data_9EYY
# 
_entry.id   9EYY 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9EYY         pdb_00009eyy 10.2210/pdb9eyy/pdb 
WWPDB D_1292137794 ?            ?                   
EMDB  EMD-50064    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9EYY 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-09 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        
'Poliovirus type 1 (strain Mahoney) native conformation stabilised virus-like particle (PV1 SC6b) from a yeast expression system.' 
_pdbx_database_related.db_id          EMD-50064 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              dave.stuart@strubi.ox.ac.uk 
_pdbx_contact_author.name_first         David 
_pdbx_contact_author.name_last          Stuart 
_pdbx_contact_author.name_mi            I. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3426-4210 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bahar, M.W.'      1 0000-0002-2350-2682 
'Sherry, L.'       2 0000-0002-4367-772X 
'Stonehouse, N.J.' 3 0000-0003-1146-5519 
'Rowlands, D.J.'   4 0000-0002-4742-9272 
'Fry, E.E.'        5 0000-0001-9754-5303 
'Stuart, D.I.'     6 0000-0002-3426-4210 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                831 
_citation.page_last                 831 
_citation.title                     
'Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-025-56118-z 
_citation.pdbx_database_id_PubMed   39827284 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sherry, L.'         1  0000-0002-4367-772X 
primary 'Bahar, M.W.'        2  0000-0002-2350-2682 
primary 'Porta, C.'          3  ?                   
primary 'Fox, H.'            4  ?                   
primary 'Grehan, K.'         5  0000-0003-3976-756X 
primary 'Nasta, V.'          6  ?                   
primary 'Duyvesteyn, H.M.E.' 7  ?                   
primary 'De Colibus, L.'     8  ?                   
primary 'Marsian, J.'        9  ?                   
primary 'Murdoch, I.'        10 ?                   
primary 'Ponndorf, D.'       11 ?                   
primary 'Kim, S.R.'          12 ?                   
primary 'Shah, S.'           13 ?                   
primary 'Carlyle, S.'        14 0000-0002-7158-8134 
primary 'Swanson, J.J.'      15 ?                   
primary 'Matthews, S.'       16 ?                   
primary 'Nicol, C.'          17 ?                   
primary 'Lomonossoff, G.P.'  18 0000-0003-0700-906X 
primary 'Macadam, A.J.'      19 0000-0002-8687-1573 
primary 'Fry, E.E.'          20 0000-0001-9754-5303 
primary 'Stuart, D.I.'       21 0000-0002-3426-4210 
primary 'Stonehouse, N.J.'   22 0000-0003-1146-5519 
primary 'Rowlands, D.J.'     23 0000-0002-4742-9272 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Capsid protein VP1' 33447.586 1 ? 'VP1 H248P'                     ? ? 
2 polymer     man 'Capsid protein VP0' 37465.812 1 ? 'VP2 T94A, VP2 D126E, VP4 R18G' ? ? 
3 polymer     man 'Capsid protein VP3' 26550.549 1 ? 'VP3 L119M, VP3 Q178L'          ? ? 
4 non-polymer syn 'PALMITIC ACID'      256.424   1 ? ?                               ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'P1D,Virion protein 1' 
2 VP4-VP2                
3 'P1C,Virion protein 3' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESF
FARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYV
PPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGIL
AVRVVNDPNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY
;
;GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESF
FARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYV
PPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGIL
AVRVVNDPNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY
;
A ? 
2 'polypeptide(L)' no no 
;MGAQVSSQKVGAHENSNGAYGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSD
RVLQLTLGNSTITAQEAANSVVAYGRWPEYLRDSEANPVDQPTEPEVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGL
FGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPA
RRFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITL
TIAPMCCEFNGLRNITLPRLQ
;
;MGAQVSSQKVGAHENSNGAYGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSD
RVLQLTLGNSTITAQEAANSVVAYGRWPEYLRDSEANPVDQPTEPEVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGL
FGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPA
RRFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITL
TIAPMCCEFNGLRNITLPRLQ
;
B ? 
3 'polypeptide(L)' no no 
;GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDD
PILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFMFCGSMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRLTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQ
;
;GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDD
PILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFMFCGSMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRLTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQ
;
C ? 
# 
_pdbx_entity_nonpoly.entity_id   4 
_pdbx_entity_nonpoly.name        'PALMITIC ACID' 
_pdbx_entity_nonpoly.comp_id     PLM 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   LEU n 
1 3   GLY n 
1 4   GLN n 
1 5   MET n 
1 6   LEU n 
1 7   GLU n 
1 8   SER n 
1 9   MET n 
1 10  ILE n 
1 11  ASP n 
1 12  ASN n 
1 13  THR n 
1 14  VAL n 
1 15  ARG n 
1 16  GLU n 
1 17  THR n 
1 18  VAL n 
1 19  GLY n 
1 20  ALA n 
1 21  ALA n 
1 22  THR n 
1 23  SER n 
1 24  ARG n 
1 25  ASP n 
1 26  ALA n 
1 27  LEU n 
1 28  PRO n 
1 29  ASN n 
1 30  THR n 
1 31  GLU n 
1 32  ALA n 
1 33  SER n 
1 34  GLY n 
1 35  PRO n 
1 36  THR n 
1 37  HIS n 
1 38  SER n 
1 39  LYS n 
1 40  GLU n 
1 41  ILE n 
1 42  PRO n 
1 43  ALA n 
1 44  LEU n 
1 45  THR n 
1 46  ALA n 
1 47  VAL n 
1 48  GLU n 
1 49  THR n 
1 50  GLY n 
1 51  ALA n 
1 52  THR n 
1 53  ASN n 
1 54  PRO n 
1 55  LEU n 
1 56  VAL n 
1 57  PRO n 
1 58  SER n 
1 59  ASP n 
1 60  THR n 
1 61  VAL n 
1 62  GLN n 
1 63  THR n 
1 64  ARG n 
1 65  HIS n 
1 66  VAL n 
1 67  VAL n 
1 68  GLN n 
1 69  HIS n 
1 70  ARG n 
1 71  SER n 
1 72  ARG n 
1 73  SER n 
1 74  GLU n 
1 75  SER n 
1 76  SER n 
1 77  ILE n 
1 78  GLU n 
1 79  SER n 
1 80  PHE n 
1 81  PHE n 
1 82  ALA n 
1 83  ARG n 
1 84  GLY n 
1 85  ALA n 
1 86  CYS n 
1 87  VAL n 
1 88  THR n 
1 89  ILE n 
1 90  MET n 
1 91  THR n 
1 92  VAL n 
1 93  ASP n 
1 94  ASN n 
1 95  PRO n 
1 96  ALA n 
1 97  SER n 
1 98  THR n 
1 99  THR n 
1 100 ASN n 
1 101 LYS n 
1 102 ASP n 
1 103 LYS n 
1 104 LEU n 
1 105 PHE n 
1 106 ALA n 
1 107 VAL n 
1 108 TRP n 
1 109 LYS n 
1 110 ILE n 
1 111 THR n 
1 112 TYR n 
1 113 LYS n 
1 114 ASP n 
1 115 THR n 
1 116 VAL n 
1 117 GLN n 
1 118 LEU n 
1 119 ARG n 
1 120 ARG n 
1 121 LYS n 
1 122 LEU n 
1 123 GLU n 
1 124 PHE n 
1 125 PHE n 
1 126 THR n 
1 127 TYR n 
1 128 SER n 
1 129 ARG n 
1 130 PHE n 
1 131 ASP n 
1 132 MET n 
1 133 GLU n 
1 134 LEU n 
1 135 THR n 
1 136 PHE n 
1 137 VAL n 
1 138 VAL n 
1 139 THR n 
1 140 ALA n 
1 141 ASN n 
1 142 PHE n 
1 143 THR n 
1 144 GLU n 
1 145 THR n 
1 146 ASN n 
1 147 ASN n 
1 148 GLY n 
1 149 HIS n 
1 150 ALA n 
1 151 LEU n 
1 152 ASN n 
1 153 GLN n 
1 154 VAL n 
1 155 TYR n 
1 156 GLN n 
1 157 ILE n 
1 158 MET n 
1 159 TYR n 
1 160 VAL n 
1 161 PRO n 
1 162 PRO n 
1 163 GLY n 
1 164 ALA n 
1 165 PRO n 
1 166 VAL n 
1 167 PRO n 
1 168 GLU n 
1 169 LYS n 
1 170 TRP n 
1 171 ASP n 
1 172 ASP n 
1 173 TYR n 
1 174 THR n 
1 175 TRP n 
1 176 GLN n 
1 177 THR n 
1 178 SER n 
1 179 SER n 
1 180 ASN n 
1 181 PRO n 
1 182 SER n 
1 183 ILE n 
1 184 PHE n 
1 185 TYR n 
1 186 THR n 
1 187 TYR n 
1 188 GLY n 
1 189 THR n 
1 190 ALA n 
1 191 PRO n 
1 192 ALA n 
1 193 ARG n 
1 194 ILE n 
1 195 SER n 
1 196 VAL n 
1 197 PRO n 
1 198 TYR n 
1 199 VAL n 
1 200 GLY n 
1 201 ILE n 
1 202 SER n 
1 203 ASN n 
1 204 ALA n 
1 205 TYR n 
1 206 SER n 
1 207 HIS n 
1 208 PHE n 
1 209 TYR n 
1 210 ASP n 
1 211 GLY n 
1 212 PHE n 
1 213 SER n 
1 214 LYS n 
1 215 VAL n 
1 216 PRO n 
1 217 LEU n 
1 218 LYS n 
1 219 ASP n 
1 220 GLN n 
1 221 SER n 
1 222 ALA n 
1 223 ALA n 
1 224 LEU n 
1 225 GLY n 
1 226 ASP n 
1 227 SER n 
1 228 LEU n 
1 229 TYR n 
1 230 GLY n 
1 231 ALA n 
1 232 ALA n 
1 233 SER n 
1 234 LEU n 
1 235 ASN n 
1 236 ASP n 
1 237 PHE n 
1 238 GLY n 
1 239 ILE n 
1 240 LEU n 
1 241 ALA n 
1 242 VAL n 
1 243 ARG n 
1 244 VAL n 
1 245 VAL n 
1 246 ASN n 
1 247 ASP n 
1 248 PRO n 
1 249 ASN n 
1 250 PRO n 
1 251 THR n 
1 252 LYS n 
1 253 VAL n 
1 254 THR n 
1 255 SER n 
1 256 LYS n 
1 257 ILE n 
1 258 ARG n 
1 259 VAL n 
1 260 TYR n 
1 261 LEU n 
1 262 LYS n 
1 263 PRO n 
1 264 LYS n 
1 265 HIS n 
1 266 ILE n 
1 267 ARG n 
1 268 VAL n 
1 269 TRP n 
1 270 CYS n 
1 271 PRO n 
1 272 ARG n 
1 273 PRO n 
1 274 PRO n 
1 275 ARG n 
1 276 ALA n 
1 277 VAL n 
1 278 ALA n 
1 279 TYR n 
1 280 TYR n 
1 281 GLY n 
1 282 PRO n 
1 283 GLY n 
1 284 VAL n 
1 285 ASP n 
1 286 TYR n 
1 287 LYS n 
1 288 ASP n 
1 289 GLY n 
1 290 THR n 
1 291 LEU n 
1 292 THR n 
1 293 PRO n 
1 294 LEU n 
1 295 SER n 
1 296 THR n 
1 297 LYS n 
1 298 ASP n 
1 299 LEU n 
1 300 THR n 
1 301 THR n 
1 302 TYR n 
2 1   MET n 
2 2   GLY n 
2 3   ALA n 
2 4   GLN n 
2 5   VAL n 
2 6   SER n 
2 7   SER n 
2 8   GLN n 
2 9   LYS n 
2 10  VAL n 
2 11  GLY n 
2 12  ALA n 
2 13  HIS n 
2 14  GLU n 
2 15  ASN n 
2 16  SER n 
2 17  ASN n 
2 18  GLY n 
2 19  ALA n 
2 20  TYR n 
2 21  GLY n 
2 22  GLY n 
2 23  SER n 
2 24  THR n 
2 25  ILE n 
2 26  ASN n 
2 27  TYR n 
2 28  THR n 
2 29  THR n 
2 30  ILE n 
2 31  ASN n 
2 32  TYR n 
2 33  TYR n 
2 34  ARG n 
2 35  ASP n 
2 36  SER n 
2 37  ALA n 
2 38  SER n 
2 39  ASN n 
2 40  ALA n 
2 41  ALA n 
2 42  SER n 
2 43  LYS n 
2 44  GLN n 
2 45  ASP n 
2 46  PHE n 
2 47  SER n 
2 48  GLN n 
2 49  ASP n 
2 50  PRO n 
2 51  SER n 
2 52  LYS n 
2 53  PHE n 
2 54  THR n 
2 55  GLU n 
2 56  PRO n 
2 57  ILE n 
2 58  LYS n 
2 59  ASP n 
2 60  VAL n 
2 61  LEU n 
2 62  ILE n 
2 63  LYS n 
2 64  THR n 
2 65  ALA n 
2 66  PRO n 
2 67  MET n 
2 68  LEU n 
2 69  ASN n 
2 70  SER n 
2 71  PRO n 
2 72  ASN n 
2 73  ILE n 
2 74  GLU n 
2 75  ALA n 
2 76  CYS n 
2 77  GLY n 
2 78  TYR n 
2 79  SER n 
2 80  ASP n 
2 81  ARG n 
2 82  VAL n 
2 83  LEU n 
2 84  GLN n 
2 85  LEU n 
2 86  THR n 
2 87  LEU n 
2 88  GLY n 
2 89  ASN n 
2 90  SER n 
2 91  THR n 
2 92  ILE n 
2 93  THR n 
2 94  ALA n 
2 95  GLN n 
2 96  GLU n 
2 97  ALA n 
2 98  ALA n 
2 99  ASN n 
2 100 SER n 
2 101 VAL n 
2 102 VAL n 
2 103 ALA n 
2 104 TYR n 
2 105 GLY n 
2 106 ARG n 
2 107 TRP n 
2 108 PRO n 
2 109 GLU n 
2 110 TYR n 
2 111 LEU n 
2 112 ARG n 
2 113 ASP n 
2 114 SER n 
2 115 GLU n 
2 116 ALA n 
2 117 ASN n 
2 118 PRO n 
2 119 VAL n 
2 120 ASP n 
2 121 GLN n 
2 122 PRO n 
2 123 THR n 
2 124 GLU n 
2 125 PRO n 
2 126 GLU n 
2 127 VAL n 
2 128 ALA n 
2 129 ALA n 
2 130 CYS n 
2 131 ARG n 
2 132 PHE n 
2 133 TYR n 
2 134 THR n 
2 135 LEU n 
2 136 ASP n 
2 137 THR n 
2 138 VAL n 
2 139 SER n 
2 140 TRP n 
2 141 THR n 
2 142 LYS n 
2 143 GLU n 
2 144 SER n 
2 145 ARG n 
2 146 GLY n 
2 147 TRP n 
2 148 TRP n 
2 149 TRP n 
2 150 LYS n 
2 151 LEU n 
2 152 PRO n 
2 153 ASP n 
2 154 ALA n 
2 155 LEU n 
2 156 ARG n 
2 157 ASP n 
2 158 MET n 
2 159 GLY n 
2 160 LEU n 
2 161 PHE n 
2 162 GLY n 
2 163 GLN n 
2 164 ASN n 
2 165 MET n 
2 166 TYR n 
2 167 TYR n 
2 168 HIS n 
2 169 TYR n 
2 170 LEU n 
2 171 GLY n 
2 172 ARG n 
2 173 SER n 
2 174 GLY n 
2 175 TYR n 
2 176 THR n 
2 177 VAL n 
2 178 HIS n 
2 179 VAL n 
2 180 GLN n 
2 181 CYS n 
2 182 ASN n 
2 183 ALA n 
2 184 SER n 
2 185 LYS n 
2 186 PHE n 
2 187 HIS n 
2 188 GLN n 
2 189 GLY n 
2 190 ALA n 
2 191 LEU n 
2 192 GLY n 
2 193 VAL n 
2 194 PHE n 
2 195 ALA n 
2 196 VAL n 
2 197 PRO n 
2 198 GLU n 
2 199 MET n 
2 200 CYS n 
2 201 LEU n 
2 202 ALA n 
2 203 GLY n 
2 204 ASP n 
2 205 SER n 
2 206 ASN n 
2 207 THR n 
2 208 THR n 
2 209 THR n 
2 210 MET n 
2 211 HIS n 
2 212 THR n 
2 213 SER n 
2 214 TYR n 
2 215 GLN n 
2 216 ASN n 
2 217 ALA n 
2 218 ASN n 
2 219 PRO n 
2 220 GLY n 
2 221 GLU n 
2 222 LYS n 
2 223 GLY n 
2 224 GLY n 
2 225 THR n 
2 226 PHE n 
2 227 THR n 
2 228 GLY n 
2 229 THR n 
2 230 PHE n 
2 231 THR n 
2 232 PRO n 
2 233 ASP n 
2 234 ASN n 
2 235 ASN n 
2 236 GLN n 
2 237 THR n 
2 238 SER n 
2 239 PRO n 
2 240 ALA n 
2 241 ARG n 
2 242 ARG n 
2 243 PHE n 
2 244 CYS n 
2 245 PRO n 
2 246 VAL n 
2 247 ASP n 
2 248 TYR n 
2 249 LEU n 
2 250 LEU n 
2 251 GLY n 
2 252 ASN n 
2 253 GLY n 
2 254 THR n 
2 255 LEU n 
2 256 LEU n 
2 257 GLY n 
2 258 ASN n 
2 259 ALA n 
2 260 PHE n 
2 261 VAL n 
2 262 PHE n 
2 263 PRO n 
2 264 HIS n 
2 265 GLN n 
2 266 ILE n 
2 267 ILE n 
2 268 ASN n 
2 269 LEU n 
2 270 ARG n 
2 271 THR n 
2 272 ASN n 
2 273 ASN n 
2 274 CYS n 
2 275 ALA n 
2 276 THR n 
2 277 LEU n 
2 278 VAL n 
2 279 LEU n 
2 280 PRO n 
2 281 TYR n 
2 282 VAL n 
2 283 ASN n 
2 284 SER n 
2 285 LEU n 
2 286 SER n 
2 287 ILE n 
2 288 ASP n 
2 289 SER n 
2 290 MET n 
2 291 VAL n 
2 292 LYS n 
2 293 HIS n 
2 294 ASN n 
2 295 ASN n 
2 296 TRP n 
2 297 GLY n 
2 298 ILE n 
2 299 ALA n 
2 300 ILE n 
2 301 LEU n 
2 302 PRO n 
2 303 LEU n 
2 304 ALA n 
2 305 PRO n 
2 306 LEU n 
2 307 ASN n 
2 308 PHE n 
2 309 ALA n 
2 310 SER n 
2 311 GLU n 
2 312 SER n 
2 313 SER n 
2 314 PRO n 
2 315 GLU n 
2 316 ILE n 
2 317 PRO n 
2 318 ILE n 
2 319 THR n 
2 320 LEU n 
2 321 THR n 
2 322 ILE n 
2 323 ALA n 
2 324 PRO n 
2 325 MET n 
2 326 CYS n 
2 327 CYS n 
2 328 GLU n 
2 329 PHE n 
2 330 ASN n 
2 331 GLY n 
2 332 LEU n 
2 333 ARG n 
2 334 ASN n 
2 335 ILE n 
2 336 THR n 
2 337 LEU n 
2 338 PRO n 
2 339 ARG n 
2 340 LEU n 
2 341 GLN n 
3 1   GLY n 
3 2   LEU n 
3 3   PRO n 
3 4   VAL n 
3 5   MET n 
3 6   ASN n 
3 7   THR n 
3 8   PRO n 
3 9   GLY n 
3 10  SER n 
3 11  ASN n 
3 12  GLN n 
3 13  TYR n 
3 14  LEU n 
3 15  THR n 
3 16  ALA n 
3 17  ASP n 
3 18  ASN n 
3 19  PHE n 
3 20  GLN n 
3 21  SER n 
3 22  PRO n 
3 23  CYS n 
3 24  ALA n 
3 25  LEU n 
3 26  PRO n 
3 27  GLU n 
3 28  PHE n 
3 29  ASP n 
3 30  VAL n 
3 31  THR n 
3 32  PRO n 
3 33  PRO n 
3 34  ILE n 
3 35  ASP n 
3 36  ILE n 
3 37  PRO n 
3 38  GLY n 
3 39  GLU n 
3 40  VAL n 
3 41  LYS n 
3 42  ASN n 
3 43  MET n 
3 44  MET n 
3 45  GLU n 
3 46  LEU n 
3 47  ALA n 
3 48  GLU n 
3 49  ILE n 
3 50  ASP n 
3 51  THR n 
3 52  MET n 
3 53  ILE n 
3 54  PRO n 
3 55  PHE n 
3 56  ASP n 
3 57  LEU n 
3 58  SER n 
3 59  ALA n 
3 60  THR n 
3 61  LYS n 
3 62  LYS n 
3 63  ASN n 
3 64  THR n 
3 65  MET n 
3 66  GLU n 
3 67  MET n 
3 68  TYR n 
3 69  ARG n 
3 70  VAL n 
3 71  ARG n 
3 72  LEU n 
3 73  SER n 
3 74  ASP n 
3 75  LYS n 
3 76  PRO n 
3 77  HIS n 
3 78  THR n 
3 79  ASP n 
3 80  ASP n 
3 81  PRO n 
3 82  ILE n 
3 83  LEU n 
3 84  CYS n 
3 85  LEU n 
3 86  SER n 
3 87  LEU n 
3 88  SER n 
3 89  PRO n 
3 90  ALA n 
3 91  SER n 
3 92  ASP n 
3 93  PRO n 
3 94  ARG n 
3 95  LEU n 
3 96  SER n 
3 97  HIS n 
3 98  THR n 
3 99  MET n 
3 100 LEU n 
3 101 GLY n 
3 102 GLU n 
3 103 ILE n 
3 104 LEU n 
3 105 ASN n 
3 106 TYR n 
3 107 TYR n 
3 108 THR n 
3 109 HIS n 
3 110 TRP n 
3 111 ALA n 
3 112 GLY n 
3 113 SER n 
3 114 LEU n 
3 115 LYS n 
3 116 PHE n 
3 117 THR n 
3 118 PHE n 
3 119 MET n 
3 120 PHE n 
3 121 CYS n 
3 122 GLY n 
3 123 SER n 
3 124 MET n 
3 125 MET n 
3 126 ALA n 
3 127 THR n 
3 128 GLY n 
3 129 LYS n 
3 130 LEU n 
3 131 LEU n 
3 132 VAL n 
3 133 SER n 
3 134 TYR n 
3 135 ALA n 
3 136 PRO n 
3 137 PRO n 
3 138 GLY n 
3 139 ALA n 
3 140 ASP n 
3 141 PRO n 
3 142 PRO n 
3 143 LYS n 
3 144 LYS n 
3 145 ARG n 
3 146 LYS n 
3 147 GLU n 
3 148 ALA n 
3 149 MET n 
3 150 LEU n 
3 151 GLY n 
3 152 THR n 
3 153 HIS n 
3 154 VAL n 
3 155 ILE n 
3 156 TRP n 
3 157 ASP n 
3 158 ILE n 
3 159 GLY n 
3 160 LEU n 
3 161 GLN n 
3 162 SER n 
3 163 SER n 
3 164 CYS n 
3 165 THR n 
3 166 MET n 
3 167 VAL n 
3 168 VAL n 
3 169 PRO n 
3 170 TRP n 
3 171 ILE n 
3 172 SER n 
3 173 ASN n 
3 174 THR n 
3 175 THR n 
3 176 TYR n 
3 177 ARG n 
3 178 LEU n 
3 179 THR n 
3 180 ILE n 
3 181 ASP n 
3 182 ASP n 
3 183 SER n 
3 184 PHE n 
3 185 THR n 
3 186 GLU n 
3 187 GLY n 
3 188 GLY n 
3 189 TYR n 
3 190 ILE n 
3 191 SER n 
3 192 VAL n 
3 193 PHE n 
3 194 TYR n 
3 195 GLN n 
3 196 THR n 
3 197 ARG n 
3 198 ILE n 
3 199 VAL n 
3 200 VAL n 
3 201 PRO n 
3 202 LEU n 
3 203 SER n 
3 204 THR n 
3 205 PRO n 
3 206 ARG n 
3 207 GLU n 
3 208 MET n 
3 209 ASP n 
3 210 ILE n 
3 211 LEU n 
3 212 GLY n 
3 213 PHE n 
3 214 VAL n 
3 215 SER n 
3 216 ALA n 
3 217 CYS n 
3 218 ASN n 
3 219 ASP n 
3 220 PHE n 
3 221 SER n 
3 222 VAL n 
3 223 ARG n 
3 224 LEU n 
3 225 LEU n 
3 226 ARG n 
3 227 ASP n 
3 228 THR n 
3 229 THR n 
3 230 HIS n 
3 231 ILE n 
3 232 GLU n 
3 233 GLN n 
3 234 LYS n 
3 235 ALA n 
3 236 LEU n 
3 237 ALA n 
3 238 GLN n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 302 ? ? ? ? ? ? ? ? ? 'Human poliovirus 1 Mahoney' 12081 ? ? ? ? ? ? ? ? 
'Komagataella pastoris' 4922 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 341 ? ? ? ? ? ? ? ? ? 'Human poliovirus 1 Mahoney' 12081 ? ? ? ? ? ? ? ? 
'Komagataella pastoris' 4922 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 238 ? ? ? ? ? ? ? ? ? 'Human poliovirus 1 Mahoney' 12081 ? ? ? ? ? ? ? ? 
'Komagataella pastoris' 4922 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PLM non-polymer         . 'PALMITIC ACID' ? 'C16 H32 O2'     256.424 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   1   ?   ?   ?   A . n 
A 1 2   LEU 2   2   ?   ?   ?   A . n 
A 1 3   GLY 3   3   ?   ?   ?   A . n 
A 1 4   GLN 4   4   ?   ?   ?   A . n 
A 1 5   MET 5   5   ?   ?   ?   A . n 
A 1 6   LEU 6   6   ?   ?   ?   A . n 
A 1 7   GLU 7   7   ?   ?   ?   A . n 
A 1 8   SER 8   8   ?   ?   ?   A . n 
A 1 9   MET 9   9   ?   ?   ?   A . n 
A 1 10  ILE 10  10  ?   ?   ?   A . n 
A 1 11  ASP 11  11  ?   ?   ?   A . n 
A 1 12  ASN 12  12  ?   ?   ?   A . n 
A 1 13  THR 13  13  ?   ?   ?   A . n 
A 1 14  VAL 14  14  ?   ?   ?   A . n 
A 1 15  ARG 15  15  ?   ?   ?   A . n 
A 1 16  GLU 16  16  ?   ?   ?   A . n 
A 1 17  THR 17  17  ?   ?   ?   A . n 
A 1 18  VAL 18  18  ?   ?   ?   A . n 
A 1 19  GLY 19  19  ?   ?   ?   A . n 
A 1 20  ALA 20  20  ?   ?   ?   A . n 
A 1 21  ALA 21  21  ?   ?   ?   A . n 
A 1 22  THR 22  22  ?   ?   ?   A . n 
A 1 23  SER 23  23  ?   ?   ?   A . n 
A 1 24  ARG 24  24  ?   ?   ?   A . n 
A 1 25  ASP 25  25  25  ASP ASP A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  PRO 28  28  28  PRO PRO A . n 
A 1 29  ASN 29  29  29  ASN ASN A . n 
A 1 30  THR 30  30  30  THR THR A . n 
A 1 31  GLU 31  31  31  GLU GLU A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  SER 33  33  33  SER SER A . n 
A 1 34  GLY 34  34  34  GLY GLY A . n 
A 1 35  PRO 35  35  35  PRO PRO A . n 
A 1 36  THR 36  36  36  THR THR A . n 
A 1 37  HIS 37  37  37  HIS HIS A . n 
A 1 38  SER 38  38  38  SER SER A . n 
A 1 39  LYS 39  39  39  LYS LYS A . n 
A 1 40  GLU 40  40  40  GLU GLU A . n 
A 1 41  ILE 41  41  41  ILE ILE A . n 
A 1 42  PRO 42  42  42  PRO PRO A . n 
A 1 43  ALA 43  43  43  ALA ALA A . n 
A 1 44  LEU 44  44  44  LEU LEU A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  ALA 46  46  46  ALA ALA A . n 
A 1 47  VAL 47  47  47  VAL VAL A . n 
A 1 48  GLU 48  48  48  GLU GLU A . n 
A 1 49  THR 49  49  49  THR THR A . n 
A 1 50  GLY 50  50  50  GLY GLY A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  THR 52  52  52  THR THR A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  PRO 54  54  54  PRO PRO A . n 
A 1 55  LEU 55  55  55  LEU LEU A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  PRO 57  57  57  PRO PRO A . n 
A 1 58  SER 58  58  58  SER SER A . n 
A 1 59  ASP 59  59  59  ASP ASP A . n 
A 1 60  THR 60  60  60  THR THR A . n 
A 1 61  VAL 61  61  61  VAL VAL A . n 
A 1 62  GLN 62  62  62  GLN GLN A . n 
A 1 63  THR 63  63  63  THR THR A . n 
A 1 64  ARG 64  64  64  ARG ARG A . n 
A 1 65  HIS 65  65  65  HIS HIS A . n 
A 1 66  VAL 66  66  66  VAL VAL A . n 
A 1 67  VAL 67  67  67  VAL VAL A . n 
A 1 68  GLN 68  68  68  GLN GLN A . n 
A 1 69  HIS 69  69  69  HIS HIS A . n 
A 1 70  ARG 70  70  70  ARG ARG A . n 
A 1 71  SER 71  71  71  SER SER A . n 
A 1 72  ARG 72  72  72  ARG ARG A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  GLU 74  74  74  GLU GLU A . n 
A 1 75  SER 75  75  75  SER SER A . n 
A 1 76  SER 76  76  76  SER SER A . n 
A 1 77  ILE 77  77  77  ILE ILE A . n 
A 1 78  GLU 78  78  78  GLU GLU A . n 
A 1 79  SER 79  79  79  SER SER A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  ARG 83  83  83  ARG ARG A . n 
A 1 84  GLY 84  84  84  GLY GLY A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  CYS 86  86  86  CYS CYS A . n 
A 1 87  VAL 87  87  87  VAL VAL A . n 
A 1 88  THR 88  88  88  THR THR A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  MET 90  90  90  MET MET A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  PRO 95  95  95  PRO PRO A . n 
A 1 96  ALA 96  96  96  ALA ALA A . n 
A 1 97  SER 97  97  97  SER SER A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  THR 99  99  99  THR THR A . n 
A 1 100 ASN 100 100 100 ASN ASN A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 ASP 102 102 102 ASP ASP A . n 
A 1 103 LYS 103 103 103 LYS LYS A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 PHE 105 105 105 PHE PHE A . n 
A 1 106 ALA 106 106 106 ALA ALA A . n 
A 1 107 VAL 107 107 107 VAL VAL A . n 
A 1 108 TRP 108 108 108 TRP TRP A . n 
A 1 109 LYS 109 109 109 LYS LYS A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 TYR 112 112 112 TYR TYR A . n 
A 1 113 LYS 113 113 113 LYS LYS A . n 
A 1 114 ASP 114 114 114 ASP ASP A . n 
A 1 115 THR 115 115 115 THR THR A . n 
A 1 116 VAL 116 116 116 VAL VAL A . n 
A 1 117 GLN 117 117 117 GLN GLN A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 ARG 119 119 119 ARG ARG A . n 
A 1 120 ARG 120 120 120 ARG ARG A . n 
A 1 121 LYS 121 121 121 LYS LYS A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 PHE 124 124 124 PHE PHE A . n 
A 1 125 PHE 125 125 125 PHE PHE A . n 
A 1 126 THR 126 126 126 THR THR A . n 
A 1 127 TYR 127 127 127 TYR TYR A . n 
A 1 128 SER 128 128 128 SER SER A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 PHE 130 130 130 PHE PHE A . n 
A 1 131 ASP 131 131 131 ASP ASP A . n 
A 1 132 MET 132 132 132 MET MET A . n 
A 1 133 GLU 133 133 133 GLU GLU A . n 
A 1 134 LEU 134 134 134 LEU LEU A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 PHE 136 136 136 PHE PHE A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 VAL 138 138 138 VAL VAL A . n 
A 1 139 THR 139 139 139 THR THR A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 ASN 141 141 141 ASN ASN A . n 
A 1 142 PHE 142 142 142 PHE PHE A . n 
A 1 143 THR 143 143 143 THR THR A . n 
A 1 144 GLU 144 144 144 GLU GLU A . n 
A 1 145 THR 145 145 145 THR THR A . n 
A 1 146 ASN 146 146 146 ASN ASN A . n 
A 1 147 ASN 147 147 147 ASN ASN A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 HIS 149 149 149 HIS HIS A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 ASN 152 152 152 ASN ASN A . n 
A 1 153 GLN 153 153 153 GLN GLN A . n 
A 1 154 VAL 154 154 154 VAL VAL A . n 
A 1 155 TYR 155 155 155 TYR TYR A . n 
A 1 156 GLN 156 156 156 GLN GLN A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 MET 158 158 158 MET MET A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 PRO 161 161 161 PRO PRO A . n 
A 1 162 PRO 162 162 162 PRO PRO A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 PRO 165 165 165 PRO PRO A . n 
A 1 166 VAL 166 166 166 VAL VAL A . n 
A 1 167 PRO 167 167 167 PRO PRO A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 LYS 169 169 169 LYS LYS A . n 
A 1 170 TRP 170 170 170 TRP TRP A . n 
A 1 171 ASP 171 171 171 ASP ASP A . n 
A 1 172 ASP 172 172 172 ASP ASP A . n 
A 1 173 TYR 173 173 173 TYR TYR A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 TRP 175 175 175 TRP TRP A . n 
A 1 176 GLN 176 176 176 GLN GLN A . n 
A 1 177 THR 177 177 177 THR THR A . n 
A 1 178 SER 178 178 178 SER SER A . n 
A 1 179 SER 179 179 179 SER SER A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PRO 181 181 181 PRO PRO A . n 
A 1 182 SER 182 182 182 SER SER A . n 
A 1 183 ILE 183 183 183 ILE ILE A . n 
A 1 184 PHE 184 184 184 PHE PHE A . n 
A 1 185 TYR 185 185 185 TYR TYR A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 TYR 187 187 187 TYR TYR A . n 
A 1 188 GLY 188 188 188 GLY GLY A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 PRO 191 191 191 PRO PRO A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 ARG 193 193 193 ARG ARG A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 PRO 197 197 197 PRO PRO A . n 
A 1 198 TYR 198 198 198 TYR TYR A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
A 1 200 GLY 200 200 200 GLY GLY A . n 
A 1 201 ILE 201 201 201 ILE ILE A . n 
A 1 202 SER 202 202 202 SER SER A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 TYR 205 205 205 TYR TYR A . n 
A 1 206 SER 206 206 206 SER SER A . n 
A 1 207 HIS 207 207 207 HIS HIS A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ASP 210 210 210 ASP ASP A . n 
A 1 211 GLY 211 211 211 GLY GLY A . n 
A 1 212 PHE 212 212 212 PHE PHE A . n 
A 1 213 SER 213 213 213 SER SER A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 VAL 215 215 215 VAL VAL A . n 
A 1 216 PRO 216 216 216 PRO PRO A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 LYS 218 218 218 LYS LYS A . n 
A 1 219 ASP 219 219 219 ASP ASP A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 SER 221 221 221 SER SER A . n 
A 1 222 ALA 222 222 222 ALA ALA A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 LEU 224 224 224 LEU LEU A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 ASP 226 226 226 ASP ASP A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 LEU 228 228 228 LEU LEU A . n 
A 1 229 TYR 229 229 229 TYR TYR A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 ALA 231 231 231 ALA ALA A . n 
A 1 232 ALA 232 232 232 ALA ALA A . n 
A 1 233 SER 233 233 233 SER SER A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ASN 235 235 235 ASN ASN A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 PHE 237 237 237 PHE PHE A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 ILE 239 239 239 ILE ILE A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 VAL 242 242 242 VAL VAL A . n 
A 1 243 ARG 243 243 243 ARG ARG A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 VAL 245 245 245 VAL VAL A . n 
A 1 246 ASN 246 246 246 ASN ASN A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 PRO 248 248 248 PRO PRO A . n 
A 1 249 ASN 249 249 249 ASN ASN A . n 
A 1 250 PRO 250 250 250 PRO PRO A . n 
A 1 251 THR 251 251 251 THR THR A . n 
A 1 252 LYS 252 252 252 LYS LYS A . n 
A 1 253 VAL 253 253 253 VAL VAL A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 LYS 256 256 256 LYS LYS A . n 
A 1 257 ILE 257 257 257 ILE ILE A . n 
A 1 258 ARG 258 258 258 ARG ARG A . n 
A 1 259 VAL 259 259 259 VAL VAL A . n 
A 1 260 TYR 260 260 260 TYR TYR A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 LYS 262 262 262 LYS LYS A . n 
A 1 263 PRO 263 263 263 PRO PRO A . n 
A 1 264 LYS 264 264 264 LYS LYS A . n 
A 1 265 HIS 265 265 265 HIS HIS A . n 
A 1 266 ILE 266 266 266 ILE ILE A . n 
A 1 267 ARG 267 267 267 ARG ARG A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 TRP 269 269 269 TRP TRP A . n 
A 1 270 CYS 270 270 270 CYS CYS A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 ARG 272 272 272 ARG ARG A . n 
A 1 273 PRO 273 273 273 PRO PRO A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 ARG 275 275 275 ARG ARG A . n 
A 1 276 ALA 276 276 276 ALA ALA A . n 
A 1 277 VAL 277 277 277 VAL VAL A . n 
A 1 278 ALA 278 278 278 ALA ALA A . n 
A 1 279 TYR 279 279 279 TYR TYR A . n 
A 1 280 TYR 280 280 280 TYR TYR A . n 
A 1 281 GLY 281 281 281 GLY GLY A . n 
A 1 282 PRO 282 282 282 PRO PRO A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 VAL 284 284 284 VAL VAL A . n 
A 1 285 ASP 285 285 285 ASP ASP A . n 
A 1 286 TYR 286 286 286 TYR TYR A . n 
A 1 287 LYS 287 287 287 LYS LYS A . n 
A 1 288 ASP 288 288 288 ASP ASP A . n 
A 1 289 GLY 289 289 289 GLY GLY A . n 
A 1 290 THR 290 290 290 THR THR A . n 
A 1 291 LEU 291 291 291 LEU LEU A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 LEU 294 294 294 LEU LEU A . n 
A 1 295 SER 295 295 295 SER SER A . n 
A 1 296 THR 296 296 296 THR THR A . n 
A 1 297 LYS 297 297 297 LYS LYS A . n 
A 1 298 ASP 298 298 298 ASP ASP A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 THR 300 300 300 THR THR A . n 
A 1 301 THR 301 301 301 THR THR A . n 
A 1 302 TYR 302 302 302 TYR TYR A . n 
B 2 1   MET 1   1   ?   ?   ?   B . n 
B 2 2   GLY 2   2   ?   ?   ?   B . n 
B 2 3   ALA 3   3   ?   ?   ?   B . n 
B 2 4   GLN 4   4   4   GLN GLN B . n 
B 2 5   VAL 5   5   5   VAL VAL B . n 
B 2 6   SER 6   6   6   SER SER B . n 
B 2 7   SER 7   7   7   SER SER B . n 
B 2 8   GLN 8   8   8   GLN GLN B . n 
B 2 9   LYS 9   9   ?   ?   ?   B . n 
B 2 10  VAL 10  10  ?   ?   ?   B . n 
B 2 11  GLY 11  11  ?   ?   ?   B . n 
B 2 12  ALA 12  12  ?   ?   ?   B . n 
B 2 13  HIS 13  13  ?   ?   ?   B . n 
B 2 14  GLU 14  14  ?   ?   ?   B . n 
B 2 15  ASN 15  15  ?   ?   ?   B . n 
B 2 16  SER 16  16  ?   ?   ?   B . n 
B 2 17  ASN 17  17  ?   ?   ?   B . n 
B 2 18  GLY 18  18  ?   ?   ?   B . n 
B 2 19  ALA 19  19  ?   ?   ?   B . n 
B 2 20  TYR 20  20  ?   ?   ?   B . n 
B 2 21  GLY 21  21  ?   ?   ?   B . n 
B 2 22  GLY 22  22  ?   ?   ?   B . n 
B 2 23  SER 23  23  ?   ?   ?   B . n 
B 2 24  THR 24  24  ?   ?   ?   B . n 
B 2 25  ILE 25  25  ?   ?   ?   B . n 
B 2 26  ASN 26  26  ?   ?   ?   B . n 
B 2 27  TYR 27  27  ?   ?   ?   B . n 
B 2 28  THR 28  28  28  THR THR B . n 
B 2 29  THR 29  29  29  THR THR B . n 
B 2 30  ILE 30  30  30  ILE ILE B . n 
B 2 31  ASN 31  31  31  ASN ASN B . n 
B 2 32  TYR 32  32  32  TYR TYR B . n 
B 2 33  TYR 33  33  33  TYR TYR B . n 
B 2 34  ARG 34  34  34  ARG ARG B . n 
B 2 35  ASP 35  35  35  ASP ASP B . n 
B 2 36  SER 36  36  36  SER SER B . n 
B 2 37  ALA 37  37  37  ALA ALA B . n 
B 2 38  SER 38  38  38  SER SER B . n 
B 2 39  ASN 39  39  39  ASN ASN B . n 
B 2 40  ALA 40  40  40  ALA ALA B . n 
B 2 41  ALA 41  41  41  ALA ALA B . n 
B 2 42  SER 42  42  ?   ?   ?   B . n 
B 2 43  LYS 43  43  ?   ?   ?   B . n 
B 2 44  GLN 44  44  ?   ?   ?   B . n 
B 2 45  ASP 45  45  ?   ?   ?   B . n 
B 2 46  PHE 46  46  ?   ?   ?   B . n 
B 2 47  SER 47  47  ?   ?   ?   B . n 
B 2 48  GLN 48  48  ?   ?   ?   B . n 
B 2 49  ASP 49  49  ?   ?   ?   B . n 
B 2 50  PRO 50  50  ?   ?   ?   B . n 
B 2 51  SER 51  51  ?   ?   ?   B . n 
B 2 52  LYS 52  52  ?   ?   ?   B . n 
B 2 53  PHE 53  53  ?   ?   ?   B . n 
B 2 54  THR 54  54  ?   ?   ?   B . n 
B 2 55  GLU 55  55  ?   ?   ?   B . n 
B 2 56  PRO 56  56  ?   ?   ?   B . n 
B 2 57  ILE 57  57  ?   ?   ?   B . n 
B 2 58  LYS 58  58  ?   ?   ?   B . n 
B 2 59  ASP 59  59  ?   ?   ?   B . n 
B 2 60  VAL 60  60  ?   ?   ?   B . n 
B 2 61  LEU 61  61  ?   ?   ?   B . n 
B 2 62  ILE 62  62  ?   ?   ?   B . n 
B 2 63  LYS 63  63  ?   ?   ?   B . n 
B 2 64  THR 64  64  ?   ?   ?   B . n 
B 2 65  ALA 65  65  ?   ?   ?   B . n 
B 2 66  PRO 66  66  ?   ?   ?   B . n 
B 2 67  MET 67  67  ?   ?   ?   B . n 
B 2 68  LEU 68  68  ?   ?   ?   B . n 
B 2 69  ASN 69  69  ?   ?   ?   B . n 
B 2 70  SER 70  70  ?   ?   ?   B . n 
B 2 71  PRO 71  71  ?   ?   ?   B . n 
B 2 72  ASN 72  72  ?   ?   ?   B . n 
B 2 73  ILE 73  73  ?   ?   ?   B . n 
B 2 74  GLU 74  74  ?   ?   ?   B . n 
B 2 75  ALA 75  75  ?   ?   ?   B . n 
B 2 76  CYS 76  76  ?   ?   ?   B . n 
B 2 77  GLY 77  77  ?   ?   ?   B . n 
B 2 78  TYR 78  78  ?   ?   ?   B . n 
B 2 79  SER 79  79  ?   ?   ?   B . n 
B 2 80  ASP 80  80  80  ASP ASP B . n 
B 2 81  ARG 81  81  81  ARG ARG B . n 
B 2 82  VAL 82  82  82  VAL VAL B . n 
B 2 83  LEU 83  83  83  LEU LEU B . n 
B 2 84  GLN 84  84  84  GLN GLN B . n 
B 2 85  LEU 85  85  85  LEU LEU B . n 
B 2 86  THR 86  86  86  THR THR B . n 
B 2 87  LEU 87  87  87  LEU LEU B . n 
B 2 88  GLY 88  88  88  GLY GLY B . n 
B 2 89  ASN 89  89  89  ASN ASN B . n 
B 2 90  SER 90  90  90  SER SER B . n 
B 2 91  THR 91  91  91  THR THR B . n 
B 2 92  ILE 92  92  92  ILE ILE B . n 
B 2 93  THR 93  93  93  THR THR B . n 
B 2 94  ALA 94  94  94  ALA ALA B . n 
B 2 95  GLN 95  95  95  GLN GLN B . n 
B 2 96  GLU 96  96  96  GLU GLU B . n 
B 2 97  ALA 97  97  97  ALA ALA B . n 
B 2 98  ALA 98  98  98  ALA ALA B . n 
B 2 99  ASN 99  99  99  ASN ASN B . n 
B 2 100 SER 100 100 100 SER SER B . n 
B 2 101 VAL 101 101 101 VAL VAL B . n 
B 2 102 VAL 102 102 102 VAL VAL B . n 
B 2 103 ALA 103 103 103 ALA ALA B . n 
B 2 104 TYR 104 104 104 TYR TYR B . n 
B 2 105 GLY 105 105 105 GLY GLY B . n 
B 2 106 ARG 106 106 106 ARG ARG B . n 
B 2 107 TRP 107 107 107 TRP TRP B . n 
B 2 108 PRO 108 108 108 PRO PRO B . n 
B 2 109 GLU 109 109 109 GLU GLU B . n 
B 2 110 TYR 110 110 110 TYR TYR B . n 
B 2 111 LEU 111 111 111 LEU LEU B . n 
B 2 112 ARG 112 112 112 ARG ARG B . n 
B 2 113 ASP 113 113 113 ASP ASP B . n 
B 2 114 SER 114 114 114 SER SER B . n 
B 2 115 GLU 115 115 115 GLU GLU B . n 
B 2 116 ALA 116 116 116 ALA ALA B . n 
B 2 117 ASN 117 117 117 ASN ASN B . n 
B 2 118 PRO 118 118 118 PRO PRO B . n 
B 2 119 VAL 119 119 119 VAL VAL B . n 
B 2 120 ASP 120 120 120 ASP ASP B . n 
B 2 121 GLN 121 121 121 GLN GLN B . n 
B 2 122 PRO 122 122 122 PRO PRO B . n 
B 2 123 THR 123 123 123 THR THR B . n 
B 2 124 GLU 124 124 124 GLU GLU B . n 
B 2 125 PRO 125 125 125 PRO PRO B . n 
B 2 126 GLU 126 126 126 GLU GLU B . n 
B 2 127 VAL 127 127 127 VAL VAL B . n 
B 2 128 ALA 128 128 128 ALA ALA B . n 
B 2 129 ALA 129 129 129 ALA ALA B . n 
B 2 130 CYS 130 130 130 CYS CYS B . n 
B 2 131 ARG 131 131 131 ARG ARG B . n 
B 2 132 PHE 132 132 132 PHE PHE B . n 
B 2 133 TYR 133 133 133 TYR TYR B . n 
B 2 134 THR 134 134 134 THR THR B . n 
B 2 135 LEU 135 135 135 LEU LEU B . n 
B 2 136 ASP 136 136 136 ASP ASP B . n 
B 2 137 THR 137 137 137 THR THR B . n 
B 2 138 VAL 138 138 138 VAL VAL B . n 
B 2 139 SER 139 139 139 SER SER B . n 
B 2 140 TRP 140 140 140 TRP TRP B . n 
B 2 141 THR 141 141 141 THR THR B . n 
B 2 142 LYS 142 142 142 LYS LYS B . n 
B 2 143 GLU 143 143 143 GLU GLU B . n 
B 2 144 SER 144 144 144 SER SER B . n 
B 2 145 ARG 145 145 145 ARG ARG B . n 
B 2 146 GLY 146 146 146 GLY GLY B . n 
B 2 147 TRP 147 147 147 TRP TRP B . n 
B 2 148 TRP 148 148 148 TRP TRP B . n 
B 2 149 TRP 149 149 149 TRP TRP B . n 
B 2 150 LYS 150 150 150 LYS LYS B . n 
B 2 151 LEU 151 151 151 LEU LEU B . n 
B 2 152 PRO 152 152 152 PRO PRO B . n 
B 2 153 ASP 153 153 153 ASP ASP B . n 
B 2 154 ALA 154 154 154 ALA ALA B . n 
B 2 155 LEU 155 155 155 LEU LEU B . n 
B 2 156 ARG 156 156 156 ARG ARG B . n 
B 2 157 ASP 157 157 157 ASP ASP B . n 
B 2 158 MET 158 158 158 MET MET B . n 
B 2 159 GLY 159 159 159 GLY GLY B . n 
B 2 160 LEU 160 160 160 LEU LEU B . n 
B 2 161 PHE 161 161 161 PHE PHE B . n 
B 2 162 GLY 162 162 162 GLY GLY B . n 
B 2 163 GLN 163 163 163 GLN GLN B . n 
B 2 164 ASN 164 164 164 ASN ASN B . n 
B 2 165 MET 165 165 165 MET MET B . n 
B 2 166 TYR 166 166 166 TYR TYR B . n 
B 2 167 TYR 167 167 167 TYR TYR B . n 
B 2 168 HIS 168 168 168 HIS HIS B . n 
B 2 169 TYR 169 169 169 TYR TYR B . n 
B 2 170 LEU 170 170 170 LEU LEU B . n 
B 2 171 GLY 171 171 171 GLY GLY B . n 
B 2 172 ARG 172 172 172 ARG ARG B . n 
B 2 173 SER 173 173 173 SER SER B . n 
B 2 174 GLY 174 174 174 GLY GLY B . n 
B 2 175 TYR 175 175 175 TYR TYR B . n 
B 2 176 THR 176 176 176 THR THR B . n 
B 2 177 VAL 177 177 177 VAL VAL B . n 
B 2 178 HIS 178 178 178 HIS HIS B . n 
B 2 179 VAL 179 179 179 VAL VAL B . n 
B 2 180 GLN 180 180 180 GLN GLN B . n 
B 2 181 CYS 181 181 181 CYS CYS B . n 
B 2 182 ASN 182 182 182 ASN ASN B . n 
B 2 183 ALA 183 183 183 ALA ALA B . n 
B 2 184 SER 184 184 184 SER SER B . n 
B 2 185 LYS 185 185 185 LYS LYS B . n 
B 2 186 PHE 186 186 186 PHE PHE B . n 
B 2 187 HIS 187 187 187 HIS HIS B . n 
B 2 188 GLN 188 188 188 GLN GLN B . n 
B 2 189 GLY 189 189 189 GLY GLY B . n 
B 2 190 ALA 190 190 190 ALA ALA B . n 
B 2 191 LEU 191 191 191 LEU LEU B . n 
B 2 192 GLY 192 192 192 GLY GLY B . n 
B 2 193 VAL 193 193 193 VAL VAL B . n 
B 2 194 PHE 194 194 194 PHE PHE B . n 
B 2 195 ALA 195 195 195 ALA ALA B . n 
B 2 196 VAL 196 196 196 VAL VAL B . n 
B 2 197 PRO 197 197 197 PRO PRO B . n 
B 2 198 GLU 198 198 198 GLU GLU B . n 
B 2 199 MET 199 199 199 MET MET B . n 
B 2 200 CYS 200 200 200 CYS CYS B . n 
B 2 201 LEU 201 201 201 LEU LEU B . n 
B 2 202 ALA 202 202 202 ALA ALA B . n 
B 2 203 GLY 203 203 203 GLY GLY B . n 
B 2 204 ASP 204 204 204 ASP ASP B . n 
B 2 205 SER 205 205 205 SER SER B . n 
B 2 206 ASN 206 206 206 ASN ASN B . n 
B 2 207 THR 207 207 207 THR THR B . n 
B 2 208 THR 208 208 208 THR THR B . n 
B 2 209 THR 209 209 209 THR THR B . n 
B 2 210 MET 210 210 210 MET MET B . n 
B 2 211 HIS 211 211 211 HIS HIS B . n 
B 2 212 THR 212 212 212 THR THR B . n 
B 2 213 SER 213 213 213 SER SER B . n 
B 2 214 TYR 214 214 214 TYR TYR B . n 
B 2 215 GLN 215 215 215 GLN GLN B . n 
B 2 216 ASN 216 216 216 ASN ASN B . n 
B 2 217 ALA 217 217 217 ALA ALA B . n 
B 2 218 ASN 218 218 218 ASN ASN B . n 
B 2 219 PRO 219 219 219 PRO PRO B . n 
B 2 220 GLY 220 220 220 GLY GLY B . n 
B 2 221 GLU 221 221 221 GLU GLU B . n 
B 2 222 LYS 222 222 222 LYS LYS B . n 
B 2 223 GLY 223 223 223 GLY GLY B . n 
B 2 224 GLY 224 224 224 GLY GLY B . n 
B 2 225 THR 225 225 225 THR THR B . n 
B 2 226 PHE 226 226 226 PHE PHE B . n 
B 2 227 THR 227 227 227 THR THR B . n 
B 2 228 GLY 228 228 228 GLY GLY B . n 
B 2 229 THR 229 229 229 THR THR B . n 
B 2 230 PHE 230 230 230 PHE PHE B . n 
B 2 231 THR 231 231 231 THR THR B . n 
B 2 232 PRO 232 232 232 PRO PRO B . n 
B 2 233 ASP 233 233 233 ASP ASP B . n 
B 2 234 ASN 234 234 234 ASN ASN B . n 
B 2 235 ASN 235 235 235 ASN ASN B . n 
B 2 236 GLN 236 236 236 GLN GLN B . n 
B 2 237 THR 237 237 237 THR THR B . n 
B 2 238 SER 238 238 238 SER SER B . n 
B 2 239 PRO 239 239 239 PRO PRO B . n 
B 2 240 ALA 240 240 240 ALA ALA B . n 
B 2 241 ARG 241 241 241 ARG ARG B . n 
B 2 242 ARG 242 242 242 ARG ARG B . n 
B 2 243 PHE 243 243 243 PHE PHE B . n 
B 2 244 CYS 244 244 244 CYS CYS B . n 
B 2 245 PRO 245 245 245 PRO PRO B . n 
B 2 246 VAL 246 246 246 VAL VAL B . n 
B 2 247 ASP 247 247 247 ASP ASP B . n 
B 2 248 TYR 248 248 248 TYR TYR B . n 
B 2 249 LEU 249 249 249 LEU LEU B . n 
B 2 250 LEU 250 250 250 LEU LEU B . n 
B 2 251 GLY 251 251 251 GLY GLY B . n 
B 2 252 ASN 252 252 252 ASN ASN B . n 
B 2 253 GLY 253 253 253 GLY GLY B . n 
B 2 254 THR 254 254 254 THR THR B . n 
B 2 255 LEU 255 255 255 LEU LEU B . n 
B 2 256 LEU 256 256 256 LEU LEU B . n 
B 2 257 GLY 257 257 257 GLY GLY B . n 
B 2 258 ASN 258 258 258 ASN ASN B . n 
B 2 259 ALA 259 259 259 ALA ALA B . n 
B 2 260 PHE 260 260 260 PHE PHE B . n 
B 2 261 VAL 261 261 261 VAL VAL B . n 
B 2 262 PHE 262 262 262 PHE PHE B . n 
B 2 263 PRO 263 263 263 PRO PRO B . n 
B 2 264 HIS 264 264 264 HIS HIS B . n 
B 2 265 GLN 265 265 265 GLN GLN B . n 
B 2 266 ILE 266 266 266 ILE ILE B . n 
B 2 267 ILE 267 267 267 ILE ILE B . n 
B 2 268 ASN 268 268 268 ASN ASN B . n 
B 2 269 LEU 269 269 269 LEU LEU B . n 
B 2 270 ARG 270 270 270 ARG ARG B . n 
B 2 271 THR 271 271 271 THR THR B . n 
B 2 272 ASN 272 272 272 ASN ASN B . n 
B 2 273 ASN 273 273 273 ASN ASN B . n 
B 2 274 CYS 274 274 274 CYS CYS B . n 
B 2 275 ALA 275 275 275 ALA ALA B . n 
B 2 276 THR 276 276 276 THR THR B . n 
B 2 277 LEU 277 277 277 LEU LEU B . n 
B 2 278 VAL 278 278 278 VAL VAL B . n 
B 2 279 LEU 279 279 279 LEU LEU B . n 
B 2 280 PRO 280 280 280 PRO PRO B . n 
B 2 281 TYR 281 281 281 TYR TYR B . n 
B 2 282 VAL 282 282 282 VAL VAL B . n 
B 2 283 ASN 283 283 283 ASN ASN B . n 
B 2 284 SER 284 284 284 SER SER B . n 
B 2 285 LEU 285 285 285 LEU LEU B . n 
B 2 286 SER 286 286 286 SER SER B . n 
B 2 287 ILE 287 287 287 ILE ILE B . n 
B 2 288 ASP 288 288 288 ASP ASP B . n 
B 2 289 SER 289 289 289 SER SER B . n 
B 2 290 MET 290 290 290 MET MET B . n 
B 2 291 VAL 291 291 291 VAL VAL B . n 
B 2 292 LYS 292 292 292 LYS LYS B . n 
B 2 293 HIS 293 293 293 HIS HIS B . n 
B 2 294 ASN 294 294 294 ASN ASN B . n 
B 2 295 ASN 295 295 295 ASN ASN B . n 
B 2 296 TRP 296 296 296 TRP TRP B . n 
B 2 297 GLY 297 297 297 GLY GLY B . n 
B 2 298 ILE 298 298 298 ILE ILE B . n 
B 2 299 ALA 299 299 299 ALA ALA B . n 
B 2 300 ILE 300 300 300 ILE ILE B . n 
B 2 301 LEU 301 301 301 LEU LEU B . n 
B 2 302 PRO 302 302 302 PRO PRO B . n 
B 2 303 LEU 303 303 303 LEU LEU B . n 
B 2 304 ALA 304 304 304 ALA ALA B . n 
B 2 305 PRO 305 305 305 PRO PRO B . n 
B 2 306 LEU 306 306 306 LEU LEU B . n 
B 2 307 ASN 307 307 307 ASN ASN B . n 
B 2 308 PHE 308 308 308 PHE PHE B . n 
B 2 309 ALA 309 309 309 ALA ALA B . n 
B 2 310 SER 310 310 310 SER SER B . n 
B 2 311 GLU 311 311 311 GLU GLU B . n 
B 2 312 SER 312 312 312 SER SER B . n 
B 2 313 SER 313 313 313 SER SER B . n 
B 2 314 PRO 314 314 314 PRO PRO B . n 
B 2 315 GLU 315 315 315 GLU GLU B . n 
B 2 316 ILE 316 316 316 ILE ILE B . n 
B 2 317 PRO 317 317 317 PRO PRO B . n 
B 2 318 ILE 318 318 318 ILE ILE B . n 
B 2 319 THR 319 319 319 THR THR B . n 
B 2 320 LEU 320 320 320 LEU LEU B . n 
B 2 321 THR 321 321 321 THR THR B . n 
B 2 322 ILE 322 322 322 ILE ILE B . n 
B 2 323 ALA 323 323 323 ALA ALA B . n 
B 2 324 PRO 324 324 324 PRO PRO B . n 
B 2 325 MET 325 325 325 MET MET B . n 
B 2 326 CYS 326 326 326 CYS CYS B . n 
B 2 327 CYS 327 327 327 CYS CYS B . n 
B 2 328 GLU 328 328 328 GLU GLU B . n 
B 2 329 PHE 329 329 329 PHE PHE B . n 
B 2 330 ASN 330 330 330 ASN ASN B . n 
B 2 331 GLY 331 331 331 GLY GLY B . n 
B 2 332 LEU 332 332 332 LEU LEU B . n 
B 2 333 ARG 333 333 333 ARG ARG B . n 
B 2 334 ASN 334 334 334 ASN ASN B . n 
B 2 335 ILE 335 335 335 ILE ILE B . n 
B 2 336 THR 336 336 336 THR THR B . n 
B 2 337 LEU 337 337 337 LEU LEU B . n 
B 2 338 PRO 338 338 338 PRO PRO B . n 
B 2 339 ARG 339 339 339 ARG ARG B . n 
B 2 340 LEU 340 340 340 LEU LEU B . n 
B 2 341 GLN 341 341 341 GLN GLN B . n 
C 3 1   GLY 1   1   1   GLY GLY C . n 
C 3 2   LEU 2   2   2   LEU LEU C . n 
C 3 3   PRO 3   3   3   PRO PRO C . n 
C 3 4   VAL 4   4   4   VAL VAL C . n 
C 3 5   MET 5   5   5   MET MET C . n 
C 3 6   ASN 6   6   6   ASN ASN C . n 
C 3 7   THR 7   7   7   THR THR C . n 
C 3 8   PRO 8   8   8   PRO PRO C . n 
C 3 9   GLY 9   9   9   GLY GLY C . n 
C 3 10  SER 10  10  10  SER SER C . n 
C 3 11  ASN 11  11  11  ASN ASN C . n 
C 3 12  GLN 12  12  12  GLN GLN C . n 
C 3 13  TYR 13  13  13  TYR TYR C . n 
C 3 14  LEU 14  14  14  LEU LEU C . n 
C 3 15  THR 15  15  15  THR THR C . n 
C 3 16  ALA 16  16  16  ALA ALA C . n 
C 3 17  ASP 17  17  17  ASP ASP C . n 
C 3 18  ASN 18  18  18  ASN ASN C . n 
C 3 19  PHE 19  19  19  PHE PHE C . n 
C 3 20  GLN 20  20  20  GLN GLN C . n 
C 3 21  SER 21  21  21  SER SER C . n 
C 3 22  PRO 22  22  22  PRO PRO C . n 
C 3 23  CYS 23  23  23  CYS CYS C . n 
C 3 24  ALA 24  24  24  ALA ALA C . n 
C 3 25  LEU 25  25  25  LEU LEU C . n 
C 3 26  PRO 26  26  26  PRO PRO C . n 
C 3 27  GLU 27  27  27  GLU GLU C . n 
C 3 28  PHE 28  28  28  PHE PHE C . n 
C 3 29  ASP 29  29  29  ASP ASP C . n 
C 3 30  VAL 30  30  30  VAL VAL C . n 
C 3 31  THR 31  31  31  THR THR C . n 
C 3 32  PRO 32  32  32  PRO PRO C . n 
C 3 33  PRO 33  33  33  PRO PRO C . n 
C 3 34  ILE 34  34  34  ILE ILE C . n 
C 3 35  ASP 35  35  35  ASP ASP C . n 
C 3 36  ILE 36  36  36  ILE ILE C . n 
C 3 37  PRO 37  37  37  PRO PRO C . n 
C 3 38  GLY 38  38  38  GLY GLY C . n 
C 3 39  GLU 39  39  39  GLU GLU C . n 
C 3 40  VAL 40  40  40  VAL VAL C . n 
C 3 41  LYS 41  41  41  LYS LYS C . n 
C 3 42  ASN 42  42  42  ASN ASN C . n 
C 3 43  MET 43  43  43  MET MET C . n 
C 3 44  MET 44  44  44  MET MET C . n 
C 3 45  GLU 45  45  45  GLU GLU C . n 
C 3 46  LEU 46  46  46  LEU LEU C . n 
C 3 47  ALA 47  47  47  ALA ALA C . n 
C 3 48  GLU 48  48  48  GLU GLU C . n 
C 3 49  ILE 49  49  49  ILE ILE C . n 
C 3 50  ASP 50  50  50  ASP ASP C . n 
C 3 51  THR 51  51  51  THR THR C . n 
C 3 52  MET 52  52  52  MET MET C . n 
C 3 53  ILE 53  53  53  ILE ILE C . n 
C 3 54  PRO 54  54  54  PRO PRO C . n 
C 3 55  PHE 55  55  55  PHE PHE C . n 
C 3 56  ASP 56  56  56  ASP ASP C . n 
C 3 57  LEU 57  57  57  LEU LEU C . n 
C 3 58  SER 58  58  58  SER SER C . n 
C 3 59  ALA 59  59  59  ALA ALA C . n 
C 3 60  THR 60  60  60  THR THR C . n 
C 3 61  LYS 61  61  61  LYS LYS C . n 
C 3 62  LYS 62  62  62  LYS LYS C . n 
C 3 63  ASN 63  63  63  ASN ASN C . n 
C 3 64  THR 64  64  64  THR THR C . n 
C 3 65  MET 65  65  65  MET MET C . n 
C 3 66  GLU 66  66  66  GLU GLU C . n 
C 3 67  MET 67  67  67  MET MET C . n 
C 3 68  TYR 68  68  68  TYR TYR C . n 
C 3 69  ARG 69  69  69  ARG ARG C . n 
C 3 70  VAL 70  70  70  VAL VAL C . n 
C 3 71  ARG 71  71  71  ARG ARG C . n 
C 3 72  LEU 72  72  72  LEU LEU C . n 
C 3 73  SER 73  73  73  SER SER C . n 
C 3 74  ASP 74  74  74  ASP ASP C . n 
C 3 75  LYS 75  75  75  LYS LYS C . n 
C 3 76  PRO 76  76  76  PRO PRO C . n 
C 3 77  HIS 77  77  77  HIS HIS C . n 
C 3 78  THR 78  78  78  THR THR C . n 
C 3 79  ASP 79  79  79  ASP ASP C . n 
C 3 80  ASP 80  80  80  ASP ASP C . n 
C 3 81  PRO 81  81  81  PRO PRO C . n 
C 3 82  ILE 82  82  82  ILE ILE C . n 
C 3 83  LEU 83  83  83  LEU LEU C . n 
C 3 84  CYS 84  84  84  CYS CYS C . n 
C 3 85  LEU 85  85  85  LEU LEU C . n 
C 3 86  SER 86  86  86  SER SER C . n 
C 3 87  LEU 87  87  87  LEU LEU C . n 
C 3 88  SER 88  88  88  SER SER C . n 
C 3 89  PRO 89  89  89  PRO PRO C . n 
C 3 90  ALA 90  90  90  ALA ALA C . n 
C 3 91  SER 91  91  91  SER SER C . n 
C 3 92  ASP 92  92  92  ASP ASP C . n 
C 3 93  PRO 93  93  93  PRO PRO C . n 
C 3 94  ARG 94  94  94  ARG ARG C . n 
C 3 95  LEU 95  95  95  LEU LEU C . n 
C 3 96  SER 96  96  96  SER SER C . n 
C 3 97  HIS 97  97  97  HIS HIS C . n 
C 3 98  THR 98  98  98  THR THR C . n 
C 3 99  MET 99  99  99  MET MET C . n 
C 3 100 LEU 100 100 100 LEU LEU C . n 
C 3 101 GLY 101 101 101 GLY GLY C . n 
C 3 102 GLU 102 102 102 GLU GLU C . n 
C 3 103 ILE 103 103 103 ILE ILE C . n 
C 3 104 LEU 104 104 104 LEU LEU C . n 
C 3 105 ASN 105 105 105 ASN ASN C . n 
C 3 106 TYR 106 106 106 TYR TYR C . n 
C 3 107 TYR 107 107 107 TYR TYR C . n 
C 3 108 THR 108 108 108 THR THR C . n 
C 3 109 HIS 109 109 109 HIS HIS C . n 
C 3 110 TRP 110 110 110 TRP TRP C . n 
C 3 111 ALA 111 111 111 ALA ALA C . n 
C 3 112 GLY 112 112 112 GLY GLY C . n 
C 3 113 SER 113 113 113 SER SER C . n 
C 3 114 LEU 114 114 114 LEU LEU C . n 
C 3 115 LYS 115 115 115 LYS LYS C . n 
C 3 116 PHE 116 116 116 PHE PHE C . n 
C 3 117 THR 117 117 117 THR THR C . n 
C 3 118 PHE 118 118 118 PHE PHE C . n 
C 3 119 MET 119 119 119 MET MET C . n 
C 3 120 PHE 120 120 120 PHE PHE C . n 
C 3 121 CYS 121 121 121 CYS CYS C . n 
C 3 122 GLY 122 122 122 GLY GLY C . n 
C 3 123 SER 123 123 123 SER SER C . n 
C 3 124 MET 124 124 124 MET MET C . n 
C 3 125 MET 125 125 125 MET MET C . n 
C 3 126 ALA 126 126 126 ALA ALA C . n 
C 3 127 THR 127 127 127 THR THR C . n 
C 3 128 GLY 128 128 128 GLY GLY C . n 
C 3 129 LYS 129 129 129 LYS LYS C . n 
C 3 130 LEU 130 130 130 LEU LEU C . n 
C 3 131 LEU 131 131 131 LEU LEU C . n 
C 3 132 VAL 132 132 132 VAL VAL C . n 
C 3 133 SER 133 133 133 SER SER C . n 
C 3 134 TYR 134 134 134 TYR TYR C . n 
C 3 135 ALA 135 135 135 ALA ALA C . n 
C 3 136 PRO 136 136 136 PRO PRO C . n 
C 3 137 PRO 137 137 137 PRO PRO C . n 
C 3 138 GLY 138 138 138 GLY GLY C . n 
C 3 139 ALA 139 139 139 ALA ALA C . n 
C 3 140 ASP 140 140 140 ASP ASP C . n 
C 3 141 PRO 141 141 141 PRO PRO C . n 
C 3 142 PRO 142 142 142 PRO PRO C . n 
C 3 143 LYS 143 143 143 LYS LYS C . n 
C 3 144 LYS 144 144 144 LYS LYS C . n 
C 3 145 ARG 145 145 145 ARG ARG C . n 
C 3 146 LYS 146 146 146 LYS LYS C . n 
C 3 147 GLU 147 147 147 GLU GLU C . n 
C 3 148 ALA 148 148 148 ALA ALA C . n 
C 3 149 MET 149 149 149 MET MET C . n 
C 3 150 LEU 150 150 150 LEU LEU C . n 
C 3 151 GLY 151 151 151 GLY GLY C . n 
C 3 152 THR 152 152 152 THR THR C . n 
C 3 153 HIS 153 153 153 HIS HIS C . n 
C 3 154 VAL 154 154 154 VAL VAL C . n 
C 3 155 ILE 155 155 155 ILE ILE C . n 
C 3 156 TRP 156 156 156 TRP TRP C . n 
C 3 157 ASP 157 157 157 ASP ASP C . n 
C 3 158 ILE 158 158 158 ILE ILE C . n 
C 3 159 GLY 159 159 159 GLY GLY C . n 
C 3 160 LEU 160 160 160 LEU LEU C . n 
C 3 161 GLN 161 161 161 GLN GLN C . n 
C 3 162 SER 162 162 162 SER SER C . n 
C 3 163 SER 163 163 163 SER SER C . n 
C 3 164 CYS 164 164 164 CYS CYS C . n 
C 3 165 THR 165 165 165 THR THR C . n 
C 3 166 MET 166 166 166 MET MET C . n 
C 3 167 VAL 167 167 167 VAL VAL C . n 
C 3 168 VAL 168 168 168 VAL VAL C . n 
C 3 169 PRO 169 169 169 PRO PRO C . n 
C 3 170 TRP 170 170 170 TRP TRP C . n 
C 3 171 ILE 171 171 171 ILE ILE C . n 
C 3 172 SER 172 172 172 SER SER C . n 
C 3 173 ASN 173 173 173 ASN ASN C . n 
C 3 174 THR 174 174 174 THR THR C . n 
C 3 175 THR 175 175 175 THR THR C . n 
C 3 176 TYR 176 176 176 TYR TYR C . n 
C 3 177 ARG 177 177 177 ARG ARG C . n 
C 3 178 LEU 178 178 178 LEU LEU C . n 
C 3 179 THR 179 179 179 THR THR C . n 
C 3 180 ILE 180 180 180 ILE ILE C . n 
C 3 181 ASP 181 181 181 ASP ASP C . n 
C 3 182 ASP 182 182 182 ASP ASP C . n 
C 3 183 SER 183 183 183 SER SER C . n 
C 3 184 PHE 184 184 184 PHE PHE C . n 
C 3 185 THR 185 185 185 THR THR C . n 
C 3 186 GLU 186 186 186 GLU GLU C . n 
C 3 187 GLY 187 187 187 GLY GLY C . n 
C 3 188 GLY 188 188 188 GLY GLY C . n 
C 3 189 TYR 189 189 189 TYR TYR C . n 
C 3 190 ILE 190 190 190 ILE ILE C . n 
C 3 191 SER 191 191 191 SER SER C . n 
C 3 192 VAL 192 192 192 VAL VAL C . n 
C 3 193 PHE 193 193 193 PHE PHE C . n 
C 3 194 TYR 194 194 194 TYR TYR C . n 
C 3 195 GLN 195 195 195 GLN GLN C . n 
C 3 196 THR 196 196 196 THR THR C . n 
C 3 197 ARG 197 197 197 ARG ARG C . n 
C 3 198 ILE 198 198 198 ILE ILE C . n 
C 3 199 VAL 199 199 199 VAL VAL C . n 
C 3 200 VAL 200 200 200 VAL VAL C . n 
C 3 201 PRO 201 201 201 PRO PRO C . n 
C 3 202 LEU 202 202 202 LEU LEU C . n 
C 3 203 SER 203 203 203 SER SER C . n 
C 3 204 THR 204 204 204 THR THR C . n 
C 3 205 PRO 205 205 205 PRO PRO C . n 
C 3 206 ARG 206 206 206 ARG ARG C . n 
C 3 207 GLU 207 207 207 GLU GLU C . n 
C 3 208 MET 208 208 208 MET MET C . n 
C 3 209 ASP 209 209 209 ASP ASP C . n 
C 3 210 ILE 210 210 210 ILE ILE C . n 
C 3 211 LEU 211 211 211 LEU LEU C . n 
C 3 212 GLY 212 212 212 GLY GLY C . n 
C 3 213 PHE 213 213 213 PHE PHE C . n 
C 3 214 VAL 214 214 214 VAL VAL C . n 
C 3 215 SER 215 215 215 SER SER C . n 
C 3 216 ALA 216 216 216 ALA ALA C . n 
C 3 217 CYS 217 217 217 CYS CYS C . n 
C 3 218 ASN 218 218 218 ASN ASN C . n 
C 3 219 ASP 219 219 219 ASP ASP C . n 
C 3 220 PHE 220 220 220 PHE PHE C . n 
C 3 221 SER 221 221 221 SER SER C . n 
C 3 222 VAL 222 222 222 VAL VAL C . n 
C 3 223 ARG 223 223 223 ARG ARG C . n 
C 3 224 LEU 224 224 224 LEU LEU C . n 
C 3 225 LEU 225 225 225 LEU LEU C . n 
C 3 226 ARG 226 226 226 ARG ARG C . n 
C 3 227 ASP 227 227 227 ASP ASP C . n 
C 3 228 THR 228 228 228 THR THR C . n 
C 3 229 THR 229 229 229 THR THR C . n 
C 3 230 HIS 230 230 230 HIS HIS C . n 
C 3 231 ILE 231 231 231 ILE ILE C . n 
C 3 232 GLU 232 232 232 GLU GLU C . n 
C 3 233 GLN 233 233 233 GLN GLN C . n 
C 3 234 LYS 234 234 234 LYS LYS C . n 
C 3 235 ALA 235 235 235 ALA ALA C . n 
C 3 236 LEU 236 236 ?   ?   ?   C . n 
C 3 237 ALA 237 237 ?   ?   ?   C . n 
C 3 238 GLN 238 238 ?   ?   ?   C . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        PLM 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   PLM 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         D 
_pdbx_nonpoly_scheme.entity_id       4 
_pdbx_nonpoly_scheme.mon_id          PLM 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     401 
_pdbx_nonpoly_scheme.auth_seq_num    401 
_pdbx_nonpoly_scheme.pdb_mon_id      PLM 
_pdbx_nonpoly_scheme.auth_mon_id     PLM 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9EYY 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9EYY 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9EYY 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9EYY 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            . 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003  ? 38322 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.495  ? 52302 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 10.551 ? 13908 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.043  ? 5868  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004  ? 6750  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9EYY 
_struct.title                        
'Poliovirus type 1 (strain Mahoney) native conformation stabilised virus-like particle (PV1 SC6b) from a yeast expression system.' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9EYY 
_struct_keywords.text            'Capsid protein, virus-like particle, vaccine, VIRUS LIKE PARTICLE' 
_struct_keywords.pdbx_keywords   'VIRUS LIKE PARTICLE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP POLG_POL1M P03300 ? 1 
;GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESF
FARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYV
PPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGIL
AVRVVNDHNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY
;
580 
2 UNP POLG_POL1M P03300 ? 2 
;GAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSDR
VLQLTLGNSTITTQEAANSVVAYGRWPEYLRDSEANPVDQPTEPDVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGLF
GQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPAR
RFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITLT
IAPMCCEFNGLRNITLPRLQ
;
2   
3 UNP POLG_POL1M P03300 ? 3 
;GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDD
PILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFLFCGFMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRQTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQ
;
342 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9EYY A 1 ? 302 ? P03300 580 ? 881 ? 1 302 
2 2 9EYY B 2 ? 341 ? P03300 2   ? 341 ? 2 341 
3 3 9EYY C 1 ? 238 ? P03300 342 ? 579 ? 1 238 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9EYY PRO A 248 ? UNP P03300 HIS 827 'engineered mutation'   248 1 
2 9EYY MET B 1   ? UNP P03300 ?   ?   'initiating methionine' 1   2 
2 9EYY GLY B 18  ? UNP P03300 ARG 18  'engineered mutation'   18  3 
2 9EYY ALA B 94  ? UNP P03300 THR 94  'engineered mutation'   94  4 
2 9EYY GLU B 126 ? UNP P03300 ASP 126 'engineered mutation'   126 5 
3 9EYY MET C 119 ? UNP P03300 LEU 460 'engineered mutation'   119 6 
3 9EYY SER C 123 ? UNP P03300 PHE 464 variant                 123 7 
3 9EYY LEU C 178 ? UNP P03300 GLN 519 'engineered mutation'   178 8 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   180-meric 
_pdbx_struct_assembly.oligomeric_count     180 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   
;1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60
;
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1  'identity operation'       1_555 x,y,z 1.000000  0.000000  0.000000  0.00000    0.000000  1.000000  0.000000  0.00000    
0.000000  0.000000  1.000000  0.00000    
2  'point symmetry operation' ?     ?     -0.809017 -0.500000 0.309017  419.14714  -0.500000 0.309017  -0.809017 419.20068  
0.309017  -0.809017 -0.500000 419.23377  
3  'point symmetry operation' ?     ?     0.000000  1.000000  0.000000  -0.06900   0.000000  0.000000  -1.000000 419.22890  
-1.000000 0.000000  0.000000  419.15990  
4  'point symmetry operation' ?     ?     0.809017  -0.500000 -0.309017 209.60756  -0.500000 -0.309017 -0.809017 548.75970  
0.309017  0.809017  -0.500000 80.04385   
5  'point symmetry operation' ?     ?     0.500000  0.309017  -0.809017 209.56978  -0.309017 -0.809017 -0.500000 548.78305  
-0.809017 0.500000  -0.309017 339.09103  
6  'point symmetry operation' ?     ?     -0.309017 -0.809017 -0.500000 548.71405  -0.809017 0.500000  -0.309017 339.12393  
0.500000  0.309017  -0.809017 209.60588  
7  'point symmetry operation' ?     ?     -0.809017 0.500000  -0.309017 339.05493  0.500000  0.309017  -0.809017 209.63878  
-0.309017 -0.809017 -0.500000 548.75015  
8  'point symmetry operation' ?     ?     -0.809017 -0.500000 -0.309017 548.68583  0.500000  -0.309017 -0.809017 339.19780  
0.309017  -0.809017 0.500000  209.63577  
9  'point symmetry operation' ?     ?     -0.309017 0.809017  -0.500000 209.52413  -0.809017 -0.500000 -0.309017 548.75483  
-0.500000 0.309017  0.809017  80.03110   
10 'point symmetry operation' ?     ?     0.500000  -0.309017 -0.809017 339.12880  -0.309017 0.809017  -0.500000 209.59313  
0.809017  0.500000  0.309017  -129.52593 
11 'point symmetry operation' ?     ?     0.000000  0.000000  -1.000000 419.15990  -1.000000 0.000000  0.000000  419.19280  
0.000000  1.000000  0.000000  -0.03290   
12 'point symmetry operation' ?     ?     -0.500000 -0.309017 -0.809017 548.69070  0.309017  0.809017  -0.500000 80.07675   
0.809017  -0.500000 -0.309017 209.64366  
13 'point symmetry operation' ?     ?     -0.500000 0.309017  -0.809017 419.13168  0.309017  -0.809017 -0.500000 419.26667  
-0.809017 -0.500000 0.309017  419.18324  
14 'point symmetry operation' ?     ?     -0.309017 -0.809017 -0.500000 548.71405  0.809017  -0.500000 0.309017  80.13787   
-0.500000 -0.309017 0.809017  209.59012  
15 'point symmetry operation' ?     ?     -0.809017 0.500000  -0.309017 339.05493  -0.500000 -0.309017 0.809017  209.62302  
0.309017  0.809017  0.500000  -129.55415 
16 'point symmetry operation' ?     ?     0.500000  0.309017  -0.809017 209.56978  0.309017  0.809017  0.500000  -129.52125 
0.809017  -0.500000 0.309017  80.10497   
17 'point symmetry operation' ?     ?     -0.500000 0.309017  -0.809017 419.13168  -0.309017 0.809017  0.500000  -0.00487   
0.809017  0.500000  -0.309017 0.01276    
18 'point symmetry operation' ?     ?     0.000000  0.000000  -1.000000 419.15990  1.000000  0.000000  0.000000  0.06900    
0.000000  -1.000000 0.000000  419.22890  
19 'point symmetry operation' ?     ?     -0.500000 -0.309017 -0.809017 548.69070  -0.309017 -0.809017 0.500000  339.18505  
-0.809017 0.500000  0.309017  209.55234  
20 'point symmetry operation' ?     ?     0.000000  -1.000000 0.000000  419.19280  0.000000  0.000000  1.000000  0.03290    
-1.000000 0.000000  0.000000  419.15990  
21 'point symmetry operation' ?     ?     -0.809017 0.500000  0.309017  209.51624  0.500000  0.309017  0.809017  -129.49790 
0.309017  0.809017  -0.500000 80.04385   
22 'point symmetry operation' ?     ?     0.809017  0.500000  -0.309017 -0.02334   0.500000  -0.309017 0.809017  0.06112    
0.309017  -0.809017 -0.500000 419.23377  
23 'point symmetry operation' ?     ?     -0.309017 0.809017  -0.500000 209.52413  0.809017  0.500000  0.309017  -129.49303 
0.500000  -0.309017 -0.809017 339.16490  
24 'point symmetry operation' ?     ?     0.500000  -0.309017 -0.809017 339.12880  0.309017  -0.809017 0.500000  209.66867  
-0.809017 -0.500000 -0.309017 548.72193  
25 'point symmetry operation' ?     ?     -0.809017 -0.500000 -0.309017 548.68583  -0.500000 0.309017  0.809017  80.06400   
-0.309017 0.809017  -0.500000 209.56023  
26 'point symmetry operation' ?     ?     -0.309017 -0.809017 0.500000  339.11605  -0.809017 0.500000  0.309017  209.58524  
-0.500000 -0.309017 -0.809017 548.72680  
27 'point symmetry operation' ?     ?     -0.309017 0.809017  0.500000  -0.07387   0.809017  0.500000  -0.309017 0.04566    
-0.500000 0.309017  -0.809017 419.16778  
28 'point symmetry operation' ?     ?     1.000000  0.000000  0.000000  0.00000    0.000000  -1.000000 0.000000  419.26180  
0.000000  0.000000  -1.000000 419.19600  
29 'point symmetry operation' ?     ?     0.309017  0.809017  -0.500000 80.00775   0.809017  -0.500000 -0.309017 209.67656  
-0.500000 -0.309017 -0.809017 548.72680  
30 'point symmetry operation' ?     ?     0.309017  -0.809017 -0.500000 419.19767  -0.809017 -0.500000 0.309017  419.21614  
-0.500000 0.309017  -0.809017 419.16778  
31 'point symmetry operation' ?     ?     -1.000000 0.000000  0.000000  419.12380  0.000000  1.000000  0.000000  0.00000    
0.000000  0.000000  -1.000000 419.19600  
32 'point symmetry operation' ?     ?     0.809017  0.500000  -0.309017 -0.02334   -0.500000 0.309017  -0.809017 419.20068  
-0.309017 0.809017  0.500000  -0.03777   
33 'point symmetry operation' ?     ?     0.000000  -1.000000 0.000000  419.19280  0.000000  0.000000  -1.000000 419.22890  
1.000000  0.000000  0.000000  0.03610    
34 'point symmetry operation' ?     ?     -0.809017 0.500000  0.309017  209.51624  -0.500000 -0.309017 -0.809017 548.75970  
-0.309017 -0.809017 0.500000  339.15215  
35 'point symmetry operation' ?     ?     -0.500000 -0.309017 0.809017  209.55402  -0.309017 -0.809017 -0.500000 548.78305  
0.809017  -0.500000 0.309017  80.10497   
36 'point symmetry operation' ?     ?     0.309017  0.809017  0.500000  -129.59025 -0.809017 0.500000  -0.309017 339.12393  
-0.500000 -0.309017 0.809017  209.59012  
37 'point symmetry operation' ?     ?     0.809017  -0.500000 0.309017  80.06887   0.500000  0.309017  -0.809017 209.63878  
0.309017  0.809017  0.500000  -129.55415 
38 'point symmetry operation' ?     ?     0.809017  0.500000  0.309017  -129.56203 0.500000  -0.309017 -0.809017 339.19780  
-0.309017 0.809017  -0.500000 209.56023  
39 'point symmetry operation' ?     ?     0.309017  -0.809017 0.500000  209.59967  -0.809017 -0.500000 -0.309017 548.75483  
0.500000  -0.309017 -0.809017 339.16490  
40 'point symmetry operation' ?     ?     -0.500000 0.309017  0.809017  79.99500   -0.309017 0.809017  -0.500000 209.59313  
-0.809017 -0.500000 -0.309017 548.72193  
41 'point symmetry operation' ?     ?     0.000000  0.000000  1.000000  -0.03610   -1.000000 0.000000  0.000000  419.19280  
0.000000  -1.000000 0.000000  419.22890  
42 'point symmetry operation' ?     ?     0.500000  0.309017  0.809017  -129.56690 0.309017  0.809017  -0.500000 80.07675   
-0.809017 0.500000  0.309017  209.55234  
43 'point symmetry operation' ?     ?     0.500000  -0.309017 0.809017  -0.00788   0.309017  -0.809017 -0.500000 419.26667  
0.809017  0.500000  -0.309017 0.01276    
44 'point symmetry operation' ?     ?     0.309017  0.809017  0.500000  -129.59025 0.809017  -0.500000 0.309017  80.13787   
0.500000  0.309017  -0.809017 209.60588  
45 'point symmetry operation' ?     ?     0.809017  -0.500000 0.309017  80.06887   -0.500000 -0.309017 0.809017  209.62302  
-0.309017 -0.809017 -0.500000 548.75015  
46 'point symmetry operation' ?     ?     -0.500000 -0.309017 0.809017  209.55402  0.309017  0.809017  0.500000  -129.52125 
-0.809017 0.500000  -0.309017 339.09103  
47 'point symmetry operation' ?     ?     0.500000  -0.309017 0.809017  -0.00788   -0.309017 0.809017  0.500000  -0.00487   
-0.809017 -0.500000 0.309017  419.18324  
48 'point symmetry operation' ?     ?     0.000000  0.000000  1.000000  -0.03610   1.000000  0.000000  0.000000  0.06900    
0.000000  1.000000  0.000000  -0.03290   
49 'point symmetry operation' ?     ?     0.500000  0.309017  0.809017  -129.56690 -0.309017 -0.809017 0.500000  339.18505  
0.809017  -0.500000 -0.309017 209.64366  
50 'point symmetry operation' ?     ?     0.000000  1.000000  0.000000  -0.06900   0.000000  0.000000  1.000000  0.03290    
1.000000  0.000000  0.000000  0.03610    
51 'point symmetry operation' ?     ?     0.809017  -0.500000 -0.309017 209.60756  0.500000  0.309017  0.809017  -129.49790 
-0.309017 -0.809017 0.500000  339.15215  
52 'point symmetry operation' ?     ?     -0.809017 -0.500000 0.309017  419.14714  0.500000  -0.309017 0.809017  0.06112    
-0.309017 0.809017  0.500000  -0.03777   
53 'point symmetry operation' ?     ?     0.309017  -0.809017 0.500000  209.59967  0.809017  0.500000  0.309017  -129.49303 
-0.500000 0.309017  0.809017  80.03110   
54 'point symmetry operation' ?     ?     -0.500000 0.309017  0.809017  79.99500   0.309017  -0.809017 0.500000  209.66867  
0.809017  0.500000  0.309017  -129.52593 
55 'point symmetry operation' ?     ?     0.809017  0.500000  0.309017  -129.56203 -0.500000 0.309017  0.809017  80.06400   
0.309017  -0.809017 0.500000  209.63577  
56 'point symmetry operation' ?     ?     0.309017  0.809017  -0.500000 80.00775   -0.809017 0.500000  0.309017  209.58524  
0.500000  0.309017  0.809017  -129.53080 
57 'point symmetry operation' ?     ?     0.309017  -0.809017 -0.500000 419.19767  0.809017  0.500000  -0.309017 0.04566    
0.500000  -0.309017 0.809017  0.02822    
58 'point symmetry operation' ?     ?     -1.000000 0.000000  0.000000  419.12380  0.000000  -1.000000 0.000000  419.26180  
0.000000  0.000000  1.000000  0.00000    
59 'point symmetry operation' ?     ?     -0.309017 -0.809017 0.500000  339.11605  0.809017  -0.500000 -0.309017 209.67656  
0.500000  0.309017  0.809017  -129.53080 
60 'point symmetry operation' ?     ?     -0.309017 0.809017  0.500000  -0.07387   -0.809017 -0.500000 0.309017  419.21614  
0.500000  -0.309017 0.809017  0.02822    
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL A 56  ? VAL A 61  ? VAL A 56  VAL A 61  1 ? 6  
HELX_P HELX_P2  AA2 ARG A 72  ? SER A 75  ? ARG A 72  SER A 75  5 ? 4  
HELX_P HELX_P3  AA3 SER A 76  ? ALA A 82  ? SER A 76  ALA A 82  1 ? 7  
HELX_P HELX_P4  AA4 VAL A 116 ? GLU A 123 ? VAL A 116 GLU A 123 1 ? 8  
HELX_P HELX_P5  AA5 ASP A 172 ? THR A 177 ? ASP A 172 THR A 177 5 ? 6  
HELX_P HELX_P6  AA6 ALA A 232 ? ASP A 236 ? ALA A 232 ASP A 236 5 ? 5  
HELX_P HELX_P7  AA7 LYS A 287 ? LEU A 291 ? LYS A 287 LEU A 291 5 ? 5  
HELX_P HELX_P8  AA8 ASP B 35  ? ASN B 39  ? ASP B 35  ASN B 39  5 ? 5  
HELX_P HELX_P9  AA9 TYR B 104 ? ARG B 106 ? TYR B 104 ARG B 106 5 ? 3  
HELX_P HELX_P10 AB1 ARG B 112 ? ALA B 116 ? ARG B 112 ALA B 116 5 ? 5  
HELX_P HELX_P11 AB2 PRO B 125 ? ALA B 129 ? PRO B 125 ALA B 129 5 ? 5  
HELX_P HELX_P12 AB3 PRO B 152 ? ASP B 157 ? PRO B 152 ASP B 157 5 ? 6  
HELX_P HELX_P13 AB4 MET B 158 ? TYR B 167 ? MET B 158 TYR B 167 1 ? 10 
HELX_P HELX_P14 AB5 SER B 213 ? ASN B 218 ? SER B 213 ASN B 218 1 ? 6  
HELX_P HELX_P15 AB6 LEU B 256 ? PHE B 262 ? LEU B 256 PHE B 262 5 ? 7  
HELX_P HELX_P16 AB7 MET C 43  ? GLU C 48  ? MET C 43  GLU C 48  1 ? 6  
HELX_P HELX_P17 AB8 THR C 64  ? ARG C 69  ? THR C 64  ARG C 69  5 ? 6  
HELX_P HELX_P18 AB9 ASP C 92  ? HIS C 97  ? ASP C 92  HIS C 97  1 ? 6  
HELX_P HELX_P19 AC1 THR C 98  ? ASN C 105 ? THR C 98  ASN C 105 1 ? 8  
HELX_P HELX_P20 AC2 LYS C 144 ? MET C 149 ? LYS C 144 MET C 149 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LEU 
_struct_mon_prot_cis.label_seq_id           151 
_struct_mon_prot_cis.label_asym_id          B 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LEU 
_struct_mon_prot_cis.auth_seq_id            151 
_struct_mon_prot_cis.auth_asym_id           B 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    152 
_struct_mon_prot_cis.pdbx_label_asym_id_2   B 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     152 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    B 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -0.04 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 4 ? 
AA3 ? 2 ? 
AA4 ? 7 ? 
AA5 ? 5 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
AA8 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 6 ? anti-parallel 
AA1 2 4 ? anti-parallel 
AA1 2 5 ? anti-parallel 
AA1 2 6 ? anti-parallel 
AA1 3 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 5 ? parallel      
AA4 2 7 ? anti-parallel 
AA4 3 7 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 4 6 ? anti-parallel 
AA4 4 7 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 85  ? ASN A 94  ? ALA A 85  ASN A 94  
AA1 2 PHE A 125 ? VAL A 137 ? PHE A 125 VAL A 137 
AA1 3 ALA A 140 ? PHE A 142 ? ALA A 140 PHE A 142 
AA1 4 ALA A 192 ? VAL A 196 ? ALA A 192 VAL A 196 
AA1 5 TYR A 205 ? SER A 206 ? TYR A 205 SER A 206 
AA1 6 VAL A 253 ? PRO A 271 ? VAL A 253 PRO A 271 
AA1 7 GLU C 39  ? VAL C 40  ? GLU C 39  VAL C 40  
AA2 1 ALA A 106 ? LYS A 109 ? ALA A 106 LYS A 109 
AA2 2 ILE A 239 ? VAL A 244 ? ILE A 239 VAL A 244 
AA2 3 VAL A 154 ? VAL A 160 ? VAL A 154 VAL A 160 
AA2 4 SER A 182 ? THR A 186 ? SER A 182 THR A 186 
AA3 1 LEU B 83  ? LEU B 87  ? LEU B 83  LEU B 87  
AA3 2 SER B 90  ? ALA B 94  ? SER B 90  ALA B 94  
AA4 1 ALA B 97  ? VAL B 102 ? ALA B 97  VAL B 102 
AA4 2 TYR B 133 ? THR B 134 ? TYR B 133 THR B 134 
AA4 3 VAL B 138 ? SER B 139 ? VAL B 138 SER B 139 
AA4 4 HIS B 168 ? GLN B 180 ? HIS B 168 GLN B 180 
AA4 5 CYS B 274 ? LEU B 279 ? CYS B 274 LEU B 279 
AA4 6 ASP B 288 ? SER B 289 ? ASP B 288 SER B 289 
AA4 7 PRO B 317 ? LEU B 332 ? PRO B 317 LEU B 332 
AA5 1 GLY B 224 ? THR B 225 ? GLY B 224 THR B 225 
AA5 2 TRP B 147 ? LYS B 150 ? TRP B 147 LYS B 150 
AA5 3 GLY B 297 ? PHE B 308 ? GLY B 297 PHE B 308 
AA5 4 HIS B 187 ? ALA B 195 ? HIS B 187 ALA B 195 
AA5 5 HIS B 264 ? ASN B 268 ? HIS B 264 ASN B 268 
AA6 1 VAL C 70  ? ARG C 71  ? VAL C 70  ARG C 71  
AA6 2 ASP C 209 ? ALA C 216 ? ASP C 209 ALA C 216 
AA6 3 LEU C 114 ? PHE C 120 ? LEU C 114 PHE C 120 
AA6 4 SER C 163 ? VAL C 168 ? SER C 163 VAL C 168 
AA7 1 LEU C 83  ? SER C 86  ? LEU C 83  SER C 86  
AA7 2 TYR C 189 ? VAL C 199 ? TYR C 189 VAL C 199 
AA7 3 THR C 127 ? ALA C 135 ? THR C 127 ALA C 135 
AA7 4 THR C 152 ? ASP C 157 ? THR C 152 ASP C 157 
AA8 1 ARG C 177 ? LEU C 178 ? ARG C 177 LEU C 178 
AA8 2 TYR C 107 ? TRP C 110 ? TYR C 107 TRP C 110 
AA8 3 VAL C 222 ? LEU C 225 ? VAL C 222 LEU C 225 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 6 N MET A 90  ? N MET A 90  O ILE A 257 ? O ILE A 257 
AA1 2 4 N LEU A 134 ? N LEU A 134 O ILE A 194 ? O ILE A 194 
AA1 2 5 N SER A 128 ? N SER A 128 O TYR A 205 ? O TYR A 205 
AA1 2 6 N THR A 135 ? N THR A 135 O TYR A 260 ? O TYR A 260 
AA1 3 6 N ASN A 141 ? N ASN A 141 O THR A 254 ? O THR A 254 
AA1 6 7 N VAL A 268 ? N VAL A 268 O VAL C 40  ? O VAL C 40  
AA2 1 2 N TRP A 108 ? N TRP A 108 O LEU A 240 ? O LEU A 240 
AA2 2 3 O ALA A 241 ? O ALA A 241 N MET A 158 ? N MET A 158 
AA2 3 4 N TYR A 155 ? N TYR A 155 O TYR A 185 ? O TYR A 185 
AA3 1 2 N LEU B 85  ? N LEU B 85  O ILE B 92  ? O ILE B 92  
AA4 1 5 N VAL B 101 ? N VAL B 101 O VAL B 278 ? O VAL B 278 
AA4 2 7 N TYR B 133 ? N TYR B 133 O ILE B 322 ? O ILE B 322 
AA4 3 7 N VAL B 138 ? N VAL B 138 O ILE B 318 ? O ILE B 318 
AA4 4 5 N VAL B 179 ? N VAL B 179 O ALA B 275 ? O ALA B 275 
AA4 4 6 N GLY B 171 ? N GLY B 171 O ASP B 288 ? O ASP B 288 
AA4 4 7 N GLN B 180 ? N GLN B 180 O THR B 319 ? O THR B 319 
AA5 1 2 O GLY B 224 ? O GLY B 224 N TRP B 148 ? N TRP B 148 
AA5 2 3 N TRP B 149 ? N TRP B 149 O ILE B 298 ? O ILE B 298 
AA5 3 4 O ALA B 299 ? O ALA B 299 N PHE B 194 ? N PHE B 194 
AA5 4 5 N VAL B 193 ? N VAL B 193 O GLN B 265 ? O GLN B 265 
AA6 1 2 N VAL C 70  ? N VAL C 70  O ILE C 210 ? O ILE C 210 
AA6 2 3 O LEU C 211 ? O LEU C 211 N MET C 119 ? N MET C 119 
AA6 3 4 N PHE C 116 ? N PHE C 116 O MET C 166 ? O MET C 166 
AA7 1 2 N LEU C 83  ? N LEU C 83  O VAL C 192 ? O VAL C 192 
AA7 2 3 O VAL C 199 ? O VAL C 199 N THR C 127 ? N THR C 127 
AA7 3 4 N VAL C 132 ? N VAL C 132 O VAL C 154 ? O VAL C 154 
AA8 1 2 O ARG C 177 ? O ARG C 177 N TRP C 110 ? N TRP C 110 
AA8 2 3 N THR C 108 ? N THR C 108 O LEU C 224 ? O LEU C 224 
# 
_pdbx_entry_details.entry_id                   9EYY 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OG B SER 213 ? ? OD1 B ASN 216 ? ? 2.04 
2 1 OG A SER 195 ? ? OG  C SER 21  ? ? 2.10 
3 1 OH A TYR 280 ? ? O   B ASN 206 ? ? 2.11 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ALA A 204 ? ? -171.91 142.69  
2  1 CYS A 270 ? ? 60.29   72.99   
3  1 LEU A 291 ? ? -90.62  52.80   
4  1 ALA B 94  ? ? -160.10 116.33  
5  1 ASN B 99  ? ? 68.05   -175.49 
6  1 GLU B 126 ? ? 63.68   -115.57 
7  1 CYS B 130 ? ? -90.28  58.01   
8  1 GLU B 143 ? ? -97.71  58.77   
9  1 SER B 173 ? ? -171.17 141.16  
10 1 THR B 254 ? ? -79.03  -167.60 
11 1 ASN B 283 ? ? -172.83 149.87  
12 1 PHE B 308 ? ? -160.45 116.02  
13 1 ARG B 333 ? ? -172.68 -173.90 
14 1 ASN B 334 ? ? -44.42  151.94  
15 1 PRO C 54  ? ? -69.58  81.12   
16 1 ALA C 59  ? ? 52.26   -113.97 
17 1 SER C 88  ? ? -111.04 79.28   
18 1 THR C 185 ? ? -96.82  57.91   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9EYY 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   'Cross-correlation coefficient' 
_em_3d_fitting.details           
;Initial model was rigid body fitted using UCSF chimera and Coot.  Global minimization and B-factor refinement 
was performed in real space using phenix_real.space.refine.
;
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'RIGID BODY FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  1HXS 
_em_3d_fitting_list.pdb_chain_id                  ? 
_em_3d_fitting_list.pdb_chain_residue_range       ? 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                1HXS 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    9EYY 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'BACK PROJECTION' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     
'Final reconstruction was sharpened with Post-processing in RELION using an inverse B-factor of -61.8 Angstroms.' 
_em_3d_reconstruction.resolution                  3.3 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               1320 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          1 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       '1 x DPBS, 20 mM EDTA, pH 7.0' 
_em_buffer.pH            7.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 VIRUS 
_em_entity_assembly.name                 'Human poliovirus 1 Mahoney' 
_em_entity_assembly.details              'Recombinantly expressed virus-like particle of poliovirus type 1 (Mahoney strain).' 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3' 
# 
_em_image_scans.entry_id                9EYY 
_em_image_scans.id                      1 
_em_image_scans.number_digital_images   ? 
_em_image_scans.details                 ? 
_em_image_scans.scanner_model           ? 
_em_image_scans.sampling_size           5.0 
_em_image_scans.od_range                ? 
_em_image_scans.quant_bit_size          ? 
_em_image_scans.citation_id             ? 
_em_image_scans.dimension_height        ? 
_em_image_scans.dimension_width         ? 
_em_image_scans.frames_per_image        30 
_em_image_scans.image_recording_id      1 
_em_image_scans.used_frames_per_image   1-30 
# 
_em_imaging.entry_id                        9EYY 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'DARK FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2900 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           130000 
_em_imaging.calibrated_magnification        47619 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            100 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        C-flat-2/1 
_em_sample_support.details          
'The specific type of grid used was C-flatTM holey carbon copper grids (product No. CF312, Electron Microscopy Sciences).' 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_virus_entity.id                    1 
_em_virus_entity.virus_host_category   ? 
_em_virus_entity.virus_type            'VIRUS-LIKE PARTICLE' 
_em_virus_entity.virus_isolate         SEROTYPE 
_em_virus_entity.entity_assembly_id    1 
_em_virus_entity.enveloped             NO 
_em_virus_entity.empty                 YES 
_em_virus_entity.details               ? 
# 
_em_vitrification.entry_id              9EYY 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE-PROPANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               
'3-4 ul of sample double blotted for 3.5 seconds with -15 blot force on FEI Vitrobot mark IV.' 
# 
_em_experiment.entry_id                9EYY 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9EYY 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        I 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 1   ? A GLY 1   
2  1 Y 1 A LEU 2   ? A LEU 2   
3  1 Y 1 A GLY 3   ? A GLY 3   
4  1 Y 1 A GLN 4   ? A GLN 4   
5  1 Y 1 A MET 5   ? A MET 5   
6  1 Y 1 A LEU 6   ? A LEU 6   
7  1 Y 1 A GLU 7   ? A GLU 7   
8  1 Y 1 A SER 8   ? A SER 8   
9  1 Y 1 A MET 9   ? A MET 9   
10 1 Y 1 A ILE 10  ? A ILE 10  
11 1 Y 1 A ASP 11  ? A ASP 11  
12 1 Y 1 A ASN 12  ? A ASN 12  
13 1 Y 1 A THR 13  ? A THR 13  
14 1 Y 1 A VAL 14  ? A VAL 14  
15 1 Y 1 A ARG 15  ? A ARG 15  
16 1 Y 1 A GLU 16  ? A GLU 16  
17 1 Y 1 A THR 17  ? A THR 17  
18 1 Y 1 A VAL 18  ? A VAL 18  
19 1 Y 1 A GLY 19  ? A GLY 19  
20 1 Y 1 A ALA 20  ? A ALA 20  
21 1 Y 1 A ALA 21  ? A ALA 21  
22 1 Y 1 A THR 22  ? A THR 22  
23 1 Y 1 A SER 23  ? A SER 23  
24 1 Y 1 A ARG 24  ? A ARG 24  
25 1 Y 1 B MET 1   ? B MET 1   
26 1 Y 1 B GLY 2   ? B GLY 2   
27 1 Y 1 B ALA 3   ? B ALA 3   
28 1 Y 1 B LYS 9   ? B LYS 9   
29 1 Y 1 B VAL 10  ? B VAL 10  
30 1 Y 1 B GLY 11  ? B GLY 11  
31 1 Y 1 B ALA 12  ? B ALA 12  
32 1 Y 1 B HIS 13  ? B HIS 13  
33 1 Y 1 B GLU 14  ? B GLU 14  
34 1 Y 1 B ASN 15  ? B ASN 15  
35 1 Y 1 B SER 16  ? B SER 16  
36 1 Y 1 B ASN 17  ? B ASN 17  
37 1 Y 1 B GLY 18  ? B GLY 18  
38 1 Y 1 B ALA 19  ? B ALA 19  
39 1 Y 1 B TYR 20  ? B TYR 20  
40 1 Y 1 B GLY 21  ? B GLY 21  
41 1 Y 1 B GLY 22  ? B GLY 22  
42 1 Y 1 B SER 23  ? B SER 23  
43 1 Y 1 B THR 24  ? B THR 24  
44 1 Y 1 B ILE 25  ? B ILE 25  
45 1 Y 1 B ASN 26  ? B ASN 26  
46 1 Y 1 B TYR 27  ? B TYR 27  
47 1 Y 1 B SER 42  ? B SER 42  
48 1 Y 1 B LYS 43  ? B LYS 43  
49 1 Y 1 B GLN 44  ? B GLN 44  
50 1 Y 1 B ASP 45  ? B ASP 45  
51 1 Y 1 B PHE 46  ? B PHE 46  
52 1 Y 1 B SER 47  ? B SER 47  
53 1 Y 1 B GLN 48  ? B GLN 48  
54 1 Y 1 B ASP 49  ? B ASP 49  
55 1 Y 1 B PRO 50  ? B PRO 50  
56 1 Y 1 B SER 51  ? B SER 51  
57 1 Y 1 B LYS 52  ? B LYS 52  
58 1 Y 1 B PHE 53  ? B PHE 53  
59 1 Y 1 B THR 54  ? B THR 54  
60 1 Y 1 B GLU 55  ? B GLU 55  
61 1 Y 1 B PRO 56  ? B PRO 56  
62 1 Y 1 B ILE 57  ? B ILE 57  
63 1 Y 1 B LYS 58  ? B LYS 58  
64 1 Y 1 B ASP 59  ? B ASP 59  
65 1 Y 1 B VAL 60  ? B VAL 60  
66 1 Y 1 B LEU 61  ? B LEU 61  
67 1 Y 1 B ILE 62  ? B ILE 62  
68 1 Y 1 B LYS 63  ? B LYS 63  
69 1 Y 1 B THR 64  ? B THR 64  
70 1 Y 1 B ALA 65  ? B ALA 65  
71 1 Y 1 B PRO 66  ? B PRO 66  
72 1 Y 1 B MET 67  ? B MET 67  
73 1 Y 1 B LEU 68  ? B LEU 68  
74 1 Y 1 B ASN 69  ? B ASN 69  
75 1 Y 1 B SER 70  ? B SER 70  
76 1 Y 1 B PRO 71  ? B PRO 71  
77 1 Y 1 B ASN 72  ? B ASN 72  
78 1 Y 1 B ILE 73  ? B ILE 73  
79 1 Y 1 B GLU 74  ? B GLU 74  
80 1 Y 1 B ALA 75  ? B ALA 75  
81 1 Y 1 B CYS 76  ? B CYS 76  
82 1 Y 1 B GLY 77  ? B GLY 77  
83 1 Y 1 B TYR 78  ? B TYR 78  
84 1 Y 1 B SER 79  ? B SER 79  
85 1 Y 1 C LEU 236 ? C LEU 236 
86 1 Y 1 C ALA 237 ? C ALA 237 
87 1 Y 1 C GLN 238 ? C GLN 238 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PLM C1   C N N 270 
PLM O1   O N N 271 
PLM O2   O N N 272 
PLM C2   C N N 273 
PLM C3   C N N 274 
PLM C4   C N N 275 
PLM C5   C N N 276 
PLM C6   C N N 277 
PLM C7   C N N 278 
PLM C8   C N N 279 
PLM C9   C N N 280 
PLM CA   C N N 281 
PLM CB   C N N 282 
PLM CC   C N N 283 
PLM CD   C N N 284 
PLM CE   C N N 285 
PLM CF   C N N 286 
PLM CG   C N N 287 
PLM H    H N N 288 
PLM H21  H N N 289 
PLM H22  H N N 290 
PLM H31  H N N 291 
PLM H32  H N N 292 
PLM H41  H N N 293 
PLM H42  H N N 294 
PLM H51  H N N 295 
PLM H52  H N N 296 
PLM H61  H N N 297 
PLM H62  H N N 298 
PLM H71  H N N 299 
PLM H72  H N N 300 
PLM H81  H N N 301 
PLM H82  H N N 302 
PLM H91  H N N 303 
PLM H92  H N N 304 
PLM HA1  H N N 305 
PLM HA2  H N N 306 
PLM HB1  H N N 307 
PLM HB2  H N N 308 
PLM HC1  H N N 309 
PLM HC2  H N N 310 
PLM HD1  H N N 311 
PLM HD2  H N N 312 
PLM HE1  H N N 313 
PLM HE2  H N N 314 
PLM HF1  H N N 315 
PLM HF2  H N N 316 
PLM HG1  H N N 317 
PLM HG2  H N N 318 
PLM HG3  H N N 319 
PRO N    N N N 320 
PRO CA   C N S 321 
PRO C    C N N 322 
PRO O    O N N 323 
PRO CB   C N N 324 
PRO CG   C N N 325 
PRO CD   C N N 326 
PRO OXT  O N N 327 
PRO H    H N N 328 
PRO HA   H N N 329 
PRO HB2  H N N 330 
PRO HB3  H N N 331 
PRO HG2  H N N 332 
PRO HG3  H N N 333 
PRO HD2  H N N 334 
PRO HD3  H N N 335 
PRO HXT  H N N 336 
SER N    N N N 337 
SER CA   C N S 338 
SER C    C N N 339 
SER O    O N N 340 
SER CB   C N N 341 
SER OG   O N N 342 
SER OXT  O N N 343 
SER H    H N N 344 
SER H2   H N N 345 
SER HA   H N N 346 
SER HB2  H N N 347 
SER HB3  H N N 348 
SER HG   H N N 349 
SER HXT  H N N 350 
THR N    N N N 351 
THR CA   C N S 352 
THR C    C N N 353 
THR O    O N N 354 
THR CB   C N R 355 
THR OG1  O N N 356 
THR CG2  C N N 357 
THR OXT  O N N 358 
THR H    H N N 359 
THR H2   H N N 360 
THR HA   H N N 361 
THR HB   H N N 362 
THR HG1  H N N 363 
THR HG21 H N N 364 
THR HG22 H N N 365 
THR HG23 H N N 366 
THR HXT  H N N 367 
TRP N    N N N 368 
TRP CA   C N S 369 
TRP C    C N N 370 
TRP O    O N N 371 
TRP CB   C N N 372 
TRP CG   C Y N 373 
TRP CD1  C Y N 374 
TRP CD2  C Y N 375 
TRP NE1  N Y N 376 
TRP CE2  C Y N 377 
TRP CE3  C Y N 378 
TRP CZ2  C Y N 379 
TRP CZ3  C Y N 380 
TRP CH2  C Y N 381 
TRP OXT  O N N 382 
TRP H    H N N 383 
TRP H2   H N N 384 
TRP HA   H N N 385 
TRP HB2  H N N 386 
TRP HB3  H N N 387 
TRP HD1  H N N 388 
TRP HE1  H N N 389 
TRP HE3  H N N 390 
TRP HZ2  H N N 391 
TRP HZ3  H N N 392 
TRP HH2  H N N 393 
TRP HXT  H N N 394 
TYR N    N N N 395 
TYR CA   C N S 396 
TYR C    C N N 397 
TYR O    O N N 398 
TYR CB   C N N 399 
TYR CG   C Y N 400 
TYR CD1  C Y N 401 
TYR CD2  C Y N 402 
TYR CE1  C Y N 403 
TYR CE2  C Y N 404 
TYR CZ   C Y N 405 
TYR OH   O N N 406 
TYR OXT  O N N 407 
TYR H    H N N 408 
TYR H2   H N N 409 
TYR HA   H N N 410 
TYR HB2  H N N 411 
TYR HB3  H N N 412 
TYR HD1  H N N 413 
TYR HD2  H N N 414 
TYR HE1  H N N 415 
TYR HE2  H N N 416 
TYR HH   H N N 417 
TYR HXT  H N N 418 
VAL N    N N N 419 
VAL CA   C N S 420 
VAL C    C N N 421 
VAL O    O N N 422 
VAL CB   C N N 423 
VAL CG1  C N N 424 
VAL CG2  C N N 425 
VAL OXT  O N N 426 
VAL H    H N N 427 
VAL H2   H N N 428 
VAL HA   H N N 429 
VAL HB   H N N 430 
VAL HG11 H N N 431 
VAL HG12 H N N 432 
VAL HG13 H N N 433 
VAL HG21 H N N 434 
VAL HG22 H N N 435 
VAL HG23 H N N 436 
VAL HXT  H N N 437 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PLM C1  O1   sing N N 258 
PLM C1  O2   doub N N 259 
PLM C1  C2   sing N N 260 
PLM O1  H    sing N N 261 
PLM C2  C3   sing N N 262 
PLM C2  H21  sing N N 263 
PLM C2  H22  sing N N 264 
PLM C3  C4   sing N N 265 
PLM C3  H31  sing N N 266 
PLM C3  H32  sing N N 267 
PLM C4  C5   sing N N 268 
PLM C4  H41  sing N N 269 
PLM C4  H42  sing N N 270 
PLM C5  C6   sing N N 271 
PLM C5  H51  sing N N 272 
PLM C5  H52  sing N N 273 
PLM C6  C7   sing N N 274 
PLM C6  H61  sing N N 275 
PLM C6  H62  sing N N 276 
PLM C7  C8   sing N N 277 
PLM C7  H71  sing N N 278 
PLM C7  H72  sing N N 279 
PLM C8  C9   sing N N 280 
PLM C8  H81  sing N N 281 
PLM C8  H82  sing N N 282 
PLM C9  CA   sing N N 283 
PLM C9  H91  sing N N 284 
PLM C9  H92  sing N N 285 
PLM CA  CB   sing N N 286 
PLM CA  HA1  sing N N 287 
PLM CA  HA2  sing N N 288 
PLM CB  CC   sing N N 289 
PLM CB  HB1  sing N N 290 
PLM CB  HB2  sing N N 291 
PLM CC  CD   sing N N 292 
PLM CC  HC1  sing N N 293 
PLM CC  HC2  sing N N 294 
PLM CD  CE   sing N N 295 
PLM CD  HD1  sing N N 296 
PLM CD  HD2  sing N N 297 
PLM CE  CF   sing N N 298 
PLM CE  HE1  sing N N 299 
PLM CE  HE2  sing N N 300 
PLM CF  CG   sing N N 301 
PLM CF  HF1  sing N N 302 
PLM CF  HF2  sing N N 303 
PLM CG  HG1  sing N N 304 
PLM CG  HG2  sing N N 305 
PLM CG  HG3  sing N N 306 
PRO N   CA   sing N N 307 
PRO N   CD   sing N N 308 
PRO N   H    sing N N 309 
PRO CA  C    sing N N 310 
PRO CA  CB   sing N N 311 
PRO CA  HA   sing N N 312 
PRO C   O    doub N N 313 
PRO C   OXT  sing N N 314 
PRO CB  CG   sing N N 315 
PRO CB  HB2  sing N N 316 
PRO CB  HB3  sing N N 317 
PRO CG  CD   sing N N 318 
PRO CG  HG2  sing N N 319 
PRO CG  HG3  sing N N 320 
PRO CD  HD2  sing N N 321 
PRO CD  HD3  sing N N 322 
PRO OXT HXT  sing N N 323 
SER N   CA   sing N N 324 
SER N   H    sing N N 325 
SER N   H2   sing N N 326 
SER CA  C    sing N N 327 
SER CA  CB   sing N N 328 
SER CA  HA   sing N N 329 
SER C   O    doub N N 330 
SER C   OXT  sing N N 331 
SER CB  OG   sing N N 332 
SER CB  HB2  sing N N 333 
SER CB  HB3  sing N N 334 
SER OG  HG   sing N N 335 
SER OXT HXT  sing N N 336 
THR N   CA   sing N N 337 
THR N   H    sing N N 338 
THR N   H2   sing N N 339 
THR CA  C    sing N N 340 
THR CA  CB   sing N N 341 
THR CA  HA   sing N N 342 
THR C   O    doub N N 343 
THR C   OXT  sing N N 344 
THR CB  OG1  sing N N 345 
THR CB  CG2  sing N N 346 
THR CB  HB   sing N N 347 
THR OG1 HG1  sing N N 348 
THR CG2 HG21 sing N N 349 
THR CG2 HG22 sing N N 350 
THR CG2 HG23 sing N N 351 
THR OXT HXT  sing N N 352 
TRP N   CA   sing N N 353 
TRP N   H    sing N N 354 
TRP N   H2   sing N N 355 
TRP CA  C    sing N N 356 
TRP CA  CB   sing N N 357 
TRP CA  HA   sing N N 358 
TRP C   O    doub N N 359 
TRP C   OXT  sing N N 360 
TRP CB  CG   sing N N 361 
TRP CB  HB2  sing N N 362 
TRP CB  HB3  sing N N 363 
TRP CG  CD1  doub Y N 364 
TRP CG  CD2  sing Y N 365 
TRP CD1 NE1  sing Y N 366 
TRP CD1 HD1  sing N N 367 
TRP CD2 CE2  doub Y N 368 
TRP CD2 CE3  sing Y N 369 
TRP NE1 CE2  sing Y N 370 
TRP NE1 HE1  sing N N 371 
TRP CE2 CZ2  sing Y N 372 
TRP CE3 CZ3  doub Y N 373 
TRP CE3 HE3  sing N N 374 
TRP CZ2 CH2  doub Y N 375 
TRP CZ2 HZ2  sing N N 376 
TRP CZ3 CH2  sing Y N 377 
TRP CZ3 HZ3  sing N N 378 
TRP CH2 HH2  sing N N 379 
TRP OXT HXT  sing N N 380 
TYR N   CA   sing N N 381 
TYR N   H    sing N N 382 
TYR N   H2   sing N N 383 
TYR CA  C    sing N N 384 
TYR CA  CB   sing N N 385 
TYR CA  HA   sing N N 386 
TYR C   O    doub N N 387 
TYR C   OXT  sing N N 388 
TYR CB  CG   sing N N 389 
TYR CB  HB2  sing N N 390 
TYR CB  HB3  sing N N 391 
TYR CG  CD1  doub Y N 392 
TYR CG  CD2  sing Y N 393 
TYR CD1 CE1  sing Y N 394 
TYR CD1 HD1  sing N N 395 
TYR CD2 CE2  doub Y N 396 
TYR CD2 HD2  sing N N 397 
TYR CE1 CZ   doub Y N 398 
TYR CE1 HE1  sing N N 399 
TYR CE2 CZ   sing Y N 400 
TYR CE2 HE2  sing N N 401 
TYR CZ  OH   sing N N 402 
TYR OH  HH   sing N N 403 
TYR OXT HXT  sing N N 404 
VAL N   CA   sing N N 405 
VAL N   H    sing N N 406 
VAL N   H2   sing N N 407 
VAL CA  C    sing N N 408 
VAL CA  CB   sing N N 409 
VAL CA  HA   sing N N 410 
VAL C   O    doub N N 411 
VAL C   OXT  sing N N 412 
VAL CB  CG1  sing N N 413 
VAL CB  CG2  sing N N 414 
VAL CB  HB   sing N N 415 
VAL CG1 HG11 sing N N 416 
VAL CG1 HG12 sing N N 417 
VAL CG1 HG13 sing N N 418 
VAL CG2 HG21 sing N N 419 
VAL CG2 HG22 sing N N 420 
VAL CG2 HG23 sing N N 421 
VAL OXT HXT  sing N N 422 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-09 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           9EYY 
_em_admin.last_update        2025-01-29 
_em_admin.map_release_date   2025-01-29 
_em_admin.title              
'Poliovirus type 1 (strain Mahoney) native conformation stabilised virus-like particle (PV1 SC6b) from a yeast expression system.' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 1  x  ? 1 DPBS 
1 20 mM ? 2 EDTA 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                5.84 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          12081 
_em_entity_assembly_naturalsource.organism             'Human poliovirus 1 Mahoney' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               Mahoney 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          4922 
_em_entity_assembly_recombinant.organism             'Komagataella pastoris' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               6.0 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         41.14 
_em_image_recording.details                             'Pixel sampling was 1.05 A/pixel. Energy filter was Gatan GIF Quantum.' 
_em_image_recording.detector_mode                       COUNTING 
_em_image_recording.film_or_detector_model              'GATAN K2 SUMMIT (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     4282 
# 
_em_particle_selection.details                  
'Particle picking was performed using Xmipp as part of the Scipion software framework.' 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   4578 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'MODEL REFINEMENT'              ? 1  ? ? ? PHENIX 1.20.1_4487: 
'IMAGE ACQUISITION'             ? 2  1 1 1 ?      ?            
'PARTICLE SELECTION'            ? 3  1 1 1 ?      ?            
'VOLUME SELECTION'              ? 4  1 1 1 ?      ?            
CLASSIFICATION                  ? 5  1 1 1 ?      ?            
MASKING                         ? 6  1 1 1 ?      ?            
RECONSTRUCTION                  ? 7  1 1 1 ?      ?            
'INITIAL EULER ASSIGNMENT'      ? 8  1 1 1 ?      ?            
'FINAL EULER ASSIGNMENT'        ? 9  1 1 1 ?      ?            
'CTF CORRECTION'                ? 10 1 1 1 ?      ?            
'LAYERLINE INDEXING'            ? 11 1 1 1 ?      ?            
'DIFFRACTION INDEXING'          ? 12 1 1 1 ?      ?            
'MODEL FITTING'                 ? 13 1 1 1 ?      ?            
'SERIES ALIGNMENT'              ? 14 1 1 1 ?      ?            
'MOLECULAR REPLACEMENT'         ? 15 1 1 1 ?      ?            
'LATTICE DISTORTION CORRECTION' ? 16 1 1 1 ?      ?            
'SYMMETRY DETERMINATION'        ? 17 1 1 1 ?      ?            
'CRYSTALLOGRAPHY MERGING'       ? 18 1 1 1 ?      ?            
OTHER                           ? 19 1 1 1 ?      ?            
# 
_em_specimen.concentration           1.1 
_em_specimen.details                 'Sample purified by sucrose density gradient ultracentrifugation.' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_em_virus_natural_host.entity_assembly_id   1 
_em_virus_natural_host.id                   1 
_em_virus_natural_host.ncbi_tax_id          9606 
_em_virus_natural_host.organism             'Homo sapiens' 
_em_virus_natural_host.strain               ? 
# 
_em_virus_shell.diameter             310 
_em_virus_shell.entity_assembly_id   1 
_em_virus_shell.id                   1 
_em_virus_shell.name                 'Virus shell 1' 
_em_virus_shell.triangulation        1 
# 
_pdbx_audit_support.funding_organization   'Bill & Melinda Gates Foundation' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           RG.IMCB.I8-TSA-083 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1HXS 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9EYY 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP A 1 25  ? 185.866 248.439 310.618 1.00 96.79  ? 25  ASP A N   1 
ATOM   2    C CA  . ASP A 1 25  ? 185.206 247.323 309.951 1.00 100.84 ? 25  ASP A CA  1 
ATOM   3    C C   . ASP A 1 25  ? 183.692 247.451 310.059 1.00 98.74  ? 25  ASP A C   1 
ATOM   4    O O   . ASP A 1 25  ? 183.167 247.838 311.101 1.00 98.99  ? 25  ASP A O   1 
ATOM   5    C CB  . ASP A 1 25  ? 185.661 245.990 310.550 1.00 102.06 ? 25  ASP A CB  1 
ATOM   6    C CG  . ASP A 1 25  ? 185.147 245.777 311.962 1.00 98.90  ? 25  ASP A CG  1 
ATOM   7    O OD1 . ASP A 1 25  ? 185.006 246.771 312.703 1.00 97.87  ? 25  ASP A OD1 1 
ATOM   8    O OD2 . ASP A 1 25  ? 184.882 244.614 312.331 1.00 95.93  ? 25  ASP A OD2 1 
ATOM   9    N N   . ALA A 1 26  ? 182.993 247.121 308.978 1.00 101.31 ? 26  ALA A N   1 
ATOM   10   C CA  . ALA A 1 26  ? 181.535 247.167 308.965 1.00 101.85 ? 26  ALA A CA  1 
ATOM   11   C C   . ALA A 1 26  ? 181.003 245.924 309.665 1.00 100.11 ? 26  ALA A C   1 
ATOM   12   O O   . ALA A 1 26  ? 181.180 244.804 309.176 1.00 100.32 ? 26  ALA A O   1 
ATOM   13   C CB  . ALA A 1 26  ? 181.016 247.257 307.533 1.00 101.46 ? 26  ALA A CB  1 
ATOM   14   N N   . LEU A 1 27  ? 180.353 246.118 310.812 1.00 89.95  ? 27  LEU A N   1 
ATOM   15   C CA  . LEU A 1 27  ? 179.797 244.999 311.549 1.00 88.04  ? 27  LEU A CA  1 
ATOM   16   C C   . LEU A 1 27  ? 178.832 244.215 310.662 1.00 91.88  ? 27  LEU A C   1 
ATOM   17   O O   . LEU A 1 27  ? 178.391 244.706 309.620 1.00 91.70  ? 27  LEU A O   1 
ATOM   18   C CB  . LEU A 1 27  ? 179.084 245.493 312.805 1.00 88.31  ? 27  LEU A CB  1 
ATOM   19   C CG  . LEU A 1 27  ? 179.992 245.890 313.970 1.00 88.03  ? 27  LEU A CG  1 
ATOM   20   C CD1 . LEU A 1 27  ? 179.174 246.497 315.093 1.00 87.76  ? 27  LEU A CD1 1 
ATOM   21   C CD2 . LEU A 1 27  ? 180.782 244.692 314.474 1.00 85.29  ? 27  LEU A CD2 1 
ATOM   22   N N   . PRO A 1 28  ? 178.497 242.985 311.051 1.00 92.93  ? 28  PRO A N   1 
ATOM   23   C CA  . PRO A 1 28  ? 177.622 242.165 310.206 1.00 92.03  ? 28  PRO A CA  1 
ATOM   24   C C   . PRO A 1 28  ? 176.290 242.851 309.943 1.00 90.50  ? 28  PRO A C   1 
ATOM   25   O O   . PRO A 1 28  ? 175.698 243.466 310.833 1.00 89.44  ? 28  PRO A O   1 
ATOM   26   C CB  . PRO A 1 28  ? 177.441 240.882 311.024 1.00 91.78  ? 28  PRO A CB  1 
ATOM   27   C CG  . PRO A 1 28  ? 178.622 240.834 311.924 1.00 90.94  ? 28  PRO A CG  1 
ATOM   28   C CD  . PRO A 1 28  ? 178.949 242.256 312.248 1.00 88.08  ? 28  PRO A CD  1 
ATOM   29   N N   . ASN A 1 29  ? 175.821 242.739 308.704 1.00 95.81  ? 29  ASN A N   1 
ATOM   30   C CA  . ASN A 1 29  ? 174.518 243.282 308.350 1.00 96.67  ? 29  ASN A CA  1 
ATOM   31   C C   . ASN A 1 29  ? 173.412 242.477 309.015 1.00 97.53  ? 29  ASN A C   1 
ATOM   32   O O   . ASN A 1 29  ? 173.470 241.246 309.084 1.00 99.30  ? 29  ASN A O   1 
ATOM   33   C CB  . ASN A 1 29  ? 174.328 243.279 306.834 1.00 97.48  ? 29  ASN A CB  1 
ATOM   34   C CG  . ASN A 1 29  ? 175.022 244.442 306.158 1.00 99.21  ? 29  ASN A CG  1 
ATOM   35   O OD1 . ASN A 1 29  ? 175.171 245.515 306.741 1.00 101.11 ? 29  ASN A OD1 1 
ATOM   36   N ND2 . ASN A 1 29  ? 175.448 244.237 304.917 1.00 99.76  ? 29  ASN A ND2 1 
ATOM   37   N N   . THR A 1 30  ? 172.398 243.182 309.506 1.00 98.95  ? 30  THR A N   1 
ATOM   38   C CA  . THR A 1 30  ? 171.259 242.550 310.167 1.00 102.04 ? 30  THR A CA  1 
ATOM   39   C C   . THR A 1 30  ? 170.305 242.057 309.087 1.00 101.66 ? 30  THR A C   1 
ATOM   40   O O   . THR A 1 30  ? 169.440 242.786 308.602 1.00 99.27  ? 30  THR A O   1 
ATOM   41   C CB  . THR A 1 30  ? 170.583 243.527 311.120 1.00 103.48 ? 30  THR A CB  1 
ATOM   42   O OG1 . THR A 1 30  ? 171.449 243.790 312.233 1.00 103.54 ? 30  THR A OG1 1 
ATOM   43   C CG2 . THR A 1 30  ? 169.271 242.964 311.624 1.00 98.35  ? 30  THR A CG2 1 
ATOM   44   N N   . GLU A 1 31  ? 170.471 240.792 308.711 1.00 105.84 ? 31  GLU A N   1 
ATOM   45   C CA  . GLU A 1 31  ? 169.714 240.218 307.610 1.00 104.06 ? 31  GLU A CA  1 
ATOM   46   C C   . GLU A 1 31  ? 168.228 240.152 307.950 1.00 104.90 ? 31  GLU A C   1 
ATOM   47   O O   . GLU A 1 31  ? 167.824 240.185 309.115 1.00 104.11 ? 31  GLU A O   1 
ATOM   48   C CB  . GLU A 1 31  ? 170.237 238.821 307.282 1.00 103.80 ? 31  GLU A CB  1 
ATOM   49   C CG  . GLU A 1 31  ? 170.065 237.824 308.417 1.00 105.67 ? 31  GLU A CG  1 
ATOM   50   C CD  . GLU A 1 31  ? 170.940 236.599 308.258 1.00 105.47 ? 31  GLU A CD  1 
ATOM   51   O OE1 . GLU A 1 31  ? 171.693 236.526 307.265 1.00 107.03 ? 31  GLU A OE1 1 
ATOM   52   O OE2 . GLU A 1 31  ? 170.877 235.709 309.131 1.00 102.37 ? 31  GLU A OE2 1 
ATOM   53   N N   . ALA A 1 32  ? 167.411 240.059 306.905 1.00 103.36 ? 32  ALA A N   1 
ATOM   54   C CA  . ALA A 1 32  ? 165.968 240.008 307.066 1.00 100.28 ? 32  ALA A CA  1 
ATOM   55   C C   . ALA A 1 32  ? 165.524 238.628 307.539 1.00 102.81 ? 32  ALA A C   1 
ATOM   56   O O   . ALA A 1 32  ? 166.259 237.641 307.447 1.00 104.54 ? 32  ALA A O   1 
ATOM   57   C CB  . ALA A 1 32  ? 165.269 240.357 305.754 1.00 99.29  ? 32  ALA A CB  1 
ATOM   58   N N   . SER A 1 33  ? 164.298 238.571 308.052 1.00 102.41 ? 33  SER A N   1 
ATOM   59   C CA  . SER A 1 33  ? 163.723 237.323 308.532 1.00 103.58 ? 33  SER A CA  1 
ATOM   60   C C   . SER A 1 33  ? 162.207 237.443 308.495 1.00 101.06 ? 33  SER A C   1 
ATOM   61   O O   . SER A 1 33  ? 161.655 238.542 308.400 1.00 98.00  ? 33  SER A O   1 
ATOM   62   C CB  . SER A 1 33  ? 164.207 236.988 309.947 1.00 100.35 ? 33  SER A CB  1 
ATOM   63   O OG  . SER A 1 33  ? 163.637 235.776 310.408 1.00 97.95  ? 33  SER A OG  1 
ATOM   64   N N   . GLY A 1 34  ? 161.542 236.294 308.571 1.00 101.59 ? 34  GLY A N   1 
ATOM   65   C CA  . GLY A 1 34  ? 160.100 236.245 308.538 1.00 101.80 ? 34  GLY A CA  1 
ATOM   66   C C   . GLY A 1 34  ? 159.547 235.145 309.421 1.00 103.03 ? 34  GLY A C   1 
ATOM   67   O O   . GLY A 1 34  ? 160.280 234.490 310.168 1.00 104.18 ? 34  GLY A O   1 
ATOM   68   N N   . PRO A 1 35  ? 158.236 234.924 309.356 1.00 95.40  ? 35  PRO A N   1 
ATOM   69   C CA  . PRO A 1 35  ? 157.633 233.860 310.167 1.00 95.72  ? 35  PRO A CA  1 
ATOM   70   C C   . PRO A 1 35  ? 158.248 232.506 309.845 1.00 94.88  ? 35  PRO A C   1 
ATOM   71   O O   . PRO A 1 35  ? 158.548 232.198 308.690 1.00 95.12  ? 35  PRO A O   1 
ATOM   72   C CB  . PRO A 1 35  ? 156.151 233.913 309.778 1.00 94.36  ? 35  PRO A CB  1 
ATOM   73   C CG  . PRO A 1 35  ? 155.942 235.284 309.235 1.00 92.50  ? 35  PRO A CG  1 
ATOM   74   C CD  . PRO A 1 35  ? 157.230 235.668 308.581 1.00 91.59  ? 35  PRO A CD  1 
ATOM   75   N N   . THR A 1 36  ? 158.436 231.696 310.885 1.00 96.21  ? 36  THR A N   1 
ATOM   76   C CA  . THR A 1 36  ? 158.993 230.361 310.732 1.00 98.27  ? 36  THR A CA  1 
ATOM   77   C C   . THR A 1 36  ? 158.231 229.394 311.625 1.00 96.69  ? 36  THR A C   1 
ATOM   78   O O   . THR A 1 36  ? 157.623 229.784 312.625 1.00 97.18  ? 36  THR A O   1 
ATOM   79   C CB  . THR A 1 36  ? 160.490 230.323 311.069 1.00 97.21  ? 36  THR A CB  1 
ATOM   80   O OG1 . THR A 1 36  ? 161.004 229.010 310.815 1.00 95.11  ? 36  THR A OG1 1 
ATOM   81   C CG2 . THR A 1 36  ? 160.725 230.682 312.529 1.00 97.06  ? 36  THR A CG2 1 
ATOM   82   N N   . HIS A 1 37  ? 158.273 228.113 311.245 1.00 91.95  ? 37  HIS A N   1 
ATOM   83   C CA  . HIS A 1 37  ? 157.545 227.078 311.969 1.00 90.84  ? 37  HIS A CA  1 
ATOM   84   C C   . HIS A 1 37  ? 158.383 225.816 312.157 1.00 91.51  ? 37  HIS A C   1 
ATOM   85   O O   . HIS A 1 37  ? 157.819 224.728 312.322 1.00 90.86  ? 37  HIS A O   1 
ATOM   86   C CB  . HIS A 1 37  ? 156.247 226.728 311.233 1.00 90.82  ? 37  HIS A CB  1 
ATOM   87   C CG  . HIS A 1 37  ? 155.036 226.713 312.113 1.00 92.06  ? 37  HIS A CG  1 
ATOM   88   N ND1 . HIS A 1 37  ? 154.475 227.862 312.628 1.00 88.25  ? 37  HIS A ND1 1 
ATOM   89   C CD2 . HIS A 1 37  ? 154.273 225.689 312.563 1.00 92.46  ? 37  HIS A CD2 1 
ATOM   90   C CE1 . HIS A 1 37  ? 153.421 227.546 313.358 1.00 89.90  ? 37  HIS A CE1 1 
ATOM   91   N NE2 . HIS A 1 37  ? 153.277 226.234 313.335 1.00 91.23  ? 37  HIS A NE2 1 
ATOM   92   N N   . SER A 1 38  ? 159.709 225.933 312.148 1.00 100.31 ? 38  SER A N   1 
ATOM   93   C CA  . SER A 1 38  ? 160.579 224.769 312.170 1.00 103.14 ? 38  SER A CA  1 
ATOM   94   C C   . SER A 1 38  ? 160.756 224.252 313.596 1.00 104.56 ? 38  SER A C   1 
ATOM   95   O O   . SER A 1 38  ? 160.152 224.748 314.552 1.00 103.16 ? 38  SER A O   1 
ATOM   96   C CB  . SER A 1 38  ? 161.931 225.109 311.549 1.00 104.36 ? 38  SER A CB  1 
ATOM   97   O OG  . SER A 1 38  ? 162.782 223.977 311.538 1.00 103.70 ? 38  SER A OG  1 
ATOM   98   N N   . LYS A 1 39  ? 161.604 223.229 313.736 1.00 110.21 ? 39  LYS A N   1 
ATOM   99   C CA  . LYS A 1 39  ? 161.849 222.569 315.013 1.00 109.20 ? 39  LYS A CA  1 
ATOM   100  C C   . LYS A 1 39  ? 163.310 222.667 315.441 1.00 108.67 ? 39  LYS A C   1 
ATOM   101  O O   . LYS A 1 39  ? 163.748 221.910 316.313 1.00 109.16 ? 39  LYS A O   1 
ATOM   102  C CB  . LYS A 1 39  ? 161.420 221.102 314.938 1.00 107.90 ? 39  LYS A CB  1 
ATOM   103  C CG  . LYS A 1 39  ? 159.938 220.909 314.652 1.00 108.67 ? 39  LYS A CG  1 
ATOM   104  C CD  . LYS A 1 39  ? 159.560 219.436 314.551 1.00 108.92 ? 39  LYS A CD  1 
ATOM   105  C CE  . LYS A 1 39  ? 160.099 218.790 313.280 1.00 109.85 ? 39  LYS A CE  1 
ATOM   106  N NZ  . LYS A 1 39  ? 159.546 219.414 312.046 1.00 108.42 ? 39  LYS A NZ  1 
ATOM   107  N N   . GLU A 1 40  ? 164.077 223.584 314.845 1.00 111.93 ? 40  GLU A N   1 
ATOM   108  C CA  . GLU A 1 40  ? 165.476 223.738 315.233 1.00 113.25 ? 40  GLU A CA  1 
ATOM   109  C C   . GLU A 1 40  ? 165.609 224.311 316.639 1.00 116.09 ? 40  GLU A C   1 
ATOM   110  O O   . GLU A 1 40  ? 166.588 224.018 317.334 1.00 115.94 ? 40  GLU A O   1 
ATOM   111  C CB  . GLU A 1 40  ? 166.201 224.631 314.227 1.00 112.79 ? 40  GLU A CB  1 
ATOM   112  C CG  . GLU A 1 40  ? 167.699 224.734 314.457 1.00 113.97 ? 40  GLU A CG  1 
ATOM   113  C CD  . GLU A 1 40  ? 168.358 225.749 313.548 1.00 113.49 ? 40  GLU A CD  1 
ATOM   114  O OE1 . GLU A 1 40  ? 167.753 226.104 312.515 1.00 112.79 ? 40  GLU A OE1 1 
ATOM   115  O OE2 . GLU A 1 40  ? 169.479 226.196 313.870 1.00 112.94 ? 40  GLU A OE2 1 
ATOM   116  N N   . ILE A 1 41  ? 164.650 225.132 317.058 1.00 114.72 ? 41  ILE A N   1 
ATOM   117  C CA  . ILE A 1 41  ? 164.590 225.732 318.393 1.00 112.63 ? 41  ILE A CA  1 
ATOM   118  C C   . ILE A 1 41  ? 165.933 226.333 318.799 1.00 112.65 ? 41  ILE A C   1 
ATOM   119  O O   . ILE A 1 41  ? 166.425 226.059 319.903 1.00 114.35 ? 41  ILE A O   1 
ATOM   120  C CB  . ILE A 1 41  ? 164.099 224.711 319.436 1.00 111.55 ? 41  ILE A CB  1 
ATOM   121  C CG1 . ILE A 1 41  ? 165.132 223.606 319.712 1.00 110.54 ? 41  ILE A CG1 1 
ATOM   122  C CG2 . ILE A 1 41  ? 162.788 224.087 318.966 1.00 110.15 ? 41  ILE A CG2 1 
ATOM   123  C CD1 . ILE A 1 41  ? 165.093 223.098 321.138 1.00 107.60 ? 41  ILE A CD1 1 
ATOM   124  N N   . PRO A 1 42  ? 166.538 227.192 317.978 1.00 109.35 ? 42  PRO A N   1 
ATOM   125  C CA  . PRO A 1 42  ? 167.811 227.807 318.384 1.00 108.25 ? 42  PRO A CA  1 
ATOM   126  C C   . PRO A 1 42  ? 167.698 228.652 319.640 1.00 108.53 ? 42  PRO A C   1 
ATOM   127  O O   . PRO A 1 42  ? 168.718 228.897 320.297 1.00 109.15 ? 42  PRO A O   1 
ATOM   128  C CB  . PRO A 1 42  ? 168.196 228.657 317.166 1.00 107.99 ? 42  PRO A CB  1 
ATOM   129  C CG  . PRO A 1 42  ? 166.906 228.931 316.470 1.00 106.76 ? 42  PRO A CG  1 
ATOM   130  C CD  . PRO A 1 42  ? 166.056 227.716 316.688 1.00 108.46 ? 42  PRO A CD  1 
ATOM   131  N N   . ALA A 1 43  ? 166.493 229.103 319.999 1.00 103.87 ? 43  ALA A N   1 
ATOM   132  C CA  . ALA A 1 43  ? 166.343 229.964 321.167 1.00 102.60 ? 43  ALA A CA  1 
ATOM   133  C C   . ALA A 1 43  ? 166.764 229.249 322.444 1.00 104.61 ? 43  ALA A C   1 
ATOM   134  O O   . ALA A 1 43  ? 167.451 229.831 323.290 1.00 105.37 ? 43  ALA A O   1 
ATOM   135  C CB  . ALA A 1 43  ? 164.897 230.444 321.280 1.00 102.84 ? 43  ALA A CB  1 
ATOM   136  N N   . LEU A 1 44  ? 166.361 227.992 322.603 1.00 110.13 ? 44  LEU A N   1 
ATOM   137  C CA  . LEU A 1 44  ? 166.695 227.235 323.802 1.00 106.56 ? 44  LEU A CA  1 
ATOM   138  C C   . LEU A 1 44  ? 168.092 226.644 323.682 1.00 106.35 ? 44  LEU A C   1 
ATOM   139  O O   . LEU A 1 44  ? 168.452 226.077 322.645 1.00 106.65 ? 44  LEU A O   1 
ATOM   140  C CB  . LEU A 1 44  ? 165.674 226.123 324.039 1.00 104.06 ? 44  LEU A CB  1 
ATOM   141  C CG  . LEU A 1 44  ? 164.419 226.524 324.813 1.00 105.04 ? 44  LEU A CG  1 
ATOM   142  C CD1 . LEU A 1 44  ? 163.581 227.511 324.025 1.00 105.40 ? 44  LEU A CD1 1 
ATOM   143  C CD2 . LEU A 1 44  ? 163.612 225.291 325.163 1.00 103.23 ? 44  LEU A CD2 1 
ATOM   144  N N   . THR A 1 45  ? 168.876 226.777 324.747 1.00 117.99 ? 45  THR A N   1 
ATOM   145  C CA  . THR A 1 45  ? 170.235 226.256 324.792 1.00 119.25 ? 45  THR A CA  1 
ATOM   146  C C   . THR A 1 45  ? 170.474 225.676 326.183 1.00 118.46 ? 45  THR A C   1 
ATOM   147  O O   . THR A 1 45  ? 169.543 225.507 326.976 1.00 116.97 ? 45  THR A O   1 
ATOM   148  C CB  . THR A 1 45  ? 171.250 227.354 324.445 1.00 118.68 ? 45  THR A CB  1 
ATOM   149  O OG1 . THR A 1 45  ? 172.564 226.788 324.360 1.00 117.13 ? 45  THR A OG1 1 
ATOM   150  C CG2 . THR A 1 45  ? 171.238 228.449 325.503 1.00 116.88 ? 45  THR A CG2 1 
ATOM   151  N N   . ALA A 1 46  ? 171.732 225.350 326.472 1.00 120.47 ? 46  ALA A N   1 
ATOM   152  C CA  . ALA A 1 46  ? 172.143 224.877 327.787 1.00 118.68 ? 46  ALA A CA  1 
ATOM   153  C C   . ALA A 1 46  ? 173.407 225.615 328.195 1.00 121.34 ? 46  ALA A C   1 
ATOM   154  O O   . ALA A 1 46  ? 174.444 225.491 327.533 1.00 119.64 ? 46  ALA A O   1 
ATOM   155  C CB  . ALA A 1 46  ? 172.374 223.365 327.784 1.00 116.02 ? 46  ALA A CB  1 
ATOM   156  N N   . VAL A 1 47  ? 173.319 226.387 329.282 1.00 122.58 ? 47  VAL A N   1 
ATOM   157  C CA  . VAL A 1 47  ? 174.469 227.148 329.768 1.00 121.44 ? 47  VAL A CA  1 
ATOM   158  C C   . VAL A 1 47  ? 175.459 226.279 330.520 1.00 120.04 ? 47  VAL A C   1 
ATOM   159  O O   . VAL A 1 47  ? 176.546 226.754 330.868 1.00 120.98 ? 47  VAL A O   1 
ATOM   160  C CB  . VAL A 1 47  ? 174.000 228.304 330.674 1.00 119.48 ? 47  VAL A CB  1 
ATOM   161  C CG1 . VAL A 1 47  ? 175.192 229.093 331.192 1.00 119.02 ? 47  VAL A CG1 1 
ATOM   162  C CG2 . VAL A 1 47  ? 173.055 229.222 329.914 1.00 119.51 ? 47  VAL A CG2 1 
ATOM   163  N N   . GLU A 1 48  ? 175.127 225.009 330.759 1.00 113.28 ? 48  GLU A N   1 
ATOM   164  C CA  . GLU A 1 48  ? 176.023 224.146 331.518 1.00 111.73 ? 48  GLU A CA  1 
ATOM   165  C C   . GLU A 1 48  ? 177.384 224.045 330.841 1.00 113.52 ? 48  GLU A C   1 
ATOM   166  O O   . GLU A 1 48  ? 178.426 224.125 331.500 1.00 112.60 ? 48  GLU A O   1 
ATOM   167  C CB  . GLU A 1 48  ? 175.387 222.770 331.707 1.00 111.69 ? 48  GLU A CB  1 
ATOM   168  C CG  . GLU A 1 48  ? 174.251 222.758 332.722 1.00 114.35 ? 48  GLU A CG  1 
ATOM   169  C CD  . GLU A 1 48  ? 173.035 223.525 332.248 1.00 114.59 ? 48  GLU A CD  1 
ATOM   170  O OE1 . GLU A 1 48  ? 172.928 223.777 331.032 1.00 115.63 ? 48  GLU A OE1 1 
ATOM   171  O OE2 . GLU A 1 48  ? 172.181 223.877 333.091 1.00 111.77 ? 48  GLU A OE2 1 
ATOM   172  N N   . THR A 1 49  ? 177.396 223.877 329.524 1.00 112.55 ? 49  THR A N   1 
ATOM   173  C CA  . THR A 1 49  ? 178.646 223.956 328.787 1.00 112.42 ? 49  THR A CA  1 
ATOM   174  C C   . THR A 1 49  ? 179.227 225.364 328.910 1.00 111.53 ? 49  THR A C   1 
ATOM   175  O O   . THR A 1 49  ? 178.577 226.297 329.378 1.00 109.92 ? 49  THR A O   1 
ATOM   176  C CB  . THR A 1 49  ? 178.433 223.587 327.316 1.00 111.46 ? 49  THR A CB  1 
ATOM   177  O OG1 . THR A 1 49  ? 179.687 223.614 326.622 1.00 106.89 ? 49  THR A OG1 1 
ATOM   178  C CG2 . THR A 1 49  ? 177.468 224.561 326.649 1.00 112.17 ? 49  THR A CG2 1 
ATOM   179  N N   . GLY A 1 50  ? 180.476 225.510 328.481 1.00 111.55 ? 50  GLY A N   1 
ATOM   180  C CA  . GLY A 1 50  ? 181.164 226.782 328.607 1.00 112.25 ? 50  GLY A CA  1 
ATOM   181  C C   . GLY A 1 50  ? 181.103 227.630 327.354 1.00 111.79 ? 50  GLY A C   1 
ATOM   182  O O   . GLY A 1 50  ? 181.920 228.539 327.176 1.00 109.45 ? 50  GLY A O   1 
ATOM   183  N N   . ALA A 1 51  ? 180.142 227.347 326.477 1.00 113.37 ? 51  ALA A N   1 
ATOM   184  C CA  . ALA A 1 51  ? 179.994 228.054 325.212 1.00 112.62 ? 51  ALA A CA  1 
ATOM   185  C C   . ALA A 1 51  ? 178.760 228.943 325.277 1.00 113.64 ? 51  ALA A C   1 
ATOM   186  O O   . ALA A 1 51  ? 177.658 228.461 325.563 1.00 113.45 ? 51  ALA A O   1 
ATOM   187  C CB  . ALA A 1 51  ? 179.887 227.072 324.046 1.00 112.98 ? 51  ALA A CB  1 
ATOM   188  N N   . THR A 1 52  ? 178.948 230.233 325.014 1.00 118.47 ? 52  THR A N   1 
ATOM   189  C CA  . THR A 1 52  ? 177.834 231.168 324.993 1.00 119.15 ? 52  THR A CA  1 
ATOM   190  C C   . THR A 1 52  ? 176.994 230.963 323.737 1.00 118.32 ? 52  THR A C   1 
ATOM   191  O O   . THR A 1 52  ? 177.481 230.499 322.703 1.00 115.66 ? 52  THR A O   1 
ATOM   192  C CB  . THR A 1 52  ? 178.346 232.609 325.058 1.00 116.78 ? 52  THR A CB  1 
ATOM   193  O OG1 . THR A 1 52  ? 179.114 232.792 326.254 1.00 115.10 ? 52  THR A OG1 1 
ATOM   194  C CG2 . THR A 1 52  ? 177.191 233.601 325.048 1.00 115.71 ? 52  THR A CG2 1 
ATOM   195  N N   . ASN A 1 53  ? 175.720 231.312 323.838 1.00 118.07 ? 53  ASN A N   1 
ATOM   196  C CA  . ASN A 1 53  ? 174.795 231.124 322.727 1.00 116.78 ? 53  ASN A CA  1 
ATOM   197  C C   . ASN A 1 53  ? 175.085 232.141 321.629 1.00 117.22 ? 53  ASN A C   1 
ATOM   198  O O   . ASN A 1 53  ? 175.026 233.349 321.891 1.00 114.28 ? 53  ASN A O   1 
ATOM   199  C CB  . ASN A 1 53  ? 173.359 231.268 323.222 1.00 116.72 ? 53  ASN A CB  1 
ATOM   200  C CG  . ASN A 1 53  ? 172.342 230.746 322.227 1.00 116.96 ? 53  ASN A CG  1 
ATOM   201  O OD1 . ASN A 1 53  ? 172.692 230.072 321.260 1.00 116.46 ? 53  ASN A OD1 1 
ATOM   202  N ND2 . ASN A 1 53  ? 171.072 231.050 322.467 1.00 113.98 ? 53  ASN A ND2 1 
ATOM   203  N N   . PRO A 1 54  ? 175.395 231.718 320.402 1.00 113.16 ? 54  PRO A N   1 
ATOM   204  C CA  . PRO A 1 54  ? 175.614 232.677 319.313 1.00 112.11 ? 54  PRO A CA  1 
ATOM   205  C C   . PRO A 1 54  ? 174.340 233.237 318.700 1.00 112.17 ? 54  PRO A C   1 
ATOM   206  O O   . PRO A 1 54  ? 174.410 233.856 317.635 1.00 111.71 ? 54  PRO A O   1 
ATOM   207  C CB  . PRO A 1 54  ? 176.388 231.839 318.283 1.00 109.48 ? 54  PRO A CB  1 
ATOM   208  C CG  . PRO A 1 54  ? 175.889 230.465 318.488 1.00 109.38 ? 54  PRO A CG  1 
ATOM   209  C CD  . PRO A 1 54  ? 175.633 230.331 319.963 1.00 109.84 ? 54  PRO A CD  1 
ATOM   210  N N   . LEU A 1 55  ? 173.195 233.030 319.346 1.00 109.32 ? 55  LEU A N   1 
ATOM   211  C CA  . LEU A 1 55  ? 171.918 233.496 318.826 1.00 106.88 ? 55  LEU A CA  1 
ATOM   212  C C   . LEU A 1 55  ? 172.006 234.959 318.406 1.00 107.54 ? 55  LEU A C   1 
ATOM   213  O O   . LEU A 1 55  ? 172.767 235.747 318.974 1.00 108.41 ? 55  LEU A O   1 
ATOM   214  C CB  . LEU A 1 55  ? 170.839 233.313 319.893 1.00 104.03 ? 55  LEU A CB  1 
ATOM   215  C CG  . LEU A 1 55  ? 169.376 233.400 319.470 1.00 105.52 ? 55  LEU A CG  1 
ATOM   216  C CD1 . LEU A 1 55  ? 169.012 232.266 318.529 1.00 108.50 ? 55  LEU A CD1 1 
ATOM   217  C CD2 . LEU A 1 55  ? 168.499 233.371 320.702 1.00 107.46 ? 55  LEU A CD2 1 
ATOM   218  N N   . VAL A 1 56  ? 171.217 235.317 317.397 1.00 103.86 ? 56  VAL A N   1 
ATOM   219  C CA  . VAL A 1 56  ? 171.192 236.681 316.871 1.00 101.44 ? 56  VAL A CA  1 
ATOM   220  C C   . VAL A 1 56  ? 169.740 237.132 316.782 1.00 105.48 ? 56  VAL A C   1 
ATOM   221  O O   . VAL A 1 56  ? 168.814 236.306 316.814 1.00 107.06 ? 56  VAL A O   1 
ATOM   222  C CB  . VAL A 1 56  ? 171.892 236.777 315.495 1.00 99.76  ? 56  VAL A CB  1 
ATOM   223  C CG1 . VAL A 1 56  ? 173.289 236.186 315.568 1.00 102.58 ? 56  VAL A CG1 1 
ATOM   224  C CG2 . VAL A 1 56  ? 171.073 236.080 314.427 1.00 102.98 ? 56  VAL A CG2 1 
ATOM   225  N N   . PRO A 1 57  ? 169.506 238.444 316.676 1.00 100.97 ? 57  PRO A N   1 
ATOM   226  C CA  . PRO A 1 57  ? 168.120 238.943 316.722 1.00 98.84  ? 57  PRO A CA  1 
ATOM   227  C C   . PRO A 1 57  ? 167.227 238.366 315.641 1.00 101.41 ? 57  PRO A C   1 
ATOM   228  O O   . PRO A 1 57  ? 166.025 238.188 315.875 1.00 99.63  ? 57  PRO A O   1 
ATOM   229  C CB  . PRO A 1 57  ? 168.288 240.460 316.559 1.00 95.69  ? 57  PRO A CB  1 
ATOM   230  C CG  . PRO A 1 57  ? 169.696 240.737 316.937 1.00 98.23  ? 57  PRO A CG  1 
ATOM   231  C CD  . PRO A 1 57  ? 170.475 239.539 316.510 1.00 98.54  ? 57  PRO A CD  1 
ATOM   232  N N   . SER A 1 58  ? 167.772 238.074 314.460 1.00 107.22 ? 58  SER A N   1 
ATOM   233  C CA  . SER A 1 58  ? 166.953 237.540 313.380 1.00 106.23 ? 58  SER A CA  1 
ATOM   234  C C   . SER A 1 58  ? 166.308 236.213 313.749 1.00 105.92 ? 58  SER A C   1 
ATOM   235  O O   . SER A 1 58  ? 165.273 235.858 313.174 1.00 105.66 ? 58  SER A O   1 
ATOM   236  C CB  . SER A 1 58  ? 167.800 237.369 312.120 1.00 102.39 ? 58  SER A CB  1 
ATOM   237  O OG  . SER A 1 58  ? 168.816 236.403 312.318 1.00 102.34 ? 58  SER A OG  1 
ATOM   238  N N   . ASP A 1 59  ? 166.889 235.474 314.695 1.00 107.42 ? 59  ASP A N   1 
ATOM   239  C CA  . ASP A 1 59  ? 166.405 234.132 314.993 1.00 107.28 ? 59  ASP A CA  1 
ATOM   240  C C   . ASP A 1 59  ? 165.118 234.149 315.813 1.00 108.34 ? 59  ASP A C   1 
ATOM   241  O O   . ASP A 1 59  ? 164.238 233.309 315.599 1.00 107.78 ? 59  ASP A O   1 
ATOM   242  C CB  . ASP A 1 59  ? 167.491 233.344 315.724 1.00 107.12 ? 59  ASP A CB  1 
ATOM   243  C CG  . ASP A 1 59  ? 168.726 233.133 314.872 1.00 108.69 ? 59  ASP A CG  1 
ATOM   244  O OD1 . ASP A 1 59  ? 168.592 233.100 313.631 1.00 108.55 ? 59  ASP A OD1 1 
ATOM   245  O OD2 . ASP A 1 59  ? 169.830 233.000 315.438 1.00 108.42 ? 59  ASP A OD2 1 
ATOM   246  N N   . THR A 1 60  ? 164.986 235.088 316.750 1.00 109.29 ? 60  THR A N   1 
ATOM   247  C CA  . THR A 1 60  ? 163.862 235.106 317.679 1.00 111.05 ? 60  THR A CA  1 
ATOM   248  C C   . THR A 1 60  ? 162.870 236.230 317.404 1.00 106.95 ? 60  THR A C   1 
ATOM   249  O O   . THR A 1 60  ? 161.940 236.424 318.193 1.00 104.37 ? 60  THR A O   1 
ATOM   250  C CB  . THR A 1 60  ? 164.371 235.216 319.118 1.00 110.20 ? 60  THR A CB  1 
ATOM   251  O OG1 . THR A 1 60  ? 165.261 236.334 319.231 1.00 107.25 ? 60  THR A OG1 1 
ATOM   252  C CG2 . THR A 1 60  ? 165.094 233.945 319.529 1.00 104.49 ? 60  THR A CG2 1 
ATOM   253  N N   . VAL A 1 61  ? 163.039 236.973 316.311 1.00 101.51 ? 61  VAL A N   1 
ATOM   254  C CA  . VAL A 1 61  ? 162.161 238.093 315.994 1.00 101.32 ? 61  VAL A CA  1 
ATOM   255  C C   . VAL A 1 61  ? 162.121 238.257 314.483 1.00 101.69 ? 61  VAL A C   1 
ATOM   256  O O   . VAL A 1 61  ? 163.077 237.922 313.780 1.00 101.44 ? 61  VAL A O   1 
ATOM   257  C CB  . VAL A 1 61  ? 162.632 239.401 316.677 1.00 99.84  ? 61  VAL A CB  1 
ATOM   258  C CG1 . VAL A 1 61  ? 161.806 240.587 316.199 1.00 98.04  ? 61  VAL A CG1 1 
ATOM   259  C CG2 . VAL A 1 61  ? 162.559 239.276 318.191 1.00 100.30 ? 61  VAL A CG2 1 
ATOM   260  N N   . GLN A 1 62  ? 160.999 238.773 313.983 1.00 96.00  ? 62  GLN A N   1 
ATOM   261  C CA  . GLN A 1 62  ? 160.912 239.169 312.582 1.00 94.59  ? 62  GLN A CA  1 
ATOM   262  C C   . GLN A 1 62  ? 161.760 240.415 312.375 1.00 92.79  ? 62  GLN A C   1 
ATOM   263  O O   . GLN A 1 62  ? 161.440 241.488 312.897 1.00 92.22  ? 62  GLN A O   1 
ATOM   264  C CB  . GLN A 1 62  ? 159.464 239.421 312.179 1.00 94.11  ? 62  GLN A CB  1 
ATOM   265  C CG  . GLN A 1 62  ? 158.747 238.191 311.650 1.00 93.64  ? 62  GLN A CG  1 
ATOM   266  C CD  . GLN A 1 62  ? 157.440 238.526 310.962 1.00 92.51  ? 62  GLN A CD  1 
ATOM   267  O OE1 . GLN A 1 62  ? 156.400 237.944 311.265 1.00 91.00  ? 62  GLN A OE1 1 
ATOM   268  N NE2 . GLN A 1 62  ? 157.488 239.465 310.025 1.00 94.80  ? 62  GLN A NE2 1 
ATOM   269  N N   . THR A 1 63  ? 162.841 240.275 311.617 1.00 95.71  ? 63  THR A N   1 
ATOM   270  C CA  . THR A 1 63  ? 163.839 241.320 311.459 1.00 94.47  ? 63  THR A CA  1 
ATOM   271  C C   . THR A 1 63  ? 163.862 241.810 310.019 1.00 97.87  ? 63  THR A C   1 
ATOM   272  O O   . THR A 1 63  ? 163.719 241.019 309.082 1.00 99.53  ? 63  THR A O   1 
ATOM   273  C CB  . THR A 1 63  ? 165.223 240.806 311.856 1.00 93.63  ? 63  THR A CB  1 
ATOM   274  O OG1 . THR A 1 63  ? 165.211 240.416 313.234 1.00 96.86  ? 63  THR A OG1 1 
ATOM   275  C CG2 . THR A 1 63  ? 166.269 241.875 311.652 1.00 97.43  ? 63  THR A CG2 1 
ATOM   276  N N   . ARG A 1 64  ? 164.039 243.117 309.851 1.00 95.67  ? 64  ARG A N   1 
ATOM   277  C CA  . ARG A 1 64  ? 164.137 243.729 308.536 1.00 94.00  ? 64  ARG A CA  1 
ATOM   278  C C   . ARG A 1 64  ? 165.597 243.918 308.150 1.00 95.54  ? 64  ARG A C   1 
ATOM   279  O O   . ARG A 1 64  ? 166.463 244.123 309.004 1.00 98.16  ? 64  ARG A O   1 
ATOM   280  C CB  . ARG A 1 64  ? 163.419 245.078 308.500 1.00 93.85  ? 64  ARG A CB  1 
ATOM   281  C CG  . ARG A 1 64  ? 163.515 245.776 307.152 1.00 98.01  ? 64  ARG A CG  1 
ATOM   282  C CD  . ARG A 1 64  ? 162.694 247.045 307.107 1.00 98.27  ? 64  ARG A CD  1 
ATOM   283  N NE  . ARG A 1 64  ? 162.997 247.924 308.229 1.00 97.93  ? 64  ARG A NE  1 
ATOM   284  C CZ  . ARG A 1 64  ? 163.991 248.800 308.244 1.00 93.22  ? 64  ARG A CZ  1 
ATOM   285  N NH1 . ARG A 1 64  ? 164.804 248.938 307.210 1.00 92.10  ? 64  ARG A NH1 1 
ATOM   286  N NH2 . ARG A 1 64  ? 164.175 249.554 309.324 1.00 94.20  ? 64  ARG A NH2 1 
ATOM   287  N N   . HIS A 1 65  ? 165.861 243.851 306.848 1.00 99.18  ? 65  HIS A N   1 
ATOM   288  C CA  . HIS A 1 65  ? 167.213 244.059 306.352 1.00 100.32 ? 65  HIS A CA  1 
ATOM   289  C C   . HIS A 1 65  ? 167.723 245.430 306.778 1.00 100.26 ? 65  HIS A C   1 
ATOM   290  O O   . HIS A 1 65  ? 166.992 246.423 306.739 1.00 100.18 ? 65  HIS A O   1 
ATOM   291  C CB  . HIS A 1 65  ? 167.241 243.937 304.830 1.00 99.25  ? 65  HIS A CB  1 
ATOM   292  C CG  . HIS A 1 65  ? 168.617 243.985 304.246 1.00 100.46 ? 65  HIS A CG  1 
ATOM   293  N ND1 . HIS A 1 65  ? 168.903 244.639 303.067 1.00 100.14 ? 65  HIS A ND1 1 
ATOM   294  C CD2 . HIS A 1 65  ? 169.787 243.455 304.675 1.00 101.25 ? 65  HIS A CD2 1 
ATOM   295  C CE1 . HIS A 1 65  ? 170.190 244.514 302.797 1.00 100.14 ? 65  HIS A CE1 1 
ATOM   296  N NE2 . HIS A 1 65  ? 170.749 243.798 303.757 1.00 102.92 ? 65  HIS A NE2 1 
ATOM   297  N N   . VAL A 1 66  ? 168.986 245.478 307.194 1.00 95.78  ? 66  VAL A N   1 
ATOM   298  C CA  . VAL A 1 66  ? 169.601 246.721 307.642 1.00 93.26  ? 66  VAL A CA  1 
ATOM   299  C C   . VAL A 1 66  ? 171.071 246.727 307.249 1.00 94.55  ? 66  VAL A C   1 
ATOM   300  O O   . VAL A 1 66  ? 171.843 245.864 307.679 1.00 95.50  ? 66  VAL A O   1 
ATOM   301  C CB  . VAL A 1 66  ? 169.438 246.905 309.161 1.00 92.49  ? 66  VAL A CB  1 
ATOM   302  C CG1 . VAL A 1 66  ? 170.330 248.029 309.663 1.00 93.05  ? 66  VAL A CG1 1 
ATOM   303  C CG2 . VAL A 1 66  ? 167.987 247.176 309.510 1.00 95.08  ? 66  VAL A CG2 1 
ATOM   304  N N   . VAL A 1 67  ? 171.467 247.698 306.427 1.00 93.96  ? 67  VAL A N   1 
ATOM   305  C CA  . VAL A 1 67  ? 172.878 247.874 306.108 1.00 94.20  ? 67  VAL A CA  1 
ATOM   306  C C   . VAL A 1 67  ? 173.597 248.395 307.343 1.00 92.78  ? 67  VAL A C   1 
ATOM   307  O O   . VAL A 1 67  ? 173.147 249.353 307.985 1.00 91.28  ? 67  VAL A O   1 
ATOM   308  C CB  . VAL A 1 67  ? 173.047 248.825 304.915 1.00 94.70  ? 67  VAL A CB  1 
ATOM   309  C CG1 . VAL A 1 67  ? 174.521 249.054 304.623 1.00 94.51  ? 67  VAL A CG1 1 
ATOM   310  C CG2 . VAL A 1 67  ? 172.340 248.267 303.690 1.00 92.60  ? 67  VAL A CG2 1 
ATOM   311  N N   . GLN A 1 68  ? 174.716 247.766 307.683 1.00 93.25  ? 68  GLN A N   1 
ATOM   312  C CA  . GLN A 1 68  ? 175.406 248.020 308.940 1.00 92.52  ? 68  GLN A CA  1 
ATOM   313  C C   . GLN A 1 68  ? 176.583 248.954 308.697 1.00 91.33  ? 68  GLN A C   1 
ATOM   314  O O   . GLN A 1 68  ? 177.444 248.671 307.857 1.00 90.42  ? 68  GLN A O   1 
ATOM   315  C CB  . GLN A 1 68  ? 175.883 246.711 309.567 1.00 94.17  ? 68  GLN A CB  1 
ATOM   316  C CG  . GLN A 1 68  ? 176.313 246.842 311.012 1.00 90.67  ? 68  GLN A CG  1 
ATOM   317  C CD  . GLN A 1 68  ? 175.191 247.327 311.902 1.00 92.86  ? 68  GLN A CD  1 
ATOM   318  O OE1 . GLN A 1 68  ? 175.358 248.274 312.668 1.00 93.08  ? 68  GLN A OE1 1 
ATOM   319  N NE2 . GLN A 1 68  ? 174.036 246.681 311.805 1.00 92.85  ? 68  GLN A NE2 1 
ATOM   320  N N   . HIS A 1 69  ? 176.617 250.063 309.435 1.00 88.26  ? 69  HIS A N   1 
ATOM   321  C CA  . HIS A 1 69  ? 177.702 251.029 309.355 1.00 88.30  ? 69  HIS A CA  1 
ATOM   322  C C   . HIS A 1 69  ? 178.588 251.047 310.589 1.00 86.94  ? 69  HIS A C   1 
ATOM   323  O O   . HIS A 1 69  ? 179.751 251.439 310.491 1.00 86.80  ? 69  HIS A O   1 
ATOM   324  C CB  . HIS A 1 69  ? 177.141 252.441 309.140 1.00 84.65  ? 69  HIS A CB  1 
ATOM   325  C CG  . HIS A 1 69  ? 176.191 252.548 307.988 1.00 85.81  ? 69  HIS A CG  1 
ATOM   326  N ND1 . HIS A 1 69  ? 176.594 252.430 306.676 1.00 87.01  ? 69  HIS A ND1 1 
ATOM   327  C CD2 . HIS A 1 69  ? 174.857 252.778 307.953 1.00 85.76  ? 69  HIS A CD2 1 
ATOM   328  C CE1 . HIS A 1 69  ? 175.548 252.575 305.882 1.00 85.50  ? 69  HIS A CE1 1 
ATOM   329  N NE2 . HIS A 1 69  ? 174.482 252.787 306.631 1.00 84.81  ? 69  HIS A NE2 1 
ATOM   330  N N   . ARG A 1 70  ? 178.068 250.632 311.741 1.00 78.36  ? 70  ARG A N   1 
ATOM   331  C CA  . ARG A 1 70  ? 178.826 250.721 312.980 1.00 76.16  ? 70  ARG A CA  1 
ATOM   332  C C   . ARG A 1 70  ? 180.068 249.841 312.922 1.00 76.68  ? 70  ARG A C   1 
ATOM   333  O O   . ARG A 1 70  ? 180.050 248.745 312.358 1.00 79.32  ? 70  ARG A O   1 
ATOM   334  C CB  . ARG A 1 70  ? 177.944 250.314 314.161 1.00 77.53  ? 70  ARG A CB  1 
ATOM   335  C CG  . ARG A 1 70  ? 176.900 251.354 314.528 1.00 75.47  ? 70  ARG A CG  1 
ATOM   336  C CD  . ARG A 1 70  ? 176.085 250.947 315.746 1.00 74.75  ? 70  ARG A CD  1 
ATOM   337  N NE  . ARG A 1 70  ? 175.089 249.931 315.430 1.00 74.63  ? 70  ARG A NE  1 
ATOM   338  C CZ  . ARG A 1 70  ? 175.292 248.622 315.500 1.00 78.96  ? 70  ARG A CZ  1 
ATOM   339  N NH1 . ARG A 1 70  ? 176.458 248.120 315.872 1.00 82.46  ? 70  ARG A NH1 1 
ATOM   340  N NH2 . ARG A 1 70  ? 174.300 247.795 315.184 1.00 80.23  ? 70  ARG A NH2 1 
ATOM   341  N N   . SER A 1 71  ? 181.153 250.333 313.516 1.00 79.69  ? 71  SER A N   1 
ATOM   342  C CA  . SER A 1 71  ? 182.419 249.619 313.570 1.00 81.53  ? 71  SER A CA  1 
ATOM   343  C C   . SER A 1 71  ? 182.946 249.629 314.996 1.00 80.21  ? 71  SER A C   1 
ATOM   344  O O   . SER A 1 71  ? 182.682 250.557 315.766 1.00 82.79  ? 71  SER A O   1 
ATOM   345  C CB  . SER A 1 71  ? 183.458 250.245 312.634 1.00 83.56  ? 71  SER A CB  1 
ATOM   346  O OG  . SER A 1 71  ? 183.790 251.558 313.049 1.00 81.16  ? 71  SER A OG  1 
ATOM   347  N N   . ARG A 1 72  ? 183.701 248.587 315.341 1.00 66.10  ? 72  ARG A N   1 
ATOM   348  C CA  . ARG A 1 72  ? 184.250 248.426 316.679 1.00 63.10  ? 72  ARG A CA  1 
ATOM   349  C C   . ARG A 1 72  ? 185.654 249.002 316.813 1.00 68.28  ? 72  ARG A C   1 
ATOM   350  O O   . ARG A 1 72  ? 186.391 248.607 317.723 1.00 69.64  ? 72  ARG A O   1 
ATOM   351  C CB  . ARG A 1 72  ? 184.258 246.947 317.067 1.00 63.37  ? 72  ARG A CB  1 
ATOM   352  C CG  . ARG A 1 72  ? 182.879 246.339 317.237 1.00 67.85  ? 72  ARG A CG  1 
ATOM   353  C CD  . ARG A 1 72  ? 182.968 244.848 317.507 1.00 67.26  ? 72  ARG A CD  1 
ATOM   354  N NE  . ARG A 1 72  ? 181.731 244.312 318.061 1.00 63.48  ? 72  ARG A NE  1 
ATOM   355  C CZ  . ARG A 1 72  ? 181.541 243.037 318.371 1.00 67.59  ? 72  ARG A CZ  1 
ATOM   356  N NH1 . ARG A 1 72  ? 182.482 242.129 318.175 1.00 69.12  ? 72  ARG A NH1 1 
ATOM   357  N NH2 . ARG A 1 72  ? 180.377 242.664 318.893 1.00 71.44  ? 72  ARG A NH2 1 
ATOM   358  N N   . SER A 1 73  ? 186.038 249.929 315.934 1.00 64.87  ? 73  SER A N   1 
ATOM   359  C CA  . SER A 1 73  ? 187.406 250.439 315.948 1.00 57.27  ? 73  SER A CA  1 
ATOM   360  C C   . SER A 1 73  ? 187.724 251.153 317.255 1.00 55.94  ? 73  SER A C   1 
ATOM   361  O O   . SER A 1 73  ? 188.804 250.964 317.825 1.00 56.67  ? 73  SER A O   1 
ATOM   362  C CB  . SER A 1 73  ? 187.621 251.378 314.763 1.00 65.30  ? 73  SER A CB  1 
ATOM   363  O OG  . SER A 1 73  ? 186.690 252.445 314.787 1.00 66.03  ? 73  SER A OG  1 
ATOM   364  N N   . GLU A 1 74  ? 186.799 251.979 317.747 1.00 60.78  ? 74  GLU A N   1 
ATOM   365  C CA  . GLU A 1 74  ? 187.059 252.740 318.963 1.00 61.13  ? 74  GLU A CA  1 
ATOM   366  C C   . GLU A 1 74  ? 187.294 251.839 320.168 1.00 55.46  ? 74  GLU A C   1 
ATOM   367  O O   . GLU A 1 74  ? 187.943 252.265 321.128 1.00 51.02  ? 74  GLU A O   1 
ATOM   368  C CB  . GLU A 1 74  ? 185.890 253.688 319.245 1.00 62.04  ? 74  GLU A CB  1 
ATOM   369  C CG  . GLU A 1 74  ? 186.115 254.659 320.406 1.00 65.76  ? 74  GLU A CG  1 
ATOM   370  C CD  . GLU A 1 74  ? 187.050 255.804 320.058 1.00 72.54  ? 74  GLU A CD  1 
ATOM   371  O OE1 . GLU A 1 74  ? 187.455 255.907 318.883 1.00 72.54  ? 74  GLU A OE1 1 
ATOM   372  O OE2 . GLU A 1 74  ? 187.377 256.605 320.959 1.00 62.82  ? 74  GLU A OE2 1 
ATOM   373  N N   . SER A 1 75  ? 186.791 250.608 320.138 1.00 56.67  ? 75  SER A N   1 
ATOM   374  C CA  . SER A 1 75  ? 186.840 249.713 321.285 1.00 51.42  ? 75  SER A CA  1 
ATOM   375  C C   . SER A 1 75  ? 187.994 248.723 321.231 1.00 47.97  ? 75  SER A C   1 
ATOM   376  O O   . SER A 1 75  ? 188.092 247.864 322.111 1.00 52.97  ? 75  SER A O   1 
ATOM   377  C CB  . SER A 1 75  ? 185.523 248.944 321.402 1.00 55.68  ? 75  SER A CB  1 
ATOM   378  O OG  . SER A 1 75  ? 185.272 248.201 320.224 1.00 60.22  ? 75  SER A OG  1 
ATOM   379  N N   . SER A 1 76  ? 188.860 248.806 320.226 1.00 52.12  ? 76  SER A N   1 
ATOM   380  C CA  . SER A 1 76  ? 189.994 247.901 320.165 1.00 47.33  ? 76  SER A CA  1 
ATOM   381  C C   . SER A 1 76  ? 190.919 248.147 321.354 1.00 46.37  ? 76  SER A C   1 
ATOM   382  O O   . SER A 1 76  ? 190.755 249.097 322.121 1.00 52.08  ? 76  SER A O   1 
ATOM   383  C CB  . SER A 1 76  ? 190.748 248.074 318.849 1.00 46.69  ? 76  SER A CB  1 
ATOM   384  O OG  . SER A 1 76  ? 191.167 249.414 318.676 1.00 51.31  ? 76  SER A OG  1 
ATOM   385  N N   . ILE A 1 77  ? 191.905 247.263 321.507 1.00 46.65  ? 77  ILE A N   1 
ATOM   386  C CA  . ILE A 1 77  ? 192.805 247.365 322.651 1.00 48.40  ? 77  ILE A CA  1 
ATOM   387  C C   . ILE A 1 77  ? 193.600 248.662 322.589 1.00 56.43  ? 77  ILE A C   1 
ATOM   388  O O   . ILE A 1 77  ? 193.742 249.368 323.596 1.00 59.37  ? 77  ILE A O   1 
ATOM   389  C CB  . ILE A 1 77  ? 193.730 246.137 322.717 1.00 43.32  ? 77  ILE A CB  1 
ATOM   390  C CG1 . ILE A 1 77  ? 192.915 244.842 322.691 1.00 52.56  ? 77  ILE A CG1 1 
ATOM   391  C CG2 . ILE A 1 77  ? 194.580 246.189 323.971 1.00 40.78  ? 77  ILE A CG2 1 
ATOM   392  C CD1 . ILE A 1 77  ? 191.905 244.718 323.814 1.00 53.26  ? 77  ILE A CD1 1 
ATOM   393  N N   . GLU A 1 78  ? 194.129 249.004 321.413 1.00 65.75  ? 78  GLU A N   1 
ATOM   394  C CA  . GLU A 1 78  ? 194.892 250.240 321.287 1.00 60.16  ? 78  GLU A CA  1 
ATOM   395  C C   . GLU A 1 78  ? 194.028 251.447 321.624 1.00 56.00  ? 78  GLU A C   1 
ATOM   396  O O   . GLU A 1 78  ? 194.388 252.266 322.477 1.00 61.71  ? 78  GLU A O   1 
ATOM   397  C CB  . GLU A 1 78  ? 195.461 250.369 319.874 1.00 60.38  ? 78  GLU A CB  1 
ATOM   398  C CG  . GLU A 1 78  ? 196.653 249.473 319.593 1.00 61.18  ? 78  GLU A CG  1 
ATOM   399  C CD  . GLU A 1 78  ? 196.275 248.012 319.488 1.00 69.36  ? 78  GLU A CD  1 
ATOM   400  O OE1 . GLU A 1 78  ? 195.068 247.703 319.577 1.00 69.97  ? 78  GLU A OE1 1 
ATOM   401  O OE2 . GLU A 1 78  ? 197.183 247.172 319.316 1.00 71.97  ? 78  GLU A OE2 1 
ATOM   402  N N   . SER A 1 79  ? 192.866 251.563 320.979 1.00 44.00  ? 79  SER A N   1 
ATOM   403  C CA  . SER A 1 79  ? 191.998 252.705 321.233 1.00 48.52  ? 79  SER A CA  1 
ATOM   404  C C   . SER A 1 79  ? 191.509 252.722 322.673 1.00 43.60  ? 79  SER A C   1 
ATOM   405  O O   . SER A 1 79  ? 191.187 253.789 323.207 1.00 43.61  ? 79  SER A O   1 
ATOM   406  C CB  . SER A 1 79  ? 190.813 252.684 320.272 1.00 52.77  ? 79  SER A CB  1 
ATOM   407  O OG  . SER A 1 79  ? 191.255 252.664 318.928 1.00 59.69  ? 79  SER A OG  1 
ATOM   408  N N   . PHE A 1 80  ? 191.439 251.556 323.314 1.00 39.40  ? 80  PHE A N   1 
ATOM   409  C CA  . PHE A 1 80  ? 191.049 251.508 324.716 1.00 41.27  ? 80  PHE A CA  1 
ATOM   410  C C   . PHE A 1 80  ? 192.175 251.970 325.629 1.00 49.13  ? 80  PHE A C   1 
ATOM   411  O O   . PHE A 1 80  ? 191.909 252.504 326.710 1.00 54.18  ? 80  PHE A O   1 
ATOM   412  C CB  . PHE A 1 80  ? 190.611 250.091 325.087 1.00 36.36  ? 80  PHE A CB  1 
ATOM   413  C CG  . PHE A 1 80  ? 190.051 249.973 326.475 1.00 30.91  ? 80  PHE A CG  1 
ATOM   414  C CD1 . PHE A 1 80  ? 188.936 250.697 326.848 1.00 44.06  ? 80  PHE A CD1 1 
ATOM   415  C CD2 . PHE A 1 80  ? 190.630 249.127 327.400 1.00 40.51  ? 80  PHE A CD2 1 
ATOM   416  C CE1 . PHE A 1 80  ? 188.418 250.587 328.121 1.00 48.80  ? 80  PHE A CE1 1 
ATOM   417  C CE2 . PHE A 1 80  ? 190.114 249.014 328.672 1.00 44.03  ? 80  PHE A CE2 1 
ATOM   418  C CZ  . PHE A 1 80  ? 189.009 249.744 329.032 1.00 42.98  ? 80  PHE A CZ  1 
ATOM   419  N N   . PHE A 1 81  ? 193.427 251.779 325.215 1.00 50.06  ? 81  PHE A N   1 
ATOM   420  C CA  . PHE A 1 81  ? 194.581 252.161 326.016 1.00 42.31  ? 81  PHE A CA  1 
ATOM   421  C C   . PHE A 1 81  ? 195.364 253.330 325.436 1.00 48.31  ? 81  PHE A C   1 
ATOM   422  O O   . PHE A 1 81  ? 196.356 253.748 326.040 1.00 56.47  ? 81  PHE A O   1 
ATOM   423  C CB  . PHE A 1 81  ? 195.521 250.964 326.188 1.00 42.34  ? 81  PHE A CB  1 
ATOM   424  C CG  . PHE A 1 81  ? 195.022 249.937 327.158 1.00 35.97  ? 81  PHE A CG  1 
ATOM   425  C CD1 . PHE A 1 81  ? 195.136 250.141 328.519 1.00 38.22  ? 81  PHE A CD1 1 
ATOM   426  C CD2 . PHE A 1 81  ? 194.447 248.763 326.709 1.00 41.23  ? 81  PHE A CD2 1 
ATOM   427  C CE1 . PHE A 1 81  ? 194.682 249.200 329.409 1.00 45.94  ? 81  PHE A CE1 1 
ATOM   428  C CE2 . PHE A 1 81  ? 193.993 247.819 327.597 1.00 40.70  ? 81  PHE A CE2 1 
ATOM   429  C CZ  . PHE A 1 81  ? 194.110 248.037 328.948 1.00 46.27  ? 81  PHE A CZ  1 
ATOM   430  N N   . ALA A 1 82  ? 194.949 253.879 324.295 1.00 51.94  ? 82  ALA A N   1 
ATOM   431  C CA  . ALA A 1 82  ? 195.710 254.930 323.621 1.00 52.58  ? 82  ALA A CA  1 
ATOM   432  C C   . ALA A 1 82  ? 195.463 256.293 324.272 1.00 55.49  ? 82  ALA A C   1 
ATOM   433  O O   . ALA A 1 82  ? 195.069 257.264 323.629 1.00 57.38  ? 82  ALA A O   1 
ATOM   434  C CB  . ALA A 1 82  ? 195.360 254.962 322.140 1.00 56.11  ? 82  ALA A CB  1 
ATOM   435  N N   . ARG A 1 83  ? 195.725 256.356 325.576 1.00 53.20  ? 83  ARG A N   1 
ATOM   436  C CA  . ARG A 1 83  ? 195.563 257.600 326.324 1.00 48.28  ? 83  ARG A CA  1 
ATOM   437  C C   . ARG A 1 83  ? 196.471 257.563 327.540 1.00 52.79  ? 83  ARG A C   1 
ATOM   438  O O   . ARG A 1 83  ? 196.369 256.644 328.358 1.00 56.87  ? 83  ARG A O   1 
ATOM   439  C CB  . ARG A 1 83  ? 194.113 257.799 326.747 1.00 43.94  ? 83  ARG A CB  1 
ATOM   440  C CG  . ARG A 1 83  ? 193.252 258.433 325.684 1.00 48.88  ? 83  ARG A CG  1 
ATOM   441  C CD  . ARG A 1 83  ? 191.831 258.580 326.154 1.00 51.04  ? 83  ARG A CD  1 
ATOM   442  N NE  . ARG A 1 83  ? 191.029 259.352 325.215 1.00 55.78  ? 83  ARG A NE  1 
ATOM   443  C CZ  . ARG A 1 83  ? 190.635 258.914 324.028 1.00 59.39  ? 83  ARG A CZ  1 
ATOM   444  N NH1 . ARG A 1 83  ? 190.978 257.717 323.582 1.00 51.32  ? 83  ARG A NH1 1 
ATOM   445  N NH2 . ARG A 1 83  ? 189.879 259.698 323.266 1.00 65.04  ? 83  ARG A NH2 1 
ATOM   446  N N   . GLY A 1 84  ? 197.347 258.556 327.662 1.00 55.69  ? 84  GLY A N   1 
ATOM   447  C CA  . GLY A 1 84  ? 198.209 258.620 328.828 1.00 44.95  ? 84  GLY A CA  1 
ATOM   448  C C   . GLY A 1 84  ? 197.402 258.826 330.096 1.00 51.82  ? 84  GLY A C   1 
ATOM   449  O O   . GLY A 1 84  ? 196.379 259.514 330.100 1.00 59.29  ? 84  GLY A O   1 
ATOM   450  N N   . ALA A 1 85  ? 197.870 258.219 331.183 1.00 52.83  ? 85  ALA A N   1 
ATOM   451  C CA  . ALA A 1 85  ? 197.233 258.327 332.486 1.00 47.17  ? 85  ALA A CA  1 
ATOM   452  C C   . ALA A 1 85  ? 198.289 258.618 333.538 1.00 49.43  ? 85  ALA A C   1 
ATOM   453  O O   . ALA A 1 85  ? 199.364 258.015 333.528 1.00 59.60  ? 85  ALA A O   1 
ATOM   454  C CB  . ALA A 1 85  ? 196.486 257.044 332.849 1.00 45.37  ? 85  ALA A CB  1 
ATOM   455  N N   . CYS A 1 86  ? 197.981 259.540 334.444 1.00 45.27  ? 86  CYS A N   1 
ATOM   456  C CA  . CYS A 1 86  ? 198.913 259.852 335.518 1.00 46.39  ? 86  CYS A CA  1 
ATOM   457  C C   . CYS A 1 86  ? 199.193 258.603 336.339 1.00 53.84  ? 86  CYS A C   1 
ATOM   458  O O   . CYS A 1 86  ? 198.282 257.838 336.665 1.00 62.55  ? 86  CYS A O   1 
ATOM   459  C CB  . CYS A 1 86  ? 198.349 260.951 336.414 1.00 53.99  ? 86  CYS A CB  1 
ATOM   460  S SG  . CYS A 1 86  ? 199.465 261.459 337.736 1.00 73.61  ? 86  CYS A SG  1 
ATOM   461  N N   . VAL A 1 87  ? 200.465 258.393 336.671 1.00 50.51  ? 87  VAL A N   1 
ATOM   462  C CA  . VAL A 1 87  ? 200.888 257.225 337.432 1.00 48.95  ? 87  VAL A CA  1 
ATOM   463  C C   . VAL A 1 87  ? 201.635 257.588 338.704 1.00 55.55  ? 87  VAL A C   1 
ATOM   464  O O   . VAL A 1 87  ? 201.952 256.693 339.491 1.00 55.65  ? 87  VAL A O   1 
ATOM   465  C CB  . VAL A 1 87  ? 201.744 256.275 336.569 1.00 51.59  ? 87  VAL A CB  1 
ATOM   466  C CG1 . VAL A 1 87  ? 200.911 255.690 335.447 1.00 52.97  ? 87  VAL A CG1 1 
ATOM   467  C CG2 . VAL A 1 87  ? 202.952 257.000 336.009 1.00 55.09  ? 87  VAL A CG2 1 
ATOM   468  N N   . THR A 1 88  ? 201.928 258.866 338.936 1.00 57.84  ? 88  THR A N   1 
ATOM   469  C CA  . THR A 1 88  ? 202.635 259.266 340.147 1.00 58.40  ? 88  THR A CA  1 
ATOM   470  C C   . THR A 1 88  ? 202.716 260.786 340.195 1.00 56.16  ? 88  THR A C   1 
ATOM   471  O O   . THR A 1 88  ? 202.469 261.477 339.202 1.00 60.60  ? 88  THR A O   1 
ATOM   472  C CB  . THR A 1 88  ? 204.041 258.676 340.213 1.00 65.13  ? 88  THR A CB  1 
ATOM   473  O OG1 . THR A 1 88  ? 204.600 258.918 341.509 1.00 68.48  ? 88  THR A OG1 1 
ATOM   474  C CG2 . THR A 1 88  ? 204.930 259.314 339.160 1.00 62.83  ? 88  THR A CG2 1 
ATOM   475  N N   . ILE A 1 89  ? 203.071 261.295 341.373 1.00 52.89  ? 89  ILE A N   1 
ATOM   476  C CA  . ILE A 1 89  ? 203.352 262.709 341.591 1.00 52.80  ? 89  ILE A CA  1 
ATOM   477  C C   . ILE A 1 89  ? 204.602 262.786 342.455 1.00 53.84  ? 89  ILE A C   1 
ATOM   478  O O   . ILE A 1 89  ? 204.595 262.318 343.598 1.00 62.71  ? 89  ILE A O   1 
ATOM   479  C CB  . ILE A 1 89  ? 202.187 263.444 342.277 1.00 60.11  ? 89  ILE A CB  1 
ATOM   480  C CG1 . ILE A 1 89  ? 200.919 263.363 341.427 1.00 61.15  ? 89  ILE A CG1 1 
ATOM   481  C CG2 . ILE A 1 89  ? 202.559 264.893 342.531 1.00 58.70  ? 89  ILE A CG2 1 
ATOM   482  C CD1 . ILE A 1 89  ? 199.657 263.715 342.185 1.00 60.94  ? 89  ILE A CD1 1 
ATOM   483  N N   . MET A 1 90  ? 205.668 263.374 341.921 1.00 55.60  ? 90  MET A N   1 
ATOM   484  C CA  . MET A 1 90  ? 206.961 263.417 342.592 1.00 59.05  ? 90  MET A CA  1 
ATOM   485  C C   . MET A 1 90  ? 207.251 264.847 343.020 1.00 59.44  ? 90  MET A C   1 
ATOM   486  O O   . MET A 1 90  ? 207.266 265.753 342.184 1.00 62.13  ? 90  MET A O   1 
ATOM   487  C CB  . MET A 1 90  ? 208.063 262.903 341.668 1.00 51.43  ? 90  MET A CB  1 
ATOM   488  C CG  . MET A 1 90  ? 207.735 261.583 341.001 1.00 53.53  ? 90  MET A CG  1 
ATOM   489  S SD  . MET A 1 90  ? 209.045 261.019 339.910 1.00 62.52  ? 90  MET A SD  1 
ATOM   490  C CE  . MET A 1 90  ? 210.403 260.906 341.067 1.00 63.32  ? 90  MET A CE  1 
ATOM   491  N N   . THR A 1 91  ? 207.502 265.043 344.310 1.00 57.52  ? 91  THR A N   1 
ATOM   492  C CA  . THR A 1 91  ? 207.745 266.365 344.870 1.00 57.82  ? 91  THR A CA  1 
ATOM   493  C C   . THR A 1 91  ? 209.242 266.596 345.012 1.00 58.79  ? 91  THR A C   1 
ATOM   494  O O   . THR A 1 91  ? 209.939 265.802 345.652 1.00 64.58  ? 91  THR A O   1 
ATOM   495  C CB  . THR A 1 91  ? 207.063 266.516 346.230 1.00 61.59  ? 91  THR A CB  1 
ATOM   496  O OG1 . THR A 1 91  ? 205.641 266.487 346.061 1.00 62.50  ? 91  THR A OG1 1 
ATOM   497  C CG2 . THR A 1 91  ? 207.468 267.823 346.892 1.00 61.25  ? 91  THR A CG2 1 
ATOM   498  N N   . VAL A 1 92  ? 209.730 267.681 344.416 1.00 63.74  ? 92  VAL A N   1 
ATOM   499  C CA  . VAL A 1 92  ? 211.136 268.060 344.498 1.00 62.92  ? 92  VAL A CA  1 
ATOM   500  C C   . VAL A 1 92  ? 211.204 269.549 344.795 1.00 67.39  ? 92  VAL A C   1 
ATOM   501  O O   . VAL A 1 92  ? 210.558 270.351 344.116 1.00 77.11  ? 92  VAL A O   1 
ATOM   502  C CB  . VAL A 1 92  ? 211.896 267.731 343.198 1.00 59.34  ? 92  VAL A CB  1 
ATOM   503  C CG1 . VAL A 1 92  ? 211.754 266.259 342.864 1.00 63.56  ? 92  VAL A CG1 1 
ATOM   504  C CG2 . VAL A 1 92  ? 211.390 268.584 342.052 1.00 60.43  ? 92  VAL A CG2 1 
ATOM   505  N N   . ASP A 1 93  ? 211.980 269.925 345.805 1.00 79.02  ? 93  ASP A N   1 
ATOM   506  C CA  . ASP A 1 93  ? 212.078 271.316 346.216 1.00 78.53  ? 93  ASP A CA  1 
ATOM   507  C C   . ASP A 1 93  ? 213.505 271.816 346.042 1.00 75.22  ? 93  ASP A C   1 
ATOM   508  O O   . ASP A 1 93  ? 214.442 271.045 345.823 1.00 76.77  ? 93  ASP A O   1 
ATOM   509  C CB  . ASP A 1 93  ? 211.621 271.500 347.670 1.00 80.13  ? 93  ASP A CB  1 
ATOM   510  C CG  . ASP A 1 93  ? 212.572 270.875 348.671 1.00 82.30  ? 93  ASP A CG  1 
ATOM   511  O OD1 . ASP A 1 93  ? 213.580 270.270 348.253 1.00 85.75  ? 93  ASP A OD1 1 
ATOM   512  O OD2 . ASP A 1 93  ? 212.312 270.994 349.886 1.00 81.74  ? 93  ASP A OD2 1 
ATOM   513  N N   . ASN A 1 94  ? 213.652 273.132 346.146 1.00 78.23  ? 94  ASN A N   1 
ATOM   514  C CA  . ASN A 1 94  ? 214.939 273.811 346.021 1.00 78.52  ? 94  ASN A CA  1 
ATOM   515  C C   . ASN A 1 94  ? 215.082 274.749 347.211 1.00 80.30  ? 94  ASN A C   1 
ATOM   516  O O   . ASN A 1 94  ? 215.019 275.975 347.069 1.00 82.12  ? 94  ASN A O   1 
ATOM   517  C CB  . ASN A 1 94  ? 215.027 274.565 344.694 1.00 76.07  ? 94  ASN A CB  1 
ATOM   518  C CG  . ASN A 1 94  ? 216.407 275.111 344.425 1.00 76.83  ? 94  ASN A CG  1 
ATOM   519  O OD1 . ASN A 1 94  ? 216.658 276.302 344.595 1.00 80.03  ? 94  ASN A OD1 1 
ATOM   520  N ND2 . ASN A 1 94  ? 217.313 274.241 343.998 1.00 76.03  ? 94  ASN A ND2 1 
ATOM   521  N N   . PRO A 1 95  ? 215.273 274.197 348.409 1.00 86.59  ? 95  PRO A N   1 
ATOM   522  C CA  . PRO A 1 95  ? 215.233 275.025 349.618 1.00 90.21  ? 95  PRO A CA  1 
ATOM   523  C C   . PRO A 1 95  ? 216.266 276.135 349.574 1.00 91.57  ? 95  PRO A C   1 
ATOM   524  O O   . PRO A 1 95  ? 217.369 275.966 349.050 1.00 92.06  ? 95  PRO A O   1 
ATOM   525  C CB  . PRO A 1 95  ? 215.530 274.027 350.742 1.00 90.65  ? 95  PRO A CB  1 
ATOM   526  C CG  . PRO A 1 95  ? 216.238 272.902 350.071 1.00 91.01  ? 95  PRO A CG  1 
ATOM   527  C CD  . PRO A 1 95  ? 215.600 272.799 348.722 1.00 90.30  ? 95  PRO A CD  1 
ATOM   528  N N   . ALA A 1 96  ? 215.896 277.279 350.138 1.00 98.76  ? 96  ALA A N   1 
ATOM   529  C CA  . ALA A 1 96  ? 216.788 278.425 350.138 1.00 99.04  ? 96  ALA A CA  1 
ATOM   530  C C   . ALA A 1 96  ? 218.091 278.079 350.843 1.00 100.58 ? 96  ALA A C   1 
ATOM   531  O O   . ALA A 1 96  ? 218.102 277.375 351.856 1.00 99.30  ? 96  ALA A O   1 
ATOM   532  C CB  . ALA A 1 96  ? 216.120 279.618 350.820 1.00 100.05 ? 96  ALA A CB  1 
ATOM   533  N N   . SER A 1 97  ? 219.201 278.576 350.295 1.00 103.76 ? 97  SER A N   1 
ATOM   534  C CA  . SER A 1 97  ? 220.494 278.349 350.927 1.00 103.17 ? 97  SER A CA  1 
ATOM   535  C C   . SER A 1 97  ? 220.550 278.947 352.325 1.00 106.84 ? 97  SER A C   1 
ATOM   536  O O   . SER A 1 97  ? 221.410 278.557 353.122 1.00 105.46 ? 97  SER A O   1 
ATOM   537  C CB  . SER A 1 97  ? 221.610 278.930 350.060 1.00 101.34 ? 97  SER A CB  1 
ATOM   538  O OG  . SER A 1 97  ? 221.362 280.290 349.756 1.00 101.06 ? 97  SER A OG  1 
ATOM   539  N N   . THR A 1 98  ? 219.653 279.885 352.640 1.00 113.64 ? 98  THR A N   1 
ATOM   540  C CA  . THR A 1 98  ? 219.592 280.425 353.993 1.00 112.11 ? 98  THR A CA  1 
ATOM   541  C C   . THR A 1 98  ? 219.271 279.333 355.004 1.00 110.36 ? 98  THR A C   1 
ATOM   542  O O   . THR A 1 98  ? 219.878 279.274 356.080 1.00 109.10 ? 98  THR A O   1 
ATOM   543  C CB  . THR A 1 98  ? 218.549 281.541 354.063 1.00 110.91 ? 98  THR A CB  1 
ATOM   544  O OG1 . THR A 1 98  ? 218.875 282.564 353.115 1.00 110.57 ? 98  THR A OG1 1 
ATOM   545  C CG2 . THR A 1 98  ? 218.499 282.143 355.460 1.00 110.01 ? 98  THR A CG2 1 
ATOM   546  N N   . THR A 1 99  ? 218.322 278.459 354.679 1.00 112.53 ? 99  THR A N   1 
ATOM   547  C CA  . THR A 1 99  ? 217.963 277.348 355.550 1.00 114.88 ? 99  THR A CA  1 
ATOM   548  C C   . THR A 1 99  ? 218.874 276.160 355.261 1.00 113.82 ? 99  THR A C   1 
ATOM   549  O O   . THR A 1 99  ? 219.070 275.785 354.101 1.00 111.82 ? 99  THR A O   1 
ATOM   550  C CB  . THR A 1 99  ? 216.494 276.953 355.371 1.00 115.02 ? 99  THR A CB  1 
ATOM   551  O OG1 . THR A 1 99  ? 216.217 275.775 356.139 1.00 114.57 ? 99  THR A OG1 1 
ATOM   552  C CG2 . THR A 1 99  ? 216.157 276.691 353.905 1.00 112.52 ? 99  THR A CG2 1 
ATOM   553  N N   . ASN A 1 100 ? 219.432 275.577 356.323 1.00 115.97 ? 100 ASN A N   1 
ATOM   554  C CA  . ASN A 1 100 ? 220.403 274.499 356.179 1.00 116.47 ? 100 ASN A CA  1 
ATOM   555  C C   . ASN A 1 100 ? 219.782 273.192 355.706 1.00 116.55 ? 100 ASN A C   1 
ATOM   556  O O   . ASN A 1 100 ? 220.526 272.266 355.365 1.00 114.02 ? 100 ASN A O   1 
ATOM   557  C CB  . ASN A 1 100 ? 221.121 274.268 357.510 1.00 114.28 ? 100 ASN A CB  1 
ATOM   558  C CG  . ASN A 1 100 ? 220.164 273.939 358.638 1.00 114.35 ? 100 ASN A CG  1 
ATOM   559  O OD1 . ASN A 1 100 ? 219.020 274.395 358.650 1.00 114.49 ? 100 ASN A OD1 1 
ATOM   560  N ND2 . ASN A 1 100 ? 220.627 273.143 359.594 1.00 113.47 ? 100 ASN A ND2 1 
ATOM   561  N N   . LYS A 1 101 ? 218.455 273.087 355.679 1.00 110.46 ? 101 LYS A N   1 
ATOM   562  C CA  . LYS A 1 101 ? 217.819 271.839 355.280 1.00 109.21 ? 101 LYS A CA  1 
ATOM   563  C C   . LYS A 1 101 ? 218.219 271.471 353.857 1.00 107.97 ? 101 LYS A C   1 
ATOM   564  O O   . LYS A 1 101 ? 218.191 272.310 352.952 1.00 107.04 ? 101 LYS A O   1 
ATOM   565  C CB  . LYS A 1 101 ? 216.300 271.963 355.396 1.00 109.18 ? 101 LYS A CB  1 
ATOM   566  C CG  . LYS A 1 101 ? 215.822 272.328 356.796 1.00 107.78 ? 101 LYS A CG  1 
ATOM   567  C CD  . LYS A 1 101 ? 214.303 272.358 356.895 1.00 107.72 ? 101 LYS A CD  1 
ATOM   568  C CE  . LYS A 1 101 ? 213.697 270.962 356.837 1.00 108.11 ? 101 LYS A CE  1 
ATOM   569  N NZ  . LYS A 1 101 ? 214.167 270.093 357.951 1.00 107.88 ? 101 LYS A NZ  1 
ATOM   570  N N   . ASP A 1 102 ? 218.590 270.209 353.664 1.00 90.17  ? 102 ASP A N   1 
ATOM   571  C CA  . ASP A 1 102 ? 219.097 269.753 352.380 1.00 90.03  ? 102 ASP A CA  1 
ATOM   572  C C   . ASP A 1 102 ? 217.979 269.709 351.341 1.00 89.26  ? 102 ASP A C   1 
ATOM   573  O O   . ASP A 1 102 ? 216.789 269.689 351.665 1.00 86.57  ? 102 ASP A O   1 
ATOM   574  C CB  . ASP A 1 102 ? 219.737 268.372 352.526 1.00 92.59  ? 102 ASP A CB  1 
ATOM   575  C CG  . ASP A 1 102 ? 220.347 267.868 351.232 1.00 93.63  ? 102 ASP A CG  1 
ATOM   576  O OD1 . ASP A 1 102 ? 221.321 268.484 350.752 1.00 92.33  ? 102 ASP A OD1 1 
ATOM   577  O OD2 . ASP A 1 102 ? 219.852 266.854 350.697 1.00 91.34  ? 102 ASP A OD2 1 
ATOM   578  N N   . LYS A 1 103 ? 218.381 269.700 350.073 1.00 79.61  ? 103 LYS A N   1 
ATOM   579  C CA  . LYS A 1 103 ? 217.423 269.614 348.982 1.00 76.55  ? 103 LYS A CA  1 
ATOM   580  C C   . LYS A 1 103 ? 216.693 268.277 349.013 1.00 73.09  ? 103 LYS A C   1 
ATOM   581  O O   . LYS A 1 103 ? 217.200 267.276 349.526 1.00 73.03  ? 103 LYS A O   1 
ATOM   582  C CB  . LYS A 1 103 ? 218.125 269.784 347.635 1.00 76.74  ? 103 LYS A CB  1 
ATOM   583  C CG  . LYS A 1 103 ? 218.772 271.147 347.428 1.00 79.80  ? 103 LYS A CG  1 
ATOM   584  C CD  . LYS A 1 103 ? 219.403 271.280 346.049 1.00 77.30  ? 103 LYS A CD  1 
ATOM   585  C CE  . LYS A 1 103 ? 218.398 271.075 344.924 1.00 76.07  ? 103 LYS A CE  1 
ATOM   586  N NZ  . LYS A 1 103 ? 218.999 271.327 343.588 1.00 73.95  ? 103 LYS A NZ  1 
ATOM   587  N N   . LEU A 1 104 ? 215.487 268.271 348.455 1.00 73.54  ? 104 LEU A N   1 
ATOM   588  C CA  . LEU A 1 104 ? 214.628 267.091 348.416 1.00 75.67  ? 104 LEU A CA  1 
ATOM   589  C C   . LEU A 1 104 ? 214.485 266.648 346.965 1.00 74.70  ? 104 LEU A C   1 
ATOM   590  O O   . LEU A 1 104 ? 213.683 267.208 346.213 1.00 78.65  ? 104 LEU A O   1 
ATOM   591  C CB  . LEU A 1 104 ? 213.266 267.394 349.033 1.00 75.23  ? 104 LEU A CB  1 
ATOM   592  C CG  . LEU A 1 104 ? 212.244 266.257 349.056 1.00 76.36  ? 104 LEU A CG  1 
ATOM   593  C CD1 . LEU A 1 104 ? 212.601 265.229 350.115 1.00 77.36  ? 104 LEU A CD1 1 
ATOM   594  C CD2 . LEU A 1 104 ? 210.848 266.811 349.285 1.00 73.74  ? 104 LEU A CD2 1 
ATOM   595  N N   . PHE A 1 105 ? 215.262 265.646 346.573 1.00 69.10  ? 105 PHE A N   1 
ATOM   596  C CA  . PHE A 1 105 ? 215.099 264.999 345.281 1.00 68.06  ? 105 PHE A CA  1 
ATOM   597  C C   . PHE A 1 105 ? 214.219 263.768 345.453 1.00 70.87  ? 105 PHE A C   1 
ATOM   598  O O   . PHE A 1 105 ? 214.260 263.095 346.485 1.00 69.82  ? 105 PHE A O   1 
ATOM   599  C CB  . PHE A 1 105 ? 216.450 264.609 344.680 1.00 65.29  ? 105 PHE A CB  1 
ATOM   600  C CG  . PHE A 1 105 ? 217.133 263.484 345.399 1.00 68.04  ? 105 PHE A CG  1 
ATOM   601  C CD1 . PHE A 1 105 ? 217.861 263.721 346.549 1.00 68.03  ? 105 PHE A CD1 1 
ATOM   602  C CD2 . PHE A 1 105 ? 217.053 262.191 344.917 1.00 65.89  ? 105 PHE A CD2 1 
ATOM   603  C CE1 . PHE A 1 105 ? 218.488 262.688 347.209 1.00 71.04  ? 105 PHE A CE1 1 
ATOM   604  C CE2 . PHE A 1 105 ? 217.680 261.154 345.573 1.00 67.02  ? 105 PHE A CE2 1 
ATOM   605  C CZ  . PHE A 1 105 ? 218.398 261.403 346.719 1.00 69.99  ? 105 PHE A CZ  1 
ATOM   606  N N   . ALA A 1 106 ? 213.415 263.481 344.435 1.00 65.15  ? 106 ALA A N   1 
ATOM   607  C CA  . ALA A 1 106 ? 212.372 262.470 344.537 1.00 61.09  ? 106 ALA A CA  1 
ATOM   608  C C   . ALA A 1 106 ? 212.806 261.188 343.844 1.00 58.00  ? 106 ALA A C   1 
ATOM   609  O O   . ALA A 1 106 ? 213.150 261.204 342.660 1.00 61.58  ? 106 ALA A O   1 
ATOM   610  C CB  . ALA A 1 106 ? 211.066 262.978 343.926 1.00 64.87  ? 106 ALA A CB  1 
ATOM   611  N N   . VAL A 1 107 ? 212.775 260.083 344.580 1.00 52.57  ? 107 VAL A N   1 
ATOM   612  C CA  . VAL A 1 107 ? 213.045 258.757 344.039 1.00 56.53  ? 107 VAL A CA  1 
ATOM   613  C C   . VAL A 1 107 ? 211.733 257.989 344.055 1.00 53.48  ? 107 VAL A C   1 
ATOM   614  O O   . VAL A 1 107 ? 211.201 257.675 345.127 1.00 55.09  ? 107 VAL A O   1 
ATOM   615  C CB  . VAL A 1 107 ? 214.128 258.023 344.839 1.00 58.36  ? 107 VAL A CB  1 
ATOM   616  C CG1 . VAL A 1 107 ? 214.065 256.530 344.570 1.00 57.72  ? 107 VAL A CG1 1 
ATOM   617  C CG2 . VAL A 1 107 ? 215.501 258.568 344.489 1.00 59.50  ? 107 VAL A CG2 1 
ATOM   618  N N   . TRP A 1 108 ? 211.210 257.678 342.872 1.00 50.54  ? 108 TRP A N   1 
ATOM   619  C CA  . TRP A 1 108 ? 209.937 256.984 342.729 1.00 54.30  ? 108 TRP A CA  1 
ATOM   620  C C   . TRP A 1 108 ? 210.182 255.655 342.034 1.00 57.07  ? 108 TRP A C   1 
ATOM   621  O O   . TRP A 1 108 ? 210.708 255.624 340.918 1.00 62.16  ? 108 TRP A O   1 
ATOM   622  C CB  . TRP A 1 108 ? 208.944 257.835 341.936 1.00 52.49  ? 108 TRP A CB  1 
ATOM   623  C CG  . TRP A 1 108 ? 207.760 257.083 341.415 1.00 53.01  ? 108 TRP A CG  1 
ATOM   624  C CD1 . TRP A 1 108 ? 206.738 256.556 342.144 1.00 54.15  ? 108 TRP A CD1 1 
ATOM   625  C CD2 . TRP A 1 108 ? 207.468 256.788 340.044 1.00 53.47  ? 108 TRP A CD2 1 
ATOM   626  N NE1 . TRP A 1 108 ? 205.830 255.947 341.315 1.00 59.20  ? 108 TRP A NE1 1 
ATOM   627  C CE2 . TRP A 1 108 ? 206.256 256.076 340.020 1.00 59.52  ? 108 TRP A CE2 1 
ATOM   628  C CE3 . TRP A 1 108 ? 208.115 257.056 338.835 1.00 54.45  ? 108 TRP A CE3 1 
ATOM   629  C CZ2 . TRP A 1 108 ? 205.679 255.627 338.836 1.00 56.90  ? 108 TRP A CZ2 1 
ATOM   630  C CZ3 . TRP A 1 108 ? 207.540 256.609 337.661 1.00 53.35  ? 108 TRP A CZ3 1 
ATOM   631  C CH2 . TRP A 1 108 ? 206.335 255.904 337.670 1.00 48.14  ? 108 TRP A CH2 1 
ATOM   632  N N   . LYS A 1 109 ? 209.818 254.561 342.694 1.00 60.21  ? 109 LYS A N   1 
ATOM   633  C CA  . LYS A 1 109 ? 209.945 253.252 342.071 1.00 57.80  ? 109 LYS A CA  1 
ATOM   634  C C   . LYS A 1 109 ? 208.931 253.129 340.943 1.00 54.12  ? 109 LYS A C   1 
ATOM   635  O O   . LYS A 1 109 ? 207.746 253.420 341.125 1.00 59.57  ? 109 LYS A O   1 
ATOM   636  C CB  . LYS A 1 109 ? 209.735 252.144 343.098 1.00 53.57  ? 109 LYS A CB  1 
ATOM   637  C CG  . LYS A 1 109 ? 210.008 250.756 342.551 1.00 53.11  ? 109 LYS A CG  1 
ATOM   638  C CD  . LYS A 1 109 ? 209.674 249.675 343.558 1.00 57.49  ? 109 LYS A CD  1 
ATOM   639  C CE  . LYS A 1 109 ? 210.040 248.298 343.027 1.00 67.39  ? 109 LYS A CE  1 
ATOM   640  N NZ  . LYS A 1 109 ? 209.461 248.032 341.679 1.00 64.39  ? 109 LYS A NZ  1 
ATOM   641  N N   . ILE A 1 110 ? 209.396 252.693 339.774 1.00 44.08  ? 110 ILE A N   1 
ATOM   642  C CA  . ILE A 1 110 ? 208.527 252.632 338.608 1.00 49.48  ? 110 ILE A CA  1 
ATOM   643  C C   . ILE A 1 110 ? 207.448 251.586 338.835 1.00 53.64  ? 110 ILE A C   1 
ATOM   644  O O   . ILE A 1 110 ? 207.739 250.430 339.166 1.00 53.89  ? 110 ILE A O   1 
ATOM   645  C CB  . ILE A 1 110 ? 209.343 252.326 337.345 1.00 56.58  ? 110 ILE A CB  1 
ATOM   646  C CG1 . ILE A 1 110 ? 210.242 253.515 337.014 1.00 55.80  ? 110 ILE A CG1 1 
ATOM   647  C CG2 . ILE A 1 110 ? 208.417 252.003 336.183 1.00 61.03  ? 110 ILE A CG2 1 
ATOM   648  C CD1 . ILE A 1 110 ? 211.169 253.278 335.859 1.00 53.32  ? 110 ILE A CD1 1 
ATOM   649  N N   . THR A 1 111 ? 206.194 251.990 338.658 1.00 53.67  ? 111 THR A N   1 
ATOM   650  C CA  . THR A 1 111 ? 205.058 251.091 338.782 1.00 52.32  ? 111 THR A CA  1 
ATOM   651  C C   . THR A 1 111 ? 203.799 251.850 338.400 1.00 54.72  ? 111 THR A C   1 
ATOM   652  O O   . THR A 1 111 ? 203.734 253.074 338.538 1.00 57.40  ? 111 THR A O   1 
ATOM   653  C CB  . THR A 1 111 ? 204.924 250.534 340.204 1.00 53.18  ? 111 THR A CB  1 
ATOM   654  O OG1 . THR A 1 111 ? 203.779 249.677 340.275 1.00 61.44  ? 111 THR A OG1 1 
ATOM   655  C CG2 . THR A 1 111 ? 204.770 251.662 341.212 1.00 47.30  ? 111 THR A CG2 1 
ATOM   656  N N   . TYR A 1 112 ? 202.803 251.110 337.922 1.00 56.35  ? 112 TYR A N   1 
ATOM   657  C CA  . TYR A 1 112 ? 201.500 251.667 337.595 1.00 53.51  ? 112 TYR A CA  1 
ATOM   658  C C   . TYR A 1 112 ? 200.466 251.381 338.673 1.00 54.81  ? 112 TYR A C   1 
ATOM   659  O O   . TYR A 1 112 ? 199.271 251.576 338.438 1.00 60.86  ? 112 TYR A O   1 
ATOM   660  C CB  . TYR A 1 112 ? 201.014 251.125 336.251 1.00 50.09  ? 112 TYR A CB  1 
ATOM   661  C CG  . TYR A 1 112 ? 200.775 249.636 336.239 1.00 51.89  ? 112 TYR A CG  1 
ATOM   662  C CD1 . TYR A 1 112 ? 201.808 248.751 335.976 1.00 51.57  ? 112 TYR A CD1 1 
ATOM   663  C CD2 . TYR A 1 112 ? 199.515 249.114 336.484 1.00 53.11  ? 112 TYR A CD2 1 
ATOM   664  C CE1 . TYR A 1 112 ? 201.594 247.389 335.961 1.00 53.43  ? 112 TYR A CE1 1 
ATOM   665  C CE2 . TYR A 1 112 ? 199.291 247.754 336.470 1.00 57.26  ? 112 TYR A CE2 1 
ATOM   666  C CZ  . TYR A 1 112 ? 200.334 246.897 336.209 1.00 57.26  ? 112 TYR A CZ  1 
ATOM   667  O OH  . TYR A 1 112 ? 200.117 245.541 336.194 1.00 61.74  ? 112 TYR A OH  1 
ATOM   668  N N   . LYS A 1 113 ? 200.899 250.921 339.845 1.00 56.24  ? 113 LYS A N   1 
ATOM   669  C CA  . LYS A 1 113 ? 200.002 250.566 340.933 1.00 54.07  ? 113 LYS A CA  1 
ATOM   670  C C   . LYS A 1 113 ? 199.903 251.655 341.990 1.00 57.25  ? 113 LYS A C   1 
ATOM   671  O O   . LYS A 1 113 ? 199.344 251.412 343.063 1.00 60.10  ? 113 LYS A O   1 
ATOM   672  C CB  . LYS A 1 113 ? 200.454 249.252 341.570 1.00 52.49  ? 113 LYS A CB  1 
ATOM   673  C CG  . LYS A 1 113 ? 200.544 248.111 340.573 1.00 54.77  ? 113 LYS A CG  1 
ATOM   674  C CD  . LYS A 1 113 ? 200.624 246.759 341.250 1.00 58.68  ? 113 LYS A CD  1 
ATOM   675  C CE  . LYS A 1 113 ? 200.550 245.639 340.225 1.00 58.14  ? 113 LYS A CE  1 
ATOM   676  N NZ  . LYS A 1 113 ? 200.489 244.293 340.854 1.00 59.25  ? 113 LYS A NZ  1 
ATOM   677  N N   . ASP A 1 114 ? 200.442 252.845 341.719 1.00 66.08  ? 114 ASP A N   1 
ATOM   678  C CA  . ASP A 1 114 ? 200.237 253.972 342.621 1.00 67.23  ? 114 ASP A CA  1 
ATOM   679  C C   . ASP A 1 114 ? 198.835 254.547 342.475 1.00 66.48  ? 114 ASP A C   1 
ATOM   680  O O   . ASP A 1 114 ? 198.221 254.954 343.467 1.00 70.21  ? 114 ASP A O   1 
ATOM   681  C CB  . ASP A 1 114 ? 201.279 255.056 342.353 1.00 70.76  ? 114 ASP A CB  1 
ATOM   682  C CG  . ASP A 1 114 ? 202.695 254.546 342.481 1.00 77.48  ? 114 ASP A CG  1 
ATOM   683  O OD1 . ASP A 1 114 ? 202.945 253.692 343.357 1.00 81.87  ? 114 ASP A OD1 1 
ATOM   684  O OD2 . ASP A 1 114 ? 203.560 254.997 341.702 1.00 73.37  ? 114 ASP A OD2 1 
ATOM   685  N N   . THR A 1 115 ? 198.323 254.593 341.251 1.00 56.64  ? 115 THR A N   1 
ATOM   686  C CA  . THR A 1 115 ? 196.986 255.079 340.966 1.00 62.48  ? 115 THR A CA  1 
ATOM   687  C C   . THR A 1 115 ? 196.022 253.899 340.878 1.00 58.21  ? 115 THR A C   1 
ATOM   688  O O   . THR A 1 115 ? 196.370 252.757 341.190 1.00 63.05  ? 115 THR A O   1 
ATOM   689  C CB  . THR A 1 115 ? 196.991 255.901 339.677 1.00 68.48  ? 115 THR A CB  1 
ATOM   690  O OG1 . THR A 1 115 ? 197.400 255.075 338.581 1.00 68.90  ? 115 THR A OG1 1 
ATOM   691  C CG2 . THR A 1 115 ? 197.940 257.081 339.806 1.00 62.06  ? 115 THR A CG2 1 
ATOM   692  N N   . VAL A 1 116 ? 194.788 254.174 340.452 1.00 46.24  ? 116 VAL A N   1 
ATOM   693  C CA  . VAL A 1 116 ? 193.757 253.158 340.317 1.00 46.89  ? 116 VAL A CA  1 
ATOM   694  C C   . VAL A 1 116 ? 193.273 253.027 338.880 1.00 52.95  ? 116 VAL A C   1 
ATOM   695  O O   . VAL A 1 116 ? 193.104 251.911 338.378 1.00 65.32  ? 116 VAL A O   1 
ATOM   696  C CB  . VAL A 1 116 ? 192.569 253.445 341.259 1.00 42.19  ? 116 VAL A CB  1 
ATOM   697  C CG1 . VAL A 1 116 ? 193.035 253.487 342.700 1.00 52.49  ? 116 VAL A CG1 1 
ATOM   698  C CG2 . VAL A 1 116 ? 191.882 254.746 340.880 1.00 40.15  ? 116 VAL A CG2 1 
ATOM   699  N N   . GLN A 1 117 ? 193.049 254.150 338.196 1.00 53.09  ? 117 GLN A N   1 
ATOM   700  C CA  . GLN A 1 117 ? 192.368 254.103 336.906 1.00 52.24  ? 117 GLN A CA  1 
ATOM   701  C C   . GLN A 1 117 ? 193.166 253.306 335.882 1.00 49.96  ? 117 GLN A C   1 
ATOM   702  O O   . GLN A 1 117 ? 192.632 252.396 335.237 1.00 52.66  ? 117 GLN A O   1 
ATOM   703  C CB  . GLN A 1 117 ? 192.107 255.520 336.406 1.00 55.65  ? 117 GLN A CB  1 
ATOM   704  C CG  . GLN A 1 117 ? 191.190 256.325 337.305 1.00 56.35  ? 117 GLN A CG  1 
ATOM   705  C CD  . GLN A 1 117 ? 190.865 257.683 336.730 1.00 56.07  ? 117 GLN A CD  1 
ATOM   706  O OE1 . GLN A 1 117 ? 191.553 258.172 335.836 1.00 57.65  ? 117 GLN A OE1 1 
ATOM   707  N NE2 . GLN A 1 117 ? 189.805 258.301 337.237 1.00 53.49  ? 117 GLN A NE2 1 
ATOM   708  N N   . LEU A 1 118 ? 194.447 253.634 335.710 1.00 51.33  ? 118 LEU A N   1 
ATOM   709  C CA  . LEU A 1 118 ? 195.275 252.847 334.803 1.00 55.93  ? 118 LEU A CA  1 
ATOM   710  C C   . LEU A 1 118 ? 195.425 251.419 335.308 1.00 57.85  ? 118 LEU A C   1 
ATOM   711  O O   . LEU A 1 118 ? 195.376 250.464 334.523 1.00 57.41  ? 118 LEU A O   1 
ATOM   712  C CB  . LEU A 1 118 ? 196.646 253.495 334.631 1.00 55.16  ? 118 LEU A CB  1 
ATOM   713  C CG  . LEU A 1 118 ? 197.658 252.658 333.845 1.00 50.60  ? 118 LEU A CG  1 
ATOM   714  C CD1 . LEU A 1 118 ? 197.120 252.298 332.472 1.00 43.23  ? 118 LEU A CD1 1 
ATOM   715  C CD2 . LEU A 1 118 ? 198.974 253.396 333.722 1.00 62.52  ? 118 LEU A CD2 1 
ATOM   716  N N   . ARG A 1 119 ? 195.612 251.255 336.617 1.00 51.80  ? 119 ARG A N   1 
ATOM   717  C CA  . ARG A 1 119 ? 195.714 249.915 337.177 1.00 50.71  ? 119 ARG A CA  1 
ATOM   718  C C   . ARG A 1 119 ? 194.451 249.116 336.898 1.00 49.98  ? 119 ARG A C   1 
ATOM   719  O O   . ARG A 1 119 ? 194.522 247.947 336.508 1.00 54.51  ? 119 ARG A O   1 
ATOM   720  C CB  . ARG A 1 119 ? 195.979 249.995 338.679 1.00 55.17  ? 119 ARG A CB  1 
ATOM   721  C CG  . ARG A 1 119 ? 196.187 248.650 339.347 1.00 53.76  ? 119 ARG A CG  1 
ATOM   722  C CD  . ARG A 1 119 ? 196.350 248.797 340.846 1.00 53.92  ? 119 ARG A CD  1 
ATOM   723  N NE  . ARG A 1 119 ? 196.549 247.510 341.501 1.00 56.47  ? 119 ARG A NE  1 
ATOM   724  C CZ  . ARG A 1 119 ? 196.729 247.352 342.805 1.00 57.40  ? 119 ARG A CZ  1 
ATOM   725  N NH1 . ARG A 1 119 ? 196.736 248.383 343.633 1.00 59.84  ? 119 ARG A NH1 1 
ATOM   726  N NH2 . ARG A 1 119 ? 196.902 246.127 343.292 1.00 54.64  ? 119 ARG A NH2 1 
ATOM   727  N N   . ARG A 1 120 ? 193.283 249.733 337.087 1.00 52.40  ? 120 ARG A N   1 
ATOM   728  C CA  . ARG A 1 120 ? 192.032 249.019 336.865 1.00 48.02  ? 120 ARG A CA  1 
ATOM   729  C C   . ARG A 1 120 ? 191.832 248.694 335.392 1.00 47.98  ? 120 ARG A C   1 
ATOM   730  O O   . ARG A 1 120 ? 191.323 247.621 335.053 1.00 52.73  ? 120 ARG A O   1 
ATOM   731  C CB  . ARG A 1 120 ? 190.859 249.839 337.394 1.00 42.47  ? 120 ARG A CB  1 
ATOM   732  C CG  . ARG A 1 120 ? 189.554 249.073 337.430 1.00 48.24  ? 120 ARG A CG  1 
ATOM   733  C CD  . ARG A 1 120 ? 188.452 249.903 338.047 1.00 50.30  ? 120 ARG A CD  1 
ATOM   734  N NE  . ARG A 1 120 ? 187.242 249.126 338.284 1.00 52.74  ? 120 ARG A NE  1 
ATOM   735  C CZ  . ARG A 1 120 ? 186.329 248.855 337.361 1.00 49.32  ? 120 ARG A CZ  1 
ATOM   736  N NH1 . ARG A 1 120 ? 186.467 249.262 336.110 1.00 50.30  ? 120 ARG A NH1 1 
ATOM   737  N NH2 . ARG A 1 120 ? 185.252 248.155 337.701 1.00 49.06  ? 120 ARG A NH2 1 
ATOM   738  N N   . LYS A 1 121 ? 192.214 249.609 334.500 1.00 38.78  ? 121 LYS A N   1 
ATOM   739  C CA  . LYS A 1 121 ? 192.101 249.321 333.075 1.00 35.57  ? 121 LYS A CA  1 
ATOM   740  C C   . LYS A 1 121 ? 193.009 248.167 332.674 1.00 37.29  ? 121 LYS A C   1 
ATOM   741  O O   . LYS A 1 121 ? 192.626 247.324 331.857 1.00 32.29  ? 121 LYS A O   1 
ATOM   742  C CB  . LYS A 1 121 ? 192.430 250.565 332.254 1.00 41.79  ? 121 LYS A CB  1 
ATOM   743  C CG  . LYS A 1 121 ? 191.336 251.618 332.250 1.00 41.27  ? 121 LYS A CG  1 
ATOM   744  C CD  . LYS A 1 121 ? 191.686 252.787 331.345 1.00 39.78  ? 121 LYS A CD  1 
ATOM   745  C CE  . LYS A 1 121 ? 191.628 252.403 329.876 1.00 38.25  ? 121 LYS A CE  1 
ATOM   746  N NZ  . LYS A 1 121 ? 192.013 253.532 328.990 1.00 50.78  ? 121 LYS A NZ  1 
ATOM   747  N N   . LEU A 1 122 ? 194.221 248.116 333.231 1.00 51.39  ? 122 LEU A N   1 
ATOM   748  C CA  . LEU A 1 122 ? 195.148 247.048 332.868 1.00 48.63  ? 122 LEU A CA  1 
ATOM   749  C C   . LEU A 1 122 ? 194.729 245.715 333.474 1.00 50.13  ? 122 LEU A C   1 
ATOM   750  O O   . LEU A 1 122 ? 194.888 244.666 332.842 1.00 53.42  ? 122 LEU A O   1 
ATOM   751  C CB  . LEU A 1 122 ? 196.567 247.408 333.304 1.00 42.64  ? 122 LEU A CB  1 
ATOM   752  C CG  . LEU A 1 122 ? 197.386 248.241 332.317 1.00 50.04  ? 122 LEU A CG  1 
ATOM   753  C CD1 . LEU A 1 122 ? 198.703 248.653 332.939 1.00 55.45  ? 122 LEU A CD1 1 
ATOM   754  C CD2 . LEU A 1 122 ? 197.631 247.473 331.032 1.00 44.18  ? 122 LEU A CD2 1 
ATOM   755  N N   . GLU A 1 123 ? 194.193 245.730 334.690 1.00 50.85  ? 123 GLU A N   1 
ATOM   756  C CA  . GLU A 1 123 ? 193.859 244.495 335.384 1.00 47.35  ? 123 GLU A CA  1 
ATOM   757  C C   . GLU A 1 123 ? 192.576 243.855 334.873 1.00 49.25  ? 123 GLU A C   1 
ATOM   758  O O   . GLU A 1 123 ? 192.071 242.925 335.509 1.00 49.47  ? 123 GLU A O   1 
ATOM   759  C CB  . GLU A 1 123 ? 193.760 244.750 336.887 1.00 49.40  ? 123 GLU A CB  1 
ATOM   760  C CG  . GLU A 1 123 ? 195.107 245.017 337.535 1.00 55.84  ? 123 GLU A CG  1 
ATOM   761  C CD  . GLU A 1 123 ? 195.010 245.190 339.035 1.00 61.46  ? 123 GLU A CD  1 
ATOM   762  O OE1 . GLU A 1 123 ? 193.913 244.971 339.587 1.00 58.86  ? 123 GLU A OE1 1 
ATOM   763  O OE2 . GLU A 1 123 ? 196.031 245.545 339.662 1.00 60.99  ? 123 GLU A OE2 1 
ATOM   764  N N   . PHE A 1 124 ? 192.035 244.332 333.752 1.00 49.05  ? 124 PHE A N   1 
ATOM   765  C CA  . PHE A 1 124 ? 191.074 243.528 333.008 1.00 45.57  ? 124 PHE A CA  1 
ATOM   766  C C   . PHE A 1 124 ? 191.725 242.245 332.518 1.00 51.91  ? 124 PHE A C   1 
ATOM   767  O O   . PHE A 1 124 ? 191.113 241.172 332.552 1.00 54.54  ? 124 PHE A O   1 
ATOM   768  C CB  . PHE A 1 124 ? 190.529 244.315 331.817 1.00 42.22  ? 124 PHE A CB  1 
ATOM   769  C CG  . PHE A 1 124 ? 189.334 245.162 332.133 1.00 44.67  ? 124 PHE A CG  1 
ATOM   770  C CD1 . PHE A 1 124 ? 189.473 246.356 332.813 1.00 57.21  ? 124 PHE A CD1 1 
ATOM   771  C CD2 . PHE A 1 124 ? 188.075 244.778 331.720 1.00 42.44  ? 124 PHE A CD2 1 
ATOM   772  C CE1 . PHE A 1 124 ? 188.375 247.140 333.090 1.00 48.05  ? 124 PHE A CE1 1 
ATOM   773  C CE2 . PHE A 1 124 ? 186.976 245.559 331.993 1.00 50.71  ? 124 PHE A CE2 1 
ATOM   774  C CZ  . PHE A 1 124 ? 187.127 246.742 332.677 1.00 51.56  ? 124 PHE A CZ  1 
ATOM   775  N N   . PHE A 1 125 ? 192.971 242.341 332.065 1.00 37.21  ? 125 PHE A N   1 
ATOM   776  C CA  . PHE A 1 125 ? 193.691 241.249 331.436 1.00 33.07  ? 125 PHE A CA  1 
ATOM   777  C C   . PHE A 1 125 ? 194.829 240.779 332.330 1.00 33.02  ? 125 PHE A C   1 
ATOM   778  O O   . PHE A 1 125 ? 195.299 241.503 333.210 1.00 41.34  ? 125 PHE A O   1 
ATOM   779  C CB  . PHE A 1 125 ? 194.233 241.686 330.075 1.00 35.80  ? 125 PHE A CB  1 
ATOM   780  C CG  . PHE A 1 125 ? 193.185 242.263 329.173 1.00 38.28  ? 125 PHE A CG  1 
ATOM   781  C CD1 . PHE A 1 125 ? 192.801 243.585 329.292 1.00 36.72  ? 125 PHE A CD1 1 
ATOM   782  C CD2 . PHE A 1 125 ? 192.578 241.480 328.208 1.00 36.08  ? 125 PHE A CD2 1 
ATOM   783  C CE1 . PHE A 1 125 ? 191.836 244.115 328.467 1.00 42.60  ? 125 PHE A CE1 1 
ATOM   784  C CE2 . PHE A 1 125 ? 191.613 242.004 327.381 1.00 28.07  ? 125 PHE A CE2 1 
ATOM   785  C CZ  . PHE A 1 125 ? 191.242 243.323 327.509 1.00 38.44  ? 125 PHE A CZ  1 
ATOM   786  N N   . THR A 1 126 ? 195.270 239.544 332.093 1.00 39.83  ? 126 THR A N   1 
ATOM   787  C CA  . THR A 1 126 ? 196.271 238.927 332.951 1.00 42.20  ? 126 THR A CA  1 
ATOM   788  C C   . THR A 1 126 ? 197.692 239.201 332.481 1.00 38.57  ? 126 THR A C   1 
ATOM   789  O O   . THR A 1 126 ? 198.580 239.414 333.312 1.00 34.45  ? 126 THR A O   1 
ATOM   790  C CB  . THR A 1 126 ? 196.050 237.416 333.030 1.00 40.73  ? 126 THR A CB  1 
ATOM   791  O OG1 . THR A 1 126 ? 194.652 237.137 333.163 1.00 34.09  ? 126 THR A OG1 1 
ATOM   792  C CG2 . THR A 1 126 ? 196.785 236.838 334.222 1.00 44.44  ? 126 THR A CG2 1 
ATOM   793  N N   . TYR A 1 127 ? 197.937 239.193 331.172 1.00 42.61  ? 127 TYR A N   1 
ATOM   794  C CA  . TYR A 1 127 ? 199.270 239.452 330.643 1.00 35.99  ? 127 TYR A CA  1 
ATOM   795  C C   . TYR A 1 127 ? 199.196 240.552 329.596 1.00 42.01  ? 127 TYR A C   1 
ATOM   796  O O   . TYR A 1 127 ? 198.157 240.754 328.969 1.00 60.07  ? 127 TYR A O   1 
ATOM   797  C CB  . TYR A 1 127 ? 199.884 238.193 330.034 1.00 36.87  ? 127 TYR A CB  1 
ATOM   798  C CG  . TYR A 1 127 ? 199.793 236.982 330.928 1.00 42.99  ? 127 TYR A CG  1 
ATOM   799  C CD1 . TYR A 1 127 ? 200.584 236.873 332.060 1.00 44.88  ? 127 TYR A CD1 1 
ATOM   800  C CD2 . TYR A 1 127 ? 198.919 235.947 330.638 1.00 32.12  ? 127 TYR A CD2 1 
ATOM   801  C CE1 . TYR A 1 127 ? 200.506 235.769 332.880 1.00 42.85  ? 127 TYR A CE1 1 
ATOM   802  C CE2 . TYR A 1 127 ? 198.833 234.840 331.451 1.00 36.32  ? 127 TYR A CE2 1 
ATOM   803  C CZ  . TYR A 1 127 ? 199.627 234.756 332.572 1.00 41.89  ? 127 TYR A CZ  1 
ATOM   804  O OH  . TYR A 1 127 ? 199.547 233.652 333.384 1.00 43.35  ? 127 TYR A OH  1 
ATOM   805  N N   . SER A 1 128 ? 200.309 241.258 329.399 1.00 37.12  ? 128 SER A N   1 
ATOM   806  C CA  . SER A 1 128 ? 200.306 242.389 328.480 1.00 37.47  ? 128 SER A CA  1 
ATOM   807  C C   . SER A 1 128 ? 201.720 242.705 328.015 1.00 36.66  ? 128 SER A C   1 
ATOM   808  O O   . SER A 1 128 ? 202.622 242.875 328.838 1.00 50.64  ? 128 SER A O   1 
ATOM   809  C CB  . SER A 1 128 ? 199.686 243.616 329.147 1.00 37.03  ? 128 SER A CB  1 
ATOM   810  O OG  . SER A 1 128 ? 200.367 243.932 330.347 1.00 44.47  ? 128 SER A OG  1 
ATOM   811  N N   . ARG A 1 129 ? 201.899 242.788 326.699 1.00 26.92  ? 129 ARG A N   1 
ATOM   812  C CA  . ARG A 1 129 ? 203.108 243.321 326.078 1.00 32.98  ? 129 ARG A CA  1 
ATOM   813  C C   . ARG A 1 129 ? 202.762 244.679 325.487 1.00 45.69  ? 129 ARG A C   1 
ATOM   814  O O   . ARG A 1 129 ? 202.005 244.755 324.516 1.00 53.01  ? 129 ARG A O   1 
ATOM   815  C CB  . ARG A 1 129 ? 203.630 242.404 324.976 1.00 40.42  ? 129 ARG A CB  1 
ATOM   816  C CG  . ARG A 1 129 ? 204.349 241.160 325.430 1.00 48.76  ? 129 ARG A CG  1 
ATOM   817  C CD  . ARG A 1 129 ? 204.797 240.349 324.222 1.00 42.61  ? 129 ARG A CD  1 
ATOM   818  N NE  . ARG A 1 129 ? 205.664 241.116 323.334 1.00 41.30  ? 129 ARG A NE  1 
ATOM   819  C CZ  . ARG A 1 129 ? 206.988 241.136 323.401 1.00 43.69  ? 129 ARG A CZ  1 
ATOM   820  N NH1 . ARG A 1 129 ? 207.648 240.443 324.314 1.00 37.40  ? 129 ARG A NH1 1 
ATOM   821  N NH2 . ARG A 1 129 ? 207.670 241.867 322.525 1.00 47.99  ? 129 ARG A NH2 1 
ATOM   822  N N   . PHE A 1 130 ? 203.322 245.747 326.043 1.00 41.06  ? 130 PHE A N   1 
ATOM   823  C CA  . PHE A 1 130 ? 203.074 247.070 325.492 1.00 34.53  ? 130 PHE A CA  1 
ATOM   824  C C   . PHE A 1 130 ? 204.317 247.931 325.610 1.00 45.59  ? 130 PHE A C   1 
ATOM   825  O O   . PHE A 1 130 ? 204.893 248.050 326.694 1.00 53.15  ? 130 PHE A O   1 
ATOM   826  C CB  . PHE A 1 130 ? 201.894 247.753 326.192 1.00 35.28  ? 130 PHE A CB  1 
ATOM   827  C CG  . PHE A 1 130 ? 202.055 247.894 327.677 1.00 29.93  ? 130 PHE A CG  1 
ATOM   828  C CD1 . PHE A 1 130 ? 202.651 249.016 328.220 1.00 36.16  ? 130 PHE A CD1 1 
ATOM   829  C CD2 . PHE A 1 130 ? 201.583 246.918 328.531 1.00 37.11  ? 130 PHE A CD2 1 
ATOM   830  C CE1 . PHE A 1 130 ? 202.789 249.152 329.582 1.00 38.11  ? 130 PHE A CE1 1 
ATOM   831  C CE2 . PHE A 1 130 ? 201.718 247.051 329.895 1.00 43.53  ? 130 PHE A CE2 1 
ATOM   832  C CZ  . PHE A 1 130 ? 202.322 248.168 330.420 1.00 44.44  ? 130 PHE A CZ  1 
ATOM   833  N N   . ASP A 1 131 ? 204.729 248.520 324.491 1.00 53.91  ? 131 ASP A N   1 
ATOM   834  C CA  . ASP A 1 131 ? 205.676 249.618 324.553 1.00 53.01  ? 131 ASP A CA  1 
ATOM   835  C C   . ASP A 1 131 ? 205.066 250.736 325.385 1.00 54.96  ? 131 ASP A C   1 
ATOM   836  O O   . ASP A 1 131 ? 203.849 250.837 325.526 1.00 60.34  ? 131 ASP A O   1 
ATOM   837  C CB  . ASP A 1 131 ? 206.012 250.122 323.152 1.00 49.42  ? 131 ASP A CB  1 
ATOM   838  C CG  . ASP A 1 131 ? 206.492 249.017 322.236 1.00 61.30  ? 131 ASP A CG  1 
ATOM   839  O OD1 . ASP A 1 131 ? 207.306 248.184 322.683 1.00 66.91  ? 131 ASP A OD1 1 
ATOM   840  O OD2 . ASP A 1 131 ? 206.050 248.977 321.070 1.00 66.12  ? 131 ASP A OD2 1 
ATOM   841  N N   . MET A 1 132 ? 205.916 251.581 325.946 1.00 52.05  ? 132 MET A N   1 
ATOM   842  C CA  . MET A 1 132 ? 205.452 252.626 326.842 1.00 54.21  ? 132 MET A CA  1 
ATOM   843  C C   . MET A 1 132 ? 205.882 253.987 326.320 1.00 50.89  ? 132 MET A C   1 
ATOM   844  O O   . MET A 1 132 ? 206.872 254.109 325.598 1.00 58.96  ? 132 MET A O   1 
ATOM   845  C CB  . MET A 1 132 ? 205.988 252.413 328.254 1.00 51.06  ? 132 MET A CB  1 
ATOM   846  C CG  . MET A 1 132 ? 205.327 253.291 329.286 1.00 52.18  ? 132 MET A CG  1 
ATOM   847  S SD  . MET A 1 132 ? 205.904 252.954 330.953 1.00 72.74  ? 132 MET A SD  1 
ATOM   848  C CE  . MET A 1 132 ? 207.657 253.214 330.748 1.00 61.72  ? 132 MET A CE  1 
ATOM   849  N N   . GLU A 1 133 ? 205.112 255.010 326.676 1.00 44.70  ? 133 GLU A N   1 
ATOM   850  C CA  . GLU A 1 133 ? 205.454 256.390 326.353 1.00 44.64  ? 133 GLU A CA  1 
ATOM   851  C C   . GLU A 1 133 ? 205.201 257.222 327.601 1.00 49.15  ? 133 GLU A C   1 
ATOM   852  O O   . GLU A 1 133 ? 204.052 257.360 328.030 1.00 62.96  ? 133 GLU A O   1 
ATOM   853  C CB  . GLU A 1 133 ? 204.631 256.899 325.171 1.00 46.09  ? 133 GLU A CB  1 
ATOM   854  C CG  . GLU A 1 133 ? 204.876 258.351 324.818 1.00 53.48  ? 133 GLU A CG  1 
ATOM   855  C CD  . GLU A 1 133 ? 204.025 258.818 323.657 1.00 60.50  ? 133 GLU A CD  1 
ATOM   856  O OE1 . GLU A 1 133 ? 203.339 257.976 323.044 1.00 58.63  ? 133 GLU A OE1 1 
ATOM   857  O OE2 . GLU A 1 133 ? 204.040 260.029 323.358 1.00 58.33  ? 133 GLU A OE2 1 
ATOM   858  N N   . LEU A 1 134 ? 206.265 257.756 328.190 1.00 37.50  ? 134 LEU A N   1 
ATOM   859  C CA  . LEU A 1 134 ? 206.172 258.523 329.422 1.00 43.04  ? 134 LEU A CA  1 
ATOM   860  C C   . LEU A 1 134 ? 206.299 260.005 329.110 1.00 43.16  ? 134 LEU A C   1 
ATOM   861  O O   . LEU A 1 134 ? 207.193 260.414 328.361 1.00 55.53  ? 134 LEU A O   1 
ATOM   862  C CB  . LEU A 1 134 ? 207.258 258.106 330.412 1.00 36.42  ? 134 LEU A CB  1 
ATOM   863  C CG  . LEU A 1 134 ? 207.120 256.707 331.004 1.00 41.32  ? 134 LEU A CG  1 
ATOM   864  C CD1 . LEU A 1 134 ? 208.322 256.380 331.862 1.00 50.57  ? 134 LEU A CD1 1 
ATOM   865  C CD2 . LEU A 1 134 ? 205.847 256.588 331.816 1.00 48.22  ? 134 LEU A CD2 1 
ATOM   866  N N   . THR A 1 135 ? 205.406 260.801 329.690 1.00 43.91  ? 135 THR A N   1 
ATOM   867  C CA  . THR A 1 135 ? 205.420 262.248 329.549 1.00 48.10  ? 135 THR A CA  1 
ATOM   868  C C   . THR A 1 135 ? 205.480 262.875 330.933 1.00 47.57  ? 135 THR A C   1 
ATOM   869  O O   . THR A 1 135 ? 204.698 262.517 331.815 1.00 59.22  ? 135 THR A O   1 
ATOM   870  C CB  . THR A 1 135 ? 204.184 262.743 328.798 1.00 51.68  ? 135 THR A CB  1 
ATOM   871  O OG1 . THR A 1 135 ? 204.080 262.059 327.544 1.00 48.83  ? 135 THR A OG1 1 
ATOM   872  C CG2 . THR A 1 135 ? 204.270 264.238 328.546 1.00 46.86  ? 135 THR A CG2 1 
ATOM   873  N N   . PHE A 1 136 ? 206.402 263.808 331.116 1.00 36.55  ? 136 PHE A N   1 
ATOM   874  C CA  . PHE A 1 136 ? 206.606 264.481 332.389 1.00 37.70  ? 136 PHE A CA  1 
ATOM   875  C C   . PHE A 1 136 ? 206.111 265.913 332.267 1.00 42.91  ? 136 PHE A C   1 
ATOM   876  O O   . PHE A 1 136 ? 206.580 266.666 331.403 1.00 53.64  ? 136 PHE A O   1 
ATOM   877  C CB  . PHE A 1 136 ? 208.079 264.451 332.793 1.00 48.75  ? 136 PHE A CB  1 
ATOM   878  C CG  . PHE A 1 136 ? 208.691 263.083 332.735 1.00 51.53  ? 136 PHE A CG  1 
ATOM   879  C CD1 . PHE A 1 136 ? 209.209 262.593 331.550 1.00 52.32  ? 136 PHE A CD1 1 
ATOM   880  C CD2 . PHE A 1 136 ? 208.749 262.286 333.863 1.00 52.28  ? 136 PHE A CD2 1 
ATOM   881  C CE1 . PHE A 1 136 ? 209.773 261.337 331.491 1.00 52.25  ? 136 PHE A CE1 1 
ATOM   882  C CE2 . PHE A 1 136 ? 209.311 261.030 333.808 1.00 52.00  ? 136 PHE A CE2 1 
ATOM   883  C CZ  . PHE A 1 136 ? 209.823 260.556 332.621 1.00 54.95  ? 136 PHE A CZ  1 
ATOM   884  N N   . VAL A 1 137 ? 205.162 266.273 333.127 1.00 53.76  ? 137 VAL A N   1 
ATOM   885  C CA  . VAL A 1 137 ? 204.617 267.623 333.215 1.00 49.57  ? 137 VAL A CA  1 
ATOM   886  C C   . VAL A 1 137 ? 205.055 268.198 334.552 1.00 52.39  ? 137 VAL A C   1 
ATOM   887  O O   . VAL A 1 137 ? 204.716 267.654 335.609 1.00 60.84  ? 137 VAL A O   1 
ATOM   888  C CB  . VAL A 1 137 ? 203.086 267.625 333.093 1.00 42.46  ? 137 VAL A CB  1 
ATOM   889  C CG1 . VAL A 1 137 ? 202.540 269.023 333.297 1.00 47.23  ? 137 VAL A CG1 1 
ATOM   890  C CG2 . VAL A 1 137 ? 202.656 267.073 331.747 1.00 49.99  ? 137 VAL A CG2 1 
ATOM   891  N N   . VAL A 1 138 ? 205.806 269.289 334.513 1.00 48.87  ? 138 VAL A N   1 
ATOM   892  C CA  . VAL A 1 138 ? 206.379 269.874 335.716 1.00 44.04  ? 138 VAL A CA  1 
ATOM   893  C C   . VAL A 1 138 ? 205.657 271.172 336.034 1.00 50.69  ? 138 VAL A C   1 
ATOM   894  O O   . VAL A 1 138 ? 205.216 271.902 335.140 1.00 58.99  ? 138 VAL A O   1 
ATOM   895  C CB  . VAL A 1 138 ? 207.892 270.123 335.565 1.00 46.64  ? 138 VAL A CB  1 
ATOM   896  C CG1 . VAL A 1 138 ? 208.503 270.475 336.907 1.00 49.79  ? 138 VAL A CG1 1 
ATOM   897  C CG2 . VAL A 1 138 ? 208.571 268.909 334.958 1.00 53.42  ? 138 VAL A CG2 1 
ATOM   898  N N   . THR A 1 139 ? 205.535 271.453 337.327 1.00 55.83  ? 139 THR A N   1 
ATOM   899  C CA  . THR A 1 139 ? 204.992 272.711 337.808 1.00 57.87  ? 139 THR A CA  1 
ATOM   900  C C   . THR A 1 139 ? 205.794 273.139 339.026 1.00 60.38  ? 139 THR A C   1 
ATOM   901  O O   . THR A 1 139 ? 206.405 272.315 339.708 1.00 65.81  ? 139 THR A O   1 
ATOM   902  C CB  . THR A 1 139 ? 203.509 272.595 338.170 1.00 54.42  ? 139 THR A CB  1 
ATOM   903  O OG1 . THR A 1 139 ? 203.365 271.793 339.348 1.00 62.04  ? 139 THR A OG1 1 
ATOM   904  C CG2 . THR A 1 139 ? 202.734 271.960 337.033 1.00 56.56  ? 139 THR A CG2 1 
ATOM   905  N N   . ALA A 1 140 ? 205.789 274.442 339.295 1.00 59.40  ? 140 ALA A N   1 
ATOM   906  C CA  . ALA A 1 140 ? 206.570 274.996 340.388 1.00 56.63  ? 140 ALA A CA  1 
ATOM   907  C C   . ALA A 1 140 ? 205.758 276.062 341.107 1.00 57.50  ? 140 ALA A C   1 
ATOM   908  O O   . ALA A 1 140 ? 204.754 276.562 340.595 1.00 64.57  ? 140 ALA A O   1 
ATOM   909  C CB  . ALA A 1 140 ? 207.893 275.588 339.891 1.00 60.11  ? 140 ALA A CB  1 
ATOM   910  N N   . ASN A 1 141 ? 206.208 276.399 342.312 1.00 72.26  ? 141 ASN A N   1 
ATOM   911  C CA  . ASN A 1 141 ? 205.533 277.412 343.110 1.00 74.40  ? 141 ASN A CA  1 
ATOM   912  C C   . ASN A 1 141 ? 206.420 277.807 344.280 1.00 77.30  ? 141 ASN A C   1 
ATOM   913  O O   . ASN A 1 141 ? 207.126 276.966 344.842 1.00 80.00  ? 141 ASN A O   1 
ATOM   914  C CB  . ASN A 1 141 ? 204.183 276.899 343.623 1.00 74.54  ? 141 ASN A CB  1 
ATOM   915  C CG  . ASN A 1 141 ? 204.333 275.806 344.653 1.00 80.60  ? 141 ASN A CG  1 
ATOM   916  O OD1 . ASN A 1 141 ? 204.690 274.676 344.327 1.00 83.18  ? 141 ASN A OD1 1 
ATOM   917  N ND2 . ASN A 1 141 ? 204.054 276.135 345.909 1.00 80.25  ? 141 ASN A ND2 1 
ATOM   918  N N   . PHE A 1 142 ? 206.374 279.086 344.639 1.00 79.00  ? 142 PHE A N   1 
ATOM   919  C CA  . PHE A 1 142 ? 207.066 279.567 345.823 1.00 76.89  ? 142 PHE A CA  1 
ATOM   920  C C   . PHE A 1 142 ? 206.311 279.150 347.079 1.00 82.75  ? 142 PHE A C   1 
ATOM   921  O O   . PHE A 1 142 ? 205.098 278.929 347.056 1.00 87.61  ? 142 PHE A O   1 
ATOM   922  C CB  . PHE A 1 142 ? 207.208 281.088 345.785 1.00 76.07  ? 142 PHE A CB  1 
ATOM   923  C CG  . PHE A 1 142 ? 207.964 281.595 344.593 1.00 80.06  ? 142 PHE A CG  1 
ATOM   924  C CD1 . PHE A 1 142 ? 209.336 281.445 344.513 1.00 82.60  ? 142 PHE A CD1 1 
ATOM   925  C CD2 . PHE A 1 142 ? 207.305 282.230 343.557 1.00 82.36  ? 142 PHE A CD2 1 
ATOM   926  C CE1 . PHE A 1 142 ? 210.035 281.911 343.420 1.00 82.23  ? 142 PHE A CE1 1 
ATOM   927  C CE2 . PHE A 1 142 ? 208.001 282.699 342.462 1.00 81.47  ? 142 PHE A CE2 1 
ATOM   928  C CZ  . PHE A 1 142 ? 209.367 282.540 342.395 1.00 81.03  ? 142 PHE A CZ  1 
ATOM   929  N N   . THR A 1 143 ? 207.044 279.045 348.181 1.00 92.13  ? 143 THR A N   1 
ATOM   930  C CA  . THR A 1 143 ? 206.475 278.634 349.459 1.00 95.16  ? 143 THR A CA  1 
ATOM   931  C C   . THR A 1 143 ? 206.622 279.684 350.546 1.00 96.27  ? 143 THR A C   1 
ATOM   932  O O   . THR A 1 143 ? 205.673 279.921 351.297 1.00 95.63  ? 143 THR A O   1 
ATOM   933  C CB  . THR A 1 143 ? 207.130 277.328 349.930 1.00 97.48  ? 143 THR A CB  1 
ATOM   934  O OG1 . THR A 1 143 ? 206.926 276.305 348.947 1.00 94.68  ? 143 THR A OG1 1 
ATOM   935  C CG2 . THR A 1 143 ? 206.537 276.879 351.257 1.00 95.72  ? 143 THR A CG2 1 
ATOM   936  N N   . GLU A 1 144 ? 207.784 280.319 350.654 1.00 106.06 ? 144 GLU A N   1 
ATOM   937  C CA  . GLU A 1 144 ? 207.983 281.342 351.669 1.00 107.61 ? 144 GLU A CA  1 
ATOM   938  C C   . GLU A 1 144 ? 207.166 282.584 351.338 1.00 108.61 ? 144 GLU A C   1 
ATOM   939  O O   . GLU A 1 144 ? 207.012 282.953 350.171 1.00 106.73 ? 144 GLU A O   1 
ATOM   940  C CB  . GLU A 1 144 ? 209.464 281.701 351.775 1.00 107.41 ? 144 GLU A CB  1 
ATOM   941  C CG  . GLU A 1 144 ? 210.350 280.539 352.188 1.00 108.10 ? 144 GLU A CG  1 
ATOM   942  C CD  . GLU A 1 144 ? 211.815 280.920 352.258 1.00 108.88 ? 144 GLU A CD  1 
ATOM   943  O OE1 . GLU A 1 144 ? 212.167 282.019 351.783 1.00 109.09 ? 144 GLU A OE1 1 
ATOM   944  O OE2 . GLU A 1 144 ? 212.613 280.120 352.789 1.00 107.31 ? 144 GLU A OE2 1 
ATOM   945  N N   . THR A 1 145 ? 206.639 283.231 352.380 1.00 117.11 ? 145 THR A N   1 
ATOM   946  C CA  . THR A 1 145 ? 205.853 284.442 352.170 1.00 117.15 ? 145 THR A CA  1 
ATOM   947  C C   . THR A 1 145 ? 206.644 285.489 351.399 1.00 117.40 ? 145 THR A C   1 
ATOM   948  O O   . THR A 1 145 ? 206.065 286.256 350.622 1.00 116.17 ? 145 THR A O   1 
ATOM   949  C CB  . THR A 1 145 ? 205.392 285.016 353.511 1.00 115.97 ? 145 THR A CB  1 
ATOM   950  O OG1 . THR A 1 145 ? 206.532 285.296 354.333 1.00 116.27 ? 145 THR A OG1 1 
ATOM   951  C CG2 . THR A 1 145 ? 204.477 284.034 354.228 1.00 113.61 ? 145 THR A CG2 1 
ATOM   952  N N   . ASN A 1 146 ? 207.957 285.538 351.599 1.00 118.47 ? 146 ASN A N   1 
ATOM   953  C CA  . ASN A 1 146 ? 208.797 286.446 350.832 1.00 119.55 ? 146 ASN A CA  1 
ATOM   954  C C   . ASN A 1 146 ? 208.638 286.169 349.345 1.00 119.02 ? 146 ASN A C   1 
ATOM   955  O O   . ASN A 1 146 ? 208.973 285.081 348.868 1.00 117.81 ? 146 ASN A O   1 
ATOM   956  C CB  . ASN A 1 146 ? 210.258 286.290 351.250 1.00 118.13 ? 146 ASN A CB  1 
ATOM   957  C CG  . ASN A 1 146 ? 211.214 286.982 350.297 1.00 116.75 ? 146 ASN A CG  1 
ATOM   958  O OD1 . ASN A 1 146 ? 210.863 287.976 349.660 1.00 116.73 ? 146 ASN A OD1 1 
ATOM   959  N ND2 . ASN A 1 146 ? 212.428 286.455 350.189 1.00 115.39 ? 146 ASN A ND2 1 
ATOM   960  N N   . ASN A 1 147 ? 208.120 287.154 348.614 1.00 120.51 ? 147 ASN A N   1 
ATOM   961  C CA  . ASN A 1 147 ? 208.002 287.053 347.161 1.00 120.56 ? 147 ASN A CA  1 
ATOM   962  C C   . ASN A 1 147 ? 209.358 287.406 346.562 1.00 120.95 ? 147 ASN A C   1 
ATOM   963  O O   . ASN A 1 147 ? 209.617 288.530 346.124 1.00 119.54 ? 147 ASN A O   1 
ATOM   964  C CB  . ASN A 1 147 ? 206.896 287.961 346.642 1.00 121.17 ? 147 ASN A CB  1 
ATOM   965  C CG  . ASN A 1 147 ? 205.518 287.502 347.070 1.00 123.18 ? 147 ASN A CG  1 
ATOM   966  O OD1 . ASN A 1 147 ? 204.757 288.259 347.674 1.00 122.26 ? 147 ASN A OD1 1 
ATOM   967  N ND2 . ASN A 1 147 ? 205.188 286.254 346.758 1.00 122.91 ? 147 ASN A ND2 1 
ATOM   968  N N   . GLY A 1 148 ? 210.248 286.417 346.564 1.00 112.38 ? 148 GLY A N   1 
ATOM   969  C CA  . GLY A 1 148 ? 211.579 286.575 346.022 1.00 110.50 ? 148 GLY A CA  1 
ATOM   970  C C   . GLY A 1 148 ? 211.636 286.229 344.548 1.00 110.14 ? 148 GLY A C   1 
ATOM   971  O O   . GLY A 1 148 ? 210.619 286.057 343.874 1.00 108.93 ? 148 GLY A O   1 
ATOM   972  N N   . HIS A 1 149 ? 212.861 286.127 344.046 1.00 105.73 ? 149 HIS A N   1 
ATOM   973  C CA  . HIS A 1 149 ? 213.113 285.810 342.650 1.00 104.93 ? 149 HIS A CA  1 
ATOM   974  C C   . HIS A 1 149 ? 213.817 284.466 342.545 1.00 103.30 ? 149 HIS A C   1 
ATOM   975  O O   . HIS A 1 149 ? 214.737 284.172 343.314 1.00 104.39 ? 149 HIS A O   1 
ATOM   976  C CB  . HIS A 1 149 ? 213.962 286.893 341.981 1.00 106.62 ? 149 HIS A CB  1 
ATOM   977  C CG  . HIS A 1 149 ? 213.284 288.225 341.890 1.00 108.96 ? 149 HIS A CG  1 
ATOM   978  N ND1 . HIS A 1 149 ? 213.683 289.317 342.629 1.00 109.96 ? 149 HIS A ND1 1 
ATOM   979  C CD2 . HIS A 1 149 ? 212.235 288.642 341.142 1.00 108.35 ? 149 HIS A CD2 1 
ATOM   980  C CE1 . HIS A 1 149 ? 212.909 290.348 342.343 1.00 106.05 ? 149 HIS A CE1 1 
ATOM   981  N NE2 . HIS A 1 149 ? 212.022 289.965 341.443 1.00 107.87 ? 149 HIS A NE2 1 
ATOM   982  N N   . ALA A 1 150 ? 213.375 283.652 341.590 1.00 84.72  ? 150 ALA A N   1 
ATOM   983  C CA  . ALA A 1 150 ? 214.002 282.369 341.302 1.00 84.62  ? 150 ALA A CA  1 
ATOM   984  C C   . ALA A 1 150 ? 214.150 282.249 339.796 1.00 86.96  ? 150 ALA A C   1 
ATOM   985  O O   . ALA A 1 150 ? 213.150 282.272 339.072 1.00 85.44  ? 150 ALA A O   1 
ATOM   986  C CB  . ALA A 1 150 ? 213.176 281.205 341.854 1.00 86.19  ? 150 ALA A CB  1 
ATOM   987  N N   . LEU A 1 151 ? 215.385 282.119 339.326 1.00 85.33  ? 151 LEU A N   1 
ATOM   988  C CA  . LEU A 1 151 ? 215.613 281.986 337.899 1.00 82.58  ? 151 LEU A CA  1 
ATOM   989  C C   . LEU A 1 151 ? 215.069 280.651 337.400 1.00 79.95  ? 151 LEU A C   1 
ATOM   990  O O   . LEU A 1 151 ? 214.871 279.704 338.165 1.00 80.42  ? 151 LEU A O   1 
ATOM   991  C CB  . LEU A 1 151 ? 217.102 282.105 337.580 1.00 83.98  ? 151 LEU A CB  1 
ATOM   992  C CG  . LEU A 1 151 ? 217.733 283.443 337.965 1.00 83.65  ? 151 LEU A CG  1 
ATOM   993  C CD1 . LEU A 1 151 ? 219.221 283.432 337.678 1.00 86.39  ? 151 LEU A CD1 1 
ATOM   994  C CD2 . LEU A 1 151 ? 217.057 284.587 337.230 1.00 79.90  ? 151 LEU A CD2 1 
ATOM   995  N N   . ASN A 1 152 ? 214.819 280.590 336.095 1.00 72.14  ? 152 ASN A N   1 
ATOM   996  C CA  . ASN A 1 152 ? 214.230 279.399 335.501 1.00 75.33  ? 152 ASN A CA  1 
ATOM   997  C C   . ASN A 1 152 ? 215.039 278.166 335.876 1.00 73.65  ? 152 ASN A C   1 
ATOM   998  O O   . ASN A 1 152 ? 216.265 278.147 335.738 1.00 74.06  ? 152 ASN A O   1 
ATOM   999  C CB  . ASN A 1 152 ? 214.168 279.552 333.981 1.00 77.53  ? 152 ASN A CB  1 
ATOM   1000 C CG  . ASN A 1 152 ? 213.476 278.390 333.310 1.00 77.69  ? 152 ASN A CG  1 
ATOM   1001 O OD1 . ASN A 1 152 ? 214.108 277.393 332.966 1.00 79.26  ? 152 ASN A OD1 1 
ATOM   1002 N ND2 . ASN A 1 152 ? 212.169 278.511 333.118 1.00 73.38  ? 152 ASN A ND2 1 
ATOM   1003 N N   . GLN A 1 153 ? 214.346 277.138 336.351 1.00 66.31  ? 153 GLN A N   1 
ATOM   1004 C CA  . GLN A 1 153 ? 214.983 275.939 336.870 1.00 63.13  ? 153 GLN A CA  1 
ATOM   1005 C C   . GLN A 1 153 ? 215.091 274.872 335.791 1.00 66.02  ? 153 GLN A C   1 
ATOM   1006 O O   . GLN A 1 153 ? 214.305 274.840 334.841 1.00 66.25  ? 153 GLN A O   1 
ATOM   1007 C CB  . GLN A 1 153 ? 214.205 275.385 338.062 1.00 63.09  ? 153 GLN A CB  1 
ATOM   1008 C CG  . GLN A 1 153 ? 214.196 276.301 339.265 1.00 65.88  ? 153 GLN A CG  1 
ATOM   1009 C CD  . GLN A 1 153 ? 213.498 275.682 340.453 1.00 69.12  ? 153 GLN A CD  1 
ATOM   1010 O OE1 . GLN A 1 153 ? 212.781 274.692 340.318 1.00 66.89  ? 153 GLN A OE1 1 
ATOM   1011 N NE2 . GLN A 1 153 ? 213.708 276.259 341.628 1.00 72.44  ? 153 GLN A NE2 1 
ATOM   1012 N N   . VAL A 1 154 ? 216.077 273.996 335.953 1.00 59.61  ? 154 VAL A N   1 
ATOM   1013 C CA  . VAL A 1 154 ? 216.302 272.870 335.055 1.00 56.52  ? 154 VAL A CA  1 
ATOM   1014 C C   . VAL A 1 154 ? 216.214 271.602 335.888 1.00 58.14  ? 154 VAL A C   1 
ATOM   1015 O O   . VAL A 1 154 ? 216.928 271.460 336.888 1.00 57.42  ? 154 VAL A O   1 
ATOM   1016 C CB  . VAL A 1 154 ? 217.660 272.968 334.345 1.00 53.75  ? 154 VAL A CB  1 
ATOM   1017 C CG1 . VAL A 1 154 ? 217.753 271.942 333.232 1.00 52.45  ? 154 VAL A CG1 1 
ATOM   1018 C CG2 . VAL A 1 154 ? 217.875 274.366 333.801 1.00 63.50  ? 154 VAL A CG2 1 
ATOM   1019 N N   . TYR A 1 155 ? 215.343 270.685 335.480 1.00 59.28  ? 155 TYR A N   1 
ATOM   1020 C CA  . TYR A 1 155 ? 215.114 269.443 336.200 1.00 54.24  ? 155 TYR A CA  1 
ATOM   1021 C C   . TYR A 1 155 ? 215.805 268.291 335.488 1.00 50.59  ? 155 TYR A C   1 
ATOM   1022 O O   . TYR A 1 155 ? 215.749 268.184 334.262 1.00 53.25  ? 155 TYR A O   1 
ATOM   1023 C CB  . TYR A 1 155 ? 213.618 269.149 336.316 1.00 52.08  ? 155 TYR A CB  1 
ATOM   1024 C CG  . TYR A 1 155 ? 212.865 270.172 337.126 1.00 53.07  ? 155 TYR A CG  1 
ATOM   1025 C CD1 . TYR A 1 155 ? 212.774 270.060 338.504 1.00 56.51  ? 155 TYR A CD1 1 
ATOM   1026 C CD2 . TYR A 1 155 ? 212.246 271.249 336.515 1.00 59.09  ? 155 TYR A CD2 1 
ATOM   1027 C CE1 . TYR A 1 155 ? 212.089 270.993 339.250 1.00 57.45  ? 155 TYR A CE1 1 
ATOM   1028 C CE2 . TYR A 1 155 ? 211.559 272.187 337.254 1.00 62.04  ? 155 TYR A CE2 1 
ATOM   1029 C CZ  . TYR A 1 155 ? 211.483 272.053 338.619 1.00 59.46  ? 155 TYR A CZ  1 
ATOM   1030 O OH  . TYR A 1 155 ? 210.800 272.987 339.359 1.00 63.43  ? 155 TYR A OH  1 
ATOM   1031 N N   . GLN A 1 156 ? 216.455 267.432 336.263 1.00 51.40  ? 156 GLN A N   1 
ATOM   1032 C CA  . GLN A 1 156 ? 217.049 266.209 335.747 1.00 54.98  ? 156 GLN A CA  1 
ATOM   1033 C C   . GLN A 1 156 ? 216.187 265.032 336.166 1.00 56.32  ? 156 GLN A C   1 
ATOM   1034 O O   . GLN A 1 156 ? 215.844 264.896 337.346 1.00 65.68  ? 156 GLN A O   1 
ATOM   1035 C CB  . GLN A 1 156 ? 218.477 266.016 336.255 1.00 55.70  ? 156 GLN A CB  1 
ATOM   1036 C CG  . GLN A 1 156 ? 219.168 264.814 335.638 1.00 51.41  ? 156 GLN A CG  1 
ATOM   1037 C CD  . GLN A 1 156 ? 220.575 264.624 336.149 1.00 55.54  ? 156 GLN A CD  1 
ATOM   1038 O OE1 . GLN A 1 156 ? 220.891 264.990 337.280 1.00 59.85  ? 156 GLN A OE1 1 
ATOM   1039 N NE2 . GLN A 1 156 ? 221.433 264.055 335.315 1.00 59.12  ? 156 GLN A NE2 1 
ATOM   1040 N N   . ILE A 1 157 ? 215.843 264.191 335.197 1.00 44.94  ? 157 ILE A N   1 
ATOM   1041 C CA  . ILE A 1 157 ? 215.008 263.014 335.401 1.00 48.00  ? 157 ILE A CA  1 
ATOM   1042 C C   . ILE A 1 157 ? 215.841 261.832 334.924 1.00 53.12  ? 157 ILE A C   1 
ATOM   1043 O O   . ILE A 1 157 ? 216.007 261.637 333.717 1.00 61.46  ? 157 ILE A O   1 
ATOM   1044 C CB  . ILE A 1 157 ? 213.683 263.108 334.637 1.00 47.26  ? 157 ILE A CB  1 
ATOM   1045 C CG1 . ILE A 1 157 ? 213.200 264.559 334.576 1.00 52.24  ? 157 ILE A CG1 1 
ATOM   1046 C CG2 . ILE A 1 157 ? 212.625 262.253 335.295 1.00 51.54  ? 157 ILE A CG2 1 
ATOM   1047 C CD1 . ILE A 1 157 ? 211.880 264.730 333.866 1.00 50.16  ? 157 ILE A CD1 1 
ATOM   1048 N N   . MET A 1 158 ? 216.377 261.052 335.858 1.00 54.18  ? 158 MET A N   1 
ATOM   1049 C CA  . MET A 1 158 ? 217.318 259.982 335.557 1.00 45.95  ? 158 MET A CA  1 
ATOM   1050 C C   . MET A 1 158 ? 216.691 258.639 335.897 1.00 47.26  ? 158 MET A C   1 
ATOM   1051 O O   . MET A 1 158 ? 216.083 258.482 336.959 1.00 47.65  ? 158 MET A O   1 
ATOM   1052 C CB  . MET A 1 158 ? 218.617 260.172 336.343 1.00 51.92  ? 158 MET A CB  1 
ATOM   1053 C CG  . MET A 1 158 ? 219.648 259.080 336.125 1.00 59.99  ? 158 MET A CG  1 
ATOM   1054 S SD  . MET A 1 158 ? 221.144 259.328 337.095 1.00 64.37  ? 158 MET A SD  1 
ATOM   1055 C CE  . MET A 1 158 ? 220.500 259.175 338.755 1.00 54.79  ? 158 MET A CE  1 
ATOM   1056 N N   . TYR A 1 159 ? 216.849 257.671 335.001 1.00 46.65  ? 159 TYR A N   1 
ATOM   1057 C CA  . TYR A 1 159 ? 216.303 256.332 335.181 1.00 48.03  ? 159 TYR A CA  1 
ATOM   1058 C C   . TYR A 1 159 ? 217.392 255.424 335.733 1.00 47.14  ? 159 TYR A C   1 
ATOM   1059 O O   . TYR A 1 159 ? 218.445 255.266 335.108 1.00 62.95  ? 159 TYR A O   1 
ATOM   1060 C CB  . TYR A 1 159 ? 215.772 255.793 333.857 1.00 45.67  ? 159 TYR A CB  1 
ATOM   1061 C CG  . TYR A 1 159 ? 215.368 254.342 333.885 1.00 45.80  ? 159 TYR A CG  1 
ATOM   1062 C CD1 . TYR A 1 159 ? 214.528 253.855 334.872 1.00 50.04  ? 159 TYR A CD1 1 
ATOM   1063 C CD2 . TYR A 1 159 ? 215.811 253.461 332.910 1.00 46.53  ? 159 TYR A CD2 1 
ATOM   1064 C CE1 . TYR A 1 159 ? 214.152 252.529 334.896 1.00 49.89  ? 159 TYR A CE1 1 
ATOM   1065 C CE2 . TYR A 1 159 ? 215.439 252.134 332.925 1.00 49.42  ? 159 TYR A CE2 1 
ATOM   1066 C CZ  . TYR A 1 159 ? 214.610 251.673 333.921 1.00 51.20  ? 159 TYR A CZ  1 
ATOM   1067 O OH  . TYR A 1 159 ? 214.232 250.352 333.943 1.00 57.30  ? 159 TYR A OH  1 
ATOM   1068 N N   . VAL A 1 160 ? 217.140 254.826 336.894 1.00 39.67  ? 160 VAL A N   1 
ATOM   1069 C CA  . VAL A 1 160 ? 218.121 253.961 337.539 1.00 45.67  ? 160 VAL A CA  1 
ATOM   1070 C C   . VAL A 1 160 ? 217.614 252.528 337.444 1.00 49.99  ? 160 VAL A C   1 
ATOM   1071 O O   . VAL A 1 160 ? 216.762 252.124 338.249 1.00 60.64  ? 160 VAL A O   1 
ATOM   1072 C CB  . VAL A 1 160 ? 218.348 254.376 339.000 1.00 46.60  ? 160 VAL A CB  1 
ATOM   1073 C CG1 . VAL A 1 160 ? 219.501 253.606 339.606 1.00 51.09  ? 160 VAL A CG1 1 
ATOM   1074 C CG2 . VAL A 1 160 ? 218.593 255.867 339.093 1.00 46.38  ? 160 VAL A CG2 1 
ATOM   1075 N N   . PRO A 1 161 ? 218.096 251.725 336.500 1.00 42.99  ? 161 PRO A N   1 
ATOM   1076 C CA  . PRO A 1 161 ? 217.599 250.355 336.371 1.00 42.75  ? 161 PRO A CA  1 
ATOM   1077 C C   . PRO A 1 161 ? 217.859 249.564 337.638 1.00 46.64  ? 161 PRO A C   1 
ATOM   1078 O O   . PRO A 1 161 ? 218.517 250.058 338.566 1.00 45.03  ? 161 PRO A O   1 
ATOM   1079 C CB  . PRO A 1 161 ? 218.400 249.797 335.187 1.00 47.66  ? 161 PRO A CB  1 
ATOM   1080 C CG  . PRO A 1 161 ? 218.812 250.986 334.415 1.00 42.14  ? 161 PRO A CG  1 
ATOM   1081 C CD  . PRO A 1 161 ? 219.039 252.065 335.422 1.00 39.21  ? 161 PRO A CD  1 
ATOM   1082 N N   . PRO A 1 162 ? 217.359 248.335 337.723 1.00 51.83  ? 162 PRO A N   1 
ATOM   1083 C CA  . PRO A 1 162 ? 217.536 247.560 338.957 1.00 50.83  ? 162 PRO A CA  1 
ATOM   1084 C C   . PRO A 1 162 ? 218.988 247.175 339.179 1.00 56.94  ? 162 PRO A C   1 
ATOM   1085 O O   . PRO A 1 162 ? 219.526 246.323 338.467 1.00 57.49  ? 162 PRO A O   1 
ATOM   1086 C CB  . PRO A 1 162 ? 216.653 246.324 338.733 1.00 49.28  ? 162 PRO A CB  1 
ATOM   1087 C CG  . PRO A 1 162 ? 215.816 246.630 337.528 1.00 54.75  ? 162 PRO A CG  1 
ATOM   1088 C CD  . PRO A 1 162 ? 216.603 247.586 336.709 1.00 57.08  ? 162 PRO A CD  1 
ATOM   1089 N N   . GLY A 1 163 ? 219.628 247.797 340.166 1.00 60.60  ? 163 GLY A N   1 
ATOM   1090 C CA  . GLY A 1 163 ? 221.012 247.499 340.479 1.00 58.22  ? 163 GLY A CA  1 
ATOM   1091 C C   . GLY A 1 163 ? 221.909 248.716 340.450 1.00 54.00  ? 163 GLY A C   1 
ATOM   1092 O O   . GLY A 1 163 ? 222.836 248.827 341.257 1.00 56.82  ? 163 GLY A O   1 
ATOM   1093 N N   . ALA A 1 164 ? 221.646 249.637 339.528 1.00 56.82  ? 164 ALA A N   1 
ATOM   1094 C CA  . ALA A 1 164 ? 222.469 250.828 339.424 1.00 60.51  ? 164 ALA A CA  1 
ATOM   1095 C C   . ALA A 1 164 ? 222.376 251.637 340.717 1.00 63.66  ? 164 ALA A C   1 
ATOM   1096 O O   . ALA A 1 164 ? 221.347 251.616 341.399 1.00 66.40  ? 164 ALA A O   1 
ATOM   1097 C CB  . ALA A 1 164 ? 222.030 251.678 338.235 1.00 56.71  ? 164 ALA A CB  1 
ATOM   1098 N N   . PRO A 1 165 ? 223.438 252.351 341.086 1.00 61.73  ? 165 PRO A N   1 
ATOM   1099 C CA  . PRO A 1 165 ? 223.432 253.057 342.371 1.00 63.46  ? 165 PRO A CA  1 
ATOM   1100 C C   . PRO A 1 165 ? 222.302 254.071 342.450 1.00 62.27  ? 165 PRO A C   1 
ATOM   1101 O O   . PRO A 1 165 ? 221.985 254.755 341.475 1.00 65.87  ? 165 PRO A O   1 
ATOM   1102 C CB  . PRO A 1 165 ? 224.805 253.736 342.409 1.00 63.18  ? 165 PRO A CB  1 
ATOM   1103 C CG  . PRO A 1 165 ? 225.204 253.861 340.985 1.00 60.34  ? 165 PRO A CG  1 
ATOM   1104 C CD  . PRO A 1 165 ? 224.640 252.660 340.294 1.00 58.12  ? 165 PRO A CD  1 
ATOM   1105 N N   . VAL A 1 166 ? 221.699 254.164 343.629 1.00 54.34  ? 166 VAL A N   1 
ATOM   1106 C CA  . VAL A 1 166 ? 220.620 255.112 343.889 1.00 59.47  ? 166 VAL A CA  1 
ATOM   1107 C C   . VAL A 1 166 ? 221.247 256.401 344.412 1.00 68.25  ? 166 VAL A C   1 
ATOM   1108 O O   . VAL A 1 166 ? 221.974 256.353 345.417 1.00 67.27  ? 166 VAL A O   1 
ATOM   1109 C CB  . VAL A 1 166 ? 219.612 254.549 344.896 1.00 57.07  ? 166 VAL A CB  1 
ATOM   1110 C CG1 . VAL A 1 166 ? 218.585 255.606 345.267 1.00 55.68  ? 166 VAL A CG1 1 
ATOM   1111 C CG2 . VAL A 1 166 ? 218.933 253.315 344.332 1.00 62.19  ? 166 VAL A CG2 1 
ATOM   1112 N N   . PRO A 1 167 ? 221.011 257.550 343.779 1.00 64.07  ? 167 PRO A N   1 
ATOM   1113 C CA  . PRO A 1 167 ? 221.550 258.798 344.328 1.00 62.09  ? 167 PRO A CA  1 
ATOM   1114 C C   . PRO A 1 167 ? 221.071 259.022 345.754 1.00 59.85  ? 167 PRO A C   1 
ATOM   1115 O O   . PRO A 1 167 ? 219.892 258.852 346.070 1.00 60.89  ? 167 PRO A O   1 
ATOM   1116 C CB  . PRO A 1 167 ? 221.015 259.873 343.374 1.00 62.73  ? 167 PRO A CB  1 
ATOM   1117 C CG  . PRO A 1 167 ? 219.937 259.218 342.588 1.00 60.00  ? 167 PRO A CG  1 
ATOM   1118 C CD  . PRO A 1 167 ? 220.291 257.778 342.515 1.00 57.21  ? 167 PRO A CD  1 
ATOM   1119 N N   . GLU A 1 168 ? 222.008 259.411 346.620 1.00 70.36  ? 168 GLU A N   1 
ATOM   1120 C CA  . GLU A 1 168 ? 221.711 259.709 348.012 1.00 74.61  ? 168 GLU A CA  1 
ATOM   1121 C C   . GLU A 1 168 ? 221.784 261.193 348.331 1.00 79.17  ? 168 GLU A C   1 
ATOM   1122 O O   . GLU A 1 168 ? 221.131 261.637 349.281 1.00 80.13  ? 168 GLU A O   1 
ATOM   1123 C CB  . GLU A 1 168 ? 222.679 258.956 348.935 1.00 76.88  ? 168 GLU A CB  1 
ATOM   1124 C CG  . GLU A 1 168 ? 222.731 257.459 348.685 1.00 78.39  ? 168 GLU A CG  1 
ATOM   1125 C CD  . GLU A 1 168 ? 223.775 256.763 349.536 1.00 83.87  ? 168 GLU A CD  1 
ATOM   1126 O OE1 . GLU A 1 168 ? 224.362 257.425 350.418 1.00 83.49  ? 168 GLU A OE1 1 
ATOM   1127 O OE2 . GLU A 1 168 ? 224.011 255.556 349.321 1.00 82.80  ? 168 GLU A OE2 1 
ATOM   1128 N N   . LYS A 1 169 ? 222.558 261.959 347.569 1.00 77.18  ? 169 LYS A N   1 
ATOM   1129 C CA  . LYS A 1 169 ? 222.592 263.409 347.659 1.00 75.24  ? 169 LYS A CA  1 
ATOM   1130 C C   . LYS A 1 169 ? 222.299 263.991 346.284 1.00 75.31  ? 169 LYS A C   1 
ATOM   1131 O O   . LYS A 1 169 ? 222.568 263.362 345.257 1.00 75.22  ? 169 LYS A O   1 
ATOM   1132 C CB  . LYS A 1 169 ? 223.951 263.912 348.155 1.00 73.30  ? 169 LYS A CB  1 
ATOM   1133 C CG  . LYS A 1 169 ? 224.329 263.434 349.544 1.00 76.94  ? 169 LYS A CG  1 
ATOM   1134 C CD  . LYS A 1 169 ? 223.441 264.050 350.609 1.00 77.75  ? 169 LYS A CD  1 
ATOM   1135 C CE  . LYS A 1 169 ? 223.896 263.654 352.003 1.00 79.95  ? 169 LYS A CE  1 
ATOM   1136 N NZ  . LYS A 1 169 ? 223.022 264.223 353.065 1.00 79.97  ? 169 LYS A NZ  1 
ATOM   1137 N N   . TRP A 1 170 ? 221.743 265.202 346.270 1.00 75.43  ? 170 TRP A N   1 
ATOM   1138 C CA  . TRP A 1 170 ? 221.402 265.842 345.007 1.00 75.44  ? 170 TRP A CA  1 
ATOM   1139 C C   . TRP A 1 170 ? 222.627 266.177 344.167 1.00 79.31  ? 170 TRP A C   1 
ATOM   1140 O O   . TRP A 1 170 ? 222.473 266.498 342.984 1.00 76.64  ? 170 TRP A O   1 
ATOM   1141 C CB  . TRP A 1 170 ? 220.608 267.120 345.264 1.00 69.98  ? 170 TRP A CB  1 
ATOM   1142 C CG  . TRP A 1 170 ? 221.468 268.276 345.654 1.00 74.13  ? 170 TRP A CG  1 
ATOM   1143 C CD1 . TRP A 1 170 ? 221.872 268.609 346.912 1.00 73.01  ? 170 TRP A CD1 1 
ATOM   1144 C CD2 . TRP A 1 170 ? 222.036 269.257 344.778 1.00 79.34  ? 170 TRP A CD2 1 
ATOM   1145 N NE1 . TRP A 1 170 ? 222.654 269.737 346.876 1.00 76.27  ? 170 TRP A NE1 1 
ATOM   1146 C CE2 . TRP A 1 170 ? 222.769 270.155 345.576 1.00 81.13  ? 170 TRP A CE2 1 
ATOM   1147 C CE3 . TRP A 1 170 ? 221.992 269.466 343.397 1.00 74.30  ? 170 TRP A CE3 1 
ATOM   1148 C CZ2 . TRP A 1 170 ? 223.454 271.242 345.040 1.00 77.67  ? 170 TRP A CZ2 1 
ATOM   1149 C CZ3 . TRP A 1 170 ? 222.671 270.545 342.866 1.00 70.23  ? 170 TRP A CZ3 1 
ATOM   1150 C CH2 . TRP A 1 170 ? 223.393 271.419 343.686 1.00 73.65  ? 170 TRP A CH2 1 
ATOM   1151 N N   . ASP A 1 171 ? 223.825 266.125 344.743 1.00 78.54  ? 171 ASP A N   1 
ATOM   1152 C CA  . ASP A 1 171 ? 225.045 266.536 344.058 1.00 74.97  ? 171 ASP A CA  1 
ATOM   1153 C C   . ASP A 1 171 ? 226.148 265.504 344.269 1.00 78.77  ? 171 ASP A C   1 
ATOM   1154 O O   . ASP A 1 171 ? 227.287 265.838 344.595 1.00 79.55  ? 171 ASP A O   1 
ATOM   1155 C CB  . ASP A 1 171 ? 225.488 267.913 344.543 1.00 72.84  ? 171 ASP A CB  1 
ATOM   1156 C CG  . ASP A 1 171 ? 225.625 267.980 346.050 1.00 77.05  ? 171 ASP A CG  1 
ATOM   1157 O OD1 . ASP A 1 171 ? 225.330 266.967 346.718 1.00 79.30  ? 171 ASP A OD1 1 
ATOM   1158 O OD2 . ASP A 1 171 ? 226.025 269.044 346.568 1.00 75.00  ? 171 ASP A OD2 1 
ATOM   1159 N N   . ASP A 1 172 ? 225.820 264.228 344.091 1.00 76.84  ? 172 ASP A N   1 
ATOM   1160 C CA  . ASP A 1 172 ? 226.800 263.156 344.183 1.00 75.47  ? 172 ASP A CA  1 
ATOM   1161 C C   . ASP A 1 172 ? 227.102 262.607 342.794 1.00 74.03  ? 172 ASP A C   1 
ATOM   1162 O O   . ASP A 1 172 ? 226.491 262.994 341.796 1.00 70.78  ? 172 ASP A O   1 
ATOM   1163 C CB  . ASP A 1 172 ? 226.312 262.040 345.114 1.00 74.38  ? 172 ASP A CB  1 
ATOM   1164 C CG  . ASP A 1 172 ? 225.114 261.298 344.565 1.00 79.21  ? 172 ASP A CG  1 
ATOM   1165 O OD1 . ASP A 1 172 ? 224.625 261.660 343.477 1.00 81.58  ? 172 ASP A OD1 1 
ATOM   1166 O OD2 . ASP A 1 172 ? 224.659 260.342 345.227 1.00 77.99  ? 172 ASP A OD2 1 
ATOM   1167 N N   . TYR A 1 173 ? 228.064 261.684 342.745 1.00 63.67  ? 173 TYR A N   1 
ATOM   1168 C CA  . TYR A 1 173 ? 228.570 261.208 341.462 1.00 63.62  ? 173 TYR A CA  1 
ATOM   1169 C C   . TYR A 1 173 ? 227.475 260.575 340.614 1.00 67.82  ? 173 TYR A C   1 
ATOM   1170 O O   . TYR A 1 173 ? 227.507 260.681 339.382 1.00 73.85  ? 173 TYR A O   1 
ATOM   1171 C CB  . TYR A 1 173 ? 229.696 260.201 341.692 1.00 62.93  ? 173 TYR A CB  1 
ATOM   1172 C CG  . TYR A 1 173 ? 229.220 258.894 342.280 1.00 63.62  ? 173 TYR A CG  1 
ATOM   1173 C CD1 . TYR A 1 173 ? 229.052 258.746 343.649 1.00 63.51  ? 173 TYR A CD1 1 
ATOM   1174 C CD2 . TYR A 1 173 ? 228.934 257.810 341.464 1.00 63.49  ? 173 TYR A CD2 1 
ATOM   1175 C CE1 . TYR A 1 173 ? 228.615 257.555 344.188 1.00 68.73  ? 173 TYR A CE1 1 
ATOM   1176 C CE2 . TYR A 1 173 ? 228.497 256.615 341.994 1.00 65.84  ? 173 TYR A CE2 1 
ATOM   1177 C CZ  . TYR A 1 173 ? 228.338 256.493 343.356 1.00 69.10  ? 173 TYR A CZ  1 
ATOM   1178 O OH  . TYR A 1 173 ? 227.901 255.302 343.887 1.00 63.63  ? 173 TYR A OH  1 
ATOM   1179 N N   . THR A 1 174 ? 226.495 259.927 341.246 1.00 60.67  ? 174 THR A N   1 
ATOM   1180 C CA  . THR A 1 174 ? 225.526 259.133 340.500 1.00 59.01  ? 174 THR A CA  1 
ATOM   1181 C C   . THR A 1 174 ? 224.756 259.957 339.480 1.00 59.77  ? 174 THR A C   1 
ATOM   1182 O O   . THR A 1 174 ? 224.221 259.391 338.522 1.00 61.54  ? 174 THR A O   1 
ATOM   1183 C CB  . THR A 1 174 ? 224.541 258.470 341.460 1.00 60.31  ? 174 THR A CB  1 
ATOM   1184 O OG1 . THR A 1 174 ? 223.868 259.476 342.223 1.00 57.90  ? 174 THR A OG1 1 
ATOM   1185 C CG2 . THR A 1 174 ? 225.265 257.525 342.402 1.00 67.22  ? 174 THR A CG2 1 
ATOM   1186 N N   . TRP A 1 175 ? 224.689 261.272 339.656 1.00 53.33  ? 175 TRP A N   1 
ATOM   1187 C CA  . TRP A 1 175 ? 223.946 262.124 338.740 1.00 56.04  ? 175 TRP A CA  1 
ATOM   1188 C C   . TRP A 1 175 ? 224.670 262.356 337.421 1.00 57.07  ? 175 TRP A C   1 
ATOM   1189 O O   . TRP A 1 175 ? 224.121 263.036 336.548 1.00 59.88  ? 175 TRP A O   1 
ATOM   1190 C CB  . TRP A 1 175 ? 223.649 263.468 339.405 1.00 63.70  ? 175 TRP A CB  1 
ATOM   1191 C CG  . TRP A 1 175 ? 222.738 263.353 340.583 1.00 58.79  ? 175 TRP A CG  1 
ATOM   1192 C CD1 . TRP A 1 175 ? 223.068 263.520 341.893 1.00 60.88  ? 175 TRP A CD1 1 
ATOM   1193 C CD2 . TRP A 1 175 ? 221.343 263.039 340.558 1.00 59.79  ? 175 TRP A CD2 1 
ATOM   1194 N NE1 . TRP A 1 175 ? 221.965 263.333 342.687 1.00 57.98  ? 175 TRP A NE1 1 
ATOM   1195 C CE2 . TRP A 1 175 ? 220.892 263.035 341.890 1.00 58.40  ? 175 TRP A CE2 1 
ATOM   1196 C CE3 . TRP A 1 175 ? 220.430 262.762 339.537 1.00 60.46  ? 175 TRP A CE3 1 
ATOM   1197 C CZ2 . TRP A 1 175 ? 219.572 262.766 342.228 1.00 61.41  ? 175 TRP A CZ2 1 
ATOM   1198 C CZ3 . TRP A 1 175 ? 219.122 262.495 339.874 1.00 60.23  ? 175 TRP A CZ3 1 
ATOM   1199 C CH2 . TRP A 1 175 ? 218.704 262.500 341.208 1.00 61.69  ? 175 TRP A CH2 1 
ATOM   1200 N N   . GLN A 1 176 ? 225.878 261.818 337.247 1.00 49.15  ? 176 GLN A N   1 
ATOM   1201 C CA  . GLN A 1 176 ? 226.599 262.031 335.999 1.00 47.15  ? 176 GLN A CA  1 
ATOM   1202 C C   . GLN A 1 176 ? 225.916 261.368 334.811 1.00 49.83  ? 176 GLN A C   1 
ATOM   1203 O O   . GLN A 1 176 ? 226.210 261.728 333.667 1.00 57.77  ? 176 GLN A O   1 
ATOM   1204 C CB  . GLN A 1 176 ? 228.032 261.517 336.125 1.00 54.58  ? 176 GLN A CB  1 
ATOM   1205 C CG  . GLN A 1 176 ? 228.894 262.343 337.058 1.00 53.88  ? 176 GLN A CG  1 
ATOM   1206 C CD  . GLN A 1 176 ? 230.312 261.825 337.151 1.00 56.49  ? 176 GLN A CD  1 
ATOM   1207 O OE1 . GLN A 1 176 ? 230.753 261.039 336.315 1.00 60.01  ? 176 GLN A OE1 1 
ATOM   1208 N NE2 . GLN A 1 176 ? 231.034 262.261 338.174 1.00 59.47  ? 176 GLN A NE2 1 
ATOM   1209 N N   . THR A 1 177 ? 225.017 260.415 335.049 1.00 50.62  ? 177 THR A N   1 
ATOM   1210 C CA  . THR A 1 177 ? 224.263 259.762 333.977 1.00 53.72  ? 177 THR A CA  1 
ATOM   1211 C C   . THR A 1 177 ? 225.193 259.227 332.893 1.00 55.55  ? 177 THR A C   1 
ATOM   1212 O O   . THR A 1 177 ? 224.927 259.358 331.697 1.00 54.83  ? 177 THR A O   1 
ATOM   1213 C CB  . THR A 1 177 ? 223.234 260.713 333.366 1.00 53.66  ? 177 THR A CB  1 
ATOM   1214 O OG1 . THR A 1 177 ? 223.893 261.877 332.853 1.00 57.33  ? 177 THR A OG1 1 
ATOM   1215 C CG2 . THR A 1 177 ? 222.206 261.125 334.398 1.00 51.95  ? 177 THR A CG2 1 
ATOM   1216 N N   . SER A 1 178 ? 226.297 258.611 333.317 1.00 59.74  ? 178 SER A N   1 
ATOM   1217 C CA  . SER A 1 178 ? 227.233 258.048 332.351 1.00 60.12  ? 178 SER A CA  1 
ATOM   1218 C C   . SER A 1 178 ? 226.594 256.934 331.536 1.00 57.67  ? 178 SER A C   1 
ATOM   1219 O O   . SER A 1 178 ? 226.910 256.776 330.352 1.00 56.16  ? 178 SER A O   1 
ATOM   1220 C CB  . SER A 1 178 ? 228.471 257.525 333.069 1.00 56.48  ? 178 SER A CB  1 
ATOM   1221 O OG  . SER A 1 178 ? 228.112 256.557 334.038 1.00 63.49  ? 178 SER A OG  1 
ATOM   1222 N N   . SER A 1 179 ? 225.705 256.153 332.146 1.00 52.87  ? 179 SER A N   1 
ATOM   1223 C CA  . SER A 1 179 ? 225.035 255.066 331.445 1.00 52.08  ? 179 SER A CA  1 
ATOM   1224 C C   . SER A 1 179 ? 223.527 255.121 331.657 1.00 53.56  ? 179 SER A C   1 
ATOM   1225 O O   . SER A 1 179 ? 222.760 254.630 330.823 1.00 53.71  ? 179 SER A O   1 
ATOM   1226 C CB  . SER A 1 179 ? 225.586 253.723 331.913 1.00 53.97  ? 179 SER A CB  1 
ATOM   1227 O OG  . SER A 1 179 ? 226.994 253.677 331.773 1.00 59.10  ? 179 SER A OG  1 
ATOM   1228 N N   . ASN A 1 180 ? 223.094 255.704 332.762 1.00 49.37  ? 180 ASN A N   1 
ATOM   1229 C CA  . ASN A 1 180 ? 221.669 255.845 333.021 1.00 40.28  ? 180 ASN A CA  1 
ATOM   1230 C C   . ASN A 1 180 ? 221.086 256.908 332.099 1.00 50.38  ? 180 ASN A C   1 
ATOM   1231 O O   . ASN A 1 180 ? 221.549 258.054 332.130 1.00 62.30  ? 180 ASN A O   1 
ATOM   1232 C CB  . ASN A 1 180 ? 221.435 256.230 334.476 1.00 36.41  ? 180 ASN A CB  1 
ATOM   1233 C CG  . ASN A 1 180 ? 221.857 255.148 335.440 1.00 49.05  ? 180 ASN A CG  1 
ATOM   1234 O OD1 . ASN A 1 180 ? 221.579 253.970 335.228 1.00 55.74  ? 180 ASN A OD1 1 
ATOM   1235 N ND2 . ASN A 1 180 ? 222.539 255.541 336.508 1.00 55.94  ? 180 ASN A ND2 1 
ATOM   1236 N N   . PRO A 1 181 ? 220.085 256.595 331.276 1.00 48.14  ? 181 PRO A N   1 
ATOM   1237 C CA  . PRO A 1 181 ? 219.463 257.648 330.470 1.00 45.09  ? 181 PRO A CA  1 
ATOM   1238 C C   . PRO A 1 181 ? 218.843 258.710 331.361 1.00 43.78  ? 181 PRO A C   1 
ATOM   1239 O O   . PRO A 1 181 ? 218.344 258.424 332.451 1.00 55.22  ? 181 PRO A O   1 
ATOM   1240 C CB  . PRO A 1 181 ? 218.400 256.900 329.658 1.00 46.16  ? 181 PRO A CB  1 
ATOM   1241 C CG  . PRO A 1 181 ? 218.140 255.656 330.420 1.00 50.02  ? 181 PRO A CG  1 
ATOM   1242 C CD  . PRO A 1 181 ? 219.438 255.290 331.061 1.00 45.09  ? 181 PRO A CD  1 
ATOM   1243 N N   . SER A 1 182 ? 218.887 259.954 330.892 1.00 42.59  ? 182 SER A N   1 
ATOM   1244 C CA  . SER A 1 182 ? 218.377 261.065 331.675 1.00 48.08  ? 182 SER A CA  1 
ATOM   1245 C C   . SER A 1 182 ? 217.837 262.141 330.747 1.00 58.04  ? 182 SER A C   1 
ATOM   1246 O O   . SER A 1 182 ? 218.296 262.296 329.613 1.00 58.75  ? 182 SER A O   1 
ATOM   1247 C CB  . SER A 1 182 ? 219.460 261.653 332.579 1.00 49.46  ? 182 SER A CB  1 
ATOM   1248 O OG  . SER A 1 182 ? 220.574 262.074 331.814 1.00 54.50  ? 182 SER A OG  1 
ATOM   1249 N N   . ILE A 1 183 ? 216.858 262.884 331.252 1.00 62.85  ? 183 ILE A N   1 
ATOM   1250 C CA  . ILE A 1 183 ? 216.236 263.989 330.535 1.00 49.66  ? 183 ILE A CA  1 
ATOM   1251 C C   . ILE A 1 183 ? 216.460 265.263 331.332 1.00 51.45  ? 183 ILE A C   1 
ATOM   1252 O O   . ILE A 1 183 ? 216.301 265.276 332.557 1.00 59.59  ? 183 ILE A O   1 
ATOM   1253 C CB  . ILE A 1 183 ? 214.728 263.758 330.314 1.00 39.66  ? 183 ILE A CB  1 
ATOM   1254 C CG1 . ILE A 1 183 ? 214.500 262.544 329.421 1.00 41.72  ? 183 ILE A CG1 1 
ATOM   1255 C CG2 . ILE A 1 183 ? 214.091 264.993 329.700 1.00 49.13  ? 183 ILE A CG2 1 
ATOM   1256 C CD1 . ILE A 1 183 ? 213.055 262.167 329.284 1.00 48.16  ? 183 ILE A CD1 1 
ATOM   1257 N N   . PHE A 1 184 ? 216.828 266.330 330.636 1.00 44.73  ? 184 PHE A N   1 
ATOM   1258 C CA  . PHE A 1 184 ? 216.949 267.655 331.231 1.00 46.09  ? 184 PHE A CA  1 
ATOM   1259 C C   . PHE A 1 184 ? 215.803 268.506 330.703 1.00 46.43  ? 184 PHE A C   1 
ATOM   1260 O O   . PHE A 1 184 ? 215.750 268.819 329.510 1.00 50.89  ? 184 PHE A O   1 
ATOM   1261 C CB  . PHE A 1 184 ? 218.304 268.276 330.915 1.00 45.54  ? 184 PHE A CB  1 
ATOM   1262 C CG  . PHE A 1 184 ? 219.439 267.625 331.638 1.00 45.65  ? 184 PHE A CG  1 
ATOM   1263 C CD1 . PHE A 1 184 ? 220.038 266.489 331.131 1.00 47.90  ? 184 PHE A CD1 1 
ATOM   1264 C CD2 . PHE A 1 184 ? 219.898 268.140 332.834 1.00 48.74  ? 184 PHE A CD2 1 
ATOM   1265 C CE1 . PHE A 1 184 ? 221.075 265.886 331.798 1.00 44.94  ? 184 PHE A CE1 1 
ATOM   1266 C CE2 . PHE A 1 184 ? 220.936 267.540 333.504 1.00 51.15  ? 184 PHE A CE2 1 
ATOM   1267 C CZ  . PHE A 1 184 ? 221.524 266.411 332.985 1.00 47.77  ? 184 PHE A CZ  1 
ATOM   1268 N N   . TYR A 1 185 ? 214.891 268.870 331.595 1.00 43.42  ? 185 TYR A N   1 
ATOM   1269 C CA  . TYR A 1 185 ? 213.686 269.610 331.250 1.00 49.86  ? 185 TYR A CA  1 
ATOM   1270 C C   . TYR A 1 185 ? 213.829 271.034 331.765 1.00 54.54  ? 185 TYR A C   1 
ATOM   1271 O O   . TYR A 1 185 ? 214.019 271.248 332.966 1.00 53.83  ? 185 TYR A O   1 
ATOM   1272 C CB  . TYR A 1 185 ? 212.456 268.929 331.848 1.00 48.75  ? 185 TYR A CB  1 
ATOM   1273 C CG  . TYR A 1 185 ? 211.168 269.698 331.681 1.00 50.88  ? 185 TYR A CG  1 
ATOM   1274 C CD1 . TYR A 1 185 ? 210.513 269.736 330.461 1.00 47.67  ? 185 TYR A CD1 1 
ATOM   1275 C CD2 . TYR A 1 185 ? 210.598 270.373 332.749 1.00 53.00  ? 185 TYR A CD2 1 
ATOM   1276 C CE1 . TYR A 1 185 ? 209.335 270.433 330.309 1.00 51.80  ? 185 TYR A CE1 1 
ATOM   1277 C CE2 . TYR A 1 185 ? 209.421 271.072 332.604 1.00 51.24  ? 185 TYR A CE2 1 
ATOM   1278 C CZ  . TYR A 1 185 ? 208.793 271.098 331.382 1.00 53.96  ? 185 TYR A CZ  1 
ATOM   1279 O OH  . TYR A 1 185 ? 207.617 271.793 331.230 1.00 56.70  ? 185 TYR A OH  1 
ATOM   1280 N N   . THR A 1 186 ? 213.752 272.001 330.855 1.00 58.59  ? 186 THR A N   1 
ATOM   1281 C CA  . THR A 1 186 ? 213.826 273.414 331.207 1.00 52.67  ? 186 THR A CA  1 
ATOM   1282 C C   . THR A 1 186 ? 212.414 273.895 331.507 1.00 56.63  ? 186 THR A C   1 
ATOM   1283 O O   . THR A 1 186 ? 211.588 274.019 330.597 1.00 63.16  ? 186 THR A O   1 
ATOM   1284 C CB  . THR A 1 186 ? 214.452 274.224 330.076 1.00 55.51  ? 186 THR A CB  1 
ATOM   1285 O OG1 . THR A 1 186 ? 215.704 273.639 329.700 1.00 64.22  ? 186 THR A OG1 1 
ATOM   1286 C CG2 . THR A 1 186 ? 214.682 275.656 330.516 1.00 61.52  ? 186 THR A CG2 1 
ATOM   1287 N N   . TYR A 1 187 ? 212.138 274.171 332.778 1.00 54.38  ? 187 TYR A N   1 
ATOM   1288 C CA  . TYR A 1 187 ? 210.783 274.501 333.195 1.00 53.45  ? 187 TYR A CA  1 
ATOM   1289 C C   . TYR A 1 187 ? 210.225 275.641 332.356 1.00 58.36  ? 187 TYR A C   1 
ATOM   1290 O O   . TYR A 1 187 ? 210.884 276.662 332.154 1.00 64.45  ? 187 TYR A O   1 
ATOM   1291 C CB  . TYR A 1 187 ? 210.771 274.879 334.675 1.00 55.20  ? 187 TYR A CB  1 
ATOM   1292 C CG  . TYR A 1 187 ? 209.418 275.319 335.178 1.00 56.54  ? 187 TYR A CG  1 
ATOM   1293 C CD1 . TYR A 1 187 ? 208.272 274.610 334.855 1.00 58.30  ? 187 TYR A CD1 1 
ATOM   1294 C CD2 . TYR A 1 187 ? 209.288 276.438 335.986 1.00 53.50  ? 187 TYR A CD2 1 
ATOM   1295 C CE1 . TYR A 1 187 ? 207.036 275.007 335.312 1.00 54.15  ? 187 TYR A CE1 1 
ATOM   1296 C CE2 . TYR A 1 187 ? 208.056 276.841 336.449 1.00 59.19  ? 187 TYR A CE2 1 
ATOM   1297 C CZ  . TYR A 1 187 ? 206.933 276.121 336.110 1.00 58.79  ? 187 TYR A CZ  1 
ATOM   1298 O OH  . TYR A 1 187 ? 205.700 276.519 336.569 1.00 58.53  ? 187 TYR A OH  1 
ATOM   1299 N N   . GLY A 1 188 ? 209.003 275.456 331.867 1.00 52.17  ? 188 GLY A N   1 
ATOM   1300 C CA  . GLY A 1 188 ? 208.343 276.425 331.018 1.00 52.51  ? 188 GLY A CA  1 
ATOM   1301 C C   . GLY A 1 188 ? 208.264 276.030 329.562 1.00 57.16  ? 188 GLY A C   1 
ATOM   1302 O O   . GLY A 1 188 ? 207.564 276.704 328.796 1.00 63.79  ? 188 GLY A O   1 
ATOM   1303 N N   . THR A 1 189 ? 208.950 274.970 329.151 1.00 59.33  ? 189 THR A N   1 
ATOM   1304 C CA  . THR A 1 189 ? 208.903 274.491 327.781 1.00 63.44  ? 189 THR A CA  1 
ATOM   1305 C C   . THR A 1 189 ? 207.885 273.356 327.671 1.00 59.95  ? 189 THR A C   1 
ATOM   1306 O O   . THR A 1 189 ? 207.176 273.031 328.627 1.00 56.39  ? 189 THR A O   1 
ATOM   1307 C CB  . THR A 1 189 ? 210.296 274.051 327.327 1.00 66.51  ? 189 THR A CB  1 
ATOM   1308 O OG1 . THR A 1 189 ? 210.837 273.113 328.266 1.00 71.78  ? 189 THR A OG1 1 
ATOM   1309 C CG2 . THR A 1 189 ? 211.224 275.248 327.217 1.00 58.29  ? 189 THR A CG2 1 
ATOM   1310 N N   . ALA A 1 190 ? 207.807 272.745 326.495 1.00 54.91  ? 190 ALA A N   1 
ATOM   1311 C CA  . ALA A 1 190 ? 206.847 271.673 326.290 1.00 52.86  ? 190 ALA A CA  1 
ATOM   1312 C C   . ALA A 1 190 ? 207.178 270.500 327.211 1.00 54.35  ? 190 ALA A C   1 
ATOM   1313 O O   . ALA A 1 190 ? 208.357 270.194 327.421 1.00 57.88  ? 190 ALA A O   1 
ATOM   1314 C CB  . ALA A 1 190 ? 206.857 271.214 324.832 1.00 52.25  ? 190 ALA A CB  1 
ATOM   1315 N N   . PRO A 1 191 ? 206.175 269.814 327.761 1.00 43.69  ? 191 PRO A N   1 
ATOM   1316 C CA  . PRO A 1 191 ? 206.464 268.737 328.715 1.00 39.82  ? 191 PRO A CA  1 
ATOM   1317 C C   . PRO A 1 191 ? 207.360 267.672 328.105 1.00 37.69  ? 191 PRO A C   1 
ATOM   1318 O O   . PRO A 1 191 ? 207.301 267.390 326.907 1.00 39.22  ? 191 PRO A O   1 
ATOM   1319 C CB  . PRO A 1 191 ? 205.077 268.178 329.048 1.00 40.33  ? 191 PRO A CB  1 
ATOM   1320 C CG  . PRO A 1 191 ? 204.147 269.293 328.772 1.00 37.33  ? 191 PRO A CG  1 
ATOM   1321 C CD  . PRO A 1 191 ? 204.727 270.026 327.605 1.00 40.82  ? 191 PRO A CD  1 
ATOM   1322 N N   . ALA A 1 192 ? 208.208 267.086 328.946 1.00 39.66  ? 192 ALA A N   1 
ATOM   1323 C CA  . ALA A 1 192 ? 209.162 266.099 328.458 1.00 35.30  ? 192 ALA A CA  1 
ATOM   1324 C C   . ALA A 1 192 ? 208.435 264.833 328.031 1.00 41.51  ? 192 ALA A C   1 
ATOM   1325 O O   . ALA A 1 192 ? 207.359 264.518 328.533 1.00 50.84  ? 192 ALA A O   1 
ATOM   1326 C CB  . ALA A 1 192 ? 210.193 265.772 329.536 1.00 28.88  ? 192 ALA A CB  1 
ATOM   1327 N N   . ARG A 1 193 ? 209.030 264.099 327.095 1.00 39.39  ? 193 ARG A N   1 
ATOM   1328 C CA  . ARG A 1 193 ? 208.401 262.884 326.598 1.00 37.88  ? 193 ARG A CA  1 
ATOM   1329 C C   . ARG A 1 193 ? 209.463 261.948 326.049 1.00 36.85  ? 193 ARG A C   1 
ATOM   1330 O O   . ARG A 1 193 ? 210.406 262.393 325.392 1.00 45.28  ? 193 ARG A O   1 
ATOM   1331 C CB  . ARG A 1 193 ? 207.369 263.199 325.512 1.00 36.04  ? 193 ARG A CB  1 
ATOM   1332 C CG  . ARG A 1 193 ? 207.023 262.012 324.633 1.00 37.65  ? 193 ARG A CG  1 
ATOM   1333 C CD  . ARG A 1 193 ? 205.898 262.335 323.676 1.00 40.94  ? 193 ARG A CD  1 
ATOM   1334 N NE  . ARG A 1 193 ? 204.628 262.509 324.367 1.00 38.38  ? 193 ARG A NE  1 
ATOM   1335 C CZ  . ARG A 1 193 ? 203.491 262.832 323.768 1.00 46.45  ? 193 ARG A CZ  1 
ATOM   1336 N NH1 . ARG A 1 193 ? 203.428 263.022 322.460 1.00 47.17  ? 193 ARG A NH1 1 
ATOM   1337 N NH2 . ARG A 1 193 ? 202.390 262.969 324.499 1.00 47.31  ? 193 ARG A NH2 1 
ATOM   1338 N N   . ILE A 1 194 ? 209.290 260.650 326.304 1.00 44.07  ? 194 ILE A N   1 
ATOM   1339 C CA  . ILE A 1 194 ? 210.190 259.634 325.768 1.00 46.37  ? 194 ILE A CA  1 
ATOM   1340 C C   . ILE A 1 194 ? 209.454 258.307 325.670 1.00 42.14  ? 194 ILE A C   1 
ATOM   1341 O O   . ILE A 1 194 ? 208.618 257.975 326.513 1.00 43.00  ? 194 ILE A O   1 
ATOM   1342 C CB  . ILE A 1 194 ? 211.459 259.468 326.631 1.00 37.77  ? 194 ILE A CB  1 
ATOM   1343 C CG1 . ILE A 1 194 ? 211.076 259.338 328.098 1.00 34.75  ? 194 ILE A CG1 1 
ATOM   1344 C CG2 . ILE A 1 194 ? 212.403 260.631 326.423 1.00 46.33  ? 194 ILE A CG2 1 
ATOM   1345 C CD1 . ILE A 1 194 ? 212.162 258.764 328.932 1.00 41.27  ? 194 ILE A CD1 1 
ATOM   1346 N N   . SER A 1 195 ? 209.799 257.534 324.647 1.00 43.45  ? 195 SER A N   1 
ATOM   1347 C CA  . SER A 1 195 ? 209.250 256.204 324.437 1.00 44.20  ? 195 SER A CA  1 
ATOM   1348 C C   . SER A 1 195 ? 210.237 255.140 324.902 1.00 40.86  ? 195 SER A C   1 
ATOM   1349 O O   . SER A 1 195 ? 211.442 255.375 325.006 1.00 47.43  ? 195 SER A O   1 
ATOM   1350 C CB  . SER A 1 195 ? 208.908 255.986 322.962 1.00 47.56  ? 195 SER A CB  1 
ATOM   1351 O OG  . SER A 1 195 ? 207.913 256.896 322.530 1.00 47.64  ? 195 SER A OG  1 
ATOM   1352 N N   . VAL A 1 196 ? 209.701 253.957 325.182 1.00 39.68  ? 196 VAL A N   1 
ATOM   1353 C CA  . VAL A 1 196 ? 210.483 252.830 325.681 1.00 38.99  ? 196 VAL A CA  1 
ATOM   1354 C C   . VAL A 1 196 ? 209.900 251.551 325.093 1.00 42.55  ? 196 VAL A C   1 
ATOM   1355 O O   . VAL A 1 196 ? 208.671 251.417 325.017 1.00 54.91  ? 196 VAL A O   1 
ATOM   1356 C CB  . VAL A 1 196 ? 210.467 252.775 327.216 1.00 39.70  ? 196 VAL A CB  1 
ATOM   1357 C CG1 . VAL A 1 196 ? 211.432 251.721 327.715 1.00 38.57  ? 196 VAL A CG1 1 
ATOM   1358 C CG2 . VAL A 1 196 ? 210.801 254.129 327.806 1.00 37.37  ? 196 VAL A CG2 1 
ATOM   1359 N N   . PRO A 1 197 ? 210.715 250.593 324.674 1.00 38.59  ? 197 PRO A N   1 
ATOM   1360 C CA  . PRO A 1 197 ? 210.180 249.330 324.162 1.00 42.83  ? 197 PRO A CA  1 
ATOM   1361 C C   . PRO A 1 197 ? 209.714 248.445 325.312 1.00 48.96  ? 197 PRO A C   1 
ATOM   1362 O O   . PRO A 1 197 ? 209.739 248.830 326.478 1.00 51.70  ? 197 PRO A O   1 
ATOM   1363 C CB  . PRO A 1 197 ? 211.372 248.723 323.422 1.00 44.89  ? 197 PRO A CB  1 
ATOM   1364 C CG  . PRO A 1 197 ? 212.548 249.240 324.149 1.00 50.79  ? 197 PRO A CG  1 
ATOM   1365 C CD  . PRO A 1 197 ? 212.186 250.626 324.603 1.00 47.52  ? 197 PRO A CD  1 
ATOM   1366 N N   . TYR A 1 198 ? 209.274 247.242 324.958 1.00 48.99  ? 198 TYR A N   1 
ATOM   1367 C CA  . TYR A 1 198 ? 208.908 246.254 325.962 1.00 46.54  ? 198 TYR A CA  1 
ATOM   1368 C C   . TYR A 1 198 ? 210.164 245.782 326.685 1.00 46.74  ? 198 TYR A C   1 
ATOM   1369 O O   . TYR A 1 198 ? 211.051 245.179 326.072 1.00 36.86  ? 198 TYR A O   1 
ATOM   1370 C CB  . TYR A 1 198 ? 208.183 245.085 325.303 1.00 34.72  ? 198 TYR A CB  1 
ATOM   1371 C CG  . TYR A 1 198 ? 207.954 243.913 326.220 1.00 32.90  ? 198 TYR A CG  1 
ATOM   1372 C CD1 . TYR A 1 198 ? 206.932 243.928 327.152 1.00 36.60  ? 198 TYR A CD1 1 
ATOM   1373 C CD2 . TYR A 1 198 ? 208.758 242.788 326.151 1.00 37.22  ? 198 TYR A CD2 1 
ATOM   1374 C CE1 . TYR A 1 198 ? 206.722 242.861 327.992 1.00 41.29  ? 198 TYR A CE1 1 
ATOM   1375 C CE2 . TYR A 1 198 ? 208.554 241.717 326.987 1.00 41.52  ? 198 TYR A CE2 1 
ATOM   1376 C CZ  . TYR A 1 198 ? 207.535 241.758 327.904 1.00 42.26  ? 198 TYR A CZ  1 
ATOM   1377 O OH  . TYR A 1 198 ? 207.329 240.687 328.739 1.00 44.30  ? 198 TYR A OH  1 
ATOM   1378 N N   . VAL A 1 199 ? 210.244 246.057 327.986 1.00 39.87  ? 199 VAL A N   1 
ATOM   1379 C CA  . VAL A 1 199 ? 211.446 245.806 328.769 1.00 37.13  ? 199 VAL A CA  1 
ATOM   1380 C C   . VAL A 1 199 ? 211.283 244.613 329.701 1.00 44.33  ? 199 VAL A C   1 
ATOM   1381 O O   . VAL A 1 199 ? 212.132 244.392 330.569 1.00 39.35  ? 199 VAL A O   1 
ATOM   1382 C CB  . VAL A 1 199 ? 211.859 247.055 329.564 1.00 32.90  ? 199 VAL A CB  1 
ATOM   1383 C CG1 . VAL A 1 199 ? 211.821 248.284 328.678 1.00 39.98  ? 199 VAL A CG1 1 
ATOM   1384 C CG2 . VAL A 1 199 ? 210.960 247.237 330.771 1.00 36.63  ? 199 VAL A CG2 1 
ATOM   1385 N N   . GLY A 1 200 ? 210.213 243.838 329.551 1.00 43.65  ? 200 GLY A N   1 
ATOM   1386 C CA  . GLY A 1 200 ? 210.001 242.710 330.439 1.00 36.92  ? 200 GLY A CA  1 
ATOM   1387 C C   . GLY A 1 200 ? 210.994 241.593 330.168 1.00 38.24  ? 200 GLY A C   1 
ATOM   1388 O O   . GLY A 1 200 ? 211.267 241.238 329.021 1.00 33.61  ? 200 GLY A O   1 
ATOM   1389 N N   . ILE A 1 201 ? 211.545 241.037 331.249 1.00 50.14  ? 201 ILE A N   1 
ATOM   1390 C CA  . ILE A 1 201 ? 212.427 239.883 331.110 1.00 43.14  ? 201 ILE A CA  1 
ATOM   1391 C C   . ILE A 1 201 ? 211.637 238.673 330.632 1.00 43.20  ? 201 ILE A C   1 
ATOM   1392 O O   . ILE A 1 201 ? 212.108 237.901 329.789 1.00 54.60  ? 201 ILE A O   1 
ATOM   1393 C CB  . ILE A 1 201 ? 213.164 239.597 332.432 1.00 30.03  ? 201 ILE A CB  1 
ATOM   1394 C CG1 . ILE A 1 201 ? 212.177 239.369 333.575 1.00 42.94  ? 201 ILE A CG1 1 
ATOM   1395 C CG2 . ILE A 1 201 ? 214.101 240.739 332.771 1.00 39.49  ? 201 ILE A CG2 1 
ATOM   1396 C CD1 . ILE A 1 201 ? 212.845 239.167 334.914 1.00 48.81  ? 201 ILE A CD1 1 
ATOM   1397 N N   . SER A 1 202 ? 210.429 238.488 331.154 1.00 31.88  ? 202 SER A N   1 
ATOM   1398 C CA  . SER A 1 202 ? 209.539 237.460 330.645 1.00 38.47  ? 202 SER A CA  1 
ATOM   1399 C C   . SER A 1 202 ? 209.006 237.878 329.278 1.00 43.24  ? 202 SER A C   1 
ATOM   1400 O O   . SER A 1 202 ? 209.363 238.924 328.732 1.00 49.38  ? 202 SER A O   1 
ATOM   1401 C CB  . SER A 1 202 ? 208.397 237.218 331.625 1.00 47.01  ? 202 SER A CB  1 
ATOM   1402 O OG  . SER A 1 202 ? 207.626 238.392 331.802 1.00 59.25  ? 202 SER A OG  1 
ATOM   1403 N N   . ASN A 1 203 ? 208.130 237.053 328.715 1.00 44.47  ? 203 ASN A N   1 
ATOM   1404 C CA  . ASN A 1 203 ? 207.557 237.317 327.405 1.00 38.44  ? 203 ASN A CA  1 
ATOM   1405 C C   . ASN A 1 203 ? 206.284 238.150 327.475 1.00 46.98  ? 203 ASN A C   1 
ATOM   1406 O O   . ASN A 1 203 ? 205.648 238.370 326.442 1.00 57.37  ? 203 ASN A O   1 
ATOM   1407 C CB  . ASN A 1 203 ? 207.275 236.001 326.681 1.00 40.10  ? 203 ASN A CB  1 
ATOM   1408 C CG  . ASN A 1 203 ? 208.534 235.204 326.421 1.00 54.66  ? 203 ASN A CG  1 
ATOM   1409 O OD1 . ASN A 1 203 ? 209.058 235.199 325.309 1.00 61.91  ? 203 ASN A OD1 1 
ATOM   1410 N ND2 . ASN A 1 203 ? 209.033 234.534 327.451 1.00 55.07  ? 203 ASN A ND2 1 
ATOM   1411 N N   . ALA A 1 204 ? 205.890 238.600 328.664 1.00 43.63  ? 204 ALA A N   1 
ATOM   1412 C CA  . ALA A 1 204 ? 204.742 239.481 328.815 1.00 39.73  ? 204 ALA A CA  1 
ATOM   1413 C C   . ALA A 1 204 ? 204.691 239.961 330.255 1.00 33.80  ? 204 ALA A C   1 
ATOM   1414 O O   . ALA A 1 204 ? 204.999 239.199 331.173 1.00 38.68  ? 204 ALA A O   1 
ATOM   1415 C CB  . ALA A 1 204 ? 203.435 238.771 328.445 1.00 34.77  ? 204 ALA A CB  1 
ATOM   1416 N N   . TYR A 1 205 ? 204.306 241.219 330.448 1.00 33.70  ? 205 TYR A N   1 
ATOM   1417 C CA  . TYR A 1 205 ? 204.174 241.746 331.798 1.00 40.15  ? 205 TYR A CA  1 
ATOM   1418 C C   . TYR A 1 205 ? 203.151 240.930 332.572 1.00 42.35  ? 205 TYR A C   1 
ATOM   1419 O O   . TYR A 1 205 ? 202.065 240.633 332.069 1.00 42.63  ? 205 TYR A O   1 
ATOM   1420 C CB  . TYR A 1 205 ? 203.757 243.214 331.765 1.00 45.52  ? 205 TYR A CB  1 
ATOM   1421 C CG  . TYR A 1 205 ? 204.796 244.139 331.180 1.00 37.51  ? 205 TYR A CG  1 
ATOM   1422 C CD1 . TYR A 1 205 ? 206.020 244.317 331.799 1.00 40.77  ? 205 TYR A CD1 1 
ATOM   1423 C CD2 . TYR A 1 205 ? 204.545 244.845 330.016 1.00 40.51  ? 205 TYR A CD2 1 
ATOM   1424 C CE1 . TYR A 1 205 ? 206.968 245.164 331.269 1.00 45.73  ? 205 TYR A CE1 1 
ATOM   1425 C CE2 . TYR A 1 205 ? 205.485 245.694 329.481 1.00 40.59  ? 205 TYR A CE2 1 
ATOM   1426 C CZ  . TYR A 1 205 ? 206.694 245.849 330.110 1.00 39.03  ? 205 TYR A CZ  1 
ATOM   1427 O OH  . TYR A 1 205 ? 207.633 246.697 329.576 1.00 43.68  ? 205 TYR A OH  1 
ATOM   1428 N N   . SER A 1 206 ? 203.500 240.568 333.800 1.00 46.38  ? 206 SER A N   1 
ATOM   1429 C CA  . SER A 1 206 ? 202.637 239.765 334.660 1.00 43.31  ? 206 SER A CA  1 
ATOM   1430 C C   . SER A 1 206 ? 201.888 240.710 335.589 1.00 43.87  ? 206 SER A C   1 
ATOM   1431 O O   . SER A 1 206 ? 202.414 241.126 336.624 1.00 46.50  ? 206 SER A O   1 
ATOM   1432 C CB  . SER A 1 206 ? 203.454 238.744 335.443 1.00 56.99  ? 206 SER A CB  1 
ATOM   1433 O OG  . SER A 1 206 ? 204.127 237.855 334.571 1.00 65.66  ? 206 SER A OG  1 
ATOM   1434 N N   . HIS A 1 207 ? 200.654 241.051 335.217 1.00 50.88  ? 207 HIS A N   1 
ATOM   1435 C CA  . HIS A 1 207 ? 199.831 241.874 336.095 1.00 49.19  ? 207 HIS A CA  1 
ATOM   1436 C C   . HIS A 1 207 ? 199.559 241.155 337.407 1.00 46.48  ? 207 HIS A C   1 
ATOM   1437 O O   . HIS A 1 207 ? 199.503 241.784 338.469 1.00 52.79  ? 207 HIS A O   1 
ATOM   1438 C CB  . HIS A 1 207 ? 198.519 242.236 335.401 1.00 45.31  ? 207 HIS A CB  1 
ATOM   1439 C CG  . HIS A 1 207 ? 198.701 243.010 334.134 1.00 44.88  ? 207 HIS A CG  1 
ATOM   1440 N ND1 . HIS A 1 207 ? 197.670 243.240 333.250 1.00 46.50  ? 207 HIS A ND1 1 
ATOM   1441 C CD2 . HIS A 1 207 ? 199.793 243.605 333.602 1.00 47.81  ? 207 HIS A CD2 1 
ATOM   1442 C CE1 . HIS A 1 207 ? 198.120 243.943 332.227 1.00 52.02  ? 207 HIS A CE1 1 
ATOM   1443 N NE2 . HIS A 1 207 ? 199.406 244.178 332.416 1.00 45.88  ? 207 HIS A NE2 1 
ATOM   1444 N N   . PHE A 1 208 ? 199.391 239.837 337.352 1.00 45.80  ? 208 PHE A N   1 
ATOM   1445 C CA  . PHE A 1 208 ? 199.154 239.021 338.531 1.00 48.71  ? 208 PHE A CA  1 
ATOM   1446 C C   . PHE A 1 208 ? 200.158 237.881 338.567 1.00 50.84  ? 208 PHE A C   1 
ATOM   1447 O O   . PHE A 1 208 ? 200.549 237.340 337.530 1.00 59.10  ? 208 PHE A O   1 
ATOM   1448 C CB  . PHE A 1 208 ? 197.734 238.457 338.549 1.00 48.66  ? 208 PHE A CB  1 
ATOM   1449 C CG  . PHE A 1 208 ? 196.671 239.508 338.517 1.00 41.72  ? 208 PHE A CG  1 
ATOM   1450 C CD1 . PHE A 1 208 ? 196.246 240.114 339.682 1.00 42.29  ? 208 PHE A CD1 1 
ATOM   1451 C CD2 . PHE A 1 208 ? 196.098 239.892 337.322 1.00 43.86  ? 208 PHE A CD2 1 
ATOM   1452 C CE1 . PHE A 1 208 ? 195.271 241.080 339.655 1.00 48.67  ? 208 PHE A CE1 1 
ATOM   1453 C CE2 . PHE A 1 208 ? 195.123 240.859 337.289 1.00 48.90  ? 208 PHE A CE2 1 
ATOM   1454 C CZ  . PHE A 1 208 ? 194.708 241.453 338.455 1.00 52.23  ? 208 PHE A CZ  1 
ATOM   1455 N N   . TYR A 1 209 ? 200.566 237.518 339.778 1.00 49.37  ? 209 TYR A N   1 
ATOM   1456 C CA  . TYR A 1 209 ? 201.549 236.462 339.989 1.00 50.18  ? 209 TYR A CA  1 
ATOM   1457 C C   . TYR A 1 209 ? 201.128 235.690 341.229 1.00 52.62  ? 209 TYR A C   1 
ATOM   1458 O O   . TYR A 1 209 ? 201.196 236.220 342.341 1.00 55.06  ? 209 TYR A O   1 
ATOM   1459 C CB  . TYR A 1 209 ? 202.954 237.044 340.149 1.00 49.59  ? 209 TYR A CB  1 
ATOM   1460 C CG  . TYR A 1 209 ? 204.042 236.014 340.341 1.00 49.56  ? 209 TYR A CG  1 
ATOM   1461 C CD1 . TYR A 1 209 ? 204.683 235.442 339.254 1.00 51.89  ? 209 TYR A CD1 1 
ATOM   1462 C CD2 . TYR A 1 209 ? 204.435 235.623 341.611 1.00 53.94  ? 209 TYR A CD2 1 
ATOM   1463 C CE1 . TYR A 1 209 ? 205.679 234.506 339.427 1.00 54.07  ? 209 TYR A CE1 1 
ATOM   1464 C CE2 . TYR A 1 209 ? 205.429 234.687 341.793 1.00 52.41  ? 209 TYR A CE2 1 
ATOM   1465 C CZ  . TYR A 1 209 ? 206.047 234.132 340.699 1.00 52.96  ? 209 TYR A CZ  1 
ATOM   1466 O OH  . TYR A 1 209 ? 207.041 233.198 340.877 1.00 54.36  ? 209 TYR A OH  1 
ATOM   1467 N N   . ASP A 1 210 ? 200.672 234.455 341.040 1.00 58.96  ? 210 ASP A N   1 
ATOM   1468 C CA  . ASP A 1 210 ? 200.285 233.589 342.150 1.00 55.18  ? 210 ASP A CA  1 
ATOM   1469 C C   . ASP A 1 210 ? 201.483 232.718 342.496 1.00 59.38  ? 210 ASP A C   1 
ATOM   1470 O O   . ASP A 1 210 ? 201.725 231.692 341.859 1.00 65.62  ? 210 ASP A O   1 
ATOM   1471 C CB  . ASP A 1 210 ? 199.069 232.748 341.782 1.00 63.16  ? 210 ASP A CB  1 
ATOM   1472 C CG  . ASP A 1 210 ? 198.652 231.806 342.894 1.00 69.26  ? 210 ASP A CG  1 
ATOM   1473 O OD1 . ASP A 1 210 ? 199.230 231.888 343.998 1.00 70.50  ? 210 ASP A OD1 1 
ATOM   1474 O OD2 . ASP A 1 210 ? 197.745 230.980 342.665 1.00 72.42  ? 210 ASP A OD2 1 
ATOM   1475 N N   . GLY A 1 211 ? 202.232 233.125 343.508 1.00 57.11  ? 211 GLY A N   1 
ATOM   1476 C CA  . GLY A 1 211 ? 203.418 232.397 343.900 1.00 57.15  ? 211 GLY A CA  1 
ATOM   1477 C C   . GLY A 1 211 ? 204.323 233.274 344.741 1.00 55.20  ? 211 GLY A C   1 
ATOM   1478 O O   . GLY A 1 211 ? 203.916 234.318 345.247 1.00 66.54  ? 211 GLY A O   1 
ATOM   1479 N N   . PHE A 1 212 ? 205.563 232.819 344.874 1.00 44.20  ? 212 PHE A N   1 
ATOM   1480 C CA  . PHE A 1 212 ? 206.568 233.493 345.677 1.00 47.17  ? 212 PHE A CA  1 
ATOM   1481 C C   . PHE A 1 212 ? 207.872 233.554 344.898 1.00 53.93  ? 212 PHE A C   1 
ATOM   1482 O O   . PHE A 1 212 ? 208.003 232.985 343.812 1.00 60.13  ? 212 PHE A O   1 
ATOM   1483 C CB  . PHE A 1 212 ? 206.789 232.775 347.013 1.00 53.40  ? 212 PHE A CB  1 
ATOM   1484 C CG  . PHE A 1 212 ? 205.542 232.617 347.831 1.00 48.95  ? 212 PHE A CG  1 
ATOM   1485 C CD1 . PHE A 1 212 ? 204.646 231.601 347.560 1.00 51.43  ? 212 PHE A CD1 1 
ATOM   1486 C CD2 . PHE A 1 212 ? 205.272 233.478 348.877 1.00 53.50  ? 212 PHE A CD2 1 
ATOM   1487 C CE1 . PHE A 1 212 ? 203.502 231.453 348.312 1.00 52.83  ? 212 PHE A CE1 1 
ATOM   1488 C CE2 . PHE A 1 212 ? 204.130 233.333 349.633 1.00 53.60  ? 212 PHE A CE2 1 
ATOM   1489 C CZ  . PHE A 1 212 ? 203.244 232.320 349.349 1.00 53.73  ? 212 PHE A CZ  1 
ATOM   1490 N N   . SER A 1 213 ? 208.845 234.261 345.469 1.00 57.76  ? 213 SER A N   1 
ATOM   1491 C CA  . SER A 1 213 ? 210.193 234.292 344.925 1.00 57.10  ? 213 SER A CA  1 
ATOM   1492 C C   . SER A 1 213 ? 211.134 233.326 345.629 1.00 62.51  ? 213 SER A C   1 
ATOM   1493 O O   . SER A 1 213 ? 212.181 232.987 345.069 1.00 69.02  ? 213 SER A O   1 
ATOM   1494 C CB  . SER A 1 213 ? 210.767 235.709 345.013 1.00 61.72  ? 213 SER A CB  1 
ATOM   1495 O OG  . SER A 1 213 ? 210.701 236.200 346.339 1.00 68.25  ? 213 SER A OG  1 
ATOM   1496 N N   . LYS A 1 214 ? 210.787 232.880 346.834 1.00 73.74  ? 214 LYS A N   1 
ATOM   1497 C CA  . LYS A 1 214 ? 211.538 231.860 347.549 1.00 74.27  ? 214 LYS A CA  1 
ATOM   1498 C C   . LYS A 1 214 ? 210.586 230.765 348.004 1.00 78.00  ? 214 LYS A C   1 
ATOM   1499 O O   . LYS A 1 214 ? 209.412 231.018 348.285 1.00 80.90  ? 214 LYS A O   1 
ATOM   1500 C CB  . LYS A 1 214 ? 212.260 232.425 348.775 1.00 73.46  ? 214 LYS A CB  1 
ATOM   1501 C CG  . LYS A 1 214 ? 213.209 233.570 348.498 1.00 75.88  ? 214 LYS A CG  1 
ATOM   1502 C CD  . LYS A 1 214 ? 213.911 233.990 349.780 1.00 79.57  ? 214 LYS A CD  1 
ATOM   1503 C CE  . LYS A 1 214 ? 214.747 235.241 349.592 1.00 81.48  ? 214 LYS A CE  1 
ATOM   1504 N NZ  . LYS A 1 214 ? 215.437 235.639 350.850 1.00 82.48  ? 214 LYS A NZ  1 
ATOM   1505 N N   . VAL A 1 215 ? 211.105 229.548 348.078 1.00 71.73  ? 215 VAL A N   1 
ATOM   1506 C CA  . VAL A 1 215 ? 210.383 228.399 348.615 1.00 71.76  ? 215 VAL A CA  1 
ATOM   1507 C C   . VAL A 1 215 ? 210.972 228.086 349.986 1.00 72.38  ? 215 VAL A C   1 
ATOM   1508 O O   . VAL A 1 215 ? 212.160 227.751 350.076 1.00 76.43  ? 215 VAL A O   1 
ATOM   1509 C CB  . VAL A 1 215 ? 210.479 227.181 347.684 1.00 69.39  ? 215 VAL A CB  1 
ATOM   1510 C CG1 . VAL A 1 215 ? 209.923 225.946 348.370 1.00 68.08  ? 215 VAL A CG1 1 
ATOM   1511 C CG2 . VAL A 1 215 ? 209.740 227.450 346.390 1.00 69.90  ? 215 VAL A CG2 1 
ATOM   1512 N N   . PRO A 1 216 ? 210.201 228.179 351.071 1.00 76.40  ? 216 PRO A N   1 
ATOM   1513 C CA  . PRO A 1 216 ? 210.784 227.911 352.391 1.00 82.00  ? 216 PRO A CA  1 
ATOM   1514 C C   . PRO A 1 216 ? 211.155 226.448 352.553 1.00 81.68  ? 216 PRO A C   1 
ATOM   1515 O O   . PRO A 1 216 ? 210.283 225.588 352.705 1.00 77.15  ? 216 PRO A O   1 
ATOM   1516 C CB  . PRO A 1 216 ? 209.670 228.325 353.359 1.00 81.52  ? 216 PRO A CB  1 
ATOM   1517 C CG  . PRO A 1 216 ? 208.422 228.148 352.582 1.00 79.49  ? 216 PRO A CG  1 
ATOM   1518 C CD  . PRO A 1 216 ? 208.765 228.492 351.161 1.00 76.92  ? 216 PRO A CD  1 
ATOM   1519 N N   . LEU A 1 217 ? 212.451 226.160 352.530 1.00 87.95  ? 217 LEU A N   1 
ATOM   1520 C CA  . LEU A 1 217 ? 212.918 224.787 352.590 1.00 87.98  ? 217 LEU A CA  1 
ATOM   1521 C C   . LEU A 1 217 ? 212.809 224.251 354.011 1.00 89.22  ? 217 LEU A C   1 
ATOM   1522 O O   . LEU A 1 217 ? 212.900 224.996 354.991 1.00 85.97  ? 217 LEU A O   1 
ATOM   1523 C CB  . LEU A 1 217 ? 214.358 224.693 352.090 1.00 85.08  ? 217 LEU A CB  1 
ATOM   1524 C CG  . LEU A 1 217 ? 214.576 225.298 350.699 1.00 86.11  ? 217 LEU A CG  1 
ATOM   1525 C CD1 . LEU A 1 217 ? 216.026 225.171 350.271 1.00 88.94  ? 217 LEU A CD1 1 
ATOM   1526 C CD2 . LEU A 1 217 ? 213.658 224.653 349.672 1.00 83.02  ? 217 LEU A CD2 1 
ATOM   1527 N N   . LYS A 1 218 ? 212.609 222.938 354.111 1.00 97.28  ? 218 LYS A N   1 
ATOM   1528 C CA  . LYS A 1 218 ? 212.335 222.303 355.393 1.00 95.71  ? 218 LYS A CA  1 
ATOM   1529 C C   . LYS A 1 218 ? 213.535 222.312 356.330 1.00 95.92  ? 218 LYS A C   1 
ATOM   1530 O O   . LYS A 1 218 ? 213.368 222.021 357.519 1.00 95.63  ? 218 LYS A O   1 
ATOM   1531 C CB  . LYS A 1 218 ? 211.873 220.863 355.160 1.00 92.49  ? 218 LYS A CB  1 
ATOM   1532 C CG  . LYS A 1 218 ? 211.214 220.201 356.360 1.00 93.89  ? 218 LYS A CG  1 
ATOM   1533 C CD  . LYS A 1 218 ? 209.853 220.809 356.658 1.00 95.50  ? 218 LYS A CD  1 
ATOM   1534 C CE  . LYS A 1 218 ? 209.168 220.106 357.818 1.00 94.66  ? 218 LYS A CE  1 
ATOM   1535 N NZ  . LYS A 1 218 ? 209.958 220.197 359.076 1.00 95.74  ? 218 LYS A NZ  1 
ATOM   1536 N N   . ASP A 1 219 ? 214.725 222.646 355.839 1.00 101.46 ? 219 ASP A N   1 
ATOM   1537 C CA  . ASP A 1 219 ? 215.960 222.528 356.608 1.00 102.06 ? 219 ASP A CA  1 
ATOM   1538 C C   . ASP A 1 219 ? 216.720 223.847 356.613 1.00 102.23 ? 219 ASP A C   1 
ATOM   1539 O O   . ASP A 1 219 ? 217.912 223.908 356.309 1.00 101.15 ? 219 ASP A O   1 
ATOM   1540 C CB  . ASP A 1 219 ? 216.828 221.406 356.047 1.00 102.03 ? 219 ASP A CB  1 
ATOM   1541 C CG  . ASP A 1 219 ? 217.994 221.063 356.951 1.00 104.01 ? 219 ASP A CG  1 
ATOM   1542 O OD1 . ASP A 1 219 ? 218.065 221.612 358.070 1.00 104.25 ? 219 ASP A OD1 1 
ATOM   1543 O OD2 . ASP A 1 219 ? 218.841 220.243 356.541 1.00 105.25 ? 219 ASP A OD2 1 
ATOM   1544 N N   . GLN A 1 220 ? 216.030 224.934 356.952 1.00 98.12  ? 220 GLN A N   1 
ATOM   1545 C CA  . GLN A 1 220 ? 216.683 226.225 357.109 1.00 96.73  ? 220 GLN A CA  1 
ATOM   1546 C C   . GLN A 1 220 ? 215.832 227.100 358.018 1.00 98.96  ? 220 GLN A C   1 
ATOM   1547 O O   . GLN A 1 220 ? 214.685 226.777 358.335 1.00 98.37  ? 220 GLN A O   1 
ATOM   1548 C CB  . GLN A 1 220 ? 216.927 226.904 355.756 1.00 97.23  ? 220 GLN A CB  1 
ATOM   1549 C CG  . GLN A 1 220 ? 215.675 227.404 355.055 1.00 99.44  ? 220 GLN A CG  1 
ATOM   1550 C CD  . GLN A 1 220 ? 215.976 227.990 353.690 1.00 97.76  ? 220 GLN A CD  1 
ATOM   1551 O OE1 . GLN A 1 220 ? 217.076 227.827 353.161 1.00 93.42  ? 220 GLN A OE1 1 
ATOM   1552 N NE2 . GLN A 1 220 ? 215.001 228.681 353.113 1.00 96.95  ? 220 GLN A NE2 1 
ATOM   1553 N N   . SER A 1 221 ? 216.414 228.220 358.439 1.00 105.59 ? 221 SER A N   1 
ATOM   1554 C CA  . SER A 1 221 ? 215.723 229.133 359.337 1.00 105.97 ? 221 SER A CA  1 
ATOM   1555 C C   . SER A 1 221 ? 214.447 229.661 358.691 1.00 105.94 ? 221 SER A C   1 
ATOM   1556 O O   . SER A 1 221 ? 214.366 229.842 357.473 1.00 104.02 ? 221 SER A O   1 
ATOM   1557 C CB  . SER A 1 221 ? 216.638 230.296 359.719 1.00 103.47 ? 221 SER A CB  1 
ATOM   1558 O OG  . SER A 1 221 ? 217.082 230.992 358.568 1.00 102.36 ? 221 SER A OG  1 
ATOM   1559 N N   . ALA A 1 222 ? 213.438 229.908 359.528 1.00 104.32 ? 222 ALA A N   1 
ATOM   1560 C CA  . ALA A 1 222 ? 212.149 230.363 359.020 1.00 102.72 ? 222 ALA A CA  1 
ATOM   1561 C C   . ALA A 1 222 ? 212.280 231.694 358.291 1.00 103.44 ? 222 ALA A C   1 
ATOM   1562 O O   . ALA A 1 222 ? 211.669 231.893 357.235 1.00 103.32 ? 222 ALA A O   1 
ATOM   1563 C CB  . ALA A 1 222 ? 211.145 230.478 360.166 1.00 101.20 ? 222 ALA A CB  1 
ATOM   1564 N N   . ALA A 1 223 ? 213.067 232.621 358.841 1.00 104.35 ? 223 ALA A N   1 
ATOM   1565 C CA  . ALA A 1 223 ? 213.228 233.925 358.207 1.00 105.13 ? 223 ALA A CA  1 
ATOM   1566 C C   . ALA A 1 223 ? 213.699 233.776 356.767 1.00 104.97 ? 223 ALA A C   1 
ATOM   1567 O O   . ALA A 1 223 ? 213.146 234.394 355.851 1.00 102.99 ? 223 ALA A O   1 
ATOM   1568 C CB  . ALA A 1 223 ? 214.211 234.779 359.009 1.00 102.28 ? 223 ALA A CB  1 
ATOM   1569 N N   . LEU A 1 224 ? 214.725 232.958 356.548 1.00 99.63  ? 224 LEU A N   1 
ATOM   1570 C CA  . LEU A 1 224 ? 215.172 232.682 355.191 1.00 99.30  ? 224 LEU A CA  1 
ATOM   1571 C C   . LEU A 1 224 ? 214.071 231.974 354.413 1.00 98.98  ? 224 LEU A C   1 
ATOM   1572 O O   . LEU A 1 224 ? 213.428 231.049 354.914 1.00 96.70  ? 224 LEU A O   1 
ATOM   1573 C CB  . LEU A 1 224 ? 216.439 231.830 355.212 1.00 97.06  ? 224 LEU A CB  1 
ATOM   1574 C CG  . LEU A 1 224 ? 217.749 232.605 355.360 1.00 96.44  ? 224 LEU A CG  1 
ATOM   1575 C CD1 . LEU A 1 224 ? 217.702 233.531 356.565 1.00 95.92  ? 224 LEU A CD1 1 
ATOM   1576 C CD2 . LEU A 1 224 ? 218.922 231.645 355.463 1.00 95.75  ? 224 LEU A CD2 1 
ATOM   1577 N N   . GLY A 1 225 ? 213.854 232.420 353.178 1.00 92.60  ? 225 GLY A N   1 
ATOM   1578 C CA  . GLY A 1 225 ? 212.797 231.892 352.347 1.00 94.60  ? 225 GLY A CA  1 
ATOM   1579 C C   . GLY A 1 225 ? 211.454 232.563 352.531 1.00 92.30  ? 225 GLY A C   1 
ATOM   1580 O O   . GLY A 1 225 ? 210.521 232.262 351.776 1.00 90.69  ? 225 GLY A O   1 
ATOM   1581 N N   . ASP A 1 226 ? 211.324 233.460 353.503 1.00 87.83  ? 226 ASP A N   1 
ATOM   1582 C CA  . ASP A 1 226 ? 210.073 234.171 353.738 1.00 88.79  ? 226 ASP A CA  1 
ATOM   1583 C C   . ASP A 1 226 ? 209.989 235.342 352.768 1.00 89.99  ? 226 ASP A C   1 
ATOM   1584 O O   . ASP A 1 226 ? 210.751 236.307 352.880 1.00 89.38  ? 226 ASP A O   1 
ATOM   1585 C CB  . ASP A 1 226 ? 210.000 234.648 355.185 1.00 89.95  ? 226 ASP A CB  1 
ATOM   1586 C CG  . ASP A 1 226 ? 208.639 235.202 355.552 1.00 90.70  ? 226 ASP A CG  1 
ATOM   1587 O OD1 . ASP A 1 226 ? 207.907 235.648 354.644 1.00 90.71  ? 226 ASP A OD1 1 
ATOM   1588 O OD2 . ASP A 1 226 ? 208.300 235.191 356.754 1.00 88.27  ? 226 ASP A OD2 1 
ATOM   1589 N N   . SER A 1 227 ? 209.062 235.262 351.815 1.00 80.96  ? 227 SER A N   1 
ATOM   1590 C CA  . SER A 1 227 ? 208.873 236.304 350.819 1.00 79.73  ? 227 SER A CA  1 
ATOM   1591 C C   . SER A 1 227 ? 207.393 236.633 350.701 1.00 75.54  ? 227 SER A C   1 
ATOM   1592 O O   . SER A 1 227 ? 206.530 235.793 350.967 1.00 73.10  ? 227 SER A O   1 
ATOM   1593 C CB  . SER A 1 227 ? 209.423 235.882 349.453 1.00 77.52  ? 227 SER A CB  1 
ATOM   1594 O OG  . SER A 1 227 ? 208.771 234.717 348.984 1.00 82.14  ? 227 SER A OG  1 
ATOM   1595 N N   . LEU A 1 228 ? 207.111 237.868 350.299 1.00 63.77  ? 228 LEU A N   1 
ATOM   1596 C CA  . LEU A 1 228 ? 205.734 238.329 350.206 1.00 60.39  ? 228 LEU A CA  1 
ATOM   1597 C C   . LEU A 1 228 ? 204.988 237.576 349.113 1.00 57.50  ? 228 LEU A C   1 
ATOM   1598 O O   . LEU A 1 228 ? 205.532 237.300 348.040 1.00 50.78  ? 228 LEU A O   1 
ATOM   1599 C CB  . LEU A 1 228 ? 205.698 239.830 349.927 1.00 61.70  ? 228 LEU A CB  1 
ATOM   1600 C CG  . LEU A 1 228 ? 206.389 240.709 350.971 1.00 59.13  ? 228 LEU A CG  1 
ATOM   1601 C CD1 . LEU A 1 228 ? 206.279 242.176 350.592 1.00 59.87  ? 228 LEU A CD1 1 
ATOM   1602 C CD2 . LEU A 1 228 ? 205.802 240.467 352.350 1.00 60.46  ? 228 LEU A CD2 1 
ATOM   1603 N N   . TYR A 1 229 ? 203.731 237.247 349.393 1.00 61.24  ? 229 TYR A N   1 
ATOM   1604 C CA  . TYR A 1 229 ? 202.926 236.496 348.442 1.00 60.00  ? 229 TYR A CA  1 
ATOM   1605 C C   . TYR A 1 229 ? 202.717 237.298 347.166 1.00 56.54  ? 229 TYR A C   1 
ATOM   1606 O O   . TYR A 1 229 ? 202.512 238.513 347.200 1.00 59.71  ? 229 TYR A O   1 
ATOM   1607 C CB  . TYR A 1 229 ? 201.577 236.135 349.060 1.00 58.71  ? 229 TYR A CB  1 
ATOM   1608 C CG  . TYR A 1 229 ? 200.588 235.575 348.066 1.00 58.24  ? 229 TYR A CG  1 
ATOM   1609 C CD1 . TYR A 1 229 ? 200.649 234.249 347.670 1.00 56.83  ? 229 TYR A CD1 1 
ATOM   1610 C CD2 . TYR A 1 229 ? 199.593 236.374 347.524 1.00 60.87  ? 229 TYR A CD2 1 
ATOM   1611 C CE1 . TYR A 1 229 ? 199.750 233.736 346.761 1.00 57.91  ? 229 TYR A CE1 1 
ATOM   1612 C CE2 . TYR A 1 229 ? 198.689 235.868 346.615 1.00 59.68  ? 229 TYR A CE2 1 
ATOM   1613 C CZ  . TYR A 1 229 ? 198.773 234.550 346.239 1.00 57.60  ? 229 TYR A CZ  1 
ATOM   1614 O OH  . TYR A 1 229 ? 197.874 234.042 345.334 1.00 61.87  ? 229 TYR A OH  1 
ATOM   1615 N N   . GLY A 1 230 ? 202.771 236.606 346.033 1.00 50.89  ? 230 GLY A N   1 
ATOM   1616 C CA  . GLY A 1 230 ? 202.538 237.252 344.755 1.00 47.44  ? 230 GLY A CA  1 
ATOM   1617 C C   . GLY A 1 230 ? 203.497 238.377 344.452 1.00 48.80  ? 230 GLY A C   1 
ATOM   1618 O O   . GLY A 1 230 ? 203.163 239.278 343.677 1.00 49.64  ? 230 GLY A O   1 
ATOM   1619 N N   . ALA A 1 231 ? 204.685 238.352 345.045 1.00 60.86  ? 231 ALA A N   1 
ATOM   1620 C CA  . ALA A 1 231 ? 205.723 239.339 344.782 1.00 61.49  ? 231 ALA A CA  1 
ATOM   1621 C C   . ALA A 1 231 ? 206.865 238.651 344.050 1.00 64.79  ? 231 ALA A C   1 
ATOM   1622 O O   . ALA A 1 231 ? 207.435 237.680 344.557 1.00 69.66  ? 231 ALA A O   1 
ATOM   1623 C CB  . ALA A 1 231 ? 206.221 239.974 346.080 1.00 59.16  ? 231 ALA A CB  1 
ATOM   1624 N N   . ALA A 1 232 ? 207.193 239.155 342.865 1.00 64.54  ? 232 ALA A N   1 
ATOM   1625 C CA  . ALA A 1 232 ? 208.301 238.635 342.081 1.00 65.28  ? 232 ALA A CA  1 
ATOM   1626 C C   . ALA A 1 232 ? 208.987 239.797 341.381 1.00 66.44  ? 232 ALA A C   1 
ATOM   1627 O O   . ALA A 1 232 ? 208.414 240.877 341.224 1.00 66.66  ? 232 ALA A O   1 
ATOM   1628 C CB  . ALA A 1 232 ? 207.835 237.594 341.059 1.00 62.63  ? 232 ALA A CB  1 
ATOM   1629 N N   . SER A 1 233 ? 210.228 239.566 340.964 1.00 64.73  ? 233 SER A N   1 
ATOM   1630 C CA  . SER A 1 233 ? 211.007 240.596 340.291 1.00 64.50  ? 233 SER A CA  1 
ATOM   1631 C C   . SER A 1 233 ? 210.643 240.744 338.822 1.00 64.89  ? 233 SER A C   1 
ATOM   1632 O O   . SER A 1 233 ? 211.377 241.407 338.082 1.00 60.52  ? 233 SER A O   1 
ATOM   1633 C CB  . SER A 1 233 ? 212.498 240.296 340.421 1.00 60.75  ? 233 SER A CB  1 
ATOM   1634 O OG  . SER A 1 233 ? 212.837 239.108 339.732 1.00 68.22  ? 233 SER A OG  1 
ATOM   1635 N N   . LEU A 1 234 ? 209.537 240.144 338.381 1.00 63.05  ? 234 LEU A N   1 
ATOM   1636 C CA  . LEU A 1 234 ? 209.070 240.379 337.020 1.00 61.84  ? 234 LEU A CA  1 
ATOM   1637 C C   . LEU A 1 234 ? 208.717 241.845 336.817 1.00 66.07  ? 234 LEU A C   1 
ATOM   1638 O O   . LEU A 1 234 ? 208.947 242.404 335.739 1.00 68.03  ? 234 LEU A O   1 
ATOM   1639 C CB  . LEU A 1 234 ? 207.865 239.491 336.720 1.00 56.23  ? 234 LEU A CB  1 
ATOM   1640 C CG  . LEU A 1 234 ? 208.128 237.988 336.759 1.00 60.28  ? 234 LEU A CG  1 
ATOM   1641 C CD1 . LEU A 1 234 ? 206.833 237.225 336.573 1.00 62.63  ? 234 LEU A CD1 1 
ATOM   1642 C CD2 . LEU A 1 234 ? 209.138 237.596 335.695 1.00 56.95  ? 234 LEU A CD2 1 
ATOM   1643 N N   . ASN A 1 235 ? 208.155 242.483 337.843 1.00 62.91  ? 235 ASN A N   1 
ATOM   1644 C CA  . ASN A 1 235 ? 207.820 243.900 337.807 1.00 59.36  ? 235 ASN A CA  1 
ATOM   1645 C C   . ASN A 1 235 ? 208.921 244.763 338.414 1.00 63.94  ? 235 ASN A C   1 
ATOM   1646 O O   . ASN A 1 235 ? 208.641 245.835 338.961 1.00 62.84  ? 235 ASN A O   1 
ATOM   1647 C CB  . ASN A 1 235 ? 206.495 244.145 338.526 1.00 66.08  ? 235 ASN A CB  1 
ATOM   1648 C CG  . ASN A 1 235 ? 206.561 243.809 340.001 1.00 70.07  ? 235 ASN A CG  1 
ATOM   1649 O OD1 . ASN A 1 235 ? 207.525 243.205 340.469 1.00 69.19  ? 235 ASN A OD1 1 
ATOM   1650 N ND2 . ASN A 1 235 ? 205.529 244.195 340.744 1.00 64.47  ? 235 ASN A ND2 1 
ATOM   1651 N N   . ASP A 1 236 ? 210.171 244.311 338.330 1.00 65.96  ? 236 ASP A N   1 
ATOM   1652 C CA  . ASP A 1 236 ? 211.321 245.032 338.872 1.00 65.47  ? 236 ASP A CA  1 
ATOM   1653 C C   . ASP A 1 236 ? 211.919 245.861 337.741 1.00 64.80  ? 236 ASP A C   1 
ATOM   1654 O O   . ASP A 1 236 ? 212.675 245.347 336.913 1.00 58.37  ? 236 ASP A O   1 
ATOM   1655 C CB  . ASP A 1 236 ? 212.337 244.057 339.456 1.00 63.47  ? 236 ASP A CB  1 
ATOM   1656 C CG  . ASP A 1 236 ? 213.459 244.754 340.196 1.00 66.44  ? 236 ASP A CG  1 
ATOM   1657 O OD1 . ASP A 1 236 ? 213.508 246.001 340.171 1.00 71.43  ? 236 ASP A OD1 1 
ATOM   1658 O OD2 . ASP A 1 236 ? 214.291 244.054 340.810 1.00 62.74  ? 236 ASP A OD2 1 
ATOM   1659 N N   . PHE A 1 237 ? 211.577 247.151 337.710 1.00 56.88  ? 237 PHE A N   1 
ATOM   1660 C CA  . PHE A 1 237 ? 211.983 248.039 336.628 1.00 47.27  ? 237 PHE A CA  1 
ATOM   1661 C C   . PHE A 1 237 ? 212.910 249.156 337.090 1.00 51.26  ? 237 PHE A C   1 
ATOM   1662 O O   . PHE A 1 237 ? 213.209 250.059 336.301 1.00 57.13  ? 237 PHE A O   1 
ATOM   1663 C CB  . PHE A 1 237 ? 210.751 248.646 335.955 1.00 43.59  ? 237 PHE A CB  1 
ATOM   1664 C CG  . PHE A 1 237 ? 209.762 247.627 335.476 1.00 54.42  ? 237 PHE A CG  1 
ATOM   1665 C CD1 . PHE A 1 237 ? 210.076 246.771 334.435 1.00 54.78  ? 237 PHE A CD1 1 
ATOM   1666 C CD2 . PHE A 1 237 ? 208.513 247.528 336.061 1.00 56.59  ? 237 PHE A CD2 1 
ATOM   1667 C CE1 . PHE A 1 237 ? 209.166 245.836 333.991 1.00 52.05  ? 237 PHE A CE1 1 
ATOM   1668 C CE2 . PHE A 1 237 ? 207.600 246.595 335.620 1.00 56.27  ? 237 PHE A CE2 1 
ATOM   1669 C CZ  . PHE A 1 237 ? 207.927 245.748 334.584 1.00 56.18  ? 237 PHE A CZ  1 
ATOM   1670 N N   . GLY A 1 238 ? 213.374 249.125 338.332 1.00 49.80  ? 238 GLY A N   1 
ATOM   1671 C CA  . GLY A 1 238 ? 214.240 250.171 338.823 1.00 49.24  ? 238 GLY A CA  1 
ATOM   1672 C C   . GLY A 1 238 ? 213.459 251.393 339.263 1.00 50.30  ? 238 GLY A C   1 
ATOM   1673 O O   . GLY A 1 238 ? 212.228 251.399 339.317 1.00 64.33  ? 238 GLY A O   1 
ATOM   1674 N N   . ILE A 1 239 ? 214.199 252.450 339.582 1.00 46.17  ? 239 ILE A N   1 
ATOM   1675 C CA  . ILE A 1 239 ? 213.614 253.668 340.116 1.00 45.56  ? 239 ILE A CA  1 
ATOM   1676 C C   . ILE A 1 239 ? 213.787 254.804 339.112 1.00 50.34  ? 239 ILE A C   1 
ATOM   1677 O O   . ILE A 1 239 ? 214.478 254.681 338.099 1.00 56.15  ? 239 ILE A O   1 
ATOM   1678 C CB  . ILE A 1 239 ? 214.214 254.048 341.485 1.00 47.57  ? 239 ILE A CB  1 
ATOM   1679 C CG1 . ILE A 1 239 ? 215.682 254.453 341.347 1.00 51.01  ? 239 ILE A CG1 1 
ATOM   1680 C CG2 . ILE A 1 239 ? 214.095 252.885 342.449 1.00 53.34  ? 239 ILE A CG2 1 
ATOM   1681 C CD1 . ILE A 1 239 ? 216.240 255.153 342.560 1.00 55.70  ? 239 ILE A CD1 1 
ATOM   1682 N N   . LEU A 1 240 ? 213.154 255.930 339.422 1.00 58.96  ? 240 LEU A N   1 
ATOM   1683 C CA  . LEU A 1 240 ? 213.247 257.150 338.636 1.00 52.73  ? 240 LEU A CA  1 
ATOM   1684 C C   . LEU A 1 240 ? 213.535 258.284 339.606 1.00 51.81  ? 240 LEU A C   1 
ATOM   1685 O O   . LEU A 1 240 ? 212.749 258.525 340.529 1.00 49.33  ? 240 LEU A O   1 
ATOM   1686 C CB  . LEU A 1 240 ? 211.948 257.382 337.858 1.00 42.11  ? 240 LEU A CB  1 
ATOM   1687 C CG  . LEU A 1 240 ? 211.877 258.521 336.846 1.00 52.12  ? 240 LEU A CG  1 
ATOM   1688 C CD1 . LEU A 1 240 ? 210.939 258.148 335.717 1.00 48.90  ? 240 LEU A CD1 1 
ATOM   1689 C CD2 . LEU A 1 240 ? 211.407 259.792 337.519 1.00 57.45  ? 240 LEU A CD2 1 
ATOM   1690 N N   . ALA A 1 241 ? 214.672 258.951 339.424 1.00 46.03  ? 241 ALA A N   1 
ATOM   1691 C CA  . ALA A 1 241 ? 215.153 259.971 340.346 1.00 53.22  ? 241 ALA A CA  1 
ATOM   1692 C C   . ALA A 1 241 ? 215.080 261.329 339.666 1.00 59.63  ? 241 ALA A C   1 
ATOM   1693 O O   . ALA A 1 241 ? 215.651 261.519 338.589 1.00 57.67  ? 241 ALA A O   1 
ATOM   1694 C CB  . ALA A 1 241 ? 216.584 259.673 340.791 1.00 53.20  ? 241 ALA A CB  1 
ATOM   1695 N N   . VAL A 1 242 ? 214.395 262.271 340.301 1.00 55.29  ? 242 VAL A N   1 
ATOM   1696 C CA  . VAL A 1 242 ? 214.188 263.605 339.757 1.00 47.39  ? 242 VAL A CA  1 
ATOM   1697 C C   . VAL A 1 242 ? 214.777 264.612 340.730 1.00 59.49  ? 242 VAL A C   1 
ATOM   1698 O O   . VAL A 1 242 ? 214.534 264.530 341.940 1.00 60.13  ? 242 VAL A O   1 
ATOM   1699 C CB  . VAL A 1 242 ? 212.698 263.889 339.508 1.00 50.59  ? 242 VAL A CB  1 
ATOM   1700 C CG1 . VAL A 1 242 ? 212.522 265.233 338.832 1.00 60.42  ? 242 VAL A CG1 1 
ATOM   1701 C CG2 . VAL A 1 242 ? 212.098 262.788 338.668 1.00 56.87  ? 242 VAL A CG2 1 
ATOM   1702 N N   . ARG A 1 243 ? 215.555 265.554 340.200 1.00 60.72  ? 243 ARG A N   1 
ATOM   1703 C CA  . ARG A 1 243 ? 216.179 266.583 341.019 1.00 53.50  ? 243 ARG A CA  1 
ATOM   1704 C C   . ARG A 1 243 ? 216.145 267.915 340.286 1.00 54.28  ? 243 ARG A C   1 
ATOM   1705 O O   . ARG A 1 243 ? 215.971 267.975 339.068 1.00 57.73  ? 243 ARG A O   1 
ATOM   1706 C CB  . ARG A 1 243 ? 217.627 266.230 341.379 1.00 54.87  ? 243 ARG A CB  1 
ATOM   1707 C CG  . ARG A 1 243 ? 218.579 266.166 340.197 1.00 54.59  ? 243 ARG A CG  1 
ATOM   1708 C CD  . ARG A 1 243 ? 219.956 266.661 340.590 1.00 61.68  ? 243 ARG A CD  1 
ATOM   1709 N NE  . ARG A 1 243 ? 220.891 266.635 339.472 1.00 57.17  ? 243 ARG A NE  1 
ATOM   1710 C CZ  . ARG A 1 243 ? 222.159 267.008 339.551 1.00 53.30  ? 243 ARG A CZ  1 
ATOM   1711 N NH1 . ARG A 1 243 ? 222.680 267.454 340.682 1.00 55.98  ? 243 ARG A NH1 1 
ATOM   1712 N NH2 . ARG A 1 243 ? 222.926 266.932 338.468 1.00 55.85  ? 243 ARG A NH2 1 
ATOM   1713 N N   . VAL A 1 244 ? 216.314 268.987 341.053 1.00 61.29  ? 244 VAL A N   1 
ATOM   1714 C CA  . VAL A 1 244 ? 216.416 270.339 340.519 1.00 62.80  ? 244 VAL A CA  1 
ATOM   1715 C C   . VAL A 1 244 ? 217.898 270.649 340.368 1.00 67.30  ? 244 VAL A C   1 
ATOM   1716 O O   . VAL A 1 244 ? 218.625 270.753 341.361 1.00 67.26  ? 244 VAL A O   1 
ATOM   1717 C CB  . VAL A 1 244 ? 215.722 271.360 341.428 1.00 67.31  ? 244 VAL A CB  1 
ATOM   1718 C CG1 . VAL A 1 244 ? 215.602 272.700 340.725 1.00 68.92  ? 244 VAL A CG1 1 
ATOM   1719 C CG2 . VAL A 1 244 ? 214.360 270.845 341.854 1.00 70.06  ? 244 VAL A CG2 1 
ATOM   1720 N N   . VAL A 1 245 ? 218.351 270.805 339.124 1.00 66.28  ? 245 VAL A N   1 
ATOM   1721 C CA  . VAL A 1 245 ? 219.779 270.965 338.874 1.00 58.03  ? 245 VAL A CA  1 
ATOM   1722 C C   . VAL A 1 245 ? 220.287 272.262 339.489 1.00 62.07  ? 245 VAL A C   1 
ATOM   1723 O O   . VAL A 1 245 ? 221.411 272.325 339.999 1.00 68.47  ? 245 VAL A O   1 
ATOM   1724 C CB  . VAL A 1 245 ? 220.066 270.901 337.364 1.00 56.35  ? 245 VAL A CB  1 
ATOM   1725 C CG1 . VAL A 1 245 ? 221.551 271.049 337.101 1.00 60.90  ? 245 VAL A CG1 1 
ATOM   1726 C CG2 . VAL A 1 245 ? 219.556 269.597 336.786 1.00 59.97  ? 245 VAL A CG2 1 
ATOM   1727 N N   . ASN A 1 246 ? 219.473 273.315 339.452 1.00 73.54  ? 246 ASN A N   1 
ATOM   1728 C CA  . ASN A 1 246 ? 219.902 274.608 339.967 1.00 72.62  ? 246 ASN A CA  1 
ATOM   1729 C C   . ASN A 1 246 ? 220.317 274.500 341.427 1.00 77.33  ? 246 ASN A C   1 
ATOM   1730 O O   . ASN A 1 246 ? 219.612 273.901 342.243 1.00 83.16  ? 246 ASN A O   1 
ATOM   1731 C CB  . ASN A 1 246 ? 218.779 275.633 339.825 1.00 73.66  ? 246 ASN A CB  1 
ATOM   1732 C CG  . ASN A 1 246 ? 218.452 275.945 338.385 1.00 77.24  ? 246 ASN A CG  1 
ATOM   1733 O OD1 . ASN A 1 246 ? 218.540 275.080 337.516 1.00 79.73  ? 246 ASN A OD1 1 
ATOM   1734 N ND2 . ASN A 1 246 ? 218.080 277.189 338.120 1.00 81.99  ? 246 ASN A ND2 1 
ATOM   1735 N N   . ASP A 1 247 ? 221.464 275.086 341.755 1.00 74.20  ? 247 ASP A N   1 
ATOM   1736 C CA  . ASP A 1 247 ? 221.860 275.199 343.146 1.00 72.60  ? 247 ASP A CA  1 
ATOM   1737 C C   . ASP A 1 247 ? 220.901 276.141 343.874 1.00 73.35  ? 247 ASP A C   1 
ATOM   1738 O O   . ASP A 1 247 ? 220.286 277.011 343.254 1.00 73.66  ? 247 ASP A O   1 
ATOM   1739 C CB  . ASP A 1 247 ? 223.296 275.705 343.258 1.00 76.83  ? 247 ASP A CB  1 
ATOM   1740 C CG  . ASP A 1 247 ? 223.578 276.873 342.341 1.00 82.97  ? 247 ASP A CG  1 
ATOM   1741 O OD1 . ASP A 1 247 ? 222.940 276.952 341.271 1.00 87.49  ? 247 ASP A OD1 1 
ATOM   1742 O OD2 . ASP A 1 247 ? 224.441 277.708 342.686 1.00 78.20  ? 247 ASP A OD2 1 
ATOM   1743 N N   . PRO A 1 248 ? 220.753 275.987 345.190 1.00 84.83  ? 248 PRO A N   1 
ATOM   1744 C CA  . PRO A 1 248 ? 219.641 276.648 345.883 1.00 86.35  ? 248 PRO A CA  1 
ATOM   1745 C C   . PRO A 1 248 ? 219.664 278.161 345.727 1.00 91.24  ? 248 PRO A C   1 
ATOM   1746 O O   . PRO A 1 248 ? 220.721 278.794 345.685 1.00 96.21  ? 248 PRO A O   1 
ATOM   1747 C CB  . PRO A 1 248 ? 219.839 276.234 347.346 1.00 88.03  ? 248 PRO A CB  1 
ATOM   1748 C CG  . PRO A 1 248 ? 221.265 275.837 347.448 1.00 85.81  ? 248 PRO A CG  1 
ATOM   1749 C CD  . PRO A 1 248 ? 221.609 275.238 346.124 1.00 86.43  ? 248 PRO A CD  1 
ATOM   1750 N N   . ASN A 1 249 ? 218.465 278.734 345.636 1.00 86.95  ? 249 ASN A N   1 
ATOM   1751 C CA  . ASN A 1 249 ? 218.249 280.174 345.582 1.00 85.80  ? 249 ASN A CA  1 
ATOM   1752 C C   . ASN A 1 249 ? 218.133 280.715 347.000 1.00 88.23  ? 249 ASN A C   1 
ATOM   1753 O O   . ASN A 1 249 ? 218.271 279.952 347.963 1.00 86.50  ? 249 ASN A O   1 
ATOM   1754 C CB  . ASN A 1 249 ? 216.983 280.493 344.784 1.00 85.12  ? 249 ASN A CB  1 
ATOM   1755 C CG  . ASN A 1 249 ? 217.139 280.216 343.307 1.00 86.81  ? 249 ASN A CG  1 
ATOM   1756 O OD1 . ASN A 1 249 ? 218.098 280.660 342.680 1.00 86.39  ? 249 ASN A OD1 1 
ATOM   1757 N ND2 . ASN A 1 249 ? 216.195 279.476 342.741 1.00 89.66  ? 249 ASN A ND2 1 
ATOM   1758 N N   . PRO A 1 250 ? 217.924 282.023 347.181 1.00 92.83  ? 250 PRO A N   1 
ATOM   1759 C CA  . PRO A 1 250 ? 217.568 282.530 348.514 1.00 92.48  ? 250 PRO A CA  1 
ATOM   1760 C C   . PRO A 1 250 ? 216.125 282.259 348.908 1.00 93.39  ? 250 PRO A C   1 
ATOM   1761 O O   . PRO A 1 250 ? 215.776 282.462 350.079 1.00 93.42  ? 250 PRO A O   1 
ATOM   1762 C CB  . PRO A 1 250 ? 217.827 284.041 348.398 1.00 90.76  ? 250 PRO A CB  1 
ATOM   1763 C CG  . PRO A 1 250 ? 218.664 284.213 347.174 1.00 91.95  ? 250 PRO A CG  1 
ATOM   1764 C CD  . PRO A 1 250 ? 218.255 283.115 346.254 1.00 91.94  ? 250 PRO A CD  1 
ATOM   1765 N N   . THR A 1 251 ? 215.282 281.816 347.977 1.00 95.88  ? 251 THR A N   1 
ATOM   1766 C CA  . THR A 1 251 ? 213.871 281.561 348.238 1.00 95.16  ? 251 THR A CA  1 
ATOM   1767 C C   . THR A 1 251 ? 213.536 280.135 347.830 1.00 93.69  ? 251 THR A C   1 
ATOM   1768 O O   . THR A 1 251 ? 213.876 279.708 346.722 1.00 92.43  ? 251 THR A O   1 
ATOM   1769 C CB  . THR A 1 251 ? 212.980 282.549 347.476 1.00 94.56  ? 251 THR A CB  1 
ATOM   1770 O OG1 . THR A 1 251 ? 213.150 283.865 348.017 1.00 96.84  ? 251 THR A OG1 1 
ATOM   1771 C CG2 . THR A 1 251 ? 211.519 282.145 347.575 1.00 93.15  ? 251 THR A CG2 1 
ATOM   1772 N N   . LYS A 1 252 ? 212.867 279.406 348.719 1.00 90.05  ? 252 LYS A N   1 
ATOM   1773 C CA  . LYS A 1 252 ? 212.509 278.024 348.435 1.00 88.61  ? 252 LYS A CA  1 
ATOM   1774 C C   . LYS A 1 252 ? 211.481 277.955 347.314 1.00 86.26  ? 252 LYS A C   1 
ATOM   1775 O O   . LYS A 1 252 ? 210.527 278.736 347.273 1.00 87.73  ? 252 LYS A O   1 
ATOM   1776 C CB  . LYS A 1 252 ? 211.958 277.348 349.689 1.00 86.44  ? 252 LYS A CB  1 
ATOM   1777 C CG  . LYS A 1 252 ? 211.472 275.925 349.460 1.00 86.36  ? 252 LYS A CG  1 
ATOM   1778 C CD  . LYS A 1 252 ? 211.050 275.261 350.756 1.00 87.47  ? 252 LYS A CD  1 
ATOM   1779 C CE  . LYS A 1 252 ? 210.551 273.847 350.511 1.00 89.53  ? 252 LYS A CE  1 
ATOM   1780 N NZ  . LYS A 1 252 ? 210.090 273.188 351.764 1.00 92.59  ? 252 LYS A NZ  1 
ATOM   1781 N N   . VAL A 1 253 ? 211.680 277.007 346.402 1.00 72.77  ? 253 VAL A N   1 
ATOM   1782 C CA  . VAL A 1 253 ? 210.786 276.785 345.272 1.00 70.37  ? 253 VAL A CA  1 
ATOM   1783 C C   . VAL A 1 253 ? 210.457 275.302 345.219 1.00 68.81  ? 253 VAL A C   1 
ATOM   1784 O O   . VAL A 1 253 ? 211.354 274.473 345.024 1.00 65.76  ? 253 VAL A O   1 
ATOM   1785 C CB  . VAL A 1 253 ? 211.413 277.244 343.947 1.00 68.17  ? 253 VAL A CB  1 
ATOM   1786 C CG1 . VAL A 1 253 ? 210.491 276.933 342.783 1.00 70.76  ? 253 VAL A CG1 1 
ATOM   1787 C CG2 . VAL A 1 253 ? 211.730 278.725 343.997 1.00 69.30  ? 253 VAL A CG2 1 
ATOM   1788 N N   . THR A 1 254 ? 209.183 274.965 345.383 1.00 73.55  ? 254 THR A N   1 
ATOM   1789 C CA  . THR A 1 254 ? 208.745 273.582 345.302 1.00 74.45  ? 254 THR A CA  1 
ATOM   1790 C C   . THR A 1 254 ? 208.262 273.277 343.890 1.00 73.35  ? 254 THR A C   1 
ATOM   1791 O O   . THR A 1 254 ? 207.889 274.174 343.132 1.00 81.42  ? 254 THR A O   1 
ATOM   1792 C CB  . THR A 1 254 ? 207.630 273.311 346.312 1.00 76.21  ? 254 THR A CB  1 
ATOM   1793 O OG1 . THR A 1 254 ? 208.029 273.783 347.605 1.00 82.45  ? 254 THR A OG1 1 
ATOM   1794 C CG2 . THR A 1 254 ? 207.327 271.823 346.395 1.00 73.02  ? 254 THR A CG2 1 
ATOM   1795 N N   . SER A 1 255 ? 208.269 271.992 343.542 1.00 58.97  ? 255 SER A N   1 
ATOM   1796 C CA  . SER A 1 255 ? 207.853 271.564 342.218 1.00 60.13  ? 255 SER A CA  1 
ATOM   1797 C C   . SER A 1 255 ? 207.316 270.146 342.312 1.00 61.88  ? 255 SER A C   1 
ATOM   1798 O O   . SER A 1 255 ? 207.685 269.381 343.207 1.00 71.88  ? 255 SER A O   1 
ATOM   1799 C CB  . SER A 1 255 ? 209.016 271.628 341.224 1.00 64.62  ? 255 SER A CB  1 
ATOM   1800 O OG  . SER A 1 255 ? 209.800 272.787 341.442 1.00 68.28  ? 255 SER A OG  1 
ATOM   1801 N N   . LYS A 1 256 ? 206.452 269.794 341.363 1.00 56.72  ? 256 LYS A N   1 
ATOM   1802 C CA  . LYS A 1 256 ? 205.776 268.500 341.376 1.00 58.82  ? 256 LYS A CA  1 
ATOM   1803 C C   . LYS A 1 256 ? 205.717 267.961 339.955 1.00 54.48  ? 256 LYS A C   1 
ATOM   1804 O O   . LYS A 1 256 ? 204.936 268.449 339.133 1.00 54.89  ? 256 LYS A O   1 
ATOM   1805 C CB  . LYS A 1 256 ? 204.376 268.621 341.975 1.00 59.44  ? 256 LYS A CB  1 
ATOM   1806 C CG  . LYS A 1 256 ? 204.361 269.287 343.340 1.00 58.70  ? 256 LYS A CG  1 
ATOM   1807 C CD  . LYS A 1 256 ? 202.968 269.317 343.941 1.00 56.46  ? 256 LYS A CD  1 
ATOM   1808 C CE  . LYS A 1 256 ? 202.563 267.963 344.492 1.00 59.32  ? 256 LYS A CE  1 
ATOM   1809 N NZ  . LYS A 1 256 ? 203.436 267.533 345.617 1.00 63.49  ? 256 LYS A NZ  1 
ATOM   1810 N N   . ILE A 1 257 ? 206.532 266.951 339.677 1.00 46.40  ? 257 ILE A N   1 
ATOM   1811 C CA  . ILE A 1 257 ? 206.543 266.300 338.374 1.00 49.10  ? 257 ILE A CA  1 
ATOM   1812 C C   . ILE A 1 257 ? 205.431 265.263 338.333 1.00 48.85  ? 257 ILE A C   1 
ATOM   1813 O O   . ILE A 1 257 ? 205.304 264.437 339.244 1.00 58.70  ? 257 ILE A O   1 
ATOM   1814 C CB  . ILE A 1 257 ? 207.910 265.652 338.100 1.00 51.57  ? 257 ILE A CB  1 
ATOM   1815 C CG1 . ILE A 1 257 ? 209.013 266.711 338.042 1.00 53.08  ? 257 ILE A CG1 1 
ATOM   1816 C CG2 . ILE A 1 257 ? 207.875 264.863 336.803 1.00 55.43  ? 257 ILE A CG2 1 
ATOM   1817 C CD1 . ILE A 1 257 ? 209.494 267.177 339.394 1.00 52.57  ? 257 ILE A CD1 1 
ATOM   1818 N N   . ARG A 1 258 ? 204.622 265.303 337.280 1.00 41.68  ? 258 ARG A N   1 
ATOM   1819 C CA  . ARG A 1 258 ? 203.574 264.320 337.050 1.00 51.01  ? 258 ARG A CA  1 
ATOM   1820 C C   . ARG A 1 258 ? 203.945 263.480 335.839 1.00 50.95  ? 258 ARG A C   1 
ATOM   1821 O O   . ARG A 1 258 ? 204.333 264.022 334.799 1.00 54.55  ? 258 ARG A O   1 
ATOM   1822 C CB  . ARG A 1 258 ? 202.221 264.998 336.836 1.00 53.03  ? 258 ARG A CB  1 
ATOM   1823 C CG  . ARG A 1 258 ? 201.637 265.597 338.097 1.00 55.48  ? 258 ARG A CG  1 
ATOM   1824 C CD  . ARG A 1 258 ? 200.303 266.264 337.836 1.00 58.82  ? 258 ARG A CD  1 
ATOM   1825 N NE  . ARG A 1 258 ? 199.718 266.796 339.060 1.00 58.03  ? 258 ARG A NE  1 
ATOM   1826 C CZ  . ARG A 1 258 ? 200.119 267.910 339.657 1.00 56.25  ? 258 ARG A CZ  1 
ATOM   1827 N NH1 . ARG A 1 258 ? 201.119 268.630 339.178 1.00 48.67  ? 258 ARG A NH1 1 
ATOM   1828 N NH2 . ARG A 1 258 ? 199.503 268.309 340.765 1.00 57.76  ? 258 ARG A NH2 1 
ATOM   1829 N N   . VAL A 1 259 ? 203.826 262.164 335.980 1.00 46.11  ? 259 VAL A N   1 
ATOM   1830 C CA  . VAL A 1 259 ? 204.221 261.212 334.950 1.00 37.17  ? 259 VAL A CA  1 
ATOM   1831 C C   . VAL A 1 259 ? 202.956 260.614 334.355 1.00 42.91  ? 259 VAL A C   1 
ATOM   1832 O O   . VAL A 1 259 ? 202.150 260.010 335.071 1.00 51.87  ? 259 VAL A O   1 
ATOM   1833 C CB  . VAL A 1 259 ? 205.132 260.114 335.516 1.00 42.23  ? 259 VAL A CB  1 
ATOM   1834 C CG1 . VAL A 1 259 ? 205.763 259.322 334.392 1.00 51.18  ? 259 VAL A CG1 1 
ATOM   1835 C CG2 . VAL A 1 259 ? 206.196 260.717 336.413 1.00 51.00  ? 259 VAL A CG2 1 
ATOM   1836 N N   . TYR A 1 260 ? 202.785 260.779 333.048 1.00 40.46  ? 260 TYR A N   1 
ATOM   1837 C CA  . TYR A 1 260 ? 201.640 260.259 332.316 1.00 44.86  ? 260 TYR A CA  1 
ATOM   1838 C C   . TYR A 1 260 ? 202.130 259.152 331.396 1.00 42.11  ? 260 TYR A C   1 
ATOM   1839 O O   . TYR A 1 260 ? 203.044 259.366 330.594 1.00 47.00  ? 260 TYR A O   1 
ATOM   1840 C CB  . TYR A 1 260 ? 200.949 261.372 331.531 1.00 39.54  ? 260 TYR A CB  1 
ATOM   1841 C CG  . TYR A 1 260 ? 200.339 262.424 332.427 1.00 44.48  ? 260 TYR A CG  1 
ATOM   1842 C CD1 . TYR A 1 260 ? 201.084 263.504 332.870 1.00 40.20  ? 260 TYR A CD1 1 
ATOM   1843 C CD2 . TYR A 1 260 ? 199.021 262.325 332.845 1.00 47.12  ? 260 TYR A CD2 1 
ATOM   1844 C CE1 . TYR A 1 260 ? 200.533 264.459 333.697 1.00 48.60  ? 260 TYR A CE1 1 
ATOM   1845 C CE2 . TYR A 1 260 ? 198.462 263.275 333.669 1.00 41.86  ? 260 TYR A CE2 1 
ATOM   1846 C CZ  . TYR A 1 260 ? 199.222 264.338 334.094 1.00 45.61  ? 260 TYR A CZ  1 
ATOM   1847 O OH  . TYR A 1 260 ? 198.664 265.287 334.919 1.00 43.56  ? 260 TYR A OH  1 
ATOM   1848 N N   . LEU A 1 261 ? 201.524 257.976 331.517 1.00 41.59  ? 261 LEU A N   1 
ATOM   1849 C CA  . LEU A 1 261 ? 201.998 256.760 330.872 1.00 40.18  ? 261 LEU A CA  1 
ATOM   1850 C C   . LEU A 1 261 ? 200.987 256.329 329.820 1.00 51.80  ? 261 LEU A C   1 
ATOM   1851 O O   . LEU A 1 261 ? 199.814 256.112 330.139 1.00 64.44  ? 261 LEU A O   1 
ATOM   1852 C CB  . LEU A 1 261 ? 202.199 255.661 331.915 1.00 43.44  ? 261 LEU A CB  1 
ATOM   1853 C CG  . LEU A 1 261 ? 202.890 254.363 331.505 1.00 47.65  ? 261 LEU A CG  1 
ATOM   1854 C CD1 . LEU A 1 261 ? 203.212 253.549 332.746 1.00 47.21  ? 261 LEU A CD1 1 
ATOM   1855 C CD2 . LEU A 1 261 ? 202.040 253.548 330.547 1.00 48.05  ? 261 LEU A CD2 1 
ATOM   1856 N N   . LYS A 1 262 ? 201.442 256.196 328.576 1.00 48.75  ? 262 LYS A N   1 
ATOM   1857 C CA  . LYS A 1 262 ? 200.601 255.734 327.478 1.00 47.04  ? 262 LYS A CA  1 
ATOM   1858 C C   . LYS A 1 262 ? 201.121 254.393 326.977 1.00 48.70  ? 262 LYS A C   1 
ATOM   1859 O O   . LYS A 1 262 ? 202.285 254.312 326.550 1.00 55.07  ? 262 LYS A O   1 
ATOM   1860 C CB  . LYS A 1 262 ? 200.579 256.751 326.337 1.00 43.97  ? 262 LYS A CB  1 
ATOM   1861 C CG  . LYS A 1 262 ? 199.753 256.308 325.143 1.00 46.87  ? 262 LYS A CG  1 
ATOM   1862 C CD  . LYS A 1 262 ? 199.901 257.253 323.970 1.00 50.63  ? 262 LYS A CD  1 
ATOM   1863 C CE  . LYS A 1 262 ? 199.290 256.655 322.714 1.00 55.93  ? 262 LYS A CE  1 
ATOM   1864 N NZ  . LYS A 1 262 ? 199.478 257.523 321.524 1.00 60.02  ? 262 LYS A NZ  1 
ATOM   1865 N N   . PRO A 1 263 ? 200.332 253.317 327.024 1.00 42.78  ? 263 PRO A N   1 
ATOM   1866 C CA  . PRO A 1 263 ? 200.747 252.060 326.383 1.00 43.74  ? 263 PRO A CA  1 
ATOM   1867 C C   . PRO A 1 263 ? 200.542 252.125 324.876 1.00 50.09  ? 263 PRO A C   1 
ATOM   1868 O O   . PRO A 1 263 ? 199.430 252.356 324.399 1.00 52.62  ? 263 PRO A O   1 
ATOM   1869 C CB  . PRO A 1 263 ? 199.830 251.014 327.030 1.00 44.35  ? 263 PRO A CB  1 
ATOM   1870 C CG  . PRO A 1 263 ? 199.271 251.669 328.241 1.00 42.60  ? 263 PRO A CG  1 
ATOM   1871 C CD  . PRO A 1 263 ? 199.176 253.112 327.909 1.00 38.66  ? 263 PRO A CD  1 
ATOM   1872 N N   . LYS A 1 264 ? 201.620 251.918 324.128 1.00 52.86  ? 264 LYS A N   1 
ATOM   1873 C CA  . LYS A 1 264 ? 201.581 251.808 322.679 1.00 52.46  ? 264 LYS A CA  1 
ATOM   1874 C C   . LYS A 1 264 ? 201.808 250.360 322.264 1.00 55.61  ? 264 LYS A C   1 
ATOM   1875 O O   . LYS A 1 264 ? 202.495 249.600 322.953 1.00 58.21  ? 264 LYS A O   1 
ATOM   1876 C CB  . LYS A 1 264 ? 202.650 252.683 322.020 1.00 46.71  ? 264 LYS A CB  1 
ATOM   1877 C CG  . LYS A 1 264 ? 202.649 254.131 322.448 1.00 49.33  ? 264 LYS A CG  1 
ATOM   1878 C CD  . LYS A 1 264 ? 203.558 254.966 321.556 1.00 57.75  ? 264 LYS A CD  1 
ATOM   1879 C CE  . LYS A 1 264 ? 204.995 254.462 321.566 1.00 65.70  ? 264 LYS A CE  1 
ATOM   1880 N NZ  . LYS A 1 264 ? 205.904 255.336 320.776 1.00 61.63  ? 264 LYS A NZ  1 
ATOM   1881 N N   . HIS A 1 265 ? 201.233 249.990 321.122 1.00 54.60  ? 265 HIS A N   1 
ATOM   1882 C CA  . HIS A 1 265 ? 201.447 248.668 320.540 1.00 55.54  ? 265 HIS A CA  1 
ATOM   1883 C C   . HIS A 1 265 ? 201.105 247.575 321.546 1.00 56.57  ? 265 HIS A C   1 
ATOM   1884 O O   . HIS A 1 265 ? 201.810 246.572 321.673 1.00 59.52  ? 265 HIS A O   1 
ATOM   1885 C CB  . HIS A 1 265 ? 202.886 248.517 320.049 1.00 54.22  ? 265 HIS A CB  1 
ATOM   1886 C CG  . HIS A 1 265 ? 203.418 249.725 319.340 1.00 59.09  ? 265 HIS A CG  1 
ATOM   1887 N ND1 . HIS A 1 265 ? 204.767 249.967 319.197 1.00 61.72  ? 265 HIS A ND1 1 
ATOM   1888 C CD2 . HIS A 1 265 ? 202.785 250.756 318.732 1.00 58.78  ? 265 HIS A CD2 1 
ATOM   1889 C CE1 . HIS A 1 265 ? 204.942 251.096 318.534 1.00 55.62  ? 265 HIS A CE1 1 
ATOM   1890 N NE2 . HIS A 1 265 ? 203.755 251.595 318.242 1.00 53.96  ? 265 HIS A NE2 1 
ATOM   1891 N N   . ILE A 1 266 ? 200.007 247.769 322.267 1.00 43.31  ? 266 ILE A N   1 
ATOM   1892 C CA  . ILE A 1 266 ? 199.682 246.916 323.403 1.00 43.27  ? 266 ILE A CA  1 
ATOM   1893 C C   . ILE A 1 266 ? 198.936 245.677 322.925 1.00 40.79  ? 266 ILE A C   1 
ATOM   1894 O O   . ILE A 1 266 ? 198.002 245.765 322.120 1.00 49.04  ? 266 ILE A O   1 
ATOM   1895 C CB  . ILE A 1 266 ? 198.865 247.691 324.450 1.00 38.55  ? 266 ILE A CB  1 
ATOM   1896 C CG1 . ILE A 1 266 ? 198.433 246.758 325.579 1.00 36.63  ? 266 ILE A CG1 1 
ATOM   1897 C CG2 . ILE A 1 266 ? 197.654 248.355 323.815 1.00 42.20  ? 266 ILE A CG2 1 
ATOM   1898 C CD1 . ILE A 1 266 ? 198.075 247.482 326.856 1.00 40.45  ? 266 ILE A CD1 1 
ATOM   1899 N N   . ARG A 1 267 ? 199.369 244.516 323.408 1.00 29.69  ? 267 ARG A N   1 
ATOM   1900 C CA  . ARG A 1 267 ? 198.670 243.251 323.244 1.00 35.60  ? 267 ARG A CA  1 
ATOM   1901 C C   . ARG A 1 267 ? 198.399 242.679 324.625 1.00 33.32  ? 267 ARG A C   1 
ATOM   1902 O O   . ARG A 1 267 ? 199.270 242.719 325.497 1.00 39.11  ? 267 ARG A O   1 
ATOM   1903 C CB  . ARG A 1 267 ? 199.495 242.256 322.430 1.00 29.23  ? 267 ARG A CB  1 
ATOM   1904 C CG  . ARG A 1 267 ? 199.816 242.712 321.028 1.00 37.24  ? 267 ARG A CG  1 
ATOM   1905 C CD  . ARG A 1 267 ? 200.880 241.831 320.399 1.00 38.53  ? 267 ARG A CD  1 
ATOM   1906 N NE  . ARG A 1 267 ? 200.519 240.419 320.436 1.00 34.19  ? 267 ARG A NE  1 
ATOM   1907 C CZ  . ARG A 1 267 ? 201.254 239.446 319.917 1.00 39.95  ? 267 ARG A CZ  1 
ATOM   1908 N NH1 . ARG A 1 267 ? 202.401 239.695 319.309 1.00 45.31  ? 267 ARG A NH1 1 
ATOM   1909 N NH2 . ARG A 1 267 ? 200.826 238.191 320.010 1.00 40.17  ? 267 ARG A NH2 1 
ATOM   1910 N N   . VAL A 1 268 ? 197.196 242.149 324.830 1.00 28.65  ? 268 VAL A N   1 
ATOM   1911 C CA  . VAL A 1 268 ? 196.791 241.653 326.138 1.00 28.57  ? 268 VAL A CA  1 
ATOM   1912 C C   . VAL A 1 268 ? 196.285 240.225 326.007 1.00 38.57  ? 268 VAL A C   1 
ATOM   1913 O O   . VAL A 1 268 ? 195.818 239.803 324.945 1.00 41.60  ? 268 VAL A O   1 
ATOM   1914 C CB  . VAL A 1 268 ? 195.716 242.548 326.783 1.00 28.53  ? 268 VAL A CB  1 
ATOM   1915 C CG1 . VAL A 1 268 ? 196.332 243.847 327.257 1.00 38.28  ? 268 VAL A CG1 1 
ATOM   1916 C CG2 . VAL A 1 268 ? 194.594 242.816 325.804 1.00 47.50  ? 268 VAL A CG2 1 
ATOM   1917 N N   . TRP A 1 269 ? 196.378 239.485 327.111 1.00 38.87  ? 269 TRP A N   1 
ATOM   1918 C CA  . TRP A 1 269 ? 196.063 238.066 327.138 1.00 34.39  ? 269 TRP A CA  1 
ATOM   1919 C C   . TRP A 1 269 ? 195.345 237.709 328.430 1.00 36.45  ? 269 TRP A C   1 
ATOM   1920 O O   . TRP A 1 269 ? 195.629 238.269 329.496 1.00 42.17  ? 269 TRP A O   1 
ATOM   1921 C CB  . TRP A 1 269 ? 197.321 237.199 327.032 1.00 38.80  ? 269 TRP A CB  1 
ATOM   1922 C CG  . TRP A 1 269 ? 198.016 237.252 325.717 1.00 39.85  ? 269 TRP A CG  1 
ATOM   1923 C CD1 . TRP A 1 269 ? 197.702 236.545 324.599 1.00 47.34  ? 269 TRP A CD1 1 
ATOM   1924 C CD2 . TRP A 1 269 ? 199.163 238.038 325.386 1.00 31.46  ? 269 TRP A CD2 1 
ATOM   1925 N NE1 . TRP A 1 269 ? 198.576 236.846 323.587 1.00 34.56  ? 269 TRP A NE1 1 
ATOM   1926 C CE2 . TRP A 1 269 ? 199.484 237.761 324.046 1.00 28.79  ? 269 TRP A CE2 1 
ATOM   1927 C CE3 . TRP A 1 269 ? 199.948 238.951 326.093 1.00 39.11  ? 269 TRP A CE3 1 
ATOM   1928 C CZ2 . TRP A 1 269 ? 200.551 238.364 323.398 1.00 36.88  ? 269 TRP A CZ2 1 
ATOM   1929 C CZ3 . TRP A 1 269 ? 201.005 239.548 325.449 1.00 43.89  ? 269 TRP A CZ3 1 
ATOM   1930 C CH2 . TRP A 1 269 ? 201.299 239.253 324.114 1.00 47.57  ? 269 TRP A CH2 1 
ATOM   1931 N N   . CYS A 1 270 ? 194.446 236.720 328.321 1.00 31.86  ? 270 CYS A N   1 
ATOM   1932 C CA  . CYS A 1 270 ? 193.747 236.106 329.444 1.00 32.21  ? 270 CYS A CA  1 
ATOM   1933 C C   . CYS A 1 270 ? 192.914 237.118 330.219 1.00 33.24  ? 270 CYS A C   1 
ATOM   1934 O O   . CYS A 1 270 ? 193.285 237.499 331.336 1.00 38.55  ? 270 CYS A O   1 
ATOM   1935 C CB  . CYS A 1 270 ? 194.746 235.420 330.375 1.00 42.59  ? 270 CYS A CB  1 
ATOM   1936 S SG  . CYS A 1 270 ? 195.474 233.924 329.681 1.00 54.69  ? 270 CYS A SG  1 
ATOM   1937 N N   . PRO A 1 271 ? 191.791 237.575 329.668 1.00 34.21  ? 271 PRO A N   1 
ATOM   1938 C CA  . PRO A 1 271 ? 190.985 238.588 330.357 1.00 34.03  ? 271 PRO A CA  1 
ATOM   1939 C C   . PRO A 1 271 ? 190.580 238.135 331.750 1.00 32.66  ? 271 PRO A C   1 
ATOM   1940 O O   . PRO A 1 271 ? 190.682 236.964 332.120 1.00 31.66  ? 271 PRO A O   1 
ATOM   1941 C CB  . PRO A 1 271 ? 189.767 238.757 329.446 1.00 27.77  ? 271 PRO A CB  1 
ATOM   1942 C CG  . PRO A 1 271 ? 189.696 237.495 328.670 1.00 32.68  ? 271 PRO A CG  1 
ATOM   1943 C CD  . PRO A 1 271 ? 191.112 237.062 328.468 1.00 34.05  ? 271 PRO A CD  1 
ATOM   1944 N N   . ARG A 1 272 ? 190.111 239.099 332.533 1.00 31.18  ? 272 ARG A N   1 
ATOM   1945 C CA  . ARG A 1 272 ? 189.716 238.865 333.914 1.00 30.97  ? 272 ARG A CA  1 
ATOM   1946 C C   . ARG A 1 272 ? 188.524 239.753 334.241 1.00 37.00  ? 272 ARG A C   1 
ATOM   1947 O O   . ARG A 1 272 ? 188.134 240.586 333.415 1.00 54.98  ? 272 ARG A O   1 
ATOM   1948 C CB  . ARG A 1 272 ? 190.881 239.154 334.861 1.00 32.19  ? 272 ARG A CB  1 
ATOM   1949 C CG  . ARG A 1 272 ? 192.131 238.350 334.573 1.00 41.11  ? 272 ARG A CG  1 
ATOM   1950 C CD  . ARG A 1 272 ? 193.228 238.687 335.558 1.00 39.75  ? 272 ARG A CD  1 
ATOM   1951 N NE  . ARG A 1 272 ? 192.910 238.240 336.908 1.00 40.42  ? 272 ARG A NE  1 
ATOM   1952 C CZ  . ARG A 1 272 ? 193.263 237.068 337.416 1.00 37.43  ? 272 ARG A CZ  1 
ATOM   1953 N NH1 . ARG A 1 272 ? 193.947 236.184 336.710 1.00 39.93  ? 272 ARG A NH1 1 
ATOM   1954 N NH2 . ARG A 1 272 ? 192.925 236.776 338.668 1.00 41.95  ? 272 ARG A NH2 1 
ATOM   1955 N N   . PRO A 1 273 ? 187.918 239.616 335.415 1.00 27.60  ? 273 PRO A N   1 
ATOM   1956 C CA  . PRO A 1 273 ? 186.829 240.507 335.786 1.00 29.31  ? 273 PRO A CA  1 
ATOM   1957 C C   . PRO A 1 273 ? 187.368 241.777 336.417 1.00 42.87  ? 273 PRO A C   1 
ATOM   1958 O O   . PRO A 1 273 ? 188.272 241.720 337.263 1.00 45.30  ? 273 PRO A O   1 
ATOM   1959 C CB  . PRO A 1 273 ? 186.018 239.680 336.795 1.00 35.88  ? 273 PRO A CB  1 
ATOM   1960 C CG  . PRO A 1 273 ? 186.821 238.437 337.069 1.00 42.52  ? 273 PRO A CG  1 
ATOM   1961 C CD  . PRO A 1 273 ? 188.164 238.617 336.460 1.00 39.73  ? 273 PRO A CD  1 
ATOM   1962 N N   . PRO A 1 274 ? 186.847 242.941 336.036 1.00 52.15  ? 274 PRO A N   1 
ATOM   1963 C CA  . PRO A 1 274 ? 187.390 244.192 336.573 1.00 48.20  ? 274 PRO A CA  1 
ATOM   1964 C C   . PRO A 1 274 ? 187.189 244.293 338.075 1.00 52.81  ? 274 PRO A C   1 
ATOM   1965 O O   . PRO A 1 274 ? 186.231 243.758 338.636 1.00 55.39  ? 274 PRO A O   1 
ATOM   1966 C CB  . PRO A 1 274 ? 186.599 245.271 335.829 1.00 49.20  ? 274 PRO A CB  1 
ATOM   1967 C CG  . PRO A 1 274 ? 185.340 244.603 335.422 1.00 54.65  ? 274 PRO A CG  1 
ATOM   1968 C CD  . PRO A 1 274 ? 185.701 243.179 335.144 1.00 49.07  ? 274 PRO A CD  1 
ATOM   1969 N N   . ARG A 1 275 ? 188.113 244.992 338.726 1.00 52.59  ? 275 ARG A N   1 
ATOM   1970 C CA  . ARG A 1 275 ? 188.018 245.196 340.163 1.00 53.53  ? 275 ARG A CA  1 
ATOM   1971 C C   . ARG A 1 275 ? 186.695 245.863 340.515 1.00 56.76  ? 275 ARG A C   1 
ATOM   1972 O O   . ARG A 1 275 ? 186.256 246.804 339.849 1.00 57.31  ? 275 ARG A O   1 
ATOM   1973 C CB  . ARG A 1 275 ? 189.184 246.056 340.645 1.00 50.52  ? 275 ARG A CB  1 
ATOM   1974 C CG  . ARG A 1 275 ? 189.278 246.195 342.153 1.00 51.85  ? 275 ARG A CG  1 
ATOM   1975 C CD  . ARG A 1 275 ? 190.054 245.049 342.768 1.00 54.91  ? 275 ARG A CD  1 
ATOM   1976 N NE  . ARG A 1 275 ? 190.207 245.208 344.208 1.00 57.69  ? 275 ARG A NE  1 
ATOM   1977 C CZ  . ARG A 1 275 ? 191.052 244.509 344.951 1.00 54.03  ? 275 ARG A CZ  1 
ATOM   1978 N NH1 . ARG A 1 275 ? 191.852 243.600 344.419 1.00 54.00  ? 275 ARG A NH1 1 
ATOM   1979 N NH2 . ARG A 1 275 ? 191.098 244.728 346.261 1.00 51.53  ? 275 ARG A NH2 1 
ATOM   1980 N N   . ALA A 1 276 ? 186.058 245.369 341.573 1.00 58.15  ? 276 ALA A N   1 
ATOM   1981 C CA  . ALA A 1 276 ? 184.789 245.905 342.052 1.00 58.27  ? 276 ALA A CA  1 
ATOM   1982 C C   . ALA A 1 276 ? 184.926 246.736 343.315 1.00 59.40  ? 276 ALA A C   1 
ATOM   1983 O O   . ALA A 1 276 ? 184.199 247.717 343.480 1.00 60.70  ? 276 ALA A O   1 
ATOM   1984 C CB  . ALA A 1 276 ? 183.800 244.765 342.310 1.00 60.44  ? 276 ALA A CB  1 
ATOM   1985 N N   . VAL A 1 277 ? 185.840 246.372 344.209 1.00 58.35  ? 277 VAL A N   1 
ATOM   1986 C CA  . VAL A 1 277 ? 186.050 247.097 345.453 1.00 58.69  ? 277 VAL A CA  1 
ATOM   1987 C C   . VAL A 1 277 ? 187.379 247.836 345.374 1.00 67.72  ? 277 VAL A C   1 
ATOM   1988 O O   . VAL A 1 277 ? 188.279 247.480 344.607 1.00 65.73  ? 277 VAL A O   1 
ATOM   1989 C CB  . VAL A 1 277 ? 186.010 246.163 346.679 1.00 53.44  ? 277 VAL A CB  1 
ATOM   1990 C CG1 . VAL A 1 277 ? 184.592 245.711 346.946 1.00 63.56  ? 277 VAL A CG1 1 
ATOM   1991 C CG2 . VAL A 1 277 ? 186.911 244.965 346.467 1.00 60.84  ? 277 VAL A CG2 1 
ATOM   1992 N N   . ALA A 1 278 ? 187.499 248.881 346.190 1.00 72.32  ? 278 ALA A N   1 
ATOM   1993 C CA  . ALA A 1 278 ? 188.662 249.754 346.116 1.00 64.02  ? 278 ALA A CA  1 
ATOM   1994 C C   . ALA A 1 278 ? 189.937 248.975 346.401 1.00 62.27  ? 278 ALA A C   1 
ATOM   1995 O O   . ALA A 1 278 ? 189.961 248.071 347.239 1.00 66.78  ? 278 ALA A O   1 
ATOM   1996 C CB  . ALA A 1 278 ? 188.522 250.911 347.104 1.00 58.71  ? 278 ALA A CB  1 
ATOM   1997 N N   . TYR A 1 279 ? 191.003 249.337 345.694 1.00 53.27  ? 279 TYR A N   1 
ATOM   1998 C CA  . TYR A 1 279 ? 192.274 248.654 345.844 1.00 53.75  ? 279 TYR A CA  1 
ATOM   1999 C C   . TYR A 1 279 ? 192.831 248.853 347.252 1.00 56.59  ? 279 TYR A C   1 
ATOM   2000 O O   . TYR A 1 279 ? 192.417 249.739 348.002 1.00 61.84  ? 279 TYR A O   1 
ATOM   2001 C CB  . TYR A 1 279 ? 193.275 249.165 344.812 1.00 55.28  ? 279 TYR A CB  1 
ATOM   2002 C CG  . TYR A 1 279 ? 192.980 248.710 343.408 1.00 56.02  ? 279 TYR A CG  1 
ATOM   2003 C CD1 . TYR A 1 279 ? 192.118 249.423 342.592 1.00 57.94  ? 279 TYR A CD1 1 
ATOM   2004 C CD2 . TYR A 1 279 ? 193.563 247.564 342.898 1.00 56.70  ? 279 TYR A CD2 1 
ATOM   2005 C CE1 . TYR A 1 279 ? 191.849 249.005 341.308 1.00 60.15  ? 279 TYR A CE1 1 
ATOM   2006 C CE2 . TYR A 1 279 ? 193.301 247.141 341.618 1.00 57.55  ? 279 TYR A CE2 1 
ATOM   2007 C CZ  . TYR A 1 279 ? 192.444 247.863 340.828 1.00 61.22  ? 279 TYR A CZ  1 
ATOM   2008 O OH  . TYR A 1 279 ? 192.183 247.436 339.551 1.00 63.04  ? 279 TYR A OH  1 
ATOM   2009 N N   . TYR A 1 280 ? 193.787 247.996 347.607 1.00 60.03  ? 280 TYR A N   1 
ATOM   2010 C CA  . TYR A 1 280 ? 194.502 248.121 348.878 1.00 64.79  ? 280 TYR A CA  1 
ATOM   2011 C C   . TYR A 1 280 ? 195.921 247.596 348.649 1.00 69.67  ? 280 TYR A C   1 
ATOM   2012 O O   . TYR A 1 280 ? 196.171 246.392 348.733 1.00 69.58  ? 280 TYR A O   1 
ATOM   2013 C CB  . TYR A 1 280 ? 193.795 247.368 349.993 1.00 66.50  ? 280 TYR A CB  1 
ATOM   2014 C CG  . TYR A 1 280 ? 194.419 247.567 351.354 1.00 67.46  ? 280 TYR A CG  1 
ATOM   2015 C CD1 . TYR A 1 280 ? 194.204 248.733 352.073 1.00 70.84  ? 280 TYR A CD1 1 
ATOM   2016 C CD2 . TYR A 1 280 ? 195.220 246.588 351.920 1.00 64.90  ? 280 TYR A CD2 1 
ATOM   2017 C CE1 . TYR A 1 280 ? 194.771 248.920 353.316 1.00 70.94  ? 280 TYR A CE1 1 
ATOM   2018 C CE2 . TYR A 1 280 ? 195.791 246.765 353.162 1.00 67.06  ? 280 TYR A CE2 1 
ATOM   2019 C CZ  . TYR A 1 280 ? 195.564 247.932 353.856 1.00 71.42  ? 280 TYR A CZ  1 
ATOM   2020 O OH  . TYR A 1 280 ? 196.133 248.113 355.096 1.00 75.91  ? 280 TYR A OH  1 
ATOM   2021 N N   . GLY A 1 281 ? 196.839 248.513 348.361 1.00 69.27  ? 281 GLY A N   1 
ATOM   2022 C CA  . GLY A 1 281 ? 198.224 248.164 348.163 1.00 66.39  ? 281 GLY A CA  1 
ATOM   2023 C C   . GLY A 1 281 ? 198.476 247.513 346.819 1.00 63.15  ? 281 GLY A C   1 
ATOM   2024 O O   . GLY A 1 281 ? 197.636 247.554 345.915 1.00 64.48  ? 281 GLY A O   1 
ATOM   2025 N N   . PRO A 1 282 ? 199.652 246.899 346.660 1.00 68.59  ? 282 PRO A N   1 
ATOM   2026 C CA  . PRO A 1 282 ? 199.974 246.276 345.366 1.00 70.37  ? 282 PRO A CA  1 
ATOM   2027 C C   . PRO A 1 282 ? 199.227 244.980 345.112 1.00 65.04  ? 282 PRO A C   1 
ATOM   2028 O O   . PRO A 1 282 ? 198.959 244.653 343.949 1.00 62.22  ? 282 PRO A O   1 
ATOM   2029 C CB  . PRO A 1 282 ? 201.489 246.036 345.454 1.00 64.97  ? 282 PRO A CB  1 
ATOM   2030 C CG  . PRO A 1 282 ? 201.960 246.808 346.651 1.00 63.59  ? 282 PRO A CG  1 
ATOM   2031 C CD  . PRO A 1 282 ? 200.799 246.881 347.578 1.00 66.67  ? 282 PRO A CD  1 
ATOM   2032 N N   . GLY A 1 283 ? 198.881 244.234 346.154 1.00 57.14  ? 283 GLY A N   1 
ATOM   2033 C CA  . GLY A 1 283 ? 198.289 242.925 345.993 1.00 55.98  ? 283 GLY A CA  1 
ATOM   2034 C C   . GLY A 1 283 ? 196.822 242.997 345.621 1.00 55.12  ? 283 GLY A C   1 
ATOM   2035 O O   . GLY A 1 283 ? 196.290 244.035 345.225 1.00 58.89  ? 283 GLY A O   1 
ATOM   2036 N N   . VAL A 1 284 ? 196.160 241.853 345.757 1.00 49.38  ? 284 VAL A N   1 
ATOM   2037 C CA  . VAL A 1 284 ? 194.732 241.746 345.500 1.00 45.01  ? 284 VAL A CA  1 
ATOM   2038 C C   . VAL A 1 284 ? 193.931 241.818 346.800 1.00 48.10  ? 284 VAL A C   1 
ATOM   2039 O O   . VAL A 1 284 ? 192.804 241.333 346.859 1.00 59.35  ? 284 VAL A O   1 
ATOM   2040 C CB  . VAL A 1 284 ? 194.395 240.468 344.716 1.00 45.53  ? 284 VAL A CB  1 
ATOM   2041 C CG1 . VAL A 1 284 ? 195.056 240.488 343.347 1.00 49.29  ? 284 VAL A CG1 1 
ATOM   2042 C CG2 . VAL A 1 284 ? 194.817 239.235 345.492 1.00 56.03  ? 284 VAL A CG2 1 
ATOM   2043 N N   . ASP A 1 285 ? 194.502 242.408 347.846 1.00 51.52  ? 285 ASP A N   1 
ATOM   2044 C CA  . ASP A 1 285 ? 193.811 242.511 349.119 1.00 53.18  ? 285 ASP A CA  1 
ATOM   2045 C C   . ASP A 1 285 ? 192.731 243.586 349.057 1.00 59.57  ? 285 ASP A C   1 
ATOM   2046 O O   . ASP A 1 285 ? 192.777 244.509 348.240 1.00 67.33  ? 285 ASP A O   1 
ATOM   2047 C CB  . ASP A 1 285 ? 194.800 242.833 350.237 1.00 59.07  ? 285 ASP A CB  1 
ATOM   2048 C CG  . ASP A 1 285 ? 195.997 241.906 350.240 1.00 68.35  ? 285 ASP A CG  1 
ATOM   2049 O OD1 . ASP A 1 285 ? 196.172 241.154 349.261 1.00 71.37  ? 285 ASP A OD1 1 
ATOM   2050 O OD2 . ASP A 1 285 ? 196.764 241.926 351.225 1.00 67.06  ? 285 ASP A OD2 1 
ATOM   2051 N N   . TYR A 1 286 ? 191.743 243.452 349.937 1.00 60.02  ? 286 TYR A N   1 
ATOM   2052 C CA  . TYR A 1 286 ? 190.692 244.444 350.094 1.00 58.82  ? 286 TYR A CA  1 
ATOM   2053 C C   . TYR A 1 286 ? 190.504 244.743 351.573 1.00 58.36  ? 286 TYR A C   1 
ATOM   2054 O O   . TYR A 1 286 ? 190.665 243.868 352.426 1.00 57.00  ? 286 TYR A O   1 
ATOM   2055 C CB  . TYR A 1 286 ? 189.368 243.976 349.478 1.00 59.92  ? 286 TYR A CB  1 
ATOM   2056 C CG  . TYR A 1 286 ? 189.146 242.482 349.534 1.00 63.57  ? 286 TYR A CG  1 
ATOM   2057 C CD1 . TYR A 1 286 ? 188.978 241.828 350.745 1.00 62.23  ? 286 TYR A CD1 1 
ATOM   2058 C CD2 . TYR A 1 286 ? 189.089 241.727 348.372 1.00 59.28  ? 286 TYR A CD2 1 
ATOM   2059 C CE1 . TYR A 1 286 ? 188.772 240.467 350.795 1.00 56.43  ? 286 TYR A CE1 1 
ATOM   2060 C CE2 . TYR A 1 286 ? 188.884 240.369 348.414 1.00 52.97  ? 286 TYR A CE2 1 
ATOM   2061 C CZ  . TYR A 1 286 ? 188.723 239.745 349.627 1.00 53.18  ? 286 TYR A CZ  1 
ATOM   2062 O OH  . TYR A 1 286 ? 188.519 238.388 349.669 1.00 61.86  ? 286 TYR A OH  1 
ATOM   2063 N N   . LYS A 1 287 ? 190.162 245.993 351.866 1.00 70.20  ? 287 LYS A N   1 
ATOM   2064 C CA  . LYS A 1 287 ? 190.046 246.439 353.243 1.00 73.66  ? 287 LYS A CA  1 
ATOM   2065 C C   . LYS A 1 287 ? 188.729 245.959 353.851 1.00 76.95  ? 287 LYS A C   1 
ATOM   2066 O O   . LYS A 1 287 ? 187.818 245.501 353.157 1.00 78.69  ? 287 LYS A O   1 
ATOM   2067 C CB  . LYS A 1 287 ? 190.162 247.960 353.316 1.00 74.44  ? 287 LYS A CB  1 
ATOM   2068 C CG  . LYS A 1 287 ? 190.399 248.500 354.718 1.00 75.35  ? 287 LYS A CG  1 
ATOM   2069 C CD  . LYS A 1 287 ? 191.413 249.635 354.727 1.00 71.30  ? 287 LYS A CD  1 
ATOM   2070 C CE  . LYS A 1 287 ? 190.996 250.785 353.824 1.00 74.77  ? 287 LYS A CE  1 
ATOM   2071 N NZ  . LYS A 1 287 ? 189.642 251.302 354.158 1.00 71.37  ? 287 LYS A NZ  1 
ATOM   2072 N N   . ASP A 1 288 ? 188.638 246.071 355.177 1.00 84.14  ? 288 ASP A N   1 
ATOM   2073 C CA  . ASP A 1 288 ? 187.527 245.465 355.905 1.00 86.07  ? 288 ASP A CA  1 
ATOM   2074 C C   . ASP A 1 288 ? 186.188 246.061 355.484 1.00 85.39  ? 288 ASP A C   1 
ATOM   2075 O O   . ASP A 1 288 ? 185.234 245.330 355.194 1.00 84.52  ? 288 ASP A O   1 
ATOM   2076 C CB  . ASP A 1 288 ? 187.742 245.638 357.408 1.00 84.83  ? 288 ASP A CB  1 
ATOM   2077 C CG  . ASP A 1 288 ? 186.806 244.782 358.235 1.00 85.12  ? 288 ASP A CG  1 
ATOM   2078 O OD1 . ASP A 1 288 ? 185.999 244.037 357.640 1.00 84.61  ? 288 ASP A OD1 1 
ATOM   2079 O OD2 . ASP A 1 288 ? 186.877 244.853 359.479 1.00 84.19  ? 288 ASP A OD2 1 
ATOM   2080 N N   . GLY A 1 289 ? 186.095 247.385 355.445 1.00 75.50  ? 289 GLY A N   1 
ATOM   2081 C CA  . GLY A 1 289 ? 184.834 248.059 355.224 1.00 76.55  ? 289 GLY A CA  1 
ATOM   2082 C C   . GLY A 1 289 ? 184.485 248.364 353.784 1.00 77.11  ? 289 GLY A C   1 
ATOM   2083 O O   . GLY A 1 289 ? 183.473 249.028 353.538 1.00 78.04  ? 289 GLY A O   1 
ATOM   2084 N N   . THR A 1 290 ? 185.280 247.904 352.824 1.00 73.51  ? 290 THR A N   1 
ATOM   2085 C CA  . THR A 1 290 ? 185.077 248.239 351.421 1.00 74.25  ? 290 THR A CA  1 
ATOM   2086 C C   . THR A 1 290 ? 184.254 247.200 350.669 1.00 73.01  ? 290 THR A C   1 
ATOM   2087 O O   . THR A 1 290 ? 184.057 247.345 349.459 1.00 75.88  ? 290 THR A O   1 
ATOM   2088 C CB  . THR A 1 290 ? 186.433 248.412 350.730 1.00 75.79  ? 290 THR A CB  1 
ATOM   2089 O OG1 . THR A 1 290 ? 187.292 249.207 351.556 1.00 79.39  ? 290 THR A OG1 1 
ATOM   2090 C CG2 . THR A 1 290 ? 186.271 249.094 349.383 1.00 73.81  ? 290 THR A CG2 1 
ATOM   2091 N N   . LEU A 1 291 ? 183.759 246.170 351.347 1.00 74.30  ? 291 LEU A N   1 
ATOM   2092 C CA  . LEU A 1 291 ? 183.135 245.030 350.676 1.00 73.88  ? 291 LEU A CA  1 
ATOM   2093 C C   . LEU A 1 291 ? 181.632 245.225 350.494 1.00 73.05  ? 291 LEU A C   1 
ATOM   2094 O O   . LEU A 1 291 ? 180.832 244.373 350.875 1.00 74.36  ? 291 LEU A O   1 
ATOM   2095 C CB  . LEU A 1 291 ? 183.427 243.760 351.465 1.00 72.24  ? 291 LEU A CB  1 
ATOM   2096 C CG  . LEU A 1 291 ? 184.849 243.632 352.015 1.00 72.46  ? 291 LEU A CG  1 
ATOM   2097 C CD1 . LEU A 1 291 ? 184.979 242.376 352.852 1.00 72.50  ? 291 LEU A CD1 1 
ATOM   2098 C CD2 . LEU A 1 291 ? 185.873 243.633 350.896 1.00 70.16  ? 291 LEU A CD2 1 
ATOM   2099 N N   . THR A 1 292 ? 181.230 246.353 349.903 1.00 74.63  ? 292 THR A N   1 
ATOM   2100 C CA  . THR A 1 292 ? 179.820 246.624 349.608 1.00 77.28  ? 292 THR A CA  1 
ATOM   2101 C C   . THR A 1 292 ? 179.733 247.443 348.328 1.00 78.79  ? 292 THR A C   1 
ATOM   2102 O O   . THR A 1 292 ? 179.375 248.626 348.346 1.00 80.19  ? 292 THR A O   1 
ATOM   2103 C CB  . THR A 1 292 ? 179.144 247.355 350.768 1.00 78.08  ? 292 THR A CB  1 
ATOM   2104 O OG1 . THR A 1 292 ? 179.649 248.693 350.855 1.00 82.51  ? 292 THR A OG1 1 
ATOM   2105 C CG2 . THR A 1 292 ? 179.390 246.638 352.089 1.00 76.50  ? 292 THR A CG2 1 
ATOM   2106 N N   . PRO A 1 293 ? 180.060 246.837 347.183 1.00 73.05  ? 293 PRO A N   1 
ATOM   2107 C CA  . PRO A 1 293 ? 180.037 247.610 345.930 1.00 72.68  ? 293 PRO A CA  1 
ATOM   2108 C C   . PRO A 1 293 ? 178.641 247.910 345.413 1.00 74.01  ? 293 PRO A C   1 
ATOM   2109 O O   . PRO A 1 293 ? 178.382 249.038 344.975 1.00 77.41  ? 293 PRO A O   1 
ATOM   2110 C CB  . PRO A 1 293 ? 180.820 246.713 344.962 1.00 72.11  ? 293 PRO A CB  1 
ATOM   2111 C CG  . PRO A 1 293 ? 180.625 245.337 345.491 1.00 72.13  ? 293 PRO A CG  1 
ATOM   2112 C CD  . PRO A 1 293 ? 180.576 245.473 346.984 1.00 70.39  ? 293 PRO A CD  1 
ATOM   2113 N N   . LEU A 1 294 ? 177.730 246.941 345.450 1.00 68.91  ? 294 LEU A N   1 
ATOM   2114 C CA  . LEU A 1 294 ? 176.449 247.087 344.774 1.00 71.99  ? 294 LEU A CA  1 
ATOM   2115 C C   . LEU A 1 294 ? 175.531 248.031 345.553 1.00 70.35  ? 294 LEU A C   1 
ATOM   2116 O O   . LEU A 1 294 ? 175.856 248.507 346.644 1.00 72.38  ? 294 LEU A O   1 
ATOM   2117 C CB  . LEU A 1 294 ? 175.800 245.719 344.579 1.00 66.86  ? 294 LEU A CB  1 
ATOM   2118 C CG  . LEU A 1 294 ? 176.607 244.759 343.701 1.00 68.78  ? 294 LEU A CG  1 
ATOM   2119 C CD1 . LEU A 1 294 ? 175.920 243.413 343.587 1.00 70.14  ? 294 LEU A CD1 1 
ATOM   2120 C CD2 . LEU A 1 294 ? 176.836 245.356 342.322 1.00 67.64  ? 294 LEU A CD2 1 
ATOM   2121 N N   . SER A 1 295 ? 174.361 248.299 344.973 1.00 72.26  ? 295 SER A N   1 
ATOM   2122 C CA  . SER A 1 295 ? 173.426 249.285 345.493 1.00 75.70  ? 295 SER A CA  1 
ATOM   2123 C C   . SER A 1 295 ? 172.042 248.666 345.635 1.00 77.72  ? 295 SER A C   1 
ATOM   2124 O O   . SER A 1 295 ? 171.704 247.686 344.966 1.00 82.01  ? 295 SER A O   1 
ATOM   2125 C CB  . SER A 1 295 ? 173.352 250.514 344.580 1.00 76.64  ? 295 SER A CB  1 
ATOM   2126 O OG  . SER A 1 295 ? 174.648 250.992 344.267 1.00 75.55  ? 295 SER A OG  1 
ATOM   2127 N N   . THR A 1 296 ? 171.238 249.258 346.515 1.00 78.26  ? 296 THR A N   1 
ATOM   2128 C CA  . THR A 1 296 ? 169.907 248.735 346.790 1.00 80.13  ? 296 THR A CA  1 
ATOM   2129 C C   . THR A 1 296 ? 168.995 248.893 345.579 1.00 79.89  ? 296 THR A C   1 
ATOM   2130 O O   . THR A 1 296 ? 168.999 249.927 344.907 1.00 79.63  ? 296 THR A O   1 
ATOM   2131 C CB  . THR A 1 296 ? 169.293 249.452 347.992 1.00 78.97  ? 296 THR A CB  1 
ATOM   2132 O OG1 . THR A 1 296 ? 170.163 249.330 349.123 1.00 79.19  ? 296 THR A OG1 1 
ATOM   2133 C CG2 . THR A 1 296 ? 167.935 248.855 348.333 1.00 75.99  ? 296 THR A CG2 1 
ATOM   2134 N N   . LYS A 1 297 ? 168.209 247.853 345.307 1.00 82.81  ? 297 LYS A N   1 
ATOM   2135 C CA  . LYS A 1 297 ? 167.219 247.889 344.237 1.00 83.72  ? 297 LYS A CA  1 
ATOM   2136 C C   . LYS A 1 297 ? 166.234 246.737 344.396 1.00 84.74  ? 297 LYS A C   1 
ATOM   2137 O O   . LYS A 1 297 ? 166.634 245.569 344.396 1.00 83.73  ? 297 LYS A O   1 
ATOM   2138 C CB  . LYS A 1 297 ? 167.903 247.824 342.870 1.00 83.81  ? 297 LYS A CB  1 
ATOM   2139 C CG  . LYS A 1 297 ? 166.962 248.003 341.689 1.00 82.44  ? 297 LYS A CG  1 
ATOM   2140 C CD  . LYS A 1 297 ? 166.372 249.404 341.651 1.00 82.66  ? 297 LYS A CD  1 
ATOM   2141 C CE  . LYS A 1 297 ? 165.584 249.646 340.375 1.00 83.73  ? 297 LYS A CE  1 
ATOM   2142 N NZ  . LYS A 1 297 ? 166.453 249.631 339.166 1.00 83.48  ? 297 LYS A NZ  1 
ATOM   2143 N N   . ASP A 1 298 ? 164.948 247.050 344.519 1.00 86.94  ? 298 ASP A N   1 
ATOM   2144 C CA  . ASP A 1 298 ? 163.948 246.008 344.707 1.00 86.69  ? 298 ASP A CA  1 
ATOM   2145 C C   . ASP A 1 298 ? 163.892 245.097 343.487 1.00 86.47  ? 298 ASP A C   1 
ATOM   2146 O O   . ASP A 1 298 ? 164.132 245.521 342.354 1.00 86.57  ? 298 ASP A O   1 
ATOM   2147 C CB  . ASP A 1 298 ? 162.578 246.630 344.967 1.00 91.97  ? 298 ASP A CB  1 
ATOM   2148 C CG  . ASP A 1 298 ? 162.552 247.473 346.227 1.00 95.23  ? 298 ASP A CG  1 
ATOM   2149 O OD1 . ASP A 1 298 ? 163.584 247.525 346.930 1.00 94.93  ? 298 ASP A OD1 1 
ATOM   2150 O OD2 . ASP A 1 298 ? 161.502 248.085 346.515 1.00 91.76  ? 298 ASP A OD2 1 
ATOM   2151 N N   . LEU A 1 299 ? 163.576 243.824 343.731 1.00 85.29  ? 299 LEU A N   1 
ATOM   2152 C CA  . LEU A 1 299 ? 163.586 242.839 342.654 1.00 82.73  ? 299 LEU A CA  1 
ATOM   2153 C C   . LEU A 1 299 ? 162.614 243.224 341.546 1.00 84.28  ? 299 LEU A C   1 
ATOM   2154 O O   . LEU A 1 299 ? 162.964 243.194 340.361 1.00 90.17  ? 299 LEU A O   1 
ATOM   2155 C CB  . LEU A 1 299 ? 163.248 241.454 343.208 1.00 82.68  ? 299 LEU A CB  1 
ATOM   2156 C CG  . LEU A 1 299 ? 163.042 240.349 342.168 1.00 84.24  ? 299 LEU A CG  1 
ATOM   2157 C CD1 . LEU A 1 299 ? 164.232 240.260 341.228 1.00 82.94  ? 299 LEU A CD1 1 
ATOM   2158 C CD2 . LEU A 1 299 ? 162.798 239.012 342.846 1.00 80.08  ? 299 LEU A CD2 1 
ATOM   2159 N N   . THR A 1 300 ? 161.388 243.588 341.912 1.00 78.84  ? 300 THR A N   1 
ATOM   2160 C CA  . THR A 1 300 ? 160.355 243.957 340.945 1.00 79.00  ? 300 THR A CA  1 
ATOM   2161 C C   . THR A 1 300 ? 160.204 245.474 340.976 1.00 80.92  ? 300 THR A C   1 
ATOM   2162 O O   . THR A 1 300 ? 159.294 246.016 341.603 1.00 84.43  ? 300 THR A O   1 
ATOM   2163 C CB  . THR A 1 300 ? 159.040 243.255 341.261 1.00 78.94  ? 300 THR A CB  1 
ATOM   2164 O OG1 . THR A 1 300 ? 158.656 243.541 342.611 1.00 81.03  ? 300 THR A OG1 1 
ATOM   2165 C CG2 . THR A 1 300 ? 159.183 241.753 341.087 1.00 79.44  ? 300 THR A CG2 1 
ATOM   2166 N N   . THR A 1 301 ? 161.109 246.163 340.284 1.00 75.04  ? 301 THR A N   1 
ATOM   2167 C CA  . THR A 1 301 ? 161.060 247.616 340.197 1.00 76.55  ? 301 THR A CA  1 
ATOM   2168 C C   . THR A 1 301 ? 161.855 248.099 338.993 1.00 78.10  ? 301 THR A C   1 
ATOM   2169 O O   . THR A 1 301 ? 163.074 247.914 338.932 1.00 83.54  ? 301 THR A O   1 
ATOM   2170 C CB  . THR A 1 301 ? 161.604 248.254 341.475 1.00 79.55  ? 301 THR A CB  1 
ATOM   2171 O OG1 . THR A 1 301 ? 160.743 247.936 342.575 1.00 85.23  ? 301 THR A OG1 1 
ATOM   2172 C CG2 . THR A 1 301 ? 161.694 249.767 341.323 1.00 77.78  ? 301 THR A CG2 1 
ATOM   2173 N N   . TYR A 1 302 ? 161.177 248.723 338.038 1.00 68.80  ? 302 TYR A N   1 
ATOM   2174 C CA  . TYR A 1 302 ? 161.836 249.220 336.839 1.00 68.07  ? 302 TYR A CA  1 
ATOM   2175 C C   . TYR A 1 302 ? 162.661 250.463 337.151 1.00 68.71  ? 302 TYR A C   1 
ATOM   2176 O O   . TYR A 1 302 ? 163.485 250.459 338.065 1.00 68.86  ? 302 TYR A O   1 
ATOM   2177 C CB  . TYR A 1 302 ? 160.806 249.534 335.755 1.00 68.03  ? 302 TYR A CB  1 
ATOM   2178 C CG  . TYR A 1 302 ? 159.993 248.339 335.315 1.00 66.40  ? 302 TYR A CG  1 
ATOM   2179 C CD1 . TYR A 1 302 ? 160.459 247.484 334.329 1.00 65.45  ? 302 TYR A CD1 1 
ATOM   2180 C CD2 . TYR A 1 302 ? 158.757 248.069 335.881 1.00 68.84  ? 302 TYR A CD2 1 
ATOM   2181 C CE1 . TYR A 1 302 ? 159.720 246.394 333.922 1.00 66.15  ? 302 TYR A CE1 1 
ATOM   2182 C CE2 . TYR A 1 302 ? 158.012 246.979 335.479 1.00 69.81  ? 302 TYR A CE2 1 
ATOM   2183 C CZ  . TYR A 1 302 ? 158.499 246.147 334.498 1.00 68.58  ? 302 TYR A CZ  1 
ATOM   2184 O OH  . TYR A 1 302 ? 157.763 245.060 334.091 1.00 71.87  ? 302 TYR A OH  1 
ATOM   2185 N N   . GLN B 2 4   ? 205.107 256.785 303.452 1.00 102.11 ? 4   GLN B N   1 
ATOM   2186 C CA  . GLN B 2 4   ? 203.962 255.883 303.387 1.00 106.68 ? 4   GLN B CA  1 
ATOM   2187 C C   . GLN B 2 4   ? 202.660 256.647 303.600 1.00 105.38 ? 4   GLN B C   1 
ATOM   2188 O O   . GLN B 2 4   ? 202.374 257.112 304.703 1.00 105.24 ? 4   GLN B O   1 
ATOM   2189 C CB  . GLN B 2 4   ? 204.102 254.768 304.428 1.00 105.32 ? 4   GLN B CB  1 
ATOM   2190 C CG  . GLN B 2 4   ? 202.878 253.864 304.577 1.00 105.74 ? 4   GLN B CG  1 
ATOM   2191 C CD  . GLN B 2 4   ? 202.558 253.073 303.321 1.00 105.44 ? 4   GLN B CD  1 
ATOM   2192 O OE1 . GLN B 2 4   ? 203.096 253.338 302.247 1.00 105.65 ? 4   GLN B OE1 1 
ATOM   2193 N NE2 . GLN B 2 4   ? 201.678 252.087 303.454 1.00 103.45 ? 4   GLN B NE2 1 
ATOM   2194 N N   . VAL B 2 5   ? 201.872 256.767 302.535 1.00 103.48 ? 5   VAL B N   1 
ATOM   2195 C CA  . VAL B 2 5   ? 200.598 257.478 302.578 1.00 104.18 ? 5   VAL B CA  1 
ATOM   2196 C C   . VAL B 2 5   ? 199.523 256.453 302.926 1.00 105.15 ? 5   VAL B C   1 
ATOM   2197 O O   . VAL B 2 5   ? 199.066 255.695 302.069 1.00 104.16 ? 5   VAL B O   1 
ATOM   2198 C CB  . VAL B 2 5   ? 200.302 258.185 301.255 1.00 104.63 ? 5   VAL B CB  1 
ATOM   2199 C CG1 . VAL B 2 5   ? 199.000 258.966 301.348 1.00 103.50 ? 5   VAL B CG1 1 
ATOM   2200 C CG2 . VAL B 2 5   ? 201.454 259.102 300.875 1.00 102.97 ? 5   VAL B CG2 1 
ATOM   2201 N N   . SER B 2 6   ? 199.115 256.433 304.190 1.00 105.16 ? 6   SER B N   1 
ATOM   2202 C CA  . SER B 2 6   ? 198.089 255.513 304.655 1.00 103.72 ? 6   SER B CA  1 
ATOM   2203 C C   . SER B 2 6   ? 196.707 256.136 304.500 1.00 103.86 ? 6   SER B C   1 
ATOM   2204 O O   . SER B 2 6   ? 196.549 257.360 304.506 1.00 103.64 ? 6   SER B O   1 
ATOM   2205 C CB  . SER B 2 6   ? 198.326 255.130 306.117 1.00 103.84 ? 6   SER B CB  1 
ATOM   2206 O OG  . SER B 2 6   ? 199.546 254.424 306.268 1.00 101.69 ? 6   SER B OG  1 
ATOM   2207 N N   . SER B 2 7   ? 195.704 255.276 304.360 1.00 98.34  ? 7   SER B N   1 
ATOM   2208 C CA  . SER B 2 7   ? 194.337 255.727 304.164 1.00 97.37  ? 7   SER B CA  1 
ATOM   2209 C C   . SER B 2 7   ? 193.699 256.110 305.495 1.00 95.98  ? 7   SER B C   1 
ATOM   2210 O O   . SER B 2 7   ? 194.136 255.693 306.571 1.00 95.41  ? 7   SER B O   1 
ATOM   2211 C CB  . SER B 2 7   ? 193.507 254.640 303.482 1.00 95.28  ? 7   SER B CB  1 
ATOM   2212 O OG  . SER B 2 7   ? 194.104 254.230 302.265 1.00 95.48  ? 7   SER B OG  1 
ATOM   2213 N N   . GLN B 2 8   ? 192.647 256.919 305.408 1.00 88.21  ? 8   GLN B N   1 
ATOM   2214 C CA  . GLN B 2 8   ? 191.892 257.333 306.584 1.00 87.18  ? 8   GLN B CA  1 
ATOM   2215 C C   . GLN B 2 8   ? 190.541 256.631 306.617 1.00 85.07  ? 8   GLN B C   1 
ATOM   2216 O O   . GLN B 2 8   ? 190.031 256.200 305.583 1.00 84.06  ? 8   GLN B O   1 
ATOM   2217 C CB  . GLN B 2 8   ? 191.697 258.850 306.596 1.00 85.39  ? 8   GLN B CB  1 
ATOM   2218 C CG  . GLN B 2 8   ? 192.984 259.641 306.735 1.00 85.61  ? 8   GLN B CG  1 
ATOM   2219 C CD  . GLN B 2 8   ? 192.742 261.135 306.805 1.00 86.38  ? 8   GLN B CD  1 
ATOM   2220 O OE1 . GLN B 2 8   ? 191.753 261.640 306.277 1.00 88.50  ? 8   GLN B OE1 1 
ATOM   2221 N NE2 . GLN B 2 8   ? 193.645 261.850 307.465 1.00 84.48  ? 8   GLN B NE2 1 
ATOM   2222 N N   . THR B 2 28  ? 200.291 260.797 305.640 1.00 89.91  ? 28  THR B N   1 
ATOM   2223 C CA  . THR B 2 28  ? 201.718 260.624 305.403 1.00 95.90  ? 28  THR B CA  1 
ATOM   2224 C C   . THR B 2 28  ? 202.419 260.195 306.688 1.00 95.76  ? 28  THR B C   1 
ATOM   2225 O O   . THR B 2 28  ? 202.691 261.017 307.562 1.00 93.24  ? 28  THR B O   1 
ATOM   2226 C CB  . THR B 2 28  ? 202.361 261.919 304.873 1.00 94.04  ? 28  THR B CB  1 
ATOM   2227 O OG1 . THR B 2 28  ? 201.626 262.391 303.738 1.00 93.27  ? 28  THR B OG1 1 
ATOM   2228 C CG2 . THR B 2 28  ? 203.806 261.675 304.467 1.00 90.38  ? 28  THR B CG2 1 
ATOM   2229 N N   . THR B 2 29  ? 202.712 258.901 306.792 1.00 104.57 ? 29  THR B N   1 
ATOM   2230 C CA  . THR B 2 29  ? 203.324 258.319 307.985 1.00 105.37 ? 29  THR B CA  1 
ATOM   2231 C C   . THR B 2 29  ? 204.796 258.053 307.687 1.00 103.05 ? 29  THR B C   1 
ATOM   2232 O O   . THR B 2 29  ? 205.135 257.111 306.967 1.00 101.08 ? 29  THR B O   1 
ATOM   2233 C CB  . THR B 2 29  ? 202.598 257.041 308.395 1.00 104.56 ? 29  THR B CB  1 
ATOM   2234 O OG1 . THR B 2 29  ? 201.239 257.346 308.733 1.00 104.49 ? 29  THR B OG1 1 
ATOM   2235 C CG2 . THR B 2 29  ? 203.281 256.392 309.591 1.00 100.25 ? 29  THR B CG2 1 
ATOM   2236 N N   . ILE B 2 30  ? 205.668 258.884 308.252 1.00 99.29  ? 30  ILE B N   1 
ATOM   2237 C CA  . ILE B 2 30  ? 207.112 258.757 308.100 1.00 99.01  ? 30  ILE B CA  1 
ATOM   2238 C C   . ILE B 2 30  ? 207.708 258.463 309.469 1.00 97.83  ? 30  ILE B C   1 
ATOM   2239 O O   . ILE B 2 30  ? 207.401 259.153 310.448 1.00 96.32  ? 30  ILE B O   1 
ATOM   2240 C CB  . ILE B 2 30  ? 207.732 260.030 307.495 1.00 96.88  ? 30  ILE B CB  1 
ATOM   2241 C CG1 . ILE B 2 30  ? 207.262 260.228 306.051 1.00 96.44  ? 30  ILE B CG1 1 
ATOM   2242 C CG2 . ILE B 2 30  ? 209.250 259.963 307.553 1.00 96.73  ? 30  ILE B CG2 1 
ATOM   2243 C CD1 . ILE B 2 30  ? 207.889 259.275 305.054 1.00 94.35  ? 30  ILE B CD1 1 
ATOM   2244 N N   . ASN B 2 31  ? 208.555 257.439 309.537 1.00 97.48  ? 31  ASN B N   1 
ATOM   2245 C CA  . ASN B 2 31  ? 209.236 257.071 310.772 1.00 97.96  ? 31  ASN B CA  1 
ATOM   2246 C C   . ASN B 2 31  ? 210.610 257.730 310.797 1.00 97.98  ? 31  ASN B C   1 
ATOM   2247 O O   . ASN B 2 31  ? 211.422 257.518 309.890 1.00 96.40  ? 31  ASN B O   1 
ATOM   2248 C CB  . ASN B 2 31  ? 209.363 255.553 310.887 1.00 96.48  ? 31  ASN B CB  1 
ATOM   2249 C CG  . ASN B 2 31  ? 208.029 254.871 311.117 1.00 95.89  ? 31  ASN B CG  1 
ATOM   2250 O OD1 . ASN B 2 31  ? 207.162 255.397 311.814 1.00 95.28  ? 31  ASN B OD1 1 
ATOM   2251 N ND2 . ASN B 2 31  ? 207.858 253.694 310.529 1.00 95.19  ? 31  ASN B ND2 1 
ATOM   2252 N N   . TYR B 2 32  ? 210.868 258.523 311.837 1.00 96.29  ? 32  TYR B N   1 
ATOM   2253 C CA  . TYR B 2 32  ? 212.108 259.278 311.950 1.00 93.13  ? 32  TYR B CA  1 
ATOM   2254 C C   . TYR B 2 32  ? 213.104 258.661 312.920 1.00 95.46  ? 32  TYR B C   1 
ATOM   2255 O O   . TYR B 2 32  ? 214.278 259.046 312.900 1.00 96.84  ? 32  TYR B O   1 
ATOM   2256 C CB  . TYR B 2 32  ? 211.814 260.716 312.394 1.00 91.51  ? 32  TYR B CB  1 
ATOM   2257 C CG  . TYR B 2 32  ? 210.887 261.465 311.468 1.00 93.92  ? 32  TYR B CG  1 
ATOM   2258 C CD1 . TYR B 2 32  ? 211.303 261.850 310.202 1.00 94.06  ? 32  TYR B CD1 1 
ATOM   2259 C CD2 . TYR B 2 32  ? 209.598 261.794 311.863 1.00 93.21  ? 32  TYR B CD2 1 
ATOM   2260 C CE1 . TYR B 2 32  ? 210.461 262.535 309.353 1.00 96.29  ? 32  TYR B CE1 1 
ATOM   2261 C CE2 . TYR B 2 32  ? 208.748 262.480 311.020 1.00 95.54  ? 32  TYR B CE2 1 
ATOM   2262 C CZ  . TYR B 2 32  ? 209.185 262.848 309.765 1.00 98.50  ? 32  TYR B CZ  1 
ATOM   2263 O OH  . TYR B 2 32  ? 208.342 263.533 308.919 1.00 99.24  ? 32  TYR B OH  1 
ATOM   2264 N N   . TYR B 2 33  ? 212.676 257.724 313.759 1.00 97.50  ? 33  TYR B N   1 
ATOM   2265 C CA  . TYR B 2 33  ? 213.512 257.166 314.813 1.00 98.00  ? 33  TYR B CA  1 
ATOM   2266 C C   . TYR B 2 33  ? 213.778 255.695 314.535 1.00 98.41  ? 33  TYR B C   1 
ATOM   2267 O O   . TYR B 2 33  ? 212.855 254.941 314.211 1.00 99.06  ? 33  TYR B O   1 
ATOM   2268 C CB  . TYR B 2 33  ? 212.848 257.345 316.177 1.00 97.18  ? 33  TYR B CB  1 
ATOM   2269 C CG  . TYR B 2 33  ? 212.573 258.790 316.513 1.00 96.89  ? 33  TYR B CG  1 
ATOM   2270 C CD1 . TYR B 2 33  ? 213.586 259.622 316.967 1.00 94.98  ? 33  TYR B CD1 1 
ATOM   2271 C CD2 . TYR B 2 33  ? 211.302 259.326 316.369 1.00 97.04  ? 33  TYR B CD2 1 
ATOM   2272 C CE1 . TYR B 2 33  ? 213.341 260.944 317.271 1.00 95.35  ? 33  TYR B CE1 1 
ATOM   2273 C CE2 . TYR B 2 33  ? 211.048 260.647 316.673 1.00 97.43  ? 33  TYR B CE2 1 
ATOM   2274 C CZ  . TYR B 2 33  ? 212.070 261.452 317.123 1.00 97.03  ? 33  TYR B CZ  1 
ATOM   2275 O OH  . TYR B 2 33  ? 211.818 262.769 317.426 1.00 98.78  ? 33  TYR B OH  1 
ATOM   2276 N N   . ARG B 2 34  ? 215.044 255.293 314.669 1.00 100.77 ? 34  ARG B N   1 
ATOM   2277 C CA  . ARG B 2 34  ? 215.429 253.923 314.349 1.00 102.43 ? 34  ARG B CA  1 
ATOM   2278 C C   . ARG B 2 34  ? 214.706 252.918 315.235 1.00 102.88 ? 34  ARG B C   1 
ATOM   2279 O O   . ARG B 2 34  ? 214.237 251.880 314.755 1.00 100.67 ? 34  ARG B O   1 
ATOM   2280 C CB  . ARG B 2 34  ? 216.943 253.767 314.487 1.00 101.56 ? 34  ARG B CB  1 
ATOM   2281 C CG  . ARG B 2 34  ? 217.395 252.345 314.765 1.00 102.81 ? 34  ARG B CG  1 
ATOM   2282 C CD  . ARG B 2 34  ? 218.896 252.186 314.614 1.00 100.69 ? 34  ARG B CD  1 
ATOM   2283 N NE  . ARG B 2 34  ? 219.330 250.859 315.033 1.00 102.48 ? 34  ARG B NE  1 
ATOM   2284 C CZ  . ARG B 2 34  ? 219.129 249.750 314.334 1.00 101.53 ? 34  ARG B CZ  1 
ATOM   2285 N NH1 . ARG B 2 34  ? 218.503 249.771 313.169 1.00 99.84  ? 34  ARG B NH1 1 
ATOM   2286 N NH2 . ARG B 2 34  ? 219.562 248.591 314.820 1.00 102.04 ? 34  ARG B NH2 1 
ATOM   2287 N N   . ASP B 2 35  ? 214.611 253.202 316.530 1.00 105.14 ? 35  ASP B N   1 
ATOM   2288 C CA  . ASP B 2 35  ? 214.013 252.256 317.459 1.00 103.51 ? 35  ASP B CA  1 
ATOM   2289 C C   . ASP B 2 35  ? 212.510 252.146 317.227 1.00 102.51 ? 35  ASP B C   1 
ATOM   2290 O O   . ASP B 2 35  ? 211.828 253.143 316.976 1.00 101.70 ? 35  ASP B O   1 
ATOM   2291 C CB  . ASP B 2 35  ? 214.303 252.686 318.894 1.00 104.06 ? 35  ASP B CB  1 
ATOM   2292 C CG  . ASP B 2 35  ? 215.787 252.835 319.161 1.00 105.50 ? 35  ASP B CG  1 
ATOM   2293 O OD1 . ASP B 2 35  ? 216.557 251.941 318.754 1.00 103.10 ? 35  ASP B OD1 1 
ATOM   2294 O OD2 . ASP B 2 35  ? 216.187 253.852 319.762 1.00 105.74 ? 35  ASP B OD2 1 
ATOM   2295 N N   . SER B 2 36  ? 211.996 250.917 317.317 1.00 94.92  ? 36  SER B N   1 
ATOM   2296 C CA  . SER B 2 36  ? 210.586 250.676 317.027 1.00 92.93  ? 36  SER B CA  1 
ATOM   2297 C C   . SER B 2 36  ? 209.675 251.292 318.080 1.00 92.44  ? 36  SER B C   1 
ATOM   2298 O O   . SER B 2 36  ? 208.569 251.736 317.755 1.00 93.38  ? 36  SER B O   1 
ATOM   2299 C CB  . SER B 2 36  ? 210.324 249.175 316.920 1.00 92.93  ? 36  SER B CB  1 
ATOM   2300 O OG  . SER B 2 36  ? 210.640 248.516 318.134 1.00 93.54  ? 36  SER B OG  1 
ATOM   2301 N N   . ALA B 2 37  ? 210.111 251.324 319.341 1.00 91.35  ? 37  ALA B N   1 
ATOM   2302 C CA  . ALA B 2 37  ? 209.284 251.897 320.396 1.00 88.83  ? 37  ALA B CA  1 
ATOM   2303 C C   . ALA B 2 37  ? 208.953 253.358 320.139 1.00 92.62  ? 37  ALA B C   1 
ATOM   2304 O O   . ALA B 2 37  ? 207.960 253.861 320.676 1.00 90.30  ? 37  ALA B O   1 
ATOM   2305 C CB  . ALA B 2 37  ? 209.988 251.764 321.744 1.00 91.29  ? 37  ALA B CB  1 
ATOM   2306 N N   . SER B 2 38  ? 209.761 254.051 319.337 1.00 99.19  ? 38  SER B N   1 
ATOM   2307 C CA  . SER B 2 38  ? 209.533 255.458 319.045 1.00 97.15  ? 38  SER B CA  1 
ATOM   2308 C C   . SER B 2 38  ? 208.440 255.684 318.009 1.00 96.42  ? 38  SER B C   1 
ATOM   2309 O O   . SER B 2 38  ? 208.019 256.830 317.821 1.00 100.48 ? 38  SER B O   1 
ATOM   2310 C CB  . SER B 2 38  ? 210.830 256.104 318.560 1.00 97.08  ? 38  SER B CB  1 
ATOM   2311 O OG  . SER B 2 38  ? 211.795 256.143 319.595 1.00 97.97  ? 38  SER B OG  1 
ATOM   2312 N N   . ASN B 2 39  ? 207.974 254.637 317.337 1.00 86.64  ? 39  ASN B N   1 
ATOM   2313 C CA  . ASN B 2 39  ? 206.921 254.801 316.349 1.00 86.13  ? 39  ASN B CA  1 
ATOM   2314 C C   . ASN B 2 39  ? 205.611 255.197 317.022 1.00 86.84  ? 39  ASN B C   1 
ATOM   2315 O O   . ASN B 2 39  ? 205.420 255.029 318.229 1.00 85.94  ? 39  ASN B O   1 
ATOM   2316 C CB  . ASN B 2 39  ? 206.722 253.513 315.553 1.00 88.07  ? 39  ASN B CB  1 
ATOM   2317 C CG  . ASN B 2 39  ? 207.840 253.258 314.567 1.00 89.27  ? 39  ASN B CG  1 
ATOM   2318 O OD1 . ASN B 2 39  ? 208.523 254.184 314.131 1.00 90.45  ? 39  ASN B OD1 1 
ATOM   2319 N ND2 . ASN B 2 39  ? 208.028 251.996 314.202 1.00 89.53  ? 39  ASN B ND2 1 
ATOM   2320 N N   . ALA B 2 40  ? 204.703 255.741 316.217 1.00 82.30  ? 40  ALA B N   1 
ATOM   2321 C CA  . ALA B 2 40  ? 203.375 256.082 316.693 1.00 83.05  ? 40  ALA B CA  1 
ATOM   2322 C C   . ALA B 2 40  ? 202.474 254.850 316.670 1.00 84.40  ? 40  ALA B C   1 
ATOM   2323 O O   . ALA B 2 40  ? 202.795 253.819 316.074 1.00 83.00  ? 40  ALA B O   1 
ATOM   2324 C CB  . ALA B 2 40  ? 202.773 257.199 315.842 1.00 79.93  ? 40  ALA B CB  1 
ATOM   2325 N N   . ALA B 2 41  ? 201.330 254.966 317.335 1.00 79.79  ? 41  ALA B N   1 
ATOM   2326 C CA  . ALA B 2 41  ? 200.373 253.870 317.395 1.00 78.00  ? 41  ALA B CA  1 
ATOM   2327 C C   . ALA B 2 41  ? 199.676 253.692 316.050 1.00 77.36  ? 41  ALA B C   1 
ATOM   2328 O O   . ALA B 2 41  ? 198.529 254.101 315.874 1.00 77.33  ? 41  ALA B O   1 
ATOM   2329 C CB  . ALA B 2 41  ? 199.354 254.117 318.493 1.00 76.92  ? 41  ALA B CB  1 
ATOM   2330 N N   . ASP B 2 80  ? 176.252 214.845 323.238 1.00 78.59  ? 80  ASP B N   1 
ATOM   2331 C CA  . ASP B 2 80  ? 177.120 215.671 324.067 1.00 83.99  ? 80  ASP B CA  1 
ATOM   2332 C C   . ASP B 2 80  ? 177.197 215.117 325.483 1.00 82.27  ? 80  ASP B C   1 
ATOM   2333 O O   . ASP B 2 80  ? 178.227 215.228 326.146 1.00 80.62  ? 80  ASP B O   1 
ATOM   2334 C CB  . ASP B 2 80  ? 176.618 217.114 324.101 1.00 79.24  ? 80  ASP B CB  1 
ATOM   2335 C CG  . ASP B 2 80  ? 175.314 217.258 324.857 1.00 79.20  ? 80  ASP B CG  1 
ATOM   2336 O OD1 . ASP B 2 80  ? 174.507 216.306 324.835 1.00 79.88  ? 80  ASP B OD1 1 
ATOM   2337 O OD2 . ASP B 2 80  ? 175.097 218.319 325.477 1.00 79.86  ? 80  ASP B OD2 1 
ATOM   2338 N N   . ARG B 2 81  ? 176.097 214.511 325.937 1.00 81.93  ? 81  ARG B N   1 
ATOM   2339 C CA  . ARG B 2 81  ? 176.049 213.986 327.297 1.00 81.55  ? 81  ARG B CA  1 
ATOM   2340 C C   . ARG B 2 81  ? 177.142 212.954 327.529 1.00 78.25  ? 81  ARG B C   1 
ATOM   2341 O O   . ARG B 2 81  ? 177.770 212.929 328.594 1.00 74.44  ? 81  ARG B O   1 
ATOM   2342 C CB  . ARG B 2 81  ? 174.680 213.365 327.571 1.00 78.40  ? 81  ARG B CB  1 
ATOM   2343 C CG  . ARG B 2 81  ? 173.525 214.335 327.496 1.00 78.87  ? 81  ARG B CG  1 
ATOM   2344 C CD  . ARG B 2 81  ? 172.286 213.754 328.153 1.00 80.65  ? 81  ARG B CD  1 
ATOM   2345 N NE  . ARG B 2 81  ? 171.150 214.664 328.076 1.00 86.53  ? 81  ARG B NE  1 
ATOM   2346 C CZ  . ARG B 2 81  ? 171.015 215.756 328.817 1.00 87.40  ? 81  ARG B CZ  1 
ATOM   2347 N NH1 . ARG B 2 81  ? 171.938 216.117 329.694 1.00 86.88  ? 81  ARG B NH1 1 
ATOM   2348 N NH2 . ARG B 2 81  ? 169.929 216.509 328.669 1.00 82.10  ? 81  ARG B NH2 1 
ATOM   2349 N N   . VAL B 2 82  ? 177.384 212.100 326.545 1.00 71.25  ? 82  VAL B N   1 
ATOM   2350 C CA  . VAL B 2 82  ? 178.257 210.948 326.722 1.00 70.58  ? 82  VAL B CA  1 
ATOM   2351 C C   . VAL B 2 82  ? 179.704 211.367 326.513 1.00 71.33  ? 82  VAL B C   1 
ATOM   2352 O O   . VAL B 2 82  ? 180.023 212.128 325.591 1.00 66.85  ? 82  VAL B O   1 
ATOM   2353 C CB  . VAL B 2 82  ? 177.856 209.823 325.754 1.00 68.35  ? 82  VAL B CB  1 
ATOM   2354 C CG1 . VAL B 2 82  ? 178.402 208.509 326.235 1.00 66.26  ? 82  VAL B CG1 1 
ATOM   2355 C CG2 . VAL B 2 82  ? 176.344 209.750 325.618 1.00 70.04  ? 82  VAL B CG2 1 
ATOM   2356 N N   . LEU B 2 83  ? 180.588 210.868 327.374 1.00 71.41  ? 83  LEU B N   1 
ATOM   2357 C CA  . LEU B 2 83  ? 182.001 211.208 327.311 1.00 66.29  ? 83  LEU B CA  1 
ATOM   2358 C C   . LEU B 2 83  ? 182.820 210.065 327.892 1.00 66.22  ? 83  LEU B C   1 
ATOM   2359 O O   . LEU B 2 83  ? 182.437 209.469 328.902 1.00 67.99  ? 83  LEU B O   1 
ATOM   2360 C CB  . LEU B 2 83  ? 182.289 212.505 328.075 1.00 65.74  ? 83  LEU B CB  1 
ATOM   2361 C CG  . LEU B 2 83  ? 183.685 213.105 327.912 1.00 71.23  ? 83  LEU B CG  1 
ATOM   2362 C CD1 . LEU B 2 83  ? 183.903 213.590 326.489 1.00 68.92  ? 83  LEU B CD1 1 
ATOM   2363 C CD2 . LEU B 2 83  ? 183.882 214.238 328.898 1.00 67.54  ? 83  LEU B CD2 1 
ATOM   2364 N N   . GLN B 2 84  ? 183.946 209.766 327.247 1.00 65.44  ? 84  GLN B N   1 
ATOM   2365 C CA  . GLN B 2 84  ? 184.904 208.795 327.766 1.00 68.41  ? 84  GLN B CA  1 
ATOM   2366 C C   . GLN B 2 84  ? 186.281 209.182 327.256 1.00 65.30  ? 84  GLN B C   1 
ATOM   2367 O O   . GLN B 2 84  ? 186.490 209.275 326.043 1.00 66.56  ? 84  GLN B O   1 
ATOM   2368 C CB  . GLN B 2 84  ? 184.548 207.369 327.341 1.00 66.88  ? 84  GLN B CB  1 
ATOM   2369 C CG  . GLN B 2 84  ? 185.472 206.291 327.894 1.00 69.03  ? 84  GLN B CG  1 
ATOM   2370 C CD  . GLN B 2 84  ? 186.592 205.923 326.942 1.00 66.91  ? 84  GLN B CD  1 
ATOM   2371 O OE1 . GLN B 2 84  ? 186.885 206.652 325.995 1.00 66.99  ? 84  GLN B OE1 1 
ATOM   2372 N NE2 . GLN B 2 84  ? 187.220 204.779 327.186 1.00 63.38  ? 84  GLN B NE2 1 
ATOM   2373 N N   . LEU B 2 85  ? 187.211 209.404 328.181 1.00 58.08  ? 85  LEU B N   1 
ATOM   2374 C CA  . LEU B 2 85  ? 188.533 209.914 327.849 1.00 59.48  ? 85  LEU B CA  1 
ATOM   2375 C C   . LEU B 2 85  ? 189.594 209.124 328.602 1.00 57.77  ? 85  LEU B C   1 
ATOM   2376 O O   . LEU B 2 85  ? 189.455 208.868 329.801 1.00 53.52  ? 85  LEU B O   1 
ATOM   2377 C CB  . LEU B 2 85  ? 188.635 211.412 328.175 1.00 60.46  ? 85  LEU B CB  1 
ATOM   2378 C CG  . LEU B 2 85  ? 187.984 211.892 329.479 1.00 62.09  ? 85  LEU B CG  1 
ATOM   2379 C CD1 . LEU B 2 85  ? 188.973 211.845 330.620 1.00 59.93  ? 85  LEU B CD1 1 
ATOM   2380 C CD2 . LEU B 2 85  ? 187.416 213.291 329.324 1.00 52.08  ? 85  LEU B CD2 1 
ATOM   2381 N N   . THR B 2 86  ? 190.652 208.740 327.891 1.00 63.86  ? 86  THR B N   1 
ATOM   2382 C CA  . THR B 2 86  ? 191.711 207.899 328.436 1.00 60.19  ? 86  THR B CA  1 
ATOM   2383 C C   . THR B 2 86  ? 193.042 208.637 328.395 1.00 59.13  ? 86  THR B C   1 
ATOM   2384 O O   . THR B 2 86  ? 193.459 209.119 327.337 1.00 58.04  ? 86  THR B O   1 
ATOM   2385 C CB  . THR B 2 86  ? 191.822 206.587 327.655 1.00 60.97  ? 86  THR B CB  1 
ATOM   2386 O OG1 . THR B 2 86  ? 190.556 205.916 327.658 1.00 59.47  ? 86  THR B OG1 1 
ATOM   2387 C CG2 . THR B 2 86  ? 192.871 205.680 328.276 1.00 60.94  ? 86  THR B CG2 1 
ATOM   2388 N N   . LEU B 2 87  ? 193.715 208.694 329.545 1.00 59.15  ? 87  LEU B N   1 
ATOM   2389 C CA  . LEU B 2 87  ? 195.041 209.299 329.694 1.00 59.03  ? 87  LEU B CA  1 
ATOM   2390 C C   . LEU B 2 87  ? 195.925 208.250 330.360 1.00 56.50  ? 87  LEU B C   1 
ATOM   2391 O O   . LEU B 2 87  ? 195.725 207.904 331.528 1.00 59.45  ? 87  LEU B O   1 
ATOM   2392 C CB  . LEU B 2 87  ? 194.994 210.592 330.506 1.00 58.54  ? 87  LEU B CB  1 
ATOM   2393 C CG  . LEU B 2 87  ? 194.999 211.909 329.727 1.00 59.53  ? 87  LEU B CG  1 
ATOM   2394 C CD1 . LEU B 2 87  ? 196.332 212.113 329.023 1.00 58.43  ? 87  LEU B CD1 1 
ATOM   2395 C CD2 . LEU B 2 87  ? 193.847 211.958 328.734 1.00 57.56  ? 87  LEU B CD2 1 
ATOM   2396 N N   . GLY B 2 88  ? 196.866 207.709 329.600 1.00 59.61  ? 88  GLY B N   1 
ATOM   2397 C CA  . GLY B 2 88  ? 197.795 206.745 330.163 1.00 58.68  ? 88  GLY B CA  1 
ATOM   2398 C C   . GLY B 2 88  ? 197.067 205.480 330.524 1.00 57.95  ? 88  GLY B C   1 
ATOM   2399 O O   . GLY B 2 88  ? 196.358 204.897 329.700 1.00 59.63  ? 88  GLY B O   1 
ATOM   2400 N N   . ASN B 2 89  ? 197.235 205.045 331.765 1.00 62.56  ? 89  ASN B N   1 
ATOM   2401 C CA  . ASN B 2 89  ? 196.544 203.870 332.269 1.00 62.63  ? 89  ASN B CA  1 
ATOM   2402 C C   . ASN B 2 89  ? 195.217 204.208 332.932 1.00 59.26  ? 89  ASN B C   1 
ATOM   2403 O O   . ASN B 2 89  ? 194.581 203.318 333.504 1.00 66.47  ? 89  ASN B O   1 
ATOM   2404 C CB  . ASN B 2 89  ? 197.444 203.119 333.250 1.00 66.17  ? 89  ASN B CB  1 
ATOM   2405 C CG  . ASN B 2 89  ? 197.953 204.002 334.374 1.00 59.68  ? 89  ASN B CG  1 
ATOM   2406 O OD1 . ASN B 2 89  ? 198.705 204.945 334.142 1.00 61.17  ? 89  ASN B OD1 1 
ATOM   2407 N ND2 . ASN B 2 89  ? 197.555 203.690 335.600 1.00 57.00  ? 89  ASN B ND2 1 
ATOM   2408 N N   . SER B 2 90  ? 194.783 205.463 332.866 1.00 53.19  ? 90  SER B N   1 
ATOM   2409 C CA  . SER B 2 90  ? 193.566 205.913 333.522 1.00 58.44  ? 90  SER B CA  1 
ATOM   2410 C C   . SER B 2 90  ? 192.489 206.192 332.485 1.00 56.67  ? 90  SER B C   1 
ATOM   2411 O O   . SER B 2 90  ? 192.773 206.720 331.407 1.00 59.45  ? 90  SER B O   1 
ATOM   2412 C CB  . SER B 2 90  ? 193.834 207.170 334.350 1.00 64.42  ? 90  SER B CB  1 
ATOM   2413 O OG  . SER B 2 90  ? 194.356 208.215 333.546 1.00 76.58  ? 90  SER B OG  1 
ATOM   2414 N N   . THR B 2 91  ? 191.257 205.814 332.807 1.00 51.82  ? 91  THR B N   1 
ATOM   2415 C CA  . THR B 2 91  ? 190.110 206.070 331.951 1.00 54.63  ? 91  THR B CA  1 
ATOM   2416 C C   . THR B 2 91  ? 189.005 206.702 332.780 1.00 59.34  ? 91  THR B C   1 
ATOM   2417 O O   . THR B 2 91  ? 188.788 206.323 333.934 1.00 59.16  ? 91  THR B O   1 
ATOM   2418 C CB  . THR B 2 91  ? 189.599 204.786 331.288 1.00 59.17  ? 91  THR B CB  1 
ATOM   2419 O OG1 . THR B 2 91  ? 190.630 204.226 330.466 1.00 63.94  ? 91  THR B OG1 1 
ATOM   2420 C CG2 . THR B 2 91  ? 188.373 205.075 330.433 1.00 56.44  ? 91  THR B CG2 1 
ATOM   2421 N N   . ILE B 2 92  ? 188.309 207.665 332.180 1.00 63.41  ? 92  ILE B N   1 
ATOM   2422 C CA  . ILE B 2 92  ? 187.205 208.371 332.814 1.00 55.58  ? 92  ILE B CA  1 
ATOM   2423 C C   . ILE B 2 92  ? 185.997 208.229 331.904 1.00 49.84  ? 92  ILE B C   1 
ATOM   2424 O O   . ILE B 2 92  ? 186.118 208.386 330.685 1.00 54.10  ? 92  ILE B O   1 
ATOM   2425 C CB  . ILE B 2 92  ? 187.522 209.863 333.048 1.00 51.04  ? 92  ILE B CB  1 
ATOM   2426 C CG1 . ILE B 2 92  ? 188.991 210.072 333.424 1.00 62.04  ? 92  ILE B CG1 1 
ATOM   2427 C CG2 . ILE B 2 92  ? 186.617 210.437 334.130 1.00 49.42  ? 92  ILE B CG2 1 
ATOM   2428 C CD1 . ILE B 2 92  ? 189.393 209.434 334.708 1.00 57.16  ? 92  ILE B CD1 1 
ATOM   2429 N N   . THR B 2 93  ? 184.843 207.917 332.491 1.00 60.78  ? 93  THR B N   1 
ATOM   2430 C CA  . THR B 2 93  ? 183.586 207.825 331.763 1.00 66.62  ? 93  THR B CA  1 
ATOM   2431 C C   . THR B 2 93  ? 182.538 208.675 332.463 1.00 67.59  ? 93  THR B C   1 
ATOM   2432 O O   . THR B 2 93  ? 182.567 208.843 333.684 1.00 72.62  ? 93  THR B O   1 
ATOM   2433 C CB  . THR B 2 93  ? 183.079 206.376 331.662 1.00 64.45  ? 93  THR B CB  1 
ATOM   2434 O OG1 . THR B 2 93  ? 182.945 205.817 332.974 1.00 65.29  ? 93  THR B OG1 1 
ATOM   2435 C CG2 . THR B 2 93  ? 184.033 205.523 330.843 1.00 61.82  ? 93  THR B CG2 1 
ATOM   2436 N N   . ALA B 2 94  ? 181.609 209.210 331.675 1.00 64.34  ? 94  ALA B N   1 
ATOM   2437 C CA  . ALA B 2 94  ? 180.507 210.001 332.217 1.00 62.75  ? 94  ALA B CA  1 
ATOM   2438 C C   . ALA B 2 94  ? 179.404 210.032 331.176 1.00 67.46  ? 94  ALA B C   1 
ATOM   2439 O O   . ALA B 2 94  ? 179.606 210.564 330.081 1.00 67.80  ? 94  ALA B O   1 
ATOM   2440 C CB  . ALA B 2 94  ? 180.966 211.413 332.571 1.00 63.91  ? 94  ALA B CB  1 
ATOM   2441 N N   . GLN B 2 95  ? 178.247 209.459 331.509 1.00 74.97  ? 95  GLN B N   1 
ATOM   2442 C CA  . GLN B 2 95  ? 177.155 209.351 330.552 1.00 74.45  ? 95  GLN B CA  1 
ATOM   2443 C C   . GLN B 2 95  ? 176.321 210.619 330.445 1.00 79.06  ? 95  GLN B C   1 
ATOM   2444 O O   . GLN B 2 95  ? 175.541 210.748 329.496 1.00 75.70  ? 95  GLN B O   1 
ATOM   2445 C CB  . GLN B 2 95  ? 176.246 208.179 330.929 1.00 71.27  ? 95  GLN B CB  1 
ATOM   2446 C CG  . GLN B 2 95  ? 176.957 206.844 330.973 1.00 74.51  ? 95  GLN B CG  1 
ATOM   2447 C CD  . GLN B 2 95  ? 176.005 205.694 331.209 1.00 77.15  ? 95  GLN B CD  1 
ATOM   2448 O OE1 . GLN B 2 95  ? 175.044 205.507 330.464 1.00 76.74  ? 95  GLN B OE1 1 
ATOM   2449 N NE2 . GLN B 2 95  ? 176.262 204.918 332.253 1.00 72.33  ? 95  GLN B NE2 1 
ATOM   2450 N N   . GLU B 2 96  ? 176.461 211.553 331.384 1.00 77.92  ? 96  GLU B N   1 
ATOM   2451 C CA  . GLU B 2 96  ? 175.666 212.778 331.399 1.00 78.26  ? 96  GLU B CA  1 
ATOM   2452 C C   . GLU B 2 96  ? 176.576 213.983 331.653 1.00 80.57  ? 96  GLU B C   1 
ATOM   2453 O O   . GLU B 2 96  ? 176.285 214.849 332.477 1.00 82.07  ? 96  GLU B O   1 
ATOM   2454 C CB  . GLU B 2 96  ? 174.554 212.695 332.440 1.00 73.23  ? 96  GLU B CB  1 
ATOM   2455 C CG  . GLU B 2 96  ? 173.354 213.562 332.121 1.00 71.50  ? 96  GLU B CG  1 
ATOM   2456 C CD  . GLU B 2 96  ? 172.295 213.498 333.197 1.00 78.41  ? 96  GLU B CD  1 
ATOM   2457 O OE1 . GLU B 2 96  ? 172.578 212.934 334.274 1.00 80.12  ? 96  GLU B OE1 1 
ATOM   2458 O OE2 . GLU B 2 96  ? 171.180 214.010 332.966 1.00 76.10  ? 96  GLU B OE2 1 
ATOM   2459 N N   . ALA B 2 97  ? 177.690 214.039 330.929 1.00 67.46  ? 97  ALA B N   1 
ATOM   2460 C CA  . ALA B 2 97  ? 178.610 215.167 330.987 1.00 63.56  ? 97  ALA B CA  1 
ATOM   2461 C C   . ALA B 2 97  ? 178.351 216.064 329.786 1.00 74.70  ? 97  ALA B C   1 
ATOM   2462 O O   . ALA B 2 97  ? 178.309 215.583 328.650 1.00 74.95  ? 97  ALA B O   1 
ATOM   2463 C CB  . ALA B 2 97  ? 180.066 214.694 330.991 1.00 63.04  ? 97  ALA B CB  1 
ATOM   2464 N N   . ALA B 2 98  ? 178.183 217.363 330.036 1.00 76.81  ? 98  ALA B N   1 
ATOM   2465 C CA  . ALA B 2 98  ? 177.717 218.296 329.008 1.00 71.78  ? 98  ALA B CA  1 
ATOM   2466 C C   . ALA B 2 98  ? 178.890 218.845 328.195 1.00 66.64  ? 98  ALA B C   1 
ATOM   2467 O O   . ALA B 2 98  ? 179.162 220.042 328.165 1.00 66.67  ? 98  ALA B O   1 
ATOM   2468 C CB  . ALA B 2 98  ? 176.913 219.423 329.647 1.00 64.28  ? 98  ALA B CB  1 
ATOM   2469 N N   . ASN B 2 99  ? 179.589 217.931 327.522 1.00 65.29  ? 99  ASN B N   1 
ATOM   2470 C CA  . ASN B 2 99  ? 180.683 218.307 326.635 1.00 66.92  ? 99  ASN B CA  1 
ATOM   2471 C C   . ASN B 2 99  ? 181.842 218.863 327.454 1.00 65.65  ? 99  ASN B C   1 
ATOM   2472 O O   . ASN B 2 99  ? 181.788 218.869 328.688 1.00 60.58  ? 99  ASN B O   1 
ATOM   2473 C CB  . ASN B 2 99  ? 180.212 219.322 325.586 1.00 65.38  ? 99  ASN B CB  1 
ATOM   2474 C CG  . ASN B 2 99  ? 180.480 218.860 324.166 1.00 65.62  ? 99  ASN B CG  1 
ATOM   2475 O OD1 . ASN B 2 99  ? 181.479 218.195 323.897 1.00 68.40  ? 99  ASN B OD1 1 
ATOM   2476 N ND2 . ASN B 2 99  ? 179.586 219.214 323.248 1.00 62.66  ? 99  ASN B ND2 1 
ATOM   2477 N N   . SER B 2 100 ? 182.889 219.340 326.784 1.00 58.58  ? 100 SER B N   1 
ATOM   2478 C CA  . SER B 2 100 ? 184.097 219.809 327.450 1.00 53.22  ? 100 SER B CA  1 
ATOM   2479 C C   . SER B 2 100 ? 184.411 221.231 327.012 1.00 55.71  ? 100 SER B C   1 
ATOM   2480 O O   . SER B 2 100 ? 183.956 221.695 325.965 1.00 59.84  ? 100 SER B O   1 
ATOM   2481 C CB  . SER B 2 100 ? 185.298 218.909 327.141 1.00 57.40  ? 100 SER B CB  1 
ATOM   2482 O OG  . SER B 2 100 ? 185.730 219.076 325.802 1.00 59.28  ? 100 SER B OG  1 
ATOM   2483 N N   . VAL B 2 101 ? 185.200 221.921 327.833 1.00 45.39  ? 101 VAL B N   1 
ATOM   2484 C CA  . VAL B 2 101 ? 185.678 223.268 327.538 1.00 43.26  ? 101 VAL B CA  1 
ATOM   2485 C C   . VAL B 2 101 ? 187.184 223.195 327.335 1.00 51.60  ? 101 VAL B C   1 
ATOM   2486 O O   . VAL B 2 101 ? 187.928 222.870 328.268 1.00 61.19  ? 101 VAL B O   1 
ATOM   2487 C CB  . VAL B 2 101 ? 185.326 224.256 328.660 1.00 39.08  ? 101 VAL B CB  1 
ATOM   2488 C CG1 . VAL B 2 101 ? 186.138 225.538 328.517 1.00 50.84  ? 101 VAL B CG1 1 
ATOM   2489 C CG2 . VAL B 2 101 ? 183.847 224.567 328.653 1.00 47.48  ? 101 VAL B CG2 1 
ATOM   2490 N N   . VAL B 2 102 ? 187.635 223.492 326.119 1.00 40.39  ? 102 VAL B N   1 
ATOM   2491 C CA  . VAL B 2 102 ? 189.061 223.661 325.847 1.00 39.29  ? 102 VAL B CA  1 
ATOM   2492 C C   . VAL B 2 102 ? 189.360 225.121 326.169 1.00 39.90  ? 102 VAL B C   1 
ATOM   2493 O O   . VAL B 2 102 ? 189.208 226.013 325.334 1.00 52.00  ? 102 VAL B O   1 
ATOM   2494 C CB  . VAL B 2 102 ? 189.422 223.291 324.415 1.00 42.22  ? 102 VAL B CB  1 
ATOM   2495 C CG1 . VAL B 2 102 ? 190.933 223.283 324.237 1.00 46.98  ? 102 VAL B CG1 1 
ATOM   2496 C CG2 . VAL B 2 102 ? 188.836 221.937 324.072 1.00 39.89  ? 102 VAL B CG2 1 
ATOM   2497 N N   . ALA B 2 103 ? 189.774 225.365 327.409 1.00 28.54  ? 103 ALA B N   1 
ATOM   2498 C CA  . ALA B 2 103 ? 189.979 226.724 327.883 1.00 42.63  ? 103 ALA B CA  1 
ATOM   2499 C C   . ALA B 2 103 ? 190.803 227.521 326.883 1.00 46.76  ? 103 ALA B C   1 
ATOM   2500 O O   . ALA B 2 103 ? 191.919 227.135 326.527 1.00 46.66  ? 103 ALA B O   1 
ATOM   2501 C CB  . ALA B 2 103 ? 190.667 226.694 329.247 1.00 42.64  ? 103 ALA B CB  1 
ATOM   2502 N N   . TYR B 2 104 ? 190.238 228.636 326.429 1.00 32.63  ? 104 TYR B N   1 
ATOM   2503 C CA  . TYR B 2 104 ? 190.868 229.526 325.459 1.00 31.45  ? 104 TYR B CA  1 
ATOM   2504 C C   . TYR B 2 104 ? 191.099 228.848 324.115 1.00 40.52  ? 104 TYR B C   1 
ATOM   2505 O O   . TYR B 2 104 ? 191.872 229.346 323.293 1.00 43.79  ? 104 TYR B O   1 
ATOM   2506 C CB  . TYR B 2 104 ? 192.184 230.083 326.007 1.00 36.32  ? 104 TYR B CB  1 
ATOM   2507 C CG  . TYR B 2 104 ? 192.008 230.885 327.270 1.00 32.87  ? 104 TYR B CG  1 
ATOM   2508 C CD1 . TYR B 2 104 ? 191.098 231.926 327.331 1.00 36.61  ? 104 TYR B CD1 1 
ATOM   2509 C CD2 . TYR B 2 104 ? 192.741 230.593 328.408 1.00 32.21  ? 104 TYR B CD2 1 
ATOM   2510 C CE1 . TYR B 2 104 ? 190.928 232.659 328.480 1.00 37.72  ? 104 TYR B CE1 1 
ATOM   2511 C CE2 . TYR B 2 104 ? 192.578 231.321 329.564 1.00 29.09  ? 104 TYR B CE2 1 
ATOM   2512 C CZ  . TYR B 2 104 ? 191.671 232.352 329.595 1.00 36.01  ? 104 TYR B CZ  1 
ATOM   2513 O OH  . TYR B 2 104 ? 191.501 233.084 330.745 1.00 41.58  ? 104 TYR B OH  1 
ATOM   2514 N N   . GLY B 2 105 ? 190.442 227.719 323.873 1.00 45.05  ? 105 GLY B N   1 
ATOM   2515 C CA  . GLY B 2 105 ? 190.548 227.051 322.584 1.00 43.65  ? 105 GLY B CA  1 
ATOM   2516 C C   . GLY B 2 105 ? 191.963 226.680 322.202 1.00 48.41  ? 105 GLY B C   1 
ATOM   2517 O O   . GLY B 2 105 ? 192.344 226.812 321.032 1.00 50.85  ? 105 GLY B O   1 
ATOM   2518 N N   . ARG B 2 106 ? 192.754 226.214 323.165 1.00 50.35  ? 106 ARG B N   1 
ATOM   2519 C CA  . ARG B 2 106 ? 194.138 225.816 322.929 1.00 45.71  ? 106 ARG B CA  1 
ATOM   2520 C C   . ARG B 2 106 ? 194.387 224.492 323.634 1.00 51.00  ? 106 ARG B C   1 
ATOM   2521 O O   . ARG B 2 106 ? 194.343 224.424 324.866 1.00 51.20  ? 106 ARG B O   1 
ATOM   2522 C CB  . ARG B 2 106 ? 195.111 226.885 323.425 1.00 42.42  ? 106 ARG B CB  1 
ATOM   2523 C CG  . ARG B 2 106 ? 195.163 228.133 322.563 1.00 44.38  ? 106 ARG B CG  1 
ATOM   2524 C CD  . ARG B 2 106 ? 195.761 227.850 321.198 1.00 48.52  ? 106 ARG B CD  1 
ATOM   2525 N NE  . ARG B 2 106 ? 197.065 227.208 321.297 1.00 52.87  ? 106 ARG B NE  1 
ATOM   2526 C CZ  . ARG B 2 106 ? 198.202 227.850 321.531 1.00 55.64  ? 106 ARG B CZ  1 
ATOM   2527 N NH1 . ARG B 2 106 ? 198.233 229.161 321.704 1.00 52.35  ? 106 ARG B NH1 1 
ATOM   2528 N NH2 . ARG B 2 106 ? 199.335 227.158 321.595 1.00 52.72  ? 106 ARG B NH2 1 
ATOM   2529 N N   . TRP B 2 107 ? 194.645 223.449 322.861 1.00 50.29  ? 107 TRP B N   1 
ATOM   2530 C CA  . TRP B 2 107 ? 194.974 222.164 323.457 1.00 46.28  ? 107 TRP B CA  1 
ATOM   2531 C C   . TRP B 2 107 ? 196.406 222.192 323.990 1.00 53.18  ? 107 TRP B C   1 
ATOM   2532 O O   . TRP B 2 107 ? 197.282 222.804 323.374 1.00 61.84  ? 107 TRP B O   1 
ATOM   2533 C CB  . TRP B 2 107 ? 194.824 221.046 322.430 1.00 46.27  ? 107 TRP B CB  1 
ATOM   2534 C CG  . TRP B 2 107 ? 194.422 219.741 323.028 1.00 53.07  ? 107 TRP B CG  1 
ATOM   2535 C CD1 . TRP B 2 107 ? 195.242 218.711 323.379 1.00 55.06  ? 107 TRP B CD1 1 
ATOM   2536 C CD2 . TRP B 2 107 ? 193.093 219.323 323.349 1.00 52.19  ? 107 TRP B CD2 1 
ATOM   2537 N NE1 . TRP B 2 107 ? 194.506 217.676 323.898 1.00 49.24  ? 107 TRP B NE1 1 
ATOM   2538 C CE2 . TRP B 2 107 ? 193.182 218.028 323.891 1.00 51.27  ? 107 TRP B CE2 1 
ATOM   2539 C CE3 . TRP B 2 107 ? 191.835 219.919 323.230 1.00 48.40  ? 107 TRP B CE3 1 
ATOM   2540 C CZ2 . TRP B 2 107 ? 192.063 217.319 324.313 1.00 52.39  ? 107 TRP B CZ2 1 
ATOM   2541 C CZ3 . TRP B 2 107 ? 190.727 219.214 323.648 1.00 51.49  ? 107 TRP B CZ3 1 
ATOM   2542 C CH2 . TRP B 2 107 ? 190.846 217.928 324.184 1.00 55.28  ? 107 TRP B CH2 1 
ATOM   2543 N N   . PRO B 2 108 ? 196.678 221.549 325.127 1.00 50.55  ? 108 PRO B N   1 
ATOM   2544 C CA  . PRO B 2 108 ? 198.054 221.530 325.635 1.00 50.04  ? 108 PRO B CA  1 
ATOM   2545 C C   . PRO B 2 108 ? 199.009 220.941 324.609 1.00 49.66  ? 108 PRO B C   1 
ATOM   2546 O O   . PRO B 2 108 ? 198.692 219.965 323.928 1.00 49.59  ? 108 PRO B O   1 
ATOM   2547 C CB  . PRO B 2 108 ? 197.957 220.654 326.888 1.00 48.06  ? 108 PRO B CB  1 
ATOM   2548 C CG  . PRO B 2 108 ? 196.548 220.766 327.318 1.00 45.57  ? 108 PRO B CG  1 
ATOM   2549 C CD  . PRO B 2 108 ? 195.743 220.904 326.064 1.00 48.29  ? 108 PRO B CD  1 
ATOM   2550 N N   . GLU B 2 109 ? 200.189 221.548 324.502 1.00 58.60  ? 109 GLU B N   1 
ATOM   2551 C CA  . GLU B 2 109 ? 201.191 221.123 323.537 1.00 61.75  ? 109 GLU B CA  1 
ATOM   2552 C C   . GLU B 2 109 ? 202.561 221.117 324.194 1.00 64.98  ? 109 GLU B C   1 
ATOM   2553 O O   . GLU B 2 109 ? 202.833 221.900 325.108 1.00 70.23  ? 109 GLU B O   1 
ATOM   2554 C CB  . GLU B 2 109 ? 201.215 222.039 322.306 1.00 60.94  ? 109 GLU B CB  1 
ATOM   2555 C CG  . GLU B 2 109 ? 201.699 223.454 322.591 1.00 65.75  ? 109 GLU B CG  1 
ATOM   2556 C CD  . GLU B 2 109 ? 201.711 224.328 321.352 1.00 73.03  ? 109 GLU B CD  1 
ATOM   2557 O OE1 . GLU B 2 109 ? 201.228 223.870 320.295 1.00 74.09  ? 109 GLU B OE1 1 
ATOM   2558 O OE2 . GLU B 2 109 ? 202.206 225.472 321.435 1.00 65.87  ? 109 GLU B OE2 1 
ATOM   2559 N N   . TYR B 2 110 ? 203.424 220.224 323.717 1.00 58.20  ? 110 TYR B N   1 
ATOM   2560 C CA  . TYR B 2 110 ? 204.808 220.219 324.164 1.00 56.88  ? 110 TYR B CA  1 
ATOM   2561 C C   . TYR B 2 110 ? 205.506 221.497 323.718 1.00 62.03  ? 110 TYR B C   1 
ATOM   2562 O O   . TYR B 2 110 ? 205.152 222.104 322.704 1.00 64.64  ? 110 TYR B O   1 
ATOM   2563 C CB  . TYR B 2 110 ? 205.548 219.003 323.608 1.00 63.95  ? 110 TYR B CB  1 
ATOM   2564 C CG  . TYR B 2 110 ? 205.309 217.726 324.376 1.00 62.59  ? 110 TYR B CG  1 
ATOM   2565 C CD1 . TYR B 2 110 ? 206.007 217.457 325.543 1.00 63.52  ? 110 TYR B CD1 1 
ATOM   2566 C CD2 . TYR B 2 110 ? 204.396 216.784 323.929 1.00 58.95  ? 110 TYR B CD2 1 
ATOM   2567 C CE1 . TYR B 2 110 ? 205.797 216.293 326.247 1.00 63.31  ? 110 TYR B CE1 1 
ATOM   2568 C CE2 . TYR B 2 110 ? 204.180 215.616 324.626 1.00 58.98  ? 110 TYR B CE2 1 
ATOM   2569 C CZ  . TYR B 2 110 ? 204.883 215.375 325.785 1.00 65.91  ? 110 TYR B CZ  1 
ATOM   2570 O OH  . TYR B 2 110 ? 204.672 214.212 326.487 1.00 73.37  ? 110 TYR B OH  1 
ATOM   2571 N N   . LEU B 2 111 ? 206.506 221.909 324.492 1.00 57.48  ? 111 LEU B N   1 
ATOM   2572 C CA  . LEU B 2 111 ? 207.250 223.115 324.160 1.00 58.08  ? 111 LEU B CA  1 
ATOM   2573 C C   . LEU B 2 111 ? 207.875 222.982 322.779 1.00 61.30  ? 111 LEU B C   1 
ATOM   2574 O O   . LEU B 2 111 ? 208.507 221.971 322.463 1.00 63.02  ? 111 LEU B O   1 
ATOM   2575 C CB  . LEU B 2 111 ? 208.330 223.372 325.211 1.00 57.39  ? 111 LEU B CB  1 
ATOM   2576 C CG  . LEU B 2 111 ? 209.144 224.659 325.062 1.00 61.59  ? 111 LEU B CG  1 
ATOM   2577 C CD1 . LEU B 2 111 ? 208.267 225.890 325.192 1.00 56.63  ? 111 LEU B CD1 1 
ATOM   2578 C CD2 . LEU B 2 111 ? 210.256 224.695 326.091 1.00 66.79  ? 111 LEU B CD2 1 
ATOM   2579 N N   . ARG B 2 112 ? 207.692 224.008 321.955 1.00 70.05  ? 112 ARG B N   1 
ATOM   2580 C CA  . ARG B 2 112 ? 208.250 224.046 320.612 1.00 71.17  ? 112 ARG B CA  1 
ATOM   2581 C C   . ARG B 2 112 ? 209.558 224.824 320.628 1.00 77.36  ? 112 ARG B C   1 
ATOM   2582 O O   . ARG B 2 112 ? 209.649 225.892 321.238 1.00 82.20  ? 112 ARG B O   1 
ATOM   2583 C CB  . ARG B 2 112 ? 207.268 224.683 319.629 1.00 74.28  ? 112 ARG B CB  1 
ATOM   2584 C CG  . ARG B 2 112 ? 206.024 223.845 319.378 1.00 74.86  ? 112 ARG B CG  1 
ATOM   2585 C CD  . ARG B 2 112 ? 205.101 224.489 318.356 1.00 75.19  ? 112 ARG B CD  1 
ATOM   2586 N NE  . ARG B 2 112 ? 204.475 225.706 318.860 1.00 75.05  ? 112 ARG B NE  1 
ATOM   2587 C CZ  . ARG B 2 112 ? 204.978 226.926 318.726 1.00 77.14  ? 112 ARG B CZ  1 
ATOM   2588 N NH1 . ARG B 2 112 ? 206.131 227.139 318.114 1.00 79.73  ? 112 ARG B NH1 1 
ATOM   2589 N NH2 . ARG B 2 112 ? 204.306 227.961 319.221 1.00 75.96  ? 112 ARG B NH2 1 
ATOM   2590 N N   . ASP B 2 113 ? 210.569 224.281 319.947 1.00 79.02  ? 113 ASP B N   1 
ATOM   2591 C CA  . ASP B 2 113 ? 211.901 224.871 320.009 1.00 77.11  ? 113 ASP B CA  1 
ATOM   2592 C C   . ASP B 2 113 ? 211.901 226.320 319.540 1.00 80.22  ? 113 ASP B C   1 
ATOM   2593 O O   . ASP B 2 113 ? 212.770 227.101 319.946 1.00 79.83  ? 113 ASP B O   1 
ATOM   2594 C CB  . ASP B 2 113 ? 212.876 224.042 319.175 1.00 80.20  ? 113 ASP B CB  1 
ATOM   2595 C CG  . ASP B 2 113 ? 213.049 222.635 319.713 1.00 84.74  ? 113 ASP B CG  1 
ATOM   2596 O OD1 . ASP B 2 113 ? 212.905 222.445 320.939 1.00 83.43  ? 113 ASP B OD1 1 
ATOM   2597 O OD2 . ASP B 2 113 ? 213.327 221.718 318.913 1.00 85.70  ? 113 ASP B OD2 1 
ATOM   2598 N N   . SER B 2 114 ? 210.941 226.702 318.696 1.00 85.00  ? 114 SER B N   1 
ATOM   2599 C CA  . SER B 2 114 ? 210.877 228.081 318.228 1.00 84.22  ? 114 SER B CA  1 
ATOM   2600 C C   . SER B 2 114 ? 210.703 229.070 319.372 1.00 84.65  ? 114 SER B C   1 
ATOM   2601 O O   . SER B 2 114 ? 211.044 230.247 319.215 1.00 85.84  ? 114 SER B O   1 
ATOM   2602 C CB  . SER B 2 114 ? 209.734 228.244 317.225 1.00 80.18  ? 114 SER B CB  1 
ATOM   2603 O OG  . SER B 2 114 ? 208.477 228.059 317.850 1.00 78.61  ? 114 SER B OG  1 
ATOM   2604 N N   . GLU B 2 115 ? 210.178 228.626 320.512 1.00 77.37  ? 115 GLU B N   1 
ATOM   2605 C CA  . GLU B 2 115 ? 209.963 229.471 321.683 1.00 74.83  ? 115 GLU B CA  1 
ATOM   2606 C C   . GLU B 2 115 ? 210.510 228.791 322.931 1.00 75.66  ? 115 GLU B C   1 
ATOM   2607 O O   . GLU B 2 115 ? 209.860 228.729 323.976 1.00 76.63  ? 115 GLU B O   1 
ATOM   2608 C CB  . GLU B 2 115 ? 208.483 229.795 321.852 1.00 74.93  ? 115 GLU B CB  1 
ATOM   2609 C CG  . GLU B 2 115 ? 207.594 228.575 322.022 1.00 75.59  ? 115 GLU B CG  1 
ATOM   2610 C CD  . GLU B 2 115 ? 206.148 228.946 322.273 1.00 79.93  ? 115 GLU B CD  1 
ATOM   2611 O OE1 . GLU B 2 115 ? 205.747 230.062 321.882 1.00 78.55  ? 115 GLU B OE1 1 
ATOM   2612 O OE2 . GLU B 2 115 ? 205.415 228.126 322.866 1.00 78.87  ? 115 GLU B OE2 1 
ATOM   2613 N N   . ALA B 2 116 ? 211.733 228.274 322.833 1.00 72.86  ? 116 ALA B N   1 
ATOM   2614 C CA  . ALA B 2 116 ? 212.359 227.490 323.893 1.00 70.03  ? 116 ALA B CA  1 
ATOM   2615 C C   . ALA B 2 116 ? 213.465 228.312 324.540 1.00 73.39  ? 116 ALA B C   1 
ATOM   2616 O O   . ALA B 2 116 ? 214.458 228.647 323.887 1.00 74.43  ? 116 ALA B O   1 
ATOM   2617 C CB  . ALA B 2 116 ? 212.911 226.184 323.332 1.00 70.17  ? 116 ALA B CB  1 
ATOM   2618 N N   . ASN B 2 117 ? 213.292 228.633 325.821 1.00 77.96  ? 117 ASN B N   1 
ATOM   2619 C CA  . ASN B 2 117 ? 214.269 229.429 326.552 1.00 75.47  ? 117 ASN B CA  1 
ATOM   2620 C C   . ASN B 2 117 ? 215.441 228.578 327.043 1.00 74.94  ? 117 ASN B C   1 
ATOM   2621 O O   . ASN B 2 117 ? 216.596 228.893 326.726 1.00 70.81  ? 117 ASN B O   1 
ATOM   2622 C CB  . ASN B 2 117 ? 213.587 230.150 327.717 1.00 67.75  ? 117 ASN B CB  1 
ATOM   2623 C CG  . ASN B 2 117 ? 214.571 230.846 328.628 1.00 75.51  ? 117 ASN B CG  1 
ATOM   2624 O OD1 . ASN B 2 117 ? 215.671 231.206 328.213 1.00 77.50  ? 117 ASN B OD1 1 
ATOM   2625 N ND2 . ASN B 2 117 ? 214.180 231.039 329.881 1.00 78.40  ? 117 ASN B ND2 1 
ATOM   2626 N N   . PRO B 2 118 ? 215.210 227.507 327.802 1.00 67.58  ? 118 PRO B N   1 
ATOM   2627 C CA  . PRO B 2 118 ? 216.331 226.701 328.294 1.00 66.87  ? 118 PRO B CA  1 
ATOM   2628 C C   . PRO B 2 118 ? 216.860 225.749 327.231 1.00 68.75  ? 118 PRO B C   1 
ATOM   2629 O O   . PRO B 2 118 ? 216.225 225.493 326.207 1.00 73.12  ? 118 PRO B O   1 
ATOM   2630 C CB  . PRO B 2 118 ? 215.718 225.931 329.465 1.00 64.47  ? 118 PRO B CB  1 
ATOM   2631 C CG  . PRO B 2 118 ? 214.313 225.746 329.061 1.00 69.10  ? 118 PRO B CG  1 
ATOM   2632 C CD  . PRO B 2 118 ? 213.922 226.986 328.295 1.00 65.61  ? 118 PRO B CD  1 
ATOM   2633 N N   . VAL B 2 119 ? 218.049 225.213 327.505 1.00 68.90  ? 119 VAL B N   1 
ATOM   2634 C CA  . VAL B 2 119 ? 218.762 224.376 326.544 1.00 70.45  ? 119 VAL B CA  1 
ATOM   2635 C C   . VAL B 2 119 ? 218.705 222.911 326.957 1.00 76.22  ? 119 VAL B C   1 
ATOM   2636 O O   . VAL B 2 119 ? 218.769 222.014 326.108 1.00 76.34  ? 119 VAL B O   1 
ATOM   2637 C CB  . VAL B 2 119 ? 220.223 224.837 326.401 1.00 67.74  ? 119 VAL B CB  1 
ATOM   2638 C CG1 . VAL B 2 119 ? 220.288 226.335 326.163 1.00 68.70  ? 119 VAL B CG1 1 
ATOM   2639 C CG2 . VAL B 2 119 ? 221.024 224.451 327.633 1.00 69.74  ? 119 VAL B CG2 1 
ATOM   2640 N N   . ASP B 2 120 ? 218.585 222.656 328.257 1.00 81.38  ? 120 ASP B N   1 
ATOM   2641 C CA  . ASP B 2 120 ? 218.699 221.295 328.766 1.00 75.00  ? 120 ASP B CA  1 
ATOM   2642 C C   . ASP B 2 120 ? 217.640 220.389 328.154 1.00 73.48  ? 120 ASP B C   1 
ATOM   2643 O O   . ASP B 2 120 ? 216.499 220.799 327.928 1.00 76.15  ? 120 ASP B O   1 
ATOM   2644 C CB  . ASP B 2 120 ? 218.571 221.294 330.288 1.00 71.55  ? 120 ASP B CB  1 
ATOM   2645 C CG  . ASP B 2 120 ? 219.662 222.095 330.958 1.00 76.20  ? 120 ASP B CG  1 
ATOM   2646 O OD1 . ASP B 2 120 ? 219.845 223.270 330.583 1.00 78.58  ? 120 ASP B OD1 1 
ATOM   2647 O OD2 . ASP B 2 120 ? 220.337 221.551 331.856 1.00 78.66  ? 120 ASP B OD2 1 
ATOM   2648 N N   . GLN B 2 121 ? 218.028 219.146 327.891 1.00 63.64  ? 121 GLN B N   1 
ATOM   2649 C CA  . GLN B 2 121 ? 217.099 218.187 327.315 1.00 68.21  ? 121 GLN B CA  1 
ATOM   2650 C C   . GLN B 2 121 ? 215.923 217.985 328.266 1.00 74.40  ? 121 GLN B C   1 
ATOM   2651 O O   . GLN B 2 121 ? 216.135 217.716 329.457 1.00 75.89  ? 121 GLN B O   1 
ATOM   2652 C CB  . GLN B 2 121 ? 217.799 216.856 327.052 1.00 68.16  ? 121 GLN B CB  1 
ATOM   2653 C CG  . GLN B 2 121 ? 216.967 215.867 326.253 1.00 65.83  ? 121 GLN B CG  1 
ATOM   2654 C CD  . GLN B 2 121 ? 216.799 216.289 324.809 1.00 68.07  ? 121 GLN B CD  1 
ATOM   2655 O OE1 . GLN B 2 121 ? 217.661 216.957 324.243 1.00 76.16  ? 121 GLN B OE1 1 
ATOM   2656 N NE2 . GLN B 2 121 ? 215.683 215.903 324.204 1.00 67.50  ? 121 GLN B NE2 1 
ATOM   2657 N N   . PRO B 2 122 ? 214.683 218.099 327.794 1.00 65.18  ? 122 PRO B N   1 
ATOM   2658 C CA  . PRO B 2 122 ? 213.539 218.000 328.702 1.00 57.23  ? 122 PRO B CA  1 
ATOM   2659 C C   . PRO B 2 122 ? 213.149 216.558 328.971 1.00 65.41  ? 122 PRO B C   1 
ATOM   2660 O O   . PRO B 2 122 ? 213.160 215.710 328.076 1.00 67.62  ? 122 PRO B O   1 
ATOM   2661 C CB  . PRO B 2 122 ? 212.433 218.737 327.942 1.00 55.14  ? 122 PRO B CB  1 
ATOM   2662 C CG  . PRO B 2 122 ? 212.748 218.465 326.519 1.00 62.05  ? 122 PRO B CG  1 
ATOM   2663 C CD  . PRO B 2 122 ? 214.254 218.378 326.415 1.00 66.24  ? 122 PRO B CD  1 
ATOM   2664 N N   . THR B 2 123 ? 212.792 216.289 330.222 1.00 62.26  ? 123 THR B N   1 
ATOM   2665 C CA  . THR B 2 123 ? 212.306 214.980 330.638 1.00 62.49  ? 123 THR B CA  1 
ATOM   2666 C C   . THR B 2 123 ? 210.783 215.013 330.622 1.00 59.91  ? 123 THR B C   1 
ATOM   2667 O O   . THR B 2 123 ? 210.163 215.690 331.447 1.00 68.90  ? 123 THR B O   1 
ATOM   2668 C CB  . THR B 2 123 ? 212.823 214.617 332.026 1.00 66.00  ? 123 THR B CB  1 
ATOM   2669 O OG1 . THR B 2 123 ? 214.229 214.878 332.099 1.00 70.23  ? 123 THR B OG1 1 
ATOM   2670 C CG2 . THR B 2 123 ? 212.566 213.147 332.318 1.00 61.56  ? 123 THR B CG2 1 
ATOM   2671 N N   . GLU B 2 124 ? 210.182 214.281 329.686 1.00 63.32  ? 124 GLU B N   1 
ATOM   2672 C CA  . GLU B 2 124 ? 208.733 214.172 329.624 1.00 65.59  ? 124 GLU B CA  1 
ATOM   2673 C C   . GLU B 2 124 ? 208.318 212.827 330.199 1.00 71.95  ? 124 GLU B C   1 
ATOM   2674 O O   . GLU B 2 124 ? 208.566 211.792 329.562 1.00 71.29  ? 124 GLU B O   1 
ATOM   2675 C CB  . GLU B 2 124 ? 208.229 214.318 328.188 1.00 65.61  ? 124 GLU B CB  1 
ATOM   2676 C CG  . GLU B 2 124 ? 209.032 213.564 327.142 1.00 73.01  ? 124 GLU B CG  1 
ATOM   2677 C CD  . GLU B 2 124 ? 210.241 214.341 326.665 1.00 74.74  ? 124 GLU B CD  1 
ATOM   2678 O OE1 . GLU B 2 124 ? 210.564 215.372 327.290 1.00 76.59  ? 124 GLU B OE1 1 
ATOM   2679 O OE2 . GLU B 2 124 ? 210.865 213.925 325.667 1.00 72.96  ? 124 GLU B OE2 1 
ATOM   2680 N N   . PRO B 2 125 ? 207.701 212.778 331.381 1.00 65.65  ? 125 PRO B N   1 
ATOM   2681 C CA  . PRO B 2 125 ? 207.288 211.475 331.925 1.00 63.29  ? 125 PRO B CA  1 
ATOM   2682 C C   . PRO B 2 125 ? 206.336 210.722 331.018 1.00 63.23  ? 125 PRO B C   1 
ATOM   2683 O O   . PRO B 2 125 ? 206.377 209.486 330.980 1.00 60.03  ? 125 PRO B O   1 
ATOM   2684 C CB  . PRO B 2 125 ? 206.621 211.845 333.256 1.00 59.10  ? 125 PRO B CB  1 
ATOM   2685 C CG  . PRO B 2 125 ? 207.163 213.180 333.607 1.00 59.57  ? 125 PRO B CG  1 
ATOM   2686 C CD  . PRO B 2 125 ? 207.411 213.881 332.313 1.00 63.17  ? 125 PRO B CD  1 
ATOM   2687 N N   . GLU B 2 126 ? 205.475 211.429 330.287 1.00 67.35  ? 126 GLU B N   1 
ATOM   2688 C CA  . GLU B 2 126 ? 204.485 210.821 329.397 1.00 65.29  ? 126 GLU B CA  1 
ATOM   2689 C C   . GLU B 2 126 ? 203.526 210.010 330.259 1.00 66.79  ? 126 GLU B C   1 
ATOM   2690 O O   . GLU B 2 126 ? 202.820 210.607 331.090 1.00 70.97  ? 126 GLU B O   1 
ATOM   2691 C CB  . GLU B 2 126 ? 205.210 210.044 328.297 1.00 68.93  ? 126 GLU B CB  1 
ATOM   2692 C CG  . GLU B 2 126 ? 206.029 210.922 327.371 1.00 74.94  ? 126 GLU B CG  1 
ATOM   2693 C CD  . GLU B 2 126 ? 206.796 210.122 326.338 1.00 80.76  ? 126 GLU B CD  1 
ATOM   2694 O OE1 . GLU B 2 126 ? 206.907 208.888 326.502 1.00 81.64  ? 126 GLU B OE1 1 
ATOM   2695 O OE2 . GLU B 2 126 ? 207.288 210.727 325.363 1.00 74.30  ? 126 GLU B OE2 1 
ATOM   2696 N N   . VAL B 2 127 ? 203.465 208.687 330.119 1.00 56.50  ? 127 VAL B N   1 
ATOM   2697 C CA  . VAL B 2 127 ? 202.398 207.917 330.748 1.00 56.38  ? 127 VAL B CA  1 
ATOM   2698 C C   . VAL B 2 127 ? 202.503 207.975 332.268 1.00 58.20  ? 127 VAL B C   1 
ATOM   2699 O O   . VAL B 2 127 ? 201.488 207.983 332.972 1.00 56.72  ? 127 VAL B O   1 
ATOM   2700 C CB  . VAL B 2 127 ? 202.430 206.468 330.233 1.00 61.29  ? 127 VAL B CB  1 
ATOM   2701 C CG1 . VAL B 2 127 ? 201.235 205.698 330.745 1.00 58.84  ? 127 VAL B CG1 1 
ATOM   2702 C CG2 . VAL B 2 127 ? 202.476 206.458 328.712 1.00 61.74  ? 127 VAL B CG2 1 
ATOM   2703 N N   . ALA B 2 128 ? 203.726 208.005 332.800 1.00 55.99  ? 128 ALA B N   1 
ATOM   2704 C CA  . ALA B 2 128 ? 203.902 207.897 334.244 1.00 55.37  ? 128 ALA B CA  1 
ATOM   2705 C C   . ALA B 2 128 ? 203.377 209.109 335.001 1.00 52.26  ? 128 ALA B C   1 
ATOM   2706 O O   . ALA B 2 128 ? 203.144 209.008 336.210 1.00 40.92  ? 128 ALA B O   1 
ATOM   2707 C CB  . ALA B 2 128 ? 205.376 207.688 334.582 1.00 57.86  ? 128 ALA B CB  1 
ATOM   2708 N N   . ALA B 2 129 ? 203.191 210.247 334.333 1.00 57.15  ? 129 ALA B N   1 
ATOM   2709 C CA  . ALA B 2 129 ? 202.720 211.455 334.993 1.00 58.16  ? 129 ALA B CA  1 
ATOM   2710 C C   . ALA B 2 129 ? 201.464 212.044 334.380 1.00 45.25  ? 129 ALA B C   1 
ATOM   2711 O O   . ALA B 2 129 ? 200.782 212.822 335.055 1.00 47.64  ? 129 ALA B O   1 
ATOM   2712 C CB  . ALA B 2 129 ? 203.812 212.536 334.987 1.00 58.10  ? 129 ALA B CB  1 
ATOM   2713 N N   . CYS B 2 130 ? 201.135 211.704 333.138 1.00 47.40  ? 130 CYS B N   1 
ATOM   2714 C CA  . CYS B 2 130 ? 199.927 212.214 332.494 1.00 52.73  ? 130 CYS B CA  1 
ATOM   2715 C C   . CYS B 2 130 ? 198.749 211.276 332.757 1.00 57.31  ? 130 CYS B C   1 
ATOM   2716 O O   . CYS B 2 130 ? 198.110 210.751 331.848 1.00 58.58  ? 130 CYS B O   1 
ATOM   2717 C CB  . CYS B 2 130 ? 200.166 212.399 331.001 1.00 56.40  ? 130 CYS B CB  1 
ATOM   2718 S SG  . CYS B 2 130 ? 201.541 213.500 330.608 1.00 61.04  ? 130 CYS B SG  1 
ATOM   2719 N N   . ARG B 2 131 ? 198.470 211.076 334.040 1.00 50.82  ? 131 ARG B N   1 
ATOM   2720 C CA  . ARG B 2 131 ? 197.391 210.216 334.496 1.00 44.47  ? 131 ARG B CA  1 
ATOM   2721 C C   . ARG B 2 131 ? 196.356 211.035 335.248 1.00 45.42  ? 131 ARG B C   1 
ATOM   2722 O O   . ARG B 2 131 ? 196.600 212.173 335.648 1.00 58.73  ? 131 ARG B O   1 
ATOM   2723 C CB  . ARG B 2 131 ? 197.910 209.110 335.414 1.00 47.45  ? 131 ARG B CB  1 
ATOM   2724 C CG  . ARG B 2 131 ? 198.937 208.195 334.801 1.00 57.49  ? 131 ARG B CG  1 
ATOM   2725 C CD  . ARG B 2 131 ? 199.427 207.202 335.834 1.00 59.69  ? 131 ARG B CD  1 
ATOM   2726 N NE  . ARG B 2 131 ? 198.318 206.559 336.531 1.00 61.67  ? 131 ARG B NE  1 
ATOM   2727 C CZ  . ARG B 2 131 ? 197.794 206.989 337.672 1.00 57.15  ? 131 ARG B CZ  1 
ATOM   2728 N NH1 . ARG B 2 131 ? 198.263 208.058 338.292 1.00 52.34  ? 131 ARG B NH1 1 
ATOM   2729 N NH2 . ARG B 2 131 ? 196.766 206.333 338.200 1.00 55.63  ? 131 ARG B NH2 1 
ATOM   2730 N N   . PHE B 2 132 ? 195.198 210.422 335.470 1.00 39.86  ? 132 PHE B N   1 
ATOM   2731 C CA  . PHE B 2 132 ? 194.108 211.050 336.208 1.00 39.91  ? 132 PHE B CA  1 
ATOM   2732 C C   . PHE B 2 132 ? 194.250 210.717 337.688 1.00 38.97  ? 132 PHE B C   1 
ATOM   2733 O O   . PHE B 2 132 ? 194.044 209.570 338.095 1.00 49.88  ? 132 PHE B O   1 
ATOM   2734 C CB  . PHE B 2 132 ? 192.762 210.576 335.670 1.00 40.35  ? 132 PHE B CB  1 
ATOM   2735 C CG  . PHE B 2 132 ? 192.226 211.419 334.557 1.00 45.63  ? 132 PHE B CG  1 
ATOM   2736 C CD1 . PHE B 2 132 ? 191.565 212.603 334.827 1.00 46.25  ? 132 PHE B CD1 1 
ATOM   2737 C CD2 . PHE B 2 132 ? 192.386 211.035 333.241 1.00 44.78  ? 132 PHE B CD2 1 
ATOM   2738 C CE1 . PHE B 2 132 ? 191.075 213.384 333.811 1.00 43.96  ? 132 PHE B CE1 1 
ATOM   2739 C CE2 . PHE B 2 132 ? 191.897 211.815 332.220 1.00 47.80  ? 132 PHE B CE2 1 
ATOM   2740 C CZ  . PHE B 2 132 ? 191.241 212.992 332.508 1.00 49.25  ? 132 PHE B CZ  1 
ATOM   2741 N N   . TYR B 2 133 ? 194.598 211.715 338.494 1.00 37.05  ? 133 TYR B N   1 
ATOM   2742 C CA  . TYR B 2 133 ? 194.647 211.578 339.942 1.00 37.35  ? 133 TYR B CA  1 
ATOM   2743 C C   . TYR B 2 133 ? 193.361 212.138 340.529 1.00 50.89  ? 133 TYR B C   1 
ATOM   2744 O O   . TYR B 2 133 ? 192.983 213.274 340.225 1.00 64.57  ? 133 TYR B O   1 
ATOM   2745 C CB  . TYR B 2 133 ? 195.847 212.323 340.528 1.00 44.80  ? 133 TYR B CB  1 
ATOM   2746 C CG  . TYR B 2 133 ? 197.175 211.973 339.903 1.00 48.01  ? 133 TYR B CG  1 
ATOM   2747 C CD1 . TYR B 2 133 ? 197.911 210.889 340.354 1.00 49.96  ? 133 TYR B CD1 1 
ATOM   2748 C CD2 . TYR B 2 133 ? 197.701 212.736 338.874 1.00 47.97  ? 133 TYR B CD2 1 
ATOM   2749 C CE1 . TYR B 2 133 ? 199.127 210.571 339.791 1.00 51.80  ? 133 TYR B CE1 1 
ATOM   2750 C CE2 . TYR B 2 133 ? 198.916 212.425 338.304 1.00 42.17  ? 133 TYR B CE2 1 
ATOM   2751 C CZ  . TYR B 2 133 ? 199.624 211.342 338.767 1.00 47.74  ? 133 TYR B CZ  1 
ATOM   2752 O OH  . TYR B 2 133 ? 200.836 211.027 338.202 1.00 56.42  ? 133 TYR B OH  1 
ATOM   2753 N N   . THR B 2 134 ? 192.694 211.346 341.365 1.00 50.40  ? 134 THR B N   1 
ATOM   2754 C CA  . THR B 2 134 ? 191.455 211.766 342.011 1.00 47.52  ? 134 THR B CA  1 
ATOM   2755 C C   . THR B 2 134 ? 191.792 212.383 343.362 1.00 48.51  ? 134 THR B C   1 
ATOM   2756 O O   . THR B 2 134 ? 192.150 211.672 344.305 1.00 46.78  ? 134 THR B O   1 
ATOM   2757 C CB  . THR B 2 134 ? 190.497 210.590 342.185 1.00 48.41  ? 134 THR B CB  1 
ATOM   2758 O OG1 . THR B 2 134 ? 191.116 209.581 342.988 1.00 53.99  ? 134 THR B OG1 1 
ATOM   2759 C CG2 . THR B 2 134 ? 190.110 210.001 340.843 1.00 47.26  ? 134 THR B CG2 1 
ATOM   2760 N N   . LEU B 2 135 ? 191.672 213.702 343.457 1.00 56.30  ? 135 LEU B N   1 
ATOM   2761 C CA  . LEU B 2 135 ? 191.870 214.375 344.727 1.00 52.61  ? 135 LEU B CA  1 
ATOM   2762 C C   . LEU B 2 135 ? 190.751 213.999 345.695 1.00 59.53  ? 135 LEU B C   1 
ATOM   2763 O O   . LEU B 2 135 ? 189.728 213.424 345.315 1.00 63.62  ? 135 LEU B O   1 
ATOM   2764 C CB  . LEU B 2 135 ? 191.920 215.889 344.530 1.00 55.08  ? 135 LEU B CB  1 
ATOM   2765 C CG  . LEU B 2 135 ? 193.190 216.464 343.899 1.00 63.80  ? 135 LEU B CG  1 
ATOM   2766 C CD1 . LEU B 2 135 ? 193.409 215.942 342.486 1.00 51.82  ? 135 LEU B CD1 1 
ATOM   2767 C CD2 . LEU B 2 135 ? 193.125 217.981 343.906 1.00 63.31  ? 135 LEU B CD2 1 
ATOM   2768 N N   . ASP B 2 136 ? 190.957 214.332 346.966 1.00 65.29  ? 136 ASP B N   1 
ATOM   2769 C CA  . ASP B 2 136 ? 189.994 213.970 347.994 1.00 64.87  ? 136 ASP B CA  1 
ATOM   2770 C C   . ASP B 2 136 ? 188.608 214.506 347.649 1.00 63.93  ? 136 ASP B C   1 
ATOM   2771 O O   . ASP B 2 136 ? 188.444 215.401 346.817 1.00 61.56  ? 136 ASP B O   1 
ATOM   2772 C CB  . ASP B 2 136 ? 190.432 214.507 349.355 1.00 65.00  ? 136 ASP B CB  1 
ATOM   2773 C CG  . ASP B 2 136 ? 191.763 213.944 349.800 1.00 70.44  ? 136 ASP B CG  1 
ATOM   2774 O OD1 . ASP B 2 136 ? 192.356 213.150 349.042 1.00 75.24  ? 136 ASP B OD1 1 
ATOM   2775 O OD2 . ASP B 2 136 ? 192.216 214.295 350.909 1.00 68.28  ? 136 ASP B OD2 1 
ATOM   2776 N N   . THR B 2 137 ? 187.603 213.940 348.307 1.00 59.88  ? 137 THR B N   1 
ATOM   2777 C CA  . THR B 2 137 ? 186.214 214.311 348.094 1.00 59.72  ? 137 THR B CA  1 
ATOM   2778 C C   . THR B 2 137 ? 185.766 215.293 349.169 1.00 59.63  ? 137 THR B C   1 
ATOM   2779 O O   . THR B 2 137 ? 186.278 215.290 350.291 1.00 60.02  ? 137 THR B O   1 
ATOM   2780 C CB  . THR B 2 137 ? 185.316 213.074 348.111 1.00 57.77  ? 137 THR B CB  1 
ATOM   2781 O OG1 . THR B 2 137 ? 185.945 212.013 347.382 1.00 62.13  ? 137 THR B OG1 1 
ATOM   2782 C CG2 . THR B 2 137 ? 183.984 213.380 347.473 1.00 52.83  ? 137 THR B CG2 1 
ATOM   2783 N N   . VAL B 2 138 ? 184.801 216.137 348.813 1.00 59.07  ? 138 VAL B N   1 
ATOM   2784 C CA  . VAL B 2 138 ? 184.320 217.202 349.683 1.00 52.77  ? 138 VAL B CA  1 
ATOM   2785 C C   . VAL B 2 138 ? 182.799 217.191 349.683 1.00 54.83  ? 138 VAL B C   1 
ATOM   2786 O O   . VAL B 2 138 ? 182.169 217.058 348.628 1.00 57.88  ? 138 VAL B O   1 
ATOM   2787 C CB  . VAL B 2 138 ? 184.853 218.578 349.237 1.00 56.06  ? 138 VAL B CB  1 
ATOM   2788 C CG1 . VAL B 2 138 ? 186.354 218.649 349.445 1.00 59.42  ? 138 VAL B CG1 1 
ATOM   2789 C CG2 . VAL B 2 138 ? 184.505 218.838 347.781 1.00 58.42  ? 138 VAL B CG2 1 
ATOM   2790 N N   . SER B 2 139 ? 182.212 217.330 350.869 1.00 59.47  ? 139 SER B N   1 
ATOM   2791 C CA  . SER B 2 139 ? 180.763 217.303 351.013 1.00 60.83  ? 139 SER B CA  1 
ATOM   2792 C C   . SER B 2 139 ? 180.172 218.669 350.694 1.00 56.59  ? 139 SER B C   1 
ATOM   2793 O O   . SER B 2 139 ? 180.613 219.688 351.234 1.00 61.32  ? 139 SER B O   1 
ATOM   2794 C CB  . SER B 2 139 ? 180.381 216.886 352.431 1.00 62.56  ? 139 SER B CB  1 
ATOM   2795 O OG  . SER B 2 139 ? 180.736 215.538 352.678 1.00 67.37  ? 139 SER B OG  1 
ATOM   2796 N N   . TRP B 2 140 ? 179.170 218.686 349.819 1.00 46.82  ? 140 TRP B N   1 
ATOM   2797 C CA  . TRP B 2 140 ? 178.484 219.921 349.445 1.00 47.35  ? 140 TRP B CA  1 
ATOM   2798 C C   . TRP B 2 140 ? 177.211 220.071 350.277 1.00 54.08  ? 140 TRP B C   1 
ATOM   2799 O O   . TRP B 2 140 ? 176.088 219.957 349.789 1.00 53.99  ? 140 TRP B O   1 
ATOM   2800 C CB  . TRP B 2 140 ? 178.182 219.922 347.950 1.00 46.08  ? 140 TRP B CB  1 
ATOM   2801 C CG  . TRP B 2 140 ? 177.384 221.104 347.477 1.00 42.55  ? 140 TRP B CG  1 
ATOM   2802 C CD1 . TRP B 2 140 ? 177.142 222.260 348.157 1.00 51.17  ? 140 TRP B CD1 1 
ATOM   2803 C CD2 . TRP B 2 140 ? 176.719 221.235 346.217 1.00 44.10  ? 140 TRP B CD2 1 
ATOM   2804 N NE1 . TRP B 2 140 ? 176.370 223.103 347.399 1.00 57.71  ? 140 TRP B NE1 1 
ATOM   2805 C CE2 . TRP B 2 140 ? 176.097 222.496 346.202 1.00 52.33  ? 140 TRP B CE2 1 
ATOM   2806 C CE3 . TRP B 2 140 ? 176.592 220.409 345.100 1.00 42.80  ? 140 TRP B CE3 1 
ATOM   2807 C CZ2 . TRP B 2 140 ? 175.359 222.949 345.116 1.00 54.71  ? 140 TRP B CZ2 1 
ATOM   2808 C CZ3 . TRP B 2 140 ? 175.859 220.860 344.024 1.00 42.84  ? 140 TRP B CZ3 1 
ATOM   2809 C CH2 . TRP B 2 140 ? 175.253 222.118 344.038 1.00 50.66  ? 140 TRP B CH2 1 
ATOM   2810 N N   . THR B 2 141 ? 177.411 220.337 351.564 1.00 67.53  ? 141 THR B N   1 
ATOM   2811 C CA  . THR B 2 141 ? 176.283 220.615 352.434 1.00 61.77  ? 141 THR B CA  1 
ATOM   2812 C C   . THR B 2 141 ? 175.567 221.879 351.964 1.00 61.96  ? 141 THR B C   1 
ATOM   2813 O O   . THR B 2 141 ? 176.050 222.620 351.106 1.00 67.64  ? 141 THR B O   1 
ATOM   2814 C CB  . THR B 2 141 ? 176.744 220.771 353.880 1.00 66.52  ? 141 THR B CB  1 
ATOM   2815 O OG1 . THR B 2 141 ? 177.696 221.838 353.969 1.00 66.53  ? 141 THR B OG1 1 
ATOM   2816 C CG2 . THR B 2 141 ? 177.379 219.484 354.378 1.00 66.31  ? 141 THR B CG2 1 
ATOM   2817 N N   . LYS B 2 142 ? 174.389 222.121 352.540 1.00 65.52  ? 142 LYS B N   1 
ATOM   2818 C CA  . LYS B 2 142 ? 173.597 223.271 352.119 1.00 70.89  ? 142 LYS B CA  1 
ATOM   2819 C C   . LYS B 2 142 ? 174.332 224.577 352.393 1.00 74.83  ? 142 LYS B C   1 
ATOM   2820 O O   . LYS B 2 142 ? 174.348 225.477 351.546 1.00 69.96  ? 142 LYS B O   1 
ATOM   2821 C CB  . LYS B 2 142 ? 172.241 223.258 352.824 1.00 69.02  ? 142 LYS B CB  1 
ATOM   2822 C CG  . LYS B 2 142 ? 171.279 224.332 352.335 1.00 71.22  ? 142 LYS B CG  1 
ATOM   2823 C CD  . LYS B 2 142 ? 169.966 224.313 353.105 1.00 73.64  ? 142 LYS B CD  1 
ATOM   2824 C CE  . LYS B 2 142 ? 169.143 223.069 352.809 1.00 72.14  ? 142 LYS B CE  1 
ATOM   2825 N NZ  . LYS B 2 142 ? 168.774 222.965 351.371 1.00 73.07  ? 142 LYS B NZ  1 
ATOM   2826 N N   . GLU B 2 143 ? 174.943 224.700 353.567 1.00 78.09  ? 143 GLU B N   1 
ATOM   2827 C CA  . GLU B 2 143 ? 175.636 225.927 353.962 1.00 73.85  ? 143 GLU B CA  1 
ATOM   2828 C C   . GLU B 2 143 ? 177.139 225.814 353.706 1.00 75.79  ? 143 GLU B C   1 
ATOM   2829 O O   . GLU B 2 143 ? 177.964 225.942 354.610 1.00 77.83  ? 143 GLU B O   1 
ATOM   2830 C CB  . GLU B 2 143 ? 175.348 226.250 355.426 1.00 75.78  ? 143 GLU B CB  1 
ATOM   2831 C CG  . GLU B 2 143 ? 175.738 225.158 356.417 1.00 79.46  ? 143 GLU B CG  1 
ATOM   2832 C CD  . GLU B 2 143 ? 174.678 224.085 356.561 1.00 81.87  ? 143 GLU B CD  1 
ATOM   2833 O OE1 . GLU B 2 143 ? 173.650 224.164 355.857 1.00 81.63  ? 143 GLU B OE1 1 
ATOM   2834 O OE2 . GLU B 2 143 ? 174.875 223.161 357.377 1.00 80.78  ? 143 GLU B OE2 1 
ATOM   2835 N N   . SER B 2 144 ? 177.494 225.574 352.447 1.00 66.44  ? 144 SER B N   1 
ATOM   2836 C CA  . SER B 2 144 ? 178.883 225.556 352.007 1.00 63.64  ? 144 SER B CA  1 
ATOM   2837 C C   . SER B 2 144 ? 179.047 226.569 350.885 1.00 62.22  ? 144 SER B C   1 
ATOM   2838 O O   . SER B 2 144 ? 178.218 226.623 349.971 1.00 62.78  ? 144 SER B O   1 
ATOM   2839 C CB  . SER B 2 144 ? 179.302 224.165 351.534 1.00 61.25  ? 144 SER B CB  1 
ATOM   2840 O OG  . SER B 2 144 ? 178.668 223.834 350.314 1.00 64.25  ? 144 SER B OG  1 
ATOM   2841 N N   . ARG B 2 145 ? 180.114 227.362 350.953 1.00 56.91  ? 145 ARG B N   1 
ATOM   2842 C CA  . ARG B 2 145 ? 180.273 228.503 350.060 1.00 58.17  ? 145 ARG B CA  1 
ATOM   2843 C C   . ARG B 2 145 ? 181.143 228.219 348.846 1.00 56.95  ? 145 ARG B C   1 
ATOM   2844 O O   . ARG B 2 145 ? 180.962 228.867 347.812 1.00 56.65  ? 145 ARG B O   1 
ATOM   2845 C CB  . ARG B 2 145 ? 180.863 229.691 350.826 1.00 61.63  ? 145 ARG B CB  1 
ATOM   2846 C CG  . ARG B 2 145 ? 180.080 230.082 352.072 1.00 59.97  ? 145 ARG B CG  1 
ATOM   2847 C CD  . ARG B 2 145 ? 178.582 230.073 351.819 1.00 62.16  ? 145 ARG B CD  1 
ATOM   2848 N NE  . ARG B 2 145 ? 177.842 230.839 352.816 1.00 66.14  ? 145 ARG B NE  1 
ATOM   2849 C CZ  . ARG B 2 145 ? 177.441 232.094 352.661 1.00 66.82  ? 145 ARG B CZ  1 
ATOM   2850 N NH1 . ARG B 2 145 ? 177.693 232.772 351.552 1.00 69.29  ? 145 ARG B NH1 1 
ATOM   2851 N NH2 . ARG B 2 145 ? 176.768 232.685 353.644 1.00 64.60  ? 145 ARG B NH2 1 
ATOM   2852 N N   . GLY B 2 146 ? 182.078 227.287 348.933 1.00 48.68  ? 146 GLY B N   1 
ATOM   2853 C CA  . GLY B 2 146 ? 182.896 226.960 347.784 1.00 53.28  ? 146 GLY B CA  1 
ATOM   2854 C C   . GLY B 2 146 ? 184.224 226.371 348.202 1.00 56.02  ? 146 GLY B C   1 
ATOM   2855 O O   . GLY B 2 146 ? 184.527 226.223 349.386 1.00 57.69  ? 146 GLY B O   1 
ATOM   2856 N N   . TRP B 2 147 ? 185.015 226.032 347.186 1.00 52.06  ? 147 TRP B N   1 
ATOM   2857 C CA  . TRP B 2 147 ? 186.323 225.429 347.389 1.00 50.46  ? 147 TRP B CA  1 
ATOM   2858 C C   . TRP B 2 147 ? 187.252 225.908 346.286 1.00 49.11  ? 147 TRP B C   1 
ATOM   2859 O O   . TRP B 2 147 ? 186.805 226.335 345.220 1.00 53.67  ? 147 TRP B O   1 
ATOM   2860 C CB  . TRP B 2 147 ? 186.242 223.898 347.389 1.00 51.72  ? 147 TRP B CB  1 
ATOM   2861 C CG  . TRP B 2 147 ? 185.165 223.348 348.272 1.00 51.27  ? 147 TRP B CG  1 
ATOM   2862 C CD1 . TRP B 2 147 ? 185.309 222.870 349.539 1.00 53.49  ? 147 TRP B CD1 1 
ATOM   2863 C CD2 . TRP B 2 147 ? 183.775 223.222 347.951 1.00 52.11  ? 147 TRP B CD2 1 
ATOM   2864 N NE1 . TRP B 2 147 ? 184.095 222.454 350.028 1.00 59.03  ? 147 TRP B NE1 1 
ATOM   2865 C CE2 . TRP B 2 147 ? 183.137 222.659 349.072 1.00 50.33  ? 147 TRP B CE2 1 
ATOM   2866 C CE3 . TRP B 2 147 ? 183.008 223.532 346.825 1.00 51.84  ? 147 TRP B CE3 1 
ATOM   2867 C CZ2 . TRP B 2 147 ? 181.772 222.401 349.100 1.00 47.44  ? 147 TRP B CZ2 1 
ATOM   2868 C CZ3 . TRP B 2 147 ? 181.653 223.273 346.855 1.00 52.99  ? 147 TRP B CZ3 1 
ATOM   2869 C CH2 . TRP B 2 147 ? 181.048 222.713 347.984 1.00 53.74  ? 147 TRP B CH2 1 
ATOM   2870 N N   . TRP B 2 148 ? 188.555 225.841 346.550 1.00 52.31  ? 148 TRP B N   1 
ATOM   2871 C CA  . TRP B 2 148 ? 189.539 226.238 345.551 1.00 52.91  ? 148 TRP B CA  1 
ATOM   2872 C C   . TRP B 2 148 ? 190.814 225.428 345.720 1.00 55.55  ? 148 TRP B C   1 
ATOM   2873 O O   . TRP B 2 148 ? 191.351 225.331 346.827 1.00 52.88  ? 148 TRP B O   1 
ATOM   2874 C CB  . TRP B 2 148 ? 189.847 227.737 345.639 1.00 52.55  ? 148 TRP B CB  1 
ATOM   2875 C CG  . TRP B 2 148 ? 190.341 228.193 346.973 1.00 47.61  ? 148 TRP B CG  1 
ATOM   2876 C CD1 . TRP B 2 148 ? 189.585 228.630 348.018 1.00 49.63  ? 148 TRP B CD1 1 
ATOM   2877 C CD2 . TRP B 2 148 ? 191.703 228.274 347.402 1.00 52.47  ? 148 TRP B CD2 1 
ATOM   2878 N NE1 . TRP B 2 148 ? 190.390 228.972 349.075 1.00 52.10  ? 148 TRP B NE1 1 
ATOM   2879 C CE2 . TRP B 2 148 ? 191.697 228.766 348.721 1.00 54.78  ? 148 TRP B CE2 1 
ATOM   2880 C CE3 . TRP B 2 148 ? 192.929 227.977 346.801 1.00 56.46  ? 148 TRP B CE3 1 
ATOM   2881 C CZ2 . TRP B 2 148 ? 192.864 228.961 349.450 1.00 54.49  ? 148 TRP B CZ2 1 
ATOM   2882 C CZ3 . TRP B 2 148 ? 194.087 228.174 347.525 1.00 55.08  ? 148 TRP B CZ3 1 
ATOM   2883 C CH2 . TRP B 2 148 ? 194.047 228.661 348.835 1.00 51.74  ? 148 TRP B CH2 1 
ATOM   2884 N N   . TRP B 2 149 ? 191.287 224.854 344.617 1.00 57.67  ? 149 TRP B N   1 
ATOM   2885 C CA  . TRP B 2 149 ? 192.536 224.104 344.573 1.00 50.88  ? 149 TRP B CA  1 
ATOM   2886 C C   . TRP B 2 149 ? 193.465 224.748 343.557 1.00 54.94  ? 149 TRP B C   1 
ATOM   2887 O O   . TRP B 2 149 ? 193.084 224.938 342.400 1.00 60.67  ? 149 TRP B O   1 
ATOM   2888 C CB  . TRP B 2 149 ? 192.300 222.642 344.187 1.00 55.33  ? 149 TRP B CB  1 
ATOM   2889 C CG  . TRP B 2 149 ? 191.351 221.909 345.072 1.00 52.42  ? 149 TRP B CG  1 
ATOM   2890 C CD1 . TRP B 2 149 ? 191.666 221.139 346.147 1.00 54.37  ? 149 TRP B CD1 1 
ATOM   2891 C CD2 . TRP B 2 149 ? 189.928 221.865 344.949 1.00 47.52  ? 149 TRP B CD2 1 
ATOM   2892 N NE1 . TRP B 2 149 ? 190.527 220.622 346.708 1.00 52.34  ? 149 TRP B NE1 1 
ATOM   2893 C CE2 . TRP B 2 149 ? 189.445 221.053 345.989 1.00 46.98  ? 149 TRP B CE2 1 
ATOM   2894 C CE3 . TRP B 2 149 ? 189.015 222.437 344.061 1.00 53.08  ? 149 TRP B CE3 1 
ATOM   2895 C CZ2 . TRP B 2 149 ? 188.091 220.799 346.167 1.00 52.50  ? 149 TRP B CZ2 1 
ATOM   2896 C CZ3 . TRP B 2 149 ? 187.673 222.183 344.238 1.00 59.74  ? 149 TRP B CZ3 1 
ATOM   2897 C CH2 . TRP B 2 149 ? 187.223 221.371 345.283 1.00 56.69  ? 149 TRP B CH2 1 
ATOM   2898 N N   . LYS B 2 150 ? 194.683 225.065 343.978 1.00 56.91  ? 150 LYS B N   1 
ATOM   2899 C CA  . LYS B 2 150 ? 195.670 225.637 343.077 1.00 51.42  ? 150 LYS B CA  1 
ATOM   2900 C C   . LYS B 2 150 ? 196.471 224.528 342.411 1.00 48.16  ? 150 LYS B C   1 
ATOM   2901 O O   . LYS B 2 150 ? 196.788 223.514 343.038 1.00 57.50  ? 150 LYS B O   1 
ATOM   2902 C CB  . LYS B 2 150 ? 196.605 226.583 343.829 1.00 49.03  ? 150 LYS B CB  1 
ATOM   2903 C CG  . LYS B 2 150 ? 195.934 227.852 344.319 1.00 51.30  ? 150 LYS B CG  1 
ATOM   2904 C CD  . LYS B 2 150 ? 196.934 228.769 344.995 1.00 61.12  ? 150 LYS B CD  1 
ATOM   2905 C CE  . LYS B 2 150 ? 196.326 230.119 345.326 1.00 52.14  ? 150 LYS B CE  1 
ATOM   2906 N NZ  . LYS B 2 150 ? 197.321 231.032 345.950 1.00 50.55  ? 150 LYS B NZ  1 
ATOM   2907 N N   . LEU B 2 151 ? 196.793 224.726 341.135 1.00 45.52  ? 151 LEU B N   1 
ATOM   2908 C CA  . LEU B 2 151 ? 197.546 223.754 340.362 1.00 48.97  ? 151 LEU B CA  1 
ATOM   2909 C C   . LEU B 2 151 ? 198.871 224.353 339.906 1.00 52.90  ? 151 LEU B C   1 
ATOM   2910 O O   . LEU B 2 151 ? 198.946 225.552 339.624 1.00 60.55  ? 151 LEU B O   1 
ATOM   2911 C CB  . LEU B 2 151 ? 196.753 223.294 339.134 1.00 46.19  ? 151 LEU B CB  1 
ATOM   2912 C CG  . LEU B 2 151 ? 195.345 222.772 339.406 1.00 47.64  ? 151 LEU B CG  1 
ATOM   2913 C CD1 . LEU B 2 151 ? 194.591 222.597 338.104 1.00 50.80  ? 151 LEU B CD1 1 
ATOM   2914 C CD2 . LEU B 2 151 ? 195.396 221.465 340.168 1.00 49.33  ? 151 LEU B CD2 1 
ATOM   2915 N N   . PRO B 2 152 ? 199.937 223.546 339.815 1.00 44.82  ? 152 PRO B N   1 
ATOM   2916 C CA  . PRO B 2 152 ? 200.020 222.108 340.103 1.00 49.54  ? 152 PRO B CA  1 
ATOM   2917 C C   . PRO B 2 152 ? 200.238 221.820 341.579 1.00 49.95  ? 152 PRO B C   1 
ATOM   2918 O O   . PRO B 2 152 ? 200.573 220.703 341.950 1.00 52.70  ? 152 PRO B O   1 
ATOM   2919 C CB  . PRO B 2 152 ? 201.221 221.667 339.265 1.00 55.64  ? 152 PRO B CB  1 
ATOM   2920 C CG  . PRO B 2 152 ? 202.119 222.859 339.279 1.00 57.46  ? 152 PRO B CG  1 
ATOM   2921 C CD  . PRO B 2 152 ? 201.204 224.058 339.266 1.00 48.22  ? 152 PRO B CD  1 
ATOM   2922 N N   . ASP B 2 153 ? 200.054 222.815 342.447 1.00 48.79  ? 153 ASP B N   1 
ATOM   2923 C CA  . ASP B 2 153 ? 200.296 222.599 343.867 1.00 53.82  ? 153 ASP B CA  1 
ATOM   2924 C C   . ASP B 2 153 ? 199.447 221.463 344.415 1.00 52.52  ? 153 ASP B C   1 
ATOM   2925 O O   . ASP B 2 153 ? 199.828 220.828 345.404 1.00 65.74  ? 153 ASP B O   1 
ATOM   2926 C CB  . ASP B 2 153 ? 200.023 223.884 344.644 1.00 63.79  ? 153 ASP B CB  1 
ATOM   2927 C CG  . ASP B 2 153 ? 200.191 223.707 346.137 1.00 66.71  ? 153 ASP B CG  1 
ATOM   2928 O OD1 . ASP B 2 153 ? 201.273 223.254 346.565 1.00 60.69  ? 153 ASP B OD1 1 
ATOM   2929 O OD2 . ASP B 2 153 ? 199.244 224.029 346.884 1.00 68.45  ? 153 ASP B OD2 1 
ATOM   2930 N N   . ALA B 2 154 ? 198.296 221.192 343.798 1.00 45.17  ? 154 ALA B N   1 
ATOM   2931 C CA  . ALA B 2 154 ? 197.473 220.074 344.246 1.00 52.54  ? 154 ALA B CA  1 
ATOM   2932 C C   . ALA B 2 154 ? 198.150 218.740 343.956 1.00 52.42  ? 154 ALA B C   1 
ATOM   2933 O O   . ALA B 2 154 ? 198.146 217.838 344.801 1.00 43.57  ? 154 ALA B O   1 
ATOM   2934 C CB  . ALA B 2 154 ? 196.101 220.132 343.579 1.00 52.53  ? 154 ALA B CB  1 
ATOM   2935 N N   . LEU B 2 155 ? 198.734 218.597 342.771 1.00 54.80  ? 155 LEU B N   1 
ATOM   2936 C CA  . LEU B 2 155 ? 199.419 217.366 342.382 1.00 52.46  ? 155 LEU B CA  1 
ATOM   2937 C C   . LEU B 2 155 ? 200.888 217.400 342.786 1.00 51.18  ? 155 LEU B C   1 
ATOM   2938 O O   . LEU B 2 155 ? 201.778 217.180 341.968 1.00 52.40  ? 155 LEU B O   1 
ATOM   2939 C CB  . LEU B 2 155 ? 199.279 217.150 340.881 1.00 52.02  ? 155 LEU B CB  1 
ATOM   2940 C CG  . LEU B 2 155 ? 197.905 217.403 340.266 1.00 48.23  ? 155 LEU B CG  1 
ATOM   2941 C CD1 . LEU B 2 155 ? 197.992 217.307 338.758 1.00 48.79  ? 155 LEU B CD1 1 
ATOM   2942 C CD2 . LEU B 2 155 ? 196.885 216.423 340.804 1.00 55.60  ? 155 LEU B CD2 1 
ATOM   2943 N N   . ARG B 2 156 ? 201.155 217.683 344.058 1.00 54.24  ? 156 ARG B N   1 
ATOM   2944 C CA  . ARG B 2 156 ? 202.520 217.698 344.567 1.00 55.12  ? 156 ARG B CA  1 
ATOM   2945 C C   . ARG B 2 156 ? 202.886 216.421 345.303 1.00 56.65  ? 156 ARG B C   1 
ATOM   2946 O O   . ARG B 2 156 ? 204.069 216.073 345.368 1.00 60.05  ? 156 ARG B O   1 
ATOM   2947 C CB  . ARG B 2 156 ? 202.726 218.896 345.498 1.00 54.04  ? 156 ARG B CB  1 
ATOM   2948 C CG  . ARG B 2 156 ? 201.974 218.805 346.808 1.00 56.28  ? 156 ARG B CG  1 
ATOM   2949 C CD  . ARG B 2 156 ? 202.080 220.099 347.591 1.00 52.54  ? 156 ARG B CD  1 
ATOM   2950 N NE  . ARG B 2 156 ? 201.554 219.958 348.942 1.00 60.52  ? 156 ARG B NE  1 
ATOM   2951 C CZ  . ARG B 2 156 ? 201.355 220.968 349.778 1.00 63.01  ? 156 ARG B CZ  1 
ATOM   2952 N NH1 . ARG B 2 156 ? 201.609 222.217 349.426 1.00 59.60  ? 156 ARG B NH1 1 
ATOM   2953 N NH2 . ARG B 2 156 ? 200.886 220.717 350.996 1.00 62.53  ? 156 ARG B NH2 1 
ATOM   2954 N N   . ASP B 2 157 ? 201.904 215.721 345.855 1.00 62.55  ? 157 ASP B N   1 
ATOM   2955 C CA  . ASP B 2 157 ? 202.095 214.420 346.479 1.00 66.70  ? 157 ASP B CA  1 
ATOM   2956 C C   . ASP B 2 157 ? 201.219 213.378 345.795 1.00 67.32  ? 157 ASP B C   1 
ATOM   2957 O O   . ASP B 2 157 ? 200.593 212.536 346.441 1.00 61.86  ? 157 ASP B O   1 
ATOM   2958 C CB  . ASP B 2 157 ? 201.805 214.488 347.976 1.00 67.17  ? 157 ASP B CB  1 
ATOM   2959 C CG  . ASP B 2 157 ? 200.624 215.380 348.301 1.00 72.19  ? 157 ASP B CG  1 
ATOM   2960 O OD1 . ASP B 2 157 ? 200.051 215.973 347.364 1.00 73.62  ? 157 ASP B OD1 1 
ATOM   2961 O OD2 . ASP B 2 157 ? 200.272 215.492 349.494 1.00 70.72  ? 157 ASP B OD2 1 
ATOM   2962 N N   . MET B 2 158 ? 201.166 213.437 344.467 1.00 58.85  ? 158 MET B N   1 
ATOM   2963 C CA  . MET B 2 158 ? 200.369 212.526 343.650 1.00 53.49  ? 158 MET B CA  1 
ATOM   2964 C C   . MET B 2 158 ? 201.313 211.775 342.719 1.00 54.58  ? 158 MET B C   1 
ATOM   2965 O O   . MET B 2 158 ? 201.760 212.322 341.706 1.00 56.76  ? 158 MET B O   1 
ATOM   2966 C CB  . MET B 2 158 ? 199.311 213.286 342.855 1.00 56.31  ? 158 MET B CB  1 
ATOM   2967 C CG  . MET B 2 158 ? 198.136 213.778 343.675 1.00 60.33  ? 158 MET B CG  1 
ATOM   2968 S SD  . MET B 2 158 ? 197.090 212.440 344.266 1.00 64.59  ? 158 MET B SD  1 
ATOM   2969 C CE  . MET B 2 158 ? 195.698 213.366 344.897 1.00 57.01  ? 158 MET B CE  1 
ATOM   2970 N N   . GLY B 2 159 ? 201.618 210.529 343.064 1.00 58.83  ? 159 GLY B N   1 
ATOM   2971 C CA  . GLY B 2 159 ? 202.361 209.671 342.165 1.00 57.94  ? 159 GLY B CA  1 
ATOM   2972 C C   . GLY B 2 159 ? 203.704 210.259 341.780 1.00 53.91  ? 159 GLY B C   1 
ATOM   2973 O O   . GLY B 2 159 ? 204.351 210.977 342.548 1.00 58.61  ? 159 GLY B O   1 
ATOM   2974 N N   . LEU B 2 160 ? 204.128 209.951 340.553 1.00 42.44  ? 160 LEU B N   1 
ATOM   2975 C CA  . LEU B 2 160 ? 205.431 210.385 340.071 1.00 47.02  ? 160 LEU B CA  1 
ATOM   2976 C C   . LEU B 2 160 ? 205.444 211.833 339.606 1.00 53.02  ? 160 LEU B C   1 
ATOM   2977 O O   . LEU B 2 160 ? 206.526 212.399 339.431 1.00 59.04  ? 160 LEU B O   1 
ATOM   2978 C CB  . LEU B 2 160 ? 205.894 209.487 338.922 1.00 46.04  ? 160 LEU B CB  1 
ATOM   2979 C CG  . LEU B 2 160 ? 206.848 208.348 339.280 1.00 44.45  ? 160 LEU B CG  1 
ATOM   2980 C CD1 . LEU B 2 160 ? 207.054 207.444 338.082 1.00 46.98  ? 160 LEU B CD1 1 
ATOM   2981 C CD2 . LEU B 2 160 ? 208.176 208.894 339.766 1.00 44.87  ? 160 LEU B CD2 1 
ATOM   2982 N N   . PHE B 2 161 ? 204.279 212.444 339.387 1.00 44.31  ? 161 PHE B N   1 
ATOM   2983 C CA  . PHE B 2 161 ? 204.260 213.850 338.997 1.00 38.89  ? 161 PHE B CA  1 
ATOM   2984 C C   . PHE B 2 161 ? 204.843 214.726 340.097 1.00 40.95  ? 161 PHE B C   1 
ATOM   2985 O O   . PHE B 2 161 ? 205.616 215.652 339.822 1.00 47.04  ? 161 PHE B O   1 
ATOM   2986 C CB  . PHE B 2 161 ? 202.834 214.284 338.666 1.00 49.53  ? 161 PHE B CB  1 
ATOM   2987 C CG  . PHE B 2 161 ? 202.731 215.695 338.164 1.00 43.39  ? 161 PHE B CG  1 
ATOM   2988 C CD1 . PHE B 2 161 ? 202.638 216.753 339.047 1.00 38.96  ? 161 PHE B CD1 1 
ATOM   2989 C CD2 . PHE B 2 161 ? 202.723 215.961 336.809 1.00 40.23  ? 161 PHE B CD2 1 
ATOM   2990 C CE1 . PHE B 2 161 ? 202.543 218.045 338.589 1.00 41.60  ? 161 PHE B CE1 1 
ATOM   2991 C CE2 . PHE B 2 161 ? 202.627 217.253 336.347 1.00 42.68  ? 161 PHE B CE2 1 
ATOM   2992 C CZ  . PHE B 2 161 ? 202.537 218.294 337.238 1.00 47.92  ? 161 PHE B CZ  1 
ATOM   2993 N N   . GLY B 2 162 ? 204.481 214.452 341.350 1.00 39.48  ? 162 GLY B N   1 
ATOM   2994 C CA  . GLY B 2 162 ? 205.069 215.192 342.452 1.00 45.41  ? 162 GLY B CA  1 
ATOM   2995 C C   . GLY B 2 162 ? 206.574 215.034 342.507 1.00 50.16  ? 162 GLY B C   1 
ATOM   2996 O O   . GLY B 2 162 ? 207.307 216.011 342.693 1.00 54.22  ? 162 GLY B O   1 
ATOM   2997 N N   . GLN B 2 163 ? 207.057 213.802 342.337 1.00 44.59  ? 163 GLN B N   1 
ATOM   2998 C CA  . GLN B 2 163 ? 208.494 213.558 342.364 1.00 45.12  ? 163 GLN B CA  1 
ATOM   2999 C C   . GLN B 2 163 ? 209.192 214.321 341.250 1.00 43.40  ? 163 GLN B C   1 
ATOM   3000 O O   . GLN B 2 163 ? 210.234 214.945 341.467 1.00 48.45  ? 163 GLN B O   1 
ATOM   3001 C CB  . GLN B 2 163 ? 208.777 212.060 342.241 1.00 44.83  ? 163 GLN B CB  1 
ATOM   3002 C CG  . GLN B 2 163 ? 207.953 211.188 343.167 1.00 44.40  ? 163 GLN B CG  1 
ATOM   3003 C CD  . GLN B 2 163 ? 208.016 211.646 344.602 1.00 47.72  ? 163 GLN B CD  1 
ATOM   3004 O OE1 . GLN B 2 163 ? 209.034 212.166 345.054 1.00 44.79  ? 163 GLN B OE1 1 
ATOM   3005 N NE2 . GLN B 2 163 ? 206.922 211.463 345.330 1.00 49.61  ? 163 GLN B NE2 1 
ATOM   3006 N N   . ASN B 2 164 ? 208.629 214.283 340.043 1.00 34.47  ? 164 ASN B N   1 
ATOM   3007 C CA  . ASN B 2 164 ? 209.252 214.979 338.925 1.00 29.33  ? 164 ASN B CA  1 
ATOM   3008 C C   . ASN B 2 164 ? 209.279 216.483 339.155 1.00 45.98  ? 164 ASN B C   1 
ATOM   3009 O O   . ASN B 2 164 ? 210.292 217.137 338.886 1.00 50.66  ? 164 ASN B O   1 
ATOM   3010 C CB  . ASN B 2 164 ? 208.523 214.649 337.625 1.00 40.11  ? 164 ASN B CB  1 
ATOM   3011 C CG  . ASN B 2 164 ? 208.909 213.295 337.072 1.00 41.37  ? 164 ASN B CG  1 
ATOM   3012 O OD1 . ASN B 2 164 ? 209.947 213.150 336.431 1.00 43.78  ? 164 ASN B OD1 1 
ATOM   3013 N ND2 . ASN B 2 164 ? 208.070 212.297 337.311 1.00 49.03  ? 164 ASN B ND2 1 
ATOM   3014 N N   . MET B 2 165 ? 208.182 217.056 339.657 1.00 48.49  ? 165 MET B N   1 
ATOM   3015 C CA  . MET B 2 165 ? 208.158 218.504 339.834 1.00 47.08  ? 165 MET B CA  1 
ATOM   3016 C C   . MET B 2 165 ? 209.066 218.944 340.974 1.00 48.85  ? 165 MET B C   1 
ATOM   3017 O O   . MET B 2 165 ? 209.607 220.054 340.935 1.00 52.87  ? 165 MET B O   1 
ATOM   3018 C CB  . MET B 2 165 ? 206.732 219.000 340.071 1.00 49.29  ? 165 MET B CB  1 
ATOM   3019 C CG  . MET B 2 165 ? 206.100 218.534 341.361 1.00 59.36  ? 165 MET B CG  1 
ATOM   3020 S SD  . MET B 2 165 ? 204.556 219.392 341.721 1.00 72.12  ? 165 MET B SD  1 
ATOM   3021 C CE  . MET B 2 165 ? 205.169 220.973 342.291 1.00 49.90  ? 165 MET B CE  1 
ATOM   3022 N N   . TYR B 2 166 ? 209.245 218.106 341.997 1.00 51.19  ? 166 TYR B N   1 
ATOM   3023 C CA  . TYR B 2 166 ? 210.173 218.465 343.063 1.00 52.90  ? 166 TYR B CA  1 
ATOM   3024 C C   . TYR B 2 166 ? 211.622 218.302 342.623 1.00 52.26  ? 166 TYR B C   1 
ATOM   3025 O O   . TYR B 2 166 ? 212.473 219.130 342.967 1.00 56.29  ? 166 TYR B O   1 
ATOM   3026 C CB  . TYR B 2 166 ? 209.904 217.622 344.309 1.00 47.49  ? 166 TYR B CB  1 
ATOM   3027 C CG  . TYR B 2 166 ? 208.802 218.162 345.192 1.00 47.21  ? 166 TYR B CG  1 
ATOM   3028 C CD1 . TYR B 2 166 ? 207.795 218.958 344.673 1.00 52.79  ? 166 TYR B CD1 1 
ATOM   3029 C CD2 . TYR B 2 166 ? 208.780 217.884 346.548 1.00 46.54  ? 166 TYR B CD2 1 
ATOM   3030 C CE1 . TYR B 2 166 ? 206.792 219.454 345.475 1.00 52.84  ? 166 TYR B CE1 1 
ATOM   3031 C CE2 . TYR B 2 166 ? 207.780 218.375 347.359 1.00 54.32  ? 166 TYR B CE2 1 
ATOM   3032 C CZ  . TYR B 2 166 ? 206.789 219.161 346.817 1.00 60.24  ? 166 TYR B CZ  1 
ATOM   3033 O OH  . TYR B 2 166 ? 205.791 219.653 347.623 1.00 64.41  ? 166 TYR B OH  1 
ATOM   3034 N N   . TYR B 2 167 ? 211.926 217.243 341.874 1.00 44.14  ? 167 TYR B N   1 
ATOM   3035 C CA  . TYR B 2 167 ? 213.297 217.022 341.430 1.00 40.65  ? 167 TYR B CA  1 
ATOM   3036 C C   . TYR B 2 167 ? 213.716 218.058 340.395 1.00 40.85  ? 167 TYR B C   1 
ATOM   3037 O O   . TYR B 2 167 ? 214.782 218.672 340.514 1.00 41.90  ? 167 TYR B O   1 
ATOM   3038 C CB  . TYR B 2 167 ? 213.441 215.608 340.869 1.00 36.52  ? 167 TYR B CB  1 
ATOM   3039 C CG  . TYR B 2 167 ? 213.823 214.572 341.901 1.00 39.42  ? 167 TYR B CG  1 
ATOM   3040 C CD1 . TYR B 2 167 ? 215.147 214.387 342.267 1.00 39.38  ? 167 TYR B CD1 1 
ATOM   3041 C CD2 . TYR B 2 167 ? 212.863 213.778 342.506 1.00 47.03  ? 167 TYR B CD2 1 
ATOM   3042 C CE1 . TYR B 2 167 ? 215.501 213.444 343.208 1.00 44.22  ? 167 TYR B CE1 1 
ATOM   3043 C CE2 . TYR B 2 167 ? 213.208 212.832 343.448 1.00 42.82  ? 167 TYR B CE2 1 
ATOM   3044 C CZ  . TYR B 2 167 ? 214.527 212.670 343.795 1.00 41.64  ? 167 TYR B CZ  1 
ATOM   3045 O OH  . TYR B 2 167 ? 214.876 211.728 344.732 1.00 45.73  ? 167 TYR B OH  1 
ATOM   3046 N N   . HIS B 2 168 ? 212.887 218.275 339.379 1.00 34.72  ? 168 HIS B N   1 
ATOM   3047 C CA  . HIS B 2 168 ? 213.237 219.182 338.297 1.00 39.74  ? 168 HIS B CA  1 
ATOM   3048 C C   . HIS B 2 168 ? 212.991 220.629 338.699 1.00 40.83  ? 168 HIS B C   1 
ATOM   3049 O O   . HIS B 2 168 ? 212.026 220.938 339.401 1.00 49.64  ? 168 HIS B O   1 
ATOM   3050 C CB  . HIS B 2 168 ? 212.433 218.848 337.045 1.00 39.35  ? 168 HIS B CB  1 
ATOM   3051 C CG  . HIS B 2 168 ? 212.859 217.580 336.375 1.00 34.15  ? 168 HIS B CG  1 
ATOM   3052 N ND1 . HIS B 2 168 ? 212.687 216.340 336.948 1.00 37.34  ? 168 HIS B ND1 1 
ATOM   3053 C CD2 . HIS B 2 168 ? 213.444 217.361 335.174 1.00 42.27  ? 168 HIS B CD2 1 
ATOM   3054 C CE1 . HIS B 2 168 ? 213.151 215.412 336.132 1.00 41.36  ? 168 HIS B CE1 1 
ATOM   3055 N NE2 . HIS B 2 168 ? 213.615 216.005 335.048 1.00 40.29  ? 168 HIS B NE2 1 
ATOM   3056 N N   . TYR B 2 169 ? 213.874 221.518 338.243 1.00 37.93  ? 169 TYR B N   1 
ATOM   3057 C CA  . TYR B 2 169 ? 213.749 222.933 338.575 1.00 34.20  ? 169 TYR B CA  1 
ATOM   3058 C C   . TYR B 2 169 ? 212.581 223.567 337.831 1.00 44.01  ? 169 TYR B C   1 
ATOM   3059 O O   . TYR B 2 169 ? 211.639 224.075 338.447 1.00 43.15  ? 169 TYR B O   1 
ATOM   3060 C CB  . TYR B 2 169 ? 215.060 223.656 338.258 1.00 38.79  ? 169 TYR B CB  1 
ATOM   3061 C CG  . TYR B 2 169 ? 214.970 225.165 338.281 1.00 42.49  ? 169 TYR B CG  1 
ATOM   3062 C CD1 . TYR B 2 169 ? 214.278 225.828 339.283 1.00 41.71  ? 169 TYR B CD1 1 
ATOM   3063 C CD2 . TYR B 2 169 ? 215.596 225.928 337.306 1.00 39.55  ? 169 TYR B CD2 1 
ATOM   3064 C CE1 . TYR B 2 169 ? 214.200 227.206 339.304 1.00 41.97  ? 169 TYR B CE1 1 
ATOM   3065 C CE2 . TYR B 2 169 ? 215.525 227.305 337.320 1.00 32.92  ? 169 TYR B CE2 1 
ATOM   3066 C CZ  . TYR B 2 169 ? 214.827 227.939 338.320 1.00 38.79  ? 169 TYR B CZ  1 
ATOM   3067 O OH  . TYR B 2 169 ? 214.756 229.311 338.337 1.00 38.24  ? 169 TYR B OH  1 
ATOM   3068 N N   . LEU B 2 170 ? 212.622 223.538 336.505 1.00 51.11  ? 170 LEU B N   1 
ATOM   3069 C CA  . LEU B 2 170 ? 211.578 224.126 335.683 1.00 41.32  ? 170 LEU B CA  1 
ATOM   3070 C C   . LEU B 2 170 ? 210.612 223.051 335.214 1.00 44.15  ? 170 LEU B C   1 
ATOM   3071 O O   . LEU B 2 170 ? 211.002 221.914 334.949 1.00 47.17  ? 170 LEU B O   1 
ATOM   3072 C CB  . LEU B 2 170 ? 212.171 224.838 334.468 1.00 37.73  ? 170 LEU B CB  1 
ATOM   3073 C CG  . LEU B 2 170 ? 213.214 225.906 334.775 1.00 39.78  ? 170 LEU B CG  1 
ATOM   3074 C CD1 . LEU B 2 170 ? 213.688 226.576 333.501 1.00 48.82  ? 170 LEU B CD1 1 
ATOM   3075 C CD2 . LEU B 2 170 ? 212.648 226.928 335.739 1.00 45.78  ? 170 LEU B CD2 1 
ATOM   3076 N N   . GLY B 2 171 ? 209.344 223.428 335.099 1.00 46.02  ? 171 GLY B N   1 
ATOM   3077 C CA  . GLY B 2 171 ? 208.342 222.507 334.612 1.00 47.56  ? 171 GLY B CA  1 
ATOM   3078 C C   . GLY B 2 171 ? 207.099 223.192 334.088 1.00 37.88  ? 171 GLY B C   1 
ATOM   3079 O O   . GLY B 2 171 ? 206.581 224.122 334.711 1.00 38.04  ? 171 GLY B O   1 
ATOM   3080 N N   . ARG B 2 172 ? 206.612 222.732 332.942 1.00 38.16  ? 172 ARG B N   1 
ATOM   3081 C CA  . ARG B 2 172 ? 205.368 223.214 332.367 1.00 36.43  ? 172 ARG B CA  1 
ATOM   3082 C C   . ARG B 2 172 ? 204.424 222.040 332.173 1.00 37.57  ? 172 ARG B C   1 
ATOM   3083 O O   . ARG B 2 172 ? 204.853 220.894 332.031 1.00 44.72  ? 172 ARG B O   1 
ATOM   3084 C CB  . ARG B 2 172 ? 205.600 223.920 331.026 1.00 40.99  ? 172 ARG B CB  1 
ATOM   3085 C CG  . ARG B 2 172 ? 205.955 222.992 329.875 1.00 39.14  ? 172 ARG B CG  1 
ATOM   3086 C CD  . ARG B 2 172 ? 206.071 223.748 328.569 1.00 41.90  ? 172 ARG B CD  1 
ATOM   3087 N NE  . ARG B 2 172 ? 204.838 224.443 328.224 1.00 34.41  ? 172 ARG B NE  1 
ATOM   3088 C CZ  . ARG B 2 172 ? 204.599 225.002 327.046 1.00 39.58  ? 172 ARG B CZ  1 
ATOM   3089 N NH1 . ARG B 2 172 ? 205.481 224.949 326.065 1.00 47.12  ? 172 ARG B NH1 1 
ATOM   3090 N NH2 . ARG B 2 172 ? 203.443 225.625 326.845 1.00 46.53  ? 172 ARG B NH2 1 
ATOM   3091 N N   . SER B 2 173 ? 203.127 222.328 332.174 1.00 37.34  ? 173 SER B N   1 
ATOM   3092 C CA  . SER B 2 173 ? 202.151 221.269 331.973 1.00 38.57  ? 173 SER B CA  1 
ATOM   3093 C C   . SER B 2 173 ? 200.770 221.875 331.799 1.00 41.94  ? 173 SER B C   1 
ATOM   3094 O O   . SER B 2 173 ? 200.428 222.850 332.472 1.00 47.41  ? 173 SER B O   1 
ATOM   3095 C CB  . SER B 2 173 ? 202.150 220.296 333.159 1.00 46.00  ? 173 SER B CB  1 
ATOM   3096 O OG  . SER B 2 173 ? 201.206 219.260 332.964 1.00 54.99  ? 173 SER B OG  1 
ATOM   3097 N N   . GLY B 2 174 ? 199.985 221.294 330.891 1.00 39.57  ? 174 GLY B N   1 
ATOM   3098 C CA  . GLY B 2 174 ? 198.560 221.532 330.858 1.00 34.64  ? 174 GLY B CA  1 
ATOM   3099 C C   . GLY B 2 174 ? 197.850 220.569 331.784 1.00 37.82  ? 174 GLY B C   1 
ATOM   3100 O O   . GLY B 2 174 ? 198.452 219.678 332.373 1.00 49.26  ? 174 GLY B O   1 
ATOM   3101 N N   . TYR B 2 175 ? 196.536 220.734 331.891 1.00 36.74  ? 175 TYR B N   1 
ATOM   3102 C CA  . TYR B 2 175 ? 195.754 219.870 332.761 1.00 34.56  ? 175 TYR B CA  1 
ATOM   3103 C C   . TYR B 2 175 ? 194.430 219.524 332.103 1.00 37.83  ? 175 TYR B C   1 
ATOM   3104 O O   . TYR B 2 175 ? 193.954 220.217 331.204 1.00 44.73  ? 175 TYR B O   1 
ATOM   3105 C CB  . TYR B 2 175 ? 195.501 220.522 334.125 1.00 39.27  ? 175 TYR B CB  1 
ATOM   3106 C CG  . TYR B 2 175 ? 196.744 221.081 334.767 1.00 37.02  ? 175 TYR B CG  1 
ATOM   3107 C CD1 . TYR B 2 175 ? 197.631 220.258 335.444 1.00 41.64  ? 175 TYR B CD1 1 
ATOM   3108 C CD2 . TYR B 2 175 ? 197.032 222.433 334.697 1.00 39.16  ? 175 TYR B CD2 1 
ATOM   3109 C CE1 . TYR B 2 175 ? 198.770 220.768 336.029 1.00 46.68  ? 175 TYR B CE1 1 
ATOM   3110 C CE2 . TYR B 2 175 ? 198.165 222.952 335.278 1.00 44.66  ? 175 TYR B CE2 1 
ATOM   3111 C CZ  . TYR B 2 175 ? 199.030 222.117 335.943 1.00 49.77  ? 175 TYR B CZ  1 
ATOM   3112 O OH  . TYR B 2 175 ? 200.161 222.640 336.521 1.00 47.89  ? 175 TYR B OH  1 
ATOM   3113 N N   . THR B 2 176 ? 193.851 218.420 332.557 1.00 41.77  ? 176 THR B N   1 
ATOM   3114 C CA  . THR B 2 176 ? 192.479 218.045 332.236 1.00 39.32  ? 176 THR B CA  1 
ATOM   3115 C C   . THR B 2 176 ? 191.778 217.803 333.562 1.00 36.84  ? 176 THR B C   1 
ATOM   3116 O O   . THR B 2 176 ? 192.070 216.820 334.249 1.00 51.01  ? 176 THR B O   1 
ATOM   3117 C CB  . THR B 2 176 ? 192.427 216.801 331.351 1.00 44.63  ? 176 THR B CB  1 
ATOM   3118 O OG1 . THR B 2 176 ? 193.160 217.038 330.145 1.00 47.84  ? 176 THR B OG1 1 
ATOM   3119 C CG2 . THR B 2 176 ? 190.991 216.450 331.004 1.00 39.05  ? 176 THR B CG2 1 
ATOM   3120 N N   . VAL B 2 177 ? 190.884 218.710 333.937 1.00 36.51  ? 177 VAL B N   1 
ATOM   3121 C CA  . VAL B 2 177 ? 190.175 218.642 335.207 1.00 39.46  ? 177 VAL B CA  1 
ATOM   3122 C C   . VAL B 2 177 ? 188.775 218.115 334.945 1.00 52.78  ? 177 VAL B C   1 
ATOM   3123 O O   . VAL B 2 177 ? 188.033 218.680 334.133 1.00 63.23  ? 177 VAL B O   1 
ATOM   3124 C CB  . VAL B 2 177 ? 190.123 220.019 335.889 1.00 44.00  ? 177 VAL B CB  1 
ATOM   3125 C CG1 . VAL B 2 177 ? 189.474 219.910 337.257 1.00 47.20  ? 177 VAL B CG1 1 
ATOM   3126 C CG2 . VAL B 2 177 ? 191.516 220.607 336.002 1.00 46.75  ? 177 VAL B CG2 1 
ATOM   3127 N N   . HIS B 2 178 ? 188.413 217.034 335.627 1.00 45.71  ? 178 HIS B N   1 
ATOM   3128 C CA  . HIS B 2 178 ? 187.078 216.455 335.547 1.00 40.34  ? 178 HIS B CA  1 
ATOM   3129 C C   . HIS B 2 178 ? 186.459 216.571 336.931 1.00 41.10  ? 178 HIS B C   1 
ATOM   3130 O O   . HIS B 2 178 ? 186.913 215.919 337.876 1.00 45.11  ? 178 HIS B O   1 
ATOM   3131 C CB  . HIS B 2 178 ? 187.136 215.003 335.079 1.00 41.07  ? 178 HIS B CB  1 
ATOM   3132 C CG  . HIS B 2 178 ? 185.829 214.476 334.576 1.00 45.03  ? 178 HIS B CG  1 
ATOM   3133 N ND1 . HIS B 2 178 ? 185.198 213.387 335.138 1.00 44.90  ? 178 HIS B ND1 1 
ATOM   3134 C CD2 . HIS B 2 178 ? 185.035 214.887 333.561 1.00 48.74  ? 178 HIS B CD2 1 
ATOM   3135 C CE1 . HIS B 2 178 ? 184.071 213.151 334.491 1.00 42.10  ? 178 HIS B CE1 1 
ATOM   3136 N NE2 . HIS B 2 178 ? 183.949 214.048 333.529 1.00 49.84  ? 178 HIS B NE2 1 
ATOM   3137 N N   . VAL B 2 179 ? 185.448 217.423 337.055 1.00 46.26  ? 179 VAL B N   1 
ATOM   3138 C CA  . VAL B 2 179 ? 184.714 217.602 338.299 1.00 47.47  ? 179 VAL B CA  1 
ATOM   3139 C C   . VAL B 2 179 ? 183.476 216.727 338.231 1.00 44.78  ? 179 VAL B C   1 
ATOM   3140 O O   . VAL B 2 179 ? 182.683 216.837 337.289 1.00 49.52  ? 179 VAL B O   1 
ATOM   3141 C CB  . VAL B 2 179 ? 184.340 219.076 338.519 1.00 45.66  ? 179 VAL B CB  1 
ATOM   3142 C CG1 . VAL B 2 179 ? 183.745 219.271 339.901 1.00 47.31  ? 179 VAL B CG1 1 
ATOM   3143 C CG2 . VAL B 2 179 ? 185.556 219.959 338.329 1.00 46.82  ? 179 VAL B CG2 1 
ATOM   3144 N N   . GLN B 2 180 ? 183.314 215.854 339.221 1.00 51.18  ? 180 GLN B N   1 
ATOM   3145 C CA  . GLN B 2 180 ? 182.250 214.862 339.242 1.00 45.12  ? 180 GLN B CA  1 
ATOM   3146 C C   . GLN B 2 180 ? 181.368 215.098 340.456 1.00 46.20  ? 180 GLN B C   1 
ATOM   3147 O O   . GLN B 2 180 ? 181.860 215.138 341.589 1.00 52.50  ? 180 GLN B O   1 
ATOM   3148 C CB  . GLN B 2 180 ? 182.830 213.448 339.282 1.00 37.97  ? 180 GLN B CB  1 
ATOM   3149 C CG  . GLN B 2 180 ? 183.828 213.157 338.177 1.00 39.23  ? 180 GLN B CG  1 
ATOM   3150 C CD  . GLN B 2 180 ? 184.834 212.104 338.573 1.00 47.55  ? 180 GLN B CD  1 
ATOM   3151 O OE1 . GLN B 2 180 ? 184.662 211.412 339.575 1.00 59.10  ? 180 GLN B OE1 1 
ATOM   3152 N NE2 . GLN B 2 180 ? 185.900 211.983 337.796 1.00 50.20  ? 180 GLN B NE2 1 
ATOM   3153 N N   . CYS B 2 181 ? 180.069 215.250 340.215 1.00 42.45  ? 181 CYS B N   1 
ATOM   3154 C CA  . CYS B 2 181 ? 179.092 215.380 341.292 1.00 50.60  ? 181 CYS B CA  1 
ATOM   3155 C C   . CYS B 2 181 ? 177.743 214.967 340.737 1.00 56.39  ? 181 CYS B C   1 
ATOM   3156 O O   . CYS B 2 181 ? 177.239 215.601 339.806 1.00 64.42  ? 181 CYS B O   1 
ATOM   3157 C CB  . CYS B 2 181 ? 179.041 216.806 341.827 1.00 55.99  ? 181 CYS B CB  1 
ATOM   3158 S SG  . CYS B 2 181 ? 177.764 217.072 343.077 1.00 59.44  ? 181 CYS B SG  1 
ATOM   3159 N N   . ASN B 2 182 ? 177.160 213.916 341.303 1.00 52.90  ? 182 ASN B N   1 
ATOM   3160 C CA  . ASN B 2 182 ? 175.934 213.325 340.793 1.00 48.93  ? 182 ASN B CA  1 
ATOM   3161 C C   . ASN B 2 182 ? 174.856 213.359 341.863 1.00 53.56  ? 182 ASN B C   1 
ATOM   3162 O O   . ASN B 2 182 ? 175.126 213.099 343.040 1.00 51.89  ? 182 ASN B O   1 
ATOM   3163 C CB  . ASN B 2 182 ? 176.169 211.887 340.355 1.00 50.47  ? 182 ASN B CB  1 
ATOM   3164 C CG  . ASN B 2 182 ? 176.705 211.033 341.474 1.00 54.49  ? 182 ASN B CG  1 
ATOM   3165 O OD1 . ASN B 2 182 ? 175.969 210.634 342.375 1.00 55.27  ? 182 ASN B OD1 1 
ATOM   3166 N ND2 . ASN B 2 182 ? 177.998 210.751 341.431 1.00 57.13  ? 182 ASN B ND2 1 
ATOM   3167 N N   . ALA B 2 183 ? 173.634 213.671 341.445 1.00 46.97  ? 183 ALA B N   1 
ATOM   3168 C CA  . ALA B 2 183 ? 172.499 213.728 342.348 1.00 44.92  ? 183 ALA B CA  1 
ATOM   3169 C C   . ALA B 2 183 ? 171.276 213.166 341.642 1.00 52.40  ? 183 ALA B C   1 
ATOM   3170 O O   . ALA B 2 183 ? 171.231 213.067 340.414 1.00 53.26  ? 183 ALA B O   1 
ATOM   3171 C CB  . ALA B 2 183 ? 172.233 215.158 342.824 1.00 46.17  ? 183 ALA B CB  1 
ATOM   3172 N N   . SER B 2 184 ? 170.279 212.796 342.439 1.00 60.68  ? 184 SER B N   1 
ATOM   3173 C CA  . SER B 2 184 ? 169.062 212.210 341.904 1.00 59.68  ? 184 SER B CA  1 
ATOM   3174 C C   . SER B 2 184 ? 168.262 213.255 341.130 1.00 55.36  ? 184 SER B C   1 
ATOM   3175 O O   . SER B 2 184 ? 168.538 214.456 341.180 1.00 60.00  ? 184 SER B O   1 
ATOM   3176 C CB  . SER B 2 184 ? 168.215 211.630 343.032 1.00 56.47  ? 184 SER B CB  1 
ATOM   3177 O OG  . SER B 2 184 ? 167.995 212.599 344.040 1.00 55.83  ? 184 SER B OG  1 
ATOM   3178 N N   . LYS B 2 185 ? 167.251 212.781 340.399 1.00 51.81  ? 185 LYS B N   1 
ATOM   3179 C CA  . LYS B 2 185 ? 166.348 213.702 339.722 1.00 56.12  ? 185 LYS B CA  1 
ATOM   3180 C C   . LYS B 2 185 ? 165.617 214.600 340.707 1.00 56.81  ? 185 LYS B C   1 
ATOM   3181 O O   . LYS B 2 185 ? 165.119 215.660 340.312 1.00 57.46  ? 185 LYS B O   1 
ATOM   3182 C CB  . LYS B 2 185 ? 165.323 212.934 338.886 1.00 58.55  ? 185 LYS B CB  1 
ATOM   3183 C CG  . LYS B 2 185 ? 165.907 212.118 337.749 1.00 57.82  ? 185 LYS B CG  1 
ATOM   3184 C CD  . LYS B 2 185 ? 164.813 211.675 336.792 1.00 56.76  ? 185 LYS B CD  1 
ATOM   3185 C CE  . LYS B 2 185 ? 165.329 210.700 335.748 1.00 59.56  ? 185 LYS B CE  1 
ATOM   3186 N NZ  . LYS B 2 185 ? 165.617 209.361 336.330 1.00 61.34  ? 185 LYS B NZ  1 
ATOM   3187 N N   . PHE B 2 186 ? 165.542 214.204 341.975 1.00 53.05  ? 186 PHE B N   1 
ATOM   3188 C CA  . PHE B 2 186 ? 164.830 214.960 342.993 1.00 52.91  ? 186 PHE B CA  1 
ATOM   3189 C C   . PHE B 2 186 ? 165.721 215.946 343.733 1.00 56.89  ? 186 PHE B C   1 
ATOM   3190 O O   . PHE B 2 186 ? 165.244 216.610 344.659 1.00 60.33  ? 186 PHE B O   1 
ATOM   3191 C CB  . PHE B 2 186 ? 164.186 214.002 343.997 1.00 54.07  ? 186 PHE B CB  1 
ATOM   3192 C CG  . PHE B 2 186 ? 163.036 213.221 343.433 1.00 57.68  ? 186 PHE B CG  1 
ATOM   3193 C CD1 . PHE B 2 186 ? 163.252 212.209 342.517 1.00 55.17  ? 186 PHE B CD1 1 
ATOM   3194 C CD2 . PHE B 2 186 ? 161.740 213.498 343.821 1.00 54.11  ? 186 PHE B CD2 1 
ATOM   3195 C CE1 . PHE B 2 186 ? 162.197 211.493 341.997 1.00 56.22  ? 186 PHE B CE1 1 
ATOM   3196 C CE2 . PHE B 2 186 ? 160.682 212.785 343.305 1.00 54.14  ? 186 PHE B CE2 1 
ATOM   3197 C CZ  . PHE B 2 186 ? 160.910 211.781 342.393 1.00 56.95  ? 186 PHE B CZ  1 
ATOM   3198 N N   . HIS B 2 187 ? 166.990 216.056 343.359 1.00 63.50  ? 187 HIS B N   1 
ATOM   3199 C CA  . HIS B 2 187 ? 167.887 217.025 343.966 1.00 58.71  ? 187 HIS B CA  1 
ATOM   3200 C C   . HIS B 2 187 ? 167.875 218.324 343.173 1.00 52.18  ? 187 HIS B C   1 
ATOM   3201 O O   . HIS B 2 187 ? 167.516 218.362 341.995 1.00 53.79  ? 187 HIS B O   1 
ATOM   3202 C CB  . HIS B 2 187 ? 169.310 216.478 344.047 1.00 58.88  ? 187 HIS B CB  1 
ATOM   3203 C CG  . HIS B 2 187 ? 169.572 215.661 345.272 1.00 58.61  ? 187 HIS B CG  1 
ATOM   3204 N ND1 . HIS B 2 187 ? 169.273 214.319 345.350 1.00 55.00  ? 187 HIS B ND1 1 
ATOM   3205 C CD2 . HIS B 2 187 ? 170.106 215.998 346.470 1.00 60.68  ? 187 HIS B CD2 1 
ATOM   3206 C CE1 . HIS B 2 187 ? 169.611 213.863 346.543 1.00 58.11  ? 187 HIS B CE1 1 
ATOM   3207 N NE2 . HIS B 2 187 ? 170.119 214.863 347.241 1.00 65.32  ? 187 HIS B NE2 1 
ATOM   3208 N N   . GLN B 2 188 ? 168.284 219.398 343.842 1.00 55.13  ? 188 GLN B N   1 
ATOM   3209 C CA  . GLN B 2 188 ? 168.177 220.744 343.297 1.00 57.62  ? 188 GLN B CA  1 
ATOM   3210 C C   . GLN B 2 188 ? 169.422 221.528 343.672 1.00 57.63  ? 188 GLN B C   1 
ATOM   3211 O O   . GLN B 2 188 ? 169.673 221.763 344.857 1.00 61.58  ? 188 GLN B O   1 
ATOM   3212 C CB  . GLN B 2 188 ? 166.920 221.434 343.831 1.00 58.48  ? 188 GLN B CB  1 
ATOM   3213 C CG  . GLN B 2 188 ? 166.853 222.925 343.588 1.00 57.13  ? 188 GLN B CG  1 
ATOM   3214 C CD  . GLN B 2 188 ? 165.578 223.522 344.126 1.00 62.61  ? 188 GLN B CD  1 
ATOM   3215 O OE1 . GLN B 2 188 ? 164.523 222.892 344.087 1.00 57.72  ? 188 GLN B OE1 1 
ATOM   3216 N NE2 . GLN B 2 188 ? 165.667 224.736 344.648 1.00 69.53  ? 188 GLN B NE2 1 
ATOM   3217 N N   . GLY B 2 189 ? 170.191 221.935 342.671 1.00 46.84  ? 189 GLY B N   1 
ATOM   3218 C CA  . GLY B 2 189 ? 171.384 222.719 342.925 1.00 45.68  ? 189 GLY B CA  1 
ATOM   3219 C C   . GLY B 2 189 ? 172.121 222.982 341.633 1.00 50.78  ? 189 GLY B C   1 
ATOM   3220 O O   . GLY B 2 189 ? 171.705 222.553 340.552 1.00 59.21  ? 189 GLY B O   1 
ATOM   3221 N N   . ALA B 2 190 ? 173.230 223.706 341.759 1.00 36.59  ? 190 ALA B N   1 
ATOM   3222 C CA  . ALA B 2 190 ? 174.068 224.012 340.608 1.00 34.98  ? 190 ALA B CA  1 
ATOM   3223 C C   . ALA B 2 190 ? 175.428 224.526 341.052 1.00 44.44  ? 190 ALA B C   1 
ATOM   3224 O O   . ALA B 2 190 ? 175.511 225.466 341.845 1.00 55.48  ? 190 ALA B O   1 
ATOM   3225 C CB  . ALA B 2 190 ? 173.385 225.041 339.707 1.00 37.51  ? 190 ALA B CB  1 
ATOM   3226 N N   . LEU B 2 191 ? 176.495 223.915 340.553 1.00 48.32  ? 191 LEU B N   1 
ATOM   3227 C CA  . LEU B 2 191 ? 177.856 224.357 340.818 1.00 37.83  ? 191 LEU B CA  1 
ATOM   3228 C C   . LEU B 2 191 ? 178.407 225.108 339.617 1.00 45.77  ? 191 LEU B C   1 
ATOM   3229 O O   . LEU B 2 191 ? 177.991 224.893 338.479 1.00 57.72  ? 191 LEU B O   1 
ATOM   3230 C CB  . LEU B 2 191 ? 178.770 223.171 341.125 1.00 39.42  ? 191 LEU B CB  1 
ATOM   3231 C CG  . LEU B 2 191 ? 178.421 222.311 342.331 1.00 50.96  ? 191 LEU B CG  1 
ATOM   3232 C CD1 . LEU B 2 191 ? 179.291 221.074 342.343 1.00 51.92  ? 191 LEU B CD1 1 
ATOM   3233 C CD2 . LEU B 2 191 ? 178.594 223.098 343.612 1.00 51.68  ? 191 LEU B CD2 1 
ATOM   3234 N N   . GLY B 2 192 ? 179.371 225.979 339.886 1.00 42.07  ? 192 GLY B N   1 
ATOM   3235 C CA  . GLY B 2 192 ? 180.132 226.626 338.842 1.00 39.69  ? 192 GLY B CA  1 
ATOM   3236 C C   . GLY B 2 192 ? 181.606 226.386 339.068 1.00 41.06  ? 192 GLY B C   1 
ATOM   3237 O O   . GLY B 2 192 ? 182.136 226.713 340.136 1.00 46.79  ? 192 GLY B O   1 
ATOM   3238 N N   . VAL B 2 193 ? 182.269 225.793 338.080 1.00 43.05  ? 193 VAL B N   1 
ATOM   3239 C CA  . VAL B 2 193 ? 183.688 225.476 338.142 1.00 43.38  ? 193 VAL B CA  1 
ATOM   3240 C C   . VAL B 2 193 ? 184.410 226.429 337.205 1.00 47.87  ? 193 VAL B C   1 
ATOM   3241 O O   . VAL B 2 193 ? 184.173 226.412 335.990 1.00 49.16  ? 193 VAL B O   1 
ATOM   3242 C CB  . VAL B 2 193 ? 183.956 224.016 337.752 1.00 44.23  ? 193 VAL B CB  1 
ATOM   3243 C CG1 . VAL B 2 193 ? 185.407 223.650 338.015 1.00 45.39  ? 193 VAL B CG1 1 
ATOM   3244 C CG2 . VAL B 2 193 ? 183.012 223.091 338.500 1.00 46.04  ? 193 VAL B CG2 1 
ATOM   3245 N N   . PHE B 2 194 ? 185.287 227.258 337.766 1.00 40.91  ? 194 PHE B N   1 
ATOM   3246 C CA  . PHE B 2 194 ? 186.052 228.238 337.009 1.00 37.81  ? 194 PHE B CA  1 
ATOM   3247 C C   . PHE B 2 194 ? 187.532 227.913 337.131 1.00 45.04  ? 194 PHE B C   1 
ATOM   3248 O O   . PHE B 2 194 ? 188.030 227.679 338.236 1.00 51.39  ? 194 PHE B O   1 
ATOM   3249 C CB  . PHE B 2 194 ? 185.792 229.657 337.517 1.00 45.02  ? 194 PHE B CB  1 
ATOM   3250 C CG  . PHE B 2 194 ? 184.349 229.948 337.794 1.00 47.63  ? 194 PHE B CG  1 
ATOM   3251 C CD1 . PHE B 2 194 ? 183.496 230.319 336.773 1.00 46.29  ? 194 PHE B CD1 1 
ATOM   3252 C CD2 . PHE B 2 194 ? 183.848 229.862 339.079 1.00 47.80  ? 194 PHE B CD2 1 
ATOM   3253 C CE1 . PHE B 2 194 ? 182.170 230.589 337.027 1.00 43.57  ? 194 PHE B CE1 1 
ATOM   3254 C CE2 . PHE B 2 194 ? 182.523 230.132 339.339 1.00 50.99  ? 194 PHE B CE2 1 
ATOM   3255 C CZ  . PHE B 2 194 ? 181.683 230.497 338.311 1.00 44.77  ? 194 PHE B CZ  1 
ATOM   3256 N N   . ALA B 2 195 ? 188.235 227.909 336.000 1.00 40.30  ? 195 ALA B N   1 
ATOM   3257 C CA  . ALA B 2 195 ? 189.677 227.684 335.982 1.00 40.04  ? 195 ALA B CA  1 
ATOM   3258 C C   . ALA B 2 195 ? 190.363 229.044 335.912 1.00 34.76  ? 195 ALA B C   1 
ATOM   3259 O O   . ALA B 2 195 ? 190.731 229.539 334.848 1.00 37.09  ? 195 ALA B O   1 
ATOM   3260 C CB  . ALA B 2 195 ? 190.064 226.786 334.815 1.00 37.23  ? 195 ALA B CB  1 
ATOM   3261 N N   . VAL B 2 196 ? 190.541 229.650 337.081 1.00 28.11  ? 196 VAL B N   1 
ATOM   3262 C CA  . VAL B 2 196 ? 191.100 230.994 337.189 1.00 43.78  ? 196 VAL B CA  1 
ATOM   3263 C C   . VAL B 2 196 ? 192.594 230.949 336.884 1.00 46.15  ? 196 VAL B C   1 
ATOM   3264 O O   . VAL B 2 196 ? 193.338 230.253 337.588 1.00 42.17  ? 196 VAL B O   1 
ATOM   3265 C CB  . VAL B 2 196 ? 190.848 231.580 338.586 1.00 44.64  ? 196 VAL B CB  1 
ATOM   3266 C CG1 . VAL B 2 196 ? 191.410 232.986 338.683 1.00 44.92  ? 196 VAL B CG1 1 
ATOM   3267 C CG2 . VAL B 2 196 ? 189.364 231.568 338.904 1.00 42.58  ? 196 VAL B CG2 1 
ATOM   3268 N N   . PRO B 2 197 ? 193.085 231.667 335.873 1.00 41.02  ? 197 PRO B N   1 
ATOM   3269 C CA  . PRO B 2 197 ? 194.534 231.719 335.653 1.00 37.33  ? 197 PRO B CA  1 
ATOM   3270 C C   . PRO B 2 197 ? 195.187 232.728 336.580 1.00 48.79  ? 197 PRO B C   1 
ATOM   3271 O O   . PRO B 2 197 ? 194.628 233.789 336.867 1.00 55.87  ? 197 PRO B O   1 
ATOM   3272 C CB  . PRO B 2 197 ? 194.663 232.157 334.187 1.00 23.76  ? 197 PRO B CB  1 
ATOM   3273 C CG  . PRO B 2 197 ? 193.265 232.291 333.661 1.00 33.51  ? 197 PRO B CG  1 
ATOM   3274 C CD  . PRO B 2 197 ? 192.364 232.414 334.834 1.00 34.65  ? 197 PRO B CD  1 
ATOM   3275 N N   . GLU B 2 198 ? 196.387 232.393 337.046 1.00 49.29  ? 198 GLU B N   1 
ATOM   3276 C CA  . GLU B 2 198 ? 197.121 233.266 337.956 1.00 42.26  ? 198 GLU B CA  1 
ATOM   3277 C C   . GLU B 2 198 ? 196.261 233.626 339.160 1.00 52.68  ? 198 GLU B C   1 
ATOM   3278 O O   . GLU B 2 198 ? 196.268 234.761 339.637 1.00 53.44  ? 198 GLU B O   1 
ATOM   3279 C CB  . GLU B 2 198 ? 197.586 234.533 337.240 1.00 42.27  ? 198 GLU B CB  1 
ATOM   3280 C CG  . GLU B 2 198 ? 198.435 234.292 336.010 1.00 51.32  ? 198 GLU B CG  1 
ATOM   3281 C CD  . GLU B 2 198 ? 199.848 233.883 336.350 1.00 65.88  ? 198 GLU B CD  1 
ATOM   3282 O OE1 . GLU B 2 198 ? 200.139 233.688 337.549 1.00 67.64  ? 198 GLU B OE1 1 
ATOM   3283 O OE2 . GLU B 2 198 ? 200.670 233.762 335.419 1.00 65.99  ? 198 GLU B OE2 1 
ATOM   3284 N N   . MET B 2 199 ? 195.506 232.650 339.659 1.00 53.61  ? 199 MET B N   1 
ATOM   3285 C CA  . MET B 2 199 ? 194.511 232.943 340.681 1.00 54.25  ? 199 MET B CA  1 
ATOM   3286 C C   . MET B 2 199 ? 195.177 233.438 341.954 1.00 50.48  ? 199 MET B C   1 
ATOM   3287 O O   . MET B 2 199 ? 195.776 232.655 342.696 1.00 55.63  ? 199 MET B O   1 
ATOM   3288 C CB  . MET B 2 199 ? 193.661 231.711 340.994 1.00 56.41  ? 199 MET B CB  1 
ATOM   3289 C CG  . MET B 2 199 ? 192.494 232.002 341.933 1.00 56.25  ? 199 MET B CG  1 
ATOM   3290 S SD  . MET B 2 199 ? 191.973 230.577 342.903 1.00 64.24  ? 199 MET B SD  1 
ATOM   3291 C CE  . MET B 2 199 ? 191.165 229.596 341.650 1.00 50.09  ? 199 MET B CE  1 
ATOM   3292 N N   . CYS B 2 200 ? 195.068 234.733 342.214 1.00 51.83  ? 200 CYS B N   1 
ATOM   3293 C CA  . CYS B 2 200 ? 195.465 235.294 343.491 1.00 57.78  ? 200 CYS B CA  1 
ATOM   3294 C C   . CYS B 2 200 ? 194.258 235.353 344.417 1.00 61.04  ? 200 CYS B C   1 
ATOM   3295 O O   . CYS B 2 200 ? 193.108 235.268 343.984 1.00 62.40  ? 200 CYS B O   1 
ATOM   3296 C CB  . CYS B 2 200 ? 196.062 236.689 343.312 1.00 64.23  ? 200 CYS B CB  1 
ATOM   3297 S SG  . CYS B 2 200 ? 197.551 236.739 342.292 1.00 85.68  ? 200 CYS B SG  1 
ATOM   3298 N N   . LEU B 2 201 ? 194.533 235.493 345.709 1.00 60.62  ? 201 LEU B N   1 
ATOM   3299 C CA  . LEU B 2 201 ? 193.486 235.606 346.709 1.00 58.03  ? 201 LEU B CA  1 
ATOM   3300 C C   . LEU B 2 201 ? 193.895 236.654 347.730 1.00 57.61  ? 201 LEU B C   1 
ATOM   3301 O O   . LEU B 2 201 ? 195.083 236.861 347.987 1.00 65.08  ? 201 LEU B O   1 
ATOM   3302 C CB  . LEU B 2 201 ? 193.218 234.262 347.397 1.00 63.61  ? 201 LEU B CB  1 
ATOM   3303 C CG  . LEU B 2 201 ? 192.796 233.115 346.476 1.00 64.75  ? 201 LEU B CG  1 
ATOM   3304 C CD1 . LEU B 2 201 ? 192.801 231.806 347.231 1.00 65.34  ? 201 LEU B CD1 1 
ATOM   3305 C CD2 . LEU B 2 201 ? 191.425 233.363 345.880 1.00 63.31  ? 201 LEU B CD2 1 
ATOM   3306 N N   . ALA B 2 202 ? 192.899 237.312 348.308 1.00 50.17  ? 202 ALA B N   1 
ATOM   3307 C CA  . ALA B 2 202 ? 193.154 238.388 349.251 1.00 57.51  ? 202 ALA B CA  1 
ATOM   3308 C C   . ALA B 2 202 ? 193.601 237.837 350.598 1.00 63.10  ? 202 ALA B C   1 
ATOM   3309 O O   . ALA B 2 202 ? 193.200 236.747 351.014 1.00 62.95  ? 202 ALA B O   1 
ATOM   3310 C CB  . ALA B 2 202 ? 191.903 239.242 349.436 1.00 65.71  ? 202 ALA B CB  1 
ATOM   3311 N N   . GLY B 2 203 ? 194.438 238.611 351.282 1.00 77.90  ? 203 GLY B N   1 
ATOM   3312 C CA  . GLY B 2 203 ? 194.902 238.247 352.600 1.00 75.67  ? 203 GLY B CA  1 
ATOM   3313 C C   . GLY B 2 203 ? 193.852 238.499 353.662 1.00 75.64  ? 203 GLY B C   1 
ATOM   3314 O O   . GLY B 2 203 ? 192.766 239.017 353.405 1.00 74.28  ? 203 GLY B O   1 
ATOM   3315 N N   . ASP B 2 204 ? 194.195 238.118 354.890 1.00 85.57  ? 204 ASP B N   1 
ATOM   3316 C CA  . ASP B 2 204 ? 193.289 238.241 356.022 1.00 87.26  ? 204 ASP B CA  1 
ATOM   3317 C C   . ASP B 2 204 ? 193.577 239.452 356.896 1.00 88.96  ? 204 ASP B C   1 
ATOM   3318 O O   . ASP B 2 204 ? 192.745 239.795 357.740 1.00 93.55  ? 204 ASP B O   1 
ATOM   3319 C CB  . ASP B 2 204 ? 193.356 236.982 356.892 1.00 91.12  ? 204 ASP B CB  1 
ATOM   3320 C CG  . ASP B 2 204 ? 194.741 236.744 357.461 1.00 93.47  ? 204 ASP B CG  1 
ATOM   3321 O OD1 . ASP B 2 204 ? 195.672 237.489 357.091 1.00 89.69  ? 204 ASP B OD1 1 
ATOM   3322 O OD2 . ASP B 2 204 ? 194.899 235.816 358.280 1.00 93.02  ? 204 ASP B OD2 1 
ATOM   3323 N N   . SER B 2 205 ? 194.724 240.101 356.724 1.00 87.16  ? 205 SER B N   1 
ATOM   3324 C CA  . SER B 2 205 ? 195.130 241.220 357.562 1.00 91.71  ? 205 SER B CA  1 
ATOM   3325 C C   . SER B 2 205 ? 194.975 242.520 356.789 1.00 90.29  ? 205 SER B C   1 
ATOM   3326 O O   . SER B 2 205 ? 195.472 242.642 355.664 1.00 89.65  ? 205 SER B O   1 
ATOM   3327 C CB  . SER B 2 205 ? 196.577 241.055 358.029 1.00 89.83  ? 205 SER B CB  1 
ATOM   3328 O OG  . SER B 2 205 ? 196.968 242.134 358.859 1.00 84.93  ? 205 SER B OG  1 
ATOM   3329 N N   . ASN B 2 206 ? 194.285 243.486 357.393 1.00 94.11  ? 206 ASN B N   1 
ATOM   3330 C CA  . ASN B 2 206 ? 194.177 244.818 356.815 1.00 94.25  ? 206 ASN B CA  1 
ATOM   3331 C C   . ASN B 2 206 ? 195.362 245.704 357.168 1.00 95.47  ? 206 ASN B C   1 
ATOM   3332 O O   . ASN B 2 206 ? 195.483 246.799 356.609 1.00 95.84  ? 206 ASN B O   1 
ATOM   3333 C CB  . ASN B 2 206 ? 192.885 245.490 357.280 1.00 94.69  ? 206 ASN B CB  1 
ATOM   3334 C CG  . ASN B 2 206 ? 191.654 244.677 356.944 1.00 97.01  ? 206 ASN B CG  1 
ATOM   3335 O OD1 . ASN B 2 206 ? 190.861 244.339 357.821 1.00 96.12  ? 206 ASN B OD1 1 
ATOM   3336 N ND2 . ASN B 2 206 ? 191.489 244.355 355.667 1.00 96.95  ? 206 ASN B ND2 1 
ATOM   3337 N N   . THR B 2 207 ? 196.229 245.264 358.078 1.00 96.97  ? 207 THR B N   1 
ATOM   3338 C CA  . THR B 2 207 ? 197.412 246.021 358.455 1.00 97.07  ? 207 THR B CA  1 
ATOM   3339 C C   . THR B 2 207 ? 198.620 245.704 357.584 1.00 97.94  ? 207 THR B C   1 
ATOM   3340 O O   . THR B 2 207 ? 199.639 246.395 357.690 1.00 99.07  ? 207 THR B O   1 
ATOM   3341 C CB  . THR B 2 207 ? 197.759 245.750 359.924 1.00 96.82  ? 207 THR B CB  1 
ATOM   3342 O OG1 . THR B 2 207 ? 196.579 245.882 360.726 1.00 98.52  ? 207 THR B OG1 1 
ATOM   3343 C CG2 . THR B 2 207 ? 198.812 246.727 360.421 1.00 94.92  ? 207 THR B CG2 1 
ATOM   3344 N N   . THR B 2 208 ? 198.532 244.691 356.725 1.00 88.63  ? 208 THR B N   1 
ATOM   3345 C CA  . THR B 2 208 ? 199.645 244.314 355.867 1.00 87.16  ? 208 THR B CA  1 
ATOM   3346 C C   . THR B 2 208 ? 199.092 243.785 354.553 1.00 86.16  ? 208 THR B C   1 
ATOM   3347 O O   . THR B 2 208 ? 197.934 243.371 354.465 1.00 89.07  ? 208 THR B O   1 
ATOM   3348 C CB  . THR B 2 208 ? 200.538 243.260 356.533 1.00 86.90  ? 208 THR B CB  1 
ATOM   3349 O OG1 . THR B 2 208 ? 200.762 243.616 357.903 1.00 87.72  ? 208 THR B OG1 1 
ATOM   3350 C CG2 . THR B 2 208 ? 201.877 243.164 355.818 1.00 84.55  ? 208 THR B CG2 1 
ATOM   3351 N N   . THR B 2 209 ? 199.939 243.803 353.526 1.00 81.31  ? 209 THR B N   1 
ATOM   3352 C CA  . THR B 2 209 ? 199.565 243.357 352.193 1.00 81.98  ? 209 THR B CA  1 
ATOM   3353 C C   . THR B 2 209 ? 200.559 242.316 351.702 1.00 80.26  ? 209 THR B C   1 
ATOM   3354 O O   . THR B 2 209 ? 201.755 242.401 351.995 1.00 81.17  ? 209 THR B O   1 
ATOM   3355 C CB  . THR B 2 209 ? 199.518 244.528 351.207 1.00 82.98  ? 209 THR B CB  1 
ATOM   3356 O OG1 . THR B 2 209 ? 200.794 245.180 351.175 1.00 84.31  ? 209 THR B OG1 1 
ATOM   3357 C CG2 . THR B 2 209 ? 198.450 245.528 351.617 1.00 82.10  ? 209 THR B CG2 1 
ATOM   3358 N N   . MET B 2 210 ? 200.056 241.336 350.953 1.00 70.12  ? 210 MET B N   1 
ATOM   3359 C CA  . MET B 2 210 ? 200.893 240.281 350.384 1.00 70.07  ? 210 MET B CA  1 
ATOM   3360 C C   . MET B 2 210 ? 201.672 239.553 351.474 1.00 69.43  ? 210 MET B C   1 
ATOM   3361 O O   . MET B 2 210 ? 202.827 239.168 351.287 1.00 70.18  ? 210 MET B O   1 
ATOM   3362 C CB  . MET B 2 210 ? 201.847 240.849 349.331 1.00 72.19  ? 210 MET B CB  1 
ATOM   3363 C CG  . MET B 2 210 ? 201.154 241.500 348.148 1.00 73.78  ? 210 MET B CG  1 
ATOM   3364 S SD  . MET B 2 210 ? 202.310 242.028 346.871 1.00 70.81  ? 210 MET B SD  1 
ATOM   3365 C CE  . MET B 2 210 ? 203.333 243.171 347.791 1.00 70.65  ? 210 MET B CE  1 
ATOM   3366 N N   . HIS B 2 211 ? 201.034 239.357 352.624 1.00 72.31  ? 211 HIS B N   1 
ATOM   3367 C CA  . HIS B 2 211 ? 201.694 238.795 353.792 1.00 75.22  ? 211 HIS B CA  1 
ATOM   3368 C C   . HIS B 2 211 ? 201.432 237.306 353.975 1.00 77.11  ? 211 HIS B C   1 
ATOM   3369 O O   . HIS B 2 211 ? 201.915 236.725 354.951 1.00 78.54  ? 211 HIS B O   1 
ATOM   3370 C CB  . HIS B 2 211 ? 201.254 239.549 355.048 1.00 77.28  ? 211 HIS B CB  1 
ATOM   3371 C CG  . HIS B 2 211 ? 202.198 239.403 356.199 1.00 80.43  ? 211 HIS B CG  1 
ATOM   3372 N ND1 . HIS B 2 211 ? 203.557 239.586 356.071 1.00 78.91  ? 211 HIS B ND1 1 
ATOM   3373 C CD2 . HIS B 2 211 ? 201.979 239.097 357.499 1.00 80.66  ? 211 HIS B CD2 1 
ATOM   3374 C CE1 . HIS B 2 211 ? 204.137 239.396 357.243 1.00 80.33  ? 211 HIS B CE1 1 
ATOM   3375 N NE2 . HIS B 2 211 ? 203.201 239.098 358.126 1.00 82.19  ? 211 HIS B NE2 1 
ATOM   3376 N N   . THR B 2 212 ? 200.688 236.676 353.071 1.00 70.52  ? 212 THR B N   1 
ATOM   3377 C CA  . THR B 2 212 ? 200.376 235.262 353.227 1.00 64.03  ? 212 THR B CA  1 
ATOM   3378 C C   . THR B 2 212 ? 201.647 234.425 353.143 1.00 68.44  ? 212 THR B C   1 
ATOM   3379 O O   . THR B 2 212 ? 202.600 234.767 352.440 1.00 69.33  ? 212 THR B O   1 
ATOM   3380 C CB  . THR B 2 212 ? 199.381 234.815 352.159 1.00 60.18  ? 212 THR B CB  1 
ATOM   3381 O OG1 . THR B 2 212 ? 198.220 235.653 352.207 1.00 65.88  ? 212 THR B OG1 1 
ATOM   3382 C CG2 . THR B 2 212 ? 198.965 233.373 352.385 1.00 64.31  ? 212 THR B CG2 1 
ATOM   3383 N N   . SER B 2 213 ? 201.653 233.316 353.875 1.00 70.09  ? 213 SER B N   1 
ATOM   3384 C CA  . SER B 2 213 ? 202.805 232.432 353.930 1.00 70.29  ? 213 SER B CA  1 
ATOM   3385 C C   . SER B 2 213 ? 202.697 231.338 352.874 1.00 71.91  ? 213 SER B C   1 
ATOM   3386 O O   . SER B 2 213 ? 201.622 231.052 352.343 1.00 74.06  ? 213 SER B O   1 
ATOM   3387 C CB  . SER B 2 213 ? 202.933 231.803 355.317 1.00 70.35  ? 213 SER B CB  1 
ATOM   3388 O OG  . SER B 2 213 ? 201.796 231.018 355.623 1.00 74.09  ? 213 SER B OG  1 
ATOM   3389 N N   . TYR B 2 214 ? 203.841 230.722 352.573 1.00 63.47  ? 214 TYR B N   1 
ATOM   3390 C CA  . TYR B 2 214 ? 203.864 229.645 351.589 1.00 61.97  ? 214 TYR B CA  1 
ATOM   3391 C C   . TYR B 2 214 ? 203.021 228.465 352.049 1.00 60.79  ? 214 TYR B C   1 
ATOM   3392 O O   . TYR B 2 214 ? 202.306 227.851 351.249 1.00 65.12  ? 214 TYR B O   1 
ATOM   3393 C CB  . TYR B 2 214 ? 205.304 229.203 351.335 1.00 60.51  ? 214 TYR B CB  1 
ATOM   3394 C CG  . TYR B 2 214 ? 205.446 228.146 350.266 1.00 57.85  ? 214 TYR B CG  1 
ATOM   3395 C CD1 . TYR B 2 214 ? 205.371 226.798 350.580 1.00 57.31  ? 214 TYR B CD1 1 
ATOM   3396 C CD2 . TYR B 2 214 ? 205.662 228.497 348.942 1.00 61.49  ? 214 TYR B CD2 1 
ATOM   3397 C CE1 . TYR B 2 214 ? 205.501 225.832 349.607 1.00 56.44  ? 214 TYR B CE1 1 
ATOM   3398 C CE2 . TYR B 2 214 ? 205.794 227.536 347.962 1.00 57.15  ? 214 TYR B CE2 1 
ATOM   3399 C CZ  . TYR B 2 214 ? 205.713 226.206 348.300 1.00 55.69  ? 214 TYR B CZ  1 
ATOM   3400 O OH  . TYR B 2 214 ? 205.843 225.245 347.326 1.00 61.15  ? 214 TYR B OH  1 
ATOM   3401 N N   . GLN B 2 215 ? 203.091 228.132 353.338 1.00 65.24  ? 215 GLN B N   1 
ATOM   3402 C CA  . GLN B 2 215 ? 202.381 226.961 353.839 1.00 69.27  ? 215 GLN B CA  1 
ATOM   3403 C C   . GLN B 2 215 ? 200.874 227.131 353.705 1.00 73.68  ? 215 GLN B C   1 
ATOM   3404 O O   . GLN B 2 215 ? 200.165 226.188 353.337 1.00 72.25  ? 215 GLN B O   1 
ATOM   3405 C CB  . GLN B 2 215 ? 202.761 226.703 355.296 1.00 70.33  ? 215 GLN B CB  1 
ATOM   3406 C CG  . GLN B 2 215 ? 204.254 226.525 355.533 1.00 74.09  ? 215 GLN B CG  1 
ATOM   3407 C CD  . GLN B 2 215 ? 204.991 227.842 355.680 1.00 75.09  ? 215 GLN B CD  1 
ATOM   3408 O OE1 . GLN B 2 215 ? 204.410 228.850 356.081 1.00 70.73  ? 215 GLN B OE1 1 
ATOM   3409 N NE2 . GLN B 2 215 ? 206.276 227.842 355.348 1.00 75.45  ? 215 GLN B NE2 1 
ATOM   3410 N N   . ASN B 2 216 ? 200.365 228.328 354.001 1.00 71.88  ? 216 ASN B N   1 
ATOM   3411 C CA  . ASN B 2 216 ? 198.925 228.551 353.991 1.00 67.43  ? 216 ASN B CA  1 
ATOM   3412 C C   . ASN B 2 216 ? 198.390 228.817 352.590 1.00 62.54  ? 216 ASN B C   1 
ATOM   3413 O O   . ASN B 2 216 ? 197.220 228.533 352.317 1.00 65.55  ? 216 ASN B O   1 
ATOM   3414 C CB  . ASN B 2 216 ? 198.577 229.720 354.909 1.00 65.56  ? 216 ASN B CB  1 
ATOM   3415 C CG  . ASN B 2 216 ? 199.241 229.609 356.263 1.00 70.11  ? 216 ASN B CG  1 
ATOM   3416 O OD1 . ASN B 2 216 ? 200.114 230.405 356.605 1.00 75.21  ? 216 ASN B OD1 1 
ATOM   3417 N ND2 . ASN B 2 216 ? 198.833 228.616 357.043 1.00 69.57  ? 216 ASN B ND2 1 
ATOM   3418 N N   . ALA B 2 217 ? 199.216 229.359 351.699 1.00 51.80  ? 217 ALA B N   1 
ATOM   3419 C CA  . ALA B 2 217 ? 198.789 229.651 350.337 1.00 52.52  ? 217 ALA B CA  1 
ATOM   3420 C C   . ALA B 2 217 ? 198.860 228.438 349.422 1.00 58.84  ? 217 ALA B C   1 
ATOM   3421 O O   . ALA B 2 217 ? 198.441 228.534 348.264 1.00 59.89  ? 217 ALA B O   1 
ATOM   3422 C CB  . ALA B 2 217 ? 199.639 230.779 349.752 1.00 56.90  ? 217 ALA B CB  1 
ATOM   3423 N N   . ASN B 2 218 ? 199.382 227.314 349.903 1.00 62.92  ? 218 ASN B N   1 
ATOM   3424 C CA  . ASN B 2 218 ? 199.502 226.084 349.122 1.00 57.53  ? 218 ASN B CA  1 
ATOM   3425 C C   . ASN B 2 218 ? 198.959 224.927 349.951 1.00 62.76  ? 218 ASN B C   1 
ATOM   3426 O O   . ASN B 2 218 ? 199.719 224.099 350.465 1.00 57.77  ? 218 ASN B O   1 
ATOM   3427 C CB  . ASN B 2 218 ? 200.954 225.842 348.712 1.00 57.86  ? 218 ASN B CB  1 
ATOM   3428 C CG  . ASN B 2 218 ? 201.420 226.799 347.636 1.00 59.58  ? 218 ASN B CG  1 
ATOM   3429 O OD1 . ASN B 2 218 ? 201.588 226.417 346.479 1.00 63.28  ? 218 ASN B OD1 1 
ATOM   3430 N ND2 . ASN B 2 218 ? 201.619 228.055 348.009 1.00 59.70  ? 218 ASN B ND2 1 
ATOM   3431 N N   . PRO B 2 219 ? 197.636 224.847 350.106 1.00 62.99  ? 219 PRO B N   1 
ATOM   3432 C CA  . PRO B 2 219 ? 197.067 223.787 350.954 1.00 59.07  ? 219 PRO B CA  1 
ATOM   3433 C C   . PRO B 2 219 ? 197.383 222.384 350.469 1.00 59.81  ? 219 PRO B C   1 
ATOM   3434 O O   . PRO B 2 219 ? 197.406 221.452 351.281 1.00 57.52  ? 219 PRO B O   1 
ATOM   3435 C CB  . PRO B 2 219 ? 195.560 224.076 350.910 1.00 62.05  ? 219 PRO B CB  1 
ATOM   3436 C CG  . PRO B 2 219 ? 195.354 224.853 349.656 1.00 60.41  ? 219 PRO B CG  1 
ATOM   3437 C CD  . PRO B 2 219 ? 196.593 225.673 349.477 1.00 58.48  ? 219 PRO B CD  1 
ATOM   3438 N N   . GLY B 2 220 ? 197.616 222.203 349.177 1.00 62.64  ? 220 GLY B N   1 
ATOM   3439 C CA  . GLY B 2 220 ? 197.897 220.889 348.625 1.00 56.09  ? 220 GLY B CA  1 
ATOM   3440 C C   . GLY B 2 220 ? 196.672 220.311 347.931 1.00 61.34  ? 220 GLY B C   1 
ATOM   3441 O O   . GLY B 2 220 ? 195.999 221.004 347.171 1.00 64.59  ? 220 GLY B O   1 
ATOM   3442 N N   . GLU B 2 221 ? 196.392 219.033 348.192 1.00 66.64  ? 221 GLU B N   1 
ATOM   3443 C CA  . GLU B 2 221 ? 195.178 218.414 347.676 1.00 63.57  ? 221 GLU B CA  1 
ATOM   3444 C C   . GLU B 2 221 ? 193.968 218.698 348.551 1.00 63.12  ? 221 GLU B C   1 
ATOM   3445 O O   . GLU B 2 221 ? 192.837 218.629 348.061 1.00 64.11  ? 221 GLU B O   1 
ATOM   3446 C CB  . GLU B 2 221 ? 195.362 216.901 347.550 1.00 65.66  ? 221 GLU B CB  1 
ATOM   3447 C CG  . GLU B 2 221 ? 195.636 216.197 348.866 1.00 68.86  ? 221 GLU B CG  1 
ATOM   3448 C CD  . GLU B 2 221 ? 195.552 214.692 348.747 1.00 70.61  ? 221 GLU B CD  1 
ATOM   3449 O OE1 . GLU B 2 221 ? 195.277 214.198 347.635 1.00 70.68  ? 221 GLU B OE1 1 
ATOM   3450 O OE2 . GLU B 2 221 ? 195.757 214.001 349.767 1.00 68.35  ? 221 GLU B OE2 1 
ATOM   3451 N N   . LYS B 2 222 ? 194.179 219.007 349.831 1.00 65.34  ? 222 LYS B N   1 
ATOM   3452 C CA  . LYS B 2 222 ? 193.060 219.339 350.704 1.00 67.20  ? 222 LYS B CA  1 
ATOM   3453 C C   . LYS B 2 222 ? 192.278 220.529 350.170 1.00 65.30  ? 222 LYS B C   1 
ATOM   3454 O O   . LYS B 2 222 ? 191.064 220.620 350.381 1.00 61.66  ? 222 LYS B O   1 
ATOM   3455 C CB  . LYS B 2 222 ? 193.570 219.629 352.116 1.00 67.52  ? 222 LYS B CB  1 
ATOM   3456 C CG  . LYS B 2 222 ? 192.486 220.035 353.107 1.00 64.59  ? 222 LYS B CG  1 
ATOM   3457 C CD  . LYS B 2 222 ? 193.063 220.344 354.482 1.00 65.32  ? 222 LYS B CD  1 
ATOM   3458 C CE  . LYS B 2 222 ? 193.978 221.560 354.451 1.00 67.51  ? 222 LYS B CE  1 
ATOM   3459 N NZ  . LYS B 2 222 ? 194.405 221.977 355.814 1.00 69.36  ? 222 LYS B NZ  1 
ATOM   3460 N N   . GLY B 2 223 ? 192.948 221.444 349.484 1.00 59.79  ? 223 GLY B N   1 
ATOM   3461 C CA  . GLY B 2 223 ? 192.284 222.599 348.930 1.00 57.92  ? 223 GLY B CA  1 
ATOM   3462 C C   . GLY B 2 223 ? 191.990 223.652 349.978 1.00 57.71  ? 223 GLY B C   1 
ATOM   3463 O O   . GLY B 2 223 ? 192.402 223.572 351.138 1.00 55.79  ? 223 GLY B O   1 
ATOM   3464 N N   . GLY B 2 224 ? 191.251 224.670 349.539 1.00 56.44  ? 224 GLY B N   1 
ATOM   3465 C CA  . GLY B 2 224 ? 190.805 225.732 350.413 1.00 56.99  ? 224 GLY B CA  1 
ATOM   3466 C C   . GLY B 2 224 ? 189.302 225.911 350.315 1.00 59.12  ? 224 GLY B C   1 
ATOM   3467 O O   . GLY B 2 224 ? 188.615 225.189 349.590 1.00 67.55  ? 224 GLY B O   1 
ATOM   3468 N N   . THR B 2 225 ? 188.810 226.891 351.066 1.00 51.72  ? 225 THR B N   1 
ATOM   3469 C CA  . THR B 2 225 ? 187.386 227.176 351.118 1.00 52.93  ? 225 THR B CA  1 
ATOM   3470 C C   . THR B 2 225 ? 187.169 228.679 351.062 1.00 56.66  ? 225 THR B C   1 
ATOM   3471 O O   . THR B 2 225 ? 188.026 229.462 351.477 1.00 57.42  ? 225 THR B O   1 
ATOM   3472 C CB  . THR B 2 225 ? 186.747 226.609 352.390 1.00 55.37  ? 225 THR B CB  1 
ATOM   3473 O OG1 . THR B 2 225 ? 187.381 227.179 353.541 1.00 58.41  ? 225 THR B OG1 1 
ATOM   3474 C CG2 . THR B 2 225 ? 186.895 225.101 352.434 1.00 51.54  ? 225 THR B CG2 1 
ATOM   3475 N N   . PHE B 2 226 ? 186.011 229.071 350.540 1.00 55.11  ? 226 PHE B N   1 
ATOM   3476 C CA  . PHE B 2 226 ? 185.596 230.464 350.539 1.00 49.88  ? 226 PHE B CA  1 
ATOM   3477 C C   . PHE B 2 226 ? 184.758 230.745 351.776 1.00 54.45  ? 226 PHE B C   1 
ATOM   3478 O O   . PHE B 2 226 ? 183.893 229.948 352.148 1.00 57.46  ? 226 PHE B O   1 
ATOM   3479 C CB  . PHE B 2 226 ? 184.792 230.793 349.282 1.00 52.03  ? 226 PHE B CB  1 
ATOM   3480 C CG  . PHE B 2 226 ? 185.616 230.845 348.030 1.00 47.64  ? 226 PHE B CG  1 
ATOM   3481 C CD1 . PHE B 2 226 ? 185.850 229.702 347.292 1.00 50.34  ? 226 PHE B CD1 1 
ATOM   3482 C CD2 . PHE B 2 226 ? 186.147 232.040 347.588 1.00 51.53  ? 226 PHE B CD2 1 
ATOM   3483 C CE1 . PHE B 2 226 ? 186.603 229.751 346.140 1.00 49.20  ? 226 PHE B CE1 1 
ATOM   3484 C CE2 . PHE B 2 226 ? 186.900 232.092 346.437 1.00 54.11  ? 226 PHE B CE2 1 
ATOM   3485 C CZ  . PHE B 2 226 ? 187.126 230.947 345.712 1.00 50.84  ? 226 PHE B CZ  1 
ATOM   3486 N N   . THR B 2 227 ? 185.019 231.880 352.413 1.00 67.87  ? 227 THR B N   1 
ATOM   3487 C CA  . THR B 2 227 ? 184.305 232.278 353.616 1.00 70.64  ? 227 THR B CA  1 
ATOM   3488 C C   . THR B 2 227 ? 183.170 233.224 353.252 1.00 71.26  ? 227 THR B C   1 
ATOM   3489 O O   . THR B 2 227 ? 183.308 234.063 352.357 1.00 69.86  ? 227 THR B O   1 
ATOM   3490 C CB  . THR B 2 227 ? 185.245 232.949 354.621 1.00 73.19  ? 227 THR B CB  1 
ATOM   3491 O OG1 . THR B 2 227 ? 184.522 233.269 355.816 1.00 70.91  ? 227 THR B OG1 1 
ATOM   3492 C CG2 . THR B 2 227 ? 185.852 234.221 354.041 1.00 73.60  ? 227 THR B CG2 1 
ATOM   3493 N N   . GLY B 2 228 ? 182.045 233.080 353.950 1.00 74.47  ? 228 GLY B N   1 
ATOM   3494 C CA  . GLY B 2 228 ? 180.889 233.904 353.642 1.00 74.20  ? 228 GLY B CA  1 
ATOM   3495 C C   . GLY B 2 228 ? 181.143 235.381 353.868 1.00 77.51  ? 228 GLY B C   1 
ATOM   3496 O O   . GLY B 2 228 ? 180.749 236.220 353.054 1.00 74.65  ? 228 GLY B O   1 
ATOM   3497 N N   . THR B 2 229 ? 181.805 235.720 354.972 1.00 78.31  ? 229 THR B N   1 
ATOM   3498 C CA  . THR B 2 229 ? 182.040 237.106 355.351 1.00 76.06  ? 229 THR B CA  1 
ATOM   3499 C C   . THR B 2 229 ? 183.504 237.305 355.707 1.00 74.79  ? 229 THR B C   1 
ATOM   3500 O O   . THR B 2 229 ? 184.137 236.422 356.292 1.00 74.28  ? 229 THR B O   1 
ATOM   3501 C CB  . THR B 2 229 ? 181.162 237.511 356.539 1.00 77.06  ? 229 THR B CB  1 
ATOM   3502 O OG1 . THR B 2 229 ? 179.794 237.194 356.255 1.00 77.42  ? 229 THR B OG1 1 
ATOM   3503 C CG2 . THR B 2 229 ? 181.286 239.003 356.812 1.00 74.35  ? 229 THR B CG2 1 
ATOM   3504 N N   . PHE B 2 230 ? 184.033 238.472 355.353 1.00 85.98  ? 230 PHE B N   1 
ATOM   3505 C CA  . PHE B 2 230 ? 185.411 238.806 355.679 1.00 85.22  ? 230 PHE B CA  1 
ATOM   3506 C C   . PHE B 2 230 ? 185.579 238.972 357.184 1.00 86.03  ? 230 PHE B C   1 
ATOM   3507 O O   . PHE B 2 230 ? 184.683 239.448 357.886 1.00 85.94  ? 230 PHE B O   1 
ATOM   3508 C CB  . PHE B 2 230 ? 185.826 240.092 354.963 1.00 85.96  ? 230 PHE B CB  1 
ATOM   3509 C CG  . PHE B 2 230 ? 187.279 240.438 355.126 1.00 84.64  ? 230 PHE B CG  1 
ATOM   3510 C CD1 . PHE B 2 230 ? 187.720 241.144 356.231 1.00 85.36  ? 230 PHE B CD1 1 
ATOM   3511 C CD2 . PHE B 2 230 ? 188.202 240.067 354.165 1.00 85.16  ? 230 PHE B CD2 1 
ATOM   3512 C CE1 . PHE B 2 230 ? 189.054 241.463 356.377 1.00 85.51  ? 230 PHE B CE1 1 
ATOM   3513 C CE2 . PHE B 2 230 ? 189.536 240.386 354.307 1.00 84.55  ? 230 PHE B CE2 1 
ATOM   3514 C CZ  . PHE B 2 230 ? 189.962 241.085 355.414 1.00 84.20  ? 230 PHE B CZ  1 
ATOM   3515 N N   . THR B 2 231 ? 186.746 238.570 357.678 1.00 90.83  ? 231 THR B N   1 
ATOM   3516 C CA  . THR B 2 231 ? 187.071 238.710 359.091 1.00 93.73  ? 231 THR B CA  1 
ATOM   3517 C C   . THR B 2 231 ? 188.554 239.032 359.236 1.00 95.25  ? 231 THR B C   1 
ATOM   3518 O O   . THR B 2 231 ? 189.399 238.159 359.003 1.00 92.30  ? 231 THR B O   1 
ATOM   3519 C CB  . THR B 2 231 ? 186.723 237.433 359.857 1.00 93.01  ? 231 THR B CB  1 
ATOM   3520 O OG1 . THR B 2 231 ? 185.360 237.075 359.601 1.00 93.04  ? 231 THR B OG1 1 
ATOM   3521 C CG2 . THR B 2 231 ? 186.914 237.640 361.354 1.00 92.68  ? 231 THR B CG2 1 
ATOM   3522 N N   . PRO B 2 232 ? 188.916 240.261 359.610 1.00 98.31  ? 232 PRO B N   1 
ATOM   3523 C CA  . PRO B 2 232 ? 190.339 240.603 359.705 1.00 98.36  ? 232 PRO B CA  1 
ATOM   3524 C C   . PRO B 2 232 ? 191.061 239.735 360.724 1.00 98.09  ? 232 PRO B C   1 
ATOM   3525 O O   . PRO B 2 232 ? 190.502 239.341 361.749 1.00 96.74  ? 232 PRO B O   1 
ATOM   3526 C CB  . PRO B 2 232 ? 190.328 242.075 360.136 1.00 97.27  ? 232 PRO B CB  1 
ATOM   3527 C CG  . PRO B 2 232 ? 188.976 242.578 359.789 1.00 97.26  ? 232 PRO B CG  1 
ATOM   3528 C CD  . PRO B 2 232 ? 188.053 241.413 359.924 1.00 95.73  ? 232 PRO B CD  1 
ATOM   3529 N N   . ASP B 2 233 ? 192.326 239.438 360.425 1.00 98.04  ? 233 ASP B N   1 
ATOM   3530 C CA  . ASP B 2 233 ? 193.194 238.704 361.345 1.00 97.19  ? 233 ASP B CA  1 
ATOM   3531 C C   . ASP B 2 233 ? 193.764 239.707 362.344 1.00 97.05  ? 233 ASP B C   1 
ATOM   3532 O O   . ASP B 2 233 ? 194.892 240.192 362.225 1.00 97.64  ? 233 ASP B O   1 
ATOM   3533 C CB  . ASP B 2 233 ? 194.290 237.972 360.581 1.00 98.92  ? 233 ASP B CB  1 
ATOM   3534 C CG  . ASP B 2 233 ? 195.164 237.123 361.482 1.00 98.82  ? 233 ASP B CG  1 
ATOM   3535 O OD1 . ASP B 2 233 ? 194.921 237.103 362.706 1.00 98.73  ? 233 ASP B OD1 1 
ATOM   3536 O OD2 . ASP B 2 233 ? 196.095 236.473 360.962 1.00 97.24  ? 233 ASP B OD2 1 
ATOM   3537 N N   . ASN B 2 234 ? 192.954 240.017 363.357 1.00 100.48 ? 234 ASN B N   1 
ATOM   3538 C CA  . ASN B 2 234 ? 193.292 241.089 364.285 1.00 102.92 ? 234 ASN B CA  1 
ATOM   3539 C C   . ASN B 2 234 ? 194.539 240.787 365.105 1.00 104.70 ? 234 ASN B C   1 
ATOM   3540 O O   . ASN B 2 234 ? 195.117 241.709 365.689 1.00 103.91 ? 234 ASN B O   1 
ATOM   3541 C CB  . ASN B 2 234 ? 192.113 241.354 365.221 1.00 103.17 ? 234 ASN B CB  1 
ATOM   3542 C CG  . ASN B 2 234 ? 190.824 241.617 364.471 1.00 104.24 ? 234 ASN B CG  1 
ATOM   3543 O OD1 . ASN B 2 234 ? 190.025 240.708 364.250 1.00 103.67 ? 234 ASN B OD1 1 
ATOM   3544 N ND2 . ASN B 2 234 ? 190.616 242.866 364.072 1.00 102.00 ? 234 ASN B ND2 1 
ATOM   3545 N N   . ASN B 2 235 ? 194.968 239.527 365.168 1.00 108.20 ? 235 ASN B N   1 
ATOM   3546 C CA  . ASN B 2 235 ? 196.149 239.176 365.947 1.00 108.35 ? 235 ASN B CA  1 
ATOM   3547 C C   . ASN B 2 235 ? 197.380 239.880 365.390 1.00 109.06 ? 235 ASN B C   1 
ATOM   3548 O O   . ASN B 2 235 ? 197.853 239.547 364.299 1.00 104.58 ? 235 ASN B O   1 
ATOM   3549 C CB  . ASN B 2 235 ? 196.357 237.661 365.950 1.00 105.63 ? 235 ASN B CB  1 
ATOM   3550 C CG  . ASN B 2 235 ? 197.574 237.242 366.751 1.00 106.95 ? 235 ASN B CG  1 
ATOM   3551 O OD1 . ASN B 2 235 ? 198.087 238.006 367.568 1.00 108.47 ? 235 ASN B OD1 1 
ATOM   3552 N ND2 . ASN B 2 235 ? 198.043 236.022 366.519 1.00 105.73 ? 235 ASN B ND2 1 
ATOM   3553 N N   . GLN B 2 236 ? 197.906 240.852 366.135 1.00 108.82 ? 236 GLN B N   1 
ATOM   3554 C CA  . GLN B 2 236 ? 199.058 241.627 365.694 1.00 107.09 ? 236 GLN B CA  1 
ATOM   3555 C C   . GLN B 2 236 ? 200.384 241.063 366.184 1.00 106.89 ? 236 GLN B C   1 
ATOM   3556 O O   . GLN B 2 236 ? 201.438 241.558 365.771 1.00 104.82 ? 236 GLN B O   1 
ATOM   3557 C CB  . GLN B 2 236 ? 198.925 243.080 366.164 1.00 105.83 ? 236 GLN B CB  1 
ATOM   3558 C CG  . GLN B 2 236 ? 197.611 243.741 365.780 1.00 105.40 ? 236 GLN B CG  1 
ATOM   3559 C CD  . GLN B 2 236 ? 197.359 243.721 364.285 1.00 105.92 ? 236 GLN B CD  1 
ATOM   3560 O OE1 . GLN B 2 236 ? 198.289 243.599 363.488 1.00 105.72 ? 236 GLN B OE1 1 
ATOM   3561 N NE2 . GLN B 2 236 ? 196.094 243.836 363.897 1.00 105.34 ? 236 GLN B NE2 1 
ATOM   3562 N N   . THR B 2 237 ? 200.362 240.049 367.048 1.00 112.64 ? 237 THR B N   1 
ATOM   3563 C CA  . THR B 2 237 ? 201.591 239.448 367.558 1.00 113.48 ? 237 THR B CA  1 
ATOM   3564 C C   . THR B 2 237 ? 202.115 238.374 366.609 1.00 112.13 ? 237 THR B C   1 
ATOM   3565 O O   . THR B 2 237 ? 203.267 238.432 366.167 1.00 110.50 ? 237 THR B O   1 
ATOM   3566 C CB  . THR B 2 237 ? 201.348 238.858 368.953 1.00 111.94 ? 237 THR B CB  1 
ATOM   3567 O OG1 . THR B 2 237 ? 201.037 239.910 369.874 1.00 111.95 ? 237 THR B OG1 1 
ATOM   3568 C CG2 . THR B 2 237 ? 202.578 238.103 369.441 1.00 109.26 ? 237 THR B CG2 1 
ATOM   3569 N N   . SER B 2 238 ? 201.277 237.390 366.288 1.00 107.18 ? 238 SER B N   1 
ATOM   3570 C CA  . SER B 2 238 ? 201.637 236.287 365.398 1.00 106.68 ? 238 SER B CA  1 
ATOM   3571 C C   . SER B 2 238 ? 200.562 236.178 364.326 1.00 108.02 ? 238 SER B C   1 
ATOM   3572 O O   . SER B 2 238 ? 199.652 235.344 364.425 1.00 106.65 ? 238 SER B O   1 
ATOM   3573 C CB  . SER B 2 238 ? 201.782 234.976 366.172 1.00 105.73 ? 238 SER B CB  1 
ATOM   3574 O OG  . SER B 2 238 ? 202.162 233.918 365.310 1.00 105.23 ? 238 SER B OG  1 
ATOM   3575 N N   . PRO B 2 239 ? 200.630 237.010 363.287 1.00 102.82 ? 239 PRO B N   1 
ATOM   3576 C CA  . PRO B 2 239 ? 199.590 236.968 362.253 1.00 100.36 ? 239 PRO B CA  1 
ATOM   3577 C C   . PRO B 2 239 ? 199.508 235.594 361.606 1.00 95.53  ? 239 PRO B C   1 
ATOM   3578 O O   . PRO B 2 239 ? 200.521 234.935 361.369 1.00 93.27  ? 239 PRO B O   1 
ATOM   3579 C CB  . PRO B 2 239 ? 200.036 238.041 361.253 1.00 99.36  ? 239 PRO B CB  1 
ATOM   3580 C CG  . PRO B 2 239 ? 201.493 238.222 361.501 1.00 98.08  ? 239 PRO B CG  1 
ATOM   3581 C CD  . PRO B 2 239 ? 201.690 237.980 362.962 1.00 98.95  ? 239 PRO B CD  1 
ATOM   3582 N N   . ALA B 2 240 ? 198.277 235.164 361.323 1.00 89.07  ? 240 ALA B N   1 
ATOM   3583 C CA  . ALA B 2 240 ? 198.066 233.849 360.734 1.00 88.79  ? 240 ALA B CA  1 
ATOM   3584 C C   . ALA B 2 240 ? 198.575 233.765 359.302 1.00 88.07  ? 240 ALA B C   1 
ATOM   3585 O O   . ALA B 2 240 ? 198.854 232.661 358.825 1.00 85.76  ? 240 ALA B O   1 
ATOM   3586 C CB  . ALA B 2 240 ? 196.582 233.488 360.775 1.00 86.54  ? 240 ALA B CB  1 
ATOM   3587 N N   . ARG B 2 241 ? 198.705 234.896 358.612 1.00 84.07  ? 241 ARG B N   1 
ATOM   3588 C CA  . ARG B 2 241 ? 199.179 234.918 357.231 1.00 82.48  ? 241 ARG B CA  1 
ATOM   3589 C C   . ARG B 2 241 ? 198.405 233.908 356.388 1.00 81.78  ? 241 ARG B C   1 
ATOM   3590 O O   . ARG B 2 241 ? 198.978 233.054 355.708 1.00 80.16  ? 241 ARG B O   1 
ATOM   3591 C CB  . ARG B 2 241 ? 200.682 234.645 357.170 1.00 81.58  ? 241 ARG B CB  1 
ATOM   3592 C CG  . ARG B 2 241 ? 201.497 235.482 358.139 1.00 80.99  ? 241 ARG B CG  1 
ATOM   3593 C CD  . ARG B 2 241 ? 202.983 235.203 358.006 1.00 80.11  ? 241 ARG B CD  1 
ATOM   3594 N NE  . ARG B 2 241 ? 203.504 235.624 356.712 1.00 80.86  ? 241 ARG B NE  1 
ATOM   3595 C CZ  . ARG B 2 241 ? 204.762 235.466 356.324 1.00 80.57  ? 241 ARG B CZ  1 
ATOM   3596 N NH1 . ARG B 2 241 ? 205.660 234.892 357.107 1.00 82.47  ? 241 ARG B NH1 1 
ATOM   3597 N NH2 . ARG B 2 241 ? 205.127 235.894 355.119 1.00 79.23  ? 241 ARG B NH2 1 
ATOM   3598 N N   . ARG B 2 242 ? 197.081 234.011 356.443 1.00 76.81  ? 242 ARG B N   1 
ATOM   3599 C CA  . ARG B 2 242 ? 196.188 233.015 355.872 1.00 76.58  ? 242 ARG B CA  1 
ATOM   3600 C C   . ARG B 2 242 ? 195.188 233.690 354.947 1.00 75.29  ? 242 ARG B C   1 
ATOM   3601 O O   . ARG B 2 242 ? 194.701 234.786 355.240 1.00 78.38  ? 242 ARG B O   1 
ATOM   3602 C CB  . ARG B 2 242 ? 195.457 232.261 356.986 1.00 77.95  ? 242 ARG B CB  1 
ATOM   3603 C CG  . ARG B 2 242 ? 195.112 230.820 356.669 1.00 79.70  ? 242 ARG B CG  1 
ATOM   3604 C CD  . ARG B 2 242 ? 194.997 230.018 357.952 1.00 81.12  ? 242 ARG B CD  1 
ATOM   3605 N NE  . ARG B 2 242 ? 194.229 230.734 358.963 1.00 86.57  ? 242 ARG B NE  1 
ATOM   3606 C CZ  . ARG B 2 242 ? 194.207 230.424 360.252 1.00 85.28  ? 242 ARG B CZ  1 
ATOM   3607 N NH1 . ARG B 2 242 ? 194.910 229.411 360.733 1.00 82.42  ? 242 ARG B NH1 1 
ATOM   3608 N NH2 . ARG B 2 242 ? 193.466 231.152 361.082 1.00 83.54  ? 242 ARG B NH2 1 
ATOM   3609 N N   . PHE B 2 243 ? 194.886 233.034 353.829 1.00 65.03  ? 243 PHE B N   1 
ATOM   3610 C CA  . PHE B 2 243 ? 193.908 233.570 352.892 1.00 63.88  ? 243 PHE B CA  1 
ATOM   3611 C C   . PHE B 2 243 ? 192.540 233.685 353.551 1.00 71.36  ? 243 PHE B C   1 
ATOM   3612 O O   . PHE B 2 243 ? 192.138 232.827 354.342 1.00 74.03  ? 243 PHE B O   1 
ATOM   3613 C CB  . PHE B 2 243 ? 193.804 232.672 351.658 1.00 64.74  ? 243 PHE B CB  1 
ATOM   3614 C CG  . PHE B 2 243 ? 194.921 232.840 350.666 1.00 60.84  ? 243 PHE B CG  1 
ATOM   3615 C CD1 . PHE B 2 243 ? 195.563 234.053 350.501 1.00 65.11  ? 243 PHE B CD1 1 
ATOM   3616 C CD2 . PHE B 2 243 ? 195.313 231.774 349.880 1.00 64.17  ? 243 PHE B CD2 1 
ATOM   3617 C CE1 . PHE B 2 243 ? 196.578 234.192 349.582 1.00 68.26  ? 243 PHE B CE1 1 
ATOM   3618 C CE2 . PHE B 2 243 ? 196.327 231.909 348.961 1.00 63.65  ? 243 PHE B CE2 1 
ATOM   3619 C CZ  . PHE B 2 243 ? 196.959 233.119 348.812 1.00 66.23  ? 243 PHE B CZ  1 
ATOM   3620 N N   . CYS B 2 244 ? 191.823 234.757 353.220 1.00 78.69  ? 244 CYS B N   1 
ATOM   3621 C CA  . CYS B 2 244 ? 190.438 234.952 353.653 1.00 81.80  ? 244 CYS B CA  1 
ATOM   3622 C C   . CYS B 2 244 ? 189.623 235.461 352.473 1.00 81.19  ? 244 CYS B C   1 
ATOM   3623 O O   . CYS B 2 244 ? 189.169 236.610 352.457 1.00 82.99  ? 244 CYS B O   1 
ATOM   3624 C CB  . CYS B 2 244 ? 190.368 235.922 354.833 1.00 83.40  ? 244 CYS B CB  1 
ATOM   3625 S SG  . CYS B 2 244 ? 188.703 236.160 355.491 1.00 90.17  ? 244 CYS B SG  1 
ATOM   3626 N N   . PRO B 2 245 ? 189.414 234.620 351.457 1.00 66.87  ? 245 PRO B N   1 
ATOM   3627 C CA  . PRO B 2 245 ? 188.689 235.059 350.256 1.00 65.94  ? 245 PRO B CA  1 
ATOM   3628 C C   . PRO B 2 245 ? 187.184 235.010 350.476 1.00 61.88  ? 245 PRO B C   1 
ATOM   3629 O O   . PRO B 2 245 ? 186.632 233.966 350.828 1.00 64.69  ? 245 PRO B O   1 
ATOM   3630 C CB  . PRO B 2 245 ? 189.136 234.052 349.192 1.00 60.29  ? 245 PRO B CB  1 
ATOM   3631 C CG  . PRO B 2 245 ? 189.393 232.809 349.965 1.00 56.54  ? 245 PRO B CG  1 
ATOM   3632 C CD  . PRO B 2 245 ? 189.886 233.230 351.329 1.00 58.53  ? 245 PRO B CD  1 
ATOM   3633 N N   . VAL B 2 246 ? 186.521 236.140 350.262 1.00 61.79  ? 246 VAL B N   1 
ATOM   3634 C CA  . VAL B 2 246 ? 185.071 236.211 350.400 1.00 60.61  ? 246 VAL B CA  1 
ATOM   3635 C C   . VAL B 2 246 ? 184.431 235.536 349.197 1.00 64.48  ? 246 VAL B C   1 
ATOM   3636 O O   . VAL B 2 246 ? 184.907 235.668 348.064 1.00 65.52  ? 246 VAL B O   1 
ATOM   3637 C CB  . VAL B 2 246 ? 184.612 237.672 350.541 1.00 60.23  ? 246 VAL B CB  1 
ATOM   3638 C CG1 . VAL B 2 246 ? 183.137 237.730 350.878 1.00 57.88  ? 246 VAL B CG1 1 
ATOM   3639 C CG2 . VAL B 2 246 ? 185.428 238.381 351.607 1.00 63.85  ? 246 VAL B CG2 1 
ATOM   3640 N N   . ASP B 2 247 ? 183.342 234.803 349.440 1.00 67.18  ? 247 ASP B N   1 
ATOM   3641 C CA  . ASP B 2 247 ? 182.794 233.926 348.409 1.00 61.30  ? 247 ASP B CA  1 
ATOM   3642 C C   . ASP B 2 247 ? 182.318 234.715 347.196 1.00 59.17  ? 247 ASP B C   1 
ATOM   3643 O O   . ASP B 2 247 ? 182.674 234.394 346.057 1.00 55.74  ? 247 ASP B O   1 
ATOM   3644 C CB  . ASP B 2 247 ? 181.655 233.085 348.987 1.00 60.96  ? 247 ASP B CB  1 
ATOM   3645 C CG  . ASP B 2 247 ? 180.510 233.927 349.507 1.00 66.21  ? 247 ASP B CG  1 
ATOM   3646 O OD1 . ASP B 2 247 ? 180.611 235.169 349.454 1.00 68.15  ? 247 ASP B OD1 1 
ATOM   3647 O OD2 . ASP B 2 247 ? 179.505 233.344 349.966 1.00 66.41  ? 247 ASP B OD2 1 
ATOM   3648 N N   . TYR B 2 248 ? 181.514 235.757 347.416 1.00 59.81  ? 248 TYR B N   1 
ATOM   3649 C CA  . TYR B 2 248 ? 180.923 236.461 346.282 1.00 59.59  ? 248 TYR B CA  1 
ATOM   3650 C C   . TYR B 2 248 ? 181.943 237.333 345.566 1.00 60.12  ? 248 TYR B C   1 
ATOM   3651 O O   . TYR B 2 248 ? 181.804 237.582 344.364 1.00 58.37  ? 248 TYR B O   1 
ATOM   3652 C CB  . TYR B 2 248 ? 179.729 237.298 346.737 1.00 52.82  ? 248 TYR B CB  1 
ATOM   3653 C CG  . TYR B 2 248 ? 180.063 238.424 347.685 1.00 54.07  ? 248 TYR B CG  1 
ATOM   3654 C CD1 . TYR B 2 248 ? 180.111 238.213 349.054 1.00 55.52  ? 248 TYR B CD1 1 
ATOM   3655 C CD2 . TYR B 2 248 ? 180.307 239.704 347.213 1.00 55.80  ? 248 TYR B CD2 1 
ATOM   3656 C CE1 . TYR B 2 248 ? 180.404 239.241 349.924 1.00 57.43  ? 248 TYR B CE1 1 
ATOM   3657 C CE2 . TYR B 2 248 ? 180.599 240.739 348.076 1.00 55.91  ? 248 TYR B CE2 1 
ATOM   3658 C CZ  . TYR B 2 248 ? 180.647 240.501 349.430 1.00 56.92  ? 248 TYR B CZ  1 
ATOM   3659 O OH  . TYR B 2 248 ? 180.940 241.528 350.294 1.00 59.50  ? 248 TYR B OH  1 
ATOM   3660 N N   . LEU B 2 249 ? 182.968 237.804 346.275 1.00 57.15  ? 249 LEU B N   1 
ATOM   3661 C CA  . LEU B 2 249 ? 184.042 238.545 345.630 1.00 54.24  ? 249 LEU B CA  1 
ATOM   3662 C C   . LEU B 2 249 ? 185.023 237.639 344.902 1.00 52.59  ? 249 LEU B C   1 
ATOM   3663 O O   . LEU B 2 249 ? 185.885 238.145 344.176 1.00 55.79  ? 249 LEU B O   1 
ATOM   3664 C CB  . LEU B 2 249 ? 184.800 239.388 346.657 1.00 54.29  ? 249 LEU B CB  1 
ATOM   3665 C CG  . LEU B 2 249 ? 184.065 240.618 347.190 1.00 53.02  ? 249 LEU B CG  1 
ATOM   3666 C CD1 . LEU B 2 249 ? 184.878 241.298 348.270 1.00 54.68  ? 249 LEU B CD1 1 
ATOM   3667 C CD2 . LEU B 2 249 ? 183.755 241.596 346.069 1.00 53.88  ? 249 LEU B CD2 1 
ATOM   3668 N N   . LEU B 2 250 ? 184.915 236.325 345.075 1.00 45.99  ? 250 LEU B N   1 
ATOM   3669 C CA  . LEU B 2 250 ? 185.794 235.338 344.460 1.00 48.38  ? 250 LEU B CA  1 
ATOM   3670 C C   . LEU B 2 250 ? 187.200 235.371 345.042 1.00 49.47  ? 250 LEU B C   1 
ATOM   3671 O O   . LEU B 2 250 ? 188.084 234.662 344.546 1.00 52.41  ? 250 LEU B O   1 
ATOM   3672 C CB  . LEU B 2 250 ? 185.870 235.523 342.941 1.00 43.95  ? 250 LEU B CB  1 
ATOM   3673 C CG  . LEU B 2 250 ? 186.229 234.277 342.132 1.00 43.39  ? 250 LEU B CG  1 
ATOM   3674 C CD1 . LEU B 2 250 ? 185.104 233.260 342.182 1.00 45.52  ? 250 LEU B CD1 1 
ATOM   3675 C CD2 . LEU B 2 250 ? 186.545 234.649 340.698 1.00 43.94  ? 250 LEU B CD2 1 
ATOM   3676 N N   . GLY B 2 251 ? 187.432 236.160 346.073 1.00 50.78  ? 251 GLY B N   1 
ATOM   3677 C CA  . GLY B 2 251 ? 188.751 236.266 346.683 1.00 51.12  ? 251 GLY B CA  1 
ATOM   3678 C C   . GLY B 2 251 ? 189.614 237.362 346.102 1.00 51.10  ? 251 GLY B C   1 
ATOM   3679 O O   . GLY B 2 251 ? 190.229 238.127 346.842 1.00 57.65  ? 251 GLY B O   1 
ATOM   3680 N N   . ASN B 2 252 ? 189.663 237.454 344.773 1.00 50.09  ? 252 ASN B N   1 
ATOM   3681 C CA  . ASN B 2 252 ? 190.507 238.450 344.124 1.00 52.17  ? 252 ASN B CA  1 
ATOM   3682 C C   . ASN B 2 252 ? 190.055 239.873 344.408 1.00 56.80  ? 252 ASN B C   1 
ATOM   3683 O O   . ASN B 2 252 ? 190.841 240.807 344.222 1.00 67.45  ? 252 ASN B O   1 
ATOM   3684 C CB  . ASN B 2 252 ? 190.523 238.220 342.614 1.00 52.44  ? 252 ASN B CB  1 
ATOM   3685 C CG  . ASN B 2 252 ? 191.101 236.877 342.236 1.00 57.82  ? 252 ASN B CG  1 
ATOM   3686 O OD1 . ASN B 2 252 ? 192.305 236.746 342.027 1.00 59.82  ? 252 ASN B OD1 1 
ATOM   3687 N ND2 . ASN B 2 252 ? 190.243 235.869 342.141 1.00 59.00  ? 252 ASN B ND2 1 
ATOM   3688 N N   . GLY B 2 253 ? 188.816 240.064 344.849 1.00 45.94  ? 253 GLY B N   1 
ATOM   3689 C CA  . GLY B 2 253 ? 188.243 241.382 345.001 1.00 43.86  ? 253 GLY B CA  1 
ATOM   3690 C C   . GLY B 2 253 ? 187.287 241.772 343.896 1.00 41.61  ? 253 GLY B C   1 
ATOM   3691 O O   . GLY B 2 253 ? 186.617 242.804 344.014 1.00 47.64  ? 253 GLY B O   1 
ATOM   3692 N N   . THR B 2 254 ? 187.205 240.982 342.833 1.00 47.67  ? 254 THR B N   1 
ATOM   3693 C CA  . THR B 2 254 ? 186.253 241.220 341.758 1.00 51.58  ? 254 THR B CA  1 
ATOM   3694 C C   . THR B 2 254 ? 184.881 240.718 342.202 1.00 57.45  ? 254 THR B C   1 
ATOM   3695 O O   . THR B 2 254 ? 184.655 240.430 343.380 1.00 62.19  ? 254 THR B O   1 
ATOM   3696 C CB  . THR B 2 254 ? 186.723 240.538 340.478 1.00 58.79  ? 254 THR B CB  1 
ATOM   3697 O OG1 . THR B 2 254 ? 186.684 239.117 340.652 1.00 64.03  ? 254 THR B OG1 1 
ATOM   3698 C CG2 . THR B 2 254 ? 188.144 240.959 340.137 1.00 56.36  ? 254 THR B CG2 1 
ATOM   3699 N N   . LEU B 2 255 ? 183.941 240.617 341.268 1.00 52.36  ? 255 LEU B N   1 
ATOM   3700 C CA  . LEU B 2 255 ? 182.616 240.084 341.546 1.00 48.70  ? 255 LEU B CA  1 
ATOM   3701 C C   . LEU B 2 255 ? 182.487 238.676 340.984 1.00 49.71  ? 255 LEU B C   1 
ATOM   3702 O O   . LEU B 2 255 ? 183.123 238.326 339.987 1.00 52.54  ? 255 LEU B O   1 
ATOM   3703 C CB  . LEU B 2 255 ? 181.518 240.973 340.952 1.00 50.46  ? 255 LEU B CB  1 
ATOM   3704 C CG  . LEU B 2 255 ? 180.990 242.115 341.824 1.00 49.01  ? 255 LEU B CG  1 
ATOM   3705 C CD1 . LEU B 2 255 ? 179.903 242.867 341.084 1.00 47.93  ? 255 LEU B CD1 1 
ATOM   3706 C CD2 . LEU B 2 255 ? 180.465 241.597 343.152 1.00 51.31  ? 255 LEU B CD2 1 
ATOM   3707 N N   . LEU B 2 256 ? 181.655 237.866 341.642 1.00 54.26  ? 256 LEU B N   1 
ATOM   3708 C CA  . LEU B 2 256 ? 181.437 236.500 341.178 1.00 45.99  ? 256 LEU B CA  1 
ATOM   3709 C C   . LEU B 2 256 ? 180.727 236.479 339.832 1.00 46.33  ? 256 LEU B C   1 
ATOM   3710 O O   . LEU B 2 256 ? 181.049 235.655 338.968 1.00 45.89  ? 256 LEU B O   1 
ATOM   3711 C CB  . LEU B 2 256 ? 180.634 235.714 342.211 1.00 43.48  ? 256 LEU B CB  1 
ATOM   3712 C CG  . LEU B 2 256 ? 180.174 234.328 341.750 1.00 54.00  ? 256 LEU B CG  1 
ATOM   3713 C CD1 . LEU B 2 256 ? 181.360 233.487 341.313 1.00 53.82  ? 256 LEU B CD1 1 
ATOM   3714 C CD2 . LEU B 2 256 ? 179.402 233.625 342.845 1.00 43.33  ? 256 LEU B CD2 1 
ATOM   3715 N N   . GLY B 2 257 ? 179.757 237.371 339.635 1.00 54.87  ? 257 GLY B N   1 
ATOM   3716 C CA  . GLY B 2 257 ? 178.985 237.343 338.404 1.00 54.70  ? 257 GLY B CA  1 
ATOM   3717 C C   . GLY B 2 257 ? 179.857 237.435 337.169 1.00 53.57  ? 257 GLY B C   1 
ATOM   3718 O O   . GLY B 2 257 ? 179.639 236.722 336.189 1.00 56.62  ? 257 GLY B O   1 
ATOM   3719 N N   . ASN B 2 258 ? 180.859 238.314 337.199 1.00 45.70  ? 258 ASN B N   1 
ATOM   3720 C CA  . ASN B 2 258 ? 181.771 238.461 336.073 1.00 41.71  ? 258 ASN B CA  1 
ATOM   3721 C C   . ASN B 2 258 ? 182.747 237.300 335.953 1.00 46.49  ? 258 ASN B C   1 
ATOM   3722 O O   . ASN B 2 258 ? 183.371 237.147 334.897 1.00 43.23  ? 258 ASN B O   1 
ATOM   3723 C CB  . ASN B 2 258 ? 182.547 239.769 336.206 1.00 40.67  ? 258 ASN B CB  1 
ATOM   3724 C CG  . ASN B 2 258 ? 181.645 240.962 336.406 1.00 49.90  ? 258 ASN B CG  1 
ATOM   3725 O OD1 . ASN B 2 258 ? 180.491 240.958 335.985 1.00 57.35  ? 258 ASN B OD1 1 
ATOM   3726 N ND2 . ASN B 2 258 ? 182.167 241.993 337.055 1.00 50.69  ? 258 ASN B ND2 1 
ATOM   3727 N N   . ALA B 2 259 ? 182.878 236.470 336.990 1.00 50.39  ? 259 ALA B N   1 
ATOM   3728 C CA  . ALA B 2 259 ? 183.853 235.386 336.975 1.00 52.01  ? 259 ALA B CA  1 
ATOM   3729 C C   . ALA B 2 259 ? 183.673 234.445 335.794 1.00 51.56  ? 259 ALA B C   1 
ATOM   3730 O O   . ALA B 2 259 ? 184.551 233.611 335.552 1.00 46.85  ? 259 ALA B O   1 
ATOM   3731 C CB  . ALA B 2 259 ? 183.766 234.588 338.275 1.00 48.83  ? 259 ALA B CB  1 
ATOM   3732 N N   . PHE B 2 260 ? 182.568 234.552 335.059 1.00 45.35  ? 260 PHE B N   1 
ATOM   3733 C CA  . PHE B 2 260 ? 182.354 233.712 333.892 1.00 42.06  ? 260 PHE B CA  1 
ATOM   3734 C C   . PHE B 2 260 ? 183.270 234.072 332.733 1.00 42.50  ? 260 PHE B C   1 
ATOM   3735 O O   . PHE B 2 260 ? 183.308 233.328 331.747 1.00 43.42  ? 260 PHE B O   1 
ATOM   3736 C CB  . PHE B 2 260 ? 180.892 233.800 333.457 1.00 39.41  ? 260 PHE B CB  1 
ATOM   3737 C CG  . PHE B 2 260 ? 179.944 233.141 334.413 1.00 41.24  ? 260 PHE B CG  1 
ATOM   3738 C CD1 . PHE B 2 260 ? 179.693 233.698 335.653 1.00 43.59  ? 260 PHE B CD1 1 
ATOM   3739 C CD2 . PHE B 2 260 ? 179.310 231.963 334.075 1.00 40.36  ? 260 PHE B CD2 1 
ATOM   3740 C CE1 . PHE B 2 260 ? 178.830 233.092 336.534 1.00 45.10  ? 260 PHE B CE1 1 
ATOM   3741 C CE2 . PHE B 2 260 ? 178.444 231.354 334.953 1.00 43.90  ? 260 PHE B CE2 1 
ATOM   3742 C CZ  . PHE B 2 260 ? 178.203 231.920 336.184 1.00 47.11  ? 260 PHE B CZ  1 
ATOM   3743 N N   . VAL B 2 261 ? 184.004 235.184 332.817 1.00 35.90  ? 261 VAL B N   1 
ATOM   3744 C CA  . VAL B 2 261 ? 184.986 235.482 331.778 1.00 36.03  ? 261 VAL B CA  1 
ATOM   3745 C C   . VAL B 2 261 ? 186.063 234.408 331.747 1.00 47.27  ? 261 VAL B C   1 
ATOM   3746 O O   . VAL B 2 261 ? 186.578 234.063 330.677 1.00 53.20  ? 261 VAL B O   1 
ATOM   3747 C CB  . VAL B 2 261 ? 185.592 236.884 331.984 1.00 37.87  ? 261 VAL B CB  1 
ATOM   3748 C CG1 . VAL B 2 261 ? 184.527 237.948 331.814 1.00 43.37  ? 261 VAL B CG1 1 
ATOM   3749 C CG2 . VAL B 2 261 ? 186.250 236.995 333.348 1.00 46.00  ? 261 VAL B CG2 1 
ATOM   3750 N N   . PHE B 2 262 ? 186.419 233.862 332.907 1.00 39.14  ? 262 PHE B N   1 
ATOM   3751 C CA  . PHE B 2 262 ? 187.371 232.771 332.964 1.00 31.50  ? 262 PHE B CA  1 
ATOM   3752 C C   . PHE B 2 262 ? 186.793 231.536 332.282 1.00 38.87  ? 262 PHE B C   1 
ATOM   3753 O O   . PHE B 2 262 ? 185.575 231.408 332.143 1.00 47.12  ? 262 PHE B O   1 
ATOM   3754 C CB  . PHE B 2 262 ? 187.706 232.434 334.412 1.00 34.46  ? 262 PHE B CB  1 
ATOM   3755 C CG  . PHE B 2 262 ? 188.406 233.532 335.149 1.00 35.16  ? 262 PHE B CG  1 
ATOM   3756 C CD1 . PHE B 2 262 ? 189.516 234.150 334.609 1.00 35.12  ? 262 PHE B CD1 1 
ATOM   3757 C CD2 . PHE B 2 262 ? 187.956 233.942 336.388 1.00 34.60  ? 262 PHE B CD2 1 
ATOM   3758 C CE1 . PHE B 2 262 ? 190.159 235.154 335.291 1.00 41.00  ? 262 PHE B CE1 1 
ATOM   3759 C CE2 . PHE B 2 262 ? 188.597 234.946 337.072 1.00 31.06  ? 262 PHE B CE2 1 
ATOM   3760 C CZ  . PHE B 2 262 ? 189.701 235.548 336.525 1.00 36.82  ? 262 PHE B CZ  1 
ATOM   3761 N N   . PRO B 2 263 ? 187.643 230.614 331.838 1.00 40.40  ? 263 PRO B N   1 
ATOM   3762 C CA  . PRO B 2 263 ? 187.125 229.323 331.378 1.00 39.72  ? 263 PRO B CA  1 
ATOM   3763 C C   . PRO B 2 263 ? 186.317 228.682 332.490 1.00 39.67  ? 263 PRO B C   1 
ATOM   3764 O O   . PRO B 2 263 ? 186.721 228.687 333.654 1.00 47.49  ? 263 PRO B O   1 
ATOM   3765 C CB  . PRO B 2 263 ? 188.388 228.521 331.052 1.00 38.47  ? 263 PRO B CB  1 
ATOM   3766 C CG  . PRO B 2 263 ? 189.454 229.534 330.874 1.00 46.63  ? 263 PRO B CG  1 
ATOM   3767 C CD  . PRO B 2 263 ? 189.111 230.664 331.786 1.00 46.05  ? 263 PRO B CD  1 
ATOM   3768 N N   . HIS B 2 264 ? 185.156 228.143 332.137 1.00 41.27  ? 264 HIS B N   1 
ATOM   3769 C CA  . HIS B 2 264 ? 184.237 227.707 333.175 1.00 46.90  ? 264 HIS B CA  1 
ATOM   3770 C C   . HIS B 2 264 ? 183.253 226.696 332.616 1.00 48.16  ? 264 HIS B C   1 
ATOM   3771 O O   . HIS B 2 264 ? 183.052 226.592 331.404 1.00 55.07  ? 264 HIS B O   1 
ATOM   3772 C CB  . HIS B 2 264 ? 183.471 228.891 333.764 1.00 46.77  ? 264 HIS B CB  1 
ATOM   3773 C CG  . HIS B 2 264 ? 182.430 229.441 332.843 1.00 44.77  ? 264 HIS B CG  1 
ATOM   3774 N ND1 . HIS B 2 264 ? 182.744 230.075 331.661 1.00 45.04  ? 264 HIS B ND1 1 
ATOM   3775 C CD2 . HIS B 2 264 ? 181.080 229.440 332.923 1.00 47.52  ? 264 HIS B CD2 1 
ATOM   3776 C CE1 . HIS B 2 264 ? 181.631 230.447 331.055 1.00 46.78  ? 264 HIS B CE1 1 
ATOM   3777 N NE2 . HIS B 2 264 ? 180.607 230.074 331.799 1.00 51.26  ? 264 HIS B NE2 1 
ATOM   3778 N N   . GLN B 2 265 ? 182.642 225.956 333.534 1.00 43.89  ? 265 GLN B N   1 
ATOM   3779 C CA  . GLN B 2 265 ? 181.481 225.136 333.236 1.00 47.01  ? 265 GLN B CA  1 
ATOM   3780 C C   . GLN B 2 265 ? 180.551 225.170 334.437 1.00 50.89  ? 265 GLN B C   1 
ATOM   3781 O O   . GLN B 2 265 ? 180.920 225.623 335.523 1.00 60.07  ? 265 GLN B O   1 
ATOM   3782 C CB  . GLN B 2 265 ? 181.866 223.696 332.884 1.00 45.60  ? 265 GLN B CB  1 
ATOM   3783 C CG  . GLN B 2 265 ? 182.108 223.473 331.402 1.00 44.34  ? 265 GLN B CG  1 
ATOM   3784 C CD  . GLN B 2 265 ? 181.799 222.057 330.971 1.00 54.27  ? 265 GLN B CD  1 
ATOM   3785 O OE1 . GLN B 2 265 ? 181.652 221.165 331.802 1.00 61.09  ? 265 GLN B OE1 1 
ATOM   3786 N NE2 . GLN B 2 265 ? 181.692 221.843 329.667 1.00 60.56  ? 265 GLN B NE2 1 
ATOM   3787 N N   . ILE B 2 266 ? 179.323 224.710 334.230 1.00 41.74  ? 266 ILE B N   1 
ATOM   3788 C CA  . ILE B 2 266 ? 178.315 224.665 335.279 1.00 42.17  ? 266 ILE B CA  1 
ATOM   3789 C C   . ILE B 2 266 ? 177.809 223.237 335.390 1.00 50.18  ? 266 ILE B C   1 
ATOM   3790 O O   . ILE B 2 266 ? 177.449 222.617 334.383 1.00 59.45  ? 266 ILE B O   1 
ATOM   3791 C CB  . ILE B 2 266 ? 177.156 225.639 335.001 1.00 42.42  ? 266 ILE B CB  1 
ATOM   3792 C CG1 . ILE B 2 266 ? 177.701 227.022 334.650 1.00 45.53  ? 266 ILE B CG1 1 
ATOM   3793 C CG2 . ILE B 2 266 ? 176.238 225.733 336.208 1.00 46.39  ? 266 ILE B CG2 1 
ATOM   3794 C CD1 . ILE B 2 266 ? 176.628 228.063 334.452 1.00 45.58  ? 266 ILE B CD1 1 
ATOM   3795 N N   . ILE B 2 267 ? 177.792 222.721 336.611 1.00 49.22  ? 267 ILE B N   1 
ATOM   3796 C CA  . ILE B 2 267 ? 177.277 221.387 336.901 1.00 43.19  ? 267 ILE B CA  1 
ATOM   3797 C C   . ILE B 2 267 ? 175.889 221.609 337.486 1.00 48.85  ? 267 ILE B C   1 
ATOM   3798 O O   . ILE B 2 267 ? 175.728 221.853 338.680 1.00 59.50  ? 267 ILE B O   1 
ATOM   3799 C CB  . ILE B 2 267 ? 178.191 220.617 337.852 1.00 46.56  ? 267 ILE B CB  1 
ATOM   3800 C CG1 . ILE B 2 267 ? 179.586 220.474 337.242 1.00 50.89  ? 267 ILE B CG1 1 
ATOM   3801 C CG2 . ILE B 2 267 ? 177.602 219.252 338.167 1.00 50.28  ? 267 ILE B CG2 1 
ATOM   3802 C CD1 . ILE B 2 267 ? 180.616 219.935 338.200 1.00 50.67  ? 267 ILE B CD1 1 
ATOM   3803 N N   . ASN B 2 268 ? 174.876 221.555 336.628 1.00 44.14  ? 268 ASN B N   1 
ATOM   3804 C CA  . ASN B 2 268 ? 173.489 221.741 337.034 1.00 41.45  ? 268 ASN B CA  1 
ATOM   3805 C C   . ASN B 2 268 ? 172.885 220.360 337.246 1.00 52.66  ? 268 ASN B C   1 
ATOM   3806 O O   . ASN B 2 268 ? 172.728 219.591 336.292 1.00 61.47  ? 268 ASN B O   1 
ATOM   3807 C CB  . ASN B 2 268 ? 172.718 222.536 335.984 1.00 40.69  ? 268 ASN B CB  1 
ATOM   3808 C CG  . ASN B 2 268 ? 171.406 223.076 336.509 1.00 43.81  ? 268 ASN B CG  1 
ATOM   3809 O OD1 . ASN B 2 268 ? 171.165 223.086 337.714 1.00 44.76  ? 268 ASN B OD1 1 
ATOM   3810 N ND2 . ASN B 2 268 ? 170.551 223.536 335.605 1.00 47.51  ? 268 ASN B ND2 1 
ATOM   3811 N N   . LEU B 2 269 ? 172.541 220.048 338.496 1.00 46.54  ? 269 LEU B N   1 
ATOM   3812 C CA  . LEU B 2 269 ? 172.166 218.682 338.842 1.00 44.92  ? 269 LEU B CA  1 
ATOM   3813 C C   . LEU B 2 269 ? 170.965 218.188 338.051 1.00 50.20  ? 269 LEU B C   1 
ATOM   3814 O O   . LEU B 2 269 ? 170.778 216.974 337.930 1.00 51.29  ? 269 LEU B O   1 
ATOM   3815 C CB  . LEU B 2 269 ? 171.879 218.582 340.339 1.00 48.11  ? 269 LEU B CB  1 
ATOM   3816 C CG  . LEU B 2 269 ? 173.044 218.948 341.259 1.00 47.50  ? 269 LEU B CG  1 
ATOM   3817 C CD1 . LEU B 2 269 ? 172.650 218.760 342.713 1.00 48.10  ? 269 LEU B CD1 1 
ATOM   3818 C CD2 . LEU B 2 269 ? 174.279 218.130 340.927 1.00 46.48  ? 269 LEU B CD2 1 
ATOM   3819 N N   . ARG B 2 270 ? 170.143 219.090 337.512 1.00 53.36  ? 270 ARG B N   1 
ATOM   3820 C CA  . ARG B 2 270 ? 169.024 218.645 336.690 1.00 55.78  ? 270 ARG B CA  1 
ATOM   3821 C C   . ARG B 2 270 ? 169.492 218.140 335.332 1.00 52.92  ? 270 ARG B C   1 
ATOM   3822 O O   . ARG B 2 270 ? 168.869 217.238 334.763 1.00 60.50  ? 270 ARG B O   1 
ATOM   3823 C CB  . ARG B 2 270 ? 168.014 219.777 336.504 1.00 48.75  ? 270 ARG B CB  1 
ATOM   3824 C CG  . ARG B 2 270 ? 168.563 220.975 335.755 1.00 49.23  ? 270 ARG B CG  1 
ATOM   3825 C CD  . ARG B 2 270 ? 167.510 222.048 335.541 1.00 56.73  ? 270 ARG B CD  1 
ATOM   3826 N NE  . ARG B 2 270 ? 166.495 221.649 334.572 1.00 54.95  ? 270 ARG B NE  1 
ATOM   3827 C CZ  . ARG B 2 270 ? 165.306 221.148 334.880 1.00 53.76  ? 270 ARG B CZ  1 
ATOM   3828 N NH1 . ARG B 2 270 ? 164.940 220.950 336.135 1.00 56.38  ? 270 ARG B NH1 1 
ATOM   3829 N NH2 . ARG B 2 270 ? 164.461 220.839 333.902 1.00 50.93  ? 270 ARG B NH2 1 
ATOM   3830 N N   . THR B 2 271 ? 170.577 218.699 334.799 1.00 45.98  ? 271 THR B N   1 
ATOM   3831 C CA  . THR B 2 271 ? 171.015 218.404 333.441 1.00 54.49  ? 271 THR B CA  1 
ATOM   3832 C C   . THR B 2 271 ? 172.250 217.512 333.403 1.00 56.12  ? 271 THR B C   1 
ATOM   3833 O O   . THR B 2 271 ? 172.215 216.441 332.792 1.00 59.47  ? 271 THR B O   1 
ATOM   3834 C CB  . THR B 2 271 ? 171.286 219.715 332.689 1.00 60.75  ? 271 THR B CB  1 
ATOM   3835 O OG1 . THR B 2 271 ? 170.104 220.524 332.698 1.00 60.86  ? 271 THR B OG1 1 
ATOM   3836 C CG2 . THR B 2 271 ? 171.690 219.437 331.251 1.00 58.63  ? 271 THR B CG2 1 
ATOM   3837 N N   . ASN B 2 272 ? 173.345 217.919 334.042 1.00 51.43  ? 272 ASN B N   1 
ATOM   3838 C CA  . ASN B 2 272 ? 174.609 217.205 333.945 1.00 49.83  ? 272 ASN B CA  1 
ATOM   3839 C C   . ASN B 2 272 ? 175.222 217.034 335.325 1.00 46.31  ? 272 ASN B C   1 
ATOM   3840 O O   . ASN B 2 272 ? 174.979 217.829 336.235 1.00 59.60  ? 272 ASN B O   1 
ATOM   3841 C CB  . ASN B 2 272 ? 175.598 217.936 333.036 1.00 49.74  ? 272 ASN B CB  1 
ATOM   3842 C CG  . ASN B 2 272 ? 176.056 219.250 333.619 1.00 52.07  ? 272 ASN B CG  1 
ATOM   3843 O OD1 . ASN B 2 272 ? 175.344 219.875 334.402 1.00 52.76  ? 272 ASN B OD1 1 
ATOM   3844 N ND2 . ASN B 2 272 ? 177.253 219.681 333.242 1.00 50.72  ? 272 ASN B ND2 1 
ATOM   3845 N N   . ASN B 2 273 ? 176.030 215.985 335.464 1.00 40.06  ? 273 ASN B N   1 
ATOM   3846 C CA  . ASN B 2 273 ? 176.681 215.653 336.724 1.00 50.41  ? 273 ASN B CA  1 
ATOM   3847 C C   . ASN B 2 273 ? 178.201 215.710 336.629 1.00 53.52  ? 273 ASN B C   1 
ATOM   3848 O O   . ASN B 2 273 ? 178.884 215.250 337.551 1.00 58.11  ? 273 ASN B O   1 
ATOM   3849 C CB  . ASN B 2 273 ? 176.240 214.263 337.186 1.00 61.73  ? 273 ASN B CB  1 
ATOM   3850 C CG  . ASN B 2 273 ? 176.428 213.210 336.113 1.00 69.89  ? 273 ASN B CG  1 
ATOM   3851 O OD1 . ASN B 2 273 ? 176.524 213.531 334.929 1.00 67.02  ? 273 ASN B OD1 1 
ATOM   3852 N ND2 . ASN B 2 273 ? 176.478 211.947 336.519 1.00 65.28  ? 273 ASN B ND2 1 
ATOM   3853 N N   . CYS B 2 274 ? 178.749 216.257 335.547 1.00 52.53  ? 274 CYS B N   1 
ATOM   3854 C CA  . CYS B 2 274 ? 180.191 216.304 335.362 1.00 47.11  ? 274 CYS B CA  1 
ATOM   3855 C C   . CYS B 2 274 ? 180.563 217.575 334.616 1.00 53.24  ? 274 CYS B C   1 
ATOM   3856 O O   . CYS B 2 274 ? 179.734 218.189 333.941 1.00 64.26  ? 274 CYS B O   1 
ATOM   3857 C CB  . CYS B 2 274 ? 180.700 215.082 334.595 1.00 48.30  ? 274 CYS B CB  1 
ATOM   3858 S SG  . CYS B 2 274 ? 180.213 213.503 335.302 1.00 70.37  ? 274 CYS B SG  1 
ATOM   3859 N N   . ALA B 2 275 ? 181.828 217.962 334.748 1.00 43.23  ? 275 ALA B N   1 
ATOM   3860 C CA  . ALA B 2 275 ? 182.345 219.139 334.058 1.00 47.64  ? 275 ALA B CA  1 
ATOM   3861 C C   . ALA B 2 275 ? 183.799 218.893 333.695 1.00 45.04  ? 275 ALA B C   1 
ATOM   3862 O O   . ALA B 2 275 ? 184.622 218.648 334.580 1.00 54.51  ? 275 ALA B O   1 
ATOM   3863 C CB  . ALA B 2 275 ? 182.213 220.389 334.927 1.00 51.48  ? 275 ALA B CB  1 
ATOM   3864 N N   . THR B 2 276 ? 184.116 218.965 332.407 1.00 40.83  ? 276 THR B N   1 
ATOM   3865 C CA  . THR B 2 276 ? 185.462 218.714 331.910 1.00 45.72  ? 276 THR B CA  1 
ATOM   3866 C C   . THR B 2 276 ? 186.071 220.018 331.416 1.00 52.86  ? 276 THR B C   1 
ATOM   3867 O O   . THR B 2 276 ? 185.435 220.757 330.659 1.00 59.90  ? 276 THR B O   1 
ATOM   3868 C CB  . THR B 2 276 ? 185.446 217.684 330.780 1.00 54.01  ? 276 THR B CB  1 
ATOM   3869 O OG1 . THR B 2 276 ? 184.551 216.619 331.117 1.00 62.23  ? 276 THR B OG1 1 
ATOM   3870 C CG2 . THR B 2 276 ? 186.837 217.114 330.560 1.00 45.66  ? 276 THR B CG2 1 
ATOM   3871 N N   . LEU B 2 277 ? 187.300 220.293 331.846 1.00 44.31  ? 277 LEU B N   1 
ATOM   3872 C CA  . LEU B 2 277 ? 188.031 221.490 331.448 1.00 32.42  ? 277 LEU B CA  1 
ATOM   3873 C C   . LEU B 2 277 ? 189.426 221.085 331.007 1.00 37.91  ? 277 LEU B C   1 
ATOM   3874 O O   . LEU B 2 277 ? 190.179 220.503 331.792 1.00 49.36  ? 277 LEU B O   1 
ATOM   3875 C CB  . LEU B 2 277 ? 188.112 222.491 332.601 1.00 30.12  ? 277 LEU B CB  1 
ATOM   3876 C CG  . LEU B 2 277 ? 186.837 223.266 332.911 1.00 38.77  ? 277 LEU B CG  1 
ATOM   3877 C CD1 . LEU B 2 277 ? 186.805 223.658 334.371 1.00 47.11  ? 277 LEU B CD1 1 
ATOM   3878 C CD2 . LEU B 2 277 ? 186.759 224.494 332.033 1.00 40.44  ? 277 LEU B CD2 1 
ATOM   3879 N N   . VAL B 2 278 ? 189.774 221.393 329.764 1.00 30.75  ? 278 VAL B N   1 
ATOM   3880 C CA  . VAL B 2 278 ? 191.117 221.165 329.245 1.00 31.16  ? 278 VAL B CA  1 
ATOM   3881 C C   . VAL B 2 278 ? 191.847 222.500 329.326 1.00 37.97  ? 278 VAL B C   1 
ATOM   3882 O O   . VAL B 2 278 ? 191.637 223.392 328.501 1.00 45.46  ? 278 VAL B O   1 
ATOM   3883 C CB  . VAL B 2 278 ? 191.091 220.611 327.820 1.00 36.31  ? 278 VAL B CB  1 
ATOM   3884 C CG1 . VAL B 2 278 ? 192.503 220.462 327.289 1.00 42.65  ? 278 VAL B CG1 1 
ATOM   3885 C CG2 . VAL B 2 278 ? 190.366 219.280 327.789 1.00 38.09  ? 278 VAL B CG2 1 
ATOM   3886 N N   . LEU B 2 279 ? 192.710 222.638 330.330 1.00 28.56  ? 279 LEU B N   1 
ATOM   3887 C CA  . LEU B 2 279 ? 193.401 223.886 330.596 1.00 32.05  ? 279 LEU B CA  1 
ATOM   3888 C C   . LEU B 2 279 ? 194.777 223.850 329.954 1.00 40.25  ? 279 LEU B C   1 
ATOM   3889 O O   . LEU B 2 279 ? 195.599 223.007 330.342 1.00 44.07  ? 279 LEU B O   1 
ATOM   3890 C CB  . LEU B 2 279 ? 193.532 224.100 332.097 1.00 33.53  ? 279 LEU B CB  1 
ATOM   3891 C CG  . LEU B 2 279 ? 192.252 223.881 332.903 1.00 33.34  ? 279 LEU B CG  1 
ATOM   3892 C CD1 . LEU B 2 279 ? 192.537 223.940 334.387 1.00 31.12  ? 279 LEU B CD1 1 
ATOM   3893 C CD2 . LEU B 2 279 ? 191.212 224.908 332.521 1.00 44.31  ? 279 LEU B CD2 1 
ATOM   3894 N N   . PRO B 2 280 ? 195.087 224.721 328.992 1.00 41.57  ? 280 PRO B N   1 
ATOM   3895 C CA  . PRO B 2 280 ? 196.446 224.742 328.443 1.00 34.89  ? 280 PRO B CA  1 
ATOM   3896 C C   . PRO B 2 280 ? 197.422 225.360 329.423 1.00 42.55  ? 280 PRO B C   1 
ATOM   3897 O O   . PRO B 2 280 ? 197.039 225.697 330.546 1.00 59.20  ? 280 PRO B O   1 
ATOM   3898 C CB  . PRO B 2 280 ? 196.296 225.593 327.180 1.00 35.40  ? 280 PRO B CB  1 
ATOM   3899 C CG  . PRO B 2 280 ? 195.204 226.531 327.515 1.00 38.01  ? 280 PRO B CG  1 
ATOM   3900 C CD  . PRO B 2 280 ? 194.243 225.765 328.386 1.00 42.79  ? 280 PRO B CD  1 
ATOM   3901 N N   . TYR B 2 281 ? 198.678 225.519 329.022 1.00 30.73  ? 281 TYR B N   1 
ATOM   3902 C CA  . TYR B 2 281 ? 199.687 226.151 329.861 1.00 31.62  ? 281 TYR B CA  1 
ATOM   3903 C C   . TYR B 2 281 ? 199.769 227.623 329.483 1.00 39.32  ? 281 TYR B C   1 
ATOM   3904 O O   . TYR B 2 281 ? 200.327 227.972 328.438 1.00 39.74  ? 281 TYR B O   1 
ATOM   3905 C CB  . TYR B 2 281 ? 201.041 225.467 329.701 1.00 38.13  ? 281 TYR B CB  1 
ATOM   3906 C CG  . TYR B 2 281 ? 202.129 226.095 330.539 1.00 37.57  ? 281 TYR B CG  1 
ATOM   3907 C CD1 . TYR B 2 281 ? 202.219 225.836 331.897 1.00 38.90  ? 281 TYR B CD1 1 
ATOM   3908 C CD2 . TYR B 2 281 ? 203.062 226.948 329.974 1.00 34.59  ? 281 TYR B CD2 1 
ATOM   3909 C CE1 . TYR B 2 281 ? 203.205 226.409 332.667 1.00 37.52  ? 281 TYR B CE1 1 
ATOM   3910 C CE2 . TYR B 2 281 ? 204.052 227.525 330.736 1.00 36.91  ? 281 TYR B CE2 1 
ATOM   3911 C CZ  . TYR B 2 281 ? 204.119 227.251 332.082 1.00 38.62  ? 281 TYR B CZ  1 
ATOM   3912 O OH  . TYR B 2 281 ? 205.104 227.824 332.849 1.00 43.26  ? 281 TYR B OH  1 
ATOM   3913 N N   . VAL B 2 282 ? 199.216 228.483 330.333 1.00 42.62  ? 282 VAL B N   1 
ATOM   3914 C CA  . VAL B 2 282 ? 199.265 229.928 330.150 1.00 40.08  ? 282 VAL B CA  1 
ATOM   3915 C C   . VAL B 2 282 ? 200.223 230.495 331.185 1.00 49.05  ? 282 VAL B C   1 
ATOM   3916 O O   . VAL B 2 282 ? 200.107 230.195 332.379 1.00 56.15  ? 282 VAL B O   1 
ATOM   3917 C CB  . VAL B 2 282 ? 197.874 230.572 330.281 1.00 38.45  ? 282 VAL B CB  1 
ATOM   3918 C CG1 . VAL B 2 282 ? 196.889 229.905 329.342 1.00 41.30  ? 282 VAL B CG1 1 
ATOM   3919 C CG2 . VAL B 2 282 ? 197.383 230.505 331.716 1.00 40.90  ? 282 VAL B CG2 1 
ATOM   3920 N N   . ASN B 2 283 ? 201.174 231.301 330.727 1.00 41.45  ? 283 ASN B N   1 
ATOM   3921 C CA  . ASN B 2 283 ? 202.154 231.904 331.615 1.00 42.35  ? 283 ASN B CA  1 
ATOM   3922 C C   . ASN B 2 283 ? 202.975 232.897 330.811 1.00 41.48  ? 283 ASN B C   1 
ATOM   3923 O O   . ASN B 2 283 ? 203.172 232.722 329.606 1.00 40.98  ? 283 ASN B O   1 
ATOM   3924 C CB  . ASN B 2 283 ? 203.061 230.842 332.246 1.00 33.62  ? 283 ASN B CB  1 
ATOM   3925 C CG  . ASN B 2 283 ? 203.910 231.392 333.368 1.00 33.31  ? 283 ASN B CG  1 
ATOM   3926 O OD1 . ASN B 2 283 ? 203.699 232.511 333.830 1.00 43.96  ? 283 ASN B OD1 1 
ATOM   3927 N ND2 . ASN B 2 283 ? 204.874 230.602 333.820 1.00 36.44  ? 283 ASN B ND2 1 
ATOM   3928 N N   . SER B 2 284 ? 203.448 233.942 331.490 1.00 43.34  ? 284 SER B N   1 
ATOM   3929 C CA  . SER B 2 284 ? 204.326 234.904 330.839 1.00 41.79  ? 284 SER B CA  1 
ATOM   3930 C C   . SER B 2 284 ? 205.603 234.251 330.340 1.00 47.40  ? 284 SER B C   1 
ATOM   3931 O O   . SER B 2 284 ? 206.271 234.805 329.462 1.00 55.17  ? 284 SER B O   1 
ATOM   3932 C CB  . SER B 2 284 ? 204.678 236.033 331.805 1.00 48.28  ? 284 SER B CB  1 
ATOM   3933 O OG  . SER B 2 284 ? 203.520 236.549 332.432 1.00 51.57  ? 284 SER B OG  1 
ATOM   3934 N N   . LEU B 2 285 ? 205.955 233.092 330.884 1.00 43.45  ? 285 LEU B N   1 
ATOM   3935 C CA  . LEU B 2 285 ? 207.190 232.399 330.568 1.00 40.84  ? 285 LEU B CA  1 
ATOM   3936 C C   . LEU B 2 285 ? 206.860 231.069 329.907 1.00 49.32  ? 285 LEU B C   1 
ATOM   3937 O O   . LEU B 2 285 ? 205.860 230.426 330.239 1.00 51.70  ? 285 LEU B O   1 
ATOM   3938 C CB  . LEU B 2 285 ? 208.019 232.165 331.835 1.00 42.05  ? 285 LEU B CB  1 
ATOM   3939 C CG  . LEU B 2 285 ? 208.038 233.313 332.850 1.00 41.06  ? 285 LEU B CG  1 
ATOM   3940 C CD1 . LEU B 2 285 ? 207.937 232.777 334.262 1.00 46.03  ? 285 LEU B CD1 1 
ATOM   3941 C CD2 . LEU B 2 285 ? 209.287 234.141 332.698 1.00 46.68  ? 285 LEU B CD2 1 
ATOM   3942 N N   . SER B 2 286 ? 207.707 230.657 328.964 1.00 56.82  ? 286 SER B N   1 
ATOM   3943 C CA  . SER B 2 286 ? 207.489 229.375 328.302 1.00 50.08  ? 286 SER B CA  1 
ATOM   3944 C C   . SER B 2 286 ? 207.534 228.231 329.304 1.00 47.69  ? 286 SER B C   1 
ATOM   3945 O O   . SER B 2 286 ? 206.709 227.313 329.248 1.00 58.96  ? 286 SER B O   1 
ATOM   3946 C CB  . SER B 2 286 ? 208.530 229.167 327.205 1.00 53.16  ? 286 SER B CB  1 
ATOM   3947 O OG  . SER B 2 286 ? 208.468 230.207 326.247 1.00 56.76  ? 286 SER B OG  1 
ATOM   3948 N N   . ILE B 2 287 ? 208.492 228.267 330.224 1.00 41.43  ? 287 ILE B N   1 
ATOM   3949 C CA  . ILE B 2 287 ? 208.620 227.268 331.277 1.00 43.41  ? 287 ILE B CA  1 
ATOM   3950 C C   . ILE B 2 287 ? 208.986 227.995 332.562 1.00 41.65  ? 287 ILE B C   1 
ATOM   3951 O O   . ILE B 2 287 ? 209.772 228.947 332.541 1.00 44.26  ? 287 ILE B O   1 
ATOM   3952 C CB  . ILE B 2 287 ? 209.674 226.204 330.912 1.00 48.03  ? 287 ILE B CB  1 
ATOM   3953 C CG1 . ILE B 2 287 ? 209.451 224.928 331.721 1.00 49.43  ? 287 ILE B CG1 1 
ATOM   3954 C CG2 . ILE B 2 287 ? 211.072 226.736 331.153 1.00 51.01  ? 287 ILE B CG2 1 
ATOM   3955 C CD1 . ILE B 2 287 ? 210.362 223.793 331.318 1.00 42.29  ? 287 ILE B CD1 1 
ATOM   3956 N N   . ASP B 2 288 ? 208.413 227.555 333.680 1.00 43.51  ? 288 ASP B N   1 
ATOM   3957 C CA  . ASP B 2 288 ? 208.623 228.240 334.946 1.00 46.89  ? 288 ASP B CA  1 
ATOM   3958 C C   . ASP B 2 288 ? 208.601 227.231 336.084 1.00 42.18  ? 288 ASP B C   1 
ATOM   3959 O O   . ASP B 2 288 ? 208.055 226.133 335.960 1.00 48.20  ? 288 ASP B O   1 
ATOM   3960 C CB  . ASP B 2 288 ? 207.564 229.323 335.178 1.00 55.82  ? 288 ASP B CB  1 
ATOM   3961 C CG  . ASP B 2 288 ? 207.802 230.113 336.452 1.00 62.43  ? 288 ASP B CG  1 
ATOM   3962 O OD1 . ASP B 2 288 ? 208.808 229.846 337.139 1.00 64.18  ? 288 ASP B OD1 1 
ATOM   3963 O OD2 . ASP B 2 288 ? 206.982 230.999 336.769 1.00 58.52  ? 288 ASP B OD2 1 
ATOM   3964 N N   . SER B 2 289 ? 209.203 227.630 337.202 1.00 45.44  ? 289 SER B N   1 
ATOM   3965 C CA  . SER B 2 289 ? 209.258 226.776 338.380 1.00 50.50  ? 289 SER B CA  1 
ATOM   3966 C C   . SER B 2 289 ? 207.856 226.393 338.830 1.00 52.88  ? 289 SER B C   1 
ATOM   3967 O O   . SER B 2 289 ? 206.969 227.244 338.935 1.00 53.79  ? 289 SER B O   1 
ATOM   3968 C CB  . SER B 2 289 ? 209.994 227.497 339.507 1.00 44.08  ? 289 SER B CB  1 
ATOM   3969 O OG  . SER B 2 289 ? 209.904 226.769 340.717 1.00 49.84  ? 289 SER B OG  1 
ATOM   3970 N N   . MET B 2 290 ? 207.658 225.104 339.105 1.00 50.97  ? 290 MET B N   1 
ATOM   3971 C CA  . MET B 2 290 ? 206.366 224.610 339.557 1.00 44.43  ? 290 MET B CA  1 
ATOM   3972 C C   . MET B 2 290 ? 206.184 224.700 341.063 1.00 45.57  ? 290 MET B C   1 
ATOM   3973 O O   . MET B 2 290 ? 205.042 224.700 341.535 1.00 44.76  ? 290 MET B O   1 
ATOM   3974 C CB  . MET B 2 290 ? 206.171 223.154 339.126 1.00 51.34  ? 290 MET B CB  1 
ATOM   3975 C CG  . MET B 2 290 ? 205.611 222.989 337.727 1.00 48.73  ? 290 MET B CG  1 
ATOM   3976 S SD  . MET B 2 290 ? 205.120 221.288 337.389 1.00 68.29  ? 290 MET B SD  1 
ATOM   3977 C CE  . MET B 2 290 ? 204.285 221.481 335.819 1.00 57.88  ? 290 MET B CE  1 
ATOM   3978 N N   . VAL B 2 291 ? 207.274 224.769 341.829 1.00 45.63  ? 291 VAL B N   1 
ATOM   3979 C CA  . VAL B 2 291 ? 207.149 224.852 343.279 1.00 43.79  ? 291 VAL B CA  1 
ATOM   3980 C C   . VAL B 2 291 ? 206.845 226.269 343.741 1.00 50.38  ? 291 VAL B C   1 
ATOM   3981 O O   . VAL B 2 291 ? 206.304 226.450 344.838 1.00 58.85  ? 291 VAL B O   1 
ATOM   3982 C CB  . VAL B 2 291 ? 208.427 224.339 343.962 1.00 44.85  ? 291 VAL B CB  1 
ATOM   3983 C CG1 . VAL B 2 291 ? 208.227 224.250 345.464 1.00 45.51  ? 291 VAL B CG1 1 
ATOM   3984 C CG2 . VAL B 2 291 ? 208.822 222.987 343.399 1.00 55.93  ? 291 VAL B CG2 1 
ATOM   3985 N N   . LYS B 2 292 ? 207.174 227.279 342.937 1.00 52.71  ? 292 LYS B N   1 
ATOM   3986 C CA  . LYS B 2 292 ? 206.894 228.669 343.284 1.00 47.59  ? 292 LYS B CA  1 
ATOM   3987 C C   . LYS B 2 292 ? 205.578 229.143 342.677 1.00 46.72  ? 292 LYS B C   1 
ATOM   3988 O O   . LYS B 2 292 ? 204.674 229.578 343.397 1.00 49.99  ? 292 LYS B O   1 
ATOM   3989 C CB  . LYS B 2 292 ? 208.039 229.570 342.812 1.00 49.19  ? 292 LYS B CB  1 
ATOM   3990 C CG  . LYS B 2 292 ? 209.347 229.365 343.544 1.00 47.80  ? 292 LYS B CG  1 
ATOM   3991 C CD  . LYS B 2 292 ? 210.452 230.200 342.921 1.00 53.38  ? 292 LYS B CD  1 
ATOM   3992 C CE  . LYS B 2 292 ? 211.787 229.954 343.598 1.00 60.03  ? 292 LYS B CE  1 
ATOM   3993 N NZ  . LYS B 2 292 ? 212.884 230.739 342.969 1.00 56.91  ? 292 LYS B NZ  1 
ATOM   3994 N N   . HIS B 2 293 ? 205.458 229.060 341.357 1.00 42.84  ? 293 HIS B N   1 
ATOM   3995 C CA  . HIS B 2 293 ? 204.351 229.658 340.625 1.00 48.12  ? 293 HIS B CA  1 
ATOM   3996 C C   . HIS B 2 293 ? 203.275 228.610 340.367 1.00 51.07  ? 293 HIS B C   1 
ATOM   3997 O O   . HIS B 2 293 ? 203.555 227.558 339.782 1.00 53.01  ? 293 HIS B O   1 
ATOM   3998 C CB  . HIS B 2 293 ? 204.843 230.249 339.305 1.00 44.37  ? 293 HIS B CB  1 
ATOM   3999 C CG  . HIS B 2 293 ? 203.800 231.027 338.568 1.00 52.38  ? 293 HIS B CG  1 
ATOM   4000 N ND1 . HIS B 2 293 ? 203.683 231.000 337.195 1.00 55.83  ? 293 HIS B ND1 1 
ATOM   4001 C CD2 . HIS B 2 293 ? 202.829 231.858 339.012 1.00 53.53  ? 293 HIS B CD2 1 
ATOM   4002 C CE1 . HIS B 2 293 ? 202.681 231.778 336.827 1.00 52.42  ? 293 HIS B CE1 1 
ATOM   4003 N NE2 . HIS B 2 293 ? 202.147 232.310 337.911 1.00 51.36  ? 293 HIS B NE2 1 
ATOM   4004 N N   . ASN B 2 294 ? 202.049 228.904 340.797 1.00 47.08  ? 294 ASN B N   1 
ATOM   4005 C CA  . ASN B 2 294 ? 200.886 228.067 340.525 1.00 40.85  ? 294 ASN B CA  1 
ATOM   4006 C C   . ASN B 2 294 ? 200.131 228.681 339.352 1.00 42.64  ? 294 ASN B C   1 
ATOM   4007 O O   . ASN B 2 294 ? 199.452 229.700 339.509 1.00 42.31  ? 294 ASN B O   1 
ATOM   4008 C CB  . ASN B 2 294 ? 199.996 227.954 341.758 1.00 41.80  ? 294 ASN B CB  1 
ATOM   4009 C CG  . ASN B 2 294 ? 200.730 227.387 342.951 1.00 47.48  ? 294 ASN B CG  1 
ATOM   4010 O OD1 . ASN B 2 294 ? 201.613 226.544 342.807 1.00 45.55  ? 294 ASN B OD1 1 
ATOM   4011 N ND2 . ASN B 2 294 ? 200.373 227.850 344.141 1.00 49.51  ? 294 ASN B ND2 1 
ATOM   4012 N N   . ASN B 2 295 ? 200.242 228.052 338.182 1.00 54.01  ? 295 ASN B N   1 
ATOM   4013 C CA  . ASN B 2 295 ? 199.729 228.657 336.957 1.00 50.84  ? 295 ASN B CA  1 
ATOM   4014 C C   . ASN B 2 295 ? 198.222 228.870 337.035 1.00 48.96  ? 295 ASN B C   1 
ATOM   4015 O O   . ASN B 2 295 ? 197.739 230.006 336.998 1.00 52.89  ? 295 ASN B O   1 
ATOM   4016 C CB  . ASN B 2 295 ? 200.086 227.781 335.756 1.00 55.23  ? 295 ASN B CB  1 
ATOM   4017 C CG  . ASN B 2 295 ? 201.532 227.339 335.767 1.00 62.32  ? 295 ASN B CG  1 
ATOM   4018 O OD1 . ASN B 2 295 ? 201.837 226.167 335.550 1.00 57.08  ? 295 ASN B OD1 1 
ATOM   4019 N ND2 . ASN B 2 295 ? 202.434 228.275 336.029 1.00 63.04  ? 295 ASN B ND2 1 
ATOM   4020 N N   . TRP B 2 296 ? 197.464 227.786 337.141 1.00 42.99  ? 296 TRP B N   1 
ATOM   4021 C CA  . TRP B 2 296 ? 196.014 227.840 337.120 1.00 36.09  ? 296 TRP B CA  1 
ATOM   4022 C C   . TRP B 2 296 ? 195.461 227.815 338.541 1.00 34.66  ? 296 TRP B C   1 
ATOM   4023 O O   . TRP B 2 296 ? 196.200 227.850 339.527 1.00 43.78  ? 296 TRP B O   1 
ATOM   4024 C CB  . TRP B 2 296 ? 195.457 226.677 336.298 1.00 28.07  ? 296 TRP B CB  1 
ATOM   4025 C CG  . TRP B 2 296 ? 195.678 226.813 334.834 1.00 36.30  ? 296 TRP B CG  1 
ATOM   4026 C CD1 . TRP B 2 296 ? 196.710 226.299 334.111 1.00 37.86  ? 296 TRP B CD1 1 
ATOM   4027 C CD2 . TRP B 2 296 ? 194.844 227.508 333.906 1.00 34.42  ? 296 TRP B CD2 1 
ATOM   4028 N NE1 . TRP B 2 296 ? 196.572 226.632 332.789 1.00 36.85  ? 296 TRP B NE1 1 
ATOM   4029 C CE2 . TRP B 2 296 ? 195.432 227.376 332.637 1.00 38.15  ? 296 TRP B CE2 1 
ATOM   4030 C CE3 . TRP B 2 296 ? 193.656 228.231 334.025 1.00 35.52  ? 296 TRP B CE3 1 
ATOM   4031 C CZ2 . TRP B 2 296 ? 194.875 227.939 331.495 1.00 36.76  ? 296 TRP B CZ2 1 
ATOM   4032 C CZ3 . TRP B 2 296 ? 193.104 228.789 332.892 1.00 38.86  ? 296 TRP B CZ3 1 
ATOM   4033 C CH2 . TRP B 2 296 ? 193.713 228.640 331.643 1.00 38.74  ? 296 TRP B CH2 1 
ATOM   4034 N N   . GLY B 2 297 ? 194.139 227.761 338.644 1.00 40.39  ? 297 GLY B N   1 
ATOM   4035 C CA  . GLY B 2 297 ? 193.470 227.540 339.907 1.00 46.85  ? 297 GLY B CA  1 
ATOM   4036 C C   . GLY B 2 297 ? 192.010 227.213 339.683 1.00 51.97  ? 297 GLY B C   1 
ATOM   4037 O O   . GLY B 2 297 ? 191.312 227.936 338.967 1.00 62.61  ? 297 GLY B O   1 
ATOM   4038 N N   . ILE B 2 298 ? 191.534 226.132 340.285 1.00 39.56  ? 298 ILE B N   1 
ATOM   4039 C CA  . ILE B 2 298 ? 190.154 225.695 340.133 1.00 37.52  ? 298 ILE B CA  1 
ATOM   4040 C C   . ILE B 2 298 ? 189.353 226.229 341.308 1.00 44.51  ? 298 ILE B C   1 
ATOM   4041 O O   . ILE B 2 298 ? 189.738 226.043 342.467 1.00 45.71  ? 298 ILE B O   1 
ATOM   4042 C CB  . ILE B 2 298 ? 190.071 224.163 340.062 1.00 42.37  ? 298 ILE B CB  1 
ATOM   4043 C CG1 . ILE B 2 298 ? 190.761 223.647 338.800 1.00 44.86  ? 298 ILE B CG1 1 
ATOM   4044 C CG2 . ILE B 2 298 ? 188.624 223.705 340.113 1.00 45.68  ? 298 ILE B CG2 1 
ATOM   4045 C CD1 . ILE B 2 298 ? 190.049 224.000 337.516 1.00 45.97  ? 298 ILE B CD1 1 
ATOM   4046 N N   . ALA B 2 299 ? 188.241 226.899 341.012 1.00 39.78  ? 299 ALA B N   1 
ATOM   4047 C CA  . ALA B 2 299 ? 187.333 227.408 342.030 1.00 36.63  ? 299 ALA B CA  1 
ATOM   4048 C C   . ALA B 2 299 ? 185.945 226.860 341.746 1.00 48.36  ? 299 ALA B C   1 
ATOM   4049 O O   . ALA B 2 299 ? 185.394 227.095 340.666 1.00 51.30  ? 299 ALA B O   1 
ATOM   4050 C CB  . ALA B 2 299 ? 187.317 228.938 342.047 1.00 37.23  ? 299 ALA B CB  1 
ATOM   4051 N N   . ILE B 2 300 ? 185.390 226.133 342.707 1.00 51.31  ? 300 ILE B N   1 
ATOM   4052 C CA  . ILE B 2 300 ? 184.060 225.549 342.603 1.00 41.09  ? 300 ILE B CA  1 
ATOM   4053 C C   . ILE B 2 300 ? 183.167 226.289 343.586 1.00 47.36  ? 300 ILE B C   1 
ATOM   4054 O O   . ILE B 2 300 ? 183.360 226.191 344.804 1.00 52.39  ? 300 ILE B O   1 
ATOM   4055 C CB  . ILE B 2 300 ? 184.075 224.044 342.896 1.00 42.72  ? 300 ILE B CB  1 
ATOM   4056 C CG1 . ILE B 2 300 ? 184.918 223.314 341.850 1.00 50.30  ? 300 ILE B CG1 1 
ATOM   4057 C CG2 . ILE B 2 300 ? 182.655 223.500 342.939 1.00 46.90  ? 300 ILE B CG2 1 
ATOM   4058 C CD1 . ILE B 2 300 ? 185.060 221.830 342.100 1.00 50.29  ? 300 ILE B CD1 1 
ATOM   4059 N N   . LEU B 2 301 ? 182.188 227.025 343.067 1.00 44.42  ? 301 LEU B N   1 
ATOM   4060 C CA  . LEU B 2 301 ? 181.270 227.776 343.906 1.00 39.47  ? 301 LEU B CA  1 
ATOM   4061 C C   . LEU B 2 301 ? 179.835 227.368 343.598 1.00 47.32  ? 301 LEU B C   1 
ATOM   4062 O O   . LEU B 2 301 ? 179.467 227.284 342.421 1.00 50.19  ? 301 LEU B O   1 
ATOM   4063 C CB  . LEU B 2 301 ? 181.432 229.286 343.691 1.00 42.46  ? 301 LEU B CB  1 
ATOM   4064 C CG  . LEU B 2 301 ? 182.817 229.868 343.969 1.00 49.07  ? 301 LEU B CG  1 
ATOM   4065 C CD1 . LEU B 2 301 ? 183.628 229.947 342.691 1.00 53.20  ? 301 LEU B CD1 1 
ATOM   4066 C CD2 . LEU B 2 301 ? 182.699 231.235 344.613 1.00 50.49  ? 301 LEU B CD2 1 
ATOM   4067 N N   . PRO B 2 302 ? 178.992 227.126 344.602 1.00 50.24  ? 302 PRO B N   1 
ATOM   4068 C CA  . PRO B 2 302 ? 177.603 226.744 344.319 1.00 47.14  ? 302 PRO B CA  1 
ATOM   4069 C C   . PRO B 2 302 ? 176.759 227.961 343.975 1.00 45.67  ? 302 PRO B C   1 
ATOM   4070 O O   . PRO B 2 302 ? 176.451 228.790 344.838 1.00 44.89  ? 302 PRO B O   1 
ATOM   4071 C CB  . PRO B 2 302 ? 177.154 226.078 345.627 1.00 45.18  ? 302 PRO B CB  1 
ATOM   4072 C CG  . PRO B 2 302 ? 178.069 226.604 346.688 1.00 51.88  ? 302 PRO B CG  1 
ATOM   4073 C CD  . PRO B 2 302 ? 179.210 227.337 346.042 1.00 49.72  ? 302 PRO B CD  1 
ATOM   4074 N N   . LEU B 2 303 ? 176.380 228.070 342.700 1.00 40.33  ? 303 LEU B N   1 
ATOM   4075 C CA  . LEU B 2 303 ? 175.574 229.203 342.260 1.00 36.84  ? 303 LEU B CA  1 
ATOM   4076 C C   . LEU B 2 303 ? 174.206 229.194 342.927 1.00 47.09  ? 303 LEU B C   1 
ATOM   4077 O O   . LEU B 2 303 ? 173.713 230.239 343.365 1.00 41.65  ? 303 LEU B O   1 
ATOM   4078 C CB  . LEU B 2 303 ? 175.425 229.176 340.740 1.00 36.85  ? 303 LEU B CB  1 
ATOM   4079 C CG  . LEU B 2 303 ? 176.718 229.021 339.939 1.00 33.20  ? 303 LEU B CG  1 
ATOM   4080 C CD1 . LEU B 2 303 ? 176.417 228.943 338.456 1.00 31.44  ? 303 LEU B CD1 1 
ATOM   4081 C CD2 . LEU B 2 303 ? 177.665 230.164 340.227 1.00 38.50  ? 303 LEU B CD2 1 
ATOM   4082 N N   . ALA B 2 304 ? 173.577 228.023 343.010 1.00 54.86  ? 304 ALA B N   1 
ATOM   4083 C CA  . ALA B 2 304 ? 172.303 227.848 343.682 1.00 50.98  ? 304 ALA B CA  1 
ATOM   4084 C C   . ALA B 2 304 ? 172.451 226.792 344.769 1.00 50.83  ? 304 ALA B C   1 
ATOM   4085 O O   . ALA B 2 304 ? 173.044 225.734 344.517 1.00 56.19  ? 304 ALA B O   1 
ATOM   4086 C CB  . ALA B 2 304 ? 171.209 227.430 342.691 1.00 48.83  ? 304 ALA B CB  1 
ATOM   4087 N N   . PRO B 2 305 ? 171.935 227.025 345.972 1.00 51.17  ? 305 PRO B N   1 
ATOM   4088 C CA  . PRO B 2 305 ? 172.211 226.104 347.077 1.00 55.06  ? 305 PRO B CA  1 
ATOM   4089 C C   . PRO B 2 305 ? 171.553 224.752 346.866 1.00 60.90  ? 305 PRO B C   1 
ATOM   4090 O O   . PRO B 2 305 ? 170.540 224.624 346.177 1.00 68.95  ? 305 PRO B O   1 
ATOM   4091 C CB  . PRO B 2 305 ? 171.622 226.826 348.292 1.00 54.76  ? 305 PRO B CB  1 
ATOM   4092 C CG  . PRO B 2 305 ? 170.501 227.617 347.729 1.00 58.06  ? 305 PRO B CG  1 
ATOM   4093 C CD  . PRO B 2 305 ? 170.925 228.032 346.342 1.00 53.76  ? 305 PRO B CD  1 
ATOM   4094 N N   . LEU B 2 306 ? 172.148 223.732 347.476 1.00 58.59  ? 306 LEU B N   1 
ATOM   4095 C CA  . LEU B 2 306 ? 171.588 222.391 347.399 1.00 58.82  ? 306 LEU B CA  1 
ATOM   4096 C C   . LEU B 2 306 ? 170.257 222.334 348.136 1.00 60.77  ? 306 LEU B C   1 
ATOM   4097 O O   . LEU B 2 306 ? 170.070 222.985 349.166 1.00 67.71  ? 306 LEU B O   1 
ATOM   4098 C CB  . LEU B 2 306 ? 172.559 221.375 347.995 1.00 58.26  ? 306 LEU B CB  1 
ATOM   4099 C CG  . LEU B 2 306 ? 172.218 219.906 347.753 1.00 56.15  ? 306 LEU B CG  1 
ATOM   4100 C CD1 . LEU B 2 306 ? 172.467 219.526 346.304 1.00 57.31  ? 306 LEU B CD1 1 
ATOM   4101 C CD2 . LEU B 2 306 ? 173.018 219.020 348.684 1.00 62.99  ? 306 LEU B CD2 1 
ATOM   4102 N N   . ASN B 2 307 ? 169.329 221.548 347.600 1.00 68.13  ? 307 ASN B N   1 
ATOM   4103 C CA  . ASN B 2 307 ? 168.031 221.355 348.227 1.00 73.13  ? 307 ASN B CA  1 
ATOM   4104 C C   . ASN B 2 307 ? 167.480 220.006 347.795 1.00 71.15  ? 307 ASN B C   1 
ATOM   4105 O O   . ASN B 2 307 ? 167.726 219.552 346.675 1.00 70.61  ? 307 ASN B O   1 
ATOM   4106 C CB  . ASN B 2 307 ? 167.057 222.479 347.859 1.00 71.95  ? 307 ASN B CB  1 
ATOM   4107 C CG  . ASN B 2 307 ? 166.670 223.326 349.052 1.00 74.34  ? 307 ASN B CG  1 
ATOM   4108 O OD1 . ASN B 2 307 ? 166.493 222.816 350.158 1.00 74.33  ? 307 ASN B OD1 1 
ATOM   4109 N ND2 . ASN B 2 307 ? 166.539 224.629 348.834 1.00 70.28  ? 307 ASN B ND2 1 
ATOM   4110 N N   . PHE B 2 308 ? 166.732 219.368 348.693 1.00 72.26  ? 308 PHE B N   1 
ATOM   4111 C CA  . PHE B 2 308 ? 166.242 218.018 348.429 1.00 80.01  ? 308 PHE B CA  1 
ATOM   4112 C C   . PHE B 2 308 ? 165.062 217.709 349.336 1.00 85.04  ? 308 PHE B C   1 
ATOM   4113 O O   . PHE B 2 308 ? 165.219 217.660 350.560 1.00 87.46  ? 308 PHE B O   1 
ATOM   4114 C CB  . PHE B 2 308 ? 167.359 216.999 348.633 1.00 77.69  ? 308 PHE B CB  1 
ATOM   4115 C CG  . PHE B 2 308 ? 166.886 215.577 348.648 1.00 75.74  ? 308 PHE B CG  1 
ATOM   4116 C CD1 . PHE B 2 308 ? 166.372 214.994 347.507 1.00 73.19  ? 308 PHE B CD1 1 
ATOM   4117 C CD2 . PHE B 2 308 ? 166.962 214.822 349.804 1.00 75.26  ? 308 PHE B CD2 1 
ATOM   4118 C CE1 . PHE B 2 308 ? 165.937 213.688 347.519 1.00 78.80  ? 308 PHE B CE1 1 
ATOM   4119 C CE2 . PHE B 2 308 ? 166.530 213.514 349.821 1.00 76.30  ? 308 PHE B CE2 1 
ATOM   4120 C CZ  . PHE B 2 308 ? 166.016 212.947 348.677 1.00 79.94  ? 308 PHE B CZ  1 
ATOM   4121 N N   . ALA B 2 309 ? 163.892 217.501 348.734 1.00 89.34  ? 309 ALA B N   1 
ATOM   4122 C CA  . ALA B 2 309 ? 162.714 216.974 349.421 1.00 88.38  ? 309 ALA B CA  1 
ATOM   4123 C C   . ALA B 2 309 ? 162.458 217.698 350.739 1.00 89.40  ? 309 ALA B C   1 
ATOM   4124 O O   . ALA B 2 309 ? 162.194 217.085 351.775 1.00 87.30  ? 309 ALA B O   1 
ATOM   4125 C CB  . ALA B 2 309 ? 162.854 215.469 349.650 1.00 88.12  ? 309 ALA B CB  1 
ATOM   4126 N N   . SER B 2 310 ? 162.540 219.026 350.695 1.00 109.51 ? 310 SER B N   1 
ATOM   4127 C CA  . SER B 2 310 ? 162.293 219.864 351.868 1.00 110.69 ? 310 SER B CA  1 
ATOM   4128 C C   . SER B 2 310 ? 163.155 219.448 353.055 1.00 109.11 ? 310 SER B C   1 
ATOM   4129 O O   . SER B 2 310 ? 162.828 219.754 354.206 1.00 108.81 ? 310 SER B O   1 
ATOM   4130 C CB  . SER B 2 310 ? 160.812 219.839 352.261 1.00 109.02 ? 310 SER B CB  1 
ATOM   4131 O OG  . SER B 2 310 ? 160.593 220.545 353.470 1.00 109.21 ? 310 SER B OG  1 
ATOM   4132 N N   . GLU B 2 311 ? 164.257 218.752 352.794 1.00 99.99  ? 311 GLU B N   1 
ATOM   4133 C CA  . GLU B 2 311 ? 165.139 218.274 353.848 1.00 100.00 ? 311 GLU B CA  1 
ATOM   4134 C C   . GLU B 2 311 ? 166.241 219.299 354.078 1.00 100.91 ? 311 GLU B C   1 
ATOM   4135 O O   . GLU B 2 311 ? 166.885 219.752 353.127 1.00 99.54  ? 311 GLU B O   1 
ATOM   4136 C CB  . GLU B 2 311 ? 165.732 216.915 353.475 1.00 98.29  ? 311 GLU B CB  1 
ATOM   4137 C CG  . GLU B 2 311 ? 166.434 216.207 354.619 1.00 98.31  ? 311 GLU B CG  1 
ATOM   4138 C CD  . GLU B 2 311 ? 166.926 214.829 354.231 1.00 98.32  ? 311 GLU B CD  1 
ATOM   4139 O OE1 . GLU B 2 311 ? 166.685 214.413 353.079 1.00 98.06  ? 311 GLU B OE1 1 
ATOM   4140 O OE2 . GLU B 2 311 ? 167.555 214.160 355.079 1.00 97.81  ? 311 GLU B OE2 1 
ATOM   4141 N N   . SER B 2 312 ? 166.453 219.661 355.340 1.00 103.94 ? 312 SER B N   1 
ATOM   4142 C CA  . SER B 2 312 ? 167.368 220.737 355.697 1.00 103.77 ? 312 SER B CA  1 
ATOM   4143 C C   . SER B 2 312 ? 168.803 220.267 355.892 1.00 101.59 ? 312 SER B C   1 
ATOM   4144 O O   . SER B 2 312 ? 169.666 221.089 356.218 1.00 102.16 ? 312 SER B O   1 
ATOM   4145 C CB  . SER B 2 312 ? 166.884 221.434 356.972 1.00 102.89 ? 312 SER B CB  1 
ATOM   4146 O OG  . SER B 2 312 ? 165.584 221.969 356.799 1.00 99.93  ? 312 SER B OG  1 
ATOM   4147 N N   . SER B 2 313 ? 169.084 218.980 355.703 1.00 90.04  ? 313 SER B N   1 
ATOM   4148 C CA  . SER B 2 313 ? 170.445 218.448 355.797 1.00 91.54  ? 313 SER B CA  1 
ATOM   4149 C C   . SER B 2 313 ? 170.745 217.551 354.602 1.00 88.60  ? 313 SER B C   1 
ATOM   4150 O O   . SER B 2 313 ? 170.990 216.352 354.755 1.00 90.27  ? 313 SER B O   1 
ATOM   4151 C CB  . SER B 2 313 ? 170.630 217.684 357.106 1.00 91.80  ? 313 SER B CB  1 
ATOM   4152 O OG  . SER B 2 313 ? 170.279 218.483 358.222 1.00 91.97  ? 313 SER B OG  1 
ATOM   4153 N N   . PRO B 2 314 ? 170.737 218.104 353.383 1.00 80.26  ? 314 PRO B N   1 
ATOM   4154 C CA  . PRO B 2 314 ? 171.152 217.307 352.226 1.00 78.76  ? 314 PRO B CA  1 
ATOM   4155 C C   . PRO B 2 314 ? 172.633 217.463 351.930 1.00 77.18  ? 314 PRO B C   1 
ATOM   4156 O O   . PRO B 2 314 ? 173.142 218.586 351.865 1.00 82.68  ? 314 PRO B O   1 
ATOM   4157 C CB  . PRO B 2 314 ? 170.284 217.866 351.096 1.00 81.31  ? 314 PRO B CB  1 
ATOM   4158 C CG  . PRO B 2 314 ? 170.001 219.296 351.501 1.00 82.85  ? 314 PRO B CG  1 
ATOM   4159 C CD  . PRO B 2 314 ? 170.345 219.461 352.969 1.00 81.50  ? 314 PRO B CD  1 
ATOM   4160 N N   . GLU B 2 315 ? 173.332 216.347 351.753 1.00 61.33  ? 315 GLU B N   1 
ATOM   4161 C CA  . GLU B 2 315 ? 174.745 216.350 351.414 1.00 59.84  ? 315 GLU B CA  1 
ATOM   4162 C C   . GLU B 2 315 ? 174.953 215.516 350.164 1.00 63.29  ? 315 GLU B C   1 
ATOM   4163 O O   . GLU B 2 315 ? 174.331 214.464 350.004 1.00 72.11  ? 315 GLU B O   1 
ATOM   4164 C CB  . GLU B 2 315 ? 175.606 215.793 352.558 1.00 60.23  ? 315 GLU B CB  1 
ATOM   4165 C CG  . GLU B 2 315 ? 177.082 215.621 352.200 1.00 65.08  ? 315 GLU B CG  1 
ATOM   4166 C CD  . GLU B 2 315 ? 177.373 214.329 351.452 1.00 66.20  ? 315 GLU B CD  1 
ATOM   4167 O OE1 . GLU B 2 315 ? 176.501 213.436 351.435 1.00 66.48  ? 315 GLU B OE1 1 
ATOM   4168 O OE2 . GLU B 2 315 ? 178.474 214.208 350.874 1.00 60.24  ? 315 GLU B OE2 1 
ATOM   4169 N N   . ILE B 2 316 ? 175.813 215.995 349.274 1.00 51.03  ? 316 ILE B N   1 
ATOM   4170 C CA  . ILE B 2 316 ? 176.310 215.164 348.182 1.00 53.46  ? 316 ILE B CA  1 
ATOM   4171 C C   . ILE B 2 316 ? 177.803 215.427 348.033 1.00 59.50  ? 316 ILE B C   1 
ATOM   4172 O O   . ILE B 2 316 ? 178.257 216.553 348.279 1.00 64.78  ? 316 ILE B O   1 
ATOM   4173 C CB  . ILE B 2 316 ? 175.550 215.429 346.874 1.00 44.50  ? 316 ILE B CB  1 
ATOM   4174 C CG1 . ILE B 2 316 ? 175.789 216.854 346.383 1.00 50.97  ? 316 ILE B CG1 1 
ATOM   4175 C CG2 . ILE B 2 316 ? 174.070 215.191 347.080 1.00 49.43  ? 316 ILE B CG2 1 
ATOM   4176 C CD1 . ILE B 2 316 ? 175.037 217.176 345.119 1.00 58.39  ? 316 ILE B CD1 1 
ATOM   4177 N N   . PRO B 2 317 ? 178.601 214.436 347.645 1.00 53.34  ? 317 PRO B N   1 
ATOM   4178 C CA  . PRO B 2 317 ? 180.043 214.652 347.522 1.00 51.07  ? 317 PRO B CA  1 
ATOM   4179 C C   . PRO B 2 317 ? 180.465 215.089 346.130 1.00 53.44  ? 317 PRO B C   1 
ATOM   4180 O O   . PRO B 2 317 ? 179.890 214.692 345.115 1.00 51.35  ? 317 PRO B O   1 
ATOM   4181 C CB  . PRO B 2 317 ? 180.622 213.272 347.862 1.00 56.21  ? 317 PRO B CB  1 
ATOM   4182 C CG  . PRO B 2 317 ? 179.555 212.304 347.519 1.00 59.36  ? 317 PRO B CG  1 
ATOM   4183 C CD  . PRO B 2 317 ? 178.239 213.017 347.491 1.00 47.67  ? 317 PRO B CD  1 
ATOM   4184 N N   . ILE B 2 318 ? 181.500 215.926 346.102 1.00 56.67  ? 318 ILE B N   1 
ATOM   4185 C CA  . ILE B 2 318 ? 182.090 216.434 344.869 1.00 53.28  ? 318 ILE B CA  1 
ATOM   4186 C C   . ILE B 2 318 ? 183.526 215.941 344.803 1.00 50.37  ? 318 ILE B C   1 
ATOM   4187 O O   . ILE B 2 318 ? 184.271 216.058 345.782 1.00 52.06  ? 318 ILE B O   1 
ATOM   4188 C CB  . ILE B 2 318 ? 182.050 217.972 344.801 1.00 48.42  ? 318 ILE B CB  1 
ATOM   4189 C CG1 . ILE B 2 318 ? 180.648 218.492 345.119 1.00 47.08  ? 318 ILE B CG1 1 
ATOM   4190 C CG2 . ILE B 2 318 ? 182.484 218.450 343.421 1.00 48.97  ? 318 ILE B CG2 1 
ATOM   4191 C CD1 . ILE B 2 318 ? 180.584 219.994 345.267 1.00 53.50  ? 318 ILE B CD1 1 
ATOM   4192 N N   . THR B 2 319 ? 183.916 215.401 343.652 1.00 53.00  ? 319 THR B N   1 
ATOM   4193 C CA  . THR B 2 319 ? 185.256 214.868 343.465 1.00 59.40  ? 319 THR B CA  1 
ATOM   4194 C C   . THR B 2 319 ? 185.923 215.558 342.286 1.00 64.03  ? 319 THR B C   1 
ATOM   4195 O O   . THR B 2 319 ? 185.261 215.984 341.338 1.00 71.74  ? 319 THR B O   1 
ATOM   4196 C CB  . THR B 2 319 ? 185.232 213.351 343.232 1.00 52.08  ? 319 THR B CB  1 
ATOM   4197 O OG1 . THR B 2 319 ? 184.656 212.699 344.369 1.00 59.65  ? 319 THR B OG1 1 
ATOM   4198 C CG2 . THR B 2 319 ? 186.637 212.820 343.010 1.00 52.48  ? 319 THR B CG2 1 
ATOM   4199 N N   . LEU B 2 320 ? 187.244 215.683 342.363 1.00 48.51  ? 320 LEU B N   1 
ATOM   4200 C CA  . LEU B 2 320 ? 188.049 216.216 341.276 1.00 44.63  ? 320 LEU B CA  1 
ATOM   4201 C C   . LEU B 2 320 ? 189.001 215.140 340.782 1.00 54.19  ? 320 LEU B C   1 
ATOM   4202 O O   . LEU B 2 320 ? 189.541 214.364 341.575 1.00 64.80  ? 320 LEU B O   1 
ATOM   4203 C CB  . LEU B 2 320 ? 188.850 217.442 341.711 1.00 42.70  ? 320 LEU B CB  1 
ATOM   4204 C CG  . LEU B 2 320 ? 188.067 218.748 341.782 1.00 52.05  ? 320 LEU B CG  1 
ATOM   4205 C CD1 . LEU B 2 320 ? 187.315 218.848 343.094 1.00 55.87  ? 320 LEU B CD1 1 
ATOM   4206 C CD2 . LEU B 2 320 ? 189.000 219.929 341.597 1.00 50.09  ? 320 LEU B CD2 1 
ATOM   4207 N N   . THR B 2 321 ? 189.203 215.100 339.470 1.00 46.38  ? 321 THR B N   1 
ATOM   4208 C CA  . THR B 2 321 ? 190.143 214.177 338.847 1.00 36.20  ? 321 THR B CA  1 
ATOM   4209 C C   . THR B 2 321 ? 190.969 214.980 337.856 1.00 40.27  ? 321 THR B C   1 
ATOM   4210 O O   . THR B 2 321 ? 190.465 215.380 336.804 1.00 46.98  ? 321 THR B O   1 
ATOM   4211 C CB  . THR B 2 321 ? 189.413 213.027 338.158 1.00 45.98  ? 321 THR B CB  1 
ATOM   4212 O OG1 . THR B 2 321 ? 188.429 212.487 339.047 1.00 55.60  ? 321 THR B OG1 1 
ATOM   4213 C CG2 . THR B 2 321 ? 190.382 211.934 337.784 1.00 49.48  ? 321 THR B CG2 1 
ATOM   4214 N N   . ILE B 2 322 ? 192.228 215.229 338.195 1.00 47.68  ? 322 ILE B N   1 
ATOM   4215 C CA  . ILE B 2 322 ? 193.098 216.106 337.420 1.00 44.15  ? 322 ILE B CA  1 
ATOM   4216 C C   . ILE B 2 322 ? 194.148 215.251 336.732 1.00 37.88  ? 322 ILE B C   1 
ATOM   4217 O O   . ILE B 2 322 ? 194.744 214.367 337.356 1.00 42.89  ? 322 ILE B O   1 
ATOM   4218 C CB  . ILE B 2 322 ? 193.749 217.178 338.308 1.00 42.33  ? 322 ILE B CB  1 
ATOM   4219 C CG1 . ILE B 2 322 ? 192.677 217.910 339.118 1.00 50.52  ? 322 ILE B CG1 1 
ATOM   4220 C CG2 . ILE B 2 322 ? 194.531 218.161 337.454 1.00 43.42  ? 322 ILE B CG2 1 
ATOM   4221 C CD1 . ILE B 2 322 ? 193.222 218.905 340.106 1.00 44.51  ? 322 ILE B CD1 1 
ATOM   4222 N N   . ALA B 2 323 ? 194.354 215.495 335.444 1.00 39.78  ? 323 ALA B N   1 
ATOM   4223 C CA  . ALA B 2 323 ? 195.333 214.754 334.653 1.00 42.73  ? 323 ALA B CA  1 
ATOM   4224 C C   . ALA B 2 323 ? 196.295 215.722 333.988 1.00 49.01  ? 323 ALA B C   1 
ATOM   4225 O O   . ALA B 2 323 ? 195.886 216.447 333.059 1.00 59.46  ? 323 ALA B O   1 
ATOM   4226 C CB  . ALA B 2 323 ? 194.648 213.889 333.600 1.00 48.83  ? 323 ALA B CB  1 
ATOM   4227 N N   . PRO B 2 324 ? 197.553 215.788 334.417 1.00 44.46  ? 324 PRO B N   1 
ATOM   4228 C CA  . PRO B 2 324 ? 198.526 216.590 333.674 1.00 33.37  ? 324 PRO B CA  1 
ATOM   4229 C C   . PRO B 2 324 ? 198.641 216.099 332.241 1.00 41.57  ? 324 PRO B C   1 
ATOM   4230 O O   . PRO B 2 324 ? 198.597 214.899 331.969 1.00 54.77  ? 324 PRO B O   1 
ATOM   4231 C CB  . PRO B 2 324 ? 199.826 216.380 334.453 1.00 44.41  ? 324 PRO B CB  1 
ATOM   4232 C CG  . PRO B 2 324 ? 199.386 216.026 335.824 1.00 48.68  ? 324 PRO B CG  1 
ATOM   4233 C CD  . PRO B 2 324 ? 198.122 215.250 335.663 1.00 41.92  ? 324 PRO B CD  1 
ATOM   4234 N N   . MET B 2 325 ? 198.779 217.043 331.319 1.00 44.03  ? 325 MET B N   1 
ATOM   4235 C CA  . MET B 2 325 ? 198.870 216.749 329.899 1.00 45.40  ? 325 MET B CA  1 
ATOM   4236 C C   . MET B 2 325 ? 200.053 217.495 329.308 1.00 47.43  ? 325 MET B C   1 
ATOM   4237 O O   . MET B 2 325 ? 200.251 218.683 329.583 1.00 50.79  ? 325 MET B O   1 
ATOM   4238 C CB  . MET B 2 325 ? 197.590 217.146 329.162 1.00 47.57  ? 325 MET B CB  1 
ATOM   4239 C CG  . MET B 2 325 ? 196.385 216.301 329.516 1.00 56.27  ? 325 MET B CG  1 
ATOM   4240 S SD  . MET B 2 325 ? 194.907 216.787 328.609 1.00 77.51  ? 325 MET B SD  1 
ATOM   4241 C CE  . MET B 2 325 ? 195.406 216.450 326.924 1.00 58.51  ? 325 MET B CE  1 
ATOM   4242 N N   . CYS B 2 326 ? 200.832 216.790 328.492 1.00 47.91  ? 326 CYS B N   1 
ATOM   4243 C CA  . CYS B 2 326 ? 201.997 217.363 327.832 1.00 52.10  ? 326 CYS B CA  1 
ATOM   4244 C C   . CYS B 2 326 ? 202.893 218.070 328.843 1.00 49.91  ? 326 CYS B C   1 
ATOM   4245 O O   . CYS B 2 326 ? 203.316 219.211 328.651 1.00 55.03  ? 326 CYS B O   1 
ATOM   4246 C CB  . CYS B 2 326 ? 201.571 218.314 326.715 1.00 55.48  ? 326 CYS B CB  1 
ATOM   4247 S SG  . CYS B 2 326 ? 200.568 217.531 325.436 1.00 54.94  ? 326 CYS B SG  1 
ATOM   4248 N N   . CYS B 2 327 ? 203.180 217.374 329.939 1.00 48.85  ? 327 CYS B N   1 
ATOM   4249 C CA  . CYS B 2 327 ? 204.005 217.922 331.006 1.00 48.44  ? 327 CYS B CA  1 
ATOM   4250 C C   . CYS B 2 327 ? 205.476 217.677 330.696 1.00 46.86  ? 327 CYS B C   1 
ATOM   4251 O O   . CYS B 2 327 ? 205.879 216.546 330.411 1.00 49.26  ? 327 CYS B O   1 
ATOM   4252 C CB  . CYS B 2 327 ? 203.630 217.303 332.352 1.00 49.63  ? 327 CYS B CB  1 
ATOM   4253 S SG  . CYS B 2 327 ? 204.114 215.582 332.553 1.00 60.07  ? 327 CYS B SG  1 
ATOM   4254 N N   . GLU B 2 328 ? 206.266 218.745 330.745 1.00 55.95  ? 328 GLU B N   1 
ATOM   4255 C CA  . GLU B 2 328 ? 207.686 218.713 330.438 1.00 52.16  ? 328 GLU B CA  1 
ATOM   4256 C C   . GLU B 2 328 ? 208.462 219.342 331.586 1.00 44.42  ? 328 GLU B C   1 
ATOM   4257 O O   . GLU B 2 328 ? 207.963 220.236 332.274 1.00 57.86  ? 328 GLU B O   1 
ATOM   4258 C CB  . GLU B 2 328 ? 207.970 219.450 329.122 1.00 54.90  ? 328 GLU B CB  1 
ATOM   4259 C CG  . GLU B 2 328 ? 209.334 220.104 329.041 1.00 64.17  ? 328 GLU B CG  1 
ATOM   4260 C CD  . GLU B 2 328 ? 209.633 220.654 327.660 1.00 67.68  ? 328 GLU B CD  1 
ATOM   4261 O OE1 . GLU B 2 328 ? 208.782 220.497 326.760 1.00 64.58  ? 328 GLU B OE1 1 
ATOM   4262 O OE2 . GLU B 2 328 ? 210.717 221.247 327.476 1.00 61.02  ? 328 GLU B OE2 1 
ATOM   4263 N N   . PHE B 2 329 ? 209.688 218.862 331.794 1.00 35.33  ? 329 PHE B N   1 
ATOM   4264 C CA  . PHE B 2 329 ? 210.515 219.322 332.900 1.00 43.52  ? 329 PHE B CA  1 
ATOM   4265 C C   . PHE B 2 329 ? 211.947 219.536 332.429 1.00 49.98  ? 329 PHE B C   1 
ATOM   4266 O O   . PHE B 2 329 ? 212.392 218.960 331.435 1.00 52.39  ? 329 PHE B O   1 
ATOM   4267 C CB  . PHE B 2 329 ? 210.514 218.329 334.066 1.00 48.82  ? 329 PHE B CB  1 
ATOM   4268 C CG  . PHE B 2 329 ? 209.155 218.043 334.626 1.00 48.15  ? 329 PHE B CG  1 
ATOM   4269 C CD1 . PHE B 2 329 ? 208.587 218.884 335.563 1.00 49.25  ? 329 PHE B CD1 1 
ATOM   4270 C CD2 . PHE B 2 329 ? 208.453 216.922 334.230 1.00 49.50  ? 329 PHE B CD2 1 
ATOM   4271 C CE1 . PHE B 2 329 ? 207.339 218.618 336.083 1.00 50.08  ? 329 PHE B CE1 1 
ATOM   4272 C CE2 . PHE B 2 329 ? 207.205 216.652 334.749 1.00 47.54  ? 329 PHE B CE2 1 
ATOM   4273 C CZ  . PHE B 2 329 ? 206.649 217.500 335.677 1.00 47.18  ? 329 PHE B CZ  1 
ATOM   4274 N N   . ASN B 2 330 ? 212.665 220.372 333.176 1.00 50.73  ? 330 ASN B N   1 
ATOM   4275 C CA  . ASN B 2 330 ? 214.065 220.671 332.911 1.00 45.80  ? 330 ASN B CA  1 
ATOM   4276 C C   . ASN B 2 330 ? 214.751 221.011 334.225 1.00 37.58  ? 330 ASN B C   1 
ATOM   4277 O O   . ASN B 2 330 ? 214.102 221.376 335.209 1.00 43.18  ? 330 ASN B O   1 
ATOM   4278 C CB  . ASN B 2 330 ? 214.227 221.839 331.928 1.00 50.29  ? 330 ASN B CB  1 
ATOM   4279 C CG  . ASN B 2 330 ? 214.098 221.411 330.480 1.00 53.93  ? 330 ASN B CG  1 
ATOM   4280 O OD1 . ASN B 2 330 ? 214.773 220.488 330.032 1.00 55.36  ? 330 ASN B OD1 1 
ATOM   4281 N ND2 . ASN B 2 330 ? 213.225 222.084 329.740 1.00 56.95  ? 330 ASN B ND2 1 
ATOM   4282 N N   . GLY B 2 331 ? 216.079 220.912 334.223 1.00 29.35  ? 331 GLY B N   1 
ATOM   4283 C CA  . GLY B 2 331 ? 216.872 221.327 335.364 1.00 40.71  ? 331 GLY B CA  1 
ATOM   4284 C C   . GLY B 2 331 ? 216.849 220.380 336.546 1.00 39.83  ? 331 GLY B C   1 
ATOM   4285 O O   . GLY B 2 331 ? 216.335 220.735 337.609 1.00 48.08  ? 331 GLY B O   1 
ATOM   4286 N N   . LEU B 2 332 ? 217.401 219.182 336.386 1.00 35.19  ? 332 LEU B N   1 
ATOM   4287 C CA  . LEU B 2 332 ? 217.379 218.189 337.448 1.00 37.80  ? 332 LEU B CA  1 
ATOM   4288 C C   . LEU B 2 332 ? 218.470 218.472 338.479 1.00 37.03  ? 332 LEU B C   1 
ATOM   4289 O O   . LEU B 2 332 ? 219.547 218.975 338.159 1.00 35.51  ? 332 LEU B O   1 
ATOM   4290 C CB  . LEU B 2 332 ? 217.556 216.786 336.859 1.00 37.23  ? 332 LEU B CB  1 
ATOM   4291 C CG  . LEU B 2 332 ? 217.404 215.594 337.804 1.00 34.76  ? 332 LEU B CG  1 
ATOM   4292 C CD1 . LEU B 2 332 ? 216.061 215.652 338.486 1.00 44.00  ? 332 LEU B CD1 1 
ATOM   4293 C CD2 . LEU B 2 332 ? 217.558 214.289 337.052 1.00 34.69  ? 332 LEU B CD2 1 
ATOM   4294 N N   . ARG B 2 333 ? 218.172 218.134 339.733 1.00 42.80  ? 333 ARG B N   1 
ATOM   4295 C CA  . ARG B 2 333 ? 219.077 218.399 340.846 1.00 43.48  ? 333 ARG B CA  1 
ATOM   4296 C C   . ARG B 2 333 ? 218.560 217.749 342.119 1.00 43.87  ? 333 ARG B C   1 
ATOM   4297 O O   . ARG B 2 333 ? 217.570 217.012 342.089 1.00 42.12  ? 333 ARG B O   1 
ATOM   4298 C CB  . ARG B 2 333 ? 219.253 219.905 341.060 1.00 44.05  ? 333 ARG B CB  1 
ATOM   4299 C CG  . ARG B 2 333 ? 218.006 220.723 340.756 1.00 44.31  ? 333 ARG B CG  1 
ATOM   4300 C CD  . ARG B 2 333 ? 217.743 221.812 341.777 1.00 44.22  ? 333 ARG B CD  1 
ATOM   4301 N NE  . ARG B 2 333 ? 216.623 221.464 342.641 1.00 42.13  ? 333 ARG B NE  1 
ATOM   4302 C CZ  . ARG B 2 333 ? 215.368 221.384 342.223 1.00 44.12  ? 333 ARG B CZ  1 
ATOM   4303 N NH1 . ARG B 2 333 ? 215.048 221.591 340.959 1.00 43.05  ? 333 ARG B NH1 1 
ATOM   4304 N NH2 . ARG B 2 333 ? 214.412 221.076 343.092 1.00 53.63  ? 333 ARG B NH2 1 
ATOM   4305 N N   . ASN B 2 334 ? 219.226 218.017 343.240 1.00 40.30  ? 334 ASN B N   1 
ATOM   4306 C CA  . ASN B 2 334 ? 218.714 217.602 344.533 1.00 36.78  ? 334 ASN B CA  1 
ATOM   4307 C C   . ASN B 2 334 ? 217.224 217.911 344.612 1.00 42.98  ? 334 ASN B C   1 
ATOM   4308 O O   . ASN B 2 334 ? 216.714 218.824 343.958 1.00 49.86  ? 334 ASN B O   1 
ATOM   4309 C CB  . ASN B 2 334 ? 219.472 218.318 345.649 1.00 37.71  ? 334 ASN B CB  1 
ATOM   4310 C CG  . ASN B 2 334 ? 218.950 217.981 347.028 1.00 52.68  ? 334 ASN B CG  1 
ATOM   4311 O OD1 . ASN B 2 334 ? 218.077 217.127 347.189 1.00 54.92  ? 334 ASN B OD1 1 
ATOM   4312 N ND2 . ASN B 2 334 ? 219.493 218.649 348.038 1.00 53.25  ? 334 ASN B ND2 1 
ATOM   4313 N N   . ILE B 2 335 ? 216.518 217.125 345.408 1.00 44.53  ? 335 ILE B N   1 
ATOM   4314 C CA  . ILE B 2 335 ? 215.064 217.185 345.448 1.00 49.76  ? 335 ILE B CA  1 
ATOM   4315 C C   . ILE B 2 335 ? 214.642 218.273 346.422 1.00 55.90  ? 335 ILE B C   1 
ATOM   4316 O O   . ILE B 2 335 ? 215.177 218.371 347.531 1.00 52.54  ? 335 ILE B O   1 
ATOM   4317 C CB  . ILE B 2 335 ? 214.465 215.827 345.844 1.00 43.61  ? 335 ILE B CB  1 
ATOM   4318 C CG1 . ILE B 2 335 ? 212.954 215.835 345.608 1.00 45.77  ? 335 ILE B CG1 1 
ATOM   4319 C CG2 . ILE B 2 335 ? 214.788 215.509 347.290 1.00 48.14  ? 335 ILE B CG2 1 
ATOM   4320 C CD1 . ILE B 2 335 ? 212.199 214.804 346.404 1.00 52.08  ? 335 ILE B CD1 1 
ATOM   4321 N N   . THR B 2 336 ? 213.702 219.111 345.993 1.00 56.93  ? 336 THR B N   1 
ATOM   4322 C CA  . THR B 2 336 ? 213.142 220.121 346.877 1.00 49.59  ? 336 THR B CA  1 
ATOM   4323 C C   . THR B 2 336 ? 212.412 219.453 348.033 1.00 53.21  ? 336 THR B C   1 
ATOM   4324 O O   . THR B 2 336 ? 211.579 218.566 347.824 1.00 59.54  ? 336 THR B O   1 
ATOM   4325 C CB  . THR B 2 336 ? 212.179 221.019 346.109 1.00 50.86  ? 336 THR B CB  1 
ATOM   4326 O OG1 . THR B 2 336 ? 212.692 221.265 344.798 1.00 53.31  ? 336 THR B OG1 1 
ATOM   4327 C CG2 . THR B 2 336 ? 211.981 222.342 346.839 1.00 52.36  ? 336 THR B CG2 1 
ATOM   4328 N N   . LEU B 2 337 ? 212.717 219.884 349.259 1.00 53.93  ? 337 LEU B N   1 
ATOM   4329 C CA  . LEU B 2 337 ? 212.020 219.425 350.458 1.00 57.91  ? 337 LEU B CA  1 
ATOM   4330 C C   . LEU B 2 337 ? 211.459 220.657 351.160 1.00 57.82  ? 337 LEU B C   1 
ATOM   4331 O O   . LEU B 2 337 ? 212.038 221.139 352.145 1.00 61.30  ? 337 LEU B O   1 
ATOM   4332 C CB  . LEU B 2 337 ? 212.948 218.627 351.373 1.00 60.14  ? 337 LEU B CB  1 
ATOM   4333 C CG  . LEU B 2 337 ? 212.308 218.097 352.659 1.00 65.93  ? 337 LEU B CG  1 
ATOM   4334 C CD1 . LEU B 2 337 ? 211.055 217.273 352.363 1.00 61.07  ? 337 LEU B CD1 1 
ATOM   4335 C CD2 . LEU B 2 337 ? 213.302 217.273 353.461 1.00 61.40  ? 337 LEU B CD2 1 
ATOM   4336 N N   . PRO B 2 338 ? 210.332 221.187 350.691 1.00 61.33  ? 338 PRO B N   1 
ATOM   4337 C CA  . PRO B 2 338 ? 209.820 222.446 351.237 1.00 69.28  ? 338 PRO B CA  1 
ATOM   4338 C C   . PRO B 2 338 ? 209.170 222.270 352.600 1.00 67.97  ? 338 PRO B C   1 
ATOM   4339 O O   . PRO B 2 338 ? 208.805 221.169 353.014 1.00 68.18  ? 338 PRO B O   1 
ATOM   4340 C CB  . PRO B 2 338 ? 208.788 222.885 350.193 1.00 60.00  ? 338 PRO B CB  1 
ATOM   4341 C CG  . PRO B 2 338 ? 208.290 221.617 349.625 1.00 57.94  ? 338 PRO B CG  1 
ATOM   4342 C CD  . PRO B 2 338 ? 209.453 220.657 349.634 1.00 58.64  ? 338 PRO B CD  1 
ATOM   4343 N N   . ARG B 2 339 ? 209.037 223.393 353.301 1.00 73.92  ? 339 ARG B N   1 
ATOM   4344 C CA  . ARG B 2 339 ? 208.327 223.438 354.572 1.00 75.78  ? 339 ARG B CA  1 
ATOM   4345 C C   . ARG B 2 339 ? 206.872 223.790 354.302 1.00 77.95  ? 339 ARG B C   1 
ATOM   4346 O O   . ARG B 2 339 ? 206.579 224.853 353.744 1.00 81.18  ? 339 ARG B O   1 
ATOM   4347 C CB  . ARG B 2 339 ? 208.964 224.455 355.519 1.00 77.94  ? 339 ARG B CB  1 
ATOM   4348 C CG  . ARG B 2 339 ? 208.056 224.887 356.662 1.00 75.42  ? 339 ARG B CG  1 
ATOM   4349 C CD  . ARG B 2 339 ? 208.829 225.560 357.790 1.00 76.97  ? 339 ARG B CD  1 
ATOM   4350 N NE  . ARG B 2 339 ? 209.924 226.391 357.301 1.00 80.60  ? 339 ARG B NE  1 
ATOM   4351 C CZ  . ARG B 2 339 ? 211.198 226.020 357.260 1.00 82.40  ? 339 ARG B CZ  1 
ATOM   4352 N NH1 . ARG B 2 339 ? 211.589 224.828 357.682 1.00 78.07  ? 339 ARG B NH1 1 
ATOM   4353 N NH2 . ARG B 2 339 ? 212.104 226.868 356.783 1.00 80.49  ? 339 ARG B NH2 1 
ATOM   4354 N N   . LEU B 2 340 ? 205.964 222.900 354.699 1.00 76.73  ? 340 LEU B N   1 
ATOM   4355 C CA  . LEU B 2 340 ? 204.550 223.043 354.392 1.00 75.98  ? 340 LEU B CA  1 
ATOM   4356 C C   . LEU B 2 340 ? 203.648 223.048 355.615 1.00 75.51  ? 340 LEU B C   1 
ATOM   4357 O O   . LEU B 2 340 ? 202.491 223.461 355.497 1.00 73.07  ? 340 LEU B O   1 
ATOM   4358 C CB  . LEU B 2 340 ? 204.096 221.915 353.452 1.00 75.91  ? 340 LEU B CB  1 
ATOM   4359 C CG  . LEU B 2 340 ? 204.865 221.813 352.133 1.00 72.90  ? 340 LEU B CG  1 
ATOM   4360 C CD1 . LEU B 2 340 ? 204.563 220.499 351.438 1.00 71.74  ? 340 LEU B CD1 1 
ATOM   4361 C CD2 . LEU B 2 340 ? 204.532 222.986 351.229 1.00 71.52  ? 340 LEU B CD2 1 
ATOM   4362 N N   . GLN B 2 341 ? 204.131 222.603 356.770 1.00 89.36  ? 341 GLN B N   1 
ATOM   4363 C CA  . GLN B 2 341 ? 203.329 222.603 357.989 1.00 90.20  ? 341 GLN B CA  1 
ATOM   4364 C C   . GLN B 2 341 ? 204.102 223.236 359.141 1.00 90.36  ? 341 GLN B C   1 
ATOM   4365 O O   . GLN B 2 341 ? 205.317 223.418 359.067 1.00 88.21  ? 341 GLN B O   1 
ATOM   4366 C CB  . GLN B 2 341 ? 202.906 221.180 358.362 1.00 85.75  ? 341 GLN B CB  1 
ATOM   4367 C CG  . GLN B 2 341 ? 201.958 220.526 357.367 1.00 87.55  ? 341 GLN B CG  1 
ATOM   4368 C CD  . GLN B 2 341 ? 202.657 220.074 356.102 1.00 88.25  ? 341 GLN B CD  1 
ATOM   4369 O OE1 . GLN B 2 341 ? 203.884 220.005 356.049 1.00 86.06  ? 341 GLN B OE1 1 
ATOM   4370 N NE2 . GLN B 2 341 ? 201.876 219.764 355.073 1.00 87.39  ? 341 GLN B NE2 1 
ATOM   4371 O OXT . GLN B 2 341 ? 203.529 223.581 360.174 1.00 89.92  ? 341 GLN B OXT 1 
ATOM   4372 N N   . GLY C 3 1   ? 218.189 278.532 307.709 1.00 46.70  ? 1   GLY C N   1 
ATOM   4373 C CA  . GLY C 3 1   ? 217.466 277.230 307.655 1.00 48.25  ? 1   GLY C CA  1 
ATOM   4374 C C   . GLY C 3 1   ? 216.074 277.363 307.074 1.00 49.21  ? 1   GLY C C   1 
ATOM   4375 O O   . GLY C 3 1   ? 215.692 278.430 306.600 1.00 53.61  ? 1   GLY C O   1 
ATOM   4376 N N   . LEU C 3 2   ? 215.313 276.276 307.116 1.00 42.22  ? 2   LEU C N   1 
ATOM   4377 C CA  . LEU C 3 2   ? 213.974 276.293 306.552 1.00 49.32  ? 2   LEU C CA  1 
ATOM   4378 C C   . LEU C 3 2   ? 213.103 277.291 307.315 1.00 54.10  ? 2   LEU C C   1 
ATOM   4379 O O   . LEU C 3 2   ? 213.182 277.362 308.546 1.00 57.39  ? 2   LEU C O   1 
ATOM   4380 C CB  . LEU C 3 2   ? 213.353 274.898 306.615 1.00 42.63  ? 2   LEU C CB  1 
ATOM   4381 C CG  . LEU C 3 2   ? 212.009 274.718 305.909 1.00 39.81  ? 2   LEU C CG  1 
ATOM   4382 C CD1 . LEU C 3 2   ? 212.162 274.885 304.409 1.00 43.91  ? 2   LEU C CD1 1 
ATOM   4383 C CD2 . LEU C 3 2   ? 211.418 273.361 306.234 1.00 44.45  ? 2   LEU C CD2 1 
ATOM   4384 N N   . PRO C 3 3   ? 212.273 278.082 306.629 1.00 36.42  ? 3   PRO C N   1 
ATOM   4385 C CA  . PRO C 3 3   ? 211.357 278.977 307.349 1.00 33.00  ? 3   PRO C CA  1 
ATOM   4386 C C   . PRO C 3 3   ? 210.096 278.235 307.769 1.00 43.48  ? 3   PRO C C   1 
ATOM   4387 O O   . PRO C 3 3   ? 209.426 277.610 306.944 1.00 48.20  ? 3   PRO C O   1 
ATOM   4388 C CB  . PRO C 3 3   ? 211.041 280.073 306.324 1.00 30.52  ? 3   PRO C CB  1 
ATOM   4389 C CG  . PRO C 3 3   ? 211.927 279.809 305.149 1.00 36.37  ? 3   PRO C CG  1 
ATOM   4390 C CD  . PRO C 3 3   ? 212.252 278.362 305.187 1.00 32.17  ? 3   PRO C CD  1 
ATOM   4391 N N   . VAL C 3 4   ? 209.772 278.310 309.058 1.00 42.73  ? 4   VAL C N   1 
ATOM   4392 C CA  . VAL C 3 4   ? 208.591 277.645 309.595 1.00 35.00  ? 4   VAL C CA  1 
ATOM   4393 C C   . VAL C 3 4   ? 207.702 278.670 310.286 1.00 38.05  ? 4   VAL C C   1 
ATOM   4394 O O   . VAL C 3 4   ? 208.038 279.856 310.350 1.00 42.33  ? 4   VAL C O   1 
ATOM   4395 C CB  . VAL C 3 4   ? 208.981 276.513 310.561 1.00 30.36  ? 4   VAL C CB  1 
ATOM   4396 C CG1 . VAL C 3 4   ? 209.797 275.460 309.838 1.00 29.89  ? 4   VAL C CG1 1 
ATOM   4397 C CG2 . VAL C 3 4   ? 209.752 277.063 311.747 1.00 32.73  ? 4   VAL C CG2 1 
ATOM   4398 N N   . MET C 3 5   ? 206.560 278.220 310.800 1.00 44.35  ? 5   MET C N   1 
ATOM   4399 C CA  . MET C 3 5   ? 205.636 279.102 311.509 1.00 34.98  ? 5   MET C CA  1 
ATOM   4400 C C   . MET C 3 5   ? 204.830 278.250 312.478 1.00 39.40  ? 5   MET C C   1 
ATOM   4401 O O   . MET C 3 5   ? 203.933 277.516 312.057 1.00 48.66  ? 5   MET C O   1 
ATOM   4402 C CB  . MET C 3 5   ? 204.721 279.834 310.534 1.00 39.87  ? 5   MET C CB  1 
ATOM   4403 C CG  . MET C 3 5   ? 203.791 280.832 311.194 1.00 44.75  ? 5   MET C CG  1 
ATOM   4404 S SD  . MET C 3 5   ? 202.655 281.601 310.030 1.00 54.51  ? 5   MET C SD  1 
ATOM   4405 C CE  . MET C 3 5   ? 201.640 280.201 309.574 1.00 43.46  ? 5   MET C CE  1 
ATOM   4406 N N   . ASN C 3 6   ? 205.144 278.350 313.768 1.00 32.47  ? 6   ASN C N   1 
ATOM   4407 C CA  . ASN C 3 6   ? 204.462 277.550 314.776 1.00 34.71  ? 6   ASN C CA  1 
ATOM   4408 C C   . ASN C 3 6   ? 202.980 277.891 314.829 1.00 44.26  ? 6   ASN C C   1 
ATOM   4409 O O   . ASN C 3 6   ? 202.603 278.989 315.249 1.00 48.21  ? 6   ASN C O   1 
ATOM   4410 C CB  . ASN C 3 6   ? 205.095 277.763 316.150 1.00 34.59  ? 6   ASN C CB  1 
ATOM   4411 C CG  . ASN C 3 6   ? 206.569 277.436 316.165 1.00 44.32  ? 6   ASN C CG  1 
ATOM   4412 O OD1 . ASN C 3 6   ? 206.957 276.275 316.278 1.00 48.11  ? 6   ASN C OD1 1 
ATOM   4413 N ND2 . ASN C 3 6   ? 207.402 278.461 316.056 1.00 49.59  ? 6   ASN C ND2 1 
ATOM   4414 N N   . THR C 3 7   ? 202.136 276.958 314.410 1.00 45.72  ? 7   THR C N   1 
ATOM   4415 C CA  . THR C 3 7   ? 200.699 277.154 314.453 1.00 39.31  ? 7   THR C CA  1 
ATOM   4416 C C   . THR C 3 7   ? 200.187 277.001 315.879 1.00 38.73  ? 7   THR C C   1 
ATOM   4417 O O   . THR C 3 7   ? 200.885 276.474 316.747 1.00 48.43  ? 7   THR C O   1 
ATOM   4418 C CB  . THR C 3 7   ? 199.998 276.146 313.551 1.00 37.50  ? 7   THR C CB  1 
ATOM   4419 O OG1 . THR C 3 7   ? 200.133 274.833 314.106 1.00 40.63  ? 7   THR C OG1 1 
ATOM   4420 C CG2 . THR C 3 7   ? 200.600 276.163 312.158 1.00 46.09  ? 7   THR C CG2 1 
ATOM   4421 N N   . PRO C 3 8   ? 198.968 277.461 316.152 1.00 35.13  ? 8   PRO C N   1 
ATOM   4422 C CA  . PRO C 3 8   ? 198.378 277.214 317.469 1.00 32.22  ? 8   PRO C CA  1 
ATOM   4423 C C   . PRO C 3 8   ? 198.281 275.723 317.741 1.00 38.84  ? 8   PRO C C   1 
ATOM   4424 O O   . PRO C 3 8   ? 198.122 274.911 316.828 1.00 35.70  ? 8   PRO C O   1 
ATOM   4425 C CB  . PRO C 3 8   ? 196.993 277.859 317.368 1.00 35.60  ? 8   PRO C CB  1 
ATOM   4426 C CG  . PRO C 3 8   ? 197.130 278.877 316.303 1.00 39.17  ? 8   PRO C CG  1 
ATOM   4427 C CD  . PRO C 3 8   ? 198.107 278.314 315.318 1.00 41.44  ? 8   PRO C CD  1 
ATOM   4428 N N   . GLY C 3 9   ? 198.387 275.368 319.015 1.00 43.40  ? 9   GLY C N   1 
ATOM   4429 C CA  . GLY C 3 9   ? 198.450 273.981 319.410 1.00 35.19  ? 9   GLY C CA  1 
ATOM   4430 C C   . GLY C 3 9   ? 199.849 273.439 319.560 1.00 36.61  ? 9   GLY C C   1 
ATOM   4431 O O   . GLY C 3 9   ? 200.017 272.217 319.630 1.00 44.46  ? 9   GLY C O   1 
ATOM   4432 N N   . SER C 3 10  ? 200.856 274.304 319.602 1.00 42.84  ? 10  SER C N   1 
ATOM   4433 C CA  . SER C 3 10  ? 202.236 273.891 319.786 1.00 44.63  ? 10  SER C CA  1 
ATOM   4434 C C   . SER C 3 10  ? 202.590 273.886 321.266 1.00 45.78  ? 10  SER C C   1 
ATOM   4435 O O   . SER C 3 10  ? 202.011 274.622 322.066 1.00 50.98  ? 10  SER C O   1 
ATOM   4436 C CB  . SER C 3 10  ? 203.180 274.825 319.033 1.00 44.57  ? 10  SER C CB  1 
ATOM   4437 O OG  . SER C 3 10  ? 202.806 274.935 317.674 1.00 48.28  ? 10  SER C OG  1 
ATOM   4438 N N   . ASN C 3 11  ? 203.554 273.041 321.623 1.00 44.84  ? 11  ASN C N   1 
ATOM   4439 C CA  . ASN C 3 11  ? 204.057 272.966 322.992 1.00 42.50  ? 11  ASN C CA  1 
ATOM   4440 C C   . ASN C 3 11  ? 202.942 272.668 323.987 1.00 45.00  ? 11  ASN C C   1 
ATOM   4441 O O   . ASN C 3 11  ? 202.969 273.138 325.126 1.00 51.37  ? 11  ASN C O   1 
ATOM   4442 C CB  . ASN C 3 11  ? 204.784 274.255 323.381 1.00 43.55  ? 11  ASN C CB  1 
ATOM   4443 C CG  . ASN C 3 11  ? 206.016 274.505 322.539 1.00 49.60  ? 11  ASN C CG  1 
ATOM   4444 O OD1 . ASN C 3 11  ? 207.103 274.026 322.855 1.00 50.81  ? 11  ASN C OD1 1 
ATOM   4445 N ND2 . ASN C 3 11  ? 205.854 275.259 321.462 1.00 52.26  ? 11  ASN C ND2 1 
ATOM   4446 N N   . GLN C 3 12  ? 201.952 271.887 323.566 1.00 38.49  ? 12  GLN C N   1 
ATOM   4447 C CA  . GLN C 3 12  ? 200.892 271.417 324.443 1.00 40.05  ? 12  GLN C CA  1 
ATOM   4448 C C   . GLN C 3 12  ? 200.950 269.901 324.521 1.00 44.56  ? 12  GLN C C   1 
ATOM   4449 O O   . GLN C 3 12  ? 201.291 269.227 323.545 1.00 49.61  ? 12  GLN C O   1 
ATOM   4450 C CB  . GLN C 3 12  ? 199.509 271.851 323.944 1.00 39.26  ? 12  GLN C CB  1 
ATOM   4451 C CG  . GLN C 3 12  ? 198.905 270.905 322.916 1.00 41.54  ? 12  GLN C CG  1 
ATOM   4452 C CD  . GLN C 3 12  ? 197.623 271.429 322.323 1.00 41.65  ? 12  GLN C CD  1 
ATOM   4453 O OE1 . GLN C 3 12  ? 197.076 272.428 322.785 1.00 50.67  ? 12  GLN C OE1 1 
ATOM   4454 N NE2 . GLN C 3 12  ? 197.133 270.756 321.291 1.00 40.74  ? 12  GLN C NE2 1 
ATOM   4455 N N   . TYR C 3 13  ? 200.609 269.365 325.685 1.00 42.60  ? 13  TYR C N   1 
ATOM   4456 C CA  . TYR C 3 13  ? 200.530 267.923 325.887 1.00 39.65  ? 13  TYR C CA  1 
ATOM   4457 C C   . TYR C 3 13  ? 199.062 267.526 325.821 1.00 45.90  ? 13  TYR C C   1 
ATOM   4458 O O   . TYR C 3 13  ? 198.303 267.749 326.767 1.00 53.53  ? 13  TYR C O   1 
ATOM   4459 C CB  . TYR C 3 13  ? 201.159 267.515 327.214 1.00 43.54  ? 13  TYR C CB  1 
ATOM   4460 C CG  . TYR C 3 13  ? 200.926 266.066 327.579 1.00 44.70  ? 13  TYR C CG  1 
ATOM   4461 C CD1 . TYR C 3 13  ? 200.849 265.086 326.601 1.00 44.24  ? 13  TYR C CD1 1 
ATOM   4462 C CD2 . TYR C 3 13  ? 200.770 265.681 328.901 1.00 46.53  ? 13  TYR C CD2 1 
ATOM   4463 C CE1 . TYR C 3 13  ? 200.630 263.767 326.931 1.00 43.85  ? 13  TYR C CE1 1 
ATOM   4464 C CE2 . TYR C 3 13  ? 200.551 264.363 329.238 1.00 47.69  ? 13  TYR C CE2 1 
ATOM   4465 C CZ  . TYR C 3 13  ? 200.482 263.411 328.250 1.00 47.51  ? 13  TYR C CZ  1 
ATOM   4466 O OH  . TYR C 3 13  ? 200.265 262.093 328.579 1.00 52.91  ? 13  TYR C OH  1 
ATOM   4467 N N   . LEU C 3 14  ? 198.665 266.946 324.696 1.00 43.29  ? 14  LEU C N   1 
ATOM   4468 C CA  . LEU C 3 14  ? 197.359 266.325 324.547 1.00 47.33  ? 14  LEU C CA  1 
ATOM   4469 C C   . LEU C 3 14  ? 197.516 264.835 324.803 1.00 57.01  ? 14  LEU C C   1 
ATOM   4470 O O   . LEU C 3 14  ? 198.378 264.187 324.201 1.00 62.77  ? 14  LEU C O   1 
ATOM   4471 C CB  . LEU C 3 14  ? 196.792 266.575 323.150 1.00 46.25  ? 14  LEU C CB  1 
ATOM   4472 C CG  . LEU C 3 14  ? 195.467 265.895 322.802 1.00 43.50  ? 14  LEU C CG  1 
ATOM   4473 C CD1 . LEU C 3 14  ? 194.329 266.451 323.635 1.00 45.01  ? 14  LEU C CD1 1 
ATOM   4474 C CD2 . LEU C 3 14  ? 195.177 266.051 321.324 1.00 50.16  ? 14  LEU C CD2 1 
ATOM   4475 N N   . THR C 3 15  ? 196.692 264.293 325.695 1.00 55.48  ? 15  THR C N   1 
ATOM   4476 C CA  . THR C 3 15  ? 196.844 262.912 326.125 1.00 46.36  ? 15  THR C CA  1 
ATOM   4477 C C   . THR C 3 15  ? 196.173 261.927 325.187 1.00 50.57  ? 15  THR C C   1 
ATOM   4478 O O   . THR C 3 15  ? 195.900 260.793 325.593 1.00 60.48  ? 15  THR C O   1 
ATOM   4479 C CB  . THR C 3 15  ? 196.289 262.734 327.538 1.00 47.18  ? 15  THR C CB  1 
ATOM   4480 O OG1 . THR C 3 15  ? 194.859 262.759 327.496 1.00 52.46  ? 15  THR C OG1 1 
ATOM   4481 C CG2 . THR C 3 15  ? 196.785 263.842 328.450 1.00 37.59  ? 15  THR C CG2 1 
ATOM   4482 N N   . ALA C 3 16  ? 195.896 262.330 323.947 1.00 50.44  ? 16  ALA C N   1 
ATOM   4483 C CA  . ALA C 3 16  ? 195.304 261.441 322.958 1.00 53.46  ? 16  ALA C CA  1 
ATOM   4484 C C   . ALA C 3 16  ? 195.950 261.629 321.592 1.00 55.74  ? 16  ALA C C   1 
ATOM   4485 O O   . ALA C 3 16  ? 195.293 261.445 320.562 1.00 56.82  ? 16  ALA C O   1 
ATOM   4486 C CB  . ALA C 3 16  ? 193.795 261.663 322.857 1.00 53.40  ? 16  ALA C CB  1 
ATOM   4487 N N   . ASP C 3 17  ? 197.229 261.992 321.562 1.00 61.34  ? 17  ASP C N   1 
ATOM   4488 C CA  . ASP C 3 17  ? 197.944 262.267 320.325 1.00 59.86  ? 17  ASP C CA  1 
ATOM   4489 C C   . ASP C 3 17  ? 198.984 261.185 320.070 1.00 58.39  ? 17  ASP C C   1 
ATOM   4490 O O   . ASP C 3 17  ? 199.705 260.775 320.984 1.00 57.13  ? 17  ASP C O   1 
ATOM   4491 C CB  . ASP C 3 17  ? 198.624 263.639 320.374 1.00 57.93  ? 17  ASP C CB  1 
ATOM   4492 C CG  . ASP C 3 17  ? 199.648 263.744 321.484 1.00 64.73  ? 17  ASP C CG  1 
ATOM   4493 O OD1 . ASP C 3 17  ? 199.674 262.855 322.359 1.00 68.14  ? 17  ASP C OD1 1 
ATOM   4494 O OD2 . ASP C 3 17  ? 200.431 264.715 321.481 1.00 63.24  ? 17  ASP C OD2 1 
ATOM   4495 N N   . ASN C 3 18  ? 199.051 260.724 318.822 1.00 53.69  ? 18  ASN C N   1 
ATOM   4496 C CA  . ASN C 3 18  ? 199.987 259.676 318.423 1.00 55.31  ? 18  ASN C CA  1 
ATOM   4497 C C   . ASN C 3 18  ? 201.178 260.336 317.734 1.00 57.83  ? 18  ASN C C   1 
ATOM   4498 O O   . ASN C 3 18  ? 201.259 260.423 316.510 1.00 59.23  ? 18  ASN C O   1 
ATOM   4499 C CB  . ASN C 3 18  ? 199.297 258.663 317.519 1.00 54.26  ? 18  ASN C CB  1 
ATOM   4500 C CG  . ASN C 3 18  ? 198.052 258.077 318.149 1.00 57.20  ? 18  ASN C CG  1 
ATOM   4501 O OD1 . ASN C 3 18  ? 197.981 257.907 319.365 1.00 55.27  ? 18  ASN C OD1 1 
ATOM   4502 N ND2 . ASN C 3 18  ? 197.060 257.770 317.324 1.00 61.29  ? 18  ASN C ND2 1 
ATOM   4503 N N   . PHE C 3 19  ? 202.119 260.803 318.549 1.00 49.28  ? 19  PHE C N   1 
ATOM   4504 C CA  . PHE C 3 19  ? 203.330 261.451 318.069 1.00 45.99  ? 19  PHE C CA  1 
ATOM   4505 C C   . PHE C 3 19  ? 204.547 260.611 318.426 1.00 49.54  ? 19  PHE C C   1 
ATOM   4506 O O   . PHE C 3 19  ? 204.655 260.096 319.543 1.00 54.44  ? 19  PHE C O   1 
ATOM   4507 C CB  . PHE C 3 19  ? 203.482 262.854 318.664 1.00 41.98  ? 19  PHE C CB  1 
ATOM   4508 C CG  . PHE C 3 19  ? 202.482 263.854 318.150 1.00 48.89  ? 19  PHE C CG  1 
ATOM   4509 C CD1 . PHE C 3 19  ? 201.785 263.636 316.975 1.00 51.00  ? 19  PHE C CD1 1 
ATOM   4510 C CD2 . PHE C 3 19  ? 202.249 265.024 318.846 1.00 53.05  ? 19  PHE C CD2 1 
ATOM   4511 C CE1 . PHE C 3 19  ? 200.874 264.561 316.513 1.00 46.85  ? 19  PHE C CE1 1 
ATOM   4512 C CE2 . PHE C 3 19  ? 201.340 265.951 318.385 1.00 49.08  ? 19  PHE C CE2 1 
ATOM   4513 C CZ  . PHE C 3 19  ? 200.653 265.718 317.219 1.00 45.01  ? 19  PHE C CZ  1 
ATOM   4514 N N   . GLN C 3 20  ? 205.460 260.478 317.469 1.00 55.95  ? 20  GLN C N   1 
ATOM   4515 C CA  . GLN C 3 20  ? 206.695 259.749 317.707 1.00 51.20  ? 20  GLN C CA  1 
ATOM   4516 C C   . GLN C 3 20  ? 207.571 260.507 318.693 1.00 55.77  ? 20  GLN C C   1 
ATOM   4517 O O   . GLN C 3 20  ? 207.654 261.737 318.657 1.00 62.51  ? 20  GLN C O   1 
ATOM   4518 C CB  . GLN C 3 20  ? 207.445 259.542 316.394 1.00 48.30  ? 20  GLN C CB  1 
ATOM   4519 C CG  . GLN C 3 20  ? 206.645 258.813 315.335 1.00 54.65  ? 20  GLN C CG  1 
ATOM   4520 C CD  . GLN C 3 20  ? 207.241 258.968 313.955 1.00 63.72  ? 20  GLN C CD  1 
ATOM   4521 O OE1 . GLN C 3 20  ? 208.211 259.700 313.765 1.00 62.66  ? 20  GLN C OE1 1 
ATOM   4522 N NE2 . GLN C 3 20  ? 206.661 258.280 312.979 1.00 66.65  ? 20  GLN C NE2 1 
ATOM   4523 N N   . SER C 3 21  ? 208.229 259.765 319.576 1.00 56.53  ? 21  SER C N   1 
ATOM   4524 C CA  . SER C 3 21  ? 209.107 260.339 320.580 1.00 55.88  ? 21  SER C CA  1 
ATOM   4525 C C   . SER C 3 21  ? 210.428 259.586 320.603 1.00 54.00  ? 21  SER C C   1 
ATOM   4526 O O   . SER C 3 21  ? 210.477 258.402 320.260 1.00 54.89  ? 21  SER C O   1 
ATOM   4527 C CB  . SER C 3 21  ? 208.461 260.286 321.970 1.00 57.95  ? 21  SER C CB  1 
ATOM   4528 O OG  . SER C 3 21  ? 208.006 258.979 322.266 1.00 63.72  ? 21  SER C OG  1 
ATOM   4529 N N   . PRO C 3 22  ? 211.513 260.247 321.000 1.00 43.40  ? 22  PRO C N   1 
ATOM   4530 C CA  . PRO C 3 22  ? 212.813 259.569 321.019 1.00 46.74  ? 22  PRO C CA  1 
ATOM   4531 C C   . PRO C 3 22  ? 212.820 258.409 322.001 1.00 46.80  ? 22  PRO C C   1 
ATOM   4532 O O   . PRO C 3 22  ? 212.212 258.471 323.071 1.00 47.47  ? 22  PRO C O   1 
ATOM   4533 C CB  . PRO C 3 22  ? 213.783 260.675 321.442 1.00 50.27  ? 22  PRO C CB  1 
ATOM   4534 C CG  . PRO C 3 22  ? 212.943 261.647 322.185 1.00 47.33  ? 22  PRO C CG  1 
ATOM   4535 C CD  . PRO C 3 22  ? 211.606 261.623 321.515 1.00 42.63  ? 22  PRO C CD  1 
ATOM   4536 N N   . CYS C 3 23  ? 213.521 257.344 321.627 1.00 45.52  ? 23  CYS C N   1 
ATOM   4537 C CA  . CYS C 3 23  ? 213.642 256.174 322.484 1.00 46.57  ? 23  CYS C CA  1 
ATOM   4538 C C   . CYS C 3 23  ? 214.726 256.412 323.526 1.00 38.99  ? 23  CYS C C   1 
ATOM   4539 O O   . CYS C 3 23  ? 215.823 256.872 323.198 1.00 36.00  ? 23  CYS C O   1 
ATOM   4540 C CB  . CYS C 3 23  ? 213.969 254.936 321.651 1.00 44.40  ? 23  CYS C CB  1 
ATOM   4541 S SG  . CYS C 3 23  ? 214.020 253.391 322.583 1.00 49.07  ? 23  CYS C SG  1 
ATOM   4542 N N   . ALA C 3 24  ? 214.413 256.107 324.782 1.00 34.47  ? 24  ALA C N   1 
ATOM   4543 C CA  . ALA C 3 24  ? 215.368 256.257 325.869 1.00 31.29  ? 24  ALA C CA  1 
ATOM   4544 C C   . ALA C 3 24  ? 216.235 255.024 326.073 1.00 32.78  ? 24  ALA C C   1 
ATOM   4545 O O   . ALA C 3 24  ? 217.185 255.078 326.859 1.00 40.90  ? 24  ALA C O   1 
ATOM   4546 C CB  . ALA C 3 24  ? 214.635 256.580 327.172 1.00 31.23  ? 24  ALA C CB  1 
ATOM   4547 N N   . LEU C 3 25  ? 215.935 253.923 325.389 1.00 31.66  ? 25  LEU C N   1 
ATOM   4548 C CA  . LEU C 3 25  ? 216.712 252.689 325.473 1.00 33.92  ? 25  LEU C CA  1 
ATOM   4549 C C   . LEU C 3 25  ? 217.037 252.235 324.057 1.00 36.62  ? 25  LEU C C   1 
ATOM   4550 O O   . LEU C 3 25  ? 216.489 251.243 323.564 1.00 39.46  ? 25  LEU C O   1 
ATOM   4551 C CB  . LEU C 3 25  ? 215.947 251.612 326.241 1.00 36.42  ? 25  LEU C CB  1 
ATOM   4552 C CG  . LEU C 3 25  ? 215.633 251.959 327.698 1.00 36.30  ? 25  LEU C CG  1 
ATOM   4553 C CD1 . LEU C 3 25  ? 214.718 250.924 328.322 1.00 38.73  ? 25  LEU C CD1 1 
ATOM   4554 C CD2 . LEU C 3 25  ? 216.914 252.075 328.499 1.00 37.33  ? 25  LEU C CD2 1 
ATOM   4555 N N   . PRO C 3 26  ? 217.921 252.951 323.369 1.00 40.09  ? 26  PRO C N   1 
ATOM   4556 C CA  . PRO C 3 26  ? 218.223 252.606 321.977 1.00 43.47  ? 26  PRO C CA  1 
ATOM   4557 C C   . PRO C 3 26  ? 218.892 251.248 321.856 1.00 47.88  ? 26  PRO C C   1 
ATOM   4558 O O   . PRO C 3 26  ? 219.649 250.818 322.729 1.00 41.93  ? 26  PRO C O   1 
ATOM   4559 C CB  . PRO C 3 26  ? 219.162 253.731 321.530 1.00 47.53  ? 26  PRO C CB  1 
ATOM   4560 C CG  . PRO C 3 26  ? 219.761 254.247 322.787 1.00 46.82  ? 26  PRO C CG  1 
ATOM   4561 C CD  . PRO C 3 26  ? 218.705 254.106 323.834 1.00 43.00  ? 26  PRO C CD  1 
ATOM   4562 N N   . GLU C 3 27  ? 218.600 250.570 320.746 1.00 56.62  ? 27  GLU C N   1 
ATOM   4563 C CA  . GLU C 3 27  ? 219.108 249.245 320.407 1.00 56.74  ? 27  GLU C CA  1 
ATOM   4564 C C   . GLU C 3 27  ? 218.622 248.170 321.367 1.00 59.83  ? 27  GLU C C   1 
ATOM   4565 O O   . GLU C 3 27  ? 219.025 247.011 321.229 1.00 66.39  ? 27  GLU C O   1 
ATOM   4566 C CB  . GLU C 3 27  ? 220.642 249.203 320.362 1.00 58.82  ? 27  GLU C CB  1 
ATOM   4567 C CG  . GLU C 3 27  ? 221.247 249.900 319.158 1.00 61.83  ? 27  GLU C CG  1 
ATOM   4568 C CD  . GLU C 3 27  ? 221.038 249.126 317.873 1.00 66.72  ? 27  GLU C CD  1 
ATOM   4569 O OE1 . GLU C 3 27  ? 220.289 248.127 317.893 1.00 64.00  ? 27  GLU C OE1 1 
ATOM   4570 O OE2 . GLU C 3 27  ? 221.625 249.513 316.841 1.00 67.97  ? 27  GLU C OE2 1 
ATOM   4571 N N   . PHE C 3 28  ? 217.768 248.510 322.330 1.00 49.30  ? 28  PHE C N   1 
ATOM   4572 C CA  . PHE C 3 28  ? 217.316 247.567 323.343 1.00 40.13  ? 28  PHE C CA  1 
ATOM   4573 C C   . PHE C 3 28  ? 216.726 246.320 322.698 1.00 44.42  ? 28  PHE C C   1 
ATOM   4574 O O   . PHE C 3 28  ? 215.689 246.390 322.032 1.00 40.96  ? 28  PHE C O   1 
ATOM   4575 C CB  . PHE C 3 28  ? 216.286 248.246 324.248 1.00 38.78  ? 28  PHE C CB  1 
ATOM   4576 C CG  . PHE C 3 28  ? 215.840 247.411 325.411 1.00 30.35  ? 28  PHE C CG  1 
ATOM   4577 C CD1 . PHE C 3 28  ? 214.902 246.412 325.246 1.00 41.60  ? 28  PHE C CD1 1 
ATOM   4578 C CD2 . PHE C 3 28  ? 216.335 247.650 326.676 1.00 34.41  ? 28  PHE C CD2 1 
ATOM   4579 C CE1 . PHE C 3 28  ? 214.485 245.653 326.317 1.00 44.46  ? 28  PHE C CE1 1 
ATOM   4580 C CE2 . PHE C 3 28  ? 215.918 246.895 327.748 1.00 38.73  ? 28  PHE C CE2 1 
ATOM   4581 C CZ  . PHE C 3 28  ? 214.994 245.897 327.569 1.00 45.68  ? 28  PHE C CZ  1 
ATOM   4582 N N   . ASP C 3 29  ? 217.381 245.178 322.886 1.00 54.75  ? 29  ASP C N   1 
ATOM   4583 C CA  . ASP C 3 29  ? 216.846 243.921 322.385 1.00 52.63  ? 29  ASP C CA  1 
ATOM   4584 C C   . ASP C 3 29  ? 215.566 243.569 323.129 1.00 59.81  ? 29  ASP C C   1 
ATOM   4585 O O   . ASP C 3 29  ? 215.490 243.682 324.355 1.00 63.36  ? 29  ASP C O   1 
ATOM   4586 C CB  . ASP C 3 29  ? 217.875 242.806 322.549 1.00 52.91  ? 29  ASP C CB  1 
ATOM   4587 C CG  . ASP C 3 29  ? 217.364 241.467 322.067 1.00 61.38  ? 29  ASP C CG  1 
ATOM   4588 O OD1 . ASP C 3 29  ? 216.293 241.431 321.428 1.00 61.92  ? 29  ASP C OD1 1 
ATOM   4589 O OD2 . ASP C 3 29  ? 218.035 240.448 322.331 1.00 62.69  ? 29  ASP C OD2 1 
ATOM   4590 N N   . VAL C 3 30  ? 214.559 243.124 322.383 1.00 49.10  ? 30  VAL C N   1 
ATOM   4591 C CA  . VAL C 3 30  ? 213.218 242.903 322.911 1.00 44.44  ? 30  VAL C CA  1 
ATOM   4592 C C   . VAL C 3 30  ? 212.952 241.406 322.957 1.00 47.03  ? 30  VAL C C   1 
ATOM   4593 O O   . VAL C 3 30  ? 213.188 240.696 321.972 1.00 53.33  ? 30  VAL C O   1 
ATOM   4594 C CB  . VAL C 3 30  ? 212.158 243.619 322.058 1.00 41.62  ? 30  VAL C CB  1 
ATOM   4595 C CG1 . VAL C 3 30  ? 210.814 243.598 322.759 1.00 47.48  ? 30  VAL C CG1 1 
ATOM   4596 C CG2 . VAL C 3 30  ? 212.593 245.042 321.764 1.00 42.73  ? 30  VAL C CG2 1 
ATOM   4597 N N   . THR C 3 31  ? 212.462 240.931 324.093 1.00 39.86  ? 31  THR C N   1 
ATOM   4598 C CA  . THR C 3 31  ? 212.085 239.534 324.225 1.00 37.35  ? 31  THR C CA  1 
ATOM   4599 C C   . THR C 3 31  ? 210.983 239.215 323.220 1.00 47.37  ? 31  THR C C   1 
ATOM   4600 O O   . THR C 3 31  ? 209.934 239.875 323.237 1.00 51.70  ? 31  THR C O   1 
ATOM   4601 C CB  . THR C 3 31  ? 211.601 239.245 325.642 1.00 40.29  ? 31  THR C CB  1 
ATOM   4602 O OG1 . THR C 3 31  ? 212.649 239.525 326.576 1.00 42.11  ? 31  THR C OG1 1 
ATOM   4603 C CG2 . THR C 3 31  ? 211.179 237.794 325.779 1.00 42.46  ? 31  THR C CG2 1 
ATOM   4604 N N   . PRO C 3 32  ? 211.162 238.223 322.345 1.00 42.02  ? 32  PRO C N   1 
ATOM   4605 C CA  . PRO C 3 32  ? 210.158 237.982 321.314 1.00 45.07  ? 32  PRO C CA  1 
ATOM   4606 C C   . PRO C 3 32  ? 208.848 237.541 321.926 1.00 49.68  ? 32  PRO C C   1 
ATOM   4607 O O   . PRO C 3 32  ? 208.827 236.886 322.985 1.00 55.10  ? 32  PRO C O   1 
ATOM   4608 C CB  . PRO C 3 32  ? 210.789 236.865 320.463 1.00 43.06  ? 32  PRO C CB  1 
ATOM   4609 C CG  . PRO C 3 32  ? 211.686 236.159 321.399 1.00 45.64  ? 32  PRO C CG  1 
ATOM   4610 C CD  . PRO C 3 32  ? 212.231 237.211 322.315 1.00 36.19  ? 32  PRO C CD  1 
ATOM   4611 N N   . PRO C 3 33  ? 207.716 237.874 321.308 1.00 44.67  ? 33  PRO C N   1 
ATOM   4612 C CA  . PRO C 3 33  ? 206.434 237.389 321.817 1.00 43.99  ? 33  PRO C CA  1 
ATOM   4613 C C   . PRO C 3 33  ? 206.278 235.896 321.588 1.00 48.59  ? 33  PRO C C   1 
ATOM   4614 O O   . PRO C 3 33  ? 206.855 235.321 320.663 1.00 53.30  ? 33  PRO C O   1 
ATOM   4615 C CB  . PRO C 3 33  ? 205.407 238.187 321.010 1.00 46.14  ? 33  PRO C CB  1 
ATOM   4616 C CG  . PRO C 3 33  ? 206.102 238.489 319.736 1.00 42.34  ? 33  PRO C CG  1 
ATOM   4617 C CD  . PRO C 3 33  ? 207.551 238.679 320.085 1.00 44.82  ? 33  PRO C CD  1 
ATOM   4618 N N   . ILE C 3 34  ? 205.477 235.268 322.448 1.00 52.64  ? 34  ILE C N   1 
ATOM   4619 C CA  . ILE C 3 34  ? 205.186 233.846 322.349 1.00 51.89  ? 34  ILE C CA  1 
ATOM   4620 C C   . ILE C 3 34  ? 203.677 233.664 322.335 1.00 56.00  ? 34  ILE C C   1 
ATOM   4621 O O   . ILE C 3 34  ? 202.919 234.513 322.807 1.00 57.61  ? 34  ILE C O   1 
ATOM   4622 C CB  . ILE C 3 34  ? 205.814 233.034 323.500 1.00 49.09  ? 34  ILE C CB  1 
ATOM   4623 C CG1 . ILE C 3 34  ? 205.235 233.470 324.848 1.00 50.43  ? 34  ILE C CG1 1 
ATOM   4624 C CG2 . ILE C 3 34  ? 207.321 233.199 323.491 1.00 52.81  ? 34  ILE C CG2 1 
ATOM   4625 C CD1 . ILE C 3 34  ? 205.800 232.714 326.023 1.00 52.47  ? 34  ILE C CD1 1 
ATOM   4626 N N   . ASP C 3 35  ? 203.246 232.531 321.788 1.00 59.23  ? 35  ASP C N   1 
ATOM   4627 C CA  . ASP C 3 35  ? 201.822 232.260 321.654 1.00 57.68  ? 35  ASP C CA  1 
ATOM   4628 C C   . ASP C 3 35  ? 201.219 231.919 323.011 1.00 59.29  ? 35  ASP C C   1 
ATOM   4629 O O   . ASP C 3 35  ? 201.240 230.759 323.434 1.00 58.38  ? 35  ASP C O   1 
ATOM   4630 C CB  . ASP C 3 35  ? 201.589 231.122 320.660 1.00 58.35  ? 35  ASP C CB  1 
ATOM   4631 C CG  . ASP C 3 35  ? 200.155 231.058 320.175 1.00 65.29  ? 35  ASP C CG  1 
ATOM   4632 O OD1 . ASP C 3 35  ? 199.339 231.893 320.615 1.00 64.80  ? 35  ASP C OD1 1 
ATOM   4633 O OD2 . ASP C 3 35  ? 199.843 230.174 319.351 1.00 65.15  ? 35  ASP C OD2 1 
ATOM   4634 N N   . ILE C 3 36  ? 200.689 232.925 323.699 1.00 52.00  ? 36  ILE C N   1 
ATOM   4635 C CA  . ILE C 3 36  ? 200.021 232.730 324.983 1.00 47.57  ? 36  ILE C CA  1 
ATOM   4636 C C   . ILE C 3 36  ? 198.534 232.534 324.709 1.00 50.32  ? 36  ILE C C   1 
ATOM   4637 O O   . ILE C 3 36  ? 197.917 233.385 324.055 1.00 51.84  ? 36  ILE C O   1 
ATOM   4638 C CB  . ILE C 3 36  ? 200.263 233.915 325.930 1.00 50.28  ? 36  ILE C CB  1 
ATOM   4639 C CG1 . ILE C 3 36  ? 201.765 234.149 326.108 1.00 51.12  ? 36  ILE C CG1 1 
ATOM   4640 C CG2 . ILE C 3 36  ? 199.600 233.665 327.278 1.00 45.64  ? 36  ILE C CG2 1 
ATOM   4641 C CD1 . ILE C 3 36  ? 202.108 235.271 327.062 1.00 50.64  ? 36  ILE C CD1 1 
ATOM   4642 N N   . PRO C 3 37  ? 197.919 231.445 325.169 1.00 54.67  ? 37  PRO C N   1 
ATOM   4643 C CA  . PRO C 3 37  ? 196.490 231.251 324.903 1.00 49.28  ? 37  PRO C CA  1 
ATOM   4644 C C   . PRO C 3 37  ? 195.655 232.409 325.428 1.00 53.75  ? 37  PRO C C   1 
ATOM   4645 O O   . PRO C 3 37  ? 195.921 232.958 326.498 1.00 54.29  ? 37  PRO C O   1 
ATOM   4646 C CB  . PRO C 3 37  ? 196.168 229.948 325.640 1.00 42.45  ? 37  PRO C CB  1 
ATOM   4647 C CG  . PRO C 3 37  ? 197.452 229.224 325.696 1.00 47.43  ? 37  PRO C CG  1 
ATOM   4648 C CD  . PRO C 3 37  ? 198.512 230.273 325.835 1.00 54.90  ? 37  PRO C CD  1 
ATOM   4649 N N   . GLY C 3 38  ? 194.637 232.776 324.655 1.00 55.26  ? 38  GLY C N   1 
ATOM   4650 C CA  . GLY C 3 38  ? 193.675 233.769 325.088 1.00 54.23  ? 38  GLY C CA  1 
ATOM   4651 C C   . GLY C 3 38  ? 194.084 235.199 324.809 1.00 53.33  ? 38  GLY C C   1 
ATOM   4652 O O   . GLY C 3 38  ? 194.155 236.014 325.732 1.00 52.64  ? 38  GLY C O   1 
ATOM   4653 N N   . GLU C 3 39  ? 194.348 235.522 323.546 1.00 50.43  ? 39  GLU C N   1 
ATOM   4654 C CA  . GLU C 3 39  ? 194.663 236.888 323.151 1.00 49.82  ? 39  GLU C CA  1 
ATOM   4655 C C   . GLU C 3 39  ? 193.372 237.603 322.777 1.00 48.91  ? 39  GLU C C   1 
ATOM   4656 O O   . GLU C 3 39  ? 192.636 237.145 321.897 1.00 49.70  ? 39  GLU C O   1 
ATOM   4657 C CB  . GLU C 3 39  ? 195.641 236.912 321.978 1.00 57.30  ? 39  GLU C CB  1 
ATOM   4658 C CG  . GLU C 3 39  ? 196.151 238.306 321.638 1.00 60.07  ? 39  GLU C CG  1 
ATOM   4659 C CD  . GLU C 3 39  ? 196.996 238.333 320.383 1.00 60.47  ? 39  GLU C CD  1 
ATOM   4660 O OE1 . GLU C 3 39  ? 197.277 237.251 319.829 1.00 63.88  ? 39  GLU C OE1 1 
ATOM   4661 O OE2 . GLU C 3 39  ? 197.378 239.438 319.949 1.00 54.40  ? 39  GLU C OE2 1 
ATOM   4662 N N   . VAL C 3 40  ? 193.104 238.723 323.439 1.00 57.10  ? 40  VAL C N   1 
ATOM   4663 C CA  . VAL C 3 40  ? 191.916 239.527 323.186 1.00 58.41  ? 40  VAL C CA  1 
ATOM   4664 C C   . VAL C 3 40  ? 192.318 240.691 322.294 1.00 58.72  ? 40  VAL C C   1 
ATOM   4665 O O   . VAL C 3 40  ? 193.204 241.478 322.649 1.00 57.71  ? 40  VAL C O   1 
ATOM   4666 C CB  . VAL C 3 40  ? 191.288 240.027 324.494 1.00 51.19  ? 40  VAL C CB  1 
ATOM   4667 C CG1 . VAL C 3 40  ? 190.117 240.942 324.202 1.00 55.79  ? 40  VAL C CG1 1 
ATOM   4668 C CG2 . VAL C 3 40  ? 190.847 238.854 325.347 1.00 55.54  ? 40  VAL C CG2 1 
ATOM   4669 N N   . LYS C 3 41  ? 191.669 240.804 321.138 1.00 56.38  ? 41  LYS C N   1 
ATOM   4670 C CA  . LYS C 3 41  ? 191.969 241.853 320.173 1.00 57.93  ? 41  LYS C CA  1 
ATOM   4671 C C   . LYS C 3 41  ? 190.892 242.928 320.117 1.00 57.67  ? 41  LYS C C   1 
ATOM   4672 O O   . LYS C 3 41  ? 190.931 243.781 319.226 1.00 63.12  ? 41  LYS C O   1 
ATOM   4673 C CB  . LYS C 3 41  ? 192.176 241.241 318.787 1.00 58.93  ? 41  LYS C CB  1 
ATOM   4674 C CG  . LYS C 3 41  ? 193.481 240.474 318.655 1.00 63.70  ? 41  LYS C CG  1 
ATOM   4675 C CD  . LYS C 3 41  ? 193.655 239.884 317.265 1.00 63.60  ? 41  LYS C CD  1 
ATOM   4676 C CE  . LYS C 3 41  ? 192.866 238.595 317.094 1.00 66.71  ? 41  LYS C CE  1 
ATOM   4677 N NZ  . LYS C 3 41  ? 193.416 237.484 317.918 1.00 63.36  ? 41  LYS C NZ  1 
ATOM   4678 N N   . ASN C 3 42  ? 189.934 242.913 321.041 1.00 56.18  ? 42  ASN C N   1 
ATOM   4679 C CA  . ASN C 3 42  ? 188.908 243.944 321.087 1.00 56.15  ? 42  ASN C CA  1 
ATOM   4680 C C   . ASN C 3 42  ? 188.134 243.805 322.387 1.00 54.30  ? 42  ASN C C   1 
ATOM   4681 O O   . ASN C 3 42  ? 187.882 242.688 322.842 1.00 62.33  ? 42  ASN C O   1 
ATOM   4682 C CB  . ASN C 3 42  ? 187.958 243.837 319.889 1.00 53.60  ? 42  ASN C CB  1 
ATOM   4683 C CG  . ASN C 3 42  ? 187.253 245.141 319.589 1.00 54.34  ? 42  ASN C CG  1 
ATOM   4684 O OD1 . ASN C 3 42  ? 186.901 245.892 320.497 1.00 54.95  ? 42  ASN C OD1 1 
ATOM   4685 N ND2 . ASN C 3 42  ? 187.053 245.423 318.309 1.00 58.45  ? 42  ASN C ND2 1 
ATOM   4686 N N   . MET C 3 43  ? 187.763 244.941 322.980 1.00 50.15  ? 43  MET C N   1 
ATOM   4687 C CA  . MET C 3 43  ? 187.020 244.901 324.234 1.00 51.83  ? 43  MET C CA  1 
ATOM   4688 C C   . MET C 3 43  ? 185.630 244.312 324.044 1.00 57.95  ? 43  MET C C   1 
ATOM   4689 O O   . MET C 3 43  ? 185.073 243.730 324.981 1.00 61.43  ? 43  MET C O   1 
ATOM   4690 C CB  . MET C 3 43  ? 186.916 246.301 324.835 1.00 51.88  ? 43  MET C CB  1 
ATOM   4691 C CG  . MET C 3 43  ? 188.237 246.872 325.322 1.00 61.29  ? 43  MET C CG  1 
ATOM   4692 S SD  . MET C 3 43  ? 189.057 245.844 326.553 1.00 71.21  ? 43  MET C SD  1 
ATOM   4693 C CE  . MET C 3 43  ? 187.779 245.712 327.798 1.00 59.24  ? 43  MET C CE  1 
ATOM   4694 N N   . MET C 3 44  ? 185.054 244.449 322.849 1.00 50.15  ? 44  MET C N   1 
ATOM   4695 C CA  . MET C 3 44  ? 183.750 243.848 322.599 1.00 48.69  ? 44  MET C CA  1 
ATOM   4696 C C   . MET C 3 44  ? 183.786 242.342 322.803 1.00 56.48  ? 44  MET C C   1 
ATOM   4697 O O   . MET C 3 44  ? 182.787 241.751 323.226 1.00 60.80  ? 44  MET C O   1 
ATOM   4698 C CB  . MET C 3 44  ? 183.280 244.182 321.186 1.00 54.22  ? 44  MET C CB  1 
ATOM   4699 C CG  . MET C 3 44  ? 182.859 245.629 320.995 1.00 57.38  ? 44  MET C CG  1 
ATOM   4700 S SD  . MET C 3 44  ? 181.485 246.117 322.053 1.00 57.85  ? 44  MET C SD  1 
ATOM   4701 C CE  . MET C 3 44  ? 182.351 246.885 323.417 1.00 52.80  ? 44  MET C CE  1 
ATOM   4702 N N   . GLU C 3 45  ? 184.923 241.704 322.520 1.00 61.02  ? 45  GLU C N   1 
ATOM   4703 C CA  . GLU C 3 45  ? 185.032 240.270 322.755 1.00 55.08  ? 45  GLU C CA  1 
ATOM   4704 C C   . GLU C 3 45  ? 184.745 239.921 324.209 1.00 53.90  ? 45  GLU C C   1 
ATOM   4705 O O   . GLU C 3 45  ? 184.252 238.825 324.497 1.00 59.82  ? 45  GLU C O   1 
ATOM   4706 C CB  . GLU C 3 45  ? 186.422 239.776 322.359 1.00 61.41  ? 45  GLU C CB  1 
ATOM   4707 C CG  . GLU C 3 45  ? 186.769 240.002 320.897 1.00 65.78  ? 45  GLU C CG  1 
ATOM   4708 C CD  . GLU C 3 45  ? 188.088 239.362 320.506 1.00 72.44  ? 45  GLU C CD  1 
ATOM   4709 O OE1 . GLU C 3 45  ? 188.609 238.542 321.291 1.00 69.18  ? 45  GLU C OE1 1 
ATOM   4710 O OE2 . GLU C 3 45  ? 188.606 239.677 319.414 1.00 69.99  ? 45  GLU C OE2 1 
ATOM   4711 N N   . LEU C 3 46  ? 185.051 240.828 325.138 1.00 46.98  ? 46  LEU C N   1 
ATOM   4712 C CA  . LEU C 3 46  ? 184.713 240.600 326.537 1.00 49.41  ? 46  LEU C CA  1 
ATOM   4713 C C   . LEU C 3 46  ? 183.241 240.864 326.821 1.00 52.39  ? 46  LEU C C   1 
ATOM   4714 O O   . LEU C 3 46  ? 182.652 240.200 327.680 1.00 54.95  ? 46  LEU C O   1 
ATOM   4715 C CB  . LEU C 3 46  ? 185.574 241.480 327.441 1.00 54.26  ? 46  LEU C CB  1 
ATOM   4716 C CG  . LEU C 3 46  ? 187.087 241.343 327.279 1.00 53.65  ? 46  LEU C CG  1 
ATOM   4717 C CD1 . LEU C 3 46  ? 187.800 242.025 328.434 1.00 49.74  ? 46  LEU C CD1 1 
ATOM   4718 C CD2 . LEU C 3 46  ? 187.499 239.885 327.176 1.00 55.92  ? 46  LEU C CD2 1 
ATOM   4719 N N   . ALA C 3 47  ? 182.635 241.827 326.124 1.00 61.29  ? 47  ALA C N   1 
ATOM   4720 C CA  . ALA C 3 47  ? 181.226 242.130 326.341 1.00 57.47  ? 47  ALA C CA  1 
ATOM   4721 C C   . ALA C 3 47  ? 180.314 241.000 325.889 1.00 53.10  ? 47  ALA C C   1 
ATOM   4722 O O   . ALA C 3 47  ? 179.144 240.974 326.281 1.00 58.29  ? 47  ALA C O   1 
ATOM   4723 C CB  . ALA C 3 47  ? 180.846 243.417 325.610 1.00 51.77  ? 47  ALA C CB  1 
ATOM   4724 N N   . GLU C 3 48  ? 180.816 240.070 325.081 1.00 52.55  ? 48  GLU C N   1 
ATOM   4725 C CA  . GLU C 3 48  ? 180.009 238.994 324.529 1.00 57.23  ? 48  GLU C CA  1 
ATOM   4726 C C   . GLU C 3 48  ? 180.056 237.724 325.368 1.00 61.45  ? 48  GLU C C   1 
ATOM   4727 O O   . GLU C 3 48  ? 179.550 236.688 324.925 1.00 60.89  ? 48  GLU C O   1 
ATOM   4728 C CB  . GLU C 3 48  ? 180.459 238.683 323.101 1.00 60.17  ? 48  GLU C CB  1 
ATOM   4729 C CG  . GLU C 3 48  ? 180.313 239.853 322.150 1.00 63.49  ? 48  GLU C CG  1 
ATOM   4730 C CD  . GLU C 3 48  ? 180.659 239.491 320.724 1.00 69.13  ? 48  GLU C CD  1 
ATOM   4731 O OE1 . GLU C 3 48  ? 180.902 238.296 320.455 1.00 67.12  ? 48  GLU C OE1 1 
ATOM   4732 O OE2 . GLU C 3 48  ? 180.687 240.401 319.870 1.00 66.90  ? 48  GLU C OE2 1 
ATOM   4733 N N   . ILE C 3 49  ? 180.647 237.774 326.556 1.00 56.78  ? 49  ILE C N   1 
ATOM   4734 C CA  . ILE C 3 49  ? 180.731 236.620 327.442 1.00 51.28  ? 49  ILE C CA  1 
ATOM   4735 C C   . ILE C 3 49  ? 179.678 236.783 328.527 1.00 57.59  ? 49  ILE C C   1 
ATOM   4736 O O   . ILE C 3 49  ? 179.646 237.802 329.227 1.00 53.43  ? 49  ILE C O   1 
ATOM   4737 C CB  . ILE C 3 49  ? 182.135 236.477 328.047 1.00 46.45  ? 49  ILE C CB  1 
ATOM   4738 C CG1 . ILE C 3 49  ? 183.164 236.250 326.936 1.00 48.94  ? 49  ILE C CG1 1 
ATOM   4739 C CG2 . ILE C 3 49  ? 182.157 235.332 329.047 1.00 52.92  ? 49  ILE C CG2 1 
ATOM   4740 C CD1 . ILE C 3 49  ? 184.599 236.250 327.411 1.00 47.43  ? 49  ILE C CD1 1 
ATOM   4741 N N   . ASP C 3 50  ? 178.820 235.776 328.671 1.00 62.37  ? 50  ASP C N   1 
ATOM   4742 C CA  . ASP C 3 50  ? 177.715 235.860 329.614 1.00 62.62  ? 50  ASP C CA  1 
ATOM   4743 C C   . ASP C 3 50  ? 178.227 236.023 331.039 1.00 65.81  ? 50  ASP C C   1 
ATOM   4744 O O   . ASP C 3 50  ? 179.264 235.475 331.420 1.00 68.25  ? 50  ASP C O   1 
ATOM   4745 C CB  . ASP C 3 50  ? 176.841 234.611 329.517 1.00 62.45  ? 50  ASP C CB  1 
ATOM   4746 C CG  . ASP C 3 50  ? 176.098 234.522 328.202 1.00 68.00  ? 50  ASP C CG  1 
ATOM   4747 O OD1 . ASP C 3 50  ? 176.388 235.333 327.300 1.00 69.64  ? 50  ASP C OD1 1 
ATOM   4748 O OD2 . ASP C 3 50  ? 175.219 233.645 328.071 1.00 63.43  ? 50  ASP C OD2 1 
ATOM   4749 N N   . THR C 3 51  ? 177.483 236.792 331.829 1.00 57.70  ? 51  THR C N   1 
ATOM   4750 C CA  . THR C 3 51  ? 177.822 237.033 333.222 1.00 54.16  ? 51  THR C CA  1 
ATOM   4751 C C   . THR C 3 51  ? 176.533 237.187 334.012 1.00 51.72  ? 51  THR C C   1 
ATOM   4752 O O   . THR C 3 51  ? 175.579 237.804 333.535 1.00 56.81  ? 51  THR C O   1 
ATOM   4753 C CB  . THR C 3 51  ? 178.692 238.281 333.373 1.00 51.58  ? 51  THR C CB  1 
ATOM   4754 O OG1 . THR C 3 51  ? 178.041 239.394 332.750 1.00 50.16  ? 51  THR C OG1 1 
ATOM   4755 C CG2 . THR C 3 51  ? 180.044 238.063 332.725 1.00 49.61  ? 51  THR C CG2 1 
ATOM   4756 N N   . MET C 3 52  ? 176.512 236.631 335.219 1.00 47.73  ? 52  MET C N   1 
ATOM   4757 C CA  . MET C 3 52  ? 175.284 236.610 335.999 1.00 49.87  ? 52  MET C CA  1 
ATOM   4758 C C   . MET C 3 52  ? 174.853 238.022 336.367 1.00 52.23  ? 52  MET C C   1 
ATOM   4759 O O   . MET C 3 52  ? 175.669 238.860 336.758 1.00 50.63  ? 52  MET C O   1 
ATOM   4760 C CB  . MET C 3 52  ? 175.461 235.776 337.265 1.00 50.56  ? 52  MET C CB  1 
ATOM   4761 C CG  . MET C 3 52  ? 175.383 234.279 337.039 1.00 48.40  ? 52  MET C CG  1 
ATOM   4762 S SD  . MET C 3 52  ? 175.070 233.367 338.559 1.00 62.79  ? 52  MET C SD  1 
ATOM   4763 C CE  . MET C 3 52  ? 176.419 233.932 339.588 1.00 48.38  ? 52  MET C CE  1 
ATOM   4764 N N   . ILE C 3 53  ? 173.555 238.275 336.248 1.00 58.75  ? 53  ILE C N   1 
ATOM   4765 C CA  . ILE C 3 53  ? 172.971 239.568 336.583 1.00 53.39  ? 53  ILE C CA  1 
ATOM   4766 C C   . ILE C 3 53  ? 172.558 239.523 338.051 1.00 56.03  ? 53  ILE C C   1 
ATOM   4767 O O   . ILE C 3 53  ? 171.685 238.717 338.407 1.00 64.49  ? 53  ILE C O   1 
ATOM   4768 C CB  . ILE C 3 53  ? 171.763 239.884 335.694 1.00 51.04  ? 53  ILE C CB  1 
ATOM   4769 C CG1 . ILE C 3 53  ? 172.080 239.621 334.221 1.00 52.29  ? 53  ILE C CG1 1 
ATOM   4770 C CG2 . ILE C 3 53  ? 171.341 241.328 335.874 1.00 58.31  ? 53  ILE C CG2 1 
ATOM   4771 C CD1 . ILE C 3 53  ? 170.863 239.682 333.330 1.00 55.70  ? 53  ILE C CD1 1 
ATOM   4772 N N   . PRO C 3 54  ? 173.131 240.356 338.920 1.00 50.71  ? 54  PRO C N   1 
ATOM   4773 C CA  . PRO C 3 54  ? 172.698 240.345 340.322 1.00 53.16  ? 54  PRO C CA  1 
ATOM   4774 C C   . PRO C 3 54  ? 171.295 240.902 340.468 1.00 51.99  ? 54  PRO C C   1 
ATOM   4775 O O   . PRO C 3 54  ? 171.117 242.077 340.796 1.00 58.97  ? 54  PRO C O   1 
ATOM   4776 C CB  . PRO C 3 54  ? 173.738 241.229 341.014 1.00 53.48  ? 54  PRO C CB  1 
ATOM   4777 C CG  . PRO C 3 54  ? 174.164 242.172 339.964 1.00 52.44  ? 54  PRO C CG  1 
ATOM   4778 C CD  . PRO C 3 54  ? 174.156 241.385 338.680 1.00 50.89  ? 54  PRO C CD  1 
ATOM   4779 N N   . PHE C 3 55  ? 170.289 240.071 340.199 1.00 60.49  ? 55  PHE C N   1 
ATOM   4780 C CA  . PHE C 3 55  ? 168.915 240.557 340.129 1.00 58.41  ? 55  PHE C CA  1 
ATOM   4781 C C   . PHE C 3 55  ? 168.448 241.134 341.458 1.00 61.61  ? 55  PHE C C   1 
ATOM   4782 O O   . PHE C 3 55  ? 167.989 242.279 341.528 1.00 67.86  ? 55  PHE C O   1 
ATOM   4783 C CB  . PHE C 3 55  ? 167.990 239.420 339.697 1.00 58.22  ? 55  PHE C CB  1 
ATOM   4784 C CG  . PHE C 3 55  ? 167.986 239.167 338.224 1.00 59.26  ? 55  PHE C CG  1 
ATOM   4785 C CD1 . PHE C 3 55  ? 167.845 240.209 337.329 1.00 56.43  ? 55  PHE C CD1 1 
ATOM   4786 C CD2 . PHE C 3 55  ? 168.122 237.884 337.733 1.00 60.09  ? 55  PHE C CD2 1 
ATOM   4787 C CE1 . PHE C 3 55  ? 167.841 239.977 335.979 1.00 59.64  ? 55  PHE C CE1 1 
ATOM   4788 C CE2 . PHE C 3 55  ? 168.115 237.646 336.383 1.00 64.48  ? 55  PHE C CE2 1 
ATOM   4789 C CZ  . PHE C 3 55  ? 167.977 238.693 335.503 1.00 64.72  ? 55  PHE C CZ  1 
ATOM   4790 N N   . ASP C 3 56  ? 168.546 240.346 342.528 1.00 70.24  ? 56  ASP C N   1 
ATOM   4791 C CA  . ASP C 3 56  ? 167.904 240.696 343.795 1.00 73.29  ? 56  ASP C CA  1 
ATOM   4792 C C   . ASP C 3 56  ? 168.847 241.550 344.645 1.00 73.08  ? 56  ASP C C   1 
ATOM   4793 O O   . ASP C 3 56  ? 169.392 241.122 345.663 1.00 73.06  ? 56  ASP C O   1 
ATOM   4794 C CB  . ASP C 3 56  ? 167.474 239.439 344.538 1.00 74.56  ? 56  ASP C CB  1 
ATOM   4795 C CG  . ASP C 3 56  ? 166.191 239.639 345.319 1.00 79.10  ? 56  ASP C CG  1 
ATOM   4796 O OD1 . ASP C 3 56  ? 165.901 240.792 345.700 1.00 78.49  ? 56  ASP C OD1 1 
ATOM   4797 O OD2 . ASP C 3 56  ? 165.474 238.643 345.557 1.00 75.91  ? 56  ASP C OD2 1 
ATOM   4798 N N   . LEU C 3 57  ? 169.039 242.792 344.200 1.00 68.09  ? 57  LEU C N   1 
ATOM   4799 C CA  . LEU C 3 57  ? 169.813 243.779 344.954 1.00 68.31  ? 57  LEU C CA  1 
ATOM   4800 C C   . LEU C 3 57  ? 168.900 244.475 345.967 1.00 72.07  ? 57  LEU C C   1 
ATOM   4801 O O   . LEU C 3 57  ? 168.676 245.685 345.930 1.00 76.35  ? 57  LEU C O   1 
ATOM   4802 C CB  . LEU C 3 57  ? 170.444 244.795 344.014 1.00 64.97  ? 57  LEU C CB  1 
ATOM   4803 C CG  . LEU C 3 57  ? 171.379 244.274 342.929 1.00 66.40  ? 57  LEU C CG  1 
ATOM   4804 C CD1 . LEU C 3 57  ? 171.870 245.413 342.054 1.00 64.90  ? 57  LEU C CD1 1 
ATOM   4805 C CD2 . LEU C 3 57  ? 172.548 243.530 343.544 1.00 72.09  ? 57  LEU C CD2 1 
ATOM   4806 N N   . SER C 3 58  ? 168.376 243.684 346.901 1.00 74.36  ? 58  SER C N   1 
ATOM   4807 C CA  . SER C 3 58  ? 167.376 244.162 347.851 1.00 76.05  ? 58  SER C CA  1 
ATOM   4808 C C   . SER C 3 58  ? 167.804 243.811 349.266 1.00 75.54  ? 58  SER C C   1 
ATOM   4809 O O   . SER C 3 58  ? 167.929 242.630 349.602 1.00 79.60  ? 58  SER C O   1 
ATOM   4810 C CB  . SER C 3 58  ? 166.004 243.557 347.552 1.00 79.20  ? 58  SER C CB  1 
ATOM   4811 O OG  . SER C 3 58  ? 166.001 242.160 347.773 1.00 81.17  ? 58  SER C OG  1 
ATOM   4812 N N   . ALA C 3 59  ? 168.017 244.833 350.094 1.00 73.79  ? 59  ALA C N   1 
ATOM   4813 C CA  . ALA C 3 59  ? 168.180 244.636 351.527 1.00 76.66  ? 59  ALA C CA  1 
ATOM   4814 C C   . ALA C 3 59  ? 169.246 243.589 351.834 1.00 79.39  ? 59  ALA C C   1 
ATOM   4815 O O   . ALA C 3 59  ? 170.431 243.800 351.556 1.00 75.98  ? 59  ALA C O   1 
ATOM   4816 C CB  . ALA C 3 59  ? 166.836 244.245 352.148 1.00 76.16  ? 59  ALA C CB  1 
ATOM   4817 N N   . THR C 3 60  ? 168.830 242.457 352.409 1.00 87.20  ? 60  THR C N   1 
ATOM   4818 C CA  . THR C 3 60  ? 169.784 241.448 352.860 1.00 86.08  ? 60  THR C CA  1 
ATOM   4819 C C   . THR C 3 60  ? 170.638 240.936 351.705 1.00 88.31  ? 60  THR C C   1 
ATOM   4820 O O   . THR C 3 60  ? 171.872 240.932 351.778 1.00 88.54  ? 60  THR C O   1 
ATOM   4821 C CB  . THR C 3 60  ? 169.037 240.286 353.516 1.00 87.98  ? 60  THR C CB  1 
ATOM   4822 O OG1 . THR C 3 60  ? 168.138 239.695 352.567 1.00 88.61  ? 60  THR C OG1 1 
ATOM   4823 C CG2 . THR C 3 60  ? 168.236 240.749 354.739 1.00 86.72  ? 60  THR C CG2 1 
ATOM   4824 N N   . LYS C 3 61  ? 169.989 240.487 350.627 1.00 84.71  ? 61  LYS C N   1 
ATOM   4825 C CA  . LYS C 3 61  ? 170.700 239.797 349.555 1.00 82.61  ? 61  LYS C CA  1 
ATOM   4826 C C   . LYS C 3 61  ? 171.831 240.633 348.977 1.00 82.85  ? 61  LYS C C   1 
ATOM   4827 O O   . LYS C 3 61  ? 172.864 240.082 348.579 1.00 81.73  ? 61  LYS C O   1 
ATOM   4828 C CB  . LYS C 3 61  ? 169.724 239.405 348.443 1.00 83.74  ? 61  LYS C CB  1 
ATOM   4829 C CG  . LYS C 3 61  ? 168.725 238.335 348.844 1.00 83.96  ? 61  LYS C CG  1 
ATOM   4830 C CD  . LYS C 3 61  ? 167.955 237.851 347.634 1.00 86.83  ? 61  LYS C CD  1 
ATOM   4831 C CE  . LYS C 3 61  ? 167.076 236.660 347.963 1.00 85.19  ? 61  LYS C CE  1 
ATOM   4832 N NZ  . LYS C 3 61  ? 165.991 237.023 348.911 1.00 87.85  ? 61  LYS C NZ  1 
ATOM   4833 N N   . LYS C 3 62  ? 171.658 241.952 348.919 1.00 74.38  ? 62  LYS C N   1 
ATOM   4834 C CA  . LYS C 3 62  ? 172.657 242.820 348.309 1.00 70.36  ? 62  LYS C CA  1 
ATOM   4835 C C   . LYS C 3 62  ? 174.043 242.530 348.871 1.00 73.47  ? 62  LYS C C   1 
ATOM   4836 O O   . LYS C 3 62  ? 174.225 242.396 350.084 1.00 75.07  ? 62  LYS C O   1 
ATOM   4837 C CB  . LYS C 3 62  ? 172.280 244.283 348.547 1.00 68.70  ? 62  LYS C CB  1 
ATOM   4838 C CG  . LYS C 3 62  ? 173.388 245.290 348.275 1.00 71.25  ? 62  LYS C CG  1 
ATOM   4839 C CD  . LYS C 3 62  ? 172.886 246.723 348.415 1.00 71.25  ? 62  LYS C CD  1 
ATOM   4840 C CE  . LYS C 3 62  ? 172.441 247.040 349.839 1.00 72.35  ? 62  LYS C CE  1 
ATOM   4841 N NZ  . LYS C 3 62  ? 173.383 247.955 350.535 1.00 72.51  ? 62  LYS C NZ  1 
ATOM   4842 N N   . ASN C 3 63  ? 175.021 242.426 347.970 1.00 70.93  ? 63  ASN C N   1 
ATOM   4843 C CA  . ASN C 3 63  ? 176.407 242.137 348.336 1.00 65.86  ? 63  ASN C CA  1 
ATOM   4844 C C   . ASN C 3 63  ? 176.528 240.782 349.031 1.00 69.31  ? 63  ASN C C   1 
ATOM   4845 O O   . ASN C 3 63  ? 177.216 240.640 350.043 1.00 69.88  ? 63  ASN C O   1 
ATOM   4846 C CB  . ASN C 3 63  ? 176.989 243.256 349.201 1.00 64.49  ? 63  ASN C CB  1 
ATOM   4847 C CG  . ASN C 3 63  ? 177.157 244.546 348.431 1.00 69.58  ? 63  ASN C CG  1 
ATOM   4848 O OD1 . ASN C 3 63  ? 177.525 244.533 347.257 1.00 70.73  ? 63  ASN C OD1 1 
ATOM   4849 N ND2 . ASN C 3 63  ? 176.882 245.667 349.081 1.00 72.09  ? 63  ASN C ND2 1 
ATOM   4850 N N   . THR C 3 64  ? 175.847 239.779 348.483 1.00 71.31  ? 64  THR C N   1 
ATOM   4851 C CA  . THR C 3 64  ? 175.966 238.406 348.951 1.00 71.59  ? 64  THR C CA  1 
ATOM   4852 C C   . THR C 3 64  ? 175.546 237.494 347.810 1.00 71.56  ? 64  THR C C   1 
ATOM   4853 O O   . THR C 3 64  ? 174.840 237.914 346.892 1.00 74.56  ? 64  THR C O   1 
ATOM   4854 C CB  . THR C 3 64  ? 175.112 238.158 350.201 1.00 69.82  ? 64  THR C CB  1 
ATOM   4855 O OG1 . THR C 3 64  ? 175.516 239.057 351.239 1.00 70.48  ? 64  THR C OG1 1 
ATOM   4856 C CG2 . THR C 3 64  ? 175.257 236.721 350.695 1.00 69.47  ? 64  THR C CG2 1 
ATOM   4857 N N   . MET C 3 65  ? 175.994 236.238 347.874 1.00 66.10  ? 65  MET C N   1 
ATOM   4858 C CA  . MET C 3 65  ? 175.637 235.275 346.837 1.00 61.02  ? 65  MET C CA  1 
ATOM   4859 C C   . MET C 3 65  ? 174.146 235.302 346.536 1.00 69.02  ? 65  MET C C   1 
ATOM   4860 O O   . MET C 3 65  ? 173.742 235.179 345.373 1.00 72.46  ? 65  MET C O   1 
ATOM   4861 C CB  . MET C 3 65  ? 176.055 233.871 347.271 1.00 68.10  ? 65  MET C CB  1 
ATOM   4862 C CG  . MET C 3 65  ? 177.548 233.713 347.506 1.00 74.19  ? 65  MET C CG  1 
ATOM   4863 S SD  . MET C 3 65  ? 178.488 233.701 345.971 1.00 81.45  ? 65  MET C SD  1 
ATOM   4864 C CE  . MET C 3 65  ? 177.983 232.126 345.284 1.00 70.60  ? 65  MET C CE  1 
ATOM   4865 N N   . GLU C 3 66  ? 173.316 235.505 347.561 1.00 75.87  ? 66  GLU C N   1 
ATOM   4866 C CA  . GLU C 3 66  ? 171.871 235.438 347.376 1.00 72.82  ? 66  GLU C CA  1 
ATOM   4867 C C   . GLU C 3 66  ? 171.393 236.422 346.319 1.00 72.36  ? 66  GLU C C   1 
ATOM   4868 O O   . GLU C 3 66  ? 170.346 236.206 345.700 1.00 75.99  ? 66  GLU C O   1 
ATOM   4869 C CB  . GLU C 3 66  ? 171.160 235.710 348.701 1.00 74.40  ? 66  GLU C CB  1 
ATOM   4870 C CG  . GLU C 3 66  ? 171.624 234.840 349.858 1.00 80.47  ? 66  GLU C CG  1 
ATOM   4871 C CD  . GLU C 3 66  ? 171.020 235.263 351.181 1.00 82.28  ? 66  GLU C CD  1 
ATOM   4872 O OE1 . GLU C 3 66  ? 169.917 235.850 351.171 1.00 81.34  ? 66  GLU C OE1 1 
ATOM   4873 O OE2 . GLU C 3 66  ? 171.650 235.017 352.231 1.00 78.45  ? 66  GLU C OE2 1 
ATOM   4874 N N   . MET C 3 67  ? 172.141 237.503 346.094 1.00 66.60  ? 67  MET C N   1 
ATOM   4875 C CA  . MET C 3 67  ? 171.710 238.514 345.138 1.00 65.55  ? 67  MET C CA  1 
ATOM   4876 C C   . MET C 3 67  ? 171.653 237.978 343.717 1.00 67.35  ? 67  MET C C   1 
ATOM   4877 O O   . MET C 3 67  ? 171.007 238.597 342.865 1.00 73.74  ? 67  MET C O   1 
ATOM   4878 C CB  . MET C 3 67  ? 172.645 239.721 345.194 1.00 63.71  ? 67  MET C CB  1 
ATOM   4879 C CG  . MET C 3 67  ? 174.000 239.484 344.562 1.00 67.41  ? 67  MET C CG  1 
ATOM   4880 S SD  . MET C 3 67  ? 175.248 240.614 345.201 1.00 69.42  ? 67  MET C SD  1 
ATOM   4881 C CE  . MET C 3 67  ? 176.714 240.020 344.366 1.00 60.76  ? 67  MET C CE  1 
ATOM   4882 N N   . TYR C 3 68  ? 172.308 236.853 343.435 1.00 51.72  ? 68  TYR C N   1 
ATOM   4883 C CA  . TYR C 3 68  ? 172.288 236.289 342.093 1.00 46.78  ? 68  TYR C CA  1 
ATOM   4884 C C   . TYR C 3 68  ? 171.134 235.323 341.861 1.00 57.12  ? 68  TYR C C   1 
ATOM   4885 O O   . TYR C 3 68  ? 170.920 234.908 340.718 1.00 58.10  ? 68  TYR C O   1 
ATOM   4886 C CB  . TYR C 3 68  ? 173.607 235.569 341.802 1.00 49.96  ? 68  TYR C CB  1 
ATOM   4887 C CG  . TYR C 3 68  ? 174.779 236.501 341.610 1.00 54.65  ? 68  TYR C CG  1 
ATOM   4888 C CD1 . TYR C 3 68  ? 174.874 237.300 340.482 1.00 57.44  ? 68  TYR C CD1 1 
ATOM   4889 C CD2 . TYR C 3 68  ? 175.792 236.577 342.551 1.00 55.46  ? 68  TYR C CD2 1 
ATOM   4890 C CE1 . TYR C 3 68  ? 175.940 238.151 340.301 1.00 55.40  ? 68  TYR C CE1 1 
ATOM   4891 C CE2 . TYR C 3 68  ? 176.863 237.425 342.376 1.00 52.42  ? 68  TYR C CE2 1 
ATOM   4892 C CZ  . TYR C 3 68  ? 176.931 238.209 341.250 1.00 50.01  ? 68  TYR C CZ  1 
ATOM   4893 O OH  . TYR C 3 68  ? 177.995 239.057 341.070 1.00 57.04  ? 68  TYR C OH  1 
ATOM   4894 N N   . ARG C 3 69  ? 170.386 234.963 342.900 1.00 63.32  ? 69  ARG C N   1 
ATOM   4895 C CA  . ARG C 3 69  ? 169.311 233.987 342.790 1.00 56.97  ? 69  ARG C CA  1 
ATOM   4896 C C   . ARG C 3 69  ? 167.965 234.693 342.706 1.00 57.88  ? 69  ARG C C   1 
ATOM   4897 O O   . ARG C 3 69  ? 167.639 235.523 343.560 1.00 56.15  ? 69  ARG C O   1 
ATOM   4898 C CB  . ARG C 3 69  ? 169.310 233.030 343.983 1.00 53.55  ? 69  ARG C CB  1 
ATOM   4899 C CG  . ARG C 3 69  ? 170.463 232.045 344.015 1.00 54.06  ? 69  ARG C CG  1 
ATOM   4900 C CD  . ARG C 3 69  ? 171.748 232.697 344.478 1.00 58.35  ? 69  ARG C CD  1 
ATOM   4901 N NE  . ARG C 3 69  ? 172.753 231.710 344.853 1.00 60.47  ? 69  ARG C NE  1 
ATOM   4902 C CZ  . ARG C 3 69  ? 172.797 231.096 346.027 1.00 57.01  ? 69  ARG C CZ  1 
ATOM   4903 N NH1 . ARG C 3 69  ? 171.898 231.337 346.968 1.00 54.55  ? 69  ARG C NH1 1 
ATOM   4904 N NH2 . ARG C 3 69  ? 173.765 230.216 346.263 1.00 59.37  ? 69  ARG C NH2 1 
ATOM   4905 N N   . VAL C 3 70  ? 167.190 234.355 341.682 1.00 59.80  ? 70  VAL C N   1 
ATOM   4906 C CA  . VAL C 3 70  ? 165.792 234.753 341.580 1.00 56.01  ? 70  VAL C CA  1 
ATOM   4907 C C   . VAL C 3 70  ? 164.952 233.555 341.994 1.00 60.77  ? 70  VAL C C   1 
ATOM   4908 O O   . VAL C 3 70  ? 164.984 232.510 341.334 1.00 65.31  ? 70  VAL C O   1 
ATOM   4909 C CB  . VAL C 3 70  ? 165.438 235.213 340.159 1.00 57.07  ? 70  VAL C CB  1 
ATOM   4910 C CG1 . VAL C 3 70  ? 163.940 235.417 340.023 1.00 60.38  ? 70  VAL C CG1 1 
ATOM   4911 C CG2 . VAL C 3 70  ? 166.175 236.487 339.824 1.00 63.15  ? 70  VAL C CG2 1 
ATOM   4912 N N   . ARG C 3 71  ? 164.202 233.700 343.080 1.00 64.02  ? 71  ARG C N   1 
ATOM   4913 C CA  . ARG C 3 71  ? 163.485 232.579 343.672 1.00 68.06  ? 71  ARG C CA  1 
ATOM   4914 C C   . ARG C 3 71  ? 162.111 232.446 343.033 1.00 68.28  ? 71  ARG C C   1 
ATOM   4915 O O   . ARG C 3 71  ? 161.294 233.370 343.101 1.00 67.30  ? 71  ARG C O   1 
ATOM   4916 C CB  . ARG C 3 71  ? 163.355 232.756 345.183 1.00 68.52  ? 71  ARG C CB  1 
ATOM   4917 C CG  . ARG C 3 71  ? 162.419 231.752 345.837 1.00 63.98  ? 71  ARG C CG  1 
ATOM   4918 C CD  . ARG C 3 71  ? 162.958 231.269 347.171 1.00 70.07  ? 71  ARG C CD  1 
ATOM   4919 N NE  . ARG C 3 71  ? 164.157 230.455 347.005 1.00 75.99  ? 71  ARG C NE  1 
ATOM   4920 C CZ  . ARG C 3 71  ? 164.821 229.884 348.000 1.00 75.31  ? 71  ARG C CZ  1 
ATOM   4921 N NH1 . ARG C 3 71  ? 164.433 230.016 349.258 1.00 73.85  ? 71  ARG C NH1 1 
ATOM   4922 N NH2 . ARG C 3 71  ? 165.902 229.159 347.726 1.00 70.12  ? 71  ARG C NH2 1 
ATOM   4923 N N   . LEU C 3 72  ? 161.864 231.298 342.412 1.00 68.43  ? 72  LEU C N   1 
ATOM   4924 C CA  . LEU C 3 72  ? 160.543 230.938 341.927 1.00 68.66  ? 72  LEU C CA  1 
ATOM   4925 C C   . LEU C 3 72  ? 159.815 230.172 343.029 1.00 70.29  ? 72  LEU C C   1 
ATOM   4926 O O   . LEU C 3 72  ? 160.258 230.130 344.179 1.00 72.37  ? 72  LEU C O   1 
ATOM   4927 C CB  . LEU C 3 72  ? 160.649 230.122 340.643 1.00 70.43  ? 72  LEU C CB  1 
ATOM   4928 C CG  . LEU C 3 72  ? 161.498 230.724 339.526 1.00 65.51  ? 72  LEU C CG  1 
ATOM   4929 C CD1 . LEU C 3 72  ? 161.352 229.901 338.260 1.00 65.94  ? 72  LEU C CD1 1 
ATOM   4930 C CD2 . LEU C 3 72  ? 161.110 232.167 339.284 1.00 64.41  ? 72  LEU C CD2 1 
ATOM   4931 N N   . SER C 3 73  ? 158.689 229.554 342.694 1.00 73.05  ? 73  SER C N   1 
ATOM   4932 C CA  . SER C 3 73  ? 157.921 228.803 343.676 1.00 74.26  ? 73  SER C CA  1 
ATOM   4933 C C   . SER C 3 73  ? 156.939 227.901 342.942 1.00 76.05  ? 73  SER C C   1 
ATOM   4934 O O   . SER C 3 73  ? 156.896 227.863 341.710 1.00 76.07  ? 73  SER C O   1 
ATOM   4935 C CB  . SER C 3 73  ? 157.195 229.743 344.642 1.00 72.79  ? 73  SER C CB  1 
ATOM   4936 O OG  . SER C 3 73  ? 158.111 230.572 345.335 1.00 76.76  ? 73  SER C OG  1 
ATOM   4937 N N   . ASP C 3 74  ? 156.149 227.165 343.723 1.00 79.91  ? 74  ASP C N   1 
ATOM   4938 C CA  . ASP C 3 74  ? 155.074 226.325 343.216 1.00 79.38  ? 74  ASP C CA  1 
ATOM   4939 C C   . ASP C 3 74  ? 153.706 226.958 343.445 1.00 79.75  ? 74  ASP C C   1 
ATOM   4940 O O   . ASP C 3 74  ? 152.685 226.264 343.397 1.00 81.54  ? 74  ASP C O   1 
ATOM   4941 C CB  . ASP C 3 74  ? 155.147 224.947 343.875 1.00 82.66  ? 74  ASP C CB  1 
ATOM   4942 C CG  . ASP C 3 74  ? 154.154 223.963 343.291 1.00 89.19  ? 74  ASP C CG  1 
ATOM   4943 O OD1 . ASP C 3 74  ? 154.337 223.547 342.129 1.00 91.85  ? 74  ASP C OD1 1 
ATOM   4944 O OD2 . ASP C 3 74  ? 153.190 223.604 343.999 1.00 90.54  ? 74  ASP C OD2 1 
ATOM   4945 N N   . LYS C 3 75  ? 153.668 228.265 343.688 1.00 70.95  ? 75  LYS C N   1 
ATOM   4946 C CA  . LYS C 3 75  ? 152.426 228.944 344.003 1.00 72.83  ? 75  LYS C CA  1 
ATOM   4947 C C   . LYS C 3 75  ? 151.475 228.908 342.810 1.00 73.08  ? 75  LYS C C   1 
ATOM   4948 O O   . LYS C 3 75  ? 151.904 228.758 341.664 1.00 70.30  ? 75  LYS C O   1 
ATOM   4949 C CB  . LYS C 3 75  ? 152.706 230.391 344.402 1.00 72.78  ? 75  LYS C CB  1 
ATOM   4950 C CG  . LYS C 3 75  ? 153.430 231.196 343.330 1.00 70.78  ? 75  LYS C CG  1 
ATOM   4951 C CD  . LYS C 3 75  ? 153.755 232.605 343.798 1.00 69.49  ? 75  LYS C CD  1 
ATOM   4952 C CE  . LYS C 3 75  ? 152.502 233.450 343.958 1.00 69.81  ? 75  LYS C CE  1 
ATOM   4953 N NZ  . LYS C 3 75  ? 152.825 234.866 344.281 1.00 65.86  ? 75  LYS C NZ  1 
ATOM   4954 N N   . PRO C 3 76  ? 150.171 229.043 343.055 1.00 67.90  ? 76  PRO C N   1 
ATOM   4955 C CA  . PRO C 3 76  ? 149.218 229.078 341.941 1.00 65.43  ? 76  PRO C CA  1 
ATOM   4956 C C   . PRO C 3 76  ? 149.499 230.251 341.016 1.00 70.17  ? 76  PRO C C   1 
ATOM   4957 O O   . PRO C 3 76  ? 150.017 231.289 341.431 1.00 69.81  ? 76  PRO C O   1 
ATOM   4958 C CB  . PRO C 3 76  ? 147.859 229.216 342.636 1.00 67.81  ? 76  PRO C CB  1 
ATOM   4959 C CG  . PRO C 3 76  ? 148.167 229.738 343.996 1.00 65.77  ? 76  PRO C CG  1 
ATOM   4960 C CD  . PRO C 3 76  ? 149.497 229.167 344.358 1.00 65.70  ? 76  PRO C CD  1 
ATOM   4961 N N   . HIS C 3 77  ? 149.147 230.071 339.744 1.00 70.11  ? 77  HIS C N   1 
ATOM   4962 C CA  . HIS C 3 77  ? 149.524 231.029 338.714 1.00 71.18  ? 77  HIS C CA  1 
ATOM   4963 C C   . HIS C 3 77  ? 149.064 232.435 339.077 1.00 72.52  ? 77  HIS C C   1 
ATOM   4964 O O   . HIS C 3 77  ? 147.941 232.641 339.544 1.00 68.75  ? 77  HIS C O   1 
ATOM   4965 C CB  . HIS C 3 77  ? 148.925 230.618 337.369 1.00 66.61  ? 77  HIS C CB  1 
ATOM   4966 C CG  . HIS C 3 77  ? 149.153 231.616 336.279 1.00 69.92  ? 77  HIS C CG  1 
ATOM   4967 N ND1 . HIS C 3 77  ? 148.252 232.615 335.983 1.00 71.35  ? 77  HIS C ND1 1 
ATOM   4968 C CD2 . HIS C 3 77  ? 150.182 231.770 335.413 1.00 71.73  ? 77  HIS C CD2 1 
ATOM   4969 C CE1 . HIS C 3 77  ? 148.715 233.341 334.981 1.00 69.70  ? 77  HIS C CE1 1 
ATOM   4970 N NE2 . HIS C 3 77  ? 149.885 232.849 334.617 1.00 73.47  ? 77  HIS C NE2 1 
ATOM   4971 N N   . THR C 3 78  ? 149.953 233.403 338.859 1.00 78.20  ? 78  THR C N   1 
ATOM   4972 C CA  . THR C 3 78  ? 149.674 234.804 339.130 1.00 78.92  ? 78  THR C CA  1 
ATOM   4973 C C   . THR C 3 78  ? 150.290 235.653 338.027 1.00 79.69  ? 78  THR C C   1 
ATOM   4974 O O   . THR C 3 78  ? 151.252 235.250 337.369 1.00 76.20  ? 78  THR C O   1 
ATOM   4975 C CB  . THR C 3 78  ? 150.221 235.237 340.496 1.00 75.66  ? 78  THR C CB  1 
ATOM   4976 O OG1 . THR C 3 78  ? 149.953 236.630 340.703 1.00 74.74  ? 78  THR C OG1 1 
ATOM   4977 C CG2 . THR C 3 78  ? 151.722 234.994 340.575 1.00 70.56  ? 78  THR C CG2 1 
ATOM   4978 N N   . ASP C 3 79  ? 149.721 236.841 337.832 1.00 81.81  ? 79  ASP C N   1 
ATOM   4979 C CA  . ASP C 3 79  ? 150.196 237.764 336.810 1.00 80.22  ? 79  ASP C CA  1 
ATOM   4980 C C   . ASP C 3 79  ? 151.296 238.695 337.301 1.00 79.47  ? 79  ASP C C   1 
ATOM   4981 O O   . ASP C 3 79  ? 151.894 239.402 336.484 1.00 80.99  ? 79  ASP C O   1 
ATOM   4982 C CB  . ASP C 3 79  ? 149.032 238.604 336.276 1.00 81.84  ? 79  ASP C CB  1 
ATOM   4983 C CG  . ASP C 3 79  ? 148.239 237.887 335.204 1.00 87.35  ? 79  ASP C CG  1 
ATOM   4984 O OD1 . ASP C 3 79  ? 148.857 237.207 334.359 1.00 85.97  ? 79  ASP C OD1 1 
ATOM   4985 O OD2 . ASP C 3 79  ? 146.995 238.005 335.202 1.00 83.06  ? 79  ASP C OD2 1 
ATOM   4986 N N   . ASP C 3 80  ? 151.581 238.714 338.595 1.00 75.15  ? 80  ASP C N   1 
ATOM   4987 C CA  . ASP C 3 80  ? 152.620 239.593 339.106 1.00 71.70  ? 80  ASP C CA  1 
ATOM   4988 C C   . ASP C 3 80  ? 153.965 239.198 338.504 1.00 71.04  ? 80  ASP C C   1 
ATOM   4989 O O   . ASP C 3 80  ? 154.299 238.006 338.480 1.00 77.33  ? 80  ASP C O   1 
ATOM   4990 C CB  . ASP C 3 80  ? 152.679 239.518 340.629 1.00 76.80  ? 80  ASP C CB  1 
ATOM   4991 C CG  . ASP C 3 80  ? 151.338 239.794 341.276 1.00 79.68  ? 80  ASP C CG  1 
ATOM   4992 O OD1 . ASP C 3 80  ? 150.538 240.549 340.685 1.00 82.10  ? 80  ASP C OD1 1 
ATOM   4993 O OD2 . ASP C 3 80  ? 151.082 239.256 342.373 1.00 77.66  ? 80  ASP C OD2 1 
ATOM   4994 N N   . PRO C 3 81  ? 154.759 240.148 338.012 1.00 60.57  ? 81  PRO C N   1 
ATOM   4995 C CA  . PRO C 3 81  ? 156.020 239.776 337.360 1.00 63.09  ? 81  PRO C CA  1 
ATOM   4996 C C   . PRO C 3 81  ? 156.950 239.045 338.312 1.00 62.85  ? 81  PRO C C   1 
ATOM   4997 O O   . PRO C 3 81  ? 157.083 239.406 339.483 1.00 63.00  ? 81  PRO C O   1 
ATOM   4998 C CB  . PRO C 3 81  ? 156.605 241.124 336.924 1.00 58.54  ? 81  PRO C CB  1 
ATOM   4999 C CG  . PRO C 3 81  ? 155.983 242.120 337.828 1.00 60.83  ? 81  PRO C CG  1 
ATOM   5000 C CD  . PRO C 3 81  ? 154.607 241.609 338.115 1.00 63.14  ? 81  PRO C CD  1 
ATOM   5001 N N   . ILE C 3 82  ? 157.602 238.002 337.796 1.00 62.68  ? 82  ILE C N   1 
ATOM   5002 C CA  . ILE C 3 82  ? 158.651 237.349 338.567 1.00 61.44  ? 82  ILE C CA  1 
ATOM   5003 C C   . ILE C 3 82  ? 159.807 238.307 338.782 1.00 61.81  ? 82  ILE C C   1 
ATOM   5004 O O   . ILE C 3 82  ? 160.362 238.395 339.883 1.00 59.74  ? 82  ILE C O   1 
ATOM   5005 C CB  . ILE C 3 82  ? 159.119 236.059 337.875 1.00 62.57  ? 82  ILE C CB  1 
ATOM   5006 C CG1 . ILE C 3 82  ? 158.034 234.991 337.960 1.00 63.45  ? 82  ILE C CG1 1 
ATOM   5007 C CG2 . ILE C 3 82  ? 160.408 235.563 338.511 1.00 60.24  ? 82  ILE C CG2 1 
ATOM   5008 C CD1 . ILE C 3 82  ? 158.343 233.757 337.156 1.00 67.22  ? 82  ILE C CD1 1 
ATOM   5009 N N   . LEU C 3 83  ? 160.194 239.040 337.740 1.00 62.04  ? 83  LEU C N   1 
ATOM   5010 C CA  . LEU C 3 83  ? 161.271 240.010 337.890 1.00 59.93  ? 83  LEU C CA  1 
ATOM   5011 C C   . LEU C 3 83  ? 161.099 241.122 336.869 1.00 61.20  ? 83  LEU C C   1 
ATOM   5012 O O   . LEU C 3 83  ? 160.409 240.964 335.861 1.00 70.12  ? 83  LEU C O   1 
ATOM   5013 C CB  . LEU C 3 83  ? 162.648 239.358 337.738 1.00 61.22  ? 83  LEU C CB  1 
ATOM   5014 C CG  . LEU C 3 83  ? 163.109 239.019 336.319 1.00 61.41  ? 83  LEU C CG  1 
ATOM   5015 C CD1 . LEU C 3 83  ? 163.953 240.136 335.732 1.00 59.81  ? 83  LEU C CD1 1 
ATOM   5016 C CD2 . LEU C 3 83  ? 163.880 237.713 336.314 1.00 59.68  ? 83  LEU C CD2 1 
ATOM   5017 N N   . CYS C 3 84  ? 161.754 242.248 337.141 1.00 59.16  ? 84  CYS C N   1 
ATOM   5018 C CA  . CYS C 3 84  ? 161.676 243.421 336.285 1.00 63.33  ? 84  CYS C CA  1 
ATOM   5019 C C   . CYS C 3 84  ? 163.006 244.157 336.322 1.00 61.28  ? 84  CYS C C   1 
ATOM   5020 O O   . CYS C 3 84  ? 163.680 244.194 337.354 1.00 65.77  ? 84  CYS C O   1 
ATOM   5021 C CB  . CYS C 3 84  ? 160.550 244.360 336.726 1.00 65.36  ? 84  CYS C CB  1 
ATOM   5022 S SG  . CYS C 3 84  ? 158.898 243.634 336.665 1.00 74.90  ? 84  CYS C SG  1 
ATOM   5023 N N   . LEU C 3 85  ? 163.374 244.746 335.187 1.00 54.15  ? 85  LEU C N   1 
ATOM   5024 C CA  . LEU C 3 85  ? 164.585 245.550 335.108 1.00 56.62  ? 85  LEU C CA  1 
ATOM   5025 C C   . LEU C 3 85  ? 164.532 246.410 333.854 1.00 60.56  ? 85  LEU C C   1 
ATOM   5026 O O   . LEU C 3 85  ? 164.165 245.930 332.781 1.00 58.83  ? 85  LEU C O   1 
ATOM   5027 C CB  . LEU C 3 85  ? 165.840 244.670 335.095 1.00 55.24  ? 85  LEU C CB  1 
ATOM   5028 C CG  . LEU C 3 85  ? 166.136 243.892 333.809 1.00 55.04  ? 85  LEU C CG  1 
ATOM   5029 C CD1 . LEU C 3 85  ? 166.992 244.699 332.843 1.00 58.10  ? 85  LEU C CD1 1 
ATOM   5030 C CD2 . LEU C 3 85  ? 166.811 242.577 334.137 1.00 58.36  ? 85  LEU C CD2 1 
ATOM   5031 N N   . SER C 3 86  ? 164.902 247.678 333.998 1.00 58.88  ? 86  SER C N   1 
ATOM   5032 C CA  . SER C 3 86  ? 165.003 248.559 332.845 1.00 55.55  ? 86  SER C CA  1 
ATOM   5033 C C   . SER C 3 86  ? 166.254 248.230 332.037 1.00 51.56  ? 86  SER C C   1 
ATOM   5034 O O   . SER C 3 86  ? 167.287 247.834 332.582 1.00 53.33  ? 86  SER C O   1 
ATOM   5035 C CB  . SER C 3 86  ? 165.032 250.019 333.290 1.00 55.67  ? 86  SER C CB  1 
ATOM   5036 O OG  . SER C 3 86  ? 166.057 250.239 334.242 1.00 59.60  ? 86  SER C OG  1 
ATOM   5037 N N   . LEU C 3 87  ? 166.152 248.395 330.721 1.00 47.33  ? 87  LEU C N   1 
ATOM   5038 C CA  . LEU C 3 87  ? 167.262 248.088 329.821 1.00 51.46  ? 87  LEU C CA  1 
ATOM   5039 C C   . LEU C 3 87  ? 168.217 249.279 329.726 1.00 56.68  ? 87  LEU C C   1 
ATOM   5040 O O   . LEU C 3 87  ? 168.428 249.876 328.671 1.00 51.50  ? 87  LEU C O   1 
ATOM   5041 C CB  . LEU C 3 87  ? 166.735 247.689 328.449 1.00 56.98  ? 87  LEU C CB  1 
ATOM   5042 C CG  . LEU C 3 87  ? 167.784 247.177 327.461 1.00 56.94  ? 87  LEU C CG  1 
ATOM   5043 C CD1 . LEU C 3 87  ? 168.362 245.856 327.929 1.00 50.74  ? 87  LEU C CD1 1 
ATOM   5044 C CD2 . LEU C 3 87  ? 167.187 247.041 326.075 1.00 51.71  ? 87  LEU C CD2 1 
ATOM   5045 N N   . SER C 3 88  ? 168.795 249.620 330.872 1.00 61.24  ? 88  SER C N   1 
ATOM   5046 C CA  . SER C 3 88  ? 169.859 250.612 330.947 1.00 56.18  ? 88  SER C CA  1 
ATOM   5047 C C   . SER C 3 88  ? 171.143 249.880 331.312 1.00 57.66  ? 88  SER C C   1 
ATOM   5048 O O   . SER C 3 88  ? 171.560 249.900 332.476 1.00 62.97  ? 88  SER C O   1 
ATOM   5049 C CB  . SER C 3 88  ? 169.535 251.694 331.977 1.00 54.49  ? 88  SER C CB  1 
ATOM   5050 O OG  . SER C 3 88  ? 168.275 252.286 331.717 1.00 61.19  ? 88  SER C OG  1 
ATOM   5051 N N   . PRO C 3 89  ? 171.796 249.227 330.350 1.00 50.38  ? 89  PRO C N   1 
ATOM   5052 C CA  . PRO C 3 89  ? 172.888 248.310 330.709 1.00 54.11  ? 89  PRO C CA  1 
ATOM   5053 C C   . PRO C 3 89  ? 174.019 248.973 331.469 1.00 56.65  ? 89  PRO C C   1 
ATOM   5054 O O   . PRO C 3 89  ? 174.711 248.297 332.239 1.00 56.64  ? 89  PRO C O   1 
ATOM   5055 C CB  . PRO C 3 89  ? 173.356 247.779 329.347 1.00 55.38  ? 89  PRO C CB  1 
ATOM   5056 C CG  . PRO C 3 89  ? 172.938 248.814 328.370 1.00 43.61  ? 89  PRO C CG  1 
ATOM   5057 C CD  . PRO C 3 89  ? 171.651 249.365 328.893 1.00 48.33  ? 89  PRO C CD  1 
ATOM   5058 N N   . ALA C 3 90  ? 174.232 250.274 331.281 1.00 55.04  ? 90  ALA C N   1 
ATOM   5059 C CA  . ALA C 3 90  ? 175.356 250.956 331.903 1.00 49.30  ? 90  ALA C CA  1 
ATOM   5060 C C   . ALA C 3 90  ? 174.989 251.702 333.177 1.00 53.39  ? 90  ALA C C   1 
ATOM   5061 O O   . ALA C 3 90  ? 175.884 252.000 333.975 1.00 59.36  ? 90  ALA C O   1 
ATOM   5062 C CB  . ALA C 3 90  ? 175.983 251.945 330.917 1.00 42.64  ? 90  ALA C CB  1 
ATOM   5063 N N   . SER C 3 91  ? 173.710 252.014 333.390 1.00 55.67  ? 91  SER C N   1 
ATOM   5064 C CA  . SER C 3 91  ? 173.286 252.746 334.573 1.00 57.82  ? 91  SER C CA  1 
ATOM   5065 C C   . SER C 3 91  ? 172.302 251.991 335.450 1.00 59.60  ? 91  SER C C   1 
ATOM   5066 O O   . SER C 3 91  ? 172.129 252.371 336.612 1.00 59.32  ? 91  SER C O   1 
ATOM   5067 C CB  . SER C 3 91  ? 172.649 254.086 334.179 1.00 63.30  ? 91  SER C CB  1 
ATOM   5068 O OG  . SER C 3 91  ? 172.353 254.854 335.331 1.00 62.90  ? 91  SER C OG  1 
ATOM   5069 N N   . ASP C 3 92  ? 171.656 250.952 334.940 1.00 66.18  ? 92  ASP C N   1 
ATOM   5070 C CA  . ASP C 3 92  ? 170.779 250.149 335.774 1.00 67.20  ? 92  ASP C CA  1 
ATOM   5071 C C   . ASP C 3 92  ? 171.595 249.543 336.912 1.00 70.28  ? 92  ASP C C   1 
ATOM   5072 O O   . ASP C 3 92  ? 172.645 248.938 336.656 1.00 74.98  ? 92  ASP C O   1 
ATOM   5073 C CB  . ASP C 3 92  ? 170.118 249.049 334.944 1.00 64.85  ? 92  ASP C CB  1 
ATOM   5074 C CG  . ASP C 3 92  ? 169.119 248.230 335.738 1.00 67.25  ? 92  ASP C CG  1 
ATOM   5075 O OD1 . ASP C 3 92  ? 169.423 247.854 336.889 1.00 65.50  ? 92  ASP C OD1 1 
ATOM   5076 O OD2 . ASP C 3 92  ? 168.024 247.956 335.205 1.00 70.29  ? 92  ASP C OD2 1 
ATOM   5077 N N   . PRO C 3 93  ? 171.161 249.677 338.167 1.00 63.00  ? 93  PRO C N   1 
ATOM   5078 C CA  . PRO C 3 93  ? 171.989 249.168 339.271 1.00 58.75  ? 93  PRO C CA  1 
ATOM   5079 C C   . PRO C 3 93  ? 172.282 247.686 339.165 1.00 64.01  ? 93  PRO C C   1 
ATOM   5080 O O   . PRO C 3 93  ? 173.349 247.240 339.604 1.00 63.52  ? 93  PRO C O   1 
ATOM   5081 C CB  . PRO C 3 93  ? 171.153 249.494 340.515 1.00 55.38  ? 93  PRO C CB  1 
ATOM   5082 C CG  . PRO C 3 93  ? 169.760 249.611 340.017 1.00 58.92  ? 93  PRO C CG  1 
ATOM   5083 C CD  . PRO C 3 93  ? 169.872 250.200 338.649 1.00 60.21  ? 93  PRO C CD  1 
ATOM   5084 N N   . ARG C 3 94  ? 171.362 246.904 338.602 1.00 63.12  ? 94  ARG C N   1 
ATOM   5085 C CA  . ARG C 3 94  ? 171.596 245.474 338.445 1.00 58.15  ? 94  ARG C CA  1 
ATOM   5086 C C   . ARG C 3 94  ? 172.572 245.181 337.313 1.00 58.21  ? 94  ARG C C   1 
ATOM   5087 O O   . ARG C 3 94  ? 173.465 244.341 337.465 1.00 60.17  ? 94  ARG C O   1 
ATOM   5088 C CB  . ARG C 3 94  ? 170.267 244.758 338.215 1.00 52.00  ? 94  ARG C CB  1 
ATOM   5089 C CG  . ARG C 3 94  ? 169.433 244.649 339.477 1.00 57.05  ? 94  ARG C CG  1 
ATOM   5090 C CD  . ARG C 3 94  ? 167.962 244.454 339.182 1.00 62.19  ? 94  ARG C CD  1 
ATOM   5091 N NE  . ARG C 3 94  ? 167.351 245.667 338.656 1.00 64.31  ? 94  ARG C NE  1 
ATOM   5092 C CZ  . ARG C 3 94  ? 166.045 245.882 338.596 1.00 64.00  ? 94  ARG C CZ  1 
ATOM   5093 N NH1 . ARG C 3 94  ? 165.175 244.987 339.035 1.00 64.73  ? 94  ARG C NH1 1 
ATOM   5094 N NH2 . ARG C 3 94  ? 165.599 247.027 338.087 1.00 62.13  ? 94  ARG C NH2 1 
ATOM   5095 N N   . LEU C 3 95  ? 172.428 245.862 336.180 1.00 54.85  ? 95  LEU C N   1 
ATOM   5096 C CA  . LEU C 3 95  ? 173.293 245.632 335.032 1.00 56.90  ? 95  LEU C CA  1 
ATOM   5097 C C   . LEU C 3 95  ? 174.563 246.470 335.058 1.00 57.14  ? 95  LEU C C   1 
ATOM   5098 O O   . LEU C 3 95  ? 175.444 246.251 334.221 1.00 62.84  ? 95  LEU C O   1 
ATOM   5099 C CB  . LEU C 3 95  ? 172.533 245.920 333.733 1.00 57.06  ? 95  LEU C CB  1 
ATOM   5100 C CG  . LEU C 3 95  ? 171.434 244.929 333.349 1.00 55.51  ? 95  LEU C CG  1 
ATOM   5101 C CD1 . LEU C 3 95  ? 170.589 245.485 332.222 1.00 56.09  ? 95  LEU C CD1 1 
ATOM   5102 C CD2 . LEU C 3 95  ? 172.034 243.599 332.946 1.00 52.77  ? 95  LEU C CD2 1 
ATOM   5103 N N   . SER C 3 96  ? 174.685 247.414 335.992 1.00 57.69  ? 96  SER C N   1 
ATOM   5104 C CA  . SER C 3 96  ? 175.837 248.309 335.981 1.00 57.05  ? 96  SER C CA  1 
ATOM   5105 C C   . SER C 3 96  ? 177.137 247.549 336.207 1.00 54.14  ? 96  SER C C   1 
ATOM   5106 O O   . SER C 3 96  ? 178.156 247.852 335.578 1.00 49.77  ? 96  SER C O   1 
ATOM   5107 C CB  . SER C 3 96  ? 175.664 249.400 337.038 1.00 57.14  ? 96  SER C CB  1 
ATOM   5108 O OG  . SER C 3 96  ? 175.433 248.842 338.317 1.00 62.56  ? 96  SER C OG  1 
ATOM   5109 N N   . HIS C 3 97  ? 177.124 246.559 337.098 1.00 55.97  ? 97  HIS C N   1 
ATOM   5110 C CA  . HIS C 3 97  ? 178.337 245.864 337.503 1.00 53.39  ? 97  HIS C CA  1 
ATOM   5111 C C   . HIS C 3 97  ? 178.572 244.557 336.759 1.00 51.60  ? 97  HIS C C   1 
ATOM   5112 O O   . HIS C 3 97  ? 179.545 243.862 337.060 1.00 58.23  ? 97  HIS C O   1 
ATOM   5113 C CB  . HIS C 3 97  ? 178.307 245.596 339.009 1.00 59.34  ? 97  HIS C CB  1 
ATOM   5114 C CG  . HIS C 3 97  ? 178.567 246.812 339.839 1.00 60.83  ? 97  HIS C CG  1 
ATOM   5115 N ND1 . HIS C 3 97  ? 177.570 247.686 340.213 1.00 59.52  ? 97  HIS C ND1 1 
ATOM   5116 C CD2 . HIS C 3 97  ? 179.715 247.308 340.358 1.00 57.17  ? 97  HIS C CD2 1 
ATOM   5117 C CE1 . HIS C 3 97  ? 178.091 248.664 340.932 1.00 55.94  ? 97  HIS C CE1 1 
ATOM   5118 N NE2 . HIS C 3 97  ? 179.391 248.458 341.034 1.00 56.59  ? 97  HIS C NE2 1 
ATOM   5119 N N   . THR C 3 98  ? 177.719 244.199 335.805 1.00 51.71  ? 98  THR C N   1 
ATOM   5120 C CA  . THR C 3 98  ? 178.017 243.050 334.967 1.00 48.09  ? 98  THR C CA  1 
ATOM   5121 C C   . THR C 3 98  ? 179.147 243.393 334.002 1.00 51.65  ? 98  THR C C   1 
ATOM   5122 O O   . THR C 3 98  ? 179.444 244.562 333.743 1.00 56.35  ? 98  THR C O   1 
ATOM   5123 C CB  . THR C 3 98  ? 176.781 242.607 334.186 1.00 48.50  ? 98  THR C CB  1 
ATOM   5124 O OG1 . THR C 3 98  ? 176.299 243.695 333.389 1.00 53.53  ? 98  THR C OG1 1 
ATOM   5125 C CG2 . THR C 3 98  ? 175.688 242.154 335.132 1.00 55.78  ? 98  THR C CG2 1 
ATOM   5126 N N   . MET C 3 99  ? 179.787 242.352 333.466 1.00 50.31  ? 99  MET C N   1 
ATOM   5127 C CA  . MET C 3 99  ? 180.911 242.577 332.564 1.00 51.94  ? 99  MET C CA  1 
ATOM   5128 C C   . MET C 3 99  ? 180.507 243.481 331.409 1.00 59.46  ? 99  MET C C   1 
ATOM   5129 O O   . MET C 3 99  ? 181.253 244.392 331.033 1.00 63.93  ? 99  MET C O   1 
ATOM   5130 C CB  . MET C 3 99  ? 181.442 241.243 332.044 1.00 54.85  ? 99  MET C CB  1 
ATOM   5131 C CG  . MET C 3 99  ? 182.766 241.342 331.305 1.00 54.04  ? 99  MET C CG  1 
ATOM   5132 S SD  . MET C 3 99  ? 184.116 241.882 332.369 1.00 57.55  ? 99  MET C SD  1 
ATOM   5133 C CE  . MET C 3 99  ? 185.521 241.652 331.285 1.00 55.36  ? 99  MET C CE  1 
ATOM   5134 N N   . LEU C 3 100 ? 179.323 243.255 330.840 1.00 50.78  ? 100 LEU C N   1 
ATOM   5135 C CA  . LEU C 3 100 ? 178.811 244.173 329.829 1.00 39.57  ? 100 LEU C CA  1 
ATOM   5136 C C   . LEU C 3 100 ? 178.721 245.587 330.386 1.00 47.65  ? 100 LEU C C   1 
ATOM   5137 O O   . LEU C 3 100 ? 179.160 246.548 329.746 1.00 58.32  ? 100 LEU C O   1 
ATOM   5138 C CB  . LEU C 3 100 ? 177.443 243.698 329.340 1.00 53.42  ? 100 LEU C CB  1 
ATOM   5139 C CG  . LEU C 3 100 ? 176.738 244.595 328.321 1.00 57.97  ? 100 LEU C CG  1 
ATOM   5140 C CD1 . LEU C 3 100 ? 177.518 244.650 327.022 1.00 57.67  ? 100 LEU C CD1 1 
ATOM   5141 C CD2 . LEU C 3 100 ? 175.322 244.109 328.077 1.00 52.33  ? 100 LEU C CD2 1 
ATOM   5142 N N   . GLY C 3 101 ? 178.165 245.730 331.589 1.00 49.12  ? 101 GLY C N   1 
ATOM   5143 C CA  . GLY C 3 101 ? 178.064 247.048 332.193 1.00 51.11  ? 101 GLY C CA  1 
ATOM   5144 C C   . GLY C 3 101 ? 179.417 247.650 332.516 1.00 62.11  ? 101 GLY C C   1 
ATOM   5145 O O   . GLY C 3 101 ? 179.629 248.853 332.341 1.00 64.44  ? 101 GLY C O   1 
ATOM   5146 N N   . GLU C 3 102 ? 180.350 246.828 333.002 1.00 54.28  ? 102 GLU C N   1 
ATOM   5147 C CA  . GLU C 3 102 ? 181.679 247.337 333.320 1.00 42.39  ? 102 GLU C CA  1 
ATOM   5148 C C   . GLU C 3 102 ? 182.381 247.848 332.071 1.00 42.81  ? 102 GLU C C   1 
ATOM   5149 O O   . GLU C 3 102 ? 183.028 248.901 332.101 1.00 51.63  ? 102 GLU C O   1 
ATOM   5150 C CB  . GLU C 3 102 ? 182.515 246.250 333.992 1.00 50.29  ? 102 GLU C CB  1 
ATOM   5151 C CG  . GLU C 3 102 ? 181.999 245.802 335.350 1.00 57.30  ? 102 GLU C CG  1 
ATOM   5152 C CD  . GLU C 3 102 ? 182.277 246.808 336.448 1.00 59.57  ? 102 GLU C CD  1 
ATOM   5153 O OE1 . GLU C 3 102 ? 182.318 248.020 336.154 1.00 57.38  ? 102 GLU C OE1 1 
ATOM   5154 O OE2 . GLU C 3 102 ? 182.462 246.386 337.608 1.00 58.70  ? 102 GLU C OE2 1 
ATOM   5155 N N   . ILE C 3 103 ? 182.272 247.116 330.963 1.00 39.89  ? 103 ILE C N   1 
ATOM   5156 C CA  . ILE C 3 103 ? 182.876 247.577 329.719 1.00 44.06  ? 103 ILE C CA  1 
ATOM   5157 C C   . ILE C 3 103 ? 182.168 248.827 329.217 1.00 47.11  ? 103 ILE C C   1 
ATOM   5158 O O   . ILE C 3 103 ? 182.805 249.751 328.701 1.00 50.56  ? 103 ILE C O   1 
ATOM   5159 C CB  . ILE C 3 103 ? 182.863 246.455 328.665 1.00 44.48  ? 103 ILE C CB  1 
ATOM   5160 C CG1 . ILE C 3 103 ? 184.112 245.584 328.797 1.00 46.93  ? 103 ILE C CG1 1 
ATOM   5161 C CG2 . ILE C 3 103 ? 182.797 247.030 327.258 1.00 46.00  ? 103 ILE C CG2 1 
ATOM   5162 C CD1 . ILE C 3 103 ? 184.204 244.827 330.094 1.00 51.34  ? 103 ILE C CD1 1 
ATOM   5163 N N   . LEU C 3 104 ? 180.842 248.878 329.352 1.00 41.21  ? 104 LEU C N   1 
ATOM   5164 C CA  . LEU C 3 104 ? 180.102 250.036 328.870 1.00 36.69  ? 104 LEU C CA  1 
ATOM   5165 C C   . LEU C 3 104 ? 180.490 251.295 329.628 1.00 43.82  ? 104 LEU C C   1 
ATOM   5166 O O   . LEU C 3 104 ? 180.636 252.367 329.031 1.00 54.02  ? 104 LEU C O   1 
ATOM   5167 C CB  . LEU C 3 104 ? 178.601 249.784 328.991 1.00 40.03  ? 104 LEU C CB  1 
ATOM   5168 C CG  . LEU C 3 104 ? 177.980 248.965 327.863 1.00 47.82  ? 104 LEU C CG  1 
ATOM   5169 C CD1 . LEU C 3 104 ? 176.576 248.539 328.227 1.00 49.41  ? 104 LEU C CD1 1 
ATOM   5170 C CD2 . LEU C 3 104 ? 177.969 249.775 326.587 1.00 46.48  ? 104 LEU C CD2 1 
ATOM   5171 N N   . ASN C 3 105 ? 180.670 251.189 330.944 1.00 41.29  ? 105 ASN C N   1 
ATOM   5172 C CA  . ASN C 3 105 ? 180.958 252.372 331.745 1.00 48.11  ? 105 ASN C CA  1 
ATOM   5173 C C   . ASN C 3 105 ? 182.266 253.050 331.359 1.00 47.55  ? 105 ASN C C   1 
ATOM   5174 O O   . ASN C 3 105 ? 182.554 254.134 331.877 1.00 48.67  ? 105 ASN C O   1 
ATOM   5175 C CB  . ASN C 3 105 ? 180.976 252.000 333.223 1.00 49.96  ? 105 ASN C CB  1 
ATOM   5176 C CG  . ASN C 3 105 ? 179.594 252.000 333.832 1.00 56.02  ? 105 ASN C CG  1 
ATOM   5177 O OD1 . ASN C 3 105 ? 179.347 252.660 334.840 1.00 58.42  ? 105 ASN C OD1 1 
ATOM   5178 N ND2 . ASN C 3 105 ? 178.676 251.269 333.212 1.00 52.57  ? 105 ASN C ND2 1 
ATOM   5179 N N   . TYR C 3 106 ? 183.061 252.450 330.479 1.00 41.62  ? 106 TYR C N   1 
ATOM   5180 C CA  . TYR C 3 106 ? 184.228 253.110 329.914 1.00 35.13  ? 106 TYR C CA  1 
ATOM   5181 C C   . TYR C 3 106 ? 183.933 253.787 328.582 1.00 40.64  ? 106 TYR C C   1 
ATOM   5182 O O   . TYR C 3 106 ? 184.835 254.398 328.001 1.00 52.69  ? 106 TYR C O   1 
ATOM   5183 C CB  . TYR C 3 106 ? 185.369 252.106 329.736 1.00 36.42  ? 106 TYR C CB  1 
ATOM   5184 C CG  . TYR C 3 106 ? 186.115 251.812 331.012 1.00 39.65  ? 106 TYR C CG  1 
ATOM   5185 C CD1 . TYR C 3 106 ? 187.111 252.660 331.465 1.00 38.36  ? 106 TYR C CD1 1 
ATOM   5186 C CD2 . TYR C 3 106 ? 185.824 250.686 331.765 1.00 47.87  ? 106 TYR C CD2 1 
ATOM   5187 C CE1 . TYR C 3 106 ? 187.795 252.397 332.632 1.00 36.17  ? 106 TYR C CE1 1 
ATOM   5188 C CE2 . TYR C 3 106 ? 186.503 250.416 332.933 1.00 42.23  ? 106 TYR C CE2 1 
ATOM   5189 C CZ  . TYR C 3 106 ? 187.486 251.274 333.360 1.00 40.63  ? 106 TYR C CZ  1 
ATOM   5190 O OH  . TYR C 3 106 ? 188.165 251.009 334.523 1.00 54.43  ? 106 TYR C OH  1 
ATOM   5191 N N   . TYR C 3 107 ? 182.703 253.696 328.088 1.00 30.84  ? 107 TYR C N   1 
ATOM   5192 C CA  . TYR C 3 107 ? 182.296 254.353 326.857 1.00 33.62  ? 107 TYR C CA  1 
ATOM   5193 C C   . TYR C 3 107 ? 180.957 255.036 327.085 1.00 41.04  ? 107 TYR C C   1 
ATOM   5194 O O   . TYR C 3 107 ? 180.137 254.570 327.878 1.00 44.92  ? 107 TYR C O   1 
ATOM   5195 C CB  . TYR C 3 107 ? 182.191 253.357 325.704 1.00 35.32  ? 107 TYR C CB  1 
ATOM   5196 C CG  . TYR C 3 107 ? 183.494 252.670 325.369 1.00 31.50  ? 107 TYR C CG  1 
ATOM   5197 C CD1 . TYR C 3 107 ? 183.972 251.634 326.148 1.00 37.70  ? 107 TYR C CD1 1 
ATOM   5198 C CD2 . TYR C 3 107 ? 184.239 253.056 324.268 1.00 35.08  ? 107 TYR C CD2 1 
ATOM   5199 C CE1 . TYR C 3 107 ? 185.157 251.004 325.844 1.00 38.78  ? 107 TYR C CE1 1 
ATOM   5200 C CE2 . TYR C 3 107 ? 185.425 252.432 323.956 1.00 32.31  ? 107 TYR C CE2 1 
ATOM   5201 C CZ  . TYR C 3 107 ? 185.878 251.408 324.747 1.00 31.10  ? 107 TYR C CZ  1 
ATOM   5202 O OH  . TYR C 3 107 ? 187.060 250.781 324.440 1.00 39.56  ? 107 TYR C OH  1 
ATOM   5203 N N   . THR C 3 108 ? 180.741 256.151 326.391 1.00 38.94  ? 108 THR C N   1 
ATOM   5204 C CA  . THR C 3 108 ? 179.543 256.956 326.588 1.00 41.54  ? 108 THR C CA  1 
ATOM   5205 C C   . THR C 3 108 ? 178.468 256.700 325.540 1.00 41.74  ? 108 THR C C   1 
ATOM   5206 O O   . THR C 3 108 ? 177.384 257.280 325.635 1.00 38.11  ? 108 THR C O   1 
ATOM   5207 C CB  . THR C 3 108 ? 179.904 258.444 326.603 1.00 34.51  ? 108 THR C CB  1 
ATOM   5208 O OG1 . THR C 3 108 ? 179.040 259.133 327.514 1.00 45.37  ? 108 THR C OG1 1 
ATOM   5209 C CG2 . THR C 3 108 ? 179.755 259.058 325.231 1.00 36.62  ? 108 THR C CG2 1 
ATOM   5210 N N   . HIS C 3 109 ? 178.736 255.849 324.554 1.00 42.13  ? 109 HIS C N   1 
ATOM   5211 C CA  . HIS C 3 109 ? 177.770 255.503 323.522 1.00 35.48  ? 109 HIS C CA  1 
ATOM   5212 C C   . HIS C 3 109 ? 177.767 253.996 323.335 1.00 35.81  ? 109 HIS C C   1 
ATOM   5213 O O   . HIS C 3 109 ? 178.822 253.359 323.380 1.00 44.61  ? 109 HIS C O   1 
ATOM   5214 C CB  . HIS C 3 109 ? 178.100 256.183 322.190 1.00 37.16  ? 109 HIS C CB  1 
ATOM   5215 C CG  . HIS C 3 109 ? 177.955 257.671 322.213 1.00 38.93  ? 109 HIS C CG  1 
ATOM   5216 N ND1 . HIS C 3 109 ? 178.612 258.495 321.326 1.00 32.65  ? 109 HIS C ND1 1 
ATOM   5217 C CD2 . HIS C 3 109 ? 177.217 258.484 323.004 1.00 41.27  ? 109 HIS C CD2 1 
ATOM   5218 C CE1 . HIS C 3 109 ? 178.292 259.752 321.575 1.00 32.48  ? 109 HIS C CE1 1 
ATOM   5219 N NE2 . HIS C 3 109 ? 177.447 259.773 322.589 1.00 33.05  ? 109 HIS C NE2 1 
ATOM   5220 N N   . TRP C 3 110 ? 176.583 253.429 323.125 1.00 31.02  ? 110 TRP C N   1 
ATOM   5221 C CA  . TRP C 3 110 ? 176.465 252.004 322.858 1.00 34.78  ? 110 TRP C CA  1 
ATOM   5222 C C   . TRP C 3 110 ? 175.262 251.771 321.961 1.00 31.04  ? 110 TRP C C   1 
ATOM   5223 O O   . TRP C 3 110 ? 174.255 252.475 322.057 1.00 49.64  ? 110 TRP C O   1 
ATOM   5224 C CB  . TRP C 3 110 ? 176.337 251.196 324.152 1.00 38.72  ? 110 TRP C CB  1 
ATOM   5225 C CG  . TRP C 3 110 ? 175.005 251.302 324.823 1.00 36.34  ? 110 TRP C CG  1 
ATOM   5226 C CD1 . TRP C 3 110 ? 174.633 252.210 325.766 1.00 36.29  ? 110 TRP C CD1 1 
ATOM   5227 C CD2 . TRP C 3 110 ? 173.871 250.454 324.615 1.00 39.86  ? 110 TRP C CD2 1 
ATOM   5228 N NE1 . TRP C 3 110 ? 173.336 251.986 326.156 1.00 36.07  ? 110 TRP C NE1 1 
ATOM   5229 C CE2 . TRP C 3 110 ? 172.847 250.912 325.462 1.00 40.19  ? 110 TRP C CE2 1 
ATOM   5230 C CE3 . TRP C 3 110 ? 173.623 249.354 323.792 1.00 35.13  ? 110 TRP C CE3 1 
ATOM   5231 C CZ2 . TRP C 3 110 ? 171.595 250.310 325.508 1.00 44.89  ? 110 TRP C CZ2 1 
ATOM   5232 C CZ3 . TRP C 3 110 ? 172.381 248.759 323.840 1.00 36.86  ? 110 TRP C CZ3 1 
ATOM   5233 C CH2 . TRP C 3 110 ? 171.382 249.236 324.691 1.00 38.79  ? 110 TRP C CH2 1 
ATOM   5234 N N   . ALA C 3 111 ? 175.375 250.775 321.088 1.00 24.47  ? 111 ALA C N   1 
ATOM   5235 C CA  . ALA C 3 111 ? 174.319 250.491 320.122 1.00 30.75  ? 111 ALA C CA  1 
ATOM   5236 C C   . ALA C 3 111 ? 174.462 249.057 319.646 1.00 43.36  ? 111 ALA C C   1 
ATOM   5237 O O   . ALA C 3 111 ? 175.479 248.709 319.041 1.00 54.62  ? 111 ALA C O   1 
ATOM   5238 C CB  . ALA C 3 111 ? 174.391 251.455 318.943 1.00 32.89  ? 111 ALA C CB  1 
ATOM   5239 N N   . GLY C 3 112 ? 173.454 248.235 319.907 1.00 40.24  ? 112 GLY C N   1 
ATOM   5240 C CA  . GLY C 3 112 ? 173.484 246.862 319.454 1.00 33.76  ? 112 GLY C CA  1 
ATOM   5241 C C   . GLY C 3 112 ? 172.315 246.083 320.018 1.00 38.42  ? 112 GLY C C   1 
ATOM   5242 O O   . GLY C 3 112 ? 171.400 246.645 320.624 1.00 46.29  ? 112 GLY C O   1 
ATOM   5243 N N   . SER C 3 113 ? 172.370 244.773 319.803 1.00 45.38  ? 113 SER C N   1 
ATOM   5244 C CA  . SER C 3 113 ? 171.342 243.850 320.262 1.00 48.03  ? 113 SER C CA  1 
ATOM   5245 C C   . SER C 3 113 ? 171.857 243.087 321.471 1.00 45.76  ? 113 SER C C   1 
ATOM   5246 O O   . SER C 3 113 ? 172.946 242.506 321.423 1.00 48.02  ? 113 SER C O   1 
ATOM   5247 C CB  . SER C 3 113 ? 170.965 242.873 319.150 1.00 46.83  ? 113 SER C CB  1 
ATOM   5248 O OG  . SER C 3 113 ? 170.864 243.538 317.905 1.00 46.15  ? 113 SER C OG  1 
ATOM   5249 N N   . LEU C 3 114 ? 171.081 243.086 322.549 1.00 47.77  ? 114 LEU C N   1 
ATOM   5250 C CA  . LEU C 3 114 ? 171.495 242.385 323.753 1.00 46.60  ? 114 LEU C CA  1 
ATOM   5251 C C   . LEU C 3 114 ? 170.977 240.952 323.734 1.00 50.73  ? 114 LEU C C   1 
ATOM   5252 O O   . LEU C 3 114 ? 170.097 240.590 322.955 1.00 54.35  ? 114 LEU C O   1 
ATOM   5253 C CB  . LEU C 3 114 ? 171.007 243.112 325.007 1.00 41.10  ? 114 LEU C CB  1 
ATOM   5254 C CG  . LEU C 3 114 ? 171.609 244.483 325.324 1.00 46.25  ? 114 LEU C CG  1 
ATOM   5255 C CD1 . LEU C 3 114 ? 171.643 244.694 326.825 1.00 45.70  ? 114 LEU C CD1 1 
ATOM   5256 C CD2 . LEU C 3 114 ? 172.998 244.653 324.741 1.00 48.13  ? 114 LEU C CD2 1 
ATOM   5257 N N   . LYS C 3 115 ? 171.519 240.135 324.635 1.00 44.71  ? 115 LYS C N   1 
ATOM   5258 C CA  . LYS C 3 115 ? 171.221 238.705 324.696 1.00 36.01  ? 115 LYS C CA  1 
ATOM   5259 C C   . LYS C 3 115 ? 171.071 238.365 326.176 1.00 43.72  ? 115 LYS C C   1 
ATOM   5260 O O   . LYS C 3 115 ? 172.069 238.254 326.897 1.00 55.89  ? 115 LYS C O   1 
ATOM   5261 C CB  . LYS C 3 115 ? 172.319 237.891 324.029 1.00 43.52  ? 115 LYS C CB  1 
ATOM   5262 C CG  . LYS C 3 115 ? 171.970 236.441 323.791 1.00 46.49  ? 115 LYS C CG  1 
ATOM   5263 C CD  . LYS C 3 115 ? 173.220 235.597 323.606 1.00 50.02  ? 115 LYS C CD  1 
ATOM   5264 C CE  . LYS C 3 115 ? 174.059 236.039 322.411 1.00 50.14  ? 115 LYS C CE  1 
ATOM   5265 N NZ  . LYS C 3 115 ? 173.501 235.562 321.120 1.00 47.29  ? 115 LYS C NZ  1 
ATOM   5266 N N   . PHE C 3 116 ? 169.824 238.273 326.632 1.00 48.50  ? 116 PHE C N   1 
ATOM   5267 C CA  . PHE C 3 116 ? 169.523 237.867 327.999 1.00 49.81  ? 116 PHE C CA  1 
ATOM   5268 C C   . PHE C 3 116 ? 169.230 236.372 328.033 1.00 52.81  ? 116 PHE C C   1 
ATOM   5269 O O   . PHE C 3 116 ? 168.217 235.924 327.493 1.00 59.26  ? 116 PHE C O   1 
ATOM   5270 C CB  . PHE C 3 116 ? 168.327 238.644 328.541 1.00 45.40  ? 116 PHE C CB  1 
ATOM   5271 C CG  . PHE C 3 116 ? 168.653 240.036 328.972 1.00 43.32  ? 116 PHE C CG  1 
ATOM   5272 C CD1 . PHE C 3 116 ? 169.028 240.991 328.049 1.00 54.38  ? 116 PHE C CD1 1 
ATOM   5273 C CD2 . PHE C 3 116 ? 168.568 240.395 330.303 1.00 47.28  ? 116 PHE C CD2 1 
ATOM   5274 C CE1 . PHE C 3 116 ? 169.322 242.276 328.447 1.00 59.19  ? 116 PHE C CE1 1 
ATOM   5275 C CE2 . PHE C 3 116 ? 168.861 241.678 330.705 1.00 52.15  ? 116 PHE C CE2 1 
ATOM   5276 C CZ  . PHE C 3 116 ? 169.238 242.620 329.776 1.00 54.40  ? 116 PHE C CZ  1 
ATOM   5277 N N   . THR C 3 117 ? 170.092 235.610 328.691 1.00 52.34  ? 117 THR C N   1 
ATOM   5278 C CA  . THR C 3 117 ? 169.870 234.190 328.909 1.00 53.82  ? 117 THR C CA  1 
ATOM   5279 C C   . THR C 3 117 ? 169.421 233.969 330.347 1.00 57.02  ? 117 THR C C   1 
ATOM   5280 O O   . THR C 3 117 ? 169.795 234.716 331.252 1.00 58.75  ? 117 THR C O   1 
ATOM   5281 C CB  . THR C 3 117 ? 171.134 233.370 328.626 1.00 58.50  ? 117 THR C CB  1 
ATOM   5282 O OG1 . THR C 3 117 ? 171.541 233.560 327.265 1.00 61.19  ? 117 THR C OG1 1 
ATOM   5283 C CG2 . THR C 3 117 ? 170.882 231.886 328.874 1.00 52.03  ? 117 THR C CG2 1 
ATOM   5284 N N   . PHE C 3 118 ? 168.590 232.955 330.544 1.00 57.54  ? 118 PHE C N   1 
ATOM   5285 C CA  . PHE C 3 118 ? 168.127 232.566 331.867 1.00 52.28  ? 118 PHE C CA  1 
ATOM   5286 C C   . PHE C 3 118 ? 168.298 231.067 332.017 1.00 54.31  ? 118 PHE C C   1 
ATOM   5287 O O   . PHE C 3 118 ? 167.920 230.310 331.123 1.00 64.12  ? 118 PHE C O   1 
ATOM   5288 C CB  . PHE C 3 118 ? 166.657 232.934 332.090 1.00 43.02  ? 118 PHE C CB  1 
ATOM   5289 C CG  . PHE C 3 118 ? 166.394 234.409 332.099 1.00 49.95  ? 118 PHE C CG  1 
ATOM   5290 C CD1 . PHE C 3 118 ? 166.171 235.091 330.919 1.00 55.37  ? 118 PHE C CD1 1 
ATOM   5291 C CD2 . PHE C 3 118 ? 166.357 235.112 333.289 1.00 54.62  ? 118 PHE C CD2 1 
ATOM   5292 C CE1 . PHE C 3 118 ? 165.924 236.445 330.924 1.00 56.77  ? 118 PHE C CE1 1 
ATOM   5293 C CE2 . PHE C 3 118 ? 166.111 236.468 333.297 1.00 55.56  ? 118 PHE C CE2 1 
ATOM   5294 C CZ  . PHE C 3 118 ? 165.895 237.134 332.113 1.00 55.60  ? 118 PHE C CZ  1 
ATOM   5295 N N   . MET C 3 119 ? 168.861 230.643 333.146 1.00 54.23  ? 119 MET C N   1 
ATOM   5296 C CA  . MET C 3 119 ? 169.064 229.232 333.448 1.00 55.64  ? 119 MET C CA  1 
ATOM   5297 C C   . MET C 3 119 ? 168.216 228.856 334.651 1.00 60.05  ? 119 MET C C   1 
ATOM   5298 O O   . MET C 3 119 ? 168.181 229.590 335.642 1.00 60.87  ? 119 MET C O   1 
ATOM   5299 C CB  . MET C 3 119 ? 170.536 228.927 333.729 1.00 57.95  ? 119 MET C CB  1 
ATOM   5300 C CG  . MET C 3 119 ? 170.785 227.498 334.188 1.00 60.93  ? 119 MET C CG  1 
ATOM   5301 S SD  . MET C 3 119 ? 172.527 227.046 334.183 1.00 72.28  ? 119 MET C SD  1 
ATOM   5302 C CE  . MET C 3 119 ? 173.191 228.264 335.311 1.00 60.96  ? 119 MET C CE  1 
ATOM   5303 N N   . PHE C 3 120 ? 167.539 227.714 334.568 1.00 61.60  ? 120 PHE C N   1 
ATOM   5304 C CA  . PHE C 3 120 ? 166.636 227.254 335.622 1.00 60.87  ? 120 PHE C CA  1 
ATOM   5305 C C   . PHE C 3 120 ? 167.373 226.231 336.477 1.00 63.93  ? 120 PHE C C   1 
ATOM   5306 O O   . PHE C 3 120 ? 167.445 225.049 336.142 1.00 72.59  ? 120 PHE C O   1 
ATOM   5307 C CB  . PHE C 3 120 ? 165.365 226.666 335.025 1.00 60.41  ? 120 PHE C CB  1 
ATOM   5308 C CG  . PHE C 3 120 ? 164.448 226.056 336.040 1.00 61.45  ? 120 PHE C CG  1 
ATOM   5309 C CD1 . PHE C 3 120 ? 163.545 226.838 336.735 1.00 64.99  ? 120 PHE C CD1 1 
ATOM   5310 C CD2 . PHE C 3 120 ? 164.483 224.699 336.296 1.00 64.24  ? 120 PHE C CD2 1 
ATOM   5311 C CE1 . PHE C 3 120 ? 162.699 226.279 337.668 1.00 65.79  ? 120 PHE C CE1 1 
ATOM   5312 C CE2 . PHE C 3 120 ? 163.637 224.136 337.226 1.00 65.07  ? 120 PHE C CE2 1 
ATOM   5313 C CZ  . PHE C 3 120 ? 162.746 224.927 337.913 1.00 65.01  ? 120 PHE C CZ  1 
ATOM   5314 N N   . CYS C 3 121 ? 167.920 226.693 337.600 1.00 61.52  ? 121 CYS C N   1 
ATOM   5315 C CA  . CYS C 3 121 ? 168.623 225.816 338.536 1.00 63.19  ? 121 CYS C CA  1 
ATOM   5316 C C   . CYS C 3 121 ? 167.622 225.229 339.530 1.00 63.04  ? 121 CYS C C   1 
ATOM   5317 O O   . CYS C 3 121 ? 167.556 225.600 340.703 1.00 62.10  ? 121 CYS C O   1 
ATOM   5318 C CB  . CYS C 3 121 ? 169.737 226.577 339.241 1.00 60.95  ? 121 CYS C CB  1 
ATOM   5319 S SG  . CYS C 3 121 ? 171.068 227.111 338.144 1.00 68.29  ? 121 CYS C SG  1 
ATOM   5320 N N   . GLY C 3 122 ? 166.826 224.289 339.026 1.00 62.44  ? 122 GLY C N   1 
ATOM   5321 C CA  . GLY C 3 122 ? 165.837 223.609 339.837 1.00 60.64  ? 122 GLY C CA  1 
ATOM   5322 C C   . GLY C 3 122 ? 165.901 222.104 339.684 1.00 63.73  ? 122 GLY C C   1 
ATOM   5323 O O   . GLY C 3 122 ? 166.797 221.582 339.016 1.00 64.98  ? 122 GLY C O   1 
ATOM   5324 N N   . SER C 3 123 ? 164.958 221.395 340.296 1.00 67.96  ? 123 SER C N   1 
ATOM   5325 C CA  . SER C 3 123 ? 164.951 219.944 340.223 1.00 68.84  ? 123 SER C CA  1 
ATOM   5326 C C   . SER C 3 123 ? 164.563 219.480 338.823 1.00 67.94  ? 123 SER C C   1 
ATOM   5327 O O   . SER C 3 123 ? 163.996 220.229 338.023 1.00 69.15  ? 123 SER C O   1 
ATOM   5328 C CB  . SER C 3 123 ? 163.985 219.361 341.252 1.00 70.30  ? 123 SER C CB  1 
ATOM   5329 O OG  . SER C 3 123 ? 162.677 219.867 341.062 1.00 69.34  ? 123 SER C OG  1 
ATOM   5330 N N   . MET C 3 124 ? 164.880 218.217 338.530 1.00 63.46  ? 124 MET C N   1 
ATOM   5331 C CA  . MET C 3 124 ? 164.578 217.660 337.218 1.00 64.38  ? 124 MET C CA  1 
ATOM   5332 C C   . MET C 3 124 ? 163.089 217.425 337.020 1.00 64.00  ? 124 MET C C   1 
ATOM   5333 O O   . MET C 3 124 ? 162.628 217.393 335.875 1.00 62.27  ? 124 MET C O   1 
ATOM   5334 C CB  . MET C 3 124 ? 165.336 216.348 337.019 1.00 65.61  ? 124 MET C CB  1 
ATOM   5335 C CG  . MET C 3 124 ? 165.028 215.635 335.710 1.00 66.80  ? 124 MET C CG  1 
ATOM   5336 S SD  . MET C 3 124 ? 165.336 216.655 334.260 1.00 80.25  ? 124 MET C SD  1 
ATOM   5337 C CE  . MET C 3 124 ? 164.877 215.526 332.950 1.00 64.94  ? 124 MET C CE  1 
ATOM   5338 N N   . MET C 3 125 ? 162.329 217.259 338.098 1.00 69.14  ? 125 MET C N   1 
ATOM   5339 C CA  . MET C 3 125 ? 160.895 217.029 338.005 1.00 68.66  ? 125 MET C CA  1 
ATOM   5340 C C   . MET C 3 125 ? 160.085 218.317 338.048 1.00 66.50  ? 125 MET C C   1 
ATOM   5341 O O   . MET C 3 125 ? 158.853 218.258 337.988 1.00 69.36  ? 125 MET C O   1 
ATOM   5342 C CB  . MET C 3 125 ? 160.436 216.105 339.135 1.00 70.45  ? 125 MET C CB  1 
ATOM   5343 C CG  . MET C 3 125 ? 161.094 214.738 339.130 1.00 67.87  ? 125 MET C CG  1 
ATOM   5344 S SD  . MET C 3 125 ? 160.698 213.781 337.658 1.00 71.47  ? 125 MET C SD  1 
ATOM   5345 C CE  . MET C 3 125 ? 161.600 212.275 337.999 1.00 70.50  ? 125 MET C CE  1 
ATOM   5346 N N   . ALA C 3 126 ? 160.737 219.471 338.149 1.00 71.19  ? 126 ALA C N   1 
ATOM   5347 C CA  . ALA C 3 126 ? 160.049 220.755 338.168 1.00 69.04  ? 126 ALA C CA  1 
ATOM   5348 C C   . ALA C 3 126 ? 159.853 221.213 336.730 1.00 66.16  ? 126 ALA C C   1 
ATOM   5349 O O   . ALA C 3 126 ? 160.814 221.595 336.055 1.00 67.55  ? 126 ALA C O   1 
ATOM   5350 C CB  . ALA C 3 126 ? 160.844 221.784 338.966 1.00 70.27  ? 126 ALA C CB  1 
ATOM   5351 N N   . THR C 3 127 ? 158.612 221.170 336.260 1.00 72.92  ? 127 THR C N   1 
ATOM   5352 C CA  . THR C 3 127 ? 158.270 221.577 334.909 1.00 76.64  ? 127 THR C CA  1 
ATOM   5353 C C   . THR C 3 127 ? 157.335 222.775 334.963 1.00 77.92  ? 127 THR C C   1 
ATOM   5354 O O   . THR C 3 127 ? 156.560 222.938 335.909 1.00 79.53  ? 127 THR C O   1 
ATOM   5355 C CB  . THR C 3 127 ? 157.610 220.435 334.126 1.00 77.99  ? 127 THR C CB  1 
ATOM   5356 O OG1 . THR C 3 127 ? 157.388 220.844 332.771 1.00 76.19  ? 127 THR C OG1 1 
ATOM   5357 C CG2 . THR C 3 127 ? 156.283 220.040 334.758 1.00 75.27  ? 127 THR C CG2 1 
ATOM   5358 N N   . GLY C 3 128 ? 157.422 223.615 333.941 1.00 69.49  ? 128 GLY C N   1 
ATOM   5359 C CA  . GLY C 3 128 ? 156.604 224.809 333.900 1.00 64.06  ? 128 GLY C CA  1 
ATOM   5360 C C   . GLY C 3 128 ? 156.932 225.628 332.675 1.00 63.73  ? 128 GLY C C   1 
ATOM   5361 O O   . GLY C 3 128 ? 157.629 225.173 331.767 1.00 62.80  ? 128 GLY C O   1 
ATOM   5362 N N   . LYS C 3 129 ? 156.411 226.851 332.661 1.00 65.51  ? 129 LYS C N   1 
ATOM   5363 C CA  . LYS C 3 129 ? 156.664 227.765 331.561 1.00 64.89  ? 129 LYS C CA  1 
ATOM   5364 C C   . LYS C 3 129 ? 156.727 229.182 332.102 1.00 62.79  ? 129 LYS C C   1 
ATOM   5365 O O   . LYS C 3 129 ? 156.122 229.501 333.127 1.00 68.30  ? 129 LYS C O   1 
ATOM   5366 C CB  . LYS C 3 129 ? 155.590 227.653 330.477 1.00 62.27  ? 129 LYS C CB  1 
ATOM   5367 C CG  . LYS C 3 129 ? 155.452 226.253 329.916 1.00 61.12  ? 129 LYS C CG  1 
ATOM   5368 C CD  . LYS C 3 129 ? 154.674 226.239 328.622 1.00 63.27  ? 129 LYS C CD  1 
ATOM   5369 C CE  . LYS C 3 129 ? 154.565 224.833 328.074 1.00 61.07  ? 129 LYS C CE  1 
ATOM   5370 N NZ  . LYS C 3 129 ? 154.160 224.838 326.649 1.00 67.23  ? 129 LYS C NZ  1 
ATOM   5371 N N   . LEU C 3 130 ? 157.475 230.026 331.399 1.00 58.26  ? 130 LEU C N   1 
ATOM   5372 C CA  . LEU C 3 130 ? 157.641 231.418 331.785 1.00 59.59  ? 130 LEU C CA  1 
ATOM   5373 C C   . LEU C 3 130 ? 157.535 232.286 330.545 1.00 59.18  ? 130 LEU C C   1 
ATOM   5374 O O   . LEU C 3 130 ? 157.706 231.818 329.421 1.00 65.81  ? 130 LEU C O   1 
ATOM   5375 C CB  . LEU C 3 130 ? 158.982 231.650 332.488 1.00 61.44  ? 130 LEU C CB  1 
ATOM   5376 C CG  . LEU C 3 130 ? 159.210 230.802 333.736 1.00 62.60  ? 130 LEU C CG  1 
ATOM   5377 C CD1 . LEU C 3 130 ? 160.642 230.945 334.207 1.00 59.64  ? 130 LEU C CD1 1 
ATOM   5378 C CD2 . LEU C 3 130 ? 158.241 231.208 334.827 1.00 64.68  ? 130 LEU C CD2 1 
ATOM   5379 N N   . LEU C 3 131 ? 157.224 233.558 330.757 1.00 53.22  ? 131 LEU C N   1 
ATOM   5380 C CA  . LEU C 3 131 ? 157.161 234.541 329.684 1.00 54.21  ? 131 LEU C CA  1 
ATOM   5381 C C   . LEU C 3 131 ? 158.207 235.608 329.958 1.00 61.60  ? 131 LEU C C   1 
ATOM   5382 O O   . LEU C 3 131 ? 158.138 236.298 330.980 1.00 68.09  ? 131 LEU C O   1 
ATOM   5383 C CB  . LEU C 3 131 ? 155.762 235.153 329.585 1.00 56.17  ? 131 LEU C CB  1 
ATOM   5384 C CG  . LEU C 3 131 ? 155.572 236.312 328.604 1.00 57.94  ? 131 LEU C CG  1 
ATOM   5385 C CD1 . LEU C 3 131 ? 154.205 236.242 327.958 1.00 60.58  ? 131 LEU C CD1 1 
ATOM   5386 C CD2 . LEU C 3 131 ? 155.745 237.649 329.303 1.00 56.20  ? 131 LEU C CD2 1 
ATOM   5387 N N   . VAL C 3 132 ? 159.176 235.732 329.056 1.00 52.57  ? 132 VAL C N   1 
ATOM   5388 C CA  . VAL C 3 132 ? 160.241 236.721 329.156 1.00 51.66  ? 132 VAL C CA  1 
ATOM   5389 C C   . VAL C 3 132 ? 159.940 237.788 328.116 1.00 54.00  ? 132 VAL C C   1 
ATOM   5390 O O   . VAL C 3 132 ? 159.983 237.518 326.911 1.00 62.73  ? 132 VAL C O   1 
ATOM   5391 C CB  . VAL C 3 132 ? 161.623 236.092 328.935 1.00 50.68  ? 132 VAL C CB  1 
ATOM   5392 C CG1 . VAL C 3 132 ? 162.730 237.118 329.143 1.00 55.91  ? 132 VAL C CG1 1 
ATOM   5393 C CG2 . VAL C 3 132 ? 161.815 234.909 329.869 1.00 47.69  ? 132 VAL C CG2 1 
ATOM   5394 N N   . SER C 3 133 ? 159.631 238.997 328.572 1.00 47.37  ? 133 SER C N   1 
ATOM   5395 C CA  . SER C 3 133 ? 159.108 240.047 327.715 1.00 48.62  ? 133 SER C CA  1 
ATOM   5396 C C   . SER C 3 133 ? 160.020 241.263 327.739 1.00 46.61  ? 133 SER C C   1 
ATOM   5397 O O   . SER C 3 133 ? 160.538 241.645 328.791 1.00 50.21  ? 133 SER C O   1 
ATOM   5398 C CB  . SER C 3 133 ? 157.702 240.455 328.152 1.00 55.15  ? 133 SER C CB  1 
ATOM   5399 O OG  . SER C 3 133 ? 157.260 241.598 327.443 1.00 59.66  ? 133 SER C OG  1 
ATOM   5400 N N   . TYR C 3 134 ? 160.210 241.854 326.565 1.00 46.31  ? 134 TYR C N   1 
ATOM   5401 C CA  . TYR C 3 134 ? 160.894 243.127 326.395 1.00 48.68  ? 134 TYR C CA  1 
ATOM   5402 C C   . TYR C 3 134 ? 159.909 244.109 325.780 1.00 46.22  ? 134 TYR C C   1 
ATOM   5403 O O   . TYR C 3 134 ? 159.374 243.860 324.694 1.00 49.07  ? 134 TYR C O   1 
ATOM   5404 C CB  . TYR C 3 134 ? 162.130 242.976 325.509 1.00 48.38  ? 134 TYR C CB  1 
ATOM   5405 C CG  . TYR C 3 134 ? 162.671 244.285 324.982 1.00 44.31  ? 134 TYR C CG  1 
ATOM   5406 C CD1 . TYR C 3 134 ? 163.204 245.233 325.840 1.00 45.66  ? 134 TYR C CD1 1 
ATOM   5407 C CD2 . TYR C 3 134 ? 162.658 244.567 323.626 1.00 45.27  ? 134 TYR C CD2 1 
ATOM   5408 C CE1 . TYR C 3 134 ? 163.701 246.426 325.364 1.00 44.40  ? 134 TYR C CE1 1 
ATOM   5409 C CE2 . TYR C 3 134 ? 163.154 245.758 323.140 1.00 46.16  ? 134 TYR C CE2 1 
ATOM   5410 C CZ  . TYR C 3 134 ? 163.675 246.683 324.014 1.00 49.41  ? 134 TYR C CZ  1 
ATOM   5411 O OH  . TYR C 3 134 ? 164.170 247.873 323.536 1.00 50.80  ? 134 TYR C OH  1 
ATOM   5412 N N   . ALA C 3 135 ? 159.666 245.209 326.479 1.00 48.06  ? 135 ALA C N   1 
ATOM   5413 C CA  . ALA C 3 135 ? 158.748 246.251 326.023 1.00 46.89  ? 135 ALA C CA  1 
ATOM   5414 C C   . ALA C 3 135 ? 159.520 247.547 325.830 1.00 48.86  ? 135 ALA C C   1 
ATOM   5415 O O   . ALA C 3 135 ? 160.027 248.111 326.819 1.00 58.06  ? 135 ALA C O   1 
ATOM   5416 C CB  . ALA C 3 135 ? 157.615 246.450 327.028 1.00 53.33  ? 135 ALA C CB  1 
ATOM   5417 N N   . PRO C 3 136 ? 159.654 248.058 324.609 1.00 39.56  ? 136 PRO C N   1 
ATOM   5418 C CA  . PRO C 3 136 ? 160.371 249.319 324.408 1.00 43.43  ? 136 PRO C CA  1 
ATOM   5419 C C   . PRO C 3 136 ? 159.769 250.432 325.245 1.00 45.56  ? 136 PRO C C   1 
ATOM   5420 O O   . PRO C 3 136 ? 158.667 250.284 325.794 1.00 44.39  ? 136 PRO C O   1 
ATOM   5421 C CB  . PRO C 3 136 ? 160.197 249.586 322.908 1.00 35.32  ? 136 PRO C CB  1 
ATOM   5422 C CG  . PRO C 3 136 ? 160.048 248.240 322.318 1.00 37.69  ? 136 PRO C CG  1 
ATOM   5423 C CD  . PRO C 3 136 ? 159.290 247.432 323.327 1.00 34.81  ? 136 PRO C CD  1 
ATOM   5424 N N   . PRO C 3 137 ? 160.457 251.557 325.371 1.00 50.01  ? 137 PRO C N   1 
ATOM   5425 C CA  . PRO C 3 137 ? 159.996 252.630 326.254 1.00 51.18  ? 137 PRO C CA  1 
ATOM   5426 C C   . PRO C 3 137 ? 158.882 253.440 325.601 1.00 50.65  ? 137 PRO C C   1 
ATOM   5427 O O   . PRO C 3 137 ? 158.478 253.194 324.468 1.00 52.34  ? 137 PRO C O   1 
ATOM   5428 C CB  . PRO C 3 137 ? 161.257 253.467 326.461 1.00 51.63  ? 137 PRO C CB  1 
ATOM   5429 C CG  . PRO C 3 137 ? 162.011 253.298 325.195 1.00 56.30  ? 137 PRO C CG  1 
ATOM   5430 C CD  . PRO C 3 137 ? 161.725 251.902 324.706 1.00 52.07  ? 137 PRO C CD  1 
ATOM   5431 N N   . GLY C 3 138 ? 158.390 254.424 326.346 1.00 56.48  ? 138 GLY C N   1 
ATOM   5432 C CA  . GLY C 3 138 ? 157.365 255.319 325.860 1.00 59.18  ? 138 GLY C CA  1 
ATOM   5433 C C   . GLY C 3 138 ? 155.959 255.021 326.327 1.00 61.97  ? 138 GLY C C   1 
ATOM   5434 O O   . GLY C 3 138 ? 155.024 255.682 325.864 1.00 64.12  ? 138 GLY C O   1 
ATOM   5435 N N   . ALA C 3 139 ? 155.776 254.053 327.221 1.00 68.01  ? 139 ALA C N   1 
ATOM   5436 C CA  . ALA C 3 139 ? 154.453 253.708 327.719 1.00 66.07  ? 139 ALA C CA  1 
ATOM   5437 C C   . ALA C 3 139 ? 154.578 253.242 329.162 1.00 66.48  ? 139 ALA C C   1 
ATOM   5438 O O   . ALA C 3 139 ? 155.668 253.228 329.740 1.00 71.31  ? 139 ALA C O   1 
ATOM   5439 C CB  . ALA C 3 139 ? 153.799 252.634 326.850 1.00 66.82  ? 139 ALA C CB  1 
ATOM   5440 N N   . ASP C 3 140 ? 153.448 252.860 329.742 1.00 67.54  ? 140 ASP C N   1 
ATOM   5441 C CA  . ASP C 3 140 ? 153.456 252.339 331.098 1.00 68.00  ? 140 ASP C CA  1 
ATOM   5442 C C   . ASP C 3 140 ? 154.325 251.086 331.158 1.00 67.98  ? 140 ASP C C   1 
ATOM   5443 O O   . ASP C 3 140 ? 154.176 250.197 330.308 1.00 66.07  ? 140 ASP C O   1 
ATOM   5444 C CB  . ASP C 3 140 ? 152.035 252.010 331.554 1.00 70.81  ? 140 ASP C CB  1 
ATOM   5445 C CG  . ASP C 3 140 ? 151.238 253.245 331.920 1.00 73.67  ? 140 ASP C CG  1 
ATOM   5446 O OD1 . ASP C 3 140 ? 151.808 254.156 332.558 1.00 75.71  ? 140 ASP C OD1 1 
ATOM   5447 O OD2 . ASP C 3 140 ? 150.041 253.305 331.572 1.00 72.13  ? 140 ASP C OD2 1 
ATOM   5448 N N   . PRO C 3 141 ? 155.238 250.975 332.118 1.00 63.31  ? 141 PRO C N   1 
ATOM   5449 C CA  . PRO C 3 141 ? 155.996 249.733 332.268 1.00 59.13  ? 141 PRO C CA  1 
ATOM   5450 C C   . PRO C 3 141 ? 155.062 248.566 332.524 1.00 66.20  ? 141 PRO C C   1 
ATOM   5451 O O   . PRO C 3 141 ? 154.069 248.709 333.253 1.00 66.32  ? 141 PRO C O   1 
ATOM   5452 C CB  . PRO C 3 141 ? 156.892 250.008 333.484 1.00 58.99  ? 141 PRO C CB  1 
ATOM   5453 C CG  . PRO C 3 141 ? 157.003 251.481 333.548 1.00 60.44  ? 141 PRO C CG  1 
ATOM   5454 C CD  . PRO C 3 141 ? 155.695 252.012 333.057 1.00 63.64  ? 141 PRO C CD  1 
ATOM   5455 N N   . PRO C 3 142 ? 155.331 247.396 331.944 1.00 66.11  ? 142 PRO C N   1 
ATOM   5456 C CA  . PRO C 3 142 ? 154.476 246.239 332.224 1.00 59.18  ? 142 PRO C CA  1 
ATOM   5457 C C   . PRO C 3 142 ? 154.462 245.903 333.708 1.00 59.77  ? 142 PRO C C   1 
ATOM   5458 O O   . PRO C 3 142 ? 155.492 245.933 334.383 1.00 61.83  ? 142 PRO C O   1 
ATOM   5459 C CB  . PRO C 3 142 ? 155.114 245.117 331.399 1.00 54.82  ? 142 PRO C CB  1 
ATOM   5460 C CG  . PRO C 3 142 ? 155.856 245.809 330.324 1.00 56.92  ? 142 PRO C CG  1 
ATOM   5461 C CD  . PRO C 3 142 ? 156.343 247.092 330.918 1.00 60.35  ? 142 PRO C CD  1 
ATOM   5462 N N   . LYS C 3 143 ? 153.274 245.578 334.209 1.00 66.58  ? 143 LYS C N   1 
ATOM   5463 C CA  . LYS C 3 143 ? 153.105 245.117 335.577 1.00 70.42  ? 143 LYS C CA  1 
ATOM   5464 C C   . LYS C 3 143 ? 152.233 243.875 335.666 1.00 73.41  ? 143 LYS C C   1 
ATOM   5465 O O   . LYS C 3 143 ? 152.078 243.323 336.760 1.00 71.04  ? 143 LYS C O   1 
ATOM   5466 C CB  . LYS C 3 143 ? 152.498 246.226 336.450 1.00 70.20  ? 143 LYS C CB  1 
ATOM   5467 C CG  . LYS C 3 143 ? 153.461 247.349 336.796 1.00 69.01  ? 143 LYS C CG  1 
ATOM   5468 C CD  . LYS C 3 143 ? 154.555 246.874 337.739 1.00 69.51  ? 143 LYS C CD  1 
ATOM   5469 C CE  . LYS C 3 143 ? 155.456 248.015 338.170 1.00 72.69  ? 143 LYS C CE  1 
ATOM   5470 N NZ  . LYS C 3 143 ? 156.545 247.545 339.068 1.00 72.21  ? 143 LYS C NZ  1 
ATOM   5471 N N   . LYS C 3 144 ? 151.654 243.431 334.554 1.00 77.30  ? 144 LYS C N   1 
ATOM   5472 C CA  . LYS C 3 144 ? 150.875 242.208 334.500 1.00 72.43  ? 144 LYS C CA  1 
ATOM   5473 C C   . LYS C 3 144 ? 151.192 241.509 333.188 1.00 72.52  ? 144 LYS C C   1 
ATOM   5474 O O   . LYS C 3 144 ? 151.625 242.138 332.220 1.00 77.73  ? 144 LYS C O   1 
ATOM   5475 C CB  . LYS C 3 144 ? 149.369 242.486 334.599 1.00 70.74  ? 144 LYS C CB  1 
ATOM   5476 C CG  . LYS C 3 144 ? 148.971 243.404 335.745 1.00 74.26  ? 144 LYS C CG  1 
ATOM   5477 C CD  . LYS C 3 144 ? 149.116 242.727 337.099 1.00 80.09  ? 144 LYS C CD  1 
ATOM   5478 C CE  . LYS C 3 144 ? 147.968 241.768 337.369 1.00 80.56  ? 144 LYS C CE  1 
ATOM   5479 N NZ  . LYS C 3 144 ? 148.103 241.094 338.689 1.00 77.76  ? 144 LYS C NZ  1 
ATOM   5480 N N   . ARG C 3 145 ? 150.974 240.195 333.157 1.00 64.32  ? 145 ARG C N   1 
ATOM   5481 C CA  . ARG C 3 145 ? 151.197 239.463 331.918 1.00 65.97  ? 145 ARG C CA  1 
ATOM   5482 C C   . ARG C 3 145 ? 150.318 239.988 330.794 1.00 67.06  ? 145 ARG C C   1 
ATOM   5483 O O   . ARG C 3 145 ? 150.654 239.804 329.620 1.00 64.44  ? 145 ARG C O   1 
ATOM   5484 C CB  . ARG C 3 145 ? 150.941 237.971 332.128 1.00 65.97  ? 145 ARG C CB  1 
ATOM   5485 C CG  . ARG C 3 145 ? 151.520 237.092 331.033 1.00 62.63  ? 145 ARG C CG  1 
ATOM   5486 C CD  . ARG C 3 145 ? 151.084 235.648 331.191 1.00 61.52  ? 145 ARG C CD  1 
ATOM   5487 N NE  . ARG C 3 145 ? 149.670 235.472 330.884 1.00 66.27  ? 145 ARG C NE  1 
ATOM   5488 C CZ  . ARG C 3 145 ? 148.996 234.345 331.067 1.00 70.34  ? 145 ARG C CZ  1 
ATOM   5489 N NH1 . ARG C 3 145 ? 149.570 233.271 331.579 1.00 68.40  ? 145 ARG C NH1 1 
ATOM   5490 N NH2 . ARG C 3 145 ? 147.711 234.297 330.730 1.00 74.40  ? 145 ARG C NH2 1 
ATOM   5491 N N   . LYS C 3 146 ? 149.208 240.649 331.130 1.00 71.48  ? 146 LYS C N   1 
ATOM   5492 C CA  . LYS C 3 146 ? 148.312 241.172 330.105 1.00 71.90  ? 146 LYS C CA  1 
ATOM   5493 C C   . LYS C 3 146 ? 149.021 242.188 329.220 1.00 74.18  ? 146 LYS C C   1 
ATOM   5494 O O   . LYS C 3 146 ? 148.821 242.207 328.000 1.00 72.73  ? 146 LYS C O   1 
ATOM   5495 C CB  . LYS C 3 146 ? 147.088 241.807 330.763 1.00 68.93  ? 146 LYS C CB  1 
ATOM   5496 C CG  . LYS C 3 146 ? 145.951 242.115 329.802 1.00 69.62  ? 146 LYS C CG  1 
ATOM   5497 C CD  . LYS C 3 146 ? 145.098 240.890 329.510 1.00 72.56  ? 146 LYS C CD  1 
ATOM   5498 C CE  . LYS C 3 146 ? 144.296 240.462 330.731 1.00 72.93  ? 146 LYS C CE  1 
ATOM   5499 N NZ  . LYS C 3 146 ? 143.219 239.493 330.391 1.00 73.47  ? 146 LYS C NZ  1 
ATOM   5500 N N   . GLU C 3 147 ? 149.845 243.047 329.816 1.00 75.64  ? 147 GLU C N   1 
ATOM   5501 C CA  . GLU C 3 147 ? 150.505 244.116 329.078 1.00 70.50  ? 147 GLU C CA  1 
ATOM   5502 C C   . GLU C 3 147 ? 151.859 243.705 328.522 1.00 65.11  ? 147 GLU C C   1 
ATOM   5503 O O   . GLU C 3 147 ? 152.297 244.260 327.509 1.00 64.82  ? 147 GLU C O   1 
ATOM   5504 C CB  . GLU C 3 147 ? 150.683 245.338 329.981 1.00 70.79  ? 147 GLU C CB  1 
ATOM   5505 C CG  . GLU C 3 147 ? 149.388 245.857 330.576 1.00 74.25  ? 147 GLU C CG  1 
ATOM   5506 C CD  . GLU C 3 147 ? 149.605 247.018 331.524 1.00 79.87  ? 147 GLU C CD  1 
ATOM   5507 O OE1 . GLU C 3 147 ? 150.773 247.295 331.869 1.00 82.77  ? 147 GLU C OE1 1 
ATOM   5508 O OE2 . GLU C 3 147 ? 148.609 247.656 331.924 1.00 77.98  ? 147 GLU C OE2 1 
ATOM   5509 N N   . ALA C 3 148 ? 152.533 242.748 329.159 1.00 60.87  ? 148 ALA C N   1 
ATOM   5510 C CA  . ALA C 3 148 ? 153.878 242.386 328.727 1.00 66.31  ? 148 ALA C CA  1 
ATOM   5511 C C   . ALA C 3 148 ? 153.864 241.688 327.374 1.00 63.29  ? 148 ALA C C   1 
ATOM   5512 O O   . ALA C 3 148 ? 154.746 241.923 326.541 1.00 61.94  ? 148 ALA C O   1 
ATOM   5513 C CB  . ALA C 3 148 ? 154.541 241.499 329.779 1.00 70.20  ? 148 ALA C CB  1 
ATOM   5514 N N   . MET C 3 149 ? 152.874 240.825 327.135 1.00 66.66  ? 149 MET C N   1 
ATOM   5515 C CA  . MET C 3 149 ? 152.852 240.056 325.896 1.00 63.19  ? 149 MET C CA  1 
ATOM   5516 C C   . MET C 3 149 ? 152.805 240.962 324.675 1.00 68.19  ? 149 MET C C   1 
ATOM   5517 O O   . MET C 3 149 ? 153.302 240.590 323.607 1.00 63.44  ? 149 MET C O   1 
ATOM   5518 C CB  . MET C 3 149 ? 151.652 239.111 325.886 1.00 59.77  ? 149 MET C CB  1 
ATOM   5519 C CG  . MET C 3 149 ? 150.379 239.747 325.357 1.00 65.33  ? 149 MET C CG  1 
ATOM   5520 S SD  . MET C 3 149 ? 148.898 238.792 325.707 1.00 72.44  ? 149 MET C SD  1 
ATOM   5521 C CE  . MET C 3 149 ? 148.844 238.935 327.486 1.00 71.37  ? 149 MET C CE  1 
ATOM   5522 N N   . LEU C 3 150 ? 152.211 242.149 324.808 1.00 67.27  ? 150 LEU C N   1 
ATOM   5523 C CA  . LEU C 3 150 ? 152.029 243.015 323.650 1.00 60.12  ? 150 LEU C CA  1 
ATOM   5524 C C   . LEU C 3 150 ? 153.362 243.444 323.054 1.00 66.59  ? 150 LEU C C   1 
ATOM   5525 O O   . LEU C 3 150 ? 153.442 243.722 321.853 1.00 72.21  ? 150 LEU C O   1 
ATOM   5526 C CB  . LEU C 3 150 ? 151.196 244.232 324.041 1.00 62.54  ? 150 LEU C CB  1 
ATOM   5527 C CG  . LEU C 3 150 ? 149.797 243.897 324.560 1.00 64.02  ? 150 LEU C CG  1 
ATOM   5528 C CD1 . LEU C 3 150 ? 149.099 245.140 325.081 1.00 63.33  ? 150 LEU C CD1 1 
ATOM   5529 C CD2 . LEU C 3 150 ? 148.965 243.234 323.474 1.00 63.23  ? 150 LEU C CD2 1 
ATOM   5530 N N   . GLY C 3 151 ? 154.412 243.507 323.866 1.00 64.37  ? 151 GLY C N   1 
ATOM   5531 C CA  . GLY C 3 151 ? 155.744 243.761 323.365 1.00 58.62  ? 151 GLY C CA  1 
ATOM   5532 C C   . GLY C 3 151 ? 156.394 242.485 322.872 1.00 57.79  ? 151 GLY C C   1 
ATOM   5533 O O   . GLY C 3 151 ? 155.750 241.454 322.671 1.00 64.65  ? 151 GLY C O   1 
ATOM   5534 N N   . THR C 3 152 ? 157.705 242.564 322.664 1.00 58.69  ? 152 THR C N   1 
ATOM   5535 C CA  . THR C 3 152 ? 158.459 241.362 322.341 1.00 60.89  ? 152 THR C CA  1 
ATOM   5536 C C   . THR C 3 152 ? 158.365 240.390 323.504 1.00 60.21  ? 152 THR C C   1 
ATOM   5537 O O   . THR C 3 152 ? 158.374 240.795 324.666 1.00 68.60  ? 152 THR C O   1 
ATOM   5538 C CB  . THR C 3 152 ? 159.919 241.707 322.055 1.00 50.30  ? 152 THR C CB  1 
ATOM   5539 O OG1 . THR C 3 152 ? 159.994 242.570 320.916 1.00 52.63  ? 152 THR C OG1 1 
ATOM   5540 C CG2 . THR C 3 152 ? 160.726 240.448 321.789 1.00 51.95  ? 152 THR C CG2 1 
ATOM   5541 N N   . HIS C 3 153 ? 158.258 239.102 323.201 1.00 42.58  ? 153 HIS C N   1 
ATOM   5542 C CA  . HIS C 3 153 ? 158.184 238.131 324.279 1.00 45.83  ? 153 HIS C CA  1 
ATOM   5543 C C   . HIS C 3 153 ? 158.591 236.764 323.759 1.00 52.50  ? 153 HIS C C   1 
ATOM   5544 O O   . HIS C 3 153 ? 158.506 236.474 322.564 1.00 54.81  ? 153 HIS C O   1 
ATOM   5545 C CB  . HIS C 3 153 ? 156.784 238.085 324.899 1.00 46.95  ? 153 HIS C CB  1 
ATOM   5546 C CG  . HIS C 3 153 ? 155.725 237.579 323.973 1.00 53.01  ? 153 HIS C CG  1 
ATOM   5547 N ND1 . HIS C 3 153 ? 155.205 236.306 324.062 1.00 50.38  ? 153 HIS C ND1 1 
ATOM   5548 C CD2 . HIS C 3 153 ? 155.082 238.176 322.942 1.00 51.52  ? 153 HIS C CD2 1 
ATOM   5549 C CE1 . HIS C 3 153 ? 154.289 236.141 323.125 1.00 46.66  ? 153 HIS C CE1 1 
ATOM   5550 N NE2 . HIS C 3 153 ? 154.195 237.260 322.432 1.00 46.82  ? 153 HIS C NE2 1 
ATOM   5551 N N   . VAL C 3 154 ? 159.049 235.936 324.689 1.00 54.45  ? 154 VAL C N   1 
ATOM   5552 C CA  . VAL C 3 154 ? 159.464 234.570 324.413 1.00 46.59  ? 154 VAL C CA  1 
ATOM   5553 C C   . VAL C 3 154 ? 158.905 233.691 325.516 1.00 51.72  ? 154 VAL C C   1 
ATOM   5554 O O   . VAL C 3 154 ? 158.965 234.047 326.697 1.00 58.92  ? 154 VAL C O   1 
ATOM   5555 C CB  . VAL C 3 154 ? 160.999 234.446 324.335 1.00 44.67  ? 154 VAL C CB  1 
ATOM   5556 C CG1 . VAL C 3 154 ? 161.407 233.010 324.074 1.00 42.83  ? 154 VAL C CG1 1 
ATOM   5557 C CG2 . VAL C 3 154 ? 161.549 235.365 323.258 1.00 60.25  ? 154 VAL C CG2 1 
ATOM   5558 N N   . ILE C 3 155 ? 158.345 232.552 325.132 1.00 54.17  ? 155 ILE C N   1 
ATOM   5559 C CA  . ILE C 3 155 ? 157.782 231.606 326.084 1.00 49.55  ? 155 ILE C CA  1 
ATOM   5560 C C   . ILE C 3 155 ? 158.805 230.506 326.313 1.00 46.71  ? 155 ILE C C   1 
ATOM   5561 O O   . ILE C 3 155 ? 159.129 229.739 325.400 1.00 54.15  ? 155 ILE C O   1 
ATOM   5562 C CB  . ILE C 3 155 ? 156.444 231.043 325.591 1.00 51.61  ? 155 ILE C CB  1 
ATOM   5563 C CG1 . ILE C 3 155 ? 155.368 232.127 325.718 1.00 52.21  ? 155 ILE C CG1 1 
ATOM   5564 C CG2 . ILE C 3 155 ? 156.078 229.807 326.399 1.00 50.94  ? 155 ILE C CG2 1 
ATOM   5565 C CD1 . ILE C 3 155 ? 154.275 232.070 324.677 1.00 51.34  ? 155 ILE C CD1 1 
ATOM   5566 N N   . TRP C 3 156 ? 159.300 230.427 327.540 1.00 53.50  ? 156 TRP C N   1 
ATOM   5567 C CA  . TRP C 3 156 ? 160.370 229.523 327.922 1.00 59.36  ? 156 TRP C CA  1 
ATOM   5568 C C   . TRP C 3 156 ? 159.760 228.287 328.558 1.00 64.31  ? 156 TRP C C   1 
ATOM   5569 O O   . TRP C 3 156 ? 159.064 228.390 329.573 1.00 62.42  ? 156 TRP C O   1 
ATOM   5570 C CB  . TRP C 3 156 ? 161.311 230.223 328.901 1.00 61.01  ? 156 TRP C CB  1 
ATOM   5571 C CG  . TRP C 3 156 ? 162.351 229.351 329.531 1.00 64.78  ? 156 TRP C CG  1 
ATOM   5572 C CD1 . TRP C 3 156 ? 162.811 228.149 329.081 1.00 61.27  ? 156 TRP C CD1 1 
ATOM   5573 C CD2 . TRP C 3 156 ? 163.065 229.626 330.739 1.00 63.79  ? 156 TRP C CD2 1 
ATOM   5574 N NE1 . TRP C 3 156 ? 163.770 227.661 329.933 1.00 60.61  ? 156 TRP C NE1 1 
ATOM   5575 C CE2 . TRP C 3 156 ? 163.942 228.550 330.961 1.00 64.25  ? 156 TRP C CE2 1 
ATOM   5576 C CE3 . TRP C 3 156 ? 163.047 230.680 331.656 1.00 58.15  ? 156 TRP C CE3 1 
ATOM   5577 C CZ2 . TRP C 3 156 ? 164.791 228.497 332.059 1.00 66.62  ? 156 TRP C CZ2 1 
ATOM   5578 C CZ3 . TRP C 3 156 ? 163.888 230.624 332.744 1.00 58.32  ? 156 TRP C CZ3 1 
ATOM   5579 C CH2 . TRP C 3 156 ? 164.749 229.542 332.937 1.00 62.12  ? 156 TRP C CH2 1 
ATOM   5580 N N   . ASP C 3 157 ? 160.028 227.126 327.966 1.00 67.70  ? 157 ASP C N   1 
ATOM   5581 C CA  . ASP C 3 157 ? 159.620 225.853 328.537 1.00 64.57  ? 157 ASP C CA  1 
ATOM   5582 C C   . ASP C 3 157 ? 160.756 225.310 329.389 1.00 68.65  ? 157 ASP C C   1 
ATOM   5583 O O   . ASP C 3 157 ? 161.892 225.200 328.920 1.00 70.94  ? 157 ASP C O   1 
ATOM   5584 C CB  . ASP C 3 157 ? 159.259 224.851 327.445 1.00 64.08  ? 157 ASP C CB  1 
ATOM   5585 C CG  . ASP C 3 157 ? 158.526 223.642 327.988 1.00 70.92  ? 157 ASP C CG  1 
ATOM   5586 O OD1 . ASP C 3 157 ? 158.728 223.312 329.175 1.00 73.70  ? 157 ASP C OD1 1 
ATOM   5587 O OD2 . ASP C 3 157 ? 157.745 223.023 327.234 1.00 71.41  ? 157 ASP C OD2 1 
ATOM   5588 N N   . ILE C 3 158 ? 160.444 224.966 330.631 1.00 72.29  ? 158 ILE C N   1 
ATOM   5589 C CA  . ILE C 3 158 ? 161.441 224.509 331.581 1.00 70.44  ? 158 ILE C CA  1 
ATOM   5590 C C   . ILE C 3 158 ? 161.494 222.981 331.640 1.00 71.17  ? 158 ILE C C   1 
ATOM   5591 O O   . ILE C 3 158 ? 161.909 222.416 332.650 1.00 72.47  ? 158 ILE C O   1 
ATOM   5592 C CB  . ILE C 3 158 ? 161.195 225.105 332.974 1.00 70.06  ? 158 ILE C CB  1 
ATOM   5593 C CG1 . ILE C 3 158 ? 160.663 226.537 332.866 1.00 72.77  ? 158 ILE C CG1 1 
ATOM   5594 C CG2 . ILE C 3 158 ? 162.469 225.094 333.785 1.00 71.53  ? 158 ILE C CG2 1 
ATOM   5595 C CD1 . ILE C 3 158 ? 160.729 227.303 334.169 1.00 74.44  ? 158 ILE C CD1 1 
ATOM   5596 N N   . GLY C 3 159 ? 161.078 222.302 330.571 1.00 75.89  ? 159 GLY C N   1 
ATOM   5597 C CA  . GLY C 3 159 ? 161.004 220.852 330.622 1.00 77.72  ? 159 GLY C CA  1 
ATOM   5598 C C   . GLY C 3 159 ? 162.364 220.195 330.758 1.00 83.21  ? 159 GLY C C   1 
ATOM   5599 O O   . GLY C 3 159 ? 162.676 219.604 331.796 1.00 86.52  ? 159 GLY C O   1 
ATOM   5600 N N   . LEU C 3 160 ? 163.199 220.295 329.722 1.00 81.14  ? 160 LEU C N   1 
ATOM   5601 C CA  . LEU C 3 160 ? 164.477 219.592 329.743 1.00 81.83  ? 160 LEU C CA  1 
ATOM   5602 C C   . LEU C 3 160 ? 165.663 220.543 329.689 1.00 85.66  ? 160 LEU C C   1 
ATOM   5603 O O   . LEU C 3 160 ? 166.527 220.513 330.571 1.00 82.66  ? 160 LEU C O   1 
ATOM   5604 C CB  . LEU C 3 160 ? 164.554 218.613 328.574 1.00 81.20  ? 160 LEU C CB  1 
ATOM   5605 C CG  . LEU C 3 160 ? 165.836 217.784 328.539 1.00 81.45  ? 160 LEU C CG  1 
ATOM   5606 C CD1 . LEU C 3 160 ? 165.512 216.333 328.238 1.00 79.41  ? 160 LEU C CD1 1 
ATOM   5607 C CD2 . LEU C 3 160 ? 166.818 218.347 327.519 1.00 78.10  ? 160 LEU C CD2 1 
ATOM   5608 N N   . GLN C 3 161 ? 165.716 221.388 328.663 1.00 90.22  ? 161 GLN C N   1 
ATOM   5609 C CA  . GLN C 3 161 ? 166.777 222.379 328.584 1.00 86.00  ? 161 GLN C CA  1 
ATOM   5610 C C   . GLN C 3 161 ? 166.587 223.406 329.690 1.00 86.33  ? 161 GLN C C   1 
ATOM   5611 O O   . GLN C 3 161 ? 165.479 223.902 329.911 1.00 86.34  ? 161 GLN C O   1 
ATOM   5612 C CB  . GLN C 3 161 ? 166.782 223.053 327.210 1.00 83.61  ? 161 GLN C CB  1 
ATOM   5613 C CG  . GLN C 3 161 ? 167.083 222.108 326.048 1.00 83.55  ? 161 GLN C CG  1 
ATOM   5614 C CD  . GLN C 3 161 ? 168.568 221.893 325.830 1.00 86.77  ? 161 GLN C CD  1 
ATOM   5615 O OE1 . GLN C 3 161 ? 169.256 221.324 326.677 1.00 88.19  ? 161 GLN C OE1 1 
ATOM   5616 N NE2 . GLN C 3 161 ? 169.070 222.348 324.687 1.00 88.17  ? 161 GLN C NE2 1 
ATOM   5617 N N   . SER C 3 162 ? 167.670 223.720 330.389 1.00 65.24  ? 162 SER C N   1 
ATOM   5618 C CA  . SER C 3 162 ? 167.609 224.587 331.553 1.00 63.44  ? 162 SER C CA  1 
ATOM   5619 C C   . SER C 3 162 ? 167.720 226.059 331.201 1.00 65.04  ? 162 SER C C   1 
ATOM   5620 O O   . SER C 3 162 ? 167.622 226.896 332.102 1.00 68.72  ? 162 SER C O   1 
ATOM   5621 C CB  . SER C 3 162 ? 168.719 224.217 332.534 1.00 65.93  ? 162 SER C CB  1 
ATOM   5622 O OG  . SER C 3 162 ? 169.992 224.364 331.930 1.00 65.66  ? 162 SER C OG  1 
ATOM   5623 N N   . SER C 3 163 ? 167.893 226.400 329.925 1.00 57.31  ? 163 SER C N   1 
ATOM   5624 C CA  . SER C 3 163 ? 168.236 227.765 329.558 1.00 56.07  ? 163 SER C CA  1 
ATOM   5625 C C   . SER C 3 163 ? 167.324 228.271 328.449 1.00 54.52  ? 163 SER C C   1 
ATOM   5626 O O   . SER C 3 163 ? 166.742 227.496 327.688 1.00 63.66  ? 163 SER C O   1 
ATOM   5627 C CB  . SER C 3 163 ? 169.702 227.870 329.123 1.00 62.01  ? 163 SER C CB  1 
ATOM   5628 O OG  . SER C 3 163 ? 170.566 227.445 330.163 1.00 64.00  ? 163 SER C OG  1 
ATOM   5629 N N   . CYS C 3 164 ? 167.204 229.598 328.384 1.00 52.92  ? 164 CYS C N   1 
ATOM   5630 C CA  . CYS C 3 164 ? 166.430 230.271 327.344 1.00 53.98  ? 164 CYS C CA  1 
ATOM   5631 C C   . CYS C 3 164 ? 167.079 231.605 327.022 1.00 57.87  ? 164 CYS C C   1 
ATOM   5632 O O   . CYS C 3 164 ? 167.485 232.327 327.936 1.00 64.10  ? 164 CYS C O   1 
ATOM   5633 C CB  . CYS C 3 164 ? 164.981 230.510 327.772 1.00 56.86  ? 164 CYS C CB  1 
ATOM   5634 S SG  . CYS C 3 164 ? 163.952 231.172 326.439 1.00 68.60  ? 164 CYS C SG  1 
ATOM   5635 N N   . THR C 3 165 ? 167.159 231.932 325.734 1.00 57.29  ? 165 THR C N   1 
ATOM   5636 C CA  . THR C 3 165 ? 167.773 233.165 325.259 1.00 57.30  ? 165 THR C CA  1 
ATOM   5637 C C   . THR C 3 165 ? 166.717 234.094 324.675 1.00 54.36  ? 165 THR C C   1 
ATOM   5638 O O   . THR C 3 165 ? 165.944 233.690 323.802 1.00 57.17  ? 165 THR C O   1 
ATOM   5639 C CB  . THR C 3 165 ? 168.833 232.862 324.201 1.00 55.12  ? 165 THR C CB  1 
ATOM   5640 O OG1 . THR C 3 165 ? 169.666 231.790 324.653 1.00 58.75  ? 165 THR C OG1 1 
ATOM   5641 C CG2 . THR C 3 165 ? 169.693 234.082 323.938 1.00 55.14  ? 165 THR C CG2 1 
ATOM   5642 N N   . MET C 3 166 ? 166.698 235.338 325.150 1.00 54.50  ? 166 MET C N   1 
ATOM   5643 C CA  . MET C 3 166 ? 165.884 236.413 324.594 1.00 53.39  ? 166 MET C CA  1 
ATOM   5644 C C   . MET C 3 166 ? 166.851 237.416 323.978 1.00 55.04  ? 166 MET C C   1 
ATOM   5645 O O   . MET C 3 166 ? 167.634 238.055 324.688 1.00 60.11  ? 166 MET C O   1 
ATOM   5646 C CB  . MET C 3 166 ? 165.018 237.067 325.666 1.00 54.05  ? 166 MET C CB  1 
ATOM   5647 C CG  . MET C 3 166 ? 164.197 238.244 325.153 1.00 54.36  ? 166 MET C CG  1 
ATOM   5648 S SD  . MET C 3 166 ? 163.208 239.046 326.421 1.00 77.07  ? 166 MET C SD  1 
ATOM   5649 C CE  . MET C 3 166 ? 164.505 239.740 327.438 1.00 61.37  ? 166 MET C CE  1 
ATOM   5650 N N   . VAL C 3 167 ? 166.827 237.525 322.653 1.00 48.27  ? 167 VAL C N   1 
ATOM   5651 C CA  . VAL C 3 167 ? 167.633 238.516 321.946 1.00 49.48  ? 167 VAL C CA  1 
ATOM   5652 C C   . VAL C 3 167 ? 166.845 239.823 321.939 1.00 49.44  ? 167 VAL C C   1 
ATOM   5653 O O   . VAL C 3 167 ? 165.912 239.997 321.155 1.00 54.88  ? 167 VAL C O   1 
ATOM   5654 C CB  . VAL C 3 167 ? 167.983 238.064 320.529 1.00 47.54  ? 167 VAL C CB  1 
ATOM   5655 C CG1 . VAL C 3 167 ? 169.030 238.981 319.940 1.00 48.17  ? 167 VAL C CG1 1 
ATOM   5656 C CG2 . VAL C 3 167 ? 168.474 236.634 320.538 1.00 52.63  ? 167 VAL C CG2 1 
ATOM   5657 N N   . VAL C 3 168 ? 167.235 240.754 322.800 1.00 43.46  ? 168 VAL C N   1 
ATOM   5658 C CA  . VAL C 3 168 ? 166.616 242.073 322.846 1.00 35.43  ? 168 VAL C CA  1 
ATOM   5659 C C   . VAL C 3 168 ? 167.106 242.840 321.624 1.00 45.71  ? 168 VAL C C   1 
ATOM   5660 O O   . VAL C 3 168 ? 168.290 243.210 321.566 1.00 51.42  ? 168 VAL C O   1 
ATOM   5661 C CB  . VAL C 3 168 ? 166.963 242.811 324.147 1.00 43.48  ? 168 VAL C CB  1 
ATOM   5662 C CG1 . VAL C 3 168 ? 166.245 244.136 324.200 1.00 48.84  ? 168 VAL C CG1 1 
ATOM   5663 C CG2 . VAL C 3 168 ? 166.606 241.965 325.353 1.00 41.23  ? 168 VAL C CG2 1 
ATOM   5664 N N   . PRO C 3 169 ? 166.253 243.088 320.621 1.00 50.34  ? 169 PRO C N   1 
ATOM   5665 C CA  . PRO C 3 169 ? 166.739 243.726 319.392 1.00 50.35  ? 169 PRO C CA  1 
ATOM   5666 C C   . PRO C 3 169 ? 167.116 245.179 319.608 1.00 47.92  ? 169 PRO C C   1 
ATOM   5667 O O   . PRO C 3 169 ? 166.929 245.725 320.699 1.00 50.70  ? 169 PRO C O   1 
ATOM   5668 C CB  . PRO C 3 169 ? 165.552 243.593 318.426 1.00 43.90  ? 169 PRO C CB  1 
ATOM   5669 C CG  . PRO C 3 169 ? 164.608 242.635 319.068 1.00 43.46  ? 169 PRO C CG  1 
ATOM   5670 C CD  . PRO C 3 169 ? 164.819 242.776 320.531 1.00 44.44  ? 169 PRO C CD  1 
ATOM   5671 N N   . TRP C 3 170 ? 167.653 245.814 318.569 1.00 34.29  ? 170 TRP C N   1 
ATOM   5672 C CA  . TRP C 3 170 ? 168.070 247.211 318.641 1.00 34.84  ? 170 TRP C CA  1 
ATOM   5673 C C   . TRP C 3 170 ? 166.923 248.077 318.143 1.00 37.05  ? 170 TRP C C   1 
ATOM   5674 O O   . TRP C 3 170 ? 166.772 248.319 316.947 1.00 44.15  ? 170 TRP C O   1 
ATOM   5675 C CB  . TRP C 3 170 ? 169.339 247.432 317.830 1.00 31.98  ? 170 TRP C CB  1 
ATOM   5676 C CG  . TRP C 3 170 ? 169.788 248.856 317.792 1.00 29.54  ? 170 TRP C CG  1 
ATOM   5677 C CD1 . TRP C 3 170 ? 169.928 249.640 316.688 1.00 37.91  ? 170 TRP C CD1 1 
ATOM   5678 C CD2 . TRP C 3 170 ? 170.153 249.670 318.911 1.00 32.81  ? 170 TRP C CD2 1 
ATOM   5679 N NE1 . TRP C 3 170 ? 170.360 250.890 317.047 1.00 39.42  ? 170 TRP C NE1 1 
ATOM   5680 C CE2 . TRP C 3 170 ? 170.506 250.934 318.408 1.00 35.41  ? 170 TRP C CE2 1 
ATOM   5681 C CE3 . TRP C 3 170 ? 170.217 249.452 320.287 1.00 35.10  ? 170 TRP C CE3 1 
ATOM   5682 C CZ2 . TRP C 3 170 ? 170.916 251.973 319.232 1.00 31.44  ? 170 TRP C CZ2 1 
ATOM   5683 C CZ3 . TRP C 3 170 ? 170.627 250.484 321.101 1.00 28.59  ? 170 TRP C CZ3 1 
ATOM   5684 C CH2 . TRP C 3 170 ? 170.969 251.729 320.573 1.00 26.61  ? 170 TRP C CH2 1 
ATOM   5685 N N   . ILE C 3 171 ? 166.100 248.544 319.075 1.00 36.27  ? 171 ILE C N   1 
ATOM   5686 C CA  . ILE C 3 171 ? 165.050 249.516 318.797 1.00 37.21  ? 171 ILE C CA  1 
ATOM   5687 C C   . ILE C 3 171 ? 165.487 250.829 319.425 1.00 46.12  ? 171 ILE C C   1 
ATOM   5688 O O   . ILE C 3 171 ? 165.574 250.941 320.654 1.00 45.03  ? 171 ILE C O   1 
ATOM   5689 C CB  . ILE C 3 171 ? 163.689 249.070 319.346 1.00 38.72  ? 171 ILE C CB  1 
ATOM   5690 C CG1 . ILE C 3 171 ? 163.206 247.814 318.624 1.00 46.19  ? 171 ILE C CG1 1 
ATOM   5691 C CG2 . ILE C 3 171 ? 162.674 250.194 319.206 1.00 31.38  ? 171 ILE C CG2 1 
ATOM   5692 C CD1 . ILE C 3 171 ? 161.984 247.184 319.252 1.00 43.86  ? 171 ILE C CD1 1 
ATOM   5693 N N   . SER C 3 172 ? 165.763 251.826 318.590 1.00 45.02  ? 172 SER C N   1 
ATOM   5694 C CA  . SER C 3 172 ? 166.205 253.118 319.089 1.00 37.11  ? 172 SER C CA  1 
ATOM   5695 C C   . SER C 3 172 ? 165.960 254.174 318.025 1.00 41.08  ? 172 SER C C   1 
ATOM   5696 O O   . SER C 3 172 ? 166.165 253.921 316.836 1.00 45.83  ? 172 SER C O   1 
ATOM   5697 C CB  . SER C 3 172 ? 167.688 253.089 319.467 1.00 39.64  ? 172 SER C CB  1 
ATOM   5698 O OG  . SER C 3 172 ? 168.124 254.360 319.915 1.00 41.74  ? 172 SER C OG  1 
ATOM   5699 N N   . ASN C 3 173 ? 165.517 255.352 318.462 1.00 34.32  ? 173 ASN C N   1 
ATOM   5700 C CA  . ASN C 3 173 ? 165.418 256.483 317.548 1.00 31.44  ? 173 ASN C CA  1 
ATOM   5701 C C   . ASN C 3 173 ? 166.802 257.013 317.195 1.00 40.57  ? 173 ASN C C   1 
ATOM   5702 O O   . ASN C 3 173 ? 167.093 257.288 316.026 1.00 49.24  ? 173 ASN C O   1 
ATOM   5703 C CB  . ASN C 3 173 ? 164.549 257.579 318.163 1.00 35.11  ? 173 ASN C CB  1 
ATOM   5704 C CG  . ASN C 3 173 ? 164.978 257.951 319.564 1.00 32.98  ? 173 ASN C CG  1 
ATOM   5705 O OD1 . ASN C 3 173 ? 164.786 257.187 320.507 1.00 37.72  ? 173 ASN C OD1 1 
ATOM   5706 N ND2 . ASN C 3 173 ? 165.549 259.136 319.711 1.00 36.44  ? 173 ASN C ND2 1 
ATOM   5707 N N   . THR C 3 174 ? 167.670 257.153 318.193 1.00 43.03  ? 174 THR C N   1 
ATOM   5708 C CA  . THR C 3 174 ? 169.055 257.529 317.957 1.00 34.89  ? 174 THR C CA  1 
ATOM   5709 C C   . THR C 3 174 ? 169.868 256.316 317.525 1.00 38.10  ? 174 THR C C   1 
ATOM   5710 O O   . THR C 3 174 ? 169.526 255.172 317.833 1.00 47.85  ? 174 THR C O   1 
ATOM   5711 C CB  . THR C 3 174 ? 169.672 258.134 319.217 1.00 33.79  ? 174 THR C CB  1 
ATOM   5712 O OG1 . THR C 3 174 ? 169.465 257.250 320.324 1.00 39.43  ? 174 THR C OG1 1 
ATOM   5713 C CG2 . THR C 3 174 ? 169.049 259.480 319.529 1.00 34.99  ? 174 THR C CG2 1 
ATOM   5714 N N   . THR C 3 175 ? 170.957 256.577 316.799 1.00 33.28  ? 175 THR C N   1 
ATOM   5715 C CA  . THR C 3 175 ? 171.844 255.496 316.387 1.00 37.65  ? 175 THR C CA  1 
ATOM   5716 C C   . THR C 3 175 ? 172.689 254.978 317.541 1.00 38.41  ? 175 THR C C   1 
ATOM   5717 O O   . THR C 3 175 ? 173.250 253.883 317.438 1.00 51.01  ? 175 THR C O   1 
ATOM   5718 C CB  . THR C 3 175 ? 172.758 255.959 315.255 1.00 40.05  ? 175 THR C CB  1 
ATOM   5719 O OG1 . THR C 3 175 ? 173.537 257.078 315.693 1.00 47.20  ? 175 THR C OG1 1 
ATOM   5720 C CG2 . THR C 3 175 ? 171.942 256.358 314.041 1.00 43.63  ? 175 THR C CG2 1 
ATOM   5721 N N   . TYR C 3 176 ? 172.797 255.738 318.626 1.00 32.32  ? 176 TYR C N   1 
ATOM   5722 C CA  . TYR C 3 176 ? 173.506 255.308 319.820 1.00 29.65  ? 176 TYR C CA  1 
ATOM   5723 C C   . TYR C 3 176 ? 172.715 255.745 321.042 1.00 34.89  ? 176 TYR C C   1 
ATOM   5724 O O   . TYR C 3 176 ? 171.856 256.625 320.967 1.00 51.00  ? 176 TYR C O   1 
ATOM   5725 C CB  . TYR C 3 176 ? 174.924 255.884 319.882 1.00 37.92  ? 176 TYR C CB  1 
ATOM   5726 C CG  . TYR C 3 176 ? 175.919 255.201 318.973 1.00 38.29  ? 176 TYR C CG  1 
ATOM   5727 C CD1 . TYR C 3 176 ? 176.087 255.610 317.659 1.00 40.49  ? 176 TYR C CD1 1 
ATOM   5728 C CD2 . TYR C 3 176 ? 176.701 254.154 319.434 1.00 39.84  ? 176 TYR C CD2 1 
ATOM   5729 C CE1 . TYR C 3 176 ? 176.999 254.992 316.830 1.00 38.49  ? 176 TYR C CE1 1 
ATOM   5730 C CE2 . TYR C 3 176 ? 177.615 253.532 318.612 1.00 44.33  ? 176 TYR C CE2 1 
ATOM   5731 C CZ  . TYR C 3 176 ? 177.760 253.954 317.313 1.00 45.50  ? 176 TYR C CZ  1 
ATOM   5732 O OH  . TYR C 3 176 ? 178.672 253.331 316.496 1.00 50.44  ? 176 TYR C OH  1 
ATOM   5733 N N   . ARG C 3 177 ? 173.012 255.117 322.173 1.00 30.46  ? 177 ARG C N   1 
ATOM   5734 C CA  . ARG C 3 177 ? 172.385 255.447 323.444 1.00 31.91  ? 177 ARG C CA  1 
ATOM   5735 C C   . ARG C 3 177 ? 173.453 255.856 324.445 1.00 41.02  ? 177 ARG C C   1 
ATOM   5736 O O   . ARG C 3 177 ? 174.537 255.268 324.483 1.00 51.19  ? 177 ARG C O   1 
ATOM   5737 C CB  . ARG C 3 177 ? 171.588 254.265 324.002 1.00 39.84  ? 177 ARG C CB  1 
ATOM   5738 C CG  . ARG C 3 177 ? 170.216 254.084 323.387 1.00 44.93  ? 177 ARG C CG  1 
ATOM   5739 C CD  . ARG C 3 177 ? 169.334 253.214 324.265 1.00 40.27  ? 177 ARG C CD  1 
ATOM   5740 N NE  . ARG C 3 177 ? 167.973 253.121 323.749 1.00 42.52  ? 177 ARG C NE  1 
ATOM   5741 C CZ  . ARG C 3 177 ? 167.482 252.090 323.074 1.00 46.60  ? 177 ARG C CZ  1 
ATOM   5742 N NH1 . ARG C 3 177 ? 168.204 251.009 322.832 1.00 49.22  ? 177 ARG C NH1 1 
ATOM   5743 N NH2 . ARG C 3 177 ? 166.230 252.144 322.632 1.00 43.20  ? 177 ARG C NH2 1 
ATOM   5744 N N   . LEU C 3 178 ? 173.146 256.867 325.250 1.00 41.42  ? 178 LEU C N   1 
ATOM   5745 C CA  . LEU C 3 178 ? 174.059 257.275 326.305 1.00 47.19  ? 178 LEU C CA  1 
ATOM   5746 C C   . LEU C 3 178 ? 174.114 256.217 327.399 1.00 48.96  ? 178 LEU C C   1 
ATOM   5747 O O   . LEU C 3 178 ? 173.126 255.538 327.691 1.00 43.27  ? 178 LEU C O   1 
ATOM   5748 C CB  . LEU C 3 178 ? 173.632 258.614 326.904 1.00 44.26  ? 178 LEU C CB  1 
ATOM   5749 C CG  . LEU C 3 178 ? 173.785 259.863 326.037 1.00 44.34  ? 178 LEU C CG  1 
ATOM   5750 C CD1 . LEU C 3 178 ? 173.442 261.098 326.846 1.00 45.57  ? 178 LEU C CD1 1 
ATOM   5751 C CD2 . LEU C 3 178 ? 175.186 259.970 325.476 1.00 39.39  ? 178 LEU C CD2 1 
ATOM   5752 N N   . THR C 3 179 ? 175.288 256.087 328.013 1.00 44.69  ? 179 THR C N   1 
ATOM   5753 C CA  . THR C 3 179 ? 175.502 255.147 329.102 1.00 43.74  ? 179 THR C CA  1 
ATOM   5754 C C   . THR C 3 179 ? 175.132 255.735 330.457 1.00 46.85  ? 179 THR C C   1 
ATOM   5755 O O   . THR C 3 179 ? 175.611 255.249 331.487 1.00 50.64  ? 179 THR C O   1 
ATOM   5756 C CB  . THR C 3 179 ? 176.958 254.681 329.114 1.00 52.74  ? 179 THR C CB  1 
ATOM   5757 O OG1 . THR C 3 179 ? 177.824 255.811 329.259 1.00 48.84  ? 179 THR C OG1 1 
ATOM   5758 C CG2 . THR C 3 179 ? 177.289 253.952 327.826 1.00 46.66  ? 179 THR C CG2 1 
ATOM   5759 N N   . ILE C 3 180 ? 174.296 256.768 330.475 1.00 55.18  ? 180 ILE C N   1 
ATOM   5760 C CA  . ILE C 3 180 ? 173.798 257.381 331.698 1.00 53.97  ? 180 ILE C CA  1 
ATOM   5761 C C   . ILE C 3 180 ? 172.287 257.240 331.701 1.00 56.44  ? 180 ILE C C   1 
ATOM   5762 O O   . ILE C 3 180 ? 171.646 257.362 330.652 1.00 64.00  ? 180 ILE C O   1 
ATOM   5763 C CB  . ILE C 3 180 ? 174.205 258.865 331.800 1.00 55.68  ? 180 ILE C CB  1 
ATOM   5764 C CG1 . ILE C 3 180 ? 173.460 259.700 330.754 1.00 50.16  ? 180 ILE C CG1 1 
ATOM   5765 C CG2 . ILE C 3 180 ? 175.700 259.013 331.612 1.00 57.81  ? 180 ILE C CG2 1 
ATOM   5766 C CD1 . ILE C 3 180 ? 173.890 261.143 330.705 1.00 52.91  ? 180 ILE C CD1 1 
ATOM   5767 N N   . ASP C 3 181 ? 171.713 256.977 332.873 1.00 64.51  ? 181 ASP C N   1 
ATOM   5768 C CA  . ASP C 3 181 ? 170.264 256.873 332.948 1.00 67.44  ? 181 ASP C CA  1 
ATOM   5769 C C   . ASP C 3 181 ? 169.669 258.169 332.419 1.00 71.39  ? 181 ASP C C   1 
ATOM   5770 O O   . ASP C 3 181 ? 169.777 259.219 333.060 1.00 68.48  ? 181 ASP C O   1 
ATOM   5771 C CB  . ASP C 3 181 ? 169.805 256.600 334.379 1.00 67.94  ? 181 ASP C CB  1 
ATOM   5772 C CG  . ASP C 3 181 ? 168.380 256.096 334.445 1.00 71.25  ? 181 ASP C CG  1 
ATOM   5773 O OD1 . ASP C 3 181 ? 167.554 256.532 333.617 1.00 69.35  ? 181 ASP C OD1 1 
ATOM   5774 O OD2 . ASP C 3 181 ? 168.088 255.256 335.322 1.00 73.19  ? 181 ASP C OD2 1 
ATOM   5775 N N   . ASP C 3 182 ? 169.039 258.102 331.251 1.00 69.97  ? 182 ASP C N   1 
ATOM   5776 C CA  . ASP C 3 182 ? 168.620 259.283 330.515 1.00 66.75  ? 182 ASP C CA  1 
ATOM   5777 C C   . ASP C 3 182 ? 167.179 259.118 330.062 1.00 65.67  ? 182 ASP C C   1 
ATOM   5778 O O   . ASP C 3 182 ? 166.757 258.018 329.693 1.00 69.35  ? 182 ASP C O   1 
ATOM   5779 C CB  . ASP C 3 182 ? 169.526 259.519 329.308 1.00 67.23  ? 182 ASP C CB  1 
ATOM   5780 C CG  . ASP C 3 182 ? 169.293 260.863 328.658 1.00 70.91  ? 182 ASP C CG  1 
ATOM   5781 O OD1 . ASP C 3 182 ? 168.406 261.609 329.121 1.00 66.51  ? 182 ASP C OD1 1 
ATOM   5782 O OD2 . ASP C 3 182 ? 170.004 261.172 327.682 1.00 74.49  ? 182 ASP C OD2 1 
ATOM   5783 N N   . SER C 3 183 ? 166.429 260.219 330.092 1.00 60.89  ? 183 SER C N   1 
ATOM   5784 C CA  . SER C 3 183 ? 165.016 260.155 329.738 1.00 61.53  ? 183 SER C CA  1 
ATOM   5785 C C   . SER C 3 183 ? 164.827 260.007 328.234 1.00 59.24  ? 183 SER C C   1 
ATOM   5786 O O   . SER C 3 183 ? 163.987 259.221 327.784 1.00 57.96  ? 183 SER C O   1 
ATOM   5787 C CB  . SER C 3 183 ? 164.300 261.402 330.250 1.00 62.99  ? 183 SER C CB  1 
ATOM   5788 O OG  . SER C 3 183 ? 164.555 261.596 331.629 1.00 57.22  ? 183 SER C OG  1 
ATOM   5789 N N   . PHE C 3 184 ? 165.594 260.756 327.441 1.00 52.34  ? 184 PHE C N   1 
ATOM   5790 C CA  . PHE C 3 184 ? 165.410 260.717 325.994 1.00 52.00  ? 184 PHE C CA  1 
ATOM   5791 C C   . PHE C 3 184 ? 165.866 259.385 325.415 1.00 52.99  ? 184 PHE C C   1 
ATOM   5792 O O   . PHE C 3 184 ? 165.141 258.754 324.639 1.00 57.77  ? 184 PHE C O   1 
ATOM   5793 C CB  . PHE C 3 184 ? 166.165 261.875 325.343 1.00 47.50  ? 184 PHE C CB  1 
ATOM   5794 C CG  . PHE C 3 184 ? 166.034 261.920 323.851 1.00 42.60  ? 184 PHE C CG  1 
ATOM   5795 C CD1 . PHE C 3 184 ? 164.922 262.484 323.256 1.00 50.13  ? 184 PHE C CD1 1 
ATOM   5796 C CD2 . PHE C 3 184 ? 167.029 261.407 323.042 1.00 44.08  ? 184 PHE C CD2 1 
ATOM   5797 C CE1 . PHE C 3 184 ? 164.803 262.527 321.883 1.00 46.78  ? 184 PHE C CE1 1 
ATOM   5798 C CE2 . PHE C 3 184 ? 166.915 261.450 321.671 1.00 47.45  ? 184 PHE C CE2 1 
ATOM   5799 C CZ  . PHE C 3 184 ? 165.802 262.011 321.091 1.00 49.93  ? 184 PHE C CZ  1 
ATOM   5800 N N   . THR C 3 185 ? 167.064 258.941 325.779 1.00 54.43  ? 185 THR C N   1 
ATOM   5801 C CA  . THR C 3 185 ? 167.620 257.691 325.262 1.00 52.44  ? 185 THR C CA  1 
ATOM   5802 C C   . THR C 3 185 ? 167.376 256.544 326.241 1.00 54.66  ? 185 THR C C   1 
ATOM   5803 O O   . THR C 3 185 ? 168.301 255.884 326.711 1.00 58.39  ? 185 THR C O   1 
ATOM   5804 C CB  . THR C 3 185 ? 169.110 257.854 324.977 1.00 56.27  ? 185 THR C CB  1 
ATOM   5805 O OG1 . THR C 3 185 ? 169.782 258.280 326.168 1.00 59.96  ? 185 THR C OG1 1 
ATOM   5806 C CG2 . THR C 3 185 ? 169.337 258.875 323.880 1.00 53.74  ? 185 THR C CG2 1 
ATOM   5807 N N   . GLU C 3 186 ? 166.105 256.307 326.549 1.00 55.51  ? 186 GLU C N   1 
ATOM   5808 C CA  . GLU C 3 186 ? 165.757 255.146 327.350 1.00 55.22  ? 186 GLU C CA  1 
ATOM   5809 C C   . GLU C 3 186 ? 165.929 253.873 326.528 1.00 53.30  ? 186 GLU C C   1 
ATOM   5810 O O   . GLU C 3 186 ? 165.900 253.887 325.295 1.00 52.64  ? 186 GLU C O   1 
ATOM   5811 C CB  . GLU C 3 186 ? 164.324 255.249 327.868 1.00 56.25  ? 186 GLU C CB  1 
ATOM   5812 C CG  . GLU C 3 186 ? 164.168 256.142 329.086 1.00 59.70  ? 186 GLU C CG  1 
ATOM   5813 C CD  . GLU C 3 186 ? 162.781 256.062 329.694 1.00 61.55  ? 186 GLU C CD  1 
ATOM   5814 O OE1 . GLU C 3 186 ? 162.011 255.158 329.308 1.00 62.99  ? 186 GLU C OE1 1 
ATOM   5815 O OE2 . GLU C 3 186 ? 162.459 256.903 330.559 1.00 53.83  ? 186 GLU C OE2 1 
ATOM   5816 N N   . GLY C 3 187 ? 166.118 252.762 327.230 1.00 50.15  ? 187 GLY C N   1 
ATOM   5817 C CA  . GLY C 3 187 ? 166.332 251.490 326.570 1.00 56.39  ? 187 GLY C CA  1 
ATOM   5818 C C   . GLY C 3 187 ? 165.069 250.665 326.454 1.00 59.84  ? 187 GLY C C   1 
ATOM   5819 O O   . GLY C 3 187 ? 164.868 249.956 325.464 1.00 61.41  ? 187 GLY C O   1 
ATOM   5820 N N   . GLY C 3 188 ? 164.209 250.750 327.462 1.00 52.93  ? 188 GLY C N   1 
ATOM   5821 C CA  . GLY C 3 188 ? 162.999 249.969 327.523 1.00 50.61  ? 188 GLY C CA  1 
ATOM   5822 C C   . GLY C 3 188 ? 162.923 249.232 328.835 1.00 53.62  ? 188 GLY C C   1 
ATOM   5823 O O   . GLY C 3 188 ? 163.579 249.599 329.816 1.00 49.82  ? 188 GLY C O   1 
ATOM   5824 N N   . TYR C 3 189 ? 162.113 248.179 328.855 1.00 55.86  ? 189 TYR C N   1 
ATOM   5825 C CA  . TYR C 3 189 ? 161.904 247.385 330.053 1.00 51.16  ? 189 TYR C CA  1 
ATOM   5826 C C   . TYR C 3 189 ? 161.960 245.908 329.703 1.00 50.04  ? 189 TYR C C   1 
ATOM   5827 O O   . TYR C 3 189 ? 161.632 245.510 328.584 1.00 57.48  ? 189 TYR C O   1 
ATOM   5828 C CB  . TYR C 3 189 ? 160.560 247.706 330.702 1.00 47.50  ? 189 TYR C CB  1 
ATOM   5829 C CG  . TYR C 3 189 ? 160.291 249.183 330.845 1.00 52.33  ? 189 TYR C CG  1 
ATOM   5830 C CD1 . TYR C 3 189 ? 160.720 249.882 331.961 1.00 50.92  ? 189 TYR C CD1 1 
ATOM   5831 C CD2 . TYR C 3 189 ? 159.606 249.878 329.862 1.00 56.72  ? 189 TYR C CD2 1 
ATOM   5832 C CE1 . TYR C 3 189 ? 160.476 251.232 332.094 1.00 56.41  ? 189 TYR C CE1 1 
ATOM   5833 C CE2 . TYR C 3 189 ? 159.358 251.228 329.985 1.00 60.14  ? 189 TYR C CE2 1 
ATOM   5834 C CZ  . TYR C 3 189 ? 159.794 251.900 331.103 1.00 60.59  ? 189 TYR C CZ  1 
ATOM   5835 O OH  . TYR C 3 189 ? 159.546 253.247 331.229 1.00 60.25  ? 189 TYR C OH  1 
ATOM   5836 N N   . ILE C 3 190 ? 162.376 245.098 330.672 1.00 50.53  ? 190 ILE C N   1 
ATOM   5837 C CA  . ILE C 3 190 ? 162.397 243.650 330.543 1.00 51.54  ? 190 ILE C CA  1 
ATOM   5838 C C   . ILE C 3 190 ? 161.790 243.062 331.805 1.00 54.13  ? 190 ILE C C   1 
ATOM   5839 O O   . ILE C 3 190 ? 162.061 243.534 332.914 1.00 60.03  ? 190 ILE C O   1 
ATOM   5840 C CB  . ILE C 3 190 ? 163.823 243.110 330.317 1.00 53.56  ? 190 ILE C CB  1 
ATOM   5841 C CG1 . ILE C 3 190 ? 164.333 243.549 328.945 1.00 53.31  ? 190 ILE C CG1 1 
ATOM   5842 C CG2 . ILE C 3 190 ? 163.842 241.590 330.449 1.00 56.85  ? 190 ILE C CG2 1 
ATOM   5843 C CD1 . ILE C 3 190 ? 165.765 243.164 328.670 1.00 55.21  ? 190 ILE C CD1 1 
ATOM   5844 N N   . SER C 3 191 ? 160.949 242.048 331.637 1.00 52.11  ? 191 SER C N   1 
ATOM   5845 C CA  . SER C 3 191 ? 160.254 241.443 332.761 1.00 53.81  ? 191 SER C CA  1 
ATOM   5846 C C   . SER C 3 191 ? 160.098 239.951 332.522 1.00 60.30  ? 191 SER C C   1 
ATOM   5847 O O   . SER C 3 191 ? 160.123 239.482 331.383 1.00 64.28  ? 191 SER C O   1 
ATOM   5848 C CB  . SER C 3 191 ? 158.882 242.088 332.978 1.00 53.93  ? 191 SER C CB  1 
ATOM   5849 O OG  . SER C 3 191 ? 158.130 242.111 331.779 1.00 58.38  ? 191 SER C OG  1 
ATOM   5850 N N   . VAL C 3 192 ? 159.960 239.205 333.613 1.00 59.22  ? 192 VAL C N   1 
ATOM   5851 C CA  . VAL C 3 192 ? 159.703 237.772 333.558 1.00 54.08  ? 192 VAL C CA  1 
ATOM   5852 C C   . VAL C 3 192 ? 158.473 237.473 334.401 1.00 57.60  ? 192 VAL C C   1 
ATOM   5853 O O   . VAL C 3 192 ? 158.396 237.886 335.570 1.00 60.28  ? 192 VAL C O   1 
ATOM   5854 C CB  . VAL C 3 192 ? 160.916 236.951 334.032 1.00 53.17  ? 192 VAL C CB  1 
ATOM   5855 C CG1 . VAL C 3 192 ? 160.547 235.483 334.157 1.00 51.77  ? 192 VAL C CG1 1 
ATOM   5856 C CG2 . VAL C 3 192 ? 162.085 237.133 333.066 1.00 55.44  ? 192 VAL C CG2 1 
ATOM   5857 N N   . PHE C 3 193 ? 157.532 236.737 333.798 1.00 60.31  ? 193 PHE C N   1 
ATOM   5858 C CA  . PHE C 3 193 ? 156.244 236.376 334.374 1.00 58.14  ? 193 PHE C CA  1 
ATOM   5859 C C   . PHE C 3 193 ? 156.078 234.865 334.321 1.00 63.07  ? 193 PHE C C   1 
ATOM   5860 O O   . PHE C 3 193 ? 156.771 234.173 333.573 1.00 65.89  ? 193 PHE C O   1 
ATOM   5861 C CB  . PHE C 3 193 ? 155.061 236.991 333.607 1.00 52.68  ? 193 PHE C CB  1 
ATOM   5862 C CG  . PHE C 3 193 ? 155.007 238.481 333.639 1.00 58.20  ? 193 PHE C CG  1 
ATOM   5863 C CD1 . PHE C 3 193 ? 155.729 239.236 332.735 1.00 63.80  ? 193 PHE C CD1 1 
ATOM   5864 C CD2 . PHE C 3 193 ? 154.202 239.129 334.555 1.00 60.87  ? 193 PHE C CD2 1 
ATOM   5865 C CE1 . PHE C 3 193 ? 155.668 240.609 332.761 1.00 58.62  ? 193 PHE C CE1 1 
ATOM   5866 C CE2 . PHE C 3 193 ? 154.139 240.501 334.587 1.00 64.53  ? 193 PHE C CE2 1 
ATOM   5867 C CZ  . PHE C 3 193 ? 154.870 241.243 333.688 1.00 61.45  ? 193 PHE C CZ  1 
ATOM   5868 N N   . TYR C 3 194 ? 155.118 234.363 335.094 1.00 58.20  ? 194 TYR C N   1 
ATOM   5869 C CA  . TYR C 3 194 ? 154.653 232.987 334.963 1.00 56.41  ? 194 TYR C CA  1 
ATOM   5870 C C   . TYR C 3 194 ? 153.608 232.933 333.859 1.00 64.53  ? 194 TYR C C   1 
ATOM   5871 O O   . TYR C 3 194 ? 152.543 233.543 333.981 1.00 71.68  ? 194 TYR C O   1 
ATOM   5872 C CB  . TYR C 3 194 ? 154.033 232.486 336.263 1.00 60.47  ? 194 TYR C CB  1 
ATOM   5873 C CG  . TYR C 3 194 ? 154.960 232.402 337.443 1.00 66.39  ? 194 TYR C CG  1 
ATOM   5874 C CD1 . TYR C 3 194 ? 155.926 231.414 337.518 1.00 63.66  ? 194 TYR C CD1 1 
ATOM   5875 C CD2 . TYR C 3 194 ? 154.845 233.291 338.500 1.00 65.92  ? 194 TYR C CD2 1 
ATOM   5876 C CE1 . TYR C 3 194 ? 156.766 231.324 338.601 1.00 60.57  ? 194 TYR C CE1 1 
ATOM   5877 C CE2 . TYR C 3 194 ? 155.682 233.208 339.591 1.00 67.38  ? 194 TYR C CE2 1 
ATOM   5878 C CZ  . TYR C 3 194 ? 156.640 232.223 339.637 1.00 64.55  ? 194 TYR C CZ  1 
ATOM   5879 O OH  . TYR C 3 194 ? 157.476 232.140 340.725 1.00 59.33  ? 194 TYR C OH  1 
ATOM   5880 N N   . GLN C 3 195 ? 153.897 232.207 332.779 1.00 60.91  ? 195 GLN C N   1 
ATOM   5881 C CA  . GLN C 3 195 ? 152.826 231.843 331.859 1.00 57.28  ? 195 GLN C CA  1 
ATOM   5882 C C   . GLN C 3 195 ? 152.009 230.691 332.426 1.00 59.39  ? 195 GLN C C   1 
ATOM   5883 O O   . GLN C 3 195 ? 150.774 230.745 332.465 1.00 60.73  ? 195 GLN C O   1 
ATOM   5884 C CB  . GLN C 3 195 ? 153.388 231.473 330.490 1.00 54.03  ? 195 GLN C CB  1 
ATOM   5885 C CG  . GLN C 3 195 ? 152.313 230.973 329.534 1.00 59.61  ? 195 GLN C CG  1 
ATOM   5886 C CD  . GLN C 3 195 ? 152.368 231.624 328.166 1.00 59.72  ? 195 GLN C CD  1 
ATOM   5887 O OE1 . GLN C 3 195 ? 153.090 232.595 327.953 1.00 65.44  ? 195 GLN C OE1 1 
ATOM   5888 N NE2 . GLN C 3 195 ? 151.589 231.094 327.231 1.00 58.57  ? 195 GLN C NE2 1 
ATOM   5889 N N   . THR C 3 196 ? 152.688 229.643 332.877 1.00 58.47  ? 196 THR C N   1 
ATOM   5890 C CA  . THR C 3 196 ? 152.062 228.497 333.516 1.00 57.08  ? 196 THR C CA  1 
ATOM   5891 C C   . THR C 3 196 ? 152.897 228.142 334.735 1.00 61.34  ? 196 THR C C   1 
ATOM   5892 O O   . THR C 3 196 ? 154.114 227.971 334.623 1.00 66.91  ? 196 THR C O   1 
ATOM   5893 C CB  . THR C 3 196 ? 151.967 227.318 332.544 1.00 59.31  ? 196 THR C CB  1 
ATOM   5894 O OG1 . THR C 3 196 ? 151.338 227.753 331.332 1.00 60.52  ? 196 THR C OG1 1 
ATOM   5895 C CG2 . THR C 3 196 ? 151.155 226.181 333.130 1.00 64.33  ? 196 THR C CG2 1 
ATOM   5896 N N   . ARG C 3 197 ? 152.250 228.028 335.890 1.00 65.92  ? 197 ARG C N   1 
ATOM   5897 C CA  . ARG C 3 197 ? 152.986 227.938 337.141 1.00 69.60  ? 197 ARG C CA  1 
ATOM   5898 C C   . ARG C 3 197 ? 153.897 226.715 337.144 1.00 74.98  ? 197 ARG C C   1 
ATOM   5899 O O   . ARG C 3 197 ? 153.656 225.719 336.457 1.00 75.25  ? 197 ARG C O   1 
ATOM   5900 C CB  . ARG C 3 197 ? 152.028 227.868 338.325 1.00 69.10  ? 197 ARG C CB  1 
ATOM   5901 C CG  . ARG C 3 197 ? 151.306 226.538 338.441 1.00 73.23  ? 197 ARG C CG  1 
ATOM   5902 C CD  . ARG C 3 197 ? 150.316 226.537 339.581 1.00 77.18  ? 197 ARG C CD  1 
ATOM   5903 N NE  . ARG C 3 197 ? 149.602 225.270 339.667 1.00 76.05  ? 197 ARG C NE  1 
ATOM   5904 C CZ  . ARG C 3 197 ? 150.069 224.184 340.270 1.00 70.01  ? 197 ARG C CZ  1 
ATOM   5905 N NH1 . ARG C 3 197 ? 151.242 224.179 340.877 1.00 61.34  ? 197 ARG C NH1 1 
ATOM   5906 N NH2 . ARG C 3 197 ? 149.340 223.074 340.257 1.00 75.48  ? 197 ARG C NH2 1 
ATOM   5907 N N   . ILE C 3 198 ? 154.964 226.803 337.937 1.00 73.51  ? 198 ILE C N   1 
ATOM   5908 C CA  . ILE C 3 198 ? 155.855 225.666 338.121 1.00 69.68  ? 198 ILE C CA  1 
ATOM   5909 C C   . ILE C 3 198 ? 155.129 224.595 338.920 1.00 70.97  ? 198 ILE C C   1 
ATOM   5910 O O   . ILE C 3 198 ? 154.600 224.862 340.005 1.00 70.29  ? 198 ILE C O   1 
ATOM   5911 C CB  . ILE C 3 198 ? 157.149 226.103 338.823 1.00 70.68  ? 198 ILE C CB  1 
ATOM   5912 C CG1 . ILE C 3 198 ? 157.844 227.215 338.034 1.00 75.24  ? 198 ILE C CG1 1 
ATOM   5913 C CG2 . ILE C 3 198 ? 158.085 224.911 338.987 1.00 72.74  ? 198 ILE C CG2 1 
ATOM   5914 C CD1 . ILE C 3 198 ? 158.538 226.733 336.797 1.00 76.15  ? 198 ILE C CD1 1 
ATOM   5915 N N   . VAL C 3 199 ? 155.099 223.378 338.387 1.00 74.15  ? 199 VAL C N   1 
ATOM   5916 C CA  . VAL C 3 199 ? 154.415 222.255 339.017 1.00 72.46  ? 199 VAL C CA  1 
ATOM   5917 C C   . VAL C 3 199 ? 155.460 221.208 339.365 1.00 70.59  ? 199 VAL C C   1 
ATOM   5918 O O   . VAL C 3 199 ? 156.161 220.700 338.482 1.00 69.75  ? 199 VAL C O   1 
ATOM   5919 C CB  . VAL C 3 199 ? 153.323 221.662 338.113 1.00 71.11  ? 199 VAL C CB  1 
ATOM   5920 C CG1 . VAL C 3 199 ? 152.282 222.718 337.773 1.00 71.56  ? 199 VAL C CG1 1 
ATOM   5921 C CG2 . VAL C 3 199 ? 153.926 221.082 336.849 1.00 74.28  ? 199 VAL C CG2 1 
ATOM   5922 N N   . VAL C 3 200 ? 155.568 220.899 340.647 1.00 70.12  ? 200 VAL C N   1 
ATOM   5923 C CA  . VAL C 3 200 ? 156.566 219.975 341.178 1.00 70.20  ? 200 VAL C CA  1 
ATOM   5924 C C   . VAL C 3 200 ? 155.831 218.780 341.770 1.00 72.87  ? 200 VAL C C   1 
ATOM   5925 O O   . VAL C 3 200 ? 154.834 218.971 342.475 1.00 74.84  ? 200 VAL C O   1 
ATOM   5926 C CB  . VAL C 3 200 ? 157.452 220.645 342.246 1.00 69.25  ? 200 VAL C CB  1 
ATOM   5927 C CG1 . VAL C 3 200 ? 158.487 221.538 341.594 1.00 72.15  ? 200 VAL C CG1 1 
ATOM   5928 C CG2 . VAL C 3 200 ? 156.600 221.459 343.203 1.00 70.43  ? 200 VAL C CG2 1 
ATOM   5929 N N   . PRO C 3 201 ? 156.275 217.551 341.519 1.00 71.22  ? 201 PRO C N   1 
ATOM   5930 C CA  . PRO C 3 201 ? 155.641 216.398 342.162 1.00 71.97  ? 201 PRO C CA  1 
ATOM   5931 C C   . PRO C 3 201 ? 155.918 216.395 343.656 1.00 75.94  ? 201 PRO C C   1 
ATOM   5932 O O   . PRO C 3 201 ? 156.585 217.276 344.201 1.00 78.35  ? 201 PRO C O   1 
ATOM   5933 C CB  . PRO C 3 201 ? 156.282 215.199 341.462 1.00 70.65  ? 201 PRO C CB  1 
ATOM   5934 C CG  . PRO C 3 201 ? 157.589 215.691 341.020 1.00 71.57  ? 201 PRO C CG  1 
ATOM   5935 C CD  . PRO C 3 201 ? 157.410 217.141 340.677 1.00 71.74  ? 201 PRO C CD  1 
ATOM   5936 N N   . LEU C 3 202 ? 155.380 215.382 344.326 1.00 70.32  ? 202 LEU C N   1 
ATOM   5937 C CA  . LEU C 3 202 ? 155.582 215.270 345.760 1.00 71.22  ? 202 LEU C CA  1 
ATOM   5938 C C   . LEU C 3 202 ? 157.000 214.788 346.059 1.00 71.63  ? 202 LEU C C   1 
ATOM   5939 O O   . LEU C 3 202 ? 157.702 214.243 345.202 1.00 72.52  ? 202 LEU C O   1 
ATOM   5940 C CB  . LEU C 3 202 ? 154.553 214.325 346.377 1.00 72.24  ? 202 LEU C CB  1 
ATOM   5941 C CG  . LEU C 3 202 ? 153.226 214.942 346.833 1.00 75.41  ? 202 LEU C CG  1 
ATOM   5942 C CD1 . LEU C 3 202 ? 152.410 213.907 347.590 1.00 70.78  ? 202 LEU C CD1 1 
ATOM   5943 C CD2 . LEU C 3 202 ? 153.452 216.179 347.691 1.00 73.56  ? 202 LEU C CD2 1 
ATOM   5944 N N   . SER C 3 203 ? 157.418 214.997 347.305 1.00 76.60  ? 203 SER C N   1 
ATOM   5945 C CA  . SER C 3 203 ? 158.773 214.669 347.741 1.00 77.27  ? 203 SER C CA  1 
ATOM   5946 C C   . SER C 3 203 ? 159.809 215.332 346.837 1.00 76.44  ? 203 SER C C   1 
ATOM   5947 O O   . SER C 3 203 ? 160.832 214.744 346.485 1.00 78.85  ? 203 SER C O   1 
ATOM   5948 C CB  . SER C 3 203 ? 158.983 213.156 347.792 1.00 73.81  ? 203 SER C CB  1 
ATOM   5949 O OG  . SER C 3 203 ? 160.281 212.842 348.260 1.00 73.55  ? 203 SER C OG  1 
ATOM   5950 N N   . THR C 3 204 ? 159.535 216.581 346.462 1.00 72.05  ? 204 THR C N   1 
ATOM   5951 C CA  . THR C 3 204 ? 160.392 217.366 345.594 1.00 75.83  ? 204 THR C CA  1 
ATOM   5952 C C   . THR C 3 204 ? 160.488 218.765 346.187 1.00 77.64  ? 204 THR C C   1 
ATOM   5953 O O   . THR C 3 204 ? 159.506 219.253 346.766 1.00 75.64  ? 204 THR C O   1 
ATOM   5954 C CB  . THR C 3 204 ? 159.821 217.427 344.169 1.00 77.16  ? 204 THR C CB  1 
ATOM   5955 O OG1 . THR C 3 204 ? 159.617 216.095 343.682 1.00 78.24  ? 204 THR C OG1 1 
ATOM   5956 C CG2 . THR C 3 204 ? 160.751 218.165 343.221 1.00 73.59  ? 204 THR C CG2 1 
ATOM   5957 N N   . PRO C 3 205 ? 161.635 219.436 346.072 1.00 80.54  ? 205 PRO C N   1 
ATOM   5958 C CA  . PRO C 3 205 ? 161.721 220.803 346.594 1.00 78.76  ? 205 PRO C CA  1 
ATOM   5959 C C   . PRO C 3 205 ? 160.697 221.704 345.925 1.00 78.89  ? 205 PRO C C   1 
ATOM   5960 O O   . PRO C 3 205 ? 160.388 221.553 344.741 1.00 80.71  ? 205 PRO C O   1 
ATOM   5961 C CB  . PRO C 3 205 ? 163.157 221.225 346.262 1.00 78.15  ? 205 PRO C CB  1 
ATOM   5962 C CG  . PRO C 3 205 ? 163.607 220.282 345.203 1.00 77.49  ? 205 PRO C CG  1 
ATOM   5963 C CD  . PRO C 3 205 ? 162.925 218.994 345.515 1.00 78.91  ? 205 PRO C CD  1 
ATOM   5964 N N   . ARG C 3 206 ? 160.164 222.645 346.701 1.00 76.81  ? 206 ARG C N   1 
ATOM   5965 C CA  . ARG C 3 206 ? 159.081 223.513 346.258 1.00 78.31  ? 206 ARG C CA  1 
ATOM   5966 C C   . ARG C 3 206 ? 159.529 224.968 346.130 1.00 79.59  ? 206 ARG C C   1 
ATOM   5967 O O   . ARG C 3 206 ? 158.716 225.886 346.248 1.00 82.61  ? 206 ARG C O   1 
ATOM   5968 C CB  . ARG C 3 206 ? 157.899 223.397 347.218 1.00 76.56  ? 206 ARG C CB  1 
ATOM   5969 C CG  . ARG C 3 206 ? 156.581 223.889 346.653 1.00 78.15  ? 206 ARG C CG  1 
ATOM   5970 C CD  . ARG C 3 206 ? 155.416 223.508 347.552 1.00 80.51  ? 206 ARG C CD  1 
ATOM   5971 N NE  . ARG C 3 206 ? 155.170 222.071 347.546 1.00 81.67  ? 206 ARG C NE  1 
ATOM   5972 C CZ  . ARG C 3 206 ? 154.381 221.445 346.683 1.00 81.24  ? 206 ARG C CZ  1 
ATOM   5973 N NH1 . ARG C 3 206 ? 153.737 222.100 345.731 1.00 77.99  ? 206 ARG C NH1 1 
ATOM   5974 N NH2 . ARG C 3 206 ? 154.236 220.126 346.776 1.00 77.72  ? 206 ARG C NH2 1 
ATOM   5975 N N   . GLU C 3 207 ? 160.822 225.193 345.891 1.00 71.16  ? 207 GLU C N   1 
ATOM   5976 C CA  . GLU C 3 207 ? 161.352 226.547 345.736 1.00 73.20  ? 207 GLU C CA  1 
ATOM   5977 C C   . GLU C 3 207 ? 162.523 226.467 344.761 1.00 74.60  ? 207 GLU C C   1 
ATOM   5978 O O   . GLU C 3 207 ? 163.627 226.078 345.148 1.00 78.69  ? 207 GLU C O   1 
ATOM   5979 C CB  . GLU C 3 207 ? 161.786 227.128 347.076 1.00 74.77  ? 207 GLU C CB  1 
ATOM   5980 C CG  . GLU C 3 207 ? 160.666 227.292 348.093 1.00 79.01  ? 207 GLU C CG  1 
ATOM   5981 C CD  . GLU C 3 207 ? 159.629 228.315 347.669 1.00 85.20  ? 207 GLU C CD  1 
ATOM   5982 O OE1 . GLU C 3 207 ? 159.853 229.005 346.652 1.00 91.15  ? 207 GLU C OE1 1 
ATOM   5983 O OE2 . GLU C 3 207 ? 158.591 228.433 348.353 1.00 78.98  ? 207 GLU C OE2 1 
ATOM   5984 N N   . MET C 3 208 ? 162.277 226.835 343.507 1.00 72.51  ? 208 MET C N   1 
ATOM   5985 C CA  . MET C 3 208 ? 163.304 226.768 342.477 1.00 71.79  ? 208 MET C CA  1 
ATOM   5986 C C   . MET C 3 208 ? 164.195 228.005 342.570 1.00 73.86  ? 208 MET C C   1 
ATOM   5987 O O   . MET C 3 208 ? 164.097 228.807 343.502 1.00 74.99  ? 208 MET C O   1 
ATOM   5988 C CB  . MET C 3 208 ? 162.671 226.651 341.092 1.00 73.57  ? 208 MET C CB  1 
ATOM   5989 C CG  . MET C 3 208 ? 161.453 225.741 340.996 1.00 74.92  ? 208 MET C CG  1 
ATOM   5990 S SD  . MET C 3 208 ? 161.820 223.996 341.238 1.00 89.49  ? 208 MET C SD  1 
ATOM   5991 C CE  . MET C 3 208 ? 161.819 223.885 343.022 1.00 80.32  ? 208 MET C CE  1 
ATOM   5992 N N   . ASP C 3 209 ? 165.080 228.170 341.588 1.00 67.16  ? 209 ASP C N   1 
ATOM   5993 C CA  . ASP C 3 209 ? 165.913 229.361 341.473 1.00 67.42  ? 209 ASP C CA  1 
ATOM   5994 C C   . ASP C 3 209 ? 166.364 229.480 340.026 1.00 64.83  ? 209 ASP C C   1 
ATOM   5995 O O   . ASP C 3 209 ? 166.793 228.487 339.432 1.00 65.82  ? 209 ASP C O   1 
ATOM   5996 C CB  . ASP C 3 209 ? 167.133 229.289 342.400 1.00 70.82  ? 209 ASP C CB  1 
ATOM   5997 C CG  . ASP C 3 209 ? 166.791 229.580 343.847 1.00 72.13  ? 209 ASP C CG  1 
ATOM   5998 O OD1 . ASP C 3 209 ? 165.953 230.470 344.096 1.00 72.32  ? 209 ASP C OD1 1 
ATOM   5999 O OD2 . ASP C 3 209 ? 167.363 228.919 344.738 1.00 67.05  ? 209 ASP C OD2 1 
ATOM   6000 N N   . ILE C 3 210 ? 166.269 230.682 339.464 1.00 60.30  ? 210 ILE C N   1 
ATOM   6001 C CA  . ILE C 3 210 ? 166.717 230.947 338.103 1.00 63.46  ? 210 ILE C CA  1 
ATOM   6002 C C   . ILE C 3 210 ? 167.804 232.011 338.145 1.00 60.83  ? 210 ILE C C   1 
ATOM   6003 O O   . ILE C 3 210 ? 167.688 233.007 338.868 1.00 63.70  ? 210 ILE C O   1 
ATOM   6004 C CB  . ILE C 3 210 ? 165.558 231.381 337.181 1.00 60.18  ? 210 ILE C CB  1 
ATOM   6005 C CG1 . ILE C 3 210 ? 164.982 232.728 337.617 1.00 62.88  ? 210 ILE C CG1 1 
ATOM   6006 C CG2 . ILE C 3 210 ? 164.472 230.325 337.178 1.00 60.09  ? 210 ILE C CG2 1 
ATOM   6007 C CD1 . ILE C 3 210 ? 163.852 233.217 336.741 1.00 65.69  ? 210 ILE C CD1 1 
ATOM   6008 N N   . LEU C 3 211 ? 168.860 231.789 337.372 1.00 47.76  ? 211 LEU C N   1 
ATOM   6009 C CA  . LEU C 3 211 ? 170.007 232.681 337.304 1.00 50.00  ? 211 LEU C CA  1 
ATOM   6010 C C   . LEU C 3 211 ? 170.026 233.374 335.951 1.00 48.79  ? 211 LEU C C   1 
ATOM   6011 O O   . LEU C 3 211 ? 169.885 232.719 334.912 1.00 54.67  ? 211 LEU C O   1 
ATOM   6012 C CB  . LEU C 3 211 ? 171.310 231.912 337.513 1.00 55.46  ? 211 LEU C CB  1 
ATOM   6013 C CG  . LEU C 3 211 ? 171.344 230.977 338.718 1.00 49.99  ? 211 LEU C CG  1 
ATOM   6014 C CD1 . LEU C 3 211 ? 172.719 230.356 338.845 1.00 45.62  ? 211 LEU C CD1 1 
ATOM   6015 C CD2 . LEU C 3 211 ? 170.965 231.718 339.983 1.00 50.10  ? 211 LEU C CD2 1 
ATOM   6016 N N   . GLY C 3 212 ? 170.204 234.692 335.966 1.00 43.62  ? 212 GLY C N   1 
ATOM   6017 C CA  . GLY C 3 212 ? 170.254 235.451 334.737 1.00 46.87  ? 212 GLY C CA  1 
ATOM   6018 C C   . GLY C 3 212 ? 171.650 235.531 334.153 1.00 52.32  ? 212 GLY C C   1 
ATOM   6019 O O   . GLY C 3 212 ? 172.637 235.171 334.784 1.00 62.20  ? 212 GLY C O   1 
ATOM   6020 N N   . PHE C 3 213 ? 171.706 236.010 332.913 1.00 51.48  ? 213 PHE C N   1 
ATOM   6021 C CA  . PHE C 3 213 ? 172.955 236.218 332.194 1.00 48.72  ? 213 PHE C CA  1 
ATOM   6022 C C   . PHE C 3 213 ? 172.693 237.274 331.137 1.00 54.25  ? 213 PHE C C   1 
ATOM   6023 O O   . PHE C 3 213 ? 171.668 237.217 330.458 1.00 64.13  ? 213 PHE C O   1 
ATOM   6024 C CB  . PHE C 3 213 ? 173.446 234.929 331.530 1.00 53.55  ? 213 PHE C CB  1 
ATOM   6025 C CG  . PHE C 3 213 ? 173.839 233.851 332.494 1.00 58.86  ? 213 PHE C CG  1 
ATOM   6026 C CD1 . PHE C 3 213 ? 175.115 233.809 333.021 1.00 57.54  ? 213 PHE C CD1 1 
ATOM   6027 C CD2 . PHE C 3 213 ? 172.938 232.870 332.858 1.00 49.79  ? 213 PHE C CD2 1 
ATOM   6028 C CE1 . PHE C 3 213 ? 175.479 232.817 333.902 1.00 52.57  ? 213 PHE C CE1 1 
ATOM   6029 C CE2 . PHE C 3 213 ? 173.298 231.876 333.738 1.00 49.16  ? 213 PHE C CE2 1 
ATOM   6030 C CZ  . PHE C 3 213 ? 174.570 231.850 334.260 1.00 50.45  ? 213 PHE C CZ  1 
ATOM   6031 N N   . VAL C 3 214 ? 173.608 238.225 330.993 1.00 55.20  ? 214 VAL C N   1 
ATOM   6032 C CA  . VAL C 3 214 ? 173.463 239.309 330.030 1.00 48.20  ? 214 VAL C CA  1 
ATOM   6033 C C   . VAL C 3 214 ? 174.734 239.387 329.205 1.00 45.03  ? 214 VAL C C   1 
ATOM   6034 O O   . VAL C 3 214 ? 175.838 239.388 329.759 1.00 48.13  ? 214 VAL C O   1 
ATOM   6035 C CB  . VAL C 3 214 ? 173.183 240.657 330.719 1.00 46.02  ? 214 VAL C CB  1 
ATOM   6036 C CG1 . VAL C 3 214 ? 174.283 240.992 331.715 1.00 52.22  ? 214 VAL C CG1 1 
ATOM   6037 C CG2 . VAL C 3 214 ? 173.043 241.758 329.688 1.00 50.79  ? 214 VAL C CG2 1 
ATOM   6038 N N   . SER C 3 215 ? 174.586 239.450 327.886 1.00 48.58  ? 215 SER C N   1 
ATOM   6039 C CA  . SER C 3 215 ? 175.748 239.607 327.027 1.00 52.15  ? 215 SER C CA  1 
ATOM   6040 C C   . SER C 3 215 ? 175.366 240.429 325.807 1.00 50.59  ? 215 SER C C   1 
ATOM   6041 O O   . SER C 3 215 ? 174.193 240.710 325.557 1.00 56.99  ? 215 SER C O   1 
ATOM   6042 C CB  . SER C 3 215 ? 176.323 238.254 326.609 1.00 56.19  ? 215 SER C CB  1 
ATOM   6043 O OG  . SER C 3 215 ? 175.424 237.553 325.771 1.00 61.86  ? 215 SER C OG  1 
ATOM   6044 N N   . ALA C 3 216 ? 176.383 240.836 325.062 1.00 44.90  ? 216 ALA C N   1 
ATOM   6045 C CA  . ALA C 3 216 ? 176.177 241.573 323.830 1.00 43.93  ? 216 ALA C CA  1 
ATOM   6046 C C   . ALA C 3 216 ? 176.126 240.610 322.655 1.00 50.58  ? 216 ALA C C   1 
ATOM   6047 O O   . ALA C 3 216 ? 176.742 239.542 322.674 1.00 50.43  ? 216 ALA C O   1 
ATOM   6048 C CB  . ALA C 3 216 ? 177.287 242.600 323.621 1.00 45.46  ? 216 ALA C CB  1 
ATOM   6049 N N   . CYS C 3 217 ? 175.374 240.992 321.630 1.00 54.22  ? 217 CYS C N   1 
ATOM   6050 C CA  . CYS C 3 217 ? 175.304 240.201 320.416 1.00 52.97  ? 217 CYS C CA  1 
ATOM   6051 C C   . CYS C 3 217 ? 176.449 240.600 319.488 1.00 57.42  ? 217 CYS C C   1 
ATOM   6052 O O   . CYS C 3 217 ? 177.237 241.500 319.784 1.00 59.65  ? 217 CYS C O   1 
ATOM   6053 C CB  . CYS C 3 217 ? 173.949 240.373 319.737 1.00 54.62  ? 217 CYS C CB  1 
ATOM   6054 S SG  . CYS C 3 217 ? 173.607 239.115 318.492 1.00 71.71  ? 217 CYS C SG  1 
ATOM   6055 N N   . ASN C 3 218 ? 176.547 239.922 318.346 1.00 57.84  ? 218 ASN C N   1 
ATOM   6056 C CA  . ASN C 3 218 ? 177.673 240.145 317.448 1.00 56.28  ? 218 ASN C CA  1 
ATOM   6057 C C   . ASN C 3 218 ? 177.592 241.472 316.705 1.00 59.83  ? 218 ASN C C   1 
ATOM   6058 O O   . ASN C 3 218 ? 178.547 241.816 316.000 1.00 61.49  ? 218 ASN C O   1 
ATOM   6059 C CB  . ASN C 3 218 ? 177.779 238.994 316.445 1.00 55.24  ? 218 ASN C CB  1 
ATOM   6060 C CG  . ASN C 3 218 ? 176.603 238.936 315.494 1.00 60.07  ? 218 ASN C CG  1 
ATOM   6061 O OD1 . ASN C 3 218 ? 175.507 239.394 315.813 1.00 59.47  ? 218 ASN C OD1 1 
ATOM   6062 N ND2 . ASN C 3 218 ? 176.825 238.365 314.315 1.00 60.26  ? 218 ASN C ND2 1 
ATOM   6063 N N   . ASP C 3 219 ? 176.495 242.216 316.831 1.00 55.85  ? 219 ASP C N   1 
ATOM   6064 C CA  . ASP C 3 219 ? 176.352 243.519 316.194 1.00 57.14  ? 219 ASP C CA  1 
ATOM   6065 C C   . ASP C 3 219 ? 176.596 244.675 317.158 1.00 52.50  ? 219 ASP C C   1 
ATOM   6066 O O   . ASP C 3 219 ? 176.400 245.833 316.782 1.00 52.77  ? 219 ASP C O   1 
ATOM   6067 C CB  . ASP C 3 219 ? 174.962 243.649 315.568 1.00 57.88  ? 219 ASP C CB  1 
ATOM   6068 C CG  . ASP C 3 219 ? 173.846 243.591 316.595 1.00 60.13  ? 219 ASP C CG  1 
ATOM   6069 O OD1 . ASP C 3 219 ? 174.145 243.526 317.805 1.00 61.34  ? 219 ASP C OD1 1 
ATOM   6070 O OD2 . ASP C 3 219 ? 172.665 243.609 316.192 1.00 56.58  ? 219 ASP C OD2 1 
ATOM   6071 N N   . PHE C 3 220 ? 177.023 244.388 318.384 1.00 35.58  ? 220 PHE C N   1 
ATOM   6072 C CA  . PHE C 3 220 ? 177.203 245.423 319.389 1.00 34.36  ? 220 PHE C CA  1 
ATOM   6073 C C   . PHE C 3 220 ? 178.410 246.296 319.059 1.00 41.71  ? 220 PHE C C   1 
ATOM   6074 O O   . PHE C 3 220 ? 179.294 245.916 318.287 1.00 50.62  ? 220 PHE C O   1 
ATOM   6075 C CB  . PHE C 3 220 ? 177.379 244.788 320.765 1.00 36.04  ? 220 PHE C CB  1 
ATOM   6076 C CG  . PHE C 3 220 ? 177.004 245.688 321.902 1.00 35.39  ? 220 PHE C CG  1 
ATOM   6077 C CD1 . PHE C 3 220 ? 175.699 245.749 322.347 1.00 44.07  ? 220 PHE C CD1 1 
ATOM   6078 C CD2 . PHE C 3 220 ? 177.956 246.461 322.534 1.00 37.01  ? 220 PHE C CD2 1 
ATOM   6079 C CE1 . PHE C 3 220 ? 175.351 246.571 323.394 1.00 44.56  ? 220 PHE C CE1 1 
ATOM   6080 C CE2 . PHE C 3 220 ? 177.611 247.285 323.582 1.00 41.83  ? 220 PHE C CE2 1 
ATOM   6081 C CZ  . PHE C 3 220 ? 176.308 247.339 324.012 1.00 42.94  ? 220 PHE C CZ  1 
ATOM   6082 N N   . SER C 3 221 ? 178.437 247.486 319.655 1.00 32.35  ? 221 SER C N   1 
ATOM   6083 C CA  . SER C 3 221 ? 179.561 248.398 319.492 1.00 34.19  ? 221 SER C CA  1 
ATOM   6084 C C   . SER C 3 221 ? 179.411 249.556 320.465 1.00 29.16  ? 221 SER C C   1 
ATOM   6085 O O   . SER C 3 221 ? 178.300 249.893 320.880 1.00 30.75  ? 221 SER C O   1 
ATOM   6086 C CB  . SER C 3 221 ? 179.652 248.926 318.059 1.00 33.53  ? 221 SER C CB  1 
ATOM   6087 O OG  . SER C 3 221 ? 178.503 249.679 317.727 1.00 37.20  ? 221 SER C OG  1 
ATOM   6088 N N   . VAL C 3 222 ? 180.547 250.156 320.822 1.00 37.63  ? 222 VAL C N   1 
ATOM   6089 C CA  . VAL C 3 222 ? 180.603 251.320 321.698 1.00 36.76  ? 222 VAL C CA  1 
ATOM   6090 C C   . VAL C 3 222 ? 181.612 252.302 321.119 1.00 37.65  ? 222 VAL C C   1 
ATOM   6091 O O   . VAL C 3 222 ? 182.415 251.960 320.249 1.00 40.18  ? 222 VAL C O   1 
ATOM   6092 C CB  . VAL C 3 222 ? 180.989 250.950 323.145 1.00 35.48  ? 222 VAL C CB  1 
ATOM   6093 C CG1 . VAL C 3 222 ? 179.948 250.038 323.758 1.00 36.95  ? 222 VAL C CG1 1 
ATOM   6094 C CG2 . VAL C 3 222 ? 182.352 250.289 323.175 1.00 39.20  ? 222 VAL C CG2 1 
ATOM   6095 N N   . ARG C 3 223 ? 181.569 253.537 321.612 1.00 42.18  ? 223 ARG C N   1 
ATOM   6096 C CA  . ARG C 3 223 ? 182.506 254.553 321.155 1.00 38.66  ? 223 ARG C CA  1 
ATOM   6097 C C   . ARG C 3 223 ? 182.606 255.655 322.201 1.00 36.78  ? 223 ARG C C   1 
ATOM   6098 O O   . ARG C 3 223 ? 181.883 255.665 323.199 1.00 31.69  ? 223 ARG C O   1 
ATOM   6099 C CB  . ARG C 3 223 ? 182.089 255.124 319.797 1.00 27.11  ? 223 ARG C CB  1 
ATOM   6100 C CG  . ARG C 3 223 ? 180.797 255.907 319.823 1.00 30.62  ? 223 ARG C CG  1 
ATOM   6101 C CD  . ARG C 3 223 ? 180.513 256.551 318.482 1.00 37.46  ? 223 ARG C CD  1 
ATOM   6102 N NE  . ARG C 3 223 ? 179.436 257.527 318.583 1.00 29.02  ? 223 ARG C NE  1 
ATOM   6103 C CZ  . ARG C 3 223 ? 179.029 258.298 317.585 1.00 26.94  ? 223 ARG C CZ  1 
ATOM   6104 N NH1 . ARG C 3 223 ? 179.572 258.218 316.383 1.00 37.95  ? 223 ARG C NH1 1 
ATOM   6105 N NH2 . ARG C 3 223 ? 178.053 259.173 317.800 1.00 40.87  ? 223 ARG C NH2 1 
ATOM   6106 N N   . LEU C 3 224 ? 183.521 256.592 321.948 1.00 43.61  ? 224 LEU C N   1 
ATOM   6107 C CA  . LEU C 3 224 ? 183.756 257.751 322.808 1.00 39.10  ? 224 LEU C CA  1 
ATOM   6108 C C   . LEU C 3 224 ? 184.160 257.312 324.219 1.00 37.57  ? 224 LEU C C   1 
ATOM   6109 O O   . LEU C 3 224 ? 183.432 257.488 325.196 1.00 39.78  ? 224 LEU C O   1 
ATOM   6110 C CB  . LEU C 3 224 ? 182.523 258.661 322.846 1.00 42.41  ? 224 LEU C CB  1 
ATOM   6111 C CG  . LEU C 3 224 ? 182.698 260.043 323.488 1.00 33.04  ? 224 LEU C CG  1 
ATOM   6112 C CD1 . LEU C 3 224 ? 184.006 260.689 323.075 1.00 33.48  ? 224 LEU C CD1 1 
ATOM   6113 C CD2 . LEU C 3 224 ? 181.544 260.954 323.118 1.00 26.95  ? 224 LEU C CD2 1 
ATOM   6114 N N   . LEU C 3 225 ? 185.351 256.718 324.286 1.00 38.02  ? 225 LEU C N   1 
ATOM   6115 C CA  . LEU C 3 225 ? 185.923 256.268 325.550 1.00 37.42  ? 225 LEU C CA  1 
ATOM   6116 C C   . LEU C 3 225 ? 185.794 257.344 326.619 1.00 34.89  ? 225 LEU C C   1 
ATOM   6117 O O   . LEU C 3 225 ? 185.899 258.537 326.321 1.00 40.02  ? 225 LEU C O   1 
ATOM   6118 C CB  . LEU C 3 225 ? 187.393 255.890 325.366 1.00 30.61  ? 225 LEU C CB  1 
ATOM   6119 C CG  . LEU C 3 225 ? 188.071 255.243 326.575 1.00 31.67  ? 225 LEU C CG  1 
ATOM   6120 C CD1 . LEU C 3 225 ? 187.722 253.774 326.666 1.00 42.30  ? 225 LEU C CD1 1 
ATOM   6121 C CD2 . LEU C 3 225 ? 189.569 255.426 326.510 1.00 39.93  ? 225 LEU C CD2 1 
ATOM   6122 N N   . ARG C 3 226 ? 185.559 256.934 327.861 1.00 26.65  ? 226 ARG C N   1 
ATOM   6123 C CA  . ARG C 3 226 ? 185.443 257.860 328.978 1.00 21.64  ? 226 ARG C CA  1 
ATOM   6124 C C   . ARG C 3 226 ? 185.966 257.162 330.226 1.00 37.29  ? 226 ARG C C   1 
ATOM   6125 O O   . ARG C 3 226 ? 186.453 256.030 330.165 1.00 52.26  ? 226 ARG C O   1 
ATOM   6126 C CB  . ARG C 3 226 ? 183.993 258.323 329.149 1.00 29.66  ? 226 ARG C CB  1 
ATOM   6127 C CG  . ARG C 3 226 ? 183.070 257.254 329.708 1.00 40.77  ? 226 ARG C CG  1 
ATOM   6128 C CD  . ARG C 3 226 ? 181.632 257.725 329.752 1.00 40.55  ? 226 ARG C CD  1 
ATOM   6129 N NE  . ARG C 3 226 ? 180.750 256.729 330.346 1.00 37.22  ? 226 ARG C NE  1 
ATOM   6130 C CZ  . ARG C 3 226 ? 180.507 256.620 331.644 1.00 47.64  ? 226 ARG C CZ  1 
ATOM   6131 N NH1 . ARG C 3 226 ? 181.066 257.434 332.524 1.00 47.77  ? 226 ARG C NH1 1 
ATOM   6132 N NH2 . ARG C 3 226 ? 179.680 255.671 332.071 1.00 45.88  ? 226 ARG C NH2 1 
ATOM   6133 N N   . ASP C 3 227 ? 185.863 257.836 331.366 1.00 47.73  ? 227 ASP C N   1 
ATOM   6134 C CA  . ASP C 3 227 ? 186.270 257.254 332.634 1.00 49.64  ? 227 ASP C CA  1 
ATOM   6135 C C   . ASP C 3 227 ? 185.085 256.576 333.309 1.00 57.91  ? 227 ASP C C   1 
ATOM   6136 O O   . ASP C 3 227 ? 183.923 256.825 332.981 1.00 64.46  ? 227 ASP C O   1 
ATOM   6137 C CB  . ASP C 3 227 ? 186.855 258.319 333.562 1.00 57.25  ? 227 ASP C CB  1 
ATOM   6138 C CG  . ASP C 3 227 ? 188.339 258.539 333.340 1.00 64.17  ? 227 ASP C CG  1 
ATOM   6139 O OD1 . ASP C 3 227 ? 189.027 257.589 332.911 1.00 61.86  ? 227 ASP C OD1 1 
ATOM   6140 O OD2 . ASP C 3 227 ? 188.819 259.661 333.603 1.00 63.52  ? 227 ASP C OD2 1 
ATOM   6141 N N   . THR C 3 228 ? 185.397 255.713 334.269 1.00 60.22  ? 228 THR C N   1 
ATOM   6142 C CA  . THR C 3 228 ? 184.402 254.922 334.976 1.00 59.52  ? 228 THR C CA  1 
ATOM   6143 C C   . THR C 3 228 ? 184.234 255.445 336.394 1.00 56.52  ? 228 THR C C   1 
ATOM   6144 O O   . THR C 3 228 ? 185.206 255.861 337.032 1.00 56.56  ? 228 THR C O   1 
ATOM   6145 C CB  . THR C 3 228 ? 184.798 253.443 335.013 1.00 58.54  ? 228 THR C CB  1 
ATOM   6146 O OG1 . THR C 3 228 ? 183.843 252.709 335.787 1.00 58.17  ? 228 THR C OG1 1 
ATOM   6147 C CG2 . THR C 3 228 ? 186.183 253.267 335.619 1.00 60.84  ? 228 THR C CG2 1 
ATOM   6148 N N   . THR C 3 229 ? 182.997 255.426 336.880 1.00 58.64  ? 229 THR C N   1 
ATOM   6149 C CA  . THR C 3 229 ? 182.684 255.861 338.233 1.00 60.31  ? 229 THR C CA  1 
ATOM   6150 C C   . THR C 3 229 ? 182.695 254.720 339.240 1.00 62.99  ? 229 THR C C   1 
ATOM   6151 O O   . THR C 3 229 ? 182.430 254.956 340.423 1.00 60.77  ? 229 THR C O   1 
ATOM   6152 C CB  . THR C 3 229 ? 181.316 256.546 338.259 1.00 59.78  ? 229 THR C CB  1 
ATOM   6153 O OG1 . THR C 3 229 ? 180.320 255.651 337.751 1.00 61.83  ? 229 THR C OG1 1 
ATOM   6154 C CG2 . THR C 3 229 ? 181.334 257.805 337.414 1.00 62.42  ? 229 THR C CG2 1 
ATOM   6155 N N   . HIS C 3 230 ? 182.994 253.495 338.807 1.00 64.54  ? 230 HIS C N   1 
ATOM   6156 C CA  . HIS C 3 230 ? 182.960 252.350 339.707 1.00 59.55  ? 230 HIS C CA  1 
ATOM   6157 C C   . HIS C 3 230 ? 184.164 252.283 340.632 1.00 58.46  ? 230 HIS C C   1 
ATOM   6158 O O   . HIS C 3 230 ? 184.123 251.543 341.621 1.00 62.00  ? 230 HIS C O   1 
ATOM   6159 C CB  . HIS C 3 230 ? 182.883 251.051 338.904 1.00 60.68  ? 230 HIS C CB  1 
ATOM   6160 C CG  . HIS C 3 230 ? 181.670 250.950 338.036 1.00 60.14  ? 230 HIS C CG  1 
ATOM   6161 N ND1 . HIS C 3 230 ? 180.392 250.910 338.547 1.00 61.39  ? 230 HIS C ND1 1 
ATOM   6162 C CD2 . HIS C 3 230 ? 181.541 250.877 336.691 1.00 59.88  ? 230 HIS C CD2 1 
ATOM   6163 C CE1 . HIS C 3 230 ? 179.527 250.820 337.553 1.00 64.18  ? 230 HIS C CE1 1 
ATOM   6164 N NE2 . HIS C 3 230 ? 180.198 250.796 336.417 1.00 61.66  ? 230 HIS C NE2 1 
ATOM   6165 N N   . ILE C 3 231 ? 185.230 253.023 340.341 1.00 64.50  ? 231 ILE C N   1 
ATOM   6166 C CA  . ILE C 3 231 ? 186.463 252.963 341.114 1.00 70.70  ? 231 ILE C CA  1 
ATOM   6167 C C   . ILE C 3 231 ? 186.859 254.378 341.507 1.00 73.34  ? 231 ILE C C   1 
ATOM   6168 O O   . ILE C 3 231 ? 186.887 255.277 340.660 1.00 70.22  ? 231 ILE C O   1 
ATOM   6169 C CB  . ILE C 3 231 ? 187.594 252.280 340.322 1.00 68.46  ? 231 ILE C CB  1 
ATOM   6170 C CG1 . ILE C 3 231 ? 188.775 251.953 341.238 1.00 68.97  ? 231 ILE C CG1 1 
ATOM   6171 C CG2 . ILE C 3 231 ? 188.046 253.161 339.166 1.00 68.67  ? 231 ILE C CG2 1 
ATOM   6172 C CD1 . ILE C 3 231 ? 188.470 250.900 342.281 1.00 65.08  ? 231 ILE C CD1 1 
ATOM   6173 N N   . GLU C 3 232 ? 187.161 254.573 342.788 1.00 76.97  ? 232 GLU C N   1 
ATOM   6174 C CA  . GLU C 3 232 ? 187.594 255.863 343.306 1.00 77.96  ? 232 GLU C CA  1 
ATOM   6175 C C   . GLU C 3 232 ? 188.852 255.672 344.136 1.00 78.25  ? 232 GLU C C   1 
ATOM   6176 O O   . GLU C 3 232 ? 188.897 254.795 345.003 1.00 81.35  ? 232 GLU C O   1 
ATOM   6177 C CB  . GLU C 3 232 ? 186.503 256.517 344.158 1.00 78.09  ? 232 GLU C CB  1 
ATOM   6178 C CG  . GLU C 3 232 ? 185.245 256.874 343.393 1.00 80.00  ? 232 GLU C CG  1 
ATOM   6179 C CD  . GLU C 3 232 ? 184.374 257.862 344.144 1.00 82.61  ? 232 GLU C CD  1 
ATOM   6180 O OE1 . GLU C 3 232 ? 184.597 258.048 345.359 1.00 80.46  ? 232 GLU C OE1 1 
ATOM   6181 O OE2 . GLU C 3 232 ? 183.473 258.458 343.518 1.00 84.13  ? 232 GLU C OE2 1 
ATOM   6182 N N   . GLN C 3 233 ? 189.869 256.493 343.870 1.00 77.09  ? 233 GLN C N   1 
ATOM   6183 C CA  . GLN C 3 233 ? 191.092 256.491 344.671 1.00 75.72  ? 233 GLN C CA  1 
ATOM   6184 C C   . GLN C 3 233 ? 190.886 257.438 345.847 1.00 77.43  ? 233 GLN C C   1 
ATOM   6185 O O   . GLN C 3 233 ? 191.289 258.602 345.834 1.00 77.12  ? 233 GLN C O   1 
ATOM   6186 C CB  . GLN C 3 233 ? 192.298 256.889 343.831 1.00 75.38  ? 233 GLN C CB  1 
ATOM   6187 C CG  . GLN C 3 233 ? 193.588 256.966 344.631 1.00 73.50  ? 233 GLN C CG  1 
ATOM   6188 C CD  . GLN C 3 233 ? 194.826 256.868 343.764 1.00 77.91  ? 233 GLN C CD  1 
ATOM   6189 O OE1 . GLN C 3 233 ? 194.765 257.059 342.551 1.00 82.42  ? 233 GLN C OE1 1 
ATOM   6190 N NE2 . GLN C 3 233 ? 195.959 256.561 344.384 1.00 73.65  ? 233 GLN C NE2 1 
ATOM   6191 N N   . LYS C 3 234 ? 190.229 256.917 346.878 1.00 83.65  ? 234 LYS C N   1 
ATOM   6192 C CA  . LYS C 3 234 ? 189.958 257.667 348.096 1.00 82.99  ? 234 LYS C CA  1 
ATOM   6193 C C   . LYS C 3 234 ? 191.191 258.435 348.549 1.00 84.38  ? 234 LYS C C   1 
ATOM   6194 O O   . LYS C 3 234 ? 192.246 257.847 348.804 1.00 81.58  ? 234 LYS C O   1 
ATOM   6195 C CB  . LYS C 3 234 ? 189.500 256.705 349.195 1.00 81.62  ? 234 LYS C CB  1 
ATOM   6196 C CG  . LYS C 3 234 ? 190.458 255.548 349.439 1.00 83.42  ? 234 LYS C CG  1 
ATOM   6197 C CD  . LYS C 3 234 ? 189.803 254.427 350.226 1.00 83.20  ? 234 LYS C CD  1 
ATOM   6198 C CE  . LYS C 3 234 ? 190.701 253.201 350.283 1.00 82.26  ? 234 LYS C CE  1 
ATOM   6199 N NZ  . LYS C 3 234 ? 190.049 252.053 350.968 1.00 82.33  ? 234 LYS C NZ  1 
ATOM   6200 N N   . ALA C 3 235 ? 191.055 259.754 348.643 1.00 85.15  ? 235 ALA C N   1 
ATOM   6201 C CA  . ALA C 3 235 ? 192.171 260.619 349.005 1.00 81.93  ? 235 ALA C CA  1 
ATOM   6202 C C   . ALA C 3 235 ? 193.342 260.409 348.052 1.00 78.50  ? 235 ALA C C   1 
ATOM   6203 O O   . ALA C 3 235 ? 194.499 260.394 348.470 1.00 78.89  ? 235 ALA C O   1 
ATOM   6204 C CB  . ALA C 3 235 ? 192.601 260.363 350.438 1.00 81.04  ? 235 ALA C CB  1 
HETATM 6205 C C1  . PLM D 4 .   ? 204.848 248.388 333.560 1.00 65.16  ? 401 PLM A C1  1 
HETATM 6206 O O1  . PLM D 4 .   ? 203.769 247.773 333.345 1.00 66.83  ? 401 PLM A O1  1 
HETATM 6207 O O2  . PLM D 4 .   ? 205.478 248.522 334.645 1.00 63.67  ? 401 PLM A O2  1 
HETATM 6208 C C2  . PLM D 4 .   ? 205.470 249.067 332.292 1.00 61.46  ? 401 PLM A C2  1 
HETATM 6209 C C3  . PLM D 4 .   ? 206.610 250.053 332.548 1.00 53.16  ? 401 PLM A C3  1 
HETATM 6210 C C4  . PLM D 4 .   ? 207.831 249.441 333.235 1.00 56.08  ? 401 PLM A C4  1 
HETATM 6211 C C5  . PLM D 4 .   ? 209.102 249.500 332.386 1.00 57.76  ? 401 PLM A C5  1 
HETATM 6212 C C6  . PLM D 4 .   ? 209.619 250.909 332.126 1.00 54.10  ? 401 PLM A C6  1 
HETATM 6213 C C7  . PLM D 4 .   ? 211.085 251.109 332.506 1.00 58.71  ? 401 PLM A C7  1 
HETATM 6214 C C8  . PLM D 4 .   ? 211.732 252.309 331.821 1.00 58.37  ? 401 PLM A C8  1 
HETATM 6215 C C9  . PLM D 4 .   ? 210.929 253.599 331.953 1.00 54.62  ? 401 PLM A C9  1 
HETATM 6216 C CA  . PLM D 4 .   ? 211.793 254.852 331.978 1.00 60.14  ? 401 PLM A CA  1 
HETATM 6217 C CB  . PLM D 4 .   ? 212.454 255.144 330.637 1.00 60.72  ? 401 PLM A CB  1 
HETATM 6218 C CC  . PLM D 4 .   ? 213.721 255.964 330.753 1.00 56.56  ? 401 PLM A CC  1 
HETATM 6219 C CD  . PLM D 4 .   ? 213.516 257.267 331.504 1.00 54.73  ? 401 PLM A CD  1 
HETATM 6220 C CE  . PLM D 4 .   ? 214.632 258.282 331.256 1.00 59.70  ? 401 PLM A CE  1 
HETATM 6221 C CF  . PLM D 4 .   ? 214.331 259.666 331.810 1.00 60.65  ? 401 PLM A CF  1 
HETATM 6222 C CG  . PLM D 4 .   ? 213.653 259.623 333.175 1.00 59.05  ? 401 PLM A CG  1 
# 
