data_9EWS
# 
_entry.id   9EWS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9EWS         pdb_00009ews 10.2210/pdb9ews/pdb 
WWPDB D_1292137701 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-06 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9EWS 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              David.Hargreaves@astrazeneca.com 
_pdbx_contact_author.name_first         David 
_pdbx_contact_author.name_last          Hargreaves 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-4441-0039 
# 
_audit_author.name               'Hargreaves, D.' 
_audit_author.pdbx_ordinal       1 
_audit_author.identifier_ORCID   0000-0003-4441-0039 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Med.Chem. 
_citation.journal_id_ASTM           JMCMAR 
_citation.journal_id_CSD            0151 
_citation.journal_id_ISSN           0022-2623 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
;Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations.
;
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.jmedchem.4c01792 
_citation.pdbx_database_id_PubMed   39340451 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Thomson, C.'      1  0000-0003-3160-1397 
primary 'Braybrooke, E.'   2  ?                   
primary 'Colclough, N.'    3  ?                   
primary 'Davies, N.L.'     4  ?                   
primary 
;Floc'h, N.
;
5  ?                   
primary 'Greenwood, R.'    6  ?                   
primary 'Guerot, C.'       7  ?                   
primary 'Hargreaves, D.'   8  ?                   
primary 'Johnstrom, P.'    9  ?                   
primary 'Khurana, P.'      10 ?                   
primary 'Kostomiris, D.H.' 11 ?                   
primary 'Li, S.'           12 ?                   
primary 'Lister, A.'       13 ?                   
primary 'Lorthioir, O.'    14 ?                   
primary 'Martin, S.'       15 ?                   
primary 'McCoull, W.'      16 0000-0002-2977-1744 
primary 'McLean, N.J.'     17 ?                   
primary 'McWilliams, L.'   18 ?                   
primary 'Orme, J.P.'       19 ?                   
primary 'Packer, M.J.'     20 ?                   
primary 'Pearson, S.'      21 ?                   
primary 'Swaih, A.M.'      22 ?                   
primary 'Tentarelli, S.'   23 0000-0003-2968-8120 
primary 'Tucker, M.J.'     24 ?                   
primary 'Ward, R.A.'       25 0000-0002-2310-9477 
primary 'Wilkinson, S.'    26 ?                   
primary 'Winlow, P.'       27 ?                   
primary 'Wood, I.L.'       28 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Epidermal growth factor receptor'                                                                            
37774.594 1  2.7.10.1 ? ? ? 
2 non-polymer syn '1-[3-pyridin-4-yl-2-[3-(2-pyrimidin-2-ylethynyl)phenyl]-4,6-dihydropyrrolo[3,4-d]imidazol-5-yl]propan-1-one' 
420.466   1  ?        ? ? ? 
3 non-polymer syn 'IODIDE ION'                                                                                                  
126.904   15 ?        ? ? ? 
4 water       nat water                                                                                                         
18.015    28 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPG
NPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKG
ERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDV
VDADEYLIPQQG
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPG
NPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKG
ERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDV
VDADEYLIPQQG
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '1-[3-pyridin-4-yl-2-[3-(2-pyrimidin-2-ylethynyl)phenyl]-4,6-dihydropyrrolo[3,4-d]imidazol-5-yl]propan-1-one' A1H7N 
3 'IODIDE ION'                                                                                                  IOD   
4 water                                                                                                         HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   GLY n 
1 4   GLU n 
1 5   ALA n 
1 6   PRO n 
1 7   ASN n 
1 8   GLN n 
1 9   ALA n 
1 10  LEU n 
1 11  LEU n 
1 12  ARG n 
1 13  ILE n 
1 14  LEU n 
1 15  LYS n 
1 16  GLU n 
1 17  THR n 
1 18  GLU n 
1 19  PHE n 
1 20  LYS n 
1 21  LYS n 
1 22  ILE n 
1 23  LYS n 
1 24  VAL n 
1 25  LEU n 
1 26  GLY n 
1 27  SER n 
1 28  GLY n 
1 29  ALA n 
1 30  PHE n 
1 31  GLY n 
1 32  THR n 
1 33  VAL n 
1 34  TYR n 
1 35  LYS n 
1 36  GLY n 
1 37  LEU n 
1 38  TRP n 
1 39  ILE n 
1 40  PRO n 
1 41  GLU n 
1 42  GLY n 
1 43  GLU n 
1 44  LYS n 
1 45  VAL n 
1 46  LYS n 
1 47  ILE n 
1 48  PRO n 
1 49  VAL n 
1 50  ALA n 
1 51  ILE n 
1 52  LYS n 
1 53  GLU n 
1 54  LEU n 
1 55  ARG n 
1 56  GLU n 
1 57  ALA n 
1 58  THR n 
1 59  SER n 
1 60  PRO n 
1 61  LYS n 
1 62  ALA n 
1 63  ASN n 
1 64  LYS n 
1 65  GLU n 
1 66  ILE n 
1 67  LEU n 
1 68  ASP n 
1 69  GLU n 
1 70  ALA n 
1 71  TYR n 
1 72  VAL n 
1 73  MET n 
1 74  ALA n 
1 75  SER n 
1 76  VAL n 
1 77  ASP n 
1 78  ASN n 
1 79  PRO n 
1 80  GLY n 
1 81  ASN n 
1 82  PRO n 
1 83  HIS n 
1 84  VAL n 
1 85  CYS n 
1 86  ARG n 
1 87  LEU n 
1 88  LEU n 
1 89  GLY n 
1 90  ILE n 
1 91  CYS n 
1 92  LEU n 
1 93  THR n 
1 94  SER n 
1 95  THR n 
1 96  VAL n 
1 97  GLN n 
1 98  LEU n 
1 99  ILE n 
1 100 THR n 
1 101 GLN n 
1 102 LEU n 
1 103 MET n 
1 104 PRO n 
1 105 PHE n 
1 106 GLY n 
1 107 CYS n 
1 108 LEU n 
1 109 LEU n 
1 110 ASP n 
1 111 TYR n 
1 112 VAL n 
1 113 ARG n 
1 114 GLU n 
1 115 HIS n 
1 116 LYS n 
1 117 ASP n 
1 118 ASN n 
1 119 ILE n 
1 120 GLY n 
1 121 SER n 
1 122 GLN n 
1 123 TYR n 
1 124 LEU n 
1 125 LEU n 
1 126 ASN n 
1 127 TRP n 
1 128 CYS n 
1 129 VAL n 
1 130 GLN n 
1 131 ILE n 
1 132 ALA n 
1 133 LYS n 
1 134 GLY n 
1 135 MET n 
1 136 ASN n 
1 137 TYR n 
1 138 LEU n 
1 139 GLU n 
1 140 ASP n 
1 141 ARG n 
1 142 ARG n 
1 143 LEU n 
1 144 VAL n 
1 145 HIS n 
1 146 ARG n 
1 147 ASP n 
1 148 LEU n 
1 149 ALA n 
1 150 ALA n 
1 151 ARG n 
1 152 ASN n 
1 153 VAL n 
1 154 LEU n 
1 155 VAL n 
1 156 LYS n 
1 157 THR n 
1 158 PRO n 
1 159 GLN n 
1 160 HIS n 
1 161 VAL n 
1 162 LYS n 
1 163 ILE n 
1 164 THR n 
1 165 ASP n 
1 166 PHE n 
1 167 GLY n 
1 168 LEU n 
1 169 ALA n 
1 170 LYS n 
1 171 LEU n 
1 172 LEU n 
1 173 GLY n 
1 174 ALA n 
1 175 GLU n 
1 176 GLU n 
1 177 LYS n 
1 178 GLU n 
1 179 TYR n 
1 180 HIS n 
1 181 ALA n 
1 182 GLU n 
1 183 GLY n 
1 184 GLY n 
1 185 LYS n 
1 186 VAL n 
1 187 PRO n 
1 188 ILE n 
1 189 LYS n 
1 190 TRP n 
1 191 MET n 
1 192 ALA n 
1 193 LEU n 
1 194 GLU n 
1 195 SER n 
1 196 ILE n 
1 197 LEU n 
1 198 HIS n 
1 199 ARG n 
1 200 ILE n 
1 201 TYR n 
1 202 THR n 
1 203 HIS n 
1 204 GLN n 
1 205 SER n 
1 206 ASP n 
1 207 VAL n 
1 208 TRP n 
1 209 SER n 
1 210 TYR n 
1 211 GLY n 
1 212 VAL n 
1 213 THR n 
1 214 VAL n 
1 215 TRP n 
1 216 GLU n 
1 217 LEU n 
1 218 MET n 
1 219 THR n 
1 220 PHE n 
1 221 GLY n 
1 222 SER n 
1 223 LYS n 
1 224 PRO n 
1 225 TYR n 
1 226 ASP n 
1 227 GLY n 
1 228 ILE n 
1 229 PRO n 
1 230 ALA n 
1 231 SER n 
1 232 GLU n 
1 233 ILE n 
1 234 SER n 
1 235 SER n 
1 236 ILE n 
1 237 LEU n 
1 238 GLU n 
1 239 LYS n 
1 240 GLY n 
1 241 GLU n 
1 242 ARG n 
1 243 LEU n 
1 244 PRO n 
1 245 GLN n 
1 246 PRO n 
1 247 PRO n 
1 248 ILE n 
1 249 CYS n 
1 250 THR n 
1 251 ILE n 
1 252 ASP n 
1 253 VAL n 
1 254 TYR n 
1 255 MET n 
1 256 ILE n 
1 257 MET n 
1 258 ARG n 
1 259 LYS n 
1 260 CYS n 
1 261 TRP n 
1 262 MET n 
1 263 ILE n 
1 264 ASP n 
1 265 ALA n 
1 266 ASP n 
1 267 SER n 
1 268 ARG n 
1 269 PRO n 
1 270 LYS n 
1 271 PHE n 
1 272 ARG n 
1 273 GLU n 
1 274 LEU n 
1 275 ILE n 
1 276 ILE n 
1 277 GLU n 
1 278 PHE n 
1 279 SER n 
1 280 LYS n 
1 281 MET n 
1 282 ALA n 
1 283 ARG n 
1 284 ASP n 
1 285 PRO n 
1 286 GLN n 
1 287 ARG n 
1 288 TYR n 
1 289 LEU n 
1 290 VAL n 
1 291 ILE n 
1 292 GLN n 
1 293 GLY n 
1 294 ASP n 
1 295 GLU n 
1 296 ARG n 
1 297 MET n 
1 298 HIS n 
1 299 LEU n 
1 300 PRO n 
1 301 SER n 
1 302 PRO n 
1 303 THR n 
1 304 ASP n 
1 305 SER n 
1 306 ASN n 
1 307 PHE n 
1 308 TYR n 
1 309 ARG n 
1 310 ALA n 
1 311 LEU n 
1 312 MET n 
1 313 ASP n 
1 314 GLU n 
1 315 GLU n 
1 316 ASP n 
1 317 MET n 
1 318 ASP n 
1 319 ASP n 
1 320 VAL n 
1 321 VAL n 
1 322 ASP n 
1 323 ALA n 
1 324 ASP n 
1 325 GLU n 
1 326 TYR n 
1 327 LEU n 
1 328 ILE n 
1 329 PRO n 
1 330 GLN n 
1 331 GLN n 
1 332 GLY n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   332 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'EGFR, ERBB, ERBB1, HER1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1H7N non-polymer         . 
'1-[3-pyridin-4-yl-2-[3-(2-pyrimidin-2-ylethynyl)phenyl]-4,6-dihydropyrrolo[3,4-d]imidazol-5-yl]propan-1-one' ? 'C25 H20 N6 O'   
420.466 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
IOD   non-polymer         . 'IODIDE ION' ? 'I -1'           126.904 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   694  ?   ?   ?   A . n 
A 1 2   SER 2   695  ?   ?   ?   A . n 
A 1 3   GLY 3   696  ?   ?   ?   A . n 
A 1 4   GLU 4   697  ?   ?   ?   A . n 
A 1 5   ALA 5   698  ?   ?   ?   A . n 
A 1 6   PRO 6   699  ?   ?   ?   A . n 
A 1 7   ASN 7   700  ?   ?   ?   A . n 
A 1 8   GLN 8   701  ?   ?   ?   A . n 
A 1 9   ALA 9   702  ?   ?   ?   A . n 
A 1 10  LEU 10  703  703 LEU LEU A . n 
A 1 11  LEU 11  704  704 LEU LEU A . n 
A 1 12  ARG 12  705  705 ARG ARG A . n 
A 1 13  ILE 13  706  706 ILE ILE A . n 
A 1 14  LEU 14  707  707 LEU LEU A . n 
A 1 15  LYS 15  708  708 LYS LYS A . n 
A 1 16  GLU 16  709  709 GLU GLU A . n 
A 1 17  THR 17  710  710 THR THR A . n 
A 1 18  GLU 18  711  711 GLU GLU A . n 
A 1 19  PHE 19  712  712 PHE PHE A . n 
A 1 20  LYS 20  713  713 LYS LYS A . n 
A 1 21  LYS 21  714  714 LYS LYS A . n 
A 1 22  ILE 22  715  715 ILE ILE A . n 
A 1 23  LYS 23  716  716 LYS LYS A . n 
A 1 24  VAL 24  717  717 VAL VAL A . n 
A 1 25  LEU 25  718  718 LEU LEU A . n 
A 1 26  GLY 26  719  719 GLY GLY A . n 
A 1 27  SER 27  720  720 SER SER A . n 
A 1 28  GLY 28  721  721 GLY GLY A . n 
A 1 29  ALA 29  722  722 ALA ALA A . n 
A 1 30  PHE 30  723  723 PHE PHE A . n 
A 1 31  GLY 31  724  724 GLY GLY A . n 
A 1 32  THR 32  725  725 THR THR A . n 
A 1 33  VAL 33  726  726 VAL VAL A . n 
A 1 34  TYR 34  727  727 TYR TYR A . n 
A 1 35  LYS 35  728  728 LYS LYS A . n 
A 1 36  GLY 36  729  729 GLY GLY A . n 
A 1 37  LEU 37  730  730 LEU LEU A . n 
A 1 38  TRP 38  731  731 TRP TRP A . n 
A 1 39  ILE 39  732  732 ILE ILE A . n 
A 1 40  PRO 40  733  733 PRO PRO A . n 
A 1 41  GLU 41  734  734 GLU GLU A . n 
A 1 42  GLY 42  735  735 GLY GLY A . n 
A 1 43  GLU 43  736  736 GLU GLU A . n 
A 1 44  LYS 44  737  737 LYS LYS A . n 
A 1 45  VAL 45  738  738 VAL VAL A . n 
A 1 46  LYS 46  739  739 LYS LYS A . n 
A 1 47  ILE 47  740  740 ILE ILE A . n 
A 1 48  PRO 48  741  741 PRO PRO A . n 
A 1 49  VAL 49  742  742 VAL VAL A . n 
A 1 50  ALA 50  743  743 ALA ALA A . n 
A 1 51  ILE 51  744  744 ILE ILE A . n 
A 1 52  LYS 52  745  745 LYS LYS A . n 
A 1 53  GLU 53  746  746 GLU GLU A . n 
A 1 54  LEU 54  747  747 LEU LEU A . n 
A 1 55  ARG 55  748  748 ARG ARG A . n 
A 1 56  GLU 56  749  749 GLU GLU A . n 
A 1 57  ALA 57  750  750 ALA ALA A . n 
A 1 58  THR 58  751  751 THR THR A . n 
A 1 59  SER 59  752  752 SER SER A . n 
A 1 60  PRO 60  753  753 PRO PRO A . n 
A 1 61  LYS 61  754  754 LYS LYS A . n 
A 1 62  ALA 62  755  755 ALA ALA A . n 
A 1 63  ASN 63  756  756 ASN ASN A . n 
A 1 64  LYS 64  757  757 LYS LYS A . n 
A 1 65  GLU 65  758  758 GLU GLU A . n 
A 1 66  ILE 66  759  759 ILE ILE A . n 
A 1 67  LEU 67  760  760 LEU LEU A . n 
A 1 68  ASP 68  761  761 ASP ASP A . n 
A 1 69  GLU 69  762  762 GLU GLU A . n 
A 1 70  ALA 70  763  763 ALA ALA A . n 
A 1 71  TYR 71  764  764 TYR TYR A . n 
A 1 72  VAL 72  765  765 VAL VAL A . n 
A 1 73  MET 73  766  766 MET MET A . n 
A 1 74  ALA 74  767  767 ALA ALA A . n 
A 1 75  SER 75  768  768 SER SER A . n 
A 1 76  VAL 76  769  769 VAL VAL A . n 
A 1 77  ASP 77  770  770 ASP ASP A . n 
A 1 78  ASN 78  771  771 ASN ASN A . n 
A 1 79  PRO 79  772  772 PRO PRO A . n 
A 1 80  GLY 80  773  773 GLY GLY A . n 
A 1 81  ASN 81  774  774 ASN ASN A . n 
A 1 82  PRO 82  775  775 PRO PRO A . n 
A 1 83  HIS 83  776  776 HIS HIS A . n 
A 1 84  VAL 84  777  777 VAL VAL A . n 
A 1 85  CYS 85  778  778 CYS CYS A . n 
A 1 86  ARG 86  779  779 ARG ARG A . n 
A 1 87  LEU 87  780  780 LEU LEU A . n 
A 1 88  LEU 88  781  781 LEU LEU A . n 
A 1 89  GLY 89  782  782 GLY GLY A . n 
A 1 90  ILE 90  783  783 ILE ILE A . n 
A 1 91  CYS 91  784  784 CYS CYS A . n 
A 1 92  LEU 92  785  785 LEU LEU A . n 
A 1 93  THR 93  786  786 THR THR A . n 
A 1 94  SER 94  787  787 SER SER A . n 
A 1 95  THR 95  788  788 THR THR A . n 
A 1 96  VAL 96  789  789 VAL VAL A . n 
A 1 97  GLN 97  790  790 GLN GLN A . n 
A 1 98  LEU 98  791  791 LEU LEU A . n 
A 1 99  ILE 99  792  792 ILE ILE A . n 
A 1 100 THR 100 793  793 THR THR A . n 
A 1 101 GLN 101 794  794 GLN GLN A . n 
A 1 102 LEU 102 795  795 LEU LEU A . n 
A 1 103 MET 103 796  796 MET MET A . n 
A 1 104 PRO 104 797  797 PRO PRO A . n 
A 1 105 PHE 105 798  798 PHE PHE A . n 
A 1 106 GLY 106 799  799 GLY GLY A . n 
A 1 107 CYS 107 800  800 CYS CYS A . n 
A 1 108 LEU 108 801  801 LEU LEU A . n 
A 1 109 LEU 109 802  802 LEU LEU A . n 
A 1 110 ASP 110 803  803 ASP ASP A . n 
A 1 111 TYR 111 804  804 TYR TYR A . n 
A 1 112 VAL 112 805  805 VAL VAL A . n 
A 1 113 ARG 113 806  806 ARG ARG A . n 
A 1 114 GLU 114 807  807 GLU GLU A . n 
A 1 115 HIS 115 808  808 HIS HIS A . n 
A 1 116 LYS 116 809  809 LYS LYS A . n 
A 1 117 ASP 117 810  810 ASP ASP A . n 
A 1 118 ASN 118 811  811 ASN ASN A . n 
A 1 119 ILE 119 812  812 ILE ILE A . n 
A 1 120 GLY 120 813  813 GLY GLY A . n 
A 1 121 SER 121 814  814 SER SER A . n 
A 1 122 GLN 122 815  815 GLN GLN A . n 
A 1 123 TYR 123 816  816 TYR TYR A . n 
A 1 124 LEU 124 817  817 LEU LEU A . n 
A 1 125 LEU 125 818  818 LEU LEU A . n 
A 1 126 ASN 126 819  819 ASN ASN A . n 
A 1 127 TRP 127 820  820 TRP TRP A . n 
A 1 128 CYS 128 821  821 CYS CYS A . n 
A 1 129 VAL 129 822  822 VAL VAL A . n 
A 1 130 GLN 130 823  823 GLN GLN A . n 
A 1 131 ILE 131 824  824 ILE ILE A . n 
A 1 132 ALA 132 825  825 ALA ALA A . n 
A 1 133 LYS 133 826  826 LYS LYS A . n 
A 1 134 GLY 134 827  827 GLY GLY A . n 
A 1 135 MET 135 828  828 MET MET A . n 
A 1 136 ASN 136 829  829 ASN ASN A . n 
A 1 137 TYR 137 830  830 TYR TYR A . n 
A 1 138 LEU 138 831  831 LEU LEU A . n 
A 1 139 GLU 139 832  832 GLU GLU A . n 
A 1 140 ASP 140 833  833 ASP ASP A . n 
A 1 141 ARG 141 834  834 ARG ARG A . n 
A 1 142 ARG 142 835  835 ARG ARG A . n 
A 1 143 LEU 143 836  836 LEU LEU A . n 
A 1 144 VAL 144 837  837 VAL VAL A . n 
A 1 145 HIS 145 838  838 HIS HIS A . n 
A 1 146 ARG 146 839  839 ARG ARG A . n 
A 1 147 ASP 147 840  840 ASP ASP A . n 
A 1 148 LEU 148 841  841 LEU LEU A . n 
A 1 149 ALA 149 842  842 ALA ALA A . n 
A 1 150 ALA 150 843  843 ALA ALA A . n 
A 1 151 ARG 151 844  844 ARG ARG A . n 
A 1 152 ASN 152 845  845 ASN ASN A . n 
A 1 153 VAL 153 846  846 VAL VAL A . n 
A 1 154 LEU 154 847  847 LEU LEU A . n 
A 1 155 VAL 155 848  848 VAL VAL A . n 
A 1 156 LYS 156 849  849 LYS LYS A . n 
A 1 157 THR 157 850  850 THR THR A . n 
A 1 158 PRO 158 851  851 PRO PRO A . n 
A 1 159 GLN 159 852  852 GLN GLN A . n 
A 1 160 HIS 160 853  853 HIS HIS A . n 
A 1 161 VAL 161 854  854 VAL VAL A . n 
A 1 162 LYS 162 855  855 LYS LYS A . n 
A 1 163 ILE 163 856  856 ILE ILE A . n 
A 1 164 THR 164 857  857 THR THR A . n 
A 1 165 ASP 165 858  858 ASP ASP A . n 
A 1 166 PHE 166 859  859 PHE PHE A . n 
A 1 167 GLY 167 860  860 GLY GLY A . n 
A 1 168 LEU 168 861  861 LEU LEU A . n 
A 1 169 ALA 169 862  862 ALA ALA A . n 
A 1 170 LYS 170 863  863 LYS LYS A . n 
A 1 171 LEU 171 864  864 LEU LEU A . n 
A 1 172 LEU 172 865  865 LEU LEU A . n 
A 1 173 GLY 173 866  866 GLY GLY A . n 
A 1 174 ALA 174 867  ?   ?   ?   A . n 
A 1 175 GLU 175 868  ?   ?   ?   A . n 
A 1 176 GLU 176 869  ?   ?   ?   A . n 
A 1 177 LYS 177 870  ?   ?   ?   A . n 
A 1 178 GLU 178 871  ?   ?   ?   A . n 
A 1 179 TYR 179 872  ?   ?   ?   A . n 
A 1 180 HIS 180 873  ?   ?   ?   A . n 
A 1 181 ALA 181 874  ?   ?   ?   A . n 
A 1 182 GLU 182 875  ?   ?   ?   A . n 
A 1 183 GLY 183 876  ?   ?   ?   A . n 
A 1 184 GLY 184 877  ?   ?   ?   A . n 
A 1 185 LYS 185 878  ?   ?   ?   A . n 
A 1 186 VAL 186 879  879 VAL VAL A . n 
A 1 187 PRO 187 880  880 PRO PRO A . n 
A 1 188 ILE 188 881  881 ILE ILE A . n 
A 1 189 LYS 189 882  882 LYS LYS A . n 
A 1 190 TRP 190 883  883 TRP TRP A . n 
A 1 191 MET 191 884  884 MET MET A . n 
A 1 192 ALA 192 885  885 ALA ALA A . n 
A 1 193 LEU 193 886  886 LEU LEU A . n 
A 1 194 GLU 194 887  887 GLU GLU A . n 
A 1 195 SER 195 888  888 SER SER A . n 
A 1 196 ILE 196 889  889 ILE ILE A . n 
A 1 197 LEU 197 890  890 LEU LEU A . n 
A 1 198 HIS 198 891  891 HIS HIS A . n 
A 1 199 ARG 199 892  892 ARG ARG A . n 
A 1 200 ILE 200 893  893 ILE ILE A . n 
A 1 201 TYR 201 894  894 TYR TYR A . n 
A 1 202 THR 202 895  895 THR THR A . n 
A 1 203 HIS 203 896  896 HIS HIS A . n 
A 1 204 GLN 204 897  897 GLN GLN A . n 
A 1 205 SER 205 898  898 SER SER A . n 
A 1 206 ASP 206 899  899 ASP ASP A . n 
A 1 207 VAL 207 900  900 VAL VAL A . n 
A 1 208 TRP 208 901  901 TRP TRP A . n 
A 1 209 SER 209 902  902 SER SER A . n 
A 1 210 TYR 210 903  903 TYR TYR A . n 
A 1 211 GLY 211 904  904 GLY GLY A . n 
A 1 212 VAL 212 905  905 VAL VAL A . n 
A 1 213 THR 213 906  906 THR THR A . n 
A 1 214 VAL 214 907  907 VAL VAL A . n 
A 1 215 TRP 215 908  908 TRP TRP A . n 
A 1 216 GLU 216 909  909 GLU GLU A . n 
A 1 217 LEU 217 910  910 LEU LEU A . n 
A 1 218 MET 218 911  911 MET MET A . n 
A 1 219 THR 219 912  912 THR THR A . n 
A 1 220 PHE 220 913  913 PHE PHE A . n 
A 1 221 GLY 221 914  914 GLY GLY A . n 
A 1 222 SER 222 915  915 SER SER A . n 
A 1 223 LYS 223 916  916 LYS LYS A . n 
A 1 224 PRO 224 917  917 PRO PRO A . n 
A 1 225 TYR 225 918  918 TYR TYR A . n 
A 1 226 ASP 226 919  919 ASP ASP A . n 
A 1 227 GLY 227 920  920 GLY GLY A . n 
A 1 228 ILE 228 921  921 ILE ILE A . n 
A 1 229 PRO 229 922  922 PRO PRO A . n 
A 1 230 ALA 230 923  923 ALA ALA A . n 
A 1 231 SER 231 924  924 SER SER A . n 
A 1 232 GLU 232 925  925 GLU GLU A . n 
A 1 233 ILE 233 926  926 ILE ILE A . n 
A 1 234 SER 234 927  927 SER SER A . n 
A 1 235 SER 235 928  928 SER SER A . n 
A 1 236 ILE 236 929  929 ILE ILE A . n 
A 1 237 LEU 237 930  930 LEU LEU A . n 
A 1 238 GLU 238 931  931 GLU GLU A . n 
A 1 239 LYS 239 932  932 LYS LYS A . n 
A 1 240 GLY 240 933  933 GLY GLY A . n 
A 1 241 GLU 241 934  934 GLU GLU A . n 
A 1 242 ARG 242 935  935 ARG ARG A . n 
A 1 243 LEU 243 936  936 LEU LEU A . n 
A 1 244 PRO 244 937  937 PRO PRO A . n 
A 1 245 GLN 245 938  938 GLN GLN A . n 
A 1 246 PRO 246 939  939 PRO PRO A . n 
A 1 247 PRO 247 940  940 PRO PRO A . n 
A 1 248 ILE 248 941  941 ILE ILE A . n 
A 1 249 CYS 249 942  942 CYS CYS A . n 
A 1 250 THR 250 943  943 THR THR A . n 
A 1 251 ILE 251 944  944 ILE ILE A . n 
A 1 252 ASP 252 945  945 ASP ASP A . n 
A 1 253 VAL 253 946  946 VAL VAL A . n 
A 1 254 TYR 254 947  947 TYR TYR A . n 
A 1 255 MET 255 948  948 MET MET A . n 
A 1 256 ILE 256 949  949 ILE ILE A . n 
A 1 257 MET 257 950  950 MET MET A . n 
A 1 258 ARG 258 951  951 ARG ARG A . n 
A 1 259 LYS 259 952  952 LYS LYS A . n 
A 1 260 CYS 260 953  953 CYS CYS A . n 
A 1 261 TRP 261 954  954 TRP TRP A . n 
A 1 262 MET 262 955  955 MET MET A . n 
A 1 263 ILE 263 956  956 ILE ILE A . n 
A 1 264 ASP 264 957  957 ASP ASP A . n 
A 1 265 ALA 265 958  958 ALA ALA A . n 
A 1 266 ASP 266 959  959 ASP ASP A . n 
A 1 267 SER 267 960  960 SER SER A . n 
A 1 268 ARG 268 961  961 ARG ARG A . n 
A 1 269 PRO 269 962  962 PRO PRO A . n 
A 1 270 LYS 270 963  963 LYS LYS A . n 
A 1 271 PHE 271 964  964 PHE PHE A . n 
A 1 272 ARG 272 965  965 ARG ARG A . n 
A 1 273 GLU 273 966  966 GLU GLU A . n 
A 1 274 LEU 274 967  967 LEU LEU A . n 
A 1 275 ILE 275 968  968 ILE ILE A . n 
A 1 276 ILE 276 969  969 ILE ILE A . n 
A 1 277 GLU 277 970  970 GLU GLU A . n 
A 1 278 PHE 278 971  971 PHE PHE A . n 
A 1 279 SER 279 972  972 SER SER A . n 
A 1 280 LYS 280 973  973 LYS LYS A . n 
A 1 281 MET 281 974  974 MET MET A . n 
A 1 282 ALA 282 975  975 ALA ALA A . n 
A 1 283 ARG 283 976  976 ARG ARG A . n 
A 1 284 ASP 284 977  977 ASP ASP A . n 
A 1 285 PRO 285 978  978 PRO PRO A . n 
A 1 286 GLN 286 979  979 GLN GLN A . n 
A 1 287 ARG 287 980  980 ARG ARG A . n 
A 1 288 TYR 288 981  981 TYR TYR A . n 
A 1 289 LEU 289 982  982 LEU LEU A . n 
A 1 290 VAL 290 983  983 VAL VAL A . n 
A 1 291 ILE 291 984  984 ILE ILE A . n 
A 1 292 GLN 292 985  985 GLN GLN A . n 
A 1 293 GLY 293 986  986 GLY GLY A . n 
A 1 294 ASP 294 987  987 ASP ASP A . n 
A 1 295 GLU 295 988  ?   ?   ?   A . n 
A 1 296 ARG 296 989  ?   ?   ?   A . n 
A 1 297 MET 297 990  ?   ?   ?   A . n 
A 1 298 HIS 298 991  ?   ?   ?   A . n 
A 1 299 LEU 299 992  ?   ?   ?   A . n 
A 1 300 PRO 300 993  ?   ?   ?   A . n 
A 1 301 SER 301 994  ?   ?   ?   A . n 
A 1 302 PRO 302 995  ?   ?   ?   A . n 
A 1 303 THR 303 996  ?   ?   ?   A . n 
A 1 304 ASP 304 997  ?   ?   ?   A . n 
A 1 305 SER 305 998  ?   ?   ?   A . n 
A 1 306 ASN 306 999  ?   ?   ?   A . n 
A 1 307 PHE 307 1000 ?   ?   ?   A . n 
A 1 308 TYR 308 1001 ?   ?   ?   A . n 
A 1 309 ARG 309 1002 ?   ?   ?   A . n 
A 1 310 ALA 310 1003 ?   ?   ?   A . n 
A 1 311 LEU 311 1004 ?   ?   ?   A . n 
A 1 312 MET 312 1005 ?   ?   ?   A . n 
A 1 313 ASP 313 1006 ?   ?   ?   A . n 
A 1 314 GLU 314 1007 ?   ?   ?   A . n 
A 1 315 GLU 315 1008 ?   ?   ?   A . n 
A 1 316 ASP 316 1009 ?   ?   ?   A . n 
A 1 317 MET 317 1010 ?   ?   ?   A . n 
A 1 318 ASP 318 1011 ?   ?   ?   A . n 
A 1 319 ASP 319 1012 ?   ?   ?   A . n 
A 1 320 VAL 320 1013 ?   ?   ?   A . n 
A 1 321 VAL 321 1014 ?   ?   ?   A . n 
A 1 322 ASP 322 1015 ?   ?   ?   A . n 
A 1 323 ALA 323 1016 ?   ?   ?   A . n 
A 1 324 ASP 324 1017 ?   ?   ?   A . n 
A 1 325 GLU 325 1018 ?   ?   ?   A . n 
A 1 326 TYR 326 1019 ?   ?   ?   A . n 
A 1 327 LEU 327 1020 ?   ?   ?   A . n 
A 1 328 ILE 328 1021 ?   ?   ?   A . n 
A 1 329 PRO 329 1022 ?   ?   ?   A . n 
A 1 330 GLN 330 1023 ?   ?   ?   A . n 
A 1 331 GLN 331 1024 ?   ?   ?   A . n 
A 1 332 GLY 332 1025 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1H7N 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1H7N 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1H7N 1  1101 1001 A1H7N INH A . 
C 3 IOD   1  1102 1    IOD   IOD A . 
D 3 IOD   1  1103 3    IOD   IOD A . 
E 3 IOD   1  1104 7    IOD   IOD A . 
F 3 IOD   1  1105 8    IOD   IOD A . 
G 3 IOD   1  1106 9    IOD   IOD A . 
H 3 IOD   1  1107 10   IOD   IOD A . 
I 3 IOD   1  1108 12   IOD   IOD A . 
J 3 IOD   1  1109 13   IOD   IOD A . 
K 3 IOD   1  1110 14   IOD   IOD A . 
L 3 IOD   1  1111 15   IOD   IOD A . 
M 3 IOD   1  1112 16   IOD   IOD A . 
N 3 IOD   1  1113 17   IOD   IOD A . 
O 3 IOD   1  1114 18   IOD   IOD A . 
P 3 IOD   1  1115 19   IOD   IOD A . 
Q 3 IOD   1  1116 20   IOD   IOD A . 
R 4 HOH   1  1201 10   HOH   HOH A . 
R 4 HOH   2  1202 43   HOH   HOH A . 
R 4 HOH   3  1203 23   HOH   HOH A . 
R 4 HOH   4  1204 44   HOH   HOH A . 
R 4 HOH   5  1205 4    HOH   HOH A . 
R 4 HOH   6  1206 25   HOH   HOH A . 
R 4 HOH   7  1207 14   HOH   HOH A . 
R 4 HOH   8  1208 12   HOH   HOH A . 
R 4 HOH   9  1209 20   HOH   HOH A . 
R 4 HOH   10 1210 9    HOH   HOH A . 
R 4 HOH   11 1211 32   HOH   HOH A . 
R 4 HOH   12 1212 6    HOH   HOH A . 
R 4 HOH   13 1213 39   HOH   HOH A . 
R 4 HOH   14 1214 34   HOH   HOH A . 
R 4 HOH   15 1215 37   HOH   HOH A . 
R 4 HOH   16 1216 30   HOH   HOH A . 
R 4 HOH   17 1217 2    HOH   HOH A . 
R 4 HOH   18 1218 22   HOH   HOH A . 
R 4 HOH   19 1219 21   HOH   HOH A . 
R 4 HOH   20 1220 31   HOH   HOH A . 
R 4 HOH   21 1221 36   HOH   HOH A . 
R 4 HOH   22 1222 5    HOH   HOH A . 
R 4 HOH   23 1223 42   HOH   HOH A . 
R 4 HOH   24 1224 16   HOH   HOH A . 
R 4 HOH   25 1225 26   HOH   HOH A . 
R 4 HOH   26 1226 17   HOH   HOH A . 
R 4 HOH   27 1227 13   HOH   HOH A . 
R 4 HOH   28 1228 27   HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 713 ? CG  ? A LYS 20 CG  
2  1 Y 1 A LYS 713 ? CD  ? A LYS 20 CD  
3  1 Y 1 A LYS 713 ? CE  ? A LYS 20 CE  
4  1 Y 1 A LYS 713 ? NZ  ? A LYS 20 NZ  
5  1 Y 1 A PHE 723 ? CG  ? A PHE 30 CG  
6  1 Y 1 A PHE 723 ? CD1 ? A PHE 30 CD1 
7  1 Y 1 A PHE 723 ? CD2 ? A PHE 30 CD2 
8  1 Y 1 A PHE 723 ? CE1 ? A PHE 30 CE1 
9  1 Y 1 A PHE 723 ? CE2 ? A PHE 30 CE2 
10 1 Y 1 A PHE 723 ? CZ  ? A PHE 30 CZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? BUSTER  ? ? ? '2.11.8 (26-JUL-2023)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? MOSFLM  ? ? ? .                      2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                      3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                      4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9EWS 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     91.561 
_cell.length_a_esd                 ? 
_cell.length_b                     105.019 
_cell.length_b_esd                 ? 
_cell.length_c                     84.254 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9EWS 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9EWS 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.68 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.12 
_exptl_crystal.description                  'very thin plates' 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '17 % PEG8000, 0.2 M NH4I, 0.1 M PCTP pH 7.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-07-20 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97625 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I04' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97625 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I04 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9EWS 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.435 
_reflns.d_resolution_low                               53.39 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     5401 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           85.1 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                9.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.435 
_reflns_shell.d_res_low                                     2.857 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             271 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.471 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -13.25180 
_refine.aniso_B[1][2]                            0.00000 
_refine.aniso_B[1][3]                            0.00000 
_refine.aniso_B[2][2]                            7.43430 
_refine.aniso_B[2][3]                            0.00000 
_refine.aniso_B[3][3]                            5.81760 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               38.68 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.857 
_refine.correlation_coeff_Fo_to_Fc_free          0.736 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9EWS 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.435 
_refine.ls_d_res_low                             53.39 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     5358 
_refine.ls_number_reflns_R_free                  280 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    34.4 
_refine.ls_percent_reflns_R_free                 5.230 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2303 
_refine.ls_R_factor_R_free                       0.3255 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2251 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          0.000 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          0.717 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_analyze.entry_id                        9EWS 
_refine_analyze.pdbx_refine_id                  'X-RAY DIFFRACTION' 
_refine_analyze.Luzzati_coordinate_error_free   ? 
_refine_analyze.Luzzati_coordinate_error_obs    0.53 
_refine_analyze.Luzzati_d_res_low_free          ? 
_refine_analyze.Luzzati_d_res_low_obs           ? 
_refine_analyze.Luzzati_sigma_a_free            ? 
_refine_analyze.Luzzati_sigma_a_free_details    ? 
_refine_analyze.Luzzati_sigma_a_obs             ? 
_refine_analyze.Luzzati_sigma_a_obs_details     ? 
_refine_analyze.number_disordered_residues      ? 
_refine_analyze.occupancy_sum_hydrogen          ? 
_refine_analyze.occupancy_sum_non_hydrogen      ? 
_refine_analyze.RG_d_res_high                   ? 
_refine_analyze.RG_d_res_low                    ? 
_refine_analyze.RG_free                         ? 
_refine_analyze.RG_work                         ? 
_refine_analyze.RG_free_work_ratio              ? 
_refine_analyze.pdbx_Luzzati_d_res_high_obs     ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.435 
_refine_hist.d_res_low                        53.39 
_refine_hist.number_atoms_solvent             28 
_refine_hist.number_atoms_total               2253 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2178 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         47 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.007 ? 2262 ? t_bond_d                  2.00  HARMONIC     
'X-RAY DIFFRACTION' ? 0.93  ? 3064 ? t_angle_deg               2.00  HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 800  ? t_dihedral_angle_d        2.00  SINUSOIDAL   
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_incorr_chiral_ct        ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_pseud_angle             ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_trig_c_planes           ?     ?            
'X-RAY DIFFRACTION' ? ?     ? 398  ? t_gen_planes              5.00  HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 2262 ? t_it                      10.00 HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_nbd                     ?     ?            
'X-RAY DIFFRACTION' ? 2.67  ? ?    ? t_omega_torsion           ?     ?            
'X-RAY DIFFRACTION' ? 21.59 ? ?    ? t_other_torsion           ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_improper_torsion        ?     ?            
'X-RAY DIFFRACTION' ? ?     ? 292  ? t_chiral_improper_torsion 5.00  SEMIHARMONIC 
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_sum_occupancies         ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_utility_distance        ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_utility_angle           ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_utility_torsion         ?     ?            
'X-RAY DIFFRACTION' ? ?     ? 1872 ? t_ideal_dist_contact      4.00  SEMIHARMONIC 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.44 
_refine_ls_shell.d_res_low                        2.94 
_refine_ls_shell.number_reflns_all                383 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             ? 
_refine_ls_shell.number_reflns_R_work             365 
_refine_ls_shell.percent_reflns_obs               5.75 
_refine_ls_shell.percent_reflns_R_free            4.70 
_refine_ls_shell.R_factor_all                     0.2207 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.2139 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   15 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.3633 
# 
_struct.entry_id                     9EWS 
_struct.title                        
;Optimisation of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9EWS 
_struct_keywords.text            'EGFR, exon20 insertion, NPG, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 3 ? 
I N N 3 ? 
J N N 3 ? 
K N N 3 ? 
L N N 3 ? 
M N N 3 ? 
N N N 3 ? 
O N N 3 ? 
P N N 3 ? 
Q N N 3 ? 
R N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    EGFR_HUMAN 
_struct_ref.pdbx_db_accession          P00533 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHV
CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKIT
DFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLP
QPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD
EYLIPQQG
;
_struct_ref.pdbx_align_begin           695 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9EWS 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 2 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 332 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P00533 
_struct_ref_seq.db_align_beg                  695 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  1022 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       695 
_struct_ref_seq.pdbx_auth_seq_align_end       1025 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9EWS GLY A 1   ? UNP P00533 ?   ?   'expression tag'      694 1 
1 9EWS GLY A 80  ? UNP P00533 ?   ?   insertion             773 2 
1 9EWS ASN A 81  ? UNP P00533 ?   ?   insertion             774 3 
1 9EWS PRO A 82  ? UNP P00533 ?   ?   insertion             775 4 
1 9EWS ARG A 258 ? UNP P00533 VAL 948 'engineered mutation' 951 5 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2260  ? 
1 MORE         -5    ? 
1 'SSA (A^2)'  12720 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 62  ? TYR A 71  ? ALA A 755 TYR A 764 1 ? 10 
HELX_P HELX_P2  AA2 TYR A 71  ? VAL A 76  ? TYR A 764 VAL A 769 1 ? 6  
HELX_P HELX_P3  AA3 CYS A 107 ? LYS A 116 ? CYS A 800 LYS A 809 1 ? 10 
HELX_P HELX_P4  AA4 GLY A 120 ? ARG A 141 ? GLY A 813 ARG A 834 1 ? 22 
HELX_P HELX_P5  AA5 GLY A 167 ? LEU A 172 ? GLY A 860 LEU A 865 1 ? 6  
HELX_P HELX_P6  AA6 PRO A 187 ? MET A 191 ? PRO A 880 MET A 884 5 ? 5  
HELX_P HELX_P7  AA7 ALA A 192 ? ARG A 199 ? ALA A 885 ARG A 892 1 ? 8  
HELX_P HELX_P8  AA8 THR A 202 ? THR A 219 ? THR A 895 THR A 912 1 ? 18 
HELX_P HELX_P9  AA9 PRO A 229 ? LYS A 239 ? PRO A 922 LYS A 932 1 ? 11 
HELX_P HELX_P10 AB1 THR A 250 ? TRP A 261 ? THR A 943 TRP A 954 1 ? 12 
HELX_P HELX_P11 AB2 ASP A 264 ? ARG A 268 ? ASP A 957 ARG A 961 5 ? 5  
HELX_P HELX_P12 AB3 LYS A 270 ? ASP A 284 ? LYS A 963 ASP A 977 1 ? 15 
HELX_P HELX_P13 AB4 ASP A 284 ? LEU A 289 ? ASP A 977 LEU A 982 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        none 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            107 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           A1H7N 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             800 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            A1H7N 
_struct_conn.ptnr2_auth_seq_id             1101 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.712 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      A1H7N 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      107 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       A1H7N 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        1101 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       800 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        A1H7N 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          ASN 
_struct_mon_prot_cis.label_seq_id           78 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           ASN 
_struct_mon_prot_cis.auth_seq_id            771 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    79 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     772 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.03 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 12  ? ILE A 13  ? ARG A 705 ILE A 706 
AA1 2 GLY A 89  ? LEU A 92  ? GLY A 782 LEU A 785 
AA1 3 VAL A 96  ? GLN A 101 ? VAL A 789 GLN A 794 
AA1 4 ILE A 47  ? LEU A 54  ? ILE A 740 LEU A 747 
AA1 5 GLY A 31  ? TRP A 38  ? GLY A 724 TRP A 731 
AA1 6 PHE A 19  ? GLY A 28  ? PHE A 712 GLY A 721 
AA2 1 VAL A 153 ? THR A 157 ? VAL A 846 THR A 850 
AA2 2 HIS A 160 ? ILE A 163 ? HIS A 853 ILE A 856 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ARG A 12  ? N ARG A 705 O ILE A 90  ? O ILE A 783 
AA1 2 3 N CYS A 91  ? N CYS A 784 O GLN A 97  ? O GLN A 790 
AA1 3 4 O THR A 100 ? O THR A 793 N ALA A 50  ? N ALA A 743 
AA1 4 5 O ILE A 51  ? O ILE A 744 N TYR A 34  ? N TYR A 727 
AA1 5 6 O LYS A 35  ? O LYS A 728 N LYS A 23  ? N LYS A 716 
AA2 1 2 N LYS A 156 ? N LYS A 849 O HIS A 160 ? O HIS A 853 
# 
_pdbx_entry_details.entry_id                   9EWS 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 GLU A 734 ? ? -56.22  -76.33  
2  1 LYS A 739 ? ? -114.73 78.92   
3  1 ARG A 748 ? ? -49.51  150.04  
4  1 PRO A 753 ? ? -80.42  36.49   
5  1 THR A 786 ? ? -117.72 -136.40 
6  1 LYS A 809 ? ? -14.10  -58.96  
7  1 ARG A 839 ? ? 72.45   -9.66   
8  1 ASP A 840 ? ? -152.97 79.28   
9  1 LYS A 882 ? ? -64.50  7.66    
10 1 ILE A 926 ? ? -28.84  -50.37  
11 1 PRO A 940 ? ? -66.03  1.51    
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       1228 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   7.49 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 694  ? A GLY 1   
2  1 Y 1 A SER 695  ? A SER 2   
3  1 Y 1 A GLY 696  ? A GLY 3   
4  1 Y 1 A GLU 697  ? A GLU 4   
5  1 Y 1 A ALA 698  ? A ALA 5   
6  1 Y 1 A PRO 699  ? A PRO 6   
7  1 Y 1 A ASN 700  ? A ASN 7   
8  1 Y 1 A GLN 701  ? A GLN 8   
9  1 Y 1 A ALA 702  ? A ALA 9   
10 1 Y 1 A ALA 867  ? A ALA 174 
11 1 Y 1 A GLU 868  ? A GLU 175 
12 1 Y 1 A GLU 869  ? A GLU 176 
13 1 Y 1 A LYS 870  ? A LYS 177 
14 1 Y 1 A GLU 871  ? A GLU 178 
15 1 Y 1 A TYR 872  ? A TYR 179 
16 1 Y 1 A HIS 873  ? A HIS 180 
17 1 Y 1 A ALA 874  ? A ALA 181 
18 1 Y 1 A GLU 875  ? A GLU 182 
19 1 Y 1 A GLY 876  ? A GLY 183 
20 1 Y 1 A GLY 877  ? A GLY 184 
21 1 Y 1 A LYS 878  ? A LYS 185 
22 1 Y 1 A GLU 988  ? A GLU 295 
23 1 Y 1 A ARG 989  ? A ARG 296 
24 1 Y 1 A MET 990  ? A MET 297 
25 1 Y 1 A HIS 991  ? A HIS 298 
26 1 Y 1 A LEU 992  ? A LEU 299 
27 1 Y 1 A PRO 993  ? A PRO 300 
28 1 Y 1 A SER 994  ? A SER 301 
29 1 Y 1 A PRO 995  ? A PRO 302 
30 1 Y 1 A THR 996  ? A THR 303 
31 1 Y 1 A ASP 997  ? A ASP 304 
32 1 Y 1 A SER 998  ? A SER 305 
33 1 Y 1 A ASN 999  ? A ASN 306 
34 1 Y 1 A PHE 1000 ? A PHE 307 
35 1 Y 1 A TYR 1001 ? A TYR 308 
36 1 Y 1 A ARG 1002 ? A ARG 309 
37 1 Y 1 A ALA 1003 ? A ALA 310 
38 1 Y 1 A LEU 1004 ? A LEU 311 
39 1 Y 1 A MET 1005 ? A MET 312 
40 1 Y 1 A ASP 1006 ? A ASP 313 
41 1 Y 1 A GLU 1007 ? A GLU 314 
42 1 Y 1 A GLU 1008 ? A GLU 315 
43 1 Y 1 A ASP 1009 ? A ASP 316 
44 1 Y 1 A MET 1010 ? A MET 317 
45 1 Y 1 A ASP 1011 ? A ASP 318 
46 1 Y 1 A ASP 1012 ? A ASP 319 
47 1 Y 1 A VAL 1013 ? A VAL 320 
48 1 Y 1 A VAL 1014 ? A VAL 321 
49 1 Y 1 A ASP 1015 ? A ASP 322 
50 1 Y 1 A ALA 1016 ? A ALA 323 
51 1 Y 1 A ASP 1017 ? A ASP 324 
52 1 Y 1 A GLU 1018 ? A GLU 325 
53 1 Y 1 A TYR 1019 ? A TYR 326 
54 1 Y 1 A LEU 1020 ? A LEU 327 
55 1 Y 1 A ILE 1021 ? A ILE 328 
56 1 Y 1 A PRO 1022 ? A PRO 329 
57 1 Y 1 A GLN 1023 ? A GLN 330 
58 1 Y 1 A GLN 1024 ? A GLN 331 
59 1 Y 1 A GLY 1025 ? A GLY 332 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1H7N C1   C N N 1   
A1H7N C2   C N N 2   
A1H7N C3   C N N 3   
A1H7N C7   C Y N 4   
A1H7N C8   C Y N 5   
A1H7N C9   C Y N 6   
A1H7N C10  C Y N 7   
A1H7N C11  C Y N 8   
A1H7N C12  C N N 9   
A1H7N C13  C N N 10  
A1H7N C14  C Y N 11  
A1H7N C15  C Y N 12  
A1H7N C16  C Y N 13  
A1H7N C19  C N N 14  
A1H7N C20  C Y N 15  
A1H7N C21  C Y N 16  
A1H7N C22  C Y N 17  
A1H7N C24  C Y N 18  
A1H7N O    O N N 19  
A1H7N C    C N N 20  
A1H7N N    N N N 21  
A1H7N C18  C Y N 22  
A1H7N C4   C Y N 23  
A1H7N N4   N Y N 24  
A1H7N C23  C Y N 25  
A1H7N N5   N Y N 26  
A1H7N C5   C Y N 27  
A1H7N N1   N Y N 28  
A1H7N C6   C Y N 29  
A1H7N N3   N Y N 30  
A1H7N C17  C Y N 31  
A1H7N N2   N Y N 32  
A1H7N H1   H N N 33  
A1H7N H2   H N N 34  
A1H7N H3   H N N 35  
A1H7N H4   H N N 36  
A1H7N H5   H N N 37  
A1H7N H6   H N N 38  
A1H7N H7   H N N 39  
A1H7N H8   H N N 40  
A1H7N H9   H N N 41  
A1H7N H10  H N N 42  
A1H7N H11  H N N 43  
A1H7N H12  H N N 44  
A1H7N H13  H N N 45  
A1H7N H14  H N N 46  
A1H7N H15  H N N 47  
A1H7N H16  H N N 48  
A1H7N H17  H N N 49  
A1H7N H18  H N N 50  
A1H7N H19  H N N 51  
A1H7N H20  H N N 52  
ALA   N    N N N 53  
ALA   CA   C N S 54  
ALA   C    C N N 55  
ALA   O    O N N 56  
ALA   CB   C N N 57  
ALA   OXT  O N N 58  
ALA   H    H N N 59  
ALA   H2   H N N 60  
ALA   HA   H N N 61  
ALA   HB1  H N N 62  
ALA   HB2  H N N 63  
ALA   HB3  H N N 64  
ALA   HXT  H N N 65  
ARG   N    N N N 66  
ARG   CA   C N S 67  
ARG   C    C N N 68  
ARG   O    O N N 69  
ARG   CB   C N N 70  
ARG   CG   C N N 71  
ARG   CD   C N N 72  
ARG   NE   N N N 73  
ARG   CZ   C N N 74  
ARG   NH1  N N N 75  
ARG   NH2  N N N 76  
ARG   OXT  O N N 77  
ARG   H    H N N 78  
ARG   H2   H N N 79  
ARG   HA   H N N 80  
ARG   HB2  H N N 81  
ARG   HB3  H N N 82  
ARG   HG2  H N N 83  
ARG   HG3  H N N 84  
ARG   HD2  H N N 85  
ARG   HD3  H N N 86  
ARG   HE   H N N 87  
ARG   HH11 H N N 88  
ARG   HH12 H N N 89  
ARG   HH21 H N N 90  
ARG   HH22 H N N 91  
ARG   HXT  H N N 92  
ASN   N    N N N 93  
ASN   CA   C N S 94  
ASN   C    C N N 95  
ASN   O    O N N 96  
ASN   CB   C N N 97  
ASN   CG   C N N 98  
ASN   OD1  O N N 99  
ASN   ND2  N N N 100 
ASN   OXT  O N N 101 
ASN   H    H N N 102 
ASN   H2   H N N 103 
ASN   HA   H N N 104 
ASN   HB2  H N N 105 
ASN   HB3  H N N 106 
ASN   HD21 H N N 107 
ASN   HD22 H N N 108 
ASN   HXT  H N N 109 
ASP   N    N N N 110 
ASP   CA   C N S 111 
ASP   C    C N N 112 
ASP   O    O N N 113 
ASP   CB   C N N 114 
ASP   CG   C N N 115 
ASP   OD1  O N N 116 
ASP   OD2  O N N 117 
ASP   OXT  O N N 118 
ASP   H    H N N 119 
ASP   H2   H N N 120 
ASP   HA   H N N 121 
ASP   HB2  H N N 122 
ASP   HB3  H N N 123 
ASP   HD2  H N N 124 
ASP   HXT  H N N 125 
CYS   N    N N N 126 
CYS   CA   C N R 127 
CYS   C    C N N 128 
CYS   O    O N N 129 
CYS   CB   C N N 130 
CYS   SG   S N N 131 
CYS   OXT  O N N 132 
CYS   H    H N N 133 
CYS   H2   H N N 134 
CYS   HA   H N N 135 
CYS   HB2  H N N 136 
CYS   HB3  H N N 137 
CYS   HG   H N N 138 
CYS   HXT  H N N 139 
GLN   N    N N N 140 
GLN   CA   C N S 141 
GLN   C    C N N 142 
GLN   O    O N N 143 
GLN   CB   C N N 144 
GLN   CG   C N N 145 
GLN   CD   C N N 146 
GLN   OE1  O N N 147 
GLN   NE2  N N N 148 
GLN   OXT  O N N 149 
GLN   H    H N N 150 
GLN   H2   H N N 151 
GLN   HA   H N N 152 
GLN   HB2  H N N 153 
GLN   HB3  H N N 154 
GLN   HG2  H N N 155 
GLN   HG3  H N N 156 
GLN   HE21 H N N 157 
GLN   HE22 H N N 158 
GLN   HXT  H N N 159 
GLU   N    N N N 160 
GLU   CA   C N S 161 
GLU   C    C N N 162 
GLU   O    O N N 163 
GLU   CB   C N N 164 
GLU   CG   C N N 165 
GLU   CD   C N N 166 
GLU   OE1  O N N 167 
GLU   OE2  O N N 168 
GLU   OXT  O N N 169 
GLU   H    H N N 170 
GLU   H2   H N N 171 
GLU   HA   H N N 172 
GLU   HB2  H N N 173 
GLU   HB3  H N N 174 
GLU   HG2  H N N 175 
GLU   HG3  H N N 176 
GLU   HE2  H N N 177 
GLU   HXT  H N N 178 
GLY   N    N N N 179 
GLY   CA   C N N 180 
GLY   C    C N N 181 
GLY   O    O N N 182 
GLY   OXT  O N N 183 
GLY   H    H N N 184 
GLY   H2   H N N 185 
GLY   HA2  H N N 186 
GLY   HA3  H N N 187 
GLY   HXT  H N N 188 
HIS   N    N N N 189 
HIS   CA   C N S 190 
HIS   C    C N N 191 
HIS   O    O N N 192 
HIS   CB   C N N 193 
HIS   CG   C Y N 194 
HIS   ND1  N Y N 195 
HIS   CD2  C Y N 196 
HIS   CE1  C Y N 197 
HIS   NE2  N Y N 198 
HIS   OXT  O N N 199 
HIS   H    H N N 200 
HIS   H2   H N N 201 
HIS   HA   H N N 202 
HIS   HB2  H N N 203 
HIS   HB3  H N N 204 
HIS   HD1  H N N 205 
HIS   HD2  H N N 206 
HIS   HE1  H N N 207 
HIS   HE2  H N N 208 
HIS   HXT  H N N 209 
HOH   O    O N N 210 
HOH   H1   H N N 211 
HOH   H2   H N N 212 
ILE   N    N N N 213 
ILE   CA   C N S 214 
ILE   C    C N N 215 
ILE   O    O N N 216 
ILE   CB   C N S 217 
ILE   CG1  C N N 218 
ILE   CG2  C N N 219 
ILE   CD1  C N N 220 
ILE   OXT  O N N 221 
ILE   H    H N N 222 
ILE   H2   H N N 223 
ILE   HA   H N N 224 
ILE   HB   H N N 225 
ILE   HG12 H N N 226 
ILE   HG13 H N N 227 
ILE   HG21 H N N 228 
ILE   HG22 H N N 229 
ILE   HG23 H N N 230 
ILE   HD11 H N N 231 
ILE   HD12 H N N 232 
ILE   HD13 H N N 233 
ILE   HXT  H N N 234 
IOD   I    I N N 235 
LEU   N    N N N 236 
LEU   CA   C N S 237 
LEU   C    C N N 238 
LEU   O    O N N 239 
LEU   CB   C N N 240 
LEU   CG   C N N 241 
LEU   CD1  C N N 242 
LEU   CD2  C N N 243 
LEU   OXT  O N N 244 
LEU   H    H N N 245 
LEU   H2   H N N 246 
LEU   HA   H N N 247 
LEU   HB2  H N N 248 
LEU   HB3  H N N 249 
LEU   HG   H N N 250 
LEU   HD11 H N N 251 
LEU   HD12 H N N 252 
LEU   HD13 H N N 253 
LEU   HD21 H N N 254 
LEU   HD22 H N N 255 
LEU   HD23 H N N 256 
LEU   HXT  H N N 257 
LYS   N    N N N 258 
LYS   CA   C N S 259 
LYS   C    C N N 260 
LYS   O    O N N 261 
LYS   CB   C N N 262 
LYS   CG   C N N 263 
LYS   CD   C N N 264 
LYS   CE   C N N 265 
LYS   NZ   N N N 266 
LYS   OXT  O N N 267 
LYS   H    H N N 268 
LYS   H2   H N N 269 
LYS   HA   H N N 270 
LYS   HB2  H N N 271 
LYS   HB3  H N N 272 
LYS   HG2  H N N 273 
LYS   HG3  H N N 274 
LYS   HD2  H N N 275 
LYS   HD3  H N N 276 
LYS   HE2  H N N 277 
LYS   HE3  H N N 278 
LYS   HZ1  H N N 279 
LYS   HZ2  H N N 280 
LYS   HZ3  H N N 281 
LYS   HXT  H N N 282 
MET   N    N N N 283 
MET   CA   C N S 284 
MET   C    C N N 285 
MET   O    O N N 286 
MET   CB   C N N 287 
MET   CG   C N N 288 
MET   SD   S N N 289 
MET   CE   C N N 290 
MET   OXT  O N N 291 
MET   H    H N N 292 
MET   H2   H N N 293 
MET   HA   H N N 294 
MET   HB2  H N N 295 
MET   HB3  H N N 296 
MET   HG2  H N N 297 
MET   HG3  H N N 298 
MET   HE1  H N N 299 
MET   HE2  H N N 300 
MET   HE3  H N N 301 
MET   HXT  H N N 302 
PHE   N    N N N 303 
PHE   CA   C N S 304 
PHE   C    C N N 305 
PHE   O    O N N 306 
PHE   CB   C N N 307 
PHE   CG   C Y N 308 
PHE   CD1  C Y N 309 
PHE   CD2  C Y N 310 
PHE   CE1  C Y N 311 
PHE   CE2  C Y N 312 
PHE   CZ   C Y N 313 
PHE   OXT  O N N 314 
PHE   H    H N N 315 
PHE   H2   H N N 316 
PHE   HA   H N N 317 
PHE   HB2  H N N 318 
PHE   HB3  H N N 319 
PHE   HD1  H N N 320 
PHE   HD2  H N N 321 
PHE   HE1  H N N 322 
PHE   HE2  H N N 323 
PHE   HZ   H N N 324 
PHE   HXT  H N N 325 
PRO   N    N N N 326 
PRO   CA   C N S 327 
PRO   C    C N N 328 
PRO   O    O N N 329 
PRO   CB   C N N 330 
PRO   CG   C N N 331 
PRO   CD   C N N 332 
PRO   OXT  O N N 333 
PRO   H    H N N 334 
PRO   HA   H N N 335 
PRO   HB2  H N N 336 
PRO   HB3  H N N 337 
PRO   HG2  H N N 338 
PRO   HG3  H N N 339 
PRO   HD2  H N N 340 
PRO   HD3  H N N 341 
PRO   HXT  H N N 342 
SER   N    N N N 343 
SER   CA   C N S 344 
SER   C    C N N 345 
SER   O    O N N 346 
SER   CB   C N N 347 
SER   OG   O N N 348 
SER   OXT  O N N 349 
SER   H    H N N 350 
SER   H2   H N N 351 
SER   HA   H N N 352 
SER   HB2  H N N 353 
SER   HB3  H N N 354 
SER   HG   H N N 355 
SER   HXT  H N N 356 
THR   N    N N N 357 
THR   CA   C N S 358 
THR   C    C N N 359 
THR   O    O N N 360 
THR   CB   C N R 361 
THR   OG1  O N N 362 
THR   CG2  C N N 363 
THR   OXT  O N N 364 
THR   H    H N N 365 
THR   H2   H N N 366 
THR   HA   H N N 367 
THR   HB   H N N 368 
THR   HG1  H N N 369 
THR   HG21 H N N 370 
THR   HG22 H N N 371 
THR   HG23 H N N 372 
THR   HXT  H N N 373 
TRP   N    N N N 374 
TRP   CA   C N S 375 
TRP   C    C N N 376 
TRP   O    O N N 377 
TRP   CB   C N N 378 
TRP   CG   C Y N 379 
TRP   CD1  C Y N 380 
TRP   CD2  C Y N 381 
TRP   NE1  N Y N 382 
TRP   CE2  C Y N 383 
TRP   CE3  C Y N 384 
TRP   CZ2  C Y N 385 
TRP   CZ3  C Y N 386 
TRP   CH2  C Y N 387 
TRP   OXT  O N N 388 
TRP   H    H N N 389 
TRP   H2   H N N 390 
TRP   HA   H N N 391 
TRP   HB2  H N N 392 
TRP   HB3  H N N 393 
TRP   HD1  H N N 394 
TRP   HE1  H N N 395 
TRP   HE3  H N N 396 
TRP   HZ2  H N N 397 
TRP   HZ3  H N N 398 
TRP   HH2  H N N 399 
TRP   HXT  H N N 400 
TYR   N    N N N 401 
TYR   CA   C N S 402 
TYR   C    C N N 403 
TYR   O    O N N 404 
TYR   CB   C N N 405 
TYR   CG   C Y N 406 
TYR   CD1  C Y N 407 
TYR   CD2  C Y N 408 
TYR   CE1  C Y N 409 
TYR   CE2  C Y N 410 
TYR   CZ   C Y N 411 
TYR   OH   O N N 412 
TYR   OXT  O N N 413 
TYR   H    H N N 414 
TYR   H2   H N N 415 
TYR   HA   H N N 416 
TYR   HB2  H N N 417 
TYR   HB3  H N N 418 
TYR   HD1  H N N 419 
TYR   HD2  H N N 420 
TYR   HE1  H N N 421 
TYR   HE2  H N N 422 
TYR   HH   H N N 423 
TYR   HXT  H N N 424 
VAL   N    N N N 425 
VAL   CA   C N S 426 
VAL   C    C N N 427 
VAL   O    O N N 428 
VAL   CB   C N N 429 
VAL   CG1  C N N 430 
VAL   CG2  C N N 431 
VAL   OXT  O N N 432 
VAL   H    H N N 433 
VAL   H2   H N N 434 
VAL   HA   H N N 435 
VAL   HB   H N N 436 
VAL   HG11 H N N 437 
VAL   HG12 H N N 438 
VAL   HG13 H N N 439 
VAL   HG21 H N N 440 
VAL   HG22 H N N 441 
VAL   HG23 H N N 442 
VAL   HXT  H N N 443 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1H7N C8  C9   doub Y N 1   
A1H7N C8  C7   sing Y N 2   
A1H7N C9  C10  sing Y N 3   
A1H7N C7  C6   doub Y N 4   
A1H7N C10 C12  sing N N 5   
A1H7N C10 C11  doub Y N 6   
A1H7N C12 C13  trip N N 7   
A1H7N C6  C11  sing Y N 8   
A1H7N C6  C5   sing N N 9   
A1H7N C13 C14  sing N N 10  
A1H7N N3  C14  doub Y N 11  
A1H7N N3  C17  sing Y N 12  
A1H7N C14 N2   sing Y N 13  
A1H7N C17 C16  doub Y N 14  
A1H7N C23 N5   doub Y N 15  
A1H7N C23 C24  sing Y N 16  
A1H7N N5  C22  sing Y N 17  
A1H7N C24 C20  doub Y N 18  
A1H7N C5  N1   doub Y N 19  
A1H7N C5  N4   sing Y N 20  
A1H7N C22 C21  doub Y N 21  
A1H7N C20 C21  sing Y N 22  
A1H7N C20 N4   sing N N 23  
A1H7N N2  C15  doub Y N 24  
A1H7N N1  C4   sing Y N 25  
A1H7N C16 C15  sing Y N 26  
A1H7N N4  C18  sing Y N 27  
A1H7N C4  C18  doub Y N 28  
A1H7N C4  C3   sing N N 29  
A1H7N C18 C19  sing N N 30  
A1H7N C3  N    sing N N 31  
A1H7N C19 N    sing N N 32  
A1H7N N   C2   sing N N 33  
A1H7N C2  C1   sing N N 34  
A1H7N C2  O    doub N N 35  
A1H7N C1  C    sing N N 36  
A1H7N C1  H1   sing N N 37  
A1H7N C1  H2   sing N N 38  
A1H7N C3  H3   sing N N 39  
A1H7N C3  H4   sing N N 40  
A1H7N C7  H5   sing N N 41  
A1H7N C8  H6   sing N N 42  
A1H7N C9  H7   sing N N 43  
A1H7N C11 H8   sing N N 44  
A1H7N C15 H9   sing N N 45  
A1H7N C16 H10  sing N N 46  
A1H7N C19 H11  sing N N 47  
A1H7N C19 H12  sing N N 48  
A1H7N C21 H13  sing N N 49  
A1H7N C22 H14  sing N N 50  
A1H7N C24 H15  sing N N 51  
A1H7N C   H16  sing N N 52  
A1H7N C   H17  sing N N 53  
A1H7N C   H18  sing N N 54  
A1H7N C23 H19  sing N N 55  
A1H7N C17 H20  sing N N 56  
ALA   N   CA   sing N N 57  
ALA   N   H    sing N N 58  
ALA   N   H2   sing N N 59  
ALA   CA  C    sing N N 60  
ALA   CA  CB   sing N N 61  
ALA   CA  HA   sing N N 62  
ALA   C   O    doub N N 63  
ALA   C   OXT  sing N N 64  
ALA   CB  HB1  sing N N 65  
ALA   CB  HB2  sing N N 66  
ALA   CB  HB3  sing N N 67  
ALA   OXT HXT  sing N N 68  
ARG   N   CA   sing N N 69  
ARG   N   H    sing N N 70  
ARG   N   H2   sing N N 71  
ARG   CA  C    sing N N 72  
ARG   CA  CB   sing N N 73  
ARG   CA  HA   sing N N 74  
ARG   C   O    doub N N 75  
ARG   C   OXT  sing N N 76  
ARG   CB  CG   sing N N 77  
ARG   CB  HB2  sing N N 78  
ARG   CB  HB3  sing N N 79  
ARG   CG  CD   sing N N 80  
ARG   CG  HG2  sing N N 81  
ARG   CG  HG3  sing N N 82  
ARG   CD  NE   sing N N 83  
ARG   CD  HD2  sing N N 84  
ARG   CD  HD3  sing N N 85  
ARG   NE  CZ   sing N N 86  
ARG   NE  HE   sing N N 87  
ARG   CZ  NH1  sing N N 88  
ARG   CZ  NH2  doub N N 89  
ARG   NH1 HH11 sing N N 90  
ARG   NH1 HH12 sing N N 91  
ARG   NH2 HH21 sing N N 92  
ARG   NH2 HH22 sing N N 93  
ARG   OXT HXT  sing N N 94  
ASN   N   CA   sing N N 95  
ASN   N   H    sing N N 96  
ASN   N   H2   sing N N 97  
ASN   CA  C    sing N N 98  
ASN   CA  CB   sing N N 99  
ASN   CA  HA   sing N N 100 
ASN   C   O    doub N N 101 
ASN   C   OXT  sing N N 102 
ASN   CB  CG   sing N N 103 
ASN   CB  HB2  sing N N 104 
ASN   CB  HB3  sing N N 105 
ASN   CG  OD1  doub N N 106 
ASN   CG  ND2  sing N N 107 
ASN   ND2 HD21 sing N N 108 
ASN   ND2 HD22 sing N N 109 
ASN   OXT HXT  sing N N 110 
ASP   N   CA   sing N N 111 
ASP   N   H    sing N N 112 
ASP   N   H2   sing N N 113 
ASP   CA  C    sing N N 114 
ASP   CA  CB   sing N N 115 
ASP   CA  HA   sing N N 116 
ASP   C   O    doub N N 117 
ASP   C   OXT  sing N N 118 
ASP   CB  CG   sing N N 119 
ASP   CB  HB2  sing N N 120 
ASP   CB  HB3  sing N N 121 
ASP   CG  OD1  doub N N 122 
ASP   CG  OD2  sing N N 123 
ASP   OD2 HD2  sing N N 124 
ASP   OXT HXT  sing N N 125 
CYS   N   CA   sing N N 126 
CYS   N   H    sing N N 127 
CYS   N   H2   sing N N 128 
CYS   CA  C    sing N N 129 
CYS   CA  CB   sing N N 130 
CYS   CA  HA   sing N N 131 
CYS   C   O    doub N N 132 
CYS   C   OXT  sing N N 133 
CYS   CB  SG   sing N N 134 
CYS   CB  HB2  sing N N 135 
CYS   CB  HB3  sing N N 136 
CYS   SG  HG   sing N N 137 
CYS   OXT HXT  sing N N 138 
GLN   N   CA   sing N N 139 
GLN   N   H    sing N N 140 
GLN   N   H2   sing N N 141 
GLN   CA  C    sing N N 142 
GLN   CA  CB   sing N N 143 
GLN   CA  HA   sing N N 144 
GLN   C   O    doub N N 145 
GLN   C   OXT  sing N N 146 
GLN   CB  CG   sing N N 147 
GLN   CB  HB2  sing N N 148 
GLN   CB  HB3  sing N N 149 
GLN   CG  CD   sing N N 150 
GLN   CG  HG2  sing N N 151 
GLN   CG  HG3  sing N N 152 
GLN   CD  OE1  doub N N 153 
GLN   CD  NE2  sing N N 154 
GLN   NE2 HE21 sing N N 155 
GLN   NE2 HE22 sing N N 156 
GLN   OXT HXT  sing N N 157 
GLU   N   CA   sing N N 158 
GLU   N   H    sing N N 159 
GLU   N   H2   sing N N 160 
GLU   CA  C    sing N N 161 
GLU   CA  CB   sing N N 162 
GLU   CA  HA   sing N N 163 
GLU   C   O    doub N N 164 
GLU   C   OXT  sing N N 165 
GLU   CB  CG   sing N N 166 
GLU   CB  HB2  sing N N 167 
GLU   CB  HB3  sing N N 168 
GLU   CG  CD   sing N N 169 
GLU   CG  HG2  sing N N 170 
GLU   CG  HG3  sing N N 171 
GLU   CD  OE1  doub N N 172 
GLU   CD  OE2  sing N N 173 
GLU   OE2 HE2  sing N N 174 
GLU   OXT HXT  sing N N 175 
GLY   N   CA   sing N N 176 
GLY   N   H    sing N N 177 
GLY   N   H2   sing N N 178 
GLY   CA  C    sing N N 179 
GLY   CA  HA2  sing N N 180 
GLY   CA  HA3  sing N N 181 
GLY   C   O    doub N N 182 
GLY   C   OXT  sing N N 183 
GLY   OXT HXT  sing N N 184 
HIS   N   CA   sing N N 185 
HIS   N   H    sing N N 186 
HIS   N   H2   sing N N 187 
HIS   CA  C    sing N N 188 
HIS   CA  CB   sing N N 189 
HIS   CA  HA   sing N N 190 
HIS   C   O    doub N N 191 
HIS   C   OXT  sing N N 192 
HIS   CB  CG   sing N N 193 
HIS   CB  HB2  sing N N 194 
HIS   CB  HB3  sing N N 195 
HIS   CG  ND1  sing Y N 196 
HIS   CG  CD2  doub Y N 197 
HIS   ND1 CE1  doub Y N 198 
HIS   ND1 HD1  sing N N 199 
HIS   CD2 NE2  sing Y N 200 
HIS   CD2 HD2  sing N N 201 
HIS   CE1 NE2  sing Y N 202 
HIS   CE1 HE1  sing N N 203 
HIS   NE2 HE2  sing N N 204 
HIS   OXT HXT  sing N N 205 
HOH   O   H1   sing N N 206 
HOH   O   H2   sing N N 207 
ILE   N   CA   sing N N 208 
ILE   N   H    sing N N 209 
ILE   N   H2   sing N N 210 
ILE   CA  C    sing N N 211 
ILE   CA  CB   sing N N 212 
ILE   CA  HA   sing N N 213 
ILE   C   O    doub N N 214 
ILE   C   OXT  sing N N 215 
ILE   CB  CG1  sing N N 216 
ILE   CB  CG2  sing N N 217 
ILE   CB  HB   sing N N 218 
ILE   CG1 CD1  sing N N 219 
ILE   CG1 HG12 sing N N 220 
ILE   CG1 HG13 sing N N 221 
ILE   CG2 HG21 sing N N 222 
ILE   CG2 HG22 sing N N 223 
ILE   CG2 HG23 sing N N 224 
ILE   CD1 HD11 sing N N 225 
ILE   CD1 HD12 sing N N 226 
ILE   CD1 HD13 sing N N 227 
ILE   OXT HXT  sing N N 228 
LEU   N   CA   sing N N 229 
LEU   N   H    sing N N 230 
LEU   N   H2   sing N N 231 
LEU   CA  C    sing N N 232 
LEU   CA  CB   sing N N 233 
LEU   CA  HA   sing N N 234 
LEU   C   O    doub N N 235 
LEU   C   OXT  sing N N 236 
LEU   CB  CG   sing N N 237 
LEU   CB  HB2  sing N N 238 
LEU   CB  HB3  sing N N 239 
LEU   CG  CD1  sing N N 240 
LEU   CG  CD2  sing N N 241 
LEU   CG  HG   sing N N 242 
LEU   CD1 HD11 sing N N 243 
LEU   CD1 HD12 sing N N 244 
LEU   CD1 HD13 sing N N 245 
LEU   CD2 HD21 sing N N 246 
LEU   CD2 HD22 sing N N 247 
LEU   CD2 HD23 sing N N 248 
LEU   OXT HXT  sing N N 249 
LYS   N   CA   sing N N 250 
LYS   N   H    sing N N 251 
LYS   N   H2   sing N N 252 
LYS   CA  C    sing N N 253 
LYS   CA  CB   sing N N 254 
LYS   CA  HA   sing N N 255 
LYS   C   O    doub N N 256 
LYS   C   OXT  sing N N 257 
LYS   CB  CG   sing N N 258 
LYS   CB  HB2  sing N N 259 
LYS   CB  HB3  sing N N 260 
LYS   CG  CD   sing N N 261 
LYS   CG  HG2  sing N N 262 
LYS   CG  HG3  sing N N 263 
LYS   CD  CE   sing N N 264 
LYS   CD  HD2  sing N N 265 
LYS   CD  HD3  sing N N 266 
LYS   CE  NZ   sing N N 267 
LYS   CE  HE2  sing N N 268 
LYS   CE  HE3  sing N N 269 
LYS   NZ  HZ1  sing N N 270 
LYS   NZ  HZ2  sing N N 271 
LYS   NZ  HZ3  sing N N 272 
LYS   OXT HXT  sing N N 273 
MET   N   CA   sing N N 274 
MET   N   H    sing N N 275 
MET   N   H2   sing N N 276 
MET   CA  C    sing N N 277 
MET   CA  CB   sing N N 278 
MET   CA  HA   sing N N 279 
MET   C   O    doub N N 280 
MET   C   OXT  sing N N 281 
MET   CB  CG   sing N N 282 
MET   CB  HB2  sing N N 283 
MET   CB  HB3  sing N N 284 
MET   CG  SD   sing N N 285 
MET   CG  HG2  sing N N 286 
MET   CG  HG3  sing N N 287 
MET   SD  CE   sing N N 288 
MET   CE  HE1  sing N N 289 
MET   CE  HE2  sing N N 290 
MET   CE  HE3  sing N N 291 
MET   OXT HXT  sing N N 292 
PHE   N   CA   sing N N 293 
PHE   N   H    sing N N 294 
PHE   N   H2   sing N N 295 
PHE   CA  C    sing N N 296 
PHE   CA  CB   sing N N 297 
PHE   CA  HA   sing N N 298 
PHE   C   O    doub N N 299 
PHE   C   OXT  sing N N 300 
PHE   CB  CG   sing N N 301 
PHE   CB  HB2  sing N N 302 
PHE   CB  HB3  sing N N 303 
PHE   CG  CD1  doub Y N 304 
PHE   CG  CD2  sing Y N 305 
PHE   CD1 CE1  sing Y N 306 
PHE   CD1 HD1  sing N N 307 
PHE   CD2 CE2  doub Y N 308 
PHE   CD2 HD2  sing N N 309 
PHE   CE1 CZ   doub Y N 310 
PHE   CE1 HE1  sing N N 311 
PHE   CE2 CZ   sing Y N 312 
PHE   CE2 HE2  sing N N 313 
PHE   CZ  HZ   sing N N 314 
PHE   OXT HXT  sing N N 315 
PRO   N   CA   sing N N 316 
PRO   N   CD   sing N N 317 
PRO   N   H    sing N N 318 
PRO   CA  C    sing N N 319 
PRO   CA  CB   sing N N 320 
PRO   CA  HA   sing N N 321 
PRO   C   O    doub N N 322 
PRO   C   OXT  sing N N 323 
PRO   CB  CG   sing N N 324 
PRO   CB  HB2  sing N N 325 
PRO   CB  HB3  sing N N 326 
PRO   CG  CD   sing N N 327 
PRO   CG  HG2  sing N N 328 
PRO   CG  HG3  sing N N 329 
PRO   CD  HD2  sing N N 330 
PRO   CD  HD3  sing N N 331 
PRO   OXT HXT  sing N N 332 
SER   N   CA   sing N N 333 
SER   N   H    sing N N 334 
SER   N   H2   sing N N 335 
SER   CA  C    sing N N 336 
SER   CA  CB   sing N N 337 
SER   CA  HA   sing N N 338 
SER   C   O    doub N N 339 
SER   C   OXT  sing N N 340 
SER   CB  OG   sing N N 341 
SER   CB  HB2  sing N N 342 
SER   CB  HB3  sing N N 343 
SER   OG  HG   sing N N 344 
SER   OXT HXT  sing N N 345 
THR   N   CA   sing N N 346 
THR   N   H    sing N N 347 
THR   N   H2   sing N N 348 
THR   CA  C    sing N N 349 
THR   CA  CB   sing N N 350 
THR   CA  HA   sing N N 351 
THR   C   O    doub N N 352 
THR   C   OXT  sing N N 353 
THR   CB  OG1  sing N N 354 
THR   CB  CG2  sing N N 355 
THR   CB  HB   sing N N 356 
THR   OG1 HG1  sing N N 357 
THR   CG2 HG21 sing N N 358 
THR   CG2 HG22 sing N N 359 
THR   CG2 HG23 sing N N 360 
THR   OXT HXT  sing N N 361 
TRP   N   CA   sing N N 362 
TRP   N   H    sing N N 363 
TRP   N   H2   sing N N 364 
TRP   CA  C    sing N N 365 
TRP   CA  CB   sing N N 366 
TRP   CA  HA   sing N N 367 
TRP   C   O    doub N N 368 
TRP   C   OXT  sing N N 369 
TRP   CB  CG   sing N N 370 
TRP   CB  HB2  sing N N 371 
TRP   CB  HB3  sing N N 372 
TRP   CG  CD1  doub Y N 373 
TRP   CG  CD2  sing Y N 374 
TRP   CD1 NE1  sing Y N 375 
TRP   CD1 HD1  sing N N 376 
TRP   CD2 CE2  doub Y N 377 
TRP   CD2 CE3  sing Y N 378 
TRP   NE1 CE2  sing Y N 379 
TRP   NE1 HE1  sing N N 380 
TRP   CE2 CZ2  sing Y N 381 
TRP   CE3 CZ3  doub Y N 382 
TRP   CE3 HE3  sing N N 383 
TRP   CZ2 CH2  doub Y N 384 
TRP   CZ2 HZ2  sing N N 385 
TRP   CZ3 CH2  sing Y N 386 
TRP   CZ3 HZ3  sing N N 387 
TRP   CH2 HH2  sing N N 388 
TRP   OXT HXT  sing N N 389 
TYR   N   CA   sing N N 390 
TYR   N   H    sing N N 391 
TYR   N   H2   sing N N 392 
TYR   CA  C    sing N N 393 
TYR   CA  CB   sing N N 394 
TYR   CA  HA   sing N N 395 
TYR   C   O    doub N N 396 
TYR   C   OXT  sing N N 397 
TYR   CB  CG   sing N N 398 
TYR   CB  HB2  sing N N 399 
TYR   CB  HB3  sing N N 400 
TYR   CG  CD1  doub Y N 401 
TYR   CG  CD2  sing Y N 402 
TYR   CD1 CE1  sing Y N 403 
TYR   CD1 HD1  sing N N 404 
TYR   CD2 CE2  doub Y N 405 
TYR   CD2 HD2  sing N N 406 
TYR   CE1 CZ   doub Y N 407 
TYR   CE1 HE1  sing N N 408 
TYR   CE2 CZ   sing Y N 409 
TYR   CE2 HE2  sing N N 410 
TYR   CZ  OH   sing N N 411 
TYR   OH  HH   sing N N 412 
TYR   OXT HXT  sing N N 413 
VAL   N   CA   sing N N 414 
VAL   N   H    sing N N 415 
VAL   N   H2   sing N N 416 
VAL   CA  C    sing N N 417 
VAL   CA  CB   sing N N 418 
VAL   CA  HA   sing N N 419 
VAL   C   O    doub N N 420 
VAL   C   OXT  sing N N 421 
VAL   CB  CG1  sing N N 422 
VAL   CB  CG2  sing N N 423 
VAL   CB  HB   sing N N 424 
VAL   CG1 HG11 sing N N 425 
VAL   CG1 HG12 sing N N 426 
VAL   CG1 HG13 sing N N 427 
VAL   CG2 HG21 sing N N 428 
VAL   CG2 HG22 sing N N 429 
VAL   CG2 HG23 sing N N 430 
VAL   OXT HXT  sing N N 431 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'in house' 
# 
_atom_sites.entry_id                    9EWS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010922 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009522 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011869 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
I 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LEU   A 1 10  ? -49.767 -21.932 -4.144  1.00 59.67 ? 703  LEU   A N   1 
ATOM   2    C CA  . LEU   A 1 10  ? -48.961 -21.813 -2.930  1.00 60.04 ? 703  LEU   A CA  1 
ATOM   3    C C   . LEU   A 1 10  ? -47.600 -21.170 -3.273  1.00 59.92 ? 703  LEU   A C   1 
ATOM   4    O O   . LEU   A 1 10  ? -47.153 -20.257 -2.570  1.00 60.03 ? 703  LEU   A O   1 
ATOM   5    C CB  . LEU   A 1 10  ? -48.791 -23.200 -2.285  1.00 60.49 ? 703  LEU   A CB  1 
ATOM   6    C CG  . LEU   A 1 10  ? -48.328 -23.259 -0.830  1.00 62.51 ? 703  LEU   A CG  1 
ATOM   7    C CD1 . LEU   A 1 10  ? -49.251 -22.457 0.091   1.00 63.17 ? 703  LEU   A CD1 1 
ATOM   8    C CD2 . LEU   A 1 10  ? -48.245 -24.700 -0.354  1.00 63.33 ? 703  LEU   A CD2 1 
ATOM   9    N N   . LEU   A 1 11  ? -46.968 -21.613 -4.383  1.00 59.35 ? 704  LEU   A N   1 
ATOM   10   C CA  . LEU   A 1 11  ? -45.690 -21.057 -4.844  1.00 59.18 ? 704  LEU   A CA  1 
ATOM   11   C C   . LEU   A 1 11  ? -45.866 -20.401 -6.216  1.00 58.79 ? 704  LEU   A C   1 
ATOM   12   O O   . LEU   A 1 11  ? -46.193 -21.087 -7.195  1.00 59.15 ? 704  LEU   A O   1 
ATOM   13   C CB  . LEU   A 1 11  ? -44.596 -22.142 -4.911  1.00 59.37 ? 704  LEU   A CB  1 
ATOM   14   C CG  . LEU   A 1 11  ? -43.283 -21.759 -5.608  1.00 60.76 ? 704  LEU   A CG  1 
ATOM   15   C CD1 . LEU   A 1 11  ? -42.322 -21.094 -4.646  1.00 61.20 ? 704  LEU   A CD1 1 
ATOM   16   C CD2 . LEU   A 1 11  ? -42.654 -22.957 -6.295  1.00 61.36 ? 704  LEU   A CD2 1 
ATOM   17   N N   . ARG   A 1 12  ? -45.614 -19.087 -6.297  1.00 57.71 ? 705  ARG   A N   1 
ATOM   18   C CA  . ARG   A 1 12  ? -45.753 -18.380 -7.560  1.00 57.12 ? 705  ARG   A CA  1 
ATOM   19   C C   . ARG   A 1 12  ? -44.585 -18.652 -8.508  1.00 56.08 ? 705  ARG   A C   1 
ATOM   20   O O   . ARG   A 1 12  ? -43.439 -18.403 -8.144  1.00 55.91 ? 705  ARG   A O   1 
ATOM   21   C CB  . ARG   A 1 12  ? -45.901 -16.872 -7.321  1.00 58.64 ? 705  ARG   A CB  1 
ATOM   22   C CG  . ARG   A 1 12  ? -47.172 -16.472 -6.574  1.00 62.09 ? 705  ARG   A CG  1 
ATOM   23   C CD  . ARG   A 1 12  ? -47.439 -14.977 -6.727  1.00 65.28 ? 705  ARG   A CD  1 
ATOM   24   N NE  . ARG   A 1 12  ? -48.392 -14.453 -5.742  1.00 67.82 ? 705  ARG   A NE  1 
ATOM   25   C CZ  . ARG   A 1 12  ? -48.056 -14.016 -4.530  1.00 69.51 ? 705  ARG   A CZ  1 
ATOM   26   N NH1 . ARG   A 1 12  ? -48.986 -13.551 -3.705  1.00 69.02 ? 705  ARG   A NH1 1 
ATOM   27   N NH2 . ARG   A 1 12  ? -46.789 -14.042 -4.133  1.00 69.06 ? 705  ARG   A NH2 1 
ATOM   28   N N   . ILE   A 1 13  ? -44.868 -19.174 -9.721  1.00 55.17 ? 706  ILE   A N   1 
ATOM   29   C CA  . ILE   A 1 13  ? -43.817 -19.385 -10.729 1.00 54.58 ? 706  ILE   A CA  1 
ATOM   30   C C   . ILE   A 1 13  ? -43.736 -18.087 -11.495 1.00 53.82 ? 706  ILE   A C   1 
ATOM   31   O O   . ILE   A 1 13  ? -44.766 -17.562 -11.928 1.00 53.91 ? 706  ILE   A O   1 
ATOM   32   C CB  . ILE   A 1 13  ? -44.023 -20.591 -11.675 1.00 54.92 ? 706  ILE   A CB  1 
ATOM   33   C CG1 . ILE   A 1 13  ? -44.704 -21.783 -10.971 1.00 56.09 ? 706  ILE   A CG1 1 
ATOM   34   C CG2 . ILE   A 1 13  ? -42.690 -20.989 -12.311 1.00 55.18 ? 706  ILE   A CG2 1 
ATOM   35   C CD1 . ILE   A 1 13  ? -43.928 -22.388 -9.789  1.00 57.47 ? 706  ILE   A CD1 1 
ATOM   36   N N   . LEU   A 1 14  ? -42.535 -17.531 -11.616 1.00 53.10 ? 707  LEU   A N   1 
ATOM   37   C CA  . LEU   A 1 14  ? -42.381 -16.206 -12.199 1.00 53.12 ? 707  LEU   A CA  1 
ATOM   38   C C   . LEU   A 1 14  ? -41.742 -16.151 -13.606 1.00 52.95 ? 707  LEU   A C   1 
ATOM   39   O O   . LEU   A 1 14  ? -40.620 -16.619 -13.824 1.00 53.18 ? 707  LEU   A O   1 
ATOM   40   C CB  . LEU   A 1 14  ? -41.616 -15.305 -11.212 1.00 53.11 ? 707  LEU   A CB  1 
ATOM   41   C CG  . LEU   A 1 14  ? -42.485 -14.383 -10.340 1.00 54.24 ? 707  LEU   A CG  1 
ATOM   42   C CD1 . LEU   A 1 14  ? -43.480 -15.153 -9.513  1.00 54.72 ? 707  LEU   A CD1 1 
ATOM   43   C CD2 . LEU   A 1 14  ? -41.646 -13.557 -9.421  1.00 54.81 ? 707  LEU   A CD2 1 
ATOM   44   N N   . LYS   A 1 15  ? -42.477 -15.545 -14.555 1.00 52.28 ? 708  LYS   A N   1 
ATOM   45   C CA  . LYS   A 1 15  ? -41.998 -15.325 -15.921 1.00 52.13 ? 708  LYS   A CA  1 
ATOM   46   C C   . LYS   A 1 15  ? -40.920 -14.242 -15.876 1.00 51.24 ? 708  LYS   A C   1 
ATOM   47   O O   . LYS   A 1 15  ? -40.942 -13.383 -14.985 1.00 51.38 ? 708  LYS   A O   1 
ATOM   48   C CB  . LYS   A 1 15  ? -43.145 -14.867 -16.842 1.00 54.20 ? 708  LYS   A CB  1 
ATOM   49   C CG  . LYS   A 1 15  ? -44.256 -15.895 -16.998 1.00 58.76 ? 708  LYS   A CG  1 
ATOM   50   C CD  . LYS   A 1 15  ? -45.614 -15.237 -17.218 1.00 63.32 ? 708  LYS   A CD  1 
ATOM   51   C CE  . LYS   A 1 15  ? -46.736 -16.071 -16.641 1.00 67.08 ? 708  LYS   A CE  1 
ATOM   52   N NZ  . LYS   A 1 15  ? -46.466 -16.467 -15.229 1.00 69.20 ? 708  LYS   A NZ  1 
ATOM   53   N N   . GLU   A 1 16  ? -39.980 -14.274 -16.829 1.00 49.91 ? 709  GLU   A N   1 
ATOM   54   C CA  . GLU   A 1 16  ? -38.901 -13.287 -16.854 1.00 49.22 ? 709  GLU   A CA  1 
ATOM   55   C C   . GLU   A 1 16  ? -39.388 -11.856 -17.086 1.00 48.19 ? 709  GLU   A C   1 
ATOM   56   O O   . GLU   A 1 16  ? -38.722 -10.907 -16.679 1.00 48.04 ? 709  GLU   A O   1 
ATOM   57   C CB  . GLU   A 1 16  ? -37.817 -13.682 -17.860 1.00 51.34 ? 709  GLU   A CB  1 
ATOM   58   C CG  . GLU   A 1 16  ? -37.199 -15.033 -17.557 1.00 55.51 ? 709  GLU   A CG  1 
ATOM   59   C CD  . GLU   A 1 16  ? -35.739 -15.132 -17.945 1.00 61.16 ? 709  GLU   A CD  1 
ATOM   60   O OE1 . GLU   A 1 16  ? -35.447 -15.729 -19.006 1.00 62.55 ? 709  GLU   A OE1 1 
ATOM   61   O OE2 . GLU   A 1 16  ? -34.886 -14.613 -17.188 1.00 62.79 ? 709  GLU   A OE2 1 
ATOM   62   N N   . THR   A 1 17  ? -40.553 -11.701 -17.718 1.00 47.49 ? 710  THR   A N   1 
ATOM   63   C CA  . THR   A 1 17  ? -41.140 -10.390 -17.978 1.00 47.28 ? 710  THR   A CA  1 
ATOM   64   C C   . THR   A 1 17  ? -41.941 -9.844  -16.793 1.00 46.82 ? 710  THR   A C   1 
ATOM   65   O O   . THR   A 1 17  ? -42.268 -8.657  -16.786 1.00 47.14 ? 710  THR   A O   1 
ATOM   66   C CB  . THR   A 1 17  ? -41.963 -10.421 -19.249 1.00 48.43 ? 710  THR   A CB  1 
ATOM   67   O OG1 . THR   A 1 17  ? -43.111 -11.243 -19.029 1.00 49.31 ? 710  THR   A OG1 1 
ATOM   68   C CG2 . THR   A 1 17  ? -41.162 -10.926 -20.434 1.00 48.97 ? 710  THR   A CG2 1 
ATOM   69   N N   . GLU   A 1 18  ? -42.261 -10.694 -15.800 1.00 45.88 ? 711  GLU   A N   1 
ATOM   70   C CA  . GLU   A 1 18  ? -42.961 -10.274 -14.590 1.00 45.38 ? 711  GLU   A CA  1 
ATOM   71   C C   . GLU   A 1 18  ? -42.027 -9.452  -13.676 1.00 44.19 ? 711  GLU   A C   1 
ATOM   72   O O   . GLU   A 1 18  ? -42.503 -8.600  -12.946 1.00 44.09 ? 711  GLU   A O   1 
ATOM   73   C CB  . GLU   A 1 18  ? -43.485 -11.494 -13.819 1.00 47.84 ? 711  GLU   A CB  1 
ATOM   74   C CG  . GLU   A 1 18  ? -44.667 -12.192 -14.464 1.00 52.85 ? 711  GLU   A CG  1 
ATOM   75   C CD  . GLU   A 1 18  ? -45.246 -13.286 -13.588 1.00 59.77 ? 711  GLU   A CD  1 
ATOM   76   O OE1 . GLU   A 1 18  ? -45.830 -12.959 -12.528 1.00 61.68 ? 711  GLU   A OE1 1 
ATOM   77   O OE2 . GLU   A 1 18  ? -45.091 -14.475 -13.950 1.00 61.32 ? 711  GLU   A OE2 1 
ATOM   78   N N   . PHE   A 1 19  ? -40.704 -9.700  -13.717 1.00 43.08 ? 712  PHE   A N   1 
ATOM   79   C CA  . PHE   A 1 19  ? -39.739 -8.989  -12.873 1.00 42.25 ? 712  PHE   A CA  1 
ATOM   80   C C   . PHE   A 1 19  ? -38.446 -8.577  -13.610 1.00 41.59 ? 712  PHE   A C   1 
ATOM   81   O O   . PHE   A 1 19  ? -38.071 -9.186  -14.614 1.00 41.84 ? 712  PHE   A O   1 
ATOM   82   C CB  . PHE   A 1 19  ? -39.395 -9.842  -11.643 1.00 41.77 ? 712  PHE   A CB  1 
ATOM   83   C CG  . PHE   A 1 19  ? -38.574 -11.066 -11.965 1.00 42.16 ? 712  PHE   A CG  1 
ATOM   84   C CD1 . PHE   A 1 19  ? -39.178 -12.228 -12.412 1.00 42.92 ? 712  PHE   A CD1 1 
ATOM   85   C CD2 . PHE   A 1 19  ? -37.199 -11.056 -11.815 1.00 42.84 ? 712  PHE   A CD2 1 
ATOM   86   C CE1 . PHE   A 1 19  ? -38.422 -13.353 -12.712 1.00 43.59 ? 712  PHE   A CE1 1 
ATOM   87   C CE2 . PHE   A 1 19  ? -36.446 -12.184 -12.109 1.00 43.55 ? 712  PHE   A CE2 1 
ATOM   88   C CZ  . PHE   A 1 19  ? -37.062 -13.324 -12.555 1.00 43.40 ? 712  PHE   A CZ  1 
ATOM   89   N N   . LYS   A 1 20  ? -37.743 -7.575  -13.081 1.00 40.55 ? 713  LYS   A N   1 
ATOM   90   C CA  . LYS   A 1 20  ? -36.485 -7.119  -13.662 1.00 40.13 ? 713  LYS   A CA  1 
ATOM   91   C C   . LYS   A 1 20  ? -35.599 -6.599  -12.539 1.00 39.42 ? 713  LYS   A C   1 
ATOM   92   O O   . LYS   A 1 20  ? -35.998 -5.679  -11.826 1.00 39.62 ? 713  LYS   A O   1 
ATOM   93   C CB  . LYS   A 1 20  ? -36.729 -6.032  -14.722 1.00 41.79 ? 713  LYS   A CB  1 
ATOM   94   N N   . LYS   A 1 21  ? -34.419 -7.212  -12.346 1.00 38.45 ? 714  LYS   A N   1 
ATOM   95   C CA  . LYS   A 1 21  ? -33.487 -6.831  -11.271 1.00 37.78 ? 714  LYS   A CA  1 
ATOM   96   C C   . LYS   A 1 21  ? -32.821 -5.480  -11.563 1.00 36.83 ? 714  LYS   A C   1 
ATOM   97   O O   . LYS   A 1 21  ? -31.791 -5.422  -12.234 1.00 36.91 ? 714  LYS   A O   1 
ATOM   98   C CB  . LYS   A 1 21  ? -32.421 -7.920  -11.016 1.00 39.09 ? 714  LYS   A CB  1 
ATOM   99   C CG  . LYS   A 1 21  ? -32.663 -9.284  -11.665 1.00 42.39 ? 714  LYS   A CG  1 
ATOM   100  C CD  . LYS   A 1 21  ? -31.350 -10.020 -11.850 1.00 46.26 ? 714  LYS   A CD  1 
ATOM   101  C CE  . LYS   A 1 21  ? -31.471 -11.236 -12.729 1.00 49.72 ? 714  LYS   A CE  1 
ATOM   102  N NZ  . LYS   A 1 21  ? -32.115 -10.924 -14.030 1.00 52.16 ? 714  LYS   A NZ  1 
ATOM   103  N N   . ILE   A 1 22  ? -33.420 -4.399  -11.062 1.00 35.72 ? 715  ILE   A N   1 
ATOM   104  C CA  . ILE   A 1 22  ? -32.958 -3.039  -11.310 1.00 35.00 ? 715  ILE   A CA  1 
ATOM   105  C C   . ILE   A 1 22  ? -31.562 -2.749  -10.705 1.00 34.28 ? 715  ILE   A C   1 
ATOM   106  O O   . ILE   A 1 22  ? -30.623 -2.582  -11.472 1.00 34.46 ? 715  ILE   A O   1 
ATOM   107  C CB  . ILE   A 1 22  ? -34.033 -2.016  -10.877 1.00 35.38 ? 715  ILE   A CB  1 
ATOM   108  C CG1 . ILE   A 1 22  ? -35.391 -2.330  -11.531 1.00 36.01 ? 715  ILE   A CG1 1 
ATOM   109  C CG2 . ILE   A 1 22  ? -33.581 -0.615  -11.208 1.00 36.01 ? 715  ILE   A CG2 1 
ATOM   110  C CD1 . ILE   A 1 22  ? -36.560 -1.720  -10.831 1.00 37.06 ? 715  ILE   A CD1 1 
ATOM   111  N N   . LYS   A 1 23  ? -31.408 -2.712  -9.366  1.00 33.30 ? 716  LYS   A N   1 
ATOM   112  C CA  . LYS   A 1 23  ? -30.115 -2.448  -8.716  1.00 32.58 ? 716  LYS   A CA  1 
ATOM   113  C C   . LYS   A 1 23  ? -29.543 -3.725  -8.030  1.00 32.18 ? 716  LYS   A C   1 
ATOM   114  O O   . LYS   A 1 23  ? -30.210 -4.752  -7.982  1.00 31.84 ? 716  LYS   A O   1 
ATOM   115  C CB  . LYS   A 1 23  ? -30.251 -1.267  -7.723  1.00 33.01 ? 716  LYS   A CB  1 
ATOM   116  C CG  . LYS   A 1 23  ? -28.947 -0.512  -7.467  1.00 34.97 ? 716  LYS   A CG  1 
ATOM   117  C CD  . LYS   A 1 23  ? -29.124 0.713   -6.574  1.00 37.45 ? 716  LYS   A CD  1 
ATOM   118  C CE  . LYS   A 1 23  ? -27.790 1.227   -6.075  1.00 39.52 ? 716  LYS   A CE  1 
ATOM   119  N NZ  . LYS   A 1 23  ? -27.815 2.688   -5.809  1.00 40.68 ? 716  LYS   A NZ  1 
ATOM   120  N N   . VAL   A 1 24  ? -28.302 -3.672  -7.537  1.00 31.99 ? 717  VAL   A N   1 
ATOM   121  C CA  . VAL   A 1 24  ? -27.676 -4.808  -6.865  1.00 32.13 ? 717  VAL   A CA  1 
ATOM   122  C C   . VAL   A 1 24  ? -27.436 -4.433  -5.419  1.00 31.96 ? 717  VAL   A C   1 
ATOM   123  O O   . VAL   A 1 24  ? -26.881 -3.373  -5.149  1.00 32.01 ? 717  VAL   A O   1 
ATOM   124  C CB  . VAL   A 1 24  ? -26.347 -5.194  -7.542  1.00 32.97 ? 717  VAL   A CB  1 
ATOM   125  C CG1 . VAL   A 1 24  ? -25.750 -6.443  -6.909  1.00 33.47 ? 717  VAL   A CG1 1 
ATOM   126  C CG2 . VAL   A 1 24  ? -26.525 -5.368  -9.045  1.00 33.61 ? 717  VAL   A CG2 1 
ATOM   127  N N   . LEU   A 1 25  ? -27.854 -5.287  -4.489  1.00 31.76 ? 718  LEU   A N   1 
ATOM   128  C CA  . LEU   A 1 25  ? -27.690 -5.059  -3.052  1.00 32.00 ? 718  LEU   A CA  1 
ATOM   129  C C   . LEU   A 1 25  ? -26.306 -5.449  -2.532  1.00 32.11 ? 718  LEU   A C   1 
ATOM   130  O O   . LEU   A 1 25  ? -25.799 -4.856  -1.583  1.00 32.22 ? 718  LEU   A O   1 
ATOM   131  C CB  . LEU   A 1 25  ? -28.740 -5.868  -2.298  1.00 32.29 ? 718  LEU   A CB  1 
ATOM   132  C CG  . LEU   A 1 25  ? -30.130 -5.279  -2.269  1.00 34.04 ? 718  LEU   A CG  1 
ATOM   133  C CD1 . LEU   A 1 25  ? -31.165 -6.370  -2.262  1.00 34.84 ? 718  LEU   A CD1 1 
ATOM   134  C CD2 . LEU   A 1 25  ? -30.310 -4.376  -1.066  1.00 34.72 ? 718  LEU   A CD2 1 
ATOM   135  N N   . GLY   A 1 26  ? -25.738 -6.475  -3.130  1.00 32.09 ? 719  GLY   A N   1 
ATOM   136  C CA  . GLY   A 1 26  ? -24.450 -7.031  -2.749  1.00 32.77 ? 719  GLY   A CA  1 
ATOM   137  C C   . GLY   A 1 26  ? -24.350 -8.461  -3.234  1.00 33.59 ? 719  GLY   A C   1 
ATOM   138  O O   . GLY   A 1 26  ? -25.373 -9.111  -3.492  1.00 33.69 ? 719  GLY   A O   1 
ATOM   139  N N   . SER   A 1 27  ? -23.127 -8.961  -3.389  1.00 34.08 ? 720  SER   A N   1 
ATOM   140  C CA  . SER   A 1 27  ? -22.937 -10.320 -3.885  1.00 34.93 ? 720  SER   A CA  1 
ATOM   141  C C   . SER   A 1 27  ? -22.857 -11.339 -2.754  1.00 35.61 ? 720  SER   A C   1 
ATOM   142  O O   . SER   A 1 27  ? -22.407 -11.024 -1.646  1.00 35.83 ? 720  SER   A O   1 
ATOM   143  C CB  . SER   A 1 27  ? -21.710 -10.400 -4.786  1.00 36.22 ? 720  SER   A CB  1 
ATOM   144  O OG  . SER   A 1 27  ? -21.622 -11.669 -5.410  1.00 38.53 ? 720  SER   A OG  1 
ATOM   145  N N   . GLY   A 1 28  ? -23.336 -12.540 -3.041  1.00 35.69 ? 721  GLY   A N   1 
ATOM   146  C CA  . GLY   A 1 28  ? -23.302 -13.661 -2.111  1.00 36.31 ? 721  GLY   A CA  1 
ATOM   147  C C   . GLY   A 1 28  ? -22.166 -14.618 -2.420  1.00 36.67 ? 721  GLY   A C   1 
ATOM   148  O O   . GLY   A 1 28  ? -21.464 -14.453 -3.426  1.00 36.98 ? 721  GLY   A O   1 
ATOM   149  N N   . ALA   A 1 29  ? -21.974 -15.637 -1.570  1.00 36.51 ? 722  ALA   A N   1 
ATOM   150  C CA  . ALA   A 1 29  ? -20.906 -16.622 -1.767  1.00 36.97 ? 722  ALA   A CA  1 
ATOM   151  C C   . ALA   A 1 29  ? -21.162 -17.551 -2.979  1.00 37.00 ? 722  ALA   A C   1 
ATOM   152  O O   . ALA   A 1 29  ? -20.239 -17.895 -3.725  1.00 36.97 ? 722  ALA   A O   1 
ATOM   153  C CB  . ALA   A 1 29  ? -20.719 -17.441 -0.497  1.00 37.21 ? 722  ALA   A CB  1 
ATOM   154  N N   . PHE   A 1 30  ? -22.424 -17.930 -3.182  1.00 36.78 ? 723  PHE   A N   1 
ATOM   155  C CA  . PHE   A 1 30  ? -22.806 -18.791 -4.287  1.00 36.92 ? 723  PHE   A CA  1 
ATOM   156  C C   . PHE   A 1 30  ? -23.907 -18.128 -5.123  1.00 36.98 ? 723  PHE   A C   1 
ATOM   157  O O   . PHE   A 1 30  ? -24.876 -18.792 -5.494  1.00 37.32 ? 723  PHE   A O   1 
ATOM   158  C CB  . PHE   A 1 30  ? -23.260 -20.159 -3.754  1.00 36.84 ? 723  PHE   A CB  1 
ATOM   159  N N   . GLY   A 1 31  ? -23.742 -16.833 -5.414  1.00 36.40 ? 724  GLY   A N   1 
ATOM   160  C CA  . GLY   A 1 31  ? -24.697 -16.063 -6.212  1.00 36.28 ? 724  GLY   A CA  1 
ATOM   161  C C   . GLY   A 1 31  ? -24.603 -14.564 -6.004  1.00 35.81 ? 724  GLY   A C   1 
ATOM   162  O O   . GLY   A 1 31  ? -23.620 -14.101 -5.428  1.00 36.12 ? 724  GLY   A O   1 
ATOM   163  N N   . THR   A 1 32  ? -25.613 -13.781 -6.475  1.00 34.81 ? 725  THR   A N   1 
ATOM   164  C CA  . THR   A 1 32  ? -25.667 -12.305 -6.313  1.00 34.24 ? 725  THR   A CA  1 
ATOM   165  C C   . THR   A 1 32  ? -27.073 -11.824 -5.889  1.00 33.22 ? 725  THR   A C   1 
ATOM   166  O O   . THR   A 1 32  ? -28.062 -12.323 -6.414  1.00 33.56 ? 725  THR   A O   1 
ATOM   167  C CB  . THR   A 1 32  ? -25.188 -11.589 -7.591  1.00 35.39 ? 725  THR   A CB  1 
ATOM   168  O OG1 . THR   A 1 32  ? -23.800 -11.844 -7.769  1.00 36.58 ? 725  THR   A OG1 1 
ATOM   169  C CG2 . THR   A 1 32  ? -25.407 -10.084 -7.550  1.00 35.57 ? 725  THR   A CG2 1 
ATOM   170  N N   . VAL   A 1 33  ? -27.168 -10.874 -4.945  1.00 31.94 ? 726  VAL   A N   1 
ATOM   171  C CA  . VAL   A 1 33  ? -28.468 -10.378 -4.494  1.00 31.30 ? 726  VAL   A CA  1 
ATOM   172  C C   . VAL   A 1 33  ? -28.801 -9.022  -5.069  1.00 30.64 ? 726  VAL   A C   1 
ATOM   173  O O   . VAL   A 1 33  ? -28.053 -8.072  -4.875  1.00 30.70 ? 726  VAL   A O   1 
ATOM   174  C CB  . VAL   A 1 33  ? -28.568 -10.353 -2.976  1.00 31.96 ? 726  VAL   A CB  1 
ATOM   175  C CG1 . VAL   A 1 33  ? -29.944 -9.868  -2.544  1.00 32.41 ? 726  VAL   A CG1 1 
ATOM   176  C CG2 . VAL   A 1 33  ? -28.256 -11.725 -2.395  1.00 32.62 ? 726  VAL   A CG2 1 
ATOM   177  N N   . TYR   A 1 34  ? -29.961 -8.926  -5.726  1.00 29.83 ? 727  TYR   A N   1 
ATOM   178  C CA  . TYR   A 1 34  ? -30.449 -7.743  -6.427  1.00 29.35 ? 727  TYR   A CA  1 
ATOM   179  C C   . TYR   A 1 34  ? -31.711 -7.136  -5.811  1.00 28.17 ? 727  TYR   A C   1 
ATOM   180  O O   . TYR   A 1 34  ? -32.488 -7.828  -5.174  1.00 28.21 ? 727  TYR   A O   1 
ATOM   181  C CB  . TYR   A 1 34  ? -30.811 -8.139  -7.871  1.00 29.60 ? 727  TYR   A CB  1 
ATOM   182  C CG  . TYR   A 1 34  ? -29.687 -8.662  -8.746  1.00 30.49 ? 727  TYR   A CG  1 
ATOM   183  C CD1 . TYR   A 1 34  ? -29.363 -10.010 -8.764  1.00 31.33 ? 727  TYR   A CD1 1 
ATOM   184  C CD2 . TYR   A 1 34  ? -29.062 -7.838  -9.669  1.00 31.37 ? 727  TYR   A CD2 1 
ATOM   185  C CE1 . TYR   A 1 34  ? -28.367 -10.502 -9.593  1.00 32.30 ? 727  TYR   A CE1 1 
ATOM   186  C CE2 . TYR   A 1 34  ? -28.064 -8.316  -10.502 1.00 32.35 ? 727  TYR   A CE2 1 
ATOM   187  C CZ  . TYR   A 1 34  ? -27.714 -9.651  -10.461 1.00 33.42 ? 727  TYR   A CZ  1 
ATOM   188  O OH  . TYR   A 1 34  ? -26.749 -10.136 -11.321 1.00 35.26 ? 727  TYR   A OH  1 
ATOM   189  N N   . LYS   A 1 35  ? -31.932 -5.848  -6.073  1.00 27.07 ? 728  LYS   A N   1 
ATOM   190  C CA  . LYS   A 1 35  ? -33.106 -5.055  -5.714  1.00 26.32 ? 728  LYS   A CA  1 
ATOM   191  C C   . LYS   A 1 35  ? -33.862 -4.929  -7.024  1.00 26.32 ? 728  LYS   A C   1 
ATOM   192  O O   . LYS   A 1 35  ? -33.279 -4.459  -7.984  1.00 26.17 ? 728  LYS   A O   1 
ATOM   193  C CB  . LYS   A 1 35  ? -32.668 -3.641  -5.311  1.00 26.33 ? 728  LYS   A CB  1 
ATOM   194  C CG  . LYS   A 1 35  ? -32.627 -3.387  -3.828  1.00 26.83 ? 728  LYS   A CG  1 
ATOM   195  C CD  . LYS   A 1 35  ? -32.141 -1.988  -3.524  1.00 27.49 ? 728  LYS   A CD  1 
ATOM   196  C CE  . LYS   A 1 35  ? -30.679 -1.795  -3.820  1.00 28.63 ? 728  LYS   A CE  1 
ATOM   197  N NZ  . LYS   A 1 35  ? -30.258 -0.387  -3.602  1.00 29.59 ? 728  LYS   A NZ  1 
ATOM   198  N N   . GLY   A 1 36  ? -35.122 -5.336  -7.069  1.00 26.68 ? 729  GLY   A N   1 
ATOM   199  C CA  . GLY   A 1 36  ? -35.887 -5.295  -8.308  1.00 27.92 ? 729  GLY   A CA  1 
ATOM   200  C C   . GLY   A 1 36  ? -37.338 -4.888  -8.188  1.00 29.12 ? 729  GLY   A C   1 
ATOM   201  O O   . GLY   A 1 36  ? -37.760 -4.381  -7.153  1.00 28.89 ? 729  GLY   A O   1 
ATOM   202  N N   . LEU   A 1 37  ? -38.109 -5.110  -9.269  1.00 30.31 ? 730  LEU   A N   1 
ATOM   203  C CA  . LEU   A 1 37  ? -39.531 -4.761  -9.364  1.00 31.88 ? 730  LEU   A CA  1 
ATOM   204  C C   . LEU   A 1 37  ? -40.389 -5.964  -9.801  1.00 33.88 ? 730  LEU   A C   1 
ATOM   205  O O   . LEU   A 1 37  ? -39.877 -6.890  -10.412 1.00 33.66 ? 730  LEU   A O   1 
ATOM   206  C CB  . LEU   A 1 37  ? -39.702 -3.594  -10.352 1.00 31.67 ? 730  LEU   A CB  1 
ATOM   207  C CG  . LEU   A 1 37  ? -40.333 -2.304  -9.827  1.00 32.27 ? 730  LEU   A CG  1 
ATOM   208  C CD1 . LEU   A 1 37  ? -39.611 -1.777  -8.625  1.00 32.40 ? 730  LEU   A CD1 1 
ATOM   209  C CD2 . LEU   A 1 37  ? -40.330 -1.256  -10.885 1.00 32.71 ? 730  LEU   A CD2 1 
ATOM   210  N N   . TRP   A 1 38  ? -41.692 -5.936  -9.498  1.00 35.80 ? 731  TRP   A N   1 
ATOM   211  C CA  . TRP   A 1 38  ? -42.608 -7.032  -9.785  1.00 38.38 ? 731  TRP   A CA  1 
ATOM   212  C C   . TRP   A 1 38  ? -43.950 -6.567  -10.328 1.00 40.74 ? 731  TRP   A C   1 
ATOM   213  O O   . TRP   A 1 38  ? -44.765 -6.017  -9.602  1.00 40.59 ? 731  TRP   A O   1 
ATOM   214  C CB  . TRP   A 1 38  ? -42.833 -7.864  -8.515  1.00 38.85 ? 731  TRP   A CB  1 
ATOM   215  C CG  . TRP   A 1 38  ? -43.520 -9.185  -8.720  1.00 39.99 ? 731  TRP   A CG  1 
ATOM   216  C CD1 . TRP   A 1 38  ? -43.567 -9.924  -9.868  1.00 41.03 ? 731  TRP   A CD1 1 
ATOM   217  C CD2 . TRP   A 1 38  ? -44.166 -9.971  -7.710  1.00 40.36 ? 731  TRP   A CD2 1 
ATOM   218  N NE1 . TRP   A 1 38  ? -44.237 -11.105 -9.644  1.00 41.43 ? 731  TRP   A NE1 1 
ATOM   219  C CE2 . TRP   A 1 38  ? -44.596 -11.168 -8.319  1.00 41.23 ? 731  TRP   A CE2 1 
ATOM   220  C CE3 . TRP   A 1 38  ? -44.430 -9.774  -6.348  1.00 41.06 ? 731  TRP   A CE3 1 
ATOM   221  C CZ2 . TRP   A 1 38  ? -45.283 -12.159 -7.614  1.00 41.87 ? 731  TRP   A CZ2 1 
ATOM   222  C CZ3 . TRP   A 1 38  ? -45.087 -10.768 -5.646  1.00 41.98 ? 731  TRP   A CZ3 1 
ATOM   223  C CH2 . TRP   A 1 38  ? -45.517 -11.937 -6.279  1.00 42.09 ? 731  TRP   A CH2 1 
ATOM   224  N N   . ILE   A 1 39  ? -44.184 -6.832  -11.603 1.00 43.00 ? 732  ILE   A N   1 
ATOM   225  C CA  . ILE   A 1 39  ? -45.413 -6.532  -12.331 1.00 45.59 ? 732  ILE   A CA  1 
ATOM   226  C C   . ILE   A 1 39  ? -46.055 -7.908  -12.544 1.00 48.05 ? 732  ILE   A C   1 
ATOM   227  O O   . ILE   A 1 39  ? -45.722 -8.604  -13.509 1.00 48.07 ? 732  ILE   A O   1 
ATOM   228  C CB  . ILE   A 1 39  ? -45.115 -5.831  -13.697 1.00 46.46 ? 732  ILE   A CB  1 
ATOM   229  C CG1 . ILE   A 1 39  ? -43.902 -4.846  -13.644 1.00 47.41 ? 732  ILE   A CG1 1 
ATOM   230  C CG2 . ILE   A 1 39  ? -46.371 -5.136  -14.240 1.00 47.11 ? 732  ILE   A CG2 1 
ATOM   231  C CD1 . ILE   A 1 39  ? -42.540 -5.368  -14.232 1.00 48.50 ? 732  ILE   A CD1 1 
ATOM   232  N N   . PRO   A 1 40  ? -46.913 -8.351  -11.600 1.00 49.76 ? 733  PRO   A N   1 
ATOM   233  C CA  . PRO   A 1 40  ? -47.470 -9.718  -11.679 1.00 51.30 ? 733  PRO   A CA  1 
ATOM   234  C C   . PRO   A 1 40  ? -48.422 -10.003 -12.858 1.00 53.69 ? 733  PRO   A C   1 
ATOM   235  O O   . PRO   A 1 40  ? -48.662 -9.116  -13.686 1.00 53.90 ? 733  PRO   A O   1 
ATOM   236  C CB  . PRO   A 1 40  ? -48.161 -9.894  -10.317 1.00 51.49 ? 733  PRO   A CB  1 
ATOM   237  C CG  . PRO   A 1 40  ? -47.632 -8.780  -9.446  1.00 51.38 ? 733  PRO   A CG  1 
ATOM   238  C CD  . PRO   A 1 40  ? -47.351 -7.658  -10.374 1.00 49.39 ? 733  PRO   A CD  1 
ATOM   239  N N   . GLU   A 1 41  ? -48.929 -11.267 -12.954 1.00 55.24 ? 734  GLU   A N   1 
ATOM   240  C CA  . GLU   A 1 41  ? -49.834 -11.728 -14.022 1.00 57.28 ? 734  GLU   A CA  1 
ATOM   241  C C   . GLU   A 1 41  ? -51.137 -10.869 -14.149 1.00 58.81 ? 734  GLU   A C   1 
ATOM   242  O O   . GLU   A 1 41  ? -51.233 -10.020 -15.049 1.00 58.83 ? 734  GLU   A O   1 
ATOM   243  C CB  . GLU   A 1 41  ? -50.154 -13.240 -13.876 1.00 60.17 ? 734  GLU   A CB  1 
ATOM   244  C CG  . GLU   A 1 41  ? -48.944 -14.157 -13.898 1.00 66.61 ? 734  GLU   A CG  1 
ATOM   245  C CD  . GLU   A 1 41  ? -49.269 -15.642 -13.921 1.00 74.63 ? 734  GLU   A CD  1 
ATOM   246  O OE1 . GLU   A 1 41  ? -50.050 -16.067 -14.805 1.00 76.31 ? 734  GLU   A OE1 1 
ATOM   247  O OE2 . GLU   A 1 41  ? -48.734 -16.382 -13.062 1.00 76.95 ? 734  GLU   A OE2 1 
ATOM   248  N N   . GLY   A 1 42  ? -52.092 -11.071 -13.230 1.00 59.56 ? 735  GLY   A N   1 
ATOM   249  C CA  . GLY   A 1 42  ? -53.353 -10.336 -13.203 1.00 60.32 ? 735  GLY   A CA  1 
ATOM   250  C C   . GLY   A 1 42  ? -53.307 -9.168  -12.239 1.00 60.62 ? 735  GLY   A C   1 
ATOM   251  O O   . GLY   A 1 42  ? -54.177 -9.032  -11.372 1.00 60.90 ? 735  GLY   A O   1 
ATOM   252  N N   . GLU   A 1 43  ? -52.251 -8.341  -12.369 1.00 60.17 ? 736  GLU   A N   1 
ATOM   253  C CA  . GLU   A 1 43  ? -51.973 -7.149  -11.561 1.00 60.15 ? 736  GLU   A CA  1 
ATOM   254  C C   . GLU   A 1 43  ? -51.189 -6.158  -12.430 1.00 59.46 ? 736  GLU   A C   1 
ATOM   255  O O   . GLU   A 1 43  ? -50.363 -6.575  -13.249 1.00 59.44 ? 736  GLU   A O   1 
ATOM   256  C CB  . GLU   A 1 43  ? -51.145 -7.510  -10.308 1.00 62.55 ? 736  GLU   A CB  1 
ATOM   257  C CG  . GLU   A 1 43  ? -51.930 -8.173  -9.185  1.00 67.76 ? 736  GLU   A CG  1 
ATOM   258  C CD  . GLU   A 1 43  ? -51.394 -9.516  -8.719  1.00 74.52 ? 736  GLU   A CD  1 
ATOM   259  O OE1 . GLU   A 1 43  ? -50.629 -9.539  -7.725  1.00 75.32 ? 736  GLU   A OE1 1 
ATOM   260  O OE2 . GLU   A 1 43  ? -51.746 -10.548 -9.341  1.00 76.59 ? 736  GLU   A OE2 1 
ATOM   261  N N   . LYS   A 1 44  ? -51.452 -4.852  -12.270 1.00 58.75 ? 737  LYS   A N   1 
ATOM   262  C CA  . LYS   A 1 44  ? -50.757 -3.833  -13.069 1.00 58.43 ? 737  LYS   A CA  1 
ATOM   263  C C   . LYS   A 1 44  ? -49.772 -2.961  -12.259 1.00 57.53 ? 737  LYS   A C   1 
ATOM   264  O O   . LYS   A 1 44  ? -49.138 -2.067  -12.830 1.00 57.73 ? 737  LYS   A O   1 
ATOM   265  C CB  . LYS   A 1 44  ? -51.758 -2.953  -13.848 1.00 60.24 ? 737  LYS   A CB  1 
ATOM   266  C CG  . LYS   A 1 44  ? -51.545 -2.955  -15.363 1.00 64.07 ? 737  LYS   A CG  1 
ATOM   267  C CD  . LYS   A 1 44  ? -52.551 -2.040  -16.095 1.00 67.76 ? 737  LYS   A CD  1 
ATOM   268  C CE  . LYS   A 1 44  ? -52.533 -2.167  -17.609 1.00 69.85 ? 737  LYS   A CE  1 
ATOM   269  N NZ  . LYS   A 1 44  ? -51.375 -1.465  -18.221 1.00 70.97 ? 737  LYS   A NZ  1 
ATOM   270  N N   . VAL   A 1 45  ? -49.631 -3.227  -10.947 1.00 56.15 ? 738  VAL   A N   1 
ATOM   271  C CA  . VAL   A 1 45  ? -48.715 -2.478  -10.085 1.00 55.33 ? 738  VAL   A CA  1 
ATOM   272  C C   . VAL   A 1 45  ? -47.272 -2.998  -10.204 1.00 54.05 ? 738  VAL   A C   1 
ATOM   273  O O   . VAL   A 1 45  ? -47.054 -4.149  -10.599 1.00 54.46 ? 738  VAL   A O   1 
ATOM   274  C CB  . VAL   A 1 45  ? -49.191 -2.444  -8.608  1.00 56.03 ? 738  VAL   A CB  1 
ATOM   275  C CG1 . VAL   A 1 45  ? -50.663 -2.065  -8.514  1.00 56.74 ? 738  VAL   A CG1 1 
ATOM   276  C CG2 . VAL   A 1 45  ? -48.936 -3.771  -7.909  1.00 56.38 ? 738  VAL   A CG2 1 
ATOM   277  N N   . LYS   A 1 46  ? -46.284 -2.146  -9.883  1.00 52.25 ? 739  LYS   A N   1 
ATOM   278  C CA  . LYS   A 1 46  ? -44.882 -2.552  -9.955  1.00 50.88 ? 739  LYS   A CA  1 
ATOM   279  C C   . LYS   A 1 46  ? -44.240 -2.563  -8.556  1.00 49.32 ? 739  LYS   A C   1 
ATOM   280  O O   . LYS   A 1 46  ? -43.531 -1.628  -8.188  1.00 49.70 ? 739  LYS   A O   1 
ATOM   281  C CB  . LYS   A 1 46  ? -44.099 -1.676  -10.945 1.00 52.35 ? 739  LYS   A CB  1 
ATOM   282  C CG  . LYS   A 1 46  ? -44.763 -1.557  -12.313 1.00 56.20 ? 739  LYS   A CG  1 
ATOM   283  C CD  . LYS   A 1 46  ? -43.774 -1.090  -13.375 1.00 61.29 ? 739  LYS   A CD  1 
ATOM   284  C CE  . LYS   A 1 46  ? -44.428 -0.624  -14.666 1.00 65.83 ? 739  LYS   A CE  1 
ATOM   285  N NZ  . LYS   A 1 46  ? -44.981 -1.745  -15.483 1.00 68.22 ? 739  LYS   A NZ  1 
ATOM   286  N N   . ILE   A 1 47  ? -44.516 -3.633  -7.786  1.00 47.30 ? 740  ILE   A N   1 
ATOM   287  C CA  . ILE   A 1 47  ? -44.073 -3.898  -6.412  1.00 45.82 ? 740  ILE   A CA  1 
ATOM   288  C C   . ILE   A 1 47  ? -42.564 -3.996  -6.299  1.00 43.97 ? 740  ILE   A C   1 
ATOM   289  O O   . ILE   A 1 47  ? -41.988 -4.804  -7.009  1.00 44.16 ? 740  ILE   A O   1 
ATOM   290  C CB  . ILE   A 1 47  ? -44.638 -5.282  -5.997  1.00 46.44 ? 740  ILE   A CB  1 
ATOM   291  C CG1 . ILE   A 1 47  ? -46.151 -5.401  -6.220  1.00 47.66 ? 740  ILE   A CG1 1 
ATOM   292  C CG2 . ILE   A 1 47  ? -44.252 -5.654  -4.571  1.00 46.73 ? 740  ILE   A CG2 1 
ATOM   293  C CD1 . ILE   A 1 47  ? -46.597 -6.841  -6.458  1.00 49.06 ? 740  ILE   A CD1 1 
ATOM   294  N N   . PRO   A 1 48  ? -41.906 -3.317  -5.344  1.00 42.17 ? 741  PRO   A N   1 
ATOM   295  C CA  . PRO   A 1 48  ? -40.454 -3.513  -5.183  1.00 41.13 ? 741  PRO   A CA  1 
ATOM   296  C C   . PRO   A 1 48  ? -40.148 -4.847  -4.493  1.00 40.14 ? 741  PRO   A C   1 
ATOM   297  O O   . PRO   A 1 48  ? -40.747 -5.158  -3.470  1.00 40.43 ? 741  PRO   A O   1 
ATOM   298  C CB  . PRO   A 1 48  ? -40.021 -2.313  -4.342  1.00 42.00 ? 741  PRO   A CB  1 
ATOM   299  C CG  . PRO   A 1 48  ? -41.237 -1.905  -3.593  1.00 42.74 ? 741  PRO   A CG  1 
ATOM   300  C CD  . PRO   A 1 48  ? -42.447 -2.339  -4.382  1.00 41.49 ? 741  PRO   A CD  1 
ATOM   301  N N   . VAL   A 1 49  ? -39.259 -5.660  -5.069  1.00 39.04 ? 742  VAL   A N   1 
ATOM   302  C CA  . VAL   A 1 49  ? -38.910 -6.970  -4.509  1.00 38.61 ? 742  VAL   A CA  1 
ATOM   303  C C   . VAL   A 1 49  ? -37.381 -7.162  -4.356  1.00 37.74 ? 742  VAL   A C   1 
ATOM   304  O O   . VAL   A 1 49  ? -36.602 -6.336  -4.822  1.00 37.87 ? 742  VAL   A O   1 
ATOM   305  C CB  . VAL   A 1 49  ? -39.554 -8.135  -5.323  1.00 39.42 ? 742  VAL   A CB  1 
ATOM   306  C CG1 . VAL   A 1 49  ? -41.069 -8.169  -5.160  1.00 40.25 ? 742  VAL   A CG1 1 
ATOM   307  C CG2 . VAL   A 1 49  ? -39.142 -8.089  -6.789  1.00 39.62 ? 742  VAL   A CG2 1 
ATOM   308  N N   . ALA   A 1 50  ? -36.964 -8.244  -3.680  1.00 36.61 ? 743  ALA   A N   1 
ATOM   309  C CA  . ALA   A 1 50  ? -35.581 -8.642  -3.498  1.00 35.99 ? 743  ALA   A CA  1 
ATOM   310  C C   . ALA   A 1 50  ? -35.369 -9.926  -4.316  1.00 34.82 ? 743  ALA   A C   1 
ATOM   311  O O   . ALA   A 1 50  ? -36.077 -10.912 -4.106  1.00 34.96 ? 743  ALA   A O   1 
ATOM   312  C CB  . ALA   A 1 50  ? -35.318 -8.914  -2.030  1.00 36.37 ? 743  ALA   A CB  1 
ATOM   313  N N   . ILE   A 1 51  ? -34.416 -9.912  -5.256  1.00 33.40 ? 744  ILE   A N   1 
ATOM   314  C CA  . ILE   A 1 51  ? -34.167 -11.074 -6.105  1.00 32.57 ? 744  ILE   A CA  1 
ATOM   315  C C   . ILE   A 1 51  ? -32.822 -11.728 -5.821  1.00 31.92 ? 744  ILE   A C   1 
ATOM   316  O O   . ILE   A 1 51  ? -31.814 -11.043 -5.729  1.00 31.58 ? 744  ILE   A O   1 
ATOM   317  C CB  . ILE   A 1 51  ? -34.333 -10.745 -7.609  1.00 32.70 ? 744  ILE   A CB  1 
ATOM   318  C CG1 . ILE   A 1 51  ? -35.574 -9.857  -7.876  1.00 33.17 ? 744  ILE   A CG1 1 
ATOM   319  C CG2 . ILE   A 1 51  ? -34.403 -12.044 -8.411  1.00 33.13 ? 744  ILE   A CG2 1 
ATOM   320  C CD1 . ILE   A 1 51  ? -35.519 -9.083  -9.077  1.00 34.07 ? 744  ILE   A CD1 1 
ATOM   321  N N   . LYS   A 1 52  ? -32.805 -13.054 -5.684  1.00 31.64 ? 745  LYS   A N   1 
ATOM   322  C CA  . LYS   A 1 52  ? -31.570 -13.782 -5.424  1.00 31.82 ? 745  LYS   A CA  1 
ATOM   323  C C   . LYS   A 1 52  ? -31.198 -14.639 -6.615  1.00 31.96 ? 745  LYS   A C   1 
ATOM   324  O O   . LYS   A 1 52  ? -31.740 -15.731 -6.775  1.00 31.77 ? 745  LYS   A O   1 
ATOM   325  C CB  . LYS   A 1 52  ? -31.699 -14.676 -4.185  1.00 33.04 ? 745  LYS   A CB  1 
ATOM   326  C CG  . LYS   A 1 52  ? -30.507 -14.600 -3.246  1.00 36.36 ? 745  LYS   A CG  1 
ATOM   327  C CD  . LYS   A 1 52  ? -29.399 -15.581 -3.598  1.00 40.66 ? 745  LYS   A CD  1 
ATOM   328  C CE  . LYS   A 1 52  ? -28.234 -15.499 -2.625  1.00 44.58 ? 745  LYS   A CE  1 
ATOM   329  N NZ  . LYS   A 1 52  ? -28.580 -15.953 -1.236  1.00 46.47 ? 745  LYS   A NZ  1 
ATOM   330  N N   . GLU   A 1 53  ? -30.263 -14.164 -7.434  1.00 31.95 ? 746  GLU   A N   1 
ATOM   331  C CA  . GLU   A 1 53  ? -29.788 -14.940 -8.560  1.00 32.48 ? 746  GLU   A CA  1 
ATOM   332  C C   . GLU   A 1 53  ? -28.739 -15.898 -8.039  1.00 32.40 ? 746  GLU   A C   1 
ATOM   333  O O   . GLU   A 1 53  ? -27.756 -15.471 -7.439  1.00 31.93 ? 746  GLU   A O   1 
ATOM   334  C CB  . GLU   A 1 53  ? -29.199 -14.034 -9.647  1.00 35.04 ? 746  GLU   A CB  1 
ATOM   335  C CG  . GLU   A 1 53  ? -28.556 -14.791 -10.792 1.00 40.66 ? 746  GLU   A CG  1 
ATOM   336  C CD  . GLU   A 1 53  ? -28.316 -13.936 -12.021 1.00 48.97 ? 746  GLU   A CD  1 
ATOM   337  O OE1 . GLU   A 1 53  ? -27.372 -13.112 -11.997 1.00 50.83 ? 746  GLU   A OE1 1 
ATOM   338  O OE2 . GLU   A 1 53  ? -29.079 -14.080 -13.005 1.00 51.40 ? 746  GLU   A OE2 1 
ATOM   339  N N   . LEU   A 1 54  ? -28.960 -17.190 -8.243  1.00 32.66 ? 747  LEU   A N   1 
ATOM   340  C CA  . LEU   A 1 54  ? -28.001 -18.202 -7.837  1.00 33.37 ? 747  LEU   A CA  1 
ATOM   341  C C   . LEU   A 1 54  ? -27.218 -18.637 -9.078  1.00 34.51 ? 747  LEU   A C   1 
ATOM   342  O O   . LEU   A 1 54  ? -27.814 -18.896 -10.119 1.00 34.13 ? 747  LEU   A O   1 
ATOM   343  C CB  . LEU   A 1 54  ? -28.712 -19.391 -7.184  1.00 33.22 ? 747  LEU   A CB  1 
ATOM   344  C CG  . LEU   A 1 54  ? -29.305 -19.096 -5.820  1.00 34.61 ? 747  LEU   A CG  1 
ATOM   345  C CD1 . LEU   A 1 54  ? -30.526 -19.932 -5.559  1.00 35.18 ? 747  LEU   A CD1 1 
ATOM   346  C CD2 . LEU   A 1 54  ? -28.275 -19.276 -4.723  1.00 35.15 ? 747  LEU   A CD2 1 
ATOM   347  N N   . ARG   A 1 55  ? -25.880 -18.688 -8.960  1.00 35.49 ? 748  ARG   A N   1 
ATOM   348  C CA  . ARG   A 1 55  ? -24.929 -19.068 -10.007 1.00 36.62 ? 748  ARG   A CA  1 
ATOM   349  C C   . ARG   A 1 55  ? -25.323 -20.383 -10.691 1.00 36.73 ? 748  ARG   A C   1 
ATOM   350  O O   . ARG   A 1 55  ? -25.953 -21.246 -10.066 1.00 36.75 ? 748  ARG   A O   1 
ATOM   351  C CB  . ARG   A 1 55  ? -23.511 -19.169 -9.401  1.00 39.11 ? 748  ARG   A CB  1 
ATOM   352  C CG  . ARG   A 1 55  ? -22.369 -18.975 -10.396 1.00 44.12 ? 748  ARG   A CG  1 
ATOM   353  C CD  . ARG   A 1 55  ? -21.039 -19.418 -9.804  1.00 49.06 ? 748  ARG   A CD  1 
ATOM   354  N NE  . ARG   A 1 55  ? -20.989 -20.872 -9.603  1.00 53.56 ? 748  ARG   A NE  1 
ATOM   355  C CZ  . ARG   A 1 55  ? -20.459 -21.735 -10.469 1.00 56.15 ? 748  ARG   A CZ  1 
ATOM   356  N NH1 . ARG   A 1 55  ? -20.467 -23.036 -10.207 1.00 55.84 ? 748  ARG   A NH1 1 
ATOM   357  N NH2 . ARG   A 1 55  ? -19.911 -21.302 -11.599 1.00 55.64 ? 748  ARG   A NH2 1 
ATOM   358  N N   . GLU   A 1 56  ? -24.964 -20.527 -11.978 1.00 36.62 ? 749  GLU   A N   1 
ATOM   359  C CA  . GLU   A 1 56  ? -25.307 -21.717 -12.748 1.00 36.93 ? 749  GLU   A CA  1 
ATOM   360  C C   . GLU   A 1 56  ? -24.593 -22.981 -12.268 1.00 37.60 ? 749  GLU   A C   1 
ATOM   361  O O   . GLU   A 1 56  ? -23.521 -22.893 -11.672 1.00 37.51 ? 749  GLU   A O   1 
ATOM   362  C CB  . GLU   A 1 56  ? -25.072 -21.481 -14.239 1.00 38.27 ? 749  GLU   A CB  1 
ATOM   363  C CG  . GLU   A 1 56  ? -26.165 -22.096 -15.089 1.00 41.25 ? 749  GLU   A CG  1 
ATOM   364  C CD  . GLU   A 1 56  ? -26.255 -21.624 -16.524 1.00 44.06 ? 749  GLU   A CD  1 
ATOM   365  O OE1 . GLU   A 1 56  ? -25.798 -20.497 -16.822 1.00 44.64 ? 749  GLU   A OE1 1 
ATOM   366  O OE2 . GLU   A 1 56  ? -26.792 -22.388 -17.356 1.00 44.93 ? 749  GLU   A OE2 1 
ATOM   367  N N   . ALA   A 1 57  ? -25.226 -24.153 -12.482 1.00 38.09 ? 750  ALA   A N   1 
ATOM   368  C CA  . ALA   A 1 57  ? -24.736 -25.485 -12.100 1.00 39.22 ? 750  ALA   A CA  1 
ATOM   369  C C   . ALA   A 1 57  ? -24.311 -25.613 -10.638 1.00 40.55 ? 750  ALA   A C   1 
ATOM   370  O O   . ALA   A 1 57  ? -23.497 -26.479 -10.297 1.00 40.61 ? 750  ALA   A O   1 
ATOM   371  C CB  . ALA   A 1 57  ? -23.612 -25.934 -13.020 1.00 39.30 ? 750  ALA   A CB  1 
ATOM   372  N N   . THR   A 1 58  ? -24.866 -24.747 -9.775  1.00 41.32 ? 751  THR   A N   1 
ATOM   373  C CA  . THR   A 1 58  ? -24.585 -24.738 -8.345  1.00 42.17 ? 751  THR   A CA  1 
ATOM   374  C C   . THR   A 1 58  ? -25.363 -25.858 -7.671  1.00 43.25 ? 751  THR   A C   1 
ATOM   375  O O   . THR   A 1 58  ? -24.801 -26.626 -6.885  1.00 43.23 ? 751  THR   A O   1 
ATOM   376  C CB  . THR   A 1 58  ? -24.926 -23.365 -7.762  1.00 42.80 ? 751  THR   A CB  1 
ATOM   377  O OG1 . THR   A 1 58  ? -23.997 -22.412 -8.273  1.00 43.33 ? 751  THR   A OG1 1 
ATOM   378  C CG2 . THR   A 1 58  ? -24.900 -23.360 -6.244  1.00 43.10 ? 751  THR   A CG2 1 
ATOM   379  N N   . SER   A 1 59  ? -26.651 -25.976 -8.011  1.00 43.97 ? 752  SER   A N   1 
ATOM   380  C CA  . SER   A 1 59  ? -27.502 -26.999 -7.432  1.00 45.29 ? 752  SER   A CA  1 
ATOM   381  C C   . SER   A 1 59  ? -27.327 -28.303 -8.150  1.00 45.66 ? 752  SER   A C   1 
ATOM   382  O O   . SER   A 1 59  ? -27.541 -28.366 -9.353  1.00 46.08 ? 752  SER   A O   1 
ATOM   383  C CB  . SER   A 1 59  ? -28.966 -26.584 -7.514  1.00 47.41 ? 752  SER   A CB  1 
ATOM   384  O OG  . SER   A 1 59  ? -29.773 -27.457 -6.739  1.00 50.36 ? 752  SER   A OG  1 
ATOM   385  N N   . PRO   A 1 60  ? -27.037 -29.386 -7.422  1.00 45.64 ? 753  PRO   A N   1 
ATOM   386  C CA  . PRO   A 1 60  ? -26.887 -30.692 -8.080  1.00 45.90 ? 753  PRO   A CA  1 
ATOM   387  C C   . PRO   A 1 60  ? -28.231 -31.377 -8.383  1.00 46.40 ? 753  PRO   A C   1 
ATOM   388  O O   . PRO   A 1 60  ? -28.352 -32.598 -8.252  1.00 46.74 ? 753  PRO   A O   1 
ATOM   389  C CB  . PRO   A 1 60  ? -26.031 -31.494 -7.086  1.00 46.44 ? 753  PRO   A CB  1 
ATOM   390  C CG  . PRO   A 1 60  ? -25.688 -30.524 -5.951  1.00 46.64 ? 753  PRO   A CG  1 
ATOM   391  C CD  . PRO   A 1 60  ? -26.746 -29.477 -5.983  1.00 44.95 ? 753  PRO   A CD  1 
ATOM   392  N N   . LYS   A 1 61  ? -29.250 -30.574 -8.753  1.00 46.15 ? 754  LYS   A N   1 
ATOM   393  C CA  . LYS   A 1 61  ? -30.603 -31.009 -9.098  1.00 46.42 ? 754  LYS   A CA  1 
ATOM   394  C C   . LYS   A 1 61  ? -31.067 -30.299 -10.371 1.00 47.24 ? 754  LYS   A C   1 
ATOM   395  O O   . LYS   A 1 61  ? -30.572 -29.218 -10.705 1.00 47.32 ? 754  LYS   A O   1 
ATOM   396  C CB  . LYS   A 1 61  ? -31.599 -30.688 -7.965  1.00 47.33 ? 754  LYS   A CB  1 
ATOM   397  C CG  . LYS   A 1 61  ? -31.324 -31.393 -6.643  1.00 50.10 ? 754  LYS   A CG  1 
ATOM   398  C CD  . LYS   A 1 61  ? -30.605 -30.473 -5.657  1.00 53.06 ? 754  LYS   A CD  1 
ATOM   399  C CE  . LYS   A 1 61  ? -30.346 -31.091 -4.306  1.00 55.56 ? 754  LYS   A CE  1 
ATOM   400  N NZ  . LYS   A 1 61  ? -29.322 -30.324 -3.554  1.00 56.94 ? 754  LYS   A NZ  1 
ATOM   401  N N   . ALA   A 1 62  ? -32.023 -30.899 -11.080 1.00 47.76 ? 755  ALA   A N   1 
ATOM   402  C CA  . ALA   A 1 62  ? -32.583 -30.266 -12.276 1.00 48.77 ? 755  ALA   A CA  1 
ATOM   403  C C   . ALA   A 1 62  ? -33.657 -29.254 -11.847 1.00 49.32 ? 755  ALA   A C   1 
ATOM   404  O O   . ALA   A 1 62  ? -34.134 -29.316 -10.717 1.00 49.06 ? 755  ALA   A O   1 
ATOM   405  C CB  . ALA   A 1 62  ? -33.171 -31.319 -13.213 1.00 49.07 ? 755  ALA   A CB  1 
ATOM   406  N N   . ASN   A 1 63  ? -34.049 -28.331 -12.739 1.00 49.88 ? 756  ASN   A N   1 
ATOM   407  C CA  . ASN   A 1 63  ? -35.058 -27.328 -12.409 1.00 50.83 ? 756  ASN   A CA  1 
ATOM   408  C C   . ASN   A 1 63  ? -36.379 -27.931 -11.948 1.00 51.90 ? 756  ASN   A C   1 
ATOM   409  O O   . ASN   A 1 63  ? -37.061 -27.307 -11.143 1.00 52.21 ? 756  ASN   A O   1 
ATOM   410  C CB  . ASN   A 1 63  ? -35.281 -26.346 -13.558 1.00 51.54 ? 756  ASN   A CB  1 
ATOM   411  C CG  . ASN   A 1 63  ? -34.077 -25.526 -13.958 1.00 54.19 ? 756  ASN   A CG  1 
ATOM   412  O OD1 . ASN   A 1 63  ? -34.042 -24.966 -15.049 1.00 55.47 ? 756  ASN   A OD1 1 
ATOM   413  N ND2 . ASN   A 1 63  ? -33.063 -25.420 -13.105 1.00 54.62 ? 756  ASN   A ND2 1 
ATOM   414  N N   . LYS   A 1 64  ? -36.733 -29.140 -12.419 1.00 52.36 ? 757  LYS   A N   1 
ATOM   415  C CA  . LYS   A 1 64  ? -37.976 -29.767 -11.974 1.00 53.36 ? 757  LYS   A CA  1 
ATOM   416  C C   . LYS   A 1 64  ? -37.833 -30.351 -10.565 1.00 53.83 ? 757  LYS   A C   1 
ATOM   417  O O   . LYS   A 1 64  ? -38.795 -30.332 -9.804  1.00 53.98 ? 757  LYS   A O   1 
ATOM   418  C CB  . LYS   A 1 64  ? -38.524 -30.776 -12.990 1.00 55.79 ? 757  LYS   A CB  1 
ATOM   419  C CG  . LYS   A 1 64  ? -40.050 -30.928 -12.925 1.00 60.28 ? 757  LYS   A CG  1 
ATOM   420  C CD  . LYS   A 1 64  ? -40.812 -29.624 -13.211 1.00 64.50 ? 757  LYS   A CD  1 
ATOM   421  C CE  . LYS   A 1 64  ? -42.261 -29.704 -12.784 1.00 68.16 ? 757  LYS   A CE  1 
ATOM   422  N NZ  . LYS   A 1 64  ? -42.403 -30.018 -11.331 1.00 70.33 ? 757  LYS   A NZ  1 
ATOM   423  N N   . GLU   A 1 65  ? -36.624 -30.808 -10.192 1.00 53.86 ? 758  GLU   A N   1 
ATOM   424  C CA  . GLU   A 1 65  ? -36.360 -31.288 -8.833  1.00 54.18 ? 758  GLU   A CA  1 
ATOM   425  C C   . GLU   A 1 65  ? -36.302 -30.095 -7.884  1.00 54.17 ? 758  GLU   A C   1 
ATOM   426  O O   . GLU   A 1 65  ? -36.841 -30.168 -6.783  1.00 54.38 ? 758  GLU   A O   1 
ATOM   427  C CB  . GLU   A 1 65  ? -35.043 -32.076 -8.755  1.00 56.43 ? 758  GLU   A CB  1 
ATOM   428  C CG  . GLU   A 1 65  ? -35.133 -33.487 -9.305  1.00 60.60 ? 758  GLU   A CG  1 
ATOM   429  C CD  . GLU   A 1 65  ? -34.786 -33.592 -10.775 1.00 65.48 ? 758  GLU   A CD  1 
ATOM   430  O OE1 . GLU   A 1 65  ? -35.649 -33.247 -11.615 1.00 66.51 ? 758  GLU   A OE1 1 
ATOM   431  O OE2 . GLU   A 1 65  ? -33.649 -34.017 -11.087 1.00 66.67 ? 758  GLU   A OE2 1 
ATOM   432  N N   . ILE   A 1 66  ? -35.656 -28.996 -8.316  1.00 53.90 ? 759  ILE   A N   1 
ATOM   433  C CA  . ILE   A 1 66  ? -35.552 -27.757 -7.556  1.00 54.30 ? 759  ILE   A CA  1 
ATOM   434  C C   . ILE   A 1 66  ? -36.947 -27.188 -7.329  1.00 55.23 ? 759  ILE   A C   1 
ATOM   435  O O   . ILE   A 1 66  ? -37.247 -26.772 -6.218  1.00 55.24 ? 759  ILE   A O   1 
ATOM   436  C CB  . ILE   A 1 66  ? -34.631 -26.742 -8.275  1.00 54.45 ? 759  ILE   A CB  1 
ATOM   437  C CG1 . ILE   A 1 66  ? -33.177 -27.237 -8.312  1.00 55.16 ? 759  ILE   A CG1 1 
ATOM   438  C CG2 . ILE   A 1 66  ? -34.720 -25.362 -7.634  1.00 54.82 ? 759  ILE   A CG2 1 
ATOM   439  C CD1 . ILE   A 1 66  ? -32.264 -26.410 -9.195  1.00 56.17 ? 759  ILE   A CD1 1 
ATOM   440  N N   . LEU   A 1 67  ? -37.812 -27.217 -8.357  1.00 55.95 ? 760  LEU   A N   1 
ATOM   441  C CA  . LEU   A 1 67  ? -39.181 -26.718 -8.247  1.00 57.32 ? 760  LEU   A CA  1 
ATOM   442  C C   . LEU   A 1 67  ? -39.977 -27.433 -7.153  1.00 59.04 ? 760  LEU   A C   1 
ATOM   443  O O   . LEU   A 1 67  ? -40.478 -26.785 -6.230  1.00 59.38 ? 760  LEU   A O   1 
ATOM   444  C CB  . LEU   A 1 67  ? -39.919 -26.820 -9.585  1.00 57.39 ? 760  LEU   A CB  1 
ATOM   445  C CG  . LEU   A 1 67  ? -41.259 -26.127 -9.589  1.00 58.87 ? 760  LEU   A CG  1 
ATOM   446  C CD1 . LEU   A 1 67  ? -41.079 -24.631 -9.543  1.00 59.51 ? 760  LEU   A CD1 1 
ATOM   447  C CD2 . LEU   A 1 67  ? -42.084 -26.533 -10.785 1.00 59.47 ? 760  LEU   A CD2 1 
ATOM   448  N N   . ASP   A 1 68  ? -40.031 -28.769 -7.211  1.00 59.77 ? 761  ASP   A N   1 
ATOM   449  C CA  . ASP   A 1 68  ? -40.760 -29.580 -6.239  1.00 60.63 ? 761  ASP   A CA  1 
ATOM   450  C C   . ASP   A 1 68  ? -40.213 -29.428 -4.821  1.00 60.98 ? 761  ASP   A C   1 
ATOM   451  O O   . ASP   A 1 68  ? -40.984 -29.489 -3.863  1.00 61.16 ? 761  ASP   A O   1 
ATOM   452  C CB  . ASP   A 1 68  ? -40.819 -31.045 -6.701  1.00 62.62 ? 761  ASP   A CB  1 
ATOM   453  C CG  . ASP   A 1 68  ? -41.273 -31.169 -8.152  1.00 67.82 ? 761  ASP   A CG  1 
ATOM   454  O OD1 . ASP   A 1 68  ? -42.020 -30.273 -8.625  1.00 68.36 ? 761  ASP   A OD1 1 
ATOM   455  O OD2 . ASP   A 1 68  ? -40.844 -32.129 -8.829  1.00 70.47 ? 761  ASP   A OD2 1 
ATOM   456  N N   . GLU   A 1 69  ? -38.906 -29.160 -4.683  1.00 61.05 ? 762  GLU   A N   1 
ATOM   457  C CA  . GLU   A 1 69  ? -38.316 -28.929 -3.361  1.00 61.65 ? 762  GLU   A CA  1 
ATOM   458  C C   . GLU   A 1 69  ? -38.631 -27.508 -2.868  1.00 61.60 ? 762  GLU   A C   1 
ATOM   459  O O   . GLU   A 1 69  ? -38.819 -27.303 -1.672  1.00 61.69 ? 762  GLU   A O   1 
ATOM   460  C CB  . GLU   A 1 69  ? -36.804 -29.179 -3.369  1.00 64.19 ? 762  GLU   A CB  1 
ATOM   461  C CG  . GLU   A 1 69  ? -36.221 -29.294 -1.976  1.00 69.36 ? 762  GLU   A CG  1 
ATOM   462  C CD  . GLU   A 1 69  ? -34.754 -28.937 -1.905  1.00 75.84 ? 762  GLU   A CD  1 
ATOM   463  O OE1 . GLU   A 1 69  ? -34.001 -29.334 -2.824  1.00 76.95 ? 762  GLU   A OE1 1 
ATOM   464  O OE2 . GLU   A 1 69  ? -34.358 -28.254 -0.932  1.00 77.83 ? 762  GLU   A OE2 1 
ATOM   465  N N   . ALA   A 1 70  ? -38.718 -26.535 -3.788  1.00 61.33 ? 763  ALA   A N   1 
ATOM   466  C CA  . ALA   A 1 70  ? -39.090 -25.166 -3.450  1.00 61.60 ? 763  ALA   A CA  1 
ATOM   467  C C   . ALA   A 1 70  ? -40.581 -25.038 -3.094  1.00 62.00 ? 763  ALA   A C   1 
ATOM   468  O O   . ALA   A 1 70  ? -40.968 -24.033 -2.502  1.00 62.14 ? 763  ALA   A O   1 
ATOM   469  C CB  . ALA   A 1 70  ? -38.746 -24.229 -4.588  1.00 61.59 ? 763  ALA   A CB  1 
ATOM   470  N N   . TYR   A 1 71  ? -41.413 -26.047 -3.441  1.00 62.06 ? 764  TYR   A N   1 
ATOM   471  C CA  . TYR   A 1 71  ? -42.839 -26.080 -3.108  1.00 62.54 ? 764  TYR   A CA  1 
ATOM   472  C C   . TYR   A 1 71  ? -43.069 -26.262 -1.586  1.00 62.10 ? 764  TYR   A C   1 
ATOM   473  O O   . TYR   A 1 71  ? -44.066 -25.778 -1.047  1.00 62.19 ? 764  TYR   A O   1 
ATOM   474  C CB  . TYR   A 1 71  ? -43.559 -27.184 -3.904  1.00 62.96 ? 764  TYR   A CB  1 
ATOM   475  C CG  . TYR   A 1 71  ? -44.116 -26.717 -5.231  1.00 64.09 ? 764  TYR   A CG  1 
ATOM   476  C CD1 . TYR   A 1 71  ? -44.993 -25.646 -5.301  1.00 65.05 ? 764  TYR   A CD1 1 
ATOM   477  C CD2 . TYR   A 1 71  ? -43.826 -27.395 -6.405  1.00 65.31 ? 764  TYR   A CD2 1 
ATOM   478  C CE1 . TYR   A 1 71  ? -45.524 -25.224 -6.511  1.00 66.23 ? 764  TYR   A CE1 1 
ATOM   479  C CE2 . TYR   A 1 71  ? -44.348 -26.983 -7.623  1.00 66.51 ? 764  TYR   A CE2 1 
ATOM   480  C CZ  . TYR   A 1 71  ? -45.198 -25.894 -7.674  1.00 67.62 ? 764  TYR   A CZ  1 
ATOM   481  O OH  . TYR   A 1 71  ? -45.721 -25.483 -8.882  1.00 69.63 ? 764  TYR   A OH  1 
ATOM   482  N N   . VAL   A 1 72  ? -42.146 -26.949 -0.897  1.00 61.41 ? 765  VAL   A N   1 
ATOM   483  C CA  . VAL   A 1 72  ? -42.252 -27.135 0.547   1.00 61.26 ? 765  VAL   A CA  1 
ATOM   484  C C   . VAL   A 1 72  ? -41.728 -25.899 1.297   1.00 60.78 ? 765  VAL   A C   1 
ATOM   485  O O   . VAL   A 1 72  ? -42.286 -25.535 2.329   1.00 60.84 ? 765  VAL   A O   1 
ATOM   486  C CB  . VAL   A 1 72  ? -41.614 -28.459 1.014   1.00 62.22 ? 765  VAL   A CB  1 
ATOM   487  C CG1 . VAL   A 1 72  ? -41.852 -28.689 2.502   1.00 62.89 ? 765  VAL   A CG1 1 
ATOM   488  C CG2 . VAL   A 1 72  ? -42.159 -29.628 0.200   1.00 62.79 ? 765  VAL   A CG2 1 
ATOM   489  N N   . MET   A 1 73  ? -40.740 -25.183 0.732   1.00 60.24 ? 766  MET   A N   1 
ATOM   490  C CA  . MET   A 1 73  ? -40.251 -23.923 1.322   1.00 60.22 ? 766  MET   A CA  1 
ATOM   491  C C   . MET   A 1 73  ? -41.284 -22.760 1.193   1.00 60.01 ? 766  MET   A C   1 
ATOM   492  O O   . MET   A 1 73  ? -41.037 -21.656 1.676   1.00 59.77 ? 766  MET   A O   1 
ATOM   493  C CB  . MET   A 1 73  ? -38.878 -23.530 0.743   1.00 60.93 ? 766  MET   A CB  1 
ATOM   494  C CG  . MET   A 1 73  ? -37.725 -24.399 1.247   1.00 63.54 ? 766  MET   A CG  1 
ATOM   495  S SD  . MET   A 1 73  ? -37.794 -26.166 0.784   1.00 68.85 ? 766  MET   A SD  1 
ATOM   496  C CE  . MET   A 1 73  ? -36.587 -26.863 1.922   1.00 66.56 ? 766  MET   A CE  1 
ATOM   497  N N   . ALA   A 1 74  ? -42.428 -23.031 0.518   1.00 59.99 ? 767  ALA   A N   1 
ATOM   498  C CA  . ALA   A 1 74  ? -43.616 -22.195 0.328   1.00 60.26 ? 767  ALA   A CA  1 
ATOM   499  C C   . ALA   A 1 74  ? -44.793 -22.742 1.198   1.00 60.34 ? 767  ALA   A C   1 
ATOM   500  O O   . ALA   A 1 74  ? -45.697 -21.986 1.553   1.00 60.39 ? 767  ALA   A O   1 
ATOM   501  C CB  . ALA   A 1 74  ? -44.010 -22.161 -1.139  1.00 60.26 ? 767  ALA   A CB  1 
ATOM   502  N N   . SER   A 1 75  ? -44.773 -24.053 1.535   1.00 60.12 ? 768  SER   A N   1 
ATOM   503  C CA  . SER   A 1 75  ? -45.713 -24.699 2.456   1.00 60.45 ? 768  SER   A CA  1 
ATOM   504  C C   . SER   A 1 75  ? -45.478 -24.153 3.890   1.00 60.12 ? 768  SER   A C   1 
ATOM   505  O O   . SER   A 1 75  ? -46.419 -24.059 4.674   1.00 60.27 ? 768  SER   A O   1 
ATOM   506  C CB  . SER   A 1 75  ? -45.533 -26.216 2.426   1.00 62.16 ? 768  SER   A CB  1 
ATOM   507  O OG  . SER   A 1 75  ? -46.267 -26.869 3.450   1.00 64.54 ? 768  SER   A OG  1 
ATOM   508  N N   . VAL   A 1 76  ? -44.219 -23.796 4.212   1.00 59.49 ? 769  VAL   A N   1 
ATOM   509  C CA  . VAL   A 1 76  ? -43.781 -23.150 5.442   1.00 59.27 ? 769  VAL   A CA  1 
ATOM   510  C C   . VAL   A 1 76  ? -44.529 -21.809 5.583   1.00 59.31 ? 769  VAL   A C   1 
ATOM   511  O O   . VAL   A 1 76  ? -45.025 -21.491 6.658   1.00 59.74 ? 769  VAL   A O   1 
ATOM   512  C CB  . VAL   A 1 76  ? -42.246 -22.957 5.354   1.00 59.63 ? 769  VAL   A CB  1 
ATOM   513  C CG1 . VAL   A 1 76  ? -41.742 -21.808 6.223   1.00 60.11 ? 769  VAL   A CG1 1 
ATOM   514  C CG2 . VAL   A 1 76  ? -41.525 -24.254 5.679   1.00 60.03 ? 769  VAL   A CG2 1 
ATOM   515  N N   . ASP   A 1 77  ? -44.664 -21.063 4.482   1.00 58.72 ? 770  ASP   A N   1 
ATOM   516  C CA  . ASP   A 1 77  ? -45.351 -19.774 4.414   1.00 58.65 ? 770  ASP   A CA  1 
ATOM   517  C C   . ASP   A 1 77  ? -46.834 -19.822 4.858   1.00 57.85 ? 770  ASP   A C   1 
ATOM   518  O O   . ASP   A 1 77  ? -47.439 -18.772 5.069   1.00 57.81 ? 770  ASP   A O   1 
ATOM   519  C CB  . ASP   A 1 77  ? -45.205 -19.180 2.998   1.00 60.83 ? 770  ASP   A CB  1 
ATOM   520  C CG  . ASP   A 1 77  ? -43.774 -19.158 2.470   1.00 65.64 ? 770  ASP   A CG  1 
ATOM   521  O OD1 . ASP   A 1 77  ? -42.835 -19.355 3.277   1.00 66.59 ? 770  ASP   A OD1 1 
ATOM   522  O OD2 . ASP   A 1 77  ? -43.594 -18.938 1.254   1.00 67.80 ? 770  ASP   A OD2 1 
ATOM   523  N N   . ASN   A 1 78  ? -47.398 -21.035 5.039   1.00 57.13 ? 771  ASN   A N   1 
ATOM   524  C CA  . ASN   A 1 78  ? -48.762 -21.268 5.521   1.00 57.11 ? 771  ASN   A CA  1 
ATOM   525  C C   . ASN   A 1 78  ? -48.687 -22.343 6.609   1.00 56.30 ? 771  ASN   A C   1 
ATOM   526  O O   . ASN   A 1 78  ? -48.154 -23.416 6.330   1.00 56.38 ? 771  ASN   A O   1 
ATOM   527  C CB  . ASN   A 1 78  ? -49.660 -21.760 4.384   1.00 58.83 ? 771  ASN   A CB  1 
ATOM   528  C CG  . ASN   A 1 78  ? -51.144 -21.656 4.673   1.00 62.93 ? 771  ASN   A CG  1 
ATOM   529  O OD1 . ASN   A 1 78  ? -51.858 -20.817 4.096   1.00 64.25 ? 771  ASN   A OD1 1 
ATOM   530  N ND2 . ASN   A 1 78  ? -51.646 -22.510 5.567   1.00 63.86 ? 771  ASN   A ND2 1 
ATOM   531  N N   . PRO   A 1 79  ? -49.195 -22.113 7.843   1.00 55.32 ? 772  PRO   A N   1 
ATOM   532  C CA  . PRO   A 1 79  ? -49.881 -20.906 8.346   1.00 54.56 ? 772  PRO   A CA  1 
ATOM   533  C C   . PRO   A 1 79  ? -49.004 -19.666 8.527   1.00 53.78 ? 772  PRO   A C   1 
ATOM   534  O O   . PRO   A 1 79  ? -49.527 -18.579 8.769   1.00 54.09 ? 772  PRO   A O   1 
ATOM   535  C CB  . PRO   A 1 79  ? -50.477 -21.382 9.676   1.00 55.17 ? 772  PRO   A CB  1 
ATOM   536  C CG  . PRO   A 1 79  ? -49.514 -22.426 10.147  1.00 55.76 ? 772  PRO   A CG  1 
ATOM   537  C CD  . PRO   A 1 79  ? -49.111 -23.151 8.892   1.00 54.65 ? 772  PRO   A CD  1 
ATOM   538  N N   . GLY   A 1 80  ? -47.690 -19.837 8.414   1.00 52.52 ? 773  GLY   A N   1 
ATOM   539  C CA  . GLY   A 1 80  ? -46.735 -18.741 8.500   1.00 51.57 ? 773  GLY   A CA  1 
ATOM   540  C C   . GLY   A 1 80  ? -46.203 -18.452 9.885   1.00 49.92 ? 773  GLY   A C   1 
ATOM   541  O O   . GLY   A 1 80  ? -46.593 -19.092 10.855  1.00 50.18 ? 773  GLY   A O   1 
ATOM   542  N N   . ASN   A 1 81  ? -45.315 -17.475 9.983   1.00 48.21 ? 774  ASN   A N   1 
ATOM   543  C CA  . ASN   A 1 81  ? -44.733 -17.065 11.248  1.00 47.04 ? 774  ASN   A CA  1 
ATOM   544  C C   . ASN   A 1 81  ? -44.210 -15.656 11.092  1.00 46.83 ? 774  ASN   A C   1 
ATOM   545  O O   . ASN   A 1 81  ? -43.548 -15.348 10.101  1.00 47.12 ? 774  ASN   A O   1 
ATOM   546  C CB  . ASN   A 1 81  ? -43.604 -17.986 11.650  1.00 46.82 ? 774  ASN   A CB  1 
ATOM   547  C CG  . ASN   A 1 81  ? -43.253 -17.833 13.096  1.00 48.42 ? 774  ASN   A CG  1 
ATOM   548  O OD1 . ASN   A 1 81  ? -43.893 -18.414 13.971  1.00 49.00 ? 774  ASN   A OD1 1 
ATOM   549  N ND2 . ASN   A 1 81  ? -42.250 -17.025 13.382  1.00 48.61 ? 774  ASN   A ND2 1 
ATOM   550  N N   . PRO   A 1 82  ? -44.474 -14.778 12.067  1.00 46.32 ? 775  PRO   A N   1 
ATOM   551  C CA  . PRO   A 1 82  ? -43.998 -13.392 11.949  1.00 45.89 ? 775  PRO   A CA  1 
ATOM   552  C C   . PRO   A 1 82  ? -42.476 -13.228 11.894  1.00 45.22 ? 775  PRO   A C   1 
ATOM   553  O O   . PRO   A 1 82  ? -42.005 -12.176 11.475  1.00 45.39 ? 775  PRO   A O   1 
ATOM   554  C CB  . PRO   A 1 82  ? -44.615 -12.699 13.167  1.00 46.85 ? 775  PRO   A CB  1 
ATOM   555  C CG  . PRO   A 1 82  ? -44.906 -13.802 14.140  1.00 47.49 ? 775  PRO   A CG  1 
ATOM   556  C CD  . PRO   A 1 82  ? -45.264 -14.984 13.296  1.00 46.00 ? 775  PRO   A CD  1 
ATOM   557  N N   . HIS   A 1 83  ? -41.706 -14.265 12.263  1.00 44.14 ? 776  HIS   A N   1 
ATOM   558  C CA  . HIS   A 1 83  ? -40.241 -14.183 12.210  1.00 43.48 ? 776  HIS   A CA  1 
ATOM   559  C C   . HIS   A 1 83  ? -39.617 -15.115 11.140  1.00 42.16 ? 776  HIS   A C   1 
ATOM   560  O O   . HIS   A 1 83  ? -38.445 -15.480 11.228  1.00 41.66 ? 776  HIS   A O   1 
ATOM   561  C CB  . HIS   A 1 83  ? -39.630 -14.407 13.602  1.00 44.16 ? 776  HIS   A CB  1 
ATOM   562  C CG  . HIS   A 1 83  ? -40.316 -13.612 14.666  1.00 46.54 ? 776  HIS   A CG  1 
ATOM   563  N ND1 . HIS   A 1 83  ? -41.268 -14.185 15.491  1.00 48.40 ? 776  HIS   A ND1 1 
ATOM   564  C CD2 . HIS   A 1 83  ? -40.228 -12.293 14.952  1.00 47.77 ? 776  HIS   A CD2 1 
ATOM   565  C CE1 . HIS   A 1 83  ? -41.696 -13.211 16.280  1.00 48.89 ? 776  HIS   A CE1 1 
ATOM   566  N NE2 . HIS   A 1 83  ? -41.097 -12.054 15.997  1.00 48.81 ? 776  HIS   A NE2 1 
ATOM   567  N N   . VAL   A 1 84  ? -40.402 -15.473 10.121  1.00 41.60 ? 777  VAL   A N   1 
ATOM   568  C CA  . VAL   A 1 84  ? -39.945 -16.325 9.029   1.00 41.67 ? 777  VAL   A CA  1 
ATOM   569  C C   . VAL   A 1 84  ? -40.242 -15.629 7.693   1.00 41.40 ? 777  VAL   A C   1 
ATOM   570  O O   . VAL   A 1 84  ? -41.362 -15.173 7.471   1.00 41.53 ? 777  VAL   A O   1 
ATOM   571  C CB  . VAL   A 1 84  ? -40.531 -17.760 9.135   1.00 42.48 ? 777  VAL   A CB  1 
ATOM   572  C CG1 . VAL   A 1 84  ? -40.508 -18.494 7.794   1.00 42.99 ? 777  VAL   A CG1 1 
ATOM   573  C CG2 . VAL   A 1 84  ? -39.804 -18.568 10.209  1.00 42.96 ? 777  VAL   A CG2 1 
ATOM   574  N N   . CYS   A 1 85  ? -39.221 -15.504 6.833   1.00 40.81 ? 778  CYS   A N   1 
ATOM   575  C CA  . CYS   A 1 85  ? -39.348 -14.831 5.548   1.00 40.80 ? 778  CYS   A CA  1 
ATOM   576  C C   . CYS   A 1 85  ? -40.079 -15.663 4.495   1.00 40.82 ? 778  CYS   A C   1 
ATOM   577  O O   . CYS   A 1 85  ? -39.563 -16.685 4.061   1.00 40.77 ? 778  CYS   A O   1 
ATOM   578  C CB  . CYS   A 1 85  ? -37.979 -14.386 5.042   1.00 41.12 ? 778  CYS   A CB  1 
ATOM   579  S SG  . CYS   A 1 85  ? -37.349 -12.882 5.824   1.00 43.36 ? 778  CYS   A SG  1 
ATOM   580  N N   . ARG   A 1 86  ? -41.259 -15.209 4.053   1.00 40.55 ? 779  ARG   A N   1 
ATOM   581  C CA  . ARG   A 1 86  ? -42.002 -15.923 3.014   1.00 40.48 ? 779  ARG   A CA  1 
ATOM   582  C C   . ARG   A 1 86  ? -41.346 -15.667 1.668   1.00 38.88 ? 779  ARG   A C   1 
ATOM   583  O O   . ARG   A 1 86  ? -40.822 -14.581 1.431   1.00 39.12 ? 779  ARG   A O   1 
ATOM   584  C CB  . ARG   A 1 86  ? -43.482 -15.490 2.976   1.00 43.35 ? 779  ARG   A CB  1 
ATOM   585  C CG  . ARG   A 1 86  ? -44.333 -16.040 4.137   1.00 48.99 ? 779  ARG   A CG  1 
ATOM   586  C CD  . ARG   A 1 86  ? -45.644 -15.297 4.414   1.00 54.53 ? 779  ARG   A CD  1 
ATOM   587  N NE  . ARG   A 1 86  ? -46.271 -14.723 3.215   1.00 59.82 ? 779  ARG   A NE  1 
ATOM   588  C CZ  . ARG   A 1 86  ? -46.398 -13.415 2.988   1.00 63.47 ? 779  ARG   A CZ  1 
ATOM   589  N NH1 . ARG   A 1 86  ? -45.956 -12.533 3.879   1.00 63.71 ? 779  ARG   A NH1 1 
ATOM   590  N NH2 . ARG   A 1 86  ? -46.975 -12.981 1.875   1.00 63.74 ? 779  ARG   A NH2 1 
ATOM   591  N N   . LEU   A 1 87  ? -41.340 -16.676 0.807   1.00 37.13 ? 780  LEU   A N   1 
ATOM   592  C CA  . LEU   A 1 87  ? -40.782 -16.558 -0.530  1.00 36.00 ? 780  LEU   A CA  1 
ATOM   593  C C   . LEU   A 1 87  ? -41.948 -16.162 -1.434  1.00 35.27 ? 780  LEU   A C   1 
ATOM   594  O O   . LEU   A 1 87  ? -42.974 -16.839 -1.415  1.00 35.64 ? 780  LEU   A O   1 
ATOM   595  C CB  . LEU   A 1 87  ? -40.219 -17.919 -0.950  1.00 35.58 ? 780  LEU   A CB  1 
ATOM   596  C CG  . LEU   A 1 87  ? -39.524 -17.984 -2.288  1.00 36.04 ? 780  LEU   A CG  1 
ATOM   597  C CD1 . LEU   A 1 87  ? -38.199 -17.285 -2.235  1.00 36.35 ? 780  LEU   A CD1 1 
ATOM   598  C CD2 . LEU   A 1 87  ? -39.305 -19.412 -2.686  1.00 36.44 ? 780  LEU   A CD2 1 
ATOM   599  N N   . LEU   A 1 88  ? -41.840 -15.042 -2.158  1.00 34.14 ? 781  LEU   A N   1 
ATOM   600  C CA  . LEU   A 1 88  ? -42.925 -14.598 -3.036  1.00 33.84 ? 781  LEU   A CA  1 
ATOM   601  C C   . LEU   A 1 88  ? -43.030 -15.454 -4.300  1.00 32.92 ? 781  LEU   A C   1 
ATOM   602  O O   . LEU   A 1 88  ? -44.116 -15.935 -4.626  1.00 33.25 ? 781  LEU   A O   1 
ATOM   603  C CB  . LEU   A 1 88  ? -42.799 -13.109 -3.409  1.00 34.30 ? 781  LEU   A CB  1 
ATOM   604  C CG  . LEU   A 1 88  ? -42.527 -12.128 -2.273  1.00 35.83 ? 781  LEU   A CG  1 
ATOM   605  C CD1 . LEU   A 1 88  ? -42.505 -10.709 -2.805  1.00 36.62 ? 781  LEU   A CD1 1 
ATOM   606  C CD2 . LEU   A 1 88  ? -43.568 -12.238 -1.184  1.00 36.29 ? 781  LEU   A CD2 1 
ATOM   607  N N   . GLY   A 1 89  ? -41.911 -15.655 -4.988  1.00 31.53 ? 782  GLY   A N   1 
ATOM   608  C CA  . GLY   A 1 89  ? -41.903 -16.453 -6.200  1.00 30.76 ? 782  GLY   A CA  1 
ATOM   609  C C   . GLY   A 1 89  ? -40.562 -17.059 -6.539  1.00 29.80 ? 782  GLY   A C   1 
ATOM   610  O O   . GLY   A 1 89  ? -39.593 -16.887 -5.796  1.00 29.55 ? 782  GLY   A O   1 
ATOM   611  N N   . ILE   A 1 90  ? -40.498 -17.762 -7.687  1.00 29.04 ? 783  ILE   A N   1 
ATOM   612  C CA  . ILE   A 1 90  ? -39.281 -18.419 -8.139  1.00 29.00 ? 783  ILE   A CA  1 
ATOM   613  C C   . ILE   A 1 90  ? -39.115 -18.320 -9.652  1.00 29.53 ? 783  ILE   A C   1 
ATOM   614  O O   . ILE   A 1 90  ? -40.100 -18.304 -10.392 1.00 30.29 ? 783  ILE   A O   1 
ATOM   615  C CB  . ILE   A 1 90  ? -39.291 -19.893 -7.664  1.00 29.35 ? 783  ILE   A CB  1 
ATOM   616  C CG1 . ILE   A 1 90  ? -37.901 -20.556 -7.813  1.00 30.19 ? 783  ILE   A CG1 1 
ATOM   617  C CG2 . ILE   A 1 90  ? -40.405 -20.696 -8.345  1.00 29.67 ? 783  ILE   A CG2 1 
ATOM   618  C CD1 . ILE   A 1 90  ? -37.785 -21.989 -7.332  1.00 31.04 ? 783  ILE   A CD1 1 
ATOM   619  N N   . CYS   A 1 91  ? -37.869 -18.248 -10.125 1.00 28.94 ? 784  CYS   A N   1 
ATOM   620  C CA  . CYS   A 1 91  ? -37.600 -18.220 -11.559 1.00 28.64 ? 784  CYS   A CA  1 
ATOM   621  C C   . CYS   A 1 91  ? -36.633 -19.313 -11.930 1.00 28.61 ? 784  CYS   A C   1 
ATOM   622  O O   . CYS   A 1 91  ? -35.419 -19.153 -11.803 1.00 28.47 ? 784  CYS   A O   1 
ATOM   623  C CB  . CYS   A 1 91  ? -37.114 -16.854 -12.031 1.00 28.64 ? 784  CYS   A CB  1 
ATOM   624  S SG  . CYS   A 1 91  ? -36.804 -16.752 -13.813 1.00 28.87 ? 784  CYS   A SG  1 
ATOM   625  N N   . LEU   A 1 92  ? -37.175 -20.432 -12.384 1.00 28.75 ? 785  LEU   A N   1 
ATOM   626  C CA  . LEU   A 1 92  ? -36.360 -21.548 -12.815 1.00 29.31 ? 785  LEU   A CA  1 
ATOM   627  C C   . LEU   A 1 92  ? -36.107 -21.562 -14.325 1.00 29.76 ? 785  LEU   A C   1 
ATOM   628  O O   . LEU   A 1 92  ? -36.864 -22.149 -15.103 1.00 29.84 ? 785  LEU   A O   1 
ATOM   629  C CB  . LEU   A 1 92  ? -36.939 -22.857 -12.323 1.00 29.40 ? 785  LEU   A CB  1 
ATOM   630  C CG  . LEU   A 1 92  ? -36.545 -23.157 -10.916 1.00 30.69 ? 785  LEU   A CG  1 
ATOM   631  C CD1 . LEU   A 1 92  ? -37.458 -24.162 -10.319 1.00 31.31 ? 785  LEU   A CD1 1 
ATOM   632  C CD2 . LEU   A 1 92  ? -35.104 -23.589 -10.847 1.00 31.27 ? 785  LEU   A CD2 1 
ATOM   633  N N   . THR   A 1 93  ? -35.044 -20.863 -14.726 1.00 29.85 ? 786  THR   A N   1 
ATOM   634  C CA  . THR   A 1 93  ? -34.560 -20.792 -16.099 1.00 30.50 ? 786  THR   A CA  1 
ATOM   635  C C   . THR   A 1 93  ? -33.124 -21.405 -16.074 1.00 30.84 ? 786  THR   A C   1 
ATOM   636  O O   . THR   A 1 93  ? -32.966 -22.435 -15.418 1.00 31.58 ? 786  THR   A O   1 
ATOM   637  C CB  . THR   A 1 93  ? -34.756 -19.371 -16.651 1.00 32.22 ? 786  THR   A CB  1 
ATOM   638  O OG1 . THR   A 1 93  ? -34.020 -18.458 -15.829 1.00 33.55 ? 786  THR   A OG1 1 
ATOM   639  C CG2 . THR   A 1 93  ? -36.225 -18.982 -16.748 1.00 32.78 ? 786  THR   A CG2 1 
ATOM   640  N N   . SER   A 1 94  ? -32.094 -20.829 -16.739 1.00 30.33 ? 787  SER   A N   1 
ATOM   641  C CA  . SER   A 1 94  ? -30.746 -21.401 -16.695 1.00 30.55 ? 787  SER   A CA  1 
ATOM   642  C C   . SER   A 1 94  ? -30.166 -21.367 -15.260 1.00 30.85 ? 787  SER   A C   1 
ATOM   643  O O   . SER   A 1 94  ? -29.466 -22.293 -14.846 1.00 31.40 ? 787  SER   A O   1 
ATOM   644  C CB  . SER   A 1 94  ? -29.837 -20.692 -17.694 1.00 31.64 ? 787  SER   A CB  1 
ATOM   645  O OG  . SER   A 1 94  ? -30.332 -20.838 -19.017 1.00 32.80 ? 787  SER   A OG  1 
ATOM   646  N N   . THR   A 1 95  ? -30.534 -20.332 -14.484 1.00 30.12 ? 788  THR   A N   1 
ATOM   647  C CA  . THR   A 1 95  ? -30.138 -20.134 -13.094 1.00 29.55 ? 788  THR   A CA  1 
ATOM   648  C C   . THR   A 1 95  ? -31.386 -20.175 -12.191 1.00 29.74 ? 788  THR   A C   1 
ATOM   649  O O   . THR   A 1 95  ? -32.514 -20.112 -12.689 1.00 29.98 ? 788  THR   A O   1 
ATOM   650  C CB  . THR   A 1 95  ? -29.434 -18.772 -12.956 1.00 29.93 ? 788  THR   A CB  1 
ATOM   651  O OG1 . THR   A 1 95  ? -30.257 -17.747 -13.522 1.00 30.45 ? 788  THR   A OG1 1 
ATOM   652  C CG2 . THR   A 1 95  ? -28.047 -18.762 -13.564 1.00 30.14 ? 788  THR   A CG2 1 
ATOM   653  N N   . VAL   A 1 96  ? -31.192 -20.262 -10.861 1.00 29.39 ? 789  VAL   A N   1 
ATOM   654  C CA  . VAL   A 1 96  ? -32.306 -20.256 -9.913  1.00 29.66 ? 789  VAL   A CA  1 
ATOM   655  C C   . VAL   A 1 96  ? -32.462 -18.859 -9.314  1.00 29.40 ? 789  VAL   A C   1 
ATOM   656  O O   . VAL   A 1 96  ? -31.599 -18.433 -8.544  1.00 29.66 ? 789  VAL   A O   1 
ATOM   657  C CB  . VAL   A 1 96  ? -32.116 -21.301 -8.784  1.00 30.61 ? 789  VAL   A CB  1 
ATOM   658  C CG1 . VAL   A 1 96  ? -33.359 -21.389 -7.903  1.00 30.91 ? 789  VAL   A CG1 1 
ATOM   659  C CG2 . VAL   A 1 96  ? -31.755 -22.668 -9.355  1.00 31.48 ? 789  VAL   A CG2 1 
ATOM   660  N N   . GLN   A 1 97  ? -33.558 -18.159 -9.635  1.00 28.75 ? 790  GLN   A N   1 
ATOM   661  C CA  . GLN   A 1 97  ? -33.782 -16.838 -9.070  1.00 29.04 ? 790  GLN   A CA  1 
ATOM   662  C C   . GLN   A 1 97  ? -34.899 -16.849 -8.018  1.00 30.11 ? 790  GLN   A C   1 
ATOM   663  O O   . GLN   A 1 97  ? -35.941 -17.452 -8.257  1.00 30.57 ? 790  GLN   A O   1 
ATOM   664  C CB  . GLN   A 1 97  ? -33.990 -15.808 -10.166 1.00 29.35 ? 790  GLN   A CB  1 
ATOM   665  C CG  . GLN   A 1 97  ? -32.675 -15.523 -10.872 1.00 30.99 ? 790  GLN   A CG  1 
ATOM   666  C CD  . GLN   A 1 97  ? -32.865 -14.990 -12.268 1.00 32.75 ? 790  GLN   A CD  1 
ATOM   667  O OE1 . GLN   A 1 97  ? -33.270 -13.840 -12.464 1.00 32.78 ? 790  GLN   A OE1 1 
ATOM   668  N NE2 . GLN   A 1 97  ? -32.570 -15.822 -13.264 1.00 32.78 ? 790  GLN   A NE2 1 
ATOM   669  N N   . LEU   A 1 98  ? -34.660 -16.233 -6.832  1.00 29.98 ? 791  LEU   A N   1 
ATOM   670  C CA  . LEU   A 1 98  ? -35.627 -16.245 -5.726  1.00 30.71 ? 791  LEU   A CA  1 
ATOM   671  C C   . LEU   A 1 98  ? -36.134 -14.859 -5.302  1.00 31.84 ? 791  LEU   A C   1 
ATOM   672  O O   . LEU   A 1 98  ? -35.376 -14.033 -4.791  1.00 31.99 ? 791  LEU   A O   1 
ATOM   673  C CB  . LEU   A 1 98  ? -35.044 -16.984 -4.503  1.00 30.37 ? 791  LEU   A CB  1 
ATOM   674  C CG  . LEU   A 1 98  ? -34.677 -18.436 -4.727  1.00 30.72 ? 791  LEU   A CG  1 
ATOM   675  C CD1 . LEU   A 1 98  ? -33.620 -18.890 -3.753  1.00 30.55 ? 791  LEU   A CD1 1 
ATOM   676  C CD2 . LEU   A 1 98  ? -35.887 -19.296 -4.656  1.00 31.28 ? 791  LEU   A CD2 1 
ATOM   677  N N   . ILE   A 1 99  ? -37.440 -14.650 -5.422  1.00 32.24 ? 792  ILE   A N   1 
ATOM   678  C CA  . ILE   A 1 99  ? -38.059 -13.378 -5.078  1.00 32.98 ? 792  ILE   A CA  1 
ATOM   679  C C   . ILE   A 1 99  ? -38.645 -13.377 -3.663  1.00 33.92 ? 792  ILE   A C   1 
ATOM   680  O O   . ILE   A 1 99  ? -39.391 -14.289 -3.335  1.00 34.64 ? 792  ILE   A O   1 
ATOM   681  C CB  . ILE   A 1 99  ? -39.155 -13.075 -6.132  1.00 33.19 ? 792  ILE   A CB  1 
ATOM   682  C CG1 . ILE   A 1 99  ? -38.541 -12.844 -7.534  1.00 34.15 ? 792  ILE   A CG1 1 
ATOM   683  C CG2 . ILE   A 1 99  ? -40.033 -11.894 -5.709  1.00 33.41 ? 792  ILE   A CG2 1 
ATOM   684  C CD1 . ILE   A 1 99  ? -38.256 -14.084 -8.392  1.00 35.27 ? 792  ILE   A CD1 1 
ATOM   685  N N   . THR   A 1 100 ? -38.325 -12.350 -2.836  1.00 33.69 ? 793  THR   A N   1 
ATOM   686  C CA  . THR   A 1 100 ? -38.876 -12.104 -1.483  1.00 33.80 ? 793  THR   A CA  1 
ATOM   687  C C   . THR   A 1 100 ? -39.154 -10.573 -1.331  1.00 33.57 ? 793  THR   A C   1 
ATOM   688  O O   . THR   A 1 100 ? -38.764 -9.800  -2.204  1.00 33.69 ? 793  THR   A O   1 
ATOM   689  C CB  . THR   A 1 100 ? -37.904 -12.573 -0.380  1.00 35.72 ? 793  THR   A CB  1 
ATOM   690  O OG1 . THR   A 1 100 ? -36.625 -12.001 -0.623  1.00 37.20 ? 793  THR   A OG1 1 
ATOM   691  C CG2 . THR   A 1 100 ? -37.805 -14.086 -0.254  1.00 36.33 ? 793  THR   A CG2 1 
ATOM   692  N N   . GLN   A 1 101 ? -39.822 -10.123 -0.245  1.00 33.21 ? 794  GLN   A N   1 
ATOM   693  C CA  . GLN   A 1 101 ? -40.074 -8.685  -0.035  1.00 33.20 ? 794  GLN   A CA  1 
ATOM   694  C C   . GLN   A 1 101 ? -38.754 -7.939  0.172   1.00 32.07 ? 794  GLN   A C   1 
ATOM   695  O O   . GLN   A 1 101 ? -37.838 -8.471  0.808   1.00 32.08 ? 794  GLN   A O   1 
ATOM   696  C CB  . GLN   A 1 101 ? -40.984 -8.445  1.196   1.00 35.70 ? 794  GLN   A CB  1 
ATOM   697  C CG  . GLN   A 1 101 ? -42.253 -7.631  0.909   1.00 40.50 ? 794  GLN   A CG  1 
ATOM   698  C CD  . GLN   A 1 101 ? -41.995 -6.165  0.617   1.00 45.52 ? 794  GLN   A CD  1 
ATOM   699  O OE1 . GLN   A 1 101 ? -41.301 -5.471  1.372   1.00 47.01 ? 794  GLN   A OE1 1 
ATOM   700  N NE2 . GLN   A 1 101 ? -42.538 -5.662  -0.496  1.00 45.67 ? 794  GLN   A NE2 1 
ATOM   701  N N   . LEU   A 1 102 ? -38.650 -6.718  -0.369  1.00 30.97 ? 795  LEU   A N   1 
ATOM   702  C CA  . LEU   A 1 102 ? -37.453 -5.924  -0.185  1.00 30.42 ? 795  LEU   A CA  1 
ATOM   703  C C   . LEU   A 1 102 ? -37.470 -5.307  1.189   1.00 30.97 ? 795  LEU   A C   1 
ATOM   704  O O   . LEU   A 1 102 ? -38.279 -4.421  1.451   1.00 31.31 ? 795  LEU   A O   1 
ATOM   705  C CB  . LEU   A 1 102 ? -37.309 -4.844  -1.251  1.00 29.71 ? 795  LEU   A CB  1 
ATOM   706  C CG  . LEU   A 1 102 ? -36.092 -3.941  -1.105  1.00 30.04 ? 795  LEU   A CG  1 
ATOM   707  C CD1 . LEU   A 1 102 ? -34.792 -4.729  -1.078  1.00 30.14 ? 795  LEU   A CD1 1 
ATOM   708  C CD2 . LEU   A 1 102 ? -36.058 -2.923  -2.200  1.00 30.53 ? 795  LEU   A CD2 1 
ATOM   709  N N   . MET   A 1 103 ? -36.595 -5.802  2.078   1.00 30.77 ? 796  MET   A N   1 
ATOM   710  C CA  . MET   A 1 103 ? -36.447 -5.271  3.424   1.00 31.04 ? 796  MET   A CA  1 
ATOM   711  C C   . MET   A 1 103 ? -35.348 -4.233  3.313   1.00 30.44 ? 796  MET   A C   1 
ATOM   712  O O   . MET   A 1 103 ? -34.190 -4.578  3.068   1.00 30.50 ? 796  MET   A O   1 
ATOM   713  C CB  . MET   A 1 103 ? -36.029 -6.369  4.418   1.00 32.43 ? 796  MET   A CB  1 
ATOM   714  C CG  . MET   A 1 103 ? -36.731 -7.702  4.196   1.00 36.05 ? 796  MET   A CG  1 
ATOM   715  S SD  . MET   A 1 103 ? -37.644 -8.298  5.646   1.00 43.34 ? 796  MET   A SD  1 
ATOM   716  C CE  . MET   A 1 103 ? -38.838 -6.982  5.834   1.00 42.96 ? 796  MET   A CE  1 
ATOM   717  N N   . PRO   A 1 104 ? -35.698 -2.944  3.424   1.00 29.66 ? 797  PRO   A N   1 
ATOM   718  C CA  . PRO   A 1 104 ? -34.683 -1.898  3.263   1.00 29.40 ? 797  PRO   A CA  1 
ATOM   719  C C   . PRO   A 1 104 ? -33.665 -1.788  4.392   1.00 29.67 ? 797  PRO   A C   1 
ATOM   720  O O   . PRO   A 1 104 ? -32.659 -1.106  4.215   1.00 29.61 ? 797  PRO   A O   1 
ATOM   721  C CB  . PRO   A 1 104 ? -35.512 -0.612  3.150   1.00 29.82 ? 797  PRO   A CB  1 
ATOM   722  C CG  . PRO   A 1 104 ? -36.934 -1.050  2.984   1.00 30.15 ? 797  PRO   A CG  1 
ATOM   723  C CD  . PRO   A 1 104 ? -37.033 -2.369  3.650   1.00 28.82 ? 797  PRO   A CD  1 
ATOM   724  N N   . PHE   A 1 105 ? -33.897 -2.456  5.535   1.00 29.80 ? 798  PHE   A N   1 
ATOM   725  C CA  . PHE   A 1 105 ? -32.993 -2.319  6.678   1.00 30.52 ? 798  PHE   A CA  1 
ATOM   726  C C   . PHE   A 1 105 ? -32.003 -3.479  6.863   1.00 30.16 ? 798  PHE   A C   1 
ATOM   727  O O   . PHE   A 1 105 ? -31.394 -3.605  7.926   1.00 30.27 ? 798  PHE   A O   1 
ATOM   728  C CB  . PHE   A 1 105 ? -33.790 -2.047  7.966   1.00 31.27 ? 798  PHE   A CB  1 
ATOM   729  C CG  . PHE   A 1 105 ? -34.670 -0.834  7.771   1.00 32.72 ? 798  PHE   A CG  1 
ATOM   730  C CD1 . PHE   A 1 105 ? -34.114 0.419   7.574   1.00 33.78 ? 798  PHE   A CD1 1 
ATOM   731  C CD2 . PHE   A 1 105 ? -36.037 -0.971  7.617   1.00 33.81 ? 798  PHE   A CD2 1 
ATOM   732  C CE1 . PHE   A 1 105 ? -34.917 1.519   7.300   1.00 34.55 ? 798  PHE   A CE1 1 
ATOM   733  C CE2 . PHE   A 1 105 ? -36.835 0.130   7.342   1.00 34.57 ? 798  PHE   A CE2 1 
ATOM   734  C CZ  . PHE   A 1 105 ? -36.271 1.367   7.185   1.00 34.36 ? 798  PHE   A CZ  1 
ATOM   735  N N   . GLY   A 1 106 ? -31.805 -4.266  5.814   1.00 29.61 ? 799  GLY   A N   1 
ATOM   736  C CA  . GLY   A 1 106 ? -30.842 -5.359  5.792   1.00 29.70 ? 799  GLY   A CA  1 
ATOM   737  C C   . GLY   A 1 106 ? -30.808 -6.317  6.969   1.00 29.57 ? 799  GLY   A C   1 
ATOM   738  O O   . GLY   A 1 106 ? -31.743 -6.402  7.764   1.00 29.44 ? 799  GLY   A O   1 
ATOM   739  N N   . CYS   A 1 107 ? -29.700 -7.043  7.074   1.00 29.31 ? 800  CYS   A N   1 
ATOM   740  C CA  . CYS   A 1 107 ? -29.474 -8.068  8.071   1.00 29.51 ? 800  CYS   A CA  1 
ATOM   741  C C   . CYS   A 1 107 ? -29.121 -7.517  9.440   1.00 29.83 ? 800  CYS   A C   1 
ATOM   742  O O   . CYS   A 1 107 ? -28.692 -6.373  9.574   1.00 30.15 ? 800  CYS   A O   1 
ATOM   743  C CB  . CYS   A 1 107 ? -28.444 -9.090  7.585   1.00 29.97 ? 800  CYS   A CB  1 
ATOM   744  S SG  . CYS   A 1 107 ? -26.856 -8.390  7.049   1.00 31.89 ? 800  CYS   A SG  1 
ATOM   745  N N   . LEU   A 1 108 ? -29.340 -8.333  10.464  1.00 29.68 ? 801  LEU   A N   1 
ATOM   746  C CA  . LEU   A 1 108 ? -29.029 -7.988  11.840  1.00 30.25 ? 801  LEU   A CA  1 
ATOM   747  C C   . LEU   A 1 108 ? -27.502 -7.950  12.065  1.00 31.06 ? 801  LEU   A C   1 
ATOM   748  O O   . LEU   A 1 108 ? -27.052 -7.211  12.931  1.00 31.13 ? 801  LEU   A O   1 
ATOM   749  C CB  . LEU   A 1 108 ? -29.729 -8.976  12.787  1.00 30.21 ? 801  LEU   A CB  1 
ATOM   750  C CG  . LEU   A 1 108 ? -29.774 -8.643  14.277  1.00 31.12 ? 801  LEU   A CG  1 
ATOM   751  C CD1 . LEU   A 1 108 ? -30.361 -7.274  14.524  1.00 31.63 ? 801  LEU   A CD1 1 
ATOM   752  C CD2 . LEU   A 1 108 ? -30.578 -9.681  15.031  1.00 31.61 ? 801  LEU   A CD2 1 
ATOM   753  N N   . LEU   A 1 109 ? -26.704 -8.660  11.230  1.00 31.50 ? 802  LEU   A N   1 
ATOM   754  C CA  . LEU   A 1 109 ? -25.243 -8.650  11.304  1.00 32.14 ? 802  LEU   A CA  1 
ATOM   755  C C   . LEU   A 1 109 ? -24.727 -7.232  11.095  1.00 32.48 ? 802  LEU   A C   1 
ATOM   756  O O   . LEU   A 1 109 ? -23.854 -6.787  11.834  1.00 32.60 ? 802  LEU   A O   1 
ATOM   757  C CB  . LEU   A 1 109 ? -24.648 -9.579  10.238  1.00 32.43 ? 802  LEU   A CB  1 
ATOM   758  C CG  . LEU   A 1 109 ? -23.129 -9.641  10.219  1.00 34.26 ? 802  LEU   A CG  1 
ATOM   759  C CD1 . LEU   A 1 109 ? -22.596 -10.232 11.497  1.00 34.78 ? 802  LEU   A CD1 1 
ATOM   760  C CD2 . LEU   A 1 109 ? -22.630 -10.435 9.031   1.00 35.25 ? 802  LEU   A CD2 1 
ATOM   761  N N   . ASP   A 1 110 ? -25.294 -6.516  10.101  1.00 32.27 ? 803  ASP   A N   1 
ATOM   762  C CA  . ASP   A 1 110 ? -24.956 -5.129  9.799   1.00 32.38 ? 803  ASP   A CA  1 
ATOM   763  C C   . ASP   A 1 110 ? -25.515 -4.240  10.890  1.00 32.56 ? 803  ASP   A C   1 
ATOM   764  O O   . ASP   A 1 110 ? -24.809 -3.368  11.375  1.00 33.07 ? 803  ASP   A O   1 
ATOM   765  C CB  . ASP   A 1 110 ? -25.576 -4.699  8.462   1.00 33.95 ? 803  ASP   A CB  1 
ATOM   766  C CG  . ASP   A 1 110 ? -25.063 -5.423  7.242   1.00 37.40 ? 803  ASP   A CG  1 
ATOM   767  O OD1 . ASP   A 1 110 ? -24.285 -6.391  7.407   1.00 37.41 ? 803  ASP   A OD1 1 
ATOM   768  O OD2 . ASP   A 1 110 ? -25.429 -5.013  6.118   1.00 39.74 ? 803  ASP   A OD2 1 
ATOM   769  N N   . TYR   A 1 111 ? -26.773 -4.467  11.298  1.00 31.98 ? 804  TYR   A N   1 
ATOM   770  C CA  . TYR   A 1 111 ? -27.418 -3.661  12.322  1.00 31.89 ? 804  TYR   A CA  1 
ATOM   771  C C   . TYR   A 1 111 ? -26.635 -3.604  13.628  1.00 32.36 ? 804  TYR   A C   1 
ATOM   772  O O   . TYR   A 1 111 ? -26.523 -2.530  14.209  1.00 32.80 ? 804  TYR   A O   1 
ATOM   773  C CB  . TYR   A 1 111 ? -28.862 -4.110  12.551  1.00 31.61 ? 804  TYR   A CB  1 
ATOM   774  C CG  . TYR   A 1 111 ? -29.677 -3.064  13.275  1.00 32.30 ? 804  TYR   A CG  1 
ATOM   775  C CD1 . TYR   A 1 111 ? -30.283 -2.026  12.583  1.00 33.05 ? 804  TYR   A CD1 1 
ATOM   776  C CD2 . TYR   A 1 111 ? -29.818 -3.095  14.660  1.00 33.06 ? 804  TYR   A CD2 1 
ATOM   777  C CE1 . TYR   A 1 111 ? -31.012 -1.046  13.246  1.00 34.01 ? 804  TYR   A CE1 1 
ATOM   778  C CE2 . TYR   A 1 111 ? -30.539 -2.117  15.334  1.00 33.86 ? 804  TYR   A CE2 1 
ATOM   779  C CZ  . TYR   A 1 111 ? -31.141 -1.096  14.622  1.00 34.80 ? 804  TYR   A CZ  1 
ATOM   780  O OH  . TYR   A 1 111 ? -31.858 -0.124  15.274  1.00 36.09 ? 804  TYR   A OH  1 
ATOM   781  N N   . VAL   A 1 112 ? -26.075 -4.733  14.086  1.00 32.13 ? 805  VAL   A N   1 
ATOM   782  C CA  . VAL   A 1 112 ? -25.297 -4.738  15.324  1.00 32.18 ? 805  VAL   A CA  1 
ATOM   783  C C   . VAL   A 1 112 ? -23.901 -4.112  15.130  1.00 32.28 ? 805  VAL   A C   1 
ATOM   784  O O   . VAL   A 1 112 ? -23.405 -3.439  16.031  1.00 32.15 ? 805  VAL   A O   1 
ATOM   785  C CB  . VAL   A 1 112 ? -25.235 -6.128  15.988  1.00 32.81 ? 805  VAL   A CB  1 
ATOM   786  C CG1 . VAL   A 1 112 ? -26.629 -6.613  16.361  1.00 33.39 ? 805  VAL   A CG1 1 
ATOM   787  C CG2 . VAL   A 1 112 ? -24.538 -7.136  15.093  1.00 33.28 ? 805  VAL   A CG2 1 
ATOM   788  N N   . ARG   A 1 113 ? -23.292 -4.289  13.945  1.00 32.29 ? 806  ARG   A N   1 
ATOM   789  C CA  . ARG   A 1 113 ? -21.975 -3.725  13.666  1.00 32.49 ? 806  ARG   A CA  1 
ATOM   790  C C   . ARG   A 1 113 ? -22.030 -2.217  13.532  1.00 32.96 ? 806  ARG   A C   1 
ATOM   791  O O   . ARG   A 1 113 ? -21.144 -1.528  14.024  1.00 33.48 ? 806  ARG   A O   1 
ATOM   792  C CB  . ARG   A 1 113 ? -21.351 -4.349  12.406  1.00 32.93 ? 806  ARG   A CB  1 
ATOM   793  C CG  . ARG   A 1 113 ? -20.945 -5.798  12.601  1.00 34.43 ? 806  ARG   A CG  1 
ATOM   794  C CD  . ARG   A 1 113 ? -19.836 -6.229  11.673  1.00 36.14 ? 806  ARG   A CD  1 
ATOM   795  N NE  . ARG   A 1 113 ? -20.018 -7.611  11.228  1.00 37.93 ? 806  ARG   A NE  1 
ATOM   796  C CZ  . ARG   A 1 113 ? -19.085 -8.331  10.614  1.00 39.81 ? 806  ARG   A CZ  1 
ATOM   797  N NH1 . ARG   A 1 113 ? -17.881 -7.820  10.392  1.00 39.54 ? 806  ARG   A NH1 1 
ATOM   798  N NH2 . ARG   A 1 113 ? -19.336 -9.580  10.249  1.00 39.86 ? 806  ARG   A NH2 1 
ATOM   799  N N   . GLU   A 1 114 ? -23.075 -1.703  12.902  1.00 32.79 ? 807  GLU   A N   1 
ATOM   800  C CA  . GLU   A 1 114 ? -23.225 -0.273  12.701  1.00 33.66 ? 807  GLU   A CA  1 
ATOM   801  C C   . GLU   A 1 114 ? -23.744 0.440   13.938  1.00 34.00 ? 807  GLU   A C   1 
ATOM   802  O O   . GLU   A 1 114 ? -23.369 1.582   14.180  1.00 34.23 ? 807  GLU   A O   1 
ATOM   803  C CB  . GLU   A 1 114 ? -24.177 -0.001  11.518  1.00 36.76 ? 807  GLU   A CB  1 
ATOM   804  C CG  . GLU   A 1 114 ? -23.660 -0.455  10.160  1.00 41.69 ? 807  GLU   A CG  1 
ATOM   805  C CD  . GLU   A 1 114 ? -24.751 -0.694  9.135   1.00 47.33 ? 807  GLU   A CD  1 
ATOM   806  O OE1 . GLU   A 1 114 ? -25.893 -1.005  9.546   1.00 47.32 ? 807  GLU   A OE1 1 
ATOM   807  O OE2 . GLU   A 1 114 ? -24.464 -0.575  7.921   1.00 50.42 ? 807  GLU   A OE2 1 
ATOM   808  N N   . HIS   A 1 115 ? -24.613 -0.213  14.710  1.00 33.94 ? 808  HIS   A N   1 
ATOM   809  C CA  . HIS   A 1 115 ? -25.246 0.421   15.854  1.00 34.67 ? 808  HIS   A CA  1 
ATOM   810  C C   . HIS   A 1 115 ? -24.633 0.103   17.229  1.00 35.85 ? 808  HIS   A C   1 
ATOM   811  O O   . HIS   A 1 115 ? -25.120 0.633   18.225  1.00 35.85 ? 808  HIS   A O   1 
ATOM   812  C CB  . HIS   A 1 115 ? -26.738 0.079   15.859  1.00 35.06 ? 808  HIS   A CB  1 
ATOM   813  C CG  . HIS   A 1 115 ? -27.468 0.518   14.632  1.00 36.80 ? 808  HIS   A CG  1 
ATOM   814  N ND1 . HIS   A 1 115 ? -27.133 0.039   13.380  1.00 38.68 ? 808  HIS   A ND1 1 
ATOM   815  C CD2 . HIS   A 1 115 ? -28.517 1.362   14.508  1.00 37.85 ? 808  HIS   A CD2 1 
ATOM   816  C CE1 . HIS   A 1 115 ? -27.969 0.619   12.535  1.00 39.02 ? 808  HIS   A CE1 1 
ATOM   817  N NE2 . HIS   A 1 115 ? -28.825 1.417   13.169  1.00 38.88 ? 808  HIS   A NE2 1 
ATOM   818  N N   . LYS   A 1 116 ? -23.595 -0.761  17.277  1.00 36.45 ? 809  LYS   A N   1 
ATOM   819  C CA  . LYS   A 1 116 ? -22.837 -1.250  18.452  1.00 37.09 ? 809  LYS   A CA  1 
ATOM   820  C C   . LYS   A 1 116 ? -23.040 -0.470  19.781  1.00 37.99 ? 809  LYS   A C   1 
ATOM   821  O O   . LYS   A 1 116 ? -23.441 -1.071  20.772  1.00 38.00 ? 809  LYS   A O   1 
ATOM   822  C CB  . LYS   A 1 116 ? -21.332 -1.329  18.102  1.00 38.35 ? 809  LYS   A CB  1 
ATOM   823  C CG  . LYS   A 1 116 ? -20.421 -1.749  19.240  1.00 41.47 ? 809  LYS   A CG  1 
ATOM   824  C CD  . LYS   A 1 116 ? -19.453 -0.643  19.642  1.00 45.05 ? 809  LYS   A CD  1 
ATOM   825  C CE  . LYS   A 1 116 ? -19.492 -0.364  21.133  1.00 47.52 ? 809  LYS   A CE  1 
ATOM   826  N NZ  . LYS   A 1 116 ? -18.975 -1.503  21.937  1.00 48.56 ? 809  LYS   A NZ  1 
ATOM   827  N N   . ASP   A 1 117 ? -22.744 0.837   19.810  1.00 38.79 ? 810  ASP   A N   1 
ATOM   828  C CA  . ASP   A 1 117 ? -22.842 1.643   21.028  1.00 40.18 ? 810  ASP   A CA  1 
ATOM   829  C C   . ASP   A 1 117 ? -24.288 1.906   21.460  1.00 41.03 ? 810  ASP   A C   1 
ATOM   830  O O   . ASP   A 1 117 ? -24.645 1.720   22.627  1.00 41.38 ? 810  ASP   A O   1 
ATOM   831  C CB  . ASP   A 1 117 ? -22.093 2.986   20.856  1.00 42.35 ? 810  ASP   A CB  1 
ATOM   832  C CG  . ASP   A 1 117 ? -20.765 2.896   20.121  1.00 48.10 ? 810  ASP   A CG  1 
ATOM   833  O OD1 . ASP   A 1 117 ? -20.783 2.670   18.886  1.00 49.39 ? 810  ASP   A OD1 1 
ATOM   834  O OD2 . ASP   A 1 117 ? -19.710 3.071   20.775  1.00 50.34 ? 810  ASP   A OD2 1 
ATOM   835  N N   . ASN   A 1 118 ? -25.109 2.314   20.496  1.00 41.12 ? 811  ASN   A N   1 
ATOM   836  C CA  . ASN   A 1 118 ? -26.505 2.715   20.619  1.00 41.84 ? 811  ASN   A CA  1 
ATOM   837  C C   . ASN   A 1 118 ? -27.482 1.562   20.913  1.00 41.90 ? 811  ASN   A C   1 
ATOM   838  O O   . ASN   A 1 118 ? -28.630 1.816   21.267  1.00 41.90 ? 811  ASN   A O   1 
ATOM   839  C CB  . ASN   A 1 118 ? -26.935 3.459   19.348  1.00 43.77 ? 811  ASN   A CB  1 
ATOM   840  C CG  . ASN   A 1 118 ? -25.825 4.225   18.634  1.00 48.26 ? 811  ASN   A CG  1 
ATOM   841  O OD1 . ASN   A 1 118 ? -25.658 4.153   17.398  1.00 49.31 ? 811  ASN   A OD1 1 
ATOM   842  N ND2 . ASN   A 1 118 ? -25.032 4.963   19.406  1.00 49.50 ? 811  ASN   A ND2 1 
ATOM   843  N N   . ILE   A 1 119 ? -27.043 0.307   20.762  1.00 41.83 ? 812  ILE   A N   1 
ATOM   844  C CA  . ILE   A 1 119 ? -27.899 -0.853  21.021  1.00 42.30 ? 812  ILE   A CA  1 
ATOM   845  C C   . ILE   A 1 119 ? -28.038 -1.135  22.531  1.00 42.67 ? 812  ILE   A C   1 
ATOM   846  O O   . ILE   A 1 119 ? -27.058 -1.041  23.279  1.00 42.92 ? 812  ILE   A O   1 
ATOM   847  C CB  . ILE   A 1 119 ? -27.411 -2.081  20.196  1.00 42.84 ? 812  ILE   A CB  1 
ATOM   848  C CG1 . ILE   A 1 119 ? -27.957 -1.984  18.764  1.00 44.28 ? 812  ILE   A CG1 1 
ATOM   849  C CG2 . ILE   A 1 119 ? -27.787 -3.429  20.826  1.00 43.10 ? 812  ILE   A CG2 1 
ATOM   850  C CD1 . ILE   A 1 119 ? -27.421 -2.989  17.802  1.00 45.79 ? 812  ILE   A CD1 1 
ATOM   851  N N   . GLY   A 1 120 ? -29.259 -1.464  22.956  1.00 42.33 ? 813  GLY   A N   1 
ATOM   852  C CA  . GLY   A 1 120 ? -29.551 -1.758  24.354  1.00 42.38 ? 813  GLY   A CA  1 
ATOM   853  C C   . GLY   A 1 120 ? -29.562 -3.238  24.683  1.00 42.06 ? 813  GLY   A C   1 
ATOM   854  O O   . GLY   A 1 120 ? -29.313 -4.076  23.813  1.00 42.56 ? 813  GLY   A O   1 
ATOM   855  N N   . SER   A 1 121 ? -29.868 -3.574  25.938  1.00 41.09 ? 814  SER   A N   1 
ATOM   856  C CA  . SER   A 1 121 ? -29.896 -4.968  26.370  1.00 40.67 ? 814  SER   A CA  1 
ATOM   857  C C   . SER   A 1 121 ? -31.225 -5.636  26.066  1.00 39.70 ? 814  SER   A C   1 
ATOM   858  O O   . SER   A 1 121 ? -31.240 -6.826  25.765  1.00 39.79 ? 814  SER   A O   1 
ATOM   859  C CB  . SER   A 1 121 ? -29.557 -5.087  27.854  1.00 42.11 ? 814  SER   A CB  1 
ATOM   860  O OG  . SER   A 1 121 ? -30.423 -4.298  28.651  1.00 44.63 ? 814  SER   A OG  1 
ATOM   861  N N   . GLN   A 1 122 ? -32.338 -4.882  26.139  1.00 38.74 ? 815  GLN   A N   1 
ATOM   862  C CA  . GLN   A 1 122 ? -33.673 -5.408  25.821  1.00 38.53 ? 815  GLN   A CA  1 
ATOM   863  C C   . GLN   A 1 122 ? -33.710 -5.884  24.362  1.00 38.38 ? 815  GLN   A C   1 
ATOM   864  O O   . GLN   A 1 122 ? -34.266 -6.934  24.065  1.00 38.38 ? 815  GLN   A O   1 
ATOM   865  C CB  . GLN   A 1 122 ? -34.744 -4.326  26.053  1.00 39.81 ? 815  GLN   A CB  1 
ATOM   866  C CG  . GLN   A 1 122 ? -36.165 -4.738  25.661  1.00 42.89 ? 815  GLN   A CG  1 
ATOM   867  C CD  . GLN   A 1 122 ? -36.893 -5.525  26.729  1.00 47.65 ? 815  GLN   A CD  1 
ATOM   868  O OE1 . GLN   A 1 122 ? -36.704 -5.325  27.937  1.00 49.61 ? 815  GLN   A OE1 1 
ATOM   869  N NE2 . GLN   A 1 122 ? -37.768 -6.425  26.309  1.00 48.10 ? 815  GLN   A NE2 1 
ATOM   870  N N   . TYR   A 1 123 ? -33.067 -5.119  23.472  1.00 37.98 ? 816  TYR   A N   1 
ATOM   871  C CA  . TYR   A 1 123 ? -32.941 -5.370  22.048  1.00 37.92 ? 816  TYR   A CA  1 
ATOM   872  C C   . TYR   A 1 123 ? -32.319 -6.732  21.739  1.00 36.66 ? 816  TYR   A C   1 
ATOM   873  O O   . TYR   A 1 123 ? -32.916 -7.508  21.013  1.00 36.77 ? 816  TYR   A O   1 
ATOM   874  C CB  . TYR   A 1 123 ? -32.102 -4.248  21.419  1.00 38.66 ? 816  TYR   A CB  1 
ATOM   875  C CG  . TYR   A 1 123 ? -32.893 -3.031  20.998  1.00 40.14 ? 816  TYR   A CG  1 
ATOM   876  C CD1 . TYR   A 1 123 ? -33.761 -3.085  19.917  1.00 41.35 ? 816  TYR   A CD1 1 
ATOM   877  C CD2 . TYR   A 1 123 ? -32.701 -1.803  21.618  1.00 41.23 ? 816  TYR   A CD2 1 
ATOM   878  C CE1 . TYR   A 1 123 ? -34.446 -1.958  19.483  1.00 42.49 ? 816  TYR   A CE1 1 
ATOM   879  C CE2 . TYR   A 1 123 ? -33.383 -0.669  21.195  1.00 42.39 ? 816  TYR   A CE2 1 
ATOM   880  C CZ  . TYR   A 1 123 ? -34.257 -0.752  20.124  1.00 43.63 ? 816  TYR   A CZ  1 
ATOM   881  O OH  . TYR   A 1 123 ? -34.941 0.350   19.673  1.00 45.65 ? 816  TYR   A OH  1 
ATOM   882  N N   . LEU   A 1 124 ? -31.140 -7.026  22.289  1.00 35.49 ? 817  LEU   A N   1 
ATOM   883  C CA  . LEU   A 1 124 ? -30.436 -8.281  22.043  1.00 35.10 ? 817  LEU   A CA  1 
ATOM   884  C C   . LEU   A 1 124 ? -31.204 -9.499  22.551  1.00 34.40 ? 817  LEU   A C   1 
ATOM   885  O O   . LEU   A 1 124 ? -31.301 -10.504 21.851  1.00 33.87 ? 817  LEU   A O   1 
ATOM   886  C CB  . LEU   A 1 124 ? -29.046 -8.218  22.681  1.00 35.47 ? 817  LEU   A CB  1 
ATOM   887  C CG  . LEU   A 1 124 ? -28.176 -7.079  22.182  1.00 37.12 ? 817  LEU   A CG  1 
ATOM   888  C CD1 . LEU   A 1 124 ? -27.089 -6.736  23.180  1.00 37.54 ? 817  LEU   A CD1 1 
ATOM   889  C CD2 . LEU   A 1 124 ? -27.609 -7.397  20.813  1.00 37.95 ? 817  LEU   A CD2 1 
ATOM   890  N N   . LEU   A 1 125 ? -31.758 -9.409  23.768  1.00 34.21 ? 818  LEU   A N   1 
ATOM   891  C CA  . LEU   A 1 125 ? -32.533 -10.503 24.343  1.00 34.01 ? 818  LEU   A CA  1 
ATOM   892  C C   . LEU   A 1 125 ? -33.844 -10.709 23.572  1.00 33.86 ? 818  LEU   A C   1 
ATOM   893  O O   . LEU   A 1 125 ? -34.250 -11.848 23.364  1.00 34.12 ? 818  LEU   A O   1 
ATOM   894  C CB  . LEU   A 1 125 ? -32.796 -10.255 25.825  1.00 34.00 ? 818  LEU   A CB  1 
ATOM   895  C CG  . LEU   A 1 125 ? -31.548 -10.185 26.700  1.00 35.52 ? 818  LEU   A CG  1 
ATOM   896  C CD1 . LEU   A 1 125 ? -31.900 -9.850  28.123  1.00 35.78 ? 818  LEU   A CD1 1 
ATOM   897  C CD2 . LEU   A 1 125 ? -30.772 -11.489 26.668  1.00 36.36 ? 818  LEU   A CD2 1 
ATOM   898  N N   . ASN   A 1 126 ? -34.462 -9.619  23.087  1.00 33.00 ? 819  ASN   A N   1 
ATOM   899  C CA  . ASN   A 1 126 ? -35.682 -9.687  22.296  1.00 32.57 ? 819  ASN   A CA  1 
ATOM   900  C C   . ASN   A 1 126 ? -35.363 -10.380 20.976  1.00 32.10 ? 819  ASN   A C   1 
ATOM   901  O O   . ASN   A 1 126 ? -36.095 -11.277 20.566  1.00 32.25 ? 819  ASN   A O   1 
ATOM   902  C CB  . ASN   A 1 126 ? -36.211 -8.277  22.018  1.00 33.77 ? 819  ASN   A CB  1 
ATOM   903  C CG  . ASN   A 1 126 ? -37.290 -7.768  22.936  1.00 37.11 ? 819  ASN   A CG  1 
ATOM   904  O OD1 . ASN   A 1 126 ? -37.980 -6.793  22.616  1.00 38.28 ? 819  ASN   A OD1 1 
ATOM   905  N ND2 . ASN   A 1 126 ? -37.460 -8.390  24.094  1.00 38.06 ? 819  ASN   A ND2 1 
ATOM   906  N N   . TRP   A 1 127 ? -34.244 -9.990  20.332  1.00 31.25 ? 820  TRP   A N   1 
ATOM   907  C CA  . TRP   A 1 127 ? -33.778 -10.575 19.083  1.00 30.65 ? 820  TRP   A CA  1 
ATOM   908  C C   . TRP   A 1 127 ? -33.506 -12.063 19.275  1.00 30.51 ? 820  TRP   A C   1 
ATOM   909  O O   . TRP   A 1 127 ? -33.887 -12.858 18.427  1.00 30.70 ? 820  TRP   A O   1 
ATOM   910  C CB  . TRP   A 1 127 ? -32.528 -9.838  18.570  1.00 30.35 ? 820  TRP   A CB  1 
ATOM   911  C CG  . TRP   A 1 127 ? -32.788 -8.425  18.115  1.00 30.96 ? 820  TRP   A CG  1 
ATOM   912  C CD1 . TRP   A 1 127 ? -33.944 -7.931  17.576  1.00 31.78 ? 820  TRP   A CD1 1 
ATOM   913  C CD2 . TRP   A 1 127 ? -31.837 -7.348  18.076  1.00 31.11 ? 820  TRP   A CD2 1 
ATOM   914  N NE1 . TRP   A 1 127 ? -33.785 -6.604  17.249  1.00 31.94 ? 820  TRP   A NE1 1 
ATOM   915  C CE2 . TRP   A 1 127 ? -32.496 -6.226  17.531  1.00 31.75 ? 820  TRP   A CE2 1 
ATOM   916  C CE3 . TRP   A 1 127 ? -30.498 -7.217  18.469  1.00 31.64 ? 820  TRP   A CE3 1 
ATOM   917  C CZ2 . TRP   A 1 127 ? -31.860 -4.995  17.370  1.00 32.35 ? 820  TRP   A CZ2 1 
ATOM   918  C CZ3 . TRP   A 1 127 ? -29.877 -5.992  18.320  1.00 32.32 ? 820  TRP   A CZ3 1 
ATOM   919  C CH2 . TRP   A 1 127 ? -30.556 -4.899  17.782  1.00 32.42 ? 820  TRP   A CH2 1 
ATOM   920  N N   . CYS   A 1 128 ? -32.941 -12.453 20.430  1.00 30.02 ? 821  CYS   A N   1 
ATOM   921  C CA  . CYS   A 1 128 ? -32.675 -13.851 20.737  1.00 29.72 ? 821  CYS   A CA  1 
ATOM   922  C C   . CYS   A 1 128 ? -33.943 -14.652 20.948  1.00 30.20 ? 821  CYS   A C   1 
ATOM   923  O O   . CYS   A 1 128 ? -33.937 -15.848 20.678  1.00 30.47 ? 821  CYS   A O   1 
ATOM   924  C CB  . CYS   A 1 128 ? -31.726 -13.977 21.917  1.00 29.25 ? 821  CYS   A CB  1 
ATOM   925  S SG  . CYS   A 1 128 ? -30.154 -13.125 21.673  1.00 29.37 ? 821  CYS   A SG  1 
ATOM   926  N N   . VAL   A 1 129 ? -35.025 -14.020 21.423  1.00 30.17 ? 822  VAL   A N   1 
ATOM   927  C CA  . VAL   A 1 129 ? -36.305 -14.709 21.553  1.00 30.73 ? 822  VAL   A CA  1 
ATOM   928  C C   . VAL   A 1 129 ? -36.897 -14.859 20.148  1.00 31.41 ? 822  VAL   A C   1 
ATOM   929  O O   . VAL   A 1 129 ? -37.389 -15.932 19.809  1.00 32.15 ? 822  VAL   A O   1 
ATOM   930  C CB  . VAL   A 1 129 ? -37.310 -13.965 22.454  1.00 31.38 ? 822  VAL   A CB  1 
ATOM   931  C CG1 . VAL   A 1 129 ? -38.620 -14.740 22.555  1.00 31.88 ? 822  VAL   A CG1 1 
ATOM   932  C CG2 . VAL   A 1 129 ? -36.733 -13.703 23.831  1.00 31.91 ? 822  VAL   A CG2 1 
ATOM   933  N N   . GLN   A 1 130 ? -36.850 -13.783 19.335  1.00 30.80 ? 823  GLN   A N   1 
ATOM   934  C CA  . GLN   A 1 130 ? -37.389 -13.772 17.978  1.00 30.62 ? 823  GLN   A CA  1 
ATOM   935  C C   . GLN   A 1 130 ? -36.754 -14.822 17.088  1.00 29.74 ? 823  GLN   A C   1 
ATOM   936  O O   . GLN   A 1 130 ? -37.482 -15.567 16.440  1.00 29.91 ? 823  GLN   A O   1 
ATOM   937  C CB  . GLN   A 1 130 ? -37.295 -12.368 17.350  1.00 32.67 ? 823  GLN   A CB  1 
ATOM   938  C CG  . GLN   A 1 130 ? -38.227 -11.366 18.026  1.00 37.28 ? 823  GLN   A CG  1 
ATOM   939  C CD  . GLN   A 1 130 ? -38.113 -9.968  17.471  1.00 43.02 ? 823  GLN   A CD  1 
ATOM   940  O OE1 . GLN   A 1 130 ? -39.033 -9.456  16.833  1.00 44.87 ? 823  GLN   A OE1 1 
ATOM   941  N NE2 . GLN   A 1 130 ? -36.995 -9.304  17.721  1.00 44.19 ? 823  GLN   A NE2 1 
ATOM   942  N N   . ILE   A 1 131 ? -35.414 -14.926 17.094  1.00 28.74 ? 824  ILE   A N   1 
ATOM   943  C CA  . ILE   A 1 131 ? -34.683 -15.909 16.287  1.00 28.23 ? 824  ILE   A CA  1 
ATOM   944  C C   . ILE   A 1 131 ? -35.027 -17.348 16.709  1.00 28.31 ? 824  ILE   A C   1 
ATOM   945  O O   . ILE   A 1 131 ? -35.159 -18.231 15.863  1.00 28.40 ? 824  ILE   A O   1 
ATOM   946  C CB  . ILE   A 1 131 ? -33.164 -15.617 16.304  1.00 27.99 ? 824  ILE   A CB  1 
ATOM   947  C CG1 . ILE   A 1 131 ? -32.887 -14.209 15.770  1.00 28.41 ? 824  ILE   A CG1 1 
ATOM   948  C CG2 . ILE   A 1 131 ? -32.393 -16.660 15.508  1.00 28.43 ? 824  ILE   A CG2 1 
ATOM   949  C CD1 . ILE   A 1 131 ? -31.507 -13.731 15.978  1.00 29.40 ? 824  ILE   A CD1 1 
ATOM   950  N N   . ALA   A 1 132 ? -35.236 -17.563 18.009  1.00 27.98 ? 825  ALA   A N   1 
ATOM   951  C CA  . ALA   A 1 132 ? -35.633 -18.869 18.517  1.00 28.14 ? 825  ALA   A CA  1 
ATOM   952  C C   . ALA   A 1 132 ? -37.102 -19.152 18.196  1.00 28.49 ? 825  ALA   A C   1 
ATOM   953  O O   . ALA   A 1 132 ? -37.465 -20.303 18.013  1.00 28.97 ? 825  ALA   A O   1 
ATOM   954  C CB  . ALA   A 1 132 ? -35.403 -18.939 20.009  1.00 28.15 ? 825  ALA   A CB  1 
ATOM   955  N N   . LYS   A 1 133 ? -37.942 -18.111 18.119  1.00 28.24 ? 826  LYS   A N   1 
ATOM   956  C CA  . LYS   A 1 133 ? -39.361 -18.223 17.796  1.00 28.50 ? 826  LYS   A CA  1 
ATOM   957  C C   . LYS   A 1 133 ? -39.565 -18.670 16.353  1.00 29.20 ? 826  LYS   A C   1 
ATOM   958  O O   . LYS   A 1 133 ? -40.454 -19.470 16.071  1.00 29.61 ? 826  LYS   A O   1 
ATOM   959  C CB  . LYS   A 1 133 ? -40.090 -16.889 18.051  1.00 29.08 ? 826  LYS   A CB  1 
ATOM   960  C CG  . LYS   A 1 133 ? -40.650 -16.733 19.458  1.00 29.93 ? 826  LYS   A CG  1 
ATOM   961  C CD  . LYS   A 1 133 ? -41.706 -15.658 19.491  1.00 32.06 ? 826  LYS   A CD  1 
ATOM   962  C CE  . LYS   A 1 133 ? -42.001 -15.225 20.899  1.00 35.67 ? 826  LYS   A CE  1 
ATOM   963  N NZ  . LYS   A 1 133 ? -42.886 -14.030 20.945  1.00 37.83 ? 826  LYS   A NZ  1 
ATOM   964  N N   . GLY   A 1 134 ? -38.754 -18.139 15.454  1.00 29.24 ? 827  GLY   A N   1 
ATOM   965  C CA  . GLY   A 1 134 ? -38.831 -18.499 14.052  1.00 29.74 ? 827  GLY   A CA  1 
ATOM   966  C C   . GLY   A 1 134 ? -38.239 -19.866 13.818  1.00 30.32 ? 827  GLY   A C   1 
ATOM   967  O O   . GLY   A 1 134 ? -38.787 -20.653 13.048  1.00 30.59 ? 827  GLY   A O   1 
ATOM   968  N N   . MET   A 1 135 ? -37.130 -20.173 14.499  1.00 30.50 ? 828  MET   A N   1 
ATOM   969  C CA  . MET   A 1 135 ? -36.473 -21.470 14.368  1.00 31.27 ? 828  MET   A CA  1 
ATOM   970  C C   . MET   A 1 135 ? -37.333 -22.614 14.930  1.00 31.98 ? 828  MET   A C   1 
ATOM   971  O O   . MET   A 1 135 ? -37.337 -23.708 14.363  1.00 31.67 ? 828  MET   A O   1 
ATOM   972  C CB  . MET   A 1 135 ? -35.093 -21.446 15.034  1.00 31.82 ? 828  MET   A CB  1 
ATOM   973  C CG  . MET   A 1 135 ? -34.092 -20.541 14.352  1.00 32.99 ? 828  MET   A CG  1 
ATOM   974  S SD  . MET   A 1 135 ? -33.792 -20.966 12.626  1.00 34.55 ? 828  MET   A SD  1 
ATOM   975  C CE  . MET   A 1 135 ? -33.137 -22.589 12.790  1.00 33.54 ? 828  MET   A CE  1 
ATOM   976  N N   . ASN   A 1 136 ? -38.067 -22.357 16.036  1.00 32.58 ? 829  ASN   A N   1 
ATOM   977  C CA  . ASN   A 1 136 ? -38.988 -23.338 16.613  1.00 33.60 ? 829  ASN   A CA  1 
ATOM   978  C C   . ASN   A 1 136 ? -40.114 -23.634 15.615  1.00 34.80 ? 829  ASN   A C   1 
ATOM   979  O O   . ASN   A 1 136 ? -40.555 -24.777 15.539  1.00 35.16 ? 829  ASN   A O   1 
ATOM   980  C CB  . ASN   A 1 136 ? -39.597 -22.828 17.909  1.00 34.70 ? 829  ASN   A CB  1 
ATOM   981  C CG  . ASN   A 1 136 ? -40.322 -23.893 18.700  1.00 38.90 ? 829  ASN   A CG  1 
ATOM   982  O OD1 . ASN   A 1 136 ? -40.064 -25.091 18.563  1.00 40.54 ? 829  ASN   A OD1 1 
ATOM   983  N ND2 . ASN   A 1 136 ? -41.236 -23.488 19.570  1.00 39.96 ? 829  ASN   A ND2 1 
ATOM   984  N N   . TYR   A 1 137 ? -40.559 -22.621 14.829  1.00 35.08 ? 830  TYR   A N   1 
ATOM   985  C CA  . TYR   A 1 137 ? -41.606 -22.792 13.831  1.00 35.70 ? 830  TYR   A CA  1 
ATOM   986  C C   . TYR   A 1 137 ? -41.122 -23.731 12.735  1.00 36.89 ? 830  TYR   A C   1 
ATOM   987  O O   . TYR   A 1 137 ? -41.846 -24.648 12.361  1.00 37.21 ? 830  TYR   A O   1 
ATOM   988  C CB  . TYR   A 1 137 ? -42.049 -21.441 13.251  1.00 35.45 ? 830  TYR   A CB  1 
ATOM   989  C CG  . TYR   A 1 137 ? -43.016 -21.572 12.091  1.00 35.80 ? 830  TYR   A CG  1 
ATOM   990  C CD1 . TYR   A 1 137 ? -44.341 -21.924 12.301  1.00 36.47 ? 830  TYR   A CD1 1 
ATOM   991  C CD2 . TYR   A 1 137 ? -42.601 -21.352 10.785  1.00 36.43 ? 830  TYR   A CD2 1 
ATOM   992  C CE1 . TYR   A 1 137 ? -45.228 -22.057 11.242  1.00 37.10 ? 830  TYR   A CE1 1 
ATOM   993  C CE2 . TYR   A 1 137 ? -43.483 -21.471 9.719   1.00 37.05 ? 830  TYR   A CE2 1 
ATOM   994  C CZ  . TYR   A 1 137 ? -44.796 -21.825 9.952   1.00 37.73 ? 830  TYR   A CZ  1 
ATOM   995  O OH  . TYR   A 1 137 ? -45.669 -21.951 8.902   1.00 38.66 ? 830  TYR   A OH  1 
ATOM   996  N N   . LEU   A 1 138 ? -39.893 -23.526 12.239  1.00 37.22 ? 831  LEU   A N   1 
ATOM   997  C CA  . LEU   A 1 138 ? -39.325 -24.422 11.235  1.00 37.65 ? 831  LEU   A CA  1 
ATOM   998  C C   . LEU   A 1 138 ? -39.127 -25.822 11.828  1.00 38.66 ? 831  LEU   A C   1 
ATOM   999  O O   . LEU   A 1 138 ? -39.308 -26.791 11.116  1.00 38.80 ? 831  LEU   A O   1 
ATOM   1000 C CB  . LEU   A 1 138 ? -38.009 -23.877 10.661  1.00 37.41 ? 831  LEU   A CB  1 
ATOM   1001 C CG  . LEU   A 1 138 ? -38.056 -22.468 10.073  1.00 38.52 ? 831  LEU   A CG  1 
ATOM   1002 C CD1 . LEU   A 1 138 ? -36.720 -22.092 9.495   1.00 39.11 ? 831  LEU   A CD1 1 
ATOM   1003 C CD2 . LEU   A 1 138 ? -39.114 -22.342 8.992   1.00 38.95 ? 831  LEU   A CD2 1 
ATOM   1004 N N   . GLU   A 1 139 ? -38.817 -25.936 13.129  1.00 39.18 ? 832  GLU   A N   1 
ATOM   1005 C CA  . GLU   A 1 139 ? -38.682 -27.229 13.791  1.00 40.43 ? 832  GLU   A CA  1 
ATOM   1006 C C   . GLU   A 1 139 ? -40.044 -27.948 13.774  1.00 41.04 ? 832  GLU   A C   1 
ATOM   1007 O O   . GLU   A 1 139 ? -40.114 -29.130 13.422  1.00 41.18 ? 832  GLU   A O   1 
ATOM   1008 C CB  . GLU   A 1 139 ? -38.176 -27.054 15.250  1.00 43.40 ? 832  GLU   A CB  1 
ATOM   1009 C CG  . GLU   A 1 139 ? -38.160 -28.348 16.052  1.00 49.31 ? 832  GLU   A CG  1 
ATOM   1010 C CD  . GLU   A 1 139 ? -37.300 -28.369 17.300  1.00 58.03 ? 832  GLU   A CD  1 
ATOM   1011 O OE1 . GLU   A 1 139 ? -37.406 -27.426 18.118  1.00 59.98 ? 832  GLU   A OE1 1 
ATOM   1012 O OE2 . GLU   A 1 139 ? -36.531 -29.343 17.470  1.00 61.06 ? 832  GLU   A OE2 1 
ATOM   1013 N N   . ASP   A 1 140 ? -41.125 -27.219 14.111  1.00 41.14 ? 833  ASP   A N   1 
ATOM   1014 C CA  . ASP   A 1 140 ? -42.480 -27.772 14.142  1.00 41.63 ? 833  ASP   A CA  1 
ATOM   1015 C C   . ASP   A 1 140 ? -42.978 -28.112 12.732  1.00 41.61 ? 833  ASP   A C   1 
ATOM   1016 O O   . ASP   A 1 140 ? -43.647 -29.129 12.543  1.00 41.98 ? 833  ASP   A O   1 
ATOM   1017 C CB  . ASP   A 1 140 ? -43.450 -26.848 14.912  1.00 43.59 ? 833  ASP   A CB  1 
ATOM   1018 C CG  . ASP   A 1 140 ? -43.516 -27.098 16.424  1.00 48.75 ? 833  ASP   A CG  1 
ATOM   1019 O OD1 . ASP   A 1 140 ? -42.544 -27.668 16.984  1.00 49.53 ? 833  ASP   A OD1 1 
ATOM   1020 O OD2 . ASP   A 1 140 ? -44.538 -26.722 17.047  1.00 50.97 ? 833  ASP   A OD2 1 
ATOM   1021 N N   . ARG   A 1 141 ? -42.588 -27.306 11.734  1.00 40.97 ? 834  ARG   A N   1 
ATOM   1022 C CA  . ARG   A 1 141 ? -42.915 -27.560 10.327  1.00 40.82 ? 834  ARG   A CA  1 
ATOM   1023 C C   . ARG   A 1 141 ? -41.827 -28.416 9.604   1.00 40.24 ? 834  ARG   A C   1 
ATOM   1024 O O   . ARG   A 1 141 ? -41.787 -28.464 8.373   1.00 40.38 ? 834  ARG   A O   1 
ATOM   1025 C CB  . ARG   A 1 141 ? -43.158 -26.236 9.592   1.00 42.15 ? 834  ARG   A CB  1 
ATOM   1026 C CG  . ARG   A 1 141 ? -44.223 -25.377 10.259  1.00 45.32 ? 834  ARG   A CG  1 
ATOM   1027 C CD  . ARG   A 1 141 ? -45.630 -25.831 9.934   1.00 49.07 ? 834  ARG   A CD  1 
ATOM   1028 N NE  . ARG   A 1 141 ? -45.990 -25.517 8.550   1.00 52.95 ? 834  ARG   A NE  1 
ATOM   1029 C CZ  . ARG   A 1 141 ? -46.819 -26.244 7.804   1.00 55.74 ? 834  ARG   A CZ  1 
ATOM   1030 N NH1 . ARG   A 1 141 ? -47.087 -25.884 6.557   1.00 54.63 ? 834  ARG   A NH1 1 
ATOM   1031 N NH2 . ARG   A 1 141 ? -47.382 -27.340 8.300   1.00 56.86 ? 834  ARG   A NH2 1 
ATOM   1032 N N   . ARG   A 1 142 ? -40.943 -29.060 10.399  1.00 39.23 ? 835  ARG   A N   1 
ATOM   1033 C CA  . ARG   A 1 142 ? -39.835 -29.959 10.091  1.00 38.78 ? 835  ARG   A CA  1 
ATOM   1034 C C   . ARG   A 1 142 ? -38.889 -29.521 8.952   1.00 37.44 ? 835  ARG   A C   1 
ATOM   1035 O O   . ARG   A 1 142 ? -38.300 -30.370 8.293   1.00 37.57 ? 835  ARG   A O   1 
ATOM   1036 C CB  . ARG   A 1 142 ? -40.345 -31.379 9.865   1.00 40.88 ? 835  ARG   A CB  1 
ATOM   1037 C CG  . ARG   A 1 142 ? -40.632 -32.070 11.202  1.00 44.97 ? 835  ARG   A CG  1 
ATOM   1038 C CD  . ARG   A 1 142 ? -42.025 -32.669 11.288  1.00 49.16 ? 835  ARG   A CD  1 
ATOM   1039 N NE  . ARG   A 1 142 ? -42.059 -34.057 10.813  1.00 53.05 ? 835  ARG   A NE  1 
ATOM   1040 C CZ  . ARG   A 1 142 ? -42.548 -34.436 9.636   1.00 55.84 ? 835  ARG   A CZ  1 
ATOM   1041 N NH1 . ARG   A 1 142 ? -42.533 -35.715 9.285   1.00 55.77 ? 835  ARG   A NH1 1 
ATOM   1042 N NH2 . ARG   A 1 142 ? -43.056 -33.538 8.799   1.00 55.77 ? 835  ARG   A NH2 1 
ATOM   1043 N N   . LEU   A 1 143 ? -38.678 -28.211 8.785   1.00 36.06 ? 836  LEU   A N   1 
ATOM   1044 C CA  . LEU   A 1 143 ? -37.686 -27.679 7.854   1.00 35.08 ? 836  LEU   A CA  1 
ATOM   1045 C C   . LEU   A 1 143 ? -36.404 -27.467 8.682   1.00 33.93 ? 836  LEU   A C   1 
ATOM   1046 O O   . LEU   A 1 143 ? -36.451 -27.000 9.823   1.00 34.08 ? 836  LEU   A O   1 
ATOM   1047 C CB  . LEU   A 1 143 ? -38.128 -26.338 7.199   1.00 35.20 ? 836  LEU   A CB  1 
ATOM   1048 C CG  . LEU   A 1 143 ? -37.256 -25.806 6.000   1.00 36.35 ? 836  LEU   A CG  1 
ATOM   1049 C CD1 . LEU   A 1 143 ? -38.099 -25.143 4.948   1.00 36.44 ? 836  LEU   A CD1 1 
ATOM   1050 C CD2 . LEU   A 1 143 ? -36.216 -24.796 6.443   1.00 36.98 ? 836  LEU   A CD2 1 
ATOM   1051 N N   . VAL   A 1 144 ? -35.267 -27.826 8.111   1.00 32.59 ? 837  VAL   A N   1 
ATOM   1052 C CA  . VAL   A 1 144 ? -33.980 -27.651 8.749   1.00 31.74 ? 837  VAL   A CA  1 
ATOM   1053 C C   . VAL   A 1 144 ? -33.210 -26.597 7.954   1.00 30.86 ? 837  VAL   A C   1 
ATOM   1054 O O   . VAL   A 1 144 ? -32.904 -26.797 6.780   1.00 30.98 ? 837  VAL   A O   1 
ATOM   1055 C CB  . VAL   A 1 144 ? -33.238 -28.994 8.881   1.00 32.33 ? 837  VAL   A CB  1 
ATOM   1056 C CG1 . VAL   A 1 144 ? -31.799 -28.787 9.333   1.00 33.01 ? 837  VAL   A CG1 1 
ATOM   1057 C CG2 . VAL   A 1 144 ? -33.977 -29.908 9.849   1.00 32.72 ? 837  VAL   A CG2 1 
ATOM   1058 N N   . HIS   A 1 145 ? -32.997 -25.436 8.579   1.00 29.85 ? 838  HIS   A N   1 
ATOM   1059 C CA  . HIS   A 1 145 ? -32.323 -24.283 8.008   1.00 29.43 ? 838  HIS   A CA  1 
ATOM   1060 C C   . HIS   A 1 145 ? -30.967 -24.613 7.379   1.00 29.92 ? 838  HIS   A C   1 
ATOM   1061 O O   . HIS   A 1 145 ? -30.758 -24.292 6.210   1.00 30.23 ? 838  HIS   A O   1 
ATOM   1062 C CB  . HIS   A 1 145 ? -32.162 -23.209 9.074   1.00 29.20 ? 838  HIS   A CB  1 
ATOM   1063 C CG  . HIS   A 1 145 ? -32.228 -21.831 8.535   1.00 30.43 ? 838  HIS   A CG  1 
ATOM   1064 N ND1 . HIS   A 1 145 ? -31.440 -21.437 7.477   1.00 32.40 ? 838  HIS   A ND1 1 
ATOM   1065 C CD2 . HIS   A 1 145 ? -32.975 -20.784 8.943   1.00 31.44 ? 838  HIS   A CD2 1 
ATOM   1066 C CE1 . HIS   A 1 145 ? -31.743 -20.170 7.261   1.00 32.96 ? 838  HIS   A CE1 1 
ATOM   1067 N NE2 . HIS   A 1 145 ? -32.657 -19.732 8.124   1.00 32.79 ? 838  HIS   A NE2 1 
ATOM   1068 N N   . ARG   A 1 146 ? -30.044 -25.235 8.154   1.00 29.72 ? 839  ARG   A N   1 
ATOM   1069 C CA  . ARG   A 1 146 ? -28.681 -25.626 7.748   1.00 29.63 ? 839  ARG   A CA  1 
ATOM   1070 C C   . ARG   A 1 146 ? -27.700 -24.436 7.592   1.00 29.56 ? 839  ARG   A C   1 
ATOM   1071 O O   . ARG   A 1 146 ? -26.495 -24.643 7.450   1.00 29.71 ? 839  ARG   A O   1 
ATOM   1072 C CB  . ARG   A 1 146 ? -28.686 -26.506 6.497   1.00 30.31 ? 839  ARG   A CB  1 
ATOM   1073 C CG  . ARG   A 1 146 ? -29.548 -27.739 6.640   1.00 32.12 ? 839  ARG   A CG  1 
ATOM   1074 C CD  . ARG   A 1 146 ? -30.095 -28.174 5.300   1.00 34.31 ? 839  ARG   A CD  1 
ATOM   1075 N NE  . ARG   A 1 146 ? -31.114 -29.202 5.481   1.00 36.13 ? 839  ARG   A NE  1 
ATOM   1076 C CZ  . ARG   A 1 146 ? -30.866 -30.505 5.522   1.00 38.01 ? 839  ARG   A CZ  1 
ATOM   1077 N NH1 . ARG   A 1 146 ? -31.853 -31.368 5.710   1.00 37.84 ? 839  ARG   A NH1 1 
ATOM   1078 N NH2 . ARG   A 1 146 ? -29.630 -30.958 5.357   1.00 38.09 ? 839  ARG   A NH2 1 
ATOM   1079 N N   . ASP   A 1 147 ? -28.209 -23.205 7.638   1.00 29.15 ? 840  ASP   A N   1 
ATOM   1080 C CA  . ASP   A 1 147 ? -27.379 -22.017 7.568   1.00 29.16 ? 840  ASP   A CA  1 
ATOM   1081 C C   . ASP   A 1 147 ? -28.051 -20.853 8.277   1.00 29.18 ? 840  ASP   A C   1 
ATOM   1082 O O   . ASP   A 1 147 ? -28.640 -19.984 7.632   1.00 29.66 ? 840  ASP   A O   1 
ATOM   1083 C CB  . ASP   A 1 147 ? -27.023 -21.628 6.134   1.00 30.44 ? 840  ASP   A CB  1 
ATOM   1084 C CG  . ASP   A 1 147 ? -26.052 -20.467 6.113   1.00 34.36 ? 840  ASP   A CG  1 
ATOM   1085 O OD1 . ASP   A 1 147 ? -25.164 -20.418 7.000   1.00 34.31 ? 840  ASP   A OD1 1 
ATOM   1086 O OD2 . ASP   A 1 147 ? -26.211 -19.574 5.248   1.00 36.85 ? 840  ASP   A OD2 1 
ATOM   1087 N N   . LEU   A 1 148 ? -27.961 -20.837 9.602   1.00 28.38 ? 841  LEU   A N   1 
ATOM   1088 C CA  . LEU   A 1 148 ? -28.502 -19.753 10.391  1.00 27.96 ? 841  LEU   A CA  1 
ATOM   1089 C C   . LEU   A 1 148 ? -27.308 -18.993 10.924  1.00 27.85 ? 841  LEU   A C   1 
ATOM   1090 O O   . LEU   A 1 148 ? -26.378 -19.586 11.473  1.00 28.48 ? 841  LEU   A O   1 
ATOM   1091 C CB  . LEU   A 1 148 ? -29.377 -20.276 11.541  1.00 28.02 ? 841  LEU   A CB  1 
ATOM   1092 C CG  . LEU   A 1 148 ? -29.848 -19.214 12.533  1.00 29.62 ? 841  LEU   A CG  1 
ATOM   1093 C CD1 . LEU   A 1 148 ? -30.778 -18.216 11.880  1.00 30.20 ? 841  LEU   A CD1 1 
ATOM   1094 C CD2 . LEU   A 1 148 ? -30.502 -19.837 13.742  1.00 30.41 ? 841  LEU   A CD2 1 
ATOM   1095 N N   . ALA   A 1 149 ? -27.315 -17.686 10.723  1.00 27.01 ? 842  ALA   A N   1 
ATOM   1096 C CA  . ALA   A 1 149 ? -26.269 -16.769 11.171  1.00 26.69 ? 842  ALA   A CA  1 
ATOM   1097 C C   . ALA   A 1 149 ? -26.876 -15.352 11.226  1.00 25.95 ? 842  ALA   A C   1 
ATOM   1098 O O   . ALA   A 1 149 ? -27.976 -15.143 10.705  1.00 26.09 ? 842  ALA   A O   1 
ATOM   1099 C CB  . ALA   A 1 149 ? -25.098 -16.812 10.188  1.00 26.98 ? 842  ALA   A CB  1 
ATOM   1100 N N   . ALA   A 1 150 ? -26.180 -14.377 11.835  1.00 24.98 ? 843  ALA   A N   1 
ATOM   1101 C CA  . ALA   A 1 150 ? -26.675 -13.002 11.880  1.00 24.67 ? 843  ALA   A CA  1 
ATOM   1102 C C   . ALA   A 1 150 ? -26.933 -12.409 10.481  1.00 24.42 ? 843  ALA   A C   1 
ATOM   1103 O O   . ALA   A 1 150 ? -27.705 -11.460 10.361  1.00 24.74 ? 843  ALA   A O   1 
ATOM   1104 C CB  . ALA   A 1 150 ? -25.701 -12.129 12.642  1.00 24.83 ? 843  ALA   A CB  1 
ATOM   1105 N N   . ARG   A 1 151 ? -26.312 -12.975 9.427   1.00 23.70 ? 844  ARG   A N   1 
ATOM   1106 C CA  . ARG   A 1 151 ? -26.493 -12.512 8.043   1.00 23.59 ? 844  ARG   A CA  1 
ATOM   1107 C C   . ARG   A 1 151 ? -27.832 -12.973 7.465   1.00 23.45 ? 844  ARG   A C   1 
ATOM   1108 O O   . ARG   A 1 151 ? -28.438 -12.261 6.671   1.00 23.05 ? 844  ARG   A O   1 
ATOM   1109 C CB  . ARG   A 1 151 ? -25.351 -12.990 7.115   1.00 24.28 ? 844  ARG   A CB  1 
ATOM   1110 C CG  . ARG   A 1 151 ? -24.134 -13.610 7.807   1.00 25.97 ? 844  ARG   A CG  1 
ATOM   1111 C CD  . ARG   A 1 151 ? -23.254 -14.334 6.809   1.00 27.21 ? 844  ARG   A CD  1 
ATOM   1112 N NE  . ARG   A 1 151 ? -23.845 -15.607 6.398   1.00 27.76 ? 844  ARG   A NE  1 
ATOM   1113 C CZ  . ARG   A 1 151 ? -23.471 -16.794 6.863   1.00 28.31 ? 844  ARG   A CZ  1 
ATOM   1114 N NH1 . ARG   A 1 151 ? -24.063 -17.897 6.433   1.00 27.16 ? 844  ARG   A NH1 1 
ATOM   1115 N NH2 . ARG   A 1 151 ? -22.487 -16.890 7.748   1.00 28.02 ? 844  ARG   A NH2 1 
ATOM   1116 N N   . ASN   A 1 152 ? -28.282 -14.179 7.843   1.00 23.59 ? 845  ASN   A N   1 
ATOM   1117 C CA  . ASN   A 1 152 ? -29.545 -14.737 7.350   1.00 23.90 ? 845  ASN   A CA  1 
ATOM   1118 C C   . ASN   A 1 152 ? -30.739 -14.437 8.270   1.00 24.19 ? 845  ASN   A C   1 
ATOM   1119 O O   . ASN   A 1 152 ? -31.715 -15.193 8.287   1.00 24.31 ? 845  ASN   A O   1 
ATOM   1120 C CB  . ASN   A 1 152 ? -29.401 -16.234 7.071   1.00 24.49 ? 845  ASN   A CB  1 
ATOM   1121 C CG  . ASN   A 1 152 ? -28.357 -16.518 6.017   1.00 27.48 ? 845  ASN   A CG  1 
ATOM   1122 O OD1 . ASN   A 1 152 ? -27.479 -17.362 6.190   1.00 28.67 ? 845  ASN   A OD1 1 
ATOM   1123 N ND2 . ASN   A 1 152 ? -28.407 -15.799 4.904   1.00 27.97 ? 845  ASN   A ND2 1 
ATOM   1124 N N   . VAL   A 1 153 ? -30.650 -13.327 9.031   1.00 23.92 ? 846  VAL   A N   1 
ATOM   1125 C CA  . VAL   A 1 153 ? -31.669 -12.836 9.951   1.00 24.26 ? 846  VAL   A CA  1 
ATOM   1126 C C   . VAL   A 1 153 ? -31.814 -11.369 9.622   1.00 24.74 ? 846  VAL   A C   1 
ATOM   1127 O O   . VAL   A 1 153 ? -30.916 -10.596 9.931   1.00 25.09 ? 846  VAL   A O   1 
ATOM   1128 C CB  . VAL   A 1 153 ? -31.244 -13.032 11.426  1.00 24.69 ? 846  VAL   A CB  1 
ATOM   1129 C CG1 . VAL   A 1 153 ? -32.161 -12.262 12.365  1.00 24.90 ? 846  VAL   A CG1 1 
ATOM   1130 C CG2 . VAL   A 1 153 ? -31.221 -14.512 11.794  1.00 25.30 ? 846  VAL   A CG2 1 
ATOM   1131 N N   . LEU   A 1 154 ? -32.908 -10.987 8.956   1.00 24.66 ? 847  LEU   A N   1 
ATOM   1132 C CA  . LEU   A 1 154 ? -33.154 -9.618  8.501   1.00 25.14 ? 847  LEU   A CA  1 
ATOM   1133 C C   . LEU   A 1 154 ? -34.015 -8.764  9.402   1.00 25.30 ? 847  LEU   A C   1 
ATOM   1134 O O   . LEU   A 1 154 ? -35.096 -9.172  9.813   1.00 25.73 ? 847  LEU   A O   1 
ATOM   1135 C CB  . LEU   A 1 154 ? -33.791 -9.624  7.120   1.00 25.32 ? 847  LEU   A CB  1 
ATOM   1136 C CG  . LEU   A 1 154 ? -33.060 -10.399 6.058   1.00 27.17 ? 847  LEU   A CG  1 
ATOM   1137 C CD1 . LEU   A 1 154 ? -34.005 -10.762 4.960   1.00 28.26 ? 847  LEU   A CD1 1 
ATOM   1138 C CD2 . LEU   A 1 154 ? -31.880 -9.617  5.521   1.00 27.59 ? 847  LEU   A CD2 1 
ATOM   1139 N N   . VAL   A 1 155 ? -33.574 -7.534  9.611   1.00 24.67 ? 848  VAL   A N   1 
ATOM   1140 C CA  . VAL   A 1 155 ? -34.271 -6.527  10.376  1.00 24.56 ? 848  VAL   A CA  1 
ATOM   1141 C C   . VAL   A 1 155 ? -35.447 -5.998  9.553   1.00 24.66 ? 848  VAL   A C   1 
ATOM   1142 O O   . VAL   A 1 155 ? -35.248 -5.380  8.496   1.00 24.78 ? 848  VAL   A O   1 
ATOM   1143 C CB  . VAL   A 1 155 ? -33.266 -5.399  10.705  1.00 25.31 ? 848  VAL   A CB  1 
ATOM   1144 C CG1 . VAL   A 1 155 ? -33.959 -4.150  11.234  1.00 25.80 ? 848  VAL   A CG1 1 
ATOM   1145 C CG2 . VAL   A 1 155 ? -32.208 -5.887  11.681  1.00 26.00 ? 848  VAL   A CG2 1 
ATOM   1146 N N   . LYS   A 1 156 ? -36.676 -6.271  10.007  1.00 24.31 ? 849  LYS   A N   1 
ATOM   1147 C CA  . LYS   A 1 156 ? -37.864 -5.726  9.350   1.00 24.62 ? 849  LYS   A CA  1 
ATOM   1148 C C   . LYS   A 1 156 ? -37.908 -4.265  9.851   1.00 24.25 ? 849  LYS   A C   1 
ATOM   1149 O O   . LYS   A 1 156 ? -37.778 -3.325  9.056   1.00 23.96 ? 849  LYS   A O   1 
ATOM   1150 C CB  . LYS   A 1 156 ? -39.138 -6.523  9.731   1.00 26.55 ? 849  LYS   A CB  1 
ATOM   1151 C CG  . LYS   A 1 156 ? -40.411 -5.988  9.082   1.00 31.12 ? 849  LYS   A CG  1 
ATOM   1152 C CD  . LYS   A 1 156 ? -41.382 -7.104  8.720   1.00 36.25 ? 849  LYS   A CD  1 
ATOM   1153 C CE  . LYS   A 1 156 ? -42.548 -6.667  7.862   1.00 41.02 ? 849  LYS   A CE  1 
ATOM   1154 N NZ  . LYS   A 1 156 ? -42.239 -6.720  6.394   1.00 44.16 ? 849  LYS   A NZ  1 
ATOM   1155 N N   . THR   A 1 157 ? -37.982 -4.109  11.202  1.00 23.65 ? 850  THR   A N   1 
ATOM   1156 C CA  . THR   A 1 157 ? -37.926 -2.885  12.006  1.00 23.33 ? 850  THR   A CA  1 
ATOM   1157 C C   . THR   A 1 157 ? -36.889 -3.165  13.139  1.00 24.04 ? 850  THR   A C   1 
ATOM   1158 O O   . THR   A 1 157 ? -36.657 -4.334  13.457  1.00 24.26 ? 850  THR   A O   1 
ATOM   1159 C CB  . THR   A 1 157 ? -39.327 -2.559  12.581  1.00 23.76 ? 850  THR   A CB  1 
ATOM   1160 O OG1 . THR   A 1 157 ? -39.649 -3.442  13.648  1.00 24.93 ? 850  THR   A OG1 1 
ATOM   1161 C CG2 . THR   A 1 157 ? -40.425 -2.618  11.553  1.00 23.92 ? 850  THR   A CG2 1 
ATOM   1162 N N   . PRO   A 1 158 ? -36.288 -2.157  13.804  1.00 24.36 ? 851  PRO   A N   1 
ATOM   1163 C CA  . PRO   A 1 158 ? -35.337 -2.450  14.897  1.00 24.41 ? 851  PRO   A CA  1 
ATOM   1164 C C   . PRO   A 1 158 ? -35.833 -3.404  15.996  1.00 24.54 ? 851  PRO   A C   1 
ATOM   1165 O O   . PRO   A 1 158 ? -35.000 -3.936  16.729  1.00 24.97 ? 851  PRO   A O   1 
ATOM   1166 C CB  . PRO   A 1 158 ? -34.995 -1.069  15.469  1.00 25.18 ? 851  PRO   A CB  1 
ATOM   1167 C CG  . PRO   A 1 158 ? -36.005 -0.136  14.913  1.00 25.71 ? 851  PRO   A CG  1 
ATOM   1168 C CD  . PRO   A 1 158 ? -36.399 -0.708  13.582  1.00 24.20 ? 851  PRO   A CD  1 
ATOM   1169 N N   . GLN   A 1 159 ? -37.157 -3.635  16.129  1.00 23.91 ? 852  GLN   A N   1 
ATOM   1170 C CA  . GLN   A 1 159 ? -37.652 -4.615  17.110  1.00 23.66 ? 852  GLN   A CA  1 
ATOM   1171 C C   . GLN   A 1 159 ? -38.367 -5.811  16.458  1.00 22.83 ? 852  GLN   A C   1 
ATOM   1172 O O   . GLN   A 1 159 ? -39.194 -6.468  17.089  1.00 22.20 ? 852  GLN   A O   1 
ATOM   1173 C CB  . GLN   A 1 159 ? -38.521 -3.967  18.196  1.00 25.40 ? 852  GLN   A CB  1 
ATOM   1174 C CG  . GLN   A 1 159 ? -39.672 -3.135  17.678  1.00 28.56 ? 852  GLN   A CG  1 
ATOM   1175 C CD  . GLN   A 1 159 ? -39.294 -1.692  17.753  1.00 32.70 ? 852  GLN   A CD  1 
ATOM   1176 O OE1 . GLN   A 1 159 ? -38.624 -1.169  16.860  1.00 35.42 ? 852  GLN   A OE1 1 
ATOM   1177 N NE2 . GLN   A 1 159 ? -39.689 -1.028  18.826  1.00 31.80 ? 852  GLN   A NE2 1 
ATOM   1178 N N   . HIS   A 1 160 ? -38.032 -6.098  15.193  1.00 22.61 ? 853  HIS   A N   1 
ATOM   1179 C CA  . HIS   A 1 160 ? -38.639 -7.189  14.451  1.00 22.63 ? 853  HIS   A CA  1 
ATOM   1180 C C   . HIS   A 1 160 ? -37.689 -7.831  13.484  1.00 22.37 ? 853  HIS   A C   1 
ATOM   1181 O O   . HIS   A 1 160 ? -37.565 -7.367  12.368  1.00 22.58 ? 853  HIS   A O   1 
ATOM   1182 C CB  . HIS   A 1 160 ? -39.881 -6.708  13.694  1.00 23.43 ? 853  HIS   A CB  1 
ATOM   1183 C CG  . HIS   A 1 160 ? -40.750 -7.811  13.188  1.00 25.79 ? 853  HIS   A CG  1 
ATOM   1184 N ND1 . HIS   A 1 160 ? -40.762 -9.063  13.784  1.00 27.76 ? 853  HIS   A ND1 1 
ATOM   1185 C CD2 . HIS   A 1 160 ? -41.654 -7.798  12.184  1.00 27.20 ? 853  HIS   A CD2 1 
ATOM   1186 C CE1 . HIS   A 1 160 ? -41.644 -9.774  13.108  1.00 28.47 ? 853  HIS   A CE1 1 
ATOM   1187 N NE2 . HIS   A 1 160 ? -42.206 -9.059  12.133  1.00 28.51 ? 853  HIS   A NE2 1 
ATOM   1188 N N   . VAL   A 1 161 ? -37.051 -8.919  13.885  1.00 22.22 ? 854  VAL   A N   1 
ATOM   1189 C CA  . VAL   A 1 161 ? -36.140 -9.645  13.015  1.00 22.70 ? 854  VAL   A CA  1 
ATOM   1190 C C   . VAL   A 1 161 ? -36.825 -10.892 12.436  1.00 22.99 ? 854  VAL   A C   1 
ATOM   1191 O O   . VAL   A 1 161 ? -37.721 -11.466 13.061  1.00 22.68 ? 854  VAL   A O   1 
ATOM   1192 C CB  . VAL   A 1 161 ? -34.761 -9.932  13.659  1.00 23.63 ? 854  VAL   A CB  1 
ATOM   1193 C CG1 . VAL   A 1 161 ? -33.846 -8.719  13.517  1.00 24.45 ? 854  VAL   A CG1 1 
ATOM   1194 C CG2 . VAL   A 1 161 ? -34.883 -10.359 15.127  1.00 23.87 ? 854  VAL   A CG2 1 
ATOM   1195 N N   . LYS   A 1 162 ? -36.463 -11.247 11.192  1.00 23.38 ? 855  LYS   A N   1 
ATOM   1196 C CA  . LYS   A 1 162 ? -37.052 -12.357 10.460  1.00 24.39 ? 855  LYS   A CA  1 
ATOM   1197 C C   . LYS   A 1 162 ? -35.950 -13.191 9.840   1.00 25.88 ? 855  LYS   A C   1 
ATOM   1198 O O   . LYS   A 1 162 ? -35.041 -12.632 9.256   1.00 25.92 ? 855  LYS   A O   1 
ATOM   1199 C CB  . LYS   A 1 162 ? -37.934 -11.812 9.334   1.00 25.85 ? 855  LYS   A CB  1 
ATOM   1200 C CG  . LYS   A 1 162 ? -39.159 -11.048 9.791   1.00 29.47 ? 855  LYS   A CG  1 
ATOM   1201 C CD  . LYS   A 1 162 ? -39.823 -10.361 8.613   1.00 33.96 ? 855  LYS   A CD  1 
ATOM   1202 C CE  . LYS   A 1 162 ? -41.243 -10.817 8.398   1.00 37.98 ? 855  LYS   A CE  1 
ATOM   1203 N NZ  . LYS   A 1 162 ? -41.305 -12.269 8.088   1.00 40.78 ? 855  LYS   A NZ  1 
ATOM   1204 N N   . ILE   A 1 163 ? -36.050 -14.519 9.902   1.00 26.95 ? 856  ILE   A N   1 
ATOM   1205 C CA  . ILE   A 1 163 ? -35.029 -15.400 9.333   1.00 28.30 ? 856  ILE   A CA  1 
ATOM   1206 C C   . ILE   A 1 163 ? -35.306 -15.691 7.876   1.00 29.47 ? 856  ILE   A C   1 
ATOM   1207 O O   . ILE   A 1 163 ? -36.436 -16.002 7.530   1.00 29.39 ? 856  ILE   A O   1 
ATOM   1208 C CB  . ILE   A 1 163 ? -34.960 -16.703 10.153  1.00 29.20 ? 856  ILE   A CB  1 
ATOM   1209 C CG1 . ILE   A 1 163 ? -34.737 -16.414 11.640  1.00 30.27 ? 856  ILE   A CG1 1 
ATOM   1210 C CG2 . ILE   A 1 163 ? -33.895 -17.642 9.613   1.00 29.86 ? 856  ILE   A CG2 1 
ATOM   1211 C CD1 . ILE   A 1 163 ? -35.650 -17.179 12.525  1.00 31.82 ? 856  ILE   A CD1 1 
ATOM   1212 N N   . THR   A 1 164 ? -34.268 -15.611 7.026   1.00 30.86 ? 857  THR   A N   1 
ATOM   1213 C CA  . THR   A 1 164 ? -34.304 -15.845 5.562   1.00 32.40 ? 857  THR   A CA  1 
ATOM   1214 C C   . THR   A 1 164 ? -33.266 -16.933 5.155   1.00 34.20 ? 857  THR   A C   1 
ATOM   1215 O O   . THR   A 1 164 ? -32.457 -17.336 5.987   1.00 34.69 ? 857  THR   A O   1 
ATOM   1216 C CB  . THR   A 1 164 ? -33.981 -14.509 4.860   1.00 33.49 ? 857  THR   A CB  1 
ATOM   1217 O OG1 . THR   A 1 164 ? -34.321 -14.557 3.471   1.00 34.55 ? 857  THR   A OG1 1 
ATOM   1218 C CG2 . THR   A 1 164 ? -32.525 -14.122 5.013   1.00 33.89 ? 857  THR   A CG2 1 
ATOM   1219 N N   . ASP   A 1 165 ? -33.281 -17.392 3.890   1.00 35.41 ? 858  ASP   A N   1 
ATOM   1220 C CA  . ASP   A 1 165 ? -32.343 -18.390 3.354   1.00 37.27 ? 858  ASP   A CA  1 
ATOM   1221 C C   . ASP   A 1 165 ? -32.475 -19.761 4.017   1.00 38.82 ? 858  ASP   A C   1 
ATOM   1222 O O   . ASP   A 1 165 ? -31.469 -20.447 4.238   1.00 38.98 ? 858  ASP   A O   1 
ATOM   1223 C CB  . ASP   A 1 165 ? -30.877 -17.905 3.399   1.00 39.33 ? 858  ASP   A CB  1 
ATOM   1224 C CG  . ASP   A 1 165 ? -30.414 -17.025 2.253   1.00 44.45 ? 858  ASP   A CG  1 
ATOM   1225 O OD1 . ASP   A 1 165 ? -30.937 -17.190 1.121   1.00 45.36 ? 858  ASP   A OD1 1 
ATOM   1226 O OD2 . ASP   A 1 165 ? -29.510 -16.183 2.481   1.00 46.65 ? 858  ASP   A OD2 1 
ATOM   1227 N N   . PHE   A 1 166 ? -33.706 -20.162 4.331   1.00 39.86 ? 859  PHE   A N   1 
ATOM   1228 C CA  . PHE   A 1 166 ? -33.921 -21.476 4.924   1.00 41.56 ? 859  PHE   A CA  1 
ATOM   1229 C C   . PHE   A 1 166 ? -34.161 -22.511 3.829   1.00 42.23 ? 859  PHE   A C   1 
ATOM   1230 O O   . PHE   A 1 166 ? -34.793 -22.207 2.818   1.00 42.29 ? 859  PHE   A O   1 
ATOM   1231 C CB  . PHE   A 1 166 ? -35.028 -21.461 5.989   1.00 42.24 ? 859  PHE   A CB  1 
ATOM   1232 C CG  . PHE   A 1 166 ? -36.332 -20.845 5.556   1.00 43.64 ? 859  PHE   A CG  1 
ATOM   1233 C CD1 . PHE   A 1 166 ? -37.318 -21.615 4.959   1.00 44.76 ? 859  PHE   A CD1 1 
ATOM   1234 C CD2 . PHE   A 1 166 ? -36.591 -19.505 5.781   1.00 44.63 ? 859  PHE   A CD2 1 
ATOM   1235 C CE1 . PHE   A 1 166 ? -38.521 -21.047 4.563   1.00 45.56 ? 859  PHE   A CE1 1 
ATOM   1236 C CE2 . PHE   A 1 166 ? -37.795 -18.943 5.392   1.00 45.51 ? 859  PHE   A CE2 1 
ATOM   1237 C CZ  . PHE   A 1 166 ? -38.758 -19.719 4.792   1.00 45.34 ? 859  PHE   A CZ  1 
ATOM   1238 N N   . GLY   A 1 167 ? -33.583 -23.697 4.001   1.00 42.57 ? 860  GLY   A N   1 
ATOM   1239 C CA  . GLY   A 1 167 ? -33.695 -24.779 3.026   1.00 43.27 ? 860  GLY   A CA  1 
ATOM   1240 C C   . GLY   A 1 167 ? -32.878 -24.594 1.756   1.00 43.62 ? 860  GLY   A C   1 
ATOM   1241 O O   . GLY   A 1 167 ? -32.837 -25.490 0.906   1.00 43.73 ? 860  GLY   A O   1 
ATOM   1242 N N   . LEU   A 1 168 ? -32.213 -23.431 1.622   1.00 43.52 ? 861  LEU   A N   1 
ATOM   1243 C CA  . LEU   A 1 168 ? -31.373 -23.077 0.487   1.00 43.74 ? 861  LEU   A CA  1 
ATOM   1244 C C   . LEU   A 1 168 ? -30.178 -24.013 0.387   1.00 44.15 ? 861  LEU   A C   1 
ATOM   1245 O O   . LEU   A 1 168 ? -29.845 -24.455 -0.704  1.00 44.40 ? 861  LEU   A O   1 
ATOM   1246 C CB  . LEU   A 1 168 ? -30.907 -21.631 0.624   1.00 43.77 ? 861  LEU   A CB  1 
ATOM   1247 C CG  . LEU   A 1 168 ? -30.193 -21.089 -0.583  1.00 45.21 ? 861  LEU   A CG  1 
ATOM   1248 C CD1 . LEU   A 1 168 ? -30.970 -19.953 -1.194  1.00 45.72 ? 861  LEU   A CD1 1 
ATOM   1249 C CD2 . LEU   A 1 168 ? -28.782 -20.675 -0.233  1.00 46.02 ? 861  LEU   A CD2 1 
ATOM   1250 N N   . ALA   A 1 169 ? -29.578 -24.372 1.522   1.00 44.24 ? 862  ALA   A N   1 
ATOM   1251 C CA  . ALA   A 1 169 ? -28.458 -25.307 1.558   1.00 44.84 ? 862  ALA   A CA  1 
ATOM   1252 C C   . ALA   A 1 169 ? -28.897 -26.681 1.031   1.00 45.27 ? 862  ALA   A C   1 
ATOM   1253 O O   . ALA   A 1 169 ? -28.131 -27.341 0.329   1.00 45.67 ? 862  ALA   A O   1 
ATOM   1254 C CB  . ALA   A 1 169 ? -27.938 -25.436 2.980   1.00 45.11 ? 862  ALA   A CB  1 
ATOM   1255 N N   . LYS   A 1 170 ? -30.134 -27.108 1.356   1.00 44.97 ? 863  LYS   A N   1 
ATOM   1256 C CA  . LYS   A 1 170 ? -30.678 -28.380 0.868   1.00 44.83 ? 863  LYS   A CA  1 
ATOM   1257 C C   . LYS   A 1 170 ? -30.890 -28.299 -0.640  1.00 44.55 ? 863  LYS   A C   1 
ATOM   1258 O O   . LYS   A 1 170 ? -30.595 -29.253 -1.354  1.00 44.48 ? 863  LYS   A O   1 
ATOM   1259 C CB  . LYS   A 1 170 ? -31.999 -28.738 1.577   1.00 46.36 ? 863  LYS   A CB  1 
ATOM   1260 C CG  . LYS   A 1 170 ? -32.383 -30.209 1.416   1.00 49.82 ? 863  LYS   A CG  1 
ATOM   1261 C CD  . LYS   A 1 170 ? -33.862 -30.466 1.701   1.00 53.97 ? 863  LYS   A CD  1 
ATOM   1262 C CE  . LYS   A 1 170 ? -34.217 -31.940 1.713   1.00 57.63 ? 863  LYS   A CE  1 
ATOM   1263 N NZ  . LYS   A 1 170 ? -33.919 -32.606 0.414   1.00 60.03 ? 863  LYS   A NZ  1 
ATOM   1264 N N   . LEU   A 1 171 ? -31.385 -27.150 -1.113  1.00 44.33 ? 864  LEU   A N   1 
ATOM   1265 C CA  . LEU   A 1 171 ? -31.619 -26.842 -2.519  1.00 44.97 ? 864  LEU   A CA  1 
ATOM   1266 C C   . LEU   A 1 171 ? -30.312 -26.981 -3.324  1.00 46.00 ? 864  LEU   A C   1 
ATOM   1267 O O   . LEU   A 1 171 ? -30.345 -27.444 -4.467  1.00 46.35 ? 864  LEU   A O   1 
ATOM   1268 C CB  . LEU   A 1 171 ? -32.173 -25.404 -2.613  1.00 44.66 ? 864  LEU   A CB  1 
ATOM   1269 C CG  . LEU   A 1 171 ? -33.091 -25.027 -3.770  1.00 45.29 ? 864  LEU   A CG  1 
ATOM   1270 C CD1 . LEU   A 1 171 ? -32.308 -24.692 -5.018  1.00 45.79 ? 864  LEU   A CD1 1 
ATOM   1271 C CD2 . LEU   A 1 171 ? -34.195 -26.040 -3.980  1.00 45.52 ? 864  LEU   A CD2 1 
ATOM   1272 N N   . LEU   A 1 172 ? -29.161 -26.613 -2.725  1.00 46.15 ? 865  LEU   A N   1 
ATOM   1273 C CA  . LEU   A 1 172 ? -27.876 -26.713 -3.416  1.00 46.64 ? 865  LEU   A CA  1 
ATOM   1274 C C   . LEU   A 1 172 ? -26.850 -27.637 -2.673  1.00 47.31 ? 865  LEU   A C   1 
ATOM   1275 O O   . LEU   A 1 172 ? -27.216 -28.346 -1.729  1.00 47.31 ? 865  LEU   A O   1 
ATOM   1276 C CB  . LEU   A 1 172 ? -27.315 -25.300 -3.718  1.00 46.58 ? 865  LEU   A CB  1 
ATOM   1277 C CG  . LEU   A 1 172 ? -27.250 -24.332 -2.558  1.00 47.72 ? 865  LEU   A CG  1 
ATOM   1278 C CD1 . LEU   A 1 172 ? -25.844 -24.195 -2.045  1.00 48.23 ? 865  LEU   A CD1 1 
ATOM   1279 C CD2 . LEU   A 1 172 ? -27.768 -22.987 -2.964  1.00 48.35 ? 865  LEU   A CD2 1 
ATOM   1280 N N   . GLY   A 1 173 ? -25.605 -27.659 -3.151  1.00 47.68 ? 866  GLY   A N   1 
ATOM   1281 C CA  . GLY   A 1 173 ? -24.532 -28.478 -2.605  1.00 48.58 ? 866  GLY   A CA  1 
ATOM   1282 C C   . GLY   A 1 173 ? -23.277 -28.436 -3.462  1.00 49.25 ? 866  GLY   A C   1 
ATOM   1283 O O   . GLY   A 1 173 ? -23.334 -28.537 -4.694  1.00 49.57 ? 866  GLY   A O   1 
ATOM   1284 N N   . VAL   A 1 186 ? -20.139 -23.333 2.186   1.00 24.41 ? 879  VAL   A N   1 
ATOM   1285 C CA  . VAL   A 1 186 ? -20.127 -24.087 3.453   1.00 25.15 ? 879  VAL   A CA  1 
ATOM   1286 C C   . VAL   A 1 186 ? -19.648 -23.234 4.692   1.00 25.08 ? 879  VAL   A C   1 
ATOM   1287 O O   . VAL   A 1 186 ? -18.452 -22.971 4.854   1.00 25.27 ? 879  VAL   A O   1 
ATOM   1288 C CB  . VAL   A 1 186 ? -19.331 -25.409 3.298   1.00 26.14 ? 879  VAL   A CB  1 
ATOM   1289 C CG1 . VAL   A 1 186 ? -17.970 -25.178 2.632   1.00 26.83 ? 879  VAL   A CG1 1 
ATOM   1290 C CG2 . VAL   A 1 186 ? -19.187 -26.131 4.632   1.00 26.49 ? 879  VAL   A CG2 1 
ATOM   1291 N N   . PRO   A 1 187 ? -20.575 -22.802 5.579   1.00 24.63 ? 880  PRO   A N   1 
ATOM   1292 C CA  . PRO   A 1 187 ? -20.165 -21.955 6.725   1.00 24.44 ? 880  PRO   A CA  1 
ATOM   1293 C C   . PRO   A 1 187 ? -19.603 -22.729 7.916   1.00 24.40 ? 880  PRO   A C   1 
ATOM   1294 O O   . PRO   A 1 187 ? -20.285 -22.885 8.934   1.00 24.30 ? 880  PRO   A O   1 
ATOM   1295 C CB  . PRO   A 1 187 ? -21.458 -21.223 7.094   1.00 25.10 ? 880  PRO   A CB  1 
ATOM   1296 C CG  . PRO   A 1 187 ? -22.532 -22.201 6.737   1.00 25.67 ? 880  PRO   A CG  1 
ATOM   1297 C CD  . PRO   A 1 187 ? -22.039 -22.996 5.542   1.00 24.10 ? 880  PRO   A CD  1 
ATOM   1298 N N   . ILE   A 1 188 ? -18.349 -23.183 7.805   1.00 24.31 ? 881  ILE   A N   1 
ATOM   1299 C CA  . ILE   A 1 188 ? -17.701 -23.989 8.841   1.00 24.92 ? 881  ILE   A CA  1 
ATOM   1300 C C   . ILE   A 1 188 ? -17.820 -23.410 10.258  1.00 25.02 ? 881  ILE   A C   1 
ATOM   1301 O O   . ILE   A 1 188 ? -18.271 -24.116 11.156  1.00 24.99 ? 881  ILE   A O   1 
ATOM   1302 C CB  . ILE   A 1 188 ? -16.237 -24.283 8.464   1.00 25.61 ? 881  ILE   A CB  1 
ATOM   1303 C CG1 . ILE   A 1 188 ? -16.186 -25.165 7.206   1.00 26.56 ? 881  ILE   A CG1 1 
ATOM   1304 C CG2 . ILE   A 1 188 ? -15.487 -24.948 9.627   1.00 26.06 ? 881  ILE   A CG2 1 
ATOM   1305 C CD1 . ILE   A 1 188 ? -16.839 -26.551 7.389   1.00 27.77 ? 881  ILE   A CD1 1 
ATOM   1306 N N   . LYS   A 1 189 ? -17.469 -22.132 10.439  1.00 25.12 ? 882  LYS   A N   1 
ATOM   1307 C CA  . LYS   A 1 189 ? -17.497 -21.437 11.729  1.00 25.76 ? 882  LYS   A CA  1 
ATOM   1308 C C   . LYS   A 1 189 ? -18.887 -21.262 12.365  1.00 25.78 ? 882  LYS   A C   1 
ATOM   1309 O O   . LYS   A 1 189 ? -19.003 -20.536 13.346  1.00 25.81 ? 882  LYS   A O   1 
ATOM   1310 C CB  . LYS   A 1 189 ? -16.810 -20.068 11.615  1.00 27.90 ? 882  LYS   A CB  1 
ATOM   1311 C CG  . LYS   A 1 189 ? -15.311 -20.137 11.354  1.00 32.32 ? 882  LYS   A CG  1 
ATOM   1312 C CD  . LYS   A 1 189 ? -14.806 -18.760 10.954  1.00 37.54 ? 882  LYS   A CD  1 
ATOM   1313 C CE  . LYS   A 1 189 ? -13.341 -18.529 11.229  1.00 41.85 ? 882  LYS   A CE  1 
ATOM   1314 N NZ  . LYS   A 1 189 ? -13.009 -17.069 11.274  1.00 44.28 ? 882  LYS   A NZ  1 
ATOM   1315 N N   . TRP   A 1 190 ? -19.931 -21.878 11.794  1.00 25.54 ? 883  TRP   A N   1 
ATOM   1316 C CA  . TRP   A 1 190 ? -21.304 -21.819 12.304  1.00 25.74 ? 883  TRP   A CA  1 
ATOM   1317 C C   . TRP   A 1 190 ? -21.921 -23.198 12.462  1.00 26.24 ? 883  TRP   A C   1 
ATOM   1318 O O   . TRP   A 1 190 ? -22.929 -23.324 13.151  1.00 26.54 ? 883  TRP   A O   1 
ATOM   1319 C CB  . TRP   A 1 190 ? -22.217 -21.010 11.373  1.00 25.50 ? 883  TRP   A CB  1 
ATOM   1320 C CG  . TRP   A 1 190 ? -22.174 -19.536 11.599  1.00 25.75 ? 883  TRP   A CG  1 
ATOM   1321 C CD1 . TRP   A 1 190 ? -23.057 -18.785 12.319  1.00 26.38 ? 883  TRP   A CD1 1 
ATOM   1322 C CD2 . TRP   A 1 190 ? -21.198 -18.625 11.080  1.00 25.87 ? 883  TRP   A CD2 1 
ATOM   1323 N NE1 . TRP   A 1 190 ? -22.699 -17.458 12.266  1.00 26.63 ? 883  TRP   A NE1 1 
ATOM   1324 C CE2 . TRP   A 1 190 ? -21.544 -17.336 11.533  1.00 26.54 ? 883  TRP   A CE2 1 
ATOM   1325 C CE3 . TRP   A 1 190 ? -20.074 -18.771 10.255  1.00 26.46 ? 883  TRP   A CE3 1 
ATOM   1326 C CZ2 . TRP   A 1 190 ? -20.799 -16.204 11.193  1.00 27.26 ? 883  TRP   A CZ2 1 
ATOM   1327 C CZ3 . TRP   A 1 190 ? -19.329 -17.654 9.938   1.00 27.35 ? 883  TRP   A CZ3 1 
ATOM   1328 C CH2 . TRP   A 1 190 ? -19.692 -16.388 10.405  1.00 27.47 ? 883  TRP   A CH2 1 
ATOM   1329 N N   . MET   A 1 191 ? -21.386 -24.217 11.775  1.00 26.22 ? 884  MET   A N   1 
ATOM   1330 C CA  . MET   A 1 191 ? -21.964 -25.553 11.825  1.00 26.39 ? 884  MET   A CA  1 
ATOM   1331 C C   . MET   A 1 191 ? -21.669 -26.300 13.117  1.00 25.80 ? 884  MET   A C   1 
ATOM   1332 O O   . MET   A 1 191 ? -20.625 -26.100 13.744  1.00 25.31 ? 884  MET   A O   1 
ATOM   1333 C CB  . MET   A 1 191 ? -21.501 -26.394 10.623  1.00 27.08 ? 884  MET   A CB  1 
ATOM   1334 C CG  . MET   A 1 191 ? -21.722 -25.733 9.296   1.00 29.54 ? 884  MET   A CG  1 
ATOM   1335 S SD  . MET   A 1 191 ? -20.486 -26.263 8.081   1.00 35.85 ? 884  MET   A SD  1 
ATOM   1336 C CE  . MET   A 1 191 ? -20.901 -27.949 7.906   1.00 34.44 ? 884  MET   A CE  1 
ATOM   1337 N N   . ALA   A 1 192 ? -22.591 -27.189 13.487  1.00 25.82 ? 885  ALA   A N   1 
ATOM   1338 C CA  . ALA   A 1 192 ? -22.396 -28.074 14.623  1.00 26.71 ? 885  ALA   A CA  1 
ATOM   1339 C C   . ALA   A 1 192 ? -21.348 -29.108 14.216  1.00 27.57 ? 885  ALA   A C   1 
ATOM   1340 O O   . ALA   A 1 192 ? -21.225 -29.418 13.023  1.00 27.95 ? 885  ALA   A O   1 
ATOM   1341 C CB  . ALA   A 1 192 ? -23.699 -28.763 14.980  1.00 26.84 ? 885  ALA   A CB  1 
ATOM   1342 N N   . LEU   A 1 193 ? -20.598 -29.655 15.183  1.00 27.66 ? 886  LEU   A N   1 
ATOM   1343 C CA  . LEU   A 1 193 ? -19.539 -30.608 14.863  1.00 28.57 ? 886  LEU   A CA  1 
ATOM   1344 C C   . LEU   A 1 193 ? -19.987 -31.795 13.990  1.00 30.03 ? 886  LEU   A C   1 
ATOM   1345 O O   . LEU   A 1 193 ? -19.240 -32.174 13.091  1.00 30.38 ? 886  LEU   A O   1 
ATOM   1346 C CB  . LEU   A 1 193 ? -18.808 -31.098 16.109  1.00 28.59 ? 886  LEU   A CB  1 
ATOM   1347 C CG  . LEU   A 1 193 ? -17.372 -31.555 15.876  1.00 29.87 ? 886  LEU   A CG  1 
ATOM   1348 C CD1 . LEU   A 1 193 ? -16.520 -30.448 15.270  1.00 30.40 ? 886  LEU   A CD1 1 
ATOM   1349 C CD2 . LEU   A 1 193 ? -16.748 -32.057 17.152  1.00 30.50 ? 886  LEU   A CD2 1 
ATOM   1350 N N   . GLU   A 1 194 ? -21.208 -32.332 14.184  1.00 30.50 ? 887  GLU   A N   1 
ATOM   1351 C CA  . GLU   A 1 194 ? -21.687 -33.439 13.348  1.00 31.11 ? 887  GLU   A CA  1 
ATOM   1352 C C   . GLU   A 1 194 ? -21.866 -33.021 11.899  1.00 32.11 ? 887  GLU   A C   1 
ATOM   1353 O O   . GLU   A 1 194 ? -21.636 -33.825 10.997  1.00 32.78 ? 887  GLU   A O   1 
ATOM   1354 C CB  . GLU   A 1 194 ? -22.975 -34.063 13.902  1.00 32.78 ? 887  GLU   A CB  1 
ATOM   1355 C CG  . GLU   A 1 194 ? -24.205 -33.180 13.820  1.00 36.45 ? 887  GLU   A CG  1 
ATOM   1356 C CD  . GLU   A 1 194 ? -24.482 -32.357 15.059  1.00 42.32 ? 887  GLU   A CD  1 
ATOM   1357 O OE1 . GLU   A 1 194 ? -23.518 -32.026 15.787  1.00 42.80 ? 887  GLU   A OE1 1 
ATOM   1358 O OE2 . GLU   A 1 194 ? -25.668 -32.042 15.305  1.00 44.93 ? 887  GLU   A OE2 1 
ATOM   1359 N N   . SER   A 1 195 ? -22.251 -31.767 11.664  1.00 32.16 ? 888  SER   A N   1 
ATOM   1360 C CA  . SER   A 1 195 ? -22.420 -31.257 10.310  1.00 32.64 ? 888  SER   A CA  1 
ATOM   1361 C C   . SER   A 1 195 ? -21.051 -31.081 9.658   1.00 32.89 ? 888  SER   A C   1 
ATOM   1362 O O   . SER   A 1 195 ? -20.905 -31.380 8.491   1.00 32.96 ? 888  SER   A O   1 
ATOM   1363 C CB  . SER   A 1 195 ? -23.176 -29.934 10.332  1.00 34.07 ? 888  SER   A CB  1 
ATOM   1364 O OG  . SER   A 1 195 ? -24.314 -30.013 11.177  1.00 36.35 ? 888  SER   A OG  1 
ATOM   1365 N N   . ILE   A 1 196 ? -20.041 -30.632 10.411  1.00 33.09 ? 889  ILE   A N   1 
ATOM   1366 C CA  . ILE   A 1 196 ? -18.689 -30.463 9.882   1.00 33.69 ? 889  ILE   A CA  1 
ATOM   1367 C C   . ILE   A 1 196 ? -18.037 -31.823 9.590   1.00 34.41 ? 889  ILE   A C   1 
ATOM   1368 O O   . ILE   A 1 196 ? -17.500 -32.027 8.504   1.00 34.39 ? 889  ILE   A O   1 
ATOM   1369 C CB  . ILE   A 1 196 ? -17.807 -29.635 10.856  1.00 33.96 ? 889  ILE   A CB  1 
ATOM   1370 C CG1 . ILE   A 1 196 ? -18.505 -28.353 11.309  1.00 34.99 ? 889  ILE   A CG1 1 
ATOM   1371 C CG2 . ILE   A 1 196 ? -16.445 -29.336 10.239  1.00 34.36 ? 889  ILE   A CG2 1 
ATOM   1372 C CD1 . ILE   A 1 196 ? -17.806 -27.635 12.456  1.00 36.51 ? 889  ILE   A CD1 1 
ATOM   1373 N N   . LEU   A 1 197 ? -18.079 -32.749 10.562  1.00 34.82 ? 890  LEU   A N   1 
ATOM   1374 C CA  . LEU   A 1 197 ? -17.438 -34.053 10.447  1.00 35.66 ? 890  LEU   A CA  1 
ATOM   1375 C C   . LEU   A 1 197 ? -18.153 -35.041 9.542   1.00 37.00 ? 890  LEU   A C   1 
ATOM   1376 O O   . LEU   A 1 197 ? -17.501 -35.619 8.674   1.00 37.24 ? 890  LEU   A O   1 
ATOM   1377 C CB  . LEU   A 1 197 ? -17.208 -34.687 11.826  1.00 35.57 ? 890  LEU   A CB  1 
ATOM   1378 C CG  . LEU   A 1 197 ? -16.370 -33.923 12.849  1.00 36.39 ? 890  LEU   A CG  1 
ATOM   1379 C CD1 . LEU   A 1 197 ? -16.174 -34.752 14.070  1.00 36.47 ? 890  LEU   A CD1 1 
ATOM   1380 C CD2 . LEU   A 1 197 ? -15.009 -33.563 12.300  1.00 37.08 ? 890  LEU   A CD2 1 
ATOM   1381 N N   . HIS   A 1 198 ? -19.462 -35.274 9.749   1.00 37.75 ? 891  HIS   A N   1 
ATOM   1382 C CA  . HIS   A 1 198 ? -20.166 -36.264 8.948   1.00 39.19 ? 891  HIS   A CA  1 
ATOM   1383 C C   . HIS   A 1 198 ? -21.398 -35.742 8.230   1.00 40.04 ? 891  HIS   A C   1 
ATOM   1384 O O   . HIS   A 1 198 ? -22.298 -36.526 7.944   1.00 40.45 ? 891  HIS   A O   1 
ATOM   1385 C CB  . HIS   A 1 198 ? -20.505 -37.486 9.790   1.00 40.94 ? 891  HIS   A CB  1 
ATOM   1386 C CG  . HIS   A 1 198 ? -19.295 -38.159 10.358  1.00 45.17 ? 891  HIS   A CG  1 
ATOM   1387 N ND1 . HIS   A 1 198 ? -19.250 -38.575 11.681  1.00 47.48 ? 891  HIS   A ND1 1 
ATOM   1388 C CD2 . HIS   A 1 198 ? -18.112 -38.458 9.766   1.00 46.80 ? 891  HIS   A CD2 1 
ATOM   1389 C CE1 . HIS   A 1 198 ? -18.053 -39.120 11.848  1.00 48.17 ? 891  HIS   A CE1 1 
ATOM   1390 N NE2 . HIS   A 1 198 ? -17.329 -39.068 10.726  1.00 48.11 ? 891  HIS   A NE2 1 
ATOM   1391 N N   . ARG   A 1 199 ? -21.416 -34.438 7.889   1.00 40.17 ? 892  ARG   A N   1 
ATOM   1392 C CA  . ARG   A 1 199 ? -22.493 -33.758 7.153   1.00 40.71 ? 892  ARG   A CA  1 
ATOM   1393 C C   . ARG   A 1 199 ? -23.897 -34.068 7.658   1.00 39.92 ? 892  ARG   A C   1 
ATOM   1394 O O   . ARG   A 1 199 ? -24.846 -34.133 6.875   1.00 39.46 ? 892  ARG   A O   1 
ATOM   1395 C CB  . ARG   A 1 199 ? -22.390 -34.013 5.648   1.00 43.76 ? 892  ARG   A CB  1 
ATOM   1396 C CG  . ARG   A 1 199 ? -21.420 -33.072 4.920   1.00 49.72 ? 892  ARG   A CG  1 
ATOM   1397 C CD  . ARG   A 1 199 ? -21.800 -31.598 5.051   1.00 54.90 ? 892  ARG   A CD  1 
ATOM   1398 N NE  . ARG   A 1 199 ? -20.815 -30.699 4.440   1.00 59.24 ? 892  ARG   A NE  1 
ATOM   1399 C CZ  . ARG   A 1 199 ? -19.710 -30.267 5.047   1.00 61.93 ? 892  ARG   A CZ  1 
ATOM   1400 N NH1 . ARG   A 1 199 ? -19.414 -30.675 6.274   1.00 60.92 ? 892  ARG   A NH1 1 
ATOM   1401 N NH2 . ARG   A 1 199 ? -18.876 -29.452 4.416   1.00 62.74 ? 892  ARG   A NH2 1 
ATOM   1402 N N   . ILE   A 1 200 ? -24.027 -34.235 8.979   1.00 39.51 ? 893  ILE   A N   1 
ATOM   1403 C CA  . ILE   A 1 200 ? -25.305 -34.543 9.609   1.00 39.31 ? 893  ILE   A CA  1 
ATOM   1404 C C   . ILE   A 1 200 ? -26.014 -33.242 9.996   1.00 38.87 ? 893  ILE   A C   1 
ATOM   1405 O O   . ILE   A 1 200 ? -25.535 -32.493 10.851  1.00 38.53 ? 893  ILE   A O   1 
ATOM   1406 C CB  . ILE   A 1 200 ? -25.149 -35.493 10.829  1.00 39.75 ? 893  ILE   A CB  1 
ATOM   1407 C CG1 . ILE   A 1 200 ? -24.126 -36.619 10.583  1.00 40.53 ? 893  ILE   A CG1 1 
ATOM   1408 C CG2 . ILE   A 1 200 ? -26.501 -36.056 11.258  1.00 40.28 ? 893  ILE   A CG2 1 
ATOM   1409 C CD1 . ILE   A 1 200 ? -23.522 -37.196 11.869  1.00 41.69 ? 893  ILE   A CD1 1 
ATOM   1410 N N   . TYR   A 1 201 ? -27.139 -32.957 9.336   1.00 38.54 ? 894  TYR   A N   1 
ATOM   1411 C CA  . TYR   A 1 201 ? -27.919 -31.766 9.639   1.00 38.56 ? 894  TYR   A CA  1 
ATOM   1412 C C   . TYR   A 1 201 ? -29.236 -32.224 10.227  1.00 38.51 ? 894  TYR   A C   1 
ATOM   1413 O O   . TYR   A 1 201 ? -30.013 -32.917 9.562   1.00 38.72 ? 894  TYR   A O   1 
ATOM   1414 C CB  . TYR   A 1 201 ? -28.181 -30.913 8.390   1.00 38.48 ? 894  TYR   A CB  1 
ATOM   1415 C CG  . TYR   A 1 201 ? -26.955 -30.293 7.758   1.00 38.92 ? 894  TYR   A CG  1 
ATOM   1416 C CD1 . TYR   A 1 201 ? -26.194 -30.997 6.834   1.00 39.77 ? 894  TYR   A CD1 1 
ATOM   1417 C CD2 . TYR   A 1 201 ? -26.598 -28.982 8.028   1.00 39.54 ? 894  TYR   A CD2 1 
ATOM   1418 C CE1 . TYR   A 1 201 ? -25.086 -30.422 6.223   1.00 40.72 ? 894  TYR   A CE1 1 
ATOM   1419 C CE2 . TYR   A 1 201 ? -25.502 -28.391 7.412   1.00 40.51 ? 894  TYR   A CE2 1 
ATOM   1420 C CZ  . TYR   A 1 201 ? -24.743 -29.114 6.512   1.00 41.56 ? 894  TYR   A CZ  1 
ATOM   1421 O OH  . TYR   A 1 201 ? -23.659 -28.526 5.899   1.00 42.94 ? 894  TYR   A OH  1 
ATOM   1422 N N   . THR   A 1 202 ? -29.444 -31.895 11.502  1.00 38.20 ? 895  THR   A N   1 
ATOM   1423 C CA  . THR   A 1 202 ? -30.637 -32.203 12.290  1.00 38.29 ? 895  THR   A CA  1 
ATOM   1424 C C   . THR   A 1 202 ? -31.202 -30.887 12.882  1.00 38.18 ? 895  THR   A C   1 
ATOM   1425 O O   . THR   A 1 202 ? -30.557 -29.837 12.749  1.00 38.58 ? 895  THR   A O   1 
ATOM   1426 C CB  . THR   A 1 202 ? -30.259 -33.203 13.405  1.00 39.45 ? 895  THR   A CB  1 
ATOM   1427 O OG1 . THR   A 1 202 ? -29.215 -32.640 14.201  1.00 39.99 ? 895  THR   A OG1 1 
ATOM   1428 C CG2 . THR   A 1 202 ? -29.822 -34.554 12.853  1.00 40.03 ? 895  THR   A CG2 1 
ATOM   1429 N N   . HIS   A 1 203 ? -32.380 -30.925 13.547  1.00 37.33 ? 896  HIS   A N   1 
ATOM   1430 C CA  . HIS   A 1 203 ? -32.910 -29.716 14.180  1.00 37.04 ? 896  HIS   A CA  1 
ATOM   1431 C C   . HIS   A 1 203 ? -31.979 -29.231 15.287  1.00 36.81 ? 896  HIS   A C   1 
ATOM   1432 O O   . HIS   A 1 203 ? -31.879 -28.032 15.507  1.00 36.90 ? 896  HIS   A O   1 
ATOM   1433 C CB  . HIS   A 1 203 ? -34.323 -29.930 14.711  1.00 37.70 ? 896  HIS   A CB  1 
ATOM   1434 C CG  . HIS   A 1 203 ? -35.361 -29.960 13.634  1.00 39.65 ? 896  HIS   A CG  1 
ATOM   1435 N ND1 . HIS   A 1 203 ? -35.713 -31.140 13.003  1.00 41.51 ? 896  HIS   A ND1 1 
ATOM   1436 C CD2 . HIS   A 1 203 ? -36.099 -28.952 13.119  1.00 40.62 ? 896  HIS   A CD2 1 
ATOM   1437 C CE1 . HIS   A 1 203 ? -36.656 -30.813 12.137  1.00 42.02 ? 896  HIS   A CE1 1 
ATOM   1438 N NE2 . HIS   A 1 203 ? -36.923 -29.508 12.174  1.00 41.89 ? 896  HIS   A NE2 1 
ATOM   1439 N N   . GLN   A 1 204 ? -31.257 -30.161 15.940  1.00 36.45 ? 897  GLN   A N   1 
ATOM   1440 C CA  . GLN   A 1 204 ? -30.276 -29.877 16.979  1.00 36.42 ? 897  GLN   A CA  1 
ATOM   1441 C C   . GLN   A 1 204 ? -28.977 -29.285 16.434  1.00 36.32 ? 897  GLN   A C   1 
ATOM   1442 O O   . GLN   A 1 204 ? -28.283 -28.572 17.159  1.00 36.59 ? 897  GLN   A O   1 
ATOM   1443 C CB  . GLN   A 1 204 ? -30.022 -31.124 17.819  1.00 37.70 ? 897  GLN   A CB  1 
ATOM   1444 C CG  . GLN   A 1 204 ? -31.296 -31.635 18.485  1.00 40.49 ? 897  GLN   A CG  1 
ATOM   1445 C CD  . GLN   A 1 204 ? -31.919 -30.606 19.398  1.00 43.38 ? 897  GLN   A CD  1 
ATOM   1446 O OE1 . GLN   A 1 204 ? -31.336 -30.219 20.418  1.00 45.15 ? 897  GLN   A OE1 1 
ATOM   1447 N NE2 . GLN   A 1 204 ? -33.109 -30.133 19.040  1.00 42.88 ? 897  GLN   A NE2 1 
ATOM   1448 N N   . SER   A 1 205 ? -28.661 -29.536 15.153  1.00 35.70 ? 898  SER   A N   1 
ATOM   1449 C CA  . SER   A 1 205 ? -27.500 -28.913 14.530  1.00 35.13 ? 898  SER   A CA  1 
ATOM   1450 C C   . SER   A 1 205 ? -27.797 -27.425 14.320  1.00 34.25 ? 898  SER   A C   1 
ATOM   1451 O O   . SER   A 1 205 ? -26.886 -26.619 14.462  1.00 34.71 ? 898  SER   A O   1 
ATOM   1452 C CB  . SER   A 1 205 ? -27.132 -29.601 13.222  1.00 36.48 ? 898  SER   A CB  1 
ATOM   1453 O OG  . SER   A 1 205 ? -28.129 -29.394 12.237  1.00 39.28 ? 898  SER   A OG  1 
ATOM   1454 N N   . ASP   A 1 206 ? -29.078 -27.050 14.061  1.00 33.03 ? 899  ASP   A N   1 
ATOM   1455 C CA  . ASP   A 1 206 ? -29.507 -25.653 13.925  1.00 32.50 ? 899  ASP   A CA  1 
ATOM   1456 C C   . ASP   A 1 206 ? -29.443 -24.896 15.273  1.00 31.61 ? 899  ASP   A C   1 
ATOM   1457 O O   . ASP   A 1 206 ? -29.313 -23.670 15.285  1.00 31.77 ? 899  ASP   A O   1 
ATOM   1458 C CB  . ASP   A 1 206 ? -30.914 -25.566 13.319  1.00 34.22 ? 899  ASP   A CB  1 
ATOM   1459 C CG  . ASP   A 1 206 ? -30.965 -25.519 11.793  1.00 39.43 ? 899  ASP   A CG  1 
ATOM   1460 O OD1 . ASP   A 1 206 ? -29.889 -25.335 11.152  1.00 39.51 ? 899  ASP   A OD1 1 
ATOM   1461 O OD2 . ASP   A 1 206 ? -32.073 -25.653 11.238  1.00 42.15 ? 899  ASP   A OD2 1 
ATOM   1462 N N   . VAL   A 1 207 ? -29.522 -25.619 16.400  1.00 30.36 ? 900  VAL   A N   1 
ATOM   1463 C CA  . VAL   A 1 207 ? -29.381 -25.001 17.712  1.00 29.85 ? 900  VAL   A CA  1 
ATOM   1464 C C   . VAL   A 1 207 ? -27.912 -24.580 17.931  1.00 29.17 ? 900  VAL   A C   1 
ATOM   1465 O O   . VAL   A 1 207 ? -27.666 -23.576 18.609  1.00 29.00 ? 900  VAL   A O   1 
ATOM   1466 C CB  . VAL   A 1 207 ? -29.924 -25.882 18.857  1.00 30.49 ? 900  VAL   A CB  1 
ATOM   1467 C CG1 . VAL   A 1 207 ? -29.883 -25.137 20.181  1.00 31.01 ? 900  VAL   A CG1 1 
ATOM   1468 C CG2 . VAL   A 1 207 ? -31.339 -26.349 18.558  1.00 30.89 ? 900  VAL   A CG2 1 
ATOM   1469 N N   . TRP   A 1 208 ? -26.936 -25.290 17.304  1.00 28.36 ? 901  TRP   A N   1 
ATOM   1470 C CA  . TRP   A 1 208 ? -25.539 -24.875 17.401  1.00 28.14 ? 901  TRP   A CA  1 
ATOM   1471 C C   . TRP   A 1 208 ? -25.378 -23.552 16.652  1.00 28.09 ? 901  TRP   A C   1 
ATOM   1472 O O   . TRP   A 1 208 ? -24.790 -22.612 17.179  1.00 28.55 ? 901  TRP   A O   1 
ATOM   1473 C CB  . TRP   A 1 208 ? -24.590 -25.929 16.825  1.00 27.73 ? 901  TRP   A CB  1 
ATOM   1474 C CG  . TRP   A 1 208 ? -23.141 -25.585 17.023  1.00 27.99 ? 901  TRP   A CG  1 
ATOM   1475 C CD1 . TRP   A 1 208 ? -22.500 -24.446 16.621  1.00 28.96 ? 901  TRP   A CD1 1 
ATOM   1476 C CD2 . TRP   A 1 208 ? -22.154 -26.388 17.684  1.00 27.81 ? 901  TRP   A CD2 1 
ATOM   1477 N NE1 . TRP   A 1 208 ? -21.184 -24.481 17.015  1.00 29.25 ? 901  TRP   A NE1 1 
ATOM   1478 C CE2 . TRP   A 1 208 ? -20.938 -25.679 17.639  1.00 28.60 ? 901  TRP   A CE2 1 
ATOM   1479 C CE3 . TRP   A 1 208 ? -22.163 -27.672 18.240  1.00 27.95 ? 901  TRP   A CE3 1 
ATOM   1480 C CZ2 . TRP   A 1 208 ? -19.758 -26.197 18.161  1.00 28.72 ? 901  TRP   A CZ2 1 
ATOM   1481 C CZ3 . TRP   A 1 208 ? -20.984 -28.194 18.721  1.00 28.52 ? 901  TRP   A CZ3 1 
ATOM   1482 C CH2 . TRP   A 1 208 ? -19.801 -27.458 18.684  1.00 28.63 ? 901  TRP   A CH2 1 
ATOM   1483 N N   . SER   A 1 209 ? -25.960 -23.457 15.458  1.00 27.48 ? 902  SER   A N   1 
ATOM   1484 C CA  . SER   A 1 209 ? -25.916 -22.239 14.668  1.00 27.38 ? 902  SER   A CA  1 
ATOM   1485 C C   . SER   A 1 209 ? -26.609 -21.090 15.404  1.00 26.33 ? 902  SER   A C   1 
ATOM   1486 O O   . SER   A 1 209 ? -26.106 -19.973 15.399  1.00 26.34 ? 902  SER   A O   1 
ATOM   1487 C CB  . SER   A 1 209 ? -26.546 -22.471 13.299  1.00 29.00 ? 902  SER   A CB  1 
ATOM   1488 O OG  . SER   A 1 209 ? -25.786 -23.402 12.546  1.00 31.68 ? 902  SER   A OG  1 
ATOM   1489 N N   . TYR   A 1 210 ? -27.718 -21.374 16.088  1.00 25.17 ? 903  TYR   A N   1 
ATOM   1490 C CA  . TYR   A 1 210 ? -28.424 -20.363 16.858  1.00 24.91 ? 903  TYR   A CA  1 
ATOM   1491 C C   . TYR   A 1 210 ? -27.531 -19.790 17.967  1.00 24.55 ? 903  TYR   A C   1 
ATOM   1492 O O   . TYR   A 1 210 ? -27.583 -18.594 18.228  1.00 24.76 ? 903  TYR   A O   1 
ATOM   1493 C CB  . TYR   A 1 210 ? -29.727 -20.936 17.429  1.00 24.93 ? 903  TYR   A CB  1 
ATOM   1494 C CG  . TYR   A 1 210 ? -30.403 -20.028 18.433  1.00 25.34 ? 903  TYR   A CG  1 
ATOM   1495 C CD1 . TYR   A 1 210 ? -31.309 -19.064 18.025  1.00 26.09 ? 903  TYR   A CD1 1 
ATOM   1496 C CD2 . TYR   A 1 210 ? -30.131 -20.134 19.790  1.00 26.14 ? 903  TYR   A CD2 1 
ATOM   1497 C CE1 . TYR   A 1 210 ? -31.924 -18.222 18.941  1.00 26.94 ? 903  TYR   A CE1 1 
ATOM   1498 C CE2 . TYR   A 1 210 ? -30.716 -19.276 20.712  1.00 26.84 ? 903  TYR   A CE2 1 
ATOM   1499 C CZ  . TYR   A 1 210 ? -31.627 -18.333 20.285  1.00 27.45 ? 903  TYR   A CZ  1 
ATOM   1500 O OH  . TYR   A 1 210 ? -32.221 -17.497 21.193  1.00 28.23 ? 903  TYR   A OH  1 
ATOM   1501 N N   . GLY   A 1 211 ? -26.733 -20.643 18.600  1.00 23.79 ? 904  GLY   A N   1 
ATOM   1502 C CA  . GLY   A 1 211 ? -25.810 -20.221 19.642  1.00 23.46 ? 904  GLY   A CA  1 
ATOM   1503 C C   . GLY   A 1 211 ? -24.743 -19.309 19.078  1.00 22.81 ? 904  GLY   A C   1 
ATOM   1504 O O   . GLY   A 1 211 ? -24.468 -18.251 19.643  1.00 22.63 ? 904  GLY   A O   1 
ATOM   1505 N N   . VAL   A 1 212 ? -24.192 -19.678 17.914  1.00 22.43 ? 905  VAL   A N   1 
ATOM   1506 C CA  . VAL   A 1 212 ? -23.186 -18.890 17.208  1.00 22.59 ? 905  VAL   A CA  1 
ATOM   1507 C C   . VAL   A 1 212 ? -23.789 -17.526 16.837  1.00 23.26 ? 905  VAL   A C   1 
ATOM   1508 O O   . VAL   A 1 212 ? -23.186 -16.495 17.127  1.00 23.37 ? 905  VAL   A O   1 
ATOM   1509 C CB  . VAL   A 1 212 ? -22.679 -19.644 15.956  1.00 22.94 ? 905  VAL   A CB  1 
ATOM   1510 C CG1 . VAL   A 1 212 ? -21.784 -18.751 15.102  1.00 23.55 ? 905  VAL   A CG1 1 
ATOM   1511 C CG2 . VAL   A 1 212 ? -21.965 -20.946 16.328  1.00 22.97 ? 905  VAL   A CG2 1 
ATOM   1512 N N   . THR   A 1 213 ? -25.029 -17.534 16.297  1.00 23.45 ? 906  THR   A N   1 
ATOM   1513 C CA  . THR   A 1 213 ? -25.833 -16.363 15.912  1.00 24.06 ? 906  THR   A CA  1 
ATOM   1514 C C   . THR   A 1 213 ? -26.035 -15.434 17.107  1.00 25.13 ? 906  THR   A C   1 
ATOM   1515 O O   . THR   A 1 213 ? -25.905 -14.223 16.959  1.00 25.93 ? 906  THR   A O   1 
ATOM   1516 C CB  . THR   A 1 213 ? -27.215 -16.803 15.411  1.00 24.92 ? 906  THR   A CB  1 
ATOM   1517 O OG1 . THR   A 1 213 ? -27.093 -17.887 14.495  1.00 26.33 ? 906  THR   A OG1 1 
ATOM   1518 C CG2 . THR   A 1 213 ? -28.010 -15.661 14.816  1.00 24.89 ? 906  THR   A CG2 1 
ATOM   1519 N N   . VAL   A 1 214 ? -26.347 -15.993 18.288  1.00 24.86 ? 907  VAL   A N   1 
ATOM   1520 C CA  . VAL   A 1 214 ? -26.518 -15.204 19.490  1.00 25.27 ? 907  VAL   A CA  1 
ATOM   1521 C C   . VAL   A 1 214 ? -25.174 -14.628 19.898  1.00 25.59 ? 907  VAL   A C   1 
ATOM   1522 O O   . VAL   A 1 214 ? -25.104 -13.457 20.261  1.00 26.20 ? 907  VAL   A O   1 
ATOM   1523 C CB  . VAL   A 1 214 ? -27.208 -16.005 20.623  1.00 26.17 ? 907  VAL   A CB  1 
ATOM   1524 C CG1 . VAL   A 1 214 ? -27.033 -15.333 21.984  1.00 26.47 ? 907  VAL   A CG1 1 
ATOM   1525 C CG2 . VAL   A 1 214 ? -28.687 -16.202 20.315  1.00 26.86 ? 907  VAL   A CG2 1 
ATOM   1526 N N   . TRP   A 1 215 ? -24.095 -15.409 19.777  1.00 25.15 ? 908  TRP   A N   1 
ATOM   1527 C CA  . TRP   A 1 215 ? -22.759 -14.918 20.094  1.00 25.37 ? 908  TRP   A CA  1 
ATOM   1528 C C   . TRP   A 1 215 ? -22.383 -13.729 19.194  1.00 25.12 ? 908  TRP   A C   1 
ATOM   1529 O O   . TRP   A 1 215 ? -21.681 -12.830 19.645  1.00 25.18 ? 908  TRP   A O   1 
ATOM   1530 C CB  . TRP   A 1 215 ? -21.721 -16.050 20.010  1.00 25.32 ? 908  TRP   A CB  1 
ATOM   1531 C CG  . TRP   A 1 215 ? -20.332 -15.638 20.395  1.00 25.52 ? 908  TRP   A CG  1 
ATOM   1532 C CD1 . TRP   A 1 215 ? -19.772 -15.707 21.635  1.00 26.38 ? 908  TRP   A CD1 1 
ATOM   1533 C CD2 . TRP   A 1 215 ? -19.330 -15.085 19.529  1.00 25.34 ? 908  TRP   A CD2 1 
ATOM   1534 N NE1 . TRP   A 1 215 ? -18.479 -15.240 21.593  1.00 26.63 ? 908  TRP   A NE1 1 
ATOM   1535 C CE2 . TRP   A 1 215 ? -18.185 -14.849 20.311  1.00 26.18 ? 908  TRP   A CE2 1 
ATOM   1536 C CE3 . TRP   A 1 215 ? -19.297 -14.748 18.171  1.00 25.69 ? 908  TRP   A CE3 1 
ATOM   1537 C CZ2 . TRP   A 1 215 ? -17.016 -14.318 19.774  1.00 26.66 ? 908  TRP   A CZ2 1 
ATOM   1538 C CZ3 . TRP   A 1 215 ? -18.150 -14.190 17.651  1.00 26.35 ? 908  TRP   A CZ3 1 
ATOM   1539 C CH2 . TRP   A 1 215 ? -17.018 -14.004 18.439  1.00 26.59 ? 908  TRP   A CH2 1 
ATOM   1540 N N   . GLU   A 1 216 ? -22.875 -13.712 17.946  1.00 24.68 ? 909  GLU   A N   1 
ATOM   1541 C CA  . GLU   A 1 216 ? -22.633 -12.616 17.019  1.00 24.90 ? 909  GLU   A CA  1 
ATOM   1542 C C   . GLU   A 1 216 ? -23.317 -11.351 17.529  1.00 24.83 ? 909  GLU   A C   1 
ATOM   1543 O O   . GLU   A 1 216 ? -22.695 -10.297 17.507  1.00 25.09 ? 909  GLU   A O   1 
ATOM   1544 C CB  . GLU   A 1 216 ? -23.145 -12.946 15.603  1.00 27.12 ? 909  GLU   A CB  1 
ATOM   1545 C CG  . GLU   A 1 216 ? -22.480 -14.139 14.935  1.00 31.93 ? 909  GLU   A CG  1 
ATOM   1546 C CD  . GLU   A 1 216 ? -22.643 -14.192 13.425  1.00 38.52 ? 909  GLU   A CD  1 
ATOM   1547 O OE1 . GLU   A 1 216 ? -23.473 -14.997 12.938  1.00 39.08 ? 909  GLU   A OE1 1 
ATOM   1548 O OE2 . GLU   A 1 216 ? -21.935 -13.427 12.727  1.00 40.98 ? 909  GLU   A OE2 1 
ATOM   1549 N N   . LEU   A 1 217 ? -24.579 -11.447 18.013  1.00 24.31 ? 910  LEU   A N   1 
ATOM   1550 C CA  . LEU   A 1 217 ? -25.313 -10.270 18.499  1.00 24.37 ? 910  LEU   A CA  1 
ATOM   1551 C C   . LEU   A 1 217 ? -24.652 -9.715  19.755  1.00 25.67 ? 910  LEU   A C   1 
ATOM   1552 O O   . LEU   A 1 217 ? -24.425 -8.509  19.873  1.00 25.67 ? 910  LEU   A O   1 
ATOM   1553 C CB  . LEU   A 1 217 ? -26.804 -10.566 18.796  1.00 23.67 ? 910  LEU   A CB  1 
ATOM   1554 C CG  . LEU   A 1 217 ? -27.630 -11.447 17.855  1.00 24.12 ? 910  LEU   A CG  1 
ATOM   1555 C CD1 . LEU   A 1 217 ? -29.106 -11.333 18.193  1.00 24.12 ? 910  LEU   A CD1 1 
ATOM   1556 C CD2 . LEU   A 1 217 ? -27.417 -11.091 16.380  1.00 24.49 ? 910  LEU   A CD2 1 
ATOM   1557 N N   . MET   A 1 218 ? -24.308 -10.616 20.679  1.00 26.52 ? 911  MET   A N   1 
ATOM   1558 C CA  . MET   A 1 218 ? -23.675 -10.273 21.944  1.00 27.71 ? 911  MET   A CA  1 
ATOM   1559 C C   . MET   A 1 218 ? -22.219 -9.751  21.805  1.00 28.35 ? 911  MET   A C   1 
ATOM   1560 O O   . MET   A 1 218 ? -21.654 -9.237  22.780  1.00 28.57 ? 911  MET   A O   1 
ATOM   1561 C CB  . MET   A 1 218 ? -23.761 -11.465 22.904  1.00 28.80 ? 911  MET   A CB  1 
ATOM   1562 C CG  . MET   A 1 218 ? -25.178 -11.998 23.092  1.00 31.04 ? 911  MET   A CG  1 
ATOM   1563 S SD  . MET   A 1 218 ? -26.303 -10.810 23.862  1.00 32.71 ? 911  MET   A SD  1 
ATOM   1564 C CE  . MET   A 1 218 ? -27.744 -11.800 24.055  1.00 28.48 ? 911  MET   A CE  1 
ATOM   1565 N N   . THR   A 1 219 ? -21.621 -9.886  20.604  1.00 28.25 ? 912  THR   A N   1 
ATOM   1566 C CA  . THR   A 1 219 ? -20.275 -9.390  20.302  1.00 28.61 ? 912  THR   A CA  1 
ATOM   1567 C C   . THR   A 1 219 ? -20.281 -8.317  19.219  1.00 28.87 ? 912  THR   A C   1 
ATOM   1568 O O   . THR   A 1 219 ? -19.245 -8.084  18.603  1.00 28.71 ? 912  THR   A O   1 
ATOM   1569 C CB  . THR   A 1 219 ? -19.337 -10.526 19.893  1.00 30.09 ? 912  THR   A CB  1 
ATOM   1570 O OG1 . THR   A 1 219 ? -19.966 -11.303 18.877  1.00 31.23 ? 912  THR   A OG1 1 
ATOM   1571 C CG2 . THR   A 1 219 ? -18.931 -11.413 21.069  1.00 30.50 ? 912  THR   A CG2 1 
ATOM   1572 N N   . PHE   A 1 220 ? -21.446 -7.682  18.978  1.00 29.27 ? 913  PHE   A N   1 
ATOM   1573 C CA  . PHE   A 1 220 ? -21.684 -6.613  18.012  1.00 30.08 ? 913  PHE   A CA  1 
ATOM   1574 C C   . PHE   A 1 220 ? -21.142 -6.912  16.628  1.00 31.26 ? 913  PHE   A C   1 
ATOM   1575 O O   . PHE   A 1 220 ? -20.547 -6.057  15.963  1.00 31.28 ? 913  PHE   A O   1 
ATOM   1576 C CB  . PHE   A 1 220 ? -21.195 -5.269  18.539  1.00 29.79 ? 913  PHE   A CB  1 
ATOM   1577 C CG  . PHE   A 1 220 ? -21.963 -4.927  19.785  1.00 30.26 ? 913  PHE   A CG  1 
ATOM   1578 C CD1 . PHE   A 1 220 ? -23.329 -4.724  19.737  1.00 31.03 ? 913  PHE   A CD1 1 
ATOM   1579 C CD2 . PHE   A 1 220 ? -21.340 -4.911  21.018  1.00 30.96 ? 913  PHE   A CD2 1 
ATOM   1580 C CE1 . PHE   A 1 220 ? -24.048 -4.463  20.894  1.00 31.84 ? 913  PHE   A CE1 1 
ATOM   1581 C CE2 . PHE   A 1 220 ? -22.060 -4.638  22.172  1.00 31.65 ? 913  PHE   A CE2 1 
ATOM   1582 C CZ  . PHE   A 1 220 ? -23.410 -4.418  22.105  1.00 31.48 ? 913  PHE   A CZ  1 
ATOM   1583 N N   . GLY   A 1 221 ? -21.389 -8.140  16.209  1.00 32.04 ? 914  GLY   A N   1 
ATOM   1584 C CA  . GLY   A 1 221 ? -21.051 -8.628  14.885  1.00 33.08 ? 914  GLY   A CA  1 
ATOM   1585 C C   . GLY   A 1 221 ? -19.654 -9.168  14.693  1.00 33.84 ? 914  GLY   A C   1 
ATOM   1586 O O   . GLY   A 1 221 ? -19.246 -9.355  13.547  1.00 34.38 ? 914  GLY   A O   1 
ATOM   1587 N N   . SER   A 1 222 ? -18.910 -9.472  15.779  1.00 33.65 ? 915  SER   A N   1 
ATOM   1588 C CA  . SER   A 1 222 ? -17.549 -10.006 15.621  1.00 34.04 ? 915  SER   A CA  1 
ATOM   1589 C C   . SER   A 1 222 ? -17.554 -11.315 14.818  1.00 34.53 ? 915  SER   A C   1 
ATOM   1590 O O   . SER   A 1 222 ? -18.589 -11.986 14.754  1.00 34.77 ? 915  SER   A O   1 
ATOM   1591 C CB  . SER   A 1 222 ? -16.857 -10.175 16.971  1.00 35.27 ? 915  SER   A CB  1 
ATOM   1592 O OG  . SER   A 1 222 ? -16.530 -8.927  17.566  1.00 37.00 ? 915  SER   A OG  1 
ATOM   1593 N N   . LYS   A 1 223 ? -16.461 -11.611 14.109  1.00 34.66 ? 916  LYS   A N   1 
ATOM   1594 C CA  . LYS   A 1 223 ? -16.400 -12.831 13.308  1.00 35.27 ? 916  LYS   A CA  1 
ATOM   1595 C C   . LYS   A 1 223 ? -15.948 -14.012 14.173  1.00 36.01 ? 916  LYS   A C   1 
ATOM   1596 O O   . LYS   A 1 223 ? -14.884 -13.971 14.790  1.00 36.14 ? 916  LYS   A O   1 
ATOM   1597 C CB  . LYS   A 1 223 ? -15.573 -12.627 12.023  1.00 36.72 ? 916  LYS   A CB  1 
ATOM   1598 C CG  . LYS   A 1 223 ? -16.359 -11.824 10.981  1.00 39.83 ? 916  LYS   A CG  1 
ATOM   1599 C CD  . LYS   A 1 223 ? -15.639 -11.628 9.648   1.00 43.53 ? 916  LYS   A CD  1 
ATOM   1600 C CE  . LYS   A 1 223 ? -16.587 -11.179 8.545   1.00 45.76 ? 916  LYS   A CE  1 
ATOM   1601 N NZ  . LYS   A 1 223 ? -15.883 -10.444 7.465   1.00 46.34 ? 916  LYS   A NZ  1 
ATOM   1602 N N   . PRO   A 1 224 ? -16.820 -15.021 14.334  1.00 36.37 ? 917  PRO   A N   1 
ATOM   1603 C CA  . PRO   A 1 224 ? -16.488 -16.151 15.209  1.00 37.11 ? 917  PRO   A CA  1 
ATOM   1604 C C   . PRO   A 1 224 ? -15.194 -16.842 14.853  1.00 38.65 ? 917  PRO   A C   1 
ATOM   1605 O O   . PRO   A 1 224 ? -14.949 -17.053 13.677  1.00 39.13 ? 917  PRO   A O   1 
ATOM   1606 C CB  . PRO   A 1 224 ? -17.680 -17.095 15.030  1.00 37.47 ? 917  PRO   A CB  1 
ATOM   1607 C CG  . PRO   A 1 224 ? -18.322 -16.682 13.775  1.00 37.69 ? 917  PRO   A CG  1 
ATOM   1608 C CD  . PRO   A 1 224 ? -18.141 -15.202 13.715  1.00 35.94 ? 917  PRO   A CD  1 
ATOM   1609 N N   . TYR   A 1 225 ? -14.363 -17.163 15.858  1.00 39.38 ? 918  TYR   A N   1 
ATOM   1610 C CA  . TYR   A 1 225 ? -13.075 -17.835 15.680  1.00 40.70 ? 918  TYR   A CA  1 
ATOM   1611 C C   . TYR   A 1 225 ? -12.150 -17.003 14.802  1.00 41.86 ? 918  TYR   A C   1 
ATOM   1612 O O   . TYR   A 1 225 ? -11.489 -17.535 13.899  1.00 41.76 ? 918  TYR   A O   1 
ATOM   1613 C CB  . TYR   A 1 225 ? -13.251 -19.255 15.112  1.00 40.89 ? 918  TYR   A CB  1 
ATOM   1614 C CG  . TYR   A 1 225 ? -14.275 -20.085 15.852  1.00 41.88 ? 918  TYR   A CG  1 
ATOM   1615 C CD1 . TYR   A 1 225 ? -14.009 -20.585 17.116  1.00 43.04 ? 918  TYR   A CD1 1 
ATOM   1616 C CD2 . TYR   A 1 225 ? -15.495 -20.394 15.274  1.00 42.83 ? 918  TYR   A CD2 1 
ATOM   1617 C CE1 . TYR   A 1 225 ? -14.941 -21.356 17.798  1.00 44.15 ? 918  TYR   A CE1 1 
ATOM   1618 C CE2 . TYR   A 1 225 ? -16.441 -21.154 15.950  1.00 43.91 ? 918  TYR   A CE2 1 
ATOM   1619 C CZ  . TYR   A 1 225 ? -16.158 -21.640 17.211  1.00 45.03 ? 918  TYR   A CZ  1 
ATOM   1620 O OH  . TYR   A 1 225 ? -17.088 -22.393 17.893  1.00 46.66 ? 918  TYR   A OH  1 
ATOM   1621 N N   . ASP   A 1 226 ? -12.124 -15.681 15.059  1.00 42.63 ? 919  ASP   A N   1 
ATOM   1622 C CA  . ASP   A 1 226 ? -11.311 -14.737 14.295  1.00 43.89 ? 919  ASP   A CA  1 
ATOM   1623 C C   . ASP   A 1 226 ? -9.839  -15.121 14.360  1.00 44.85 ? 919  ASP   A C   1 
ATOM   1624 O O   . ASP   A 1 226 ? -9.248  -15.172 15.437  1.00 45.10 ? 919  ASP   A O   1 
ATOM   1625 C CB  . ASP   A 1 226 ? -11.530 -13.291 14.778  1.00 45.67 ? 919  ASP   A CB  1 
ATOM   1626 C CG  . ASP   A 1 226 ? -11.021 -12.227 13.817  1.00 50.53 ? 919  ASP   A CG  1 
ATOM   1627 O OD1 . ASP   A 1 226 ? -11.030 -12.481 12.581  1.00 50.98 ? 919  ASP   A OD1 1 
ATOM   1628 O OD2 . ASP   A 1 226 ? -10.622 -11.138 14.295  1.00 52.70 ? 919  ASP   A OD2 1 
ATOM   1629 N N   . GLY   A 1 227 ? -9.293  -15.469 13.209  1.00 45.19 ? 920  GLY   A N   1 
ATOM   1630 C CA  . GLY   A 1 227 ? -7.908  -15.889 13.103  1.00 45.94 ? 920  GLY   A CA  1 
ATOM   1631 C C   . GLY   A 1 227 ? -7.825  -17.324 12.643  1.00 46.52 ? 920  GLY   A C   1 
ATOM   1632 O O   . GLY   A 1 227 ? -7.145  -17.631 11.659  1.00 46.89 ? 920  GLY   A O   1 
ATOM   1633 N N   . ILE   A 1 228 ? -8.574  -18.198 13.322  1.00 46.36 ? 921  ILE   A N   1 
ATOM   1634 C CA  . ILE   A 1 228 ? -8.588  -19.631 13.046  1.00 46.84 ? 921  ILE   A CA  1 
ATOM   1635 C C   . ILE   A 1 228 ? -9.138  -20.000 11.663  1.00 47.14 ? 921  ILE   A C   1 
ATOM   1636 O O   . ILE   A 1 228 ? -10.280 -19.682 11.342  1.00 47.41 ? 921  ILE   A O   1 
ATOM   1637 C CB  . ILE   A 1 228 ? -9.336  -20.382 14.168  1.00 47.27 ? 921  ILE   A CB  1 
ATOM   1638 C CG1 . ILE   A 1 228 ? -8.717  -20.075 15.525  1.00 48.54 ? 921  ILE   A CG1 1 
ATOM   1639 C CG2 . ILE   A 1 228 ? -9.342  -21.878 13.920  1.00 47.55 ? 921  ILE   A CG2 1 
ATOM   1640 C CD1 . ILE   A 1 228 ? -9.530  -19.145 16.363  1.00 50.23 ? 921  ILE   A CD1 1 
ATOM   1641 N N   . PRO   A 1 229 ? -8.348  -20.713 10.846  1.00 46.90 ? 922  PRO   A N   1 
ATOM   1642 C CA  . PRO   A 1 229 ? -8.859  -21.152 9.536   1.00 47.22 ? 922  PRO   A CA  1 
ATOM   1643 C C   . PRO   A 1 229 ? -10.052 -22.111 9.664   1.00 47.51 ? 922  PRO   A C   1 
ATOM   1644 O O   . PRO   A 1 229 ? -10.230 -22.740 10.706  1.00 47.74 ? 922  PRO   A O   1 
ATOM   1645 C CB  . PRO   A 1 229 ? -7.646  -21.843 8.889   1.00 47.90 ? 922  PRO   A CB  1 
ATOM   1646 C CG  . PRO   A 1 229 ? -6.453  -21.403 9.704   1.00 48.20 ? 922  PRO   A CG  1 
ATOM   1647 C CD  . PRO   A 1 229 ? -6.974  -21.187 11.084  1.00 46.36 ? 922  PRO   A CD  1 
ATOM   1648 N N   . ALA   A 1 230 ? -10.871 -22.227 8.610   1.00 47.24 ? 923  ALA   A N   1 
ATOM   1649 C CA  . ALA   A 1 230 ? -12.032 -23.114 8.633   1.00 47.50 ? 923  ALA   A CA  1 
ATOM   1650 C C   . ALA   A 1 230 ? -11.608 -24.566 8.811   1.00 47.66 ? 923  ALA   A C   1 
ATOM   1651 O O   . ALA   A 1 230 ? -12.251 -25.303 9.551   1.00 47.91 ? 923  ALA   A O   1 
ATOM   1652 C CB  . ALA   A 1 230 ? -12.835 -22.961 7.356   1.00 47.67 ? 923  ALA   A CB  1 
ATOM   1653 N N   . SER   A 1 231 ? -10.503 -24.966 8.169   1.00 47.44 ? 924  SER   A N   1 
ATOM   1654 C CA  . SER   A 1 231 ? -9.965  -26.328 8.267   1.00 47.60 ? 924  SER   A CA  1 
ATOM   1655 C C   . SER   A 1 231 ? -9.662  -26.721 9.716   1.00 47.02 ? 924  SER   A C   1 
ATOM   1656 O O   . SER   A 1 231 ? -9.870  -27.873 10.110  1.00 47.26 ? 924  SER   A O   1 
ATOM   1657 C CB  . SER   A 1 231 ? -8.692  -26.450 7.433   1.00 49.36 ? 924  SER   A CB  1 
ATOM   1658 O OG  . SER   A 1 231 ? -7.776  -25.406 7.732   1.00 52.10 ? 924  SER   A OG  1 
ATOM   1659 N N   . GLU   A 1 232 ? -9.181  -25.752 10.502  1.00 46.05 ? 925  GLU   A N   1 
ATOM   1660 C CA  . GLU   A 1 232 ? -8.818  -25.947 11.894  1.00 45.77 ? 925  GLU   A CA  1 
ATOM   1661 C C   . GLU   A 1 232 ? -10.004 -26.197 12.830  1.00 44.70 ? 925  GLU   A C   1 
ATOM   1662 O O   . GLU   A 1 232 ? -9.936  -27.134 13.618  1.00 44.91 ? 925  GLU   A O   1 
ATOM   1663 C CB  . GLU   A 1 232 ? -7.974  -24.766 12.389  1.00 48.43 ? 925  GLU   A CB  1 
ATOM   1664 C CG  . GLU   A 1 232 ? -6.626  -25.172 12.954  1.00 53.65 ? 925  GLU   A CG  1 
ATOM   1665 C CD  . GLU   A 1 232 ? -5.641  -24.024 13.054  1.00 60.22 ? 925  GLU   A CD  1 
ATOM   1666 O OE1 . GLU   A 1 232 ? -5.789  -23.190 13.976  1.00 61.28 ? 925  GLU   A OE1 1 
ATOM   1667 O OE2 . GLU   A 1 232 ? -4.720  -23.957 12.207  1.00 62.48 ? 925  GLU   A OE2 1 
ATOM   1668 N N   . ILE   A 1 233 ? -11.073 -25.372 12.744  1.00 43.35 ? 926  ILE   A N   1 
ATOM   1669 C CA  . ILE   A 1 233 ? -12.288 -25.408 13.582  1.00 42.49 ? 926  ILE   A CA  1 
ATOM   1670 C C   . ILE   A 1 233 ? -12.675 -26.788 14.138  1.00 41.66 ? 926  ILE   A C   1 
ATOM   1671 O O   . ILE   A 1 233 ? -12.884 -26.910 15.344  1.00 41.83 ? 926  ILE   A O   1 
ATOM   1672 C CB  . ILE   A 1 233 ? -13.486 -24.781 12.844  1.00 42.75 ? 926  ILE   A CB  1 
ATOM   1673 C CG1 . ILE   A 1 233 ? -13.166 -23.353 12.366  1.00 43.52 ? 926  ILE   A CG1 1 
ATOM   1674 C CG2 . ILE   A 1 233 ? -14.770 -24.835 13.683  1.00 43.06 ? 926  ILE   A CG2 1 
ATOM   1675 C CD1 . ILE   A 1 233 ? -12.857 -22.410 13.420  1.00 44.39 ? 926  ILE   A CD1 1 
ATOM   1676 N N   . SER   A 1 234 ? -12.744 -27.821 13.285  1.00 40.62 ? 927  SER   A N   1 
ATOM   1677 C CA  . SER   A 1 234 ? -13.096 -29.187 13.683  1.00 40.06 ? 927  SER   A CA  1 
ATOM   1678 C C   . SER   A 1 234 ? -12.280 -29.684 14.874  1.00 39.33 ? 927  SER   A C   1 
ATOM   1679 O O   . SER   A 1 234 ? -12.855 -30.147 15.852  1.00 39.46 ? 927  SER   A O   1 
ATOM   1680 C CB  . SER   A 1 234 ? -12.925 -30.137 12.504  1.00 41.50 ? 927  SER   A CB  1 
ATOM   1681 O OG  . SER   A 1 234 ? -11.617 -30.020 11.966  1.00 43.93 ? 927  SER   A OG  1 
ATOM   1682 N N   . SER   A 1 235 ? -10.952 -29.544 14.817  1.00 38.61 ? 928  SER   A N   1 
ATOM   1683 C CA  . SER   A 1 235 ? -10.091 -29.966 15.911  1.00 38.56 ? 928  SER   A CA  1 
ATOM   1684 C C   . SER   A 1 235 ? -10.227 -29.044 17.119  1.00 38.28 ? 928  SER   A C   1 
ATOM   1685 O O   . SER   A 1 235 ? -10.164 -29.523 18.248  1.00 38.94 ? 928  SER   A O   1 
ATOM   1686 C CB  . SER   A 1 235 ? -8.636  -30.066 15.460  1.00 40.01 ? 928  SER   A CB  1 
ATOM   1687 O OG  . SER   A 1 235 ? -8.110  -28.821 15.033  1.00 42.63 ? 928  SER   A OG  1 
ATOM   1688 N N   . ILE   A 1 236 ? -10.477 -27.748 16.896  1.00 37.30 ? 929  ILE   A N   1 
ATOM   1689 C CA  . ILE   A 1 236 ? -10.655 -26.760 17.964  1.00 37.09 ? 929  ILE   A CA  1 
ATOM   1690 C C   . ILE   A 1 236 ? -11.881 -27.098 18.820  1.00 36.41 ? 929  ILE   A C   1 
ATOM   1691 O O   . ILE   A 1 236 ? -11.808 -27.051 20.040  1.00 36.58 ? 929  ILE   A O   1 
ATOM   1692 C CB  . ILE   A 1 236 ? -10.666 -25.313 17.381  1.00 37.71 ? 929  ILE   A CB  1 
ATOM   1693 C CG1 . ILE   A 1 236 ? -9.229  -24.797 17.173  1.00 38.81 ? 929  ILE   A CG1 1 
ATOM   1694 C CG2 . ILE   A 1 236 ? -11.450 -24.318 18.254  1.00 38.01 ? 929  ILE   A CG2 1 
ATOM   1695 C CD1 . ILE   A 1 236 ? -8.328  -25.612 16.252  1.00 39.86 ? 929  ILE   A CD1 1 
ATOM   1696 N N   . LEU   A 1 237 ? -12.982 -27.493 18.182  1.00 35.74 ? 930  LEU   A N   1 
ATOM   1697 C CA  . LEU   A 1 237 ? -14.198 -27.885 18.888  1.00 35.53 ? 930  LEU   A CA  1 
ATOM   1698 C C   . LEU   A 1 237 ? -14.027 -29.213 19.624  1.00 35.53 ? 930  LEU   A C   1 
ATOM   1699 O O   . LEU   A 1 237 ? -14.682 -29.420 20.641  1.00 35.97 ? 930  LEU   A O   1 
ATOM   1700 C CB  . LEU   A 1 237 ? -15.388 -27.962 17.927  1.00 35.65 ? 930  LEU   A CB  1 
ATOM   1701 C CG  . LEU   A 1 237 ? -15.781 -26.653 17.263  1.00 36.75 ? 930  LEU   A CG  1 
ATOM   1702 C CD1 . LEU   A 1 237 ? -16.854 -26.874 16.209  1.00 37.17 ? 930  LEU   A CD1 1 
ATOM   1703 C CD2 . LEU   A 1 237 ? -16.213 -25.629 18.291  1.00 37.11 ? 930  LEU   A CD2 1 
ATOM   1704 N N   . GLU   A 1 238 ? -13.146 -30.103 19.130  1.00 35.10 ? 931  GLU   A N   1 
ATOM   1705 C CA  . GLU   A 1 238 ? -12.836 -31.382 19.773  1.00 35.23 ? 931  GLU   A CA  1 
ATOM   1706 C C   . GLU   A 1 238 ? -11.976 -31.169 21.045  1.00 35.25 ? 931  GLU   A C   1 
ATOM   1707 O O   . GLU   A 1 238 ? -12.171 -31.844 22.069  1.00 35.04 ? 931  GLU   A O   1 
ATOM   1708 C CB  . GLU   A 1 238 ? -12.186 -32.347 18.779  1.00 36.92 ? 931  GLU   A CB  1 
ATOM   1709 C CG  . GLU   A 1 238 ? -13.228 -32.933 17.853  1.00 41.60 ? 931  GLU   A CG  1 
ATOM   1710 C CD  . GLU   A 1 238 ? -12.706 -33.828 16.750  1.00 47.81 ? 931  GLU   A CD  1 
ATOM   1711 O OE1 . GLU   A 1 238 ? -11.858 -33.361 15.956  1.00 48.36 ? 931  GLU   A OE1 1 
ATOM   1712 O OE2 . GLU   A 1 238 ? -13.157 -34.995 16.672  1.00 50.05 ? 931  GLU   A OE2 1 
ATOM   1713 N N   . LYS   A 1 239 ? -11.068 -30.177 20.996  1.00 34.88 ? 932  LYS   A N   1 
ATOM   1714 C CA  . LYS   A 1 239 ? -10.281 -29.806 22.172  1.00 34.67 ? 932  LYS   A CA  1 
ATOM   1715 C C   . LYS   A 1 239 ? -11.125 -29.062 23.242  1.00 33.84 ? 932  LYS   A C   1 
ATOM   1716 O O   . LYS   A 1 239 ? -10.575 -28.618 24.249  1.00 33.90 ? 932  LYS   A O   1 
ATOM   1717 C CB  . LYS   A 1 239 ? -9.067  -28.960 21.766  1.00 37.08 ? 932  LYS   A CB  1 
ATOM   1718 C CG  . LYS   A 1 239 ? -8.049  -29.714 20.923  1.00 42.17 ? 932  LYS   A CG  1 
ATOM   1719 C CD  . LYS   A 1 239 ? -6.938  -28.794 20.431  1.00 47.95 ? 932  LYS   A CD  1 
ATOM   1720 C CE  . LYS   A 1 239 ? -7.203  -28.272 19.036  1.00 53.00 ? 932  LYS   A CE  1 
ATOM   1721 N NZ  . LYS   A 1 239 ? -6.177  -27.289 18.588  1.00 55.91 ? 932  LYS   A NZ  1 
ATOM   1722 N N   . GLY   A 1 240 ? -12.434 -28.944 23.020  1.00 33.00 ? 933  GLY   A N   1 
ATOM   1723 C CA  . GLY   A 1 240 ? -13.358 -28.318 23.947  1.00 32.95 ? 933  GLY   A CA  1 
ATOM   1724 C C   . GLY   A 1 240 ? -13.219 -26.819 24.048  1.00 32.73 ? 933  GLY   A C   1 
ATOM   1725 O O   . GLY   A 1 240 ? -13.590 -26.239 25.074  1.00 33.09 ? 933  GLY   A O   1 
ATOM   1726 N N   . GLU   A 1 241 ? -12.686 -26.175 22.996  1.00 31.75 ? 934  GLU   A N   1 
ATOM   1727 C CA  . GLU   A 1 241 ? -12.548 -24.723 23.006  1.00 31.26 ? 934  GLU   A CA  1 
ATOM   1728 C C   . GLU   A 1 241 ? -13.784 -24.151 22.340  1.00 30.57 ? 934  GLU   A C   1 
ATOM   1729 O O   . GLU   A 1 241 ? -14.208 -24.655 21.304  1.00 30.51 ? 934  GLU   A O   1 
ATOM   1730 C CB  . GLU   A 1 241 ? -11.291 -24.271 22.246  1.00 33.63 ? 934  GLU   A CB  1 
ATOM   1731 C CG  . GLU   A 1 241 ? -10.040 -25.102 22.495  1.00 38.70 ? 934  GLU   A CG  1 
ATOM   1732 C CD  . GLU   A 1 241 ? -8.919  -24.864 21.494  1.00 44.69 ? 934  GLU   A CD  1 
ATOM   1733 O OE1 . GLU   A 1 241 ? -8.409  -23.721 21.436  1.00 46.63 ? 934  GLU   A OE1 1 
ATOM   1734 O OE2 . GLU   A 1 241 ? -8.546  -25.815 20.770  1.00 45.21 ? 934  GLU   A OE2 1 
ATOM   1735 N N   . ARG   A 1 242 ? -14.381 -23.121 22.932  1.00 30.14 ? 935  ARG   A N   1 
ATOM   1736 C CA  . ARG   A 1 242 ? -15.570 -22.490 22.349  1.00 30.35 ? 935  ARG   A CA  1 
ATOM   1737 C C   . ARG   A 1 242 ? -15.391 -20.967 22.117  1.00 30.63 ? 935  ARG   A C   1 
ATOM   1738 O O   . ARG   A 1 242 ? -14.362 -20.391 22.483  1.00 30.87 ? 935  ARG   A O   1 
ATOM   1739 C CB  . ARG   A 1 242 ? -16.809 -22.757 23.226  1.00 30.76 ? 935  ARG   A CB  1 
ATOM   1740 C CG  . ARG   A 1 242 ? -17.240 -24.201 23.271  1.00 32.26 ? 935  ARG   A CG  1 
ATOM   1741 C CD  . ARG   A 1 242 ? -17.616 -24.776 21.923  1.00 33.95 ? 935  ARG   A CD  1 
ATOM   1742 N NE  . ARG   A 1 242 ? -18.061 -26.163 22.065  1.00 36.20 ? 935  ARG   A NE  1 
ATOM   1743 C CZ  . ARG   A 1 242 ? -17.247 -27.216 22.076  1.00 38.60 ? 935  ARG   A CZ  1 
ATOM   1744 N NH1 . ARG   A 1 242 ? -17.736 -28.438 22.228  1.00 38.48 ? 935  ARG   A NH1 1 
ATOM   1745 N NH2 . ARG   A 1 242 ? -15.937 -27.054 21.937  1.00 38.66 ? 935  ARG   A NH2 1 
ATOM   1746 N N   . LEU   A 1 243 ? -16.409 -20.301 21.530  1.00 30.19 ? 936  LEU   A N   1 
ATOM   1747 C CA  . LEU   A 1 243 ? -16.400 -18.855 21.364  1.00 30.29 ? 936  LEU   A CA  1 
ATOM   1748 C C   . LEU   A 1 243 ? -16.381 -18.228 22.762  1.00 30.33 ? 936  LEU   A C   1 
ATOM   1749 O O   . LEU   A 1 243 ? -16.996 -18.771 23.682  1.00 30.32 ? 936  LEU   A O   1 
ATOM   1750 C CB  . LEU   A 1 243 ? -17.659 -18.404 20.614  1.00 30.50 ? 936  LEU   A CB  1 
ATOM   1751 C CG  . LEU   A 1 243 ? -17.775 -18.824 19.175  1.00 32.12 ? 936  LEU   A CG  1 
ATOM   1752 C CD1 . LEU   A 1 243 ? -19.095 -18.383 18.594  1.00 32.73 ? 936  LEU   A CD1 1 
ATOM   1753 C CD2 . LEU   A 1 243 ? -16.659 -18.251 18.366  1.00 32.92 ? 936  LEU   A CD2 1 
ATOM   1754 N N   . PRO   A 1 244 ? -15.600 -17.158 22.969  1.00 30.30 ? 937  PRO   A N   1 
ATOM   1755 C CA  . PRO   A 1 244 ? -15.483 -16.591 24.322  1.00 30.56 ? 937  PRO   A CA  1 
ATOM   1756 C C   . PRO   A 1 244 ? -16.765 -15.978 24.880  1.00 31.13 ? 937  PRO   A C   1 
ATOM   1757 O O   . PRO   A 1 244 ? -17.756 -15.853 24.169  1.00 31.24 ? 937  PRO   A O   1 
ATOM   1758 C CB  . PRO   A 1 244 ? -14.366 -15.552 24.167  1.00 31.13 ? 937  PRO   A CB  1 
ATOM   1759 C CG  . PRO   A 1 244 ? -14.394 -15.178 22.721  1.00 31.15 ? 937  PRO   A CG  1 
ATOM   1760 C CD  . PRO   A 1 244 ? -14.759 -16.432 21.999  1.00 29.60 ? 937  PRO   A CD  1 
ATOM   1761 N N   . GLN   A 1 245 ? -16.753 -15.624 26.164  1.00 31.61 ? 938  GLN   A N   1 
ATOM   1762 C CA  . GLN   A 1 245 ? -17.907 -14.986 26.781  1.00 32.64 ? 938  GLN   A CA  1 
ATOM   1763 C C   . GLN   A 1 245 ? -17.898 -13.508 26.403  1.00 33.18 ? 938  GLN   A C   1 
ATOM   1764 O O   . GLN   A 1 245 ? -16.925 -12.802 26.665  1.00 33.73 ? 938  GLN   A O   1 
ATOM   1765 C CB  . GLN   A 1 245 ? -17.903 -15.164 28.305  1.00 34.34 ? 938  GLN   A CB  1 
ATOM   1766 C CG  . GLN   A 1 245 ? -19.059 -14.442 28.994  1.00 37.53 ? 938  GLN   A CG  1 
ATOM   1767 C CD  . GLN   A 1 245 ? -19.103 -14.665 30.488  1.00 40.91 ? 938  GLN   A CD  1 
ATOM   1768 O OE1 . GLN   A 1 245 ? -19.389 -13.749 31.261  1.00 42.02 ? 938  GLN   A OE1 1 
ATOM   1769 N NE2 . GLN   A 1 245 ? -18.830 -15.881 30.928  1.00 41.41 ? 938  GLN   A NE2 1 
ATOM   1770 N N   . PRO   A 1 246 ? -18.969 -13.032 25.764  1.00 32.72 ? 939  PRO   A N   1 
ATOM   1771 C CA  . PRO   A 1 246 ? -19.015 -11.630 25.350  1.00 32.47 ? 939  PRO   A CA  1 
ATOM   1772 C C   . PRO   A 1 246 ? -18.948 -10.660 26.529  1.00 32.19 ? 939  PRO   A C   1 
ATOM   1773 O O   . PRO   A 1 246 ? -19.440 -10.973 27.611  1.00 32.42 ? 939  PRO   A O   1 
ATOM   1774 C CB  . PRO   A 1 246 ? -20.345 -11.545 24.597  1.00 33.19 ? 939  PRO   A CB  1 
ATOM   1775 C CG  . PRO   A 1 246 ? -20.633 -12.949 24.176  1.00 33.57 ? 939  PRO   A CG  1 
ATOM   1776 C CD  . PRO   A 1 246 ? -20.181 -13.750 25.344  1.00 32.20 ? 939  PRO   A CD  1 
ATOM   1777 N N   . PRO   A 1 247 ? -18.330 -9.477  26.335  1.00 31.67 ? 940  PRO   A N   1 
ATOM   1778 C CA  . PRO   A 1 247 ? -18.169 -8.526  27.442  1.00 31.82 ? 940  PRO   A CA  1 
ATOM   1779 C C   . PRO   A 1 247 ? -19.448 -7.912  28.007  1.00 32.22 ? 940  PRO   A C   1 
ATOM   1780 O O   . PRO   A 1 247 ? -19.384 -7.081  28.910  1.00 32.61 ? 940  PRO   A O   1 
ATOM   1781 C CB  . PRO   A 1 247 ? -17.247 -7.454  26.850  1.00 32.36 ? 940  PRO   A CB  1 
ATOM   1782 C CG  . PRO   A 1 247 ? -16.587 -8.110  25.699  1.00 32.60 ? 940  PRO   A CG  1 
ATOM   1783 C CD  . PRO   A 1 247 ? -17.655 -8.980  25.129  1.00 31.12 ? 940  PRO   A CD  1 
ATOM   1784 N N   . ILE   A 1 248 ? -20.597 -8.302  27.483  1.00 31.99 ? 941  ILE   A N   1 
ATOM   1785 C CA  . ILE   A 1 248 ? -21.879 -7.857  28.009  1.00 32.30 ? 941  ILE   A CA  1 
ATOM   1786 C C   . ILE   A 1 248 ? -22.641 -9.019  28.671  1.00 32.44 ? 941  ILE   A C   1 
ATOM   1787 O O   . ILE   A 1 248 ? -23.471 -8.790  29.537  1.00 32.34 ? 941  ILE   A O   1 
ATOM   1788 C CB  . ILE   A 1 248 ? -22.699 -7.155  26.910  1.00 32.87 ? 941  ILE   A CB  1 
ATOM   1789 C CG1 . ILE   A 1 248 ? -22.919 -8.091  25.705  1.00 34.03 ? 941  ILE   A CG1 1 
ATOM   1790 C CG2 . ILE   A 1 248 ? -22.008 -5.852  26.490  1.00 33.29 ? 941  ILE   A CG2 1 
ATOM   1791 C CD1 . ILE   A 1 248 ? -23.794 -7.507  24.590  1.00 35.29 ? 941  ILE   A CD1 1 
ATOM   1792 N N   . CYS   A 1 249 ? -22.316 -10.265 28.296  1.00 32.65 ? 942  CYS   A N   1 
ATOM   1793 C CA  . CYS   A 1 249 ? -22.943 -11.490 28.759  1.00 33.29 ? 942  CYS   A CA  1 
ATOM   1794 C C   . CYS   A 1 249 ? -22.614 -11.896 30.178  1.00 33.46 ? 942  CYS   A C   1 
ATOM   1795 O O   . CYS   A 1 249 ? -21.459 -12.194 30.482  1.00 33.70 ? 942  CYS   A O   1 
ATOM   1796 C CB  . CYS   A 1 249 ? -22.628 -12.628 27.798  1.00 34.07 ? 942  CYS   A CB  1 
ATOM   1797 S SG  . CYS   A 1 249 ? -23.529 -12.537 26.240  1.00 37.46 ? 942  CYS   A SG  1 
ATOM   1798 N N   . THR   A 1 250 ? -23.648 -12.012 31.021  1.00 33.04 ? 943  THR   A N   1 
ATOM   1799 C CA  . THR   A 1 250 ? -23.460 -12.553 32.358  1.00 33.18 ? 943  THR   A CA  1 
ATOM   1800 C C   . THR   A 1 250 ? -23.293 -14.073 32.186  1.00 33.18 ? 943  THR   A C   1 
ATOM   1801 O O   . THR   A 1 250 ? -23.776 -14.638 31.192  1.00 33.53 ? 943  THR   A O   1 
ATOM   1802 C CB  . THR   A 1 250 ? -24.640 -12.194 33.246  1.00 34.00 ? 943  THR   A CB  1 
ATOM   1803 O OG1 . THR   A 1 250 ? -25.825 -12.792 32.711  1.00 34.80 ? 943  THR   A OG1 1 
ATOM   1804 C CG2 . THR   A 1 250 ? -24.798 -10.684 33.398  1.00 34.16 ? 943  THR   A CG2 1 
ATOM   1805 N N   . ILE   A 1 251 ? -22.603 -14.747 33.131  1.00 32.42 ? 944  ILE   A N   1 
ATOM   1806 C CA  . ILE   A 1 251 ? -22.366 -16.203 33.075  1.00 32.16 ? 944  ILE   A CA  1 
ATOM   1807 C C   . ILE   A 1 251 ? -23.677 -16.986 32.778  1.00 31.56 ? 944  ILE   A C   1 
ATOM   1808 O O   . ILE   A 1 251 ? -23.646 -18.013 32.110  1.00 31.06 ? 944  ILE   A O   1 
ATOM   1809 C CB  . ILE   A 1 251 ? -21.614 -16.682 34.373  1.00 32.79 ? 944  ILE   A CB  1 
ATOM   1810 C CG1 . ILE   A 1 251 ? -20.130 -17.018 34.083  1.00 34.02 ? 944  ILE   A CG1 1 
ATOM   1811 C CG2 . ILE   A 1 251 ? -22.312 -17.824 35.132  1.00 32.90 ? 944  ILE   A CG2 1 
ATOM   1812 C CD1 . ILE   A 1 251 ? -19.144 -15.858 34.350  1.00 35.41 ? 944  ILE   A CD1 1 
ATOM   1813 N N   . ASP   A 1 252 ? -24.819 -16.423 33.218  1.00 31.48 ? 945  ASP   A N   1 
ATOM   1814 C CA  . ASP   A 1 252 ? -26.160 -16.962 33.045  1.00 31.76 ? 945  ASP   A CA  1 
ATOM   1815 C C   . ASP   A 1 252 ? -26.489 -17.130 31.594  1.00 30.93 ? 945  ASP   A C   1 
ATOM   1816 O O   . ASP   A 1 252 ? -26.925 -18.205 31.188  1.00 31.04 ? 945  ASP   A O   1 
ATOM   1817 C CB  . ASP   A 1 252 ? -27.201 -16.026 33.696  1.00 34.23 ? 945  ASP   A CB  1 
ATOM   1818 C CG  . ASP   A 1 252 ? -27.202 -16.072 35.202  1.00 39.10 ? 945  ASP   A CG  1 
ATOM   1819 O OD1 . ASP   A 1 252 ? -26.780 -17.111 35.761  1.00 39.93 ? 945  ASP   A OD1 1 
ATOM   1820 O OD2 . ASP   A 1 252 ? -27.631 -15.068 35.827  1.00 41.29 ? 945  ASP   A OD2 1 
ATOM   1821 N N   . VAL   A 1 253 ? -26.261 -16.066 30.814  1.00 30.04 ? 946  VAL   A N   1 
ATOM   1822 C CA  . VAL   A 1 253 ? -26.542 -15.992 29.391  1.00 29.64 ? 946  VAL   A CA  1 
ATOM   1823 C C   . VAL   A 1 253 ? -25.526 -16.796 28.611  1.00 28.94 ? 946  VAL   A C   1 
ATOM   1824 O O   . VAL   A 1 253 ? -25.915 -17.633 27.798  1.00 29.22 ? 946  VAL   A O   1 
ATOM   1825 C CB  . VAL   A 1 253 ? -26.594 -14.520 28.931  1.00 30.46 ? 946  VAL   A CB  1 
ATOM   1826 C CG1 . VAL   A 1 253 ? -26.972 -14.411 27.455  1.00 30.82 ? 946  VAL   A CG1 1 
ATOM   1827 C CG2 . VAL   A 1 253 ? -27.562 -13.729 29.795  1.00 31.01 ? 946  VAL   A CG2 1 
ATOM   1828 N N   . TYR   A 1 254 ? -24.229 -16.597 28.896  1.00 27.92 ? 947  TYR   A N   1 
ATOM   1829 C CA  . TYR   A 1 254 ? -23.170 -17.336 28.219  1.00 27.47 ? 947  TYR   A CA  1 
ATOM   1830 C C   . TYR   A 1 254 ? -23.298 -18.855 28.430  1.00 26.76 ? 947  TYR   A C   1 
ATOM   1831 O O   . TYR   A 1 254 ? -22.863 -19.620 27.574  1.00 26.80 ? 947  TYR   A O   1 
ATOM   1832 C CB  . TYR   A 1 254 ? -21.781 -16.787 28.592  1.00 27.69 ? 947  TYR   A CB  1 
ATOM   1833 C CG  . TYR   A 1 254 ? -20.627 -17.610 28.067  1.00 28.83 ? 947  TYR   A CG  1 
ATOM   1834 C CD1 . TYR   A 1 254 ? -20.320 -17.632 26.714  1.00 29.85 ? 947  TYR   A CD1 1 
ATOM   1835 C CD2 . TYR   A 1 254 ? -19.867 -18.396 28.917  1.00 30.19 ? 947  TYR   A CD2 1 
ATOM   1836 C CE1 . TYR   A 1 254 ? -19.281 -18.417 26.223  1.00 30.88 ? 947  TYR   A CE1 1 
ATOM   1837 C CE2 . TYR   A 1 254 ? -18.833 -19.190 28.438  1.00 31.19 ? 947  TYR   A CE2 1 
ATOM   1838 C CZ  . TYR   A 1 254 ? -18.541 -19.201 27.090  1.00 31.70 ? 947  TYR   A CZ  1 
ATOM   1839 O OH  . TYR   A 1 254 ? -17.516 -20.003 26.642  1.00 32.69 ? 947  TYR   A OH  1 
ATOM   1840 N N   . MET   A 1 255 ? -23.957 -19.294 29.514  1.00 26.19 ? 948  MET   A N   1 
ATOM   1841 C CA  . MET   A 1 255 ? -24.175 -20.720 29.740  1.00 26.27 ? 948  MET   A CA  1 
ATOM   1842 C C   . MET   A 1 255 ? -25.201 -21.291 28.774  1.00 25.58 ? 948  MET   A C   1 
ATOM   1843 O O   . MET   A 1 255 ? -25.054 -22.437 28.346  1.00 25.80 ? 948  MET   A O   1 
ATOM   1844 C CB  . MET   A 1 255 ? -24.498 -21.046 31.208  1.00 27.46 ? 948  MET   A CB  1 
ATOM   1845 C CG  . MET   A 1 255 ? -23.251 -21.158 32.080  1.00 30.51 ? 948  MET   A CG  1 
ATOM   1846 S SD  . MET   A 1 255 ? -22.034 -22.375 31.493  1.00 37.52 ? 948  MET   A SD  1 
ATOM   1847 C CE  . MET   A 1 255 ? -20.706 -21.284 30.927  1.00 34.40 ? 948  MET   A CE  1 
ATOM   1848 N N   . ILE   A 1 256 ? -26.202 -20.479 28.368  1.00 24.51 ? 949  ILE   A N   1 
ATOM   1849 C CA  . ILE   A 1 256 ? -27.188 -20.890 27.363  1.00 23.74 ? 949  ILE   A CA  1 
ATOM   1850 C C   . ILE   A 1 256 ? -26.463 -21.131 26.040  1.00 23.67 ? 949  ILE   A C   1 
ATOM   1851 O O   . ILE   A 1 256 ? -26.680 -22.147 25.379  1.00 23.92 ? 949  ILE   A O   1 
ATOM   1852 C CB  . ILE   A 1 256 ? -28.306 -19.833 27.191  1.00 23.39 ? 949  ILE   A CB  1 
ATOM   1853 C CG1 . ILE   A 1 256 ? -29.088 -19.618 28.497  1.00 23.50 ? 949  ILE   A CG1 1 
ATOM   1854 C CG2 . ILE   A 1 256 ? -29.225 -20.248 26.056  1.00 23.96 ? 949  ILE   A CG2 1 
ATOM   1855 C CD1 . ILE   A 1 256 ? -30.197 -18.615 28.419  1.00 24.03 ? 949  ILE   A CD1 1 
ATOM   1856 N N   . MET   A 1 257 ? -25.571 -20.199 25.691  1.00 23.37 ? 950  MET   A N   1 
ATOM   1857 C CA  . MET   A 1 257 ? -24.758 -20.217 24.496  1.00 23.55 ? 950  MET   A CA  1 
ATOM   1858 C C   . MET   A 1 257 ? -23.835 -21.425 24.482  1.00 23.29 ? 950  MET   A C   1 
ATOM   1859 O O   . MET   A 1 257 ? -23.762 -22.127 23.479  1.00 23.46 ? 950  MET   A O   1 
ATOM   1860 C CB  . MET   A 1 257 ? -23.943 -18.923 24.439  1.00 24.39 ? 950  MET   A CB  1 
ATOM   1861 C CG  . MET   A 1 257 ? -24.559 -17.886 23.575  1.00 27.40 ? 950  MET   A CG  1 
ATOM   1862 S SD  . MET   A 1 257 ? -23.719 -16.319 23.796  1.00 33.46 ? 950  MET   A SD  1 
ATOM   1863 C CE  . MET   A 1 257 ? -24.540 -15.784 25.195  1.00 31.68 ? 950  MET   A CE  1 
ATOM   1864 N N   . ARG   A 1 258 ? -23.148 -21.678 25.601  1.00 22.70 ? 951  ARG   A N   1 
ATOM   1865 C CA  . ARG   A 1 258 ? -22.209 -22.780 25.756  1.00 22.76 ? 951  ARG   A CA  1 
ATOM   1866 C C   . ARG   A 1 258 ? -22.942 -24.149 25.659  1.00 23.13 ? 951  ARG   A C   1 
ATOM   1867 O O   . ARG   A 1 258 ? -22.429 -25.091 25.042  1.00 23.15 ? 951  ARG   A O   1 
ATOM   1868 C CB  . ARG   A 1 258 ? -21.437 -22.576 27.076  1.00 23.39 ? 951  ARG   A CB  1 
ATOM   1869 C CG  . ARG   A 1 258 ? -20.456 -23.663 27.481  1.00 24.84 ? 951  ARG   A CG  1 
ATOM   1870 C CD  . ARG   A 1 258 ? -19.388 -23.918 26.449  1.00 25.87 ? 951  ARG   A CD  1 
ATOM   1871 N NE  . ARG   A 1 258 ? -19.563 -25.244 25.860  1.00 26.38 ? 951  ARG   A NE  1 
ATOM   1872 C CZ  . ARG   A 1 258 ? -18.683 -26.234 25.954  1.00 26.94 ? 951  ARG   A CZ  1 
ATOM   1873 N NH1 . ARG   A 1 258 ? -17.538 -26.054 26.601  1.00 25.87 ? 951  ARG   A NH1 1 
ATOM   1874 N NH2 . ARG   A 1 258 ? -18.928 -27.403 25.381  1.00 26.72 ? 951  ARG   A NH2 1 
ATOM   1875 N N   . LYS   A 1 259 ? -24.181 -24.217 26.189  1.00 23.06 ? 952  LYS   A N   1 
ATOM   1876 C CA  . LYS   A 1 259 ? -25.016 -25.416 26.137  1.00 23.25 ? 952  LYS   A CA  1 
ATOM   1877 C C   . LYS   A 1 259 ? -25.383 -25.775 24.709  1.00 23.99 ? 952  LYS   A C   1 
ATOM   1878 O O   . LYS   A 1 259 ? -25.505 -26.954 24.408  1.00 24.12 ? 952  LYS   A O   1 
ATOM   1879 C CB  . LYS   A 1 259 ? -26.289 -25.241 26.978  1.00 24.41 ? 952  LYS   A CB  1 
ATOM   1880 C CG  . LYS   A 1 259 ? -26.132 -25.627 28.453  1.00 26.76 ? 952  LYS   A CG  1 
ATOM   1881 C CD  . LYS   A 1 259 ? -27.242 -26.575 28.946  1.00 30.06 ? 952  LYS   A CD  1 
ATOM   1882 C CE  . LYS   A 1 259 ? -27.278 -26.720 30.467  1.00 34.08 ? 952  LYS   A CE  1 
ATOM   1883 N NZ  . LYS   A 1 259 ? -26.171 -27.558 31.011  1.00 35.41 ? 952  LYS   A NZ  1 
ATOM   1884 N N   . CYS   A 1 260 ? -25.581 -24.770 23.831  1.00 24.48 ? 953  CYS   A N   1 
ATOM   1885 C CA  . CYS   A 1 260 ? -25.902 -24.991 22.404  1.00 25.65 ? 953  CYS   A CA  1 
ATOM   1886 C C   . CYS   A 1 260 ? -24.743 -25.673 21.674  1.00 26.11 ? 953  CYS   A C   1 
ATOM   1887 O O   . CYS   A 1 260 ? -24.958 -26.428 20.735  1.00 25.79 ? 953  CYS   A O   1 
ATOM   1888 C CB  . CYS   A 1 260 ? -26.260 -23.679 21.711  1.00 26.82 ? 953  CYS   A CB  1 
ATOM   1889 S SG  . CYS   A 1 260 ? -27.772 -22.889 22.313  1.00 31.81 ? 953  CYS   A SG  1 
ATOM   1890 N N   . TRP   A 1 261 ? -23.512 -25.386 22.104  1.00 26.78 ? 954  TRP   A N   1 
ATOM   1891 C CA  . TRP   A 1 261 ? -22.297 -25.895 21.497  1.00 27.73 ? 954  TRP   A CA  1 
ATOM   1892 C C   . TRP   A 1 261 ? -21.803 -27.209 22.097  1.00 28.83 ? 954  TRP   A C   1 
ATOM   1893 O O   . TRP   A 1 261 ? -20.616 -27.509 21.992  1.00 29.08 ? 954  TRP   A O   1 
ATOM   1894 C CB  . TRP   A 1 261 ? -21.207 -24.816 21.540  1.00 27.51 ? 954  TRP   A CB  1 
ATOM   1895 C CG  . TRP   A 1 261 ? -21.664 -23.479 21.030  1.00 27.82 ? 954  TRP   A CG  1 
ATOM   1896 C CD1 . TRP   A 1 261 ? -22.549 -23.239 20.018  1.00 28.75 ? 954  TRP   A CD1 1 
ATOM   1897 C CD2 . TRP   A 1 261 ? -21.233 -22.202 21.496  1.00 27.83 ? 954  TRP   A CD2 1 
ATOM   1898 N NE1 . TRP   A 1 261 ? -22.718 -21.889 19.850  1.00 28.97 ? 954  TRP   A NE1 1 
ATOM   1899 C CE2 . TRP   A 1 261 ? -21.918 -21.227 20.744  1.00 28.59 ? 954  TRP   A CE2 1 
ATOM   1900 C CE3 . TRP   A 1 261 ? -20.339 -21.784 22.485  1.00 28.51 ? 954  TRP   A CE3 1 
ATOM   1901 C CZ2 . TRP   A 1 261 ? -21.719 -19.866 20.935  1.00 29.20 ? 954  TRP   A CZ2 1 
ATOM   1902 C CZ3 . TRP   A 1 261 ? -20.157 -20.433 22.684  1.00 29.40 ? 954  TRP   A CZ3 1 
ATOM   1903 C CH2 . TRP   A 1 261 ? -20.841 -19.491 21.910  1.00 29.49 ? 954  TRP   A CH2 1 
ATOM   1904 N N   . MET   A 1 262 ? -22.713 -28.000 22.706  1.00 29.15 ? 955  MET   A N   1 
ATOM   1905 C CA  . MET   A 1 262 ? -22.393 -29.318 23.275  1.00 29.51 ? 955  MET   A CA  1 
ATOM   1906 C C   . MET   A 1 262 ? -22.110 -30.311 22.155  1.00 29.77 ? 955  MET   A C   1 
ATOM   1907 O O   . MET   A 1 262 ? -22.540 -30.089 21.030  1.00 29.89 ? 955  MET   A O   1 
ATOM   1908 C CB  . MET   A 1 262 ? -23.544 -29.833 24.148  1.00 29.85 ? 955  MET   A CB  1 
ATOM   1909 C CG  . MET   A 1 262 ? -23.499 -29.315 25.555  1.00 31.43 ? 955  MET   A CG  1 
ATOM   1910 S SD  . MET   A 1 262 ? -24.954 -29.861 26.458  1.00 33.46 ? 955  MET   A SD  1 
ATOM   1911 C CE  . MET   A 1 262 ? -24.630 -29.177 28.013  1.00 30.89 ? 955  MET   A CE  1 
ATOM   1912 N N   . ILE   A 1 263 ? -21.384 -31.396 22.446  1.00 29.80 ? 956  ILE   A N   1 
ATOM   1913 C CA  . ILE   A 1 263 ? -21.023 -32.372 21.419  1.00 30.38 ? 956  ILE   A CA  1 
ATOM   1914 C C   . ILE   A 1 263 ? -22.173 -33.328 21.136  1.00 31.19 ? 956  ILE   A C   1 
ATOM   1915 O O   . ILE   A 1 263 ? -22.462 -33.628 19.960  1.00 31.16 ? 956  ILE   A O   1 
ATOM   1916 C CB  . ILE   A 1 263 ? -19.692 -33.071 21.777  1.00 30.51 ? 956  ILE   A CB  1 
ATOM   1917 C CG1 . ILE   A 1 263 ? -18.518 -32.065 21.714  1.00 31.28 ? 956  ILE   A CG1 1 
ATOM   1918 C CG2 . ILE   A 1 263 ? -19.425 -34.314 20.932  1.00 30.70 ? 956  ILE   A CG2 1 
ATOM   1919 C CD1 . ILE   A 1 263 ? -18.389 -31.263 20.430  1.00 32.27 ? 956  ILE   A CD1 1 
ATOM   1920 N N   . ASP   A 1 264 ? -22.875 -33.750 22.200  1.00 31.59 ? 957  ASP   A N   1 
ATOM   1921 C CA  . ASP   A 1 264 ? -24.034 -34.607 22.012  1.00 32.65 ? 957  ASP   A CA  1 
ATOM   1922 C C   . ASP   A 1 264 ? -25.170 -33.678 21.659  1.00 32.93 ? 957  ASP   A C   1 
ATOM   1923 O O   . ASP   A 1 264 ? -25.507 -32.815 22.458  1.00 32.91 ? 957  ASP   A O   1 
ATOM   1924 C CB  . ASP   A 1 264 ? -24.347 -35.409 23.274  1.00 35.10 ? 957  ASP   A CB  1 
ATOM   1925 C CG  . ASP   A 1 264 ? -25.290 -36.572 23.026  1.00 40.66 ? 957  ASP   A CG  1 
ATOM   1926 O OD1 . ASP   A 1 264 ? -24.898 -37.512 22.286  1.00 41.15 ? 957  ASP   A OD1 1 
ATOM   1927 O OD2 . ASP   A 1 264 ? -26.416 -36.550 23.577  1.00 43.61 ? 957  ASP   A OD2 1 
ATOM   1928 N N   . ALA   A 1 265 ? -25.691 -33.791 20.430  1.00 33.10 ? 958  ALA   A N   1 
ATOM   1929 C CA  . ALA   A 1 265 ? -26.741 -32.918 19.903  1.00 33.79 ? 958  ALA   A CA  1 
ATOM   1930 C C   . ALA   A 1 265 ? -28.021 -32.854 20.738  1.00 34.08 ? 958  ALA   A C   1 
ATOM   1931 O O   . ALA   A 1 265 ? -28.605 -31.778 20.885  1.00 34.25 ? 958  ALA   A O   1 
ATOM   1932 C CB  . ALA   A 1 265 ? -27.071 -33.313 18.475  1.00 34.22 ? 958  ALA   A CB  1 
ATOM   1933 N N   . ASP   A 1 266 ? -28.459 -33.999 21.280  1.00 33.84 ? 959  ASP   A N   1 
ATOM   1934 C CA  . ASP   A 1 266 ? -29.677 -34.073 22.100  1.00 33.76 ? 959  ASP   A CA  1 
ATOM   1935 C C   . ASP   A 1 266 ? -29.535 -33.368 23.440  1.00 33.30 ? 959  ASP   A C   1 
ATOM   1936 O O   . ASP   A 1 266 ? -30.530 -32.937 24.020  1.00 33.74 ? 959  ASP   A O   1 
ATOM   1937 C CB  . ASP   A 1 266 ? -30.113 -35.529 22.287  1.00 35.54 ? 959  ASP   A CB  1 
ATOM   1938 C CG  . ASP   A 1 266 ? -30.155 -36.269 20.965  1.00 41.07 ? 959  ASP   A CG  1 
ATOM   1939 O OD1 . ASP   A 1 266 ? -30.667 -35.687 19.970  1.00 41.01 ? 959  ASP   A OD1 1 
ATOM   1940 O OD2 . ASP   A 1 266 ? -29.642 -37.406 20.909  1.00 44.24 ? 959  ASP   A OD2 1 
ATOM   1941 N N   . SER   A 1 267 ? -28.297 -33.237 23.922  1.00 32.29 ? 960  SER   A N   1 
ATOM   1942 C CA  . SER   A 1 267 ? -27.953 -32.567 25.163  1.00 31.61 ? 960  SER   A CA  1 
ATOM   1943 C C   . SER   A 1 267 ? -28.067 -31.038 25.037  1.00 30.40 ? 960  SER   A C   1 
ATOM   1944 O O   . SER   A 1 267 ? -28.365 -30.377 26.022  1.00 30.63 ? 960  SER   A O   1 
ATOM   1945 C CB  . SER   A 1 267 ? -26.553 -32.984 25.596  1.00 33.23 ? 960  SER   A CB  1 
ATOM   1946 O OG  . SER   A 1 267 ? -26.445 -34.399 25.623  1.00 35.81 ? 960  SER   A OG  1 
ATOM   1947 N N   . ARG   A 1 268 ? -27.862 -30.481 23.831  1.00 29.31 ? 961  ARG   A N   1 
ATOM   1948 C CA  . ARG   A 1 268 ? -28.013 -29.048 23.552  1.00 28.56 ? 961  ARG   A CA  1 
ATOM   1949 C C   . ARG   A 1 268 ? -29.477 -28.648 23.786  1.00 27.73 ? 961  ARG   A C   1 
ATOM   1950 O O   . ARG   A 1 268 ? -30.375 -29.460 23.559  1.00 27.91 ? 961  ARG   A O   1 
ATOM   1951 C CB  . ARG   A 1 268 ? -27.662 -28.755 22.083  1.00 29.75 ? 961  ARG   A CB  1 
ATOM   1952 C CG  . ARG   A 1 268 ? -26.335 -29.311 21.623  1.00 32.29 ? 961  ARG   A CG  1 
ATOM   1953 C CD  . ARG   A 1 268 ? -26.307 -29.384 20.119  1.00 35.73 ? 961  ARG   A CD  1 
ATOM   1954 N NE  . ARG   A 1 268 ? -24.993 -29.788 19.632  1.00 39.29 ? 961  ARG   A NE  1 
ATOM   1955 C CZ  . ARG   A 1 268 ? -24.732 -30.160 18.382  1.00 42.02 ? 961  ARG   A CZ  1 
ATOM   1956 N NH1 . ARG   A 1 268 ? -25.700 -30.187 17.472  1.00 41.57 ? 961  ARG   A NH1 1 
ATOM   1957 N NH2 . ARG   A 1 268 ? -23.502 -30.516 18.034  1.00 42.35 ? 961  ARG   A NH2 1 
ATOM   1958 N N   . PRO   A 1 269 ? -29.754 -27.399 24.193  1.00 26.85 ? 962  PRO   A N   1 
ATOM   1959 C CA  . PRO   A 1 269 ? -31.147 -27.003 24.445  1.00 26.67 ? 962  PRO   A CA  1 
ATOM   1960 C C   . PRO   A 1 269 ? -32.065 -27.134 23.247  1.00 27.10 ? 962  PRO   A C   1 
ATOM   1961 O O   . PRO   A 1 269 ? -31.596 -27.212 22.114  1.00 28.03 ? 962  PRO   A O   1 
ATOM   1962 C CB  . PRO   A 1 269 ? -31.036 -25.537 24.878  1.00 27.23 ? 962  PRO   A CB  1 
ATOM   1963 C CG  . PRO   A 1 269 ? -29.679 -25.109 24.514  1.00 27.68 ? 962  PRO   A CG  1 
ATOM   1964 C CD  . PRO   A 1 269 ? -28.817 -26.315 24.521  1.00 26.22 ? 962  PRO   A CD  1 
ATOM   1965 N N   . LYS   A 1 270 ? -33.368 -27.175 23.486  1.00 26.64 ? 963  LYS   A N   1 
ATOM   1966 C CA  . LYS   A 1 270 ? -34.333 -27.245 22.392  1.00 27.13 ? 963  LYS   A CA  1 
ATOM   1967 C C   . LYS   A 1 270 ? -34.866 -25.835 22.112  1.00 28.17 ? 963  LYS   A C   1 
ATOM   1968 O O   . LYS   A 1 270 ? -34.802 -24.973 22.995  1.00 28.02 ? 963  LYS   A O   1 
ATOM   1969 C CB  . LYS   A 1 270 ? -35.446 -28.266 22.679  1.00 27.84 ? 963  LYS   A CB  1 
ATOM   1970 C CG  . LYS   A 1 270 ? -35.152 -29.683 22.161  1.00 29.90 ? 963  LYS   A CG  1 
ATOM   1971 C CD  . LYS   A 1 270 ? -33.845 -30.294 22.703  1.00 32.95 ? 963  LYS   A CD  1 
ATOM   1972 C CE  . LYS   A 1 270 ? -34.009 -31.682 23.290  1.00 36.23 ? 963  LYS   A CE  1 
ATOM   1973 N NZ  . LYS   A 1 270 ? -33.554 -31.757 24.715  1.00 37.73 ? 963  LYS   A NZ  1 
ATOM   1974 N N   . PHE   A 1 271 ? -35.358 -25.576 20.884  1.00 28.92 ? 964  PHE   A N   1 
ATOM   1975 C CA  . PHE   A 1 271 ? -35.844 -24.234 20.535  1.00 30.03 ? 964  PHE   A CA  1 
ATOM   1976 C C   . PHE   A 1 271 ? -37.038 -23.775 21.382  1.00 30.87 ? 964  PHE   A C   1 
ATOM   1977 O O   . PHE   A 1 271 ? -37.216 -22.573 21.566  1.00 31.01 ? 964  PHE   A O   1 
ATOM   1978 C CB  . PHE   A 1 271 ? -36.129 -24.100 19.036  1.00 30.17 ? 964  PHE   A CB  1 
ATOM   1979 C CG  . PHE   A 1 271 ? -34.882 -23.780 18.248  1.00 30.94 ? 964  PHE   A CG  1 
ATOM   1980 C CD1 . PHE   A 1 271 ? -34.128 -22.660 18.541  1.00 31.81 ? 964  PHE   A CD1 1 
ATOM   1981 C CD2 . PHE   A 1 271 ? -34.458 -24.605 17.223  1.00 31.71 ? 964  PHE   A CD2 1 
ATOM   1982 C CE1 . PHE   A 1 271 ? -32.973 -22.378 17.829  1.00 32.54 ? 964  PHE   A CE1 1 
ATOM   1983 C CE2 . PHE   A 1 271 ? -33.312 -24.306 16.497  1.00 32.40 ? 964  PHE   A CE2 1 
ATOM   1984 C CZ  . PHE   A 1 271 ? -32.566 -23.207 16.817  1.00 32.21 ? 964  PHE   A CZ  1 
ATOM   1985 N N   . ARG   A 1 272 ? -37.817 -24.725 21.937  1.00 31.11 ? 965  ARG   A N   1 
ATOM   1986 C CA  . ARG   A 1 272 ? -38.928 -24.426 22.847  1.00 31.43 ? 965  ARG   A CA  1 
ATOM   1987 C C   . ARG   A 1 272 ? -38.359 -23.898 24.159  1.00 30.79 ? 965  ARG   A C   1 
ATOM   1988 O O   . ARG   A 1 272 ? -38.891 -22.948 24.717  1.00 30.92 ? 965  ARG   A O   1 
ATOM   1989 C CB  . ARG   A 1 272 ? -39.768 -25.691 23.130  1.00 33.79 ? 965  ARG   A CB  1 
ATOM   1990 C CG  . ARG   A 1 272 ? -40.893 -25.945 22.131  1.00 39.08 ? 965  ARG   A CG  1 
ATOM   1991 C CD  . ARG   A 1 272 ? -42.118 -26.554 22.800  1.00 44.08 ? 965  ARG   A CD  1 
ATOM   1992 N NE  . ARG   A 1 272 ? -43.325 -25.747 22.583  1.00 48.72 ? 965  ARG   A NE  1 
ATOM   1993 C CZ  . ARG   A 1 272 ? -43.963 -25.072 23.539  1.00 51.96 ? 965  ARG   A CZ  1 
ATOM   1994 N NH1 . ARG   A 1 272 ? -43.524 -25.107 24.794  1.00 51.60 ? 965  ARG   A NH1 1 
ATOM   1995 N NH2 . ARG   A 1 272 ? -45.046 -24.361 23.248  1.00 52.24 ? 965  ARG   A NH2 1 
ATOM   1996 N N   . GLU   A 1 273 ? -37.274 -24.529 24.646  1.00 30.12 ? 966  GLU   A N   1 
ATOM   1997 C CA  . GLU   A 1 273 ? -36.573 -24.205 25.882  1.00 29.78 ? 966  GLU   A CA  1 
ATOM   1998 C C   . GLU   A 1 273 ? -35.813 -22.895 25.776  1.00 29.88 ? 966  GLU   A C   1 
ATOM   1999 O O   . GLU   A 1 273 ? -35.670 -22.204 26.781  1.00 29.85 ? 966  GLU   A O   1 
ATOM   2000 C CB  . GLU   A 1 273 ? -35.592 -25.331 26.235  1.00 31.32 ? 966  GLU   A CB  1 
ATOM   2001 C CG  . GLU   A 1 273 ? -36.210 -26.718 26.256  1.00 34.86 ? 966  GLU   A CG  1 
ATOM   2002 C CD  . GLU   A 1 273 ? -35.233 -27.831 26.580  1.00 39.98 ? 966  GLU   A CD  1 
ATOM   2003 O OE1 . GLU   A 1 273 ? -34.248 -27.572 27.311  1.00 40.74 ? 966  GLU   A OE1 1 
ATOM   2004 O OE2 . GLU   A 1 273 ? -35.441 -28.960 26.080  1.00 41.95 ? 966  GLU   A OE2 1 
ATOM   2005 N N   . LEU   A 1 274 ? -35.294 -22.565 24.569  1.00 30.01 ? 967  LEU   A N   1 
ATOM   2006 C CA  . LEU   A 1 274 ? -34.548 -21.323 24.306  1.00 30.36 ? 967  LEU   A CA  1 
ATOM   2007 C C   . LEU   A 1 274 ? -35.462 -20.100 24.366  1.00 30.71 ? 967  LEU   A C   1 
ATOM   2008 O O   . LEU   A 1 274 ? -35.132 -19.117 25.038  1.00 30.36 ? 967  LEU   A O   1 
ATOM   2009 C CB  . LEU   A 1 274 ? -33.818 -21.406 22.966  1.00 30.25 ? 967  LEU   A CB  1 
ATOM   2010 C CG  . LEU   A 1 274 ? -32.688 -22.413 22.951  1.00 31.31 ? 967  LEU   A CG  1 
ATOM   2011 C CD1 . LEU   A 1 274 ? -32.180 -22.634 21.553  1.00 31.53 ? 967  LEU   A CD1 1 
ATOM   2012 C CD2 . LEU   A 1 274 ? -31.569 -21.987 23.889  1.00 31.81 ? 967  LEU   A CD2 1 
ATOM   2013 N N   . ILE   A 1 275 ? -36.653 -20.203 23.724  1.00 30.92 ? 968  ILE   A N   1 
ATOM   2014 C CA  . ILE   A 1 275 ? -37.726 -19.205 23.746  1.00 31.70 ? 968  ILE   A CA  1 
ATOM   2015 C C   . ILE   A 1 275 ? -38.091 -18.903 25.211  1.00 32.43 ? 968  ILE   A C   1 
ATOM   2016 O O   . ILE   A 1 275 ? -38.225 -17.745 25.581  1.00 32.50 ? 968  ILE   A O   1 
ATOM   2017 C CB  . ILE   A 1 275 ? -38.958 -19.770 22.972  1.00 32.20 ? 968  ILE   A CB  1 
ATOM   2018 C CG1 . ILE   A 1 275 ? -38.789 -19.626 21.466  1.00 33.31 ? 968  ILE   A CG1 1 
ATOM   2019 C CG2 . ILE   A 1 275 ? -40.301 -19.158 23.438  1.00 32.75 ? 968  ILE   A CG2 1 
ATOM   2020 C CD1 . ILE   A 1 275 ? -39.847 -20.391 20.690  1.00 34.78 ? 968  ILE   A CD1 1 
ATOM   2021 N N   . ILE   A 1 276 ? -38.226 -19.968 26.025  1.00 32.95 ? 969  ILE   A N   1 
ATOM   2022 C CA  . ILE   A 1 276 ? -38.583 -19.946 27.441  1.00 33.85 ? 969  ILE   A CA  1 
ATOM   2023 C C   . ILE   A 1 276 ? -37.504 -19.247 28.279  1.00 34.37 ? 969  ILE   A C   1 
ATOM   2024 O O   . ILE   A 1 276 ? -37.825 -18.303 28.989  1.00 34.40 ? 969  ILE   A O   1 
ATOM   2025 C CB  . ILE   A 1 276 ? -38.937 -21.404 27.920  1.00 34.36 ? 969  ILE   A CB  1 
ATOM   2026 C CG1 . ILE   A 1 276 ? -40.454 -21.583 28.131  1.00 35.42 ? 969  ILE   A CG1 1 
ATOM   2027 C CG2 . ILE   A 1 276 ? -38.146 -21.897 29.137  1.00 34.58 ? 969  ILE   A CG2 1 
ATOM   2028 C CD1 . ILE   A 1 276 ? -41.266 -21.915 26.847  1.00 36.58 ? 969  ILE   A CD1 1 
ATOM   2029 N N   . GLU   A 1 277 ? -36.238 -19.682 28.169  1.00 34.67 ? 970  GLU   A N   1 
ATOM   2030 C CA  . GLU   A 1 277 ? -35.145 -19.103 28.938  1.00 35.40 ? 970  GLU   A CA  1 
ATOM   2031 C C   . GLU   A 1 277 ? -34.914 -17.650 28.571  1.00 35.35 ? 970  GLU   A C   1 
ATOM   2032 O O   . GLU   A 1 277 ? -34.722 -16.826 29.461  1.00 35.76 ? 970  GLU   A O   1 
ATOM   2033 C CB  . GLU   A 1 277 ? -33.849 -19.912 28.765  1.00 38.71 ? 970  GLU   A CB  1 
ATOM   2034 C CG  . GLU   A 1 277 ? -33.381 -20.598 30.034  1.00 46.41 ? 970  GLU   A CG  1 
ATOM   2035 C CD  . GLU   A 1 277 ? -33.113 -19.670 31.206  1.00 57.69 ? 970  GLU   A CD  1 
ATOM   2036 O OE1 . GLU   A 1 277 ? -32.608 -18.546 30.973  1.00 59.92 ? 970  GLU   A OE1 1 
ATOM   2037 O OE2 . GLU   A 1 277 ? -33.397 -20.068 32.362  1.00 61.33 ? 970  GLU   A OE2 1 
ATOM   2038 N N   . PHE   A 1 278 ? -34.943 -17.329 27.274  1.00 34.79 ? 971  PHE   A N   1 
ATOM   2039 C CA  . PHE   A 1 278 ? -34.721 -15.956 26.837  1.00 34.57 ? 971  PHE   A CA  1 
ATOM   2040 C C   . PHE   A 1 278 ? -35.901 -15.048 27.116  1.00 34.84 ? 971  PHE   A C   1 
ATOM   2041 O O   . PHE   A 1 278 ? -35.698 -13.870 27.378  1.00 34.87 ? 971  PHE   A O   1 
ATOM   2042 C CB  . PHE   A 1 278 ? -34.298 -15.895 25.379  1.00 33.94 ? 971  PHE   A CB  1 
ATOM   2043 C CG  . PHE   A 1 278 ? -32.822 -16.122 25.183  1.00 34.07 ? 971  PHE   A CG  1 
ATOM   2044 C CD1 . PHE   A 1 278 ? -31.913 -15.103 25.410  1.00 34.58 ? 971  PHE   A CD1 1 
ATOM   2045 C CD2 . PHE   A 1 278 ? -32.344 -17.348 24.754  1.00 34.64 ? 971  PHE   A CD2 1 
ATOM   2046 C CE1 . PHE   A 1 278 ? -30.554 -15.307 25.211  1.00 35.12 ? 971  PHE   A CE1 1 
ATOM   2047 C CE2 . PHE   A 1 278 ? -30.989 -17.544 24.541  1.00 35.23 ? 971  PHE   A CE2 1 
ATOM   2048 C CZ  . PHE   A 1 278 ? -30.100 -16.526 24.783  1.00 34.96 ? 971  PHE   A CZ  1 
ATOM   2049 N N   . SER   A 1 279 ? -37.125 -15.590 27.123  1.00 34.91 ? 972  SER   A N   1 
ATOM   2050 C CA  . SER   A 1 279 ? -38.309 -14.794 27.445  1.00 35.45 ? 972  SER   A CA  1 
ATOM   2051 C C   . SER   A 1 279 ? -38.219 -14.307 28.900  1.00 36.28 ? 972  SER   A C   1 
ATOM   2052 O O   . SER   A 1 279 ? -38.571 -13.164 29.185  1.00 36.64 ? 972  SER   A O   1 
ATOM   2053 C CB  . SER   A 1 279 ? -39.589 -15.603 27.231  1.00 36.22 ? 972  SER   A CB  1 
ATOM   2054 O OG  . SER   A 1 279 ? -39.844 -15.874 25.861  1.00 37.63 ? 972  SER   A OG  1 
ATOM   2055 N N   . LYS   A 1 280 ? -37.713 -15.172 29.805  1.00 36.38 ? 973  LYS   A N   1 
ATOM   2056 C CA  . LYS   A 1 280 ? -37.501 -14.884 31.220  1.00 36.83 ? 973  LYS   A CA  1 
ATOM   2057 C C   . LYS   A 1 280 ? -36.460 -13.779 31.395  1.00 37.54 ? 973  LYS   A C   1 
ATOM   2058 O O   . LYS   A 1 280 ? -36.577 -12.953 32.306  1.00 37.93 ? 973  LYS   A O   1 
ATOM   2059 C CB  . LYS   A 1 280 ? -36.975 -16.138 31.934  1.00 38.21 ? 973  LYS   A CB  1 
ATOM   2060 C CG  . LYS   A 1 280 ? -37.986 -17.247 32.164  1.00 41.34 ? 973  LYS   A CG  1 
ATOM   2061 C CD  . LYS   A 1 280 ? -37.300 -18.541 32.646  1.00 44.37 ? 973  LYS   A CD  1 
ATOM   2062 C CE  . LYS   A 1 280 ? -36.462 -18.387 33.901  1.00 46.74 ? 973  LYS   A CE  1 
ATOM   2063 N NZ  . LYS   A 1 280 ? -35.011 -18.226 33.597  1.00 48.00 ? 973  LYS   A NZ  1 
ATOM   2064 N N   . MET   A 1 281 ? -35.416 -13.796 30.554  1.00 37.56 ? 974  MET   A N   1 
ATOM   2065 C CA  . MET   A 1 281 ? -34.337 -12.832 30.619  1.00 38.29 ? 974  MET   A CA  1 
ATOM   2066 C C   . MET   A 1 281 ? -34.732 -11.442 30.149  1.00 39.60 ? 974  MET   A C   1 
ATOM   2067 O O   . MET   A 1 281 ? -34.227 -10.449 30.668  1.00 39.49 ? 974  MET   A O   1 
ATOM   2068 C CB  . MET   A 1 281 ? -33.122 -13.357 29.871  1.00 38.39 ? 974  MET   A CB  1 
ATOM   2069 C CG  . MET   A 1 281 ? -32.547 -14.571 30.512  1.00 39.82 ? 974  MET   A CG  1 
ATOM   2070 S SD  . MET   A 1 281 ? -31.179 -15.245 29.566  1.00 43.53 ? 974  MET   A SD  1 
ATOM   2071 C CE  . MET   A 1 281 ? -30.262 -15.994 30.873  1.00 43.12 ? 974  MET   A CE  1 
ATOM   2072 N N   . ALA   A 1 282 ? -35.654 -11.372 29.183  1.00 40.63 ? 975  ALA   A N   1 
ATOM   2073 C CA  . ALA   A 1 282 ? -36.170 -10.114 28.644  1.00 42.00 ? 975  ALA   A CA  1 
ATOM   2074 C C   . ALA   A 1 282 ? -36.984 -9.322  29.672  1.00 43.57 ? 975  ALA   A C   1 
ATOM   2075 O O   . ALA   A 1 282 ? -37.139 -8.114  29.509  1.00 43.76 ? 975  ALA   A O   1 
ATOM   2076 C CB  . ALA   A 1 282 ? -37.029 -10.390 27.421  1.00 42.03 ? 975  ALA   A CB  1 
ATOM   2077 N N   . ARG   A 1 283 ? -37.529 -10.002 30.705  1.00 44.50 ? 976  ARG   A N   1 
ATOM   2078 C CA  . ARG   A 1 283 ? -38.329 -9.379  31.757  1.00 45.95 ? 976  ARG   A CA  1 
ATOM   2079 C C   . ARG   A 1 283 ? -37.475 -8.380  32.549  1.00 46.86 ? 976  ARG   A C   1 
ATOM   2080 O O   . ARG   A 1 283 ? -37.935 -7.275  32.840  1.00 47.20 ? 976  ARG   A O   1 
ATOM   2081 C CB  . ARG   A 1 283 ? -38.964 -10.449 32.663  1.00 47.81 ? 976  ARG   A CB  1 
ATOM   2082 C CG  . ARG   A 1 283 ? -39.701 -11.530 31.872  1.00 51.63 ? 976  ARG   A CG  1 
ATOM   2083 C CD  . ARG   A 1 283 ? -40.858 -12.146 32.642  1.00 55.60 ? 976  ARG   A CD  1 
ATOM   2084 N NE  . ARG   A 1 283 ? -40.983 -13.592 32.426  1.00 58.83 ? 976  ARG   A NE  1 
ATOM   2085 C CZ  . ARG   A 1 283 ? -41.625 -14.149 31.400  1.00 60.50 ? 976  ARG   A CZ  1 
ATOM   2086 N NH1 . ARG   A 1 283 ? -41.692 -15.471 31.291  1.00 59.59 ? 976  ARG   A NH1 1 
ATOM   2087 N NH2 . ARG   A 1 283 ? -42.198 -13.389 30.472  1.00 60.23 ? 976  ARG   A NH2 1 
ATOM   2088 N N   . ASP   A 1 284 ? -36.213 -8.744  32.839  1.00 46.96 ? 977  ASP   A N   1 
ATOM   2089 C CA  . ASP   A 1 284 ? -35.252 -7.859  33.504  1.00 47.40 ? 977  ASP   A CA  1 
ATOM   2090 C C   . ASP   A 1 284 ? -33.939 -7.947  32.718  1.00 47.45 ? 977  ASP   A C   1 
ATOM   2091 O O   . ASP   A 1 284 ? -33.042 -8.686  33.109  1.00 47.81 ? 977  ASP   A O   1 
ATOM   2092 C CB  . ASP   A 1 284 ? -35.033 -8.288  34.964  1.00 49.15 ? 977  ASP   A CB  1 
ATOM   2093 C CG  . ASP   A 1 284 ? -34.237 -7.311  35.812  1.00 53.85 ? 977  ASP   A CG  1 
ATOM   2094 O OD1 . ASP   A 1 284 ? -33.908 -6.208  35.307  1.00 54.61 ? 977  ASP   A OD1 1 
ATOM   2095 O OD2 . ASP   A 1 284 ? -33.954 -7.640  36.989  1.00 55.95 ? 977  ASP   A OD2 1 
ATOM   2096 N N   . PRO   A 1 285 ? -33.823 -7.235  31.582  1.00 46.82 ? 978  PRO   A N   1 
ATOM   2097 C CA  . PRO   A 1 285 ? -32.616 -7.372  30.752  1.00 46.56 ? 978  PRO   A CA  1 
ATOM   2098 C C   . PRO   A 1 285 ? -31.299 -6.919  31.383  1.00 46.38 ? 978  PRO   A C   1 
ATOM   2099 O O   . PRO   A 1 285 ? -30.254 -7.472  31.063  1.00 46.09 ? 978  PRO   A O   1 
ATOM   2100 C CB  . PRO   A 1 285 ? -32.951 -6.563  29.494  1.00 47.18 ? 978  PRO   A CB  1 
ATOM   2101 C CG  . PRO   A 1 285 ? -34.036 -5.643  29.896  1.00 47.59 ? 978  PRO   A CG  1 
ATOM   2102 C CD  . PRO   A 1 285 ? -34.816 -6.340  30.958  1.00 46.18 ? 978  PRO   A CD  1 
ATOM   2103 N N   . GLN   A 1 286 ? -31.340 -5.941  32.279  1.00 46.52 ? 979  GLN   A N   1 
ATOM   2104 C CA  . GLN   A 1 286 ? -30.131 -5.436  32.936  1.00 47.23 ? 979  GLN   A CA  1 
ATOM   2105 C C   . GLN   A 1 286 ? -29.452 -6.461  33.874  1.00 46.91 ? 979  GLN   A C   1 
ATOM   2106 O O   . GLN   A 1 286 ? -28.265 -6.341  34.181  1.00 46.79 ? 979  GLN   A O   1 
ATOM   2107 C CB  . GLN   A 1 286 ? -30.428 -4.115  33.670  1.00 49.37 ? 979  GLN   A CB  1 
ATOM   2108 C CG  . GLN   A 1 286 ? -30.820 -2.965  32.732  1.00 52.95 ? 979  GLN   A CG  1 
ATOM   2109 C CD  . GLN   A 1 286 ? -32.287 -2.899  32.350  1.00 57.11 ? 979  GLN   A CD  1 
ATOM   2110 O OE1 . GLN   A 1 286 ? -32.667 -2.176  31.421  1.00 58.78 ? 979  GLN   A OE1 1 
ATOM   2111 N NE2 . GLN   A 1 286 ? -33.150 -3.639  33.048  1.00 57.42 ? 979  GLN   A NE2 1 
ATOM   2112 N N   . ARG   A 1 287 ? -30.204 -7.463  34.319  1.00 46.66 ? 980  ARG   A N   1 
ATOM   2113 C CA  . ARG   A 1 287 ? -29.671 -8.512  35.175  1.00 47.08 ? 980  ARG   A CA  1 
ATOM   2114 C C   . ARG   A 1 287 ? -28.872 -9.527  34.358  1.00 46.89 ? 980  ARG   A C   1 
ATOM   2115 O O   . ARG   A 1 287 ? -27.915 -10.101 34.866  1.00 47.18 ? 980  ARG   A O   1 
ATOM   2116 C CB  . ARG   A 1 287 ? -30.829 -9.230  35.891  1.00 48.99 ? 980  ARG   A CB  1 
ATOM   2117 C CG  . ARG   A 1 287 ? -30.412 -10.172 37.026  1.00 52.67 ? 980  ARG   A CG  1 
ATOM   2118 C CD  . ARG   A 1 287 ? -31.503 -11.182 37.375  1.00 56.41 ? 980  ARG   A CD  1 
ATOM   2119 N NE  . ARG   A 1 287 ? -32.793 -10.544 37.661  1.00 59.93 ? 980  ARG   A NE  1 
ATOM   2120 C CZ  . ARG   A 1 287 ? -33.976 -11.127 37.482  1.00 62.52 ? 980  ARG   A CZ  1 
ATOM   2121 N NH1 . ARG   A 1 287 ? -34.049 -12.367 37.010  1.00 62.12 ? 980  ARG   A NH1 1 
ATOM   2122 N NH2 . ARG   A 1 287 ? -35.095 -10.469 37.758  1.00 62.77 ? 980  ARG   A NH2 1 
ATOM   2123 N N   . TYR   A 1 288 ? -29.268 -9.760  33.102  1.00 46.38 ? 981  TYR   A N   1 
ATOM   2124 C CA  . TYR   A 1 288 ? -28.646 -10.762 32.240  1.00 46.28 ? 981  TYR   A CA  1 
ATOM   2125 C C   . TYR   A 1 288 ? -27.652 -10.183 31.232  1.00 45.77 ? 981  TYR   A C   1 
ATOM   2126 O O   . TYR   A 1 288 ? -26.748 -10.893 30.807  1.00 45.73 ? 981  TYR   A O   1 
ATOM   2127 C CB  . TYR   A 1 288 ? -29.724 -11.603 31.553  1.00 46.31 ? 981  TYR   A CB  1 
ATOM   2128 C CG  . TYR   A 1 288 ? -30.682 -12.219 32.548  1.00 47.29 ? 981  TYR   A CG  1 
ATOM   2129 C CD1 . TYR   A 1 288 ? -30.329 -13.347 33.275  1.00 48.38 ? 981  TYR   A CD1 1 
ATOM   2130 C CD2 . TYR   A 1 288 ? -31.895 -11.617 32.836  1.00 48.17 ? 981  TYR   A CD2 1 
ATOM   2131 C CE1 . TYR   A 1 288 ? -31.198 -13.907 34.204  1.00 49.26 ? 981  TYR   A CE1 1 
ATOM   2132 C CE2 . TYR   A 1 288 ? -32.766 -12.158 33.771  1.00 49.08 ? 981  TYR   A CE2 1 
ATOM   2133 C CZ  . TYR   A 1 288 ? -32.421 -13.313 34.443  1.00 50.14 ? 981  TYR   A CZ  1 
ATOM   2134 O OH  . TYR   A 1 288 ? -33.294 -13.856 35.350  1.00 51.96 ? 981  TYR   A OH  1 
ATOM   2135 N N   . LEU   A 1 289 ? -27.779 -8.892  30.887  1.00 45.13 ? 982  LEU   A N   1 
ATOM   2136 C CA  . LEU   A 1 289 ? -26.839 -8.238  29.978  1.00 45.03 ? 982  LEU   A CA  1 
ATOM   2137 C C   . LEU   A 1 289 ? -26.368 -6.914  30.551  1.00 45.14 ? 982  LEU   A C   1 
ATOM   2138 O O   . LEU   A 1 289 ? -27.186 -6.060  30.898  1.00 45.00 ? 982  LEU   A O   1 
ATOM   2139 C CB  . LEU   A 1 289 ? -27.433 -8.031  28.579  1.00 44.92 ? 982  LEU   A CB  1 
ATOM   2140 C CG  . LEU   A 1 289 ? -27.488 -9.245  27.672  1.00 45.70 ? 982  LEU   A CG  1 
ATOM   2141 C CD1 . LEU   A 1 289 ? -28.108 -8.875  26.362  1.00 46.34 ? 982  LEU   A CD1 1 
ATOM   2142 C CD2 . LEU   A 1 289 ? -26.108 -9.822  27.441  1.00 45.95 ? 982  LEU   A CD2 1 
ATOM   2143 N N   . VAL   A 1 290 ? -25.045 -6.741  30.634  1.00 45.33 ? 983  VAL   A N   1 
ATOM   2144 C CA  . VAL   A 1 290 ? -24.437 -5.544  31.204  1.00 46.13 ? 983  VAL   A CA  1 
ATOM   2145 C C   . VAL   A 1 290 ? -23.833 -4.629  30.132  1.00 46.76 ? 983  VAL   A C   1 
ATOM   2146 O O   . VAL   A 1 290 ? -22.653 -4.736  29.793  1.00 46.28 ? 983  VAL   A O   1 
ATOM   2147 C CB  . VAL   A 1 290 ? -23.422 -5.852  32.341  1.00 46.81 ? 983  VAL   A CB  1 
ATOM   2148 C CG1 . VAL   A 1 290 ? -23.153 -4.603  33.170  1.00 47.29 ? 983  VAL   A CG1 1 
ATOM   2149 C CG2 . VAL   A 1 290 ? -23.905 -6.992  33.242  1.00 47.20 ? 983  VAL   A CG2 1 
ATOM   2150 N N   . ILE   A 1 291 ? -24.667 -3.712  29.628  1.00 47.80 ? 984  ILE   A N   1 
ATOM   2151 C CA  . ILE   A 1 291 ? -24.353 -2.697  28.620  1.00 49.44 ? 984  ILE   A CA  1 
ATOM   2152 C C   . ILE   A 1 291 ? -24.391 -1.315  29.288  1.00 50.98 ? 984  ILE   A C   1 
ATOM   2153 O O   . ILE   A 1 291 ? -25.217 -1.099  30.176  1.00 51.52 ? 984  ILE   A O   1 
ATOM   2154 C CB  . ILE   A 1 291 ? -25.410 -2.808  27.481  1.00 50.17 ? 984  ILE   A CB  1 
ATOM   2155 C CG1 . ILE   A 1 291 ? -25.069 -3.943  26.511  1.00 51.15 ? 984  ILE   A CG1 1 
ATOM   2156 C CG2 . ILE   A 1 291 ? -25.634 -1.497  26.722  1.00 50.84 ? 984  ILE   A CG2 1 
ATOM   2157 C CD1 . ILE   A 1 291 ? -25.964 -5.123  26.625  1.00 52.57 ? 984  ILE   A CD1 1 
ATOM   2158 N N   . GLN   A 1 292 ? -23.525 -0.376  28.866  1.00 51.59 ? 985  GLN   A N   1 
ATOM   2159 C CA  . GLN   A 1 292 ? -23.549 0.973   29.440  1.00 52.73 ? 985  GLN   A CA  1 
ATOM   2160 C C   . GLN   A 1 292 ? -24.701 1.759   28.794  1.00 53.43 ? 985  GLN   A C   1 
ATOM   2161 O O   . GLN   A 1 292 ? -24.638 2.078   27.606  1.00 53.16 ? 985  GLN   A O   1 
ATOM   2162 C CB  . GLN   A 1 292 ? -22.216 1.706   29.207  1.00 54.63 ? 985  GLN   A CB  1 
ATOM   2163 C CG  . GLN   A 1 292 ? -20.966 0.861   29.444  1.00 58.40 ? 985  GLN   A CG  1 
ATOM   2164 C CD  . GLN   A 1 292 ? -19.897 1.152   28.412  1.00 63.45 ? 985  GLN   A CD  1 
ATOM   2165 O OE1 . GLN   A 1 292 ? -19.382 0.248   27.737  1.00 64.80 ? 985  GLN   A OE1 1 
ATOM   2166 N NE2 . GLN   A 1 292 ? -19.548 2.426   28.254  1.00 64.33 ? 985  GLN   A NE2 1 
ATOM   2167 N N   . GLY   A 1 293 ? -25.748 2.040   29.567  1.00 53.92 ? 986  GLY   A N   1 
ATOM   2168 C CA  . GLY   A 1 293 ? -26.892 2.788   29.052  1.00 54.76 ? 986  GLY   A CA  1 
ATOM   2169 C C   . GLY   A 1 293 ? -28.259 2.350   29.548  1.00 55.25 ? 986  GLY   A C   1 
ATOM   2170 O O   . GLY   A 1 293 ? -29.277 2.904   29.125  1.00 55.23 ? 986  GLY   A O   1 
ATOM   2171 N N   . ASP   A 1 294 ? -28.302 1.361   30.448  1.00 55.54 ? 987  ASP   A N   1 
ATOM   2172 C CA  . ASP   A 1 294 ? -29.569 0.862   30.988  1.00 56.21 ? 987  ASP   A CA  1 
ATOM   2173 C C   . ASP   A 1 294 ? -29.464 0.417   32.455  1.00 56.61 ? 987  ASP   A C   1 
ATOM   2174 O O   . ASP   A 1 294 ? -29.955 1.104   33.355  1.00 56.72 ? 987  ASP   A O   1 
ATOM   2175 C CB  . ASP   A 1 294 ? -30.176 -0.251  30.096  1.00 57.81 ? 987  ASP   A CB  1 
ATOM   2176 C CG  . ASP   A 1 294 ? -29.193 -1.249  29.498  1.00 61.23 ? 987  ASP   A CG  1 
ATOM   2177 O OD1 . ASP   A 1 294 ? -28.816 -2.216  30.208  1.00 61.96 ? 987  ASP   A OD1 1 
ATOM   2178 O OD2 . ASP   A 1 294 ? -28.828 -1.085  28.312  1.00 62.16 ? 987  ASP   A OD2 1 
HETATM 2179 C C1  . A1H7N B 2 .   ? -26.668 -8.340  4.152   1.00 31.84 ? 1101 A1H7N A C1  1 
HETATM 2180 C C2  . A1H7N B 2 .   ? -26.698 -9.847  4.101   1.00 31.60 ? 1101 A1H7N A C2  1 
HETATM 2181 C C3  . A1H7N B 2 .   ? -27.957 -11.797 3.206   1.00 30.36 ? 1101 A1H7N A C3  1 
HETATM 2182 C C7  . A1H7N B 2 .   ? -32.109 -11.918 -1.089  1.00 30.33 ? 1101 A1H7N A C7  1 
HETATM 2183 C C8  . A1H7N B 2 .   ? -33.039 -12.443 -1.971  1.00 30.53 ? 1101 A1H7N A C8  1 
HETATM 2184 C C9  . A1H7N B 2 .   ? -33.779 -13.560 -1.621  1.00 30.64 ? 1101 A1H7N A C9  1 
HETATM 2185 C C10 . A1H7N B 2 .   ? -33.589 -14.158 -0.379  1.00 30.49 ? 1101 A1H7N A C10 1 
HETATM 2186 C C11 . A1H7N B 2 .   ? -32.653 -13.629 0.508   1.00 30.32 ? 1101 A1H7N A C11 1 
HETATM 2187 C C12 . A1H7N B 2 .   ? -34.352 -15.316 -0.006  1.00 30.50 ? 1101 A1H7N A C12 1 
HETATM 2188 C C13 . A1H7N B 2 .   ? -34.959 -16.279 0.364   1.00 30.99 ? 1101 A1H7N A C13 1 
HETATM 2189 C C14 . A1H7N B 2 .   ? -35.688 -17.411 0.824   1.00 31.78 ? 1101 A1H7N A C14 1 
HETATM 2190 C C15 . A1H7N B 2 .   ? -37.416 -18.224 2.006   1.00 32.23 ? 1101 A1H7N A C15 1 
HETATM 2191 C C16 . A1H7N B 2 .   ? -37.048 -19.512 1.686   1.00 32.60 ? 1101 A1H7N A C16 1 
HETATM 2192 C C19 . A1H7N B 2 .   ? -29.089 -9.707  3.431   1.00 30.35 ? 1101 A1H7N A C19 1 
HETATM 2193 C C20 . A1H7N B 2 .   ? -31.943 -9.672  1.496   1.00 30.37 ? 1101 A1H7N A C20 1 
HETATM 2194 C C21 . A1H7N B 2 .   ? -33.289 -9.948  1.651   1.00 30.32 ? 1101 A1H7N A C21 1 
HETATM 2195 C C22 . A1H7N B 2 .   ? -34.200 -8.927  1.468   1.00 30.12 ? 1101 A1H7N A C22 1 
HETATM 2196 C C24 . A1H7N B 2 .   ? -31.565 -8.384  1.163   1.00 30.38 ? 1101 A1H7N A C24 1 
HETATM 2197 O O   . A1H7N B 2 .   ? -25.748 -10.517 4.476   1.00 31.93 ? 1101 A1H7N A O   1 
HETATM 2198 C C   . A1H7N B 2 .   ? -27.162 -7.796  5.473   1.00 31.94 ? 1101 A1H7N A C   1 
HETATM 2199 N N   . A1H7N B 2 .   ? -27.825 -10.406 3.618   1.00 30.77 ? 1101 A1H7N A N   1 
HETATM 2200 C C18 . A1H7N B 2 .   ? -29.836 -10.602 2.493   1.00 30.25 ? 1101 A1H7N A C18 1 
HETATM 2201 C C4  . A1H7N B 2 .   ? -29.182 -11.796 2.369   1.00 30.17 ? 1101 A1H7N A C4  1 
HETATM 2202 N N4  . A1H7N B 2 .   ? -30.956 -10.703 1.677   1.00 30.31 ? 1101 A1H7N A N4  1 
HETATM 2203 C C23 . A1H7N B 2 .   ? -32.548 -7.427  1.000   1.00 30.35 ? 1101 A1H7N A C23 1 
HETATM 2204 N N5  . A1H7N B 2 .   ? -33.854 -7.675  1.146   1.00 30.22 ? 1101 A1H7N A N5  1 
HETATM 2205 C C5  . A1H7N B 2 .   ? -30.921 -11.957 1.099   1.00 30.12 ? 1101 A1H7N A C5  1 
HETATM 2206 N N1  . A1H7N B 2 .   ? -29.858 -12.631 1.505   1.00 29.99 ? 1101 A1H7N A N1  1 
HETATM 2207 C C6  . A1H7N B 2 .   ? -31.909 -12.506 0.155   1.00 30.20 ? 1101 A1H7N A C6  1 
HETATM 2208 N N3  . A1H7N B 2 .   ? -35.221 -18.600 0.438   1.00 32.37 ? 1101 A1H7N A N3  1 
HETATM 2209 C C17 . A1H7N B 2 .   ? -35.932 -19.642 0.891   1.00 32.64 ? 1101 A1H7N A C17 1 
HETATM 2210 N N2  . A1H7N B 2 .   ? -36.749 -17.140 1.586   1.00 31.88 ? 1101 A1H7N A N2  1 
HETATM 2211 I I   . IOD   C 3 .   ? -28.907 -6.337  2.706   0.50 51.98 ? 1102 IOD   A I   1 
HETATM 2212 I I   . IOD   D 3 .   ? -33.719 1.205   -0.023  0.50 32.36 ? 1103 IOD   A I   1 
HETATM 2213 I I   . IOD   E 3 .   ? -44.418 -15.880 17.225  0.50 79.70 ? 1104 IOD   A I   1 
HETATM 2214 I I   . IOD   F 3 .   ? -13.261 -15.525 18.856  1.00 55.72 ? 1105 IOD   A I   1 
HETATM 2215 I I   . IOD   G 3 .   ? -32.830 -33.440 16.141  0.20 40.47 ? 1106 IOD   A I   1 
HETATM 2216 I I   . IOD   H 3 .   ? -45.919 -11.886 8.828   0.20 23.50 ? 1107 IOD   A I   1 
HETATM 2217 I I   . IOD   I 3 .   ? -16.617 -19.964 7.815   1.00 51.81 ? 1108 IOD   A I   1 
HETATM 2218 I I   . IOD   J 3 .   ? -28.825 -5.395  -12.169 0.20 28.08 ? 1109 IOD   A I   1 
HETATM 2219 I I   . IOD   K 3 .   ? -16.335 -15.003 9.509   0.50 55.66 ? 1110 IOD   A I   1 
HETATM 2220 I I   . IOD   L 3 .   ? -35.066 -30.252 5.898   0.50 52.51 ? 1111 IOD   A I   1 
HETATM 2221 I I   . IOD   M 3 .   ? -32.172 -23.470 28.445  0.50 79.21 ? 1112 IOD   A I   1 
HETATM 2222 I I   . IOD   N 3 .   ? -27.074 -8.939  0.259   1.00 65.38 ? 1113 IOD   A I   1 
HETATM 2223 I I   . IOD   O 3 .   ? -25.330 -15.946 -2.218  0.50 54.48 ? 1114 IOD   A I   1 
HETATM 2224 I I   . IOD   P 3 .   ? -39.287 -1.335  0.221   0.50 86.31 ? 1115 IOD   A I   1 
HETATM 2225 I I   . IOD   Q 3 .   ? -39.290 -1.096  -15.110 1.00 93.02 ? 1116 IOD   A I   1 
HETATM 2226 O O   . HOH   R 4 .   ? -32.636 -30.378 26.876  1.00 24.61 ? 1201 HOH   A O   1 
HETATM 2227 O O   . HOH   R 4 .   ? -21.293 -26.188 -8.664  1.00 10.93 ? 1202 HOH   A O   1 
HETATM 2228 O O   . HOH   R 4 .   ? -30.679 -7.327  -13.898 1.00 16.46 ? 1203 HOH   A O   1 
HETATM 2229 O O   . HOH   R 4 .   ? -27.104 -8.922  -13.779 1.00 37.44 ? 1204 HOH   A O   1 
HETATM 2230 O O   . HOH   R 4 .   ? -34.293 -26.293 12.831  1.00 5.18  ? 1205 HOH   A O   1 
HETATM 2231 O O   . HOH   R 4 .   ? -15.832 -23.777 26.754  1.00 12.56 ? 1206 HOH   A O   1 
HETATM 2232 O O   . HOH   R 4 .   ? -31.499 -17.344 -16.669 1.00 13.53 ? 1207 HOH   A O   1 
HETATM 2233 O O   . HOH   R 4 .   ? -20.659 -2.948  28.700  1.00 22.96 ? 1208 HOH   A O   1 
HETATM 2234 O O   . HOH   R 4 .   ? -7.253  -17.351 8.780   1.00 27.31 ? 1209 HOH   A O   1 
HETATM 2235 O O   . HOH   R 4 .   ? -41.626 -12.106 4.172   1.00 4.54  ? 1210 HOH   A O   1 
HETATM 2236 O O   . HOH   R 4 .   ? -30.799 -1.050  35.552  1.00 16.78 ? 1211 HOH   A O   1 
HETATM 2237 O O   . HOH   R 4 .   ? -9.465  -16.333 18.420  1.00 14.33 ? 1212 HOH   A O   1 
HETATM 2238 O O   . HOH   R 4 .   ? -33.359 -8.334  -15.558 1.00 3.00  ? 1213 HOH   A O   1 
HETATM 2239 O O   . HOH   R 4 .   ? -38.978 -33.637 -11.092 1.00 27.45 ? 1214 HOH   A O   1 
HETATM 2240 O O   . HOH   R 4 .   ? -32.887 1.815   31.980  1.00 23.33 ? 1215 HOH   A O   1 
HETATM 2241 O O   . HOH   R 4 .   ? -28.595 -24.154 -12.209 1.00 29.00 ? 1216 HOH   A O   1 
HETATM 2242 O O   . HOH   R 4 .   ? -12.189 -19.222 20.054  1.00 9.53  ? 1217 HOH   A O   1 
HETATM 2243 O O   . HOH   R 4 .   ? -20.991 -12.460 35.249  1.00 11.44 ? 1218 HOH   A O   1 
HETATM 2244 O O   . HOH   R 4 .   ? -39.451 -26.547 -14.009 1.00 10.74 ? 1219 HOH   A O   1 
HETATM 2245 O O   . HOH   R 4 .   ? -23.568 -25.116 3.151   1.00 32.61 ? 1220 HOH   A O   1 
HETATM 2246 O O   . HOH   R 4 .   ? -14.766 -42.132 10.804  1.00 11.51 ? 1221 HOH   A O   1 
HETATM 2247 O O   . HOH   R 4 .   ? -18.259 -6.867  22.480  1.00 3.00  ? 1222 HOH   A O   1 
HETATM 2248 O O   . HOH   R 4 .   ? -17.692 -43.050 12.324  1.00 14.75 ? 1223 HOH   A O   1 
HETATM 2249 O O   . HOH   R 4 .   ? -30.830 -3.703  37.016  1.00 20.57 ? 1224 HOH   A O   1 
HETATM 2250 O O   . HOH   R 4 .   ? -48.401 -26.033 -4.049  1.00 3.00  ? 1225 HOH   A O   1 
HETATM 2251 O O   . HOH   R 4 .   ? -20.164 -9.967  5.939   1.00 18.47 ? 1226 HOH   A O   1 
HETATM 2252 O O   . HOH   R 4 .   ? -18.496 -16.650 5.043   1.00 16.74 ? 1227 HOH   A O   1 
HETATM 2253 O O   . HOH   R 4 .   ? -50.238 -30.830 -1.516  1.00 7.22  ? 1228 HOH   A O   1 
# 
