data_9EXM
# 
_entry.id   9EXM 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9EXM         pdb_00009exm 10.2210/pdb9exm/pdb 
WWPDB D_1292137610 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-21 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9EXM 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-08 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              gisela.branden@gu.se 
_pdbx_contact_author.name_first         Gisela 
_pdbx_contact_author.name_last          Branden 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5615-7187 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Dunge, A.'   1 0000-0003-2981-5759 
'Kack, H.'    2 0000-0002-5456-3269 
'Branden, G.' 3 0000-0001-5615-7187 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Cryogenic APO structures of soluble Epoxide Hydrolase.' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Dunge, A.'   1 0000-0003-2981-5759 
primary 'Kack, H.'    2 0000-0002-5456-3269 
primary 'Branden, G.' 3 0000-0001-5615-7187 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Bifunctional epoxide hydrolase 2' 62002.711 1   ? ? ? ? 
2 non-polymer syn GLYCEROL                           92.094    3   ? ? ? ? 
3 non-polymer syn 'SULFATE ION'                      96.063    1   ? ? ? ? 
4 non-polymer syn 'SODIUM ION'                       22.990    1   ? ? ? ? 
5 water       nat water                              18.015    619 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GMTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAK
VCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMV
KPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSH
GYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVT
FLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQ
NLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKS
LGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARN
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GMTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAK
VCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMV
KPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSH
GYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVT
FLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQ
NLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKS
LGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARN
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 GLYCEROL      GOL 
3 'SULFATE ION' SO4 
4 'SODIUM ION'  NA  
5 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   MET n 
1 3   THR n 
1 4   LEU n 
1 5   ARG n 
1 6   ALA n 
1 7   ALA n 
1 8   VAL n 
1 9   PHE n 
1 10  ASP n 
1 11  LEU n 
1 12  ASP n 
1 13  GLY n 
1 14  VAL n 
1 15  LEU n 
1 16  ALA n 
1 17  LEU n 
1 18  PRO n 
1 19  ALA n 
1 20  VAL n 
1 21  PHE n 
1 22  GLY n 
1 23  VAL n 
1 24  LEU n 
1 25  GLY n 
1 26  ARG n 
1 27  THR n 
1 28  GLU n 
1 29  GLU n 
1 30  ALA n 
1 31  LEU n 
1 32  ALA n 
1 33  LEU n 
1 34  PRO n 
1 35  ARG n 
1 36  GLY n 
1 37  LEU n 
1 38  LEU n 
1 39  ASN n 
1 40  ASP n 
1 41  ALA n 
1 42  PHE n 
1 43  GLN n 
1 44  LYS n 
1 45  GLY n 
1 46  GLY n 
1 47  PRO n 
1 48  GLU n 
1 49  GLY n 
1 50  ALA n 
1 51  THR n 
1 52  THR n 
1 53  ARG n 
1 54  LEU n 
1 55  MET n 
1 56  LYS n 
1 57  GLY n 
1 58  GLU n 
1 59  ILE n 
1 60  THR n 
1 61  LEU n 
1 62  SER n 
1 63  GLN n 
1 64  TRP n 
1 65  ILE n 
1 66  PRO n 
1 67  LEU n 
1 68  MET n 
1 69  GLU n 
1 70  GLU n 
1 71  ASN n 
1 72  CYS n 
1 73  ARG n 
1 74  LYS n 
1 75  CYS n 
1 76  SER n 
1 77  GLU n 
1 78  THR n 
1 79  ALA n 
1 80  LYS n 
1 81  VAL n 
1 82  CYS n 
1 83  LEU n 
1 84  PRO n 
1 85  LYS n 
1 86  ASN n 
1 87  PHE n 
1 88  SER n 
1 89  ILE n 
1 90  LYS n 
1 91  GLU n 
1 92  ILE n 
1 93  PHE n 
1 94  ASP n 
1 95  LYS n 
1 96  ALA n 
1 97  ILE n 
1 98  SER n 
1 99  ALA n 
1 100 ARG n 
1 101 LYS n 
1 102 ILE n 
1 103 ASN n 
1 104 ARG n 
1 105 PRO n 
1 106 MET n 
1 107 LEU n 
1 108 GLN n 
1 109 ALA n 
1 110 ALA n 
1 111 LEU n 
1 112 MET n 
1 113 LEU n 
1 114 ARG n 
1 115 LYS n 
1 116 LYS n 
1 117 GLY n 
1 118 PHE n 
1 119 THR n 
1 120 THR n 
1 121 ALA n 
1 122 ILE n 
1 123 LEU n 
1 124 THR n 
1 125 ASN n 
1 126 THR n 
1 127 TRP n 
1 128 LEU n 
1 129 ASP n 
1 130 ASP n 
1 131 ARG n 
1 132 ALA n 
1 133 GLU n 
1 134 ARG n 
1 135 ASP n 
1 136 GLY n 
1 137 LEU n 
1 138 ALA n 
1 139 GLN n 
1 140 LEU n 
1 141 MET n 
1 142 CYS n 
1 143 GLU n 
1 144 LEU n 
1 145 LYS n 
1 146 MET n 
1 147 HIS n 
1 148 PHE n 
1 149 ASP n 
1 150 PHE n 
1 151 LEU n 
1 152 ILE n 
1 153 GLU n 
1 154 SER n 
1 155 CYS n 
1 156 GLN n 
1 157 VAL n 
1 158 GLY n 
1 159 MET n 
1 160 VAL n 
1 161 LYS n 
1 162 PRO n 
1 163 GLU n 
1 164 PRO n 
1 165 GLN n 
1 166 ILE n 
1 167 TYR n 
1 168 LYS n 
1 169 PHE n 
1 170 LEU n 
1 171 LEU n 
1 172 ASP n 
1 173 THR n 
1 174 LEU n 
1 175 LYS n 
1 176 ALA n 
1 177 SER n 
1 178 PRO n 
1 179 SER n 
1 180 GLU n 
1 181 VAL n 
1 182 VAL n 
1 183 PHE n 
1 184 LEU n 
1 185 ASP n 
1 186 ASP n 
1 187 ILE n 
1 188 GLY n 
1 189 ALA n 
1 190 ASN n 
1 191 LEU n 
1 192 LYS n 
1 193 PRO n 
1 194 ALA n 
1 195 ARG n 
1 196 ASP n 
1 197 LEU n 
1 198 GLY n 
1 199 MET n 
1 200 VAL n 
1 201 THR n 
1 202 ILE n 
1 203 LEU n 
1 204 VAL n 
1 205 GLN n 
1 206 ASP n 
1 207 THR n 
1 208 ASP n 
1 209 THR n 
1 210 ALA n 
1 211 LEU n 
1 212 LYS n 
1 213 GLU n 
1 214 LEU n 
1 215 GLU n 
1 216 LYS n 
1 217 VAL n 
1 218 THR n 
1 219 GLY n 
1 220 ILE n 
1 221 GLN n 
1 222 LEU n 
1 223 LEU n 
1 224 ASN n 
1 225 THR n 
1 226 PRO n 
1 227 ALA n 
1 228 PRO n 
1 229 LEU n 
1 230 PRO n 
1 231 THR n 
1 232 SER n 
1 233 CYS n 
1 234 ASN n 
1 235 PRO n 
1 236 SER n 
1 237 ASP n 
1 238 MET n 
1 239 SER n 
1 240 HIS n 
1 241 GLY n 
1 242 TYR n 
1 243 VAL n 
1 244 THR n 
1 245 VAL n 
1 246 LYS n 
1 247 PRO n 
1 248 ARG n 
1 249 VAL n 
1 250 ARG n 
1 251 LEU n 
1 252 HIS n 
1 253 PHE n 
1 254 VAL n 
1 255 GLU n 
1 256 LEU n 
1 257 GLY n 
1 258 SER n 
1 259 GLY n 
1 260 PRO n 
1 261 ALA n 
1 262 VAL n 
1 263 CYS n 
1 264 LEU n 
1 265 CYS n 
1 266 HIS n 
1 267 GLY n 
1 268 PHE n 
1 269 PRO n 
1 270 GLU n 
1 271 SER n 
1 272 TRP n 
1 273 TYR n 
1 274 SER n 
1 275 TRP n 
1 276 ARG n 
1 277 TYR n 
1 278 GLN n 
1 279 ILE n 
1 280 PRO n 
1 281 ALA n 
1 282 LEU n 
1 283 ALA n 
1 284 GLN n 
1 285 ALA n 
1 286 GLY n 
1 287 TYR n 
1 288 ARG n 
1 289 VAL n 
1 290 LEU n 
1 291 ALA n 
1 292 MET n 
1 293 ASP n 
1 294 MET n 
1 295 LYS n 
1 296 GLY n 
1 297 TYR n 
1 298 GLY n 
1 299 GLU n 
1 300 SER n 
1 301 SER n 
1 302 ALA n 
1 303 PRO n 
1 304 PRO n 
1 305 GLU n 
1 306 ILE n 
1 307 GLU n 
1 308 GLU n 
1 309 TYR n 
1 310 CYS n 
1 311 MET n 
1 312 GLU n 
1 313 VAL n 
1 314 LEU n 
1 315 CYS n 
1 316 LYS n 
1 317 GLU n 
1 318 MET n 
1 319 VAL n 
1 320 THR n 
1 321 PHE n 
1 322 LEU n 
1 323 ASP n 
1 324 LYS n 
1 325 LEU n 
1 326 GLY n 
1 327 LEU n 
1 328 SER n 
1 329 GLN n 
1 330 ALA n 
1 331 VAL n 
1 332 PHE n 
1 333 ILE n 
1 334 GLY n 
1 335 HIS n 
1 336 ASP n 
1 337 TRP n 
1 338 GLY n 
1 339 GLY n 
1 340 MET n 
1 341 LEU n 
1 342 VAL n 
1 343 TRP n 
1 344 TYR n 
1 345 MET n 
1 346 ALA n 
1 347 LEU n 
1 348 PHE n 
1 349 TYR n 
1 350 PRO n 
1 351 GLU n 
1 352 ARG n 
1 353 VAL n 
1 354 ARG n 
1 355 ALA n 
1 356 VAL n 
1 357 ALA n 
1 358 SER n 
1 359 LEU n 
1 360 ASN n 
1 361 THR n 
1 362 PRO n 
1 363 PHE n 
1 364 ILE n 
1 365 PRO n 
1 366 ALA n 
1 367 ASN n 
1 368 PRO n 
1 369 ASN n 
1 370 MET n 
1 371 SER n 
1 372 PRO n 
1 373 LEU n 
1 374 GLU n 
1 375 SER n 
1 376 ILE n 
1 377 LYS n 
1 378 ALA n 
1 379 ASN n 
1 380 PRO n 
1 381 VAL n 
1 382 PHE n 
1 383 ASP n 
1 384 TYR n 
1 385 GLN n 
1 386 LEU n 
1 387 TYR n 
1 388 PHE n 
1 389 GLN n 
1 390 GLU n 
1 391 PRO n 
1 392 GLY n 
1 393 VAL n 
1 394 ALA n 
1 395 GLU n 
1 396 ALA n 
1 397 GLU n 
1 398 LEU n 
1 399 GLU n 
1 400 GLN n 
1 401 ASN n 
1 402 LEU n 
1 403 SER n 
1 404 ARG n 
1 405 THR n 
1 406 PHE n 
1 407 LYS n 
1 408 SER n 
1 409 LEU n 
1 410 PHE n 
1 411 ARG n 
1 412 ALA n 
1 413 SER n 
1 414 ASP n 
1 415 GLU n 
1 416 SER n 
1 417 VAL n 
1 418 LEU n 
1 419 SER n 
1 420 MET n 
1 421 HIS n 
1 422 LYS n 
1 423 VAL n 
1 424 CYS n 
1 425 GLU n 
1 426 ALA n 
1 427 GLY n 
1 428 GLY n 
1 429 LEU n 
1 430 PHE n 
1 431 VAL n 
1 432 ASN n 
1 433 SER n 
1 434 PRO n 
1 435 GLU n 
1 436 GLU n 
1 437 PRO n 
1 438 SER n 
1 439 LEU n 
1 440 SER n 
1 441 ARG n 
1 442 MET n 
1 443 VAL n 
1 444 THR n 
1 445 GLU n 
1 446 GLU n 
1 447 GLU n 
1 448 ILE n 
1 449 GLN n 
1 450 PHE n 
1 451 TYR n 
1 452 VAL n 
1 453 GLN n 
1 454 GLN n 
1 455 PHE n 
1 456 LYS n 
1 457 LYS n 
1 458 SER n 
1 459 GLY n 
1 460 PHE n 
1 461 ARG n 
1 462 GLY n 
1 463 PRO n 
1 464 LEU n 
1 465 ASN n 
1 466 TRP n 
1 467 TYR n 
1 468 ARG n 
1 469 ASN n 
1 470 MET n 
1 471 GLU n 
1 472 ARG n 
1 473 ASN n 
1 474 TRP n 
1 475 LYS n 
1 476 TRP n 
1 477 ALA n 
1 478 CYS n 
1 479 LYS n 
1 480 SER n 
1 481 LEU n 
1 482 GLY n 
1 483 ARG n 
1 484 LYS n 
1 485 ILE n 
1 486 LEU n 
1 487 ILE n 
1 488 PRO n 
1 489 ALA n 
1 490 LEU n 
1 491 MET n 
1 492 VAL n 
1 493 THR n 
1 494 ALA n 
1 495 GLU n 
1 496 LYS n 
1 497 ASP n 
1 498 PHE n 
1 499 VAL n 
1 500 LEU n 
1 501 VAL n 
1 502 PRO n 
1 503 GLN n 
1 504 MET n 
1 505 SER n 
1 506 GLN n 
1 507 HIS n 
1 508 MET n 
1 509 GLU n 
1 510 ASP n 
1 511 TRP n 
1 512 ILE n 
1 513 PRO n 
1 514 HIS n 
1 515 LEU n 
1 516 LYS n 
1 517 ARG n 
1 518 GLY n 
1 519 HIS n 
1 520 ILE n 
1 521 GLU n 
1 522 ASP n 
1 523 CYS n 
1 524 GLY n 
1 525 HIS n 
1 526 TRP n 
1 527 THR n 
1 528 GLN n 
1 529 MET n 
1 530 ASP n 
1 531 LYS n 
1 532 PRO n 
1 533 THR n 
1 534 GLU n 
1 535 VAL n 
1 536 ASN n 
1 537 GLN n 
1 538 ILE n 
1 539 LEU n 
1 540 ILE n 
1 541 LYS n 
1 542 TRP n 
1 543 LEU n 
1 544 ASP n 
1 545 SER n 
1 546 ASP n 
1 547 ALA n 
1 548 ARG n 
1 549 ASN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   549 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 EPHX2 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE       ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                               'C5 H11 N O2 S'  149.211 
NA  non-polymer         . 'SODIUM ION'    ?                               'Na 1'           22.990  
PHE 'L-peptide linking' y PHENYLALANINE   ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                               'C3 H7 N O3'     105.093 
SO4 non-polymer         . 'SULFATE ION'   ?                               'O4 S -2'        96.063  
THR 'L-peptide linking' y THREONINE       ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   0   ?   ?   ?   A . n 
A 1 2   MET 2   1   ?   ?   ?   A . n 
A 1 3   THR 3   2   2   THR THR A . n 
A 1 4   LEU 4   3   3   LEU LEU A . n 
A 1 5   ARG 5   4   4   ARG ARG A . n 
A 1 6   ALA 6   5   5   ALA ALA A . n 
A 1 7   ALA 7   6   6   ALA ALA A . n 
A 1 8   VAL 8   7   7   VAL VAL A . n 
A 1 9   PHE 9   8   8   PHE PHE A . n 
A 1 10  ASP 10  9   9   ASP ASP A . n 
A 1 11  LEU 11  10  10  LEU LEU A . n 
A 1 12  ASP 12  11  11  ASP ASP A . n 
A 1 13  GLY 13  12  12  GLY GLY A . n 
A 1 14  VAL 14  13  13  VAL VAL A . n 
A 1 15  LEU 15  14  14  LEU LEU A . n 
A 1 16  ALA 16  15  15  ALA ALA A . n 
A 1 17  LEU 17  16  16  LEU LEU A . n 
A 1 18  PRO 18  17  17  PRO PRO A . n 
A 1 19  ALA 19  18  18  ALA ALA A . n 
A 1 20  VAL 20  19  19  VAL VAL A . n 
A 1 21  PHE 21  20  20  PHE PHE A . n 
A 1 22  GLY 22  21  21  GLY GLY A . n 
A 1 23  VAL 23  22  22  VAL VAL A . n 
A 1 24  LEU 24  23  23  LEU LEU A . n 
A 1 25  GLY 25  24  24  GLY GLY A . n 
A 1 26  ARG 26  25  25  ARG ARG A . n 
A 1 27  THR 27  26  26  THR THR A . n 
A 1 28  GLU 28  27  27  GLU GLU A . n 
A 1 29  GLU 29  28  28  GLU GLU A . n 
A 1 30  ALA 30  29  29  ALA ALA A . n 
A 1 31  LEU 31  30  30  LEU LEU A . n 
A 1 32  ALA 32  31  31  ALA ALA A . n 
A 1 33  LEU 33  32  32  LEU LEU A . n 
A 1 34  PRO 34  33  33  PRO PRO A . n 
A 1 35  ARG 35  34  34  ARG ARG A . n 
A 1 36  GLY 36  35  35  GLY GLY A . n 
A 1 37  LEU 37  36  36  LEU LEU A . n 
A 1 38  LEU 38  37  37  LEU LEU A . n 
A 1 39  ASN 39  38  38  ASN ASN A . n 
A 1 40  ASP 40  39  39  ASP ASP A . n 
A 1 41  ALA 41  40  40  ALA ALA A . n 
A 1 42  PHE 42  41  41  PHE PHE A . n 
A 1 43  GLN 43  42  42  GLN GLN A . n 
A 1 44  LYS 44  43  43  LYS LYS A . n 
A 1 45  GLY 45  44  44  GLY GLY A . n 
A 1 46  GLY 46  45  45  GLY GLY A . n 
A 1 47  PRO 47  46  46  PRO PRO A . n 
A 1 48  GLU 48  47  47  GLU GLU A . n 
A 1 49  GLY 49  48  48  GLY GLY A . n 
A 1 50  ALA 50  49  49  ALA ALA A . n 
A 1 51  THR 51  50  50  THR THR A . n 
A 1 52  THR 52  51  51  THR THR A . n 
A 1 53  ARG 53  52  52  ARG ARG A . n 
A 1 54  LEU 54  53  53  LEU LEU A . n 
A 1 55  MET 55  54  54  MET MET A . n 
A 1 56  LYS 56  55  55  LYS LYS A . n 
A 1 57  GLY 57  56  56  GLY GLY A . n 
A 1 58  GLU 58  57  57  GLU GLU A . n 
A 1 59  ILE 59  58  58  ILE ILE A . n 
A 1 60  THR 60  59  59  THR THR A . n 
A 1 61  LEU 61  60  60  LEU LEU A . n 
A 1 62  SER 62  61  61  SER SER A . n 
A 1 63  GLN 63  62  62  GLN GLN A . n 
A 1 64  TRP 64  63  63  TRP TRP A . n 
A 1 65  ILE 65  64  64  ILE ILE A . n 
A 1 66  PRO 66  65  65  PRO PRO A . n 
A 1 67  LEU 67  66  66  LEU LEU A . n 
A 1 68  MET 68  67  67  MET MET A . n 
A 1 69  GLU 69  68  68  GLU GLU A . n 
A 1 70  GLU 70  69  69  GLU GLU A . n 
A 1 71  ASN 71  70  70  ASN ASN A . n 
A 1 72  CYS 72  71  71  CYS CYS A . n 
A 1 73  ARG 73  72  72  ARG ARG A . n 
A 1 74  LYS 74  73  73  LYS LYS A . n 
A 1 75  CYS 75  74  74  CYS CYS A . n 
A 1 76  SER 76  75  75  SER SER A . n 
A 1 77  GLU 77  76  76  GLU GLU A . n 
A 1 78  THR 78  77  77  THR THR A . n 
A 1 79  ALA 79  78  78  ALA ALA A . n 
A 1 80  LYS 80  79  79  LYS LYS A . n 
A 1 81  VAL 81  80  80  VAL VAL A . n 
A 1 82  CYS 82  81  81  CYS CYS A . n 
A 1 83  LEU 83  82  82  LEU LEU A . n 
A 1 84  PRO 84  83  83  PRO PRO A . n 
A 1 85  LYS 85  84  84  LYS LYS A . n 
A 1 86  ASN 86  85  85  ASN ASN A . n 
A 1 87  PHE 87  86  86  PHE PHE A . n 
A 1 88  SER 88  87  87  SER SER A . n 
A 1 89  ILE 89  88  88  ILE ILE A . n 
A 1 90  LYS 90  89  89  LYS LYS A . n 
A 1 91  GLU 91  90  90  GLU GLU A . n 
A 1 92  ILE 92  91  91  ILE ILE A . n 
A 1 93  PHE 93  92  92  PHE PHE A . n 
A 1 94  ASP 94  93  93  ASP ASP A . n 
A 1 95  LYS 95  94  94  LYS LYS A . n 
A 1 96  ALA 96  95  95  ALA ALA A . n 
A 1 97  ILE 97  96  96  ILE ILE A . n 
A 1 98  SER 98  97  97  SER SER A . n 
A 1 99  ALA 99  98  98  ALA ALA A . n 
A 1 100 ARG 100 99  99  ARG ARG A . n 
A 1 101 LYS 101 100 100 LYS LYS A . n 
A 1 102 ILE 102 101 101 ILE ILE A . n 
A 1 103 ASN 103 102 102 ASN ASN A . n 
A 1 104 ARG 104 103 103 ARG ARG A . n 
A 1 105 PRO 105 104 104 PRO PRO A . n 
A 1 106 MET 106 105 105 MET MET A . n 
A 1 107 LEU 107 106 106 LEU LEU A . n 
A 1 108 GLN 108 107 107 GLN GLN A . n 
A 1 109 ALA 109 108 108 ALA ALA A . n 
A 1 110 ALA 110 109 109 ALA ALA A . n 
A 1 111 LEU 111 110 110 LEU LEU A . n 
A 1 112 MET 112 111 111 MET MET A . n 
A 1 113 LEU 113 112 112 LEU LEU A . n 
A 1 114 ARG 114 113 113 ARG ARG A . n 
A 1 115 LYS 115 114 114 LYS LYS A . n 
A 1 116 LYS 116 115 115 LYS LYS A . n 
A 1 117 GLY 117 116 116 GLY GLY A . n 
A 1 118 PHE 118 117 117 PHE PHE A . n 
A 1 119 THR 119 118 118 THR THR A . n 
A 1 120 THR 120 119 119 THR THR A . n 
A 1 121 ALA 121 120 120 ALA ALA A . n 
A 1 122 ILE 122 121 121 ILE ILE A . n 
A 1 123 LEU 123 122 122 LEU LEU A . n 
A 1 124 THR 124 123 123 THR THR A . n 
A 1 125 ASN 125 124 124 ASN ASN A . n 
A 1 126 THR 126 125 125 THR THR A . n 
A 1 127 TRP 127 126 126 TRP TRP A . n 
A 1 128 LEU 128 127 127 LEU LEU A . n 
A 1 129 ASP 129 128 128 ASP ASP A . n 
A 1 130 ASP 130 129 129 ASP ASP A . n 
A 1 131 ARG 131 130 130 ARG ARG A . n 
A 1 132 ALA 132 131 131 ALA ALA A . n 
A 1 133 GLU 133 132 132 GLU GLU A . n 
A 1 134 ARG 134 133 133 ARG ARG A . n 
A 1 135 ASP 135 134 134 ASP ASP A . n 
A 1 136 GLY 136 135 135 GLY GLY A . n 
A 1 137 LEU 137 136 136 LEU LEU A . n 
A 1 138 ALA 138 137 137 ALA ALA A . n 
A 1 139 GLN 139 138 138 GLN GLN A . n 
A 1 140 LEU 140 139 139 LEU LEU A . n 
A 1 141 MET 141 140 140 MET MET A . n 
A 1 142 CYS 142 141 141 CYS CYS A . n 
A 1 143 GLU 143 142 142 GLU GLU A . n 
A 1 144 LEU 144 143 143 LEU LEU A . n 
A 1 145 LYS 145 144 144 LYS LYS A . n 
A 1 146 MET 146 145 145 MET MET A . n 
A 1 147 HIS 147 146 146 HIS HIS A . n 
A 1 148 PHE 148 147 147 PHE PHE A . n 
A 1 149 ASP 149 148 148 ASP ASP A . n 
A 1 150 PHE 150 149 149 PHE PHE A . n 
A 1 151 LEU 151 150 150 LEU LEU A . n 
A 1 152 ILE 152 151 151 ILE ILE A . n 
A 1 153 GLU 153 152 152 GLU GLU A . n 
A 1 154 SER 154 153 153 SER SER A . n 
A 1 155 CYS 155 154 154 CYS CYS A . n 
A 1 156 GLN 156 155 155 GLN GLN A . n 
A 1 157 VAL 157 156 156 VAL VAL A . n 
A 1 158 GLY 158 157 157 GLY GLY A . n 
A 1 159 MET 159 158 158 MET MET A . n 
A 1 160 VAL 160 159 159 VAL VAL A . n 
A 1 161 LYS 161 160 160 LYS LYS A . n 
A 1 162 PRO 162 161 161 PRO PRO A . n 
A 1 163 GLU 163 162 162 GLU GLU A . n 
A 1 164 PRO 164 163 163 PRO PRO A . n 
A 1 165 GLN 165 164 164 GLN GLN A . n 
A 1 166 ILE 166 165 165 ILE ILE A . n 
A 1 167 TYR 167 166 166 TYR TYR A . n 
A 1 168 LYS 168 167 167 LYS LYS A . n 
A 1 169 PHE 169 168 168 PHE PHE A . n 
A 1 170 LEU 170 169 169 LEU LEU A . n 
A 1 171 LEU 171 170 170 LEU LEU A . n 
A 1 172 ASP 172 171 171 ASP ASP A . n 
A 1 173 THR 173 172 172 THR THR A . n 
A 1 174 LEU 174 173 173 LEU LEU A . n 
A 1 175 LYS 175 174 174 LYS LYS A . n 
A 1 176 ALA 176 175 175 ALA ALA A . n 
A 1 177 SER 177 176 176 SER SER A . n 
A 1 178 PRO 178 177 177 PRO PRO A . n 
A 1 179 SER 179 178 178 SER SER A . n 
A 1 180 GLU 180 179 179 GLU GLU A . n 
A 1 181 VAL 181 180 180 VAL VAL A . n 
A 1 182 VAL 182 181 181 VAL VAL A . n 
A 1 183 PHE 183 182 182 PHE PHE A . n 
A 1 184 LEU 184 183 183 LEU LEU A . n 
A 1 185 ASP 185 184 184 ASP ASP A . n 
A 1 186 ASP 186 185 185 ASP ASP A . n 
A 1 187 ILE 187 186 186 ILE ILE A . n 
A 1 188 GLY 188 187 187 GLY GLY A . n 
A 1 189 ALA 189 188 188 ALA ALA A . n 
A 1 190 ASN 190 189 189 ASN ASN A . n 
A 1 191 LEU 191 190 190 LEU LEU A . n 
A 1 192 LYS 192 191 191 LYS LYS A . n 
A 1 193 PRO 193 192 192 PRO PRO A . n 
A 1 194 ALA 194 193 193 ALA ALA A . n 
A 1 195 ARG 195 194 194 ARG ARG A . n 
A 1 196 ASP 196 195 195 ASP ASP A . n 
A 1 197 LEU 197 196 196 LEU LEU A . n 
A 1 198 GLY 198 197 197 GLY GLY A . n 
A 1 199 MET 199 198 198 MET MET A . n 
A 1 200 VAL 200 199 199 VAL VAL A . n 
A 1 201 THR 201 200 200 THR THR A . n 
A 1 202 ILE 202 201 201 ILE ILE A . n 
A 1 203 LEU 203 202 202 LEU LEU A . n 
A 1 204 VAL 204 203 203 VAL VAL A . n 
A 1 205 GLN 205 204 204 GLN GLN A . n 
A 1 206 ASP 206 205 205 ASP ASP A . n 
A 1 207 THR 207 206 206 THR THR A . n 
A 1 208 ASP 208 207 207 ASP ASP A . n 
A 1 209 THR 209 208 208 THR THR A . n 
A 1 210 ALA 210 209 209 ALA ALA A . n 
A 1 211 LEU 211 210 210 LEU LEU A . n 
A 1 212 LYS 212 211 211 LYS LYS A . n 
A 1 213 GLU 213 212 212 GLU GLU A . n 
A 1 214 LEU 214 213 213 LEU LEU A . n 
A 1 215 GLU 215 214 214 GLU GLU A . n 
A 1 216 LYS 216 215 215 LYS LYS A . n 
A 1 217 VAL 217 216 216 VAL VAL A . n 
A 1 218 THR 218 217 217 THR THR A . n 
A 1 219 GLY 219 218 218 GLY GLY A . n 
A 1 220 ILE 220 219 219 ILE ILE A . n 
A 1 221 GLN 221 220 220 GLN GLN A . n 
A 1 222 LEU 222 221 221 LEU LEU A . n 
A 1 223 LEU 223 222 222 LEU LEU A . n 
A 1 224 ASN 224 223 223 ASN ASN A . n 
A 1 225 THR 225 224 224 THR THR A . n 
A 1 226 PRO 226 225 225 PRO PRO A . n 
A 1 227 ALA 227 226 226 ALA ALA A . n 
A 1 228 PRO 228 227 227 PRO PRO A . n 
A 1 229 LEU 229 228 228 LEU LEU A . n 
A 1 230 PRO 230 229 229 PRO PRO A . n 
A 1 231 THR 231 230 230 THR THR A . n 
A 1 232 SER 232 231 231 SER SER A . n 
A 1 233 CYS 233 232 232 CYS CYS A . n 
A 1 234 ASN 234 233 233 ASN ASN A . n 
A 1 235 PRO 235 234 234 PRO PRO A . n 
A 1 236 SER 236 235 235 SER SER A . n 
A 1 237 ASP 237 236 236 ASP ASP A . n 
A 1 238 MET 238 237 237 MET MET A . n 
A 1 239 SER 239 238 238 SER SER A . n 
A 1 240 HIS 240 239 239 HIS HIS A . n 
A 1 241 GLY 241 240 240 GLY GLY A . n 
A 1 242 TYR 242 241 241 TYR TYR A . n 
A 1 243 VAL 243 242 242 VAL VAL A . n 
A 1 244 THR 244 243 243 THR THR A . n 
A 1 245 VAL 245 244 244 VAL VAL A . n 
A 1 246 LYS 246 245 245 LYS LYS A . n 
A 1 247 PRO 247 246 246 PRO PRO A . n 
A 1 248 ARG 248 247 247 ARG ARG A . n 
A 1 249 VAL 249 248 248 VAL VAL A . n 
A 1 250 ARG 250 249 249 ARG ARG A . n 
A 1 251 LEU 251 250 250 LEU LEU A . n 
A 1 252 HIS 252 251 251 HIS HIS A . n 
A 1 253 PHE 253 252 252 PHE PHE A . n 
A 1 254 VAL 254 253 253 VAL VAL A . n 
A 1 255 GLU 255 254 254 GLU GLU A . n 
A 1 256 LEU 256 255 255 LEU LEU A . n 
A 1 257 GLY 257 256 256 GLY GLY A . n 
A 1 258 SER 258 257 257 SER SER A . n 
A 1 259 GLY 259 258 258 GLY GLY A . n 
A 1 260 PRO 260 259 259 PRO PRO A . n 
A 1 261 ALA 261 260 260 ALA ALA A . n 
A 1 262 VAL 262 261 261 VAL VAL A . n 
A 1 263 CYS 263 262 262 CYS CYS A . n 
A 1 264 LEU 264 263 263 LEU LEU A . n 
A 1 265 CYS 265 264 264 CYS CYS A . n 
A 1 266 HIS 266 265 265 HIS HIS A . n 
A 1 267 GLY 267 266 266 GLY GLY A . n 
A 1 268 PHE 268 267 267 PHE PHE A . n 
A 1 269 PRO 269 268 268 PRO PRO A . n 
A 1 270 GLU 270 269 269 GLU GLU A . n 
A 1 271 SER 271 270 270 SER SER A . n 
A 1 272 TRP 272 271 271 TRP TRP A . n 
A 1 273 TYR 273 272 272 TYR TYR A . n 
A 1 274 SER 274 273 273 SER SER A . n 
A 1 275 TRP 275 274 274 TRP TRP A . n 
A 1 276 ARG 276 275 275 ARG ARG A . n 
A 1 277 TYR 277 276 276 TYR TYR A . n 
A 1 278 GLN 278 277 277 GLN GLN A . n 
A 1 279 ILE 279 278 278 ILE ILE A . n 
A 1 280 PRO 280 279 279 PRO PRO A . n 
A 1 281 ALA 281 280 280 ALA ALA A . n 
A 1 282 LEU 282 281 281 LEU LEU A . n 
A 1 283 ALA 283 282 282 ALA ALA A . n 
A 1 284 GLN 284 283 283 GLN GLN A . n 
A 1 285 ALA 285 284 284 ALA ALA A . n 
A 1 286 GLY 286 285 285 GLY GLY A . n 
A 1 287 TYR 287 286 286 TYR TYR A . n 
A 1 288 ARG 288 287 287 ARG ARG A . n 
A 1 289 VAL 289 288 288 VAL VAL A . n 
A 1 290 LEU 290 289 289 LEU LEU A . n 
A 1 291 ALA 291 290 290 ALA ALA A . n 
A 1 292 MET 292 291 291 MET MET A . n 
A 1 293 ASP 293 292 292 ASP ASP A . n 
A 1 294 MET 294 293 293 MET MET A . n 
A 1 295 LYS 295 294 294 LYS LYS A . n 
A 1 296 GLY 296 295 295 GLY GLY A . n 
A 1 297 TYR 297 296 296 TYR TYR A . n 
A 1 298 GLY 298 297 297 GLY GLY A . n 
A 1 299 GLU 299 298 298 GLU GLU A . n 
A 1 300 SER 300 299 299 SER SER A . n 
A 1 301 SER 301 300 300 SER SER A . n 
A 1 302 ALA 302 301 301 ALA ALA A . n 
A 1 303 PRO 303 302 302 PRO PRO A . n 
A 1 304 PRO 304 303 303 PRO PRO A . n 
A 1 305 GLU 305 304 304 GLU GLU A . n 
A 1 306 ILE 306 305 305 ILE ILE A . n 
A 1 307 GLU 307 306 306 GLU GLU A . n 
A 1 308 GLU 308 307 307 GLU GLU A . n 
A 1 309 TYR 309 308 308 TYR TYR A . n 
A 1 310 CYS 310 309 309 CYS CYS A . n 
A 1 311 MET 311 310 310 MET MET A . n 
A 1 312 GLU 312 311 311 GLU GLU A . n 
A 1 313 VAL 313 312 312 VAL VAL A . n 
A 1 314 LEU 314 313 313 LEU LEU A . n 
A 1 315 CYS 315 314 314 CYS CYS A . n 
A 1 316 LYS 316 315 315 LYS LYS A . n 
A 1 317 GLU 317 316 316 GLU GLU A . n 
A 1 318 MET 318 317 317 MET MET A . n 
A 1 319 VAL 319 318 318 VAL VAL A . n 
A 1 320 THR 320 319 319 THR THR A . n 
A 1 321 PHE 321 320 320 PHE PHE A . n 
A 1 322 LEU 322 321 321 LEU LEU A . n 
A 1 323 ASP 323 322 322 ASP ASP A . n 
A 1 324 LYS 324 323 323 LYS LYS A . n 
A 1 325 LEU 325 324 324 LEU LEU A . n 
A 1 326 GLY 326 325 325 GLY GLY A . n 
A 1 327 LEU 327 326 326 LEU LEU A . n 
A 1 328 SER 328 327 327 SER SER A . n 
A 1 329 GLN 329 328 328 GLN GLN A . n 
A 1 330 ALA 330 329 329 ALA ALA A . n 
A 1 331 VAL 331 330 330 VAL VAL A . n 
A 1 332 PHE 332 331 331 PHE PHE A . n 
A 1 333 ILE 333 332 332 ILE ILE A . n 
A 1 334 GLY 334 333 333 GLY GLY A . n 
A 1 335 HIS 335 334 334 HIS HIS A . n 
A 1 336 ASP 336 335 335 ASP ASP A . n 
A 1 337 TRP 337 336 336 TRP TRP A . n 
A 1 338 GLY 338 337 337 GLY GLY A . n 
A 1 339 GLY 339 338 338 GLY GLY A . n 
A 1 340 MET 340 339 339 MET MET A . n 
A 1 341 LEU 341 340 340 LEU LEU A . n 
A 1 342 VAL 342 341 341 VAL VAL A . n 
A 1 343 TRP 343 342 342 TRP TRP A . n 
A 1 344 TYR 344 343 343 TYR TYR A . n 
A 1 345 MET 345 344 344 MET MET A . n 
A 1 346 ALA 346 345 345 ALA ALA A . n 
A 1 347 LEU 347 346 346 LEU LEU A . n 
A 1 348 PHE 348 347 347 PHE PHE A . n 
A 1 349 TYR 349 348 348 TYR TYR A . n 
A 1 350 PRO 350 349 349 PRO PRO A . n 
A 1 351 GLU 351 350 350 GLU GLU A . n 
A 1 352 ARG 352 351 351 ARG ARG A . n 
A 1 353 VAL 353 352 352 VAL VAL A . n 
A 1 354 ARG 354 353 353 ARG ARG A . n 
A 1 355 ALA 355 354 354 ALA ALA A . n 
A 1 356 VAL 356 355 355 VAL VAL A . n 
A 1 357 ALA 357 356 356 ALA ALA A . n 
A 1 358 SER 358 357 357 SER SER A . n 
A 1 359 LEU 359 358 358 LEU LEU A . n 
A 1 360 ASN 360 359 359 ASN ASN A . n 
A 1 361 THR 361 360 360 THR THR A . n 
A 1 362 PRO 362 361 361 PRO PRO A . n 
A 1 363 PHE 363 362 362 PHE PHE A . n 
A 1 364 ILE 364 363 363 ILE ILE A . n 
A 1 365 PRO 365 364 364 PRO PRO A . n 
A 1 366 ALA 366 365 365 ALA ALA A . n 
A 1 367 ASN 367 366 366 ASN ASN A . n 
A 1 368 PRO 368 367 367 PRO PRO A . n 
A 1 369 ASN 369 368 368 ASN ASN A . n 
A 1 370 MET 370 369 369 MET MET A . n 
A 1 371 SER 371 370 370 SER SER A . n 
A 1 372 PRO 372 371 371 PRO PRO A . n 
A 1 373 LEU 373 372 372 LEU LEU A . n 
A 1 374 GLU 374 373 373 GLU GLU A . n 
A 1 375 SER 375 374 374 SER SER A . n 
A 1 376 ILE 376 375 375 ILE ILE A . n 
A 1 377 LYS 377 376 376 LYS LYS A . n 
A 1 378 ALA 378 377 377 ALA ALA A . n 
A 1 379 ASN 379 378 378 ASN ASN A . n 
A 1 380 PRO 380 379 379 PRO PRO A . n 
A 1 381 VAL 381 380 380 VAL VAL A . n 
A 1 382 PHE 382 381 381 PHE PHE A . n 
A 1 383 ASP 383 382 382 ASP ASP A . n 
A 1 384 TYR 384 383 383 TYR TYR A . n 
A 1 385 GLN 385 384 384 GLN GLN A . n 
A 1 386 LEU 386 385 385 LEU LEU A . n 
A 1 387 TYR 387 386 386 TYR TYR A . n 
A 1 388 PHE 388 387 387 PHE PHE A . n 
A 1 389 GLN 389 388 388 GLN GLN A . n 
A 1 390 GLU 390 389 389 GLU GLU A . n 
A 1 391 PRO 391 390 390 PRO PRO A . n 
A 1 392 GLY 392 391 391 GLY GLY A . n 
A 1 393 VAL 393 392 392 VAL VAL A . n 
A 1 394 ALA 394 393 393 ALA ALA A . n 
A 1 395 GLU 395 394 394 GLU GLU A . n 
A 1 396 ALA 396 395 395 ALA ALA A . n 
A 1 397 GLU 397 396 396 GLU GLU A . n 
A 1 398 LEU 398 397 397 LEU LEU A . n 
A 1 399 GLU 399 398 398 GLU GLU A . n 
A 1 400 GLN 400 399 399 GLN GLN A . n 
A 1 401 ASN 401 400 400 ASN ASN A . n 
A 1 402 LEU 402 401 401 LEU LEU A . n 
A 1 403 SER 403 402 402 SER SER A . n 
A 1 404 ARG 404 403 403 ARG ARG A . n 
A 1 405 THR 405 404 404 THR THR A . n 
A 1 406 PHE 406 405 405 PHE PHE A . n 
A 1 407 LYS 407 406 406 LYS LYS A . n 
A 1 408 SER 408 407 407 SER SER A . n 
A 1 409 LEU 409 408 408 LEU LEU A . n 
A 1 410 PHE 410 409 409 PHE PHE A . n 
A 1 411 ARG 411 410 410 ARG ARG A . n 
A 1 412 ALA 412 411 411 ALA ALA A . n 
A 1 413 SER 413 412 412 SER SER A . n 
A 1 414 ASP 414 413 413 ASP ASP A . n 
A 1 415 GLU 415 414 414 GLU GLU A . n 
A 1 416 SER 416 415 415 SER SER A . n 
A 1 417 VAL 417 416 416 VAL VAL A . n 
A 1 418 LEU 418 417 417 LEU LEU A . n 
A 1 419 SER 419 418 418 SER SER A . n 
A 1 420 MET 420 419 419 MET MET A . n 
A 1 421 HIS 421 420 420 HIS HIS A . n 
A 1 422 LYS 422 421 421 LYS LYS A . n 
A 1 423 VAL 423 422 422 VAL VAL A . n 
A 1 424 CYS 424 423 423 CYS CYS A . n 
A 1 425 GLU 425 424 424 GLU GLU A . n 
A 1 426 ALA 426 425 425 ALA ALA A . n 
A 1 427 GLY 427 426 426 GLY GLY A . n 
A 1 428 GLY 428 427 427 GLY GLY A . n 
A 1 429 LEU 429 428 428 LEU LEU A . n 
A 1 430 PHE 430 429 429 PHE PHE A . n 
A 1 431 VAL 431 430 430 VAL VAL A . n 
A 1 432 ASN 432 431 431 ASN ASN A . n 
A 1 433 SER 433 432 432 SER SER A . n 
A 1 434 PRO 434 433 433 PRO PRO A . n 
A 1 435 GLU 435 434 434 GLU GLU A . n 
A 1 436 GLU 436 435 435 GLU GLU A . n 
A 1 437 PRO 437 436 436 PRO PRO A . n 
A 1 438 SER 438 437 437 SER SER A . n 
A 1 439 LEU 439 438 438 LEU LEU A . n 
A 1 440 SER 440 439 439 SER SER A . n 
A 1 441 ARG 441 440 440 ARG ARG A . n 
A 1 442 MET 442 441 441 MET MET A . n 
A 1 443 VAL 443 442 442 VAL VAL A . n 
A 1 444 THR 444 443 443 THR THR A . n 
A 1 445 GLU 445 444 444 GLU GLU A . n 
A 1 446 GLU 446 445 445 GLU GLU A . n 
A 1 447 GLU 447 446 446 GLU GLU A . n 
A 1 448 ILE 448 447 447 ILE ILE A . n 
A 1 449 GLN 449 448 448 GLN GLN A . n 
A 1 450 PHE 450 449 449 PHE PHE A . n 
A 1 451 TYR 451 450 450 TYR TYR A . n 
A 1 452 VAL 452 451 451 VAL VAL A . n 
A 1 453 GLN 453 452 452 GLN GLN A . n 
A 1 454 GLN 454 453 453 GLN GLN A . n 
A 1 455 PHE 455 454 454 PHE PHE A . n 
A 1 456 LYS 456 455 455 LYS LYS A . n 
A 1 457 LYS 457 456 456 LYS LYS A . n 
A 1 458 SER 458 457 457 SER SER A . n 
A 1 459 GLY 459 458 458 GLY GLY A . n 
A 1 460 PHE 460 459 459 PHE PHE A . n 
A 1 461 ARG 461 460 460 ARG ARG A . n 
A 1 462 GLY 462 461 461 GLY GLY A . n 
A 1 463 PRO 463 462 462 PRO PRO A . n 
A 1 464 LEU 464 463 463 LEU LEU A . n 
A 1 465 ASN 465 464 464 ASN ASN A . n 
A 1 466 TRP 466 465 465 TRP TRP A . n 
A 1 467 TYR 467 466 466 TYR TYR A . n 
A 1 468 ARG 468 467 467 ARG ARG A . n 
A 1 469 ASN 469 468 468 ASN ASN A . n 
A 1 470 MET 470 469 469 MET MET A . n 
A 1 471 GLU 471 470 470 GLU GLU A . n 
A 1 472 ARG 472 471 471 ARG ARG A . n 
A 1 473 ASN 473 472 472 ASN ASN A . n 
A 1 474 TRP 474 473 473 TRP TRP A . n 
A 1 475 LYS 475 474 474 LYS LYS A . n 
A 1 476 TRP 476 475 475 TRP TRP A . n 
A 1 477 ALA 477 476 476 ALA ALA A . n 
A 1 478 CYS 478 477 477 CYS CYS A . n 
A 1 479 LYS 479 478 478 LYS LYS A . n 
A 1 480 SER 480 479 479 SER SER A . n 
A 1 481 LEU 481 480 480 LEU LEU A . n 
A 1 482 GLY 482 481 481 GLY GLY A . n 
A 1 483 ARG 483 482 482 ARG ARG A . n 
A 1 484 LYS 484 483 483 LYS LYS A . n 
A 1 485 ILE 485 484 484 ILE ILE A . n 
A 1 486 LEU 486 485 485 LEU LEU A . n 
A 1 487 ILE 487 486 486 ILE ILE A . n 
A 1 488 PRO 488 487 487 PRO PRO A . n 
A 1 489 ALA 489 488 488 ALA ALA A . n 
A 1 490 LEU 490 489 489 LEU LEU A . n 
A 1 491 MET 491 490 490 MET MET A . n 
A 1 492 VAL 492 491 491 VAL VAL A . n 
A 1 493 THR 493 492 492 THR THR A . n 
A 1 494 ALA 494 493 493 ALA ALA A . n 
A 1 495 GLU 495 494 494 GLU GLU A . n 
A 1 496 LYS 496 495 495 LYS LYS A . n 
A 1 497 ASP 497 496 496 ASP ASP A . n 
A 1 498 PHE 498 497 497 PHE PHE A . n 
A 1 499 VAL 499 498 498 VAL VAL A . n 
A 1 500 LEU 500 499 499 LEU LEU A . n 
A 1 501 VAL 501 500 500 VAL VAL A . n 
A 1 502 PRO 502 501 501 PRO PRO A . n 
A 1 503 GLN 503 502 502 GLN GLN A . n 
A 1 504 MET 504 503 503 MET MET A . n 
A 1 505 SER 505 504 504 SER SER A . n 
A 1 506 GLN 506 505 505 GLN GLN A . n 
A 1 507 HIS 507 506 506 HIS HIS A . n 
A 1 508 MET 508 507 507 MET MET A . n 
A 1 509 GLU 509 508 508 GLU GLU A . n 
A 1 510 ASP 510 509 509 ASP ASP A . n 
A 1 511 TRP 511 510 510 TRP TRP A . n 
A 1 512 ILE 512 511 511 ILE ILE A . n 
A 1 513 PRO 513 512 512 PRO PRO A . n 
A 1 514 HIS 514 513 513 HIS HIS A . n 
A 1 515 LEU 515 514 514 LEU LEU A . n 
A 1 516 LYS 516 515 515 LYS LYS A . n 
A 1 517 ARG 517 516 516 ARG ARG A . n 
A 1 518 GLY 518 517 517 GLY GLY A . n 
A 1 519 HIS 519 518 518 HIS HIS A . n 
A 1 520 ILE 520 519 519 ILE ILE A . n 
A 1 521 GLU 521 520 520 GLU GLU A . n 
A 1 522 ASP 522 521 521 ASP ASP A . n 
A 1 523 CYS 523 522 522 CYS CYS A . n 
A 1 524 GLY 524 523 523 GLY GLY A . n 
A 1 525 HIS 525 524 524 HIS HIS A . n 
A 1 526 TRP 526 525 525 TRP TRP A . n 
A 1 527 THR 527 526 526 THR THR A . n 
A 1 528 GLN 528 527 527 GLN GLN A . n 
A 1 529 MET 529 528 528 MET MET A . n 
A 1 530 ASP 530 529 529 ASP ASP A . n 
A 1 531 LYS 531 530 530 LYS LYS A . n 
A 1 532 PRO 532 531 531 PRO PRO A . n 
A 1 533 THR 533 532 532 THR THR A . n 
A 1 534 GLU 534 533 533 GLU GLU A . n 
A 1 535 VAL 535 534 534 VAL VAL A . n 
A 1 536 ASN 536 535 535 ASN ASN A . n 
A 1 537 GLN 537 536 536 GLN GLN A . n 
A 1 538 ILE 538 537 537 ILE ILE A . n 
A 1 539 LEU 539 538 538 LEU LEU A . n 
A 1 540 ILE 540 539 539 ILE ILE A . n 
A 1 541 LYS 541 540 540 LYS LYS A . n 
A 1 542 TRP 542 541 541 TRP TRP A . n 
A 1 543 LEU 543 542 542 LEU LEU A . n 
A 1 544 ASP 544 543 543 ASP ASP A . n 
A 1 545 SER 545 544 544 SER SER A . n 
A 1 546 ASP 546 545 545 ASP ASP A . n 
A 1 547 ALA 547 546 546 ALA ALA A . n 
A 1 548 ARG 548 547 547 ARG ARG A . n 
A 1 549 ASN 549 548 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 GOL 1   601  601 GOL GOL A . 
C 2 GOL 1   602  602 GOL GOL A . 
D 2 GOL 1   603  603 GOL GOL A . 
E 3 SO4 1   604  1   SO4 SO4 A . 
F 4 NA  1   605  2   NA  NA  A . 
G 5 HOH 1   701  431 HOH HOH A . 
G 5 HOH 2   702  484 HOH HOH A . 
G 5 HOH 3   703  610 HOH HOH A . 
G 5 HOH 4   704  589 HOH HOH A . 
G 5 HOH 5   705  325 HOH HOH A . 
G 5 HOH 6   706  418 HOH HOH A . 
G 5 HOH 7   707  320 HOH HOH A . 
G 5 HOH 8   708  285 HOH HOH A . 
G 5 HOH 9   709  221 HOH HOH A . 
G 5 HOH 10  710  283 HOH HOH A . 
G 5 HOH 11  711  252 HOH HOH A . 
G 5 HOH 12  712  567 HOH HOH A . 
G 5 HOH 13  713  488 HOH HOH A . 
G 5 HOH 14  714  312 HOH HOH A . 
G 5 HOH 15  715  173 HOH HOH A . 
G 5 HOH 16  716  501 HOH HOH A . 
G 5 HOH 17  717  678 HOH HOH A . 
G 5 HOH 18  718  110 HOH HOH A . 
G 5 HOH 19  719  70  HOH HOH A . 
G 5 HOH 20  720  521 HOH HOH A . 
G 5 HOH 21  721  587 HOH HOH A . 
G 5 HOH 22  722  360 HOH HOH A . 
G 5 HOH 23  723  650 HOH HOH A . 
G 5 HOH 24  724  550 HOH HOH A . 
G 5 HOH 25  725  31  HOH HOH A . 
G 5 HOH 26  726  17  HOH HOH A . 
G 5 HOH 27  727  207 HOH HOH A . 
G 5 HOH 28  728  439 HOH HOH A . 
G 5 HOH 29  729  460 HOH HOH A . 
G 5 HOH 30  730  198 HOH HOH A . 
G 5 HOH 31  731  8   HOH HOH A . 
G 5 HOH 32  732  94  HOH HOH A . 
G 5 HOH 33  733  126 HOH HOH A . 
G 5 HOH 34  734  89  HOH HOH A . 
G 5 HOH 35  735  113 HOH HOH A . 
G 5 HOH 36  736  515 HOH HOH A . 
G 5 HOH 37  737  680 HOH HOH A . 
G 5 HOH 38  738  338 HOH HOH A . 
G 5 HOH 39  739  306 HOH HOH A . 
G 5 HOH 40  740  29  HOH HOH A . 
G 5 HOH 41  741  18  HOH HOH A . 
G 5 HOH 42  742  174 HOH HOH A . 
G 5 HOH 43  743  140 HOH HOH A . 
G 5 HOH 44  744  143 HOH HOH A . 
G 5 HOH 45  745  609 HOH HOH A . 
G 5 HOH 46  746  96  HOH HOH A . 
G 5 HOH 47  747  494 HOH HOH A . 
G 5 HOH 48  748  213 HOH HOH A . 
G 5 HOH 49  749  440 HOH HOH A . 
G 5 HOH 50  750  265 HOH HOH A . 
G 5 HOH 51  751  14  HOH HOH A . 
G 5 HOH 52  752  183 HOH HOH A . 
G 5 HOH 53  753  677 HOH HOH A . 
G 5 HOH 54  754  184 HOH HOH A . 
G 5 HOH 55  755  227 HOH HOH A . 
G 5 HOH 56  756  57  HOH HOH A . 
G 5 HOH 57  757  108 HOH HOH A . 
G 5 HOH 58  758  61  HOH HOH A . 
G 5 HOH 59  759  129 HOH HOH A . 
G 5 HOH 60  760  168 HOH HOH A . 
G 5 HOH 61  761  573 HOH HOH A . 
G 5 HOH 62  762  28  HOH HOH A . 
G 5 HOH 63  763  228 HOH HOH A . 
G 5 HOH 64  764  310 HOH HOH A . 
G 5 HOH 65  765  177 HOH HOH A . 
G 5 HOH 66  766  166 HOH HOH A . 
G 5 HOH 67  767  117 HOH HOH A . 
G 5 HOH 68  768  92  HOH HOH A . 
G 5 HOH 69  769  599 HOH HOH A . 
G 5 HOH 70  770  255 HOH HOH A . 
G 5 HOH 71  771  549 HOH HOH A . 
G 5 HOH 72  772  575 HOH HOH A . 
G 5 HOH 73  773  374 HOH HOH A . 
G 5 HOH 74  774  231 HOH HOH A . 
G 5 HOH 75  775  33  HOH HOH A . 
G 5 HOH 76  776  72  HOH HOH A . 
G 5 HOH 77  777  405 HOH HOH A . 
G 5 HOH 78  778  127 HOH HOH A . 
G 5 HOH 79  779  317 HOH HOH A . 
G 5 HOH 80  780  417 HOH HOH A . 
G 5 HOH 81  781  305 HOH HOH A . 
G 5 HOH 82  782  21  HOH HOH A . 
G 5 HOH 83  783  75  HOH HOH A . 
G 5 HOH 84  784  357 HOH HOH A . 
G 5 HOH 85  785  58  HOH HOH A . 
G 5 HOH 86  786  112 HOH HOH A . 
G 5 HOH 87  787  391 HOH HOH A . 
G 5 HOH 88  788  289 HOH HOH A . 
G 5 HOH 89  789  30  HOH HOH A . 
G 5 HOH 90  790  506 HOH HOH A . 
G 5 HOH 91  791  39  HOH HOH A . 
G 5 HOH 92  792  151 HOH HOH A . 
G 5 HOH 93  793  493 HOH HOH A . 
G 5 HOH 94  794  115 HOH HOH A . 
G 5 HOH 95  795  577 HOH HOH A . 
G 5 HOH 96  796  59  HOH HOH A . 
G 5 HOH 97  797  6   HOH HOH A . 
G 5 HOH 98  798  490 HOH HOH A . 
G 5 HOH 99  799  533 HOH HOH A . 
G 5 HOH 100 800  55  HOH HOH A . 
G 5 HOH 101 801  249 HOH HOH A . 
G 5 HOH 102 802  323 HOH HOH A . 
G 5 HOH 103 803  202 HOH HOH A . 
G 5 HOH 104 804  4   HOH HOH A . 
G 5 HOH 105 805  303 HOH HOH A . 
G 5 HOH 106 806  509 HOH HOH A . 
G 5 HOH 107 807  47  HOH HOH A . 
G 5 HOH 108 808  605 HOH HOH A . 
G 5 HOH 109 809  334 HOH HOH A . 
G 5 HOH 110 810  248 HOH HOH A . 
G 5 HOH 111 811  216 HOH HOH A . 
G 5 HOH 112 812  435 HOH HOH A . 
G 5 HOH 113 813  503 HOH HOH A . 
G 5 HOH 114 814  421 HOH HOH A . 
G 5 HOH 115 815  24  HOH HOH A . 
G 5 HOH 116 816  524 HOH HOH A . 
G 5 HOH 117 817  344 HOH HOH A . 
G 5 HOH 118 818  281 HOH HOH A . 
G 5 HOH 119 819  543 HOH HOH A . 
G 5 HOH 120 820  413 HOH HOH A . 
G 5 HOH 121 821  124 HOH HOH A . 
G 5 HOH 122 822  455 HOH HOH A . 
G 5 HOH 123 823  349 HOH HOH A . 
G 5 HOH 124 824  356 HOH HOH A . 
G 5 HOH 125 825  449 HOH HOH A . 
G 5 HOH 126 826  273 HOH HOH A . 
G 5 HOH 127 827  130 HOH HOH A . 
G 5 HOH 128 828  150 HOH HOH A . 
G 5 HOH 129 829  469 HOH HOH A . 
G 5 HOH 130 830  26  HOH HOH A . 
G 5 HOH 131 831  2   HOH HOH A . 
G 5 HOH 132 832  13  HOH HOH A . 
G 5 HOH 133 833  51  HOH HOH A . 
G 5 HOH 134 834  214 HOH HOH A . 
G 5 HOH 135 835  19  HOH HOH A . 
G 5 HOH 136 836  438 HOH HOH A . 
G 5 HOH 137 837  16  HOH HOH A . 
G 5 HOH 138 838  22  HOH HOH A . 
G 5 HOH 139 839  612 HOH HOH A . 
G 5 HOH 140 840  359 HOH HOH A . 
G 5 HOH 141 841  234 HOH HOH A . 
G 5 HOH 142 842  37  HOH HOH A . 
G 5 HOH 143 843  1   HOH HOH A . 
G 5 HOH 144 844  454 HOH HOH A . 
G 5 HOH 145 845  157 HOH HOH A . 
G 5 HOH 146 846  3   HOH HOH A . 
G 5 HOH 147 847  525 HOH HOH A . 
G 5 HOH 148 848  146 HOH HOH A . 
G 5 HOH 149 849  353 HOH HOH A . 
G 5 HOH 150 850  541 HOH HOH A . 
G 5 HOH 151 851  83  HOH HOH A . 
G 5 HOH 152 852  307 HOH HOH A . 
G 5 HOH 153 853  479 HOH HOH A . 
G 5 HOH 154 854  275 HOH HOH A . 
G 5 HOH 155 855  152 HOH HOH A . 
G 5 HOH 156 856  536 HOH HOH A . 
G 5 HOH 157 857  62  HOH HOH A . 
G 5 HOH 158 858  79  HOH HOH A . 
G 5 HOH 159 859  90  HOH HOH A . 
G 5 HOH 160 860  254 HOH HOH A . 
G 5 HOH 161 861  104 HOH HOH A . 
G 5 HOH 162 862  102 HOH HOH A . 
G 5 HOH 163 863  64  HOH HOH A . 
G 5 HOH 164 864  106 HOH HOH A . 
G 5 HOH 165 865  155 HOH HOH A . 
G 5 HOH 166 866  604 HOH HOH A . 
G 5 HOH 167 867  9   HOH HOH A . 
G 5 HOH 168 868  99  HOH HOH A . 
G 5 HOH 169 869  114 HOH HOH A . 
G 5 HOH 170 870  210 HOH HOH A . 
G 5 HOH 171 871  523 HOH HOH A . 
G 5 HOH 172 872  123 HOH HOH A . 
G 5 HOH 173 873  67  HOH HOH A . 
G 5 HOH 174 874  80  HOH HOH A . 
G 5 HOH 175 875  165 HOH HOH A . 
G 5 HOH 176 876  60  HOH HOH A . 
G 5 HOH 177 877  5   HOH HOH A . 
G 5 HOH 178 878  240 HOH HOH A . 
G 5 HOH 179 879  396 HOH HOH A . 
G 5 HOH 180 880  606 HOH HOH A . 
G 5 HOH 181 881  15  HOH HOH A . 
G 5 HOH 182 882  295 HOH HOH A . 
G 5 HOH 183 883  226 HOH HOH A . 
G 5 HOH 184 884  296 HOH HOH A . 
G 5 HOH 185 885  111 HOH HOH A . 
G 5 HOH 186 886  416 HOH HOH A . 
G 5 HOH 187 887  225 HOH HOH A . 
G 5 HOH 188 888  142 HOH HOH A . 
G 5 HOH 189 889  538 HOH HOH A . 
G 5 HOH 190 890  73  HOH HOH A . 
G 5 HOH 191 891  41  HOH HOH A . 
G 5 HOH 192 892  458 HOH HOH A . 
G 5 HOH 193 893  451 HOH HOH A . 
G 5 HOH 194 894  415 HOH HOH A . 
G 5 HOH 195 895  109 HOH HOH A . 
G 5 HOH 196 896  379 HOH HOH A . 
G 5 HOH 197 897  43  HOH HOH A . 
G 5 HOH 198 898  27  HOH HOH A . 
G 5 HOH 199 899  363 HOH HOH A . 
G 5 HOH 200 900  101 HOH HOH A . 
G 5 HOH 201 901  328 HOH HOH A . 
G 5 HOH 202 902  137 HOH HOH A . 
G 5 HOH 203 903  282 HOH HOH A . 
G 5 HOH 204 904  105 HOH HOH A . 
G 5 HOH 205 905  154 HOH HOH A . 
G 5 HOH 206 906  365 HOH HOH A . 
G 5 HOH 207 907  499 HOH HOH A . 
G 5 HOH 208 908  519 HOH HOH A . 
G 5 HOH 209 909  34  HOH HOH A . 
G 5 HOH 210 910  54  HOH HOH A . 
G 5 HOH 211 911  199 HOH HOH A . 
G 5 HOH 212 912  194 HOH HOH A . 
G 5 HOH 213 913  402 HOH HOH A . 
G 5 HOH 214 914  683 HOH HOH A . 
G 5 HOH 215 915  222 HOH HOH A . 
G 5 HOH 216 916  453 HOH HOH A . 
G 5 HOH 217 917  427 HOH HOH A . 
G 5 HOH 218 918  167 HOH HOH A . 
G 5 HOH 219 919  65  HOH HOH A . 
G 5 HOH 220 920  596 HOH HOH A . 
G 5 HOH 221 921  7   HOH HOH A . 
G 5 HOH 222 922  63  HOH HOH A . 
G 5 HOH 223 923  441 HOH HOH A . 
G 5 HOH 224 924  156 HOH HOH A . 
G 5 HOH 225 925  512 HOH HOH A . 
G 5 HOH 226 926  78  HOH HOH A . 
G 5 HOH 227 927  358 HOH HOH A . 
G 5 HOH 228 928  230 HOH HOH A . 
G 5 HOH 229 929  693 HOH HOH A . 
G 5 HOH 230 930  486 HOH HOH A . 
G 5 HOH 231 931  251 HOH HOH A . 
G 5 HOH 232 932  170 HOH HOH A . 
G 5 HOH 233 933  35  HOH HOH A . 
G 5 HOH 234 934  188 HOH HOH A . 
G 5 HOH 235 935  212 HOH HOH A . 
G 5 HOH 236 936  219 HOH HOH A . 
G 5 HOH 237 937  332 HOH HOH A . 
G 5 HOH 238 938  203 HOH HOH A . 
G 5 HOH 239 939  424 HOH HOH A . 
G 5 HOH 240 940  87  HOH HOH A . 
G 5 HOH 241 941  38  HOH HOH A . 
G 5 HOH 242 942  489 HOH HOH A . 
G 5 HOH 243 943  420 HOH HOH A . 
G 5 HOH 244 944  292 HOH HOH A . 
G 5 HOH 245 945  160 HOH HOH A . 
G 5 HOH 246 946  175 HOH HOH A . 
G 5 HOH 247 947  135 HOH HOH A . 
G 5 HOH 248 948  50  HOH HOH A . 
G 5 HOH 249 949  11  HOH HOH A . 
G 5 HOH 250 950  534 HOH HOH A . 
G 5 HOH 251 951  516 HOH HOH A . 
G 5 HOH 252 952  238 HOH HOH A . 
G 5 HOH 253 953  46  HOH HOH A . 
G 5 HOH 254 954  371 HOH HOH A . 
G 5 HOH 255 955  414 HOH HOH A . 
G 5 HOH 256 956  49  HOH HOH A . 
G 5 HOH 257 957  293 HOH HOH A . 
G 5 HOH 258 958  444 HOH HOH A . 
G 5 HOH 259 959  428 HOH HOH A . 
G 5 HOH 260 960  407 HOH HOH A . 
G 5 HOH 261 961  147 HOH HOH A . 
G 5 HOH 262 962  467 HOH HOH A . 
G 5 HOH 263 963  375 HOH HOH A . 
G 5 HOH 264 964  697 HOH HOH A . 
G 5 HOH 265 965  508 HOH HOH A . 
G 5 HOH 266 966  209 HOH HOH A . 
G 5 HOH 267 967  366 HOH HOH A . 
G 5 HOH 268 968  434 HOH HOH A . 
G 5 HOH 269 969  42  HOH HOH A . 
G 5 HOH 270 970  287 HOH HOH A . 
G 5 HOH 271 971  430 HOH HOH A . 
G 5 HOH 272 972  23  HOH HOH A . 
G 5 HOH 273 973  664 HOH HOH A . 
G 5 HOH 274 974  45  HOH HOH A . 
G 5 HOH 275 975  485 HOH HOH A . 
G 5 HOH 276 976  522 HOH HOH A . 
G 5 HOH 277 977  463 HOH HOH A . 
G 5 HOH 278 978  309 HOH HOH A . 
G 5 HOH 279 979  504 HOH HOH A . 
G 5 HOH 280 980  685 HOH HOH A . 
G 5 HOH 281 981  452 HOH HOH A . 
G 5 HOH 282 982  695 HOH HOH A . 
G 5 HOH 283 983  496 HOH HOH A . 
G 5 HOH 284 984  77  HOH HOH A . 
G 5 HOH 285 985  279 HOH HOH A . 
G 5 HOH 286 986  497 HOH HOH A . 
G 5 HOH 287 987  663 HOH HOH A . 
G 5 HOH 288 988  351 HOH HOH A . 
G 5 HOH 289 989  178 HOH HOH A . 
G 5 HOH 290 990  121 HOH HOH A . 
G 5 HOH 291 991  530 HOH HOH A . 
G 5 HOH 292 992  116 HOH HOH A . 
G 5 HOH 293 993  161 HOH HOH A . 
G 5 HOH 294 994  331 HOH HOH A . 
G 5 HOH 295 995  445 HOH HOH A . 
G 5 HOH 296 996  12  HOH HOH A . 
G 5 HOH 297 997  220 HOH HOH A . 
G 5 HOH 298 998  313 HOH HOH A . 
G 5 HOH 299 999  394 HOH HOH A . 
G 5 HOH 300 1000 304 HOH HOH A . 
G 5 HOH 301 1001 186 HOH HOH A . 
G 5 HOH 302 1002 369 HOH HOH A . 
G 5 HOH 303 1003 410 HOH HOH A . 
G 5 HOH 304 1004 144 HOH HOH A . 
G 5 HOH 305 1005 364 HOH HOH A . 
G 5 HOH 306 1006 436 HOH HOH A . 
G 5 HOH 307 1007 32  HOH HOH A . 
G 5 HOH 308 1008 235 HOH HOH A . 
G 5 HOH 309 1009 639 HOH HOH A . 
G 5 HOH 310 1010 153 HOH HOH A . 
G 5 HOH 311 1011 20  HOH HOH A . 
G 5 HOH 312 1012 361 HOH HOH A . 
G 5 HOH 313 1013 611 HOH HOH A . 
G 5 HOH 314 1014 668 HOH HOH A . 
G 5 HOH 315 1015 447 HOH HOH A . 
G 5 HOH 316 1016 425 HOH HOH A . 
G 5 HOH 317 1017 125 HOH HOH A . 
G 5 HOH 318 1018 330 HOH HOH A . 
G 5 HOH 319 1019 426 HOH HOH A . 
G 5 HOH 320 1020 69  HOH HOH A . 
G 5 HOH 321 1021 280 HOH HOH A . 
G 5 HOH 322 1022 456 HOH HOH A . 
G 5 HOH 323 1023 298 HOH HOH A . 
G 5 HOH 324 1024 191 HOH HOH A . 
G 5 HOH 325 1025 40  HOH HOH A . 
G 5 HOH 326 1026 171 HOH HOH A . 
G 5 HOH 327 1027 158 HOH HOH A . 
G 5 HOH 328 1028 131 HOH HOH A . 
G 5 HOH 329 1029 404 HOH HOH A . 
G 5 HOH 330 1030 432 HOH HOH A . 
G 5 HOH 331 1031 667 HOH HOH A . 
G 5 HOH 332 1032 465 HOH HOH A . 
G 5 HOH 333 1033 423 HOH HOH A . 
G 5 HOH 334 1034 529 HOH HOH A . 
G 5 HOH 335 1035 505 HOH HOH A . 
G 5 HOH 336 1036 466 HOH HOH A . 
G 5 HOH 337 1037 532 HOH HOH A . 
G 5 HOH 338 1038 502 HOH HOH A . 
G 5 HOH 339 1039 354 HOH HOH A . 
G 5 HOH 340 1040 206 HOH HOH A . 
G 5 HOH 341 1041 36  HOH HOH A . 
G 5 HOH 342 1042 336 HOH HOH A . 
G 5 HOH 343 1043 197 HOH HOH A . 
G 5 HOH 344 1044 44  HOH HOH A . 
G 5 HOH 345 1045 138 HOH HOH A . 
G 5 HOH 346 1046 84  HOH HOH A . 
G 5 HOH 347 1047 393 HOH HOH A . 
G 5 HOH 348 1048 544 HOH HOH A . 
G 5 HOH 349 1049 655 HOH HOH A . 
G 5 HOH 350 1050 56  HOH HOH A . 
G 5 HOH 351 1051 443 HOH HOH A . 
G 5 HOH 352 1052 615 HOH HOH A . 
G 5 HOH 353 1053 547 HOH HOH A . 
G 5 HOH 354 1054 76  HOH HOH A . 
G 5 HOH 355 1055 100 HOH HOH A . 
G 5 HOH 356 1056 48  HOH HOH A . 
G 5 HOH 357 1057 370 HOH HOH A . 
G 5 HOH 358 1058 684 HOH HOH A . 
G 5 HOH 359 1059 169 HOH HOH A . 
G 5 HOH 360 1060 53  HOH HOH A . 
G 5 HOH 361 1061 616 HOH HOH A . 
G 5 HOH 362 1062 539 HOH HOH A . 
G 5 HOH 363 1063 162 HOH HOH A . 
G 5 HOH 364 1064 340 HOH HOH A . 
G 5 HOH 365 1065 583 HOH HOH A . 
G 5 HOH 366 1066 462 HOH HOH A . 
G 5 HOH 367 1067 500 HOH HOH A . 
G 5 HOH 368 1068 326 HOH HOH A . 
G 5 HOH 369 1069 694 HOH HOH A . 
G 5 HOH 370 1070 66  HOH HOH A . 
G 5 HOH 371 1071 139 HOH HOH A . 
G 5 HOH 372 1072 419 HOH HOH A . 
G 5 HOH 373 1073 471 HOH HOH A . 
G 5 HOH 374 1074 517 HOH HOH A . 
G 5 HOH 375 1075 52  HOH HOH A . 
G 5 HOH 376 1076 367 HOH HOH A . 
G 5 HOH 377 1077 318 HOH HOH A . 
G 5 HOH 378 1078 302 HOH HOH A . 
G 5 HOH 379 1079 480 HOH HOH A . 
G 5 HOH 380 1080 429 HOH HOH A . 
G 5 HOH 381 1081 71  HOH HOH A . 
G 5 HOH 382 1082 91  HOH HOH A . 
G 5 HOH 383 1083 422 HOH HOH A . 
G 5 HOH 384 1084 495 HOH HOH A . 
G 5 HOH 385 1085 264 HOH HOH A . 
G 5 HOH 386 1086 133 HOH HOH A . 
G 5 HOH 387 1087 276 HOH HOH A . 
G 5 HOH 388 1088 10  HOH HOH A . 
G 5 HOH 389 1089 164 HOH HOH A . 
G 5 HOH 390 1090 673 HOH HOH A . 
G 5 HOH 391 1091 482 HOH HOH A . 
G 5 HOH 392 1092 470 HOH HOH A . 
G 5 HOH 393 1093 107 HOH HOH A . 
G 5 HOH 394 1094 545 HOH HOH A . 
G 5 HOH 395 1095 531 HOH HOH A . 
G 5 HOH 396 1096 179 HOH HOH A . 
G 5 HOH 397 1097 397 HOH HOH A . 
G 5 HOH 398 1098 457 HOH HOH A . 
G 5 HOH 399 1099 498 HOH HOH A . 
G 5 HOH 400 1100 103 HOH HOH A . 
G 5 HOH 401 1101 607 HOH HOH A . 
G 5 HOH 402 1102 187 HOH HOH A . 
G 5 HOH 403 1103 159 HOH HOH A . 
G 5 HOH 404 1104 481 HOH HOH A . 
G 5 HOH 405 1105 185 HOH HOH A . 
G 5 HOH 406 1106 468 HOH HOH A . 
G 5 HOH 407 1107 450 HOH HOH A . 
G 5 HOH 408 1108 662 HOH HOH A . 
G 5 HOH 409 1109 535 HOH HOH A . 
G 5 HOH 410 1110 437 HOH HOH A . 
G 5 HOH 411 1111 148 HOH HOH A . 
G 5 HOH 412 1112 145 HOH HOH A . 
G 5 HOH 413 1113 475 HOH HOH A . 
G 5 HOH 414 1114 526 HOH HOH A . 
G 5 HOH 415 1115 492 HOH HOH A . 
G 5 HOH 416 1116 474 HOH HOH A . 
G 5 HOH 417 1117 132 HOH HOH A . 
G 5 HOH 418 1118 398 HOH HOH A . 
G 5 HOH 419 1119 511 HOH HOH A . 
G 5 HOH 420 1120 591 HOH HOH A . 
G 5 HOH 421 1121 284 HOH HOH A . 
G 5 HOH 422 1122 382 HOH HOH A . 
G 5 HOH 423 1123 267 HOH HOH A . 
G 5 HOH 424 1124 300 HOH HOH A . 
G 5 HOH 425 1125 387 HOH HOH A . 
G 5 HOH 426 1126 555 HOH HOH A . 
G 5 HOH 427 1127 629 HOH HOH A . 
G 5 HOH 428 1128 669 HOH HOH A . 
G 5 HOH 429 1129 291 HOH HOH A . 
G 5 HOH 430 1130 163 HOH HOH A . 
G 5 HOH 431 1131 411 HOH HOH A . 
G 5 HOH 432 1132 578 HOH HOH A . 
G 5 HOH 433 1133 580 HOH HOH A . 
G 5 HOH 434 1134 518 HOH HOH A . 
G 5 HOH 435 1135 644 HOH HOH A . 
G 5 HOH 436 1136 483 HOH HOH A . 
G 5 HOH 437 1137 327 HOH HOH A . 
G 5 HOH 438 1138 247 HOH HOH A . 
G 5 HOH 439 1139 384 HOH HOH A . 
G 5 HOH 440 1140 527 HOH HOH A . 
G 5 HOH 441 1141 556 HOH HOH A . 
G 5 HOH 442 1142 514 HOH HOH A . 
G 5 HOH 443 1143 520 HOH HOH A . 
G 5 HOH 444 1144 149 HOH HOH A . 
G 5 HOH 445 1145 507 HOH HOH A . 
G 5 HOH 446 1146 205 HOH HOH A . 
G 5 HOH 447 1147 513 HOH HOH A . 
G 5 HOH 448 1148 316 HOH HOH A . 
G 5 HOH 449 1149 619 HOH HOH A . 
G 5 HOH 450 1150 645 HOH HOH A . 
G 5 HOH 451 1151 236 HOH HOH A . 
G 5 HOH 452 1152 239 HOH HOH A . 
G 5 HOH 453 1153 687 HOH HOH A . 
G 5 HOH 454 1154 542 HOH HOH A . 
G 5 HOH 455 1155 554 HOH HOH A . 
G 5 HOH 456 1156 624 HOH HOH A . 
G 5 HOH 457 1157 491 HOH HOH A . 
G 5 HOH 458 1158 566 HOH HOH A . 
G 5 HOH 459 1159 176 HOH HOH A . 
G 5 HOH 460 1160 528 HOH HOH A . 
G 5 HOH 461 1161 585 HOH HOH A . 
G 5 HOH 462 1162 595 HOH HOH A . 
G 5 HOH 463 1163 271 HOH HOH A . 
G 5 HOH 464 1164 196 HOH HOH A . 
G 5 HOH 465 1165 346 HOH HOH A . 
G 5 HOH 466 1166 352 HOH HOH A . 
G 5 HOH 467 1167 661 HOH HOH A . 
G 5 HOH 468 1168 88  HOH HOH A . 
G 5 HOH 469 1169 93  HOH HOH A . 
G 5 HOH 470 1170 692 HOH HOH A . 
G 5 HOH 471 1171 571 HOH HOH A . 
G 5 HOH 472 1172 321 HOH HOH A . 
G 5 HOH 473 1173 682 HOH HOH A . 
G 5 HOH 474 1174 627 HOH HOH A . 
G 5 HOH 475 1175 621 HOH HOH A . 
G 5 HOH 476 1176 660 HOH HOH A . 
G 5 HOH 477 1177 250 HOH HOH A . 
G 5 HOH 478 1178 229 HOH HOH A . 
G 5 HOH 479 1179 208 HOH HOH A . 
G 5 HOH 480 1180 476 HOH HOH A . 
G 5 HOH 481 1181 510 HOH HOH A . 
G 5 HOH 482 1182 355 HOH HOH A . 
G 5 HOH 483 1183 565 HOH HOH A . 
G 5 HOH 484 1184 654 HOH HOH A . 
G 5 HOH 485 1185 122 HOH HOH A . 
G 5 HOH 486 1186 546 HOH HOH A . 
G 5 HOH 487 1187 211 HOH HOH A . 
G 5 HOH 488 1188 652 HOH HOH A . 
G 5 HOH 489 1189 68  HOH HOH A . 
G 5 HOH 490 1190 665 HOH HOH A . 
G 5 HOH 491 1191 620 HOH HOH A . 
G 5 HOH 492 1192 195 HOH HOH A . 
G 5 HOH 493 1193 217 HOH HOH A . 
G 5 HOH 494 1194 392 HOH HOH A . 
G 5 HOH 495 1195 658 HOH HOH A . 
G 5 HOH 496 1196 190 HOH HOH A . 
G 5 HOH 497 1197 119 HOH HOH A . 
G 5 HOH 498 1198 388 HOH HOH A . 
G 5 HOH 499 1199 383 HOH HOH A . 
G 5 HOH 500 1200 649 HOH HOH A . 
G 5 HOH 501 1201 553 HOH HOH A . 
G 5 HOH 502 1202 477 HOH HOH A . 
G 5 HOH 503 1203 487 HOH HOH A . 
G 5 HOH 504 1204 562 HOH HOH A . 
G 5 HOH 505 1205 172 HOH HOH A . 
G 5 HOH 506 1206 647 HOH HOH A . 
G 5 HOH 507 1207 601 HOH HOH A . 
G 5 HOH 508 1208 233 HOH HOH A . 
G 5 HOH 509 1209 390 HOH HOH A . 
G 5 HOH 510 1210 337 HOH HOH A . 
G 5 HOH 511 1211 641 HOH HOH A . 
G 5 HOH 512 1212 632 HOH HOH A . 
G 5 HOH 513 1213 576 HOH HOH A . 
G 5 HOH 514 1214 626 HOH HOH A . 
G 5 HOH 515 1215 81  HOH HOH A . 
G 5 HOH 516 1216 681 HOH HOH A . 
G 5 HOH 517 1217 689 HOH HOH A . 
G 5 HOH 518 1218 218 HOH HOH A . 
G 5 HOH 519 1219 613 HOH HOH A . 
G 5 HOH 520 1220 362 HOH HOH A . 
G 5 HOH 521 1221 646 HOH HOH A . 
G 5 HOH 522 1222 347 HOH HOH A . 
G 5 HOH 523 1223 653 HOH HOH A . 
G 5 HOH 524 1224 636 HOH HOH A . 
G 5 HOH 525 1225 564 HOH HOH A . 
G 5 HOH 526 1226 385 HOH HOH A . 
G 5 HOH 527 1227 623 HOH HOH A . 
G 5 HOH 528 1228 588 HOH HOH A . 
G 5 HOH 529 1229 560 HOH HOH A . 
G 5 HOH 530 1230 569 HOH HOH A . 
G 5 HOH 531 1231 386 HOH HOH A . 
G 5 HOH 532 1232 74  HOH HOH A . 
G 5 HOH 533 1233 472 HOH HOH A . 
G 5 HOH 534 1234 232 HOH HOH A . 
G 5 HOH 535 1235 180 HOH HOH A . 
G 5 HOH 536 1236 286 HOH HOH A . 
G 5 HOH 537 1237 574 HOH HOH A . 
G 5 HOH 538 1238 672 HOH HOH A . 
G 5 HOH 539 1239 572 HOH HOH A . 
G 5 HOH 540 1240 586 HOH HOH A . 
G 5 HOH 541 1241 686 HOH HOH A . 
G 5 HOH 542 1242 540 HOH HOH A . 
G 5 HOH 543 1243 608 HOH HOH A . 
G 5 HOH 544 1244 335 HOH HOH A . 
G 5 HOH 545 1245 671 HOH HOH A . 
G 5 HOH 546 1246 597 HOH HOH A . 
G 5 HOH 547 1247 582 HOH HOH A . 
G 5 HOH 548 1248 603 HOH HOH A . 
G 5 HOH 549 1249 557 HOH HOH A . 
G 5 HOH 550 1250 635 HOH HOH A . 
G 5 HOH 551 1251 98  HOH HOH A . 
G 5 HOH 552 1252 657 HOH HOH A . 
G 5 HOH 553 1253 637 HOH HOH A . 
G 5 HOH 554 1254 656 HOH HOH A . 
G 5 HOH 555 1255 584 HOH HOH A . 
G 5 HOH 556 1256 642 HOH HOH A . 
G 5 HOH 557 1257 478 HOH HOH A . 
G 5 HOH 558 1258 581 HOH HOH A . 
G 5 HOH 559 1259 406 HOH HOH A . 
G 5 HOH 560 1260 329 HOH HOH A . 
G 5 HOH 561 1261 464 HOH HOH A . 
G 5 HOH 562 1262 301 HOH HOH A . 
G 5 HOH 563 1263 643 HOH HOH A . 
G 5 HOH 564 1264 408 HOH HOH A . 
G 5 HOH 565 1265 640 HOH HOH A . 
G 5 HOH 566 1266 579 HOH HOH A . 
G 5 HOH 567 1267 204 HOH HOH A . 
G 5 HOH 568 1268 674 HOH HOH A . 
G 5 HOH 569 1269 696 HOH HOH A . 
G 5 HOH 570 1270 592 HOH HOH A . 
G 5 HOH 571 1271 294 HOH HOH A . 
G 5 HOH 572 1272 288 HOH HOH A . 
G 5 HOH 573 1273 594 HOH HOH A . 
G 5 HOH 574 1274 628 HOH HOH A . 
G 5 HOH 575 1275 570 HOH HOH A . 
G 5 HOH 576 1276 593 HOH HOH A . 
G 5 HOH 577 1277 558 HOH HOH A . 
G 5 HOH 578 1278 552 HOH HOH A . 
G 5 HOH 579 1279 679 HOH HOH A . 
G 5 HOH 580 1280 348 HOH HOH A . 
G 5 HOH 581 1281 563 HOH HOH A . 
G 5 HOH 582 1282 389 HOH HOH A . 
G 5 HOH 583 1283 473 HOH HOH A . 
G 5 HOH 584 1284 290 HOH HOH A . 
G 5 HOH 585 1285 630 HOH HOH A . 
G 5 HOH 586 1286 368 HOH HOH A . 
G 5 HOH 587 1287 224 HOH HOH A . 
G 5 HOH 588 1288 568 HOH HOH A . 
G 5 HOH 589 1289 633 HOH HOH A . 
G 5 HOH 590 1290 600 HOH HOH A . 
G 5 HOH 591 1291 670 HOH HOH A . 
G 5 HOH 592 1292 598 HOH HOH A . 
G 5 HOH 593 1293 602 HOH HOH A . 
G 5 HOH 594 1294 322 HOH HOH A . 
G 5 HOH 595 1295 559 HOH HOH A . 
G 5 HOH 596 1296 590 HOH HOH A . 
G 5 HOH 597 1297 690 HOH HOH A . 
G 5 HOH 598 1298 350 HOH HOH A . 
G 5 HOH 599 1299 548 HOH HOH A . 
G 5 HOH 600 1300 676 HOH HOH A . 
G 5 HOH 601 1301 95  HOH HOH A . 
G 5 HOH 602 1302 648 HOH HOH A . 
G 5 HOH 603 1303 561 HOH HOH A . 
G 5 HOH 604 1304 631 HOH HOH A . 
G 5 HOH 605 1305 409 HOH HOH A . 
G 5 HOH 606 1306 278 HOH HOH A . 
G 5 HOH 607 1307 634 HOH HOH A . 
G 5 HOH 608 1308 339 HOH HOH A . 
G 5 HOH 609 1309 622 HOH HOH A . 
G 5 HOH 610 1310 688 HOH HOH A . 
G 5 HOH 611 1311 691 HOH HOH A . 
G 5 HOH 612 1312 659 HOH HOH A . 
G 5 HOH 613 1313 618 HOH HOH A . 
G 5 HOH 614 1314 698 HOH HOH A . 
G 5 HOH 615 1315 614 HOH HOH A . 
G 5 HOH 616 1316 333 HOH HOH A . 
G 5 HOH 617 1317 675 HOH HOH A . 
G 5 HOH 618 1318 625 HOH HOH A . 
G 5 HOH 619 1319 651 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 73  ? CG  ? A LYS 74  CG  
2  1 Y 1 A LYS 73  ? CD  ? A LYS 74  CD  
3  1 Y 1 A LYS 73  ? CE  ? A LYS 74  CE  
4  1 Y 1 A LYS 73  ? NZ  ? A LYS 74  NZ  
5  1 Y 1 A GLU 76  ? CG  ? A GLU 77  CG  
6  1 Y 1 A GLU 76  ? CD  ? A GLU 77  CD  
7  1 Y 1 A GLU 76  ? OE1 ? A GLU 77  OE1 
8  1 Y 1 A GLU 76  ? OE2 ? A GLU 77  OE2 
9  1 Y 1 A LYS 79  ? CG  ? A LYS 80  CG  
10 1 Y 1 A LYS 79  ? CD  ? A LYS 80  CD  
11 1 Y 1 A LYS 79  ? CE  ? A LYS 80  CE  
12 1 Y 1 A LYS 79  ? NZ  ? A LYS 80  NZ  
13 1 Y 1 A GLU 424 ? CG  ? A GLU 425 CG  
14 1 Y 1 A GLU 424 ? CD  ? A GLU 425 CD  
15 1 Y 1 A GLU 424 ? OE1 ? A GLU 425 OE1 
16 1 Y 1 A GLU 424 ? OE2 ? A GLU 425 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_reference_DOI 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? BUSTER  ? ? ? 2.11.8 ? 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? MOSFLM  ? ? ? .      ? 2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .      ? 3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .      ? 4 
# 
_cell.angle_alpha                  90 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9EXM 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     93.156 
_cell.length_a_esd                 ? 
_cell.length_b                     93.156 
_cell.length_b_esd                 ? 
_cell.length_c                     246.213 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9EXM 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                179 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 65 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9EXM 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.49 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50.54 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '32-38% PEG 3350, 0.1 M LiSO4, 0.1 M Tris pH 8.5.' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2018-06-25 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9686 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I24' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9686 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I24 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9EXM 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.64 
_reflns.d_resolution_low                               80.67 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     70343 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           95.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.102 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.67 
_reflns_shell.d_res_low                                     1.76 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.1 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             527 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          89.9 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  7.51 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.0109 
_refine.aniso_B[1][2]                            0 
_refine.aniso_B[1][3]                            0 
_refine.aniso_B[2][2]                            0.0109 
_refine.aniso_B[2][3]                            0 
_refine.aniso_B[3][3]                            -0.0217 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               35.62 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.962 
_refine.correlation_coeff_Fo_to_Fc_free          0.941 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9EXM 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.64 
_refine.ls_d_res_low                             80.67 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     69335 
_refine.ls_number_reflns_R_free                  3473 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    88.7 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1971 
_refine.ls_R_factor_R_free                       0.2291 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1954 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   0.105 
_refine.pdbx_overall_SU_R_free_Blow_DPI          0.112 
_refine.pdbx_overall_SU_R_Blow_DPI               0.118 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             0.106 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_analyze.entry_id                        9EXM 
_refine_analyze.pdbx_refine_id                  'X-RAY DIFFRACTION' 
_refine_analyze.Luzzati_coordinate_error_free   ? 
_refine_analyze.Luzzati_coordinate_error_obs    0.23 
_refine_analyze.Luzzati_d_res_low_free          ? 
_refine_analyze.Luzzati_d_res_low_obs           ? 
_refine_analyze.Luzzati_sigma_a_free            ? 
_refine_analyze.Luzzati_sigma_a_free_details    ? 
_refine_analyze.Luzzati_sigma_a_obs             ? 
_refine_analyze.Luzzati_sigma_a_obs_details     ? 
_refine_analyze.number_disordered_residues      ? 
_refine_analyze.occupancy_sum_hydrogen          ? 
_refine_analyze.occupancy_sum_non_hydrogen      ? 
_refine_analyze.RG_d_res_high                   ? 
_refine_analyze.RG_d_res_low                    ? 
_refine_analyze.RG_free                         ? 
_refine_analyze.RG_work                         ? 
_refine_analyze.RG_free_work_ratio              ? 
_refine_analyze.pdbx_Luzzati_d_res_high_obs     ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.64 
_refine_hist.d_res_low                        80.67 
_refine_hist.number_atoms_solvent             619 
_refine_hist.number_atoms_total               4950 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4307 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         24 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_Zscore 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.01  ? 4536 ? t_bond_d                  2  ? HARMONIC     
'X-RAY DIFFRACTION' ? 0.98  ? 6159 ? t_angle_deg               2  ? HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 1593 ? t_dihedral_angle_d        2  ? SINUSOIDAL   
'X-RAY DIFFRACTION' ? ?     ? 764  ? t_gen_planes              5  ? HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 4536 ? t_it                      10 ? HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 574  ? t_chiral_improper_torsion 5  ? SEMIHARMONIC 
'X-RAY DIFFRACTION' ? ?     ? 4627 ? t_ideal_dist_contact      4  ? SEMIHARMONIC 
'X-RAY DIFFRACTION' ? 3.81  ? ?    ? t_omega_torsion           ?  ? ?            
'X-RAY DIFFRACTION' ? 15.78 ? ?    ? t_other_torsion           ?  ? ?            
# 
_refine_ls_shell.pdbx_refine_id                      'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                          1.64 
_refine_ls_shell.d_res_low                           1.7 
_refine_ls_shell.number_reflns_all                   ? 
_refine_ls_shell.number_reflns_obs                   1387 
_refine_ls_shell.number_reflns_R_free                79 
_refine_ls_shell.number_reflns_R_work                ? 
_refine_ls_shell.percent_reflns_obs                  17 
_refine_ls_shell.percent_reflns_R_free               ? 
_refine_ls_shell.R_factor_all                        ? 
_refine_ls_shell.R_factor_obs                        0.2967 
_refine_ls_shell.R_factor_R_free_error               ? 
_refine_ls_shell.R_factor_R_work                     0.2967 
_refine_ls_shell.redundancy_reflns_all               ? 
_refine_ls_shell.redundancy_reflns_obs               ? 
_refine_ls_shell.wR_factor_all                       ? 
_refine_ls_shell.wR_factor_obs                       ? 
_refine_ls_shell.wR_factor_R_free                    ? 
_refine_ls_shell.wR_factor_R_work                    ? 
_refine_ls_shell.pdbx_R_complete                     ? 
_refine_ls_shell.correlation_coeff_Fo_to_Fc          ? 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free     ? 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work   ? 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free   ? 
_refine_ls_shell.pdbx_total_number_of_bins_used      ? 
_refine_ls_shell.pdbx_phase_error                    ? 
_refine_ls_shell.pdbx_fsc_work                       ? 
_refine_ls_shell.pdbx_fsc_free                       ? 
_refine_ls_shell.R_factor_R_free                     0.2966 
# 
_struct.entry_id                     9EXM 
_struct.title                        'Cryogenic APO structures of soluble epoxide hydrolase' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9EXM 
_struct_keywords.text            'soluble epoxide hydrolase, sEH, APO, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 4 ? 
G N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    HYES_HUMAN 
_struct_ref.pdbx_db_accession          P34913 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKV
CLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVK
PEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTF
LDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQN
LSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARN
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9EXM 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 2 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 549 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P34913 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  548 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       548 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9EXM 
_struct_ref_seq_dif.mon_id                       GLY 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      1 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P34913 
_struct_ref_seq_dif.db_mon_id                    ? 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          ? 
_struct_ref_seq_dif.details                      'expression tag' 
_struct_ref_seq_dif.pdbx_auth_seq_num            0 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 900   ? 
1 MORE         -24   ? 
1 'SSA (A^2)'  23750 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 19  ? PHE A 21  ? ALA A 18  PHE A 20  5 ? 3  
HELX_P HELX_P2  AA2 GLY A 22  ? LEU A 31  ? GLY A 21  LEU A 30  1 ? 10 
HELX_P HELX_P3  AA3 GLY A 36  ? LYS A 44  ? GLY A 35  LYS A 43  1 ? 9  
HELX_P HELX_P4  AA4 GLY A 45  ? GLU A 48  ? GLY A 44  GLU A 47  5 ? 4  
HELX_P HELX_P5  AA5 GLY A 49  ? LYS A 56  ? GLY A 48  LYS A 55  1 ? 8  
HELX_P HELX_P6  AA6 THR A 60  ? LYS A 80  ? THR A 59  LYS A 79  1 ? 21 
HELX_P HELX_P7  AA7 SER A 88  ? ARG A 100 ? SER A 87  ARG A 99  1 ? 13 
HELX_P HELX_P8  AA8 ASN A 103 ? LYS A 116 ? ASN A 102 LYS A 115 1 ? 14 
HELX_P HELX_P9  AA9 ARG A 134 ? MET A 146 ? ARG A 133 MET A 145 1 ? 13 
HELX_P HELX_P10 AB1 SER A 154 ? GLY A 158 ? SER A 153 GLY A 157 1 ? 5  
HELX_P HELX_P11 AB2 GLU A 163 ? LYS A 175 ? GLU A 162 LYS A 174 1 ? 13 
HELX_P HELX_P12 AB3 SER A 177 ? SER A 179 ? SER A 176 SER A 178 5 ? 3  
HELX_P HELX_P13 AB4 ILE A 187 ? GLY A 198 ? ILE A 186 GLY A 197 1 ? 12 
HELX_P HELX_P14 AB5 ASP A 206 ? GLY A 219 ? ASP A 205 GLY A 218 1 ? 14 
HELX_P HELX_P15 AB6 ASN A 234 ? MET A 238 ? ASN A 233 MET A 237 5 ? 5  
HELX_P HELX_P16 AB7 SER A 271 ? ARG A 276 ? SER A 270 ARG A 275 5 ? 6  
HELX_P HELX_P17 AB8 GLN A 278 ? ALA A 285 ? GLN A 277 ALA A 284 1 ? 8  
HELX_P HELX_P18 AB9 GLU A 305 ? TYR A 309 ? GLU A 304 TYR A 308 5 ? 5  
HELX_P HELX_P19 AC1 CYS A 310 ? GLY A 326 ? CYS A 309 GLY A 325 1 ? 17 
HELX_P HELX_P20 AC2 ASP A 336 ? TYR A 349 ? ASP A 335 TYR A 348 1 ? 14 
HELX_P HELX_P21 AC3 SER A 371 ? ALA A 378 ? SER A 370 ALA A 377 1 ? 8  
HELX_P HELX_P22 AC4 ASN A 379 ? VAL A 381 ? ASN A 378 VAL A 380 5 ? 3  
HELX_P HELX_P23 AC5 PHE A 382 ? PHE A 388 ? PHE A 381 PHE A 387 1 ? 7  
HELX_P HELX_P24 AC6 GLY A 392 ? GLN A 400 ? GLY A 391 GLN A 399 1 ? 9  
HELX_P HELX_P25 AC7 ASN A 401 ? PHE A 410 ? ASN A 400 PHE A 409 1 ? 10 
HELX_P HELX_P26 AC8 LYS A 422 ? GLY A 427 ? LYS A 421 GLY A 426 1 ? 6  
HELX_P HELX_P27 AC9 THR A 444 ? LYS A 457 ? THR A 443 LYS A 456 1 ? 14 
HELX_P HELX_P28 AD1 PHE A 460 ? TRP A 466 ? PHE A 459 TRP A 465 1 ? 7  
HELX_P HELX_P29 AD2 ASN A 469 ? LYS A 479 ? ASN A 468 LYS A 478 1 ? 11 
HELX_P HELX_P30 AD3 VAL A 501 ? GLN A 506 ? VAL A 500 GLN A 505 5 ? 6  
HELX_P HELX_P31 AD4 HIS A 507 ? TRP A 511 ? HIS A 506 TRP A 510 5 ? 5  
HELX_P HELX_P32 AD5 TRP A 526 ? LYS A 531 ? TRP A 525 LYS A 530 1 ? 6  
HELX_P HELX_P33 AD6 LYS A 531 ? ALA A 547 ? LYS A 530 ALA A 546 1 ? 17 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            metalc1 
_struct_conn.conn_type_id                  metalc 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           ASP 
_struct_conn.ptnr1_label_seq_id            383 
_struct_conn.ptnr1_label_atom_id           OD2 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           F 
_struct_conn.ptnr2_label_comp_id           NA 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           NA 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            ASP 
_struct_conn.ptnr1_auth_seq_id             382 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            NA 
_struct_conn.ptnr2_auth_seq_id             605 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.938 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 LEU 17  A . ? LEU 16  A PRO 18  A ? PRO 17  A 1 -6.84  
2 LYS 161 A . ? LYS 160 A PRO 162 A ? PRO 161 A 1 8.88   
3 PHE 268 A . ? PHE 267 A PRO 269 A ? PRO 268 A 1 -11.33 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 8 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA3 5 6 ? parallel      
AA3 6 7 ? parallel      
AA3 7 8 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 150 ? GLU A 153 ? PHE A 149 GLU A 152 
AA1 2 THR A 119 ? THR A 124 ? THR A 118 THR A 123 
AA1 3 ALA A 6   ? PHE A 9   ? ALA A 5   PHE A 8   
AA1 4 VAL A 181 ? ASP A 185 ? VAL A 180 ASP A 184 
AA1 5 VAL A 200 ? LEU A 203 ? VAL A 199 LEU A 202 
AA2 1 ALA A 16  ? LEU A 17  ? ALA A 15  LEU A 16  
AA2 2 LYS A 101 ? ILE A 102 ? LYS A 100 ILE A 101 
AA3 1 SER A 239 ? LYS A 246 ? SER A 238 LYS A 245 
AA3 2 VAL A 249 ? LEU A 256 ? VAL A 248 LEU A 255 
AA3 3 ARG A 288 ? ASP A 293 ? ARG A 287 ASP A 292 
AA3 4 ALA A 261 ? CYS A 265 ? ALA A 260 CYS A 264 
AA3 5 ALA A 330 ? HIS A 335 ? ALA A 329 HIS A 334 
AA3 6 VAL A 353 ? LEU A 359 ? VAL A 352 LEU A 358 
AA3 7 ALA A 489 ? ALA A 494 ? ALA A 488 ALA A 493 
AA3 8 LYS A 516 ? ILE A 520 ? LYS A 515 ILE A 519 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ILE A 152 ? O ILE A 151 N ILE A 122 ? N ILE A 121 
AA1 2 3 O ALA A 121 ? O ALA A 120 N PHE A 9   ? N PHE A 8   
AA1 3 4 N VAL A 8   ? N VAL A 7   O LEU A 184 ? O LEU A 183 
AA1 4 5 N PHE A 183 ? N PHE A 182 O VAL A 200 ? O VAL A 199 
AA2 1 2 N LEU A 17  ? N LEU A 16  O LYS A 101 ? O LYS A 100 
AA3 1 2 N GLY A 241 ? N GLY A 240 O PHE A 253 ? O PHE A 252 
AA3 2 3 N LEU A 256 ? N LEU A 255 O VAL A 289 ? O VAL A 288 
AA3 3 4 O LEU A 290 ? O LEU A 289 N VAL A 262 ? N VAL A 261 
AA3 4 5 N CYS A 263 ? N CYS A 262 O VAL A 331 ? O VAL A 330 
AA3 5 6 N PHE A 332 ? N PHE A 331 O ALA A 355 ? O ALA A 354 
AA3 6 7 N SER A 358 ? N SER A 357 O VAL A 492 ? O VAL A 491 
AA3 7 8 N ALA A 489 ? N ALA A 488 O LYS A 516 ? O LYS A 515 
# 
_pdbx_entry_details.entry_id                   9EXM 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OE1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   GLN 
_pdbx_validate_close_contact.auth_seq_id_1    155 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   B 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    701 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.15 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LEU A 10  ? ? -90.30  -73.66  
2 1 VAL A 13  ? ? -124.10 -68.86  
3 1 GLN A 204 ? ? -111.51 -83.42  
4 1 ARG A 247 ? ? 73.17   -9.51   
5 1 GLU A 269 ? ? -115.67 -145.29 
6 1 ASP A 335 ? ? 61.92   -125.69 
7 1 ASN A 359 ? ? 77.10   -44.52  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 1173 ? G HOH . 
2 1 A HOH 1318 ? G HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1313 ? 5.88 . 
2 1 O ? A HOH 1314 ? 6.00 . 
3 1 O ? A HOH 1315 ? 6.28 . 
4 1 O ? A HOH 1316 ? 6.39 . 
5 1 O ? A HOH 1317 ? 6.56 . 
6 1 O ? A HOH 1318 ? 6.72 . 
7 1 O ? A HOH 1319 ? 8.13 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY 0   ? A GLY 1   
2 1 Y 1 A MET 1   ? A MET 2   
3 1 Y 1 A ASN 548 ? A ASN 549 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
GOL C1   C  N N 137 
GOL O1   O  N N 138 
GOL C2   C  N N 139 
GOL O2   O  N N 140 
GOL C3   C  N N 141 
GOL O3   O  N N 142 
GOL H11  H  N N 143 
GOL H12  H  N N 144 
GOL HO1  H  N N 145 
GOL H2   H  N N 146 
GOL HO2  H  N N 147 
GOL H31  H  N N 148 
GOL H32  H  N N 149 
GOL HO3  H  N N 150 
HIS N    N  N N 151 
HIS CA   C  N S 152 
HIS C    C  N N 153 
HIS O    O  N N 154 
HIS CB   C  N N 155 
HIS CG   C  Y N 156 
HIS ND1  N  Y N 157 
HIS CD2  C  Y N 158 
HIS CE1  C  Y N 159 
HIS NE2  N  Y N 160 
HIS OXT  O  N N 161 
HIS H    H  N N 162 
HIS H2   H  N N 163 
HIS HA   H  N N 164 
HIS HB2  H  N N 165 
HIS HB3  H  N N 166 
HIS HD1  H  N N 167 
HIS HD2  H  N N 168 
HIS HE1  H  N N 169 
HIS HE2  H  N N 170 
HIS HXT  H  N N 171 
HOH O    O  N N 172 
HOH H1   H  N N 173 
HOH H2   H  N N 174 
ILE N    N  N N 175 
ILE CA   C  N S 176 
ILE C    C  N N 177 
ILE O    O  N N 178 
ILE CB   C  N S 179 
ILE CG1  C  N N 180 
ILE CG2  C  N N 181 
ILE CD1  C  N N 182 
ILE OXT  O  N N 183 
ILE H    H  N N 184 
ILE H2   H  N N 185 
ILE HA   H  N N 186 
ILE HB   H  N N 187 
ILE HG12 H  N N 188 
ILE HG13 H  N N 189 
ILE HG21 H  N N 190 
ILE HG22 H  N N 191 
ILE HG23 H  N N 192 
ILE HD11 H  N N 193 
ILE HD12 H  N N 194 
ILE HD13 H  N N 195 
ILE HXT  H  N N 196 
LEU N    N  N N 197 
LEU CA   C  N S 198 
LEU C    C  N N 199 
LEU O    O  N N 200 
LEU CB   C  N N 201 
LEU CG   C  N N 202 
LEU CD1  C  N N 203 
LEU CD2  C  N N 204 
LEU OXT  O  N N 205 
LEU H    H  N N 206 
LEU H2   H  N N 207 
LEU HA   H  N N 208 
LEU HB2  H  N N 209 
LEU HB3  H  N N 210 
LEU HG   H  N N 211 
LEU HD11 H  N N 212 
LEU HD12 H  N N 213 
LEU HD13 H  N N 214 
LEU HD21 H  N N 215 
LEU HD22 H  N N 216 
LEU HD23 H  N N 217 
LEU HXT  H  N N 218 
LYS N    N  N N 219 
LYS CA   C  N S 220 
LYS C    C  N N 221 
LYS O    O  N N 222 
LYS CB   C  N N 223 
LYS CG   C  N N 224 
LYS CD   C  N N 225 
LYS CE   C  N N 226 
LYS NZ   N  N N 227 
LYS OXT  O  N N 228 
LYS H    H  N N 229 
LYS H2   H  N N 230 
LYS HA   H  N N 231 
LYS HB2  H  N N 232 
LYS HB3  H  N N 233 
LYS HG2  H  N N 234 
LYS HG3  H  N N 235 
LYS HD2  H  N N 236 
LYS HD3  H  N N 237 
LYS HE2  H  N N 238 
LYS HE3  H  N N 239 
LYS HZ1  H  N N 240 
LYS HZ2  H  N N 241 
LYS HZ3  H  N N 242 
LYS HXT  H  N N 243 
MET N    N  N N 244 
MET CA   C  N S 245 
MET C    C  N N 246 
MET O    O  N N 247 
MET CB   C  N N 248 
MET CG   C  N N 249 
MET SD   S  N N 250 
MET CE   C  N N 251 
MET OXT  O  N N 252 
MET H    H  N N 253 
MET H2   H  N N 254 
MET HA   H  N N 255 
MET HB2  H  N N 256 
MET HB3  H  N N 257 
MET HG2  H  N N 258 
MET HG3  H  N N 259 
MET HE1  H  N N 260 
MET HE2  H  N N 261 
MET HE3  H  N N 262 
MET HXT  H  N N 263 
NA  NA   NA N N 264 
PHE N    N  N N 265 
PHE CA   C  N S 266 
PHE C    C  N N 267 
PHE O    O  N N 268 
PHE CB   C  N N 269 
PHE CG   C  Y N 270 
PHE CD1  C  Y N 271 
PHE CD2  C  Y N 272 
PHE CE1  C  Y N 273 
PHE CE2  C  Y N 274 
PHE CZ   C  Y N 275 
PHE OXT  O  N N 276 
PHE H    H  N N 277 
PHE H2   H  N N 278 
PHE HA   H  N N 279 
PHE HB2  H  N N 280 
PHE HB3  H  N N 281 
PHE HD1  H  N N 282 
PHE HD2  H  N N 283 
PHE HE1  H  N N 284 
PHE HE2  H  N N 285 
PHE HZ   H  N N 286 
PHE HXT  H  N N 287 
PRO N    N  N N 288 
PRO CA   C  N S 289 
PRO C    C  N N 290 
PRO O    O  N N 291 
PRO CB   C  N N 292 
PRO CG   C  N N 293 
PRO CD   C  N N 294 
PRO OXT  O  N N 295 
PRO H    H  N N 296 
PRO HA   H  N N 297 
PRO HB2  H  N N 298 
PRO HB3  H  N N 299 
PRO HG2  H  N N 300 
PRO HG3  H  N N 301 
PRO HD2  H  N N 302 
PRO HD3  H  N N 303 
PRO HXT  H  N N 304 
SER N    N  N N 305 
SER CA   C  N S 306 
SER C    C  N N 307 
SER O    O  N N 308 
SER CB   C  N N 309 
SER OG   O  N N 310 
SER OXT  O  N N 311 
SER H    H  N N 312 
SER H2   H  N N 313 
SER HA   H  N N 314 
SER HB2  H  N N 315 
SER HB3  H  N N 316 
SER HG   H  N N 317 
SER HXT  H  N N 318 
SO4 S    S  N N 319 
SO4 O1   O  N N 320 
SO4 O2   O  N N 321 
SO4 O3   O  N N 322 
SO4 O4   O  N N 323 
THR N    N  N N 324 
THR CA   C  N S 325 
THR C    C  N N 326 
THR O    O  N N 327 
THR CB   C  N R 328 
THR OG1  O  N N 329 
THR CG2  C  N N 330 
THR OXT  O  N N 331 
THR H    H  N N 332 
THR H2   H  N N 333 
THR HA   H  N N 334 
THR HB   H  N N 335 
THR HG1  H  N N 336 
THR HG21 H  N N 337 
THR HG22 H  N N 338 
THR HG23 H  N N 339 
THR HXT  H  N N 340 
TRP N    N  N N 341 
TRP CA   C  N S 342 
TRP C    C  N N 343 
TRP O    O  N N 344 
TRP CB   C  N N 345 
TRP CG   C  Y N 346 
TRP CD1  C  Y N 347 
TRP CD2  C  Y N 348 
TRP NE1  N  Y N 349 
TRP CE2  C  Y N 350 
TRP CE3  C  Y N 351 
TRP CZ2  C  Y N 352 
TRP CZ3  C  Y N 353 
TRP CH2  C  Y N 354 
TRP OXT  O  N N 355 
TRP H    H  N N 356 
TRP H2   H  N N 357 
TRP HA   H  N N 358 
TRP HB2  H  N N 359 
TRP HB3  H  N N 360 
TRP HD1  H  N N 361 
TRP HE1  H  N N 362 
TRP HE3  H  N N 363 
TRP HZ2  H  N N 364 
TRP HZ3  H  N N 365 
TRP HH2  H  N N 366 
TRP HXT  H  N N 367 
TYR N    N  N N 368 
TYR CA   C  N S 369 
TYR C    C  N N 370 
TYR O    O  N N 371 
TYR CB   C  N N 372 
TYR CG   C  Y N 373 
TYR CD1  C  Y N 374 
TYR CD2  C  Y N 375 
TYR CE1  C  Y N 376 
TYR CE2  C  Y N 377 
TYR CZ   C  Y N 378 
TYR OH   O  N N 379 
TYR OXT  O  N N 380 
TYR H    H  N N 381 
TYR H2   H  N N 382 
TYR HA   H  N N 383 
TYR HB2  H  N N 384 
TYR HB3  H  N N 385 
TYR HD1  H  N N 386 
TYR HD2  H  N N 387 
TYR HE1  H  N N 388 
TYR HE2  H  N N 389 
TYR HH   H  N N 390 
TYR HXT  H  N N 391 
VAL N    N  N N 392 
VAL CA   C  N S 393 
VAL C    C  N N 394 
VAL O    O  N N 395 
VAL CB   C  N N 396 
VAL CG1  C  N N 397 
VAL CG2  C  N N 398 
VAL OXT  O  N N 399 
VAL H    H  N N 400 
VAL H2   H  N N 401 
VAL HA   H  N N 402 
VAL HB   H  N N 403 
VAL HG11 H  N N 404 
VAL HG12 H  N N 405 
VAL HG13 H  N N 406 
VAL HG21 H  N N 407 
VAL HG22 H  N N 408 
VAL HG23 H  N N 409 
VAL HXT  H  N N 410 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
SO4 S   O1   doub N N 303 
SO4 S   O2   doub N N 304 
SO4 S   O3   sing N N 305 
SO4 S   O4   sing N N 306 
THR N   CA   sing N N 307 
THR N   H    sing N N 308 
THR N   H2   sing N N 309 
THR CA  C    sing N N 310 
THR CA  CB   sing N N 311 
THR CA  HA   sing N N 312 
THR C   O    doub N N 313 
THR C   OXT  sing N N 314 
THR CB  OG1  sing N N 315 
THR CB  CG2  sing N N 316 
THR CB  HB   sing N N 317 
THR OG1 HG1  sing N N 318 
THR CG2 HG21 sing N N 319 
THR CG2 HG22 sing N N 320 
THR CG2 HG23 sing N N 321 
THR OXT HXT  sing N N 322 
TRP N   CA   sing N N 323 
TRP N   H    sing N N 324 
TRP N   H2   sing N N 325 
TRP CA  C    sing N N 326 
TRP CA  CB   sing N N 327 
TRP CA  HA   sing N N 328 
TRP C   O    doub N N 329 
TRP C   OXT  sing N N 330 
TRP CB  CG   sing N N 331 
TRP CB  HB2  sing N N 332 
TRP CB  HB3  sing N N 333 
TRP CG  CD1  doub Y N 334 
TRP CG  CD2  sing Y N 335 
TRP CD1 NE1  sing Y N 336 
TRP CD1 HD1  sing N N 337 
TRP CD2 CE2  doub Y N 338 
TRP CD2 CE3  sing Y N 339 
TRP NE1 CE2  sing Y N 340 
TRP NE1 HE1  sing N N 341 
TRP CE2 CZ2  sing Y N 342 
TRP CE3 CZ3  doub Y N 343 
TRP CE3 HE3  sing N N 344 
TRP CZ2 CH2  doub Y N 345 
TRP CZ2 HZ2  sing N N 346 
TRP CZ3 CH2  sing Y N 347 
TRP CZ3 HZ3  sing N N 348 
TRP CH2 HH2  sing N N 349 
TRP OXT HXT  sing N N 350 
TYR N   CA   sing N N 351 
TYR N   H    sing N N 352 
TYR N   H2   sing N N 353 
TYR CA  C    sing N N 354 
TYR CA  CB   sing N N 355 
TYR CA  HA   sing N N 356 
TYR C   O    doub N N 357 
TYR C   OXT  sing N N 358 
TYR CB  CG   sing N N 359 
TYR CB  HB2  sing N N 360 
TYR CB  HB3  sing N N 361 
TYR CG  CD1  doub Y N 362 
TYR CG  CD2  sing Y N 363 
TYR CD1 CE1  sing Y N 364 
TYR CD1 HD1  sing N N 365 
TYR CD2 CE2  doub Y N 366 
TYR CD2 HD2  sing N N 367 
TYR CE1 CZ   doub Y N 368 
TYR CE1 HE1  sing N N 369 
TYR CE2 CZ   sing Y N 370 
TYR CE2 HE2  sing N N 371 
TYR CZ  OH   sing N N 372 
TYR OH  HH   sing N N 373 
TYR OXT HXT  sing N N 374 
VAL N   CA   sing N N 375 
VAL N   H    sing N N 376 
VAL N   H2   sing N N 377 
VAL CA  C    sing N N 378 
VAL CA  CB   sing N N 379 
VAL CA  HA   sing N N 380 
VAL C   O    doub N N 381 
VAL C   OXT  sing N N 382 
VAL CB  CG1  sing N N 383 
VAL CB  CG2  sing N N 384 
VAL CB  HB   sing N N 385 
VAL CG1 HG11 sing N N 386 
VAL CG1 HG12 sing N N 387 
VAL CG1 HG13 sing N N 388 
VAL CG2 HG21 sing N N 389 
VAL CG2 HG22 sing N N 390 
VAL CG2 HG23 sing N N 391 
VAL OXT HXT  sing N N 392 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'The Swedish Foundation for Strategic Research' Sweden ID17-0060  1 
'Swedish Research Council'                      Sweden 2017-06734 2 
'Swedish Research Council'                      Sweden 2021-05662 3 
'Swedish Research Council'                      Sweden 2021-05981 4 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5ahx 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9EXM 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010735 
_atom_sites.fract_transf_matrix[1][2]   0.006198 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012395 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.004062 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
N  
NA 
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . THR A 1 3   ? 33.763 -37.361 23.146  1    48.34  ? 2    THR A N   1 
ATOM   2    C  CA  . THR A 1 3   ? 34.737 -38.36  22.709  1    47.65  ? 2    THR A CA  1 
ATOM   3    C  C   . THR A 1 3   ? 34.248 -39.122 21.465  1    45.52  ? 2    THR A C   1 
ATOM   4    O  O   . THR A 1 3   ? 35.083 -39.59  20.688  1    45.41  ? 2    THR A O   1 
ATOM   5    C  CB  . THR A 1 3   ? 35.174 -39.304 23.854  1    49.94  ? 2    THR A CB  1 
ATOM   6    O  OG1 . THR A 1 3   ? 34.252 -40.391 24.011  1    52.08  ? 2    THR A OG1 1 
ATOM   7    C  CG2 . THR A 1 3   ? 35.374 -38.584 25.185  1    50.87  ? 2    THR A CG2 1 
ATOM   8    N  N   . LEU A 1 4   ? 32.913 -39.272 21.288  1    43.24  ? 3    LEU A N   1 
ATOM   9    C  CA  . LEU A 1 4   ? 32.413 -39.99  20.11   1    41.84  ? 3    LEU A CA  1 
ATOM   10   C  C   . LEU A 1 4   ? 32.697 -39.184 18.865  1    40.84  ? 3    LEU A C   1 
ATOM   11   O  O   . LEU A 1 4   ? 32.521 -37.965 18.857  1    41.03  ? 3    LEU A O   1 
ATOM   12   C  CB  . LEU A 1 4   ? 30.908 -40.28  20.169  1    41.46  ? 3    LEU A CB  1 
ATOM   13   C  CG  . LEU A 1 4   ? 30.425 -41.285 21.194  1    43.28  ? 3    LEU A CG  1 
ATOM   14   C  CD1 . LEU A 1 4   ? 28.913 -41.344 21.201  1    44.1   ? 3    LEU A CD1 1 
ATOM   15   C  CD2 . LEU A 1 4   ? 30.971 -42.679 20.912  1    43.48  ? 3    LEU A CD2 1 
ATOM   16   N  N   . ARG A 1 5   ? 33.175 -39.854 17.822  1    39.61  ? 4    ARG A N   1 
ATOM   17   C  CA  . ARG A 1 5   ? 33.403 -39.182 16.546  1    39.21  ? 4    ARG A CA  1 
ATOM   18   C  C   . ARG A 1 5   ? 33.037 -40.076 15.34   1    36.91  ? 4    ARG A C   1 
ATOM   19   O  O   . ARG A 1 5   ? 33.253 -39.667 14.204  1    36.94  ? 4    ARG A O   1 
ATOM   20   C  CB  . ARG A 1 5   ? 34.811 -38.588 16.435  1    42.46  ? 4    ARG A CB  1 
ATOM   21   C  CG  . ARG A 1 5   ? 35.899 -39.628 16.483  1    47.79  ? 4    ARG A CG  1 
ATOM   22   C  CD  . ARG A 1 5   ? 37.257 -38.981 16.37   1    53     ? 4    ARG A CD  1 
ATOM   23   N  NE  . ARG A 1 5   ? 38.284 -39.974 16.048  1    56.45  ? 4    ARG A NE  1 
ATOM   24   C  CZ  . ARG A 1 5   ? 38.638 -40.311 14.814  1    59     ? 4    ARG A CZ  1 
ATOM   25   N  NH1 . ARG A 1 5   ? 39.572 -41.231 14.615  1    59.95  ? 4    ARG A NH1 1 
ATOM   26   N  NH2 . ARG A 1 5   ? 38.062 -39.731 13.768  1    58.25  ? 4    ARG A NH2 1 
ATOM   27   N  N   . ALA A 1 6   ? 32.414 -41.252 15.579  1    34.71  ? 5    ALA A N   1 
ATOM   28   C  CA  . ALA A 1 6   ? 31.981 -42.112 14.487  1    33.77  ? 5    ALA A CA  1 
ATOM   29   C  C   . ALA A 1 6   ? 30.674 -42.795 14.799  1    31.96  ? 5    ALA A C   1 
ATOM   30   O  O   . ALA A 1 6   ? 30.438 -43.196 15.935  1    32.26  ? 5    ALA A O   1 
ATOM   31   C  CB  . ALA A 1 6   ? 33.051 -43.139 14.142  1    34.06  ? 5    ALA A CB  1 
ATOM   32   N  N   . ALA A 1 7   ? 29.795 -42.911 13.796  1    30.08  ? 6    ALA A N   1 
ATOM   33   C  CA  . ALA A 1 7   ? 28.514 -43.578 13.984  1    28.92  ? 6    ALA A CA  1 
ATOM   34   C  C   . ALA A 1 7   ? 28.337 -44.62  12.909  1    27.96  ? 6    ALA A C   1 
ATOM   35   O  O   . ALA A 1 7   ? 28.525 -44.322 11.726  1    28.41  ? 6    ALA A O   1 
ATOM   36   C  CB  . ALA A 1 7   ? 27.371 -42.564 13.947  1    29.04  ? 6    ALA A CB  1 
ATOM   37   N  N   . VAL A 1 8   ? 27.974 -45.845 13.312  1    26.81  ? 7    VAL A N   1 
ATOM   38   C  CA  . VAL A 1 8   ? 27.806 -46.986 12.44   1    26.49  ? 7    VAL A CA  1 
ATOM   39   C  C   . VAL A 1 8   ? 26.391 -47.495 12.545  1    26.69  ? 7    VAL A C   1 
ATOM   40   O  O   . VAL A 1 8   ? 25.881 -47.742 13.65   1    27.28  ? 7    VAL A O   1 
ATOM   41   C  CB  . VAL A 1 8   ? 28.836 -48.103 12.789  1    26.97  ? 7    VAL A CB  1 
ATOM   42   C  CG1 . VAL A 1 8   ? 28.717 -49.267 11.82   1    27.95  ? 7    VAL A CG1 1 
ATOM   43   C  CG2 . VAL A 1 8   ? 30.257 -47.556 12.835  1    26.96  ? 7    VAL A CG2 1 
ATOM   44   N  N   . PHE A 1 9   ? 25.739 -47.647 11.398  1    25.66  ? 8    PHE A N   1 
ATOM   45   C  CA  . PHE A 1 9   ? 24.364 -48.099 11.305  1    25.3   ? 8    PHE A CA  1 
ATOM   46   C  C   . PHE A 1 9   ? 24.21  -49.409 10.531  1    26.28  ? 8    PHE A C   1 
ATOM   47   O  O   . PHE A 1 9   ? 24.808 -49.608 9.461   1    26.59  ? 8    PHE A O   1 
ATOM   48   C  CB  . PHE A 1 9   ? 23.531 -46.999 10.568  1    25.01  ? 8    PHE A CB  1 
ATOM   49   C  CG  . PHE A 1 9   ? 23.544 -45.633 11.208  1    24.5   ? 8    PHE A CG  1 
ATOM   50   C  CD1 . PHE A 1 9   ? 24.638 -44.793 11.071  1    25     ? 8    PHE A CD1 1 
ATOM   51   C  CD2 . PHE A 1 9   ? 22.451 -45.178 11.925  1    24.86  ? 8    PHE A CD2 1 
ATOM   52   C  CE1 . PHE A 1 9   ? 24.656 -43.539 11.663  1    25.24  ? 8    PHE A CE1 1 
ATOM   53   C  CE2 . PHE A 1 9   ? 22.454 -43.911 12.497  1    25.07  ? 8    PHE A CE2 1 
ATOM   54   C  CZ  . PHE A 1 9   ? 23.572 -43.112 12.404  1    25.24  ? 8    PHE A CZ  1 
ATOM   55   N  N   . ASP A 1 10  ? 23.348 -50.283 11.024  1    26.68  ? 9    ASP A N   1 
ATOM   56   C  CA  . ASP A 1 10  ? 22.969 -51.488 10.293  1    27.6   ? 9    ASP A CA  1 
ATOM   57   C  C   . ASP A 1 10  ? 21.958 -51.047 9.2     1    28.1   ? 9    ASP A C   1 
ATOM   58   O  O   . ASP A 1 10  ? 21.368 -49.953 9.283   1    29.17  ? 9    ASP A O   1 
ATOM   59   C  CB  . ASP A 1 10  ? 22.271 -52.487 11.244  1    30.18  ? 9    ASP A CB  1 
ATOM   60   C  CG  . ASP A 1 10  ? 21.957 -53.849 10.63   1    36.13  ? 9    ASP A CG  1 
ATOM   61   O  OD1 . ASP A 1 10  ? 22.587 -54.204 9.607   1    36.74  ? 9    ASP A OD1 1 
ATOM   62   O  OD2 . ASP A 1 10  ? 21.085 -54.56  11.173  1    39.48  ? 9    ASP A OD2 1 
ATOM   63   N  N   . LEU A 1 11  ? 21.734 -51.894 8.215   1    27.79  ? 10   LEU A N   1 
ATOM   64   C  CA  . LEU A 1 11  ? 20.766 -51.598 7.165   1    28.26  ? 10   LEU A CA  1 
ATOM   65   C  C   . LEU A 1 11  ? 19.363 -52.126 7.547   1    28.28  ? 10   LEU A C   1 
ATOM   66   O  O   . LEU A 1 11  ? 18.503 -51.33  7.921   1    28.37  ? 10   LEU A O   1 
ATOM   67   C  CB  . LEU A 1 11  ? 21.272 -52.094 5.802   1    28.73  ? 10   LEU A CB  1 
ATOM   68   C  CG  . LEU A 1 11  ? 20.257 -52.102 4.654   1    31.26  ? 10   LEU A CG  1 
ATOM   69   C  CD1 . LEU A 1 11  ? 19.94  -50.713 4.222   1    31.17  ? 10   LEU A CD1 1 
ATOM   70   C  CD2 . LEU A 1 11  ? 20.783 -52.918 3.479   1    33.15  ? 10   LEU A CD2 1 
ATOM   71   N  N   . ASP A 1 12  ? 19.142 -53.439 7.495   1    28.89  ? 11   ASP A N   1 
ATOM   72   C  CA  . ASP A 1 12  ? 17.833 -54.02  7.802   1    29.97  ? 11   ASP A CA  1 
ATOM   73   C  C   . ASP A 1 12  ? 17.366 -53.679 9.212   1    30.21  ? 11   ASP A C   1 
ATOM   74   O  O   . ASP A 1 12  ? 18.075 -53.939 10.185  1    31.46  ? 11   ASP A O   1 
ATOM   75   C  CB  . ASP A 1 12  ? 17.881 -55.535 7.632   1    31.96  ? 11   ASP A CB  1 
ATOM   76   C  CG  . ASP A 1 12  ? 16.528 -56.124 7.341   1    36.26  ? 11   ASP A CG  1 
ATOM   77   O  OD1 . ASP A 1 12  ? 15.851 -55.624 6.424   1    34.64  ? 11   ASP A OD1 1 
ATOM   78   O  OD2 . ASP A 1 12  ? 16.142 -57.106 8.024   1    38.77  ? 11   ASP A OD2 1 
ATOM   79   N  N   . GLY A 1 13  ? 16.21  -53.041 9.32    1    29.52  ? 12   GLY A N   1 
ATOM   80   C  CA  . GLY A 1 13  ? 15.652 -52.698 10.628  1    28.94  ? 12   GLY A CA  1 
ATOM   81   C  C   . GLY A 1 13  ? 16.203 -51.446 11.277  1    28.59  ? 12   GLY A C   1 
ATOM   82   O  O   . GLY A 1 13  ? 15.724 -51.031 12.335  1    29.91  ? 12   GLY A O   1 
ATOM   83   N  N   . VAL A 1 14  ? 17.201 -50.791 10.654  1    26.75  ? 13   VAL A N   1 
ATOM   84   C  CA  . VAL A 1 14  ? 17.761 -49.558 11.199  1    25.93  ? 13   VAL A CA  1 
ATOM   85   C  C   . VAL A 1 14  ? 17.653 -48.479 10.135  1    26.99  ? 13   VAL A C   1 
ATOM   86   O  O   . VAL A 1 14  ? 16.82  -47.582 10.278  1    27.89  ? 13   VAL A O   1 
ATOM   87   C  CB  . VAL A 1 14  ? 19.198 -49.741 11.75   1    27.54  ? 13   VAL A CB  1 
ATOM   88   C  CG1 . VAL A 1 14  ? 19.736 -48.411 12.292  1    28.02  ? 13   VAL A CG1 1 
ATOM   89   C  CG2 . VAL A 1 14  ? 19.226 -50.842 12.821  1    28.76  ? 13   VAL A CG2 1 
ATOM   90   N  N   . LEU A 1 15  ? 18.424 -48.584 9.027   1    26.08  ? 14   LEU A N   1 
ATOM   91   C  CA  . LEU A 1 15  ? 18.306 -47.584 7.953   1    26.68  ? 14   LEU A CA  1 
ATOM   92   C  C   . LEU A 1 15  ? 17.176 -47.88  6.968   1    28.2   ? 14   LEU A C   1 
ATOM   93   O  O   . LEU A 1 15  ? 16.84  -46.999 6.168   1    28.72  ? 14   LEU A O   1 
ATOM   94   C  CB  . LEU A 1 15  ? 19.638 -47.428 7.194   1    25.35  ? 14   LEU A CB  1 
ATOM   95   C  CG  . LEU A 1 15  ? 20.692 -46.642 7.941   1    26.45  ? 14   LEU A CG  1 
ATOM   96   C  CD1 . LEU A 1 15  ? 22.058 -46.826 7.277   1    26.8   ? 14   LEU A CD1 1 
ATOM   97   C  CD2 . LEU A 1 15  ? 20.34  -45.163 8.019   1    26.15  ? 14   LEU A CD2 1 
ATOM   98   N  N   . ALA A 1 16  ? 16.624 -49.101 6.962   1    27.99  ? 15   ALA A N   1 
ATOM   99   C  CA  . ALA A 1 16  ? 15.558 -49.471 6.036   1    29.36  ? 15   ALA A CA  1 
ATOM   100  C  C   . ALA A 1 16  ? 14.491 -50.315 6.742   1    30.91  ? 15   ALA A C   1 
ATOM   101  O  O   . ALA A 1 16  ? 14.833 -51.218 7.511   1    31.8   ? 15   ALA A O   1 
ATOM   102  C  CB  . ALA A 1 16  ? 16.134 -50.247 4.86    1    29.59  ? 15   ALA A CB  1 
ATOM   103  N  N   . LEU A 1 17  ? 13.206 -49.992 6.497   1    31.04  ? 16   LEU A N   1 
ATOM   104  C  CA  . LEU A 1 17  ? 12.057 -50.642 7.141   1    32.85  ? 16   LEU A CA  1 
ATOM   105  C  C   . LEU A 1 17  ? 10.896 -50.807 6.148   1    35.18  ? 16   LEU A C   1 
ATOM   106  O  O   . LEU A 1 17  ? 10.722 -49.967 5.255   1    35.74  ? 16   LEU A O   1 
ATOM   107  C  CB  . LEU A 1 17  ? 11.555 -49.745 8.284   1    33.08  ? 16   LEU A CB  1 
ATOM   108  C  CG  . LEU A 1 17  ? 12.449 -49.533 9.481   1    34.89  ? 16   LEU A CG  1 
ATOM   109  C  CD1 . LEU A 1 17  ? 11.871 -48.458 10.396  1    35.1   ? 16   LEU A CD1 1 
ATOM   110  C  CD2 . LEU A 1 17  ? 12.579 -50.808 10.271  1    35.72  ? 16   LEU A CD2 1 
ATOM   111  N  N   . PRO A 1 18  ? 9.997  -51.786 6.365   1    36.45  ? 17   PRO A N   1 
ATOM   112  C  CA  . PRO A 1 18  ? 10.064 -52.837 7.393   1    36.9   ? 17   PRO A CA  1 
ATOM   113  C  C   . PRO A 1 18  ? 11.217 -53.788 7.138   1    36.34  ? 17   PRO A C   1 
ATOM   114  O  O   . PRO A 1 18  ? 11.534 -54.073 5.982   1    36.63  ? 17   PRO A O   1 
ATOM   115  C  CB  . PRO A 1 18  ? 8.717  -53.57  7.239   1    38.01  ? 17   PRO A CB  1 
ATOM   116  C  CG  . PRO A 1 18  ? 8.307  -53.333 5.828   1    38.67  ? 17   PRO A CG  1 
ATOM   117  C  CD  . PRO A 1 18  ? 8.823  -51.953 5.486   1    36.8   ? 17   PRO A CD  1 
ATOM   118  N  N   . ALA A 1 19  ? 11.836 -54.3   8.212   1    35.09  ? 18   ALA A N   1 
ATOM   119  C  CA  . ALA A 1 19  ? 12.935 -55.25  8.087   1    35.14  ? 18   ALA A CA  1 
ATOM   120  C  C   . ALA A 1 19  ? 12.541 -56.485 7.29    1    35.73  ? 18   ALA A C   1 
ATOM   121  O  O   . ALA A 1 19  ? 11.505 -57.09  7.572   1    36.43  ? 18   ALA A O   1 
ATOM   122  C  CB  . ALA A 1 19  ? 13.392 -55.681 9.469   1    35.19  ? 18   ALA A CB  1 
ATOM   123  N  N   . VAL A 1 20  ? 13.364 -56.875 6.294   1    34.74  ? 19   VAL A N   1 
ATOM   124  C  CA  . VAL A 1 20  ? 13.191 -58.075 5.494   1    35.48  ? 19   VAL A CA  1 
ATOM   125  C  C   . VAL A 1 20  ? 13.17  -59.295 6.413   1    37.59  ? 19   VAL A C   1 
ATOM   126  O  O   . VAL A 1 20  ? 12.313 -60.146 6.258   1    38.39  ? 19   VAL A O   1 
ATOM   127  C  CB  . VAL A 1 20  ? 14.313 -58.196 4.43    1    35.34  ? 19   VAL A CB  1 
ATOM   128  C  CG1 . VAL A 1 20  ? 14.366 -59.598 3.825   1    35.76  ? 19   VAL A CG1 1 
ATOM   129  C  CG2 . VAL A 1 20  ? 14.117 -57.148 3.332   1    35.68  ? 19   VAL A CG2 1 
ATOM   130  N  N   . PHE A 1 21  ? 14.077 -59.345 7.392   1    38.6   ? 20   PHE A N   1 
ATOM   131  C  CA  . PHE A 1 21  ? 14.148 -60.459 8.347   1    40.47  ? 20   PHE A CA  1 
ATOM   132  C  C   . PHE A 1 21  ? 12.824 -60.686 9.102   1    41.09  ? 20   PHE A C   1 
ATOM   133  O  O   . PHE A 1 21  ? 12.536 -61.817 9.506   1    42     ? 20   PHE A O   1 
ATOM   134  C  CB  . PHE A 1 21  ? 15.308 -60.244 9.338   1    41.73  ? 20   PHE A CB  1 
ATOM   135  C  CG  . PHE A 1 21  ? 16.669 -60.615 8.789   1    44.29  ? 20   PHE A CG  1 
ATOM   136  C  CD1 . PHE A 1 21  ? 16.989 -60.379 7.459   1    45.84  ? 20   PHE A CD1 1 
ATOM   137  C  CD2 . PHE A 1 21  ? 17.631 -61.19  9.606   1    45.98  ? 20   PHE A CD2 1 
ATOM   138  C  CE1 . PHE A 1 21  ? 18.234 -60.736 6.952   1    47.18  ? 20   PHE A CE1 1 
ATOM   139  C  CE2 . PHE A 1 21  ? 18.886 -61.525 9.101   1    47.02  ? 20   PHE A CE2 1 
ATOM   140  C  CZ  . PHE A 1 21  ? 19.179 -61.292 7.781   1    47.02  ? 20   PHE A CZ  1 
ATOM   141  N  N   . GLY A 1 22  ? 12.035 -59.626 9.273   1    40.66  ? 21   GLY A N   1 
ATOM   142  C  CA  . GLY A 1 22  ? 10.735 -59.685 9.935   1    40.86  ? 21   GLY A CA  1 
ATOM   143  C  C   . GLY A 1 22  ? 9.667  -60.42  9.143   1    41.08  ? 21   GLY A C   1 
ATOM   144  O  O   . GLY A 1 22  ? 8.623  -60.794 9.701   1    41.29  ? 21   GLY A O   1 
ATOM   145  N  N   . VAL A 1 23  ? 9.914  -60.647 7.832   1    40.1   ? 22   VAL A N   1 
ATOM   146  C  CA  . VAL A 1 23  ? 8.972  -61.343 6.969   1    39.48  ? 22   VAL A CA  1 
ATOM   147  C  C   . VAL A 1 23  ? 8.833  -62.812 7.345   1    38.71  ? 22   VAL A C   1 
ATOM   148  O  O   . VAL A 1 23  ? 7.809  -63.41  7.029   1    39.25  ? 22   VAL A O   1 
ATOM   149  C  CB  . VAL A 1 23  ? 9.284  -61.149 5.452   1    40.18  ? 22   VAL A CB  1 
ATOM   150  C  CG1 . VAL A 1 23  ? 10.249 -62.214 4.925   1    40.65  ? 22   VAL A CG1 1 
ATOM   151  C  CG2 . VAL A 1 23  ? 7.999  -61.154 4.638   1    40.71  ? 22   VAL A CG2 1 
ATOM   152  N  N   . LEU A 1 24  ? 9.853  -63.411 7.999   1    37.76  ? 23   LEU A N   1 
ATOM   153  C  CA  . LEU A 1 24  ? 9.763  -64.809 8.383   1    37.8   ? 23   LEU A CA  1 
ATOM   154  C  C   . LEU A 1 24  ? 8.667  -64.982 9.431   1    36.99  ? 23   LEU A C   1 
ATOM   155  O  O   . LEU A 1 24  ? 7.789  -65.818 9.233   1    37.3   ? 23   LEU A O   1 
ATOM   156  C  CB  . LEU A 1 24  ? 11.116 -65.334 8.837   1    38.55  ? 23   LEU A CB  1 
ATOM   157  C  CG  . LEU A 1 24  ? 12.185 -65.216 7.738   1    40.65  ? 23   LEU A CG  1 
ATOM   158  C  CD1 . LEU A 1 24  ? 13.566 -65.433 8.288   1    42.38  ? 23   LEU A CD1 1 
ATOM   159  C  CD2 . LEU A 1 24  ? 11.897 -66.152 6.601   1    41.14  ? 23   LEU A CD2 1 
ATOM   160  N  N   . GLY A 1 25  ? 8.65   -64.11  10.439  1    36.59  ? 24   GLY A N   1 
ATOM   161  C  CA  . GLY A 1 25  ? 7.619  -64.131 11.48   1    36.21  ? 24   GLY A CA  1 
ATOM   162  C  C   . GLY A 1 25  ? 6.239  -63.788 10.945  1    35.54  ? 24   GLY A C   1 
ATOM   163  O  O   . GLY A 1 25  ? 5.239  -64.433 11.305  1    34.67  ? 24   GLY A O   1 
ATOM   164  N  N   . ARG A 1 26  ? 6.177  -62.79  10.033  1    34.86  ? 25   ARG A N   1 
ATOM   165  C  CA  . ARG A 1 26  ? 4.917  -62.364 9.416   1    35.43  ? 25   ARG A CA  1 
ATOM   166  C  C   . ARG A 1 26  ? 4.339  -63.469 8.531   1    34.66  ? 25   ARG A C   1 
ATOM   167  O  O   . ARG A 1 26  ? 3.126  -63.653 8.499   1    35.33  ? 25   ARG A O   1 
ATOM   168  C  CB  . ARG A 1 26  ? 5.092  -61.056 8.609   1    37.95  ? 25   ARG A CB  1 
ATOM   169  C  CG  . ARG A 1 26  ? 5.28   -59.817 9.486   1    43.09  ? 25   ARG A CG  1 
ATOM   170  C  CD  . ARG A 1 26  ? 5.297  -58.525 8.672   1    47.62  ? 25   ARG A CD  1 
ATOM   171  N  NE  . ARG A 1 26  ? 6.469  -58.417 7.788   1    51.39  ? 25   ARG A NE  1 
ATOM   172  C  CZ  . ARG A 1 26  ? 7.588  -57.769 8.106   1    54.38  ? 25   ARG A CZ  1 
ATOM   173  N  NH1 . ARG A 1 26  ? 7.715  -57.192 9.295   1    55.36  ? 25   ARG A NH1 1 
ATOM   174  N  NH2 . ARG A 1 26  ? 8.599  -57.715 7.247   1    53.73  ? 25   ARG A NH2 1 
ATOM   175  N  N   . THR A 1 27  ? 5.194  -64.22  7.843   1    33.71  ? 26   THR A N   1 
ATOM   176  C  CA  . THR A 1 27  ? 4.749  -65.314 6.984   1    33.97  ? 26   THR A CA  1 
ATOM   177  C  C   . THR A 1 27  ? 4.247  -66.461 7.831   1    33.32  ? 26   THR A C   1 
ATOM   178  O  O   . THR A 1 27  ? 3.205  -67.023 7.526   1    32.99  ? 26   THR A O   1 
ATOM   179  C  CB  . THR A 1 27  ? 5.847  -65.752 6.015   1    36.42  ? 26   THR A CB  1 
ATOM   180  O  OG1 . THR A 1 27  ? 6.286  -64.6   5.292   1    37.84  ? 26   THR A OG1 1 
ATOM   181  C  CG2 . THR A 1 27  ? 5.372  -66.823 5.049   1    37.08  ? 26   THR A CG2 1 
ATOM   182  N  N   . GLU A 1 28  ? 4.955  -66.778 8.927   1    32.51  ? 27   GLU A N   1 
ATOM   183  C  CA  . GLU A 1 28  ? 4.505  -67.829 9.834   1    33.27  ? 27   GLU A CA  1 
ATOM   184  C  C   . GLU A 1 28  ? 3.095  -67.526 10.367  1    34.28  ? 27   GLU A C   1 
ATOM   185  O  O   . GLU A 1 28  ? 2.24   -68.395 10.297  1    35.05  ? 27   GLU A O   1 
ATOM   186  C  CB  . GLU A 1 28  ? 5.45   -67.941 11.025  1    34.88  ? 27   GLU A CB  1 
ATOM   187  C  CG  . GLU A 1 28  ? 6.792  -68.576 10.732  1    38.41  ? 27   GLU A CG  1 
ATOM   188  C  CD  . GLU A 1 28  ? 7.843  -68.219 11.768  1    41.75  ? 27   GLU A CD  1 
ATOM   189  O  OE1 . GLU A 1 28  ? 7.489  -67.675 12.842  1    39.91  ? 27   GLU A OE1 1 
ATOM   190  O  OE2 . GLU A 1 28  ? 9.031  -68.522 11.519  1    42.99  ? 27   GLU A OE2 1 
ATOM   191  N  N   . GLU A 1 29  ? 2.851  -66.284 10.818  1    34.67  ? 28   GLU A N   1 
ATOM   192  C  CA  . GLU A 1 29  ? 1.545  -65.868 11.345  1    36.25  ? 28   GLU A CA  1 
ATOM   193  C  C   . GLU A 1 29  ? 0.452  -65.861 10.272  1    38.24  ? 28   GLU A C   1 
ATOM   194  O  O   . GLU A 1 29  ? -0.629 -66.387 10.524  1    38.77  ? 28   GLU A O   1 
ATOM   195  C  CB  . GLU A 1 29  ? 1.639  -64.502 12.026  1    38.62  ? 28   GLU A CB  1 
ATOM   196  C  CG  . GLU A 1 29  ? 2.339  -64.561 13.375  1    44.81  ? 28   GLU A CG  1 
ATOM   197  C  CD  . GLU A 1 29  ? 2.071  -63.393 14.307  1    53.28  ? 28   GLU A CD  1 
ATOM   198  O  OE1 . GLU A 1 29  ? 1.599  -62.338 13.821  1    55.73  ? 28   GLU A OE1 1 
ATOM   199  O  OE2 . GLU A 1 29  ? 2.341  -63.529 15.524  1    53.9   ? 28   GLU A OE2 1 
ATOM   200  N  N   . ALA A 1 30  ? 0.749  -65.342 9.055   1    38.2   ? 29   ALA A N   1 
ATOM   201  C  CA  . ALA A 1 30  ? -0.255 -65.327 7.98    1    39.51  ? 29   ALA A CA  1 
ATOM   202  C  C   . ALA A 1 30  ? -0.657 -66.732 7.54    1    40.42  ? 29   ALA A C   1 
ATOM   203  O  O   . ALA A 1 30  ? -1.834 -66.97  7.26    1    41.89  ? 29   ALA A O   1 
ATOM   204  C  CB  . ALA A 1 30  ? 0.259  -64.533 6.778   1    39.81  ? 29   ALA A CB  1 
ATOM   205  N  N   . LEU A 1 31  ? 0.299  -67.669 7.513   1    39.77  ? 30   LEU A N   1 
ATOM   206  C  CA  . LEU A 1 31  ? 0.046  -69.051 7.104   1    39.78  ? 30   LEU A CA  1 
ATOM   207  C  C   . LEU A 1 31  ? -0.314 -69.99  8.262   1    39.76  ? 30   LEU A C   1 
ATOM   208  O  O   . LEU A 1 31  ? -0.515 -71.177 8.016   1    39.84  ? 30   LEU A O   1 
ATOM   209  C  CB  . LEU A 1 31  ? 1.283  -69.622 6.407   1    40.18  ? 30   LEU A CB  1 
ATOM   210  C  CG  . LEU A 1 31  ? 1.831  -68.854 5.203   1    42.2   ? 30   LEU A CG  1 
ATOM   211  C  CD1 . LEU A 1 31  ? 3.031  -69.596 4.608   1    43.11  ? 30   LEU A CD1 1 
ATOM   212  C  CD2 . LEU A 1 31  ? 0.756  -68.658 4.145   1    43.02  ? 30   LEU A CD2 1 
ATOM   213  N  N   . ALA A 1 32  ? -0.346 -69.483 9.513   1    39.04  ? 31   ALA A N   1 
ATOM   214  C  CA  . ALA A 1 32  ? -0.614 -70.274 10.718  1    38.63  ? 31   ALA A CA  1 
ATOM   215  C  C   . ALA A 1 32  ? 0.37   -71.456 10.834  1    38.36  ? 31   ALA A C   1 
ATOM   216  O  O   . ALA A 1 32  ? -0.022 -72.585 11.143  1    39.12  ? 31   ALA A O   1 
ATOM   217  C  CB  . ALA A 1 32  ? -2.065 -70.759 10.75   1    38.91  ? 31   ALA A CB  1 
ATOM   218  N  N   . LEU A 1 33  ? 1.652  -71.197 10.56   1    36.77  ? 32   LEU A N   1 
ATOM   219  C  CA  . LEU A 1 33  ? 2.701  -72.202 10.722  1    36.83  ? 32   LEU A CA  1 
ATOM   220  C  C   . LEU A 1 33  ? 3.156  -72.161 12.186  1    36.1   ? 32   LEU A C   1 
ATOM   221  O  O   . LEU A 1 33  ? 3.065  -71.103 12.808  1    35.39  ? 32   LEU A O   1 
ATOM   222  C  CB  . LEU A 1 33  ? 3.909  -71.803 9.843   1    37.36  ? 32   LEU A CB  1 
ATOM   223  C  CG  . LEU A 1 33  ? 3.658  -71.794 8.342   1    39.35  ? 32   LEU A CG  1 
ATOM   224  C  CD1 . LEU A 1 33  ? 4.894  -71.237 7.597   1    39.95  ? 32   LEU A CD1 1 
ATOM   225  C  CD2 . LEU A 1 33  ? 3.285  -73.193 7.854   1    40.27  ? 32   LEU A CD2 1 
ATOM   226  N  N   . PRO A 1 34  ? 3.824  -73.217 12.705  1    36.07  ? 33   PRO A N   1 
ATOM   227  C  CA  . PRO A 1 34  ? 4.361  -73.141 14.078  1    36.16  ? 33   PRO A CA  1 
ATOM   228  C  C   . PRO A 1 34  ? 5.284  -71.954 14.267  1    35.96  ? 33   PRO A C   1 
ATOM   229  O  O   . PRO A 1 34  ? 6.048  -71.634 13.351  1    36.42  ? 33   PRO A O   1 
ATOM   230  C  CB  . PRO A 1 34  ? 5.156  -74.439 14.218  1    37.09  ? 33   PRO A CB  1 
ATOM   231  C  CG  . PRO A 1 34  ? 4.55   -75.351 13.269  1    37.58  ? 33   PRO A CG  1 
ATOM   232  C  CD  . PRO A 1 34  ? 4.072  -74.539 12.102  1    36.13  ? 33   PRO A CD  1 
ATOM   233  N  N   . ARG A 1 35  ? 5.225  -71.286 15.424  1    34.4   ? 34   ARG A N   1 
ATOM   234  C  CA  . ARG A 1 35  ? 6.061  -70.115 15.669  1    34.73  ? 34   ARG A CA  1 
ATOM   235  C  C   . ARG A 1 35  ? 7.546  -70.467 15.542  1    34.97  ? 34   ARG A C   1 
ATOM   236  O  O   . ARG A 1 35  ? 7.967  -71.544 15.976  1    34.73  ? 34   ARG A O   1 
ATOM   237  C  CB  . ARG A 1 35  ? 5.796  -69.478 17.043  1    35.98  ? 34   ARG A CB  1 
ATOM   238  C  CG  . ARG A 1 35  ? 4.39   -68.955 17.25   1    37.14  ? 34   ARG A CG  1 
ATOM   239  C  CD  . ARG A 1 35  ? 4.368  -67.948 18.377  1    39.72  ? 34   ARG A CD  1 
ATOM   240  N  NE  . ARG A 1 35  ? 3.048  -67.331 18.546  1    41.91  ? 34   ARG A NE  1 
ATOM   241  C  CZ  . ARG A 1 35  ? 2.625  -66.277 17.848  1    44.97  ? 34   ARG A CZ  1 
ATOM   242  N  NH1 . ARG A 1 35  ? 3.408  -65.722 16.926  1    44.43  ? 34   ARG A NH1 1 
ATOM   243  N  NH2 . ARG A 1 35  ? 1.414  -65.777 18.057  1    43.23  ? 34   ARG A NH2 1 
ATOM   244  N  N   . GLY A 1 36  ? 8.267  -69.609 14.838  1    35.03  ? 35   GLY A N   1 
ATOM   245  C  CA  . GLY A 1 36  ? 9.694  -69.77  14.604  1    35.98  ? 35   GLY A CA  1 
ATOM   246  C  C   . GLY A 1 36  ? 10.103 -70.752 13.527  1    37.15  ? 35   GLY A C   1 
ATOM   247  O  O   . GLY A 1 36  ? 11.295 -70.869 13.268  1    37.61  ? 35   GLY A O   1 
ATOM   248  N  N   . LEU A 1 37  ? 9.167  -71.461 12.884  1    37.09  ? 36   LEU A N   1 
ATOM   249  C  CA  . LEU A 1 37  ? 9.513  -72.446 11.859  1    37.88  ? 36   LEU A CA  1 
ATOM   250  C  C   . LEU A 1 37  ? 10.428 -71.891 10.733  1    38.24  ? 36   LEU A C   1 
ATOM   251  O  O   . LEU A 1 37  ? 11.473 -72.469 10.435  1    38.51  ? 36   LEU A O   1 
ATOM   252  C  CB  . LEU A 1 37  ? 8.255  -73.043 11.244  1    38.98  ? 36   LEU A CB  1 
ATOM   253  C  CG  . LEU A 1 37  ? 8.497  -74.29  10.439  1    42.51  ? 36   LEU A CG  1 
ATOM   254  C  CD1 . LEU A 1 37  ? 8.539  -75.491 11.352  1    44.2   ? 36   LEU A CD1 1 
ATOM   255  C  CD2 . LEU A 1 37  ? 7.399  -74.509 9.427   1    43.75  ? 36   LEU A CD2 1 
ATOM   256  N  N   . LEU A 1 38  ? 10.024 -70.777 10.119  1    38.11  ? 37   LEU A N   1 
ATOM   257  C  CA  . LEU A 1 38  ? 10.782 -70.179 9.029   1    37.73  ? 37   LEU A CA  1 
ATOM   258  C  C   . LEU A 1 38  ? 12.051 -69.517 9.516   1    37.87  ? 37   LEU A C   1 
ATOM   259  O  O   . LEU A 1 38  ? 13.062 -69.564 8.806   1    37.84  ? 37   LEU A O   1 
ATOM   260  C  CB  . LEU A 1 38  ? 9.912  -69.207 8.22    1    37.79  ? 37   LEU A CB  1 
ATOM   261  C  CG  . LEU A 1 38  ? 8.657  -69.815 7.597   1    39.28  ? 37   LEU A CG  1 
ATOM   262  C  CD1 . LEU A 1 38  ? 7.966  -68.808 6.704   1    39.91  ? 37   LEU A CD1 1 
ATOM   263  C  CD2 . LEU A 1 38  ? 8.967  -71.068 6.763   1    40.5   ? 37   LEU A CD2 1 
ATOM   264  N  N   . ASN A 1 39  ? 12.04  -68.944 10.738  1    37.62  ? 38   ASN A N   1 
ATOM   265  C  CA  . ASN A 1 39  ? 13.247 -68.356 11.306  1    38.27  ? 38   ASN A CA  1 
ATOM   266  C  C   . ASN A 1 39  ? 14.278 -69.459 11.639  1    38.53  ? 38   ASN A C   1 
ATOM   267  O  O   . ASN A 1 39  ? 15.485 -69.232 11.484  1    38.74  ? 38   ASN A O   1 
ATOM   268  C  CB  . ASN A 1 39  ? 12.944 -67.484 12.516  1    40.04  ? 38   ASN A CB  1 
ATOM   269  C  CG  . ASN A 1 39  ? 12.754 -66.017 12.178  1    45.29  ? 38   ASN A CG  1 
ATOM   270  O  OD1 . ASN A 1 39  ? 13.586 -65.39  11.512  1    47.95  ? 38   ASN A OD1 1 
ATOM   271  N  ND2 . ASN A 1 39  ? 11.671 -65.414 12.645  1    45.31  ? 38   ASN A ND2 1 
ATOM   272  N  N   . ASP A 1 40  ? 13.813 -70.653 12.05   1    37.41  ? 39   ASP A N   1 
ATOM   273  C  CA  . ASP A 1 40  ? 14.717 -71.774 12.345  1    37.5   ? 39   ASP A CA  1 
ATOM   274  C  C   . ASP A 1 40  ? 15.343 -72.284 11.027  1    36.76  ? 39   ASP A C   1 
ATOM   275  O  O   . ASP A 1 40  ? 16.515 -72.645 11.001  1    36.81  ? 39   ASP A O   1 
ATOM   276  C  CB  . ASP A 1 40  ? 13.971 -72.94  13.009  1    39.55  ? 39   ASP A CB  1 
ATOM   277  C  CG  . ASP A 1 40  ? 13.322 -72.601 14.339  1    45.49  ? 39   ASP A CG  1 
ATOM   278  O  OD1 . ASP A 1 40  ? 13.77  -71.624 14.997  1    46.31  ? 39   ASP A OD1 1 
ATOM   279  O  OD2 . ASP A 1 40  ? 12.36  -73.304 14.724  1    48.41  ? 39   ASP A OD2 1 
ATOM   280  N  N   . ALA A 1 41  ? 14.548 -72.337 9.95    1    35.91  ? 40   ALA A N   1 
ATOM   281  C  CA  . ALA A 1 41  ? 15.053 -72.776 8.65    1    35.55  ? 40   ALA A CA  1 
ATOM   282  C  C   . ALA A 1 41  ? 16.087 -71.778 8.121   1    35.07  ? 40   ALA A C   1 
ATOM   283  O  O   . ALA A 1 41  ? 17.056 -72.189 7.508   1    35.53  ? 40   ALA A O   1 
ATOM   284  C  CB  . ALA A 1 41  ? 13.909 -72.902 7.669   1    36.05  ? 40   ALA A CB  1 
ATOM   285  N  N   . PHE A 1 42  ? 15.885 -70.475 8.378   1    34.03  ? 41   PHE A N   1 
ATOM   286  C  CA  . PHE A 1 42  ? 16.776 -69.424 7.926   1    33.67  ? 41   PHE A CA  1 
ATOM   287  C  C   . PHE A 1 42  ? 18.146 -69.523 8.61    1    34.5   ? 41   PHE A C   1 
ATOM   288  O  O   . PHE A 1 42  ? 19.178 -69.387 7.944   1    33.77  ? 41   PHE A O   1 
ATOM   289  C  CB  . PHE A 1 42  ? 16.132 -68.066 8.188   1    32.86  ? 41   PHE A CB  1 
ATOM   290  C  CG  . PHE A 1 42  ? 16.89  -66.888 7.643   1    33.13  ? 41   PHE A CG  1 
ATOM   291  C  CD1 . PHE A 1 42  ? 16.809 -66.555 6.303   1    33.44  ? 41   PHE A CD1 1 
ATOM   292  C  CD2 . PHE A 1 42  ? 17.634 -66.077 8.478   1    33.84  ? 41   PHE A CD2 1 
ATOM   293  C  CE1 . PHE A 1 42  ? 17.477 -65.448 5.804   1    33.93  ? 41   PHE A CE1 1 
ATOM   294  C  CE2 . PHE A 1 42  ? 18.281 -64.948 7.98    1    34.74  ? 41   PHE A CE2 1 
ATOM   295  C  CZ  . PHE A 1 42  ? 18.215 -64.657 6.64    1    34.07  ? 41   PHE A CZ  1 
ATOM   296  N  N   . GLN A 1 43  ? 18.164 -69.81  9.923   1    34.66  ? 42   GLN A N   1 
ATOM   297  C  CA  . GLN A 1 43  ? 19.436 -69.899 10.645  1    35.69  ? 42   GLN A CA  1 
ATOM   298  C  C   . GLN A 1 43  ? 19.976 -71.328 10.791  1    35.97  ? 42   GLN A C   1 
ATOM   299  O  O   . GLN A 1 43  ? 21.008 -71.514 11.437  1    36.22  ? 42   GLN A O   1 
ATOM   300  C  CB  . GLN A 1 43  ? 19.341 -69.191 12.007  1    39.06  ? 42   GLN A CB  1 
ATOM   301  C  CG  . GLN A 1 43  ? 18.425 -69.888 12.994  1    46.54  ? 42   GLN A CG  1 
ATOM   302  C  CD  . GLN A 1 43  ? 17.834 -68.949 14.035  1    55.88  ? 42   GLN A CD  1 
ATOM   303  O  OE1 . GLN A 1 43  ? 18.234 -67.774 14.166  1    59.06  ? 42   GLN A OE1 1 
ATOM   304  N  NE2 . GLN A 1 43  ? 16.842 -69.444 14.787  1    56.84  ? 42   GLN A NE2 1 
ATOM   305  N  N   . LYS A 1 44  ? 19.355 -72.307 10.132  1    36.12  ? 43   LYS A N   1 
ATOM   306  C  CA  . LYS A 1 44  ? 19.787 -73.695 10.184  1    37.58  ? 43   LYS A CA  1 
ATOM   307  C  C   . LYS A 1 44  ? 21.277 -73.896 9.857   1    38.55  ? 43   LYS A C   1 
ATOM   308  O  O   . LYS A 1 44  ? 21.778 -73.353 8.873   1    37.48  ? 43   LYS A O   1 
ATOM   309  C  CB  . LYS A 1 44  ? 18.901 -74.571 9.3     1    39.56  ? 43   LYS A CB  1 
ATOM   310  C  CG  . LYS A 1 44  ? 19.013 -76.069 9.602   1    44.18  ? 43   LYS A CG  1 
ATOM   311  C  CD  . LYS A 1 44  ? 17.652 -76.737 9.543   1    49.4   ? 43   LYS A CD  1 
ATOM   312  C  CE  . LYS A 1 44  ? 17.726 -78.222 9.302   1    54.32  ? 43   LYS A CE  1 
ATOM   313  N  NZ  . LYS A 1 44  ? 18.57  -78.899 10.323  1    58.19  ? 43   LYS A NZ  1 
ATOM   314  N  N   . GLY A 1 45  ? 21.976 -74.637 10.718  1    39.21  ? 44   GLY A N   1 
ATOM   315  C  CA  . GLY A 1 45  ? 23.396 -74.923 10.531  1    40.2   ? 44   GLY A CA  1 
ATOM   316  C  C   . GLY A 1 45  ? 24.352 -73.926 11.154  1    41.56  ? 44   GLY A C   1 
ATOM   317  O  O   . GLY A 1 45  ? 25.563 -74.165 11.191  1    41.88  ? 44   GLY A O   1 
ATOM   318  N  N   . GLY A 1 46  ? 23.833 -72.782 11.587  1    42.31  ? 45   GLY A N   1 
ATOM   319  C  CA  . GLY A 1 46  ? 24.635 -71.729 12.202  1    43.62  ? 45   GLY A CA  1 
ATOM   320  C  C   . GLY A 1 46  ? 25.778 -71.262 11.322  1    44.59  ? 45   GLY A C   1 
ATOM   321  O  O   . GLY A 1 46  ? 25.61  -71.125 10.108  1    43.82  ? 45   GLY A O   1 
ATOM   322  N  N   . PRO A 1 47  ? 26.988 -71.134 11.912  1    45.43  ? 46   PRO A N   1 
ATOM   323  C  CA  . PRO A 1 47  ? 28.158 -70.68  11.128  1    45.36  ? 46   PRO A CA  1 
ATOM   324  C  C   . PRO A 1 47  ? 28.517 -71.537 9.914   1    45.19  ? 46   PRO A C   1 
ATOM   325  O  O   . PRO A 1 47  ? 29.18  -71.065 8.994   1    45.88  ? 46   PRO A O   1 
ATOM   326  C  CB  . PRO A 1 47  ? 29.297 -70.674 12.159  1    46.51  ? 46   PRO A CB  1 
ATOM   327  C  CG  . PRO A 1 47  ? 28.614 -70.572 13.502  1    47.22  ? 46   PRO A CG  1 
ATOM   328  C  CD  . PRO A 1 47  ? 27.306 -71.288 13.349  1    45.41  ? 46   PRO A CD  1 
ATOM   329  N  N   . GLU A 1 48  ? 28.047 -72.777 9.884   1    44.21  ? 47   GLU A N   1 
ATOM   330  C  CA  . GLU A 1 48  ? 28.308 -73.703 8.79    1    43.86  ? 47   GLU A CA  1 
ATOM   331  C  C   . GLU A 1 48  ? 27.115 -73.884 7.813   1    41.96  ? 47   GLU A C   1 
ATOM   332  O  O   . GLU A 1 48  ? 27.241 -74.588 6.814   1    42.53  ? 47   GLU A O   1 
ATOM   333  C  CB  . GLU A 1 48  ? 28.729 -75.075 9.366   1    47.67  ? 47   GLU A CB  1 
ATOM   334  C  CG  . GLU A 1 48  ? 30.01  -75.037 10.194  1    54.39  ? 47   GLU A CG  1 
ATOM   335  C  CD  . GLU A 1 48  ? 29.832 -74.719 11.667  1    63.68  ? 47   GLU A CD  1 
ATOM   336  O  OE1 . GLU A 1 48  ? 30.831 -74.325 12.314  1    67.24  ? 47   GLU A OE1 1 
ATOM   337  O  OE2 . GLU A 1 48  ? 28.696 -74.858 12.177  1    65.98  ? 47   GLU A OE2 1 
ATOM   338  N  N   . GLY A 1 49  ? 25.985 -73.236 8.086   1    39.34  ? 48   GLY A N   1 
ATOM   339  C  CA  . GLY A 1 49  ? 24.791 -73.377 7.264   1    37.13  ? 48   GLY A CA  1 
ATOM   340  C  C   . GLY A 1 49  ? 24.74  -72.498 6.03    1    35     ? 48   GLY A C   1 
ATOM   341  O  O   . GLY A 1 49  ? 25.614 -71.654 5.816   1    34.85  ? 48   GLY A O   1 
ATOM   342  N  N   . ALA A 1 50  ? 23.703 -72.704 5.216   1    33.2   ? 49   ALA A N   1 
ATOM   343  C  CA  . ALA A 1 50  ? 23.501 -72.003 3.953   1    32.05  ? 49   ALA A CA  1 
ATOM   344  C  C   . ALA A 1 50  ? 23.463 -70.48  4.066   1    30.78  ? 49   ALA A C   1 
ATOM   345  O  O   . ALA A 1 50  ? 24.072 -69.786 3.235   1    30.27  ? 49   ALA A O   1 
ATOM   346  C  CB  . ALA A 1 50  ? 22.241 -72.513 3.269   1    31.98  ? 49   ALA A CB  1 
ATOM   347  N  N   . THR A 1 51  ? 22.763 -69.945 5.086   1    29.63  ? 50   THR A N   1 
ATOM   348  C  CA  . THR A 1 51  ? 22.648 -68.494 5.223   1    28.21  ? 50   THR A CA  1 
ATOM   349  C  C   . THR A 1 51  ? 23.977 -67.823 5.554   1    28.52  ? 50   THR A C   1 
ATOM   350  O  O   . THR A 1 51  ? 24.24  -66.722 5.044   1    27.51  ? 50   THR A O   1 
ATOM   351  C  CB  . THR A 1 51  ? 21.524 -68.139 6.199   1    28.11  ? 50   THR A CB  1 
ATOM   352  O  OG1 . THR A 1 51  ? 20.339 -68.74  5.693   1    27.54  ? 50   THR A OG1 1 
ATOM   353  C  CG2 . THR A 1 51  ? 21.326 -66.674 6.331   1    28.2   ? 50   THR A CG2 1 
ATOM   354  N  N   . THR A 1 52  ? 24.867 -68.487 6.329   1    28.33  ? 51   THR A N   1 
ATOM   355  C  CA  . THR A 1 52  ? 26.18  -67.881 6.601   1    28.81  ? 51   THR A CA  1 
ATOM   356  C  C   . THR A 1 52  ? 27.026 -67.86  5.308   1    27.62  ? 51   THR A C   1 
ATOM   357  O  O   . THR A 1 52  ? 27.703 -66.859 5.038   1    27.1   ? 51   THR A O   1 
ATOM   358  C  CB  . THR A 1 52  ? 26.876 -68.572 7.786   1    30.85  ? 51   THR A CB  1 
ATOM   359  O  OG1 . THR A 1 52  ? 26.039 -68.399 8.946   1    31.21  ? 51   THR A OG1 1 
ATOM   360  C  CG2 . THR A 1 52  ? 28.243 -67.981 8.066   1    31.51  ? 51   THR A CG2 1 
ATOM   361  N  N   . ARG A 1 53  ? 26.941 -68.923 4.511   1    27.9   ? 52   ARG A N   1 
ATOM   362  C  CA  . ARG A 1 53  ? 27.647 -69.013 3.213   1    28.84  ? 52   ARG A CA  1 
ATOM   363  C  C   . ARG A 1 53  ? 27.159 -67.866 2.29    1    28.73  ? 52   ARG A C   1 
ATOM   364  O  O   . ARG A 1 53  ? 27.965 -67.168 1.68    1    28.85  ? 52   ARG A O   1 
ATOM   365  C  CB  . ARG A 1 53  ? 27.372 -70.36  2.546   1    31.72  ? 52   ARG A CB  1 
ATOM   366  C  CG  . ARG A 1 53  ? 27.993 -71.552 3.299   1    36.84  ? 52   ARG A CG  1 
ATOM   367  C  CD  . ARG A 1 53  ? 27.73  -72.845 2.531   1    42.05  ? 52   ARG A CD  1 
ATOM   368  N  NE  . ARG A 1 53  ? 28.528 -72.889 1.309   1    46.11  ? 52   ARG A NE  1 
ATOM   369  C  CZ  . ARG A 1 53  ? 28.135 -73.439 0.166   1    49.73  ? 52   ARG A CZ  1 
ATOM   370  N  NH1 . ARG A 1 53  ? 26.926 -73.98  0.062   1    49.46  ? 52   ARG A NH1 1 
ATOM   371  N  NH2 . ARG A 1 53  ? 28.941 -73.438 -0.889  1    50.49  ? 52   ARG A NH2 1 
ATOM   372  N  N   . LEU A 1 54  ? 25.845 -67.649 2.243   1    27.45  ? 53   LEU A N   1 
ATOM   373  C  CA  . LEU A 1 54  ? 25.244 -66.549 1.498   1    26.88  ? 53   LEU A CA  1 
ATOM   374  C  C   . LEU A 1 54  ? 25.797 -65.181 1.999   1    26.45  ? 53   LEU A C   1 
ATOM   375  O  O   . LEU A 1 54  ? 26.27  -64.369 1.193   1    25.77  ? 53   LEU A O   1 
ATOM   376  C  CB  . LEU A 1 54  ? 23.704 -66.599 1.681   1    26.7   ? 53   LEU A CB  1 
ATOM   377  C  CG  . LEU A 1 54  ? 22.959 -65.428 1.039   1    28.05  ? 53   LEU A CG  1 
ATOM   378  C  CD1 . LEU A 1 54  ? 23.049 -65.537 -0.461  1    28.74  ? 53   LEU A CD1 1 
ATOM   379  C  CD2 . LEU A 1 54  ? 21.5   -65.377 1.518   1    28.65  ? 53   LEU A CD2 1 
ATOM   380  N  N   . MET A 1 55  ? 25.748 -64.92  3.326   1    25.35  ? 54   MET A N   1 
ATOM   381  C  CA  . MET A 1 55  ? 26.174 -63.643 3.866   1    25.48  ? 54   MET A CA  1 
ATOM   382  C  C   . MET A 1 55  ? 27.675 -63.388 3.723   1    26.34  ? 54   MET A C   1 
ATOM   383  O  O   . MET A 1 55  ? 28.092 -62.231 3.702   1    26.47  ? 54   MET A O   1 
ATOM   384  C  CB  . MET A 1 55  ? 25.711 -63.446 5.314   1    26.03  ? 54   MET A CB  1 
ATOM   385  C  CG  . MET A 1 55  ? 24.207 -63.516 5.486   1    29.02  ? 54   MET A CG  1 
ATOM   386  S  SD  . MET A 1 55  ? 23.305 -62.162 4.677   1    36.03  ? 54   MET A SD  1 
ATOM   387  C  CE  . MET A 1 55  ? 21.72  -62.306 5.561   1    39.45  ? 54   MET A CE  1 
ATOM   388  N  N   . LYS A 1 56  ? 28.487 -64.451 3.627   1    26.02  ? 55   LYS A N   1 
ATOM   389  C  CA  . LYS A 1 56  ? 29.931 -64.278 3.421   1    26.04  ? 55   LYS A CA  1 
ATOM   390  C  C   . LYS A 1 56  ? 30.28  -64.153 1.911   1    27.01  ? 55   LYS A C   1 
ATOM   391  O  O   . LYS A 1 56  ? 31.45  -63.979 1.586   1    28.34  ? 55   LYS A O   1 
ATOM   392  C  CB  . LYS A 1 56  ? 30.709 -65.45  4.01    1    27.47  ? 55   LYS A CB  1 
ATOM   393  C  CG  . LYS A 1 56  ? 30.785 -65.431 5.522   1    32.22  ? 55   LYS A CG  1 
ATOM   394  C  CD  . LYS A 1 56  ? 31.529 -66.654 6.059   1    37.95  ? 55   LYS A CD  1 
ATOM   395  C  CE  . LYS A 1 56  ? 31.917 -66.392 7.489   1    43.15  ? 55   LYS A CE  1 
ATOM   396  N  NZ  . LYS A 1 56  ? 32.689 -67.519 8.078   1    46.02  ? 55   LYS A NZ  1 
ATOM   397  N  N   . GLY A 1 57  ? 29.303 -64.271 1.019   1    26.85  ? 56   GLY A N   1 
ATOM   398  C  CA  . GLY A 1 57  ? 29.545 -64.144 -0.409  1    27.87  ? 56   GLY A CA  1 
ATOM   399  C  C   . GLY A 1 57  ? 30.046 -65.421 -1.054  1    27.93  ? 56   GLY A C   1 
ATOM   400  O  O   . GLY A 1 57  ? 30.517 -65.37  -2.182  1    28.2   ? 56   GLY A O   1 
ATOM   401  N  N   . GLU A 1 58  ? 29.933 -66.582 -0.372  1    27.22  ? 57   GLU A N   1 
ATOM   402  C  CA  . GLU A 1 58  ? 30.367 -67.84  -0.958  1    27.6   ? 57   GLU A CA  1 
ATOM   403  C  C   . GLU A 1 58  ? 29.452 -68.262 -2.093  1    27.42  ? 57   GLU A C   1 
ATOM   404  O  O   . GLU A 1 58  ? 29.915 -68.865 -3.054  1    27.96  ? 57   GLU A O   1 
ATOM   405  C  CB  . GLU A 1 58  ? 30.408 -68.954 0.106   1    30.33  ? 57   GLU A CB  1 
ATOM   406  C  CG  . GLU A 1 58  ? 31.389 -68.631 1.204   1    37.72  ? 57   GLU A CG  1 
ATOM   407  C  CD  . GLU A 1 58  ? 31.466 -69.686 2.285   1    45.19  ? 57   GLU A CD  1 
ATOM   408  O  OE1 . GLU A 1 58  ? 31.14  -70.862 1.997   1    46.63  ? 57   GLU A OE1 1 
ATOM   409  O  OE2 . GLU A 1 58  ? 31.877 -69.338 3.416   1    48.3   ? 57   GLU A OE2 1 
ATOM   410  N  N   . ILE A 1 59  ? 28.139 -67.985 -1.966  1    26.56  ? 58   ILE A N   1 
ATOM   411  C  CA  . ILE A 1 59  ? 27.118 -68.284 -2.957  1    26.78  ? 58   ILE A CA  1 
ATOM   412  C  C   . ILE A 1 59  ? 26.24  -67.03  -3.14   1    26.3   ? 58   ILE A C   1 
ATOM   413  O  O   . ILE A 1 59  ? 26.268 -66.122 -2.299  1    27.27  ? 58   ILE A O   1 
ATOM   414  C  CB  . ILE A 1 59  ? 26.247 -69.511 -2.521  1    27.66  ? 58   ILE A CB  1 
ATOM   415  C  CG1 . ILE A 1 59  ? 25.481 -69.199 -1.21   1    27.94  ? 58   ILE A CG1 1 
ATOM   416  C  CG2 . ILE A 1 59  ? 27.123 -70.781 -2.376  1    28.51  ? 58   ILE A CG2 1 
ATOM   417  C  CD1 . ILE A 1 59  ? 24.509 -70.345 -0.748  1    29.58  ? 58   ILE A CD1 1 
ATOM   418  N  N   . THR A 1 60  ? 25.457 -66.993 -4.227  1    26.2   ? 59   THR A N   1 
ATOM   419  C  CA  . THR A 1 60  ? 24.558 -65.866 -4.478  1    26.69  ? 59   THR A CA  1 
ATOM   420  C  C   . THR A 1 60  ? 23.141 -66.13  -3.908  1    26.67  ? 59   THR A C   1 
ATOM   421  O  O   . THR A 1 60  ? 22.817 -67.277 -3.585  1    26.88  ? 59   THR A O   1 
ATOM   422  C  CB  . THR A 1 60  ? 24.445 -65.633 -6.011  1    27.83  ? 59   THR A CB  1 
ATOM   423  O  OG1 . THR A 1 60  ? 23.688 -66.695 -6.587  1    29     ? 59   THR A OG1 1 
ATOM   424  C  CG2 . THR A 1 60  ? 25.806 -65.502 -6.705  1    27.78  ? 59   THR A CG2 1 
ATOM   425  N  N   . LEU A 1 61  ? 22.271 -65.101 -3.886  1    26.56  ? 60   LEU A N   1 
ATOM   426  C  CA  . LEU A 1 61  ? 20.891 -65.277 -3.412  1    27.65  ? 60   LEU A CA  1 
ATOM   427  C  C   . LEU A 1 61  ? 20.124 -66.361 -4.171  1    28.49  ? 60   LEU A C   1 
ATOM   428  O  O   . LEU A 1 61  ? 19.462 -67.197 -3.537  1    29.15  ? 60   LEU A O   1 
ATOM   429  C  CB  . LEU A 1 61  ? 20.139 -63.952 -3.496  1    28.26  ? 60   LEU A CB  1 
ATOM   430  C  CG  . LEU A 1 61  ? 18.795 -63.893 -2.758  1    29.26  ? 60   LEU A CG  1 
ATOM   431  C  CD1 . LEU A 1 61  ? 18.956 -64.264 -1.27   1    29.16  ? 60   LEU A CD1 1 
ATOM   432  C  CD2 . LEU A 1 61  ? 18.245 -62.471 -2.814  1    30.41  ? 60   LEU A CD2 1 
ATOM   433  N  N   . SER A 1 62  ? 20.238 -66.406 -5.517  1    27.48  ? 61   SER A N   1 
ATOM   434  C  CA  . SER A 1 62  ? 19.523 -67.409 -6.297  1    28.05  ? 61   SER A CA  1 
ATOM   435  C  C   . SER A 1 62  ? 20.006 -68.813 -6.027  1    28.89  ? 61   SER A C   1 
ATOM   436  O  O   . SER A 1 62  ? 19.208 -69.741 -6.107  1    30.25  ? 61   SER A O   1 
ATOM   437  C  CB  . SER A 1 62  ? 19.546 -67.097 -7.792  1    29.19  ? 61   SER A CB  1 
ATOM   438  O  OG  . SER A 1 62  ? 18.917 -65.849 -8.026  1    31.08  ? 61   SER A OG  1 
ATOM   439  N  N   . GLN A 1 63  ? 21.294 -68.991 -5.718  1    28.09  ? 62   GLN A N   1 
ATOM   440  C  CA  . GLN A 1 63  ? 21.782 -70.319 -5.341  1    27.42  ? 62   GLN A CA  1 
ATOM   441  C  C   . GLN A 1 63  ? 21.242 -70.692 -3.922  1    28.23  ? 62   GLN A C   1 
ATOM   442  O  O   . GLN A 1 63  ? 21.077 -71.874 -3.634  1    28.95  ? 62   GLN A O   1 
ATOM   443  C  CB  . GLN A 1 63  ? 23.312 -70.339 -5.293  1    28.57  ? 62   GLN A CB  1 
ATOM   444  C  CG  . GLN A 1 63  ? 23.963 -70.165 -6.65   1    28.28  ? 62   GLN A CG  1 
ATOM   445  C  CD  . GLN A 1 63  ? 25.463 -70.162 -6.468  1    28.64  ? 62   GLN A CD  1 
ATOM   446  O  OE1 . GLN A 1 63  ? 26.044 -69.158 -6.064  1    28.92  ? 62   GLN A OE1 1 
ATOM   447  N  NE2 . GLN A 1 63  ? 26.114 -71.293 -6.715  1    28.28  ? 62   GLN A NE2 1 
ATOM   448  N  N   . TRP A 1 64  ? 21.069 -69.707 -3.039  1    27.92  ? 63   TRP A N   1 
ATOM   449  C  CA  . TRP A 1 64  ? 20.637 -69.943 -1.656  1    29.43  ? 63   TRP A CA  1 
ATOM   450  C  C   . TRP A 1 64  ? 19.158 -70.28  -1.577  1    31.15  ? 63   TRP A C   1 
ATOM   451  O  O   . TRP A 1 64  ? 18.768 -71.104 -0.746  1    31.66  ? 63   TRP A O   1 
ATOM   452  C  CB  . TRP A 1 64  ? 20.968 -68.727 -0.78   1    29.21  ? 63   TRP A CB  1 
ATOM   453  C  CG  . TRP A 1 64  ? 20.39  -68.74  0.615   1    30.15  ? 63   TRP A CG  1 
ATOM   454  C  CD1 . TRP A 1 64  ? 21.001 -69.173 1.761   1    31.64  ? 63   TRP A CD1 1 
ATOM   455  C  CD2 . TRP A 1 64  ? 19.128 -68.185 1.016   1    30.47  ? 63   TRP A CD2 1 
ATOM   456  N  NE1 . TRP A 1 64  ? 20.194 -68.913 2.856   1    31.34  ? 63   TRP A NE1 1 
ATOM   457  C  CE2 . TRP A 1 64  ? 19.045 -68.297 2.424   1    31.17  ? 63   TRP A CE2 1 
ATOM   458  C  CE3 . TRP A 1 64  ? 18.07  -67.578 0.32    1    30.8   ? 63   TRP A CE3 1 
ATOM   459  C  CZ2 . TRP A 1 64  ? 17.936 -67.842 3.143   1    32.15  ? 63   TRP A CZ2 1 
ATOM   460  C  CZ3 . TRP A 1 64  ? 16.983 -67.105 1.038   1    32.09  ? 63   TRP A CZ3 1 
ATOM   461  C  CH2 . TRP A 1 64  ? 16.921 -67.244 2.431   1    32.36  ? 63   TRP A CH2 1 
ATOM   462  N  N   . ILE A 1 65  ? 18.332 -69.691 -2.454  1    31.94  ? 64   ILE A N   1 
ATOM   463  C  CA  . ILE A 1 65  ? 16.868 -69.904 -2.417  1    32.9   ? 64   ILE A CA  1 
ATOM   464  C  C   . ILE A 1 65  ? 16.476 -71.417 -2.32   1    33.89  ? 64   ILE A C   1 
ATOM   465  O  O   . ILE A 1 65  ? 15.765 -71.743 -1.358  1    33.94  ? 64   ILE A O   1 
ATOM   466  C  CB  . ILE A 1 65  ? 16.129 -69.136 -3.55   1    33.17  ? 64   ILE A CB  1 
ATOM   467  C  CG1 . ILE A 1 65  ? 16.153 -67.633 -3.227  1    34.11  ? 64   ILE A CG1 1 
ATOM   468  C  CG2 . ILE A 1 65  ? 14.679 -69.623 -3.696  1    34.3   ? 64   ILE A CG2 1 
ATOM   469  C  CD1 . ILE A 1 65  ? 15.586 -66.71  -4.319  1    36.2   ? 64   ILE A CD1 1 
ATOM   470  N  N   . PRO A 1 66  ? 16.984 -72.358 -3.16   1    34.4   ? 65   PRO A N   1 
ATOM   471  C  CA  . PRO A 1 66  ? 16.618 -73.775 -2.969  1    34.06  ? 65   PRO A CA  1 
ATOM   472  C  C   . PRO A 1 66  ? 17.172 -74.406 -1.678  1    34.08  ? 65   PRO A C   1 
ATOM   473  O  O   . PRO A 1 66  ? 16.557 -75.34  -1.16   1    34.6   ? 65   PRO A O   1 
ATOM   474  C  CB  . PRO A 1 66  ? 17.147 -74.448 -4.231  1    35.19  ? 65   PRO A CB  1 
ATOM   475  C  CG  . PRO A 1 66  ? 18.286 -73.584 -4.674  1    35.38  ? 65   PRO A CG  1 
ATOM   476  C  CD  . PRO A 1 66  ? 17.839 -72.185 -4.357  1    33.76  ? 65   PRO A CD  1 
ATOM   477  N  N   . LEU A 1 67  ? 18.317 -73.918 -1.144  1    32.61  ? 66   LEU A N   1 
ATOM   478  C  CA  . LEU A 1 67  ? 18.861 -74.434 0.123   1    32.75  ? 66   LEU A CA  1 
ATOM   479  C  C   . LEU A 1 67  ? 17.935 -74.02  1.279   1    33.16  ? 66   LEU A C   1 
ATOM   480  O  O   . LEU A 1 67  ? 17.681 -74.816 2.19    1    33.2   ? 66   LEU A O   1 
ATOM   481  C  CB  . LEU A 1 67  ? 20.272 -73.896 0.396   1    33.06  ? 66   LEU A CB  1 
ATOM   482  C  CG  . LEU A 1 67  ? 21.277 -74.067 -0.743  1    35.16  ? 66   LEU A CG  1 
ATOM   483  C  CD1 . LEU A 1 67  ? 22.631 -73.462 -0.36   1    35.6   ? 66   LEU A CD1 1 
ATOM   484  C  CD2 . LEU A 1 67  ? 21.448 -75.544 -1.107  1    36.19  ? 66   LEU A CD2 1 
ATOM   485  N  N   . MET A 1 68  ? 17.417 -72.778 1.235   1    32.4   ? 67   MET A N   1 
ATOM   486  C  CA  . MET A 1 68  ? 16.495 -72.29  2.26    1    33.01  ? 67   MET A CA  1 
ATOM   487  C  C   . MET A 1 68  ? 15.206 -73.113 2.199   1    35.29  ? 67   MET A C   1 
ATOM   488  O  O   . MET A 1 68  ? 14.701 -73.532 3.246   1    35.84  ? 67   MET A O   1 
ATOM   489  C  CB  . MET A 1 68  ? 16.192 -70.798 2.043   1    32.81  ? 67   MET A CB  1 
ATOM   490  C  CG  . MET A 1 68  ? 15.033 -70.278 2.88    1    33.3   ? 67   MET A CG  1 
ATOM   491  S  SD  . MET A 1 68  ? 15.356 -70.42  4.658   1    35.68  ? 67   MET A SD  1 
ATOM   492  C  CE  . MET A 1 68  ? 13.874 -69.527 5.308   1    35.6   ? 67   MET A CE  1 
ATOM   493  N  N   . GLU A 1 69  ? 14.709 -73.392 0.981   1    36.8   ? 68   GLU A N   1 
ATOM   494  C  CA  . GLU A 1 69  ? 13.505 -74.198 0.791   1    39.09  ? 68   GLU A CA  1 
ATOM   495  C  C   . GLU A 1 69  ? 13.665 -75.594 1.349   1    41.31  ? 68   GLU A C   1 
ATOM   496  O  O   . GLU A 1 69  ? 12.736 -76.097 1.985   1    42.18  ? 68   GLU A O   1 
ATOM   497  C  CB  . GLU A 1 69  ? 13.127 -74.271 -0.683  1    41.65  ? 68   GLU A CB  1 
ATOM   498  C  CG  . GLU A 1 69  ? 12.57  -72.958 -1.18   1    47.5   ? 68   GLU A CG  1 
ATOM   499  C  CD  . GLU A 1 69  ? 12.213 -72.935 -2.65   1    55.62  ? 68   GLU A CD  1 
ATOM   500  O  OE1 . GLU A 1 69  ? 12.928 -73.582 -3.45   1    55.75  ? 68   GLU A OE1 1 
ATOM   501  O  OE2 . GLU A 1 69  ? 11.227 -72.247 -3.002  1    59.48  ? 68   GLU A OE2 1 
ATOM   502  N  N   . GLU A 1 70  ? 14.844 -76.216 1.161   1    41.6   ? 69   GLU A N   1 
ATOM   503  C  CA  . GLU A 1 70  ? 15.094 -77.544 1.717   1    42.48  ? 69   GLU A CA  1 
ATOM   504  C  C   . GLU A 1 70  ? 15.097 -77.466 3.25    1    43.22  ? 69   GLU A C   1 
ATOM   505  O  O   . GLU A 1 70  ? 14.479 -78.313 3.901   1    44.17  ? 69   GLU A O   1 
ATOM   506  C  CB  . GLU A 1 70  ? 16.403 -78.151 1.145   1    46.15  ? 69   GLU A CB  1 
ATOM   507  C  CG  . GLU A 1 70  ? 17.036 -79.288 1.943   1    53.58  ? 69   GLU A CG  1 
ATOM   508  C  CD  . GLU A 1 70  ? 16.289 -80.614 1.955   1    65.19  ? 69   GLU A CD  1 
ATOM   509  O  OE1 . GLU A 1 70  ? 16.775 -81.56  2.62    1    67.27  ? 69   GLU A OE1 1 
ATOM   510  O  OE2 . GLU A 1 70  ? 15.221 -80.71  1.302   1    68.62  ? 69   GLU A OE2 1 
ATOM   511  N  N   . ASN A 1 71  ? 15.696 -76.408 3.82    1    42.27  ? 70   ASN A N   1 
ATOM   512  C  CA  . ASN A 1 71  ? 15.723 -76.206 5.266   1    42.43  ? 70   ASN A CA  1 
ATOM   513  C  C   . ASN A 1 71  ? 14.31  -76.024 5.833   1    43.25  ? 70   ASN A C   1 
ATOM   514  O  O   . ASN A 1 71  ? 14.033 -76.48  6.945   1    43.84  ? 70   ASN A O   1 
ATOM   515  C  CB  . ASN A 1 71  ? 16.594 -75.008 5.63    1    42.03  ? 70   ASN A CB  1 
ATOM   516  C  CG  . ASN A 1 71  ? 18.075 -75.259 5.473   1    43.31  ? 70   ASN A CG  1 
ATOM   517  O  OD1 . ASN A 1 71  ? 18.518 -76.365 5.167   1    44.76  ? 70   ASN A OD1 1 
ATOM   518  N  ND2 . ASN A 1 71  ? 18.871 -74.236 5.681   1    42.4   ? 70   ASN A ND2 1 
ATOM   519  N  N   . CYS A 1 72  ? 13.424 -75.365 5.074   1    43.26  ? 71   CYS A N   1 
ATOM   520  C  CA  . CYS A 1 72  ? 12.039 -75.158 5.49    1    44.09  ? 71   CYS A CA  1 
ATOM   521  C  C   . CYS A 1 72  ? 11.309 -76.473 5.634   1    46.12  ? 71   CYS A C   1 
ATOM   522  O  O   . CYS A 1 72  ? 10.55  -76.636 6.585   1    46.22  ? 71   CYS A O   1 
ATOM   523  C  CB  . CYS A 1 72  ? 11.305 -74.202 4.553   1    43.07  ? 71   CYS A CB  1 
ATOM   524  S  SG  . CYS A 1 72  ? 11.78  -72.465 4.762   1    41.08  ? 71   CYS A SG  1 
ATOM   525  N  N   . ARG A 1 73  ? 11.575 -77.425 4.74    1    47.25  ? 72   ARG A N   1 
ATOM   526  C  CA  . ARG A 1 73  ? 10.975 -78.752 4.775   1    49.07  ? 72   ARG A CA  1 
ATOM   527  C  C   . ARG A 1 73  ? 11.537 -79.619 5.908   1    50.27  ? 72   ARG A C   1 
ATOM   528  O  O   . ARG A 1 73  ? 10.781 -80.357 6.544   1    50.76  ? 72   ARG A O   1 
ATOM   529  C  CB  . ARG A 1 73  ? 11.09  -79.422 3.409   1    51.14  ? 72   ARG A CB  1 
ATOM   530  C  CG  . ARG A 1 73  ? 10.429 -78.552 2.35    1    56.45  ? 72   ARG A CG  1 
ATOM   531  C  CD  . ARG A 1 73  ? 10.331 -79.203 0.998   1    61.66  ? 72   ARG A CD  1 
ATOM   532  N  NE  . ARG A 1 73  ? 11.621 -79.286 0.31    1    66     ? 72   ARG A NE  1 
ATOM   533  C  CZ  . ARG A 1 73  ? 11.915 -78.638 -0.815  1    69.11  ? 72   ARG A CZ  1 
ATOM   534  N  NH1 . ARG A 1 73  ? 11.013 -77.852 -1.393  1    69.11  ? 72   ARG A NH1 1 
ATOM   535  N  NH2 . ARG A 1 73  ? 13.109 -78.775 -1.373  1    68.87  ? 72   ARG A NH2 1 
ATOM   536  N  N   . LYS A 1 74  ? 12.834 -79.492 6.208   1    50.57  ? 73   LYS A N   1 
ATOM   537  C  CA  . LYS A 1 74  ? 13.437 -80.244 7.314   1    51.38  ? 73   LYS A CA  1 
ATOM   538  C  C   . LYS A 1 74  ? 12.881 -79.747 8.664   1    52.28  ? 73   LYS A C   1 
ATOM   539  O  O   . LYS A 1 74  ? 12.676 -80.549 9.57    1    52.43  ? 73   LYS A O   1 
ATOM   540  C  CB  . LYS A 1 74  ? 14.968 -80.142 7.283   1    52.93  ? 73   LYS A CB  1 
ATOM   541  N  N   . CYS A 1 75  ? 12.596 -78.437 8.779   1    52.73  ? 74   CYS A N   1 
ATOM   542  C  CA  . CYS A 1 75  ? 12.029 -77.862 9.999   1    53.66  ? 74   CYS A CA  1 
ATOM   543  C  C   . CYS A 1 75  ? 10.551 -78.248 10.136  1    55.08  ? 74   CYS A C   1 
ATOM   544  O  O   . CYS A 1 75  ? 10.102 -78.578 11.239  1    55.22  ? 74   CYS A O   1 
ATOM   545  C  CB  . CYS A 1 75  ? 12.227 -76.347 10.036  1    53.72  ? 74   CYS A CB  1 
ATOM   546  S  SG  . CYS A 1 75  ? 13.939 -75.836 10.356  1    55.42  ? 74   CYS A SG  1 
ATOM   547  N  N   A SER A 1 76  ? 9.8    -78.219 9.024   0.7  55.32  ? 75   SER A N   1 
ATOM   548  N  N   B SER A 1 76  ? 9.817  -78.225 9.011   0.3  55.42  ? 75   SER A N   1 
ATOM   549  C  CA  A SER A 1 76  ? 8.382  -78.573 9.038   0.7  56.36  ? 75   SER A CA  1 
ATOM   550  C  CA  B SER A 1 76  ? 8.398  -78.567 8.917   0.3  56.39  ? 75   SER A CA  1 
ATOM   551  C  C   A SER A 1 76  ? 8.175  -80.06  9.348   0.7  57.24  ? 75   SER A C   1 
ATOM   552  C  C   B SER A 1 76  ? 8.157  -80.04  9.266   0.3  57.21  ? 75   SER A C   1 
ATOM   553  O  O   A SER A 1 76  ? 7.207  -80.419 10.02   0.7  57.38  ? 75   SER A O   1 
ATOM   554  O  O   B SER A 1 76  ? 7.145  -80.37  9.884   0.3  57.35  ? 75   SER A O   1 
ATOM   555  C  CB  A SER A 1 76  ? 7.72   -78.208 7.711   0.7  57.84  ? 75   SER A CB  1 
ATOM   556  C  CB  B SER A 1 76  ? 7.897  -78.287 7.502   0.3  57.76  ? 75   SER A CB  1 
ATOM   557  O  OG  A SER A 1 76  ? 8.095  -79.098 6.673   0.7  60.15  ? 75   SER A OG  1 
ATOM   558  O  OG  B SER A 1 76  ? 6.487  -78.162 7.424   0.3  60     ? 75   SER A OG  1 
ATOM   559  N  N   . GLU A 1 77  ? 9.086  -80.92  8.87    1    57.56  ? 76   GLU A N   1 
ATOM   560  C  CA  . GLU A 1 77  ? 8.99   -82.355 9.134   1    58.71  ? 76   GLU A CA  1 
ATOM   561  C  C   . GLU A 1 77  ? 9.221  -82.652 10.613  1    59.83  ? 76   GLU A C   1 
ATOM   562  O  O   . GLU A 1 77  ? 8.508  -83.477 11.177  1    60.11  ? 76   GLU A O   1 
ATOM   563  C  CB  . GLU A 1 77  ? 9.984  -83.146 8.269   1    60.25  ? 76   GLU A CB  1 
ATOM   564  N  N   . THR A 1 78  ? 10.183 -81.968 11.252  1    60.41  ? 77   THR A N   1 
ATOM   565  C  CA  . THR A 1 78  ? 10.442 -82.184 12.682  1    61.6   ? 77   THR A CA  1 
ATOM   566  C  C   . THR A 1 78  ? 9.296  -81.622 13.55   1    61.87  ? 77   THR A C   1 
ATOM   567  O  O   . THR A 1 78  ? 8.987  -82.195 14.594  1    61.61  ? 77   THR A O   1 
ATOM   568  C  CB  . THR A 1 78  ? 11.831 -81.674 13.088  1    63.44  ? 77   THR A CB  1 
ATOM   569  O  OG1 . THR A 1 78  ? 11.945 -80.291 12.747  1    65.35  ? 77   THR A OG1 1 
ATOM   570  C  CG2 . THR A 1 78  ? 12.952 -82.458 12.425  1    63.7   ? 77   THR A CG2 1 
ATOM   571  N  N   . ALA A 1 79  ? 8.641  -80.536 13.089  1    61.95  ? 78   ALA A N   1 
ATOM   572  C  CA  . ALA A 1 79  ? 7.492  -79.937 13.785  1    62.54  ? 78   ALA A CA  1 
ATOM   573  C  C   . ALA A 1 79  ? 6.167  -80.687 13.516  1    63.09  ? 78   ALA A C   1 
ATOM   574  O  O   . ALA A 1 79  ? 5.164  -80.381 14.157  1    62.74  ? 78   ALA A O   1 
ATOM   575  C  CB  . ALA A 1 79  ? 7.342  -78.47  13.394  1    62.33  ? 78   ALA A CB  1 
ATOM   576  N  N   . LYS A 1 80  ? 6.164  -81.63  12.547  1    63.8   ? 79   LYS A N   1 
ATOM   577  C  CA  . LYS A 1 80  ? 5.024  -82.445 12.125  1    65.01  ? 79   LYS A CA  1 
ATOM   578  C  C   . LYS A 1 80  ? 3.924  -81.615 11.454  1    65.95  ? 79   LYS A C   1 
ATOM   579  O  O   . LYS A 1 80  ? 2.74   -81.885 11.645  1    66.14  ? 79   LYS A O   1 
ATOM   580  C  CB  . LYS A 1 80  ? 4.476  -83.308 13.279  1    66.87  ? 79   LYS A CB  1 
ATOM   581  N  N   . VAL A 1 81  ? 4.321  -80.604 10.663  1    66.38  ? 80   VAL A N   1 
ATOM   582  C  CA  . VAL A 1 81  ? 3.386  -79.717 9.958   1    67.28  ? 80   VAL A CA  1 
ATOM   583  C  C   . VAL A 1 81  ? 3.645  -79.689 8.428   1    68.01  ? 80   VAL A C   1 
ATOM   584  O  O   . VAL A 1 81  ? 4.678  -80.189 7.967   1    68.18  ? 80   VAL A O   1 
ATOM   585  C  CB  . VAL A 1 81  ? 3.446  -78.294 10.56   1    68.07  ? 80   VAL A CB  1 
ATOM   586  C  CG1 . VAL A 1 81  ? 2.951  -78.283 12      1    68.73  ? 80   VAL A CG1 1 
ATOM   587  C  CG2 . VAL A 1 81  ? 4.857  -77.728 10.453  1    68.59  ? 80   VAL A CG2 1 
ATOM   588  N  N   . CYS A 1 82  ? 2.728  -79.079 7.643   1    68.13  ? 81   CYS A N   1 
ATOM   589  C  CA  . CYS A 1 82  ? 2.917  -78.989 6.199   1    68.81  ? 81   CYS A CA  1 
ATOM   590  C  C   . CYS A 1 82  ? 2.846  -77.555 5.648   1    68.36  ? 81   CYS A C   1 
ATOM   591  O  O   . CYS A 1 82  ? 1.929  -76.798 5.972   1    68.35  ? 81   CYS A O   1 
ATOM   592  C  CB  . CYS A 1 82  ? 1.958  -79.918 5.463   1    70.56  ? 81   CYS A CB  1 
ATOM   593  S  SG  . CYS A 1 82  ? 2.68   -81.523 5.033   1    77.28  ? 81   CYS A SG  1 
ATOM   594  N  N   . LEU A 1 83  ? 3.815  -77.201 4.79    1    67.57  ? 82   LEU A N   1 
ATOM   595  C  CA  . LEU A 1 83  ? 3.882  -75.897 4.13    1    67.14  ? 82   LEU A CA  1 
ATOM   596  C  C   . LEU A 1 83  ? 2.838  -75.827 3.007   1    67.04  ? 82   LEU A C   1 
ATOM   597  O  O   . LEU A 1 83  ? 2.562  -76.842 2.362   1    67.03  ? 82   LEU A O   1 
ATOM   598  C  CB  . LEU A 1 83  ? 5.281  -75.705 3.531   1    66.95  ? 82   LEU A CB  1 
ATOM   599  C  CG  . LEU A 1 83  ? 6.432  -75.671 4.511   1    67.89  ? 82   LEU A CG  1 
ATOM   600  C  CD1 . LEU A 1 83  ? 7.751  -75.884 3.794   1    68.37  ? 82   LEU A CD1 1 
ATOM   601  C  CD2 . LEU A 1 83  ? 6.45   -74.377 5.27    1    68.33  ? 82   LEU A CD2 1 
ATOM   602  N  N   . PRO A 1 84  ? 2.277  -74.633 2.723   1    66.89  ? 83   PRO A N   1 
ATOM   603  C  CA  . PRO A 1 84  ? 1.272  -74.524 1.646   1    66.82  ? 83   PRO A CA  1 
ATOM   604  C  C   . PRO A 1 84  ? 1.73   -74.959 0.255   1    66.96  ? 83   PRO A C   1 
ATOM   605  O  O   . PRO A 1 84  ? 2.925  -74.981 -0.042  1    66.97  ? 83   PRO A O   1 
ATOM   606  C  CB  . PRO A 1 84  ? 0.898  -73.035 1.655   1    67.53  ? 83   PRO A CB  1 
ATOM   607  C  CG  . PRO A 1 84  ? 2.026  -72.354 2.358   1    67.91  ? 83   PRO A CG  1 
ATOM   608  C  CD  . PRO A 1 84  ? 2.492  -73.335 3.389   1    66.3   ? 83   PRO A CD  1 
ATOM   609  N  N   . LYS A 1 85  ? 0.753  -75.298 -0.597  1    66.82  ? 84   LYS A N   1 
ATOM   610  C  CA  . LYS A 1 85  ? 0.933  -75.762 -1.974  1    67.11  ? 84   LYS A CA  1 
ATOM   611  C  C   . LYS A 1 85  ? 1.816  -74.824 -2.821  1    66.41  ? 84   LYS A C   1 
ATOM   612  O  O   . LYS A 1 85  ? 2.768  -75.284 -3.449  1    66.86  ? 84   LYS A O   1 
ATOM   613  C  CB  . LYS A 1 85  ? -0.461 -76.007 -2.61   1    69.79  ? 84   LYS A CB  1 
ATOM   614  C  CG  . LYS A 1 85  ? -0.539 -75.978 -4.137  1    74.69  ? 84   LYS A CG  1 
ATOM   615  C  CD  . LYS A 1 85  ? 0.063  -77.206 -4.793  1    79.45  ? 84   LYS A CD  1 
ATOM   616  C  CE  . LYS A 1 85  ? 0.143  -77.015 -6.289  1    83.26  ? 84   LYS A CE  1 
ATOM   617  N  NZ  . LYS A 1 85  ? -1.153 -76.551 -6.857  1    85.49  ? 84   LYS A NZ  1 
ATOM   618  N  N   . ASN A 1 86  ? 1.519  -73.523 -2.821  1    65.14  ? 85   ASN A N   1 
ATOM   619  C  CA  . ASN A 1 86  ? 2.284  -72.56  -3.615  1    64.39  ? 85   ASN A CA  1 
ATOM   620  C  C   . ASN A 1 86  ? 3.404  -71.868 -2.82   1    62.15  ? 85   ASN A C   1 
ATOM   621  O  O   . ASN A 1 86  ? 3.766  -70.734 -3.15   1    62.57  ? 85   ASN A O   1 
ATOM   622  C  CB  . ASN A 1 86  ? 1.341  -71.511 -4.223  1    66.42  ? 85   ASN A CB  1 
ATOM   623  C  CG  . ASN A 1 86  ? 0.644  -70.65  -3.191  1    71.31  ? 85   ASN A CG  1 
ATOM   624  O  OD1 . ASN A 1 86  ? 0.332  -71.094 -2.078  1    72.99  ? 85   ASN A OD1 1 
ATOM   625  N  ND2 . ASN A 1 86  ? 0.395  -69.389 -3.535  1    72.44  ? 85   ASN A ND2 1 
ATOM   626  N  N   . PHE A 1 87  ? 3.964  -72.546 -1.79   1    59.27  ? 86   PHE A N   1 
ATOM   627  C  CA  . PHE A 1 87  ? 5.017  -71.965 -0.956  1    56.49  ? 86   PHE A CA  1 
ATOM   628  C  C   . PHE A 1 87  ? 6.245  -71.563 -1.752  1    53.4   ? 86   PHE A C   1 
ATOM   629  O  O   . PHE A 1 87  ? 6.898  -72.414 -2.373  1    53.51  ? 86   PHE A O   1 
ATOM   630  C  CB  . PHE A 1 87  ? 5.409  -72.893 0.201   1    56.21  ? 86   PHE A CB  1 
ATOM   631  C  CG  . PHE A 1 87  ? 6.363  -72.251 1.182   1    56.64  ? 86   PHE A CG  1 
ATOM   632  C  CD1 . PHE A 1 87  ? 5.935  -71.248 2.035   1    57.19  ? 86   PHE A CD1 1 
ATOM   633  C  CD2 . PHE A 1 87  ? 7.69   -72.647 1.246   1    57.3   ? 86   PHE A CD2 1 
ATOM   634  C  CE1 . PHE A 1 87  ? 6.814  -70.656 2.931   1    57.73  ? 86   PHE A CE1 1 
ATOM   635  C  CE2 . PHE A 1 87  ? 8.568  -72.05  2.142   1    57.76  ? 86   PHE A CE2 1 
ATOM   636  C  CZ  . PHE A 1 87  ? 8.127  -71.054 2.972   1    57.49  ? 86   PHE A CZ  1 
ATOM   637  N  N   . SER A 1 88  ? 6.561  -70.258 -1.736  1    49.85  ? 87   SER A N   1 
ATOM   638  C  CA  . SER A 1 88  ? 7.716  -69.773 -2.47   1    47.07  ? 87   SER A CA  1 
ATOM   639  C  C   . SER A 1 88  ? 8.577  -68.812 -1.673  1    43.5   ? 87   SER A C   1 
ATOM   640  O  O   . SER A 1 88  ? 8.158  -67.693 -1.385  1    42.52  ? 87   SER A O   1 
ATOM   641  C  CB  . SER A 1 88  ? 7.296  -69.143 -3.797  1    47.97  ? 87   SER A CB  1 
ATOM   642  O  OG  . SER A 1 88  ? 8.412  -68.587 -4.475  1    49.19  ? 87   SER A OG  1 
ATOM   643  N  N   . ILE A 1 89  ? 9.808  -69.232 -1.377  1    41.49  ? 88   ILE A N   1 
ATOM   644  C  CA  . ILE A 1 89  ? 10.785 -68.398 -0.694  1    40.26  ? 88   ILE A CA  1 
ATOM   645  C  C   . ILE A 1 89  ? 11.133 -67.202 -1.582  1    39.08  ? 88   ILE A C   1 
ATOM   646  O  O   . ILE A 1 89  ? 11.168 -66.078 -1.107  1    38.43  ? 88   ILE A O   1 
ATOM   647  C  CB  . ILE A 1 89  ? 12.031 -69.249 -0.298  1    40.74  ? 88   ILE A CB  1 
ATOM   648  C  CG1 . ILE A 1 89  ? 11.692 -70.15  0.905   1    41.06  ? 88   ILE A CG1 1 
ATOM   649  C  CG2 . ILE A 1 89  ? 13.248 -68.364 0.001   1    41.23  ? 88   ILE A CG2 1 
ATOM   650  C  CD1 . ILE A 1 89  ? 11.343 -69.346 2.184   1    42.04  ? 88   ILE A CD1 1 
ATOM   651  N  N   . LYS A 1 90  ? 11.291 -67.424 -2.894  1    39.08  ? 89   LYS A N   1 
ATOM   652  C  CA  . LYS A 1 90  ? 11.595 -66.333 -3.827  1    39.06  ? 89   LYS A CA  1 
ATOM   653  C  C   . LYS A 1 90  ? 10.498 -65.289 -3.802  1    38.34  ? 89   LYS A C   1 
ATOM   654  O  O   . LYS A 1 90  ? 10.809 -64.123 -3.625  1    38.01  ? 89   LYS A O   1 
ATOM   655  C  CB  . LYS A 1 90  ? 11.803 -66.861 -5.246  1    41.64  ? 89   LYS A CB  1 
ATOM   656  C  CG  . LYS A 1 90  ? 12.181 -65.781 -6.246  1    47.03  ? 89   LYS A CG  1 
ATOM   657  C  CD  . LYS A 1 90  ? 11.379 -65.948 -7.52   1    53.91  ? 89   LYS A CD  1 
ATOM   658  C  CE  . LYS A 1 90  ? 11.965 -65.151 -8.651  1    58.7   ? 89   LYS A CE  1 
ATOM   659  N  NZ  . LYS A 1 90  ? 12.398 -63.809 -8.194  1    61.2   ? 89   LYS A NZ  1 
ATOM   660  N  N   . GLU A 1 91  ? 9.218  -65.713 -3.826  1    38.24  ? 90   GLU A N   1 
ATOM   661  C  CA  . GLU A 1 91  ? 8.098  -64.764 -3.779  1    38.93  ? 90   GLU A CA  1 
ATOM   662  C  C   . GLU A 1 91  ? 8.061  -63.986 -2.464  1    37.8   ? 90   GLU A C   1 
ATOM   663  O  O   . GLU A 1 91  ? 7.857  -62.763 -2.462  1    37.18  ? 90   GLU A O   1 
ATOM   664  C  CB  . GLU A 1 91  ? 6.764  -65.49  -4.016  1    43.52  ? 90   GLU A CB  1 
ATOM   665  C  CG  . GLU A 1 91  ? 6.555  -65.89  -5.472  1    52.67  ? 90   GLU A CG  1 
ATOM   666  C  CD  . GLU A 1 91  ? 5.321  -66.735 -5.733  1    64.15  ? 90   GLU A CD  1 
ATOM   667  O  OE1 . GLU A 1 91  ? 4.58   -67.036 -4.767  1    67.72  ? 90   GLU A OE1 1 
ATOM   668  O  OE2 . GLU A 1 91  ? 5.094  -67.095 -6.91   1    67.97  ? 90   GLU A OE2 1 
ATOM   669  N  N   . ILE A 1 92  ? 8.282  -64.686 -1.347  1    37.35  ? 91   ILE A N   1 
ATOM   670  C  CA  . ILE A 1 92  ? 8.294  -64.051 -0.029  1    37.76  ? 91   ILE A CA  1 
ATOM   671  C  C   . ILE A 1 92  ? 9.403  -62.989 0.064   1    37.44  ? 91   ILE A C   1 
ATOM   672  O  O   . ILE A 1 92  ? 9.148  -61.854 0.482   1    37.43  ? 91   ILE A O   1 
ATOM   673  C  CB  . ILE A 1 92  ? 8.427  -65.155 1.053   1    38.27  ? 91   ILE A CB  1 
ATOM   674  C  CG1 . ILE A 1 92  ? 7.089  -65.909 1.206   1    39.15  ? 91   ILE A CG1 1 
ATOM   675  C  CG2 . ILE A 1 92  ? 8.915  -64.614 2.392   1    38.93  ? 91   ILE A CG2 1 
ATOM   676  C  CD1 . ILE A 1 92  ? 7.233  -67.235 1.929   1    40.53  ? 91   ILE A CD1 1 
ATOM   677  N  N   . PHE A 1 93  ? 10.616 -63.342 -0.379  1    36.73  ? 92   PHE A N   1 
ATOM   678  C  CA  . PHE A 1 93  ? 11.746 -62.429 -0.32   1    36.48  ? 92   PHE A CA  1 
ATOM   679  C  C   . PHE A 1 93  ? 11.631 -61.296 -1.332  1    35.69  ? 92   PHE A C   1 
ATOM   680  O  O   . PHE A 1 93  ? 11.932 -60.164 -0.969  1    35.8   ? 92   PHE A O   1 
ATOM   681  C  CB  . PHE A 1 93  ? 13.08  -63.185 -0.407  1    37.07  ? 92   PHE A CB  1 
ATOM   682  C  CG  . PHE A 1 93  ? 13.446 -63.706 0.974   1    38.86  ? 92   PHE A CG  1 
ATOM   683  C  CD1 . PHE A 1 93  ? 12.967 -64.925 1.423   1    40.2   ? 92   PHE A CD1 1 
ATOM   684  C  CD2 . PHE A 1 93  ? 14.168 -62.922 1.859   1    40.48  ? 92   PHE A CD2 1 
ATOM   685  C  CE1 . PHE A 1 93  ? 13.244 -65.373 2.716   1    41.34  ? 92   PHE A CE1 1 
ATOM   686  C  CE2 . PHE A 1 93  ? 14.454 -63.376 3.147   1    41.55  ? 92   PHE A CE2 1 
ATOM   687  C  CZ  . PHE A 1 93  ? 13.988 -64.599 3.566   1    41.14  ? 92   PHE A CZ  1 
ATOM   688  N  N   . ASP A 1 94  ? 11.078 -61.555 -2.539  1    34.72  ? 93   ASP A N   1 
ATOM   689  C  CA  . ASP A 1 94  ? 10.852 -60.518 -3.545  1    34.86  ? 93   ASP A CA  1 
ATOM   690  C  C   . ASP A 1 94  ? 9.943  -59.423 -2.965  1    34.72  ? 93   ASP A C   1 
ATOM   691  O  O   . ASP A 1 94  ? 10.261 -58.237 -3.075  1    34.68  ? 93   ASP A O   1 
ATOM   692  C  CB  . ASP A 1 94  ? 10.181 -61.087 -4.819  1    36.17  ? 93   ASP A CB  1 
ATOM   693  C  CG  . ASP A 1 94  ? 11.068 -61.832 -5.817  1    41.42  ? 93   ASP A CG  1 
ATOM   694  O  OD1 . ASP A 1 94  ? 12.32  -61.673 -5.752  1    42.13  ? 93   ASP A OD1 1 
ATOM   695  O  OD2 . ASP A 1 94  ? 10.512 -62.572 -6.661  1    41.98  ? 93   ASP A OD2 1 
ATOM   696  N  N   . LYS A 1 95  ? 8.826  -59.82  -2.316  1    34.17  ? 94   LYS A N   1 
ATOM   697  C  CA  . LYS A 1 95  ? 7.9    -58.838 -1.752  1    34.84  ? 94   LYS A CA  1 
ATOM   698  C  C   . LYS A 1 95  ? 8.471  -58.094 -0.597  1    33.96  ? 94   LYS A C   1 
ATOM   699  O  O   . LYS A 1 95  ? 8.215  -56.895 -0.463  1    34.5   ? 94   LYS A O   1 
ATOM   700  C  CB  . LYS A 1 95  ? 6.566  -59.487 -1.333  1    38.47  ? 94   LYS A CB  1 
ATOM   701  C  CG  . LYS A 1 95  ? 5.758  -60.027 -2.496  1    46.02  ? 94   LYS A CG  1 
ATOM   702  C  CD  . LYS A 1 95  ? 4.264  -59.641 -2.429  1    53.33  ? 94   LYS A CD  1 
ATOM   703  C  CE  . LYS A 1 95  ? 3.624  -59.929 -1.088  1    58.3   ? 94   LYS A CE  1 
ATOM   704  N  NZ  . LYS A 1 95  ? 3.316  -58.674 -0.342  1    61.72  ? 94   LYS A NZ  1 
ATOM   705  N  N   . ALA A 1 96  ? 9.208  -58.794 0.283   1    32.17  ? 95   ALA A N   1 
ATOM   706  C  CA  . ALA A 1 96  ? 9.787  -58.157 1.454   1    31.65  ? 95   ALA A CA  1 
ATOM   707  C  C   . ALA A 1 96  ? 10.842 -57.123 1.049   1    31.92  ? 95   ALA A C   1 
ATOM   708  O  O   . ALA A 1 96  ? 10.89  -56.038 1.631   1    32.62  ? 95   ALA A O   1 
ATOM   709  C  CB  . ALA A 1 96  ? 10.413 -59.211 2.367   1    31.09  ? 95   ALA A CB  1 
ATOM   710  N  N   . ILE A 1 97  ? 11.702 -57.466 0.078   1    31.32  ? 96   ILE A N   1 
ATOM   711  C  CA  . ILE A 1 97  ? 12.753 -56.537 -0.357  1    32.18  ? 96   ILE A CA  1 
ATOM   712  C  C   . ILE A 1 97  ? 12.135 -55.283 -1.011  1    33.38  ? 96   ILE A C   1 
ATOM   713  O  O   . ILE A 1 97  ? 12.548 -54.159 -0.737  1    33.74  ? 96   ILE A O   1 
ATOM   714  C  CB  . ILE A 1 97  ? 13.71  -57.302 -1.302  1    32.98  ? 96   ILE A CB  1 
ATOM   715  C  CG1 . ILE A 1 97  ? 14.47  -58.386 -0.499  1    34.08  ? 96   ILE A CG1 1 
ATOM   716  C  CG2 . ILE A 1 97  ? 14.685 -56.34  -1.992  1    33.08  ? 96   ILE A CG2 1 
ATOM   717  C  CD1 . ILE A 1 97  ? 15.138 -59.433 -1.372  1    35.64  ? 96   ILE A CD1 1 
ATOM   718  N  N   . SER A 1 98  ? 11.088 -55.494 -1.798  1    34.02  ? 97   SER A N   1 
ATOM   719  C  CA  . SER A 1 98  ? 10.362 -54.442 -2.484  1    35.54  ? 97   SER A CA  1 
ATOM   720  C  C   . SER A 1 98  ? 9.622  -53.539 -1.488  1    35.78  ? 97   SER A C   1 
ATOM   721  O  O   . SER A 1 98  ? 9.587  -52.326 -1.681  1    36.64  ? 97   SER A O   1 
ATOM   722  C  CB  . SER A 1 98  ? 9.375  -55.06  -3.473  1    38.87  ? 97   SER A CB  1 
ATOM   723  O  OG  . SER A 1 98  ? 8.806  -54.066 -4.305  1    44     ? 97   SER A OG  1 
ATOM   724  N  N   . ALA A 1 99  ? 9.06   -54.109 -0.404  1    34.84  ? 98   ALA A N   1 
ATOM   725  C  CA  . ALA A 1 99  ? 8.35   -53.298 0.593   1    34.78  ? 98   ALA A CA  1 
ATOM   726  C  C   . ALA A 1 99  ? 9.286  -52.494 1.489   1    34.34  ? 98   ALA A C   1 
ATOM   727  O  O   . ALA A 1 99  ? 8.872  -51.497 2.071   1    35.3   ? 98   ALA A O   1 
ATOM   728  C  CB  . ALA A 1 99  ? 7.454  -54.187 1.454   1    35.22  ? 98   ALA A CB  1 
ATOM   729  N  N   . ARG A 1 100 ? 10.536 -52.937 1.636   1    33.31  ? 99   ARG A N   1 
ATOM   730  C  CA  . ARG A 1 100 ? 11.492 -52.279 2.509   1    32.85  ? 99   ARG A CA  1 
ATOM   731  C  C   . ARG A 1 100 ? 12.003 -50.991 1.884   1    33.22  ? 99   ARG A C   1 
ATOM   732  O  O   . ARG A 1 100 ? 12.556 -51.02  0.783   1    34.09  ? 99   ARG A O   1 
ATOM   733  C  CB  . ARG A 1 100 ? 12.654 -53.229 2.831   1    33.14  ? 99   ARG A CB  1 
ATOM   734  C  CG  . ARG A 1 100 ? 13.61  -52.632 3.832   1    35.13  ? 99   ARG A CG  1 
ATOM   735  C  CD  . ARG A 1 100 ? 14.773 -53.563 4.145   1    37.55  ? 99   ARG A CD  1 
ATOM   736  N  NE  . ARG A 1 100 ? 15.555 -53.894 2.951   1    38.93  ? 99   ARG A NE  1 
ATOM   737  C  CZ  . ARG A 1 100 ? 16.698 -54.573 2.963   1    39.72  ? 99   ARG A CZ  1 
ATOM   738  N  NH1 . ARG A 1 100 ? 17.21  -55.003 4.11    1    36.59  ? 99   ARG A NH1 1 
ATOM   739  N  NH2 . ARG A 1 100 ? 17.335 -54.831 1.827   1    39.5   ? 99   ARG A NH2 1 
ATOM   740  N  N   . LYS A 1 101 ? 11.783 -49.866 2.567   1    32.45  ? 100  LYS A N   1 
ATOM   741  C  CA  . LYS A 1 101 ? 12.159 -48.548 2.092   1    32.64  ? 100  LYS A CA  1 
ATOM   742  C  C   . LYS A 1 101 ? 13.127 -47.912 3.056   1    31.8   ? 100  LYS A C   1 
ATOM   743  O  O   . LYS A 1 101 ? 13.157 -48.283 4.229   1    32.33  ? 100  LYS A O   1 
ATOM   744  C  CB  . LYS A 1 101 ? 10.906 -47.624 2.055   1    35.71  ? 100  LYS A CB  1 
ATOM   745  C  CG  . LYS A 1 101 ? 9.657  -48.199 1.41    1    41.64  ? 100  LYS A CG  1 
ATOM   746  C  CD  . LYS A 1 101 ? 9.862  -48.569 -0.039  1    46.31  ? 100  LYS A CD  1 
ATOM   747  C  CE  . LYS A 1 101 ? 8.557  -49.047 -0.631  1    52.07  ? 100  LYS A CE  1 
ATOM   748  N  NZ  . LYS A 1 101 ? 8.754  -49.673 -1.964  1    56.13  ? 100  LYS A NZ  1 
ATOM   749  N  N   . ILE A 1 102 ? 13.804 -46.829 2.64    1    30.11  ? 101  ILE A N   1 
ATOM   750  C  CA  . ILE A 1 102 ? 14.667 -46.074 3.542   1    28.65  ? 101  ILE A CA  1 
ATOM   751  C  C   . ILE A 1 102 ? 13.843 -45.532 4.735   1    29.29  ? 101  ILE A C   1 
ATOM   752  O  O   . ILE A 1 102 ? 12.689 -45.115 4.559   1    29.06  ? 101  ILE A O   1 
ATOM   753  C  CB  . ILE A 1 102 ? 15.368 -44.92  2.778   1    28.01  ? 101  ILE A CB  1 
ATOM   754  C  CG1 . ILE A 1 102 ? 16.404 -45.505 1.772   1    28.28  ? 101  ILE A CG1 1 
ATOM   755  C  CG2 . ILE A 1 102 ? 15.985 -43.893 3.743   1    27.66  ? 101  ILE A CG2 1 
ATOM   756  C  CD1 . ILE A 1 102 ? 17.223 -44.441 0.964   1    29.66  ? 101  ILE A CD1 1 
ATOM   757  N  N   . ASN A 1 103 ? 14.436 -45.609 5.947   1    28.36  ? 102  ASN A N   1 
ATOM   758  C  CA  . ASN A 1 103 ? 13.866 -45.121 7.197   1    26.93  ? 102  ASN A CA  1 
ATOM   759  C  C   . ASN A 1 103 ? 14.303 -43.679 7.266   1    25.87  ? 102  ASN A C   1 
ATOM   760  O  O   . ASN A 1 103 ? 15.388 -43.379 7.773   1    25.59  ? 102  ASN A O   1 
ATOM   761  C  CB  . ASN A 1 103 ? 14.467 -45.916 8.391   1    26.58  ? 102  ASN A CB  1 
ATOM   762  C  CG  . ASN A 1 103 ? 13.911 -45.506 9.734   1    29.11  ? 102  ASN A CG  1 
ATOM   763  O  OD1 . ASN A 1 103 ? 13.048 -44.622 9.821   1    29.17  ? 102  ASN A OD1 1 
ATOM   764  N  ND2 . ASN A 1 103 ? 14.389 -46.155 10.818  1    27.44  ? 102  ASN A ND2 1 
ATOM   765  N  N   . ARG A 1 104 ? 13.509 -42.764 6.678   1    26.08  ? 103  ARG A N   1 
ATOM   766  C  CA  . ARG A 1 104 ? 13.931 -41.365 6.546   1    26.76  ? 103  ARG A CA  1 
ATOM   767  C  C   . ARG A 1 104 ? 14.372 -40.681 7.835   1    26.7   ? 103  ARG A C   1 
ATOM   768  O  O   . ARG A 1 104 ? 15.428 -40.054 7.772   1    26.53  ? 103  ARG A O   1 
ATOM   769  C  CB  . ARG A 1 104 ? 12.885 -40.524 5.797   1    28.37  ? 103  ARG A CB  1 
ATOM   770  C  CG  . ARG A 1 104 ? 12.586 -41.112 4.419   1    31     ? 103  ARG A CG  1 
ATOM   771  C  CD  . ARG A 1 104 ? 13.683 -40.815 3.382   1    34.4   ? 103  ARG A CD  1 
ATOM   772  N  NE  . ARG A 1 104 ? 13.429 -41.54  2.132   1    36.62  ? 103  ARG A NE  1 
ATOM   773  C  CZ  . ARG A 1 104 ? 14.236 -41.527 1.078   1    35.94  ? 103  ARG A CZ  1 
ATOM   774  N  NH1 . ARG A 1 104 ? 15.347 -40.802 1.093   1    33.57  ? 103  ARG A NH1 1 
ATOM   775  N  NH2 . ARG A 1 104 ? 13.935 -42.234 -0.003  1    35.78  ? 103  ARG A NH2 1 
ATOM   776  N  N   . PRO A 1 105 ? 13.719 -40.811 9.03    1    26.57  ? 104  PRO A N   1 
ATOM   777  C  CA  . PRO A 1 105 ? 14.272 -40.161 10.226  1    26.61  ? 104  PRO A CA  1 
ATOM   778  C  C   . PRO A 1 105 ? 15.654 -40.702 10.632  1    25.3   ? 104  PRO A C   1 
ATOM   779  O  O   . PRO A 1 105 ? 16.46  -39.933 11.128  1    26.1   ? 104  PRO A O   1 
ATOM   780  C  CB  . PRO A 1 105 ? 13.19  -40.429 11.309  1    28.02  ? 104  PRO A CB  1 
ATOM   781  C  CG  . PRO A 1 105 ? 11.933 -40.596 10.522  1    28.41  ? 104  PRO A CG  1 
ATOM   782  C  CD  . PRO A 1 105 ? 12.415 -41.431 9.333   1    26.81  ? 104  PRO A CD  1 
ATOM   783  N  N   . MET A 1 106 ? 15.928 -41.997 10.407  1    24.76  ? 105  MET A N   1 
ATOM   784  C  CA  . MET A 1 106 ? 17.236 -42.559 10.766  1    25.23  ? 105  MET A CA  1 
ATOM   785  C  C   . MET A 1 106 ? 18.287 -41.968 9.802   1    25.1   ? 105  MET A C   1 
ATOM   786  O  O   . MET A 1 106 ? 19.347 -41.523 10.246  1    24.63  ? 105  MET A O   1 
ATOM   787  C  CB  . MET A 1 106 ? 17.22  -44.088 10.68   1    26.39  ? 105  MET A CB  1 
ATOM   788  C  CG  . MET A 1 106 ? 18.527 -44.703 11.178  1    28.58  ? 105  MET A CG  1 
ATOM   789  S  SD  . MET A 1 106 ? 18.668 -44.552 12.985  1    30.82  ? 105  MET A SD  1 
ATOM   790  C  CE  . MET A 1 106 ? 17.308 -45.63  13.499  1    29.18  ? 105  MET A CE  1 
ATOM   791  N  N   . LEU A 1 107 ? 17.957 -41.905 8.498   1    25.86  ? 106  LEU A N   1 
ATOM   792  C  CA  . LEU A 1 107 ? 18.89  -41.299 7.518   1    26.4   ? 106  LEU A CA  1 
ATOM   793  C  C   . LEU A 1 107 ? 19.161 -39.832 7.843   1    26.09  ? 106  LEU A C   1 
ATOM   794  O  O   . LEU A 1 107 ? 20.31  -39.4   7.793   1    25.82  ? 106  LEU A O   1 
ATOM   795  C  CB  . LEU A 1 107 ? 18.347 -41.461 6.106   1    26.24  ? 106  LEU A CB  1 
ATOM   796  C  CG  . LEU A 1 107 ? 19.23  -40.864 4.99    1    28.27  ? 106  LEU A CG  1 
ATOM   797  C  CD1 . LEU A 1 107 ? 20.642 -41.504 4.991   1    29.42  ? 106  LEU A CD1 1 
ATOM   798  C  CD2 . LEU A 1 107 ? 18.56  -41.069 3.617   1    28.3   ? 106  LEU A CD2 1 
ATOM   799  N  N   A GLN A 1 108 ? 18.11  -39.085 8.217   0.5  26.3   ? 107  GLN A N   1 
ATOM   800  N  N   B GLN A 1 108 ? 18.12  -39.04  8.218   0.5  26.24  ? 107  GLN A N   1 
ATOM   801  C  CA  A GLN A 1 108 ? 18.215 -37.679 8.593   0.5  26.83  ? 107  GLN A CA  1 
ATOM   802  C  CA  B GLN A 1 108 ? 18.356 -37.626 8.563   0.5  26.76  ? 107  GLN A CA  1 
ATOM   803  C  C   A GLN A 1 108 ? 19.19  -37.495 9.766   0.5  26.63  ? 107  GLN A C   1 
ATOM   804  C  C   B GLN A 1 108 ? 19.264 -37.488 9.778   0.5  26.59  ? 107  GLN A C   1 
ATOM   805  O  O   A GLN A 1 108 ? 19.991 -36.561 9.766   0.5  26.64  ? 107  GLN A O   1 
ATOM   806  O  O   B GLN A 1 108 ? 20.084 -36.57  9.83    0.5  26.55  ? 107  GLN A O   1 
ATOM   807  C  CB  A GLN A 1 108 ? 16.819 -37.131 8.968   0.5  29.23  ? 107  GLN A CB  1 
ATOM   808  C  CB  B GLN A 1 108 ? 17.054 -36.828 8.775   0.5  29.14  ? 107  GLN A CB  1 
ATOM   809  C  CG  A GLN A 1 108 ? 16.773 -35.618 9.033   0.5  33.75  ? 107  GLN A CG  1 
ATOM   810  C  CG  B GLN A 1 108 ? 16.025 -36.929 7.656   0.5  33.68  ? 107  GLN A CG  1 
ATOM   811  C  CD  A GLN A 1 108 ? 15.386 -35.041 9.221   0.5  38.21  ? 107  GLN A CD  1 
ATOM   812  C  CD  B GLN A 1 108 ? 16.569 -36.927 6.251   0.5  39.89  ? 107  GLN A CD  1 
ATOM   813  O  OE1 A GLN A 1 108 ? 15.176 -34.147 10.04   0.5  39.65  ? 107  GLN A OE1 1 
ATOM   814  O  OE1 B GLN A 1 108 ? 17.16  -35.946 5.772   0.5  41.63  ? 107  GLN A OE1 1 
ATOM   815  N  NE2 A GLN A 1 108 ? 14.415 -35.528 8.463   0.5  39.39  ? 107  GLN A NE2 1 
ATOM   816  N  NE2 B GLN A 1 108 ? 16.374 -38.049 5.569   0.5  40.81  ? 107  GLN A NE2 1 
ATOM   817  N  N   . ALA A 1 109 ? 19.135 -38.406 10.752  1    26.35  ? 108  ALA A N   1 
ATOM   818  C  CA  . ALA A 1 109 ? 19.997 -38.375 11.932  1    26.68  ? 108  ALA A CA  1 
ATOM   819  C  C   . ALA A 1 109 ? 21.464 -38.674 11.502  1    25.81  ? 108  ALA A C   1 
ATOM   820  O  O   . ALA A 1 109 ? 22.362 -37.977 11.934  1    26.69  ? 108  ALA A O   1 
ATOM   821  C  CB  . ALA A 1 109 ? 19.516 -39.42  12.934  1    26.3   ? 108  ALA A CB  1 
ATOM   822  N  N   . ALA A 1 110 ? 21.681 -39.664 10.634  1    25.94  ? 109  ALA A N   1 
ATOM   823  C  CA  . ALA A 1 110 ? 23.048 -39.968 10.15   1    25.71  ? 109  ALA A CA  1 
ATOM   824  C  C   . ALA A 1 110 ? 23.641 -38.761 9.413   1    26.98  ? 109  ALA A C   1 
ATOM   825  O  O   . ALA A 1 110 ? 24.794 -38.392 9.652   1    27.95  ? 109  ALA A O   1 
ATOM   826  C  CB  . ALA A 1 110 ? 23.039 -41.178 9.253   1    26.11  ? 109  ALA A CB  1 
ATOM   827  N  N   . LEU A 1 111 ? 22.829 -38.101 8.554   1    26.82  ? 110  LEU A N   1 
ATOM   828  C  CA  . LEU A 1 111 ? 23.271 -36.905 7.831   1    27.3   ? 110  LEU A CA  1 
ATOM   829  C  C   . LEU A 1 111 ? 23.656 -35.758 8.761   1    28.77  ? 110  LEU A C   1 
ATOM   830  O  O   . LEU A 1 111 ? 24.639 -35.064 8.518   1    29.74  ? 110  LEU A O   1 
ATOM   831  C  CB  . LEU A 1 111 ? 22.163 -36.476 6.848   1    27.53  ? 110  LEU A CB  1 
ATOM   832  C  CG  . LEU A 1 111 ? 22.015 -37.388 5.639   1    30.36  ? 110  LEU A CG  1 
ATOM   833  C  CD1 . LEU A 1 111 ? 20.77  -37.015 4.815   1    31.4   ? 110  LEU A CD1 1 
ATOM   834  C  CD2 . LEU A 1 111 ? 23.255 -37.301 4.762   1    31.58  ? 110  LEU A CD2 1 
ATOM   835  N  N   A MET A 1 112 ? 22.891 -35.572 9.836   0.7  29.22  ? 111  MET A N   1 
ATOM   836  N  N   B MET A 1 112 ? 22.887 -35.556 9.842   0.3  28.47  ? 111  MET A N   1 
ATOM   837  C  CA  A MET A 1 112 ? 23.147 -34.528 10.804  0.7  29.76  ? 111  MET A CA  1 
ATOM   838  C  CA  B MET A 1 112 ? 23.177 -34.495 10.801  0.3  28.49  ? 111  MET A CA  1 
ATOM   839  C  C   A MET A 1 112 ? 24.466 -34.792 11.525  0.7  29.24  ? 111  MET A C   1 
ATOM   840  C  C   B MET A 1 112 ? 24.478 -34.782 11.541  0.3  28.74  ? 111  MET A C   1 
ATOM   841  O  O   A MET A 1 112 ? 25.262 -33.87  11.694  0.7  29.64  ? 111  MET A O   1 
ATOM   842  O  O   B MET A 1 112 ? 25.284 -33.87  11.724  0.3  28.98  ? 111  MET A O   1 
ATOM   843  C  CB  A MET A 1 112 ? 21.995 -34.486 11.826  0.7  31.67  ? 111  MET A CB  1 
ATOM   844  C  CB  B MET A 1 112 ? 22.015 -34.316 11.797  0.3  28.78  ? 111  MET A CB  1 
ATOM   845  C  CG  A MET A 1 112 ? 22.081 -33.329 12.756  0.7  36.91  ? 111  MET A CG  1 
ATOM   846  C  CG  B MET A 1 112 ? 22.292 -33.294 12.887  0.3  30.43  ? 111  MET A CG  1 
ATOM   847  S  SD  A MET A 1 112 ? 21.736 -31.792 11.866  0.7  49.49  ? 111  MET A SD  1 
ATOM   848  S  SD  B MET A 1 112 ? 22.691 -31.642 12.252  0.3  31.03  ? 111  MET A SD  1 
ATOM   849  C  CE  A MET A 1 112 ? 23.309 -31.02  11.96   0.7  46.7   ? 111  MET A CE  1 
ATOM   850  C  CE  B MET A 1 112 ? 21.097 -31.206 11.491  0.3  30.76  ? 111  MET A CE  1 
ATOM   851  N  N   . LEU A 1 113 ? 24.708 -36.047 11.938  1    28.79  ? 112  LEU A N   1 
ATOM   852  C  CA  . LEU A 1 113 ? 25.962 -36.402 12.63   1    29.3   ? 112  LEU A CA  1 
ATOM   853  C  C   . LEU A 1 113 ? 27.147 -36.178 11.703  1    29.68  ? 112  LEU A C   1 
ATOM   854  O  O   . LEU A 1 113 ? 28.14  -35.585 12.119  1    29.66  ? 112  LEU A O   1 
ATOM   855  C  CB  . LEU A 1 113 ? 25.938 -37.857 13.105  1    29.53  ? 112  LEU A CB  1 
ATOM   856  C  CG  . LEU A 1 113 ? 25.045 -38.153 14.302  1    31.2   ? 112  LEU A CG  1 
ATOM   857  C  CD1 . LEU A 1 113 ? 25.151 -39.609 14.68   1    31.86  ? 112  LEU A CD1 1 
ATOM   858  C  CD2 . LEU A 1 113 ? 25.391 -37.278 15.486  1    32.04  ? 112  LEU A CD2 1 
ATOM   859  N  N   . ARG A 1 114 ? 27.002 -36.559 10.427  1    30.12  ? 113  ARG A N   1 
ATOM   860  C  CA  . ARG A 1 114 ? 28.067 -36.322 9.442   1    30.99  ? 113  ARG A CA  1 
ATOM   861  C  C   . ARG A 1 114 ? 28.323 -34.808 9.27    1    33.21  ? 113  ARG A C   1 
ATOM   862  O  O   . ARG A 1 114 ? 29.474 -34.385 9.174   1    34.04  ? 113  ARG A O   1 
ATOM   863  C  CB  . ARG A 1 114 ? 27.697 -36.948 8.101   1    30.5   ? 113  ARG A CB  1 
ATOM   864  C  CG  . ARG A 1 114 ? 28.905 -37.157 7.204   1    32.91  ? 113  ARG A CG  1 
ATOM   865  C  CD  . ARG A 1 114 ? 28.471 -37.842 5.926   1    34.28  ? 113  ARG A CD  1 
ATOM   866  N  NE  . ARG A 1 114 ? 29.605 -38.298 5.116   1    36.55  ? 113  ARG A NE  1 
ATOM   867  C  CZ  . ARG A 1 114 ? 29.594 -38.35  3.783   1    38.85  ? 113  ARG A CZ  1 
ATOM   868  N  NH1 . ARG A 1 114 ? 28.532 -37.93  3.101   1    35.98  ? 113  ARG A NH1 1 
ATOM   869  N  NH2 . ARG A 1 114 ? 30.654 -38.805 3.121   1    39.39  ? 113  ARG A NH2 1 
ATOM   870  N  N   . LYS A 1 115 ? 27.261 -33.997 9.258   1    33.98  ? 114  LYS A N   1 
ATOM   871  C  CA  . LYS A 1 115 ? 27.381 -32.541 9.16    1    36.26  ? 114  LYS A CA  1 
ATOM   872  C  C   . LYS A 1 115 ? 28.136 -31.964 10.366  1    37.64  ? 114  LYS A C   1 
ATOM   873  O  O   . LYS A 1 115 ? 28.826 -30.956 10.239  1    38.27  ? 114  LYS A O   1 
ATOM   874  C  CB  . LYS A 1 115 ? 25.994 -31.887 9.062   1    39.82  ? 114  LYS A CB  1 
ATOM   875  C  CG  . LYS A 1 115 ? 25.961 -30.758 8.047   1    46.87  ? 114  LYS A CG  1 
ATOM   876  C  CD  . LYS A 1 115 ? 25.105 -29.6   8.493   1    52.88  ? 114  LYS A CD  1 
ATOM   877  C  CE  . LYS A 1 115 ? 23.641 -29.936 8.486   1    57.09  ? 114  LYS A CE  1 
ATOM   878  N  NZ  . LYS A 1 115 ? 22.81  -28.782 8.95    1    60.19  ? 114  LYS A NZ  1 
ATOM   879  N  N   . LYS A 1 116 ? 27.989 -32.586 11.535  1    38.5   ? 115  LYS A N   1 
ATOM   880  C  CA  . LYS A 1 116 ? 28.68  -32.155 12.748  1    39.73  ? 115  LYS A CA  1 
ATOM   881  C  C   . LYS A 1 116 ? 30.074 -32.784 12.928  1    41.01  ? 115  LYS A C   1 
ATOM   882  O  O   . LYS A 1 116 ? 30.629 -32.745 14.022  1    42.59  ? 115  LYS A O   1 
ATOM   883  C  CB  . LYS A 1 116 ? 27.795 -32.38  13.984  1    41.71  ? 115  LYS A CB  1 
ATOM   884  C  CG  . LYS A 1 116 ? 26.51  -31.539 13.941  1    45.66  ? 115  LYS A CG  1 
ATOM   885  C  CD  . LYS A 1 116 ? 26.816 -30.046 14.037  1    50.92  ? 115  LYS A CD  1 
ATOM   886  C  CE  . LYS A 1 116 ? 25.578 -29.174 14.02   1    55.16  ? 115  LYS A CE  1 
ATOM   887  N  NZ  . LYS A 1 116 ? 24.526 -29.703 14.925  1    57.37  ? 115  LYS A NZ  1 
ATOM   888  N  N   . GLY A 1 117 ? 30.641 -33.335 11.863  1    40.71  ? 116  GLY A N   1 
ATOM   889  C  CA  . GLY A 1 117 ? 31.997 -33.859 11.896  1    40.38  ? 116  GLY A CA  1 
ATOM   890  C  C   . GLY A 1 117 ? 32.183 -35.338 12.144  1    39.44  ? 116  GLY A C   1 
ATOM   891  O  O   . GLY A 1 117 ? 33.327 -35.796 12.195  1    40.35  ? 116  GLY A O   1 
ATOM   892  N  N   . PHE A 1 118 ? 31.092 -36.102 12.319  1    37.17  ? 117  PHE A N   1 
ATOM   893  C  CA  . PHE A 1 118 ? 31.222 -37.537 12.531  1    35.62  ? 117  PHE A CA  1 
ATOM   894  C  C   . PHE A 1 118 ? 31.601 -38.25  11.248  1    34.21  ? 117  PHE A C   1 
ATOM   895  O  O   . PHE A 1 118 ? 31.164 -37.87  10.171  1    33.75  ? 117  PHE A O   1 
ATOM   896  C  CB  . PHE A 1 118 ? 29.896 -38.154 13.009  1    35.12  ? 117  PHE A CB  1 
ATOM   897  C  CG  . PHE A 1 118 ? 29.662 -38.103 14.498  1    34.86  ? 117  PHE A CG  1 
ATOM   898  C  CD1 . PHE A 1 118 ? 29.643 -36.896 15.171  1    35.38  ? 117  PHE A CD1 1 
ATOM   899  C  CD2 . PHE A 1 118 ? 29.422 -39.259 15.214  1    35.45  ? 117  PHE A CD2 1 
ATOM   900  C  CE1 . PHE A 1 118 ? 29.433 -36.853 16.549  1    36.24  ? 117  PHE A CE1 1 
ATOM   901  C  CE2 . PHE A 1 118 ? 29.203 -39.217 16.588  1    36.34  ? 117  PHE A CE2 1 
ATOM   902  C  CZ  . PHE A 1 118 ? 29.199 -38.012 17.244  1    36.42  ? 117  PHE A CZ  1 
ATOM   903  N  N   . THR A 1 119 ? 32.343 -39.347 11.383  1    33.44  ? 118  THR A N   1 
ATOM   904  C  CA  . THR A 1 119 ? 32.602 -40.248 10.265  1    33.6   ? 118  THR A CA  1 
ATOM   905  C  C   . THR A 1 119 ? 31.441 -41.257 10.351  1    31.44  ? 118  THR A C   1 
ATOM   906  O  O   . THR A 1 119 ? 31.198 -41.8   11.434  1    31.64  ? 118  THR A O   1 
ATOM   907  C  CB  . THR A 1 119 ? 33.944 -40.973 10.455  1    36.02  ? 118  THR A CB  1 
ATOM   908  O  OG1 . THR A 1 119 ? 34.991 -40.01  10.391  1    37.77  ? 118  THR A OG1 1 
ATOM   909  C  CG2 . THR A 1 119 ? 34.168 -42.055 9.42    1    36.44  ? 118  THR A CG2 1 
ATOM   910  N  N   . THR A 1 120 ? 30.678 -41.46  9.268   1    29.48  ? 119  THR A N   1 
ATOM   911  C  CA  . THR A 1 120 ? 29.545 -42.394 9.336   1    28.81  ? 119  THR A CA  1 
ATOM   912  C  C   . THR A 1 120 ? 29.756 -43.586 8.426   1    27.89  ? 119  THR A C   1 
ATOM   913  O  O   . THR A 1 120 ? 30.444 -43.481 7.405   1    28.37  ? 119  THR A O   1 
ATOM   914  C  CB  . THR A 1 120 ? 28.229 -41.673 9.047   1    30.5   ? 119  THR A CB  1 
ATOM   915  O  OG1 . THR A 1 120 ? 28.248 -41.237 7.675   1    30.79  ? 119  THR A OG1 1 
ATOM   916  C  CG2 . THR A 1 120 ? 27.972 -40.485 10.022  1    31.18  ? 119  THR A CG2 1 
ATOM   917  N  N   . ALA A 1 121 ? 29.175 -44.711 8.786   1    26.2   ? 120  ALA A N   1 
ATOM   918  C  CA  . ALA A 1 121 ? 29.277 -45.912 8.001   1    26.55  ? 120  ALA A CA  1 
ATOM   919  C  C   . ALA A 1 121 ? 28.062 -46.782 8.114   1    25.86  ? 120  ALA A C   1 
ATOM   920  O  O   . ALA A 1 121 ? 27.367 -46.771 9.133   1    26.21  ? 120  ALA A O   1 
ATOM   921  C  CB  . ALA A 1 121 ? 30.537 -46.71  8.409   1    27.46  ? 120  ALA A CB  1 
ATOM   922  N  N   . ILE A 1 122 ? 27.824 -47.581 7.084   1    24.61  ? 121  ILE A N   1 
ATOM   923  C  CA  . ILE A 1 122 ? 26.822 -48.61  7.112   1    25.77  ? 121  ILE A CA  1 
ATOM   924  C  C   . ILE A 1 122 ? 27.617 -49.907 7.213   1    27.56  ? 121  ILE A C   1 
ATOM   925  O  O   . ILE A 1 122 ? 28.533 -50.137 6.405   1    27.23  ? 121  ILE A O   1 
ATOM   926  C  CB  . ILE A 1 122 ? 25.972 -48.645 5.83    1    26.8   ? 121  ILE A CB  1 
ATOM   927  C  CG1 . ILE A 1 122 ? 25.237 -47.306 5.601   1    28.27  ? 121  ILE A CG1 1 
ATOM   928  C  CG2 . ILE A 1 122 ? 24.978 -49.84  5.864   1    27.6   ? 121  ILE A CG2 1 
ATOM   929  C  CD1 . ILE A 1 122 ? 24.639 -47.233 4.308   1    29.41  ? 121  ILE A CD1 1 
ATOM   930  N  N   . LEU A 1 123 ? 27.235 -50.78  8.148   1    28.19  ? 122  LEU A N   1 
ATOM   931  C  CA  . LEU A 1 123 ? 27.844 -52.104 8.272   1    29.34  ? 122  LEU A CA  1 
ATOM   932  C  C   . LEU A 1 123 ? 26.68  -53.073 8.23    1    29.82  ? 122  LEU A C   1 
ATOM   933  O  O   . LEU A 1 123 ? 25.75  -52.95  9.03    1    30.99  ? 122  LEU A O   1 
ATOM   934  C  CB  . LEU A 1 123 ? 28.651 -52.24  9.57    1    30.22  ? 122  LEU A CB  1 
ATOM   935  C  CG  . LEU A 1 123 ? 29.117 -53.662 9.884   1    32.96  ? 122  LEU A CG  1 
ATOM   936  C  CD1 . LEU A 1 123 ? 30.095 -54.155 8.829   1    33.28  ? 122  LEU A CD1 1 
ATOM   937  C  CD2 . LEU A 1 123 ? 29.772 -53.734 11.263  1    34.21  ? 122  LEU A CD2 1 
ATOM   938  N  N   . THR A 1 124 ? 26.668 -53.973 7.259   1    29.07  ? 123  THR A N   1 
ATOM   939  C  CA  . THR A 1 124 ? 25.524 -54.862 7.086   1    29.25  ? 123  THR A CA  1 
ATOM   940  C  C   . THR A 1 124 ? 25.89  -56.267 6.664   1    28.61  ? 123  THR A C   1 
ATOM   941  O  O   . THR A 1 124 ? 26.825 -56.461 5.88    1    27.98  ? 123  THR A O   1 
ATOM   942  C  CB  . THR A 1 124 ? 24.544 -54.207 6.055   1    31.74  ? 123  THR A CB  1 
ATOM   943  O  OG1 . THR A 1 124 ? 23.48  -55.101 5.718   1    34.53  ? 123  THR A OG1 1 
ATOM   944  C  CG2 . THR A 1 124 ? 25.241 -53.812 4.739   1    31.65  ? 123  THR A CG2 1 
ATOM   945  N  N   . ASN A 1 125 ? 25.128 -57.261 7.174   1    27.08  ? 124  ASN A N   1 
ATOM   946  C  CA  . ASN A 1 125 ? 25.24  -58.602 6.704   1    27.04  ? 124  ASN A CA  1 
ATOM   947  C  C   . ASN A 1 125 ? 24.295 -58.602 5.49    1    29.17  ? 124  ASN A C   1 
ATOM   948  O  O   . ASN A 1 125 ? 23.087 -58.412 5.657   1    30.47  ? 124  ASN A O   1 
ATOM   949  C  CB  . ASN A 1 125 ? 24.734 -59.618 7.745   1    27.99  ? 124  ASN A CB  1 
ATOM   950  C  CG  . ASN A 1 125 ? 25.785 -60.022 8.758   1    29.72  ? 124  ASN A CG  1 
ATOM   951  O  OD1 . ASN A 1 125 ? 26.958 -59.597 8.689   1    30.07  ? 124  ASN A OD1 1 
ATOM   952  N  ND2 . ASN A 1 125 ? 25.377 -60.831 9.752   1    30.24  ? 124  ASN A ND2 1 
ATOM   953  N  N   . THR A 1 126 ? 24.836 -58.769 4.285   1    28.38  ? 125  THR A N   1 
ATOM   954  C  CA  . THR A 1 126 ? 23.999 -58.775 3.088   1    29.11  ? 125  THR A CA  1 
ATOM   955  C  C   . THR A 1 126 ? 24.497 -59.82  2.07    1    28.87  ? 125  THR A C   1 
ATOM   956  O  O   . THR A 1 126 ? 25.501 -60.484 2.311   1    28.85  ? 125  THR A O   1 
ATOM   957  C  CB  . THR A 1 126 ? 23.849 -57.351 2.536   1    32.07  ? 125  THR A CB  1 
ATOM   958  O  OG1 . THR A 1 126 ? 22.769 -57.387 1.589   1    33.95  ? 125  THR A OG1 1 
ATOM   959  C  CG2 . THR A 1 126 ? 25.14  -56.85  1.901   1    32.37  ? 125  THR A CG2 1 
ATOM   960  N  N   . TRP A 1 127 ? 23.792 -59.98  0.96    1    28.48  ? 126  TRP A N   1 
ATOM   961  C  CA  . TRP A 1 127 ? 24.083 -61.006 -0.021  1    29.46  ? 126  TRP A CA  1 
ATOM   962  C  C   . TRP A 1 127 ? 24.358 -60.441 -1.418  1    28.21  ? 126  TRP A C   1 
ATOM   963  O  O   . TRP A 1 127 ? 24.047 -59.282 -1.702  1    27.63  ? 126  TRP A O   1 
ATOM   964  C  CB  . TRP A 1 127 ? 22.868 -61.955 -0.1    1    31.22  ? 126  TRP A CB  1 
ATOM   965  C  CG  . TRP A 1 127 ? 21.567 -61.246 -0.341  1    35.82  ? 126  TRP A CG  1 
ATOM   966  C  CD1 . TRP A 1 127 ? 21.198 -60.555 -1.458  1    38.26  ? 126  TRP A CD1 1 
ATOM   967  C  CD2 . TRP A 1 127 ? 20.497 -61.095 0.594   1    38.33  ? 126  TRP A CD2 1 
ATOM   968  N  NE1 . TRP A 1 127 ? 19.966 -59.972 -1.269  1    39.89  ? 126  TRP A NE1 1 
ATOM   969  C  CE2 . TRP A 1 127 ? 19.516 -60.281 -0.015  1    39.91  ? 126  TRP A CE2 1 
ATOM   970  C  CE3 . TRP A 1 127 ? 20.27  -61.568 1.89    1    40.27  ? 126  TRP A CE3 1 
ATOM   971  C  CZ2 . TRP A 1 127 ? 18.311 -59.97  0.614   1    41.86  ? 126  TRP A CZ2 1 
ATOM   972  C  CZ3 . TRP A 1 127 ? 19.075 -61.254 2.513   1    42.09  ? 126  TRP A CZ3 1 
ATOM   973  C  CH2 . TRP A 1 127 ? 18.108 -60.476 1.872   1    42.27  ? 126  TRP A CH2 1 
ATOM   974  N  N   . LEU A 1 128 ? 24.856 -61.308 -2.301  1    27.68  ? 127  LEU A N   1 
ATOM   975  C  CA  . LEU A 1 128 ? 25.066 -61.01  -3.709  1    26.66  ? 127  LEU A CA  1 
ATOM   976  C  C   . LEU A 1 128 ? 23.733 -61.289 -4.385  1    26.91  ? 127  LEU A C   1 
ATOM   977  O  O   . LEU A 1 128 ? 23.309 -62.441 -4.494  1    27.61  ? 127  LEU A O   1 
ATOM   978  C  CB  . LEU A 1 128 ? 26.167 -61.907 -4.278  1    25.53  ? 127  LEU A CB  1 
ATOM   979  C  CG  . LEU A 1 128 ? 27.548 -61.65  -3.684  1    25.97  ? 127  LEU A CG  1 
ATOM   980  C  CD1 . LEU A 1 128 ? 28.51  -62.706 -4.13   1    26.33  ? 127  LEU A CD1 1 
ATOM   981  C  CD2 . LEU A 1 128 ? 28.034 -60.211 -3.994  1    27.29  ? 127  LEU A CD2 1 
ATOM   982  N  N   . ASP A 1 129 ? 23.02  -60.223 -4.742  1    25.97  ? 128  ASP A N   1 
ATOM   983  C  CA  . ASP A 1 129 ? 21.676 -60.347 -5.289  1    26.16  ? 128  ASP A CA  1 
ATOM   984  C  C   . ASP A 1 129 ? 21.664 -60.468 -6.8    1    26.65  ? 128  ASP A C   1 
ATOM   985  O  O   . ASP A 1 129 ? 21.929 -59.487 -7.515  1    28.1   ? 128  ASP A O   1 
ATOM   986  C  CB  . ASP A 1 129 ? 20.845 -59.15  -4.819  1    27.68  ? 128  ASP A CB  1 
ATOM   987  C  CG  . ASP A 1 129 ? 19.351 -59.223 -5.054  1    31.59  ? 128  ASP A CG  1 
ATOM   988  O  OD1 . ASP A 1 129 ? 18.894 -60.154 -5.767  1    29.38  ? 128  ASP A OD1 1 
ATOM   989  O  OD2 . ASP A 1 129 ? 18.654 -58.321 -4.591  1    37.55  ? 128  ASP A OD2 1 
ATOM   990  N  N   . ASP A 1 130 ? 21.397 -61.675 -7.286  1    26.21  ? 129  ASP A N   1 
ATOM   991  C  CA  . ASP A 1 130 ? 21.297 -61.942 -8.724  1    25.86  ? 129  ASP A CA  1 
ATOM   992  C  C   . ASP A 1 130 ? 19.872 -62.269 -9.164  1    25.96  ? 129  ASP A C   1 
ATOM   993  O  O   . ASP A 1 130 ? 19.688 -62.886 -10.214 1    26.27  ? 129  ASP A O   1 
ATOM   994  C  CB  . ASP A 1 130 ? 22.228 -63.083 -9.141  1    26.58  ? 129  ASP A CB  1 
ATOM   995  C  CG  . ASP A 1 130 ? 21.996 -64.386 -8.384  1    29.31  ? 129  ASP A CG  1 
ATOM   996  O  OD1 . ASP A 1 130 ? 21.162 -64.39  -7.42   1    29.3   ? 129  ASP A OD1 1 
ATOM   997  O  OD2 . ASP A 1 130 ? 22.656 -65.393 -8.729  1    28.41  ? 129  ASP A OD2 1 
ATOM   998  N  N   . ARG A 1 131 ? 18.882 -61.867 -8.374  1    26.46  ? 130  ARG A N   1 
ATOM   999  C  CA  . ARG A 1 131 ? 17.487 -62.089 -8.759  1    27     ? 130  ARG A CA  1 
ATOM   1000 C  C   . ARG A 1 131 ? 17.133 -61.255 -9.983  1    28.05  ? 130  ARG A C   1 
ATOM   1001 O  O   . ARG A 1 131 ? 17.679 -60.166 -10.162 1    27.72  ? 130  ARG A O   1 
ATOM   1002 C  CB  . ARG A 1 131 ? 16.575 -61.613 -7.622  1    26.46  ? 130  ARG A CB  1 
ATOM   1003 C  CG  . ARG A 1 131 ? 16.588 -62.493 -6.37   1    29.25  ? 130  ARG A CG  1 
ATOM   1004 C  CD  . ARG A 1 131 ? 15.724 -61.847 -5.286  1    29.35  ? 130  ARG A CD  1 
ATOM   1005 N  NE  . ARG A 1 131 ? 16.203 -60.51  -4.954  1    30.93  ? 130  ARG A NE  1 
ATOM   1006 C  CZ  . ARG A 1 131 ? 15.477 -59.4   -5.039  1    32.17  ? 130  ARG A CZ  1 
ATOM   1007 N  NH1 . ARG A 1 131 ? 14.187 -59.464 -5.347  1    32.54  ? 130  ARG A NH1 1 
ATOM   1008 N  NH2 . ARG A 1 131 ? 16.027 -58.222 -4.783  1    30.55  ? 130  ARG A NH2 1 
ATOM   1009 N  N   . ALA A 1 132 ? 16.102 -61.66  -10.722 1    28.82  ? 131  ALA A N   1 
ATOM   1010 C  CA  . ALA A 1 132 ? 15.624 -60.861 -11.857 1    30.36  ? 131  ALA A CA  1 
ATOM   1011 C  C   . ALA A 1 132 ? 15.205 -59.439 -11.414 1    30.76  ? 131  ALA A C   1 
ATOM   1012 O  O   . ALA A 1 132 ? 15.41  -58.477 -12.158 1    32.16  ? 131  ALA A O   1 
ATOM   1013 C  CB  . ALA A 1 132 ? 14.459 -61.571 -12.534 1    31.37  ? 131  ALA A CB  1 
ATOM   1014 N  N   . GLU A 1 133 ? 14.731 -59.29  -10.158 1    29.62  ? 132  GLU A N   1 
ATOM   1015 C  CA  . GLU A 1 133 ? 14.268 -58.021 -9.601  1    29.77  ? 132  GLU A CA  1 
ATOM   1016 C  C   . GLU A 1 133 ? 15.327 -57.253 -8.793  1    28.97  ? 132  GLU A C   1 
ATOM   1017 O  O   . GLU A 1 133 ? 14.99  -56.304 -8.075  1    28.57  ? 132  GLU A O   1 
ATOM   1018 C  CB  . GLU A 1 133 ? 13.008 -58.283 -8.733  1    33.8   ? 132  GLU A CB  1 
ATOM   1019 C  CG  . GLU A 1 133 ? 11.952 -59.16  -9.427  1    40.23  ? 132  GLU A CG  1 
ATOM   1020 C  CD  . GLU A 1 133 ? 12.103 -60.683 -9.418  1    49.46  ? 132  GLU A CD  1 
ATOM   1021 O  OE1 . GLU A 1 133 ? 13.102 -61.206 -8.863  1    46.04  ? 132  GLU A OE1 1 
ATOM   1022 O  OE2 . GLU A 1 133 ? 11.211 -61.357 -9.993  1    54.76  ? 132  GLU A OE2 1 
ATOM   1023 N  N   . ARG A 1 134 ? 16.626 -57.63  -8.934  1    27.41  ? 133  ARG A N   1 
ATOM   1024 C  CA  . ARG A 1 134 ? 17.701 -57.029 -8.159  1    26.18  ? 133  ARG A CA  1 
ATOM   1025 C  C   . ARG A 1 134 ? 17.878 -55.509 -8.31   1    25.63  ? 133  ARG A C   1 
ATOM   1026 O  O   . ARG A 1 134 ? 18.433 -54.896 -7.414  1    26.92  ? 133  ARG A O   1 
ATOM   1027 C  CB  . ARG A 1 134 ? 19.041 -57.741 -8.457  1    26.13  ? 133  ARG A CB  1 
ATOM   1028 C  CG  . ARG A 1 134 ? 19.533 -57.46  -9.891  1    23.94  ? 133  ARG A CG  1 
ATOM   1029 C  CD  . ARG A 1 134 ? 20.499 -58.549 -10.344 1    25.75  ? 133  ARG A CD  1 
ATOM   1030 N  NE  . ARG A 1 134 ? 20.91  -58.423 -11.75  1    24.1   ? 133  ARG A NE  1 
ATOM   1031 C  CZ  . ARG A 1 134 ? 20.195 -58.869 -12.778 1    25.83  ? 133  ARG A CZ  1 
ATOM   1032 N  NH1 . ARG A 1 134 ? 19.016 -59.45  -12.576 1    24.04  ? 133  ARG A NH1 1 
ATOM   1033 N  NH2 . ARG A 1 134 ? 20.658 -58.754 -14.019 1    24.46  ? 133  ARG A NH2 1 
ATOM   1034 N  N   . ASP A 1 135 ? 17.387 -54.904 -9.4    1    25.15  ? 134  ASP A N   1 
ATOM   1035 C  CA  . ASP A 1 135 ? 17.524 -53.461 -9.617  1    26.32  ? 134  ASP A CA  1 
ATOM   1036 C  C   . ASP A 1 135 ? 16.918 -52.616 -8.495  1    27.9   ? 134  ASP A C   1 
ATOM   1037 O  O   . ASP A 1 135 ? 17.488 -51.601 -8.14   1    28.59  ? 134  ASP A O   1 
ATOM   1038 C  CB  . ASP A 1 135 ? 16.93  -53.023 -10.967 1    27.08  ? 134  ASP A CB  1 
ATOM   1039 C  CG  . ASP A 1 135 ? 17.339 -51.608 -11.292 1    32.56  ? 134  ASP A CG  1 
ATOM   1040 O  OD1 . ASP A 1 135 ? 18.53  -51.303 -11.176 1    33.32  ? 134  ASP A OD1 1 
ATOM   1041 O  OD2 . ASP A 1 135 ? 16.449 -50.779 -11.568 1    35.27  ? 134  ASP A OD2 1 
ATOM   1042 N  N   . GLY A 1 136 ? 15.783 -53.034 -7.942  1    28.07  ? 135  GLY A N   1 
ATOM   1043 C  CA  . GLY A 1 136 ? 15.136 -52.277 -6.869  1    29.43  ? 135  GLY A CA  1 
ATOM   1044 C  C   . GLY A 1 136 ? 16.028 -52.072 -5.659  1    29.87  ? 135  GLY A C   1 
ATOM   1045 O  O   . GLY A 1 136 ? 16.144 -50.949 -5.163  1    30.8   ? 135  GLY A O   1 
ATOM   1046 N  N   . LEU A 1 137 ? 16.704 -53.131 -5.212  1    29.84  ? 136  LEU A N   1 
ATOM   1047 C  CA  . LEU A 1 137 ? 17.612 -53     -4.068  1    30.63  ? 136  LEU A CA  1 
ATOM   1048 C  C   . LEU A 1 137 ? 18.906 -52.272 -4.493  1    29.08  ? 136  LEU A C   1 
ATOM   1049 O  O   . LEU A 1 137 ? 19.474 -51.533 -3.698  1    29.38  ? 136  LEU A O   1 
ATOM   1050 C  CB  . LEU A 1 137 ? 17.918 -54.346 -3.426  1    32.31  ? 136  LEU A CB  1 
ATOM   1051 C  CG  . LEU A 1 137 ? 18.806 -54.312 -2.152  1    35.56  ? 136  LEU A CG  1 
ATOM   1052 C  CD1 . LEU A 1 137 ? 18.34  -53.247 -1.127  1    36.9   ? 136  LEU A CD1 1 
ATOM   1053 C  CD2 . LEU A 1 137 ? 18.873 -55.656 -1.523  1    36.75  ? 136  LEU A CD2 1 
ATOM   1054 N  N   . ALA A 1 138 ? 19.33  -52.412 -5.768  1    27.87  ? 137  ALA A N   1 
ATOM   1055 C  CA  . ALA A 1 138 ? 20.511 -51.672 -6.247  1    27.95  ? 137  ALA A CA  1 
ATOM   1056 C  C   . ALA A 1 138 ? 20.222 -50.153 -6.16   1    27.72  ? 137  ALA A C   1 
ATOM   1057 O  O   . ALA A 1 138 ? 21.066 -49.394 -5.69   1    28.35  ? 137  ALA A O   1 
ATOM   1058 C  CB  . ALA A 1 138 ? 20.828 -52.076 -7.681  1    27.75  ? 137  ALA A CB  1 
ATOM   1059 N  N   . GLN A 1 139 ? 19.005 -49.735 -6.52   1    27.63  ? 138  GLN A N   1 
ATOM   1060 C  CA  . GLN A 1 139 ? 18.624 -48.326 -6.438  1    29.42  ? 138  GLN A CA  1 
ATOM   1061 C  C   . GLN A 1 139 ? 18.628 -47.827 -4.987  1    29.08  ? 138  GLN A C   1 
ATOM   1062 O  O   . GLN A 1 139 ? 19.113 -46.727 -4.708  1    28.75  ? 138  GLN A O   1 
ATOM   1063 C  CB  . GLN A 1 139 ? 17.212 -48.108 -7.023  1    32.29  ? 138  GLN A CB  1 
ATOM   1064 C  CG  . GLN A 1 139 ? 17.135 -48.302 -8.515  1    38.63  ? 138  GLN A CG  1 
ATOM   1065 C  CD  . GLN A 1 139 ? 15.772 -47.97  -9.057  1    47.17  ? 138  GLN A CD  1 
ATOM   1066 O  OE1 . GLN A 1 139 ? 15.252 -48.666 -9.934  1    51.04  ? 138  GLN A OE1 1 
ATOM   1067 N  NE2 . GLN A 1 139 ? 15.184 -46.87  -8.589  1    48.32  ? 138  GLN A NE2 1 
ATOM   1068 N  N   . LEU A 1 140 ? 18.06  -48.63  -4.069  1    29.22  ? 139  LEU A N   1 
ATOM   1069 C  CA  . LEU A 1 140 ? 17.996 -48.262 -2.649  1    29.87  ? 139  LEU A CA  1 
ATOM   1070 C  C   . LEU A 1 140 ? 19.411 -48.103 -2.083  1    28.26  ? 139  LEU A C   1 
ATOM   1071 O  O   . LEU A 1 140 ? 19.697 -47.105 -1.426  1    27.89  ? 139  LEU A O   1 
ATOM   1072 C  CB  . LEU A 1 140 ? 17.212 -49.316 -1.856  1    31.25  ? 139  LEU A CB  1 
ATOM   1073 C  CG  . LEU A 1 140 ? 16.845 -48.866 -0.43   1    34.53  ? 139  LEU A CG  1 
ATOM   1074 C  CD1 . LEU A 1 140 ? 15.496 -49.384 -0.027  1    35.62  ? 139  LEU A CD1 1 
ATOM   1075 C  CD2 . LEU A 1 140 ? 17.889 -49.295 0.565   1    35.67  ? 139  LEU A CD2 1 
ATOM   1076 N  N   . MET A 1 141 ? 20.304 -49.048 -2.391  1    28.1   ? 140  MET A N   1 
ATOM   1077 C  CA  . MET A 1 141 ? 21.686 -48.953 -1.925  1    28.23  ? 140  MET A CA  1 
ATOM   1078 C  C   . MET A 1 141 ? 22.398 -47.733 -2.49   1    28.57  ? 140  MET A C   1 
ATOM   1079 O  O   . MET A 1 141 ? 23.163 -47.101 -1.774  1    28.66  ? 140  MET A O   1 
ATOM   1080 C  CB  . MET A 1 141 ? 22.463 -50.252 -2.196  1    29.03  ? 140  MET A CB  1 
ATOM   1081 C  CG  . MET A 1 141 ? 21.967 -51.436 -1.4    1    31.49  ? 140  MET A CG  1 
ATOM   1082 S  SD  . MET A 1 141 ? 21.741 -51.095 0.391   1    38.12  ? 140  MET A SD  1 
ATOM   1083 C  CE  . MET A 1 141 ? 23.413 -50.369 0.828   1    35.37  ? 140  MET A CE  1 
ATOM   1084 N  N   . CYS A 1 142 ? 22.122 -47.371 -3.765  1    28.34  ? 141  CYS A N   1 
ATOM   1085 C  CA  . CYS A 1 142 ? 22.734 -46.174 -4.343  1    29.05  ? 141  CYS A CA  1 
ATOM   1086 C  C   . CYS A 1 142 ? 22.298 -44.938 -3.653  1    28.28  ? 141  CYS A C   1 
ATOM   1087 O  O   . CYS A 1 142 ? 23.125 -44.073 -3.401  1    28.62  ? 141  CYS A O   1 
ATOM   1088 C  CB  . CYS A 1 142 ? 22.435 -46.092 -5.827  1    31.3   ? 141  CYS A CB  1 
ATOM   1089 S  SG  . CYS A 1 142 ? 23.418 -47.233 -6.809  1    35.32  ? 141  CYS A SG  1 
ATOM   1090 N  N   . GLU A 1 143 ? 20.994 -44.834 -3.34   1    28.36  ? 142  GLU A N   1 
ATOM   1091 C  CA  . GLU A 1 143 ? 20.519 -43.649 -2.655  1    28.76  ? 142  GLU A CA  1 
ATOM   1092 C  C   . GLU A 1 143 ? 21.128 -43.543 -1.249  1    29.4   ? 142  GLU A C   1 
ATOM   1093 O  O   . GLU A 1 143 ? 21.645 -42.494 -0.885  1    30.18  ? 142  GLU A O   1 
ATOM   1094 C  CB  . GLU A 1 143 ? 18.989 -43.598 -2.622  1    30.28  ? 142  GLU A CB  1 
ATOM   1095 C  CG  . GLU A 1 143 ? 18.539 -42.289 -1.998  1    33.37  ? 142  GLU A CG  1 
ATOM   1096 C  CD  . GLU A 1 143 ? 17.043 -42.111 -1.847  1    35.56  ? 142  GLU A CD  1 
ATOM   1097 O  OE1 . GLU A 1 143 ? 16.293 -43.062 -2.178  1    38.02  ? 142  GLU A OE1 1 
ATOM   1098 O  OE2 . GLU A 1 143 ? 16.625 -41.019 -1.395  1    32.32  ? 142  GLU A OE2 1 
ATOM   1099 N  N   . LEU A 1 144 ? 21.128 -44.646 -0.501  1    29.39  ? 143  LEU A N   1 
ATOM   1100 C  CA  . LEU A 1 144 ? 21.681 -44.642 0.849   1    29.77  ? 143  LEU A CA  1 
ATOM   1101 C  C   . LEU A 1 144 ? 23.175 -44.358 0.928   1    29.46  ? 143  LEU A C   1 
ATOM   1102 O  O   . LEU A 1 144 ? 23.568 -43.496 1.697   1    29.79  ? 143  LEU A O   1 
ATOM   1103 C  CB  . LEU A 1 144 ? 21.424 -46.008 1.512   1    30.97  ? 143  LEU A CB  1 
ATOM   1104 C  CG  . LEU A 1 144 ? 20.207 -46.127 2.367   1    33.28  ? 143  LEU A CG  1 
ATOM   1105 C  CD1 . LEU A 1 144 ? 20.091 -47.52  2.902   1    33.52  ? 143  LEU A CD1 1 
ATOM   1106 C  CD2 . LEU A 1 144 ? 20.223 -45.099 3.493   1    33.25  ? 143  LEU A CD2 1 
ATOM   1107 N  N   . LYS A 1 145 ? 24.008 -45.078 0.145   1    29.73  ? 144  LYS A N   1 
ATOM   1108 C  CA  . LYS A 1 145 ? 25.464 -45.044 0.276   1    30.88  ? 144  LYS A CA  1 
ATOM   1109 C  C   . LYS A 1 145 ? 26.092 -43.699 0.036   1    31.8   ? 144  LYS A C   1 
ATOM   1110 O  O   . LYS A 1 145 ? 27.1   -43.376 0.678   1    32.43  ? 144  LYS A O   1 
ATOM   1111 C  CB  . LYS A 1 145 ? 26.127 -46.114 -0.598  1    34.24  ? 144  LYS A CB  1 
ATOM   1112 C  CG  . LYS A 1 145 ? 26.101 -45.82  -2.079  1    37.85  ? 144  LYS A CG  1 
ATOM   1113 C  CD  . LYS A 1 145 ? 26.502 -47.044 -2.888  1    43.58  ? 144  LYS A CD  1 
ATOM   1114 C  CE  . LYS A 1 145 ? 27.993 -47.253 -2.971  1    47.97  ? 144  LYS A CE  1 
ATOM   1115 N  NZ  . LYS A 1 145 ? 28.351 -48.245 -4.03   1    50.07  ? 144  LYS A NZ  1 
ATOM   1116 N  N   . MET A 1 146 ? 25.487 -42.881 -0.837  1    31.15  ? 145  MET A N   1 
ATOM   1117 C  CA  . MET A 1 146 ? 26.028 -41.556 -1.104  1    31.52  ? 145  MET A CA  1 
ATOM   1118 C  C   . MET A 1 146 ? 26.077 -40.672 0.129   1    30.54  ? 145  MET A C   1 
ATOM   1119 O  O   . MET A 1 146 ? 26.78  -39.669 0.116   1    31.02  ? 145  MET A O   1 
ATOM   1120 C  CB  . MET A 1 146 ? 25.207 -40.865 -2.204  1    33.5   ? 145  MET A CB  1 
ATOM   1121 C  CG  . MET A 1 146 ? 23.888 -40.315 -1.709  1    36.38  ? 145  MET A CG  1 
ATOM   1122 S  SD  . MET A 1 146 ? 22.995 -39.415 -2.993  1    46.27  ? 145  MET A SD  1 
ATOM   1123 C  CE  . MET A 1 146 ? 22.475 -40.733 -3.946  1    45.34  ? 145  MET A CE  1 
ATOM   1124 N  N   . HIS A 1 147 ? 25.295 -41.011 1.19    1    28.73  ? 146  HIS A N   1 
ATOM   1125 C  CA  . HIS A 1 147 ? 25.248 -40.189 2.398   1    28.19  ? 146  HIS A CA  1 
ATOM   1126 C  C   . HIS A 1 147 ? 26.227 -40.627 3.493   1    27.19  ? 146  HIS A C   1 
ATOM   1127 O  O   . HIS A 1 147 ? 26.3   -39.978 4.538   1    27.46  ? 146  HIS A O   1 
ATOM   1128 C  CB  . HIS A 1 147 ? 23.811 -40.193 2.929   1    27.84  ? 146  HIS A CB  1 
ATOM   1129 C  CG  . HIS A 1 147 ? 22.821 -39.712 1.911   1    27.48  ? 146  HIS A CG  1 
ATOM   1130 N  ND1 . HIS A 1 147 ? 22.887 -38.429 1.402   1    28.16  ? 146  HIS A ND1 1 
ATOM   1131 C  CD2 . HIS A 1 147 ? 21.759 -40.346 1.37    1    28.07  ? 146  HIS A CD2 1 
ATOM   1132 C  CE1 . HIS A 1 147 ? 21.865 -38.315 0.564   1    28.75  ? 146  HIS A CE1 1 
ATOM   1133 N  NE2 . HIS A 1 147 ? 21.158 -39.444 0.502   1    28.93  ? 146  HIS A NE2 1 
ATOM   1134 N  N   . PHE A 1 148 ? 27     -41.68  3.24    1    26.56  ? 147  PHE A N   1 
ATOM   1135 C  CA  . PHE A 1 148 ? 27.901 -42.221 4.263   1    27.21  ? 147  PHE A CA  1 
ATOM   1136 C  C   . PHE A 1 148 ? 29.358 -42.227 3.814   1    28.26  ? 147  PHE A C   1 
ATOM   1137 O  O   . PHE A 1 148 ? 29.633 -42.33  2.616   1    28.48  ? 147  PHE A O   1 
ATOM   1138 C  CB  . PHE A 1 148 ? 27.463 -43.664 4.606   1    26.75  ? 147  PHE A CB  1 
ATOM   1139 C  CG  . PHE A 1 148 ? 26.139 -43.67  5.33    1    26.42  ? 147  PHE A CG  1 
ATOM   1140 C  CD1 . PHE A 1 148 ? 24.949 -43.556 4.631   1    27.21  ? 147  PHE A CD1 1 
ATOM   1141 C  CD2 . PHE A 1 148 ? 26.085 -43.792 6.716   1    27.59  ? 147  PHE A CD2 1 
ATOM   1142 C  CE1 . PHE A 1 148 ? 23.732 -43.552 5.291   1    27.94  ? 147  PHE A CE1 1 
ATOM   1143 C  CE2 . PHE A 1 148 ? 24.871 -43.748 7.38    1    27.94  ? 147  PHE A CE2 1 
ATOM   1144 C  CZ  . PHE A 1 148 ? 23.703 -43.637 6.665   1    27.94  ? 147  PHE A CZ  1 
ATOM   1145 N  N   . ASP A 1 149 ? 30.279 -42.155 4.778   1    28.13  ? 148  ASP A N   1 
ATOM   1146 C  CA  . ASP A 1 149 ? 31.711 -42.217 4.432   1    28.87  ? 148  ASP A CA  1 
ATOM   1147 C  C   . ASP A 1 149 ? 32.099 -43.608 3.979   1    28.73  ? 148  ASP A C   1 
ATOM   1148 O  O   . ASP A 1 149 ? 32.967 -43.741 3.118   1    28.61  ? 148  ASP A O   1 
ATOM   1149 C  CB  . ASP A 1 149 ? 32.581 -41.754 5.595   1    30.74  ? 148  ASP A CB  1 
ATOM   1150 C  CG  . ASP A 1 149 ? 32.34  -40.294 5.917   1    35.72  ? 148  ASP A CG  1 
ATOM   1151 O  OD1 . ASP A 1 149 ? 32.77  -39.436 5.127   1    37.32  ? 148  ASP A OD1 1 
ATOM   1152 O  OD2 . ASP A 1 149 ? 31.692 -40.014 6.933   1    36.9   ? 148  ASP A OD2 1 
ATOM   1153 N  N   . PHE A 1 150 ? 31.486 -44.659 4.576   1    27.93  ? 149  PHE A N   1 
ATOM   1154 C  CA  . PHE A 1 150 ? 31.817 -46.043 4.231   1    28.41  ? 149  PHE A CA  1 
ATOM   1155 C  C   . PHE A 1 150 ? 30.598 -46.932 4.198   1    28.29  ? 149  PHE A C   1 
ATOM   1156 O  O   . PHE A 1 150 ? 29.644 -46.725 4.949   1    28.02  ? 149  PHE A O   1 
ATOM   1157 C  CB  . PHE A 1 150 ? 32.808 -46.651 5.267   1    28.81  ? 149  PHE A CB  1 
ATOM   1158 C  CG  . PHE A 1 150 ? 34.093 -45.879 5.415   1    30.19  ? 149  PHE A CG  1 
ATOM   1159 C  CD1 . PHE A 1 150 ? 35.13  -46.045 4.504   1    31.54  ? 149  PHE A CD1 1 
ATOM   1160 C  CD2 . PHE A 1 150 ? 34.236 -44.93  6.412   1    31.41  ? 149  PHE A CD2 1 
ATOM   1161 C  CE1 . PHE A 1 150 ? 36.294 -45.29  4.606   1    31.93  ? 149  PHE A CE1 1 
ATOM   1162 C  CE2 . PHE A 1 150 ? 35.402 -44.191 6.528   1    32.41  ? 149  PHE A CE2 1 
ATOM   1163 C  CZ  . PHE A 1 150 ? 36.424 -44.371 5.616   1    32.12  ? 149  PHE A CZ  1 
ATOM   1164 N  N   . LEU A 1 151 ? 30.639 -47.943 3.335   1    28.26  ? 150  LEU A N   1 
ATOM   1165 C  CA  . LEU A 1 151 ? 29.628 -48.986 3.251   1    28.2   ? 150  LEU A CA  1 
ATOM   1166 C  C   . LEU A 1 151 ? 30.408 -50.31  3.339   1    28.77  ? 150  LEU A C   1 
ATOM   1167 O  O   . LEU A 1 151 ? 31.267 -50.575 2.499   1    29.48  ? 150  LEU A O   1 
ATOM   1168 C  CB  . LEU A 1 151 ? 28.85  -48.911 1.939   1    28.3   ? 150  LEU A CB  1 
ATOM   1169 C  CG  . LEU A 1 151 ? 27.972 -50.119 1.598   1    29.16  ? 150  LEU A CG  1 
ATOM   1170 C  CD1 . LEU A 1 151 ? 26.887 -50.334 2.67    1    28.46  ? 150  LEU A CD1 1 
ATOM   1171 C  CD2 . LEU A 1 151 ? 27.317 -49.956 0.223   1    30.81  ? 150  LEU A CD2 1 
ATOM   1172 N  N   . ILE A 1 152 ? 30.139 -51.119 4.37    1    27.69  ? 151  ILE A N   1 
ATOM   1173 C  CA  . ILE A 1 152 ? 30.824 -52.387 4.562   1    28.05  ? 151  ILE A CA  1 
ATOM   1174 C  C   . ILE A 1 152 ? 29.796 -53.465 4.49    1    27.52  ? 151  ILE A C   1 
ATOM   1175 O  O   . ILE A 1 152 ? 28.845 -53.461 5.271   1    27.27  ? 151  ILE A O   1 
ATOM   1176 C  CB  . ILE A 1 152 ? 31.601 -52.42  5.888   1    29.84  ? 151  ILE A CB  1 
ATOM   1177 C  CG1 . ILE A 1 152 ? 32.676 -51.325 5.916   1    31.86  ? 151  ILE A CG1 1 
ATOM   1178 C  CG2 . ILE A 1 152 ? 32.238 -53.817 6.081   1    31.04  ? 151  ILE A CG2 1 
ATOM   1179 C  CD1 . ILE A 1 152 ? 33.224 -51.095 7.296   1    34.21  ? 151  ILE A CD1 1 
ATOM   1180 N  N   . GLU A 1 153 ? 29.913 -54.332 3.494   1    26.69  ? 152  GLU A N   1 
ATOM   1181 C  CA  . GLU A 1 153 ? 28.964 -55.397 3.251   1    27.04  ? 152  GLU A CA  1 
ATOM   1182 C  C   . GLU A 1 153 ? 29.624 -56.729 3.465   1    27.77  ? 152  GLU A C   1 
ATOM   1183 O  O   . GLU A 1 153 ? 30.65  -57.025 2.843   1    27.72  ? 152  GLU A O   1 
ATOM   1184 C  CB  . GLU A 1 153 ? 28.403 -55.297 1.83    1    29.84  ? 152  GLU A CB  1 
ATOM   1185 C  CG  . GLU A 1 153 ? 27.597 -54.028 1.608   1    34.29  ? 152  GLU A CG  1 
ATOM   1186 C  CD  . GLU A 1 153 ? 27.169 -53.825 0.166   1    45.26  ? 152  GLU A CD  1 
ATOM   1187 O  OE1 . GLU A 1 153 ? 25.962 -53.604 -0.078  1    46.96  ? 152  GLU A OE1 1 
ATOM   1188 O  OE2 . GLU A 1 153 ? 28.043 -53.898 -0.727  1    48.56  ? 152  GLU A OE2 1 
ATOM   1189 N  N   . SER A 1 154 ? 29.004 -57.568 4.304   1    26.87  ? 153  SER A N   1 
ATOM   1190 C  CA  . SER A 1 154 ? 29.526 -58.889 4.652   1    26.12  ? 153  SER A CA  1 
ATOM   1191 C  C   . SER A 1 154 ? 29.945 -59.725 3.423   1    26.61  ? 153  SER A C   1 
ATOM   1192 O  O   . SER A 1 154 ? 31.031 -60.308 3.419   1    28.11  ? 153  SER A O   1 
ATOM   1193 C  CB  . SER A 1 154 ? 28.484 -59.646 5.485   1    25.3   ? 153  SER A CB  1 
ATOM   1194 O  OG  . SER A 1 154 ? 27.407 -60.091 4.673   1    26.97  ? 153  SER A OG  1 
ATOM   1195 N  N   . CYS A 1 155 ? 29.107 -59.762 2.371   1    25.55  ? 154  CYS A N   1 
ATOM   1196 C  CA  . CYS A 1 155 ? 29.41  -60.567 1.184   1    26.41  ? 154  CYS A CA  1 
ATOM   1197 C  C   . CYS A 1 155 ? 30.586 -60.043 0.355   1    27.17  ? 154  CYS A C   1 
ATOM   1198 O  O   . CYS A 1 155 ? 31.094 -60.775 -0.497  1    27.43  ? 154  CYS A O   1 
ATOM   1199 C  CB  . CYS A 1 155 ? 28.176 -60.747 0.326   1    27.89  ? 154  CYS A CB  1 
ATOM   1200 S  SG  . CYS A 1 155 ? 27.416 -59.176 -0.148  1    30.85  ? 154  CYS A SG  1 
ATOM   1201 N  N   A GLN A 1 156 ? 31.01  -58.806 0.581   0.5  28.15  ? 155  GLN A N   1 
ATOM   1202 N  N   B GLN A 1 156 ? 31.004 -58.796 0.578   0.5  27.85  ? 155  GLN A N   1 
ATOM   1203 C  CA  A GLN A 1 156 ? 32.176 -58.262 -0.115  0.5  30.17  ? 155  GLN A CA  1 
ATOM   1204 C  CA  B GLN A 1 156 ? 32.142 -58.223 -0.144  0.5  29.57  ? 155  GLN A CA  1 
ATOM   1205 C  C   A GLN A 1 156 ? 33.439 -58.6   0.676   0.5  31.37  ? 155  GLN A C   1 
ATOM   1206 C  C   B GLN A 1 156 ? 33.456 -58.282 0.677   0.5  31.02  ? 155  GLN A C   1 
ATOM   1207 O  O   A GLN A 1 156 ? 34.466 -58.975 0.098   0.5  31.65  ? 155  GLN A O   1 
ATOM   1208 O  O   B GLN A 1 156 ? 34.543 -58.212 0.103   0.5  31.28  ? 155  GLN A O   1 
ATOM   1209 C  CB  A GLN A 1 156 ? 32.068 -56.733 -0.217  0.5  32.78  ? 155  GLN A CB  1 
ATOM   1210 C  CB  B GLN A 1 156 ? 31.809 -56.809 -0.643  0.5  31.38  ? 155  GLN A CB  1 
ATOM   1211 C  CG  A GLN A 1 156 ? 30.778 -56.245 -0.843  0.5  38.55  ? 155  GLN A CG  1 
ATOM   1212 C  CG  B GLN A 1 156 ? 30.61  -56.802 -1.611  0.5  35.11  ? 155  GLN A CG  1 
ATOM   1213 C  CD  A GLN A 1 156 ? 30.752 -56.509 -2.313  0.5  44.05  ? 155  GLN A CD  1 
ATOM   1214 C  CD  B GLN A 1 156 ? 30.216 -55.416 -2.067  0.5  41.06  ? 155  GLN A CD  1 
ATOM   1215 O  OE1 A GLN A 1 156 ? 29.844 -57.16  -2.84   0.5  45.67  ? 155  GLN A OE1 1 
ATOM   1216 O  OE1 B GLN A 1 156 ? 30.571 -54.416 -1.454  0.5  41.82  ? 155  GLN A OE1 1 
ATOM   1217 N  NE2 A GLN A 1 156 ? 31.77  -56.029 -3.014  0.5  45.19  ? 155  GLN A NE2 1 
ATOM   1218 N  NE2 B GLN A 1 156 ? 29.443 -55.311 -3.135  0.5  43.05  ? 155  GLN A NE2 1 
ATOM   1219 N  N   . VAL A 1 157 ? 33.37  -58.467 2.009   1    31.37  ? 156  VAL A N   1 
ATOM   1220 C  CA  . VAL A 1 157 ? 34.556 -58.642 2.843   1    32.51  ? 156  VAL A CA  1 
ATOM   1221 C  C   . VAL A 1 157 ? 34.779 -60.099 3.3     1    33.01  ? 156  VAL A C   1 
ATOM   1222 O  O   . VAL A 1 157 ? 35.82  -60.387 3.875   1    33.99  ? 156  VAL A O   1 
ATOM   1223 C  CB  . VAL A 1 157 ? 34.572 -57.648 4.022   1    33.43  ? 156  VAL A CB  1 
ATOM   1224 C  CG1 . VAL A 1 157 ? 34.535 -56.195 3.505   1    34.53  ? 156  VAL A CG1 1 
ATOM   1225 C  CG2 . VAL A 1 157 ? 33.407 -57.908 4.977   1    33.14  ? 156  VAL A CG2 1 
ATOM   1226 N  N   . GLY A 1 158 ? 33.823 -60.989 3.06    1    32.3   ? 157  GLY A N   1 
ATOM   1227 C  CA  . GLY A 1 158 ? 33.921 -62.395 3.433   1    32.61  ? 157  GLY A CA  1 
ATOM   1228 C  C   . GLY A 1 158 ? 33.858 -62.683 4.92    1    33.08  ? 157  GLY A C   1 
ATOM   1229 O  O   . GLY A 1 158 ? 34.319 -63.736 5.378   1    32.91  ? 157  GLY A O   1 
ATOM   1230 N  N   . MET A 1 159 ? 33.309 -61.737 5.687   1    32.34  ? 158  MET A N   1 
ATOM   1231 C  CA  . MET A 1 159 ? 33.182 -61.813 7.145   1    32.9   ? 158  MET A CA  1 
ATOM   1232 C  C   . MET A 1 159 ? 31.761 -61.433 7.498   1    33.17  ? 158  MET A C   1 
ATOM   1233 O  O   . MET A 1 159 ? 31.181 -60.584 6.815   1    33.11  ? 158  MET A O   1 
ATOM   1234 C  CB  . MET A 1 159 ? 34.082 -60.765 7.79    1    33.89  ? 158  MET A CB  1 
ATOM   1235 C  CG  . MET A 1 159 ? 35.537 -60.936 7.482   1    36.5   ? 158  MET A CG  1 
ATOM   1236 S  SD  . MET A 1 159 ? 36.411 -59.595 8.287   1    44.98  ? 158  MET A SD  1 
ATOM   1237 C  CE  . MET A 1 159 ? 36.66  -58.545 6.988   1    45.68  ? 158  MET A CE  1 
ATOM   1238 N  N   . VAL A 1 160 ? 31.204 -62.006 8.58    1    32.25  ? 159  VAL A N   1 
ATOM   1239 C  CA  . VAL A 1 160 ? 29.833 -61.668 8.963   1    31.73  ? 159  VAL A CA  1 
ATOM   1240 C  C   . VAL A 1 160 ? 29.748 -61.282 10.42   1    31.9   ? 159  VAL A C   1 
ATOM   1241 O  O   . VAL A 1 160 ? 30.559 -61.716 11.254  1    31.79  ? 159  VAL A O   1 
ATOM   1242 C  CB  . VAL A 1 160 ? 28.821 -62.814 8.661   1    32.23  ? 159  VAL A CB  1 
ATOM   1243 C  CG1 . VAL A 1 160 ? 28.689 -63.077 7.176   1    31.96  ? 159  VAL A CG1 1 
ATOM   1244 C  CG2 . VAL A 1 160 ? 29.172 -64.115 9.418   1    32.35  ? 159  VAL A CG2 1 
ATOM   1245 N  N   . LYS A 1 161 ? 28.754 -60.472 10.758  1    30.95  ? 160  LYS A N   1 
ATOM   1246 C  CA  . LYS A 1 161 ? 28.405 -60.235 12.153  1    31.65  ? 160  LYS A CA  1 
ATOM   1247 C  C   . LYS A 1 161 ? 27.682 -61.554 12.584  1    32.45  ? 160  LYS A C   1 
ATOM   1248 O  O   . LYS A 1 161 ? 26.964 -62.159 11.772  1    31.05  ? 160  LYS A O   1 
ATOM   1249 C  CB  . LYS A 1 161 ? 27.423 -59.058 12.239  1    30.73  ? 160  LYS A CB  1 
ATOM   1250 C  CG  . LYS A 1 161 ? 28.072 -57.705 11.944  1    32.47  ? 160  LYS A CG  1 
ATOM   1251 C  CD  . LYS A 1 161 ? 27.098 -56.512 12.197  1    34.2   ? 160  LYS A CD  1 
ATOM   1252 C  CE  . LYS A 1 161 ? 25.792 -56.699 11.462  1    36.81  ? 160  LYS A CE  1 
ATOM   1253 N  NZ  . LYS A 1 161 ? 24.808 -55.613 11.761  1    39.76  ? 160  LYS A NZ  1 
ATOM   1254 N  N   . PRO A 1 162 ? 27.934 -62.089 13.799  1    34.47  ? 161  PRO A N   1 
ATOM   1255 C  CA  . PRO A 1 162 ? 28.698 -61.502 14.906  1    35.97  ? 161  PRO A CA  1 
ATOM   1256 C  C   . PRO A 1 162 ? 30.162 -61.959 15.101  1    37.89  ? 161  PRO A C   1 
ATOM   1257 O  O   . PRO A 1 162 ? 30.645 -61.895 16.232  1    38.27  ? 161  PRO A O   1 
ATOM   1258 C  CB  . PRO A 1 162 ? 27.863 -61.924 16.124  1    36.6   ? 161  PRO A CB  1 
ATOM   1259 C  CG  . PRO A 1 162 ? 27.334 -63.304 15.747  1    36.62  ? 161  PRO A CG  1 
ATOM   1260 C  CD  . PRO A 1 162 ? 27.23  -63.324 14.221  1    34.45  ? 161  PRO A CD  1 
ATOM   1261 N  N   A GLU A 1 163 ? 30.857 -62.396 14.031  0.5  37.82  ? 162  GLU A N   1 
ATOM   1262 N  N   B GLU A 1 163 ? 30.844 -62.43  14.049  0.5  38.48  ? 162  GLU A N   1 
ATOM   1263 C  CA  A GLU A 1 163 ? 32.262 -62.827 14.121  0.5  38.06  ? 162  GLU A CA  1 
ATOM   1264 C  CA  B GLU A 1 163 ? 32.238 -62.873 14.191  0.5  39.38  ? 162  GLU A CA  1 
ATOM   1265 C  C   A GLU A 1 163 ? 33.126 -61.657 14.537  0.5  39.11  ? 162  GLU A C   1 
ATOM   1266 C  C   B GLU A 1 163 ? 33.132 -61.682 14.529  0.5  39.72  ? 162  GLU A C   1 
ATOM   1267 O  O   A GLU A 1 163 ? 32.944 -60.564 14.007  0.5  38.9   ? 162  GLU A O   1 
ATOM   1268 O  O   B GLU A 1 163 ? 32.922 -60.591 14.008  0.5  39.57  ? 162  GLU A O   1 
ATOM   1269 C  CB  A GLU A 1 163 ? 32.779 -63.326 12.76   0.5  38.65  ? 162  GLU A CB  1 
ATOM   1270 C  CB  B GLU A 1 163 ? 32.723 -63.592 12.923  0.5  42.33  ? 162  GLU A CB  1 
ATOM   1271 C  CG  A GLU A 1 163 ? 31.941 -64.41  12.12   0.5  39.28  ? 162  GLU A CG  1 
ATOM   1272 C  CG  B GLU A 1 163 ? 31.767 -64.66  12.425  0.5  48.51  ? 162  GLU A CG  1 
ATOM   1273 C  CD  A GLU A 1 163 ? 32.491 -64.944 10.81   0.5  38.62  ? 162  GLU A CD  1 
ATOM   1274 C  CD  B GLU A 1 163 ? 31.562 -65.838 13.354  0.5  57.04  ? 162  GLU A CD  1 
ATOM   1275 O  OE1 A GLU A 1 163 ? 32.415 -66.182 10.62   0.5  36.54  ? 162  GLU A OE1 1 
ATOM   1276 O  OE1 B GLU A 1 163 ? 32.561 -66.332 13.926  0.5  58.8   ? 162  GLU A OE1 1 
ATOM   1277 O  OE2 A GLU A 1 163 ? 32.996 -64.143 9.983   0.5  36.2   ? 162  GLU A OE2 1 
ATOM   1278 O  OE2 B GLU A 1 163 ? 30.397 -66.278 13.499  0.5  60.4   ? 162  GLU A OE2 1 
ATOM   1279 N  N   . PRO A 1 164 ? 34.12  -61.852 15.422  1    39.62  ? 163  PRO A N   1 
ATOM   1280 C  CA  . PRO A 1 164 ? 34.95  -60.702 15.843  1    39.43  ? 163  PRO A CA  1 
ATOM   1281 C  C   . PRO A 1 164 ? 35.729 -59.945 14.766  1    39.16  ? 163  PRO A C   1 
ATOM   1282 O  O   . PRO A 1 164 ? 36.012 -58.749 14.945  1    39.53  ? 163  PRO A O   1 
ATOM   1283 C  CB  . PRO A 1 164 ? 35.925 -61.331 16.856  1    40.89  ? 163  PRO A CB  1 
ATOM   1284 C  CG  . PRO A 1 164 ? 35.201 -62.53  17.378  1    41.75  ? 163  PRO A CG  1 
ATOM   1285 C  CD  . PRO A 1 164 ? 34.471 -63.077 16.177  1    39.91  ? 163  PRO A CD  1 
ATOM   1286 N  N   . GLN A 1 165 ? 36.111 -60.63  13.679  1    38.25  ? 164  GLN A N   1 
ATOM   1287 C  CA  . GLN A 1 165 ? 36.935 -60.022 12.646  1    37.82  ? 164  GLN A CA  1 
ATOM   1288 C  C   . GLN A 1 165 ? 36.284 -58.848 11.941  1    35.49  ? 164  GLN A C   1 
ATOM   1289 O  O   . GLN A 1 165 ? 36.981 -57.899 11.629  1    35.18  ? 164  GLN A O   1 
ATOM   1290 C  CB  . GLN A 1 165 ? 37.415 -61.06  11.625  1    41.66  ? 164  GLN A CB  1 
ATOM   1291 C  CG  . GLN A 1 165 ? 36.292 -61.907 11.038  1    49.05  ? 164  GLN A CG  1 
ATOM   1292 C  CD  . GLN A 1 165 ? 36.811 -63.219 10.515  1    57.48  ? 164  GLN A CD  1 
ATOM   1293 O  OE1 . GLN A 1 165 ? 37.673 -63.274 9.629   1    59.85  ? 164  GLN A OE1 1 
ATOM   1294 N  NE2 . GLN A 1 165 ? 36.294 -64.305 11.064  1    59.64  ? 164  GLN A NE2 1 
ATOM   1295 N  N   . ILE A 1 166 ? 34.98  -58.911 11.687  1    34.45  ? 165  ILE A N   1 
ATOM   1296 C  CA  . ILE A 1 166 ? 34.298 -57.809 10.989  1    33.63  ? 165  ILE A CA  1 
ATOM   1297 C  C   . ILE A 1 166 ? 34.318 -56.538 11.847  1    33.26  ? 165  ILE A C   1 
ATOM   1298 O  O   . ILE A 1 166 ? 34.471 -55.448 11.292  1    33.3   ? 165  ILE A O   1 
ATOM   1299 C  CB  . ILE A 1 166 ? 32.892 -58.198 10.461  1    33.42  ? 165  ILE A CB  1 
ATOM   1300 C  CG1 . ILE A 1 166 ? 32.428 -57.22  9.341   1    33.71  ? 165  ILE A CG1 1 
ATOM   1301 C  CG2 . ILE A 1 166 ? 31.855 -58.305 11.587  1    33.97  ? 165  ILE A CG2 1 
ATOM   1302 C  CD1 . ILE A 1 166 ? 31.306 -57.676 8.591   1    34.07  ? 165  ILE A CD1 1 
ATOM   1303 N  N   . TYR A 1 167 ? 34.307 -56.661 13.195  1    32.79  ? 166  TYR A N   1 
ATOM   1304 C  CA  . TYR A 1 167 ? 34.382 -55.487 14.06   1    32.88  ? 166  TYR A CA  1 
ATOM   1305 C  C   . TYR A 1 167 ? 35.752 -54.862 14.043  1    33.76  ? 166  TYR A C   1 
ATOM   1306 O  O   . TYR A 1 167 ? 35.864 -53.642 14.005  1    33.61  ? 166  TYR A O   1 
ATOM   1307 C  CB  . TYR A 1 167 ? 33.892 -55.793 15.488  1    32.57  ? 166  TYR A CB  1 
ATOM   1308 C  CG  . TYR A 1 167 ? 32.506 -56.377 15.489  1    32.33  ? 166  TYR A CG  1 
ATOM   1309 C  CD1 . TYR A 1 167 ? 32.303 -57.73  15.29   1    33.04  ? 166  TYR A CD1 1 
ATOM   1310 C  CD2 . TYR A 1 167 ? 31.391 -55.576 15.688  1    32.98  ? 166  TYR A CD2 1 
ATOM   1311 C  CE1 . TYR A 1 167 ? 31.023 -58.267 15.219  1    33.89  ? 166  TYR A CE1 1 
ATOM   1312 C  CE2 . TYR A 1 167 ? 30.109 -56.112 15.681  1    33.38  ? 166  TYR A CE2 1 
ATOM   1313 C  CZ  . TYR A 1 167 ? 29.926 -57.45  15.418  1    34.05  ? 166  TYR A CZ  1 
ATOM   1314 O  OH  . TYR A 1 167 ? 28.677 -57.996 15.422  1    34.64  ? 166  TYR A OH  1 
ATOM   1315 N  N   . LYS A 1 168 ? 36.83  -55.697 14.036  1    34.22  ? 167  LYS A N   1 
ATOM   1316 C  CA  . LYS A 1 168 ? 38.173 -55.148 13.942  1    34.29  ? 167  LYS A CA  1 
ATOM   1317 C  C   . LYS A 1 168 ? 38.372 -54.519 12.544  1    34.13  ? 167  LYS A C   1 
ATOM   1318 O  O   . LYS A 1 168 ? 39.015 -53.479 12.438  1    34.97  ? 167  LYS A O   1 
ATOM   1319 C  CB  . LYS A 1 168 ? 39.22  -56.236 14.255  1    36.9   ? 167  LYS A CB  1 
ATOM   1320 C  CG  . LYS A 1 168 ? 39.201 -56.654 15.74   1    40.3   ? 167  LYS A CG  1 
ATOM   1321 C  CD  . LYS A 1 168 ? 39.909 -55.635 16.666  1    44.98  ? 167  LYS A CD  1 
ATOM   1322 C  CE  . LYS A 1 168 ? 40.196 -56.225 18.045  1    48.61  ? 167  LYS A CE  1 
ATOM   1323 N  NZ  . LYS A 1 168 ? 41.211 -55.437 18.829  1    50.9   ? 167  LYS A NZ  1 
ATOM   1324 N  N   . PHE A 1 169 ? 37.789 -55.114 11.492  1    34.03  ? 168  PHE A N   1 
ATOM   1325 C  CA  . PHE A 1 169 ? 37.857 -54.558 10.14   1    34.33  ? 168  PHE A CA  1 
ATOM   1326 C  C   . PHE A 1 169 ? 37.171 -53.172 10.115  1    33.5   ? 168  PHE A C   1 
ATOM   1327 O  O   . PHE A 1 169 ? 37.723 -52.218 9.581   1    33.21  ? 168  PHE A O   1 
ATOM   1328 C  CB  . PHE A 1 169 ? 37.198 -55.505 9.126   1    35.09  ? 168  PHE A CB  1 
ATOM   1329 C  CG  . PHE A 1 169 ? 37.207 -54.96  7.713   1    36.74  ? 168  PHE A CG  1 
ATOM   1330 C  CD1 . PHE A 1 169 ? 38.345 -55.048 6.925   1    38.33  ? 168  PHE A CD1 1 
ATOM   1331 C  CD2 . PHE A 1 169 ? 36.079 -54.364 7.172   1    37.68  ? 168  PHE A CD2 1 
ATOM   1332 C  CE1 . PHE A 1 169 ? 38.356 -54.535 5.626   1    39.39  ? 168  PHE A CE1 1 
ATOM   1333 C  CE2 . PHE A 1 169 ? 36.105 -53.816 5.894   1    38.85  ? 168  PHE A CE2 1 
ATOM   1334 C  CZ  . PHE A 1 169 ? 37.239 -53.92  5.121   1    39.16  ? 168  PHE A CZ  1 
ATOM   1335 N  N   . LEU A 1 170 ? 36.009 -53.06  10.769  1    32.8   ? 169  LEU A N   1 
ATOM   1336 C  CA  . LEU A 1 170 ? 35.275 -51.791 10.871  1    32.8   ? 169  LEU A CA  1 
ATOM   1337 C  C   . LEU A 1 170 ? 36.134 -50.711 11.551  1    33     ? 169  LEU A C   1 
ATOM   1338 O  O   . LEU A 1 170 ? 36.27  -49.603 11.031  1    32.77  ? 169  LEU A O   1 
ATOM   1339 C  CB  . LEU A 1 170 ? 33.963 -52.023 11.665  1    32.25  ? 169  LEU A CB  1 
ATOM   1340 C  CG  . LEU A 1 170 ? 33.228 -50.752 12.111  1    33.63  ? 169  LEU A CG  1 
ATOM   1341 C  CD1 . LEU A 1 170 ? 32.6   -50.034 10.897  1    33.44  ? 169  LEU A CD1 1 
ATOM   1342 C  CD2 . LEU A 1 170 ? 32.201 -51.076 13.18   1    34.69  ? 169  LEU A CD2 1 
ATOM   1343 N  N   . LEU A 1 171 ? 36.715 -51.024 12.723  1    33.52  ? 170  LEU A N   1 
ATOM   1344 C  CA  . LEU A 1 171 ? 37.564 -50.056 13.435  1    34.88  ? 170  LEU A CA  1 
ATOM   1345 C  C   . LEU A 1 171 ? 38.779 -49.615 12.638  1    35.56  ? 170  LEU A C   1 
ATOM   1346 O  O   . LEU A 1 171 ? 39.162 -48.445 12.698  1    36.3   ? 170  LEU A O   1 
ATOM   1347 C  CB  . LEU A 1 171 ? 37.992 -50.628 14.786  1    36.13  ? 170  LEU A CB  1 
ATOM   1348 C  CG  . LEU A 1 171 ? 36.845 -50.849 15.716  1    38.3   ? 170  LEU A CG  1 
ATOM   1349 C  CD1 . LEU A 1 171 ? 37.227 -51.801 16.811  1    39.63  ? 170  LEU A CD1 1 
ATOM   1350 C  CD2 . LEU A 1 171 ? 36.326 -49.523 16.259  1    38.98  ? 170  LEU A CD2 1 
ATOM   1351 N  N   . ASP A 1 172 ? 39.377 -50.535 11.873  1    35.51  ? 171  ASP A N   1 
ATOM   1352 C  CA  . ASP A 1 172 ? 40.52  -50.191 11.038  1    36.43  ? 171  ASP A CA  1 
ATOM   1353 C  C   . ASP A 1 172 ? 40.065 -49.251 9.918   1    35.88  ? 171  ASP A C   1 
ATOM   1354 O  O   . ASP A 1 172 ? 40.744 -48.272 9.613   1    36.23  ? 171  ASP A O   1 
ATOM   1355 C  CB  . ASP A 1 172 ? 41.161 -51.458 10.442  1    40.13  ? 171  ASP A CB  1 
ATOM   1356 C  CG  . ASP A 1 172 ? 42.447 -51.152 9.698   1    50.36  ? 171  ASP A CG  1 
ATOM   1357 O  OD1 . ASP A 1 172 ? 43.327 -50.459 10.279  1    52.49  ? 171  ASP A OD1 1 
ATOM   1358 O  OD2 . ASP A 1 172 ? 42.569 -51.574 8.529   1    54.73  ? 171  ASP A OD2 1 
ATOM   1359 N  N   . THR A 1 173 ? 38.899 -49.523 9.331   1    34.99  ? 172  THR A N   1 
ATOM   1360 C  CA  . THR A 1 173 ? 38.331 -48.692 8.276   1    34.73  ? 172  THR A CA  1 
ATOM   1361 C  C   . THR A 1 173 ? 38.035 -47.284 8.771   1    34.44  ? 172  THR A C   1 
ATOM   1362 O  O   . THR A 1 173 ? 38.372 -46.325 8.078   1    34.4   ? 172  THR A O   1 
ATOM   1363 C  CB  . THR A 1 173 ? 37.103 -49.386 7.693   1    35.42  ? 172  THR A CB  1 
ATOM   1364 O  OG1 . THR A 1 173 ? 37.507 -50.641 7.162   1    36.15  ? 172  THR A OG1 1 
ATOM   1365 C  CG2 . THR A 1 173 ? 36.446 -48.58  6.587   1    35.05  ? 172  THR A CG2 1 
ATOM   1366 N  N   . LEU A 1 174 ? 37.452 -47.162 9.987   1    34.37  ? 173  LEU A N   1 
ATOM   1367 C  CA  . LEU A 1 174 ? 37.095 -45.888 10.611  1    35.64  ? 173  LEU A CA  1 
ATOM   1368 C  C   . LEU A 1 174 ? 38.31  -45.128 11.163  1    38.84  ? 173  LEU A C   1 
ATOM   1369 O  O   . LEU A 1 174 ? 38.184 -43.945 11.462  1    39.76  ? 173  LEU A O   1 
ATOM   1370 C  CB  . LEU A 1 174 ? 36.106 -46.123 11.776  1    34.61  ? 173  LEU A CB  1 
ATOM   1371 C  CG  . LEU A 1 174 ? 34.713 -46.646 11.428  1    34.52  ? 173  LEU A CG  1 
ATOM   1372 C  CD1 . LEU A 1 174 ? 33.963 -47.1   12.707  1    34.4   ? 173  LEU A CD1 1 
ATOM   1373 C  CD2 . LEU A 1 174 ? 33.914 -45.598 10.618  1    34.05  ? 173  LEU A CD2 1 
ATOM   1374 N  N   . LYS A 1 175 ? 39.468 -45.806 11.35   1    40.73  ? 174  LYS A N   1 
ATOM   1375 C  CA  . LYS A 1 175 ? 40.687 -45.225 11.946  1    42.9   ? 174  LYS A CA  1 
ATOM   1376 C  C   . LYS A 1 175 ? 40.328 -44.68  13.341  1    44.52  ? 174  LYS A C   1 
ATOM   1377 O  O   . LYS A 1 175 ? 40.656 -43.543 13.661  1    45.56  ? 174  LYS A O   1 
ATOM   1378 C  CB  . LYS A 1 175 ? 41.307 -44.121 11.057  1    45.68  ? 174  LYS A CB  1 
ATOM   1379 C  CG  . LYS A 1 175 ? 41.346 -44.441 9.56    1    52.31  ? 174  LYS A CG  1 
ATOM   1380 C  CD  . LYS A 1 175 ? 42.748 -44.718 9.038   1    58.72  ? 174  LYS A CD  1 
ATOM   1381 C  CE  . LYS A 1 175 ? 43.09  -46.192 9.021   1    63.39  ? 174  LYS A CE  1 
ATOM   1382 N  NZ  . LYS A 1 175 ? 42.472 -46.898 7.858   1    66.06  ? 174  LYS A NZ  1 
ATOM   1383 N  N   . ALA A 1 176 ? 39.569 -45.462 14.122  1    45.06  ? 175  ALA A N   1 
ATOM   1384 C  CA  . ALA A 1 176 ? 39.103 -45.004 15.427  1    46.2   ? 175  ALA A CA  1 
ATOM   1385 C  C   . ALA A 1 176 ? 39.171 -46.072 16.493  1    46.82  ? 175  ALA A C   1 
ATOM   1386 O  O   . ALA A 1 176 ? 39.055 -47.259 16.195  1    46.99  ? 175  ALA A O   1 
ATOM   1387 C  CB  . ALA A 1 176 ? 37.663 -44.512 15.308  1    46.63  ? 175  ALA A CB  1 
ATOM   1388 N  N   . SER A 1 177 ? 39.322 -45.65  17.758  1    47.13  ? 176  SER A N   1 
ATOM   1389 C  CA  . SER A 1 177 ? 39.303 -46.59  18.878  1    48.21  ? 176  SER A CA  1 
ATOM   1390 C  C   . SER A 1 177 ? 37.833 -46.899 19.194  1    48.19  ? 176  SER A C   1 
ATOM   1391 O  O   . SER A 1 177 ? 36.947 -46.08  18.914  1    48.08  ? 176  SER A O   1 
ATOM   1392 C  CB  . SER A 1 177 ? 40.041 -46.018 20.09   1    50.64  ? 176  SER A CB  1 
ATOM   1393 O  OG  . SER A 1 177 ? 39.521 -44.761 20.492  1    54.3   ? 176  SER A OG  1 
ATOM   1394 N  N   . PRO A 1 178 ? 37.545 -48.096 19.726  1    47.92  ? 177  PRO A N   1 
ATOM   1395 C  CA  . PRO A 1 178 ? 36.146 -48.478 19.956  1    47.54  ? 177  PRO A CA  1 
ATOM   1396 C  C   . PRO A 1 178 ? 35.314 -47.527 20.808  1    47.11  ? 177  PRO A C   1 
ATOM   1397 O  O   . PRO A 1 178 ? 34.115 -47.422 20.553  1    47.24  ? 177  PRO A O   1 
ATOM   1398 C  CB  . PRO A 1 178 ? 36.249 -49.858 20.597  1    48.61  ? 177  PRO A CB  1 
ATOM   1399 C  CG  . PRO A 1 178 ? 37.577 -50.376 20.188  1    49.04  ? 177  PRO A CG  1 
ATOM   1400 C  CD  . PRO A 1 178 ? 38.473 -49.192 20.073  1    47.55  ? 177  PRO A CD  1 
ATOM   1401 N  N   . SER A 1 179 ? 35.917 -46.835 21.8    1    45.83  ? 178  SER A N   1 
ATOM   1402 C  CA  . SER A 1 179 ? 35.147 -45.905 22.641  1    45.31  ? 178  SER A CA  1 
ATOM   1403 C  C   . SER A 1 179 ? 34.724 -44.611 21.919  1    43.81  ? 178  SER A C   1 
ATOM   1404 O  O   . SER A 1 179 ? 33.939 -43.834 22.47   1    44.34  ? 178  SER A O   1 
ATOM   1405 C  CB  . SER A 1 179 ? 35.886 -45.588 23.94   1    47.02  ? 178  SER A CB  1 
ATOM   1406 O  OG  . SER A 1 179 ? 36.869 -44.583 23.75   1    50.56  ? 178  SER A OG  1 
ATOM   1407 N  N   . GLU A 1 180 ? 35.261 -44.362 20.716  1    41.96  ? 179  GLU A N   1 
ATOM   1408 C  CA  . GLU A 1 180 ? 34.898 -43.208 19.891  1    40.57  ? 179  GLU A CA  1 
ATOM   1409 C  C   . GLU A 1 180 ? 33.769 -43.561 18.875  1    37.91  ? 179  GLU A C   1 
ATOM   1410 O  O   . GLU A 1 180 ? 33.413 -42.719 18.06   1    37.59  ? 179  GLU A O   1 
ATOM   1411 C  CB  . GLU A 1 180 ? 36.118 -42.73  19.087  1    43.31  ? 179  GLU A CB  1 
ATOM   1412 C  CG  . GLU A 1 180 ? 37.252 -42.152 19.914  1    48.27  ? 179  GLU A CG  1 
ATOM   1413 C  CD  . GLU A 1 180 ? 38.468 -41.847 19.064  1    53.28  ? 179  GLU A CD  1 
ATOM   1414 O  OE1 . GLU A 1 180 ? 38.936 -42.775 18.368  1    55.1   ? 179  GLU A OE1 1 
ATOM   1415 O  OE2 . GLU A 1 180 ? 38.94  -40.687 19.074  1    55.76  ? 179  GLU A OE2 1 
ATOM   1416 N  N   . VAL A 1 181 ? 33.242 -44.791 18.906  1    36.28  ? 180  VAL A N   1 
ATOM   1417 C  CA  . VAL A 1 181 ? 32.22  -45.239 17.971  1    35.54  ? 180  VAL A CA  1 
ATOM   1418 C  C   . VAL A 1 181 ? 30.889 -45.569 18.658  1    34.92  ? 180  VAL A C   1 
ATOM   1419 O  O   . VAL A 1 181 ? 30.881 -46.247 19.692  1    34.84  ? 180  VAL A O   1 
ATOM   1420 C  CB  . VAL A 1 181 ? 32.745 -46.48  17.192  1    35.81  ? 180  VAL A CB  1 
ATOM   1421 C  CG1 . VAL A 1 181 ? 31.721 -47.006 16.183  1    36.34  ? 180  VAL A CG1 1 
ATOM   1422 C  CG2 . VAL A 1 181 ? 34.084 -46.187 16.51   1    35.75  ? 180  VAL A CG2 1 
ATOM   1423 N  N   . VAL A 1 182 ? 29.748 -45.106 18.054  1    33.57  ? 181  VAL A N   1 
ATOM   1424 C  CA  . VAL A 1 182 ? 28.375 -45.464 18.407  1    32.98  ? 181  VAL A CA  1 
ATOM   1425 C  C   . VAL A 1 182 ? 27.978 -46.466 17.34   1    32.05  ? 181  VAL A C   1 
ATOM   1426 O  O   . VAL A 1 182 ? 28.116 -46.182 16.151  1    32.94  ? 181  VAL A O   1 
ATOM   1427 C  CB  . VAL A 1 182 ? 27.304 -44.346 18.308  1    34.45  ? 181  VAL A CB  1 
ATOM   1428 C  CG1 . VAL A 1 182 ? 26.307 -44.409 19.44   1    34.88  ? 181  VAL A CG1 1 
ATOM   1429 C  CG2 . VAL A 1 182 ? 27.861 -42.955 18.05   1    34.95  ? 181  VAL A CG2 1 
ATOM   1430 N  N   . PHE A 1 183 ? 27.383 -47.564 17.728  1    30.42  ? 182  PHE A N   1 
ATOM   1431 C  CA  . PHE A 1 183 ? 27.021 -48.638 16.826  1    30.96  ? 182  PHE A CA  1 
ATOM   1432 C  C   . PHE A 1 183 ? 25.542 -49.002 17.031  1    30.6   ? 182  PHE A C   1 
ATOM   1433 O  O   . PHE A 1 183 ? 25.122 -49.357 18.133  1    31.07  ? 182  PHE A O   1 
ATOM   1434 C  CB  . PHE A 1 183 ? 27.964 -49.829 17.133  1    31.15  ? 182  PHE A CB  1 
ATOM   1435 C  CG  . PHE A 1 183 ? 27.859 -51.05  16.261  1    31.71  ? 182  PHE A CG  1 
ATOM   1436 C  CD1 . PHE A 1 183 ? 26.856 -51.976 16.46   1    32.36  ? 182  PHE A CD1 1 
ATOM   1437 C  CD2 . PHE A 1 183 ? 28.856 -51.354 15.348  1    32.44  ? 182  PHE A CD2 1 
ATOM   1438 C  CE1 . PHE A 1 183 ? 26.771 -53.114 15.679  1    33.1   ? 182  PHE A CE1 1 
ATOM   1439 C  CE2 . PHE A 1 183 ? 28.787 -52.511 14.595  1    32.95  ? 182  PHE A CE2 1 
ATOM   1440 C  CZ  . PHE A 1 183 ? 27.73  -53.369 14.748  1    33.49  ? 182  PHE A CZ  1 
ATOM   1441 N  N   . LEU A 1 184 ? 24.739 -48.887 15.972  1    29     ? 183  LEU A N   1 
ATOM   1442 C  CA  . LEU A 1 184 ? 23.299 -49.116 16.018  1    28.49  ? 183  LEU A CA  1 
ATOM   1443 C  C   . LEU A 1 184 ? 22.901 -50.353 15.269  1    29     ? 183  LEU A C   1 
ATOM   1444 O  O   . LEU A 1 184 ? 23.224 -50.507 14.086  1    29.14  ? 183  LEU A O   1 
ATOM   1445 C  CB  . LEU A 1 184 ? 22.56  -47.882 15.436  1    27.62  ? 183  LEU A CB  1 
ATOM   1446 C  CG  . LEU A 1 184 ? 22.732 -46.574 16.177  1    27.39  ? 183  LEU A CG  1 
ATOM   1447 C  CD1 . LEU A 1 184 ? 23.9   -45.754 15.605  1    27.89  ? 183  LEU A CD1 1 
ATOM   1448 C  CD2 . LEU A 1 184 ? 21.398 -45.741 16.1    1    28.68  ? 183  LEU A CD2 1 
ATOM   1449 N  N   . ASP A 1 185 ? 22.183 -51.256 15.937  1    28.51  ? 184  ASP A N   1 
ATOM   1450 C  CA  . ASP A 1 185 ? 21.776 -52.526 15.332  1    29.15  ? 184  ASP A CA  1 
ATOM   1451 C  C   . ASP A 1 185 ? 20.429 -52.973 15.895  1    30.11  ? 184  ASP A C   1 
ATOM   1452 O  O   . ASP A 1 185 ? 20.129 -52.655 17.043  1    31.05  ? 184  ASP A O   1 
ATOM   1453 C  CB  . ASP A 1 185 ? 22.85  -53.582 15.657  1    31.2   ? 184  ASP A CB  1 
ATOM   1454 C  CG  . ASP A 1 185 ? 22.965 -54.761 14.708  1    36.65  ? 184  ASP A CG  1 
ATOM   1455 O  OD1 . ASP A 1 185 ? 21.907 -55.327 14.32   1    37.61  ? 184  ASP A OD1 1 
ATOM   1456 O  OD2 . ASP A 1 185 ? 24.112 -55.121 14.348  1    38.94  ? 184  ASP A OD2 1 
ATOM   1457 N  N   . ASP A 1 186 ? 19.617 -53.677 15.105  1    29.6   ? 185  ASP A N   1 
ATOM   1458 C  CA  . ASP A 1 186 ? 18.321 -54.166 15.583  1    30.85  ? 185  ASP A CA  1 
ATOM   1459 C  C   . ASP A 1 186 ? 18.403 -55.621 16.115  1    34     ? 185  ASP A C   1 
ATOM   1460 O  O   . ASP A 1 186 ? 17.404 -56.122 16.641  1    35.01  ? 185  ASP A O   1 
ATOM   1461 C  CB  . ASP A 1 186 ? 17.231 -54.065 14.501  1    31.19  ? 185  ASP A CB  1 
ATOM   1462 C  CG  . ASP A 1 186 ? 17.491 -54.933 13.297  1    34.76  ? 185  ASP A CG  1 
ATOM   1463 O  OD1 . ASP A 1 186 ? 18.658 -55.039 12.895  1    36.67  ? 185  ASP A OD1 1 
ATOM   1464 O  OD2 . ASP A 1 186 ? 16.513 -55.502 12.742  1    37.11  ? 185  ASP A OD2 1 
ATOM   1465 N  N   . ILE A 1 187 ? 19.572 -56.303 15.95   1    34.36  ? 186  ILE A N   1 
ATOM   1466 C  CA  . ILE A 1 187 ? 19.758 -57.69  16.402  1    35.51  ? 186  ILE A CA  1 
ATOM   1467 C  C   . ILE A 1 187 ? 20.732 -57.697 17.577  1    35.49  ? 186  ILE A C   1 
ATOM   1468 O  O   . ILE A 1 187 ? 21.867 -57.254 17.451  1    34.86  ? 186  ILE A O   1 
ATOM   1469 C  CB  . ILE A 1 187 ? 20.191 -58.618 15.224  1    36.44  ? 186  ILE A CB  1 
ATOM   1470 C  CG1 . ILE A 1 187 ? 19.099 -58.666 14.139  1    38.32  ? 186  ILE A CG1 1 
ATOM   1471 C  CG2 . ILE A 1 187 ? 20.511 -60.035 15.739  1    37.19  ? 186  ILE A CG2 1 
ATOM   1472 C  CD1 . ILE A 1 187 ? 19.415 -59.589 12.862  1    40.52  ? 186  ILE A CD1 1 
ATOM   1473 N  N   . GLY A 1 188 ? 20.256 -58.114 18.749  1    35.89  ? 187  GLY A N   1 
ATOM   1474 C  CA  . GLY A 1 188 ? 21.062 -58.088 19.973  1    36.5   ? 187  GLY A CA  1 
ATOM   1475 C  C   . GLY A 1 188 ? 22.381 -58.843 19.931  1    36.72  ? 187  GLY A C   1 
ATOM   1476 O  O   . GLY A 1 188 ? 23.392 -58.365 20.442  1    36.74  ? 187  GLY A O   1 
ATOM   1477 N  N   . ALA A 1 189 ? 22.371 -60.004 19.295  1    37.82  ? 188  ALA A N   1 
ATOM   1478 C  CA  . ALA A 1 189 ? 23.536 -60.873 19.117  1    39.07  ? 188  ALA A CA  1 
ATOM   1479 C  C   . ALA A 1 189 ? 24.615 -60.171 18.271  1    39.75  ? 188  ALA A C   1 
ATOM   1480 O  O   . ALA A 1 189 ? 25.806 -60.385 18.495  1    40.14  ? 188  ALA A O   1 
ATOM   1481 C  CB  . ALA A 1 189 ? 23.105 -62.152 18.427  1    39.2   ? 188  ALA A CB  1 
ATOM   1482 N  N   . ASN A 1 190 ? 24.199 -59.347 17.28   1    38.92  ? 189  ASN A N   1 
ATOM   1483 C  CA  . ASN A 1 190 ? 25.18  -58.643 16.436  1    38.52  ? 189  ASN A CA  1 
ATOM   1484 C  C   . ASN A 1 190 ? 25.744 -57.377 17.091  1    37.75  ? 189  ASN A C   1 
ATOM   1485 O  O   . ASN A 1 190 ? 26.792 -56.859 16.699  1    37.81  ? 189  ASN A O   1 
ATOM   1486 C  CB  . ASN A 1 190 ? 24.586 -58.365 15.065  1    38.97  ? 189  ASN A CB  1 
ATOM   1487 C  CG  . ASN A 1 190 ? 24.271 -59.63  14.312  1    43.03  ? 189  ASN A CG  1 
ATOM   1488 O  OD1 . ASN A 1 190 ? 24.807 -60.715 14.603  1    44.49  ? 189  ASN A OD1 1 
ATOM   1489 N  ND2 . ASN A 1 190 ? 23.395 -59.536 13.322  1    44.13  ? 189  ASN A ND2 1 
ATOM   1490 N  N   . LEU A 1 191 ? 25.078 -56.902 18.127  1    36.76  ? 190  LEU A N   1 
ATOM   1491 C  CA  . LEU A 1 191 ? 25.484 -55.743 18.89   1    36.87  ? 190  LEU A CA  1 
ATOM   1492 C  C   . LEU A 1 191 ? 26.494 -56.138 19.996  1    36.82  ? 190  LEU A C   1 
ATOM   1493 O  O   . LEU A 1 191 ? 27.369 -55.359 20.351  1    36.4   ? 190  LEU A O   1 
ATOM   1494 C  CB  . LEU A 1 191 ? 24.169 -55.246 19.524  1    37.94  ? 190  LEU A CB  1 
ATOM   1495 C  CG  . LEU A 1 191 ? 24.058 -53.829 19.952  1    40.04  ? 190  LEU A CG  1 
ATOM   1496 C  CD1 . LEU A 1 191 ? 24.415 -52.87  18.81   1    40.44  ? 190  LEU A CD1 1 
ATOM   1497 C  CD2 . LEU A 1 191 ? 22.641 -53.569 20.361  1    40.98  ? 190  LEU A CD2 1 
ATOM   1498 N  N   . LYS A 1 192 ? 26.33  -57.342 20.56   1    37.73  ? 191  LYS A N   1 
ATOM   1499 C  CA  . LYS A 1 192 ? 27.157 -57.875 21.633  1    38.81  ? 191  LYS A CA  1 
ATOM   1500 C  C   . LYS A 1 192 ? 28.674 -57.773 21.361  1    38.63  ? 191  LYS A C   1 
ATOM   1501 O  O   . LYS A 1 192 ? 29.363 -57.201 22.205  1    39.35  ? 191  LYS A O   1 
ATOM   1502 C  CB  . LYS A 1 192 ? 26.718 -59.315 21.948  1    42.31  ? 191  LYS A CB  1 
ATOM   1503 C  CG  . LYS A 1 192 ? 27.367 -59.94  23.171  1    47.76  ? 191  LYS A CG  1 
ATOM   1504 C  CD  . LYS A 1 192 ? 26.772 -61.324 23.409  1    53.44  ? 191  LYS A CD  1 
ATOM   1505 C  CE  . LYS A 1 192 ? 27.848 -62.386 23.464  1    58.54  ? 191  LYS A CE  1 
ATOM   1506 N  NZ  . LYS A 1 192 ? 28.905 -62.042 24.457  1    61.03  ? 191  LYS A NZ  1 
ATOM   1507 N  N   . PRO A 1 193 ? 29.223 -58.208 20.186  1    37.44  ? 192  PRO A N   1 
ATOM   1508 C  CA  . PRO A 1 193 ? 30.676 -58.094 19.995  1    37.37  ? 192  PRO A CA  1 
ATOM   1509 C  C   . PRO A 1 193 ? 31.18  -56.668 20.01   1    37.19  ? 192  PRO A C   1 
ATOM   1510 O  O   . PRO A 1 193 ? 32.278 -56.428 20.473  1    37.4   ? 192  PRO A O   1 
ATOM   1511 C  CB  . PRO A 1 193 ? 30.928 -58.809 18.664  1    37.95  ? 192  PRO A CB  1 
ATOM   1512 C  CG  . PRO A 1 193 ? 29.739 -59.668 18.454  1    38.1   ? 192  PRO A CG  1 
ATOM   1513 C  CD  . PRO A 1 193 ? 28.599 -58.888 19.038  1    36.84  ? 192  PRO A CD  1 
ATOM   1514 N  N   . ALA A 1 194 ? 30.359 -55.697 19.542  1    37.02  ? 193  ALA A N   1 
ATOM   1515 C  CA  . ALA A 1 194 ? 30.783 -54.303 19.545  1    37.15  ? 193  ALA A CA  1 
ATOM   1516 C  C   . ALA A 1 194 ? 30.834 -53.757 20.98   1    37.26  ? 193  ALA A C   1 
ATOM   1517 O  O   . ALA A 1 194 ? 31.726 -52.988 21.314  1    36.52  ? 193  ALA A O   1 
ATOM   1518 C  CB  . ALA A 1 194 ? 29.833 -53.475 18.692  1    37.79  ? 193  ALA A CB  1 
ATOM   1519 N  N   . ARG A 1 195 ? 29.879 -54.152 21.821  1    38.7   ? 194  ARG A N   1 
ATOM   1520 C  CA  . ARG A 1 195 ? 29.873 -53.725 23.223  1    40.99  ? 194  ARG A CA  1 
ATOM   1521 C  C   . ARG A 1 195 ? 31.111 -54.301 23.947  1    42.36  ? 194  ARG A C   1 
ATOM   1522 O  O   . ARG A 1 195 ? 31.796 -53.552 24.639  1    42.24  ? 194  ARG A O   1 
ATOM   1523 C  CB  . ARG A 1 195 ? 28.589 -54.188 23.892  1    43.58  ? 194  ARG A CB  1 
ATOM   1524 C  CG  . ARG A 1 195 ? 28.391 -53.687 25.323  1    48.47  ? 194  ARG A CG  1 
ATOM   1525 C  CD  . ARG A 1 195 ? 26.979 -53.988 25.825  1    52.35  ? 194  ARG A CD  1 
ATOM   1526 N  NE  . ARG A 1 195 ? 26.547 -55.37  25.579  1    56.14  ? 194  ARG A NE  1 
ATOM   1527 C  CZ  . ARG A 1 195 ? 25.642 -55.721 24.668  1    58.99  ? 194  ARG A CZ  1 
ATOM   1528 N  NH1 . ARG A 1 195 ? 25.039 -54.797 23.932  1    59.59  ? 194  ARG A NH1 1 
ATOM   1529 N  NH2 . ARG A 1 195 ? 25.306 -56.996 24.515  1    58.71  ? 194  ARG A NH2 1 
ATOM   1530 N  N   . ASP A 1 196 ? 31.48  -55.574 23.669  1    43.63  ? 195  ASP A N   1 
ATOM   1531 C  CA  . ASP A 1 196 ? 32.691 -56.21  24.253  1    44.74  ? 195  ASP A CA  1 
ATOM   1532 C  C   . ASP A 1 196 ? 33.974 -55.435 23.942  1    44.57  ? 195  ASP A C   1 
ATOM   1533 O  O   . ASP A 1 196 ? 34.872 -55.379 24.78   1    44.53  ? 195  ASP A O   1 
ATOM   1534 C  CB  . ASP A 1 196 ? 32.869 -57.659 23.769  1    47.5   ? 195  ASP A CB  1 
ATOM   1535 C  CG  . ASP A 1 196 ? 31.752 -58.603 24.143  1    54.33  ? 195  ASP A CG  1 
ATOM   1536 O  OD1 . ASP A 1 196 ? 30.921 -58.231 25.003  1    55.55  ? 195  ASP A OD1 1 
ATOM   1537 O  OD2 . ASP A 1 196 ? 31.698 -59.713 23.567  1    57.68  ? 195  ASP A OD2 1 
ATOM   1538 N  N   . LEU A 1 197 ? 34.062 -54.821 22.747  1    43.79  ? 196  LEU A N   1 
ATOM   1539 C  CA  . LEU A 1 197 ? 35.228 -54.006 22.401  1    43.88  ? 196  LEU A CA  1 
ATOM   1540 C  C   . LEU A 1 197 ? 35.267 -52.655 23.103  1    43.95  ? 196  LEU A C   1 
ATOM   1541 O  O   . LEU A 1 197 ? 36.305 -52.002 23.1    1    44.28  ? 196  LEU A O   1 
ATOM   1542 C  CB  . LEU A 1 197 ? 35.293 -53.778 20.888  1    44.47  ? 196  LEU A CB  1 
ATOM   1543 C  CG  . LEU A 1 197 ? 35.854 -54.929 20.105  1    46.65  ? 196  LEU A CG  1 
ATOM   1544 C  CD1 . LEU A 1 197 ? 35.384 -54.877 18.671  1    47.39  ? 196  LEU A CD1 1 
ATOM   1545 C  CD2 . LEU A 1 197 ? 37.365 -54.952 20.206  1    47.64  ? 196  LEU A CD2 1 
ATOM   1546 N  N   . GLY A 1 198 ? 34.124 -52.207 23.627  1    43.78  ? 197  GLY A N   1 
ATOM   1547 C  CA  . GLY A 1 198 ? 34.001 -50.923 24.295  1    43.39  ? 197  GLY A CA  1 
ATOM   1548 C  C   . GLY A 1 198 ? 33.247 -49.881 23.489  1    42.48  ? 197  GLY A C   1 
ATOM   1549 O  O   . GLY A 1 198 ? 33.363 -48.683 23.774  1    43.02  ? 197  GLY A O   1 
ATOM   1550 N  N   . MET A 1 199 ? 32.517 -50.316 22.444  1    41.02  ? 198  MET A N   1 
ATOM   1551 C  CA  . MET A 1 199 ? 31.762 -49.359 21.629  1    39.67  ? 198  MET A CA  1 
ATOM   1552 C  C   . MET A 1 199 ? 30.485 -48.993 22.343  1    37.95  ? 198  MET A C   1 
ATOM   1553 O  O   . MET A 1 199 ? 29.88  -49.843 23.006  1    37.51  ? 198  MET A O   1 
ATOM   1554 C  CB  . MET A 1 199 ? 31.393 -49.955 20.251  1    40.08  ? 198  MET A CB  1 
ATOM   1555 C  CG  . MET A 1 199 ? 32.586 -50.272 19.353  1    42.02  ? 198  MET A CG  1 
ATOM   1556 S  SD  . MET A 1 199 ? 32.05  -50.568 17.63   1    44.5   ? 198  MET A SD  1 
ATOM   1557 C  CE  . MET A 1 199 ? 33.15  -51.997 17.167  1    44.87  ? 198  MET A CE  1 
ATOM   1558 N  N   . VAL A 1 200 ? 30.006 -47.754 22.13   1    37.15  ? 199  VAL A N   1 
ATOM   1559 C  CA  . VAL A 1 200 ? 28.683 -47.373 22.621  1    35.77  ? 199  VAL A CA  1 
ATOM   1560 C  C   . VAL A 1 200 ? 27.708 -48.052 21.65   1    35.1   ? 199  VAL A C   1 
ATOM   1561 O  O   . VAL A 1 200 ? 27.939 -48.051 20.427  1    35.64  ? 199  VAL A O   1 
ATOM   1562 C  CB  . VAL A 1 200 ? 28.501 -45.841 22.638  1    37.02  ? 199  VAL A CB  1 
ATOM   1563 C  CG1 . VAL A 1 200 ? 27.045 -45.465 22.935  1    37.73  ? 199  VAL A CG1 1 
ATOM   1564 C  CG2 . VAL A 1 200 ? 29.442 -45.195 23.641  1    37.81  ? 199  VAL A CG2 1 
ATOM   1565 N  N   . THR A 1 201 ? 26.711 -48.745 22.173  1    33.64  ? 200  THR A N   1 
ATOM   1566 C  CA  . THR A 1 201 ? 25.785 -49.497 21.349  1    33.6   ? 200  THR A CA  1 
ATOM   1567 C  C   . THR A 1 201 ? 24.349 -49.101 21.598  1    33.75  ? 200  THR A C   1 
ATOM   1568 O  O   . THR A 1 201 ? 23.969 -48.757 22.727  1    34.39  ? 200  THR A O   1 
ATOM   1569 C  CB  . THR A 1 201 ? 25.975 -50.999 21.562  1    35.08  ? 200  THR A CB  1 
ATOM   1570 O  OG1 . THR A 1 201 ? 25.651 -51.331 22.93   1    36.14  ? 200  THR A OG1 1 
ATOM   1571 C  CG2 . THR A 1 201 ? 27.384 -51.452 21.2    1    34.28  ? 200  THR A CG2 1 
ATOM   1572 N  N   . ILE A 1 202 ? 23.548 -49.161 20.552  1    32.33  ? 201  ILE A N   1 
ATOM   1573 C  CA  . ILE A 1 202 ? 22.134 -48.86  20.651  1    31.82  ? 201  ILE A CA  1 
ATOM   1574 C  C   . ILE A 1 202 ? 21.365 -49.978 20.015  1    31.22  ? 201  ILE A C   1 
ATOM   1575 O  O   . ILE A 1 202 ? 21.565 -50.271 18.824  1    30.54  ? 201  ILE A O   1 
ATOM   1576 C  CB  . ILE A 1 202 ? 21.811 -47.482 20.001  1    32.55  ? 201  ILE A CB  1 
ATOM   1577 C  CG1 . ILE A 1 202 ? 22.532 -46.345 20.761  1    33.41  ? 201  ILE A CG1 1 
ATOM   1578 C  CG2 . ILE A 1 202 ? 20.308 -47.264 19.965  1    33.3   ? 201  ILE A CG2 1 
ATOM   1579 C  CD1 . ILE A 1 202 ? 22.496 -44.958 20.118  1    34.2   ? 201  ILE A CD1 1 
ATOM   1580 N  N   . LEU A 1 203 ? 20.48  -50.639 20.792  1    30.34  ? 202  LEU A N   1 
ATOM   1581 C  CA  . LEU A 1 203 ? 19.625 -51.702 20.295  1    31.28  ? 202  LEU A CA  1 
ATOM   1582 C  C   . LEU A 1 203 ? 18.387 -51.021 19.77   1    32.75  ? 202  LEU A C   1 
ATOM   1583 O  O   . LEU A 1 203 ? 17.666 -50.357 20.539  1    33.89  ? 202  LEU A O   1 
ATOM   1584 C  CB  . LEU A 1 203 ? 19.232 -52.698 21.416  1    31.93  ? 202  LEU A CB  1 
ATOM   1585 C  CG  . LEU A 1 203 ? 18.281 -53.808 20.973  1    33.94  ? 202  LEU A CG  1 
ATOM   1586 C  CD1 . LEU A 1 203 ? 18.947 -54.748 19.968  1    34.79  ? 202  LEU A CD1 1 
ATOM   1587 C  CD2 . LEU A 1 203 ? 17.76  -54.631 22.182  1    34.71  ? 202  LEU A CD2 1 
ATOM   1588 N  N   . VAL A 1 204 ? 18.172 -51.13  18.459  1    30.89  ? 203  VAL A N   1 
ATOM   1589 C  CA  . VAL A 1 204 ? 17.085 -50.468 17.766  1    30.25  ? 203  VAL A CA  1 
ATOM   1590 C  C   . VAL A 1 204 ? 15.841 -51.319 17.651  1    30.82  ? 203  VAL A C   1 
ATOM   1591 O  O   . VAL A 1 204 ? 15.832 -52.356 16.979  1    31.24  ? 203  VAL A O   1 
ATOM   1592 C  CB  . VAL A 1 204 ? 17.562 -49.989 16.352  1    29.34  ? 203  VAL A CB  1 
ATOM   1593 C  CG1 . VAL A 1 204 ? 16.418 -49.356 15.576  1    29.33  ? 203  VAL A CG1 1 
ATOM   1594 C  CG2 . VAL A 1 204 ? 18.751 -49.05  16.461  1    28.94  ? 203  VAL A CG2 1 
ATOM   1595 N  N   . GLN A 1 205 ? 14.739 -50.863 18.29   1    30.96  ? 204  GLN A N   1 
ATOM   1596 C  CA  . GLN A 1 205 ? 13.443 -51.489 18.073  1    31.9   ? 204  GLN A CA  1 
ATOM   1597 C  C   . GLN A 1 205 ? 12.653 -50.404 17.316  1    33.56  ? 204  GLN A C   1 
ATOM   1598 O  O   . GLN A 1 205 ? 12.735 -50.366 16.086  1    35.1   ? 204  GLN A O   1 
ATOM   1599 C  CB  . GLN A 1 205 ? 12.782 -51.943 19.382  1    33.69  ? 204  GLN A CB  1 
ATOM   1600 C  CG  . GLN A 1 205 ? 13.575 -53.059 20.042  1    38.65  ? 204  GLN A CG  1 
ATOM   1601 C  CD  . GLN A 1 205 ? 12.933 -53.572 21.316  1    45.45  ? 204  GLN A CD  1 
ATOM   1602 O  OE1 . GLN A 1 205 ? 11.938 -53.026 21.821  1    46.19  ? 204  GLN A OE1 1 
ATOM   1603 N  NE2 . GLN A 1 205 ? 13.52  -54.625 21.869  1    46.51  ? 204  GLN A NE2 1 
ATOM   1604 N  N   . ASP A 1 206 ? 12.048 -49.432 18.021  1    32.22  ? 205  ASP A N   1 
ATOM   1605 C  CA  . ASP A 1 206 ? 11.383 -48.315 17.342  1    31.74  ? 205  ASP A CA  1 
ATOM   1606 C  C   . ASP A 1 206 ? 12.408 -47.195 17.116  1    29.29  ? 205  ASP A C   1 
ATOM   1607 O  O   . ASP A 1 206 ? 13.265 -46.924 17.967  1    28.53  ? 205  ASP A O   1 
ATOM   1608 C  CB  . ASP A 1 206 ? 10.205 -47.79  18.165  1    33.66  ? 205  ASP A CB  1 
ATOM   1609 C  CG  . ASP A 1 206 ? 10.657 -47.327 19.517  1    36.23  ? 205  ASP A CG  1 
ATOM   1610 O  OD1 . ASP A 1 206 ? 11.148 -48.175 20.301  1    36.04  ? 205  ASP A OD1 1 
ATOM   1611 O  OD2 . ASP A 1 206 ? 10.588 -46.115 19.774  1    39.43  ? 205  ASP A OD2 1 
ATOM   1612 N  N   . THR A 1 207 ? 12.322 -46.541 15.952  1    28.26  ? 206  THR A N   1 
ATOM   1613 C  CA  . THR A 1 207 ? 13.27  -45.488 15.611  1    27.77  ? 206  THR A CA  1 
ATOM   1614 C  C   . THR A 1 207 ? 13.314 -44.353 16.607  1    27.56  ? 206  THR A C   1 
ATOM   1615 O  O   . THR A 1 207 ? 14.385 -43.869 16.959  1    26.76  ? 206  THR A O   1 
ATOM   1616 C  CB  . THR A 1 207 ? 12.94  -44.971 14.203  1    28.53  ? 206  THR A CB  1 
ATOM   1617 O  OG1 . THR A 1 207 ? 13.04  -46.077 13.308  1    29.4   ? 206  THR A OG1 1 
ATOM   1618 C  CG2 . THR A 1 207 ? 13.825 -43.809 13.797  1    30.06  ? 206  THR A CG2 1 
ATOM   1619 N  N   . ASP A 1 208 ? 12.139 -43.892 17.065  1    29.02  ? 207  ASP A N   1 
ATOM   1620 C  CA  . ASP A 1 208 ? 12.106 -42.758 17.987  1    29.61  ? 207  ASP A CA  1 
ATOM   1621 C  C   . ASP A 1 208 ? 12.931 -42.975 19.268  1    28.34  ? 207  ASP A C   1 
ATOM   1622 O  O   . ASP A 1 208 ? 13.69  -42.094 19.651  1    28.09  ? 207  ASP A O   1 
ATOM   1623 C  CB  . ASP A 1 208 ? 10.663 -42.414 18.324  1    33.93  ? 207  ASP A CB  1 
ATOM   1624 C  CG  . ASP A 1 208 ? 10.539 -40.937 18.305  1    44.05  ? 207  ASP A CG  1 
ATOM   1625 O  OD1 . ASP A 1 208 ? 10.316 -40.372 17.194  1    45.01  ? 207  ASP A OD1 1 
ATOM   1626 O  OD2 . ASP A 1 208 ? 10.746 -40.326 19.371  1    48.71  ? 207  ASP A OD2 1 
ATOM   1627 N  N   . THR A 1 209 ? 12.835 -44.163 19.883  1    28.01  ? 208  THR A N   1 
ATOM   1628 C  CA  . THR A 1 209 ? 13.607 -44.434 21.116  1    29.37  ? 208  THR A CA  1 
ATOM   1629 C  C   . THR A 1 209 ? 15.091 -44.542 20.818  1    27.75  ? 208  THR A C   1 
ATOM   1630 O  O   . THR A 1 209 ? 15.926 -43.984 21.537  1    26.37  ? 208  THR A O   1 
ATOM   1631 C  CB  . THR A 1 209 ? 13.098 -45.692 21.78   1    32.54  ? 208  THR A CB  1 
ATOM   1632 O  OG1 . THR A 1 209 ? 11.695 -45.521 22.054  1    34.49  ? 208  THR A OG1 1 
ATOM   1633 C  CG2 . THR A 1 209 ? 13.886 -46.039 23.041  1    33.34  ? 208  THR A CG2 1 
ATOM   1634 N  N   . ALA A 1 210 ? 15.424 -45.198 19.693  1    28.55  ? 209  ALA A N   1 
ATOM   1635 C  CA  . ALA A 1 210 ? 16.83  -45.288 19.254  1    28.83  ? 209  ALA A CA  1 
ATOM   1636 C  C   . ALA A 1 210 ? 17.431 -43.885 19.053  1    28.77  ? 209  ALA A C   1 
ATOM   1637 O  O   . ALA A 1 210 ? 18.52  -43.604 19.549  1    28.99  ? 209  ALA A O   1 
ATOM   1638 C  CB  . ALA A 1 210 ? 16.92  -46.088 17.954  1    29.08  ? 209  ALA A CB  1 
ATOM   1639 N  N   . LEU A 1 211 ? 16.688 -42.962 18.4    1    28.79  ? 210  LEU A N   1 
ATOM   1640 C  CA  . LEU A 1 211 ? 17.21  -41.601 18.2    1    27.93  ? 210  LEU A CA  1 
ATOM   1641 C  C   . LEU A 1 211 ? 17.32  -40.793 19.501  1    27.94  ? 210  LEU A C   1 
ATOM   1642 O  O   . LEU A 1 211 ? 18.236 -39.987 19.658  1    27.39  ? 210  LEU A O   1 
ATOM   1643 C  CB  . LEU A 1 211 ? 16.395 -40.862 17.125  1    28.57  ? 210  LEU A CB  1 
ATOM   1644 C  CG  . LEU A 1 211 ? 16.469 -41.472 15.722  1    30.28  ? 210  LEU A CG  1 
ATOM   1645 C  CD1 . LEU A 1 211 ? 15.742 -40.554 14.701  1    31.25  ? 210  LEU A CD1 1 
ATOM   1646 C  CD2 . LEU A 1 211 ? 17.934 -41.631 15.248  1    30.55  ? 210  LEU A CD2 1 
ATOM   1647 N  N   . LYS A 1 212 ? 16.442 -41.07  20.485  1    28.41  ? 211  LYS A N   1 
ATOM   1648 C  CA  . LYS A 1 212 ? 16.542 -40.412 21.796  1    29.47  ? 211  LYS A CA  1 
ATOM   1649 C  C   . LYS A 1 212 ? 17.86  -40.862 22.457  1    28.76  ? 211  LYS A C   1 
ATOM   1650 O  O   . LYS A 1 212 ? 18.592 -40.026 22.983  1    28.93  ? 211  LYS A O   1 
ATOM   1651 C  CB  . LYS A 1 212 ? 15.359 -40.803 22.706  1    32.45  ? 211  LYS A CB  1 
ATOM   1652 C  CG  . LYS A 1 212 ? 14.029 -40.191 22.301  1    40.16  ? 211  LYS A CG  1 
ATOM   1653 C  CD  . LYS A 1 212 ? 12.967 -40.421 23.389  1    46.46  ? 211  LYS A CD  1 
ATOM   1654 C  CE  . LYS A 1 212 ? 11.617 -39.831 23.023  1    52.27  ? 211  LYS A CE  1 
ATOM   1655 N  NZ  . LYS A 1 212 ? 10.622 -40.014 24.126  1    55.43  ? 211  LYS A NZ  1 
ATOM   1656 N  N   . GLU A 1 213 ? 18.184 -42.178 22.362  1    29.12  ? 212  GLU A N   1 
ATOM   1657 C  CA  . GLU A 1 213 ? 19.443 -42.691 22.923  1    29.78  ? 212  GLU A CA  1 
ATOM   1658 C  C   . GLU A 1 213 ? 20.643 -42.083 22.194  1    29.87  ? 212  GLU A C   1 
ATOM   1659 O  O   . GLU A 1 213 ? 21.611 -41.655 22.822  1    30.02  ? 212  GLU A O   1 
ATOM   1660 C  CB  . GLU A 1 213 ? 19.512 -44.234 22.828  1    31.01  ? 212  GLU A CB  1 
ATOM   1661 C  CG  . GLU A 1 213 ? 18.411 -44.974 23.573  1    34.31  ? 212  GLU A CG  1 
ATOM   1662 C  CD  . GLU A 1 213 ? 18.631 -46.474 23.655  1    37.45  ? 212  GLU A CD  1 
ATOM   1663 O  OE1 . GLU A 1 213 ? 19.807 -46.905 23.569  1    38.6   ? 212  GLU A OE1 1 
ATOM   1664 O  OE2 . GLU A 1 213 ? 17.633 -47.219 23.8    1    35.37  ? 212  GLU A OE2 1 
ATOM   1665 N  N   . LEU A 1 214 ? 20.55  -41.994 20.847  1    29.76  ? 213  LEU A N   1 
ATOM   1666 C  CA  . LEU A 1 214 ? 21.636 -41.46  20.027  1    29.47  ? 213  LEU A CA  1 
ATOM   1667 C  C   . LEU A 1 214 ? 21.884 -40.004 20.332  1    30.49  ? 213  LEU A C   1 
ATOM   1668 O  O   . LEU A 1 214 ? 23.016 -39.569 20.413  1    30.44  ? 213  LEU A O   1 
ATOM   1669 C  CB  . LEU A 1 214 ? 21.3   -41.661 18.529  1    28.97  ? 213  LEU A CB  1 
ATOM   1670 C  CG  . LEU A 1 214 ? 22.387 -41.251 17.531  1    29.51  ? 213  LEU A CG  1 
ATOM   1671 C  CD1 . LEU A 1 214 ? 23.702 -42     17.793  1    29.66  ? 213  LEU A CD1 1 
ATOM   1672 C  CD2 . LEU A 1 214 ? 21.92  -41.509 16.106  1    30.33  ? 213  LEU A CD2 1 
ATOM   1673 N  N   . GLU A 1 215 ? 20.815 -39.235 20.527  1    31.46  ? 214  GLU A N   1 
ATOM   1674 C  CA  . GLU A 1 215 ? 20.893 -37.82  20.838  1    32.44  ? 214  GLU A CA  1 
ATOM   1675 C  C   . GLU A 1 215 ? 21.552 -37.617 22.212  1    33.45  ? 214  GLU A C   1 
ATOM   1676 O  O   . GLU A 1 215 ? 22.406 -36.752 22.373  1    33.35  ? 214  GLU A O   1 
ATOM   1677 C  CB  . GLU A 1 215 ? 19.446 -37.286 20.832  1    35.16  ? 214  GLU A CB  1 
ATOM   1678 C  CG  . GLU A 1 215 ? 19.235 -35.821 21.089  1    39.82  ? 214  GLU A CG  1 
ATOM   1679 C  CD  . GLU A 1 215 ? 17.798 -35.49  20.726  1    43.67  ? 214  GLU A CD  1 
ATOM   1680 O  OE1 . GLU A 1 215 ? 16.88  -35.938 21.456  1    45.63  ? 214  GLU A OE1 1 
ATOM   1681 O  OE2 . GLU A 1 215 ? 17.588 -34.856 19.668  1    41.59  ? 214  GLU A OE2 1 
ATOM   1682 N  N   . LYS A 1 216 ? 21.161 -38.418 23.191  1    34.27  ? 215  LYS A N   1 
ATOM   1683 C  CA  . LYS A 1 216 ? 21.688 -38.313 24.539  1    36.08  ? 215  LYS A CA  1 
ATOM   1684 C  C   . LYS A 1 216 ? 23.162 -38.675 24.597  1    37.21  ? 215  LYS A C   1 
ATOM   1685 O  O   . LYS A 1 216 ? 23.935 -37.998 25.287  1    39     ? 215  LYS A O   1 
ATOM   1686 C  CB  . LYS A 1 216 ? 20.871 -39.191 25.501  1    39.14  ? 215  LYS A CB  1 
ATOM   1687 C  CG  . LYS A 1 216 ? 21.269 -38.994 26.958  1    46.78  ? 215  LYS A CG  1 
ATOM   1688 C  CD  . LYS A 1 216 ? 20.206 -39.51  27.927  1    53.81  ? 215  LYS A CD  1 
ATOM   1689 C  CE  . LYS A 1 216 ? 20.822 -40.061 29.197  1    59.36  ? 215  LYS A CE  1 
ATOM   1690 N  NZ  . LYS A 1 216 ? 21.968 -39.229 29.665  1    62.83  ? 215  LYS A NZ  1 
ATOM   1691 N  N   . VAL A 1 217 ? 23.569 -39.716 23.853  1    36.19  ? 216  VAL A N   1 
ATOM   1692 C  CA  . VAL A 1 217 ? 24.951 -40.156 23.921  1    35.88  ? 216  VAL A CA  1 
ATOM   1693 C  C   . VAL A 1 217 ? 25.873 -39.254 23.087  1    35.42  ? 216  VAL A C   1 
ATOM   1694 O  O   . VAL A 1 217 ? 27.014 -39.05  23.475  1    35.37  ? 216  VAL A O   1 
ATOM   1695 C  CB  . VAL A 1 217 ? 25.073 -41.671 23.611  1    36.52  ? 216  VAL A CB  1 
ATOM   1696 C  CG1 . VAL A 1 217 ? 25.292 -41.934 22.124  1    36.55  ? 216  VAL A CG1 1 
ATOM   1697 C  CG2 . VAL A 1 217 ? 26.171 -42.297 24.446  1    36.85  ? 216  VAL A CG2 1 
ATOM   1698 N  N   . THR A 1 218 ? 25.378 -38.64  21.987  1    34.72  ? 217  THR A N   1 
ATOM   1699 C  CA  . THR A 1 218 ? 26.223 -37.752 21.17   1    34.56  ? 217  THR A CA  1 
ATOM   1700 C  C   . THR A 1 218 ? 26.139 -36.274 21.562  1    35.27  ? 217  THR A C   1 
ATOM   1701 O  O   . THR A 1 218 ? 26.974 -35.48  21.134  1    36.15  ? 217  THR A O   1 
ATOM   1702 C  CB  . THR A 1 218 ? 25.851 -37.871 19.68   1    35.22  ? 217  THR A CB  1 
ATOM   1703 O  OG1 . THR A 1 218 ? 24.523 -37.348 19.486  1    36.29  ? 217  THR A OG1 1 
ATOM   1704 C  CG2 . THR A 1 218 ? 25.967 -39.298 19.152  1    34.65  ? 217  THR A CG2 1 
ATOM   1705 N  N   . GLY A 1 219 ? 25.084 -35.894 22.272  1    35.73  ? 218  GLY A N   1 
ATOM   1706 C  CA  . GLY A 1 219 ? 24.846 -34.503 22.657  1    36.76  ? 218  GLY A CA  1 
ATOM   1707 C  C   . GLY A 1 219 ? 24.42  -33.621 21.494  1    37.65  ? 218  GLY A C   1 
ATOM   1708 O  O   . GLY A 1 219 ? 24.492 -32.397 21.583  1    38.67  ? 218  GLY A O   1 
ATOM   1709 N  N   . ILE A 1 220 ? 23.988 -34.232 20.379  1    37.27  ? 219  ILE A N   1 
ATOM   1710 C  CA  . ILE A 1 220 ? 23.581 -33.498 19.181  1    37     ? 219  ILE A CA  1 
ATOM   1711 C  C   . ILE A 1 220 ? 22.079 -33.638 18.982  1    36.63  ? 219  ILE A C   1 
ATOM   1712 O  O   . ILE A 1 220 ? 21.551 -34.742 19.081  1    36.95  ? 219  ILE A O   1 
ATOM   1713 C  CB  . ILE A 1 220 ? 24.388 -34.012 17.961  1    37.46  ? 219  ILE A CB  1 
ATOM   1714 C  CG1 . ILE A 1 220 ? 25.878 -33.614 18.104  1    38.83  ? 219  ILE A CG1 1 
ATOM   1715 C  CG2 . ILE A 1 220 ? 23.786 -33.539 16.619  1    37.17  ? 219  ILE A CG2 1 
ATOM   1716 C  CD1 . ILE A 1 220 ? 26.775 -34.238 17.091  1    40.58  ? 219  ILE A CD1 1 
ATOM   1717 N  N   . GLN A 1 221 ? 21.394 -32.526 18.701  1    36.21  ? 220  GLN A N   1 
ATOM   1718 C  CA  . GLN A 1 221 ? 19.958 -32.569 18.447  1    35.83  ? 220  GLN A CA  1 
ATOM   1719 C  C   . GLN A 1 221 ? 19.665 -33.334 17.136  1    33.87  ? 220  GLN A C   1 
ATOM   1720 O  O   . GLN A 1 221 ? 20.144 -32.968 16.067  1    34.38  ? 220  GLN A O   1 
ATOM   1721 C  CB  . GLN A 1 221 ? 19.368 -31.141 18.44   1    38.82  ? 220  GLN A CB  1 
ATOM   1722 C  CG  . GLN A 1 221 ? 18.023 -31.062 17.715  1    46.07  ? 220  GLN A CG  1 
ATOM   1723 C  CD  . GLN A 1 221 ? 17.304 -29.749 17.784  1    54.05  ? 220  GLN A CD  1 
ATOM   1724 O  OE1 . GLN A 1 221 ? 16.076 -29.718 17.743  1    56.74  ? 220  GLN A OE1 1 
ATOM   1725 N  NE2 . GLN A 1 221 ? 18.031 -28.643 17.866  1    55.38  ? 220  GLN A NE2 1 
ATOM   1726 N  N   . LEU A 1 222 ? 18.916 -34.412 17.234  1    32.16  ? 221  LEU A N   1 
ATOM   1727 C  CA  . LEU A 1 222 ? 18.574 -35.241 16.079  1    33     ? 221  LEU A CA  1 
ATOM   1728 C  C   . LEU A 1 222 ? 17.067 -35.373 15.894  1    34.68  ? 221  LEU A C   1 
ATOM   1729 O  O   . LEU A 1 222 ? 16.606 -35.624 14.785  1    35.5   ? 221  LEU A O   1 
ATOM   1730 C  CB  . LEU A 1 222 ? 19.193 -36.646 16.224  1    32.4   ? 221  LEU A CB  1 
ATOM   1731 C  CG  . LEU A 1 222 ? 20.696 -36.639 16.395  1    33.03  ? 221  LEU A CG  1 
ATOM   1732 C  CD1 . LEU A 1 222 ? 21.205 -38.007 16.787  1    33.77  ? 221  LEU A CD1 1 
ATOM   1733 C  CD2 . LEU A 1 222 ? 21.393 -36.127 15.131  1    33.69  ? 221  LEU A CD2 1 
ATOM   1734 N  N   . LEU A 1 223 ? 16.31  -35.274 16.975  1    34.92  ? 222  LEU A N   1 
ATOM   1735 C  CA  . LEU A 1 223 ? 14.864 -35.412 16.922  1    35.66  ? 222  LEU A CA  1 
ATOM   1736 C  C   . LEU A 1 223 ? 14.206 -34.024 16.892  1    34.16  ? 222  LEU A C   1 
ATOM   1737 O  O   . LEU A 1 223 ? 14.795 -33.057 17.366  1    34.17  ? 222  LEU A O   1 
ATOM   1738 C  CB  . LEU A 1 223 ? 14.442 -36.186 18.196  1    37.65  ? 222  LEU A CB  1 
ATOM   1739 C  CG  . LEU A 1 223 ? 13.495 -37.396 18.043  1    41.12  ? 222  LEU A CG  1 
ATOM   1740 C  CD1 . LEU A 1 223 ? 13.723 -38.186 16.758  1    41.95  ? 222  LEU A CD1 1 
ATOM   1741 C  CD2 . LEU A 1 223 ? 13.622 -38.319 19.227  1    42.46  ? 222  LEU A CD2 1 
ATOM   1742 N  N   . ASN A 1 224 ? 13.023 -33.906 16.293  1    33.66  ? 223  ASN A N   1 
ATOM   1743 C  CA  . ASN A 1 224 ? 12.294 -32.623 16.285  1    33.83  ? 223  ASN A CA  1 
ATOM   1744 C  C   . ASN A 1 224 ? 13.007 -31.505 15.545  1    35.42  ? 223  ASN A C   1 
ATOM   1745 O  O   . ASN A 1 224 ? 12.706 -30.35  15.804  1    36.05  ? 223  ASN A O   1 
ATOM   1746 C  CB  . ASN A 1 224 ? 12.001 -32.167 17.744  1    33.61  ? 223  ASN A CB  1 
ATOM   1747 C  CG  . ASN A 1 224 ? 11.345 -33.239 18.57   1    35.48  ? 223  ASN A CG  1 
ATOM   1748 O  OD1 . ASN A 1 224 ? 10.514 -33.97  18.062  1    35.81  ? 223  ASN A OD1 1 
ATOM   1749 N  ND2 . ASN A 1 224 ? 11.758 -33.412 19.835  1    35.65  ? 223  ASN A ND2 1 
ATOM   1750 N  N   . THR A 1 225 ? 13.986 -31.818 14.673  1    36.14  ? 224  THR A N   1 
ATOM   1751 C  CA  . THR A 1 225 ? 14.792 -30.803 13.989  1    38.09  ? 224  THR A CA  1 
ATOM   1752 C  C   . THR A 1 225 ? 14.053 -30.082 12.851  1    38.75  ? 224  THR A C   1 
ATOM   1753 O  O   . THR A 1 225 ? 13.069 -30.599 12.325  1    38.99  ? 224  THR A O   1 
ATOM   1754 C  CB  . THR A 1 225 ? 16.041 -31.469 13.4    1    41.44  ? 224  THR A CB  1 
ATOM   1755 O  OG1 . THR A 1 225 ? 15.613 -32.504 12.521  1    44.36  ? 224  THR A OG1 1 
ATOM   1756 C  CG2 . THR A 1 225 ? 16.927 -32.04  14.448  1    42     ? 224  THR A CG2 1 
ATOM   1757 N  N   . PRO A 1 226 ? 14.53  -28.894 12.432  1    39.22  ? 225  PRO A N   1 
ATOM   1758 C  CA  . PRO A 1 226 ? 13.88  -28.225 11.284  1    40.65  ? 225  PRO A CA  1 
ATOM   1759 C  C   . PRO A 1 226 ? 13.996 -29.076 10.006  1    42.48  ? 225  PRO A C   1 
ATOM   1760 O  O   . PRO A 1 226 ? 14.889 -29.927 9.907   1    42.76  ? 225  PRO A O   1 
ATOM   1761 C  CB  . PRO A 1 226 ? 14.641 -26.905 11.139  1    41.28  ? 225  PRO A CB  1 
ATOM   1762 C  CG  . PRO A 1 226 ? 15.532 -26.781 12.336  1    41.29  ? 225  PRO A CG  1 
ATOM   1763 C  CD  . PRO A 1 226 ? 15.709 -28.152 12.918  1    39.26  ? 225  PRO A CD  1 
ATOM   1764 N  N   . ALA A 1 227 ? 13.082 -28.876 9.032   1    42.8   ? 226  ALA A N   1 
ATOM   1765 C  CA  . ALA A 1 227 ? 13.117 -29.623 7.764   1    43.47  ? 226  ALA A CA  1 
ATOM   1766 C  C   . ALA A 1 227 ? 14.433 -29.339 7.028   1    42.19  ? 226  ALA A C   1 
ATOM   1767 O  O   . ALA A 1 227 ? 14.819 -28.181 6.877   1    42.03  ? 226  ALA A O   1 
ATOM   1768 C  CB  . ALA A 1 227 ? 11.923 -29.239 6.889   1    44.31  ? 226  ALA A CB  1 
ATOM   1769 N  N   . PRO A 1 228 ? 15.221 -30.384 6.735   1    40.85  ? 227  PRO A N   1 
ATOM   1770 C  CA  . PRO A 1 228 ? 16.519 -30.149 6.08    1    39.44  ? 227  PRO A CA  1 
ATOM   1771 C  C   . PRO A 1 228 ? 16.374 -29.792 4.593   1    37.57  ? 227  PRO A C   1 
ATOM   1772 O  O   . PRO A 1 228 ? 15.355 -30.097 3.987   1    37.48  ? 227  PRO A O   1 
ATOM   1773 C  CB  . PRO A 1 228 ? 17.24  -31.488 6.251   1    40.73  ? 227  PRO A CB  1 
ATOM   1774 C  CG  . PRO A 1 228 ? 16.134 -32.493 6.235   1    41.86  ? 227  PRO A CG  1 
ATOM   1775 C  CD  . PRO A 1 228 ? 14.925 -31.821 6.882   1    40.61  ? 227  PRO A CD  1 
ATOM   1776 N  N   . LEU A 1 229 ? 17.406 -29.183 4.009   1    36.74  ? 228  LEU A N   1 
ATOM   1777 C  CA  . LEU A 1 229 ? 17.381 -28.859 2.57    1    35.81  ? 228  LEU A CA  1 
ATOM   1778 C  C   . LEU A 1 229 ? 17.464 -30.169 1.765   1    33.63  ? 228  LEU A C   1 
ATOM   1779 O  O   . LEU A 1 229 ? 18.075 -31.135 2.239   1    34.12  ? 228  LEU A O   1 
ATOM   1780 C  CB  . LEU A 1 229 ? 18.625 -28.007 2.245   1    36.61  ? 228  LEU A CB  1 
ATOM   1781 C  CG  . LEU A 1 229 ? 18.601 -26.571 2.752   1    39.25  ? 228  LEU A CG  1 
ATOM   1782 C  CD1 . LEU A 1 229 ? 19.955 -25.905 2.55    1    40.5   ? 228  LEU A CD1 1 
ATOM   1783 C  CD2 . LEU A 1 229 ? 17.494 -25.772 2.065   1    40.13  ? 228  LEU A CD2 1 
ATOM   1784 N  N   . PRO A 1 230 ? 16.999 -30.193 0.495   1    30.92  ? 229  PRO A N   1 
ATOM   1785 C  CA  . PRO A 1 230 ? 17.26  -31.37  -0.357  1    29.16  ? 229  PRO A CA  1 
ATOM   1786 C  C   . PRO A 1 230 ? 18.775 -31.545 -0.527  1    26.4   ? 229  PRO A C   1 
ATOM   1787 O  O   . PRO A 1 230 ? 19.544 -30.587 -0.332  1    25.21  ? 229  PRO A O   1 
ATOM   1788 C  CB  . PRO A 1 230 ? 16.644 -30.969 -1.717  1    30.47  ? 229  PRO A CB  1 
ATOM   1789 C  CG  . PRO A 1 230 ? 15.712 -29.853 -1.431  1    31.45  ? 229  PRO A CG  1 
ATOM   1790 C  CD  . PRO A 1 230 ? 16.339 -29.116 -0.266  1    29.86  ? 229  PRO A CD  1 
ATOM   1791 N  N   . THR A 1 231 ? 19.209 -32.755 -0.937  1    25.53  ? 230  THR A N   1 
ATOM   1792 C  CA  . THR A 1 231 ? 20.626 -33.064 -1.189  1    25.97  ? 230  THR A CA  1 
ATOM   1793 C  C   . THR A 1 231 ? 21.143 -32.114 -2.287  1    25.33  ? 230  THR A C   1 
ATOM   1794 O  O   . THR A 1 231 ? 20.417 -31.842 -3.236  1    25.3   ? 230  THR A O   1 
ATOM   1795 C  CB  . THR A 1 231 ? 20.741 -34.51  -1.762  1    28.2   ? 230  THR A CB  1 
ATOM   1796 O  OG1 . THR A 1 231 ? 20.204 -35.453 -0.838  1    30.01  ? 230  THR A OG1 1 
ATOM   1797 C  CG2 . THR A 1 231 ? 22.166 -34.9   -2.118  1    28.31  ? 230  THR A CG2 1 
ATOM   1798 N  N   . SER A 1 232 ? 22.364 -31.637 -2.156  1    25.16  ? 231  SER A N   1 
ATOM   1799 C  CA  . SER A 1 232 ? 22.939 -30.735 -3.15   1    26.29  ? 231  SER A CA  1 
ATOM   1800 C  C   . SER A 1 232 ? 24.008 -31.504 -4.006  1    28.94  ? 231  SER A C   1 
ATOM   1801 O  O   . SER A 1 232 ? 24.061 -32.733 -3.931  1    31.92  ? 231  SER A O   1 
ATOM   1802 C  CB  . SER A 1 232 ? 23.474 -29.49  -2.446  1    27.5   ? 231  SER A CB  1 
ATOM   1803 O  OG  . SER A 1 232 ? 24.015 -28.58  -3.383  1    28.74  ? 231  SER A OG  1 
ATOM   1804 N  N   . CYS A 1 233 ? 24.75  -30.839 -4.885  1    28.11  ? 232  CYS A N   1 
ATOM   1805 C  CA  . CYS A 1 233 ? 25.771 -31.501 -5.728  1    28.42  ? 232  CYS A CA  1 
ATOM   1806 C  C   . CYS A 1 233 ? 27.116 -31.075 -5.312  1    29.48  ? 232  CYS A C   1 
ATOM   1807 O  O   . CYS A 1 233 ? 27.338 -29.868 -5.175  1    30.17  ? 232  CYS A O   1 
ATOM   1808 C  CB  . CYS A 1 233 ? 25.583 -31.115 -7.194  1    27.76  ? 232  CYS A CB  1 
ATOM   1809 S  SG  . CYS A 1 233 ? 24.112 -31.797 -7.941  1    28.21  ? 232  CYS A SG  1 
ATOM   1810 N  N   . ASN A 1 234 ? 28.07  -32.011 -5.294  1    28.99  ? 233  ASN A N   1 
ATOM   1811 C  CA  . ASN A 1 234 ? 29.46  -31.649 -5.107  1    29.61  ? 233  ASN A CA  1 
ATOM   1812 C  C   . ASN A 1 234 ? 30.033 -31.7   -6.519  1    28.72  ? 233  ASN A C   1 
ATOM   1813 O  O   . ASN A 1 234 ? 30.035 -32.775 -7.128  1    27.55  ? 233  ASN A O   1 
ATOM   1814 C  CB  . ASN A 1 234 ? 30.195 -32.665 -4.209  1    33.29  ? 233  ASN A CB  1 
ATOM   1815 C  CG  . ASN A 1 234 ? 31.663 -32.341 -4.038  1    40.16  ? 233  ASN A CG  1 
ATOM   1816 O  OD1 . ASN A 1 234 ? 32.144 -31.261 -4.419  1    41.89  ? 233  ASN A OD1 1 
ATOM   1817 N  ND2 . ASN A 1 234 ? 32.421 -33.272 -3.454  1    42.45  ? 233  ASN A ND2 1 
ATOM   1818 N  N   . PRO A 1 235 ? 30.489 -30.561 -7.067  1    29.2   ? 234  PRO A N   1 
ATOM   1819 C  CA  . PRO A 1 235 ? 30.946 -30.543 -8.474  1    29.48  ? 234  PRO A CA  1 
ATOM   1820 C  C   . PRO A 1 235 ? 31.962 -31.603 -8.874  1    29.92  ? 234  PRO A C   1 
ATOM   1821 O  O   . PRO A 1 235 ? 31.85  -32.177 -9.96   1    29.31  ? 234  PRO A O   1 
ATOM   1822 C  CB  . PRO A 1 235 ? 31.526 -29.135 -8.638  1    30.74  ? 234  PRO A CB  1 
ATOM   1823 C  CG  . PRO A 1 235 ? 30.691 -28.312 -7.704  1    31.11  ? 234  PRO A CG  1 
ATOM   1824 C  CD  . PRO A 1 235 ? 30.479 -29.197 -6.49   1    29.09  ? 234  PRO A CD  1 
ATOM   1825 N  N   . SER A 1 236 ? 32.907 -31.924 -7.978  1    30.68  ? 235  SER A N   1 
ATOM   1826 C  CA  . SER A 1 236 ? 33.943 -32.924 -8.27   1    31.16  ? 235  SER A CA  1 
ATOM   1827 C  C   . SER A 1 236 ? 33.43  -34.374 -8.252  1    30.81  ? 235  SER A C   1 
ATOM   1828 O  O   . SER A 1 236 ? 34.129 -35.292 -8.719  1    32.45  ? 235  SER A O   1 
ATOM   1829 C  CB  . SER A 1 236 ? 35.105 -32.756 -7.289  1    32.89  ? 235  SER A CB  1 
ATOM   1830 O  OG  . SER A 1 236 ? 34.6   -33.025 -5.992  1    35.57  ? 235  SER A OG  1 
ATOM   1831 N  N   . ASP A 1 237 ? 32.217 -34.598 -7.752  1    29.01  ? 236  ASP A N   1 
ATOM   1832 C  CA  . ASP A 1 237 ? 31.61  -35.909 -7.759  1    28.75  ? 236  ASP A CA  1 
ATOM   1833 C  C   . ASP A 1 237 ? 30.672 -36.15  -8.952  1    27.05  ? 236  ASP A C   1 
ATOM   1834 O  O   . ASP A 1 237 ? 30.07  -37.215 -9.032  1    27.35  ? 236  ASP A O   1 
ATOM   1835 C  CB  . ASP A 1 237 ? 30.878 -36.145 -6.448  1    32.72  ? 236  ASP A CB  1 
ATOM   1836 C  CG  . ASP A 1 237 ? 31.841 -36.378 -5.287  1    41.92  ? 236  ASP A CG  1 
ATOM   1837 O  OD1 . ASP A 1 237 ? 33.003 -36.805 -5.543  1    43     ? 236  ASP A OD1 1 
ATOM   1838 O  OD2 . ASP A 1 237 ? 31.445 -36.121 -4.128  1    45.52  ? 236  ASP A OD2 1 
ATOM   1839 N  N   . MET A 1 238 ? 30.518 -35.159 -9.846  1    25.17  ? 237  MET A N   1 
ATOM   1840 C  CA  . MET A 1 238 ? 29.568 -35.28  -10.943 1    24.57  ? 237  MET A CA  1 
ATOM   1841 C  C   . MET A 1 238 ? 30.247 -35.787 -12.22  1    23.59  ? 237  MET A C   1 
ATOM   1842 O  O   . MET A 1 238 ? 31.454 -35.598 -12.398 1    23.59  ? 237  MET A O   1 
ATOM   1843 C  CB  . MET A 1 238 ? 28.911 -33.913 -11.27  1    25.32  ? 237  MET A CB  1 
ATOM   1844 C  CG  . MET A 1 238 ? 28.372 -33.133 -10.052 1    27.01  ? 237  MET A CG  1 
ATOM   1845 S  SD  . MET A 1 238 ? 27.2   -34.083 -9.068  1    30.21  ? 237  MET A SD  1 
ATOM   1846 C  CE  . MET A 1 238 ? 25.838 -34.291 -10.215 1    28     ? 237  MET A CE  1 
ATOM   1847 N  N   . SER A 1 239 ? 29.452 -36.343 -13.125 1    22.86  ? 238  SER A N   1 
ATOM   1848 C  CA  . SER A 1 239 ? 29.932 -36.712 -14.448 1    23.15  ? 238  SER A CA  1 
ATOM   1849 C  C   . SER A 1 239 ? 29.854 -35.405 -15.281 1    23.21  ? 238  SER A C   1 
ATOM   1850 O  O   . SER A 1 239 ? 28.785 -34.771 -15.31  1    24.23  ? 238  SER A O   1 
ATOM   1851 C  CB  . SER A 1 239 ? 29.018 -37.761 -15.068 1    25.01  ? 238  SER A CB  1 
ATOM   1852 O  OG  . SER A 1 239 ? 29.51  -38.153 -16.341 1    29.13  ? 238  SER A OG  1 
ATOM   1853 N  N   . HIS A 1 240 ? 30.96  -35.004 -15.937 1    20.63  ? 239  HIS A N   1 
ATOM   1854 C  CA  . HIS A 1 240 ? 31     -33.796 -16.768 1    20.58  ? 239  HIS A CA  1 
ATOM   1855 C  C   . HIS A 1 240 ? 31.083 -34.198 -18.232 1    21.45  ? 239  HIS A C   1 
ATOM   1856 O  O   . HIS A 1 240 ? 31.975 -34.961 -18.576 1    21.59  ? 239  HIS A O   1 
ATOM   1857 C  CB  . HIS A 1 240 ? 32.238 -32.943 -16.428 1    22.03  ? 239  HIS A CB  1 
ATOM   1858 C  CG  . HIS A 1 240 ? 32.115 -32.33  -15.051 1    24.62  ? 239  HIS A CG  1 
ATOM   1859 N  ND1 . HIS A 1 240 ? 31.583 -31.064 -14.879 1    27.18  ? 239  HIS A ND1 1 
ATOM   1860 C  CD2 . HIS A 1 240 ? 32.367 -32.875 -13.836 1    26.51  ? 239  HIS A CD2 1 
ATOM   1861 C  CE1 . HIS A 1 240 ? 31.562 -30.853 -13.56  1    28.4   ? 239  HIS A CE1 1 
ATOM   1862 N  NE2 . HIS A 1 240 ? 32.026 -31.911 -12.886 1    27.62  ? 239  HIS A NE2 1 
ATOM   1863 N  N   . GLY A 1 241 ? 30.177 -33.667 -19.048 1    20.27  ? 240  GLY A N   1 
ATOM   1864 C  CA  . GLY A 1 241 ? 30.096 -33.965 -20.469 1    20.14  ? 240  GLY A CA  1 
ATOM   1865 C  C   . GLY A 1 241 ? 30.355 -32.743 -21.316 1    20.58  ? 240  GLY A C   1 
ATOM   1866 O  O   . GLY A 1 241 ? 30.072 -31.605 -20.897 1    20.72  ? 240  GLY A O   1 
ATOM   1867 N  N   . TYR A 1 242 ? 30.9   -32.975 -22.527 1    19.25  ? 241  TYR A N   1 
ATOM   1868 C  CA  . TYR A 1 242 ? 31.284 -31.888 -23.423 1    20.01  ? 241  TYR A CA  1 
ATOM   1869 C  C   . TYR A 1 242 ? 30.911 -32.27  -24.844 1    20.81  ? 241  TYR A C   1 
ATOM   1870 O  O   . TYR A 1 242 ? 31.315 -33.34  -25.295 1    20.43  ? 241  TYR A O   1 
ATOM   1871 C  CB  . TYR A 1 242 ? 32.816 -31.668 -23.359 1    20.84  ? 241  TYR A CB  1 
ATOM   1872 C  CG  . TYR A 1 242 ? 33.299 -31.343 -21.964 1    21.36  ? 241  TYR A CG  1 
ATOM   1873 C  CD1 . TYR A 1 242 ? 33.551 -32.353 -21.042 1    22.99  ? 241  TYR A CD1 1 
ATOM   1874 C  CD2 . TYR A 1 242 ? 33.494 -30.025 -21.561 1    23.23  ? 241  TYR A CD2 1 
ATOM   1875 C  CE1 . TYR A 1 242 ? 33.908 -32.067 -19.736 1    23.6   ? 241  TYR A CE1 1 
ATOM   1876 C  CE2 . TYR A 1 242 ? 33.895 -29.723 -20.258 1    24.3   ? 241  TYR A CE2 1 
ATOM   1877 C  CZ  . TYR A 1 242 ? 34.109 -30.753 -19.353 1    24.87  ? 241  TYR A CZ  1 
ATOM   1878 O  OH  . TYR A 1 242 ? 34.487 -30.537 -18.053 1    26.7   ? 241  TYR A OH  1 
ATOM   1879 N  N   . VAL A 1 243 ? 30.18  -31.396 -25.548 1    20.65  ? 242  VAL A N   1 
ATOM   1880 C  CA  . VAL A 1 243 ? 29.764 -31.663 -26.919 1    21.68  ? 242  VAL A CA  1 
ATOM   1881 C  C   . VAL A 1 243 ? 30.166 -30.477 -27.777 1    22.49  ? 242  VAL A C   1 
ATOM   1882 O  O   . VAL A 1 243 ? 29.771 -29.364 -27.447 1    22.04  ? 242  VAL A O   1 
ATOM   1883 C  CB  . VAL A 1 243 ? 28.21  -31.83  -26.951 1    23.83  ? 242  VAL A CB  1 
ATOM   1884 C  CG1 . VAL A 1 243 ? 27.684 -31.859 -28.388 1    25.8   ? 242  VAL A CG1 1 
ATOM   1885 C  CG2 . VAL A 1 243 ? 27.78  -33.09  -26.194 1    25.32  ? 242  VAL A CG2 1 
ATOM   1886 N  N   . THR A 1 244 ? 30.865 -30.695 -28.92  1    22.85  ? 243  THR A N   1 
ATOM   1887 C  CA  . THR A 1 244 ? 31.16  -29.579 -29.834 1    24.05  ? 243  THR A CA  1 
ATOM   1888 C  C   . THR A 1 244 ? 29.974 -29.434 -30.769 1    25.18  ? 243  THR A C   1 
ATOM   1889 O  O   . THR A 1 244 ? 29.645 -30.384 -31.475 1    26.19  ? 243  THR A O   1 
ATOM   1890 C  CB  . THR A 1 244 ? 32.475 -29.85  -30.58  1    26.07  ? 243  THR A CB  1 
ATOM   1891 O  OG1 . THR A 1 244 ? 33.517 -29.899 -29.606 1    27.52  ? 243  THR A OG1 1 
ATOM   1892 C  CG2 . THR A 1 244 ? 32.785 -28.765 -31.601 1    27.03  ? 243  THR A CG2 1 
ATOM   1893 N  N   . VAL A 1 245 ? 29.281 -28.287 -30.739 1    25.37  ? 244  VAL A N   1 
ATOM   1894 C  CA  . VAL A 1 245 ? 28.114 -28.089 -31.593 1    26.52  ? 244  VAL A CA  1 
ATOM   1895 C  C   . VAL A 1 245 ? 28.463 -27.402 -32.93  1    28.81  ? 244  VAL A C   1 
ATOM   1896 O  O   . VAL A 1 245 ? 27.647 -27.413 -33.836 1    29.9   ? 244  VAL A O   1 
ATOM   1897 C  CB  . VAL A 1 245 ? 26.971 -27.39  -30.837 1    27.34  ? 244  VAL A CB  1 
ATOM   1898 C  CG1 . VAL A 1 245 ? 26.43  -28.307 -29.731 1    27.68  ? 244  VAL A CG1 1 
ATOM   1899 C  CG2 . VAL A 1 245 ? 27.425 -26.057 -30.261 1    27.92  ? 244  VAL A CG2 1 
ATOM   1900 N  N   . LYS A 1 246 ? 29.631 -26.791 -33.027 1    29.64  ? 245  LYS A N   1 
ATOM   1901 C  CA  . LYS A 1 246 ? 30.153 -26.152 -34.238 1    31.97  ? 245  LYS A CA  1 
ATOM   1902 C  C   . LYS A 1 246 ? 31.617 -25.813 -33.952 1    33.39  ? 245  LYS A C   1 
ATOM   1903 O  O   . LYS A 1 246 ? 32.025 -25.781 -32.787 1    31.47  ? 245  LYS A O   1 
ATOM   1904 C  CB  . LYS A 1 246 ? 29.328 -24.899 -34.624 1    35.58  ? 245  LYS A CB  1 
ATOM   1905 C  CG  . LYS A 1 246 ? 29.236 -23.862 -33.531 1    40.47  ? 245  LYS A CG  1 
ATOM   1906 C  CD  . LYS A 1 246 ? 28.458 -22.621 -33.969 1    45.69  ? 245  LYS A CD  1 
ATOM   1907 C  CE  . LYS A 1 246 ? 27.013 -22.901 -34.295 1    48.25  ? 245  LYS A CE  1 
ATOM   1908 N  NZ  . LYS A 1 246 ? 26.122 -21.815 -33.778 1    48.45  ? 245  LYS A NZ  1 
ATOM   1909 N  N   . PRO A 1 247 ? 32.464 -25.55  -34.98  1    35.86  ? 246  PRO A N   1 
ATOM   1910 C  CA  . PRO A 1 247 ? 33.877 -25.219 -34.69  1    36.76  ? 246  PRO A CA  1 
ATOM   1911 C  C   . PRO A 1 247 ? 33.975 -24.094 -33.665 1    37.3   ? 246  PRO A C   1 
ATOM   1912 O  O   . PRO A 1 247 ? 33.175 -23.169 -33.733 1    38.51  ? 246  PRO A O   1 
ATOM   1913 C  CB  . PRO A 1 247 ? 34.439 -24.736 -36.048 1    37.7   ? 246  PRO A CB  1 
ATOM   1914 C  CG  . PRO A 1 247 ? 33.417 -25.031 -37.058 1    37.89  ? 246  PRO A CG  1 
ATOM   1915 C  CD  . PRO A 1 247 ? 32.168 -25.544 -36.432 1    36.3   ? 246  PRO A CD  1 
ATOM   1916 N  N   . ARG A 1 248 ? 34.86  -24.202 -32.681 1    37.31  ? 247  ARG A N   1 
ATOM   1917 C  CA  . ARG A 1 248 ? 34.986 -23.147 -31.651 1    37.72  ? 247  ARG A CA  1 
ATOM   1918 C  C   . ARG A 1 248 ? 33.836 -23.091 -30.621 1    35.27  ? 247  ARG A C   1 
ATOM   1919 O  O   . ARG A 1 248 ? 33.946 -22.292 -29.696 1    36.46  ? 247  ARG A O   1 
ATOM   1920 C  CB  . ARG A 1 248 ? 35.139 -21.722 -32.262 1    41.64  ? 247  ARG A CB  1 
ATOM   1921 C  CG  . ARG A 1 248 ? 36.162 -21.539 -33.385 1    48.67  ? 247  ARG A CG  1 
ATOM   1922 C  CD  . ARG A 1 248 ? 36.087 -20.112 -33.933 1    54.21  ? 247  ARG A CD  1 
ATOM   1923 N  NE  . ARG A 1 248 ? 36.483 -19.128 -32.921 1    59.99  ? 247  ARG A NE  1 
ATOM   1924 C  CZ  . ARG A 1 248 ? 37.645 -18.481 -32.913 1    64.66  ? 247  ARG A CZ  1 
ATOM   1925 N  NH1 . ARG A 1 248 ? 38.528 -18.673 -33.888 1    64.75  ? 247  ARG A NH1 1 
ATOM   1926 N  NH2 . ARG A 1 248 ? 37.929 -17.625 -31.939 1    66.16  ? 247  ARG A NH2 1 
ATOM   1927 N  N   . VAL A 1 249 ? 32.711 -23.835 -30.802 1    31.54  ? 248  VAL A N   1 
ATOM   1928 C  CA  . VAL A 1 249 ? 31.633 -23.804 -29.797 1    28.61  ? 248  VAL A CA  1 
ATOM   1929 C  C   . VAL A 1 249 ? 31.383 -25.187 -29.188 1    24.85  ? 248  VAL A C   1 
ATOM   1930 O  O   . VAL A 1 249 ? 30.894 -26.095 -29.881 1    24.17  ? 248  VAL A O   1 
ATOM   1931 C  CB  . VAL A 1 249 ? 30.278 -23.2   -30.266 1    30.51  ? 248  VAL A CB  1 
ATOM   1932 C  CG1 . VAL A 1 249 ? 29.286 -23.167 -29.101 1    31.23  ? 248  VAL A CG1 1 
ATOM   1933 C  CG2 . VAL A 1 249 ? 30.456 -21.791 -30.835 1    32.19  ? 248  VAL A CG2 1 
ATOM   1934 N  N   A ARG A 1 250 ? 31.723 -25.351 -27.89  0.5  23     ? 249  ARG A N   1 
ATOM   1935 N  N   B ARG A 1 250 ? 31.673 -25.311 -27.913 0.5  22.99  ? 249  ARG A N   1 
ATOM   1936 C  CA  A ARG A 1 250 ? 31.595 -26.594 -27.117 0.5  22.8   ? 249  ARG A CA  1 
ATOM   1937 C  CA  B ARG A 1 250 ? 31.362 -26.519 -27.206 0.5  22.78  ? 249  ARG A CA  1 
ATOM   1938 C  C   A ARG A 1 250 ? 30.715 -26.343 -25.872 0.5  22.01  ? 249  ARG A C   1 
ATOM   1939 C  C   B ARG A 1 250 ? 30.446 -26.17  -26.052 0.5  21.89  ? 249  ARG A C   1 
ATOM   1940 O  O   A ARG A 1 250 ? 31.042 -25.448 -25.076 0.5  21.63  ? 249  ARG A O   1 
ATOM   1941 O  O   B ARG A 1 250 ? 30.457 -25.041 -25.522 0.5  21.23  ? 249  ARG A O   1 
ATOM   1942 C  CB  A ARG A 1 250 ? 33.005 -27.045 -26.678 0.5  25.01  ? 249  ARG A CB  1 
ATOM   1943 C  CB  B ARG A 1 250 ? 32.616 -27.244 -26.733 0.5  24.84  ? 249  ARG A CB  1 
ATOM   1944 C  CG  A ARG A 1 250 ? 33.069 -28.066 -25.544 0.5  28.11  ? 249  ARG A CG  1 
ATOM   1945 C  CG  B ARG A 1 250 ? 33.357 -26.596 -25.546 0.5  29.31  ? 249  ARG A CG  1 
ATOM   1946 C  CD  A ARG A 1 250 ? 34.462 -28.079 -24.907 0.5  30.17  ? 249  ARG A CD  1 
ATOM   1947 C  CD  B ARG A 1 250 ? 34.186 -27.591 -24.72  0.5  35.96  ? 249  ARG A CD  1 
ATOM   1948 N  NE  A ARG A 1 250 ? 34.581 -27.214 -23.72  0.5  31.91  ? 249  ARG A NE  1 
ATOM   1949 N  NE  B ARG A 1 250 ? 34.109 -28.956 -25.249 0.5  41.29  ? 249  ARG A NE  1 
ATOM   1950 C  CZ  A ARG A 1 250 ? 35.557 -27.33  -22.82  0.5  31.21  ? 249  ARG A CZ  1 
ATOM   1951 C  CZ  B ARG A 1 250 ? 35.051 -29.533 -25.982 0.5  45.08  ? 249  ARG A CZ  1 
ATOM   1952 N  NH1 A ARG A 1 250 ? 36.503 -28.248 -22.971 0.5  28.21  ? 249  ARG A NH1 1 
ATOM   1953 N  NH1 B ARG A 1 250 ? 36.204 -28.913 -26.203 0.5  44.82  ? 249  ARG A NH1 1 
ATOM   1954 N  NH2 A ARG A 1 250 ? 35.59  -26.531 -21.756 0.5  29.64  ? 249  ARG A NH2 1 
ATOM   1955 N  NH2 B ARG A 1 250 ? 34.871 -30.756 -26.455 0.5  45.83  ? 249  ARG A NH2 1 
ATOM   1956 N  N   . LEU A 1 251 ? 29.624 -27.131 -25.698 1    21.12  ? 250  LEU A N   1 
ATOM   1957 C  CA  . LEU A 1 251 ? 28.742 -26.984 -24.552 1    20.4   ? 250  LEU A CA  1 
ATOM   1958 C  C   . LEU A 1 251 ? 29.117 -28.027 -23.496 1    20.38  ? 250  LEU A C   1 
ATOM   1959 O  O   . LEU A 1 251 ? 29.372 -29.194 -23.821 1    20.8   ? 250  LEU A O   1 
ATOM   1960 C  CB  . LEU A 1 251 ? 27.281 -27.149 -24.971 1    20.44  ? 250  LEU A CB  1 
ATOM   1961 C  CG  . LEU A 1 251 ? 26.777 -26.083 -25.953 1    23.39  ? 250  LEU A CG  1 
ATOM   1962 C  CD1 . LEU A 1 251 ? 25.365 -26.349 -26.334 1    24.35  ? 250  LEU A CD1 1 
ATOM   1963 C  CD2 . LEU A 1 251 ? 26.933 -24.626 -25.367 1    25.96  ? 250  LEU A CD2 1 
ATOM   1964 N  N   . HIS A 1 252 ? 29.204 -27.581 -22.238 1    19.54  ? 251  HIS A N   1 
ATOM   1965 C  CA  . HIS A 1 252 ? 29.475 -28.436 -21.098 1    19.56  ? 251  HIS A CA  1 
ATOM   1966 C  C   . HIS A 1 252 ? 28.152 -28.678 -20.364 1    19.94  ? 251  HIS A C   1 
ATOM   1967 O  O   . HIS A 1 252 ? 27.294 -27.79  -20.288 1    20.18  ? 251  HIS A O   1 
ATOM   1968 C  CB  . HIS A 1 252 ? 30.505 -27.756 -20.146 1    20.41  ? 251  HIS A CB  1 
ATOM   1969 C  CG  . HIS A 1 252 ? 30.57  -28.334 -18.758 1    21.09  ? 251  HIS A CG  1 
ATOM   1970 N  ND1 . HIS A 1 252 ? 30.057 -27.633 -17.666 1    22.96  ? 251  HIS A ND1 1 
ATOM   1971 C  CD2 . HIS A 1 252 ? 31.068 -29.523 -18.32  1    22.17  ? 251  HIS A CD2 1 
ATOM   1972 C  CE1 . HIS A 1 252 ? 30.264 -28.411 -16.596 1    23.46  ? 251  HIS A CE1 1 
ATOM   1973 N  NE2 . HIS A 1 252 ? 30.852 -29.57  -16.937 1    23.22  ? 251  HIS A NE2 1 
ATOM   1974 N  N   . PHE A 1 253 ? 28.019 -29.865 -19.785 1    19.91  ? 252  PHE A N   1 
ATOM   1975 C  CA  . PHE A 1 253 ? 26.868 -30.212 -18.96  1    19.44  ? 252  PHE A CA  1 
ATOM   1976 C  C   . PHE A 1 253 ? 27.275 -31.231 -17.905 1    19.82  ? 252  PHE A C   1 
ATOM   1977 O  O   . PHE A 1 253 ? 28.306 -31.906 -18.027 1    20     ? 252  PHE A O   1 
ATOM   1978 C  CB  . PHE A 1 253 ? 25.695 -30.771 -19.787 1    18.52  ? 252  PHE A CB  1 
ATOM   1979 C  CG  . PHE A 1 253 ? 26.02  -32.061 -20.513 1    19.42  ? 252  PHE A CG  1 
ATOM   1980 C  CD1 . PHE A 1 253 ? 26.807 -32.055 -21.656 1    20.16  ? 252  PHE A CD1 1 
ATOM   1981 C  CD2 . PHE A 1 253 ? 25.533 -33.278 -20.053 1    20.28  ? 252  PHE A CD2 1 
ATOM   1982 C  CE1 . PHE A 1 253 ? 27.087 -33.243 -22.342 1    20.58  ? 252  PHE A CE1 1 
ATOM   1983 C  CE2 . PHE A 1 253 ? 25.833 -34.47  -20.729 1    20.82  ? 252  PHE A CE2 1 
ATOM   1984 C  CZ  . PHE A 1 253 ? 26.612 -34.442 -21.856 1    20.51  ? 252  PHE A CZ  1 
ATOM   1985 N  N   . VAL A 1 254 ? 26.495 -31.29  -16.846 1    19.18  ? 253  VAL A N   1 
ATOM   1986 C  CA  . VAL A 1 254 ? 26.662 -32.3   -15.79  1    19.24  ? 253  VAL A CA  1 
ATOM   1987 C  C   . VAL A 1 254 ? 25.51  -33.289 -16.037 1    19.71  ? 253  VAL A C   1 
ATOM   1988 O  O   . VAL A 1 254 ? 24.394 -32.865 -16.379 1    20.96  ? 253  VAL A O   1 
ATOM   1989 C  CB  . VAL A 1 254 ? 26.573 -31.594 -14.413 1    22.5   ? 253  VAL A CB  1 
ATOM   1990 C  CG1 . VAL A 1 254 ? 26.155 -32.555 -13.32  1    24.76  ? 253  VAL A CG1 1 
ATOM   1991 C  CG2 . VAL A 1 254 ? 27.92  -30.952 -14.086 1    23.46  ? 253  VAL A CG2 1 
ATOM   1992 N  N   . GLU A 1 255 ? 25.755 -34.589 -15.826 1    18.57  ? 254  GLU A N   1 
ATOM   1993 C  CA  . GLU A 1 255 ? 24.756 -35.592 -16.133 1    18.33  ? 254  GLU A CA  1 
ATOM   1994 C  C   . GLU A 1 255 ? 24.572 -36.553 -14.986 1    18.77  ? 254  GLU A C   1 
ATOM   1995 O  O   . GLU A 1 255 ? 25.561 -37.071 -14.466 1    19.84  ? 254  GLU A O   1 
ATOM   1996 C  CB  . GLU A 1 255 ? 25.252 -36.365 -17.375 1    21.75  ? 254  GLU A CB  1 
ATOM   1997 C  CG  . GLU A 1 255 ? 24.27  -37.385 -17.896 1    25.2   ? 254  GLU A CG  1 
ATOM   1998 C  CD  . GLU A 1 255 ? 24.742 -37.92  -19.241 1    28.52  ? 254  GLU A CD  1 
ATOM   1999 O  OE1 . GLU A 1 255 ? 25.965 -38.143 -19.412 1    26.9   ? 254  GLU A OE1 1 
ATOM   2000 O  OE2 . GLU A 1 255 ? 23.89  -38.079 -20.137 1    28.68  ? 254  GLU A OE2 1 
ATOM   2001 N  N   . LEU A 1 256 ? 23.339 -36.805 -14.605 1    17.99  ? 255  LEU A N   1 
ATOM   2002 C  CA  . LEU A 1 256 ? 23.072 -37.745 -13.496 1    18.89  ? 255  LEU A CA  1 
ATOM   2003 C  C   . LEU A 1 256 ? 21.726 -38.421 -13.702 1    20.56  ? 255  LEU A C   1 
ATOM   2004 O  O   . LEU A 1 256 ? 20.737 -37.74  -13.993 1    20.45  ? 255  LEU A O   1 
ATOM   2005 C  CB  . LEU A 1 256 ? 23.03  -36.943 -12.16  1    18.66  ? 255  LEU A CB  1 
ATOM   2006 C  CG  . LEU A 1 256 ? 22.821 -37.815 -10.891 1    20.19  ? 255  LEU A CG  1 
ATOM   2007 C  CD1 . LEU A 1 256 ? 24.116 -38.554 -10.535 1    19.93  ? 255  LEU A CD1 1 
ATOM   2008 C  CD2 . LEU A 1 256 ? 22.423 -36.897 -9.664  1    21.78  ? 255  LEU A CD2 1 
ATOM   2009 N  N   . GLY A 1 257 ? 21.692 -39.737 -13.487 1    20.92  ? 256  GLY A N   1 
ATOM   2010 C  CA  . GLY A 1 257 ? 20.446 -40.483 -13.53  1    21.41  ? 256  GLY A CA  1 
ATOM   2011 C  C   . GLY A 1 257 ? 20.174 -41.253 -14.799 1    21.81  ? 256  GLY A C   1 
ATOM   2012 O  O   . GLY A 1 257 ? 20.885 -41.107 -15.801 1    19.81  ? 256  GLY A O   1 
ATOM   2013 N  N   . SER A 1 258 ? 19.113 -42.057 -14.757 1    22.1   ? 257  SER A N   1 
ATOM   2014 C  CA  . SER A 1 258 ? 18.652 -42.805 -15.918 1    23.74  ? 257  SER A CA  1 
ATOM   2015 C  C   . SER A 1 258 ? 17.175 -42.541 -16.133 1    25.14  ? 257  SER A C   1 
ATOM   2016 O  O   . SER A 1 258 ? 16.44  -42.217 -15.178 1    24.6   ? 257  SER A O   1 
ATOM   2017 C  CB  . SER A 1 258 ? 18.909 -44.304 -15.744 1    26.67  ? 257  SER A CB  1 
ATOM   2018 O  OG  . SER A 1 258 ? 18.214 -44.817 -14.621 1    27.62  ? 257  SER A OG  1 
ATOM   2019 N  N   . GLY A 1 259 ? 16.718 -42.727 -17.372 1    25.25  ? 258  GLY A N   1 
ATOM   2020 C  CA  . GLY A 1 259 ? 15.316 -42.513 -17.694 1    25.47  ? 258  GLY A CA  1 
ATOM   2021 C  C   . GLY A 1 259 ? 15.17  -41.43  -18.746 1    25.36  ? 258  GLY A C   1 
ATOM   2022 O  O   . GLY A 1 259 ? 16.132 -41.13  -19.455 1    25.53  ? 258  GLY A O   1 
ATOM   2023 N  N   . PRO A 1 260 ? 13.967 -40.838 -18.86  1    25.44  ? 259  PRO A N   1 
ATOM   2024 C  CA  . PRO A 1 260 ? 13.755 -39.793 -19.881 1    25.56  ? 259  PRO A CA  1 
ATOM   2025 C  C   . PRO A 1 260 ? 14.711 -38.62  -19.671 1    24.27  ? 259  PRO A C   1 
ATOM   2026 O  O   . PRO A 1 260 ? 14.973 -38.26  -18.517 1    24.41  ? 259  PRO A O   1 
ATOM   2027 C  CB  . PRO A 1 260 ? 12.292 -39.399 -19.695 1    27.18  ? 259  PRO A CB  1 
ATOM   2028 C  CG  . PRO A 1 260 ? 11.646 -40.627 -19.032 1    28.23  ? 259  PRO A CG  1 
ATOM   2029 C  CD  . PRO A 1 260 ? 12.732 -41.131 -18.108 1    25.66  ? 259  PRO A CD  1 
ATOM   2030 N  N   . ALA A 1 261 ? 15.308 -38.107 -20.769 1    23.36  ? 260  ALA A N   1 
ATOM   2031 C  CA  . ALA A 1 261 ? 16.269 -36.987 -20.667 1    22.38  ? 260  ALA A CA  1 
ATOM   2032 C  C   . ALA A 1 261 ? 15.543 -35.684 -20.303 1    21.72  ? 260  ALA A C   1 
ATOM   2033 O  O   . ALA A 1 261 ? 14.52  -35.334 -20.907 1    21.9   ? 260  ALA A O   1 
ATOM   2034 C  CB  . ALA A 1 261 ? 17.023 -36.813 -21.978 1    22.24  ? 260  ALA A CB  1 
ATOM   2035 N  N   . VAL A 1 262 ? 16.091 -34.96  -19.324 1    20.93  ? 261  VAL A N   1 
ATOM   2036 C  CA  . VAL A 1 262 ? 15.584 -33.683 -18.829 1    21.29  ? 261  VAL A CA  1 
ATOM   2037 C  C   . VAL A 1 262 ? 16.737 -32.709 -18.881 1    21.78  ? 261  VAL A C   1 
ATOM   2038 O  O   . VAL A 1 262 ? 17.696 -32.864 -18.131 1    22.8   ? 261  VAL A O   1 
ATOM   2039 C  CB  . VAL A 1 262 ? 15.039 -33.811 -17.39  1    22.02  ? 261  VAL A CB  1 
ATOM   2040 C  CG1 . VAL A 1 262 ? 14.515 -32.464 -16.888 1    23.19  ? 261  VAL A CG1 1 
ATOM   2041 C  CG2 . VAL A 1 262 ? 13.965 -34.891 -17.308 1    23.77  ? 261  VAL A CG2 1 
ATOM   2042 N  N   . CYS A 1 263 ? 16.621 -31.701 -19.735 1    20.78  ? 262  CYS A N   1 
ATOM   2043 C  CA  A CYS A 1 263 ? 17.645 -30.699 -19.962 0.5  20.42  ? 262  CYS A CA  1 
ATOM   2044 C  CA  B CYS A 1 263 ? 17.64  -30.663 -19.974 0.5  21.65  ? 262  CYS A CA  1 
ATOM   2045 C  C   . CYS A 1 263 ? 17.305 -29.431 -19.159 1    21.12  ? 262  CYS A C   1 
ATOM   2046 O  O   . CYS A 1 263 ? 16.278 -28.793 -19.418 1    21.82  ? 262  CYS A O   1 
ATOM   2047 C  CB  A CYS A 1 263 ? 17.728 -30.405 -21.455 0.5  20.01  ? 262  CYS A CB  1 
ATOM   2048 C  CB  B CYS A 1 263 ? 17.716 -30.303 -21.457 0.5  24.24  ? 262  CYS A CB  1 
ATOM   2049 S  SG  A CYS A 1 263 ? 19.074 -29.306 -21.912 0.5  17.79  ? 262  CYS A SG  1 
ATOM   2050 S  SG  B CYS A 1 263 ? 18.639 -31.48  -22.464 0.5  32.68  ? 262  CYS A SG  1 
ATOM   2051 N  N   . LEU A 1 264 ? 18.136 -29.107 -18.197 1    19.84  ? 263  LEU A N   1 
ATOM   2052 C  CA  . LEU A 1 264 ? 17.954 -27.929 -17.331 1    18.88  ? 263  LEU A CA  1 
ATOM   2053 C  C   . LEU A 1 264 ? 18.764 -26.774 -17.888 1    19.97  ? 263  LEU A C   1 
ATOM   2054 O  O   . LEU A 1 264 ? 19.987 -26.915 -18.066 1    20.08  ? 263  LEU A O   1 
ATOM   2055 C  CB  . LEU A 1 264 ? 18.441 -28.276 -15.898 1    18.51  ? 263  LEU A CB  1 
ATOM   2056 C  CG  . LEU A 1 264 ? 17.78  -29.497 -15.26  1    19.62  ? 263  LEU A CG  1 
ATOM   2057 C  CD1 . LEU A 1 264 ? 18.309 -29.712 -13.813 1    20.46  ? 263  LEU A CD1 1 
ATOM   2058 C  CD2 . LEU A 1 264 ? 16.227 -29.404 -15.318 1    21.19  ? 263  LEU A CD2 1 
ATOM   2059 N  N   . CYS A 1 265 ? 18.109 -25.619 -18.102 1    19.28  ? 264  CYS A N   1 
ATOM   2060 C  CA  . CYS A 1 265 ? 18.706 -24.438 -18.742 1    19.42  ? 264  CYS A CA  1 
ATOM   2061 C  C   . CYS A 1 265 ? 18.626 -23.218 -17.794 1    19.63  ? 264  CYS A C   1 
ATOM   2062 O  O   . CYS A 1 265 ? 17.563 -22.655 -17.605 1    19.64  ? 264  CYS A O   1 
ATOM   2063 C  CB  . CYS A 1 265 ? 17.981 -24.157 -20.05  1    20.42  ? 264  CYS A CB  1 
ATOM   2064 S  SG  . CYS A 1 265 ? 18.065 -25.546 -21.23  1    23.61  ? 264  CYS A SG  1 
ATOM   2065 N  N   . HIS A 1 266 ? 19.744 -22.839 -17.212 1    19.63  ? 265  HIS A N   1 
ATOM   2066 C  CA  . HIS A 1 266 ? 19.813 -21.737 -16.27  1    19.63  ? 265  HIS A CA  1 
ATOM   2067 C  C   . HIS A 1 266 ? 19.661 -20.338 -16.912 1    20.08  ? 265  HIS A C   1 
ATOM   2068 O  O   . HIS A 1 266 ? 19.704 -20.186 -18.143 1    20.29  ? 265  HIS A O   1 
ATOM   2069 C  CB  . HIS A 1 266 ? 21.155 -21.803 -15.483 1    18.52  ? 265  HIS A CB  1 
ATOM   2070 C  CG  . HIS A 1 266 ? 22.382 -21.48  -16.303 1    18.93  ? 265  HIS A CG  1 
ATOM   2071 N  ND1 . HIS A 1 266 ? 22.676 -20.186 -16.697 1    20.6   ? 265  HIS A ND1 1 
ATOM   2072 C  CD2 . HIS A 1 266 ? 23.353 -22.314 -16.765 1    19.12  ? 265  HIS A CD2 1 
ATOM   2073 C  CE1 . HIS A 1 266 ? 23.823 -20.261 -17.374 1    21.44  ? 265  HIS A CE1 1 
ATOM   2074 N  NE2 . HIS A 1 266 ? 24.255 -21.527 -17.468 1    20.48  ? 265  HIS A NE2 1 
ATOM   2075 N  N   . GLY A 1 267 ? 19.547 -19.326 -16.035 1    20.07  ? 266  GLY A N   1 
ATOM   2076 C  CA  . GLY A 1 267 ? 19.415 -17.955 -16.477 1    22.06  ? 266  GLY A CA  1 
ATOM   2077 C  C   . GLY A 1 267 ? 20.661 -17.127 -16.24  1    22.56  ? 266  GLY A C   1 
ATOM   2078 O  O   . GLY A 1 267 ? 21.777 -17.654 -16.123 1    21.7   ? 266  GLY A O   1 
ATOM   2079 N  N   . PHE A 1 268 ? 20.466 -15.811 -16.215 1    21.8   ? 267  PHE A N   1 
ATOM   2080 C  CA  . PHE A 1 268 ? 21.561 -14.89  -16.041 1    21.44  ? 267  PHE A CA  1 
ATOM   2081 C  C   . PHE A 1 268 ? 21.67  -14.393 -14.593 1    21.8   ? 267  PHE A C   1 
ATOM   2082 O  O   . PHE A 1 268 ? 20.661 -13.915 -14.027 1    21.7   ? 267  PHE A O   1 
ATOM   2083 C  CB  . PHE A 1 268 ? 21.308 -13.649 -16.957 1    21.69  ? 267  PHE A CB  1 
ATOM   2084 C  CG  . PHE A 1 268 ? 22.306 -12.51  -16.78  1    23.12  ? 267  PHE A CG  1 
ATOM   2085 C  CD1 . PHE A 1 268 ? 22.147 -11.569 -15.765 1    24.6   ? 267  PHE A CD1 1 
ATOM   2086 C  CD2 . PHE A 1 268 ? 23.422 -12.414 -17.6   1    24.73  ? 267  PHE A CD2 1 
ATOM   2087 C  CE1 . PHE A 1 268 ? 23.084 -10.541 -15.591 1    26.11  ? 267  PHE A CE1 1 
ATOM   2088 C  CE2 . PHE A 1 268 ? 24.357 -11.388 -17.432 1    25.62  ? 267  PHE A CE2 1 
ATOM   2089 C  CZ  . PHE A 1 268 ? 24.187 -10.464 -16.421 1    25.6   ? 267  PHE A CZ  1 
ATOM   2090 N  N   . PRO A 1 269 ? 22.897 -14.272 -14.06  1    21.62  ? 268  PRO A N   1 
ATOM   2091 C  CA  . PRO A 1 269 ? 24.19  -14.771 -14.602 1    22.21  ? 268  PRO A CA  1 
ATOM   2092 C  C   . PRO A 1 269 ? 24.528 -16.018 -13.784 1    21.99  ? 268  PRO A C   1 
ATOM   2093 O  O   . PRO A 1 269 ? 25.092 -15.909 -12.694 1    22.59  ? 268  PRO A O   1 
ATOM   2094 C  CB  . PRO A 1 269 ? 25.156 -13.624 -14.258 1    23.65  ? 268  PRO A CB  1 
ATOM   2095 C  CG  . PRO A 1 269 ? 24.5   -12.912 -12.997 1    23.88  ? 268  PRO A CG  1 
ATOM   2096 C  CD  . PRO A 1 269 ? 23.119 -13.547 -12.784 1    21.77  ? 268  PRO A CD  1 
ATOM   2097 N  N   . GLU A 1 270 ? 24.075 -17.194 -14.242 1    21.25  ? 269  GLU A N   1 
ATOM   2098 C  CA  . GLU A 1 270 ? 24.144 -18.373 -13.402 1    21.62  ? 269  GLU A CA  1 
ATOM   2099 C  C   . GLU A 1 270 ? 25.078 -19.471 -13.963 1    22.13  ? 269  GLU A C   1 
ATOM   2100 O  O   . GLU A 1 270 ? 26.155 -19.157 -14.492 1    22.39  ? 269  GLU A O   1 
ATOM   2101 C  CB  . GLU A 1 270 ? 22.71  -18.848 -13.096 1    23.12  ? 269  GLU A CB  1 
ATOM   2102 C  CG  . GLU A 1 270 ? 21.948 -17.768 -12.343 1    25.97  ? 269  GLU A CG  1 
ATOM   2103 C  CD  . GLU A 1 270 ? 20.539 -18.191 -11.989 1    32.12  ? 269  GLU A CD  1 
ATOM   2104 O  OE1 . GLU A 1 270 ? 19.585 -17.596 -12.542 1    35.7   ? 269  GLU A OE1 1 
ATOM   2105 O  OE2 . GLU A 1 270 ? 20.388 -19.175 -11.232 1    31.52  ? 269  GLU A OE2 1 
ATOM   2106 N  N   . SER A 1 271 ? 24.724 -20.739 -13.753 1    20.56  ? 270  SER A N   1 
ATOM   2107 C  CA  . SER A 1 271 ? 25.597 -21.855 -13.992 1    20.23  ? 270  SER A CA  1 
ATOM   2108 C  C   . SER A 1 271 ? 24.746 -23.125 -13.964 1    19.7   ? 270  SER A C   1 
ATOM   2109 O  O   . SER A 1 271 ? 23.638 -23.115 -13.394 1    19.82  ? 270  SER A O   1 
ATOM   2110 C  CB  . SER A 1 271 ? 26.549 -21.912 -12.79  1    21.46  ? 270  SER A CB  1 
ATOM   2111 O  OG  . SER A 1 271 ? 27.25  -23.115 -12.586 1    22.88  ? 270  SER A OG  1 
ATOM   2112 N  N   . TRP A 1 272 ? 25.313 -24.266 -14.422 1    18.87  ? 271  TRP A N   1 
ATOM   2113 C  CA  . TRP A 1 272 ? 24.654 -25.562 -14.198 1    18.72  ? 271  TRP A CA  1 
ATOM   2114 C  C   . TRP A 1 272 ? 24.357 -25.756 -12.67  1    19.6   ? 271  TRP A C   1 
ATOM   2115 O  O   . TRP A 1 272 ? 23.353 -26.34  -12.292 1    21.06  ? 271  TRP A O   1 
ATOM   2116 C  CB  . TRP A 1 272 ? 25.558 -26.728 -14.665 1    18.31  ? 271  TRP A CB  1 
ATOM   2117 C  CG  . TRP A 1 272 ? 26.794 -26.99  -13.836 1    19.06  ? 271  TRP A CG  1 
ATOM   2118 C  CD1 . TRP A 1 272 ? 28.073 -26.561 -14.098 1    20.46  ? 271  TRP A CD1 1 
ATOM   2119 C  CD2 . TRP A 1 272 ? 26.883 -27.839 -12.679 1    19.98  ? 271  TRP A CD2 1 
ATOM   2120 N  NE1 . TRP A 1 272 ? 28.941 -27.052 -13.14  1    20.74  ? 271  TRP A NE1 1 
ATOM   2121 C  CE2 . TRP A 1 272 ? 28.233 -27.839 -12.258 1    20.45  ? 271  TRP A CE2 1 
ATOM   2122 C  CE3 . TRP A 1 272 ? 25.943 -28.569 -11.93  1    21.15  ? 271  TRP A CE3 1 
ATOM   2123 C  CZ2 . TRP A 1 272 ? 28.662 -28.552 -11.135 1    21.74  ? 271  TRP A CZ2 1 
ATOM   2124 C  CZ3 . TRP A 1 272 ? 26.369 -29.282 -10.818 1    22.14  ? 271  TRP A CZ3 1 
ATOM   2125 C  CH2 . TRP A 1 272 ? 27.706 -29.237 -10.407 1    22.26  ? 271  TRP A CH2 1 
ATOM   2126 N  N   . TYR A 1 273 ? 25.262 -25.204 -11.821 1    18.92  ? 272  TYR A N   1 
ATOM   2127 C  CA  . TYR A 1 273 ? 25.211 -25.312 -10.358 1    20     ? 272  TYR A CA  1 
ATOM   2128 C  C   . TYR A 1 273 ? 24.01  -24.636 -9.734  1    20.31  ? 272  TYR A C   1 
ATOM   2129 O  O   . TYR A 1 273 ? 23.661 -24.983 -8.595  1    20.85  ? 272  TYR A O   1 
ATOM   2130 C  CB  . TYR A 1 273 ? 26.516 -24.768 -9.8    1    20.31  ? 272  TYR A CB  1 
ATOM   2131 C  CG  . TYR A 1 273 ? 26.791 -25.045 -8.341  1    22.24  ? 272  TYR A CG  1 
ATOM   2132 C  CD1 . TYR A 1 273 ? 26.965 -26.338 -7.882  1    23.47  ? 272  TYR A CD1 1 
ATOM   2133 C  CD2 . TYR A 1 273 ? 26.966 -24.002 -7.438  1    24.22  ? 272  TYR A CD2 1 
ATOM   2134 C  CE1 . TYR A 1 273 ? 27.324 -26.594 -6.566  1    25.19  ? 272  TYR A CE1 1 
ATOM   2135 C  CE2 . TYR A 1 273 ? 27.343 -24.244 -6.128  1    25.97  ? 272  TYR A CE2 1 
ATOM   2136 C  CZ  . TYR A 1 273 ? 27.518 -25.539 -5.694  1    27.1   ? 272  TYR A CZ  1 
ATOM   2137 O  OH  . TYR A 1 273 ? 27.833 -25.772 -4.378  1    30.01  ? 272  TYR A OH  1 
ATOM   2138 N  N   . SER A 1 274 ? 23.317 -23.743 -10.481 1    19.87  ? 273  SER A N   1 
ATOM   2139 C  CA  . SER A 1 274 ? 22.076 -23.186 -9.977  1    21.2   ? 273  SER A CA  1 
ATOM   2140 C  C   . SER A 1 274 ? 21.005 -24.243 -9.793  1    20.86  ? 273  SER A C   1 
ATOM   2141 O  O   . SER A 1 274 ? 20.061 -23.996 -9.044  1    23.04  ? 273  SER A O   1 
ATOM   2142 C  CB  . SER A 1 274 ? 21.569 -22.087 -10.897 1    22.98  ? 273  SER A CB  1 
ATOM   2143 O  OG  . SER A 1 274 ? 22.418 -20.976 -10.69  1    27.94  ? 273  SER A OG  1 
ATOM   2144 N  N   . TRP A 1 275 ? 21.171 -25.441 -10.416 1    18.57  ? 274  TRP A N   1 
ATOM   2145 C  CA  . TRP A 1 275 ? 20.209 -26.542 -10.297 1    18.19  ? 274  TRP A CA  1 
ATOM   2146 C  C   . TRP A 1 275 ? 20.71  -27.586 -9.257  1    19.59  ? 274  TRP A C   1 
ATOM   2147 O  O   . TRP A 1 275 ? 20.188 -28.7   -9.245  1    19.56  ? 274  TRP A O   1 
ATOM   2148 C  CB  . TRP A 1 275 ? 20.051 -27.237 -11.689 1    17.74  ? 274  TRP A CB  1 
ATOM   2149 C  CG  . TRP A 1 275 ? 19.543 -26.324 -12.779 1    19.27  ? 274  TRP A CG  1 
ATOM   2150 C  CD1 . TRP A 1 275 ? 20.275 -25.736 -13.777 1    19.27  ? 274  TRP A CD1 1 
ATOM   2151 C  CD2 . TRP A 1 275 ? 18.178 -25.954 -13.009 1    19.44  ? 274  TRP A CD2 1 
ATOM   2152 N  NE1 . TRP A 1 275 ? 19.448 -24.98  -14.585 1    20.13  ? 274  TRP A NE1 1 
ATOM   2153 C  CE2 . TRP A 1 275 ? 18.158 -25.082 -14.12  1    19.71  ? 274  TRP A CE2 1 
ATOM   2154 C  CE3 . TRP A 1 275 ? 16.978 -26.191 -12.312 1    19.81  ? 274  TRP A CE3 1 
ATOM   2155 C  CZ2 . TRP A 1 275 ? 16.971 -24.546 -14.627 1    19.89  ? 274  TRP A CZ2 1 
ATOM   2156 C  CZ3 . TRP A 1 275 ? 15.804 -25.678 -12.824 1    21.09  ? 274  TRP A CZ3 1 
ATOM   2157 C  CH2 . TRP A 1 275 ? 15.808 -24.821 -13.931 1    20.7   ? 274  TRP A CH2 1 
ATOM   2158 N  N   . ARG A 1 276 ? 21.759 -27.254 -8.437  1    19.5   ? 275  ARG A N   1 
ATOM   2159 C  CA  . ARG A 1 276 ? 22.356 -28.193 -7.488  1    19.31  ? 275  ARG A CA  1 
ATOM   2160 C  C   . ARG A 1 276 ? 21.332 -28.934 -6.594  1    20.16  ? 275  ARG A C   1 
ATOM   2161 O  O   . ARG A 1 276 ? 21.571 -30.094 -6.265  1    21.02  ? 275  ARG A O   1 
ATOM   2162 C  CB  . ARG A 1 276 ? 23.434 -27.508 -6.623  1    20.46  ? 275  ARG A CB  1 
ATOM   2163 C  CG  . ARG A 1 276 ? 22.864 -26.349 -5.781  1    20.76  ? 275  ARG A CG  1 
ATOM   2164 C  CD  . ARG A 1 276 ? 24.024 -25.494 -5.289  1    23.05  ? 275  ARG A CD  1 
ATOM   2165 N  NE  . ARG A 1 276 ? 23.582 -24.316 -4.521  1    25.14  ? 275  ARG A NE  1 
ATOM   2166 C  CZ  . ARG A 1 276 ? 23.322 -23.133 -5.073  1    28.67  ? 275  ARG A CZ  1 
ATOM   2167 N  NH1 . ARG A 1 276 ? 23.416 -22.969 -6.401  1    26.72  ? 275  ARG A NH1 1 
ATOM   2168 N  NH2 . ARG A 1 276 ? 22.939 -22.106 -4.31   1    28.95  ? 275  ARG A NH2 1 
ATOM   2169 N  N   . TYR A 1 277 ? 20.208 -28.291 -6.218  1    19.89  ? 276  TYR A N   1 
ATOM   2170 C  CA  . TYR A 1 277 ? 19.202 -28.992 -5.4    1    21.6   ? 276  TYR A CA  1 
ATOM   2171 C  C   . TYR A 1 277 ? 18.236 -29.837 -6.223  1    23.22  ? 276  TYR A C   1 
ATOM   2172 O  O   . TYR A 1 277 ? 17.525 -30.676 -5.655  1    24.51  ? 276  TYR A O   1 
ATOM   2173 C  CB  . TYR A 1 277 ? 18.377 -28.003 -4.575  1    22.06  ? 276  TYR A CB  1 
ATOM   2174 C  CG  . TYR A 1 277 ? 19.202 -27.283 -3.549  1    23.8   ? 276  TYR A CG  1 
ATOM   2175 C  CD1 . TYR A 1 277 ? 19.665 -27.941 -2.416  1    26.07  ? 276  TYR A CD1 1 
ATOM   2176 C  CD2 . TYR A 1 277 ? 19.464 -25.926 -3.671  1    25.22  ? 276  TYR A CD2 1 
ATOM   2177 C  CE1 . TYR A 1 277 ? 20.402 -27.271 -1.446  1    27.71  ? 276  TYR A CE1 1 
ATOM   2178 C  CE2 . TYR A 1 277 ? 20.188 -25.243 -2.705  1    27.03  ? 276  TYR A CE2 1 
ATOM   2179 C  CZ  . TYR A 1 277 ? 20.626 -25.914 -1.576  1    29.98  ? 276  TYR A CZ  1 
ATOM   2180 O  OH  . TYR A 1 277 ? 21.372 -25.242 -0.644  1    33.7   ? 276  TYR A OH  1 
ATOM   2181 N  N   . GLN A 1 278 ? 18.114 -29.561 -7.528  1    21.04  ? 277  GLN A N   1 
ATOM   2182 C  CA  . GLN A 1 278 ? 17.183 -30.267 -8.404  1    19.71  ? 277  GLN A CA  1 
ATOM   2183 C  C   . GLN A 1 278 ? 17.813 -31.512 -9.006  1    20.27  ? 277  GLN A C   1 
ATOM   2184 O  O   . GLN A 1 278 ? 17.112 -32.47  -9.222  1    21.51  ? 277  GLN A O   1 
ATOM   2185 C  CB  . GLN A 1 278 ? 16.661 -29.36  -9.549  1    20.12  ? 277  GLN A CB  1 
ATOM   2186 C  CG  . GLN A 1 278 ? 15.565 -28.413 -9.079  1    20.04  ? 277  GLN A CG  1 
ATOM   2187 C  CD  . GLN A 1 278 ? 16.159 -27.311 -8.228  1    22.39  ? 277  GLN A CD  1 
ATOM   2188 O  OE1 . GLN A 1 278 ? 17.145 -26.671 -8.653  1    22.92  ? 277  GLN A OE1 1 
ATOM   2189 N  NE2 . GLN A 1 278 ? 15.575 -27.056 -7.04   1    22.18  ? 277  GLN A NE2 1 
ATOM   2190 N  N   . ILE A 1 279 ? 19.096 -31.451 -9.384  1    19.86  ? 278  ILE A N   1 
ATOM   2191 C  CA  . ILE A 1 279 ? 19.774 -32.576 -10.049 1    20.57  ? 278  ILE A CA  1 
ATOM   2192 C  C   . ILE A 1 279 ? 19.662 -33.915 -9.283  1    20.44  ? 278  ILE A C   1 
ATOM   2193 O  O   . ILE A 1 279 ? 19.168 -34.905 -9.864  1    20.44  ? 278  ILE A O   1 
ATOM   2194 C  CB  . ILE A 1 279 ? 21.239 -32.2   -10.382 1    21.2   ? 278  ILE A CB  1 
ATOM   2195 C  CG1 . ILE A 1 279 ? 21.287 -31.009 -11.349 1    20.99  ? 278  ILE A CG1 1 
ATOM   2196 C  CG2 . ILE A 1 279 ? 22.061 -33.422 -10.885 1    22.61  ? 278  ILE A CG2 1 
ATOM   2197 C  CD1 . ILE A 1 279 ? 22.702 -30.293 -11.416 1    20.16  ? 278  ILE A CD1 1 
ATOM   2198 N  N   . PRO A 1 280 ? 20.022 -34     -7.983  1    20.75  ? 279  PRO A N   1 
ATOM   2199 C  CA  . PRO A 1 280 ? 19.872 -35.293 -7.284  1    21.28  ? 279  PRO A CA  1 
ATOM   2200 C  C   . PRO A 1 280 ? 18.403 -35.727 -7.191  1    22     ? 279  PRO A C   1 
ATOM   2201 O  O   . PRO A 1 280 ? 18.088 -36.911 -7.374  1    22.07  ? 279  PRO A O   1 
ATOM   2202 C  CB  . PRO A 1 280 ? 20.498 -35.034 -5.902  1    21.88  ? 279  PRO A CB  1 
ATOM   2203 C  CG  . PRO A 1 280 ? 21.354 -33.803 -6.064  1    22.19  ? 279  PRO A CG  1 
ATOM   2204 C  CD  . PRO A 1 280 ? 20.641 -32.975 -7.117  1    20.62  ? 279  PRO A CD  1 
ATOM   2205 N  N   . ALA A 1 281 ? 17.507 -34.77  -6.891  1    21.92  ? 280  ALA A N   1 
ATOM   2206 C  CA  . ALA A 1 281 ? 16.083 -35.107 -6.735  1    22.7   ? 280  ALA A CA  1 
ATOM   2207 C  C   . ALA A 1 281 ? 15.459 -35.659 -8.015  1    22.18  ? 280  ALA A C   1 
ATOM   2208 O  O   . ALA A 1 281 ? 14.748 -36.655 -7.971  1    22.08  ? 280  ALA A O   1 
ATOM   2209 C  CB  . ALA A 1 281 ? 15.306 -33.891 -6.257  1    23.23  ? 280  ALA A CB  1 
ATOM   2210 N  N   . LEU A 1 282 ? 15.69  -34.995 -9.172  1    21.08  ? 281  LEU A N   1 
ATOM   2211 C  CA  . LEU A 1 282 ? 15.112 -35.452 -10.43  1    21.58  ? 281  LEU A CA  1 
ATOM   2212 C  C   . LEU A 1 282 ? 15.732 -36.796 -10.837 1    21.28  ? 281  LEU A C   1 
ATOM   2213 O  O   . LEU A 1 282 ? 15.022 -37.646 -11.36  1    22.11  ? 281  LEU A O   1 
ATOM   2214 C  CB  . LEU A 1 282 ? 15.309 -34.361 -11.5   1    23.38  ? 281  LEU A CB  1 
ATOM   2215 C  CG  . LEU A 1 282 ? 14.202 -33.299 -11.636 1    27.9   ? 281  LEU A CG  1 
ATOM   2216 C  CD1 . LEU A 1 282 ? 13.794 -32.695 -10.315 1    30.6   ? 281  LEU A CD1 1 
ATOM   2217 C  CD2 . LEU A 1 282 ? 14.646 -32.179 -12.595 1    29.25  ? 281  LEU A CD2 1 
ATOM   2218 N  N   . ALA A 1 283 ? 17.041 -37.004 -10.579 1    21.25  ? 282  ALA A N   1 
ATOM   2219 C  CA  . ALA A 1 283 ? 17.679 -38.289 -10.932 1    22.16  ? 282  ALA A CA  1 
ATOM   2220 C  C   . ALA A 1 283 ? 17.029 -39.405 -10.078 1    23.27  ? 282  ALA A C   1 
ATOM   2221 O  O   . ALA A 1 283 ? 16.606 -40.44  -10.606 1    23.8   ? 282  ALA A O   1 
ATOM   2222 C  CB  . ALA A 1 283 ? 19.172 -38.226 -10.669 1    22.23  ? 282  ALA A CB  1 
ATOM   2223 N  N   . GLN A 1 284 ? 16.856 -39.137 -8.776  1    23.34  ? 283  GLN A N   1 
ATOM   2224 C  CA  . GLN A 1 284 ? 16.253 -40.121 -7.871  1    24.03  ? 283  GLN A CA  1 
ATOM   2225 C  C   . GLN A 1 284 ? 14.811 -40.431 -8.271  1    24.68  ? 283  GLN A C   1 
ATOM   2226 O  O   . GLN A 1 284 ? 14.339 -41.556 -8.084  1    26.03  ? 283  GLN A O   1 
ATOM   2227 C  CB  . GLN A 1 284 ? 16.292 -39.596 -6.412  1    25.79  ? 283  GLN A CB  1 
ATOM   2228 C  CG  . GLN A 1 284 ? 15.83  -40.646 -5.38   1    30.12  ? 283  GLN A CG  1 
ATOM   2229 C  CD  . GLN A 1 284 ? 16.596 -41.954 -5.481  1    37.41  ? 283  GLN A CD  1 
ATOM   2230 O  OE1 . GLN A 1 284 ? 17.808 -41.978 -5.638  1    39.54  ? 283  GLN A OE1 1 
ATOM   2231 N  NE2 . GLN A 1 284 ? 15.896 -43.076 -5.398  1    40.89  ? 283  GLN A NE2 1 
ATOM   2232 N  N   . ALA A 1 285 ? 14.098 -39.424 -8.8    1    23.94  ? 284  ALA A N   1 
ATOM   2233 C  CA  . ALA A 1 285 ? 12.719 -39.584 -9.269  1    24.85  ? 284  ALA A CA  1 
ATOM   2234 C  C   . ALA A 1 285 ? 12.575 -40.391 -10.563 1    25.39  ? 284  ALA A C   1 
ATOM   2235 O  O   . ALA A 1 285 ? 11.459 -40.645 -10.971 1    26.42  ? 284  ALA A O   1 
ATOM   2236 C  CB  . ALA A 1 285 ? 12.038 -38.235 -9.404  1    25.26  ? 284  ALA A CB  1 
ATOM   2237 N  N   . GLY A 1 286 ? 13.686 -40.775 -11.206 1    24.98  ? 285  GLY A N   1 
ATOM   2238 C  CA  . GLY A 1 286 ? 13.691 -41.63  -12.39  1    25.06  ? 285  GLY A CA  1 
ATOM   2239 C  C   . GLY A 1 286 ? 13.951 -40.92  -13.711 1    24.4   ? 285  GLY A C   1 
ATOM   2240 O  O   . GLY A 1 286 ? 13.489 -41.375 -14.771 1    25.14  ? 285  GLY A O   1 
ATOM   2241 N  N   . TYR A 1 287 ? 14.755 -39.836 -13.662 1    22.06  ? 286  TYR A N   1 
ATOM   2242 C  CA  . TYR A 1 287 ? 15.071 -39.064 -14.87  1    21.57  ? 286  TYR A CA  1 
ATOM   2243 C  C   . TYR A 1 287 ? 16.566 -38.977 -15.098 1    20.57  ? 286  TYR A C   1 
ATOM   2244 O  O   . TYR A 1 287 ? 17.335 -39.074 -14.137 1    20.23  ? 286  TYR A O   1 
ATOM   2245 C  CB  . TYR A 1 287 ? 14.488 -37.652 -14.773 1    21.44  ? 286  TYR A CB  1 
ATOM   2246 C  CG  . TYR A 1 287 ? 12.976 -37.722 -14.732 1    21.98  ? 286  TYR A CG  1 
ATOM   2247 C  CD1 . TYR A 1 287 ? 12.242 -37.914 -15.892 1    23.77  ? 286  TYR A CD1 1 
ATOM   2248 C  CD2 . TYR A 1 287 ? 12.297 -37.783 -13.516 1    22.99  ? 286  TYR A CD2 1 
ATOM   2249 C  CE1 . TYR A 1 287 ? 10.859 -38.11  -15.856 1    24.52  ? 286  TYR A CE1 1 
ATOM   2250 C  CE2 . TYR A 1 287 ? 10.913 -37.973 -13.467 1    24.44  ? 286  TYR A CE2 1 
ATOM   2251 C  CZ  . TYR A 1 287 ? 10.209 -38.164 -14.638 1    25.63  ? 286  TYR A CZ  1 
ATOM   2252 O  OH  . TYR A 1 287 ? 8.846  -38.329 -14.611 1    28.43  ? 286  TYR A OH  1 
ATOM   2253 N  N   . ARG A 1 288 ? 16.965 -38.809 -16.372 1    19.61  ? 287  ARG A N   1 
ATOM   2254 C  CA  . ARG A 1 288 ? 18.362 -38.607 -16.765 1    19.57  ? 287  ARG A CA  1 
ATOM   2255 C  C   . ARG A 1 288 ? 18.514 -37.103 -16.918 1    19.83  ? 287  ARG A C   1 
ATOM   2256 O  O   . ARG A 1 288 ? 17.984 -36.507 -17.863 1    20.97  ? 287  ARG A O   1 
ATOM   2257 C  CB  . ARG A 1 288 ? 18.654 -39.293 -18.091 1    20.36  ? 287  ARG A CB  1 
ATOM   2258 C  CG  . ARG A 1 288 ? 20.026 -39.011 -18.645 1    20.51  ? 287  ARG A CG  1 
ATOM   2259 C  CD  . ARG A 1 288 ? 20.087 -39.601 -20.067 1    21.22  ? 287  ARG A CD  1 
ATOM   2260 N  NE  . ARG A 1 288 ? 21.383 -39.314 -20.671 1    20.34  ? 287  ARG A NE  1 
ATOM   2261 C  CZ  . ARG A 1 288 ? 21.746 -39.701 -21.898 1    23.23  ? 287  ARG A CZ  1 
ATOM   2262 N  NH1 . ARG A 1 288 ? 20.938 -40.469 -22.629 1    20.77  ? 287  ARG A NH1 1 
ATOM   2263 N  NH2 . ARG A 1 288 ? 22.925 -39.346 -22.387 1    23.67  ? 287  ARG A NH2 1 
ATOM   2264 N  N   . VAL A 1 289 ? 19.162 -36.476 -15.965 1    19.08  ? 288  VAL A N   1 
ATOM   2265 C  CA  . VAL A 1 289 ? 19.267 -35.017 -15.92  1    20.61  ? 288  VAL A CA  1 
ATOM   2266 C  C   . VAL A 1 289 ? 20.53  -34.562 -16.634 1    20.94  ? 288  VAL A C   1 
ATOM   2267 O  O   . VAL A 1 289 ? 21.619 -35.069 -16.362 1    21.38  ? 288  VAL A O   1 
ATOM   2268 C  CB  . VAL A 1 289 ? 19.308 -34.553 -14.433 1    21.91  ? 288  VAL A CB  1 
ATOM   2269 C  CG1 . VAL A 1 289 ? 19.524 -33.047 -14.316 1    22.01  ? 288  VAL A CG1 1 
ATOM   2270 C  CG2 . VAL A 1 289 ? 18.045 -34.983 -13.69  1    23.35  ? 288  VAL A CG2 1 
ATOM   2271 N  N   . LEU A 1 290 ? 20.4   -33.557 -17.492 1    20.42  ? 289  LEU A N   1 
ATOM   2272 C  CA  . LEU A 1 290 ? 21.513 -32.936 -18.227 1    20.46  ? 289  LEU A CA  1 
ATOM   2273 C  C   . LEU A 1 290 ? 21.454 -31.443 -17.801 1    19.99  ? 289  LEU A C   1 
ATOM   2274 O  O   . LEU A 1 290 ? 20.601 -30.724 -18.299 1    20.8   ? 289  LEU A O   1 
ATOM   2275 C  CB  . LEU A 1 290 ? 21.257 -33.033 -19.75  1    21.8   ? 289  LEU A CB  1 
ATOM   2276 C  CG  . LEU A 1 290 ? 21.012 -34.468 -20.271 1    27.01  ? 289  LEU A CG  1 
ATOM   2277 C  CD1 . LEU A 1 290 ? 20.438 -34.459 -21.706 1    29.62  ? 289  LEU A CD1 1 
ATOM   2278 C  CD2 . LEU A 1 290 ? 22.247 -35.244 -20.164 1    28.69  ? 289  LEU A CD2 1 
ATOM   2279 N  N   . ALA A 1 291 ? 22.33  -30.991 -16.887 1    18.27  ? 290  ALA A N   1 
ATOM   2280 C  CA  . ALA A 1 291 ? 22.262 -29.603 -16.403 1    18.12  ? 290  ALA A CA  1 
ATOM   2281 C  C   . ALA A 1 291 ? 23.319 -28.838 -17.158 1    18.92  ? 290  ALA A C   1 
ATOM   2282 O  O   . ALA A 1 291 ? 24.498 -29.137 -17.024 1    18.77  ? 290  ALA A O   1 
ATOM   2283 C  CB  . ALA A 1 291 ? 22.501 -29.534 -14.895 1    17.8   ? 290  ALA A CB  1 
ATOM   2284 N  N   . MET A 1 292 ? 22.891 -27.96  -18.038 1    19     ? 291  MET A N   1 
ATOM   2285 C  CA  . MET A 1 292 ? 23.815 -27.26  -18.936 1    19.9   ? 291  MET A CA  1 
ATOM   2286 C  C   . MET A 1 292 ? 24.546 -26.111 -18.281 1    19.48  ? 291  MET A C   1 
ATOM   2287 O  O   . MET A 1 292 ? 24.016 -25.473 -17.371 1    19.66  ? 291  MET A O   1 
ATOM   2288 C  CB  . MET A 1 292 ? 23.002 -26.602 -20.084 1    21.99  ? 291  MET A CB  1 
ATOM   2289 C  CG  . MET A 1 292 ? 22.01  -27.512 -20.739 1    23.6   ? 291  MET A CG  1 
ATOM   2290 S  SD  . MET A 1 292 ? 22.875 -28.822 -21.613 1    24.82  ? 291  MET A SD  1 
ATOM   2291 C  CE  . MET A 1 292 ? 23.991 -27.867 -22.727 1    25.73  ? 291  MET A CE  1 
ATOM   2292 N  N   . ASP A 1 293 ? 25.764 -25.826 -18.792 1    19.48  ? 292  ASP A N   1 
ATOM   2293 C  CA  . ASP A 1 293 ? 26.387 -24.534 -18.702 1    20.06  ? 292  ASP A CA  1 
ATOM   2294 C  C   . ASP A 1 293 ? 25.931 -23.936 -20.065 1    19.75  ? 292  ASP A C   1 
ATOM   2295 O  O   . ASP A 1 293 ? 26.303 -24.447 -21.15  1    19.38  ? 292  ASP A O   1 
ATOM   2296 C  CB  . ASP A 1 293 ? 27.923 -24.576 -18.674 1    20.4   ? 292  ASP A CB  1 
ATOM   2297 C  CG  . ASP A 1 293 ? 28.491 -24.549 -17.251 1    21.86  ? 292  ASP A CG  1 
ATOM   2298 O  OD1 . ASP A 1 293 ? 27.758 -24.097 -16.309 1    22.06  ? 292  ASP A OD1 1 
ATOM   2299 O  OD2 . ASP A 1 293 ? 29.627 -24.989 -17.068 1    21.86  ? 292  ASP A OD2 1 
ATOM   2300 N  N   . MET A 1 294 ? 25.066 -22.93  -20.021 1    19.3   ? 293  MET A N   1 
ATOM   2301 C  CA  . MET A 1 294 ? 24.557 -22.319 -21.254 1    19.59  ? 293  MET A CA  1 
ATOM   2302 C  C   . MET A 1 294 ? 25.718 -21.616 -22.007 1    19.73  ? 293  MET A C   1 
ATOM   2303 O  O   . MET A 1 294 ? 26.774 -21.284 -21.398 1    20.59  ? 293  MET A O   1 
ATOM   2304 C  CB  . MET A 1 294 ? 23.369 -21.377 -20.983 1    21.44  ? 293  MET A CB  1 
ATOM   2305 C  CG  . MET A 1 294 ? 22.223 -22.098 -20.24  1    23.76  ? 293  MET A CG  1 
ATOM   2306 S  SD  . MET A 1 294 ? 21.517 -23.477 -21.206 1    25.3   ? 293  MET A SD  1 
ATOM   2307 C  CE  . MET A 1 294 ? 20.657 -22.615 -22.39  1    23.22  ? 293  MET A CE  1 
ATOM   2308 N  N   . LYS A 1 295 ? 25.542 -21.362 -23.311 1    19.69  ? 294  LYS A N   1 
ATOM   2309 C  CA  . LYS A 1 295 ? 26.599 -20.685 -24.097 1    20.6   ? 294  LYS A CA  1 
ATOM   2310 C  C   . LYS A 1 295 ? 26.998 -19.36  -23.46  1    19.86  ? 294  LYS A C   1 
ATOM   2311 O  O   . LYS A 1 295 ? 26.127 -18.589 -23.051 1    19.95  ? 294  LYS A O   1 
ATOM   2312 C  CB  . LYS A 1 295 ? 26.158 -20.421 -25.519 1    21.93  ? 294  LYS A CB  1 
ATOM   2313 C  CG  . LYS A 1 295 ? 27.301 -20.028 -26.463 1    24.91  ? 294  LYS A CG  1 
ATOM   2314 C  CD  . LYS A 1 295 ? 26.635 -19.589 -27.774 1    28.51  ? 294  LYS A CD  1 
ATOM   2315 C  CE  . LYS A 1 295 ? 27.589 -19.374 -28.891 1    31.08  ? 294  LYS A CE  1 
ATOM   2316 N  NZ  . LYS A 1 295 ? 26.853 -19.294 -30.177 1    29.04  ? 294  LYS A NZ  1 
ATOM   2317 N  N   . GLY A 1 296 ? 28.292 -19.159 -23.32  1    19.58  ? 295  GLY A N   1 
ATOM   2318 C  CA  . GLY A 1 296 ? 28.816 -17.973 -22.655 1    20.71  ? 295  GLY A CA  1 
ATOM   2319 C  C   . GLY A 1 296 ? 29.196 -18.169 -21.196 1    21.94  ? 295  GLY A C   1 
ATOM   2320 O  O   . GLY A 1 296 ? 29.77  -17.262 -20.58  1    22.17  ? 295  GLY A O   1 
ATOM   2321 N  N   . TYR A 1 297 ? 28.892 -19.357 -20.603 1    20.29  ? 296  TYR A N   1 
ATOM   2322 C  CA  . TYR A 1 297 ? 29.097 -19.601 -19.19  1    20.15  ? 296  TYR A CA  1 
ATOM   2323 C  C   . TYR A 1 297 ? 29.962 -20.809 -18.843 1    21.22  ? 296  TYR A C   1 
ATOM   2324 O  O   . TYR A 1 297 ? 29.903 -21.831 -19.534 1    21.14  ? 296  TYR A O   1 
ATOM   2325 C  CB  . TYR A 1 297 ? 27.702 -19.903 -18.581 1    19.22  ? 296  TYR A CB  1 
ATOM   2326 C  CG  . TYR A 1 297 ? 26.754 -18.722 -18.562 1    18.94  ? 296  TYR A CG  1 
ATOM   2327 C  CD1 . TYR A 1 297 ? 25.889 -18.478 -19.627 1    19.3   ? 296  TYR A CD1 1 
ATOM   2328 C  CD2 . TYR A 1 297 ? 26.653 -17.909 -17.437 1    20.22  ? 296  TYR A CD2 1 
ATOM   2329 C  CE1 . TYR A 1 297 ? 24.942 -17.453 -19.566 1    19.7   ? 296  TYR A CE1 1 
ATOM   2330 C  CE2 . TYR A 1 297 ? 25.738 -16.871 -17.375 1    20.04  ? 296  TYR A CE2 1 
ATOM   2331 C  CZ  . TYR A 1 297 ? 24.893 -16.639 -18.439 1    19.87  ? 296  TYR A CZ  1 
ATOM   2332 O  OH  . TYR A 1 297 ? 23.978 -15.627 -18.313 1    22.36  ? 296  TYR A OH  1 
ATOM   2333 N  N   . GLY A 1 298 ? 30.595 -20.74  -17.671 1    21.44  ? 297  GLY A N   1 
ATOM   2334 C  CA  . GLY A 1 298 ? 31.332 -21.835 -17.047 1    21.85  ? 297  GLY A CA  1 
ATOM   2335 C  C   . GLY A 1 298 ? 32.329 -22.488 -17.971 1    22.35  ? 297  GLY A C   1 
ATOM   2336 O  O   . GLY A 1 298 ? 33.195 -21.802 -18.543 1    23.08  ? 297  GLY A O   1 
ATOM   2337 N  N   . GLU A 1 299 ? 32.165 -23.807 -18.181 1    21.64  ? 298  GLU A N   1 
ATOM   2338 C  CA  . GLU A 1 299 ? 33.046 -24.549 -19.081 1    21.55  ? 298  GLU A CA  1 
ATOM   2339 C  C   . GLU A 1 299 ? 32.574 -24.596 -20.524 1    22.87  ? 298  GLU A C   1 
ATOM   2340 O  O   . GLU A 1 299 ? 33.261 -25.202 -21.369 1    23.79  ? 298  GLU A O   1 
ATOM   2341 C  CB  . GLU A 1 299 ? 33.299 -25.948 -18.548 1    22.4   ? 298  GLU A CB  1 
ATOM   2342 C  CG  . GLU A 1 299 ? 33.962 -25.921 -17.178 1    26.35  ? 298  GLU A CG  1 
ATOM   2343 C  CD  . GLU A 1 299 ? 34.241 -27.325 -16.691 1    36     ? 298  GLU A CD  1 
ATOM   2344 O  OE1 . GLU A 1 299 ? 33.76  -27.685 -15.591 1    40.44  ? 298  GLU A OE1 1 
ATOM   2345 O  OE2 . GLU A 1 299 ? 34.884 -28.088 -17.45  1    34.42  ? 298  GLU A OE2 1 
ATOM   2346 N  N   . SER A 1 300 ? 31.426 -23.944 -20.848 1    21.48  ? 299  SER A N   1 
ATOM   2347 C  CA  . SER A 1 300 ? 30.998 -23.866 -22.241 1    21.57  ? 299  SER A CA  1 
ATOM   2348 C  C   . SER A 1 300 ? 31.756 -22.715 -22.919 1    22.91  ? 299  SER A C   1 
ATOM   2349 O  O   . SER A 1 300 ? 32.253 -21.796 -22.245 1    23.62  ? 299  SER A O   1 
ATOM   2350 C  CB  . SER A 1 300 ? 29.495 -23.65  -22.375 1    21.55  ? 299  SER A CB  1 
ATOM   2351 O  OG  . SER A 1 300 ? 28.794 -24.776 -21.861 1    20.49  ? 299  SER A OG  1 
ATOM   2352 N  N   . SER A 1 301 ? 31.838 -22.764 -24.241 1    23.92  ? 300  SER A N   1 
ATOM   2353 C  CA  . SER A 1 301 ? 32.518 -21.724 -25.017 1    24.02  ? 300  SER A CA  1 
ATOM   2354 C  C   . SER A 1 301 ? 31.806 -20.388 -24.844 1    24.15  ? 300  SER A C   1 
ATOM   2355 O  O   . SER A 1 301 ? 30.583 -20.347 -24.628 1    23.4   ? 300  SER A O   1 
ATOM   2356 C  CB  . SER A 1 301 ? 32.533 -22.119 -26.485 1    24.83  ? 300  SER A CB  1 
ATOM   2357 O  OG  . SER A 1 301 ? 33.271 -23.329 -26.602 1    26.63  ? 300  SER A OG  1 
ATOM   2358 N  N   . ALA A 1 302 ? 32.568 -19.294 -24.96  1    24.19  ? 301  ALA A N   1 
ATOM   2359 C  CA  . ALA A 1 302 ? 32.01  -17.965 -24.815 1    24.64  ? 301  ALA A CA  1 
ATOM   2360 C  C   . ALA A 1 302 ? 32.592 -17.07  -25.933 1    25.66  ? 301  ALA A C   1 
ATOM   2361 O  O   . ALA A 1 302 ? 33.474 -16.254 -25.656 1    25.82  ? 301  ALA A O   1 
ATOM   2362 C  CB  . ALA A 1 302 ? 32.361 -17.391 -23.444 1    25.29  ? 301  ALA A CB  1 
ATOM   2363 N  N   . PRO A 1 303 ? 32.105 -17.225 -27.176 1    26.33  ? 302  PRO A N   1 
ATOM   2364 C  CA  . PRO A 1 303 ? 32.594 -16.355 -28.26  1    27.46  ? 302  PRO A CA  1 
ATOM   2365 C  C   . PRO A 1 303 ? 32.174 -14.921 -27.989 1    28.19  ? 302  PRO A C   1 
ATOM   2366 O  O   . PRO A 1 303 ? 31.186 -14.661 -27.281 1    27.14  ? 302  PRO A O   1 
ATOM   2367 C  CB  . PRO A 1 303 ? 31.941 -16.93  -29.526 1    28.22  ? 302  PRO A CB  1 
ATOM   2368 C  CG  . PRO A 1 303 ? 30.716 -17.675 -29.027 1    28.88  ? 302  PRO A CG  1 
ATOM   2369 C  CD  . PRO A 1 303 ? 31.07  -18.173 -27.653 1    26.61  ? 302  PRO A CD  1 
ATOM   2370 N  N   . PRO A 1 304 ? 32.974 -13.952 -28.45  1    28.86  ? 303  PRO A N   1 
ATOM   2371 C  CA  . PRO A 1 304 ? 32.676 -12.553 -28.097 1    28.5   ? 303  PRO A CA  1 
ATOM   2372 C  C   . PRO A 1 304 ? 31.545 -11.873 -28.878 1    27.71  ? 303  PRO A C   1 
ATOM   2373 O  O   . PRO A 1 304 ? 30.999 -10.879 -28.386 1    28.28  ? 303  PRO A O   1 
ATOM   2374 C  CB  . PRO A 1 304 ? 34.023 -11.85  -28.35  1    29.55  ? 303  PRO A CB  1 
ATOM   2375 C  CG  . PRO A 1 304 ? 34.641 -12.655 -29.45  1    30.72  ? 303  PRO A CG  1 
ATOM   2376 C  CD  . PRO A 1 304 ? 34.229 -14.081 -29.224 1    29.05  ? 303  PRO A CD  1 
ATOM   2377 N  N   . GLU A 1 305 ? 31.225 -12.356 -30.094 1    27.12  ? 304  GLU A N   1 
ATOM   2378 C  CA  . GLU A 1 305 ? 30.249 -11.679 -30.974 1    27.42  ? 304  GLU A CA  1 
ATOM   2379 C  C   . GLU A 1 305 ? 28.847 -11.657 -30.391 1    26.67  ? 304  GLU A C   1 
ATOM   2380 O  O   . GLU A 1 305 ? 28.393 -12.694 -29.906 1    26.46  ? 304  GLU A O   1 
ATOM   2381 C  CB  . GLU A 1 305 ? 30.218 -12.325 -32.363 1    31.39  ? 304  GLU A CB  1 
ATOM   2382 C  CG  . GLU A 1 305 ? 31.554 -12.264 -33.088 1    37.13  ? 304  GLU A CG  1 
ATOM   2383 C  CD  . GLU A 1 305 ? 32.531 -13.392 -32.789 1    45.3   ? 304  GLU A CD  1 
ATOM   2384 O  OE1 . GLU A 1 305 ? 32.172 -14.334 -32.039 1    39.74  ? 304  GLU A OE1 1 
ATOM   2385 O  OE2 . GLU A 1 305 ? 33.669 -13.327 -33.317 1    50.07  ? 304  GLU A OE2 1 
ATOM   2386 N  N   . ILE A 1 306 ? 28.18  -10.506 -30.424 1    25.84  ? 305  ILE A N   1 
ATOM   2387 C  CA  . ILE A 1 306 ? 26.813 -10.373 -29.885 1    26.55  ? 305  ILE A CA  1 
ATOM   2388 C  C   . ILE A 1 306 ? 25.84  -11.344 -30.553 1    27.15  ? 305  ILE A C   1 
ATOM   2389 O  O   . ILE A 1 306 ? 25.053 -11.98  -29.855 1    27.16  ? 305  ILE A O   1 
ATOM   2390 C  CB  . ILE A 1 306 ? 26.332 -8.899  -30.018 1    26.05  ? 305  ILE A CB  1 
ATOM   2391 C  CG1 . ILE A 1 306 ? 27.074 -7.986  -29.016 1    26.83  ? 305  ILE A CG1 1 
ATOM   2392 C  CG2 . ILE A 1 306 ? 24.811 -8.767  -29.857 1    25.73  ? 305  ILE A CG2 1 
ATOM   2393 C  CD1 . ILE A 1 306 ? 26.839 -6.451  -29.361 1    28.41  ? 305  ILE A CD1 1 
ATOM   2394 N  N   . GLU A 1 307 ? 25.876 -11.44  -31.897 1    27.33  ? 306  GLU A N   1 
ATOM   2395 C  CA  . GLU A 1 307 ? 24.93  -12.237 -32.679 1    27.87  ? 306  GLU A CA  1 
ATOM   2396 C  C   . GLU A 1 307 ? 25.034 -13.77  -32.438 1    27.07  ? 306  GLU A C   1 
ATOM   2397 O  O   . GLU A 1 307 ? 24.086 -14.507 -32.736 1    28.14  ? 306  GLU A O   1 
ATOM   2398 C  CB  . GLU A 1 307 ? 25.034 -11.893 -34.175 1    31.83  ? 306  GLU A CB  1 
ATOM   2399 C  CG  . GLU A 1 307 ? 26.42  -12.167 -34.761 1    39.75  ? 306  GLU A CG  1 
ATOM   2400 C  CD  . GLU A 1 307 ? 27.511 -11.105 -34.649 1    49.42  ? 306  GLU A CD  1 
ATOM   2401 O  OE1 . GLU A 1 307 ? 27.366 -10.153 -33.844 1    48.31  ? 306  GLU A OE1 1 
ATOM   2402 O  OE2 . GLU A 1 307 ? 28.527 -11.24  -35.375 1    53.82  ? 306  GLU A OE2 1 
ATOM   2403 N  N   . GLU A 1 308 ? 26.124 -14.226 -31.812 1    25.91  ? 307  GLU A N   1 
ATOM   2404 C  CA  . GLU A 1 308 ? 26.246 -15.635 -31.415 1    25     ? 307  GLU A CA  1 
ATOM   2405 C  C   . GLU A 1 308 ? 25.242 -15.994 -30.279 1    24.33  ? 307  GLU A C   1 
ATOM   2406 O  O   . GLU A 1 308 ? 25.144 -17.168 -29.912 1    24.75  ? 307  GLU A O   1 
ATOM   2407 C  CB  . GLU A 1 308 ? 27.661 -15.882 -30.863 1    25.98  ? 307  GLU A CB  1 
ATOM   2408 C  CG  . GLU A 1 308 ? 28.68  -16.063 -31.964 1    30     ? 307  GLU A CG  1 
ATOM   2409 C  CD  . GLU A 1 308 ? 28.378 -17.356 -32.696 1    36.98  ? 307  GLU A CD  1 
ATOM   2410 O  OE1 . GLU A 1 308 ? 28.588 -18.439 -32.103 1    34.92  ? 307  GLU A OE1 1 
ATOM   2411 O  OE2 . GLU A 1 308 ? 27.836 -17.284 -33.822 1    42.55  ? 307  GLU A OE2 1 
ATOM   2412 N  N   . TYR A 1 309 ? 24.632 -14.987 -29.649 1    23.27  ? 308  TYR A N   1 
ATOM   2413 C  CA  . TYR A 1 309 ? 23.738 -15.19  -28.507 1    23.34  ? 308  TYR A CA  1 
ATOM   2414 C  C   . TYR A 1 309 ? 22.295 -14.829 -28.784 1    23.04  ? 308  TYR A C   1 
ATOM   2415 O  O   . TYR A 1 309 ? 21.512 -14.672 -27.838 1    21.91  ? 308  TYR A O   1 
ATOM   2416 C  CB  . TYR A 1 309 ? 24.268 -14.446 -27.282 1    23.19  ? 308  TYR A CB  1 
ATOM   2417 C  CG  . TYR A 1 309 ? 25.666 -14.885 -26.907 1    22.64  ? 308  TYR A CG  1 
ATOM   2418 C  CD1 . TYR A 1 309 ? 26.784 -14.318 -27.517 1    22.8   ? 308  TYR A CD1 1 
ATOM   2419 C  CD2 . TYR A 1 309 ? 25.873 -15.868 -25.947 1    23.01  ? 308  TYR A CD2 1 
ATOM   2420 C  CE1 . TYR A 1 309 ? 28.072 -14.695 -27.149 1    23.02  ? 308  TYR A CE1 1 
ATOM   2421 C  CE2 . TYR A 1 309 ? 27.155 -16.29  -25.607 1    23.62  ? 308  TYR A CE2 1 
ATOM   2422 C  CZ  . TYR A 1 309 ? 28.251 -15.707 -26.219 1    24.26  ? 308  TYR A CZ  1 
ATOM   2423 O  OH  . TYR A 1 309 ? 29.513 -16.072 -25.804 1    24.05  ? 308  TYR A OH  1 
ATOM   2424 N  N   . CYS A 1 310 ? 21.924 -14.732 -30.074 1    23.55  ? 309  CYS A N   1 
ATOM   2425 C  CA  . CYS A 1 310 ? 20.525 -14.482 -30.388 1    23.98  ? 309  CYS A CA  1 
ATOM   2426 C  C   . CYS A 1 310 ? 19.785 -15.824 -30.198 1    23.74  ? 309  CYS A C   1 
ATOM   2427 O  O   . CYS A 1 310 ? 20.402 -16.895 -30.235 1    23.23  ? 309  CYS A O   1 
ATOM   2428 C  CB  . CYS A 1 310 ? 20.358 -13.905 -31.785 1    25.53  ? 309  CYS A CB  1 
ATOM   2429 S  SG  . CYS A 1 310 ? 20.668 -15.088 -33.109 1    28.17  ? 309  CYS A SG  1 
ATOM   2430 N  N   . MET A 1 311 ? 18.479 -15.766 -29.955 1    24.15  ? 310  MET A N   1 
ATOM   2431 C  CA  . MET A 1 311 ? 17.712 -16.977 -29.66  1    24.69  ? 310  MET A CA  1 
ATOM   2432 C  C   . MET A 1 311 ? 17.729 -18.006 -30.77  1    23.71  ? 310  MET A C   1 
ATOM   2433 O  O   . MET A 1 311 ? 17.815 -19.203 -30.486 1    23.81  ? 310  MET A O   1 
ATOM   2434 C  CB  . MET A 1 311 ? 16.279 -16.639 -29.258 1    27.25  ? 310  MET A CB  1 
ATOM   2435 C  CG  . MET A 1 311 ? 15.653 -17.749 -28.456 1    34.38  ? 310  MET A CG  1 
ATOM   2436 S  SD  . MET A 1 311 ? 16.484 -17.873 -26.836 1    40.85  ? 310  MET A SD  1 
ATOM   2437 C  CE  . MET A 1 311 ? 15.843 -16.648 -26.125 1    35.24  ? 310  MET A CE  1 
ATOM   2438 N  N   . GLU A 1 312 ? 17.688 -17.561 -32.033 1    22.66  ? 311  GLU A N   1 
ATOM   2439 C  CA  . GLU A 1 312 ? 17.735 -18.485 -33.165 1    23.55  ? 311  GLU A CA  1 
ATOM   2440 C  C   . GLU A 1 312 ? 19.021 -19.34  -33.141 1    23.77  ? 311  GLU A C   1 
ATOM   2441 O  O   . GLU A 1 312 ? 18.956 -20.578 -33.261 1    24.48  ? 311  GLU A O   1 
ATOM   2442 C  CB  . GLU A 1 312 ? 17.663 -17.69  -34.465 1    25.04  ? 311  GLU A CB  1 
ATOM   2443 C  CG  . GLU A 1 312 ? 17.532 -18.627 -35.64  1    28.19  ? 311  GLU A CG  1 
ATOM   2444 C  CD  . GLU A 1 312 ? 17.35  -17.936 -36.976 1    32.75  ? 311  GLU A CD  1 
ATOM   2445 O  OE1 . GLU A 1 312 ? 17.075 -18.656 -37.962 1    34.43  ? 311  GLU A OE1 1 
ATOM   2446 O  OE2 . GLU A 1 312 ? 17.481 -16.692 -37.042 1    30.76  ? 311  GLU A OE2 1 
ATOM   2447 N  N   . VAL A 1 313 ? 20.175 -18.685 -32.92  1    21.99  ? 312  VAL A N   1 
ATOM   2448 C  CA  . VAL A 1 313 ? 21.441 -19.382 -32.838 1    22.23  ? 312  VAL A CA  1 
ATOM   2449 C  C   . VAL A 1 313 ? 21.49  -20.303 -31.646 1    21.79  ? 312  VAL A C   1 
ATOM   2450 O  O   . VAL A 1 313 ? 21.865 -21.476 -31.796 1    21.26  ? 312  VAL A O   1 
ATOM   2451 C  CB  . VAL A 1 313 ? 22.6   -18.367 -32.873 1    23.22  ? 312  VAL A CB  1 
ATOM   2452 C  CG1 . VAL A 1 313 ? 23.942 -19.017 -32.478 1    23.61  ? 312  VAL A CG1 1 
ATOM   2453 C  CG2 . VAL A 1 313 ? 22.688 -17.754 -34.27  1    24.62  ? 312  VAL A CG2 1 
ATOM   2454 N  N   . LEU A 1 314 ? 21.084 -19.795 -30.482 1    21.08  ? 313  LEU A N   1 
ATOM   2455 C  CA  . LEU A 1 314 ? 21.129 -20.578 -29.243 1    21.79  ? 313  LEU A CA  1 
ATOM   2456 C  C   . LEU A 1 314 ? 20.233 -21.835 -29.346 1    21.54  ? 313  LEU A C   1 
ATOM   2457 O  O   . LEU A 1 314 ? 20.648 -22.918 -28.931 1    21.05  ? 313  LEU A O   1 
ATOM   2458 C  CB  . LEU A 1 314 ? 20.725 -19.742 -28.025 1    21.08  ? 313  LEU A CB  1 
ATOM   2459 C  CG  . LEU A 1 314 ? 21.696 -18.573 -27.707 1    22.34  ? 313  LEU A CG  1 
ATOM   2460 C  CD1 . LEU A 1 314 ? 21.034 -17.607 -26.723 1    23.55  ? 313  LEU A CD1 1 
ATOM   2461 C  CD2 . LEU A 1 314 ? 23.016 -19.115 -27.166 1    23.51  ? 313  LEU A CD2 1 
ATOM   2462 N  N   . CYS A 1 315 ? 19.04  -21.691 -29.93  1    21.56  ? 314  CYS A N   1 
ATOM   2463 C  CA  . CYS A 1 315 ? 18.129 -22.823 -30.097 1    22.08  ? 314  CYS A CA  1 
ATOM   2464 C  C   . CYS A 1 315 ? 18.673 -23.848 -31.082 1    22.76  ? 314  CYS A C   1 
ATOM   2465 O  O   . CYS A 1 315 ? 18.603 -25.046 -30.801 1    22.63  ? 314  CYS A O   1 
ATOM   2466 C  CB  . CYS A 1 315 ? 16.742 -22.339 -30.505 1    22.83  ? 314  CYS A CB  1 
ATOM   2467 S  SG  . CYS A 1 315 ? 15.822 -21.57  -29.158 1    24.49  ? 314  CYS A SG  1 
ATOM   2468 N  N   . LYS A 1 316 ? 19.246 -23.392 -32.205 1    22.43  ? 315  LYS A N   1 
ATOM   2469 C  CA  . LYS A 1 316 ? 19.844 -24.3   -33.219 1    22.22  ? 315  LYS A CA  1 
ATOM   2470 C  C   . LYS A 1 316 ? 20.961 -25.11  -32.577 1    22.42  ? 315  LYS A C   1 
ATOM   2471 O  O   . LYS A 1 316 ? 21.086 -26.316 -32.816 1    22.61  ? 315  LYS A O   1 
ATOM   2472 C  CB  . LYS A 1 316 ? 20.382 -23.508 -34.427 1    24.86  ? 315  LYS A CB  1 
ATOM   2473 C  CG  . LYS A 1 316 ? 19.278 -23.156 -35.418 1    31.45  ? 315  LYS A CG  1 
ATOM   2474 C  CD  . LYS A 1 316 ? 19.774 -22.296 -36.595 1    37.22  ? 315  LYS A CD  1 
ATOM   2475 C  CE  . LYS A 1 316 ? 18.594 -21.868 -37.443 1    41.51  ? 315  LYS A CE  1 
ATOM   2476 N  NZ  . LYS A 1 316 ? 18.977 -20.878 -38.485 1    44.58  ? 315  LYS A NZ  1 
ATOM   2477 N  N   . GLU A 1 317 ? 21.761 -24.454 -31.73  1    21.18  ? 316  GLU A N   1 
ATOM   2478 C  CA  . GLU A 1 317 ? 22.83  -25.148 -31.013 1    21.57  ? 316  GLU A CA  1 
ATOM   2479 C  C   . GLU A 1 317 ? 22.27  -26.197 -30.03  1    20.61  ? 316  GLU A C   1 
ATOM   2480 O  O   . GLU A 1 317 ? 22.875 -27.255 -29.903 1    21.37  ? 316  GLU A O   1 
ATOM   2481 C  CB  . GLU A 1 317 ? 23.705 -24.167 -30.264 1    23.27  ? 316  GLU A CB  1 
ATOM   2482 C  CG  . GLU A 1 317 ? 24.65  -23.408 -31.18  1    28.35  ? 316  GLU A CG  1 
ATOM   2483 C  CD  . GLU A 1 317 ? 25.364 -22.257 -30.487 1    34.71  ? 316  GLU A CD  1 
ATOM   2484 O  OE1 . GLU A 1 317 ? 25.096 -22.002 -29.288 1    34.91  ? 316  GLU A OE1 1 
ATOM   2485 O  OE2 . GLU A 1 317 ? 26.19  -21.6   -31.158 1    37.07  ? 316  GLU A OE2 1 
ATOM   2486 N  N   . MET A 1 318 ? 21.157 -25.919 -29.337 1    20.59  ? 317  MET A N   1 
ATOM   2487 C  CA  . MET A 1 318 ? 20.583 -26.895 -28.414 1    20.9   ? 317  MET A CA  1 
ATOM   2488 C  C   . MET A 1 318 ? 20.025 -28.1   -29.24  1    21.35  ? 317  MET A C   1 
ATOM   2489 O  O   . MET A 1 318 ? 20.085 -29.22  -28.781 1    20.71  ? 317  MET A O   1 
ATOM   2490 C  CB  . MET A 1 318 ? 19.537 -26.268 -27.501 1    22.11  ? 317  MET A CB  1 
ATOM   2491 C  CG  . MET A 1 318 ? 20.12  -25.272 -26.518 1    23.55  ? 317  MET A CG  1 
ATOM   2492 S  SD  . MET A 1 318 ? 21.422 -25.964 -25.432 1    27.16  ? 317  MET A SD  1 
ATOM   2493 C  CE  . MET A 1 318 ? 20.467 -27.15  -24.536 1    27.42  ? 317  MET A CE  1 
ATOM   2494 N  N   . VAL A 1 319 ? 19.532 -27.848 -30.476 1    21.2   ? 318  VAL A N   1 
ATOM   2495 C  CA  . VAL A 1 319 ? 19.105 -28.959 -31.341 1    21.69  ? 318  VAL A CA  1 
ATOM   2496 C  C   . VAL A 1 319 ? 20.333 -29.8   -31.72  1    20.98  ? 318  VAL A C   1 
ATOM   2497 O  O   . VAL A 1 319 ? 20.305 -31.026 -31.627 1    22.24  ? 318  VAL A O   1 
ATOM   2498 C  CB  . VAL A 1 319 ? 18.365 -28.406 -32.57  1    23.66  ? 318  VAL A CB  1 
ATOM   2499 C  CG1 . VAL A 1 319 ? 18.146 -29.524 -33.587 1    24.61  ? 318  VAL A CG1 1 
ATOM   2500 C  CG2 . VAL A 1 319 ? 17.029 -27.812 -32.127 1    25.08  ? 318  VAL A CG2 1 
ATOM   2501 N  N   . THR A 1 320 ? 21.427 -29.152 -32.105 1    21.23  ? 319  THR A N   1 
ATOM   2502 C  CA  . THR A 1 320 ? 22.664 -29.85  -32.449 1    21.88  ? 319  THR A CA  1 
ATOM   2503 C  C   . THR A 1 320 ? 23.182 -30.672 -31.263 1    21.41  ? 319  THR A C   1 
ATOM   2504 O  O   . THR A 1 320 ? 23.615 -31.819 -31.425 1    21.49  ? 319  THR A O   1 
ATOM   2505 C  CB  . THR A 1 320 ? 23.712 -28.892 -32.978 1    24.8   ? 319  THR A CB  1 
ATOM   2506 O  OG1 . THR A 1 320 ? 23.17  -28.215 -34.129 1    25.48  ? 319  THR A OG1 1 
ATOM   2507 C  CG2 . THR A 1 320 ? 25.014 -29.62  -33.372 1    26.77  ? 319  THR A CG2 1 
ATOM   2508 N  N   . PHE A 1 321 ? 23.074 -30.1   -30.058 1    20.93  ? 320  PHE A N   1 
ATOM   2509 C  CA  . PHE A 1 321 ? 23.482 -30.771 -28.806 1    20.18  ? 320  PHE A CA  1 
ATOM   2510 C  C   . PHE A 1 321 ? 22.723 -32.117 -28.65  1    20.03  ? 320  PHE A C   1 
ATOM   2511 O  O   . PHE A 1 321 ? 23.347 -33.161 -28.512 1    20.22  ? 320  PHE A O   1 
ATOM   2512 C  CB  . PHE A 1 321 ? 23.166 -29.816 -27.634 1    20.05  ? 320  PHE A CB  1 
ATOM   2513 C  CG  . PHE A 1 321 ? 23.463 -30.42  -26.288 1    20.24  ? 320  PHE A CG  1 
ATOM   2514 C  CD1 . PHE A 1 321 ? 24.772 -30.53  -25.83  1    22.27  ? 320  PHE A CD1 1 
ATOM   2515 C  CD2 . PHE A 1 321 ? 22.431 -30.825 -25.449 1    21.85  ? 320  PHE A CD2 1 
ATOM   2516 C  CE1 . PHE A 1 321 ? 25.042 -31.074 -24.57  1    22.95  ? 320  PHE A CE1 1 
ATOM   2517 C  CE2 . PHE A 1 321 ? 22.709 -31.373 -24.182 1    22.88  ? 320  PHE A CE2 1 
ATOM   2518 C  CZ  . PHE A 1 321 ? 24.012 -31.483 -23.756 1    23.28  ? 320  PHE A CZ  1 
ATOM   2519 N  N   . LEU A 1 322 ? 21.392 -32.1   -28.842 1    19.49  ? 321  LEU A N   1 
ATOM   2520 C  CA  . LEU A 1 322 ? 20.604 -33.33  -28.784 1    19.85  ? 321  LEU A CA  1 
ATOM   2521 C  C   . LEU A 1 322 ? 21.069 -34.315 -29.889 1    20.65  ? 321  LEU A C   1 
ATOM   2522 O  O   . LEU A 1 322 ? 21.27  -35.495 -29.606 1    20.74  ? 321  LEU A O   1 
ATOM   2523 C  CB  . LEU A 1 322 ? 19.129 -33.019 -28.987 1    19.46  ? 321  LEU A CB  1 
ATOM   2524 C  CG  . LEU A 1 322 ? 18.445 -32.198 -27.877 1    21.24  ? 321  LEU A CG  1 
ATOM   2525 C  CD1 . LEU A 1 322 ? 16.936 -31.992 -28.258 1    23.02  ? 321  LEU A CD1 1 
ATOM   2526 C  CD2 . LEU A 1 322 ? 18.631 -32.864 -26.476 1    23.47  ? 321  LEU A CD2 1 
ATOM   2527 N  N   . ASP A 1 323 ? 21.244 -33.822 -31.115 1    20.04  ? 322  ASP A N   1 
ATOM   2528 C  CA  . ASP A 1 323 ? 21.699 -34.659 -32.258 1    20.26  ? 322  ASP A CA  1 
ATOM   2529 C  C   . ASP A 1 323 ? 23.034 -35.36  -31.92  1    20.44  ? 322  ASP A C   1 
ATOM   2530 O  O   . ASP A 1 323 ? 23.119 -36.571 -32.095 1    21.57  ? 322  ASP A O   1 
ATOM   2531 C  CB  . ASP A 1 323 ? 21.947 -33.785 -33.496 1    21.31  ? 322  ASP A CB  1 
ATOM   2532 C  CG  . ASP A 1 323 ? 20.7   -33.163 -34.132 1    24.95  ? 322  ASP A CG  1 
ATOM   2533 O  OD1 . ASP A 1 323 ? 19.589 -33.676 -33.884 1    25.36  ? 322  ASP A OD1 1 
ATOM   2534 O  OD2 . ASP A 1 323 ? 20.853 -32.206 -34.94  1    28.04  ? 322  ASP A OD2 1 
ATOM   2535 N  N   . LYS A 1 324 ? 24.042 -34.62  -31.398 1    19.18  ? 323  LYS A N   1 
ATOM   2536 C  CA  . LYS A 1 324 ? 25.35  -35.219 -31.108 1    20.95  ? 323  LYS A CA  1 
ATOM   2537 C  C   . LYS A 1 324 ? 25.264 -36.241 -29.99  1    21.89  ? 323  LYS A C   1 
ATOM   2538 O  O   . LYS A 1 324 ? 26.002 -37.232 -30.032 1    23.47  ? 323  LYS A O   1 
ATOM   2539 C  CB  . LYS A 1 324 ? 26.427 -34.19  -30.783 1    22.79  ? 323  LYS A CB  1 
ATOM   2540 C  CG  . LYS A 1 324 ? 26.602 -33.106 -31.849 1    29.33  ? 323  LYS A CG  1 
ATOM   2541 C  CD  . LYS A 1 324 ? 27.156 -33.659 -33.116 1    35.11  ? 323  LYS A CD  1 
ATOM   2542 C  CE  . LYS A 1 324 ? 27.45  -32.549 -34.119 1    40.12  ? 323  LYS A CE  1 
ATOM   2543 N  NZ  . LYS A 1 324 ? 28.742 -31.875 -33.841 1    42.91  ? 323  LYS A NZ  1 
ATOM   2544 N  N   . LEU A 1 325 ? 24.372 -36.017 -29.014 1    20.53  ? 324  LEU A N   1 
ATOM   2545 C  CA  . LEU A 1 325 ? 24.162 -36.982 -27.928 1    20.75  ? 324  LEU A CA  1 
ATOM   2546 C  C   . LEU A 1 325 ? 23.299 -38.193 -28.339 1    20.95  ? 324  LEU A C   1 
ATOM   2547 O  O   . LEU A 1 325 ? 23.15  -39.131 -27.561 1    21.3   ? 324  LEU A O   1 
ATOM   2548 C  CB  . LEU A 1 325 ? 23.49  -36.266 -26.754 1    22.37  ? 324  LEU A CB  1 
ATOM   2549 C  CG  . LEU A 1 325 ? 24.482 -35.66  -25.798 1    25.92  ? 324  LEU A CG  1 
ATOM   2550 C  CD1 . LEU A 1 325 ? 23.764 -34.733 -24.842 1    28.38  ? 324  LEU A CD1 1 
ATOM   2551 C  CD2 . LEU A 1 325 ? 25.116 -36.778 -24.976 1    25.74  ? 324  LEU A CD2 1 
ATOM   2552 N  N   . GLY A 1 326 ? 22.692 -38.136 -29.522 1    21.66  ? 325  GLY A N   1 
ATOM   2553 C  CA  . GLY A 1 326 ? 21.824 -39.195 -30.024 1    22.2   ? 325  GLY A CA  1 
ATOM   2554 C  C   . GLY A 1 326 ? 20.481 -39.197 -29.328 1    22.78  ? 325  GLY A C   1 
ATOM   2555 O  O   . GLY A 1 326 ? 19.849 -40.255 -29.209 1    23.54  ? 325  GLY A O   1 
ATOM   2556 N  N   . LEU A 1 327 ? 19.985 -37.99  -28.913 1    20.85  ? 326  LEU A N   1 
ATOM   2557 C  CA  . LEU A 1 327 ? 18.687 -37.862 -28.243 1    20.45  ? 326  LEU A CA  1 
ATOM   2558 C  C   . LEU A 1 327 ? 17.633 -37.315 -29.199 1    20.89  ? 326  LEU A C   1 
ATOM   2559 O  O   . LEU A 1 327 ? 17.808 -36.215 -29.718 1    20.22  ? 326  LEU A O   1 
ATOM   2560 C  CB  . LEU A 1 327 ? 18.774 -36.919 -27.019 1    20.52  ? 326  LEU A CB  1 
ATOM   2561 C  CG  . LEU A 1 327 ? 19.84  -37.317 -25.988 1    21.17  ? 326  LEU A CG  1 
ATOM   2562 C  CD1 . LEU A 1 327 ? 19.89  -36.291 -24.866 1    21.34  ? 326  LEU A CD1 1 
ATOM   2563 C  CD2 . LEU A 1 327 ? 19.507 -38.692 -25.394 1    23.35  ? 326  LEU A CD2 1 
ATOM   2564 N  N   . SER A 1 328 ? 16.573 -38.096 -29.472 1    21.73  ? 327  SER A N   1 
ATOM   2565 C  CA  . SER A 1 328 ? 15.514 -37.598 -30.359 1    22.53  ? 327  SER A CA  1 
ATOM   2566 C  C   . SER A 1 328 ? 14.714 -36.493 -29.667 1    22.96  ? 327  SER A C   1 
ATOM   2567 O  O   . SER A 1 328 ? 14.27  -35.55  -30.33  1    23.58  ? 327  SER A O   1 
ATOM   2568 C  CB  . SER A 1 328 ? 14.615 -38.728 -30.851 1    24.11  ? 327  SER A CB  1 
ATOM   2569 O  OG  . SER A 1 328 ? 14.062 -39.476 -29.786 1    25.65  ? 327  SER A OG  1 
ATOM   2570 N  N   . GLN A 1 329 ? 14.556 -36.577 -28.336 1    22.4   ? 328  GLN A N   1 
ATOM   2571 C  CA  . GLN A 1 329 ? 13.87  -35.521 -27.586 1    21.64  ? 328  GLN A CA  1 
ATOM   2572 C  C   . GLN A 1 329 ? 14.494 -35.362 -26.192 1    22.1   ? 328  GLN A C   1 
ATOM   2573 O  O   . GLN A 1 329 ? 15.136 -36.284 -25.654 1    22.19  ? 328  GLN A O   1 
ATOM   2574 C  CB  . GLN A 1 329 ? 12.398 -35.885 -27.324 1    21.9   ? 328  GLN A CB  1 
ATOM   2575 C  CG  . GLN A 1 329 ? 11.54  -36.048 -28.558 1    24.34  ? 328  GLN A CG  1 
ATOM   2576 C  CD  . GLN A 1 329 ? 10.093 -36.217 -28.173 1    25.84  ? 328  GLN A CD  1 
ATOM   2577 O  OE1 . GLN A 1 329 ? 9.728  -36.941 -27.215 1    27.07  ? 328  GLN A OE1 1 
ATOM   2578 N  NE2 . GLN A 1 329 ? 9.226  -35.577 -28.95  1    25.38  ? 328  GLN A NE2 1 
ATOM   2579 N  N   . ALA A 1 330 ? 14.161 -34.242 -25.544 1    21.65  ? 329  ALA A N   1 
ATOM   2580 C  CA  . ALA A 1 330 ? 14.421 -34.075 -24.126 1    21.65  ? 329  ALA A CA  1 
ATOM   2581 C  C   . ALA A 1 330 ? 13.281 -33.209 -23.584 1    20.53  ? 329  ALA A C   1 
ATOM   2582 O  O   . ALA A 1 330 ? 12.625 -32.462 -24.338 1    20.57  ? 329  ALA A O   1 
ATOM   2583 C  CB  . ALA A 1 330 ? 15.761 -33.375 -23.882 1    21.85  ? 329  ALA A CB  1 
ATOM   2584 N  N   . VAL A 1 331 ? 13.031 -33.322 -22.287 1    19.84  ? 330  VAL A N   1 
ATOM   2585 C  CA  . VAL A 1 331 ? 12.154 -32.388 -21.613 1    20.06  ? 330  VAL A CA  1 
ATOM   2586 C  C   . VAL A 1 331 ? 13.054 -31.129 -21.409 1    21.11  ? 330  VAL A C   1 
ATOM   2587 O  O   . VAL A 1 331 ? 14.219 -31.298 -21.053 1    22.78  ? 330  VAL A O   1 
ATOM   2588 C  CB  . VAL A 1 331 ? 11.707 -32.941 -20.239 1    21.29  ? 330  VAL A CB  1 
ATOM   2589 C  CG1 . VAL A 1 331 ? 11.001 -31.861 -19.423 1    21.34  ? 330  VAL A CG1 1 
ATOM   2590 C  CG2 . VAL A 1 331 ? 10.812 -34.185 -20.415 1    22.89  ? 330  VAL A CG2 1 
ATOM   2591 N  N   . PHE A 1 332 ? 12.553 -29.915 -21.66  1    20.3   ? 331  PHE A N   1 
ATOM   2592 C  CA  . PHE A 1 332 ? 13.358 -28.715 -21.443 1    19.4   ? 331  PHE A CA  1 
ATOM   2593 C  C   . PHE A 1 332 ? 12.75  -27.944 -20.288 1    19.62  ? 331  PHE A C   1 
ATOM   2594 O  O   . PHE A 1 332 ? 11.59  -27.551 -20.357 1    20.58  ? 331  PHE A O   1 
ATOM   2595 C  CB  . PHE A 1 332 ? 13.405 -27.843 -22.707 1    19.9   ? 331  PHE A CB  1 
ATOM   2596 C  CG  . PHE A 1 332 ? 14.411 -28.382 -23.69  1    21.16  ? 331  PHE A CG  1 
ATOM   2597 C  CD1 . PHE A 1 332 ? 14.068 -29.393 -24.576 1    21.83  ? 331  PHE A CD1 1 
ATOM   2598 C  CD2 . PHE A 1 332 ? 15.698 -27.871 -23.743 1    22.87  ? 331  PHE A CD2 1 
ATOM   2599 C  CE1 . PHE A 1 332 ? 15.006 -29.884 -25.49  1    22.66  ? 331  PHE A CE1 1 
ATOM   2600 C  CE2 . PHE A 1 332 ? 16.631 -28.371 -24.634 1    23.82  ? 331  PHE A CE2 1 
ATOM   2601 C  CZ  . PHE A 1 332 ? 16.271 -29.364 -25.526 1    22.73  ? 331  PHE A CZ  1 
ATOM   2602 N  N   . ILE A 1 333 ? 13.57  -27.665 -19.27  1    17.95  ? 332  ILE A N   1 
ATOM   2603 C  CA  . ILE A 1 333 ? 13.149 -26.86  -18.124 1    19.36  ? 332  ILE A CA  1 
ATOM   2604 C  C   . ILE A 1 333 ? 14.093 -25.7   -18.024 1    19.73  ? 332  ILE A C   1 
ATOM   2605 O  O   . ILE A 1 333 ? 15.299 -25.924 -17.921 1    20.28  ? 332  ILE A O   1 
ATOM   2606 C  CB  . ILE A 1 333 ? 13.186 -27.677 -16.817 1    19.99  ? 332  ILE A CB  1 
ATOM   2607 C  CG1 . ILE A 1 333 ? 12.303 -28.956 -16.992 1    20.96  ? 332  ILE A CG1 1 
ATOM   2608 C  CG2 . ILE A 1 333 ? 12.653 -26.794 -15.673 1    20.85  ? 332  ILE A CG2 1 
ATOM   2609 C  CD1 . ILE A 1 333 ? 12.14  -29.866 -15.704 1    22.86  ? 332  ILE A CD1 1 
ATOM   2610 N  N   . GLY A 1 334 ? 13.555 -24.5   -18.023 1    19.51  ? 333  GLY A N   1 
ATOM   2611 C  CA  . GLY A 1 334 ? 14.397 -23.308 -17.975 1    20.32  ? 333  GLY A CA  1 
ATOM   2612 C  C   . GLY A 1 334 ? 14.012 -22.331 -16.884 1    21.25  ? 333  GLY A C   1 
ATOM   2613 O  O   . GLY A 1 334 ? 12.887 -22.347 -16.398 1    22.37  ? 333  GLY A O   1 
ATOM   2614 N  N   . HIS A 1 335 ? 14.946 -21.451 -16.517 1    20.37  ? 334  HIS A N   1 
ATOM   2615 C  CA  . HIS A 1 335 ? 14.668 -20.387 -15.531 1    20.05  ? 334  HIS A CA  1 
ATOM   2616 C  C   . HIS A 1 335 ? 15.254 -19.075 -16.097 1    21.29  ? 334  HIS A C   1 
ATOM   2617 O  O   . HIS A 1 335 ? 16.333 -19.118 -16.714 1    20.81  ? 334  HIS A O   1 
ATOM   2618 C  CB  . HIS A 1 335 ? 15.35  -20.73  -14.194 1    19.95  ? 334  HIS A CB  1 
ATOM   2619 C  CG  . HIS A 1 335 ? 15.368 -19.567 -13.226 1    22     ? 334  HIS A CG  1 
ATOM   2620 N  ND1 . HIS A 1 335 ? 16.555 -18.887 -12.921 1    22.16  ? 334  HIS A ND1 1 
ATOM   2621 C  CD2 . HIS A 1 335 ? 14.336 -18.983 -12.561 1    23.23  ? 334  HIS A CD2 1 
ATOM   2622 C  CE1 . HIS A 1 335 ? 16.214 -17.942 -12.043 1    23.13  ? 334  HIS A CE1 1 
ATOM   2623 N  NE2 . HIS A 1 335 ? 14.886 -17.947 -11.807 1    23.69  ? 334  HIS A NE2 1 
ATOM   2624 N  N   . ASP A 1 336 ? 14.498 -17.966 -16.029 1    21.21  ? 335  ASP A N   1 
ATOM   2625 C  CA  . ASP A 1 336 ? 15.005 -16.649 -16.494 1    20.75  ? 335  ASP A CA  1 
ATOM   2626 C  C   . ASP A 1 336 ? 15.33  -16.698 -18.016 1    21.6   ? 335  ASP A C   1 
ATOM   2627 O  O   . ASP A 1 336 ? 14.455 -17.166 -18.766 1    21.92  ? 335  ASP A O   1 
ATOM   2628 C  CB  . ASP A 1 336 ? 16.196 -16.205 -15.586 1    21.53  ? 335  ASP A CB  1 
ATOM   2629 C  CG  . ASP A 1 336 ? 16.708 -14.8   -15.927 1    24.65  ? 335  ASP A CG  1 
ATOM   2630 O  OD1 . ASP A 1 336 ? 16.042 -13.823 -15.531 1    26.2   ? 335  ASP A OD1 1 
ATOM   2631 O  OD2 . ASP A 1 336 ? 17.773 -14.69  -16.624 1    23.56  ? 335  ASP A OD2 1 
ATOM   2632 N  N   . TRP A 1 337 ? 16.551 -16.341 -18.477 1    20.81  ? 336  TRP A N   1 
ATOM   2633 C  CA  . TRP A 1 337 ? 16.868 -16.469 -19.908 1    20.64  ? 336  TRP A CA  1 
ATOM   2634 C  C   . TRP A 1 337 ? 16.706 -17.926 -20.418 1    19.09  ? 336  TRP A C   1 
ATOM   2635 O  O   . TRP A 1 337 ? 16.312 -18.129 -21.571 1    19.91  ? 336  TRP A O   1 
ATOM   2636 C  CB  . TRP A 1 337 ? 18.285 -15.93  -20.228 1    21.66  ? 336  TRP A CB  1 
ATOM   2637 C  CG  . TRP A 1 337 ? 18.243 -14.518 -20.722 1    23.51  ? 336  TRP A CG  1 
ATOM   2638 C  CD1 . TRP A 1 337 ? 18.823 -13.429 -20.145 1    25.67  ? 336  TRP A CD1 1 
ATOM   2639 C  CD2 . TRP A 1 337 ? 17.611 -14.048 -21.922 1    23.8   ? 336  TRP A CD2 1 
ATOM   2640 N  NE1 . TRP A 1 337 ? 18.544 -12.3   -20.882 1    26.1   ? 336  TRP A NE1 1 
ATOM   2641 C  CE2 . TRP A 1 337 ? 17.819 -12.657 -21.988 1    25.41  ? 336  TRP A CE2 1 
ATOM   2642 C  CE3 . TRP A 1 337 ? 16.872 -14.666 -22.932 1    24.49  ? 336  TRP A CE3 1 
ATOM   2643 C  CZ2 . TRP A 1 337 ? 17.296 -11.869 -23.021 1    26.52  ? 336  TRP A CZ2 1 
ATOM   2644 C  CZ3 . TRP A 1 337 ? 16.401 -13.893 -23.976 1    26.3   ? 336  TRP A CZ3 1 
ATOM   2645 C  CH2 . TRP A 1 337 ? 16.603 -12.508 -24.003 1    26.59  ? 336  TRP A CH2 1 
ATOM   2646 N  N   . GLY A 1 338 ? 16.991 -18.913 -19.565 1    18.91  ? 337  GLY A N   1 
ATOM   2647 C  CA  . GLY A 1 338 ? 16.79  -20.317 -19.949 1    19.88  ? 337  GLY A CA  1 
ATOM   2648 C  C   . GLY A 1 338 ? 15.309 -20.633 -20.177 1    21.13  ? 337  GLY A C   1 
ATOM   2649 O  O   . GLY A 1 338 ? 14.946 -21.407 -21.08  1    20.08  ? 337  GLY A O   1 
ATOM   2650 N  N   . GLY A 1 339 ? 14.433 -19.985 -19.402 1    20.68  ? 338  GLY A N   1 
ATOM   2651 C  CA  . GLY A 1 339 ? 12.988 -20.166 -19.57  1    22.24  ? 338  GLY A CA  1 
ATOM   2652 C  C   . GLY A 1 339 ? 12.52  -19.55  -20.87  1    22.76  ? 338  GLY A C   1 
ATOM   2653 O  O   . GLY A 1 339 ? 11.749 -20.172 -21.614 1    23.22  ? 338  GLY A O   1 
ATOM   2654 N  N   . MET A 1 340 ? 13.079 -18.383 -21.255 1    22.43  ? 339  MET A N   1 
ATOM   2655 C  CA  . MET A 1 340 ? 12.748 -17.788 -22.555 1    22.52  ? 339  MET A CA  1 
ATOM   2656 C  C   . MET A 1 340 ? 13.207 -18.75  -23.677 1    21.56  ? 339  MET A C   1 
ATOM   2657 O  O   . MET A 1 340 ? 12.45  -19.035 -24.611 1    21.86  ? 339  MET A O   1 
ATOM   2658 C  CB  . MET A 1 340 ? 13.417 -16.422 -22.721 1    23.43  ? 339  MET A CB  1 
ATOM   2659 C  CG  . MET A 1 340 ? 12.974 -15.731 -23.973 1    26.95  ? 339  MET A CG  1 
ATOM   2660 S  SD  . MET A 1 340 ? 11.247 -15.197 -23.851 1    34.31  ? 339  MET A SD  1 
ATOM   2661 C  CE  . MET A 1 340 ? 11.429 -13.913 -22.583 1    38.41  ? 339  MET A CE  1 
ATOM   2662 N  N   . LEU A 1 341 ? 14.404 -19.332 -23.519 1    20.19  ? 340  LEU A N   1 
ATOM   2663 C  CA  . LEU A 1 341 ? 14.921 -20.264 -24.511 1    20.17  ? 340  LEU A CA  1 
ATOM   2664 C  C   . LEU A 1 341 ? 14.008 -21.491 -24.665 1    20.51  ? 340  LEU A C   1 
ATOM   2665 O  O   . LEU A 1 341 ? 13.708 -21.881 -25.809 1    21.27  ? 340  LEU A O   1 
ATOM   2666 C  CB  . LEU A 1 341 ? 16.36  -20.682 -24.181 1    21.34  ? 340  LEU A CB  1 
ATOM   2667 C  CG  . LEU A 1 341 ? 16.993 -21.663 -25.203 1    25.32  ? 340  LEU A CG  1 
ATOM   2668 C  CD1 . LEU A 1 341 ? 18.488 -21.454 -25.352 1    27.15  ? 340  LEU A CD1 1 
ATOM   2669 C  CD2 . LEU A 1 341 ? 16.916 -23.098 -24.705 1    26.58  ? 340  LEU A CD2 1 
ATOM   2670 N  N   . VAL A 1 342 ? 13.562 -22.099 -23.534 1    20.16  ? 341  VAL A N   1 
ATOM   2671 C  CA  . VAL A 1 342 ? 12.753 -23.322 -23.669 1    21.12  ? 341  VAL A CA  1 
ATOM   2672 C  C   . VAL A 1 342 ? 11.385 -23.054 -24.318 1    21.21  ? 341  VAL A C   1 
ATOM   2673 O  O   . VAL A 1 342 ? 10.918 -23.933 -25.052 1    21.26  ? 341  VAL A O   1 
ATOM   2674 C  CB  . VAL A 1 342 ? 12.642 -24.156 -22.397 1    21.79  ? 341  VAL A CB  1 
ATOM   2675 C  CG1 . VAL A 1 342 ? 14.049 -24.445 -21.858 1    22.21  ? 341  VAL A CG1 1 
ATOM   2676 C  CG2 . VAL A 1 342 ? 11.783 -23.436 -21.34  1    22.47  ? 341  VAL A CG2 1 
ATOM   2677 N  N   . TRP A 1 343 ? 10.791 -21.863 -24.136 1    20.21  ? 342  TRP A N   1 
ATOM   2678 C  CA  . TRP A 1 343 ? 9.531  -21.567 -24.854 1    22.06  ? 342  TRP A CA  1 
ATOM   2679 C  C   . TRP A 1 343 ? 9.78   -21.519 -26.367 1    23.08  ? 342  TRP A C   1 
ATOM   2680 O  O   . TRP A 1 343 ? 8.985  -22.059 -27.136 1    23.41  ? 342  TRP A O   1 
ATOM   2681 C  CB  . TRP A 1 343 ? 8.898  -20.243 -24.407 1    22.06  ? 342  TRP A CB  1 
ATOM   2682 C  CG  . TRP A 1 343 ? 8.36   -20.231 -22.999 1    22.51  ? 342  TRP A CG  1 
ATOM   2683 C  CD1 . TRP A 1 343 ? 8.621  -19.297 -22.038 1    23.65  ? 342  TRP A CD1 1 
ATOM   2684 C  CD2 . TRP A 1 343 ? 7.409  -21.145 -22.425 1    22.97  ? 342  TRP A CD2 1 
ATOM   2685 N  NE1 . TRP A 1 343 ? 7.948  -19.611 -20.88  1    24.12  ? 342  TRP A NE1 1 
ATOM   2686 C  CE2 . TRP A 1 343 ? 7.201  -20.749 -21.087 1    24.13  ? 342  TRP A CE2 1 
ATOM   2687 C  CE3 . TRP A 1 343 ? 6.751  -22.293 -22.896 1    23.84  ? 342  TRP A CE3 1 
ATOM   2688 C  CZ2 . TRP A 1 343 ? 6.357  -21.456 -20.215 1    24.8   ? 342  TRP A CZ2 1 
ATOM   2689 C  CZ3 . TRP A 1 343 ? 5.94   -23.007 -22.03  1    24.44  ? 342  TRP A CZ3 1 
ATOM   2690 C  CH2 . TRP A 1 343 ? 5.72   -22.575 -20.72  1    24.3   ? 342  TRP A CH2 1 
ATOM   2691 N  N   . TYR A 1 344 ? 10.9   -20.916 -26.802 1    22.67  ? 343  TYR A N   1 
ATOM   2692 C  CA  . TYR A 1 344 ? 11.208 -20.85  -28.23  1    23.88  ? 343  TYR A CA  1 
ATOM   2693 C  C   . TYR A 1 344 ? 11.619 -22.233 -28.777 1    22.51  ? 343  TYR A C   1 
ATOM   2694 O  O   . TYR A 1 344 ? 11.262 -22.539 -29.916 1    22.8   ? 343  TYR A O   1 
ATOM   2695 C  CB  . TYR A 1 344 ? 12.199 -19.723 -28.548 1    25.38  ? 343  TYR A CB  1 
ATOM   2696 C  CG  . TYR A 1 344 ? 11.398 -18.443 -28.534 1    28.36  ? 343  TYR A CG  1 
ATOM   2697 C  CD1 . TYR A 1 344 ? 10.601 -18.095 -29.613 1    30.07  ? 343  TYR A CD1 1 
ATOM   2698 C  CD2 . TYR A 1 344 ? 11.264 -17.696 -27.37  1    30.58  ? 343  TYR A CD2 1 
ATOM   2699 C  CE1 . TYR A 1 344 ? 9.718  -17.02  -29.554 1    31.9   ? 343  TYR A CE1 1 
ATOM   2700 C  CE2 . TYR A 1 344 ? 10.394 -16.6   -27.305 1    31.91  ? 343  TYR A CE2 1 
ATOM   2701 C  CZ  . TYR A 1 344 ? 9.642  -16.249 -28.414 1    32.3   ? 343  TYR A CZ  1 
ATOM   2702 O  OH  . TYR A 1 344 ? 8.739  -15.198 -28.4   1    32.79  ? 343  TYR A OH  1 
ATOM   2703 N  N   . MET A 1 345 ? 12.191 -23.119 -27.934 1    21.5   ? 344  MET A N   1 
ATOM   2704 C  CA  . MET A 1 345 ? 12.452 -24.512 -28.379 1    21.24  ? 344  MET A CA  1 
ATOM   2705 C  C   . MET A 1 345 ? 11.085 -25.192 -28.643 1    21.33  ? 344  MET A C   1 
ATOM   2706 O  O   . MET A 1 345 ? 10.933 -25.886 -29.642 1    21.53  ? 344  MET A O   1 
ATOM   2707 C  CB  . MET A 1 345 ? 13.197 -25.327 -27.308 1    21.96  ? 344  MET A CB  1 
ATOM   2708 C  CG  . MET A 1 345 ? 14.665 -24.889 -27.089 1    22.38  ? 344  MET A CG  1 
ATOM   2709 S  SD  . MET A 1 345 ? 15.71  -25.249 -28.522 1    25.36  ? 344  MET A SD  1 
ATOM   2710 C  CE  . MET A 1 345 ? 15.661 -27.041 -28.513 1    24.61  ? 344  MET A CE  1 
ATOM   2711 N  N   . ALA A 1 346 ? 10.106 -24.958 -27.785 1    21.15  ? 345  ALA A N   1 
ATOM   2712 C  CA  . ALA A 1 346 ? 8.769  -25.549 -27.942 1    21.98  ? 345  ALA A CA  1 
ATOM   2713 C  C   . ALA A 1 346 ? 8.056  -25.003 -29.203 1    23.43  ? 345  ALA A C   1 
ATOM   2714 O  O   . ALA A 1 346 ? 7.431  -25.777 -29.94  1    23.81  ? 345  ALA A O   1 
ATOM   2715 C  CB  . ALA A 1 346 ? 7.916  -25.288 -26.705 1    21.72  ? 345  ALA A CB  1 
ATOM   2716 N  N   . LEU A 1 347 ? 8.262  -23.723 -29.51  1    23.5   ? 346  LEU A N   1 
ATOM   2717 C  CA  . LEU A 1 347 ? 7.643  -23.095 -30.69  1    24.55  ? 346  LEU A CA  1 
ATOM   2718 C  C   . LEU A 1 347 ? 8.297  -23.46  -32.041 1    25.07  ? 346  LEU A C   1 
ATOM   2719 O  O   . LEU A 1 347 ? 7.61   -23.493 -33.063 1    27.22  ? 346  LEU A O   1 
ATOM   2720 C  CB  . LEU A 1 347 ? 7.745  -21.572 -30.542 1    25.54  ? 346  LEU A CB  1 
ATOM   2721 C  CG  . LEU A 1 347 ? 6.645  -20.915 -29.765 1    28.87  ? 346  LEU A CG  1 
ATOM   2722 C  CD1 . LEU A 1 347 ? 7.02   -19.471 -29.433 1    29.95  ? 346  LEU A CD1 1 
ATOM   2723 C  CD2 . LEU A 1 347 ? 5.318  -20.998 -30.508 1    28.79  ? 346  LEU A CD2 1 
ATOM   2724 N  N   . PHE A 1 348 ? 9.623  -23.642 -32.068 1    23.54  ? 347  PHE A N   1 
ATOM   2725 C  CA  . PHE A 1 348 ? 10.333 -23.853 -33.311 1    23.11  ? 347  PHE A CA  1 
ATOM   2726 C  C   . PHE A 1 348 ? 10.759 -25.29  -33.542 1    22.73  ? 347  PHE A C   1 
ATOM   2727 O  O   . PHE A 1 348 ? 10.946 -25.657 -34.683 1    23.82  ? 347  PHE A O   1 
ATOM   2728 C  CB  . PHE A 1 348 ? 11.523 -22.883 -33.437 1    23.19  ? 347  PHE A CB  1 
ATOM   2729 C  CG  . PHE A 1 348 ? 11.13  -21.46  -33.813 1    23.31  ? 347  PHE A CG  1 
ATOM   2730 C  CD1 . PHE A 1 348 ? 10.702 -20.563 -32.85  1    23.26  ? 347  PHE A CD1 1 
ATOM   2731 C  CD2 . PHE A 1 348 ? 11.234 -21.016 -35.129 1    24.5   ? 347  PHE A CD2 1 
ATOM   2732 C  CE1 . PHE A 1 348 ? 10.372 -19.239 -33.19  1    23.53  ? 347  PHE A CE1 1 
ATOM   2733 C  CE2 . PHE A 1 348 ? 10.895 -19.698 -35.477 1    24.3   ? 347  PHE A CE2 1 
ATOM   2734 C  CZ  . PHE A 1 348 ? 10.464 -18.82  -34.505 1    23.43  ? 347  PHE A CZ  1 
ATOM   2735 N  N   . TYR A 1 349 ? 10.928 -26.094 -32.465 1    20.63  ? 348  TYR A N   1 
ATOM   2736 C  CA  . TYR A 1 349 ? 11.36  -27.48  -32.553 1    21.54  ? 348  TYR A CA  1 
ATOM   2737 C  C   . TYR A 1 349 ? 10.511 -28.406 -31.675 1    21.61  ? 348  TYR A C   1 
ATOM   2738 O  O   . TYR A 1 349 ? 11.038 -29.175 -30.863 1    21.56  ? 348  TYR A O   1 
ATOM   2739 C  CB  . TYR A 1 349 ? 12.841 -27.562 -32.135 1    21.83  ? 348  TYR A CB  1 
ATOM   2740 C  CG  . TYR A 1 349 ? 13.726 -26.696 -32.994 1    23.46  ? 348  TYR A CG  1 
ATOM   2741 C  CD1 . TYR A 1 349 ? 14.092 -27.098 -34.27  1    25.49  ? 348  TYR A CD1 1 
ATOM   2742 C  CD2 . TYR A 1 349 ? 14.188 -25.471 -32.538 1    24.73  ? 348  TYR A CD2 1 
ATOM   2743 C  CE1 . TYR A 1 349 ? 14.974 -26.346 -35.033 1    27.64  ? 348  TYR A CE1 1 
ATOM   2744 C  CE2 . TYR A 1 349 ? 15.015 -24.672 -33.327 1    26.31  ? 348  TYR A CE2 1 
ATOM   2745 C  CZ  . TYR A 1 349 ? 15.394 -25.108 -34.579 1    28.91  ? 348  TYR A CZ  1 
ATOM   2746 O  OH  . TYR A 1 349 ? 16.259 -24.371 -35.362 1    31.41  ? 348  TYR A OH  1 
ATOM   2747 N  N   . PRO A 1 350 ? 9.179  -28.36  -31.8   1    22.4   ? 349  PRO A N   1 
ATOM   2748 C  CA  . PRO A 1 350 ? 8.317  -29.22  -30.952 1    23.41  ? 349  PRO A CA  1 
ATOM   2749 C  C   . PRO A 1 350 ? 8.603  -30.716 -31.078 1    24.17  ? 349  PRO A C   1 
ATOM   2750 O  O   . PRO A 1 350 ? 8.447  -31.473 -30.091 1    23.63  ? 349  PRO A O   1 
ATOM   2751 C  CB  . PRO A 1 350 ? 6.893  -28.863 -31.408 1    24.32  ? 349  PRO A CB  1 
ATOM   2752 C  CG  . PRO A 1 350 ? 7.089  -28.366 -32.823 1    24.73  ? 349  PRO A CG  1 
ATOM   2753 C  CD  . PRO A 1 350 ? 8.378  -27.558 -32.74  1    22.1   ? 349  PRO A CD  1 
ATOM   2754 N  N   . GLU A 1 351 ? 9.111  -31.128 -32.24  1    23.74  ? 350  GLU A N   1 
ATOM   2755 C  CA  . GLU A 1 351 ? 9.422  -32.541 -32.456 1    23.91  ? 350  GLU A CA  1 
ATOM   2756 C  C   . GLU A 1 351 ? 10.572 -33.033 -31.514 1    23.19  ? 350  GLU A C   1 
ATOM   2757 O  O   . GLU A 1 351 ? 10.626 -34.207 -31.202 1    23.44  ? 350  GLU A O   1 
ATOM   2758 C  CB  . GLU A 1 351 ? 9.758  -32.792 -33.928 1    26.2   ? 350  GLU A CB  1 
ATOM   2759 C  CG  . GLU A 1 351 ? 11.148 -32.323 -34.336 1    33.78  ? 350  GLU A CG  1 
ATOM   2760 C  CD  . GLU A 1 351 ? 11.33  -30.891 -34.822 1    41.31  ? 350  GLU A CD  1 
ATOM   2761 O  OE1 . GLU A 1 351 ? 10.358 -30.092 -34.724 1    38     ? 350  GLU A OE1 1 
ATOM   2762 O  OE2 . GLU A 1 351 ? 12.429 -30.591 -35.363 1    42.09  ? 350  GLU A OE2 1 
ATOM   2763 N  N   . ARG A 1 352 ? 11.421 -32.108 -31.04  1    21.74  ? 351  ARG A N   1 
ATOM   2764 C  CA  . ARG A 1 352 ? 12.57  -32.434 -30.177 1    21.71  ? 351  ARG A CA  1 
ATOM   2765 C  C   . ARG A 1 352 ? 12.301 -32.162 -28.692 1    21.82  ? 351  ARG A C   1 
ATOM   2766 O  O   . ARG A 1 352 ? 13.159 -32.436 -27.863 1    23.27  ? 351  ARG A O   1 
ATOM   2767 C  CB  . ARG A 1 352 ? 13.793 -31.592 -30.61  1    20.6   ? 351  ARG A CB  1 
ATOM   2768 C  CG  . ARG A 1 352 ? 14.11  -31.591 -32.116 1    22.09  ? 351  ARG A CG  1 
ATOM   2769 C  CD  . ARG A 1 352 ? 14.254 -33.009 -32.694 1    22.28  ? 351  ARG A CD  1 
ATOM   2770 N  NE  . ARG A 1 352 ? 15.379 -33.749 -32.116 1    21.85  ? 351  ARG A NE  1 
ATOM   2771 C  CZ  . ARG A 1 352 ? 16.637 -33.622 -32.527 1    22.57  ? 351  ARG A CZ  1 
ATOM   2772 N  NH1 . ARG A 1 352 ? 16.936 -32.805 -33.531 1    22.88  ? 351  ARG A NH1 1 
ATOM   2773 N  NH2 . ARG A 1 352 ? 17.601 -34.342 -31.964 1    23.67  ? 351  ARG A NH2 1 
ATOM   2774 N  N   . VAL A 1 353 ? 11.158 -31.57  -28.362 1    20.91  ? 352  VAL A N   1 
ATOM   2775 C  CA  . VAL A 1 353 ? 10.833 -31.225 -26.996 1    21.64  ? 352  VAL A CA  1 
ATOM   2776 C  C   . VAL A 1 353 ? 9.737  -32.146 -26.513 1    21.7   ? 352  VAL A C   1 
ATOM   2777 O  O   . VAL A 1 353 ? 8.588  -32.05  -26.972 1    21.52  ? 352  VAL A O   1 
ATOM   2778 C  CB  . VAL A 1 353 ? 10.416 -29.733 -26.935 1    22.98  ? 352  VAL A CB  1 
ATOM   2779 C  CG1 . VAL A 1 353 ? 10.074 -29.317 -25.501 1    23.17  ? 352  VAL A CG1 1 
ATOM   2780 C  CG2 . VAL A 1 353 ? 11.523 -28.828 -27.506 1    24.05  ? 352  VAL A CG2 1 
ATOM   2781 N  N   . ARG A 1 354 ? 10.081 -33.027 -25.577 1    21.49  ? 353  ARG A N   1 
ATOM   2782 C  CA  . ARG A 1 354 ? 9.112  -33.95  -25.015 1    22.4   ? 353  ARG A CA  1 
ATOM   2783 C  C   . ARG A 1 354 ? 8.031  -33.191 -24.211 1    22.94  ? 353  ARG A C   1 
ATOM   2784 O  O   . ARG A 1 354 ? 6.854  -33.545 -24.227 1    22.81  ? 353  ARG A O   1 
ATOM   2785 C  CB  . ARG A 1 354 ? 9.848  -34.996 -24.142 1    24.34  ? 353  ARG A CB  1 
ATOM   2786 C  CG  . ARG A 1 354 ? 8.925  -35.936 -23.365 1    28.97  ? 353  ARG A CG  1 
ATOM   2787 C  CD  . ARG A 1 354 ? 7.989  -36.727 -24.276 1    34.6   ? 353  ARG A CD  1 
ATOM   2788 N  NE  . ARG A 1 354 ? 7.076  -37.591 -23.506 1    40.97  ? 353  ARG A NE  1 
ATOM   2789 C  CZ  . ARG A 1 354 ? 5.917  -37.196 -22.986 1    45.2   ? 353  ARG A CZ  1 
ATOM   2790 N  NH1 . ARG A 1 354 ? 5.511  -35.939 -23.125 1    43.66  ? 353  ARG A NH1 1 
ATOM   2791 N  NH2 . ARG A 1 354 ? 5.148  -38.059 -22.329 1    46.59  ? 353  ARG A NH2 1 
ATOM   2792 N  N   . ALA A 1 355 ? 8.442  -32.15  -23.474 1    21.46  ? 354  ALA A N   1 
ATOM   2793 C  CA  . ALA A 1 355 ? 7.597  -31.324 -22.625 1    21.1   ? 354  ALA A CA  1 
ATOM   2794 C  C   . ALA A 1 355 ? 8.465  -30.085 -22.266 1    20.99  ? 354  ALA A C   1 
ATOM   2795 O  O   . ALA A 1 355 ? 9.699  -30.132 -22.341 1    19.95  ? 354  ALA A O   1 
ATOM   2796 C  CB  . ALA A 1 355 ? 7.187  -32.07  -21.35  1    22.34  ? 354  ALA A CB  1 
ATOM   2797 N  N   . VAL A 1 356 ? 7.802  -29.007 -21.853 1    20.94  ? 355  VAL A N   1 
ATOM   2798 C  CA  . VAL A 1 356 ? 8.521  -27.776 -21.568 1    20.39  ? 355  VAL A CA  1 
ATOM   2799 C  C   . VAL A 1 356 ? 8.06   -27.157 -20.258 1    21.54  ? 355  VAL A C   1 
ATOM   2800 O  O   . VAL A 1 356 ? 6.858  -27.132 -19.989 1    22.05  ? 355  VAL A O   1 
ATOM   2801 C  CB  . VAL A 1 356 ? 8.417  -26.808 -22.782 1    21.54  ? 355  VAL A CB  1 
ATOM   2802 C  CG1 . VAL A 1 356 ? 6.947  -26.497 -23.134 1    20.65  ? 355  VAL A CG1 1 
ATOM   2803 C  CG2 . VAL A 1 356 ? 9.176  -25.514 -22.5   1    23.36  ? 355  VAL A CG2 1 
ATOM   2804 N  N   . ALA A 1 357 ? 9.001  -26.65  -19.437 1    20.51  ? 356  ALA A N   1 
ATOM   2805 C  CA  . ALA A 1 357 ? 8.613  -25.987 -18.198 1    20.72  ? 356  ALA A CA  1 
ATOM   2806 C  C   . ALA A 1 357 ? 9.48   -24.751 -18.011 1    21.48  ? 356  ALA A C   1 
ATOM   2807 O  O   . ALA A 1 357 ? 10.692 -24.808 -18.244 1    20.82  ? 356  ALA A O   1 
ATOM   2808 C  CB  . ALA A 1 357 ? 8.786  -26.922 -17.008 1    21.06  ? 356  ALA A CB  1 
ATOM   2809 N  N   . SER A 1 358 ? 8.875  -23.67  -17.548 1    21.67  ? 357  SER A N   1 
ATOM   2810 C  CA  . SER A 1 358 ? 9.625  -22.456 -17.237 1    21.65  ? 357  SER A CA  1 
ATOM   2811 C  C   . SER A 1 358 ? 9.373  -22.03  -15.782 1    22.52  ? 357  SER A C   1 
ATOM   2812 O  O   . SER A 1 358 ? 8.235  -22.076 -15.304 1    23.56  ? 357  SER A O   1 
ATOM   2813 C  CB  . SER A 1 358 ? 9.208  -21.31  -18.158 1    22.95  ? 357  SER A CB  1 
ATOM   2814 O  OG  . SER A 1 358 ? 9.91   -20.122 -17.801 1    25.6   ? 357  SER A OG  1 
ATOM   2815 N  N   . LEU A 1 359 ? 10.446 -21.626 -15.094 1    21.77  ? 358  LEU A N   1 
ATOM   2816 C  CA  . LEU A 1 359 ? 10.405 -21.034 -13.765 1    22.61  ? 358  LEU A CA  1 
ATOM   2817 C  C   . LEU A 1 359 ? 10.525 -19.52  -14.006 1    22.57  ? 358  LEU A C   1 
ATOM   2818 O  O   . LEU A 1 359 ? 11.508 -19.046 -14.573 1    22.91  ? 358  LEU A O   1 
ATOM   2819 C  CB  . LEU A 1 359 ? 11.571 -21.497 -12.88  1    23.19  ? 358  LEU A CB  1 
ATOM   2820 C  CG  . LEU A 1 359 ? 11.748 -23.007 -12.644 1    24.84  ? 358  LEU A CG  1 
ATOM   2821 C  CD1 . LEU A 1 359 ? 12.879 -23.264 -11.708 1    24.38  ? 358  LEU A CD1 1 
ATOM   2822 C  CD2 . LEU A 1 359 ? 10.501 -23.649 -12.095 1    27.15  ? 358  LEU A CD2 1 
ATOM   2823 N  N   . ASN A 1 360 ? 9.49   -18.77  -13.593 1    22.24  ? 359  ASN A N   1 
ATOM   2824 C  CA  . ASN A 1 360 ? 9.417  -17.31  -13.574 1    23.4   ? 359  ASN A CA  1 
ATOM   2825 C  C   . ASN A 1 360 ? 9.166  -16.641 -14.922 1    24.22  ? 359  ASN A C   1 
ATOM   2826 O  O   . ASN A 1 360 ? 8.391  -15.681 -14.989 1    25.55  ? 359  ASN A O   1 
ATOM   2827 C  CB  . ASN A 1 360 ? 10.678 -16.683 -12.913 1    23.73  ? 359  ASN A CB  1 
ATOM   2828 C  CG  . ASN A 1 360 ? 11.03  -17.224 -11.539 1    26.78  ? 359  ASN A CG  1 
ATOM   2829 O  OD1 . ASN A 1 360 ? 11.06  -18.444 -11.293 1    28     ? 359  ASN A OD1 1 
ATOM   2830 N  ND2 . ASN A 1 360 ? 11.345 -16.335 -10.59  1    26.31  ? 359  ASN A ND2 1 
ATOM   2831 N  N   . THR A 1 361 ? 9.859  -17.076 -15.988 1    23.44  ? 360  THR A N   1 
ATOM   2832 C  CA  . THR A 1 361 ? 9.752  -16.426 -17.298 1    23.18  ? 360  THR A CA  1 
ATOM   2833 C  C   . THR A 1 361 ? 8.47   -16.798 -18.012 1    23.75  ? 360  THR A C   1 
ATOM   2834 O  O   . THR A 1 361 ? 8.236  -17.972 -18.321 1    23.65  ? 360  THR A O   1 
ATOM   2835 C  CB  . THR A 1 361 ? 10.92  -16.824 -18.191 1    24.92  ? 360  THR A CB  1 
ATOM   2836 O  OG1 . THR A 1 361 ? 12.113 -16.592 -17.474 1    26.6   ? 360  THR A OG1 1 
ATOM   2837 C  CG2 . THR A 1 361 ? 10.936 -16.073 -19.499 1    24.77  ? 360  THR A CG2 1 
ATOM   2838 N  N   . PRO A 1 362 ? 7.621  -15.804 -18.27  1    24.72  ? 361  PRO A N   1 
ATOM   2839 C  CA  . PRO A 1 362 ? 6.367  -16.107 -18.967 1    25.37  ? 361  PRO A CA  1 
ATOM   2840 C  C   . PRO A 1 362 ? 6.57   -16.221 -20.477 1    25.99  ? 361  PRO A C   1 
ATOM   2841 O  O   . PRO A 1 362 ? 7.613  -15.803 -21.017 1    26.5   ? 361  PRO A O   1 
ATOM   2842 C  CB  . PRO A 1 362 ? 5.499  -14.895 -18.627 1    26.11  ? 361  PRO A CB  1 
ATOM   2843 C  CG  . PRO A 1 362 ? 6.489  -13.75  -18.632 1    27.53  ? 361  PRO A CG  1 
ATOM   2844 C  CD  . PRO A 1 362 ? 7.746  -14.355 -17.969 1    25.5   ? 361  PRO A CD  1 
ATOM   2845 N  N   . PHE A 1 363 ? 5.542  -16.746 -21.172 1    25.71  ? 362  PHE A N   1 
ATOM   2846 C  CA  . PHE A 1 363 ? 5.56   -16.742 -22.619 1    26.73  ? 362  PHE A CA  1 
ATOM   2847 C  C   . PHE A 1 363 ? 4.612  -15.622 -23.059 1    27.77  ? 362  PHE A C   1 
ATOM   2848 O  O   . PHE A 1 363 ? 3.389  -15.71  -22.851 1    27.81  ? 362  PHE A O   1 
ATOM   2849 C  CB  . PHE A 1 363 ? 5.149  -18.09  -23.232 1    27.2   ? 362  PHE A CB  1 
ATOM   2850 C  CG  . PHE A 1 363 ? 5.059  -17.957 -24.735 1    28.15  ? 362  PHE A CG  1 
ATOM   2851 C  CD1 . PHE A 1 363 ? 6.176  -17.603 -25.483 1    29.2   ? 362  PHE A CD1 1 
ATOM   2852 C  CD2 . PHE A 1 363 ? 3.837  -18.032 -25.382 1    29.62  ? 362  PHE A CD2 1 
ATOM   2853 C  CE1 . PHE A 1 363 ? 6.077  -17.373 -26.86  1    30.01  ? 362  PHE A CE1 1 
ATOM   2854 C  CE2 . PHE A 1 363 ? 3.746  -17.844 -26.77  1    29.99  ? 362  PHE A CE2 1 
ATOM   2855 C  CZ  . PHE A 1 363 ? 4.856  -17.499 -27.495 1    29.86  ? 362  PHE A CZ  1 
ATOM   2856 N  N   . ILE A 1 364 ? 5.168  -14.549 -23.624 1    27.22  ? 363  ILE A N   1 
ATOM   2857 C  CA  . ILE A 1 364 ? 4.359  -13.444 -24.117 1    28.64  ? 363  ILE A CA  1 
ATOM   2858 C  C   . ILE A 1 364 ? 4.702  -13.264 -25.579 1    29.43  ? 363  ILE A C   1 
ATOM   2859 O  O   . ILE A 1 364 ? 5.855  -12.957 -25.895 1    30.15  ? 363  ILE A O   1 
ATOM   2860 C  CB  . ILE A 1 364 ? 4.61   -12.134 -23.325 1    29.37  ? 363  ILE A CB  1 
ATOM   2861 C  CG1 . ILE A 1 364 ? 4.195  -12.264 -21.833 1    31.24  ? 363  ILE A CG1 1 
ATOM   2862 C  CG2 . ILE A 1 364 ? 3.889  -10.959 -24.001 1    29.03  ? 363  ILE A CG2 1 
ATOM   2863 C  CD1 . ILE A 1 364 ? 4.867  -11.3   -20.957 1    32.8   ? 363  ILE A CD1 1 
ATOM   2864 N  N   . PRO A 1 365 ? 3.761  -13.526 -26.508 1    29.61  ? 364  PRO A N   1 
ATOM   2865 C  CA  . PRO A 1 365 ? 4.087  -13.408 -27.931 1    29.47  ? 364  PRO A CA  1 
ATOM   2866 C  C   . PRO A 1 365 ? 4.597  -12.023 -28.308 1    28.31  ? 364  PRO A C   1 
ATOM   2867 O  O   . PRO A 1 365 ? 4.177  -11.027 -27.703 1    28.2   ? 364  PRO A O   1 
ATOM   2868 C  CB  . PRO A 1 365 ? 2.754  -13.727 -28.621 1    31.04  ? 364  PRO A CB  1 
ATOM   2869 C  CG  . PRO A 1 365 ? 2.055  -14.646 -27.655 1    31.88  ? 364  PRO A CG  1 
ATOM   2870 C  CD  . PRO A 1 365 ? 2.373  -13.991 -26.317 1    30.12  ? 364  PRO A CD  1 
ATOM   2871 N  N   . ALA A 1 366 ? 5.519  -11.958 -29.265 1    27.81  ? 365  ALA A N   1 
ATOM   2872 C  CA  . ALA A 1 366 ? 6.073  -10.678 -29.723 1    28.82  ? 365  ALA A CA  1 
ATOM   2873 C  C   . ALA A 1 366 ? 4.951  -9.801  -30.319 1    29.7   ? 365  ALA A C   1 
ATOM   2874 O  O   . ALA A 1 366 ? 3.993  -10.313 -30.905 1    29.79  ? 365  ALA A O   1 
ATOM   2875 C  CB  . ALA A 1 366 ? 7.157  -10.914 -30.765 1    28.51  ? 365  ALA A CB  1 
ATOM   2876 N  N   . ASN A 1 367 ? 5.037  -8.49   -30.115 1    30.22  ? 366  ASN A N   1 
ATOM   2877 C  CA  . ASN A 1 367 ? 4.054  -7.553  -30.673 1    31.93  ? 366  ASN A CA  1 
ATOM   2878 C  C   . ASN A 1 367 ? 4.658  -7.069  -31.984 1    32.89  ? 366  ASN A C   1 
ATOM   2879 O  O   . ASN A 1 367 ? 5.703  -6.407  -31.981 1    33.12  ? 366  ASN A O   1 
ATOM   2880 C  CB  . ASN A 1 367 ? 3.865  -6.355  -29.727 1    34.13  ? 366  ASN A CB  1 
ATOM   2881 C  CG  . ASN A 1 367 ? 2.946  -5.274  -30.263 1    38.95  ? 366  ASN A CG  1 
ATOM   2882 O  OD1 . ASN A 1 367 ? 2.527  -5.29   -31.428 1    38.96  ? 366  ASN A OD1 1 
ATOM   2883 N  ND2 . ASN A 1 367 ? 2.618  -4.295  -29.409 1    40.73  ? 366  ASN A ND2 1 
ATOM   2884 N  N   . PRO A 1 368 ? 4.059  -7.433  -33.111 1    34.04  ? 367  PRO A N   1 
ATOM   2885 C  CA  . PRO A 1 368 ? 4.659  -7.076  -34.406 1    35.56  ? 367  PRO A CA  1 
ATOM   2886 C  C   . PRO A 1 368 ? 4.544  -5.592  -34.768 1    37.86  ? 367  PRO A C   1 
ATOM   2887 O  O   . PRO A 1 368 ? 5.119  -5.176  -35.76  1    38.9   ? 367  PRO A O   1 
ATOM   2888 C  CB  . PRO A 1 368 ? 3.875  -7.945  -35.386 1    35.51  ? 367  PRO A CB  1 
ATOM   2889 C  CG  . PRO A 1 368 ? 2.511  -8.014  -34.761 1    35.34  ? 367  PRO A CG  1 
ATOM   2890 C  CD  . PRO A 1 368 ? 2.815  -8.206  -33.289 1    33.9   ? 367  PRO A CD  1 
ATOM   2891 N  N   . ASN A 1 369 ? 3.804  -4.812  -33.971 1    39.65  ? 368  ASN A N   1 
ATOM   2892 C  CA  . ASN A 1 369 ? 3.579  -3.387  -34.198 1    42.38  ? 368  ASN A CA  1 
ATOM   2893 C  C   . ASN A 1 369 ? 4.4    -2.488  -33.26  1    44.92  ? 368  ASN A C   1 
ATOM   2894 O  O   . ASN A 1 369 ? 4.203  -1.271  -33.28  1    46.15  ? 368  ASN A O   1 
ATOM   2895 C  CB  . ASN A 1 369 ? 2.089  -3.072  -34.032 1    43.65  ? 368  ASN A CB  1 
ATOM   2896 C  CG  . ASN A 1 369 ? 1.215  -3.885  -34.948 1    47.27  ? 368  ASN A CG  1 
ATOM   2897 O  OD1 . ASN A 1 369 ? 1.37   -3.864  -36.177 1    48.72  ? 368  ASN A OD1 1 
ATOM   2898 N  ND2 . ASN A 1 369 ? 0.279  -4.63   -34.37  1    47.77  ? 368  ASN A ND2 1 
ATOM   2899 N  N   . MET A 1 370 ? 5.305  -3.053  -32.443 1    45.26  ? 369  MET A N   1 
ATOM   2900 C  CA  . MET A 1 370 ? 6.106  -2.235  -31.537 1    46.29  ? 369  MET A CA  1 
ATOM   2901 C  C   . MET A 1 370 ? 7.505  -2.805  -31.45  1    46.25  ? 369  MET A C   1 
ATOM   2902 O  O   . MET A 1 370 ? 7.666  -4.014  -31.298 1    44.94  ? 369  MET A O   1 
ATOM   2903 C  CB  . MET A 1 370 ? 5.461  -2.167  -30.144 1    48.56  ? 369  MET A CB  1 
ATOM   2904 C  CG  . MET A 1 370 ? 6.068  -1.1    -29.242 1    54.58  ? 369  MET A CG  1 
ATOM   2905 S  SD  . MET A 1 370 ? 5.337  -1.12   -27.574 1    68.81  ? 369  MET A SD  1 
ATOM   2906 C  CE  . MET A 1 370 ? 3.631  -0.677  -27.965 1    68.73  ? 369  MET A CE  1 
ATOM   2907 N  N   . SER A 1 371 ? 8.519  -1.935  -31.525 1    47.17  ? 370  SER A N   1 
ATOM   2908 C  CA  . SER A 1 371 ? 9.921  -2.36   -31.421 1    48.31  ? 370  SER A CA  1 
ATOM   2909 C  C   . SER A 1 371 ? 10.166 -2.901  -30.022 1    47.6   ? 370  SER A C   1 
ATOM   2910 O  O   . SER A 1 371 ? 9.622  -2.357  -29.064 1    47.71  ? 370  SER A O   1 
ATOM   2911 C  CB  . SER A 1 371 ? 10.851 -1.175  -31.684 1    51.3   ? 370  SER A CB  1 
ATOM   2912 O  OG  . SER A 1 371 ? 12.205 -1.462  -31.368 1    55.38  ? 370  SER A OG  1 
ATOM   2913 N  N   . PRO A 1 372 ? 10.964 -3.973  -29.867 1    47.18  ? 371  PRO A N   1 
ATOM   2914 C  CA  . PRO A 1 372 ? 11.224 -4.497  -28.509 1    47.6   ? 371  PRO A CA  1 
ATOM   2915 C  C   . PRO A 1 372 ? 11.805 -3.448  -27.556 1    48.76  ? 371  PRO A C   1 
ATOM   2916 O  O   . PRO A 1 372 ? 11.552 -3.505  -26.356 1    48.69  ? 371  PRO A O   1 
ATOM   2917 C  CB  . PRO A 1 372 ? 12.189 -5.669  -28.751 1    47.88  ? 371  PRO A CB  1 
ATOM   2918 C  CG  . PRO A 1 372 ? 12.765 -5.434  -30.107 1    48.14  ? 371  PRO A CG  1 
ATOM   2919 C  CD  . PRO A 1 372 ? 11.68  -4.749  -30.896 1    46.73  ? 371  PRO A CD  1 
ATOM   2920 N  N   . LEU A 1 373 ? 12.536 -2.464  -28.107 1    49.75  ? 372  LEU A N   1 
ATOM   2921 C  CA  . LEU A 1 373 ? 13.122 -1.345  -27.379 1    51.42  ? 372  LEU A CA  1 
ATOM   2922 C  C   . LEU A 1 373 ? 12.031 -0.515  -26.689 1    51.85  ? 372  LEU A C   1 
ATOM   2923 O  O   . LEU A 1 373 ? 12.181 -0.165  -25.517 1    52.2   ? 372  LEU A O   1 
ATOM   2924 C  CB  . LEU A 1 373 ? 13.92  -0.476  -28.373 1    52.71  ? 372  LEU A CB  1 
ATOM   2925 C  CG  . LEU A 1 373 ? 14.405 0.877   -27.873 1    55.74  ? 372  LEU A CG  1 
ATOM   2926 C  CD1 . LEU A 1 373 ? 15.542 0.706   -26.887 1    56.96  ? 372  LEU A CD1 1 
ATOM   2927 C  CD2 . LEU A 1 373 ? 14.824 1.762   -29.035 1    57.06  ? 372  LEU A CD2 1 
ATOM   2928 N  N   . GLU A 1 374 ? 10.93  -0.218  -27.399 1    51.55  ? 373  GLU A N   1 
ATOM   2929 C  CA  . GLU A 1 374 ? 9.845  0.575   -26.823 1    52.27  ? 373  GLU A CA  1 
ATOM   2930 C  C   . GLU A 1 374 ? 9.062  -0.218  -25.778 1    52.59  ? 373  GLU A C   1 
ATOM   2931 O  O   . GLU A 1 374 ? 8.627  0.354   -24.779 1    52.83  ? 373  GLU A O   1 
ATOM   2932 C  CB  . GLU A 1 374 ? 8.899  1.156   -27.891 1    55.46  ? 373  GLU A CB  1 
ATOM   2933 C  CG  . GLU A 1 374 ? 9.505  1.397   -29.267 1    63.14  ? 373  GLU A CG  1 
ATOM   2934 C  CD  . GLU A 1 374 ? 10.789 2.202   -29.363 1    73.02  ? 373  GLU A CD  1 
ATOM   2935 O  OE1 . GLU A 1 374 ? 11.01  3.103   -28.518 1    75.19  ? 373  GLU A OE1 1 
ATOM   2936 O  OE2 . GLU A 1 374 ? 11.576 1.927   -30.298 1    76.03  ? 373  GLU A OE2 1 
ATOM   2937 N  N   . SER A 1 375 ? 8.904  -1.533  -25.99  1    52.27  ? 374  SER A N   1 
ATOM   2938 C  CA  . SER A 1 375 ? 8.221  -2.392  -25.027 1    52.95  ? 374  SER A CA  1 
ATOM   2939 C  C   . SER A 1 375 ? 9.031  -2.458  -23.723 1    53.79  ? 374  SER A C   1 
ATOM   2940 O  O   . SER A 1 375 ? 8.454  -2.41   -22.633 1    54.32  ? 374  SER A O   1 
ATOM   2941 C  CB  . SER A 1 375 ? 8.041  -3.797  -25.599 1    54.05  ? 374  SER A CB  1 
ATOM   2942 O  OG  . SER A 1 375 ? 7.19   -3.809  -26.736 1    55.68  ? 374  SER A OG  1 
ATOM   2943 N  N   . ILE A 1 376 ? 10.372 -2.537  -23.83  1    53.63  ? 375  ILE A N   1 
ATOM   2944 C  CA  . ILE A 1 376 ? 11.243 -2.602  -22.654 1    54.06  ? 375  ILE A CA  1 
ATOM   2945 C  C   . ILE A 1 376 ? 11.231 -1.281  -21.882 1    54.64  ? 375  ILE A C   1 
ATOM   2946 O  O   . ILE A 1 376 ? 11.201 -1.289  -20.644 1    54.8   ? 375  ILE A O   1 
ATOM   2947 C  CB  . ILE A 1 376 ? 12.664 -3.087  -23.05  1    54.26  ? 375  ILE A CB  1 
ATOM   2948 C  CG1 . ILE A 1 376 ? 12.626 -4.599  -23.298 1    55.21  ? 375  ILE A CG1 1 
ATOM   2949 C  CG2 . ILE A 1 376 ? 13.721 -2.739  -21.997 1    54.54  ? 375  ILE A CG2 1 
ATOM   2950 C  CD1 . ILE A 1 376 ? 13.748 -5.118  -23.98  1    56.5   ? 375  ILE A CD1 1 
ATOM   2951 N  N   . LYS A 1 377 ? 11.189 -0.151  -22.612 1    54.63  ? 376  LYS A N   1 
ATOM   2952 C  CA  . LYS A 1 377 ? 11.152 1.181   -22.005 1    54.97  ? 376  LYS A CA  1 
ATOM   2953 C  C   . LYS A 1 377 ? 9.866  1.44    -21.204 1    54.7   ? 376  LYS A C   1 
ATOM   2954 O  O   . LYS A 1 377 ? 9.892  2.208   -20.242 1    54.91  ? 376  LYS A O   1 
ATOM   2955 C  CB  . LYS A 1 377 ? 11.339 2.273   -23.072 1    57.04  ? 376  LYS A CB  1 
ATOM   2956 C  CG  . LYS A 1 377 ? 12.787 2.47    -23.507 1    61.66  ? 376  LYS A CG  1 
ATOM   2957 C  CD  . LYS A 1 377 ? 12.899 3.545   -24.584 1    66.7   ? 376  LYS A CD  1 
ATOM   2958 C  CE  . LYS A 1 377 ? 14.304 3.646   -25.127 1    70.73  ? 376  LYS A CE  1 
ATOM   2959 N  NZ  . LYS A 1 377 ? 14.334 4.283   -26.475 1    73.44  ? 376  LYS A NZ  1 
ATOM   2960 N  N   . ALA A 1 378 ? 8.76   0.78    -21.576 1    54.1   ? 377  ALA A N   1 
ATOM   2961 C  CA  . ALA A 1 378 ? 7.468  0.955   -20.91  1    54.47  ? 377  ALA A CA  1 
ATOM   2962 C  C   . ALA A 1 378 ? 7.383  0.353   -19.491 1    54.68  ? 377  ALA A C   1 
ATOM   2963 O  O   . ALA A 1 378 ? 6.511  0.748   -18.711 1    55.51  ? 377  ALA A O   1 
ATOM   2964 C  CB  . ALA A 1 378 ? 6.353  0.395   -21.786 1    54.55  ? 377  ALA A CB  1 
ATOM   2965 N  N   . ASN A 1 379 ? 8.252  -0.613  -19.161 1    53.63  ? 378  ASN A N   1 
ATOM   2966 C  CA  . ASN A 1 379 ? 8.22   -1.245  -17.837 1    52.99  ? 378  ASN A CA  1 
ATOM   2967 C  C   . ASN A 1 379 ? 9.407  -0.786  -17.006 1    51.6   ? 378  ASN A C   1 
ATOM   2968 O  O   . ASN A 1 379 ? 10.541 -1.159  -17.299 1    51.63  ? 378  ASN A O   1 
ATOM   2969 C  CB  . ASN A 1 379 ? 8.222  -2.766  -17.962 1    54.66  ? 378  ASN A CB  1 
ATOM   2970 C  CG  . ASN A 1 379 ? 7.824  -3.489  -16.699 1    58.89  ? 378  ASN A CG  1 
ATOM   2971 O  OD1 . ASN A 1 379 ? 7.735  -2.907  -15.612 1    60.23  ? 378  ASN A OD1 1 
ATOM   2972 N  ND2 . ASN A 1 379 ? 7.57   -4.785  -16.816 1    59.79  ? 378  ASN A ND2 1 
ATOM   2973 N  N   . PRO A 1 380 ? 9.154  -0.013  -15.934 1    50.3   ? 379  PRO A N   1 
ATOM   2974 C  CA  . PRO A 1 380 ? 10.265 0.491   -15.107 1    49.34  ? 379  PRO A CA  1 
ATOM   2975 C  C   . PRO A 1 380 ? 11.208 -0.567  -14.532 1    48.15  ? 379  PRO A C   1 
ATOM   2976 O  O   . PRO A 1 380 ? 12.409 -0.301  -14.386 1    48.08  ? 379  PRO A O   1 
ATOM   2977 C  CB  . PRO A 1 380 ? 9.559  1.274   -13.988 1    50.33  ? 379  PRO A CB  1 
ATOM   2978 C  CG  . PRO A 1 380 ? 8.217  1.602   -14.532 1    50.95  ? 379  PRO A CG  1 
ATOM   2979 C  CD  . PRO A 1 380 ? 7.848  0.507   -15.478 1    49.55  ? 379  PRO A CD  1 
ATOM   2980 N  N   . VAL A 1 381 ? 10.677 -1.761  -14.192 1    46.71  ? 380  VAL A N   1 
ATOM   2981 C  CA  . VAL A 1 381 ? 11.519 -2.816  -13.624 1    45.91  ? 380  VAL A CA  1 
ATOM   2982 C  C   . VAL A 1 381 ? 12.509 -3.421  -14.641 1    44.44  ? 380  VAL A C   1 
ATOM   2983 O  O   . VAL A 1 381 ? 13.414 -4.142  -14.23  1    44.17  ? 380  VAL A O   1 
ATOM   2984 C  CB  . VAL A 1 381 ? 10.703 -3.922  -12.92  1    47.04  ? 380  VAL A CB  1 
ATOM   2985 C  CG1 . VAL A 1 381 ? 9.749  -3.326  -11.883 1    48.28  ? 380  VAL A CG1 1 
ATOM   2986 C  CG2 . VAL A 1 381 ? 9.954  -4.774  -13.936 1    47.27  ? 380  VAL A CG2 1 
ATOM   2987 N  N   . PHE A 1 382 ? 12.349 -3.118  -15.948 1    43.63  ? 381  PHE A N   1 
ATOM   2988 C  CA  . PHE A 1 382 ? 13.255 -3.6    -16.998 1    43.73  ? 381  PHE A CA  1 
ATOM   2989 C  C   . PHE A 1 382 ? 14.342 -2.565  -17.337 1    41.77  ? 381  PHE A C   1 
ATOM   2990 O  O   . PHE A 1 382 ? 14.976 -2.696  -18.379 1    40.54  ? 381  PHE A O   1 
ATOM   2991 C  CB  . PHE A 1 382 ? 12.49  -3.957  -18.296 1    44.89  ? 381  PHE A CB  1 
ATOM   2992 C  CG  . PHE A 1 382 ? 11.506 -5.11   -18.24  1    47.12  ? 381  PHE A CG  1 
ATOM   2993 C  CD1 . PHE A 1 382 ? 11.563 -6.044  -17.221 1    48.57  ? 381  PHE A CD1 1 
ATOM   2994 C  CD2 . PHE A 1 382 ? 10.555 -5.279  -19.231 1    48.82  ? 381  PHE A CD2 1 
ATOM   2995 C  CE1 . PHE A 1 382 ? 10.664 -7.107  -17.177 1    50.07  ? 381  PHE A CE1 1 
ATOM   2996 C  CE2 . PHE A 1 382 ? 9.649  -6.339  -19.18  1    50.13  ? 381  PHE A CE2 1 
ATOM   2997 C  CZ  . PHE A 1 382 ? 9.701  -7.238  -18.147 1    50.12  ? 381  PHE A CZ  1 
ATOM   2998 N  N   . ASP A 1 383 ? 14.574 -1.547  -16.477 1    41.52  ? 382  ASP A N   1 
ATOM   2999 C  CA  . ASP A 1 383 ? 15.61  -0.545  -16.757 1    41.58  ? 382  ASP A CA  1 
ATOM   3000 C  C   . ASP A 1 383 ? 17.026 -1.126  -16.773 1    40.34  ? 382  ASP A C   1 
ATOM   3001 O  O   . ASP A 1 383 ? 17.87  -0.673  -17.558 1    40.98  ? 382  ASP A O   1 
ATOM   3002 C  CB  . ASP A 1 383 ? 15.527 0.641   -15.792 1    44.77  ? 382  ASP A CB  1 
ATOM   3003 C  CG  . ASP A 1 383 ? 16.435 1.771   -16.22  1    51.43  ? 382  ASP A CG  1 
ATOM   3004 O  OD1 . ASP A 1 383 ? 16.181 2.362   -17.296 1    52.78  ? 382  ASP A OD1 1 
ATOM   3005 O  OD2 . ASP A 1 383 ? 17.432 2.034   -15.509 1    54.35  ? 382  ASP A OD2 1 
ATOM   3006 N  N   . TYR A 1 384 ? 17.283 -2.152  -15.957 1    38.01  ? 383  TYR A N   1 
ATOM   3007 C  CA  . TYR A 1 384 ? 18.602 -2.804  -15.956 1    36.99  ? 383  TYR A CA  1 
ATOM   3008 C  C   . TYR A 1 384 ? 18.94  -3.391  -17.358 1    34.78  ? 383  TYR A C   1 
ATOM   3009 O  O   . TYR A 1 384 ? 20.109 -3.462  -17.717 1    34.39  ? 383  TYR A O   1 
ATOM   3010 C  CB  . TYR A 1 384 ? 18.671 -3.886  -14.866 1    37.44  ? 383  TYR A CB  1 
ATOM   3011 C  CG  . TYR A 1 384 ? 17.9   -5.131  -15.229 1    38.85  ? 383  TYR A CG  1 
ATOM   3012 C  CD1 . TYR A 1 384 ? 16.522 -5.193  -15.067 1    39.97  ? 383  TYR A CD1 1 
ATOM   3013 C  CD2 . TYR A 1 384 ? 18.547 -6.243  -15.752 1    40.38  ? 383  TYR A CD2 1 
ATOM   3014 C  CE1 . TYR A 1 384 ? 15.808 -6.33   -15.418 1    41.31  ? 383  TYR A CE1 1 
ATOM   3015 C  CE2 . TYR A 1 384 ? 17.845 -7.376  -16.126 1    41.27  ? 383  TYR A CE2 1 
ATOM   3016 C  CZ  . TYR A 1 384 ? 16.476 -7.423  -15.952 1    43.23  ? 383  TYR A CZ  1 
ATOM   3017 O  OH  . TYR A 1 384 ? 15.797 -8.563  -16.317 1    46.36  ? 383  TYR A OH  1 
ATOM   3018 N  N   . GLN A 1 385 ? 17.917 -3.756  -18.164 1    33.14  ? 384  GLN A N   1 
ATOM   3019 C  CA  . GLN A 1 385 ? 18.161 -4.285  -19.505 1    33.07  ? 384  GLN A CA  1 
ATOM   3020 C  C   . GLN A 1 385 ? 18.753 -3.201  -20.418 1    33.18  ? 384  GLN A C   1 
ATOM   3021 O  O   . GLN A 1 385 ? 19.612 -3.507  -21.238 1    33.43  ? 384  GLN A O   1 
ATOM   3022 C  CB  . GLN A 1 385 ? 16.873 -4.849  -20.102 1    35.01  ? 384  GLN A CB  1 
ATOM   3023 C  CG  . GLN A 1 385 ? 16.251 -5.905  -19.185 1    39.46  ? 384  GLN A CG  1 
ATOM   3024 C  CD  . GLN A 1 385 ? 15.18  -6.737  -19.84  1    46.14  ? 384  GLN A CD  1 
ATOM   3025 O  OE1 . GLN A 1 385 ? 14.864 -6.582  -21.025 1    47.78  ? 384  GLN A OE1 1 
ATOM   3026 N  NE2 . GLN A 1 385 ? 14.594 -7.641  -19.061 1    47.67  ? 384  GLN A NE2 1 
ATOM   3027 N  N   . LEU A 1 386 ? 18.325 -1.933  -20.251 1    32.38  ? 385  LEU A N   1 
ATOM   3028 C  CA  . LEU A 1 386 ? 18.877 -0.848  -21.064 1    32.81  ? 385  LEU A CA  1 
ATOM   3029 C  C   . LEU A 1 386 ? 20.337 -0.596  -20.638 1    30.82  ? 385  LEU A C   1 
ATOM   3030 O  O   . LEU A 1 386 ? 21.201 -0.417  -21.495 1    31     ? 385  LEU A O   1 
ATOM   3031 C  CB  . LEU A 1 386 ? 18.023 0.435   -20.93  1    34.74  ? 385  LEU A CB  1 
ATOM   3032 C  CG  . LEU A 1 386 ? 16.535 0.267   -21.277 1    38.77  ? 385  LEU A CG  1 
ATOM   3033 C  CD1 . LEU A 1 386 ? 15.7   1.502   -20.858 1    40.24  ? 385  LEU A CD1 1 
ATOM   3034 C  CD2 . LEU A 1 386 ? 16.352 -0.049  -22.746 1    40.28  ? 385  LEU A CD2 1 
ATOM   3035 N  N   . TYR A 1 387 ? 20.624 -0.664  -19.323 1    29.53  ? 386  TYR A N   1 
ATOM   3036 C  CA  . TYR A 1 387 ? 21.981 -0.511  -18.807 1    29.3   ? 386  TYR A CA  1 
ATOM   3037 C  C   . TYR A 1 387 ? 22.904 -1.597  -19.395 1    28.31  ? 386  TYR A C   1 
ATOM   3038 O  O   . TYR A 1 387 ? 24.048 -1.321  -19.751 1    28.02  ? 386  TYR A O   1 
ATOM   3039 C  CB  . TYR A 1 387 ? 21.959 -0.609  -17.278 1    29.97  ? 386  TYR A CB  1 
ATOM   3040 C  CG  . TYR A 1 387 ? 23.33  -0.669  -16.639 1    31.35  ? 386  TYR A CG  1 
ATOM   3041 C  CD1 . TYR A 1 387 ? 24.158 0.447   -16.615 1    33.28  ? 386  TYR A CD1 1 
ATOM   3042 C  CD2 . TYR A 1 387 ? 23.763 -1.813  -15.983 1    32.24  ? 386  TYR A CD2 1 
ATOM   3043 C  CE1 . TYR A 1 387 ? 25.429 0.391   -16.05  1    34.19  ? 386  TYR A CE1 1 
ATOM   3044 C  CE2 . TYR A 1 387 ? 25.014 -1.87   -15.376 1    33.73  ? 386  TYR A CE2 1 
ATOM   3045 C  CZ  . TYR A 1 387 ? 25.852 -0.768  -15.42  1    35.63  ? 386  TYR A CZ  1 
ATOM   3046 O  OH  . TYR A 1 387 ? 27.092 -0.818  -14.812 1    37.49  ? 386  TYR A OH  1 
ATOM   3047 N  N   . PHE A 1 388 ? 22.377 -2.82   -19.564 1    27.18  ? 387  PHE A N   1 
ATOM   3048 C  CA  . PHE A 1 388 ? 23.167 -3.91   -20.151 1    27.14  ? 387  PHE A CA  1 
ATOM   3049 C  C   . PHE A 1 388 ? 23.418 -3.777  -21.678 1    27.93  ? 387  PHE A C   1 
ATOM   3050 O  O   . PHE A 1 388 ? 24.137 -4.612  -22.236 1    28.59  ? 387  PHE A O   1 
ATOM   3051 C  CB  . PHE A 1 388 ? 22.46  -5.263  -19.904 1    25.84  ? 387  PHE A CB  1 
ATOM   3052 C  CG  . PHE A 1 388 ? 22.41  -5.781  -18.482 1    26.71  ? 387  PHE A CG  1 
ATOM   3053 C  CD1 . PHE A 1 388 ? 23.127 -5.162  -17.47  1    26.74  ? 387  PHE A CD1 1 
ATOM   3054 C  CD2 . PHE A 1 388 ? 21.697 -6.93   -18.171 1    28.1   ? 387  PHE A CD2 1 
ATOM   3055 C  CE1 . PHE A 1 388 ? 23.11  -5.662  -16.172 1    28.3   ? 387  PHE A CE1 1 
ATOM   3056 C  CE2 . PHE A 1 388 ? 21.664 -7.416  -16.864 1    28.68  ? 387  PHE A CE2 1 
ATOM   3057 C  CZ  . PHE A 1 388 ? 22.396 -6.798  -15.877 1    28.32  ? 387  PHE A CZ  1 
ATOM   3058 N  N   . GLN A 1 389 ? 22.811 -2.806  -22.375 1    27.57  ? 388  GLN A N   1 
ATOM   3059 C  CA  . GLN A 1 389 ? 22.958 -2.704  -23.836 1    29.59  ? 388  GLN A CA  1 
ATOM   3060 C  C   . GLN A 1 389 ? 24.349 -2.292  -24.321 1    32.6   ? 388  GLN A C   1 
ATOM   3061 O  O   . GLN A 1 389 ? 24.897 -2.942  -25.211 1    33.2   ? 388  GLN A O   1 
ATOM   3062 C  CB  . GLN A 1 389 ? 21.887 -1.775  -24.466 1    28.84  ? 388  GLN A CB  1 
ATOM   3063 C  CG  . GLN A 1 389 ? 20.468 -2.285  -24.296 1    28.83  ? 388  GLN A CG  1 
ATOM   3064 C  CD  . GLN A 1 389 ? 20.313 -3.664  -24.9   1    31.23  ? 388  GLN A CD  1 
ATOM   3065 O  OE1 . GLN A 1 389 ? 20.601 -3.894  -26.079 1    32.44  ? 388  GLN A OE1 1 
ATOM   3066 N  NE2 . GLN A 1 389 ? 19.886 -4.596  -24.093 1    29.12  ? 388  GLN A NE2 1 
ATOM   3067 N  N   . GLU A 1 390 ? 24.911 -1.219  -23.759 1    33.87  ? 389  GLU A N   1 
ATOM   3068 C  CA  . GLU A 1 390 ? 26.214 -0.708  -24.232 1    35.07  ? 389  GLU A CA  1 
ATOM   3069 C  C   . GLU A 1 390 ? 27.379 -1.635  -23.915 1    34.24  ? 389  GLU A C   1 
ATOM   3070 O  O   . GLU A 1 390 ? 27.702 -1.852  -22.747 1    34.41  ? 389  GLU A O   1 
ATOM   3071 C  CB  . GLU A 1 390 ? 26.479 0.695   -23.664 1    38.62  ? 389  GLU A CB  1 
ATOM   3072 C  CG  . GLU A 1 390 ? 27.747 1.329   -24.203 1    47.41  ? 389  GLU A CG  1 
ATOM   3073 C  CD  . GLU A 1 390 ? 27.739 1.55    -25.702 1    58.72  ? 389  GLU A CD  1 
ATOM   3074 O  OE1 . GLU A 1 390 ? 26.664 1.901   -26.239 1    63.16  ? 389  GLU A OE1 1 
ATOM   3075 O  OE2 . GLU A 1 390 ? 28.802 1.369   -26.342 1    60.4   ? 389  GLU A OE2 1 
ATOM   3076 N  N   . PRO A 1 391 ? 28.029 -2.186  -24.945 1    34.35  ? 390  PRO A N   1 
ATOM   3077 C  CA  . PRO A 1 391 ? 29.114 -3.136  -24.686 1    34.4   ? 390  PRO A CA  1 
ATOM   3078 C  C   . PRO A 1 391 ? 30.256 -2.588  -23.835 1    35.19  ? 390  PRO A C   1 
ATOM   3079 O  O   . PRO A 1 391 ? 30.792 -1.516  -24.113 1    36.61  ? 390  PRO A O   1 
ATOM   3080 C  CB  . PRO A 1 391 ? 29.564 -3.566  -26.085 1    34.78  ? 390  PRO A CB  1 
ATOM   3081 C  CG  . PRO A 1 391 ? 28.449 -3.26   -26.969 1    34.89  ? 390  PRO A CG  1 
ATOM   3082 C  CD  . PRO A 1 391 ? 27.76  -2.062  -26.389 1    33.49  ? 390  PRO A CD  1 
ATOM   3083 N  N   . GLY A 1 392 ? 30.61  -3.34   -22.803 1    33.66  ? 391  GLY A N   1 
ATOM   3084 C  CA  . GLY A 1 392 ? 31.715 -3.038  -21.899 1    32.84  ? 391  GLY A CA  1 
ATOM   3085 C  C   . GLY A 1 392 ? 31.353 -2.387  -20.581 1    32.48  ? 391  GLY A C   1 
ATOM   3086 O  O   . GLY A 1 392 ? 32.092 -2.524  -19.607 1    32.3   ? 391  GLY A O   1 
ATOM   3087 N  N   . VAL A 1 393 ? 30.219 -1.693  -20.524 1    32.36  ? 392  VAL A N   1 
ATOM   3088 C  CA  . VAL A 1 393 ? 29.82  -0.977  -19.31  1    32.27  ? 392  VAL A CA  1 
ATOM   3089 C  C   . VAL A 1 393 ? 29.445 -1.906  -18.161 1    30.92  ? 392  VAL A C   1 
ATOM   3090 O  O   . VAL A 1 393 ? 30.101 -1.893  -17.113 1    31.02  ? 392  VAL A O   1 
ATOM   3091 C  CB  . VAL A 1 393 ? 28.705 0.037   -19.624 1    34.11  ? 392  VAL A CB  1 
ATOM   3092 C  CG1 . VAL A 1 393 ? 28.318 0.796   -18.362 1    34.78  ? 392  VAL A CG1 1 
ATOM   3093 C  CG2 . VAL A 1 393 ? 29.121 0.979   -20.761 1    35.72  ? 392  VAL A CG2 1 
ATOM   3094 N  N   . ALA A 1 394 ? 28.416 -2.762  -18.364 1    29.17  ? 393  ALA A N   1 
ATOM   3095 C  CA  . ALA A 1 394 ? 28.019 -3.69   -17.339 1    27.45  ? 393  ALA A CA  1 
ATOM   3096 C  C   . ALA A 1 394 ? 29.123 -4.726  -17.118 1    26.12  ? 393  ALA A C   1 
ATOM   3097 O  O   . ALA A 1 394 ? 29.329 -5.108  -15.971 1    27.43  ? 393  ALA A O   1 
ATOM   3098 C  CB  . ALA A 1 394 ? 26.692 -4.344  -17.694 1    27.74  ? 393  ALA A CB  1 
ATOM   3099 N  N   . GLU A 1 395 ? 29.913 -5.105  -18.155 1    25.18  ? 394  GLU A N   1 
ATOM   3100 C  CA  . GLU A 1 395 ? 31.007 -6.081  -17.924 1    25.96  ? 394  GLU A CA  1 
ATOM   3101 C  C   . GLU A 1 395 ? 31.995 -5.544  -16.891 1    27.08  ? 394  GLU A C   1 
ATOM   3102 O  O   . GLU A 1 395 ? 32.347 -6.256  -15.973 1    27.24  ? 394  GLU A O   1 
ATOM   3103 C  CB  . GLU A 1 395 ? 31.803 -6.4    -19.211 1    27.3   ? 394  GLU A CB  1 
ATOM   3104 C  CG  . GLU A 1 395 ? 31.081 -7.245  -20.234 1    27.27  ? 394  GLU A CG  1 
ATOM   3105 C  CD  . GLU A 1 395 ? 30.296 -6.496  -21.294 1    26.64  ? 394  GLU A CD  1 
ATOM   3106 O  OE1 . GLU A 1 395 ? 29.78  -5.39   -21.007 1    28.2   ? 394  GLU A OE1 1 
ATOM   3107 O  OE2 . GLU A 1 395 ? 30.197 -7.014  -22.429 1    27.72  ? 394  GLU A OE2 1 
ATOM   3108 N  N   . ALA A 1 396 ? 32.402 -4.272  -17.027 1    28.42  ? 395  ALA A N   1 
ATOM   3109 C  CA  . ALA A 1 396 ? 33.367 -3.687  -16.088 1    30.28  ? 395  ALA A CA  1 
ATOM   3110 C  C   . ALA A 1 396 ? 32.837 -3.653  -14.673 1    30.78  ? 395  ALA A C   1 
ATOM   3111 O  O   . ALA A 1 396 ? 33.555 -4.032  -13.745 1    31.34  ? 395  ALA A O   1 
ATOM   3112 C  CB  . ALA A 1 396 ? 33.771 -2.287  -16.549 1    30.47  ? 395  ALA A CB  1 
ATOM   3113 N  N   . GLU A 1 397 ? 31.559 -3.27   -14.489 1    30.32  ? 396  GLU A N   1 
ATOM   3114 C  CA  . GLU A 1 397 ? 30.981 -3.249  -13.153 1    30.1   ? 396  GLU A CA  1 
ATOM   3115 C  C   . GLU A 1 397 ? 30.865 -4.654  -12.57  1    29.68  ? 396  GLU A C   1 
ATOM   3116 O  O   . GLU A 1 397 ? 31.215 -4.865  -11.418 1    31.29  ? 396  GLU A O   1 
ATOM   3117 C  CB  . GLU A 1 397 ? 29.602 -2.559  -13.138 1    32.75  ? 396  GLU A CB  1 
ATOM   3118 C  CG  . GLU A 1 397 ? 29.089 -2.425  -11.714 1    37.23  ? 396  GLU A CG  1 
ATOM   3119 C  CD  . GLU A 1 397 ? 27.707 -1.834  -11.551 1    42.52  ? 396  GLU A CD  1 
ATOM   3120 O  OE1 . GLU A 1 397 ? 26.897 -1.946  -12.498 1    40.94  ? 396  GLU A OE1 1 
ATOM   3121 O  OE2 . GLU A 1 397 ? 27.423 -1.281  -10.463 1    42.43  ? 396  GLU A OE2 1 
ATOM   3122 N  N   . LEU A 1 398 ? 30.319 -5.612  -13.345 1    28.01  ? 397  LEU A N   1 
ATOM   3123 C  CA  . LEU A 1 398 ? 30.106 -6.961  -12.826 1    27.7   ? 397  LEU A CA  1 
ATOM   3124 C  C   . LEU A 1 398 ? 31.403 -7.734  -12.608 1    27.35  ? 397  LEU A C   1 
ATOM   3125 O  O   . LEU A 1 398 ? 31.445 -8.568  -11.723 1    27.67  ? 397  LEU A O   1 
ATOM   3126 C  CB  . LEU A 1 398 ? 29.145 -7.727  -13.755 1    28.34  ? 397  LEU A CB  1 
ATOM   3127 C  CG  . LEU A 1 398 ? 27.76  -7.125  -13.822 1    30.49  ? 397  LEU A CG  1 
ATOM   3128 C  CD1 . LEU A 1 398 ? 27.02  -7.606  -15.058 1    31.48  ? 397  LEU A CD1 1 
ATOM   3129 C  CD2 . LEU A 1 398 ? 26.97  -7.524  -12.601 1    32.8   ? 397  LEU A CD2 1 
ATOM   3130 N  N   . GLU A 1 399 ? 32.44  -7.475  -13.411 1    27.09  ? 398  GLU A N   1 
ATOM   3131 C  CA  . GLU A 1 399 ? 33.715 -8.186  -13.266 1    28.53  ? 398  GLU A CA  1 
ATOM   3132 C  C   . GLU A 1 399 ? 34.649 -7.544  -12.222 1    30.92  ? 398  GLU A C   1 
ATOM   3133 O  O   . GLU A 1 399 ? 35.625 -8.177  -11.838 1    31.42  ? 398  GLU A O   1 
ATOM   3134 C  CB  . GLU A 1 399 ? 34.47  -8.265  -14.602 1    29.38  ? 398  GLU A CB  1 
ATOM   3135 C  CG  . GLU A 1 399 ? 33.802 -9.185  -15.62  1    31.48  ? 398  GLU A CG  1 
ATOM   3136 C  CD  . GLU A 1 399 ? 34.259 -9.064  -17.068 1    33.82  ? 398  GLU A CD  1 
ATOM   3137 O  OE1 . GLU A 1 399 ? 35.316 -8.433  -17.32  1    34.31  ? 398  GLU A OE1 1 
ATOM   3138 O  OE2 . GLU A 1 399 ? 33.557 -9.601  -17.96  1    31.14  ? 398  GLU A OE2 1 
ATOM   3139 N  N   . GLN A 1 400 ? 34.378 -6.295  -11.799 1    31.47  ? 399  GLN A N   1 
ATOM   3140 C  CA  . GLN A 1 400 ? 35.278 -5.608  -10.865 1    32.48  ? 399  GLN A CA  1 
ATOM   3141 C  C   . GLN A 1 400 ? 35.574 -6.399  -9.565  1    32.21  ? 399  GLN A C   1 
ATOM   3142 O  O   . GLN A 1 400 ? 36.722 -6.435  -9.13   1    33.72  ? 399  GLN A O   1 
ATOM   3143 C  CB  . GLN A 1 400 ? 34.743 -4.213  -10.569 1    36.25  ? 399  GLN A CB  1 
ATOM   3144 C  CG  . GLN A 1 400 ? 35.795 -3.287  -9.998  1    43.81  ? 399  GLN A CG  1 
ATOM   3145 C  CD  . GLN A 1 400 ? 35.31  -2.688  -8.721  1    53.14  ? 399  GLN A CD  1 
ATOM   3146 O  OE1 . GLN A 1 400 ? 35.131 -1.466  -8.615  1    57.69  ? 399  GLN A OE1 1 
ATOM   3147 N  NE2 . GLN A 1 400 ? 35.062 -3.535  -7.73   1    53.13  ? 399  GLN A NE2 1 
ATOM   3148 N  N   . ASN A 1 401 ? 34.577 -7.056  -8.969  1    30.04  ? 400  ASN A N   1 
ATOM   3149 C  CA  . ASN A 1 401 ? 34.744 -7.823  -7.738  1    29.71  ? 400  ASN A CA  1 
ATOM   3150 C  C   . ASN A 1 401 ? 33.683 -8.907  -7.8    1    29.14  ? 400  ASN A C   1 
ATOM   3151 O  O   . ASN A 1 401 ? 32.52  -8.642  -7.504  1    29.04  ? 400  ASN A O   1 
ATOM   3152 C  CB  . ASN A 1 401 ? 34.498 -6.905  -6.535  1    30.63  ? 400  ASN A CB  1 
ATOM   3153 C  CG  . ASN A 1 401 ? 34.584 -7.556  -5.186  1    34.66  ? 400  ASN A CG  1 
ATOM   3154 O  OD1 . ASN A 1 401 ? 34.502 -8.773  -5.036  1    33.95  ? 400  ASN A OD1 1 
ATOM   3155 N  ND2 . ASN A 1 401 ? 34.718 -6.727  -4.14   1    37.53  ? 400  ASN A ND2 1 
ATOM   3156 N  N   . LEU A 1 402 ? 34.062 -10.099 -8.247  1    28.47  ? 401  LEU A N   1 
ATOM   3157 C  CA  . LEU A 1 402 ? 33.099 -11.173 -8.47   1    28.19  ? 401  LEU A CA  1 
ATOM   3158 C  C   . LEU A 1 402 ? 32.343 -11.603 -7.228  1    28.14  ? 401  LEU A C   1 
ATOM   3159 O  O   . LEU A 1 402 ? 31.135 -11.832 -7.292  1    29.15  ? 401  LEU A O   1 
ATOM   3160 C  CB  . LEU A 1 402 ? 33.821 -12.371 -9.137  1    28.04  ? 401  LEU A CB  1 
ATOM   3161 C  CG  . LEU A 1 402 ? 34.306 -12.099 -10.55  1    29.15  ? 401  LEU A CG  1 
ATOM   3162 C  CD1 . LEU A 1 402 ? 35.176 -13.245 -11.083 1    30.26  ? 401  LEU A CD1 1 
ATOM   3163 C  CD2 . LEU A 1 402 ? 33.15  -11.759 -11.485 1    29.22  ? 401  LEU A CD2 1 
ATOM   3164 N  N   . SER A 1 403 ? 33.012 -11.657 -6.072  1    27.91  ? 402  SER A N   1 
ATOM   3165 C  CA  . SER A 1 403 ? 32.353 -12.068 -4.837  1    28.95  ? 402  SER A CA  1 
ATOM   3166 C  C   . SER A 1 403 ? 31.252 -11.062 -4.492  1    28.61  ? 402  SER A C   1 
ATOM   3167 O  O   . SER A 1 403 ? 30.165 -11.461 -4.101  1    28.17  ? 402  SER A O   1 
ATOM   3168 C  CB  . SER A 1 403 ? 33.364 -12.16  -3.692  1    32.23  ? 402  SER A CB  1 
ATOM   3169 O  OG  . SER A 1 403 ? 32.664 -12.425 -2.488  1    37.78  ? 402  SER A OG  1 
ATOM   3170 N  N   . ARG A 1 404 ? 31.549 -9.757  -4.659  1    28.55  ? 403  ARG A N   1 
ATOM   3171 C  CA  . ARG A 1 404 ? 30.574 -8.706  -4.384  1    28.67  ? 403  ARG A CA  1 
ATOM   3172 C  C   . ARG A 1 404 ? 29.405 -8.826  -5.352  1    27.39  ? 403  ARG A C   1 
ATOM   3173 O  O   . ARG A 1 404 ? 28.256 -8.708  -4.924  1    27.24  ? 403  ARG A O   1 
ATOM   3174 C  CB  . ARG A 1 404 ? 31.22  -7.325  -4.511  1    30.88  ? 403  ARG A CB  1 
ATOM   3175 C  CG  . ARG A 1 404 ? 30.233 -6.188  -4.311  1    33.15  ? 403  ARG A CG  1 
ATOM   3176 C  CD  . ARG A 1 404 ? 30.915 -4.833  -4.449  1    35.78  ? 403  ARG A CD  1 
ATOM   3177 N  NE  . ARG A 1 404 ? 29.996 -3.75   -4.091  1    38.52  ? 403  ARG A NE  1 
ATOM   3178 C  CZ  . ARG A 1 404 ? 29.751 -2.689  -4.848  1    39.08  ? 403  ARG A CZ  1 
ATOM   3179 N  NH1 . ARG A 1 404 ? 30.374 -2.536  -6.009  1    37.85  ? 403  ARG A NH1 1 
ATOM   3180 N  NH2 . ARG A 1 404 ? 28.917 -1.747  -4.43   1    40.09  ? 403  ARG A NH2 1 
ATOM   3181 N  N   . THR A 1 405 ? 29.694 -9.109  -6.641  1    26.47  ? 404  THR A N   1 
ATOM   3182 C  CA  . THR A 1 405 ? 28.636 -9.281  -7.642  1    26.18  ? 404  THR A CA  1 
ATOM   3183 C  C   . THR A 1 405 ? 27.646 -10.392 -7.237  1    25.13  ? 404  THR A C   1 
ATOM   3184 O  O   . THR A 1 405 ? 26.438 -10.132 -7.151  1    24.76  ? 404  THR A O   1 
ATOM   3185 C  CB  . THR A 1 405 ? 29.249 -9.562  -9.026  1    26.47  ? 404  THR A CB  1 
ATOM   3186 O  OG1 . THR A 1 405 ? 29.908 -8.384  -9.514  1    28.78  ? 404  THR A OG1 1 
ATOM   3187 C  CG2 . THR A 1 405 ? 28.183 -10.031 -10.047 1    24.32  ? 404  THR A CG2 1 
ATOM   3188 N  N   . PHE A 1 406 ? 28.143 -11.616 -6.95   1    25.12  ? 405  PHE A N   1 
ATOM   3189 C  CA  . PHE A 1 406 ? 27.219 -12.721 -6.646  1    24.8   ? 405  PHE A CA  1 
ATOM   3190 C  C   . PHE A 1 406 ? 26.541 -12.556 -5.299  1    25.8   ? 405  PHE A C   1 
ATOM   3191 O  O   . PHE A 1 406 ? 25.351 -12.824 -5.181  1    25.93  ? 405  PHE A O   1 
ATOM   3192 C  CB  . PHE A 1 406 ? 27.901 -14.09  -6.8    1    24.74  ? 405  PHE A CB  1 
ATOM   3193 C  CG  . PHE A 1 406 ? 28.228 -14.303 -8.259  1    24.91  ? 405  PHE A CG  1 
ATOM   3194 C  CD1 . PHE A 1 406 ? 27.215 -14.431 -9.199  1    25.77  ? 405  PHE A CD1 1 
ATOM   3195 C  CD2 . PHE A 1 406 ? 29.535 -14.265 -8.706  1    25.53  ? 405  PHE A CD2 1 
ATOM   3196 C  CE1 . PHE A 1 406 ? 27.507 -14.525 -10.56  1    26.47  ? 405  PHE A CE1 1 
ATOM   3197 C  CE2 . PHE A 1 406 ? 29.829 -14.374 -10.059 1    26.57  ? 405  PHE A CE2 1 
ATOM   3198 C  CZ  . PHE A 1 406 ? 28.807 -14.508 -10.979 1    26.57  ? 405  PHE A CZ  1 
ATOM   3199 N  N   . LYS A 1 407 ? 27.279 -12.052 -4.299  1    25.65  ? 406  LYS A N   1 
ATOM   3200 C  CA  . LYS A 1 407 ? 26.651 -11.793 -2.997  1    26.13  ? 406  LYS A CA  1 
ATOM   3201 C  C   . LYS A 1 407 ? 25.595 -10.71  -3.098  1    25.94  ? 406  LYS A C   1 
ATOM   3202 O  O   . LYS A 1 407 ? 24.59  -10.806 -2.403  1    27     ? 406  LYS A O   1 
ATOM   3203 C  CB  . LYS A 1 407 ? 27.684 -11.441 -1.935  1    27.23  ? 406  LYS A CB  1 
ATOM   3204 C  CG  . LYS A 1 407 ? 28.453 -12.645 -1.472  1    29.24  ? 406  LYS A CG  1 
ATOM   3205 C  CD  . LYS A 1 407 ? 29.503 -12.215 -0.447  1    33.74  ? 406  LYS A CD  1 
ATOM   3206 C  CE  . LYS A 1 407 ? 30.372 -13.367 -0.046  1    37.57  ? 406  LYS A CE  1 
ATOM   3207 N  NZ  . LYS A 1 407 ? 31.233 -12.992 1.122   1    40.36  ? 406  LYS A NZ  1 
ATOM   3208 N  N   . SER A 1 408 ? 25.773 -9.718  -3.986  1    26.06  ? 407  SER A N   1 
ATOM   3209 C  CA  . SER A 1 408 ? 24.744 -8.673  -4.159  1    25.98  ? 407  SER A CA  1 
ATOM   3210 C  C   . SER A 1 408 ? 23.518 -9.199  -4.919  1    25.9   ? 407  SER A C   1 
ATOM   3211 O  O   . SER A 1 408 ? 22.383 -8.798  -4.64   1    25.32  ? 407  SER A O   1 
ATOM   3212 C  CB  . SER A 1 408 ? 25.307 -7.45   -4.885  1    28.01  ? 407  SER A CB  1 
ATOM   3213 O  OG  . SER A 1 408 ? 26.431 -6.898  -4.204  1    30.02  ? 407  SER A OG  1 
ATOM   3214 N  N   . LEU A 1 409 ? 23.753 -10.022 -5.954  1    25.44  ? 408  LEU A N   1 
ATOM   3215 C  CA  . LEU A 1 409 ? 22.658 -10.519 -6.794  1    25.32  ? 408  LEU A CA  1 
ATOM   3216 C  C   . LEU A 1 409 ? 21.811 -11.603 -6.13   1    26.21  ? 408  LEU A C   1 
ATOM   3217 O  O   . LEU A 1 409 ? 20.579 -11.544 -6.192  1    26.31  ? 408  LEU A O   1 
ATOM   3218 C  CB  . LEU A 1 409 ? 23.227 -11.065 -8.131  1    26.5   ? 408  LEU A CB  1 
ATOM   3219 C  CG  . LEU A 1 409 ? 23.741 -10.033 -9.113  1    28.31  ? 408  LEU A CG  1 
ATOM   3220 C  CD1 . LEU A 1 409 ? 24.545 -10.707 -10.257 1    29.43  ? 408  LEU A CD1 1 
ATOM   3221 C  CD2 . LEU A 1 409 ? 22.595 -9.225  -9.689  1    30.04  ? 408  LEU A CD2 1 
ATOM   3222 N  N   . PHE A 1 410 ? 22.463 -12.632 -5.561  1    26.34  ? 409  PHE A N   1 
ATOM   3223 C  CA  . PHE A 1 410 ? 21.783 -13.829 -5.038  1    26.84  ? 409  PHE A CA  1 
ATOM   3224 C  C   . PHE A 1 410 ? 21.263 -13.598 -3.642  1    28.76  ? 409  PHE A C   1 
ATOM   3225 O  O   . PHE A 1 410 ? 21.906 -13.998 -2.671  1    28.74  ? 409  PHE A O   1 
ATOM   3226 C  CB  . PHE A 1 410 ? 22.725 -15.064 -5.059  1    26.13  ? 409  PHE A CB  1 
ATOM   3227 C  CG  . PHE A 1 410 ? 23.254 -15.476 -6.428  1    26.33  ? 409  PHE A CG  1 
ATOM   3228 C  CD1 . PHE A 1 410 ? 22.615 -15.078 -7.588  1    27.4   ? 409  PHE A CD1 1 
ATOM   3229 C  CD2 . PHE A 1 410 ? 24.346 -16.328 -6.54   1    26.74  ? 409  PHE A CD2 1 
ATOM   3230 C  CE1 . PHE A 1 410 ? 23.116 -15.439 -8.844  1    27.8   ? 409  PHE A CE1 1 
ATOM   3231 C  CE2 . PHE A 1 410 ? 24.824 -16.714 -7.799  1    26.99  ? 409  PHE A CE2 1 
ATOM   3232 C  CZ  . PHE A 1 410 ? 24.193 -16.277 -8.936  1    26.31  ? 409  PHE A CZ  1 
ATOM   3233 N  N   . ARG A 1 411 ? 20.099 -12.965 -3.543  1    29.56  ? 410  ARG A N   1 
ATOM   3234 C  CA  . ARG A 1 411 ? 19.516 -12.651 -2.23   1    31.28  ? 410  ARG A CA  1 
ATOM   3235 C  C   . ARG A 1 411 ? 18.031 -13.003 -2.209  1    33.48  ? 410  ARG A C   1 
ATOM   3236 O  O   . ARG A 1 411 ? 17.357 -12.944 -3.241  1    34.52  ? 410  ARG A O   1 
ATOM   3237 C  CB  . ARG A 1 411 ? 19.713 -11.147 -1.915  1    31.6   ? 410  ARG A CB  1 
ATOM   3238 C  CG  . ARG A 1 411 ? 21.173 -10.705 -2.058  1    33.93  ? 410  ARG A CG  1 
ATOM   3239 C  CD  . ARG A 1 411 ? 21.468 -9.335  -1.499  1    37.13  ? 410  ARG A CD  1 
ATOM   3240 N  NE  . ARG A 1 411 ? 21.445 -9.343  -0.038  1    39.15  ? 410  ARG A NE  1 
ATOM   3241 C  CZ  . ARG A 1 411 ? 22.489 -9.623  0.728   1    41.06  ? 410  ARG A CZ  1 
ATOM   3242 N  NH1 . ARG A 1 411 ? 22.37  -9.608  2.052   1    40.4   ? 410  ARG A NH1 1 
ATOM   3243 N  NH2 . ARG A 1 411 ? 23.656 -9.949  0.181   1    39.29  ? 410  ARG A NH2 1 
ATOM   3244 N  N   . ALA A 1 412 ? 17.524 -13.411 -1.042  1    34.95  ? 411  ALA A N   1 
ATOM   3245 C  CA  . ALA A 1 412 ? 16.105 -13.711 -0.869  1    37.41  ? 411  ALA A CA  1 
ATOM   3246 C  C   . ALA A 1 412 ? 15.279 -12.393 -0.925  1    40.25  ? 411  ALA A C   1 
ATOM   3247 O  O   . ALA A 1 412 ? 15.859 -11.294 -0.948  1    40.92  ? 411  ALA A O   1 
ATOM   3248 C  CB  . ALA A 1 412 ? 15.883 -14.468 0.433   1    37.69  ? 411  ALA A CB  1 
ATOM   3249 N  N   . SER A 1 413 ? 13.952 -12.49  -1.054  1    42.19  ? 412  SER A N   1 
ATOM   3250 C  CA  . SER A 1 413 ? 13.107 -11.311 -1.252  1    45.12  ? 412  SER A CA  1 
ATOM   3251 C  C   . SER A 1 413 ? 13.19  -10.271 -0.135  1    48.06  ? 412  SER A C   1 
ATOM   3252 O  O   . SER A 1 413 ? 13.005 -9.079  -0.399  1    48.9   ? 412  SER A O   1 
ATOM   3253 C  CB  . SER A 1 413 ? 11.656 -11.706 -1.511  1    46.12  ? 412  SER A CB  1 
ATOM   3254 O  OG  . SER A 1 413 ? 11.113 -12.446 -0.432  1    48.55  ? 412  SER A OG  1 
ATOM   3255 N  N   . ASP A 1 414 ? 13.5   -10.701 1.084   1    49.75  ? 413  ASP A N   1 
ATOM   3256 C  CA  . ASP A 1 414 ? 13.603 -9.782  2.214   1    52.05  ? 413  ASP A CA  1 
ATOM   3257 C  C   . ASP A 1 414 ? 15.042 -9.346  2.532   1    53.06  ? 413  ASP A C   1 
ATOM   3258 O  O   . ASP A 1 414 ? 15.269 -8.776  3.605   1    53.47  ? 413  ASP A O   1 
ATOM   3259 C  CB  . ASP A 1 414 ? 12.923 -10.38  3.459   1    55.16  ? 413  ASP A CB  1 
ATOM   3260 C  CG  . ASP A 1 414 ? 13.442 -11.738 3.891   1    62.12  ? 413  ASP A CG  1 
ATOM   3261 O  OD1 . ASP A 1 414 ? 14.268 -12.323 3.156   1    63.32  ? 413  ASP A OD1 1 
ATOM   3262 O  OD2 . ASP A 1 414 ? 13.011 -12.225 4.963   1    65.24  ? 413  ASP A OD2 1 
ATOM   3263 N  N   . GLU A 1 415 ? 16.003 -9.577  1.606   1    52.55  ? 414  GLU A N   1 
ATOM   3264 C  CA  . GLU A 1 415 ? 17.411 -9.237  1.832   1    52.83  ? 414  GLU A CA  1 
ATOM   3265 C  C   . GLU A 1 415 ? 17.999 -8.279  0.786   1    55.42  ? 414  GLU A C   1 
ATOM   3266 O  O   . GLU A 1 415 ? 19.2   -8.036  0.827   1    55.61  ? 414  GLU A O   1 
ATOM   3267 C  CB  . GLU A 1 415 ? 18.28  -10.519 1.799   1    51.51  ? 414  GLU A CB  1 
ATOM   3268 C  CG  . GLU A 1 415 ? 17.845 -11.665 2.692   1    49.78  ? 414  GLU A CG  1 
ATOM   3269 C  CD  . GLU A 1 415 ? 18.667 -12.928 2.504   1    48.61  ? 414  GLU A CD  1 
ATOM   3270 O  OE1 . GLU A 1 415 ? 19.004 -13.25  1.338   1    43.81  ? 414  GLU A OE1 1 
ATOM   3271 O  OE2 . GLU A 1 415 ? 18.968 -13.606 3.514   1    48.95  ? 414  GLU A OE2 1 
ATOM   3272 N  N   . SER A 1 416 ? 17.205 -7.785  -0.173  1    57     ? 415  SER A N   1 
ATOM   3273 C  CA  . SER A 1 416 ? 17.731 -6.957  -1.261  1    58.91  ? 415  SER A CA  1 
ATOM   3274 C  C   . SER A 1 416 ? 18.644 -5.781  -0.883  1    60.94  ? 415  SER A C   1 
ATOM   3275 O  O   . SER A 1 416 ? 18.445 -5.077  0.109   1    61.26  ? 415  SER A O   1 
ATOM   3276 C  CB  . SER A 1 416 ? 16.604 -6.421  -2.139  1    60.6   ? 415  SER A CB  1 
ATOM   3277 O  OG  . SER A 1 416 ? 17.084 -5.553  -3.159  1    63.26  ? 415  SER A OG  1 
ATOM   3278 N  N   . VAL A 1 417 ? 19.636 -5.575  -1.749  1    62.07  ? 416  VAL A N   1 
ATOM   3279 C  CA  . VAL A 1 417 ? 20.559 -4.445  -1.798  1    63.63  ? 416  VAL A CA  1 
ATOM   3280 C  C   . VAL A 1 417 ? 20.503 -3.783  -3.215  1    65.3   ? 416  VAL A C   1 
ATOM   3281 O  O   . VAL A 1 417 ? 21.008 -2.67   -3.368  1    65.74  ? 416  VAL A O   1 
ATOM   3282 C  CB  . VAL A 1 417 ? 22.012 -4.759  -1.327  1    64.23  ? 416  VAL A CB  1 
ATOM   3283 C  CG1 . VAL A 1 417 ? 22.039 -5.265  0.117   1    64.52  ? 416  VAL A CG1 1 
ATOM   3284 C  CG2 . VAL A 1 417 ? 22.709 -5.74   -2.263  1    64.53  ? 416  VAL A CG2 1 
ATOM   3285 N  N   . LEU A 1 418 ? 19.85  -4.454  -4.233  1    66.08  ? 417  LEU A N   1 
ATOM   3286 C  CA  . LEU A 1 418 ? 19.694 -3.99   -5.625  1    66.94  ? 417  LEU A CA  1 
ATOM   3287 C  C   . LEU A 1 418 ? 18.235 -3.888  -6.081  1    67.8   ? 417  LEU A C   1 
ATOM   3288 O  O   . LEU A 1 418 ? 17.533 -4.901  -6.133  1    68.09  ? 417  LEU A O   1 
ATOM   3289 C  CB  . LEU A 1 418 ? 20.371 -4.932  -6.638  1    66.89  ? 417  LEU A CB  1 
ATOM   3290 C  CG  . LEU A 1 418 ? 21.68  -5.572  -6.282  1    68.24  ? 417  LEU A CG  1 
ATOM   3291 C  CD1 . LEU A 1 418 ? 22.111 -6.527  -7.358  1    68.5   ? 417  LEU A CD1 1 
ATOM   3292 C  CD2 . LEU A 1 418 ? 22.713 -4.556  -6.032  1    68.79  ? 417  LEU A CD2 1 
ATOM   3293 N  N   . SER A 1 419 ? 17.828 -2.705  -6.539  1    67.91  ? 418  SER A N   1 
ATOM   3294 C  CA  . SER A 1 419 ? 16.51  -2.503  -7.131  1    68.48  ? 418  SER A CA  1 
ATOM   3295 C  C   . SER A 1 419 ? 16.747 -2.454  -8.651  1    68.6   ? 418  SER A C   1 
ATOM   3296 O  O   . SER A 1 419 ? 17.587 -1.679  -9.105  1    68.98  ? 418  SER A O   1 
ATOM   3297 C  CB  . SER A 1 419 ? 15.902 -1.19   -6.645  1    70.13  ? 418  SER A CB  1 
ATOM   3298 O  OG  . SER A 1 419 ? 16.697 -0.08   -7.03   1    72.62  ? 418  SER A OG  1 
ATOM   3299 N  N   . MET A 1 420 ? 16.039 -3.284  -9.437  1    68.09  ? 419  MET A N   1 
ATOM   3300 C  CA  . MET A 1 420 ? 16.234 -3.353  -10.892 1    67.87  ? 419  MET A CA  1 
ATOM   3301 C  C   . MET A 1 420 ? 15.701 -2.145  -11.686 1    67.58  ? 419  MET A C   1 
ATOM   3302 O  O   . MET A 1 420 ? 15.737 -2.153  -12.922 1    67.42  ? 419  MET A O   1 
ATOM   3303 C  CB  . MET A 1 420 ? 15.661 -4.66   -11.462 1    68.34  ? 419  MET A CB  1 
ATOM   3304 C  CG  . MET A 1 420 ? 16.373 -5.903  -10.954 1    70.52  ? 419  MET A CG  1 
ATOM   3305 S  SD  . MET A 1 420 ? 18.127 -5.955  -11.397 1    75.26  ? 419  MET A SD  1 
ATOM   3306 C  CE  . MET A 1 420 ? 18.626 -7.458  -10.562 1    74.26  ? 419  MET A CE  1 
ATOM   3307 N  N   . HIS A 1 421 ? 15.229 -1.109  -10.989 1    67.04  ? 420  HIS A N   1 
ATOM   3308 C  CA  . HIS A 1 421 ? 14.75  0.111   -11.638 1    66.84  ? 420  HIS A CA  1 
ATOM   3309 C  C   . HIS A 1 421 ? 15.726 1.274   -11.37  1    65.06  ? 420  HIS A C   1 
ATOM   3310 O  O   . HIS A 1 421 ? 16.511 1.211   -10.42  1    65.45  ? 420  HIS A O   1 
ATOM   3311 C  CB  . HIS A 1 421 ? 13.319 0.455   -11.176 1    68.64  ? 420  HIS A CB  1 
ATOM   3312 C  CG  . HIS A 1 421 ? 13.22  0.873   -9.741  1    72.17  ? 420  HIS A CG  1 
ATOM   3313 N  ND1 . HIS A 1 421 ? 12.991 -0.051  -8.736  1    74.24  ? 420  HIS A ND1 1 
ATOM   3314 C  CD2 . HIS A 1 421 ? 13.293 2.11    -9.192  1    73.62  ? 420  HIS A CD2 1 
ATOM   3315 C  CE1 . HIS A 1 421 ? 12.943 0.649   -7.611  1    74.97  ? 420  HIS A CE1 1 
ATOM   3316 N  NE2 . HIS A 1 421 ? 13.124 1.952   -7.836  1    74.92  ? 420  HIS A NE2 1 
ATOM   3317 N  N   . LYS A 1 422 ? 15.701 2.31    -12.227 1    63     ? 421  LYS A N   1 
ATOM   3318 C  CA  . LYS A 1 422 ? 16.569 3.491   -12.125 1    61.43  ? 421  LYS A CA  1 
ATOM   3319 C  C   . LYS A 1 422 ? 18.072 3.177   -12.163 1    59.62  ? 421  LYS A C   1 
ATOM   3320 O  O   . LYS A 1 422 ? 18.857 3.901   -11.563 1    59.67  ? 421  LYS A O   1 
ATOM   3321 C  CB  . LYS A 1 422 ? 16.226 4.322   -10.875 1    63.3   ? 421  LYS A CB  1 
ATOM   3322 C  CG  . LYS A 1 422 ? 14.814 4.902   -10.88  1    66.66  ? 421  LYS A CG  1 
ATOM   3323 C  CD  . LYS A 1 422 ? 14.611 5.921   -11.992 1    69.97  ? 421  LYS A CD  1 
ATOM   3324 C  CE  . LYS A 1 422 ? 13.352 6.725   -11.775 1    73.24  ? 421  LYS A CE  1 
ATOM   3325 N  NZ  . LYS A 1 422 ? 13.34  7.378   -10.439 1    75.11  ? 421  LYS A NZ  1 
ATOM   3326 N  N   . VAL A 1 423 ? 18.47  2.106   -12.868 1    57.68  ? 422  VAL A N   1 
ATOM   3327 C  CA  . VAL A 1 423 ? 19.862 1.68    -12.963 1    56.28  ? 422  VAL A CA  1 
ATOM   3328 C  C   . VAL A 1 423 ? 20.719 2.598   -13.842 1    55.06  ? 422  VAL A C   1 
ATOM   3329 O  O   . VAL A 1 423 ? 21.844 2.928   -13.471 1    54.82  ? 422  VAL A O   1 
ATOM   3330 C  CB  . VAL A 1 423 ? 19.95  0.207   -13.416 1    56.62  ? 422  VAL A CB  1 
ATOM   3331 C  CG1 . VAL A 1 423 ? 21.398 -0.236  -13.542 1    57.37  ? 422  VAL A CG1 1 
ATOM   3332 C  CG2 . VAL A 1 423 ? 19.185 -0.703  -12.459 1    56.84  ? 422  VAL A CG2 1 
ATOM   3333 N  N   . CYS A 1 424 ? 20.191 3.012   -14.997 1    54.15  ? 423  CYS A N   1 
ATOM   3334 C  CA  . CYS A 1 424 ? 20.92  3.889   -15.907 1    54.22  ? 423  CYS A CA  1 
ATOM   3335 C  C   . CYS A 1 424 ? 21.171 5.252   -15.266 1    54     ? 423  CYS A C   1 
ATOM   3336 O  O   . CYS A 1 424 ? 22.279 5.777   -15.359 1    54.13  ? 423  CYS A O   1 
ATOM   3337 C  CB  . CYS A 1 424 ? 20.179 4.03    -17.235 1    55.1   ? 423  CYS A CB  1 
ATOM   3338 S  SG  . CYS A 1 424 ? 19.868 2.46    -18.084 1    58.05  ? 423  CYS A SG  1 
ATOM   3339 N  N   A GLU A 1 425 ? 20.143 5.819   -14.617 0.5  53.8   ? 424  GLU A N   1 
ATOM   3340 N  N   B GLU A 1 425 ? 20.143 5.819   -14.617 0.5  53.8   ? 424  GLU A N   1 
ATOM   3341 C  CA  A GLU A 1 425 ? 20.23  7.116   -13.951 0.5  54.05  ? 424  GLU A CA  1 
ATOM   3342 C  CA  B GLU A 1 425 ? 20.23  7.116   -13.951 0.5  54.05  ? 424  GLU A CA  1 
ATOM   3343 C  C   A GLU A 1 425 ? 21.181 7.064   -12.754 0.5  54.08  ? 424  GLU A C   1 
ATOM   3344 C  C   B GLU A 1 425 ? 21.181 7.064   -12.754 0.5  54.08  ? 424  GLU A C   1 
ATOM   3345 O  O   A GLU A 1 425 ? 21.897 8.032   -12.497 0.5  54.33  ? 424  GLU A O   1 
ATOM   3346 O  O   B GLU A 1 425 ? 21.897 8.032   -12.497 0.5  54.33  ? 424  GLU A O   1 
ATOM   3347 C  CB  A GLU A 1 425 ? 18.838 7.59    -13.511 0.5  56.12  ? 424  GLU A CB  1 
ATOM   3348 C  CB  B GLU A 1 425 ? 18.838 7.59    -13.511 0.5  56.12  ? 424  GLU A CB  1 
ATOM   3349 N  N   . ALA A 1 426 ? 21.207 5.931   -12.037 1    53.58  ? 425  ALA A N   1 
ATOM   3350 C  CA  . ALA A 1 426 ? 22.095 5.759   -10.891 1    53.38  ? 425  ALA A CA  1 
ATOM   3351 C  C   . ALA A 1 426 ? 23.558 5.627   -11.323 1    52.86  ? 425  ALA A C   1 
ATOM   3352 O  O   . ALA A 1 426 ? 24.446 6.112   -10.63  1    53.13  ? 425  ALA A O   1 
ATOM   3353 C  CB  . ALA A 1 426 ? 21.681 4.54    -10.088 1    53.71  ? 425  ALA A CB  1 
ATOM   3354 N  N   . GLY A 1 427 ? 23.792 5.001   -12.474 1    52.07  ? 426  GLY A N   1 
ATOM   3355 C  CA  . GLY A 1 427 ? 25.138 4.79    -12.998 1    51.65  ? 426  GLY A CA  1 
ATOM   3356 C  C   . GLY A 1 427 ? 25.621 3.348   -12.945 1    50.76  ? 426  GLY A C   1 
ATOM   3357 O  O   . GLY A 1 427 ? 26.725 3.044   -13.399 1    51.19  ? 426  GLY A O   1 
ATOM   3358 N  N   . GLY A 1 428 ? 24.796 2.457   -12.41  1    49.36  ? 427  GLY A N   1 
ATOM   3359 C  CA  . GLY A 1 428 ? 25.121 1.042   -12.313 1    48.46  ? 427  GLY A CA  1 
ATOM   3360 C  C   . GLY A 1 428 ? 24.225 0.292   -11.357 1    47.04  ? 427  GLY A C   1 
ATOM   3361 O  O   . GLY A 1 428 ? 23.456 0.897   -10.603 1    47.25  ? 427  GLY A O   1 
ATOM   3362 N  N   . LEU A 1 429 ? 24.314 -1.035  -11.386 1    45.59  ? 428  LEU A N   1 
ATOM   3363 C  CA  . LEU A 1 429 ? 23.544 -1.917  -10.513 1    44.99  ? 428  LEU A CA  1 
ATOM   3364 C  C   . LEU A 1 429 ? 23.914 -1.787  -9.036  1    43.42  ? 428  LEU A C   1 
ATOM   3365 O  O   . LEU A 1 429 ? 23.042 -1.927  -8.183  1    43.34  ? 428  LEU A O   1 
ATOM   3366 C  CB  . LEU A 1 429 ? 23.789 -3.384  -10.909 1    45.74  ? 428  LEU A CB  1 
ATOM   3367 C  CG  . LEU A 1 429 ? 22.936 -3.959  -12.026 1    47.83  ? 428  LEU A CG  1 
ATOM   3368 C  CD1 . LEU A 1 429 ? 23.296 -5.435  -12.261 1    48.67  ? 428  LEU A CD1 1 
ATOM   3369 C  CD2 . LEU A 1 429 ? 21.463 -3.849  -11.69  1    48.14  ? 428  LEU A CD2 1 
ATOM   3370 N  N   . PHE A 1 430 ? 25.205 -1.601  -8.735  1    42.44  ? 429  PHE A N   1 
ATOM   3371 C  CA  . PHE A 1 430 ? 25.7   -1.622  -7.358  1    43.19  ? 429  PHE A CA  1 
ATOM   3372 C  C   . PHE A 1 430 ? 26.084 -0.279  -6.742  1    44.98  ? 429  PHE A C   1 
ATOM   3373 O  O   . PHE A 1 430 ? 26.711 -0.286  -5.683  1    45.29  ? 429  PHE A O   1 
ATOM   3374 C  CB  . PHE A 1 430 ? 26.913 -2.571  -7.238  1    42.48  ? 429  PHE A CB  1 
ATOM   3375 C  CG  . PHE A 1 430 ? 26.775 -3.938  -7.872  1    42.55  ? 429  PHE A CG  1 
ATOM   3376 C  CD1 . PHE A 1 430 ? 25.648 -4.71   -7.657  1    43.02  ? 429  PHE A CD1 1 
ATOM   3377 C  CD2 . PHE A 1 430 ? 27.799 -4.471  -8.633  1    43.01  ? 429  PHE A CD2 1 
ATOM   3378 C  CE1 . PHE A 1 430 ? 25.526 -5.972  -8.227  1    43.09  ? 429  PHE A CE1 1 
ATOM   3379 C  CE2 . PHE A 1 430 ? 27.68  -5.733  -9.196  1    43.52  ? 429  PHE A CE2 1 
ATOM   3380 C  CZ  . PHE A 1 430 ? 26.536 -6.469  -9.003  1    43.24  ? 429  PHE A CZ  1 
ATOM   3381 N  N   . VAL A 1 431 ? 25.742 0.851   -7.367  1    45.9   ? 430  VAL A N   1 
ATOM   3382 C  CA  . VAL A 1 431 ? 26.149 2.165   -6.849  1    47.54  ? 430  VAL A CA  1 
ATOM   3383 C  C   . VAL A 1 431 ? 25.596 2.498   -5.447  1    47.9   ? 430  VAL A C   1 
ATOM   3384 O  O   . VAL A 1 431 ? 26.254 3.223   -4.703  1    48.13  ? 430  VAL A O   1 
ATOM   3385 C  CB  . VAL A 1 431 ? 25.851 3.302   -7.839  1    48.97  ? 430  VAL A CB  1 
ATOM   3386 C  CG1 . VAL A 1 431 ? 26.588 3.081   -9.155  1    50.13  ? 430  VAL A CG1 1 
ATOM   3387 C  CG2 . VAL A 1 431 ? 24.353 3.439   -8.065  1    49.44  ? 430  VAL A CG2 1 
ATOM   3388 N  N   . ASN A 1 432 ? 24.423 1.967   -5.08   1    47.72  ? 431  ASN A N   1 
ATOM   3389 C  CA  . ASN A 1 432 ? 23.882 2.187   -3.735  1    48.06  ? 431  ASN A CA  1 
ATOM   3390 C  C   . ASN A 1 432 ? 23.988 0.92    -2.877  1    45.57  ? 431  ASN A C   1 
ATOM   3391 O  O   . ASN A 1 432 ? 23.2   0.748   -1.946  1    46.16  ? 431  ASN A O   1 
ATOM   3392 C  CB  . ASN A 1 432 ? 22.426 2.647   -3.805  1    51.48  ? 431  ASN A CB  1 
ATOM   3393 C  CG  . ASN A 1 432 ? 22.273 4.079   -4.253  1    57.6   ? 431  ASN A CG  1 
ATOM   3394 O  OD1 . ASN A 1 432 ? 22.825 5.008   -3.645  1    59.91  ? 431  ASN A OD1 1 
ATOM   3395 N  ND2 . ASN A 1 432 ? 21.509 4.294   -5.329  1    58.82  ? 431  ASN A ND2 1 
ATOM   3396 N  N   . SER A 1 433 ? 24.958 0.034   -3.193  1    42.27  ? 432  SER A N   1 
ATOM   3397 C  CA  . SER A 1 433 ? 25.141 -1.243  -2.531  1    39.57  ? 432  SER A CA  1 
ATOM   3398 C  C   . SER A 1 433 ? 26.449 -1.291  -1.751  1    36.21  ? 432  SER A C   1 
ATOM   3399 O  O   . SER A 1 433 ? 27.431 -0.668  -2.149  1    34.37  ? 432  SER A O   1 
ATOM   3400 C  CB  . SER A 1 433 ? 25.126 -2.367  -3.57   1    41.58  ? 432  SER A CB  1 
ATOM   3401 O  OG  . SER A 1 433 ? 23.97  -2.276  -4.379  1    44.94  ? 432  SER A OG  1 
ATOM   3402 N  N   . PRO A 1 434 ? 26.48  -2.067  -0.663  1    35.55  ? 433  PRO A N   1 
ATOM   3403 C  CA  . PRO A 1 434 ? 27.702 -2.143  0.145   1    35.85  ? 433  PRO A CA  1 
ATOM   3404 C  C   . PRO A 1 434 ? 28.86  -2.795  -0.58   1    36.78  ? 433  PRO A C   1 
ATOM   3405 O  O   . PRO A 1 434 ? 28.64  -3.596  -1.499  1    35.74  ? 433  PRO A O   1 
ATOM   3406 C  CB  . PRO A 1 434 ? 27.292 -3.004  1.343   1    36.21  ? 433  PRO A CB  1 
ATOM   3407 C  CG  . PRO A 1 434 ? 26.111 -3.766  0.882   1    36.3   ? 433  PRO A CG  1 
ATOM   3408 C  CD  . PRO A 1 434 ? 25.393 -2.87   -0.074  1    34.96  ? 433  PRO A CD  1 
ATOM   3409 N  N   . GLU A 1 435 ? 30.085 -2.455  -0.168  1    37.63  ? 434  GLU A N   1 
ATOM   3410 C  CA  . GLU A 1 435 ? 31.29  -3.048  -0.755  1    39.38  ? 434  GLU A CA  1 
ATOM   3411 C  C   . GLU A 1 435 ? 31.45  -4.497  -0.367  1    39.73  ? 434  GLU A C   1 
ATOM   3412 O  O   . GLU A 1 435 ? 31.944 -5.303  -1.167  1    39.89  ? 434  GLU A O   1 
ATOM   3413 C  CB  . GLU A 1 435 ? 32.555 -2.286  -0.348  1    43.47  ? 434  GLU A CB  1 
ATOM   3414 C  CG  . GLU A 1 435 ? 32.937 -1.204  -1.337  1    52.74  ? 434  GLU A CG  1 
ATOM   3415 C  CD  . GLU A 1 435 ? 33.142 -1.687  -2.757  1    62.74  ? 434  GLU A CD  1 
ATOM   3416 O  OE1 . GLU A 1 435 ? 33.724 -2.784  -2.93   1    64.29  ? 434  GLU A OE1 1 
ATOM   3417 O  OE2 . GLU A 1 435 ? 32.72  -0.968  -3.693  1    65.95  ? 434  GLU A OE2 1 
ATOM   3418 N  N   . GLU A 1 436 ? 31.083 -4.827  0.873   1    39.46  ? 435  GLU A N   1 
ATOM   3419 C  CA  . GLU A 1 436 ? 31.148 -6.172  1.4     1    40.39  ? 435  GLU A CA  1 
ATOM   3420 C  C   . GLU A 1 436 ? 29.759 -6.564  1.852   1    40.14  ? 435  GLU A C   1 
ATOM   3421 O  O   . GLU A 1 436 ? 29.432 -6.458  3.035   1    40.22  ? 435  GLU A O   1 
ATOM   3422 C  CB  . GLU A 1 436 ? 32.138 -6.263  2.573   1    44.93  ? 435  GLU A CB  1 
ATOM   3423 C  CG  . GLU A 1 436 ? 33.577 -6.004  2.165   1    53.63  ? 435  GLU A CG  1 
ATOM   3424 C  CD  . GLU A 1 436 ? 34.606 -6.403  3.206   1    64.14  ? 435  GLU A CD  1 
ATOM   3425 O  OE1 . GLU A 1 436 ? 35.747 -5.889  3.135   1    66.33  ? 435  GLU A OE1 1 
ATOM   3426 O  OE2 . GLU A 1 436 ? 34.276 -7.226  4.09    1    67.67  ? 435  GLU A OE2 1 
ATOM   3427 N  N   . PRO A 1 437 ? 28.917 -7.03   0.918   1    39.62  ? 436  PRO A N   1 
ATOM   3428 C  CA  . PRO A 1 437 ? 27.556 -7.41   1.305   1    39.12  ? 436  PRO A CA  1 
ATOM   3429 C  C   . PRO A 1 437 ? 27.523 -8.603  2.249   1    38.88  ? 436  PRO A C   1 
ATOM   3430 O  O   . PRO A 1 437 ? 28.447 -9.431  2.271   1    38.8   ? 436  PRO A O   1 
ATOM   3431 C  CB  . PRO A 1 437 ? 26.862 -7.719  -0.029  1    39.7   ? 436  PRO A CB  1 
ATOM   3432 C  CG  . PRO A 1 437 ? 27.929 -7.871  -1.005  1    40.39  ? 436  PRO A CG  1 
ATOM   3433 C  CD  . PRO A 1 437 ? 29.155 -7.193  -0.53   1    39.15  ? 436  PRO A CD  1 
ATOM   3434 N  N   . SER A 1 438 ? 26.457 -8.688  3.042   1    38.59  ? 437  SER A N   1 
ATOM   3435 C  CA  . SER A 1 438 ? 26.276 -9.809  3.943   1    40.08  ? 437  SER A CA  1 
ATOM   3436 C  C   . SER A 1 438 ? 25.916 -11.064 3.113   1    41.37  ? 437  SER A C   1 
ATOM   3437 O  O   . SER A 1 438 ? 25.407 -10.954 2.001   1    41.84  ? 437  SER A O   1 
ATOM   3438 C  CB  . SER A 1 438 ? 25.163 -9.511  4.94    1    42.09  ? 437  SER A CB  1 
ATOM   3439 O  OG  . SER A 1 438 ? 23.942 -9.265  4.259   1    45.01  ? 437  SER A OG  1 
ATOM   3440 N  N   . LEU A 1 439 ? 26.21  -12.243 3.645   1    41.33  ? 438  LEU A N   1 
ATOM   3441 C  CA  . LEU A 1 439 ? 25.917 -13.489 2.954   1    41.8   ? 438  LEU A CA  1 
ATOM   3442 C  C   . LEU A 1 439 ? 24.417 -13.778 3.084   1    41.19  ? 438  LEU A C   1 
ATOM   3443 O  O   . LEU A 1 439 ? 23.852 -13.669 4.167   1    41.18  ? 438  LEU A O   1 
ATOM   3444 C  CB  . LEU A 1 439 ? 26.768 -14.59  3.595   1    42.57  ? 438  LEU A CB  1 
ATOM   3445 C  CG  . LEU A 1 439 ? 26.835 -15.923 2.912   1    44.36  ? 438  LEU A CG  1 
ATOM   3446 C  CD1 . LEU A 1 439 ? 27.339 -15.795 1.461   1    43.94  ? 438  LEU A CD1 1 
ATOM   3447 C  CD2 . LEU A 1 439 ? 27.695 -16.85  3.722   1    45.11  ? 438  LEU A CD2 1 
ATOM   3448 N  N   . SER A 1 440 ? 23.756 -14.048 1.961   1    40.43  ? 439  SER A N   1 
ATOM   3449 C  CA  . SER A 1 440 ? 22.338 -14.375 1.97    1    39.96  ? 439  SER A CA  1 
ATOM   3450 C  C   . SER A 1 440 ? 22.12  -15.716 2.679   1    40.77  ? 439  SER A C   1 
ATOM   3451 O  O   . SER A 1 440 ? 22.99  -16.581 2.627   1    40.74  ? 439  SER A O   1 
ATOM   3452 C  CB  . SER A 1 440 ? 21.831 -14.486 0.535   1    39.35  ? 439  SER A CB  1 
ATOM   3453 O  OG  . SER A 1 440 ? 20.585 -15.154 0.446   1    38.99  ? 439  SER A OG  1 
ATOM   3454 N  N   . ARG A 1 441 ? 20.931 -15.922 3.262   1    41.01  ? 440  ARG A N   1 
ATOM   3455 C  CA  . ARG A 1 441 ? 20.58  -17.22  3.855   1    41.7   ? 440  ARG A CA  1 
ATOM   3456 C  C   . ARG A 1 441 ? 20.475 -18.335 2.778   1    40.53  ? 440  ARG A C   1 
ATOM   3457 O  O   . ARG A 1 441 ? 20.501 -19.515 3.115   1    40.89  ? 440  ARG A O   1 
ATOM   3458 C  CB  . ARG A 1 441 ? 19.238 -17.111 4.601   1    44.9   ? 440  ARG A CB  1 
ATOM   3459 C  CG  . ARG A 1 441 ? 18.027 -16.927 3.684   1    51.18  ? 440  ARG A CG  1 
ATOM   3460 C  CD  . ARG A 1 441 ? 16.737 -17.198 4.441   1    57.51  ? 440  ARG A CD  1 
ATOM   3461 N  NE  . ARG A 1 441 ? 15.537 -16.789 3.705   1    62.68  ? 440  ARG A NE  1 
ATOM   3462 C  CZ  . ARG A 1 441 ? 14.996 -15.574 3.769   1    66.28  ? 440  ARG A CZ  1 
ATOM   3463 N  NH1 . ARG A 1 441 ? 13.888 -15.298 3.091   1    66.42  ? 440  ARG A NH1 1 
ATOM   3464 N  NH2 . ARG A 1 441 ? 15.567 -14.621 4.499   1    66.88  ? 440  ARG A NH2 1 
ATOM   3465 N  N   . MET A 1 442 ? 20.355 -17.968 1.485   1    38.65  ? 441  MET A N   1 
ATOM   3466 C  CA  . MET A 1 442 ? 20.235 -18.952 0.414   1    37.6   ? 441  MET A CA  1 
ATOM   3467 C  C   . MET A 1 442 ? 21.542 -19.57  0.022   1    37.51  ? 441  MET A C   1 
ATOM   3468 O  O   . MET A 1 442 ? 21.527 -20.646 -0.563  1    37.86  ? 441  MET A O   1 
ATOM   3469 C  CB  . MET A 1 442 ? 19.673 -18.306 -0.854  1    37.52  ? 441  MET A CB  1 
ATOM   3470 C  CG  . MET A 1 442 ? 18.332 -17.711 -0.699  1    38.83  ? 441  MET A CG  1 
ATOM   3471 S  SD  . MET A 1 442 ? 17.627 -17.292 -2.324  1    33.78  ? 441  MET A SD  1 
ATOM   3472 C  CE  . MET A 1 442 ? 18.907 -16.258 -2.994  1    31.04  ? 441  MET A CE  1 
ATOM   3473 N  N   . VAL A 1 443 ? 22.672 -18.855 0.218   1    36.94  ? 442  VAL A N   1 
ATOM   3474 C  CA  . VAL A 1 443 ? 23.973 -19.323 -0.24   1    37.04  ? 442  VAL A CA  1 
ATOM   3475 C  C   . VAL A 1 443 ? 25.036 -19.331 0.85    1    37.31  ? 442  VAL A C   1 
ATOM   3476 O  O   . VAL A 1 443 ? 25.053 -18.45  1.716   1    38.86  ? 442  VAL A O   1 
ATOM   3477 C  CB  . VAL A 1 443 ? 24.472 -18.474 -1.441  1    38.39  ? 442  VAL A CB  1 
ATOM   3478 C  CG1 . VAL A 1 443 ? 23.74  -18.82  -2.719  1    39.33  ? 442  VAL A CG1 1 
ATOM   3479 C  CG2 . VAL A 1 443 ? 24.395 -16.976 -1.155  1    39.17  ? 442  VAL A CG2 1 
ATOM   3480 N  N   . THR A 1 444 ? 25.938 -20.308 0.797   1    35.11  ? 443  THR A N   1 
ATOM   3481 C  CA  . THR A 1 444 ? 27.084 -20.336 1.691   1    33.94  ? 443  THR A CA  1 
ATOM   3482 C  C   . THR A 1 444 ? 28.243 -19.587 1.012   1    32.48  ? 443  THR A C   1 
ATOM   3483 O  O   . THR A 1 444 ? 28.195 -19.331 -0.201  1    32.01  ? 443  THR A O   1 
ATOM   3484 C  CB  . THR A 1 444 ? 27.501 -21.786 2.016   1    35.24  ? 443  THR A CB  1 
ATOM   3485 O  OG1 . THR A 1 444 ? 27.98  -22.425 0.816   1    35.12  ? 443  THR A OG1 1 
ATOM   3486 C  CG2 . THR A 1 444 ? 26.378 -22.589 2.652   1    36.19  ? 443  THR A CG2 1 
ATOM   3487 N  N   . GLU A 1 445 ? 29.325 -19.275 1.769   1    31.14  ? 444  GLU A N   1 
ATOM   3488 C  CA  . GLU A 1 445 ? 30.501 -18.654 1.193   1    31.36  ? 444  GLU A CA  1 
ATOM   3489 C  C   . GLU A 1 445 ? 31.122 -19.588 0.13    1    30.91  ? 444  GLU A C   1 
ATOM   3490 O  O   . GLU A 1 445 ? 31.614 -19.117 -0.886  1    31.54  ? 444  GLU A O   1 
ATOM   3491 C  CB  . GLU A 1 445 ? 31.542 -18.397 2.298   1    34.43  ? 444  GLU A CB  1 
ATOM   3492 C  CG  . GLU A 1 445 ? 32.793 -17.695 1.798   1    38.69  ? 444  GLU A CG  1 
ATOM   3493 C  CD  . GLU A 1 445 ? 32.588 -16.278 1.289   1    42.87  ? 444  GLU A CD  1 
ATOM   3494 O  OE1 . GLU A 1 445 ? 31.654 -15.6   1.771   1    38.64  ? 444  GLU A OE1 1 
ATOM   3495 O  OE2 . GLU A 1 445 ? 33.384 -15.84  0.426   1    46.76  ? 444  GLU A OE2 1 
ATOM   3496 N  N   . GLU A 1 446 ? 31.097 -20.901 0.378   1    30.83  ? 445  GLU A N   1 
ATOM   3497 C  CA  . GLU A 1 446 ? 31.657 -21.904 -0.535  1    31.25  ? 445  GLU A CA  1 
ATOM   3498 C  C   . GLU A 1 446 ? 30.867 -21.926 -1.883  1    30.6   ? 445  GLU A C   1 
ATOM   3499 O  O   . GLU A 1 446 ? 31.463 -22.046 -2.95   1    31.07  ? 445  GLU A O   1 
ATOM   3500 C  CB  . GLU A 1 446 ? 31.641 -23.271 0.155   1    34.97  ? 445  GLU A CB  1 
ATOM   3501 C  CG  . GLU A 1 446 ? 32.581 -23.345 1.365   1    42.3   ? 445  GLU A CG  1 
ATOM   3502 C  CD  . GLU A 1 446 ? 32.219 -22.499 2.583   1    51.48  ? 445  GLU A CD  1 
ATOM   3503 O  OE1 . GLU A 1 446 ? 31.037 -22.523 3.002   1    51.24  ? 445  GLU A OE1 1 
ATOM   3504 O  OE2 . GLU A 1 446 ? 33.121 -21.808 3.117   1    55.56  ? 445  GLU A OE2 1 
ATOM   3505 N  N   . GLU A 1 447 ? 29.554 -21.751 -1.822  1    29.57  ? 446  GLU A N   1 
ATOM   3506 C  CA  . GLU A 1 447 ? 28.714 -21.712 -3.022  1    28.38  ? 446  GLU A CA  1 
ATOM   3507 C  C   . GLU A 1 447 ? 28.978 -20.46  -3.82   1    27.66  ? 446  GLU A C   1 
ATOM   3508 O  O   . GLU A 1 447 ? 29.251 -20.557 -5.011  1    26.25  ? 446  GLU A O   1 
ATOM   3509 C  CB  . GLU A 1 447 ? 27.246 -21.872 -2.674  1    30.71  ? 446  GLU A CB  1 
ATOM   3510 C  CG  . GLU A 1 447 ? 26.979 -23.279 -2.177  1    35.75  ? 446  GLU A CG  1 
ATOM   3511 C  CD  . GLU A 1 447 ? 25.616 -23.489 -1.557  1    42.3   ? 446  GLU A CD  1 
ATOM   3512 O  OE1 . GLU A 1 447 ? 24.968 -22.493 -1.163  1    40.78  ? 446  GLU A OE1 1 
ATOM   3513 O  OE2 . GLU A 1 447 ? 25.199 -24.663 -1.451  1    47.64  ? 446  GLU A OE2 1 
ATOM   3514 N  N   . ILE A 1 448 ? 29.113 -19.28  -3.141  1    26.45  ? 447  ILE A N   1 
ATOM   3515 C  CA  . ILE A 1 448 ? 29.473 -18.056 -3.835  1    26.49  ? 447  ILE A CA  1 
ATOM   3516 C  C   . ILE A 1 448 ? 30.826 -18.23  -4.531  1    26.01  ? 447  ILE A C   1 
ATOM   3517 O  O   . ILE A 1 448 ? 30.954 -17.867 -5.69   1    26.53  ? 447  ILE A O   1 
ATOM   3518 C  CB  . ILE A 1 448 ? 29.509 -16.858 -2.818  1    27.14  ? 447  ILE A CB  1 
ATOM   3519 C  CG1 . ILE A 1 448 ? 28.086 -16.485 -2.35   1    28.2   ? 447  ILE A CG1 1 
ATOM   3520 C  CG2 . ILE A 1 448 ? 30.289 -15.669 -3.389  1    28.32  ? 447  ILE A CG2 1 
ATOM   3521 C  CD1 . ILE A 1 448 ? 27.192 -15.808 -3.487  1    29.19  ? 447  ILE A CD1 1 
ATOM   3522 N  N   . GLN A 1 449 ? 31.817 -18.831 -3.838  1    26.29  ? 448  GLN A N   1 
ATOM   3523 C  CA  . GLN A 1 449 ? 33.149 -19.01  -4.417  1    26.63  ? 448  GLN A CA  1 
ATOM   3524 C  C   . GLN A 1 449 ? 33.146 -19.944 -5.652  1    26.08  ? 448  GLN A C   1 
ATOM   3525 O  O   . GLN A 1 449 ? 33.944 -19.728 -6.556  1    26.35  ? 448  GLN A O   1 
ATOM   3526 C  CB  . GLN A 1 449 ? 34.183 -19.44  -3.369  1    29.37  ? 448  GLN A CB  1 
ATOM   3527 C  CG  . GLN A 1 449 ? 34.509 -18.312 -2.357  1    33.76  ? 448  GLN A CG  1 
ATOM   3528 C  CD  . GLN A 1 449 ? 34.855 -16.979 -2.995  1    38.24  ? 448  GLN A CD  1 
ATOM   3529 O  OE1 . GLN A 1 449 ? 35.679 -16.901 -3.911  1    39.61  ? 448  GLN A OE1 1 
ATOM   3530 N  NE2 . GLN A 1 449 ? 34.244 -15.896 -2.501  1    39.03  ? 448  GLN A NE2 1 
ATOM   3531 N  N   . PHE A 1 450 ? 32.196 -20.877 -5.733  1    26.2   ? 449  PHE A N   1 
ATOM   3532 C  CA  . PHE A 1 450 ? 32.065 -21.713 -6.956  1    26.28  ? 449  PHE A CA  1 
ATOM   3533 C  C   . PHE A 1 450 ? 31.664 -20.806 -8.139  1    24.77  ? 449  PHE A C   1 
ATOM   3534 O  O   . PHE A 1 450 ? 32.271 -20.874 -9.204  1    24.44  ? 449  PHE A O   1 
ATOM   3535 C  CB  . PHE A 1 450 ? 31.025 -22.806 -6.766  1    26.86  ? 449  PHE A CB  1 
ATOM   3536 C  CG  . PHE A 1 450 ? 30.878 -23.643 -8.02   1    28.32  ? 449  PHE A CG  1 
ATOM   3537 C  CD1 . PHE A 1 450 ? 31.788 -24.642 -8.314  1    29.1   ? 449  PHE A CD1 1 
ATOM   3538 C  CD2 . PHE A 1 450 ? 29.924 -23.324 -8.975  1    29.42  ? 449  PHE A CD2 1 
ATOM   3539 C  CE1 . PHE A 1 450 ? 31.662 -25.393 -9.484  1    30.21  ? 449  PHE A CE1 1 
ATOM   3540 C  CE2 . PHE A 1 450 ? 29.816 -24.07  -10.146 1    29.95  ? 449  PHE A CE2 1 
ATOM   3541 C  CZ  . PHE A 1 450 ? 30.665 -25.111 -10.372 1    29.83  ? 449  PHE A CZ  1 
ATOM   3542 N  N   . TYR A 1 451 ? 30.645 -19.932 -7.956  1    24.48  ? 450  TYR A N   1 
ATOM   3543 C  CA  . TYR A 1 451 ? 30.257 -19     -9.027  1    23.91  ? 450  TYR A CA  1 
ATOM   3544 C  C   . TYR A 1 451 ? 31.411 -18.08  -9.399  1    24.93  ? 450  TYR A C   1 
ATOM   3545 O  O   . TYR A 1 451 ? 31.719 -17.887 -10.574 1    25.64  ? 450  TYR A O   1 
ATOM   3546 C  CB  . TYR A 1 451 ? 29.041 -18.171 -8.594  1    23.88  ? 450  TYR A CB  1 
ATOM   3547 C  CG  . TYR A 1 451 ? 27.749 -18.953 -8.612  1    24.29  ? 450  TYR A CG  1 
ATOM   3548 C  CD1 . TYR A 1 451 ? 26.965 -19.016 -9.762  1    25.46  ? 450  TYR A CD1 1 
ATOM   3549 C  CD2 . TYR A 1 451 ? 27.284 -19.588 -7.473  1    25.05  ? 450  TYR A CD2 1 
ATOM   3550 C  CE1 . TYR A 1 451 ? 25.746 -19.686 -9.764  1    25.77  ? 450  TYR A CE1 1 
ATOM   3551 C  CE2 . TYR A 1 451 ? 26.058 -20.246 -7.461  1    26.57  ? 450  TYR A CE2 1 
ATOM   3552 C  CZ  . TYR A 1 451 ? 25.313 -20.327 -8.625  1    26.89  ? 450  TYR A CZ  1 
ATOM   3553 O  OH  . TYR A 1 451 ? 24.079 -20.935 -8.593  1    27.4   ? 450  TYR A OH  1 
ATOM   3554 N  N   . VAL A 1 452 ? 32.134 -17.545 -8.385  1    25.07  ? 451  VAL A N   1 
ATOM   3555 C  CA  . VAL A 1 452 ? 33.293 -16.688 -8.646  1    25.24  ? 451  VAL A CA  1 
ATOM   3556 C  C   . VAL A 1 452 ? 34.311 -17.417 -9.572  1    24.59  ? 451  VAL A C   1 
ATOM   3557 O  O   . VAL A 1 452 ? 34.709 -16.868 -10.598 1    25.35  ? 451  VAL A O   1 
ATOM   3558 C  CB  . VAL A 1 452 ? 33.967 -16.266 -7.304  1    26.92  ? 451  VAL A CB  1 
ATOM   3559 C  CG1 . VAL A 1 452 ? 35.31  -15.58  -7.582  1    28.14  ? 451  VAL A CG1 1 
ATOM   3560 C  CG2 . VAL A 1 452 ? 33.038 -15.349 -6.513  1    27.96  ? 451  VAL A CG2 1 
ATOM   3561 N  N   A GLN A 1 453 ? 34.696 -18.647 -9.219  0.5  24.59  ? 452  GLN A N   1 
ATOM   3562 N  N   B GLN A 1 453 ? 34.649 -18.669 -9.205  0.5  24.6   ? 452  GLN A N   1 
ATOM   3563 C  CA  A GLN A 1 453 ? 35.673 -19.385 -10.021 0.5  25.16  ? 452  GLN A CA  1 
ATOM   3564 C  CA  B GLN A 1 453 ? 35.584 -19.554 -9.906  0.5  25.27  ? 452  GLN A CA  1 
ATOM   3565 C  C   A GLN A 1 453 ? 35.159 -19.646 -11.443 0.5  24.88  ? 452  GLN A C   1 
ATOM   3566 C  C   B GLN A 1 453 ? 35.15  -19.726 -11.376 0.5  25.1   ? 452  GLN A C   1 
ATOM   3567 O  O   A GLN A 1 453 ? 35.915 -19.451 -12.396 0.5  24.69  ? 452  GLN A O   1 
ATOM   3568 O  O   B GLN A 1 453 ? 35.961 -19.592 -12.288 0.5  25.31  ? 452  GLN A O   1 
ATOM   3569 C  CB  A GLN A 1 453 ? 36.128 -20.672 -9.324  0.5  26.63  ? 452  GLN A CB  1 
ATOM   3570 C  CB  B GLN A 1 453 ? 35.616 -20.942 -9.222  0.5  26.89  ? 452  GLN A CB  1 
ATOM   3571 C  CG  A GLN A 1 453 ? 36.947 -20.438 -8.043  0.5  29.57  ? 452  GLN A CG  1 
ATOM   3572 C  CG  B GLN A 1 453 ? 36.447 -21.067 -7.924  0.5  31.8   ? 452  GLN A CG  1 
ATOM   3573 C  CD  A GLN A 1 453 ? 38.162 -19.564 -8.251  0.5  34.18  ? 452  GLN A CD  1 
ATOM   3574 C  CD  B GLN A 1 453 ? 36.033 -22.256 -7.055  0.5  37.21  ? 452  GLN A CD  1 
ATOM   3575 O  OE1 A GLN A 1 453 ? 39.012 -19.818 -9.116  0.5  36.18  ? 452  GLN A OE1 1 
ATOM   3576 O  OE1 B GLN A 1 453 ? 35.982 -22.168 -5.82   0.5  39.76  ? 452  GLN A OE1 1 
ATOM   3577 N  NE2 A GLN A 1 453 ? 38.26  -18.509 -7.465  0.5  34.05  ? 452  GLN A NE2 1 
ATOM   3578 N  NE2 B GLN A 1 453 ? 35.726 -23.405 -7.664  0.5  36.68  ? 452  GLN A NE2 1 
ATOM   3579 N  N   . GLN A 1 454 ? 33.862 -19.962 -11.598 1    24.62  ? 453  GLN A N   1 
ATOM   3580 C  CA  . GLN A 1 454 ? 33.308 -20.193 -12.934 1    24.71  ? 453  GLN A CA  1 
ATOM   3581 C  C   . GLN A 1 454 ? 33.401 -18.966 -13.819 1    25.49  ? 453  GLN A C   1 
ATOM   3582 O  O   . GLN A 1 454 ? 33.808 -19.065 -14.967 1    27     ? 453  GLN A O   1 
ATOM   3583 C  CB  . GLN A 1 454 ? 31.848 -20.674 -12.84  1    23.56  ? 453  GLN A CB  1 
ATOM   3584 C  CG  . GLN A 1 454 ? 31.729 -22.025 -12.169 1    23.55  ? 453  GLN A CG  1 
ATOM   3585 C  CD  . GLN A 1 454 ? 32.399 -23.101 -12.983 1    28.27  ? 453  GLN A CD  1 
ATOM   3586 O  OE1 . GLN A 1 454 ? 31.958 -23.419 -14.074 1    31.45  ? 453  GLN A OE1 1 
ATOM   3587 N  NE2 . GLN A 1 454 ? 33.472 -23.691 -12.47  1    29.37  ? 453  GLN A NE2 1 
ATOM   3588 N  N   . PHE A 1 455 ? 33.108 -17.798 -13.247 1    24.42  ? 454  PHE A N   1 
ATOM   3589 C  CA  . PHE A 1 455 ? 33.118 -16.566 -13.991 1    24.58  ? 454  PHE A CA  1 
ATOM   3590 C  C   . PHE A 1 455 ? 34.526 -15.976 -14.233 1    26.02  ? 454  PHE A C   1 
ATOM   3591 O  O   . PHE A 1 455 ? 34.673 -15.048 -15.038 1    25.93  ? 454  PHE A O   1 
ATOM   3592 C  CB  . PHE A 1 455 ? 32.186 -15.556 -13.337 1    23.51  ? 454  PHE A CB  1 
ATOM   3593 C  CG  . PHE A 1 455 ? 30.741 -15.836 -13.723 1    23.47  ? 454  PHE A CG  1 
ATOM   3594 C  CD1 . PHE A 1 455 ? 30.026 -16.854 -13.107 1    23.48  ? 454  PHE A CD1 1 
ATOM   3595 C  CD2 . PHE A 1 455 ? 30.124 -15.113 -14.729 1    23.59  ? 454  PHE A CD2 1 
ATOM   3596 C  CE1 . PHE A 1 455 ? 28.693 -17.091 -13.442 1    24.06  ? 454  PHE A CE1 1 
ATOM   3597 C  CE2 . PHE A 1 455 ? 28.798 -15.378 -15.094 1    24.58  ? 454  PHE A CE2 1 
ATOM   3598 C  CZ  . PHE A 1 455 ? 28.09  -16.351 -14.441 1    23.62  ? 454  PHE A CZ  1 
ATOM   3599 N  N   . LYS A 1 456 ? 35.552 -16.537 -13.588 1    27.33  ? 455  LYS A N   1 
ATOM   3600 C  CA  . LYS A 1 456 ? 36.925 -16.086 -13.869 1    28.87  ? 455  LYS A CA  1 
ATOM   3601 C  C   . LYS A 1 456 ? 37.335 -16.453 -15.291 1    30.18  ? 455  LYS A C   1 
ATOM   3602 O  O   . LYS A 1 456 ? 38.136 -15.734 -15.896 1    31.85  ? 455  LYS A O   1 
ATOM   3603 C  CB  . LYS A 1 456 ? 37.908 -16.68  -12.855 1    30.99  ? 455  LYS A CB  1 
ATOM   3604 C  CG  . LYS A 1 456 ? 38.006 -15.822 -11.612 1    36.99  ? 455  LYS A CG  1 
ATOM   3605 C  CD  . LYS A 1 456 ? 38.777 -16.526 -10.529 1    42.83  ? 455  LYS A CD  1 
ATOM   3606 C  CE  . LYS A 1 456 ? 38.885 -15.653 -9.304  1    49.06  ? 455  LYS A CE  1 
ATOM   3607 N  NZ  . LYS A 1 456 ? 39.115 -16.478 -8.083  1    52.3   ? 455  LYS A NZ  1 
ATOM   3608 N  N   . LYS A 1 457 ? 36.789 -17.563 -15.855 1    29.42  ? 456  LYS A N   1 
ATOM   3609 C  CA  . LYS A 1 457 ? 37.204 -17.983 -17.19  1    30.32  ? 456  LYS A CA  1 
ATOM   3610 C  C   . LYS A 1 457 ? 36.813 -17.004 -18.307 1    30.58  ? 456  LYS A C   1 
ATOM   3611 O  O   . LYS A 1 457 ? 37.688 -16.525 -19.038 1    32.14  ? 456  LYS A O   1 
ATOM   3612 C  CB  . LYS A 1 457 ? 36.715 -19.403 -17.503 1    33.81  ? 456  LYS A CB  1 
ATOM   3613 C  CG  . LYS A 1 457 ? 37.123 -19.876 -18.889 1    39.07  ? 456  LYS A CG  1 
ATOM   3614 C  CD  . LYS A 1 457 ? 36.4   -21.154 -19.242 1    44.05  ? 456  LYS A CD  1 
ATOM   3615 C  CE  . LYS A 1 457 ? 36.265 -21.305 -20.729 1    47.46  ? 456  LYS A CE  1 
ATOM   3616 N  NZ  . LYS A 1 457 ? 35.25  -22.323 -21.065 1    48.8   ? 456  LYS A NZ  1 
ATOM   3617 N  N   . SER A 1 458 ? 35.528 -16.682 -18.437 1    28.61  ? 457  SER A N   1 
ATOM   3618 C  CA  . SER A 1 458 ? 35.057 -15.848 -19.534 1    27.35  ? 457  SER A CA  1 
ATOM   3619 C  C   . SER A 1 458 ? 34.433 -14.505 -19.122 1    27.91  ? 457  SER A C   1 
ATOM   3620 O  O   . SER A 1 458 ? 34.162 -13.686 -19.999 1    28.51  ? 457  SER A O   1 
ATOM   3621 C  CB  . SER A 1 458 ? 34.048 -16.637 -20.372 1    27.22  ? 457  SER A CB  1 
ATOM   3622 O  OG  . SER A 1 458 ? 34.613 -17.854 -20.841 1    27.77  ? 457  SER A OG  1 
ATOM   3623 N  N   . GLY A 1 459 ? 34.134 -14.321 -17.837 1    26.97  ? 458  GLY A N   1 
ATOM   3624 C  CA  . GLY A 1 459 ? 33.528 -13.078 -17.383 1    26.83  ? 458  GLY A CA  1 
ATOM   3625 C  C   . GLY A 1 459 ? 32.091 -12.913 -17.847 1    25.87  ? 458  GLY A C   1 
ATOM   3626 O  O   . GLY A 1 459 ? 31.377 -13.904 -18.063 1    25.95  ? 458  GLY A O   1 
ATOM   3627 N  N   . PHE A 1 460 ? 31.661 -11.649 -18.019 1    24.63  ? 459  PHE A N   1 
ATOM   3628 C  CA  . PHE A 1 460 ? 30.279 -11.339 -18.306 1    24.41  ? 459  PHE A CA  1 
ATOM   3629 C  C   . PHE A 1 460 ? 29.971 -10.943 -19.728 1    23.62  ? 459  PHE A C   1 
ATOM   3630 O  O   . PHE A 1 460 ? 28.799 -10.697 -19.995 1    22.79  ? 459  PHE A O   1 
ATOM   3631 C  CB  . PHE A 1 460 ? 29.771 -10.24  -17.329 1    24.92  ? 459  PHE A CB  1 
ATOM   3632 C  CG  . PHE A 1 460 ? 29.54  -10.777 -15.939 1    26.27  ? 459  PHE A CG  1 
ATOM   3633 C  CD1 . PHE A 1 460 ? 30.604 -11.018 -15.084 1    27.51  ? 459  PHE A CD1 1 
ATOM   3634 C  CD2 . PHE A 1 460 ? 28.26  -11.082 -15.495 1    27.44  ? 459  PHE A CD2 1 
ATOM   3635 C  CE1 . PHE A 1 460 ? 30.386 -11.508 -13.799 1    28.32  ? 459  PHE A CE1 1 
ATOM   3636 C  CE2 . PHE A 1 460 ? 28.051 -11.595 -14.228 1    28.53  ? 459  PHE A CE2 1 
ATOM   3637 C  CZ  . PHE A 1 460 ? 29.117 -11.815 -13.391 1    28.32  ? 459  PHE A CZ  1 
ATOM   3638 N  N   . ARG A 1 461 ? 30.933 -10.977 -20.678 1    24.38  ? 460  ARG A N   1 
ATOM   3639 C  CA  . ARG A 1 461 ? 30.601 -10.584 -22.066 1    24.55  ? 460  ARG A CA  1 
ATOM   3640 C  C   . ARG A 1 461 ? 29.537 -11.526 -22.744 1    24.58  ? 460  ARG A C   1 
ATOM   3641 O  O   . ARG A 1 461 ? 28.477 -11.048 -23.224 1    24.84  ? 460  ARG A O   1 
ATOM   3642 C  CB  . ARG A 1 461 ? 31.853 -10.454 -22.937 1    26.98  ? 460  ARG A CB  1 
ATOM   3643 C  CG  . ARG A 1 461 ? 31.516 -10.038 -24.354 1    29.22  ? 460  ARG A CG  1 
ATOM   3644 C  CD  . ARG A 1 461 ? 32.765 -9.763  -25.156 1    33.93  ? 460  ARG A CD  1 
ATOM   3645 N  NE  . ARG A 1 461 ? 32.457 -9.195  -26.467 1    37.17  ? 460  ARG A NE  1 
ATOM   3646 C  CZ  . ARG A 1 461 ? 33.361 -8.607  -27.253 1    39.93  ? 460  ARG A CZ  1 
ATOM   3647 N  NH1 . ARG A 1 461 ? 34.633 -8.532  -26.875 1    38.74  ? 460  ARG A NH1 1 
ATOM   3648 N  NH2 . ARG A 1 461 ? 33.005 -8.118  -28.43  1    40.51  ? 460  ARG A NH2 1 
ATOM   3649 N  N   . GLY A 1 462 ? 29.81  -12.827 -22.731 1    23.32  ? 461  GLY A N   1 
ATOM   3650 C  CA  . GLY A 1 462 ? 28.887 -13.86  -23.248 1    22.61  ? 461  GLY A CA  1 
ATOM   3651 C  C   . GLY A 1 462 ? 27.511 -13.762 -22.586 1    21.88  ? 461  GLY A C   1 
ATOM   3652 O  O   . GLY A 1 462 ? 26.494 -13.511 -23.258 1    21.63  ? 461  GLY A O   1 
ATOM   3653 N  N   . PRO A 1 463 ? 27.498 -13.865 -21.251 1    22.39  ? 462  PRO A N   1 
ATOM   3654 C  CA  . PRO A 1 463 ? 26.242 -13.711 -20.493 1    22.2   ? 462  PRO A CA  1 
ATOM   3655 C  C   . PRO A 1 463 ? 25.451 -12.442 -20.848 1    22.31  ? 462  PRO A C   1 
ATOM   3656 O  O   . PRO A 1 463 ? 24.254 -12.509 -21.123 1    21.45  ? 462  PRO A O   1 
ATOM   3657 C  CB  . PRO A 1 463 ? 26.729 -13.697 -19.038 1    23.12  ? 462  PRO A CB  1 
ATOM   3658 C  CG  . PRO A 1 463 ? 27.943 -14.663 -19.062 1    22.55  ? 462  PRO A CG  1 
ATOM   3659 C  CD  . PRO A 1 463 ? 28.628 -14.242 -20.362 1    21.6   ? 462  PRO A CD  1 
ATOM   3660 N  N   . LEU A 1 464 ? 26.121 -11.256 -20.857 1    22.63  ? 463  LEU A N   1 
ATOM   3661 C  CA  . LEU A 1 464 ? 25.396 -10.009 -21.191 1    22.82  ? 463  LEU A CA  1 
ATOM   3662 C  C   . LEU A 1 464 ? 24.915 -9.979  -22.63  1    21.82  ? 463  LEU A C   1 
ATOM   3663 O  O   . LEU A 1 464 ? 23.896 -9.342  -22.932 1    22.29  ? 463  LEU A O   1 
ATOM   3664 C  CB  . LEU A 1 464 ? 26.264 -8.785  -20.87  1    22.46  ? 463  LEU A CB  1 
ATOM   3665 C  CG  . LEU A 1 464 ? 26.425 -8.513  -19.371 1    23.51  ? 463  LEU A CG  1 
ATOM   3666 C  CD1 . LEU A 1 464 ? 27.621 -7.588  -19.097 1    24.03  ? 463  LEU A CD1 1 
ATOM   3667 C  CD2 . LEU A 1 464 ? 25.158 -7.894  -18.766 1    23.81  ? 463  LEU A CD2 1 
ATOM   3668 N  N   . ASN A 1 465 ? 25.639 -10.624 -23.542 1    20.63  ? 464  ASN A N   1 
ATOM   3669 C  CA  . ASN A 1 465 ? 25.239 -10.68  -24.954 1    20.9   ? 464  ASN A CA  1 
ATOM   3670 C  C   . ASN A 1 465 ? 23.856 -11.337 -25.122 1    21.53  ? 464  ASN A C   1 
ATOM   3671 O  O   . ASN A 1 465 ? 23.183 -11.039 -26.094 1    21.55  ? 464  ASN A O   1 
ATOM   3672 C  CB  . ASN A 1 465 ? 26.283 -11.405 -25.781 1    21.78  ? 464  ASN A CB  1 
ATOM   3673 C  CG  . ASN A 1 465 ? 27.483 -10.552 -26.133 1    24.77  ? 464  ASN A CG  1 
ATOM   3674 O  OD1 . ASN A 1 465 ? 27.519 -9.342  -25.862 1    25.82  ? 464  ASN A OD1 1 
ATOM   3675 N  ND2 . ASN A 1 465 ? 28.48  -11.178 -26.733 1    25.08  ? 464  ASN A ND2 1 
ATOM   3676 N  N   . TRP A 1 466 ? 23.396 -12.171 -24.132 1    21.19  ? 465  TRP A N   1 
ATOM   3677 C  CA  . TRP A 1 466 ? 22.01  -12.711 -24.238 1    21.61  ? 465  TRP A CA  1 
ATOM   3678 C  C   . TRP A 1 466 ? 20.976 -11.558 -24.28  1    22.82  ? 465  TRP A C   1 
ATOM   3679 O  O   . TRP A 1 466 ? 19.917 -11.701 -24.872 1    23.64  ? 465  TRP A O   1 
ATOM   3680 C  CB  . TRP A 1 466 ? 21.715 -13.603 -23.028 1    21     ? 465  TRP A CB  1 
ATOM   3681 C  CG  . TRP A 1 466 ? 22.338 -14.969 -23.131 1    21.3   ? 465  TRP A CG  1 
ATOM   3682 C  CD1 . TRP A 1 466 ? 23.667 -15.275 -23.095 1    21.84  ? 465  TRP A CD1 1 
ATOM   3683 C  CD2 . TRP A 1 466 ? 21.631 -16.221 -23.146 1    20.8   ? 465  TRP A CD2 1 
ATOM   3684 N  NE1 . TRP A 1 466 ? 23.834 -16.651 -23.149 1    21.97  ? 465  TRP A NE1 1 
ATOM   3685 C  CE2 . TRP A 1 466 ? 22.597 -17.248 -23.182 1    22.31  ? 465  TRP A CE2 1 
ATOM   3686 C  CE3 . TRP A 1 466 ? 20.267 -16.564 -23.239 1    21.54  ? 465  TRP A CE3 1 
ATOM   3687 C  CZ2 . TRP A 1 466 ? 22.245 -18.61  -23.21  1    23.21  ? 465  TRP A CZ2 1 
ATOM   3688 C  CZ3 . TRP A 1 466 ? 19.915 -17.913 -23.256 1    22.8   ? 465  TRP A CZ3 1 
ATOM   3689 C  CH2 . TRP A 1 466 ? 20.897 -18.914 -23.25  1    23.04  ? 465  TRP A CH2 1 
ATOM   3690 N  N   . TYR A 1 467 ? 21.291 -10.404 -23.656 1    22.44  ? 466  TYR A N   1 
ATOM   3691 C  CA  . TYR A 1 467 ? 20.372 -9.244  -23.638 1    23.68  ? 466  TYR A CA  1 
ATOM   3692 C  C   . TYR A 1 467 ? 20.535 -8.301  -24.839 1    23.92  ? 466  TYR A C   1 
ATOM   3693 O  O   . TYR A 1 467 ? 19.761 -7.348  -24.971 1    25.79  ? 466  TYR A O   1 
ATOM   3694 C  CB  . TYR A 1 467 ? 20.669 -8.384  -22.389 1    24.39  ? 466  TYR A CB  1 
ATOM   3695 C  CG  . TYR A 1 467 ? 20.277 -9.006  -21.08  1    25.29  ? 466  TYR A CG  1 
ATOM   3696 C  CD1 . TYR A 1 467 ? 19     -8.84   -20.56  1    27.05  ? 466  TYR A CD1 1 
ATOM   3697 C  CD2 . TYR A 1 467 ? 21.178 -9.772  -20.363 1    26.17  ? 466  TYR A CD2 1 
ATOM   3698 C  CE1 . TYR A 1 467 ? 18.639 -9.417  -19.345 1    28.45  ? 466  TYR A CE1 1 
ATOM   3699 C  CE2 . TYR A 1 467 ? 20.838 -10.333 -19.148 1    28.04  ? 466  TYR A CE2 1 
ATOM   3700 C  CZ  . TYR A 1 467 ? 19.58  -10.141 -18.631 1    29.64  ? 466  TYR A CZ  1 
ATOM   3701 O  OH  . TYR A 1 467 ? 19.333 -10.693 -17.401 1    33.49  ? 466  TYR A OH  1 
ATOM   3702 N  N   . ARG A 1 468 ? 21.535 -8.508  -25.678 1    23.28  ? 467  ARG A N   1 
ATOM   3703 C  CA  . ARG A 1 468 ? 21.883 -7.578  -26.743 1    24.27  ? 467  ARG A CA  1 
ATOM   3704 C  C   . ARG A 1 468 ? 21.383 -7.97   -28.138 1    24.87  ? 467  ARG A C   1 
ATOM   3705 O  O   . ARG A 1 468 ? 21.904 -7.518  -29.18  1    25.56  ? 467  ARG A O   1 
ATOM   3706 C  CB  . ARG A 1 468 ? 23.414 -7.396  -26.716 1    24.42  ? 467  ARG A CB  1 
ATOM   3707 C  CG  . ARG A 1 468 ? 23.878 -6.812  -25.392 1    24.1   ? 467  ARG A CG  1 
ATOM   3708 C  CD  . ARG A 1 468 ? 25.395 -6.626  -25.337 1    24.83  ? 467  ARG A CD  1 
ATOM   3709 N  NE  . ARG A 1 468 ? 25.743 -5.932  -24.101 1    25.96  ? 467  ARG A NE  1 
ATOM   3710 C  CZ  . ARG A 1 468 ? 26.878 -6.089  -23.431 1    25.13  ? 467  ARG A CZ  1 
ATOM   3711 N  NH1 . ARG A 1 468 ? 27.778 -6.976  -23.836 1    22.85  ? 467  ARG A NH1 1 
ATOM   3712 N  NH2 . ARG A 1 468 ? 27.113 -5.374  -22.335 1    25.08  ? 467  ARG A NH2 1 
ATOM   3713 N  N   . ASN A 1 469 ? 20.341 -8.815  -28.182 1    23.94  ? 468  ASN A N   1 
ATOM   3714 C  CA  . ASN A 1 469 ? 19.785 -9.27   -29.459 1    23.96  ? 468  ASN A CA  1 
ATOM   3715 C  C   . ASN A 1 469 ? 18.273 -9.03   -29.485 1    25.01  ? 468  ASN A C   1 
ATOM   3716 O  O   . ASN A 1 469 ? 17.556 -9.815  -30.108 1    25.29  ? 468  ASN A O   1 
ATOM   3717 C  CB  . ASN A 1 469 ? 20.077 -10.767 -29.642 1    24.21  ? 468  ASN A CB  1 
ATOM   3718 C  CG  . ASN A 1 469 ? 21.514 -11.045 -29.953 1    24.67  ? 468  ASN A CG  1 
ATOM   3719 O  OD1 . ASN A 1 469 ? 21.965 -10.88  -31.077 1    25.75  ? 468  ASN A OD1 1 
ATOM   3720 N  ND2 . ASN A 1 469 ? 22.278 -11.485 -28.961 1    23.28  ? 468  ASN A ND2 1 
ATOM   3721 N  N   . MET A 1 470 ? 17.771 -7.977  -28.798 1    25.6   ? 469  MET A N   1 
ATOM   3722 C  CA  A MET A 1 470 ? 16.327 -7.757  -28.718 0.5  26.29  ? 469  MET A CA  1 
ATOM   3723 C  CA  B MET A 1 470 ? 16.327 -7.694  -28.744 0.5  27.13  ? 469  MET A CA  1 
ATOM   3724 C  C   . MET A 1 470 ? 15.641 -7.636  -30.106 1    27.25  ? 469  MET A C   1 
ATOM   3725 O  O   . MET A 1 470 ? 14.592 -8.257  -30.309 1    26.98  ? 469  MET A O   1 
ATOM   3726 C  CB  A MET A 1 470 ? 15.998 -6.565  -27.792 0.5  25.87  ? 469  MET A CB  1 
ATOM   3727 C  CB  B MET A 1 470 ? 16.048 -6.382  -27.996 0.5  28.61  ? 469  MET A CB  1 
ATOM   3728 C  CG  A MET A 1 470 ? 16.56  -6.746  -26.349 0.5  25.74  ? 469  MET A CG  1 
ATOM   3729 C  CG  B MET A 1 470 ? 16.218 -6.491  -26.502 0.5  33.51  ? 469  MET A CG  1 
ATOM   3730 S  SD  A MET A 1 470 ? 15.92  -8.201  -25.446 0.5  28.33  ? 469  MET A SD  1 
ATOM   3731 S  SD  B MET A 1 470 ? 16.727 -4.941  -25.723 0.5  46.69  ? 469  MET A SD  1 
ATOM   3732 C  CE  A MET A 1 470 ? 16.746 -8.012  -23.858 0.5  23.11  ? 469  MET A CE  1 
ATOM   3733 C  CE  B MET A 1 470 ? 15.811 -3.734  -26.675 0.5  49     ? 469  MET A CE  1 
ATOM   3734 N  N   A GLU A 1 471 ? 16.212 -6.859  -31.028 0.5  27.67  ? 470  GLU A N   1 
ATOM   3735 N  N   B GLU A 1 471 ? 16.196 -6.863  -31.053 0.5  27.72  ? 470  GLU A N   1 
ATOM   3736 C  CA  A GLU A 1 471 ? 15.63  -6.708  -32.359 0.5  28.4   ? 470  GLU A CA  1 
ATOM   3737 C  CA  B GLU A 1 471 ? 15.592 -6.73   -32.378 0.5  28.53  ? 470  GLU A CA  1 
ATOM   3738 C  C   A GLU A 1 471 ? 15.666 -8.03   -33.143 0.5  28.5   ? 470  GLU A C   1 
ATOM   3739 C  C   B GLU A 1 471 ? 15.683 -8.021  -33.208 0.5  28.61  ? 470  GLU A C   1 
ATOM   3740 O  O   A GLU A 1 471 ? 14.664 -8.423  -33.745 0.5  29.02  ? 470  GLU A O   1 
ATOM   3741 O  O   B GLU A 1 471 ? 14.729 -8.383  -33.902 0.5  29.18  ? 470  GLU A O   1 
ATOM   3742 C  CB  A GLU A 1 471 ? 16.375 -5.611  -33.132 0.5  31.11  ? 470  GLU A CB  1 
ATOM   3743 C  CB  B GLU A 1 471 ? 16.181 -5.522  -33.11  0.5  31.37  ? 470  GLU A CB  1 
ATOM   3744 C  CG  A GLU A 1 471 ? 15.726 -5.239  -34.451 0.5  36.87  ? 470  GLU A CG  1 
ATOM   3745 C  CG  B GLU A 1 471 ? 15.928 -4.226  -32.354 0.5  36.85  ? 470  GLU A CG  1 
ATOM   3746 C  CD  A GLU A 1 471 ? 14.836 -4.011  -34.4   0.5  45.26  ? 470  GLU A CD  1 
ATOM   3747 C  CD  B GLU A 1 471 ? 16.592 -2.996  -32.937 0.5  47.18  ? 470  GLU A CD  1 
ATOM   3748 O  OE1 A GLU A 1 471 ? 14.213 -3.761  -33.341 0.5  45.73  ? 470  GLU A OE1 1 
ATOM   3749 O  OE1 B GLU A 1 471 ? 16.781 -2.951  -34.174 0.5  49.27  ? 470  GLU A OE1 1 
ATOM   3750 O  OE2 A GLU A 1 471 ? 14.762 -3.296  -35.425 0.5  48.51  ? 470  GLU A OE2 1 
ATOM   3751 O  OE2 B GLU A 1 471 ? 16.911 -2.068  -32.156 0.5  51     ? 470  GLU A OE2 1 
ATOM   3752 N  N   . ARG A 1 472 ? 16.811 -8.721  -33.125 1    28     ? 471  ARG A N   1 
ATOM   3753 C  CA  . ARG A 1 472 ? 16.991 -9.976  -33.84  1    28.18  ? 471  ARG A CA  1 
ATOM   3754 C  C   . ARG A 1 472 ? 15.988 -11.033 -33.318 1    26.06  ? 471  ARG A C   1 
ATOM   3755 O  O   . ARG A 1 472 ? 15.334 -11.721 -34.113 1    25.93  ? 471  ARG A O   1 
ATOM   3756 C  CB  . ARG A 1 472 ? 18.425 -10.437 -33.56  1    31.31  ? 471  ARG A CB  1 
ATOM   3757 C  CG  . ARG A 1 472 ? 19.095 -11.17  -34.66  1    37     ? 471  ARG A CG  1 
ATOM   3758 C  CD  . ARG A 1 472 ? 20.57  -11.264 -34.301 1    42.24  ? 471  ARG A CD  1 
ATOM   3759 N  NE  . ARG A 1 472 ? 21.389 -10.294 -35.024 1    47.61  ? 471  ARG A NE  1 
ATOM   3760 C  CZ  . ARG A 1 472 ? 22.085 -9.313  -34.448 1    51.55  ? 471  ARG A CZ  1 
ATOM   3761 N  NH1 . ARG A 1 472 ? 22.021 -9.123  -33.13  1    49.76  ? 471  ARG A NH1 1 
ATOM   3762 N  NH2 . ARG A 1 472 ? 22.829 -8.498  -35.187 1    52.14  ? 471  ARG A NH2 1 
ATOM   3763 N  N   . ASN A 1 473 ? 15.848 -11.125 -31.986 1    24.99  ? 472  ASN A N   1 
ATOM   3764 C  CA  . ASN A 1 473 ? 14.939 -12.086 -31.347 1    24.57  ? 472  ASN A CA  1 
ATOM   3765 C  C   . ASN A 1 473 ? 13.496 -11.775 -31.685 1    24.97  ? 472  ASN A C   1 
ATOM   3766 O  O   . ASN A 1 473 ? 12.694 -12.699 -31.886 1    24.55  ? 472  ASN A O   1 
ATOM   3767 C  CB  . ASN A 1 473 ? 15.126 -12.1   -29.837 1    23.89  ? 472  ASN A CB  1 
ATOM   3768 C  CG  . ASN A 1 473 ? 16.463 -12.662 -29.405 1    25.71  ? 472  ASN A CG  1 
ATOM   3769 O  OD1 . ASN A 1 473 ? 17.22  -13.239 -30.208 1    25.3   ? 472  ASN A OD1 1 
ATOM   3770 N  ND2 . ASN A 1 473 ? 16.787 -12.491 -28.114 1    25.68  ? 472  ASN A ND2 1 
ATOM   3771 N  N   . TRP A 1 474 ? 13.161 -10.478 -31.733 1    24.36  ? 473  TRP A N   1 
ATOM   3772 C  CA  . TRP A 1 474 ? 11.816 -10.016 -32.079 1    26.21  ? 473  TRP A CA  1 
ATOM   3773 C  C   . TRP A 1 474 ? 11.458 -10.396 -33.535 1    25.46  ? 473  TRP A C   1 
ATOM   3774 O  O   . TRP A 1 474 ? 10.375 -10.966 -33.777 1    25.76  ? 473  TRP A O   1 
ATOM   3775 C  CB  . TRP A 1 474 ? 11.724 -8.5    -31.833 1    27.61  ? 473  TRP A CB  1 
ATOM   3776 C  CG  . TRP A 1 474 ? 10.431 -7.876  -32.272 1    30.25  ? 473  TRP A CG  1 
ATOM   3777 C  CD1 . TRP A 1 474 ? 9.259  -7.831  -31.576 1    31.71  ? 473  TRP A CD1 1 
ATOM   3778 C  CD2 . TRP A 1 474 ? 10.231 -7.095  -33.448 1    32     ? 473  TRP A CD2 1 
ATOM   3779 N  NE1 . TRP A 1 474 ? 8.325  -7.1    -32.272 1    32.37  ? 473  TRP A NE1 1 
ATOM   3780 C  CE2 . TRP A 1 474 ? 8.892  -6.651  -33.435 1    33.24  ? 473  TRP A CE2 1 
ATOM   3781 C  CE3 . TRP A 1 474 ? 11.049 -6.734  -34.521 1    34.22  ? 473  TRP A CE3 1 
ATOM   3782 C  CZ2 . TRP A 1 474 ? 8.35   -5.888  -34.474 1    35.17  ? 473  TRP A CZ2 1 
ATOM   3783 C  CZ3 . TRP A 1 474 ? 10.517 -5.956  -35.533 1    36.31  ? 473  TRP A CZ3 1 
ATOM   3784 C  CH2 . TRP A 1 474 ? 9.175  -5.561  -35.51  1    36.08  ? 473  TRP A CH2 1 
ATOM   3785 N  N   . LYS A 1 475 ? 12.376 -10.147 -34.512 1    25.32  ? 474  LYS A N   1 
ATOM   3786 C  CA  . LYS A 1 475 ? 12.107 -10.514 -35.919 1    25.72  ? 474  LYS A CA  1 
ATOM   3787 C  C   . LYS A 1 475 ? 11.869 -12.049 -36.03  1    25.55  ? 474  LYS A C   1 
ATOM   3788 O  O   . LYS A 1 475 ? 10.975 -12.488 -36.735 1    25.12  ? 474  LYS A O   1 
ATOM   3789 C  CB  . LYS A 1 475 ? 13.301 -10.139 -36.812 1    28.73  ? 474  LYS A CB  1 
ATOM   3790 C  CG  . LYS A 1 475 ? 13.434 -8.646  -37.062 1    35.13  ? 474  LYS A CG  1 
ATOM   3791 C  CD  . LYS A 1 475 ? 14.441 -8.41   -38.184 1    41.31  ? 474  LYS A CD  1 
ATOM   3792 C  CE  . LYS A 1 475 ? 14.906 -6.973  -38.244 1    47.5   ? 474  LYS A CE  1 
ATOM   3793 N  NZ  . LYS A 1 475 ? 13.751 -6.05   -38.311 1    51.67  ? 474  LYS A NZ  1 
ATOM   3794 N  N   . TRP A 1 476 ? 12.677 -12.851 -35.305 1    24.91  ? 475  TRP A N   1 
ATOM   3795 C  CA  . TRP A 1 476 ? 12.547 -14.292 -35.358 1    25.1   ? 475  TRP A CA  1 
ATOM   3796 C  C   . TRP A 1 476 ? 11.239 -14.733 -34.678 1    24.72  ? 475  TRP A C   1 
ATOM   3797 O  O   . TRP A 1 476 ? 10.468 -15.494 -35.266 1    25.27  ? 475  TRP A O   1 
ATOM   3798 C  CB  . TRP A 1 476 ? 13.771 -14.943 -34.709 1    25.8   ? 475  TRP A CB  1 
ATOM   3799 C  CG  . TRP A 1 476 ? 13.803 -16.426 -34.852 1    26.75  ? 475  TRP A CG  1 
ATOM   3800 C  CD1 . TRP A 1 476 ? 13.92  -17.128 -36.013 1    27.97  ? 475  TRP A CD1 1 
ATOM   3801 C  CD2 . TRP A 1 476 ? 13.944 -17.383 -33.785 1    26.92  ? 475  TRP A CD2 1 
ATOM   3802 N  NE1 . TRP A 1 476 ? 14.072 -18.477 -35.736 1    28.19  ? 475  TRP A NE1 1 
ATOM   3803 C  CE2 . TRP A 1 476 ? 14.104 -18.651 -34.377 1    27.73  ? 475  TRP A CE2 1 
ATOM   3804 C  CE3 . TRP A 1 476 ? 13.949 -17.283 -32.39  1    27.83  ? 475  TRP A CE3 1 
ATOM   3805 C  CZ2 . TRP A 1 476 ? 14.197 -19.822 -33.617 1    28.46  ? 475  TRP A CZ2 1 
ATOM   3806 C  CZ3 . TRP A 1 476 ? 14.039 -18.443 -31.639 1    28.46  ? 475  TRP A CZ3 1 
ATOM   3807 C  CH2 . TRP A 1 476 ? 14.178 -19.687 -32.249 1    28.39  ? 475  TRP A CH2 1 
ATOM   3808 N  N   . ALA A 1 477 ? 10.927 -14.181 -33.499 1    24.56  ? 476  ALA A N   1 
ATOM   3809 C  CA  . ALA A 1 477 ? 9.714  -14.541 -32.779 1    25.66  ? 476  ALA A CA  1 
ATOM   3810 C  C   . ALA A 1 477 ? 8.469  -14.217 -33.588 1    26.34  ? 476  ALA A C   1 
ATOM   3811 O  O   . ALA A 1 477 ? 7.501  -14.958 -33.519 1    26.11  ? 476  ALA A O   1 
ATOM   3812 C  CB  . ALA A 1 477 ? 9.661  -13.843 -31.419 1    25.53  ? 476  ALA A CB  1 
ATOM   3813 N  N   . CYS A 1 478 ? 8.5    -13.121 -34.38  1    26.61  ? 477  CYS A N   1 
ATOM   3814 C  CA  . CYS A 1 478 ? 7.327  -12.748 -35.175 1    27.54  ? 477  CYS A CA  1 
ATOM   3815 C  C   . CYS A 1 478 ? 6.953  -13.837 -36.201 1    28.65  ? 477  CYS A C   1 
ATOM   3816 O  O   . CYS A 1 478 ? 5.79   -13.925 -36.589 1    29.85  ? 477  CYS A O   1 
ATOM   3817 C  CB  . CYS A 1 478 ? 7.525  -11.394 -35.84  1    28.76  ? 477  CYS A CB  1 
ATOM   3818 S  SG  . CYS A 1 478 ? 7.372  -9.993  -34.696 1    30.72  ? 477  CYS A SG  1 
ATOM   3819 N  N   . LYS A 1 479 ? 7.913  -14.663 -36.626 1    28.03  ? 478  LYS A N   1 
ATOM   3820 C  CA  . LYS A 1 479 ? 7.609  -15.77  -37.549 1    28.99  ? 478  LYS A CA  1 
ATOM   3821 C  C   . LYS A 1 479 ? 6.684  -16.821 -36.914 1    29.27  ? 478  LYS A C   1 
ATOM   3822 O  O   . LYS A 1 479 ? 6.049  -17.602 -37.636 1    30.11  ? 478  LYS A O   1 
ATOM   3823 C  CB  . LYS A 1 479 ? 8.906  -16.474 -37.969 1    31.25  ? 478  LYS A CB  1 
ATOM   3824 C  CG  . LYS A 1 479 ? 9.944  -15.561 -38.6   1    36.65  ? 478  LYS A CG  1 
ATOM   3825 C  CD  . LYS A 1 479 ? 11.134 -16.398 -39.072 1    42.53  ? 478  LYS A CD  1 
ATOM   3826 C  CE  . LYS A 1 479 ? 12.129 -15.586 -39.873 1    48.24  ? 478  LYS A CE  1 
ATOM   3827 N  NZ  . LYS A 1 479 ? 11.465 -14.5   -40.646 1    51.82  ? 478  LYS A NZ  1 
ATOM   3828 N  N   . SER A 1 480 ? 6.621  -16.872 -35.573 1    28.37  ? 479  SER A N   1 
ATOM   3829 C  CA  . SER A 1 480 ? 5.858  -17.881 -34.86  1    28.36  ? 479  SER A CA  1 
ATOM   3830 C  C   . SER A 1 480 ? 4.491  -17.424 -34.357 1    28.17  ? 479  SER A C   1 
ATOM   3831 O  O   . SER A 1 480 ? 3.837  -18.186 -33.655 1    28.12  ? 479  SER A O   1 
ATOM   3832 C  CB  . SER A 1 480 ? 6.69   -18.403 -33.687 1    29.8   ? 479  SER A CB  1 
ATOM   3833 O  OG  . SER A 1 480 ? 6.777  -17.467 -32.618 1    29.59  ? 479  SER A OG  1 
ATOM   3834 N  N   . LEU A 1 481 ? 4.061  -16.195 -34.677 1    27.97  ? 480  LEU A N   1 
ATOM   3835 C  CA  . LEU A 1 481 ? 2.832  -15.624 -34.127 1    28.71  ? 480  LEU A CA  1 
ATOM   3836 C  C   . LEU A 1 481 ? 1.528  -16.369 -34.46  1    29.06  ? 480  LEU A C   1 
ATOM   3837 O  O   . LEU A 1 481 ? 0.555  -16.258 -33.699 1    30.26  ? 480  LEU A O   1 
ATOM   3838 C  CB  . LEU A 1 481 ? 2.704  -14.151 -34.511 1    29.23  ? 480  LEU A CB  1 
ATOM   3839 C  CG  . LEU A 1 481 ? 3.753  -13.242 -33.869 1    30.71  ? 480  LEU A CG  1 
ATOM   3840 C  CD1 . LEU A 1 481 ? 3.618  -11.81  -34.372 1    31.25  ? 480  LEU A CD1 1 
ATOM   3841 C  CD2 . LEU A 1 481 ? 3.653  -13.289 -32.369 1    32.4   ? 480  LEU A CD2 1 
ATOM   3842 N  N   . GLY A 1 482 ? 1.522  -17.12  -35.543 1    28.18  ? 481  GLY A N   1 
ATOM   3843 C  CA  . GLY A 1 482 ? 0.349  -17.918 -35.892 1    28.26  ? 481  GLY A CA  1 
ATOM   3844 C  C   . GLY A 1 482 ? 0.285  -19.261 -35.174 1    28.85  ? 481  GLY A C   1 
ATOM   3845 O  O   . GLY A 1 482 ? -0.71  -19.987 -35.295 1    29.56  ? 481  GLY A O   1 
ATOM   3846 N  N   . ARG A 1 483 ? 1.346  -19.618 -34.432 1    27.28  ? 482  ARG A N   1 
ATOM   3847 C  CA  . ARG A 1 483 ? 1.416  -20.906 -33.751 1    27.54  ? 482  ARG A CA  1 
ATOM   3848 C  C   . ARG A 1 483 ? 0.879  -20.867 -32.337 1    28.05  ? 482  ARG A C   1 
ATOM   3849 O  O   . ARG A 1 483 ? 0.851  -19.814 -31.695 1    29.32  ? 482  ARG A O   1 
ATOM   3850 C  CB  . ARG A 1 483 ? 2.894  -21.383 -33.687 1    27.37  ? 482  ARG A CB  1 
ATOM   3851 C  CG  . ARG A 1 483 ? 3.595  -21.464 -35.017 1    27.73  ? 482  ARG A CG  1 
ATOM   3852 C  CD  . ARG A 1 483 ? 5.066  -21.899 -34.901 1    25.62  ? 482  ARG A CD  1 
ATOM   3853 N  NE  . ARG A 1 483 ? 5.771  -21.511 -36.114 1    26.17  ? 482  ARG A NE  1 
ATOM   3854 C  CZ  . ARG A 1 483 ? 7.077  -21.321 -36.212 1    26.89  ? 482  ARG A CZ  1 
ATOM   3855 N  NH1 . ARG A 1 483 ? 7.867  -21.514 -35.154 1    27.64  ? 482  ARG A NH1 1 
ATOM   3856 N  NH2 . ARG A 1 483 ? 7.607  -20.919 -37.358 1    25.42  ? 482  ARG A NH2 1 
ATOM   3857 N  N   . LYS A 1 484 ? 0.576  -22.05  -31.798 1    27.55  ? 483  LYS A N   1 
ATOM   3858 C  CA  . LYS A 1 484 ? 0.295  -22.236 -30.39  1    28.18  ? 483  LYS A CA  1 
ATOM   3859 C  C   . LYS A 1 484 ? 1.235  -23.345 -29.873 1    28.35  ? 483  LYS A C   1 
ATOM   3860 O  O   . LYS A 1 484 ? 1.78   -24.115 -30.659 1    29.02  ? 483  LYS A O   1 
ATOM   3861 C  CB  . LYS A 1 484 ? -1.18  -22.603 -30.144 1    30.66  ? 483  LYS A CB  1 
ATOM   3862 C  CG  . LYS A 1 484 ? -2.115 -21.441 -30.499 1    34.84  ? 483  LYS A CG  1 
ATOM   3863 C  CD  . LYS A 1 484 ? -3.5   -21.647 -29.951 1    41.58  ? 483  LYS A CD  1 
ATOM   3864 C  CE  . LYS A 1 484 ? -4.372 -20.437 -30.172 1    47.38  ? 483  LYS A CE  1 
ATOM   3865 N  NZ  . LYS A 1 484 ? -5.64  -20.555 -29.397 1    52.01  ? 483  LYS A NZ  1 
ATOM   3866 N  N   . ILE A 1 485 ? 1.453  -23.385 -28.565 1    27.25  ? 484  ILE A N   1 
ATOM   3867 C  CA  . ILE A 1 485 ? 2.255  -24.433 -27.957 1    26.85  ? 484  ILE A CA  1 
ATOM   3868 C  C   . ILE A 1 485 ? 1.269  -25.461 -27.477 1    27.01  ? 484  ILE A C   1 
ATOM   3869 O  O   . ILE A 1 485 ? 0.479  -25.202 -26.576 1    27.79  ? 484  ILE A O   1 
ATOM   3870 C  CB  . ILE A 1 485 ? 3.16   -23.888 -26.833 1    27.14  ? 484  ILE A CB  1 
ATOM   3871 C  CG1 . ILE A 1 485 ? 4.19   -22.929 -27.428 1    27.87  ? 484  ILE A CG1 1 
ATOM   3872 C  CG2 . ILE A 1 485 ? 3.859  -25.043 -26.116 1    27.6   ? 484  ILE A CG2 1 
ATOM   3873 C  CD1 . ILE A 1 485 ? 5.025  -22.169 -26.306 1    29.04  ? 484  ILE A CD1 1 
ATOM   3874 N  N   . LEU A 1 486 ? 1.272  -26.618 -28.132 1    26.78  ? 485  LEU A N   1 
ATOM   3875 C  CA  . LEU A 1 486 ? 0.326  -27.678 -27.847 1    27.18  ? 485  LEU A CA  1 
ATOM   3876 C  C   . LEU A 1 486 ? 0.955  -28.931 -27.221 1    27.9   ? 485  LEU A C   1 
ATOM   3877 O  O   . LEU A 1 486 ? 0.224  -29.871 -26.886 1    29.01  ? 485  LEU A O   1 
ATOM   3878 C  CB  . LEU A 1 486 ? -0.462 -28.017 -29.116 1    27.12  ? 485  LEU A CB  1 
ATOM   3879 C  CG  . LEU A 1 486 ? -1.283 -26.855 -29.678 1    29.55  ? 485  LEU A CG  1 
ATOM   3880 C  CD1 . LEU A 1 486 ? -1.907 -27.22  -31.037 1    30.39  ? 485  LEU A CD1 1 
ATOM   3881 C  CD2 . LEU A 1 486 ? -2.344 -26.386 -28.683 1    31.13  ? 485  LEU A CD2 1 
ATOM   3882 N  N   . ILE A 1 487 ? 2.287  -28.933 -27     1    26.18  ? 486  ILE A N   1 
ATOM   3883 C  CA  . ILE A 1 487 ? 2.934  -30.031 -26.286 1    25.74  ? 486  ILE A CA  1 
ATOM   3884 C  C   . ILE A 1 487 ? 2.789  -29.774 -24.746 1    25.56  ? 486  ILE A C   1 
ATOM   3885 O  O   . ILE A 1 487 ? 2.394  -28.671 -24.333 1    26.26  ? 486  ILE A O   1 
ATOM   3886 C  CB  . ILE A 1 487 ? 4.405  -30.158 -26.74  1    25.41  ? 486  ILE A CB  1 
ATOM   3887 C  CG1 . ILE A 1 487 ? 5.197  -28.89  -26.301 1    25.11  ? 486  ILE A CG1 1 
ATOM   3888 C  CG2 . ILE A 1 487 ? 4.489  -30.381 -28.269 1    26.14  ? 486  ILE A CG2 1 
ATOM   3889 C  CD1 . ILE A 1 487 ? 6.655  -29.048 -26.502 1    26.14  ? 486  ILE A CD1 1 
ATOM   3890 N  N   . PRO A 1 488 ? 3.067  -30.776 -23.882 1    24.89  ? 487  PRO A N   1 
ATOM   3891 C  CA  . PRO A 1 488 ? 2.858  -30.576 -22.435 1    25.13  ? 487  PRO A CA  1 
ATOM   3892 C  C   . PRO A 1 488 ? 3.721  -29.45  -21.896 1    24.08  ? 487  PRO A C   1 
ATOM   3893 O  O   . PRO A 1 488 ? 4.899  -29.374 -22.253 1    23.8   ? 487  PRO A O   1 
ATOM   3894 C  CB  . PRO A 1 488 ? 3.24   -31.918 -21.832 1    25.93  ? 487  PRO A CB  1 
ATOM   3895 C  CG  . PRO A 1 488 ? 3.003  -32.911 -22.967 1    26.5   ? 487  PRO A CG  1 
ATOM   3896 C  CD  . PRO A 1 488 ? 3.483  -32.161 -24.177 1    24.69  ? 487  PRO A CD  1 
ATOM   3897 N  N   . ALA A 1 489 ? 3.111  -28.537 -21.16  1    23.62  ? 488  ALA A N   1 
ATOM   3898 C  CA  . ALA A 1 489 ? 3.815  -27.344 -20.678 1    23.45  ? 488  ALA A CA  1 
ATOM   3899 C  C   . ALA A 1 489 ? 3.439  -26.988 -19.249 1    24.35  ? 488  ALA A C   1 
ATOM   3900 O  O   . ALA A 1 489 ? 2.274  -27.105 -18.852 1    25.16  ? 488  ALA A O   1 
ATOM   3901 C  CB  . ALA A 1 489 ? 3.485  -26.165 -21.583 1    22.88  ? 488  ALA A CB  1 
ATOM   3902 N  N   . LEU A 1 490 ? 4.412  -26.457 -18.495 1    22.42  ? 489  LEU A N   1 
ATOM   3903 C  CA  . LEU A 1 490 ? 4.222  -26.019 -17.132 1    21.74  ? 489  LEU A CA  1 
ATOM   3904 C  C   . LEU A 1 490 ? 4.789  -24.614 -16.961 1    22.11  ? 489  LEU A C   1 
ATOM   3905 O  O   . LEU A 1 490 ? 5.902  -24.344 -17.417 1    22.02  ? 489  LEU A O   1 
ATOM   3906 C  CB  . LEU A 1 490 ? 4.952  -26.984 -16.179 1    22.68  ? 489  LEU A CB  1 
ATOM   3907 C  CG  . LEU A 1 490 ? 5.045  -26.569 -14.704 1    25.35  ? 489  LEU A CG  1 
ATOM   3908 C  CD1 . LEU A 1 490 ? 3.687  -26.73  -14.002 1    27.28  ? 489  LEU A CD1 1 
ATOM   3909 C  CD2 . LEU A 1 490 ? 6.054  -27.442 -13.933 1    25.06  ? 489  LEU A CD2 1 
ATOM   3910 N  N   . MET A 1 491 ? 4.04   -23.74  -16.305 1    21.92  ? 490  MET A N   1 
ATOM   3911 C  CA  . MET A 1 491 ? 4.515  -22.386 -15.99  1    22.47  ? 490  MET A CA  1 
ATOM   3912 C  C   . MET A 1 491 ? 4.55   -22.294 -14.457 1    24.68  ? 490  MET A C   1 
ATOM   3913 O  O   . MET A 1 491 ? 3.505  -22.499 -13.802 1    25.14  ? 490  MET A O   1 
ATOM   3914 C  CB  . MET A 1 491 ? 3.572  -21.317 -16.589 1    22.37  ? 490  MET A CB  1 
ATOM   3915 C  CG  . MET A 1 491 ? 3.915  -19.886 -16.153 1    22.97  ? 490  MET A CG  1 
ATOM   3916 S  SD  . MET A 1 491 ? 5.549  -19.419 -16.844 1    25.33  ? 490  MET A SD  1 
ATOM   3917 C  CE  . MET A 1 491 ? 6.098  -18.231 -15.623 1    27.51  ? 490  MET A CE  1 
ATOM   3918 N  N   . VAL A 1 492 ? 5.742  -22.031 -13.866 1    23.75  ? 491  VAL A N   1 
ATOM   3919 C  CA  . VAL A 1 492 ? 5.86   -21.883 -12.409 1    24.39  ? 491  VAL A CA  1 
ATOM   3920 C  C   . VAL A 1 492 ? 6.112  -20.417 -12.06  1    25.32  ? 491  VAL A C   1 
ATOM   3921 O  O   . VAL A 1 492 ? 7.14   -19.868 -12.441 1    24.99  ? 491  VAL A O   1 
ATOM   3922 C  CB  . VAL A 1 492 ? 6.963  -22.769 -11.788 1    25.06  ? 491  VAL A CB  1 
ATOM   3923 C  CG1 . VAL A 1 492 ? 6.921  -22.701 -10.264 1    25.95  ? 491  VAL A CG1 1 
ATOM   3924 C  CG2 . VAL A 1 492 ? 6.851  -24.202 -12.287 1    25.14  ? 491  VAL A CG2 1 
ATOM   3925 N  N   . THR A 1 493 ? 5.188  -19.781 -11.322 1    25.6   ? 492  THR A N   1 
ATOM   3926 C  CA  . THR A 1 493 ? 5.383  -18.381 -10.925 1    26.41  ? 492  THR A CA  1 
ATOM   3927 C  C   . THR A 1 493 ? 5.931  -18.264 -9.502  1    27.09  ? 492  THR A C   1 
ATOM   3928 O  O   . THR A 1 493 ? 5.716  -19.157 -8.675  1    27.02  ? 492  THR A O   1 
ATOM   3929 C  CB  . THR A 1 493 ? 4.098  -17.576 -11.116 1    27.9   ? 492  THR A CB  1 
ATOM   3930 O  OG1 . THR A 1 493 ? 3.029  -18.28  -10.476 1    28.95  ? 492  THR A OG1 1 
ATOM   3931 C  CG2 . THR A 1 493 ? 3.764  -17.362 -12.597 1    28.2   ? 492  THR A CG2 1 
ATOM   3932 N  N   . ALA A 1 494 ? 6.676  -17.175 -9.231  1    26.73  ? 493  ALA A N   1 
ATOM   3933 C  CA  . ALA A 1 494 ? 7.284  -16.928 -7.935  1    28.25  ? 493  ALA A CA  1 
ATOM   3934 C  C   . ALA A 1 494 ? 6.673  -15.633 -7.413  1    28.98  ? 493  ALA A C   1 
ATOM   3935 O  O   . ALA A 1 494 ? 6.826  -14.609 -8.046  1    28.72  ? 493  ALA A O   1 
ATOM   3936 C  CB  . ALA A 1 494 ? 8.799  -16.76  -8.093  1    29.39  ? 493  ALA A CB  1 
ATOM   3937 N  N   . GLU A 1 495 ? 5.949  -15.698 -6.294  1    30.03  ? 494  GLU A N   1 
ATOM   3938 C  CA  . GLU A 1 495 ? 5.226  -14.555 -5.714  1    31.39  ? 494  GLU A CA  1 
ATOM   3939 C  C   . GLU A 1 495 ? 6.027  -13.247 -5.625  1    32.2   ? 494  GLU A C   1 
ATOM   3940 O  O   . GLU A 1 495 ? 5.542  -12.177 -6.022  1    34.04  ? 494  GLU A O   1 
ATOM   3941 C  CB  . GLU A 1 495 ? 4.674  -14.933 -4.32   1    33.44  ? 494  GLU A CB  1 
ATOM   3942 C  CG  . GLU A 1 495 ? 3.877  -13.81  -3.661  1    38.05  ? 494  GLU A CG  1 
ATOM   3943 C  CD  . GLU A 1 495 ? 3.527  -13.997 -2.196  1    45.86  ? 494  GLU A CD  1 
ATOM   3944 O  OE1 . GLU A 1 495 ? 4.141  -14.865 -1.536  1    45.07  ? 494  GLU A OE1 1 
ATOM   3945 O  OE2 . GLU A 1 495 ? 2.65   -13.256 -1.696  1    50.2   ? 494  GLU A OE2 1 
ATOM   3946 N  N   . LYS A 1 496 ? 7.24   -13.334 -5.125  1    30.45  ? 495  LYS A N   1 
ATOM   3947 C  CA  . LYS A 1 496 ? 8.064  -12.172 -4.875  1    30.34  ? 495  LYS A CA  1 
ATOM   3948 C  C   . LYS A 1 496 ? 9.176  -11.928 -5.884  1    29.92  ? 495  LYS A C   1 
ATOM   3949 O  O   . LYS A 1 496 ? 10.154 -11.287 -5.528  1    30.31  ? 495  LYS A O   1 
ATOM   3950 C  CB  . LYS A 1 496 ? 8.625  -12.245 -3.453  1    33.21  ? 495  LYS A CB  1 
ATOM   3951 C  CG  . LYS A 1 496 ? 7.524  -12.421 -2.406  1    40.46  ? 495  LYS A CG  1 
ATOM   3952 C  CD  . LYS A 1 496 ? 7.632  -11.407 -1.283  1    47.82  ? 495  LYS A CD  1 
ATOM   3953 C  CE  . LYS A 1 496 ? 6.454  -11.475 -0.343  1    53.51  ? 495  LYS A CE  1 
ATOM   3954 N  NZ  . LYS A 1 496 ? 6.536  -12.665 0.546   1    57.46  ? 495  LYS A NZ  1 
ATOM   3955 N  N   . ASP A 1 497 ? 9.043  -12.408 -7.138  1    29.46  ? 496  ASP A N   1 
ATOM   3956 C  CA  . ASP A 1 497 ? 9.986  -12     -8.186  1    30.05  ? 496  ASP A CA  1 
ATOM   3957 C  C   . ASP A 1 497 ? 9.373  -10.653 -8.678  1    31.72  ? 496  ASP A C   1 
ATOM   3958 O  O   . ASP A 1 497 ? 8.314  -10.665 -9.308  1    30.96  ? 496  ASP A O   1 
ATOM   3959 C  CB  . ASP A 1 497 ? 10.029 -13.007 -9.357  1    29.35  ? 496  ASP A CB  1 
ATOM   3960 C  CG  . ASP A 1 497 ? 11.108 -12.653 -10.355 1    31.83  ? 496  ASP A CG  1 
ATOM   3961 O  OD1 . ASP A 1 497 ? 11.365 -11.434 -10.543 1    31.01  ? 496  ASP A OD1 1 
ATOM   3962 O  OD2 . ASP A 1 497 ? 11.695 -13.605 -10.991 1    31.02  ? 496  ASP A OD2 1 
ATOM   3963 N  N   . PHE A 1 498 ? 10.02  -9.509  -8.384  1    33.27  ? 497  PHE A N   1 
ATOM   3964 C  CA  . PHE A 1 498 ? 9.461  -8.206  -8.771  1    34.7   ? 497  PHE A CA  1 
ATOM   3965 C  C   . PHE A 1 498 ? 9.788  -7.77   -10.198 1    35.21  ? 497  PHE A C   1 
ATOM   3966 O  O   . PHE A 1 498 ? 9.327  -6.699  -10.627 1    36.3   ? 497  PHE A O   1 
ATOM   3967 C  CB  . PHE A 1 498 ? 9.85   -7.12   -7.754  1    35.7   ? 497  PHE A CB  1 
ATOM   3968 C  CG  . PHE A 1 498 ? 9.378  -7.523  -6.371  1    37.69  ? 497  PHE A CG  1 
ATOM   3969 C  CD1 . PHE A 1 498 ? 8.046  -7.826  -6.138  1    39.27  ? 497  PHE A CD1 1 
ATOM   3970 C  CD2 . PHE A 1 498 ? 10.276 -7.679  -5.331  1    39     ? 497  PHE A CD2 1 
ATOM   3971 C  CE1 . PHE A 1 498 ? 7.618  -8.239  -4.875  1    40.16  ? 497  PHE A CE1 1 
ATOM   3972 C  CE2 . PHE A 1 498 ? 9.843  -8.074  -4.068  1    40.06  ? 497  PHE A CE2 1 
ATOM   3973 C  CZ  . PHE A 1 498 ? 8.519  -8.333  -3.842  1    39.94  ? 497  PHE A CZ  1 
ATOM   3974 N  N   . VAL A 1 499 ? 10.52  -8.604  -10.971 1    33.33  ? 498  VAL A N   1 
ATOM   3975 C  CA  . VAL A 1 499 ? 10.783 -8.289  -12.366 1    32.41  ? 498  VAL A CA  1 
ATOM   3976 C  C   . VAL A 1 499 ? 9.91   -9.212  -13.22  1    31.2   ? 498  VAL A C   1 
ATOM   3977 O  O   . VAL A 1 499 ? 9.074  -8.735  -13.994 1    31.32  ? 498  VAL A O   1 
ATOM   3978 C  CB  . VAL A 1 499 ? 12.278 -8.407  -12.712 1    33.9   ? 498  VAL A CB  1 
ATOM   3979 C  CG1 . VAL A 1 499 ? 12.496 -8.342  -14.225 1    34.87  ? 498  VAL A CG1 1 
ATOM   3980 C  CG2 . VAL A 1 499 ? 13.077 -7.334  -11.98  1    34.44  ? 498  VAL A CG2 1 
ATOM   3981 N  N   . LEU A 1 500 ? 10.037 -10.535 -13.004 1    29.39  ? 499  LEU A N   1 
ATOM   3982 C  CA  . LEU A 1 500 ? 9.224  -11.533 -13.702 1    28.78  ? 499  LEU A CA  1 
ATOM   3983 C  C   . LEU A 1 500 ? 8.06   -11.855 -12.755 1    29.74  ? 499  LEU A C   1 
ATOM   3984 O  O   . LEU A 1 500 ? 8.027  -12.905 -12.104 1    29.64  ? 499  LEU A O   1 
ATOM   3985 C  CB  . LEU A 1 500 ? 10.068 -12.787 -13.979 1    27.54  ? 499  LEU A CB  1 
ATOM   3986 C  CG  . LEU A 1 500 ? 11.331 -12.559 -14.839 1    28.95  ? 499  LEU A CG  1 
ATOM   3987 C  CD1 . LEU A 1 500 ? 12.094 -13.864 -15.022 1    28.24  ? 499  LEU A CD1 1 
ATOM   3988 C  CD2 . LEU A 1 500 ? 10.957 -12     -16.198 1    30.13  ? 499  LEU A CD2 1 
ATOM   3989 N  N   . VAL A 1 501 ? 7.133  -10.895 -12.638 1    30.42  ? 500  VAL A N   1 
ATOM   3990 C  CA  . VAL A 1 501 ? 5.99   -11.001 -11.728 1    30.94  ? 500  VAL A CA  1 
ATOM   3991 C  C   . VAL A 1 501 ? 4.97   -12.023 -12.224 1    30.65  ? 500  VAL A C   1 
ATOM   3992 O  O   . VAL A 1 501 ? 4.757  -12.175 -13.43  1    30.3   ? 500  VAL A O   1 
ATOM   3993 C  CB  . VAL A 1 501 ? 5.334  -9.607  -11.45  1    33.84  ? 500  VAL A CB  1 
ATOM   3994 C  CG1 . VAL A 1 501 ? 6.394  -8.558  -11.108 1    35.46  ? 500  VAL A CG1 1 
ATOM   3995 C  CG2 . VAL A 1 501 ? 4.507  -9.142  -12.638 1    34.25  ? 500  VAL A CG2 1 
ATOM   3996 N  N   . PRO A 1 502 ? 4.322  -12.739 -11.285 1    30.69  ? 501  PRO A N   1 
ATOM   3997 C  CA  . PRO A 1 502 ? 3.344  -13.763 -11.684 1    30.86  ? 501  PRO A CA  1 
ATOM   3998 C  C   . PRO A 1 502 ? 2.247  -13.283 -12.63  1    31.45  ? 501  PRO A C   1 
ATOM   3999 O  O   . PRO A 1 502 ? 1.829  -14.017 -13.525 1    30.95  ? 501  PRO A O   1 
ATOM   4000 C  CB  . PRO A 1 502 ? 2.758  -14.224 -10.34  1    31.18  ? 501  PRO A CB  1 
ATOM   4001 C  CG  . PRO A 1 502 ? 3.845  -14.013 -9.369  1    31.65  ? 501  PRO A CG  1 
ATOM   4002 C  CD  . PRO A 1 502 ? 4.525  -12.73  -9.825  1    30.63  ? 501  PRO A CD  1 
ATOM   4003 N  N   . GLN A 1 503 ? 1.77   -12.046 -12.427 1    32.69  ? 502  GLN A N   1 
ATOM   4004 C  CA  . GLN A 1 503 ? 0.717  -11.418 -13.225 1    33.9   ? 502  GLN A CA  1 
ATOM   4005 C  C   . GLN A 1 503 ? 1.093  -11.32  -14.723 1    32.77  ? 502  GLN A C   1 
ATOM   4006 O  O   . GLN A 1 503 ? 0.22   -11.391 -15.586 1    32.83  ? 502  GLN A O   1 
ATOM   4007 C  CB  . GLN A 1 503 ? 0.39   -10.031 -12.624 1    38.51  ? 502  GLN A CB  1 
ATOM   4008 C  CG  . GLN A 1 503 ? -0.538 -9.167  -13.459 1    47.96  ? 502  GLN A CG  1 
ATOM   4009 C  CD  . GLN A 1 503 ? -1.91  -9.09   -12.848 1    58.16  ? 502  GLN A CD  1 
ATOM   4010 O  OE1 . GLN A 1 503 ? -2.386 -8.008  -12.465 1    60.5   ? 502  GLN A OE1 1 
ATOM   4011 N  NE2 . GLN A 1 503 ? -2.575 -10.24  -12.743 1    60.79  ? 502  GLN A NE2 1 
ATOM   4012 N  N   . MET A 1 504 ? 2.396  -11.234 -15.033 1    31.43  ? 503  MET A N   1 
ATOM   4013 C  CA  . MET A 1 504 ? 2.848  -11.185 -16.423 1    31.76  ? 503  MET A CA  1 
ATOM   4014 C  C   . MET A 1 504 ? 2.5    -12.466 -17.193 1    31.16  ? 503  MET A C   1 
ATOM   4015 O  O   . MET A 1 504 ? 2.451  -12.423 -18.409 1    31.93  ? 503  MET A O   1 
ATOM   4016 C  CB  . MET A 1 504 ? 4.359  -10.967 -16.48  1    32.61  ? 503  MET A CB  1 
ATOM   4017 C  CG  . MET A 1 504 ? 4.781  -9.522  -16.318 1    36.54  ? 503  MET A CG  1 
ATOM   4018 S  SD  . MET A 1 504 ? 6.595  -9.362  -16.116 1    46.04  ? 503  MET A SD  1 
ATOM   4019 C  CE  . MET A 1 504 ? 7.205  -10.46  -17.393 1    40.16  ? 503  MET A CE  1 
ATOM   4020 N  N   . SER A 1 505 ? 2.297  -13.598 -16.485 1    30.28  ? 504  SER A N   1 
ATOM   4021 C  CA  . SER A 1 505 ? 1.974  -14.893 -17.095 1    30.16  ? 504  SER A CA  1 
ATOM   4022 C  C   . SER A 1 505 ? 0.449  -15.11  -17.281 1    30.72  ? 504  SER A C   1 
ATOM   4023 O  O   . SER A 1 505 ? 0.059  -16.179 -17.747 1    30.67  ? 504  SER A O   1 
ATOM   4024 C  CB  . SER A 1 505 ? 2.5    -16.024 -16.207 1    30.13  ? 504  SER A CB  1 
ATOM   4025 O  OG  . SER A 1 505 ? 1.682  -16.22  -15.057 1    31.38  ? 504  SER A OG  1 
ATOM   4026 N  N   . GLN A 1 506 ? -0.397 -14.147 -16.874 1    31.44  ? 505  GLN A N   1 
ATOM   4027 C  CA  . GLN A 1 506 ? -1.863 -14.33  -16.86  1    32.19  ? 505  GLN A CA  1 
ATOM   4028 C  C   . GLN A 1 506 ? -2.567 -14.663 -18.189 1    33.29  ? 505  GLN A C   1 
ATOM   4029 O  O   . GLN A 1 506 ? -3.637 -15.29  -18.147 1    34.3   ? 505  GLN A O   1 
ATOM   4030 C  CB  . GLN A 1 506 ? -2.549 -13.118 -16.237 1    33.14  ? 505  GLN A CB  1 
ATOM   4031 C  CG  . GLN A 1 506 ? -2.479 -11.866 -17.086 1    36.91  ? 505  GLN A CG  1 
ATOM   4032 C  CD  . GLN A 1 506 ? -3.084 -10.701 -16.345 1    44.43  ? 505  GLN A CD  1 
ATOM   4033 O  OE1 . GLN A 1 506 ? -4.086 -10.842 -15.635 1    47.16  ? 505  GLN A OE1 1 
ATOM   4034 N  NE2 . GLN A 1 506 ? -2.478 -9.528  -16.495 1    44.83  ? 505  GLN A NE2 1 
ATOM   4035 N  N   . HIS A 1 507 ? -2.024 -14.263 -19.341 1    32.62  ? 506  HIS A N   1 
ATOM   4036 C  CA  . HIS A 1 507 ? -2.678 -14.573 -20.626 1    32.57  ? 506  HIS A CA  1 
ATOM   4037 C  C   . HIS A 1 507 ? -2.107 -15.799 -21.355 1    29.57  ? 506  HIS A C   1 
ATOM   4038 O  O   . HIS A 1 507 ? -2.491 -16.064 -22.49  1    28.72  ? 506  HIS A O   1 
ATOM   4039 C  CB  . HIS A 1 507 ? -2.608 -13.353 -21.54  1    35.36  ? 506  HIS A CB  1 
ATOM   4040 C  CG  . HIS A 1 507 ? -3.231 -12.142 -20.911 1    41.34  ? 506  HIS A CG  1 
ATOM   4041 N  ND1 . HIS A 1 507 ? -4.559 -12.146 -20.507 1    44.01  ? 506  HIS A ND1 1 
ATOM   4042 C  CD2 . HIS A 1 507 ? -2.688 -10.935 -20.625 1    43.95  ? 506  HIS A CD2 1 
ATOM   4043 C  CE1 . HIS A 1 507 ? -4.781 -10.947 -19.982 1    45.25  ? 506  HIS A CE1 1 
ATOM   4044 N  NE2 . HIS A 1 507 ? -3.692 -10.18  -20.029 1    45.41  ? 506  HIS A NE2 1 
ATOM   4045 N  N   . MET A 1 508 ? -1.174 -16.519 -20.733 1    28.1   ? 507  MET A N   1 
ATOM   4046 C  CA  . MET A 1 508 ? -0.496 -17.624 -21.401 1    27.37  ? 507  MET A CA  1 
ATOM   4047 C  C   . MET A 1 508 ? -1.43  -18.694 -21.959 1    27.38  ? 507  MET A C   1 
ATOM   4048 O  O   . MET A 1 508 ? -1.111 -19.28  -22.989 1    27.63  ? 507  MET A O   1 
ATOM   4049 C  CB  . MET A 1 508 ? 0.564  -18.229 -20.474 1    27.46  ? 507  MET A CB  1 
ATOM   4050 C  CG  . MET A 1 508 ? 1.799  -17.324 -20.386 1    28.52  ? 507  MET A CG  1 
ATOM   4051 S  SD  . MET A 1 508 ? 3.008  -17.946 -19.213 1    26.6   ? 507  MET A SD  1 
ATOM   4052 C  CE  . MET A 1 508 ? 3.425  -19.47  -19.95  1    24.71  ? 507  MET A CE  1 
ATOM   4053 N  N   . GLU A 1 509 ? -2.577 -18.943 -21.306 1    27.62  ? 508  GLU A N   1 
ATOM   4054 C  CA  . GLU A 1 509 ? -3.51  -19.979 -21.808 1    28.41  ? 508  GLU A CA  1 
ATOM   4055 C  C   . GLU A 1 509 ? -4.082 -19.676 -23.192 1    29.35  ? 508  GLU A C   1 
ATOM   4056 O  O   . GLU A 1 509 ? -4.483 -20.597 -23.908 1    29.78  ? 508  GLU A O   1 
ATOM   4057 C  CB  . GLU A 1 509 ? -4.645 -20.246 -20.788 1    30.12  ? 508  GLU A CB  1 
ATOM   4058 C  CG  . GLU A 1 509 ? -4.167 -21.087 -19.622 1    31.84  ? 508  GLU A CG  1 
ATOM   4059 C  CD  . GLU A 1 509 ? -3.615 -20.305 -18.446 1    35.76  ? 508  GLU A CD  1 
ATOM   4060 O  OE1 . GLU A 1 509 ? -3.408 -19.074 -18.576 1    35.73  ? 508  GLU A OE1 1 
ATOM   4061 O  OE2 . GLU A 1 509 ? -3.407 -20.928 -17.378 1    39.09  ? 508  GLU A OE2 1 
ATOM   4062 N  N   . ASP A 1 510 ? -4.069 -18.409 -23.602 1    29.67  ? 509  ASP A N   1 
ATOM   4063 C  CA  . ASP A 1 510 ? -4.522 -18.048 -24.954 1    30.98  ? 509  ASP A CA  1 
ATOM   4064 C  C   . ASP A 1 510 ? -3.636 -18.708 -26.021 1    31.6   ? 509  ASP A C   1 
ATOM   4065 O  O   . ASP A 1 510 ? -4.113 -19.012 -27.111 1    32.29  ? 509  ASP A O   1 
ATOM   4066 C  CB  . ASP A 1 510 ? -4.479 -16.52  -25.134 1    33.36  ? 509  ASP A CB  1 
ATOM   4067 C  CG  . ASP A 1 510 ? -5.46  -15.763 -24.241 1    40.03  ? 509  ASP A CG  1 
ATOM   4068 O  OD1 . ASP A 1 510 ? -6.341 -16.409 -23.644 1    41.28  ? 509  ASP A OD1 1 
ATOM   4069 O  OD2 . ASP A 1 510 ? -5.333 -14.526 -24.136 1    42.94  ? 509  ASP A OD2 1 
ATOM   4070 N  N   . TRP A 1 511 ? -2.337 -18.926 -25.705 1    30.76  ? 510  TRP A N   1 
ATOM   4071 C  CA  . TRP A 1 511 ? -1.345 -19.476 -26.63  1    30.87  ? 510  TRP A CA  1 
ATOM   4072 C  C   . TRP A 1 511 ? -0.867 -20.887 -26.285 1    29.03  ? 510  TRP A C   1 
ATOM   4073 O  O   . TRP A 1 511 ? -0.303 -21.57  -27.153 1    29.22  ? 510  TRP A O   1 
ATOM   4074 C  CB  . TRP A 1 511 ? -0.154 -18.491 -26.765 1    32.4   ? 510  TRP A CB  1 
ATOM   4075 C  CG  . TRP A 1 511 ? -0.6   -17.052 -26.839 1    35.36  ? 510  TRP A CG  1 
ATOM   4076 C  CD1 . TRP A 1 511 ? -0.504 -16.12  -25.846 1    37.5   ? 510  TRP A CD1 1 
ATOM   4077 C  CD2 . TRP A 1 511 ? -1.459 -16.483 -27.839 1    37.06  ? 510  TRP A CD2 1 
ATOM   4078 N  NE1 . TRP A 1 511 ? -1.178 -14.972 -26.208 1    38.56  ? 510  TRP A NE1 1 
ATOM   4079 C  CE2 . TRP A 1 511 ? -1.746 -15.16  -27.442 1    38.37  ? 510  TRP A CE2 1 
ATOM   4080 C  CE3 . TRP A 1 511 ? -1.986 -16.955 -29.048 1    38.3   ? 510  TRP A CE3 1 
ATOM   4081 C  CZ2 . TRP A 1 511 ? -2.51  -14.298 -28.226 1    39.64  ? 510  TRP A CZ2 1 
ATOM   4082 C  CZ3 . TRP A 1 511 ? -2.724 -16.092 -29.831 1    39.96  ? 510  TRP A CZ3 1 
ATOM   4083 C  CH2 . TRP A 1 511 ? -2.985 -14.783 -29.415 1    40.13  ? 510  TRP A CH2 1 
ATOM   4084 N  N   . ILE A 1 512 ? -1.115 -21.337 -25.051 1    27.7   ? 511  ILE A N   1 
ATOM   4085 C  CA  . ILE A 1 512 ? -0.725 -22.669 -24.56  1    27.29  ? 511  ILE A CA  1 
ATOM   4086 C  C   . ILE A 1 512 ? -1.986 -23.181 -23.862 1    29.04  ? 511  ILE A C   1 
ATOM   4087 O  O   . ILE A 1 512 ? -2.089 -23.113 -22.635 1    29.01  ? 511  ILE A O   1 
ATOM   4088 C  CB  . ILE A 1 512 ? 0.473  -22.54  -23.535 1    25.84  ? 511  ILE A CB  1 
ATOM   4089 C  CG1 . ILE A 1 512 ? 1.534  -21.505 -24.015 1    26.49  ? 511  ILE A CG1 1 
ATOM   4090 C  CG2 . ILE A 1 512 ? 1.103  -23.915 -23.286 1    25.42  ? 511  ILE A CG2 1 
ATOM   4091 C  CD1 . ILE A 1 512 ? 2.811  -21.357 -23.134 1    26.56  ? 511  ILE A CD1 1 
ATOM   4092 N  N   . PRO A 1 513 ? -3.018 -23.564 -24.633 1    30.71  ? 512  PRO A N   1 
ATOM   4093 C  CA  . PRO A 1 513 ? -4.328 -23.871 -24.014 1    31.5   ? 512  PRO A CA  1 
ATOM   4094 C  C   . PRO A 1 513 ? -4.345 -24.941 -22.935 1    32.27  ? 512  PRO A C   1 
ATOM   4095 O  O   . PRO A 1 513 ? -5.144 -24.821 -21.988 1    33.5   ? 512  PRO A O   1 
ATOM   4096 C  CB  . PRO A 1 513 ? -5.207 -24.286 -25.206 1    32.4   ? 512  PRO A CB  1 
ATOM   4097 C  CG  . PRO A 1 513 ? -4.29  -24.535 -26.333 1    32.75  ? 512  PRO A CG  1 
ATOM   4098 C  CD  . PRO A 1 513 ? -3.081 -23.661 -26.106 1    30.99  ? 512  PRO A CD  1 
ATOM   4099 N  N   . HIS A 1 514 ? -3.463 -25.948 -23.051 1    31.88  ? 513  HIS A N   1 
ATOM   4100 C  CA  . HIS A 1 514 ? -3.37  -27.066 -22.078 1    32.91  ? 513  HIS A CA  1 
ATOM   4101 C  C   . HIS A 1 514 ? -2.335 -26.811 -20.941 1    31.13  ? 513  HIS A C   1 
ATOM   4102 O  O   . HIS A 1 514 ? -1.994 -27.728 -20.202 1    31.18  ? 513  HIS A O   1 
ATOM   4103 C  CB  . HIS A 1 514 ? -3.01  -28.379 -22.809 1    36.07  ? 513  HIS A CB  1 
ATOM   4104 C  CG  . HIS A 1 514 ? -3.792 -28.622 -24.072 1    42.47  ? 513  HIS A CG  1 
ATOM   4105 N  ND1 . HIS A 1 514 ? -5.183 -28.639 -24.07  1    44.86  ? 513  HIS A ND1 1 
ATOM   4106 C  CD2 . HIS A 1 514 ? -3.349 -28.828 -25.341 1    44.47  ? 513  HIS A CD2 1 
ATOM   4107 C  CE1 . HIS A 1 514 ? -5.542 -28.847 -25.33  1    46.13  ? 513  HIS A CE1 1 
ATOM   4108 N  NE2 . HIS A 1 514 ? -4.474 -28.957 -26.139 1    46.1   ? 513  HIS A NE2 1 
ATOM   4109 N  N   . LEU A 1 515 ? -1.818 -25.583 -20.826 1    29.56  ? 514  LEU A N   1 
ATOM   4110 C  CA  . LEU A 1 515 ? -0.812 -25.227 -19.822 1    28.13  ? 514  LEU A CA  1 
ATOM   4111 C  C   . LEU A 1 515 ? -1.181 -25.659 -18.398 1    27.65  ? 514  LEU A C   1 
ATOM   4112 O  O   . LEU A 1 515 ? -2.338 -25.517 -17.978 1    27.64  ? 514  LEU A O   1 
ATOM   4113 C  CB  . LEU A 1 515 ? -0.631 -23.699 -19.828 1    27.06  ? 514  LEU A CB  1 
ATOM   4114 C  CG  . LEU A 1 515 ? 0.381  -23.14  -18.811 1    27.08  ? 514  LEU A CG  1 
ATOM   4115 C  CD1 . LEU A 1 515 ? 1.797  -23.518 -19.243 1    27.37  ? 514  LEU A CD1 1 
ATOM   4116 C  CD2 . LEU A 1 515 ? 0.245  -21.635 -18.716 1    27.06  ? 514  LEU A CD2 1 
ATOM   4117 N  N   . LYS A 1 516 ? -0.215 -26.248 -17.69  1    26.68  ? 515  LYS A N   1 
ATOM   4118 C  CA  . LYS A 1 516 ? -0.339 -26.562 -16.276 1    26.05  ? 515  LYS A CA  1 
ATOM   4119 C  C   . LYS A 1 516 ? 0.457  -25.505 -15.507 1    26.03  ? 515  LYS A C   1 
ATOM   4120 O  O   . LYS A 1 516 ? 1.363  -24.851 -16.064 1    26.06  ? 515  LYS A O   1 
ATOM   4121 C  CB  . LYS A 1 516 ? 0.165  -27.963 -15.977 1    27.75  ? 515  LYS A CB  1 
ATOM   4122 C  CG  . LYS A 1 516 ? -0.706 -29.012 -16.66  1    32.82  ? 515  LYS A CG  1 
ATOM   4123 C  CD  . LYS A 1 516 ? -0.498 -30.369 -16.04  1    39.31  ? 515  LYS A CD  1 
ATOM   4124 C  CE  . LYS A 1 516 ? -1.516 -31.38  -16.519 1    44.49  ? 515  LYS A CE  1 
ATOM   4125 N  NZ  . LYS A 1 516 ? -1.306 -32.683 -15.836 1    47.43  ? 515  LYS A NZ  1 
ATOM   4126 N  N   . ARG A 1 517 ? 0.087  -25.289 -14.249 1    25.13  ? 516  ARG A N   1 
ATOM   4127 C  CA  . ARG A 1 517 ? 0.758  -24.275 -13.437 1    25.39  ? 516  ARG A CA  1 
ATOM   4128 C  C   . ARG A 1 517 ? 1.228  -24.759 -12.085 1    27.58  ? 516  ARG A C   1 
ATOM   4129 O  O   . ARG A 1 517 ? 0.699  -25.707 -11.496 1    28.35  ? 516  ARG A O   1 
ATOM   4130 C  CB  . ARG A 1 517 ? -0.147 -23.041 -13.253 1    26.61  ? 516  ARG A CB  1 
ATOM   4131 C  CG  . ARG A 1 517 ? -0.399 -22.252 -14.525 1    28.06  ? 516  ARG A CG  1 
ATOM   4132 C  CD  . ARG A 1 517 ? -1.321 -21.093 -14.216 1    29.15  ? 516  ARG A CD  1 
ATOM   4133 N  NE  . ARG A 1 517 ? -1.523 -20.231 -15.381 1    30.77  ? 516  ARG A NE  1 
ATOM   4134 C  CZ  . ARG A 1 517 ? -0.777 -19.165 -15.666 1    31.62  ? 516  ARG A CZ  1 
ATOM   4135 N  NH1 . ARG A 1 517 ? 0.225  -18.811 -14.864 1    30.08  ? 516  ARG A NH1 1 
ATOM   4136 N  NH2 . ARG A 1 517 ? -1.055 -18.42  -16.73  1    29.52  ? 516  ARG A NH2 1 
ATOM   4137 N  N   . GLY A 1 518 ? 2.198  -24.032 -11.568 1    27.43  ? 517  GLY A N   1 
ATOM   4138 C  CA  . GLY A 1 518 ? 2.719  -24.132 -10.218 1    27.77  ? 517  GLY A CA  1 
ATOM   4139 C  C   . GLY A 1 518 ? 2.936  -22.713 -9.724  1    27.83  ? 517  GLY A C   1 
ATOM   4140 O  O   . GLY A 1 518 ? 3.123  -21.794 -10.526 1    28.3   ? 517  GLY A O   1 
ATOM   4141 N  N   . HIS A 1 519 ? 2.872  -22.503 -8.419  1    28.49  ? 518  HIS A N   1 
ATOM   4142 C  CA  . HIS A 1 519 ? 3.079  -21.16  -7.855  1    29.17  ? 518  HIS A CA  1 
ATOM   4143 C  C   . HIS A 1 519 ? 3.757  -21.31  -6.522  1    28.92  ? 518  HIS A C   1 
ATOM   4144 O  O   . HIS A 1 519 ? 3.335  -22.142 -5.71   1    29.64  ? 518  HIS A O   1 
ATOM   4145 C  CB  . HIS A 1 519 ? 1.738  -20.4   -7.706  1    30.19  ? 518  HIS A CB  1 
ATOM   4146 C  CG  . HIS A 1 519 ? 1.91   -19.033 -7.127  1    33.23  ? 518  HIS A CG  1 
ATOM   4147 N  ND1 . HIS A 1 519 ? 1.54   -18.749 -5.818  1    35.7   ? 518  HIS A ND1 1 
ATOM   4148 C  CD2 . HIS A 1 519 ? 2.468  -17.923 -7.671  1    34.05  ? 518  HIS A CD2 1 
ATOM   4149 C  CE1 . HIS A 1 519 ? 1.851  -17.476 -5.628  1    35.73  ? 518  HIS A CE1 1 
ATOM   4150 N  NE2 . HIS A 1 519 ? 2.421  -16.944 -6.707  1    36.39  ? 518  HIS A NE2 1 
ATOM   4151 N  N   . ILE A 1 520 ? 4.832  -20.545 -6.303  1    28.04  ? 519  ILE A N   1 
ATOM   4152 C  CA  . ILE A 1 520 ? 5.615  -20.593 -5.081  1    27.98  ? 519  ILE A CA  1 
ATOM   4153 C  C   . ILE A 1 520 ? 5.508  -19.287 -4.297  1    28.45  ? 519  ILE A C   1 
ATOM   4154 O  O   . ILE A 1 520 ? 5.871  -18.216 -4.781  1    27.95  ? 519  ILE A O   1 
ATOM   4155 C  CB  . ILE A 1 520 ? 7.09   -20.99  -5.348  1    28.23  ? 519  ILE A CB  1 
ATOM   4156 C  CG1 . ILE A 1 520 ? 7.136  -22.305 -6.177  1    29.36  ? 519  ILE A CG1 1 
ATOM   4157 C  CG2 . ILE A 1 520 ? 7.827  -21.18  -4.013  1    29.27  ? 519  ILE A CG2 1 
ATOM   4158 C  CD1 . ILE A 1 520 ? 8.525  -22.842 -6.438  1    30.57  ? 519  ILE A CD1 1 
ATOM   4159 N  N   . GLU A 1 521 ? 4.942  -19.37  -3.095  1    30.09  ? 520  GLU A N   1 
ATOM   4160 C  CA  . GLU A 1 521 ? 4.814  -18.187 -2.246  1    31.66  ? 520  GLU A CA  1 
ATOM   4161 C  C   . GLU A 1 521 ? 6.119  -17.867 -1.56   1    31.11  ? 520  GLU A C   1 
ATOM   4162 O  O   . GLU A 1 521 ? 6.927  -18.776 -1.329  1    30.84  ? 520  GLU A O   1 
ATOM   4163 C  CB  . GLU A 1 521 ? 3.72   -18.418 -1.197  1    35.57  ? 520  GLU A CB  1 
ATOM   4164 C  CG  . GLU A 1 521 ? 2.335  -18.275 -1.791  1    42.74  ? 520  GLU A CG  1 
ATOM   4165 C  CD  . GLU A 1 521 ? 1.249  -18.612 -0.794  1    54.45  ? 520  GLU A CD  1 
ATOM   4166 O  OE1 . GLU A 1 521 ? 0.568  -17.675 -0.321  1    58.33  ? 520  GLU A OE1 1 
ATOM   4167 O  OE2 . GLU A 1 521 ? 1.094  -19.812 -0.469  1    57.72  ? 520  GLU A OE2 1 
ATOM   4168 N  N   . ASP A 1 522 ? 6.324  -16.58  -1.209  1    31.14  ? 521  ASP A N   1 
ATOM   4169 C  CA  . ASP A 1 522 ? 7.513  -16.095 -0.498  1    32.08  ? 521  ASP A CA  1 
ATOM   4170 C  C   . ASP A 1 522 ? 8.804  -16.485 -1.24   1    31.46  ? 521  ASP A C   1 
ATOM   4171 O  O   . ASP A 1 522 ? 9.834  -16.745 -0.623  1    32.29  ? 521  ASP A O   1 
ATOM   4172 C  CB  . ASP A 1 522 ? 7.536  -16.598 0.968   1    36.12  ? 521  ASP A CB  1 
ATOM   4173 C  CG  . ASP A 1 522 ? 8.471  -15.816 1.886   1    47.53  ? 521  ASP A CG  1 
ATOM   4174 O  OD1 . ASP A 1 522 ? 8.857  -14.681 1.518   1    49.78  ? 521  ASP A OD1 1 
ATOM   4175 O  OD2 . ASP A 1 522 ? 8.836  -16.351 2.967   1    52.37  ? 521  ASP A OD2 1 
ATOM   4176 N  N   . CYS A 1 523 ? 8.73   -16.496 -2.563  1    29.86  ? 522  CYS A N   1 
ATOM   4177 C  CA  . CYS A 1 523 ? 9.849  -16.858 -3.404  1    28.7   ? 522  CYS A CA  1 
ATOM   4178 C  C   . CYS A 1 523 ? 10.265 -15.694 -4.29   1    27.69  ? 522  CYS A C   1 
ATOM   4179 O  O   . CYS A 1 523 ? 9.425  -15.116 -4.99   1    28.03  ? 522  CYS A O   1 
ATOM   4180 C  CB  . CYS A 1 523 ? 9.462  -18.062 -4.242  1    28.89  ? 522  CYS A CB  1 
ATOM   4181 S  SG  . CYS A 1 523 ? 10.848 -18.722 -5.19   1    31.21  ? 522  CYS A SG  1 
ATOM   4182 N  N   . GLY A 1 524 ? 11.548 -15.37  -4.283  1    26.51  ? 523  GLY A N   1 
ATOM   4183 C  CA  . GLY A 1 524 ? 12.085 -14.292 -5.103  1    26.03  ? 523  GLY A CA  1 
ATOM   4184 C  C   . GLY A 1 524 ? 12.501 -14.785 -6.489  1    25.54  ? 523  GLY A C   1 
ATOM   4185 O  O   . GLY A 1 524 ? 11.937 -15.755 -6.994  1    27.19  ? 523  GLY A O   1 
ATOM   4186 N  N   . HIS A 1 525 ? 13.443 -14.088 -7.119  1    24.25  ? 524  HIS A N   1 
ATOM   4187 C  CA  . HIS A 1 525 ? 13.887 -14.42  -8.479  1    23.34  ? 524  HIS A CA  1 
ATOM   4188 C  C   . HIS A 1 525 ? 14.662 -15.725 -8.538  1    24.03  ? 524  HIS A C   1 
ATOM   4189 O  O   . HIS A 1 525 ? 14.567 -16.418 -9.557  1    23.7   ? 524  HIS A O   1 
ATOM   4190 C  CB  . HIS A 1 525 ? 14.761 -13.286 -9.054  1    23.89  ? 524  HIS A CB  1 
ATOM   4191 C  CG  . HIS A 1 525 ? 15.226 -13.554 -10.46  1    24.11  ? 524  HIS A CG  1 
ATOM   4192 N  ND1 . HIS A 1 525 ? 14.337 -13.514 -11.525 1    26.31  ? 524  HIS A ND1 1 
ATOM   4193 C  CD2 . HIS A 1 525 ? 16.455 -13.91  -10.924 1    25.22  ? 524  HIS A CD2 1 
ATOM   4194 C  CE1 . HIS A 1 525 ? 15.046 -13.845 -12.603 1    26.94  ? 524  HIS A CE1 1 
ATOM   4195 N  NE2 . HIS A 1 525 ? 16.33  -14.061 -12.297 1    25.76  ? 524  HIS A NE2 1 
ATOM   4196 N  N   . TRP A 1 526 ? 15.458 -16.057 -7.492  1    23.96  ? 525  TRP A N   1 
ATOM   4197 C  CA  . TRP A 1 526 ? 16.393 -17.221 -7.543  1    24.28  ? 525  TRP A CA  1 
ATOM   4198 C  C   . TRP A 1 526 ? 15.692 -18.48  -7.08   1    24.69  ? 525  TRP A C   1 
ATOM   4199 O  O   . TRP A 1 526 ? 16.083 -19.118 -6.109  1    24.98  ? 525  TRP A O   1 
ATOM   4200 C  CB  . TRP A 1 526 ? 17.692 -16.895 -6.766  1    24.45  ? 525  TRP A CB  1 
ATOM   4201 C  CG  . TRP A 1 526 ? 18.211 -15.51  -7.069  1    25.13  ? 525  TRP A CG  1 
ATOM   4202 C  CD1 . TRP A 1 526 ? 17.983 -14.376 -6.342  1    26.68  ? 525  TRP A CD1 1 
ATOM   4203 C  CD2 . TRP A 1 526 ? 18.847 -15.085 -8.283  1    25.74  ? 525  TRP A CD2 1 
ATOM   4204 N  NE1 . TRP A 1 526 ? 18.498 -13.276 -6.999  1    27.36  ? 525  TRP A NE1 1 
ATOM   4205 C  CE2 . TRP A 1 526 ? 19.078 -13.691 -8.173  1    26.93  ? 525  TRP A CE2 1 
ATOM   4206 C  CE3 . TRP A 1 526 ? 19.292 -15.753 -9.437  1    26.18  ? 525  TRP A CE3 1 
ATOM   4207 C  CZ2 . TRP A 1 526 ? 19.715 -12.958 -9.177  1    27.29  ? 525  TRP A CZ2 1 
ATOM   4208 C  CZ3 . TRP A 1 526 ? 19.944 -15.033 -10.41  1    27.34  ? 525  TRP A CZ3 1 
ATOM   4209 C  CH2 . TRP A 1 526 ? 20.14  -13.648 -10.289 1    27.97  ? 525  TRP A CH2 1 
ATOM   4210 N  N   . THR A 1 527 ? 14.606 -18.822 -7.799  1    24.17  ? 526  THR A N   1 
ATOM   4211 C  CA  . THR A 1 527 ? 13.658 -19.868 -7.471  1    24.79  ? 526  THR A CA  1 
ATOM   4212 C  C   . THR A 1 527 ? 14.267 -21.178 -6.991  1    24.9   ? 526  THR A C   1 
ATOM   4213 O  O   . THR A 1 527 ? 13.901 -21.67  -5.931  1    25.34  ? 526  THR A O   1 
ATOM   4214 C  CB  . THR A 1 527 ? 12.703 -20.099 -8.659  1    26.92  ? 526  THR A CB  1 
ATOM   4215 O  OG1 . THR A 1 527 ? 12.247 -18.818 -9.104  1    27.51  ? 526  THR A OG1 1 
ATOM   4216 C  CG2 . THR A 1 527 ? 11.521 -20.961 -8.28   1    28.65  ? 526  THR A CG2 1 
ATOM   4217 N  N   . GLN A 1 528 ? 15.231 -21.735 -7.751  1    24.13  ? 527  GLN A N   1 
ATOM   4218 C  CA  . GLN A 1 528 ? 15.81  -23.017 -7.419  1    23.95  ? 527  GLN A CA  1 
ATOM   4219 C  C   . GLN A 1 528 ? 16.482 -23.058 -6.076  1    25.1   ? 527  GLN A C   1 
ATOM   4220 O  O   . GLN A 1 528 ? 16.407 -24.081 -5.41   1    26     ? 527  GLN A O   1 
ATOM   4221 C  CB  . GLN A 1 528 ? 16.804 -23.48  -8.515  1    24.11  ? 527  GLN A CB  1 
ATOM   4222 C  CG  . GLN A 1 528 ? 16.168 -23.45  -9.891  1    24.77  ? 527  GLN A CG  1 
ATOM   4223 C  CD  . GLN A 1 528 ? 16.684 -22.265 -10.622 1    27.43  ? 527  GLN A CD  1 
ATOM   4224 O  OE1 . GLN A 1 528 ? 16.446 -21.114 -10.224 1    26.61  ? 527  GLN A OE1 1 
ATOM   4225 N  NE2 . GLN A 1 528 ? 17.402 -22.508 -11.731 1    26.21  ? 527  GLN A NE2 1 
ATOM   4226 N  N   . MET A 1 529 ? 17.192 -21.994 -5.704  1    26.03  ? 528  MET A N   1 
ATOM   4227 C  CA  . MET A 1 529 ? 17.879 -21.98  -4.404  1    27.73  ? 528  MET A CA  1 
ATOM   4228 C  C   . MET A 1 529 ? 17.069 -21.317 -3.301  1    27.97  ? 528  MET A C   1 
ATOM   4229 O  O   . MET A 1 529 ? 17.395 -21.494 -2.132  1    28.24  ? 528  MET A O   1 
ATOM   4230 C  CB  . MET A 1 529 ? 19.266 -21.355 -4.503  1    29.11  ? 528  MET A CB  1 
ATOM   4231 C  CG  . MET A 1 529 ? 19.272 -19.957 -5.017  1    32.14  ? 528  MET A CG  1 
ATOM   4232 S  SD  . MET A 1 529 ? 20.961 -19.304 -4.867  1    39.74  ? 528  MET A SD  1 
ATOM   4233 C  CE  . MET A 1 529 ? 21.132 -18.483 -6.417  1    37.74  ? 528  MET A CE  1 
ATOM   4234 N  N   . ASP A 1 530 ? 16.03  -20.554 -3.655  1    27.07  ? 529  ASP A N   1 
ATOM   4235 C  CA  . ASP A 1 530 ? 15.201 -19.892 -2.652  1    27.26  ? 529  ASP A CA  1 
ATOM   4236 C  C   . ASP A 1 530 ? 14.275 -20.924 -2.015  1    26.67  ? 529  ASP A C   1 
ATOM   4237 O  O   . ASP A 1 530 ? 14.208 -21.012 -0.778  1    28.4   ? 529  ASP A O   1 
ATOM   4238 C  CB  . ASP A 1 530 ? 14.423 -18.744 -3.318  1    27.72  ? 529  ASP A CB  1 
ATOM   4239 C  CG  . ASP A 1 530 ? 13.76  -17.758 -2.371  1    31.07  ? 529  ASP A CG  1 
ATOM   4240 O  OD1 . ASP A 1 530 ? 13.397 -18.171 -1.237  1    30.58  ? 529  ASP A OD1 1 
ATOM   4241 O  OD2 . ASP A 1 530 ? 13.584 -16.571 -2.774  1    29.5   ? 529  ASP A OD2 1 
ATOM   4242 N  N   . LYS A 1 531 ? 13.53  -21.675 -2.842  1    25.15  ? 530  LYS A N   1 
ATOM   4243 C  CA  . LYS A 1 531 ? 12.571 -22.688 -2.389  1    24.98  ? 530  LYS A CA  1 
ATOM   4244 C  C   . LYS A 1 531 ? 12.84  -24.024 -3.11   1    24.49  ? 530  LYS A C   1 
ATOM   4245 O  O   . LYS A 1 531 ? 11.98  -24.532 -3.839  1    24.38  ? 530  LYS A O   1 
ATOM   4246 C  CB  . LYS A 1 531 ? 11.148 -22.196 -2.707  1    26.95  ? 530  LYS A CB  1 
ATOM   4247 C  CG  . LYS A 1 531 ? 10.791 -20.933 -1.936  1    30.84  ? 530  LYS A CG  1 
ATOM   4248 C  CD  . LYS A 1 531 ? 10.46  -21.309 -0.497  1    33.74  ? 530  LYS A CD  1 
ATOM   4249 C  CE  . LYS A 1 531 ? 10.121 -20.07  0.283   1    35.75  ? 530  LYS A CE  1 
ATOM   4250 N  NZ  . LYS A 1 531 ? 11.342 -19.313 0.617   1    37.26  ? 530  LYS A NZ  1 
ATOM   4251 N  N   . PRO A 1 532 ? 13.991 -24.659 -2.839  1    24.52  ? 531  PRO A N   1 
ATOM   4252 C  CA  . PRO A 1 532 ? 14.321 -25.908 -3.564  1    24.44  ? 531  PRO A CA  1 
ATOM   4253 C  C   . PRO A 1 532 ? 13.366 -27.068 -3.312  1    24.5   ? 531  PRO A C   1 
ATOM   4254 O  O   . PRO A 1 532 ? 13.044 -27.806 -4.238  1    23.92  ? 531  PRO A O   1 
ATOM   4255 C  CB  . PRO A 1 532 ? 15.76  -26.215 -3.118  1    25.04  ? 531  PRO A CB  1 
ATOM   4256 C  CG  . PRO A 1 532 ? 15.963 -25.428 -1.853  1    25.57  ? 531  PRO A CG  1 
ATOM   4257 C  CD  . PRO A 1 532 ? 15.127 -24.197 -2.016  1    23.92  ? 531  PRO A CD  1 
ATOM   4258 N  N   . THR A 1 533 ? 12.882 -27.224 -2.066  1    25.35  ? 532  THR A N   1 
ATOM   4259 C  CA  . THR A 1 533 ? 11.962 -28.316 -1.738  1    26.48  ? 532  THR A CA  1 
ATOM   4260 C  C   . THR A 1 533 ? 10.682 -28.171 -2.546  1    25.61  ? 532  THR A C   1 
ATOM   4261 O  O   . THR A 1 533 ? 10.204 -29.138 -3.108  1    26     ? 532  THR A O   1 
ATOM   4262 C  CB  . THR A 1 533 ? 11.64  -28.295 -0.207  1    29.25  ? 532  THR A CB  1 
ATOM   4263 O  OG1 . THR A 1 533 ? 12.851 -28.466 0.516   1    31.2   ? 532  THR A OG1 1 
ATOM   4264 C  CG2 . THR A 1 533 ? 10.655 -29.387 0.195   1    30.04  ? 532  THR A CG2 1 
ATOM   4265 N  N   . GLU A 1 534 ? 10.151 -26.95  -2.62   1    24.7   ? 533  GLU A N   1 
ATOM   4266 C  CA  . GLU A 1 534 ? 8.928  -26.662 -3.35   1    25.67  ? 533  GLU A CA  1 
ATOM   4267 C  C   . GLU A 1 534 ? 9.103  -26.853 -4.857  1    25.11  ? 533  GLU A C   1 
ATOM   4268 O  O   . GLU A 1 534 ? 8.249  -27.441 -5.496  1    25.01  ? 533  GLU A O   1 
ATOM   4269 C  CB  . GLU A 1 534 ? 8.458  -25.242 -3.009  1    29     ? 533  GLU A CB  1 
ATOM   4270 C  CG  . GLU A 1 534 ? 8.085  -25.087 -1.532  1    37.92  ? 533  GLU A CG  1 
ATOM   4271 C  CD  . GLU A 1 534 ? 9.183  -24.827 -0.504  1    47.22  ? 533  GLU A CD  1 
ATOM   4272 O  OE1 . GLU A 1 534 ? 10.382 -24.772 -0.877  1    45.85  ? 533  GLU A OE1 1 
ATOM   4273 O  OE2 . GLU A 1 534 ? 8.835  -24.69  0.693   1    50.83  ? 533  GLU A OE2 1 
ATOM   4274 N  N   . VAL A 1 535 ? 10.218 -26.378 -5.418  1    24.6   ? 534  VAL A N   1 
ATOM   4275 C  CA  . VAL A 1 535 ? 10.532 -26.554 -6.85   1    23.76  ? 534  VAL A CA  1 
ATOM   4276 C  C   . VAL A 1 535 ? 10.579 -28.042 -7.196  1    22.74  ? 534  VAL A C   1 
ATOM   4277 O  O   . VAL A 1 535 ? 9.981  -28.458 -8.18   1    22.86  ? 534  VAL A O   1 
ATOM   4278 C  CB  . VAL A 1 535 ? 11.881 -25.85  -7.211  1    24.06  ? 534  VAL A CB  1 
ATOM   4279 C  CG1 . VAL A 1 535 ? 12.374 -26.274 -8.595  1    25.25  ? 534  VAL A CG1 1 
ATOM   4280 C  CG2 . VAL A 1 535 ? 11.724 -24.342 -7.144  1    23.92  ? 534  VAL A CG2 1 
ATOM   4281 N  N   . ASN A 1 536 ? 11.287 -28.842 -6.382  1    22.73  ? 535  ASN A N   1 
ATOM   4282 C  CA  . ASN A 1 536 ? 11.426 -30.271 -6.623  1    23.73  ? 535  ASN A CA  1 
ATOM   4283 C  C   . ASN A 1 536 ? 10.067 -30.96  -6.608  1    24.92  ? 535  ASN A C   1 
ATOM   4284 O  O   . ASN A 1 536 ? 9.755  -31.713 -7.518  1    24.63  ? 535  ASN A O   1 
ATOM   4285 C  CB  . ASN A 1 536 ? 12.339 -30.887 -5.567  1    23.79  ? 535  ASN A CB  1 
ATOM   4286 C  CG  . ASN A 1 536 ? 13.797 -30.477 -5.703  1    24.49  ? 535  ASN A CG  1 
ATOM   4287 O  OD1 . ASN A 1 536 ? 14.17  -29.727 -6.611  1    25.61  ? 535  ASN A OD1 1 
ATOM   4288 N  ND2 . ASN A 1 536 ? 14.63  -30.921 -4.792  1    23.5   ? 535  ASN A ND2 1 
ATOM   4289 N  N   . GLN A 1 537 ? 9.219  -30.61  -5.615  1    25.87  ? 536  GLN A N   1 
ATOM   4290 C  CA  . GLN A 1 537 ? 7.879  -31.197 -5.534  1    26.31  ? 536  GLN A CA  1 
ATOM   4291 C  C   . GLN A 1 537 ? 7.053  -30.879 -6.813  1    24.87  ? 536  GLN A C   1 
ATOM   4292 O  O   . GLN A 1 537 ? 6.472  -31.784 -7.407  1    24.5   ? 536  GLN A O   1 
ATOM   4293 C  CB  . GLN A 1 537 ? 7.157  -30.696 -4.263  1    29.3   ? 536  GLN A CB  1 
ATOM   4294 C  CG  . GLN A 1 537 ? 5.687  -31.098 -4.194  1    37.56  ? 536  GLN A CG  1 
ATOM   4295 C  CD  . GLN A 1 537 ? 4.753  -29.933 -4.487  1    47.45  ? 536  GLN A CD  1 
ATOM   4296 O  OE1 . GLN A 1 537 ? 4.888  -28.823 -3.929  1    50.86  ? 536  GLN A OE1 1 
ATOM   4297 N  NE2 . GLN A 1 537 ? 3.786  -30.159 -5.371  1    48.82  ? 536  GLN A NE2 1 
ATOM   4298 N  N   . ILE A 1 538 ? 7.055  -29.621 -7.239  1    23.83  ? 537  ILE A N   1 
ATOM   4299 C  CA  . ILE A 1 538 ? 6.292  -29.185 -8.404  1    23.33  ? 537  ILE A CA  1 
ATOM   4300 C  C   . ILE A 1 538 ? 6.807  -29.868 -9.685  1    23.58  ? 537  ILE A C   1 
ATOM   4301 O  O   . ILE A 1 538 ? 6.009  -30.373 -10.478 1    23.02  ? 537  ILE A O   1 
ATOM   4302 C  CB  . ILE A 1 538 ? 6.352  -27.639 -8.512  1    24.06  ? 537  ILE A CB  1 
ATOM   4303 C  CG1 . ILE A 1 538 ? 5.503  -26.966 -7.403  1    25.19  ? 537  ILE A CG1 1 
ATOM   4304 C  CG2 . ILE A 1 538 ? 5.916  -27.151 -9.881  1    24.78  ? 537  ILE A CG2 1 
ATOM   4305 C  CD1 . ILE A 1 538 ? 5.867  -25.523 -7.237  1    27.63  ? 537  ILE A CD1 1 
ATOM   4306 N  N   . LEU A 1 539 ? 8.136  -29.861 -9.875  1    22.53  ? 538  LEU A N   1 
ATOM   4307 C  CA  . LEU A 1 539 ? 8.695  -30.466 -11.084 1    22.67  ? 538  LEU A CA  1 
ATOM   4308 C  C   . LEU A 1 539 ? 8.488  -31.942 -11.149 1    23.76  ? 538  LEU A C   1 
ATOM   4309 O  O   . LEU A 1 539 ? 8.148  -32.432 -12.22  1    24.35  ? 538  LEU A O   1 
ATOM   4310 C  CB  . LEU A 1 539 ? 10.185 -30.141 -11.255 1    22.83  ? 538  LEU A CB  1 
ATOM   4311 C  CG  . LEU A 1 539 ? 10.525 -28.643 -11.407 1    23.71  ? 538  LEU A CG  1 
ATOM   4312 C  CD1 . LEU A 1 539 ? 12.038 -28.481 -11.559 1    25.17  ? 538  LEU A CD1 1 
ATOM   4313 C  CD2 . LEU A 1 539 ? 9.832  -28.028 -12.612 1    24.02  ? 538  LEU A CD2 1 
ATOM   4314 N  N   . ILE A 1 540 ? 8.711  -32.676 -10.039 1    23.03  ? 539  ILE A N   1 
ATOM   4315 C  CA  . ILE A 1 540 ? 8.569  -34.139 -10.083 1    24.28  ? 539  ILE A CA  1 
ATOM   4316 C  C   . ILE A 1 540 ? 7.101  -34.53  -10.308 1    25.15  ? 539  ILE A C   1 
ATOM   4317 O  O   . ILE A 1 540 ? 6.816  -35.414 -11.113 1    25.33  ? 539  ILE A O   1 
ATOM   4318 C  CB  . ILE A 1 540 ? 9.179  -34.757 -8.812  1    24.85  ? 539  ILE A CB  1 
ATOM   4319 C  CG1 . ILE A 1 540 ? 10.709 -34.646 -8.859  1    25.81  ? 539  ILE A CG1 1 
ATOM   4320 C  CG2 . ILE A 1 540 ? 8.762  -36.237 -8.657  1    25.65  ? 539  ILE A CG2 1 
ATOM   4321 C  CD1 . ILE A 1 540 ? 11.341 -34.895 -7.556  1    26.96  ? 539  ILE A CD1 1 
ATOM   4322 N  N   . LYS A 1 541 ? 6.168  -33.821 -9.653  1    25     ? 540  LYS A N   1 
ATOM   4323 C  CA  . LYS A 1 541 ? 4.739  -34.093 -9.871  1    25.21  ? 540  LYS A CA  1 
ATOM   4324 C  C   . LYS A 1 541 ? 4.353  -33.899 -11.351 1    25.52  ? 540  LYS A C   1 
ATOM   4325 O  O   . LYS A 1 541 ? 3.685  -34.752 -11.95  1    25.71  ? 540  LYS A O   1 
ATOM   4326 C  CB  . LYS A 1 541 ? 3.888  -33.19  -8.965  1    27.17  ? 540  LYS A CB  1 
ATOM   4327 C  CG  . LYS A 1 541 ? 2.39   -33.361 -9.191  1    32.85  ? 540  LYS A CG  1 
ATOM   4328 C  CD  . LYS A 1 541 ? 1.591  -32.247 -8.513  1    38.05  ? 540  LYS A CD  1 
ATOM   4329 C  CE  . LYS A 1 541 ? 0.178  -32.207 -9.058  1    43.36  ? 540  LYS A CE  1 
ATOM   4330 N  NZ  . LYS A 1 541 ? -0.646 -31.21  -8.319  1    45.43  ? 540  LYS A NZ  1 
ATOM   4331 N  N   . TRP A 1 542 ? 4.84   -32.816 -11.965 1    25.22  ? 541  TRP A N   1 
ATOM   4332 C  CA  . TRP A 1 542 ? 4.548  -32.531 -13.364 1    25.29  ? 541  TRP A CA  1 
ATOM   4333 C  C   . TRP A 1 542 ? 5.217  -33.529 -14.325 1    25     ? 541  TRP A C   1 
ATOM   4334 O  O   . TRP A 1 542 ? 4.574  -34.03  -15.251 1    25.15  ? 541  TRP A O   1 
ATOM   4335 C  CB  . TRP A 1 542 ? 4.964  -31.083 -13.687 1    24.65  ? 541  TRP A CB  1 
ATOM   4336 C  CG  . TRP A 1 542 ? 4.837  -30.756 -15.136 1    24.81  ? 541  TRP A CG  1 
ATOM   4337 C  CD1 . TRP A 1 542 ? 3.686  -30.633 -15.857 1    25.93  ? 541  TRP A CD1 1 
ATOM   4338 C  CD2 . TRP A 1 542 ? 5.918  -30.639 -16.074 1    24.53  ? 541  TRP A CD2 1 
ATOM   4339 N  NE1 . TRP A 1 542 ? 3.983  -30.344 -17.172 1    26.34  ? 541  TRP A NE1 1 
ATOM   4340 C  CE2 . TRP A 1 542 ? 5.349  -30.361 -17.336 1    25.37  ? 541  TRP A CE2 1 
ATOM   4341 C  CE3 . TRP A 1 542 ? 7.313  -30.701 -15.955 1    24.19  ? 541  TRP A CE3 1 
ATOM   4342 C  CZ2 . TRP A 1 542 ? 6.127  -30.094 -18.465 1    25.81  ? 541  TRP A CZ2 1 
ATOM   4343 C  CZ3 . TRP A 1 542 ? 8.088  -30.495 -17.098 1    24.81  ? 541  TRP A CZ3 1 
ATOM   4344 C  CH2 . TRP A 1 542 ? 7.497  -30.172 -18.323 1    25.38  ? 541  TRP A CH2 1 
ATOM   4345 N  N   . LEU A 1 543 ? 6.497  -33.844 -14.102 1    23.88  ? 542  LEU A N   1 
ATOM   4346 C  CA  . LEU A 1 543 ? 7.213  -34.805 -14.943 1    24.23  ? 542  LEU A CA  1 
ATOM   4347 C  C   . LEU A 1 543 ? 6.524  -36.178 -14.893 1    26.18  ? 542  LEU A C   1 
ATOM   4348 O  O   . LEU A 1 543 ? 6.321  -36.791 -15.939 1    27.75  ? 542  LEU A O   1 
ATOM   4349 C  CB  . LEU A 1 543 ? 8.657  -34.954 -14.456 1    23.57  ? 542  LEU A CB  1 
ATOM   4350 C  CG  . LEU A 1 543 ? 9.593  -33.782 -14.802 1    23.51  ? 542  LEU A CG  1 
ATOM   4351 C  CD1 . LEU A 1 543 ? 10.872 -33.887 -13.988 1    23.91  ? 542  LEU A CD1 1 
ATOM   4352 C  CD2 . LEU A 1 543 ? 9.852  -33.717 -16.329 1    23.72  ? 542  LEU A CD2 1 
ATOM   4353 N  N   . ASP A 1 544 ? 6.168  -36.646 -13.697 1    27.36  ? 543  ASP A N   1 
ATOM   4354 C  CA  . ASP A 1 544 ? 5.538  -37.966 -13.558 1    28.31  ? 543  ASP A CA  1 
ATOM   4355 C  C   . ASP A 1 544 ? 4.165  -38.076 -14.249 1    30.57  ? 543  ASP A C   1 
ATOM   4356 O  O   . ASP A 1 544 ? 3.844  -39.144 -14.774 1    31.01  ? 543  ASP A O   1 
ATOM   4357 C  CB  . ASP A 1 544 ? 5.464  -38.393 -12.091 1    28.97  ? 543  ASP A CB  1 
ATOM   4358 C  CG  . ASP A 1 544 ? 6.795  -38.848 -11.504 1    33.74  ? 543  ASP A CG  1 
ATOM   4359 O  OD1 . ASP A 1 544 ? 7.781  -38.998 -12.279 1    35.95  ? 543  ASP A OD1 1 
ATOM   4360 O  OD2 . ASP A 1 544 ? 6.851  -39.066 -10.292 1    35.04  ? 543  ASP A OD2 1 
ATOM   4361 N  N   . SER A 1 545 ? 3.407  -36.978 -14.319 1    31.36  ? 544  SER A N   1 
ATOM   4362 C  CA  . SER A 1 545 ? 2.102  -37.023 -14.968 1    34.34  ? 544  SER A CA  1 
ATOM   4363 C  C   . SER A 1 545 ? 2.126  -36.662 -16.447 1    35.98  ? 544  SER A C   1 
ATOM   4364 O  O   . SER A 1 545 ? 1.313  -37.183 -17.205 1    36     ? 544  SER A O   1 
ATOM   4365 C  CB  . SER A 1 545 ? 1.093  -36.149 -14.226 1    36.38  ? 544  SER A CB  1 
ATOM   4366 O  OG  . SER A 1 545 ? 1.426  -34.77  -14.31  1    39.38  ? 544  SER A OG  1 
ATOM   4367 N  N   . ASP A 1 546 ? 3.054  -35.782 -16.871 1    36.8   ? 545  ASP A N   1 
ATOM   4368 C  CA  . ASP A 1 546 ? 3.064  -35.287 -18.244 1    37.94  ? 545  ASP A CA  1 
ATOM   4369 C  C   . ASP A 1 546 ? 4.287  -35.579 -19.105 1    38.73  ? 545  ASP A C   1 
ATOM   4370 O  O   . ASP A 1 546 ? 4.221  -35.334 -20.313 1    38.24  ? 545  ASP A O   1 
ATOM   4371 C  CB  . ASP A 1 546 ? 2.84   -33.778 -18.233 1    40.33  ? 545  ASP A CB  1 
ATOM   4372 C  CG  . ASP A 1 546 ? 1.429  -33.394 -17.831 1    47.1   ? 545  ASP A CG  1 
ATOM   4373 O  OD1 . ASP A 1 546 ? 1.107  -33.496 -16.632 1    48.21  ? 545  ASP A OD1 1 
ATOM   4374 O  OD2 . ASP A 1 546 ? 0.656  -32.968 -18.715 1    49.96  ? 545  ASP A OD2 1 
ATOM   4375 N  N   . ALA A 1 547 ? 5.396  -36.048 -18.522 1    39.73  ? 546  ALA A N   1 
ATOM   4376 C  CA  . ALA A 1 547 ? 6.616  -36.27  -19.297 1    42.25  ? 546  ALA A CA  1 
ATOM   4377 C  C   . ALA A 1 547 ? 7.072  -37.722 -19.418 1    45.27  ? 546  ALA A C   1 
ATOM   4378 O  O   . ALA A 1 547 ? 8.127  -37.97  -20.009 1    46.32  ? 546  ALA A O   1 
ATOM   4379 C  CB  . ALA A 1 547 ? 7.745  -35.425 -18.738 1    42.38  ? 546  ALA A CB  1 
ATOM   4380 N  N   A ARG A 1 548 ? 6.279  -38.683 -18.92  0.5  46.13  ? 547  ARG A N   1 
ATOM   4381 N  N   B ARG A 1 548 ? 6.325  -38.672 -18.839 0.5  45.41  ? 547  ARG A N   1 
ATOM   4382 C  CA  A ARG A 1 548 ? 6.645  -40.098 -19.044 0.5  47.37  ? 547  ARG A CA  1 
ATOM   4383 C  CA  B ARG A 1 548 ? 6.718  -40.082 -18.904 0.5  45.92  ? 547  ARG A CA  1 
ATOM   4384 C  C   A ARG A 1 548 ? 5.913  -40.754 -20.211 0.5  48.34  ? 547  ARG A C   1 
ATOM   4385 C  C   B ARG A 1 548 ? 6.41   -40.715 -20.254 0.5  46.73  ? 547  ARG A C   1 
ATOM   4386 O  O   A ARG A 1 548 ? 5.559  -41.931 -20.139 0.5  48.89  ? 547  ARG A O   1 
ATOM   4387 O  O   B ARG A 1 548 ? 7.257  -41.421 -20.8   0.5  47.05  ? 547  ARG A O   1 
ATOM   4388 C  CB  A ARG A 1 548 ? 6.382  -40.865 -17.742 0.5  48.59  ? 547  ARG A CB  1 
ATOM   4389 C  CB  B ARG A 1 548 ? 6.076  -40.888 -17.771 0.5  46.24  ? 547  ARG A CB  1 
ATOM   4390 C  CG  A ARG A 1 548 ? 7.248  -40.401 -16.587 0.5  50.22  ? 547  ARG A CG  1 
ATOM   4391 C  CG  B ARG A 1 548 ? 6.666  -40.57  -16.412 0.5  45.88  ? 547  ARG A CG  1 
ATOM   4392 C  CD  A ARG A 1 548 ? 7.147  -41.324 -15.379 0.5  51.68  ? 547  ARG A CD  1 
ATOM   4393 C  CD  B ARG A 1 548 ? 8.07   -41.126 -16.244 0.5  44.63  ? 547  ARG A CD  1 
ATOM   4394 N  NE  A ARG A 1 548 ? 5.781  -41.434 -14.864 0.5  52.25  ? 547  ARG A NE  1 
ATOM   4395 N  NE  B ARG A 1 548 ? 8.445  -41.142 -14.83  0.5  41.91  ? 547  ARG A NE  1 
ATOM   4396 C  CZ  A ARG A 1 548 ? 5.463  -41.955 -13.684 0.5  53.25  ? 547  ARG A CZ  1 
ATOM   4397 C  CZ  B ARG A 1 548 ? 9.643  -41.483 -14.367 0.5  37.82  ? 547  ARG A CZ  1 
ATOM   4398 N  NH1 A ARG A 1 548 ? 6.412  -42.399 -12.868 0.5  52.11  ? 547  ARG A NH1 1 
ATOM   4399 N  NH1 B ARG A 1 548 ? 10.611 -41.833 -15.206 0.5  32.99  ? 547  ARG A NH1 1 
ATOM   4400 N  NH2 A ARG A 1 548 ? 4.195  -42.021 -13.302 0.5  53     ? 547  ARG A NH2 1 
ATOM   4401 N  NH2 B ARG A 1 548 ? 9.887  -41.459 -13.063 0.5  34.59  ? 547  ARG A NH2 1 
HETATM 4402 C  C1  . GOL B 2 .   ? 36.841 -10.192 -19.579 1    60.09  ? 601  GOL A C1  1 
HETATM 4403 O  O1  . GOL B 2 .   ? 36.681 -8.778  -19.617 1    59.82  ? 601  GOL A O1  1 
HETATM 4404 C  C2  . GOL B 2 .   ? 37.446 -10.727 -20.858 1    60.36  ? 601  GOL A C2  1 
HETATM 4405 O  O2  . GOL B 2 .   ? 37.151 -12.121 -20.998 1    60.67  ? 601  GOL A O2  1 
HETATM 4406 C  C3  . GOL B 2 .   ? 36.957 -9.995  -22.083 1    60.26  ? 601  GOL A C3  1 
HETATM 4407 O  O3  . GOL B 2 .   ? 35.564 -10.208 -22.262 1    59.91  ? 601  GOL A O3  1 
HETATM 4408 C  C1  . GOL C 2 .   ? 21.89  -72.339 -8.512  0.5  47.78  ? 602  GOL A C1  1 
HETATM 4409 O  O1  . GOL C 2 .   ? 20.473 -72.428 -8.541  0.5  47.87  ? 602  GOL A O1  1 
HETATM 4410 C  C2  . GOL C 2 .   ? 22.53  -73.642 -8.931  0.5  47.73  ? 602  GOL A C2  1 
HETATM 4411 O  O2  . GOL C 2 .   ? 22.41  -73.804 -10.349 0.5  47.93  ? 602  GOL A O2  1 
HETATM 4412 C  C3  . GOL C 2 .   ? 23.986 -73.733 -8.529  0.5  47.33  ? 602  GOL A C3  1 
HETATM 4413 O  O3  . GOL C 2 .   ? 24.176 -73.494 -7.143  0.5  46.96  ? 602  GOL A O3  1 
HETATM 4414 C  C1  . GOL D 2 .   ? 15.215 -11.422 -18.763 1    71.33  ? 603  GOL A C1  1 
HETATM 4415 O  O1  . GOL D 2 .   ? 14.985 -10.965 -17.436 1    71.57  ? 603  GOL A O1  1 
HETATM 4416 C  C2  . GOL D 2 .   ? 14.214 -12.487 -19.144 1    71.24  ? 603  GOL A C2  1 
HETATM 4417 O  O2  . GOL D 2 .   ? 14.313 -13.589 -18.241 1    71.13  ? 603  GOL A O2  1 
HETATM 4418 C  C3  . GOL D 2 .   ? 14.387 -12.964 -20.566 1    71.26  ? 603  GOL A C3  1 
HETATM 4419 O  O3  . GOL D 2 .   ? 14.081 -11.929 -21.487 1    71.29  ? 603  GOL A O3  1 
HETATM 4420 S  S   . SO4 E 3 .   ? 36.332 -26.572 -29.059 1    102.89 ? 604  SO4 A S   1 
HETATM 4421 O  O1  . SO4 E 3 .   ? 37.306 -26.303 -30.128 1    102.98 ? 604  SO4 A O1  1 
HETATM 4422 O  O2  . SO4 E 3 .   ? 35.296 -27.49  -29.549 1    102.88 ? 604  SO4 A O2  1 
HETATM 4423 O  O3  . SO4 E 3 .   ? 37.019 -27.213 -27.916 1    102.79 ? 604  SO4 A O3  1 
HETATM 4424 O  O4  . SO4 E 3 .   ? 35.732 -25.298 -28.607 1    102.81 ? 604  SO4 A O4  1 
HETATM 4425 NA NA  . NA  F 4 .   ? 17.24  4.922   -15.003 1    59.93  1 605  NA  A NA  1 
HETATM 4426 O  O   . HOH G 5 .   ? 30.752 -52.647 -0.24   1    43.23  ? 701  HOH A O   1 
HETATM 4427 O  O   . HOH G 5 .   ? 20.107 -41.8   -5.921  1    50.01  ? 702  HOH A O   1 
HETATM 4428 O  O   . HOH G 5 .   ? 24.799 6.306   -3.348  1    53.56  ? 703  HOH A O   1 
HETATM 4429 O  O   . HOH G 5 .   ? 25.652 -26.938 -2.026  1    50.04  ? 704  HOH A O   1 
HETATM 4430 O  O   . HOH G 5 .   ? 22.259 -22.779 -1.512  1    37.51  ? 705  HOH A O   1 
HETATM 4431 O  O   . HOH G 5 .   ? 17.706 -35.854 12.608  1    39.99  ? 706  HOH A O   1 
HETATM 4432 O  O   . HOH G 5 .   ? 3.894  -13.579 -38.111 1    55.52  ? 707  HOH A O   1 
HETATM 4433 O  O   . HOH G 5 .   ? 15.592 -45.432 -2.198  1    41.95  ? 708  HOH A O   1 
HETATM 4434 O  O   . HOH G 5 .   ? 7.841  -5.17   -29.115 1    42.24  ? 709  HOH A O   1 
HETATM 4435 O  O   . HOH G 5 .   ? 12.051 -50.846 -1.651  1    49.35  ? 710  HOH A O   1 
HETATM 4436 O  O   . HOH G 5 .   ? 29.049 -36.164 -3.393  1    45.63  ? 711  HOH A O   1 
HETATM 4437 O  O   . HOH G 5 .   ? 3.247  -42.774 -19.641 1    67.43  ? 712  HOH A O   1 
HETATM 4438 O  O   . HOH G 5 .   ? 20.587 -58.352 5.915   1    49.94  ? 713  HOH A O   1 
HETATM 4439 O  O   . HOH G 5 .   ? 34.431 -3.795  -5.155  1    56.14  ? 714  HOH A O   1 
HETATM 4440 O  O   . HOH G 5 .   ? 25.928 -64.425 11.228  1    40.91  ? 715  HOH A O   1 
HETATM 4441 O  O   . HOH G 5 .   ? 31.080 0.873   -24.963 1    54.02  ? 716  HOH A O   1 
HETATM 4442 O  O   . HOH G 5 .   ? 31.627 -21.744 -35.185 1    60.89  ? 717  HOH A O   1 
HETATM 4443 O  O   . HOH G 5 .   ? 0.103  -29.14  -20.589 1    37.75  ? 718  HOH A O   1 
HETATM 4444 O  O   . HOH G 5 .   ? 16.273 -56.093 -11.812 1    33.54  ? 719  HOH A O   1 
HETATM 4445 O  O   . HOH G 5 .   ? 33.859 -29.915 -5.765  1    55.56  ? 720  HOH A O   1 
HETATM 4446 O  O   . HOH G 5 .   ? 27.928 -28.133 -3.381  1    49.1   ? 721  HOH A O   1 
HETATM 4447 O  O   . HOH G 5 .   ? 36.412 -17.876 -22.673 1    37.19  ? 722  HOH A O   1 
HETATM 4448 O  O   . HOH G 5 .   ? 24.572 0.733   -27.181 1    57.3   ? 723  HOH A O   1 
HETATM 4449 O  O   . HOH G 5 .   ? 10.854 -77.986 13.63   1    53.6   ? 724  HOH A O   1 
HETATM 4450 O  O   . HOH G 5 .   ? 26.442 -2.659  -20.647 1    31.42  ? 725  HOH A O   1 
HETATM 4451 O  O   . HOH G 5 .   ? 18.077 -32.857 -4.393  1    25.78  ? 726  HOH A O   1 
HETATM 4452 O  O   . HOH G 5 .   ? 13.722 -51.528 13.884  1    38.61  ? 727  HOH A O   1 
HETATM 4453 O  O   . HOH G 5 .   ? 8.004  -60.377 12.171  1    46.75  ? 728  HOH A O   1 
HETATM 4454 O  O   . HOH G 5 .   ? 21.823 -73.926 -5.016  1    49.1   ? 729  HOH A O   1 
HETATM 4455 O  O   . HOH G 5 .   ? 36.721 -27.383 -19.129 1    41.31  ? 730  HOH A O   1 
HETATM 4456 O  O   . HOH G 5 .   ? 21.534 -25.043 -16.771 1    18.61  ? 731  HOH A O   1 
HETATM 4457 O  O   . HOH G 5 .   ? 21.188 -71.517 7.143   1    32.57  ? 732  HOH A O   1 
HETATM 4458 O  O   . HOH G 5 .   ? 19.888 -55.834 -5.486  1    35.69  ? 733  HOH A O   1 
HETATM 4459 O  O   . HOH G 5 .   ? -3.467 -23.448 -16.76  1    40.84  ? 734  HOH A O   1 
HETATM 4460 O  O   . HOH G 5 .   ? 11.183 -70.074 -4.425  1    43.13  ? 735  HOH A O   1 
HETATM 4461 O  O   . HOH G 5 .   ? 33.956 -45.18  1.194   1    56.46  ? 736  HOH A O   1 
HETATM 4462 O  O   . HOH G 5 .   ? 39.315 -25.017 -31.158 1    66.36  ? 737  HOH A O   1 
HETATM 4463 O  O   . HOH G 5 .   ? 34.976 -59.663 -2.361  1    46     ? 738  HOH A O   1 
HETATM 4464 O  O   . HOH G 5 .   ? 11.166 -75.373 13.685  1    55.14  ? 739  HOH A O   1 
HETATM 4465 O  O   . HOH G 5 .   ? 26.116 -63.66  -1.31   1    25.29  ? 740  HOH A O   1 
HETATM 4466 O  O   . HOH G 5 .   ? 33.711 -36.443 -11.406 1    27.59  ? 741  HOH A O   1 
HETATM 4467 O  O   . HOH G 5 .   ? 16.039 -38.391 3.007   1    38.75  ? 742  HOH A O   1 
HETATM 4468 O  O   . HOH G 5 .   ? 16.688 -48.018 21.15   1    31.88  ? 743  HOH A O   1 
HETATM 4469 O  O   . HOH G 5 .   ? 22.275 -38.23  -33.922 1    40.48  ? 744  HOH A O   1 
HETATM 4470 O  O   . HOH G 5 .   ? 26.446 -5.09   -2.323  1    52.55  ? 745  HOH A O   1 
HETATM 4471 O  O   . HOH G 5 .   ? 22.774 -5.109  -29.679 1    36.28  ? 746  HOH A O   1 
HETATM 4472 O  O   . HOH G 5 .   ? -0.142 -33.857 -21.036 1    46.62  ? 747  HOH A O   1 
HETATM 4473 O  O   . HOH G 5 .   ? 17.032 -70.072 -7.517  1    36.38  ? 748  HOH A O   1 
HETATM 4474 O  O   . HOH G 5 .   ? 5.083  -38.123 -8.613  1    50.87  ? 749  HOH A O   1 
HETATM 4475 O  O   . HOH G 5 .   ? 31.660 -58.379 -4.283  1    36.37  ? 750  HOH A O   1 
HETATM 4476 O  O   . HOH G 5 .   ? 21.872 -15.882 -19.852 1    25.78  ? 751  HOH A O   1 
HETATM 4477 O  O   . HOH G 5 .   ? 11.203 -62.74  11.566  1    39.29  ? 752  HOH A O   1 
HETATM 4478 O  O   . HOH G 5 .   ? 27.338 -19.588 -34.978 1    65.7   ? 753  HOH A O   1 
HETATM 4479 O  O   . HOH G 5 .   ? -2.851 -19.28  -36.641 1    37.69  ? 754  HOH A O   1 
HETATM 4480 O  O   . HOH G 5 .   ? 23.487 0.806   -21.92  1    38.24  ? 755  HOH A O   1 
HETATM 4481 O  O   . HOH G 5 .   ? 23.227 -56.734 9.277   1    33.89  ? 756  HOH A O   1 
HETATM 4482 O  O   . HOH G 5 .   ? 15.392 -54.869 17.782  1    37.8   ? 757  HOH A O   1 
HETATM 4483 O  O   . HOH G 5 .   ? 10.305 -55.897 4.194   1    37.11  ? 758  HOH A O   1 
HETATM 4484 O  O   . HOH G 5 .   ? 39.835 -46.196 5.893   1    45.46  ? 759  HOH A O   1 
HETATM 4485 O  O   . HOH G 5 .   ? 11.266 -28.080 -36.162 1    36.81  ? 760  HOH A O   1 
HETATM 4486 O  O   . HOH G 5 .   ? 43.79  -51.108 12.79   1    48.61  ? 761  HOH A O   1 
HETATM 4487 O  O   . HOH G 5 .   ? 33.346 -18.008 -17.336 1    28.78  ? 762  HOH A O   1 
HETATM 4488 O  O   . HOH G 5 .   ? 12.6   -15.063 -0.849  1    42.89  ? 763  HOH A O   1 
HETATM 4489 O  O   . HOH G 5 .   ? 33.715 -7.234  -1.479  1    41.72  ? 764  HOH A O   1 
HETATM 4490 O  O   . HOH G 5 .   ? 22.075 -57.133 12.402  1    40.62  ? 765  HOH A O   1 
HETATM 4491 O  O   . HOH G 5 .   ? 25.823 -53.177 11.692  1    40.39  ? 766  HOH A O   1 
HETATM 4492 O  O   . HOH G 5 .   ? 0.529  -27.483 -22.882 1    33.22  ? 767  HOH A O   1 
HETATM 4493 O  O   . HOH G 5 .   ? 10.597 -31.644 -2.357  1    31.61  ? 768  HOH A O   1 
HETATM 4494 O  O   . HOH G 5 .   ? 35.348 -36.133 -4.519  1    58.24  ? 769  HOH A O   1 
HETATM 4495 O  O   . HOH G 5 .   ? 7.927  -62.569 -7.224  1    44.31  ? 770  HOH A O   1 
HETATM 4496 O  O   . HOH G 5 .   ? 11.303 -31.717 10.703  1    50.93  ? 771  HOH A O   1 
HETATM 4497 O  O   . HOH G 5 .   ? 36.281 -58.023 17.475  1    47.21  ? 772  HOH A O   1 
HETATM 4498 O  O   . HOH G 5 .   ? -7.155 -23.111 -21.806 1    52.76  ? 773  HOH A O   1 
HETATM 4499 O  O   . HOH G 5 .   ? 33.109 -63.625 -0.445  1    37.48  ? 774  HOH A O   1 
HETATM 4500 O  O   . HOH G 5 .   ? 9.084  -40.243 -9.497  1    32.15  ? 775  HOH A O   1 
HETATM 4501 O  O   . HOH G 5 .   ? 18.446 -15.406 -13.499 1    25.66  ? 776  HOH A O   1 
HETATM 4502 O  O   . HOH G 5 .   ? 11.092 -17.737 2.884   1    50.72  ? 777  HOH A O   1 
HETATM 4503 O  O   . HOH G 5 .   ? 15.052 -41.933 -29.735 1    40.95  ? 778  HOH A O   1 
HETATM 4504 O  O   . HOH G 5 .   ? 28.82  1.163   -14.477 1    44.46  ? 779  HOH A O   1 
HETATM 4505 O  O   . HOH G 5 .   ? 21.353 -55.322 7.286   1    40.62  ? 780  HOH A O   1 
HETATM 4506 O  O   . HOH G 5 .   ? 10.536 -72.776 16.575  1    43.07  ? 781  HOH A O   1 
HETATM 4507 O  O   . HOH G 5 .   ? 17.449 -42.118 -12.479 1    28.68  ? 782  HOH A O   1 
HETATM 4508 O  O   . HOH G 5 .   ? 10.889 -44.025 11.243  1    31.3   ? 783  HOH A O   1 
HETATM 4509 O  O   . HOH G 5 .   ? 11.766 -40.561 14.976  1    46.76  ? 784  HOH A O   1 
HETATM 4510 O  O   . HOH G 5 .   ? 8.342  -13.878 -26.1   1    34.53  ? 785  HOH A O   1 
HETATM 4511 O  O   . HOH G 5 .   ? 15.051 -55.603 -5.508  1    39.29  ? 786  HOH A O   1 
HETATM 4512 O  O   . HOH G 5 .   ? 27.244 -27.886 -36.426 1    43.54  ? 787  HOH A O   1 
HETATM 4513 O  O   . HOH G 5 .   ? 26.843 -62.423 19.861  1    44.18  ? 788  HOH A O   1 
HETATM 4514 O  O   . HOH G 5 .   ? 2.411  -36.738 -10.714 1    32.61  ? 789  HOH A O   1 
HETATM 4515 O  O   . HOH G 5 .   ? -5.209 -17.206 -19.184 1    54.03  ? 790  HOH A O   1 
HETATM 4516 O  O   . HOH G 5 .   ? -1.091 -26.435 -24.81  1    34.7   ? 791  HOH A O   1 
HETATM 4517 O  O   . HOH G 5 .   ? 30.896 0.371   -15.945 1    38.66  ? 792  HOH A O   1 
HETATM 4518 O  O   . HOH G 5 .   ? 18.688 -44.694 -6.387  1    53.81  ? 793  HOH A O   1 
HETATM 4519 O  O   . HOH G 5 .   ? 9.829  -11.417 -38.898 1    36.28  ? 794  HOH A O   1 
HETATM 4520 O  O   . HOH G 5 .   ? 18.753 -71.569 5.524   1    47.9   ? 795  HOH A O   1 
HETATM 4521 O  O   . HOH G 5 .   ? 6.007  -34.129 -6.208  1    33.19  ? 796  HOH A O   1 
HETATM 4522 O  O   . HOH G 5 .   ? 26.885 -37.118 -12.137 1    23.55  ? 797  HOH A O   1 
HETATM 4523 O  O   . HOH G 5 .   ? 2.435  -61.73  17.508  1    65.62  ? 798  HOH A O   1 
HETATM 4524 O  O   . HOH G 5 .   ? 23.163 -35.865 26.714  1    65.36  ? 799  HOH A O   1 
HETATM 4525 O  O   . HOH G 5 .   ? 24.764 -65.08  -10.356 1    28.38  ? 800  HOH A O   1 
HETATM 4526 O  O   . HOH G 5 .   ? 20.601 -35.026 1.78    1    42.71  ? 801  HOH A O   1 
HETATM 4527 O  O   . HOH G 5 .   ? 36.525 -27.498 -32.4   1    54.24  ? 802  HOH A O   1 
HETATM 4528 O  O   . HOH G 5 .   ? 11.935 -57.436 -5.014  1    39.84  ? 803  HOH A O   1 
HETATM 4529 O  O   . HOH G 5 .   ? 29.255 -22.768 -14.519 1    24.33  ? 804  HOH A O   1 
HETATM 4530 O  O   . HOH G 5 .   ? 12.495 -10.36  -4.591  1    50.41  ? 805  HOH A O   1 
HETATM 4531 O  O   . HOH G 5 .   ? 37.521 -38.537 20.279  1    66.65  ? 806  HOH A O   1 
HETATM 4532 O  O   . HOH G 5 .   ? 0.722  -13.619 -20.084 1    29.52  ? 807  HOH A O   1 
HETATM 4533 O  O   . HOH G 5 .   ? 19.135 -9.854  -7.704  1    49.87  ? 808  HOH A O   1 
HETATM 4534 O  O   . HOH G 5 .   ? 6.585  -21.281 -0.415  1    42.54  ? 809  HOH A O   1 
HETATM 4535 O  O   . HOH G 5 .   ? 19.7   -34.159 8.594   1    39.46  ? 810  HOH A O   1 
HETATM 4536 O  O   . HOH G 5 .   ? 14.795 -39.164 -2.058  1    44.91  ? 811  HOH A O   1 
HETATM 4537 O  O   . HOH G 5 .   ? 16.701 -21.833 -34.592 1    41.97  ? 812  HOH A O   1 
HETATM 4538 O  O   . HOH G 5 .   ? 35.291 -65.651 3.758   1    55.55  ? 813  HOH A O   1 
HETATM 4539 O  O   . HOH G 5 .   ? 16.963 -22.31  0.396   1    41.97  ? 814  HOH A O   1 
HETATM 4540 O  O   . HOH G 5 .   ? 6.901  -15.294 -11.583 1    29.85  ? 815  HOH A O   1 
HETATM 4541 O  O   . HOH G 5 .   ? 18.013 -11.757 -15.31  1    61.52  ? 816  HOH A O   1 
HETATM 4542 O  O   . HOH G 5 .   ? 12.524 -70.706 17.2    1    52.58  ? 817  HOH A O   1 
HETATM 4543 O  O   . HOH G 5 .   ? 13.946 -55.399 13.552  1    44.02  ? 818  HOH A O   1 
HETATM 4544 O  O   . HOH G 5 .   ? 22.677 -0.465  -5.944  1    49.64  ? 819  HOH A O   1 
HETATM 4545 O  O   . HOH G 5 .   ? 37.47  -41.956 23.59   1    84.18  ? 820  HOH A O   1 
HETATM 4546 O  O   . HOH G 5 .   ? 6.334  -50.602 2.286   1    49.27  ? 821  HOH A O   1 
HETATM 4547 O  O   . HOH G 5 .   ? 32.988 -16.751 -32.924 1    45.85  ? 822  HOH A O   1 
HETATM 4548 O  O   . HOH G 5 .   ? 24.565 -18.469 4.372   1    44.66  ? 823  HOH A O   1 
HETATM 4549 O  O   . HOH G 5 .   ? 33.724 -13.957 -24.255 1    42.27  ? 824  HOH A O   1 
HETATM 4550 O  O   . HOH G 5 .   ? -6.035 -21.205 -26.804 1    59.69  ? 825  HOH A O   1 
HETATM 4551 O  O   . HOH G 5 .   ? 0.434  -32.847 -12.69  1    43.24  ? 826  HOH A O   1 
HETATM 4552 O  O   . HOH G 5 .   ? 41.18  -48.892 16.565  1    47.53  ? 827  HOH A O   1 
HETATM 4553 O  O   . HOH G 5 .   ? 6.175  -17.996 -40.31  1    38.64  ? 828  HOH A O   1 
HETATM 4554 O  O   . HOH G 5 .   ? 13.612 -30.841 1.566   1    49.21  ? 829  HOH A O   1 
HETATM 4555 O  O   . HOH G 5 .   ? 18.452 -19.479 -9.365  1    32.75  ? 830  HOH A O   1 
HETATM 4556 O  O   . HOH G 5 .   ? 19.111 -25.717 -7.054  1    23.72  ? 831  HOH A O   1 
HETATM 4557 O  O   . HOH G 5 .   ? 32.713 -19.719 -20.345 1    26.14  ? 832  HOH A O   1 
HETATM 4558 O  O   . HOH G 5 .   ? 13.207 -9.281  -28.219 1    28.01  ? 833  HOH A O   1 
HETATM 4559 O  O   . HOH G 5 .   ? 5.429  -66.737 14.331  1    38.2   ? 834  HOH A O   1 
HETATM 4560 O  O   . HOH G 5 .   ? 15.234 -15.31  -4.515  1    26.56  ? 835  HOH A O   1 
HETATM 4561 O  O   . HOH G 5 .   ? 30.766 -70.249 5.714   1    53.23  ? 836  HOH A O   1 
HETATM 4562 O  O   . HOH G 5 .   ? 3.379  -18.055 -37.508 1    28.56  ? 837  HOH A O   1 
HETATM 4563 O  O   . HOH G 5 .   ? 17.682 -14.416 -35.581 1    28.22  ? 838  HOH A O   1 
HETATM 4564 O  O   . HOH G 5 .   ? 29.789 -11.941 3.166   1    52.73  ? 839  HOH A O   1 
HETATM 4565 O  O   . HOH G 5 .   ? 28.545 -25.054 1.195   1    48.13  ? 840  HOH A O   1 
HETATM 4566 O  O   . HOH G 5 .   ? 33.863 -11.003 -20.295 1    31.6   ? 841  HOH A O   1 
HETATM 4567 O  O   . HOH G 5 .   ? 0.991  -14.449 -22.65  1    29.03  ? 842  HOH A O   1 
HETATM 4568 O  O   . HOH G 5 .   ? 18.45  -10.059 -26.464 1    24.47  ? 843  HOH A O   1 
HETATM 4569 O  O   . HOH G 5 .   ? 35.384 -23.93  -10.308 1    49.47  ? 844  HOH A O   1 
HETATM 4570 O  O   . HOH G 5 .   ? 24.967 1.234   -19.897 1    42.14  ? 845  HOH A O   1 
HETATM 4571 O  O   . HOH G 5 .   ? 19.168 -13.661 -26.896 1    24.33  ? 846  HOH A O   1 
HETATM 4572 O  O   . HOH G 5 .   ? 1.189  -22.372 -4.053  1    54.9   ? 847  HOH A O   1 
HETATM 4573 O  O   . HOH G 5 .   ? 33.411 -32.965 -27.089 1    37.59  ? 848  HOH A O   1 
HETATM 4574 O  O   . HOH G 5 .   ? 31.945 -35.821 8.556   1    54.15  ? 849  HOH A O   1 
HETATM 4575 O  O   . HOH G 5 .   ? 26.511 -67.057 11.269  1    59.69  ? 850  HOH A O   1 
HETATM 4576 O  O   . HOH G 5 .   ? 32.522 -60.776 -2.817  1    35.03  ? 851  HOH A O   1 
HETATM 4577 O  O   . HOH G 5 .   ? 9.302  -39.697 -21.758 1    50.19  ? 852  HOH A O   1 
HETATM 4578 O  O   . HOH G 5 .   ? 33.644 -12.571 -35.938 1    63.31  ? 853  HOH A O   1 
HETATM 4579 O  O   . HOH G 5 .   ? 23.487 -21.9   -34.488 1    39.05  ? 854  HOH A O   1 
HETATM 4580 O  O   . HOH G 5 .   ? 16.821 -57.297 10.707  1    41.56  ? 855  HOH A O   1 
HETATM 4581 O  O   . HOH G 5 .   ? 13.761 -72.476 -5.805  1    62.81  ? 856  HOH A O   1 
HETATM 4582 O  O   . HOH G 5 .   ? 25.639 -34.678 6.005   1    33.89  ? 857  HOH A O   1 
HETATM 4583 O  O   . HOH G 5 .   ? 25.679 -40.278 7.182   1    31.76  ? 858  HOH A O   1 
HETATM 4584 O  O   . HOH G 5 .   ? 21.758 -29.989 1.155   1    32.68  ? 859  HOH A O   1 
HETATM 4585 O  O   . HOH G 5 .   ? 20.629 -1.847  -27.894 1    46.91  ? 860  HOH A O   1 
HETATM 4586 O  O   . HOH G 5 .   ? 24.285 -13.256 -1.223  1    34.82  ? 861  HOH A O   1 
HETATM 4587 O  O   . HOH G 5 .   ? 25.742 -51     13.133  1    35.92  ? 862  HOH A O   1 
HETATM 4588 O  O   . HOH G 5 .   ? 32.249 -14.114 -21.911 1    30.59  ? 863  HOH A O   1 
HETATM 4589 O  O   . HOH G 5 .   ? 11.512 -43.841 2.44    1    36.42  ? 864  HOH A O   1 
HETATM 4590 O  O   . HOH G 5 .   ? 13.454 -44.099 -15.074 1    35.58  ? 865  HOH A O   1 
HETATM 4591 O  O   . HOH G 5 .   ? 20.121 -7.407  -3.954  1    55.09  ? 866  HOH A O   1 
HETATM 4592 O  O   . HOH G 5 .   ? 13.379 -37.321 -5.686  1    25.15  ? 867  HOH A O   1 
HETATM 4593 O  O   . HOH G 5 .   ? 27.268 -37.962 -32.359 1    29.6   ? 868  HOH A O   1 
HETATM 4594 O  O   . HOH G 5 .   ? 15.829 -45.732 -15.639 1    39.4   ? 869  HOH A O   1 
HETATM 4595 O  O   . HOH G 5 .   ? 16.168 -65.889 -8.105  1    40.94  ? 870  HOH A O   1 
HETATM 4596 O  O   . HOH G 5 .   ? 35.036 -42.076 2.401   1    55.99  ? 871  HOH A O   1 
HETATM 4597 O  O   . HOH G 5 .   ? 14.994 -53.262 0.151   1    35.63  ? 872  HOH A O   1 
HETATM 4598 O  O   . HOH G 5 .   ? 25.435 -43.772 -4.873  1    32.98  ? 873  HOH A O   1 
HETATM 4599 O  O   . HOH G 5 .   ? 5.971  -10.158 -7.851  1    32.88  ? 874  HOH A O   1 
HETATM 4600 O  O   . HOH G 5 .   ? -7.167 -27.830 -22.332 1    55.87  ? 875  HOH A O   1 
HETATM 4601 O  O   . HOH G 5 .   ? 15.847 -46.435 25.754  1    37.24  ? 876  HOH A O   1 
HETATM 4602 O  O   . HOH G 5 .   ? 23.492 -40.230 -16.040 1    22.14  ? 877  HOH A O   1 
HETATM 4603 O  O   . HOH G 5 .   ? 6.604  -73.391 17.511  1    33.91  ? 878  HOH A O   1 
HETATM 4604 O  O   . HOH G 5 .   ? 30.487 -25.38  -3.721  1    47.12  ? 879  HOH A O   1 
HETATM 4605 O  O   . HOH G 5 .   ? 12.485 0.293   -18.619 1    60.61  ? 880  HOH A O   1 
HETATM 4606 O  O   . HOH G 5 .   ? 31.026 -16.644 -18.078 1    25.5   ? 881  HOH A O   1 
HETATM 4607 O  O   . HOH G 5 .   ? 21.218 -30.641 15.032  1    49.74  ? 882  HOH A O   1 
HETATM 4608 O  O   . HOH G 5 .   ? 7.181  -5.154  -9.82   1    42.94  ? 883  HOH A O   1 
HETATM 4609 O  O   . HOH G 5 .   ? 14.291 -48.897 -5.06   1    43.21  ? 884  HOH A O   1 
HETATM 4610 O  O   . HOH G 5 .   ? 17.209 -40.967 -28.783 1    34.12  ? 885  HOH A O   1 
HETATM 4611 O  O   . HOH G 5 .   ? 15.559 -37.584 12.282  1    35.07  ? 886  HOH A O   1 
HETATM 4612 O  O   . HOH G 5 .   ? 1.725  -10.094 -19.718 1    37.82  ? 887  HOH A O   1 
HETATM 4613 O  O   . HOH G 5 .   ? 34.441 -3.967  -19.877 1    34.95  ? 888  HOH A O   1 
HETATM 4614 O  O   . HOH G 5 .   ? 0.494  -19.129 -11.203 1    54.36  ? 889  HOH A O   1 
HETATM 4615 O  O   . HOH G 5 .   ? 24.654 -36.311 1.665   1    32.34  ? 890  HOH A O   1 
HETATM 4616 O  O   . HOH G 5 .   ? 3.3    -29.789 -10.444 1    30.93  ? 891  HOH A O   1 
HETATM 4617 O  O   . HOH G 5 .   ? 18.014 -73.228 13.26   1    51.53  ? 892  HOH A O   1 
HETATM 4618 O  O   . HOH G 5 .   ? 29.187 -38.938 -1.052  1    64.23  ? 893  HOH A O   1 
HETATM 4619 O  O   . HOH G 5 .   ? 8.770  -30.985 -36.817 1    33.41  ? 894  HOH A O   1 
HETATM 4620 O  O   . HOH G 5 .   ? 13.744 -32.633 -2.796  1    40.35  ? 895  HOH A O   1 
HETATM 4621 O  O   . HOH G 5 .   ? 30.019 -40.514 0.55    1    52.4   ? 896  HOH A O   1 
HETATM 4622 O  O   . HOH G 5 .   ? 20.895 -18.387 -19.894 1    26.41  ? 897  HOH A O   1 
HETATM 4623 O  O   . HOH G 5 .   ? 31.765 -6.302  -9.102  1    29.31  ? 898  HOH A O   1 
HETATM 4624 O  O   . HOH G 5 .   ? 13.879 -10.271 -10.276 1    42.82  ? 899  HOH A O   1 
HETATM 4625 O  O   . HOH G 5 .   ? 36.282 -4.578  -13.92  1    40.82  ? 900  HOH A O   1 
HETATM 4626 O  O   . HOH G 5 .   ? 9.561  -66.316 14.227  1    44.58  ? 901  HOH A O   1 
HETATM 4627 O  O   . HOH G 5 .   ? 1.702  -30.388 -18.852 1    35.76  ? 902  HOH A O   1 
HETATM 4628 O  O   . HOH G 5 .   ? 10.712 -47.574 13.638  1    38.11  ? 903  HOH A O   1 
HETATM 4629 O  O   . HOH G 5 .   ? 29.648 -7.8    -26.792 1    34.6   ? 904  HOH A O   1 
HETATM 4630 O  O   . HOH G 5 .   ? 33.821 -23.386 -3.604  1    40.7   ? 905  HOH A O   1 
HETATM 4631 O  O   . HOH G 5 .   ? 10.974 -39.115 -25.980 1    38.63  ? 906  HOH A O   1 
HETATM 4632 O  O   . HOH G 5 .   ? 1.363  -80.686 13.76   1    59.65  ? 907  HOH A O   1 
HETATM 4633 O  O   . HOH G 5 .   ? 32.732 -36.77  5.972   1    57.36  ? 908  HOH A O   1 
HETATM 4634 O  O   . HOH G 5 .   ? 23.57  -70.163 8.452   1    32.81  ? 909  HOH A O   1 
HETATM 4635 O  O   . HOH G 5 .   ? 20.444 -27.109 -35.422 1    32.64  ? 910  HOH A O   1 
HETATM 4636 O  O   . HOH G 5 .   ? 6.044  -55.666 -1.732  1    43.29  ? 911  HOH A O   1 
HETATM 4637 O  O   . HOH G 5 .   ? 18.722 -39.141 -0.843  1    43.72  ? 912  HOH A O   1 
HETATM 4638 O  O   . HOH G 5 .   ? 34.406 -19.604 -29.065 1    45.45  ? 913  HOH A O   1 
HETATM 4639 O  O   . HOH G 5 .   ? 33.178 -53.628 -2.713  1    61.95  ? 914  HOH A O   1 
HETATM 4640 O  O   . HOH G 5 .   ? 1.939  -36.069 -21.76  1    49.38  ? 915  HOH A O   1 
HETATM 4641 O  O   . HOH G 5 .   ? 37.844 -13.622 -18.736 1    59.68  ? 916  HOH A O   1 
HETATM 4642 O  O   . HOH G 5 .   ? 21.178 -29.682 -36.113 1    49.59  ? 917  HOH A O   1 
HETATM 4643 O  O   . HOH G 5 .   ? 19.977 -21.472 -7.827  1    40.13  ? 918  HOH A O   1 
HETATM 4644 O  O   . HOH G 5 .   ? 5.772  -14.946 -14.311 1    31.98  ? 919  HOH A O   1 
HETATM 4645 O  O   . HOH G 5 .   ? 20.355 -42.386 -30.959 1    43.17  ? 920  HOH A O   1 
HETATM 4646 O  O   . HOH G 5 .   ? 28.778 -20.112 -14.762 1    26.75  ? 921  HOH A O   1 
HETATM 4647 O  O   . HOH G 5 .   ? 16.216 -12.379 -36.694 1    31.89  ? 922  HOH A O   1 
HETATM 4648 O  O   . HOH G 5 .   ? 35.213 -66.718 12.005  1    51.78  ? 923  HOH A O   1 
HETATM 4649 O  O   . HOH G 5 .   ? 4.896  -26.69  -29.147 1    31.93  ? 924  HOH A O   1 
HETATM 4650 O  O   . HOH G 5 .   ? 13.827 -2.656  -37.995 1    68.17  ? 925  HOH A O   1 
HETATM 4651 O  O   . HOH G 5 .   ? 32.205 -4.018  -7.541  1    31.54  ? 926  HOH A O   1 
HETATM 4652 O  O   . HOH G 5 .   ? 31.012 -6.574  -25.084 1    36.53  ? 927  HOH A O   1 
HETATM 4653 O  O   . HOH G 5 .   ? 35.469 -11.795 -24.582 1    40.96  ? 928  HOH A O   1 
HETATM 4654 O  O   . HOH G 5 .   ? 20.561 -27.58  18.484  1    63.06  ? 929  HOH A O   1 
HETATM 4655 O  O   . HOH G 5 .   ? -6.631 -18.172 -28.051 1    50.45  ? 930  HOH A O   1 
HETATM 4656 O  O   . HOH G 5 .   ? 1.184  -10.531 -30.888 1    38.65  ? 931  HOH A O   1 
HETATM 4657 O  O   . HOH G 5 .   ? 22.536 -46.900 24.291  1    45.37  ? 932  HOH A O   1 
HETATM 4658 O  O   . HOH G 5 .   ? 18.909 -20.387 -13.319 1    25.53  ? 933  HOH A O   1 
HETATM 4659 O  O   . HOH G 5 .   ? 34.243 -58.411 20.058  1    47.13  ? 934  HOH A O   1 
HETATM 4660 O  O   . HOH G 5 .   ? 15.904 -15.848 -39.231 1    45.54  ? 935  HOH A O   1 
HETATM 4661 O  O   . HOH G 5 .   ? 7.137  -10.445 -25.696 1    44.15  ? 936  HOH A O   1 
HETATM 4662 O  O   . HOH G 5 .   ? 1.226  -61.717 9.303   1    43.01  ? 937  HOH A O   1 
HETATM 4663 O  O   . HOH G 5 .   ? 25.434 -52.137 -2.439  1    47.73  ? 938  HOH A O   1 
HETATM 4664 O  O   . HOH G 5 .   ? 18.543 -64.432 -12.292 1    64.43  ? 939  HOH A O   1 
HETATM 4665 O  O   . HOH G 5 .   ? 19.346 -5.513  -28.035 1    31.32  ? 940  HOH A O   1 
HETATM 4666 O  O   . HOH G 5 .   ? 6.397  -14.503 -30.145 1    27.38  ? 941  HOH A O   1 
HETATM 4667 O  O   . HOH G 5 .   ? 37.22  -3.566  -5.894  1    61.31  ? 942  HOH A O   1 
HETATM 4668 O  O   . HOH G 5 .   ? -7.174 -21.045 -24.679 1    47.65  ? 943  HOH A O   1 
HETATM 4669 O  O   . HOH G 5 .   ? 35.065 -29.944 -14.481 1    44.07  ? 944  HOH A O   1 
HETATM 4670 O  O   . HOH G 5 .   ? 3.999  -78.39  15.807  1    40.19  ? 945  HOH A O   1 
HETATM 4671 O  O   . HOH G 5 .   ? 39.65  -58.239 10.726  1    42.52  ? 946  HOH A O   1 
HETATM 4672 O  O   . HOH G 5 .   ? 8.003  -14.3   -23.393 1    34.5   ? 947  HOH A O   1 
HETATM 4673 O  O   . HOH G 5 .   ? 24.956 -26.005 -34.076 1    33.32  ? 948  HOH A O   1 
HETATM 4674 O  O   . HOH G 5 .   ? 30.663 -18.425 -16.022 1    21.39  ? 949  HOH A O   1 
HETATM 4675 O  O   . HOH G 5 .   ? 35.397 -11.092 -32.991 1    58.08  ? 950  HOH A O   1 
HETATM 4676 O  O   . HOH G 5 .   ? 9.817  -50.67  20.615  1    58.67  ? 951  HOH A O   1 
HETATM 4677 O  O   . HOH G 5 .   ? 23.704 -50.448 -5.52   1    31.78  ? 952  HOH A O   1 
HETATM 4678 O  O   . HOH G 5 .   ? 28.506 -36.996 -18.824 1    30.72  ? 953  HOH A O   1 
HETATM 4679 O  O   . HOH G 5 .   ? 29.204 -45.106 1.516   1    42.11  ? 954  HOH A O   1 
HETATM 4680 O  O   . HOH G 5 .   ? 31.686 -26.464 -14.063 1    32.18  ? 955  HOH A O   1 
HETATM 4681 O  O   . HOH G 5 .   ? 23.706 -32.074 0.327   1    32.25  ? 956  HOH A O   1 
HETATM 4682 O  O   . HOH G 5 .   ? 35.871 -32.132 -16.129 1    44.15  ? 957  HOH A O   1 
HETATM 4683 O  O   . HOH G 5 .   ? 15.201 -39.507 -27.164 1    47.95  ? 958  HOH A O   1 
HETATM 4684 O  O   . HOH G 5 .   ? 4.325  -63.437 3.567   1    51.13  ? 959  HOH A O   1 
HETATM 4685 O  O   . HOH G 5 .   ? 29.488 -39.548 24.819  1    46.89  ? 960  HOH A O   1 
HETATM 4686 O  O   . HOH G 5 .   ? 24.592 -35.372 -4.898  1    37.59  ? 961  HOH A O   1 
HETATM 4687 O  O   . HOH G 5 .   ? 12.557 -37.669 8.081   1    53.9   ? 962  HOH A O   1 
HETATM 4688 O  O   . HOH G 5 .   ? 40.211 -52.865 19.594  1    45.53  ? 963  HOH A O   1 
HETATM 4689 O  O   . HOH G 5 .   ? 21.12  -11.468 -37.624 1    66.91  ? 964  HOH A O   1 
HETATM 4690 O  O   . HOH G 5 .   ? 14.056 -35.702 21.881  1    51.5   ? 965  HOH A O   1 
HETATM 4691 O  O   . HOH G 5 .   ? 17.915 -60.146 -15.131 1    35.99  ? 966  HOH A O   1 
HETATM 4692 O  O   . HOH G 5 .   ? 23.395 -32.381 -36.264 1    45.67  ? 967  HOH A O   1 
HETATM 4693 O  O   . HOH G 5 .   ? 4.18   -4.364  -26.994 1    55.18  ? 968  HOH A O   1 
HETATM 4694 O  O   . HOH G 5 .   ? 14.512 -48.453 20.061  1    30.91  ? 969  HOH A O   1 
HETATM 4695 O  O   . HOH G 5 .   ? 19.769 -56.368 1.823   1    48.3   ? 970  HOH A O   1 
HETATM 4696 O  O   . HOH G 5 .   ? 39.886 -50.711 5.542   1    55.19  ? 971  HOH A O   1 
HETATM 4697 O  O   . HOH G 5 .   ? 12.97  -25.162 0.327   1    35.47  ? 972  HOH A O   1 
HETATM 4698 O  O   . HOH G 5 .   ? 15.955 -32.472 19.938  1    73.02  ? 973  HOH A O   1 
HETATM 4699 O  O   . HOH G 5 .   ? 23.294 -22.657 -24.565 1    24.51  ? 974  HOH A O   1 
HETATM 4700 O  O   . HOH G 5 .   ? 24.668 -7.326  -33.303 1    55.11  ? 975  HOH A O   1 
HETATM 4701 O  O   . HOH G 5 .   ? 17.564 -37.506 23.934  1    41.53  ? 976  HOH A O   1 
HETATM 4702 O  O   . HOH G 5 .   ? 1.774  -9.435  -27.583 1    53.4   ? 977  HOH A O   1 
HETATM 4703 O  O   . HOH G 5 .   ? 31.158 -9.586  1.294   1    39.43  ? 978  HOH A O   1 
HETATM 4704 O  O   . HOH G 5 .   ? 40.366 -17.585 -19.225 1    57.46  ? 979  HOH A O   1 
HETATM 4705 O  O   . HOH G 5 .   ? 1.859  -22.557 -0.955  1    62.12  ? 980  HOH A O   1 
HETATM 4706 O  O   . HOH G 5 .   ? 36.325 -14.059 -32.441 1    62.02  ? 981  HOH A O   1 
HETATM 4707 O  O   . HOH G 5 .   ? 37.428 -15.327 -30.258 1    66.84  ? 982  HOH A O   1 
HETATM 4708 O  O   . HOH G 5 .   ? 10.429 -54.123 24.031  1    50.38  ? 983  HOH A O   1 
HETATM 4709 O  O   . HOH G 5 .   ? 1.845  -20.279 -12.97  1    39.49  ? 984  HOH A O   1 
HETATM 4710 O  O   . HOH G 5 .   ? 19.778 -61.281 19.171  1    41.38  ? 985  HOH A O   1 
HETATM 4711 O  O   . HOH G 5 .   ? 0.758  -38.121 -19.885 1    57.63  ? 986  HOH A O   1 
HETATM 4712 O  O   . HOH G 5 .   ? 30.621 -2.992  3.065   1    45.03  ? 987  HOH A O   1 
HETATM 4713 O  O   . HOH G 5 .   ? 31.492 -15.74  4.659   1    49.9   ? 988  HOH A O   1 
HETATM 4714 O  O   . HOH G 5 .   ? 15.073 -56.253 20.045  1    42.95  ? 989  HOH A O   1 
HETATM 4715 O  O   . HOH G 5 .   ? 6.595  -61.071 1.609   1    41.99  ? 990  HOH A O   1 
HETATM 4716 O  O   . HOH G 5 .   ? -1.249 -7.034  -34.907 1    59.94  ? 991  HOH A O   1 
HETATM 4717 O  O   . HOH G 5 .   ? 35.532 -12.299 -14.71  1    36.58  ? 992  HOH A O   1 
HETATM 4718 O  O   . HOH G 5 .   ? 17.31  -40.62  -22.054 1    43.65  ? 993  HOH A O   1 
HETATM 4719 O  O   . HOH G 5 .   ? 9.707  -56.147 11.124  1    50.79  ? 994  HOH A O   1 
HETATM 4720 O  O   . HOH G 5 .   ? 19.394 -22.485 0.128   1    49.96  ? 995  HOH A O   1 
HETATM 4721 O  O   . HOH G 5 .   ? 29.057 -19.733 4.62    1    35.29  ? 996  HOH A O   1 
HETATM 4722 O  O   . HOH G 5 .   ? 7.223  -7.511  -28.476 1    42.32  ? 997  HOH A O   1 
HETATM 4723 O  O   . HOH G 5 .   ? 30.029 -0.691  2.138   1    46.39  ? 998  HOH A O   1 
HETATM 4724 O  O   . HOH G 5 .   ? 35.534 -31.698 -30.671 1    43.8   ? 999  HOH A O   1 
HETATM 4725 O  O   . HOH G 5 .   ? 14.377 -11.644 -5.854  1    41.45  ? 1000 HOH A O   1 
HETATM 4726 O  O   . HOH G 5 .   ? 10.034 -43.629 -17.417 1    59.96  ? 1001 HOH A O   1 
HETATM 4727 O  O   . HOH G 5 .   ? 31.44  -50.373 -0.396  1    34.69  ? 1002 HOH A O   1 
HETATM 4728 O  O   . HOH G 5 .   ? 31.396 -19.008 -32.613 1    46.23  ? 1003 HOH A O   1 
HETATM 4729 O  O   . HOH G 5 .   ? 2.21   -17.617 -30.353 1    37.46  ? 1004 HOH A O   1 
HETATM 4730 O  O   . HOH G 5 .   ? -1.416 -18.103 -32.337 1    42.15  ? 1005 HOH A O   1 
HETATM 4731 O  O   . HOH G 5 .   ? 15.563 -44.016 -9.048  1    55.59  ? 1006 HOH A O   1 
HETATM 4732 O  O   . HOH G 5 .   ? 19.577 -57.011 10.726  1    37.58  ? 1007 HOH A O   1 
HETATM 4733 O  O   . HOH G 5 .   ? 36.686 -63.725 13.892  1    64.03  ? 1008 HOH A O   1 
HETATM 4734 O  O   . HOH G 5 .   ? 4.012  -55.853 -0.125  1    65.31  ? 1009 HOH A O   1 
HETATM 4735 O  O   . HOH G 5 .   ? 0.552  -15.441 -30.901 1    38.05  ? 1010 HOH A O   1 
HETATM 4736 O  O   . HOH G 5 .   ? 17.132 -14.782 -32.715 1    26.94  ? 1011 HOH A O   1 
HETATM 4737 O  O   . HOH G 5 .   ? 36.918 -10.287 -8.804  1    42.96  ? 1012 HOH A O   1 
HETATM 4738 O  O   . HOH G 5 .   ? 27.742 -12.304 6.127   1    53.57  ? 1013 HOH A O   1 
HETATM 4739 O  O   . HOH G 5 .   ? 13.325 2.546   -13.904 1    58.66  ? 1014 HOH A O   1 
HETATM 4740 O  O   . HOH G 5 .   ? 25.004 -75.039 1.985   1    58.93  ? 1015 HOH A O   1 
HETATM 4741 O  O   . HOH G 5 .   ? 4.588  -68.145 -1.338  1    58.81  ? 1016 HOH A O   1 
HETATM 4742 O  O   . HOH G 5 .   ? 10.607 -43.019 6.499   1    33.07  ? 1017 HOH A O   1 
HETATM 4743 O  O   . HOH G 5 .   ? 10.507 -53.831 10.768  1    45.99  ? 1018 HOH A O   1 
HETATM 4744 O  O   . HOH G 5 .   ? 12.67  -36.836 -22.594 1    46.46  ? 1019 HOH A O   1 
HETATM 4745 O  O   . HOH G 5 .   ? 26.147 -50.159 -3.969  1    41.1   ? 1020 HOH A O   1 
HETATM 4746 O  O   . HOH G 5 .   ? 17.598 -59.312 18.912  1    56.77  ? 1021 HOH A O   1 
HETATM 4747 O  O   . HOH G 5 .   ? 35.161 -32.353 -3.034  1    58.63  ? 1022 HOH A O   1 
HETATM 4748 O  O   . HOH G 5 .   ? 22.858 -51.209 23.863  1    50.56  ? 1023 HOH A O   1 
HETATM 4749 O  O   . HOH G 5 .   ? 6.832  -36.946 -27.613 1    40.44  ? 1024 HOH A O   1 
HETATM 4750 O  O   . HOH G 5 .   ? 4.651  -16.5   -30.859 1    30.04  ? 1025 HOH A O   1 
HETATM 4751 O  O   . HOH G 5 .   ? 15.035 -64.274 -9.959  1    39.58  ? 1026 HOH A O   1 
HETATM 4752 O  O   . HOH G 5 .   ? 18.876 -43.337 -19.25  1    30.12  ? 1027 HOH A O   1 
HETATM 4753 O  O   . HOH G 5 .   ? 22.783 -30.086 17.88   1    57.22  ? 1028 HOH A O   1 
HETATM 4754 O  O   . HOH G 5 .   ? 12.992 -21.02  2.327   1    48.87  ? 1029 HOH A O   1 
HETATM 4755 O  O   . HOH G 5 .   ? 9.876  -84.894 15.292  1    59.28  ? 1030 HOH A O   1 
HETATM 4756 O  O   . HOH G 5 .   ? 19.327 -0.498  -5.327  1    76.6   ? 1031 HOH A O   1 
HETATM 4757 O  O   . HOH G 5 .   ? -2.422 -12.516 -25.202 1    58.72  ? 1032 HOH A O   1 
HETATM 4758 O  O   . HOH G 5 .   ? 19.475 -56.844 4.396   1    52.16  ? 1033 HOH A O   1 
HETATM 4759 O  O   . HOH G 5 .   ? 7.957  -45.093 18.973  1    49.84  ? 1034 HOH A O   1 
HETATM 4760 O  O   . HOH G 5 .   ? 14.73  -20.556 -37.7   1    44.84  ? 1035 HOH A O   1 
HETATM 4761 O  O   . HOH G 5 .   ? 17.459 -10.937 -5.562  1    44.3   ? 1036 HOH A O   1 
HETATM 4762 O  O   . HOH G 5 .   ? 10.811 -27.268 9.968   1    49.84  ? 1037 HOH A O   1 
HETATM 4763 O  O   . HOH G 5 .   ? 24.167 -25.138 1.259   1    60.88  ? 1038 HOH A O   1 
HETATM 4764 O  O   . HOH G 5 .   ? -0.364 -31.737 -24.689 1    41.79  ? 1039 HOH A O   1 
HETATM 4765 O  O   . HOH G 5 .   ? 35.098 -25.821 -13.684 1    42.14  ? 1040 HOH A O   1 
HETATM 4766 O  O   . HOH G 5 .   ? 15.343 -30.997 -35.294 1    30.41  ? 1041 HOH A O   1 
HETATM 4767 O  O   . HOH G 5 .   ? 29.22  -30.123 -36.159 1    63.27  ? 1042 HOH A O   1 
HETATM 4768 O  O   . HOH G 5 .   ? 26.268 -36.133 3.667   1    36.74  ? 1043 HOH A O   1 
HETATM 4769 O  O   . HOH G 5 .   ? 23.098 -22.854 -27.289 1    24.9   ? 1044 HOH A O   1 
HETATM 4770 O  O   . HOH G 5 .   ? 15.441 -19.287 1.281   1    42.81  ? 1045 HOH A O   1 
HETATM 4771 O  O   . HOH G 5 .   ? 27.426 -34.9   -5.266  1    38.07  ? 1046 HOH A O   1 
HETATM 4772 O  O   . HOH G 5 .   ? 35.913 -6.296  -28.333 1    45.08  ? 1047 HOH A O   1 
HETATM 4773 O  O   . HOH G 5 .   ? 27.582 -50.246 24.895  1    54.59  ? 1048 HOH A O   1 
HETATM 4774 O  O   . HOH G 5 .   ? 31.202 -10.438 -36.36  1    63.81  ? 1049 HOH A O   1 
HETATM 4775 O  O   . HOH G 5 .   ? 35.513 -19.608 -24.831 1    35.41  ? 1050 HOH A O   1 
HETATM 4776 O  O   . HOH G 5 .   ? 0.938  -1.936  -30.053 1    58.56  ? 1051 HOH A O   1 
HETATM 4777 O  O   . HOH G 5 .   ? 17.82  -30.285 10.198  1    58.99  ? 1052 HOH A O   1 
HETATM 4778 O  O   . HOH G 5 .   ? 13.244 -25.794 7.668   1    61.35  ? 1053 HOH A O   1 
HETATM 4779 O  O   . HOH G 5 .   ? 32.093 -53.811 1.548   1    34.54  ? 1054 HOH A O   1 
HETATM 4780 O  O   . HOH G 5 .   ? 21.79  -42.943 25.493  1    34.46  ? 1055 HOH A O   1 
HETATM 4781 O  O   . HOH G 5 .   ? 21.806 -74.845 6.021   1    37.74  ? 1056 HOH A O   1 
HETATM 4782 O  O   . HOH G 5 .   ? 36.74  -14.181 -4.467  1    44.64  ? 1057 HOH A O   1 
HETATM 4783 O  O   . HOH G 5 .   ? -4.38  -17.185 -15.981 1    54.36  ? 1058 HOH A O   1 
HETATM 4784 O  O   . HOH G 5 .   ? 10.883 -50.166 13.769  1    46.96  ? 1059 HOH A O   1 
HETATM 4785 O  O   . HOH G 5 .   ? 19.326 -7.303  -32.383 1    30.78  ? 1060 HOH A O   1 
HETATM 4786 O  O   . HOH G 5 .   ? 18.495 -21.66  2.594   1    60.97  ? 1061 HOH A O   1 
HETATM 4787 O  O   . HOH G 5 .   ? 23.775 -16.199 5.747   1    54.05  ? 1062 HOH A O   1 
HETATM 4788 O  O   . HOH G 5 .   ? 24.701 -3.798  -28.064 1    38.65  ? 1063 HOH A O   1 
HETATM 4789 O  O   . HOH G 5 .   ? 19.831 -76.937 2.547   1    45.02  ? 1064 HOH A O   1 
HETATM 4790 O  O   . HOH G 5 .   ? 13.693 -10.417 -24.034 1    45.84  ? 1065 HOH A O   1 
HETATM 4791 O  O   . HOH G 5 .   ? 39.121 -5.813  -10.8   1    55.62  ? 1066 HOH A O   1 
HETATM 4792 O  O   . HOH G 5 .   ? 10.485 -46.752 5.752   1    52.35  ? 1067 HOH A O   1 
HETATM 4793 O  O   . HOH G 5 .   ? 3.273  -68.234 13.637  1    42.11  ? 1068 HOH A O   1 
HETATM 4794 O  O   . HOH G 5 .   ? 35.354 -17.531 -30.408 1    56.19  ? 1069 HOH A O   1 
HETATM 4795 O  O   . HOH G 5 .   ? 9.479  -44.608 15.88   1    36.71  ? 1070 HOH A O   1 
HETATM 4796 O  O   . HOH G 5 .   ? 10.592 -23.28  2.673   1    52.84  ? 1071 HOH A O   1 
HETATM 4797 O  O   . HOH G 5 .   ? 34.785 -21.728 -15.946 1    37.03  ? 1072 HOH A O   1 
HETATM 4798 O  O   . HOH G 5 .   ? 19.255 -11.451 -13.049 1    51.03  ? 1073 HOH A O   1 
HETATM 4799 O  O   . HOH G 5 .   ? -0.893 -38.999 -16.279 1    65.75  ? 1074 HOH A O   1 
HETATM 4800 O  O   . HOH G 5 .   ? -2.596 -26.334 -13.391 1    34.09  ? 1075 HOH A O   1 
HETATM 4801 O  O   . HOH G 5 .   ? 32.975 -47.905 1.442   1    40.44  ? 1076 HOH A O   1 
HETATM 4802 O  O   . HOH G 5 .   ? 20.866 -18.793 -37.413 1    46.52  ? 1077 HOH A O   1 
HETATM 4803 O  O   . HOH G 5 .   ? 12.905 -9.225  -7.55   1    48.61  ? 1078 HOH A O   1 
HETATM 4804 O  O   . HOH G 5 .   ? 19     -9.109  -5.366  1    46.94  ? 1079 HOH A O   1 
HETATM 4805 O  O   . HOH G 5 .   ? -7.826 -18.977 -23.085 1    55.35  ? 1080 HOH A O   1 
HETATM 4806 O  O   . HOH G 5 .   ? 13.449 -46.288 -0.312  1    36.61  ? 1081 HOH A O   1 
HETATM 4807 O  O   . HOH G 5 .   ? 14.659 -10.928 -26.63  1    36.33  ? 1082 HOH A O   1 
HETATM 4808 O  O   . HOH G 5 .   ? 20.46  -38.653 -6.644  1    43.76  ? 1083 HOH A O   1 
HETATM 4809 O  O   . HOH G 5 .   ? 20.488 -12.263 5.769   1    64.54  ? 1084 HOH A O   1 
HETATM 4810 O  O   . HOH G 5 .   ? 3.147  -26.472 -4.732  1    48.15  ? 1085 HOH A O   1 
HETATM 4811 O  O   . HOH G 5 .   ? 17.068 -34.849 -0.448  1    41.31  ? 1086 HOH A O   1 
HETATM 4812 O  O   . HOH G 5 .   ? 19.283 -37.581 -2.797  1    43.83  ? 1087 HOH A O   1 
HETATM 4813 O  O   . HOH G 5 .   ? 29.638 -8.093  -31.567 1    29.58  ? 1088 HOH A O   1 
HETATM 4814 O  O   . HOH G 5 .   ? 38.567 -47.442 23.17   1    48.1   ? 1089 HOH A O   1 
HETATM 4815 O  O   . HOH G 5 .   ? 19.198 -17.919 -40.018 1    57.96  ? 1090 HOH A O   1 
HETATM 4816 O  O   . HOH G 5 .   ? 0.065  -8.791  -18.012 1    52.08  ? 1091 HOH A O   1 
HETATM 4817 O  O   . HOH G 5 .   ? 3.236  -38.97  -18.846 1    58.24  ? 1092 HOH A O   1 
HETATM 4818 O  O   . HOH G 5 .   ? 18.653 -5.078  -30.53  1    36.47  ? 1093 HOH A O   1 
HETATM 4819 O  O   . HOH G 5 .   ? 28.562 -36.647 0.32    1    53.98  ? 1094 HOH A O   1 
HETATM 4820 O  O   . HOH G 5 .   ? 6.531  -61.746 -5.031  1    59.63  ? 1095 HOH A O   1 
HETATM 4821 O  O   . HOH G 5 .   ? 22.392 -61.51  9.554   1    46.64  ? 1096 HOH A O   1 
HETATM 4822 O  O   . HOH G 5 .   ? 12.924 -40.642 -27.183 1    49.92  ? 1097 HOH A O   1 
HETATM 4823 O  O   . HOH G 5 .   ? 2.596  -11.66  -6.761  1    47.59  ? 1098 HOH A O   1 
HETATM 4824 O  O   . HOH G 5 .   ? 36.606 -24.593 -19.482 1    50.95  ? 1099 HOH A O   1 
HETATM 4825 O  O   . HOH G 5 .   ? -0.28  -28.554 -12.158 1    42.25  ? 1100 HOH A O   1 
HETATM 4826 O  O   . HOH G 5 .   ? 13.102 2.513   -17.428 1    71.6   ? 1101 HOH A O   1 
HETATM 4827 O  O   . HOH G 5 .   ? 4.421  -22.158 -1.858  1    42.3   ? 1102 HOH A O   1 
HETATM 4828 O  O   . HOH G 5 .   ? 1.796  -10.562 -9.706  1    39.01  ? 1103 HOH A O   1 
HETATM 4829 O  O   . HOH G 5 .   ? 16.755 -33.942 2.307   1    59.05  ? 1104 HOH A O   1 
HETATM 4830 O  O   . HOH G 5 .   ? 1.382  -14.019 -6.811  1    41.38  ? 1105 HOH A O   1 
HETATM 4831 O  O   . HOH G 5 .   ? -8.4   -14.35  -22.559 1    60.82  ? 1106 HOH A O   1 
HETATM 4832 O  O   . HOH G 5 .   ? 30.532 -37.92  22.775  1    62.02  ? 1107 HOH A O   1 
HETATM 4833 O  O   . HOH G 5 .   ? 29.805 0.498   -6.437  1    47.37  ? 1108 HOH A O   1 
HETATM 4834 O  O   . HOH G 5 .   ? 36.937 -21.836 -28.932 1    50.14  ? 1109 HOH A O   1 
HETATM 4835 O  O   . HOH G 5 .   ? -2.328 -25.613 -10.741 1    47.46  ? 1110 HOH A O   1 
HETATM 4836 O  O   . HOH G 5 .   ? 1.96   -25.154 -7.035  1    42.34  ? 1111 HOH A O   1 
HETATM 4837 O  O   . HOH G 5 .   ? 36.121 -11.993 -5.899  1    37.27  ? 1112 HOH A O   1 
HETATM 4838 O  O   . HOH G 5 .   ? 1.644  -60.213 1.815   1    81.67  ? 1113 HOH A O   1 
HETATM 4839 O  O   . HOH G 5 .   ? 38.316 -43.066 8.448   1    66.99  ? 1114 HOH A O   1 
HETATM 4840 O  O   . HOH G 5 .   ? 15.449 -58.172 15.265  1    54.12  ? 1115 HOH A O   1 
HETATM 4841 O  O   . HOH G 5 .   ? 8.243  -37.944 24.164  1    45.27  ? 1116 HOH A O   1 
HETATM 4842 O  O   . HOH G 5 .   ? 20.072 -28.523 5.572   1    43.99  ? 1117 HOH A O   1 
HETATM 4843 O  O   . HOH G 5 .   ? 26.206 -57.078 -2.402  1    47.93  ? 1118 HOH A O   1 
HETATM 4844 O  O   . HOH G 5 .   ? 21.917 -62.049 12.066  1    54.22  ? 1119 HOH A O   1 
HETATM 4845 O  O   . HOH G 5 .   ? 5.551  -8.377  -26.609 1    58.55  ? 1120 HOH A O   1 
HETATM 4846 O  O   . HOH G 5 .   ? 11.605 -44.383 -0.276  1    56.62  ? 1121 HOH A O   1 
HETATM 4847 O  O   . HOH G 5 .   ? 41.539 -52.728 14.235  1    44.59  ? 1122 HOH A O   1 
HETATM 4848 O  O   . HOH G 5 .   ? 18.073 -32.805 10.286  1    52.7   ? 1123 HOH A O   1 
HETATM 4849 O  O   . HOH G 5 .   ? 32.271 -9.525  -1.185  1    45.35  ? 1124 HOH A O   1 
HETATM 4850 O  O   . HOH G 5 .   ? 18.157 -26.582 -36.719 1    44.18  ? 1125 HOH A O   1 
HETATM 4851 O  O   . HOH G 5 .   ? 22.632 -22.762 1.598   1    61.24  ? 1126 HOH A O   1 
HETATM 4852 O  O   . HOH G 5 .   ? -6.194 -20.435 -15.842 1    71.52  ? 1127 HOH A O   1 
HETATM 4853 O  O   . HOH G 5 .   ? 36.957 -10.911 -12.941 1    49.76  ? 1128 HOH A O   1 
HETATM 4854 O  O   . HOH G 5 .   ? 1.873  -27.588 -9.135  1    54.5   ? 1129 HOH A O   1 
HETATM 4855 O  O   . HOH G 5 .   ? 15.344 -39.958 -23.432 1    39.99  ? 1130 HOH A O   1 
HETATM 4856 O  O   . HOH G 5 .   ? 29.493 -14.336 -35.238 1    66.05  ? 1131 HOH A O   1 
HETATM 4857 O  O   . HOH G 5 .   ? 22.937 -67.871 9.77    1    43.13  ? 1132 HOH A O   1 
HETATM 4858 O  O   . HOH G 5 .   ? 19.44  -65.618 12.037  1    56.83  ? 1133 HOH A O   1 
HETATM 4859 O  O   . HOH G 5 .   ? 29.739 -63.882 18.657  1    61.53  ? 1134 HOH A O   1 
HETATM 4860 O  O   . HOH G 5 .   ? 0.528  -75.802 11.192  1    62.84  ? 1135 HOH A O   1 
HETATM 4861 O  O   . HOH G 5 .   ? 6.176  -52.619 -3.022  1    64.53  ? 1136 HOH A O   1 
HETATM 4862 O  O   . HOH G 5 .   ? 5.716  -64.134 14.524  1    49.74  ? 1137 HOH A O   1 
HETATM 4863 O  O   . HOH G 5 .   ? 4.712  -24.371 -3.739  1    41.76  ? 1138 HOH A O   1 
HETATM 4864 O  O   . HOH G 5 .   ? 27.436 -38.196 -2.751  1    48.62  ? 1139 HOH A O   1 
HETATM 4865 O  O   . HOH G 5 .   ? 13.392 -44.789 -10.438 1    78.01  ? 1140 HOH A O   1 
HETATM 4866 O  O   . HOH G 5 .   ? 33.801 -9.629  -31.277 1    62.08  ? 1141 HOH A O   1 
HETATM 4867 O  O   . HOH G 5 .   ? 14.45  -52.135 -2.558  1    52.12  ? 1142 HOH A O   1 
HETATM 4868 O  O   . HOH G 5 .   ? -1.522 -13.664 -33.723 1    74.39  ? 1143 HOH A O   1 
HETATM 4869 O  O   . HOH G 5 .   ? 14.39  -23.403 1.534   1    39.52  ? 1144 HOH A O   1 
HETATM 4870 O  O   . HOH G 5 .   ? 5.45   -55.637 6.256   1    68.98  ? 1145 HOH A O   1 
HETATM 4871 O  O   . HOH G 5 .   ? 7.612  1.257   -31.886 1    55.39  ? 1146 HOH A O   1 
HETATM 4872 O  O   . HOH G 5 .   ? 25.319 -6.791  -36.639 1    63.74  ? 1147 HOH A O   1 
HETATM 4873 O  O   . HOH G 5 .   ? 31.969 -2.213  -9.477  1    53.82  ? 1148 HOH A O   1 
HETATM 4874 O  O   . HOH G 5 .   ? 31.279 -41.524 25.096  1    60.62  ? 1149 HOH A O   1 
HETATM 4875 O  O   . HOH G 5 .   ? 10.484 -40.453 0.911   1    62.9   ? 1150 HOH A O   1 
HETATM 4876 O  O   . HOH G 5 .   ? 18.776 -38.786 -32.052 1    45.59  ? 1151 HOH A O   1 
HETATM 4877 O  O   . HOH G 5 .   ? 12.572 -33.702 -36.667 1    41.37  ? 1152 HOH A O   1 
HETATM 4878 O  O   . HOH G 5 .   ? 3.318  -33.497 -5.073  1    55.24  ? 1153 HOH A O   1 
HETATM 4879 O  O   . HOH G 5 .   ? 18.713 -33.889 12.36   1    52.15  ? 1154 HOH A O   1 
HETATM 4880 O  O   . HOH G 5 .   ? 5.65   -54.479 9.185   1    63.56  ? 1155 HOH A O   1 
HETATM 4881 O  O   . HOH G 5 .   ? 24.775 -65.23  8.821   1    46.09  ? 1156 HOH A O   1 
HETATM 4882 O  O   . HOH G 5 .   ? 14.892 -46.246 -4.609  1    56.7   ? 1157 HOH A O   1 
HETATM 4883 O  O   . HOH G 5 .   ? -0.839 -23.322 -9.585  1    56.94  ? 1158 HOH A O   1 
HETATM 4884 O  O   . HOH G 5 .   ? 10.278 -33.632 -4.355  1    37.71  ? 1159 HOH A O   1 
HETATM 4885 O  O   . HOH G 5 .   ? 23.184 -27.646 1.03    1    57.12  ? 1160 HOH A O   1 
HETATM 4886 O  O   . HOH G 5 .   ? 36.31  -17.641 0.78    1    63.58  ? 1161 HOH A O   1 
HETATM 4887 O  O   . HOH G 5 .   ? 30.277 -6.081  -29.272 1    47.11  ? 1162 HOH A O   1 
HETATM 4888 O  O   . HOH G 5 .   ? 1.648  -39.134 -12.015 1    42.18  ? 1163 HOH A O   1 
HETATM 4889 O  O   . HOH G 5 .   ? 14.418 -13.665 -38.29  1    41.57  ? 1164 HOH A O   1 
HETATM 4890 O  O   . HOH G 5 .   ? -0.963 -15.924 -12.441 1    59.64  ? 1165 HOH A O   1 
HETATM 4891 O  O   . HOH G 5 .   ? 35.15  -20.167 0.709   1    54.46  ? 1166 HOH A O   1 
HETATM 4892 O  O   . HOH G 5 .   ? 32.857 -0.117  -13.321 1    58.66  ? 1167 HOH A O   1 
HETATM 4893 O  O   . HOH G 5 .   ? 0.087  -12.292 -24.134 1    39.83  ? 1168 HOH A O   1 
HETATM 4894 O  O   . HOH G 5 .   ? 16.315 -44.421 -11.562 1    35.4   ? 1169 HOH A O   1 
HETATM 4895 O  O   . HOH G 5 .   ? 19.055 -28.904 14.368  1    59.96  ? 1170 HOH A O   1 
HETATM 4896 O  O   . HOH G 5 .   ? 28.215 -33.356 5.789   1    46.36  ? 1171 HOH A O   1 
HETATM 4897 O  O   . HOH G 5 .   ? 2.414  -15.927 -38.883 1    49.4   ? 1172 HOH A O   1 
HETATM 4898 O  O   . HOH G 5 .   ? 15.773 -44.599 -20.576 0.50 69.01  ? 1173 HOH A O   1 
HETATM 4899 O  O   . HOH G 5 .   ? 34.533 -52.226 2.258   1    54.3   ? 1174 HOH A O   1 
HETATM 4900 O  O   . HOH G 5 .   ? 12.389 -57.6   12.31   1    48.41  ? 1175 HOH A O   1 
HETATM 4901 O  O   . HOH G 5 .   ? 0.125  -14.364 -37.556 1    67.12  ? 1176 HOH A O   1 
HETATM 4902 O  O   . HOH G 5 .   ? 29.589 -51.720 -4.184  1    45.5   ? 1177 HOH A O   1 
HETATM 4903 O  O   . HOH G 5 .   ? -0.540 -20.503 2.777   1    39.81  ? 1178 HOH A O   1 
HETATM 4904 O  O   . HOH G 5 .   ? 11.91  -39.584 -5.819  1    41.27  ? 1179 HOH A O   1 
HETATM 4905 O  O   . HOH G 5 .   ? 17.325 -10.574 -11.527 1    52.64  ? 1180 HOH A O   1 
HETATM 4906 O  O   . HOH G 5 .   ? 15.855 -59.153 12.729  1    46.95  ? 1181 HOH A O   1 
HETATM 4907 O  O   . HOH G 5 .   ? 17.865 -68.028 -10.859 1    55.46  ? 1182 HOH A O   1 
HETATM 4908 O  O   . HOH G 5 .   ? -0.252 -23.951 -6.956  1    57.43  ? 1183 HOH A O   1 
HETATM 4909 O  O   . HOH G 5 .   ? 25.642 -18.618 -36.543 1    65.03  ? 1184 HOH A O   1 
HETATM 4910 O  O   . HOH G 5 .   ? 6.5    -58.494 2.848   1    42.75  ? 1185 HOH A O   1 
HETATM 4911 O  O   . HOH G 5 .   ? 17.932 -29.815 21.425  1    72.58  ? 1186 HOH A O   1 
HETATM 4912 O  O   . HOH G 5 .   ? -2.897 -16.577 -14.026 1    55.59  ? 1187 HOH A O   1 
HETATM 4913 O  O   . HOH G 5 .   ? 24.015 -24.185 -35.796 1    42.85  ? 1188 HOH A O   1 
HETATM 4914 O  O   . HOH G 5 .   ? 16.921 -34.848 -3.062  1    38.49  ? 1189 HOH A O   1 
HETATM 4915 O  O   . HOH G 5 .   ? 36.566 -5.028  -1.336  1    62.28  ? 1190 HOH A O   1 
HETATM 4916 O  O   . HOH G 5 .   ? 10.472 -53.37  15.842  1    65.98  ? 1191 HOH A O   1 
HETATM 4917 O  O   . HOH G 5 .   ? 13.059 -53.98  -4.692  1    53.97  ? 1192 HOH A O   1 
HETATM 4918 O  O   . HOH G 5 .   ? 10.701 -10.497 -28.856 1    44.57  ? 1193 HOH A O   1 
HETATM 4919 O  O   . HOH G 5 .   ? 31.716 -29.258 -35.225 1    55.71  ? 1194 HOH A O   1 
HETATM 4920 O  O   . HOH G 5 .   ? 0.52   -8.08   -29.802 1    58.67  ? 1195 HOH A O   1 
HETATM 4921 O  O   . HOH G 5 .   ? 20.085 -13.964 -36.492 1    46.56  ? 1196 HOH A O   1 
HETATM 4922 O  O   . HOH G 5 .   ? 27.781 -42.832 -3.884  1    35.41  ? 1197 HOH A O   1 
HETATM 4923 O  O   . HOH G 5 .   ? 5.186  -61.083 13.364  1    55.91  ? 1198 HOH A O   1 
HETATM 4924 O  O   . HOH G 5 .   ? 21.417 -30.146 3.827   1    40.13  ? 1199 HOH A O   1 
HETATM 4925 O  O   . HOH G 5 .   ? 27.122 -0.178  -29.433 1    48.14  ? 1200 HOH A O   1 
HETATM 4926 O  O   . HOH G 5 .   ? 36.286 -23.288 -15.057 1    44.95  ? 1201 HOH A O   1 
HETATM 4927 O  O   . HOH G 5 .   ? 17.01  -42.059 26.021  1    47.89  ? 1202 HOH A O   1 
HETATM 4928 O  O   . HOH G 5 .   ? 17.052 -8.456  -7.531  1    66.98  ? 1203 HOH A O   1 
HETATM 4929 O  O   . HOH G 5 .   ? 17.261 -33.625 24.524  1    53.46  ? 1204 HOH A O   1 
HETATM 4930 O  O   . HOH G 5 .   ? 25.9   -36.015 -0.814  1    42.16  ? 1205 HOH A O   1 
HETATM 4931 O  O   . HOH G 5 .   ? 34.961 -52.148 27.412  1    73.93  ? 1206 HOH A O   1 
HETATM 4932 O  O   . HOH G 5 .   ? 25.492 -38.075 -34.792 1    56.1   ? 1207 HOH A O   1 
HETATM 4933 O  O   . HOH G 5 .   ? 17.175 -40.817 -32.217 1    48.98  ? 1208 HOH A O   1 
HETATM 4934 O  O   . HOH G 5 .   ? 32.684 -27.9   -11.834 1    51.25  ? 1209 HOH A O   1 
HETATM 4935 O  O   . HOH G 5 .   ? 21.629 -32.457 7.809   1    47.84  ? 1210 HOH A O   1 
HETATM 4936 O  O   . HOH G 5 .   ? 9.969  -58.019 -6.984  1    60.76  ? 1211 HOH A O   1 
HETATM 4937 O  O   . HOH G 5 .   ? 41.226 -55.857 9.728   1    59.71  ? 1212 HOH A O   1 
HETATM 4938 O  O   . HOH G 5 .   ? 36.17  -58.458 22.659  1    57.61  ? 1213 HOH A O   1 
HETATM 4939 O  O   . HOH G 5 .   ? 13.293 -55.361 16.535  1    56.41  ? 1214 HOH A O   1 
HETATM 4940 O  O   . HOH G 5 .   ? 15.350 -48.058 -14.230 1    57.15  ? 1215 HOH A O   1 
HETATM 4941 O  O   . HOH G 5 .   ? 12.574 -44.426 -19.807 1    63.63  ? 1216 HOH A O   1 
HETATM 4942 O  O   . HOH G 5 .   ? 6.536  -39.081 -6.338  1    78.24  ? 1217 HOH A O   1 
HETATM 4943 O  O   . HOH G 5 .   ? 10.569 -12.164 -26.608 1    53.41  ? 1218 HOH A O   1 
HETATM 4944 O  O   . HOH G 5 .   ? 27.328 -27.423 11.295  1    72.99  ? 1219 HOH A O   1 
HETATM 4945 O  O   . HOH G 5 .   ? -0.729 -31.695 -22.225 1    41.12  ? 1220 HOH A O   1 
HETATM 4946 O  O   . HOH G 5 .   ? 17.734 -62.692 -14.502 1    56.22  ? 1221 HOH A O   1 
HETATM 4947 O  O   . HOH G 5 .   ? 19.259 -6.285  -35.114 1    40.29  ? 1222 HOH A O   1 
HETATM 4948 O  O   . HOH G 5 .   ? 22.142 -25.846 -37.185 1    41.35  ? 1223 HOH A O   1 
HETATM 4949 O  O   . HOH G 5 .   ? 12.884 -42.781 25.957  1    59.27  ? 1224 HOH A O   1 
HETATM 4950 O  O   . HOH G 5 .   ? 7.584  -38.598 14.836  1    62.87  ? 1225 HOH A O   1 
HETATM 4951 O  O   . HOH G 5 .   ? 16.507 -72.642 -7.796  1    59.61  ? 1226 HOH A O   1 
HETATM 4952 O  O   . HOH G 5 .   ? 21.208 -58.643 9.244   1    47.34  ? 1227 HOH A O   1 
HETATM 4953 O  O   . HOH G 5 .   ? 29.939 -26.072 -0.917  1    50.86  ? 1228 HOH A O   1 
HETATM 4954 O  O   . HOH G 5 .   ? 36.492 -9.731  -30.286 1    64.19  ? 1229 HOH A O   1 
HETATM 4955 O  O   . HOH G 5 .   ? 4.767  -36.44  -6.867  1    46.6   ? 1230 HOH A O   1 
HETATM 4956 O  O   . HOH G 5 .   ? 13.576 -65.244 -11.82  1    52.57  ? 1231 HOH A O   1 
HETATM 4957 O  O   . HOH G 5 .   ? 1.587  -30.414 -12.589 1    34.96  ? 1232 HOH A O   1 
HETATM 4958 O  O   . HOH G 5 .   ? 4.225  -64.327 -0.789  1    66.09  ? 1233 HOH A O   1 
HETATM 4959 O  O   . HOH G 5 .   ? 9.106  -46.085 12.112  1    41.97  ? 1234 HOH A O   1 
HETATM 4960 O  O   . HOH G 5 .   ? -3.53  -19.686 -11.833 1    49.17  ? 1235 HOH A O   1 
HETATM 4961 O  O   . HOH G 5 .   ? 12.931 -48.333 -2.314  1    40.55  ? 1236 HOH A O   1 
HETATM 4962 O  O   . HOH G 5 .   ? -4.630 -29.438 -17.540 1    68.54  ? 1237 HOH A O   1 
HETATM 4963 O  O   . HOH G 5 .   ? 18.149 -13.326 -39.352 1    60.37  ? 1238 HOH A O   1 
HETATM 4964 O  O   . HOH G 5 .   ? 36.701 -40.418 5.987   1    59.37  ? 1239 HOH A O   1 
HETATM 4965 O  O   . HOH G 5 .   ? 34.147 -27.083 -6.536  1    54.84  ? 1240 HOH A O   1 
HETATM 4966 O  O   . HOH G 5 .   ? 5.79   -5.129  -12.16  1    56.25  ? 1241 HOH A O   1 
HETATM 4967 O  O   . HOH G 5 .   ? 21.731 -15.312 7.35    1    60.08  ? 1242 HOH A O   1 
HETATM 4968 O  O   . HOH G 5 .   ? 13.436 4.408   -20.268 1    68.15  ? 1243 HOH A O   1 
HETATM 4969 O  O   . HOH G 5 .   ? -3.863 -23.945 -14.132 1    39.18  ? 1244 HOH A O   1 
HETATM 4970 O  O   . HOH G 5 .   ? 5.036  -10.085 -38.06  1    54.85  ? 1245 HOH A O   1 
HETATM 4971 O  O   . HOH G 5 .   ? 20.686 -40.337 -33.308 1    45.57  ? 1246 HOH A O   1 
HETATM 4972 O  O   . HOH G 5 .   ? 12.866 -13.417 -26.981 1    48.25  ? 1247 HOH A O   1 
HETATM 4973 O  O   . HOH G 5 .   ? 8.665  -63.756 15.044  1    51.51  ? 1248 HOH A O   1 
HETATM 4974 O  O   . HOH G 5 .   ? 19.135 -35.394 25.277  1    52.18  ? 1249 HOH A O   1 
HETATM 4975 O  O   . HOH G 5 .   ? 0.668  -68.166 14.684  1    52.1   ? 1250 HOH A O   1 
HETATM 4976 O  O   . HOH G 5 .   ? 23.098 -34.256 2.035   1    35.68  ? 1251 HOH A O   1 
HETATM 4977 O  O   . HOH G 5 .   ? 12.188 -45.21  -17.235 1    59.73  ? 1252 HOH A O   1 
HETATM 4978 O  O   . HOH G 5 .   ? 2.732  -60.923 5.251   1    69.39  ? 1253 HOH A O   1 
HETATM 4979 O  O   . HOH G 5 .   ? 36.254 -30.244 -32.869 1    45.28  ? 1254 HOH A O   1 
HETATM 4980 O  O   . HOH G 5 .   ? 35.255 -22.297 -0.962  1    65.44  ? 1255 HOH A O   1 
HETATM 4981 O  O   . HOH G 5 .   ? 11.674 -52.991 12.862  1    75.25  ? 1256 HOH A O   1 
HETATM 4982 O  O   . HOH G 5 .   ? 0.712  -75.798 14.147  1    54.58  ? 1257 HOH A O   1 
HETATM 4983 O  O   . HOH G 5 .   ? 30.545 -45.683 -0.435  1    53.14  ? 1258 HOH A O   1 
HETATM 4984 O  O   . HOH G 5 .   ? 10.302 -42.413 13.411  1    43.34  ? 1259 HOH A O   1 
HETATM 4985 O  O   . HOH G 5 .   ? 9.929  -61.289 13.793  1    41.04  ? 1260 HOH A O   1 
HETATM 4986 O  O   . HOH G 5 .   ? 4.556  -62.538 1.177   1    54.09  ? 1261 HOH A O   1 
HETATM 4987 O  O   . HOH G 5 .   ? 23.13  -20.487 -36.626 1    42.53  ? 1262 HOH A O   1 
HETATM 4988 O  O   . HOH G 5 .   ? -2.425 -71.17  4.113   1    63.54  ? 1263 HOH A O   1 
HETATM 4989 O  O   . HOH G 5 .   ? -3.545 -31.712 -21.043 1    58.17  ? 1264 HOH A O   1 
HETATM 4990 O  O   . HOH G 5 .   ? 5.115  -56.398 -4.178  1    65.6   ? 1265 HOH A O   1 
HETATM 4991 O  O   . HOH G 5 .   ? 21.067 -65.969 9.933   1    58.53  ? 1266 HOH A O   1 
HETATM 4992 O  O   . HOH G 5 .   ? 9.381  -39.713 -6.768  1    46.85  ? 1267 HOH A O   1 
HETATM 4993 O  O   . HOH G 5 .   ? 21.794 -15.895 -37.319 1    67.38  ? 1268 HOH A O   1 
HETATM 4994 O  O   . HOH G 5 .   ? 25.7   -23.765 -37.719 1    54.74  ? 1269 HOH A O   1 
HETATM 4995 O  O   . HOH G 5 .   ? 8.58   -11.726 -22.417 1    50.85  ? 1270 HOH A O   1 
HETATM 4996 O  O   . HOH G 5 .   ? 22.238 -63.781 8.71    1    47.41  ? 1271 HOH A O   1 
HETATM 4997 O  O   . HOH G 5 .   ? -1.186 -20.599 -10.227 1    53     ? 1272 HOH A O   1 
HETATM 4998 O  O   . HOH G 5 .   ? 24.304 -5.025  -32.051 1    60.13  ? 1273 HOH A O   1 
HETATM 4999 O  O   . HOH G 5 .   ? 38.525 -59.045 18.796  1    53.68  ? 1274 HOH A O   1 
HETATM 5000 O  O   . HOH G 5 .   ? 24.1   -33.1   4.501   1    42.21  ? 1275 HOH A O   1 
HETATM 5001 O  O   . HOH G 5 .   ? 10.886 -10.432 -24.309 1    44.9   ? 1276 HOH A O   1 
HETATM 5002 O  O   . HOH G 5 .   ? 12.46  -70     -6.753  1    50.29  ? 1277 HOH A O   1 
HETATM 5003 O  O   . HOH G 5 .   ? 22.120 -41.964 -32.754 1    52.44  ? 1278 HOH A O   1 
HETATM 5004 O  O   . HOH G 5 .   ? 38.953 -24.185 -34.684 1    59.38  ? 1279 HOH A O   1 
HETATM 5005 O  O   . HOH G 5 .   ? 26.615 -19.762 5.805   1    40.74  ? 1280 HOH A O   1 
HETATM 5006 O  O   . HOH G 5 .   ? 31.983 -8.464  -32.873 1    55.82  ? 1281 HOH A O   1 
HETATM 5007 O  O   . HOH G 5 .   ? 27.823 -26.527 14.923  1    57.65  ? 1282 HOH A O   1 
HETATM 5008 O  O   . HOH G 5 .   ? 11.469 -38.951 -23.483 1    44.09  ? 1283 HOH A O   1 
HETATM 5009 O  O   . HOH G 5 .   ? 0.203  -10.444 -33.491 1    56.35  ? 1284 HOH A O   1 
HETATM 5010 O  O   . HOH G 5 .   ? -7.807 -17.746 -18.300 1    57.97  ? 1285 HOH A O   1 
HETATM 5011 O  O   . HOH G 5 .   ? 15.026 -68.348 -7.915  1    43.62  ? 1286 HOH A O   1 
HETATM 5012 O  O   . HOH G 5 .   ? 8.089  -35.041 -4.531  1    38.95  ? 1287 HOH A O   1 
HETATM 5013 O  O   . HOH G 5 .   ? 0.41   -10.263 -22.258 1    51.24  ? 1288 HOH A O   1 
HETATM 5014 O  O   . HOH G 5 .   ? -5.237 -21.683 -12.937 1    52.41  ? 1289 HOH A O   1 
HETATM 5015 O  O   . HOH G 5 .   ? 25.657 -35.666 -35.923 1    63.07  ? 1290 HOH A O   1 
HETATM 5016 O  O   . HOH G 5 .   ? 9.273  -8.43   -38.392 1    56.73  ? 1291 HOH A O   1 
HETATM 5017 O  O   . HOH G 5 .   ? 10.622 -30.99  3.817   1    57.99  ? 1292 HOH A O   1 
HETATM 5018 O  O   . HOH G 5 .   ? 19.301 -27.823 11.964  1    53.93  ? 1293 HOH A O   1 
HETATM 5019 O  O   . HOH G 5 .   ? -0.323 -12.79  -30.611 1    49.95  ? 1294 HOH A O   1 
HETATM 5020 O  O   . HOH G 5 .   ? -1.799 -8.605  -32.86  1    57.9   ? 1295 HOH A O   1 
HETATM 5021 O  O   . HOH G 5 .   ? 9.05   -9.252  -27.646 1    51.67  ? 1296 HOH A O   1 
HETATM 5022 O  O   . HOH G 5 .   ? 21.664 -32.441 5.069   1    49     ? 1297 HOH A O   1 
HETATM 5023 O  O   . HOH G 5 .   ? 30.999 -17.908 6.012   1    47.51  ? 1298 HOH A O   1 
HETATM 5024 O  O   . HOH G 5 .   ? 37.6   -23.922 -17.217 1    46.93  ? 1299 HOH A O   1 
HETATM 5025 O  O   . HOH G 5 .   ? 4.696  -7.751  -7.648  1    56.24  ? 1300 HOH A O   1 
HETATM 5026 O  O   . HOH G 5 .   ? 12.235 -35.311 -4.092  1    36.18  ? 1301 HOH A O   1 
HETATM 5027 O  O   . HOH G 5 .   ? 26.583 -2.635  -29.719 1    48.19  ? 1302 HOH A O   1 
HETATM 5028 O  O   . HOH G 5 .   ? 38.183 -11.415 -28.489 1    51.79  ? 1303 HOH A O   1 
HETATM 5029 O  O   . HOH G 5 .   ? -8.501 -19.415 -20.406 1    67.45  ? 1304 HOH A O   1 
HETATM 5030 O  O   . HOH G 5 .   ? 25.418 -36.485 -7.291  1    46.54  ? 1305 HOH A O   1 
HETATM 5031 O  O   . HOH G 5 .   ? 23.356 -37.558 -6.037  1    53.61  ? 1306 HOH A O   1 
HETATM 5032 O  O   . HOH G 5 .   ? 3.017  -67.281 1.25    1    59.64  ? 1307 HOH A O   1 
HETATM 5033 O  O   . HOH G 5 .   ? 8.38   -37.61  -5.129  1    47.58  ? 1308 HOH A O   1 
HETATM 5034 O  O   . HOH G 5 .   ? 8.208  -47.6   10.064  1    61.28  ? 1309 HOH A O   1 
HETATM 5035 O  O   . HOH G 5 .   ? 7.26   -34.644 -2.07   1    53.02  ? 1310 HOH A O   1 
HETATM 5036 O  O   . HOH G 5 .   ? 25.347 -30.628 4.116   1    56.67  ? 1311 HOH A O   1 
HETATM 5037 O  O   . HOH G 5 .   ? 0.627  -10.98  -36.15  1    59.62  ? 1312 HOH A O   1 
HETATM 5038 O  O   . HOH G 5 .   ? 25.818 -22.965 6.253   1    59.62  ? 1313 HOH A O   1 
HETATM 5039 O  O   . HOH G 5 .   ? 36.179 -24.658 -39.601 1    57.9   ? 1314 HOH A O   1 
HETATM 5040 O  O   . HOH G 5 .   ? 27.55  -24.729 12.573  1    63.97  ? 1315 HOH A O   1 
HETATM 5041 O  O   . HOH G 5 .   ? 11.255 -36.706 -1.775  1    48.41  ? 1316 HOH A O   1 
HETATM 5042 O  O   . HOH G 5 .   ? 8.107  -4.252  -4.659  1    60     ? 1317 HOH A O   1 
HETATM 5043 O  O   . HOH G 5 .   ? 15.916 -62.933 20.518  0.50 93.53  ? 1318 HOH A O   1 
HETATM 5044 O  O   . HOH G 5 .   ? 11.596 -20.9   9.542   1    63.48  ? 1319 HOH A O   1 
# 
