1 
ATOM 3123 O O   . GLU B 2 315 ? 174.303 214.213 351.454 1.00 54.62  ? 315 GLU B O   1 
ATOM 3124 C CB  . GLU B 2 315 ? 174.433 215.897 353.852 1.00 54.73  ? 315 GLU B CB  1 
ATOM 3125 C CG  . GLU B 2 315 ? 173.865 216.278 355.206 1.00 61.05  ? 315 GLU B CG  1 
ATOM 3126 C CD  . GLU B 2 315 ? 174.864 216.084 356.328 1.00 65.61  ? 315 GLU B CD  1 
ATOM 3127 O OE1 . GLU B 2 315 ? 176.019 215.711 356.037 1.00 61.36  ? 315 GLU B OE1 1 
ATOM 3128 O OE2 . GLU B 2 315 ? 174.493 216.300 357.501 1.00 65.49  ? 315 GLU B OE2 1 
ATOM 3129 N N   . ILE B 2 316 ? 174.144 216.168 350.356 1.00 46.56  ? 316 ILE B N   1 
ATOM 3130 C CA  . ILE B 2 316 ? 174.575 215.626 349.068 1.00 50.37  ? 316 ILE B CA  1 
ATOM 3131 C C   . ILE B 2 316 ? 176.065 215.900 348.905 1.00 49.21  ? 316 ILE B C   1 
ATOM 3132 O O   . ILE B 2 316 ? 176.509 217.014 349.201 1.00 58.14  ? 316 ILE B O   1 
ATOM 3133 C CB  . ILE B 2 316 ? 173.775 216.220 347.894 1.00 48.65  ? 316 ILE B CB  1 
ATOM 3134 C CG1 . ILE B 2 316 ? 174.058 217.709 347.726 1.00 54.26  ? 316 ILE B CG1 1 
ATOM 3135 C CG2 . ILE B 2 316 ? 172.293 215.991 348.108 1.00 48.94  ? 316 ILE B CG2 1 
ATOM 3136 C CD1 . ILE B 2 316 ? 173.242 218.341 346.629 1.00 55.41  ? 316 ILE B CD1 1 
ATOM 3137 N N   . PRO B 2 317 ? 176.859 214.932 348.465 1.00 47.31  ? 317 PRO B N   1 
ATOM 3138 C CA  . PRO B 2 317 ? 178.302 215.153 348.371 1.00 47.67  ? 317 PRO B CA  1 
ATOM 3139 C C   . PRO B 2 317 ? 178.695 215.949 347.139 1.00 55.04  ? 317 PRO B C   1 
ATOM 3140 O O   . PRO B 2 317 ? 178.011 215.943 346.114 1.00 64.27  ? 317 PRO B O   1 
ATOM 3141 C CB  . PRO B 2 317 ? 178.862 213.729 348.305 1.00 55.21  ? 317 PRO B CB  1 
ATOM 3142 C CG  . PRO B 2 317 ? 177.791 212.956 347.642 1.00 49.73  ? 317 PRO B CG  1 
ATOM 3143 C CD  . PRO B 2 317 ? 176.494 213.553 348.098 1.00 44.92  ? 317 PRO B CD  1 
ATOM 3144 N N   . ILE B 2 318 ? 179.825 216.642 347.259 1.00 53.37  ? 318 ILE B N   1 
ATOM 3145 C CA  . ILE B 2 318 ? 180.463 217.343 346.153 1.00 53.71  ? 318 ILE B CA  1 
ATOM 3146 C C   . ILE B 2 318 ? 181.900 216.858 346.081 1.00 50.98  ? 318 ILE B C   1 
ATOM 3147 O O   . ILE B 2 318 ? 182.606 216.857 347.095 1.00 60.07  ? 318 ILE B O   1 
ATOM 3148 C CB  . ILE B 2 318 ? 180.427 218.872 346.336 1.00 49.65  ? 318 ILE B CB  1 
ATOM 3149 C CG1 . ILE B 2 318 ? 179.003 219.350 346.608 1.00 52.03  ? 318 ILE B CG1 1 
ATOM 3150 C CG2 . ILE B 2 318 ? 180.979 219.565 345.102 1.00 52.15  ? 318 ILE B CG2 1 
ATOM 3151 C CD1 . ILE B 2 318 ? 178.918 220.802 346.986 1.00 55.67  ? 318 ILE B CD1 1 
ATOM 3152 N N   . THR B 2 319 ? 182.331 216.443 344.894 1.00 51.75  ? 319 THR B N   1 
ATOM 3153 C CA  . THR B 2 319 ? 183.682 215.942 344.686 1.00 57.36  ? 319 THR B CA  1 
ATOM 3154 C C   . THR B 2 319 ? 184.384 216.799 343.648 1.00 52.54  ? 319 THR B C   1 
ATOM 3155 O O   . THR B 2 319 ? 183.880 216.968 342.533 1.00 61.91  ? 319 THR B O   1 
ATOM 3156 C CB  . THR B 2 319 ? 183.677 214.482 344.224 1.00 60.23  ? 319 THR B CB  1 
ATOM 3157 O OG1 . THR B 2 319 ? 183.213 214.407 342.871 1.00 60.59  ? 319 THR B OG1 1 
ATOM 3158 C CG2 . THR B 2 319 ? 182.777 213.647 345.106 1.00 59.97  ? 319 THR B CG2 1 
ATOM 3159 N N   . LEU B 2 320 ? 185.541 217.336 344.018 1.00 44.40  ? 320 LEU B N   1 
ATOM 3160 C CA  . LEU B 2 320 ? 186.422 217.986 343.065 1.00 49.25  ? 320 LEU B CA  1 
ATOM 3161 C C   . LEU B 2 320 ? 187.394 216.967 342.499 1.00 45.23  ? 320 LEU B C   1 
ATOM 3162 O O   . LEU B 2 320 ? 187.698 215.953 343.129 1.00 58.40  ? 320 LEU B O   1 
ATOM 3163 C CB  . LEU B 2 320 ? 187.193 219.133 343.713 1.00 51.95  ? 320 LEU B CB  1 
ATOM 3164 C CG  . LEU B 2 320 ? 186.370 220.381 344.009 1.00 55.89  ? 320 LEU B CG  1 
ATOM 3165 C CD1 . LEU B 2 320 ? 185.776 220.301 345.398 1.00 58.66  ? 320 LEU B CD1 1 
ATOM 3166 C CD2 . LEU B 2 320 ? 187.217 221.625 343.848 1.00 50.41  ? 320 LEU B CD2 1 
ATOM 3167 N N   . THR B 2 321 ? 187.883 217.245 341.297 1.00 45.43  ? 321 THR B N   1 
ATOM 3168 C CA  . THR B 2 321 ? 188.763 216.320 340.590 1.00 47.50  ? 321 THR B CA  1 
ATOM 3169 C C   . THR B 2 321 ? 189.722 217.151 339.748 1.00 51.99  ? 321 THR B C   1 
ATOM 3170 O O   . THR B 2 321 ? 189.388 217.556 338.632 1.00 62.77  ? 321 THR B O   1 
ATOM 3171 C CB  . THR B 2 321 ? 187.955 215.353 339.738 1.00 56.77  ? 321 THR B CB  1 
ATOM 3172 O OG1 . THR B 2 321 ? 187.364 214.355 340.577 1.00 63.40  ? 321 THR B OG1 1 
ATOM 3173 C CG2 . THR B 2 321 ? 188.828 214.692 338.716 1.00 60.03  ? 321 THR B CG2 1 
ATOM 3174 N N   . ILE B 2 322 ? 190.911 217.392 340.283 1.00 56.00  ? 322 ILE B N   1 
ATOM 3175 C CA  . ILE B 2 322 ? 191.883 218.286 339.667 1.00 55.48  ? 322 ILE B CA  1 
ATOM 3176 C C   . ILE B 2 322 ? 192.843 217.462 338.823 1.00 58.80  ? 322 ILE B C   1 
ATOM 3177 O O   . ILE B 2 322 ? 193.362 216.438 339.280 1.00 66.50  ? 322 ILE B O   1 
ATOM 3178 C CB  . ILE B 2 322 ? 192.638 219.088 340.736 1.00 52.45  ? 322 ILE B CB  1 
ATOM 3179 C CG1 . ILE B 2 322 ? 191.653 219.822 341.644 1.00 52.99  ? 322 ILE B CG1 1 
ATOM 3180 C CG2 . ILE B 2 322 ? 193.573 220.076 340.080 1.00 59.27  ? 322 ILE B CG2 1 
ATOM 3181 C CD1 . ILE B 2 322 ? 192.231 220.199 342.973 1.00 60.07  ? 322 ILE B CD1 1 
ATOM 3182 N N   . ALA B 2 323 ? 193.076 217.904 337.591 1.00 60.96  ? 323 ALA B N   1 
ATOM 3183 C CA  . ALA B 2 323 ? 193.919 217.189 336.634 1.00 63.27  ? 323 ALA B CA  1 
ATOM 3184 C C   . ALA B 2 323 ? 194.953 218.149 336.067 1.00 61.44  ? 323 ALA B C   1 
ATOM 3185 O O   . ALA B 2 323 ? 194.731 218.765 335.017 1.00 67.24  ? 323 ALA B O   1 
ATOM 3186 C CB  . ALA B 2 323 ? 193.082 216.574 335.516 1.00 63.03  ? 323 ALA B CB  1 
ATOM 3187 N N   . PRO B 2 324 ? 196.097 218.298 336.732 1.00 54.36  ? 324 PRO B N   1 
ATOM 3188 C CA  . PRO B 2 324 ? 197.132 219.203 336.220 1.00 59.68  ? 324 PRO B CA  1 
ATOM 3189 C C   . PRO B 2 324 ? 197.443 218.961 334.755 1.00 58.23  ? 324 PRO B C   1 
ATOM 3190 O O   . PRO B 2 324 ? 197.754 217.837 334.355 1.00 58.61  ? 324 PRO B O   1 
ATOM 3191 C CB  . PRO B 2 324 ? 198.338 218.888 337.110 1.00 58.50  ? 324 PRO B CB  1 
ATOM 3192 C CG  . PRO B 2 324 ? 197.741 218.401 338.378 1.00 62.84  ? 324 PRO B CG  1 
ATOM 3193 C CD  . PRO B 2 324 ? 196.501 217.656 337.993 1.00 57.65  ? 324 PRO B CD  1 
ATOM 3194 N N   . MET B 2 325 ? 197.358 220.013 333.948 1.00 62.76  ? 325 MET B N   1 
ATOM 3195 C CA  . MET B 2 325 ? 197.614 219.939 332.519 1.00 61.12  ? 325 MET B CA  1 
ATOM 3196 C C   . MET B 2 325 ? 198.886 220.700 332.184 1.00 66.20  ? 325 MET B C   1 
ATOM 3197 O O   . MET B 2 325 ? 199.149 221.767 332.748 1.00 64.81  ? 325 MET B O   1 
ATOM 3198 C CB  . MET B 2 325 ? 196.454 220.526 331.716 1.00 62.22  ? 325 MET B CB  1 
ATOM 3199 C CG  . MET B 2 325 ? 195.107 219.910 332.010 1.00 66.47  ? 325 MET B CG  1 
ATOM 3200 S SD  . MET B 2 325 ? 193.796 220.648 331.020 1.00 71.71  ? 325 MET B SD  1 
ATOM 3201 C CE  . MET B 2 325 ? 194.304 220.177 329.370 1.00 63.44  ? 325 MET B CE  1 
ATOM 3202 N N   . CYS B 2 326 ? 199.671 220.145 331.265 1.00 75.51  ? 326 CYS B N   1 
ATOM 3203 C CA  . CYS B 2 326 ? 200.841 220.829 330.723 1.00 73.79  ? 326 CYS B CA  1 
ATOM 3204 C C   . CYS B 2 326 ? 201.761 221.311 331.839 1.00 68.67  ? 326 CYS B C   1 
ATOM 3205 O O   . CYS B 2 326 ? 202.330 222.402 331.777 1.00 71.44  ? 326 CYS B O   1 
ATOM 3206 C CB  . CYS B 2 326 ? 200.417 221.993 329.830 1.00 75.31  ? 326 CYS B CB  1 
ATOM 3207 S SG  . CYS B 2 326 ? 199.139 221.571 328.626 1.00 70.78  ? 326 CYS B SG  1 
ATOM 3208 N N   . CYS B 2 327 ? 201.910 220.489 332.872 1.00 74.00  ? 327 CYS B N   1 
ATOM 3209 C CA  . CYS B 2 327 ? 202.775 220.853 333.984 1.00 78.45  ? 327 CYS B CA  1 
ATOM 3210 C C   . CYS B 2 327 ? 204.237 220.766 333.570 1.00 84.67  ? 327 CYS B C   1 
ATOM 3211 O O   . CYS B 2 327 ? 204.649 219.846 332.859 1.00 84.55  ? 327 CYS B O   1 
ATOM 3212 C CB  . CYS B 2 327 ? 202.512 219.953 335.191 1.00 76.43  ? 327 CYS B CB  1 
ATOM 3213 S SG  . CYS B 2 327 ? 202.254 218.219 334.791 1.00 86.43  ? 327 CYS B SG  1 
ATOM 3214 N N   . GLU B 2 328 ? 205.018 221.745 334.016 1.00 87.41  ? 328 GLU B N   1 
ATOM 3215 C CA  . GLU B 2 328 ? 206.443 221.818 333.739 1.00 81.84  ? 328 GLU B CA  1 
ATOM 3216 C C   . GLU B 2 328 ? 207.147 222.294 334.993 1.00 80.55  ? 328 GLU B C   1 
ATOM 3217 O O   . GLU B 2 328 ? 206.794 223.340 335.547 1.00 87.88  ? 328 GLU B O   1 
ATOM 3218 C CB  . GLU B 2 328 ? 206.745 222.780 332.590 1.00 81.34  ? 328 GLU B CB  1 
ATOM 3219 C CG  . GLU B 2 328 ? 205.920 222.551 331.350 1.00 86.46  ? 328 GLU B CG  1 
ATOM 3220 C CD  . GLU B 2 328 ? 206.133 223.639 330.327 1.00 89.15  ? 328 GLU B CD  1 
ATOM 3221 O OE1 . GLU B 2 328 ? 206.855 224.608 330.640 1.00 87.09  ? 328 GLU B OE1 1 
ATOM 3222 O OE2 . GLU B 2 328 ? 205.582 223.528 329.214 1.00 90.11  ? 328 GLU B OE2 1 
ATOM 3223 N N   . PHE B 2 329 ? 208.142 221.532 335.429 1.00 78.98  ? 329 PHE B N   1 
ATOM 3224 C CA  . PHE B 2 329 ? 208.968 221.892 336.568 1.00 80.88  ? 329 PHE B CA  1 
ATOM 3225 C C   . PHE B 2 329 ? 210.411 222.031 336.110 1.00 80.19  ? 329 PHE B C   1 
ATOM 3226 O O   . PHE B 2 329 ? 210.904 221.218 335.323 1.00 84.37  ? 329 PHE B O   1 
ATOM 3227 C CB  . PHE B 2 329 ? 208.874 220.847 337.678 1.00 82.83  ? 329 PHE B CB  1 
ATOM 3228 C CG  . PHE B 2 329 ? 207.469 220.463 338.036 1.00 80.45  ? 329 PHE B CG  1 
ATOM 3229 C CD1 . PHE B 2 329 ? 206.846 219.405 337.403 1.00 81.83  ? 329 PHE B CD1 1 
ATOM 3230 C CD2 . PHE B 2 329 ? 206.778 221.150 339.017 1.00 79.26  ? 329 PHE B CD2 1 
ATOM 3231 C CE1 . PHE B 2 329 ? 205.560 219.045 337.736 1.00 82.17  ? 329 PHE B CE1 1 
ATOM 3232 C CE2 . PHE B 2 329 ? 205.491 220.793 339.351 1.00 79.27  ? 329 PHE B CE2 1 
ATOM 3233 C CZ  . PHE B 2 329 ? 204.882 219.741 338.711 1.00 82.38  ? 329 PHE B CZ  1 
ATOM 3234 N N   . ASN B 2 330 ? 211.077 223.068 336.600 1.00 69.92  ? 330 ASN B N   1 
ATOM 3235 C CA  . ASN B 2 330 ? 212.478 223.319 336.317 1.00 69.99  ? 330 ASN B CA  1 
ATOM 3236 C C   . ASN B 2 330 ? 213.229 223.485 337.631 1.00 71.69  ? 330 ASN B C   1 
ATOM 3237 O O   . ASN B 2 330 ? 212.734 224.094 338.585 1.00 78.17  ? 330 ASN B O   1 
ATOM 3238 C CB  . ASN B 2 330 ? 212.652 224.560 335.440 1.00 73.10  ? 330 ASN B CB  1 
ATOM 3239 C CG  . ASN B 2 330 ? 213.917 224.514 334.617 1.00 74.38  ? 330 ASN B CG  1 
ATOM 3240 O OD1 . ASN B 2 330 ? 214.865 223.807 334.957 1.00 75.05  ? 330 ASN B OD1 1 
ATOM 3241 N ND2 . ASN B 2 330 ? 213.939 225.263 333.521 1.00 75.73  ? 330 ASN B ND2 1 
ATOM 3242 N N   . GLY B 2 331 ? 214.441 222.939 337.662 1.00 70.00  ? 331 GLY B N   1 
ATOM 3243 C CA  . GLY B 2 331 ? 215.195 222.820 338.891 1.00 65.63  ? 331 GLY B CA  1 
ATOM 3244 C C   . GLY B 2 331 ? 215.057 221.439 339.498 1.00 75.87  ? 331 GLY B C   1 
ATOM 3245 O O   . GLY B 2 331 ? 214.445 220.525 338.940 1.00 76.04  ? 331 GLY B O   1 
ATOM 3246 N N   . LEU B 2 332 ? 215.660 221.283 340.669 1.00 84.06  ? 332 LEU B N   1 
ATOM 3247 C CA  . LEU B 2 332 ? 215.554 220.050 341.442 1.00 82.16  ? 332 LEU B CA  1 
ATOM 3248 C C   . LEU B 2 332 ? 216.277 220.278 342.763 1.00 80.77  ? 332 LEU B C   1 
ATOM 3249 O O   . LEU B 2 332 ? 217.098 221.191 342.891 1.00 84.30  ? 332 LEU B O   1 
ATOM 3250 C CB  . LEU B 2 332 ? 216.122 218.853 340.679 1.00 76.72  ? 332 LEU B CB  1 
ATOM 3251 C CG  . LEU B 2 332 ? 215.117 217.725 340.439 1.00 77.28  ? 332 LEU B CG  1 
ATOM 3252 C CD1 . LEU B 2 332 ? 215.685 216.678 339.495 1.00 80.87  ? 332 LEU B CD1 1 
ATOM 3253 C CD2 . LEU B 2 332 ? 214.710 217.087 341.756 1.00 78.41  ? 332 LEU B CD2 1 
ATOM 3254 N N   . ARG B 2 333 ? 215.960 219.446 343.749 1.00 88.29  ? 333 ARG B N   1 
ATOM 3255 C CA  . ARG B 2 333 ? 216.473 219.637 345.100 1.00 91.66  ? 333 ARG B CA  1 
ATOM 3256 C C   . ARG B 2 333 ? 216.896 218.295 345.696 1.00 92.45  ? 333 ARG B C   1 
ATOM 3257 O O   . ARG B 2 333 ? 216.627 217.992 346.859 1.00 93.87  ? 333 ARG B O   1 
ATOM 3258 C CB  . ARG B 2 333 ? 215.428 220.329 345.974 1.00 87.52  ? 333 ARG B CB  1 
ATOM 3259 C CG  . ARG B 2 333 ? 215.942 220.762 347.330 1.00 86.03  ? 333 ARG B CG  1 
ATOM 3260 C CD  . ARG B 2 333 ? 214.935 220.447 348.417 1.00 89.65  ? 333 ARG B CD  1 
ATOM 3261 N NE  . ARG B 2 333 ? 213.669 221.136 348.198 1.00 94.82  ? 333 ARG B NE  1 
ATOM 3262 C CZ  . ARG B 2 333 ? 213.303 222.261 348.799 1.00 92.84  ? 333 ARG B CZ  1 
ATOM 3263 N NH1 . ARG B 2 333 ? 214.081 222.862 349.686 1.00 91.18  ? 333 ARG B NH1 1 
ATOM 3264 N NH2 . ARG B 2 333 ? 212.121 222.797 348.506 1.00 86.96  ? 333 ARG B NH2 1 
ATOM 3265 N N   . ASN B 2 334 ? 217.569 217.469 344.897 1.00 97.58  ? 334 ASN B N   1 
ATOM 3266 C CA  . ASN B 2 334 ? 218.090 216.200 345.389 1.00 99.21  ? 334 ASN B CA  1 
ATOM 3267 C C   . ASN B 2 334 ? 216.952 215.347 345.942 1.00 99.31  ? 334 ASN B C   1 
ATOM 3268 O O   . ASN B 2 334 ? 215.798 215.523 345.539 1.00 98.18  ? 334 ASN B O   1 
ATOM 3269 C CB  . ASN B 2 334 ? 219.123 216.469 346.487 1.00 99.01  ? 334 ASN B CB  1 
ATOM 3270 C CG  . ASN B 2 334 ? 220.135 215.353 346.634 1.00 100.10 ? 334 ASN B CG  1 
ATOM 3271 O OD1 . ASN B 2 334 ? 220.185 214.682 347.661 1.00 97.49  ? 334 ASN B OD1 1 
ATOM 3272 N ND2 . ASN B 2 334 ? 220.968 215.169 345.618 1.00 98.82  ? 334 ASN B ND2 1 
ATOM 3273 N N   . ILE B 2 335 ? 217.270 214.445 346.872 1.00 94.79  ? 335 ILE B N   1 
ATOM 3274 C CA  . ILE B 2 335 ? 216.291 213.653 347.624 1.00 97.17  ? 335 ILE B CA  1 
ATOM 3275 C C   . ILE B 2 335 ? 214.969 213.466 346.884 1.00 95.00  ? 335 ILE B C   1 
ATOM 3276 O O   . ILE B 2 335 ? 214.612 212.352 346.503 1.00 93.73  ? 335 ILE B O   1 
ATOM 3277 C CB  . ILE B 2 335 ? 216.047 214.290 349.012 1.00 96.99  ? 335 ILE B CB  1 
ATOM 3278 C CG1 . ILE B 2 335 ? 215.002 213.494 349.799 1.00 94.38  ? 335 ILE B CG1 1 
ATOM 3279 C CG2 . ILE B 2 335 ? 215.630 215.747 348.869 1.00 94.06  ? 335 ILE B CG2 1 
ATOM 3280 C CD1 . ILE B 2 335 ? 214.889 213.910 351.251 1.00 88.95  ? 335 ILE B CD1 1 
ATOM 3281 N N   . GLY C 3 1   ? 217.715 281.477 313.630 1.00 114.69 ? 1   GLY C N   1 
ATOM 3282 C CA  . GLY C 3 1   ? 216.600 282.131 312.887 1.00 115.09 ? 1   GLY C CA  1 
ATOM 3283 C C   . GLY C 3 1   ? 215.284 281.399 313.057 1.00 117.03 ? 1   GLY C C   1 
ATOM 3284 O O   . GLY C 3 1   ? 214.959 280.944 314.153 1.00 116.07 ? 1   GLY C O   1 
ATOM 3285 N N   . LEU C 3 2   ? 214.532 281.282 311.966 1.00 130.41 ? 2   LEU C N   1 
ATOM 3286 C CA  . LEU C 3 2   ? 213.225 280.635 311.970 1.00 130.47 ? 2   LEU C CA  1 
ATOM 3287 C C   . LEU C 3 2   ? 212.381 281.155 313.137 1.00 131.57 ? 2   LEU C C   1 
ATOM 3288 O O   . LEU C 3 2   ? 212.078 280.408 314.073 1.00 132.35 ? 2   LEU C O   1 
ATOM 3289 C CB  . LEU C 3 2   ? 213.363 279.121 312.039 1.00 130.04 ? 2   LEU C CB  1 
ATOM 3290 C CG  . LEU C 3 2   ? 212.055 278.336 311.916 1.00 128.82 ? 2   LEU C CG  1 
ATOM 3291 C CD1 . LEU C 3 2   ? 211.728 278.065 310.456 1.00 129.62 ? 2   LEU C CD1 1 
ATOM 3292 C CD2 . LEU C 3 2   ? 212.127 277.043 312.707 1.00 128.07 ? 2   LEU C CD2 1 
ATOM 3293 N N   . PRO C 3 3   ? 211.990 282.426 313.111 1.00 132.18 ? 3   PRO C N   1 
ATOM 3294 C CA  . PRO C 3 3   ? 211.296 283.005 314.265 1.00 132.15 ? 3   PRO C CA  1 
ATOM 3295 C C   . PRO C 3 3   ? 209.999 282.269 314.569 1.00 132.00 ? 3   PRO C C   1 
ATOM 3296 O O   . PRO C 3 3   ? 209.305 281.793 313.667 1.00 131.71 ? 3   PRO C O   1 
ATOM 3297 C CB  . PRO C 3 3   ? 211.040 284.454 313.836 1.00 131.87 ? 3   PRO C CB  1 
ATOM 3298 C CG  . PRO C 3 3   ? 211.950 284.700 312.680 1.00 130.93 ? 3   PRO C CG  1 
ATOM 3299 C CD  . PRO C 3 3   ? 212.121 283.386 312.004 1.00 131.03 ? 3   PRO C CD  1 
ATOM 3300 N N   . VAL C 3 4   ? 209.678 282.173 315.856 1.00 129.52 ? 4   VAL C N   1 
ATOM 3301 C CA  . VAL C 3 4   ? 208.489 281.475 316.331 1.00 130.01 ? 4   VAL C CA  1 
ATOM 3302 C C   . VAL C 3 4   ? 207.742 282.392 317.288 1.00 128.94 ? 4   VAL C C   1 
ATOM 3303 O O   . VAL C 3 4   ? 208.355 283.022 318.157 1.00 129.15 ? 4   VAL C O   1 
ATOM 3304 C CB  . VAL C 3 4   ? 208.852 280.146 317.017 1.00 129.52 ? 4   VAL C CB  1 
ATOM 3305 C CG1 . VAL C 3 4   ? 209.641 279.258 316.067 1.00 126.99 ? 4   VAL C CG1 1 
ATOM 3306 C CG2 . VAL C 3 4   ? 209.636 280.401 318.294 1.00 128.03 ? 4   VAL C CG2 1 
ATOM 3307 N N   . MET C 3 5   ? 206.422 282.466 317.126 1.00 126.84 ? 5   MET C N   1 
ATOM 3308 C CA  . MET C 3 5   ? 205.563 283.280 317.976 1.00 126.31 ? 5   MET C CA  1 
ATOM 3309 C C   . MET C 3 5   ? 204.743 282.368 318.879 1.00 125.75 ? 5   MET C C   1 
ATOM 3310 O O   . MET C 3 5   ? 203.907 281.601 318.393 1.00 123.35 ? 5   MET C O   1 
ATOM 3311 C CB  . MET C 3 5   ? 204.632 284.151 317.134 1.00 127.89 ? 5   MET C CB  1 
ATOM 3312 C CG  . MET C 3 5   ? 205.342 285.074 316.164 1.00 128.80 ? 5   MET C CG  1 
ATOM 3313 S SD  . MET C 3 5   ? 204.211 285.855 314.993 1.00 130.56 ? 5   MET C SD  1 
ATOM 3314 C CE  . MET C 3 5   ? 203.210 286.857 316.086 1.00 123.94 ? 5   MET C CE  1 
ATOM 3315 N N   . ASN C 3 6   ? 204.965 282.461 320.186 1.00 129.99 ? 6   ASN C N   1 
ATOM 3316 C CA  . ASN C 3 6   ? 204.145 281.704 321.118 1.00 130.86 ? 6   ASN C CA  1 
ATOM 3317 C C   . ASN C 3 6   ? 202.714 282.233 321.101 1.00 131.20 ? 6   ASN C C   1 
ATOM 3318 O O   . ASN C 3 6   ? 202.467 283.411 320.834 1.00 131.87 ? 6   ASN C O   1 
ATOM 3319 C CB  . ASN C 3 6   ? 204.723 281.779 322.531 1.00 127.87 ? 6   ASN C CB  1 
ATOM 3320 C CG  . ASN C 3 6   ? 204.284 283.018 323.272 1.00 129.23 ? 6   ASN C CG  1 
ATOM 3321 O OD1 . ASN C 3 6   ? 204.169 284.096 322.693 1.00 128.72 ? 6   ASN C OD1 1 
ATOM 3322 N ND2 . ASN C 3 6   ? 204.031 282.870 324.567 1.00 128.40 ? 6   ASN C ND2 1 
ATOM 3323 N N   . THR C 3 7   ? 201.768 281.347 321.383 1.00 119.64 ? 7   THR C N   1 
ATOM 3324 C CA  . THR C 3 7   ? 200.349 281.638 321.284 1.00 117.96 ? 7   THR C CA  1 
ATOM 3325 C C   . THR C 3 7   ? 199.714 281.662 322.667 1.00 118.05 ? 7   THR C C   1 
ATOM 3326 O O   . THR C 3 7   ? 200.345 281.275 323.657 1.00 118.92 ? 7   THR C O   1 
ATOM 3327 C CB  . THR C 3 7   ? 199.630 280.590 320.422 1.00 119.07 ? 7   THR C CB  1 
ATOM 3328 O OG1 . THR C 3 7   ? 199.452 279.386 321.176 1.00 119.98 ? 7   THR C OG1 1 
ATOM 3329 C CG2 . THR C 3 7   ? 200.434 280.280 319.180 1.00 118.53 ? 7   THR C CG2 1 
ATOM 3330 N N   . PRO C 3 8   ? 198.470 282.126 322.774 1.00 112.05 ? 8   PRO C N   1 
ATOM 3331 C CA  . PRO C 3 8   ? 197.734 281.946 324.028 1.00 111.04 ? 8   PRO C CA  1 
ATOM 3332 C C   . PRO C 3 8   ? 197.581 280.468 324.345 1.00 112.64 ? 8   PRO C C   1 
ATOM 3333 O O   . PRO C 3 8   ? 197.399 279.638 323.452 1.00 110.74 ? 8   PRO C O   1 
ATOM 3334 C CB  . PRO C 3 8   ? 196.383 282.612 323.748 1.00 109.86 ? 8   PRO C CB  1 
ATOM 3335 C CG  . PRO C 3 8   ? 196.652 283.568 322.642 1.00 110.34 ? 8   PRO C CG  1 
ATOM 3336 C CD  . PRO C 3 8   ? 197.710 282.926 321.801 1.00 112.95 ? 8   PRO C CD  1 
ATOM 3337 N N   . GLY C 3 9   ? 197.664 280.141 325.630 1.00 103.74 ? 9   GLY C N   1 
ATOM 3338 C CA  . GLY C 3 9   ? 197.605 278.757 326.046 1.00 99.59  ? 9   GLY C CA  1 
ATOM 3339 C C   . GLY C 3 9   ? 198.966 278.095 326.020 1.00 99.16  ? 9   GLY C C   1 
ATOM 3340 O O   . GLY C 3 9   ? 199.104 276.956 325.568 1.00 99.35  ? 9   GLY C O   1 
ATOM 3341 N N   . SER C 3 10  ? 199.982 278.808 326.496 1.00 101.10 ? 10  SER C N   1 
ATOM 3342 C CA  . SER C 3 10  ? 201.337 278.294 326.596 1.00 98.96  ? 10  SER C CA  1 
ATOM 3343 C C   . SER C 3 10  ? 201.831 278.454 328.027 1.00 101.21 ? 10  SER C C   1 
ATOM 3344 O O   . SER C 3 10  ? 201.317 279.273 328.794 1.00 101.56 ? 10  SER C O   1 
ATOM 3345 C CB  . SER C 3 10  ? 202.276 279.014 325.621 1.00 99.14  ? 10  SER C CB  1 
ATOM 3346 O OG  . SER C 3 10  ? 201.923 278.733 324.279 1.00 100.63 ? 10  SER C OG  1 
ATOM 3347 N N   . ASN C 3 11  ? 202.839 277.657 328.383 1.00 96.59  ? 11  ASN C N   1 
ATOM 3348 C CA  . ASN C 3 11  ? 203.333 277.588 329.758 1.00 95.43  ? 11  ASN C CA  1 
ATOM 3349 C C   . ASN C 3 11  ? 202.246 277.116 330.716 1.00 97.87  ? 11  ASN C C   1 
ATOM 3350 O O   . ASN C 3 11  ? 202.211 277.522 331.880 1.00 98.23  ? 11  ASN C O   1 
ATOM 3351 C CB  . ASN C 3 11  ? 203.886 278.937 330.230 1.00 96.82  ? 11  ASN C CB  1 
ATOM 3352 C CG  . ASN C 3 11  ? 205.081 279.395 329.428 1.00 97.39  ? 11  ASN C CG  1 
ATOM 3353 O OD1 . ASN C 3 11  ? 205.195 279.106 328.239 1.00 99.04  ? 11  ASN C OD1 1 
ATOM 3354 N ND2 . ASN C 3 11  ? 205.986 280.115 330.079 1.00 97.60  ? 11  ASN C ND2 1 
ATOM 3355 N N   . GLN C 3 12  ? 201.350 276.256 330.239 1.00 94.67  ? 12  GLN C N   1 
ATOM 3356 C CA  . GLN C 3 12  ? 200.217 275.795 331.026 1.00 91.24  ? 12  GLN C CA  1 
ATOM 3357 C C   . GLN C 3 12  ? 200.226 274.276 331.089 1.00 93.74  ? 12  GLN C C   1 
ATOM 3358 O O   . GLN C 3 12  ? 200.858 273.602 330.272 1.00 94.21  ? 12  GLN C O   1 
ATOM 3359 C CB  . GLN C 3 12  ? 198.885 276.280 330.441 1.00 90.42  ? 12  GLN C CB  1 
ATOM 3360 C CG  . GLN C 3 12  ? 198.527 275.661 329.098 1.00 91.80  ? 12  GLN C CG  1 
ATOM 3361 C CD  . GLN C 3 12  ? 197.147 276.056 328.637 1.00 91.93  ? 12  GLN C CD  1 
ATOM 3362 O OE1 . GLN C 3 12  ? 196.606 277.068 329.074 1.00 96.16  ? 12  GLN C OE1 1 
ATOM 3363 N NE2 . GLN C 3 12  ? 196.562 275.255 327.757 1.00 89.72  ? 12  GLN C NE2 1 
ATOM 3364 N N   . TYR C 3 13  ? 199.504 273.746 332.071 1.00 92.80  ? 13  TYR C N   1 
ATOM 3365 C CA  . TYR C 3 13  ? 199.370 272.308 332.282 1.00 88.71  ? 13  TYR C CA  1 
ATOM 3366 C C   . TYR C 3 13  ? 197.894 271.950 332.163 1.00 88.13  ? 13  TYR C C   1 
ATOM 3367 O O   . TYR C 3 13  ? 197.161 271.950 333.154 1.00 92.10  ? 13  TYR C O   1 
ATOM 3368 C CB  . TYR C 3 13  ? 199.936 271.904 333.637 1.00 88.26  ? 13  TYR C CB  1 
ATOM 3369 C CG  . TYR C 3 13  ? 199.777 270.438 333.976 1.00 86.84  ? 13  TYR C CG  1 
ATOM 3370 C CD1 . TYR C 3 13  ? 199.648 269.480 332.982 1.00 90.87  ? 13  TYR C CD1 1 
ATOM 3371 C CD2 . TYR C 3 13  ? 199.751 270.015 335.295 1.00 86.14  ? 13  TYR C CD2 1 
ATOM 3372 C CE1 . TYR C 3 13  ? 199.500 268.145 333.292 1.00 92.32  ? 13  TYR C CE1 1 
ATOM 3373 C CE2 . TYR C 3 13  ? 199.604 268.684 335.615 1.00 90.04  ? 13  TYR C CE2 1 
ATOM 3374 C CZ  . TYR C 3 13  ? 199.479 267.752 334.610 1.00 91.89  ? 13  TYR C CZ  1 
ATOM 3375 O OH  . TYR C 3 13  ? 199.332 266.422 334.926 1.00 91.45  ? 13  TYR C OH  1 
ATOM 3376 N N   . LEU C 3 14  ? 197.458 271.654 330.944 1.00 86.84  ? 14  LEU C N   1 
ATOM 3377 C CA  . LEU C 3 14  ? 196.133 271.091 330.727 1.00 92.76  ? 14  LEU C CA  1 
ATOM 3378 C C   . LEU C 3 14  ? 196.206 269.591 330.972 1.00 96.12  ? 14  LEU C C   1 
ATOM 3379 O O   . LEU C 3 14  ? 196.968 268.887 330.301 1.00 97.05  ? 14  LEU C O   1 
ATOM 3380 C CB  . LEU C 3 14  ? 195.652 271.387 329.308 1.00 89.97  ? 14  LEU C CB  1 
ATOM 3381 C CG  . LEU C 3 14  ? 194.295 270.802 328.911 1.00 85.24  ? 14  LEU C CG  1 
ATOM 3382 C CD1 . LEU C 3 14  ? 193.168 271.500 329.646 1.00 86.52  ? 14  LEU C CD1 1 
ATOM 3383 C CD2 . LEU C 3 14  ? 194.098 270.900 327.415 1.00 87.40  ? 14  LEU C CD2 1 
ATOM 3384 N N   . THR C 3 15  ? 195.419 269.094 331.924 1.00 91.11  ? 15  THR C N   1 
ATOM 3385 C CA  . THR C 3 15  ? 195.504 267.680 332.263 1.00 85.62  ? 15  THR C CA  1 
ATOM 3386 C C   . THR C 3 15  ? 194.683 266.851 331.286 1.00 90.80  ? 15  THR C C   1 
ATOM 3387 O O   . THR C 3 15  ? 193.885 266.002 331.696 1.00 91.43  ? 15  THR C O   1 
ATOM 3388 C CB  . THR C 3 15  ? 195.023 267.438 333.696 1.00 85.73  ? 15  THR C CB  1 
ATOM 3389 O OG1 . THR C 3 15  ? 193.628 267.744 333.796 1.00 90.03  ? 15  THR C OG1 1 
ATOM 3390 C CG2 . THR C 3 15  ? 195.794 268.305 334.675 1.00 82.21  ? 15  THR C CG2 1 
ATOM 3391 N N   . ALA C 3 16  ? 194.869 267.098 329.990 1.00 96.32  ? 16  ALA C N   1 
ATOM 3392 C CA  . ALA C 3 16  ? 194.295 266.255 328.954 1.00 93.17  ? 16  ALA C CA  1 
ATOM 3393 C C   . ALA C 3 16  ? 195.199 266.103 327.740 1.00 98.36  ? 16  ALA C C   1 
ATOM 3394 O O   . ALA C 3 16  ? 194.791 265.452 326.774 1.00 100.25 ? 16  ALA C O   1 
ATOM 3395 C CB  . ALA C 3 16  ? 192.935 266.811 328.506 1.00 92.69  ? 16  ALA C CB  1 
ATOM 3396 N N   . ASP C 3 17  ? 196.402 266.670 327.753 1.00 110.91 ? 17  ASP C N   1 
ATOM 3397 C CA  . ASP C 3 17  ? 197.258 266.698 326.578 1.00 108.60 ? 17  ASP C CA  1 
ATOM 3398 C C   . ASP C 3 17  ? 198.173 265.479 326.544 1.00 108.48 ? 17  ASP C C   1 
ATOM 3399 O O   . ASP C 3 17  ? 198.351 264.772 327.537 1.00 104.93 ? 17  ASP C O   1 
ATOM 3400 C CB  . ASP C 3 17  ? 198.096 267.976 326.550 1.00 108.38 ? 17  ASP C CB  1 
ATOM 3401 C CG  . ASP C 3 17  ? 199.027 268.088 327.740 1.00 110.96 ? 17  ASP C CG  1 
ATOM 3402 O OD1 . ASP C 3 17  ? 198.688 267.545 328.812 1.00 111.85 ? 17  ASP C OD1 1 
ATOM 3403 O OD2 . ASP C 3 17  ? 200.095 268.721 327.604 1.00 109.49 ? 17  ASP C OD2 1 
ATOM 3404 N N   . ASN C 3 18  ? 198.758 265.245 325.368 1.00 108.92 ? 18  ASN C N   1 
ATOM 3405 C CA  . ASN C 3 18  ? 199.632 264.100 325.139 1.00 110.05 ? 18  ASN C CA  1 
ATOM 3406 C C   . ASN C 3 18  ? 201.013 264.523 324.656 1.00 110.98 ? 18  ASN C C   1 
ATOM 3407 O O   . ASN C 3 18  ? 201.716 263.726 324.027 1.00 111.75 ? 18  ASN C O   1 
ATOM 3408 C CB  . ASN C 3 18  ? 198.994 263.142 324.133 1.00 107.43 ? 18  ASN C CB  1 
ATOM 3409 C CG  . ASN C 3 18  ? 197.547 262.843 324.453 1.00 108.58 ? 18  ASN C CG  1 
ATOM 3410 O OD1 . ASN C 3 18  ? 196.673 262.955 323.594 1.00 110.99 ? 18  ASN C OD1 1 
ATOM 3411 N ND2 . ASN C 3 18  ? 197.282 262.469 325.698 1.00 108.12 ? 18  ASN C ND2 1 
ATOM 3412 N N   . PHE C 3 19  ? 201.419 265.759 324.936 1.00 107.77 ? 19  PHE C N   1 
ATOM 3413 C CA  . PHE C 3 19  ? 202.740 266.212 324.527 1.00 109.86 ? 19  PHE C CA  1 
ATOM 3414 C C   . PHE C 3 19  ? 203.809 265.293 325.103 1.00 112.23 ? 19  PHE C C   1 
ATOM 3415 O O   . PHE C 3 19  ? 203.751 264.901 326.272 1.00 111.74 ? 19  PHE C O   1 
ATOM 3416 C CB  . PHE C 3 19  ? 202.975 267.651 324.990 1.00 109.32 ? 19  PHE C CB  1 
ATOM 3417 C CG  . PHE C 3 19  ? 202.020 268.648 324.393 1.00 110.85 ? 19  PHE C CG  1 
ATOM 3418 C CD1 . PHE C 3 19  ? 201.544 268.491 323.102 1.00 109.55 ? 19  PHE C CD1 1 
ATOM 3419 C CD2 . PHE C 3 19  ? 201.600 269.745 325.126 1.00 110.52 ? 19  PHE C CD2 1 
ATOM 3420 C CE1 . PHE C 3 19  ? 200.668 269.408 322.555 1.00 108.89 ? 19  PHE C CE1 1 
ATOM 3421 C CE2 . PHE C 3 19  ? 200.725 270.664 324.584 1.00 107.77 ? 19  PHE C CE2 1 
ATOM 3422 C CZ  . PHE C 3 19  ? 200.258 270.495 323.297 1.00 107.29 ? 19  PHE C CZ  1 
ATOM 3423 N N   . GLN C 3 20  ? 204.788 264.949 324.271 1.00 112.52 ? 20  GLN C N   1 
ATOM 3424 C CA  . GLN C 3 20  ? 205.814 264.000 324.679 1.00 109.24 ? 20  GLN C CA  1 
ATOM 3425 C C   . GLN C 3 20  ? 206.584 264.527 325.882 1.00 108.52 ? 20  GLN C C   1 
ATOM 3426 O O   . GLN C 3 20  ? 206.847 265.727 325.998 1.00 107.19 ? 20  GLN C O   1 
ATOM 3427 C CB  . GLN C 3 20  ? 206.772 263.728 323.519 1.00 108.94 ? 20  GLN C CB  1 
ATOM 3428 C CG  . GLN C 3 20  ? 207.911 262.784 323.865 1.00 107.81 ? 20  GLN C CG  1 
ATOM 3429 C CD  . GLN C 3 20  ? 208.709 262.366 322.646 1.00 110.18 ? 20  GLN C CD  1 
ATOM 3430 O OE1 . GLN C 3 20  ? 208.341 262.676 321.513 1.00 112.27 ? 20  GLN C OE1 1 
ATOM 3431 N NE2 . GLN C 3 20  ? 209.808 261.656 322.872 1.00 108.74 ? 20  GLN C NE2 1 
ATOM 3432 N N   . SER C 3 21  ? 206.939 263.616 326.783 1.00 99.28  ? 21  SER C N   1 
ATOM 3433 C CA  . SER C 3 21  ? 207.684 263.940 327.985 1.00 97.53  ? 21  SER C CA  1 
ATOM 3434 C C   . SER C 3 21  ? 209.031 263.226 327.975 1.00 98.57  ? 21  SER C C   1 
ATOM 3435 O O   . SER C 3 21  ? 209.172 262.168 327.353 1.00 98.74  ? 21  SER C O   1 
ATOM 3436 C CB  . SER C 3 21  ? 206.899 263.539 329.239 1.00 96.22  ? 21  SER C CB  1 
ATOM 3437 O OG  . SER C 3 21  ? 206.525 262.175 329.184 1.00 97.42  ? 21  SER C OG  1 
ATOM 3438 N N   . PRO C 3 22  ? 210.040 263.776 328.651 1.00 79.91  ? 22  PRO C N   1 
ATOM 3439 C CA  . PRO C 3 22  ? 211.380 263.178 328.598 1.00 81.29  ? 22  PRO C CA  1 
ATOM 3440 C C   . PRO C 3 22  ? 211.494 261.989 329.542 1.00 83.48  ? 22  PRO C C   1 
ATOM 3441 O O   . PRO C 3 22  ? 211.189 262.093 330.732 1.00 83.89  ? 22  PRO C O   1 
ATOM 3442 C CB  . PRO C 3 22  ? 212.292 264.327 329.034 1.00 81.45  ? 22  PRO C CB  1 
ATOM 3443 C CG  . PRO C 3 22  ? 211.438 265.118 329.967 1.00 78.99  ? 22  PRO C CG  1 
ATOM 3444 C CD  . PRO C 3 22  ? 210.024 265.010 329.456 1.00 76.29  ? 22  PRO C CD  1 
ATOM 3445 N N   . CYS C 3 23  ? 211.945 260.856 329.006 1.00 74.85  ? 23  CYS C N   1 
ATOM 3446 C CA  . CYS C 3 23  ? 212.100 259.659 329.821 1.00 69.91  ? 23  CYS C CA  1 
ATOM 3447 C C   . CYS C 3 23  ? 213.109 259.902 330.932 1.00 64.37  ? 23  CYS C C   1 
ATOM 3448 O O   . CYS C 3 23  ? 214.176 260.477 330.709 1.00 73.28  ? 23  CYS C O   1 
ATOM 3449 C CB  . CYS C 3 23  ? 212.550 258.480 328.958 1.00 74.18  ? 23  CYS C CB  1 
ATOM 3450 S SG  . CYS C 3 23  ? 211.307 257.876 327.792 1.00 87.44  ? 23  CYS C SG  1 
ATOM 3451 N N   . ALA C 3 24  ? 212.763 259.462 332.142 1.00 49.84  ? 24  ALA C N   1 
ATOM 3452 C CA  . ALA C 3 24  ? 213.675 259.607 333.270 1.00 51.67  ? 24  ALA C CA  1 
ATOM 3453 C C   . ALA C 3 24  ? 214.823 258.613 333.202 1.00 56.64  ? 24  ALA C C   1 
ATOM 3454 O O   . ALA C 3 24  ? 215.936 258.930 333.634 1.00 58.97  ? 24  ALA C O   1 
ATOM 3455 C CB  . ALA C 3 24  ? 212.918 259.438 334.585 1.00 50.03  ? 24  ALA C CB  1 
ATOM 3456 N N   . LEU C 3 25  ? 214.580 257.420 332.664 1.00 66.74  ? 25  LEU C N   1 
ATOM 3457 C CA  . LEU C 3 25  ? 215.588 256.364 332.561 1.00 68.04  ? 25  LEU C CA  1 
ATOM 3458 C C   . LEU C 3 25  ? 215.660 255.931 331.104 1.00 71.52  ? 25  LEU C C   1 
ATOM 3459 O O   . LEU C 3 25  ? 215.110 254.890 330.724 1.00 72.38  ? 25  LEU C O   1 
ATOM 3460 C CB  . LEU C 3 25  ? 215.250 255.185 333.473 1.00 63.12  ? 25  LEU C CB  1 
ATOM 3461 C CG  . LEU C 3 25  ? 214.993 255.531 334.940 1.00 63.67  ? 25  LEU C CG  1 
ATOM 3462 C CD1 . LEU C 3 25  ? 214.589 254.292 335.712 1.00 60.82  ? 25  LEU C CD1 1 
ATOM 3463 C CD2 . LEU C 3 25  ? 216.215 256.173 335.569 1.00 66.44  ? 25  LEU C CD2 1 
ATOM 3464 N N   . PRO C 3 26  ? 216.334 256.710 330.256 1.00 70.60  ? 26  PRO C N   1 
ATOM 3465 C CA  . PRO C 3 26  ? 216.355 256.410 328.821 1.00 70.64  ? 26  PRO C CA  1 
ATOM 3466 C C   . PRO C 3 26  ? 217.280 255.271 328.431 1.00 71.60  ? 26  PRO C C   1 
ATOM 3467 O O   . PRO C 3 26  ? 217.412 254.988 327.235 1.00 69.39  ? 26  PRO C O   1 
ATOM 3468 C CB  . PRO C 3 26  ? 216.834 257.732 328.212 1.00 68.50  ? 26  PRO C CB  1 
ATOM 3469 C CG  . PRO C 3 26  ? 217.717 258.306 329.255 1.00 70.26  ? 26  PRO C CG  1 
ATOM 3470 C CD  . PRO C 3 26  ? 217.123 257.910 330.579 1.00 66.34  ? 26  PRO C CD  1 
ATOM 3471 N N   . GLU C 3 27  ? 217.921 254.616 329.394 1.00 69.77  ? 27  GLU C N   1 
ATOM 3472 C CA  . GLU C 3 27  ? 218.863 253.531 329.143 1.00 69.32  ? 27  GLU C CA  1 
ATOM 3473 C C   . GLU C 3 27  ? 218.459 252.301 329.938 1.00 72.23  ? 27  GLU C C   1 
ATOM 3474 O O   . GLU C 3 27  ? 219.275 251.643 330.583 1.00 76.66  ? 27  GLU C O   1 
ATOM 3475 C CB  . GLU C 3 27  ? 220.279 253.977 329.484 1.00 71.18  ? 27  GLU C CB  1 
ATOM 3476 C CG  . GLU C 3 27  ? 220.760 255.133 328.623 1.00 76.08  ? 27  GLU C CG  1 
ATOM 3477 C CD  . GLU C 3 27  ? 222.050 255.743 329.119 1.00 78.47  ? 27  GLU C CD  1 
ATOM 3478 O OE1 . GLU C 3 27  ? 222.555 255.299 330.171 1.00 78.94  ? 27  GLU C OE1 1 
ATOM 3479 O OE2 . GLU C 3 27  ? 222.558 256.671 328.456 1.00 75.27  ? 27  GLU C OE2 1 
ATOM 3480 N N   . PHE C 3 28  ? 217.169 251.978 329.887 1.00 61.31  ? 28  PHE C N   1 
ATOM 3481 C CA  . PHE C 3 28  ? 216.578 250.913 330.685 1.00 56.68  ? 28  PHE C CA  1 
ATOM 3482 C C   . PHE C 3 28  ? 215.891 249.927 329.754 1.00 59.21  ? 28  PHE C C   1 
ATOM 3483 O O   . PHE C 3 28  ? 215.119 250.332 328.880 1.00 58.34  ? 28  PHE C O   1 
ATOM 3484 C CB  . PHE C 3 28  ? 215.578 251.495 331.688 1.00 57.41  ? 28  PHE C CB  1 
ATOM 3485 C CG  . PHE C 3 28  ? 215.083 250.510 332.701 1.00 55.50  ? 28  PHE C CG  1 
ATOM 3486 C CD1 . PHE C 3 28  ? 213.970 249.736 332.447 1.00 59.06  ? 28  PHE C CD1 1 
ATOM 3487 C CD2 . PHE C 3 28  ? 215.718 250.374 333.918 1.00 56.18  ? 28  PHE C CD2 1 
ATOM 3488 C CE1 . PHE C 3 28  ? 213.511 248.839 333.381 1.00 57.11  ? 28  PHE C CE1 1 
ATOM 3489 C CE2 . PHE C 3 28  ? 215.260 249.478 334.854 1.00 56.85  ? 28  PHE C CE2 1 
ATOM 3490 C CZ  . PHE C 3 28  ? 214.158 248.711 334.585 1.00 55.24  ? 28  PHE C CZ  1 
ATOM 3491 N N   . ASP C 3 29  ? 216.175 248.639 329.938 1.00 74.25  ? 29  ASP C N   1 
ATOM 3492 C CA  . ASP C 3 29  ? 215.575 247.574 329.134 1.00 76.67  ? 29  ASP C CA  1 
ATOM 3493 C C   . ASP C 3 29  ? 214.392 247.020 329.919 1.00 75.79  ? 29  ASP C C   1 
ATOM 3494 O O   . ASP C 3 29  ? 214.543 246.154 330.781 1.00 76.63  ? 29  ASP C O   1 
ATOM 3495 C CB  . ASP C 3 29  ? 216.594 246.488 328.813 1.00 80.44  ? 29  ASP C CB  1 
ATOM 3496 C CG  . ASP C 3 29  ? 216.048 245.439 327.863 1.00 83.14  ? 29  ASP C CG  1 
ATOM 3497 O OD1 . ASP C 3 29  ? 215.898 245.745 326.662 1.00 78.87  ? 29  ASP C OD1 1 
ATOM 3498 O OD2 . ASP C 3 29  ? 215.768 244.310 328.316 1.00 85.91  ? 29  ASP C OD2 1 
ATOM 3499 N N   . VAL C 3 30  ? 213.198 247.527 329.607 1.00 65.29  ? 30  VAL C N   1 
ATOM 3500 C CA  . VAL C 3 30  ? 212.014 247.164 330.373 1.00 61.50  ? 30  VAL C CA  1 
ATOM 3501 C C   . VAL C 3 30  ? 211.693 245.690 330.176 1.00 60.64  ? 30  VAL C C   1 
ATOM 3502 O O   . VAL C 3 30  ? 211.857 245.136 329.081 1.00 62.48  ? 30  VAL C O   1 
ATOM 3503 C CB  . VAL C 3 30  ? 210.827 248.049 329.964 1.00 62.26  ? 30  VAL C CB  1 
ATOM 3504 C CG1 . VAL C 3 30  ? 211.153 249.510 330.203 1.00 62.34  ? 30  VAL C CG1 1 
ATOM 3505 C CG2 . VAL C 3 30  ? 210.459 247.812 328.509 1.00 63.38  ? 30  VAL C CG2 1 
ATOM 3506 N N   . THR C 3 31  ? 211.228 245.050 331.241 1.00 56.92  ? 31  THR C N   1 
ATOM 3507 C CA  . THR C 3 31  ? 210.855 243.647 331.162 1.00 56.99  ? 31  THR C CA  1 
ATOM 3508 C C   . THR C 3 31  ? 209.726 243.477 330.151 1.00 61.49  ? 31  THR C C   1 
ATOM 3509 O O   . THR C 3 31  ? 208.689 244.142 330.273 1.00 71.64  ? 31  THR C O   1 
ATOM 3510 C CB  . THR C 3 31  ? 210.408 243.137 332.529 1.00 58.64  ? 31  THR C CB  1 
ATOM 3511 O OG1 . THR C 3 31  ? 209.382 243.992 333.043 1.00 67.00  ? 31  THR C OG1 1 
ATOM 3512 C CG2 . THR C 3 31  ? 211.570 243.120 333.499 1.00 58.20  ? 31  THR C CG2 1 
ATOM 3513 N N   . PRO C 3 32  ? 209.876 242.608 329.150 1.00 58.75  ? 32  PRO C N   1 
ATOM 3514 C CA  . PRO C 3 32  ? 208.848 242.508 328.120 1.00 64.94  ? 32  PRO C CA  1 
ATOM 3515 C C   . PRO C 3 32  ? 207.591 241.857 328.666 1.00 69.94  ? 32  PRO C C   1 
ATOM 3516 O O   . PRO C 3 32  ? 207.646 241.088 329.640 1.00 73.04  ? 32  PRO C O   1 
ATOM 3517 C CB  . PRO C 3 32  ? 209.512 241.633 327.043 1.00 66.16  ? 32  PRO C CB  1 
ATOM 3518 C CG  . PRO C 3 32  ? 210.465 240.793 327.802 1.00 64.71  ? 32  PRO C CG  1 
ATOM 3519 C CD  . PRO C 3 32  ? 210.973 241.652 328.923 1.00 58.62  ? 32  PRO C CD  1 
ATOM 3520 N N   . PRO C 3 33  ? 206.430 242.139 328.076 1.00 65.15  ? 33  PRO C N   1 
ATOM 3521 C CA  . PRO C 3 33  ? 205.217 241.413 328.462 1.00 66.93  ? 33  PRO C CA  1 
ATOM 3522 C C   . PRO C 3 33  ? 205.285 239.961 328.020 1.00 65.28  ? 33  PRO C C   1 
ATOM 3523 O O   . PRO C 3 33  ? 205.929 239.623 327.025 1.00 70.62  ? 33  PRO C O   1 
ATOM 3524 C CB  . PRO C 3 33  ? 204.105 242.169 327.731 1.00 67.13  ? 33  PRO C CB  1 
ATOM 3525 C CG  . PRO C 3 33  ? 204.779 242.764 326.552 1.00 68.08  ? 33  PRO C CG  1 
ATOM 3526 C CD  . PRO C 3 33  ? 206.171 243.106 326.997 1.00 60.49  ? 33  PRO C CD  1 
ATOM 3527 N N   . ILE C 3 34  ? 204.601 239.098 328.769 1.00 62.69  ? 34  ILE C N   1 
ATOM 3528 C CA  . ILE C 3 34  ? 204.676 237.661 328.542 1.00 68.48  ? 34  ILE C CA  1 
ATOM 3529 C C   . ILE C 3 34  ? 203.324 237.076 328.139 1.00 69.47  ? 34  ILE C C   1 
ATOM 3530 O O   . ILE C 3 34  ? 203.122 235.872 328.236 1.00 67.53  ? 34  ILE C O   1 
ATOM 3531 C CB  . ILE C 3 34  ? 205.241 236.933 329.776 1.00 65.56  ? 34  ILE C CB  1 
ATOM 3532 C CG1 . ILE C 3 34  ? 204.348 237.169 330.994 1.00 66.88  ? 34  ILE C CG1 1 
ATOM 3533 C CG2 . ILE C 3 34  ? 206.657 237.398 330.045 1.00 65.34  ? 34  ILE C CG2 1 
ATOM 3534 C CD1 . ILE C 3 34  ? 204.742 236.353 332.198 1.00 65.28  ? 34  ILE C CD1 1 
ATOM 3535 N N   . ASP C 3 35  ? 202.392 237.911 327.685 1.00 67.65  ? 35  ASP C N   1 
ATOM 3536 C CA  . ASP C 3 35  ? 201.129 237.432 327.129 1.00 68.24  ? 35  ASP C CA  1 
ATOM 3537 C C   . ASP C 3 35  ? 200.346 236.620 328.164 1.00 65.56  ? 35  ASP C C   1 
ATOM 3538 O O   . ASP C 3 35  ? 200.061 235.436 327.984 1.00 62.11  ? 35  ASP C O   1 
ATOM 3539 C CB  . ASP C 3 35  ? 201.390 236.609 325.863 1.00 69.74  ? 35  ASP C CB  1 
ATOM 3540 C CG  . ASP C 3 35  ? 200.118 236.109 325.216 1.00 73.30  ? 35  ASP C CG  1 
ATOM 3541 O OD1 . ASP C 3 35  ? 199.024 236.535 325.639 1.00 73.95  ? 35  ASP C OD1 1 
ATOM 3542 O OD2 . ASP C 3 35  ? 200.214 235.284 324.283 1.00 73.20  ? 35  ASP C OD2 1 
ATOM 3543 N N   . ILE C 3 36  ? 200.005 237.282 329.262 1.00 55.45  ? 36  ILE C N   1 
ATOM 3544 C CA  . ILE C 3 36  ? 199.190 236.634 330.296 1.00 47.52  ? 36  ILE C CA  1 
ATOM 3545 C C   . ILE C 3 36  ? 197.767 236.468 329.776 1.00 46.51  ? 36  ILE C C   1 
ATOM 3546 O O   . ILE C 3 36  ? 197.239 237.394 329.136 1.00 56.57  ? 36  ILE C O   1 
ATOM 3547 C CB  . ILE C 3 36  ? 199.211 237.460 331.584 1.00 47.34  ? 36  ILE C CB  1 
ATOM 3548 C CG1 . ILE C 3 36  ? 200.624 237.518 332.165 1.00 42.44  ? 36  ILE C CG1 1 
ATOM 3549 C CG2 . ILE C 3 36  ? 198.248 236.878 332.605 1.00 49.14  ? 36  ILE C CG2 1 
ATOM 3550 C CD1 . ILE C 3 36  ? 201.448 238.675 331.661 1.00 47.84  ? 36  ILE C CD1 1 
ATOM 3551 N N   . PRO C 3 37  ? 197.107 235.335 330.009 1.00 49.98  ? 37  PRO C N   1 
ATOM 3552 C CA  . PRO C 3 37  ? 195.711 235.208 329.581 1.00 54.87  ? 37  PRO C CA  1 
ATOM 3553 C C   . PRO C 3 37  ? 194.803 236.180 330.317 1.00 53.69  ? 37  PRO C C   1 
ATOM 3554 O O   . PRO C 3 37  ? 195.034 236.525 331.477 1.00 55.72  ? 37  PRO C O   1 
ATOM 3555 C CB  . PRO C 3 37  ? 195.363 233.755 329.925 1.00 50.64  ? 37  PRO C CB  1 
ATOM 3556 C CG  . PRO C 3 37  ? 196.661 233.055 329.989 1.00 51.72  ? 37  PRO C CG  1 
ATOM 3557 C CD  . PRO C 3 37  ? 197.634 234.058 330.518 1.00 57.92  ? 37  PRO C CD  1 
ATOM 3558 N N   . GLY C 3 38  ? 193.754 236.616 329.626 1.00 53.97  ? 38  GLY C N   1 
ATOM 3559 C CA  . GLY C 3 38  ? 192.716 237.416 330.246 1.00 58.40  ? 38  GLY C CA  1 
ATOM 3560 C C   . GLY C 3 38  ? 192.940 238.910 330.167 1.00 58.26  ? 38  GLY C C   1 
ATOM 3561 O O   . GLY C 3 38  ? 192.875 239.603 331.185 1.00 53.70  ? 38  GLY C O   1 
ATOM 3562 N N   . GLU C 3 39  ? 193.193 239.424 328.967 1.00 58.40  ? 39  GLU C N   1 
ATOM 3563 C CA  . GLU C 3 39  ? 193.404 240.850 328.773 1.00 53.80  ? 39  GLU C CA  1 
ATOM 3564 C C   . GLU C 3 39  ? 192.085 241.539 328.458 1.00 52.84  ? 39  GLU C C   1 
ATOM 3565 O O   . GLU C 3 39  ? 191.245 240.998 327.735 1.00 56.43  ? 39  GLU C O   1 
ATOM 3566 C CB  . GLU C 3 39  ? 194.402 241.106 327.643 1.00 57.28  ? 39  GLU C CB  1 
ATOM 3567 C CG  . GLU C 3 39  ? 194.847 242.554 327.553 1.00 61.24  ? 39  GLU C CG  1 
ATOM 3568 C CD  . GLU C 3 39  ? 195.981 242.758 326.576 1.00 62.02  ? 39  GLU C CD  1 
ATOM 3569 O OE1 . GLU C 3 39  ? 196.336 241.796 325.867 1.00 65.74  ? 39  GLU C OE1 1 
ATOM 3570 O OE2 . GLU C 3 39  ? 196.521 243.881 326.519 1.00 55.88  ? 39  GLU C OE2 1 
ATOM 3571 N N   . VAL C 3 40  ? 191.913 242.739 329.002 1.00 50.49  ? 40  VAL C N   1 
ATOM 3572 C CA  . VAL C 3 40  ? 190.717 243.546 328.795 1.00 46.94  ? 40  VAL C CA  1 
ATOM 3573 C C   . VAL C 3 40  ? 191.100 244.756 327.958 1.00 57.70  ? 40  VAL C C   1 
ATOM 3574 O O   . VAL C 3 40  ? 192.019 245.501 328.318 1.00 61.73  ? 40  VAL C O   1 
ATOM 3575 C CB  . VAL C 3 40  ? 190.095 243.980 330.130 1.00 36.64  ? 40  VAL C CB  1 
ATOM 3576 C CG1 . VAL C 3 40  ? 188.716 244.563 329.904 1.00 53.19  ? 40  VAL C CG1 1 
ATOM 3577 C CG2 . VAL C 3 40  ? 190.035 242.810 331.082 1.00 47.56  ? 40  VAL C CG2 1 
ATOM 3578 N N   . LYS C 3 41  ? 190.399 244.952 326.845 1.00 60.01  ? 41  LYS C N   1 
ATOM 3579 C CA  . LYS C 3 41  ? 190.650 246.078 325.955 1.00 60.16  ? 41  LYS C CA  1 
ATOM 3580 C C   . LYS C 3 41  ? 189.734 247.261 326.240 1.00 62.84  ? 41  LYS C C   1 
ATOM 3581 O O   . LYS C 3 41  ? 190.194 248.404 326.284 1.00 70.23  ? 41  LYS C O   1 
ATOM 3582 C CB  . LYS C 3 41  ? 190.490 245.636 324.498 1.00 60.29  ? 41  LYS C CB  1 
ATOM 3583 C CG  . LYS C 3 41  ? 191.517 244.616 324.045 1.00 59.43  ? 41  LYS C CG  1 
ATOM 3584 C CD  . LYS C 3 41  ? 192.908 245.215 323.987 1.00 60.44  ? 41  LYS C CD  1 
ATOM 3585 C CE  . LYS C 3 41  ? 193.882 244.281 323.292 1.00 64.41  ? 41  LYS C CE  1 
ATOM 3586 N NZ  . LYS C 3 41  ? 195.227 244.899 323.139 1.00 65.78  ? 41  LYS C NZ  1 
ATOM 3587 N N   . ASN C 3 42  ? 188.442 247.011 326.428 1.00 59.14  ? 42  ASN C N   1 
ATOM 3588 C CA  . ASN C 3 42  ? 187.472 248.052 326.730 1.00 58.82  ? 42  ASN C CA  1 
ATOM 3589 C C   . ASN C 3 42  ? 186.716 247.687 327.995 1.00 56.18  ? 42  ASN C C   1 
ATOM 3590 O O   . ASN C 3 42  ? 186.383 246.519 328.214 1.00 66.75  ? 42  ASN C O   1 
ATOM 3591 C CB  . ASN C 3 42  ? 186.488 248.246 325.576 1.00 56.23  ? 42  ASN C CB  1 
ATOM 3592 C CG  . ASN C 3 42  ? 187.165 248.713 324.306 1.00 62.47  ? 42  ASN C CG  1 
ATOM 3593 O OD1 . ASN C 3 42  ? 188.282 249.224 324.336 1.00 66.89  ? 42  ASN C OD1 1 
ATOM 3594 N ND2 . ASN C 3 42  ? 186.489 248.543 323.179 1.00 63.62  ? 42  ASN C ND2 1 
ATOM 3595 N N   . MET C 3 43  ? 186.439 248.690 328.828 1.00 53.24  ? 43  MET C N   1 
ATOM 3596 C CA  . MET C 3 43  ? 185.686 248.438 330.047 1.00 56.05  ? 43  MET C CA  1 
ATOM 3597 C C   . MET C 3 43  ? 184.310 247.861 329.754 1.00 61.96  ? 43  MET C C   1 
ATOM 3598 O O   . MET C 3 43  ? 183.730 247.200 330.621 1.00 73.15  ? 43  MET C O   1 
ATOM 3599 C CB  . MET C 3 43  ? 185.550 249.724 330.857 1.00 51.66  ? 43  MET C CB  1 
ATOM 3600 C CG  . MET C 3 43  ? 186.867 250.255 331.376 1.00 55.94  ? 43  MET C CG  1 
ATOM 3601 S SD  . MET C 3 43  ? 187.662 249.126 332.527 1.00 78.73  ? 43  MET C SD  1 
ATOM 3602 C CE  . MET C 3 43  ? 186.483 249.136 333.873 1.00 63.29  ? 43  MET C CE  1 
ATOM 3603 N N   . MET C 3 44  ? 183.775 248.084 328.554 1.00 53.16  ? 44  MET C N   1 
ATOM 3604 C CA  . MET C 3 44  ? 182.515 247.446 328.197 1.00 61.01  ? 44  MET C CA  1 
ATOM 3605 C C   . MET C 3 44  ? 182.639 245.931 328.217 1.00 69.12  ? 44  MET C C   1 
ATOM 3606 O O   . MET C 3 44  ? 181.652 245.233 328.470 1.00 75.33  ? 44  MET C O   1 
ATOM 3607 C CB  . MET C 3 44  ? 182.052 247.919 326.821 1.00 62.50  ? 44  MET C CB  1 
ATOM 3608 C CG  . MET C 3 44  ? 181.635 249.375 326.767 1.00 62.51  ? 44  MET C CG  1 
ATOM 3609 S SD  . MET C 3 44  ? 180.200 249.732 327.792 1.00 74.84  ? 44  MET C SD  1 
ATOM 3610 C CE  . MET C 3 44  ? 180.971 250.292 329.307 1.00 64.26  ? 44  MET C CE  1 
ATOM 3611 N N   . GLU C 3 45  ? 183.839 245.401 327.973 1.00 70.76  ? 45  GLU C N   1 
ATOM 3612 C CA  . GLU C 3 45  ? 184.023 243.958 328.043 1.00 62.28  ? 45  GLU C CA  1 
ATOM 3613 C C   . GLU C 3 45  ? 183.781 243.426 329.445 1.00 58.02  ? 45  GLU C C   1 
ATOM 3614 O O   . GLU C 3 45  ? 183.605 242.216 329.614 1.00 64.15  ? 45  GLU C O   1 
ATOM 3615 C CB  . GLU C 3 45  ? 185.426 243.577 327.577 1.00 64.30  ? 45  GLU C CB  1 
ATOM 3616 C CG  . GLU C 3 45  ? 185.686 243.907 326.116 1.00 75.76  ? 45  GLU C CG  1 
ATOM 3617 C CD  . GLU C 3 45  ? 186.908 243.204 325.558 1.00 76.04  ? 45  GLU C CD  1 
ATOM 3618 O OE1 . GLU C 3 45  ? 187.398 242.253 326.201 1.00 72.74  ? 45  GLU C OE1 1 
ATOM 3619 O OE2 . GLU C 3 45  ? 187.377 243.602 324.471 1.00 73.50  ? 45  GLU C OE2 1 
ATOM 3620 N N   . LEU C 3 46  ? 183.773 244.296 330.453 1.00 56.10  ? 46  LEU C N   1 
ATOM 3621 C CA  . LEU C 3 46  ? 183.374 243.892 331.793 1.00 57.19  ? 46  LEU C CA  1 
ATOM 3622 C C   . LEU C 3 46  ? 181.872 243.985 331.997 1.00 58.69  ? 46  LEU C C   1 
ATOM 3623 O O   . LEU C 3 46  ? 181.311 243.207 332.774 1.00 64.02  ? 46  LEU C O   1 
ATOM 3624 C CB  . LEU C 3 46  ? 184.074 244.756 332.842 1.00 53.78  ? 46  LEU C CB  1 
ATOM 3625 C CG  . LEU C 3 46  ? 185.593 244.850 332.747 1.00 57.42  ? 46  LEU C CG  1 
ATOM 3626 C CD1 . LEU C 3 46  ? 186.140 245.523 333.986 1.00 61.84  ? 46  LEU C CD1 1 
ATOM 3627 C CD2 . LEU C 3 46  ? 186.215 243.484 332.561 1.00 59.79  ? 46  LEU C CD2 1 
ATOM 3628 N N   . ALA C 3 47  ? 181.210 244.926 331.325 1.00 59.28  ? 47  ALA C N   1 
ATOM 3629 C CA  . ALA C 3 47  ? 179.763 245.036 331.451 1.00 60.12  ? 47  ALA C CA  1 
ATOM 3630 C C   . ALA C 3 47  ? 179.065 243.809 330.880 1.00 62.19  ? 47  ALA C C   1 
ATOM 3631 O O   . ALA C 3 47  ? 178.106 243.303 331.472 1.00 70.31  ? 47  ALA C O   1 
ATOM 3632 C CB  . ALA C 3 47  ? 179.272 246.302 330.755 1.00 60.83  ? 47  ALA C CB  1 
ATOM 3633 N N   . GLU C 3 48  ? 179.542 243.307 329.741 1.00 60.53  ? 48  GLU C N   1 
ATOM 3634 C CA  . GLU C 3 48  ? 178.856 242.213 329.067 1.00 66.22  ? 48  GLU C CA  1 
ATOM 3635 C C   . GLU C 3 48  ? 178.787 240.954 329.916 1.00 67.34  ? 48  GLU C C   1 
ATOM 3636 O O   . GLU C 3 48  ? 177.961 240.079 329.638 1.00 64.94  ? 48  GLU C O   1 
ATOM 3637 C CB  . GLU C 3 48  ? 179.552 241.899 327.747 1.00 66.79  ? 48  GLU C CB  1 
ATOM 3638 C CG  . GLU C 3 48  ? 179.558 243.053 326.772 1.00 68.21  ? 48  GLU C CG  1 
ATOM 3639 C CD  . GLU C 3 48  ? 180.265 242.709 325.483 1.00 75.59  ? 48  GLU C CD  1 
ATOM 3640 O OE1 . GLU C 3 48  ? 180.762 241.571 325.367 1.00 74.55  ? 48  GLU C OE1 1 
ATOM 3641 O OE2 . GLU C 3 48  ? 180.326 243.575 324.586 1.00 75.01  ? 48  GLU C OE2 1 
ATOM 3642 N N   . ILE C 3 49  ? 179.635 240.832 330.935 1.00 61.79  ? 49  ILE C N   1 
ATOM 3643 C CA  . ILE C 3 49  ? 179.607 239.652 331.787 1.00 59.83  ? 49  ILE C CA  1 
ATOM 3644 C C   . ILE C 3 49  ? 178.349 239.683 332.643 1.00 61.37  ? 49  ILE C C   1 
ATOM 3645 O O   . ILE C 3 49  ? 178.051 240.686 333.303 1.00 59.33  ? 49  ILE C O   1 
ATOM 3646 C CB  . ILE C 3 49  ? 180.871 239.585 332.653 1.00 61.33  ? 49  ILE C CB  1 
ATOM 3647 C CG1 . ILE C 3 49  ? 182.105 239.409 331.768 1.00 62.71  ? 49  ILE C CG1 1 
ATOM 3648 C CG2 . ILE C 3 49  ? 180.760 238.448 333.645 1.00 63.68  ? 49  ILE C CG2 1 
ATOM 3649 C CD1 . ILE C 3 49  ? 183.403 239.732 332.467 1.00 62.16  ? 49  ILE C CD1 1 
ATOM 3650 N N   . ASP C 3 50  ? 177.609 238.580 332.639 1.00 63.34  ? 50  ASP C N   1 
ATOM 3651 C CA  . ASP C 3 50  ? 176.317 238.510 333.314 1.00 62.07  ? 50  ASP C CA  1 
ATOM 3652 C C   . ASP C 3 50  ? 176.534 238.412 334.815 1.00 59.03  ? 50  ASP C C   1 
ATOM 3653 O O   . ASP C 3 50  ? 176.788 237.332 335.350 1.00 65.93  ? 50  ASP C O   1 
ATOM 3654 C CB  . ASP C 3 50  ? 175.521 237.317 332.802 1.00 67.90  ? 50  ASP C CB  1 
ATOM 3655 C CG  . ASP C 3 50  ? 175.369 237.325 331.300 1.00 75.41  ? 50  ASP C CG  1 
ATOM 3656 O OD1 . ASP C 3 50  ? 176.400 237.266 330.598 1.00 71.75  ? 50  ASP C OD1 1 
ATOM 3657 O OD2 . ASP C 3 50  ? 174.218 237.388 330.820 1.00 77.15  ? 50  ASP C OD2 1 
ATOM 3658 N N   . THR C 3 51  ? 176.430 239.543 335.504 1.00 49.99  ? 51  THR C N   1 
ATOM 3659 C CA  . THR C 3 51  ? 176.502 239.564 336.953 1.00 50.63  ? 51  THR C CA  1 
ATOM 3660 C C   . THR C 3 51  ? 175.112 239.325 337.532 1.00 45.59  ? 51  THR C C   1 
ATOM 3661 O O   . THR C 3 51  ? 174.145 239.095 336.806 1.00 54.26  ? 51  THR C O   1 
ATOM 3662 C CB  . THR C 3 51  ? 177.087 240.885 337.437 1.00 56.98  ? 51  THR C CB  1 
ATOM 3663 O OG1 . THR C 3 51  ? 176.261 241.965 336.991 1.00 68.19  ? 51  THR C OG1 1 
ATOM 3664 C CG2 . THR C 3 51  ? 178.491 241.070 336.894 1.00 57.45  ? 51  THR C CG2 1 
ATOM 3665 N N   . MET C 3 52  ? 175.003 239.391 338.853 1.00 49.52  ? 52  MET C N   1 
ATOM 3666 C CA  . MET C 3 52  ? 173.792 239.008 339.560 1.00 50.91  ? 52  MET C CA  1 
ATOM 3667 C C   . MET C 3 52  ? 173.121 240.232 340.171 1.00 54.97  ? 52  MET C C   1 
ATOM 3668 O O   . MET C 3 52  ? 173.787 241.178 340.596 1.00 63.04  ? 52  MET C O   1 
ATOM 3669 C CB  . MET C 3 52  ? 174.111 237.988 340.652 1.00 56.93  ? 52  MET C CB  1 
ATOM 3670 C CG  . MET C 3 52  ? 172.899 237.307 341.244 1.00 57.16  ? 52  MET C CG  1 
ATOM 3671 S SD  . MET C 3 52  ? 173.351 236.041 342.441 1.00 71.04  ? 52  MET C SD  1 
ATOM 3672 C CE  . MET C 3 52  ? 173.248 234.579 341.426 1.00 60.07  ? 52  MET C CE  1 
ATOM 3673 N N   . ILE C 3 53  ? 171.798 240.200 340.213 1.00 54.68  ? 53  ILE C N   1 
ATOM 3674 C CA  . ILE C 3 53  ? 170.983 241.331 340.652 1.00 51.44  ? 53  ILE C CA  1 
ATOM 3675 C C   . ILE C 3 53  ? 170.578 241.102 342.104 1.00 53.39  ? 53  ILE C C   1 
ATOM 3676 O O   . ILE C 3 53  ? 170.054 240.027 342.420 1.00 65.93  ? 53  ILE C O   1 
ATOM 3677 C CB  . ILE C 3 53  ? 169.736 241.500 339.768 1.00 48.53  ? 53  ILE C CB  1 
ATOM 3678 C CG1 . ILE C 3 53  ? 170.124 241.506 338.293 1.00 49.37  ? 53  ILE C CG1 1 
ATOM 3679 C CG2 . ILE C 3 53  ? 169.009 242.782 340.121 1.00 54.38  ? 53  ILE C CG2 1 
ATOM 3680 C CD1 . ILE C 3 53  ? 168.947 241.621 337.366 1.00 60.16  ? 53  ILE C CD1 1 
ATOM 3681 N N   . PRO C 3 54  ? 170.797 242.061 343.003 1.00 56.08  ? 54  PRO C N   1 
ATOM 3682 C CA  . PRO C 3 54  ? 170.279 241.923 344.379 1.00 58.69  ? 54  PRO C CA  1 
ATOM 3683 C C   . PRO C 3 54  ? 168.812 242.326 344.494 1.00 63.22  ? 54  PRO C C   1 
ATOM 3684 O O   . PRO C 3 54  ? 168.451 243.443 344.854 1.00 68.73  ? 54  PRO C O   1 
ATOM 3685 C CB  . PRO C 3 54  ? 171.197 242.852 345.174 1.00 63.06  ? 54  PRO C CB  1 
ATOM 3686 C CG  . PRO C 3 54  ? 171.560 243.908 344.213 1.00 70.57  ? 54  PRO C CG  1 
ATOM 3687 C CD  . PRO C 3 54  ? 171.648 243.253 342.863 1.00 69.62  ? 54  PRO C CD  1 
ATOM 3688 N N   . PHE C 3 55  ? 167.930 241.375 344.182 1.00 67.25  ? 55  PHE C N   1 
ATOM 3689 C CA  . PHE C 3 55  ? 166.504 241.677 344.117 1.00 63.71  ? 55  PHE C CA  1 
ATOM 3690 C C   . PHE C 3 55  ? 165.962 242.142 345.461 1.00 67.36  ? 55  PHE C C   1 
ATOM 3691 O O   . PHE C 3 55  ? 165.157 243.077 345.521 1.00 77.62  ? 55  PHE C O   1 
ATOM 3692 C CB  . PHE C 3 55  ? 165.733 240.450 343.635 1.00 57.88  ? 55  PHE C CB  1 
ATOM 3693 C CG  . PHE C 3 55  ? 165.802 240.233 342.153 1.00 61.32  ? 55  PHE C CG  1 
ATOM 3694 C CD1 . PHE C 3 55  ? 165.575 241.274 341.273 1.00 60.75  ? 55  PHE C CD1 1 
ATOM 3695 C CD2 . PHE C 3 55  ? 166.092 238.984 341.640 1.00 66.81  ? 55  PHE C CD2 1 
ATOM 3696 C CE1 . PHE C 3 55  ? 165.637 241.074 339.915 1.00 62.00  ? 55  PHE C CE1 1 
ATOM 3697 C CE2 . PHE C 3 55  ? 166.154 238.779 340.282 1.00 67.75  ? 55  PHE C CE2 1 
ATOM 3698 C CZ  . PHE C 3 55  ? 165.926 239.825 339.419 1.00 69.22  ? 55  PHE C CZ  1 
ATOM 3699 N N   . ASP C 3 56  ? 166.374 241.503 346.547 1.00 86.75  ? 56  ASP C N   1 
ATOM 3700 C CA  . ASP C 3 56  ? 165.808 241.765 347.868 1.00 90.79  ? 56  ASP C CA  1 
ATOM 3701 C C   . ASP C 3 56  ? 166.842 242.503 348.711 1.00 92.17  ? 56  ASP C C   1 
ATOM 3702 O O   . ASP C 3 56  ? 167.733 241.883 349.297 1.00 93.66  ? 56  ASP C O   1 
ATOM 3703 C CB  . ASP C 3 56  ? 165.377 240.463 348.533 1.00 94.89  ? 56  ASP C CB  1 
ATOM 3704 C CG  . ASP C 3 56  ? 164.498 240.692 349.742 1.00 97.25  ? 56  ASP C CG  1 
ATOM 3705 O OD1 . ASP C 3 56  ? 164.724 241.685 350.464 1.00 97.01  ? 56  ASP C OD1 1 
ATOM 3706 O OD2 . ASP C 3 56  ? 163.578 239.879 349.968 1.00 97.00  ? 56  ASP C OD2 1 
ATOM 3707 N N   . LEU C 3 57  ? 166.709 243.829 348.784 1.00 90.62  ? 57  LEU C N   1 
ATOM 3708 C CA  . LEU C 3 57  ? 167.573 244.665 349.609 1.00 93.80  ? 57  LEU C CA  1 
ATOM 3709 C C   . LEU C 3 57  ? 166.977 244.947 350.983 1.00 94.27  ? 57  LEU C C   1 
ATOM 3710 O O   . LEU C 3 57  ? 167.273 245.990 351.581 1.00 88.52  ? 57  LEU C O   1 
ATOM 3711 C CB  . LEU C 3 57  ? 167.875 245.981 348.891 1.00 89.34  ? 57  LEU C CB  1 
ATOM 3712 C CG  . LEU C 3 57  ? 168.710 245.907 347.613 1.00 87.28  ? 57  LEU C CG  1 
ATOM 3713 C CD1 . LEU C 3 57  ? 168.906 247.299 347.044 1.00 82.89  ? 57  LEU C CD1 1 
ATOM 3714 C CD2 . LEU C 3 57  ? 170.052 245.251 347.878 1.00 88.50  ? 57  LEU C CD2 1 
ATOM 3715 N N   . SER C 3 58  ? 166.147 244.045 351.502 1.00 112.65 ? 58  SER C N   1 
ATOM 3716 C CA  . SER C 3 58  ? 165.505 244.279 352.787 1.00 111.22 ? 58  SER C CA  1 
ATOM 3717 C C   . SER C 3 58  ? 166.551 244.434 353.885 1.00 113.12 ? 58  SER C C   1 
ATOM 3718 O O   . SER C 3 58  ? 167.675 243.936 353.782 1.00 111.35 ? 58  SER C O   1 
ATOM 3719 C CB  . SER C 3 58  ? 164.553 243.132 353.125 1.00 111.60 ? 58  SER C CB  1 
ATOM 3720 O OG  . SER C 3 58  ? 165.227 241.888 353.098 1.00 112.57 ? 58  SER C OG  1 
ATOM 3721 N N   . ALA C 3 59  ? 166.164 245.139 354.951 1.00 114.84 ? 59  ALA C N   1 
ATOM 3722 C CA  . ALA C 3 59  ? 167.115 245.484 356.003 1.00 115.21 ? 59  ALA C CA  1 
ATOM 3723 C C   . ALA C 3 59  ? 167.801 244.252 356.580 1.00 117.02 ? 59  ALA C C   1 
ATOM 3724 O O   . ALA C 3 59  ? 168.967 244.326 356.984 1.00 113.22 ? 59  ALA C O   1 
ATOM 3725 C CB  . ALA C 3 59  ? 166.406 246.260 357.112 1.00 112.09 ? 59  ALA C CB  1 
ATOM 3726 N N   . THR C 3 60  ? 167.104 243.119 356.633 1.00 121.86 ? 60  THR C N   1 
ATOM 3727 C CA  . THR C 3 60  ? 167.678 241.906 357.200 1.00 120.54 ? 60  THR C CA  1 
ATOM 3728 C C   . THR C 3 60  ? 168.416 241.079 356.152 1.00 120.56 ? 60  THR C C   1 
ATOM 3729 O O   . THR C 3 60  ? 169.572 240.700 356.358 1.00 116.36 ? 60  THR C O   1 
ATOM 3730 C CB  . THR C 3 60  ? 166.581 241.061 357.856 1.00 121.01 ? 60  THR C CB  1 
ATOM 3731 O OG1 . THR C 3 60  ? 165.595 240.707 356.877 1.00 120.64 ? 60  THR C OG1 1 
ATOM 3732 C CG2 . THR C 3 60  ? 165.917 241.833 358.988 1.00 118.92 ? 60  THR C CG2 1 
ATOM 3733 N N   . LYS C 3 61  ? 167.763 240.796 355.022 1.00 115.53 ? 61  LYS C N   1 
ATOM 3734 C CA  . LYS C 3 61  ? 168.393 239.971 353.998 1.00 113.12 ? 61  LYS C CA  1 
ATOM 3735 C C   . LYS C 3 61  ? 169.585 240.671 353.361 1.00 112.55 ? 61  LYS C C   1 
ATOM 3736 O O   . LYS C 3 61  ? 170.519 240.004 352.904 1.00 111.80 ? 61  LYS C O   1 
ATOM 3737 C CB  . LYS C 3 61  ? 167.373 239.589 352.927 1.00 109.54 ? 61  LYS C CB  1 
ATOM 3738 C CG  . LYS C 3 61  ? 166.206 238.773 353.457 1.00 110.54 ? 61  LYS C CG  1 
ATOM 3739 C CD  . LYS C 3 61  ? 165.219 238.428 352.356 1.00 110.82 ? 61  LYS C CD  1 
ATOM 3740 C CE  . LYS C 3 61  ? 164.144 237.476 352.852 1.00 109.63 ? 61  LYS C CE  1 
ATOM 3741 N NZ  . LYS C 3 61  ? 163.397 238.036 354.009 1.00 111.64 ? 61  LYS C NZ  1 
ATOM 3742 N N   . LYS C 3 62  ? 169.576 242.001 353.317 1.00 107.50 ? 62  LYS C N   1 
ATOM 3743 C CA  . LYS C 3 62  ? 170.696 242.723 352.737 1.00 106.68 ? 62  LYS C CA  1 
ATOM 3744 C C   . LYS C 3 62  ? 171.989 242.361 353.462 1.00 104.44 ? 62  LYS C C   1 
ATOM 3745 O O   . LYS C 3 62  ? 171.984 241.775 354.548 1.00 103.41 ? 62  LYS C O   1 
ATOM 3746 C CB  . LYS C 3 62  ? 170.461 244.233 352.803 1.00 104.94 ? 62  LYS C CB  1 
ATOM 3747 C CG  . LYS C 3 62  ? 170.518 244.814 354.206 1.00 105.38 ? 62  LYS C CG  1 
ATOM 3748 C CD  . LYS C 3 62  ? 170.217 246.302 354.203 1.00 104.00 ? 62  LYS C CD  1 
ATOM 3749 C CE  . LYS C 3 62  ? 170.468 246.922 355.569 1.00 104.46 ? 62  LYS C CE  1 
ATOM 3750 N NZ  . LYS C 3 62  ? 170.156 248.377 355.590 1.00 102.47 ? 62  LYS C NZ  1 
ATOM 3751 N N   . ASN C 3 63  ? 173.109 242.713 352.840 1.00 107.42 ? 63  ASN C N   1 
ATOM 3752 C CA  . ASN C 3 63  ? 174.444 242.444 353.362 1.00 111.47 ? 63  ASN C CA  1 
ATOM 3753 C C   . ASN C 3 63  ? 174.746 240.954 353.458 1.00 109.43 ? 63  ASN C C   1 
ATOM 3754 O O   . ASN C 3 63  ? 175.729 240.567 354.100 1.00 107.97 ? 63  ASN C O   1 
ATOM 3755 C CB  . ASN C 3 63  ? 174.646 243.098 354.735 1.00 110.38 ? 63  ASN C CB  1 
ATOM 3756 C CG  . ASN C 3 63  ? 174.253 244.560 354.748 1.00 108.09 ? 63  ASN C CG  1 
ATOM 3757 O OD1 . ASN C 3 63  ? 174.356 245.252 353.736 1.00 109.07 ? 63  ASN C OD1 1 
ATOM 3758 N ND2 . ASN C 3 63  ? 173.798 245.039 355.899 1.00 105.80 ? 63  ASN C ND2 1 
ATOM 3759 N N   . THR C 3 64  ? 173.927 240.105 352.841 1.00 101.40 ? 64  THR C N   1 
ATOM 3760 C CA  . THR C 3 64  ? 174.108 238.663 352.903 1.00 102.54 ? 64  THR C CA  1 
ATOM 3761 C C   . THR C 3 64  ? 173.827 238.076 351.527 1.00 101.76 ? 64  THR C C   1 
ATOM 3762 O O   . THR C 3 64  ? 173.570 238.798 350.560 1.00 99.09  ? 64  THR C O   1 
ATOM 3763 C CB  . THR C 3 64  ? 173.199 238.033 353.964 1.00 102.01 ? 64  THR C CB  1 
ATOM 3764 O OG1 . THR C 3 64  ? 171.831 238.334 353.665 1.00 103.44 ? 64  THR C OG1 1 
ATOM 3765 C CG2 . THR C 3 64  ? 173.541 238.567 355.345 1.00 100.02 ? 64  THR C CG2 1 
ATOM 3766 N N   . MET C 3 65  ? 173.878 236.751 351.441 1.00 93.95  ? 65  MET C N   1 
ATOM 3767 C CA  . MET C 3 65  ? 173.609 236.058 350.190 1.00 92.67  ? 65  MET C CA  1 
ATOM 3768 C C   . MET C 3 65  ? 172.122 235.852 349.945 1.00 93.09  ? 65  MET C C   1 
ATOM 3769 O O   . MET C 3 65  ? 171.751 235.302 348.903 1.00 90.50  ? 65  MET C O   1 
ATOM 3770 C CB  . MET C 3 65  ? 174.324 234.706 350.183 1.00 92.92  ? 65  MET C CB  1 
ATOM 3771 C CG  . MET C 3 65  ? 174.627 234.182 348.792 1.00 92.79  ? 65  MET C CG  1 
ATOM 3772 S SD  . MET C 3 65  ? 175.529 232.621 348.803 1.00 109.83 ? 65  MET C SD  1 
ATOM 3773 C CE  . MET C 3 65  ? 176.988 233.055 349.748 1.00 91.91  ? 65  MET C CE  1 
ATOM 3774 N N   . GLU C 3 66  ? 171.269 236.275 350.876 1.00 91.81  ? 66  GLU C N   1 
ATOM 3775 C CA  . GLU C 3 66  ? 169.828 236.141 350.725 1.00 90.27  ? 66  GLU C CA  1 
ATOM 3776 C C   . GLU C 3 66  ? 169.227 237.213 349.830 1.00 90.94  ? 66  GLU C C   1 
ATOM 3777 O O   . GLU C 3 66  ? 168.062 237.087 349.440 1.00 93.18  ? 66  GLU C O   1 
ATOM 3778 C CB  . GLU C 3 66  ? 169.155 236.202 352.097 1.00 93.40  ? 66  GLU C CB  1 
ATOM 3779 C CG  . GLU C 3 66  ? 169.770 235.281 353.137 1.00 96.26  ? 66  GLU C CG  1 
ATOM 3780 C CD  . GLU C 3 66  ? 169.261 235.568 354.533 1.00 99.43  ? 66  GLU C CD  1 
ATOM 3781 O OE1 . GLU C 3 66  ? 168.189 236.196 354.657 1.00 98.60  ? 66  GLU C OE1 1 
ATOM 3782 O OE2 . GLU C 3 66  ? 169.936 235.173 355.508 1.00 96.86  ? 66  GLU C OE2 1 
ATOM 3783 N N   . MET C 3 67  ? 169.983 238.261 349.501 1.00 84.96  ? 67  MET C N   1 
ATOM 3784 C CA  . MET C 3 67  ? 169.418 239.362 348.731 1.00 85.23  ? 67  MET C CA  1 
ATOM 3785 C C   . MET C 3 67  ? 169.234 238.994 347.267 1.00 82.94  ? 67  MET C C   1 
ATOM 3786 O O   . MET C 3 67  ? 168.331 239.518 346.608 1.00 91.80  ? 67  MET C O   1 
ATOM 3787 C CB  . MET C 3 67  ? 170.316 240.595 348.845 1.00 85.33  ? 67  MET C CB  1 
ATOM 3788 C CG  . MET C 3 67  ? 171.660 240.452 348.147 1.00 88.39  ? 67  MET C CG  1 
ATOM 3789 S SD  . MET C 3 67  ? 172.661 241.946 348.215 1.00 95.65  ? 67  MET C SD  1 
ATOM 3790 C CE  . MET C 3 67  ? 173.246 241.886 349.901 1.00 87.12  ? 67  MET C CE  1 
ATOM 3791 N N   . TYR C 3 68  ? 170.070 238.102 346.742 1.00 56.69  ? 68  TYR C N   1 
ATOM 3792 C CA  . TYR C 3 68  ? 170.150 237.902 345.304 1.00 56.71  ? 68  TYR C CA  1 
ATOM 3793 C C   . TYR C 3 68  ? 169.052 237.013 344.742 1.00 64.00  ? 68  TYR C C   1 
ATOM 3794 O O   . TYR C 3 68  ? 168.886 236.975 343.519 1.00 65.46  ? 68  TYR C O   1 
ATOM 3795 C CB  . TYR C 3 68  ? 171.502 237.297 344.941 1.00 61.67  ? 68  TYR C CB  1 
ATOM 3796 C CG  . TYR C 3 68  ? 172.675 238.210 345.190 1.00 63.31  ? 68  TYR C CG  1 
ATOM 3797 C CD1 . TYR C 3 68  ? 173.303 238.245 346.421 1.00 59.77  ? 68  TYR C CD1 1 
ATOM 3798 C CD2 . TYR C 3 68  ? 173.158 239.033 344.188 1.00 67.19  ? 68  TYR C CD2 1 
ATOM 3799 C CE1 . TYR C 3 68  ? 174.372 239.076 346.649 1.00 60.90  ? 68  TYR C CE1 1 
ATOM 3800 C CE2 . TYR C 3 68  ? 174.226 239.866 344.406 1.00 63.32  ? 68  TYR C CE2 1 
ATOM 3801 C CZ  . TYR C 3 68  ? 174.830 239.884 345.636 1.00 65.83  ? 68  TYR C CZ  1 
ATOM 3802 O OH  . TYR C 3 68  ? 175.900 240.719 345.851 1.00 77.26  ? 68  TYR C OH  1 
ATOM 3803 N N   . ARG C 3 69  ? 168.306 236.304 345.581 1.00 72.36  ? 69  ARG C N   1 
ATOM 3804 C CA  . ARG C 3 69  ? 167.349 235.306 345.127 1.00 71.57  ? 69  ARG C CA  1 
ATOM 3805 C C   . ARG C 3 69  ? 165.958 235.651 345.632 1.00 74.38  ? 69  ARG C C   1 
ATOM 3806 O O   . ARG C 3 69  ? 165.795 236.089 346.775 1.00 74.46  ? 69  ARG C O   1 
ATOM 3807 C CB  . ARG C 3 69  ? 167.751 233.911 345.607 1.00 67.69  ? 69  ARG C CB  1 
ATOM 3808 C CG  . ARG C 3 69  ? 167.925 233.789 347.107 1.00 70.51  ? 69  ARG C CG  1 
ATOM 3809 C CD  . ARG C 3 69  ? 168.705 232.536 347.454 1.00 77.97  ? 69  ARG C CD  1 
ATOM 3810 N NE  . ARG C 3 69  ? 169.135 232.515 348.846 1.00 84.28  ? 69  ARG C NE  1 
ATOM 3811 C CZ  . ARG C 3 69  ? 168.394 232.083 349.857 1.00 82.26  ? 69  ARG C CZ  1 
ATOM 3812 N NH1 . ARG C 3 69  ? 167.159 231.645 349.673 1.00 74.10  ? 69  ARG C NH1 1 
ATOM 3813 N NH2 . ARG C 3 69  ? 168.904 232.091 351.084 1.00 80.18  ? 69  ARG C NH2 1 
ATOM 3814 N N   . VAL C 3 70  ? 164.955 235.450 344.779 1.00 69.85  ? 70  VAL C N   1 
ATOM 3815 C CA  . VAL C 3 70  ? 163.566 235.754 345.105 1.00 65.13  ? 70  VAL C CA  1 
ATOM 3816 C C   . VAL C 3 70  ? 162.821 234.442 345.295 1.00 68.02  ? 70  VAL C C   1 
ATOM 3817 O O   . VAL C 3 70  ? 162.942 233.529 344.471 1.00 71.13  ? 70  VAL C O   1 
ATOM 3818 C CB  . VAL C 3 70  ? 162.902 236.611 344.015 1.00 64.27  ? 70  VAL C CB  1 
ATOM 3819 C CG1 . VAL C 3 70  ? 161.483 236.968 344.420 1.00 67.36  ? 70  VAL C CG1 1 
ATOM 3820 C CG2 . VAL C 3 70  ? 163.714 237.863 343.761 1.00 72.17  ? 70  VAL C CG2 1 
ATOM 3821 N N   . ARG C 3 71  ? 162.052 234.352 346.377 1.00 72.81  ? 71  ARG C N   1 
ATOM 3822 C CA  . ARG C 3 71  ? 161.372 233.119 346.751 1.00 74.19  ? 71  ARG C CA  1 
ATOM 3823 C C   . ARG C 3 71  ? 160.003 233.060 346.086 1.00 76.79  ? 71  ARG C C   1 
ATOM 3824 O O   . ARG C 3 71  ? 159.183 233.967 346.259 1.00 78.69  ? 71  ARG C O   1 
ATOM 3825 C CB  . ARG C 3 71  ? 161.229 233.021 348.268 1.00 72.59  ? 71  ARG C CB  1 
ATOM 3826 C CG  . ARG C 3 71  ? 162.498 233.332 349.039 1.00 77.75  ? 71  ARG C CG  1 
ATOM 3827 C CD  . ARG C 3 71  ? 163.670 232.480 348.579 1.00 82.64  ? 71  ARG C CD  1 
ATOM 3828 N NE  . ARG C 3 71  ? 163.442 231.054 348.789 1.00 81.92  ? 71  ARG C NE  1 
ATOM 3829 C CZ  . ARG C 3 71  ? 163.790 230.389 349.882 1.00 83.97  ? 71  ARG C CZ  1 
ATOM 3830 N NH1 . ARG C 3 71  ? 164.376 230.991 350.904 1.00 83.39  ? 71  ARG C NH1 1 
ATOM 3831 N NH2 . ARG C 3 71  ? 163.542 229.085 349.954 1.00 82.54  ? 71  ARG C NH2 1 
ATOM 3832 N N   . LEU C 3 72  ? 159.755 231.988 345.337 1.00 70.58  ? 72  LEU C N   1 
ATOM 3833 C CA  . LEU C 3 72  ? 158.465 231.753 344.691 1.00 69.27  ? 72  LEU C CA  1 
ATOM 3834 C C   . LEU C 3 72  ? 157.685 230.776 345.564 1.00 76.06  ? 72  LEU C C   1 
ATOM 3835 O O   . LEU C 3 72  ? 157.770 229.561 345.397 1.00 75.75  ? 72  LEU C O   1 
ATOM 3836 C CB  . LEU C 3 72  ? 158.653 231.210 343.280 1.00 67.02  ? 72  LEU C CB  1 
ATOM 3837 C CG  . LEU C 3 72  ? 159.698 231.924 342.430 1.00 66.47  ? 72  LEU C CG  1 
ATOM 3838 C CD1 . LEU C 3 72  ? 159.601 231.474 340.987 1.00 65.18  ? 72  LEU C CD1 1 
ATOM 3839 C CD2 . LEU C 3 72  ? 159.535 233.422 342.539 1.00 70.45  ? 72  LEU C CD2 1 
ATOM 3840 N N   . SER C 3 73  ? 156.909 231.314 346.501 1.00 89.18  ? 73  SER C N   1 
ATOM 3841 C CA  . SER C 3 73  ? 156.116 230.466 347.380 1.00 85.66  ? 73  SER C CA  1 
ATOM 3842 C C   . SER C 3 73  ? 154.912 229.919 346.629 1.00 90.32  ? 73  SER C C   1 
ATOM 3843 O O   . SER C 3 73  ? 154.778 230.137 345.421 1.00 90.72  ? 73  SER C O   1 
ATOM 3844 C CB  . SER C 3 73  ? 155.668 231.243 348.617 1.00 88.13  ? 73  SER C CB  1 
ATOM 3845 O OG  . SER C 3 73  ? 154.836 230.443 349.436 1.00 91.26  ? 73  SER C OG  1 
ATOM 3846 N N   . ASP C 3 74  ? 154.030 229.207 347.331 1.00 99.64  ? 74  ASP C N   1 
ATOM 3847 C CA  . ASP C 3 74  ? 152.886 228.547 346.715 1.00 102.09 ? 74  ASP C CA  1 
ATOM 3848 C C   . ASP C 3 74  ? 151.629 228.820 347.545 1.00 100.54 ? 74  ASP C C   1 
ATOM 3849 O O   . ASP C 3 74  ? 150.847 227.926 347.857 1.00 98.46  ? 74  ASP C O   1 
ATOM 3850 C CB  . ASP C 3 74  ? 153.146 227.048 346.569 1.00 98.61  ? 74  ASP C CB  1 
ATOM 3851 C CG  . ASP C 3 74  ? 152.929 226.547 345.153 1.00 98.31  ? 74  ASP C CG  1 
ATOM 3852 O OD1 . ASP C 3 74  ? 152.959 227.364 344.209 1.00 94.04  ? 74  ASP C OD1 1 
ATOM 3853 O OD2 . ASP C 3 74  ? 152.724 225.327 344.985 1.00 98.93  ? 74  ASP C OD2 1 
ATOM 3854 N N   . LYS C 3 75  ? 151.421 230.086 347.908 1.00 105.89 ? 75  LYS C N   1 
ATOM 3855 C CA  . LYS C 3 75  ? 150.319 230.418 348.803 1.00 106.88 ? 75  LYS C CA  1 
ATOM 3856 C C   . LYS C 3 75  ? 149.431 231.521 348.221 1.00 106.21 ? 75  LYS C C   1 
ATOM 3857 O O   . LYS C 3 75  ? 148.462 231.196 347.522 1.00 103.26 ? 75  LYS C O   1 
ATOM 3858 C CB  . LYS C 3 75  ? 150.874 230.792 350.181 1.00 106.18 ? 75  LYS C CB  1 
ATOM 3859 C CG  . LYS C 3 75  ? 151.320 229.601 351.021 1.00 103.64 ? 75  LYS C CG  1 
ATOM 3860 C CD  . LYS C 3 75  ? 151.865 230.044 352.375 1.00 104.24 ? 75  LYS C CD  1 
ATOM 3861 C CE  . LYS C 3 75  ? 153.229 230.717 352.260 1.00 105.64 ? 75  LYS C CE  1 
ATOM 3862 N NZ  . LYS C 3 75  ? 154.354 229.759 352.447 1.00 107.00 ? 75  LYS C NZ  1 
ATOM 3863 N N   . PRO C 3 76  ? 149.692 232.829 348.465 1.00 109.36 ? 76  PRO C N   1 
ATOM 3864 C CA  . PRO C 3 76  ? 148.691 233.833 348.070 1.00 107.59 ? 76  PRO C CA  1 
ATOM 3865 C C   . PRO C 3 76  ? 148.490 233.952 346.565 1.00 107.28 ? 76  PRO C C   1 
ATOM 3866 O O   . PRO C 3 76  ? 147.366 233.804 346.075 1.00 106.70 ? 76  PRO C O   1 
ATOM 3867 C CB  . PRO C 3 76  ? 149.252 235.132 348.657 1.00 105.77 ? 76  PRO C CB  1 
ATOM 3868 C CG  . PRO C 3 76  ? 150.708 234.934 348.647 1.00 106.29 ? 76  PRO C CG  1 
ATOM 3869 C CD  . PRO C 3 76  ? 150.926 233.479 348.949 1.00 106.33 ? 76  PRO C CD  1 
ATOM 3870 N N   . HIS C 3 77  ? 149.568 234.203 345.822 1.00 98.07  ? 77  HIS C N   1 
ATOM 3871 C CA  . HIS C 3 77  ? 149.492 234.435 344.380 1.00 98.34  ? 77  HIS C CA  1 
ATOM 3872 C C   . HIS C 3 77  ? 148.410 235.462 344.049 1.00 100.84 ? 77  HIS C C   1 
ATOM 3873 O O   . HIS C 3 77  ? 147.468 235.195 343.301 1.00 99.26  ? 77  HIS C O   1 
ATOM 3874 C CB  . HIS C 3 77  ? 149.242 233.127 343.631 1.00 97.68  ? 77  HIS C CB  1 
ATOM 3875 C CG  . HIS C 3 77  ? 150.271 232.075 343.895 1.00 99.83  ? 77  HIS C CG  1 
ATOM 3876 N ND1 . HIS C 3 77  ? 150.137 230.776 343.455 1.00 97.92  ? 77  HIS C ND1 1 
ATOM 3877 C CD2 . HIS C 3 77  ? 151.452 232.130 344.555 1.00 95.86  ? 77  HIS C CD2 1 
ATOM 3878 C CE1 . HIS C 3 77  ? 151.191 230.076 343.832 1.00 96.48  ? 77  HIS C CE1 1 
ATOM 3879 N NE2 . HIS C 3 77  ? 152.004 230.874 344.500 1.00 97.74  ? 77  HIS C NE2 1 
ATOM 3880 N N   . THR C 3 78  ? 148.554 236.658 344.618 1.00 108.28 ? 78  THR C N   1 
ATOM 3881 C CA  . THR C 3 78  ? 147.545 237.698 344.455 1.00 107.62 ? 78  THR C CA  1 
ATOM 3882 C C   . THR C 3 78  ? 147.786 238.537 343.205 1.00 105.42 ? 78  THR C C   1 
ATOM 3883 O O   . THR C 3 78  ? 147.851 239.768 343.281 1.00 104.90 ? 78  THR C O   1 
ATOM 3884 C CB  . THR C 3 78  ? 147.513 238.596 345.692 1.00 108.34 ? 78  THR C CB  1 
ATOM 3885 O OG1 . THR C 3 78  ? 148.847 238.989 346.035 1.00 107.65 ? 78  THR C OG1 1 
ATOM 3886 C CG2 . THR C 3 78  ? 146.882 237.861 346.863 1.00 105.64 ? 78  THR C CG2 1 
ATOM 3887 N N   . ASP C 3 79  ? 147.920 237.874 342.055 1.00 97.92  ? 79  ASP C N   1 
ATOM 3888 C CA  . ASP C 3 79  ? 147.972 238.526 340.748 1.00 98.74  ? 79  ASP C CA  1 
ATOM 3889 C C   . ASP C 3 79  ? 148.781 239.817 340.751 1.00 100.09 ? 79  ASP C C   1 
ATOM 3890 O O   . ASP C 3 79  ? 148.422 240.778 340.062 1.00 97.91  ? 79  ASP C O   1 
ATOM 3891 C CB  . ASP C 3 79  ? 146.555 238.813 340.243 1.00 100.05 ? 79  ASP C CB  1 
ATOM 3892 C CG  . ASP C 3 79  ? 145.769 239.709 341.180 1.00 103.16 ? 79  ASP C CG  1 
ATOM 3893 O OD1 . ASP C 3 79  ? 146.207 240.852 341.425 1.00 102.02 ? 79  ASP C OD1 1 
ATOM 3894 O OD2 . ASP C 3 79  ? 144.708 239.269 341.671 1.00 102.11 ? 79  ASP C OD2 1 
ATOM 3895 N N   . ASP C 3 80  ? 149.871 239.853 341.512 1.00 95.43  ? 80  ASP C N   1 
ATOM 3896 C CA  . ASP C 3 80  ? 150.777 240.985 341.497 1.00 92.06  ? 80  ASP C CA  1 
ATOM 3897 C C   . ASP C 3 80  ? 152.188 240.507 341.189 1.00 88.13  ? 80  ASP C C   1 
ATOM 3898 O O   . ASP C 3 80  ? 152.523 239.352 341.474 1.00 93.35  ? 80  ASP C O   1 
ATOM 3899 C CB  . ASP C 3 80  ? 150.765 241.733 342.838 1.00 91.80  ? 80  ASP C CB  1 
ATOM 3900 C CG  . ASP C 3 80  ? 150.956 240.811 344.020 1.00 96.51  ? 80  ASP C CG  1 
ATOM 3901 O OD1 . ASP C 3 80  ? 150.548 239.635 343.929 1.00 98.23  ? 80  ASP C OD1 1 
ATOM 3902 O OD2 . ASP C 3 80  ? 151.511 241.264 345.043 1.00 97.12  ? 80  ASP C OD2 1 
ATOM 3903 N N   . PRO C 3 81  ? 153.034 241.360 340.619 1.00 69.49  ? 81  PRO C N   1 
ATOM 3904 C CA  . PRO C 3 81  ? 154.318 240.879 340.100 1.00 69.27  ? 81  PRO C CA  1 
ATOM 3905 C C   . PRO C 3 81  ? 155.135 240.191 341.183 1.00 70.47  ? 81  PRO C C   1 
ATOM 3906 O O   . PRO C 3 81  ? 155.157 240.620 342.337 1.00 70.88  ? 81  PRO C O   1 
ATOM 3907 C CB  . PRO C 3 81  ? 155.007 242.156 339.607 1.00 73.98  ? 81  PRO C CB  1 
ATOM 3908 C CG  . PRO C 3 81  ? 153.953 243.196 339.545 1.00 72.89  ? 81  PRO C CG  1 
ATOM 3909 C CD  . PRO C 3 81  ? 152.913 242.823 340.538 1.00 74.99  ? 81  PRO C CD  1 
ATOM 3910 N N   . ILE C 3 82  ? 155.807 239.105 340.801 1.00 66.41  ? 82  ILE C N   1 
ATOM 3911 C CA  . ILE C 3 82  ? 156.811 238.528 341.687 1.00 66.55  ? 82  ILE C CA  1 
ATOM 3912 C C   . ILE C 3 82  ? 157.928 239.532 341.904 1.00 67.57  ? 82  ILE C C   1 
ATOM 3913 O O   . ILE C 3 82  ? 158.395 239.739 343.030 1.00 68.24  ? 82  ILE C O   1 
ATOM 3914 C CB  . ILE C 3 82  ? 157.362 237.210 341.115 1.00 61.53  ? 82  ILE C CB  1 
ATOM 3915 C CG1 . ILE C 3 82  ? 156.245 236.324 340.572 1.00 66.60  ? 82  ILE C CG1 1 
ATOM 3916 C CG2 . ILE C 3 82  ? 158.126 236.454 342.185 1.00 64.05  ? 82  ILE C CG2 1 
ATOM 3917 C CD1 . ILE C 3 82  ? 156.740 234.986 340.085 1.00 66.62  ? 82  ILE C CD1 1 
ATOM 3918 N N   . LEU C 3 83  ? 158.369 240.171 340.826 1.00 65.81  ? 83  LEU C N   1 
ATOM 3919 C CA  . LEU C 3 83  ? 159.415 241.177 340.876 1.00 63.46  ? 83  LEU C CA  1 
ATOM 3920 C C   . LEU C 3 83  ? 159.216 242.114 339.699 1.00 68.87  ? 83  LEU C C   1 
ATOM 3921 O O   . LEU C 3 83  ? 159.017 241.656 338.568 1.00 74.10  ? 83  LEU C O   1 
ATOM 3922 C CB  . LEU C 3 83  ? 160.801 240.532 340.819 1.00 55.34  ? 83  LEU C CB  1 
ATOM 3923 C CG  . LEU C 3 83  ? 161.061 239.709 339.559 1.00 57.54  ? 83  LEU C CG  1 
ATOM 3924 C CD1 . LEU C 3 83  ? 161.853 240.504 338.540 1.00 59.36  ? 83  LEU C CD1 1 
ATOM 3925 C CD2 . LEU C 3 83  ? 161.779 238.422 339.912 1.00 64.96  ? 83  LEU C CD2 1 
ATOM 3926 N N   . CYS C 3 84  ? 159.245 243.415 339.974 1.00 76.51  ? 84  CYS C N   1 
ATOM 3927 C CA  . CYS C 3 84  ? 159.232 244.451 338.952 1.00 76.97  ? 84  CYS C CA  1 
ATOM 3928 C C   . CYS C 3 84  ? 160.541 245.215 339.043 1.00 74.41  ? 84  CYS C C   1 
ATOM 3929 O O   . CYS C 3 84  ? 160.936 245.645 340.131 1.00 74.24  ? 84  CYS C O   1 
ATOM 3930 C CB  . CYS C 3 84  ? 158.044 245.398 339.132 1.00 78.54  ? 84  CYS C CB  1 
ATOM 3931 S SG  . CYS C 3 84  ? 157.999 246.238 340.733 1.00 92.37  ? 84  CYS C SG  1 
ATOM 3932 N N   . LEU C 3 85  ? 161.211 245.381 337.909 1.00 63.36  ? 85  LEU C N   1 
ATOM 3933 C CA  . LEU C 3 85  ? 162.564 245.909 337.872 1.00 63.11  ? 85  LEU C CA  1 
ATOM 3934 C C   . LEU C 3 85  ? 162.633 247.044 336.865 1.00 70.56  ? 85  LEU C C   1 
ATOM 3935 O O   . LEU C 3 85  ? 162.265 246.865 335.699 1.00 72.34  ? 85  LEU C O   1 
ATOM 3936 C CB  . LEU C 3 85  ? 163.550 244.797 337.507 1.00 63.49  ? 85  LEU C CB  1 
ATOM 3937 C CG  . LEU C 3 85  ? 165.036 245.128 337.489 1.00 67.99  ? 85  LEU C CG  1 
ATOM 3938 C CD1 . LEU C 3 85  ? 165.499 245.593 338.853 1.00 72.55  ? 85  LEU C CD1 1 
ATOM 3939 C CD2 . LEU C 3 85  ? 165.807 243.906 337.053 1.00 71.21  ? 85  LEU C CD2 1 
ATOM 3940 N N   . SER C 3 86  ? 163.096 248.205 337.317 1.00 71.88  ? 86  SER C N   1 
ATOM 3941 C CA  . SER C 3 86  ? 163.262 249.344 336.427 1.00 66.91  ? 86  SER C CA  1 
ATOM 3942 C C   . SER C 3 86  ? 164.432 249.112 335.483 1.00 63.41  ? 86  SER C C   1 
ATOM 3943 O O   . SER C 3 86  ? 165.465 248.563 335.871 1.00 67.24  ? 86  SER C O   1 
ATOM 3944 C CB  . SER C 3 86  ? 163.489 250.619 337.232 1.00 62.21  ? 86  SER C CB  1 
ATOM 3945 O OG  . SER C 3 86  ? 163.799 251.704 336.379 1.00 66.63  ? 86  SER C OG  1 
ATOM 3946 N N   . LEU C 3 87  ? 164.270 249.545 334.233 1.00 60.03  ? 87  LEU C N   1 
ATOM 3947 C CA  . LEU C 3 87  ? 165.294 249.374 333.212 1.00 59.23  ? 87  LEU C CA  1 
ATOM 3948 C C   . LEU C 3 87  ? 166.194 250.593 333.078 1.00 65.35  ? 87  LEU C C   1 
ATOM 3949 O O   . LEU C 3 87  ? 166.692 250.876 331.981 1.00 71.88  ? 87  LEU C O   1 
ATOM 3950 C CB  . LEU C 3 87  ? 164.642 249.045 331.870 1.00 61.29  ? 87  LEU C CB  1 
ATOM 3951 C CG  . LEU C 3 87  ? 163.885 247.720 331.840 1.00 66.92  ? 87  LEU C CG  1 
ATOM 3952 C CD1 . LEU C 3 87  ? 163.081 247.591 330.562 1.00 70.93  ? 87  LEU C CD1 1 
ATOM 3953 C CD2 . LEU C 3 87  ? 164.849 246.560 331.988 1.00 69.53  ? 87  LEU C CD2 1 
ATOM 3954 N N   . SER C 3 88  ? 166.411 251.325 334.163 1.00 73.39  ? 88  SER C N   1 
ATOM 3955 C CA  . SER C 3 88  ? 167.332 252.451 334.166 1.00 79.03  ? 88  SER C CA  1 
ATOM 3956 C C   . SER C 3 88  ? 168.567 252.087 334.980 1.00 75.08  ? 88  SER C C   1 
ATOM 3957 O O   . SER C 3 88  ? 168.645 252.416 336.171 1.00 72.45  ? 88  SER C O   1 
ATOM 3958 C CB  . SER C 3 88  ? 166.658 253.699 334.736 1.00 74.63  ? 88  SER C CB  1 
ATOM 3959 O OG  . SER C 3 88  ? 165.568 254.101 333.926 1.00 72.50  ? 88  SER C OG  1 
ATOM 3960 N N   . PRO C 3 89  ? 169.548 251.409 334.386 1.00 66.06  ? 89  PRO C N   1 
ATOM 3961 C CA  . PRO C 3 89  ? 170.748 251.052 335.145 1.00 69.32  ? 89  PRO C CA  1 
ATOM 3962 C C   . PRO C 3 89  ? 171.513 252.293 335.576 1.00 73.97  ? 89  PRO C C   1 
ATOM 3963 O O   . PRO C 3 89  ? 171.450 253.343 334.934 1.00 70.09  ? 89  PRO C O   1 
ATOM 3964 C CB  . PRO C 3 89  ? 171.557 250.205 334.156 1.00 67.26  ? 89  PRO C CB  1 
ATOM 3965 C CG  . PRO C 3 89  ? 171.086 250.634 332.823 1.00 67.94  ? 89  PRO C CG  1 
ATOM 3966 C CD  . PRO C 3 89  ? 169.636 250.970 332.984 1.00 62.64  ? 89  PRO C CD  1 
ATOM 3967 N N   . ALA C 3 90  ? 172.232 252.162 336.686 1.00 75.90  ? 90  ALA C N   1 
ATOM 3968 C CA  . ALA C 3 90  ? 173.025 253.209 337.316 1.00 74.39  ? 90  ALA C CA  1 
ATOM 3969 C C   . ALA C 3 90  ? 172.146 254.176 338.096 1.00 78.73  ? 90  ALA C C   1 
ATOM 3970 O O   . ALA C 3 90  ? 172.671 255.143 338.658 1.00 80.09  ? 90  ALA C O   1 
ATOM 3971 C CB  . ALA C 3 90  ? 173.866 254.008 336.309 1.00 69.85  ? 90  ALA C CB  1 
ATOM 3972 N N   . SER C 3 91  ? 170.833 253.959 338.146 1.00 77.93  ? 91  SER C N   1 
ATOM 3973 C CA  . SER C 3 91  ? 169.944 254.805 338.932 1.00 74.43  ? 91  SER C CA  1 
ATOM 3974 C C   . SER C 3 91  ? 169.064 253.951 339.834 1.00 76.03  ? 91  SER C C   1 
ATOM 3975 O O   . SER C 3 91  ? 168.673 254.386 340.921 1.00 80.71  ? 91  SER C O   1 
ATOM 3976 C CB  . SER C 3 91  ? 169.081 255.670 338.015 1.00 73.66  ? 91  SER C CB  1 
ATOM 3977 O OG  . SER C 3 91  ? 168.299 254.867 337.150 1.00 73.81  ? 91  SER C OG  1 
ATOM 3978 N N   . ASP C 3 92  ? 168.748 252.740 339.393 1.00 75.92  ? 92  ASP C N   1 
ATOM 3979 C CA  . ASP C 3 92  ? 167.908 251.846 340.178 1.00 78.26  ? 92  ASP C CA  1 
ATOM 3980 C C   . ASP C 3 92  ? 168.719 251.260 341.328 1.00 79.29  ? 92  ASP C C   1 
ATOM 3981 O O   . ASP C 3 92  ? 169.756 250.634 341.080 1.00 83.12  ? 92  ASP C O   1 
ATOM 3982 C CB  . ASP C 3 92  ? 167.358 250.732 339.299 1.00 74.63  ? 92  ASP C CB  1 
ATOM 3983 C CG  . ASP C 3 92  ? 166.264 249.939 339.979 1.00 79.68  ? 92  ASP C CG  1 
ATOM 3984 O OD1 . ASP C 3 92  ? 165.993 250.195 341.169 1.00 83.87  ? 92  ASP C OD1 1 
ATOM 3985 O OD2 . ASP C 3 92  ? 165.670 249.061 339.321 1.00 80.13  ? 92  ASP C OD2 1 
ATOM 3986 N N   . PRO C 3 93  ? 168.297 251.429 342.584 1.00 74.05  ? 93  PRO C N   1 
ATOM 3987 C CA  . PRO C 3 93  ? 169.116 250.906 343.690 1.00 75.31  ? 93  PRO C CA  1 
ATOM 3988 C C   . PRO C 3 93  ? 169.403 249.419 343.583 1.00 77.18  ? 93  PRO C C   1 
ATOM 3989 O O   . PRO C 3 93  ? 170.501 248.978 343.942 1.00 78.19  ? 93  PRO C O   1 
ATOM 3990 C CB  . PRO C 3 93  ? 168.274 251.236 344.929 1.00 72.53  ? 93  PRO C CB  1 
ATOM 3991 C CG  . PRO C 3 93  ? 167.466 252.405 344.528 1.00 73.01  ? 93  PRO C CG  1 
ATOM 3992 C CD  . PRO C 3 93  ? 167.149 252.209 343.078 1.00 73.27  ? 93  PRO C CD  1 
ATOM 3993 N N   . ARG C 3 94  ? 168.450 248.632 343.097 1.00 70.67  ? 94  ARG C N   1 
ATOM 3994 C CA  . ARG C 3 94  ? 168.604 247.188 343.007 1.00 70.99  ? 94  ARG C CA  1 
ATOM 3995 C C   . ARG C 3 94  ? 169.286 246.750 341.721 1.00 65.75  ? 94  ARG C C   1 
ATOM 3996 O O   . ARG C 3 94  ? 169.409 245.547 341.478 1.00 71.01  ? 94  ARG C O   1 
ATOM 3997 C CB  . ARG C 3 94  ? 167.239 246.507 343.124 1.00 74.39  ? 94  ARG C CB  1 
ATOM 3998 C CG  . ARG C 3 94  ? 166.478 246.888 344.379 1.00 76.99  ? 94  ARG C CG  1 
ATOM 3999 C CD  . ARG C 3 94  ? 165.180 246.114 344.516 1.00 70.55  ? 94  ARG C CD  1 
ATOM 4000 N NE  . ARG C 3 94  ? 164.265 246.362 343.409 1.00 65.51  ? 94  ARG C NE  1 
ATOM 4001 C CZ  . ARG C 3 94  ? 164.206 245.634 342.303 1.00 67.61  ? 94  ARG C CZ  1 
ATOM 4002 N NH1 . ARG C 3 94  ? 165.009 244.602 342.110 1.00 68.43  ? 94  ARG C NH1 1 
ATOM 4003 N NH2 . ARG C 3 94  ? 163.318 245.950 341.366 1.00 74.53  ? 94  ARG C NH2 1 
ATOM 4004 N N   . LEU C 3 95  ? 169.722 247.695 340.889 1.00 55.97  ? 95  LEU C N   1 
ATOM 4005 C CA  . LEU C 3 95  ? 170.379 247.373 339.631 1.00 60.61  ? 95  LEU C CA  1 
ATOM 4006 C C   . LEU C 3 95  ? 171.648 248.189 339.426 1.00 61.93  ? 95  LEU C C   1 
ATOM 4007 O O   . LEU C 3 95  ? 172.245 248.121 338.346 1.00 64.03  ? 95  LEU C O   1 
ATOM 4008 C CB  . LEU C 3 95  ? 169.418 247.598 338.458 1.00 60.54  ? 95  LEU C CB  1 
ATOM 4009 C CG  . LEU C 3 95  ? 169.750 246.933 337.123 1.00 61.15  ? 95  LEU C CG  1 
ATOM 4010 C CD1 . LEU C 3 95  ? 169.826 245.432 337.274 1.00 64.89  ? 95  LEU C CD1 1 
ATOM 4011 C CD2 . LEU C 3 95  ? 168.708 247.301 336.089 1.00 63.87  ? 95  LEU C CD2 1 
ATOM 4012 N N   . SER C 3 96  ? 172.077 248.953 340.430 1.00 62.54  ? 96  SER C N   1 
ATOM 4013 C CA  . SER C 3 96  ? 173.251 249.809 340.328 1.00 62.60  ? 96  SER C CA  1 
ATOM 4014 C C   . SER C 3 96  ? 174.454 249.229 341.061 1.00 69.78  ? 96  SER C C   1 
ATOM 4015 O O   . SER C 3 96  ? 175.291 249.979 341.572 1.00 71.44  ? 96  SER C O   1 
ATOM 4016 C CB  . SER C 3 96  ? 172.933 251.205 340.860 1.00 63.83  ? 96  SER C CB  1 
ATOM 4017 O OG  . SER C 3 96  ? 172.573 251.157 342.228 1.00 66.59  ? 96  SER C OG  1 
ATOM 4018 N N   . HIS C 3 97  ? 174.550 247.901 341.135 1.00 66.86  ? 97  HIS C N   1 
ATOM 4019 C CA  . HIS C 3 97  ? 175.712 247.251 341.727 1.00 60.31  ? 97  HIS C CA  1 
ATOM 4020 C C   . HIS C 3 97  ? 176.168 246.045 340.919 1.00 58.36  ? 97  HIS C C   1 
ATOM 4021 O O   . HIS C 3 97  ? 177.002 245.276 341.407 1.00 61.36  ? 97  HIS C O   1 
ATOM 4022 C CB  . HIS C 3 97  ? 175.417 246.801 343.159 1.00 61.93  ? 97  HIS C CB  1 
ATOM 4023 C CG  . HIS C 3 97  ? 174.974 247.905 344.064 1.00 66.17  ? 97  HIS C CG  1 
ATOM 4024 N ND1 . HIS C 3 97  ? 175.843 248.849 344.567 1.00 63.93  ? 97  HIS C ND1 1 
ATOM 4025 C CD2 . HIS C 3 97  ? 173.755 248.208 344.569 1.00 62.37  ? 97  HIS C CD2 1 
ATOM 4026 C CE1 . HIS C 3 97  ? 175.177 249.690 345.337 1.00 65.61  ? 97  HIS C CE1 1 
ATOM 4027 N NE2 . HIS C 3 97  ? 173.908 249.324 345.355 1.00 68.23  ? 97  HIS C NE2 1 
ATOM 4028 N N   . THR C 3 98  ? 175.656 245.860 339.703 1.00 59.97  ? 98  THR C N   1 
ATOM 4029 C CA  . THR C 3 98  ? 175.795 244.610 338.970 1.00 64.62  ? 98  THR C CA  1 
ATOM 4030 C C   . THR C 3 98  ? 176.881 244.673 337.905 1.00 69.02  ? 98  THR C C   1 
ATOM 4031 O O   . THR C 3 98  ? 176.799 243.965 336.897 1.00 73.71  ? 98  THR C O   1 
ATOM 4032 C CB  . THR C 3 98  ? 174.459 244.238 338.332 1.00 53.51  ? 98  THR C CB  1 
ATOM 4033 O OG1 . THR C 3 98  ? 174.193 245.122 337.240 1.00 56.39  ? 98  THR C OG1 1 
ATOM 4034 C CG2 . THR C 3 98  ? 173.341 244.356 339.346 1.00 56.09  ? 98  THR C CG2 1 
ATOM 4035 N N   . MET C 3 99  ? 177.886 245.523 338.096 1.00 60.07  ? 99  MET C N   1 
ATOM 4036 C CA  . MET C 3 99  ? 178.969 245.679 337.130 1.00 61.53  ? 99  MET C CA  1 
ATOM 4037 C C   . MET C 3 99  ? 178.492 246.443 335.902 1.00 68.68  ? 99  MET C C   1 
ATOM 4038 O O   . MET C 3 99  ? 179.286 246.740 335.006 1.00 74.37  ? 99  MET C O   1 
ATOM 4039 C CB  . MET C 3 99  ? 179.532 244.320 336.717 1.00 58.85  ? 99  MET C CB  1 
ATOM 4040 C CG  . MET C 3 99  ? 180.941 244.378 336.154 1.00 64.26  ? 99  MET C CG  1 
ATOM 4041 S SD  . MET C 3 99  ? 182.171 244.705 337.427 1.00 77.05  ? 99  MET C SD  1 
ATOM 4042 C CE  . MET C 3 99  ? 183.678 244.649 336.465 1.00 63.90  ? 99  MET C CE  1 
ATOM 4043 N N   . LEU C 3 100 ? 177.198 246.748 335.838 1.00 61.17  ? 100 LEU C N   1 
ATOM 4044 C CA  . LEU C 3 100 ? 176.697 247.805 334.975 1.00 56.22  ? 100 LEU C CA  1 
ATOM 4045 C C   . LEU C 3 100 ? 176.453 249.090 335.740 1.00 65.78  ? 100 LEU C C   1 
ATOM 4046 O O   . LEU C 3 100 ? 176.623 250.174 335.180 1.00 74.67  ? 100 LEU C O   1 
ATOM 4047 C CB  . LEU C 3 100 ? 175.400 247.378 334.284 1.00 53.55  ? 100 LEU C CB  1 
ATOM 4048 C CG  . LEU C 3 100 ? 175.586 246.909 332.843 1.00 53.81  ? 100 LEU C CG  1 
ATOM 4049 C CD1 . LEU C 3 100 ? 176.370 245.616 332.807 1.00 63.27  ? 100 LEU C CD1 1 
ATOM 4050 C CD2 . LEU C 3 100 ? 174.246 246.751 332.154 1.00 59.40  ? 100 LEU C CD2 1 
ATOM 4051 N N   . GLY C 3 101 ? 176.061 248.990 337.006 1.00 63.72  ? 101 GLY C N   1 
ATOM 4052 C CA  . GLY C 3 101 ? 176.047 250.147 337.871 1.00 63.62  ? 101 GLY C CA  1 
ATOM 4053 C C   . GLY C 3 101 ? 177.403 250.543 338.397 1.00 61.78  ? 101 GLY C C   1 
ATOM 4054 O O   . GLY C 3 101 ? 177.532 251.612 338.998 1.00 67.66  ? 101 GLY C O   1 
ATOM 4055 N N   . GLU C 3 102 ? 178.416 249.701 338.195 1.00 56.94  ? 102 GLU C N   1 
ATOM 4056 C CA  . GLU C 3 102 ? 179.778 250.013 338.598 1.00 58.42  ? 102 GLU C CA  1 
ATOM 4057 C C   . GLU C 3 102 ? 180.612 250.578 337.461 1.00 55.85  ? 102 GLU C C   1 
ATOM 4058 O O   . GLU C 3 102 ? 181.683 251.134 337.720 1.00 55.83  ? 102 GLU C O   1 
ATOM 4059 C CB  . GLU C 3 102 ? 180.472 248.763 339.152 1.00 64.14  ? 102 GLU C CB  1 
ATOM 4060 C CG  . GLU C 3 102 ? 179.790 248.137 340.358 1.00 71.53  ? 102 GLU C CG  1 
ATOM 4061 C CD  . GLU C 3 102 ? 179.903 248.986 341.608 1.00 66.21  ? 102 GLU C CD  1 
ATOM 4062 O OE1 . GLU C 3 102 ? 179.554 250.182 341.556 1.00 68.38  ? 102 GLU C OE1 1 
ATOM 4063 O OE2 . GLU C 3 102 ? 180.344 248.455 342.648 1.00 62.40  ? 102 GLU C OE2 1 
ATOM 4064 N N   . ILE C 3 103 ? 180.156 250.444 336.219 1.00 56.94  ? 103 ILE C N   1 
ATOM 4065 C CA  . ILE C 3 103 ? 180.844 251.028 335.076 1.00 60.13  ? 103 ILE C CA  1 
ATOM 4066 C C   . ILE C 3 103 ? 180.096 252.277 334.638 1.00 58.54  ? 103 ILE C C   1 
ATOM 4067 O O   . ILE C 3 103 ? 180.702 253.234 334.145 1.00 65.57  ? 103 ILE C O   1 
ATOM 4068 C CB  . ILE C 3 103 ? 180.966 250.021 333.921 1.00 54.23  ? 103 ILE C CB  1 
ATOM 4069 C CG1 . ILE C 3 103 ? 181.931 248.904 334.314 1.00 56.53  ? 103 ILE C CG1 1 
ATOM 4070 C CG2 . ILE C 3 103 ? 181.435 250.724 332.660 1.00 55.25  ? 103 ILE C CG2 1 
ATOM 4071 C CD1 . ILE C 3 103 ? 181.973 247.765 333.337 1.00 65.69  ? 103 ILE C CD1 1 
ATOM 4072 N N   . LEU C 3 104 ? 178.779 252.281 334.815 1.00 49.95  ? 104 LEU C N   1 
ATOM 4073 C CA  . LEU C 3 104 ? 177.976 253.455 334.512 1.00 51.38  ? 104 LEU C CA  1 
ATOM 4074 C C   . LEU C 3 104 ? 177.953 254.455 335.657 1.00 52.69  ? 104 LEU C C   1 
ATOM 4075 O O   . LEU C 3 104 ? 177.358 255.526 335.510 1.00 64.97  ? 104 LEU C O   1 
ATOM 4076 C CB  . LEU C 3 104 ? 176.545 253.049 334.157 1.00 52.35  ? 104 LEU C CB  1 
ATOM 4077 C CG  . LEU C 3 104 ? 176.318 252.508 332.744 1.00 52.05  ? 104 LEU C CG  1 
ATOM 4078 C CD1 . LEU C 3 104 ? 177.359 251.478 332.361 1.00 58.80  ? 104 LEU C CD1 1 
ATOM 4079 C CD2 . LEU C 3 104 ? 174.927 251.917 332.633 1.00 52.81  ? 104 LEU C CD2 1 
ATOM 4080 N N   . ASN C 3 105 ? 178.570 254.136 336.789 1.00 47.79  ? 105 ASN C N   1 
ATOM 4081 C CA  . ASN C 3 105 ? 178.807 255.122 337.830 1.00 53.25  ? 105 ASN C CA  1 
ATOM 4082 C C   . ASN C 3 105 ? 180.129 255.849 337.639 1.00 59.98  ? 105 ASN C C   1 
ATOM 4083 O O   . ASN C 3 105 ? 180.469 256.713 338.452 1.00 56.94  ? 105 ASN C O   1 
ATOM 4084 C CB  . ASN C 3 105 ? 178.767 254.461 339.208 1.00 54.19  ? 105 ASN C CB  1 
ATOM 4085 C CG  . ASN C 3 105 ? 177.364 254.394 339.775 1.00 69.30  ? 105 ASN C CG  1 
ATOM 4086 O OD1 . ASN C 3 105 ? 177.020 255.128 340.701 1.00 64.53  ? 105 ASN C OD1 1 
ATOM 4087 N ND2 . ASN C 3 105 ? 176.540 253.522 339.212 1.00 73.61  ? 105 ASN C ND2 1 
ATOM 4088 N N   . TYR C 3 106 ? 180.881 255.508 336.591 1.00 56.86  ? 106 TYR C N   1 
ATOM 4089 C CA  . TYR C 3 106 ? 182.040 256.277 336.170 1.00 53.32  ? 106 TYR C CA  1 
ATOM 4090 C C   . TYR C 3 106 ? 181.785 257.112 334.929 1.00 48.39  ? 106 TYR C C   1 
ATOM 4091 O O   . TYR C 3 106 ? 182.611 257.969 334.606 1.00 58.25  ? 106 TYR C O   1 
ATOM 4092 C CB  . TYR C 3 106 ? 183.232 255.350 335.891 1.00 47.08  ? 106 TYR C CB  1 
ATOM 4093 C CG  . TYR C 3 106 ? 183.936 254.842 337.127 1.00 42.89  ? 106 TYR C CG  1 
ATOM 4094 C CD1 . TYR C 3 106 ? 184.160 255.669 338.215 1.00 51.15  ? 106 TYR C CD1 1 
ATOM 4095 C CD2 . TYR C 3 106 ? 184.377 253.533 337.204 1.00 39.67  ? 106 TYR C CD2 1 
ATOM 4096 C CE1 . TYR C 3 106 ? 184.798 255.208 339.339 1.00 50.08  ? 106 TYR C CE1 1 
ATOM 4097 C CE2 . TYR C 3 106 ? 185.015 253.064 338.325 1.00 47.10  ? 106 TYR C CE2 1 
ATOM 4098 C CZ  . TYR C 3 106 ? 185.224 253.907 339.389 1.00 51.24  ? 106 TYR C CZ  1 
ATOM 4099 O OH  . TYR C 3 106 ? 185.862 253.446 340.513 1.00 60.96  ? 106 TYR C OH  1 
ATOM 4100 N N   . TYR C 3 107 ? 180.678 256.886 334.233 1.00 43.58  ? 107 TYR C N   1 
ATOM 4101 C CA  . TYR C 3 107 ? 180.341 257.603 333.015 1.00 48.70  ? 107 TYR C CA  1 
ATOM 4102 C C   . TYR C 3 107 ? 179.066 258.409 333.215 1.00 48.33  ? 107 TYR C C   1 
ATOM 4103 O O   . TYR C 3 107 ? 178.389 258.307 334.240 1.00 50.18  ? 107 TYR C O   1 
ATOM 4104 C CB  . TYR C 3 107 ? 180.189 256.627 331.848 1.00 38.77  ? 107 TYR C CB  1 
ATOM 4105 C CG  . TYR C 3 107 ? 181.510 256.073 331.392 1.00 38.19  ? 107 TYR C CG  1 
ATOM 4106 C CD1 . TYR C 3 107 ? 182.213 255.177 332.177 1.00 38.28  ? 107 TYR C CD1 1 
ATOM 4107 C CD2 . TYR C 3 107 ? 182.060 256.455 330.183 1.00 52.78  ? 107 TYR C CD2 1 
ATOM 4108 C CE1 . TYR C 3 107 ? 183.423 254.673 331.765 1.00 40.77  ? 107 TYR C CE1 1 
ATOM 4109 C CE2 . TYR C 3 107 ? 183.269 255.957 329.765 1.00 53.54  ? 107 TYR C CE2 1 
ATOM 4110 C CZ  . TYR C 3 107 ? 183.944 255.067 330.558 1.00 43.31  ? 107 TYR C CZ  1 
ATOM 4111 O OH  . TYR C 3 107 ? 185.150 254.573 330.140 1.00 41.02  ? 107 TYR C OH  1 
ATOM 4112 N N   . THR C 3 108 ? 178.750 259.222 332.215 1.00 49.47  ? 108 THR C N   1 
ATOM 4113 C CA  . THR C 3 108 ? 177.604 260.118 332.267 1.00 50.35  ? 108 THR C CA  1 
ATOM 4114 C C   . THR C 3 108 ? 176.517 259.758 331.272 1.00 53.17  ? 108 THR C C   1 
ATOM 4115 O O   . THR C 3 108 ? 175.334 259.904 331.583 1.00 60.88  ? 108 THR C O   1 
ATOM 4116 C CB  . THR C 3 108 ? 178.051 261.558 332.012 1.00 50.30  ? 108 THR C CB  1 
ATOM 4117 O OG1 . THR C 3 108 ? 179.169 261.870 332.849 1.00 53.04  ? 108 THR C OG1 1 
ATOM 4118 C CG2 . THR C 3 108 ? 176.922 262.523 332.311 1.00 54.56  ? 108 THR C CG2 1 
ATOM 4119 N N   . HIS C 3 109 ? 176.883 259.294 330.082 1.00 49.69  ? 109 HIS C N   1 
ATOM 4120 C CA  . HIS C 3 109 ? 175.931 258.925 329.049 1.00 44.50  ? 109 HIS C CA  1 
ATOM 4121 C C   . HIS C 3 109 ? 176.086 257.449 328.724 1.00 50.97  ? 109 HIS C C   1 
ATOM 4122 O O   . HIS C 3 109 ? 177.205 256.937 328.651 1.00 66.71  ? 109 HIS C O   1 
ATOM 4123 C CB  . HIS C 3 109 ? 176.144 259.746 327.780 1.00 49.29  ? 109 HIS C CB  1 
ATOM 4124 C CG  . HIS C 3 109 ? 176.117 261.225 327.999 1.00 54.97  ? 109 HIS C CG  1 
ATOM 4125 N ND1 . HIS C 3 109 ? 176.534 262.123 327.042 1.00 45.44  ? 109 HIS C ND1 1 
ATOM 4126 C CD2 . HIS C 3 109 ? 175.720 261.965 329.060 1.00 60.61  ? 109 HIS C CD2 1 
ATOM 4127 C CE1 . HIS C 3 109 ? 176.399 263.352 327.504 1.00 48.97  ? 109 HIS C CE1 1 
ATOM 4128 N NE2 . HIS C 3 109 ? 175.907 263.284 328.727 1.00 55.85  ? 109 HIS C NE2 1 
ATOM 4129 N N   . TRP C 3 110 ? 174.960 256.766 328.533 1.00 46.44  ? 110 TRP C N   1 
ATOM 4130 C CA  . TRP C 3 110 ? 174.960 255.365 328.142 1.00 46.42  ? 110 TRP C CA  1 
ATOM 4131 C C   . TRP C 3 110 ? 173.908 255.153 327.070 1.00 48.41  ? 110 TRP C C   1 
ATOM 4132 O O   . TRP C 3 110 ? 172.869 255.816 327.063 1.00 69.76  ? 110 TRP C O   1 
ATOM 4133 C CB  . TRP C 3 110 ? 174.681 254.445 329.329 1.00 52.25  ? 110 TRP C CB  1 
ATOM 4134 C CG  . TRP C 3 110 ? 173.247 254.393 329.729 1.00 50.77  ? 110 TRP C CG  1 
ATOM 4135 C CD1 . TRP C 3 110 ? 172.611 255.217 330.604 1.00 53.20  ? 110 TRP C CD1 1 
ATOM 4136 C CD2 . TRP C 3 110 ? 172.267 253.456 329.277 1.00 53.26  ? 110 TRP C CD2 1 
ATOM 4137 N NE1 . TRP C 3 110 ? 171.293 254.855 330.725 1.00 54.96  ? 110 TRP C NE1 1 
ATOM 4138 C CE2 . TRP C 3 110 ? 171.057 253.775 329.917 1.00 53.56  ? 110 TRP C CE2 1 
ATOM 4139 C CE3 . TRP C 3 110 ? 172.295 252.379 328.389 1.00 57.26  ? 110 TRP C CE3 1 
ATOM 4140 C CZ2 . TRP C 3 110 ? 169.889 253.058 329.700 1.00 55.91  ? 110 TRP C CZ2 1 
ATOM 4141 C CZ3 . TRP C 3 110 ? 171.135 251.669 328.174 1.00 58.69  ? 110 TRP C CZ3 1 
ATOM 4142 C CH2 . TRP C 3 110 ? 169.948 252.010 328.826 1.00 52.26  ? 110 TRP C CH2 1 
ATOM 4143 N N   . ALA C 3 111 ? 174.178 254.218 326.161 1.00 38.08  ? 111 ALA C N   1 
ATOM 4144 C CA  . ALA C 3 111 ? 173.252 253.953 325.061 1.00 42.25  ? 111 ALA C CA  1 
ATOM 4145 C C   . ALA C 3 111 ? 173.466 252.516 324.601 1.00 52.09  ? 111 ALA C C   1 
ATOM 4146 O O   . ALA C 3 111 ? 174.428 252.233 323.886 1.00 62.81  ? 111 ALA C O   1 
ATOM 4147 C CB  . ALA C 3 111 ? 173.469 254.932 323.921 1.00 53.37  ? 111 ALA C CB  1 
ATOM 4148 N N   . GLY C 3 112 ? 172.558 251.629 324.987 1.00 57.41  ? 112 GLY C N   1 
ATOM 4149 C CA  . GLY C 3 112 ? 172.655 250.255 324.538 1.00 56.62  ? 112 GLY C CA  1 
ATOM 4150 C C   . GLY C 3 112 ? 171.427 249.471 324.935 1.00 54.56  ? 112 GLY C C   1 
ATOM 4151 O O   . GLY C 3 112 ? 170.477 250.004 325.514 1.00 55.31  ? 112 GLY C O   1 
ATOM 4152 N N   . SER C 3 113 ? 171.464 248.184 324.610 1.00 56.98  ? 113 SER C N   1 
ATOM 4153 C CA  . SER C 3 113 ? 170.407 247.244 324.945 1.00 58.68  ? 113 SER C CA  1 
ATOM 4154 C C   . SER C 3 113 ? 170.907 246.309 326.034 1.00 51.93  ? 113 SER C C   1 
ATOM 4155 O O   . SER C 3 113 ? 172.015 245.775 325.935 1.00 55.96  ? 113 SER C O   1 
ATOM 4156 C CB  . SER C 3 113 ? 169.979 246.448 323.713 1.00 61.23  ? 113 SER C CB  1 
ATOM 4157 O OG  . SER C 3 113 ? 171.104 245.890 323.059 1.00 60.87  ? 113 SER C OG  1 
ATOM 4158 N N   . LEU C 3 114 ? 170.100 246.124 327.072 1.00 50.71  ? 114 LEU C N   1 
ATOM 4159 C CA  . LEU C 3 114 ? 170.473 245.263 328.184 1.00 56.34  ? 114 LEU C CA  1 
ATOM 4160 C C   . LEU C 3 114 ? 170.100 243.819 327.859 1.00 55.13  ? 114 LEU C C   1 
ATOM 4161 O O   . LEU C 3 114 ? 169.687 243.492 326.745 1.00 64.35  ? 114 LEU C O   1 
ATOM 4162 C CB  . LEU C 3 114 ? 169.807 245.742 329.468 1.00 55.23  ? 114 LEU C CB  1 
ATOM 4163 C CG  . LEU C 3 114 ? 170.015 247.216 329.799 1.00 55.76  ? 114 LEU C CG  1 
ATOM 4164 C CD1 . LEU C 3 114 ? 169.381 247.540 331.136 1.00 59.17  ? 114 LEU C CD1 1 
ATOM 4165 C CD2 . LEU C 3 114 ? 171.488 247.564 329.804 1.00 51.91  ? 114 LEU C CD2 1 
ATOM 4166 N N   . LYS C 3 115 ? 170.259 242.933 328.837 1.00 47.29  ? 115 LYS C N   1 
ATOM 4167 C CA  . LYS C 3 115 ? 169.919 241.525 328.662 1.00 45.95  ? 115 LYS C CA  1 
ATOM 4168 C C   . LYS C 3 115 ? 169.712 240.919 330.038 1.00 50.20  ? 115 LYS C C   1 
ATOM 4169 O O   . LYS C 3 115 ? 170.654 240.865 330.835 1.00 58.59  ? 115 LYS C O   1 
ATOM 4170 C CB  . LYS C 3 115 ? 171.022 240.793 327.904 1.00 51.29  ? 115 LYS C CB  1 
ATOM 4171 C CG  . LYS C 3 115 ? 170.781 239.308 327.728 1.00 57.41  ? 115 LYS C CG  1 
ATOM 4172 C CD  . LYS C 3 115 ? 171.944 238.630 327.025 1.00 58.02  ? 115 LYS C CD  1 
ATOM 4173 C CE  . LYS C 3 115 ? 172.081 239.101 325.588 1.00 58.18  ? 115 LYS C CE  1 
ATOM 4174 N NZ  . LYS C 3 115 ? 173.129 238.348 324.844 1.00 62.51  ? 115 LYS C NZ  1 
ATOM 4175 N N   . PHE C 3 116 ? 168.491 240.474 330.321 1.00 47.94  ? 116 PHE C N   1 
ATOM 4176 C CA  . PHE C 3 116 ? 168.133 239.898 331.610 1.00 46.92  ? 116 PHE C CA  1 
ATOM 4177 C C   . PHE C 3 116 ? 167.909 238.405 331.438 1.00 51.78  ? 116 PHE C C   1 
ATOM 4178 O O   . PHE C 3 116 ? 167.068 237.990 330.635 1.00 66.28  ? 116 PHE C O   1 
ATOM 4179 C CB  . PHE C 3 116 ? 166.873 240.550 332.174 1.00 49.44  ? 116 PHE C CB  1 
ATOM 4180 C CG  . PHE C 3 116 ? 167.046 241.990 332.534 1.00 58.20  ? 116 PHE C CG  1 
ATOM 4181 C CD1 . PHE C 3 116 ? 167.011 242.967 331.561 1.00 58.00  ? 116 PHE C CD1 1 
ATOM 4182 C CD2 . PHE C 3 116 ? 167.233 242.368 333.849 1.00 55.28  ? 116 PHE C CD2 1 
ATOM 4183 C CE1 . PHE C 3 116 ? 167.167 244.291 331.890 1.00 55.52  ? 116 PHE C CE1 1 
ATOM 4184 C CE2 . PHE C 3 116 ? 167.389 243.691 334.180 1.00 51.48  ? 116 PHE C CE2 1 
ATOM 4185 C CZ  . PHE C 3 116 ? 167.355 244.653 333.201 1.00 51.66  ? 116 PHE C CZ  1 
ATOM 4186 N N   . THR C 3 117 ? 168.646 237.607 332.197 1.00 58.44  ? 117 THR C N   1 
ATOM 4187 C CA  . THR C 3 117 ? 168.471 236.162 332.228 1.00 56.84  ? 117 THR C CA  1 
ATOM 4188 C C   . THR C 3 117 ? 167.949 235.776 333.602 1.00 54.92  ? 117 THR C C   1 
ATOM 4189 O O   . THR C 3 117 ? 168.588 236.070 334.616 1.00 60.69  ? 117 THR C O   1 
ATOM 4190 C CB  . THR C 3 117 ? 169.784 235.440 331.930 1.00 65.65  ? 117 THR C CB  1 
ATOM 4191 O OG1 . THR C 3 117 ? 170.248 235.802 330.624 1.00 73.32  ? 117 THR C OG1 1 
ATOM 4192 C CG2 . THR C 3 117 ? 169.594 233.937 331.997 1.00 61.93  ? 117 THR C CG2 1 
ATOM 4193 N N   . PHE C 3 118 ? 166.790 235.132 333.635 1.00 52.58  ? 118 PHE C N   1 
ATOM 4194 C CA  . PHE C 3 118 ? 166.206 234.639 334.872 1.00 55.17  ? 118 PHE C CA  1 
ATOM 4195 C C   . PHE C 3 118 ? 166.401 233.133 334.925 1.00 57.78  ? 118 PHE C C   1 
ATOM 4196 O O   . PHE C 3 118 ? 165.957 232.417 334.022 1.00 64.88  ? 118 PHE C O   1 
ATOM 4197 C CB  . PHE C 3 118 ? 164.724 234.991 334.962 1.00 56.67  ? 118 PHE C CB  1 
ATOM 4198 C CG  . PHE C 3 118 ? 164.463 236.446 335.179 1.00 54.52  ? 118 PHE C CG  1 
ATOM 4199 C CD1 . PHE C 3 118 ? 164.686 237.023 336.413 1.00 54.11  ? 118 PHE C CD1 1 
ATOM 4200 C CD2 . PHE C 3 118 ? 163.985 237.237 334.154 1.00 57.55  ? 118 PHE C CD2 1 
ATOM 4201 C CE1 . PHE C 3 118 ? 164.445 238.360 336.617 1.00 56.61  ? 118 PHE C CE1 1 
ATOM 4202 C CE2 . PHE C 3 118 ? 163.742 238.573 334.355 1.00 64.52  ? 118 PHE C CE2 1 
ATOM 4203 C CZ  . PHE C 3 118 ? 163.972 239.135 335.588 1.00 62.22  ? 118 PHE C CZ  1 
ATOM 4204 N N   . MET C 3 119 ? 167.063 232.663 335.975 1.00 53.86  ? 119 MET C N   1 
ATOM 4205 C CA  . MET C 3 119 ? 167.331 231.250 336.183 1.00 55.07  ? 119 MET C CA  1 
ATOM 4206 C C   . MET C 3 119 ? 166.471 230.749 337.333 1.00 60.77  ? 119 MET C C   1 
ATOM 4207 O O   . MET C 3 119 ? 166.268 231.457 338.322 1.00 64.58  ? 119 MET C O   1 
ATOM 4208 C CB  . MET C 3 119 ? 168.810 231.015 336.491 1.00 56.70  ? 119 MET C CB  1 
ATOM 4209 C CG  . MET C 3 119 ? 169.283 229.605 336.206 1.00 60.06  ? 119 MET C CG  1 
ATOM 4210 S SD  . MET C 3 119 ? 171.033 229.372 336.562 1.00 73.87  ? 119 MET C SD  1 
ATOM 4211 C CE  . MET C 3 119 ? 171.024 229.438 338.350 1.00 64.65  ? 119 MET C CE  1 
ATOM 4212 N N   . PHE C 3 120 ? 165.959 229.535 337.194 1.00 59.72  ? 120 PHE C N   1 
ATOM 4213 C CA  . PHE C 3 120 ? 165.019 228.959 338.148 1.00 55.89  ? 120 PHE C CA  1 
ATOM 4214 C C   . PHE C 3 120 ? 165.727 227.850 338.914 1.00 58.93  ? 120 PHE C C   1 
ATOM 4215 O O   . PHE C 3 120 ? 166.008 226.787 338.353 1.00 69.40  ? 120 PHE C O   1 
ATOM 4216 C CB  . PHE C 3 120 ? 163.789 228.434 337.416 1.00 53.97  ? 120 PHE C CB  1 
ATOM 4217 C CG  . PHE C 3 120 ? 162.778 227.799 338.310 1.00 54.78  ? 120 PHE C CG  1 
ATOM 4218 C CD1 . PHE C 3 120 ? 161.963 228.569 339.113 1.00 57.97  ? 120 PHE C CD1 1 
ATOM 4219 C CD2 . PHE C 3 120 ? 162.632 226.430 338.337 1.00 62.02  ? 120 PHE C CD2 1 
ATOM 4220 C CE1 . PHE C 3 120 ? 161.032 227.982 339.929 1.00 61.97  ? 120 PHE C CE1 1 
ATOM 4221 C CE2 . PHE C 3 120 ? 161.701 225.840 339.151 1.00 59.56  ? 120 PHE C CE2 1 
ATOM 4222 C CZ  . PHE C 3 120 ? 160.902 226.615 339.946 1.00 62.29  ? 120 PHE C CZ  1 
ATOM 4223 N N   . CYS C 3 121 ? 166.020 228.095 340.189 1.00 59.62  ? 121 CYS C N   1 
ATOM 4224 C CA  . CYS C 3 121 ? 166.738 227.129 341.013 1.00 56.69  ? 121 CYS C CA  1 
ATOM 4225 C C   . CYS C 3 121 ? 165.737 226.290 341.805 1.00 65.47  ? 121 CYS C C   1 
ATOM 4226 O O   . CYS C 3 121 ? 165.603 226.397 343.024 1.00 62.58  ? 121 CYS C O   1 
ATOM 4227 C CB  . CYS C 3 121 ? 167.719 227.847 341.930 1.00 63.88  ? 121 CYS C CB  1 
ATOM 4228 S SG  . CYS C 3 121 ? 168.978 228.793 341.055 1.00 85.22  ? 121 CYS C SG  1 
ATOM 4229 N N   . GLY C 3 122 ? 165.025 225.441 341.069 1.00 65.14  ? 122 GLY C N   1 
ATOM 4230 C CA  . GLY C 3 122 ? 164.068 224.525 341.655 1.00 61.89  ? 122 GLY C CA  1 
ATOM 4231 C C   . GLY C 3 122 ? 164.351 223.094 341.254 1.00 61.85  ? 122 GLY C C   1 
ATOM 4232 O O   . GLY C 3 122 ? 165.373 222.819 340.621 1.00 55.75  ? 122 GLY C O   1 
ATOM 4233 N N   . SER C 3 123 ? 163.458 222.175 341.609 1.00 60.12  ? 123 SER C N   1 
ATOM 4234 C CA  . SER C 3 123 ? 163.645 220.764 341.307 1.00 58.70  ? 123 SER C CA  1 
ATOM 4235 C C   . SER C 3 123 ? 163.143 220.442 339.907 1.00 59.88  ? 123 SER C C   1 
ATOM 4236 O O   . SER C 3 123 ? 162.280 221.132 339.360 1.00 63.45  ? 123 SER C O   1 
ATOM 4237 C CB  . SER C 3 123 ? 162.914 219.895 342.326 1.00 50.88  ? 123 SER C CB  1 
ATOM 4238 O OG  . SER C 3 123 ? 161.527 220.156 342.301 1.00 63.31  ? 123 SER C OG  1 
ATOM 4239 N N   . MET C 3 124 ? 163.696 219.373 339.328 1.00 52.15  ? 124 MET C N   1 
ATOM 4240 C CA  . MET C 3 124 ? 163.265 218.951 338.001 1.00 53.02  ? 124 MET C CA  1 
ATOM 4241 C C   . MET C 3 124 ? 161.780 218.631 337.975 1.00 57.43  ? 124 MET C C   1 
ATOM 4242 O O   . MET C 3 124 ? 161.132 218.769 336.932 1.00 58.64  ? 124 MET C O   1 
ATOM 4243 C CB  . MET C 3 124 ? 164.058 217.726 337.551 1.00 58.17  ? 124 MET C CB  1 
ATOM 4244 C CG  . MET C 3 124 ? 165.555 217.922 337.537 1.00 69.41  ? 124 MET C CG  1 
ATOM 4245 S SD  . MET C 3 124 ? 166.447 216.452 336.993 1.00 79.76  ? 124 MET C SD  1 
ATOM 4246 C CE  . MET C 3 124 ? 165.901 216.326 335.295 1.00 62.15  ? 124 MET C CE  1 
ATOM 4247 N N   . MET C 3 125 ? 161.227 218.195 339.105 1.00 63.53  ? 125 MET C N   1 
ATOM 4248 C CA  . MET C 3 125 ? 159.831 217.787 339.147 1.00 63.08  ? 125 MET C CA  1 
ATOM 4249 C C   . MET C 3 125 ? 158.881 218.977 339.152 1.00 62.53  ? 125 MET C C   1 
ATOM 4250 O O   . MET C 3 125 ? 157.741 218.850 338.696 1.00 65.86  ? 125 MET C O   1 
ATOM 4251 C CB  . MET C 3 125 ? 159.589 216.915 340.378 1.00 65.06  ? 125 MET C CB  1 
ATOM 4252 C CG  . MET C 3 125 ? 160.411 215.635 340.393 1.00 66.82  ? 125 MET C CG  1 
ATOM 4253 S SD  . MET C 3 125 ? 159.954 214.512 339.060 1.00 75.79  ? 125 MET C SD  1 
ATOM 4254 C CE  . MET C 3 125 ? 161.229 213.267 339.211 1.00 62.96  ? 125 MET C CE  1 
ATOM 4255 N N   . ALA C 3 126 ? 159.320 220.127 339.658 1.00 68.42  ? 126 ALA C N   1 
ATOM 4256 C CA  . ALA C 3 126 ? 158.451 221.295 339.708 1.00 69.12  ? 126 ALA C CA  1 
ATOM 4257 C C   . ALA C 3 126 ? 158.064 221.734 338.303 1.00 68.27  ? 126 ALA C C   1 
ATOM 4258 O O   . ALA C 3 126 ? 158.898 221.783 337.395 1.00 64.59  ? 126 ALA C O   1 
ATOM 4259 C CB  . ALA C 3 126 ? 159.143 222.441 340.442 1.00 67.21  ? 126 ALA C CB  1 
ATOM 4260 N N   . THR C 3 127 ? 156.785 222.058 338.128 1.00 65.86  ? 127 THR C N   1 
ATOM 4261 C CA  . THR C 3 127 ? 156.255 222.455 336.833 1.00 66.50  ? 127 THR C CA  1 
ATOM 4262 C C   . THR C 3 127 ? 155.325 223.644 337.015 1.00 66.12  ? 127 THR C C   1 
ATOM 4263 O O   . THR C 3 127 ? 154.755 223.850 338.089 1.00 65.87  ? 127 THR C O   1 
ATOM 4264 C CB  . THR C 3 127 ? 155.508 221.302 336.152 1.00 62.64  ? 127 THR C CB  1 
ATOM 4265 O OG1 . THR C 3 127 ? 156.249 220.089 336.318 1.00 64.69  ? 127 THR C OG1 1 
ATOM 4266 C CG2 . THR C 3 127 ? 155.339 221.574 334.669 1.00 63.06  ? 127 THR C CG2 1 
ATOM 4267 N N   . GLY C 3 128 ? 155.181 224.422 335.952 1.00 61.51  ? 128 GLY C N   1 
ATOM 4268 C CA  . GLY C 3 128 ? 154.356 225.614 335.990 1.00 55.79  ? 128 GLY C CA  1 
ATOM 4269 C C   . GLY C 3 128 ? 154.727 226.536 334.842 1.00 60.50  ? 128 GLY C C   1 
ATOM 4270 O O   . GLY C 3 128 ? 155.399 226.131 333.898 1.00 63.97  ? 128 GLY C O   1 
ATOM 4271 N N   . LYS C 3 129 ? 154.266 227.778 334.950 1.00 65.19  ? 129 LYS C N   1 
ATOM 4272 C CA  . LYS C 3 129 ? 154.572 228.797 333.960 1.00 64.78  ? 129 LYS C CA  1 
ATOM 4273 C C   . LYS C 3 129 ? 154.759 230.135 334.653 1.00 69.02  ? 129 LYS C C   1 
ATOM 4274 O O   . LYS C 3 129 ? 154.183 230.394 335.711 1.00 74.77  ? 129 LYS C O   1 
ATOM 4275 C CB  . LYS C 3 129 ? 153.472 228.921 332.901 1.00 60.57  ? 129 LYS C CB  1 
ATOM 4276 C CG  . LYS C 3 129 ? 153.462 227.806 331.881 1.00 65.22  ? 129 LYS C CG  1 
ATOM 4277 C CD  . LYS C 3 129 ? 152.396 228.036 330.831 1.00 68.07  ? 129 LYS C CD  1 
ATOM 4278 C CE  . LYS C 3 129 ? 152.347 226.896 329.833 1.00 71.71  ? 129 LYS C CE  1 
ATOM 4279 N NZ  . LYS C 3 129 ? 153.614 226.768 329.068 1.00 69.49  ? 129 LYS C NZ  1 
ATOM 4280 N N   . LEU C 3 130 ? 155.578 230.980 334.039 1.00 64.50  ? 130 LEU C N   1 
ATOM 4281 C CA  . LEU C 3 130 ? 155.796 232.347 334.475 1.00 56.82  ? 130 LEU C CA  1 
ATOM 4282 C C   . LEU C 3 130 ? 155.629 233.255 333.268 1.00 66.26  ? 130 LEU C C   1 
ATOM 4283 O O   . LEU C 3 130 ? 155.608 232.800 332.125 1.00 73.09  ? 130 LEU C O   1 
ATOM 4284 C CB  . LEU C 3 130 ? 157.183 232.520 335.104 1.00 51.80  ? 130 LEU C CB  1 
ATOM 4285 C CG  . LEU C 3 130 ? 157.383 231.788 336.430 1.00 58.57  ? 130 LEU C CG  1 
ATOM 4286 C CD1 . LEU C 3 130 ? 158.851 231.700 336.784 1.00 60.27  ? 130 LEU C CD1 1 
ATOM 4287 C CD2 . LEU C 3 130 ? 156.618 232.485 337.536 1.00 61.33  ? 130 LEU C CD2 1 
ATOM 4288 N N   . LEU C 3 131 ? 155.502 234.552 333.522 1.00 64.37  ? 131 LEU C N   1 
ATOM 4289 C CA  . LEU C 3 131 ? 155.235 235.526 332.470 1.00 58.01  ? 131 LEU C CA  1 
ATOM 4290 C C   . LEU C 3 131 ? 156.200 236.688 332.643 1.00 59.58  ? 131 LEU C C   1 
ATOM 4291 O O   . LEU C 3 131 ? 156.112 237.419 333.633 1.00 65.47  ? 131 LEU C O   1 
ATOM 4292 C CB  . LEU C 3 131 ? 153.783 235.993 332.540 1.00 60.21  ? 131 LEU C CB  1 
ATOM 4293 C CG  . LEU C 3 131 ? 153.306 237.072 331.577 1.00 63.13  ? 131 LEU C CG  1 
ATOM 4294 C CD1 . LEU C 3 131 ? 153.564 236.664 330.151 1.00 65.86  ? 131 LEU C CD1 1 
ATOM 4295 C CD2 . LEU C 3 131 ? 151.830 237.318 331.797 1.00 67.98  ? 131 LEU C CD2 1 
ATOM 4296 N N   . VAL C 3 132 ? 157.120 236.857 331.698 1.00 58.40  ? 132 VAL C N   1 
ATOM 4297 C CA  . VAL C 3 132 ? 158.102 237.933 331.746 1.00 60.94  ? 132 VAL C CA  1 
ATOM 4298 C C   . VAL C 3 132 ? 157.623 239.023 330.799 1.00 62.98  ? 132 VAL C C   1 
ATOM 4299 O O   . VAL C 3 132 ? 157.585 238.823 329.582 1.00 63.44  ? 132 VAL C O   1 
ATOM 4300 C CB  . VAL C 3 132 ? 159.502 237.442 331.360 1.00 51.95  ? 132 VAL C CB  1 
ATOM 4301 C CG1 . VAL C 3 132 ? 160.558 238.373 331.914 1.00 52.54  ? 132 VAL C CG1 1 
ATOM 4302 C CG2 . VAL C 3 132 ? 159.724 236.027 331.847 1.00 54.11  ? 132 VAL C CG2 1 
ATOM 4303 N N   . SER C 3 133 ? 157.270 240.182 331.347 1.00 65.24  ? 133 SER C N   1 
ATOM 4304 C CA  . SER C 3 133 ? 156.686 241.274 330.582 1.00 60.43  ? 133 SER C CA  1 
ATOM 4305 C C   . SER C 3 133 ? 157.632 242.462 330.567 1.00 59.51  ? 133 SER C C   1 
ATOM 4306 O O   . SER C 3 133 ? 158.299 242.744 331.566 1.00 73.88  ? 133 SER C O   1 
ATOM 4307 C CB  . SER C 3 133 ? 155.352 241.699 331.175 1.00 66.00  ? 133 SER C CB  1 
ATOM 4308 O OG  . SER C 3 133 ? 155.543 242.310 332.437 1.00 62.07  ? 133 SER C OG  1 
ATOM 4309 N N   . TYR C 3 134 ? 157.677 243.167 329.438 1.00 54.97  ? 134 TYR C N   1 
ATOM 4310 C CA  . TYR C 3 134 ? 158.549 244.322 329.255 1.00 65.23  ? 134 TYR C CA  1 
ATOM 4311 C C   . TYR C 3 134 ? 157.699 245.515 328.838 1.00 66.83  ? 134 TYR C C   1 
ATOM 4312 O O   . TYR C 3 134 ? 157.258 245.596 327.687 1.00 70.47  ? 134 TYR C O   1 
ATOM 4313 C CB  . TYR C 3 134 ? 159.625 244.029 328.213 1.00 58.82  ? 134 TYR C CB  1 
ATOM 4314 C CG  . TYR C 3 134 ? 160.217 245.267 327.587 1.00 61.34  ? 134 TYR C CG  1 
ATOM 4315 C CD1 . TYR C 3 134 ? 160.835 246.234 328.365 1.00 65.81  ? 134 TYR C CD1 1 
ATOM 4316 C CD2 . TYR C 3 134 ? 160.165 245.466 326.217 1.00 63.23  ? 134 TYR C CD2 1 
ATOM 4317 C CE1 . TYR C 3 134 ? 161.377 247.368 327.796 1.00 69.41  ? 134 TYR C CE1 1 
ATOM 4318 C CE2 . TYR C 3 134 ? 160.705 246.596 325.638 1.00 66.80  ? 134 TYR C CE2 1 
ATOM 4319 C CZ  . TYR C 3 134 ? 161.311 247.543 326.433 1.00 72.29  ? 134 TYR C CZ  1 
ATOM 4320 O OH  . TYR C 3 134 ? 161.852 248.671 325.864 1.00 69.83  ? 134 TYR C OH  1 
ATOM 4321 N N   . ALA C 3 135 ? 157.479 246.441 329.770 1.00 70.96  ? 135 ALA C N   1 
ATOM 4322 C CA  . ALA C 3 135 ? 156.763 247.673 329.475 1.00 68.16  ? 135 ALA C CA  1 
ATOM 4323 C C   . ALA C 3 135 ? 157.759 248.683 328.922 1.00 73.25  ? 135 ALA C C   1 
ATOM 4324 O O   . ALA C 3 135 ? 158.668 249.102 329.658 1.00 84.01  ? 135 ALA C O   1 
ATOM 4325 C CB  . ALA C 3 135 ? 156.094 248.217 330.726 1.00 69.38  ? 135 ALA C CB  1 
ATOM 4326 N N   . PRO C 3 136 ? 157.638 249.107 327.665 1.00 68.46  ? 136 PRO C N   1 
ATOM 4327 C CA  . PRO C 3 136 ? 158.646 249.999 327.084 1.00 68.27  ? 136 PRO C CA  1 
ATOM 4328 C C   . PRO C 3 136 ? 158.666 251.338 327.795 1.00 69.95  ? 136 PRO C C   1 
ATOM 4329 O O   . PRO C 3 136 ? 157.747 251.656 328.563 1.00 61.66  ? 136 PRO C O   1 
ATOM 4330 C CB  . PRO C 3 136 ? 158.192 250.149 325.624 1.00 59.03  ? 136 PRO C CB  1 
ATOM 4331 C CG  . PRO C 3 136 ? 157.315 248.991 325.372 1.00 68.12  ? 136 PRO C CG  1 
ATOM 4332 C CD  . PRO C 3 136 ? 156.630 248.715 326.668 1.00 70.11  ? 136 PRO C CD  1 
ATOM 4333 N N   . PRO C 3 137 ? 159.695 252.151 327.564 1.00 77.67  ? 137 PRO C N   1 
ATOM 4334 C CA  . PRO C 3 137 ? 159.772 253.442 328.250 1.00 77.55  ? 137 PRO C CA  1 
ATOM 4335 C C   . PRO C 3 137 ? 158.585 254.321 327.895 1.00 75.73  ? 137 PRO C C   1 
ATOM 4336 O O   . PRO C 3 137 ? 158.036 254.250 326.794 1.00 76.16  ? 137 PRO C O   1 
ATOM 4337 C CB  . PRO C 3 137 ? 161.092 254.037 327.748 1.00 73.53  ? 137 PRO C CB  1 
ATOM 4338 C CG  . PRO C 3 137 ? 161.368 253.339 326.472 1.00 71.59  ? 137 PRO C CG  1 
ATOM 4339 C CD  . PRO C 3 137 ? 160.801 251.964 326.612 1.00 71.36  ? 137 PRO C CD  1 
ATOM 4340 N N   . GLY C 3 138 ? 158.184 255.151 328.852 1.00 83.31  ? 138 GLY C N   1 
ATOM 4341 C CA  . GLY C 3 138 ? 156.999 255.963 328.704 1.00 85.16  ? 138 GLY C CA  1 
ATOM 4342 C C   . GLY C 3 138 ? 155.714 255.276 329.102 1.00 85.55  ? 138 GLY C C   1 
ATOM 4343 O O   . GLY C 3 138 ? 154.663 255.930 329.124 1.00 84.34  ? 138 GLY C O   1 
ATOM 4344 N N   . ALA C 3 139 ? 155.759 253.986 329.415 1.00 81.13  ? 139 ALA C N   1 
ATOM 4345 C CA  . ALA C 3 139 ? 154.596 253.256 329.887 1.00 79.37  ? 139 ALA C CA  1 
ATOM 4346 C C   . ALA C 3 139 ? 154.581 253.267 331.413 1.00 78.38  ? 139 ALA C C   1 
ATOM 4347 O O   . ALA C 3 139 ? 155.332 254.002 332.059 1.00 75.08  ? 139 ALA C O   1 
ATOM 4348 C CB  . ALA C 3 139 ? 154.602 251.836 329.328 1.00 78.46  ? 139 ALA C CB  1 
ATOM 4349 N N   . ASP C 3 140 ? 153.720 252.448 332.006 1.00 78.28  ? 140 ASP C N   1 
ATOM 4350 C CA  . ASP C 3 140 ? 153.633 252.322 333.450 1.00 80.25  ? 140 ASP C CA  1 
ATOM 4351 C C   . ASP C 3 140 ? 153.833 250.869 333.846 1.00 79.58  ? 140 ASP C C   1 
ATOM 4352 O O   . ASP C 3 140 ? 153.549 249.962 333.059 1.00 78.53  ? 140 ASP C O   1 
ATOM 4353 C CB  . ASP C 3 140 ? 152.275 252.815 333.971 1.00 77.66  ? 140 ASP C CB  1 
ATOM 4354 C CG  . ASP C 3 140 ? 152.395 254.021 334.889 1.00 81.54  ? 140 ASP C CG  1 
ATOM 4355 O OD1 . ASP C 3 140 ? 153.530 254.465 335.163 1.00 83.31  ? 140 ASP C OD1 1 
ATOM 4356 O OD2 . ASP C 3 140 ? 151.347 254.525 335.342 1.00 78.32  ? 140 ASP C OD2 1 
ATOM 4357 N N   . PRO C 3 141 ? 154.317 250.618 335.057 1.00 79.84  ? 141 PRO C N   1 
ATOM 4358 C CA  . PRO C 3 141 ? 154.584 249.246 335.471 1.00 74.85  ? 141 PRO C CA  1 
ATOM 4359 C C   . PRO C 3 141 ? 153.302 248.437 335.508 1.00 76.96  ? 141 PRO C C   1 
ATOM 4360 O O   . PRO C 3 141 ? 152.411 248.721 336.322 1.00 81.91  ? 141 PRO C O   1 
ATOM 4361 C CB  . PRO C 3 141 ? 155.178 249.412 336.877 1.00 76.19  ? 141 PRO C CB  1 
ATOM 4362 C CG  . PRO C 3 141 ? 154.615 250.688 337.368 1.00 76.67  ? 141 PRO C CG  1 
ATOM 4363 C CD  . PRO C 3 141 ? 154.510 251.572 336.163 1.00 80.35  ? 141 PRO C CD  1 
ATOM 4364 N N   . PRO C 3 142 ? 153.161 247.426 334.650 1.00 73.15  ? 142 PRO C N   1 
ATOM 4365 C CA  . PRO C 3 142 ? 151.936 246.622 334.685 1.00 76.44  ? 142 PRO C CA  1 
ATOM 4366 C C   . PRO C 3 142 ? 151.729 246.015 336.062 1.00 73.14  ? 142 PRO C C   1 
ATOM 4367 O O   . PRO C 3 142 ? 152.669 245.539 336.701 1.00 68.55  ? 142 PRO C O   1 
ATOM 4368 C CB  . PRO C 3 142 ? 152.176 245.551 333.613 1.00 72.89  ? 142 PRO C CB  1 
ATOM 4369 C CG  . PRO C 3 142 ? 153.636 245.561 333.361 1.00 70.89  ? 142 PRO C CG  1 
ATOM 4370 C CD  . PRO C 3 142 ? 154.091 246.955 333.613 1.00 71.85  ? 142 PRO C CD  1 
ATOM 4371 N N   . LYS C 3 143 ? 150.478 246.043 336.519 1.00 76.14  ? 143 LYS C N   1 
ATOM 4372 C CA  . LYS C 3 143 ? 150.133 245.645 337.878 1.00 78.69  ? 143 LYS C CA  1 
ATOM 4373 C C   . LYS C 3 143 ? 149.113 244.517 337.912 1.00 83.73  ? 143 LYS C C   1 
ATOM 4374 O O   . LYS C 3 143 ? 148.601 244.191 338.989 1.00 85.03  ? 143 LYS C O   1 
ATOM 4375 C CB  . LYS C 3 143 ? 149.609 246.853 338.659 1.00 78.82  ? 143 LYS C CB  1 
ATOM 4376 C CG  . LYS C 3 143 ? 148.501 247.621 337.948 1.00 85.21  ? 143 LYS C CG  1 
ATOM 4377 C CD  . LYS C 3 143 ? 148.192 248.949 338.627 1.00 86.72  ? 143 LYS C CD  1 
ATOM 4378 C CE  . LYS C 3 143 ? 149.359 249.929 338.542 1.00 86.64  ? 143 LYS C CE  1 
ATOM 4379 N NZ  . LYS C 3 143 ? 149.853 250.121 337.150 1.00 84.22  ? 143 LYS C NZ  1 
ATOM 4380 N N   . LYS C 3 144 ? 148.802 243.918 336.766 1.00 88.16  ? 144 LYS C N   1 
ATOM 4381 C CA  . LYS C 3 144 ? 147.944 242.746 336.719 1.00 87.93  ? 144 LYS C CA  1 
ATOM 4382 C C   . LYS C 3 144 ? 148.413 241.855 335.583 1.00 82.09  ? 144 LYS C C   1 
ATOM 4383 O O   . LYS C 3 144 ? 149.048 242.312 334.630 1.00 87.80  ? 144 LYS C O   1 
ATOM 4384 C CB  . LYS C 3 144 ? 146.468 243.124 336.537 1.00 90.53  ? 144 LYS C CB  1 
ATOM 4385 C CG  . LYS C 3 144 ? 145.877 243.919 337.693 1.00 92.16  ? 144 LYS C CG  1 
ATOM 4386 C CD  . LYS C 3 144 ? 145.803 243.096 338.971 1.00 89.98  ? 144 LYS C CD  1 
ATOM 4387 C CE  . LYS C 3 144 ? 145.497 243.967 340.176 1.00 89.52  ? 144 LYS C CE  1 
ATOM 4388 N NZ  . LYS C 3 144 ? 146.600 244.927 340.461 1.00 90.42  ? 144 LYS C NZ  1 
ATOM 4389 N N   . ARG C 3 145 ? 148.090 240.568 335.697 1.00 69.83  ? 145 ARG C N   1 
ATOM 4390 C CA  . ARG C 3 145 ? 148.594 239.596 334.735 1.00 73.33  ? 145 ARG C CA  1 
ATOM 4391 C C   . ARG C 3 145 ? 148.078 239.889 333.331 1.00 77.52  ? 145 ARG C C   1 
ATOM 4392 O O   . ARG C 3 145 ? 148.829 239.796 332.355 1.00 74.20  ? 145 ARG C O   1 
ATOM 4393 C CB  . ARG C 3 145 ? 148.204 238.187 335.179 1.00 72.98  ? 145 ARG C CB  1 
ATOM 4394 C CG  . ARG C 3 145 ? 149.135 237.086 334.697 1.00 63.46  ? 145 ARG C CG  1 
ATOM 4395 C CD  . ARG C 3 145 ? 148.865 236.695 333.258 1.00 67.51  ? 145 ARG C CD  1 
ATOM 4396 N NE  . ARG C 3 145 ? 147.491 236.249 333.064 1.00 76.26  ? 145 ARG C NE  1 
ATOM 4397 C CZ  . ARG C 3 145 ? 146.954 235.964 331.886 1.00 76.65  ? 145 ARG C CZ  1 
ATOM 4398 N NH1 . ARG C 3 145 ? 147.652 236.056 330.767 1.00 76.11  ? 145 ARG C NH1 1 
ATOM 4399 N NH2 . ARG C 3 145 ? 145.683 235.577 331.831 1.00 74.23  ? 145 ARG C NH2 1 
ATOM 4400 N N   . LYS C 3 146 ? 146.800 240.253 333.211 1.00 84.51  ? 146 LYS C N   1 
ATOM 4401 C CA  . LYS C 3 146 ? 146.203 240.456 331.893 1.00 78.40  ? 146 LYS C CA  1 
ATOM 4402 C C   . LYS C 3 146 ? 146.886 241.596 331.146 1.00 78.68  ? 146 LYS C C   1 
ATOM 4403 O O   . LYS C 3 146 ? 147.209 241.473 329.958 1.00 76.10  ? 146 LYS C O   1 
ATOM 4404 C CB  . LYS C 3 146 ? 144.706 240.730 332.048 1.00 76.91  ? 146 LYS C CB  1 
ATOM 4405 C CG  . LYS C 3 146 ? 143.955 240.954 330.744 1.00 80.24  ? 146 LYS C CG  1 
ATOM 4406 C CD  . LYS C 3 146 ? 142.527 241.409 331.014 1.00 83.56  ? 146 LYS C CD  1 
ATOM 4407 C CE  . LYS C 3 146 ? 141.783 241.742 329.732 1.00 81.30  ? 146 LYS C CE  1 
ATOM 4408 N NZ  . LYS C 3 146 ? 141.542 240.539 328.893 1.00 84.90  ? 146 LYS C NZ  1 
ATOM 4409 N N   . GLU C 3 147 ? 147.116 242.718 331.831 1.00 86.65  ? 147 GLU C N   1 
ATOM 4410 C CA  . GLU C 3 147 ? 147.746 243.861 331.180 1.00 82.63  ? 147 GLU C CA  1 
ATOM 4411 C C   . GLU C 3 147 ? 149.150 243.513 330.712 1.00 84.48  ? 147 GLU C C   1 
ATOM 4412 O O   . GLU C 3 147 ? 149.551 243.871 329.599 1.00 85.40  ? 147 GLU C O   1 
ATOM 4413 C CB  . GLU C 3 147 ? 147.782 245.055 332.131 1.00 79.73  ? 147 GLU C CB  1 
ATOM 4414 C CG  . GLU C 3 147 ? 146.441 245.742 332.319 1.00 83.33  ? 147 GLU C CG  1 
ATOM 4415 C CD  . GLU C 3 147 ? 145.412 244.854 332.987 1.00 82.82  ? 147 GLU C CD  1 
ATOM 4416 O OE1 . GLU C 3 147 ? 145.756 243.710 333.348 1.00 84.69  ? 147 GLU C OE1 1 
ATOM 4417 O OE2 . GLU C 3 147 ? 144.257 245.299 333.150 1.00 81.62  ? 147 GLU C OE2 1 
ATOM 4418 N N   . ALA C 3 148 ? 149.910 242.806 331.548 1.00 73.11  ? 148 ALA C N   1 
ATOM 4419 C CA  . ALA C 3 148 ? 151.239 242.369 331.143 1.00 65.37  ? 148 ALA C CA  1 
ATOM 4420 C C   . ALA C 3 148 ? 151.163 241.438 329.943 1.00 67.94  ? 148 ALA C C   1 
ATOM 4421 O O   . ALA C 3 148 ? 152.016 241.490 329.051 1.00 64.59  ? 148 ALA C O   1 
ATOM 4422 C CB  . ALA C 3 148 ? 151.934 241.681 332.313 1.00 64.46  ? 148 ALA C CB  1 
ATOM 4423 N N   . MET C 3 149 ? 150.147 240.575 329.906 1.00 76.81  ? 149 MET C N   1 
ATOM 4424 C CA  . MET C 3 149 ? 149.994 239.661 328.780 1.00 77.48  ? 149 MET C CA  1 
ATOM 4425 C C   . MET C 3 149 ? 149.661 240.416 327.502 1.00 82.29  ? 149 MET C C   1 
ATOM 4426 O O   . MET C 3 149 ? 149.998 239.967 326.401 1.00 82.47  ? 149 MET C O   1 
ATOM 4427 C CB  . MET C 3 149 ? 148.912 238.628 329.091 1.00 74.51  ? 149 MET C CB  1 
ATOM 4428 C CG  . MET C 3 149 ? 148.634 237.646 327.962 1.00 74.66  ? 149 MET C CG  1 
ATOM 4429 S SD  . MET C 3 149 ? 147.505 238.269 326.698 1.00 93.32  ? 149 MET C SD  1 
ATOM 4430 C CE  . MET C 3 149 ? 145.961 238.349 327.605 1.00 81.24  ? 149 MET C CE  1 
ATOM 4431 N N   . LEU C 3 150 ? 148.979 241.555 327.620 1.00 75.35  ? 150 LEU C N   1 
ATOM 4432 C CA  . LEU C 3 150 ? 148.633 242.321 326.429 1.00 68.65  ? 150 LEU C CA  1 
ATOM 4433 C C   . LEU C 3 150 ? 149.820 243.071 325.840 1.00 69.23  ? 150 LEU C C   1 
ATOM 4434 O O   . LEU C 3 150 ? 149.729 243.533 324.700 1.00 73.61  ? 150 LEU C O   1 
ATOM 4435 C CB  . LEU C 3 150 ? 147.508 243.306 326.747 1.00 75.99  ? 150 LEU C CB  1 
ATOM 4436 C CG  . LEU C 3 150 ? 146.105 242.697 326.816 1.00 76.78  ? 150 LEU C CG  1 
ATOM 4437 C CD1 . LEU C 3 150 ? 145.119 243.674 327.425 1.00 69.76  ? 150 LEU C CD1 1 
ATOM 4438 C CD2 . LEU C 3 150 ? 145.639 242.270 325.436 1.00 75.16  ? 150 LEU C CD2 1 
ATOM 4439 N N   . GLY C 3 151 ? 150.916 243.204 326.575 1.00 71.88  ? 151 GLY C N   1 
ATOM 4440 C CA  . GLY C 3 151 ? 152.085 243.931 326.115 1.00 71.82  ? 151 GLY C CA  1 
ATOM 4441 C C   . GLY C 3 151 ? 153.081 243.047 325.400 1.00 71.28  ? 151 GLY C C   1 
ATOM 4442 O O   . GLY C 3 151 ? 152.717 242.127 324.661 1.00 73.51  ? 151 GLY C O   1 
ATOM 4443 N N   . THR C 3 152 ? 154.363 243.338 325.613 1.00 61.99  ? 152 THR C N   1 
ATOM 4444 C CA  . THR C 3 152 ? 155.451 242.549 325.039 1.00 65.20  ? 152 THR C CA  1 
ATOM 4445 C C   . THR C 3 152 ? 155.941 241.583 326.105 1.00 67.91  ? 152 THR C C   1 
ATOM 4446 O O   . THR C 3 152 ? 156.679 241.967 327.014 1.00 73.10  ? 152 THR C O   1 
ATOM 4447 C CB  . THR C 3 152 ? 156.582 243.447 324.553 1.00 66.41  ? 152 THR C CB  1 
ATOM 4448 O OG1 . THR C 3 152 ? 156.069 244.413 323.628 1.00 70.41  ? 152 THR C OG1 1 
ATOM 4449 C CG2 . THR C 3 152 ? 157.658 242.621 323.872 1.00 64.05  ? 152 THR C CG2 1 
ATOM 4450 N N   . HIS C 3 153 ? 155.551 240.319 325.989 1.00 59.04  ? 153 HIS C N   1 
ATOM 4451 C CA  . HIS C 3 153 ? 155.831 239.338 327.022 1.00 57.76  ? 153 HIS C CA  1 
ATOM 4452 C C   . HIS C 3 153 ? 156.373 238.061 326.404 1.00 58.30  ? 153 HIS C C   1 
ATOM 4453 O O   . HIS C 3 153 ? 156.279 237.830 325.196 1.00 65.07  ? 153 HIS C O   1 
ATOM 4454 C CB  . HIS C 3 153 ? 154.575 239.017 327.835 1.00 59.32  ? 153 HIS C CB  1 
ATOM 4455 C CG  . HIS C 3 153 ? 153.570 238.204 327.085 1.00 59.39  ? 153 HIS C CG  1 
ATOM 4456 N ND1 . HIS C 3 153 ? 153.676 236.839 326.937 1.00 61.37  ? 153 HIS C ND1 1 
ATOM 4457 C CD2 . HIS C 3 153 ? 152.442 238.565 326.432 1.00 64.09  ? 153 HIS C CD2 1 
ATOM 4458 C CE1 . HIS C 3 153 ? 152.654 236.393 326.229 1.00 61.28  ? 153 HIS C CE1 1 
ATOM 4459 N NE2 . HIS C 3 153 ? 151.890 237.421 325.910 1.00 64.94  ? 153 HIS C NE2 1 
ATOM 4460 N N   . VAL C 3 154 ? 156.956 237.236 327.267 1.00 56.48  ? 154 VAL C N   1 
ATOM 4461 C CA  . VAL C 3 154 ? 157.352 235.874 326.938 1.00 59.70  ? 154 VAL C CA  1 
ATOM 4462 C C   . VAL C 3 154 ? 156.862 234.964 328.054 1.00 56.96  ? 154 VAL C C   1 
ATOM 4463 O O   . VAL C 3 154 ? 157.087 235.246 329.237 1.00 58.75  ? 154 VAL C O   1 
ATOM 4464 C CB  . VAL C 3 154 ? 158.875 235.739 326.755 1.00 56.82  ? 154 VAL C CB  1 
ATOM 4465 C CG1 . VAL C 3 154 ? 159.609 236.274 327.964 1.00 60.05  ? 154 VAL C CG1 1 
ATOM 4466 C CG2 . VAL C 3 154 ? 159.248 234.293 326.519 1.00 60.39  ? 154 VAL C CG2 1 
ATOM 4467 N N   . ILE C 3 155 ? 156.177 233.892 327.681 1.00 60.45  ? 155 ILE C N   1 
ATOM 4468 C CA  . ILE C 3 155 ? 155.740 232.882 328.635 1.00 59.66  ? 155 ILE C CA  1 
ATOM 4469 C C   . ILE C 3 155 ? 156.882 231.899 328.835 1.00 64.06  ? 155 ILE C C   1 
ATOM 4470 O O   . ILE C 3 155 ? 157.392 231.314 327.873 1.00 68.23  ? 155 ILE C O   1 
ATOM 4471 C CB  . ILE C 3 155 ? 154.470 232.168 328.147 1.00 55.44  ? 155 ILE C CB  1 
ATOM 4472 C CG1 . ILE C 3 155 ? 153.248 233.070 328.319 1.00 57.66  ? 155 ILE C CG1 1 
ATOM 4473 C CG2 . ILE C 3 155 ? 154.273 230.864 328.895 1.00 57.13  ? 155 ILE C CG2 1 
ATOM 4474 C CD1 . ILE C 3 155 ? 152.711 233.112 329.728 1.00 60.75  ? 155 ILE C CD1 1 
ATOM 4475 N N   . TRP C 3 156 ? 157.279 231.720 330.082 1.00 55.36  ? 156 TRP C N   1 
ATOM 4476 C CA  . TRP C 3 156 ? 158.458 230.954 330.457 1.00 52.27  ? 156 TRP C CA  1 
ATOM 4477 C C   . TRP C 3 156 ? 157.977 229.707 331.189 1.00 59.91  ? 156 TRP C C   1 
ATOM 4478 O O   . TRP C 3 156 ? 157.622 229.768 332.369 1.00 68.78  ? 156 TRP C O   1 
ATOM 4479 C CB  . TRP C 3 156 ? 159.370 231.817 331.319 1.00 56.09  ? 156 TRP C CB  1 
ATOM 4480 C CG  . TRP C 3 156 ? 160.489 231.103 331.970 1.00 58.44  ? 156 TRP C CG  1 
ATOM 4481 C CD1 . TRP C 3 156 ? 161.113 229.975 331.538 1.00 57.29  ? 156 TRP C CD1 1 
ATOM 4482 C CD2 . TRP C 3 156 ? 161.128 231.476 333.190 1.00 56.02  ? 156 TRP C CD2 1 
ATOM 4483 N NE1 . TRP C 3 156 ? 162.105 229.622 332.416 1.00 61.73  ? 156 TRP C NE1 1 
ATOM 4484 C CE2 . TRP C 3 156 ? 162.131 230.529 333.441 1.00 56.47  ? 156 TRP C CE2 1 
ATOM 4485 C CE3 . TRP C 3 156 ? 160.945 232.521 334.097 1.00 54.07  ? 156 TRP C CE3 1 
ATOM 4486 C CZ2 . TRP C 3 156 ? 162.949 230.595 334.558 1.00 59.06  ? 156 TRP C CZ2 1 
ATOM 4487 C CZ3 . TRP C 3 156 ? 161.753 232.584 335.202 1.00 56.93  ? 156 TRP C CZ3 1 
ATOM 4488 C CH2 . TRP C 3 156 ? 162.745 231.629 335.426 1.00 60.65  ? 156 TRP C CH2 1 
ATOM 4489 N N   . ASP C 3 157 ? 157.956 228.582 330.481 1.00 70.14  ? 157 ASP C N   1 
ATOM 4490 C CA  . ASP C 3 157 ? 157.500 227.318 331.049 1.00 67.46  ? 157 ASP C CA  1 
ATOM 4491 C C   . ASP C 3 157 ? 158.656 226.706 331.823 1.00 69.65  ? 157 ASP C C   1 
ATOM 4492 O O   . ASP C 3 157 ? 159.511 226.026 331.252 1.00 73.58  ? 157 ASP C O   1 
ATOM 4493 C CB  . ASP C 3 157 ? 157.009 226.381 329.953 1.00 69.20  ? 157 ASP C CB  1 
ATOM 4494 C CG  . ASP C 3 157 ? 156.254 225.188 330.502 1.00 80.21  ? 157 ASP C CG  1 
ATOM 4495 O OD1 . ASP C 3 157 ? 156.489 224.821 331.672 1.00 83.25  ? 157 ASP C OD1 1 
ATOM 4496 O OD2 . ASP C 3 157 ? 155.423 224.618 329.765 1.00 82.06  ? 157 ASP C OD2 1 
ATOM 4497 N N   . ILE C 3 158 ? 158.684 226.942 333.136 1.00 62.79  ? 158 ILE C N   1 
ATOM 4498 C CA  . ILE C 3 158 ? 159.791 226.467 333.955 1.00 59.84  ? 158 ILE C CA  1 
ATOM 4499 C C   . ILE C 3 158 ? 159.923 224.956 333.900 1.00 62.34  ? 158 ILE C C   1 
ATOM 4500 O O   . ILE C 3 158 ? 161.007 224.421 334.147 1.00 73.15  ? 158 ILE C O   1 
ATOM 4501 C CB  . ILE C 3 158 ? 159.616 226.941 335.409 1.00 62.86  ? 158 ILE C CB  1 
ATOM 4502 C CG1 . ILE C 3 158 ? 158.335 226.365 336.008 1.00 67.25  ? 158 ILE C CG1 1 
ATOM 4503 C CG2 . ILE C 3 158 ? 159.589 228.450 335.465 1.00 64.60  ? 158 ILE C CG2 1 
ATOM 4504 C CD1 . ILE C 3 158 ? 158.083 226.800 337.426 1.00 68.00  ? 158 ILE C CD1 1 
ATOM 4505 N N   . GLY C 3 159 ? 158.842 224.245 333.584 1.00 59.22  ? 159 GLY C N   1 
ATOM 4506 C CA  . GLY C 3 159 ? 158.910 222.794 333.572 1.00 63.21  ? 159 GLY C CA  1 
ATOM 4507 C C   . GLY C 3 159 ? 159.921 222.266 332.575 1.00 66.36  ? 159 GLY C C   1 
ATOM 4508 O O   . GLY C 3 159 ? 160.726 221.389 332.893 1.00 68.84  ? 159 GLY C O   1 
ATOM 4509 N N   . LEU C 3 160 ? 159.897 222.796 331.353 1.00 69.39  ? 160 LEU C N   1 
ATOM 4510 C CA  . LEU C 3 160 ? 160.765 222.318 330.288 1.00 70.39  ? 160 LEU C CA  1 
ATOM 4511 C C   . LEU C 3 160 ? 161.907 223.270 329.961 1.00 67.42  ? 160 LEU C C   1 
ATOM 4512 O O   . LEU C 3 160 ? 162.750 222.930 329.125 1.00 68.26  ? 160 LEU C O   1 
ATOM 4513 C CB  . LEU C 3 160 ? 159.942 222.050 329.019 1.00 69.28  ? 160 LEU C CB  1 
ATOM 4514 C CG  . LEU C 3 160 ? 159.148 223.227 328.456 1.00 73.59  ? 160 LEU C CG  1 
ATOM 4515 C CD1 . LEU C 3 160 ? 159.850 223.814 327.251 1.00 72.82  ? 160 LEU C CD1 1 
ATOM 4516 C CD2 . LEU C 3 160 ? 157.740 222.796 328.095 1.00 71.22  ? 160 LEU C CD2 1 
ATOM 4517 N N   . GLN C 3 161 ? 161.956 224.441 330.586 1.00 63.54  ? 161 GLN C N   1 
ATOM 4518 C CA  . GLN C 3 161 ? 163.087 225.347 330.473 1.00 62.70  ? 161 GLN C CA  1 
ATOM 4519 C C   . GLN C 3 161 ? 163.471 225.824 331.863 1.00 65.72  ? 161 GLN C C   1 
ATOM 4520 O O   . GLN C 3 161 ? 162.622 225.951 332.746 1.00 74.64  ? 161 GLN C O   1 
ATOM 4521 C CB  . GLN C 3 161 ? 162.769 226.550 329.579 1.00 62.25  ? 161 GLN C CB  1 
ATOM 4522 C CG  . GLN C 3 161 ? 162.587 226.198 328.117 1.00 66.80  ? 161 GLN C CG  1 
ATOM 4523 C CD  . GLN C 3 161 ? 163.796 225.499 327.531 1.00 75.60  ? 161 GLN C CD  1 
ATOM 4524 O OE1 . GLN C 3 161 ? 163.705 224.366 327.062 1.00 71.26  ? 161 GLN C OE1 1 
ATOM 4525 N NE2 . GLN C 3 161 ? 164.939 226.174 327.553 1.00 77.64  ? 161 GLN C NE2 1 
ATOM 4526 N N   . SER C 3 162 ? 164.762 226.083 332.053 1.00 54.33  ? 162 SER C N   1 
ATOM 4527 C CA  . SER C 3 162 ? 165.273 226.510 333.344 1.00 54.87  ? 162 SER C CA  1 
ATOM 4528 C C   . SER C 3 162 ? 165.744 227.955 333.363 1.00 61.14  ? 162 SER C C   1 
ATOM 4529 O O   . SER C 3 162 ? 165.900 228.518 334.451 1.00 62.76  ? 162 SER C O   1 
ATOM 4530 C CB  . SER C 3 162 ? 166.430 225.604 333.780 1.00 58.75  ? 162 SER C CB  1 
ATOM 4531 O OG  . SER C 3 162 ? 166.940 226.012 335.036 1.00 60.98  ? 162 SER C OG  1 
ATOM 4532 N N   . SER C 3 163 ? 165.978 228.566 332.205 1.00 61.81  ? 163 SER C N   1 
ATOM 4533 C CA  . SER C 3 163 ? 166.429 229.949 332.144 1.00 57.84  ? 163 SER C CA  1 
ATOM 4534 C C   . SER C 3 163 ? 165.738 230.652 330.989 1.00 61.10  ? 163 SER C C   1 
ATOM 4535 O O   . SER C 3 163 ? 165.657 230.106 329.886 1.00 66.06  ? 163 SER C O   1 
ATOM 4536 C CB  . SER C 3 163 ? 167.946 230.033 331.972 1.00 62.08  ? 163 SER C CB  1 
ATOM 4537 O OG  . SER C 3 163 ? 168.326 229.668 330.658 1.00 68.66  ? 163 SER C OG  1 
ATOM 4538 N N   . CYS C 3 164 ? 165.253 231.862 331.248 1.00 64.74  ? 164 CYS C N   1 
ATOM 4539 C CA  . CYS C 3 164 ? 164.574 232.678 330.250 1.00 60.40  ? 164 CYS C CA  1 
ATOM 4540 C C   . CYS C 3 164 ? 165.340 233.975 330.055 1.00 63.73  ? 164 CYS C C   1 
ATOM 4541 O O   . CYS C 3 164 ? 165.640 234.673 331.028 1.00 65.68  ? 164 CYS C O   1 
ATOM 4542 C CB  . CYS C 3 164 ? 163.137 232.979 330.668 1.00 59.54  ? 164 CYS C CB  1 
ATOM 4543 S SG  . CYS C 3 164 ? 162.267 234.096 329.554 1.00 76.13  ? 164 CYS C SG  1 
ATOM 4544 N N   . THR C 3 165 ? 165.641 234.301 328.803 1.00 63.90  ? 165 THR C N   1 
ATOM 4545 C CA  . THR C 3 165 ? 166.433 235.473 328.463 1.00 58.60  ? 165 THR C CA  1 
ATOM 4546 C C   . THR C 3 165 ? 165.571 236.491 327.731 1.00 58.09  ? 165 THR C C   1 
ATOM 4547 O O   . THR C 3 165 ? 164.759 236.132 326.872 1.00 62.88  ? 165 THR C O   1 
ATOM 4548 C CB  . THR C 3 165 ? 167.630 235.091 327.594 1.00 59.00  ? 165 THR C CB  1 
ATOM 4549 O OG1 . THR C 3 165 ? 168.303 233.968 328.173 1.00 61.89  ? 165 THR C OG1 1 
ATOM 4550 C CG2 . THR C 3 165 ? 168.598 236.251 327.489 1.00 60.78  ? 165 THR C CG2 1 
ATOM 4551 N N   . MET C 3 166 ? 165.755 237.762 328.076 1.00 64.38  ? 166 MET C N   1 
ATOM 4552 C CA  . MET C 3 166 ? 164.986 238.854 327.495 1.00 59.82  ? 166 MET C CA  1 
ATOM 4553 C C   . MET C 3 166 ? 165.933 240.006 327.211 1.00 62.54  ? 166 MET C C   1 
ATOM 4554 O O   . MET C 3 166 ? 166.593 240.505 328.126 1.00 69.45  ? 166 MET C O   1 
ATOM 4555 C CB  . MET C 3 166 ? 163.864 239.292 328.440 1.00 55.11  ? 166 MET C CB  1 
ATOM 4556 C CG  . MET C 3 166 ? 163.206 240.601 328.057 1.00 66.14  ? 166 MET C CG  1 
ATOM 4557 S SD  . MET C 3 166 ? 161.510 240.719 328.650 1.00 91.46  ? 166 MET C SD  1 
ATOM 4558 C CE  . MET C 3 166 ? 160.688 239.604 327.516 1.00 67.30  ? 166 MET C CE  1 
ATOM 4559 N N   . VAL C 3 167 ? 166.003 240.422 325.952 1.00 49.21  ? 167 VAL C N   1 
ATOM 4560 C CA  . VAL C 3 167 ? 166.897 241.488 325.517 1.00 47.43  ? 167 VAL C CA  1 
ATOM 4561 C C   . VAL C 3 167 ? 166.060 242.753 325.382 1.00 46.19  ? 167 VAL C C   1 
ATOM 4562 O O   . VAL C 3 167 ? 165.290 242.905 324.432 1.00 57.83  ? 167 VAL C O   1 
ATOM 4563 C CB  . VAL C 3 167 ? 167.602 241.138 324.206 1.00 42.60  ? 167 VAL C CB  1 
ATOM 4564 C CG1 . VAL C 3 167 ? 168.189 242.382 323.575 1.00 48.69  ? 167 VAL C CG1 1 
ATOM 4565 C CG2 . VAL C 3 167 ? 168.684 240.109 324.450 1.00 52.63  ? 167 VAL C CG2 1 
ATOM 4566 N N   . VAL C 3 168 ? 166.216 243.670 326.329 1.00 50.99  ? 168 VAL C N   1 
ATOM 4567 C CA  . VAL C 3 168 ? 165.521 244.950 326.278 1.00 53.41  ? 168 VAL C CA  1 
ATOM 4568 C C   . VAL C 3 168 ? 166.109 245.762 325.132 1.00 59.15  ? 168 VAL C C   1 
ATOM 4569 O O   . VAL C 3 168 ? 167.314 246.046 325.141 1.00 63.41  ? 168 VAL C O   1 
ATOM 4570 C CB  . VAL C 3 168 ? 165.649 245.700 327.610 1.00 52.01  ? 168 VAL C CB  1 
ATOM 4571 C CG1 . VAL C 3 168 ? 165.220 247.141 327.450 1.00 53.32  ? 168 VAL C CG1 1 
ATOM 4572 C CG2 . VAL C 3 168 ? 164.823 245.011 328.672 1.00 52.32  ? 168 VAL C CG2 1 
ATOM 4573 N N   . PRO C 3 169 ? 165.322 246.169 324.141 1.00 56.10  ? 169 PRO C N   1 
ATOM 4574 C CA  . PRO C 3 169 ? 165.885 246.914 323.015 1.00 50.79  ? 169 PRO C CA  1 
ATOM 4575 C C   . PRO C 3 169 ? 166.221 248.346 323.399 1.00 60.65  ? 169 PRO C C   1 
ATOM 4576 O O   . PRO C 3 169 ? 165.725 248.894 324.384 1.00 64.87  ? 169 PRO C O   1 
ATOM 4577 C CB  . PRO C 3 169 ? 164.766 246.870 321.974 1.00 51.96  ? 169 PRO C CB  1 
ATOM 4578 C CG  . PRO C 3 169 ? 163.532 246.807 322.782 1.00 54.78  ? 169 PRO C CG  1 
ATOM 4579 C CD  . PRO C 3 169 ? 163.867 245.995 324.001 1.00 56.49  ? 169 PRO C CD  1 
ATOM 4580 N N   . TRP C 3 170 ? 167.087 248.951 322.591 1.00 59.28  ? 170 TRP C N   1 
ATOM 4581 C CA  . TRP C 3 170 ? 167.504 250.335 322.797 1.00 54.71  ? 170 TRP C CA  1 
ATOM 4582 C C   . TRP C 3 170 ? 166.556 251.234 322.017 1.00 59.63  ? 170 TRP C C   1 
ATOM 4583 O O   . TRP C 3 170 ? 166.653 251.348 320.794 1.00 64.71  ? 170 TRP C O   1 
ATOM 4584 C CB  . TRP C 3 170 ? 168.948 250.539 322.359 1.00 58.35  ? 170 TRP C CB  1 
ATOM 4585 C CG  . TRP C 3 170 ? 169.360 251.973 322.333 1.00 53.76  ? 170 TRP C CG  1 
ATOM 4586 C CD1 . TRP C 3 170 ? 169.832 252.669 321.261 1.00 47.66  ? 170 TRP C CD1 1 
ATOM 4587 C CD2 . TRP C 3 170 ? 169.330 252.894 323.425 1.00 57.71  ? 170 TRP C CD2 1 
ATOM 4588 N NE1 . TRP C 3 170 ? 170.101 253.964 321.621 1.00 50.57  ? 170 TRP C NE1 1 
ATOM 4589 C CE2 . TRP C 3 170 ? 169.801 254.128 322.945 1.00 55.08  ? 170 TRP C CE2 1 
ATOM 4590 C CE3 . TRP C 3 170 ? 168.952 252.793 324.767 1.00 62.71  ? 170 TRP C CE3 1 
ATOM 4591 C CZ2 . TRP C 3 170 ? 169.903 255.251 323.755 1.00 56.41  ? 170 TRP C CZ2 1 
ATOM 4592 C CZ3 . TRP C 3 170 ? 169.054 253.910 325.568 1.00 60.80  ? 170 TRP C CZ3 1 
ATOM 4593 C CH2 . TRP C 3 170 ? 169.526 255.123 325.061 1.00 57.02  ? 170 TRP C CH2 1 
ATOM 4594 N N   . ILE C 3 171 ? 165.633 251.872 322.728 1.00 61.25  ? 171 ILE C N   1 
ATOM 4595 C CA  . ILE C 3 171 ? 164.680 252.801 322.140 1.00 60.39  ? 171 ILE C CA  1 
ATOM 4596 C C   . ILE C 3 171 ? 164.843 254.132 322.856 1.00 61.21  ? 171 ILE C C   1 
ATOM 4597 O O   . ILE C 3 171 ? 164.742 254.197 324.087 1.00 63.19  ? 171 ILE C O   1 
ATOM 4598 C CB  . ILE C 3 171 ? 163.236 252.281 322.244 1.00 58.70  ? 171 ILE C CB  1 
ATOM 4599 C CG1 . ILE C 3 171 ? 162.270 253.195 321.490 1.00 61.62  ? 171 ILE C CG1 1 
ATOM 4600 C CG2 . ILE C 3 171 ? 162.809 252.159 323.696 1.00 65.56  ? 171 ILE C CG2 1 
ATOM 4601 C CD1 . ILE C 3 171 ? 162.452 253.172 319.989 1.00 64.30  ? 171 ILE C CD1 1 
ATOM 4602 N N   . SER C 3 172 ? 165.116 255.186 322.093 1.00 57.58  ? 172 SER C N   1 
ATOM 4603 C CA  . SER C 3 172 ? 165.287 256.511 322.668 1.00 60.54  ? 172 SER C CA  1 
ATOM 4604 C C   . SER C 3 172 ? 165.411 257.525 321.545 1.00 62.16  ? 172 SER C C   1 
ATOM 4605 O O   . SER C 3 172 ? 165.892 257.206 320.454 1.00 63.43  ? 172 SER C O   1 
ATOM 4606 C CB  . SER C 3 172 ? 166.519 256.578 323.574 1.00 60.35  ? 172 SER C CB  1 
ATOM 4607 O OG  . SER C 3 172 ? 166.671 257.874 324.120 1.00 62.63  ? 172 SER C OG  1 
ATOM 4608 N N   . ASN C 3 173 ? 164.971 258.751 321.831 1.00 57.60  ? 173 ASN C N   1 
ATOM 4609 C CA  . ASN C 3 173 ? 165.070 259.827 320.850 1.00 57.77  ? 173 ASN C CA  1 
ATOM 4610 C C   . ASN C 3 173 ? 166.523 260.198 320.582 1.00 56.14  ? 173 ASN C C   1 
ATOM 4611 O O   . ASN C 3 173 ? 166.947 260.297 319.425 1.00 49.95  ? 173 ASN C O   1 
ATOM 4612 C CB  . ASN C 3 173 ? 164.285 261.044 321.339 1.00 58.90  ? 173 ASN C CB  1 
ATOM 4613 C CG  . ASN C 3 173 ? 164.589 261.394 322.776 1.00 60.97  ? 173 ASN C CG  1 
ATOM 4614 O OD1 . ASN C 3 173 ? 165.522 260.858 323.369 1.00 60.54  ? 173 ASN C OD1 1 
ATOM 4615 N ND2 . ASN C 3 173 ? 163.799 262.293 323.346 1.00 55.37  ? 173 ASN C ND2 1 
ATOM 4616 N N   . THR C 3 174 ? 167.303 260.402 321.640 1.00 64.53  ? 174 THR C N   1 
ATOM 4617 C CA  . THR C 3 174 ? 168.693 260.803 321.505 1.00 59.54  ? 174 THR C CA  1 
ATOM 4618 C C   . THR C 3 174 ? 169.568 259.600 321.159 1.00 62.55  ? 174 THR C C   1 
ATOM 4619 O O   . THR C 3 174 ? 169.139 258.445 321.213 1.00 59.68  ? 174 THR C O   1 
ATOM 4620 C CB  . THR C 3 174 ? 169.192 261.451 322.795 1.00 50.17  ? 174 THR C CB  1 
ATOM 4621 O OG1 . THR C 3 174 ? 169.170 260.488 323.853 1.00 61.77  ? 174 THR C OG1 1 
ATOM 4622 C CG2 . THR C 3 174 ? 168.315 262.623 323.181 1.00 51.97  ? 174 THR C CG2 1 
ATOM 4623 N N   . THR C 3 175 ? 170.814 259.885 320.786 1.00 55.53  ? 175 THR C N   1 
ATOM 4624 C CA  . THR C 3 175 ? 171.801 258.832 320.601 1.00 53.22  ? 175 THR C CA  1 
ATOM 4625 C C   . THR C 3 175 ? 172.402 258.366 321.918 1.00 56.35  ? 175 THR C C   1 
ATOM 4626 O O   . THR C 3 175 ? 173.032 257.305 321.952 1.00 57.16  ? 175 THR C O   1 
ATOM 4627 C CB  . THR C 3 175 ? 172.927 259.308 319.681 1.00 58.00  ? 175 THR C CB  1 
ATOM 4628 O OG1 . THR C 3 175 ? 173.632 260.387 320.305 1.00 64.40  ? 175 THR C OG1 1 
ATOM 4629 C CG2 . THR C 3 175 ? 172.371 259.777 318.350 1.00 61.75  ? 175 THR C CG2 1 
ATOM 4630 N N   . TYR C 3 176 ? 172.218 259.129 322.992 1.00 60.47  ? 176 TYR C N   1 
ATOM 4631 C CA  . TYR C 3 176 ? 172.779 258.795 324.292 1.00 51.66  ? 176 TYR C CA  1 
ATOM 4632 C C   . TYR C 3 176 ? 171.868 259.349 325.373 1.00 49.43  ? 176 TYR C C   1 
ATOM 4633 O O   . TYR C 3 176 ? 171.571 260.545 325.380 1.00 63.99  ? 176 TYR C O   1 
ATOM 4634 C CB  . TYR C 3 176 ? 174.187 259.368 324.451 1.00 57.40  ? 176 TYR C CB  1 
ATOM 4635 C CG  . TYR C 3 176 ? 175.279 258.511 323.863 1.00 54.32  ? 176 TYR C CG  1 
ATOM 4636 C CD1 . TYR C 3 176 ? 175.645 258.638 322.535 1.00 58.63  ? 176 TYR C CD1 1 
ATOM 4637 C CD2 . TYR C 3 176 ? 175.951 257.583 324.638 1.00 58.12  ? 176 TYR C CD2 1 
ATOM 4638 C CE1 . TYR C 3 176 ? 176.643 257.860 321.994 1.00 58.76  ? 176 TYR C CE1 1 
ATOM 4639 C CE2 . TYR C 3 176 ? 176.950 256.803 324.106 1.00 59.73  ? 176 TYR C CE2 1 
ATOM 4640 C CZ  . TYR C 3 176 ? 177.291 256.945 322.784 1.00 56.08  ? 176 TYR C CZ  1 
ATOM 4641 O OH  . TYR C 3 176 ? 178.286 256.169 322.246 1.00 59.50  ? 176 TYR C OH  1 
ATOM 4642 N N   . ARG C 3 177 ? 171.435 258.486 326.282 1.00 51.86  ? 177 ARG C N   1 
ATOM 4643 C CA  . ARG C 3 177 ? 170.564 258.882 327.376 1.00 59.09  ? 177 ARG C CA  1 
ATOM 4644 C C   . ARG C 3 177 ? 171.399 259.083 328.631 1.00 59.01  ? 177 ARG C C   1 
ATOM 4645 O O   . ARG C 3 177 ? 172.224 258.232 328.974 1.00 68.35  ? 177 ARG C O   1 
ATOM 4646 C CB  . ARG C 3 177 ? 169.483 257.831 327.619 1.00 62.58  ? 177 ARG C CB  1 
ATOM 4647 C CG  . ARG C 3 177 ? 168.243 258.371 328.303 1.00 65.83  ? 177 ARG C CG  1 
ATOM 4648 C CD  . ARG C 3 177 ? 167.320 257.248 328.730 1.00 67.40  ? 177 ARG C CD  1 
ATOM 4649 N NE  . ARG C 3 177 ? 167.044 256.317 327.644 1.00 66.62  ? 177 ARG C NE  1 
ATOM 4650 C CZ  . ARG C 3 177 ? 166.387 255.175 327.788 1.00 71.19  ? 177 ARG C CZ  1 
ATOM 4651 N NH1 . ARG C 3 177 ? 165.919 254.791 328.964 1.00 69.07  ? 177 ARG C NH1 1 
ATOM 4652 N NH2 . ARG C 3 177 ? 166.197 254.398 326.727 1.00 72.37  ? 177 ARG C NH2 1 
ATOM 4653 N N   . LEU C 3 178 ? 171.185 260.205 329.309 1.00 60.63  ? 178 LEU C N   1 
ATOM 4654 C CA  . LEU C 3 178 ? 171.929 260.497 330.523 1.00 60.33  ? 178 LEU C CA  1 
ATOM 4655 C C   . LEU C 3 178 ? 171.778 259.349 331.510 1.00 62.10  ? 178 LEU C C   1 
ATOM 4656 O O   . LEU C 3 178 ? 170.699 258.771 331.653 1.00 56.08  ? 178 LEU C O   1 
ATOM 4657 C CB  . LEU C 3 178 ? 171.426 261.800 331.143 1.00 59.44  ? 178 LEU C CB  1 
ATOM 4658 C CG  . LEU C 3 178 ? 172.470 262.671 331.837 1.00 61.81  ? 178 LEU C CG  1 
ATOM 4659 C CD1 . LEU C 3 178 ? 173.306 263.414 330.814 1.00 63.80  ? 178 LEU C CD1 1 
ATOM 4660 C CD2 . LEU C 3 178 ? 171.804 263.644 332.789 1.00 62.35  ? 178 LEU C CD2 1 
ATOM 4661 N N   . THR C 3 179 ? 172.874 259.008 332.190 1.00 64.33  ? 179 THR C N   1 
ATOM 4662 C CA  . THR C 3 179 ? 172.841 257.874 333.108 1.00 59.85  ? 179 THR C CA  1 
ATOM 4663 C C   . THR C 3 179 ? 171.983 258.183 334.326 1.00 62.57  ? 179 THR C C   1 
ATOM 4664 O O   . THR C 3 179 ? 170.961 257.530 334.560 1.00 71.59  ? 179 THR C O   1 
ATOM 4665 C CB  . THR C 3 179 ? 174.259 257.493 333.537 1.00 55.34  ? 179 THR C CB  1 
ATOM 4666 O OG1 . THR C 3 179 ? 174.936 258.648 334.045 1.00 60.14  ? 179 THR C OG1 1 
ATOM 4667 C CG2 . THR C 3 179 ? 175.038 256.917 332.371 1.00 54.52  ? 179 THR C CG2 1 
ATOM 4668 N N   . ILE C 3 180 ? 172.373 259.186 335.110 1.00 65.68  ? 180 ILE C N   1 
ATOM 4669 C CA  . ILE C 3 180 ? 171.646 259.509 336.332 1.00 66.04  ? 180 ILE C CA  1 
ATOM 4670 C C   . ILE C 3 180 ? 170.939 260.849 336.181 1.00 69.34  ? 180 ILE C C   1 
ATOM 4671 O O   . ILE C 3 180 ? 171.506 261.906 336.475 1.00 71.92  ? 180 ILE C O   1 
ATOM 4672 C CB  . ILE C 3 180 ? 172.581 259.514 337.554 1.00 66.90  ? 180 ILE C CB  1 
ATOM 4673 C CG1 . ILE C 3 180 ? 173.829 260.357 337.291 1.00 71.45  ? 180 ILE C CG1 1 
ATOM 4674 C CG2 . ILE C 3 180 ? 172.991 258.097 337.900 1.00 65.07  ? 180 ILE C CG2 1 
ATOM 4675 C CD1 . ILE C 3 180 ? 174.596 260.706 338.548 1.00 70.56  ? 180 ILE C CD1 1 
ATOM 4676 N N   . ASP C 3 181 ? 169.687 260.808 335.733 1.00 88.28  ? 181 ASP C N   1 
ATOM 4677 C CA  . ASP C 3 181 ? 168.821 261.979 335.699 1.00 89.80  ? 181 ASP C CA  1 
ATOM 4678 C C   . ASP C 3 181 ? 167.517 261.612 336.385 1.00 91.10  ? 181 ASP C C   1 
ATOM 4679 O O   . ASP C 3 181 ? 166.824 260.687 335.950 1.00 93.83  ? 181 ASP C O   1 
ATOM 4680 C CB  . ASP C 3 181 ? 168.571 262.451 334.263 1.00 88.93  ? 181 ASP C CB  1 
ATOM 4681 C CG  . ASP C 3 181 ? 168.168 261.321 333.339 1.00 93.10  ? 181 ASP C CG  1 
ATOM 4682 O OD1 . ASP C 3 181 ? 168.096 260.166 333.806 1.00 94.54  ? 181 ASP C OD1 1 
ATOM 4683 O OD2 . ASP C 3 181 ? 167.927 261.588 332.142 1.00 89.85  ? 181 ASP C OD2 1 
ATOM 4684 N N   . ASP C 3 182 ? 167.186 262.330 337.457 1.00 102.41 ? 182 ASP C N   1 
ATOM 4685 C CA  . ASP C 3 182 ? 165.994 262.017 338.232 1.00 105.37 ? 182 ASP C CA  1 
ATOM 4686 C C   . ASP C 3 182 ? 164.710 262.461 337.545 1.00 105.95 ? 182 ASP C C   1 
ATOM 4687 O O   . ASP C 3 182 ? 163.623 262.096 338.006 1.00 107.28 ? 182 ASP C O   1 
ATOM 4688 C CB  . ASP C 3 182 ? 166.089 262.665 339.615 1.00 106.14 ? 182 ASP C CB  1 
ATOM 4689 C CG  . ASP C 3 182 ? 165.015 262.174 340.562 1.00 109.01 ? 182 ASP C CG  1 
ATOM 4690 O OD1 . ASP C 3 182 ? 164.982 260.957 340.842 1.00 103.60 ? 182 ASP C OD1 1 
ATOM 4691 O OD2 . ASP C 3 182 ? 164.206 263.004 341.029 1.00 109.85 ? 182 ASP C OD2 1 
ATOM 4692 N N   . SER C 3 183 ? 164.805 263.234 336.462 1.00 99.26  ? 183 SER C N   1 
ATOM 4693 C CA  . SER C 3 183 ? 163.603 263.658 335.754 1.00 103.72 ? 183 SER C CA  1 
ATOM 4694 C C   . SER C 3 183 ? 162.995 262.510 334.960 1.00 105.05 ? 183 SER C C   1 
ATOM 4695 O O   . SER C 3 183 ? 161.769 262.355 334.921 1.00 102.94 ? 183 SER C O   1 
ATOM 4696 C CB  . SER C 3 183 ? 163.926 264.831 334.831 1.00 103.04 ? 183 SER C CB  1 
ATOM 4697 O OG  . SER C 3 183 ? 162.775 265.245 334.114 1.00 103.19 ? 183 SER C OG  1 
ATOM 4698 N N   . PHE C 3 184 ? 163.831 261.696 334.321 1.00 93.27  ? 184 PHE C N   1 
ATOM 4699 C CA  . PHE C 3 184 ? 163.365 260.615 333.456 1.00 92.54  ? 184 PHE C CA  1 
ATOM 4700 C C   . PHE C 3 184 ? 163.219 259.353 334.295 1.00 92.09  ? 184 PHE C C   1 
ATOM 4701 O O   . PHE C 3 184 ? 164.190 258.628 334.523 1.00 88.44  ? 184 PHE C O   1 
ATOM 4702 C CB  . PHE C 3 184 ? 164.330 260.408 332.297 1.00 92.42  ? 184 PHE C CB  1 
ATOM 4703 C CG  . PHE C 3 184 ? 163.936 259.298 331.374 1.00 91.95  ? 184 PHE C CG  1 
ATOM 4704 C CD1 . PHE C 3 184 ? 162.995 259.507 330.383 1.00 90.93  ? 184 PHE C CD1 1 
ATOM 4705 C CD2 . PHE C 3 184 ? 164.511 258.048 331.491 1.00 89.19  ? 184 PHE C CD2 1 
ATOM 4706 C CE1 . PHE C 3 184 ? 162.633 258.487 329.530 1.00 87.40  ? 184 PHE C CE1 1 
ATOM 4707 C CE2 . PHE C 3 184 ? 164.153 257.028 330.640 1.00 88.54  ? 184 PHE C CE2 1 
ATOM 4708 C CZ  . PHE C 3 184 ? 163.213 257.248 329.659 1.00 87.20  ? 184 PHE C CZ  1 
ATOM 4709 N N   . THR C 3 185 ? 161.995 259.085 334.752 1.00 101.34 ? 185 THR C N   1 
ATOM 4710 C CA  . THR C 3 185 ? 161.695 257.923 335.579 1.00 102.01 ? 185 THR C CA  1 
ATOM 4711 C C   . THR C 3 185 ? 160.777 256.932 334.870 1.00 100.05 ? 185 THR C C   1 
ATOM 4712 O O   . THR C 3 185 ? 160.150 256.096 335.526 1.00 98.81  ? 185 THR C O   1 
ATOM 4713 C CB  . THR C 3 185 ? 161.069 258.365 336.901 1.00 102.84 ? 185 THR C CB  1 
ATOM 4714 O OG1 . THR C 3 185 ? 159.818 259.016 336.647 1.00 97.82  ? 185 THR C OG1 1 
ATOM 4715 C CG2 . THR C 3 185 ? 161.995 259.321 337.635 1.00 101.10 ? 185 THR C CG2 1 
ATOM 4716 N N   . GLU C 3 186 ? 160.687 257.011 333.543 1.00 96.67  ? 186 GLU C N   1 
ATOM 4717 C CA  . GLU C 3 186 ? 159.846 256.107 332.769 1.00 97.53  ? 186 GLU C CA  1 
ATOM 4718 C C   . GLU C 3 186 ? 160.685 255.329 331.766 1.00 95.48  ? 186 GLU C C   1 
ATOM 4719 O O   . GLU C 3 186 ? 160.306 255.203 330.597 1.00 92.01  ? 186 GLU C O   1 
ATOM 4720 C CB  . GLU C 3 186 ? 158.745 256.884 332.045 1.00 95.04  ? 186 GLU C CB  1 
ATOM 4721 C CG  . GLU C 3 186 ? 157.802 257.645 332.963 1.00 96.13  ? 186 GLU C CG  1 
ATOM 4722 C CD  . GLU C 3 186 ? 157.023 256.734 333.891 1.00 96.75  ? 186 GLU C CD  1 
ATOM 4723 O OE1 . GLU C 3 186 ? 157.645 256.108 334.773 1.00 97.74  ? 186 GLU C OE1 1 
ATOM 4724 O OE2 . GLU C 3 186 ? 155.788 256.640 333.733 1.00 94.77  ? 186 GLU C OE2 1 
ATOM 4725 N N   . GLY C 3 187 ? 161.822 254.803 332.212 1.00 81.71  ? 187 GLY C N   1 
ATOM 4726 C CA  . GLY C 3 187 ? 162.734 254.103 331.330 1.00 79.51  ? 187 GLY C CA  1 
ATOM 4727 C C   . GLY C 3 187 ? 162.298 252.715 330.930 1.00 79.19  ? 187 GLY C C   1 
ATOM 4728 O O   . GLY C 3 187 ? 163.037 252.036 330.210 1.00 84.45  ? 187 GLY C O   1 
ATOM 4729 N N   . GLY C 3 188 ? 161.129 252.274 331.368 1.00 64.31  ? 188 GLY C N   1 
ATOM 4730 C CA  . GLY C 3 188 ? 160.653 250.943 331.067 1.00 62.42  ? 188 GLY C CA  1 
ATOM 4731 C C   . GLY C 3 188 ? 160.855 249.995 332.235 1.00 64.72  ? 188 GLY C C   1 
ATOM 4732 O O   . GLY C 3 188 ? 161.722 250.184 333.090 1.00 68.43  ? 188 GLY C O   1 
ATOM 4733 N N   . TYR C 3 189 ? 160.031 248.954 332.267 1.00 69.88  ? 189 TYR C N   1 
ATOM 4734 C CA  . TYR C 3 189 ? 160.041 247.995 333.359 1.00 66.73  ? 189 TYR C CA  1 
ATOM 4735 C C   . TYR C 3 189 ? 160.078 246.584 332.801 1.00 68.06  ? 189 TYR C C   1 
ATOM 4736 O O   . TYR C 3 189 ? 159.605 246.328 331.694 1.00 67.76  ? 189 TYR C O   1 
ATOM 4737 C CB  . TYR C 3 189 ? 158.810 248.151 334.253 1.00 67.44  ? 189 TYR C CB  1 
ATOM 4738 C CG  . TYR C 3 189 ? 158.747 249.467 334.980 1.00 63.76  ? 189 TYR C CG  1 
ATOM 4739 C CD1 . TYR C 3 189 ? 158.442 250.636 334.307 1.00 66.43  ? 189 TYR C CD1 1 
ATOM 4740 C CD2 . TYR C 3 189 ? 158.984 249.538 336.343 1.00 67.41  ? 189 TYR C CD2 1 
ATOM 4741 C CE1 . TYR C 3 189 ? 158.382 251.841 334.966 1.00 73.18  ? 189 TYR C CE1 1 
ATOM 4742 C CE2 . TYR C 3 189 ? 158.926 250.739 337.012 1.00 73.64  ? 189 TYR C CE2 1 
ATOM 4743 C CZ  . TYR C 3 189 ? 158.624 251.888 336.319 1.00 76.00  ? 189 TYR C CZ  1 
ATOM 4744 O OH  . TYR C 3 189 ? 158.564 253.092 336.981 1.00 76.01  ? 189 TYR C OH  1 
ATOM 4745 N N   . ILE C 3 190 ? 160.653 245.671 333.576 1.00 61.20  ? 190 ILE C N   1 
ATOM 4746 C CA  . ILE C 3 190 ? 160.567 244.245 333.294 1.00 58.64  ? 190 ILE C CA  1 
ATOM 4747 C C   . ILE C 3 190 ? 160.021 243.572 334.543 1.00 62.11  ? 190 ILE C C   1 
ATOM 4748 O O   . ILE C 3 190 ? 160.570 243.744 335.636 1.00 65.49  ? 190 ILE C O   1 
ATOM 4749 C CB  . ILE C 3 190 ? 161.922 243.646 332.883 1.00 56.59  ? 190 ILE C CB  1 
ATOM 4750 C CG1 . ILE C 3 190 ? 161.734 242.217 332.385 1.00 58.55  ? 190 ILE C CG1 1 
ATOM 4751 C CG2 . ILE C 3 190 ? 162.894 243.669 334.038 1.00 61.44  ? 190 ILE C CG2 1 
ATOM 4752 C CD1 . ILE C 3 190 ? 162.924 241.677 331.643 1.00 61.97  ? 190 ILE C CD1 1 
ATOM 4753 N N   . SER C 3 191 ? 158.933 242.828 334.389 1.00 67.32  ? 191 SER C N   1 
ATOM 4754 C CA  . SER C 3 191 ? 158.219 242.258 335.518 1.00 67.53  ? 191 SER C CA  1 
ATOM 4755 C C   . SER C 3 191 ? 157.999 240.772 335.292 1.00 63.04  ? 191 SER C C   1 
ATOM 4756 O O   . SER C 3 191 ? 157.987 240.289 334.158 1.00 69.74  ? 191 SER C O   1 
ATOM 4757 C CB  . SER C 3 191 ? 156.874 242.959 335.739 1.00 69.02  ? 191 SER C CB  1 
ATOM 4758 O OG  . SER C 3 191 ? 157.057 244.338 336.001 1.00 66.18  ? 191 SER C OG  1 
ATOM 4759 N N   . VAL C 3 192 ? 157.831 240.047 336.395 1.00 57.08  ? 192 VAL C N   1 
ATOM 4760 C CA  . VAL C 3 192 ? 157.587 238.610 336.363 1.00 60.43  ? 192 VAL C CA  1 
ATOM 4761 C C   . VAL C 3 192 ? 156.275 238.326 337.080 1.00 68.27  ? 192 VAL C C   1 
ATOM 4762 O O   . VAL C 3 192 ? 156.076 238.767 338.218 1.00 68.95  ? 192 VAL C O   1 
ATOM 4763 C CB  . VAL C 3 192 ? 158.744 237.822 337.001 1.00 56.44  ? 192 VAL C CB  1 
ATOM 4764 C CG1 . VAL C 3 192 ? 158.466 236.336 336.946 1.00 52.30  ? 192 VAL C CG1 1 
ATOM 4765 C CG2 . VAL C 3 192 ? 160.044 238.139 336.294 1.00 62.75  ? 192 VAL C CG2 1 
ATOM 4766 N N   . PHE C 3 193 ? 155.391 237.581 336.417 1.00 70.32  ? 193 PHE C N   1 
ATOM 4767 C CA  . PHE C 3 193 ? 154.063 237.274 336.925 1.00 62.85  ? 193 PHE C CA  1 
ATOM 4768 C C   . PHE C 3 193 ? 153.839 235.770 336.971 1.00 63.19  ? 193 PHE C C   1 
ATOM 4769 O O   . PHE C 3 193 ? 154.363 235.020 336.144 1.00 64.59  ? 193 PHE C O   1 
ATOM 4770 C CB  . PHE C 3 193 ? 152.972 237.900 336.056 1.00 65.03  ? 193 PHE C CB  1 
ATOM 4771 C CG  . PHE C 3 193 ? 152.927 239.392 336.117 1.00 66.17  ? 193 PHE C CG  1 
ATOM 4772 C CD1 . PHE C 3 193 ? 152.293 240.034 337.161 1.00 69.90  ? 193 PHE C CD1 1 
ATOM 4773 C CD2 . PHE C 3 193 ? 153.505 240.152 335.122 1.00 66.39  ? 193 PHE C CD2 1 
ATOM 4774 C CE1 . PHE C 3 193 ? 152.248 241.403 337.217 1.00 71.34  ? 193 PHE C CE1 1 
ATOM 4775 C CE2 . PHE C 3 193 ? 153.463 241.521 335.175 1.00 69.54  ? 193 PHE C CE2 1 
ATOM 4776 C CZ  . PHE C 3 193 ? 152.832 242.148 336.222 1.00 70.91  ? 193 PHE C CZ  1 
ATOM 4777 N N   . TYR C 3 194 ? 153.034 235.344 337.939 1.00 67.32  ? 194 TYR C N   1 
ATOM 4778 C CA  . TYR C 3 194 ? 152.614 233.951 338.058 1.00 68.48  ? 194 TYR C CA  1 
ATOM 4779 C C   . TYR C 3 194 ? 151.566 233.653 336.997 1.00 71.08  ? 194 TYR C C   1 
ATOM 4780 O O   . TYR C 3 194 ? 150.376 233.892 337.203 1.00 75.81  ? 194 TYR C O   1 
ATOM 4781 C CB  . TYR C 3 194 ? 152.038 233.688 339.444 1.00 72.91  ? 194 TYR C CB  1 
ATOM 4782 C CG  . TYR C 3 194 ? 153.028 233.293 340.510 1.00 70.29  ? 194 TYR C CG  1 
ATOM 4783 C CD1 . TYR C 3 194 ? 153.999 232.334 340.273 1.00 66.36  ? 194 TYR C CD1 1 
ATOM 4784 C CD2 . TYR C 3 194 ? 152.971 233.869 341.769 1.00 73.37  ? 194 TYR C CD2 1 
ATOM 4785 C CE1 . TYR C 3 194 ? 154.890 231.971 341.258 1.00 74.60  ? 194 TYR C CE1 1 
ATOM 4786 C CE2 . TYR C 3 194 ? 153.857 233.514 342.756 1.00 72.21  ? 194 TYR C CE2 1 
ATOM 4787 C CZ  . TYR C 3 194 ? 154.813 232.567 342.498 1.00 74.68  ? 194 TYR C CZ  1 
ATOM 4788 O OH  . TYR C 3 194 ? 155.693 232.215 343.491 1.00 76.68  ? 194 TYR C OH  1 
ATOM 4789 N N   . GLN C 3 195 ? 151.993 233.124 335.852 1.00 63.66  ? 195 GLN C N   1 
ATOM 4790 C CA  . GLN C 3 195 ? 151.020 232.671 334.864 1.00 63.69  ? 195 GLN C CA  1 
ATOM 4791 C C   . GLN C 3 195 ? 150.160 231.553 335.436 1.00 68.07  ? 195 GLN C C   1 
ATOM 4792 O O   . GLN C 3 195 ? 148.931 231.573 335.316 1.00 71.83  ? 195 GLN C O   1 
ATOM 4793 C CB  . GLN C 3 195 ? 151.735 232.209 333.597 1.00 61.82  ? 195 GLN C CB  1 
ATOM 4794 C CG  . GLN C 3 195 ? 150.820 231.606 332.546 1.00 64.31  ? 195 GLN C CG  1 
ATOM 4795 C CD  . GLN C 3 195 ? 149.764 232.569 332.062 1.00 66.65  ? 195 GLN C CD  1 
ATOM 4796 O OE1 . GLN C 3 195 ? 149.890 233.150 330.987 1.00 72.43  ? 195 GLN C OE1 1 
ATOM 4797 N NE2 . GLN C 3 195 ? 148.709 232.738 332.847 1.00 63.73  ? 195 GLN C NE2 1 
ATOM 4798 N N   . THR C 3 196 ? 150.794 230.569 336.069 1.00 68.72  ? 196 THR C N   1 
ATOM 4799 C CA  . THR C 3 196 ? 150.100 229.474 336.729 1.00 64.45  ? 196 THR C CA  1 
ATOM 4800 C C   . THR C 3 196 ? 150.850 229.120 338.000 1.00 66.00  ? 196 THR C C   1 
ATOM 4801 O O   . THR C 3 196 ? 152.082 229.057 337.998 1.00 74.58  ? 196 THR C O   1 
ATOM 4802 C CB  . THR C 3 196 ? 150.016 228.227 335.848 1.00 64.70  ? 196 THR C CB  1 
ATOM 4803 O OG1 . THR C 3 196 ? 151.249 227.504 335.932 1.00 59.28  ? 196 THR C OG1 1 
ATOM 4804 C CG2 . THR C 3 196 ? 149.761 228.597 334.407 1.00 69.40  ? 196 THR C CG2 1 
ATOM 4805 N N   . ARG C 3 197 ? 150.110 228.872 339.076 1.00 75.14  ? 197 ARG C N   1 
ATOM 4806 C CA  . ARG C 3 197 ? 150.737 228.467 340.325 1.00 80.72  ? 197 ARG C CA  1 
ATOM 4807 C C   . ARG C 3 197 ? 151.647 227.274 340.073 1.00 79.90  ? 197 ARG C C   1 
ATOM 4808 O O   . ARG C 3 197 ? 151.487 226.566 339.075 1.00 81.99  ? 197 ARG C O   1 
ATOM 4809 C CB  . ARG C 3 197 ? 149.683 228.129 341.379 1.00 78.91  ? 197 ARG C CB  1 
ATOM 4810 C CG  . ARG C 3 197 ? 148.776 226.975 341.002 1.00 79.63  ? 197 ARG C CG  1 
ATOM 4811 C CD  . ARG C 3 197 ? 147.797 226.664 342.117 1.00 82.11  ? 197 ARG C CD  1 
ATOM 4812 N NE  . ARG C 3 197 ? 146.894 227.777 342.381 1.00 83.15  ? 197 ARG C NE  1 
ATOM 4813 C CZ  . ARG C 3 197 ? 146.008 227.806 343.367 1.00 83.41  ? 197 ARG C CZ  1 
ATOM 4814 N NH1 . ARG C 3 197 ? 145.885 226.800 344.217 1.00 80.08  ? 197 ARG C NH1 1 
ATOM 4815 N NH2 . ARG C 3 197 ? 145.226 228.873 343.505 1.00 86.15  ? 197 ARG C NH2 1 
ATOM 4816 N N   . ILE C 3 198 ? 152.608 227.052 340.958 1.00 70.05  ? 198 ILE C N   1 
ATOM 4817 C CA  . ILE C 3 198 ? 153.575 225.977 340.778 1.00 70.08  ? 198 ILE C CA  1 
ATOM 4818 C C   . ILE C 3 198 ? 152.957 224.663 341.230 1.00 74.42  ? 198 ILE C C   1 
ATOM 4819 O O   . ILE C 3 198 ? 152.246 224.604 342.240 1.00 77.07  ? 198 ILE C O   1 
ATOM 4820 C CB  . ILE C 3 198 ? 154.866 226.278 341.558 1.00 70.93  ? 198 ILE C CB  1 
ATOM 4821 C CG1 . ILE C 3 198 ? 155.386 227.679 341.219 1.00 69.24  ? 198 ILE C CG1 1 
ATOM 4822 C CG2 . ILE C 3 198 ? 155.914 225.212 341.269 1.00 71.08  ? 198 ILE C CG2 1 
ATOM 4823 C CD1 . ILE C 3 198 ? 155.869 227.840 339.800 1.00 69.83  ? 198 ILE C CD1 1 
ATOM 4824 N N   . VAL C 3 199 ? 153.235 223.599 340.484 1.00 69.08  ? 199 VAL C N   1 
ATOM 4825 C CA  . VAL C 3 199 ? 152.755 222.258 340.797 1.00 61.19  ? 199 VAL C CA  1 
ATOM 4826 C C   . VAL C 3 199 ? 153.970 221.372 341.021 1.00 64.13  ? 199 VAL C C   1 
ATOM 4827 O O   . VAL C 3 199 ? 154.826 221.250 340.136 1.00 60.37  ? 199 VAL C O   1 
ATOM 4828 C CB  . VAL C 3 199 ? 151.860 221.695 339.682 1.00 59.30  ? 199 VAL C CB  1 
ATOM 4829 C CG1 . VAL C 3 199 ? 152.388 222.101 338.322 1.00 63.41  ? 199 VAL C CG1 1 
ATOM 4830 C CG2 . VAL C 3 199 ? 151.781 220.186 339.774 1.00 64.61  ? 199 VAL C CG2 1 
ATOM 4831 N N   . VAL C 3 200 ? 154.041 220.754 342.195 1.00 66.28  ? 200 VAL C N   1 
ATOM 4832 C CA  . VAL C 3 200 ? 155.160 219.891 342.557 1.00 61.83  ? 200 VAL C CA  1 
ATOM 4833 C C   . VAL C 3 200 ? 154.607 218.565 343.064 1.00 61.90  ? 200 VAL C C   1 
ATOM 4834 O O   . VAL C 3 200 ? 153.533 218.544 343.681 1.00 66.69  ? 200 VAL C O   1 
ATOM 4835 C CB  . VAL C 3 200 ? 156.055 220.551 343.617 1.00 63.75  ? 200 VAL C CB  1 
ATOM 4836 C CG1 . VAL C 3 200 ? 156.703 221.799 343.057 1.00 63.16  ? 200 VAL C CG1 1 
ATOM 4837 C CG2 . VAL C 3 200 ? 155.251 220.878 344.867 1.00 63.44  ? 200 VAL C CG2 1 
ATOM 4838 N N   . PRO C 3 201 ? 155.289 217.447 342.840 1.00 54.64  ? 201 PRO C N   1 
ATOM 4839 C CA  . PRO C 3 201 ? 154.790 216.161 343.324 1.00 53.32  ? 201 PRO C CA  1 
ATOM 4840 C C   . PRO C 3 201 ? 155.320 215.803 344.705 1.00 57.71  ? 201 PRO C C   1 
ATOM 4841 O O   . PRO C 3 201 ? 156.350 216.300 345.162 1.00 64.32  ? 201 PRO C O   1 
ATOM 4842 C CB  . PRO C 3 201 ? 155.322 215.180 342.275 1.00 58.51  ? 201 PRO C CB  1 
ATOM 4843 C CG  . PRO C 3 201 ? 156.605 215.775 341.862 1.00 55.59  ? 201 PRO C CG  1 
ATOM 4844 C CD  . PRO C 3 201 ? 156.446 217.271 341.946 1.00 57.11  ? 201 PRO C CD  1 
ATOM 4845 N N   . LEU C 3 202 ? 154.589 214.912 345.356 1.00 58.86  ? 202 LEU C N   1 
ATOM 4846 C CA  . LEU C 3 202 ? 154.981 214.357 346.651 1.00 57.62  ? 202 LEU C CA  1 
ATOM 4847 C C   . LEU C 3 202 ? 155.307 215.507 347.602 1.00 65.28  ? 202 LEU C C   1 
ATOM 4848 O O   . LEU C 3 202 ? 154.699 216.579 347.532 1.00 69.42  ? 202 LEU C O   1 
ATOM 4849 C CB  . LEU C 3 202 ? 156.107 213.372 346.437 1.00 54.67  ? 202 LEU C CB  1 
ATOM 4850 C CG  . LEU C 3 202 ? 155.763 212.199 345.527 1.00 59.91  ? 202 LEU C CG  1 
ATOM 4851 C CD1 . LEU C 3 202 ? 157.029 211.490 345.134 1.00 64.40  ? 202 LEU C CD1 1 
ATOM 4852 C CD2 . LEU C 3 202 ? 154.810 211.246 346.223 1.00 56.87  ? 202 LEU C CD2 1 
ATOM 4853 N N   . SER C 3 203 ? 156.270 215.296 348.497 1.00 63.83  ? 203 SER C N   1 
ATOM 4854 C CA  . SER C 3 203 ? 156.629 216.271 349.512 1.00 60.43  ? 203 SER C CA  1 
ATOM 4855 C C   . SER C 3 203 ? 157.674 217.264 349.026 1.00 55.73  ? 203 SER C C   1 
ATOM 4856 O O   . SER C 3 203 ? 158.383 217.852 349.849 1.00 62.70  ? 203 SER C O   1 
ATOM 4857 C CB  . SER C 3 203 ? 157.138 215.555 350.762 1.00 63.21  ? 203 SER C CB  1 
ATOM 4858 O OG  . SER C 3 203 ? 156.314 214.448 351.078 1.00 67.79  ? 203 SER C OG  1 
ATOM 4859 N N   . THR C 3 204 ? 157.788 217.460 347.720 1.00 52.94  ? 204 THR C N   1 
ATOM 4860 C CA  . THR C 3 204 ? 158.769 218.396 347.200 1.00 61.61  ? 204 THR C CA  1 
ATOM 4861 C C   . THR C 3 204 ? 158.524 219.773 347.811 1.00 67.37  ? 204 THR C C   1 
ATOM 4862 O O   . THR C 3 204 ? 157.368 220.209 347.889 1.00 72.10  ? 204 THR C O   1 
ATOM 4863 C CB  . THR C 3 204 ? 158.684 218.467 345.678 1.00 60.01  ? 204 THR C CB  1 
ATOM 4864 O OG1 . THR C 3 204 ? 159.043 217.198 345.120 1.00 54.04  ? 204 THR C OG1 1 
ATOM 4865 C CG2 . THR C 3 204 ? 159.618 219.528 345.135 1.00 61.70  ? 204 THR C CG2 1 
ATOM 4866 N N   . PRO C 3 205 ? 159.561 220.478 348.262 1.00 64.52  ? 205 PRO C N   1 
ATOM 4867 C CA  . PRO C 3 205 ? 159.326 221.734 348.983 1.00 62.74  ? 205 PRO C CA  1 
ATOM 4868 C C   . PRO C 3 205 ? 158.581 222.744 348.127 1.00 68.84  ? 205 PRO C C   1 
ATOM 4869 O O   . PRO C 3 205 ? 158.825 222.872 346.926 1.00 70.71  ? 205 PRO C O   1 
ATOM 4870 C CB  . PRO C 3 205 ? 160.738 222.221 349.322 1.00 65.97  ? 205 PRO C CB  1 
ATOM 4871 C CG  . PRO C 3 205 ? 161.597 221.023 349.220 1.00 75.62  ? 205 PRO C CG  1 
ATOM 4872 C CD  . PRO C 3 205 ? 160.998 220.184 348.145 1.00 68.84  ? 205 PRO C CD  1 
ATOM 4873 N N   . ARG C 3 206 ? 157.665 223.471 348.767 1.00 78.78  ? 206 ARG C N   1 
ATOM 4874 C CA  . ARG C 3 206 ? 156.919 224.509 348.065 1.00 77.73  ? 206 ARG C CA  1 
ATOM 4875 C C   . ARG C 3 206 ? 157.815 225.692 347.720 1.00 79.47  ? 206 ARG C C   1 
ATOM 4876 O O   . ARG C 3 206 ? 157.813 226.173 346.582 1.00 80.81  ? 206 ARG C O   1 
ATOM 4877 C CB  . ARG C 3 206 ? 155.736 224.965 348.915 1.00 75.78  ? 206 ARG C CB  1 
ATOM 4878 C CG  . ARG C 3 206 ? 154.389 224.462 348.431 1.00 80.53  ? 206 ARG C CG  1 
ATOM 4879 C CD  . ARG C 3 206 ? 154.316 222.947 348.407 1.00 81.78  ? 206 ARG C CD  1 
ATOM 4880 N NE  . ARG C 3 206 ? 152.967 222.487 348.103 1.00 80.21  ? 206 ARG C NE  1 
ATOM 4881 C CZ  . ARG C 3 206 ? 152.650 221.239 347.790 1.00 79.03  ? 206 ARG C CZ  1 
ATOM 4882 N NH1 . ARG C 3 206 ? 153.570 220.291 347.709 1.00 74.96  ? 206 ARG C NH1 1 
ATOM 4883 N NH2 . ARG C 3 206 ? 151.379 220.934 347.550 1.00 79.05  ? 206 ARG C NH2 1 
ATOM 4884 N N   . GLU C 3 207 ? 158.585 226.175 348.690 1.00 81.67  ? 207 GLU C N   1 
ATOM 4885 C CA  . GLU C 3 207 ? 159.434 227.337 348.463 1.00 77.60  ? 207 GLU C CA  1 
ATOM 4886 C C   . GLU C 3 207 ? 160.507 227.018 347.431 1.00 71.38  ? 207 GLU C C   1 
ATOM 4887 O O   . GLU C 3 207 ? 161.138 225.960 347.479 1.00 76.48  ? 207 GLU C O   1 
ATOM 4888 C CB  . GLU C 3 207 ? 160.077 227.801 349.771 1.00 75.24  ? 207 GLU C CB  1 
ATOM 4889 C CG  . GLU C 3 207 ? 161.030 226.802 350.428 1.00 78.46  ? 207 GLU C CG  1 
ATOM 4890 C CD  . GLU C 3 207 ? 160.310 225.692 351.168 1.00 82.23  ? 207 GLU C CD  1 
ATOM 4891 O OE1 . GLU C 3 207 ? 159.065 225.736 351.242 1.00 86.27  ? 207 GLU C OE1 1 
ATOM 4892 O OE2 . GLU C 3 207 ? 160.988 224.774 351.674 1.00 80.07  ? 207 GLU C OE2 1 
ATOM 4893 N N   . MET C 3 208 ? 160.709 227.940 346.495 1.00 65.93  ? 208 MET C N   1 
ATOM 4894 C CA  . MET C 3 208 ? 161.715 227.803 345.454 1.00 69.83  ? 208 MET C CA  1 
ATOM 4895 C C   . MET C 3 208 ? 162.405 229.148 345.289 1.00 74.66  ? 208 MET C C   1 
ATOM 4896 O O   . MET C 3 208 ? 162.049 230.129 345.945 1.00 76.71  ? 208 MET C O   1 
ATOM 4897 C CB  . MET C 3 208 ? 161.086 227.330 344.143 1.00 63.63  ? 208 MET C CB  1 
ATOM 4898 C CG  . MET C 3 208 ? 160.151 226.153 344.324 1.00 67.43  ? 208 MET C CG  1 
ATOM 4899 S SD  . MET C 3 208 ? 159.423 225.577 342.789 1.00 83.80  ? 208 MET C SD  1 
ATOM 4900 C CE  . MET C 3 208 ? 158.638 227.078 342.218 1.00 73.10  ? 208 MET C CE  1 
ATOM 4901 N N   . ASP C 3 209 ? 163.400 229.199 344.408 1.00 75.57  ? 209 ASP C N   1 
ATOM 4902 C CA  . ASP C 3 209 ? 164.201 230.399 344.231 1.00 68.46  ? 209 ASP C CA  1 
ATOM 4903 C C   . ASP C 3 209 ? 164.359 230.726 342.756 1.00 64.51  ? 209 ASP C C   1 
ATOM 4904 O O   . ASP C 3 209 ? 164.431 229.837 341.903 1.00 72.60  ? 209 ASP C O   1 
ATOM 4905 C CB  . ASP C 3 209 ? 165.584 230.248 344.865 1.00 75.44  ? 209 ASP C CB  1 
ATOM 4906 C CG  . ASP C 3 209 ? 165.528 230.184 346.375 1.00 80.62  ? 209 ASP C CG  1 
ATOM 4907 O OD1 . ASP C 3 209 ? 164.420 230.286 346.938 1.00 78.77  ? 209 ASP C OD1 1 
ATOM 4908 O OD2 . ASP C 3 209 ? 166.594 230.030 347.000 1.00 81.73  ? 209 ASP C OD2 1 
ATOM 4909 N N   . ILE C 3 210 ? 164.420 232.019 342.470 1.00 58.64  ? 210 ILE C N   1 
ATOM 4910 C CA  . ILE C 3 210 ? 164.695 232.517 341.131 1.00 62.82  ? 210 ILE C CA  1 
ATOM 4911 C C   . ILE C 3 210 ? 165.792 233.564 341.232 1.00 65.46  ? 210 ILE C C   1 
ATOM 4912 O O   . ILE C 3 210 ? 165.766 234.424 342.122 1.00 66.25  ? 210 ILE C O   1 
ATOM 4913 C CB  . ILE C 3 210 ? 163.432 233.100 340.469 1.00 62.95  ? 210 ILE C CB  1 
ATOM 4914 C CG1 . ILE C 3 210 ? 163.691 233.374 338.990 1.00 61.74  ? 210 ILE C CG1 1 
ATOM 4915 C CG2 . ILE C 3 210 ? 163.009 234.368 341.175 1.00 62.47  ? 210 ILE C CG2 1 
ATOM 4916 C CD1 . ILE C 3 210 ? 162.461 233.784 338.225 1.00 59.62  ? 210 ILE C CD1 1 
ATOM 4917 N N   . LEU C 3 211 ? 166.763 233.475 340.327 1.00 61.65  ? 211 LEU C N   1 
ATOM 4918 C CA  . LEU C 3 211 ? 167.913 234.361 340.278 1.00 62.69  ? 211 LEU C CA  1 
ATOM 4919 C C   . LEU C 3 211 ? 167.870 235.185 339.002 1.00 63.83  ? 211 LEU C C   1 
ATOM 4920 O O   . LEU C 3 211 ? 167.400 234.720 337.963 1.00 71.51  ? 211 LEU C O   1 
ATOM 4921 C CB  . LEU C 3 211 ? 169.219 233.568 340.316 1.00 60.83  ? 211 LEU C CB  1 
ATOM 4922 C CG  . LEU C 3 211 ? 169.330 232.492 341.388 1.00 57.96  ? 211 LEU C CG  1 
ATOM 4923 C CD1 . LEU C 3 211 ? 170.702 231.862 341.342 1.00 62.17  ? 211 LEU C CD1 1 
ATOM 4924 C CD2 . LEU C 3 211 ? 169.060 233.083 342.746 1.00 60.08  ? 211 LEU C CD2 1 
ATOM 4925 N N   . GLY C 3 212 ? 168.373 236.406 339.082 1.00 45.45  ? 212 GLY C N   1 
ATOM 4926 C CA  . GLY C 3 212 ? 168.407 237.307 337.941 1.00 53.33  ? 212 GLY C CA  1 
ATOM 4927 C C   . GLY C 3 212 ? 169.828 237.709 337.604 1.00 50.28  ? 212 GLY C C   1 
ATOM 4928 O O   . GLY C 3 212 ? 170.652 237.900 338.498 1.00 68.76  ? 212 GLY C O   1 
ATOM 4929 N N   . PHE C 3 213 ? 170.106 237.839 336.310 1.00 47.73  ? 213 PHE C N   1 
ATOM 4930 C CA  . PHE C 3 213 ? 171.403 238.287 335.827 1.00 57.20  ? 213 PHE C CA  1 
ATOM 4931 C C   . PHE C 3 213 ? 171.193 239.371 334.786 1.00 55.82  ? 213 PHE C C   1 
ATOM 4932 O O   . PHE C 3 213 ? 170.429 239.179 333.838 1.00 69.76  ? 213 PHE C O   1 
ATOM 4933 C CB  . PHE C 3 213 ? 172.202 237.132 335.218 1.00 57.93  ? 213 PHE C CB  1 
ATOM 4934 C CG  . PHE C 3 213 ? 172.463 236.009 336.173 1.00 53.95  ? 213 PHE C CG  1 
ATOM 4935 C CD1 . PHE C 3 213 ? 173.232 236.210 337.301 1.00 56.92  ? 213 PHE C CD1 1 
ATOM 4936 C CD2 . PHE C 3 213 ? 171.952 234.751 335.936 1.00 51.69  ? 213 PHE C CD2 1 
ATOM 4937 C CE1 . PHE C 3 213 ? 173.474 235.185 338.177 1.00 52.43  ? 213 PHE C CE1 1 
ATOM 4938 C CE2 . PHE C 3 213 ? 172.194 233.722 336.810 1.00 57.08  ? 213 PHE C CE2 1 
ATOM 4939 C CZ  . PHE C 3 213 ? 172.956 233.940 337.933 1.00 57.88  ? 213 PHE C CZ  1 
ATOM 4940 N N   . VAL C 3 214 ? 171.881 240.496 334.950 1.00 52.27  ? 214 VAL C N   1 
ATOM 4941 C CA  . VAL C 3 214 ? 171.761 241.636 334.050 1.00 51.33  ? 214 VAL C CA  1 
ATOM 4942 C C   . VAL C 3 214 ? 173.105 241.861 333.382 1.00 57.14  ? 214 VAL C C   1 
ATOM 4943 O O   . VAL C 3 214 ? 174.123 242.021 334.064 1.00 64.73  ? 214 VAL C O   1 
ATOM 4944 C CB  . VAL C 3 214 ? 171.310 242.905 334.792 1.00 53.60  ? 214 VAL C CB  1 
ATOM 4945 C CG1 . VAL C 3 214 ? 172.300 243.268 335.880 1.00 62.47  ? 214 VAL C CG1 1 
ATOM 4946 C CG2 . VAL C 3 214 ? 171.155 244.052 333.816 1.00 58.08  ? 214 VAL C CG2 1 
ATOM 4947 N N   . SER C 3 215 ? 173.108 241.884 332.054 1.00 50.52  ? 215 SER C N   1 
ATOM 4948 C CA  . SER C 3 215 ? 174.335 242.072 331.300 1.00 47.37  ? 215 SER C CA  1 
ATOM 4949 C C   . SER C 3 215 ? 174.088 243.075 330.188 1.00 48.39  ? 215 SER C C   1 
ATOM 4950 O O   . SER C 3 215 ? 172.949 243.329 329.796 1.00 65.91  ? 215 SER C O   1 
ATOM 4951 C CB  . SER C 3 215 ? 174.839 240.757 330.705 1.00 55.41  ? 215 SER C CB  1 
ATOM 4952 O OG  . SER C 3 215 ? 174.084 240.404 329.562 1.00 57.65  ? 215 SER C OG  1 
ATOM 4953 N N   . ALA C 3 216 ? 175.168 243.665 329.697 1.00 48.72  ? 216 ALA C N   1 
ATOM 4954 C CA  . ALA C 3 216 ? 175.073 244.500 328.516 1.00 50.46  ? 216 ALA C CA  1 
ATOM 4955 C C   . ALA C 3 216 ? 175.041 243.629 327.267 1.00 53.29  ? 216 ALA C C   1 
ATOM 4956 O O   . ALA C 3 216 ? 175.463 242.470 327.275 1.00 60.49  ? 216 ALA C O   1 
ATOM 4957 C CB  . ALA C 3 216 ? 176.245 245.475 328.448 1.00 58.23  ? 216 ALA C CB  1 
ATOM 4958 N N   . CYS C 3 217 ? 174.523 244.194 326.186 1.00 61.21  ? 217 CYS C N   1 
ATOM 4959 C CA  . CYS C 3 217 ? 174.503 243.517 324.903 1.00 66.84  ? 217 CYS C CA  1 
ATOM 4960 C C   . CYS C 3 217 ? 175.710 243.973 324.089 1.00 65.52  ? 217 CYS C C   1 
ATOM 4961 O O   . CYS C 3 217 ? 176.452 244.874 324.483 1.00 67.22  ? 217 CYS C O   1 
ATOM 4962 C CB  . CYS C 3 217 ? 173.184 243.786 324.178 1.00 72.41  ? 217 CYS C CB  1 
ATOM 4963 S SG  . CYS C 3 217 ? 172.748 242.564 322.915 1.00 87.02  ? 217 CYS C SG  1 
ATOM 4964 N N   . ASN C 3 218 ? 175.911 243.340 322.935 1.00 70.65  ? 218 ASN C N   1 
ATOM 4965 C CA  . ASN C 3 218 ? 177.110 243.592 322.147 1.00 71.91  ? 218 ASN C CA  1 
ATOM 4966 C C   . ASN C 3 218 ? 177.161 245.001 321.574 1.00 76.74  ? 218 ASN C C   1 
ATOM 4967 O O   . ASN C 3 218 ? 178.211 245.398 321.061 1.00 76.89  ? 218 ASN C O   1 
ATOM 4968 C CB  . ASN C 3 218 ? 177.211 242.577 321.009 1.00 73.57  ? 218 ASN C CB  1 
ATOM 4969 C CG  . ASN C 3 218 ? 176.240 242.864 319.882 1.00 82.23  ? 218 ASN C CG  1 
ATOM 4970 O OD1 . ASN C 3 218 ? 175.196 243.482 320.089 1.00 80.17  ? 218 ASN C OD1 1 
ATOM 4971 N ND2 . ASN C 3 218 ? 176.580 242.415 318.679 1.00 79.88  ? 218 ASN C ND2 1 
ATOM 4972 N N   . ASP C 3 219 ? 176.065 245.759 321.639 1.00 68.67  ? 219 ASP C N   1 
ATOM 4973 C CA  . ASP C 3 219 ? 176.012 247.107 321.088 1.00 73.23  ? 219 ASP C CA  1 
ATOM 4974 C C   . ASP C 3 219 ? 175.939 248.177 322.173 1.00 70.41  ? 219 ASP C C   1 
ATOM 4975 O O   . ASP C 3 219 ? 175.464 249.285 321.912 1.00 69.69  ? 219 ASP C O   1 
ATOM 4976 C CB  . ASP C 3 219 ? 174.823 247.241 320.139 1.00 76.48  ? 219 ASP C CB  1 
ATOM 4977 C CG  . ASP C 3 219 ? 173.494 247.050 320.839 1.00 79.02  ? 219 ASP C CG  1 
ATOM 4978 O OD1 . ASP C 3 219 ? 173.088 247.946 321.609 1.00 73.63  ? 219 ASP C OD1 1 
ATOM 4979 O OD2 . ASP C 3 219 ? 172.852 246.004 320.617 1.00 81.05  ? 219 ASP C OD2 1 
ATOM 4980 N N   . PHE C 3 220 ? 176.395 247.870 323.382 1.00 53.97  ? 220 PHE C N   1 
ATOM 4981 C CA  . PHE C 3 220 ? 176.361 248.834 324.467 1.00 44.71  ? 220 PHE C CA  1 
ATOM 4982 C C   . PHE C 3 220 ? 177.467 249.869 324.284 1.00 41.64  ? 220 PHE C C   1 
ATOM 4983 O O   . PHE C 3 220 ? 178.386 249.696 323.483 1.00 51.90  ? 220 PHE C O   1 
ATOM 4984 C CB  . PHE C 3 220 ? 176.504 248.119 325.807 1.00 45.96  ? 220 PHE C CB  1 
ATOM 4985 C CG  . PHE C 3 220 ? 175.923 248.872 326.962 1.00 36.76  ? 220 PHE C CG  1 
ATOM 4986 C CD1 . PHE C 3 220 ? 174.571 248.826 327.223 1.00 47.47  ? 220 PHE C CD1 1 
ATOM 4987 C CD2 . PHE C 3 220 ? 176.730 249.616 327.795 1.00 40.49  ? 220 PHE C CD2 1 
ATOM 4988 C CE1 . PHE C 3 220 ? 174.038 249.514 328.285 1.00 49.56  ? 220 PHE C CE1 1 
ATOM 4989 C CE2 . PHE C 3 220 ? 176.201 250.304 328.857 1.00 48.06  ? 220 PHE C CE2 1 
ATOM 4990 C CZ  . PHE C 3 220 ? 174.854 250.253 329.102 1.00 44.23  ? 220 PHE C CZ  1 
ATOM 4991 N N   . SER C 3 221 ? 177.370 250.963 325.034 1.00 41.70  ? 221 SER C N   1 
ATOM 4992 C CA  . SER C 3 221 ? 178.372 252.016 324.947 1.00 41.41  ? 221 SER C CA  1 
ATOM 4993 C C   . SER C 3 221 ? 178.112 253.047 326.032 1.00 36.69  ? 221 SER C C   1 
ATOM 4994 O O   . SER C 3 221 ? 176.985 253.189 326.512 1.00 44.34  ? 221 SER C O   1 
ATOM 4995 C CB  . SER C 3 221 ? 178.361 252.685 323.571 1.00 45.41  ? 221 SER C CB  1 
ATOM 4996 O OG  . SER C 3 221 ? 179.309 253.734 323.516 1.00 54.18  ? 221 SER C OG  1 
ATOM 4997 N N   . VAL C 3 222 ? 179.172 253.761 326.411 1.00 35.59  ? 222 VAL C N   1 
ATOM 4998 C CA  . VAL C 3 222 ? 179.104 254.814 327.413 1.00 38.55  ? 222 VAL C CA  1 
ATOM 4999 C C   . VAL C 3 222 ? 179.961 255.979 326.942 1.00 46.05  ? 222 VAL C C   1 
ATOM 5000 O O   . VAL C 3 222 ? 180.701 255.876 325.961 1.00 52.63  ? 222 VAL C O   1 
ATOM 5001 C CB  . VAL C 3 222 ? 179.563 254.329 328.800 1.00 42.53  ? 222 VAL C CB  1 
ATOM 5002 C CG1 . VAL C 3 222 ? 178.501 253.457 329.424 1.00 50.56  ? 222 VAL C CG1 1 
ATOM 5003 C CG2 . VAL C 3 222 ? 180.868 253.571 328.685 1.00 45.56  ? 222 VAL C CG2 1 
ATOM 5004 N N   . ARG C 3 223 ? 179.856 257.100 327.654 1.00 54.36  ? 223 ARG C N   1 
ATOM 5005 C CA  . ARG C 3 223 ? 180.519 258.322 327.222 1.00 49.76  ? 223 ARG C CA  1 
ATOM 5006 C C   . ARG C 3 223 ? 180.716 259.265 328.401 1.00 48.00  ? 223 ARG C C   1 
ATOM 5007 O O   . ARG C 3 223 ? 180.016 259.176 329.411 1.00 58.52  ? 223 ARG C O   1 
ATOM 5008 C CB  . ARG C 3 223 ? 179.705 259.011 326.125 1.00 44.19  ? 223 ARG C CB  1 
ATOM 5009 C CG  . ARG C 3 223 ? 180.493 259.970 325.272 1.00 56.35  ? 223 ARG C CG  1 
ATOM 5010 C CD  . ARG C 3 223 ? 179.670 260.435 324.089 1.00 62.84  ? 223 ARG C CD  1 
ATOM 5011 N NE  . ARG C 3 223 ? 178.605 261.353 324.472 1.00 55.32  ? 223 ARG C NE  1 
ATOM 5012 C CZ  . ARG C 3 223 ? 177.657 261.778 323.650 1.00 54.12  ? 223 ARG C CZ  1 
ATOM 5013 N NH1 . ARG C 3 223 ? 177.591 261.362 322.397 1.00 60.52  ? 223 ARG C NH1 1 
ATOM 5014 N NH2 . ARG C 3 223 ? 176.751 262.641 324.096 1.00 56.09  ? 223 ARG C NH2 1 
ATOM 5015 N N   . LEU C 3 224 ? 181.683 260.172 328.255 1.00 35.44  ? 224 LEU C N   1 
ATOM 5016 C CA  . LEU C 3 224 ? 181.876 261.275 329.191 1.00 44.05  ? 224 LEU C CA  1 
ATOM 5017 C C   . LEU C 3 224 ? 182.136 260.824 330.623 1.00 48.46  ? 224 LEU C C   1 
ATOM 5018 O O   . LEU C 3 224 ? 181.270 260.984 331.488 1.00 55.53  ? 224 LEU C O   1 
ATOM 5019 C CB  . LEU C 3 224 ? 180.662 262.205 329.164 1.00 50.29  ? 224 LEU C CB  1 
ATOM 5020 C CG  . LEU C 3 224 ? 180.866 263.552 329.858 1.00 45.71  ? 224 LEU C CG  1 
ATOM 5021 C CD1 . LEU C 3 224 ? 181.777 264.443 329.037 1.00 41.46  ? 224 LEU C CD1 1 
ATOM 5022 C CD2 . LEU C 3 224 ? 179.540 264.242 330.108 1.00 51.86  ? 224 LEU C CD2 1 
ATOM 5023 N N   . LEU C 3 225 ? 183.305 260.245 330.879 1.00 46.35  ? 225 LEU C N   1 
ATOM 5024 C CA  . LEU C 3 225 ? 183.703 259.821 332.215 1.00 43.23  ? 225 LEU C CA  1 
ATOM 5025 C C   . LEU C 3 225 ? 183.331 260.865 333.259 1.00 41.81  ? 225 LEU C C   1 
ATOM 5026 O O   . LEU C 3 225 ? 183.378 262.069 333.002 1.00 45.23  ? 225 LEU C O   1 
ATOM 5027 C CB  . LEU C 3 225 ? 185.212 259.585 332.275 1.00 39.02  ? 225 LEU C CB  1 
ATOM 5028 C CG  . LEU C 3 225 ? 185.672 258.295 332.944 1.00 42.20  ? 225 LEU C CG  1 
ATOM 5029 C CD1 . LEU C 3 225 ? 185.938 257.256 331.882 1.00 50.89  ? 225 LEU C CD1 1 
ATOM 5030 C CD2 . LEU C 3 225 ? 186.900 258.529 333.798 1.00 40.44  ? 225 LEU C CD2 1 
ATOM 5031 N N   . ARG C 3 226 ? 182.951 260.389 334.448 1.00 49.10  ? 226 ARG C N   1 
ATOM 5032 C CA  . ARG C 3 226 ? 182.613 261.270 335.563 1.00 48.60  ? 226 ARG C CA  1 
ATOM 5033 C C   . ARG C 3 226 ? 183.532 261.055 336.757 1.00 54.98  ? 226 ARG C C   1 
ATOM 5034 O O   . ARG C 3 226 ? 184.146 262.014 337.232 1.00 63.26  ? 226 ARG C O   1 
ATOM 5035 C CB  . ARG C 3 226 ? 181.151 261.071 335.977 1.00 51.17  ? 226 ARG C CB  1 
ATOM 5036 C CG  . ARG C 3 226 ? 180.455 262.366 336.346 1.00 51.78  ? 226 ARG C CG  1 
ATOM 5037 C CD  . ARG C 3 226 ? 179.278 262.135 337.269 1.00 56.81  ? 226 ARG C CD  1 
ATOM 5038 N NE  . ARG C 3 226 ? 178.411 261.063 336.802 1.00 60.36  ? 226 ARG C NE  1 
ATOM 5039 C CZ  . ARG C 3 226 ? 177.401 261.224 335.959 1.00 63.71  ? 226 ARG C CZ  1 
ATOM 5040 N NH1 . ARG C 3 226 ? 177.105 262.409 335.450 1.00 60.09  ? 226 ARG C NH1 1 
ATOM 5041 N NH2 . ARG C 3 226 ? 176.669 260.168 335.616 1.00 62.78  ? 226 ARG C NH2 1 
ATOM 5042 N N   . ASP C 3 227 ? 183.649 259.828 337.261 1.00 58.62  ? 227 ASP C N   1 
ATOM 5043 C CA  . ASP C 3 227 ? 184.586 259.509 338.337 1.00 56.29  ? 227 ASP C CA  1 
ATOM 5044 C C   . ASP C 3 227 ? 184.286 260.327 339.597 1.00 53.97  ? 227 ASP C C   1 
ATOM 5045 O O   . ASP C 3 227 ? 185.071 261.171 340.028 1.00 59.54  ? 227 ASP C O   1 
ATOM 5046 C CB  . ASP C 3 227 ? 186.023 259.731 337.861 1.00 60.41  ? 227 ASP C CB  1 
ATOM 5047 C CG  . ASP C 3 227 ? 187.044 259.077 338.762 1.00 67.34  ? 227 ASP C CG  1 
ATOM 5048 O OD1 . ASP C 3 227 ? 186.818 259.028 339.989 1.00 69.78  ? 227 ASP C OD1 1 
ATOM 5049 O OD2 . ASP C 3 227 ? 188.077 258.610 338.239 1.00 68.47  ? 227 ASP C OD2 1 
ATOM 5050 N N   . THR C 3 228 ? 183.120 260.060 340.183 1.00 60.22  ? 228 THR C N   1 
ATOM 5051 C CA  . THR C 3 228 ? 182.658 260.752 341.379 1.00 63.23  ? 228 THR C CA  1 
ATOM 5052 C C   . THR C 3 228 ? 183.124 260.082 342.670 1.00 67.88  ? 228 THR C C   1 
ATOM 5053 O O   . THR C 3 228 ? 182.572 260.363 343.739 1.00 68.79  ? 228 THR C O   1 
ATOM 5054 C CB  . THR C 3 228 ? 181.131 260.842 341.366 1.00 70.49  ? 228 THR C CB  1 
ATOM 5055 O OG1 . THR C 3 228 ? 180.693 261.331 340.095 1.00 73.33  ? 228 THR C OG1 1 
ATOM 5056 C CG2 . THR C 3 228 ? 180.628 261.778 342.451 1.00 71.36  ? 228 THR C CG2 1 
ATOM 5057 N N   . THR C 3 229 ? 184.134 259.218 342.601 1.00 74.04  ? 229 THR C N   1 
ATOM 5058 C CA  . THR C 3 229 ? 184.549 258.444 343.765 1.00 69.86  ? 229 THR C CA  1 
ATOM 5059 C C   . THR C 3 229 ? 185.303 259.304 344.771 1.00 65.66  ? 229 THR C C   1 
ATOM 5060 O O   . THR C 3 229 ? 186.534 259.380 344.730 1.00 67.92  ? 229 THR C O   1 
ATOM 5061 C CB  . THR C 3 229 ? 185.421 257.264 343.330 1.00 66.50  ? 229 THR C CB  1 
ATOM 5062 O OG1 . THR C 3 229 ? 184.765 256.547 342.280 1.00 69.59  ? 229 THR C OG1 1 
ATOM 5063 C CG2 . THR C 3 229 ? 185.674 256.316 344.493 1.00 68.83  ? 229 THR C CG2 1 
ATOM 5064 N N   . HIS C 3 230 ? 184.579 259.950 345.680 1.00 77.67  ? 230 HIS C N   1 
ATOM 5065 C CA  . HIS C 3 230 ? 185.198 260.666 346.781 1.00 79.42  ? 230 HIS C CA  1 
ATOM 5066 C C   . HIS C 3 230 ? 185.311 259.739 347.989 1.00 82.95  ? 230 HIS C C   1 
ATOM 5067 O O   . HIS C 3 230 ? 184.883 258.583 347.957 1.00 86.10  ? 230 HIS C O   1 
ATOM 5068 C CB  . HIS C 3 230 ? 184.400 261.921 347.121 1.00 81.94  ? 230 HIS C CB  1 
ATOM 5069 C CG  . HIS C 3 230 ? 183.024 261.640 347.631 1.00 86.56  ? 230 HIS C CG  1 
ATOM 5070 N ND1 . HIS C 3 230 ? 181.937 261.492 346.796 1.00 88.81  ? 230 HIS C ND1 1 
ATOM 5071 C CD2 . HIS C 3 230 ? 182.556 261.478 348.891 1.00 87.63  ? 230 HIS C CD2 1 
ATOM 5072 C CE1 . HIS C 3 230 ? 180.859 261.252 347.520 1.00 87.42  ? 230 HIS C CE1 1 
ATOM 5073 N NE2 . HIS C 3 230 ? 181.207 261.238 348.794 1.00 92.93  ? 230 HIS C NE2 1 
ATOM 5074 N N   . ILE C 3 231 ? 185.899 260.246 349.071 1.00 91.28  ? 231 ILE C N   1 
ATOM 5075 C CA  . ILE C 3 231 ? 186.080 259.451 350.281 1.00 93.14  ? 231 ILE C CA  1 
ATOM 5076 C C   . ILE C 3 231 ? 185.502 260.183 351.485 1.00 94.52  ? 231 ILE C C   1 
ATOM 5077 O O   . ILE C 3 231 ? 184.712 259.614 352.247 1.00 92.37  ? 231 ILE C O   1 
ATOM 5078 C CB  . ILE C 3 231 ? 187.564 259.106 350.504 1.00 92.90  ? 231 ILE C CB  1 
ATOM 5079 C CG1 . ILE C 3 231 ? 187.718 258.218 351.741 1.00 91.73  ? 231 ILE C CG1 1 
ATOM 5080 C CG2 . ILE C 3 231 ? 188.407 260.368 350.645 1.00 90.95  ? 231 ILE C CG2 1 
ATOM 5081 C CD1 . ILE C 3 231 ? 189.087 257.588 351.880 1.00 92.56  ? 231 ILE C CD1 1 
ATOM 5082 N N   . GLU C 3 232 ? 185.892 261.439 351.669 1.00 106.11 ? 232 GLU C N   1 
ATOM 5083 C CA  . GLU C 3 232 ? 185.500 262.199 352.851 1.00 107.36 ? 232 GLU C CA  1 
ATOM 5084 C C   . GLU C 3 232 ? 183.984 262.233 353.006 1.00 104.42 ? 232 GLU C C   1 
ATOM 5085 O O   . GLU C 3 232 ? 183.452 261.876 354.057 1.00 102.39 ? 232 GLU C O   1 
ATOM 5086 C CB  . GLU C 3 232 ? 186.053 263.625 352.777 1.00 104.88 ? 232 GLU C CB  1 
ATOM 5087 C CG  . GLU C 3 232 ? 185.883 264.426 354.059 1.00 105.47 ? 232 GLU C CG  1 
ATOM 5088 C CD  . GLU C 3 232 ? 186.688 263.860 355.213 1.00 106.26 ? 232 GLU C CD  1 
ATOM 5089 O OE1 . GLU C 3 232 ? 187.546 262.986 354.970 1.00 105.00 ? 232 GLU C OE1 1 
ATOM 5090 O OE2 . GLU C 3 232 ? 186.464 264.289 356.364 1.00 103.86 ? 232 GLU C OE2 1 
# 
