data_9ESW
# 
_entry.id   9ESW 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9ESW         pdb_00009esw 10.2210/pdb9esw/pdb 
WWPDB D_1292137164 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-09 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9ESW 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-26 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 jane.endicott@newcastle.ac.uk Jane    Endicott A.   'principal investigator/group leader' 0000-0003-4868-0116 
4 martin.noble@newcastle.ac.uk  Martin  Noble    E.M. 'principal investigator/group leader' 0000-0002-3595-9807 
5 mike.waring@newcastle.ac.uk   Michael Waring   J.   'principal investigator/group leader' 0000-0002-9110-8783 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hope, I.'       1 0000-0002-8002-5026 
'Martin, M.P.'   2 0000-0003-4810-3351 
'Waring, M.J.'   3 0000-0002-9110-8783 
'Noble, M.E.M.'  4 0000-0002-3595-9807 
'Endicott, J.A.' 5 0000-0003-4868-0116 
'Tatum, N.J.'    6 0000-0003-3878-9265 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hope, I.'       1 0000-0002-8002-5026 
primary 'Martin, M.P.'   2 0000-0003-4810-3351 
primary 'Waring, M.J.'   3 0000-0002-9110-8783 
primary 'Noble, M.E.M.'  4 0000-0002-3595-9807 
primary 'Endicott, J.A.' 5 0000-0003-4868-0116 
primary 'Tatum, N.J.'    6 0000-0003-3878-9265 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Cyclin-dependent kinase 2'        34354.770 2   2.7.11.22 ? ? ? 
2 polymer     man Cyclin-A2                          30817.473 2   ?         ? ? ? 
3 non-polymer syn '(4-bromanylpyridin-2-yl)methanol' 188.022   12  ?         ? ? ? 
4 water       nat water                              18.015    308 ?         ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'Cell division protein kinase 2,p33 protein kinase' 
2 Cyclin-A                                            
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no yes 
;GPGSMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKL
YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV
RTY(TPO)HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS
MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
;
;GPGSMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKL
YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV
RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY
KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
;
A,C ? 
2 'polypeptide(L)' no no  
;GVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLR
GKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVE
SLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIR
EKYKNSKYHGVSLLNPPETLNVHHHHHH
;
;GVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLR
GKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVE
SLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIR
EKYKNSKYHGVSLLNPPETLNVHHHHHH
;
B,D ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '(4-bromanylpyridin-2-yl)methanol' IJF 
4 water                              HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   SER n 
1 5   MET n 
1 6   GLU n 
1 7   ASN n 
1 8   PHE n 
1 9   GLN n 
1 10  LYS n 
1 11  VAL n 
1 12  GLU n 
1 13  LYS n 
1 14  ILE n 
1 15  GLY n 
1 16  GLU n 
1 17  GLY n 
1 18  THR n 
1 19  TYR n 
1 20  GLY n 
1 21  VAL n 
1 22  VAL n 
1 23  TYR n 
1 24  LYS n 
1 25  ALA n 
1 26  ARG n 
1 27  ASN n 
1 28  LYS n 
1 29  LEU n 
1 30  THR n 
1 31  GLY n 
1 32  GLU n 
1 33  VAL n 
1 34  VAL n 
1 35  ALA n 
1 36  LEU n 
1 37  LYS n 
1 38  LYS n 
1 39  ILE n 
1 40  ARG n 
1 41  LEU n 
1 42  ASP n 
1 43  THR n 
1 44  GLU n 
1 45  THR n 
1 46  GLU n 
1 47  GLY n 
1 48  VAL n 
1 49  PRO n 
1 50  SER n 
1 51  THR n 
1 52  ALA n 
1 53  ILE n 
1 54  ARG n 
1 55  GLU n 
1 56  ILE n 
1 57  SER n 
1 58  LEU n 
1 59  LEU n 
1 60  LYS n 
1 61  GLU n 
1 62  LEU n 
1 63  ASN n 
1 64  HIS n 
1 65  PRO n 
1 66  ASN n 
1 67  ILE n 
1 68  VAL n 
1 69  LYS n 
1 70  LEU n 
1 71  LEU n 
1 72  ASP n 
1 73  VAL n 
1 74  ILE n 
1 75  HIS n 
1 76  THR n 
1 77  GLU n 
1 78  ASN n 
1 79  LYS n 
1 80  LEU n 
1 81  TYR n 
1 82  LEU n 
1 83  VAL n 
1 84  PHE n 
1 85  GLU n 
1 86  PHE n 
1 87  LEU n 
1 88  HIS n 
1 89  GLN n 
1 90  ASP n 
1 91  LEU n 
1 92  LYS n 
1 93  LYS n 
1 94  PHE n 
1 95  MET n 
1 96  ASP n 
1 97  ALA n 
1 98  SER n 
1 99  ALA n 
1 100 LEU n 
1 101 THR n 
1 102 GLY n 
1 103 ILE n 
1 104 PRO n 
1 105 LEU n 
1 106 PRO n 
1 107 LEU n 
1 108 ILE n 
1 109 LYS n 
1 110 SER n 
1 111 TYR n 
1 112 LEU n 
1 113 PHE n 
1 114 GLN n 
1 115 LEU n 
1 116 LEU n 
1 117 GLN n 
1 118 GLY n 
1 119 LEU n 
1 120 ALA n 
1 121 PHE n 
1 122 CYS n 
1 123 HIS n 
1 124 SER n 
1 125 HIS n 
1 126 ARG n 
1 127 VAL n 
1 128 LEU n 
1 129 HIS n 
1 130 ARG n 
1 131 ASP n 
1 132 LEU n 
1 133 LYS n 
1 134 PRO n 
1 135 GLN n 
1 136 ASN n 
1 137 LEU n 
1 138 LEU n 
1 139 ILE n 
1 140 ASN n 
1 141 THR n 
1 142 GLU n 
1 143 GLY n 
1 144 ALA n 
1 145 ILE n 
1 146 LYS n 
1 147 LEU n 
1 148 ALA n 
1 149 ASP n 
1 150 PHE n 
1 151 GLY n 
1 152 LEU n 
1 153 ALA n 
1 154 ARG n 
1 155 ALA n 
1 156 PHE n 
1 157 GLY n 
1 158 VAL n 
1 159 PRO n 
1 160 VAL n 
1 161 ARG n 
1 162 THR n 
1 163 TYR n 
1 164 TPO n 
1 165 HIS n 
1 166 GLU n 
1 167 VAL n 
1 168 VAL n 
1 169 THR n 
1 170 LEU n 
1 171 TRP n 
1 172 TYR n 
1 173 ARG n 
1 174 ALA n 
1 175 PRO n 
1 176 GLU n 
1 177 ILE n 
1 178 LEU n 
1 179 LEU n 
1 180 GLY n 
1 181 CYS n 
1 182 LYS n 
1 183 TYR n 
1 184 TYR n 
1 185 SER n 
1 186 THR n 
1 187 ALA n 
1 188 VAL n 
1 189 ASP n 
1 190 ILE n 
1 191 TRP n 
1 192 SER n 
1 193 LEU n 
1 194 GLY n 
1 195 CYS n 
1 196 ILE n 
1 197 PHE n 
1 198 ALA n 
1 199 GLU n 
1 200 MET n 
1 201 VAL n 
1 202 THR n 
1 203 ARG n 
1 204 ARG n 
1 205 ALA n 
1 206 LEU n 
1 207 PHE n 
1 208 PRO n 
1 209 GLY n 
1 210 ASP n 
1 211 SER n 
1 212 GLU n 
1 213 ILE n 
1 214 ASP n 
1 215 GLN n 
1 216 LEU n 
1 217 PHE n 
1 218 ARG n 
1 219 ILE n 
1 220 PHE n 
1 221 ARG n 
1 222 THR n 
1 223 LEU n 
1 224 GLY n 
1 225 THR n 
1 226 PRO n 
1 227 ASP n 
1 228 GLU n 
1 229 VAL n 
1 230 VAL n 
1 231 TRP n 
1 232 PRO n 
1 233 GLY n 
1 234 VAL n 
1 235 THR n 
1 236 SER n 
1 237 MET n 
1 238 PRO n 
1 239 ASP n 
1 240 TYR n 
1 241 LYS n 
1 242 PRO n 
1 243 SER n 
1 244 PHE n 
1 245 PRO n 
1 246 LYS n 
1 247 TRP n 
1 248 ALA n 
1 249 ARG n 
1 250 GLN n 
1 251 ASP n 
1 252 PHE n 
1 253 SER n 
1 254 LYS n 
1 255 VAL n 
1 256 VAL n 
1 257 PRO n 
1 258 PRO n 
1 259 LEU n 
1 260 ASP n 
1 261 GLU n 
1 262 ASP n 
1 263 GLY n 
1 264 ARG n 
1 265 SER n 
1 266 LEU n 
1 267 LEU n 
1 268 SER n 
1 269 GLN n 
1 270 MET n 
1 271 LEU n 
1 272 HIS n 
1 273 TYR n 
1 274 ASP n 
1 275 PRO n 
1 276 ASN n 
1 277 LYS n 
1 278 ARG n 
1 279 ILE n 
1 280 SER n 
1 281 ALA n 
1 282 LYS n 
1 283 ALA n 
1 284 ALA n 
1 285 LEU n 
1 286 ALA n 
1 287 HIS n 
1 288 PRO n 
1 289 PHE n 
1 290 PHE n 
1 291 GLN n 
1 292 ASP n 
1 293 VAL n 
1 294 THR n 
1 295 LYS n 
1 296 PRO n 
1 297 VAL n 
1 298 PRO n 
1 299 HIS n 
1 300 LEU n 
1 301 ARG n 
1 302 LEU n 
2 1   GLY n 
2 2   VAL n 
2 3   ASN n 
2 4   GLU n 
2 5   VAL n 
2 6   PRO n 
2 7   ASP n 
2 8   TYR n 
2 9   HIS n 
2 10  GLU n 
2 11  ASP n 
2 12  ILE n 
2 13  HIS n 
2 14  THR n 
2 15  TYR n 
2 16  LEU n 
2 17  ARG n 
2 18  GLU n 
2 19  MET n 
2 20  GLU n 
2 21  VAL n 
2 22  LYS n 
2 23  CYS n 
2 24  LYS n 
2 25  PRO n 
2 26  LYS n 
2 27  VAL n 
2 28  GLY n 
2 29  TYR n 
2 30  MET n 
2 31  LYS n 
2 32  LYS n 
2 33  GLN n 
2 34  PRO n 
2 35  ASP n 
2 36  ILE n 
2 37  THR n 
2 38  ASN n 
2 39  SER n 
2 40  MET n 
2 41  ARG n 
2 42  ALA n 
2 43  ILE n 
2 44  LEU n 
2 45  VAL n 
2 46  ASP n 
2 47  TRP n 
2 48  LEU n 
2 49  VAL n 
2 50  GLU n 
2 51  VAL n 
2 52  GLY n 
2 53  GLU n 
2 54  GLU n 
2 55  TYR n 
2 56  LYS n 
2 57  LEU n 
2 58  GLN n 
2 59  ASN n 
2 60  GLU n 
2 61  THR n 
2 62  LEU n 
2 63  HIS n 
2 64  LEU n 
2 65  ALA n 
2 66  VAL n 
2 67  ASN n 
2 68  TYR n 
2 69  ILE n 
2 70  ASP n 
2 71  ARG n 
2 72  PHE n 
2 73  LEU n 
2 74  SER n 
2 75  SER n 
2 76  MET n 
2 77  SER n 
2 78  VAL n 
2 79  LEU n 
2 80  ARG n 
2 81  GLY n 
2 82  LYS n 
2 83  LEU n 
2 84  GLN n 
2 85  LEU n 
2 86  VAL n 
2 87  GLY n 
2 88  THR n 
2 89  ALA n 
2 90  ALA n 
2 91  MET n 
2 92  LEU n 
2 93  LEU n 
2 94  ALA n 
2 95  SER n 
2 96  LYS n 
2 97  PHE n 
2 98  GLU n 
2 99  GLU n 
2 100 ILE n 
2 101 TYR n 
2 102 PRO n 
2 103 PRO n 
2 104 GLU n 
2 105 VAL n 
2 106 ALA n 
2 107 GLU n 
2 108 PHE n 
2 109 VAL n 
2 110 TYR n 
2 111 ILE n 
2 112 THR n 
2 113 ASP n 
2 114 ASP n 
2 115 THR n 
2 116 TYR n 
2 117 THR n 
2 118 LYS n 
2 119 LYS n 
2 120 GLN n 
2 121 VAL n 
2 122 LEU n 
2 123 ARG n 
2 124 MET n 
2 125 GLU n 
2 126 HIS n 
2 127 LEU n 
2 128 VAL n 
2 129 LEU n 
2 130 LYS n 
2 131 VAL n 
2 132 LEU n 
2 133 ALA n 
2 134 PHE n 
2 135 ASP n 
2 136 LEU n 
2 137 ALA n 
2 138 ALA n 
2 139 PRO n 
2 140 THR n 
2 141 ILE n 
2 142 ASN n 
2 143 GLN n 
2 144 PHE n 
2 145 LEU n 
2 146 THR n 
2 147 GLN n 
2 148 TYR n 
2 149 PHE n 
2 150 LEU n 
2 151 HIS n 
2 152 GLN n 
2 153 GLN n 
2 154 PRO n 
2 155 ALA n 
2 156 ASN n 
2 157 CYS n 
2 158 LYS n 
2 159 VAL n 
2 160 GLU n 
2 161 SER n 
2 162 LEU n 
2 163 ALA n 
2 164 MET n 
2 165 PHE n 
2 166 LEU n 
2 167 GLY n 
2 168 GLU n 
2 169 LEU n 
2 170 SER n 
2 171 LEU n 
2 172 ILE n 
2 173 ASP n 
2 174 ALA n 
2 175 ASP n 
2 176 PRO n 
2 177 TYR n 
2 178 LEU n 
2 179 LYS n 
2 180 TYR n 
2 181 LEU n 
2 182 PRO n 
2 183 SER n 
2 184 VAL n 
2 185 ILE n 
2 186 ALA n 
2 187 ALA n 
2 188 ALA n 
2 189 ALA n 
2 190 PHE n 
2 191 HIS n 
2 192 LEU n 
2 193 ALA n 
2 194 LEU n 
2 195 TYR n 
2 196 THR n 
2 197 VAL n 
2 198 THR n 
2 199 GLY n 
2 200 GLN n 
2 201 SER n 
2 202 TRP n 
2 203 PRO n 
2 204 GLU n 
2 205 SER n 
2 206 LEU n 
2 207 VAL n 
2 208 GLN n 
2 209 LYS n 
2 210 THR n 
2 211 GLY n 
2 212 TYR n 
2 213 THR n 
2 214 LEU n 
2 215 GLU n 
2 216 THR n 
2 217 LEU n 
2 218 LYS n 
2 219 PRO n 
2 220 CYS n 
2 221 LEU n 
2 222 LEU n 
2 223 ASP n 
2 224 LEU n 
2 225 HIS n 
2 226 GLN n 
2 227 THR n 
2 228 TYR n 
2 229 LEU n 
2 230 ARG n 
2 231 ALA n 
2 232 PRO n 
2 233 GLN n 
2 234 HIS n 
2 235 ALA n 
2 236 GLN n 
2 237 GLN n 
2 238 SER n 
2 239 ILE n 
2 240 ARG n 
2 241 GLU n 
2 242 LYS n 
2 243 TYR n 
2 244 LYS n 
2 245 ASN n 
2 246 SER n 
2 247 LYS n 
2 248 TYR n 
2 249 HIS n 
2 250 GLY n 
2 251 VAL n 
2 252 SER n 
2 253 LEU n 
2 254 LEU n 
2 255 ASN n 
2 256 PRO n 
2 257 PRO n 
2 258 GLU n 
2 259 THR n 
2 260 LEU n 
2 261 ASN n 
2 262 VAL n 
2 263 HIS n 
2 264 HIS n 
2 265 HIS n 
2 266 HIS n 
2 267 HIS n 
2 268 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 302 human  ? 'CDK2, CDKN2' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? PGEX6P1 ? ? 
2 1 sample 'Biological sequence' 1 268 cattle ? CCNA2         ? ? ? ? ? ? 'Bos taurus'   9913 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? PET21d  ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                            ?                  'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                           ?                  'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                         ?                  'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                    ?                  'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                           ?                  'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                          ?                  'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                    ?                  'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                            ?                  'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                          ?                  'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                              ?                  'H2 O'           18.015  
IJF non-polymer         . '(4-bromanylpyridin-2-yl)methanol' ?                  'C6 H6 Br N O'   188.022 
ILE 'L-peptide linking' y ISOLEUCINE                         ?                  'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                            ?                  'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                             ?                  'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                         ?                  'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                      ?                  'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                            ?                  'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                             ?                  'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                          ?                  'C4 H9 N O3'     119.119 
TPO 'L-peptide linking' n PHOSPHOTHREONINE                   PHOSPHONOTHREONINE 'C4 H10 N O6 P'  199.099 
TRP 'L-peptide linking' y TRYPTOPHAN                         ?                  'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                           ?                  'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                             ?                  'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -3  -3  GLY GLY A . n 
A 1 2   PRO 2   -2  -2  PRO PRO A . n 
A 1 3   GLY 3   -1  -1  GLY GLY A . n 
A 1 4   SER 4   0   0   SER SER A . n 
A 1 5   MET 5   1   1   MET MET A . n 
A 1 6   GLU 6   2   2   GLU GLU A . n 
A 1 7   ASN 7   3   3   ASN ASN A . n 
A 1 8   PHE 8   4   4   PHE PHE A . n 
A 1 9   GLN 9   5   5   GLN GLN A . n 
A 1 10  LYS 10  6   6   LYS LYS A . n 
A 1 11  VAL 11  7   7   VAL VAL A . n 
A 1 12  GLU 12  8   8   GLU GLU A . n 
A 1 13  LYS 13  9   9   LYS LYS A . n 
A 1 14  ILE 14  10  10  ILE ILE A . n 
A 1 15  GLY 15  11  11  GLY GLY A . n 
A 1 16  GLU 16  12  12  GLU GLU A . n 
A 1 17  GLY 17  13  13  GLY GLY A . n 
A 1 18  THR 18  14  14  THR THR A . n 
A 1 19  TYR 19  15  15  TYR TYR A . n 
A 1 20  GLY 20  16  16  GLY GLY A . n 
A 1 21  VAL 21  17  17  VAL VAL A . n 
A 1 22  VAL 22  18  18  VAL VAL A . n 
A 1 23  TYR 23  19  19  TYR TYR A . n 
A 1 24  LYS 24  20  20  LYS LYS A . n 
A 1 25  ALA 25  21  21  ALA ALA A . n 
A 1 26  ARG 26  22  22  ARG ARG A . n 
A 1 27  ASN 27  23  23  ASN ASN A . n 
A 1 28  LYS 28  24  24  LYS LYS A . n 
A 1 29  LEU 29  25  25  LEU LEU A . n 
A 1 30  THR 30  26  26  THR THR A . n 
A 1 31  GLY 31  27  27  GLY GLY A . n 
A 1 32  GLU 32  28  28  GLU GLU A . n 
A 1 33  VAL 33  29  29  VAL VAL A . n 
A 1 34  VAL 34  30  30  VAL VAL A . n 
A 1 35  ALA 35  31  31  ALA ALA A . n 
A 1 36  LEU 36  32  32  LEU LEU A . n 
A 1 37  LYS 37  33  33  LYS LYS A . n 
A 1 38  LYS 38  34  34  LYS LYS A . n 
A 1 39  ILE 39  35  35  ILE ILE A . n 
A 1 40  ARG 40  36  36  ARG ARG A . n 
A 1 41  LEU 41  37  37  LEU LEU A . n 
A 1 42  ASP 42  38  38  ASP ASP A . n 
A 1 43  THR 43  39  39  THR THR A . n 
A 1 44  GLU 44  40  40  GLU GLU A . n 
A 1 45  THR 45  41  41  THR THR A . n 
A 1 46  GLU 46  42  42  GLU GLU A . n 
A 1 47  GLY 47  43  43  GLY GLY A . n 
A 1 48  VAL 48  44  44  VAL VAL A . n 
A 1 49  PRO 49  45  45  PRO PRO A . n 
A 1 50  SER 50  46  46  SER SER A . n 
A 1 51  THR 51  47  47  THR THR A . n 
A 1 52  ALA 52  48  48  ALA ALA A . n 
A 1 53  ILE 53  49  49  ILE ILE A . n 
A 1 54  ARG 54  50  50  ARG ARG A . n 
A 1 55  GLU 55  51  51  GLU GLU A . n 
A 1 56  ILE 56  52  52  ILE ILE A . n 
A 1 57  SER 57  53  53  SER SER A . n 
A 1 58  LEU 58  54  54  LEU LEU A . n 
A 1 59  LEU 59  55  55  LEU LEU A . n 
A 1 60  LYS 60  56  56  LYS LYS A . n 
A 1 61  GLU 61  57  57  GLU GLU A . n 
A 1 62  LEU 62  58  58  LEU LEU A . n 
A 1 63  ASN 63  59  59  ASN ASN A . n 
A 1 64  HIS 64  60  60  HIS HIS A . n 
A 1 65  PRO 65  61  61  PRO PRO A . n 
A 1 66  ASN 66  62  62  ASN ASN A . n 
A 1 67  ILE 67  63  63  ILE ILE A . n 
A 1 68  VAL 68  64  64  VAL VAL A . n 
A 1 69  LYS 69  65  65  LYS LYS A . n 
A 1 70  LEU 70  66  66  LEU LEU A . n 
A 1 71  LEU 71  67  67  LEU LEU A . n 
A 1 72  ASP 72  68  68  ASP ASP A . n 
A 1 73  VAL 73  69  69  VAL VAL A . n 
A 1 74  ILE 74  70  70  ILE ILE A . n 
A 1 75  HIS 75  71  71  HIS HIS A . n 
A 1 76  THR 76  72  72  THR THR A . n 
A 1 77  GLU 77  73  73  GLU GLU A . n 
A 1 78  ASN 78  74  74  ASN ASN A . n 
A 1 79  LYS 79  75  75  LYS LYS A . n 
A 1 80  LEU 80  76  76  LEU LEU A . n 
A 1 81  TYR 81  77  77  TYR TYR A . n 
A 1 82  LEU 82  78  78  LEU LEU A . n 
A 1 83  VAL 83  79  79  VAL VAL A . n 
A 1 84  PHE 84  80  80  PHE PHE A . n 
A 1 85  GLU 85  81  81  GLU GLU A . n 
A 1 86  PHE 86  82  82  PHE PHE A . n 
A 1 87  LEU 87  83  83  LEU LEU A . n 
A 1 88  HIS 88  84  84  HIS HIS A . n 
A 1 89  GLN 89  85  85  GLN GLN A . n 
A 1 90  ASP 90  86  86  ASP ASP A . n 
A 1 91  LEU 91  87  87  LEU LEU A . n 
A 1 92  LYS 92  88  88  LYS LYS A . n 
A 1 93  LYS 93  89  89  LYS LYS A . n 
A 1 94  PHE 94  90  90  PHE PHE A . n 
A 1 95  MET 95  91  91  MET MET A . n 
A 1 96  ASP 96  92  92  ASP ASP A . n 
A 1 97  ALA 97  93  93  ALA ALA A . n 
A 1 98  SER 98  94  94  SER SER A . n 
A 1 99  ALA 99  95  95  ALA ALA A . n 
A 1 100 LEU 100 96  96  LEU LEU A . n 
A 1 101 THR 101 97  97  THR THR A . n 
A 1 102 GLY 102 98  98  GLY GLY A . n 
A 1 103 ILE 103 99  99  ILE ILE A . n 
A 1 104 PRO 104 100 100 PRO PRO A . n 
A 1 105 LEU 105 101 101 LEU LEU A . n 
A 1 106 PRO 106 102 102 PRO PRO A . n 
A 1 107 LEU 107 103 103 LEU LEU A . n 
A 1 108 ILE 108 104 104 ILE ILE A . n 
A 1 109 LYS 109 105 105 LYS LYS A . n 
A 1 110 SER 110 106 106 SER SER A . n 
A 1 111 TYR 111 107 107 TYR TYR A . n 
A 1 112 LEU 112 108 108 LEU LEU A . n 
A 1 113 PHE 113 109 109 PHE PHE A . n 
A 1 114 GLN 114 110 110 GLN GLN A . n 
A 1 115 LEU 115 111 111 LEU LEU A . n 
A 1 116 LEU 116 112 112 LEU LEU A . n 
A 1 117 GLN 117 113 113 GLN GLN A . n 
A 1 118 GLY 118 114 114 GLY GLY A . n 
A 1 119 LEU 119 115 115 LEU LEU A . n 
A 1 120 ALA 120 116 116 ALA ALA A . n 
A 1 121 PHE 121 117 117 PHE PHE A . n 
A 1 122 CYS 122 118 118 CYS CYS A . n 
A 1 123 HIS 123 119 119 HIS HIS A . n 
A 1 124 SER 124 120 120 SER SER A . n 
A 1 125 HIS 125 121 121 HIS HIS A . n 
A 1 126 ARG 126 122 122 ARG ARG A . n 
A 1 127 VAL 127 123 123 VAL VAL A . n 
A 1 128 LEU 128 124 124 LEU LEU A . n 
A 1 129 HIS 129 125 125 HIS HIS A . n 
A 1 130 ARG 130 126 126 ARG ARG A . n 
A 1 131 ASP 131 127 127 ASP ASP A . n 
A 1 132 LEU 132 128 128 LEU LEU A . n 
A 1 133 LYS 133 129 129 LYS LYS A . n 
A 1 134 PRO 134 130 130 PRO PRO A . n 
A 1 135 GLN 135 131 131 GLN GLN A . n 
A 1 136 ASN 136 132 132 ASN ASN A . n 
A 1 137 LEU 137 133 133 LEU LEU A . n 
A 1 138 LEU 138 134 134 LEU LEU A . n 
A 1 139 ILE 139 135 135 ILE ILE A . n 
A 1 140 ASN 140 136 136 ASN ASN A . n 
A 1 141 THR 141 137 137 THR THR A . n 
A 1 142 GLU 142 138 138 GLU GLU A . n 
A 1 143 GLY 143 139 139 GLY GLY A . n 
A 1 144 ALA 144 140 140 ALA ALA A . n 
A 1 145 ILE 145 141 141 ILE ILE A . n 
A 1 146 LYS 146 142 142 LYS LYS A . n 
A 1 147 LEU 147 143 143 LEU LEU A . n 
A 1 148 ALA 148 144 144 ALA ALA A . n 
A 1 149 ASP 149 145 145 ASP ASP A . n 
A 1 150 PHE 150 146 146 PHE PHE A . n 
A 1 151 GLY 151 147 147 GLY GLY A . n 
A 1 152 LEU 152 148 148 LEU LEU A . n 
A 1 153 ALA 153 149 149 ALA ALA A . n 
A 1 154 ARG 154 150 150 ARG ARG A . n 
A 1 155 ALA 155 151 151 ALA ALA A . n 
A 1 156 PHE 156 152 152 PHE PHE A . n 
A 1 157 GLY 157 153 153 GLY GLY A . n 
A 1 158 VAL 158 154 154 VAL VAL A . n 
A 1 159 PRO 159 155 155 PRO PRO A . n 
A 1 160 VAL 160 156 156 VAL VAL A . n 
A 1 161 ARG 161 157 157 ARG ARG A . n 
A 1 162 THR 162 158 158 THR THR A . n 
A 1 163 TYR 163 159 159 TYR TYR A . n 
A 1 164 TPO 164 160 160 TPO TPO A . n 
A 1 165 HIS 165 161 161 HIS HIS A . n 
A 1 166 GLU 166 162 162 GLU GLU A . n 
A 1 167 VAL 167 163 163 VAL VAL A . n 
A 1 168 VAL 168 164 164 VAL VAL A . n 
A 1 169 THR 169 165 165 THR THR A . n 
A 1 170 LEU 170 166 166 LEU LEU A . n 
A 1 171 TRP 171 167 167 TRP TRP A . n 
A 1 172 TYR 172 168 168 TYR TYR A . n 
A 1 173 ARG 173 169 169 ARG ARG A . n 
A 1 174 ALA 174 170 170 ALA ALA A . n 
A 1 175 PRO 175 171 171 PRO PRO A . n 
A 1 176 GLU 176 172 172 GLU GLU A . n 
A 1 177 ILE 177 173 173 ILE ILE A . n 
A 1 178 LEU 178 174 174 LEU LEU A . n 
A 1 179 LEU 179 175 175 LEU LEU A . n 
A 1 180 GLY 180 176 176 GLY GLY A . n 
A 1 181 CYS 181 177 177 CYS CYS A . n 
A 1 182 LYS 182 178 178 LYS LYS A . n 
A 1 183 TYR 183 179 179 TYR TYR A . n 
A 1 184 TYR 184 180 180 TYR TYR A . n 
A 1 185 SER 185 181 181 SER SER A . n 
A 1 186 THR 186 182 182 THR THR A . n 
A 1 187 ALA 187 183 183 ALA ALA A . n 
A 1 188 VAL 188 184 184 VAL VAL A . n 
A 1 189 ASP 189 185 185 ASP ASP A . n 
A 1 190 ILE 190 186 186 ILE ILE A . n 
A 1 191 TRP 191 187 187 TRP TRP A . n 
A 1 192 SER 192 188 188 SER SER A . n 
A 1 193 LEU 193 189 189 LEU LEU A . n 
A 1 194 GLY 194 190 190 GLY GLY A . n 
A 1 195 CYS 195 191 191 CYS CYS A . n 
A 1 196 ILE 196 192 192 ILE ILE A . n 
A 1 197 PHE 197 193 193 PHE PHE A . n 
A 1 198 ALA 198 194 194 ALA ALA A . n 
A 1 199 GLU 199 195 195 GLU GLU A . n 
A 1 200 MET 200 196 196 MET MET A . n 
A 1 201 VAL 201 197 197 VAL VAL A . n 
A 1 202 THR 202 198 198 THR THR A . n 
A 1 203 ARG 203 199 199 ARG ARG A . n 
A 1 204 ARG 204 200 200 ARG ARG A . n 
A 1 205 ALA 205 201 201 ALA ALA A . n 
A 1 206 LEU 206 202 202 LEU LEU A . n 
A 1 207 PHE 207 203 203 PHE PHE A . n 
A 1 208 PRO 208 204 204 PRO PRO A . n 
A 1 209 GLY 209 205 205 GLY GLY A . n 
A 1 210 ASP 210 206 206 ASP ASP A . n 
A 1 211 SER 211 207 207 SER SER A . n 
A 1 212 GLU 212 208 208 GLU GLU A . n 
A 1 213 ILE 213 209 209 ILE ILE A . n 
A 1 214 ASP 214 210 210 ASP ASP A . n 
A 1 215 GLN 215 211 211 GLN GLN A . n 
A 1 216 LEU 216 212 212 LEU LEU A . n 
A 1 217 PHE 217 213 213 PHE PHE A . n 
A 1 218 ARG 218 214 214 ARG ARG A . n 
A 1 219 ILE 219 215 215 ILE ILE A . n 
A 1 220 PHE 220 216 216 PHE PHE A . n 
A 1 221 ARG 221 217 217 ARG ARG A . n 
A 1 222 THR 222 218 218 THR THR A . n 
A 1 223 LEU 223 219 219 LEU LEU A . n 
A 1 224 GLY 224 220 220 GLY GLY A . n 
A 1 225 THR 225 221 221 THR THR A . n 
A 1 226 PRO 226 222 222 PRO PRO A . n 
A 1 227 ASP 227 223 223 ASP ASP A . n 
A 1 228 GLU 228 224 224 GLU GLU A . n 
A 1 229 VAL 229 225 225 VAL VAL A . n 
A 1 230 VAL 230 226 226 VAL VAL A . n 
A 1 231 TRP 231 227 227 TRP TRP A . n 
A 1 232 PRO 232 228 228 PRO PRO A . n 
A 1 233 GLY 233 229 229 GLY GLY A . n 
A 1 234 VAL 234 230 230 VAL VAL A . n 
A 1 235 THR 235 231 231 THR THR A . n 
A 1 236 SER 236 232 232 SER SER A . n 
A 1 237 MET 237 233 233 MET MET A . n 
A 1 238 PRO 238 234 234 PRO PRO A . n 
A 1 239 ASP 239 235 235 ASP ASP A . n 
A 1 240 TYR 240 236 236 TYR TYR A . n 
A 1 241 LYS 241 237 237 LYS LYS A . n 
A 1 242 PRO 242 238 238 PRO PRO A . n 
A 1 243 SER 243 239 239 SER SER A . n 
A 1 244 PHE 244 240 240 PHE PHE A . n 
A 1 245 PRO 245 241 241 PRO PRO A . n 
A 1 246 LYS 246 242 242 LYS LYS A . n 
A 1 247 TRP 247 243 243 TRP TRP A . n 
A 1 248 ALA 248 244 244 ALA ALA A . n 
A 1 249 ARG 249 245 245 ARG ARG A . n 
A 1 250 GLN 250 246 246 GLN GLN A . n 
A 1 251 ASP 251 247 247 ASP ASP A . n 
A 1 252 PHE 252 248 248 PHE PHE A . n 
A 1 253 SER 253 249 249 SER SER A . n 
A 1 254 LYS 254 250 250 LYS LYS A . n 
A 1 255 VAL 255 251 251 VAL VAL A . n 
A 1 256 VAL 256 252 252 VAL VAL A . n 
A 1 257 PRO 257 253 253 PRO PRO A . n 
A 1 258 PRO 258 254 254 PRO PRO A . n 
A 1 259 LEU 259 255 255 LEU LEU A . n 
A 1 260 ASP 260 256 256 ASP ASP A . n 
A 1 261 GLU 261 257 257 GLU GLU A . n 
A 1 262 ASP 262 258 258 ASP ASP A . n 
A 1 263 GLY 263 259 259 GLY GLY A . n 
A 1 264 ARG 264 260 260 ARG ARG A . n 
A 1 265 SER 265 261 261 SER SER A . n 
A 1 266 LEU 266 262 262 LEU LEU A . n 
A 1 267 LEU 267 263 263 LEU LEU A . n 
A 1 268 SER 268 264 264 SER SER A . n 
A 1 269 GLN 269 265 265 GLN GLN A . n 
A 1 270 MET 270 266 266 MET MET A . n 
A 1 271 LEU 271 267 267 LEU LEU A . n 
A 1 272 HIS 272 268 268 HIS HIS A . n 
A 1 273 TYR 273 269 269 TYR TYR A . n 
A 1 274 ASP 274 270 270 ASP ASP A . n 
A 1 275 PRO 275 271 271 PRO PRO A . n 
A 1 276 ASN 276 272 272 ASN ASN A . n 
A 1 277 LYS 277 273 273 LYS LYS A . n 
A 1 278 ARG 278 274 274 ARG ARG A . n 
A 1 279 ILE 279 275 275 ILE ILE A . n 
A 1 280 SER 280 276 276 SER SER A . n 
A 1 281 ALA 281 277 277 ALA ALA A . n 
A 1 282 LYS 282 278 278 LYS LYS A . n 
A 1 283 ALA 283 279 279 ALA ALA A . n 
A 1 284 ALA 284 280 280 ALA ALA A . n 
A 1 285 LEU 285 281 281 LEU LEU A . n 
A 1 286 ALA 286 282 282 ALA ALA A . n 
A 1 287 HIS 287 283 283 HIS HIS A . n 
A 1 288 PRO 288 284 284 PRO PRO A . n 
A 1 289 PHE 289 285 285 PHE PHE A . n 
A 1 290 PHE 290 286 286 PHE PHE A . n 
A 1 291 GLN 291 287 287 GLN GLN A . n 
A 1 292 ASP 292 288 288 ASP ASP A . n 
A 1 293 VAL 293 289 289 VAL VAL A . n 
A 1 294 THR 294 290 290 THR THR A . n 
A 1 295 LYS 295 291 291 LYS LYS A . n 
A 1 296 PRO 296 292 292 PRO PRO A . n 
A 1 297 VAL 297 293 293 VAL VAL A . n 
A 1 298 PRO 298 294 294 PRO PRO A . n 
A 1 299 HIS 299 295 ?   ?   ?   A . n 
A 1 300 LEU 300 296 ?   ?   ?   A . n 
A 1 301 ARG 301 297 ?   ?   ?   A . n 
A 1 302 LEU 302 298 ?   ?   ?   A . n 
B 2 1   GLY 1   171 171 GLY GLY B . n 
B 2 2   VAL 2   172 172 VAL VAL B . n 
B 2 3   ASN 3   173 173 ASN ASN B . n 
B 2 4   GLU 4   174 174 GLU GLU B . n 
B 2 5   VAL 5   175 175 VAL VAL B . n 
B 2 6   PRO 6   176 176 PRO PRO B . n 
B 2 7   ASP 7   177 177 ASP ASP B . n 
B 2 8   TYR 8   178 178 TYR TYR B . n 
B 2 9   HIS 9   179 179 HIS HIS B . n 
B 2 10  GLU 10  180 180 GLU GLU B . n 
B 2 11  ASP 11  181 181 ASP ASP B . n 
B 2 12  ILE 12  182 182 ILE ILE B . n 
B 2 13  HIS 13  183 183 HIS HIS B . n 
B 2 14  THR 14  184 184 THR THR B . n 
B 2 15  TYR 15  185 185 TYR TYR B . n 
B 2 16  LEU 16  186 186 LEU LEU B . n 
B 2 17  ARG 17  187 187 ARG ARG B . n 
B 2 18  GLU 18  188 188 GLU GLU B . n 
B 2 19  MET 19  189 189 MET MET B . n 
B 2 20  GLU 20  190 190 GLU GLU B . n 
B 2 21  VAL 21  191 191 VAL VAL B . n 
B 2 22  LYS 22  192 192 LYS LYS B . n 
B 2 23  CYS 23  193 193 CYS CYS B . n 
B 2 24  LYS 24  194 194 LYS LYS B . n 
B 2 25  PRO 25  195 195 PRO PRO B . n 
B 2 26  LYS 26  196 196 LYS LYS B . n 
B 2 27  VAL 27  197 197 VAL VAL B . n 
B 2 28  GLY 28  198 198 GLY GLY B . n 
B 2 29  TYR 29  199 199 TYR TYR B . n 
B 2 30  MET 30  200 200 MET MET B . n 
B 2 31  LYS 31  201 201 LYS LYS B . n 
B 2 32  LYS 32  202 202 LYS LYS B . n 
B 2 33  GLN 33  203 203 GLN GLN B . n 
B 2 34  PRO 34  204 204 PRO PRO B . n 
B 2 35  ASP 35  205 205 ASP ASP B . n 
B 2 36  ILE 36  206 206 ILE ILE B . n 
B 2 37  THR 37  207 207 THR THR B . n 
B 2 38  ASN 38  208 208 ASN ASN B . n 
B 2 39  SER 39  209 209 SER SER B . n 
B 2 40  MET 40  210 210 MET MET B . n 
B 2 41  ARG 41  211 211 ARG ARG B . n 
B 2 42  ALA 42  212 212 ALA ALA B . n 
B 2 43  ILE 43  213 213 ILE ILE B . n 
B 2 44  LEU 44  214 214 LEU LEU B . n 
B 2 45  VAL 45  215 215 VAL VAL B . n 
B 2 46  ASP 46  216 216 ASP ASP B . n 
B 2 47  TRP 47  217 217 TRP TRP B . n 
B 2 48  LEU 48  218 218 LEU LEU B . n 
B 2 49  VAL 49  219 219 VAL VAL B . n 
B 2 50  GLU 50  220 220 GLU GLU B . n 
B 2 51  VAL 51  221 221 VAL VAL B . n 
B 2 52  GLY 52  222 222 GLY GLY B . n 
B 2 53  GLU 53  223 223 GLU GLU B . n 
B 2 54  GLU 54  224 224 GLU GLU B . n 
B 2 55  TYR 55  225 225 TYR TYR B . n 
B 2 56  LYS 56  226 226 LYS LYS B . n 
B 2 57  LEU 57  227 227 LEU LEU B . n 
B 2 58  GLN 58  228 228 GLN GLN B . n 
B 2 59  ASN 59  229 229 ASN ASN B . n 
B 2 60  GLU 60  230 230 GLU GLU B . n 
B 2 61  THR 61  231 231 THR THR B . n 
B 2 62  LEU 62  232 232 LEU LEU B . n 
B 2 63  HIS 63  233 233 HIS HIS B . n 
B 2 64  LEU 64  234 234 LEU LEU B . n 
B 2 65  ALA 65  235 235 ALA ALA B . n 
B 2 66  VAL 66  236 236 VAL VAL B . n 
B 2 67  ASN 67  237 237 ASN ASN B . n 
B 2 68  TYR 68  238 238 TYR TYR B . n 
B 2 69  ILE 69  239 239 ILE ILE B . n 
B 2 70  ASP 70  240 240 ASP ASP B . n 
B 2 71  ARG 71  241 241 ARG ARG B . n 
B 2 72  PHE 72  242 242 PHE PHE B . n 
B 2 73  LEU 73  243 243 LEU LEU B . n 
B 2 74  SER 74  244 244 SER SER B . n 
B 2 75  SER 75  245 245 SER SER B . n 
B 2 76  MET 76  246 246 MET MET B . n 
B 2 77  SER 77  247 247 SER SER B . n 
B 2 78  VAL 78  248 248 VAL VAL B . n 
B 2 79  LEU 79  249 249 LEU LEU B . n 
B 2 80  ARG 80  250 250 ARG ARG B . n 
B 2 81  GLY 81  251 251 GLY GLY B . n 
B 2 82  LYS 82  252 252 LYS LYS B . n 
B 2 83  LEU 83  253 253 LEU LEU B . n 
B 2 84  GLN 84  254 254 GLN GLN B . n 
B 2 85  LEU 85  255 255 LEU LEU B . n 
B 2 86  VAL 86  256 256 VAL VAL B . n 
B 2 87  GLY 87  257 257 GLY GLY B . n 
B 2 88  THR 88  258 258 THR THR B . n 
B 2 89  ALA 89  259 259 ALA ALA B . n 
B 2 90  ALA 90  260 260 ALA ALA B . n 
B 2 91  MET 91  261 261 MET MET B . n 
B 2 92  LEU 92  262 262 LEU LEU B . n 
B 2 93  LEU 93  263 263 LEU LEU B . n 
B 2 94  ALA 94  264 264 ALA ALA B . n 
B 2 95  SER 95  265 265 SER SER B . n 
B 2 96  LYS 96  266 266 LYS LYS B . n 
B 2 97  PHE 97  267 267 PHE PHE B . n 
B 2 98  GLU 98  268 268 GLU GLU B . n 
B 2 99  GLU 99  269 269 GLU GLU B . n 
B 2 100 ILE 100 270 270 ILE ILE B . n 
B 2 101 TYR 101 271 271 TYR TYR B . n 
B 2 102 PRO 102 272 272 PRO PRO B . n 
B 2 103 PRO 103 273 273 PRO PRO B . n 
B 2 104 GLU 104 274 274 GLU GLU B . n 
B 2 105 VAL 105 275 275 VAL VAL B . n 
B 2 106 ALA 106 276 276 ALA ALA B . n 
B 2 107 GLU 107 277 277 GLU GLU B . n 
B 2 108 PHE 108 278 278 PHE PHE B . n 
B 2 109 VAL 109 279 279 VAL VAL B . n 
B 2 110 TYR 110 280 280 TYR TYR B . n 
B 2 111 ILE 111 281 281 ILE ILE B . n 
B 2 112 THR 112 282 282 THR THR B . n 
B 2 113 ASP 113 283 283 ASP ASP B . n 
B 2 114 ASP 114 284 284 ASP ASP B . n 
B 2 115 THR 115 285 285 THR THR B . n 
B 2 116 TYR 116 286 286 TYR TYR B . n 
B 2 117 THR 117 287 287 THR THR B . n 
B 2 118 LYS 118 288 288 LYS LYS B . n 
B 2 119 LYS 119 289 289 LYS LYS B . n 
B 2 120 GLN 120 290 290 GLN GLN B . n 
B 2 121 VAL 121 291 291 VAL VAL B . n 
B 2 122 LEU 122 292 292 LEU LEU B . n 
B 2 123 ARG 123 293 293 ARG ARG B . n 
B 2 124 MET 124 294 294 MET MET B . n 
B 2 125 GLU 125 295 295 GLU GLU B . n 
B 2 126 HIS 126 296 296 HIS HIS B . n 
B 2 127 LEU 127 297 297 LEU LEU B . n 
B 2 128 VAL 128 298 298 VAL VAL B . n 
B 2 129 LEU 129 299 299 LEU LEU B . n 
B 2 130 LYS 130 300 300 LYS LYS B . n 
B 2 131 VAL 131 301 301 VAL VAL B . n 
B 2 132 LEU 132 302 302 LEU LEU B . n 
B 2 133 ALA 133 303 303 ALA ALA B . n 
B 2 134 PHE 134 304 304 PHE PHE B . n 
B 2 135 ASP 135 305 305 ASP ASP B . n 
B 2 136 LEU 136 306 306 LEU LEU B . n 
B 2 137 ALA 137 307 307 ALA ALA B . n 
B 2 138 ALA 138 308 308 ALA ALA B . n 
B 2 139 PRO 139 309 309 PRO PRO B . n 
B 2 140 THR 140 310 310 THR THR B . n 
B 2 141 ILE 141 311 311 ILE ILE B . n 
B 2 142 ASN 142 312 312 ASN ASN B . n 
B 2 143 GLN 143 313 313 GLN GLN B . n 
B 2 144 PHE 144 314 314 PHE PHE B . n 
B 2 145 LEU 145 315 315 LEU LEU B . n 
B 2 146 THR 146 316 316 THR THR B . n 
B 2 147 GLN 147 317 317 GLN GLN B . n 
B 2 148 TYR 148 318 318 TYR TYR B . n 
B 2 149 PHE 149 319 319 PHE PHE B . n 
B 2 150 LEU 150 320 320 LEU LEU B . n 
B 2 151 HIS 151 321 321 HIS HIS B . n 
B 2 152 GLN 152 322 322 GLN GLN B . n 
B 2 153 GLN 153 323 323 GLN GLN B . n 
B 2 154 PRO 154 324 324 PRO PRO B . n 
B 2 155 ALA 155 325 325 ALA ALA B . n 
B 2 156 ASN 156 326 326 ASN ASN B . n 
B 2 157 CYS 157 327 327 CYS CYS B . n 
B 2 158 LYS 158 328 328 LYS LYS B . n 
B 2 159 VAL 159 329 329 VAL VAL B . n 
B 2 160 GLU 160 330 330 GLU GLU B . n 
B 2 161 SER 161 331 331 SER SER B . n 
B 2 162 LEU 162 332 332 LEU LEU B . n 
B 2 163 ALA 163 333 333 ALA ALA B . n 
B 2 164 MET 164 334 334 MET MET B . n 
B 2 165 PHE 165 335 335 PHE PHE B . n 
B 2 166 LEU 166 336 336 LEU LEU B . n 
B 2 167 GLY 167 337 337 GLY GLY B . n 
B 2 168 GLU 168 338 338 GLU GLU B . n 
B 2 169 LEU 169 339 339 LEU LEU B . n 
B 2 170 SER 170 340 340 SER SER B . n 
B 2 171 LEU 171 341 341 LEU LEU B . n 
B 2 172 ILE 172 342 342 ILE ILE B . n 
B 2 173 ASP 173 343 343 ASP ASP B . n 
B 2 174 ALA 174 344 344 ALA ALA B . n 
B 2 175 ASP 175 345 345 ASP ASP B . n 
B 2 176 PRO 176 346 346 PRO PRO B . n 
B 2 177 TYR 177 347 347 TYR TYR B . n 
B 2 178 LEU 178 348 348 LEU LEU B . n 
B 2 179 LYS 179 349 349 LYS LYS B . n 
B 2 180 TYR 180 350 350 TYR TYR B . n 
B 2 181 LEU 181 351 351 LEU LEU B . n 
B 2 182 PRO 182 352 352 PRO PRO B . n 
B 2 183 SER 183 353 353 SER SER B . n 
B 2 184 VAL 184 354 354 VAL VAL B . n 
B 2 185 ILE 185 355 355 ILE ILE B . n 
B 2 186 ALA 186 356 356 ALA ALA B . n 
B 2 187 ALA 187 357 357 ALA ALA B . n 
B 2 188 ALA 188 358 358 ALA ALA B . n 
B 2 189 ALA 189 359 359 ALA ALA B . n 
B 2 190 PHE 190 360 360 PHE PHE B . n 
B 2 191 HIS 191 361 361 HIS HIS B . n 
B 2 192 LEU 192 362 362 LEU LEU B . n 
B 2 193 ALA 193 363 363 ALA ALA B . n 
B 2 194 LEU 194 364 364 LEU LEU B . n 
B 2 195 TYR 195 365 365 TYR TYR B . n 
B 2 196 THR 196 366 366 THR THR B . n 
B 2 197 VAL 197 367 367 VAL VAL B . n 
B 2 198 THR 198 368 368 THR THR B . n 
B 2 199 GLY 199 369 369 GLY GLY B . n 
B 2 200 GLN 200 370 370 GLN GLN B . n 
B 2 201 SER 201 371 371 SER SER B . n 
B 2 202 TRP 202 372 372 TRP TRP B . n 
B 2 203 PRO 203 373 373 PRO PRO B . n 
B 2 204 GLU 204 374 374 GLU GLU B . n 
B 2 205 SER 205 375 375 SER SER B . n 
B 2 206 LEU 206 376 376 LEU LEU B . n 
B 2 207 VAL 207 377 377 VAL VAL B . n 
B 2 208 GLN 208 378 378 GLN GLN B . n 
B 2 209 LYS 209 379 379 LYS LYS B . n 
B 2 210 THR 210 380 380 THR THR B . n 
B 2 211 GLY 211 381 381 GLY GLY B . n 
B 2 212 TYR 212 382 382 TYR TYR B . n 
B 2 213 THR 213 383 383 THR THR B . n 
B 2 214 LEU 214 384 384 LEU LEU B . n 
B 2 215 GLU 215 385 385 GLU GLU B . n 
B 2 216 THR 216 386 386 THR THR B . n 
B 2 217 LEU 217 387 387 LEU LEU B . n 
B 2 218 LYS 218 388 388 LYS LYS B . n 
B 2 219 PRO 219 389 389 PRO PRO B . n 
B 2 220 CYS 220 390 390 CYS CYS B . n 
B 2 221 LEU 221 391 391 LEU LEU B . n 
B 2 222 LEU 222 392 392 LEU LEU B . n 
B 2 223 ASP 223 393 393 ASP ASP B . n 
B 2 224 LEU 224 394 394 LEU LEU B . n 
B 2 225 HIS 225 395 395 HIS HIS B . n 
B 2 226 GLN 226 396 396 GLN GLN B . n 
B 2 227 THR 227 397 397 THR THR B . n 
B 2 228 TYR 228 398 398 TYR TYR B . n 
B 2 229 LEU 229 399 399 LEU LEU B . n 
B 2 230 ARG 230 400 400 ARG ARG B . n 
B 2 231 ALA 231 401 401 ALA ALA B . n 
B 2 232 PRO 232 402 402 PRO PRO B . n 
B 2 233 GLN 233 403 403 GLN GLN B . n 
B 2 234 HIS 234 404 404 HIS HIS B . n 
B 2 235 ALA 235 405 405 ALA ALA B . n 
B 2 236 GLN 236 406 406 GLN GLN B . n 
B 2 237 GLN 237 407 407 GLN GLN B . n 
B 2 238 SER 238 408 408 SER SER B . n 
B 2 239 ILE 239 409 409 ILE ILE B . n 
B 2 240 ARG 240 410 410 ARG ARG B . n 
B 2 241 GLU 241 411 411 GLU GLU B . n 
B 2 242 LYS 242 412 412 LYS LYS B . n 
B 2 243 TYR 243 413 413 TYR TYR B . n 
B 2 244 LYS 244 414 414 LYS LYS B . n 
B 2 245 ASN 245 415 415 ASN ASN B . n 
B 2 246 SER 246 416 416 SER SER B . n 
B 2 247 LYS 247 417 417 LYS LYS B . n 
B 2 248 TYR 248 418 418 TYR TYR B . n 
B 2 249 HIS 249 419 419 HIS HIS B . n 
B 2 250 GLY 250 420 420 GLY GLY B . n 
B 2 251 VAL 251 421 421 VAL VAL B . n 
B 2 252 SER 252 422 422 SER SER B . n 
B 2 253 LEU 253 423 423 LEU LEU B . n 
B 2 254 LEU 254 424 424 LEU LEU B . n 
B 2 255 ASN 255 425 425 ASN ASN B . n 
B 2 256 PRO 256 426 426 PRO PRO B . n 
B 2 257 PRO 257 427 427 PRO PRO B . n 
B 2 258 GLU 258 428 428 GLU GLU B . n 
B 2 259 THR 259 429 429 THR THR B . n 
B 2 260 LEU 260 430 430 LEU LEU B . n 
B 2 261 ASN 261 431 431 ASN ASN B . n 
B 2 262 VAL 262 432 432 VAL VAL B . n 
B 2 263 HIS 263 433 ?   ?   ?   B . n 
B 2 264 HIS 264 434 ?   ?   ?   B . n 
B 2 265 HIS 265 435 ?   ?   ?   B . n 
B 2 266 HIS 266 436 ?   ?   ?   B . n 
B 2 267 HIS 267 437 ?   ?   ?   B . n 
B 2 268 HIS 268 438 ?   ?   ?   B . n 
C 1 1   GLY 1   -3  ?   ?   ?   C . n 
C 1 2   PRO 2   -2  ?   ?   ?   C . n 
C 1 3   GLY 3   -1  ?   ?   ?   C . n 
C 1 4   SER 4   0   0   SER SER C . n 
C 1 5   MET 5   1   1   MET MET C . n 
C 1 6   GLU 6   2   2   GLU GLU C . n 
C 1 7   ASN 7   3   3   ASN ASN C . n 
C 1 8   PHE 8   4   4   PHE PHE C . n 
C 1 9   GLN 9   5   5   GLN GLN C . n 
C 1 10  LYS 10  6   6   LYS LYS C . n 
C 1 11  VAL 11  7   7   VAL VAL C . n 
C 1 12  GLU 12  8   8   GLU GLU C . n 
C 1 13  LYS 13  9   9   LYS LYS C . n 
C 1 14  ILE 14  10  10  ILE ILE C . n 
C 1 15  GLY 15  11  11  GLY GLY C . n 
C 1 16  GLU 16  12  12  GLU GLU C . n 
C 1 17  GLY 17  13  13  GLY GLY C . n 
C 1 18  THR 18  14  14  THR THR C . n 
C 1 19  TYR 19  15  15  TYR TYR C . n 
C 1 20  GLY 20  16  16  GLY GLY C . n 
C 1 21  VAL 21  17  17  VAL VAL C . n 
C 1 22  VAL 22  18  18  VAL VAL C . n 
C 1 23  TYR 23  19  19  TYR TYR C . n 
C 1 24  LYS 24  20  20  LYS LYS C . n 
C 1 25  ALA 25  21  21  ALA ALA C . n 
C 1 26  ARG 26  22  22  ARG ARG C . n 
C 1 27  ASN 27  23  23  ASN ASN C . n 
C 1 28  LYS 28  24  24  LYS LYS C . n 
C 1 29  LEU 29  25  25  LEU LEU C . n 
C 1 30  THR 30  26  26  THR THR C . n 
C 1 31  GLY 31  27  27  GLY GLY C . n 
C 1 32  GLU 32  28  28  GLU GLU C . n 
C 1 33  VAL 33  29  29  VAL VAL C . n 
C 1 34  VAL 34  30  30  VAL VAL C . n 
C 1 35  ALA 35  31  31  ALA ALA C . n 
C 1 36  LEU 36  32  32  LEU LEU C . n 
C 1 37  LYS 37  33  33  LYS LYS C . n 
C 1 38  LYS 38  34  34  LYS LYS C . n 
C 1 39  ILE 39  35  35  ILE ILE C . n 
C 1 40  ARG 40  36  36  ARG ARG C . n 
C 1 41  LEU 41  37  37  LEU LEU C . n 
C 1 42  ASP 42  38  38  ASP ASP C . n 
C 1 43  THR 43  39  39  THR THR C . n 
C 1 44  GLU 44  40  40  GLU GLU C . n 
C 1 45  THR 45  41  41  THR THR C . n 
C 1 46  GLU 46  42  42  GLU GLU C . n 
C 1 47  GLY 47  43  43  GLY GLY C . n 
C 1 48  VAL 48  44  44  VAL VAL C . n 
C 1 49  PRO 49  45  45  PRO PRO C . n 
C 1 50  SER 50  46  46  SER SER C . n 
C 1 51  THR 51  47  47  THR THR C . n 
C 1 52  ALA 52  48  48  ALA ALA C . n 
C 1 53  ILE 53  49  49  ILE ILE C . n 
C 1 54  ARG 54  50  50  ARG ARG C . n 
C 1 55  GLU 55  51  51  GLU GLU C . n 
C 1 56  ILE 56  52  52  ILE ILE C . n 
C 1 57  SER 57  53  53  SER SER C . n 
C 1 58  LEU 58  54  54  LEU LEU C . n 
C 1 59  LEU 59  55  55  LEU LEU C . n 
C 1 60  LYS 60  56  56  LYS LYS C . n 
C 1 61  GLU 61  57  57  GLU GLU C . n 
C 1 62  LEU 62  58  58  LEU LEU C . n 
C 1 63  ASN 63  59  59  ASN ASN C . n 
C 1 64  HIS 64  60  60  HIS HIS C . n 
C 1 65  PRO 65  61  61  PRO PRO C . n 
C 1 66  ASN 66  62  62  ASN ASN C . n 
C 1 67  ILE 67  63  63  ILE ILE C . n 
C 1 68  VAL 68  64  64  VAL VAL C . n 
C 1 69  LYS 69  65  65  LYS LYS C . n 
C 1 70  LEU 70  66  66  LEU LEU C . n 
C 1 71  LEU 71  67  67  LEU LEU C . n 
C 1 72  ASP 72  68  68  ASP ASP C . n 
C 1 73  VAL 73  69  69  VAL VAL C . n 
C 1 74  ILE 74  70  70  ILE ILE C . n 
C 1 75  HIS 75  71  71  HIS HIS C . n 
C 1 76  THR 76  72  72  THR THR C . n 
C 1 77  GLU 77  73  73  GLU GLU C . n 
C 1 78  ASN 78  74  74  ASN ASN C . n 
C 1 79  LYS 79  75  75  LYS LYS C . n 
C 1 80  LEU 80  76  76  LEU LEU C . n 
C 1 81  TYR 81  77  77  TYR TYR C . n 
C 1 82  LEU 82  78  78  LEU LEU C . n 
C 1 83  VAL 83  79  79  VAL VAL C . n 
C 1 84  PHE 84  80  80  PHE PHE C . n 
C 1 85  GLU 85  81  81  GLU GLU C . n 
C 1 86  PHE 86  82  82  PHE PHE C . n 
C 1 87  LEU 87  83  83  LEU LEU C . n 
C 1 88  HIS 88  84  84  HIS HIS C . n 
C 1 89  GLN 89  85  85  GLN GLN C . n 
C 1 90  ASP 90  86  86  ASP ASP C . n 
C 1 91  LEU 91  87  87  LEU LEU C . n 
C 1 92  LYS 92  88  88  LYS LYS C . n 
C 1 93  LYS 93  89  89  LYS LYS C . n 
C 1 94  PHE 94  90  90  PHE PHE C . n 
C 1 95  MET 95  91  91  MET MET C . n 
C 1 96  ASP 96  92  92  ASP ASP C . n 
C 1 97  ALA 97  93  93  ALA ALA C . n 
C 1 98  SER 98  94  94  SER SER C . n 
C 1 99  ALA 99  95  95  ALA ALA C . n 
C 1 100 LEU 100 96  96  LEU LEU C . n 
C 1 101 THR 101 97  97  THR THR C . n 
C 1 102 GLY 102 98  98  GLY GLY C . n 
C 1 103 ILE 103 99  99  ILE ILE C . n 
C 1 104 PRO 104 100 100 PRO PRO C . n 
C 1 105 LEU 105 101 101 LEU LEU C . n 
C 1 106 PRO 106 102 102 PRO PRO C . n 
C 1 107 LEU 107 103 103 LEU LEU C . n 
C 1 108 ILE 108 104 104 ILE ILE C . n 
C 1 109 LYS 109 105 105 LYS LYS C . n 
C 1 110 SER 110 106 106 SER SER C . n 
C 1 111 TYR 111 107 107 TYR TYR C . n 
C 1 112 LEU 112 108 108 LEU LEU C . n 
C 1 113 PHE 113 109 109 PHE PHE C . n 
C 1 114 GLN 114 110 110 GLN GLN C . n 
C 1 115 LEU 115 111 111 LEU LEU C . n 
C 1 116 LEU 116 112 112 LEU LEU C . n 
C 1 117 GLN 117 113 113 GLN GLN C . n 
C 1 118 GLY 118 114 114 GLY GLY C . n 
C 1 119 LEU 119 115 115 LEU LEU C . n 
C 1 120 ALA 120 116 116 ALA ALA C . n 
C 1 121 PHE 121 117 117 PHE PHE C . n 
C 1 122 CYS 122 118 118 CYS CYS C . n 
C 1 123 HIS 123 119 119 HIS HIS C . n 
C 1 124 SER 124 120 120 SER SER C . n 
C 1 125 HIS 125 121 121 HIS HIS C . n 
C 1 126 ARG 126 122 122 ARG ARG C . n 
C 1 127 VAL 127 123 123 VAL VAL C . n 
C 1 128 LEU 128 124 124 LEU LEU C . n 
C 1 129 HIS 129 125 125 HIS HIS C . n 
C 1 130 ARG 130 126 126 ARG ARG C . n 
C 1 131 ASP 131 127 127 ASP ASP C . n 
C 1 132 LEU 132 128 128 LEU LEU C . n 
C 1 133 LYS 133 129 129 LYS LYS C . n 
C 1 134 PRO 134 130 130 PRO PRO C . n 
C 1 135 GLN 135 131 131 GLN GLN C . n 
C 1 136 ASN 136 132 132 ASN ASN C . n 
C 1 137 LEU 137 133 133 LEU LEU C . n 
C 1 138 LEU 138 134 134 LEU LEU C . n 
C 1 139 ILE 139 135 135 ILE ILE C . n 
C 1 140 ASN 140 136 136 ASN ASN C . n 
C 1 141 THR 141 137 137 THR THR C . n 
C 1 142 GLU 142 138 138 GLU GLU C . n 
C 1 143 GLY 143 139 139 GLY GLY C . n 
C 1 144 ALA 144 140 140 ALA ALA C . n 
C 1 145 ILE 145 141 141 ILE ILE C . n 
C 1 146 LYS 146 142 142 LYS LYS C . n 
C 1 147 LEU 147 143 143 LEU LEU C . n 
C 1 148 ALA 148 144 144 ALA ALA C . n 
C 1 149 ASP 149 145 145 ASP ASP C . n 
C 1 150 PHE 150 146 146 PHE PHE C . n 
C 1 151 GLY 151 147 147 GLY GLY C . n 
C 1 152 LEU 152 148 148 LEU LEU C . n 
C 1 153 ALA 153 149 149 ALA ALA C . n 
C 1 154 ARG 154 150 150 ARG ARG C . n 
C 1 155 ALA 155 151 151 ALA ALA C . n 
C 1 156 PHE 156 152 152 PHE PHE C . n 
C 1 157 GLY 157 153 153 GLY GLY C . n 
C 1 158 VAL 158 154 154 VAL VAL C . n 
C 1 159 PRO 159 155 155 PRO PRO C . n 
C 1 160 VAL 160 156 156 VAL VAL C . n 
C 1 161 ARG 161 157 157 ARG ARG C . n 
C 1 162 THR 162 158 158 THR THR C . n 
C 1 163 TYR 163 159 159 TYR TYR C . n 
C 1 164 TPO 164 160 160 TPO TPO C . n 
C 1 165 HIS 165 161 161 HIS HIS C . n 
C 1 166 GLU 166 162 162 GLU GLU C . n 
C 1 167 VAL 167 163 163 VAL VAL C . n 
C 1 168 VAL 168 164 164 VAL VAL C . n 
C 1 169 THR 169 165 165 THR THR C . n 
C 1 170 LEU 170 166 166 LEU LEU C . n 
C 1 171 TRP 171 167 167 TRP TRP C . n 
C 1 172 TYR 172 168 168 TYR TYR C . n 
C 1 173 ARG 173 169 169 ARG ARG C . n 
C 1 174 ALA 174 170 170 ALA ALA C . n 
C 1 175 PRO 175 171 171 PRO PRO C . n 
C 1 176 GLU 176 172 172 GLU GLU C . n 
C 1 177 ILE 177 173 173 ILE ILE C . n 
C 1 178 LEU 178 174 174 LEU LEU C . n 
C 1 179 LEU 179 175 175 LEU LEU C . n 
C 1 180 GLY 180 176 176 GLY GLY C . n 
C 1 181 CYS 181 177 177 CYS CYS C . n 
C 1 182 LYS 182 178 178 LYS LYS C . n 
C 1 183 TYR 183 179 179 TYR TYR C . n 
C 1 184 TYR 184 180 180 TYR TYR C . n 
C 1 185 SER 185 181 181 SER SER C . n 
C 1 186 THR 186 182 182 THR THR C . n 
C 1 187 ALA 187 183 183 ALA ALA C . n 
C 1 188 VAL 188 184 184 VAL VAL C . n 
C 1 189 ASP 189 185 185 ASP ASP C . n 
C 1 190 ILE 190 186 186 ILE ILE C . n 
C 1 191 TRP 191 187 187 TRP TRP C . n 
C 1 192 SER 192 188 188 SER SER C . n 
C 1 193 LEU 193 189 189 LEU LEU C . n 
C 1 194 GLY 194 190 190 GLY GLY C . n 
C 1 195 CYS 195 191 191 CYS CYS C . n 
C 1 196 ILE 196 192 192 ILE ILE C . n 
C 1 197 PHE 197 193 193 PHE PHE C . n 
C 1 198 ALA 198 194 194 ALA ALA C . n 
C 1 199 GLU 199 195 195 GLU GLU C . n 
C 1 200 MET 200 196 196 MET MET C . n 
C 1 201 VAL 201 197 197 VAL VAL C . n 
C 1 202 THR 202 198 198 THR THR C . n 
C 1 203 ARG 203 199 199 ARG ARG C . n 
C 1 204 ARG 204 200 200 ARG ARG C . n 
C 1 205 ALA 205 201 201 ALA ALA C . n 
C 1 206 LEU 206 202 202 LEU LEU C . n 
C 1 207 PHE 207 203 203 PHE PHE C . n 
C 1 208 PRO 208 204 204 PRO PRO C . n 
C 1 209 GLY 209 205 205 GLY GLY C . n 
C 1 210 ASP 210 206 206 ASP ASP C . n 
C 1 211 SER 211 207 207 SER SER C . n 
C 1 212 GLU 212 208 208 GLU GLU C . n 
C 1 213 ILE 213 209 209 ILE ILE C . n 
C 1 214 ASP 214 210 210 ASP ASP C . n 
C 1 215 GLN 215 211 211 GLN GLN C . n 
C 1 216 LEU 216 212 212 LEU LEU C . n 
C 1 217 PHE 217 213 213 PHE PHE C . n 
C 1 218 ARG 218 214 214 ARG ARG C . n 
C 1 219 ILE 219 215 215 ILE ILE C . n 
C 1 220 PHE 220 216 216 PHE PHE C . n 
C 1 221 ARG 221 217 217 ARG ARG C . n 
C 1 222 THR 222 218 218 THR THR C . n 
C 1 223 LEU 223 219 219 LEU LEU C . n 
C 1 224 GLY 224 220 220 GLY GLY C . n 
C 1 225 THR 225 221 ?   ?   ?   C . n 
C 1 226 PRO 226 222 ?   ?   ?   C . n 
C 1 227 ASP 227 223 ?   ?   ?   C . n 
C 1 228 GLU 228 224 ?   ?   ?   C . n 
C 1 229 VAL 229 225 ?   ?   ?   C . n 
C 1 230 VAL 230 226 ?   ?   ?   C . n 
C 1 231 TRP 231 227 ?   ?   ?   C . n 
C 1 232 PRO 232 228 ?   ?   ?   C . n 
C 1 233 GLY 233 229 ?   ?   ?   C . n 
C 1 234 VAL 234 230 ?   ?   ?   C . n 
C 1 235 THR 235 231 ?   ?   ?   C . n 
C 1 236 SER 236 232 ?   ?   ?   C . n 
C 1 237 MET 237 233 ?   ?   ?   C . n 
C 1 238 PRO 238 234 ?   ?   ?   C . n 
C 1 239 ASP 239 235 ?   ?   ?   C . n 
C 1 240 TYR 240 236 ?   ?   ?   C . n 
C 1 241 LYS 241 237 ?   ?   ?   C . n 
C 1 242 PRO 242 238 ?   ?   ?   C . n 
C 1 243 SER 243 239 ?   ?   ?   C . n 
C 1 244 PHE 244 240 ?   ?   ?   C . n 
C 1 245 PRO 245 241 ?   ?   ?   C . n 
C 1 246 LYS 246 242 ?   ?   ?   C . n 
C 1 247 TRP 247 243 ?   ?   ?   C . n 
C 1 248 ALA 248 244 ?   ?   ?   C . n 
C 1 249 ARG 249 245 ?   ?   ?   C . n 
C 1 250 GLN 250 246 ?   ?   ?   C . n 
C 1 251 ASP 251 247 ?   ?   ?   C . n 
C 1 252 PHE 252 248 248 PHE PHE C . n 
C 1 253 SER 253 249 249 SER SER C . n 
C 1 254 LYS 254 250 250 LYS LYS C . n 
C 1 255 VAL 255 251 251 VAL VAL C . n 
C 1 256 VAL 256 252 252 VAL VAL C . n 
C 1 257 PRO 257 253 253 PRO PRO C . n 
C 1 258 PRO 258 254 254 PRO PRO C . n 
C 1 259 LEU 259 255 255 LEU LEU C . n 
C 1 260 ASP 260 256 256 ASP ASP C . n 
C 1 261 GLU 261 257 257 GLU GLU C . n 
C 1 262 ASP 262 258 258 ASP ASP C . n 
C 1 263 GLY 263 259 259 GLY GLY C . n 
C 1 264 ARG 264 260 260 ARG ARG C . n 
C 1 265 SER 265 261 261 SER SER C . n 
C 1 266 LEU 266 262 262 LEU LEU C . n 
C 1 267 LEU 267 263 263 LEU LEU C . n 
C 1 268 SER 268 264 264 SER SER C . n 
C 1 269 GLN 269 265 265 GLN GLN C . n 
C 1 270 MET 270 266 266 MET MET C . n 
C 1 271 LEU 271 267 267 LEU LEU C . n 
C 1 272 HIS 272 268 268 HIS HIS C . n 
C 1 273 TYR 273 269 269 TYR TYR C . n 
C 1 274 ASP 274 270 270 ASP ASP C . n 
C 1 275 PRO 275 271 271 PRO PRO C . n 
C 1 276 ASN 276 272 272 ASN ASN C . n 
C 1 277 LYS 277 273 273 LYS LYS C . n 
C 1 278 ARG 278 274 274 ARG ARG C . n 
C 1 279 ILE 279 275 275 ILE ILE C . n 
C 1 280 SER 280 276 276 SER SER C . n 
C 1 281 ALA 281 277 277 ALA ALA C . n 
C 1 282 LYS 282 278 278 LYS LYS C . n 
C 1 283 ALA 283 279 279 ALA ALA C . n 
C 1 284 ALA 284 280 280 ALA ALA C . n 
C 1 285 LEU 285 281 281 LEU LEU C . n 
C 1 286 ALA 286 282 282 ALA ALA C . n 
C 1 287 HIS 287 283 283 HIS HIS C . n 
C 1 288 PRO 288 284 284 PRO PRO C . n 
C 1 289 PHE 289 285 285 PHE PHE C . n 
C 1 290 PHE 290 286 286 PHE PHE C . n 
C 1 291 GLN 291 287 287 GLN GLN C . n 
C 1 292 ASP 292 288 288 ASP ASP C . n 
C 1 293 VAL 293 289 289 VAL VAL C . n 
C 1 294 THR 294 290 290 THR THR C . n 
C 1 295 LYS 295 291 291 LYS LYS C . n 
C 1 296 PRO 296 292 292 PRO PRO C . n 
C 1 297 VAL 297 293 293 VAL VAL C . n 
C 1 298 PRO 298 294 294 PRO PRO C . n 
C 1 299 HIS 299 295 295 HIS HIS C . n 
C 1 300 LEU 300 296 296 LEU LEU C . n 
C 1 301 ARG 301 297 ?   ?   ?   C . n 
C 1 302 LEU 302 298 ?   ?   ?   C . n 
D 2 1   GLY 1   171 171 GLY GLY D . n 
D 2 2   VAL 2   172 172 VAL VAL D . n 
D 2 3   ASN 3   173 173 ASN ASN D . n 
D 2 4   GLU 4   174 174 GLU GLU D . n 
D 2 5   VAL 5   175 175 VAL VAL D . n 
D 2 6   PRO 6   176 176 PRO PRO D . n 
D 2 7   ASP 7   177 177 ASP ASP D . n 
D 2 8   TYR 8   178 178 TYR TYR D . n 
D 2 9   HIS 9   179 179 HIS HIS D . n 
D 2 10  GLU 10  180 180 GLU GLU D . n 
D 2 11  ASP 11  181 181 ASP ASP D . n 
D 2 12  ILE 12  182 182 ILE ILE D . n 
D 2 13  HIS 13  183 183 HIS HIS D . n 
D 2 14  THR 14  184 184 THR THR D . n 
D 2 15  TYR 15  185 185 TYR TYR D . n 
D 2 16  LEU 16  186 186 LEU LEU D . n 
D 2 17  ARG 17  187 187 ARG ARG D . n 
D 2 18  GLU 18  188 188 GLU GLU D . n 
D 2 19  MET 19  189 189 MET MET D . n 
D 2 20  GLU 20  190 190 GLU GLU D . n 
D 2 21  VAL 21  191 191 VAL VAL D . n 
D 2 22  LYS 22  192 192 LYS LYS D . n 
D 2 23  CYS 23  193 193 CYS CYS D . n 
D 2 24  LYS 24  194 194 LYS LYS D . n 
D 2 25  PRO 25  195 195 PRO PRO D . n 
D 2 26  LYS 26  196 196 LYS LYS D . n 
D 2 27  VAL 27  197 197 VAL VAL D . n 
D 2 28  GLY 28  198 198 GLY GLY D . n 
D 2 29  TYR 29  199 199 TYR TYR D . n 
D 2 30  MET 30  200 200 MET MET D . n 
D 2 31  LYS 31  201 201 LYS LYS D . n 
D 2 32  LYS 32  202 202 LYS LYS D . n 
D 2 33  GLN 33  203 203 GLN GLN D . n 
D 2 34  PRO 34  204 204 PRO PRO D . n 
D 2 35  ASP 35  205 205 ASP ASP D . n 
D 2 36  ILE 36  206 206 ILE ILE D . n 
D 2 37  THR 37  207 207 THR THR D . n 
D 2 38  ASN 38  208 208 ASN ASN D . n 
D 2 39  SER 39  209 209 SER SER D . n 
D 2 40  MET 40  210 210 MET MET D . n 
D 2 41  ARG 41  211 211 ARG ARG D . n 
D 2 42  ALA 42  212 212 ALA ALA D . n 
D 2 43  ILE 43  213 213 ILE ILE D . n 
D 2 44  LEU 44  214 214 LEU LEU D . n 
D 2 45  VAL 45  215 215 VAL VAL D . n 
D 2 46  ASP 46  216 216 ASP ASP D . n 
D 2 47  TRP 47  217 217 TRP TRP D . n 
D 2 48  LEU 48  218 218 LEU LEU D . n 
D 2 49  VAL 49  219 219 VAL VAL D . n 
D 2 50  GLU 50  220 220 GLU GLU D . n 
D 2 51  VAL 51  221 221 VAL VAL D . n 
D 2 52  GLY 52  222 222 GLY GLY D . n 
D 2 53  GLU 53  223 223 GLU GLU D . n 
D 2 54  GLU 54  224 224 GLU GLU D . n 
D 2 55  TYR 55  225 225 TYR TYR D . n 
D 2 56  LYS 56  226 226 LYS LYS D . n 
D 2 57  LEU 57  227 227 LEU LEU D . n 
D 2 58  GLN 58  228 228 GLN GLN D . n 
D 2 59  ASN 59  229 229 ASN ASN D . n 
D 2 60  GLU 60  230 230 GLU GLU D . n 
D 2 61  THR 61  231 231 THR THR D . n 
D 2 62  LEU 62  232 232 LEU LEU D . n 
D 2 63  HIS 63  233 233 HIS HIS D . n 
D 2 64  LEU 64  234 234 LEU LEU D . n 
D 2 65  ALA 65  235 235 ALA ALA D . n 
D 2 66  VAL 66  236 236 VAL VAL D . n 
D 2 67  ASN 67  237 237 ASN ASN D . n 
D 2 68  TYR 68  238 238 TYR TYR D . n 
D 2 69  ILE 69  239 239 ILE ILE D . n 
D 2 70  ASP 70  240 240 ASP ASP D . n 
D 2 71  ARG 71  241 241 ARG ARG D . n 
D 2 72  PHE 72  242 242 PHE PHE D . n 
D 2 73  LEU 73  243 243 LEU LEU D . n 
D 2 74  SER 74  244 244 SER SER D . n 
D 2 75  SER 75  245 245 SER SER D . n 
D 2 76  MET 76  246 246 MET MET D . n 
D 2 77  SER 77  247 247 SER SER D . n 
D 2 78  VAL 78  248 248 VAL VAL D . n 
D 2 79  LEU 79  249 249 LEU LEU D . n 
D 2 80  ARG 80  250 250 ARG ARG D . n 
D 2 81  GLY 81  251 251 GLY GLY D . n 
D 2 82  LYS 82  252 252 LYS LYS D . n 
D 2 83  LEU 83  253 253 LEU LEU D . n 
D 2 84  GLN 84  254 254 GLN GLN D . n 
D 2 85  LEU 85  255 255 LEU LEU D . n 
D 2 86  VAL 86  256 256 VAL VAL D . n 
D 2 87  GLY 87  257 257 GLY GLY D . n 
D 2 88  THR 88  258 258 THR THR D . n 
D 2 89  ALA 89  259 259 ALA ALA D . n 
D 2 90  ALA 90  260 260 ALA ALA D . n 
D 2 91  MET 91  261 261 MET MET D . n 
D 2 92  LEU 92  262 262 LEU LEU D . n 
D 2 93  LEU 93  263 263 LEU LEU D . n 
D 2 94  ALA 94  264 264 ALA ALA D . n 
D 2 95  SER 95  265 265 SER SER D . n 
D 2 96  LYS 96  266 266 LYS LYS D . n 
D 2 97  PHE 97  267 267 PHE PHE D . n 
D 2 98  GLU 98  268 268 GLU GLU D . n 
D 2 99  GLU 99  269 269 GLU GLU D . n 
D 2 100 ILE 100 270 270 ILE ILE D . n 
D 2 101 TYR 101 271 271 TYR TYR D . n 
D 2 102 PRO 102 272 272 PRO PRO D . n 
D 2 103 PRO 103 273 273 PRO PRO D . n 
D 2 104 GLU 104 274 274 GLU GLU D . n 
D 2 105 VAL 105 275 275 VAL VAL D . n 
D 2 106 ALA 106 276 276 ALA ALA D . n 
D 2 107 GLU 107 277 277 GLU GLU D . n 
D 2 108 PHE 108 278 278 PHE PHE D . n 
D 2 109 VAL 109 279 279 VAL VAL D . n 
D 2 110 TYR 110 280 280 TYR TYR D . n 
D 2 111 ILE 111 281 281 ILE ILE D . n 
D 2 112 THR 112 282 282 THR THR D . n 
D 2 113 ASP 113 283 283 ASP ASP D . n 
D 2 114 ASP 114 284 284 ASP ASP D . n 
D 2 115 THR 115 285 285 THR THR D . n 
D 2 116 TYR 116 286 286 TYR TYR D . n 
D 2 117 THR 117 287 287 THR THR D . n 
D 2 118 LYS 118 288 288 LYS LYS D . n 
D 2 119 LYS 119 289 289 LYS LYS D . n 
D 2 120 GLN 120 290 290 GLN GLN D . n 
D 2 121 VAL 121 291 291 VAL VAL D . n 
D 2 122 LEU 122 292 292 LEU LEU D . n 
D 2 123 ARG 123 293 293 ARG ARG D . n 
D 2 124 MET 124 294 294 MET MET D . n 
D 2 125 GLU 125 295 295 GLU GLU D . n 
D 2 126 HIS 126 296 296 HIS HIS D . n 
D 2 127 LEU 127 297 297 LEU LEU D . n 
D 2 128 VAL 128 298 298 VAL VAL D . n 
D 2 129 LEU 129 299 299 LEU LEU D . n 
D 2 130 LYS 130 300 300 LYS LYS D . n 
D 2 131 VAL 131 301 301 VAL VAL D . n 
D 2 132 LEU 132 302 302 LEU LEU D . n 
D 2 133 ALA 133 303 303 ALA ALA D . n 
D 2 134 PHE 134 304 304 PHE PHE D . n 
D 2 135 ASP 135 305 305 ASP ASP D . n 
D 2 136 LEU 136 306 306 LEU LEU D . n 
D 2 137 ALA 137 307 307 ALA ALA D . n 
D 2 138 ALA 138 308 308 ALA ALA D . n 
D 2 139 PRO 139 309 309 PRO PRO D . n 
D 2 140 THR 140 310 310 THR THR D . n 
D 2 141 ILE 141 311 311 ILE ILE D . n 
D 2 142 ASN 142 312 312 ASN ASN D . n 
D 2 143 GLN 143 313 313 GLN GLN D . n 
D 2 144 PHE 144 314 314 PHE PHE D . n 
D 2 145 LEU 145 315 315 LEU LEU D . n 
D 2 146 THR 146 316 316 THR THR D . n 
D 2 147 GLN 147 317 317 GLN GLN D . n 
D 2 148 TYR 148 318 318 TYR TYR D . n 
D 2 149 PHE 149 319 319 PHE PHE D . n 
D 2 150 LEU 150 320 320 LEU LEU D . n 
D 2 151 HIS 151 321 321 HIS HIS D . n 
D 2 152 GLN 152 322 322 GLN GLN D . n 
D 2 153 GLN 153 323 323 GLN GLN D . n 
D 2 154 PRO 154 324 324 PRO PRO D . n 
D 2 155 ALA 155 325 325 ALA ALA D . n 
D 2 156 ASN 156 326 326 ASN ASN D . n 
D 2 157 CYS 157 327 327 CYS CYS D . n 
D 2 158 LYS 158 328 328 LYS LYS D . n 
D 2 159 VAL 159 329 329 VAL VAL D . n 
D 2 160 GLU 160 330 330 GLU GLU D . n 
D 2 161 SER 161 331 331 SER SER D . n 
D 2 162 LEU 162 332 332 LEU LEU D . n 
D 2 163 ALA 163 333 333 ALA ALA D . n 
D 2 164 MET 164 334 334 MET MET D . n 
D 2 165 PHE 165 335 335 PHE PHE D . n 
D 2 166 LEU 166 336 336 LEU LEU D . n 
D 2 167 GLY 167 337 337 GLY GLY D . n 
D 2 168 GLU 168 338 338 GLU GLU D . n 
D 2 169 LEU 169 339 339 LEU LEU D . n 
D 2 170 SER 170 340 340 SER SER D . n 
D 2 171 LEU 171 341 341 LEU LEU D . n 
D 2 172 ILE 172 342 342 ILE ILE D . n 
D 2 173 ASP 173 343 343 ASP ASP D . n 
D 2 174 ALA 174 344 344 ALA ALA D . n 
D 2 175 ASP 175 345 345 ASP ASP D . n 
D 2 176 PRO 176 346 346 PRO PRO D . n 
D 2 177 TYR 177 347 347 TYR TYR D . n 
D 2 178 LEU 178 348 348 LEU LEU D . n 
D 2 179 LYS 179 349 349 LYS LYS D . n 
D 2 180 TYR 180 350 350 TYR TYR D . n 
D 2 181 LEU 181 351 351 LEU LEU D . n 
D 2 182 PRO 182 352 352 PRO PRO D . n 
D 2 183 SER 183 353 353 SER SER D . n 
D 2 184 VAL 184 354 354 VAL VAL D . n 
D 2 185 ILE 185 355 355 ILE ILE D . n 
D 2 186 ALA 186 356 356 ALA ALA D . n 
D 2 187 ALA 187 357 357 ALA ALA D . n 
D 2 188 ALA 188 358 358 ALA ALA D . n 
D 2 189 ALA 189 359 359 ALA ALA D . n 
D 2 190 PHE 190 360 360 PHE PHE D . n 
D 2 191 HIS 191 361 361 HIS HIS D . n 
D 2 192 LEU 192 362 362 LEU LEU D . n 
D 2 193 ALA 193 363 363 ALA ALA D . n 
D 2 194 LEU 194 364 364 LEU LEU D . n 
D 2 195 TYR 195 365 365 TYR TYR D . n 
D 2 196 THR 196 366 366 THR THR D . n 
D 2 197 VAL 197 367 367 VAL VAL D . n 
D 2 198 THR 198 368 368 THR THR D . n 
D 2 199 GLY 199 369 369 GLY GLY D . n 
D 2 200 GLN 200 370 370 GLN GLN D . n 
D 2 201 SER 201 371 371 SER SER D . n 
D 2 202 TRP 202 372 372 TRP TRP D . n 
D 2 203 PRO 203 373 373 PRO PRO D . n 
D 2 204 GLU 204 374 374 GLU GLU D . n 
D 2 205 SER 205 375 375 SER SER D . n 
D 2 206 LEU 206 376 376 LEU LEU D . n 
D 2 207 VAL 207 377 377 VAL VAL D . n 
D 2 208 GLN 208 378 378 GLN GLN D . n 
D 2 209 LYS 209 379 379 LYS LYS D . n 
D 2 210 THR 210 380 380 THR THR D . n 
D 2 211 GLY 211 381 381 GLY GLY D . n 
D 2 212 TYR 212 382 382 TYR TYR D . n 
D 2 213 THR 213 383 383 THR THR D . n 
D 2 214 LEU 214 384 384 LEU LEU D . n 
D 2 215 GLU 215 385 385 GLU GLU D . n 
D 2 216 THR 216 386 386 THR THR D . n 
D 2 217 LEU 217 387 387 LEU LEU D . n 
D 2 218 LYS 218 388 388 LYS LYS D . n 
D 2 219 PRO 219 389 389 PRO PRO D . n 
D 2 220 CYS 220 390 390 CYS CYS D . n 
D 2 221 LEU 221 391 391 LEU LEU D . n 
D 2 222 LEU 222 392 392 LEU LEU D . n 
D 2 223 ASP 223 393 393 ASP ASP D . n 
D 2 224 LEU 224 394 394 LEU LEU D . n 
D 2 225 HIS 225 395 395 HIS HIS D . n 
D 2 226 GLN 226 396 396 GLN GLN D . n 
D 2 227 THR 227 397 397 THR THR D . n 
D 2 228 TYR 228 398 398 TYR TYR D . n 
D 2 229 LEU 229 399 399 LEU LEU D . n 
D 2 230 ARG 230 400 400 ARG ARG D . n 
D 2 231 ALA 231 401 401 ALA ALA D . n 
D 2 232 PRO 232 402 402 PRO PRO D . n 
D 2 233 GLN 233 403 403 GLN GLN D . n 
D 2 234 HIS 234 404 404 HIS HIS D . n 
D 2 235 ALA 235 405 405 ALA ALA D . n 
D 2 236 GLN 236 406 406 GLN GLN D . n 
D 2 237 GLN 237 407 407 GLN GLN D . n 
D 2 238 SER 238 408 408 SER SER D . n 
D 2 239 ILE 239 409 409 ILE ILE D . n 
D 2 240 ARG 240 410 410 ARG ARG D . n 
D 2 241 GLU 241 411 411 GLU GLU D . n 
D 2 242 LYS 242 412 412 LYS LYS D . n 
D 2 243 TYR 243 413 413 TYR TYR D . n 
D 2 244 LYS 244 414 414 LYS LYS D . n 
D 2 245 ASN 245 415 415 ASN ASN D . n 
D 2 246 SER 246 416 416 SER SER D . n 
D 2 247 LYS 247 417 417 LYS LYS D . n 
D 2 248 TYR 248 418 418 TYR TYR D . n 
D 2 249 HIS 249 419 419 HIS HIS D . n 
D 2 250 GLY 250 420 420 GLY GLY D . n 
D 2 251 VAL 251 421 421 VAL VAL D . n 
D 2 252 SER 252 422 422 SER SER D . n 
D 2 253 LEU 253 423 423 LEU LEU D . n 
D 2 254 LEU 254 424 424 LEU LEU D . n 
D 2 255 ASN 255 425 425 ASN ASN D . n 
D 2 256 PRO 256 426 426 PRO PRO D . n 
D 2 257 PRO 257 427 427 PRO PRO D . n 
D 2 258 GLU 258 428 428 GLU GLU D . n 
D 2 259 THR 259 429 429 THR THR D . n 
D 2 260 LEU 260 430 430 LEU LEU D . n 
D 2 261 ASN 261 431 431 ASN ASN D . n 
D 2 262 VAL 262 432 432 VAL VAL D . n 
D 2 263 HIS 263 433 ?   ?   ?   D . n 
D 2 264 HIS 264 434 ?   ?   ?   D . n 
D 2 265 HIS 265 435 ?   ?   ?   D . n 
D 2 266 HIS 266 436 ?   ?   ?   D . n 
D 2 267 HIS 267 437 ?   ?   ?   D . n 
D 2 268 HIS 268 438 ?   ?   ?   D . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        IJF 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   IJF 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 IJF 1   301 703 IJF DRG A . 
F 3 IJF 1   302 704 IJF DRG A . 
G 3 IJF 1   303 705 IJF DRG A . 
H 3 IJF 1   304 710 IJF DRG A . 
I 3 IJF 1   701 701 IJF DRG B . 
J 3 IJF 1   702 706 IJF DRG B . 
K 3 IJF 1   703 713 IJF DRG B . 
L 3 IJF 1   301 707 IJF DRG C . 
M 3 IJF 1   302 708 IJF DRG C . 
N 3 IJF 1   303 711 IJF DRG C . 
O 3 IJF 1   304 701 IJF DRG C . 
P 3 IJF 1   501 702 IJF DRG D . 
Q 4 HOH 1   401 421 HOH HOH A . 
Q 4 HOH 2   402 408 HOH HOH A . 
Q 4 HOH 3   403 460 HOH HOH A . 
Q 4 HOH 4   404 417 HOH HOH A . 
Q 4 HOH 5   405 525 HOH HOH A . 
Q 4 HOH 6   406 404 HOH HOH A . 
Q 4 HOH 7   407 456 HOH HOH A . 
Q 4 HOH 8   408 11  HOH HOH A . 
Q 4 HOH 9   409 453 HOH HOH A . 
Q 4 HOH 10  410 440 HOH HOH A . 
Q 4 HOH 11  411 520 HOH HOH A . 
Q 4 HOH 12  412 444 HOH HOH A . 
Q 4 HOH 13  413 423 HOH HOH A . 
Q 4 HOH 14  414 431 HOH HOH A . 
Q 4 HOH 15  415 499 HOH HOH A . 
Q 4 HOH 16  416 479 HOH HOH A . 
Q 4 HOH 17  417 436 HOH HOH A . 
Q 4 HOH 18  418 515 HOH HOH A . 
Q 4 HOH 19  419 432 HOH HOH A . 
Q 4 HOH 20  420 525 HOH HOH A . 
Q 4 HOH 21  421 475 HOH HOH A . 
Q 4 HOH 22  422 459 HOH HOH A . 
Q 4 HOH 23  423 425 HOH HOH A . 
Q 4 HOH 24  424 545 HOH HOH A . 
Q 4 HOH 25  425 474 HOH HOH A . 
Q 4 HOH 26  426 580 HOH HOH A . 
Q 4 HOH 27  427 434 HOH HOH A . 
Q 4 HOH 28  428 477 HOH HOH A . 
Q 4 HOH 29  429 430 HOH HOH A . 
Q 4 HOH 30  430 451 HOH HOH A . 
Q 4 HOH 31  431 464 HOH HOH A . 
Q 4 HOH 32  432 401 HOH HOH A . 
Q 4 HOH 33  433 585 HOH HOH A . 
Q 4 HOH 34  434 478 HOH HOH A . 
Q 4 HOH 35  435 486 HOH HOH A . 
Q 4 HOH 36  436 420 HOH HOH A . 
Q 4 HOH 37  437 410 HOH HOH A . 
Q 4 HOH 38  438 504 HOH HOH A . 
Q 4 HOH 39  439 433 HOH HOH A . 
Q 4 HOH 40  440 506 HOH HOH A . 
Q 4 HOH 41  441 470 HOH HOH A . 
Q 4 HOH 42  442 490 HOH HOH A . 
Q 4 HOH 43  443 452 HOH HOH A . 
Q 4 HOH 44  444 491 HOH HOH A . 
Q 4 HOH 45  445 411 HOH HOH A . 
Q 4 HOH 46  446 482 HOH HOH A . 
Q 4 HOH 47  447 461 HOH HOH A . 
Q 4 HOH 48  448 467 HOH HOH A . 
Q 4 HOH 49  449 426 HOH HOH A . 
Q 4 HOH 50  450 509 HOH HOH A . 
Q 4 HOH 51  451 428 HOH HOH A . 
Q 4 HOH 52  452 448 HOH HOH A . 
Q 4 HOH 53  453 472 HOH HOH A . 
Q 4 HOH 54  454 462 HOH HOH A . 
Q 4 HOH 55  455 522 HOH HOH A . 
Q 4 HOH 56  456 487 HOH HOH A . 
Q 4 HOH 57  457 427 HOH HOH A . 
Q 4 HOH 58  458 528 HOH HOH A . 
Q 4 HOH 59  459 480 HOH HOH A . 
Q 4 HOH 60  460 495 HOH HOH A . 
Q 4 HOH 61  461 435 HOH HOH A . 
Q 4 HOH 62  462 416 HOH HOH A . 
Q 4 HOH 63  463 483 HOH HOH A . 
Q 4 HOH 64  464 527 HOH HOH A . 
Q 4 HOH 65  465 558 HOH HOH A . 
Q 4 HOH 66  466 481 HOH HOH A . 
Q 4 HOH 67  467 523 HOH HOH A . 
Q 4 HOH 68  468 517 HOH HOH A . 
Q 4 HOH 69  469 503 HOH HOH A . 
Q 4 HOH 70  470 457 HOH HOH A . 
Q 4 HOH 71  471 511 HOH HOH A . 
Q 4 HOH 72  472 20  HOH HOH A . 
Q 4 HOH 73  473 429 HOH HOH A . 
Q 4 HOH 74  474 556 HOH HOH A . 
Q 4 HOH 75  475 612 HOH HOH A . 
Q 4 HOH 76  476 405 HOH HOH A . 
Q 4 HOH 77  477 403 HOH HOH A . 
Q 4 HOH 78  478 484 HOH HOH A . 
Q 4 HOH 79  479 502 HOH HOH A . 
Q 4 HOH 80  480 546 HOH HOH A . 
Q 4 HOH 81  481 439 HOH HOH A . 
Q 4 HOH 82  482 554 HOH HOH A . 
Q 4 HOH 83  483 447 HOH HOH A . 
Q 4 HOH 84  484 489 HOH HOH A . 
Q 4 HOH 85  485 507 HOH HOH A . 
Q 4 HOH 86  486 524 HOH HOH A . 
Q 4 HOH 87  487 541 HOH HOH A . 
Q 4 HOH 88  488 544 HOH HOH A . 
Q 4 HOH 89  489 526 HOH HOH A . 
Q 4 HOH 90  490 466 HOH HOH A . 
Q 4 HOH 91  491 571 HOH HOH A . 
Q 4 HOH 92  492 23  HOH HOH A . 
Q 4 HOH 93  493 532 HOH HOH A . 
Q 4 HOH 94  494 539 HOH HOH A . 
Q 4 HOH 95  495 552 HOH HOH A . 
Q 4 HOH 96  496 443 HOH HOH A . 
Q 4 HOH 97  497 535 HOH HOH A . 
Q 4 HOH 98  498 534 HOH HOH A . 
Q 4 HOH 99  499 402 HOH HOH A . 
Q 4 HOH 100 500 501 HOH HOH A . 
Q 4 HOH 101 501 559 HOH HOH A . 
Q 4 HOH 102 502 553 HOH HOH A . 
Q 4 HOH 103 503 21  HOH HOH A . 
Q 4 HOH 104 504 569 HOH HOH A . 
Q 4 HOH 105 505 578 HOH HOH A . 
Q 4 HOH 106 506 437 HOH HOH A . 
Q 4 HOH 107 507 576 HOH HOH A . 
Q 4 HOH 108 508 582 HOH HOH A . 
Q 4 HOH 109 509 536 HOH HOH A . 
Q 4 HOH 110 510 574 HOH HOH A . 
Q 4 HOH 111 511 562 HOH HOH A . 
Q 4 HOH 112 512 508 HOH HOH A . 
Q 4 HOH 113 513 592 HOH HOH A . 
Q 4 HOH 114 514 586 HOH HOH A . 
Q 4 HOH 115 515 588 HOH HOH A . 
Q 4 HOH 116 516 594 HOH HOH A . 
R 4 HOH 1   801 507 HOH HOH B . 
R 4 HOH 2   802 642 HOH HOH B . 
R 4 HOH 3   803 523 HOH HOH B . 
R 4 HOH 4   804 537 HOH HOH B . 
R 4 HOH 5   805 547 HOH HOH B . 
R 4 HOH 6   806 553 HOH HOH B . 
R 4 HOH 7   807 585 HOH HOH B . 
R 4 HOH 8   808 506 HOH HOH B . 
R 4 HOH 9   809 509 HOH HOH B . 
R 4 HOH 10  810 568 HOH HOH B . 
R 4 HOH 11  811 551 HOH HOH B . 
R 4 HOH 12  812 510 HOH HOH B . 
R 4 HOH 13  813 531 HOH HOH B . 
R 4 HOH 14  814 555 HOH HOH B . 
R 4 HOH 15  815 542 HOH HOH B . 
R 4 HOH 16  816 571 HOH HOH B . 
R 4 HOH 17  817 566 HOH HOH B . 
R 4 HOH 18  818 622 HOH HOH B . 
R 4 HOH 19  819 543 HOH HOH B . 
R 4 HOH 20  820 644 HOH HOH B . 
R 4 HOH 21  821 524 HOH HOH B . 
R 4 HOH 22  822 586 HOH HOH B . 
R 4 HOH 23  823 572 HOH HOH B . 
R 4 HOH 24  824 508 HOH HOH B . 
R 4 HOH 25  825 678 HOH HOH B . 
R 4 HOH 26  826 564 HOH HOH B . 
R 4 HOH 27  827 560 HOH HOH B . 
R 4 HOH 28  828 528 HOH HOH B . 
R 4 HOH 29  829 556 HOH HOH B . 
R 4 HOH 30  830 659 HOH HOH B . 
R 4 HOH 31  831 595 HOH HOH B . 
R 4 HOH 32  832 545 HOH HOH B . 
R 4 HOH 33  833 532 HOH HOH B . 
R 4 HOH 34  834 579 HOH HOH B . 
R 4 HOH 35  835 594 HOH HOH B . 
R 4 HOH 36  836 557 HOH HOH B . 
R 4 HOH 37  837 574 HOH HOH B . 
R 4 HOH 38  838 624 HOH HOH B . 
R 4 HOH 39  839 525 HOH HOH B . 
R 4 HOH 40  840 593 HOH HOH B . 
R 4 HOH 41  841 601 HOH HOH B . 
R 4 HOH 42  842 558 HOH HOH B . 
R 4 HOH 43  843 554 HOH HOH B . 
R 4 HOH 44  844 609 HOH HOH B . 
R 4 HOH 45  845 520 HOH HOH B . 
R 4 HOH 46  846 529 HOH HOH B . 
R 4 HOH 47  847 605 HOH HOH B . 
R 4 HOH 48  848 607 HOH HOH B . 
R 4 HOH 49  849 630 HOH HOH B . 
R 4 HOH 50  850 548 HOH HOH B . 
R 4 HOH 51  851 587 HOH HOH B . 
R 4 HOH 52  852 590 HOH HOH B . 
R 4 HOH 53  853 589 HOH HOH B . 
R 4 HOH 54  854 633 HOH HOH B . 
R 4 HOH 55  855 608 HOH HOH B . 
R 4 HOH 56  856 511 HOH HOH B . 
R 4 HOH 57  857 567 HOH HOH B . 
R 4 HOH 58  858 598 HOH HOH B . 
R 4 HOH 59  859 512 HOH HOH B . 
R 4 HOH 60  860 618 HOH HOH B . 
R 4 HOH 61  861 643 HOH HOH B . 
R 4 HOH 62  862 4   HOH HOH B . 
R 4 HOH 63  863 623 HOH HOH B . 
R 4 HOH 64  864 546 HOH HOH B . 
R 4 HOH 65  865 577 HOH HOH B . 
R 4 HOH 66  866 521 HOH HOH B . 
R 4 HOH 67  867 628 HOH HOH B . 
R 4 HOH 68  868 596 HOH HOH B . 
R 4 HOH 69  869 616 HOH HOH B . 
R 4 HOH 70  870 588 HOH HOH B . 
R 4 HOH 71  871 615 HOH HOH B . 
R 4 HOH 72  872 563 HOH HOH B . 
R 4 HOH 73  873 631 HOH HOH B . 
R 4 HOH 74  874 638 HOH HOH B . 
R 4 HOH 75  875 582 HOH HOH B . 
R 4 HOH 76  876 625 HOH HOH B . 
R 4 HOH 77  877 627 HOH HOH B . 
R 4 HOH 78  878 637 HOH HOH B . 
R 4 HOH 79  879 617 HOH HOH B . 
R 4 HOH 80  880 538 HOH HOH B . 
R 4 HOH 81  881 636 HOH HOH B . 
R 4 HOH 82  882 619 HOH HOH B . 
R 4 HOH 83  883 620 HOH HOH B . 
R 4 HOH 84  884 641 HOH HOH B . 
R 4 HOH 85  885 539 HOH HOH B . 
R 4 HOH 86  886 629 HOH HOH B . 
R 4 HOH 87  887 639 HOH HOH B . 
R 4 HOH 88  888 656 HOH HOH B . 
R 4 HOH 89  889 640 HOH HOH B . 
R 4 HOH 90  890 559 HOH HOH B . 
R 4 HOH 91  891 667 HOH HOH B . 
R 4 HOH 92  892 581 HOH HOH B . 
R 4 HOH 93  893 663 HOH HOH B . 
R 4 HOH 94  894 657 HOH HOH B . 
R 4 HOH 95  895 650 HOH HOH B . 
R 4 HOH 96  896 662 HOH HOH B . 
R 4 HOH 97  897 673 HOH HOH B . 
R 4 HOH 98  898 665 HOH HOH B . 
R 4 HOH 99  899 653 HOH HOH B . 
R 4 HOH 100 900 671 HOH HOH B . 
R 4 HOH 101 901 635 HOH HOH B . 
R 4 HOH 102 902 676 HOH HOH B . 
R 4 HOH 103 903 672 HOH HOH B . 
R 4 HOH 104 904 647 HOH HOH B . 
R 4 HOH 105 905 680 HOH HOH B . 
R 4 HOH 106 906 679 HOH HOH B . 
S 4 HOH 1   401 418 HOH HOH C . 
S 4 HOH 2   402 405 HOH HOH C . 
S 4 HOH 3   403 409 HOH HOH C . 
S 4 HOH 4   404 417 HOH HOH C . 
S 4 HOH 5   405 406 HOH HOH C . 
S 4 HOH 6   406 407 HOH HOH C . 
S 4 HOH 7   407 422 HOH HOH C . 
S 4 HOH 8   408 455 HOH HOH C . 
S 4 HOH 9   409 414 HOH HOH C . 
S 4 HOH 10  410 430 HOH HOH C . 
S 4 HOH 11  411 432 HOH HOH C . 
S 4 HOH 12  412 438 HOH HOH C . 
S 4 HOH 13  413 412 HOH HOH C . 
S 4 HOH 14  414 410 HOH HOH C . 
S 4 HOH 15  415 419 HOH HOH C . 
S 4 HOH 16  416 431 HOH HOH C . 
S 4 HOH 17  417 437 HOH HOH C . 
S 4 HOH 18  418 452 HOH HOH C . 
S 4 HOH 19  419 448 HOH HOH C . 
S 4 HOH 20  420 428 HOH HOH C . 
S 4 HOH 21  421 433 HOH HOH C . 
S 4 HOH 22  422 460 HOH HOH C . 
S 4 HOH 23  423 446 HOH HOH C . 
S 4 HOH 24  424 424 HOH HOH C . 
S 4 HOH 25  425 7   HOH HOH C . 
S 4 HOH 26  426 449 HOH HOH C . 
S 4 HOH 27  427 427 HOH HOH C . 
S 4 HOH 28  428 401 HOH HOH C . 
S 4 HOH 29  429 453 HOH HOH C . 
S 4 HOH 30  430 451 HOH HOH C . 
S 4 HOH 31  431 445 HOH HOH C . 
S 4 HOH 32  432 436 HOH HOH C . 
S 4 HOH 33  433 447 HOH HOH C . 
S 4 HOH 34  434 426 HOH HOH C . 
S 4 HOH 35  435 462 HOH HOH C . 
S 4 HOH 36  436 461 HOH HOH C . 
S 4 HOH 37  437 468 HOH HOH C . 
S 4 HOH 38  438 26  HOH HOH C . 
S 4 HOH 39  439 25  HOH HOH C . 
S 4 HOH 40  440 421 HOH HOH C . 
S 4 HOH 41  441 15  HOH HOH C . 
S 4 HOH 42  442 429 HOH HOH C . 
S 4 HOH 43  443 442 HOH HOH C . 
S 4 HOH 44  444 459 HOH HOH C . 
S 4 HOH 45  445 469 HOH HOH C . 
S 4 HOH 46  446 473 HOH HOH C . 
S 4 HOH 47  447 572 HOH HOH C . 
S 4 HOH 48  448 477 HOH HOH C . 
S 4 HOH 49  449 474 HOH HOH C . 
T 4 HOH 1   601 522 HOH HOH D . 
T 4 HOH 2   602 521 HOH HOH D . 
T 4 HOH 3   603 511 HOH HOH D . 
T 4 HOH 4   604 550 HOH HOH D . 
T 4 HOH 5   605 506 HOH HOH D . 
T 4 HOH 6   606 529 HOH HOH D . 
T 4 HOH 7   607 509 HOH HOH D . 
T 4 HOH 8   608 512 HOH HOH D . 
T 4 HOH 9   609 526 HOH HOH D . 
T 4 HOH 10  610 435 HOH HOH D . 
T 4 HOH 11  611 507 HOH HOH D . 
T 4 HOH 12  612 524 HOH HOH D . 
T 4 HOH 13  613 532 HOH HOH D . 
T 4 HOH 14  614 520 HOH HOH D . 
T 4 HOH 15  615 504 HOH HOH D . 
T 4 HOH 16  616 565 HOH HOH D . 
T 4 HOH 17  617 515 HOH HOH D . 
T 4 HOH 18  618 539 HOH HOH D . 
T 4 HOH 19  619 544 HOH HOH D . 
T 4 HOH 20  620 554 HOH HOH D . 
T 4 HOH 21  621 533 HOH HOH D . 
T 4 HOH 22  622 566 HOH HOH D . 
T 4 HOH 23  623 517 HOH HOH D . 
T 4 HOH 24  624 523 HOH HOH D . 
T 4 HOH 25  625 561 HOH HOH D . 
T 4 HOH 26  626 538 HOH HOH D . 
T 4 HOH 27  627 562 HOH HOH D . 
T 4 HOH 28  628 536 HOH HOH D . 
T 4 HOH 29  629 543 HOH HOH D . 
T 4 HOH 30  630 568 HOH HOH D . 
T 4 HOH 31  631 553 HOH HOH D . 
T 4 HOH 32  632 578 HOH HOH D . 
T 4 HOH 33  633 514 HOH HOH D . 
T 4 HOH 34  634 558 HOH HOH D . 
T 4 HOH 35  635 560 HOH HOH D . 
T 4 HOH 36  636 569 HOH HOH D . 
T 4 HOH 37  637 577 HOH HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0425 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2    ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        4 
# 
_cell.angle_alpha                  90 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9ESW 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     74.125 
_cell.length_a_esd                 ? 
_cell.length_b                     134.031 
_cell.length_b_esd                 ? 
_cell.length_c                     147.881 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9ESW 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9ESW 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.82 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.35 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'Protein at 10 mg/ml. 0.6 to 0.8 M KCl, 0.9 to 1.2 M (NH4)2SO4, and 100 mM HEPES pH 7.0' 
_exptl_crystal_grow.pdbx_pH_range   7-7.5 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-02-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.89842 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.89842 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9ESW 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.38 
_reflns.d_resolution_low                               147.88 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     56875 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           94.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.166 
_reflns.pdbx_Rpim_I_all                                0.062 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.154 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
10.1 147.88 ? 44.2 ? ? ? ? 913  ? ? ? ? ? ? ? ? ? ? ? ?    ? ? ? 0.034 0.012 ? 1 1 1     ? ? ?   ? 0.032 ? ? ? ? ? ? ? ? ? 
2.38 2.45   ? 1.2  ? ? ? ? 4846 ? ? ? ? ? ? ? ? ? ? ? 13.4 ? ? ? 2.214 0.838 ? 2 1 0.593 ? ? 100 ? 2.048 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            -2.447 
_refine.aniso_B[1][2]                            0.000 
_refine.aniso_B[1][3]                            0.000 
_refine.aniso_B[2][2]                            0.838 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            1.609 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               38.610 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.949 
_refine.correlation_coeff_Fo_to_Fc_free          0.932 
_refine.details                                  'Hydrogens have not been used' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9ESW 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.380 
_refine.ls_d_res_low                             99.508 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     56222 
_refine.ls_number_reflns_R_free                  2868 
_refine.ls_number_reflns_R_work                  53354 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    93.966 
_refine.ls_percent_reflns_R_free                 5.101 
_refine.ls_R_factor_all                          0.233 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2390 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2324 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      0.226 
_refine.ls_wR_factor_R_work                      0.216 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.436 
_refine.pdbx_overall_ESU_R_Free                  0.247 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    0.9474 
_refine.pdbx_average_fsc_free                    0.9455 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.380 
_refine_hist.d_res_low                        99.508 
_refine_hist.number_atoms_solvent             308 
_refine_hist.number_atoms_total               9188 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        8772 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         108 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.012  9213  ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 1.632  1.846  12497 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.222  5.000  1097  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 19.222 5.000  43    ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 15.233 10.000 1586  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 15.818 10.000 393   ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.098  0.200  1398  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.020  6911  ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.224  0.200  4344  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.319  0.200  6225  ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.150  0.200  405   ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.299  0.200  69    ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.195  0.200  12    ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 3.879  3.692  4388  ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 5.925  6.622  5485  ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.351  3.968  4825  ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 7.793  7.130  7012  ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 10.407 41.683 14081 ? r_lrange_it                    ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.380  2.442  4328 . 211 4117 100.0000 . 0.379 . . 0.378 . . . . . 0.383 . 20 . 0.900 0.897 0.391 
'X-RAY DIFFRACTION' 2.442  2.509  4283 . 237 4046 100.0000 . 0.356 . . 0.356 . . . . . 0.360 . 20 . 0.909 0.914 0.353 
'X-RAY DIFFRACTION' 2.509  2.581  4139 . 219 3920 100.0000 . 0.329 . . 0.331 . . . . . 0.331 . 20 . 0.917 0.924 0.308 
'X-RAY DIFFRACTION' 2.581  2.661  4025 . 152 2916 76.2236  . 0.677 . . 0.675 . . . . . 0.862 . 20 . 0.891 0.879 0.724 
'X-RAY DIFFRACTION' 2.661  2.748  3910 . 133 2606 70.0512  . 0.303 . . 0.303 . . . . . 0.295 . 20 . 0.941 0.940 0.306 
'X-RAY DIFFRACTION' 2.748  2.844  3786 . 187 3599 100.0000 . 0.293 . . 0.294 . . . . . 0.285 . 20 . 0.943 0.954 0.271 
'X-RAY DIFFRACTION' 2.844  2.952  3653 . 185 3468 100.0000 . 0.283 . . 0.282 . . . . . 0.269 . 20 . 0.949 0.940 0.302 
'X-RAY DIFFRACTION' 2.952  3.072  3516 . 195 3321 100.0000 . 0.272 . . 0.271 . . . . . 0.259 . 20 . 0.954 0.950 0.274 
'X-RAY DIFFRACTION' 3.072  3.208  3374 . 169 3205 100.0000 . 0.254 . . 0.253 . . . . . 0.239 . 20 . 0.960 0.958 0.262 
'X-RAY DIFFRACTION' 3.208  3.365  3247 . 156 3091 100.0000 . 0.246 . . 0.245 . . . . . 0.231 . 20 . 0.962 0.958 0.265 
'X-RAY DIFFRACTION' 3.365  3.547  3093 . 136 2393 81.7653  . 0.225 . . 0.226 . . . . . 0.216 . 20 . 0.970 0.972 0.220 
'X-RAY DIFFRACTION' 3.547  3.762  2914 . 133 2343 84.9691  . 0.215 . . 0.216 . . . . . 0.208 . 20 . 0.972 0.979 0.197 
'X-RAY DIFFRACTION' 3.762  4.021  2769 . 106 2185 82.7374  . 0.210 . . 0.210 . . . . . 0.200 . 20 . 0.973 0.974 0.211 
'X-RAY DIFFRACTION' 4.021  4.342  2589 . 139 2450 100.0000 . 0.182 . . 0.182 . . . . . 0.176 . 20 . 0.981 0.981 0.186 
'X-RAY DIFFRACTION' 4.342  4.756  2368 . 129 2239 100.0000 . 0.178 . . 0.177 . . . . . 0.173 . 20 . 0.982 0.981 0.181 
'X-RAY DIFFRACTION' 4.756  5.316  2174 . 92  2082 100.0000 . 0.188 . . 0.188 . . . . . 0.181 . 20 . 0.979 0.975 0.197 
'X-RAY DIFFRACTION' 5.316  6.135  1929 . 103 1826 100.0000 . 0.220 . . 0.219 . . . . . 0.212 . 20 . 0.975 0.972 0.228 
'X-RAY DIFFRACTION' 6.135  7.507  1646 . 90  1556 100.0000 . 0.213 . . 0.212 . . . . . 0.207 . 20 . 0.976 0.972 0.220 
'X-RAY DIFFRACTION' 7.507  10.586 1314 . 59  1255 100.0000 . 0.159 . . 0.159 . . . . . 0.161 . 20 . 0.985 0.981 0.180 
'X-RAY DIFFRACTION' 10.586 99.508 775  . 37  736  99.7419  . 0.229 . . 0.227 . . . . . 0.257 . 20 . 0.964 0.870 0.300 
# 
_struct.entry_id                     9ESW 
_struct.title                        'CDK2-cyclin A in complex with FragLite 18' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9ESW 
_struct_keywords.text            'cyclin-dependent kinase, FragLite, CDK2, cyclin A, Fragment, CELL CYCLE' 
_struct_keywords.pdbx_keywords   'CELL CYCLE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 3 ? 
I N N 3 ? 
J N N 3 ? 
K N N 3 ? 
L N N 3 ? 
M N N 3 ? 
N N N 3 ? 
O N N 3 ? 
P N N 3 ? 
Q N N 4 ? 
R N N 4 ? 
S N N 4 ? 
T N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP CDK2_HUMAN  P24941 ? 1 
;MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
;
1   
2 UNP CCNA2_BOVIN P30274 ? 2 
;VNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRG
KLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVES
LAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIRE
KYKNSKYHGVSLLNPPETLNV
;
170 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9ESW A 5 ? 302 ? P24941 1   ? 298 ? 1   298 
2 2 9ESW B 2 ? 262 ? P30274 170 ? 430 ? 172 432 
3 1 9ESW C 5 ? 302 ? P24941 1   ? 298 ? 1   298 
4 2 9ESW D 2 ? 262 ? P30274 170 ? 430 ? 172 432 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9ESW GLY A 1   ? UNP P24941 ? ? 'expression tag' -3  1  
1 9ESW PRO A 2   ? UNP P24941 ? ? 'expression tag' -2  2  
1 9ESW GLY A 3   ? UNP P24941 ? ? 'expression tag' -1  3  
1 9ESW SER A 4   ? UNP P24941 ? ? 'expression tag' 0   4  
2 9ESW GLY B 1   ? UNP P30274 ? ? 'expression tag' 171 5  
2 9ESW HIS B 263 ? UNP P30274 ? ? 'expression tag' 433 6  
2 9ESW HIS B 264 ? UNP P30274 ? ? 'expression tag' 434 7  
2 9ESW HIS B 265 ? UNP P30274 ? ? 'expression tag' 435 8  
2 9ESW HIS B 266 ? UNP P30274 ? ? 'expression tag' 436 9  
2 9ESW HIS B 267 ? UNP P30274 ? ? 'expression tag' 437 10 
2 9ESW HIS B 268 ? UNP P30274 ? ? 'expression tag' 438 11 
3 9ESW GLY C 1   ? UNP P24941 ? ? 'expression tag' -3  12 
3 9ESW PRO C 2   ? UNP P24941 ? ? 'expression tag' -2  13 
3 9ESW GLY C 3   ? UNP P24941 ? ? 'expression tag' -1  14 
3 9ESW SER C 4   ? UNP P24941 ? ? 'expression tag' 0   15 
4 9ESW GLY D 1   ? UNP P30274 ? ? 'expression tag' 171 16 
4 9ESW HIS D 263 ? UNP P30274 ? ? 'expression tag' 433 17 
4 9ESW HIS D 264 ? UNP P30274 ? ? 'expression tag' 434 18 
4 9ESW HIS D 265 ? UNP P30274 ? ? 'expression tag' 435 19 
4 9ESW HIS D 266 ? UNP P30274 ? ? 'expression tag' 436 20 
4 9ESW HIS D 267 ? UNP P30274 ? ? 'expression tag' 437 21 
4 9ESW HIS D 268 ? UNP P30274 ? ? 'expression tag' 438 22 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3500  ? 
1 MORE         -15   ? 
1 'SSA (A^2)'  23250 ? 
2 'ABSA (A^2)' 3740  ? 
2 MORE         -16   ? 
2 'SSA (A^2)'  22460 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,E,F,G,H,I,J,K,Q,R 
2 1 C,D,L,M,N,O,P,S,T     
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 4   ? GLU A 6   ? SER A 0   GLU A 2   5 ? 3  
HELX_P HELX_P2  AA2 PRO A 49  ? GLU A 61  ? PRO A 45  GLU A 57  1 ? 13 
HELX_P HELX_P3  AA3 LEU A 91  ? SER A 98  ? LEU A 87  SER A 94  1 ? 8  
HELX_P HELX_P4  AA4 PRO A 104 ? SER A 124 ? PRO A 100 SER A 120 1 ? 21 
HELX_P HELX_P5  AA5 LYS A 133 ? GLN A 135 ? LYS A 129 GLN A 131 5 ? 3  
HELX_P HELX_P6  AA6 THR A 169 ? ARG A 173 ? THR A 165 ARG A 169 5 ? 5  
HELX_P HELX_P7  AA7 ALA A 174 ? LEU A 179 ? ALA A 170 LEU A 175 1 ? 6  
HELX_P HELX_P8  AA8 THR A 186 ? ARG A 203 ? THR A 182 ARG A 199 1 ? 18 
HELX_P HELX_P9  AA9 SER A 211 ? GLY A 224 ? SER A 207 GLY A 220 1 ? 14 
HELX_P HELX_P10 AB1 GLY A 233 ? MET A 237 ? GLY A 229 MET A 233 5 ? 5  
HELX_P HELX_P11 AB2 ASP A 251 ? VAL A 255 ? ASP A 247 VAL A 251 5 ? 5  
HELX_P HELX_P12 AB3 ASP A 260 ? LEU A 271 ? ASP A 256 LEU A 267 1 ? 12 
HELX_P HELX_P13 AB4 SER A 280 ? LEU A 285 ? SER A 276 LEU A 281 1 ? 6  
HELX_P HELX_P14 AB5 ALA A 286 ? GLN A 291 ? ALA A 282 GLN A 287 5 ? 6  
HELX_P HELX_P15 AB6 GLY B 1   ? VAL B 5   ? GLY B 171 VAL B 175 5 ? 5  
HELX_P HELX_P16 AB7 TYR B 8   ? CYS B 23  ? TYR B 178 CYS B 193 1 ? 16 
HELX_P HELX_P17 AB8 TYR B 29  ? GLN B 33  ? TYR B 199 GLN B 203 5 ? 5  
HELX_P HELX_P18 AB9 THR B 37  ? TYR B 55  ? THR B 207 TYR B 225 1 ? 19 
HELX_P HELX_P19 AC1 GLN B 58  ? MET B 76  ? GLN B 228 MET B 246 1 ? 19 
HELX_P HELX_P20 AC2 LEU B 79  ? GLY B 81  ? LEU B 249 GLY B 251 5 ? 3  
HELX_P HELX_P21 AC3 LYS B 82  ? GLU B 99  ? LYS B 252 GLU B 269 1 ? 18 
HELX_P HELX_P22 AC4 GLU B 104 ? THR B 112 ? GLU B 274 THR B 282 1 ? 9  
HELX_P HELX_P23 AC5 THR B 117 ? ALA B 133 ? THR B 287 ALA B 303 1 ? 17 
HELX_P HELX_P24 AC6 THR B 140 ? LEU B 150 ? THR B 310 LEU B 320 1 ? 11 
HELX_P HELX_P25 AC7 ASN B 156 ? ILE B 172 ? ASN B 326 ILE B 342 1 ? 17 
HELX_P HELX_P26 AC8 ASP B 173 ? LEU B 178 ? ASP B 343 LEU B 348 1 ? 6  
HELX_P HELX_P27 AC9 LEU B 181 ? GLY B 199 ? LEU B 351 GLY B 369 1 ? 19 
HELX_P HELX_P28 AD1 PRO B 203 ? GLY B 211 ? PRO B 373 GLY B 381 1 ? 9  
HELX_P HELX_P29 AD2 THR B 213 ? ALA B 231 ? THR B 383 ALA B 401 1 ? 19 
HELX_P HELX_P30 AD3 GLN B 237 ? TYR B 243 ? GLN B 407 TYR B 413 1 ? 7  
HELX_P HELX_P31 AD4 LYS B 244 ? HIS B 249 ? LYS B 414 HIS B 419 5 ? 6  
HELX_P HELX_P32 AD5 GLY B 250 ? LEU B 254 ? GLY B 420 LEU B 424 5 ? 5  
HELX_P HELX_P33 AD6 PRO C 49  ? GLU C 61  ? PRO C 45  GLU C 57  1 ? 13 
HELX_P HELX_P34 AD7 LEU C 91  ? SER C 98  ? LEU C 87  SER C 94  1 ? 8  
HELX_P HELX_P35 AD8 PRO C 104 ? HIS C 125 ? PRO C 100 HIS C 121 1 ? 22 
HELX_P HELX_P36 AD9 LYS C 133 ? GLN C 135 ? LYS C 129 GLN C 131 5 ? 3  
HELX_P HELX_P37 AE1 ASP C 149 ? ALA C 153 ? ASP C 145 ALA C 149 5 ? 5  
HELX_P HELX_P38 AE2 THR C 169 ? ARG C 173 ? THR C 165 ARG C 169 5 ? 5  
HELX_P HELX_P39 AE3 ALA C 174 ? LEU C 179 ? ALA C 170 LEU C 175 1 ? 6  
HELX_P HELX_P40 AE4 THR C 186 ? ARG C 203 ? THR C 182 ARG C 199 1 ? 18 
HELX_P HELX_P41 AE5 SER C 211 ? GLY C 224 ? SER C 207 GLY C 220 1 ? 14 
HELX_P HELX_P42 AE6 ASP C 260 ? LEU C 271 ? ASP C 256 LEU C 267 1 ? 12 
HELX_P HELX_P43 AE7 SER C 280 ? HIS C 287 ? SER C 276 HIS C 283 1 ? 8  
HELX_P HELX_P44 AE8 PRO C 288 ? GLN C 291 ? PRO C 284 GLN C 287 5 ? 4  
HELX_P HELX_P45 AE9 GLY D 1   ? VAL D 5   ? GLY D 171 VAL D 175 5 ? 5  
HELX_P HELX_P46 AF1 TYR D 8   ? CYS D 23  ? TYR D 178 CYS D 193 1 ? 16 
HELX_P HELX_P47 AF2 GLY D 28  ? GLN D 33  ? GLY D 198 GLN D 203 1 ? 6  
HELX_P HELX_P48 AF3 THR D 37  ? TYR D 55  ? THR D 207 TYR D 225 1 ? 19 
HELX_P HELX_P49 AF4 GLN D 58  ? SER D 74  ? GLN D 228 SER D 244 1 ? 17 
HELX_P HELX_P50 AF5 LEU D 79  ? GLU D 99  ? LEU D 249 GLU D 269 1 ? 21 
HELX_P HELX_P51 AF6 GLU D 104 ? ILE D 111 ? GLU D 274 ILE D 281 1 ? 8  
HELX_P HELX_P52 AF7 THR D 117 ? ALA D 133 ? THR D 287 ALA D 303 1 ? 17 
HELX_P HELX_P53 AF8 THR D 140 ? PHE D 149 ? THR D 310 PHE D 319 1 ? 10 
HELX_P HELX_P54 AF9 LEU D 150 ? GLN D 152 ? LEU D 320 GLN D 322 5 ? 3  
HELX_P HELX_P55 AG1 ASN D 156 ? ILE D 172 ? ASN D 326 ILE D 342 1 ? 17 
HELX_P HELX_P56 AG2 ASP D 173 ? LEU D 178 ? ASP D 343 LEU D 348 1 ? 6  
HELX_P HELX_P57 AG3 LEU D 181 ? THR D 198 ? LEU D 351 THR D 368 1 ? 18 
HELX_P HELX_P58 AG4 PRO D 203 ? GLY D 211 ? PRO D 373 GLY D 381 1 ? 9  
HELX_P HELX_P59 AG5 LEU D 217 ? ALA D 231 ? LEU D 387 ALA D 401 1 ? 15 
HELX_P HELX_P60 AG6 PRO D 232 ? HIS D 234 ? PRO D 402 HIS D 404 5 ? 3  
HELX_P HELX_P61 AG7 GLN D 237 ? TYR D 243 ? GLN D 407 TYR D 413 1 ? 7  
HELX_P HELX_P62 AG8 LYS D 244 ? HIS D 249 ? LYS D 414 HIS D 419 5 ? 6  
HELX_P HELX_P63 AG9 GLY D 250 ? LEU D 254 ? GLY D 420 LEU D 424 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A TYR 163 C ? ? ? 1_555 A TPO 164 N ? ? A TYR 159 A TPO 160 1_555 ? ? ? ? ? ? ? 1.335 ? ? 
covale2 covale both ? A TPO 164 C ? ? ? 1_555 A HIS 165 N ? ? A TPO 160 A HIS 161 1_555 ? ? ? ? ? ? ? 1.339 ? ? 
covale3 covale both ? C TYR 163 C ? ? ? 1_555 C TPO 164 N ? ? C TYR 159 C TPO 160 1_555 ? ? ? ? ? ? ? 1.331 ? ? 
covale4 covale both ? C TPO 164 C ? ? ? 1_555 C HIS 165 N ? ? C TPO 160 C HIS 161 1_555 ? ? ? ? ? ? ? 1.336 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 TPO A 164 ? . . . . TPO A 160 ? 1_555 . . . . . . . THR 1 TPO Phosphorylation 'Named protein modification' 
2 TPO C 164 ? . . . . TPO C 160 ? 1_555 . . . . . . . THR 1 TPO Phosphorylation 'Named protein modification' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 VAL 158 A . ? VAL 154 A PRO 159 A ? PRO 155 A 1 -7.14 
2 GLN 153 B . ? GLN 323 B PRO 154 B ? PRO 324 B 1 -7.16 
3 ASP 175 B . ? ASP 345 B PRO 176 B ? PRO 346 B 1 8.03  
4 VAL 158 C . ? VAL 154 C PRO 159 C ? PRO 155 C 1 -1.84 
5 GLN 153 D . ? GLN 323 D PRO 154 D ? PRO 324 D 1 -4.03 
6 ASP 175 D . ? ASP 345 D PRO 176 D ? PRO 346 D 1 4.51  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 5 ? 
AA5 ? 3 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 8   ? GLY A 17  ? PHE A 4   GLY A 13  
AA1 2 GLY A 20  ? ASN A 27  ? GLY A 16  ASN A 23  
AA1 3 VAL A 33  ? ARG A 40  ? VAL A 29  ARG A 36  
AA1 4 LYS A 79  ? GLU A 85  ? LYS A 75  GLU A 81  
AA1 5 LEU A 70  ? HIS A 75  ? LEU A 66  HIS A 71  
AA2 1 GLN A 89  ? ASP A 90  ? GLN A 85  ASP A 86  
AA2 2 LEU A 137 ? ILE A 139 ? LEU A 133 ILE A 135 
AA2 3 ILE A 145 ? LEU A 147 ? ILE A 141 LEU A 143 
AA3 1 VAL A 127 ? LEU A 128 ? VAL A 123 LEU A 124 
AA3 2 ARG A 154 ? ALA A 155 ? ARG A 150 ALA A 151 
AA4 1 PHE C 8   ? GLU C 16  ? PHE C 4   GLU C 12  
AA4 2 VAL C 21  ? ASN C 27  ? VAL C 17  ASN C 23  
AA4 3 VAL C 33  ? ARG C 40  ? VAL C 29  ARG C 36  
AA4 4 LYS C 79  ? GLU C 85  ? LYS C 75  GLU C 81  
AA4 5 LEU C 70  ? HIS C 75  ? LEU C 66  HIS C 71  
AA5 1 GLN C 89  ? ASP C 90  ? GLN C 85  ASP C 86  
AA5 2 LEU C 137 ? ILE C 139 ? LEU C 133 ILE C 135 
AA5 3 ILE C 145 ? LEU C 147 ? ILE C 141 LEU C 143 
AA6 1 VAL C 127 ? LEU C 128 ? VAL C 123 LEU C 124 
AA6 2 ARG C 154 ? ALA C 155 ? ARG C 150 ALA C 151 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 17  ? N GLY A 13  O GLY A 20  ? O GLY A 16  
AA1 2 3 N ALA A 25  ? N ALA A 21  O VAL A 34  ? O VAL A 30  
AA1 3 4 N ALA A 35  ? N ALA A 31  O PHE A 84  ? O PHE A 80  
AA1 4 5 O VAL A 83  ? O VAL A 79  N LEU A 71  ? N LEU A 67  
AA2 1 2 N GLN A 89  ? N GLN A 85  O ILE A 139 ? O ILE A 135 
AA2 2 3 N LEU A 138 ? N LEU A 134 O LYS A 146 ? O LYS A 142 
AA3 1 2 N LEU A 128 ? N LEU A 124 O ARG A 154 ? O ARG A 150 
AA4 1 2 N GLY C 15  ? N GLY C 11  O VAL C 22  ? O VAL C 18  
AA4 2 3 N ALA C 25  ? N ALA C 21  O VAL C 34  ? O VAL C 30  
AA4 3 4 N ALA C 35  ? N ALA C 31  O PHE C 84  ? O PHE C 80  
AA4 4 5 O VAL C 83  ? O VAL C 79  N LEU C 71  ? N LEU C 67  
AA5 1 2 N GLN C 89  ? N GLN C 85  O ILE C 139 ? O ILE C 135 
AA5 2 3 N LEU C 138 ? N LEU C 134 O LYS C 146 ? O LYS C 142 
AA6 1 2 N LEU C 128 ? N LEU C 124 O ARG C 154 ? O ARG C 150 
# 
_pdbx_entry_details.entry_id                   9ESW 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 THR A 72  ? ? -76.63  -147.76 
2  1 THR A 72  ? ? -74.32  -147.76 
3  1 ASN A 74  ? ? 80.09   5.37    
4  1 ASP A 127 ? ? -160.49 43.74   
5  1 ASP A 145 ? ? 58.52   82.55   
6  1 VAL A 164 ? ? 81.67   126.40  
7  1 SER A 181 ? ? -142.13 -156.15 
8  1 VAL B 175 ? ? 35.42   64.16   
9  1 TRP B 372 ? ? -33.23  115.80  
10 1 THR C 41  ? ? -132.97 -82.53  
11 1 ASP C 127 ? ? -148.29 45.02   
12 1 ASP C 145 ? ? 48.55   71.41   
13 1 VAL C 164 ? ? 72.23   131.64  
14 1 GLN D 323 ? ? -159.09 84.39   
15 1 TRP D 372 ? ? -31.85  105.68  
16 1 ASN D 431 ? ? -105.93 71.72   
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 36  ? ? 0.073 'SIDE CHAIN' 
2 1 ARG A 122 ? ? 0.158 'SIDE CHAIN' 
3 1 ARG A 150 ? ? 0.175 'SIDE CHAIN' 
4 1 ARG A 217 ? ? 0.103 'SIDE CHAIN' 
5 1 ARG C 122 ? ? 0.272 'SIDE CHAIN' 
6 1 ARG C 217 ? ? 0.260 'SIDE CHAIN' 
7 1 ARG D 250 ? ? 0.224 'SIDE CHAIN' 
# 
loop_
_pdbx_struct_mod_residue.id 
_pdbx_struct_mod_residue.label_asym_id 
_pdbx_struct_mod_residue.label_comp_id 
_pdbx_struct_mod_residue.label_seq_id 
_pdbx_struct_mod_residue.auth_asym_id 
_pdbx_struct_mod_residue.auth_comp_id 
_pdbx_struct_mod_residue.auth_seq_id 
_pdbx_struct_mod_residue.PDB_ins_code 
_pdbx_struct_mod_residue.parent_comp_id 
_pdbx_struct_mod_residue.details 
1 A TPO 164 A TPO 160 ? THR 'modified residue' 
2 C TPO 164 C TPO 160 ? THR 'modified residue' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A HIS 295 ? A HIS 299 
2  1 Y 1 A LEU 296 ? A LEU 300 
3  1 Y 1 A ARG 297 ? A ARG 301 
4  1 Y 1 A LEU 298 ? A LEU 302 
5  1 Y 1 B HIS 433 ? B HIS 263 
6  1 Y 1 B HIS 434 ? B HIS 264 
7  1 Y 1 B HIS 435 ? B HIS 265 
8  1 Y 1 B HIS 436 ? B HIS 266 
9  1 Y 1 B HIS 437 ? B HIS 267 
10 1 Y 1 B HIS 438 ? B HIS 268 
11 1 Y 1 C GLY -3  ? C GLY 1   
12 1 Y 1 C PRO -2  ? C PRO 2   
13 1 Y 1 C GLY -1  ? C GLY 3   
14 1 Y 1 C THR 221 ? C THR 225 
15 1 Y 1 C PRO 222 ? C PRO 226 
16 1 Y 1 C ASP 223 ? C ASP 227 
17 1 Y 1 C GLU 224 ? C GLU 228 
18 1 Y 1 C VAL 225 ? C VAL 229 
19 1 Y 1 C VAL 226 ? C VAL 230 
20 1 Y 1 C TRP 227 ? C TRP 231 
21 1 Y 1 C PRO 228 ? C PRO 232 
22 1 Y 1 C GLY 229 ? C GLY 233 
23 1 Y 1 C VAL 230 ? C VAL 234 
24 1 Y 1 C THR 231 ? C THR 235 
25 1 Y 1 C SER 232 ? C SER 236 
26 1 Y 1 C MET 233 ? C MET 237 
27 1 Y 1 C PRO 234 ? C PRO 238 
28 1 Y 1 C ASP 235 ? C ASP 239 
29 1 Y 1 C TYR 236 ? C TYR 240 
30 1 Y 1 C LYS 237 ? C LYS 241 
31 1 Y 1 C PRO 238 ? C PRO 242 
32 1 Y 1 C SER 239 ? C SER 243 
33 1 Y 1 C PHE 240 ? C PHE 244 
34 1 Y 1 C PRO 241 ? C PRO 245 
35 1 Y 1 C LYS 242 ? C LYS 246 
36 1 Y 1 C TRP 243 ? C TRP 247 
37 1 Y 1 C ALA 244 ? C ALA 248 
38 1 Y 1 C ARG 245 ? C ARG 249 
39 1 Y 1 C GLN 246 ? C GLN 250 
40 1 Y 1 C ASP 247 ? C ASP 251 
41 1 Y 1 C ARG 297 ? C ARG 301 
42 1 Y 1 C LEU 298 ? C LEU 302 
43 1 Y 1 D HIS 433 ? D HIS 263 
44 1 Y 1 D HIS 434 ? D HIS 264 
45 1 Y 1 D HIS 435 ? D HIS 265 
46 1 Y 1 D HIS 436 ? D HIS 266 
47 1 Y 1 D HIS 437 ? D HIS 267 
48 1 Y 1 D HIS 438 ? D HIS 268 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
IJF C4   C  Y N 161 
IJF C5   C  Y N 162 
IJF C6   C  Y N 163 
IJF N1   N  Y N 164 
IJF C3   C  Y N 165 
IJF O1   O  N N 166 
IJF C1   C  N N 167 
IJF C2   C  Y N 168 
IJF BR1  BR N N 169 
IJF H1   H  N N 170 
IJF H2   H  N N 171 
IJF H3   H  N N 172 
IJF H4   H  N N 173 
IJF H5   H  N N 174 
IJF H6   H  N N 175 
ILE N    N  N N 176 
ILE CA   C  N S 177 
ILE C    C  N N 178 
ILE O    O  N N 179 
ILE CB   C  N S 180 
ILE CG1  C  N N 181 
ILE CG2  C  N N 182 
ILE CD1  C  N N 183 
ILE OXT  O  N N 184 
ILE H    H  N N 185 
ILE H2   H  N N 186 
ILE HA   H  N N 187 
ILE HB   H  N N 188 
ILE HG12 H  N N 189 
ILE HG13 H  N N 190 
ILE HG21 H  N N 191 
ILE HG22 H  N N 192 
ILE HG23 H  N N 193 
ILE HD11 H  N N 194 
ILE HD12 H  N N 195 
ILE HD13 H  N N 196 
ILE HXT  H  N N 197 
LEU N    N  N N 198 
LEU CA   C  N S 199 
LEU C    C  N N 200 
LEU O    O  N N 201 
LEU CB   C  N N 202 
LEU CG   C  N N 203 
LEU CD1  C  N N 204 
LEU CD2  C  N N 205 
LEU OXT  O  N N 206 
LEU H    H  N N 207 
LEU H2   H  N N 208 
LEU HA   H  N N 209 
LEU HB2  H  N N 210 
LEU HB3  H  N N 211 
LEU HG   H  N N 212 
LEU HD11 H  N N 213 
LEU HD12 H  N N 214 
LEU HD13 H  N N 215 
LEU HD21 H  N N 216 
LEU HD22 H  N N 217 
LEU HD23 H  N N 218 
LEU HXT  H  N N 219 
LYS N    N  N N 220 
LYS CA   C  N S 221 
LYS C    C  N N 222 
LYS O    O  N N 223 
LYS CB   C  N N 224 
LYS CG   C  N N 225 
LYS CD   C  N N 226 
LYS CE   C  N N 227 
LYS NZ   N  N N 228 
LYS OXT  O  N N 229 
LYS H    H  N N 230 
LYS H2   H  N N 231 
LYS HA   H  N N 232 
LYS HB2  H  N N 233 
LYS HB3  H  N N 234 
LYS HG2  H  N N 235 
LYS HG3  H  N N 236 
LYS HD2  H  N N 237 
LYS HD3  H  N N 238 
LYS HE2  H  N N 239 
LYS HE3  H  N N 240 
LYS HZ1  H  N N 241 
LYS HZ2  H  N N 242 
LYS HZ3  H  N N 243 
LYS HXT  H  N N 244 
MET N    N  N N 245 
MET CA   C  N S 246 
MET C    C  N N 247 
MET O    O  N N 248 
MET CB   C  N N 249 
MET CG   C  N N 250 
MET SD   S  N N 251 
MET CE   C  N N 252 
MET OXT  O  N N 253 
MET H    H  N N 254 
MET H2   H  N N 255 
MET HA   H  N N 256 
MET HB2  H  N N 257 
MET HB3  H  N N 258 
MET HG2  H  N N 259 
MET HG3  H  N N 260 
MET HE1  H  N N 261 
MET HE2  H  N N 262 
MET HE3  H  N N 263 
MET HXT  H  N N 264 
PHE N    N  N N 265 
PHE CA   C  N S 266 
PHE C    C  N N 267 
PHE O    O  N N 268 
PHE CB   C  N N 269 
PHE CG   C  Y N 270 
PHE CD1  C  Y N 271 
PHE CD2  C  Y N 272 
PHE CE1  C  Y N 273 
PHE CE2  C  Y N 274 
PHE CZ   C  Y N 275 
PHE OXT  O  N N 276 
PHE H    H  N N 277 
PHE H2   H  N N 278 
PHE HA   H  N N 279 
PHE HB2  H  N N 280 
PHE HB3  H  N N 281 
PHE HD1  H  N N 282 
PHE HD2  H  N N 283 
PHE HE1  H  N N 284 
PHE HE2  H  N N 285 
PHE HZ   H  N N 286 
PHE HXT  H  N N 287 
PRO N    N  N N 288 
PRO CA   C  N S 289 
PRO C    C  N N 290 
PRO O    O  N N 291 
PRO CB   C  N N 292 
PRO CG   C  N N 293 
PRO CD   C  N N 294 
PRO OXT  O  N N 295 
PRO H    H  N N 296 
PRO HA   H  N N 297 
PRO HB2  H  N N 298 
PRO HB3  H  N N 299 
PRO HG2  H  N N 300 
PRO HG3  H  N N 301 
PRO HD2  H  N N 302 
PRO HD3  H  N N 303 
PRO HXT  H  N N 304 
SER N    N  N N 305 
SER CA   C  N S 306 
SER C    C  N N 307 
SER O    O  N N 308 
SER CB   C  N N 309 
SER OG   O  N N 310 
SER OXT  O  N N 311 
SER H    H  N N 312 
SER H2   H  N N 313 
SER HA   H  N N 314 
SER HB2  H  N N 315 
SER HB3  H  N N 316 
SER HG   H  N N 317 
SER HXT  H  N N 318 
THR N    N  N N 319 
THR CA   C  N S 320 
THR C    C  N N 321 
THR O    O  N N 322 
THR CB   C  N R 323 
THR OG1  O  N N 324 
THR CG2  C  N N 325 
THR OXT  O  N N 326 
THR H    H  N N 327 
THR H2   H  N N 328 
THR HA   H  N N 329 
THR HB   H  N N 330 
THR HG1  H  N N 331 
THR HG21 H  N N 332 
THR HG22 H  N N 333 
THR HG23 H  N N 334 
THR HXT  H  N N 335 
TPO N    N  N N 336 
TPO CA   C  N S 337 
TPO CB   C  N R 338 
TPO CG2  C  N N 339 
TPO OG1  O  N N 340 
TPO P    P  N N 341 
TPO O1P  O  N N 342 
TPO O2P  O  N N 343 
TPO O3P  O  N N 344 
TPO C    C  N N 345 
TPO O    O  N N 346 
TPO OXT  O  N N 347 
TPO H    H  N N 348 
TPO H2   H  N N 349 
TPO HA   H  N N 350 
TPO HB   H  N N 351 
TPO HG21 H  N N 352 
TPO HG22 H  N N 353 
TPO HG23 H  N N 354 
TPO HOP2 H  N N 355 
TPO HOP3 H  N N 356 
TPO HXT  H  N N 357 
TRP N    N  N N 358 
TRP CA   C  N S 359 
TRP C    C  N N 360 
TRP O    O  N N 361 
TRP CB   C  N N 362 
TRP CG   C  Y N 363 
TRP CD1  C  Y N 364 
TRP CD2  C  Y N 365 
TRP NE1  N  Y N 366 
TRP CE2  C  Y N 367 
TRP CE3  C  Y N 368 
TRP CZ2  C  Y N 369 
TRP CZ3  C  Y N 370 
TRP CH2  C  Y N 371 
TRP OXT  O  N N 372 
TRP H    H  N N 373 
TRP H2   H  N N 374 
TRP HA   H  N N 375 
TRP HB2  H  N N 376 
TRP HB3  H  N N 377 
TRP HD1  H  N N 378 
TRP HE1  H  N N 379 
TRP HE3  H  N N 380 
TRP HZ2  H  N N 381 
TRP HZ3  H  N N 382 
TRP HH2  H  N N 383 
TRP HXT  H  N N 384 
TYR N    N  N N 385 
TYR CA   C  N S 386 
TYR C    C  N N 387 
TYR O    O  N N 388 
TYR CB   C  N N 389 
TYR CG   C  Y N 390 
TYR CD1  C  Y N 391 
TYR CD2  C  Y N 392 
TYR CE1  C  Y N 393 
TYR CE2  C  Y N 394 
TYR CZ   C  Y N 395 
TYR OH   O  N N 396 
TYR OXT  O  N N 397 
TYR H    H  N N 398 
TYR H2   H  N N 399 
TYR HA   H  N N 400 
TYR HB2  H  N N 401 
TYR HB3  H  N N 402 
TYR HD1  H  N N 403 
TYR HD2  H  N N 404 
TYR HE1  H  N N 405 
TYR HE2  H  N N 406 
TYR HH   H  N N 407 
TYR HXT  H  N N 408 
VAL N    N  N N 409 
VAL CA   C  N S 410 
VAL C    C  N N 411 
VAL O    O  N N 412 
VAL CB   C  N N 413 
VAL CG1  C  N N 414 
VAL CG2  C  N N 415 
VAL OXT  O  N N 416 
VAL H    H  N N 417 
VAL H2   H  N N 418 
VAL HA   H  N N 419 
VAL HB   H  N N 420 
VAL HG11 H  N N 421 
VAL HG12 H  N N 422 
VAL HG13 H  N N 423 
VAL HG21 H  N N 424 
VAL HG22 H  N N 425 
VAL HG23 H  N N 426 
VAL HXT  H  N N 427 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
IJF C5  C6   doub Y N 152 
IJF C5  C4   sing Y N 153 
IJF C6  N1   sing Y N 154 
IJF BR1 C4   sing N N 155 
IJF C4  C3   doub Y N 156 
IJF N1  C2   doub Y N 157 
IJF C2  C3   sing Y N 158 
IJF C2  C1   sing N N 159 
IJF C1  O1   sing N N 160 
IJF C5  H1   sing N N 161 
IJF C6  H2   sing N N 162 
IJF C3  H3   sing N N 163 
IJF O1  H4   sing N N 164 
IJF C1  H5   sing N N 165 
IJF C1  H6   sing N N 166 
ILE N   CA   sing N N 167 
ILE N   H    sing N N 168 
ILE N   H2   sing N N 169 
ILE CA  C    sing N N 170 
ILE CA  CB   sing N N 171 
ILE CA  HA   sing N N 172 
ILE C   O    doub N N 173 
ILE C   OXT  sing N N 174 
ILE CB  CG1  sing N N 175 
ILE CB  CG2  sing N N 176 
ILE CB  HB   sing N N 177 
ILE CG1 CD1  sing N N 178 
ILE CG1 HG12 sing N N 179 
ILE CG1 HG13 sing N N 180 
ILE CG2 HG21 sing N N 181 
ILE CG2 HG22 sing N N 182 
ILE CG2 HG23 sing N N 183 
ILE CD1 HD11 sing N N 184 
ILE CD1 HD12 sing N N 185 
ILE CD1 HD13 sing N N 186 
ILE OXT HXT  sing N N 187 
LEU N   CA   sing N N 188 
LEU N   H    sing N N 189 
LEU N   H2   sing N N 190 
LEU CA  C    sing N N 191 
LEU CA  CB   sing N N 192 
LEU CA  HA   sing N N 193 
LEU C   O    doub N N 194 
LEU C   OXT  sing N N 195 
LEU CB  CG   sing N N 196 
LEU CB  HB2  sing N N 197 
LEU CB  HB3  sing N N 198 
LEU CG  CD1  sing N N 199 
LEU CG  CD2  sing N N 200 
LEU CG  HG   sing N N 201 
LEU CD1 HD11 sing N N 202 
LEU CD1 HD12 sing N N 203 
LEU CD1 HD13 sing N N 204 
LEU CD2 HD21 sing N N 205 
LEU CD2 HD22 sing N N 206 
LEU CD2 HD23 sing N N 207 
LEU OXT HXT  sing N N 208 
LYS N   CA   sing N N 209 
LYS N   H    sing N N 210 
LYS N   H2   sing N N 211 
LYS CA  C    sing N N 212 
LYS CA  CB   sing N N 213 
LYS CA  HA   sing N N 214 
LYS C   O    doub N N 215 
LYS C   OXT  sing N N 216 
LYS CB  CG   sing N N 217 
LYS CB  HB2  sing N N 218 
LYS CB  HB3  sing N N 219 
LYS CG  CD   sing N N 220 
LYS CG  HG2  sing N N 221 
LYS CG  HG3  sing N N 222 
LYS CD  CE   sing N N 223 
LYS CD  HD2  sing N N 224 
LYS CD  HD3  sing N N 225 
LYS CE  NZ   sing N N 226 
LYS CE  HE2  sing N N 227 
LYS CE  HE3  sing N N 228 
LYS NZ  HZ1  sing N N 229 
LYS NZ  HZ2  sing N N 230 
LYS NZ  HZ3  sing N N 231 
LYS OXT HXT  sing N N 232 
MET N   CA   sing N N 233 
MET N   H    sing N N 234 
MET N   H2   sing N N 235 
MET CA  C    sing N N 236 
MET CA  CB   sing N N 237 
MET CA  HA   sing N N 238 
MET C   O    doub N N 239 
MET C   OXT  sing N N 240 
MET CB  CG   sing N N 241 
MET CB  HB2  sing N N 242 
MET CB  HB3  sing N N 243 
MET CG  SD   sing N N 244 
MET CG  HG2  sing N N 245 
MET CG  HG3  sing N N 246 
MET SD  CE   sing N N 247 
MET CE  HE1  sing N N 248 
MET CE  HE2  sing N N 249 
MET CE  HE3  sing N N 250 
MET OXT HXT  sing N N 251 
PHE N   CA   sing N N 252 
PHE N   H    sing N N 253 
PHE N   H2   sing N N 254 
PHE CA  C    sing N N 255 
PHE CA  CB   sing N N 256 
PHE CA  HA   sing N N 257 
PHE C   O    doub N N 258 
PHE C   OXT  sing N N 259 
PHE CB  CG   sing N N 260 
PHE CB  HB2  sing N N 261 
PHE CB  HB3  sing N N 262 
PHE CG  CD1  doub Y N 263 
PHE CG  CD2  sing Y N 264 
PHE CD1 CE1  sing Y N 265 
PHE CD1 HD1  sing N N 266 
PHE CD2 CE2  doub Y N 267 
PHE CD2 HD2  sing N N 268 
PHE CE1 CZ   doub Y N 269 
PHE CE1 HE1  sing N N 270 
PHE CE2 CZ   sing Y N 271 
PHE CE2 HE2  sing N N 272 
PHE CZ  HZ   sing N N 273 
PHE OXT HXT  sing N N 274 
PRO N   CA   sing N N 275 
PRO N   CD   sing N N 276 
PRO N   H    sing N N 277 
PRO CA  C    sing N N 278 
PRO CA  CB   sing N N 279 
PRO CA  HA   sing N N 280 
PRO C   O    doub N N 281 
PRO C   OXT  sing N N 282 
PRO CB  CG   sing N N 283 
PRO CB  HB2  sing N N 284 
PRO CB  HB3  sing N N 285 
PRO CG  CD   sing N N 286 
PRO CG  HG2  sing N N 287 
PRO CG  HG3  sing N N 288 
PRO CD  HD2  sing N N 289 
PRO CD  HD3  sing N N 290 
PRO OXT HXT  sing N N 291 
SER N   CA   sing N N 292 
SER N   H    sing N N 293 
SER N   H2   sing N N 294 
SER CA  C    sing N N 295 
SER CA  CB   sing N N 296 
SER CA  HA   sing N N 297 
SER C   O    doub N N 298 
SER C   OXT  sing N N 299 
SER CB  OG   sing N N 300 
SER CB  HB2  sing N N 301 
SER CB  HB3  sing N N 302 
SER OG  HG   sing N N 303 
SER OXT HXT  sing N N 304 
THR N   CA   sing N N 305 
THR N   H    sing N N 306 
THR N   H2   sing N N 307 
THR CA  C    sing N N 308 
THR CA  CB   sing N N 309 
THR CA  HA   sing N N 310 
THR C   O    doub N N 311 
THR C   OXT  sing N N 312 
THR CB  OG1  sing N N 313 
THR CB  CG2  sing N N 314 
THR CB  HB   sing N N 315 
THR OG1 HG1  sing N N 316 
THR CG2 HG21 sing N N 317 
THR CG2 HG22 sing N N 318 
THR CG2 HG23 sing N N 319 
THR OXT HXT  sing N N 320 
TPO N   CA   sing N N 321 
TPO N   H    sing N N 322 
TPO N   H2   sing N N 323 
TPO CA  CB   sing N N 324 
TPO CA  C    sing N N 325 
TPO CA  HA   sing N N 326 
TPO CB  CG2  sing N N 327 
TPO CB  OG1  sing N N 328 
TPO CB  HB   sing N N 329 
TPO CG2 HG21 sing N N 330 
TPO CG2 HG22 sing N N 331 
TPO CG2 HG23 sing N N 332 
TPO OG1 P    sing N N 333 
TPO P   O1P  doub N N 334 
TPO P   O2P  sing N N 335 
TPO P   O3P  sing N N 336 
TPO O2P HOP2 sing N N 337 
TPO O3P HOP3 sing N N 338 
TPO C   O    doub N N 339 
TPO C   OXT  sing N N 340 
TPO OXT HXT  sing N N 341 
TRP N   CA   sing N N 342 
TRP N   H    sing N N 343 
TRP N   H2   sing N N 344 
TRP CA  C    sing N N 345 
TRP CA  CB   sing N N 346 
TRP CA  HA   sing N N 347 
TRP C   O    doub N N 348 
TRP C   OXT  sing N N 349 
TRP CB  CG   sing N N 350 
TRP CB  HB2  sing N N 351 
TRP CB  HB3  sing N N 352 
TRP CG  CD1  doub Y N 353 
TRP CG  CD2  sing Y N 354 
TRP CD1 NE1  sing Y N 355 
TRP CD1 HD1  sing N N 356 
TRP CD2 CE2  doub Y N 357 
TRP CD2 CE3  sing Y N 358 
TRP NE1 CE2  sing Y N 359 
TRP NE1 HE1  sing N N 360 
TRP CE2 CZ2  sing Y N 361 
TRP CE3 CZ3  doub Y N 362 
TRP CE3 HE3  sing N N 363 
TRP CZ2 CH2  doub Y N 364 
TRP CZ2 HZ2  sing N N 365 
TRP CZ3 CH2  sing Y N 366 
TRP CZ3 HZ3  sing N N 367 
TRP CH2 HH2  sing N N 368 
TRP OXT HXT  sing N N 369 
TYR N   CA   sing N N 370 
TYR N   H    sing N N 371 
TYR N   H2   sing N N 372 
TYR CA  C    sing N N 373 
TYR CA  CB   sing N N 374 
TYR CA  HA   sing N N 375 
TYR C   O    doub N N 376 
TYR C   OXT  sing N N 377 
TYR CB  CG   sing N N 378 
TYR CB  HB2  sing N N 379 
TYR CB  HB3  sing N N 380 
TYR CG  CD1  doub Y N 381 
TYR CG  CD2  sing Y N 382 
TYR CD1 CE1  sing Y N 383 
TYR CD1 HD1  sing N N 384 
TYR CD2 CE2  doub Y N 385 
TYR CD2 HD2  sing N N 386 
TYR CE1 CZ   doub Y N 387 
TYR CE1 HE1  sing N N 388 
TYR CE2 CZ   sing Y N 389 
TYR CE2 HE2  sing N N 390 
TYR CZ  OH   sing N N 391 
TYR OH  HH   sing N N 392 
TYR OXT HXT  sing N N 393 
VAL N   CA   sing N N 394 
VAL N   H    sing N N 395 
VAL N   H2   sing N N 396 
VAL CA  C    sing N N 397 
VAL CA  CB   sing N N 398 
VAL CA  HA   sing N N 399 
VAL C   O    doub N N 400 
VAL C   OXT  sing N N 401 
VAL CB  CG1  sing N N 402 
VAL CB  CG2  sing N N 403 
VAL CB  HB   sing N N 404 
VAL CG1 HG11 sing N N 405 
VAL CG1 HG12 sing N N 406 
VAL CG1 HG13 sing N N 407 
VAL CG2 HG21 sing N N 408 
VAL CG2 HG22 sing N N 409 
VAL CG2 HG23 sing N N 410 
VAL OXT HXT  sing N N 411 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Medical Research Council (MRC, United Kingdom)' 'United Kingdom' MR/N009738/1 1 
'Medical Research Council (MRC, United Kingdom)' 'United Kingdom' MR/V029142/1 2 
'Cancer Research UK'                             'United Kingdom' C2115/A21421 3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6GUC 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9ESW 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013491 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007461 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006762 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
BR 35 35 17.1822 2.1723  5.2368 16.5796 5.6388 0.2609  3.9859 41.4328 -0.0527  
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
P  15 15 6.4348  1.9067  4.1793 27.1570 1.7801 0.5260  1.4909 68.1645 1.2466   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0257   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLY A 1 1   ? -19.741 -6.19   25.786  1    61.2   ? -3  GLY A N   1 
ATOM   2    C  CA  . GLY A 1 1   ? -21.218 -6.109  25.812  1    79.34  ? -3  GLY A CA  1 
ATOM   3    C  C   . GLY A 1 1   ? -21.791 -6.797  27.053  1    104.2  ? -3  GLY A C   1 
ATOM   4    O  O   . GLY A 1 1   ? -21.833 -6.195  28.128  1    116.77 ? -3  GLY A O   1 
ATOM   5    N  N   . PRO A 1 2   ? -22.263 -8.068  26.949  1    114.19 ? -2  PRO A N   1 
ATOM   6    C  CA  . PRO A 1 2   ? -22.723 -8.831  28.12   1    115.15 ? -2  PRO A CA  1 
ATOM   7    C  C   . PRO A 1 2   ? -21.65  -9.308  29.108  1    107.39 ? -2  PRO A C   1 
ATOM   8    O  O   . PRO A 1 2   ? -21.563 -10.509 29.38   1    92.73  ? -2  PRO A O   1 
ATOM   9    C  CB  . PRO A 1 2   ? -23.516 -10.035 27.523  1    104.88 ? -2  PRO A CB  1 
ATOM   10   C  CG  . PRO A 1 2   ? -23.437 -9.902  26.012  1    101.93 ? -2  PRO A CG  1 
ATOM   11   C  CD  . PRO A 1 2   ? -22.414 -8.824  25.694  1    108.45 ? -2  PRO A CD  1 
ATOM   12   N  N   . GLY A 1 3   ? -20.844 -8.378  29.654  1    90.63  ? -1  GLY A N   1 
ATOM   13   C  CA  . GLY A 1 3   ? -19.72  -8.773  30.496  1    82.77  ? -1  GLY A CA  1 
ATOM   14   C  C   . GLY A 1 3   ? -18.638 -7.701  30.638  1    75.77  ? -1  GLY A C   1 
ATOM   15   O  O   . GLY A 1 3   ? -18.487 -6.826  29.789  1    63.61  ? -1  GLY A O   1 
ATOM   16   N  N   . SER A 1 4   ? -17.91  -7.798  31.757  1    84.45  ? 0   SER A N   1 
ATOM   17   C  CA  . SER A 1 4   ? -16.843 -6.908  32.196  1    77.06  ? 0   SER A CA  1 
ATOM   18   C  C   . SER A 1 4   ? -15.797 -7.762  32.926  1    68.14  ? 0   SER A C   1 
ATOM   19   O  O   . SER A 1 4   ? -16.147 -8.829  33.433  1    69.45  ? 0   SER A O   1 
ATOM   20   C  CB  . SER A 1 4   ? -17.431 -5.817  33.087  1    77.08  ? 0   SER A CB  1 
ATOM   21   O  OG  . SER A 1 4   ? -16.442 -5.006  33.713  1    78.47  ? 0   SER A OG  1 
ATOM   22   N  N   . MET A 1 5   ? -14.532 -7.309  33.003  1    54.37  ? 1   MET A N   1 
ATOM   23   C  CA  . MET A 1 5   ? -13.461 -8.133  33.567  1    41.19  ? 1   MET A CA  1 
ATOM   24   C  C   . MET A 1 5   ? -13.569 -8.251  35.084  1    37.21  ? 1   MET A C   1 
ATOM   25   O  O   . MET A 1 5   ? -12.833 -9.028  35.683  1    41.97  ? 1   MET A O   1 
ATOM   26   C  CB  . MET A 1 5   ? -12.048 -7.633  33.239  1    36.92  ? 1   MET A CB  1 
ATOM   27   C  CG  . MET A 1 5   ? -11.821 -7.432  31.769  1    31.28  ? 1   MET A CG  1 
ATOM   28   S  SD  . MET A 1 5   ? -12.466 -8.821  30.831  1    34.14  ? 1   MET A SD  1 
ATOM   29   C  CE  . MET A 1 5   ? -11.128 -9.987  31.079  1    30.36  ? 1   MET A CE  1 
ATOM   30   N  N   . GLU A 1 6   ? -14.466 -7.474  35.692  1    39.45  ? 2   GLU A N   1 
ATOM   31   C  CA  . GLU A 1 6   ? -14.781 -7.594  37.108  1    41.42  ? 2   GLU A CA  1 
ATOM   32   C  C   . GLU A 1 6   ? -15.211 -9.029  37.419  1    35.13  ? 2   GLU A C   1 
ATOM   33   O  O   . GLU A 1 6   ? -14.83  -9.542  38.458  1    32.99  ? 2   GLU A O   1 
ATOM   34   C  CB  . GLU A 1 6   ? -15.776 -6.497  37.508  1    56.45  ? 2   GLU A CB  1 
ATOM   35   C  CG  . GLU A 1 6   ? -16.652 -6.799  38.727  1    73.49  ? 2   GLU A CG  1 
ATOM   36   C  CD  . GLU A 1 6   ? -18.091 -6.264  38.661  1    79.56  ? 2   GLU A CD  1 
ATOM   37   O  OE1 . GLU A 1 6   ? -18.898 -6.694  39.519  1    69.42  ? 2   GLU A OE1 1 
ATOM   38   O  OE2 . GLU A 1 6   ? -18.433 -5.427  37.777  1    73.42  ? 2   GLU A OE2 1 
ATOM   39   N  N   . ASN A 1 7   ? -15.95  -9.684  36.502  1    32.14  ? 3   ASN A N   1 
ATOM   40   C  CA  . ASN A 1 7   ? -16.568 -10.971 36.788  1    30.48  ? 3   ASN A CA  1 
ATOM   41   C  C   . ASN A 1 7   ? -15.698 -12.158 36.385  1    31.17  ? 3   ASN A C   1 
ATOM   42   O  O   . ASN A 1 7   ? -16.144 -13.291 36.536  1    34.77  ? 3   ASN A O   1 
ATOM   43   C  CB  . ASN A 1 7   ? -17.901 -11.193 36.085  1    31.56  ? 3   ASN A CB  1 
ATOM   44   C  CG  . ASN A 1 7   ? -18.929 -10.124 36.356  1    39.65  ? 3   ASN A CG  1 
ATOM   45   O  OD1 . ASN A 1 7   ? -19.013 -9.556  37.466  1    38.95  ? 3   ASN A OD1 1 
ATOM   46   N  ND2 . ASN A 1 7   ? -19.729 -9.863  35.326  1    44.57  ? 3   ASN A ND2 1 
ATOM   47   N  N   . PHE A 1 8   ? -14.493 -11.924 35.846  1    28.39  ? 4   PHE A N   1 
ATOM   48   C  CA  . PHE A 1 8   ? -13.601 -13.031 35.53   1    25     ? 4   PHE A CA  1 
ATOM   49   C  C   . PHE A 1 8   ? -12.479 -13.161 36.571  1    27.86  ? 4   PHE A C   1 
ATOM   50   O  O   . PHE A 1 8   ? -11.942 -12.18  37.092  1    26.79  ? 4   PHE A O   1 
ATOM   51   C  CB  . PHE A 1 8   ? -13.09  -12.912 34.107  1    22.16  ? 4   PHE A CB  1 
ATOM   52   C  CG  . PHE A 1 8   ? -14.183 -13.026 33.067  1    24.45  ? 4   PHE A CG  1 
ATOM   53   C  CD1 . PHE A 1 8   ? -14.714 -14.265 32.729  1    24.61  ? 4   PHE A CD1 1 
ATOM   54   C  CD2 . PHE A 1 8   ? -14.674 -11.895 32.409  1    27.41  ? 4   PHE A CD2 1 
ATOM   55   C  CE1 . PHE A 1 8   ? -15.722 -14.376 31.765  1    25.81  ? 4   PHE A CE1 1 
ATOM   56   C  CE2 . PHE A 1 8   ? -15.694 -12.013 31.457  1    27.97  ? 4   PHE A CE2 1 
ATOM   57   C  CZ  . PHE A 1 8   ? -16.209 -13.254 31.115  1    24.6   ? 4   PHE A CZ  1 
ATOM   58   N  N   . GLN A 1 9   ? -12.162 -14.421 36.883  1    28.86  ? 5   GLN A N   1 
ATOM   59   C  CA  . GLN A 1 9   ? -11.063 -14.801 37.75   1    25.92  ? 5   GLN A CA  1 
ATOM   60   C  C   . GLN A 1 9   ? -10.09  -15.6   36.893  1    24.89  ? 5   GLN A C   1 
ATOM   61   O  O   . GLN A 1 9   ? -10.443 -16.673 36.41   1    24.05  ? 5   GLN A O   1 
ATOM   62   C  CB  . GLN A 1 9   ? -11.625 -15.612 38.918  1    27.29  ? 5   GLN A CB  1 
ATOM   63   C  CG  . GLN A 1 9   ? -10.578 -16.146 39.891  1    31.68  ? 5   GLN A CG  1 
ATOM   64   C  CD  . GLN A 1 9   ? -9.757  -15.045 40.531  1    39.09  ? 5   GLN A CD  1 
ATOM   65   O  OE1 . GLN A 1 9   ? -10.271 -14.169 41.245  1    44.03  ? 5   GLN A OE1 1 
ATOM   66   N  NE2 . GLN A 1 9   ? -8.462  -15.06  40.252  1    37.38  ? 5   GLN A NE2 1 
ATOM   67   N  N   . LYS A 1 10  ? -8.896  -15.034 36.664  1    24.32  ? 6   LYS A N   1 
ATOM   68   C  CA  . LYS A 1 10  ? -7.842  -15.717 35.935  1    26.55  ? 6   LYS A CA  1 
ATOM   69   C  C   . LYS A 1 10  ? -7.44   -16.987 36.671  1    25.19  ? 6   LYS A C   1 
ATOM   70   O  O   . LYS A 1 10  ? -7.481  -17.02  37.89   1    22.92  ? 6   LYS A O   1 
ATOM   71   C  CB  . LYS A 1 10  ? -6.631  -14.802 35.763  1    33.73  ? 6   LYS A CB  1 
ATOM   72   C  CG  . LYS A 1 10  ? -6.43   -14.294 34.333  1    49.4   ? 6   LYS A CG  1 
ATOM   73   C  CD  . LYS A 1 10  ? -5.405  -13.162 34.267  1    61.43  ? 6   LYS A CD  1 
ATOM   74   C  CE  . LYS A 1 10  ? -4.159  -13.349 35.113  1    59.82  ? 6   LYS A CE  1 
ATOM   75   N  NZ  . LYS A 1 10  ? -3.05   -12.565 34.568  1    55.25  ? 6   LYS A NZ  1 
ATOM   76   N  N   . VAL A 1 11  ? -7.08   -18.024 35.91   1    29.23  ? 7   VAL A N   1 
ATOM   77   C  CA  . VAL A 1 11  ? -6.777  -19.321 36.497  1    32.59  ? 7   VAL A CA  1 
ATOM   78   C  C   . VAL A 1 11  ? -5.336  -19.709 36.169  1    32.83  ? 7   VAL A C   1 
ATOM   79   O  O   . VAL A 1 11  ? -4.574  -19.986 37.083  1    45.68  ? 7   VAL A O   1 
ATOM   80   C  CB  . VAL A 1 11  ? -7.795  -20.401 36.082  1    33.01  ? 7   VAL A CB  1 
ATOM   81   C  CG1 . VAL A 1 11  ? -7.363  -21.793 36.5    1    33.32  ? 7   VAL A CG1 1 
ATOM   82   C  CG2 . VAL A 1 11  ? -9.173  -20.103 36.64   1    30.54  ? 7   VAL A CG2 1 
ATOM   83   N  N   . GLU A 1 12  ? -4.972  -19.7   34.881  1    31.26  ? 8   GLU A N   1 
ATOM   84   C  CA  . GLU A 1 12  ? -3.606  -19.955 34.467  1    32.77  ? 8   GLU A CA  1 
ATOM   85   C  C   . GLU A 1 12  ? -3.443  -19.583 33.001  1    37.26  ? 8   GLU A C   1 
ATOM   86   O  O   . GLU A 1 12  ? -4.43   -19.547 32.267  1    41.76  ? 8   GLU A O   1 
ATOM   87   C  CB  . GLU A 1 12  ? -3.281  -21.435 34.637  1    33.82  ? 8   GLU A CB  1 
ATOM   88   C  CG  . GLU A 1 12  ? -4.031  -22.351 33.678  1    35.72  ? 8   GLU A CG  1 
ATOM   89   C  CD  . GLU A 1 12  ? -3.813  -23.832 33.899  1    39.77  ? 8   GLU A CD  1 
ATOM   90   O  OE1 . GLU A 1 12  ? -3.356  -24.232 34.983  1    44.85  ? 8   GLU A OE1 1 
ATOM   91   O  OE2 . GLU A 1 12  ? -4.085  -24.594 32.961  1    48.28  ? 8   GLU A OE2 1 
ATOM   92   N  N   . LYS A 1 13  ? -2.199  -19.272 32.592  1    35.4   ? 9   LYS A N   1 
ATOM   93   C  CA  . LYS A 1 13  ? -1.896  -19.052 31.188  1    33.69  ? 9   LYS A CA  1 
ATOM   94   C  C   . LYS A 1 13  ? -2.166  -20.369 30.471  1    32.8   ? 9   LYS A C   1 
ATOM   95   O  O   . LYS A 1 13  ? -1.958  -21.429 31.058  1    34.4   ? 9   LYS A O   1 
ATOM   96   C  CB  . LYS A 1 13  ? -0.44   -18.596 31.073  1    39.96  ? 9   LYS A CB  1 
ATOM   97   C  CG  . LYS A 1 13  ? -0.027  -18.13  29.682  1    50.57  ? 9   LYS A CG  1 
ATOM   98   C  CD  . LYS A 1 13  ? 1.48    -18.07  29.419  1    59.62  ? 9   LYS A CD  1 
ATOM   99   C  CE  . LYS A 1 13  ? 1.799   -17.587 28.025  1    67.03  ? 9   LYS A CE  1 
ATOM   100  N  NZ  . LYS A 1 13  ? 3.106   -18.058 27.541  1    71.63  ? 9   LYS A NZ  1 
ATOM   101  N  N   . ILE A 1 14  ? -2.668  -20.323 29.232  1    30.32  ? 10  ILE A N   1 
ATOM   102  C  CA  . ILE A 1 14  ? -2.842  -21.568 28.504  1    31.59  ? 10  ILE A CA  1 
ATOM   103  C  C   . ILE A 1 14  ? -2.189  -21.532 27.135  1    36.54  ? 10  ILE A C   1 
ATOM   104  O  O   . ILE A 1 14  ? -2.274  -22.531 26.411  1    48.4   ? 10  ILE A O   1 
ATOM   105  C  CB  . ILE A 1 14  ? -4.31   -22.013 28.389  1    35.72  ? 10  ILE A CB  1 
ATOM   106  C  CG1 . ILE A 1 14  ? -5.194  -20.967 27.696  1    35.64  ? 10  ILE A CG1 1 
ATOM   107  C  CG2 . ILE A 1 14  ? -4.853  -22.441 29.753  1    38.01  ? 10  ILE A CG2 1 
ATOM   108  C  CD1 . ILE A 1 14  ? -6.671  -21.307 27.653  1    31.53  ? 10  ILE A CD1 1 
ATOM   109  N  N   . GLY A 1 15  ? -1.574  -20.404 26.765  1    39.79  ? 11  GLY A N   1 
ATOM   110  C  CA  . GLY A 1 15  ? -1.051  -20.307 25.403  1    47.91  ? 11  GLY A CA  1 
ATOM   111  C  C   . GLY A 1 15  ? -0.638  -18.896 24.993  1    49.32  ? 11  GLY A C   1 
ATOM   112  O  O   . GLY A 1 15  ? -0.677  -17.947 25.784  1    48.41  ? 11  GLY A O   1 
ATOM   113  N  N   . GLU A 1 16  ? -0.195  -18.788 23.748  1    52.84  ? 12  GLU A N   1 
ATOM   114  C  CA  . GLU A 1 16  ? 0.258   -17.474 23.243  1    63.71  ? 12  GLU A CA  1 
ATOM   115  C  C   . GLU A 1 16  ? -0.107  -17.367 21.764  1    72.93  ? 12  GLU A C   1 
ATOM   116  O  O   . GLU A 1 16  ? 0.027   -18.373 21.044  1    72.76  ? 12  GLU A O   1 
ATOM   117  C  CB  . GLU A 1 16  ? 1.762   -17.311 23.436  1    61.29  ? 12  GLU A CB  1 
ATOM   118  C  CG  . GLU A 1 16  ? 2.115   -16.226 24.448  1    69.61  ? 12  GLU A CG  1 
ATOM   119  C  CD  . GLU A 1 16  ? 3.534   -15.716 24.302  1    72.23  ? 12  GLU A CD  1 
ATOM   120  O  OE1 . GLU A 1 16  ? 3.891   -14.755 25.013  1    83.61  ? 12  GLU A OE1 1 
ATOM   121  O  OE2 . GLU A 1 16  ? 4.28    -16.28  23.475  1    68.63  ? 12  GLU A OE2 1 
ATOM   122  N  N   . GLY A 1 17  ? -0.567  -16.192 21.349  1    84.38  ? 13  GLY A N   1 
ATOM   123  C  CA  . GLY A 1 17  ? -0.901  -15.973 19.937  1    90.32  ? 13  GLY A CA  1 
ATOM   124  C  C   . GLY A 1 17  ? -0.042  -14.871 19.365  1    100.3  ? 13  GLY A C   1 
ATOM   125  O  O   . GLY A 1 17  ? 0.901   -14.432 20.051  1    82.77  ? 13  GLY A O   1 
ATOM   126  N  N   . THR A 1 18  ? -0.368  -14.421 18.159  1    110.38 ? 14  THR A N   1 
ATOM   127  C  CA  . THR A 1 18  ? 0.461   -13.407 17.491  1    105.39 ? 14  THR A CA  1 
ATOM   128  C  C   . THR A 1 18  ? 0.373   -12.102 18.235  1    95.92  ? 14  THR A C   1 
ATOM   129  O  O   . THR A 1 18  ? 1.396   -11.392 18.282  1    75.32  ? 14  THR A O   1 
ATOM   130  C  CB  . THR A 1 18  ? -0.032  -13.261 16.054  1    112.11 ? 14  THR A CB  1 
ATOM   131  O  OG1 . THR A 1 18  ? -1.399  -12.877 16.165  1    118.58 ? 14  THR A OG1 1 
ATOM   132  C  CG2 . THR A 1 18  ? 0.08    -14.551 15.261  1    90.35  ? 14  THR A CG2 1 
ATOM   133  N  N   . TYR A 1 19  ? -0.794  -11.78  18.798  1    96.59  ? 15  TYR A N   1 
ATOM   134  C  CA  . TYR A 1 19  ? -0.944  -10.435 19.413  1    105.79 ? 15  TYR A CA  1 
ATOM   135  C  C   . TYR A 1 19  ? -1.172  -10.527 20.909  1    95.81  ? 15  TYR A C   1 
ATOM   136  O  O   . TYR A 1 19  ? -1.661  -9.539  21.492  1    81.08  ? 15  TYR A O   1 
ATOM   137  C  CB  . TYR A 1 19  ? -2.088  -9.671  18.747  1    119.05 ? 15  TYR A CB  1 
ATOM   138  C  CG  . TYR A 1 19  ? -1.689  -8.962  17.461  1    139.39 ? 15  TYR A CG  1 
ATOM   139  C  CD1 . TYR A 1 19  ? -1.15   -7.683  17.485  1    130.58 ? 15  TYR A CD1 1 
ATOM   140  C  CD2 . TYR A 1 19  ? -1.849  -9.575  16.225  1    139.95 ? 15  TYR A CD2 1 
ATOM   141  C  CE1 . TYR A 1 19  ? -0.783  -7.036  16.318  1    128.32 ? 15  TYR A CE1 1 
ATOM   142  C  CE2 . TYR A 1 19  ? -1.487  -8.938  15.051  1    123.5  ? 15  TYR A CE2 1 
ATOM   143  C  CZ  . TYR A 1 19  ? -0.954  -7.664  15.098  1    127.24 ? 15  TYR A CZ  1 
ATOM   144  O  OH  . TYR A 1 19  ? -0.594  -7.03   13.945  1    119.38 ? 15  TYR A OH  1 
ATOM   145  N  N   . GLY A 1 20  ? -0.809  -11.646 21.532  1    82.23  ? 16  GLY A N   1 
ATOM   146  C  CA  . GLY A 1 20  ? -0.928  -11.664 22.997  1    64.98  ? 16  GLY A CA  1 
ATOM   147  C  C   . GLY A 1 20  ? -0.934  -13.037 23.621  1    52.57  ? 16  GLY A C   1 
ATOM   148  O  O   . GLY A 1 20  ? -0.519  -14.007 22.966  1    52.19  ? 16  GLY A O   1 
ATOM   149  N  N   . VAL A 1 21  ? -1.392  -13.098 24.863  1    49.17  ? 17  VAL A N   1 
ATOM   150  C  CA  . VAL A 1 21  ? -1.416  -14.377 25.611  1    56.74  ? 17  VAL A CA  1 
ATOM   151  C  C   . VAL A 1 21  ? -2.869  -14.807 25.81   1    57.13  ? 17  VAL A C   1 
ATOM   152  O  O   . VAL A 1 21  ? -3.745  -13.927 25.845  1    64.04  ? 17  VAL A O   1 
ATOM   153  C  CB  . VAL A 1 21  ? -0.733  -14.103 26.96   1    57.28  ? 17  VAL A CB  1 
ATOM   154  C  CG1 . VAL A 1 21  ? -1.502  -13.077 27.782  1    65.81  ? 17  VAL A CG1 1 
ATOM   155  C  CG2 . VAL A 1 21  ? -0.503  -15.365 27.778  1    63     ? 17  VAL A CG2 1 
ATOM   156  N  N   . VAL A 1 22  ? -3.11   -16.109 25.885  1    41.45  ? 18  VAL A N   1 
ATOM   157  C  CA  . VAL A 1 22  ? -4.436  -16.61  26.198  1    31.74  ? 18  VAL A CA  1 
ATOM   158  C  C   . VAL A 1 22  ? -4.436  -17.109 27.637  1    32.82  ? 18  VAL A C   1 
ATOM   159  O  O   . VAL A 1 22  ? -3.54   -17.845 28.013  1    37.18  ? 18  VAL A O   1 
ATOM   160  C  CB  . VAL A 1 22  ? -4.804  -17.759 25.254  1    29.43  ? 18  VAL A CB  1 
ATOM   161  C  CG1 . VAL A 1 22  ? -6.236  -18.211 25.473  1    29.38  ? 18  VAL A CG1 1 
ATOM   162  C  CG2 . VAL A 1 22  ? -4.565  -17.394 23.796  1    31.31  ? 18  VAL A CG2 1 
ATOM   163  N  N   . TYR A 1 23  ? -5.454  -16.745 28.421  1    34.15  ? 19  TYR A N   1 
ATOM   164  C  CA  . TYR A 1 23  ? -5.632  -17.279 29.763  1    31.53  ? 19  TYR A CA  1 
ATOM   165  C  C   . TYR A 1 23  ? -6.85   -18.194 29.811  1    30.31  ? 19  TYR A C   1 
ATOM   166  O  O   . TYR A 1 23  ? -7.735  -18.112 28.969  1    36.06  ? 19  TYR A O   1 
ATOM   167  C  CB  . TYR A 1 23  ? -5.793  -16.162 30.792  1    34.97  ? 19  TYR A CB  1 
ATOM   168  C  CG  . TYR A 1 23  ? -4.533  -15.363 31.092  1    47.58  ? 19  TYR A CG  1 
ATOM   169  C  CD1 . TYR A 1 23  ? -4.173  -14.281 30.291  1    56.61  ? 19  TYR A CD1 1 
ATOM   170  C  CD2 . TYR A 1 23  ? -3.723  -15.664 32.188  1    48.13  ? 19  TYR A CD2 1 
ATOM   171  C  CE1 . TYR A 1 23  ? -3.036  -13.533 30.568  1    59.86  ? 19  TYR A CE1 1 
ATOM   172  C  CE2 . TYR A 1 23  ? -2.572  -14.94  32.456  1    59.96  ? 19  TYR A CE2 1 
ATOM   173  C  CZ  . TYR A 1 23  ? -2.221  -13.876 31.638  1    71.05  ? 19  TYR A CZ  1 
ATOM   174  O  OH  . TYR A 1 23  ? -1.088  -13.162 31.935  1    86.97  ? 19  TYR A OH  1 
ATOM   175  N  N   . LYS A 1 24  ? -6.876  -19.097 30.788  1    28.13  ? 20  LYS A N   1 
ATOM   176  C  CA  . LYS A 1 24  ? -8.098  -19.758 31.201  1    23.96  ? 20  LYS A CA  1 
ATOM   177  C  C   . LYS A 1 24  ? -8.641  -18.982 32.387  1    25.71  ? 20  LYS A C   1 
ATOM   178  O  O   . LYS A 1 24  ? -7.905  -18.664 33.338  1    25.6   ? 20  LYS A O   1 
ATOM   179  C  CB  . LYS A 1 24  ? -7.815  -21.205 31.608  1    25.68  ? 20  LYS A CB  1 
ATOM   180  C  CG  . LYS A 1 24  ? -8.91   -21.971 32.325  1    27.23  ? 20  LYS A CG  1 
ATOM   181  C  CD  . LYS A 1 24  ? -8.454  -23.344 32.805  1    29.42  ? 20  LYS A CD  1 
ATOM   182  C  CE  . LYS A 1 24  ? -9.562  -24.139 33.447  1    32.02  ? 20  LYS A CE  1 
ATOM   183  N  NZ  . LYS A 1 24  ? -9.334  -25.581 33.534  1    29.06  ? 20  LYS A NZ  1 
ATOM   184  N  N   . ALA A 1 25  ? -9.941  -18.67  32.32   1    23.56  ? 21  ALA A N   1 
ATOM   185  C  CA  . ALA A 1 25  ? -10.534 -17.898 33.395  1    21.59  ? 21  ALA A CA  1 
ATOM   186  C  C   . ALA A 1 25  ? -11.871 -18.514 33.764  1    24.03  ? 21  ALA A C   1 
ATOM   187  O  O   . ALA A 1 25  ? -12.381 -19.392 33.075  1    32.47  ? 21  ALA A O   1 
ATOM   188  C  CB  . ALA A 1 25  ? -10.69  -16.477 32.956  1    18.5   ? 21  ALA A CB  1 
ATOM   189  N  N   . ARG A 1 26  ? -12.45  -17.998 34.827  1    24.05  ? 22  ARG A N   1 
ATOM   190  C  CA  . ARG A 1 26  ? -13.685 -18.525 35.356  1    26.9   ? 22  ARG A CA  1 
ATOM   191  C  C   . ARG A 1 26  ? -14.603 -17.326 35.568  1    25.98  ? 22  ARG A C   1 
ATOM   192  O  O   . ARG A 1 26  ? -14.2   -16.336 36.18   1    22.91  ? 22  ARG A O   1 
ATOM   193  C  CB  . ARG A 1 26  ? -13.351 -19.174 36.708  1    30.89  ? 22  ARG A CB  1 
ATOM   194  C  CG  . ARG A 1 26  ? -14.357 -20.19  37.219  1    38.91  ? 22  ARG A CG  1 
ATOM   195  C  CD  . ARG A 1 26  ? -13.797 -20.902 38.447  1    49.34  ? 22  ARG A CD  1 
ATOM   196  N  NE  . ARG A 1 26  ? -13.915 -20.019 39.619  1    61.01  ? 22  ARG A NE  1 
ATOM   197  C  CZ  . ARG A 1 26  ? -12.919 -19.582 40.392  1    59.38  ? 22  ARG A CZ  1 
ATOM   198  N  NH1 . ARG A 1 26  ? -11.669 -19.911 40.088  1    57.39  ? 22  ARG A NH1 1 
ATOM   199  N  NH2 . ARG A 1 26  ? -13.189 -18.812 41.439  1    51.46  ? 22  ARG A NH2 1 
ATOM   200  N  N   . ASN A 1 27  ? -15.814 -17.415 35.008  1    25.92  ? 23  ASN A N   1 
ATOM   201  C  CA  . ASN A 1 27  ? -16.874 -16.449 35.264  1    21.94  ? 23  ASN A CA  1 
ATOM   202  C  C   . ASN A 1 27  ? -17.332 -16.684 36.693  1    20.53  ? 23  ASN A C   1 
ATOM   203  O  O   . ASN A 1 27  ? -17.7   -17.795 37.038  1    21.98  ? 23  ASN A O   1 
ATOM   204  C  CB  . ASN A 1 27  ? -18.032 -16.665 34.291  1    19.66  ? 23  ASN A CB  1 
ATOM   205  C  CG  . ASN A 1 27  ? -19.153 -15.66  34.412  1    18.61  ? 23  ASN A CG  1 
ATOM   206  O  OD1 . ASN A 1 27  ? -19.559 -15.281 35.519  1    19.42  ? 23  ASN A OD1 1 
ATOM   207  N  ND2 . ASN A 1 27  ? -19.666 -15.216 33.273  1    16.82  ? 23  ASN A ND2 1 
ATOM   208  N  N   . LYS A 1 28  ? -17.306 -15.648 37.528  1    20.63  ? 24  LYS A N   1 
ATOM   209  C  CA  . LYS A 1 28  ? -17.483 -15.826 38.959  1    18.31  ? 24  LYS A CA  1 
ATOM   210  C  C   . LYS A 1 28  ? -18.96  -15.803 39.323  1    17.87  ? 24  LYS A C   1 
ATOM   211  O  O   . LYS A 1 28  ? -19.309 -15.956 40.49   1    18.38  ? 24  LYS A O   1 
ATOM   212  C  CB  . LYS A 1 28  ? -16.822 -14.654 39.679  1    19.88  ? 24  LYS A CB  1 
ATOM   213  C  CG  . LYS A 1 28  ? -15.344 -14.806 39.911  1    25.16  ? 24  LYS A CG  1 
ATOM   214  C  CD  . LYS A 1 28  ? -14.82  -13.623 40.738  1    30.5   ? 24  LYS A CD  1 
ATOM   215  C  CE  . LYS A 1 28  ? -14.371 -12.429 39.928  1    31.03  ? 24  LYS A CE  1 
ATOM   216  N  NZ  . LYS A 1 28  ? -14.113 -11.305 40.843  1    34.31  ? 24  LYS A NZ  1 
ATOM   217  N  N   . LEU A 1 29  ? -19.826 -15.597 38.328  1    18.34  ? 25  LEU A N   1 
ATOM   218  C  CA  . LEU A 1 29  ? -21.248 -15.472 38.605  1    18.38  ? 25  LEU A CA  1 
ATOM   219  C  C   . LEU A 1 29  ? -22.019 -16.675 38.067  1    19.92  ? 25  LEU A C   1 
ATOM   220  O  O   . LEU A 1 29  ? -22.935 -17.137 38.752  1    21.42  ? 25  LEU A O   1 
ATOM   221  C  CB  . LEU A 1 29  ? -21.761 -14.14  38.077  1    16.18  ? 25  LEU A CB  1 
ATOM   222  C  CG  . LEU A 1 29  ? -21.309 -12.926 38.896  1    14.77  ? 25  LEU A CG  1 
ATOM   223  C  CD1 . LEU A 1 29  ? -21.823 -11.642 38.285  1    13.96  ? 25  LEU A CD1 1 
ATOM   224  C  CD2 . LEU A 1 29  ? -21.696 -13.052 40.365  1    14.06  ? 25  LEU A CD2 1 
ATOM   225  N  N   . THR A 1 30  ? -21.604 -17.181 36.89   1    17.3   ? 26  THR A N   1 
ATOM   226  C  CA  . THR A 1 30  ? -22.259 -18.299 36.242  1    19.11  ? 26  THR A CA  1 
ATOM   227  C  C   . THR A 1 30  ? -21.507 -19.615 36.453  1    24.83  ? 26  THR A C   1 
ATOM   228  O  O   . THR A 1 30  ? -22.109 -20.69  36.279  1    27.61  ? 26  THR A O   1 
ATOM   229  C  CB  . THR A 1 30  ? -22.449 -18.018 34.753  1    16.96  ? 26  THR A CB  1 
ATOM   230  O  OG1 . THR A 1 30  ? -21.186 -18.03  34.095  1    16.64  ? 26  THR A OG1 1 
ATOM   231  C  CG2 . THR A 1 30  ? -23.113 -16.678 34.532  1    15.9   ? 26  THR A CG2 1 
ATOM   232  N  N   . GLY A 1 31  ? -20.187 -19.531 36.735  1    23.46  ? 27  GLY A N   1 
ATOM   233  C  CA  . GLY A 1 31  ? -19.318 -20.687 36.927  1    19.5   ? 27  GLY A CA  1 
ATOM   234  C  C   . GLY A 1 31  ? -18.565 -21.049 35.649  1    20.23  ? 27  GLY A C   1 
ATOM   235  O  O   . GLY A 1 31  ? -17.641 -21.875 35.664  1    22.58  ? 27  GLY A O   1 
ATOM   236  N  N   . GLU A 1 32  ? -18.951 -20.411 34.543  1    17.57  ? 28  GLU A N   1 
ATOM   237  C  CA  . GLU A 1 32  ? -18.476 -20.84  33.24   1    19.28  ? 28  GLU A CA  1 
ATOM   238  C  C   . GLU A 1 32  ? -16.966 -20.636 33.163  1    20.6   ? 28  GLU A C   1 
ATOM   239  O  O   . GLU A 1 32  ? -16.444 -19.575 33.532  1    21.58  ? 28  GLU A O   1 
ATOM   240  C  CB  . GLU A 1 32  ? -19.275 -20.126 32.142  1    17.9   ? 28  GLU A CB  1 
ATOM   241  C  CG  . GLU A 1 32  ? -18.832 -20.453 30.732  1    17.73  ? 28  GLU A CG  1 
ATOM   242  C  CD  . GLU A 1 32  ? -19.615 -19.779 29.609  1    23.86  ? 28  GLU A CD  1 
ATOM   243  O  OE1 . GLU A 1 32  ? -20.127 -18.624 29.754  1    23.76  ? 28  GLU A OE1 1 
ATOM   244  O  OE2 . GLU A 1 32  ? -19.649 -20.401 28.512  1    27.52  ? 28  GLU A OE2 1 
ATOM   245  N  N   . VAL A 1 33  ? -16.282 -21.652 32.638  1    19.92  ? 29  VAL A N   1 
ATOM   246  C  CA  . VAL A 1 33  ? -14.866 -21.546 32.345  1    20.5   ? 29  VAL A CA  1 
ATOM   247  C  C   . VAL A 1 33  ? -14.707 -21.073 30.906  1    24.44  ? 29  VAL A C   1 
ATOM   248  O  O   . VAL A 1 33  ? -15.352 -21.625 30.008  1    26.87  ? 29  VAL A O   1 
ATOM   249  C  CB  . VAL A 1 33  ? -14.171 -22.898 32.576  1    18.44  ? 29  VAL A CB  1 
ATOM   250  C  CG1 . VAL A 1 33  ? -12.717 -22.861 32.145  1    20.62  ? 29  VAL A CG1 1 
ATOM   251  C  CG2 . VAL A 1 33  ? -14.238 -23.327 34.029  1    17.96  ? 29  VAL A CG2 1 
ATOM   252  N  N   . VAL A 1 34  ? -13.807 -20.093 30.694  1    24.51  ? 30  VAL A N   1 
ATOM   253  C  CA  . VAL A 1 34  ? -13.575 -19.505 29.37   1    24.97  ? 30  VAL A CA  1 
ATOM   254  C  C   . VAL A 1 34  ? -12.077 -19.377 29.073  1    26.25  ? 30  VAL A C   1 
ATOM   255  O  O   . VAL A 1 34  ? -11.227 -19.481 29.957  1    32.71  ? 30  VAL A O   1 
ATOM   256  C  CB  . VAL A 1 34  ? -14.218 -18.106 29.279  1    24.11  ? 30  VAL A CB  1 
ATOM   257  C  CG1 . VAL A 1 34  ? -15.702 -18.158 29.587  1    23.39  ? 30  VAL A CG1 1 
ATOM   258  C  CG2 . VAL A 1 34  ? -13.555 -17.137 30.253  1    20.87  ? 30  VAL A CG2 1 
ATOM   259  N  N   . ALA A 1 35  ? -11.774 -19.087 27.817  1    23.83  ? 31  ALA A N   1 
ATOM   260  C  CA  . ALA A 1 35  ? -10.457 -18.677 27.388  1    24.35  ? 31  ALA A CA  1 
ATOM   261  C  C   . ALA A 1 35  ? -10.522 -17.19  27.072  1    25.86  ? 31  ALA A C   1 
ATOM   262  O  O   . ALA A 1 35  ? -11.3   -16.832 26.187  1    27.18  ? 31  ALA A O   1 
ATOM   263  C  CB  . ALA A 1 35  ? -10.071 -19.462 26.147  1    19.53  ? 31  ALA A CB  1 
ATOM   264  N  N   . LEU A 1 36  ? -9.727  -16.353 27.775  1    23.89  ? 32  LEU A N   1 
ATOM   265  C  CA  . LEU A 1 36  ? -9.558  -14.942 27.421  1    23.48  ? 32  LEU A CA  1 
ATOM   266  C  C   . LEU A 1 36  ? -8.354  -14.767 26.5    1    25.22  ? 32  LEU A C   1 
ATOM   267  O  O   . LEU A 1 36  ? -7.248  -15.106 26.873  1    29.85  ? 32  LEU A O   1 
ATOM   268  C  CB  . LEU A 1 36  ? -9.358  -14.108 28.668  1    21.54  ? 32  LEU A CB  1 
ATOM   269  C  CG  . LEU A 1 36  ? -10.437 -14.246 29.736  1    25.28  ? 32  LEU A CG  1 
ATOM   270  C  CD1 . LEU A 1 36  ? -10.105 -13.421 30.964  1    22.04  ? 32  LEU A CD1 1 
ATOM   271  C  CD2 . LEU A 1 36  ? -11.807 -13.839 29.189  1    29.48  ? 32  LEU A CD2 1 
ATOM   272  N  N   . LYS A 1 37  ? -8.559  -14.247 25.293  1    26.16  ? 33  LYS A N   1 
ATOM   273  C  CA  . LYS A 1 37  ? -7.452  -13.835 24.443  1    29.24  ? 33  LYS A CA  1 
ATOM   274  C  C   . LYS A 1 37  ? -7.297  -12.323 24.59   1    32.8   ? 33  LYS A C   1 
ATOM   275  O  O   . LYS A 1 37  ? -8.159  -11.568 24.18   1    42.27  ? 33  LYS A O   1 
ATOM   276  C  CB  . LYS A 1 37  ? -7.681  -14.287 22.995  1    28.44  ? 33  LYS A CB  1 
ATOM   277  C  CG  . LYS A 1 37  ? -6.586  -13.953 22.027  1    29.02  ? 33  LYS A CG  1 
ATOM   278  C  CD  . LYS A 1 37  ? -6.802  -14.351 20.571  1    35.68  ? 33  LYS A CD  1 
ATOM   279  C  CE  . LYS A 1 37  ? -7.11   -15.817 20.356  1    42.55  ? 33  LYS A CE  1 
ATOM   280  N  NZ  . LYS A 1 37  ? -7.053  -16.217 18.946  1    36.59  ? 33  LYS A NZ  1 
ATOM   281  N  N   . LYS A 1 38  ? -6.231  -11.881 25.247  1    38.45  ? 34  LYS A N   1 
ATOM   282  C  CA  . LYS A 1 38  ? -5.96   -10.463 25.389  1    42.06  ? 34  LYS A CA  1 
ATOM   283  C  C   . LYS A 1 38  ? -5.236  -9.973  24.142  1    48.42  ? 34  LYS A C   1 
ATOM   284  O  O   . LYS A 1 38  ? -4.345  -10.66  23.656  1    57.67  ? 34  LYS A O   1 
ATOM   285  C  CB  . LYS A 1 38  ? -5.111  -10.194 26.633  1    40.23  ? 34  LYS A CB  1 
ATOM   286  C  CG  . LYS A 1 38  ? -4.78   -8.729  26.821  1    42.69  ? 34  LYS A CG  1 
ATOM   287  C  CD  . LYS A 1 38  ? -4.17   -8.384  28.177  1    50.5   ? 34  LYS A CD  1 
ATOM   288  C  CE  . LYS A 1 38  ? -2.917  -9.162  28.501  1    56.77  ? 34  LYS A CE  1 
ATOM   289  N  NZ  . LYS A 1 38  ? -2.202  -8.47   29.584  1    58.85  ? 34  LYS A NZ  1 
ATOM   290  N  N   . ILE A 1 39  ? -5.669  -8.811  23.631  1    50.25  ? 35  ILE A N   1 
ATOM   291  C  CA  . ILE A 1 39  ? -5.061  -8.088  22.522  1    47.39  ? 35  ILE A CA  1 
ATOM   292  C  C   . ILE A 1 39  ? -4.804  -6.672  23.03   1    46.91  ? 35  ILE A C   1 
ATOM   293  O  O   . ILE A 1 39  ? -5.736  -6.033  23.517  1    49.57  ? 35  ILE A O   1 
ATOM   294  C  CB  . ILE A 1 39  ? -5.99   -8.127  21.285  1    47.85  ? 35  ILE A CB  1 
ATOM   295  C  CG1 . ILE A 1 39  ? -6.086  -9.543  20.686  1    53.24  ? 35  ILE A CG1 1 
ATOM   296  C  CG2 . ILE A 1 39  ? -5.546  -7.129  20.218  1    43.08  ? 35  ILE A CG2 1 
ATOM   297  C  CD1 . ILE A 1 39  ? -7.346  -9.823  19.888  1    47.95  ? 35  ILE A CD1 1 
ATOM   298  N  N   . ARG A 1 40  ? -3.547  -6.204  22.975  1    53.33  ? 36  ARG A N   1 
ATOM   299  C  CA  . ARG A 1 40  ? -3.24   -4.872  23.49   1    67.18  ? 36  ARG A CA  1 
ATOM   300  C  C   . ARG A 1 40  ? -3.238  -3.862  22.348  1    68.04  ? 36  ARG A C   1 
ATOM   301  O  O   . ARG A 1 40  ? -2.747  -4.151  21.256  1    73.78  ? 36  ARG A O   1 
ATOM   302  C  CB  . ARG A 1 40  ? -1.968  -4.773  24.334  1    65.79  ? 36  ARG A CB  1 
ATOM   303  C  CG  . ARG A 1 40  ? -2.175  -5.027  25.822  1    75.69  ? 36  ARG A CG  1 
ATOM   304  C  CD  . ARG A 1 40  ? -0.913  -4.844  26.682  1    86.54  ? 36  ARG A CD  1 
ATOM   305  N  NE  . ARG A 1 40  ? 0.251   -5.48   26.053  1    92.52  ? 36  ARG A NE  1 
ATOM   306  C  CZ  . ARG A 1 40  ? 0.523   -6.785  25.988  1    88.91  ? 36  ARG A CZ  1 
ATOM   307  N  NH1 . ARG A 1 40  ? -0.084  -7.649  26.783  1    81.87  ? 36  ARG A NH1 1 
ATOM   308  N  NH2 . ARG A 1 40  ? 1.442   -7.215  25.142  1    85.83  ? 36  ARG A NH2 1 
ATOM   309  N  N   . LEU A 1 41  ? -3.822  -2.694  22.633  1    59.3   ? 37  LEU A N   1 
ATOM   310  C  CA  . LEU A 1 41  ? -3.972  -1.622  21.664  1    65.84  ? 37  LEU A CA  1 
ATOM   311  C  C   . LEU A 1 41  ? -3.057  -0.462  22.049  1    83.61  ? 37  LEU A C   1 
ATOM   312  O  O   . LEU A 1 41  ? -2.614  0.275   21.173  1    98.15  ? 37  LEU A O   1 
ATOM   313  C  CB  . LEU A 1 41  ? -5.427  -1.159  21.595  1    57.67  ? 37  LEU A CB  1 
ATOM   314  C  CG  . LEU A 1 41  ? -6.482  -2.231  21.314  1    48.63  ? 37  LEU A CG  1 
ATOM   315  C  CD1 . LEU A 1 41  ? -7.878  -1.625  21.343  1    50.42  ? 37  LEU A CD1 1 
ATOM   316  C  CD2 . LEU A 1 41  ? -6.195  -2.909  20.006  1    44.29  ? 37  LEU A CD2 1 
ATOM   317  N  N   . ASP A 1 42  ? -2.825  -0.286  23.366  1    96.05  ? 38  ASP A N   1 
ATOM   318  C  CA  . ASP A 1 42  ? -1.898  0.693   23.936  1    88.54  ? 38  ASP A CA  1 
ATOM   319  C  C   . ASP A 1 42  ? -0.542  0.616   23.232  1    87.17  ? 38  ASP A C   1 
ATOM   320  O  O   . ASP A 1 42  ? 0.059   1.64    22.903  1    69.92  ? 38  ASP A O   1 
ATOM   321  C  CB  . ASP A 1 42  ? -1.786  0.583   25.459  1    85.41  ? 38  ASP A CB  1 
ATOM   322  C  CG  . ASP A 1 42  ? -1.392  -0.758  26.081  1    93.5   ? 38  ASP A CG  1 
ATOM   323  O  OD1 . ASP A 1 42  ? -2.164  -1.75   25.952  1    108.39 ? 38  ASP A OD1 1 
ATOM   324  O  OD2 . ASP A 1 42  ? -0.336  -0.797  26.749  1    84.65  ? 38  ASP A OD2 1 
ATOM   325  N  N   . THR A 1 43  ? -0.085  -0.627  23.019  1    97.05  ? 39  THR A N   1 
ATOM   326  C  CA  . THR A 1 43  ? 1.158   -0.953  22.335  1    92.85  ? 39  THR A CA  1 
ATOM   327  C  C   . THR A 1 43  ? 0.85    -1.276  20.87   1    90.82  ? 39  THR A C   1 
ATOM   328  O  O   . THR A 1 43  ? 1.562   -2.062  20.241  1    74.8   ? 39  THR A O   1 
ATOM   329  C  CB  . THR A 1 43  ? 1.857   -2.113  23.056  1    87.69  ? 39  THR A CB  1 
ATOM   330  O  OG1 . THR A 1 43  ? 3.163   -2.285  22.51   1    83.07  ? 39  THR A OG1 1 
ATOM   331  C  CG2 . THR A 1 43  ? 1.064   -3.41   22.995  1    86.43  ? 39  THR A CG2 1 
ATOM   332  N  N   . GLU A 1 44  ? -0.235  -0.69   20.344  1    90.8   ? 40  GLU A N   1 
ATOM   333  C  CA  . GLU A 1 44  ? -0.595  -0.793  18.938  1    77.3   ? 40  GLU A CA  1 
ATOM   334  C  C   . GLU A 1 44  ? -0.6    0.614   18.347  1    76.28  ? 40  GLU A C   1 
ATOM   335  O  O   . GLU A 1 44  ? -1.144  1.539   18.95   1    79.66  ? 40  GLU A O   1 
ATOM   336  C  CB  . GLU A 1 44  ? -1.943  -1.491  18.769  1    65.27  ? 40  GLU A CB  1 
ATOM   337  C  CG  . GLU A 1 44  ? -1.82   -2.961  18.374  1    77.88  ? 40  GLU A CG  1 
ATOM   338  C  CD  . GLU A 1 44  ? -1.247  -3.197  16.982  1    87.4   ? 40  GLU A CD  1 
ATOM   339  O  OE1 . GLU A 1 44  ? -1.78   -2.645  15.984  1    87.34  ? 40  GLU A OE1 1 
ATOM   340  O  OE2 . GLU A 1 44  ? -0.259  -3.956  16.899  1    87.44  ? 40  GLU A OE2 1 
ATOM   341  N  N   . THR A 1 45  ? 0.006   0.768   17.166  1    69.23  ? 41  THR A N   1 
ATOM   342  C  CA  . THR A 1 45  ? 0.188   2.089   16.579  1    66.29  ? 41  THR A CA  1 
ATOM   343  C  C   . THR A 1 45  ? -0.67   2.266   15.318  1    60.14  ? 41  THR A C   1 
ATOM   344  O  O   . THR A 1 45  ? -0.832  3.397   14.846  1    57.54  ? 41  THR A O   1 
ATOM   345  C  CB  . THR A 1 45  ? 1.676   2.383   16.35   1    67.3   ? 41  THR A CB  1 
ATOM   346  O  OG1 . THR A 1 45  ? 2.258   2.332   17.651  1    75.03  ? 41  THR A OG1 1 
ATOM   347  C  CG2 . THR A 1 45  ? 1.928   3.733   15.693  1    65.36  ? 41  THR A CG2 1 
ATOM   348  N  N   . GLU A 1 46  ? -1.207  1.153   14.786  1    46.12  ? 42  GLU A N   1 
ATOM   349  C  CA  . GLU A 1 46  ? -2.085  1.161   13.627  1    39.71  ? 42  GLU A CA  1 
ATOM   350  C  C   . GLU A 1 46  ? -3.512  0.775   14.016  1    34.68  ? 42  GLU A C   1 
ATOM   351  O  O   . GLU A 1 46  ? -4.234  0.217   13.179  1    35.38  ? 42  GLU A O   1 
ATOM   352  C  CB  . GLU A 1 46  ? -1.618  0.203   12.524  1    45.32  ? 42  GLU A CB  1 
ATOM   353  C  CG  . GLU A 1 46  ? -0.297  0.599   11.864  1    47.14  ? 42  GLU A CG  1 
ATOM   354  C  CD  . GLU A 1 46  ? -0.313  1.936   11.135  1    48.36  ? 42  GLU A CD  1 
ATOM   355  O  OE1 . GLU A 1 46  ? -0.885  1.96    10.01   1    47.04  ? 42  GLU A OE1 1 
ATOM   356  O  OE2 . GLU A 1 46  ? 0.203   2.947   11.703  1    36.91  ? 42  GLU A OE2 1 
ATOM   357  N  N   . GLY A 1 47  ? -3.907  1.072   15.267  1    29.63  ? 43  GLY A N   1 
ATOM   358  C  CA  . GLY A 1 47  ? -5.266  0.847   15.744  1    27.02  ? 43  GLY A CA  1 
ATOM   359  C  C   . GLY A 1 47  ? -5.546  -0.642  15.92   1    26.37  ? 43  GLY A C   1 
ATOM   360  O  O   . GLY A 1 47  ? -4.637  -1.396  16.229  1    33.01  ? 43  GLY A O   1 
ATOM   361  N  N   . VAL A 1 48  ? -6.795  -1.076  15.738  1    22.03  ? 44  VAL A N   1 
ATOM   362  C  CA  . VAL A 1 48  ? -7.079  -2.474  15.961  1    20.73  ? 44  VAL A CA  1 
ATOM   363  C  C   . VAL A 1 48  ? -6.475  -3.304  14.827  1    22.83  ? 44  VAL A C   1 
ATOM   364  O  O   . VAL A 1 48  ? -6.716  -3.056  13.655  1    21.89  ? 44  VAL A O   1 
ATOM   365  C  CB  . VAL A 1 48  ? -8.596  -2.715  16.097  1    18.82  ? 44  VAL A CB  1 
ATOM   366  C  CG1 . VAL A 1 48  ? -8.929  -4.19   16.371  1    16.9   ? 44  VAL A CG1 1 
ATOM   367  C  CG2 . VAL A 1 48  ? -9.201  -1.797  17.132  1    16.78  ? 44  VAL A CG2 1 
ATOM   368  N  N   . PRO A 1 49  ? -5.71   -4.373  15.124  1    27.33  ? 45  PRO A N   1 
ATOM   369  C  CA  . PRO A 1 49  ? -5.059  -5.157  14.071  1    27.26  ? 45  PRO A CA  1 
ATOM   370  C  C   . PRO A 1 49  ? -6.117  -5.707  13.134  1    30.31  ? 45  PRO A C   1 
ATOM   371  O  O   . PRO A 1 49  ? -7.188  -6.086  13.588  1    31.05  ? 45  PRO A O   1 
ATOM   372  C  CB  . PRO A 1 49  ? -4.404  -6.312  14.84   1    24.66  ? 45  PRO A CB  1 
ATOM   373  C  CG  . PRO A 1 49  ? -4.2    -5.761  16.204  1    25.15  ? 45  PRO A CG  1 
ATOM   374  C  CD  . PRO A 1 49  ? -5.407  -4.877  16.472  1    26.9   ? 45  PRO A CD  1 
ATOM   375  N  N   . SER A 1 50  ? -5.765  -5.846  11.855  1    30.53  ? 46  SER A N   1 
ATOM   376  C  CA  . SER A 1 50  ? -6.655  -6.471  10.891  1    27.22  ? 46  SER A CA  1 
ATOM   377  C  C   . SER A 1 50  ? -6.978  -7.911  11.264  1    28.56  ? 46  SER A C   1 
ATOM   378  O  O   . SER A 1 50  ? -8.084  -8.365  10.984  1    35.75  ? 46  SER A O   1 
ATOM   379  C  CB  . SER A 1 50  ? -6.154  -6.362  9.493   1    25.35  ? 46  SER A CB  1 
ATOM   380  O  OG  . SER A 1 50  ? -5.027  -7.195  9.323   1    33.38  ? 46  SER A OG  1 
ATOM   381  N  N   . THR A 1 51  ? -6.046  -8.635  11.889  1    30.42  ? 47  THR A N   1 
ATOM   382  C  CA  . THR A 1 51  ? -6.321  -10.023 12.287  1    32.8   ? 47  THR A CA  1 
ATOM   383  C  C   . THR A 1 51  ? -7.498  -10.085 13.265  1    25.88  ? 47  THR A C   1 
ATOM   384  O  O   . THR A 1 51  ? -8.372  -10.932 13.124  1    24.02  ? 47  THR A O   1 
ATOM   385  C  CB  . THR A 1 51  ? -5.093  -10.737 12.861  1    35.36  ? 47  THR A CB  1 
ATOM   386  O  OG1 . THR A 1 51  ? -4.489  -9.862  13.813  1    48.55  ? 47  THR A OG1 1 
ATOM   387  C  CG2 . THR A 1 51  ? -4.056  -11.043 11.795  1    39.01  ? 47  THR A CG2 1 
ATOM   388  N  N   . ALA A 1 52  ? -7.521  -9.165  14.234  1    23.31  ? 48  ALA A N   1 
ATOM   389  C  CA  . ALA A 1 52  ? -8.543  -9.197  15.263  1    25.65  ? 48  ALA A CA  1 
ATOM   390  C  C   . ALA A 1 52  ? -9.886  -8.781  14.654  1    31.85  ? 48  ALA A C   1 
ATOM   391  O  O   . ALA A 1 52  ? -10.928 -9.326  15.05   1    32.45  ? 48  ALA A O   1 
ATOM   392  C  CB  . ALA A 1 52  ? -8.165  -8.359  16.478  1    18.36  ? 48  ALA A CB  1 
ATOM   393  N  N   . ILE A 1 53  ? -9.853  -7.813  13.715  1    27.04  ? 49  ILE A N   1 
ATOM   394  C  CA  . ILE A 1 53  ? -11.07  -7.352  13.069  1    28     ? 49  ILE A CA  1 
ATOM   395  C  C   . ILE A 1 53  ? -11.708 -8.502  12.283  1    28     ? 49  ILE A C   1 
ATOM   396  O  O   . ILE A 1 53  ? -12.917 -8.705  12.326  1    26.07  ? 49  ILE A O   1 
ATOM   397  C  CB  . ILE A 1 53  ? -10.781 -6.112  12.215  1    27.83  ? 49  ILE A CB  1 
ATOM   398  C  CG1 . ILE A 1 53  ? -10.653 -4.903  13.119  1    27.42  ? 49  ILE A CG1 1 
ATOM   399  C  CG2 . ILE A 1 53  ? -11.901 -5.912  11.2    1    28.95  ? 49  ILE A CG2 1 
ATOM   400  C  CD1 . ILE A 1 53  ? -10.07  -3.687  12.444  1    28.45  ? 49  ILE A CD1 1 
ATOM   401  N  N   . ARG A 1 54  ? -10.881 -9.294  11.614  1    25.79  ? 50  ARG A N   1 
ATOM   402  C  CA  . ARG A 1 54  ? -11.393 -10.453 10.913  1    25.09  ? 50  ARG A CA  1 
ATOM   403  C  C   . ARG A 1 54  ? -11.838 -11.523 11.899  1    29.62  ? 50  ARG A C   1 
ATOM   404  O  O   . ARG A 1 54  ? -12.91  -12.099 11.741  1    32.76  ? 50  ARG A O   1 
ATOM   405  C  CB  . ARG A 1 54  ? -10.329 -11.046 9.993   1    22.17  ? 50  ARG A CB  1 
ATOM   406  C  CG  . ARG A 1 54  ? -10.093 -10.163 8.78    1    23.29  ? 50  ARG A CG  1 
ATOM   407  C  CD  . ARG A 1 54  ? -9.039  -10.73  7.862   1    23.39  ? 50  ARG A CD  1 
ATOM   408  N  NE  . ARG A 1 54  ? -8.96   -9.868  6.685   1    23.39  ? 50  ARG A NE  1 
ATOM   409  C  CZ  . ARG A 1 54  ? -8.017  -10.005 5.756   1    23.91  ? 50  ARG A CZ  1 
ATOM   410  N  NH1 . ARG A 1 54  ? -7.118  -10.966 5.885   1    22.13  ? 50  ARG A NH1 1 
ATOM   411  N  NH2 . ARG A 1 54  ? -7.967  -9.159  4.734   1    20.62  ? 50  ARG A NH2 1 
ATOM   412  N  N   . GLU A 1 55  ? -10.982 -11.868 12.862  1    33.37  ? 51  GLU A N   1 
ATOM   413  C  CA  . GLU A 1 55  ? -11.333 -12.94  13.789  1    32.67  ? 51  GLU A CA  1 
ATOM   414  C  C   . GLU A 1 55  ? -12.711 -12.656 14.411  1    28.95  ? 51  GLU A C   1 
ATOM   415  O  O   . GLU A 1 55  ? -13.579 -13.516 14.388  1    25.67  ? 51  GLU A O   1 
ATOM   416  C  CB  . GLU A 1 55  ? -10.22  -13.113 14.824  1    33.28  ? 51  GLU A CB  1 
ATOM   417  C  CG  . GLU A 1 55  ? -10.596 -14.094 15.926  1    38.77  ? 51  GLU A CG  1 
ATOM   418  C  CD  . GLU A 1 55  ? -9.44   -14.832 16.581  1    39.96  ? 51  GLU A CD  1 
ATOM   419  O  OE1 . GLU A 1 55  ? -8.426  -14.196 16.884  1    34.51  ? 51  GLU A OE1 1 
ATOM   420  O  OE2 . GLU A 1 55  ? -9.569  -16.075 16.748  1    50.88  ? 51  GLU A OE2 1 
ATOM   421  N  N   . ILE A 1 56  ? -12.914 -11.433 14.92   1    24.51  ? 52  ILE A N   1 
ATOM   422  C  CA  . ILE A 1 56  ? -14.104 -11.107 15.667  1    25.54  ? 52  ILE A CA  1 
ATOM   423  C  C   . ILE A 1 56  ? -15.296 -11.107 14.71   1    29.46  ? 52  ILE A C   1 
ATOM   424  O  O   . ILE A 1 56  ? -16.295 -11.775 14.985  1    32.06  ? 52  ILE A O   1 
ATOM   425  C  CB  . ILE A 1 56  ? -13.997 -9.77   16.427  1    24.35  ? 52  ILE A CB  1 
ATOM   426  C  CG1 . ILE A 1 56  ? -12.824 -9.74   17.421  1    24.89  ? 52  ILE A CG1 1 
ATOM   427  C  CG2 . ILE A 1 56  ? -15.312 -9.494  17.146  1    21.13  ? 52  ILE A CG2 1 
ATOM   428  C  CD1 . ILE A 1 56  ? -12.502 -8.368  17.993  1    20.16  ? 52  ILE A CD1 1 
ATOM   429  N  N   . SER A 1 57  ? -15.203 -10.334 13.619  1    27.06  ? 53  SER A N   1 
ATOM   430  C  CA  . SER A 1 57  ? -16.315 -10.184 12.684  1    28.09  ? 53  SER A CA  1 
ATOM   431  C  C   . SER A 1 57  ? -16.759 -11.542 12.11   1    29.45  ? 53  SER A C   1 
ATOM   432  O  O   . SER A 1 57  ? -17.954 -11.807 11.987  1    34.85  ? 53  SER A O   1 
ATOM   433  C  CB  . SER A 1 57  ? -16.024 -9.17   11.602  1    27.17  ? 53  SER A CB  1 
ATOM   434  O  OG  . SER A 1 57  ? -14.88  -9.556  10.838  1    31.09  ? 53  SER A OG  1 
ATOM   435  N  N   . LEU A 1 58  ? -15.816 -12.417 11.778  1    24.45  ? 54  LEU A N   1 
ATOM   436  C  CA  . LEU A 1 58  ? -16.171 -13.68  11.171  1    26.29  ? 54  LEU A CA  1 
ATOM   437  C  C   . LEU A 1 58  ? -16.671 -14.663 12.215  1    30.04  ? 54  LEU A C   1 
ATOM   438  O  O   . LEU A 1 58  ? -17.573 -15.438 11.922  1    37.99  ? 54  LEU A O   1 
ATOM   439  C  CB  . LEU A 1 58  ? -15.039 -14.244 10.329  1    22.91  ? 54  LEU A CB  1 
ATOM   440  C  CG  . LEU A 1 58  ? -14.569 -13.272 9.24    1    25.72  ? 54  LEU A CG  1 
ATOM   441  C  CD1 . LEU A 1 58  ? -13.38  -13.799 8.456   1    24.09  ? 54  LEU A CD1 1 
ATOM   442  C  CD2 . LEU A 1 58  ? -15.699 -12.916 8.324   1    22.24  ? 54  LEU A CD2 1 
ATOM   443  N  N   . LEU A 1 59  ? -16.106 -14.662 13.422  1    33.89  ? 55  LEU A N   1 
ATOM   444  C  CA  . LEU A 1 59  ? -16.552 -15.637 14.416  1    32.41  ? 55  LEU A CA  1 
ATOM   445  C  C   . LEU A 1 59  ? -17.94  -15.28  14.951  1    36.97  ? 55  LEU A C   1 
ATOM   446  O  O   . LEU A 1 59  ? -18.671 -16.171 15.36   1    41.13  ? 55  LEU A O   1 
ATOM   447  C  CB  . LEU A 1 59  ? -15.599 -15.741 15.591  1    31.13  ? 55  LEU A CB  1 
ATOM   448  C  CG  . LEU A 1 59  ? -14.409 -16.658 15.377  1    32.3   ? 55  LEU A CG  1 
ATOM   449  C  CD1 . LEU A 1 59  ? -13.519 -16.602 16.623  1    28.9   ? 55  LEU A CD1 1 
ATOM   450  C  CD2 . LEU A 1 59  ? -14.928 -18.042 15.058  1    31.1   ? 55  LEU A CD2 1 
ATOM   451  N  N   . LYS A 1 60  ? -18.263 -13.983 15.026  1    39.24  ? 56  LYS A N   1 
ATOM   452  C  CA  . LYS A 1 60  ? -19.572 -13.522 15.456  1    39.93  ? 56  LYS A CA  1 
ATOM   453  C  C   . LYS A 1 60  ? -20.682 -14.305 14.752  1    44.61  ? 56  LYS A C   1 
ATOM   454  O  O   . LYS A 1 60  ? -21.652 -14.677 15.412  1    50.11  ? 56  LYS A O   1 
ATOM   455  C  CB  . LYS A 1 60  ? -19.802 -12.029 15.174  1    36.04  ? 56  LYS A CB  1 
ATOM   456  C  CG  . LYS A 1 60  ? -19.298 -11.12  16.255  1    36.19  ? 56  LYS A CG  1 
ATOM   457  C  CD  . LYS A 1 60  ? -20.141 -9.858  16.351  1    44.45  ? 56  LYS A CD  1 
ATOM   458  C  CE  . LYS A 1 60  ? -21.385 -9.959  17.187  1    43.43  ? 56  LYS A CE  1 
ATOM   459  N  NZ  . LYS A 1 60  ? -21.984 -8.619  17.298  1    43.33  ? 56  LYS A NZ  1 
ATOM   460  N  N   . GLU A 1 61  ? -20.503 -14.56  13.444  1    42.07  ? 57  GLU A N   1 
ATOM   461  C  CA  . GLU A 1 61  ? -21.519 -15.113 12.559  1    50.91  ? 57  GLU A CA  1 
ATOM   462  C  C   . GLU A 1 61  ? -21.376 -16.63  12.322  1    48.76  ? 57  GLU A C   1 
ATOM   463  O  O   . GLU A 1 61  ? -22.145 -17.218 11.562  1    59.69  ? 57  GLU A O   1 
ATOM   464  C  CB  . GLU A 1 61  ? -21.549 -14.293 11.261  1    59.94  ? 57  GLU A CB  1 
ATOM   465  C  CG  . GLU A 1 61  ? -22.59  -13.162 11.289  1    90.3   ? 57  GLU A CG  1 
ATOM   466  C  CD  . GLU A 1 61  ? -24.051 -13.398 11.744  1    86.01  ? 57  GLU A CD  1 
ATOM   467  O  OE1 . GLU A 1 61  ? -24.788 -14.26  11.162  1    62.26  ? 57  GLU A OE1 1 
ATOM   468  O  OE2 . GLU A 1 61  ? -24.445 -12.712 12.733  1    74.34  ? 57  GLU A OE2 1 
ATOM   469  N  N   . LEU A 1 62  ? -20.404 -17.283 12.946  1    35.5   ? 58  LEU A N   1 
ATOM   470  C  CA  . LEU A 1 62  ? -20.254 -18.708 12.735  1    34.27  ? 58  LEU A CA  1 
ATOM   471  C  C   . LEU A 1 62  ? -20.688 -19.437 14.002  1    33.21  ? 58  LEU A C   1 
ATOM   472  O  O   . LEU A 1 62  ? -19.855 -19.777 14.817  1    38.8   ? 58  LEU A O   1 
ATOM   473  C  CB  . LEU A 1 62  ? -18.804 -19.051 12.375  1    31.09  ? 58  LEU A CB  1 
ATOM   474  C  CG  . LEU A 1 62  ? -18.242 -18.381 11.115  1    33.95  ? 58  LEU A CG  1 
ATOM   475  C  CD1 . LEU A 1 62  ? -16.768 -18.599 11.011  1    31.69  ? 58  LEU A CD1 1 
ATOM   476  C  CD2 . LEU A 1 62  ? -18.92  -18.868 9.814   1    33.92  ? 58  LEU A CD2 1 
ATOM   477  N  N   A ASN A 1 63  ? -21.981 -19.695 14.149  0.5  32.37  ? 59  ASN A N   1 
ATOM   478  N  N   B ASN A 1 63  ? -21.992 -19.653 14.18   0.5  33.05  ? 59  ASN A N   1 
ATOM   479  C  CA  A ASN A 1 63  ? -22.443 -20.434 15.313  0.5  34.69  ? 59  ASN A CA  1 
ATOM   480  C  CA  B ASN A 1 63  ? -22.465 -20.448 15.309  0.5  35.74  ? 59  ASN A CA  1 
ATOM   481  C  C   A ASN A 1 63  ? -22.648 -21.894 14.897  0.5  35.14  ? 59  ASN A C   1 
ATOM   482  C  C   B ASN A 1 63  ? -22.612 -21.897 14.845  0.5  35.7   ? 59  ASN A C   1 
ATOM   483  O  O   A ASN A 1 63  ? -23.523 -22.217 14.094  0.5  38.94  ? 59  ASN A O   1 
ATOM   484  O  O   B ASN A 1 63  ? -23.428 -22.217 13.979  0.5  39.16  ? 59  ASN A O   1 
ATOM   485  C  CB  A ASN A 1 63  ? -23.589 -19.701 16.019  0.5  32.97  ? 59  ASN A CB  1 
ATOM   486  C  CB  B ASN A 1 63  ? -23.755 -19.904 15.933  0.5  34.95  ? 59  ASN A CB  1 
ATOM   487  C  CG  A ASN A 1 63  ? -23.189 -18.304 16.459  0.5  38.13  ? 59  ASN A CG  1 
ATOM   488  C  CG  B ASN A 1 63  ? -23.967 -20.371 17.358  0.5  41.24  ? 59  ASN A CG  1 
ATOM   489  O  OD1 A ASN A 1 63  ? -23.841 -17.32  16.096  0.5  38.33  ? 59  ASN A OD1 1 
ATOM   490  O  OD1 B ASN A 1 63  ? -23.067 -20.946 17.983  0.5  48     ? 59  ASN A OD1 1 
ATOM   491  N  ND2 A ASN A 1 63  ? -22.12  -18.177 17.24   0.5  36.26  ? 59  ASN A ND2 1 
ATOM   492  N  ND2 B ASN A 1 63  ? -25.141 -20.109 17.911  0.5  43.28  ? 59  ASN A ND2 1 
ATOM   493  N  N   . HIS A 1 64  ? -21.794 -22.777 15.416  1    32.68  ? 60  HIS A N   1 
ATOM   494  C  CA  . HIS A 1 64  ? -21.789 -24.169 15.007  1    30.07  ? 60  HIS A CA  1 
ATOM   495  C  C   . HIS A 1 64  ? -21.007 -24.992 16.029  1    31.46  ? 60  HIS A C   1 
ATOM   496  O  O   . HIS A 1 64  ? -19.977 -24.574 16.569  1    30.74  ? 60  HIS A O   1 
ATOM   497  C  CB  . HIS A 1 64  ? -21.141 -24.287 13.617  1    28.2   ? 60  HIS A CB  1 
ATOM   498  C  CG  . HIS A 1 64  ? -21.207 -25.675 13.087  1    29.98  ? 60  HIS A CG  1 
ATOM   499  N  ND1 . HIS A 1 64  ? -20.403 -26.711 13.538  1    31.25  ? 60  HIS A ND1 1 
ATOM   500  C  CD2 . HIS A 1 64  ? -22.017 -26.189 12.142  1    26.93  ? 60  HIS A CD2 1 
ATOM   501  C  CE1 . HIS A 1 64  ? -20.708 -27.806 12.86   1    33.55  ? 60  HIS A CE1 1 
ATOM   502  N  NE2 . HIS A 1 64  ? -21.691 -27.504 12.017  1    29.95  ? 60  HIS A NE2 1 
ATOM   503  N  N   . PRO A 1 65  ? -21.439 -26.229 16.301  1    32.58  ? 61  PRO A N   1 
ATOM   504  C  CA  . PRO A 1 65  ? -20.814 -27.008 17.377  1    30.99  ? 61  PRO A CA  1 
ATOM   505  C  C   . PRO A 1 65  ? -19.339 -27.367 17.178  1    30.7   ? 61  PRO A C   1 
ATOM   506  O  O   . PRO A 1 65  ? -18.675 -27.715 18.152  1    32.55  ? 61  PRO A O   1 
ATOM   507  C  CB  . PRO A 1 65  ? -21.694 -28.256 17.451  1    26.36  ? 61  PRO A CB  1 
ATOM   508  C  CG  . PRO A 1 65  ? -22.93  -27.921 16.661  1    29.32  ? 61  PRO A CG  1 
ATOM   509  C  CD  . PRO A 1 65  ? -22.533 -26.917 15.606  1    28.04  ? 61  PRO A CD  1 
ATOM   510  N  N   . ASN A 1 66  ? -18.854 -27.33  15.928  1    25.78  ? 62  ASN A N   1 
ATOM   511  C  CA  . ASN A 1 66  ? -17.458 -27.624 15.645  1    28.21  ? 62  ASN A CA  1 
ATOM   512  C  C   . ASN A 1 66  ? -16.689 -26.367 15.241  1    30.41  ? 62  ASN A C   1 
ATOM   513  O  O   . ASN A 1 66  ? -15.667 -26.447 14.567  1    36.74  ? 62  ASN A O   1 
ATOM   514  C  CB  . ASN A 1 66  ? -17.357 -28.724 14.602  1    28.59  ? 62  ASN A CB  1 
ATOM   515  C  CG  . ASN A 1 66  ? -18.181 -29.92  15.027  1    30.23  ? 62  ASN A CG  1 
ATOM   516  O  OD1 . ASN A 1 66  ? -19.198 -30.232 14.406  1    28.29  ? 62  ASN A OD1 1 
ATOM   517  N  ND2 . ASN A 1 66  ? -17.797 -30.569 16.114  1    25.05  ? 62  ASN A ND2 1 
ATOM   518  N  N   . ILE A 1 67  ? -17.205 -25.196 15.61   1    29.7   ? 63  ILE A N   1 
ATOM   519  C  CA  . ILE A 1 67  ? -16.433 -23.976 15.536  1    28.38  ? 63  ILE A CA  1 
ATOM   520  C  C   . ILE A 1 67  ? -16.49  -23.406 16.942  1    28.84  ? 63  ILE A C   1 
ATOM   521  O  O   . ILE A 1 67  ? -17.574 -23.236 17.48   1    39.25  ? 63  ILE A O   1 
ATOM   522  C  CB  . ILE A 1 67  ? -17.03  -23.01  14.498  1    31.05  ? 63  ILE A CB  1 
ATOM   523  C  CG1 . ILE A 1 67  ? -17.06  -23.629 13.091  1    30.62  ? 63  ILE A CG1 1 
ATOM   524  C  CG2 . ILE A 1 67  ? -16.286 -21.676 14.487  1    31.45  ? 63  ILE A CG2 1 
ATOM   525  C  CD1 . ILE A 1 67  ? -17.913 -22.873 12.086  1    27.7   ? 63  ILE A CD1 1 
ATOM   526  N  N   . VAL A 1 68  ? -15.333 -23.238 17.572  1    28.81  ? 64  VAL A N   1 
ATOM   527  C  CA  . VAL A 1 68  ? -15.186 -22.57  18.862  1    26.3   ? 64  VAL A CA  1 
ATOM   528  C  C   . VAL A 1 68  ? -16.016 -21.289 18.88   1    25.82  ? 64  VAL A C   1 
ATOM   529  O  O   . VAL A 1 68  ? -16.023 -20.514 17.938  1    28.53  ? 64  VAL A O   1 
ATOM   530  C  CB  . VAL A 1 68  ? -13.705 -22.219 19.139  1    27.44  ? 64  VAL A CB  1 
ATOM   531  C  CG1 . VAL A 1 68  ? -13.178 -21.157 18.132  1    25.63  ? 64  VAL A CG1 1 
ATOM   532  C  CG2 . VAL A 1 68  ? -13.467 -21.813 20.59   1    25.03  ? 64  VAL A CG2 1 
ATOM   533  N  N   . LYS A 1 69  ? -16.641 -21.019 20.024  1    28.04  ? 65  LYS A N   1 
ATOM   534  C  CA  . LYS A 1 69  ? -17.56  -19.915 20.15   1    28.12  ? 65  LYS A CA  1 
ATOM   535  C  C   . LYS A 1 69  ? -16.876 -18.698 20.774  1    28.71  ? 65  LYS A C   1 
ATOM   536  O  O   . LYS A 1 69  ? -16.304 -18.793 21.872  1    32.54  ? 65  LYS A O   1 
ATOM   537  C  CB  . LYS A 1 69  ? -18.746 -20.45  20.964  1    31.15  ? 65  LYS A CB  1 
ATOM   538  C  CG  . LYS A 1 69  ? -19.739 -19.378 21.389  1    48.51  ? 65  LYS A CG  1 
ATOM   539  C  CD  . LYS A 1 69  ? -20.787 -18.997 20.354  1    65.37  ? 65  LYS A CD  1 
ATOM   540  C  CE  . LYS A 1 69  ? -22.14  -18.992 21.003  1    78.17  ? 65  LYS A CE  1 
ATOM   541  N  NZ  . LYS A 1 69  ? -23.015 -17.957 20.451  1    95.89  ? 65  LYS A NZ  1 
ATOM   542  N  N   . LEU A 1 70  ? -17.003 -17.554 20.079  1    26.78  ? 66  LEU A N   1 
ATOM   543  C  CA  . LEU A 1 70  ? -16.723 -16.236 20.621  1    23.51  ? 66  LEU A CA  1 
ATOM   544  C  C   . LEU A 1 70  ? -17.934 -15.858 21.451  1    25.24  ? 66  LEU A C   1 
ATOM   545  O  O   . LEU A 1 70  ? -19.02  -15.732 20.896  1    29.27  ? 66  LEU A O   1 
ATOM   546  C  CB  . LEU A 1 70  ? -16.512 -15.216 19.512  1    22.17  ? 66  LEU A CB  1 
ATOM   547  C  CG  . LEU A 1 70  ? -15.934 -13.875 19.969  1    22.17  ? 66  LEU A CG  1 
ATOM   548  C  CD1 . LEU A 1 70  ? -14.65  -14.101 20.766  1    23.27  ? 66  LEU A CD1 1 
ATOM   549  C  CD2 . LEU A 1 70  ? -15.702 -12.994 18.757  1    21.7   ? 66  LEU A CD2 1 
ATOM   550  N  N   . LEU A 1 71  ? -17.739 -15.759 22.768  1    23.49  ? 67  LEU A N   1 
ATOM   551  C  CA  . LEU A 1 71  ? -18.833 -15.525 23.689  1    21.77  ? 67  LEU A CA  1 
ATOM   552  C  C   . LEU A 1 71  ? -19.038 -14.038 23.882  1    20.4   ? 67  LEU A C   1 
ATOM   553  O  O   . LEU A 1 71  ? -20.151 -13.625 24.183  1    19.18  ? 67  LEU A O   1 
ATOM   554  C  CB  . LEU A 1 71  ? -18.542 -16.204 25.027  1    24.47  ? 67  LEU A CB  1 
ATOM   555  C  CG  . LEU A 1 71  ? -18.353 -17.728 24.953  1    29     ? 67  LEU A CG  1 
ATOM   556  C  CD1 . LEU A 1 71  ? -17.904 -18.287 26.327  1    22.47  ? 67  LEU A CD1 1 
ATOM   557  C  CD2 . LEU A 1 71  ? -19.649 -18.371 24.443  1    23.71  ? 67  LEU A CD2 1 
ATOM   558  N  N   . ASP A 1 72  ? -17.946 -13.268 23.771  1    20.29  ? 68  ASP A N   1 
ATOM   559  C  CA  . ASP A 1 72  ? -17.999 -11.849 24.061  1    19.88  ? 68  ASP A CA  1 
ATOM   560  C  C   . ASP A 1 72  ? -16.74  -11.128 23.591  1    20.45  ? 68  ASP A C   1 
ATOM   561  O  O   . ASP A 1 72  ? -15.731 -11.753 23.273  1    24     ? 68  ASP A O   1 
ATOM   562  C  CB  . ASP A 1 72  ? -18.218 -11.611 25.539  1    20.02  ? 68  ASP A CB  1 
ATOM   563  C  CG  . ASP A 1 72  ? -18.992 -10.336 25.831  1    23.81  ? 68  ASP A CG  1 
ATOM   564  O  OD1 . ASP A 1 72  ? -19.428 -9.647  24.862  1    25.55  ? 68  ASP A OD1 1 
ATOM   565  O  OD2 . ASP A 1 72  ? -19.148 -10.039 27.017  1    25.57  ? 68  ASP A OD2 1 
ATOM   566  N  N   . VAL A 1 73  ? -16.816 -9.802  23.545  1    18.12  ? 69  VAL A N   1 
ATOM   567  C  CA  . VAL A 1 73  ? -15.661 -8.977  23.288  1    19.87  ? 69  VAL A CA  1 
ATOM   568  C  C   . VAL A 1 73  ? -15.765 -7.786  24.227  1    22.52  ? 69  VAL A C   1 
ATOM   569  O  O   . VAL A 1 73  ? -16.771 -7.078  24.199  1    26.28  ? 69  VAL A O   1 
ATOM   570  C  CB  . VAL A 1 73  ? -15.611 -8.54   21.81   1    20.16  ? 69  VAL A CB  1 
ATOM   571  C  CG1 . VAL A 1 73  ? -14.474 -7.552  21.542  1    18.77  ? 69  VAL A CG1 1 
ATOM   572  C  CG2 . VAL A 1 73  ? -15.562 -9.738  20.866  1    17.82  ? 69  VAL A CG2 1 
ATOM   573  N  N   . ILE A 1 74  ? -14.744 -7.588  25.076  1    23.93  ? 70  ILE A N   1 
ATOM   574  C  CA  . ILE A 1 74  ? -14.73  -6.486  26.028  1    25.86  ? 70  ILE A CA  1 
ATOM   575  C  C   . ILE A 1 74  ? -13.623 -5.505  25.651  1    29.61  ? 70  ILE A C   1 
ATOM   576  O  O   . ILE A 1 74  ? -12.489 -5.925  25.43   1    31.03  ? 70  ILE A O   1 
ATOM   577  C  CB  . ILE A 1 74  ? -14.538 -7.021  27.465  1    27.76  ? 70  ILE A CB  1 
ATOM   578  C  CG1 . ILE A 1 74  ? -15.804 -7.642  28.031  1    27.25  ? 70  ILE A CG1 1 
ATOM   579  C  CG2 . ILE A 1 74  ? -14.01  -5.947  28.416  1    24.57  ? 70  ILE A CG2 1 
ATOM   580  C  CD1 . ILE A 1 74  ? -15.726 -9.137  28.251  1    25.42  ? 70  ILE A CD1 1 
ATOM   581  N  N   A HIS A 1 75  ? -13.964 -4.209  25.537  0.5  35.94  ? 71  HIS A N   1 
ATOM   582  N  N   B HIS A 1 75  ? -13.968 -4.213  25.623  0.5  35.29  ? 71  HIS A N   1 
ATOM   583  C  CA  A HIS A 1 75  ? -12.939 -3.176  25.411  0.5  41.06  ? 71  HIS A CA  1 
ATOM   584  C  CA  B HIS A 1 75  ? -13.009 -3.145  25.384  0.5  39.78  ? 71  HIS A CA  1 
ATOM   585  C  C   A HIS A 1 75  ? -12.754 -2.46   26.738  0.5  46.24  ? 71  HIS A C   1 
ATOM   586  C  C   B HIS A 1 75  ? -12.736 -2.427  26.706  0.5  45.34  ? 71  HIS A C   1 
ATOM   587  O  O   A HIS A 1 75  ? -13.476 -1.515  27.034  0.5  47.82  ? 71  HIS A O   1 
ATOM   588  O  O   B HIS A 1 75  ? -13.425 -1.457  27      0.5  46.84  ? 71  HIS A O   1 
ATOM   589  C  CB  A HIS A 1 75  ? -13.28  -1.99   24.499  0.5  37.53  ? 71  HIS A CB  1 
ATOM   590  C  CB  B HIS A 1 75  ? -13.59  -2.108  24.407  0.5  35.56  ? 71  HIS A CB  1 
ATOM   591  C  CG  A HIS A 1 75  ? -12.09  -1.058  24.418  0.5  36.88  ? 71  HIS A CG  1 
ATOM   592  C  CG  B HIS A 1 75  ? -14.448 -2.604  23.266  0.5  34.21  ? 71  HIS A CG  1 
ATOM   593  N  ND1 A HIS A 1 75  ? -12.052 0.269   24.793  0.5  39.7   ? 71  HIS A ND1 1 
ATOM   594  N  ND1 B HIS A 1 75  ? -14.289 -2.174  21.96   0.5  33.62  ? 71  HIS A ND1 1 
ATOM   595  C  CD2 A HIS A 1 75  ? -10.832 -1.334  24.042  0.5  37.5   ? 71  HIS A CD2 1 
ATOM   596  C  CD2 B HIS A 1 75  ? -15.484 -3.454  23.233  0.5  32.44  ? 71  HIS A CD2 1 
ATOM   597  C  CE1 A HIS A 1 75  ? -10.832 0.767   24.611  0.5  36.65  ? 71  HIS A CE1 1 
ATOM   598  C  CE1 B HIS A 1 75  ? -15.19  -2.753  21.177  0.5  32.01  ? 71  HIS A CE1 1 
ATOM   599  N  NE2 A HIS A 1 75  ? -10.076 -0.199  24.156  0.5  35.89  ? 71  HIS A NE2 1 
ATOM   600  N  NE2 B HIS A 1 75  ? -15.923 -3.537  21.927  0.5  31.36  ? 71  HIS A NE2 1 
ATOM   601  N  N   . THR A 1 76  ? -11.755 -2.882  27.507  1    53.4   ? 72  THR A N   1 
ATOM   602  C  CA  . THR A 1 76  ? -11.393 -2.151  28.727  1    56.9   ? 72  THR A CA  1 
ATOM   603  C  C   . THR A 1 76  ? -10.617 -0.907  28.307  1    69.62  ? 72  THR A C   1 
ATOM   604  O  O   . THR A 1 76  ? -10.827 -0.358  27.23   1    71.92  ? 72  THR A O   1 
ATOM   605  C  CB  . THR A 1 76  ? -10.598 -2.947  29.767  1    56.74  ? 72  THR A CB  1 
ATOM   606  O  OG1 . THR A 1 76  ? -9.275  -3.039  29.236  1    71.1   ? 72  THR A OG1 1 
ATOM   607  C  CG2 . THR A 1 76  ? -11.16  -4.326  30.057  1    62.84  ? 72  THR A CG2 1 
ATOM   608  N  N   . GLU A 1 77  ? -9.675  -0.483  29.141  1    80.81  ? 73  GLU A N   1 
ATOM   609  C  CA  . GLU A 1 77  ? -9.033  0.791   28.883  1    84.38  ? 73  GLU A CA  1 
ATOM   610  C  C   . GLU A 1 77  ? -7.68   0.477   28.249  1    73.82  ? 73  GLU A C   1 
ATOM   611  O  O   . GLU A 1 77  ? -6.78   -0.019  28.937  1    78.39  ? 73  GLU A O   1 
ATOM   612  C  CB  . GLU A 1 77  ? -9.029  1.614   30.177  1    95.23  ? 73  GLU A CB  1 
ATOM   613  C  CG  . GLU A 1 77  ? -10.148 1.263   31.157  1    99.16  ? 73  GLU A CG  1 
ATOM   614  C  CD  . GLU A 1 77  ? -11.588 1.101   30.683  1    99.55  ? 73  GLU A CD  1 
ATOM   615  O  OE1 . GLU A 1 77  ? -12.027 1.963   29.905  1    96.87  ? 73  GLU A OE1 1 
ATOM   616  O  OE2 . GLU A 1 77  ? -12.287 0.153   31.106  1    103.46 ? 73  GLU A OE2 1 
ATOM   617  N  N   . ASN A 1 78  ? -7.577  0.729   26.931  1    59.61  ? 74  ASN A N   1 
ATOM   618  C  CA  . ASN A 1 78  ? -6.363  0.477   26.168  1    57.43  ? 74  ASN A CA  1 
ATOM   619  C  C   . ASN A 1 78  ? -6.252  -1.01   25.803  1    46.97  ? 74  ASN A C   1 
ATOM   620  O  O   . ASN A 1 78  ? -5.24   -1.43   25.241  1    39.92  ? 74  ASN A O   1 
ATOM   621  C  CB  . ASN A 1 78  ? -5.121  0.988   26.907  1    59.45  ? 74  ASN A CB  1 
ATOM   622  C  CG  . ASN A 1 78  ? -4.845  2.467   26.745  1    58.68  ? 74  ASN A CG  1 
ATOM   623  O  OD1 . ASN A 1 78  ? -5.262  3.273   27.582  1    61.15  ? 74  ASN A OD1 1 
ATOM   624  N  ND2 . ASN A 1 78  ? -4.098  2.846   25.717  1    59.48  ? 74  ASN A ND2 1 
ATOM   625  N  N   . LYS A 1 79  ? -7.291  -1.803  26.121  1    45.75  ? 75  LYS A N   1 
ATOM   626  C  CA  . LYS A 1 79  ? -7.232  -3.251  25.967  1    39.93  ? 75  LYS A CA  1 
ATOM   627  C  C   . LYS A 1 79  ? -8.515  -3.814  25.357  1    33.41  ? 75  LYS A C   1 
ATOM   628  O  O   . LYS A 1 79  ? -9.603  -3.254  25.509  1    30.44  ? 75  LYS A O   1 
ATOM   629  C  CB  . LYS A 1 79  ? -6.925  -3.911  27.312  1    46.45  ? 75  LYS A CB  1 
ATOM   630  C  CG  . LYS A 1 79  ? -5.555  -3.662  27.912  1    55.62  ? 75  LYS A CG  1 
ATOM   631  C  CD  . LYS A 1 79  ? -5.344  -4.343  29.272  1    68.06  ? 75  LYS A CD  1 
ATOM   632  C  CE  . LYS A 1 79  ? -3.983  -4.158  29.927  1    74.97  ? 75  LYS A CE  1 
ATOM   633  N  NZ  . LYS A 1 79  ? -3.886  -4.829  31.239  1    87.9   ? 75  LYS A NZ  1 
ATOM   634  N  N   . LEU A 1 80  ? -8.353  -4.96   24.685  1    29.44  ? 76  LEU A N   1 
ATOM   635  C  CA  . LEU A 1 80  ? -9.429  -5.657  24.004  1    27.55  ? 76  LEU A CA  1 
ATOM   636  C  C   . LEU A 1 80  ? -9.344  -7.153  24.308  1    27.59  ? 76  LEU A C   1 
ATOM   637  O  O   . LEU A 1 80  ? -8.393  -7.812  23.889  1    26.11  ? 76  LEU A O   1 
ATOM   638  C  CB  . LEU A 1 80  ? -9.296  -5.397  22.5    1    29.21  ? 76  LEU A CB  1 
ATOM   639  C  CG  . LEU A 1 80  ? -10.527 -5.716  21.639  1    27.92  ? 76  LEU A CG  1 
ATOM   640  C  CD1 . LEU A 1 80  ? -11.553 -4.587  21.862  1    31.82  ? 76  LEU A CD1 1 
ATOM   641  C  CD2 . LEU A 1 80  ? -10.14  -5.808  20.195  1    24.31  ? 76  LEU A CD2 1 
ATOM   642  N  N   . TYR A 1 81  ? -10.367 -7.689  25      1    28.95  ? 77  TYR A N   1 
ATOM   643  C  CA  . TYR A 1 81  ? -10.4   -9.074  25.463  1    26.7   ? 77  TYR A CA  1 
ATOM   644  C  C   . TYR A 1 81  ? -11.439 -9.884  24.686  1    26.33  ? 77  TYR A C   1 
ATOM   645  O  O   . TYR A 1 81  ? -12.624 -9.566  24.719  1    27.35  ? 77  TYR A O   1 
ATOM   646  C  CB  . TYR A 1 81  ? -10.808 -9.091  26.937  1    28.72  ? 77  TYR A CB  1 
ATOM   647  C  CG  . TYR A 1 81  ? -9.755  -8.634  27.932  1    33.24  ? 77  TYR A CG  1 
ATOM   648  C  CD1 . TYR A 1 81  ? -8.755  -9.505  28.363  1    35.27  ? 77  TYR A CD1 1 
ATOM   649  C  CD2 . TYR A 1 81  ? -9.767  -7.34   28.457  1    34.46  ? 77  TYR A CD2 1 
ATOM   650  C  CE1 . TYR A 1 81  ? -7.787  -9.098  29.276  1    36.93  ? 77  TYR A CE1 1 
ATOM   651  C  CE2 . TYR A 1 81  ? -8.811  -6.939  29.384  1    36.86  ? 77  TYR A CE2 1 
ATOM   652  C  CZ  . TYR A 1 81  ? -7.811  -7.812  29.796  1    38.21  ? 77  TYR A CZ  1 
ATOM   653  O  OH  . TYR A 1 81  ? -6.878  -7.4    30.725  1    43.51  ? 77  TYR A OH  1 
ATOM   654  N  N   . LEU A 1 82  ? -11     -10.949 24.013  1    23.89  ? 78  LEU A N   1 
ATOM   655  C  CA  . LEU A 1 82  ? -11.901 -11.882 23.355  1    25.24  ? 78  LEU A CA  1 
ATOM   656  C  C   . LEU A 1 82  ? -12.241 -13.013 24.317  1    27.39  ? 78  LEU A C   1 
ATOM   657  O  O   . LEU A 1 82  ? -11.338 -13.702 24.76   1    32.19  ? 78  LEU A O   1 
ATOM   658  C  CB  . LEU A 1 82  ? -11.319 -12.498 22.081  1    23.37  ? 78  LEU A CB  1 
ATOM   659  C  CG  . LEU A 1 82  ? -11.037 -11.565 20.901  1    23.43  ? 78  LEU A CG  1 
ATOM   660  C  CD1 . LEU A 1 82  ? -10.334 -12.376 19.829  1    22.04  ? 78  LEU A CD1 1 
ATOM   661  C  CD2 . LEU A 1 82  ? -12.258 -10.906 20.37   1    23.68  ? 78  LEU A CD2 1 
ATOM   662  N  N   . VAL A 1 83  ? -13.535 -13.239 24.588  1    26.23  ? 79  VAL A N   1 
ATOM   663  C  CA  . VAL A 1 83  ? -13.944 -14.312 25.484  1    23     ? 79  VAL A CA  1 
ATOM   664  C  C   . VAL A 1 83  ? -14.41  -15.506 24.664  1    26.48  ? 79  VAL A C   1 
ATOM   665  O  O   . VAL A 1 83  ? -15.376 -15.431 23.901  1    28.89  ? 79  VAL A O   1 
ATOM   666  C  CB  . VAL A 1 83  ? -15.066 -13.85  26.413  1    20.39  ? 79  VAL A CB  1 
ATOM   667  C  CG1 . VAL A 1 83  ? -15.364 -14.899 27.468  1    19.57  ? 79  VAL A CG1 1 
ATOM   668  C  CG2 . VAL A 1 83  ? -14.692 -12.523 27.048  1    19.12  ? 79  VAL A CG2 1 
ATOM   669  N  N   . PHE A 1 84  ? -13.712 -16.616 24.828  1    25.01  ? 80  PHE A N   1 
ATOM   670  C  CA  . PHE A 1 84  ? -14.053 -17.804 24.026  1    24.7   ? 80  PHE A CA  1 
ATOM   671  C  C   . PHE A 1 84  ? -14.488 -18.91  24.941  1    25.52  ? 80  PHE A C   1 
ATOM   672  O  O   . PHE A 1 84  ? -14.166 -18.888 26.128  1    30.92  ? 80  PHE A O   1 
ATOM   673  C  CB  . PHE A 1 84  ? -12.814 -18.275 23.268  1    22.56  ? 80  PHE A CB  1 
ATOM   674  C  CG  . PHE A 1 84  ? -12.288 -17.44  22.114  1    21.57  ? 80  PHE A CG  1 
ATOM   675  C  CD1 . PHE A 1 84  ? -11.323 -16.465 22.324  1    21.07  ? 80  PHE A CD1 1 
ATOM   676  C  CD2 . PHE A 1 84  ? -12.714 -17.678 20.815  1    22     ? 80  PHE A CD2 1 
ATOM   677  C  CE1 . PHE A 1 84  ? -10.825 -15.73  21.265  1    22.5   ? 80  PHE A CE1 1 
ATOM   678  C  CE2 . PHE A 1 84  ? -12.213 -16.935 19.764  1    20.18  ? 80  PHE A CE2 1 
ATOM   679  C  CZ  . PHE A 1 84  ? -11.273 -15.963 19.989  1    19.42  ? 80  PHE A CZ  1 
ATOM   680  N  N   . GLU A 1 85  ? -15.212 -19.872 24.39   1    27.19  ? 81  GLU A N   1 
ATOM   681  C  CA  . GLU A 1 85  ? -15.564 -21.06  25.184  1    27.05  ? 81  GLU A CA  1 
ATOM   682  C  C   . GLU A 1 85  ? -14.261 -21.787 25.512  1    30.02  ? 81  GLU A C   1 
ATOM   683  O  O   . GLU A 1 85  ? -13.274 -21.628 24.774  1    35.52  ? 81  GLU A O   1 
ATOM   684  C  CB  . GLU A 1 85  ? -16.515 -21.945 24.387  1    28.82  ? 81  GLU A CB  1 
ATOM   685  C  CG  . GLU A 1 85  ? -15.862 -22.648 23.205  1    30.48  ? 81  GLU A CG  1 
ATOM   686  C  CD  . GLU A 1 85  ? -16.764 -23.684 22.572  1    30.98  ? 81  GLU A CD  1 
ATOM   687  O  OE1 . GLU A 1 85  ? -17.233 -24.591 23.282  1    31.12  ? 81  GLU A OE1 1 
ATOM   688  O  OE2 . GLU A 1 85  ? -17.001 -23.572 21.361  1    25.42  ? 81  GLU A OE2 1 
ATOM   689  N  N   . PHE A 1 86  ? -14.269 -22.578 26.573  1    30.73  ? 82  PHE A N   1 
ATOM   690  C  CA  . PHE A 1 86  ? -13.007 -23.231 26.987  1    27.42  ? 82  PHE A CA  1 
ATOM   691  C  C   . PHE A 1 86  ? -12.961 -24.685 26.601  1    26.2   ? 82  PHE A C   1 
ATOM   692  O  O   . PHE A 1 86  ? -13.877 -25.438 26.954  1    28.51  ? 82  PHE A O   1 
ATOM   693  C  CB  . PHE A 1 86  ? -12.736 -23.153 28.49   1    31.13  ? 82  PHE A CB  1 
ATOM   694  C  CG  . PHE A 1 86  ? -11.465 -23.867 28.923  1    35.46  ? 82  PHE A CG  1 
ATOM   695  C  CD1 . PHE A 1 86  ? -10.219 -23.302 28.686  1    30.88  ? 82  PHE A CD1 1 
ATOM   696  C  CD2 . PHE A 1 86  ? -11.518 -25.105 29.551  1    36.62  ? 82  PHE A CD2 1 
ATOM   697  C  CE1 . PHE A 1 86  ? -9.064  -23.959 29.07   1    30.88  ? 82  PHE A CE1 1 
ATOM   698  C  CE2 . PHE A 1 86  ? -10.36  -25.755 29.932  1    31.42  ? 82  PHE A CE2 1 
ATOM   699  C  CZ  . PHE A 1 86  ? -9.137  -25.18  29.692  1    30.46  ? 82  PHE A CZ  1 
ATOM   700  N  N   . LEU A 1 87  ? -11.938 -25.058 25.849  1    24.47  ? 83  LEU A N   1 
ATOM   701  C  CA  . LEU A 1 87  ? -11.63  -26.449 25.556  1    27.27  ? 83  LEU A CA  1 
ATOM   702  C  C   . LEU A 1 87  ? -10.248 -26.816 26.102  1    29     ? 83  LEU A C   1 
ATOM   703  O  O   . LEU A 1 87  ? -9.332  -25.995 26.069  1    29.33  ? 83  LEU A O   1 
ATOM   704  C  CB  . LEU A 1 87  ? -11.686 -26.681 24.058  1    25.84  ? 83  LEU A CB  1 
ATOM   705  C  CG  . LEU A 1 87  ? -13.091 -26.669 23.463  1    36.14  ? 83  LEU A CG  1 
ATOM   706  C  CD1 . LEU A 1 87  ? -13.426 -25.306 22.916  1    35.27  ? 83  LEU A CD1 1 
ATOM   707  C  CD2 . LEU A 1 87  ? -13.222 -27.754 22.384  1    39.31  ? 83  LEU A CD2 1 
ATOM   708  N  N   A HIS A 1 88  ? -10.096 -28.08  26.494  0.5  28.3   ? 84  HIS A N   1 
ATOM   709  N  N   B HIS A 1 88  ? -10.1   -28.073 26.556  0.5  27.86  ? 84  HIS A N   1 
ATOM   710  C  CA  A HIS A 1 88  ? -9.069  -28.478 27.439  0.5  29.53  ? 84  HIS A CA  1 
ATOM   711  C  CA  B HIS A 1 88  ? -9.024  -28.471 27.459  0.5  28.64  ? 84  HIS A CA  1 
ATOM   712  C  C   A HIS A 1 88  ? -7.714  -28.64  26.743  0.5  29.74  ? 84  HIS A C   1 
ATOM   713  C  C   B HIS A 1 88  ? -7.685  -28.618 26.734  0.5  29.19  ? 84  HIS A C   1 
ATOM   714  O  O   A HIS A 1 88  ? -6.676  -28.502 27.386  0.5  31.45  ? 84  HIS A O   1 
ATOM   715  O  O   B HIS A 1 88  ? -6.633  -28.467 27.352  0.5  30.75  ? 84  HIS A O   1 
ATOM   716  C  CB  A HIS A 1 88  ? -9.574  -29.679 28.252  0.5  28.73  ? 84  HIS A CB  1 
ATOM   717  C  CB  B HIS A 1 88  ? -9.41   -29.664 28.358  0.5  26.99  ? 84  HIS A CB  1 
ATOM   718  C  CG  A HIS A 1 88  ? -11.011 -29.547 28.679  0.5  28.08  ? 84  HIS A CG  1 
ATOM   719  C  CG  B HIS A 1 88  ? -9.131  -31.068 27.869  0.5  25.27  ? 84  HIS A CG  1 
ATOM   720  N  ND1 A HIS A 1 88  ? -12.082 -29.465 27.8    0.5  22.65  ? 84  HIS A ND1 1 
ATOM   721  N  ND1 B HIS A 1 88  ? -9.77   -31.689 26.815  0.5  24.95  ? 84  HIS A ND1 1 
ATOM   722  C  CD2 A HIS A 1 88  ? -11.523 -29.447 29.925  0.5  25.8   ? 84  HIS A CD2 1 
ATOM   723  C  CD2 B HIS A 1 88  ? -8.268  -31.985 28.351  0.5  25.07  ? 84  HIS A CD2 1 
ATOM   724  C  CE1 A HIS A 1 88  ? -13.196 -29.326 28.488  0.5  22.64  ? 84  HIS A CE1 1 
ATOM   725  C  CE1 B HIS A 1 88  ? -9.294  -32.927 26.668  0.5  26     ? 84  HIS A CE1 1 
ATOM   726  N  NE2 A HIS A 1 88  ? -12.88  -29.313 29.777  0.5  26.04  ? 84  HIS A NE2 1 
ATOM   727  N  NE2 B HIS A 1 88  ? -8.378  -33.129 27.59   0.5  25.32  ? 84  HIS A NE2 1 
ATOM   728  N  N   . GLN A 1 89  ? -7.719  -28.898 25.431  1    28.67  ? 85  GLN A N   1 
ATOM   729  C  CA  . GLN A 1 89  ? -6.492  -29.281 24.743  1    28.99  ? 85  GLN A CA  1 
ATOM   730  C  C   . GLN A 1 89  ? -6.649  -29.061 23.24   1    27.15  ? 85  GLN A C   1 
ATOM   731  O  O   . GLN A 1 89  ? -7.756  -28.88  22.763  1    29.51  ? 85  GLN A O   1 
ATOM   732  C  CB  . GLN A 1 89  ? -6.304  -30.73  25.2    1    31.26  ? 85  GLN A CB  1 
ATOM   733  C  CG  . GLN A 1 89  ? -5.344  -31.563 24.369  1    41.07  ? 85  GLN A CG  1 
ATOM   734  C  CD  . GLN A 1 89  ? -4.802  -32.674 25.225  1    57.29  ? 85  GLN A CD  1 
ATOM   735  O  OE1 . GLN A 1 89  ? -4.08   -32.41  26.182  1    80.73  ? 85  GLN A OE1 1 
ATOM   736  N  NE2 . GLN A 1 89  ? -5.175  -33.911 24.938  1    63.53  ? 85  GLN A NE2 1 
ATOM   737  N  N   . ASP A 1 90  ? -5.544  -29.036 22.494  1    29.07  ? 86  ASP A N   1 
ATOM   738  C  CA  . ASP A 1 90  ? -5.574  -29.023 21.032  1    29.94  ? 86  ASP A CA  1 
ATOM   739  C  C   . ASP A 1 90  ? -5.118  -30.392 20.497  1    29.71  ? 86  ASP A C   1 
ATOM   740  O  O   . ASP A 1 90  ? -4.491  -31.168 21.206  1    28     ? 86  ASP A O   1 
ATOM   741  C  CB  . ASP A 1 90  ? -4.691  -27.912 20.48   1    28.54  ? 86  ASP A CB  1 
ATOM   742  C  CG  . ASP A 1 90  ? -3.223  -28.205 20.702  1    32.6   ? 86  ASP A CG  1 
ATOM   743  O  OD1 . ASP A 1 90  ? -2.716  -29.1   20.032  1    37.34  ? 86  ASP A OD1 1 
ATOM   744  O  OD2 . ASP A 1 90  ? -2.626  -27.625 21.613  1    38.2   ? 86  ASP A OD2 1 
ATOM   745  N  N   . LEU A 1 91  ? -5.378  -30.666 19.215  1    30.1   ? 87  LEU A N   1 
ATOM   746  C  CA  . LEU A 1 91  ? -5.227  -32     18.661  1    30.04  ? 87  LEU A CA  1 
ATOM   747  C  C   . LEU A 1 91  ? -3.765  -32.427 18.693  1    35.07  ? 87  LEU A C   1 
ATOM   748  O  O   . LEU A 1 91  ? -3.488  -33.613 18.869  1    37.8   ? 87  LEU A O   1 
ATOM   749  C  CB  . LEU A 1 91  ? -5.763  -32.032 17.233  1    29.22  ? 87  LEU A CB  1 
ATOM   750  C  CG  . LEU A 1 91  ? -5.69   -33.391 16.527  1    28.08  ? 87  LEU A CG  1 
ATOM   751  C  CD1 . LEU A 1 91  ? -6.42   -34.454 17.348  1    23.61  ? 87  LEU A CD1 1 
ATOM   752  C  CD2 . LEU A 1 91  ? -6.217  -33.319 15.09   1    27.67  ? 87  LEU A CD2 1 
ATOM   753  N  N   . LYS A 1 92  ? -2.848  -31.472 18.492  1    35.14  ? 88  LYS A N   1 
ATOM   754  C  CA  . LYS A 1 92  ? -1.419  -31.752 18.461  1    35.2   ? 88  LYS A CA  1 
ATOM   755  C  C   . LYS A 1 92  ? -0.935  -32.28  19.82   1    40.39  ? 88  LYS A C   1 
ATOM   756  O  O   . LYS A 1 92  ? -0.206  -33.289 19.881  1    40.48  ? 88  LYS A O   1 
ATOM   757  C  CB  . LYS A 1 92  ? -0.688  -30.535 17.903  1    35.56  ? 88  LYS A CB  1 
ATOM   758  C  CG  . LYS A 1 92  ? 0.734   -30.352 18.353  1    41.28  ? 88  LYS A CG  1 
ATOM   759  C  CD  . LYS A 1 92  ? 1.663   -31.526 18.091  1    54.01  ? 88  LYS A CD  1 
ATOM   760  C  CE  . LYS A 1 92  ? 1.863   -31.86  16.655  1    64.18  ? 88  LYS A CE  1 
ATOM   761  N  NZ  . LYS A 1 92  ? 3.036   -32.74  16.572  1    62.78  ? 88  LYS A NZ  1 
ATOM   762  N  N   . LYS A 1 93  ? -1.367  -31.633 20.916  1    33.12  ? 89  LYS A N   1 
ATOM   763  C  CA  . LYS A 1 93  ? -0.994  -32.072 22.25   1    31.43  ? 89  LYS A CA  1 
ATOM   764  C  C   . LYS A 1 93  ? -1.525  -33.475 22.546  1    30.69  ? 89  LYS A C   1 
ATOM   765  O  O   . LYS A 1 93  ? -0.914  -34.2   23.304  1    35.01  ? 89  LYS A O   1 
ATOM   766  C  CB  . LYS A 1 93  ? -1.404  -31.034 23.291  1    35.59  ? 89  LYS A CB  1 
ATOM   767  C  CG  . LYS A 1 93  ? -0.334  -29.985 23.587  1    48.85  ? 89  LYS A CG  1 
ATOM   768  C  CD  . LYS A 1 93  ? -0.907  -28.65  24.051  1    58.73  ? 89  LYS A CD  1 
ATOM   769  C  CE  . LYS A 1 93  ? 0.163   -27.603 24.035  1    61.67  ? 89  LYS A CE  1 
ATOM   770  N  NZ  . LYS A 1 93  ? -0.23   -26.422 24.805  1    76.49  ? 89  LYS A NZ  1 
ATOM   771  N  N   . PHE A 1 94  ? -2.647  -33.87  21.929  1    28.84  ? 90  PHE A N   1 
ATOM   772  C  CA  . PHE A 1 94  ? -3.298  -35.14  22.199  1    27.63  ? 90  PHE A CA  1 
ATOM   773  C  C   . PHE A 1 94  ? -2.621  -36.267 21.429  1    28.73  ? 90  PHE A C   1 
ATOM   774  O  O   . PHE A 1 94  ? -2.474  -37.365 21.965  1    32.09  ? 90  PHE A O   1 
ATOM   775  C  CB  . PHE A 1 94  ? -4.806  -35     21.945  1    26.01  ? 90  PHE A CB  1 
ATOM   776  C  CG  . PHE A 1 94  ? -5.601  -36.298 21.924  1    26.79  ? 90  PHE A CG  1 
ATOM   777  C  CD1 . PHE A 1 94  ? -5.863  -37.002 23.095  1    27.86  ? 90  PHE A CD1 1 
ATOM   778  C  CD2 . PHE A 1 94  ? -6.093  -36.803 20.723  1    28.47  ? 90  PHE A CD2 1 
ATOM   779  C  CE1 . PHE A 1 94  ? -6.597  -38.179 23.075  1    26.6   ? 90  PHE A CE1 1 
ATOM   780  C  CE2 . PHE A 1 94  ? -6.846  -37.961 20.704  1    28.73  ? 90  PHE A CE2 1 
ATOM   781  C  CZ  . PHE A 1 94  ? -7.072  -38.655 21.878  1    31.02  ? 90  PHE A CZ  1 
ATOM   782  N  N   . MET A 1 95  ? -2.222  -35.99  20.198  1    31.56  ? 91  MET A N   1 
ATOM   783  C  CA  . MET A 1 95  ? -1.504  -37.008 19.397  1    38.18  ? 91  MET A CA  1 
ATOM   784  C  C   . MET A 1 95  ? -0.111  -37.208 19.994  1    42.45  ? 91  MET A C   1 
ATOM   785  O  O   . MET A 1 95  ? 0.422   -38.321 19.89   1    49.34  ? 91  MET A O   1 
ATOM   786  C  CB  . MET A 1 95  ? -1.359  -36.55  17.946  1    37.94  ? 91  MET A CB  1 
ATOM   787  C  CG  . MET A 1 95  ? -2.655  -36.432 17.184  1    35.93  ? 91  MET A CG  1 
ATOM   788  S  SD  . MET A 1 95  ? -2.365  -35.802 15.52   1    55.07  ? 91  MET A SD  1 
ATOM   789  C  CE  . MET A 1 95  ? -1.503  -34.272 15.892  1    41.02  ? 91  MET A CE  1 
ATOM   790  N  N   . ASP A 1 96  ? 0.435   -36.169 20.62   1    44.97  ? 92  ASP A N   1 
ATOM   791  C  CA  . ASP A 1 96  ? 1.818   -36.233 21.154  1    42.99  ? 92  ASP A CA  1 
ATOM   792  C  C   . ASP A 1 96  ? 1.834   -36.831 22.557  1    49.84  ? 92  ASP A C   1 
ATOM   793  O  O   . ASP A 1 96  ? 2.83    -37.486 22.894  1    64.38  ? 92  ASP A O   1 
ATOM   794  C  CB  . ASP A 1 96  ? 2.451   -34.854 21.2    1    37.62  ? 92  ASP A CB  1 
ATOM   795  C  CG  . ASP A 1 96  ? 3.034   -34.341 19.895  1    41.43  ? 92  ASP A CG  1 
ATOM   796  O  OD1 . ASP A 1 96  ? 2.889   -35.037 18.872  1    36.44  ? 92  ASP A OD1 1 
ATOM   797  O  OD2 . ASP A 1 96  ? 3.628   -33.249 19.922  1    40.15  ? 92  ASP A OD2 1 
ATOM   798  N  N   . ALA A 1 97  ? 0.768   -36.65  23.333  1    59.93  ? 93  ALA A N   1 
ATOM   799  C  CA  . ALA A 1 97  ? 0.822   -37.078 24.751  1    66.14  ? 93  ALA A CA  1 
ATOM   800  C  C   . ALA A 1 97  ? -0.057  -38.289 25.043  1    67.03  ? 93  ALA A C   1 
ATOM   801  O  O   . ALA A 1 97  ? 0.197   -38.972 26.051  1    67.75  ? 93  ALA A O   1 
ATOM   802  C  CB  . ALA A 1 97  ? 0.428   -35.92  25.628  1    58.79  ? 93  ALA A CB  1 
ATOM   803  N  N   . SER A 1 98  ? -1.059  -38.546 24.216  1    65.91  ? 94  SER A N   1 
ATOM   804  C  CA  . SER A 1 98  ? -1.991  -39.649 24.557  1    75.18  ? 94  SER A CA  1 
ATOM   805  C  C   . SER A 1 98  ? -2.218  -40.525 23.325  1    70.83  ? 94  SER A C   1 
ATOM   806  O  O   . SER A 1 98  ? -3.14   -41.361 23.351  1    82.1   ? 94  SER A O   1 
ATOM   807  C  CB  . SER A 1 98  ? -3.292  -39.121 25.104  1    85.94  ? 94  SER A CB  1 
ATOM   808  O  OG  . SER A 1 98  ? -4.233  -40.168 25.296  1    85.34  ? 94  SER A OG  1 
ATOM   809  N  N   . ALA A 1 99  ? -1.423  -40.327 22.284  1    57.42  ? 95  ALA A N   1 
ATOM   810  C  CA  . ALA A 1 99  ? -1.56   -41.241 21.136  1    69.08  ? 95  ALA A CA  1 
ATOM   811  C  C   . ALA A 1 99  ? -0.192  -41.865 20.877  1    69.85  ? 95  ALA A C   1 
ATOM   812  O  O   . ALA A 1 99  ? 0.412   -41.635 19.818  1    75.85  ? 95  ALA A O   1 
ATOM   813  C  CB  . ALA A 1 99  ? -2.129  -40.509 19.961  1    73.94  ? 95  ALA A CB  1 
ATOM   814  N  N   . LEU A 1 100 ? 0.293   -42.612 21.862  1    78.68  ? 96  LEU A N   1 
ATOM   815  C  CA  . LEU A 1 100 ? 1.603   -43.285 21.754  1    80.09  ? 96  LEU A CA  1 
ATOM   816  C  C   . LEU A 1 100 ? 1.373   -44.633 21.078  1    84.9   ? 96  LEU A C   1 
ATOM   817  O  O   . LEU A 1 100 ? 2.149   -44.975 20.168  1    78.31  ? 96  LEU A O   1 
ATOM   818  C  CB  . LEU A 1 100 ? 1.994   -43.421 23.217  1    84.22  ? 96  LEU A CB  1 
ATOM   819  C  CG  . LEU A 1 100 ? 2.233   -42.099 23.955  1    97.22  ? 96  LEU A CG  1 
ATOM   820  C  CD1 . LEU A 1 100 ? 2.475   -42.308 25.437  1    93.69  ? 96  LEU A CD1 1 
ATOM   821  C  CD2 . LEU A 1 100 ? 3.367   -41.301 23.334  1    88.85  ? 96  LEU A CD2 1 
ATOM   822  N  N   . THR A 1 101 ? 0.354   -45.373 21.521  1    86.01  ? 97  THR A N   1 
ATOM   823  C  CA  . THR A 1 101 ? -0.018  -46.626 20.837  1    82.84  ? 97  THR A CA  1 
ATOM   824  C  C   . THR A 1 101 ? -0.936  -46.231 19.702  1    74.31  ? 97  THR A C   1 
ATOM   825  O  O   . THR A 1 101 ? -1.377  -47.123 18.951  1    66.59  ? 97  THR A O   1 
ATOM   826  C  CB  . THR A 1 101 ? -0.677  -47.561 21.846  1    81.89  ? 97  THR A CB  1 
ATOM   827  O  OG1 . THR A 1 101 ? -1.095  -48.7   21.102  1    86.93  ? 97  THR A OG1 1 
ATOM   828  C  CG2 . THR A 1 101 ? -1.867  -46.915 22.533  1    82.26  ? 97  THR A CG2 1 
ATOM   829  N  N   . GLY A 1 102 ? -1.24   -44.94  19.59   1    55.5   ? 98  GLY A N   1 
ATOM   830  C  CA  . GLY A 1 102 ? -2.044  -44.413 18.5    1    43.5   ? 98  GLY A CA  1 
ATOM   831  C  C   . GLY A 1 102 ? -3.401  -43.859 18.935  1    44.71  ? 98  GLY A C   1 
ATOM   832  O  O   . GLY A 1 102 ? -3.795  -43.998 20.106  1    48     ? 98  GLY A O   1 
ATOM   833  N  N   . ILE A 1 103 ? -4.072  -43.178 17.995  1    41.37  ? 99  ILE A N   1 
ATOM   834  C  CA  . ILE A 1 103 ? -5.461  -42.771 18.154  1    39.78  ? 99  ILE A CA  1 
ATOM   835  C  C   . ILE A 1 103 ? -6.35   -43.902 17.636  1    36.05  ? 99  ILE A C   1 
ATOM   836  O  O   . ILE A 1 103 ? -6.15   -44.36  16.516  1    35.64  ? 99  ILE A O   1 
ATOM   837  C  CB  . ILE A 1 103 ? -5.732  -41.468 17.38   1    47.5   ? 99  ILE A CB  1 
ATOM   838  C  CG1 . ILE A 1 103 ? -4.697  -40.397 17.678  1    50.47  ? 99  ILE A CG1 1 
ATOM   839  C  CG2 . ILE A 1 103 ? -7.138  -40.944 17.667  1    49.58  ? 99  ILE A CG2 1 
ATOM   840  C  CD1 . ILE A 1 103 ? -5.119  -39.003 17.236  1    51.67  ? 99  ILE A CD1 1 
ATOM   841  N  N   . PRO A 1 104 ? -7.363  -44.382 18.404  1    32.08  ? 100 PRO A N   1 
ATOM   842  C  CA  . PRO A 1 104 ? -8.239  -45.462 17.924  1    28.71  ? 100 PRO A CA  1 
ATOM   843  C  C   . PRO A 1 104 ? -9.067  -44.994 16.728  1    30.78  ? 100 PRO A C   1 
ATOM   844  O  O   . PRO A 1 104 ? -9.473  -43.83  16.654  1    33.19  ? 100 PRO A O   1 
ATOM   845  C  CB  . PRO A 1 104 ? -9.13   -45.79  19.127  1    30.49  ? 100 PRO A CB  1 
ATOM   846  C  CG  . PRO A 1 104 ? -8.483  -45.1   20.31   1    32.49  ? 100 PRO A CG  1 
ATOM   847  C  CD  . PRO A 1 104 ? -7.729  -43.894 19.745  1    28.76  ? 100 PRO A CD  1 
ATOM   848  N  N   . LEU A 1 105 ? -9.334  -45.909 15.796  1    32.37  ? 101 LEU A N   1 
ATOM   849  C  CA  . LEU A 1 105 ? -9.906  -45.552 14.499  1    32.73  ? 101 LEU A CA  1 
ATOM   850  C  C   . LEU A 1 105 ? -11.266 -44.876 14.684  1    36.02  ? 101 LEU A C   1 
ATOM   851  O  O   . LEU A 1 105 ? -11.518 -43.86  14.05   1    41.42  ? 101 LEU A O   1 
ATOM   852  C  CB  . LEU A 1 105 ? -10     -46.831 13.669  1    32.25  ? 101 LEU A CB  1 
ATOM   853  C  CG  . LEU A 1 105 ? -10.633 -46.763 12.278  1    33.38  ? 101 LEU A CG  1 
ATOM   854  C  CD1 . LEU A 1 105 ? -9.783  -45.854 11.414  1    32.83  ? 101 LEU A CD1 1 
ATOM   855  C  CD2 . LEU A 1 105 ? -10.862 -48.124 11.62   1    32.86  ? 101 LEU A CD2 1 
ATOM   856  N  N   . PRO A 1 106 ? -12.163 -45.364 15.575  1    35.64  ? 102 PRO A N   1 
ATOM   857  C  CA  . PRO A 1 106 ? -13.411 -44.659 15.864  1    33.44  ? 102 PRO A CA  1 
ATOM   858  C  C   . PRO A 1 106 ? -13.193 -43.19  16.185  1    37.4   ? 102 PRO A C   1 
ATOM   859  O  O   . PRO A 1 106 ? -14.019 -42.36  15.791  1    46.24  ? 102 PRO A O   1 
ATOM   860  C  CB  . PRO A 1 106 ? -14.002 -45.375 17.078  1    30.97  ? 102 PRO A CB  1 
ATOM   861  C  CG  . PRO A 1 106 ? -13.412 -46.773 16.984  1    33.69  ? 102 PRO A CG  1 
ATOM   862  C  CD  . PRO A 1 106 ? -12.046 -46.632 16.328  1    34.43  ? 102 PRO A CD  1 
ATOM   863  N  N   . LEU A 1 107 ? -12.111 -42.876 16.918  1    29.38  ? 103 LEU A N   1 
ATOM   864  C  CA  . LEU A 1 107 ? -11.893 -41.513 17.352  1    26.99  ? 103 LEU A CA  1 
ATOM   865  C  C   . LEU A 1 107 ? -11.36  -40.65  16.208  1    28.08  ? 103 LEU A C   1 
ATOM   866  O  O   . LEU A 1 107 ? -11.687 -39.465 16.134  1    25     ? 103 LEU A O   1 
ATOM   867  C  CB  . LEU A 1 107 ? -10.968 -41.504 18.556  1    29.02  ? 103 LEU A CB  1 
ATOM   868  C  CG  . LEU A 1 107 ? -10.917 -40.195 19.356  1    32.21  ? 103 LEU A CG  1 
ATOM   869  C  CD1 . LEU A 1 107 ? -12.331 -39.714 19.742  1    30.78  ? 103 LEU A CD1 1 
ATOM   870  C  CD2 . LEU A 1 107 ? -10.099 -40.45  20.634  1    29.98  ? 103 LEU A CD2 1 
ATOM   871  N  N   . ILE A 1 108 ? -10.544 -41.237 15.317  1    28.32  ? 104 ILE A N   1 
ATOM   872  C  CA  . ILE A 1 108 ? -10.063 -40.533 14.129  1    31.21  ? 104 ILE A CA  1 
ATOM   873  C  C   . ILE A 1 108 ? -11.277 -40.19  13.263  1    32.16  ? 104 ILE A C   1 
ATOM   874  O  O   . ILE A 1 108 ? -11.43  -39.082 12.728  1    30.76  ? 104 ILE A O   1 
ATOM   875  C  CB  . ILE A 1 108 ? -9.037  -41.394 13.355  1    33.37  ? 104 ILE A CB  1 
ATOM   876  C  CG1 . ILE A 1 108 ? -7.769  -41.655 14.177  1    32.23  ? 104 ILE A CG1 1 
ATOM   877  C  CG2 . ILE A 1 108 ? -8.681  -40.777 12      1    33.76  ? 104 ILE A CG2 1 
ATOM   878  C  CD1 . ILE A 1 108 ? -6.808  -42.636 13.521  1    26.9   ? 104 ILE A CD1 1 
ATOM   879  N  N   . LYS A 1 109 ? -12.144 -41.188 13.147  1    28.13  ? 105 LYS A N   1 
ATOM   880  C  CA  . LYS A 1 109 ? -13.273 -41.14  12.242  1    31.02  ? 105 LYS A CA  1 
ATOM   881  C  C   . LYS A 1 109 ? -14.286 -40.086 12.703  1    30.57  ? 105 LYS A C   1 
ATOM   882  O  O   . LYS A 1 109 ? -14.748 -39.274 11.901  1    27.81  ? 105 LYS A O   1 
ATOM   883  C  CB  . LYS A 1 109 ? -13.792 -42.578 12.189  1    29.16  ? 105 LYS A CB  1 
ATOM   884  C  CG  . LYS A 1 109 ? -14.586 -42.913 10.971  1    34.12  ? 105 LYS A CG  1 
ATOM   885  C  CD  . LYS A 1 109 ? -15.021 -44.377 10.989  1    35.11  ? 105 LYS A CD  1 
ATOM   886  C  CE  . LYS A 1 109 ? -13.904 -45.294 10.74   1    29.79  ? 105 LYS A CE  1 
ATOM   887  N  NZ  . LYS A 1 109 ? -14.4   -46.55  10.188  1    32.34  ? 105 LYS A NZ  1 
ATOM   888  N  N   . SER A 1 110 ? -14.611 -40.107 14      1    31.78  ? 106 SER A N   1 
ATOM   889  C  CA  . SER A 1 110 ? -15.404 -39.088 14.683  1    30.44  ? 106 SER A CA  1 
ATOM   890  C  C   . SER A 1 110 ? -14.812 -37.684 14.531  1    28.67  ? 106 SER A C   1 
ATOM   891  O  O   . SER A 1 110 ? -15.555 -36.727 14.273  1    27.78  ? 106 SER A O   1 
ATOM   892  C  CB  . SER A 1 110 ? -15.586 -39.427 16.133  1    29.19  ? 106 SER A CB  1 
ATOM   893  O  OG  . SER A 1 110 ? -16.103 -38.303 16.824  1    35.8   ? 106 SER A OG  1 
ATOM   894  N  N   . TYR A 1 111 ? -13.487 -37.562 14.682  1    28.07  ? 107 TYR A N   1 
ATOM   895  C  CA  . TYR A 1 111 ? -12.88  -36.237 14.681  1    33.56  ? 107 TYR A CA  1 
ATOM   896  C  C   . TYR A 1 111 ? -12.908 -35.655 13.265  1    37     ? 107 TYR A C   1 
ATOM   897  O  O   . TYR A 1 111 ? -13.199 -34.459 13.087  1    35.96  ? 107 TYR A O   1 
ATOM   898  C  CB  . TYR A 1 111 ? -11.455 -36.207 15.24   1    29.01  ? 107 TYR A CB  1 
ATOM   899  C  CG  . TYR A 1 111 ? -11.283 -36.146 16.751  1    33.26  ? 107 TYR A CG  1 
ATOM   900  C  CD1 . TYR A 1 111 ? -12.362 -35.901 17.618  1    29.91  ? 107 TYR A CD1 1 
ATOM   901  C  CD2 . TYR A 1 111 ? -10.02  -36.366 17.319  1    30.34  ? 107 TYR A CD2 1 
ATOM   902  C  CE1 . TYR A 1 111 ? -12.176 -35.869 18.996  1    26.4   ? 107 TYR A CE1 1 
ATOM   903  C  CE2 . TYR A 1 111 ? -9.83   -36.309 18.693  1    29.2   ? 107 TYR A CE2 1 
ATOM   904  C  CZ  . TYR A 1 111 ? -10.908 -36.06  19.527  1    26.57  ? 107 TYR A CZ  1 
ATOM   905  O  OH  . TYR A 1 111 ? -10.701 -36.009 20.865  1    27.45  ? 107 TYR A OH  1 
ATOM   906  N  N   . LEU A 1 112 ? -12.576 -36.493 12.269  1    33.41  ? 108 LEU A N   1 
ATOM   907  C  CA  . LEU A 1 112 ? -12.522 -36.018 10.892  1    35.58  ? 108 LEU A CA  1 
ATOM   908  C  C   . LEU A 1 112 ? -13.942 -35.616 10.432  1    39.44  ? 108 LEU A C   1 
ATOM   909  O  O   . LEU A 1 112 ? -14.169 -34.556 9.812   1    35.62  ? 108 LEU A O   1 
ATOM   910  C  CB  . LEU A 1 112 ? -11.869 -37.074 10      1    25.68  ? 108 LEU A CB  1 
ATOM   911  C  CG  . LEU A 1 112 ? -11.792 -36.665 8.532   1    28.29  ? 108 LEU A CG  1 
ATOM   912  C  CD1 . LEU A 1 112 ? -10.963 -35.363 8.408   1    28.25  ? 108 LEU A CD1 1 
ATOM   913  C  CD2 . LEU A 1 112 ? -11.273 -37.777 7.629   1    25.33  ? 108 LEU A CD2 1 
ATOM   914  N  N   . PHE A 1 113 ? -14.917 -36.466 10.794  1    34.32  ? 109 PHE A N   1 
ATOM   915  C  CA  . PHE A 1 113 ? -16.315 -36.158 10.544  1    35.52  ? 109 PHE A CA  1 
ATOM   916  C  C   . PHE A 1 113 ? -16.719 -34.791 11.105  1    34.47  ? 109 PHE A C   1 
ATOM   917  O  O   . PHE A 1 113 ? -17.385 -34.012 10.423  1    36.47  ? 109 PHE A O   1 
ATOM   918  C  CB  . PHE A 1 113 ? -17.197 -37.221 11.173  1    35.6   ? 109 PHE A CB  1 
ATOM   919  C  CG  . PHE A 1 113 ? -18.588 -37.211 10.561  1    35.58  ? 109 PHE A CG  1 
ATOM   920  C  CD1 . PHE A 1 113 ? -18.759 -37.481 9.211   1    29.98  ? 109 PHE A CD1 1 
ATOM   921  C  CD2 . PHE A 1 113 ? -19.701 -36.941 11.343  1    32.09  ? 109 PHE A CD2 1 
ATOM   922  C  CE1 . PHE A 1 113 ? -20.015 -37.498 8.666   1    28.49  ? 109 PHE A CE1 1 
ATOM   923  C  CE2 . PHE A 1 113 ? -20.958 -36.985 10.793  1    30.71  ? 109 PHE A CE2 1 
ATOM   924  C  CZ  . PHE A 1 113 ? -21.108 -37.274 9.465   1    30.06  ? 109 PHE A CZ  1 
ATOM   925  N  N   . GLN A 1 114 ? -16.319 -34.485 12.348  1    33.31  ? 110 GLN A N   1 
ATOM   926  C  CA  . GLN A 1 114 ? -16.701 -33.231 12.977  1    27.81  ? 110 GLN A CA  1 
ATOM   927  C  C   . GLN A 1 114 ? -15.965 -32.074 12.315  1    31.66  ? 110 GLN A C   1 
ATOM   928  O  O   . GLN A 1 114 ? -16.581 -31.029 12.088  1    31.5   ? 110 GLN A O   1 
ATOM   929  C  CB  . GLN A 1 114 ? -16.397 -33.272 14.463  1    26.46  ? 110 GLN A CB  1 
ATOM   930  C  CG  . GLN A 1 114 ? -17.366 -34.107 15.257  1    27.18  ? 110 GLN A CG  1 
ATOM   931  C  CD  . GLN A 1 114 ? -16.915 -34.206 16.693  1    33.64  ? 110 GLN A CD  1 
ATOM   932  O  OE1 . GLN A 1 114 ? -16.941 -33.206 17.427  1    30.29  ? 110 GLN A OE1 1 
ATOM   933  N  NE2 . GLN A 1 114 ? -16.494 -35.406 17.103  1    29.23  ? 110 GLN A NE2 1 
ATOM   934  N  N   . LEU A 1 115 ? -14.669 -32.262 12.001  1    27.16  ? 111 LEU A N   1 
ATOM   935  C  CA  . LEU A 1 115 ? -13.923 -31.214 11.312  1    31.19  ? 111 LEU A CA  1 
ATOM   936  C  C   . LEU A 1 115 ? -14.595 -30.836 9.985   1    31.83  ? 111 LEU A C   1 
ATOM   937  O  O   . LEU A 1 115 ? -14.743 -29.67  9.653   1    34.08  ? 111 LEU A O   1 
ATOM   938  C  CB  . LEU A 1 115 ? -12.49  -31.68  11.078  1    33.74  ? 111 LEU A CB  1 
ATOM   939  C  CG  . LEU A 1 115 ? -11.626 -31.799 12.337  1    33.06  ? 111 LEU A CG  1 
ATOM   940  C  CD1 . LEU A 1 115 ? -10.293 -32.452 12.01   1    29.03  ? 111 LEU A CD1 1 
ATOM   941  C  CD2 . LEU A 1 115 ? -11.413 -30.436 12.962  1    29.73  ? 111 LEU A CD2 1 
ATOM   942  N  N   . LEU A 1 116 ? -15.006 -31.829 9.208   1    30.47  ? 112 LEU A N   1 
ATOM   943  C  CA  . LEU A 1 116 ? -15.679 -31.58  7.939   1    30.36  ? 112 LEU A CA  1 
ATOM   944  C  C   . LEU A 1 116 ? -16.994 -30.831 8.132   1    29.29  ? 112 LEU A C   1 
ATOM   945  O  O   . LEU A 1 116 ? -17.353 -30.019 7.275   1    32.57  ? 112 LEU A O   1 
ATOM   946  C  CB  . LEU A 1 116 ? -15.915 -32.902 7.203   1    28.27  ? 112 LEU A CB  1 
ATOM   947  C  CG  . LEU A 1 116 ? -14.645 -33.537 6.652   1    28.04  ? 112 LEU A CG  1 
ATOM   948  C  CD1 . LEU A 1 116 ? -14.794 -34.99  6.386   1    26.9   ? 112 LEU A CD1 1 
ATOM   949  C  CD2 . LEU A 1 116 ? -14.166 -32.751 5.46    1    30.96  ? 112 LEU A CD2 1 
ATOM   950  N  N   . GLN A 1 117 ? -17.726 -31.142 9.211   1    26.82  ? 113 GLN A N   1 
ATOM   951  C  CA  . GLN A 1 117 ? -18.966 -30.428 9.469   1    28.07  ? 113 GLN A CA  1 
ATOM   952  C  C   . GLN A 1 117 ? -18.655 -28.948 9.688   1    32.6   ? 113 GLN A C   1 
ATOM   953  O  O   . GLN A 1 117 ? -19.336 -28.085 9.139   1    35.17  ? 113 GLN A O   1 
ATOM   954  C  CB  . GLN A 1 117 ? -19.711 -30.987 10.67   1    26.85  ? 113 GLN A CB  1 
ATOM   955  C  CG  . GLN A 1 117 ? -20.318 -32.369 10.464  1    27.06  ? 113 GLN A CG  1 
ATOM   956  C  CD  . GLN A 1 117 ? -21.059 -32.787 11.72   1    32.03  ? 113 GLN A CD  1 
ATOM   957  O  OE1 . GLN A 1 117 ? -22.016 -32.134 12.175  1    33.67  ? 113 GLN A OE1 1 
ATOM   958  N  NE2 . GLN A 1 117 ? -20.613 -33.885 12.309  1    30.38  ? 113 GLN A NE2 1 
ATOM   959  N  N   . GLY A 1 118 ? -17.591 -28.657 10.456  1    29.86  ? 114 GLY A N   1 
ATOM   960  C  CA  . GLY A 1 118 ? -17.303 -27.293 10.86   1    25.74  ? 114 GLY A CA  1 
ATOM   961  C  C   . GLY A 1 118 ? -16.864 -26.476 9.662   1    27.56  ? 114 GLY A C   1 
ATOM   962  O  O   . GLY A 1 118 ? -17.225 -25.298 9.498   1    27.38  ? 114 GLY A O   1 
ATOM   963  N  N   . LEU A 1 119 ? -16.064 -27.135 8.824   1    30.11  ? 115 LEU A N   1 
ATOM   964  C  CA  . LEU A 1 119 ? -15.498 -26.478 7.658   1    32.91  ? 115 LEU A CA  1 
ATOM   965  C  C   . LEU A 1 119 ? -16.588 -26.243 6.604   1    37.24  ? 115 LEU A C   1 
ATOM   966  O  O   . LEU A 1 119 ? -16.595 -25.202 5.933   1    36.1   ? 115 LEU A O   1 
ATOM   967  C  CB  . LEU A 1 119 ? -14.375 -27.361 7.119   1    31.6   ? 115 LEU A CB  1 
ATOM   968  C  CG  . LEU A 1 119 ? -13.607 -26.757 5.948   1    31.92  ? 115 LEU A CG  1 
ATOM   969  C  CD1 . LEU A 1 119 ? -12.948 -25.434 6.365   1    32.41  ? 115 LEU A CD1 1 
ATOM   970  C  CD2 . LEU A 1 119 ? -12.576 -27.761 5.441   1    31.45  ? 115 LEU A CD2 1 
ATOM   971  N  N   . ALA A 1 120 ? -17.509 -27.217 6.463   1    30.94  ? 116 ALA A N   1 
ATOM   972  C  CA  . ALA A 1 120 ? -18.604 -27.037 5.525   1    30.85  ? 116 ALA A CA  1 
ATOM   973  C  C   . ALA A 1 120 ? -19.408 -25.812 5.945   1    28.89  ? 116 ALA A C   1 
ATOM   974  O  O   . ALA A 1 120 ? -19.85  -25.029 5.109   1    27.98  ? 116 ALA A O   1 
ATOM   975  C  CB  . ALA A 1 120 ? -19.481 -28.278 5.459   1    28.26  ? 116 ALA A CB  1 
ATOM   976  N  N   . PHE A 1 121 ? -19.588 -25.659 7.26    1    27.57  ? 117 PHE A N   1 
ATOM   977  C  CA  . PHE A 1 121 ? -20.336 -24.537 7.788   1    28.01  ? 117 PHE A CA  1 
ATOM   978  C  C   . PHE A 1 121 ? -19.578 -23.248 7.499   1    31.1   ? 117 PHE A C   1 
ATOM   979  O  O   . PHE A 1 121 ? -20.212 -22.256 7.123   1    34.98  ? 117 PHE A O   1 
ATOM   980  C  CB  . PHE A 1 121 ? -20.642 -24.683 9.275   1    26.28  ? 117 PHE A CB  1 
ATOM   981  C  CG  . PHE A 1 121 ? -21.531 -23.583 9.823   1    29.99  ? 117 PHE A CG  1 
ATOM   982  C  CD1 . PHE A 1 121 ? -20.975 -22.377 10.271  1    27.5   ? 117 PHE A CD1 1 
ATOM   983  C  CD2 . PHE A 1 121 ? -22.926 -23.749 9.89    1    25.89  ? 117 PHE A CD2 1 
ATOM   984  C  CE1 . PHE A 1 121 ? -21.796 -21.353 10.76   1    28.61  ? 117 PHE A CE1 1 
ATOM   985  C  CE2 . PHE A 1 121 ? -23.738 -22.731 10.413  1    24.41  ? 117 PHE A CE2 1 
ATOM   986  C  CZ  . PHE A 1 121 ? -23.179 -21.536 10.862  1    25     ? 117 PHE A CZ  1 
ATOM   987  N  N   . CYS A 1 122 ? -18.234 -23.288 7.619   1    30.84  ? 118 CYS A N   1 
ATOM   988  C  CA  . CYS A 1 122 ? -17.443 -22.13  7.217   1    32.92  ? 118 CYS A CA  1 
ATOM   989  C  C   . CYS A 1 122 ? -17.68  -21.777 5.746   1    34.09  ? 118 CYS A C   1 
ATOM   990  O  O   . CYS A 1 122 ? -18.012 -20.633 5.411   1    32.63  ? 118 CYS A O   1 
ATOM   991  C  CB  . CYS A 1 122 ? -15.961 -22.363 7.426   1    34.37  ? 118 CYS A CB  1 
ATOM   992  S  SG  . CYS A 1 122 ? -15.506 -22.365 9.174   1    35.23  ? 118 CYS A SG  1 
ATOM   993  N  N   . HIS A 1 123 ? -17.5   -22.772 4.871   1    30.69  ? 119 HIS A N   1 
ATOM   994  C  CA  . HIS A 1 123 ? -17.539 -22.528 3.444   1    29.51  ? 119 HIS A CA  1 
ATOM   995  C  C   . HIS A 1 123 ? -18.936 -22.062 3.01    1    32.97  ? 119 HIS A C   1 
ATOM   996  O  O   . HIS A 1 123 ? -19.041 -21.262 2.07    1    32.7   ? 119 HIS A O   1 
ATOM   997  C  CB  . HIS A 1 123 ? -17.049 -23.777 2.716   1    27.41  ? 119 HIS A CB  1 
ATOM   998  C  CG  . HIS A 1 123 ? -15.598 -24.043 2.922   1    33.4   ? 119 HIS A CG  1 
ATOM   999  N  ND1 . HIS A 1 123 ? -14.968 -25.206 2.509   1    30.91  ? 119 HIS A ND1 1 
ATOM   1000 C  CD2 . HIS A 1 123 ? -14.639 -23.249 3.472   1    31.29  ? 119 HIS A CD2 1 
ATOM   1001 C  CE1 . HIS A 1 123 ? -13.677 -25.105 2.819   1    36.02  ? 119 HIS A CE1 1 
ATOM   1002 N  NE2 . HIS A 1 123 ? -13.456 -23.924 3.41    1    33.01  ? 119 HIS A NE2 1 
ATOM   1003 N  N   . SER A 1 124 ? -19.968 -22.53  3.704   1    26.66  ? 120 SER A N   1 
ATOM   1004 C  CA  . SER A 1 124 ? -21.364 -22.139 3.395   1    30.77  ? 120 SER A CA  1 
ATOM   1005 C  C   . SER A 1 124 ? -21.627 -20.713 3.894   1    27.7   ? 120 SER A C   1 
ATOM   1006 O  O   . SER A 1 124 ? -22.666 -20.149 3.533   1    27.69  ? 120 SER A O   1 
ATOM   1007 C  CB  . SER A 1 124 ? -22.323 -23.116 4.001   1    31.5   ? 120 SER A CB  1 
ATOM   1008 O  OG  . SER A 1 124 ? -22.202 -24.403 3.416   1    33.42  ? 120 SER A OG  1 
ATOM   1009 N  N   . HIS A 1 125 ? -20.7   -20.161 4.671   1    27.08  ? 121 HIS A N   1 
ATOM   1010 C  CA  . HIS A 1 125 ? -20.843 -18.785 5.208   1    29.14  ? 121 HIS A CA  1 
ATOM   1011 C  C   . HIS A 1 125 ? -19.718 -17.913 4.647   1    29.79  ? 121 HIS A C   1 
ATOM   1012 O  O   . HIS A 1 125 ? -19.262 -17.024 5.371   1    28.18  ? 121 HIS A O   1 
ATOM   1013 C  CB  . HIS A 1 125 ? -20.941 -18.845 6.733   1    28.39  ? 121 HIS A CB  1 
ATOM   1014 C  CG  . HIS A 1 125 ? -22.217 -19.456 7.188   1    34.11  ? 121 HIS A CG  1 
ATOM   1015 N  ND1 . HIS A 1 125 ? -22.457 -20.809 7.121   1    31.96  ? 121 HIS A ND1 1 
ATOM   1016 C  CD2 . HIS A 1 125 ? -23.322 -18.907 7.684   1    34.18  ? 121 HIS A CD2 1 
ATOM   1017 C  CE1 . HIS A 1 125 ? -23.675 -21.053 7.563   1    36.62  ? 121 HIS A CE1 1 
ATOM   1018 N  NE2 . HIS A 1 125 ? -24.215 -19.913 7.921   1    34.13  ? 121 HIS A NE2 1 
ATOM   1019 N  N   . ARG A 1 126 ? -19.329 -18.15  3.387   1    27.59  ? 122 ARG A N   1 
ATOM   1020 C  CA  . ARG A 1 126 ? -18.27  -17.352 2.707   1    26.35  ? 122 ARG A CA  1 
ATOM   1021 C  C   . ARG A 1 126 ? -17.082 -17.091 3.65    1    26.64  ? 122 ARG A C   1 
ATOM   1022 O  O   . ARG A 1 126 ? -16.718 -15.908 3.806   1    27.62  ? 122 ARG A O   1 
ATOM   1023 C  CB  . ARG A 1 126 ? -18.794 -16.022 2.146   1    22.8   ? 122 ARG A CB  1 
ATOM   1024 C  CG  . ARG A 1 126 ? -20.272 -15.702 2.31    1    22.91  ? 122 ARG A CG  1 
ATOM   1025 C  CD  . ARG A 1 126 ? -20.487 -14.549 3.273   1    23.8   ? 122 ARG A CD  1 
ATOM   1026 N  NE  . ARG A 1 126 ? -19.285 -14.271 4.066   1    37.39  ? 122 ARG A NE  1 
ATOM   1027 C  CZ  . ARG A 1 126 ? -19.263 -13.498 5.141   1    35.62  ? 122 ARG A CZ  1 
ATOM   1028 N  NH1 . ARG A 1 126 ? -18.434 -13.77  6.132   1    30.46  ? 122 ARG A NH1 1 
ATOM   1029 N  NH2 . ARG A 1 126 ? -20.073 -12.458 5.22    1    28.48  ? 122 ARG A NH2 1 
ATOM   1030 N  N   . VAL A 1 127 ? -16.491 -18.144 4.224   1    26.94  ? 123 VAL A N   1 
ATOM   1031 C  CA  . VAL A 1 127 ? -15.279 -17.989 5.084   1    28.12  ? 123 VAL A CA  1 
ATOM   1032 C  C   . VAL A 1 127 ? -14.227 -19.082 4.826   1    32.54  ? 123 VAL A C   1 
ATOM   1033 O  O   . VAL A 1 127 ? -14.567 -20.261 4.957   1    32.16  ? 123 VAL A O   1 
ATOM   1034 C  CB  . VAL A 1 127 ? -15.635 -17.931 6.582   1    29.97  ? 123 VAL A CB  1 
ATOM   1035 C  CG1 . VAL A 1 127 ? -14.408 -18.094 7.471   1    21.03  ? 123 VAL A CG1 1 
ATOM   1036 C  CG2 . VAL A 1 127 ? -16.377 -16.654 6.947   1    23.92  ? 123 VAL A CG2 1 
ATOM   1037 N  N   . LEU A 1 128 ? -13.006 -18.692 4.45    1    28.36  ? 124 LEU A N   1 
ATOM   1038 C  CA  . LEU A 1 128 ? -11.894 -19.629 4.355   1    26.68  ? 124 LEU A CA  1 
ATOM   1039 C  C   . LEU A 1 128 ? -11.158 -19.572 5.686   1    29.46  ? 124 LEU A C   1 
ATOM   1040 O  O   . LEU A 1 128 ? -10.976 -18.473 6.224   1    31.29  ? 124 LEU A O   1 
ATOM   1041 C  CB  . LEU A 1 128 ? -10.933 -19.255 3.221   1    27.22  ? 124 LEU A CB  1 
ATOM   1042 C  CG  . LEU A 1 128 ? -11.467 -19.226 1.786   1    27.12  ? 124 LEU A CG  1 
ATOM   1043 C  CD1 . LEU A 1 128 ? -10.385 -18.85  0.817   1    27.46  ? 124 LEU A CD1 1 
ATOM   1044 C  CD2 . LEU A 1 128 ? -11.995 -20.569 1.396   1    26.34  ? 124 LEU A CD2 1 
ATOM   1045 N  N   . HIS A 1 129 ? -10.688 -20.725 6.171   1    26.85  ? 125 HIS A N   1 
ATOM   1046 C  CA  . HIS A 1 129 ? -9.959  -20.758 7.424   1    28.26  ? 125 HIS A CA  1 
ATOM   1047 C  C   . HIS A 1 129 ? -8.497  -20.358 7.228   1    31.02  ? 125 HIS A C   1 
ATOM   1048 O  O   . HIS A 1 129 ? -8.029  -19.445 7.91    1    28.79  ? 125 HIS A O   1 
ATOM   1049 C  CB  . HIS A 1 129 ? -10.098 -22.104 8.132   1    28.33  ? 125 HIS A CB  1 
ATOM   1050 C  CG  . HIS A 1 129 ? -9.521  -22.04  9.506   1    32.74  ? 125 HIS A CG  1 
ATOM   1051 N  ND1 . HIS A 1 129 ? -8.164  -22.02  9.694   1    32.9   ? 125 HIS A ND1 1 
ATOM   1052 C  CD2 . HIS A 1 129 ? -10.049 -21.936 10.728  1    36.14  ? 125 HIS A CD2 1 
ATOM   1053 C  CE1 . HIS A 1 129 ? -7.886  -21.921 10.99   1    37.36  ? 125 HIS A CE1 1 
ATOM   1054 N  NE2 . HIS A 1 129 ? -9.015  -21.875 11.644  1    35.71  ? 125 HIS A NE2 1 
ATOM   1055 N  N   . ARG A 1 130 ? -7.771  -21.101 6.367   1    32.18  ? 126 ARG A N   1 
ATOM   1056 C  CA  . ARG A 1 130 ? -6.456  -20.721 5.846   1    35.06  ? 126 ARG A CA  1 
ATOM   1057 C  C   . ARG A 1 130 ? -5.332  -20.951 6.864   1    37.04  ? 126 ARG A C   1 
ATOM   1058 O  O   . ARG A 1 130 ? -4.235  -20.421 6.674   1    41.87  ? 126 ARG A O   1 
ATOM   1059 C  CB  . ARG A 1 130 ? -6.466  -19.285 5.292   1    31.89  ? 126 ARG A CB  1 
ATOM   1060 C  CG  . ARG A 1 130 ? -7.393  -19.049 4.105   1    29.26  ? 126 ARG A CG  1 
ATOM   1061 C  CD  . ARG A 1 130 ? -7.064  -17.803 3.314   1    25.46  ? 126 ARG A CD  1 
ATOM   1062 N  NE  . ARG A 1 130 ? -7.035  -16.693 4.266   1    26.2   ? 126 ARG A NE  1 
ATOM   1063 C  CZ  . ARG A 1 130 ? -6.681  -15.434 3.968   1    28.75  ? 126 ARG A CZ  1 
ATOM   1064 N  NH1 . ARG A 1 130 ? -6.314  -15.104 2.737   1    25.93  ? 126 ARG A NH1 1 
ATOM   1065 N  NH2 . ARG A 1 130 ? -6.714  -14.497 4.907   1    24.3   ? 126 ARG A NH2 1 
ATOM   1066 N  N   . ASP A 1 131 ? -5.592  -21.75  7.926   1    34.2   ? 127 ASP A N   1 
ATOM   1067 C  CA  . ASP A 1 131 ? -4.568  -22.169 8.87    1    33.81  ? 127 ASP A CA  1 
ATOM   1068 C  C   . ASP A 1 131 ? -5.046  -23.402 9.628   1    38.3   ? 127 ASP A C   1 
ATOM   1069 O  O   . ASP A 1 131 ? -4.845  -23.512 10.85   1    39.85  ? 127 ASP A O   1 
ATOM   1070 C  CB  . ASP A 1 131 ? -4.089  -21.067 9.809   1    34.64  ? 127 ASP A CB  1 
ATOM   1071 C  CG  . ASP A 1 131 ? -2.657  -21.301 10.25   1    34.23  ? 127 ASP A CG  1 
ATOM   1072 O  OD1 . ASP A 1 131 ? -1.981  -22.145 9.59    1    39.54  ? 127 ASP A OD1 1 
ATOM   1073 O  OD2 . ASP A 1 131 ? -2.258  -20.696 11.253  1    34.95  ? 127 ASP A OD2 1 
ATOM   1074 N  N   . LEU A 1 132 ? -5.645  -24.361 8.892   1    32.67  ? 128 LEU A N   1 
ATOM   1075 C  CA  . LEU A 1 132 ? -6.043  -25.591 9.567   1    34.82  ? 128 LEU A CA  1 
ATOM   1076 C  C   . LEU A 1 132 ? -4.807  -26.478 9.773   1    37.06  ? 128 LEU A C   1 
ATOM   1077 O  O   . LEU A 1 132 ? -4.071  -26.797 8.844   1    42.28  ? 128 LEU A O   1 
ATOM   1078 C  CB  . LEU A 1 132 ? -7.177  -26.27  8.806   1    38.73  ? 128 LEU A CB  1 
ATOM   1079 C  CG  . LEU A 1 132 ? -8.499  -25.493 8.768   1    37.53  ? 128 LEU A CG  1 
ATOM   1080 C  CD1 . LEU A 1 132 ? -9.378  -26.059 7.643   1    28.08  ? 128 LEU A CD1 1 
ATOM   1081 C  CD2 . LEU A 1 132 ? -9.188  -25.523 10.151  1    39.59  ? 128 LEU A CD2 1 
ATOM   1082 N  N   . LYS A 1 133 ? -4.524  -26.78  11.03   1    30.23  ? 129 LYS A N   1 
ATOM   1083 C  CA  . LYS A 1 133 ? -3.394  -27.573 11.474  1    31.25  ? 129 LYS A CA  1 
ATOM   1084 C  C   . LYS A 1 133 ? -3.796  -28.065 12.859  1    34.27  ? 129 LYS A C   1 
ATOM   1085 O  O   . LYS A 1 133 ? -4.758  -27.546 13.418  1    36.61  ? 129 LYS A O   1 
ATOM   1086 C  CB  . LYS A 1 133 ? -2.115  -26.732 11.496  1    26.95  ? 129 LYS A CB  1 
ATOM   1087 C  CG  . LYS A 1 133 ? -2.181  -25.493 12.381  1    30.19  ? 129 LYS A CG  1 
ATOM   1088 C  CD  . LYS A 1 133 ? -0.809  -24.854 12.493  1    32.07  ? 129 LYS A CD  1 
ATOM   1089 C  CE  . LYS A 1 133 ? -0.798  -23.605 13.301  1    35.1   ? 129 LYS A CE  1 
ATOM   1090 N  NZ  . LYS A 1 133 ? 0.445   -22.865 13.063  1    35.67  ? 129 LYS A NZ  1 
ATOM   1091 N  N   . PRO A 1 134 ? -3.169  -29.117 13.43   1    36.32  ? 130 PRO A N   1 
ATOM   1092 C  CA  . PRO A 1 134 ? -3.671  -29.715 14.685  1    34.41  ? 130 PRO A CA  1 
ATOM   1093 C  C   . PRO A 1 134 ? -3.624  -28.797 15.901  1    38.67  ? 130 PRO A C   1 
ATOM   1094 O  O   . PRO A 1 134 ? -4.426  -28.936 16.824  1    42.39  ? 130 PRO A O   1 
ATOM   1095 C  CB  . PRO A 1 134 ? -2.772  -30.925 14.88   1    29.65  ? 130 PRO A CB  1 
ATOM   1096 C  CG  . PRO A 1 134 ? -2.218  -31.184 13.495  1    29.94  ? 130 PRO A CG  1 
ATOM   1097 C  CD  . PRO A 1 134 ? -2.006  -29.815 12.87   1    31.52  ? 130 PRO A CD  1 
ATOM   1098 N  N   . GLN A 1 135 ? -2.644  -27.886 15.901  1    35.78  ? 131 GLN A N   1 
ATOM   1099 C  CA  . GLN A 1 135 ? -2.511  -26.842 16.902  1    29.93  ? 131 GLN A CA  1 
ATOM   1100 C  C   . GLN A 1 135 ? -3.774  -25.974 16.955  1    30.56  ? 131 GLN A C   1 
ATOM   1101 O  O   . GLN A 1 135 ? -4.055  -25.357 17.974  1    30.18  ? 131 GLN A O   1 
ATOM   1102 C  CB  . GLN A 1 135 ? -1.3    -25.98  16.554  1    30.23  ? 131 GLN A CB  1 
ATOM   1103 C  CG  . GLN A 1 135 ? 0.062   -26.665 16.713  1    39.33  ? 131 GLN A CG  1 
ATOM   1104 C  CD  . GLN A 1 135 ? 0.601   -27.449 15.516  1    45.29  ? 131 GLN A CD  1 
ATOM   1105 O  OE1 . GLN A 1 135 ? -0.08   -27.814 14.542  1    40.99  ? 131 GLN A OE1 1 
ATOM   1106 N  NE2 . GLN A 1 135 ? 1.878   -27.776 15.605  1    53.52  ? 131 GLN A NE2 1 
ATOM   1107 N  N   . ASN A 1 136 ? -4.516  -25.869 15.846  1    28.47  ? 132 ASN A N   1 
ATOM   1108 C  CA  . ASN A 1 136 ? -5.606  -24.901 15.767  1    29.81  ? 132 ASN A CA  1 
ATOM   1109 C  C   . ASN A 1 136 ? -6.935  -25.652 15.884  1    31.1   ? 132 ASN A C   1 
ATOM   1110 O  O   . ASN A 1 136 ? -7.98   -25.121 15.538  1    32.2   ? 132 ASN A O   1 
ATOM   1111 C  CB  . ASN A 1 136 ? -5.513  -24.056 14.489  1    26.96  ? 132 ASN A CB  1 
ATOM   1112 C  CG  . ASN A 1 136 ? -4.444  -22.987 14.521  1    29.18  ? 132 ASN A CG  1 
ATOM   1113 O  OD1 . ASN A 1 136 ? -3.98   -22.571 15.586  1    31.76  ? 132 ASN A OD1 1 
ATOM   1114 N  ND2 . ASN A 1 136 ? -4.012  -22.519 13.363  1    28.8   ? 132 ASN A ND2 1 
ATOM   1115 N  N   . LEU A 1 137 ? -6.876  -26.919 16.315  1    29.32  ? 133 LEU A N   1 
ATOM   1116 C  CA  . LEU A 1 137 ? -8.059  -27.739 16.482  1    29.11  ? 133 LEU A CA  1 
ATOM   1117 C  C   . LEU A 1 137 ? -8.165  -28.145 17.96   1    30.23  ? 133 LEU A C   1 
ATOM   1118 O  O   . LEU A 1 137 ? -7.249  -28.774 18.49   1    27.49  ? 133 LEU A O   1 
ATOM   1119 C  CB  . LEU A 1 137 ? -7.937  -28.928 15.542  1    29.47  ? 133 LEU A CB  1 
ATOM   1120 C  CG  . LEU A 1 137 ? -7.707  -28.607 14.062  1    33.24  ? 133 LEU A CG  1 
ATOM   1121 C  CD1 . LEU A 1 137 ? -7.762  -29.882 13.232  1    31.45  ? 133 LEU A CD1 1 
ATOM   1122 C  CD2 . LEU A 1 137 ? -8.769  -27.664 13.562  1    34.36  ? 133 LEU A CD2 1 
ATOM   1123 N  N   . LEU A 1 138 ? -9.262  -27.736 18.619  1    25.15  ? 134 LEU A N   1 
ATOM   1124 C  CA  . LEU A 1 138 ? -9.433  -27.879 20.051  1    27.84  ? 134 LEU A CA  1 
ATOM   1125 C  C   . LEU A 1 138 ? -10.387 -29.026 20.377  1    27.81  ? 134 LEU A C   1 
ATOM   1126 O  O   . LEU A 1 138 ? -11.433 -29.154 19.763  1    36.12  ? 134 LEU A O   1 
ATOM   1127 C  CB  . LEU A 1 138 ? -9.936  -26.541 20.601  1    25.56  ? 134 LEU A CB  1 
ATOM   1128 C  CG  . LEU A 1 138 ? -8.953  -25.371 20.477  1    27.53  ? 134 LEU A CG  1 
ATOM   1129 C  CD1 . LEU A 1 138 ? -9.491  -24.147 21.139  1    24.36  ? 134 LEU A CD1 1 
ATOM   1130 C  CD2 . LEU A 1 138 ? -7.586  -25.651 21.081  1    26.06  ? 134 LEU A CD2 1 
ATOM   1131 N  N   . ILE A 1 139 ? -9.984  -29.844 21.338  1    25.41  ? 135 ILE A N   1 
ATOM   1132 C  CA  . ILE A 1 139 ? -10.801 -31.025 21.716  1    27.94  ? 135 ILE A CA  1 
ATOM   1133 C  C   . ILE A 1 139 ? -11.322 -30.835 23.145  1    26.01  ? 135 ILE A C   1 
ATOM   1134 O  O   . ILE A 1 139 ? -10.651 -30.169 23.94   1    26.79  ? 135 ILE A O   1 
ATOM   1135 C  CB  . ILE A 1 139 ? -9.971  -32.311 21.562  1    29.22  ? 135 ILE A CB  1 
ATOM   1136 C  CG1 . ILE A 1 139 ? -8.655  -32.233 22.317  1    31.15  ? 135 ILE A CG1 1 
ATOM   1137 C  CG2 . ILE A 1 139 ? -9.747  -32.645 20.089  1    23.84  ? 135 ILE A CG2 1 
ATOM   1138 C  CD1 . ILE A 1 139 ? -8.062  -33.59  22.637  1    32.49  ? 135 ILE A CD1 1 
ATOM   1139 N  N   . ASN A 1 140 ? -12.494 -31.387 23.435  1    27.89  ? 136 ASN A N   1 
ATOM   1140 C  CA  . ASN A 1 140 ? -13.059 -31.313 24.806  1    30.77  ? 136 ASN A CA  1 
ATOM   1141 C  C   . ASN A 1 140 ? -12.986 -32.695 25.453  1    30.55  ? 136 ASN A C   1 
ATOM   1142 O  O   . ASN A 1 140 ? -12.384 -33.588 24.854  1    28.07  ? 136 ASN A O   1 
ATOM   1143 C  CB  . ASN A 1 140 ? -14.464 -30.715 24.825  1    27.19  ? 136 ASN A CB  1 
ATOM   1144 C  CG  . ASN A 1 140 ? -15.551 -31.611 24.285  1    31.39  ? 136 ASN A CG  1 
ATOM   1145 O  OD1 . ASN A 1 140 ? -15.288 -32.695 23.757  1    28.94  ? 136 ASN A OD1 1 
ATOM   1146 N  ND2 . ASN A 1 140 ? -16.79  -31.166 24.407  1    33.45  ? 136 ASN A ND2 1 
ATOM   1147 N  N   . THR A 1 141 ? -13.612 -32.849 26.612  1    35.17  ? 137 THR A N   1 
ATOM   1148 C  CA  . THR A 1 141 ? -13.599 -34.121 27.349  1    34.53  ? 137 THR A CA  1 
ATOM   1149 C  C   . THR A 1 141 ? -14.799 -34.938 26.944  1    38.35  ? 137 THR A C   1 
ATOM   1150 O  O   . THR A 1 141 ? -14.903 -36.085 27.396  1    38.99  ? 137 THR A O   1 
ATOM   1151 C  CB  . THR A 1 141 ? -13.619 -33.774 28.835  1    30.45  ? 137 THR A CB  1 
ATOM   1152 O  OG1 . THR A 1 141 ? -14.684 -32.845 29.002  1    33.01  ? 137 THR A OG1 1 
ATOM   1153 C  CG2 . THR A 1 141 ? -12.322 -33.142 29.301  1    30.17  ? 137 THR A CG2 1 
ATOM   1154 N  N   . GLU A 1 142 ? -15.661 -34.385 26.098  1    35.99  ? 138 GLU A N   1 
ATOM   1155 C  CA  . GLU A 1 142 ? -16.916 -35.08  25.731  1    41.2   ? 138 GLU A CA  1 
ATOM   1156 C  C   . GLU A 1 142 ? -16.807 -35.674 24.327  1    40.29  ? 138 GLU A C   1 
ATOM   1157 O  O   . GLU A 1 142 ? -17.773 -36.317 23.893  1    46.61  ? 138 GLU A O   1 
ATOM   1158 C  CB  . GLU A 1 142 ? -18.08  -34.1   25.828  1    49.76  ? 138 GLU A CB  1 
ATOM   1159 C  CG  . GLU A 1 142 ? -18.299 -33.568 27.238  1    50.24  ? 138 GLU A CG  1 
ATOM   1160 C  CD  . GLU A 1 142 ? -18.734 -34.671 28.179  1    54.87  ? 138 GLU A CD  1 
ATOM   1161 O  OE1 . GLU A 1 142 ? -19.83  -35.224 27.964  1    60.08  ? 138 GLU A OE1 1 
ATOM   1162 O  OE2 . GLU A 1 142 ? -17.973 -34.979 29.118  1    66.62  ? 138 GLU A OE2 1 
ATOM   1163 N  N   . GLY A 1 143 ? -15.695 -35.449 23.641  1    35.18  ? 139 GLY A N   1 
ATOM   1164 C  CA  . GLY A 1 143 ? -15.493 -36.102 22.338  1    32.33  ? 139 GLY A CA  1 
ATOM   1165 C  C   . GLY A 1 143 ? -15.672 -35.153 21.186  1    31.99  ? 139 GLY A C   1 
ATOM   1166 O  O   . GLY A 1 143 ? -15.709 -35.612 20.038  1    36.43  ? 139 GLY A O   1 
ATOM   1167 N  N   . ALA A 1 144 ? -15.765 -33.869 21.489  1    28.69  ? 140 ALA A N   1 
ATOM   1168 C  CA  . ALA A 1 144 ? -15.972 -32.865 20.436  1    26.6   ? 140 ALA A CA  1 
ATOM   1169 C  C   . ALA A 1 144 ? -14.65  -32.26  19.995  1    30.83  ? 140 ALA A C   1 
ATOM   1170 O  O   . ALA A 1 144 ? -13.726 -32.151 20.808  1    35.9   ? 140 ALA A O   1 
ATOM   1171 C  CB  . ALA A 1 144 ? -16.885 -31.791 20.942  1    22.51  ? 140 ALA A CB  1 
ATOM   1172 N  N   . ILE A 1 145 ? -14.575 -31.9   18.725  1    29.62  ? 141 ILE A N   1 
ATOM   1173 C  CA  . ILE A 1 145 ? -13.402 -31.19  18.218  1    29.87  ? 141 ILE A CA  1 
ATOM   1174 C  C   . ILE A 1 145 ? -13.877 -29.972 17.427  1    30.98  ? 141 ILE A C   1 
ATOM   1175 O  O   . ILE A 1 145 ? -14.886 -30.03  16.736  1    29.65  ? 141 ILE A O   1 
ATOM   1176 C  CB  . ILE A 1 145 ? -12.515 -32.091 17.35   1    29.41  ? 141 ILE A CB  1 
ATOM   1177 C  CG1 . ILE A 1 145 ? -11.163 -31.422 16.999  1    33.51  ? 141 ILE A CG1 1 
ATOM   1178 C  CG2 . ILE A 1 145 ? -13.294 -32.492 16.088  1    30.72  ? 141 ILE A CG2 1 
ATOM   1179 C  CD1 . ILE A 1 145 ? -10.104 -32.335 16.381  1    27.12  ? 141 ILE A CD1 1 
ATOM   1180 N  N   . LYS A 1 146 ? -13.132 -28.861 17.52   1    32.06  ? 142 LYS A N   1 
ATOM   1181 C  CA  . LYS A 1 146 ? -13.647 -27.589 17.039  1    30     ? 142 LYS A CA  1 
ATOM   1182 C  C   . LYS A 1 146 ? -12.546 -26.816 16.341  1    29.07  ? 142 LYS A C   1 
ATOM   1183 O  O   . LYS A 1 146 ? -11.458 -26.7   16.879  1    33.61  ? 142 LYS A O   1 
ATOM   1184 C  CB  . LYS A 1 146 ? -14.213 -26.77  18.204  1    25.41  ? 142 LYS A CB  1 
ATOM   1185 C  CG  . LYS A 1 146 ? -15.292 -27.497 18.963  1    24.66  ? 142 LYS A CG  1 
ATOM   1186 C  CD  . LYS A 1 146 ? -16.156 -26.56  19.812  1    32.54  ? 142 LYS A CD  1 
ATOM   1187 C  CE  . LYS A 1 146 ? -16.99  -27.354 20.801  1    32     ? 142 LYS A CE  1 
ATOM   1188 N  NZ  . LYS A 1 146 ? -18.221 -26.654 21.171  1    31.53  ? 142 LYS A NZ  1 
ATOM   1189 N  N   . LEU A 1 147 ? -12.855 -26.297 15.154  1    32.31  ? 143 LEU A N   1 
ATOM   1190 C  CA  . LEU A 1 147 ? -11.978 -25.377 14.44   1    32.75  ? 143 LEU A CA  1 
ATOM   1191 C  C   . LEU A 1 147 ? -11.711 -24.196 15.353  1    35.61  ? 143 LEU A C   1 
ATOM   1192 O  O   . LEU A 1 147 ? -12.612 -23.706 16.018  1    35.22  ? 143 LEU A O   1 
ATOM   1193 C  CB  . LEU A 1 147 ? -12.564 -24.859 13.128  1    29.48  ? 143 LEU A CB  1 
ATOM   1194 C  CG  . LEU A 1 147 ? -13.094 -25.886 12.116  1    35.19  ? 143 LEU A CG  1 
ATOM   1195 C  CD1 . LEU A 1 147 ? -13.003 -25.24  10.761  1    36.68  ? 143 LEU A CD1 1 
ATOM   1196 C  CD2 . LEU A 1 147 ? -12.405 -27.218 12.082  1    30.46  ? 143 LEU A CD2 1 
ATOM   1197 N  N   . ALA A 1 148 ? -10.459 -23.742 15.375  1    37.44  ? 144 ALA A N   1 
ATOM   1198 C  CA  . ALA A 1 148 ? -10.13  -22.586 16.19   1    34.08  ? 144 ALA A CA  1 
ATOM   1199 C  C   . ALA A 1 148 ? -9.085  -21.76  15.458  1    33.6   ? 144 ALA A C   1 
ATOM   1200 O  O   . ALA A 1 148 ? -8.619  -22.145 14.368  1    32.97  ? 144 ALA A O   1 
ATOM   1201 C  CB  . ALA A 1 148 ? -9.712  -22.985 17.604  1    27.91  ? 144 ALA A CB  1 
ATOM   1202 N  N   . ASP A 1 149 ? -8.809  -20.608 16.071  1    31.78  ? 145 ASP A N   1 
ATOM   1203 C  CA  . ASP A 1 149 ? -7.862  -19.624 15.595  1    39.9   ? 145 ASP A CA  1 
ATOM   1204 C  C   . ASP A 1 149 ? -8.224  -19.127 14.199  1    36.39  ? 145 ASP A C   1 
ATOM   1205 O  O   . ASP A 1 149 ? -7.6    -19.548 13.235  1    35.69  ? 145 ASP A O   1 
ATOM   1206 C  CB  . ASP A 1 149 ? -6.409  -20.049 15.759  1    41.06  ? 145 ASP A CB  1 
ATOM   1207 C  CG  . ASP A 1 149 ? -5.442  -18.865 15.72   1    58.18  ? 145 ASP A CG  1 
ATOM   1208 O  OD1 . ASP A 1 149 ? -5.878  -17.678 15.41   1    45.47  ? 145 ASP A OD1 1 
ATOM   1209 O  OD2 . ASP A 1 149 ? -4.26   -19.115 16.024  1    72.64  ? 145 ASP A OD2 1 
ATOM   1210 N  N   . PHE A 1 150 ? -9.149  -18.16  14.133  1    32.98  ? 146 PHE A N   1 
ATOM   1211 C  CA  . PHE A 1 150 ? -9.609  -17.604 12.867  1    33.48  ? 146 PHE A CA  1 
ATOM   1212 C  C   . PHE A 1 150 ? -8.835  -16.34  12.487  1    33.42  ? 146 PHE A C   1 
ATOM   1213 O  O   . PHE A 1 150 ? -9.325  -15.525 11.707  1    34.92  ? 146 PHE A O   1 
ATOM   1214 C  CB  . PHE A 1 150 ? -11.116 -17.331 12.946  1    30.4   ? 146 PHE A CB  1 
ATOM   1215 C  CG  . PHE A 1 150 ? -11.932 -18.587 12.699  1    28.84  ? 146 PHE A CG  1 
ATOM   1216 C  CD1 . PHE A 1 150 ? -11.928 -19.62  13.632  1    27.18  ? 146 PHE A CD1 1 
ATOM   1217 C  CD2 . PHE A 1 150 ? -12.673 -18.74  11.526  1    27.47  ? 146 PHE A CD2 1 
ATOM   1218 C  CE1 . PHE A 1 150 ? -12.648 -20.778 13.395  1    25.2   ? 146 PHE A CE1 1 
ATOM   1219 C  CE2 . PHE A 1 150 ? -13.401 -19.898 11.308  1    24.63  ? 146 PHE A CE2 1 
ATOM   1220 C  CZ  . PHE A 1 150 ? -13.392 -20.905 12.247  1    23.82  ? 146 PHE A CZ  1 
ATOM   1221 N  N   . GLY A 1 151 ? -7.602  -16.199 12.981  1    35.8   ? 147 GLY A N   1 
ATOM   1222 C  CA  . GLY A 1 151 ? -6.872  -14.943 12.843  1    33.53  ? 147 GLY A CA  1 
ATOM   1223 C  C   . GLY A 1 151 ? -6.352  -14.738 11.427  1    33.02  ? 147 GLY A C   1 
ATOM   1224 O  O   . GLY A 1 151 ? -6.078  -13.613 11.044  1    33.8   ? 147 GLY A O   1 
ATOM   1225 N  N   . LEU A 1 152 ? -6.211  -15.845 10.68   1    36.82  ? 148 LEU A N   1 
ATOM   1226 C  CA  . LEU A 1 152 ? -5.809  -15.81  9.281   1    39.73  ? 148 LEU A CA  1 
ATOM   1227 C  C   . LEU A 1 152 ? -6.985  -16.036 8.337   1    31.87  ? 148 LEU A C   1 
ATOM   1228 O  O   . LEU A 1 152 ? -6.807  -16.123 7.135   1    36.35  ? 148 LEU A O   1 
ATOM   1229 C  CB  . LEU A 1 152 ? -4.697  -16.833 9.086   1    39.26  ? 148 LEU A CB  1 
ATOM   1230 C  CG  . LEU A 1 152 ? -3.464  -16.466 9.906   1    55.83  ? 148 LEU A CG  1 
ATOM   1231 C  CD1 . LEU A 1 152 ? -3.084  -17.637 10.786  1    65.58  ? 148 LEU A CD1 1 
ATOM   1232 C  CD2 . LEU A 1 152 ? -2.344  -15.966 9.039   1    51.23  ? 148 LEU A CD2 1 
ATOM   1233 N  N   . ALA A 1 153 ? -8.186  -16.102 8.882   1    28.34  ? 149 ALA A N   1 
ATOM   1234 C  CA  . ALA A 1 153 ? -9.349  -16.45  8.092   1    29.81  ? 149 ALA A CA  1 
ATOM   1235 C  C   . ALA A 1 153 ? -9.749  -15.242 7.233   1    31.54  ? 149 ALA A C   1 
ATOM   1236 O  O   . ALA A 1 153 ? -9.217  -14.132 7.412   1    31.12  ? 149 ALA A O   1 
ATOM   1237 C  CB  . ALA A 1 153 ? -10.438 -16.89  9.044   1    25.31  ? 149 ALA A CB  1 
ATOM   1238 N  N   . ARG A 1 154 ? -10.645 -15.482 6.269   1    29.08  ? 150 ARG A N   1 
ATOM   1239 C  CA  . ARG A 1 154 ? -11.038 -14.388 5.35    1    34.72  ? 150 ARG A CA  1 
ATOM   1240 C  C   . ARG A 1 154 ? -12.422 -14.592 4.736   1    34.81  ? 150 ARG A C   1 
ATOM   1241 O  O   . ARG A 1 154 ? -12.72  -15.714 4.298   1    36.91  ? 150 ARG A O   1 
ATOM   1242 C  CB  . ARG A 1 154 ? -10.108 -14.295 4.141   1    34.42  ? 150 ARG A CB  1 
ATOM   1243 C  CG  . ARG A 1 154 ? -9.815  -12.865 3.721   1    35.67  ? 150 ARG A CG  1 
ATOM   1244 C  CD  . ARG A 1 154 ? -9.243  -12.867 2.327   1    43.15  ? 150 ARG A CD  1 
ATOM   1245 N  NE  . ARG A 1 154 ? -9.842  -11.799 1.526   1    37.57  ? 150 ARG A NE  1 
ATOM   1246 C  CZ  . ARG A 1 154 ? -9.359  -10.576 1.431   1    38.17  ? 150 ARG A CZ  1 
ATOM   1247 N  NH1 . ARG A 1 154 ? -10.19  -9.559  1.372   1    35.35  ? 150 ARG A NH1 1 
ATOM   1248 N  NH2 . ARG A 1 154 ? -8.057  -10.372 1.387   1    41.71  ? 150 ARG A NH2 1 
ATOM   1249 N  N   . ALA A 1 155 ? -13.229 -13.523 4.706   1    30.93  ? 151 ALA A N   1 
ATOM   1250 C  CA  . ALA A 1 155 ? -14.501 -13.606 3.99    1    28.69  ? 151 ALA A CA  1 
ATOM   1251 C  C   . ALA A 1 155 ? -14.263 -13.566 2.477   1    26.7   ? 151 ALA A C   1 
ATOM   1252 O  O   . ALA A 1 155 ? -13.742 -12.579 1.963   1    27.21  ? 151 ALA A O   1 
ATOM   1253 C  CB  . ALA A 1 155 ? -15.405 -12.483 4.421   1    22.5   ? 151 ALA A CB  1 
ATOM   1254 N  N   . PHE A 1 156 ? -14.698 -14.608 1.765   1    25.07  ? 152 PHE A N   1 
ATOM   1255 C  CA  . PHE A 1 156 ? -14.534 -14.617 0.319   1    28.93  ? 152 PHE A CA  1 
ATOM   1256 C  C   . PHE A 1 156 ? -15.821 -14.207 -0.387  1    34.46  ? 152 PHE A C   1 
ATOM   1257 O  O   . PHE A 1 156 ? -16.902 -14.196 0.214   1    32.69  ? 152 PHE A O   1 
ATOM   1258 C  CB  . PHE A 1 156 ? -14.037 -15.928 -0.28   1    29.28  ? 152 PHE A CB  1 
ATOM   1259 C  CG  . PHE A 1 156 ? -14.853 -17.192 -0.038  1    32.11  ? 152 PHE A CG  1 
ATOM   1260 C  CD1 . PHE A 1 156 ? -14.739 -17.893 1.178   1    31.39  ? 152 PHE A CD1 1 
ATOM   1261 C  CD2 . PHE A 1 156 ? -15.689 -17.69  -1.036  1    27.1   ? 152 PHE A CD2 1 
ATOM   1262 C  CE1 . PHE A 1 156 ? -15.464 -19.066 1.393   1    31.04  ? 152 PHE A CE1 1 
ATOM   1263 C  CE2 . PHE A 1 156 ? -16.4   -18.86  -0.82   1    30.45  ? 152 PHE A CE2 1 
ATOM   1264 C  CZ  . PHE A 1 156 ? -16.286 -19.562 0.385   1    28.9   ? 152 PHE A CZ  1 
ATOM   1265 N  N   . GLY A 1 157 ? -15.644 -13.808 -1.659  1    33.83  ? 153 GLY A N   1 
ATOM   1266 C  CA  . GLY A 1 157 ? -16.718 -13.59  -2.612  1    28.3   ? 153 GLY A CA  1 
ATOM   1267 C  C   . GLY A 1 157 ? -16.74  -14.696 -3.671  1    28.61  ? 153 GLY A C   1 
ATOM   1268 O  O   . GLY A 1 157 ? -15.81  -15.493 -3.791  1    31.88  ? 153 GLY A O   1 
ATOM   1269 N  N   . VAL A 1 158 ? -17.829 -14.721 -4.438  1    24.84  ? 154 VAL A N   1 
ATOM   1270 C  CA  . VAL A 1 158 ? -18.095 -15.718 -5.456  1    22.87  ? 154 VAL A CA  1 
ATOM   1271 C  C   . VAL A 1 158 ? -18.23  -14.985 -6.791  1    22.53  ? 154 VAL A C   1 
ATOM   1272 O  O   . VAL A 1 158 ? -19.11  -14.127 -6.917  1    18.01  ? 154 VAL A O   1 
ATOM   1273 C  CB  . VAL A 1 158 ? -19.411 -16.447 -5.107  1    24.25  ? 154 VAL A CB  1 
ATOM   1274 C  CG1 . VAL A 1 158 ? -19.769 -17.473 -6.176  1    24.84  ? 154 VAL A CG1 1 
ATOM   1275 C  CG2 . VAL A 1 158 ? -19.324 -17.14  -3.756  1    23.44  ? 154 VAL A CG2 1 
ATOM   1276 N  N   . PRO A 1 159 ? -17.326 -15.236 -7.784  1    24.1   ? 155 PRO A N   1 
ATOM   1277 C  CA  . PRO A 1 159 ? -16.136 -16.068 -7.576  1    23.83  ? 155 PRO A CA  1 
ATOM   1278 C  C   . PRO A 1 159 ? -15.089 -15.337 -6.726  1    29.1   ? 155 PRO A C   1 
ATOM   1279 O  O   . PRO A 1 159 ? -15.198 -14.113 -6.512  1    29.69  ? 155 PRO A O   1 
ATOM   1280 C  CB  . PRO A 1 159 ? -15.648 -16.303 -9.013  1    19.68  ? 155 PRO A CB  1 
ATOM   1281 C  CG  . PRO A 1 159 ? -16.026 -15.073 -9.753  1    19.66  ? 155 PRO A CG  1 
ATOM   1282 C  CD  . PRO A 1 159 ? -17.367 -14.653 -9.146  1    22.54  ? 155 PRO A CD  1 
ATOM   1283 N  N   . VAL A 1 160 ? -14.083 -16.095 -6.247  1    27.95  ? 156 VAL A N   1 
ATOM   1284 C  CA  . VAL A 1 160 ? -12.976 -15.548 -5.471  1    28.56  ? 156 VAL A CA  1 
ATOM   1285 C  C   . VAL A 1 160 ? -12.103 -14.611 -6.322  1    30.8   ? 156 VAL A C   1 
ATOM   1286 O  O   . VAL A 1 160 ? -11.974 -14.706 -7.551  1    29.54  ? 156 VAL A O   1 
ATOM   1287 C  CB  . VAL A 1 160 ? -12.086 -16.617 -4.818  1    27.91  ? 156 VAL A CB  1 
ATOM   1288 C  CG1 . VAL A 1 160 ? -12.852 -17.525 -3.859  1    22.49  ? 156 VAL A CG1 1 
ATOM   1289 C  CG2 . VAL A 1 160 ? -11.335 -17.421 -5.887  1    23.18  ? 156 VAL A CG2 1 
ATOM   1290 N  N   . ARG A 1 161 ? -11.531 -13.62  -5.432  1    32.16  ? 157 ARG A N   1 
ATOM   1291 C  CA  . ARG A 1 161 ? -10.565 -12.665 -6.005  1    34.5   ? 157 ARG A CA  1 
ATOM   1292 C  C   . ARG A 1 161 ? -9.187  -13.197 -5.614  1    34.83  ? 157 ARG A C   1 
ATOM   1293 O  O   . ARG A 1 161 ? -9.127  -14.273 -5.003  1    31.06  ? 157 ARG A O   1 
ATOM   1294 C  CB  . ARG A 1 161 ? -10.775 -11.273 -5.406  1    28.39  ? 157 ARG A CB  1 
ATOM   1295 C  CG  . ARG A 1 161 ? -11.795 -10.368 -6.075  1    30.54  ? 157 ARG A CG  1 
ATOM   1296 C  CD  . ARG A 1 161 ? -11.742 -8.974  -5.472  1    28.74  ? 157 ARG A CD  1 
ATOM   1297 N  NE  . ARG A 1 161 ? -10.768 -8.848  -4.383  1    38.68  ? 157 ARG A NE  1 
ATOM   1298 C  CZ  . ARG A 1 161 ? -11.074 -8.473  -3.149  1    41.74  ? 157 ARG A CZ  1 
ATOM   1299 N  NH1 . ARG A 1 161 ? -10.164 -8.526  -2.197  1    41     ? 157 ARG A NH1 1 
ATOM   1300 N  NH2 . ARG A 1 161 ? -12.291 -8.05   -2.872  1    39.07  ? 157 ARG A NH2 1 
ATOM   1301 N  N   . THR A 1 162 ? -8.097  -12.54  -6.084  1    36.15  ? 158 THR A N   1 
ATOM   1302 C  CA  . THR A 1 162 ? -6.783  -12.874 -5.537  1    34.96  ? 158 THR A CA  1 
ATOM   1303 C  C   . THR A 1 162 ? -6.722  -12.462 -4.06   1    29.36  ? 158 THR A C   1 
ATOM   1304 O  O   . THR A 1 162 ? -6.905  -11.289 -3.752  1    27.84  ? 158 THR A O   1 
ATOM   1305 C  CB  . THR A 1 162 ? -5.685  -12.169 -6.345  1    34.64  ? 158 THR A CB  1 
ATOM   1306 O  OG1 . THR A 1 162 ? -5.768  -12.685 -7.671  1    42.78  ? 158 THR A OG1 1 
ATOM   1307 C  CG2 . THR A 1 162 ? -4.283  -12.424 -5.805  1    26.26  ? 158 THR A CG2 1 
ATOM   1308 N  N   . TYR A 1 163 ? -6.424  -13.414 -3.168  1    26.18  ? 159 TYR A N   1 
ATOM   1309 C  CA  . TYR A 1 163 ? -6.182  -13.067 -1.777  1    31.06  ? 159 TYR A CA  1 
ATOM   1310 C  C   . TYR A 1 163 ? -4.693  -13.181 -1.412  1    34.05  ? 159 TYR A C   1 
ATOM   1311 O  O   . TYR A 1 163 ? -3.83   -13.406 -2.25   1    28.43  ? 159 TYR A O   1 
ATOM   1312 C  CB  . TYR A 1 163 ? -7.078  -13.894 -0.85   1    35.04  ? 159 TYR A CB  1 
ATOM   1313 C  CG  . TYR A 1 163 ? -8.556  -13.859 -1.21   1    34.74  ? 159 TYR A CG  1 
ATOM   1314 C  CD1 . TYR A 1 163 ? -9.222  -12.66  -1.461  1    32.36  ? 159 TYR A CD1 1 
ATOM   1315 C  CD2 . TYR A 1 163 ? -9.256  -15.047 -1.375  1    33.99  ? 159 TYR A CD2 1 
ATOM   1316 C  CE1 . TYR A 1 163 ? -10.546 -12.653 -1.852  1    34.28  ? 159 TYR A CE1 1 
ATOM   1317 C  CE2 . TYR A 1 163 ? -10.579 -15.056 -1.777  1    34.6   ? 159 TYR A CE2 1 
ATOM   1318 C  CZ  . TYR A 1 163 ? -11.221 -13.854 -2.022  1    39.33  ? 159 TYR A CZ  1 
ATOM   1319 O  OH  . TYR A 1 163 ? -12.532 -13.907 -2.389  1    41.73  ? 159 TYR A OH  1 
HETATM 1320 N  N   . TPO A 1 164 ? -4.391  -12.991 -0.126  1    34.69  ? 160 TPO A N   1 
HETATM 1321 C  CA  . TPO A 1 164 ? -3.034  -13.053 0.374   1    33.79  ? 160 TPO A CA  1 
HETATM 1322 C  CB  . TPO A 1 164 ? -3.044  -12.853 1.898   1    32.67  ? 160 TPO A CB  1 
HETATM 1323 C  CG2 . TPO A 1 164 ? -1.666  -12.785 2.509   1    23.96  ? 160 TPO A CG2 1 
HETATM 1324 O  OG1 . TPO A 1 164 ? -3.685  -11.566 2.171   1    36.43  ? 160 TPO A OG1 1 
HETATM 1325 P  P   . TPO A 1 164 ? -5.116  -11.564 2.942   1    33.88  ? 160 TPO A P   1 
HETATM 1326 O  O1P . TPO A 1 164 ? -6.064  -12.341 2.033   1    33.43  ? 160 TPO A O1P 1 
HETATM 1327 O  O2P . TPO A 1 164 ? -5.422  -10.084 3.055   1    24.85  ? 160 TPO A O2P 1 
HETATM 1328 O  O3P . TPO A 1 164 ? -4.907  -12.304 4.263   1    27.56  ? 160 TPO A O3P 1 
HETATM 1329 C  C   . TPO A 1 164 ? -2.377  -14.384 -0.017  1    39.76  ? 160 TPO A C   1 
HETATM 1330 O  O   . TPO A 1 164 ? -2.939  -15.473 0.186   1    34.68  ? 160 TPO A O   1 
ATOM   1331 N  N   . HIS A 1 165 ? -1.153  -14.267 -0.546  1    40.84  ? 161 HIS A N   1 
ATOM   1332 C  CA  . HIS A 1 165 ? -0.316  -15.403 -0.891  1    44.16  ? 161 HIS A CA  1 
ATOM   1333 C  C   . HIS A 1 165 ? 0.341   -15.996 0.359   1    45.6   ? 161 HIS A C   1 
ATOM   1334 O  O   . HIS A 1 165 ? 0.5     -15.311 1.366   1    47.27  ? 161 HIS A O   1 
ATOM   1335 C  CB  . HIS A 1 165 ? 0.726   -14.958 -1.921  1    43.04  ? 161 HIS A CB  1 
ATOM   1336 C  CG  . HIS A 1 165 ? 1.546   -16.106 -2.398  1    69.41  ? 161 HIS A CG  1 
ATOM   1337 N  ND1 . HIS A 1 165 ? 1.047   -17.387 -2.544  1    67.74  ? 161 HIS A ND1 1 
ATOM   1338 C  CD2 . HIS A 1 165 ? 2.837   -16.17  -2.749  1    84.56  ? 161 HIS A CD2 1 
ATOM   1339 C  CE1 . HIS A 1 165 ? 2.011   -18.191 -2.96   1    65.41  ? 161 HIS A CE1 1 
ATOM   1340 N  NE2 . HIS A 1 165 ? 3.107   -17.468 -3.106  1    82.24  ? 161 HIS A NE2 1 
ATOM   1341 N  N   . GLU A 1 166 ? 0.764   -17.265 0.29    1    55.93  ? 162 GLU A N   1 
ATOM   1342 C  CA  . GLU A 1 166 ? 1.67    -17.834 1.291   1    85.16  ? 162 GLU A CA  1 
ATOM   1343 C  C   . GLU A 1 166 ? 0.983   -17.974 2.66    1    88.91  ? 162 GLU A C   1 
ATOM   1344 O  O   . GLU A 1 166 ? 1.659   -18.137 3.677   1    125.55 ? 162 GLU A O   1 
ATOM   1345 C  CB  . GLU A 1 166 ? 3.001   -17.068 1.386   1    94.57  ? 162 GLU A CB  1 
ATOM   1346 C  CG  . GLU A 1 166 ? 4.122   -17.62  0.504   1    98.35  ? 162 GLU A CG  1 
ATOM   1347 C  CD  . GLU A 1 166 ? 5.223   -16.666 0.049   1    88.91  ? 162 GLU A CD  1 
ATOM   1348 O  OE1 . GLU A 1 166 ? 5.645   -16.742 -1.131  1    97.97  ? 162 GLU A OE1 1 
ATOM   1349 O  OE2 . GLU A 1 166 ? 5.671   -15.847 0.868   1    82.15  ? 162 GLU A OE2 1 
ATOM   1350 N  N   . VAL A 1 167 ? -0.358  -17.876 2.68    1    59.53  ? 163 VAL A N   1 
ATOM   1351 C  CA  . VAL A 1 167 ? -1.219  -18.305 3.773   1    41.5   ? 163 VAL A CA  1 
ATOM   1352 C  C   . VAL A 1 167 ? -1.064  -19.812 3.994   1    37.85  ? 163 VAL A C   1 
ATOM   1353 O  O   . VAL A 1 167 ? -0.676  -20.558 3.089   1    35.89  ? 163 VAL A O   1 
ATOM   1354 C  CB  . VAL A 1 167 ? -2.69   -18.026 3.392   1    40.64  ? 163 VAL A CB  1 
ATOM   1355 C  CG1 . VAL A 1 167 ? -3.058  -16.561 3.555   1    39.61  ? 163 VAL A CG1 1 
ATOM   1356 C  CG2 . VAL A 1 167 ? -3.029  -18.507 1.977   1    30.86  ? 163 VAL A CG2 1 
ATOM   1357 N  N   . VAL A 1 168 ? -1.477  -20.251 5.19    1    29.98  ? 164 VAL A N   1 
ATOM   1358 C  CA  . VAL A 1 168 ? -1.465  -21.643 5.626   1    27.79  ? 164 VAL A CA  1 
ATOM   1359 C  C   . VAL A 1 168 ? -0.062  -21.999 6.109   1    33.86  ? 164 VAL A C   1 
ATOM   1360 O  O   . VAL A 1 168 ? 0.923   -21.75  5.416   1    40.22  ? 164 VAL A O   1 
ATOM   1361 C  CB  . VAL A 1 168 ? -1.947  -22.619 4.546   1    27.67  ? 164 VAL A CB  1 
ATOM   1362 C  CG1 . VAL A 1 168 ? -2.195  -24.002 5.134   1    27.55  ? 164 VAL A CG1 1 
ATOM   1363 C  CG2 . VAL A 1 168 ? -3.193  -22.1   3.808   1    23.41  ? 164 VAL A CG2 1 
ATOM   1364 N  N   . THR A 1 169 ? 0.042   -22.521 7.335   1    32.37  ? 165 THR A N   1 
ATOM   1365 C  CA  . THR A 1 169 ? 1.295   -23.099 7.796   1    32.49  ? 165 THR A CA  1 
ATOM   1366 C  C   . THR A 1 169 ? 1.784   -24.111 6.74    1    37.33  ? 165 THR A C   1 
ATOM   1367 O  O   . THR A 1 169 ? 1.011   -24.946 6.236   1    31.1   ? 165 THR A O   1 
ATOM   1368 C  CB  . THR A 1 169 ? 1.11    -23.742 9.182   1    30.47  ? 165 THR A CB  1 
ATOM   1369 O  OG1 . THR A 1 169 ? 0.669   -22.744 10.104  1    29.85  ? 165 THR A OG1 1 
ATOM   1370 C  CG2 . THR A 1 169 ? 2.351   -24.434 9.716   1    23.83  ? 165 THR A CG2 1 
ATOM   1371 N  N   . LEU A 1 170 ? 3.1     -24.041 6.458   1    32.85  ? 166 LEU A N   1 
ATOM   1372 C  CA  . LEU A 1 170 ? 3.732   -24.659 5.315   1    29.18  ? 166 LEU A CA  1 
ATOM   1373 C  C   . LEU A 1 170 ? 3.389   -26.141 5.229   1    33.1   ? 166 LEU A C   1 
ATOM   1374 O  O   . LEU A 1 170 ? 3.047   -26.614 4.156   1    35.06  ? 166 LEU A O   1 
ATOM   1375 C  CB  . LEU A 1 170 ? 5.239   -24.43  5.409   1    32.36  ? 166 LEU A CB  1 
ATOM   1376 C  CG  . LEU A 1 170 ? 6.1     -25.172 4.38    1    31.89  ? 166 LEU A CG  1 
ATOM   1377 C  CD1 . LEU A 1 170 ? 5.78    -24.641 2.999   1    35.26  ? 166 LEU A CD1 1 
ATOM   1378 C  CD2 . LEU A 1 170 ? 7.565   -25.023 4.685   1    23.96  ? 166 LEU A CD2 1 
ATOM   1379 N  N   . TRP A 1 171 ? 3.519   -26.893 6.334   1    30.93  ? 167 TRP A N   1 
ATOM   1380 C  CA  . TRP A 1 171 ? 3.273   -28.329 6.203   1    29.63  ? 167 TRP A CA  1 
ATOM   1381 C  C   . TRP A 1 171 ? 1.855   -28.633 5.711   1    32.87  ? 167 TRP A C   1 
ATOM   1382 O  O   . TRP A 1 171 ? 1.578   -29.766 5.319   1    36.02  ? 167 TRP A O   1 
ATOM   1383 C  CB  . TRP A 1 171 ? 3.525   -29.07  7.518   1    24.95  ? 167 TRP A CB  1 
ATOM   1384 C  CG  . TRP A 1 171 ? 4.955   -29.03  7.978   1    25.44  ? 167 TRP A CG  1 
ATOM   1385 C  CD1 . TRP A 1 171 ? 6.056   -28.531 7.32    1    23.48  ? 167 TRP A CD1 1 
ATOM   1386 C  CD2 . TRP A 1 171 ? 5.42    -29.525 9.239   1    20.55  ? 167 TRP A CD2 1 
ATOM   1387 N  NE1 . TRP A 1 171 ? 7.168   -28.678 8.098   1    22.19  ? 167 TRP A NE1 1 
ATOM   1388 C  CE2 . TRP A 1 171 ? 6.813   -29.283 9.278   1    21.69  ? 167 TRP A CE2 1 
ATOM   1389 C  CE3 . TRP A 1 171 ? 4.786   -30.139 10.316  1    22.51  ? 167 TRP A CE3 1 
ATOM   1390 C  CZ2 . TRP A 1 171 ? 7.606   -29.651 10.363  1    20.2   ? 167 TRP A CZ2 1 
ATOM   1391 C  CZ3 . TRP A 1 171 ? 5.568   -30.519 11.384  1    23.48  ? 167 TRP A CZ3 1 
ATOM   1392 C  CH2 . TRP A 1 171 ? 6.956   -30.254 11.418  1    21.24  ? 167 TRP A CH2 1 
ATOM   1393 N  N   . TYR A 1 172 ? 0.951   -27.644 5.786   1    28.5   ? 168 TYR A N   1 
ATOM   1394 C  CA  . TYR A 1 172 ? -0.467  -27.892 5.556   1    32.2   ? 168 TYR A CA  1 
ATOM   1395 C  C   . TYR A 1 172 ? -0.923  -27.176 4.278   1    34.78  ? 168 TYR A C   1 
ATOM   1396 O  O   . TYR A 1 172 ? -2.119  -27.182 3.96    1    33.25  ? 168 TYR A O   1 
ATOM   1397 C  CB  . TYR A 1 172 ? -1.301  -27.595 6.816   1    26.66  ? 168 TYR A CB  1 
ATOM   1398 C  CG  . TYR A 1 172 ? -0.823  -28.405 7.997   1    25.28  ? 168 TYR A CG  1 
ATOM   1399 C  CD1 . TYR A 1 172 ? -1.247  -29.714 8.184   1    26.87  ? 168 TYR A CD1 1 
ATOM   1400 C  CD2 . TYR A 1 172 ? 0.131   -27.893 8.878   1    25.85  ? 168 TYR A CD2 1 
ATOM   1401 C  CE1 . TYR A 1 172 ? -0.746  -30.494 9.232   1    27.05  ? 168 TYR A CE1 1 
ATOM   1402 C  CE2 . TYR A 1 172 ? 0.617   -28.646 9.938   1    24.41  ? 168 TYR A CE2 1 
ATOM   1403 C  CZ  . TYR A 1 172 ? 0.186   -29.954 10.11   1    26.27  ? 168 TYR A CZ  1 
ATOM   1404 O  OH  . TYR A 1 172 ? 0.694   -30.682 11.147  1    26.38  ? 168 TYR A OH  1 
ATOM   1405 N  N   . ARG A 1 173 ? 0.05    -26.59  3.545   1    28.72  ? 169 ARG A N   1 
ATOM   1406 C  CA  . ARG A 1 173 ? -0.267  -25.691 2.45    1    30.65  ? 169 ARG A CA  1 
ATOM   1407 C  C   . ARG A 1 173 ? -0.44   -26.493 1.165   1    33.57  ? 169 ARG A C   1 
ATOM   1408 O  O   . ARG A 1 173 ? 0.391   -27.357 0.854   1    33.73  ? 169 ARG A O   1 
ATOM   1409 C  CB  . ARG A 1 173 ? 0.832   -24.638 2.295   1    29.69  ? 169 ARG A CB  1 
ATOM   1410 C  CG  . ARG A 1 173 ? 0.509   -23.51  1.321   1    30.83  ? 169 ARG A CG  1 
ATOM   1411 C  CD  . ARG A 1 173 ? 1.677   -22.522 1.204   1    29.92  ? 169 ARG A CD  1 
ATOM   1412 N  NE  . ARG A 1 173 ? 2.013   -22.042 2.554   1    29.91  ? 169 ARG A NE  1 
ATOM   1413 C  CZ  . ARG A 1 173 ? 3.14    -21.45  2.92    1    28.9   ? 169 ARG A CZ  1 
ATOM   1414 N  NH1 . ARG A 1 173 ? 4.089   -21.124 2.06    1    28     ? 169 ARG A NH1 1 
ATOM   1415 N  NH2 . ARG A 1 173 ? 3.306   -21.175 4.176   1    29.6   ? 169 ARG A NH2 1 
ATOM   1416 N  N   . ALA A 1 174 ? -1.499  -26.127 0.424   1    26.74  ? 170 ALA A N   1 
ATOM   1417 C  CA  . ALA A 1 174 ? -1.901  -26.752 -0.828  1    27.49  ? 170 ALA A CA  1 
ATOM   1418 C  C   . ALA A 1 174 ? -0.969  -26.413 -1.985  1    27.72  ? 170 ALA A C   1 
ATOM   1419 O  O   . ALA A 1 174 ? -0.416  -25.308 -2.101  1    30.58  ? 170 ALA A O   1 
ATOM   1420 C  CB  . ALA A 1 174 ? -3.309  -26.308 -1.181  1    24.4   ? 170 ALA A CB  1 
ATOM   1421 N  N   . PRO A 1 175 ? -0.86   -27.334 -2.942  1    27.51  ? 171 PRO A N   1 
ATOM   1422 C  CA  . PRO A 1 175 ? 0.057   -27.144 -4.062  1    33.83  ? 171 PRO A CA  1 
ATOM   1423 C  C   . PRO A 1 175 ? -0.243  -25.864 -4.845  1    34.29  ? 171 PRO A C   1 
ATOM   1424 O  O   . PRO A 1 175 ? 0.678   -25.206 -5.354  1    31.87  ? 171 PRO A O   1 
ATOM   1425 C  CB  . PRO A 1 175 ? -0.026  -28.445 -4.909  1    31.68  ? 171 PRO A CB  1 
ATOM   1426 C  CG  . PRO A 1 175 ? -1.264  -29.131 -4.403  1    34.24  ? 171 PRO A CG  1 
ATOM   1427 C  CD  . PRO A 1 175 ? -1.558  -28.62  -2.973  1    28.9   ? 171 PRO A CD  1 
ATOM   1428 N  N   . GLU A 1 176 ? -1.533  -25.514 -4.939  1    32.04  ? 172 GLU A N   1 
ATOM   1429 C  CA  . GLU A 1 176 ? -1.896  -24.373 -5.756  1    34.49  ? 172 GLU A CA  1 
ATOM   1430 C  C   . GLU A 1 176 ? -1.364  -23.086 -5.119  1    35.11  ? 172 GLU A C   1 
ATOM   1431 O  O   . GLU A 1 176 ? -1.133  -22.09  -5.809  1    33.58  ? 172 GLU A O   1 
ATOM   1432 C  CB  . GLU A 1 176 ? -3.367  -24.385 -6.182  1    32.41  ? 172 GLU A CB  1 
ATOM   1433 C  CG  . GLU A 1 176 ? -4.396  -24.274 -5.072  1    28.64  ? 172 GLU A CG  1 
ATOM   1434 C  CD  . GLU A 1 176 ? -4.84   -25.578 -4.407  1    34.48  ? 172 GLU A CD  1 
ATOM   1435 O  OE1 . GLU A 1 176 ? -5.97   -25.611 -3.836  1    33.84  ? 172 GLU A OE1 1 
ATOM   1436 O  OE2 . GLU A 1 176 ? -4.047  -26.548 -4.412  1    32.27  ? 172 GLU A OE2 1 
ATOM   1437 N  N   . ILE A 1 177 ? -1.167  -23.106 -3.791  1    33.35  ? 173 ILE A N   1 
ATOM   1438 C  CA  . ILE A 1 177 ? -0.554  -21.95  -3.145  1    33.17  ? 173 ILE A CA  1 
ATOM   1439 C  C   . ILE A 1 177 ? 0.954   -21.988 -3.413  1    33.02  ? 173 ILE A C   1 
ATOM   1440 O  O   . ILE A 1 177 ? 1.552   -21     -3.85   1    28.9   ? 173 ILE A O   1 
ATOM   1441 C  CB  . ILE A 1 177 ? -0.915  -21.863 -1.652  1    31.34  ? 173 ILE A CB  1 
ATOM   1442 C  CG1 . ILE A 1 177 ? -2.431  -21.923 -1.447  1    32.98  ? 173 ILE A CG1 1 
ATOM   1443 C  CG2 . ILE A 1 177 ? -0.35   -20.588 -1.059  1    24.37  ? 173 ILE A CG2 1 
ATOM   1444 C  CD1 . ILE A 1 177 ? -2.863  -21.99  -0.002  1    28.95  ? 173 ILE A CD1 1 
ATOM   1445 N  N   . LEU A 1 178 ? 1.553   -23.168 -3.217  1    29.06  ? 174 LEU A N   1 
ATOM   1446 C  CA  . LEU A 1 178 ? 2.974   -23.312 -3.451  1    26.53  ? 174 LEU A CA  1 
ATOM   1447 C  C   . LEU A 1 178 ? 3.349   -22.91  -4.882  1    28.61  ? 174 LEU A C   1 
ATOM   1448 O  O   . LEU A 1 178 ? 4.434   -22.347 -5.075  1    29.32  ? 174 LEU A O   1 
ATOM   1449 C  CB  . LEU A 1 178 ? 3.382   -24.728 -3.088  1    25.69  ? 174 LEU A CB  1 
ATOM   1450 C  CG  . LEU A 1 178 ? 3.303   -25.075 -1.598  1    26.01  ? 174 LEU A CG  1 
ATOM   1451 C  CD1 . LEU A 1 178 ? 3.281   -26.581 -1.383  1    25.76  ? 174 LEU A CD1 1 
ATOM   1452 C  CD2 . LEU A 1 178 ? 4.465   -24.476 -0.867  1    21.21  ? 174 LEU A CD2 1 
ATOM   1453 N  N   . LEU A 1 179 ? 2.455   -23.132 -5.866  1    25.29  ? 175 LEU A N   1 
ATOM   1454 C  CA  . LEU A 1 179 ? 2.763   -22.808 -7.252  1    26.91  ? 175 LEU A CA  1 
ATOM   1455 C  C   . LEU A 1 179 ? 2.344   -21.378 -7.623  1    32.76  ? 175 LEU A C   1 
ATOM   1456 O  O   . LEU A 1 179 ? 2.418   -20.969 -8.794  1    31.96  ? 175 LEU A O   1 
ATOM   1457 C  CB  . LEU A 1 179 ? 2.157   -23.848 -8.185  1    22.92  ? 175 LEU A CB  1 
ATOM   1458 C  CG  . LEU A 1 179 ? 2.815   -25.224 -8.115  1    25.41  ? 175 LEU A CG  1 
ATOM   1459 C  CD1 . LEU A 1 179 ? 1.999   -26.218 -8.891  1    27.55  ? 175 LEU A CD1 1 
ATOM   1460 C  CD2 . LEU A 1 179 ? 4.229   -25.208 -8.667  1    23.19  ? 175 LEU A CD2 1 
ATOM   1461 N  N   . GLY A 1 180 ? 1.932   -20.593 -6.617  1    30.94  ? 176 GLY A N   1 
ATOM   1462 C  CA  . GLY A 1 180 ? 1.784   -19.163 -6.81   1    29.57  ? 176 GLY A CA  1 
ATOM   1463 C  C   . GLY A 1 180 ? 0.563   -18.806 -7.657  1    34.35  ? 176 GLY A C   1 
ATOM   1464 O  O   . GLY A 1 180 ? 0.562   -17.768 -8.321  1    33.79  ? 176 GLY A O   1 
ATOM   1465 N  N   . CYS A 1 181 ? -0.471  -19.663 -7.63   1    33.52  ? 177 CYS A N   1 
ATOM   1466 C  CA  . CYS A 1 181 ? -1.649  -19.485 -8.476  1    35.13  ? 177 CYS A CA  1 
ATOM   1467 C  C   . CYS A 1 181 ? -2.326  -18.147 -8.166  1    34.16  ? 177 CYS A C   1 
ATOM   1468 O  O   . CYS A 1 181 ? -2.305  -17.658 -7.023  1    30.47  ? 177 CYS A O   1 
ATOM   1469 C  CB  . CYS A 1 181 ? -2.592  -20.684 -8.37   1    39.3   ? 177 CYS A CB  1 
ATOM   1470 S  SG  . CYS A 1 181 ? -2.017  -22.116 -9.35   1    54.24  ? 177 CYS A SG  1 
ATOM   1471 N  N   . LYS A 1 182 ? -2.894  -17.538 -9.216  1    25.94  ? 178 LYS A N   1 
ATOM   1472 C  CA  . LYS A 1 182 ? -3.595  -16.278 -9.033  1    27.41  ? 178 LYS A CA  1 
ATOM   1473 C  C   . LYS A 1 182 ? -4.771  -16.434 -8.057  1    28.16  ? 178 LYS A C   1 
ATOM   1474 O  O   . LYS A 1 182 ? -5.037  -15.532 -7.269  1    30.74  ? 178 LYS A O   1 
ATOM   1475 C  CB  . LYS A 1 182 ? -3.992  -15.777 -10.422 1    30.15  ? 178 LYS A CB  1 
ATOM   1476 C  CG  . LYS A 1 182 ? -4.741  -14.462 -10.462 1    43.38  ? 178 LYS A CG  1 
ATOM   1477 C  CD  . LYS A 1 182 ? -5.174  -14.073 -11.879 1    54.3   ? 178 LYS A CD  1 
ATOM   1478 C  CE  . LYS A 1 182 ? -5.326  -12.569 -12.036 1    65.25  ? 178 LYS A CE  1 
ATOM   1479 N  NZ  . LYS A 1 182 ? -6.238  -12.15  -13.106 1    64.29  ? 178 LYS A NZ  1 
ATOM   1480 N  N   . TYR A 1 183 ? -5.496  -17.564 -8.127  1    28.28  ? 179 TYR A N   1 
ATOM   1481 C  CA  . TYR A 1 183 ? -6.704  -17.769 -7.336  1    30.23  ? 179 TYR A CA  1 
ATOM   1482 C  C   . TYR A 1 183 ? -6.629  -19.07  -6.539  1    29.52  ? 179 TYR A C   1 
ATOM   1483 O  O   . TYR A 1 183 ? -6.138  -20.097 -7.024  1    29.59  ? 179 TYR A O   1 
ATOM   1484 C  CB  . TYR A 1 183 ? -7.919  -17.949 -8.244  1    30.82  ? 179 TYR A CB  1 
ATOM   1485 C  CG  . TYR A 1 183 ? -8.238  -16.741 -9.094  1    27.57  ? 179 TYR A CG  1 
ATOM   1486 C  CD1 . TYR A 1 183 ? -8.479  -15.506 -8.492  1    28.72  ? 179 TYR A CD1 1 
ATOM   1487 C  CD2 . TYR A 1 183 ? -8.283  -16.849 -10.482 1    23.17  ? 179 TYR A CD2 1 
ATOM   1488 C  CE1 . TYR A 1 183 ? -8.772  -14.396 -9.274  1    30.58  ? 179 TYR A CE1 1 
ATOM   1489 C  CE2 . TYR A 1 183 ? -8.564  -15.75  -11.269 1    25.5   ? 179 TYR A CE2 1 
ATOM   1490 C  CZ  . TYR A 1 183 ? -8.808  -14.528 -10.657 1    30.56  ? 179 TYR A CZ  1 
ATOM   1491 O  OH  . TYR A 1 183 ? -9.112  -13.436 -11.401 1    34.48  ? 179 TYR A OH  1 
ATOM   1492 N  N   . TYR A 1 184 ? -7.128  -18.993 -5.305  1    26.72  ? 180 TYR A N   1 
ATOM   1493 C  CA  . TYR A 1 184 ? -7.296  -20.179 -4.486  1    30.72  ? 180 TYR A CA  1 
ATOM   1494 C  C   . TYR A 1 184 ? -8.665  -20.068 -3.804  1    33.46  ? 180 TYR A C   1 
ATOM   1495 O  O   . TYR A 1 184 ? -9.22   -18.965 -3.687  1    32.02  ? 180 TYR A O   1 
ATOM   1496 C  CB  . TYR A 1 184 ? -6.113  -20.464 -3.548  1    27.84  ? 180 TYR A CB  1 
ATOM   1497 C  CG  . TYR A 1 184 ? -5.953  -19.432 -2.433  1    29.78  ? 180 TYR A CG  1 
ATOM   1498 C  CD1 . TYR A 1 184 ? -6.832  -19.376 -1.339  1    24.4   ? 180 TYR A CD1 1 
ATOM   1499 C  CD2 . TYR A 1 184 ? -4.891  -18.536 -2.466  1    27.31  ? 180 TYR A CD2 1 
ATOM   1500 C  CE1 . TYR A 1 184 ? -6.662  -18.438 -0.334  1    27.1   ? 180 TYR A CE1 1 
ATOM   1501 C  CE2 . TYR A 1 184 ? -4.707  -17.599 -1.458  1    29.81  ? 180 TYR A CE2 1 
ATOM   1502 C  CZ  . TYR A 1 184 ? -5.59   -17.547 -0.389  1    31.2   ? 180 TYR A CZ  1 
ATOM   1503 O  OH  . TYR A 1 184 ? -5.36   -16.581 0.555   1    32.39  ? 180 TYR A OH  1 
ATOM   1504 N  N   . SER A 1 185 ? -9.2    -21.234 -3.4    1    28.15  ? 181 SER A N   1 
ATOM   1505 C  CA  . SER A 1 185 ? -10.567 -21.32  -2.945  1    33.22  ? 181 SER A CA  1 
ATOM   1506 C  C   . SER A 1 185 ? -10.671 -22.29  -1.784  1    33.87  ? 181 SER A C   1 
ATOM   1507 O  O   . SER A 1 185 ? -9.689  -22.55  -1.09   1    38.34  ? 181 SER A O   1 
ATOM   1508 C  CB  . SER A 1 185 ? -11.518 -21.683 -4.069  1    32.51  ? 181 SER A CB  1 
ATOM   1509 O  OG  . SER A 1 185 ? -12.864 -21.548 -3.63   1    31.47  ? 181 SER A OG  1 
ATOM   1510 N  N   . THR A 1 186 ? -11.881 -22.821 -1.614  1    33.01  ? 182 THR A N   1 
ATOM   1511 C  CA  . THR A 1 186 ? -12.273 -23.572 -0.433  1    30.28  ? 182 THR A CA  1 
ATOM   1512 C  C   . THR A 1 186 ? -11.454 -24.845 -0.347  1    33.09  ? 182 THR A C   1 
ATOM   1513 O  O   . THR A 1 186 ? -11.326 -25.41  0.729   1    34.53  ? 182 THR A O   1 
ATOM   1514 C  CB  . THR A 1 186 ? -13.765 -23.879 -0.544  1    30.54  ? 182 THR A CB  1 
ATOM   1515 O  OG1 . THR A 1 186 ? -14.029 -24.408 -1.854  1    34.06  ? 182 THR A OG1 1 
ATOM   1516 C  CG2 . THR A 1 186 ? -14.606 -22.636 -0.311  1    22.46  ? 182 THR A CG2 1 
ATOM   1517 N  N   . ALA A 1 187 ? -10.906 -25.272 -1.497  1    36.53  ? 183 ALA A N   1 
ATOM   1518 C  CA  . ALA A 1 187 ? -10.145 -26.501 -1.62   1    30.73  ? 183 ALA A CA  1 
ATOM   1519 C  C   . ALA A 1 187 ? -8.848  -26.441 -0.805  1    34.03  ? 183 ALA A C   1 
ATOM   1520 O  O   . ALA A 1 187 ? -8.297  -27.487 -0.456  1    32.97  ? 183 ALA A O   1 
ATOM   1521 C  CB  . ALA A 1 187 ? -9.882  -26.788 -3.066  1    28.72  ? 183 ALA A CB  1 
ATOM   1522 N  N   . VAL A 1 188 ? -8.349  -25.233 -0.501  1    30.75  ? 184 VAL A N   1 
ATOM   1523 C  CA  . VAL A 1 188 ? -7.102  -25.163 0.249   1    34.03  ? 184 VAL A CA  1 
ATOM   1524 C  C   . VAL A 1 188 ? -7.336  -25.683 1.676   1    37.46  ? 184 VAL A C   1 
ATOM   1525 O  O   . VAL A 1 188 ? -6.429  -26.265 2.274   1    37.15  ? 184 VAL A O   1 
ATOM   1526 C  CB  . VAL A 1 188 ? -6.425  -23.779 0.266   1    30.24  ? 184 VAL A CB  1 
ATOM   1527 C  CG1 . VAL A 1 188 ? -6.433  -23.114 -1.099  1    24     ? 184 VAL A CG1 1 
ATOM   1528 C  CG2 . VAL A 1 188 ? -7.023  -22.86  1.336   1    30.39  ? 184 VAL A CG2 1 
ATOM   1529 N  N   . ASP A 1 189 ? -8.559  -25.47  2.213   1    34.37  ? 185 ASP A N   1 
ATOM   1530 C  CA  . ASP A 1 189 ? -8.916  -25.942 3.538   1    31.19  ? 185 ASP A CA  1 
ATOM   1531 C  C   . ASP A 1 189 ? -9.068  -27.463 3.505   1    32.51  ? 185 ASP A C   1 
ATOM   1532 O  O   . ASP A 1 189 ? -8.707  -28.14  4.463   1    37.08  ? 185 ASP A O   1 
ATOM   1533 C  CB  . ASP A 1 189 ? -10.133 -25.234 4.124   1    34.4   ? 185 ASP A CB  1 
ATOM   1534 C  CG  . ASP A 1 189 ? -9.956  -23.786 4.572   1    36.64  ? 185 ASP A CG  1 
ATOM   1535 O  OD1 . ASP A 1 189 ? -8.802  -23.387 4.86    1    32.94  ? 185 ASP A OD1 1 
ATOM   1536 O  OD2 . ASP A 1 189 ? -10.984 -23.035 4.605   1    39.22  ? 185 ASP A OD2 1 
ATOM   1537 N  N   . ILE A 1 190 ? -9.56   -28.021 2.394   1    29.29  ? 186 ILE A N   1 
ATOM   1538 C  CA  . ILE A 1 190 ? -9.664  -29.47  2.314   1    30.83  ? 186 ILE A CA  1 
ATOM   1539 C  C   . ILE A 1 190 ? -8.268  -30.106 2.298   1    33.09  ? 186 ILE A C   1 
ATOM   1540 O  O   . ILE A 1 190 ? -8.007  -31.126 2.951   1    32.78  ? 186 ILE A O   1 
ATOM   1541 C  CB  . ILE A 1 190 ? -10.532 -29.895 1.122   1    31.7   ? 186 ILE A CB  1 
ATOM   1542 C  CG1 . ILE A 1 190 ? -12.019 -29.677 1.436   1    34.24  ? 186 ILE A CG1 1 
ATOM   1543 C  CG2 . ILE A 1 190 ? -10.277 -31.355 0.766   1    30.23  ? 186 ILE A CG2 1 
ATOM   1544 C  CD1 . ILE A 1 190 ? -12.562 -30.532 2.576   1    33.66  ? 186 ILE A CD1 1 
ATOM   1545 N  N   . TRP A 1 191 ? -7.348  -29.482 1.567   1    33.1   ? 187 TRP A N   1 
ATOM   1546 C  CA  . TRP A 1 191 ? -6      -30.01  1.517   1    33.98  ? 187 TRP A CA  1 
ATOM   1547 C  C   . TRP A 1 191 ? -5.449  -30.131 2.936   1    31.39  ? 187 TRP A C   1 
ATOM   1548 O  O   . TRP A 1 191 ? -4.995  -31.193 3.335   1    36.24  ? 187 TRP A O   1 
ATOM   1549 C  CB  . TRP A 1 191 ? -5.098  -29.165 0.603   1    31.27  ? 187 TRP A CB  1 
ATOM   1550 C  CG  . TRP A 1 191 ? -3.698  -29.701 0.585   1    31.82  ? 187 TRP A CG  1 
ATOM   1551 C  CD1 . TRP A 1 191 ? -2.719  -29.495 1.516   1    30.95  ? 187 TRP A CD1 1 
ATOM   1552 C  CD2 . TRP A 1 191 ? -3.137  -30.576 -0.405  1    31.76  ? 187 TRP A CD2 1 
ATOM   1553 N  NE1 . TRP A 1 191 ? -1.585  -30.17  1.166   1    28.54  ? 187 TRP A NE1 1 
ATOM   1554 C  CE2 . TRP A 1 191 ? -1.81   -30.832 -0.011  1    30.61  ? 187 TRP A CE2 1 
ATOM   1555 C  CE3 . TRP A 1 191 ? -3.61   -31.135 -1.59   1    32.72  ? 187 TRP A CE3 1 
ATOM   1556 C  CZ2 . TRP A 1 191 ? -0.97   -31.632 -0.775  1    28.27  ? 187 TRP A CZ2 1 
ATOM   1557 C  CZ3 . TRP A 1 191 ? -2.754  -31.902 -2.353  1    31.5   ? 187 TRP A CZ3 1 
ATOM   1558 C  CH2 . TRP A 1 191 ? -1.455  -32.159 -1.948  1    23.7   ? 187 TRP A CH2 1 
ATOM   1559 N  N   . SER A 1 192 ? -5.543  -29.051 3.708   1    31.29  ? 188 SER A N   1 
ATOM   1560 C  CA  . SER A 1 192 ? -5.15   -29.082 5.11    1    32.98  ? 188 SER A CA  1 
ATOM   1561 C  C   . SER A 1 192 ? -5.805  -30.228 5.904   1    36.21  ? 188 SER A C   1 
ATOM   1562 O  O   . SER A 1 192 ? -5.113  -30.981 6.59    1    36.81  ? 188 SER A O   1 
ATOM   1563 C  CB  . SER A 1 192 ? -5.359  -27.734 5.733   1    31.98  ? 188 SER A CB  1 
ATOM   1564 O  OG  . SER A 1 192 ? -4.58   -26.751 5.057   1    33.45  ? 188 SER A OG  1 
ATOM   1565 N  N   . LEU A 1 193 ? -7.136  -30.401 5.809   1    37.69  ? 189 LEU A N   1 
ATOM   1566 C  CA  . LEU A 1 193 ? -7.787  -31.493 6.522   1    38.02  ? 189 LEU A CA  1 
ATOM   1567 C  C   . LEU A 1 193 ? -7.25   -32.848 6.058   1    36.67  ? 189 LEU A C   1 
ATOM   1568 O  O   . LEU A 1 193 ? -7.243  -33.812 6.822   1    34.43  ? 189 LEU A O   1 
ATOM   1569 C  CB  . LEU A 1 193 ? -9.296  -31.448 6.333   1    35.49  ? 189 LEU A CB  1 
ATOM   1570 C  CG  . LEU A 1 193 ? -10.013 -30.365 7.127   1    44.51  ? 189 LEU A CG  1 
ATOM   1571 C  CD1 . LEU A 1 193 ? -11.501 -30.727 7.169   1    40.05  ? 189 LEU A CD1 1 
ATOM   1572 C  CD2 . LEU A 1 193 ? -9.414  -30.279 8.533   1    41.57  ? 189 LEU A CD2 1 
ATOM   1573 N  N   . GLY A 1 194 ? -6.876  -32.932 4.78    1    30.51  ? 190 GLY A N   1 
ATOM   1574 C  CA  . GLY A 1 194 ? -6.301  -34.156 4.256   1    31.84  ? 190 GLY A CA  1 
ATOM   1575 C  C   . GLY A 1 194 ? -4.978  -34.488 4.954   1    30.61  ? 190 GLY A C   1 
ATOM   1576 O  O   . GLY A 1 194 ? -4.813  -35.585 5.483   1    30.23  ? 190 GLY A O   1 
ATOM   1577 N  N   . CYS A 1 195 ? -4.058  -33.518 5.007   1    29.52  ? 191 CYS A N   1 
ATOM   1578 C  CA  . CYS A 1 195 ? -2.806  -33.698 5.739   1    27.97  ? 191 CYS A CA  1 
ATOM   1579 C  C   . CYS A 1 195 ? -3.098  -34.113 7.183   1    29.92  ? 191 CYS A C   1 
ATOM   1580 O  O   . CYS A 1 195 ? -2.435  -35.003 7.703   1    27.44  ? 191 CYS A O   1 
ATOM   1581 C  CB  . CYS A 1 195 ? -2      -32.414 5.688   1    26.18  ? 191 CYS A CB  1 
ATOM   1582 S  SG  . CYS A 1 195 ? -1.55   -31.896 4.004   1    31.7   ? 191 CYS A SG  1 
ATOM   1583 N  N   . ILE A 1 196 ? -4.122  -33.496 7.812   1    28.94  ? 192 ILE A N   1 
ATOM   1584 C  CA  . ILE A 1 196 ? -4.453  -33.718 9.211   1    29.29  ? 192 ILE A CA  1 
ATOM   1585 C  C   . ILE A 1 196 ? -4.992  -35.128 9.43    1    32.27  ? 192 ILE A C   1 
ATOM   1586 O  O   . ILE A 1 196 ? -4.59   -35.793 10.4    1    28.09  ? 192 ILE A O   1 
ATOM   1587 C  CB  . ILE A 1 196 ? -5.423  -32.645 9.719   1    31.42  ? 192 ILE A CB  1 
ATOM   1588 C  CG1 . ILE A 1 196 ? -4.676  -31.312 9.778   1    33.55  ? 192 ILE A CG1 1 
ATOM   1589 C  CG2 . ILE A 1 196 ? -6.015  -33.029 11.082  1    25.36  ? 192 ILE A CG2 1 
ATOM   1590 C  CD1 . ILE A 1 196 ? -5.544  -30.09  9.956   1    30.7   ? 192 ILE A CD1 1 
ATOM   1591 N  N   . PHE A 1 197 ? -5.88   -35.562 8.508   1    32.94  ? 193 PHE A N   1 
ATOM   1592 C  CA  . PHE A 1 197 ? -6.395  -36.931 8.45    1    29.95  ? 193 PHE A CA  1 
ATOM   1593 C  C   . PHE A 1 197 ? -5.237  -37.926 8.529   1    29.46  ? 193 PHE A C   1 
ATOM   1594 O  O   . PHE A 1 197 ? -5.218  -38.797 9.411   1    32.9   ? 193 PHE A O   1 
ATOM   1595 C  CB  . PHE A 1 197 ? -7.251  -37.15  7.199   1    28.1   ? 193 PHE A CB  1 
ATOM   1596 C  CG  . PHE A 1 197 ? -7.863  -38.537 7.026   1    28.41  ? 193 PHE A CG  1 
ATOM   1597 C  CD1 . PHE A 1 197 ? -7.92   -39.457 8.082   1    23.7   ? 193 PHE A CD1 1 
ATOM   1598 C  CD2 . PHE A 1 197 ? -8.387  -38.917 5.785   1    27.3   ? 193 PHE A CD2 1 
ATOM   1599 C  CE1 . PHE A 1 197 ? -8.475  -40.719 7.882   1    24.96  ? 193 PHE A CE1 1 
ATOM   1600 C  CE2 . PHE A 1 197 ? -8.969  -40.174 5.6     1    25.64  ? 193 PHE A CE2 1 
ATOM   1601 C  CZ  . PHE A 1 197 ? -9.015  -41.076 6.648   1    25.05  ? 193 PHE A CZ  1 
ATOM   1602 N  N   . ALA A 1 198 ? -4.263  -37.764 7.625   1    26.82  ? 194 ALA A N   1 
ATOM   1603 C  CA  . ALA A 1 198 ? -3.105  -38.657 7.575   1    29.83  ? 194 ALA A CA  1 
ATOM   1604 C  C   . ALA A 1 198 ? -2.347  -38.59  8.897   1    30.24  ? 194 ALA A C   1 
ATOM   1605 O  O   . ALA A 1 198 ? -1.877  -39.626 9.385   1    34.14  ? 194 ALA A O   1 
ATOM   1606 C  CB  . ALA A 1 198 ? -2.215  -38.358 6.375   1    24.54  ? 194 ALA A CB  1 
ATOM   1607 N  N   . GLU A 1 199 ? -2.27   -37.377 9.468   1    27.79  ? 195 GLU A N   1 
ATOM   1608 C  CA  . GLU A 1 199 ? -1.426  -37.126 10.631  1    32.79  ? 195 GLU A CA  1 
ATOM   1609 C  C   . GLU A 1 199 ? -2.026  -37.802 11.872  1    39.05  ? 195 GLU A C   1 
ATOM   1610 O  O   . GLU A 1 199 ? -1.291  -38.287 12.749  1    36.39  ? 195 GLU A O   1 
ATOM   1611 C  CB  . GLU A 1 199 ? -1.146  -35.622 10.788  1    28.17  ? 195 GLU A CB  1 
ATOM   1612 C  CG  . GLU A 1 199 ? -0.222  -35.271 11.952  1    25.38  ? 195 GLU A CG  1 
ATOM   1613 C  CD  . GLU A 1 199 ? 0.271   -33.838 12.025  1    25.46  ? 195 GLU A CD  1 
ATOM   1614 O  OE1 . GLU A 1 199 ? 0.08    -33.17  10.988  1    25.53  ? 195 GLU A OE1 1 
ATOM   1615 O  OE2 . GLU A 1 199 ? 0.82    -33.387 13.095  1    28.01  ? 195 GLU A OE2 1 
ATOM   1616 N  N   . MET A 1 200 ? -3.367  -37.815 11.95   1    38.57  ? 196 MET A N   1 
ATOM   1617 C  CA  . MET A 1 200 ? -4.059  -38.521 13.025  1    34.41  ? 196 MET A CA  1 
ATOM   1618 C  C   . MET A 1 200 ? -3.76   -40.018 12.993  1    30.09  ? 196 MET A C   1 
ATOM   1619 O  O   . MET A 1 200 ? -3.707  -40.623 14.055  1    26.49  ? 196 MET A O   1 
ATOM   1620 C  CB  . MET A 1 200 ? -5.579  -38.289 12.966  1    33.22  ? 196 MET A CB  1 
ATOM   1621 C  CG  . MET A 1 200 ? -5.949  -36.9   13.39   1    29.96  ? 196 MET A CG  1 
ATOM   1622 S  SD  . MET A 1 200 ? -7.695  -36.697 13.724  1    31.41  ? 196 MET A SD  1 
ATOM   1623 C  CE  . MET A 1 200 ? -8.384  -36.817 12.075  1    32.76  ? 196 MET A CE  1 
ATOM   1624 N  N   . VAL A 1 201 ? -3.573  -40.601 11.792  1    30.18  ? 197 VAL A N   1 
ATOM   1625 C  CA  . VAL A 1 201 ? -3.334  -42.034 11.643  1    29.62  ? 197 VAL A CA  1 
ATOM   1626 C  C   . VAL A 1 201 ? -1.906  -42.401 12.07   1    32.83  ? 197 VAL A C   1 
ATOM   1627 O  O   . VAL A 1 201 ? -1.683  -43.405 12.758  1    33.85  ? 197 VAL A O   1 
ATOM   1628 C  CB  . VAL A 1 201 ? -3.634  -42.548 10.217  1    29.46  ? 197 VAL A CB  1 
ATOM   1629 C  CG1 . VAL A 1 201 ? -3.292  -44.019 10.092  1    31.17  ? 197 VAL A CG1 1 
ATOM   1630 C  CG2 . VAL A 1 201 ? -5.085  -42.359 9.784   1    28.01  ? 197 VAL A CG2 1 
ATOM   1631 N  N   . THR A 1 202 ? -0.933  -41.577 11.666  1    33.36  ? 198 THR A N   1 
ATOM   1632 C  CA  . THR A 1 202 ? 0.491   -41.864 11.846  1    35.11  ? 198 THR A CA  1 
ATOM   1633 C  C   . THR A 1 202 ? 1.058   -41.167 13.095  1    36.73  ? 198 THR A C   1 
ATOM   1634 O  O   . THR A 1 202 ? 2.08    -41.592 13.644  1    32.97  ? 198 THR A O   1 
ATOM   1635 C  CB  . THR A 1 202 ? 1.257   -41.443 10.584  1    38.1   ? 198 THR A CB  1 
ATOM   1636 O  OG1 . THR A 1 202 ? 1.306   -40.014 10.593  1    41.6   ? 198 THR A OG1 1 
ATOM   1637 C  CG2 . THR A 1 202 ? 0.615   -41.903 9.28    1    36.15  ? 198 THR A CG2 1 
ATOM   1638 N  N   . ARG A 1 203 ? 0.405   -40.078 13.527  1    39.55  ? 199 ARG A N   1 
ATOM   1639 C  CA  . ARG A 1 203 ? 0.963   -39.143 14.494  1    42.6   ? 199 ARG A CA  1 
ATOM   1640 C  C   . ARG A 1 203 ? 2.256   -38.523 13.964  1    39.03  ? 199 ARG A C   1 
ATOM   1641 O  O   . ARG A 1 203 ? 3.109   -38.137 14.744  1    41.7   ? 199 ARG A O   1 
ATOM   1642 C  CB  . ARG A 1 203 ? 1.221   -39.736 15.888  1    49.41  ? 199 ARG A CB  1 
ATOM   1643 C  CG  . ARG A 1 203 ? 0.018   -39.973 16.789  1    51.43  ? 199 ARG A CG  1 
ATOM   1644 C  CD  . ARG A 1 203 ? -0.528  -41.379 16.738  1    49.03  ? 199 ARG A CD  1 
ATOM   1645 N  NE  . ARG A 1 203 ? 0.452   -42.304 17.312  1    54.85  ? 199 ARG A NE  1 
ATOM   1646 C  CZ  . ARG A 1 203 ? 0.842   -43.458 16.759  1    61.03  ? 199 ARG A CZ  1 
ATOM   1647 N  NH1 . ARG A 1 203 ? 0.261   -43.887 15.632  1    49.94  ? 199 ARG A NH1 1 
ATOM   1648 N  NH2 . ARG A 1 203 ? 1.774   -44.198 17.368  1    57.86  ? 199 ARG A NH2 1 
ATOM   1649 N  N   . ARG A 1 204 ? 2.412   -38.396 12.645  1    36.2   ? 200 ARG A N   1 
ATOM   1650 C  CA  . ARG A 1 204 ? 3.532   -37.616 12.131  1    37.18  ? 200 ARG A CA  1 
ATOM   1651 C  C   . ARG A 1 204 ? 3.05    -36.812 10.927  1    32.25  ? 200 ARG A C   1 
ATOM   1652 O  O   . ARG A 1 204 ? 2.172   -37.269 10.211  1    34.33  ? 200 ARG A O   1 
ATOM   1653 C  CB  . ARG A 1 204 ? 4.736   -38.52  11.874  1    37.09  ? 200 ARG A CB  1 
ATOM   1654 C  CG  . ARG A 1 204 ? 4.74    -39.151 10.493  1    48.84  ? 200 ARG A CG  1 
ATOM   1655 C  CD  . ARG A 1 204 ? 5.613   -40.392 10.309  1    56.32  ? 200 ARG A CD  1 
ATOM   1656 N  NE  . ARG A 1 204 ? 5.484   -40.797 8.902   1    56.71  ? 200 ARG A NE  1 
ATOM   1657 C  CZ  . ARG A 1 204 ? 6.46    -41.278 8.137   1    59.15  ? 200 ARG A CZ  1 
ATOM   1658 N  NH1 . ARG A 1 204 ? 7.635   -41.583 8.667   1    60.82  ? 200 ARG A NH1 1 
ATOM   1659 N  NH2 . ARG A 1 204 ? 6.239   -41.495 6.854   1    49.04  ? 200 ARG A NH2 1 
ATOM   1660 N  N   . ALA A 1 205 ? 3.571   -35.6   10.732  1    32.11  ? 201 ALA A N   1 
ATOM   1661 C  CA  . ALA A 1 205 ? 3.116   -34.801 9.596   1    32.42  ? 201 ALA A CA  1 
ATOM   1662 C  C   . ALA A 1 205 ? 3.393   -35.547 8.287   1    32.74  ? 201 ALA A C   1 
ATOM   1663 O  O   . ALA A 1 205 ? 4.343   -36.32  8.194   1    32.38  ? 201 ALA A O   1 
ATOM   1664 C  CB  . ALA A 1 205 ? 3.776   -33.454 9.587   1    26.5   ? 201 ALA A CB  1 
ATOM   1665 N  N   . LEU A 1 206 ? 2.545   -35.31  7.294   1    29.15  ? 202 LEU A N   1 
ATOM   1666 C  CA  . LEU A 1 206 ? 2.619   -36.033 6.04    1    34.6   ? 202 LEU A CA  1 
ATOM   1667 C  C   . LEU A 1 206 ? 3.663   -35.399 5.125   1    31.16  ? 202 LEU A C   1 
ATOM   1668 O  O   . LEU A 1 206 ? 4.379   -36.1   4.44    1    35.7   ? 202 LEU A O   1 
ATOM   1669 C  CB  . LEU A 1 206 ? 1.236   -36.031 5.374   1    29.64  ? 202 LEU A CB  1 
ATOM   1670 C  CG  . LEU A 1 206 ? 1.113   -36.831 4.077   1    27.79  ? 202 LEU A CG  1 
ATOM   1671 C  CD1 . LEU A 1 206 ? 1.275   -38.306 4.388   1    27.66  ? 202 LEU A CD1 1 
ATOM   1672 C  CD2 . LEU A 1 206 ? -0.212  -36.558 3.39    1    28.52  ? 202 LEU A CD2 1 
ATOM   1673 N  N   . PHE A 1 207 ? 3.724   -34.073 5.092   1    28.82  ? 203 PHE A N   1 
ATOM   1674 C  CA  . PHE A 1 207 ? 4.706   -33.43  4.242   1    26.59  ? 203 PHE A CA  1 
ATOM   1675 C  C   . PHE A 1 207 ? 5.456   -32.361 5.032   1    29.72  ? 203 PHE A C   1 
ATOM   1676 O  O   . PHE A 1 207 ? 5.147   -31.175 4.918   1    40.71  ? 203 PHE A O   1 
ATOM   1677 C  CB  . PHE A 1 207 ? 3.947   -32.741 3.116   1    26.87  ? 203 PHE A CB  1 
ATOM   1678 C  CG  . PHE A 1 207 ? 3.009   -33.616 2.31    1    29.89  ? 203 PHE A CG  1 
ATOM   1679 C  CD1 . PHE A 1 207 ? 3.519   -34.677 1.551   1    28.77  ? 203 PHE A CD1 1 
ATOM   1680 C  CD2 . PHE A 1 207 ? 1.641   -33.307 2.243   1    27.02  ? 203 PHE A CD2 1 
ATOM   1681 C  CE1 . PHE A 1 207 ? 2.671   -35.45  0.768   1    30.95  ? 203 PHE A CE1 1 
ATOM   1682 C  CE2 . PHE A 1 207 ? 0.795   -34.074 1.444   1    28.33  ? 203 PHE A CE2 1 
ATOM   1683 C  CZ  . PHE A 1 207 ? 1.305   -35.143 0.696   1    29.38  ? 203 PHE A CZ  1 
ATOM   1684 N  N   . PRO A 1 208 ? 6.424   -32.723 5.903   1    26.32  ? 204 PRO A N   1 
ATOM   1685 C  CA  . PRO A 1 208 ? 7.124   -31.715 6.707   1    22.54  ? 204 PRO A CA  1 
ATOM   1686 C  C   . PRO A 1 208 ? 8.275   -31.064 5.951   1    23.58  ? 204 PRO A C   1 
ATOM   1687 O  O   . PRO A 1 208 ? 9.445   -31.371 6.225   1    22.5   ? 204 PRO A O   1 
ATOM   1688 C  CB  . PRO A 1 208 ? 7.673   -32.585 7.855   1    21.22  ? 204 PRO A CB  1 
ATOM   1689 C  CG  . PRO A 1 208 ? 7.992   -33.949 7.194   1    19.8   ? 204 PRO A CG  1 
ATOM   1690 C  CD  . PRO A 1 208 ? 6.896   -34.113 6.152   1    21.9   ? 204 PRO A CD  1 
ATOM   1691 N  N   . GLY A 1 209 ? 7.95    -30.183 5.003   1    21.67  ? 205 GLY A N   1 
ATOM   1692 C  CA  . GLY A 1 209 ? 8.995   -29.524 4.233   1    22.39  ? 205 GLY A CA  1 
ATOM   1693 C  C   . GLY A 1 209 ? 9.66    -28.414 5.04    1    25.52  ? 205 GLY A C   1 
ATOM   1694 O  O   . GLY A 1 209 ? 9.044   -27.897 5.961   1    29.39  ? 205 GLY A O   1 
ATOM   1695 N  N   . ASP A 1 210 ? 10.888  -28.016 4.675   1    28.79  ? 206 ASP A N   1 
ATOM   1696 C  CA  . ASP A 1 210 ? 11.58   -26.923 5.356   1    35.37  ? 206 ASP A CA  1 
ATOM   1697 C  C   . ASP A 1 210 ? 11.69   -25.685 4.463   1    33.37  ? 206 ASP A C   1 
ATOM   1698 O  O   . ASP A 1 210 ? 12.301  -24.708 4.865   1    36.41  ? 206 ASP A O   1 
ATOM   1699 C  CB  . ASP A 1 210 ? 12.895  -27.398 5.951   1    42.96  ? 206 ASP A CB  1 
ATOM   1700 C  CG  . ASP A 1 210 ? 13.833  -27.914 4.87    1    59.26  ? 206 ASP A CG  1 
ATOM   1701 O  OD1 . ASP A 1 210 ? 13.375  -27.946 3.703   1    73.03  ? 206 ASP A OD1 1 
ATOM   1702 O  OD2 . ASP A 1 210 ? 14.975  -28.352 5.208   1    49.04  ? 206 ASP A OD2 1 
ATOM   1703 N  N   . SER A 1 211 ? 11.046  -25.691 3.287   1    28.46  ? 207 SER A N   1 
ATOM   1704 C  CA  . SER A 1 211 ? 10.951  -24.504 2.446   1    25.68  ? 207 SER A CA  1 
ATOM   1705 C  C   . SER A 1 211 ? 9.829   -24.7   1.44    1    28.76  ? 207 SER A C   1 
ATOM   1706 O  O   . SER A 1 211 ? 9.284   -25.797 1.337   1    30.67  ? 207 SER A O   1 
ATOM   1707 C  CB  . SER A 1 211 ? 12.243  -24.232 1.739   1    27.97  ? 207 SER A CB  1 
ATOM   1708 O  OG  . SER A 1 211 ? 12.606  -25.318 0.909   1    30.36  ? 207 SER A OG  1 
ATOM   1709 N  N   . GLU A 1 212 ? 9.464   -23.649 0.693   1    29.31  ? 208 GLU A N   1 
ATOM   1710 C  CA  . GLU A 1 212 ? 8.395   -23.841 -0.28   1    30.51  ? 208 GLU A CA  1 
ATOM   1711 C  C   . GLU A 1 212 ? 8.771   -24.963 -1.257  1    28.64  ? 208 GLU A C   1 
ATOM   1712 O  O   . GLU A 1 212 ? 8.012   -25.885 -1.47   1    28.14  ? 208 GLU A O   1 
ATOM   1713 C  CB  . GLU A 1 212 ? 8.099   -22.543 -1.024  1    33.18  ? 208 GLU A CB  1 
ATOM   1714 C  CG  . GLU A 1 212 ? 7.289   -21.534 -0.217  1    35.4   ? 208 GLU A CG  1 
ATOM   1715 C  CD  . GLU A 1 212 ? 7.212   -20.186 -0.917  1    40.26  ? 208 GLU A CD  1 
ATOM   1716 O  OE1 . GLU A 1 212 ? 6.136   -19.876 -1.497  1    37.87  ? 208 GLU A OE1 1 
ATOM   1717 O  OE2 . GLU A 1 212 ? 8.239   -19.437 -0.894  1    41.49  ? 208 GLU A OE2 1 
ATOM   1718 N  N   . ILE A 1 213 ? 9.972   -24.923 -1.825  1    24.94  ? 209 ILE A N   1 
ATOM   1719 C  CA  . ILE A 1 213 ? 10.316  -25.889 -2.852  1    25.38  ? 209 ILE A CA  1 
ATOM   1720 C  C   . ILE A 1 213 ? 10.466  -27.313 -2.293  1    24.86  ? 209 ILE A C   1 
ATOM   1721 O  O   . ILE A 1 213 ? 10.067  -28.281 -2.941  1    27.96  ? 209 ILE A O   1 
ATOM   1722 C  CB  . ILE A 1 213 ? 11.554  -25.422 -3.641  1    23.12  ? 209 ILE A CB  1 
ATOM   1723 C  CG1 . ILE A 1 213 ? 11.691  -26.19  -4.936  1    22.13  ? 209 ILE A CG1 1 
ATOM   1724 C  CG2 . ILE A 1 213 ? 12.81   -25.509 -2.796  1    24.01  ? 209 ILE A CG2 1 
ATOM   1725 C  CD1 . ILE A 1 213 ? 10.575  -25.849 -5.925  1    20.99  ? 209 ILE A CD1 1 
ATOM   1726 N  N   . ASP A 1 214 ? 11.052  -27.45  -1.099  1    23.87  ? 210 ASP A N   1 
ATOM   1727 C  CA  . ASP A 1 214 ? 11.11   -28.722 -0.412  1    23.89  ? 210 ASP A CA  1 
ATOM   1728 C  C   . ASP A 1 214 ? 9.724   -29.304 -0.085  1    29.7   ? 210 ASP A C   1 
ATOM   1729 O  O   . ASP A 1 214 ? 9.513   -30.513 -0.15   1    35.09  ? 210 ASP A O   1 
ATOM   1730 C  CB  . ASP A 1 214 ? 11.896  -28.583 0.862   1    26.38  ? 210 ASP A CB  1 
ATOM   1731 C  CG  . ASP A 1 214 ? 12.05   -29.913 1.566   1    33.78  ? 210 ASP A CG  1 
ATOM   1732 O  OD1 . ASP A 1 214 ? 12.481  -30.892 0.871   1    38.42  ? 210 ASP A OD1 1 
ATOM   1733 O  OD2 . ASP A 1 214 ? 11.689  -29.962 2.766   1    31.41  ? 210 ASP A OD2 1 
ATOM   1734 N  N   . GLN A 1 215 ? 8.767   -28.446 0.281   1    28.08  ? 211 GLN A N   1 
ATOM   1735 C  CA  . GLN A 1 215 ? 7.389   -28.843 0.493   1    26.64  ? 211 GLN A CA  1 
ATOM   1736 C  C   . GLN A 1 215 ? 6.803   -29.425 -0.793  1    25.64  ? 211 GLN A C   1 
ATOM   1737 O  O   . GLN A 1 215 ? 6.224   -30.513 -0.757  1    24.78  ? 211 GLN A O   1 
ATOM   1738 C  CB  . GLN A 1 215 ? 6.559   -27.631 0.924   1    25.03  ? 211 GLN A CB  1 
ATOM   1739 C  CG  . GLN A 1 215 ? 5.156   -27.988 1.389   1    26.03  ? 211 GLN A CG  1 
ATOM   1740 C  CD  . GLN A 1 215 ? 5.24    -28.747 2.696   1    33.83  ? 211 GLN A CD  1 
ATOM   1741 O  OE1 . GLN A 1 215 ? 6.212   -28.592 3.448   1    34.17  ? 211 GLN A OE1 1 
ATOM   1742 N  NE2 . GLN A 1 215 ? 4.232   -29.563 2.98    1    28.65  ? 211 GLN A NE2 1 
ATOM   1743 N  N   . LEU A 1 216 ? 6.936   -28.69  -1.912  1    24.23  ? 212 LEU A N   1 
ATOM   1744 C  CA  . LEU A 1 216 ? 6.471   -29.155 -3.214  1    25.73  ? 212 LEU A CA  1 
ATOM   1745 C  C   . LEU A 1 216 ? 7.06    -30.517 -3.534  1    27.74  ? 212 LEU A C   1 
ATOM   1746 O  O   . LEU A 1 216 ? 6.322   -31.412 -3.932  1    26.48  ? 212 LEU A O   1 
ATOM   1747 C  CB  . LEU A 1 216 ? 6.893   -28.227 -4.339  1    27.91  ? 212 LEU A CB  1 
ATOM   1748 C  CG  . LEU A 1 216 ? 5.834   -27.257 -4.84   1    33.8   ? 212 LEU A CG  1 
ATOM   1749 C  CD1 . LEU A 1 216 ? 6.466   -26.643 -6.1    1    34.99  ? 212 LEU A CD1 1 
ATOM   1750 C  CD2 . LEU A 1 216 ? 4.482   -27.923 -5.08   1    25.19  ? 212 LEU A CD2 1 
ATOM   1751 N  N   . PHE A 1 217 ? 8.394   -30.617 -3.374  1    24.24  ? 213 PHE A N   1 
ATOM   1752 C  CA  . PHE A 1 217 ? 9.123   -31.812 -3.737  1    23.06  ? 213 PHE A CA  1 
ATOM   1753 C  C   . PHE A 1 217 ? 8.589   -32.983 -2.915  1    25.21  ? 213 PHE A C   1 
ATOM   1754 O  O   . PHE A 1 217 ? 8.301   -34.029 -3.482  1    29.79  ? 213 PHE A O   1 
ATOM   1755 C  CB  . PHE A 1 217 ? 10.629  -31.543 -3.723  1    20.92  ? 213 PHE A CB  1 
ATOM   1756 C  CG  . PHE A 1 217 ? 11.168  -30.791 -4.932  1    20.83  ? 213 PHE A CG  1 
ATOM   1757 C  CD1 . PHE A 1 217 ? 10.318  -30.251 -5.907  1    19.71  ? 213 PHE A CD1 1 
ATOM   1758 C  CD2 . PHE A 1 217 ? 12.537  -30.603 -5.09   1    21.3   ? 213 PHE A CD2 1 
ATOM   1759 C  CE1 . PHE A 1 217 ? 10.838  -29.577 -7.001  1    18.02  ? 213 PHE A CE1 1 
ATOM   1760 C  CE2 . PHE A 1 217 ? 13.058  -29.911 -6.194  1    18.87  ? 213 PHE A CE2 1 
ATOM   1761 C  CZ  . PHE A 1 217 ? 12.2    -29.388 -7.139  1    16.59  ? 213 PHE A CZ  1 
ATOM   1762 N  N   . ARG A 1 218 ? 8.373   -32.789 -1.612  1    23.93  ? 214 ARG A N   1 
ATOM   1763 C  CA  . ARG A 1 218 ? 7.872   -33.858 -0.759  1    28.2   ? 214 ARG A CA  1 
ATOM   1764 C  C   . ARG A 1 218 ? 6.478   -34.297 -1.215  1    27.16  ? 214 ARG A C   1 
ATOM   1765 O  O   . ARG A 1 218 ? 6.177   -35.487 -1.189  1    30.89  ? 214 ARG A O   1 
ATOM   1766 C  CB  . ARG A 1 218 ? 7.854   -33.437 0.729   1    29.97  ? 214 ARG A CB  1 
ATOM   1767 C  CG  . ARG A 1 218 ? 9.221   -33.462 1.407   1    33.1   ? 214 ARG A CG  1 
ATOM   1768 C  CD  . ARG A 1 218 ? 9.303   -32.63  2.665   1    28.73  ? 214 ARG A CD  1 
ATOM   1769 N  NE  . ARG A 1 218 ? 10.608  -32.615 3.348   1    27.17  ? 214 ARG A NE  1 
ATOM   1770 C  CZ  . ARG A 1 218 ? 11.02   -33.577 4.184   1    23.43  ? 214 ARG A CZ  1 
ATOM   1771 N  NH1 . ARG A 1 218 ? 10.338  -34.715 4.268   1    25.21  ? 214 ARG A NH1 1 
ATOM   1772 N  NH2 . ARG A 1 218 ? 12.08   -33.396 4.923   1    15.56  ? 214 ARG A NH2 1 
ATOM   1773 N  N   . ILE A 1 219 ? 5.621   -33.329 -1.57   1    23.77  ? 215 ILE A N   1 
ATOM   1774 C  CA  . ILE A 1 219 ? 4.292   -33.637 -2.059  1    26.99  ? 215 ILE A CA  1 
ATOM   1775 C  C   . ILE A 1 219 ? 4.418   -34.466 -3.329  1    29.02  ? 215 ILE A C   1 
ATOM   1776 O  O   . ILE A 1 219 ? 3.791   -35.52  -3.43   1    33.01  ? 215 ILE A O   1 
ATOM   1777 C  CB  . ILE A 1 219 ? 3.447   -32.371 -2.268  1    28.65  ? 215 ILE A CB  1 
ATOM   1778 C  CG1 . ILE A 1 219 ? 3.17    -31.658 -0.934  1    27.58  ? 215 ILE A CG1 1 
ATOM   1779 C  CG2 . ILE A 1 219 ? 2.129   -32.694 -2.971  1    23.91  ? 215 ILE A CG2 1 
ATOM   1780 C  CD1 . ILE A 1 219 ? 2.65    -30.246 -1.108  1    25.45  ? 215 ILE A CD1 1 
ATOM   1781 N  N   . PHE A 1 220 ? 5.255   -33.992 -4.26   1    26.85  ? 216 PHE A N   1 
ATOM   1782 C  CA  . PHE A 1 220 ? 5.441   -34.623 -5.554  1    26.47  ? 216 PHE A CA  1 
ATOM   1783 C  C   . PHE A 1 220 ? 6.016   -36.037 -5.439  1    27.62  ? 216 PHE A C   1 
ATOM   1784 O  O   . PHE A 1 220 ? 5.677   -36.893 -6.255  1    27.51  ? 216 PHE A O   1 
ATOM   1785 C  CB  . PHE A 1 220 ? 6.407   -33.834 -6.427  1    25.05  ? 216 PHE A CB  1 
ATOM   1786 C  CG  . PHE A 1 220 ? 5.95    -32.493 -6.978  1    22.45  ? 216 PHE A CG  1 
ATOM   1787 C  CD1 . PHE A 1 220 ? 4.726   -31.955 -6.655  1    22     ? 216 PHE A CD1 1 
ATOM   1788 C  CD2 . PHE A 1 220 ? 6.793   -31.767 -7.811  1    23.21  ? 216 PHE A CD2 1 
ATOM   1789 C  CE1 . PHE A 1 220 ? 4.348   -30.727 -7.179  1    24.3   ? 216 PHE A CE1 1 
ATOM   1790 C  CE2 . PHE A 1 220 ? 6.401   -30.556 -8.339  1    22.76  ? 216 PHE A CE2 1 
ATOM   1791 C  CZ  . PHE A 1 220 ? 5.195   -30.024 -8.004  1    22.38  ? 216 PHE A CZ  1 
ATOM   1792 N  N   . ARG A 1 221 ? 6.877   -36.263 -4.445  1    23.68  ? 217 ARG A N   1 
ATOM   1793 C  CA  . ARG A 1 221 ? 7.49    -37.604 -4.259  1    22.33  ? 217 ARG A CA  1 
ATOM   1794 C  C   . ARG A 1 221 ? 6.421   -38.582 -3.752  1    25.81  ? 217 ARG A C   1 
ATOM   1795 O  O   . ARG A 1 221 ? 6.556   -39.795 -4.019  1    27.79  ? 217 ARG A O   1 
ATOM   1796 C  CB  . ARG A 1 221 ? 8.656   -37.514 -3.27   1    21.35  ? 217 ARG A CB  1 
ATOM   1797 C  CG  . ARG A 1 221 ? 9.906   -36.915 -3.896  1    21.67  ? 217 ARG A CG  1 
ATOM   1798 C  CD  . ARG A 1 221 ? 11.005  -36.704 -2.874  1    23.96  ? 217 ARG A CD  1 
ATOM   1799 N  NE  . ARG A 1 221 ? 10.796  -35.486 -2.085  1    30.42  ? 217 ARG A NE  1 
ATOM   1800 C  CZ  . ARG A 1 221 ? 11.644  -34.468 -2.056  1    29.01  ? 217 ARG A CZ  1 
ATOM   1801 N  NH1 . ARG A 1 221 ? 11.62   -33.611 -1.052  1    25.75  ? 217 ARG A NH1 1 
ATOM   1802 N  NH2 . ARG A 1 221 ? 12.516  -34.311 -3.036  1    26.39  ? 217 ARG A NH2 1 
ATOM   1803 N  N   . THR A 1 222 ? 5.4     -38.072 -3.061  1    25.82  ? 218 THR A N   1 
ATOM   1804 C  CA  . THR A 1 222 ? 4.364   -38.923 -2.499  1    26.3   ? 218 THR A CA  1 
ATOM   1805 C  C   . THR A 1 222 ? 3.221   -39.163 -3.489  1    29.43  ? 218 THR A C   1 
ATOM   1806 O  O   . THR A 1 222 ? 2.72    -40.266 -3.593  1    38.92  ? 218 THR A O   1 
ATOM   1807 C  CB  . THR A 1 222 ? 3.796   -38.256 -1.256  1    29.13  ? 218 THR A CB  1 
ATOM   1808 O  OG1 . THR A 1 222 ? 4.869   -38.189 -0.322  1    29.12  ? 218 THR A OG1 1 
ATOM   1809 C  CG2 . THR A 1 222 ? 2.571   -38.988 -0.737  1    29.36  ? 218 THR A CG2 1 
ATOM   1810 N  N   . LEU A 1 223 ? 2.781   -38.12  -4.181  1    30.5   ? 219 LEU A N   1 
ATOM   1811 C  CA  . LEU A 1 223 ? 1.555   -38.166 -4.943  1    30.68  ? 219 LEU A CA  1 
ATOM   1812 C  C   . LEU A 1 223 ? 1.883   -38.178 -6.423  1    31.74  ? 219 LEU A C   1 
ATOM   1813 O  O   . LEU A 1 223 ? 0.961   -38.147 -7.25   1    34.12  ? 219 LEU A O   1 
ATOM   1814 C  CB  . LEU A 1 223 ? 0.78    -36.889 -4.604  1    31.93  ? 219 LEU A CB  1 
ATOM   1815 C  CG  . LEU A 1 223 ? 0.317   -36.779 -3.149  1    36.5   ? 219 LEU A CG  1 
ATOM   1816 C  CD1 . LEU A 1 223 ? -0.597  -35.587 -2.968  1    32.38  ? 219 LEU A CD1 1 
ATOM   1817 C  CD2 . LEU A 1 223 ? -0.386  -38.054 -2.7    1    35.15  ? 219 LEU A CD2 1 
ATOM   1818 N  N   . GLY A 1 224 ? 3.184   -38.102 -6.723  1    27.03  ? 220 GLY A N   1 
ATOM   1819 C  CA  . GLY A 1 224 ? 3.662   -38.024 -8.092  1    24.3   ? 220 GLY A CA  1 
ATOM   1820 C  C   . GLY A 1 224 ? 3.746   -36.577 -8.548  1    26.24  ? 220 GLY A C   1 
ATOM   1821 O  O   . GLY A 1 224 ? 2.986   -35.742 -8.061  1    21.91  ? 220 GLY A O   1 
ATOM   1822 N  N   . THR A 1 225 ? 4.695   -36.279 -9.465  1    27.34  ? 221 THR A N   1 
ATOM   1823 C  CA  . THR A 1 225 ? 4.807   -34.918 -9.98   1    26.96  ? 221 THR A CA  1 
ATOM   1824 C  C   . THR A 1 225 ? 3.624   -34.689 -10.914 1    31.72  ? 221 THR A C   1 
ATOM   1825 O  O   . THR A 1 225 ? 3.445   -35.44  -11.862 1    34.07  ? 221 THR A O   1 
ATOM   1826 C  CB  . THR A 1 225 ? 6.119   -34.679 -10.718 1    28.93  ? 221 THR A CB  1 
ATOM   1827 O  OG1 . THR A 1 225 ? 7.239   -34.952 -9.869  1    28.68  ? 221 THR A OG1 1 
ATOM   1828 C  CG2 . THR A 1 225 ? 6.191   -33.27  -11.277 1    24.25  ? 221 THR A CG2 1 
ATOM   1829 N  N   . PRO A 1 226 ? 2.754   -33.689 -10.676 1    30.73  ? 222 PRO A N   1 
ATOM   1830 C  CA  . PRO A 1 226 ? 1.581   -33.497 -11.536 1    30     ? 222 PRO A CA  1 
ATOM   1831 C  C   . PRO A 1 226 ? 1.962   -33.014 -12.932 1    28.67  ? 222 PRO A C   1 
ATOM   1832 O  O   . PRO A 1 226 ? 3.004   -32.39  -13.105 1    33.84  ? 222 PRO A O   1 
ATOM   1833 C  CB  . PRO A 1 226 ? 0.82    -32.404 -10.764 1    28.51  ? 222 PRO A CB  1 
ATOM   1834 C  CG  . PRO A 1 226 ? 1.941   -31.594 -10.114 1    28.29  ? 222 PRO A CG  1 
ATOM   1835 C  CD  . PRO A 1 226 ? 2.877   -32.691 -9.6    1    27.43  ? 222 PRO A CD  1 
ATOM   1836 N  N   . ASP A 1 227 ? 1.099   -33.31  -13.915 1    30.58  ? 223 ASP A N   1 
ATOM   1837 C  CA  . ASP A 1 227 ? 1.265   -32.92  -15.319 1    34.11  ? 223 ASP A CA  1 
ATOM   1838 C  C   . ASP A 1 227 ? -0.096  -32.46  -15.84  1    32.96  ? 223 ASP A C   1 
ATOM   1839 O  O   . ASP A 1 227 ? -1.061  -32.416 -15.067 1    26.01  ? 223 ASP A O   1 
ATOM   1840 C  CB  . ASP A 1 227 ? 1.763   -34.088 -16.167 1    31.29  ? 223 ASP A CB  1 
ATOM   1841 C  CG  . ASP A 1 227 ? 0.829   -35.286 -16.167 1    37.99  ? 223 ASP A CG  1 
ATOM   1842 O  OD1 . ASP A 1 227 ? -0.349  -35.131 -15.776 1    39.8   ? 223 ASP A OD1 1 
ATOM   1843 O  OD2 . ASP A 1 227 ? 1.273   -36.369 -16.541 1    47.68  ? 223 ASP A OD2 1 
ATOM   1844 N  N   . GLU A 1 228 ? -0.196  -32.232 -17.163 1    34.13  ? 224 GLU A N   1 
ATOM   1845 C  CA  . GLU A 1 228 ? -1.405  -31.63  -17.713 1    34.59  ? 224 GLU A CA  1 
ATOM   1846 C  C   . GLU A 1 228 ? -2.596  -32.584 -17.624 1    36.6   ? 224 GLU A C   1 
ATOM   1847 O  O   . GLU A 1 228 ? -3.743  -32.152 -17.468 1    36.09  ? 224 GLU A O   1 
ATOM   1848 C  CB  . GLU A 1 228 ? -1.167  -31.069 -19.101 1    30.2   ? 224 GLU A CB  1 
ATOM   1849 C  CG  . GLU A 1 228 ? -0.349  -29.783 -19.063 1    33.85  ? 224 GLU A CG  1 
ATOM   1850 C  CD  . GLU A 1 228 ? -1.132  -28.561 -18.606 1    41.72  ? 224 GLU A CD  1 
ATOM   1851 O  OE1 . GLU A 1 228 ? -2.386  -28.575 -18.698 1    38.18  ? 224 GLU A OE1 1 
ATOM   1852 O  OE2 . GLU A 1 228 ? -0.484  -27.6   -18.126 1    39.26  ? 224 GLU A OE2 1 
ATOM   1853 N  N   . VAL A 1 229 ? -2.315  -33.888 -17.657 1    34.29  ? 225 VAL A N   1 
ATOM   1854 C  CA  . VAL A 1 229 ? -3.398  -34.854 -17.586 1    36.39  ? 225 VAL A CA  1 
ATOM   1855 C  C   . VAL A 1 229 ? -4.035  -34.835 -16.198 1    37.05  ? 225 VAL A C   1 
ATOM   1856 O  O   . VAL A 1 229 ? -5.23   -34.661 -16.088 1    38.64  ? 225 VAL A O   1 
ATOM   1857 C  CB  . VAL A 1 229 ? -2.924  -36.263 -17.968 1    37.3   ? 225 VAL A CB  1 
ATOM   1858 C  CG1 . VAL A 1 229 ? -4.05   -37.27  -17.791 1    37.98  ? 225 VAL A CG1 1 
ATOM   1859 C  CG2 . VAL A 1 229 ? -2.34   -36.284 -19.379 1    38.91  ? 225 VAL A CG2 1 
ATOM   1860 N  N   . VAL A 1 230 ? -3.247  -35.015 -15.138 1    32.56  ? 226 VAL A N   1 
ATOM   1861 C  CA  . VAL A 1 230 ? -3.827  -35.067 -13.816 1    31.97  ? 226 VAL A CA  1 
ATOM   1862 C  C   . VAL A 1 230 ? -4.304  -33.671 -13.41  1    31.34  ? 226 VAL A C   1 
ATOM   1863 O  O   . VAL A 1 230 ? -5.268  -33.539 -12.657 1    34.36  ? 226 VAL A O   1 
ATOM   1864 C  CB  . VAL A 1 230 ? -2.828  -35.689 -12.811 1    35.05  ? 226 VAL A CB  1 
ATOM   1865 C  CG1 . VAL A 1 230 ? -1.542  -34.904 -12.776 1    44.33  ? 226 VAL A CG1 1 
ATOM   1866 C  CG2 . VAL A 1 230 ? -3.351  -35.746 -11.379 1    44.35  ? 226 VAL A CG2 1 
ATOM   1867 N  N   . TRP A 1 231 ? -3.639  -32.609 -13.87  1    30.2   ? 227 TRP A N   1 
ATOM   1868 C  CA  . TRP A 1 231 ? -4.007  -31.282 -13.386 1    31.76  ? 227 TRP A CA  1 
ATOM   1869 C  C   . TRP A 1 231 ? -3.914  -30.258 -14.521 1    32.09  ? 227 TRP A C   1 
ATOM   1870 O  O   . TRP A 1 231 ? -2.882  -29.637 -14.73  1    34.87  ? 227 TRP A O   1 
ATOM   1871 C  CB  . TRP A 1 231 ? -3.131  -30.915 -12.176 1    31.61  ? 227 TRP A CB  1 
ATOM   1872 C  CG  . TRP A 1 231 ? -3.464  -29.624 -11.476 1    33.92  ? 227 TRP A CG  1 
ATOM   1873 C  CD1 . TRP A 1 231 ? -4.502  -28.784 -11.732 1    35.7   ? 227 TRP A CD1 1 
ATOM   1874 C  CD2 . TRP A 1 231 ? -2.707  -29.011 -10.414 1    34.71  ? 227 TRP A CD2 1 
ATOM   1875 N  NE1 . TRP A 1 231 ? -4.45   -27.696 -10.905 1    37.43  ? 227 TRP A NE1 1 
ATOM   1876 C  CE2 . TRP A 1 231 ? -3.364  -27.811 -10.08  1    36.76  ? 227 TRP A CE2 1 
ATOM   1877 C  CE3 . TRP A 1 231 ? -1.555  -29.371 -9.701  1    35.06  ? 227 TRP A CE3 1 
ATOM   1878 C  CZ2 . TRP A 1 231 ? -2.921  -26.987 -9.047  1    32.46  ? 227 TRP A CZ2 1 
ATOM   1879 C  CZ3 . TRP A 1 231 ? -1.095  -28.552 -8.698  1    32.56  ? 227 TRP A CZ3 1 
ATOM   1880 C  CH2 . TRP A 1 231 ? -1.782  -27.384 -8.372  1    38.39  ? 227 TRP A CH2 1 
ATOM   1881 N  N   . PRO A 1 232 ? -4.966  -30.055 -15.336 1    37.76  ? 228 PRO A N   1 
ATOM   1882 C  CA  . PRO A 1 232 ? -4.854  -29.133 -16.481 1    35.94  ? 228 PRO A CA  1 
ATOM   1883 C  C   . PRO A 1 232 ? -4.529  -27.711 -16.01  1    32.63  ? 228 PRO A C   1 
ATOM   1884 O  O   . PRO A 1 232 ? -5.125  -27.263 -15.031 1    28.2   ? 228 PRO A O   1 
ATOM   1885 C  CB  . PRO A 1 232 ? -6.215  -29.229 -17.203 1    31.38  ? 228 PRO A CB  1 
ATOM   1886 C  CG  . PRO A 1 232 ? -6.87   -30.467 -16.606 1    32.5   ? 228 PRO A CG  1 
ATOM   1887 C  CD  . PRO A 1 232 ? -6.284  -30.708 -15.22  1    35.38  ? 228 PRO A CD  1 
ATOM   1888 N  N   . GLY A 1 233 ? -3.543  -27.056 -16.67  1    30.68  ? 229 GLY A N   1 
ATOM   1889 C  CA  . GLY A 1 233 ? -3.037  -25.742 -16.279 1    31.74  ? 229 GLY A CA  1 
ATOM   1890 C  C   . GLY A 1 233 ? -1.766  -25.754 -15.411 1    38.53  ? 229 GLY A C   1 
ATOM   1891 O  O   . GLY A 1 233 ? -1.049  -24.754 -15.343 1    44.22  ? 229 GLY A O   1 
ATOM   1892 N  N   . VAL A 1 234 ? -1.475  -26.869 -14.726 1    35.73  ? 230 VAL A N   1 
ATOM   1893 C  CA  . VAL A 1 234 ? -0.388  -26.896 -13.769 1    30.62  ? 230 VAL A CA  1 
ATOM   1894 C  C   . VAL A 1 234 ? 0.886   -26.356 -14.422 1    33.97  ? 230 VAL A C   1 
ATOM   1895 O  O   . VAL A 1 234 ? 1.582   -25.559 -13.827 1    39.01  ? 230 VAL A O   1 
ATOM   1896 C  CB  . VAL A 1 234 ? -0.199  -28.282 -13.146 1    28.33  ? 230 VAL A CB  1 
ATOM   1897 C  CG1 . VAL A 1 234 ? 0.412   -29.272 -14.128 1    28.78  ? 230 VAL A CG1 1 
ATOM   1898 C  CG2 . VAL A 1 234 ? 0.658   -28.22  -11.897 1    29.64  ? 230 VAL A CG2 1 
ATOM   1899 N  N   . THR A 1 235 ? 1.18    -26.75  -15.658 1    34.15  ? 231 THR A N   1 
ATOM   1900 C  CA  . THR A 1 235 ? 2.478   -26.386 -16.278 1    35.3   ? 231 THR A CA  1 
ATOM   1901 C  C   . THR A 1 235 ? 2.552   -24.914 -16.607 1    36.79  ? 231 THR A C   1 
ATOM   1902 O  O   . THR A 1 235 ? 3.661   -24.44  -16.893 1    40.76  ? 231 THR A O   1 
ATOM   1903 C  CB  . THR A 1 235 ? 2.746   -27.251 -17.508 1    30.62  ? 231 THR A CB  1 
ATOM   1904 O  OG1 . THR A 1 235 ? 1.787   -26.832 -18.471 1    36.43  ? 231 THR A OG1 1 
ATOM   1905 C  CG2 . THR A 1 235 ? 2.634   -28.734 -17.205 1    28.17  ? 231 THR A CG2 1 
ATOM   1906 N  N   . SER A 1 236 ? 1.425   -24.212 -16.578 1    36.13  ? 232 SER A N   1 
ATOM   1907 C  CA  . SER A 1 236 ? 1.421   -22.78  -16.956 1    42.46  ? 232 SER A CA  1 
ATOM   1908 C  C   . SER A 1 236 ? 1.284   -21.939 -15.69  1    44     ? 232 SER A C   1 
ATOM   1909 O  O   . SER A 1 236 ? 1.051   -20.729 -15.805 1    46.95  ? 232 SER A O   1 
ATOM   1910 C  CB  . SER A 1 236 ? 0.317   -22.466 -17.914 1    44.22  ? 232 SER A CB  1 
ATOM   1911 O  OG  . SER A 1 236 ? 0.763   -22.583 -19.257 1    56.75  ? 232 SER A OG  1 
ATOM   1912 N  N   . MET A 1 237 ? 1.442   -22.566 -14.533 1    44.03  ? 233 MET A N   1 
ATOM   1913 C  CA  . MET A 1 237 ? 1.204   -21.824 -13.275 1    39.21  ? 233 MET A CA  1 
ATOM   1914 C  C   . MET A 1 237 ? 2.45    -21.003 -12.928 1    32.87  ? 233 MET A C   1 
ATOM   1915 O  O   . MET A 1 237 ? 3.565   -21.449 -13.221 1    35.53  ? 233 MET A O   1 
ATOM   1916 C  CB  . MET A 1 237 ? 0.654   -22.773 -12.203 1    38.22  ? 233 MET A CB  1 
ATOM   1917 C  CG  . MET A 1 237 ? -0.843  -22.919 -12.39  1    46.72  ? 233 MET A CG  1 
ATOM   1918 S  SD  . MET A 1 237 ? -1.705  -24.347 -11.709 1    56.53  ? 233 MET A SD  1 
ATOM   1919 C  CE  . MET A 1 237 ? -0.354  -24.966 -10.709 1    69.92  ? 233 MET A CE  1 
ATOM   1920 N  N   . PRO A 1 238 ? 2.285   -19.809 -12.332 1    29.98  ? 234 PRO A N   1 
ATOM   1921 C  CA  . PRO A 1 238 ? 3.409   -18.909 -12.112 1    28.29  ? 234 PRO A CA  1 
ATOM   1922 C  C   . PRO A 1 238 ? 4.719   -19.459 -11.577 1    27.21  ? 234 PRO A C   1 
ATOM   1923 O  O   . PRO A 1 238 ? 5.776   -18.984 -12.006 1    33.38  ? 234 PRO A O   1 
ATOM   1924 C  CB  . PRO A 1 238 ? 2.739   -17.951 -11.118 1    26.74  ? 234 PRO A CB  1 
ATOM   1925 C  CG  . PRO A 1 238 ? 1.322   -17.857 -11.596 1    26.31  ? 234 PRO A CG  1 
ATOM   1926 C  CD  . PRO A 1 238 ? 1.014   -19.31  -11.84  1    28.08  ? 234 PRO A CD  1 
ATOM   1927 N  N   . ASP A 1 239 ? 4.661   -20.416 -10.661 1    24.85  ? 235 ASP A N   1 
ATOM   1928 C  CA  . ASP A 1 239 ? 5.907   -20.906 -10.024 1    29.12  ? 235 ASP A CA  1 
ATOM   1929 C  C   . ASP A 1 239 ? 6.169   -22.333 -10.493 1    31.88  ? 235 ASP A C   1 
ATOM   1930 O  O   . ASP A 1 239 ? 7.056   -22.972 -9.923  1    35.29  ? 235 ASP A O   1 
ATOM   1931 C  CB  . ASP A 1 239 ? 5.895   -20.598 -8.537  1    30.9   ? 235 ASP A CB  1 
ATOM   1932 C  CG  . ASP A 1 239 ? 5.91    -19.112 -8.219  1    34.54  ? 235 ASP A CG  1 
ATOM   1933 O  OD1 . ASP A 1 239 ? 6.724   -18.395 -8.829  1    39.39  ? 235 ASP A OD1 1 
ATOM   1934 O  OD2 . ASP A 1 239 ? 5.097   -18.679 -7.386  1    35.35  ? 235 ASP A OD2 1 
ATOM   1935 N  N   . TYR A 1 240 ? 5.402   -22.822 -11.467 1    31.35  ? 236 TYR A N   1 
ATOM   1936 C  CA  . TYR A 1 240 ? 5.763   -24.092 -12.069 1    33.29  ? 236 TYR A CA  1 
ATOM   1937 C  C   . TYR A 1 240 ? 7.064   -23.879 -12.836 1    28.69  ? 236 TYR A C   1 
ATOM   1938 O  O   . TYR A 1 240 ? 7.246   -22.85  -13.482 1    31.09  ? 236 TYR A O   1 
ATOM   1939 C  CB  . TYR A 1 240 ? 4.663   -24.627 -13     1    35.25  ? 236 TYR A CB  1 
ATOM   1940 C  CG  . TYR A 1 240 ? 5.057   -25.953 -13.643 1    37.27  ? 236 TYR A CG  1 
ATOM   1941 C  CD1 . TYR A 1 240 ? 4.81    -27.158 -12.99  1    39.18  ? 236 TYR A CD1 1 
ATOM   1942 C  CD2 . TYR A 1 240 ? 5.709   -26     -14.864 1    38.91  ? 236 TYR A CD2 1 
ATOM   1943 C  CE1 . TYR A 1 240 ? 5.198   -28.375 -13.518 1    42.34  ? 236 TYR A CE1 1 
ATOM   1944 C  CE2 . TYR A 1 240 ? 6.087   -27.218 -15.415 1    47.97  ? 236 TYR A CE2 1 
ATOM   1945 C  CZ  . TYR A 1 240 ? 5.851   -28.409 -14.739 1    50.5   ? 236 TYR A CZ  1 
ATOM   1946 O  OH  . TYR A 1 240 ? 6.226   -29.618 -15.29  1    56.48  ? 236 TYR A OH  1 
ATOM   1947 N  N   . LYS A 1 241 ? 7.955   -24.863 -12.78  1    28.48  ? 237 LYS A N   1 
ATOM   1948 C  CA  . LYS A 1 241 ? 9.176   -24.802 -13.581 1    29.17  ? 237 LYS A CA  1 
ATOM   1949 C  C   . LYS A 1 241 ? 9.277   -26.123 -14.334 1    25.11  ? 237 LYS A C   1 
ATOM   1950 O  O   . LYS A 1 241 ? 9.026   -27.172 -13.752 1    24.21  ? 237 LYS A O   1 
ATOM   1951 C  CB  . LYS A 1 241 ? 10.436  -24.536 -12.734 1    32.09  ? 237 LYS A CB  1 
ATOM   1952 C  CG  . LYS A 1 241 ? 10.443  -23.218 -11.966 1    41.81  ? 237 LYS A CG  1 
ATOM   1953 C  CD  . LYS A 1 241 ? 10.432  -21.971 -12.848 1    45.63  ? 237 LYS A CD  1 
ATOM   1954 C  CE  . LYS A 1 241 ? 10.517  -20.717 -11.96  1    56.13  ? 237 LYS A CE  1 
ATOM   1955 N  NZ  . LYS A 1 241 ? 10.499  -19.378 -12.6   1    61.31  ? 237 LYS A NZ  1 
ATOM   1956 N  N   . PRO A 1 242 ? 9.536   -26.114 -15.66  1    25.33  ? 238 PRO A N   1 
ATOM   1957 C  CA  . PRO A 1 242 ? 9.747   -27.358 -16.407 1    25.77  ? 238 PRO A CA  1 
ATOM   1958 C  C   . PRO A 1 242 ? 10.809  -28.295 -15.834 1    28.83  ? 238 PRO A C   1 
ATOM   1959 O  O   . PRO A 1 242 ? 10.686  -29.511 -15.968 1    31.89  ? 238 PRO A O   1 
ATOM   1960 C  CB  . PRO A 1 242 ? 10.108  -26.938 -17.849 1    24.56  ? 238 PRO A CB  1 
ATOM   1961 C  CG  . PRO A 1 242 ? 10.248  -25.417 -17.804 1    24.72  ? 238 PRO A CG  1 
ATOM   1962 C  CD  . PRO A 1 242 ? 9.602   -24.917 -16.507 1    23.88  ? 238 PRO A CD  1 
ATOM   1963 N  N   . SER A 1 243 ? 11.863  -27.724 -15.224 1    27.54  ? 239 SER A N   1 
ATOM   1964 C  CA  . SER A 1 243 ? 12.967  -28.493 -14.664 1    25.84  ? 239 SER A CA  1 
ATOM   1965 C  C   . SER A 1 243 ? 12.525  -29.313 -13.44  1    23.59  ? 239 SER A C   1 
ATOM   1966 O  O   . SER A 1 243 ? 13.304  -30.133 -12.979 1    20.08  ? 239 SER A O   1 
ATOM   1967 C  CB  . SER A 1 243 ? 14.126  -27.606 -14.336 1    25.19  ? 239 SER A CB  1 
ATOM   1968 O  OG  . SER A 1 243 ? 13.671  -26.581 -13.453 1    32.23  ? 239 SER A OG  1 
ATOM   1969 N  N   . PHE A 1 244 ? 11.286  -29.124 -12.947 1    22.09  ? 240 PHE A N   1 
ATOM   1970 C  CA  . PHE A 1 244 ? 10.772  -29.913 -11.844 1    22.52  ? 240 PHE A CA  1 
ATOM   1971 C  C   . PHE A 1 244 ? 11.012  -31.407 -12.078 1    27.31  ? 240 PHE A C   1 
ATOM   1972 O  O   . PHE A 1 244 ? 10.666  -31.972 -13.114 1    31.28  ? 240 PHE A O   1 
ATOM   1973 C  CB  . PHE A 1 244 ? 9.294   -29.692 -11.574 1    23.53  ? 240 PHE A CB  1 
ATOM   1974 C  CG  . PHE A 1 244 ? 8.943   -28.449 -10.781 1    28.22  ? 240 PHE A CG  1 
ATOM   1975 C  CD1 . PHE A 1 244 ? 9.93    -27.706 -10.129 1    28.7   ? 240 PHE A CD1 1 
ATOM   1976 C  CD2 . PHE A 1 244 ? 7.621   -28.03  -10.688 1    27.04  ? 240 PHE A CD2 1 
ATOM   1977 C  CE1 . PHE A 1 244 ? 9.604   -26.565 -9.411  1    28.38  ? 240 PHE A CE1 1 
ATOM   1978 C  CE2 . PHE A 1 244 ? 7.301   -26.887 -9.971  1    28.46  ? 240 PHE A CE2 1 
ATOM   1979 C  CZ  . PHE A 1 244 ? 8.292   -26.171 -9.314  1    29.09  ? 240 PHE A CZ  1 
ATOM   1980 N  N   . PRO A 1 245 ? 11.649  -32.104 -11.118 1    26.57  ? 241 PRO A N   1 
ATOM   1981 C  CA  . PRO A 1 245 ? 11.851  -33.544 -11.251 1    25.25  ? 241 PRO A CA  1 
ATOM   1982 C  C   . PRO A 1 245 ? 10.498  -34.223 -11.425 1    23.42  ? 241 PRO A C   1 
ATOM   1983 O  O   . PRO A 1 245 ? 9.5     -33.789 -10.846 1    22.46  ? 241 PRO A O   1 
ATOM   1984 C  CB  . PRO A 1 245 ? 12.563  -33.873 -9.927  1    26.2   ? 241 PRO A CB  1 
ATOM   1985 C  CG  . PRO A 1 245 ? 13.276  -32.576 -9.578  1    25.21  ? 241 PRO A CG  1 
ATOM   1986 C  CD  . PRO A 1 245 ? 12.245  -31.523 -9.905  1    23.96  ? 241 PRO A CD  1 
ATOM   1987 N  N   . LYS A 1 246 ? 10.455  -35.273 -12.252 1    27.48  ? 242 LYS A N   1 
ATOM   1988 C  CA  . LYS A 1 246 ? 9.178   -35.925 -12.561 1    33.27  ? 242 LYS A CA  1 
ATOM   1989 C  C   . LYS A 1 246 ? 9.063   -37.268 -11.84  1    29.12  ? 242 LYS A C   1 
ATOM   1990 O  O   . LYS A 1 246 ? 9.339   -38.297 -12.424 1    32.13  ? 242 LYS A O   1 
ATOM   1991 C  CB  . LYS A 1 246 ? 8.952   -36.032 -14.075 1    31.91  ? 242 LYS A CB  1 
ATOM   1992 C  CG  . LYS A 1 246 ? 8.417   -34.753 -14.692 1    44.99  ? 242 LYS A CG  1 
ATOM   1993 C  CD  . LYS A 1 246 ? 8.964   -34.539 -16.104 1    60.3   ? 242 LYS A CD  1 
ATOM   1994 C  CE  . LYS A 1 246 ? 7.908   -34.118 -17.074 1    61.35  ? 242 LYS A CE  1 
ATOM   1995 N  NZ  . LYS A 1 246 ? 8.544   -33.159 -17.97  1    70.01  ? 242 LYS A NZ  1 
ATOM   1996 N  N   . TRP A 1 247 ? 8.588   -37.235 -10.591 1    24.6   ? 243 TRP A N   1 
ATOM   1997 C  CA  . TRP A 1 247 ? 8.458   -38.423 -9.759  1    23.44  ? 243 TRP A CA  1 
ATOM   1998 C  C   . TRP A 1 247 ? 7.166   -39.151 -10.096 1    24.58  ? 243 TRP A C   1 
ATOM   1999 O  O   . TRP A 1 247 ? 6.128   -38.512 -10.267 1    25.5   ? 243 TRP A O   1 
ATOM   2000 C  CB  . TRP A 1 247 ? 8.495   -38.079 -8.259  1    21.43  ? 243 TRP A CB  1 
ATOM   2001 C  CG  . TRP A 1 247 ? 9.845   -37.651 -7.738  1    23.83  ? 243 TRP A CG  1 
ATOM   2002 C  CD1 . TRP A 1 247 ? 10.923  -38.451 -7.472  1    23.13  ? 243 TRP A CD1 1 
ATOM   2003 C  CD2 . TRP A 1 247 ? 10.255  -36.303 -7.411  1    23.03  ? 243 TRP A CD2 1 
ATOM   2004 N  NE1 . TRP A 1 247 ? 11.96   -37.702 -6.977  1    23.02  ? 243 TRP A NE1 1 
ATOM   2005 C  CE2 . TRP A 1 247 ? 11.583  -36.377 -6.942  1    25.23  ? 243 TRP A CE2 1 
ATOM   2006 C  CE3 . TRP A 1 247 ? 9.64    -35.051 -7.483  1    22.59  ? 243 TRP A CE3 1 
ATOM   2007 C  CZ2 . TRP A 1 247 ? 12.292  -35.242 -6.543  1    24.34  ? 243 TRP A CZ2 1 
ATOM   2008 C  CZ3 . TRP A 1 247 ? 10.341  -33.937 -7.083  1    24.67  ? 243 TRP A CZ3 1 
ATOM   2009 C  CH2 . TRP A 1 247 ? 11.647  -34.028 -6.611  1    23.99  ? 243 TRP A CH2 1 
ATOM   2010 N  N   . ALA A 1 248 ? 7.249   -40.478 -10.098 1    24.26  ? 244 ALA A N   1 
ATOM   2011 C  CA  . ALA A 1 248 ? 6.103   -41.344 -10.317 1    29.54  ? 244 ALA A CA  1 
ATOM   2012 C  C   . ALA A 1 248 ? 5.189   -41.334 -9.089  1    29.78  ? 244 ALA A C   1 
ATOM   2013 O  O   . ALA A 1 248 ? 5.653   -41.261 -7.949  1    32.92  ? 244 ALA A O   1 
ATOM   2014 C  CB  . ALA A 1 248 ? 6.585   -42.748 -10.699 1    23.08  ? 244 ALA A CB  1 
ATOM   2015 N  N   . ARG A 1 249 ? 3.875   -41.356 -9.336  1    32.48  ? 245 ARG A N   1 
ATOM   2016 C  CA  . ARG A 1 249 ? 2.906   -41.449 -8.252  1    37.28  ? 245 ARG A CA  1 
ATOM   2017 C  C   . ARG A 1 249 ? 3.043   -42.81  -7.581  1    39.92  ? 245 ARG A C   1 
ATOM   2018 O  O   . ARG A 1 249 ? 2.966   -43.826 -8.252  1    41.9   ? 245 ARG A O   1 
ATOM   2019 C  CB  . ARG A 1 249 ? 1.501   -41.359 -8.839  1    31.7   ? 245 ARG A CB  1 
ATOM   2020 C  CG  . ARG A 1 249 ? 0.438   -41.611 -7.788  1    32.97  ? 245 ARG A CG  1 
ATOM   2021 C  CD  . ARG A 1 249 ? -0.94   -41.231 -8.326  1    33.76  ? 245 ARG A CD  1 
ATOM   2022 N  NE  . ARG A 1 249 ? -1.902  -41.3   -7.22   1    39.63  ? 245 ARG A NE  1 
ATOM   2023 C  CZ  . ARG A 1 249 ? -2.362  -40.285 -6.492  1    38.11  ? 245 ARG A CZ  1 
ATOM   2024 N  NH1 . ARG A 1 249 ? -1.743  -39.108 -6.518  1    31.53  ? 245 ARG A NH1 1 
ATOM   2025 N  NH2 . ARG A 1 249 ? -3.443  -40.475 -5.732  1    38.46  ? 245 ARG A NH2 1 
ATOM   2026 N  N   . GLN A 1 250 ? 3.326   -42.847 -6.279  1    48.81  ? 246 GLN A N   1 
ATOM   2027 C  CA  . GLN A 1 250 ? 3.432   -44.147 -5.629  1    51.71  ? 246 GLN A CA  1 
ATOM   2028 C  C   . GLN A 1 250 ? 1.997   -44.6   -5.337  1    56.63  ? 246 GLN A C   1 
ATOM   2029 O  O   . GLN A 1 250 ? 1.117   -43.75  -5.114  1    49.49  ? 246 GLN A O   1 
ATOM   2030 C  CB  . GLN A 1 250 ? 4.371   -44.128 -4.411  1    44.8   ? 246 GLN A CB  1 
ATOM   2031 C  CG  . GLN A 1 250 ? 3.739   -43.515 -3.157  1    40.99  ? 246 GLN A CG  1 
ATOM   2032 C  CD  . GLN A 1 250 ? 4.721   -43.353 -2.016  1    50.18  ? 246 GLN A CD  1 
ATOM   2033 O  OE1 . GLN A 1 250 ? 4.883   -42.246 -1.505  1    59.91  ? 246 GLN A OE1 1 
ATOM   2034 N  NE2 . GLN A 1 250 ? 5.42    -44.413 -1.612  1    54.06  ? 246 GLN A NE2 1 
ATOM   2035 N  N   . ASP A 1 251 ? 1.792   -45.93  -5.371  1    51.32  ? 247 ASP A N   1 
ATOM   2036 C  CA  . ASP A 1 251 ? 0.547   -46.572 -4.98   1    52.68  ? 247 ASP A CA  1 
ATOM   2037 C  C   . ASP A 1 251 ? 0.095   -45.98  -3.646  1    44.55  ? 247 ASP A C   1 
ATOM   2038 O  O   . ASP A 1 251 ? 0.864   -45.925 -2.702  1    51.88  ? 247 ASP A O   1 
ATOM   2039 C  CB  . ASP A 1 251 ? 0.663   -48.095 -5.067  1    62.16  ? 247 ASP A CB  1 
ATOM   2040 C  CG  . ASP A 1 251 ? -0.603  -48.901 -4.775  1    81.49  ? 247 ASP A CG  1 
ATOM   2041 O  OD1 . ASP A 1 251 ? -1.658  -48.277 -4.502  1    92.35  ? 247 ASP A OD1 1 
ATOM   2042 O  OD2 . ASP A 1 251 ? -0.54   -50.159 -4.837  1    90.01  ? 247 ASP A OD2 1 
ATOM   2043 N  N   . PHE A 1 252 ? -1.165  -45.552 -3.565  1    40.6   ? 248 PHE A N   1 
ATOM   2044 C  CA  . PHE A 1 252 ? -1.657  -44.795 -2.431  1    34.38  ? 248 PHE A CA  1 
ATOM   2045 C  C   . PHE A 1 252 ? -1.659  -45.619 -1.14   1    33.05  ? 248 PHE A C   1 
ATOM   2046 O  O   . PHE A 1 252 ? -1.803  -45.067 -0.058  1    37.35  ? 248 PHE A O   1 
ATOM   2047 C  CB  . PHE A 1 252 ? -3.066  -44.287 -2.772  1    38.2   ? 248 PHE A CB  1 
ATOM   2048 C  CG  . PHE A 1 252 ? -3.315  -42.945 -2.1    1    37.71  ? 248 PHE A CG  1 
ATOM   2049 C  CD1 . PHE A 1 252 ? -2.782  -41.785 -2.661  1    32.37  ? 248 PHE A CD1 1 
ATOM   2050 C  CD2 . PHE A 1 252 ? -3.99   -42.845 -0.899  1    30.82  ? 248 PHE A CD2 1 
ATOM   2051 C  CE1 . PHE A 1 252 ? -2.931  -40.55  -2.07   1    27.43  ? 248 PHE A CE1 1 
ATOM   2052 C  CE2 . PHE A 1 252 ? -4.143  -41.584 -0.315  1    35.3   ? 248 PHE A CE2 1 
ATOM   2053 C  CZ  . PHE A 1 252 ? -3.609  -40.44  -0.902  1    31.37  ? 248 PHE A CZ  1 
ATOM   2054 N  N   . SER A 1 253 ? -1.607  -46.948 -1.245  1    34.73  ? 249 SER A N   1 
ATOM   2055 C  CA  . SER A 1 253 ? -1.681  -47.785 -0.059  1    36.46  ? 249 SER A CA  1 
ATOM   2056 C  C   . SER A 1 253 ? -0.37   -47.683 0.721   1    41.28  ? 249 SER A C   1 
ATOM   2057 O  O   . SER A 1 253 ? -0.278  -48.174 1.852   1    43.23  ? 249 SER A O   1 
ATOM   2058 C  CB  . SER A 1 253 ? -2      -49.237 -0.423  1    32.72  ? 249 SER A CB  1 
ATOM   2059 O  OG  . SER A 1 253 ? -0.942  -49.854 -1.15   1    35.74  ? 249 SER A OG  1 
ATOM   2060 N  N   . LYS A 1 254 ? 0.656   -47.089 0.081   1    41.89  ? 250 LYS A N   1 
ATOM   2061 C  CA  . LYS A 1 254 ? 2.001   -46.993 0.642   1    38.26  ? 250 LYS A CA  1 
ATOM   2062 C  C   . LYS A 1 254 ? 2.199   -45.645 1.332   1    36.73  ? 250 LYS A C   1 
ATOM   2063 O  O   . LYS A 1 254 ? 3.161   -45.468 2.049   1    43.7   ? 250 LYS A O   1 
ATOM   2064 C  CB  . LYS A 1 254 ? 3.035   -47.273 -0.445  1    31.03  ? 250 LYS A CB  1 
ATOM   2065 C  CG  . LYS A 1 254 ? 2.98    -48.717 -0.938  1    33.68  ? 250 LYS A CG  1 
ATOM   2066 C  CD  . LYS A 1 254 ? 3.501   -49.79  0.025   1    36.19  ? 250 LYS A CD  1 
ATOM   2067 C  CE  . LYS A 1 254 ? 3.388   -51.197 -0.519  1    36.43  ? 250 LYS A CE  1 
ATOM   2068 N  NZ  . LYS A 1 254 ? 2.003   -51.719 -0.561  1    40.25  ? 250 LYS A NZ  1 
ATOM   2069 N  N   . VAL A 1 255 ? 1.258   -44.721 1.147   1    33.56  ? 251 VAL A N   1 
ATOM   2070 C  CA  . VAL A 1 255 ? 1.343   -43.401 1.732   1    32.52  ? 251 VAL A CA  1 
ATOM   2071 C  C   . VAL A 1 255 ? 0.89    -43.444 3.18    1    34.72  ? 251 VAL A C   1 
ATOM   2072 O  O   . VAL A 1 255 ? 1.474   -42.751 4       1    40.09  ? 251 VAL A O   1 
ATOM   2073 C  CB  . VAL A 1 255 ? 0.469   -42.402 0.972   1    30.78  ? 251 VAL A CB  1 
ATOM   2074 C  CG1 . VAL A 1 255 ? 0.493   -41.051 1.666   1    29.09  ? 251 VAL A CG1 1 
ATOM   2075 C  CG2 . VAL A 1 255 ? 0.886   -42.309 -0.491  1    24.43  ? 251 VAL A CG2 1 
ATOM   2076 N  N   . VAL A 1 256 ? -0.184  -44.199 3.459   1    37.51  ? 252 VAL A N   1 
ATOM   2077 C  CA  . VAL A 1 256 ? -0.645  -44.397 4.822   1    30.33  ? 252 VAL A CA  1 
ATOM   2078 C  C   . VAL A 1 256 ? -1.051  -45.85  4.99    1    30.71  ? 252 VAL A C   1 
ATOM   2079 O  O   . VAL A 1 256 ? -2.234  -46.16  5.055   1    30.1   ? 252 VAL A O   1 
ATOM   2080 C  CB  . VAL A 1 256 ? -1.781  -43.442 5.202   1    30.73  ? 252 VAL A CB  1 
ATOM   2081 C  CG1 . VAL A 1 256 ? -2.132  -43.563 6.684   1    31.66  ? 252 VAL A CG1 1 
ATOM   2082 C  CG2 . VAL A 1 256 ? -1.41   -42.003 4.87    1    28.53  ? 252 VAL A CG2 1 
ATOM   2083 N  N   . PRO A 1 257 ? -0.062  -46.766 5.104   1    30.17  ? 253 PRO A N   1 
ATOM   2084 C  CA  . PRO A 1 257 ? -0.334  -48.208 5.102   1    27.15  ? 253 PRO A CA  1 
ATOM   2085 C  C   . PRO A 1 257 ? -1.405  -48.727 6.062   1    25.65  ? 253 PRO A C   1 
ATOM   2086 O  O   . PRO A 1 257 ? -2.093  -49.681 5.747   1    28.01  ? 253 PRO A O   1 
ATOM   2087 C  CB  . PRO A 1 257 ? 1.047   -48.839 5.401   1    29.16  ? 253 PRO A CB  1 
ATOM   2088 C  CG  . PRO A 1 257 ? 2.039   -47.779 5.003   1    28.55  ? 253 PRO A CG  1 
ATOM   2089 C  CD  . PRO A 1 257 ? 1.369   -46.438 5.248   1    25.67  ? 253 PRO A CD  1 
ATOM   2090 N  N   . PRO A 1 258 ? -1.583  -48.214 7.292   1    27.29  ? 254 PRO A N   1 
ATOM   2091 C  CA  . PRO A 1 258 ? -2.64   -48.745 8.153   1    29.95  ? 254 PRO A CA  1 
ATOM   2092 C  C   . PRO A 1 258 ? -4.062  -48.453 7.664   1    29.9   ? 254 PRO A C   1 
ATOM   2093 O  O   . PRO A 1 258 ? -4.976  -49.148 8.074   1    36.59  ? 254 PRO A O   1 
ATOM   2094 C  CB  . PRO A 1 258 ? -2.39   -48.155 9.537   1    27.16  ? 254 PRO A CB  1 
ATOM   2095 C  CG  . PRO A 1 258 ? -1.103  -47.391 9.404   1    27.64  ? 254 PRO A CG  1 
ATOM   2096 C  CD  . PRO A 1 258 ? -0.839  -47.126 7.932   1    28.26  ? 254 PRO A CD  1 
ATOM   2097 N  N   . LEU A 1 259 ? -4.231  -47.474 6.766   1    28.5   ? 255 LEU A N   1 
ATOM   2098 C  CA  . LEU A 1 259 ? -5.541  -47.058 6.261   1    26.18  ? 255 LEU A CA  1 
ATOM   2099 C  C   . LEU A 1 259 ? -6.213  -48.154 5.43    1    29.95  ? 255 LEU A C   1 
ATOM   2100 O  O   . LEU A 1 259 ? -5.596  -48.754 4.546   1    31.29  ? 255 LEU A O   1 
ATOM   2101 C  CB  . LEU A 1 259 ? -5.34   -45.81  5.415   1    23.78  ? 255 LEU A CB  1 
ATOM   2102 C  CG  . LEU A 1 259 ? -6.383  -44.72  5.608   1    27.53  ? 255 LEU A CG  1 
ATOM   2103 C  CD1 . LEU A 1 259 ? -6.821  -44.598 7.075   1    27.96  ? 255 LEU A CD1 1 
ATOM   2104 C  CD2 . LEU A 1 259 ? -5.853  -43.384 5.118   1    25.39  ? 255 LEU A CD2 1 
ATOM   2105 N  N   . ASP A 1 260 ? -7.51   -48.381 5.706   1    36.5   ? 256 ASP A N   1 
ATOM   2106 C  CA  . ASP A 1 260 ? -8.406  -49.283 4.971   1    37.15  ? 256 ASP A CA  1 
ATOM   2107 C  C   . ASP A 1 260 ? -8.739  -48.697 3.582   1    32.67  ? 256 ASP A C   1 
ATOM   2108 O  O   . ASP A 1 260 ? -8.442  -47.545 3.291   1    30.4   ? 256 ASP A O   1 
ATOM   2109 C  CB  . ASP A 1 260 ? -9.655  -49.53  5.817   1    50.44  ? 256 ASP A CB  1 
ATOM   2110 C  CG  . ASP A 1 260 ? -10.533 -48.304 6.14    1    60.94  ? 256 ASP A CG  1 
ATOM   2111 O  OD1 . ASP A 1 260 ? -11.196 -47.774 5.21    1    51.37  ? 256 ASP A OD1 1 
ATOM   2112 O  OD2 . ASP A 1 260 ? -10.57  -47.855 7.319   1    63.54  ? 256 ASP A OD2 1 
ATOM   2113 N  N   . GLU A 1 261 ? -9.444  -49.441 2.725   1    32.81  ? 257 GLU A N   1 
ATOM   2114 C  CA  . GLU A 1 261 ? -9.856  -48.934 1.417   1    34.34  ? 257 GLU A CA  1 
ATOM   2115 C  C   . GLU A 1 261 ? -10.692 -47.624 1.432   1    36.75  ? 257 GLU A C   1 
ATOM   2116 O  O   . GLU A 1 261 ? -10.467 -46.723 0.615   1    34.14  ? 257 GLU A O   1 
ATOM   2117 C  CB  . GLU A 1 261 ? -10.666 -50.025 0.742   1    35.15  ? 257 GLU A CB  1 
ATOM   2118 C  CG  . GLU A 1 261 ? -10.957 -49.657 -0.707  1    48.96  ? 257 GLU A CG  1 
ATOM   2119 C  CD  . GLU A 1 261 ? -11.628 -50.769 -1.482  1    59.58  ? 257 GLU A CD  1 
ATOM   2120 O  OE1 . GLU A 1 261 ? -11.15  -51.071 -2.604  1    67.04  ? 257 GLU A OE1 1 
ATOM   2121 O  OE2 . GLU A 1 261 ? -12.62  -51.313 -0.946  1    60.3   ? 257 GLU A OE2 1 
ATOM   2122 N  N   . ASP A 1 262 ? -11.695 -47.516 2.315   1    30.36  ? 258 ASP A N   1 
ATOM   2123 C  CA  . ASP A 1 262 ? -12.557 -46.352 2.398   1    28.09  ? 258 ASP A CA  1 
ATOM   2124 C  C   . ASP A 1 262 ? -11.729 -45.137 2.801   1    28.73  ? 258 ASP A C   1 
ATOM   2125 O  O   . ASP A 1 262 ? -11.808 -44.087 2.16    1    26.29  ? 258 ASP A O   1 
ATOM   2126 C  CB  . ASP A 1 262 ? -13.721 -46.595 3.35    1    28.89  ? 258 ASP A CB  1 
ATOM   2127 C  CG  . ASP A 1 262 ? -14.806 -47.554 2.853   1    34.69  ? 258 ASP A CG  1 
ATOM   2128 O  OD1 . ASP A 1 262 ? -14.857 -47.822 1.62    1    34.22  ? 258 ASP A OD1 1 
ATOM   2129 O  OD2 . ASP A 1 262 ? -15.582 -48.074 3.706   1    33.59  ? 258 ASP A OD2 1 
ATOM   2130 N  N   . GLY A 1 263 ? -10.932 -45.281 3.872   1    28.7   ? 259 GLY A N   1 
ATOM   2131 C  CA  . GLY A 1 263 ? -9.982  -44.245 4.275   1    26.99  ? 259 GLY A CA  1 
ATOM   2132 C  C   . GLY A 1 263 ? -9.115  -43.747 3.116   1    26.18  ? 259 GLY A C   1 
ATOM   2133 O  O   . GLY A 1 263 ? -9.02   -42.537 2.877   1    26.71  ? 259 GLY A O   1 
ATOM   2134 N  N   . ARG A 1 264 ? -8.497  -44.685 2.39    1    25.04  ? 260 ARG A N   1 
ATOM   2135 C  CA  . ARG A 1 264 ? -7.626  -44.334 1.272   1    30.71  ? 260 ARG A CA  1 
ATOM   2136 C  C   . ARG A 1 264 ? -8.419  -43.567 0.217   1    31.52  ? 260 ARG A C   1 
ATOM   2137 O  O   . ARG A 1 264 ? -7.923  -42.599 -0.374  1    31.92  ? 260 ARG A O   1 
ATOM   2138 C  CB  . ARG A 1 264 ? -6.994  -45.564 0.607   1    30.24  ? 260 ARG A CB  1 
ATOM   2139 C  CG  . ARG A 1 264 ? -5.949  -46.222 1.495   1    35.8   ? 260 ARG A CG  1 
ATOM   2140 C  CD  . ARG A 1 264 ? -4.998  -47.137 0.74    1    36.36  ? 260 ARG A CD  1 
ATOM   2141 N  NE  . ARG A 1 264 ? -5.745  -48.146 -0.011  1    37.87  ? 260 ARG A NE  1 
ATOM   2142 C  CZ  . ARG A 1 264 ? -6.205  -49.272 0.526   1    40.44  ? 260 ARG A CZ  1 
ATOM   2143 N  NH1 . ARG A 1 264 ? -5.945  -49.608 1.786   1    41.8   ? 260 ARG A NH1 1 
ATOM   2144 N  NH2 . ARG A 1 264 ? -6.932  -50.068 -0.225  1    39.79  ? 260 ARG A NH2 1 
ATOM   2145 N  N   . SER A 1 265 ? -9.644  -44.044 -0.024  1    26.81  ? 261 SER A N   1 
ATOM   2146 C  CA  . SER A 1 265 ? -10.493 -43.399 -0.994  1    27.5   ? 261 SER A CA  1 
ATOM   2147 C  C   . SER A 1 265 ? -10.678 -41.945 -0.562  1    31.51  ? 261 SER A C   1 
ATOM   2148 O  O   . SER A 1 265 ? -10.397 -41.03  -1.348  1    30.86  ? 261 SER A O   1 
ATOM   2149 C  CB  . SER A 1 265 ? -11.793 -44.155 -1.188  1    26.1   ? 261 SER A CB  1 
ATOM   2150 O  OG  . SER A 1 265 ? -12.823 -43.315 -1.705  1    29.16  ? 261 SER A OG  1 
ATOM   2151 N  N   . LEU A 1 266 ? -11.06  -41.753 0.713   1    27.95  ? 262 LEU A N   1 
ATOM   2152 C  CA  . LEU A 1 266 ? -11.416 -40.425 1.168   1    29.24  ? 262 LEU A CA  1 
ATOM   2153 C  C   . LEU A 1 266 ? -10.175 -39.544 1.079   1    33.53  ? 262 LEU A C   1 
ATOM   2154 O  O   . LEU A 1 266 ? -10.245 -38.426 0.528   1    29.88  ? 262 LEU A O   1 
ATOM   2155 C  CB  . LEU A 1 266 ? -12.043 -40.429 2.564   1    29.12  ? 262 LEU A CB  1 
ATOM   2156 C  CG  . LEU A 1 266 ? -12.263 -39.044 3.204   1    30.26  ? 262 LEU A CG  1 
ATOM   2157 C  CD1 . LEU A 1 266 ? -13.052 -38.086 2.275   1    25.03  ? 262 LEU A CD1 1 
ATOM   2158 C  CD2 . LEU A 1 266 ? -13.011 -39.201 4.527   1    27.28  ? 262 LEU A CD2 1 
ATOM   2159 N  N   . LEU A 1 267 ? -9.045  -40.085 1.588   1    33.35  ? 263 LEU A N   1 
ATOM   2160 C  CA  . LEU A 1 267 ? -7.807  -39.322 1.663   1    30.08  ? 263 LEU A CA  1 
ATOM   2161 C  C   . LEU A 1 267 ? -7.37   -38.924 0.261   1    31.06  ? 263 LEU A C   1 
ATOM   2162 O  O   . LEU A 1 267 ? -7.058  -37.759 0.033   1    34.01  ? 263 LEU A O   1 
ATOM   2163 C  CB  . LEU A 1 267 ? -6.708  -40.099 2.369   1    32.02  ? 263 LEU A CB  1 
ATOM   2164 C  CG  . LEU A 1 267 ? -5.402  -39.33  2.563   1    29.39  ? 263 LEU A CG  1 
ATOM   2165 C  CD1 . LEU A 1 267 ? -5.629  -38.198 3.547   1    32.75  ? 263 LEU A CD1 1 
ATOM   2166 C  CD2 . LEU A 1 267 ? -4.306  -40.241 3.046   1    28.79  ? 263 LEU A CD2 1 
ATOM   2167 N  N   . SER A 1 268 ? -7.368  -39.889 -0.664  1    28.42  ? 264 SER A N   1 
ATOM   2168 C  CA  . SER A 1 268 ? -7.001  -39.577 -2.04   1    33.05  ? 264 SER A CA  1 
ATOM   2169 C  C   . SER A 1 268 ? -7.822  -38.408 -2.593  1    31.16  ? 264 SER A C   1 
ATOM   2170 O  O   . SER A 1 268 ? -7.311  -37.668 -3.43   1    34.6   ? 264 SER A O   1 
ATOM   2171 C  CB  . SER A 1 268 ? -7.038  -40.779 -2.963  1    30.17  ? 264 SER A CB  1 
ATOM   2172 O  OG  . SER A 1 268 ? -8.386  -41.181 -3.151  1    44.63  ? 264 SER A OG  1 
ATOM   2173 N  N   . GLN A 1 269 ? -9.087  -38.268 -2.173  1    25.96  ? 265 GLN A N   1 
ATOM   2174 C  CA  . GLN A 1 269 ? -9.927  -37.239 -2.769  1    31.81  ? 265 GLN A CA  1 
ATOM   2175 C  C   . GLN A 1 269 ? -9.683  -35.902 -2.067  1    33.26  ? 265 GLN A C   1 
ATOM   2176 O  O   . GLN A 1 269 ? -9.955  -34.835 -2.622  1    31.18  ? 265 GLN A O   1 
ATOM   2177 C  CB  . GLN A 1 269 ? -11.402 -37.635 -2.792  1    31.07  ? 265 GLN A CB  1 
ATOM   2178 C  CG  . GLN A 1 269 ? -11.686 -38.799 -3.746  1    33.45  ? 265 GLN A CG  1 
ATOM   2179 C  CD  . GLN A 1 269 ? -13.099 -39.335 -3.607  1    38.34  ? 265 GLN A CD  1 
ATOM   2180 O  OE1 . GLN A 1 269 ? -13.338 -40.427 -3.073  1    38.4   ? 265 GLN A OE1 1 
ATOM   2181 N  NE2 . GLN A 1 269 ? -14.074 -38.537 -4.019  1    39.45  ? 265 GLN A NE2 1 
ATOM   2182 N  N   . MET A 1 270 ? -9.166  -35.966 -0.834  1    30.33  ? 266 MET A N   1 
ATOM   2183 C  CA  . MET A 1 270 ? -8.832  -34.739 -0.147  1    31.31  ? 266 MET A CA  1 
ATOM   2184 C  C   . MET A 1 270 ? -7.526  -34.15  -0.697  1    36.97  ? 266 MET A C   1 
ATOM   2185 O  O   . MET A 1 270 ? -7.361  -32.925 -0.684  1    39.33  ? 266 MET A O   1 
ATOM   2186 C  CB  . MET A 1 270 ? -8.785  -34.95  1.359   1    27.14  ? 266 MET A CB  1 
ATOM   2187 C  CG  . MET A 1 270 ? -10.137 -35.279 1.896   1    30.09  ? 266 MET A CG  1 
ATOM   2188 S  SD  . MET A 1 270 ? -10.187 -35.672 3.664   1    34.15  ? 266 MET A SD  1 
ATOM   2189 C  CE  . MET A 1 270 ? -10.246 -33.995 4.314   1    24.59  ? 266 MET A CE  1 
ATOM   2190 N  N   . LEU A 1 271 ? -6.655  -35.004 -1.261  1    32.75  ? 267 LEU A N   1 
ATOM   2191 C  CA  . LEU A 1 271 ? -5.316  -34.621 -1.682  1    33.64  ? 267 LEU A CA  1 
ATOM   2192 C  C   . LEU A 1 271 ? -5.197  -34.645 -3.202  1    36.78  ? 267 LEU A C   1 
ATOM   2193 O  O   . LEU A 1 271 ? -4.104  -34.803 -3.757  1    34.79  ? 267 LEU A O   1 
ATOM   2194 C  CB  . LEU A 1 271 ? -4.291  -35.57  -1.052  1    31.74  ? 267 LEU A CB  1 
ATOM   2195 C  CG  . LEU A 1 271 ? -4.24   -35.627 0.473   1    31.78  ? 267 LEU A CG  1 
ATOM   2196 C  CD1 . LEU A 1 271 ? -3.231  -36.655 0.914   1    30.91  ? 267 LEU A CD1 1 
ATOM   2197 C  CD2 . LEU A 1 271 ? -3.895  -34.263 1.036   1    32.56  ? 267 LEU A CD2 1 
ATOM   2198 N  N   . HIS A 1 272 ? -6.325  -34.492 -3.886  1    33.52  ? 268 HIS A N   1 
ATOM   2199 C  CA  . HIS A 1 272 ? -6.268  -34.423 -5.337  1    37.16  ? 268 HIS A CA  1 
ATOM   2200 C  C   . HIS A 1 272 ? -5.534  -33.136 -5.72   1    38.43  ? 268 HIS A C   1 
ATOM   2201 O  O   . HIS A 1 272 ? -5.794  -32.081 -5.124  1    36.04  ? 268 HIS A O   1 
ATOM   2202 C  CB  . HIS A 1 272 ? -7.705  -34.425 -5.875  1    38.36  ? 268 HIS A CB  1 
ATOM   2203 C  CG  . HIS A 1 272 ? -7.903  -35.002 -7.224  1    50.48  ? 268 HIS A CG  1 
ATOM   2204 N  ND1 . HIS A 1 272 ? -7.544  -34.344 -8.393  1    67.98  ? 268 HIS A ND1 1 
ATOM   2205 C  CD2 . HIS A 1 272 ? -8.435  -36.185 -7.573  1    50.47  ? 268 HIS A CD2 1 
ATOM   2206 C  CE1 . HIS A 1 272 ? -7.831  -35.106 -9.436  1    62.98  ? 268 HIS A CE1 1 
ATOM   2207 N  NE2 . HIS A 1 272 ? -8.389  -36.221 -8.957  1    74.76  ? 268 HIS A NE2 1 
ATOM   2208 N  N   . TYR A 1 273 ? -4.664  -33.221 -6.737  1    35.27  ? 269 TYR A N   1 
ATOM   2209 C  CA  . TYR A 1 273 ? -3.918  -32.065 -7.219  1    35.47  ? 269 TYR A CA  1 
ATOM   2210 C  C   . TYR A 1 273 ? -4.866  -30.952 -7.655  1    34.41  ? 269 TYR A C   1 
ATOM   2211 O  O   . TYR A 1 273 ? -4.794  -29.811 -7.183  1    40.57  ? 269 TYR A O   1 
ATOM   2212 C  CB  . TYR A 1 273 ? -2.902  -32.387 -8.32   1    29.25  ? 269 TYR A CB  1 
ATOM   2213 C  CG  . TYR A 1 273 ? -1.581  -32.871 -7.77   1    32.23  ? 269 TYR A CG  1 
ATOM   2214 C  CD1 . TYR A 1 273 ? -0.74   -32.012 -7.064  1    34.88  ? 269 TYR A CD1 1 
ATOM   2215 C  CD2 . TYR A 1 273 ? -1.186  -34.193 -7.917  1    32.68  ? 269 TYR A CD2 1 
ATOM   2216 C  CE1 . TYR A 1 273 ? 0.479   -32.448 -6.573  1    32.84  ? 269 TYR A CE1 1 
ATOM   2217 C  CE2 . TYR A 1 273 ? 0.028   -34.641 -7.415  1    30.5   ? 269 TYR A CE2 1 
ATOM   2218 C  CZ  . TYR A 1 273 ? 0.869   -33.768 -6.747  1    33.51  ? 269 TYR A CZ  1 
ATOM   2219 O  OH  . TYR A 1 273 ? 2.062   -34.229 -6.235  1    33.11  ? 269 TYR A OH  1 
ATOM   2220 N  N   . ASP A 1 274 ? -5.748  -31.3   -8.584  1    32.82  ? 270 ASP A N   1 
ATOM   2221 C  CA  . ASP A 1 274 ? -6.609  -30.311 -9.213  1    31.33  ? 270 ASP A CA  1 
ATOM   2222 C  C   . ASP A 1 274 ? -7.617  -29.799 -8.185  1    36.41  ? 270 ASP A C   1 
ATOM   2223 O  O   . ASP A 1 274 ? -8.388  -30.583 -7.635  1    40.07  ? 270 ASP A O   1 
ATOM   2224 C  CB  . ASP A 1 274 ? -7.299  -30.976 -10.386 1    28.53  ? 270 ASP A CB  1 
ATOM   2225 C  CG  . ASP A 1 274 ? -8.108  -30.038 -11.245 1    30.33  ? 270 ASP A CG  1 
ATOM   2226 O  OD1 . ASP A 1 274 ? -8.358  -28.893 -10.789 1    30.48  ? 270 ASP A OD1 1 
ATOM   2227 O  OD2 . ASP A 1 274 ? -8.47   -30.477 -12.367 1    38.53  ? 270 ASP A OD2 1 
ATOM   2228 N  N   . PRO A 1 275 ? -7.661  -28.494 -7.842  1    39.73  ? 271 PRO A N   1 
ATOM   2229 C  CA  . PRO A 1 275 ? -8.592  -28.036 -6.81   1    36.71  ? 271 PRO A CA  1 
ATOM   2230 C  C   . PRO A 1 275 ? -10.045 -28.223 -7.238  1    38.85  ? 271 PRO A C   1 
ATOM   2231 O  O   . PRO A 1 275 ? -10.948 -28.299 -6.381  1    37.16  ? 271 PRO A O   1 
ATOM   2232 C  CB  . PRO A 1 275 ? -8.201  -26.55  -6.579  1    33.85  ? 271 PRO A CB  1 
ATOM   2233 C  CG  . PRO A 1 275 ? -6.804  -26.431 -7.134  1    32.47  ? 271 PRO A CG  1 
ATOM   2234 C  CD  . PRO A 1 275 ? -6.776  -27.419 -8.315  1    37.87  ? 271 PRO A CD  1 
ATOM   2235 N  N   . ASN A 1 276 ? -10.26  -28.306 -8.563  1    34.38  ? 272 ASN A N   1 
ATOM   2236 C  CA  . ASN A 1 276 ? -11.601 -28.548 -9.084  1    37.47  ? 272 ASN A CA  1 
ATOM   2237 C  C   . ASN A 1 276 ? -12.069 -29.974 -8.794  1    35.34  ? 272 ASN A C   1 
ATOM   2238 O  O   . ASN A 1 276 ? -13.254 -30.174 -8.633  1    34.99  ? 272 ASN A O   1 
ATOM   2239 C  CB  . ASN A 1 276 ? -11.754 -28.223 -10.567 1    33.92  ? 272 ASN A CB  1 
ATOM   2240 C  CG  . ASN A 1 276 ? -11.402 -26.788 -10.853 1    39.21  ? 272 ASN A CG  1 
ATOM   2241 O  OD1 . ASN A 1 276 ? -11.756 -25.888 -10.083 1    45.86  ? 272 ASN A OD1 1 
ATOM   2242 N  ND2 . ASN A 1 276 ? -10.655 -26.556 -11.915 1    43.3   ? 272 ASN A ND2 1 
ATOM   2243 N  N   . LYS A 1 277 ? -11.168 -30.961 -8.764  1    34.82  ? 273 LYS A N   1 
ATOM   2244 C  CA  . LYS A 1 277 ? -11.566 -32.346 -8.557  1    37.33  ? 273 LYS A CA  1 
ATOM   2245 C  C   . LYS A 1 277 ? -11.574 -32.657 -7.061  1    33.46  ? 273 LYS A C   1 
ATOM   2246 O  O   . LYS A 1 277 ? -12.129 -33.657 -6.627  1    31.41  ? 273 LYS A O   1 
ATOM   2247 C  CB  . LYS A 1 277 ? -10.651 -33.321 -9.31   1    39.23  ? 273 LYS A CB  1 
ATOM   2248 C  CG  . LYS A 1 277 ? -10.5   -33.122 -10.811 1    53.6   ? 273 LYS A CG  1 
ATOM   2249 C  CD  . LYS A 1 277 ? -11.773 -33.351 -11.614 1    69.01  ? 273 LYS A CD  1 
ATOM   2250 C  CE  . LYS A 1 277 ? -11.91  -32.479 -12.827 1    82.77  ? 273 LYS A CE  1 
ATOM   2251 N  NZ  . LYS A 1 277 ? -13.283 -32.026 -13.075 1    81.62  ? 273 LYS A NZ  1 
ATOM   2252 N  N   . ARG A 1 278 ? -10.903 -31.819 -6.265  1    31.63  ? 274 ARG A N   1 
ATOM   2253 C  CA  . ARG A 1 278 ? -10.706 -32.153 -4.863  1    30.01  ? 274 ARG A CA  1 
ATOM   2254 C  C   . ARG A 1 278 ? -12.072 -32.156 -4.174  1    30.93  ? 274 ARG A C   1 
ATOM   2255 O  O   . ARG A 1 278 ? -12.908 -31.283 -4.433  1    29.34  ? 274 ARG A O   1 
ATOM   2256 C  CB  . ARG A 1 278 ? -9.771  -31.107 -4.257  1    30.45  ? 274 ARG A CB  1 
ATOM   2257 C  CG  . ARG A 1 278 ? -9.106  -31.531 -2.955  1    32.87  ? 274 ARG A CG  1 
ATOM   2258 C  CD  . ARG A 1 278 ? -8.112  -30.462 -2.481  1    33.25  ? 274 ARG A CD  1 
ATOM   2259 N  NE  . ARG A 1 278 ? -7.012  -30.224 -3.429  1    32.48  ? 274 ARG A NE  1 
ATOM   2260 C  CZ  . ARG A 1 278 ? -6.317  -29.101 -3.49   1    29.44  ? 274 ARG A CZ  1 
ATOM   2261 N  NH1 . ARG A 1 278 ? -6.535  -28.125 -2.629  1    26.97  ? 274 ARG A NH1 1 
ATOM   2262 N  NH2 . ARG A 1 278 ? -5.424  -28.953 -4.439  1    30.62  ? 274 ARG A NH2 1 
ATOM   2263 N  N   . ILE A 1 279 ? -12.303 -33.142 -3.309  1    25.31  ? 275 ILE A N   1 
ATOM   2264 C  CA  . ILE A 1 279 ? -13.612 -33.272 -2.694  1    27.68  ? 275 ILE A CA  1 
ATOM   2265 C  C   . ILE A 1 279 ? -13.932 -32.046 -1.824  1    29.67  ? 275 ILE A C   1 
ATOM   2266 O  O   . ILE A 1 279 ? -13.037 -31.499 -1.199  1    34.71  ? 275 ILE A O   1 
ATOM   2267 C  CB  . ILE A 1 279 ? -13.661 -34.594 -1.919  1    27.34  ? 275 ILE A CB  1 
ATOM   2268 C  CG1 . ILE A 1 279 ? -15.101 -34.954 -1.546  1    24.5   ? 275 ILE A CG1 1 
ATOM   2269 C  CG2 . ILE A 1 279 ? -12.713 -34.55  -0.714  1    26.38  ? 275 ILE A CG2 1 
ATOM   2270 C  CD1 . ILE A 1 279 ? -15.282 -36.385 -1.098  1    23.39  ? 275 ILE A CD1 1 
ATOM   2271 N  N   . SER A 1 280 ? -15.203 -31.615 -1.765  1    28.45  ? 276 SER A N   1 
ATOM   2272 C  CA  . SER A 1 280 ? -15.631 -30.599 -0.794  1    32.78  ? 276 SER A CA  1 
ATOM   2273 C  C   . SER A 1 280 ? -15.939 -31.216 0.576   1    34     ? 276 SER A C   1 
ATOM   2274 O  O   . SER A 1 280 ? -16.272 -32.405 0.66    1    28.27  ? 276 SER A O   1 
ATOM   2275 C  CB  . SER A 1 280 ? -16.873 -29.877 -1.292  1    34.38  ? 276 SER A CB  1 
ATOM   2276 O  OG  . SER A 1 280 ? -17.929 -30.809 -1.43   1    34.12  ? 276 SER A OG  1 
ATOM   2277 N  N   . ALA A 1 281 ? -15.927 -30.386 1.64    1    38.09  ? 277 ALA A N   1 
ATOM   2278 C  CA  . ALA A 1 281 ? -16.347 -30.835 2.976   1    37.06  ? 277 ALA A CA  1 
ATOM   2279 C  C   . ALA A 1 281 ? -17.777 -31.368 2.956   1    35.78  ? 277 ALA A C   1 
ATOM   2280 O  O   . ALA A 1 281 ? -18.094 -32.385 3.577   1    39.27  ? 277 ALA A O   1 
ATOM   2281 C  CB  . ALA A 1 281 ? -16.239 -29.734 4.004   1    34.42  ? 277 ALA A CB  1 
ATOM   2282 N  N   . LYS A 1 282 ? -18.643 -30.683 2.215   1    35.71  ? 278 LYS A N   1 
ATOM   2283 C  CA  . LYS A 1 282 ? -20.045 -31.074 2.123   1    36.25  ? 278 LYS A CA  1 
ATOM   2284 C  C   . LYS A 1 282 ? -20.189 -32.481 1.528   1    33.26  ? 278 LYS A C   1 
ATOM   2285 O  O   . LYS A 1 282 ? -20.884 -33.316 2.1     1    30.96  ? 278 LYS A O   1 
ATOM   2286 C  CB  . LYS A 1 282 ? -20.763 -29.908 1.432   1    33.5   ? 278 LYS A CB  1 
ATOM   2287 C  CG  . LYS A 1 282 ? -22.204 -30.045 1.065   1    35.38  ? 278 LYS A CG  1 
ATOM   2288 C  CD  . LYS A 1 282 ? -22.655 -28.78  0.322   1    39.6   ? 278 LYS A CD  1 
ATOM   2289 C  CE  . LYS A 1 282 ? -23.114 -27.662 1.201   1    39.08  ? 278 LYS A CE  1 
ATOM   2290 N  NZ  . LYS A 1 282 ? -23.944 -26.672 0.506   1    32.35  ? 278 LYS A NZ  1 
ATOM   2291 N  N   . ALA A 1 283 ? -19.497 -32.777 0.419   1    37.07  ? 279 ALA A N   1 
ATOM   2292 C  CA  . ALA A 1 283 ? -19.588 -34.105 -0.221  1    35.86  ? 279 ALA A CA  1 
ATOM   2293 C  C   . ALA A 1 283 ? -18.91  -35.204 0.614   1    31.26  ? 279 ALA A C   1 
ATOM   2294 O  O   . ALA A 1 283 ? -19.37  -36.343 0.619   1    35.66  ? 279 ALA A O   1 
ATOM   2295 C  CB  . ALA A 1 283 ? -19.044 -34.07  -1.641  1    23.68  ? 279 ALA A CB  1 
ATOM   2296 N  N   . ALA A 1 284 ? -17.852 -34.832 1.348   1    26.64  ? 280 ALA A N   1 
ATOM   2297 C  CA  . ALA A 1 284 ? -17.044 -35.748 2.135   1    26.79  ? 280 ALA A CA  1 
ATOM   2298 C  C   . ALA A 1 284 ? -17.843 -36.344 3.289   1    30     ? 280 ALA A C   1 
ATOM   2299 O  O   . ALA A 1 284 ? -17.532 -37.457 3.705   1    33.39  ? 280 ALA A O   1 
ATOM   2300 C  CB  . ALA A 1 284 ? -15.781 -35.084 2.618   1    21.91  ? 280 ALA A CB  1 
ATOM   2301 N  N   . LEU A 1 285 ? -18.877 -35.632 3.773   1    28.88  ? 281 LEU A N   1 
ATOM   2302 C  CA  . LEU A 1 285 ? -19.654 -36.08  4.921   1    27.94  ? 281 LEU A CA  1 
ATOM   2303 C  C   . LEU A 1 285 ? -20.403 -37.355 4.591   1    31.97  ? 281 LEU A C   1 
ATOM   2304 O  O   . LEU A 1 285 ? -20.848 -38.042 5.514   1    33.53  ? 281 LEU A O   1 
ATOM   2305 C  CB  . LEU A 1 285 ? -20.654 -35.013 5.345   1    29.09  ? 281 LEU A CB  1 
ATOM   2306 C  CG  . LEU A 1 285 ? -20.043 -33.741 5.935   1    28.97  ? 281 LEU A CG  1 
ATOM   2307 C  CD1 . LEU A 1 285 ? -21.149 -32.717 6.118   1    25.35  ? 281 LEU A CD1 1 
ATOM   2308 C  CD2 . LEU A 1 285 ? -19.381 -34.099 7.232   1    27.78  ? 281 LEU A CD2 1 
ATOM   2309 N  N   . ALA A 1 286 ? -20.578 -37.619 3.283   1    29.66  ? 282 ALA A N   1 
ATOM   2310 C  CA  . ALA A 1 286 ? -21.345 -38.771 2.834   1    28.22  ? 282 ALA A CA  1 
ATOM   2311 C  C   . ALA A 1 286 ? -20.439 -39.931 2.435   1    27.82  ? 282 ALA A C   1 
ATOM   2312 O  O   . ALA A 1 286 ? -20.921 -40.981 2.022   1    29.94  ? 282 ALA A O   1 
ATOM   2313 C  CB  . ALA A 1 286 ? -22.213 -38.371 1.673   1    32.15  ? 282 ALA A CB  1 
ATOM   2314 N  N   . HIS A 1 287 ? -19.125 -39.743 2.552   1    29.62  ? 283 HIS A N   1 
ATOM   2315 C  CA  . HIS A 1 287 ? -18.197 -40.766 2.115   1    28     ? 283 HIS A CA  1 
ATOM   2316 C  C   . HIS A 1 287 ? -18.37  -42.014 2.977   1    26.21  ? 283 HIS A C   1 
ATOM   2317 O  O   . HIS A 1 287 ? -18.52  -41.959 4.19    1    27.77  ? 283 HIS A O   1 
ATOM   2318 C  CB  . HIS A 1 287 ? -16.771 -40.231 2.143   1    26.65  ? 283 HIS A CB  1 
ATOM   2319 C  CG  . HIS A 1 287 ? -15.797 -41.157 1.501   1    31.39  ? 283 HIS A CG  1 
ATOM   2320 N  ND1 . HIS A 1 287 ? -15.436 -42.37  2.058   1    30.03  ? 283 HIS A ND1 1 
ATOM   2321 C  CD2 . HIS A 1 287 ? -15.104 -41.043 0.331   1    28.22  ? 283 HIS A CD2 1 
ATOM   2322 C  CE1 . HIS A 1 287 ? -14.574 -42.971 1.229   1    34.35  ? 283 HIS A CE1 1 
ATOM   2323 N  NE2 . HIS A 1 287 ? -14.369 -42.194 0.164   1    27.63  ? 283 HIS A NE2 1 
ATOM   2324 N  N   . PRO A 1 288 ? -18.364 -43.198 2.36    1    25.78  ? 284 PRO A N   1 
ATOM   2325 C  CA  . PRO A 1 288 ? -18.5   -44.448 3.114   1    24.77  ? 284 PRO A CA  1 
ATOM   2326 C  C   . PRO A 1 288 ? -17.537 -44.658 4.29    1    26.01  ? 284 PRO A C   1 
ATOM   2327 O  O   . PRO A 1 288 ? -17.825 -45.473 5.179   1    27.31  ? 284 PRO A O   1 
ATOM   2328 C  CB  . PRO A 1 288 ? -18.347 -45.566 2.073   1    22.41  ? 284 PRO A CB  1 
ATOM   2329 C  CG  . PRO A 1 288 ? -18.205 -44.874 0.722   1    22.52  ? 284 PRO A CG  1 
ATOM   2330 C  CD  . PRO A 1 288 ? -18.181 -43.371 0.91    1    22.36  ? 284 PRO A CD  1 
ATOM   2331 N  N   . PHE A 1 289 ? -16.405 -43.927 4.313   1    24.5   ? 285 PHE A N   1 
ATOM   2332 C  CA  . PHE A 1 289 ? -15.488 -44.017 5.439   1    23.44  ? 285 PHE A CA  1 
ATOM   2333 C  C   . PHE A 1 289 ? -16.207 -43.701 6.76    1    26.52  ? 285 PHE A C   1 
ATOM   2334 O  O   . PHE A 1 289 ? -15.84  -44.23  7.816   1    28.39  ? 285 PHE A O   1 
ATOM   2335 C  CB  . PHE A 1 289 ? -14.306 -43.075 5.231   1    25.3   ? 285 PHE A CB  1 
ATOM   2336 C  CG  . PHE A 1 289 ? -13.284 -43.087 6.353   1    29.87  ? 285 PHE A CG  1 
ATOM   2337 C  CD1 . PHE A 1 289 ? -12.429 -44.178 6.539   1    30.93  ? 285 PHE A CD1 1 
ATOM   2338 C  CD2 . PHE A 1 289 ? -13.196 -42.023 7.247   1    32.2   ? 285 PHE A CD2 1 
ATOM   2339 C  CE1 . PHE A 1 289 ? -11.506 -44.196 7.578   1    29.12  ? 285 PHE A CE1 1 
ATOM   2340 C  CE2 . PHE A 1 289 ? -12.266 -42.045 8.288   1    29.29  ? 285 PHE A CE2 1 
ATOM   2341 C  CZ  . PHE A 1 289 ? -11.417 -43.126 8.442   1    27.87  ? 285 PHE A CZ  1 
ATOM   2342 N  N   . PHE A 1 290 ? -17.246 -42.856 6.712   1    22.65  ? 286 PHE A N   1 
ATOM   2343 C  CA  . PHE A 1 290 ? -17.954 -42.471 7.916   1    24.31  ? 286 PHE A CA  1 
ATOM   2344 C  C   . PHE A 1 290 ? -19.158 -43.373 8.228   1    28.63  ? 286 PHE A C   1 
ATOM   2345 O  O   . PHE A 1 290 ? -19.873 -43.108 9.206   1    26.96  ? 286 PHE A O   1 
ATOM   2346 C  CB  . PHE A 1 290 ? -18.395 -41.01  7.812   1    22.42  ? 286 PHE A CB  1 
ATOM   2347 C  CG  . PHE A 1 290 ? -17.225 -40.06  7.641   1    23.18  ? 286 PHE A CG  1 
ATOM   2348 C  CD1 . PHE A 1 290 ? -16.252 -39.962 8.63    1    24.42  ? 286 PHE A CD1 1 
ATOM   2349 C  CD2 . PHE A 1 290 ? -17.083 -39.297 6.492   1    23.74  ? 286 PHE A CD2 1 
ATOM   2350 C  CE1 . PHE A 1 290 ? -15.196 -39.098 8.467   1    25.17  ? 286 PHE A CE1 1 
ATOM   2351 C  CE2 . PHE A 1 290 ? -16.004 -38.443 6.333   1    25.15  ? 286 PHE A CE2 1 
ATOM   2352 C  CZ  . PHE A 1 290 ? -15.062 -38.331 7.323   1    25.32  ? 286 PHE A CZ  1 
ATOM   2353 N  N   . GLN A 1 291 ? -19.364 -44.442 7.448   1    28.48  ? 287 GLN A N   1 
ATOM   2354 C  CA  . GLN A 1 291 ? -20.581 -45.229 7.546   1    34.07  ? 287 GLN A CA  1 
ATOM   2355 C  C   . GLN A 1 291 ? -20.946 -45.594 8.988   1    41.56  ? 287 GLN A C   1 
ATOM   2356 O  O   . GLN A 1 291 ? -22.137 -45.659 9.328   1    58.85  ? 287 GLN A O   1 
ATOM   2357 C  CB  . GLN A 1 291 ? -20.598 -46.432 6.607   1    34.42  ? 287 GLN A CB  1 
ATOM   2358 C  CG  . GLN A 1 291 ? -19.797 -47.626 7.107   1    47.97  ? 287 GLN A CG  1 
ATOM   2359 C  CD  . GLN A 1 291 ? -19.745 -48.791 6.13    1    65.75  ? 287 GLN A CD  1 
ATOM   2360 O  OE1 . GLN A 1 291 ? -20.336 -49.86  6.367   1    69.33  ? 287 GLN A OE1 1 
ATOM   2361 N  NE2 . GLN A 1 291 ? -19.046 -48.592 5.013   1    51.66  ? 287 GLN A NE2 1 
ATOM   2362 N  N   . ASP A 1 292 ? -19.95  -45.837 9.849   1    38.51  ? 288 ASP A N   1 
ATOM   2363 C  CA  . ASP A 1 292 ? -20.249 -46.477 11.132  1    46.11  ? 288 ASP A CA  1 
ATOM   2364 C  C   . ASP A 1 292 ? -19.955 -45.52  12.293  1    39.92  ? 288 ASP A C   1 
ATOM   2365 O  O   . ASP A 1 292 ? -19.804 -45.954 13.429  1    33.34  ? 288 ASP A O   1 
ATOM   2366 C  CB  . ASP A 1 292 ? -19.532 -47.823 11.235  1    52.98  ? 288 ASP A CB  1 
ATOM   2367 C  CG  . ASP A 1 292 ? -18.037 -47.775 10.894  1    73.63  ? 288 ASP A CG  1 
ATOM   2368 O  OD1 . ASP A 1 292 ? -17.521 -46.682 10.414  1    60.88  ? 288 ASP A OD1 1 
ATOM   2369 O  OD2 . ASP A 1 292 ? -17.382 -48.831 11.093  1    68.62  ? 288 ASP A OD2 1 
ATOM   2370 N  N   . VAL A 1 293 ? -19.937 -44.21  12.001  1    36.72  ? 289 VAL A N   1 
ATOM   2371 C  CA  . VAL A 1 293 ? -19.325 -43.217 12.863  1    38.97  ? 289 VAL A CA  1 
ATOM   2372 C  C   . VAL A 1 293 ? -20.186 -42.943 14.099  1    46.21  ? 289 VAL A C   1 
ATOM   2373 O  O   . VAL A 1 293 ? -21.411 -43.096 14.067  1    42.37  ? 289 VAL A O   1 
ATOM   2374 C  CB  . VAL A 1 293 ? -19.025 -41.95  12.05   1    38.85  ? 289 VAL A CB  1 
ATOM   2375 C  CG1 . VAL A 1 293 ? -20.295 -41.217 11.698  1    45.56  ? 289 VAL A CG1 1 
ATOM   2376 C  CG2 . VAL A 1 293 ? -18.076 -41.013 12.764  1    40     ? 289 VAL A CG2 1 
ATOM   2377 N  N   . THR A 1 294 ? -19.489 -42.571 15.188  1    52.8   ? 290 THR A N   1 
ATOM   2378 C  CA  . THR A 1 294 ? -20.028 -42.202 16.498  1    61.18  ? 290 THR A CA  1 
ATOM   2379 C  C   . THR A 1 294 ? -19.236 -41.01  17.051  1    61.56  ? 290 THR A C   1 
ATOM   2380 O  O   . THR A 1 294 ? -18.388 -40.457 16.351  1    65.76  ? 290 THR A O   1 
ATOM   2381 C  CB  . THR A 1 294 ? -19.996 -43.391 17.461  1    65.12  ? 290 THR A CB  1 
ATOM   2382 O  OG1 . THR A 1 294 ? -18.684 -43.959 17.376  1    52.69  ? 290 THR A OG1 1 
ATOM   2383 C  CG2 . THR A 1 294 ? -21.133 -44.383 17.226  1    67.18  ? 290 THR A CG2 1 
ATOM   2384 N  N   . LYS A 1 295 ? -19.511 -40.602 18.301  1    56.97  ? 291 LYS A N   1 
ATOM   2385 C  CA  . LYS A 1 295 ? -18.762 -39.539 18.965  1    59.75  ? 291 LYS A CA  1 
ATOM   2386 C  C   . LYS A 1 295 ? -18.221 -40.009 20.328  1    67.74  ? 291 LYS A C   1 
ATOM   2387 O  O   . LYS A 1 295 ? -18.709 -39.551 21.375  1    64.35  ? 291 LYS A O   1 
ATOM   2388 C  CB  . LYS A 1 295 ? -19.644 -38.287 19.057  1    60.49  ? 291 LYS A CB  1 
ATOM   2389 C  CG  . LYS A 1 295 ? -19.128 -37.115 19.908  1    64.21  ? 291 LYS A CG  1 
ATOM   2390 C  CD  . LYS A 1 295 ? -19.585 -35.765 19.349  1    81.51  ? 291 LYS A CD  1 
ATOM   2391 C  CE  . LYS A 1 295 ? -19.467 -34.551 20.246  1    91.38  ? 291 LYS A CE  1 
ATOM   2392 N  NZ  . LYS A 1 295 ? -19.726 -33.292 19.518  1    71.25  ? 291 LYS A NZ  1 
ATOM   2393 N  N   . PRO A 1 296 ? -17.182 -40.897 20.378  1    59.52  ? 292 PRO A N   1 
ATOM   2394 C  CA  . PRO A 1 296 ? -16.588 -41.315 21.651  1    57.43  ? 292 PRO A CA  1 
ATOM   2395 C  C   . PRO A 1 296 ? -15.677 -40.212 22.203  1    51.85  ? 292 PRO A C   1 
ATOM   2396 O  O   . PRO A 1 296 ? -15.312 -39.301 21.468  1    44.15  ? 292 PRO A O   1 
ATOM   2397 C  CB  . PRO A 1 296 ? -15.848 -42.621 21.252  1    50.19  ? 292 PRO A CB  1 
ATOM   2398 C  CG  . PRO A 1 296 ? -15.397 -42.378 19.836  1    44.12  ? 292 PRO A CG  1 
ATOM   2399 C  CD  . PRO A 1 296 ? -16.508 -41.536 19.23   1    51.86  ? 292 PRO A CD  1 
ATOM   2400 N  N   . VAL A 1 297 ? -15.332 -40.299 23.499  1    57.31  ? 293 VAL A N   1 
ATOM   2401 C  CA  . VAL A 1 297 ? -14.662 -39.241 24.256  1    53.6   ? 293 VAL A CA  1 
ATOM   2402 C  C   . VAL A 1 297 ? -13.155 -39.375 24.077  1    50.06  ? 293 VAL A C   1 
ATOM   2403 O  O   . VAL A 1 297 ? -12.713 -40.448 23.682  1    51.72  ? 293 VAL A O   1 
ATOM   2404 C  CB  . VAL A 1 297 ? -15.03  -39.28  25.754  1    46.62  ? 293 VAL A CB  1 
ATOM   2405 C  CG1 . VAL A 1 297 ? -16.507 -39     25.989  1    50.39  ? 293 VAL A CG1 1 
ATOM   2406 C  CG2 . VAL A 1 297 ? -14.607 -40.565 26.446  1    36.93  ? 293 VAL A CG2 1 
ATOM   2407 N  N   . PRO A 1 298 ? -12.333 -38.327 24.341  1    55     ? 294 PRO A N   1 
ATOM   2408 C  CA  . PRO A 1 298 ? -10.878 -38.472 24.366  1    59.26  ? 294 PRO A CA  1 
ATOM   2409 C  C   . PRO A 1 298 ? -10.567 -39.577 25.391  1    70.44  ? 294 PRO A C   1 
ATOM   2410 O  O   . PRO A 1 298 ? -11.141 -39.593 26.503  1    54.24  ? 294 PRO A O   1 
ATOM   2411 C  CB  . PRO A 1 298 ? -10.382 -37.054 24.814  1    46.31  ? 294 PRO A CB  1 
ATOM   2412 C  CG  . PRO A 1 298 ? -11.541 -36.479 25.537  1    49.22  ? 294 PRO A CG  1 
ATOM   2413 C  CD  . PRO A 1 298 ? -12.73  -36.95  24.673  1    57.28  ? 294 PRO A CD  1 
ATOM   2414 N  N   . GLY B 2 1   ? -14.557 -25.064 -11.648 1    28.47  ? 171 GLY B N   1 
ATOM   2415 C  CA  . GLY B 2 1   ? -15.237 -23.871 -11.166 1    33.26  ? 171 GLY B CA  1 
ATOM   2416 C  C   . GLY B 2 1   ? -15.105 -23.764 -9.636  1    40.48  ? 171 GLY B C   1 
ATOM   2417 O  O   . GLY B 2 1   ? -15.854 -22.993 -9.041  1    45.74  ? 171 GLY B O   1 
ATOM   2418 N  N   . VAL B 2 2   ? -14.169 -24.487 -8.988  1    33.28  ? 172 VAL B N   1 
ATOM   2419 C  CA  . VAL B 2 2   ? -14.013 -24.349 -7.548  1    36.03  ? 172 VAL B CA  1 
ATOM   2420 C  C   . VAL B 2 2   ? -13.822 -22.875 -7.124  1    36.42  ? 172 VAL B C   1 
ATOM   2421 O  O   . VAL B 2 2   ? -14.225 -22.485 -6.019  1    34.38  ? 172 VAL B O   1 
ATOM   2422 C  CB  . VAL B 2 2   ? -12.933 -25.255 -6.938  1    35.75  ? 172 VAL B CB  1 
ATOM   2423 C  CG1 . VAL B 2 2   ? -11.551 -24.657 -7.14   1    32.48  ? 172 VAL B CG1 1 
ATOM   2424 C  CG2 . VAL B 2 2   ? -13.186 -25.445 -5.44   1    32.79  ? 172 VAL B CG2 1 
ATOM   2425 N  N   . ASN B 2 3   ? -13.26  -22.052 -8.018  1    34.82  ? 173 ASN B N   1 
ATOM   2426 C  CA  . ASN B 2 3   ? -13.133 -20.616 -7.785  1    37.64  ? 173 ASN B CA  1 
ATOM   2427 C  C   . ASN B 2 3   ? -14.505 -19.956 -7.716  1    33.57  ? 173 ASN B C   1 
ATOM   2428 O  O   . ASN B 2 3   ? -14.62  -18.864 -7.154  1    34.34  ? 173 ASN B O   1 
ATOM   2429 C  CB  . ASN B 2 3   ? -12.238 -19.902 -8.8    1    35.24  ? 173 ASN B CB  1 
ATOM   2430 C  CG  . ASN B 2 3   ? -10.803 -20.406 -8.813  1    37.64  ? 173 ASN B CG  1 
ATOM   2431 O  OD1 . ASN B 2 3   ? -10.294 -20.947 -7.815  1    36.44  ? 173 ASN B OD1 1 
ATOM   2432 N  ND2 . ASN B 2 3   ? -10.119 -20.226 -9.938  1    34.34  ? 173 ASN B ND2 1 
ATOM   2433 N  N   . GLU B 2 4   ? -15.515 -20.639 -8.264  1    32.88  ? 174 GLU B N   1 
ATOM   2434 C  CA  . GLU B 2 4   ? -16.91  -20.217 -8.214  1    38.19  ? 174 GLU B CA  1 
ATOM   2435 C  C   . GLU B 2 4   ? -17.704 -21.083 -7.221  1    36.8   ? 174 GLU B C   1 
ATOM   2436 O  O   . GLU B 2 4   ? -18.92  -21.097 -7.295  1    37.91  ? 174 GLU B O   1 
ATOM   2437 C  CB  . GLU B 2 4   ? -17.59  -20.357 -9.577  1    38.3   ? 174 GLU B CB  1 
ATOM   2438 C  CG  . GLU B 2 4   ? -16.655 -20.145 -10.756 1    48.33  ? 174 GLU B CG  1 
ATOM   2439 C  CD  . GLU B 2 4   ? -17.214 -20.132 -12.171 1    57.1   ? 174 GLU B CD  1 
ATOM   2440 O  OE1 . GLU B 2 4   ? -18.029 -20.994 -12.555 1    64.34  ? 174 GLU B OE1 1 
ATOM   2441 O  OE2 . GLU B 2 4   ? -16.784 -19.236 -12.925 1    57.38  ? 174 GLU B OE2 1 
ATOM   2442 N  N   . VAL B 2 5   ? -17.017 -21.833 -6.344  1    32.83  ? 175 VAL B N   1 
ATOM   2443 C  CA  . VAL B 2 5   ? -17.583 -22.626 -5.259  1    35.46  ? 175 VAL B CA  1 
ATOM   2444 C  C   . VAL B 2 5   ? -18.927 -23.24  -5.65   1    38.7   ? 175 VAL B C   1 
ATOM   2445 O  O   . VAL B 2 5   ? -19.941 -22.938 -5.01   1    37.41  ? 175 VAL B O   1 
ATOM   2446 C  CB  . VAL B 2 5   ? -17.692 -21.907 -3.895  1    32.36  ? 175 VAL B CB  1 
ATOM   2447 C  CG1 . VAL B 2 5   ? -16.322 -21.631 -3.293  1    33.82  ? 175 VAL B CG1 1 
ATOM   2448 C  CG2 . VAL B 2 5   ? -18.486 -20.627 -3.98   1    30.46  ? 175 VAL B CG2 1 
ATOM   2449 N  N   . PRO B 2 6   ? -18.971 -24.149 -6.653  1    37.68  ? 176 PRO B N   1 
ATOM   2450 C  CA  . PRO B 2 6   ? -20.203 -24.846 -7.03   1    35.49  ? 176 PRO B CA  1 
ATOM   2451 C  C   . PRO B 2 6   ? -20.955 -25.509 -5.874  1    36.55  ? 176 PRO B C   1 
ATOM   2452 O  O   . PRO B 2 6   ? -22.179 -25.588 -5.946  1    39.14  ? 176 PRO B O   1 
ATOM   2453 C  CB  . PRO B 2 6   ? -19.772 -25.923 -8.049  1    28.82  ? 176 PRO B CB  1 
ATOM   2454 C  CG  . PRO B 2 6   ? -18.274 -26.006 -7.889  1    31.67  ? 176 PRO B CG  1 
ATOM   2455 C  CD  . PRO B 2 6   ? -17.829 -24.598 -7.461  1    35.43  ? 176 PRO B CD  1 
ATOM   2456 N  N   . ASP B 2 7   ? -20.236 -26.002 -4.843  1    32.01  ? 177 ASP B N   1 
ATOM   2457 C  CA  . ASP B 2 7   ? -20.885 -26.756 -3.778  1    32.21  ? 177 ASP B CA  1 
ATOM   2458 C  C   . ASP B 2 7   ? -21.478 -25.834 -2.708  1    32.51  ? 177 ASP B C   1 
ATOM   2459 O  O   . ASP B 2 7   ? -22.178 -26.322 -1.819  1    34.52  ? 177 ASP B O   1 
ATOM   2460 C  CB  . ASP B 2 7   ? -20.012 -27.852 -3.185  1    29.5   ? 177 ASP B CB  1 
ATOM   2461 C  CG  . ASP B 2 7   ? -20.051 -29.185 -3.921  1    34.13  ? 177 ASP B CG  1 
ATOM   2462 O  OD1 . ASP B 2 7   ? -20.482 -29.189 -5.101  1    35.49  ? 177 ASP B OD1 1 
ATOM   2463 O  OD2 . ASP B 2 7   ? -19.666 -30.232 -3.326  1    32.09  ? 177 ASP B OD2 1 
ATOM   2464 N  N   . TYR B 2 8   ? -21.223 -24.516 -2.817  1    27.51  ? 178 TYR B N   1 
ATOM   2465 C  CA  . TYR B 2 8   ? -21.551 -23.565 -1.761  1    29.18  ? 178 TYR B CA  1 
ATOM   2466 C  C   . TYR B 2 8   ? -22.172 -22.273 -2.294  1    28.35  ? 178 TYR B C   1 
ATOM   2467 O  O   . TYR B 2 8   ? -22.583 -21.461 -1.479  1    28.62  ? 178 TYR B O   1 
ATOM   2468 C  CB  . TYR B 2 8   ? -20.354 -23.187 -0.86   1    27.16  ? 178 TYR B CB  1 
ATOM   2469 C  CG  . TYR B 2 8   ? -19.681 -24.381 -0.201  1    23.93  ? 178 TYR B CG  1 
ATOM   2470 C  CD1 . TYR B 2 8   ? -20.236 -24.944 0.935   1    22.99  ? 178 TYR B CD1 1 
ATOM   2471 C  CD2 . TYR B 2 8   ? -18.57  -25.006 -0.771  1    23.36  ? 178 TYR B CD2 1 
ATOM   2472 C  CE1 . TYR B 2 8   ? -19.673 -26.056 1.54    1    22.01  ? 178 TYR B CE1 1 
ATOM   2473 C  CE2 . TYR B 2 8   ? -18.002 -26.129 -0.18   1    21.81  ? 178 TYR B CE2 1 
ATOM   2474 C  CZ  . TYR B 2 8   ? -18.544 -26.635 0.993   1    22.11  ? 178 TYR B CZ  1 
ATOM   2475 O  OH  . TYR B 2 8   ? -18.029 -27.741 1.601   1    25.55  ? 178 TYR B OH  1 
ATOM   2476 N  N   . HIS B 2 9   ? -22.301 -22.079 -3.616  1    30.01  ? 179 HIS B N   1 
ATOM   2477 C  CA  . HIS B 2 9   ? -22.78  -20.775 -4.072  1    38.44  ? 179 HIS B CA  1 
ATOM   2478 C  C   . HIS B 2 9   ? -24.218 -20.509 -3.6    1    37.42  ? 179 HIS B C   1 
ATOM   2479 O  O   . HIS B 2 9   ? -24.561 -19.366 -3.301  1    33.6   ? 179 HIS B O   1 
ATOM   2480 C  CB  . HIS B 2 9   ? -22.495 -20.516 -5.564  1    47.13  ? 179 HIS B CB  1 
ATOM   2481 C  CG  . HIS B 2 9   ? -23.39  -21.231 -6.532  1    63.36  ? 179 HIS B CG  1 
ATOM   2482 N  ND1 . HIS B 2 9   ? -23.333 -22.597 -6.776  1    63.01  ? 179 HIS B ND1 1 
ATOM   2483 C  CD2 . HIS B 2 9   ? -24.402 -20.756 -7.282  1    61.07  ? 179 HIS B CD2 1 
ATOM   2484 C  CE1 . HIS B 2 9   ? -24.268 -22.929 -7.655  1    60.89  ? 179 HIS B CE1 1 
ATOM   2485 N  NE2 . HIS B 2 9   ? -24.949 -21.834 -7.944  1    71.08  ? 179 HIS B NE2 1 
ATOM   2486 N  N   . GLU B 2 10  ? -25.079 -21.549 -3.565  1    33.3   ? 180 GLU B N   1 
ATOM   2487 C  CA  . GLU B 2 10  ? -26.459 -21.319 -3.163  1    32.6   ? 180 GLU B CA  1 
ATOM   2488 C  C   . GLU B 2 10  ? -26.523 -20.983 -1.674  1    32.28  ? 180 GLU B C   1 
ATOM   2489 O  O   . GLU B 2 10  ? -27.173 -19.998 -1.284  1    27.8   ? 180 GLU B O   1 
ATOM   2490 C  CB  . GLU B 2 10  ? -27.353 -22.528 -3.345  1    34.14  ? 180 GLU B CB  1 
ATOM   2491 C  CG  . GLU B 2 10  ? -27.978 -22.625 -4.726  1    55.07  ? 180 GLU B CG  1 
ATOM   2492 C  CD  . GLU B 2 10  ? -28.927 -23.829 -4.745  1    71.21  ? 180 GLU B CD  1 
ATOM   2493 O  OE1 . GLU B 2 10  ? -29.832 -23.941 -3.836  1    51.4   ? 180 GLU B OE1 1 
ATOM   2494 O  OE2 . GLU B 2 10  ? -28.73  -24.654 -5.696  1    73.8   ? 180 GLU B OE2 1 
ATOM   2495 N  N   . ASP B 2 11  ? -25.855 -21.831 -0.863  1    27.79  ? 181 ASP B N   1 
ATOM   2496 C  CA  . ASP B 2 11  ? -25.786 -21.628 0.57    1    26.79  ? 181 ASP B CA  1 
ATOM   2497 C  C   . ASP B 2 11  ? -25.354 -20.184 0.808   1    29.5   ? 181 ASP B C   1 
ATOM   2498 O  O   . ASP B 2 11  ? -25.95  -19.513 1.643   1    34.43  ? 181 ASP B O   1 
ATOM   2499 C  CB  . ASP B 2 11  ? -24.893 -22.629 1.282   1    30.47  ? 181 ASP B CB  1 
ATOM   2500 C  CG  . ASP B 2 11  ? -25.369 -24.071 1.468   1    36.32  ? 181 ASP B CG  1 
ATOM   2501 O  OD1 . ASP B 2 11  ? -26.559 -24.379 1.2     1    41.11  ? 181 ASP B OD1 1 
ATOM   2502 O  OD2 . ASP B 2 11  ? -24.54  -24.899 1.912   1    34.74  ? 181 ASP B OD2 1 
ATOM   2503 N  N   . ILE B 2 12  ? -24.35  -19.704 0.051   1    29.23  ? 182 ILE B N   1 
ATOM   2504 C  CA  . ILE B 2 12  ? -23.765 -18.395 0.27    1    32.86  ? 182 ILE B CA  1 
ATOM   2505 C  C   . ILE B 2 12  ? -24.754 -17.293 -0.114  1    34.68  ? 182 ILE B C   1 
ATOM   2506 O  O   . ILE B 2 12  ? -24.914 -16.315 0.623   1    35.94  ? 182 ILE B O   1 
ATOM   2507 C  CB  . ILE B 2 12  ? -22.431 -18.249 -0.474  1    33.09  ? 182 ILE B CB  1 
ATOM   2508 C  CG1 . ILE B 2 12  ? -21.341 -19.114 0.199   1    35.72  ? 182 ILE B CG1 1 
ATOM   2509 C  CG2 . ILE B 2 12  ? -21.995 -16.788 -0.526  1    28.77  ? 182 ILE B CG2 1 
ATOM   2510 C  CD1 . ILE B 2 12  ? -20.095 -19.29  -0.678  1    26.34  ? 182 ILE B CD1 1 
ATOM   2511 N  N   . HIS B 2 13  ? -25.36  -17.429 -1.293  1    29.64  ? 183 HIS B N   1 
ATOM   2512 C  CA  . HIS B 2 13  ? -26.35  -16.474 -1.758  1    31.07  ? 183 HIS B CA  1 
ATOM   2513 C  C   . HIS B 2 13  ? -27.504 -16.312 -0.754  1    32.66  ? 183 HIS B C   1 
ATOM   2514 O  O   . HIS B 2 13  ? -27.856 -15.185 -0.393  1    29.88  ? 183 HIS B O   1 
ATOM   2515 C  CB  . HIS B 2 13  ? -26.928 -16.942 -3.089  1    28.56  ? 183 HIS B CB  1 
ATOM   2516 C  CG  . HIS B 2 13  ? -27.991 -16.029 -3.57   1    31.95  ? 183 HIS B CG  1 
ATOM   2517 N  ND1 . HIS B 2 13  ? -27.696 -14.748 -3.995  1    36.21  ? 183 HIS B ND1 1 
ATOM   2518 C  CD2 . HIS B 2 13  ? -29.31  -16.176 -3.695  1    29.05  ? 183 HIS B CD2 1 
ATOM   2519 C  CE1 . HIS B 2 13  ? -28.812 -14.14  -4.368  1    34.25  ? 183 HIS B CE1 1 
ATOM   2520 N  NE2 . HIS B 2 13  ? -29.793 -15.003 -4.215  1    32.07  ? 183 HIS B NE2 1 
ATOM   2521 N  N   . THR B 2 14  ? -28.101 -17.443 -0.331  1    32.83  ? 184 THR B N   1 
ATOM   2522 C  CA  . THR B 2 14  ? -29.159 -17.466 0.672   1    34.06  ? 184 THR B CA  1 
ATOM   2523 C  C   . THR B 2 14  ? -28.741 -16.702 1.922   1    36.77  ? 184 THR B C   1 
ATOM   2524 O  O   . THR B 2 14  ? -29.542 -15.931 2.432   1    44.85  ? 184 THR B O   1 
ATOM   2525 C  CB  . THR B 2 14  ? -29.498 -18.882 1.11    1    35     ? 184 THR B CB  1 
ATOM   2526 O  OG1 . THR B 2 14  ? -30.175 -19.532 0.044   1    35.22  ? 184 THR B OG1 1 
ATOM   2527 C  CG2 . THR B 2 14  ? -30.379 -18.901 2.351   1    34.89  ? 184 THR B CG2 1 
ATOM   2528 N  N   . TYR B 2 15  ? -27.52  -16.965 2.42    1    34.74  ? 185 TYR B N   1 
ATOM   2529 C  CA  . TYR B 2 15  ? -26.975 -16.343 3.616   1    32.73  ? 185 TYR B CA  1 
ATOM   2530 C  C   . TYR B 2 15  ? -26.805 -14.833 3.433   1    34     ? 185 TYR B C   1 
ATOM   2531 O  O   . TYR B 2 15  ? -27.144 -14.081 4.351   1    34.74  ? 185 TYR B O   1 
ATOM   2532 C  CB  . TYR B 2 15  ? -25.675 -17.016 4.059   1    31.33  ? 185 TYR B CB  1 
ATOM   2533 C  CG  . TYR B 2 15  ? -25.008 -16.37  5.264   1    32.21  ? 185 TYR B CG  1 
ATOM   2534 C  CD1 . TYR B 2 15  ? -25.585 -16.4   6.545   1    34.57  ? 185 TYR B CD1 1 
ATOM   2535 C  CD2 . TYR B 2 15  ? -23.797 -15.715 5.117   1    32.26  ? 185 TYR B CD2 1 
ATOM   2536 C  CE1 . TYR B 2 15  ? -24.967 -15.803 7.642   1    34.59  ? 185 TYR B CE1 1 
ATOM   2537 C  CE2 . TYR B 2 15  ? -23.178 -15.108 6.205   1    41.13  ? 185 TYR B CE2 1 
ATOM   2538 C  CZ  . TYR B 2 15  ? -23.764 -15.135 7.469   1    39.11  ? 185 TYR B CZ  1 
ATOM   2539 O  OH  . TYR B 2 15  ? -23.052 -14.518 8.475   1    42.28  ? 185 TYR B OH  1 
ATOM   2540 N  N   . LEU B 2 16  ? -26.284 -14.398 2.272   1    29.51  ? 186 LEU B N   1 
ATOM   2541 C  CA  . LEU B 2 16  ? -26.092 -12.981 2.017   1    29.33  ? 186 LEU B CA  1 
ATOM   2542 C  C   . LEU B 2 16  ? -27.44  -12.266 1.971   1    36.06  ? 186 LEU B C   1 
ATOM   2543 O  O   . LEU B 2 16  ? -27.55  -11.106 2.398   1    37.22  ? 186 LEU B O   1 
ATOM   2544 C  CB  . LEU B 2 16  ? -25.316 -12.784 0.726   1    26.52  ? 186 LEU B CB  1 
ATOM   2545 C  CG  . LEU B 2 16  ? -23.846 -13.197 0.767   1    28.49  ? 186 LEU B CG  1 
ATOM   2546 C  CD1 . LEU B 2 16  ? -23.272 -13.126 -0.647  1    29.79  ? 186 LEU B CD1 1 
ATOM   2547 C  CD2 . LEU B 2 16  ? -23.019 -12.364 1.737   1    25.71  ? 186 LEU B CD2 1 
ATOM   2548 N  N   . ARG B 2 17  ? -28.465 -12.971 1.464   1    34.86  ? 187 ARG B N   1 
ATOM   2549 C  CA  . ARG B 2 17  ? -29.816 -12.437 1.399   1    34.5   ? 187 ARG B CA  1 
ATOM   2550 C  C   . ARG B 2 17  ? -30.379 -12.217 2.804   1    37.68  ? 187 ARG B C   1 
ATOM   2551 O  O   . ARG B 2 17  ? -31.067 -11.236 3.065   1    41.76  ? 187 ARG B O   1 
ATOM   2552 C  CB  . ARG B 2 17  ? -30.72  -13.364 0.581   1    30.78  ? 187 ARG B CB  1 
ATOM   2553 C  CG  . ARG B 2 17  ? -30.563 -13.195 -0.926  1    31.21  ? 187 ARG B CG  1 
ATOM   2554 C  CD  . ARG B 2 17  ? -31.085 -11.872 -1.476  1    27.98  ? 187 ARG B CD  1 
ATOM   2555 N  NE  . ARG B 2 17  ? -32.549 -11.808 -1.397  1    28.56  ? 187 ARG B NE  1 
ATOM   2556 C  CZ  . ARG B 2 17  ? -33.385 -12.4   -2.255  1    29.83  ? 187 ARG B CZ  1 
ATOM   2557 N  NH1 . ARG B 2 17  ? -32.936 -12.908 -3.396  1    30.65  ? 187 ARG B NH1 1 
ATOM   2558 N  NH2 . ARG B 2 17  ? -34.677 -12.437 -2.01   1    21.35  ? 187 ARG B NH2 1 
ATOM   2559 N  N   . GLU B 2 18  ? -30.111 -13.157 3.705   1    36.39  ? 188 GLU B N   1 
ATOM   2560 C  CA  . GLU B 2 18  ? -30.493 -13.025 5.102   1    37.55  ? 188 GLU B CA  1 
ATOM   2561 C  C   . GLU B 2 18  ? -29.716 -11.859 5.74    1    37.35  ? 188 GLU B C   1 
ATOM   2562 O  O   . GLU B 2 18  ? -30.286 -11.036 6.447   1    35.74  ? 188 GLU B O   1 
ATOM   2563 C  CB  . GLU B 2 18  ? -30.402 -14.435 5.699   1    36.51  ? 188 GLU B CB  1 
ATOM   2564 C  CG  . GLU B 2 18  ? -30.474 -14.502 7.221   1    50.35  ? 188 GLU B CG  1 
ATOM   2565 C  CD  . GLU B 2 18  ? -30.203 -15.878 7.82    1    63.88  ? 188 GLU B CD  1 
ATOM   2566 O  OE1 . GLU B 2 18  ? -29.879 -16.835 7.052   1    58.09  ? 188 GLU B OE1 1 
ATOM   2567 O  OE2 . GLU B 2 18  ? -30.35  -15.984 9.07    1    65.56  ? 188 GLU B OE2 1 
ATOM   2568 N  N   . MET B 2 19  ? -28.416 -11.757 5.454   1    33.98  ? 189 MET B N   1 
ATOM   2569 C  CA  . MET B 2 19  ? -27.554 -10.799 6.127   1    40.69  ? 189 MET B CA  1 
ATOM   2570 C  C   . MET B 2 19  ? -27.791 -9.363  5.647   1    38.79  ? 189 MET B C   1 
ATOM   2571 O  O   . MET B 2 19  ? -27.576 -8.437  6.408   1    36.67  ? 189 MET B O   1 
ATOM   2572 C  CB  . MET B 2 19  ? -26.074 -11.198 6.022   1    35.43  ? 189 MET B CB  1 
ATOM   2573 C  CG  . MET B 2 19  ? -25.648 -12.33  6.945   1    40.51  ? 189 MET B CG  1 
ATOM   2574 S  SD  . MET B 2 19  ? -26.172 -12.202 8.674   1    50.62  ? 189 MET B SD  1 
ATOM   2575 C  CE  . MET B 2 19  ? -27.353 -13.553 8.876   1    49.59  ? 189 MET B CE  1 
ATOM   2576 N  N   . GLU B 2 20  ? -28.264 -9.16   4.415   1    38.5   ? 190 GLU B N   1 
ATOM   2577 C  CA  . GLU B 2 20  ? -28.479 -7.806  3.926   1    39.46  ? 190 GLU B CA  1 
ATOM   2578 C  C   . GLU B 2 20  ? -29.674 -7.154  4.633   1    39.49  ? 190 GLU B C   1 
ATOM   2579 O  O   . GLU B 2 20  ? -29.646 -5.942  4.87    1    40.52  ? 190 GLU B O   1 
ATOM   2580 C  CB  . GLU B 2 20  ? -28.537 -7.773  2.397   1    34.06  ? 190 GLU B CB  1 
ATOM   2581 C  CG  . GLU B 2 20  ? -29.926 -8.045  1.832   1    42.25  ? 190 GLU B CG  1 
ATOM   2582 C  CD  . GLU B 2 20  ? -29.912 -8.083  0.318   1    42.21  ? 190 GLU B CD  1 
ATOM   2583 O  OE1 . GLU B 2 20  ? -29.128 -7.329  -0.292  1    38.64  ? 190 GLU B OE1 1 
ATOM   2584 O  OE2 . GLU B 2 20  ? -30.661 -8.888  -0.24   1    38.61  ? 190 GLU B OE2 1 
ATOM   2585 N  N   . VAL B 2 21  ? -30.701 -7.951  4.966   1    38.18  ? 191 VAL B N   1 
ATOM   2586 C  CA  . VAL B 2 21  ? -31.845 -7.509  5.749   1    41.51  ? 191 VAL B CA  1 
ATOM   2587 C  C   . VAL B 2 21  ? -31.433 -7.13   7.182   1    46.48  ? 191 VAL B C   1 
ATOM   2588 O  O   . VAL B 2 21  ? -31.904 -6.133  7.719   1    57.91  ? 191 VAL B O   1 
ATOM   2589 C  CB  . VAL B 2 21  ? -32.99  -8.553  5.713   1    38.03  ? 191 VAL B CB  1 
ATOM   2590 C  CG1 . VAL B 2 21  ? -34.174 -8.143  6.568   1    24.17  ? 191 VAL B CG1 1 
ATOM   2591 C  CG2 . VAL B 2 21  ? -33.501 -8.8    4.302   1    31.98  ? 191 VAL B CG2 1 
ATOM   2592 N  N   . LYS B 2 22  ? -30.526 -7.897  7.79    1    52.69  ? 192 LYS B N   1 
ATOM   2593 C  CA  . LYS B 2 22  ? -30.053 -7.646  9.146   1    54.59  ? 192 LYS B CA  1 
ATOM   2594 C  C   . LYS B 2 22  ? -29.063 -6.479  9.221   1    50.82  ? 192 LYS B C   1 
ATOM   2595 O  O   . LYS B 2 22  ? -28.965 -5.885  10.275  1    56.6   ? 192 LYS B O   1 
ATOM   2596 C  CB  . LYS B 2 22  ? -29.414 -8.9    9.761   1    57.35  ? 192 LYS B CB  1 
ATOM   2597 C  CG  . LYS B 2 22  ? -30.358 -10.09  9.841   1    65.31  ? 192 LYS B CG  1 
ATOM   2598 C  CD  . LYS B 2 22  ? -29.743 -11.367 10.418  1    68.83  ? 192 LYS B CD  1 
ATOM   2599 C  CE  . LYS B 2 22  ? -30.708 -12.539 10.345  1    68.21  ? 192 LYS B CE  1 
ATOM   2600 N  NZ  . LYS B 2 22  ? -30.389 -13.587 11.307  1    69.59  ? 192 LYS B NZ  1 
ATOM   2601 N  N   . CYS B 2 23  ? -28.314 -6.181  8.146   1    50.45  ? 193 CYS B N   1 
ATOM   2602 C  CA  . CYS B 2 23  ? -27.261 -5.161  8.122   1    51.63  ? 193 CYS B CA  1 
ATOM   2603 C  C   . CYS B 2 23  ? -27.755 -3.874  7.445   1    49.62  ? 193 CYS B C   1 
ATOM   2604 O  O   . CYS B 2 23  ? -26.956 -3.025  7.046   1    53.66  ? 193 CYS B O   1 
ATOM   2605 C  CB  . CYS B 2 23  ? -26.042 -5.64   7.307   1    55.62  ? 193 CYS B CB  1 
ATOM   2606 S  SG  . CYS B 2 23  ? -24.908 -6.813  8.142   1    61.7   ? 193 CYS B SG  1 
ATOM   2607 N  N   . LYS B 2 24  ? -29.07  -3.751  7.262   1    42.23  ? 194 LYS B N   1 
ATOM   2608 C  CA  . LYS B 2 24  ? -29.595 -2.687  6.431   1    42.62  ? 194 LYS B CA  1 
ATOM   2609 C  C   . LYS B 2 24  ? -29.621 -1.385  7.232   1    43.84  ? 194 LYS B C   1 
ATOM   2610 O  O   . LYS B 2 24  ? -29.914 -1.37   8.426   1    43.83  ? 194 LYS B O   1 
ATOM   2611 C  CB  . LYS B 2 24  ? -31.024 -3.037  6.021   1    47.53  ? 194 LYS B CB  1 
ATOM   2612 C  CG  . LYS B 2 24  ? -31.46  -2.487  4.683   1    65.05  ? 194 LYS B CG  1 
ATOM   2613 C  CD  . LYS B 2 24  ? -32.953 -2.129  4.713   1    67.88  ? 194 LYS B CD  1 
ATOM   2614 C  CE  . LYS B 2 24  ? -33.818 -3.176  5.387   1    68.58  ? 194 LYS B CE  1 
ATOM   2615 N  NZ  . LYS B 2 24  ? -35.142 -3.347  4.774   1    66.24  ? 194 LYS B NZ  1 
ATOM   2616 N  N   . PRO B 2 25  ? -29.314 -0.233  6.584   1    38.88  ? 195 PRO B N   1 
ATOM   2617 C  CA  . PRO B 2 25  ? -29.422 1.039   7.259   1    36.16  ? 195 PRO B CA  1 
ATOM   2618 C  C   . PRO B 2 25  ? -30.871 1.449   7.326   1    32.02  ? 195 PRO B C   1 
ATOM   2619 O  O   . PRO B 2 25  ? -31.721 0.828   6.678   1    41.66  ? 195 PRO B O   1 
ATOM   2620 C  CB  . PRO B 2 25  ? -28.61  1.961   6.345   1    38.07  ? 195 PRO B CB  1 
ATOM   2621 C  CG  . PRO B 2 25  ? -27.775 1.04    5.508   1    36.3   ? 195 PRO B CG  1 
ATOM   2622 C  CD  . PRO B 2 25  ? -28.776 -0.04   5.223   1    36.36  ? 195 PRO B CD  1 
ATOM   2623 N  N   . LYS B 2 26  ? -31.151 2.497   8.088   1    32.55  ? 196 LYS B N   1 
ATOM   2624 C  CA  . LYS B 2 26  ? -32.526 3.028   8.163   1    35.72  ? 196 LYS B CA  1 
ATOM   2625 C  C   . LYS B 2 26  ? -32.771 3.925   6.955   1    41.1   ? 196 LYS B C   1 
ATOM   2626 O  O   . LYS B 2 26  ? -32.065 4.93    6.815   1    43.3   ? 196 LYS B O   1 
ATOM   2627 C  CB  . LYS B 2 26  ? -32.738 3.893   9.403   1    38.73  ? 196 LYS B CB  1 
ATOM   2628 C  CG  . LYS B 2 26  ? -32.631 3.211   10.752  1    60     ? 196 LYS B CG  1 
ATOM   2629 C  CD  . LYS B 2 26  ? -32.768 4.225   11.881  1    71.47  ? 196 LYS B CD  1 
ATOM   2630 C  CE  . LYS B 2 26  ? -32.449 3.659   13.227  1    81.15  ? 196 LYS B CE  1 
ATOM   2631 N  NZ  . LYS B 2 26  ? -32.278 4.717   14.228  1    67.43  ? 196 LYS B NZ  1 
ATOM   2632 N  N   . VAL B 2 27  ? -33.726 3.555   6.113   1    42.92  ? 197 VAL B N   1 
ATOM   2633 C  CA  . VAL B 2 27  ? -34.089 4.432   4.971   1    40.93  ? 197 VAL B CA  1 
ATOM   2634 C  C   . VAL B 2 27  ? -34.514 5.767   5.577   1    44.63  ? 197 VAL B C   1 
ATOM   2635 O  O   . VAL B 2 27  ? -35.415 5.771   6.434   1    44.98  ? 197 VAL B O   1 
ATOM   2636 C  CB  . VAL B 2 27  ? -35.229 3.818   4.15    1    44.09  ? 197 VAL B CB  1 
ATOM   2637 C  CG1 . VAL B 2 27  ? -35.413 4.537   2.821   1    34.12  ? 197 VAL B CG1 1 
ATOM   2638 C  CG2 . VAL B 2 27  ? -35.038 2.322   3.948   1    50.71  ? 197 VAL B CG2 1 
ATOM   2639 N  N   . GLY B 2 28  ? -33.868 6.849   5.171   1    45.49  ? 198 GLY B N   1 
ATOM   2640 C  CA  . GLY B 2 28  ? -34.293 8.161   5.679   1    59.16  ? 198 GLY B CA  1 
ATOM   2641 C  C   . GLY B 2 28  ? -33.767 8.422   7.07    1    65.96  ? 198 GLY B C   1 
ATOM   2642 O  O   . GLY B 2 28  ? -34.551 8.874   7.927   1    63.73  ? 198 GLY B O   1 
ATOM   2643 N  N   . TYR B 2 29  ? -32.491 8.138   7.294   1    51.14  ? 199 TYR B N   1 
ATOM   2644 C  CA  . TYR B 2 29  ? -31.883 8.491   8.596   1    40.06  ? 199 TYR B CA  1 
ATOM   2645 C  C   . TYR B 2 29  ? -31.479 9.941   8.482   1    37.4   ? 199 TYR B C   1 
ATOM   2646 O  O   . TYR B 2 29  ? -31.254 10.591  9.512   1    38.79  ? 199 TYR B O   1 
ATOM   2647 C  CB  . TYR B 2 29  ? -30.725 7.526   8.876   1    33.76  ? 199 TYR B CB  1 
ATOM   2648 C  CG  . TYR B 2 29  ? -29.513 7.58    7.954   1    29.09  ? 199 TYR B CG  1 
ATOM   2649 C  CD1 . TYR B 2 29  ? -28.676 8.686   7.924   1    30.08  ? 199 TYR B CD1 1 
ATOM   2650 C  CD2 . TYR B 2 29  ? -29.186 6.503   7.144   1    28.2   ? 199 TYR B CD2 1 
ATOM   2651 C  CE1 . TYR B 2 29  ? -27.578 8.739   7.087   1    33.99  ? 199 TYR B CE1 1 
ATOM   2652 C  CE2 . TYR B 2 29  ? -28.081 6.536   6.312   1    34.25  ? 199 TYR B CE2 1 
ATOM   2653 C  CZ  . TYR B 2 29  ? -27.274 7.656   6.285   1    37.53  ? 199 TYR B CZ  1 
ATOM   2654 O  OH  . TYR B 2 29  ? -26.183 7.704   5.471   1    38.24  ? 199 TYR B OH  1 
ATOM   2655 N  N   . MET B 2 30  ? -31.417 10.445  7.25    1    32.46  ? 200 MET B N   1 
ATOM   2656 C  CA  . MET B 2 30  ? -30.928 11.827  7.023   1    36.53  ? 200 MET B CA  1 
ATOM   2657 C  C   . MET B 2 30  ? -31.961 12.827  7.546   1    39.54  ? 200 MET B C   1 
ATOM   2658 O  O   . MET B 2 30  ? -31.559 13.871  8.073   1    37.16  ? 200 MET B O   1 
ATOM   2659 C  CB  . MET B 2 30  ? -30.65  12.043  5.536   1    35.75  ? 200 MET B CB  1 
ATOM   2660 C  CG  . MET B 2 30  ? -29.515 12.995  5.27    1    39.57  ? 200 MET B CG  1 
ATOM   2661 S  SD  . MET B 2 30  ? -27.984 12.474  6.063   1    40.66  ? 200 MET B SD  1 
ATOM   2662 C  CE  . MET B 2 30  ? -27.258 11.511  4.733   1    39.77  ? 200 MET B CE  1 
ATOM   2663 N  N   . LYS B 2 31  ? -33.239 12.5    7.409   1    42.7   ? 201 LYS B N   1 
ATOM   2664 C  CA  . LYS B 2 31  ? -34.263 13.358  7.972   1    45.8   ? 201 LYS B CA  1 
ATOM   2665 C  C   . LYS B 2 31  ? -34.012 13.567  9.463   1    45.74  ? 201 LYS B C   1 
ATOM   2666 O  O   . LYS B 2 31  ? -34.323 14.631  9.986   1    51.47  ? 201 LYS B O   1 
ATOM   2667 C  CB  . LYS B 2 31  ? -35.644 12.757  7.692   1    47.04  ? 201 LYS B CB  1 
ATOM   2668 C  CG  . LYS B 2 31  ? -36.098 12.733  6.238   1    61.58  ? 201 LYS B CG  1 
ATOM   2669 C  CD  . LYS B 2 31  ? -37.375 11.899  6.09    1    73.3   ? 201 LYS B CD  1 
ATOM   2670 C  CE  . LYS B 2 31  ? -37.502 11.113  4.815   1    78.41  ? 201 LYS B CE  1 
ATOM   2671 N  NZ  . LYS B 2 31  ? -37.837 9.703   5.087   1    80.84  ? 201 LYS B NZ  1 
ATOM   2672 N  N   . LYS B 2 32  ? -33.439 12.565  10.145  1    50.55  ? 202 LYS B N   1 
ATOM   2673 C  CA  . LYS B 2 32  ? -33.193 12.643  11.583  1    51.72  ? 202 LYS B CA  1 
ATOM   2674 C  C   . LYS B 2 32  ? -31.742 13.037  11.881  1    48.93  ? 202 LYS B C   1 
ATOM   2675 O  O   . LYS B 2 32  ? -31.308 12.935  13.016  1    48.01  ? 202 LYS B O   1 
ATOM   2676 C  CB  . LYS B 2 32  ? -33.521 11.315  12.274  1    59.96  ? 202 LYS B CB  1 
ATOM   2677 C  CG  . LYS B 2 32  ? -34.874 10.743  11.869  1    73.72  ? 202 LYS B CG  1 
ATOM   2678 C  CD  . LYS B 2 32  ? -35.492 9.826   12.911  1    77.59  ? 202 LYS B CD  1 
ATOM   2679 C  CE  . LYS B 2 32  ? -36.279 8.764   12.207  1    80.97  ? 202 LYS B CE  1 
ATOM   2680 N  NZ  . LYS B 2 32  ? -36.908 7.787   13.088  1    82.77  ? 202 LYS B NZ  1 
ATOM   2681 N  N   . GLN B 2 33  ? -30.984 13.479  10.865  1    42.98  ? 203 GLN B N   1 
ATOM   2682 C  CA  . GLN B 2 33  ? -29.65  14.031  11.076  1    34.06  ? 203 GLN B CA  1 
ATOM   2683 C  C   . GLN B 2 33  ? -29.736 15.561  11.024  1    30.78  ? 203 GLN B C   1 
ATOM   2684 O  O   . GLN B 2 33  ? -29.974 16.142  9.965   1    32.92  ? 203 GLN B O   1 
ATOM   2685 C  CB  . GLN B 2 33  ? -28.695 13.398  10.06   1    28.62  ? 203 GLN B CB  1 
ATOM   2686 C  CG  . GLN B 2 33  ? -28.294 11.966  10.397  1    31.04  ? 203 GLN B CG  1 
ATOM   2687 C  CD  . GLN B 2 33  ? -27.1   11.839  11.33   1    29     ? 203 GLN B CD  1 
ATOM   2688 O  OE1 . GLN B 2 33  ? -26.626 12.807  11.935  1    25.9   ? 203 GLN B OE1 1 
ATOM   2689 N  NE2 . GLN B 2 33  ? -26.621 10.614  11.484  1    27.23  ? 203 GLN B NE2 1 
ATOM   2690 N  N   . PRO B 2 34  ? -29.645 16.282  12.163  1    32.4   ? 204 PRO B N   1 
ATOM   2691 C  CA  . PRO B 2 34  ? -29.9   17.726  12.166  1    31.96  ? 204 PRO B CA  1 
ATOM   2692 C  C   . PRO B 2 34  ? -28.967 18.513  11.259  1    30.83  ? 204 PRO B C   1 
ATOM   2693 O  O   . PRO B 2 34  ? -29.408 19.455  10.63   1    34.84  ? 204 PRO B O   1 
ATOM   2694 C  CB  . PRO B 2 34  ? -29.754 18.152  13.627  1    29.23  ? 204 PRO B CB  1 
ATOM   2695 C  CG  . PRO B 2 34  ? -28.919 17.042  14.233  1    31.5   ? 204 PRO B CG  1 
ATOM   2696 C  CD  . PRO B 2 34  ? -29.372 15.773  13.517  1    32.14  ? 204 PRO B CD  1 
ATOM   2697 N  N   . ASP B 2 35  ? -27.696 18.109  11.182  1    32.18  ? 205 ASP B N   1 
ATOM   2698 C  CA  . ASP B 2 35  ? -26.672 18.971  10.623  1    31     ? 205 ASP B CA  1 
ATOM   2699 C  C   . ASP B 2 35  ? -26.096 18.452  9.306   1    32.97  ? 205 ASP B C   1 
ATOM   2700 O  O   . ASP B 2 35  ? -25.295 19.146  8.679   1    35.72  ? 205 ASP B O   1 
ATOM   2701 C  CB  . ASP B 2 35  ? -25.556 19.209  11.616  1    33.92  ? 205 ASP B CB  1 
ATOM   2702 C  CG  . ASP B 2 35  ? -24.713 20.421  11.27   1    39.78  ? 205 ASP B CG  1 
ATOM   2703 O  OD1 . ASP B 2 35  ? -25.319 21.494  11.046  1    37.98  ? 205 ASP B OD1 1 
ATOM   2704 O  OD2 . ASP B 2 35  ? -23.467 20.273  11.215  1    46.06  ? 205 ASP B OD2 1 
ATOM   2705 N  N   . ILE B 2 36  ? -26.492 17.247  8.895   1    32.91  ? 206 ILE B N   1 
ATOM   2706 C  CA  . ILE B 2 36  ? -26.056 16.705  7.618   1    34.88  ? 206 ILE B CA  1 
ATOM   2707 C  C   . ILE B 2 36  ? -27.237 16.264  6.74    1    35.11  ? 206 ILE B C   1 
ATOM   2708 O  O   . ILE B 2 36  ? -28.374 16.065  7.2     1    36.12  ? 206 ILE B O   1 
ATOM   2709 C  CB  . ILE B 2 36  ? -24.985 15.618  7.811   1    33.84  ? 206 ILE B CB  1 
ATOM   2710 C  CG1 . ILE B 2 36  ? -25.538 14.392  8.473   1    31.55  ? 206 ILE B CG1 1 
ATOM   2711 C  CG2 . ILE B 2 36  ? -23.786 16.18   8.577   1    36.57  ? 206 ILE B CG2 1 
ATOM   2712 C  CD1 . ILE B 2 36  ? -24.504 13.305  8.663   1    38.43  ? 206 ILE B CD1 1 
ATOM   2713 N  N   . THR B 2 37  ? -26.915 16.112  5.449   1    32.31  ? 207 THR B N   1 
ATOM   2714 C  CA  . THR B 2 37  ? -27.854 15.99   4.345   1    31.53  ? 207 THR B CA  1 
ATOM   2715 C  C   . THR B 2 37  ? -27.345 14.927  3.388   1    30.09  ? 207 THR B C   1 
ATOM   2716 O  O   . THR B 2 37  ? -26.163 14.591  3.406   1    30.86  ? 207 THR B O   1 
ATOM   2717 C  CB  . THR B 2 37  ? -27.938 17.287  3.529   1    31.01  ? 207 THR B CB  1 
ATOM   2718 O  OG1 . THR B 2 37  ? -26.684 17.457  2.861   1    26.96  ? 207 THR B OG1 1 
ATOM   2719 C  CG2 . THR B 2 37  ? -28.325 18.502  4.347   1    25.33  ? 207 THR B CG2 1 
ATOM   2720 N  N   . ASN B 2 38  ? -28.231 14.514  2.479   1    28.43  ? 208 ASN B N   1 
ATOM   2721 C  CA  . ASN B 2 38  ? -27.894 13.59   1.413   1    30.01  ? 208 ASN B CA  1 
ATOM   2722 C  C   . ASN B 2 38  ? -26.762 14.154  0.545   1    34.14  ? 208 ASN B C   1 
ATOM   2723 O  O   . ASN B 2 38  ? -25.856 13.408  0.139   1    31.32  ? 208 ASN B O   1 
ATOM   2724 C  CB  . ASN B 2 38  ? -29.118 13.265  0.573   1    32.2   ? 208 ASN B CB  1 
ATOM   2725 C  CG  . ASN B 2 38  ? -30.101 12.416  1.344   1    35.63  ? 208 ASN B CG  1 
ATOM   2726 O  OD1 . ASN B 2 38  ? -29.69  11.506  2.077   1    37.91  ? 208 ASN B OD1 1 
ATOM   2727 N  ND2 . ASN B 2 38  ? -31.385 12.676  1.174   1    34.11  ? 208 ASN B ND2 1 
ATOM   2728 N  N   . SER B 2 39  ? -26.797 15.478  0.336   1    28.63  ? 209 SER B N   1 
ATOM   2729 C  CA  . SER B 2 39  ? -25.843 16.135  -0.526  1    32.97  ? 209 SER B CA  1 
ATOM   2730 C  C   . SER B 2 39  ? -24.442 16.079  0.08    1    36.04  ? 209 SER B C   1 
ATOM   2731 O  O   . SER B 2 39  ? -23.455 15.942  -0.648  1    36.19  ? 209 SER B O   1 
ATOM   2732 C  CB  . SER B 2 39  ? -26.281 17.533  -0.839  1    36.19  ? 209 SER B CB  1 
ATOM   2733 O  OG  . SER B 2 39  ? -25.292 18.152  -1.648  1    41.75  ? 209 SER B OG  1 
ATOM   2734 N  N   . MET B 2 40  ? -24.357 16.178  1.412   1    36.98  ? 210 MET B N   1 
ATOM   2735 C  CA  . MET B 2 40  ? -23.071 16.059  2.089   1    33.27  ? 210 MET B CA  1 
ATOM   2736 C  C   . MET B 2 40  ? -22.574 14.627  2.005   1    32.81  ? 210 MET B C   1 
ATOM   2737 O  O   . MET B 2 40  ? -21.373 14.403  1.847   1    37.78  ? 210 MET B O   1 
ATOM   2738 C  CB  . MET B 2 40  ? -23.167 16.458  3.561   1    33.44  ? 210 MET B CB  1 
ATOM   2739 C  CG  . MET B 2 40  ? -23.366 17.942  3.733   1    37.56  ? 210 MET B CG  1 
ATOM   2740 S  SD  . MET B 2 40  ? -23.621 18.348  5.464   1    37.6   ? 210 MET B SD  1 
ATOM   2741 C  CE  . MET B 2 40  ? -24.477 19.914  5.215   1    32.47  ? 210 MET B CE  1 
ATOM   2742 N  N   . ARG B 2 41  ? -23.501 13.671  2.143   1    30.76  ? 211 ARG B N   1 
ATOM   2743 C  CA  . ARG B 2 41  ? -23.125 12.268  2.112   1    30.68  ? 211 ARG B CA  1 
ATOM   2744 C  C   . ARG B 2 41  ? -22.55  11.947  0.737   1    33.57  ? 211 ARG B C   1 
ATOM   2745 O  O   . ARG B 2 41  ? -21.603 11.17   0.636   1    35.31  ? 211 ARG B O   1 
ATOM   2746 C  CB  . ARG B 2 41  ? -24.355 11.395  2.355   1    30.39  ? 211 ARG B CB  1 
ATOM   2747 C  CG  . ARG B 2 41  ? -24.101 9.9     2.234   1    29.72  ? 211 ARG B CG  1 
ATOM   2748 C  CD  . ARG B 2 41  ? -25.42  9.166   2.45    1    35.62  ? 211 ARG B CD  1 
ATOM   2749 N  NE  . ARG B 2 41  ? -25.27  7.737   2.157   1    38.65  ? 211 ARG B NE  1 
ATOM   2750 C  CZ  . ARG B 2 41  ? -25.004 7.281   0.94    1    36.43  ? 211 ARG B CZ  1 
ATOM   2751 N  NH1 . ARG B 2 41  ? -25.092 8.103   -0.1    1    33.2   ? 211 ARG B NH1 1 
ATOM   2752 N  NH2 . ARG B 2 41  ? -24.672 6.008   0.775   1    33.01  ? 211 ARG B NH2 1 
ATOM   2753 N  N   . ALA B 2 42  ? -23.143 12.558  -0.31   1    34.66  ? 212 ALA B N   1 
ATOM   2754 C  CA  . ALA B 2 42  ? -22.757 12.364  -1.697  1    28.92  ? 212 ALA B CA  1 
ATOM   2755 C  C   . ALA B 2 42  ? -21.326 12.857  -1.916  1    28.84  ? 212 ALA B C   1 
ATOM   2756 O  O   . ALA B 2 42  ? -20.535 12.207  -2.589  1    29.37  ? 212 ALA B O   1 
ATOM   2757 C  CB  . ALA B 2 42  ? -23.736 13.087  -2.576  1    27.03  ? 212 ALA B CB  1 
ATOM   2758 N  N   . ILE B 2 43  ? -21.001 13.998  -1.308  1    27.1   ? 213 ILE B N   1 
ATOM   2759 C  CA  . ILE B 2 43  ? -19.664 14.538  -1.358  1    26.95  ? 213 ILE B CA  1 
ATOM   2760 C  C   . ILE B 2 43  ? -18.675 13.559  -0.717  1    31.48  ? 213 ILE B C   1 
ATOM   2761 O  O   . ILE B 2 43  ? -17.586 13.326  -1.248  1    36.22  ? 213 ILE B O   1 
ATOM   2762 C  CB  . ILE B 2 43  ? -19.657 15.919  -0.693  1    26.34  ? 213 ILE B CB  1 
ATOM   2763 C  CG1 . ILE B 2 43  ? -20.486 16.914  -1.529  1    22.47  ? 213 ILE B CG1 1 
ATOM   2764 C  CG2 . ILE B 2 43  ? -18.221 16.403  -0.474  1    25.35  ? 213 ILE B CG2 1 
ATOM   2765 C  CD1 . ILE B 2 43  ? -20.567 18.3    -0.937  1    18.16  ? 213 ILE B CD1 1 
ATOM   2766 N  N   . LEU B 2 44  ? -19.05  12.986  0.423   1    28.25  ? 214 LEU B N   1 
ATOM   2767 C  CA  . LEU B 2 44  ? -18.155 12.094  1.143   1    29.83  ? 214 LEU B CA  1 
ATOM   2768 C  C   . LEU B 2 44  ? -17.93  10.839  0.316   1    36.03  ? 214 LEU B C   1 
ATOM   2769 O  O   . LEU B 2 44  ? -16.791 10.389  0.137   1    39.82  ? 214 LEU B O   1 
ATOM   2770 C  CB  . LEU B 2 44  ? -18.769 11.722  2.485   1    25.9   ? 214 LEU B CB  1 
ATOM   2771 C  CG  . LEU B 2 44  ? -18.011 10.704  3.333   1    26.18  ? 214 LEU B CG  1 
ATOM   2772 C  CD1 . LEU B 2 44  ? -16.741 11.276  3.887   1    25.96  ? 214 LEU B CD1 1 
ATOM   2773 C  CD2 . LEU B 2 44  ? -18.912 10.28   4.487   1    29.77  ? 214 LEU B CD2 1 
ATOM   2774 N  N   . VAL B 2 45  ? -19.028 10.283  -0.193  1    33.94  ? 215 VAL B N   1 
ATOM   2775 C  CA  . VAL B 2 45  ? -18.902 9.041   -0.934  1    35.68  ? 215 VAL B CA  1 
ATOM   2776 C  C   . VAL B 2 45  ? -18.027 9.264   -2.168  1    37.11  ? 215 VAL B C   1 
ATOM   2777 O  O   . VAL B 2 45  ? -17.195 8.421   -2.484  1    36.72  ? 215 VAL B O   1 
ATOM   2778 C  CB  . VAL B 2 45  ? -20.258 8.398   -1.263  1    37.14  ? 215 VAL B CB  1 
ATOM   2779 C  CG1 . VAL B 2 45  ? -20.079 7.16    -2.141  1    35.83  ? 215 VAL B CG1 1 
ATOM   2780 C  CG2 . VAL B 2 45  ? -21.025 8.05    0.024   1    33.98  ? 215 VAL B CG2 1 
ATOM   2781 N  N   . ASP B 2 46  ? -18.204 10.416  -2.838  1    33.67  ? 216 ASP B N   1 
ATOM   2782 C  CA  . ASP B 2 46  ? -17.481 10.705  -4.061  1    29.72  ? 216 ASP B CA  1 
ATOM   2783 C  C   . ASP B 2 46  ? -15.995 10.795  -3.748  1    31.2   ? 216 ASP B C   1 
ATOM   2784 O  O   . ASP B 2 46  ? -15.143 10.37   -4.542  1    32.53  ? 216 ASP B O   1 
ATOM   2785 C  CB  . ASP B 2 46  ? -17.933 12.018  -4.666  1    32.75  ? 216 ASP B CB  1 
ATOM   2786 C  CG  . ASP B 2 46  ? -17.257 12.406  -5.973  1    34.31  ? 216 ASP B CG  1 
ATOM   2787 O  OD1 . ASP B 2 46  ? -17.623 11.84   -7.026  1    41     ? 216 ASP B OD1 1 
ATOM   2788 O  OD2 . ASP B 2 46  ? -16.343 13.238  -5.925  1    34.55  ? 216 ASP B OD2 1 
ATOM   2789 N  N   . TRP B 2 47  ? -15.706 11.369  -2.576  1    32.24  ? 217 TRP B N   1 
ATOM   2790 C  CA  . TRP B 2 47  ? -14.339 11.481  -2.101  1    33.56  ? 217 TRP B CA  1 
ATOM   2791 C  C   . TRP B 2 47  ? -13.752 10.089  -1.85   1    35.69  ? 217 TRP B C   1 
ATOM   2792 O  O   . TRP B 2 47  ? -12.641 9.779   -2.314  1    39.39  ? 217 TRP B O   1 
ATOM   2793 C  CB  . TRP B 2 47  ? -14.295 12.413  -0.887  1    27.85  ? 217 TRP B CB  1 
ATOM   2794 C  CG  . TRP B 2 47  ? -12.96  12.527  -0.22   1    25.62  ? 217 TRP B CG  1 
ATOM   2795 C  CD1 . TRP B 2 47  ? -11.868 13.181  -0.693  1    27.32  ? 217 TRP B CD1 1 
ATOM   2796 C  CD2 . TRP B 2 47  ? -12.589 11.984  1.06    1    23.98  ? 217 TRP B CD2 1 
ATOM   2797 N  NE1 . TRP B 2 47  ? -10.828 13.074  0.195   1    28.31  ? 217 TRP B NE1 1 
ATOM   2798 C  CE2 . TRP B 2 47  ? -11.243 12.342  1.278   1    27.21  ? 217 TRP B CE2 1 
ATOM   2799 C  CE3 . TRP B 2 47  ? -13.262 11.241  2.025   1    26.17  ? 217 TRP B CE3 1 
ATOM   2800 C  CZ2 . TRP B 2 47  ? -10.547 11.963  2.416   1    27.39  ? 217 TRP B CZ2 1 
ATOM   2801 C  CZ3 . TRP B 2 47  ? -12.574 10.85   3.153   1    31.12  ? 217 TRP B CZ3 1 
ATOM   2802 C  CH2 . TRP B 2 47  ? -11.237 11.219  3.343   1    31.61  ? 217 TRP B CH2 1 
ATOM   2803 N  N   . LEU B 2 48  ? -14.544 9.235   -1.189  1    34.45  ? 218 LEU B N   1 
ATOM   2804 C  CA  . LEU B 2 48  ? -14.107 7.882   -0.876  1    33.92  ? 218 LEU B CA  1 
ATOM   2805 C  C   . LEU B 2 48  ? -13.781 7.133   -2.163  1    35.45  ? 218 LEU B C   1 
ATOM   2806 O  O   . LEU B 2 48  ? -12.887 6.291   -2.151  1    40.19  ? 218 LEU B O   1 
ATOM   2807 C  CB  . LEU B 2 48  ? -15.131 7.147   -0.02   1    31.09  ? 218 LEU B CB  1 
ATOM   2808 C  CG  . LEU B 2 48  ? -15.239 7.642   1.426   1    33.35  ? 218 LEU B CG  1 
ATOM   2809 C  CD1 . LEU B 2 48  ? -16.266 6.847   2.215   1    26.99  ? 218 LEU B CD1 1 
ATOM   2810 C  CD2 . LEU B 2 48  ? -13.884 7.586   2.115   1    28.38  ? 218 LEU B CD2 1 
ATOM   2811 N  N   . VAL B 2 49  ? -14.485 7.466   -3.258  1    31.53  ? 219 VAL B N   1 
ATOM   2812 C  CA  . VAL B 2 49  ? -14.243 6.857   -4.552  1    30.51  ? 219 VAL B CA  1 
ATOM   2813 C  C   . VAL B 2 49  ? -12.857 7.268   -5.035  1    34.15  ? 219 VAL B C   1 
ATOM   2814 O  O   . VAL B 2 49  ? -12.093 6.434   -5.504  1    36.91  ? 219 VAL B O   1 
ATOM   2815 C  CB  . VAL B 2 49  ? -15.317 7.226   -5.586  1    30.96  ? 219 VAL B CB  1 
ATOM   2816 C  CG1 . VAL B 2 49  ? -14.923 6.756   -6.981  1    28.52  ? 219 VAL B CG1 1 
ATOM   2817 C  CG2 . VAL B 2 49  ? -16.676 6.674   -5.182  1    29.82  ? 219 VAL B CG2 1 
ATOM   2818 N  N   . GLU B 2 50  ? -12.525 8.555   -4.9    1    40.25  ? 220 GLU B N   1 
ATOM   2819 C  CA  . GLU B 2 50  ? -11.211 9.043   -5.286  1    38.71  ? 220 GLU B CA  1 
ATOM   2820 C  C   . GLU B 2 50  ? -10.135 8.461   -4.369  1    38.89  ? 220 GLU B C   1 
ATOM   2821 O  O   . GLU B 2 50  ? -9.062  8.092   -4.824  1    42.78  ? 220 GLU B O   1 
ATOM   2822 C  CB  . GLU B 2 50  ? -11.129 10.549  -5.094  1    39.44  ? 220 GLU B CB  1 
ATOM   2823 C  CG  . GLU B 2 50  ? -11.654 11.335  -6.277  1    50.18  ? 220 GLU B CG  1 
ATOM   2824 C  CD  . GLU B 2 50  ? -11.535 12.828  -6.051  1    53.6   ? 220 GLU B CD  1 
ATOM   2825 O  OE1 . GLU B 2 50  ? -11.418 13.514  -7.1    1    63.72  ? 220 GLU B OE1 1 
ATOM   2826 O  OE2 . GLU B 2 50  ? -11.629 13.282  -4.878  1    51.35  ? 220 GLU B OE2 1 
ATOM   2827 N  N   . VAL B 2 51  ? -10.382 8.434   -3.06   1    33.72  ? 221 VAL B N   1 
ATOM   2828 C  CA  . VAL B 2 51  ? -9.385  7.834   -2.195  1    34.32  ? 221 VAL B CA  1 
ATOM   2829 C  C   . VAL B 2 51  ? -9.073  6.417   -2.675  1    35.55  ? 221 VAL B C   1 
ATOM   2830 O  O   . VAL B 2 51  ? -7.9    6.073   -2.84   1    37.9   ? 221 VAL B O   1 
ATOM   2831 C  CB  . VAL B 2 51  ? -9.859  7.861   -0.737  1    31.24  ? 221 VAL B CB  1 
ATOM   2832 C  CG1 . VAL B 2 51  ? -8.988  6.975   0.138   1    29.94  ? 221 VAL B CG1 1 
ATOM   2833 C  CG2 . VAL B 2 51  ? -9.918  9.297   -0.24   1    29.01  ? 221 VAL B CG2 1 
ATOM   2834 N  N   . GLY B 2 52  ? -10.104 5.637   -2.97   1    30.66  ? 222 GLY B N   1 
ATOM   2835 C  CA  . GLY B 2 52  ? -9.907  4.245   -3.404  1    31.98  ? 222 GLY B CA  1 
ATOM   2836 C  C   . GLY B 2 52  ? -9.09   4.121   -4.673  1    39.3   ? 222 GLY B C   1 
ATOM   2837 O  O   . GLY B 2 52  ? -8.256  3.212   -4.74   1    42.82  ? 222 GLY B O   1 
ATOM   2838 N  N   . GLU B 2 53  ? -9.332  4.985   -5.654  1    41.13  ? 223 GLU B N   1 
ATOM   2839 C  CA  . GLU B 2 53  ? -8.614  4.921   -6.949  1    42.39  ? 223 GLU B CA  1 
ATOM   2840 C  C   . GLU B 2 53  ? -7.174  5.399   -6.741  1    43.14  ? 223 GLU B C   1 
ATOM   2841 O  O   . GLU B 2 53  ? -6.272  4.884   -7.419  1    44.06  ? 223 GLU B O   1 
ATOM   2842 C  CB  . GLU B 2 53  ? -9.378  5.767   -7.963  1    41.76  ? 223 GLU B CB  1 
ATOM   2843 C  CG  . GLU B 2 53  ? -9.186  5.328   -9.411  1    39.9   ? 223 GLU B CG  1 
ATOM   2844 C  CD  . GLU B 2 53  ? -9.407  6.431   -10.433 1    39.23  ? 223 GLU B CD  1 
ATOM   2845 O  OE1 . GLU B 2 53  ? -9.724  7.565   -10.025 1    37.56  ? 223 GLU B OE1 1 
ATOM   2846 O  OE2 . GLU B 2 53  ? -9.263  6.158   -11.641 1    29.28  ? 223 GLU B OE2 1 
ATOM   2847 N  N   . GLU B 2 54  ? -6.976  6.338   -5.822  1    46.88  ? 224 GLU B N   1 
ATOM   2848 C  CA  . GLU B 2 54  ? -5.61   6.826   -5.517  1    44.79  ? 224 GLU B CA  1 
ATOM   2849 C  C   . GLU B 2 54  ? -4.824  5.672   -4.887  1    38.42  ? 224 GLU B C   1 
ATOM   2850 O  O   . GLU B 2 54  ? -3.701  5.408   -5.345  1    41.26  ? 224 GLU B O   1 
ATOM   2851 C  CB  . GLU B 2 54  ? -5.672  8.058   -4.615  1    45.95  ? 224 GLU B CB  1 
ATOM   2852 C  CG  . GLU B 2 54  ? -4.345  8.394   -3.944  1    53.42  ? 224 GLU B CG  1 
ATOM   2853 C  CD  . GLU B 2 54  ? -3.462  9.337   -4.738  1    66.46  ? 224 GLU B CD  1 
ATOM   2854 O  OE1 . GLU B 2 54  ? -3.665  9.46    -5.963  1    68.57  ? 224 GLU B OE1 1 
ATOM   2855 O  OE2 . GLU B 2 54  ? -2.568  9.951   -4.123  1    71.54  ? 224 GLU B OE2 1 
ATOM   2856 N  N   . TYR B 2 55  ? -5.401  5.014   -3.886  1    34.69  ? 225 TYR B N   1 
ATOM   2857 C  CA  . TYR B 2 55  ? -4.652  3.945   -3.237  1    35.79  ? 225 TYR B CA  1 
ATOM   2858 C  C   . TYR B 2 55  ? -4.879  2.594   -3.913  1    36.53  ? 225 TYR B C   1 
ATOM   2859 O  O   . TYR B 2 55  ? -4.447  1.577   -3.377  1    38.74  ? 225 TYR B O   1 
ATOM   2860 C  CB  . TYR B 2 55  ? -4.943  3.899   -1.73   1    37.21  ? 225 TYR B CB  1 
ATOM   2861 C  CG  . TYR B 2 55  ? -4.342  5.101   -1.018  1    45.74  ? 225 TYR B CG  1 
ATOM   2862 C  CD1 . TYR B 2 55  ? -5.03   6.315   -0.974  1    50.36  ? 225 TYR B CD1 1 
ATOM   2863 C  CD2 . TYR B 2 55  ? -3.049  5.055   -0.489  1    37.64  ? 225 TYR B CD2 1 
ATOM   2864 C  CE1 . TYR B 2 55  ? -4.451  7.432   -0.386  1    48.57  ? 225 TYR B CE1 1 
ATOM   2865 C  CE2 . TYR B 2 55  ? -2.479  6.162   0.122   1    42.01  ? 225 TYR B CE2 1 
ATOM   2866 C  CZ  . TYR B 2 55  ? -3.183  7.357   0.168   1    43.29  ? 225 TYR B CZ  1 
ATOM   2867 O  OH  . TYR B 2 55  ? -2.634  8.462   0.755   1    41.11  ? 225 TYR B OH  1 
ATOM   2868 N  N   . LYS B 2 56  ? -5.555  2.575   -5.076  1    36.33  ? 226 LYS B N   1 
ATOM   2869 C  CA  . LYS B 2 56  ? -5.763  1.345   -5.831  1    39.47  ? 226 LYS B CA  1 
ATOM   2870 C  C   . LYS B 2 56  ? -6.391  0.267   -4.929  1    43     ? 226 LYS B C   1 
ATOM   2871 O  O   . LYS B 2 56  ? -5.907  -0.868  -4.882  1    43.66  ? 226 LYS B O   1 
ATOM   2872 C  CB  . LYS B 2 56  ? -4.477  0.85    -6.514  1    46.72  ? 226 LYS B CB  1 
ATOM   2873 C  CG  . LYS B 2 56  ? -3.546  1.836   -7.238  1    59.29  ? 226 LYS B CG  1 
ATOM   2874 C  CD  . LYS B 2 56  ? -3.681  2.14    -8.728  1    80.91  ? 226 LYS B CD  1 
ATOM   2875 C  CE  . LYS B 2 56  ? -3.775  1.024   -9.732  1    89.11  ? 226 LYS B CE  1 
ATOM   2876 N  NZ  . LYS B 2 56  ? -2.452  0.435   -9.912  1    86.67  ? 226 LYS B NZ  1 
ATOM   2877 N  N   . LEU B 2 57  ? -7.494  0.629   -4.246  1    35.95  ? 227 LEU B N   1 
ATOM   2878 C  CA  . LEU B 2 57  ? -8.251  -0.224  -3.341  1    33.47  ? 227 LEU B CA  1 
ATOM   2879 C  C   . LEU B 2 57  ? -9.265  -1.02   -4.146  1    35.27  ? 227 LEU B C   1 
ATOM   2880 O  O   . LEU B 2 57  ? -9.626  -0.648  -5.246  1    41.37  ? 227 LEU B O   1 
ATOM   2881 C  CB  . LEU B 2 57  ? -8.97   0.614   -2.278  1    33.6   ? 227 LEU B CB  1 
ATOM   2882 C  CG  . LEU B 2 57  ? -8.073  1.445   -1.345  1    36.17  ? 227 LEU B CG  1 
ATOM   2883 C  CD1 . LEU B 2 57  ? -8.853  2.127   -0.245  1    29.03  ? 227 LEU B CD1 1 
ATOM   2884 C  CD2 . LEU B 2 57  ? -6.996  0.594   -0.711  1    32.83  ? 227 LEU B CD2 1 
ATOM   2885 N  N   . GLN B 2 58  ? -9.776  -2.099  -3.576  1    35.6   ? 228 GLN B N   1 
ATOM   2886 C  CA  . GLN B 2 58  ? -10.767 -2.869  -4.285  1    34.12  ? 228 GLN B CA  1 
ATOM   2887 C  C   . GLN B 2 58  ? -12.056 -2.062  -4.289  1    36.45  ? 228 GLN B C   1 
ATOM   2888 O  O   . GLN B 2 58  ? -12.249 -1.21   -3.418  1    39.56  ? 228 GLN B O   1 
ATOM   2889 C  CB  . GLN B 2 58  ? -10.923 -4.205  -3.545  1    34.44  ? 228 GLN B CB  1 
ATOM   2890 C  CG  . GLN B 2 58  ? -9.716  -5.125  -3.661  1    36.62  ? 228 GLN B CG  1 
ATOM   2891 C  CD  . GLN B 2 58  ? -9.456  -5.527  -5.102  1    36.86  ? 228 GLN B CD  1 
ATOM   2892 O  OE1 . GLN B 2 58  ? -10.36  -5.93   -5.841  1    40.15  ? 228 GLN B OE1 1 
ATOM   2893 N  NE2 . GLN B 2 58  ? -8.232  -5.334  -5.548  1    34.9   ? 228 GLN B NE2 1 
ATOM   2894 N  N   . ASN B 2 59  ? -12.943 -2.368  -5.247  1    36.82  ? 229 ASN B N   1 
ATOM   2895 C  CA  . ASN B 2 59  ? -14.31  -1.86   -5.257  1    37.82  ? 229 ASN B CA  1 
ATOM   2896 C  C   . ASN B 2 59  ? -15.056 -2.347  -4.011  1    41.29  ? 229 ASN B C   1 
ATOM   2897 O  O   . ASN B 2 59  ? -15.872 -1.617  -3.442  1    38.89  ? 229 ASN B O   1 
ATOM   2898 C  CB  . ASN B 2 59  ? -15.037 -2.217  -6.553  1    36.74  ? 229 ASN B CB  1 
ATOM   2899 C  CG  . ASN B 2 59  ? -14.61  -1.366  -7.732  1    38.2   ? 229 ASN B CG  1 
ATOM   2900 O  OD1 . ASN B 2 59  ? -13.795 -0.453  -7.579  1    37.06  ? 229 ASN B OD1 1 
ATOM   2901 N  ND2 . ASN B 2 59  ? -15.151 -1.634  -8.919  1    42.6   ? 229 ASN B ND2 1 
ATOM   2902 N  N   . GLU B 2 60  ? -14.761 -3.584  -3.577  1    36.31  ? 230 GLU B N   1 
ATOM   2903 C  CA  . GLU B 2 60  ? -15.444 -4.147  -2.425  1    35.37  ? 230 GLU B CA  1 
ATOM   2904 C  C   . GLU B 2 60  ? -15.198 -3.259  -1.204  1    36.48  ? 230 GLU B C   1 
ATOM   2905 O  O   . GLU B 2 60  ? -16.095 -3.056  -0.37   1    32.03  ? 230 GLU B O   1 
ATOM   2906 C  CB  . GLU B 2 60  ? -14.991 -5.594  -2.23   1    34.25  ? 230 GLU B CB  1 
ATOM   2907 C  CG  . GLU B 2 60  ? -15.598 -6.308  -1.028  1    33.13  ? 230 GLU B CG  1 
ATOM   2908 C  CD  . GLU B 2 60  ? -17.103 -6.428  -1.138  1    39.53  ? 230 GLU B CD  1 
ATOM   2909 O  OE1 . GLU B 2 60  ? -17.657 -6.19   -2.248  1    42.65  ? 230 GLU B OE1 1 
ATOM   2910 O  OE2 . GLU B 2 60  ? -17.712 -6.741  -0.092  1    34.44  ? 230 GLU B OE2 1 
ATOM   2911 N  N   . THR B 2 61  ? -13.968 -2.734  -1.102  1    33.97  ? 231 THR B N   1 
ATOM   2912 C  CA  . THR B 2 61  ? -13.58  -1.948  0.063   1    36.42  ? 231 THR B CA  1 
ATOM   2913 C  C   . THR B 2 61  ? -14.414 -0.669  0.137   1    37.4   ? 231 THR B C   1 
ATOM   2914 O  O   . THR B 2 61  ? -14.864 -0.307  1.217   1    33.95  ? 231 THR B O   1 
ATOM   2915 C  CB  . THR B 2 61  ? -12.091 -1.638  0.043   1    36.26  ? 231 THR B CB  1 
ATOM   2916 O  OG1 . THR B 2 61  ? -11.401 -2.84   -0.256  1    34.94  ? 231 THR B OG1 1 
ATOM   2917 C  CG2 . THR B 2 61  ? -11.631 -1.064  1.365   1    36.29  ? 231 THR B CG2 1 
ATOM   2918 N  N   . LEU B 2 62  ? -14.618 -0.023  -1.024  1    36.81  ? 232 LEU B N   1 
ATOM   2919 C  CA  . LEU B 2 62  ? -15.48  1.141   -1.144  1    33.31  ? 232 LEU B CA  1 
ATOM   2920 C  C   . LEU B 2 62  ? -16.885 0.813   -0.661  1    33.48  ? 232 LEU B C   1 
ATOM   2921 O  O   . LEU B 2 62  ? -17.408 1.542   0.183   1    34.16  ? 232 LEU B O   1 
ATOM   2922 C  CB  . LEU B 2 62  ? -15.52  1.649   -2.581  1    34.34  ? 232 LEU B CB  1 
ATOM   2923 C  CG  . LEU B 2 62  ? -16.524 2.774   -2.853  1    32.59  ? 232 LEU B CG  1 
ATOM   2924 C  CD1 . LEU B 2 62  ? -16.002 4.059   -2.217  1    29.87  ? 232 LEU B CD1 1 
ATOM   2925 C  CD2 . LEU B 2 62  ? -16.772 2.923   -4.366  1    28.99  ? 232 LEU B CD2 1 
ATOM   2926 N  N   . HIS B 2 63  ? -17.475 -0.254  -1.228  1    28.3   ? 233 HIS B N   1 
ATOM   2927 C  CA  . HIS B 2 63  ? -18.821 -0.681  -0.892  1    26.48  ? 233 HIS B CA  1 
ATOM   2928 C  C   . HIS B 2 63  ? -18.976 -0.921  0.619   1    34.85  ? 233 HIS B C   1 
ATOM   2929 O  O   . HIS B 2 63  ? -19.995 -0.531  1.216   1    32.14  ? 233 HIS B O   1 
ATOM   2930 C  CB  . HIS B 2 63  ? -19.222 -1.886  -1.736  1    25.81  ? 233 HIS B CB  1 
ATOM   2931 C  CG  . HIS B 2 63  ? -19.705 -1.558  -3.115  1    35.48  ? 233 HIS B CG  1 
ATOM   2932 N  ND1 . HIS B 2 63  ? -18.848 -1.213  -4.154  1    36.25  ? 233 HIS B ND1 1 
ATOM   2933 C  CD2 . HIS B 2 63  ? -20.945 -1.521  -3.638  1    30.22  ? 233 HIS B CD2 1 
ATOM   2934 C  CE1 . HIS B 2 63  ? -19.55  -0.974  -5.255  1    29.3   ? 233 HIS B CE1 1 
ATOM   2935 N  NE2 . HIS B 2 63  ? -20.813 -1.163  -4.961  1    31.83  ? 233 HIS B NE2 1 
ATOM   2936 N  N   . LEU B 2 64  ? -17.966 -1.565  1.237   1    30.26  ? 234 LEU B N   1 
ATOM   2937 C  CA  . LEU B 2 64  ? -18.029 -1.855  2.659   1    29.43  ? 234 LEU B CA  1 
ATOM   2938 C  C   . LEU B 2 64  ? -18.004 -0.544  3.435   1    33.48  ? 234 LEU B C   1 
ATOM   2939 O  O   . LEU B 2 64  ? -18.747 -0.345  4.39    1    38.43  ? 234 LEU B O   1 
ATOM   2940 C  CB  . LEU B 2 64  ? -16.856 -2.75   3.06    1    25.97  ? 234 LEU B CB  1 
ATOM   2941 C  CG  . LEU B 2 64  ? -16.943 -4.198  2.573   1    27.56  ? 234 LEU B CG  1 
ATOM   2942 C  CD1 . LEU B 2 64  ? -15.63  -4.911  2.727   1    27.47  ? 234 LEU B CD1 1 
ATOM   2943 C  CD2 . LEU B 2 64  ? -18.04  -4.949  3.261   1    24.72  ? 234 LEU B CD2 1 
ATOM   2944 N  N   . ALA B 2 65  ? -17.132 0.362   3.026   1    32.25  ? 235 ALA B N   1 
ATOM   2945 C  CA  . ALA B 2 65  ? -17.001 1.608   3.753   1    35.58  ? 235 ALA B CA  1 
ATOM   2946 C  C   . ALA B 2 65  ? -18.341 2.35    3.748   1    35.6   ? 235 ALA B C   1 
ATOM   2947 O  O   . ALA B 2 65  ? -18.761 2.919   4.757   1    43.16  ? 235 ALA B O   1 
ATOM   2948 C  CB  . ALA B 2 65  ? -15.884 2.432   3.109   1    32.14  ? 235 ALA B CB  1 
ATOM   2949 N  N   . VAL B 2 66  ? -19.006 2.37    2.596   1    29.97  ? 236 VAL B N   1 
ATOM   2950 C  CA  . VAL B 2 66  ? -20.251 3.099   2.494   1    35.72  ? 236 VAL B CA  1 
ATOM   2951 C  C   . VAL B 2 66  ? -21.264 2.405   3.43    1    40.05  ? 236 VAL B C   1 
ATOM   2952 O  O   . VAL B 2 66  ? -21.978 3.064   4.194   1    37.83  ? 236 VAL B O   1 
ATOM   2953 C  CB  . VAL B 2 66  ? -20.707 3.236   1.014   1    31.54  ? 236 VAL B CB  1 
ATOM   2954 C  CG1 . VAL B 2 66  ? -22.12  3.815   0.878   1    33.63  ? 236 VAL B CG1 1 
ATOM   2955 C  CG2 . VAL B 2 66  ? -19.744 4.077   0.192   1    26.19  ? 236 VAL B CG2 1 
ATOM   2956 N  N   . ASN B 2 67  ? -21.285 1.062   3.397   1    36.61  ? 237 ASN B N   1 
ATOM   2957 C  CA  . ASN B 2 67  ? -22.132 0.258   4.27    1    36.59  ? 237 ASN B CA  1 
ATOM   2958 C  C   . ASN B 2 67  ? -21.935 0.66    5.729   1    34.09  ? 237 ASN B C   1 
ATOM   2959 O  O   . ASN B 2 67  ? -22.932 0.808   6.448   1    28.63  ? 237 ASN B O   1 
ATOM   2960 C  CB  . ASN B 2 67  ? -21.913 -1.245  4.084   1    32.84  ? 237 ASN B CB  1 
ATOM   2961 C  CG  . ASN B 2 67  ? -22.705 -2.043  5.086   1    34.34  ? 237 ASN B CG  1 
ATOM   2962 O  OD1 . ASN B 2 67  ? -22.294 -2.19   6.239   1    43.94  ? 237 ASN B OD1 1 
ATOM   2963 N  ND2 . ASN B 2 67  ? -23.856 -2.557  4.694   1    37.81  ? 237 ASN B ND2 1 
ATOM   2964 N  N   . TYR B 2 68  ? -20.658 0.758   6.17    1    31.98  ? 238 TYR B N   1 
ATOM   2965 C  CA  . TYR B 2 68  ? -20.344 1.085   7.559   1    31.08  ? 238 TYR B CA  1 
ATOM   2966 C  C   . TYR B 2 68  ? -20.851 2.49    7.89    1    34.49  ? 238 TYR B C   1 
ATOM   2967 O  O   . TYR B 2 68  ? -21.437 2.718   8.96    1    29.6   ? 238 TYR B O   1 
ATOM   2968 C  CB  . TYR B 2 68  ? -18.844 1.037   7.828   1    31.06  ? 238 TYR B CB  1 
ATOM   2969 C  CG  . TYR B 2 68  ? -18.224 -0.325  7.581   1    33.23  ? 238 TYR B CG  1 
ATOM   2970 C  CD1 . TYR B 2 68  ? -19.012 -1.469  7.432   1    33.29  ? 238 TYR B CD1 1 
ATOM   2971 C  CD2 . TYR B 2 68  ? -16.848 -0.456  7.481   1    31.69  ? 238 TYR B CD2 1 
ATOM   2972 C  CE1 . TYR B 2 68  ? -18.439 -2.713  7.193   1    32.49  ? 238 TYR B CE1 1 
ATOM   2973 C  CE2 . TYR B 2 68  ? -16.272 -1.689  7.217   1    33.86  ? 238 TYR B CE2 1 
ATOM   2974 C  CZ  . TYR B 2 68  ? -17.062 -2.823  7.089   1    32.61  ? 238 TYR B CZ  1 
ATOM   2975 O  OH  . TYR B 2 68  ? -16.461 -4.033  6.845   1    33.61  ? 238 TYR B OH  1 
ATOM   2976 N  N   . ILE B 2 69  ? -20.631 3.419   6.941   1    33.02  ? 239 ILE B N   1 
ATOM   2977 C  CA  . ILE B 2 69  ? -21.003 4.811   7.144   1    33.19  ? 239 ILE B CA  1 
ATOM   2978 C  C   . ILE B 2 69  ? -22.515 4.902   7.335   1    34.09  ? 239 ILE B C   1 
ATOM   2979 O  O   . ILE B 2 69  ? -22.973 5.539   8.293   1    35.49  ? 239 ILE B O   1 
ATOM   2980 C  CB  . ILE B 2 69  ? -20.526 5.686   5.969   1    32.91  ? 239 ILE B CB  1 
ATOM   2981 C  CG1 . ILE B 2 69  ? -19.012 5.697   5.858   1    30.44  ? 239 ILE B CG1 1 
ATOM   2982 C  CG2 . ILE B 2 69  ? -21.128 7.089   6.037   1    27.71  ? 239 ILE B CG2 1 
ATOM   2983 C  CD1 . ILE B 2 69  ? -18.499 6.447   4.648   1    27.03  ? 239 ILE B CD1 1 
ATOM   2984 N  N   . ASP B 2 70  ? -23.262 4.253   6.428   1    28.82  ? 240 ASP B N   1 
ATOM   2985 C  CA  . ASP B 2 70  ? -24.713 4.374   6.408   1    31.67  ? 240 ASP B CA  1 
ATOM   2986 C  C   . ASP B 2 70  ? -25.293 3.815   7.705   1    34.25  ? 240 ASP B C   1 
ATOM   2987 O  O   . ASP B 2 70  ? -26.192 4.415   8.295   1    35.18  ? 240 ASP B O   1 
ATOM   2988 C  CB  . ASP B 2 70  ? -25.333 3.731   5.172   1    31.24  ? 240 ASP B CB  1 
ATOM   2989 C  CG  . ASP B 2 70  ? -25.212 4.52    3.879   1    33.4   ? 240 ASP B CG  1 
ATOM   2990 O  OD1 . ASP B 2 70  ? -25.375 5.766   3.938   1    34.58  ? 240 ASP B OD1 1 
ATOM   2991 O  OD2 . ASP B 2 70  ? -25.002 3.885   2.812   1    36.65  ? 240 ASP B OD2 1 
ATOM   2992 N  N   . ARG B 2 71  ? -24.765 2.659   8.135   1    32.19  ? 241 ARG B N   1 
ATOM   2993 C  CA  . ARG B 2 71  ? -25.249 2.01    9.34    1    30.82  ? 241 ARG B CA  1 
ATOM   2994 C  C   . ARG B 2 71  ? -24.882 2.839   10.565  1    30.73  ? 241 ARG B C   1 
ATOM   2995 O  O   . ARG B 2 71  ? -25.659 2.901   11.507  1    29.7   ? 241 ARG B O   1 
ATOM   2996 C  CB  . ARG B 2 71  ? -24.657 0.608   9.478   1    32.95  ? 241 ARG B CB  1 
ATOM   2997 C  CG  . ARG B 2 71  ? -25.4   -0.455  8.675   1    37.03  ? 241 ARG B CG  1 
ATOM   2998 C  CD  . ARG B 2 71  ? -24.496 -1.643  8.358   1    37.99  ? 241 ARG B CD  1 
ATOM   2999 N  NE  . ARG B 2 71  ? -24.366 -2.479  9.551   1    35.9   ? 241 ARG B NE  1 
ATOM   3000 C  CZ  . ARG B 2 71  ? -23.346 -3.287  9.773   1    34.42  ? 241 ARG B CZ  1 
ATOM   3001 N  NH1 . ARG B 2 71  ? -22.382 -3.445  8.877   1    30.24  ? 241 ARG B NH1 1 
ATOM   3002 N  NH2 . ARG B 2 71  ? -23.302 -3.931  10.922  1    38.11  ? 241 ARG B NH2 1 
ATOM   3003 N  N   . PHE B 2 72  ? -23.691 3.451   10.548  1    29.55  ? 242 PHE B N   1 
ATOM   3004 C  CA  . PHE B 2 72  ? -23.24  4.287   11.652  1    30.81  ? 242 PHE B CA  1 
ATOM   3005 C  C   . PHE B 2 72  ? -24.143 5.52    11.775  1    31.88  ? 242 PHE B C   1 
ATOM   3006 O  O   . PHE B 2 72  ? -24.555 5.871   12.87   1    34.69  ? 242 PHE B O   1 
ATOM   3007 C  CB  . PHE B 2 72  ? -21.769 4.675   11.459  1    27.44  ? 242 PHE B CB  1 
ATOM   3008 C  CG  . PHE B 2 72  ? -21.206 5.48    12.614  1    27.72  ? 242 PHE B CG  1 
ATOM   3009 C  CD1 . PHE B 2 72  ? -20.623 4.839   13.701  1    28.32  ? 242 PHE B CD1 1 
ATOM   3010 C  CD2 . PHE B 2 72  ? -21.248 6.877   12.623  1    29.27  ? 242 PHE B CD2 1 
ATOM   3011 C  CE1 . PHE B 2 72  ? -20.128 5.584   14.774  1    31.33  ? 242 PHE B CE1 1 
ATOM   3012 C  CE2 . PHE B 2 72  ? -20.728 7.616   13.688  1    27.59  ? 242 PHE B CE2 1 
ATOM   3013 C  CZ  . PHE B 2 72  ? -20.181 6.972   14.772  1    25.59  ? 242 PHE B CZ  1 
ATOM   3014 N  N   . LEU B 2 73  ? -24.461 6.17    10.651  1    32.19  ? 243 LEU B N   1 
ATOM   3015 C  CA  . LEU B 2 73  ? -25.275 7.381   10.642  1    36.28  ? 243 LEU B CA  1 
ATOM   3016 C  C   . LEU B 2 73  ? -26.73  7.041   10.984  1    39.7   ? 243 LEU B C   1 
ATOM   3017 O  O   . LEU B 2 73  ? -27.547 7.941   11.238  1    43.31  ? 243 LEU B O   1 
ATOM   3018 C  CB  . LEU B 2 73  ? -25.179 8.104   9.294   1    30.88  ? 243 LEU B CB  1 
ATOM   3019 C  CG  . LEU B 2 73  ? -23.799 8.669   8.937   1    32.88  ? 243 LEU B CG  1 
ATOM   3020 C  CD1 . LEU B 2 73  ? -23.833 9.398   7.608   1    24.6   ? 243 LEU B CD1 1 
ATOM   3021 C  CD2 . LEU B 2 73  ? -23.186 9.521   10.097  1    32.2   ? 243 LEU B CD2 1 
ATOM   3022 N  N   . SER B 2 74  ? -27.038 5.74    11.013  1    35.25  ? 244 SER B N   1 
ATOM   3023 C  CA  . SER B 2 74  ? -28.381 5.313   11.351  1    36.39  ? 244 SER B CA  1 
ATOM   3024 C  C   . SER B 2 74  ? -28.631 5.441   12.851  1    33.59  ? 244 SER B C   1 
ATOM   3025 O  O   . SER B 2 74  ? -29.767 5.692   13.239  1    33.03  ? 244 SER B O   1 
ATOM   3026 C  CB  . SER B 2 74  ? -28.682 3.939   10.835  1    39.16  ? 244 SER B CB  1 
ATOM   3027 O  OG  . SER B 2 74  ? -28.822 3.955   9.422   1    45.36  ? 244 SER B OG  1 
ATOM   3028 N  N   . SER B 2 75  ? -27.567 5.331   13.677  1    28.8   ? 245 SER B N   1 
ATOM   3029 C  CA  . SER B 2 75  ? -27.764 5.522   15.106  1    30.94  ? 245 SER B CA  1 
ATOM   3030 C  C   . SER B 2 75  ? -27.016 6.718   15.699  1    33.04  ? 245 SER B C   1 
ATOM   3031 O  O   . SER B 2 75  ? -27.322 7.104   16.839  1    38.31  ? 245 SER B O   1 
ATOM   3032 C  CB  . SER B 2 75  ? -27.602 4.282   15.931  1    28.29  ? 245 SER B CB  1 
ATOM   3033 O  OG  . SER B 2 75  ? -26.249 3.872   15.93   1    36.65  ? 245 SER B OG  1 
ATOM   3034 N  N   . MET B 2 76  ? -26.072 7.333   14.967  1    28.93  ? 246 MET B N   1 
ATOM   3035 C  CA  . MET B 2 76  ? -25.292 8.413   15.584  1    28.49  ? 246 MET B CA  1 
ATOM   3036 C  C   . MET B 2 76  ? -25.448 9.731   14.813  1    30.19  ? 246 MET B C   1 
ATOM   3037 O  O   . MET B 2 76  ? -25.232 9.767   13.593  1    31.62  ? 246 MET B O   1 
ATOM   3038 C  CB  . MET B 2 76  ? -23.807 8.05    15.661  1    26.4   ? 246 MET B CB  1 
ATOM   3039 C  CG  . MET B 2 76  ? -23.542 6.663   16.166  1    24.78  ? 246 MET B CG  1 
ATOM   3040 S  SD  . MET B 2 76  ? -23.642 6.649   17.956  1    29.12  ? 246 MET B SD  1 
ATOM   3041 C  CE  . MET B 2 76  ? -22.164 7.477   18.558  1    24.3   ? 246 MET B CE  1 
ATOM   3042 N  N   . SER B 2 77  ? -25.862 10.792  15.531  1    26.92  ? 247 SER B N   1 
ATOM   3043 C  CA  . SER B 2 77  ? -25.887 12.145  15.002  1    26.15  ? 247 SER B CA  1 
ATOM   3044 C  C   . SER B 2 77  ? -24.454 12.62   14.873  1    27.66  ? 247 SER B C   1 
ATOM   3045 O  O   . SER B 2 77  ? -23.684 12.45   15.815  1    29.74  ? 247 SER B O   1 
ATOM   3046 C  CB  . SER B 2 77  ? -26.57  13.108  15.916  1    23.85  ? 247 SER B CB  1 
ATOM   3047 O  OG  . SER B 2 77  ? -27.924 12.745  16.039  1    25.98  ? 247 SER B OG  1 
ATOM   3048 N  N   . VAL B 2 78  ? -24.154 13.269  13.745  1    27     ? 248 VAL B N   1 
ATOM   3049 C  CA  . VAL B 2 78  ? -22.809 13.723  13.433  1    28.3   ? 248 VAL B CA  1 
ATOM   3050 C  C   . VAL B 2 78  ? -22.87  15.139  12.865  1    29.91  ? 248 VAL B C   1 
ATOM   3051 O  O   . VAL B 2 78  ? -23.632 15.404  11.937  1    37.77  ? 248 VAL B O   1 
ATOM   3052 C  CB  . VAL B 2 78  ? -22.167 12.739  12.441  1    28.73  ? 248 VAL B CB  1 
ATOM   3053 C  CG1 . VAL B 2 78  ? -20.796 13.213  12.008  1    28.49  ? 248 VAL B CG1 1 
ATOM   3054 C  CG2 . VAL B 2 78  ? -22.063 11.333  13.027  1    32.5   ? 248 VAL B CG2 1 
ATOM   3055 N  N   . LEU B 2 79  ? -22.09  16.059  13.456  1    31.3   ? 249 LEU B N   1 
ATOM   3056 C  CA  . LEU B 2 79  ? -21.909 17.401  12.915  1    29.41  ? 249 LEU B CA  1 
ATOM   3057 C  C   . LEU B 2 79  ? -21.162 17.304  11.58   1    35.38  ? 249 LEU B C   1 
ATOM   3058 O  O   . LEU B 2 79  ? -20.364 16.371  11.357  1    29.41  ? 249 LEU B O   1 
ATOM   3059 C  CB  . LEU B 2 79  ? -21.131 18.233  13.932  1    27.29  ? 249 LEU B CB  1 
ATOM   3060 C  CG  . LEU B 2 79  ? -21.837 18.551  15.258  1    29.42  ? 249 LEU B CG  1 
ATOM   3061 C  CD1 . LEU B 2 79  ? -21.027 19.603  15.998  1    24.24  ? 249 LEU B CD1 1 
ATOM   3062 C  CD2 . LEU B 2 79  ? -23.266 19.03   15.051  1    25.2   ? 249 LEU B CD2 1 
ATOM   3063 N  N   . ARG B 2 80  ? -21.412 18.283  10.698  1    33.81  ? 250 ARG B N   1 
ATOM   3064 C  CA  . ARG B 2 80  ? -20.866 18.257  9.344   1    31.07  ? 250 ARG B CA  1 
ATOM   3065 C  C   . ARG B 2 80  ? -19.341 18.248  9.399   1    33.55  ? 250 ARG B C   1 
ATOM   3066 O  O   . ARG B 2 80  ? -18.72  17.629  8.539   1    32.09  ? 250 ARG B O   1 
ATOM   3067 C  CB  . ARG B 2 80  ? -21.31  19.464  8.508   1    32.96  ? 250 ARG B CB  1 
ATOM   3068 C  CG  . ARG B 2 80  ? -20.784 20.804  9.028   1    31.5   ? 250 ARG B CG  1 
ATOM   3069 C  CD  . ARG B 2 80  ? -21.409 21.963  8.332   1    29.73  ? 250 ARG B CD  1 
ATOM   3070 N  NE  . ARG B 2 80  ? -22.867 21.861  8.446   1    36.42  ? 250 ARG B NE  1 
ATOM   3071 C  CZ  . ARG B 2 80  ? -23.737 22.73   7.915   1    41.26  ? 250 ARG B CZ  1 
ATOM   3072 N  NH1 . ARG B 2 80  ? -23.345 23.788  7.228   1    39.26  ? 250 ARG B NH1 1 
ATOM   3073 N  NH2 . ARG B 2 80  ? -25.024 22.55   8.108   1    43.59  ? 250 ARG B NH2 1 
ATOM   3074 N  N   . GLY B 2 81  ? -18.761 18.908  10.428  1    29.87  ? 251 GLY B N   1 
ATOM   3075 C  CA  . GLY B 2 81  ? -17.318 18.989  10.62   1    27.33  ? 251 GLY B CA  1 
ATOM   3076 C  C   . GLY B 2 81  ? -16.66  17.648  10.958  1    27.77  ? 251 GLY B C   1 
ATOM   3077 O  O   . GLY B 2 81  ? -15.449 17.506  10.793  1    29.99  ? 251 GLY B O   1 
ATOM   3078 N  N   . LYS B 2 82  ? -17.457 16.669  11.419  1    27.13  ? 252 LYS B N   1 
ATOM   3079 C  CA  . LYS B 2 82  ? -16.953 15.358  11.791  1    25.06  ? 252 LYS B CA  1 
ATOM   3080 C  C   . LYS B 2 82  ? -17.366 14.285  10.787  1    27.42  ? 252 LYS B C   1 
ATOM   3081 O  O   . LYS B 2 82  ? -17.006 13.123  10.96   1    27.35  ? 252 LYS B O   1 
ATOM   3082 C  CB  . LYS B 2 82  ? -17.436 14.999  13.194  1    24.06  ? 252 LYS B CB  1 
ATOM   3083 C  CG  . LYS B 2 82  ? -16.875 15.85   14.334  1    24.49  ? 252 LYS B CG  1 
ATOM   3084 C  CD  . LYS B 2 82  ? -15.362 15.701  14.412  1    28.32  ? 252 LYS B CD  1 
ATOM   3085 C  CE  . LYS B 2 82  ? -14.75  16.018  15.734  1    27.15  ? 252 LYS B CE  1 
ATOM   3086 N  NZ  . LYS B 2 82  ? -14.959 17.453  15.906  1    30.28  ? 252 LYS B NZ  1 
ATOM   3087 N  N   . LEU B 2 83  ? -18.099 14.655  9.729   1    28.81  ? 253 LEU B N   1 
ATOM   3088 C  CA  . LEU B 2 83  ? -18.619 13.652  8.809   1    33.3   ? 253 LEU B CA  1 
ATOM   3089 C  C   . LEU B 2 83  ? -17.471 12.931  8.086   1    35.4   ? 253 LEU B C   1 
ATOM   3090 O  O   . LEU B 2 83  ? -17.574 11.726  7.815   1    32.29  ? 253 LEU B O   1 
ATOM   3091 C  CB  . LEU B 2 83  ? -19.6   14.245  7.787   1    35.68  ? 253 LEU B CB  1 
ATOM   3092 C  CG  . LEU B 2 83  ? -20.089 13.266  6.705   1    33.64  ? 253 LEU B CG  1 
ATOM   3093 C  CD1 . LEU B 2 83  ? -20.782 12.028  7.304   1    25.42  ? 253 LEU B CD1 1 
ATOM   3094 C  CD2 . LEU B 2 83  ? -21.041 13.935  5.752   1    33.48  ? 253 LEU B CD2 1 
ATOM   3095 N  N   . GLN B 2 84  ? -16.416 13.688  7.735   1    31.01  ? 254 GLN B N   1 
ATOM   3096 C  CA  . GLN B 2 84  ? -15.262 13.135  7.031   1    35.92  ? 254 GLN B CA  1 
ATOM   3097 C  C   . GLN B 2 84  ? -14.456 12.193  7.942   1    33.47  ? 254 GLN B C   1 
ATOM   3098 O  O   . GLN B 2 84  ? -13.887 11.204  7.479   1    30.57  ? 254 GLN B O   1 
ATOM   3099 C  CB  . GLN B 2 84  ? -14.366 14.226  6.431   1    37.22  ? 254 GLN B CB  1 
ATOM   3100 C  CG  . GLN B 2 84  ? -13.357 13.687  5.419   1    34.59  ? 254 GLN B CG  1 
ATOM   3101 C  CD  . GLN B 2 84  ? -12.394 14.715  4.849   1    39.64  ? 254 GLN B CD  1 
ATOM   3102 O  OE1 . GLN B 2 84  ? -11.741 14.456  3.829   1    46.76  ? 254 GLN B OE1 1 
ATOM   3103 N  NE2 . GLN B 2 84  ? -12.276 15.883  5.473   1    32.58  ? 254 GLN B NE2 1 
ATOM   3104 N  N   . LEU B 2 85  ? -14.422 12.483  9.249   1    28.39  ? 255 LEU B N   1 
ATOM   3105 C  CA  . LEU B 2 85  ? -13.669 11.635  10.149  1    27.42  ? 255 LEU B CA  1 
ATOM   3106 C  C   . LEU B 2 85  ? -14.31  10.263  10.189  1    29.33  ? 255 LEU B C   1 
ATOM   3107 O  O   . LEU B 2 85  ? -13.595 9.264   10.207  1    31.55  ? 255 LEU B O   1 
ATOM   3108 C  CB  . LEU B 2 85  ? -13.642 12.262  11.539  1    27.76  ? 255 LEU B CB  1 
ATOM   3109 C  CG  . LEU B 2 85  ? -13.017 11.42   12.658  1    26.29  ? 255 LEU B CG  1 
ATOM   3110 C  CD1 . LEU B 2 85  ? -11.608 10.948  12.296  1    22.23  ? 255 LEU B CD1 1 
ATOM   3111 C  CD2 . LEU B 2 85  ? -13.027 12.3    13.918  1    25.49  ? 255 LEU B CD2 1 
ATOM   3112 N  N   . VAL B 2 86  ? -15.652 10.243  10.218  1    30.33  ? 256 VAL B N   1 
ATOM   3113 C  CA  . VAL B 2 86  ? -16.428 9.01    10.208  1    28.78  ? 256 VAL B CA  1 
ATOM   3114 C  C   . VAL B 2 86  ? -16.081 8.221   8.951   1    27.19  ? 256 VAL B C   1 
ATOM   3115 O  O   . VAL B 2 86  ? -15.647 7.084   9.061   1    26.66  ? 256 VAL B O   1 
ATOM   3116 C  CB  . VAL B 2 86  ? -17.944 9.254   10.288  1    29.57  ? 256 VAL B CB  1 
ATOM   3117 C  CG1 . VAL B 2 86  ? -18.713 7.947   10.156  1    27.13  ? 256 VAL B CG1 1 
ATOM   3118 C  CG2 . VAL B 2 86  ? -18.326 9.993   11.561  1    25.02  ? 256 VAL B CG2 1 
ATOM   3119 N  N   . GLY B 2 87  ? -16.223 8.854   7.776   1    26.43  ? 257 GLY B N   1 
ATOM   3120 C  CA  . GLY B 2 87  ? -15.889 8.224   6.505   1    29.04  ? 257 GLY B CA  1 
ATOM   3121 C  C   . GLY B 2 87  ? -14.449 7.698   6.454   1    30.97  ? 257 GLY B C   1 
ATOM   3122 O  O   . GLY B 2 87  ? -14.182 6.631   5.904   1    29     ? 257 GLY B O   1 
ATOM   3123 N  N   . THR B 2 88  ? -13.519 8.449   7.046   1    32.63  ? 258 THR B N   1 
ATOM   3124 C  CA  . THR B 2 88  ? -12.114 8.063   7.045   1    33.83  ? 258 THR B CA  1 
ATOM   3125 C  C   . THR B 2 88  ? -11.976 6.775   7.836   1    31.78  ? 258 THR B C   1 
ATOM   3126 O  O   . THR B 2 88  ? -11.316 5.868   7.367   1    33.65  ? 258 THR B O   1 
ATOM   3127 C  CB  . THR B 2 88  ? -11.2   9.155   7.615   1    34.96  ? 258 THR B CB  1 
ATOM   3128 O  OG1 . THR B 2 88  ? -11.25  10.276  6.734   1    34.48  ? 258 THR B OG1 1 
ATOM   3129 C  CG2 . THR B 2 88  ? -9.759  8.695   7.727   1    35.24  ? 258 THR B CG2 1 
ATOM   3130 N  N   . ALA B 2 89  ? -12.593 6.695   9.022   1    31.02  ? 259 ALA B N   1 
ATOM   3131 C  CA  . ALA B 2 89  ? -12.443 5.484   9.831   1    34.35  ? 259 ALA B CA  1 
ATOM   3132 C  C   . ALA B 2 89  ? -13.174 4.308   9.176   1    30.64  ? 259 ALA B C   1 
ATOM   3133 O  O   . ALA B 2 89  ? -12.769 3.162   9.308   1    30.04  ? 259 ALA B O   1 
ATOM   3134 C  CB  . ALA B 2 89  ? -12.888 5.696   11.257  1    30.39  ? 259 ALA B CB  1 
ATOM   3135 N  N   . ALA B 2 90  ? -14.254 4.61    8.46    1    29.97  ? 260 ALA B N   1 
ATOM   3136 C  CA  . ALA B 2 90  ? -14.958 3.57    7.749   1    31.37  ? 260 ALA B CA  1 
ATOM   3137 C  C   . ALA B 2 90  ? -14.003 2.97    6.718   1    34.35  ? 260 ALA B C   1 
ATOM   3138 O  O   . ALA B 2 90  ? -13.916 1.744   6.601   1    34.41  ? 260 ALA B O   1 
ATOM   3139 C  CB  . ALA B 2 90  ? -16.192 4.158   7.098   1    33.21  ? 260 ALA B CB  1 
ATOM   3140 N  N   . MET B 2 91  ? -13.268 3.835   5.993   1    28.16  ? 261 MET B N   1 
ATOM   3141 C  CA  . MET B 2 91  ? -12.425 3.392   4.881   1    30.23  ? 261 MET B CA  1 
ATOM   3142 C  C   . MET B 2 91  ? -11.222 2.599   5.408   1    29.84  ? 261 MET B C   1 
ATOM   3143 O  O   . MET B 2 91  ? -10.811 1.619   4.801   1    31.11  ? 261 MET B O   1 
ATOM   3144 C  CB  . MET B 2 91  ? -11.956 4.588   4.029   1    33.17  ? 261 MET B CB  1 
ATOM   3145 C  CG  . MET B 2 91  ? -11.426 4.261   2.652   1    36.38  ? 261 MET B CG  1 
ATOM   3146 S  SD  . MET B 2 91  ? -12.712 3.508   1.638   1    44.74  ? 261 MET B SD  1 
ATOM   3147 C  CE  . MET B 2 91  ? -12.001 3.564   -0.005  1    43.11  ? 261 MET B CE  1 
ATOM   3148 N  N   . LEU B 2 92  ? -10.694 3.006   6.569   1    27.06  ? 262 LEU B N   1 
ATOM   3149 C  CA  . LEU B 2 92  ? -9.643  2.268   7.236   1    27     ? 262 LEU B CA  1 
ATOM   3150 C  C   . LEU B 2 92  ? -10.121 0.869   7.653   1    32.52  ? 262 LEU B C   1 
ATOM   3151 O  O   . LEU B 2 92  ? -9.388  -0.101  7.444   1    32.35  ? 262 LEU B O   1 
ATOM   3152 C  CB  . LEU B 2 92  ? -9.252  3.13    8.438   1    29.83  ? 262 LEU B CB  1 
ATOM   3153 C  CG  . LEU B 2 92  ? -8.234  2.54    9.43    1    28.93  ? 262 LEU B CG  1 
ATOM   3154 C  CD1 . LEU B 2 92  ? -6.901  2.231   8.77    1    29.59  ? 262 LEU B CD1 1 
ATOM   3155 C  CD2 . LEU B 2 92  ? -8.056  3.516   10.555  1    25.23  ? 262 LEU B CD2 1 
ATOM   3156 N  N   . LEU B 2 93  ? -11.328 0.769   8.244   1    25.58  ? 263 LEU B N   1 
ATOM   3157 C  CA  . LEU B 2 93  ? -11.846 -0.501  8.711   1    30.77  ? 263 LEU B CA  1 
ATOM   3158 C  C   . LEU B 2 93  ? -12.071 -1.449  7.532   1    32.86  ? 263 LEU B C   1 
ATOM   3159 O  O   . LEU B 2 93  ? -11.67  -2.609  7.576   1    35.08  ? 263 LEU B O   1 
ATOM   3160 C  CB  . LEU B 2 93  ? -13.133 -0.291  9.517   1    30.23  ? 263 LEU B CB  1 
ATOM   3161 C  CG  . LEU B 2 93  ? -12.958 0.101   10.983  1    34.25  ? 263 LEU B CG  1 
ATOM   3162 C  CD1 . LEU B 2 93  ? -14.28  0.494   11.596  1    35.96  ? 263 LEU B CD1 1 
ATOM   3163 C  CD2 . LEU B 2 93  ? -12.371 -1.059  11.786  1    38.7   ? 263 LEU B CD2 1 
ATOM   3164 N  N   . ALA B 2 94  ? -12.688 -0.946  6.475   1    33.66  ? 264 ALA B N   1 
ATOM   3165 C  CA  . ALA B 2 94  ? -12.974 -1.783  5.297   1    28.38  ? 264 ALA B CA  1 
ATOM   3166 C  C   . ALA B 2 94  ? -11.67  -2.252  4.67    1    30.77  ? 264 ALA B C   1 
ATOM   3167 O  O   . ALA B 2 94  ? -11.612 -3.381  4.185   1    39.09  ? 264 ALA B O   1 
ATOM   3168 C  CB  . ALA B 2 94  ? -13.762 -0.966  4.334   1    29.05  ? 264 ALA B CB  1 
ATOM   3169 N  N   . SER B 2 95  ? -10.656 -1.398  4.687   1    26.2   ? 265 SER B N   1 
ATOM   3170 C  CA  . SER B 2 95  ? -9.359  -1.735  4.061   1    25.91  ? 265 SER B CA  1 
ATOM   3171 C  C   . SER B 2 95  ? -8.651  -2.821  4.881   1    30.67  ? 265 SER B C   1 
ATOM   3172 O  O   . SER B 2 95  ? -8.103  -3.744  4.287   1    36.07  ? 265 SER B O   1 
ATOM   3173 C  CB  . SER B 2 95  ? -8.529  -0.502  3.908   1    25.95  ? 265 SER B CB  1 
ATOM   3174 O  OG  . SER B 2 95  ? -9.208  0.497   3.164   1    26.67  ? 265 SER B OG  1 
ATOM   3175 N  N   . LYS B 2 96  ? -8.708  -2.734  6.202   1    30.56  ? 266 LYS B N   1 
ATOM   3176 C  CA  . LYS B 2 96  ? -8.096  -3.773  7.062   1    31.95  ? 266 LYS B CA  1 
ATOM   3177 C  C   . LYS B 2 96  ? -8.846  -5.104  6.889   1    33.77  ? 266 LYS B C   1 
ATOM   3178 O  O   . LYS B 2 96  ? -8.215  -6.155  7.047   1    34.45  ? 266 LYS B O   1 
ATOM   3179 C  CB  . LYS B 2 96  ? -8.106  -3.299  8.516   1    29.21  ? 266 LYS B CB  1 
ATOM   3180 C  CG  . LYS B 2 96  ? -7.128  -2.203  8.877   1    28.1   ? 266 LYS B CG  1 
ATOM   3181 C  CD  . LYS B 2 96  ? -7.477  -1.558  10.21   1    25.6   ? 266 LYS B CD  1 
ATOM   3182 C  CE  . LYS B 2 96  ? -6.264  -1.066  10.917  1    28.04  ? 266 LYS B CE  1 
ATOM   3183 N  NZ  . LYS B 2 96  ? -6.552  -0.736  12.312  1    29.63  ? 266 LYS B NZ  1 
ATOM   3184 N  N   . PHE B 2 97  ? -10.135 -5.055  6.563   1    28.2   ? 267 PHE B N   1 
ATOM   3185 C  CA  . PHE B 2 97  ? -10.942 -6.289  6.408   1    28.97  ? 267 PHE B CA  1 
ATOM   3186 C  C   . PHE B 2 97  ? -10.752 -6.888  5.043   1    31.37  ? 267 PHE B C   1 
ATOM   3187 O  O   . PHE B 2 97  ? -10.62  -8.113  4.948   1    34.25  ? 267 PHE B O   1 
ATOM   3188 C  CB  . PHE B 2 97  ? -12.42  -5.932  6.538   1    28.25  ? 267 PHE B CB  1 
ATOM   3189 C  CG  . PHE B 2 97  ? -13.408 -7.086  6.446   1    30.6   ? 267 PHE B CG  1 
ATOM   3190 C  CD1 . PHE B 2 97  ? -13.725 -7.842  7.566   1    31.04  ? 267 PHE B CD1 1 
ATOM   3191 C  CD2 . PHE B 2 97  ? -14.031 -7.399  5.245   1    34.41  ? 267 PHE B CD2 1 
ATOM   3192 C  CE1 . PHE B 2 97  ? -14.627 -8.886  7.48    1    37.34  ? 267 PHE B CE1 1 
ATOM   3193 C  CE2 . PHE B 2 97  ? -14.929 -8.447  5.166   1    31.21  ? 267 PHE B CE2 1 
ATOM   3194 C  CZ  . PHE B 2 97  ? -15.225 -9.186  6.283   1    35.67  ? 267 PHE B CZ  1 
ATOM   3195 N  N   . GLU B 2 98  ? -10.698 -6.057  4.011   1    26.28  ? 268 GLU B N   1 
ATOM   3196 C  CA  . GLU B 2 98  ? -10.696 -6.597  2.634   1    28.11  ? 268 GLU B CA  1 
ATOM   3197 C  C   . GLU B 2 98  ? -9.367  -6.44   1.885   1    29.41  ? 268 GLU B C   1 
ATOM   3198 O  O   . GLU B 2 98  ? -9.2    -7.15   0.885   1    31.61  ? 268 GLU B O   1 
ATOM   3199 C  CB  . GLU B 2 98  ? -11.807 -5.818  1.934   1    25.92  ? 268 GLU B CB  1 
ATOM   3200 C  CG  . GLU B 2 98  ? -12.254 -6.399  0.6     1    29.31  ? 268 GLU B CG  1 
ATOM   3201 C  CD  . GLU B 2 98  ? -12.985 -7.71   0.771   1    35.43  ? 268 GLU B CD  1 
ATOM   3202 O  OE1 . GLU B 2 98  ? -13.761 -7.845  1.732   1    38.26  ? 268 GLU B OE1 1 
ATOM   3203 O  OE2 . GLU B 2 98  ? -12.769 -8.594  -0.069  1    39.07  ? 268 GLU B OE2 1 
ATOM   3204 N  N   . GLU B 2 99  ? -8.449  -5.585  2.34    1    26.45  ? 269 GLU B N   1 
ATOM   3205 C  CA  . GLU B 2 99  ? -7.245  -5.368  1.49    1    28.94  ? 269 GLU B CA  1 
ATOM   3206 C  C   . GLU B 2 99  ? -6.041  -6.223  1.901   1    34.33  ? 269 GLU B C   1 
ATOM   3207 O  O   . GLU B 2 99  ? -5.683  -6.199  3.096   1    32     ? 269 GLU B O   1 
ATOM   3208 C  CB  . GLU B 2 99  ? -6.812  -3.902  1.52    1    26.73  ? 269 GLU B CB  1 
ATOM   3209 C  CG  . GLU B 2 99  ? -7.848  -2.955  0.922   1    32.79  ? 269 GLU B CG  1 
ATOM   3210 C  CD  . GLU B 2 99  ? -7.894  -2.98   -0.594  1    32.55  ? 269 GLU B CD  1 
ATOM   3211 O  OE1 . GLU B 2 99  ? -6.823  -3.097  -1.225  1    35.85  ? 269 GLU B OE1 1 
ATOM   3212 O  OE2 . GLU B 2 99  ? -9.008  -2.876  -1.14   1    35.28  ? 269 GLU B OE2 1 
ATOM   3213 N  N   . ILE B 2 100 ? -5.461  -6.969  0.954   1    33.96  ? 270 ILE B N   1 
ATOM   3214 C  CA  . ILE B 2 100 ? -4.213  -7.68   1.198   1    29.48  ? 270 ILE B CA  1 
ATOM   3215 C  C   . ILE B 2 100 ? -3.248  -6.696  1.836   1    30.58  ? 270 ILE B C   1 
ATOM   3216 O  O   . ILE B 2 100 ? -2.628  -7.02   2.839   1    33.6   ? 270 ILE B O   1 
ATOM   3217 C  CB  . ILE B 2 100 ? -3.646  -8.26   -0.114  1    28.89  ? 270 ILE B CB  1 
ATOM   3218 C  CG1 . ILE B 2 100 ? -4.604  -9.252  -0.778  1    26.53  ? 270 ILE B CG1 1 
ATOM   3219 C  CG2 . ILE B 2 100 ? -2.254  -8.864  0.041   1    20.96  ? 270 ILE B CG2 1 
ATOM   3220 C  CD1 . ILE B 2 100 ? -4.101  -9.793  -2.107  1    25.93  ? 270 ILE B CD1 1 
ATOM   3221 N  N   . TYR B 2 101 ? -3.158  -5.494  1.25    1    35.05  ? 271 TYR B N   1 
ATOM   3222 C  CA  . TYR B 2 101 ? -2.229  -4.45   1.684   1    38.7   ? 271 TYR B CA  1 
ATOM   3223 C  C   . TYR B 2 101 ? -2.965  -3.138  1.989   1    37.33  ? 271 TYR B C   1 
ATOM   3224 O  O   . TYR B 2 101 ? -2.948  -2.198  1.194   1    40.74  ? 271 TYR B O   1 
ATOM   3225 C  CB  . TYR B 2 101 ? -1.128  -4.253  0.63    1    36.24  ? 271 TYR B CB  1 
ATOM   3226 C  CG  . TYR B 2 101 ? -0.229  -5.461  0.414   1    35.65  ? 271 TYR B CG  1 
ATOM   3227 C  CD1 . TYR B 2 101 ? 0.587   -5.92   1.45    1    36.59  ? 271 TYR B CD1 1 
ATOM   3228 C  CD2 . TYR B 2 101 ? -0.191  -6.131  -0.814  1    37.63  ? 271 TYR B CD2 1 
ATOM   3229 C  CE1 . TYR B 2 101 ? 1.411   -7.022  1.285   1    40.72  ? 271 TYR B CE1 1 
ATOM   3230 C  CE2 . TYR B 2 101 ? 0.638   -7.228  -0.995  1    39.77  ? 271 TYR B CE2 1 
ATOM   3231 C  CZ  . TYR B 2 101 ? 1.434   -7.669  0.058   1    45.17  ? 271 TYR B CZ  1 
ATOM   3232 O  OH  . TYR B 2 101 ? 2.264   -8.747  -0.073  1    63.37  ? 271 TYR B OH  1 
ATOM   3233 N  N   . PRO B 2 102 ? -3.622  -2.998  3.162   1    35.94  ? 272 PRO B N   1 
ATOM   3234 C  CA  . PRO B 2 102 ? -4.313  -1.755  3.494   1    33.65  ? 272 PRO B CA  1 
ATOM   3235 C  C   . PRO B 2 102 ? -3.315  -0.607  3.577   1    34.63  ? 272 PRO B C   1 
ATOM   3236 O  O   . PRO B 2 102 ? -2.156  -0.8    3.917   1    37.82  ? 272 PRO B O   1 
ATOM   3237 C  CB  . PRO B 2 102 ? -4.953  -2.023  4.854   1    31.94  ? 272 PRO B CB  1 
ATOM   3238 C  CG  . PRO B 2 102 ? -4.126  -3.143  5.432   1    32.63  ? 272 PRO B CG  1 
ATOM   3239 C  CD  . PRO B 2 102 ? -3.694  -3.993  4.244   1    35.08  ? 272 PRO B CD  1 
ATOM   3240 N  N   . PRO B 2 103 ? -3.727  0.629   3.238   1    37.13  ? 273 PRO B N   1 
ATOM   3241 C  CA  . PRO B 2 103 ? -2.931  1.809   3.591   1    39.46  ? 273 PRO B CA  1 
ATOM   3242 C  C   . PRO B 2 103 ? -2.71   1.932   5.105   1    42.04  ? 273 PRO B C   1 
ATOM   3243 O  O   . PRO B 2 103 ? -3.531  1.535   5.933   1    41.15  ? 273 PRO B O   1 
ATOM   3244 C  CB  . PRO B 2 103 ? -3.746  2.991   3.027   1    37.23  ? 273 PRO B CB  1 
ATOM   3245 C  CG  . PRO B 2 103 ? -4.756  2.383   2.084   1    36.67  ? 273 PRO B CG  1 
ATOM   3246 C  CD  . PRO B 2 103 ? -4.931  0.927   2.438   1    32     ? 273 PRO B CD  1 
ATOM   3247 N  N   . GLU B 2 104 ? -1.576  2.512   5.478   1    40.93  ? 274 GLU B N   1 
ATOM   3248 C  CA  . GLU B 2 104 ? -1.296  2.738   6.885   1    46.26  ? 274 GLU B CA  1 
ATOM   3249 C  C   . GLU B 2 104 ? -2.19   3.866   7.41    1    45.66  ? 274 GLU B C   1 
ATOM   3250 O  O   . GLU B 2 104 ? -2.651  4.736   6.661   1    44.03  ? 274 GLU B O   1 
ATOM   3251 C  CB  . GLU B 2 104 ? 0.189   3.087   7.057   1    50.99  ? 274 GLU B CB  1 
ATOM   3252 C  CG  . GLU B 2 104 ? 1.147   2.087   6.423   1    57.73  ? 274 GLU B CG  1 
ATOM   3253 C  CD  . GLU B 2 104 ? 2.589   2.563   6.388   1    77.52  ? 274 GLU B CD  1 
ATOM   3254 O  OE1 . GLU B 2 104 ? 3.399   1.797   6.931   1    90.49  ? 274 GLU B OE1 1 
ATOM   3255 O  OE2 . GLU B 2 104 ? 2.924   3.655   5.864   1    83.81  ? 274 GLU B OE2 1 
ATOM   3256 N  N   . VAL B 2 105 ? -2.418  3.856   8.726   1    39.51  ? 275 VAL B N   1 
ATOM   3257 C  CA  . VAL B 2 105 ? -3.227  4.886   9.348   1    38.53  ? 275 VAL B CA  1 
ATOM   3258 C  C   . VAL B 2 105 ? -2.697  6.264   8.955   1    36.72  ? 275 VAL B C   1 
ATOM   3259 O  O   . VAL B 2 105 ? -3.475  7.17    8.725   1    41.26  ? 275 VAL B O   1 
ATOM   3260 C  CB  . VAL B 2 105 ? -3.243  4.707   10.874  1    39.31  ? 275 VAL B CB  1 
ATOM   3261 C  CG1 . VAL B 2 105 ? -3.863  5.899   11.594  1    38.33  ? 275 VAL B CG1 1 
ATOM   3262 C  CG2 . VAL B 2 105 ? -3.958  3.419   11.24   1    46.05  ? 275 VAL B CG2 1 
ATOM   3263 N  N   . ALA B 2 106 ? -1.378  6.423   8.892   1    34.42  ? 276 ALA B N   1 
ATOM   3264 C  CA  . ALA B 2 106 ? -0.8    7.727   8.635   1    35.33  ? 276 ALA B CA  1 
ATOM   3265 C  C   . ALA B 2 106 ? -1.271  8.231   7.272   1    35.77  ? 276 ALA B C   1 
ATOM   3266 O  O   . ALA B 2 106 ? -1.421  9.428   7.074   1    41.84  ? 276 ALA B O   1 
ATOM   3267 C  CB  . ALA B 2 106 ? 0.71    7.701   8.802   1    29.16  ? 276 ALA B CB  1 
ATOM   3268 N  N   . GLU B 2 107 ? -1.556  7.307   6.351   1    35.46  ? 277 GLU B N   1 
ATOM   3269 C  CA  . GLU B 2 107 ? -2.015  7.698   5.037   1    37.02  ? 277 GLU B CA  1 
ATOM   3270 C  C   . GLU B 2 107 ? -3.479  8.126   5.072   1    37.71  ? 277 GLU B C   1 
ATOM   3271 O  O   . GLU B 2 107 ? -3.881  9.013   4.324   1    40.61  ? 277 GLU B O   1 
ATOM   3272 C  CB  . GLU B 2 107 ? -1.733  6.559   4.069   1    42.46  ? 277 GLU B CB  1 
ATOM   3273 C  CG  . GLU B 2 107 ? -0.231  6.341   3.954   1    49.41  ? 277 GLU B CG  1 
ATOM   3274 C  CD  . GLU B 2 107 ? 0.159   5.345   2.896   1    68.89  ? 277 GLU B CD  1 
ATOM   3275 O  OE1 . GLU B 2 107 ? 0.73    5.9     1.927   1    76.02  ? 277 GLU B OE1 1 
ATOM   3276 O  OE2 . GLU B 2 107 ? -0.08   4.099   3.041   1    66.22  ? 277 GLU B OE2 1 
ATOM   3277 N  N   . PHE B 2 108 ? -4.278  7.501   5.935   1    35.19  ? 278 PHE B N   1 
ATOM   3278 C  CA  . PHE B 2 108 ? -5.647  7.959   6.108   1    34.57  ? 278 PHE B CA  1 
ATOM   3279 C  C   . PHE B 2 108 ? -5.674  9.378   6.698   1    40.72  ? 278 PHE B C   1 
ATOM   3280 O  O   . PHE B 2 108 ? -6.495  10.187  6.29    1    41.94  ? 278 PHE B O   1 
ATOM   3281 C  CB  . PHE B 2 108 ? -6.43   6.898   6.868   1    32.5   ? 278 PHE B CB  1 
ATOM   3282 C  CG  . PHE B 2 108 ? -6.847  5.742   5.971   1    38     ? 278 PHE B CG  1 
ATOM   3283 C  CD1 . PHE B 2 108 ? -7.883  5.884   5.06    1    36.78  ? 278 PHE B CD1 1 
ATOM   3284 C  CD2 . PHE B 2 108 ? -6.204  4.505   6.038   1    37.46  ? 278 PHE B CD2 1 
ATOM   3285 C  CE1 . PHE B 2 108 ? -8.252  4.818   4.254   1    36.19  ? 278 PHE B CE1 1 
ATOM   3286 C  CE2 . PHE B 2 108 ? -6.587  3.445   5.229   1    33.17  ? 278 PHE B CE2 1 
ATOM   3287 C  CZ  . PHE B 2 108 ? -7.618  3.596   4.351   1    34.31  ? 278 PHE B CZ  1 
ATOM   3288 N  N   . VAL B 2 109 ? -4.755  9.7     7.623   1    32.81  ? 279 VAL B N   1 
ATOM   3289 C  CA  . VAL B 2 109 ? -4.653  11.033  8.166   1    33.11  ? 279 VAL B CA  1 
ATOM   3290 C  C   . VAL B 2 109 ? -4.287  11.997  7.039   1    37.45  ? 279 VAL B C   1 
ATOM   3291 O  O   . VAL B 2 109 ? -4.823  13.103  6.954   1    39.95  ? 279 VAL B O   1 
ATOM   3292 C  CB  . VAL B 2 109 ? -3.592  11.05   9.288   1    36.42  ? 279 VAL B CB  1 
ATOM   3293 C  CG1 . VAL B 2 109 ? -3.174  12.469  9.706   1    26.05  ? 279 VAL B CG1 1 
ATOM   3294 C  CG2 . VAL B 2 109 ? -4.033  10.218  10.492  1    34.95  ? 279 VAL B CG2 1 
ATOM   3295 N  N   . TYR B 2 110 ? -3.359  11.566  6.182   1    36.85  ? 280 TYR B N   1 
ATOM   3296 C  CA  . TYR B 2 110 ? -2.814  12.421  5.151   1    37.91  ? 280 TYR B CA  1 
ATOM   3297 C  C   . TYR B 2 110 ? -3.909  12.857  4.174   1    41.66  ? 280 TYR B C   1 
ATOM   3298 O  O   . TYR B 2 110 ? -3.888  13.99   3.699   1    44.3   ? 280 TYR B O   1 
ATOM   3299 C  CB  . TYR B 2 110 ? -1.64   11.737  4.45    1    45.81  ? 280 TYR B CB  1 
ATOM   3300 C  CG  . TYR B 2 110 ? -1.057  12.546  3.292   1    62.48  ? 280 TYR B CG  1 
ATOM   3301 C  CD1 . TYR B 2 110 ? -0.152  13.586  3.53    1    59.15  ? 280 TYR B CD1 1 
ATOM   3302 C  CD2 . TYR B 2 110 ? -1.43   12.292  1.964   1    60.02  ? 280 TYR B CD2 1 
ATOM   3303 C  CE1 . TYR B 2 110 ? 0.377   14.327  2.483   1    57.87  ? 280 TYR B CE1 1 
ATOM   3304 C  CE2 . TYR B 2 110 ? -0.902  13.023  0.91    1    57.94  ? 280 TYR B CE2 1 
ATOM   3305 C  CZ  . TYR B 2 110 ? 0.005   14.046  1.17    1    63.96  ? 280 TYR B CZ  1 
ATOM   3306 O  OH  . TYR B 2 110 ? 0.52    14.785  0.127   1    57.24  ? 280 TYR B OH  1 
ATOM   3307 N  N   . ILE B 2 111 ? -4.863  11.972  3.859   1    43.04  ? 281 ILE B N   1 
ATOM   3308 C  CA  . ILE B 2 111 ? -5.831  12.268  2.808   1    44.03  ? 281 ILE B CA  1 
ATOM   3309 C  C   . ILE B 2 111 ? -6.914  13.227  3.297   1    47.33  ? 281 ILE B C   1 
ATOM   3310 O  O   . ILE B 2 111 ? -7.686  13.737  2.474   1    45.62  ? 281 ILE B O   1 
ATOM   3311 C  CB  . ILE B 2 111 ? -6.455  10.99   2.233   1    46.71  ? 281 ILE B CB  1 
ATOM   3312 C  CG1 . ILE B 2 111 ? -6.991  10.103  3.344   1    46.66  ? 281 ILE B CG1 1 
ATOM   3313 C  CG2 . ILE B 2 111 ? -5.447  10.269  1.349   1    45.71  ? 281 ILE B CG2 1 
ATOM   3314 C  CD1 . ILE B 2 111 ? -8.146  9.206   2.936   1    57.37  ? 281 ILE B CD1 1 
ATOM   3315 N  N   . THR B 2 112 ? -6.969  13.441  4.626   1    44.33  ? 282 THR B N   1 
ATOM   3316 C  CA  . THR B 2 112 ? -7.898  14.373  5.251   1    41.8   ? 282 THR B CA  1 
ATOM   3317 C  C   . THR B 2 112 ? -7.304  15.774  5.375   1    44.27  ? 282 THR B C   1 
ATOM   3318 O  O   . THR B 2 112 ? -7.892  16.594  6.083   1    42.32  ? 282 THR B O   1 
ATOM   3319 C  CB  . THR B 2 112 ? -8.316  13.9    6.642   1    40.65  ? 282 THR B CB  1 
ATOM   3320 O  OG1 . THR B 2 112 ? -7.152  13.975  7.454   1    43.22  ? 282 THR B OG1 1 
ATOM   3321 C  CG2 . THR B 2 112 ? -8.931  12.517  6.673   1    33.28  ? 282 THR B CG2 1 
ATOM   3322 N  N   . ASP B 2 113 ? -6.131  16.024  4.764   1    50.88  ? 283 ASP B N   1 
ATOM   3323 C  CA  . ASP B 2 113 ? -5.452  17.319  4.787   1    59.69  ? 283 ASP B CA  1 
ATOM   3324 C  C   . ASP B 2 113 ? -5.21   17.821  6.207   1    62.7   ? 283 ASP B C   1 
ATOM   3325 O  O   . ASP B 2 113 ? -5.387  19.011  6.488   1    52.32  ? 283 ASP B O   1 
ATOM   3326 C  CB  . ASP B 2 113 ? -6.215  18.38   4.012   1    68.73  ? 283 ASP B CB  1 
ATOM   3327 C  CG  . ASP B 2 113 ? -6.189  18.184  2.51    1    77.16  ? 283 ASP B CG  1 
ATOM   3328 O  OD1 . ASP B 2 113 ? -5.343  17.386  2.034   1    70.96  ? 283 ASP B OD1 1 
ATOM   3329 O  OD2 . ASP B 2 113 ? -7.034  18.844  1.858   1    81.94  ? 283 ASP B OD2 1 
ATOM   3330 N  N   . ASP B 2 114 ? -4.851  16.889  7.104   1    73.51  ? 284 ASP B N   1 
ATOM   3331 C  CA  . ASP B 2 114 ? -4.553  17.206  8.495   1    73.39  ? 284 ASP B CA  1 
ATOM   3332 C  C   . ASP B 2 114 ? -5.689  18.025  9.118   1    57.72  ? 284 ASP B C   1 
ATOM   3333 O  O   . ASP B 2 114 ? -5.452  18.867  9.984   1    42.49  ? 284 ASP B O   1 
ATOM   3334 C  CB  . ASP B 2 114 ? -3.171  17.836  8.622   1    83.72  ? 284 ASP B CB  1 
ATOM   3335 C  CG  . ASP B 2 114 ? -1.994  17.001  8.129   1    85.25  ? 284 ASP B CG  1 
ATOM   3336 O  OD1 . ASP B 2 114 ? -2.183  15.799  7.827   1    80.38  ? 284 ASP B OD1 1 
ATOM   3337 O  OD2 . ASP B 2 114 ? -0.889  17.571  8.038   1    87.41  ? 284 ASP B OD2 1 
ATOM   3338 N  N   . THR B 2 115 ? -6.925  17.753  8.667   1    55.26  ? 285 THR B N   1 
ATOM   3339 C  CA  . THR B 2 115 ? -8.132  18.169  9.368   1    51     ? 285 THR B CA  1 
ATOM   3340 C  C   . THR B 2 115 ? -8.184  17.435  10.711  1    46.89  ? 285 THR B C   1 
ATOM   3341 O  O   . THR B 2 115 ? -8.493  18.016  11.751  1    55.22  ? 285 THR B O   1 
ATOM   3342 C  CB  . THR B 2 115 ? -9.369  17.87   8.516   1    51.08  ? 285 THR B CB  1 
ATOM   3343 O  OG1 . THR B 2 115 ? -9.261  18.564  7.283   1    47.04  ? 285 THR B OG1 1 
ATOM   3344 C  CG2 . THR B 2 115 ? -10.663 18.308  9.18    1    55.75  ? 285 THR B CG2 1 
ATOM   3345 N  N   . TYR B 2 116 ? -7.853  16.143  10.668  1    39.74  ? 286 TYR B N   1 
ATOM   3346 C  CA  . TYR B 2 116 ? -7.916  15.303  11.846  1    35.34  ? 286 TYR B CA  1 
ATOM   3347 C  C   . TYR B 2 116 ? -6.54   14.756  12.181  1    33.91  ? 286 TYR B C   1 
ATOM   3348 O  O   . TYR B 2 116 ? -5.604  14.842  11.391  1    42.07  ? 286 TYR B O   1 
ATOM   3349 C  CB  . TYR B 2 116 ? -8.856  14.135  11.58   1    29.75  ? 286 TYR B CB  1 
ATOM   3350 C  CG  . TYR B 2 116 ? -10.201 14.566  11.022  1    32.73  ? 286 TYR B CG  1 
ATOM   3351 C  CD1 . TYR B 2 116 ? -11.071 15.351  11.784  1    29.46  ? 286 TYR B CD1 1 
ATOM   3352 C  CD2 . TYR B 2 116 ? -10.611 14.153  9.754   1    32.08  ? 286 TYR B CD2 1 
ATOM   3353 C  CE1 . TYR B 2 116 ? -12.318 15.71   11.309  1    28.82  ? 286 TYR B CE1 1 
ATOM   3354 C  CE2 . TYR B 2 116 ? -11.862 14.517  9.27    1    34.6   ? 286 TYR B CE2 1 
ATOM   3355 C  CZ  . TYR B 2 116 ? -12.72  15.291  10.051  1    33.63  ? 286 TYR B CZ  1 
ATOM   3356 O  OH  . TYR B 2 116 ? -13.963 15.655  9.59    1    33.88  ? 286 TYR B OH  1 
ATOM   3357 N  N   . THR B 2 117 ? -6.442  14.221  13.391  1    33.92  ? 287 THR B N   1 
ATOM   3358 C  CA  . THR B 2 117 ? -5.181  13.749  13.926  1    36.78  ? 287 THR B CA  1 
ATOM   3359 C  C   . THR B 2 117 ? -5.204  12.235  13.858  1    39.36  ? 287 THR B C   1 
ATOM   3360 O  O   . THR B 2 117 ? -6.28   11.635  13.788  1    40.27  ? 287 THR B O   1 
ATOM   3361 C  CB  . THR B 2 117 ? -4.958  14.204  15.374  1    35.81  ? 287 THR B CB  1 
ATOM   3362 O  OG1 . THR B 2 117 ? -5.988  13.694  16.22   1    33.2   ? 287 THR B OG1 1 
ATOM   3363 C  CG2 . THR B 2 117 ? -4.843  15.71   15.497  1    28.53  ? 287 THR B CG2 1 
ATOM   3364 N  N   . LYS B 2 118 ? -4.004  11.646  13.932  1    40.32  ? 288 LYS B N   1 
ATOM   3365 C  CA  . LYS B 2 118 ? -3.883  10.203  14.044  1    38.75  ? 288 LYS B CA  1 
ATOM   3366 C  C   . LYS B 2 118 ? -4.734  9.721   15.22   1    33.47  ? 288 LYS B C   1 
ATOM   3367 O  O   . LYS B 2 118 ? -5.434  8.738   15.073  1    31.52  ? 288 LYS B O   1 
ATOM   3368 C  CB  . LYS B 2 118 ? -2.41   9.789   14.094  1    39.2   ? 288 LYS B CB  1 
ATOM   3369 C  CG  . LYS B 2 118 ? -2.157  8.302   13.947  1    38.64  ? 288 LYS B CG  1 
ATOM   3370 C  CD  . LYS B 2 118 ? -0.706  7.892   14.15   1    40.99  ? 288 LYS B CD  1 
ATOM   3371 C  CE  . LYS B 2 118 ? -0.614  6.404   13.938  1    56.53  ? 288 LYS B CE  1 
ATOM   3372 N  NZ  . LYS B 2 118 ? 0.518   5.761   14.597  1    64.9   ? 288 LYS B NZ  1 
ATOM   3373 N  N   . LYS B 2 119 ? -4.748  10.469  16.333  1    36.53  ? 289 LYS B N   1 
ATOM   3374 C  CA  . LYS B 2 119 ? -5.484  10.067  17.526  1    36.2   ? 289 LYS B CA  1 
ATOM   3375 C  C   . LYS B 2 119 ? -6.986  10.051  17.258  1    34.5   ? 289 LYS B C   1 
ATOM   3376 O  O   . LYS B 2 119 ? -7.674  9.105   17.627  1    32.29  ? 289 LYS B O   1 
ATOM   3377 C  CB  . LYS B 2 119 ? -5.191  10.995  18.702  1    39.09  ? 289 LYS B CB  1 
ATOM   3378 C  CG  . LYS B 2 119 ? -5.171  10.275  20.033  1    53.04  ? 289 LYS B CG  1 
ATOM   3379 C  CD  . LYS B 2 119 ? -4.465  11.065  21.142  1    69.77  ? 289 LYS B CD  1 
ATOM   3380 C  CE  . LYS B 2 119 ? -5.264  12.187  21.765  1    73.1   ? 289 LYS B CE  1 
ATOM   3381 N  NZ  . LYS B 2 119 ? -6.408  11.643  22.508  1    57.64  ? 289 LYS B NZ  1 
ATOM   3382 N  N   . GLN B 2 120 ? -7.483  11.082  16.567  1    34.44  ? 290 GLN B N   1 
ATOM   3383 C  CA  . GLN B 2 120 ? -8.886  11.176  16.172  1    31.99  ? 290 GLN B CA  1 
ATOM   3384 C  C   . GLN B 2 120 ? -9.348  10.02   15.273  1    33.03  ? 290 GLN B C   1 
ATOM   3385 O  O   . GLN B 2 120 ? -10.466 9.508   15.432  1    31.48  ? 290 GLN B O   1 
ATOM   3386 C  CB  . GLN B 2 120 ? -9.16   12.504  15.476  1    27.94  ? 290 GLN B CB  1 
ATOM   3387 C  CG  . GLN B 2 120 ? -9.34   13.671  16.432  1    29.36  ? 290 GLN B CG  1 
ATOM   3388 C  CD  . GLN B 2 120 ? -9.695  14.941  15.693  1    35.07  ? 290 GLN B CD  1 
ATOM   3389 O  OE1 . GLN B 2 120 ? -8.955  15.424  14.823  1    34.06  ? 290 GLN B OE1 1 
ATOM   3390 N  NE2 . GLN B 2 120 ? -10.858 15.484  16.026  1    35.16  ? 290 GLN B NE2 1 
ATOM   3391 N  N   . VAL B 2 121 ? -8.518  9.651   14.288  1    31.63  ? 291 VAL B N   1 
ATOM   3392 C  CA  . VAL B 2 121 ? -8.886  8.579   13.375  1    31.38  ? 291 VAL B CA  1 
ATOM   3393 C  C   . VAL B 2 121 ? -9.012  7.268   14.144  1    32.93  ? 291 VAL B C   1 
ATOM   3394 O  O   . VAL B 2 121 ? -9.912  6.48    13.887  1    35.55  ? 291 VAL B O   1 
ATOM   3395 C  CB  . VAL B 2 121 ? -7.861  8.435   12.238  1    28.62  ? 291 VAL B CB  1 
ATOM   3396 C  CG1 . VAL B 2 121 ? -8.119  7.186   11.404  1    22.2   ? 291 VAL B CG1 1 
ATOM   3397 C  CG2 . VAL B 2 121 ? -7.846  9.682   11.377  1    28.72  ? 291 VAL B CG2 1 
ATOM   3398 N  N   . LEU B 2 122 ? -8.069  7.02    15.047  1    29.44  ? 292 LEU B N   1 
ATOM   3399 C  CA  . LEU B 2 122 ? -8.053  5.781   15.798  1    31.76  ? 292 LEU B CA  1 
ATOM   3400 C  C   . LEU B 2 122 ? -9.203  5.733   16.799  1    33.59  ? 292 LEU B C   1 
ATOM   3401 O  O   . LEU B 2 122 ? -9.78   4.668   16.976  1    32.65  ? 292 LEU B O   1 
ATOM   3402 C  CB  . LEU B 2 122 ? -6.699  5.614   16.493  1    33.38  ? 292 LEU B CB  1 
ATOM   3403 C  CG  . LEU B 2 122 ? -5.491  5.408   15.576  1    32.1   ? 292 LEU B CG  1 
ATOM   3404 C  CD1 . LEU B 2 122 ? -4.299  4.952   16.434  1    27.68  ? 292 LEU B CD1 1 
ATOM   3405 C  CD2 . LEU B 2 122 ? -5.86   4.444   14.411  1    31.07  ? 292 LEU B CD2 1 
ATOM   3406 N  N   . ARG B 2 123 ? -9.555  6.857   17.408  1    35.85  ? 293 ARG B N   1 
ATOM   3407 C  CA  . ARG B 2 123 ? -10.626 6.828   18.431  1    35.39  ? 293 ARG B CA  1 
ATOM   3408 C  C   . ARG B 2 123 ? -11.956 6.603   17.707  1    34.81  ? 293 ARG B C   1 
ATOM   3409 O  O   . ARG B 2 123 ? -12.824 5.92    18.264  1    33.27  ? 293 ARG B O   1 
ATOM   3410 C  CB  . ARG B 2 123 ? -10.579 8.12    19.25   1    34.76  ? 293 ARG B CB  1 
ATOM   3411 C  CG  . ARG B 2 123 ? -9.4    8.23    20.204  1    38.14  ? 293 ARG B CG  1 
ATOM   3412 C  CD  . ARG B 2 123 ? -9.831  8.769   21.553  1    54.76  ? 293 ARG B CD  1 
ATOM   3413 N  NE  . ARG B 2 123 ? -11.061 8.119   22.018  1    72.61  ? 293 ARG B NE  1 
ATOM   3414 C  CZ  . ARG B 2 123 ? -11.173 7.449   23.157  1    72.43  ? 293 ARG B CZ  1 
ATOM   3415 N  NH1 . ARG B 2 123 ? -10.091 7.082   23.819  1    69.03  ? 293 ARG B NH1 1 
ATOM   3416 N  NH2 . ARG B 2 123 ? -12.368 7.15    23.63   1    66.58  ? 293 ARG B NH2 1 
ATOM   3417 N  N   . MET B 2 124 ? -12.084 7.144   16.502  1    32.16  ? 294 MET B N   1 
ATOM   3418 C  CA  . MET B 2 124 ? -13.29  6.973   15.706  1    30.52  ? 294 MET B CA  1 
ATOM   3419 C  C   . MET B 2 124 ? -13.386 5.527   15.231  1    32.18  ? 294 MET B C   1 
ATOM   3420 O  O   . MET B 2 124 ? -14.489 4.988   15.115  1    37.03  ? 294 MET B O   1 
ATOM   3421 C  CB  . MET B 2 124 ? -13.281 7.883   14.471  1    32.08  ? 294 MET B CB  1 
ATOM   3422 C  CG  . MET B 2 124 ? -14.514 7.769   13.576  1    31.5   ? 294 MET B CG  1 
ATOM   3423 S  SD  . MET B 2 124 ? -16.044 8.29    14.396  1    36.84  ? 294 MET B SD  1 
ATOM   3424 C  CE  . MET B 2 124 ? -15.874 10.073  14.588  1    25.35  ? 294 MET B CE  1 
ATOM   3425 N  N   . GLU B 2 125 ? -12.232 4.936   14.899  1    30.2   ? 295 GLU B N   1 
ATOM   3426 C  CA  . GLU B 2 125 ? -12.137 3.545   14.485  1    30.84  ? 295 GLU B CA  1 
ATOM   3427 C  C   . GLU B 2 125 ? -12.797 2.683   15.559  1    34.33  ? 295 GLU B C   1 
ATOM   3428 O  O   . GLU B 2 125 ? -13.615 1.818   15.244  1    37.4   ? 295 GLU B O   1 
ATOM   3429 C  CB  . GLU B 2 125 ? -10.69  3.105   14.226  1    26.59  ? 295 GLU B CB  1 
ATOM   3430 C  CG  . GLU B 2 125 ? -10.578 1.655   13.765  1    28.38  ? 295 GLU B CG  1 
ATOM   3431 C  CD  . GLU B 2 125 ? -9.175  1.055   13.662  1    34.34  ? 295 GLU B CD  1 
ATOM   3432 O  OE1 . GLU B 2 125 ? -8.487  0.825   14.699  1    34.18  ? 295 GLU B OE1 1 
ATOM   3433 O  OE2 . GLU B 2 125 ? -8.773  0.784   12.508  1    37.47  ? 295 GLU B OE2 1 
ATOM   3434 N  N   . HIS B 2 126 ? -12.438 2.946   16.822  1    30.99  ? 296 HIS B N   1 
ATOM   3435 C  CA  . HIS B 2 126 ? -13.004 2.229   17.95   1    36.39  ? 296 HIS B CA  1 
ATOM   3436 C  C   . HIS B 2 126 ? -14.511 2.502   18.071  1    36.02  ? 296 HIS B C   1 
ATOM   3437 O  O   . HIS B 2 126 ? -15.273 1.61    18.426  1    34.01  ? 296 HIS B O   1 
ATOM   3438 C  CB  . HIS B 2 126 ? -12.205 2.548   19.217  1    42.01  ? 296 HIS B CB  1 
ATOM   3439 C  CG  . HIS B 2 126 ? -12.113 1.378   20.111  1    60.35  ? 296 HIS B CG  1 
ATOM   3440 N  ND1 . HIS B 2 126 ? -12.758 1.309   21.327  1    77.6   ? 296 HIS B ND1 1 
ATOM   3441 C  CD2 . HIS B 2 126 ? -11.452 0.224   19.941  1    67.74  ? 296 HIS B CD2 1 
ATOM   3442 C  CE1 . HIS B 2 126 ? -12.52  0.118   21.844  1    93.07  ? 296 HIS B CE1 1 
ATOM   3443 N  NE2 . HIS B 2 126 ? -11.73  -0.561  21.022  1    90.33  ? 296 HIS B NE2 1 
ATOM   3444 N  N   . LEU B 2 127 ? -14.931 3.748   17.826  1    31.29  ? 297 LEU B N   1 
ATOM   3445 C  CA  . LEU B 2 127 ? -16.325 4.107   17.961  1    29.87  ? 297 LEU B CA  1 
ATOM   3446 C  C   . LEU B 2 127 ? -17.155 3.356   16.923  1    29.37  ? 297 LEU B C   1 
ATOM   3447 O  O   . LEU B 2 127 ? -18.185 2.789   17.246  1    28.37  ? 297 LEU B O   1 
ATOM   3448 C  CB  . LEU B 2 127 ? -16.538 5.616   17.883  1    28.69  ? 297 LEU B CB  1 
ATOM   3449 C  CG  . LEU B 2 127 ? -17.962 6.095   18.224  1    27.97  ? 297 LEU B CG  1 
ATOM   3450 C  CD1 . LEU B 2 127 ? -18.445 5.606   19.621  1    20.62  ? 297 LEU B CD1 1 
ATOM   3451 C  CD2 . LEU B 2 127 ? -18.066 7.626   18.144  1    27.59  ? 297 LEU B CD2 1 
ATOM   3452 N  N   . VAL B 2 128 ? -16.696 3.346   15.672  1    31.16  ? 298 VAL B N   1 
ATOM   3453 C  CA  . VAL B 2 128 ? -17.447 2.661   14.637  1    31.41  ? 298 VAL B CA  1 
ATOM   3454 C  C   . VAL B 2 128 ? -17.523 1.172   14.955  1    34.45  ? 298 VAL B C   1 
ATOM   3455 O  O   . VAL B 2 128 ? -18.574 0.55    14.74   1    39.68  ? 298 VAL B O   1 
ATOM   3456 C  CB  . VAL B 2 128 ? -16.89  2.92    13.228  1    29.31  ? 298 VAL B CB  1 
ATOM   3457 C  CG1 . VAL B 2 128 ? -17.448 1.929   12.219  1    27.21  ? 298 VAL B CG1 1 
ATOM   3458 C  CG2 . VAL B 2 128 ? -17.138 4.357   12.793  1    24.68  ? 298 VAL B CG2 1 
ATOM   3459 N  N   . LEU B 2 129 ? -16.416 0.616   15.474  1    30.55  ? 299 LEU B N   1 
ATOM   3460 C  CA  . LEU B 2 129 ? -16.37  -0.794  15.828  1    29.12  ? 299 LEU B CA  1 
ATOM   3461 C  C   . LEU B 2 129 ? -17.423 -1.089  16.897  1    31.04  ? 299 LEU B C   1 
ATOM   3462 O  O   . LEU B 2 129 ? -18.162 -2.068  16.782  1    34.87  ? 299 LEU B O   1 
ATOM   3463 C  CB  . LEU B 2 129 ? -14.962 -1.221  16.24   1    27.21  ? 299 LEU B CB  1 
ATOM   3464 C  CG  . LEU B 2 129 ? -13.95  -1.446  15.109  1    27.95  ? 299 LEU B CG  1 
ATOM   3465 C  CD1 . LEU B 2 129 ? -12.55  -1.698  15.644  1    22.21  ? 299 LEU B CD1 1 
ATOM   3466 C  CD2 . LEU B 2 129 ? -14.406 -2.573  14.179  1    26.8   ? 299 LEU B CD2 1 
ATOM   3467 N  N   . LYS B 2 130 ? -17.514 -0.21   17.9    1    28.83  ? 300 LYS B N   1 
ATOM   3468 C  CA  . LYS B 2 130 ? -18.476 -0.34   18.985  1    34.04  ? 300 LYS B CA  1 
ATOM   3469 C  C   . LYS B 2 130 ? -19.912 -0.2    18.439  1    40.69  ? 300 LYS B C   1 
ATOM   3470 O  O   . LYS B 2 130 ? -20.804 -0.982  18.769  1    42.11  ? 300 LYS B O   1 
ATOM   3471 C  CB  . LYS B 2 130 ? -18.124 0.641   20.111  1    35.47  ? 300 LYS B CB  1 
ATOM   3472 C  CG  . LYS B 2 130 ? -19.159 0.682   21.244  1    56.68  ? 300 LYS B CG  1 
ATOM   3473 C  CD  . LYS B 2 130 ? -19.383 1.963   22.055  1    62.56  ? 300 LYS B CD  1 
ATOM   3474 C  CE  . LYS B 2 130 ? -20.777 2.143   22.599  1    60.57  ? 300 LYS B CE  1 
ATOM   3475 N  NZ  . LYS B 2 130 ? -20.785 3.151   23.667  1    65.95  ? 300 LYS B NZ  1 
ATOM   3476 N  N   . VAL B 2 131 ? -20.156 0.801   17.588  1    31.99  ? 301 VAL B N   1 
ATOM   3477 C  CA  . VAL B 2 131 ? -21.506 1.048   17.136  1    29.81  ? 301 VAL B CA  1 
ATOM   3478 C  C   . VAL B 2 131 ? -21.964 -0.118  16.266  1    31.21  ? 301 VAL B C   1 
ATOM   3479 O  O   . VAL B 2 131 ? -23.103 -0.535  16.368  1    35.54  ? 301 VAL B O   1 
ATOM   3480 C  CB  . VAL B 2 131 ? -21.574 2.411   16.418  1    29.43  ? 301 VAL B CB  1 
ATOM   3481 C  CG1 . VAL B 2 131 ? -22.833 2.581   15.571  1    25.68  ? 301 VAL B CG1 1 
ATOM   3482 C  CG2 . VAL B 2 131 ? -21.405 3.546   17.425  1    23.09  ? 301 VAL B CG2 1 
ATOM   3483 N  N   . LEU B 2 132 ? -21.081 -0.665  15.434  1    30.37  ? 302 LEU B N   1 
ATOM   3484 C  CA  . LEU B 2 132 ? -21.455 -1.765  14.564  1    28.87  ? 302 LEU B CA  1 
ATOM   3485 C  C   . LEU B 2 132 ? -21.358 -3.114  15.295  1    33.31  ? 302 LEU B C   1 
ATOM   3486 O  O   . LEU B 2 132 ? -21.715 -4.145  14.719  1    30.58  ? 302 LEU B O   1 
ATOM   3487 C  CB  . LEU B 2 132 ? -20.532 -1.728  13.349  1    26.34  ? 302 LEU B CB  1 
ATOM   3488 C  CG  . LEU B 2 132 ? -20.591 -0.447  12.511  1    28.32  ? 302 LEU B CG  1 
ATOM   3489 C  CD1 . LEU B 2 132 ? -19.716 -0.562  11.275  1    26.21  ? 302 LEU B CD1 1 
ATOM   3490 C  CD2 . LEU B 2 132 ? -21.982 -0.032  12.099  1    22.54  ? 302 LEU B CD2 1 
ATOM   3491 N  N   . ALA B 2 133 ? -20.837 -3.109  16.547  1    30.1   ? 303 ALA B N   1 
ATOM   3492 C  CA  . ALA B 2 133 ? -20.562 -4.315  17.318  1    26.92  ? 303 ALA B CA  1 
ATOM   3493 C  C   . ALA B 2 133 ? -19.721 -5.301  16.495  1    30.35  ? 303 ALA B C   1 
ATOM   3494 O  O   . ALA B 2 133 ? -19.945 -6.51   16.556  1    27.6   ? 303 ALA B O   1 
ATOM   3495 C  CB  . ALA B 2 133 ? -21.844 -4.942  17.814  1    20.09  ? 303 ALA B CB  1 
ATOM   3496 N  N   . PHE B 2 134 ? -18.765 -4.76   15.716  1    30.45  ? 304 PHE B N   1 
ATOM   3497 C  CA  . PHE B 2 134 ? -17.853 -5.517  14.868  1    34.22  ? 304 PHE B CA  1 
ATOM   3498 C  C   . PHE B 2 134 ? -18.555 -6.309  13.749  1    38.45  ? 304 PHE B C   1 
ATOM   3499 O  O   . PHE B 2 134 ? -17.934 -7.196  13.149  1    41.62  ? 304 PHE B O   1 
ATOM   3500 C  CB  . PHE B 2 134 ? -16.989 -6.516  15.654  1    30.79  ? 304 PHE B CB  1 
ATOM   3501 C  CG  . PHE B 2 134 ? -15.915 -5.911  16.534  1    32.75  ? 304 PHE B CG  1 
ATOM   3502 C  CD1 . PHE B 2 134 ? -16.235 -5.351  17.777  1    31.8   ? 304 PHE B CD1 1 
ATOM   3503 C  CD2 . PHE B 2 134 ? -14.577 -5.932  16.125  1    32.31  ? 304 PHE B CD2 1 
ATOM   3504 C  CE1 . PHE B 2 134 ? -15.244 -4.781  18.578  1    32.09  ? 304 PHE B CE1 1 
ATOM   3505 C  CE2 . PHE B 2 134 ? -13.594 -5.362  16.926  1    30.48  ? 304 PHE B CE2 1 
ATOM   3506 C  CZ  . PHE B 2 134 ? -13.924 -4.797  18.15   1    31.3   ? 304 PHE B CZ  1 
ATOM   3507 N  N   A ASP B 2 135 ? -19.821 -5.994  13.457  0.5  35.03  ? 305 ASP B N   1 
ATOM   3508 N  N   B ASP B 2 135 ? -19.829 -6.007  13.454  0.5  37.81  ? 305 ASP B N   1 
ATOM   3509 C  CA  A ASP B 2 135 ? -20.499 -6.679  12.37   0.5  34.54  ? 305 ASP B CA  1 
ATOM   3510 C  CA  B ASP B 2 135 ? -20.509 -6.698  12.368  0.5  39.64  ? 305 ASP B CA  1 
ATOM   3511 C  C   A ASP B 2 135 ? -20.052 -6.072  11.041  0.5  33.61  ? 305 ASP B C   1 
ATOM   3512 C  C   B ASP B 2 135 ? -20.061 -6.089  11.038  0.5  36.22  ? 305 ASP B C   1 
ATOM   3513 O  O   A ASP B 2 135 ? -20.759 -5.237  10.487  0.5  37.69  ? 305 ASP B O   1 
ATOM   3514 O  O   B ASP B 2 135 ? -20.777 -5.266  10.476  0.5  40.22  ? 305 ASP B O   1 
ATOM   3515 C  CB  A ASP B 2 135 ? -22.002 -6.741  12.601  0.5  32.2   ? 305 ASP B CB  1 
ATOM   3516 C  CB  B ASP B 2 135 ? -22.022 -6.754  12.563  0.5  42.62  ? 305 ASP B CB  1 
ATOM   3517 C  CG  A ASP B 2 135 ? -22.419 -7.641  13.756  0.5  34.04  ? 305 ASP B CG  1 
ATOM   3518 C  CG  B ASP B 2 135 ? -22.762 -7.701  11.621  0.5  52.98  ? 305 ASP B CG  1 
ATOM   3519 O  OD1 A ASP B 2 135 ? -21.908 -8.788  13.856  0.5  33.16  ? 305 ASP B OD1 1 
ATOM   3520 O  OD1 B ASP B 2 135 ? -22.422 -8.914  11.595  0.5  60.09  ? 305 ASP B OD1 1 
ATOM   3521 O  OD2 A ASP B 2 135 ? -23.259 -7.192  14.541  0.5  39.31  ? 305 ASP B OD2 1 
ATOM   3522 O  OD2 B ASP B 2 135 ? -23.66  -7.232  10.902  0.5  57.69  ? 305 ASP B OD2 1 
ATOM   3523 N  N   . LEU B 2 136 ? -18.88  -6.497  10.554  1    30.53  ? 306 LEU B N   1 
ATOM   3524 C  CA  . LEU B 2 136 ? -18.213 -5.861  9.42    1    35.44  ? 306 LEU B CA  1 
ATOM   3525 C  C   . LEU B 2 136 ? -18.304 -6.681  8.132   1    38.14  ? 306 LEU B C   1 
ATOM   3526 O  O   . LEU B 2 136 ? -17.96  -6.18   7.066   1    35.97  ? 306 LEU B O   1 
ATOM   3527 C  CB  . LEU B 2 136 ? -16.745 -5.626  9.769   1    39.34  ? 306 LEU B CB  1 
ATOM   3528 C  CG  . LEU B 2 136 ? -16.451 -4.571  10.848  1    44.76  ? 306 LEU B CG  1 
ATOM   3529 C  CD1 . LEU B 2 136 ? -15.067 -4.003  10.629  1    40.45  ? 306 LEU B CD1 1 
ATOM   3530 C  CD2 . LEU B 2 136 ? -17.448 -3.427  10.836  1    34.72  ? 306 LEU B CD2 1 
ATOM   3531 N  N   . ALA B 2 137 ? -18.731 -7.951  8.231   1    38.95  ? 307 ALA B N   1 
ATOM   3532 C  CA  . ALA B 2 137 ? -18.808 -8.84   7.077   1    30.85  ? 307 ALA B CA  1 
ATOM   3533 C  C   . ALA B 2 137 ? -20.168 -8.673  6.405   1    28.78  ? 307 ALA B C   1 
ATOM   3534 O  O   . ALA B 2 137 ? -20.96  -9.598  6.308   1    27.85  ? 307 ALA B O   1 
ATOM   3535 C  CB  . ALA B 2 137 ? -18.554 -10.269 7.492   1    25.03  ? 307 ALA B CB  1 
ATOM   3536 N  N   . ALA B 2 138 ? -20.418 -7.46   5.944   1    29.66  ? 308 ALA B N   1 
ATOM   3537 C  CA  . ALA B 2 138 ? -21.705 -7.06   5.42    1    34.08  ? 308 ALA B CA  1 
ATOM   3538 C  C   . ALA B 2 138 ? -21.775 -7.363  3.925   1    36     ? 308 ALA B C   1 
ATOM   3539 O  O   . ALA B 2 138 ? -20.825 -7.1    3.186   1    30.88  ? 308 ALA B O   1 
ATOM   3540 C  CB  . ALA B 2 138 ? -21.83  -5.571  5.607   1    29.04  ? 308 ALA B CB  1 
ATOM   3541 N  N   . PRO B 2 139 ? -22.95  -7.818  3.438   1    37.82  ? 309 PRO B N   1 
ATOM   3542 C  CA  . PRO B 2 139 ? -23.172 -7.958  1.996   1    33.81  ? 309 PRO B CA  1 
ATOM   3543 C  C   . PRO B 2 139 ? -23.164 -6.594  1.335   1    32.71  ? 309 PRO B C   1 
ATOM   3544 O  O   . PRO B 2 139 ? -23.701 -5.619  1.886   1    34.15  ? 309 PRO B O   1 
ATOM   3545 C  CB  . PRO B 2 139 ? -24.566 -8.589  1.878   1    33.04  ? 309 PRO B CB  1 
ATOM   3546 C  CG  . PRO B 2 139 ? -24.9   -9.051  3.278   1    38.72  ? 309 PRO B CG  1 
ATOM   3547 C  CD  . PRO B 2 139 ? -24.136 -8.16   4.254   1    33.26  ? 309 PRO B CD  1 
ATOM   3548 N  N   . THR B 2 140 ? -22.552 -6.574  0.148   1    35.46  ? 310 THR B N   1 
ATOM   3549 C  CA  . THR B 2 140 ? -22.48  -5.408  -0.728  1    36.65  ? 310 THR B CA  1 
ATOM   3550 C  C   . THR B 2 140 ? -23.206 -5.659  -2.057  1    38.09  ? 310 THR B C   1 
ATOM   3551 O  O   . THR B 2 140 ? -23.475 -6.804  -2.461  1    35.64  ? 310 THR B O   1 
ATOM   3552 C  CB  . THR B 2 140 ? -21.009 -5.068  -0.987  1    32.97  ? 310 THR B CB  1 
ATOM   3553 O  OG1 . THR B 2 140 ? -20.39  -6.11   -1.749  1    37.24  ? 310 THR B OG1 1 
ATOM   3554 C  CG2 . THR B 2 140 ? -20.234 -4.828  0.296   1    27.03  ? 310 THR B CG2 1 
ATOM   3555 N  N   . ILE B 2 141 ? -23.488 -4.555  -2.767  1    36.11  ? 311 ILE B N   1 
ATOM   3556 C  CA  . ILE B 2 141 ? -24.02  -4.638  -4.114  1    34.74  ? 311 ILE B CA  1 
ATOM   3557 C  C   . ILE B 2 141 ? -23.067 -5.516  -4.906  1    37.47  ? 311 ILE B C   1 
ATOM   3558 O  O   . ILE B 2 141 ? -23.471 -6.31   -5.752  1    46.58  ? 311 ILE B O   1 
ATOM   3559 C  CB  . ILE B 2 141 ? -24.115 -3.237  -4.741  1    33.22  ? 311 ILE B CB  1 
ATOM   3560 C  CG1 . ILE B 2 141 ? -25.297 -2.471  -4.196  1    28.55  ? 311 ILE B CG1 1 
ATOM   3561 C  CG2 . ILE B 2 141 ? -24.141 -3.317  -6.263  1    29.83  ? 311 ILE B CG2 1 
ATOM   3562 C  CD1 . ILE B 2 141 ? -25.146 -0.967  -4.313  1    24.84  ? 311 ILE B CD1 1 
ATOM   3563 N  N   . ASN B 2 142 ? -21.792 -5.366  -4.595  1    37.65  ? 312 ASN B N   1 
ATOM   3564 C  CA  . ASN B 2 142 ? -20.744 -5.933  -5.424  1    42.7   ? 312 ASN B CA  1 
ATOM   3565 C  C   . ASN B 2 142 ? -20.711 -7.455  -5.259  1    39.92  ? 312 ASN B C   1 
ATOM   3566 O  O   . ASN B 2 142 ? -20.534 -8.195  -6.239  1    36.61  ? 312 ASN B O   1 
ATOM   3567 C  CB  . ASN B 2 142 ? -19.479 -5.161  -5.133  1    43.46  ? 312 ASN B CB  1 
ATOM   3568 C  CG  . ASN B 2 142 ? -18.274 -5.743  -5.798  1    45.66  ? 312 ASN B CG  1 
ATOM   3569 O  OD1 . ASN B 2 142 ? -18.016 -5.396  -6.963  1    48.6   ? 312 ASN B OD1 1 
ATOM   3570 N  ND2 . ASN B 2 142 ? -17.541 -6.552  -5.029  1    40.41  ? 312 ASN B ND2 1 
ATOM   3571 N  N   . GLN B 2 143 ? -20.965 -7.922  -4.027  1    36.6   ? 313 GLN B N   1 
ATOM   3572 C  CA  . GLN B 2 143 ? -20.936 -9.357  -3.769  1    37.94  ? 313 GLN B CA  1 
ATOM   3573 C  C   . GLN B 2 143 ? -22.036 -10.089 -4.543  1    39.21  ? 313 GLN B C   1 
ATOM   3574 O  O   . GLN B 2 143 ? -21.865 -11.249 -4.912  1    39.44  ? 313 GLN B O   1 
ATOM   3575 C  CB  . GLN B 2 143 ? -21.084 -9.634  -2.276  1    35.48  ? 313 GLN B CB  1 
ATOM   3576 C  CG  . GLN B 2 143 ? -19.764 -9.629  -1.515  1    32.21  ? 313 GLN B CG  1 
ATOM   3577 C  CD  . GLN B 2 143 ? -20.005 -9.662  -0.031  1    33.26  ? 313 GLN B CD  1 
ATOM   3578 O  OE1 . GLN B 2 143 ? -20.474 -10.661 0.53    1    41     ? 313 GLN B OE1 1 
ATOM   3579 N  NE2 . GLN B 2 143 ? -19.739 -8.537  0.614   1    31.99  ? 313 GLN B NE2 1 
ATOM   3580 N  N   . PHE B 2 144 ? -23.184 -9.424  -4.741  1    33.79  ? 314 PHE B N   1 
ATOM   3581 C  CA  . PHE B 2 144 ? -24.265 -10.001 -5.513  1    35.22  ? 314 PHE B CA  1 
ATOM   3582 C  C   . PHE B 2 144 ? -23.921 -9.948  -7      1    37.55  ? 314 PHE B C   1 
ATOM   3583 O  O   . PHE B 2 144 ? -24.067 -10.972 -7.688  1    38.13  ? 314 PHE B O   1 
ATOM   3584 C  CB  . PHE B 2 144 ? -25.584 -9.316  -5.226  1    30.47  ? 314 PHE B CB  1 
ATOM   3585 C  CG  . PHE B 2 144 ? -26.14  -9.712  -3.887  1    32.2   ? 314 PHE B CG  1 
ATOM   3586 C  CD1 . PHE B 2 144 ? -26.683 -10.983 -3.704  1    35.07  ? 314 PHE B CD1 1 
ATOM   3587 C  CD2 . PHE B 2 144 ? -26.129 -8.81   -2.828  1    33.46  ? 314 PHE B CD2 1 
ATOM   3588 C  CE1 . PHE B 2 144 ? -27.224 -11.339 -2.463  1    34.05  ? 314 PHE B CE1 1 
ATOM   3589 C  CE2 . PHE B 2 144 ? -26.665 -9.182  -1.578  1    31.99  ? 314 PHE B CE2 1 
ATOM   3590 C  CZ  . PHE B 2 144 ? -27.212 -10.442 -1.406  1    28.54  ? 314 PHE B CZ  1 
ATOM   3591 N  N   . LEU B 2 145 ? -23.44  -8.778  -7.456  1    30.97  ? 315 LEU B N   1 
ATOM   3592 C  CA  . LEU B 2 145 ? -23.074 -8.584  -8.85   1    35.1   ? 315 LEU B CA  1 
ATOM   3593 C  C   . LEU B 2 145 ? -22.181 -9.721  -9.368  1    37.23  ? 315 LEU B C   1 
ATOM   3594 O  O   . LEU B 2 145 ? -22.451 -10.276 -10.44  1    34.54  ? 315 LEU B O   1 
ATOM   3595 C  CB  . LEU B 2 145 ? -22.378 -7.239  -9.03   1    36.94  ? 315 LEU B CB  1 
ATOM   3596 C  CG  . LEU B 2 145 ? -23.271 -6.032  -9.301  1    34.85  ? 315 LEU B CG  1 
ATOM   3597 C  CD1 . LEU B 2 145 ? -22.374 -4.845  -9.591  1    32.23  ? 315 LEU B CD1 1 
ATOM   3598 C  CD2 . LEU B 2 145 ? -24.174 -6.258  -10.463 1    33.35  ? 315 LEU B CD2 1 
ATOM   3599 N  N   . THR B 2 146 ? -21.112 -10.055 -8.62   1    35.69  ? 316 THR B N   1 
ATOM   3600 C  CA  . THR B 2 146 ? -20.103 -10.989 -9.11   1    36.74  ? 316 THR B CA  1 
ATOM   3601 C  C   . THR B 2 146 ? -20.718 -12.366 -9.332  1    36.29  ? 316 THR B C   1 
ATOM   3602 O  O   . THR B 2 146 ? -20.285 -13.093 -10.221 1    39.81  ? 316 THR B O   1 
ATOM   3603 C  CB  . THR B 2 146 ? -18.878 -11.076 -8.2    1    35.71  ? 316 THR B CB  1 
ATOM   3604 O  OG1 . THR B 2 146 ? -19.296 -11.533 -6.916  1    35.45  ? 316 THR B OG1 1 
ATOM   3605 C  CG2 . THR B 2 146 ? -18.176 -9.745  -8.063  1    30.92  ? 316 THR B CG2 1 
ATOM   3606 N  N   . GLN B 2 147 ? -21.715 -12.726 -8.506  1    35.99  ? 317 GLN B N   1 
ATOM   3607 C  CA  . GLN B 2 147 ? -22.455 -13.968 -8.691  1    31.49  ? 317 GLN B CA  1 
ATOM   3608 C  C   . GLN B 2 147 ? -23.403 -13.885 -9.882  1    34.1   ? 317 GLN B C   1 
ATOM   3609 O  O   . GLN B 2 147 ? -23.558 -14.855 -10.612 1    39.49  ? 317 GLN B O   1 
ATOM   3610 C  CB  . GLN B 2 147 ? -23.329 -14.193 -7.474  1    30.64  ? 317 GLN B CB  1 
ATOM   3611 C  CG  . GLN B 2 147 ? -22.52  -14.526 -6.239  1    34.97  ? 317 GLN B CG  1 
ATOM   3612 C  CD  . GLN B 2 147 ? -23.411 -14.86  -5.079  1    38.62  ? 317 GLN B CD  1 
ATOM   3613 O  OE1 . GLN B 2 147 ? -23.276 -14.248 -4.027  1    50.09  ? 317 GLN B OE1 1 
ATOM   3614 N  NE2 . GLN B 2 147 ? -24.288 -15.842 -5.246  1    40.59  ? 317 GLN B NE2 1 
ATOM   3615 N  N   . TYR B 2 148 ? -24.075 -12.742 -10.045 1    31.46  ? 318 TYR B N   1 
ATOM   3616 C  CA  . TYR B 2 148 ? -24.96  -12.567 -11.184 1    34.5   ? 318 TYR B CA  1 
ATOM   3617 C  C   . TYR B 2 148 ? -24.162 -12.705 -12.485 1    33.68  ? 318 TYR B C   1 
ATOM   3618 O  O   . TYR B 2 148 ? -24.704 -13.131 -13.509 1    30.27  ? 318 TYR B O   1 
ATOM   3619 C  CB  . TYR B 2 148 ? -25.697 -11.222 -11.127 1    29.38  ? 318 TYR B CB  1 
ATOM   3620 C  CG  . TYR B 2 148 ? -26.618 -11.004 -9.935  1    30.31  ? 318 TYR B CG  1 
ATOM   3621 C  CD1 . TYR B 2 148 ? -26.995 -12.039 -9.08   1    27.17  ? 318 TYR B CD1 1 
ATOM   3622 C  CD2 . TYR B 2 148 ? -27.134 -9.738  -9.678  1    31.47  ? 318 TYR B CD2 1 
ATOM   3623 C  CE1 . TYR B 2 148 ? -27.836 -11.802 -8.002  1    27.89  ? 318 TYR B CE1 1 
ATOM   3624 C  CE2 . TYR B 2 148 ? -27.972 -9.492  -8.6    1    30.04  ? 318 TYR B CE2 1 
ATOM   3625 C  CZ  . TYR B 2 148 ? -28.314 -10.525 -7.745  1    29.92  ? 318 TYR B CZ  1 
ATOM   3626 O  OH  . TYR B 2 148 ? -29.138 -10.268 -6.683  1    30.13  ? 318 TYR B OH  1 
ATOM   3627 N  N   . PHE B 2 149 ? -22.878 -12.318 -12.451 1    33.7   ? 319 PHE B N   1 
ATOM   3628 C  CA  . PHE B 2 149 ? -22.051 -12.304 -13.649 1    33.85  ? 319 PHE B CA  1 
ATOM   3629 C  C   . PHE B 2 149 ? -21.849 -13.732 -14.152 1    36.7   ? 319 PHE B C   1 
ATOM   3630 O  O   . PHE B 2 149 ? -21.71  -13.937 -15.35  1    40.17  ? 319 PHE B O   1 
ATOM   3631 C  CB  . PHE B 2 149 ? -20.694 -11.657 -13.393 1    33.46  ? 319 PHE B CB  1 
ATOM   3632 C  CG  . PHE B 2 149 ? -20.67  -10.157 -13.161 1    36.05  ? 319 PHE B CG  1 
ATOM   3633 C  CD1 . PHE B 2 149 ? -21.788 -9.363  -13.452 1    36.46  ? 319 PHE B CD1 1 
ATOM   3634 C  CD2 . PHE B 2 149 ? -19.519 -9.557  -12.641 1    32     ? 319 PHE B CD2 1 
ATOM   3635 C  CE1 . PHE B 2 149 ? -21.766 -7.994  -13.22  1    33.42  ? 319 PHE B CE1 1 
ATOM   3636 C  CE2 . PHE B 2 149 ? -19.476 -8.185  -12.454 1    33.16  ? 319 PHE B CE2 1 
ATOM   3637 C  CZ  . PHE B 2 149 ? -20.605 -7.41   -12.737 1    40.79  ? 319 PHE B CZ  1 
ATOM   3638 N  N   . LEU B 2 150 ? -21.876 -14.721 -13.247 1    35.47  ? 320 LEU B N   1 
ATOM   3639 C  CA  . LEU B 2 150 ? -21.705 -16.106 -13.646 1    34.68  ? 320 LEU B CA  1 
ATOM   3640 C  C   . LEU B 2 150 ? -22.821 -16.576 -14.585 1    35.95  ? 320 LEU B C   1 
ATOM   3641 O  O   . LEU B 2 150 ? -22.702 -17.645 -15.175 1    44.47  ? 320 LEU B O   1 
ATOM   3642 C  CB  . LEU B 2 150 ? -21.555 -16.999 -12.421 1    31.28  ? 320 LEU B CB  1 
ATOM   3643 C  CG  . LEU B 2 150 ? -20.401 -16.619 -11.484 1    41.04  ? 320 LEU B CG  1 
ATOM   3644 C  CD1 . LEU B 2 150 ? -20.371 -17.445 -10.197 1    37.14  ? 320 LEU B CD1 1 
ATOM   3645 C  CD2 . LEU B 2 150 ? -19.034 -16.659 -12.195 1    35.4   ? 320 LEU B CD2 1 
ATOM   3646 N  N   . HIS B 2 151 ? -23.903 -15.801 -14.727 1    34.65  ? 321 HIS B N   1 
ATOM   3647 C  CA  . HIS B 2 151 ? -25.043 -16.253 -15.516 1    35.02  ? 321 HIS B CA  1 
ATOM   3648 C  C   . HIS B 2 151 ? -25.036 -15.653 -16.925 1    40.97  ? 321 HIS B C   1 
ATOM   3649 O  O   . HIS B 2 151 ? -26.048 -15.701 -17.612 1    46.83  ? 321 HIS B O   1 
ATOM   3650 C  CB  . HIS B 2 151 ? -26.352 -15.933 -14.8   1    31.86  ? 321 HIS B CB  1 
ATOM   3651 C  CG  . HIS B 2 151 ? -26.59  -16.737 -13.562 1    35.78  ? 321 HIS B CG  1 
ATOM   3652 N  ND1 . HIS B 2 151 ? -27.68  -17.583 -13.416 1    33.32  ? 321 HIS B ND1 1 
ATOM   3653 C  CD2 . HIS B 2 151 ? -25.871 -16.812 -12.41  1    28.84  ? 321 HIS B CD2 1 
ATOM   3654 C  CE1 . HIS B 2 151 ? -27.615 -18.136 -12.205 1    35.19  ? 321 HIS B CE1 1 
ATOM   3655 N  NE2 . HIS B 2 151 ? -26.517 -17.687 -11.595 1    31.73  ? 321 HIS B NE2 1 
ATOM   3656 N  N   . GLN B 2 152 ? -23.903 -15.081 -17.357 1    44.86  ? 322 GLN B N   1 
ATOM   3657 C  CA  . GLN B 2 152 ? -23.817 -14.486 -18.674 1    45.12  ? 322 GLN B CA  1 
ATOM   3658 C  C   . GLN B 2 152 ? -23.55  -15.593 -19.683 1    56.64  ? 322 GLN B C   1 
ATOM   3659 O  O   . GLN B 2 152 ? -22.758 -16.497 -19.418 1    49.45  ? 322 GLN B O   1 
ATOM   3660 C  CB  . GLN B 2 152 ? -22.671 -13.499 -18.801 1    39.75  ? 322 GLN B CB  1 
ATOM   3661 C  CG  . GLN B 2 152 ? -22.84  -12.216 -18.008 1    48.37  ? 322 GLN B CG  1 
ATOM   3662 C  CD  . GLN B 2 152 ? -21.562 -11.392 -18.016 1    63.54  ? 322 GLN B CD  1 
ATOM   3663 O  OE1 . GLN B 2 152 ? -21.466 -10.412 -18.768 1    66.42  ? 322 GLN B OE1 1 
ATOM   3664 N  NE2 . GLN B 2 152 ? -20.551 -11.804 -17.246 1    46.04  ? 322 GLN B NE2 1 
ATOM   3665 N  N   . GLN B 2 153 ? -24.187 -15.449 -20.853 1    65.69  ? 323 GLN B N   1 
ATOM   3666 C  CA  . GLN B 2 153 ? -24.118 -16.416 -21.934 1    76.33  ? 323 GLN B CA  1 
ATOM   3667 C  C   . GLN B 2 153 ? -23.643 -15.714 -23.218 1    73.48  ? 323 GLN B C   1 
ATOM   3668 O  O   . GLN B 2 153 ? -24.48  -15.266 -24.018 1    64.52  ? 323 GLN B O   1 
ATOM   3669 C  CB  . GLN B 2 153 ? -25.544 -16.981 -22.009 1    80.77  ? 323 GLN B CB  1 
ATOM   3670 C  CG  . GLN B 2 153 ? -25.702 -18.271 -22.817 1    104.56 ? 323 GLN B CG  1 
ATOM   3671 C  CD  . GLN B 2 153 ? -25.292 -19.531 -22.08  1    111.74 ? 323 GLN B CD  1 
ATOM   3672 O  OE1 . GLN B 2 153 ? -25.28  -19.6   -20.844 1    111.19 ? 323 GLN B OE1 1 
ATOM   3673 N  NE2 . GLN B 2 153 ? -24.995 -20.566 -22.854 1    103.84 ? 323 GLN B NE2 1 
ATOM   3674 N  N   . PRO B 2 154 ? -22.311 -15.537 -23.472 1    60.9   ? 324 PRO B N   1 
ATOM   3675 C  CA  . PRO B 2 154 ? -21.222 -15.84  -22.524 1    54.77  ? 324 PRO B CA  1 
ATOM   3676 C  C   . PRO B 2 154 ? -20.73  -14.575 -21.803 1    50.63  ? 324 PRO B C   1 
ATOM   3677 O  O   . PRO B 2 154 ? -21.32  -13.486 -21.942 1    44.96  ? 324 PRO B O   1 
ATOM   3678 C  CB  . PRO B 2 154 ? -20.145 -16.337 -23.515 1    48.48  ? 324 PRO B CB  1 
ATOM   3679 C  CG  . PRO B 2 154 ? -20.29  -15.373 -24.702 1    43.46  ? 324 PRO B CG  1 
ATOM   3680 C  CD  . PRO B 2 154 ? -21.774 -14.97  -24.728 1    47.63  ? 324 PRO B CD  1 
ATOM   3681 N  N   . ALA B 2 155 ? -19.609 -14.701 -21.068 1    44.12  ? 325 ALA B N   1 
ATOM   3682 C  CA  . ALA B 2 155 ? -19.127 -13.585 -20.258 1    42.55  ? 325 ALA B CA  1 
ATOM   3683 C  C   . ALA B 2 155 ? -18.76  -12.408 -21.156 1    46.21  ? 325 ALA B C   1 
ATOM   3684 O  O   . ALA B 2 155 ? -18.226 -12.605 -22.241 1    55     ? 325 ALA B O   1 
ATOM   3685 C  CB  . ALA B 2 155 ? -17.962 -14.001 -19.432 1    35.75  ? 325 ALA B CB  1 
ATOM   3686 N  N   . ASN B 2 156 ? -19.123 -11.199 -20.725 1    38.04  ? 326 ASN B N   1 
ATOM   3687 C  CA  . ASN B 2 156 ? -18.821 -9.987  -21.454 1    33.47  ? 326 ASN B CA  1 
ATOM   3688 C  C   . ASN B 2 156 ? -18.283 -9.003  -20.429 1    38.9   ? 326 ASN B C   1 
ATOM   3689 O  O   . ASN B 2 156 ? -18.962 -8.745  -19.424 1    48.23  ? 326 ASN B O   1 
ATOM   3690 C  CB  . ASN B 2 156 ? -20.055 -9.47   -22.185 1    32.73  ? 326 ASN B CB  1 
ATOM   3691 C  CG  . ASN B 2 156 ? -19.766 -8.253  -23.034 1    40.66  ? 326 ASN B CG  1 
ATOM   3692 O  OD1 . ASN B 2 156 ? -19.217 -7.26   -22.538 1    53.33  ? 326 ASN B OD1 1 
ATOM   3693 N  ND2 . ASN B 2 156 ? -20.11  -8.29   -24.313 1    36.9   ? 326 ASN B ND2 1 
ATOM   3694 N  N   A CYS B 2 157 ? -17.076 -8.473  -20.676 0.5  38.58  ? 327 CYS B N   1 
ATOM   3695 N  N   B CYS B 2 157 ? -17.08  -8.467  -20.696 0.5  37.93  ? 327 CYS B N   1 
ATOM   3696 C  CA  A CYS B 2 157 ? -16.381 -7.63   -19.711 0.5  37.22  ? 327 CYS B CA  1 
ATOM   3697 C  CA  B CYS B 2 157 ? -16.352 -7.626  -19.752 0.5  36.21  ? 327 CYS B CA  1 
ATOM   3698 C  C   A CYS B 2 157 ? -16.977 -6.222  -19.694 0.5  34.48  ? 327 CYS B C   1 
ATOM   3699 C  C   B CYS B 2 157 ? -16.946 -6.221  -19.711 0.5  33.96  ? 327 CYS B C   1 
ATOM   3700 O  O   A CYS B 2 157 ? -16.973 -5.574  -18.649 0.5  32.77  ? 327 CYS B O   1 
ATOM   3701 O  O   B CYS B 2 157 ? -16.916 -5.584  -18.661 0.5  32.53  ? 327 CYS B O   1 
ATOM   3702 C  CB  A CYS B 2 157 ? -14.875 -7.623  -19.95  0.5  40.51  ? 327 CYS B CB  1 
ATOM   3703 C  CB  B CYS B 2 157 ? -14.849 -7.594  -20.023 0.5  38.47  ? 327 CYS B CB  1 
ATOM   3704 S  SG  A CYS B 2 157 ? -14.106 -9.26   -19.815 0.5  44.56  ? 327 CYS B SG  1 
ATOM   3705 S  SG  B CYS B 2 157 ? -14.398 -6.984  -21.668 0.5  40.51  ? 327 CYS B SG  1 
ATOM   3706 N  N   . LYS B 2 158 ? -17.494 -5.763  -20.844 1    32.38  ? 328 LYS B N   1 
ATOM   3707 C  CA  . LYS B 2 158 ? -18.192 -4.483  -20.909 1    30.58  ? 328 LYS B CA  1 
ATOM   3708 C  C   . LYS B 2 158 ? -19.461 -4.563  -20.059 1    33.15  ? 328 LYS B C   1 
ATOM   3709 O  O   . LYS B 2 158 ? -19.806 -3.609  -19.376 1    32.15  ? 328 LYS B O   1 
ATOM   3710 C  CB  . LYS B 2 158 ? -18.504 -4.065  -22.348 1    32.27  ? 328 LYS B CB  1 
ATOM   3711 C  CG  . LYS B 2 158 ? -17.468 -3.188  -23.016 1    36.69  ? 328 LYS B CG  1 
ATOM   3712 C  CD  . LYS B 2 158 ? -17.218 -3.609  -24.454 1    50.52  ? 328 LYS B CD  1 
ATOM   3713 C  CE  . LYS B 2 158 ? -18.387 -3.628  -25.401 1    54.99  ? 328 LYS B CE  1 
ATOM   3714 N  NZ  . LYS B 2 158 ? -18.768 -2.282  -25.856 1    60.51  ? 328 LYS B NZ  1 
ATOM   3715 N  N   . VAL B 2 159 ? -20.129 -5.725  -20.056 1    32.71  ? 329 VAL B N   1 
ATOM   3716 C  CA  . VAL B 2 159 ? -21.334 -5.895  -19.262 1    32.13  ? 329 VAL B CA  1 
ATOM   3717 C  C   . VAL B 2 159 ? -20.963 -5.789  -17.789 1    31.62  ? 329 VAL B C   1 
ATOM   3718 O  O   . VAL B 2 159 ? -21.601 -5.062  -17.033 1    33.44  ? 329 VAL B O   1 
ATOM   3719 C  CB  . VAL B 2 159 ? -22.069 -7.207  -19.592 1    29.36  ? 329 VAL B CB  1 
ATOM   3720 C  CG1 . VAL B 2 159 ? -23.141 -7.539  -18.561 1    29.01  ? 329 VAL B CG1 1 
ATOM   3721 C  CG2 . VAL B 2 159 ? -22.652 -7.171  -20.995 1    27.62  ? 329 VAL B CG2 1 
ATOM   3722 N  N   . GLU B 2 160 ? -19.908 -6.502  -17.404 1    33.31  ? 330 GLU B N   1 
ATOM   3723 C  CA  . GLU B 2 160 ? -19.492 -6.546  -16.01  1    34.26  ? 330 GLU B CA  1 
ATOM   3724 C  C   . GLU B 2 160 ? -19.126 -5.148  -15.542 1    33.5   ? 330 GLU B C   1 
ATOM   3725 O  O   . GLU B 2 160 ? -19.627 -4.717  -14.513 1    39.66  ? 330 GLU B O   1 
ATOM   3726 C  CB  . GLU B 2 160 ? -18.322 -7.503  -15.803 1    34.87  ? 330 GLU B CB  1 
ATOM   3727 C  CG  . GLU B 2 160 ? -18.721 -8.937  -16.13  1    36.77  ? 330 GLU B CG  1 
ATOM   3728 C  CD  . GLU B 2 160 ? -17.676 -9.987  -15.837 1    38.3   ? 330 GLU B CD  1 
ATOM   3729 O  OE1 . GLU B 2 160 ? -16.73  -9.683  -15.052 1    37.75  ? 330 GLU B OE1 1 
ATOM   3730 O  OE2 . GLU B 2 160 ? -17.818 -11.097 -16.41  1    41.1   ? 330 GLU B OE2 1 
ATOM   3731 N  N   . SER B 2 161 ? -18.291 -4.446  -16.313 1    32.14  ? 331 SER B N   1 
ATOM   3732 C  CA  . SER B 2 161 ? -17.784 -3.154  -15.879 1    31.27  ? 331 SER B CA  1 
ATOM   3733 C  C   . SER B 2 161 ? -18.937 -2.159  -15.798 1    33.32  ? 331 SER B C   1 
ATOM   3734 O  O   . SER B 2 161 ? -18.988 -1.393  -14.841 1    30.62  ? 331 SER B O   1 
ATOM   3735 C  CB  . SER B 2 161 ? -16.631 -2.648  -16.744 1    30.14  ? 331 SER B CB  1 
ATOM   3736 O  OG  . SER B 2 161 ? -15.451 -3.417  -16.54  1    31.01  ? 331 SER B OG  1 
ATOM   3737 N  N   . LEU B 2 162 ? -19.863 -2.188  -16.781 1    28.72  ? 332 LEU B N   1 
ATOM   3738 C  CA  . LEU B 2 162 ? -20.973 -1.255  -16.765 1    27.19  ? 332 LEU B CA  1 
ATOM   3739 C  C   . LEU B 2 162 ? -21.858 -1.502  -15.543 1    31.28  ? 332 LEU B C   1 
ATOM   3740 O  O   . LEU B 2 162 ? -22.365 -0.549  -14.953 1    32.55  ? 332 LEU B O   1 
ATOM   3741 C  CB  . LEU B 2 162 ? -21.79  -1.323  -18.042 1    24.73  ? 332 LEU B CB  1 
ATOM   3742 C  CG  . LEU B 2 162 ? -22.824 -0.215  -18.22  1    23.3   ? 332 LEU B CG  1 
ATOM   3743 C  CD1 . LEU B 2 162 ? -22.165 1.159   -18.095 1    23.42  ? 332 LEU B CD1 1 
ATOM   3744 C  CD2 . LEU B 2 162 ? -23.561 -0.303  -19.548 1    23.77  ? 332 LEU B CD2 1 
ATOM   3745 N  N   . ALA B 2 163 ? -22.019 -2.75   -15.125 1    29.49  ? 333 ALA B N   1 
ATOM   3746 C  CA  . ALA B 2 163 ? -22.854 -3.058  -13.942 1    29.66  ? 333 ALA B CA  1 
ATOM   3747 C  C   . ALA B 2 163 ? -22.229 -2.476  -12.676 1    31.56  ? 333 ALA B C   1 
ATOM   3748 O  O   . ALA B 2 163 ? -22.952 -1.915  -11.846 1    30.58  ? 333 ALA B O   1 
ATOM   3749 C  CB  . ALA B 2 163 ? -23.028 -4.541  -13.822 1    27.85  ? 333 ALA B CB  1 
ATOM   3750 N  N   . MET B 2 164 ? -20.914 -2.591  -12.55  1    29.32  ? 334 MET B N   1 
ATOM   3751 C  CA  . MET B 2 164 ? -20.212 -2.107  -11.337 1    34.33  ? 334 MET B CA  1 
ATOM   3752 C  C   . MET B 2 164 ? -20.287 -0.58   -11.263 1    33.06  ? 334 MET B C   1 
ATOM   3753 O  O   . MET B 2 164 ? -20.447 -0.065  -10.153 1    30.6   ? 334 MET B O   1 
ATOM   3754 C  CB  . MET B 2 164 ? -18.759 -2.587  -11.353 1    38.2   ? 334 MET B CB  1 
ATOM   3755 C  CG  . MET B 2 164 ? -18.586 -4.002  -10.852 1    50.29  ? 334 MET B CG  1 
ATOM   3756 S  SD  . MET B 2 164 ? -16.976 -4.679  -11.292 1    68.13  ? 334 MET B SD  1 
ATOM   3757 C  CE  . MET B 2 164 ? -16.365 -3.384  -12.377 1    58.06  ? 334 MET B CE  1 
ATOM   3758 N  N   . PHE B 2 165 ? -20.19  0.1     -12.402 1    29.14  ? 335 PHE B N   1 
ATOM   3759 C  CA  . PHE B 2 165 ? -20.288 1.579   -12.449 1    28.04  ? 335 PHE B CA  1 
ATOM   3760 C  C   . PHE B 2 165 ? -21.648 2.01    -11.971 1    32.35  ? 335 PHE B C   1 
ATOM   3761 O  O   . PHE B 2 165 ? -21.739 2.908   -11.133 1    38.58  ? 335 PHE B O   1 
ATOM   3762 C  CB  . PHE B 2 165 ? -20.049 1.95    -13.911 1    29.6   ? 335 PHE B CB  1 
ATOM   3763 C  CG  . PHE B 2 165 ? -20.437 3.352   -14.351 1    27.15  ? 335 PHE B CG  1 
ATOM   3764 C  CD1 . PHE B 2 165 ? -19.745 4.461   -13.886 1    24.03  ? 335 PHE B CD1 1 
ATOM   3765 C  CD2 . PHE B 2 165 ? -21.475 3.552   -15.25  1    30.78  ? 335 PHE B CD2 1 
ATOM   3766 C  CE1 . PHE B 2 165 ? -20.095 5.734   -14.297 1    26.88  ? 335 PHE B CE1 1 
ATOM   3767 C  CE2 . PHE B 2 165 ? -21.82  4.827   -15.659 1    29.67  ? 335 PHE B CE2 1 
ATOM   3768 C  CZ  . PHE B 2 165 ? -21.129 5.913   -15.183 1    30.69  ? 335 PHE B CZ  1 
ATOM   3769 N  N   . LEU B 2 166 ? -22.69  1.391   -12.511 1    33.29  ? 336 LEU B N   1 
ATOM   3770 C  CA  . LEU B 2 166 ? -24.073 1.782   -12.162 1    33.42  ? 336 LEU B CA  1 
ATOM   3771 C  C   . LEU B 2 166 ? -24.303 1.487   -10.681 1    34.53  ? 336 LEU B C   1 
ATOM   3772 O  O   . LEU B 2 166 ? -24.759 2.388   -9.969  1    35.12  ? 336 LEU B O   1 
ATOM   3773 C  CB  . LEU B 2 166 ? -25.024 1.021   -13.079 1    29.84  ? 336 LEU B CB  1 
ATOM   3774 C  CG  . LEU B 2 166 ? -24.948 1.384   -14.563 1    27.41  ? 336 LEU B CG  1 
ATOM   3775 C  CD1 . LEU B 2 166 ? -25.831 0.477   -15.394 1    28.88  ? 336 LEU B CD1 1 
ATOM   3776 C  CD2 . LEU B 2 166 ? -25.317 2.836   -14.76  1    25.04  ? 336 LEU B CD2 1 
ATOM   3777 N  N   . GLY B 2 167 ? -23.996 0.272   -10.242 1    31.78  ? 337 GLY B N   1 
ATOM   3778 C  CA  . GLY B 2 167 ? -24.087 -0.02   -8.823  1    29.26  ? 337 GLY B CA  1 
ATOM   3779 C  C   . GLY B 2 167 ? -23.319 1.017   -8.011  1    32.59  ? 337 GLY B C   1 
ATOM   3780 O  O   . GLY B 2 167 ? -23.797 1.461   -6.964  1    34.06  ? 337 GLY B O   1 
ATOM   3781 N  N   . GLU B 2 168 ? -22.152 1.443   -8.52   1    32.11  ? 338 GLU B N   1 
ATOM   3782 C  CA  . GLU B 2 168 ? -21.339 2.41    -7.78   1    36.13  ? 338 GLU B CA  1 
ATOM   3783 C  C   . GLU B 2 168 ? -22.065 3.759   -7.739  1    39.11  ? 338 GLU B C   1 
ATOM   3784 O  O   . GLU B 2 168 ? -22.113 4.42    -6.69   1    41.05  ? 338 GLU B O   1 
ATOM   3785 C  CB  . GLU B 2 168 ? -19.943 2.517   -8.392  1    30.52  ? 338 GLU B CB  1 
ATOM   3786 C  CG  . GLU B 2 168 ? -18.853 2.676   -7.351  1    32.31  ? 338 GLU B CG  1 
ATOM   3787 C  CD  . GLU B 2 168 ? -17.439 2.519   -7.863  1    34.16  ? 338 GLU B CD  1 
ATOM   3788 O  OE1 . GLU B 2 168 ? -16.745 3.555   -7.915  1    35.6   ? 338 GLU B OE1 1 
ATOM   3789 O  OE2 . GLU B 2 168 ? -17.035 1.384   -8.168  1    29.75  ? 338 GLU B OE2 1 
ATOM   3790 N  N   . LEU B 2 169 ? -22.673 4.137   -8.877  1    33.29  ? 339 LEU B N   1 
ATOM   3791 C  CA  . LEU B 2 169 ? -23.387 5.398   -8.967  1    34.21  ? 339 LEU B CA  1 
ATOM   3792 C  C   . LEU B 2 169 ? -24.466 5.459   -7.889  1    33.04  ? 339 LEU B C   1 
ATOM   3793 O  O   . LEU B 2 169 ? -24.749 6.525   -7.369  1    35.32  ? 339 LEU B O   1 
ATOM   3794 C  CB  . LEU B 2 169 ? -23.969 5.558   -10.368 1    30.06  ? 339 LEU B CB  1 
ATOM   3795 C  CG  . LEU B 2 169 ? -23.004 6.101   -11.429 1    35.03  ? 339 LEU B CG  1 
ATOM   3796 C  CD1 . LEU B 2 169 ? -23.719 6.277   -12.767 1    30.61  ? 339 LEU B CD1 1 
ATOM   3797 C  CD2 . LEU B 2 169 ? -22.371 7.427   -11.009 1    34.32  ? 339 LEU B CD2 1 
ATOM   3798 N  N   . SER B 2 170 ? -25.082 4.315   -7.588  1    29.85  ? 340 SER B N   1 
ATOM   3799 C  CA  . SER B 2 170 ? -26.18  4.262   -6.638  1    38.15  ? 340 SER B CA  1 
ATOM   3800 C  C   . SER B 2 170 ? -25.698 4.654   -5.23   1    39.14  ? 340 SER B C   1 
ATOM   3801 O  O   . SER B 2 170 ? -26.47  5.245   -4.482  1    43.45  ? 340 SER B O   1 
ATOM   3802 C  CB  . SER B 2 170 ? -26.867 2.889   -6.64   1    34.96  ? 340 SER B CB  1 
ATOM   3803 O  OG  . SER B 2 170 ? -26.171 1.986   -5.78   1    34.45  ? 340 SER B OG  1 
ATOM   3804 N  N   . LEU B 2 171 ? -24.437 4.33    -4.879  1    34.94  ? 341 LEU B N   1 
ATOM   3805 C  CA  . LEU B 2 171 ? -23.882 4.568   -3.56   1    32.56  ? 341 LEU B CA  1 
ATOM   3806 C  C   . LEU B 2 171 ? -23.867 6.057   -3.212  1    36.17  ? 341 LEU B C   1 
ATOM   3807 O  O   . LEU B 2 171 ? -23.823 6.41    -2.029  1    32.69  ? 341 LEU B O   1 
ATOM   3808 C  CB  . LEU B 2 171 ? -22.473 4.002   -3.501  1    33.14  ? 341 LEU B CB  1 
ATOM   3809 C  CG  . LEU B 2 171 ? -22.359 2.483   -3.6    1    36.69  ? 341 LEU B CG  1 
ATOM   3810 C  CD1 . LEU B 2 171 ? -20.88  2.102   -3.522  1    37     ? 341 LEU B CD1 1 
ATOM   3811 C  CD2 . LEU B 2 171 ? -23.105 1.803   -2.49   1    38.87  ? 341 LEU B CD2 1 
ATOM   3812 N  N   . ILE B 2 172 ? -23.888 6.914   -4.247  1    34.51  ? 342 ILE B N   1 
ATOM   3813 C  CA  . ILE B 2 172 ? -23.767 8.349   -4.067  1    31.49  ? 342 ILE B CA  1 
ATOM   3814 C  C   . ILE B 2 172 ? -25.06  8.945   -3.483  1    38.8   ? 342 ILE B C   1 
ATOM   3815 O  O   . ILE B 2 172 ? -25.012 9.931   -2.732  1    42.52  ? 342 ILE B O   1 
ATOM   3816 C  CB  . ILE B 2 172 ? -23.399 9.016   -5.396  1    26.95  ? 342 ILE B CB  1 
ATOM   3817 C  CG1 . ILE B 2 172 ? -22.099 8.493   -5.982  1    28.38  ? 342 ILE B CG1 1 
ATOM   3818 C  CG2 . ILE B 2 172 ? -23.321 10.527  -5.213  1    29.14  ? 342 ILE B CG2 1 
ATOM   3819 C  CD1 . ILE B 2 172 ? -20.86  9.049   -5.314  1    27.47  ? 342 ILE B CD1 1 
ATOM   3820 N  N   . ASP B 2 173 ? -26.213 8.374   -3.865  1    33.15  ? 343 ASP B N   1 
ATOM   3821 C  CA  . ASP B 2 173 ? -27.485 9.055   -3.724  1    32.37  ? 343 ASP B CA  1 
ATOM   3822 C  C   . ASP B 2 173 ? -28.355 8.277   -2.745  1    36.79  ? 343 ASP B C   1 
ATOM   3823 O  O   . ASP B 2 173 ? -29.14  7.436   -3.166  1    40.92  ? 343 ASP B O   1 
ATOM   3824 C  CB  . ASP B 2 173 ? -28.156 9.237   -5.073  1    29.52  ? 343 ASP B CB  1 
ATOM   3825 C  CG  . ASP B 2 173 ? -27.381 10.132  -6.031  1    34.91  ? 343 ASP B CG  1 
ATOM   3826 O  OD1 . ASP B 2 173 ? -26.974 11.213  -5.579  1    31.64  ? 343 ASP B OD1 1 
ATOM   3827 O  OD2 . ASP B 2 173 ? -27.185 9.737   -7.223  1    34.11  ? 343 ASP B OD2 1 
ATOM   3828 N  N   . ALA B 2 174 ? -28.245 8.587   -1.447  1    36.54  ? 344 ALA B N   1 
ATOM   3829 C  CA  . ALA B 2 174 ? -28.989 7.843   -0.45   1    34.79  ? 344 ALA B CA  1 
ATOM   3830 C  C   . ALA B 2 174 ? -30.478 7.941   -0.77   1    35.96  ? 344 ALA B C   1 
ATOM   3831 O  O   . ALA B 2 174 ? -31.235 7.025   -0.47   1    35.97  ? 344 ALA B O   1 
ATOM   3832 C  CB  . ALA B 2 174 ? -28.67  8.343   0.933   1    35.86  ? 344 ALA B CB  1 
ATOM   3833 N  N   . ASP B 2 175 ? -30.885 9.054   -1.377  1    31.12  ? 345 ASP B N   1 
ATOM   3834 C  CA  . ASP B 2 175 ? -32.233 9.16    -1.911  1    34.94  ? 345 ASP B CA  1 
ATOM   3835 C  C   . ASP B 2 175 ? -32.147 9.043   -3.434  1    34.99  ? 345 ASP B C   1 
ATOM   3836 O  O   . ASP B 2 175 ? -31.671 9.968   -4.087  1    36.17  ? 345 ASP B O   1 
ATOM   3837 C  CB  . ASP B 2 175 ? -32.932 10.448  -1.454  1    33.7   ? 345 ASP B CB  1 
ATOM   3838 C  CG  . ASP B 2 175 ? -34.297 10.723  -2.087  1    32.2   ? 345 ASP B CG  1 
ATOM   3839 O  OD1 . ASP B 2 175 ? -34.789 9.835   -2.794  1    35.5   ? 345 ASP B OD1 1 
ATOM   3840 O  OD2 . ASP B 2 175 ? -34.885 11.818  -1.876  1    31.65  ? 345 ASP B OD2 1 
ATOM   3841 N  N   . PRO B 2 176 ? -32.71  7.993   -4.08   1    37.62  ? 346 PRO B N   1 
ATOM   3842 C  CA  . PRO B 2 176 ? -33.573 7.001   -3.418  1    36.22  ? 346 PRO B CA  1 
ATOM   3843 C  C   . PRO B 2 176 ? -32.95  5.713   -2.871  1    34.21  ? 346 PRO B C   1 
ATOM   3844 O  O   . PRO B 2 176 ? -33.596 4.972   -2.132  1    37.35  ? 346 PRO B O   1 
ATOM   3845 C  CB  . PRO B 2 176 ? -34.489 6.679   -4.617  1    31.7   ? 346 PRO B CB  1 
ATOM   3846 C  CG  . PRO B 2 176 ? -33.522 6.612   -5.787  1    33.02  ? 346 PRO B CG  1 
ATOM   3847 C  CD  . PRO B 2 176 ? -32.581 7.767   -5.537  1    32.35  ? 346 PRO B CD  1 
ATOM   3848 N  N   . TYR B 2 177 ? -31.698 5.452   -3.225  1    32.39  ? 347 TYR B N   1 
ATOM   3849 C  CA  . TYR B 2 177 ? -31.184 4.09    -3.234  1    34.11  ? 347 TYR B CA  1 
ATOM   3850 C  C   . TYR B 2 177 ? -31.206 3.415   -1.86   1    35.27  ? 347 TYR B C   1 
ATOM   3851 O  O   . TYR B 2 177 ? -31.212 2.189   -1.797  1    37.12  ? 347 TYR B O   1 
ATOM   3852 C  CB  . TYR B 2 177 ? -29.85  4.025   -3.985  1    28.85  ? 347 TYR B CB  1 
ATOM   3853 C  CG  . TYR B 2 177 ? -30.087 4.293   -5.46   1    31.42  ? 347 TYR B CG  1 
ATOM   3854 C  CD1 . TYR B 2 177 ? -30.776 3.381   -6.256  1    28.74  ? 347 TYR B CD1 1 
ATOM   3855 C  CD2 . TYR B 2 177 ? -29.682 5.496   -6.021  1    34.35  ? 347 TYR B CD2 1 
ATOM   3856 C  CE1 . TYR B 2 177 ? -31.036 3.656   -7.585  1    31.07  ? 347 TYR B CE1 1 
ATOM   3857 C  CE2 . TYR B 2 177 ? -29.932 5.781   -7.345  1    33.85  ? 347 TYR B CE2 1 
ATOM   3858 C  CZ  . TYR B 2 177 ? -30.608 4.86    -8.12   1    33.39  ? 347 TYR B CZ  1 
ATOM   3859 O  OH  . TYR B 2 177 ? -30.825 5.208   -9.417  1    36.57  ? 347 TYR B OH  1 
ATOM   3860 N  N   . LEU B 2 178 ? -31.248 4.182   -0.768  1    36.68  ? 348 LEU B N   1 
ATOM   3861 C  CA  . LEU B 2 178 ? -31.313 3.586   0.561   1    39.18  ? 348 LEU B CA  1 
ATOM   3862 C  C   . LEU B 2 178 ? -32.54  2.698   0.721   1    38.22  ? 348 LEU B C   1 
ATOM   3863 O  O   . LEU B 2 178 ? -32.585 1.924   1.659   1    44.18  ? 348 LEU B O   1 
ATOM   3864 C  CB  . LEU B 2 178 ? -31.297 4.618   1.687   1    39.08  ? 348 LEU B CB  1 
ATOM   3865 C  CG  . LEU B 2 178 ? -29.914 5.045   2.184   1    43.67  ? 348 LEU B CG  1 
ATOM   3866 C  CD1 . LEU B 2 178 ? -30.067 5.87    3.456   1    38.34  ? 348 LEU B CD1 1 
ATOM   3867 C  CD2 . LEU B 2 178 ? -29.017 3.829   2.406   1    39.56  ? 348 LEU B CD2 1 
ATOM   3868 N  N   . LYS B 2 179 ? -33.549 2.851   -0.141  1    39.67  ? 349 LYS B N   1 
ATOM   3869 C  CA  . LYS B 2 179 ? -34.789 2.109   0.034   1    41.19  ? 349 LYS B CA  1 
ATOM   3870 C  C   . LYS B 2 179 ? -34.724 0.736   -0.636  1    38.23  ? 349 LYS B C   1 
ATOM   3871 O  O   . LYS B 2 179 ? -35.674 -0.032  -0.517  1    43.49  ? 349 LYS B O   1 
ATOM   3872 C  CB  . LYS B 2 179 ? -35.987 2.908   -0.493  1    41.78  ? 349 LYS B CB  1 
ATOM   3873 C  CG  . LYS B 2 179 ? -36.09  2.994   -2.006  1    47.44  ? 349 LYS B CG  1 
ATOM   3874 C  CD  . LYS B 2 179 ? -37.266 3.845   -2.506  1    47.08  ? 349 LYS B CD  1 
ATOM   3875 C  CE  . LYS B 2 179 ? -37.111 5.285   -2.137  1    49.4   ? 349 LYS B CE  1 
ATOM   3876 N  NZ  . LYS B 2 179 ? -37.993 6.132   -2.953  1    54.76  ? 349 LYS B NZ  1 
ATOM   3877 N  N   . TYR B 2 180 ? -33.638 0.453   -1.372  1    36.06  ? 350 TYR B N   1 
ATOM   3878 C  CA  . TYR B 2 180 ? -33.427 -0.835  -2.02   1    37.76  ? 350 TYR B CA  1 
ATOM   3879 C  C   . TYR B 2 180 ? -32.325 -1.635  -1.315  1    41.06  ? 350 TYR B C   1 
ATOM   3880 O  O   . TYR B 2 180 ? -31.403 -1.077  -0.708  1    37.67  ? 350 TYR B O   1 
ATOM   3881 C  CB  . TYR B 2 180 ? -33.112 -0.628  -3.5    1    34.23  ? 350 TYR B CB  1 
ATOM   3882 C  CG  . TYR B 2 180 ? -34.166 0.157   -4.262  1    33.95  ? 350 TYR B CG  1 
ATOM   3883 C  CD1 . TYR B 2 180 ? -35.424 -0.382  -4.537  1    33.37  ? 350 TYR B CD1 1 
ATOM   3884 C  CD2 . TYR B 2 180 ? -33.886 1.439   -4.726  1    32.53  ? 350 TYR B CD2 1 
ATOM   3885 C  CE1 . TYR B 2 180 ? -36.354 0.33    -5.281  1    32.37  ? 350 TYR B CE1 1 
ATOM   3886 C  CE2 . TYR B 2 180 ? -34.823 2.165   -5.446  1    29.88  ? 350 TYR B CE2 1 
ATOM   3887 C  CZ  . TYR B 2 180 ? -36.061 1.618   -5.716  1    31.6   ? 350 TYR B CZ  1 
ATOM   3888 O  OH  . TYR B 2 180 ? -36.947 2.383   -6.429  1    31.84  ? 350 TYR B OH  1 
ATOM   3889 N  N   . LEU B 2 181 ? -32.453 -2.969  -1.376  1    41.89  ? 351 LEU B N   1 
ATOM   3890 C  CA  . LEU B 2 181 ? -31.436 -3.87   -0.843  1    41.77  ? 351 LEU B CA  1 
ATOM   3891 C  C   . LEU B 2 181 ? -30.323 -4.01   -1.875  1    38.15  ? 351 LEU B C   1 
ATOM   3892 O  O   . LEU B 2 181 ? -30.561 -3.951  -3.09   1    36.56  ? 351 LEU B O   1 
ATOM   3893 C  CB  . LEU B 2 181 ? -32.041 -5.238  -0.524  1    40.87  ? 351 LEU B CB  1 
ATOM   3894 C  CG  . LEU B 2 181 ? -33.037 -5.283  0.637   1    34.94  ? 351 LEU B CG  1 
ATOM   3895 C  CD1 . LEU B 2 181 ? -33.782 -6.604  0.736   1    31.86  ? 351 LEU B CD1 1 
ATOM   3896 C  CD2 . LEU B 2 181 ? -32.304 -4.993  1.946   1    33.13  ? 351 LEU B CD2 1 
ATOM   3897 N  N   . PRO B 2 182 ? -29.076 -4.198  -1.417  1    36.53  ? 352 PRO B N   1 
ATOM   3898 C  CA  . PRO B 2 182 ? -27.952 -4.46   -2.338  1    33.56  ? 352 PRO B CA  1 
ATOM   3899 C  C   . PRO B 2 182 ? -28.283 -5.46   -3.443  1    30.3   ? 352 PRO B C   1 
ATOM   3900 O  O   . PRO B 2 182 ? -27.987 -5.245  -4.615  1    36.39  ? 352 PRO B O   1 
ATOM   3901 C  CB  . PRO B 2 182 ? -26.858 -4.98   -1.384  1    29.24  ? 352 PRO B CB  1 
ATOM   3902 C  CG  . PRO B 2 182 ? -27.159 -4.262  -0.068  1    32.97  ? 352 PRO B CG  1 
ATOM   3903 C  CD  . PRO B 2 182 ? -28.686 -4.128  0       1    32.3   ? 352 PRO B CD  1 
ATOM   3904 N  N   . SER B 2 183 ? -28.901 -6.571  -3.074  1    29.62  ? 353 SER B N   1 
ATOM   3905 C  CA  . SER B 2 183 ? -29.24  -7.617  -4.029  1    32.57  ? 353 SER B CA  1 
ATOM   3906 C  C   . SER B 2 183 ? -30.158 -7.1    -5.151  1    37.04  ? 353 SER B C   1 
ATOM   3907 O  O   . SER B 2 183 ? -30.057 -7.603  -6.279  1    35.85  ? 353 SER B O   1 
ATOM   3908 C  CB  . SER B 2 183 ? -29.852 -8.822  -3.313  1    31.73  ? 353 SER B CB  1 
ATOM   3909 O  OG  . SER B 2 183 ? -31.175 -8.563  -2.865  1    28.89  ? 353 SER B OG  1 
ATOM   3910 N  N   . VAL B 2 184 ? -31.038 -6.116  -4.839  1    30.25  ? 354 VAL B N   1 
ATOM   3911 C  CA  . VAL B 2 184 ? -31.962 -5.554  -5.813  1    30.11  ? 354 VAL B CA  1 
ATOM   3912 C  C   . VAL B 2 184 ? -31.281 -4.512  -6.712  1    32.83  ? 354 VAL B C   1 
ATOM   3913 O  O   . VAL B 2 184 ? -31.515 -4.492  -7.924  1    32.87  ? 354 VAL B O   1 
ATOM   3914 C  CB  . VAL B 2 184 ? -33.237 -5.007  -5.16   1    30.18  ? 354 VAL B CB  1 
ATOM   3915 C  CG1 . VAL B 2 184 ? -34.073 -4.253  -6.185  1    27.22  ? 354 VAL B CG1 1 
ATOM   3916 C  CG2 . VAL B 2 184 ? -34.027 -6.127  -4.457  1    22.79  ? 354 VAL B CG2 1 
ATOM   3917 N  N   . ILE B 2 185 ? -30.443 -3.637  -6.143  1    28.6   ? 355 ILE B N   1 
ATOM   3918 C  CA  . ILE B 2 185 ? -29.715 -2.68   -6.96   1    31.81  ? 355 ILE B CA  1 
ATOM   3919 C  C   . ILE B 2 185 ? -28.767 -3.394  -7.941  1    37.56  ? 355 ILE B C   1 
ATOM   3920 O  O   . ILE B 2 185 ? -28.622 -3.002  -9.11   1    37.84  ? 355 ILE B O   1 
ATOM   3921 C  CB  . ILE B 2 185 ? -28.955 -1.683  -6.077  1    32.17  ? 355 ILE B CB  1 
ATOM   3922 C  CG1 . ILE B 2 185 ? -29.897 -0.709  -5.379  1    32.46  ? 355 ILE B CG1 1 
ATOM   3923 C  CG2 . ILE B 2 185 ? -27.9   -0.939  -6.896  1    30.8   ? 355 ILE B CG2 1 
ATOM   3924 C  CD1 . ILE B 2 185 ? -29.253 -0.001  -4.186  1    27.99  ? 355 ILE B CD1 1 
ATOM   3925 N  N   . ALA B 2 186 ? -28.105 -4.443  -7.453  1    36.56  ? 356 ALA B N   1 
ATOM   3926 C  CA  . ALA B 2 186 ? -27.22  -5.255  -8.275  1    33.45  ? 356 ALA B CA  1 
ATOM   3927 C  C   . ALA B 2 186 ? -28.012 -5.9    -9.416  1    31.71  ? 356 ALA B C   1 
ATOM   3928 O  O   . ALA B 2 186 ? -27.496 -6.082  -10.51  1    36.45  ? 356 ALA B O   1 
ATOM   3929 C  CB  . ALA B 2 186 ? -26.542 -6.291  -7.4    1    28.49  ? 356 ALA B CB  1 
ATOM   3930 N  N   . ALA B 2 187 ? -29.263 -6.282  -9.155  1    31.12  ? 357 ALA B N   1 
ATOM   3931 C  CA  . ALA B 2 187 ? -30.061 -6.926  -10.178 1    29.38  ? 357 ALA B CA  1 
ATOM   3932 C  C   . ALA B 2 187 ? -30.407 -5.885  -11.221 1    30.73  ? 357 ALA B C   1 
ATOM   3933 O  O   . ALA B 2 187 ? -30.24  -6.142  -12.409 1    34.5   ? 357 ALA B O   1 
ATOM   3934 C  CB  . ALA B 2 187 ? -31.309 -7.548  -9.6    1    28.72  ? 357 ALA B CB  1 
ATOM   3935 N  N   . ALA B 2 188 ? -30.834 -4.704  -10.758 1    30.61  ? 358 ALA B N   1 
ATOM   3936 C  CA  . ALA B 2 188 ? -31.206 -3.642  -11.677 1    31.97  ? 358 ALA B CA  1 
ATOM   3937 C  C   . ALA B 2 188 ? -29.98  -3.257  -12.509 1    32.83  ? 358 ALA B C   1 
ATOM   3938 O  O   . ALA B 2 188 ? -30.068 -3.076  -13.727 1    29.32  ? 358 ALA B O   1 
ATOM   3939 C  CB  . ALA B 2 188 ? -31.773 -2.462  -10.921 1    28.15  ? 358 ALA B CB  1 
ATOM   3940 N  N   . ALA B 2 189 ? -28.831 -3.168  -11.829 1    31.12  ? 359 ALA B N   1 
ATOM   3941 C  CA  . ALA B 2 189 ? -27.603 -2.724  -12.461 1    30.31  ? 359 ALA B CA  1 
ATOM   3942 C  C   . ALA B 2 189 ? -27.211 -3.722  -13.544 1    32.34  ? 359 ALA B C   1 
ATOM   3943 O  O   . ALA B 2 189 ? -26.857 -3.334  -14.663 1    31.43  ? 359 ALA B O   1 
ATOM   3944 C  CB  . ALA B 2 189 ? -26.527 -2.574  -11.409 1    26.25  ? 359 ALA B CB  1 
ATOM   3945 N  N   . PHE B 2 190 ? -27.297 -5.012  -13.195 1    30.3   ? 360 PHE B N   1 
ATOM   3946 C  CA  . PHE B 2 190 ? -26.901 -6.069  -14.112 1    31.28  ? 360 PHE B CA  1 
ATOM   3947 C  C   . PHE B 2 190 ? -27.818 -6.07   -15.341 1    33.03  ? 360 PHE B C   1 
ATOM   3948 O  O   . PHE B 2 190 ? -27.351 -6.24   -16.46  1    35.18  ? 360 PHE B O   1 
ATOM   3949 C  CB  . PHE B 2 190 ? -26.844 -7.421  -13.401 1    29.14  ? 360 PHE B CB  1 
ATOM   3950 C  CG  . PHE B 2 190 ? -26.475 -8.551  -14.342 1    32.7   ? 360 PHE B CG  1 
ATOM   3951 C  CD1 . PHE B 2 190 ? -25.202 -8.63   -14.888 1    33.33  ? 360 PHE B CD1 1 
ATOM   3952 C  CD2 . PHE B 2 190 ? -27.398 -9.531  -14.688 1    34.59  ? 360 PHE B CD2 1 
ATOM   3953 C  CE1 . PHE B 2 190 ? -24.857 -9.675  -15.737 1    35.59  ? 360 PHE B CE1 1 
ATOM   3954 C  CE2 . PHE B 2 190 ? -27.048 -10.569 -15.55  1    37.9   ? 360 PHE B CE2 1 
ATOM   3955 C  CZ  . PHE B 2 190 ? -25.783 -10.641 -16.082 1    33.39  ? 360 PHE B CZ  1 
ATOM   3956 N  N   . HIS B 2 191 ? -29.124 -5.856  -15.152 1    31.6   ? 361 HIS B N   1 
ATOM   3957 C  CA  . HIS B 2 191 ? -30.04  -5.915  -16.28  1    28.73  ? 361 HIS B CA  1 
ATOM   3958 C  C   . HIS B 2 191 ? -29.799 -4.72   -17.192 1    31.67  ? 361 HIS B C   1 
ATOM   3959 O  O   . HIS B 2 191 ? -29.902 -4.814  -18.424 1    30.99  ? 361 HIS B O   1 
ATOM   3960 C  CB  . HIS B 2 191 ? -31.497 -5.904  -15.829 1    26.21  ? 361 HIS B CB  1 
ATOM   3961 C  CG  . HIS B 2 191 ? -32.42  -5.558  -16.937 1    26.6   ? 361 HIS B CG  1 
ATOM   3962 N  ND1 . HIS B 2 191 ? -32.792 -6.477  -17.9   1    26.63  ? 361 HIS B ND1 1 
ATOM   3963 C  CD2 . HIS B 2 191 ? -33.03  -4.381  -17.25  1    27.17  ? 361 HIS B CD2 1 
ATOM   3964 C  CE1 . HIS B 2 191 ? -33.637 -5.902  -18.755 1    28.11  ? 361 HIS B CE1 1 
ATOM   3965 N  NE2 . HIS B 2 191 ? -33.792 -4.626  -18.385 1    31.39  ? 361 HIS B NE2 1 
ATOM   3966 N  N   . LEU B 2 192 ? -29.493 -3.581  -16.565 1    29.25  ? 362 LEU B N   1 
ATOM   3967 C  CA  . LEU B 2 192 ? -29.406 -2.359  -17.335 1    29.61  ? 362 LEU B CA  1 
ATOM   3968 C  C   . LEU B 2 192 ? -28.116 -2.416  -18.152 1    29.8   ? 362 LEU B C   1 
ATOM   3969 O  O   . LEU B 2 192 ? -28.099 -2.037  -19.321 1    28.82  ? 362 LEU B O   1 
ATOM   3970 C  CB  . LEU B 2 192 ? -29.5   -1.21   -16.341 1    28.74  ? 362 LEU B CB  1 
ATOM   3971 C  CG  . LEU B 2 192 ? -29.533 0.192   -16.937 1    33.42  ? 362 LEU B CG  1 
ATOM   3972 C  CD1 . LEU B 2 192 ? -30.682 0.332   -17.937 1    33.21  ? 362 LEU B CD1 1 
ATOM   3973 C  CD2 . LEU B 2 192 ? -29.6   1.221   -15.808 1    30.59  ? 362 LEU B CD2 1 
ATOM   3974 N  N   . ALA B 2 193 ? -27.083 -3.029  -17.562 1    28.25  ? 363 ALA B N   1 
ATOM   3975 C  CA  . ALA B 2 193 ? -25.792 -3.118  -18.213 1    31.87  ? 363 ALA B CA  1 
ATOM   3976 C  C   . ALA B 2 193 ? -25.902 -4.041  -19.416 1    34.03  ? 363 ALA B C   1 
ATOM   3977 O  O   . ALA B 2 193 ? -25.42  -3.722  -20.512 1    35.72  ? 363 ALA B O   1 
ATOM   3978 C  CB  . ALA B 2 193 ? -24.753 -3.573  -17.24  1    29.18  ? 363 ALA B CB  1 
ATOM   3979 N  N   . LEU B 2 194 ? -26.584 -5.155  -19.177 1    32.33  ? 364 LEU B N   1 
ATOM   3980 C  CA  . LEU B 2 194 ? -26.826 -6.198  -20.156 1    33.31  ? 364 LEU B CA  1 
ATOM   3981 C  C   . LEU B 2 194 ? -27.668 -5.643  -21.293 1    38.27  ? 364 LEU B C   1 
ATOM   3982 O  O   . LEU B 2 194 ? -27.331 -5.806  -22.466 1    43.22  ? 364 LEU B O   1 
ATOM   3983 C  CB  . LEU B 2 194 ? -27.596 -7.285  -19.404 1    38.19  ? 364 LEU B CB  1 
ATOM   3984 C  CG  . LEU B 2 194 ? -27.729 -8.627  -20.111 1    47.72  ? 364 LEU B CG  1 
ATOM   3985 C  CD1 . LEU B 2 194 ? -26.351 -9.269  -20.333 1    48.83  ? 364 LEU B CD1 1 
ATOM   3986 C  CD2 . LEU B 2 194 ? -28.615 -9.498  -19.249 1    49.73  ? 364 LEU B CD2 1 
ATOM   3987 N  N   . TYR B 2 195 ? -28.781 -4.993  -20.94  1    39     ? 365 TYR B N   1 
ATOM   3988 C  CA  . TYR B 2 195 ? -29.647 -4.433  -21.963 1    34.94  ? 365 TYR B CA  1 
ATOM   3989 C  C   . TYR B 2 195 ? -28.865 -3.416  -22.799 1    35.41  ? 365 TYR B C   1 
ATOM   3990 O  O   . TYR B 2 195 ? -29.008 -3.393  -24.011 1    30.19  ? 365 TYR B O   1 
ATOM   3991 C  CB  . TYR B 2 195 ? -30.879 -3.811  -21.312 1    31.52  ? 365 TYR B CB  1 
ATOM   3992 C  CG  . TYR B 2 195 ? -31.874 -3.316  -22.34  1    34.56  ? 365 TYR B CG  1 
ATOM   3993 C  CD1 . TYR B 2 195 ? -32.439 -4.187  -23.274 1    35.22  ? 365 TYR B CD1 1 
ATOM   3994 C  CD2 . TYR B 2 195 ? -32.219 -1.974  -22.408 1    35.4   ? 365 TYR B CD2 1 
ATOM   3995 C  CE1 . TYR B 2 195 ? -33.365 -3.753  -24.213 1    33.46  ? 365 TYR B CE1 1 
ATOM   3996 C  CE2 . TYR B 2 195 ? -33.132 -1.528  -23.354 1    38.21  ? 365 TYR B CE2 1 
ATOM   3997 C  CZ  . TYR B 2 195 ? -33.705 -2.411  -24.258 1    37     ? 365 TYR B CZ  1 
ATOM   3998 O  OH  . TYR B 2 195 ? -34.601 -1.945  -25.184 1    44.2   ? 365 TYR B OH  1 
ATOM   3999 N  N   . THR B 2 196 ? -28.031 -2.591  -22.14  1    33.5   ? 366 THR B N   1 
ATOM   4000 C  CA  . THR B 2 196 ? -27.326 -1.499  -22.8   1    30.79  ? 366 THR B CA  1 
ATOM   4001 C  C   . THR B 2 196 ? -26.304 -2.056  -23.78  1    27.7   ? 366 THR B C   1 
ATOM   4002 O  O   . THR B 2 196 ? -26.194 -1.537  -24.859 1    28.96  ? 366 THR B O   1 
ATOM   4003 C  CB  . THR B 2 196 ? -26.633 -0.561  -21.808 1    32.16  ? 366 THR B CB  1 
ATOM   4004 O  OG1 . THR B 2 196 ? -27.568 -0.02   -20.881 1    33.26  ? 366 THR B OG1 1 
ATOM   4005 C  CG2 . THR B 2 196 ? -25.912 0.591   -22.488 1    23.61  ? 366 THR B CG2 1 
ATOM   4006 N  N   . VAL B 2 197 ? -25.552 -3.09   -23.394 1    33     ? 367 VAL B N   1 
ATOM   4007 C  CA  . VAL B 2 197 ? -24.395 -3.552  -24.153 1    31.43  ? 367 VAL B CA  1 
ATOM   4008 C  C   . VAL B 2 197 ? -24.834 -4.522  -25.25  1    28.62  ? 367 VAL B C   1 
ATOM   4009 O  O   . VAL B 2 197 ? -24.406 -4.372  -26.397 1    30.91  ? 367 VAL B O   1 
ATOM   4010 C  CB  . VAL B 2 197 ? -23.307 -4.177  -23.251 1    38.05  ? 367 VAL B CB  1 
ATOM   4011 C  CG1 . VAL B 2 197 ? -22.278 -4.963  -24.059 1    39.66  ? 367 VAL B CG1 1 
ATOM   4012 C  CG2 . VAL B 2 197 ? -22.611 -3.146  -22.373 1    34.08  ? 367 VAL B CG2 1 
ATOM   4013 N  N   . THR B 2 198 ? -25.701 -5.49   -24.899 1    28.3   ? 368 THR B N   1 
ATOM   4014 C  CA  . THR B 2 198 ? -26.063 -6.617  -25.765 1    27.12  ? 368 THR B CA  1 
ATOM   4015 C  C   . THR B 2 198 ? -27.538 -6.632  -26.159 1    29.07  ? 368 THR B C   1 
ATOM   4016 O  O   . THR B 2 198 ? -27.939 -7.529  -26.893 1    32.75  ? 368 THR B O   1 
ATOM   4017 C  CB  . THR B 2 198 ? -25.816 -7.949  -25.069 1    27.83  ? 368 THR B CB  1 
ATOM   4018 O  OG1 . THR B 2 198 ? -26.812 -8.051  -24.046 1    29.75  ? 368 THR B OG1 1 
ATOM   4019 C  CG2 . THR B 2 198 ? -24.394 -8.099  -24.568 1    27.74  ? 368 THR B CG2 1 
ATOM   4020 N  N   . GLY B 2 199 ? -28.365 -5.749  -25.579 1    28.45  ? 369 GLY B N   1 
ATOM   4021 C  CA  . GLY B 2 199 ? -29.785 -5.722  -25.877 1    27.69  ? 369 GLY B CA  1 
ATOM   4022 C  C   . GLY B 2 199 ? -30.576 -6.815  -25.161 1    34.29  ? 369 GLY B C   1 
ATOM   4023 O  O   . GLY B 2 199 ? -31.777 -6.923  -25.36  1    40.23  ? 369 GLY B O   1 
ATOM   4024 N  N   . GLN B 2 200 ? -29.919 -7.606  -24.308 1    38.6   ? 370 GLN B N   1 
ATOM   4025 C  CA  . GLN B 2 200 ? -30.556 -8.752  -23.683 1    40.16  ? 370 GLN B CA  1 
ATOM   4026 C  C   . GLN B 2 200 ? -31.129 -8.37   -22.322 1    42.68  ? 370 GLN B C   1 
ATOM   4027 O  O   . GLN B 2 200 ? -30.913 -7.258  -21.844 1    48.51  ? 370 GLN B O   1 
ATOM   4028 C  CB  . GLN B 2 200 ? -29.526 -9.866  -23.56  1    48.1   ? 370 GLN B CB  1 
ATOM   4029 C  CG  . GLN B 2 200 ? -29.19  -10.537 -24.88  1    58.21  ? 370 GLN B CG  1 
ATOM   4030 C  CD  . GLN B 2 200 ? -28.18  -11.629 -24.651 1    70.16  ? 370 GLN B CD  1 
ATOM   4031 O  OE1 . GLN B 2 200 ? -28.42  -12.785 -25.002 1    90.86  ? 370 GLN B OE1 1 
ATOM   4032 N  NE2 . GLN B 2 200 ? -27.062 -11.265 -24.034 1    67.1   ? 370 GLN B NE2 1 
ATOM   4033 N  N   . SER B 2 201 ? -31.86  -9.303  -21.706 1    39.18  ? 371 SER B N   1 
ATOM   4034 C  CA  . SER B 2 201 ? -32.579 -8.987  -20.486 1    36.14  ? 371 SER B CA  1 
ATOM   4035 C  C   . SER B 2 201 ? -32.201 -9.95   -19.374 1    38.73  ? 371 SER B C   1 
ATOM   4036 O  O   . SER B 2 201 ? -31.719 -11.046 -19.645 1    40.18  ? 371 SER B O   1 
ATOM   4037 C  CB  . SER B 2 201 ? -34.065 -8.994  -20.686 1    33.49  ? 371 SER B CB  1 
ATOM   4038 O  OG  . SER B 2 201 ? -34.478 -7.745  -21.207 1    41.95  ? 371 SER B OG  1 
ATOM   4039 N  N   . TRP B 2 202 ? -32.461 -9.513  -18.132 1    38.04  ? 372 TRP B N   1 
ATOM   4040 C  CA  . TRP B 2 202 ? -32.333 -10.306 -16.919 1    36.49  ? 372 TRP B CA  1 
ATOM   4041 C  C   . TRP B 2 202 ? -32.677 -11.764 -17.221 1    36.45  ? 372 TRP B C   1 
ATOM   4042 O  O   . TRP B 2 202 ? -33.802 -12.096 -17.573 1    35.97  ? 372 TRP B O   1 
ATOM   4043 C  CB  . TRP B 2 202 ? -33.261 -9.686  -15.86  1    36.66  ? 372 TRP B CB  1 
ATOM   4044 C  CG  . TRP B 2 202 ? -33.317 -10.347 -14.513 1    33.41  ? 372 TRP B CG  1 
ATOM   4045 C  CD1 . TRP B 2 202 ? -34.374 -11.051 -14.029 1    32.22  ? 372 TRP B CD1 1 
ATOM   4046 C  CD2 . TRP B 2 202 ? -32.322 -10.342 -13.469 1    37.02  ? 372 TRP B CD2 1 
ATOM   4047 N  NE1 . TRP B 2 202 ? -34.115 -11.48  -12.757 1    34.09  ? 372 TRP B NE1 1 
ATOM   4048 C  CE2 . TRP B 2 202 ? -32.864 -11.075 -12.387 1    36.41  ? 372 TRP B CE2 1 
ATOM   4049 C  CE3 . TRP B 2 202 ? -31.031 -9.815  -13.331 1    37.05  ? 372 TRP B CE3 1 
ATOM   4050 C  CZ2 . TRP B 2 202 ? -32.166 -11.299 -11.206 1    34.11  ? 372 TRP B CZ2 1 
ATOM   4051 C  CZ3 . TRP B 2 202 ? -30.335 -10.031 -12.163 1    33.11  ? 372 TRP B CZ3 1 
ATOM   4052 C  CH2 . TRP B 2 202 ? -30.901 -10.761 -11.12  1    36.29  ? 372 TRP B CH2 1 
ATOM   4053 N  N   . PRO B 2 203 ? -31.705 -12.686 -17.087 1    35.55  ? 373 PRO B N   1 
ATOM   4054 C  CA  . PRO B 2 203 ? -31.913 -14.085 -17.496 1    30.31  ? 373 PRO B CA  1 
ATOM   4055 C  C   . PRO B 2 203 ? -32.825 -14.891 -16.575 1    31.3   ? 373 PRO B C   1 
ATOM   4056 O  O   . PRO B 2 203 ? -32.909 -14.659 -15.354 1    31.54  ? 373 PRO B O   1 
ATOM   4057 C  CB  . PRO B 2 203 ? -30.498 -14.652 -17.46  1    32.36  ? 373 PRO B CB  1 
ATOM   4058 C  CG  . PRO B 2 203 ? -29.755 -13.786 -16.413 1    39.08  ? 373 PRO B CG  1 
ATOM   4059 C  CD  . PRO B 2 203 ? -30.361 -12.391 -16.543 1    37.28  ? 373 PRO B CD  1 
ATOM   4060 N  N   . GLU B 2 204 ? -33.481 -15.878 -17.18  1    31.06  ? 374 GLU B N   1 
ATOM   4061 C  CA  . GLU B 2 204 ? -34.396 -16.75  -16.467 1    36.69  ? 374 GLU B CA  1 
ATOM   4062 C  C   . GLU B 2 204 ? -33.636 -17.501 -15.375 1    31.82  ? 374 GLU B C   1 
ATOM   4063 O  O   . GLU B 2 204 ? -34.197 -17.838 -14.328 1    32.66  ? 374 GLU B O   1 
ATOM   4064 C  CB  . GLU B 2 204 ? -35.05  -17.655 -17.517 1    40.66  ? 374 GLU B CB  1 
ATOM   4065 C  CG  . GLU B 2 204 ? -36.116 -18.615 -16.981 1    47.66  ? 374 GLU B CG  1 
ATOM   4066 C  CD  . GLU B 2 204 ? -35.585 -19.871 -16.32  1    51.27  ? 374 GLU B CD  1 
ATOM   4067 O  OE1 . GLU B 2 204 ? -34.445 -20.302 -16.64  1    63.89  ? 374 GLU B OE1 1 
ATOM   4068 O  OE2 . GLU B 2 204 ? -36.314 -20.4   -15.461 1    55.34  ? 374 GLU B OE2 1 
ATOM   4069 N  N   . SER B 2 205 ? -32.39  -17.847 -15.683 1    27.27  ? 375 SER B N   1 
ATOM   4070 C  CA  . SER B 2 205 ? -31.555 -18.508 -14.71  1    31.41  ? 375 SER B CA  1 
ATOM   4071 C  C   . SER B 2 205 ? -31.4   -17.644 -13.444 1    30.93  ? 375 SER B C   1 
ATOM   4072 O  O   . SER B 2 205 ? -31.205 -18.191 -12.364 1    31.52  ? 375 SER B O   1 
ATOM   4073 C  CB  . SER B 2 205 ? -30.232 -18.91  -15.33  1    35.43  ? 375 SER B CB  1 
ATOM   4074 O  OG  . SER B 2 205 ? -29.304 -17.828 -15.405 1    46.15  ? 375 SER B OG  1 
ATOM   4075 N  N   . LEU B 2 206 ? -31.489 -16.306 -13.552 1    28.66  ? 376 LEU B N   1 
ATOM   4076 C  CA  . LEU B 2 206 ? -31.309 -15.453 -12.377 1    30.07  ? 376 LEU B CA  1 
ATOM   4077 C  C   . LEU B 2 206 ? -32.639 -15.23  -11.664 1    29.1   ? 376 LEU B C   1 
ATOM   4078 O  O   . LEU B 2 206 ? -32.649 -15.011 -10.453 1    28.35  ? 376 LEU B O   1 
ATOM   4079 C  CB  . LEU B 2 206 ? -30.612 -14.127 -12.677 1    28.39  ? 376 LEU B CB  1 
ATOM   4080 C  CG  . LEU B 2 206 ? -29.084 -14.181 -12.781 1    27.61  ? 376 LEU B CG  1 
ATOM   4081 C  CD1 . LEU B 2 206 ? -28.515 -12.833 -13.134 1    33.46  ? 376 LEU B CD1 1 
ATOM   4082 C  CD2 . LEU B 2 206 ? -28.469 -14.654 -11.489 1    26.32  ? 376 LEU B CD2 1 
ATOM   4083 N  N   . VAL B 2 207 ? -33.731 -15.33  -12.439 1    28.32  ? 377 VAL B N   1 
ATOM   4084 C  CA  . VAL B 2 207 ? -35.062 -15.494 -11.874 1    31.86  ? 377 VAL B CA  1 
ATOM   4085 C  C   . VAL B 2 207 ? -35.074 -16.708 -10.927 1    32.83  ? 377 VAL B C   1 
ATOM   4086 O  O   . VAL B 2 207 ? -35.49  -16.598 -9.783  1    30.49  ? 377 VAL B O   1 
ATOM   4087 C  CB  . VAL B 2 207 ? -36.162 -15.579 -12.958 1    31.45  ? 377 VAL B CB  1 
ATOM   4088 C  CG1 . VAL B 2 207 ? -37.555 -15.7   -12.331 1    26.02  ? 377 VAL B CG1 1 
ATOM   4089 C  CG2 . VAL B 2 207 ? -36.119 -14.393 -13.907 1    26.81  ? 377 VAL B CG2 1 
ATOM   4090 N  N   . GLN B 2 208 ? -34.599 -17.868 -11.402 1    34.76  ? 378 GLN B N   1 
ATOM   4091 C  CA  . GLN B 2 208 ? -34.51  -19.063 -10.567 1    34.44  ? 378 GLN B CA  1 
ATOM   4092 C  C   . GLN B 2 208 ? -33.701 -18.794 -9.297  1    33.15  ? 378 GLN B C   1 
ATOM   4093 O  O   . GLN B 2 208 ? -34.12  -19.199 -8.218  1    32.18  ? 378 GLN B O   1 
ATOM   4094 C  CB  . GLN B 2 208 ? -33.807 -20.215 -11.283 1    30.67  ? 378 GLN B CB  1 
ATOM   4095 C  CG  . GLN B 2 208 ? -34.573 -20.795 -12.457 1    36.37  ? 378 GLN B CG  1 
ATOM   4096 C  CD  . GLN B 2 208 ? -35.876 -21.429 -12.031 1    40.34  ? 378 GLN B CD  1 
ATOM   4097 O  OE1 . GLN B 2 208 ? -36.9   -21.293 -12.707 1    39.33  ? 378 GLN B OE1 1 
ATOM   4098 N  NE2 . GLN B 2 208 ? -35.855 -22.142 -10.913 1    40.27  ? 378 GLN B NE2 1 
ATOM   4099 N  N   . LYS B 2 209 ? -32.528 -18.159 -9.44   1    28.77  ? 379 LYS B N   1 
ATOM   4100 C  CA  . LYS B 2 209 ? -31.619 -18.044 -8.315  1    32.78  ? 379 LYS B CA  1 
ATOM   4101 C  C   . LYS B 2 209 ? -32.171 -17.078 -7.262  1    34.87  ? 379 LYS B C   1 
ATOM   4102 O  O   . LYS B 2 209 ? -32.129 -17.38  -6.066  1    33.92  ? 379 LYS B O   1 
ATOM   4103 C  CB  . LYS B 2 209 ? -30.273 -17.508 -8.799  1    35.23  ? 379 LYS B CB  1 
ATOM   4104 C  CG  . LYS B 2 209 ? -29.187 -17.4   -7.731  1    38.92  ? 379 LYS B CG  1 
ATOM   4105 C  CD  . LYS B 2 209 ? -27.963 -16.629 -8.239  1    42.73  ? 379 LYS B CD  1 
ATOM   4106 C  CE  . LYS B 2 209 ? -26.856 -16.561 -7.215  1    45.52  ? 379 LYS B CE  1 
ATOM   4107 N  NZ  . LYS B 2 209 ? -26.478 -17.889 -6.729  1    42.73  ? 379 LYS B NZ  1 
ATOM   4108 N  N   . THR B 2 210 ? -32.708 -15.935 -7.726  1    31.35  ? 380 THR B N   1 
ATOM   4109 C  CA  . THR B 2 210 ? -32.962 -14.793 -6.858  1    31.42  ? 380 THR B CA  1 
ATOM   4110 C  C   . THR B 2 210 ? -34.437 -14.702 -6.475  1    31.67  ? 380 THR B C   1 
ATOM   4111 O  O   . THR B 2 210 ? -34.749 -14.105 -5.45   1    32.76  ? 380 THR B O   1 
ATOM   4112 C  CB  . THR B 2 210 ? -32.539 -13.475 -7.518  1    30.84  ? 380 THR B CB  1 
ATOM   4113 O  OG1 . THR B 2 210 ? -33.34  -13.224 -8.678  1    30.45  ? 380 THR B OG1 1 
ATOM   4114 C  CG2 . THR B 2 210 ? -31.077 -13.466 -7.909  1    30.04  ? 380 THR B CG2 1 
ATOM   4115 N  N   . GLY B 2 211 ? -35.328 -15.223 -7.323  1    27.96  ? 381 GLY B N   1 
ATOM   4116 C  CA  . GLY B 2 211 ? -36.749 -14.948 -7.174  1    28.65  ? 381 GLY B CA  1 
ATOM   4117 C  C   . GLY B 2 211 ? -37.182 -13.611 -7.8    1    30.63  ? 381 GLY B C   1 
ATOM   4118 O  O   . GLY B 2 211 ? -38.371 -13.363 -7.943  1    33.91  ? 381 GLY B O   1 
ATOM   4119 N  N   . TYR B 2 212 ? -36.235 -12.777 -8.239  1    28.12  ? 382 TYR B N   1 
ATOM   4120 C  CA  . TYR B 2 212 ? -36.578 -11.469 -8.77   1    27.86  ? 382 TYR B CA  1 
ATOM   4121 C  C   . TYR B 2 212 ? -36.947 -11.583 -10.25  1    30.15  ? 382 TYR B C   1 
ATOM   4122 O  O   . TYR B 2 212 ? -36.348 -12.353 -10.983 1    32.4   ? 382 TYR B O   1 
ATOM   4123 C  CB  . TYR B 2 212 ? -35.383 -10.516 -8.634  1    29.64  ? 382 TYR B CB  1 
ATOM   4124 C  CG  . TYR B 2 212 ? -34.866 -10.246 -7.226  1    31.22  ? 382 TYR B CG  1 
ATOM   4125 C  CD1 . TYR B 2 212 ? -35.713 -10.346 -6.108  1    30.44  ? 382 TYR B CD1 1 
ATOM   4126 C  CD2 . TYR B 2 212 ? -33.546 -9.848  -7.026  1    26.25  ? 382 TYR B CD2 1 
ATOM   4127 C  CE1 . TYR B 2 212 ? -35.244 -10.083 -4.833  1    27.56  ? 382 TYR B CE1 1 
ATOM   4128 C  CE2 . TYR B 2 212 ? -33.072 -9.566  -5.751  1    30.15  ? 382 TYR B CE2 1 
ATOM   4129 C  CZ  . TYR B 2 212 ? -33.917 -9.71   -4.657  1    29.96  ? 382 TYR B CZ  1 
ATOM   4130 O  OH  . TYR B 2 212 ? -33.468 -9.441  -3.403  1    33.26  ? 382 TYR B OH  1 
ATOM   4131 N  N   . THR B 2 213 ? -37.952 -10.821 -10.68  1    32.2   ? 383 THR B N   1 
ATOM   4132 C  CA  . THR B 2 213 ? -38.289 -10.672 -12.092 1    34.94  ? 383 THR B CA  1 
ATOM   4133 C  C   . THR B 2 213 ? -38.168 -9.196  -12.45  1    36.38  ? 383 THR B C   1 
ATOM   4134 O  O   . THR B 2 213 ? -38.022 -8.345  -11.568 1    38.83  ? 383 THR B O   1 
ATOM   4135 C  CB  . THR B 2 213 ? -39.731 -11.104 -12.366 1    32.92  ? 383 THR B CB  1 
ATOM   4136 O  OG1 . THR B 2 213 ? -40.546 -10.194 -11.631 1    39.65  ? 383 THR B OG1 1 
ATOM   4137 C  CG2 . THR B 2 213 ? -40.044 -12.522 -11.936 1    29     ? 383 THR B CG2 1 
ATOM   4138 N  N   . LEU B 2 214 ? -38.31  -8.895  -13.737 1    35.63  ? 384 LEU B N   1 
ATOM   4139 C  CA  . LEU B 2 214 ? -38.294 -7.506  -14.165 1    37.11  ? 384 LEU B CA  1 
ATOM   4140 C  C   . LEU B 2 214 ? -39.407 -6.731  -13.488 1    37.81  ? 384 LEU B C   1 
ATOM   4141 O  O   . LEU B 2 214 ? -39.27  -5.535  -13.309 1    42.3   ? 384 LEU B O   1 
ATOM   4142 C  CB  . LEU B 2 214 ? -38.404 -7.387  -15.676 1    32.9   ? 384 LEU B CB  1 
ATOM   4143 C  CG  . LEU B 2 214 ? -37.122 -7.721  -16.431 1    35.2   ? 384 LEU B CG  1 
ATOM   4144 C  CD1 . LEU B 2 214 ? -37.37  -7.619  -17.924 1    33.93  ? 384 LEU B CD1 1 
ATOM   4145 C  CD2 . LEU B 2 214 ? -36.028 -6.772  -15.962 1    31.74  ? 384 LEU B CD2 1 
ATOM   4146 N  N   . GLU B 2 215 ? -40.503 -7.411  -13.144 1    45.29  ? 385 GLU B N   1 
ATOM   4147 C  CA  . GLU B 2 215 ? -41.572 -6.815  -12.352 1    42.8   ? 385 GLU B CA  1 
ATOM   4148 C  C   . GLU B 2 215 ? -41.018 -6.378  -10.991 1    37.05  ? 385 GLU B C   1 
ATOM   4149 O  O   . GLU B 2 215 ? -41.095 -5.22   -10.622 1    37.18  ? 385 GLU B O   1 
ATOM   4150 C  CB  . GLU B 2 215 ? -42.742 -7.786  -12.205 1    44.77  ? 385 GLU B CB  1 
ATOM   4151 C  CG  . GLU B 2 215 ? -44.087 -7.098  -11.999 1    62.44  ? 385 GLU B CG  1 
ATOM   4152 C  CD  . GLU B 2 215 ? -44.801 -6.646  -13.284 1    89.55  ? 385 GLU B CD  1 
ATOM   4153 O  OE1 . GLU B 2 215 ? -44.294 -5.727  -13.982 1    87.59  ? 385 GLU B OE1 1 
ATOM   4154 O  OE2 . GLU B 2 215 ? -45.879 -7.213  -13.621 1    94.65  ? 385 GLU B OE2 1 
ATOM   4155 N  N   . THR B 2 216 ? -40.409 -7.281  -10.238 1    34.76  ? 386 THR B N   1 
ATOM   4156 C  CA  . THR B 2 216 ? -39.947 -6.897  -8.912  1    36.95  ? 386 THR B CA  1 
ATOM   4157 C  C   . THR B 2 216 ? -38.835 -5.828  -8.977  1    37.62  ? 386 THR B C   1 
ATOM   4158 O  O   . THR B 2 216 ? -38.778 -4.934  -8.133  1    39.34  ? 386 THR B O   1 
ATOM   4159 C  CB  . THR B 2 216 ? -39.635 -8.152  -8.084  1    37.7   ? 386 THR B CB  1 
ATOM   4160 O  OG1 . THR B 2 216 ? -38.581 -8.849  -8.723  1    42.54  ? 386 THR B OG1 1 
ATOM   4161 C  CG2 . THR B 2 216 ? -40.796 -9.131  -7.993  1    38.3   ? 386 THR B CG2 1 
ATOM   4162 N  N   . LEU B 2 217 ? -38.012 -5.838  -10.035 1    36.88  ? 387 LEU B N   1 
ATOM   4163 C  CA  . LEU B 2 217 ? -36.917 -4.883  -10.229 1    33.16  ? 387 LEU B CA  1 
ATOM   4164 C  C   . LEU B 2 217 ? -37.328 -3.533  -10.819 1    35.79  ? 387 LEU B C   1 
ATOM   4165 O  O   . LEU B 2 217 ? -36.518 -2.61   -10.804 1    34.18  ? 387 LEU B O   1 
ATOM   4166 C  CB  . LEU B 2 217 ? -35.92  -5.514  -11.195 1    31.67  ? 387 LEU B CB  1 
ATOM   4167 C  CG  . LEU B 2 217 ? -35.317 -6.834  -10.724 1    33.27  ? 387 LEU B CG  1 
ATOM   4168 C  CD1 . LEU B 2 217 ? -34.429 -7.391  -11.826 1    33.08  ? 387 LEU B CD1 1 
ATOM   4169 C  CD2 . LEU B 2 217 ? -34.572 -6.629  -9.396  1    27.89  ? 387 LEU B CD2 1 
ATOM   4170 N  N   . LYS B 2 218 ? -38.534 -3.425  -11.387 1    34.27  ? 388 LYS B N   1 
ATOM   4171 C  CA  . LYS B 2 218 ? -38.959 -2.26   -12.151 1    38.54  ? 388 LYS B CA  1 
ATOM   4172 C  C   . LYS B 2 218 ? -38.71  -0.933  -11.417 1    40.32  ? 388 LYS B C   1 
ATOM   4173 O  O   . LYS B 2 218 ? -38.103 -0.026  -11.994 1    39.77  ? 388 LYS B O   1 
ATOM   4174 C  CB  . LYS B 2 218 ? -40.414 -2.392  -12.632 1    37.78  ? 388 LYS B CB  1 
ATOM   4175 C  CG  . LYS B 2 218 ? -40.941 -1.199  -13.404 1    44.59  ? 388 LYS B CG  1 
ATOM   4176 C  CD  . LYS B 2 218 ? -42.237 -1.378  -14.188 1    54.98  ? 388 LYS B CD  1 
ATOM   4177 C  CE  . LYS B 2 218 ? -42.618 -0.115  -14.922 1    55.78  ? 388 LYS B CE  1 
ATOM   4178 N  NZ  . LYS B 2 218 ? -43.728 -0.252  -15.866 1    52.26  ? 388 LYS B NZ  1 
ATOM   4179 N  N   . PRO B 2 219 ? -39.219 -0.723  -10.176 1    36.74  ? 389 PRO B N   1 
ATOM   4180 C  CA  . PRO B 2 219 ? -39.038 0.563   -9.487  1    35.09  ? 389 PRO B CA  1 
ATOM   4181 C  C   . PRO B 2 219 ? -37.57  1.001   -9.377  1    34.66  ? 389 PRO B C   1 
ATOM   4182 O  O   . PRO B 2 219 ? -37.172 2.113   -9.738  1    33.21  ? 389 PRO B O   1 
ATOM   4183 C  CB  . PRO B 2 219 ? -39.669 0.311   -8.103  1    29.88  ? 389 PRO B CB  1 
ATOM   4184 C  CG  . PRO B 2 219 ? -40.628 -0.829  -8.324  1    28.14  ? 389 PRO B CG  1 
ATOM   4185 C  CD  . PRO B 2 219 ? -39.967 -1.704  -9.375  1    32.22  ? 389 PRO B CD  1 
ATOM   4186 N  N   . CYS B 2 220 ? -36.732 0.098   -8.889  1    33.79  ? 390 CYS B N   1 
ATOM   4187 C  CA  . CYS B 2 220 ? -35.311 0.398   -8.771  1    35.1   ? 390 CYS B CA  1 
ATOM   4188 C  C   . CYS B 2 220 ? -34.707 0.68    -10.151 1    33.23  ? 390 CYS B C   1 
ATOM   4189 O  O   . CYS B 2 220 ? -33.885 1.569   -10.334 1    32.64  ? 390 CYS B O   1 
ATOM   4190 C  CB  . CYS B 2 220 ? -34.636 -0.773  -8.078  1    34.22  ? 390 CYS B CB  1 
ATOM   4191 S  SG  . CYS B 2 220 ? -32.857 -0.574  -7.895  1    37.66  ? 390 CYS B SG  1 
ATOM   4192 N  N   . LEU B 2 221 ? -35.156 -0.081  -11.142 1    31.94  ? 391 LEU B N   1 
ATOM   4193 C  CA  . LEU B 2 221 ? -34.656 0.007   -12.498 1    33.8   ? 391 LEU B CA  1 
ATOM   4194 C  C   . LEU B 2 221 ? -35.034 1.348   -13.138 1    35.17  ? 391 LEU B C   1 
ATOM   4195 O  O   . LEU B 2 221 ? -34.252 1.919   -13.894 1    34.76  ? 391 LEU B O   1 
ATOM   4196 C  CB  . LEU B 2 221 ? -35.293 -1.201  -13.183 1    36.68  ? 391 LEU B CB  1 
ATOM   4197 C  CG  . LEU B 2 221 ? -34.643 -1.692  -14.475 1    44.01  ? 391 LEU B CG  1 
ATOM   4198 C  CD1 . LEU B 2 221 ? -33.12  -1.66   -14.373 1    37.25  ? 391 LEU B CD1 1 
ATOM   4199 C  CD2 . LEU B 2 221 ? -35.15  -3.12   -14.718 1    51.77  ? 391 LEU B CD2 1 
ATOM   4200 N  N   . LEU B 2 222 ? -36.222 1.884   -12.826 1    34.27  ? 392 LEU B N   1 
ATOM   4201 C  CA  . LEU B 2 222 ? -36.592 3.19    -13.349 1    32.44  ? 392 LEU B CA  1 
ATOM   4202 C  C   . LEU B 2 222 ? -35.703 4.285   -12.761 1    32.27  ? 392 LEU B C   1 
ATOM   4203 O  O   . LEU B 2 222 ? -35.353 5.244   -13.448 1    33.44  ? 392 LEU B O   1 
ATOM   4204 C  CB  . LEU B 2 222 ? -38.058 3.454   -13.041 1    29.87  ? 392 LEU B CB  1 
ATOM   4205 C  CG  . LEU B 2 222 ? -39.049 2.646   -13.87  1    32.23  ? 392 LEU B CG  1 
ATOM   4206 C  CD1 . LEU B 2 222 ? -40.465 3.077   -13.529 1    31.77  ? 392 LEU B CD1 1 
ATOM   4207 C  CD2 . LEU B 2 222 ? -38.793 2.81    -15.345 1    30.33  ? 392 LEU B CD2 1 
ATOM   4208 N  N   . ASP B 2 223 ? -35.368 4.146   -11.476 1    29.74  ? 393 ASP B N   1 
ATOM   4209 C  CA  . ASP B 2 223 ? -34.502 5.111   -10.818 1    33.65  ? 393 ASP B CA  1 
ATOM   4210 C  C   . ASP B 2 223 ? -33.082 5.04    -11.388 1    33.74  ? 393 ASP B C   1 
ATOM   4211 O  O   . ASP B 2 223 ? -32.479 6.075   -11.663 1    35.69  ? 393 ASP B O   1 
ATOM   4212 C  CB  . ASP B 2 223 ? -34.495 4.941   -9.304  1    35.1   ? 393 ASP B CB  1 
ATOM   4213 C  CG  . ASP B 2 223 ? -35.712 5.437   -8.541  1    36.16  ? 393 ASP B CG  1 
ATOM   4214 O  OD1 . ASP B 2 223 ? -36.458 6.29    -9.09   1    39.56  ? 393 ASP B OD1 1 
ATOM   4215 O  OD2 . ASP B 2 223 ? -35.926 4.914   -7.42   1    36.7   ? 393 ASP B OD2 1 
ATOM   4216 N  N   . LEU B 2 224 ? -32.537 3.82    -11.521 1    31.43  ? 394 LEU B N   1 
ATOM   4217 C  CA  . LEU B 2 224 ? -31.166 3.617   -11.977 1    31.99  ? 394 LEU B CA  1 
ATOM   4218 C  C   . LEU B 2 224 ? -31.005 4.131   -13.407 1    32.72  ? 394 LEU B C   1 
ATOM   4219 O  O   . LEU B 2 224 ? -29.99  4.695   -13.753 1    36.07  ? 394 LEU B O   1 
ATOM   4220 C  CB  . LEU B 2 224 ? -30.791 2.142   -11.888 1    31.53  ? 394 LEU B CB  1 
ATOM   4221 C  CG  . LEU B 2 224 ? -29.291 1.859   -11.754 1    35.11  ? 394 LEU B CG  1 
ATOM   4222 C  CD1 . LEU B 2 224 ? -28.709 2.603   -10.548 1    35.24  ? 394 LEU B CD1 1 
ATOM   4223 C  CD2 . LEU B 2 224 ? -28.996 0.372   -11.645 1    29.67  ? 394 LEU B CD2 1 
ATOM   4224 N  N   . HIS B 2 225 ? -32.03  3.938   -14.229 1    30.14  ? 395 HIS B N   1 
ATOM   4225 C  CA  . HIS B 2 225 ? -32.037 4.439   -15.58  1    33.14  ? 395 HIS B CA  1 
ATOM   4226 C  C   . HIS B 2 225 ? -31.984 5.971   -15.587 1    34.48  ? 395 HIS B C   1 
ATOM   4227 O  O   . HIS B 2 225 ? -31.364 6.554   -16.471 1    34.56  ? 395 HIS B O   1 
ATOM   4228 C  CB  . HIS B 2 225 ? -33.259 3.857   -16.295 1    31.9   ? 395 HIS B CB  1 
ATOM   4229 C  CG  . HIS B 2 225 ? -33.383 4.269   -17.711 1    31.52  ? 395 HIS B CG  1 
ATOM   4230 N  ND1 . HIS B 2 225 ? -32.305 4.222   -18.561 1    32.66  ? 395 HIS B ND1 1 
ATOM   4231 C  CD2 . HIS B 2 225 ? -34.426 4.717   -18.433 1    33.24  ? 395 HIS B CD2 1 
ATOM   4232 C  CE1 . HIS B 2 225 ? -32.692 4.626   -19.761 1    32.95  ? 395 HIS B CE1 1 
ATOM   4233 N  NE2 . HIS B 2 225 ? -33.973 4.938   -19.704 1    32.91  ? 395 HIS B NE2 1 
ATOM   4234 N  N   . GLN B 2 226 ? -32.655 6.635   -14.635 1    34.54  ? 396 GLN B N   1 
ATOM   4235 C  CA  . GLN B 2 226 ? -32.534 8.081   -14.535 1    35.66  ? 396 GLN B CA  1 
ATOM   4236 C  C   . GLN B 2 226 ? -31.125 8.433   -14.056 1    37.98  ? 396 GLN B C   1 
ATOM   4237 O  O   . GLN B 2 226 ? -30.457 9.303   -14.616 1    41.99  ? 396 GLN B O   1 
ATOM   4238 C  CB  . GLN B 2 226 ? -33.591 8.721   -13.631 1    38.88  ? 396 GLN B CB  1 
ATOM   4239 C  CG  . GLN B 2 226 ? -35.02  8.609   -14.151 1    53.24  ? 396 GLN B CG  1 
ATOM   4240 C  CD  . GLN B 2 226 ? -35.284 9.402   -15.42  1    65.78  ? 396 GLN B CD  1 
ATOM   4241 O  OE1 . GLN B 2 226 ? -35.592 8.844   -16.487 1    55.34  ? 396 GLN B OE1 1 
ATOM   4242 N  NE2 . GLN B 2 226 ? -35.175 10.722  -15.319 1    67.99  ? 396 GLN B NE2 1 
ATOM   4243 N  N   . THR B 2 227 ? -30.654 7.743   -13.017 1    32.21  ? 397 THR B N   1 
ATOM   4244 C  CA  . THR B 2 227 ? -29.355 8.108   -12.504 1    33.78  ? 397 THR B CA  1 
ATOM   4245 C  C   . THR B 2 227 ? -28.35  8.063   -13.66  1    32.74  ? 397 THR B C   1 
ATOM   4246 O  O   . THR B 2 227 ? -27.568 8.988   -13.829 1    33.6   ? 397 THR B O   1 
ATOM   4247 C  CB  . THR B 2 227 ? -29.02  7.226   -11.299 1    33.97  ? 397 THR B CB  1 
ATOM   4248 O  OG1 . THR B 2 227 ? -29.925 7.675   -10.282 1    34.06  ? 397 THR B OG1 1 
ATOM   4249 C  CG2 . THR B 2 227 ? -27.574 7.348   -10.849 1    28.35  ? 397 THR B CG2 1 
ATOM   4250 N  N   . TYR B 2 228 ? -28.464 7.036   -14.504 1    31.79  ? 398 TYR B N   1 
ATOM   4251 C  CA  . TYR B 2 228 ? -27.589 6.801   -15.642 1    31.88  ? 398 TYR B CA  1 
ATOM   4252 C  C   . TYR B 2 228 ? -27.737 7.904   -16.699 1    34.16  ? 398 TYR B C   1 
ATOM   4253 O  O   . TYR B 2 228 ? -26.735 8.426   -17.191 1    34.77  ? 398 TYR B O   1 
ATOM   4254 C  CB  . TYR B 2 228 ? -27.919 5.416   -16.2   1    27.87  ? 398 TYR B CB  1 
ATOM   4255 C  CG  . TYR B 2 228 ? -26.954 4.861   -17.226 1    28.42  ? 398 TYR B CG  1 
ATOM   4256 C  CD1 . TYR B 2 228 ? -25.713 5.456   -17.458 1    29.83  ? 398 TYR B CD1 1 
ATOM   4257 C  CD2 . TYR B 2 228 ? -27.282 3.713   -17.943 1    30.7   ? 398 TYR B CD2 1 
ATOM   4258 C  CE1 . TYR B 2 228 ? -24.828 4.921   -18.387 1    35     ? 398 TYR B CE1 1 
ATOM   4259 C  CE2 . TYR B 2 228 ? -26.397 3.171   -18.866 1    32.75  ? 398 TYR B CE2 1 
ATOM   4260 C  CZ  . TYR B 2 228 ? -25.159 3.764   -19.071 1    33.61  ? 398 TYR B CZ  1 
ATOM   4261 O  OH  . TYR B 2 228 ? -24.289 3.228   -19.965 1    36.72  ? 398 TYR B OH  1 
ATOM   4262 N  N   . LEU B 2 229 ? -28.974 8.288   -17.042 1    31.36  ? 399 LEU B N   1 
ATOM   4263 C  CA  . LEU B 2 229 ? -29.175 9.373   -17.996 1    29.76  ? 399 LEU B CA  1 
ATOM   4264 C  C   . LEU B 2 229 ? -28.57  10.668  -17.473 1    32.63  ? 399 LEU B C   1 
ATOM   4265 O  O   . LEU B 2 229 ? -27.979 11.421  -18.244 1    33.29  ? 399 LEU B O   1 
ATOM   4266 C  CB  . LEU B 2 229 ? -30.647 9.57    -18.332 1    28.08  ? 399 LEU B CB  1 
ATOM   4267 C  CG  . LEU B 2 229 ? -31.278 8.536   -19.28  1    28.35  ? 399 LEU B CG  1 
ATOM   4268 C  CD1 . LEU B 2 229 ? -32.784 8.525   -19.076 1    26.08  ? 399 LEU B CD1 1 
ATOM   4269 C  CD2 . LEU B 2 229 ? -30.953 8.755   -20.763 1    26.12  ? 399 LEU B CD2 1 
ATOM   4270 N  N   . ARG B 2 230 ? -28.702 10.914  -16.163 1    35.03  ? 400 ARG B N   1 
ATOM   4271 C  CA  . ARG B 2 230 ? -28.385 12.225  -15.615 1    41.82  ? 400 ARG B CA  1 
ATOM   4272 C  C   . ARG B 2 230 ? -26.938 12.309  -15.134 1    39.78  ? 400 ARG B C   1 
ATOM   4273 O  O   . ARG B 2 230 ? -26.518 13.366  -14.664 1    40.2   ? 400 ARG B O   1 
ATOM   4274 C  CB  . ARG B 2 230 ? -29.354 12.578  -14.484 1    49.89  ? 400 ARG B CB  1 
ATOM   4275 C  CG  . ARG B 2 230 ? -30.754 12.955  -14.954 1    61.4   ? 400 ARG B CG  1 
ATOM   4276 C  CD  . ARG B 2 230 ? -31.676 13.142  -13.755 1    71.1   ? 400 ARG B CD  1 
ATOM   4277 N  NE  . ARG B 2 230 ? -33.003 13.669  -14.103 1    81.53  ? 400 ARG B NE  1 
ATOM   4278 C  CZ  . ARG B 2 230 ? -34.171 13.29   -13.577 1    77.57  ? 400 ARG B CZ  1 
ATOM   4279 N  NH1 . ARG B 2 230 ? -34.228 12.285  -12.698 1    66.35  ? 400 ARG B NH1 1 
ATOM   4280 N  NH2 . ARG B 2 230 ? -35.267 13.938  -13.957 1    57.14  ? 400 ARG B NH2 1 
ATOM   4281 N  N   . ALA B 2 231 ? -26.177 11.215  -15.273 1    34.29  ? 401 ALA B N   1 
ATOM   4282 C  CA  . ALA B 2 231 ? -24.883 11.106  -14.611 1    35.59  ? 401 ALA B CA  1 
ATOM   4283 C  C   . ALA B 2 231 ? -23.889 12.143  -15.152 1    35.18  ? 401 ALA B C   1 
ATOM   4284 O  O   . ALA B 2 231 ? -23.057 12.663  -14.408 1    36.88  ? 401 ALA B O   1 
ATOM   4285 C  CB  . ALA B 2 231 ? -24.351 9.683   -14.695 1    28.26  ? 401 ALA B CB  1 
ATOM   4286 N  N   . PRO B 2 232 ? -23.886 12.47   -16.459 1    32.85  ? 402 PRO B N   1 
ATOM   4287 C  CA  . PRO B 2 232 ? -23.023 13.549  -16.929 1    36.6   ? 402 PRO B CA  1 
ATOM   4288 C  C   . PRO B 2 232 ? -23.241 14.877  -16.197 1    37.05  ? 402 PRO B C   1 
ATOM   4289 O  O   . PRO B 2 232 ? -22.325 15.696  -16.17  1    38.51  ? 402 PRO B O   1 
ATOM   4290 C  CB  . PRO B 2 232 ? -23.383 13.636  -18.424 1    28.83  ? 402 PRO B CB  1 
ATOM   4291 C  CG  . PRO B 2 232 ? -23.816 12.244  -18.765 1    27.52  ? 402 PRO B CG  1 
ATOM   4292 C  CD  . PRO B 2 232 ? -24.63  11.821  -17.551 1    30.17  ? 402 PRO B CD  1 
ATOM   4293 N  N   . GLN B 2 233 ? -24.432 15.071  -15.604 1    33.7   ? 403 GLN B N   1 
ATOM   4294 C  CA  . GLN B 2 233 ? -24.783 16.336  -14.975 1    35.24  ? 403 GLN B CA  1 
ATOM   4295 C  C   . GLN B 2 233 ? -24.637 16.312  -13.457 1    36.65  ? 403 GLN B C   1 
ATOM   4296 O  O   . GLN B 2 233 ? -24.548 17.385  -12.872 1    37.95  ? 403 GLN B O   1 
ATOM   4297 C  CB  . GLN B 2 233 ? -26.218 16.776  -15.246 1    40.98  ? 403 GLN B CB  1 
ATOM   4298 C  CG  . GLN B 2 233 ? -26.361 17.611  -16.509 1    52.55  ? 403 GLN B CG  1 
ATOM   4299 C  CD  . GLN B 2 233 ? -26.203 16.766  -17.747 1    61.15  ? 403 GLN B CD  1 
ATOM   4300 O  OE1 . GLN B 2 233 ? -25.326 17.001  -18.59  1    65.38  ? 403 GLN B OE1 1 
ATOM   4301 N  NE2 . GLN B 2 233 ? -27.062 15.758  -17.847 1    62.54  ? 403 GLN B NE2 1 
ATOM   4302 N  N   . HIS B 2 234 ? -24.622 15.124  -12.819 1    34.72  ? 404 HIS B N   1 
ATOM   4303 C  CA  . HIS B 2 234 ? -24.53  15.053  -11.364 1    31.48  ? 404 HIS B CA  1 
ATOM   4304 C  C   . HIS B 2 234 ? -23.379 15.936  -10.869 1    30.86  ? 404 HIS B C   1 
ATOM   4305 O  O   . HIS B 2 234 ? -22.345 16.051  -11.525 1    29.82  ? 404 HIS B O   1 
ATOM   4306 C  CB  . HIS B 2 234 ? -24.363 13.604  -10.912 1    30.53  ? 404 HIS B CB  1 
ATOM   4307 C  CG  . HIS B 2 234 ? -24.698 13.315  -9.483  1    35.3   ? 404 HIS B CG  1 
ATOM   4308 N  ND1 . HIS B 2 234 ? -23.945 13.739  -8.404  1    40.34  ? 404 HIS B ND1 1 
ATOM   4309 C  CD2 . HIS B 2 234 ? -25.704 12.586  -8.959  1    34.05  ? 404 HIS B CD2 1 
ATOM   4310 C  CE1 . HIS B 2 234 ? -24.503 13.298  -7.27   1    36.98  ? 404 HIS B CE1 1 
ATOM   4311 N  NE2 . HIS B 2 234 ? -25.566 12.594  -7.581  1    33.32  ? 404 HIS B NE2 1 
ATOM   4312 N  N   . ALA B 2 235 ? -23.575 16.577  -9.719  1    27.82  ? 405 ALA B N   1 
ATOM   4313 C  CA  . ALA B 2 235 ? -22.53  17.358  -9.063  1    29.47  ? 405 ALA B CA  1 
ATOM   4314 C  C   . ALA B 2 235 ? -21.259 16.53   -8.791  1    30.29  ? 405 ALA B C   1 
ATOM   4315 O  O   . ALA B 2 235 ? -20.153 17.077  -8.802  1    26.68  ? 405 ALA B O   1 
ATOM   4316 C  CB  . ALA B 2 235 ? -23.081 17.928  -7.761  1    26.24  ? 405 ALA B CB  1 
ATOM   4317 N  N   . GLN B 2 236 ? -21.42  15.227  -8.486  1    27.4   ? 406 GLN B N   1 
ATOM   4318 C  CA  . GLN B 2 236 ? -20.295 14.356  -8.191  1    29.31  ? 406 GLN B CA  1 
ATOM   4319 C  C   . GLN B 2 236 ? -19.902 13.594  -9.447  1    30.18  ? 406 GLN B C   1 
ATOM   4320 O  O   . GLN B 2 236 ? -20.751 12.953  -10.05  1    36.08  ? 406 GLN B O   1 
ATOM   4321 C  CB  . GLN B 2 236 ? -20.691 13.362  -7.101  1    30.28  ? 406 GLN B CB  1 
ATOM   4322 C  CG  . GLN B 2 236 ? -20.601 13.921  -5.684  1    32.18  ? 406 GLN B CG  1 
ATOM   4323 C  CD  . GLN B 2 236 ? -21.391 15.195  -5.482  1    36.94  ? 406 GLN B CD  1 
ATOM   4324 O  OE1 . GLN B 2 236 ? -22.616 15.236  -5.616  1    43.15  ? 406 GLN B OE1 1 
ATOM   4325 N  NE2 . GLN B 2 236 ? -20.688 16.264  -5.156  1    34.32  ? 406 GLN B NE2 1 
ATOM   4326 N  N   . GLN B 2 237 ? -18.617 13.62   -9.815  1    29.83  ? 407 GLN B N   1 
ATOM   4327 C  CA  . GLN B 2 237 ? -18.191 13.053  -11.088 1    29.25  ? 407 GLN B CA  1 
ATOM   4328 C  C   . GLN B 2 237 ? -17.054 12.041  -10.957 1    32.16  ? 407 GLN B C   1 
ATOM   4329 O  O   . GLN B 2 237 ? -16.585 11.536  -11.978 1    36.3   ? 407 GLN B O   1 
ATOM   4330 C  CB  . GLN B 2 237 ? -17.769 14.168  -12.035 1    25.99  ? 407 GLN B CB  1 
ATOM   4331 C  CG  . GLN B 2 237 ? -18.926 14.993  -12.585 1    26.48  ? 407 GLN B CG  1 
ATOM   4332 C  CD  . GLN B 2 237 ? -19.792 14.241  -13.57  1    28.87  ? 407 GLN B CD  1 
ATOM   4333 O  OE1 . GLN B 2 237 ? -19.298 13.568  -14.465 1    34.04  ? 407 GLN B OE1 1 
ATOM   4334 N  NE2 . GLN B 2 237 ? -21.1   14.321  -13.428 1    29.97  ? 407 GLN B NE2 1 
ATOM   4335 N  N   . SER B 2 238 ? -16.662 11.688  -9.726  1    30.16  ? 408 SER B N   1 
ATOM   4336 C  CA  . SER B 2 238 ? -15.474 10.877  -9.509  1    33.36  ? 408 SER B CA  1 
ATOM   4337 C  C   . SER B 2 238 ? -15.62  9.468   -10.092 1    34.3   ? 408 SER B C   1 
ATOM   4338 O  O   . SER B 2 238 ? -14.641 8.89    -10.577 1    36.94  ? 408 SER B O   1 
ATOM   4339 C  CB  . SER B 2 238 ? -15.087 10.829  -8.042  1    32.41  ? 408 SER B CB  1 
ATOM   4340 O  OG  . SER B 2 238 ? -14.538 12.086  -7.658  1    33.5   ? 408 SER B OG  1 
ATOM   4341 N  N   . ILE B 2 239 ? -16.821 8.897   -10.01  1    29.03  ? 409 ILE B N   1 
ATOM   4342 C  CA  . ILE B 2 239 ? -17.036 7.55    -10.515 1    29.11  ? 409 ILE B CA  1 
ATOM   4343 C  C   . ILE B 2 239 ? -16.946 7.53    -12.051 1    31.88  ? 409 ILE B C   1 
ATOM   4344 O  O   . ILE B 2 239 ? -16.344 6.62    -12.637 1    27.06  ? 409 ILE B O   1 
ATOM   4345 C  CB  . ILE B 2 239 ? -18.374 6.991   -10     1    29.9   ? 409 ILE B CB  1 
ATOM   4346 C  CG1 . ILE B 2 239 ? -18.353 6.722   -8.506  1    30.4   ? 409 ILE B CG1 1 
ATOM   4347 C  CG2 . ILE B 2 239 ? -18.756 5.737   -10.767 1    27.71  ? 409 ILE B CG2 1 
ATOM   4348 C  CD1 . ILE B 2 239 ? -19.716 6.369   -7.955  1    27.83  ? 409 ILE B CD1 1 
ATOM   4349 N  N   . ARG B 2 240 ? -17.541 8.536   -12.711 1    29.77  ? 410 ARG B N   1 
ATOM   4350 C  CA  . ARG B 2 240 ? -17.474 8.581   -14.158 1    30.69  ? 410 ARG B CA  1 
ATOM   4351 C  C   . ARG B 2 240 ? -16.022 8.655   -14.626 1    33.59  ? 410 ARG B C   1 
ATOM   4352 O  O   . ARG B 2 240 ? -15.673 7.993   -15.61  1    32.42  ? 410 ARG B O   1 
ATOM   4353 C  CB  . ARG B 2 240 ? -18.286 9.747   -14.721 1    32.4   ? 410 ARG B CB  1 
ATOM   4354 C  CG  . ARG B 2 240 ? -19.77  9.45    -14.847 1    31.1   ? 410 ARG B CG  1 
ATOM   4355 C  CD  . ARG B 2 240 ? -20.501 10.584  -15.519 1    27.03  ? 410 ARG B CD  1 
ATOM   4356 N  NE  . ARG B 2 240 ? -20.335 10.499  -16.967 1    26.81  ? 410 ARG B NE  1 
ATOM   4357 C  CZ  . ARG B 2 240 ? -19.904 11.477  -17.739 1    25.86  ? 410 ARG B CZ  1 
ATOM   4358 N  NH1 . ARG B 2 240 ? -19.88  11.296  -19.033 1    23.9   ? 410 ARG B NH1 1 
ATOM   4359 N  NH2 . ARG B 2 240 ? -19.509 12.621  -17.233 1    24.65  ? 410 ARG B NH2 1 
ATOM   4360 N  N   . GLU B 2 241 ? -15.202 9.472   -13.933 1    35.84  ? 411 GLU B N   1 
ATOM   4361 C  CA  . GLU B 2 241 ? -13.777 9.65    -14.241 1    35.43  ? 411 GLU B CA  1 
ATOM   4362 C  C   . GLU B 2 241 ? -13.055 8.318   -14.069 1    32.94  ? 411 GLU B C   1 
ATOM   4363 O  O   . GLU B 2 241 ? -12.277 7.917   -14.928 1    32.35  ? 411 GLU B O   1 
ATOM   4364 C  CB  . GLU B 2 241 ? -13.037 10.64   -13.332 1    36.7   ? 411 GLU B CB  1 
ATOM   4365 C  CG  . GLU B 2 241 ? -13.665 12.031  -13.257 1    46.46  ? 411 GLU B CG  1 
ATOM   4366 C  CD  . GLU B 2 241 ? -13.556 12.905  -14.499 1    56.61  ? 411 GLU B CD  1 
ATOM   4367 O  OE1 . GLU B 2 241 ? -12.723 12.594  -15.391 1    59.39  ? 411 GLU B OE1 1 
ATOM   4368 O  OE2 . GLU B 2 241 ? -14.31  13.908  -14.571 1    57.15  ? 411 GLU B OE2 1 
ATOM   4369 N  N   . LYS B 2 242 ? -13.323 7.652   -12.938 1    29.95  ? 412 LYS B N   1 
ATOM   4370 C  CA  . LYS B 2 242 ? -12.764 6.354   -12.647 1    29.71  ? 412 LYS B CA  1 
ATOM   4371 C  C   . LYS B 2 242 ? -13.118 5.364   -13.757 1    35.11  ? 412 LYS B C   1 
ATOM   4372 O  O   . LYS B 2 242 ? -12.267 4.584   -14.182 1    42.61  ? 412 LYS B O   1 
ATOM   4373 C  CB  . LYS B 2 242 ? -13.299 5.866   -11.298 1    26.41  ? 412 LYS B CB  1 
ATOM   4374 C  CG  . LYS B 2 242 ? -13.037 4.405   -10.971 1    23.38  ? 412 LYS B CG  1 
ATOM   4375 C  CD  . LYS B 2 242 ? -13.42  4.103   -9.523  1    26.05  ? 412 LYS B CD  1 
ATOM   4376 C  CE  . LYS B 2 242 ? -13.515 2.65    -9.134  1    22.28  ? 412 LYS B CE  1 
ATOM   4377 N  NZ  . LYS B 2 242 ? -14.101 2.495   -7.805  1    21.98  ? 412 LYS B NZ  1 
ATOM   4378 N  N   . TYR B 2 243 ? -14.375 5.367   -14.2   1    29.73  ? 413 TYR B N   1 
ATOM   4379 C  CA  . TYR B 2 243 ? -14.795 4.368   -15.158 1    31.2   ? 413 TYR B CA  1 
ATOM   4380 C  C   . TYR B 2 243 ? -14.504 4.781   -16.611 1    33.28  ? 413 TYR B C   1 
ATOM   4381 O  O   . TYR B 2 243 ? -14.915 4.051   -17.523 1    34.65  ? 413 TYR B O   1 
ATOM   4382 C  CB  . TYR B 2 243 ? -16.239 3.936   -14.894 1    29.66  ? 413 TYR B CB  1 
ATOM   4383 C  CG  . TYR B 2 243 ? -16.36  2.961   -13.738 1    32.82  ? 413 TYR B CG  1 
ATOM   4384 C  CD1 . TYR B 2 243 ? -16.296 3.416   -12.417 1    36.29  ? 413 TYR B CD1 1 
ATOM   4385 C  CD2 . TYR B 2 243 ? -16.537 1.593   -13.954 1    29.68  ? 413 TYR B CD2 1 
ATOM   4386 C  CE1 . TYR B 2 243 ? -16.402 2.546   -11.337 1    33.04  ? 413 TYR B CE1 1 
ATOM   4387 C  CE2 . TYR B 2 243 ? -16.643 0.713   -12.884 1    30.85  ? 413 TYR B CE2 1 
ATOM   4388 C  CZ  . TYR B 2 243 ? -16.572 1.188   -11.57  1    36.95  ? 413 TYR B CZ  1 
ATOM   4389 O  OH  . TYR B 2 243 ? -16.642 0.361   -10.471 1    37.4   ? 413 TYR B OH  1 
ATOM   4390 N  N   . LYS B 2 244 ? -13.766 5.883   -16.841 1    30.52  ? 414 LYS B N   1 
ATOM   4391 C  CA  . LYS B 2 244 ? -13.151 6.145   -18.141 1    35.71  ? 414 LYS B CA  1 
ATOM   4392 C  C   . LYS B 2 244 ? -11.92  5.255   -18.378 1    39.59  ? 414 LYS B C   1 
ATOM   4393 O  O   . LYS B 2 244 ? -11.499 5.025   -19.522 1    42.72  ? 414 LYS B O   1 
ATOM   4394 C  CB  . LYS B 2 244 ? -12.664 7.593   -18.285 1    35.75  ? 414 LYS B CB  1 
ATOM   4395 C  CG  . LYS B 2 244 ? -13.741 8.634   -18.437 1    39.47  ? 414 LYS B CG  1 
ATOM   4396 C  CD  . LYS B 2 244 ? -13.205 10.061  -18.356 1    39.81  ? 414 LYS B CD  1 
ATOM   4397 C  CE  . LYS B 2 244 ? -14.354 11.041  -18.145 1    44.56  ? 414 LYS B CE  1 
ATOM   4398 N  NZ  . LYS B 2 244 ? -13.835 12.418  -18.13  1    47.75  ? 414 LYS B NZ  1 
ATOM   4399 N  N   . ASN B 2 245 ? -11.306 4.796   -17.281 1    38.99  ? 415 ASN B N   1 
ATOM   4400 C  CA  . ASN B 2 245 ? -10.05  4.07    -17.32  1    39     ? 415 ASN B CA  1 
ATOM   4401 C  C   . ASN B 2 245 ? -10.247 2.734   -18.03  1    42.44  ? 415 ASN B C   1 
ATOM   4402 O  O   . ASN B 2 245 ? -11.318 2.119   -17.929 1    43.34  ? 415 ASN B O   1 
ATOM   4403 C  CB  . ASN B 2 245 ? -9.526  3.883   -15.903 1    42.9   ? 415 ASN B CB  1 
ATOM   4404 C  CG  . ASN B 2 245 ? -8.135  3.298   -15.862 1    52.71  ? 415 ASN B CG  1 
ATOM   4405 O  OD1 . ASN B 2 245 ? -7.96   2.071   -15.948 1    51.94  ? 415 ASN B OD1 1 
ATOM   4406 N  ND2 . ASN B 2 245 ? -7.137  4.164   -15.706 1    54.78  ? 415 ASN B ND2 1 
ATOM   4407 N  N   . SER B 2 246 ? -9.183  2.286   -18.714 1    37.86  ? 416 SER B N   1 
ATOM   4408 C  CA  . SER B 2 246 ? -9.176  1.016   -19.428 1    40.3   ? 416 SER B CA  1 
ATOM   4409 C  C   . SER B 2 246 ? -9.481  -0.159  -18.494 1    36.89  ? 416 SER B C   1 
ATOM   4410 O  O   . SER B 2 246 ? -10.178 -1.093  -18.878 1    41.77  ? 416 SER B O   1 
ATOM   4411 C  CB  . SER B 2 246 ? -7.888  0.806   -20.145 1    36.13  ? 416 SER B CB  1 
ATOM   4412 O  OG  . SER B 2 246 ? -6.862  0.823   -19.16  1    51.39  ? 416 SER B OG  1 
ATOM   4413 N  N   . LYS B 2 247 ? -8.938  -0.123  -17.282 1    33.15  ? 417 LYS B N   1 
ATOM   4414 C  CA  . LYS B 2 247 ? -9.166  -1.159  -16.29  1    37.11  ? 417 LYS B CA  1 
ATOM   4415 C  C   . LYS B 2 247 ? -10.638 -1.551  -16.269 1    38.78  ? 417 LYS B C   1 
ATOM   4416 O  O   . LYS B 2 247 ? -10.945 -2.722  -16.077 1    42.12  ? 417 LYS B O   1 
ATOM   4417 C  CB  . LYS B 2 247 ? -8.785  -0.587  -14.922 1    37.7   ? 417 LYS B CB  1 
ATOM   4418 C  CG  . LYS B 2 247 ? -8.643  -1.578  -13.805 1    40.84  ? 417 LYS B CG  1 
ATOM   4419 C  CD  . LYS B 2 247 ? -8.097  -0.886  -12.557 1    58.24  ? 417 LYS B CD  1 
ATOM   4420 C  CE  . LYS B 2 247 ? -7.585  -1.829  -11.513 1    66.58  ? 417 LYS B CE  1 
ATOM   4421 N  NZ  . LYS B 2 247 ? -8.707  -2.743  -11.279 1    69.34  ? 417 LYS B NZ  1 
ATOM   4422 N  N   . TYR B 2 248 ? -11.527 -0.575  -16.511 1    36.11  ? 418 TYR B N   1 
ATOM   4423 C  CA  . TYR B 2 248 ? -12.973 -0.773  -16.446 1    35.46  ? 418 TYR B CA  1 
ATOM   4424 C  C   . TYR B 2 248 ? -13.585 -0.643  -17.839 1    32     ? 418 TYR B C   1 
ATOM   4425 O  O   . TYR B 2 248 ? -14.76  -0.339  -17.961 1    34.26  ? 418 TYR B O   1 
ATOM   4426 C  CB  . TYR B 2 248 ? -13.585 0.236   -15.458 1    33.68  ? 418 TYR B CB  1 
ATOM   4427 C  CG  . TYR B 2 248 ? -13.01  0.15    -14.046 1    36.93  ? 418 TYR B CG  1 
ATOM   4428 C  CD1 . TYR B 2 248 ? -13.282 -0.958  -13.244 1    36.48  ? 418 TYR B CD1 1 
ATOM   4429 C  CD2 . TYR B 2 248 ? -12.177 1.142   -13.535 1    32.4   ? 418 TYR B CD2 1 
ATOM   4430 C  CE1 . TYR B 2 248 ? -12.775 -1.072  -11.959 1    39.98  ? 418 TYR B CE1 1 
ATOM   4431 C  CE2 . TYR B 2 248 ? -11.639 1.021   -12.262 1    41.91  ? 418 TYR B CE2 1 
ATOM   4432 C  CZ  . TYR B 2 248 ? -11.937 -0.085  -11.464 1    47.52  ? 418 TYR B CZ  1 
ATOM   4433 O  OH  . TYR B 2 248 ? -11.409 -0.223  -10.193 1    51.48  ? 418 TYR B OH  1 
ATOM   4434 N  N   . HIS B 2 249 ? -12.767 -0.818  -18.878 1    28.73  ? 419 HIS B N   1 
ATOM   4435 C  CA  . HIS B 2 249 ? -13.207 -0.897  -20.268 1    28.75  ? 419 HIS B CA  1 
ATOM   4436 C  C   . HIS B 2 249 ? -13.843 0.4     -20.748 1    30.59  ? 419 HIS B C   1 
ATOM   4437 O  O   . HIS B 2 249 ? -14.614 0.377   -21.703 1    28.51  ? 419 HIS B O   1 
ATOM   4438 C  CB  . HIS B 2 249 ? -14.098 -2.117  -20.533 1    28.53  ? 419 HIS B CB  1 
ATOM   4439 C  CG  . HIS B 2 249 ? -13.468 -3.345  -19.968 1    39.25  ? 419 HIS B CG  1 
ATOM   4440 N  ND1 . HIS B 2 249 ? -13.605 -3.742  -18.637 1    39.23  ? 419 HIS B ND1 1 
ATOM   4441 C  CD2 . HIS B 2 249 ? -12.606 -4.217  -20.559 1    32.92  ? 419 HIS B CD2 1 
ATOM   4442 C  CE1 . HIS B 2 249 ? -12.864 -4.838  -18.44  1    39.33  ? 419 HIS B CE1 1 
ATOM   4443 N  NE2 . HIS B 2 249 ? -12.243 -5.138  -19.595 1    38.23  ? 419 HIS B NE2 1 
ATOM   4444 N  N   . GLY B 2 250 ? -13.513 1.517   -20.087 1    30.92  ? 420 GLY B N   1 
ATOM   4445 C  CA  . GLY B 2 250 ? -14.056 2.814   -20.464 1    34.31  ? 420 GLY B CA  1 
ATOM   4446 C  C   . GLY B 2 250 ? -15.593 2.877   -20.461 1    34.12  ? 420 GLY B C   1 
ATOM   4447 O  O   . GLY B 2 250 ? -16.182 3.665   -21.204 1    30.65  ? 420 GLY B O   1 
ATOM   4448 N  N   . VAL B 2 251 ? -16.249 2.121   -19.574 1    28.88  ? 421 VAL B N   1 
ATOM   4449 C  CA  . VAL B 2 251 ? -17.681 1.97    -19.731 1    28.3   ? 421 VAL B CA  1 
ATOM   4450 C  C   . VAL B 2 251 ? -18.447 3.271   -19.499 1    31.17  ? 421 VAL B C   1 
ATOM   4451 O  O   . VAL B 2 251 ? -19.545 3.41    -20.025 1    33.91  ? 421 VAL B O   1 
ATOM   4452 C  CB  . VAL B 2 251 ? -18.257 0.844   -18.875 1    28.8   ? 421 VAL B CB  1 
ATOM   4453 C  CG1 . VAL B 2 251 ? -17.737 -0.495  -19.368 1    28.26  ? 421 VAL B CG1 1 
ATOM   4454 C  CG2 . VAL B 2 251 ? -17.999 1.076   -17.391 1    29.44  ? 421 VAL B CG2 1 
ATOM   4455 N  N   . SER B 2 252 ? -17.89  4.235   -18.752 1    32.59  ? 422 SER B N   1 
ATOM   4456 C  CA  . SER B 2 252 ? -18.638 5.468   -18.495 1    29.88  ? 422 SER B CA  1 
ATOM   4457 C  C   . SER B 2 252 ? -18.792 6.273   -19.777 1    31.3   ? 422 SER B C   1 
ATOM   4458 O  O   . SER B 2 252 ? -19.47  7.293   -19.777 1    32.91  ? 422 SER B O   1 
ATOM   4459 C  CB  . SER B 2 252 ? -18.083 6.315   -17.372 1    26.19  ? 422 SER B CB  1 
ATOM   4460 O  OG  . SER B 2 252 ? -16.751 6.721   -17.622 1    29.23  ? 422 SER B OG  1 
ATOM   4461 N  N   . LEU B 2 253 ? -18.148 5.819   -20.857 1    32.04  ? 423 LEU B N   1 
ATOM   4462 C  CA  . LEU B 2 253 ? -18.216 6.53    -22.125 1    34.49  ? 423 LEU B CA  1 
ATOM   4463 C  C   . LEU B 2 253 ? -19.362 5.984   -22.984 1    37.41  ? 423 LEU B C   1 
ATOM   4464 O  O   . LEU B 2 253 ? -19.826 6.684   -23.886 1    38.17  ? 423 LEU B O   1 
ATOM   4465 C  CB  . LEU B 2 253 ? -16.868 6.473   -22.845 1    32.18  ? 423 LEU B CB  1 
ATOM   4466 C  CG  . LEU B 2 253 ? -15.684 7.148   -22.136 1    32.55  ? 423 LEU B CG  1 
ATOM   4467 C  CD1 . LEU B 2 253 ? -14.434 6.825   -22.932 1    35.84  ? 423 LEU B CD1 1 
ATOM   4468 C  CD2 . LEU B 2 253 ? -15.835 8.666   -22.022 1    34.76  ? 423 LEU B CD2 1 
ATOM   4469 N  N   . LEU B 2 254 ? -19.827 4.753   -22.69  1    33.1   ? 424 LEU B N   1 
ATOM   4470 C  CA  . LEU B 2 254 ? -20.959 4.152   -23.383 1    31.63  ? 424 LEU B CA  1 
ATOM   4471 C  C   . LEU B 2 254 ? -22.184 5.042   -23.213 1    37.11  ? 424 LEU B C   1 
ATOM   4472 O  O   . LEU B 2 254 ? -22.37  5.628   -22.148 1    40.65  ? 424 LEU B O   1 
ATOM   4473 C  CB  . LEU B 2 254 ? -21.242 2.77    -22.799 1    29.08  ? 424 LEU B CB  1 
ATOM   4474 C  CG  . LEU B 2 254 ? -20.208 1.69    -23.128 1    29.44  ? 424 LEU B CG  1 
ATOM   4475 C  CD1 . LEU B 2 254 ? -20.502 0.417   -22.367 1    23.12  ? 424 LEU B CD1 1 
ATOM   4476 C  CD2 . LEU B 2 254 ? -20.114 1.438   -24.656 1    24.9   ? 424 LEU B CD2 1 
ATOM   4477 N  N   . ASN B 2 255 ? -23.018 5.138   -24.263 1    35.44  ? 425 ASN B N   1 
ATOM   4478 C  CA  . ASN B 2 255 ? -24.222 5.943   -24.164 1    36.21  ? 425 ASN B CA  1 
ATOM   4479 C  C   . ASN B 2 255 ? -25.336 5.136   -23.506 1    35.65  ? 425 ASN B C   1 
ATOM   4480 O  O   . ASN B 2 255 ? -25.59  4.012   -23.934 1    37.65  ? 425 ASN B O   1 
ATOM   4481 C  CB  . ASN B 2 255 ? -24.715 6.428   -25.519 1    36.69  ? 425 ASN B CB  1 
ATOM   4482 C  CG  . ASN B 2 255 ? -23.85  7.512   -26.105 1    41.46  ? 425 ASN B CG  1 
ATOM   4483 O  OD1 . ASN B 2 255 ? -23.704 7.567   -27.325 1    48.64  ? 425 ASN B OD1 1 
ATOM   4484 N  ND2 . ASN B 2 255 ? -23.333 8.419   -25.284 1    46.36  ? 425 ASN B ND2 1 
ATOM   4485 N  N   . PRO B 2 256 ? -26.058 5.702   -22.505 1    33.2   ? 426 PRO B N   1 
ATOM   4486 C  CA  . PRO B 2 256 ? -27.21  5.019   -21.912 1    33.25  ? 426 PRO B CA  1 
ATOM   4487 C  C   . PRO B 2 256 ? -28.321 4.914   -22.958 1    37.61  ? 426 PRO B C   1 
ATOM   4488 O  O   . PRO B 2 256 ? -28.43  5.773   -23.838 1    34.55  ? 426 PRO B O   1 
ATOM   4489 C  CB  . PRO B 2 256 ? -27.62  5.927   -20.759 1    27.88  ? 426 PRO B CB  1 
ATOM   4490 C  CG  . PRO B 2 256 ? -27.181 7.303   -21.212 1    28.65  ? 426 PRO B CG  1 
ATOM   4491 C  CD  . PRO B 2 256 ? -25.863 7.054   -21.95  1    30.49  ? 426 PRO B CD  1 
ATOM   4492 N  N   . PRO B 2 257 ? -29.205 3.891   -22.857 1    36.98  ? 427 PRO B N   1 
ATOM   4493 C  CA  . PRO B 2 257 ? -30.314 3.75    -23.806 1    30.81  ? 427 PRO B CA  1 
ATOM   4494 C  C   . PRO B 2 257 ? -31.363 4.783   -23.42  1    30.4   ? 427 PRO B C   1 
ATOM   4495 O  O   . PRO B 2 257 ? -31.455 5.13    -22.25  1    29.25  ? 427 PRO B O   1 
ATOM   4496 C  CB  . PRO B 2 257 ? -30.791 2.314   -23.532 1    36.92  ? 427 PRO B CB  1 
ATOM   4497 C  CG  . PRO B 2 257 ? -30.466 2.07    -22.049 1    31.44  ? 427 PRO B CG  1 
ATOM   4498 C  CD  . PRO B 2 257 ? -29.202 2.875   -21.778 1    31.84  ? 427 PRO B CD  1 
ATOM   4499 N  N   . GLU B 2 258 ? -32.129 5.281   -24.398 1    35.38  ? 428 GLU B N   1 
ATOM   4500 C  CA  . GLU B 2 258 ? -33.148 6.271   -24.094 1    39.26  ? 428 GLU B CA  1 
ATOM   4501 C  C   . GLU B 2 258 ? -34.349 5.623   -23.399 1    39.52  ? 428 GLU B C   1 
ATOM   4502 O  O   . GLU B 2 258 ? -35.025 6.318   -22.649 1    42.6   ? 428 GLU B O   1 
ATOM   4503 C  CB  . GLU B 2 258 ? -33.759 6.911   -25.331 1    47.02  ? 428 GLU B CB  1 
ATOM   4504 C  CG  . GLU B 2 258 ? -32.829 7.636   -26.304 1    64.19  ? 428 GLU B CG  1 
ATOM   4505 C  CD  . GLU B 2 258 ? -33.636 7.99    -27.567 1    82.09  ? 428 GLU B CD  1 
ATOM   4506 O  OE1 . GLU B 2 258 ? -34.885 7.771   -27.607 1    73.46  ? 428 GLU B OE1 1 
ATOM   4507 O  OE2 . GLU B 2 258 ? -33.022 8.483   -28.551 1    98.01  ? 428 GLU B OE2 1 
ATOM   4508 N  N   . THR B 2 259 ? -34.635 4.334   -23.692 1    36.15  ? 429 THR B N   1 
ATOM   4509 C  CA  . THR B 2 259 ? -35.823 3.622   -23.217 1    39.71  ? 429 THR B CA  1 
ATOM   4510 C  C   . THR B 2 259 ? -35.457 2.204   -22.783 1    42.3   ? 429 THR B C   1 
ATOM   4511 O  O   . THR B 2 259 ? -34.442 1.676   -23.23  1    44.51  ? 429 THR B O   1 
ATOM   4512 C  CB  . THR B 2 259 ? -36.944 3.535   -24.267 1    35.48  ? 429 THR B CB  1 
ATOM   4513 O  OG1 . THR B 2 259 ? -36.592 2.575   -25.261 1    31.9   ? 429 THR B OG1 1 
ATOM   4514 C  CG2 . THR B 2 259 ? -37.356 4.873   -24.858 1    32.07  ? 429 THR B CG2 1 
ATOM   4515 N  N   . LEU B 2 260 ? -36.34  1.562   -21.993 1    42.07  ? 430 LEU B N   1 
ATOM   4516 C  CA  . LEU B 2 260 ? -36.077 0.23    -21.465 1    48.76  ? 430 LEU B CA  1 
ATOM   4517 C  C   . LEU B 2 260 ? -37     -0.839  -22.061 1    59.94  ? 430 LEU B C   1 
ATOM   4518 O  O   . LEU B 2 260 ? -36.651 -2.03   -22.027 1    57.15  ? 430 LEU B O   1 
ATOM   4519 C  CB  . LEU B 2 260 ? -36.201 0.234   -19.944 1    45.16  ? 430 LEU B CB  1 
ATOM   4520 C  CG  . LEU B 2 260 ? -35.207 1.083   -19.155 1    42.83  ? 430 LEU B CG  1 
ATOM   4521 C  CD1 . LEU B 2 260 ? -35.444 0.833   -17.662 1    40.9   ? 430 LEU B CD1 1 
ATOM   4522 C  CD2 . LEU B 2 260 ? -33.787 0.772   -19.573 1    39.96  ? 430 LEU B CD2 1 
ATOM   4523 N  N   . ASN B 2 261 ? -38.184 -0.421  -22.554 1    67.17  ? 431 ASN B N   1 
ATOM   4524 C  CA  . ASN B 2 261 ? -39.247 -1.329  -22.983 1    71.36  ? 431 ASN B CA  1 
ATOM   4525 C  C   . ASN B 2 261 ? -39.626 -2.258  -21.828 1    65.46  ? 431 ASN B C   1 
ATOM   4526 O  O   . ASN B 2 261 ? -39.638 -3.479  -21.998 1    53.76  ? 431 ASN B O   1 
ATOM   4527 C  CB  . ASN B 2 261 ? -38.864 -2.179  -24.197 1    75.83  ? 431 ASN B CB  1 
ATOM   4528 C  CG  . ASN B 2 261 ? -38.274 -1.38   -25.338 1    82.38  ? 431 ASN B CG  1 
ATOM   4529 O  OD1 . ASN B 2 261 ? -37.26  -1.788  -25.92  1    87.39  ? 431 ASN B OD1 1 
ATOM   4530 N  ND2 . ASN B 2 261 ? -38.901 -0.263  -25.685 1    72.36  ? 431 ASN B ND2 1 
ATOM   4531 N  N   . VAL B 2 262 ? -39.93  -1.656  -20.669 1    62.32  ? 432 VAL B N   1 
ATOM   4532 C  CA  . VAL B 2 262 ? -40.189 -2.384  -19.435 1    64.81  ? 432 VAL B CA  1 
ATOM   4533 C  C   . VAL B 2 262 ? -41.664 -2.184  -19.03  1    75.56  ? 432 VAL B C   1 
ATOM   4534 O  O   . VAL B 2 262 ? -42.527 -2.228  -19.946 1    62.08  ? 432 VAL B O   1 
ATOM   4535 C  CB  . VAL B 2 262 ? -39.191 -1.969  -18.33  1    59.08  ? 432 VAL B CB  1 
ATOM   4536 C  CG1 . VAL B 2 262 ? -39.845 -1.547  -17.018 1    62.31  ? 432 VAL B CG1 1 
ATOM   4537 C  CG2 . VAL B 2 262 ? -38.093 -3.007  -18.123 1    46.83  ? 432 VAL B CG2 1 
ATOM   4538 N  N   . SER C 1 4   ? -14.828 4.549   28.815  1    39.52  ? 0   SER C N   1 
ATOM   4539 C  CA  . SER C 1 4   ? -16.304 4.363   28.692  1    45.44  ? 0   SER C CA  1 
ATOM   4540 C  C   . SER C 1 4   ? -16.972 5.69    28.329  1    40.42  ? 0   SER C C   1 
ATOM   4541 O  O   . SER C 1 4   ? -17.772 5.787   27.393  1    36.76  ? 0   SER C O   1 
ATOM   4542 C  CB  . SER C 1 4   ? -16.907 3.769   29.966  1    44.22  ? 0   SER C CB  1 
ATOM   4543 O  OG  . SER C 1 4   ? -16.944 2.35    29.896  1    49.7   ? 0   SER C OG  1 
ATOM   4544 N  N   . MET C 1 5   ? -16.617 6.697   29.126  1    34.08  ? 1   MET C N   1 
ATOM   4545 C  CA  . MET C 1 5   ? -17.076 8.054   28.948  1    31.66  ? 1   MET C CA  1 
ATOM   4546 C  C   . MET C 1 5   ? -15.919 8.921   28.45   1    30.11  ? 1   MET C C   1 
ATOM   4547 O  O   . MET C 1 5   ? -15.993 10.147  28.507  1    31.41  ? 1   MET C O   1 
ATOM   4548 C  CB  . MET C 1 5   ? -17.62  8.601   30.276  1    32.44  ? 1   MET C CB  1 
ATOM   4549 C  CG  . MET C 1 5   ? -18.655 7.74    30.934  1    28.08  ? 1   MET C CG  1 
ATOM   4550 S  SD  . MET C 1 5   ? -20.221 7.807   30.044  1    34.6   ? 1   MET C SD  1 
ATOM   4551 C  CE  . MET C 1 5   ? -20.632 9.544   30.282  1    36.21  ? 1   MET C CE  1 
ATOM   4552 N  N   . GLU C 1 6   ? -14.868 8.293   27.919  1    30.97  ? 2   GLU C N   1 
ATOM   4553 C  CA  . GLU C 1 6   ? -13.715 9.034   27.424  1    33.48  ? 2   GLU C CA  1 
ATOM   4554 C  C   . GLU C 1 6   ? -14.111 9.969   26.273  1    30.16  ? 2   GLU C C   1 
ATOM   4555 O  O   . GLU C 1 6   ? -13.453 10.985  26.066  1    27.95  ? 2   GLU C O   1 
ATOM   4556 C  CB  . GLU C 1 6   ? -12.565 8.082   27.079  1    39.97  ? 2   GLU C CB  1 
ATOM   4557 C  CG  . GLU C 1 6   ? -11.295 8.796   26.621  1    56.29  ? 2   GLU C CG  1 
ATOM   4558 C  CD  . GLU C 1 6   ? -10.578 9.681   27.639  1    74.25  ? 2   GLU C CD  1 
ATOM   4559 O  OE1 . GLU C 1 6   ? -10.926 9.573   28.842  1    83.03  ? 2   GLU C OE1 1 
ATOM   4560 O  OE2 . GLU C 1 6   ? -9.673  10.472  27.256  1    69.31  ? 2   GLU C OE2 1 
ATOM   4561 N  N   . ASN C 1 7   ? -15.195 9.636   25.544  1    31.33  ? 3   ASN C N   1 
ATOM   4562 C  CA  . ASN C 1 7   ? -15.643 10.413  24.394  1    32.02  ? 3   ASN C CA  1 
ATOM   4563 C  C   . ASN C 1 7   ? -16.591 11.546  24.773  1    29.53  ? 3   ASN C C   1 
ATOM   4564 O  O   . ASN C 1 7   ? -16.892 12.378  23.921  1    30.75  ? 3   ASN C O   1 
ATOM   4565 C  CB  . ASN C 1 7   ? -16.348 9.573   23.334  1    35.04  ? 3   ASN C CB  1 
ATOM   4566 C  CG  . ASN C 1 7   ? -15.394 8.632   22.645  1    38.25  ? 3   ASN C CG  1 
ATOM   4567 O  OD1 . ASN C 1 7   ? -14.229 8.984   22.39   1    38.51  ? 3   ASN C OD1 1 
ATOM   4568 N  ND2 . ASN C 1 7   ? -15.856 7.416   22.393  1    36.86  ? 3   ASN C ND2 1 
ATOM   4569 N  N   . PHE C 1 8   ? -17.073 11.579  26.023  1    27.61  ? 4   PHE C N   1 
ATOM   4570 C  CA  . PHE C 1 8   ? -17.925 12.678  26.467  1    26.6   ? 4   PHE C CA  1 
ATOM   4571 C  C   . PHE C 1 8   ? -17.091 13.739  27.177  1    27.69  ? 4   PHE C C   1 
ATOM   4572 O  O   . PHE C 1 8   ? -16.274 13.41   28.029  1    31.31  ? 4   PHE C O   1 
ATOM   4573 C  CB  . PHE C 1 8   ? -19.083 12.099  27.271  1    24.02  ? 4   PHE C CB  1 
ATOM   4574 C  CG  . PHE C 1 8   ? -20.012 11.286  26.39   1    22.84  ? 4   PHE C CG  1 
ATOM   4575 C  CD1 . PHE C 1 8   ? -20.807 11.908  25.438  1    21.35  ? 4   PHE C CD1 1 
ATOM   4576 C  CD2 . PHE C 1 8   ? -20.063 9.9     26.497  1    24.64  ? 4   PHE C CD2 1 
ATOM   4577 C  CE1 . PHE C 1 8   ? -21.641 11.147  24.626  1    23.25  ? 4   PHE C CE1 1 
ATOM   4578 C  CE2 . PHE C 1 8   ? -20.893 9.141   25.677  1    24.75  ? 4   PHE C CE2 1 
ATOM   4579 C  CZ  . PHE C 1 8   ? -21.684 9.762   24.741  1    23.78  ? 4   PHE C CZ  1 
ATOM   4580 N  N   . GLN C 1 9   ? -17.247 14.996  26.733  1    30.62  ? 5   GLN C N   1 
ATOM   4581 C  CA  . GLN C 1 9   ? -16.763 16.19   27.417  1    30.51  ? 5   GLN C CA  1 
ATOM   4582 C  C   . GLN C 1 9   ? -17.944 16.879  28.103  1    29.56  ? 5   GLN C C   1 
ATOM   4583 O  O   . GLN C 1 9   ? -18.922 17.239  27.44   1    26.78  ? 5   GLN C O   1 
ATOM   4584 C  CB  . GLN C 1 9   ? -16.137 17.141  26.397  1    32.37  ? 5   GLN C CB  1 
ATOM   4585 C  CG  . GLN C 1 9   ? -15.563 18.425  26.981  1    40.86  ? 5   GLN C CG  1 
ATOM   4586 C  CD  . GLN C 1 9   ? -14.273 18.184  27.734  1    51.78  ? 5   GLN C CD  1 
ATOM   4587 O  OE1 . GLN C 1 9   ? -13.284 17.689  27.181  1    58.95  ? 5   GLN C OE1 1 
ATOM   4588 N  NE2 . GLN C 1 9   ? -14.282 18.477  29.028  1    53.89  ? 5   GLN C NE2 1 
ATOM   4589 N  N   . LYS C 1 10  ? -17.867 17.036  29.437  1    32.34  ? 6   LYS C N   1 
ATOM   4590 C  CA  . LYS C 1 10  ? -18.878 17.779  30.184  1    35.92  ? 6   LYS C CA  1 
ATOM   4591 C  C   . LYS C 1 10  ? -18.878 19.246  29.764  1    34.29  ? 6   LYS C C   1 
ATOM   4592 O  O   . LYS C 1 10  ? -17.825 19.83   29.527  1    36.74  ? 6   LYS C O   1 
ATOM   4593 C  CB  . LYS C 1 10  ? -18.567 17.791  31.681  1    40.58  ? 6   LYS C CB  1 
ATOM   4594 C  CG  . LYS C 1 10  ? -19.225 16.682  32.493  1    51.21  ? 6   LYS C CG  1 
ATOM   4595 C  CD  . LYS C 1 10  ? -18.666 16.557  33.916  1    58.69  ? 6   LYS C CD  1 
ATOM   4596 C  CE  . LYS C 1 10  ? -18.596 17.849  34.691  1    59.03  ? 6   LYS C CE  1 
ATOM   4597 N  NZ  . LYS C 1 10  ? -18.016 17.639  36.017  1    54.74  ? 6   LYS C NZ  1 
ATOM   4598 N  N   . VAL C 1 11  ? -20.059 19.849  29.701  1    31.01  ? 7   VAL C N   1 
ATOM   4599 C  CA  . VAL C 1 11  ? -20.142 21.267  29.397  1    33.12  ? 7   VAL C CA  1 
ATOM   4600 C  C   . VAL C 1 11  ? -20.639 22.008  30.644  1    33.51  ? 7   VAL C C   1 
ATOM   4601 O  O   . VAL C 1 11  ? -19.969 22.89   31.135  1    39.59  ? 7   VAL C O   1 
ATOM   4602 C  CB  . VAL C 1 11  ? -21.01  21.515  28.149  1    33.93  ? 7   VAL C CB  1 
ATOM   4603 C  CG1 . VAL C 1 11  ? -21.245 22.99   27.9    1    31.79  ? 7   VAL C CG1 1 
ATOM   4604 C  CG2 . VAL C 1 11  ? -20.418 20.847  26.912  1    32.77  ? 7   VAL C CG2 1 
ATOM   4605 N  N   . GLU C 1 12  ? -21.792 21.624  31.197  1    38.25  ? 8   GLU C N   1 
ATOM   4606 C  CA  . GLU C 1 12  ? -22.336 22.263  32.384  1    38.86  ? 8   GLU C CA  1 
ATOM   4607 C  C   . GLU C 1 12  ? -23.375 21.347  33.034  1    42.25  ? 8   GLU C C   1 
ATOM   4608 O  O   . GLU C 1 12  ? -23.793 20.355  32.431  1    43.05  ? 8   GLU C O   1 
ATOM   4609 C  CB  . GLU C 1 12  ? -22.934 23.626  32.03   1    42.6   ? 8   GLU C CB  1 
ATOM   4610 C  CG  . GLU C 1 12  ? -24.239 23.509  31.252  1    49.97  ? 8   GLU C CG  1 
ATOM   4611 C  CD  . GLU C 1 12  ? -24.672 24.721  30.455  1    55.05  ? 8   GLU C CD  1 
ATOM   4612 O  OE1 . GLU C 1 12  ? -23.861 25.218  29.628  1    51.27  ? 8   GLU C OE1 1 
ATOM   4613 O  OE2 . GLU C 1 12  ? -25.853 25.115  30.655  1    64.81  ? 8   GLU C OE2 1 
ATOM   4614 N  N   . LYS C 1 13  ? -23.774 21.682  34.272  1    45.96  ? 9   LYS C N   1 
ATOM   4615 C  CA  . LYS C 1 13  ? -24.847 20.976  34.96   1    53.72  ? 9   LYS C CA  1 
ATOM   4616 C  C   . LYS C 1 13  ? -26.194 21.515  34.488  1    51.87  ? 9   LYS C C   1 
ATOM   4617 O  O   . LYS C 1 13  ? -26.311 22.709  34.205  1    58.89  ? 9   LYS C O   1 
ATOM   4618 C  CB  . LYS C 1 13  ? -24.673 21.161  36.467  1    63.42  ? 9   LYS C CB  1 
ATOM   4619 C  CG  . LYS C 1 13  ? -25.74  20.512  37.343  1    77.4   ? 9   LYS C CG  1 
ATOM   4620 C  CD  . LYS C 1 13  ? -25.292 20.386  38.796  1    85.18  ? 9   LYS C CD  1 
ATOM   4621 C  CE  . LYS C 1 13  ? -26.445 20.345  39.748  1    92.56  ? 9   LYS C CE  1 
ATOM   4622 N  NZ  . LYS C 1 13  ? -26.021 19.973  41.099  1    94.59  ? 9   LYS C NZ  1 
ATOM   4623 N  N   . ILE C 1 14  ? -27.202 20.639  34.373  1    40.51  ? 10  ILE C N   1 
ATOM   4624 C  CA  . ILE C 1 14  ? -28.498 21.122  33.935  1    43.29  ? 10  ILE C CA  1 
ATOM   4625 C  C   . ILE C 1 14  ? -29.614 20.655  34.864  1    52.02  ? 10  ILE C C   1 
ATOM   4626 O  O   . ILE C 1 14  ? -30.774 20.616  34.468  1    57.33  ? 10  ILE C O   1 
ATOM   4627 C  CB  . ILE C 1 14  ? -28.782 20.856  32.445  1    44.9   ? 10  ILE C CB  1 
ATOM   4628 C  CG1 . ILE C 1 14  ? -28.763 19.386  32.084  1    44.85  ? 10  ILE C CG1 1 
ATOM   4629 C  CG2 . ILE C 1 14  ? -27.857 21.685  31.553  1    50.3   ? 10  ILE C CG2 1 
ATOM   4630 C  CD1 . ILE C 1 14  ? -28.925 19.102  30.594  1    35.09  ? 10  ILE C CD1 1 
ATOM   4631 N  N   . GLY C 1 15  ? -29.25  20.318  36.089  1    56.78  ? 11  GLY C N   1 
ATOM   4632 C  CA  . GLY C 1 15  ? -30.327 19.985  37.022  1    65.85  ? 11  GLY C CA  1 
ATOM   4633 C  C   . GLY C 1 15  ? -30.083 18.689  37.73   1    74.85  ? 11  GLY C C   1 
ATOM   4634 O  O   . GLY C 1 15  ? -29.093 18.009  37.413  1    76.78  ? 11  GLY C O   1 
ATOM   4635 N  N   . GLU C 1 16  ? -30.961 18.38   38.675  1    81.31  ? 12  GLU C N   1 
ATOM   4636 C  CA  . GLU C 1 16  ? -30.786 17.15   39.471  1    83.34  ? 12  GLU C CA  1 
ATOM   4637 C  C   . GLU C 1 16  ? -32.134 16.442  39.554  1    91.53  ? 12  GLU C C   1 
ATOM   4638 O  O   . GLU C 1 16  ? -33.161 17.081  39.266  1    91.38  ? 12  GLU C O   1 
ATOM   4639 C  CB  . GLU C 1 16  ? -30.281 17.481  40.874  1    70.92  ? 12  GLU C CB  1 
ATOM   4640 C  CG  . GLU C 1 16  ? -28.784 17.763  40.928  1    74.19  ? 12  GLU C CG  1 
ATOM   4641 C  CD  . GLU C 1 16  ? -28.148 17.323  42.23   1    87.25  ? 12  GLU C CD  1 
ATOM   4642 O  OE1 . GLU C 1 16  ? -28.298 16.136  42.585  1    91.43  ? 12  GLU C OE1 1 
ATOM   4643 O  OE2 . GLU C 1 16  ? -27.508 18.167  42.891  1    83.86  ? 12  GLU C OE2 1 
ATOM   4644 N  N   . GLY C 1 17  ? -32.11  15.165  39.92   1    115.98 ? 13  GLY C N   1 
ATOM   4645 C  CA  . GLY C 1 17  ? -33.355 14.403  40.09   1    110.91 ? 13  GLY C CA  1 
ATOM   4646 C  C   . GLY C 1 17  ? -33.143 13.384  41.179  1    112.03 ? 13  GLY C C   1 
ATOM   4647 O  O   . GLY C 1 17  ? -32.168 13.533  41.946  1    98.38  ? 13  GLY C O   1 
ATOM   4648 N  N   . THR C 1 18  ? -34.006 12.374  41.244  1    117.52 ? 14  THR C N   1 
ATOM   4649 C  CA  . THR C 1 18  ? -33.898 11.375  42.319  1    125.28 ? 14  THR C CA  1 
ATOM   4650 C  C   . THR C 1 18  ? -32.651 10.563  42.069  1    122.52 ? 14  THR C C   1 
ATOM   4651 O  O   . THR C 1 18  ? -32.161 9.93    43.025  1    110.93 ? 14  THR C O   1 
ATOM   4652 C  CB  . THR C 1 18  ? -35.162 10.523  42.313  1    114.54 ? 14  THR C CB  1 
ATOM   4653 O  OG1 . THR C 1 18  ? -35.163 9.891   41.037  1    99.1   ? 14  THR C OG1 1 
ATOM   4654 C  CG2 . THR C 1 18  ? -36.418 11.356  42.486  1    85.06  ? 14  THR C CG2 1 
ATOM   4655 N  N   . TYR C 1 19  ? -32.133 10.601  40.839  1    108.77 ? 15  TYR C N   1 
ATOM   4656 C  CA  . TYR C 1 19  ? -30.951 9.788   40.464  1    94.27  ? 15  TYR C CA  1 
ATOM   4657 C  C   . TYR C 1 19  ? -29.696 10.447  40.948  1    99.62  ? 15  TYR C C   1 
ATOM   4658 O  O   . TYR C 1 19  ? -28.973 9.882   41.793  1    99.71  ? 15  TYR C O   1 
ATOM   4659 C  CB  . TYR C 1 19  ? -30.973 9.769   38.941  1    75.54  ? 15  TYR C CB  1 
ATOM   4660 C  CG  . TYR C 1 19  ? -32.184 9.02    38.407  1    66.29  ? 15  TYR C CG  1 
ATOM   4661 C  CD1 . TYR C 1 19  ? -32.311 7.649   38.588  1    50.58  ? 15  TYR C CD1 1 
ATOM   4662 C  CD2 . TYR C 1 19  ? -33.213 9.689   37.76   1    65.58  ? 15  TYR C CD2 1 
ATOM   4663 C  CE1 . TYR C 1 19  ? -33.408 6.958   38.108  1    45.73  ? 15  TYR C CE1 1 
ATOM   4664 C  CE2 . TYR C 1 19  ? -34.322 9.01    37.287  1    56.85  ? 15  TYR C CE2 1 
ATOM   4665 C  CZ  . TYR C 1 19  ? -34.417 7.642   37.459  1    47.4   ? 15  TYR C CZ  1 
ATOM   4666 O  OH  . TYR C 1 19  ? -35.502 6.97    36.984  1    43.01  ? 15  TYR C OH  1 
ATOM   4667 N  N   . GLY C 1 20  ? -29.418 11.623  40.401  1    93.19  ? 16  GLY C N   1 
ATOM   4668 C  CA  . GLY C 1 20  ? -28.21  12.358  40.786  1    78.98  ? 16  GLY C CA  1 
ATOM   4669 C  C   . GLY C 1 20  ? -28.219 13.686  40.079  1    76.92  ? 16  GLY C C   1 
ATOM   4670 O  O   . GLY C 1 20  ? -29.2   14.427  40.237  1    80.7   ? 16  GLY C O   1 
ATOM   4671 N  N   . VAL C 1 21  ? -27.191 13.947  39.282  1    70.54  ? 17  VAL C N   1 
ATOM   4672 C  CA  . VAL C 1 21  ? -27.142 15.216  38.511  1    60.84  ? 17  VAL C CA  1 
ATOM   4673 C  C   . VAL C 1 21  ? -27.261 14.914  37.013  1    58.89  ? 17  VAL C C   1 
ATOM   4674 O  O   . VAL C 1 21  ? -26.782 13.849  36.58   1    43.52  ? 17  VAL C O   1 
ATOM   4675 C  CB  . VAL C 1 21  ? -25.837 15.949  38.852  1    58.1   ? 17  VAL C CB  1 
ATOM   4676 C  CG1 . VAL C 1 21  ? -25.66  17.202  38.005  1    63.23  ? 17  VAL C CG1 1 
ATOM   4677 C  CG2 . VAL C 1 21  ? -25.706 16.251  40.337  1    63.9   ? 17  VAL C CG2 1 
ATOM   4678 N  N   . VAL C 1 22  ? -27.942 15.789  36.278  1    50.11  ? 18  VAL C N   1 
ATOM   4679 C  CA  . VAL C 1 22  ? -28.029 15.645  34.801  1    42.52  ? 18  VAL C CA  1 
ATOM   4680 C  C   . VAL C 1 22  ? -27.084 16.701  34.222  1    40.37  ? 18  VAL C C   1 
ATOM   4681 O  O   . VAL C 1 22  ? -27.134 17.855  34.67   1    39.11  ? 18  VAL C O   1 
ATOM   4682 C  CB  . VAL C 1 22  ? -29.46  15.814  34.262  1    41.88  ? 18  VAL C CB  1 
ATOM   4683 C  CG1 . VAL C 1 22  ? -29.551 15.492  32.777  1    38.25  ? 18  VAL C CG1 1 
ATOM   4684 C  CG2 . VAL C 1 22  ? -30.462 14.991  35.058  1    41.9   ? 18  VAL C CG2 1 
ATOM   4685 N  N   . TYR C 1 23  ? -26.224 16.3    33.281  1    38.82  ? 19  TYR C N   1 
ATOM   4686 C  CA  . TYR C 1 23  ? -25.208 17.249  32.754  1    34.99  ? 19  TYR C CA  1 
ATOM   4687 C  C   . TYR C 1 23  ? -25.198 17.256  31.242  1    29.57  ? 19  TYR C C   1 
ATOM   4688 O  O   . TYR C 1 23  ? -25.169 16.167  30.628  1    27.24  ? 19  TYR C O   1 
ATOM   4689 C  CB  . TYR C 1 23  ? -23.762 16.881  33.097  1    35.18  ? 19  TYR C CB  1 
ATOM   4690 C  CG  . TYR C 1 23  ? -23.46  16.316  34.478  1    50.38  ? 19  TYR C CG  1 
ATOM   4691 C  CD1 . TYR C 1 23  ? -23.8   15.012  34.817  1    61.55  ? 19  TYR C CD1 1 
ATOM   4692 C  CD2 . TYR C 1 23  ? -22.785 17.077  35.423  1    53.72  ? 19  TYR C CD2 1 
ATOM   4693 C  CE1 . TYR C 1 23  ? -23.508 14.493  36.067  1    67.84  ? 19  TYR C CE1 1 
ATOM   4694 C  CE2 . TYR C 1 23  ? -22.482 16.569  36.674  1    56.84  ? 19  TYR C CE2 1 
ATOM   4695 C  CZ  . TYR C 1 23  ? -22.845 15.274  36.997  1    63.97  ? 19  TYR C CZ  1 
ATOM   4696 O  OH  . TYR C 1 23  ? -22.552 14.776  38.233  1    77.1   ? 19  TYR C OH  1 
ATOM   4697 N  N   . LYS C 1 24  ? -25.207 18.447  30.643  1    27.29  ? 20  LYS C N   1 
ATOM   4698 C  CA  . LYS C 1 24  ? -25.052 18.546  29.207  1    26.25  ? 20  LYS C CA  1 
ATOM   4699 C  C   . LYS C 1 24  ? -23.594 18.256  28.878  1    25.86  ? 20  LYS C C   1 
ATOM   4700 O  O   . LYS C 1 24  ? -22.688 18.648  29.611  1    23.65  ? 20  LYS C O   1 
ATOM   4701 C  CB  . LYS C 1 24  ? -25.473 19.935  28.752  1    26.16  ? 20  LYS C CB  1 
ATOM   4702 C  CG  . LYS C 1 24  ? -25.061 20.33   27.354  1    28.8   ? 20  LYS C CG  1 
ATOM   4703 C  CD  . LYS C 1 24  ? -25.346 21.809  27.112  1    28.54  ? 20  LYS C CD  1 
ATOM   4704 C  CE  . LYS C 1 24  ? -24.808 22.292  25.813  1    30.59  ? 20  LYS C CE  1 
ATOM   4705 N  NZ  . LYS C 1 24  ? -25.654 23.353  25.278  1    34.21  ? 20  LYS C NZ  1 
ATOM   4706 N  N   . ALA C 1 25  ? -23.397 17.524  27.776  1    24.24  ? 21  ALA C N   1 
ATOM   4707 C  CA  . ALA C 1 25  ? -22.078 17.082  27.368  1    22.65  ? 21  ALA C CA  1 
ATOM   4708 C  C   . ALA C 1 25  ? -22.041 16.993  25.854  1    21.21  ? 21  ALA C C   1 
ATOM   4709 O  O   . ALA C 1 25  ? -23.067 17.123  25.183  1    22.55  ? 21  ALA C O   1 
ATOM   4710 C  CB  . ALA C 1 25  ? -21.792 15.745  27.986  1    24.54  ? 21  ALA C CB  1 
ATOM   4711 N  N   . ARG C 1 26  ? -20.836 16.794  25.34   1    19.43  ? 22  ARG C N   1 
ATOM   4712 C  CA  . ARG C 1 26  ? -20.589 16.829  23.914  1    21.85  ? 22  ARG C CA  1 
ATOM   4713 C  C   . ARG C 1 26  ? -19.765 15.592  23.546  1    24.92  ? 22  ARG C C   1 
ATOM   4714 O  O   . ARG C 1 26  ? -18.76  15.273  24.209  1    23.86  ? 22  ARG C O   1 
ATOM   4715 C  CB  . ARG C 1 26  ? -19.785 18.094  23.617  1    23.59  ? 22  ARG C CB  1 
ATOM   4716 C  CG  . ARG C 1 26  ? -19.703 18.538  22.167  1    31.36  ? 22  ARG C CG  1 
ATOM   4717 C  CD  . ARG C 1 26  ? -18.791 19.76   22.013  1    34.96  ? 22  ARG C CD  1 
ATOM   4718 N  NE  . ARG C 1 26  ? -17.435 19.23   21.8    1    50.63  ? 22  ARG C NE  1 
ATOM   4719 C  CZ  . ARG C 1 26  ? -16.298 19.439  22.489  1    50.77  ? 22  ARG C CZ  1 
ATOM   4720 N  NH1 . ARG C 1 26  ? -16.293 20.249  23.531  1    44.23  ? 22  ARG C NH1 1 
ATOM   4721 N  NH2 . ARG C 1 26  ? -15.193 18.812  22.124  1    46.76  ? 22  ARG C NH2 1 
ATOM   4722 N  N   . ASN C 1 27  ? -20.213 14.889  22.49   1    22.55  ? 23  ASN C N   1 
ATOM   4723 C  CA  . ASN C 1 27  ? -19.439 13.794  21.94   1    21.04  ? 23  ASN C CA  1 
ATOM   4724 C  C   . ASN C 1 27  ? -18.227 14.362  21.206  1    21.06  ? 23  ASN C C   1 
ATOM   4725 O  O   . ASN C 1 27  ? -18.386 15.068  20.224  1    22.31  ? 23  ASN C O   1 
ATOM   4726 C  CB  . ASN C 1 27  ? -20.29  12.89   21.06   1    21.09  ? 23  ASN C CB  1 
ATOM   4727 C  CG  . ASN C 1 27  ? -19.567 11.621  20.634  1    21.76  ? 23  ASN C CG  1 
ATOM   4728 O  OD1 . ASN C 1 27  ? -18.493 11.672  20      1    19.2   ? 23  ASN C OD1 1 
ATOM   4729 N  ND2 . ASN C 1 27  ? -20.171 10.475  20.94   1    18.06  ? 23  ASN C ND2 1 
ATOM   4730 N  N   . LYS C 1 28  ? -17.018 14.03   21.664  1    19.4   ? 24  LYS C N   1 
ATOM   4731 C  CA  . LYS C 1 28  ? -15.838 14.657  21.125  1    22.19  ? 24  LYS C CA  1 
ATOM   4732 C  C   . LYS C 1 28  ? -15.569 14.164  19.705  1    25.11  ? 24  LYS C C   1 
ATOM   4733 O  O   . LYS C 1 28  ? -14.832 14.794  18.946  1    29.59  ? 24  LYS C O   1 
ATOM   4734 C  CB  . LYS C 1 28  ? -14.623 14.249  21.958  1    28.32  ? 24  LYS C CB  1 
ATOM   4735 C  CG  . LYS C 1 28  ? -14.611 14.66   23.416  1    31.91  ? 24  LYS C CG  1 
ATOM   4736 C  CD  . LYS C 1 28  ? -13.3   14.241  24.078  1    34.15  ? 24  LYS C CD  1 
ATOM   4737 C  CE  . LYS C 1 28  ? -13.45  14.168  25.571  1    38.72  ? 24  LYS C CE  1 
ATOM   4738 N  NZ  . LYS C 1 28  ? -12.197 13.748  26.196  1    37.28  ? 24  LYS C NZ  1 
ATOM   4739 N  N   . LEU C 1 29  ? -16.104 12.998  19.359  1    25.32  ? 25  LEU C N   1 
ATOM   4740 C  CA  . LEU C 1 29  ? -15.796 12.432  18.059  1    24.75  ? 25  LEU C CA  1 
ATOM   4741 C  C   . LEU C 1 29  ? -16.877 12.798  17.033  1    27.93  ? 25  LEU C C   1 
ATOM   4742 O  O   . LEU C 1 29  ? -16.538 12.98   15.864  1    31.32  ? 25  LEU C O   1 
ATOM   4743 C  CB  . LEU C 1 29  ? -15.604 10.927  18.233  1    22.6   ? 25  LEU C CB  1 
ATOM   4744 C  CG  . LEU C 1 29  ? -14.222 10.465  18.71   1    17.85  ? 25  LEU C CG  1 
ATOM   4745 C  CD1 . LEU C 1 29  ? -14.262 8.971   19.017  1    15.1   ? 25  LEU C CD1 1 
ATOM   4746 C  CD2 . LEU C 1 29  ? -13.124 10.809  17.701  1    15.14  ? 25  LEU C CD2 1 
ATOM   4747 N  N   . THR C 1 30  ? -18.151 12.929  17.467  1    24.08  ? 26  THR C N   1 
ATOM   4748 C  CA  . THR C 1 30  ? -19.265 13.197  16.571  1    22.35  ? 26  THR C CA  1 
ATOM   4749 C  C   . THR C 1 30  ? -19.732 14.656  16.614  1    21.79  ? 26  THR C C   1 
ATOM   4750 O  O   . THR C 1 30  ? -20.345 15.139  15.662  1    22.74  ? 26  THR C O   1 
ATOM   4751 C  CB  . THR C 1 30  ? -20.43  12.246  16.836  1    22.78  ? 26  THR C CB  1 
ATOM   4752 O  OG1 . THR C 1 30  ? -20.937 12.561  18.12   1    21.88  ? 26  THR C OG1 1 
ATOM   4753 C  CG2 . THR C 1 30  ? -20.044 10.778  16.761  1    21.98  ? 26  THR C CG2 1 
ATOM   4754 N  N   . GLY C 1 31  ? -19.478 15.378  17.705  1    20.85  ? 27  GLY C N   1 
ATOM   4755 C  CA  . GLY C 1 31  ? -20.039 16.717  17.854  1    22.17  ? 27  GLY C CA  1 
ATOM   4756 C  C   . GLY C 1 31  ? -21.453 16.72   18.456  1    26.94  ? 27  GLY C C   1 
ATOM   4757 O  O   . GLY C 1 31  ? -21.984 17.766  18.819  1    32.03  ? 27  GLY C O   1 
ATOM   4758 N  N   . GLU C 1 32  ? -22.073 15.541  18.589  1    27.09  ? 28  GLU C N   1 
ATOM   4759 C  CA  . GLU C 1 32  ? -23.403 15.457  19.164  1    27.32  ? 28  GLU C CA  1 
ATOM   4760 C  C   . GLU C 1 32  ? -23.375 15.935  20.612  1    30.18  ? 28  GLU C C   1 
ATOM   4761 O  O   . GLU C 1 32  ? -22.556 15.492  21.418  1    33.81  ? 28  GLU C O   1 
ATOM   4762 C  CB  . GLU C 1 32  ? -23.907 14.019  19.08   1    27.82  ? 28  GLU C CB  1 
ATOM   4763 C  CG  . GLU C 1 32  ? -25.261 13.766  19.738  1    25.57  ? 28  GLU C CG  1 
ATOM   4764 C  CD  . GLU C 1 32  ? -25.631 12.282  19.692  1    30.12  ? 28  GLU C CD  1 
ATOM   4765 O  OE1 . GLU C 1 32  ? -24.739 11.41   19.953  1    30.5   ? 28  GLU C OE1 1 
ATOM   4766 O  OE2 . GLU C 1 32  ? -26.821 11.983  19.393  1    29.87  ? 28  GLU C OE2 1 
ATOM   4767 N  N   . VAL C 1 33  ? -24.302 16.844  20.92   1    28.79  ? 29  VAL C N   1 
ATOM   4768 C  CA  . VAL C 1 33  ? -24.525 17.372  22.258  1    23.72  ? 29  VAL C CA  1 
ATOM   4769 C  C   . VAL C 1 33  ? -25.548 16.475  22.934  1    20.55  ? 29  VAL C C   1 
ATOM   4770 O  O   . VAL C 1 33  ? -26.541 16.096  22.336  1    20.24  ? 29  VAL C O   1 
ATOM   4771 C  CB  . VAL C 1 33  ? -25.01  18.837  22.149  1    24.21  ? 29  VAL C CB  1 
ATOM   4772 C  CG1 . VAL C 1 33  ? -25.416 19.402  23.507  1    22.46  ? 29  VAL C CG1 1 
ATOM   4773 C  CG2 . VAL C 1 33  ? -23.98  19.74   21.445  1    20.04  ? 29  VAL C CG2 1 
ATOM   4774 N  N   . VAL C 1 34  ? -25.315 16.11   24.186  1    20.28  ? 30  VAL C N   1 
ATOM   4775 C  CA  . VAL C 1 34  ? -26.197 15.12   24.809  1    22.92  ? 30  VAL C CA  1 
ATOM   4776 C  C   . VAL C 1 34  ? -26.547 15.608  26.213  1    25.14  ? 30  VAL C C   1 
ATOM   4777 O  O   . VAL C 1 34  ? -25.968 16.572  26.698  1    30.61  ? 30  VAL C O   1 
ATOM   4778 C  CB  . VAL C 1 34  ? -25.632 13.67   24.824  1    16.76  ? 30  VAL C CB  1 
ATOM   4779 C  CG1 . VAL C 1 34  ? -25.333 13.168  23.425  1    14.77  ? 30  VAL C CG1 1 
ATOM   4780 C  CG2 . VAL C 1 34  ? -24.38  13.538  25.67   1    14.97  ? 30  VAL C CG2 1 
ATOM   4781 N  N   . ALA C 1 35  ? -27.479 14.927  26.867  1    26.29  ? 31  ALA C N   1 
ATOM   4782 C  CA  . ALA C 1 35  ? -27.621 15.075  28.304  1    28.93  ? 31  ALA C CA  1 
ATOM   4783 C  C   . ALA C 1 35  ? -27.266 13.733  28.932  1    32.8   ? 31  ALA C C   1 
ATOM   4784 O  O   . ALA C 1 35  ? -27.673 12.7    28.407  1    33.85  ? 31  ALA C O   1 
ATOM   4785 C  CB  . ALA C 1 35  ? -29.041 15.445  28.623  1    24.45  ? 31  ALA C CB  1 
ATOM   4786 N  N   . LEU C 1 36  ? -26.474 13.758  30.009  1    31.7   ? 32  LEU C N   1 
ATOM   4787 C  CA  . LEU C 1 36  ? -26.077 12.545  30.702  1    30.88  ? 32  LEU C CA  1 
ATOM   4788 C  C   . LEU C 1 36  ? -26.748 12.52   32.071  1    32.66  ? 32  LEU C C   1 
ATOM   4789 O  O   . LEU C 1 36  ? -26.617 13.464  32.849  1    39.62  ? 32  LEU C O   1 
ATOM   4790 C  CB  . LEU C 1 36  ? -24.556 12.541  30.826  1    29.05  ? 32  LEU C CB  1 
ATOM   4791 C  CG  . LEU C 1 36  ? -23.755 12.541  29.524  1    31.26  ? 32  LEU C CG  1 
ATOM   4792 C  CD1 . LEU C 1 36  ? -22.274 12.661  29.862  1    29.69  ? 32  LEU C CD1 1 
ATOM   4793 C  CD2 . LEU C 1 36  ? -24.005 11.262  28.719  1    35.2   ? 32  LEU C CD2 1 
ATOM   4794 N  N   . LYS C 1 37  ? -27.492 11.45   32.345  1    31.7   ? 33  LYS C N   1 
ATOM   4795 C  CA  . LYS C 1 37  ? -28.069 11.205  33.658  1    28.76  ? 33  LYS C CA  1 
ATOM   4796 C  C   . LYS C 1 37  ? -27.153 10.209  34.347  1    28.65  ? 33  LYS C C   1 
ATOM   4797 O  O   . LYS C 1 37  ? -26.948 9.116   33.849  1    30.63  ? 33  LYS C O   1 
ATOM   4798 C  CB  . LYS C 1 37  ? -29.511 10.713  33.506  1    30.98  ? 33  LYS C CB  1 
ATOM   4799 C  CG  . LYS C 1 37  ? -30.451 10.993  34.666  1    34.38  ? 33  LYS C CG  1 
ATOM   4800 C  CD  . LYS C 1 37  ? -31.864 10.455  34.513  1    37.5   ? 33  LYS C CD  1 
ATOM   4801 C  CE  . LYS C 1 37  ? -32.808 11.383  33.816  1    43.69  ? 33  LYS C CE  1 
ATOM   4802 N  NZ  . LYS C 1 37  ? -34.212 10.993  34.041  1    44.73  ? 33  LYS C NZ  1 
ATOM   4803 N  N   . LYS C 1 38  ? -26.504 10.644  35.419  1    29.94  ? 34  LYS C N   1 
ATOM   4804 C  CA  . LYS C 1 38  ? -25.618 9.786   36.175  1    32.93  ? 34  LYS C CA  1 
ATOM   4805 C  C   . LYS C 1 38  ? -26.443 9.199   37.317  1    37.54  ? 34  LYS C C   1 
ATOM   4806 O  O   . LYS C 1 38  ? -27.107 9.951   38.043  1    42.81  ? 34  LYS C O   1 
ATOM   4807 C  CB  . LYS C 1 38  ? -24.455 10.646  36.672  1    35.95  ? 34  LYS C CB  1 
ATOM   4808 C  CG  . LYS C 1 38  ? -23.344 9.914   37.401  1    44.16  ? 34  LYS C CG  1 
ATOM   4809 C  CD  . LYS C 1 38  ? -22.156 10.787  37.802  1    54.09  ? 34  LYS C CD  1 
ATOM   4810 C  CE  . LYS C 1 38  ? -22.35  11.548  39.074  1    62.6   ? 34  LYS C CE  1 
ATOM   4811 N  NZ  . LYS C 1 38  ? -22.275 10.624  40.208  1    67.23  ? 34  LYS C NZ  1 
ATOM   4812 N  N   . ILE C 1 39  ? -26.44  7.855   37.429  1    40.86  ? 35  ILE C N   1 
ATOM   4813 C  CA  . ILE C 1 39  ? -27.196 7.12    38.445  1    36.13  ? 35  ILE C CA  1 
ATOM   4814 C  C   . ILE C 1 39  ? -26.248 6.278   39.275  1    38.1   ? 35  ILE C C   1 
ATOM   4815 O  O   . ILE C 1 39  ? -25.737 5.291   38.755  1    44.03  ? 35  ILE C O   1 
ATOM   4816 C  CB  . ILE C 1 39  ? -28.274 6.22    37.823  1    30.45  ? 35  ILE C CB  1 
ATOM   4817 C  CG1 . ILE C 1 39  ? -29.279 7.027   37.063  1    27.34  ? 35  ILE C CG1 1 
ATOM   4818 C  CG2 . ILE C 1 39  ? -28.959 5.394   38.905  1    30.96  ? 35  ILE C CG2 1 
ATOM   4819 C  CD1 . ILE C 1 39  ? -30.235 6.19    36.261  1    31.07  ? 35  ILE C CD1 1 
ATOM   4820 N  N   . ARG C 1 40  ? -26.078 6.633   40.561  1    48.28  ? 36  ARG C N   1 
ATOM   4821 C  CA  . ARG C 1 40  ? -25.195 5.894   41.458  1    49.5   ? 36  ARG C CA  1 
ATOM   4822 C  C   . ARG C 1 40  ? -25.815 4.533   41.784  1    48.55  ? 36  ARG C C   1 
ATOM   4823 O  O   . ARG C 1 40  ? -26.996 4.458   42.155  1    44.73  ? 36  ARG C O   1 
ATOM   4824 C  CB  . ARG C 1 40  ? -24.983 6.657   42.767  1    64.55  ? 36  ARG C CB  1 
ATOM   4825 C  CG  . ARG C 1 40  ? -24.097 5.956   43.793  1    82.79  ? 36  ARG C CG  1 
ATOM   4826 C  CD  . ARG C 1 40  ? -22.671 5.661   43.321  1    95.91  ? 36  ARG C CD  1 
ATOM   4827 N  NE  . ARG C 1 40  ? -21.945 6.851   42.856  1    103.16 ? 36  ARG C NE  1 
ATOM   4828 C  CZ  . ARG C 1 40  ? -20.689 6.888   42.419  1    96.02  ? 36  ARG C CZ  1 
ATOM   4829 N  NH1 . ARG C 1 40  ? -19.957 5.788   42.405  1    101.56 ? 36  ARG C NH1 1 
ATOM   4830 N  NH2 . ARG C 1 40  ? -20.171 8.03    42.002  1    83.27  ? 36  ARG C NH2 1 
ATOM   4831 N  N   . LEU C 1 41  ? -25.007 3.475   41.622  1    40.18  ? 37  LEU C N   1 
ATOM   4832 C  CA  . LEU C 1 41  ? -25.408 2.123   41.971  1    38.59  ? 37  LEU C CA  1 
ATOM   4833 C  C   . LEU C 1 41  ? -24.955 1.8     43.397  1    46.44  ? 37  LEU C C   1 
ATOM   4834 O  O   . LEU C 1 41  ? -23.776 1.957   43.767  1    41.74  ? 37  LEU C O   1 
ATOM   4835 C  CB  . LEU C 1 41  ? -24.81  1.145   40.971  1    37.56  ? 37  LEU C CB  1 
ATOM   4836 C  CG  . LEU C 1 41  ? -25.232 1.311   39.51   1    37.11  ? 37  LEU C CG  1 
ATOM   4837 C  CD1 . LEU C 1 41  ? -24.86  0.071   38.692  1    31.94  ? 37  LEU C CD1 1 
ATOM   4838 C  CD2 . LEU C 1 41  ? -26.718 1.508   39.453  1    36.02  ? 37  LEU C CD2 1 
ATOM   4839 N  N   . ASP C 1 42  ? -25.924 1.32    44.188  1    43.64  ? 38  ASP C N   1 
ATOM   4840 C  CA  . ASP C 1 42  ? -25.702 0.902   45.567  1    40.69  ? 38  ASP C CA  1 
ATOM   4841 C  C   . ASP C 1 42  ? -25.179 -0.54   45.635  1    28.78  ? 38  ASP C C   1 
ATOM   4842 O  O   . ASP C 1 42  ? -25.921 -1.449  46.004  1    26.08  ? 38  ASP C O   1 
ATOM   4843 C  CB  . ASP C 1 42  ? -26.997 1.093   46.344  1    43.65  ? 38  ASP C CB  1 
ATOM   4844 C  CG  . ASP C 1 42  ? -27.46  2.537   46.45   1    42.79  ? 38  ASP C CG  1 
ATOM   4845 O  OD1 . ASP C 1 42  ? -26.676 3.34    46.992  1    50.04  ? 38  ASP C OD1 1 
ATOM   4846 O  OD2 . ASP C 1 42  ? -28.586 2.845   45.998  1    39.1   ? 38  ASP C OD2 1 
ATOM   4847 N  N   . THR C 1 43  ? -23.889 -0.737  45.344  1    21.54  ? 39  THR C N   1 
ATOM   4848 C  CA  . THR C 1 43  ? -23.339 -2.062  45.059  1    19.85  ? 39  THR C CA  1 
ATOM   4849 C  C   . THR C 1 43  ? -23.114 -2.939  46.297  1    18.7   ? 39  THR C C   1 
ATOM   4850 O  O   . THR C 1 43  ? -22.728 -4.101  46.167  1    18.5   ? 39  THR C O   1 
ATOM   4851 C  CB  . THR C 1 43  ? -22.04  -1.929  44.267  1    17.89  ? 39  THR C CB  1 
ATOM   4852 O  OG1 . THR C 1 43  ? -21.049 -1.41   45.139  1    20.31  ? 39  THR C OG1 1 
ATOM   4853 C  CG2 . THR C 1 43  ? -22.179 -0.98   43.098  1    17.29  ? 39  THR C CG2 1 
ATOM   4854 N  N   . GLU C 1 44  ? -23.291 -2.382  47.499  1    18.63  ? 40  GLU C N   1 
ATOM   4855 C  CA  . GLU C 1 44  ? -23.191 -3.196  48.696  1    20.14  ? 40  GLU C CA  1 
ATOM   4856 C  C   . GLU C 1 44  ? -24.543 -3.303  49.407  1    21.68  ? 40  GLU C C   1 
ATOM   4857 O  O   . GLU C 1 44  ? -24.603 -3.953  50.455  1    25.29  ? 40  GLU C O   1 
ATOM   4858 C  CB  . GLU C 1 44  ? -22.134 -2.671  49.666  1    18.54  ? 40  GLU C CB  1 
ATOM   4859 C  CG  . GLU C 1 44  ? -20.701 -2.756  49.149  1    18.65  ? 40  GLU C CG  1 
ATOM   4860 C  CD  . GLU C 1 44  ? -20.381 -1.834  47.981  1    20.78  ? 40  GLU C CD  1 
ATOM   4861 O  OE1 . GLU C 1 44  ? -19.774 -2.332  46.998  1    22.27  ? 40  GLU C OE1 1 
ATOM   4862 O  OE2 . GLU C 1 44  ? -20.755 -0.634  48.012  1    20.87  ? 40  GLU C OE2 1 
ATOM   4863 N  N   . THR C 1 45  ? -25.591 -2.652  48.874  1    18.97  ? 41  THR C N   1 
ATOM   4864 C  CA  . THR C 1 45  ? -26.865 -2.546  49.574  1    20.93  ? 41  THR C CA  1 
ATOM   4865 C  C   . THR C 1 45  ? -28.021 -2.883  48.636  1    24.05  ? 41  THR C C   1 
ATOM   4866 O  O   . THR C 1 45  ? -28.48  -4.015  48.662  1    31.75  ? 41  THR C O   1 
ATOM   4867 C  CB  . THR C 1 45  ? -27.059 -1.213  50.31   1    20.71  ? 41  THR C CB  1 
ATOM   4868 O  OG1 . THR C 1 45  ? -26.907 -0.144  49.372  1    21.87  ? 41  THR C OG1 1 
ATOM   4869 C  CG2 . THR C 1 45  ? -26.092 -1.022  51.467  1    19.77  ? 41  THR C CG2 1 
ATOM   4870 N  N   . GLU C 1 46  ? -28.495 -1.94   47.814  1    23.8   ? 42  GLU C N   1 
ATOM   4871 C  CA  . GLU C 1 46  ? -29.797 -2.078  47.178  1    25.67  ? 42  GLU C CA  1 
ATOM   4872 C  C   . GLU C 1 46  ? -29.702 -2.282  45.665  1    22.71  ? 42  GLU C C   1 
ATOM   4873 O  O   . GLU C 1 46  ? -30.725 -2.591  45.065  1    22.24  ? 42  GLU C O   1 
ATOM   4874 C  CB  . GLU C 1 46  ? -30.792 -0.965  47.538  1    29.87  ? 42  GLU C CB  1 
ATOM   4875 C  CG  . GLU C 1 46  ? -31.319 -1.004  48.979  1    37.63  ? 42  GLU C CG  1 
ATOM   4876 C  CD  . GLU C 1 46  ? -31.66  -2.321  49.71   1    45.81  ? 42  GLU C CD  1 
ATOM   4877 O  OE1 . GLU C 1 46  ? -32.543 -3.125  49.265  1    43.02  ? 42  GLU C OE1 1 
ATOM   4878 O  OE2 . GLU C 1 46  ? -31.05  -2.538  50.802  1    51.02  ? 42  GLU C OE2 1 
ATOM   4879 N  N   . GLY C 1 47  ? -28.518 -2.094  45.056  1    20.15  ? 43  GLY C N   1 
ATOM   4880 C  CA  . GLY C 1 47  ? -28.299 -2.364  43.641  1    18.2   ? 43  GLY C CA  1 
ATOM   4881 C  C   . GLY C 1 47  ? -28.856 -1.241  42.767  1    21.7   ? 43  GLY C C   1 
ATOM   4882 O  O   . GLY C 1 47  ? -28.749 -0.071  43.119  1    27.13  ? 43  GLY C O   1 
ATOM   4883 N  N   . VAL C 1 48  ? -29.45  -1.594  41.624  1    20.79  ? 44  VAL C N   1 
ATOM   4884 C  CA  . VAL C 1 48  ? -29.882 -0.625  40.634  1    20.67  ? 44  VAL C CA  1 
ATOM   4885 C  C   . VAL C 1 48  ? -31.284 -0.177  41.01   1    25.21  ? 44  VAL C C   1 
ATOM   4886 O  O   . VAL C 1 48  ? -32.174 -1.012  41.07   1    24.83  ? 44  VAL C O   1 
ATOM   4887 C  CB  . VAL C 1 48  ? -29.952 -1.266  39.24   1    19.06  ? 44  VAL C CB  1 
ATOM   4888 C  CG1 . VAL C 1 48  ? -30.438 -0.285  38.184  1    15.55  ? 44  VAL C CG1 1 
ATOM   4889 C  CG2 . VAL C 1 48  ? -28.631 -1.914  38.852  1    19.82  ? 44  VAL C CG2 1 
ATOM   4890 N  N   . PRO C 1 49  ? -31.549 1.139   41.222  1    26.22  ? 45  PRO C N   1 
ATOM   4891 C  CA  . PRO C 1 49  ? -32.862 1.578   41.685  1    21.79  ? 45  PRO C CA  1 
ATOM   4892 C  C   . PRO C 1 49  ? -33.94  1.216   40.682  1    24.38  ? 45  PRO C C   1 
ATOM   4893 O  O   . PRO C 1 49  ? -33.729 1.213   39.452  1    27.78  ? 45  PRO C O   1 
ATOM   4894 C  CB  . PRO C 1 49  ? -32.76  3.074   41.873  1    21.27  ? 45  PRO C CB  1 
ATOM   4895 C  CG  . PRO C 1 49  ? -31.533 3.468   41.098  1    22.25  ? 45  PRO C CG  1 
ATOM   4896 C  CD  . PRO C 1 49  ? -30.615 2.259   41.029  1    24.07  ? 45  PRO C CD  1 
ATOM   4897 N  N   . SER C 1 50  ? -35.117 0.955   41.246  1    23.85  ? 46  SER C N   1 
ATOM   4898 C  CA  . SER C 1 50  ? -36.25  0.519   40.458  1    25.1   ? 46  SER C CA  1 
ATOM   4899 C  C   . SER C 1 50  ? -36.712 1.638   39.526  1    27.36  ? 46  SER C C   1 
ATOM   4900 O  O   . SER C 1 50  ? -37.217 1.353   38.444  1    30.93  ? 46  SER C O   1 
ATOM   4901 C  CB  . SER C 1 50  ? -37.329 -0.036  41.349  1    23.69  ? 46  SER C CB  1 
ATOM   4902 O  OG  . SER C 1 50  ? -37.825 0.961   42.221  1    26.58  ? 46  SER C OG  1 
ATOM   4903 N  N   . THR C 1 51  ? -36.51  2.908   39.9    1    27.88  ? 47  THR C N   1 
ATOM   4904 C  CA  . THR C 1 51  ? -36.856 3.981   38.963  1    32.57  ? 47  THR C CA  1 
ATOM   4905 C  C   . THR C 1 51  ? -35.985 3.88    37.717  1    29.74  ? 47  THR C C   1 
ATOM   4906 O  O   . THR C 1 51  ? -36.438 4.177   36.627  1    33.33  ? 47  THR C O   1 
ATOM   4907 C  CB  . THR C 1 51  ? -36.811 5.404   39.521  1    33.66  ? 47  THR C CB  1 
ATOM   4908 O  OG1 . THR C 1 51  ? -35.532 5.514   40.125  1    42.01  ? 47  THR C OG1 1 
ATOM   4909 C  CG2 . THR C 1 51  ? -37.853 5.656   40.592  1    42.68  ? 47  THR C CG2 1 
ATOM   4910 N  N   . ALA C 1 52  ? -34.731 3.456   37.861  1    26.92  ? 48  ALA C N   1 
ATOM   4911 C  CA  . ALA C 1 52  ? -33.889 3.432   36.677  1    24.22  ? 48  ALA C CA  1 
ATOM   4912 C  C   . ALA C 1 52  ? -34.233 2.211   35.822  1    26.05  ? 48  ALA C C   1 
ATOM   4913 O  O   . ALA C 1 52  ? -34.222 2.302   34.589  1    25.18  ? 48  ALA C O   1 
ATOM   4914 C  CB  . ALA C 1 52  ? -32.418 3.468   37.046  1    18.83  ? 48  ALA C CB  1 
ATOM   4915 N  N   . ILE C 1 53  ? -34.527 1.073   36.486  1    24.17  ? 49  ILE C N   1 
ATOM   4916 C  CA  . ILE C 1 53  ? -34.951 -0.122  35.782  1    22.71  ? 49  ILE C CA  1 
ATOM   4917 C  C   . ILE C 1 53  ? -36.19  0.16    34.931  1    25.82  ? 49  ILE C C   1 
ATOM   4918 O  O   . ILE C 1 53  ? -36.22  -0.201  33.762  1    25.56  ? 49  ILE C O   1 
ATOM   4919 C  CB  . ILE C 1 53  ? -35.173 -1.269  36.761  1    22.42  ? 49  ILE C CB  1 
ATOM   4920 C  CG1 . ILE C 1 53  ? -33.866 -1.726  37.329  1    19.86  ? 49  ILE C CG1 1 
ATOM   4921 C  CG2 . ILE C 1 53  ? -35.911 -2.421  36.072  1    23.98  ? 49  ILE C CG2 1 
ATOM   4922 C  CD1 . ILE C 1 53  ? -34.081 -2.643  38.507  1    22.68  ? 49  ILE C CD1 1 
ATOM   4923 N  N   . ARG C 1 54  ? -37.161 0.883   35.491  1    26.01  ? 50  ARG C N   1 
ATOM   4924 C  CA  . ARG C 1 54  ? -38.337 1.275   34.732  1    32.04  ? 50  ARG C CA  1 
ATOM   4925 C  C   . ARG C 1 54  ? -38.017 2.311   33.653  1    33.37  ? 50  ARG C C   1 
ATOM   4926 O  O   . ARG C 1 54  ? -38.479 2.182   32.524  1    31.26  ? 50  ARG C O   1 
ATOM   4927 C  CB  . ARG C 1 54  ? -39.415 1.796   35.688  1    33.02  ? 50  ARG C CB  1 
ATOM   4928 C  CG  . ARG C 1 54  ? -40.123 0.687   36.452  1    28.17  ? 50  ARG C CG  1 
ATOM   4929 C  CD  . ARG C 1 54  ? -41.088 1.31    37.434  1    27.52  ? 50  ARG C CD  1 
ATOM   4930 N  NE  . ARG C 1 54  ? -41.827 0.26    38.118  1    27.85  ? 50  ARG C NE  1 
ATOM   4931 C  CZ  . ARG C 1 54  ? -42.624 0.484   39.145  1    33.08  ? 50  ARG C CZ  1 
ATOM   4932 N  NH1 . ARG C 1 54  ? -42.854 1.724   39.563  1    27.82  ? 50  ARG C NH1 1 
ATOM   4933 N  NH2 . ARG C 1 54  ? -43.187 -0.55   39.752  1    31.9   ? 50  ARG C NH2 1 
ATOM   4934 N  N   . GLU C 1 55  ? -37.257 3.355   34.007  1    31.9   ? 51  GLU C N   1 
ATOM   4935 C  CA  . GLU C 1 55  ? -36.957 4.409   33.057  1    31.76  ? 51  GLU C CA  1 
ATOM   4936 C  C   . GLU C 1 55  ? -36.264 3.825   31.823  1    33.96  ? 51  GLU C C   1 
ATOM   4937 O  O   . GLU C 1 55  ? -36.684 4.054   30.697  1    36.55  ? 51  GLU C O   1 
ATOM   4938 C  CB  . GLU C 1 55  ? -36.14  5.53    33.691  1    31.16  ? 51  GLU C CB  1 
ATOM   4939 C  CG  . GLU C 1 55  ? -35.865 6.677   32.72   1    32.03  ? 51  GLU C CG  1 
ATOM   4940 C  CD  . GLU C 1 55  ? -35.28  7.963   33.284  1    35.34  ? 51  GLU C CD  1 
ATOM   4941 O  OE1 . GLU C 1 55  ? -34.978 8.055   34.499  1    36.59  ? 51  GLU C OE1 1 
ATOM   4942 O  OE2 . GLU C 1 55  ? -35.159 8.912   32.489  1    37.51  ? 51  GLU C OE2 1 
ATOM   4943 N  N   . ILE C 1 56  ? -35.201 3.061   32.035  1    32.73  ? 52  ILE C N   1 
ATOM   4944 C  CA  . ILE C 1 56  ? -34.421 2.551   30.928  1    29.94  ? 52  ILE C CA  1 
ATOM   4945 C  C   . ILE C 1 56  ? -35.304 1.59    30.128  1    33.26  ? 52  ILE C C   1 
ATOM   4946 O  O   . ILE C 1 56  ? -35.441 1.747   28.917  1    33.28  ? 52  ILE C O   1 
ATOM   4947 C  CB  . ILE C 1 56  ? -33.117 1.907   31.453  1    29.63  ? 52  ILE C CB  1 
ATOM   4948 C  CG1 . ILE C 1 56  ? -32.241 2.935   32.158  1    26.13  ? 52  ILE C CG1 1 
ATOM   4949 C  CG2 . ILE C 1 56  ? -32.361 1.2     30.332  1    27.98  ? 52  ILE C CG2 1 
ATOM   4950 C  CD1 . ILE C 1 56  ? -31.122 2.372   33.016  1    26.11  ? 52  ILE C CD1 1 
ATOM   4951 N  N   . SER C 1 57  ? -35.939 0.625   30.807  1    36.07  ? 53  SER C N   1 
ATOM   4952 C  CA  . SER C 1 57  ? -36.694 -0.435  30.139  1    35.97  ? 53  SER C CA  1 
ATOM   4953 C  C   . SER C 1 57  ? -37.842 0.138   29.311  1    36.82  ? 53  SER C C   1 
ATOM   4954 O  O   . SER C 1 57  ? -38.073 -0.297  28.184  1    41.58  ? 53  SER C O   1 
ATOM   4955 C  CB  . SER C 1 57  ? -37.196 -1.499  31.096  1    35.26  ? 53  SER C CB  1 
ATOM   4956 O  OG  . SER C 1 57  ? -38.073 -0.943  32.073  1    41.2   ? 53  SER C OG  1 
ATOM   4957 N  N   . LEU C 1 58  ? -38.53  1.138   29.858  1    32.49  ? 54  LEU C N   1 
ATOM   4958 C  CA  . LEU C 1 58  ? -39.701 1.678   29.191  1    32.31  ? 54  LEU C CA  1 
ATOM   4959 C  C   . LEU C 1 58  ? -39.306 2.593   28.034  1    32.47  ? 54  LEU C C   1 
ATOM   4960 O  O   . LEU C 1 58  ? -39.939 2.521   26.993  1    45.96  ? 54  LEU C O   1 
ATOM   4961 C  CB  . LEU C 1 58  ? -40.675 2.306   30.181  1    29.27  ? 54  LEU C CB  1 
ATOM   4962 C  CG  . LEU C 1 58  ? -41.152 1.338   31.278  1    27.99  ? 54  LEU C CG  1 
ATOM   4963 C  CD1 . LEU C 1 58  ? -41.965 1.982   32.384  1    24.53  ? 54  LEU C CD1 1 
ATOM   4964 C  CD2 . LEU C 1 58  ? -41.919 0.191   30.684  1    25.72  ? 54  LEU C CD2 1 
ATOM   4965 N  N   . LEU C 1 59  ? -38.243 3.391   28.174  1    34.06  ? 55  LEU C N   1 
ATOM   4966 C  CA  . LEU C 1 59  ? -37.762 4.261   27.097  1    34.24  ? 55  LEU C CA  1 
ATOM   4967 C  C   . LEU C 1 59  ? -37.124 3.451   25.971  1    37.31  ? 55  LEU C C   1 
ATOM   4968 O  O   . LEU C 1 59  ? -37.174 3.857   24.811  1    39.35  ? 55  LEU C O   1 
ATOM   4969 C  CB  . LEU C 1 59  ? -36.754 5.278   27.624  1    30.35  ? 55  LEU C CB  1 
ATOM   4970 C  CG  . LEU C 1 59  ? -37.338 6.479   28.356  1    33.62  ? 55  LEU C CG  1 
ATOM   4971 C  CD1 . LEU C 1 59  ? -36.217 7.264   29.016  1    37.52  ? 55  LEU C CD1 1 
ATOM   4972 C  CD2 . LEU C 1 59  ? -38.142 7.364   27.416  1    30.55  ? 55  LEU C CD2 1 
ATOM   4973 N  N   . LYS C 1 60  ? -36.438 2.357   26.328  1    42.27  ? 56  LYS C N   1 
ATOM   4974 C  CA  . LYS C 1 60  ? -35.873 1.457   25.338  1    44.72  ? 56  LYS C CA  1 
ATOM   4975 C  C   . LYS C 1 60  ? -36.894 1.232   24.222  1    45.41  ? 56  LYS C C   1 
ATOM   4976 O  O   . LYS C 1 60  ? -36.523 1.213   23.048  1    52.05  ? 56  LYS C O   1 
ATOM   4977 C  CB  . LYS C 1 60  ? -35.452 0.122   25.973  1    47.29  ? 56  LYS C CB  1 
ATOM   4978 C  CG  . LYS C 1 60  ? -34.001 0       26.432  1    47.14  ? 56  LYS C CG  1 
ATOM   4979 C  CD  . LYS C 1 60  ? -33.062 -0.576  25.386  1    47.48  ? 56  LYS C CD  1 
ATOM   4980 C  CE  . LYS C 1 60  ? -33.095 -2.067  25.265  1    50.75  ? 56  LYS C CE  1 
ATOM   4981 N  NZ  . LYS C 1 60  ? -32.032 -2.569  24.386  1    48.83  ? 56  LYS C NZ  1 
ATOM   4982 N  N   . GLU C 1 61  ? -38.175 1.071   24.585  1    40.85  ? 57  GLU C N   1 
ATOM   4983 C  CA  . GLU C 1 61  ? -39.146 0.632   23.603  1    43.44  ? 57  GLU C CA  1 
ATOM   4984 C  C   . GLU C 1 61  ? -40.139 1.733   23.221  1    46.17  ? 57  GLU C C   1 
ATOM   4985 O  O   . GLU C 1 61  ? -41.034 1.489   22.42   1    60.54  ? 57  GLU C O   1 
ATOM   4986 C  CB  . GLU C 1 61  ? -39.777 -0.697  24.024  1    48.57  ? 57  GLU C CB  1 
ATOM   4987 C  CG  . GLU C 1 61  ? -40.582 -0.639  25.317  1    53.39  ? 57  GLU C CG  1 
ATOM   4988 C  CD  . GLU C 1 61  ? -41.43  -1.894  25.536  1    62.1   ? 57  GLU C CD  1 
ATOM   4989 O  OE1 . GLU C 1 61  ? -42.676 -1.716  25.52   1    70.24  ? 57  GLU C OE1 1 
ATOM   4990 O  OE2 . GLU C 1 61  ? -40.908 -3.026  25.74   1    58.07  ? 57  GLU C OE2 1 
ATOM   4991 N  N   . LEU C 1 62  ? -39.979 2.951   23.737  1    41.78  ? 58  LEU C N   1 
ATOM   4992 C  CA  . LEU C 1 62  ? -40.809 4.064   23.298  1    41.29  ? 58  LEU C CA  1 
ATOM   4993 C  C   . LEU C 1 62  ? -40.06  4.931   22.281  1    42.88  ? 58  LEU C C   1 
ATOM   4994 O  O   . LEU C 1 62  ? -39.5   5.955   22.652  1    50.58  ? 58  LEU C O   1 
ATOM   4995 C  CB  . LEU C 1 62  ? -41.251 4.881   24.517  1    38.67  ? 58  LEU C CB  1 
ATOM   4996 C  CG  . LEU C 1 62  ? -42.175 4.184   25.524  1    37.44  ? 58  LEU C CG  1 
ATOM   4997 C  CD1 . LEU C 1 62  ? -42.315 5.008   26.771  1    36.53  ? 58  LEU C CD1 1 
ATOM   4998 C  CD2 . LEU C 1 62  ? -43.551 3.882   24.983  1    35.85  ? 58  LEU C CD2 1 
ATOM   4999 N  N   . ASN C 1 63  ? -40.094 4.564   20.988  1    47.86  ? 59  ASN C N   1 
ATOM   5000 C  CA  . ASN C 1 63  ? -39.442 5.358   19.95   1    45.99  ? 59  ASN C CA  1 
ATOM   5001 C  C   . ASN C 1 63  ? -40.474 6.148   19.172  1    39.12  ? 59  ASN C C   1 
ATOM   5002 O  O   . ASN C 1 63  ? -41.191 5.579   18.353  1    44.09  ? 59  ASN C O   1 
ATOM   5003 C  CB  . ASN C 1 63  ? -38.523 4.533   19.056  1    59.49  ? 59  ASN C CB  1 
ATOM   5004 C  CG  . ASN C 1 63  ? -37.245 4.148   19.782  1    86.72  ? 59  ASN C CG  1 
ATOM   5005 O  OD1 . ASN C 1 63  ? -36.922 2.962   19.912  1    108.07 ? 59  ASN C OD1 1 
ATOM   5006 N  ND2 . ASN C 1 63  ? -36.507 5.126   20.291  1    85.45  ? 59  ASN C ND2 1 
ATOM   5007 N  N   . HIS C 1 64  ? -40.543 7.449   19.478  1    36.32  ? 60  HIS C N   1 
ATOM   5008 C  CA  . HIS C 1 64  ? -41.521 8.378   18.923  1    38.39  ? 60  HIS C CA  1 
ATOM   5009 C  C   . HIS C 1 64  ? -40.961 9.796   18.968  1    38.76  ? 60  HIS C C   1 
ATOM   5010 O  O   . HIS C 1 64  ? -40.27  10.17   19.91   1    38.48  ? 60  HIS C O   1 
ATOM   5011 C  CB  . HIS C 1 64  ? -42.861 8.343   19.671  1    36.98  ? 60  HIS C CB  1 
ATOM   5012 C  CG  . HIS C 1 64  ? -43.935 9.173   19.044  1    42.93  ? 60  HIS C CG  1 
ATOM   5013 N  ND1 . HIS C 1 64  ? -44.015 10.538  19.228  1    49.87  ? 60  HIS C ND1 1 
ATOM   5014 C  CD2 . HIS C 1 64  ? -44.98  8.862   18.258  1    41.15  ? 60  HIS C CD2 1 
ATOM   5015 C  CE1 . HIS C 1 64  ? -45.068 11.023  18.56   1    41.48  ? 60  HIS C CE1 1 
ATOM   5016 N  NE2 . HIS C 1 64  ? -45.677 10.025  17.98   1    38.11  ? 60  HIS C NE2 1 
ATOM   5017 N  N   . PRO C 1 65  ? -41.263 10.627  17.952  1    38.09  ? 61  PRO C N   1 
ATOM   5018 C  CA  . PRO C 1 65  ? -40.682 11.966  17.859  1    36.75  ? 61  PRO C CA  1 
ATOM   5019 C  C   . PRO C 1 65  ? -41.063 12.914  18.977  1    34.49  ? 61  PRO C C   1 
ATOM   5020 O  O   . PRO C 1 65  ? -40.459 13.976  19.044  1    40.45  ? 61  PRO C O   1 
ATOM   5021 C  CB  . PRO C 1 65  ? -41.121 12.571  16.519  1    35.29  ? 61  PRO C CB  1 
ATOM   5022 C  CG  . PRO C 1 65  ? -42.136 11.579  15.973  1    38.72  ? 61  PRO C CG  1 
ATOM   5023 C  CD  . PRO C 1 65  ? -42.171 10.314  16.84   1    32.25  ? 61  PRO C CD  1 
ATOM   5024 N  N   . ASN C 1 66  ? -42.059 12.553  19.8    1    31.77  ? 62  ASN C N   1 
ATOM   5025 C  CA  . ASN C 1 66  ? -42.461 13.402  20.923  1    34.46  ? 62  ASN C CA  1 
ATOM   5026 C  C   . ASN C 1 66  ? -42.203 12.709  22.268  1    38.05  ? 62  ASN C C   1 
ATOM   5027 O  O   . ASN C 1 66  ? -42.83  13.052  23.279  1    38.45  ? 62  ASN C O   1 
ATOM   5028 C  CB  . ASN C 1 66  ? -43.906 13.874  20.801  1    27.47  ? 62  ASN C CB  1 
ATOM   5029 C  CG  . ASN C 1 66  ? -44.135 14.671  19.547  1    31.02  ? 62  ASN C CG  1 
ATOM   5030 O  OD1 . ASN C 1 66  ? -44.921 14.258  18.688  1    40.95  ? 62  ASN C OD1 1 
ATOM   5031 N  ND2 . ASN C 1 66  ? -43.477 15.814  19.405  1    29.72  ? 62  ASN C ND2 1 
ATOM   5032 N  N   . ILE C 1 67  ? -41.308 11.712  22.262  1    32.99  ? 63  ILE C N   1 
ATOM   5033 C  CA  . ILE C 1 67  ? -40.792 11.116  23.484  1    30.24  ? 63  ILE C CA  1 
ATOM   5034 C  C   . ILE C 1 67  ? -39.268 11.206  23.436  1    34.41  ? 63  ILE C C   1 
ATOM   5035 O  O   . ILE C 1 67  ? -38.662 10.906  22.405  1    35.5   ? 63  ILE C O   1 
ATOM   5036 C  CB  . ILE C 1 67  ? -41.287 9.669   23.634  1    25.55  ? 63  ILE C CB  1 
ATOM   5037 C  CG1 . ILE C 1 67  ? -42.799 9.59    23.635  1    23.5   ? 63  ILE C CG1 1 
ATOM   5038 C  CG2 . ILE C 1 67  ? -40.713 9.022   24.886  1    26.21  ? 63  ILE C CG2 1 
ATOM   5039 C  CD1 . ILE C 1 67  ? -43.314 8.164   23.597  1    20.27  ? 63  ILE C CD1 1 
ATOM   5040 N  N   . VAL C 1 68  ? -38.665 11.645  24.55   1    34.97  ? 64  VAL C N   1 
ATOM   5041 C  CA  . VAL C 1 68  ? -37.244 11.968  24.581  1    33.97  ? 64  VAL C CA  1 
ATOM   5042 C  C   . VAL C 1 68  ? -36.474 10.686  24.253  1    32.33  ? 64  VAL C C   1 
ATOM   5043 O  O   . VAL C 1 68  ? -36.89  9.606   24.657  1    30.44  ? 64  VAL C O   1 
ATOM   5044 C  CB  . VAL C 1 68  ? -36.801 12.575  25.934  1    30.97  ? 64  VAL C CB  1 
ATOM   5045 C  CG1 . VAL C 1 68  ? -36.856 11.551  27.061  1    25.68  ? 64  VAL C CG1 1 
ATOM   5046 C  CG2 . VAL C 1 68  ? -35.398 13.173  25.863  1    29     ? 64  VAL C CG2 1 
ATOM   5047 N  N   . LYS C 1 69  ? -35.354 10.829  23.529  1    31.94  ? 65  LYS C N   1 
ATOM   5048 C  CA  . LYS C 1 69  ? -34.657 9.698   22.945  1    34.79  ? 65  LYS C CA  1 
ATOM   5049 C  C   . LYS C 1 69  ? -33.59  9.258   23.941  1    35.13  ? 65  LYS C C   1 
ATOM   5050 O  O   . LYS C 1 69  ? -32.759 10.077  24.351  1    36.77  ? 65  LYS C O   1 
ATOM   5051 C  CB  . LYS C 1 69  ? -34.098 10.102  21.574  1    36.48  ? 65  LYS C CB  1 
ATOM   5052 C  CG  . LYS C 1 69  ? -33.389 9.054   20.75   1    46.52  ? 65  LYS C CG  1 
ATOM   5053 C  CD  . LYS C 1 69  ? -34.291 7.935   20.224  1    60.03  ? 65  LYS C CD  1 
ATOM   5054 C  CE  . LYS C 1 69  ? -33.599 6.863   19.388  1    61.11  ? 65  LYS C CE  1 
ATOM   5055 N  NZ  . LYS C 1 69  ? -33.03  7.308   18.108  1    60.31  ? 65  LYS C NZ  1 
ATOM   5056 N  N   . LEU C 1 70  ? -33.67  7.987   24.371  1    31.68  ? 66  LEU C N   1 
ATOM   5057 C  CA  . LEU C 1 70  ? -32.579 7.365   25.108  1    30.82  ? 66  LEU C CA  1 
ATOM   5058 C  C   . LEU C 1 70  ? -31.612 6.764   24.088  1    33.7   ? 66  LEU C C   1 
ATOM   5059 O  O   . LEU C 1 70  ? -31.987 5.87    23.338  1    34.88  ? 66  LEU C O   1 
ATOM   5060 C  CB  . LEU C 1 70  ? -33.116 6.296   26.053  1    27.1   ? 66  LEU C CB  1 
ATOM   5061 C  CG  . LEU C 1 70  ? -32.082 5.652   26.979  1    28.15  ? 66  LEU C CG  1 
ATOM   5062 C  CD1 . LEU C 1 70  ? -31.337 6.664   27.859  1    23.04  ? 66  LEU C CD1 1 
ATOM   5063 C  CD2 . LEU C 1 70  ? -32.754 4.599   27.833  1    26.84  ? 66  LEU C CD2 1 
ATOM   5064 N  N   . LEU C 1 71  ? -30.393 7.311   24.029  1    29.87  ? 67  LEU C N   1 
ATOM   5065 C  CA  . LEU C 1 71  ? -29.459 6.988   22.964  1    26.93  ? 67  LEU C CA  1 
ATOM   5066 C  C   . LEU C 1 71  ? -28.61  5.794   23.383  1    26.82  ? 67  LEU C C   1 
ATOM   5067 O  O   . LEU C 1 71  ? -28.284 4.941   22.566  1    30.03  ? 67  LEU C O   1 
ATOM   5068 C  CB  . LEU C 1 71  ? -28.596 8.214   22.647  1    26.72  ? 67  LEU C CB  1 
ATOM   5069 C  CG  . LEU C 1 71  ? -29.331 9.461   22.128  1    24.93  ? 67  LEU C CG  1 
ATOM   5070 C  CD1 . LEU C 1 71  ? -28.43  10.676  22.138  1    20.8   ? 67  LEU C CD1 1 
ATOM   5071 C  CD2 . LEU C 1 71  ? -29.835 9.23    20.706  1    27.93  ? 67  LEU C CD2 1 
ATOM   5072 N  N   . ASP C 1 72  ? -28.263 5.733   24.672  1    27.01  ? 68  ASP C N   1 
ATOM   5073 C  CA  . ASP C 1 72  ? -27.329 4.729   25.132  1    24.58  ? 68  ASP C CA  1 
ATOM   5074 C  C   . ASP C 1 72  ? -27.421 4.591   26.647  1    27.37  ? 68  ASP C C   1 
ATOM   5075 O  O   . ASP C 1 72  ? -27.961 5.454   27.355  1    29.5   ? 68  ASP C O   1 
ATOM   5076 C  CB  . ASP C 1 72  ? -25.927 5.073   24.663  1    25     ? 68  ASP C CB  1 
ATOM   5077 C  CG  . ASP C 1 72  ? -24.974 3.896   24.561  1    28.39  ? 68  ASP C CG  1 
ATOM   5078 O  OD1 . ASP C 1 72  ? -25.378 2.764   24.902  1    29.44  ? 68  ASP C OD1 1 
ATOM   5079 O  OD2 . ASP C 1 72  ? -23.832 4.117   24.126  1    34.02  ? 68  ASP C OD2 1 
ATOM   5080 N  N   . VAL C 1 73  ? -26.905 3.456   27.117  1    28.18  ? 69  VAL C N   1 
ATOM   5081 C  CA  . VAL C 1 73  ? -26.687 3.23    28.531  1    26.94  ? 69  VAL C CA  1 
ATOM   5082 C  C   . VAL C 1 73  ? -25.293 2.656   28.692  1    26.07  ? 69  VAL C C   1 
ATOM   5083 O  O   . VAL C 1 73  ? -24.99  1.616   28.126  1    28.14  ? 69  VAL C O   1 
ATOM   5084 C  CB  . VAL C 1 73  ? -27.746 2.32    29.163  1    23.85  ? 69  VAL C CB  1 
ATOM   5085 C  CG1 . VAL C 1 73  ? -27.437 2.118   30.631  1    22.41  ? 69  VAL C CG1 1 
ATOM   5086 C  CG2 . VAL C 1 73  ? -29.123 2.94    29.012  1    27.1   ? 69  VAL C CG2 1 
ATOM   5087 N  N   . ILE C 1 74  ? -24.468 3.376   29.45   1    29.73  ? 70  ILE C N   1 
ATOM   5088 C  CA  . ILE C 1 74  ? -23.07  3.049   29.63   1    33.08  ? 70  ILE C CA  1 
ATOM   5089 C  C   . ILE C 1 74  ? -22.879 2.604   31.066  1    32.19  ? 70  ILE C C   1 
ATOM   5090 O  O   . ILE C 1 74  ? -23.175 3.364   31.976  1    35.64  ? 70  ILE C O   1 
ATOM   5091 C  CB  . ILE C 1 74  ? -22.184 4.248   29.256  1    32.69  ? 70  ILE C CB  1 
ATOM   5092 C  CG1 . ILE C 1 74  ? -22.378 4.585   27.78   1    31.32  ? 70  ILE C CG1 1 
ATOM   5093 C  CG2 . ILE C 1 74  ? -20.721 3.963   29.621  1    27.92  ? 70  ILE C CG2 1 
ATOM   5094 C  CD1 . ILE C 1 74  ? -21.182 5.262   27.124  1    44.43  ? 70  ILE C CD1 1 
ATOM   5095 N  N   . HIS C 1 75  ? -22.437 1.355   31.224  1    38.45  ? 71  HIS C N   1 
ATOM   5096 C  CA  . HIS C 1 75  ? -22.335 0.681   32.515  1    43.03  ? 71  HIS C CA  1 
ATOM   5097 C  C   . HIS C 1 75  ? -20.904 0.798   33.036  1    41.83  ? 71  HIS C C   1 
ATOM   5098 O  O   . HIS C 1 75  ? -19.945 0.861   32.268  1    42.87  ? 71  HIS C O   1 
ATOM   5099 C  CB  . HIS C 1 75  ? -22.634 -0.828  32.39   1    46.98  ? 71  HIS C CB  1 
ATOM   5100 C  CG  . HIS C 1 75  ? -23.982 -1.205  31.844  1    44.55  ? 71  HIS C CG  1 
ATOM   5101 N  ND1 . HIS C 1 75  ? -24.965 -1.814  32.602  1    38.9   ? 71  HIS C ND1 1 
ATOM   5102 C  CD2 . HIS C 1 75  ? -24.486 -1.077  30.585  1    46.51  ? 71  HIS C CD2 1 
ATOM   5103 C  CE1 . HIS C 1 75  ? -26.038 -2.013  31.836  1    44     ? 71  HIS C CE1 1 
ATOM   5104 N  NE2 . HIS C 1 75  ? -25.779 -1.574  30.604  1    43.96  ? 71  HIS C NE2 1 
ATOM   5105 N  N   . THR C 1 76  ? -20.779 0.866   34.357  1    42.42  ? 72  THR C N   1 
ATOM   5106 C  CA  . THR C 1 76  ? -19.524 0.575   35.035  1    40.4   ? 72  THR C CA  1 
ATOM   5107 C  C   . THR C 1 76  ? -19.923 -0.432  36.094  1    39.34  ? 72  THR C C   1 
ATOM   5108 O  O   . THR C 1 76  ? -21.096 -0.824  36.114  1    35.04  ? 72  THR C O   1 
ATOM   5109 C  CB  . THR C 1 76  ? -18.803 1.807   35.613  1    40.9   ? 72  THR C CB  1 
ATOM   5110 O  OG1 . THR C 1 76  ? -19.711 2.68    36.285  1    45.89  ? 72  THR C OG1 1 
ATOM   5111 C  CG2 . THR C 1 76  ? -18.086 2.646   34.561  1    39.79  ? 72  THR C CG2 1 
ATOM   5112 N  N   . GLU C 1 77  ? -18.958 -0.827  36.935  1    44.33  ? 73  GLU C N   1 
ATOM   5113 C  CA  . GLU C 1 77  ? -19.26  -1.658  38.088  1    40.27  ? 73  GLU C CA  1 
ATOM   5114 C  C   . GLU C 1 77  ? -20.025 -0.822  39.111  1    40.1   ? 73  GLU C C   1 
ATOM   5115 O  O   . GLU C 1 77  ? -20.837 -1.375  39.846  1    46.33  ? 73  GLU C O   1 
ATOM   5116 C  CB  . GLU C 1 77  ? -17.979 -2.332  38.578  1    44.74  ? 73  GLU C CB  1 
ATOM   5117 C  CG  . GLU C 1 77  ? -18.124 -3.081  39.902  1    58.35  ? 73  GLU C CG  1 
ATOM   5118 C  CD  . GLU C 1 77  ? -16.768 -3.509  40.473  1    67.65  ? 73  GLU C CD  1 
ATOM   5119 O  OE1 . GLU C 1 77  ? -16.678 -4.077  41.588  1    68.81  ? 73  GLU C OE1 1 
ATOM   5120 O  OE2 . GLU C 1 77  ? -15.762 -3.233  39.782  1    67.47  ? 73  GLU C OE2 1 
ATOM   5121 N  N   . ASN C 1 78  ? -19.825 0.511   39.094  1    42.01  ? 74  ASN C N   1 
ATOM   5122 C  CA  . ASN C 1 78  ? -20.223 1.406   40.181  1    39.51  ? 74  ASN C CA  1 
ATOM   5123 C  C   . ASN C 1 78  ? -21.27  2.437   39.762  1    41.91  ? 74  ASN C C   1 
ATOM   5124 O  O   . ASN C 1 78  ? -22.026 2.924   40.6    1    43.1   ? 74  ASN C O   1 
ATOM   5125 C  CB  . ASN C 1 78  ? -18.998 2.028   40.83   1    38.97  ? 74  ASN C CB  1 
ATOM   5126 C  CG  . ASN C 1 78  ? -18.156 0.985   41.548  1    43.88  ? 74  ASN C CG  1 
ATOM   5127 O  OD1 . ASN C 1 78  ? -17.135 0.532   41.019  1    42.11  ? 74  ASN C OD1 1 
ATOM   5128 N  ND2 . ASN C 1 78  ? -18.568 0.544   42.732  1    39.73  ? 74  ASN C ND2 1 
ATOM   5129 N  N   . LYS C 1 79  ? -21.315 2.787   38.471  1    45.02  ? 75  LYS C N   1 
ATOM   5130 C  CA  . LYS C 1 79  ? -22.211 3.841   38.018  1    40.01  ? 75  LYS C CA  1 
ATOM   5131 C  C   . LYS C 1 79  ? -22.974 3.428   36.769  1    35.12  ? 75  LYS C C   1 
ATOM   5132 O  O   . LYS C 1 79  ? -22.551 2.568   36.012  1    43.03  ? 75  LYS C O   1 
ATOM   5133 C  CB  . LYS C 1 79  ? -21.401 5.086   37.657  1    46.23  ? 75  LYS C CB  1 
ATOM   5134 C  CG  . LYS C 1 79  ? -21.232 6.069   38.793  1    59.66  ? 75  LYS C CG  1 
ATOM   5135 C  CD  . LYS C 1 79  ? -20.099 7.064   38.559  1    66.02  ? 75  LYS C CD  1 
ATOM   5136 C  CE  . LYS C 1 79  ? -18.774 6.383   38.339  1    66.77  ? 75  LYS C CE  1 
ATOM   5137 N  NZ  . LYS C 1 79  ? -17.685 7.358   38.449  1    58.3   ? 75  LYS C NZ  1 
ATOM   5138 N  N   . LEU C 1 80  ? -24.102 4.089   36.545  1    29.21  ? 76  LEU C N   1 
ATOM   5139 C  CA  . LEU C 1 80  ? -24.814 3.967   35.287  1    27.43  ? 76  LEU C CA  1 
ATOM   5140 C  C   . LEU C 1 80  ? -24.946 5.359   34.664  1    29.78  ? 76  LEU C C   1 
ATOM   5141 O  O   . LEU C 1 80  ? -25.392 6.288   35.344  1    31.07  ? 76  LEU C O   1 
ATOM   5142 C  CB  . LEU C 1 80  ? -26.176 3.406   35.683  1    27.17  ? 76  LEU C CB  1 
ATOM   5143 C  CG  . LEU C 1 80  ? -26.755 2.317   34.789  1    29.94  ? 76  LEU C CG  1 
ATOM   5144 C  CD1 . LEU C 1 80  ? -25.802 1.115   34.733  1    36.56  ? 76  LEU C CD1 1 
ATOM   5145 C  CD2 . LEU C 1 80  ? -28.066 1.926   35.43   1    32.69  ? 76  LEU C CD2 1 
ATOM   5146 N  N   . TYR C 1 81  ? -24.527 5.526   33.397  1    26.06  ? 77  TYR C N   1 
ATOM   5147 C  CA  . TYR C 1 81  ? -24.803 6.772   32.694  1    26.69  ? 77  TYR C CA  1 
ATOM   5148 C  C   . TYR C 1 81  ? -25.869 6.551   31.621  1    30.33  ? 77  TYR C C   1 
ATOM   5149 O  O   . TYR C 1 81  ? -25.709 5.714   30.742  1    35.82  ? 77  TYR C O   1 
ATOM   5150 C  CB  . TYR C 1 81  ? -23.562 7.34    32.023  1    26.45  ? 77  TYR C CB  1 
ATOM   5151 C  CG  . TYR C 1 81  ? -22.456 7.755   32.972  1    29.41  ? 77  TYR C CG  1 
ATOM   5152 C  CD1 . TYR C 1 81  ? -21.537 6.835   33.443  1    29.31  ? 77  TYR C CD1 1 
ATOM   5153 C  CD2 . TYR C 1 81  ? -22.311 9.075   33.359  1    31.93  ? 77  TYR C CD2 1 
ATOM   5154 C  CE1 . TYR C 1 81  ? -20.505 7.214   34.286  1    35.71  ? 77  TYR C CE1 1 
ATOM   5155 C  CE2 . TYR C 1 81  ? -21.282 9.468   34.198  1    33.5   ? 77  TYR C CE2 1 
ATOM   5156 C  CZ  . TYR C 1 81  ? -20.378 8.536   34.675  1    38.1   ? 77  TYR C CZ  1 
ATOM   5157 O  OH  . TYR C 1 81  ? -19.346 8.93    35.5    1    42.54  ? 77  TYR C OH  1 
ATOM   5158 N  N   . LEU C 1 82  ? -26.95  7.335   31.682  1    27.25  ? 78  LEU C N   1 
ATOM   5159 C  CA  . LEU C 1 82  ? -27.937 7.341   30.626  1    25.34  ? 78  LEU C CA  1 
ATOM   5160 C  C   . LEU C 1 82  ? -27.601 8.468   29.651  1    25.99  ? 78  LEU C C   1 
ATOM   5161 O  O   . LEU C 1 82  ? -27.415 9.605   30.05   1    25.28  ? 78  LEU C O   1 
ATOM   5162 C  CB  . LEU C 1 82  ? -29.337 7.538   31.216  1    28.73  ? 78  LEU C CB  1 
ATOM   5163 C  CG  . LEU C 1 82  ? -29.842 6.625   32.355  1    25.5   ? 78  LEU C CG  1 
ATOM   5164 C  CD1 . LEU C 1 82  ? -31.318 6.409   32.167  1    22.65  ? 78  LEU C CD1 1 
ATOM   5165 C  CD2 . LEU C 1 82  ? -29.14  5.301   32.537  1    30.47  ? 78  LEU C CD2 1 
ATOM   5166 N  N   . VAL C 1 83  ? -27.529 8.151   28.364  1    24.72  ? 79  VAL C N   1 
ATOM   5167 C  CA  . VAL C 1 83  ? -27.257 9.173   27.381  1    23.87  ? 79  VAL C CA  1 
ATOM   5168 C  C   . VAL C 1 83  ? -28.565 9.533   26.689  1    26.61  ? 79  VAL C C   1 
ATOM   5169 O  O   . VAL C 1 83  ? -29.16  8.697   25.992  1    31.26  ? 79  VAL C O   1 
ATOM   5170 C  CB  . VAL C 1 83  ? -26.232 8.682   26.348  1    21.28  ? 79  VAL C CB  1 
ATOM   5171 C  CG1 . VAL C 1 83  ? -25.871 9.802   25.393  1    20.45  ? 79  VAL C CG1 1 
ATOM   5172 C  CG2 . VAL C 1 83  ? -24.981 8.187   27.022  1    21.3   ? 79  VAL C CG2 1 
ATOM   5173 N  N   . PHE C 1 84  ? -28.959 10.803  26.84   1    25.88  ? 80  PHE C N   1 
ATOM   5174 C  CA  . PHE C 1 84  ? -30.176 11.342  26.24   1    24.38  ? 80  PHE C CA  1 
ATOM   5175 C  C   . PHE C 1 84  ? -29.836 12.313  25.117  1    23.38  ? 80  PHE C C   1 
ATOM   5176 O  O   . PHE C 1 84  ? -28.745 12.887  25.091  1    23.97  ? 80  PHE C O   1 
ATOM   5177 C  CB  . PHE C 1 84  ? -31.021 12.102  27.261  1    22.59  ? 80  PHE C CB  1 
ATOM   5178 C  CG  . PHE C 1 84  ? -31.725 11.2    28.255  1    24.68  ? 80  PHE C CG  1 
ATOM   5179 C  CD1 . PHE C 1 84  ? -32.921 10.589  27.906  1    27.44  ? 80  PHE C CD1 1 
ATOM   5180 C  CD2 . PHE C 1 84  ? -31.173 10.93   29.503  1    27.91  ? 80  PHE C CD2 1 
ATOM   5181 C  CE1 . PHE C 1 84  ? -33.563 9.752   28.793  1    26.6   ? 80  PHE C CE1 1 
ATOM   5182 C  CE2 . PHE C 1 84  ? -31.823 10.087  30.39   1    28.17  ? 80  PHE C CE2 1 
ATOM   5183 C  CZ  . PHE C 1 84  ? -33.015 9.516   30.033  1    26.89  ? 80  PHE C CZ  1 
ATOM   5184 N  N   . GLU C 1 85  ? -30.779 12.485  24.185  1    23.91  ? 81  GLU C N   1 
ATOM   5185 C  CA  . GLU C 1 85  ? -30.633 13.563  23.223  1    27.31  ? 81  GLU C CA  1 
ATOM   5186 C  C   . GLU C 1 85  ? -30.744 14.851  24.038  1    29.85  ? 81  GLU C C   1 
ATOM   5187 O  O   . GLU C 1 85  ? -31.38  14.839  25.087  1    32.39  ? 81  GLU C O   1 
ATOM   5188 C  CB  . GLU C 1 85  ? -31.675 13.467  22.11   1    23.6   ? 81  GLU C CB  1 
ATOM   5189 C  CG  . GLU C 1 85  ? -33.057 13.844  22.617  1    28.08  ? 81  GLU C CG  1 
ATOM   5190 C  CD  . GLU C 1 85  ? -34.211 13.871  21.642  1    32.79  ? 81  GLU C CD  1 
ATOM   5191 O  OE1 . GLU C 1 85  ? -34.133 14.648  20.664  1    37.33  ? 81  GLU C OE1 1 
ATOM   5192 O  OE2 . GLU C 1 85  ? -35.202 13.151  21.885  1    33.49  ? 81  GLU C OE2 1 
ATOM   5193 N  N   . PHE C 1 86  ? -30.111 15.933  23.579  1    28.12  ? 82  PHE C N   1 
ATOM   5194 C  CA  . PHE C 1 86  ? -30.166 17.198  24.285  1    29.56  ? 82  PHE C CA  1 
ATOM   5195 C  C   . PHE C 1 86  ? -31.252 18.042  23.654  1    32.04  ? 82  PHE C C   1 
ATOM   5196 O  O   . PHE C 1 86  ? -31.294 18.148  22.435  1    34.28  ? 82  PHE C O   1 
ATOM   5197 C  CB  . PHE C 1 86  ? -28.843 17.947  24.181  1    28.7   ? 82  PHE C CB  1 
ATOM   5198 C  CG  . PHE C 1 86  ? -28.862 19.3    24.849  1    32.64  ? 82  PHE C CG  1 
ATOM   5199 C  CD1 . PHE C 1 86  ? -28.825 19.399  26.246  1    36.12  ? 82  PHE C CD1 1 
ATOM   5200 C  CD2 . PHE C 1 86  ? -28.919 20.469  24.086  1    33.57  ? 82  PHE C CD2 1 
ATOM   5201 C  CE1 . PHE C 1 86  ? -28.835 20.645  26.871  1    32.61  ? 82  PHE C CE1 1 
ATOM   5202 C  CE2 . PHE C 1 86  ? -28.923 21.714  24.709  1    32.47  ? 82  PHE C CE2 1 
ATOM   5203 C  CZ  . PHE C 1 86  ? -28.882 21.796  26.096  1    35.39  ? 82  PHE C CZ  1 
ATOM   5204 N  N   . LEU C 1 87  ? -32.145 18.568  24.499  1    34.33  ? 83  LEU C N   1 
ATOM   5205 C  CA  . LEU C 1 87  ? -33.108 19.585  24.115  1    35.72  ? 83  LEU C CA  1 
ATOM   5206 C  C   . LEU C 1 87  ? -32.844 20.858  24.915  1    36.42  ? 83  LEU C C   1 
ATOM   5207 O  O   . LEU C 1 87  ? -32.48  20.799  26.083  1    38.76  ? 83  LEU C O   1 
ATOM   5208 C  CB  . LEU C 1 87  ? -34.53  19.064  24.263  1    34.37  ? 83  LEU C CB  1 
ATOM   5209 C  CG  . LEU C 1 87  ? -34.97  18.093  23.167  1    37.87  ? 83  LEU C CG  1 
ATOM   5210 C  CD1 . LEU C 1 87  ? -34.969 16.686  23.689  1    42.79  ? 83  LEU C CD1 1 
ATOM   5211 C  CD2 . LEU C 1 87  ? -36.344 18.439  22.665  1    41.52  ? 83  LEU C CD2 1 
ATOM   5212 N  N   . HIS C 1 88  ? -33.024 21.997  24.248  1    46.68  ? 84  HIS C N   1 
ATOM   5213 C  CA  . HIS C 1 88  ? -32.612 23.331  24.673  1    51.51  ? 84  HIS C CA  1 
ATOM   5214 C  C   . HIS C 1 88  ? -33.108 23.744  26.068  1    42.02  ? 84  HIS C C   1 
ATOM   5215 O  O   . HIS C 1 88  ? -32.345 24.352  26.809  1    40.79  ? 84  HIS C O   1 
ATOM   5216 C  CB  . HIS C 1 88  ? -33.05  24.341  23.613  1    52.77  ? 84  HIS C CB  1 
ATOM   5217 C  CG  . HIS C 1 88  ? -32.823 25.738  24.034  1    69.22  ? 84  HIS C CG  1 
ATOM   5218 N  ND1 . HIS C 1 88  ? -33.863 26.59   24.335  1    76.24  ? 84  HIS C ND1 1 
ATOM   5219 C  CD2 . HIS C 1 88  ? -31.689 26.432  24.188  1    75.87  ? 84  HIS C CD2 1 
ATOM   5220 C  CE1 . HIS C 1 88  ? -33.359 27.773  24.668  1    85.98  ? 84  HIS C CE1 1 
ATOM   5221 N  NE2 . HIS C 1 88  ? -32.042 27.694  24.594  1    87.52  ? 84  HIS C NE2 1 
ATOM   5222 N  N   . GLN C 1 89  ? -34.392 23.51   26.394  1    36.91  ? 85  GLN C N   1 
ATOM   5223 C  CA  . GLN C 1 89  ? -34.903 23.681  27.752  1    35.89  ? 85  GLN C CA  1 
ATOM   5224 C  C   . GLN C 1 89  ? -36.288 23.055  27.913  1    35.7   ? 85  GLN C C   1 
ATOM   5225 O  O   . GLN C 1 89  ? -36.825 22.446  26.989  1    39.75  ? 85  GLN C O   1 
ATOM   5226 C  CB  . GLN C 1 89  ? -34.999 25.125  28.241  1    38.29  ? 85  GLN C CB  1 
ATOM   5227 C  CG  . GLN C 1 89  ? -35.955 25.984  27.414  1    44.49  ? 85  GLN C CG  1 
ATOM   5228 C  CD  . GLN C 1 89  ? -35.875 27.428  27.854  1    44.56  ? 85  GLN C CD  1 
ATOM   5229 O  OE1 . GLN C 1 89  ? -35.269 27.743  28.884  1    44.65  ? 85  GLN C OE1 1 
ATOM   5230 N  NE2 . GLN C 1 89  ? -36.482 28.311  27.079  1    43.57  ? 85  GLN C NE2 1 
ATOM   5231 N  N   . ASP C 1 90  ? -36.865 23.232  29.109  1    32.75  ? 86  ASP C N   1 
ATOM   5232 C  CA  . ASP C 1 90  ? -38.133 22.636  29.487  1    29.52  ? 86  ASP C CA  1 
ATOM   5233 C  C   . ASP C 1 90  ? -39.238 23.694  29.484  1    33.27  ? 86  ASP C C   1 
ATOM   5234 O  O   . ASP C 1 90  ? -38.981 24.886  29.637  1    38.44  ? 86  ASP C O   1 
ATOM   5235 C  CB  . ASP C 1 90  ? -38.038 22.004  30.869  1    30.42  ? 86  ASP C CB  1 
ATOM   5236 C  CG  . ASP C 1 90  ? -37.715 22.968  31.999  1    31.78  ? 86  ASP C CG  1 
ATOM   5237 O  OD1 . ASP C 1 90  ? -38.619 23.731  32.419  1    29.3   ? 86  ASP C OD1 1 
ATOM   5238 O  OD2 . ASP C 1 90  ? -36.545 22.97   32.42   1    36.55  ? 86  ASP C OD2 1 
ATOM   5239 N  N   . LEU C 1 91  ? -40.484 23.214  29.433  1    30.86  ? 87  LEU C N   1 
ATOM   5240 C  CA  . LEU C 1 91  ? -41.645 24.046  29.22   1    31.2   ? 87  LEU C CA  1 
ATOM   5241 C  C   . LEU C 1 91  ? -41.805 25.028  30.378  1    33.81  ? 87  LEU C C   1 
ATOM   5242 O  O   . LEU C 1 91  ? -42.252 26.147  30.169  1    35.06  ? 87  LEU C O   1 
ATOM   5243 C  CB  . LEU C 1 91  ? -42.86  23.129  29.053  1    29.83  ? 87  LEU C CB  1 
ATOM   5244 C  CG  . LEU C 1 91  ? -44.172 23.828  28.67   1    25.66  ? 87  LEU C CG  1 
ATOM   5245 C  CD1 . LEU C 1 91  ? -44.007 24.495  27.317  1    22.8   ? 87  LEU C CD1 1 
ATOM   5246 C  CD2 . LEU C 1 91  ? -45.319 22.812  28.651  1    22.88  ? 87  LEU C CD2 1 
ATOM   5247 N  N   . LYS C 1 92  ? -41.459 24.612  31.596  1    33.36  ? 88  LYS C N   1 
ATOM   5248 C  CA  . LYS C 1 92  ? -41.607 25.484  32.757  1    30.98  ? 88  LYS C CA  1 
ATOM   5249 C  C   . LYS C 1 92  ? -40.714 26.705  32.582  1    29.88  ? 88  LYS C C   1 
ATOM   5250 O  O   . LYS C 1 92  ? -41.117 27.827  32.865  1    32.16  ? 88  LYS C O   1 
ATOM   5251 C  CB  . LYS C 1 92  ? -41.273 24.76   34.069  1    28.06  ? 88  LYS C CB  1 
ATOM   5252 C  CG  . LYS C 1 92  ? -41.075 25.631  35.289  1    33.01  ? 88  LYS C CG  1 
ATOM   5253 C  CD  . LYS C 1 92  ? -42.196 26.611  35.627  1    44.82  ? 88  LYS C CD  1 
ATOM   5254 C  CE  . LYS C 1 92  ? -43.569 25.982  35.685  1    53.4   ? 88  LYS C CE  1 
ATOM   5255 N  NZ  . LYS C 1 92  ? -44.624 26.905  36.128  1    51.19  ? 88  LYS C NZ  1 
ATOM   5256 N  N   . LYS C 1 93  ? -39.473 26.459  32.161  1    32.32  ? 89  LYS C N   1 
ATOM   5257 C  CA  . LYS C 1 93  ? -38.525 27.539  31.967  1    31.86  ? 89  LYS C CA  1 
ATOM   5258 C  C   . LYS C 1 93  ? -39.032 28.468  30.868  1    28.37  ? 89  LYS C C   1 
ATOM   5259 O  O   . LYS C 1 93  ? -38.87  29.678  30.992  1    26.82  ? 89  LYS C O   1 
ATOM   5260 C  CB  . LYS C 1 93  ? -37.13  26.983  31.657  1    34.31  ? 89  LYS C CB  1 
ATOM   5261 C  CG  . LYS C 1 93  ? -36.186 26.792  32.846  1    41.22  ? 89  LYS C CG  1 
ATOM   5262 C  CD  . LYS C 1 93  ? -34.749 26.914  32.327  1    63.48  ? 89  LYS C CD  1 
ATOM   5263 C  CE  . LYS C 1 93  ? -33.545 26.81   33.21   1    63.6   ? 89  LYS C CE  1 
ATOM   5264 N  NZ  . LYS C 1 93  ? -33.565 25.465  33.774  1    67.87  ? 89  LYS C NZ  1 
ATOM   5265 N  N   . PHE C 1 94  ? -39.628 27.878  29.813  1    27.52  ? 90  PHE C N   1 
ATOM   5266 C  CA  . PHE C 1 94  ? -40.152 28.584  28.649  1    28.13  ? 90  PHE C CA  1 
ATOM   5267 C  C   . PHE C 1 94  ? -41.324 29.478  29.06   1    30.35  ? 90  PHE C C   1 
ATOM   5268 O  O   . PHE C 1 94  ? -41.367 30.672  28.711  1    31.55  ? 90  PHE C O   1 
ATOM   5269 C  CB  . PHE C 1 94  ? -40.566 27.626  27.528  1    24     ? 90  PHE C CB  1 
ATOM   5270 C  CG  . PHE C 1 94  ? -41.114 28.313  26.286  1    27.79  ? 90  PHE C CG  1 
ATOM   5271 C  CD1 . PHE C 1 94  ? -40.317 29.198  25.545  1    29.78  ? 90  PHE C CD1 1 
ATOM   5272 C  CD2 . PHE C 1 94  ? -42.433 28.09   25.855  1    28.01  ? 90  PHE C CD2 1 
ATOM   5273 C  CE1 . PHE C 1 94  ? -40.828 29.844  24.413  1    29.44  ? 90  PHE C CE1 1 
ATOM   5274 C  CE2 . PHE C 1 94  ? -42.94  28.715  24.711  1    26.62  ? 90  PHE C CE2 1 
ATOM   5275 C  CZ  . PHE C 1 94  ? -42.141 29.597  23.997  1    28.24  ? 90  PHE C CZ  1 
ATOM   5276 N  N   . MET C 1 95  ? -42.26  28.874  29.803  1    29.62  ? 91  MET C N   1 
ATOM   5277 C  CA  . MET C 1 95  ? -43.397 29.597  30.355  1    32.65  ? 91  MET C CA  1 
ATOM   5278 C  C   . MET C 1 95  ? -42.9   30.841  31.092  1    32.96  ? 91  MET C C   1 
ATOM   5279 O  O   . MET C 1 95  ? -43.304 31.945  30.746  1    34.29  ? 91  MET C O   1 
ATOM   5280 C  CB  . MET C 1 95  ? -44.306 28.696  31.2    1    26.76  ? 91  MET C CB  1 
ATOM   5281 C  CG  . MET C 1 95  ? -45.294 27.902  30.368  1    30.21  ? 91  MET C CG  1 
ATOM   5282 S  SD  . MET C 1 95  ? -46.252 26.611  31.206  1    46.28  ? 91  MET C SD  1 
ATOM   5283 C  CE  . MET C 1 95  ? -45.071 25.948  32.375  1    40.26  ? 91  MET C CE  1 
ATOM   5284 N  N   . ASP C 1 96  ? -41.989 30.657  32.058  1    32.2   ? 92  ASP C N   1 
ATOM   5285 C  CA  . ASP C 1 96  ? -41.479 31.736  32.898  1    31.88  ? 92  ASP C CA  1 
ATOM   5286 C  C   . ASP C 1 96  ? -40.868 32.835  32.027  1    32.69  ? 92  ASP C C   1 
ATOM   5287 O  O   . ASP C 1 96  ? -41.005 34.028  32.317  1    31.52  ? 92  ASP C O   1 
ATOM   5288 C  CB  . ASP C 1 96  ? -40.507 31.231  33.955  1    31.8   ? 92  ASP C CB  1 
ATOM   5289 C  CG  . ASP C 1 96  ? -41.097 30.328  35.028  1    37.76  ? 92  ASP C CG  1 
ATOM   5290 O  OD1 . ASP C 1 96  ? -42.344 30.243  35.1    1    38.32  ? 92  ASP C OD1 1 
ATOM   5291 O  OD2 . ASP C 1 96  ? -40.31  29.686  35.764  1    41.2   ? 92  ASP C OD2 1 
ATOM   5292 N  N   . ALA C 1 97  ? -40.19  32.441  30.944  1    29.44  ? 93  ALA C N   1 
ATOM   5293 C  CA  . ALA C 1 97  ? -39.535 33.45   30.134  1    27.9   ? 93  ALA C CA  1 
ATOM   5294 C  C   . ALA C 1 97  ? -40.603 34.26   29.412  1    28.72  ? 93  ALA C C   1 
ATOM   5295 O  O   . ALA C 1 97  ? -40.355 35.394  29.042  1    34.39  ? 93  ALA C O   1 
ATOM   5296 C  CB  . ALA C 1 97  ? -38.574 32.803  29.172  1    24.89  ? 93  ALA C CB  1 
ATOM   5297 N  N   . SER C 1 98  ? -41.784 33.667  29.22   1    31.89  ? 94  SER C N   1 
ATOM   5298 C  CA  . SER C 1 98  ? -42.868 34.252  28.443  1    35.97  ? 94  SER C CA  1 
ATOM   5299 C  C   . SER C 1 98  ? -43.988 34.762  29.352  1    38.24  ? 94  SER C C   1 
ATOM   5300 O  O   . SER C 1 98  ? -45.097 35.014  28.881  1    40.56  ? 94  SER C O   1 
ATOM   5301 C  CB  . SER C 1 98  ? -43.433 33.241  27.446  1    35.64  ? 94  SER C CB  1 
ATOM   5302 O  OG  . SER C 1 98  ? -42.409 32.518  26.781  1    37.16  ? 94  SER C OG  1 
ATOM   5303 N  N   . ALA C 1 99  ? -43.717 34.909  30.654  1    39.32  ? 95  ALA C N   1 
ATOM   5304 C  CA  . ALA C 1 99  ? -44.718 35.388  31.604  1    41.96  ? 95  ALA C CA  1 
ATOM   5305 C  C   . ALA C 1 99  ? -45.32  36.744  31.192  1    41.06  ? 95  ALA C C   1 
ATOM   5306 O  O   . ALA C 1 99  ? -46.529 36.954  31.334  1    36.65  ? 95  ALA C O   1 
ATOM   5307 C  CB  . ALA C 1 99  ? -44.103 35.46   32.977  1    46.2   ? 95  ALA C CB  1 
ATOM   5308 N  N   . LEU C 1 100 ? -44.474 37.65   30.679  1    37.4   ? 96  LEU C N   1 
ATOM   5309 C  CA  . LEU C 1 100 ? -44.911 38.966  30.244  1    39.53  ? 96  LEU C CA  1 
ATOM   5310 C  C   . LEU C 1 100 ? -45.354 38.938  28.777  1    45.47  ? 96  LEU C C   1 
ATOM   5311 O  O   . LEU C 1 100 ? -46.411 39.48   28.465  1    53.75  ? 96  LEU C O   1 
ATOM   5312 C  CB  . LEU C 1 100 ? -43.817 39.998  30.509  1    34.93  ? 96  LEU C CB  1 
ATOM   5313 C  CG  . LEU C 1 100 ? -43.208 39.943  31.911  1    34.26  ? 96  LEU C CG  1 
ATOM   5314 C  CD1 . LEU C 1 100 ? -42.227 41.046  32.191  1    32.9   ? 96  LEU C CD1 1 
ATOM   5315 C  CD2 . LEU C 1 100 ? -44.287 39.951  32.973  1    33.23  ? 96  LEU C CD2 1 
ATOM   5316 N  N   . THR C 1 101 ? -44.568 38.316  27.879  1    42.26  ? 97  THR C N   1 
ATOM   5317 C  CA  . THR C 1 101 ? -44.858 38.347  26.441  1    41.07  ? 97  THR C CA  1 
ATOM   5318 C  C   . THR C 1 101 ? -46.041 37.456  26.075  1    37.15  ? 97  THR C C   1 
ATOM   5319 O  O   . THR C 1 101 ? -46.658 37.672  25.045  1    40.32  ? 97  THR C O   1 
ATOM   5320 C  CB  . THR C 1 101 ? -43.705 37.941  25.517  1    39.85  ? 97  THR C CB  1 
ATOM   5321 O  OG1 . THR C 1 101 ? -43.597 36.519  25.575  1    42.88  ? 97  THR C OG1 1 
ATOM   5322 C  CG2 . THR C 1 101 ? -42.409 38.66   25.821  1    40.92  ? 97  THR C CG2 1 
ATOM   5323 N  N   . GLY C 1 102 ? -46.3   36.4    26.845  1    35.16  ? 98  GLY C N   1 
ATOM   5324 C  CA  . GLY C 1 102 ? -47.24  35.381  26.405  1    33.33  ? 98  GLY C CA  1 
ATOM   5325 C  C   . GLY C 1 102 ? -46.602 34.404  25.409  1    33.97  ? 98  GLY C C   1 
ATOM   5326 O  O   . GLY C 1 102 ? -45.576 34.69   24.787  1    29.47  ? 98  GLY C O   1 
ATOM   5327 N  N   . ILE C 1 103 ? -47.234 33.23   25.298  1    34.34  ? 99  ILE C N   1 
ATOM   5328 C  CA  . ILE C 1 103 ? -46.959 32.236  24.275  1    37.05  ? 99  ILE C CA  1 
ATOM   5329 C  C   . ILE C 1 103 ? -48.03  32.363  23.187  1    36.7   ? 99  ILE C C   1 
ATOM   5330 O  O   . ILE C 1 103 ? -49.223 32.258  23.464  1    42.58  ? 99  ILE C O   1 
ATOM   5331 C  CB  . ILE C 1 103 ? -46.975 30.823  24.897  1    34.63  ? 99  ILE C CB  1 
ATOM   5332 C  CG1 . ILE C 1 103 ? -46.084 30.724  26.137  1    31.71  ? 99  ILE C CG1 1 
ATOM   5333 C  CG2 . ILE C 1 103 ? -46.648 29.746  23.856  1    32.88  ? 99  ILE C CG2 1 
ATOM   5334 C  CD1 . ILE C 1 103 ? -46.149 29.368  26.817  1    28.26  ? 99  ILE C CD1 1 
ATOM   5335 N  N   . PRO C 1 104 ? -47.657 32.561  21.906  1    34.12  ? 100 PRO C N   1 
ATOM   5336 C  CA  . PRO C 1 104 ? -48.65  32.663  20.838  1    30.94  ? 100 PRO C CA  1 
ATOM   5337 C  C   . PRO C 1 104 ? -49.543 31.43   20.762  1    32.66  ? 100 PRO C C   1 
ATOM   5338 O  O   . PRO C 1 104 ? -49.064 30.304  20.901  1    28.35  ? 100 PRO C O   1 
ATOM   5339 C  CB  . PRO C 1 104 ? -47.778 32.798  19.579  1    33.97  ? 100 PRO C CB  1 
ATOM   5340 C  CG  . PRO C 1 104 ? -46.438 33.316  20.067  1    32.58  ? 100 PRO C CG  1 
ATOM   5341 C  CD  . PRO C 1 104 ? -46.268 32.674  21.427  1    36.14  ? 100 PRO C CD  1 
ATOM   5342 N  N   . LEU C 1 105 ? -50.84  31.663  20.512  1    37.64  ? 101 LEU C N   1 
ATOM   5343 C  CA  . LEU C 1 105 ? -51.856 30.616  20.416  1    44.98  ? 101 LEU C CA  1 
ATOM   5344 C  C   . LEU C 1 105 ? -51.49  29.515  19.402  1    42.64  ? 101 LEU C C   1 
ATOM   5345 O  O   . LEU C 1 105 ? -51.745 28.34   19.66   1    39.8   ? 101 LEU C O   1 
ATOM   5346 C  CB  . LEU C 1 105 ? -53.217 31.27   20.162  1    52.95  ? 101 LEU C CB  1 
ATOM   5347 C  CG  . LEU C 1 105 ? -54.477 30.389  20.202  1    58.76  ? 101 LEU C CG  1 
ATOM   5348 C  CD1 . LEU C 1 105 ? -54.704 29.603  18.907  1    60.56  ? 101 LEU C CD1 1 
ATOM   5349 C  CD2 . LEU C 1 105 ? -54.492 29.456  21.407  1    58.83  ? 101 LEU C CD2 1 
ATOM   5350 N  N   . PRO C 1 106 ? -50.916 29.81   18.21   1    42.63  ? 102 PRO C N   1 
ATOM   5351 C  CA  . PRO C 1 106 ? -50.46  28.747  17.313  1    39.5   ? 102 PRO C CA  1 
ATOM   5352 C  C   . PRO C 1 106 ? -49.462 27.769  17.921  1    35.52  ? 102 PRO C C   1 
ATOM   5353 O  O   . PRO C 1 106 ? -49.487 26.586  17.585  1    38.71  ? 102 PRO C O   1 
ATOM   5354 C  CB  . PRO C 1 106 ? -49.868 29.488  16.096  1    39.1   ? 102 PRO C CB  1 
ATOM   5355 C  CG  . PRO C 1 106 ? -50.589 30.802  16.106  1    36.94  ? 102 PRO C CG  1 
ATOM   5356 C  CD  . PRO C 1 106 ? -50.782 31.138  17.586  1    41.18  ? 102 PRO C CD  1 
ATOM   5357 N  N   . LEU C 1 107 ? -48.561 28.278  18.77   1    32.52  ? 103 LEU C N   1 
ATOM   5358 C  CA  . LEU C 1 107 ? -47.52  27.449  19.371  1    29.07  ? 103 LEU C CA  1 
ATOM   5359 C  C   . LEU C 1 107 ? -48.122 26.575  20.47   1    27.25  ? 103 LEU C C   1 
ATOM   5360 O  O   . LEU C 1 107 ? -47.838 25.381  20.537  1    25.04  ? 103 LEU C O   1 
ATOM   5361 C  CB  . LEU C 1 107 ? -46.381 28.325  19.894  1    28.78  ? 103 LEU C CB  1 
ATOM   5362 C  CG  . LEU C 1 107 ? -45.135 27.605  20.415  1    28.75  ? 103 LEU C CG  1 
ATOM   5363 C  CD1 . LEU C 1 107 ? -44.53  26.725  19.339  1    27.61  ? 103 LEU C CD1 1 
ATOM   5364 C  CD2 . LEU C 1 107 ? -44.108 28.622  20.917  1    28.5   ? 103 LEU C CD2 1 
ATOM   5365 N  N   . ILE C 1 108 ? -48.994 27.175  21.294  1    25.59  ? 104 ILE C N   1 
ATOM   5366 C  CA  . ILE C 1 108 ? -49.713 26.437  22.318  1    26.31  ? 104 ILE C CA  1 
ATOM   5367 C  C   . ILE C 1 108 ? -50.404 25.237  21.682  1    30.95  ? 104 ILE C C   1 
ATOM   5368 O  O   . ILE C 1 108 ? -50.326 24.112  22.196  1    31.76  ? 104 ILE C O   1 
ATOM   5369 C  CB  . ILE C 1 108 ? -50.728 27.326  23.057  1    26.17  ? 104 ILE C CB  1 
ATOM   5370 C  CG1 . ILE C 1 108 ? -50.047 28.533  23.733  1    26.24  ? 104 ILE C CG1 1 
ATOM   5371 C  CG2 . ILE C 1 108 ? -51.542 26.491  24.05   1    23.93  ? 104 ILE C CG2 1 
ATOM   5372 C  CD1 . ILE C 1 108 ? -51.005 29.559  24.313  1    24.65  ? 104 ILE C CD1 1 
ATOM   5373 N  N   . LYS C 1 109 ? -51.077 25.499  20.556  1    30.13  ? 105 LYS C N   1 
ATOM   5374 C  CA  . LYS C 1 109 ? -51.805 24.457  19.858  1    30.56  ? 105 LYS C CA  1 
ATOM   5375 C  C   . LYS C 1 109 ? -50.826 23.393  19.354  1    32.53  ? 105 LYS C C   1 
ATOM   5376 O  O   . LYS C 1 109 ? -51.067 22.192  19.507  1    33.24  ? 105 LYS C O   1 
ATOM   5377 C  CB  . LYS C 1 109 ? -52.603 25.101  18.723  1    28.75  ? 105 LYS C CB  1 
ATOM   5378 C  CG  . LYS C 1 109 ? -53.438 24.142  17.904  1    28.8   ? 105 LYS C CG  1 
ATOM   5379 C  CD  . LYS C 1 109 ? -54.283 24.905  16.896  1    31.91  ? 105 LYS C CD  1 
ATOM   5380 C  CE  . LYS C 1 109 ? -55.246 25.92   17.483  1    27.92  ? 105 LYS C CE  1 
ATOM   5381 N  NZ  . LYS C 1 109 ? -55.979 26.609  16.419  1    25.52  ? 105 LYS C NZ  1 
ATOM   5382 N  N   . SER C 1 110 ? -49.713 23.847  18.759  1    31.23  ? 106 SER C N   1 
ATOM   5383 C  CA  . SER C 1 110 ? -48.699 22.925  18.288  1    29.28  ? 106 SER C CA  1 
ATOM   5384 C  C   . SER C 1 110 ? -48.212 22.069  19.453  1    29.88  ? 106 SER C C   1 
ATOM   5385 O  O   . SER C 1 110 ? -48.129 20.851  19.325  1    28.28  ? 106 SER C O   1 
ATOM   5386 C  CB  . SER C 1 110 ? -47.558 23.636  17.611  1    32.02  ? 106 SER C CB  1 
ATOM   5387 O  OG  . SER C 1 110 ? -46.523 22.711  17.291  1    35.36  ? 106 SER C OG  1 
ATOM   5388 N  N   . TYR C 1 111 ? -47.927 22.707  20.596  1    27.58  ? 107 TYR C N   1 
ATOM   5389 C  CA  . TYR C 1 111 ? -47.299 21.989  21.692  1    30.81  ? 107 TYR C CA  1 
ATOM   5390 C  C   . TYR C 1 111 ? -48.253 20.938  22.259  1    30.92  ? 107 TYR C C   1 
ATOM   5391 O  O   . TYR C 1 111 ? -47.828 19.831  22.575  1    39.4   ? 107 TYR C O   1 
ATOM   5392 C  CB  . TYR C 1 111 ? -46.759 22.939  22.767  1    32.33  ? 107 TYR C CB  1 
ATOM   5393 C  CG  . TYR C 1 111 ? -45.413 23.595  22.512  1    28.48  ? 107 TYR C CG  1 
ATOM   5394 C  CD1 . TYR C 1 111 ? -44.563 23.178  21.482  1    27.9   ? 107 TYR C CD1 1 
ATOM   5395 C  CD2 . TYR C 1 111 ? -44.985 24.622  23.341  1    27.39  ? 107 TYR C CD2 1 
ATOM   5396 C  CE1 . TYR C 1 111 ? -43.311 23.754  21.299  1    29.79  ? 107 TYR C CE1 1 
ATOM   5397 C  CE2 . TYR C 1 111 ? -43.751 25.221  23.144  1    29.77  ? 107 TYR C CE2 1 
ATOM   5398 C  CZ  . TYR C 1 111 ? -42.908 24.787  22.133  1    32.43  ? 107 TYR C CZ  1 
ATOM   5399 O  OH  . TYR C 1 111 ? -41.703 25.418  21.972  1    36.36  ? 107 TYR C OH  1 
ATOM   5400 N  N   . LEU C 1 112 ? -49.536 21.282  22.389  1    31.3   ? 108 LEU C N   1 
ATOM   5401 C  CA  . LEU C 1 112 ? -50.517 20.38   22.962  1    31.95  ? 108 LEU C CA  1 
ATOM   5402 C  C   . LEU C 1 112 ? -50.732 19.199  22.022  1    34.63  ? 108 LEU C C   1 
ATOM   5403 O  O   . LEU C 1 112 ? -50.846 18.06   22.465  1    37.64  ? 108 LEU C O   1 
ATOM   5404 C  CB  . LEU C 1 112 ? -51.814 21.148  23.208  1    37.14  ? 108 LEU C CB  1 
ATOM   5405 C  CG  . LEU C 1 112 ? -52.963 20.353  23.84   1    40.6   ? 108 LEU C CG  1 
ATOM   5406 C  CD1 . LEU C 1 112 ? -52.564 19.761  25.169  1    40.88  ? 108 LEU C CD1 1 
ATOM   5407 C  CD2 . LEU C 1 112 ? -54.18  21.222  24.034  1    36.28  ? 108 LEU C CD2 1 
ATOM   5408 N  N   . PHE C 1 113 ? -50.736 19.473  20.715  1    35.72  ? 109 PHE C N   1 
ATOM   5409 C  CA  . PHE C 1 113 ? -50.901 18.429  19.704  1    39.58  ? 109 PHE C CA  1 
ATOM   5410 C  C   . PHE C 1 113 ? -49.771 17.392  19.775  1    37     ? 109 PHE C C   1 
ATOM   5411 O  O   . PHE C 1 113 ? -49.987 16.19   19.629  1    35.43  ? 109 PHE C O   1 
ATOM   5412 C  CB  . PHE C 1 113 ? -50.976 19.099  18.325  1    37.88  ? 109 PHE C CB  1 
ATOM   5413 C  CG  . PHE C 1 113 ? -51.407 18.208  17.181  1    34.76  ? 109 PHE C CG  1 
ATOM   5414 C  CD1 . PHE C 1 113 ? -52.66  17.603  17.199  1    35.62  ? 109 PHE C CD1 1 
ATOM   5415 C  CD2 . PHE C 1 113 ? -50.559 17.994  16.091  1    40.69  ? 109 PHE C CD2 1 
ATOM   5416 C  CE1 . PHE C 1 113 ? -53.059 16.798  16.134  1    41.61  ? 109 PHE C CE1 1 
ATOM   5417 C  CE2 . PHE C 1 113 ? -50.956 17.176  15.028  1    44.03  ? 109 PHE C CE2 1 
ATOM   5418 C  CZ  . PHE C 1 113 ? -52.208 16.577  15.046  1    39.92  ? 109 PHE C CZ  1 
ATOM   5419 N  N   . GLN C 1 114 ? -48.549 17.87   19.999  1    37.28  ? 110 GLN C N   1 
ATOM   5420 C  CA  . GLN C 1 114 ? -47.392 16.998  20.076  1    38.31  ? 110 GLN C CA  1 
ATOM   5421 C  C   . GLN C 1 114 ? -47.415 16.2    21.375  1    35.02  ? 110 GLN C C   1 
ATOM   5422 O  O   . GLN C 1 114 ? -47.122 15.01   21.372  1    32.96  ? 110 GLN C O   1 
ATOM   5423 C  CB  . GLN C 1 114 ? -46.121 17.826  19.913  1    39.01  ? 110 GLN C CB  1 
ATOM   5424 C  CG  . GLN C 1 114 ? -45.92  18.36   18.497  1    33.04  ? 110 GLN C CG  1 
ATOM   5425 C  CD  . GLN C 1 114 ? -44.624 19.124  18.381  1    36.81  ? 110 GLN C CD  1 
ATOM   5426 O  OE1 . GLN C 1 114 ? -43.539 18.534  18.51   1    42.34  ? 110 GLN C OE1 1 
ATOM   5427 N  NE2 . GLN C 1 114 ? -44.731 20.443  18.223  1    30.49  ? 110 GLN C NE2 1 
ATOM   5428 N  N   . LEU C 1 115 ? -47.768 16.86   22.482  1    36.62  ? 111 LEU C N   1 
ATOM   5429 C  CA  . LEU C 1 115 ? -47.821 16.205  23.784  1    35.29  ? 111 LEU C CA  1 
ATOM   5430 C  C   . LEU C 1 115 ? -48.838 15.066  23.739  1    35.48  ? 111 LEU C C   1 
ATOM   5431 O  O   . LEU C 1 115 ? -48.644 14.038  24.377  1    34.78  ? 111 LEU C O   1 
ATOM   5432 C  CB  . LEU C 1 115 ? -48.171 17.234  24.858  1    29.5   ? 111 LEU C CB  1 
ATOM   5433 C  CG  . LEU C 1 115 ? -47.108 18.286  25.16   1    27.14  ? 111 LEU C CG  1 
ATOM   5434 C  CD1 . LEU C 1 115 ? -47.658 19.297  26.139  1    23.24  ? 111 LEU C CD1 1 
ATOM   5435 C  CD2 . LEU C 1 115 ? -45.853 17.615  25.724  1    27.44  ? 111 LEU C CD2 1 
ATOM   5436 N  N   . LEU C 1 116 ? -49.921 15.263  22.977  1    30.4   ? 112 LEU C N   1 
ATOM   5437 C  CA  . LEU C 1 116 ? -50.974 14.273  22.921  1    33.96  ? 112 LEU C CA  1 
ATOM   5438 C  C   . LEU C 1 116 ? -50.573 13.078  22.051  1    38.98  ? 112 LEU C C   1 
ATOM   5439 O  O   . LEU C 1 116 ? -50.967 11.944  22.334  1    40.38  ? 112 LEU C O   1 
ATOM   5440 C  CB  . LEU C 1 116 ? -52.204 14.97   22.366  1    33.58  ? 112 LEU C CB  1 
ATOM   5441 C  CG  . LEU C 1 116 ? -52.933 15.872  23.353  1    34.87  ? 112 LEU C CG  1 
ATOM   5442 C  CD1 . LEU C 1 116 ? -53.904 16.773  22.621  1    32.67  ? 112 LEU C CD1 1 
ATOM   5443 C  CD2 . LEU C 1 116 ? -53.647 14.994  24.365  1    33.65  ? 112 LEU C CD2 1 
ATOM   5444 N  N   . GLN C 1 117 ? -49.851 13.346  20.953  1    36.62  ? 113 GLN C N   1 
ATOM   5445 C  CA  . GLN C 1 117 ? -49.341 12.294  20.091  1    35.34  ? 113 GLN C CA  1 
ATOM   5446 C  C   . GLN C 1 117 ? -48.336 11.455  20.876  1    36.74  ? 113 GLN C C   1 
ATOM   5447 O  O   . GLN C 1 117 ? -48.372 10.225  20.845  1    35.79  ? 113 GLN C O   1 
ATOM   5448 C  CB  . GLN C 1 117 ? -48.657 12.926  18.876  1    40.35  ? 113 GLN C CB  1 
ATOM   5449 C  CG  . GLN C 1 117 ? -49.609 13.6    17.898  1    39.66  ? 113 GLN C CG  1 
ATOM   5450 C  CD  . GLN C 1 117 ? -48.902 14.03   16.637  1    45.68  ? 113 GLN C CD  1 
ATOM   5451 O  OE1 . GLN C 1 117 ? -49.179 13.525  15.55   1    57.04  ? 113 GLN C OE1 1 
ATOM   5452 N  NE2 . GLN C 1 117 ? -47.973 14.962  16.761  1    52.42  ? 113 GLN C NE2 1 
ATOM   5453 N  N   . GLY C 1 118 ? -47.425 12.152  21.565  1    35.25  ? 114 GLY C N   1 
ATOM   5454 C  CA  . GLY C 1 118 ? -46.501 11.526  22.485  1    36.36  ? 114 GLY C CA  1 
ATOM   5455 C  C   . GLY C 1 118 ? -47.226 10.613  23.471  1    34.76  ? 114 GLY C C   1 
ATOM   5456 O  O   . GLY C 1 118 ? -46.815 9.463   23.69   1    32.49  ? 114 GLY C O   1 
ATOM   5457 N  N   . LEU C 1 119 ? -48.306 11.142  24.058  1    34.04  ? 115 LEU C N   1 
ATOM   5458 C  CA  . LEU C 1 119 ? -48.943 10.479  25.186  1    34.21  ? 115 LEU C CA  1 
ATOM   5459 C  C   . LEU C 1 119 ? -49.753 9.273   24.7    1    30.73  ? 115 LEU C C   1 
ATOM   5460 O  O   . LEU C 1 119 ? -49.799 8.247   25.37   1    26.64  ? 115 LEU C O   1 
ATOM   5461 C  CB  . LEU C 1 119 ? -49.766 11.472  26.01   1    27.21  ? 115 LEU C CB  1 
ATOM   5462 C  CG  . LEU C 1 119 ? -50.495 10.833  27.19   1    28.23  ? 115 LEU C CG  1 
ATOM   5463 C  CD1 . LEU C 1 119 ? -49.509 10.182  28.167  1    26.97  ? 115 LEU C CD1 1 
ATOM   5464 C  CD2 . LEU C 1 119 ? -51.383 11.849  27.867  1    31.89  ? 115 LEU C CD2 1 
ATOM   5465 N  N   . ALA C 1 120 ? -50.392 9.449   23.535  1    30.86  ? 116 ALA C N   1 
ATOM   5466 C  CA  . ALA C 1 120 ? -51.167 8.43    22.842  1    31.61  ? 116 ALA C CA  1 
ATOM   5467 C  C   . ALA C 1 120 ? -50.281 7.215   22.58   1    32.28  ? 116 ALA C C   1 
ATOM   5468 O  O   . ALA C 1 120 ? -50.702 6.073   22.758  1    30     ? 116 ALA C O   1 
ATOM   5469 C  CB  . ALA C 1 120 ? -51.731 9.022   21.554  1    24.75  ? 116 ALA C CB  1 
ATOM   5470 N  N   . PHE C 1 121 ? -49.04  7.502   22.173  1    35.36  ? 117 PHE C N   1 
ATOM   5471 C  CA  . PHE C 1 121 ? -48.036 6.49    21.911  1    34.87  ? 117 PHE C CA  1 
ATOM   5472 C  C   . PHE C 1 121 ? -47.68  5.75    23.194  1    36.27  ? 117 PHE C C   1 
ATOM   5473 O  O   . PHE C 1 121 ? -47.521 4.531   23.151  1    42.28  ? 117 PHE C O   1 
ATOM   5474 C  CB  . PHE C 1 121 ? -46.792 7.122   21.295  1    32.77  ? 117 PHE C CB  1 
ATOM   5475 C  CG  . PHE C 1 121 ? -45.866 6.081   20.679  1    36.01  ? 117 PHE C CG  1 
ATOM   5476 C  CD1 . PHE C 1 121 ? -44.95  5.378   21.47   1    28.75  ? 117 PHE C CD1 1 
ATOM   5477 C  CD2 . PHE C 1 121 ? -45.927 5.801   19.309  1    30.83  ? 117 PHE C CD2 1 
ATOM   5478 C  CE1 . PHE C 1 121 ? -44.103 4.451   20.887  1    28.51  ? 117 PHE C CE1 1 
ATOM   5479 C  CE2 . PHE C 1 121 ? -45.076 4.869   18.739  1    27.84  ? 117 PHE C CE2 1 
ATOM   5480 C  CZ  . PHE C 1 121 ? -44.187 4.186   19.53   1    29.17  ? 117 PHE C CZ  1 
ATOM   5481 N  N   . CYS C 1 122 ? -47.532 6.479   24.311  1    31.4   ? 118 CYS C N   1 
ATOM   5482 C  CA  . CYS C 1 122 ? -47.326 5.822   25.594  1    31.73  ? 118 CYS C CA  1 
ATOM   5483 C  C   . CYS C 1 122 ? -48.465 4.853   25.883  1    33.68  ? 118 CYS C C   1 
ATOM   5484 O  O   . CYS C 1 122 ? -48.21  3.665   26.091  1    35.64  ? 118 CYS C O   1 
ATOM   5485 C  CB  . CYS C 1 122 ? -47.187 6.802   26.741  1    28.82  ? 118 CYS C CB  1 
ATOM   5486 S  SG  . CYS C 1 122 ? -45.661 7.76    26.594  1    39.84  ? 118 CYS C SG  1 
ATOM   5487 N  N   . HIS C 1 123 ? -49.705 5.369   25.851  1    33.28  ? 119 HIS C N   1 
ATOM   5488 C  CA  . HIS C 1 123 ? -50.892 4.624   26.239  1    31.37  ? 119 HIS C CA  1 
ATOM   5489 C  C   . HIS C 1 123 ? -51.103 3.42    25.317  1    34.72  ? 119 HIS C C   1 
ATOM   5490 O  O   . HIS C 1 123 ? -51.421 2.332   25.79   1    36.74  ? 119 HIS C O   1 
ATOM   5491 C  CB  . HIS C 1 123 ? -52.073 5.576   26.363  1    29.94  ? 119 HIS C CB  1 
ATOM   5492 C  CG  . HIS C 1 123 ? -51.924 6.545   27.487  1    33.55  ? 119 HIS C CG  1 
ATOM   5493 N  ND1 . HIS C 1 123 ? -52.734 7.651   27.614  1    34.41  ? 119 HIS C ND1 1 
ATOM   5494 C  CD2 . HIS C 1 123 ? -51.097 6.583   28.546  1    39.08  ? 119 HIS C CD2 1 
ATOM   5495 C  CE1 . HIS C 1 123 ? -52.394 8.337   28.696  1    36.14  ? 119 HIS C CE1 1 
ATOM   5496 N  NE2 . HIS C 1 123 ? -51.39  7.714   29.269  1    41.65  ? 119 HIS C NE2 1 
ATOM   5497 N  N   . SER C 1 124 ? -50.909 3.632   24.006  1    34.41  ? 120 SER C N   1 
ATOM   5498 C  CA  . SER C 1 124 ? -50.869 2.59    22.989  1    31.69  ? 120 SER C CA  1 
ATOM   5499 C  C   . SER C 1 124 ? -49.88  1.481   23.349  1    34.33  ? 120 SER C C   1 
ATOM   5500 O  O   . SER C 1 124 ? -50.011 0.369   22.843  1    31.48  ? 120 SER C O   1 
ATOM   5501 C  CB  . SER C 1 124 ? -50.491 3.163   21.654  1    30.38  ? 120 SER C CB  1 
ATOM   5502 O  OG  . SER C 1 124 ? -51.592 3.836   21.072  1    42.25  ? 120 SER C OG  1 
ATOM   5503 N  N   . HIS C 1 125 ? -48.85  1.81    24.147  1    33.48  ? 121 HIS C N   1 
ATOM   5504 C  CA  . HIS C 1 125 ? -47.8   0.856   24.47   1    32.03  ? 121 HIS C CA  1 
ATOM   5505 C  C   . HIS C 1 125 ? -47.812 0.554   25.953  1    28     ? 121 HIS C C   1 
ATOM   5506 O  O   . HIS C 1 125 ? -46.767 0.348   26.518  1    28.34  ? 121 HIS C O   1 
ATOM   5507 C  CB  . HIS C 1 125 ? -46.439 1.337   23.964  1    32.79  ? 121 HIS C CB  1 
ATOM   5508 C  CG  . HIS C 1 125 ? -46.393 1.487   22.485  1    42.31  ? 121 HIS C CG  1 
ATOM   5509 N  ND1 . HIS C 1 125 ? -47.06  2.504   21.823  1    49.03  ? 121 HIS C ND1 1 
ATOM   5510 C  CD2 . HIS C 1 125 ? -45.824 0.737   21.534  1    44.61  ? 121 HIS C CD2 1 
ATOM   5511 C  CE1 . HIS C 1 125 ? -46.853 2.394   20.517  1    46.81  ? 121 HIS C CE1 1 
ATOM   5512 N  NE2 . HIS C 1 125 ? -46.104 1.329   20.324  1    53.83  ? 121 HIS C NE2 1 
ATOM   5513 N  N   . ARG C 1 126 ? -48.949 0.452   26.563  1    31.98  ? 122 ARG C N   1 
ATOM   5514 C  CA  . ARG C 1 126 ? -49.118 0.067   27.992  1    30.78  ? 122 ARG C CA  1 
ATOM   5515 C  C   . ARG C 1 126 ? -48.158 0.786   28.957  1    34.23  ? 122 ARG C C   1 
ATOM   5516 O  O   . ARG C 1 126 ? -47.743 0.133   29.912  1    34.26  ? 122 ARG C O   1 
ATOM   5517 C  CB  . ARG C 1 126 ? -49.076 -1.454  28.191  1    29.76  ? 122 ARG C CB  1 
ATOM   5518 C  CG  . ARG C 1 126 ? -48.274 -2.373  27.283  1    31.2   ? 122 ARG C CG  1 
ATOM   5519 C  CD  . ARG C 1 126 ? -47.391 -3.274  28.12   1    29.69  ? 122 ARG C CD  1 
ATOM   5520 N  NE  . ARG C 1 126 ? -46.072 -2.675  28.34   1    35.94  ? 122 ARG C NE  1 
ATOM   5521 C  CZ  . ARG C 1 126 ? -45.13  -2.579  27.415  1    37.42  ? 122 ARG C CZ  1 
ATOM   5522 N  NH1 . ARG C 1 126 ? -44.786 -1.395  26.948  1    30.42  ? 122 ARG C NH1 1 
ATOM   5523 N  NH2 . ARG C 1 126 ? -44.53  -3.663  26.963  1    37.99  ? 122 ARG C NH2 1 
ATOM   5524 N  N   . VAL C 1 127 ? -47.91  2.114   28.754  1    30.88  ? 123 VAL C N   1 
ATOM   5525 C  CA  . VAL C 1 127 ? -47.069 2.852   29.705  1    33.04  ? 123 VAL C CA  1 
ATOM   5526 C  C   . VAL C 1 127 ? -47.83  4.086   30.205  1    32.51  ? 123 VAL C C   1 
ATOM   5527 O  O   . VAL C 1 127 ? -48.189 4.955   29.41   1    34.85  ? 123 VAL C O   1 
ATOM   5528 C  CB  . VAL C 1 127 ? -45.693 3.258   29.103  1    30.11  ? 123 VAL C CB  1 
ATOM   5529 C  CG1 . VAL C 1 127 ? -44.997 4.389   29.853  1    23.59  ? 123 VAL C CG1 1 
ATOM   5530 C  CG2 . VAL C 1 127 ? -44.752 2.08    28.92   1    27.63  ? 123 VAL C CG2 1 
ATOM   5531 N  N   . LEU C 1 128 ? -48.059 4.163   31.519  1    30.9   ? 124 LEU C N   1 
ATOM   5532 C  CA  . LEU C 1 128 ? -48.475 5.406   32.171  1    35.04  ? 124 LEU C CA  1 
ATOM   5533 C  C   . LEU C 1 128 ? -47.236 6.259   32.467  1    36.73  ? 124 LEU C C   1 
ATOM   5534 O  O   . LEU C 1 128 ? -46.231 5.727   32.966  1    37.7   ? 124 LEU C O   1 
ATOM   5535 C  CB  . LEU C 1 128 ? -49.243 5.144   33.471  1    28.55  ? 124 LEU C CB  1 
ATOM   5536 C  CG  . LEU C 1 128 ? -50.48  4.252   33.379  1    28.39  ? 124 LEU C CG  1 
ATOM   5537 C  CD1 . LEU C 1 128 ? -51.072 4.06    34.762  1    27.06  ? 124 LEU C CD1 1 
ATOM   5538 C  CD2 . LEU C 1 128 ? -51.48  4.878   32.429  1    27.11  ? 124 LEU C CD2 1 
ATOM   5539 N  N   . HIS C 1 129 ? -47.337 7.584   32.246  1    32.03  ? 125 HIS C N   1 
ATOM   5540 C  CA  . HIS C 1 129 ? -46.236 8.47    32.587  1    33.12  ? 125 HIS C CA  1 
ATOM   5541 C  C   . HIS C 1 129 ? -46.298 8.84    34.062  1    35.15  ? 125 HIS C C   1 
ATOM   5542 O  O   . HIS C 1 129 ? -45.342 8.632   34.797  1    40.71  ? 125 HIS C O   1 
ATOM   5543 C  CB  . HIS C 1 129 ? -46.221 9.735   31.741  1    31.25  ? 125 HIS C CB  1 
ATOM   5544 C  CG  . HIS C 1 129 ? -45.006 10.581  31.947  1    34.93  ? 125 HIS C CG  1 
ATOM   5545 N  ND1 . HIS C 1 129 ? -44.836 11.433  33.024  1    32.55  ? 125 HIS C ND1 1 
ATOM   5546 C  CD2 . HIS C 1 129 ? -43.918 10.74   31.172  1    36.07  ? 125 HIS C CD2 1 
ATOM   5547 C  CE1 . HIS C 1 129 ? -43.678 12.074  32.898  1    35.13  ? 125 HIS C CE1 1 
ATOM   5548 N  NE2 . HIS C 1 129 ? -43.097 11.671  31.785  1    36.06  ? 125 HIS C NE2 1 
ATOM   5549 N  N   . ARG C 1 130 ? -47.41  9.443   34.469  1    35.18  ? 126 ARG C N   1 
ATOM   5550 C  CA  . ARG C 1 130 ? -47.711 9.639   35.879  1    35.29  ? 126 ARG C CA  1 
ATOM   5551 C  C   . ARG C 1 130 ? -46.895 10.77   36.51   1    31.98  ? 126 ARG C C   1 
ATOM   5552 O  O   . ARG C 1 130 ? -46.932 10.942  37.715  1    35.35  ? 126 ARG C O   1 
ATOM   5553 C  CB  . ARG C 1 130 ? -47.525 8.356   36.705  1    31.81  ? 126 ARG C CB  1 
ATOM   5554 C  CG  . ARG C 1 130 ? -48.307 7.136   36.249  1    28.29  ? 126 ARG C CG  1 
ATOM   5555 C  CD  . ARG C 1 130 ? -48.32  6.062   37.337  1    26.8   ? 126 ARG C CD  1 
ATOM   5556 N  NE  . ARG C 1 130 ? -46.989 5.557   37.689  1    23.47  ? 126 ARG C NE  1 
ATOM   5557 C  CZ  . ARG C 1 130 ? -46.757 4.611   38.588  1    26.24  ? 126 ARG C CZ  1 
ATOM   5558 N  NH1 . ARG C 1 130 ? -47.75  4.031   39.263  1    24.7   ? 126 ARG C NH1 1 
ATOM   5559 N  NH2 . ARG C 1 130 ? -45.506 4.234   38.807  1    25.23  ? 126 ARG C NH2 1 
ATOM   5560 N  N   . ASP C 1 131 ? -46.181 11.565  35.722  1    32.13  ? 127 ASP C N   1 
ATOM   5561 C  CA  . ASP C 1 131 ? -45.539 12.737  36.288  1    32.08  ? 127 ASP C CA  1 
ATOM   5562 C  C   . ASP C 1 131 ? -45.489 13.835  35.225  1    34.17  ? 127 ASP C C   1 
ATOM   5563 O  O   . ASP C 1 131 ? -44.46  14.498  35.062  1    35.51  ? 127 ASP C O   1 
ATOM   5564 C  CB  . ASP C 1 131 ? -44.158 12.423  36.842  1    31.11  ? 127 ASP C CB  1 
ATOM   5565 C  CG  . ASP C 1 131 ? -43.596 13.437  37.834  1    36.34  ? 127 ASP C CG  1 
ATOM   5566 O  OD1 . ASP C 1 131 ? -44.401 14.189  38.466  1    38.15  ? 127 ASP C OD1 1 
ATOM   5567 O  OD2 . ASP C 1 131 ? -42.349 13.484  37.96   1    37.79  ? 127 ASP C OD2 1 
ATOM   5568 N  N   . LEU C 1 132 ? -46.606 14.041  34.517  1    27.07  ? 128 LEU C N   1 
ATOM   5569 C  CA  . LEU C 1 132 ? -46.598 15.054  33.48   1    31.55  ? 128 LEU C CA  1 
ATOM   5570 C  C   . LEU C 1 132 ? -46.742 16.435  34.103  1    33.89  ? 128 LEU C C   1 
ATOM   5571 O  O   . LEU C 1 132 ? -47.752 16.744  34.708  1    43.13  ? 128 LEU C O   1 
ATOM   5572 C  CB  . LEU C 1 132 ? -47.65  14.771  32.41   1    29.9   ? 128 LEU C CB  1 
ATOM   5573 C  CG  . LEU C 1 132 ? -47.354 13.54   31.546  1    30     ? 128 LEU C CG  1 
ATOM   5574 C  CD1 . LEU C 1 132 ? -48.588 13.066  30.822  1    30.01  ? 128 LEU C CD1 1 
ATOM   5575 C  CD2 . LEU C 1 132 ? -46.231 13.787  30.573  1    29.42  ? 128 LEU C CD2 1 
ATOM   5576 N  N   . LYS C 1 133 ? -45.705 17.256  33.967  1    33.18  ? 129 LYS C N   1 
ATOM   5577 C  CA  . LYS C 1 133 ? -45.719 18.63   34.431  1    30.52  ? 129 LYS C CA  1 
ATOM   5578 C  C   . LYS C 1 133 ? -44.72  19.424  33.601  1    29.72  ? 129 LYS C C   1 
ATOM   5579 O  O   . LYS C 1 133 ? -43.826 18.883  32.984  1    30.58  ? 129 LYS C O   1 
ATOM   5580 C  CB  . LYS C 1 133 ? -45.35  18.662  35.914  1    29.77  ? 129 LYS C CB  1 
ATOM   5581 C  CG  . LYS C 1 133 ? -44.033 17.989  36.21   1    33.8   ? 129 LYS C CG  1 
ATOM   5582 C  CD  . LYS C 1 133 ? -43.573 18.176  37.65   1    33.99  ? 129 LYS C CD  1 
ATOM   5583 C  CE  . LYS C 1 133 ? -42.492 17.206  37.974  1    37.64  ? 129 LYS C CE  1 
ATOM   5584 N  NZ  . LYS C 1 133 ? -41.806 17.673  39.179  1    46.24  ? 129 LYS C NZ  1 
ATOM   5585 N  N   . PRO C 1 134 ? -44.818 20.762  33.561  1    36.53  ? 130 PRO C N   1 
ATOM   5586 C  CA  . PRO C 1 134 ? -44.024 21.535  32.595  1    34.08  ? 130 PRO C CA  1 
ATOM   5587 C  C   . PRO C 1 134 ? -42.52  21.271  32.629  1    32.34  ? 130 PRO C C   1 
ATOM   5588 O  O   . PRO C 1 134 ? -41.849 21.348  31.607  1    28.49  ? 130 PRO C O   1 
ATOM   5589 C  CB  . PRO C 1 134 ? -44.337 22.975  32.97   1    34.54  ? 130 PRO C CB  1 
ATOM   5590 C  CG  . PRO C 1 134 ? -45.665 22.892  33.696  1    37.06  ? 130 PRO C CG  1 
ATOM   5591 C  CD  . PRO C 1 134 ? -45.668 21.578  34.45   1    33.11  ? 130 PRO C CD  1 
ATOM   5592 N  N   . GLN C 1 135 ? -42.004 21.009  33.836  1    36.59  ? 131 GLN C N   1 
ATOM   5593 C  CA  . GLN C 1 135 ? -40.587 20.785  34.091  1    33.88  ? 131 GLN C CA  1 
ATOM   5594 C  C   . GLN C 1 135 ? -40.109 19.486  33.436  1    36.29  ? 131 GLN C C   1 
ATOM   5595 O  O   . GLN C 1 135 ? -38.908 19.292  33.331  1    35.78  ? 131 GLN C O   1 
ATOM   5596 C  CB  . GLN C 1 135 ? -40.284 20.633  35.576  1    28.04  ? 131 GLN C CB  1 
ATOM   5597 C  CG  . GLN C 1 135 ? -40.69  21.831  36.429  1    34.85  ? 131 GLN C CG  1 
ATOM   5598 C  CD  . GLN C 1 135 ? -42.164 21.916  36.811  1    41.88  ? 131 GLN C CD  1 
ATOM   5599 O  OE1 . GLN C 1 135 ? -43.053 21.244  36.263  1    40.5   ? 131 GLN C OE1 1 
ATOM   5600 N  NE2 . GLN C 1 135 ? -42.464 22.841  37.716  1    36.8   ? 131 GLN C NE2 1 
ATOM   5601 N  N   . ASN C 1 136 ? -41.043 18.591  33.056  1    31.06  ? 132 ASN C N   1 
ATOM   5602 C  CA  . ASN C 1 136 ? -40.731 17.269  32.544  1    27.63  ? 132 ASN C CA  1 
ATOM   5603 C  C   . ASN C 1 136 ? -41.034 17.223  31.05   1    28.2   ? 132 ASN C C   1 
ATOM   5604 O  O   . ASN C 1 136 ? -41.061 16.151  30.452  1    27.95  ? 132 ASN C O   1 
ATOM   5605 C  CB  . ASN C 1 136 ? -41.448 16.155  33.31   1    26.53  ? 132 ASN C CB  1 
ATOM   5606 C  CG  . ASN C 1 136 ? -40.893 15.884  34.7    1    30.64  ? 132 ASN C CG  1 
ATOM   5607 O  OD1 . ASN C 1 136 ? -39.852 16.429  35.098  1    29.52  ? 132 ASN C OD1 1 
ATOM   5608 N  ND2 . ASN C 1 136 ? -41.583 15.066  35.482  1    29.37  ? 132 ASN C ND2 1 
ATOM   5609 N  N   . LEU C 1 137 ? -41.275 18.393  30.443  1    27.76  ? 133 LEU C N   1 
ATOM   5610 C  CA  . LEU C 1 137 ? -41.548 18.465  29.014  1    26.15  ? 133 LEU C CA  1 
ATOM   5611 C  C   . LEU C 1 137 ? -40.442 19.314  28.39   1    29.03  ? 133 LEU C C   1 
ATOM   5612 O  O   . LEU C 1 137 ? -40.141 20.389  28.906  1    27.15  ? 133 LEU C O   1 
ATOM   5613 C  CB  . LEU C 1 137 ? -42.935 19.058  28.777  1    26.3   ? 133 LEU C CB  1 
ATOM   5614 C  CG  . LEU C 1 137 ? -44.122 18.406  29.502  1    26.62  ? 133 LEU C CG  1 
ATOM   5615 C  CD1 . LEU C 1 137 ? -45.408 19.128  29.182  1    24.66  ? 133 LEU C CD1 1 
ATOM   5616 C  CD2 . LEU C 1 137 ? -44.281 16.954  29.121  1    24.45  ? 133 LEU C CD2 1 
ATOM   5617 N  N   . LEU C 1 138 ? -39.816 18.814  27.31   1    28.95  ? 134 LEU C N   1 
ATOM   5618 C  CA  . LEU C 1 138 ? -38.629 19.453  26.762  1    29.46  ? 134 LEU C CA  1 
ATOM   5619 C  C   . LEU C 1 138 ? -38.939 19.997  25.372  1    31.09  ? 134 LEU C C   1 
ATOM   5620 O  O   . LEU C 1 138 ? -39.62  19.351  24.571  1    38.52  ? 134 LEU C O   1 
ATOM   5621 C  CB  . LEU C 1 138 ? -37.48  18.446  26.729  1    31.32  ? 134 LEU C CB  1 
ATOM   5622 C  CG  . LEU C 1 138 ? -37.162 17.728  28.053  1    30.83  ? 134 LEU C CG  1 
ATOM   5623 C  CD1 . LEU C 1 138 ? -36.062 16.688  27.84   1    29.77  ? 134 LEU C CD1 1 
ATOM   5624 C  CD2 . LEU C 1 138 ? -36.854 18.591  29.272  1    22.52  ? 134 LEU C CD2 1 
ATOM   5625 N  N   . ILE C 1 139 ? -38.433 21.205  25.099  1    27.65  ? 135 ILE C N   1 
ATOM   5626 C  CA  . ILE C 1 139 ? -38.62  21.846  23.81   1    26.75  ? 135 ILE C CA  1 
ATOM   5627 C  C   . ILE C 1 139 ? -37.253 22.067  23.17   1    28.8   ? 135 ILE C C   1 
ATOM   5628 O  O   . ILE C 1 139 ? -36.268 22.284  23.868  1    28.84  ? 135 ILE C O   1 
ATOM   5629 C  CB  . ILE C 1 139 ? -39.338 23.191  24.008  1    25.5   ? 135 ILE C CB  1 
ATOM   5630 C  CG1 . ILE C 1 139 ? -38.537 24.14   24.871  1    26.81  ? 135 ILE C CG1 1 
ATOM   5631 C  CG2 . ILE C 1 139 ? -40.728 22.975  24.579  1    24.06  ? 135 ILE C CG2 1 
ATOM   5632 C  CD1 . ILE C 1 139 ? -39.016 25.571  24.783  1    25.85  ? 135 ILE C CD1 1 
ATOM   5633 N  N   . ASN C 1 140 ? -37.209 22.038  21.839  1    32.53  ? 136 ASN C N   1 
ATOM   5634 C  CA  . ASN C 1 140 ? -36.03  22.486  21.111  1    37.07  ? 136 ASN C CA  1 
ATOM   5635 C  C   . ASN C 1 140 ? -36.344 23.8    20.401  1    39.16  ? 136 ASN C C   1 
ATOM   5636 O  O   . ASN C 1 140 ? -37.459 24.318  20.544  1    46.92  ? 136 ASN C O   1 
ATOM   5637 C  CB  . ASN C 1 140 ? -35.484 21.422  20.171  1    35.93  ? 136 ASN C CB  1 
ATOM   5638 C  CG  . ASN C 1 140 ? -36.456 21.035  19.076  1    41.08  ? 136 ASN C CG  1 
ATOM   5639 O  OD1 . ASN C 1 140 ? -37.411 21.755  18.767  1    40.4   ? 136 ASN C OD1 1 
ATOM   5640 N  ND2 . ASN C 1 140 ? -36.224 19.889  18.459  1    45.18  ? 136 ASN C ND2 1 
ATOM   5641 N  N   . THR C 1 141 ? -35.365 24.276  19.621  1    41.32  ? 137 THR C N   1 
ATOM   5642 C  CA  . THR C 1 141 ? -35.425 25.565  18.94   1    44.51  ? 137 THR C CA  1 
ATOM   5643 C  C   . THR C 1 141 ? -36.171 25.465  17.607  1    46.83  ? 137 THR C C   1 
ATOM   5644 O  O   . THR C 1 141 ? -36.303 26.47   16.905  1    54.13  ? 137 THR C O   1 
ATOM   5645 C  CB  . THR C 1 141 ? -34.034 26.165  18.705  1    44.38  ? 137 THR C CB  1 
ATOM   5646 O  OG1 . THR C 1 141 ? -33.387 25.451  17.666  1    50.03  ? 137 THR C OG1 1 
ATOM   5647 C  CG2 . THR C 1 141 ? -33.096 26.074  19.887  1    42.87  ? 137 THR C CG2 1 
ATOM   5648 N  N   . GLU C 1 142 ? -36.647 24.264  17.247  1    45.67  ? 138 GLU C N   1 
ATOM   5649 C  CA  . GLU C 1 142 ? -37.283 24.066  15.956  1    45.51  ? 138 GLU C CA  1 
ATOM   5650 C  C   . GLU C 1 142 ? -38.769 23.734  16.082  1    44.43  ? 138 GLU C C   1 
ATOM   5651 O  O   . GLU C 1 142 ? -39.379 23.298  15.109  1    47.64  ? 138 GLU C O   1 
ATOM   5652 C  CB  . GLU C 1 142 ? -36.528 23.001  15.166  1    50.11  ? 138 GLU C CB  1 
ATOM   5653 C  CG  . GLU C 1 142 ? -35.025 23.254  15.111  1    59.51  ? 138 GLU C CG  1 
ATOM   5654 C  CD  . GLU C 1 142 ? -34.379 23.062  13.751  1    66.64  ? 138 GLU C CD  1 
ATOM   5655 O  OE1 . GLU C 1 142 ? -34.433 21.908  13.237  1    61.86  ? 138 GLU C OE1 1 
ATOM   5656 O  OE2 . GLU C 1 142 ? -33.848 24.085  13.22   1    63.6   ? 138 GLU C OE2 1 
ATOM   5657 N  N   . GLY C 1 143 ? -39.342 23.923  17.277  1    42.16  ? 139 GLY C N   1 
ATOM   5658 C  CA  . GLY C 1 143 ? -40.784 23.897  17.485  1    41.14  ? 139 GLY C CA  1 
ATOM   5659 C  C   . GLY C 1 143 ? -41.297 22.565  18.039  1    41.79  ? 139 GLY C C   1 
ATOM   5660 O  O   . GLY C 1 143 ? -42.513 22.365  18.147  1    39.45  ? 139 GLY C O   1 
ATOM   5661 N  N   . ALA C 1 144 ? -40.371 21.662  18.402  1    36.71  ? 140 ALA C N   1 
ATOM   5662 C  CA  . ALA C 1 144 ? -40.75  20.362  18.928  1    36.51  ? 140 ALA C CA  1 
ATOM   5663 C  C   . ALA C 1 144 ? -40.888 20.441  20.443  1    33.53  ? 140 ALA C C   1 
ATOM   5664 O  O   . ALA C 1 144 ? -40.196 21.246  21.077  1    33.94  ? 140 ALA C O   1 
ATOM   5665 C  CB  . ALA C 1 144 ? -39.717 19.336  18.523  1    38.02  ? 140 ALA C CB  1 
ATOM   5666 N  N   . ILE C 1 145 ? -41.779 19.594  20.991  1    31.9   ? 141 ILE C N   1 
ATOM   5667 C  CA  . ILE C 1 145 ? -41.836 19.309  22.424  1    34.79  ? 141 ILE C CA  1 
ATOM   5668 C  C   . ILE C 1 145 ? -41.885 17.795  22.646  1    35.64  ? 141 ILE C C   1 
ATOM   5669 O  O   . ILE C 1 145 ? -42.511 17.084  21.871  1    37.86  ? 141 ILE C O   1 
ATOM   5670 C  CB  . ILE C 1 145 ? -43.047 20.013  23.064  1    30.81  ? 141 ILE C CB  1 
ATOM   5671 C  CG1 . ILE C 1 145 ? -42.994 19.98   24.588  1    31.85  ? 141 ILE C CG1 1 
ATOM   5672 C  CG2 . ILE C 1 145 ? -44.357 19.453  22.522  1    27.23  ? 141 ILE C CG2 1 
ATOM   5673 C  CD1 . ILE C 1 145 ? -43.914 20.989  25.273  1    27.98  ? 141 ILE C CD1 1 
ATOM   5674 N  N   . LYS C 1 146 ? -41.259 17.306  23.721  1    35.59  ? 142 LYS C N   1 
ATOM   5675 C  CA  . LYS C 1 146 ? -41.237 15.873  24.012  1    33.54  ? 142 LYS C CA  1 
ATOM   5676 C  C   . LYS C 1 146 ? -41.481 15.591  25.496  1    30.06  ? 142 LYS C C   1 
ATOM   5677 O  O   . LYS C 1 146 ? -41.004 16.339  26.346  1    29.63  ? 142 LYS C O   1 
ATOM   5678 C  CB  . LYS C 1 146 ? -39.879 15.274  23.615  1    32.7   ? 142 LYS C CB  1 
ATOM   5679 C  CG  . LYS C 1 146 ? -39.439 15.657  22.222  1    31.71  ? 142 LYS C CG  1 
ATOM   5680 C  CD  . LYS C 1 146 ? -38.255 14.864  21.705  1    32.31  ? 142 LYS C CD  1 
ATOM   5681 C  CE  . LYS C 1 146 ? -37.783 15.399  20.361  1    31.47  ? 142 LYS C CE  1 
ATOM   5682 N  NZ  . LYS C 1 146 ? -36.93  14.433  19.663  1    29     ? 142 LYS C NZ  1 
ATOM   5683 N  N   . LEU C 1 147 ? -42.211 14.5    25.795  1    30.32  ? 143 LEU C N   1 
ATOM   5684 C  CA  . LEU C 1 147 ? -42.267 13.918  27.133  1    30.78  ? 143 LEU C CA  1 
ATOM   5685 C  C   . LEU C 1 147 ? -40.871 13.46   27.568  1    32.52  ? 143 LEU C C   1 
ATOM   5686 O  O   . LEU C 1 147 ? -40.155 12.784  26.824  1    35.62  ? 143 LEU C O   1 
ATOM   5687 C  CB  . LEU C 1 147 ? -43.193 12.703  27.181  1    28.86  ? 143 LEU C CB  1 
ATOM   5688 C  CG  . LEU C 1 147 ? -44.574 12.804  26.544  1    28.57  ? 143 LEU C CG  1 
ATOM   5689 C  CD1 . LEU C 1 147 ? -45.368 11.562  26.943  1    27.37  ? 143 LEU C CD1 1 
ATOM   5690 C  CD2 . LEU C 1 147 ? -45.257 14.046  26.992  1    28.13  ? 143 LEU C CD2 1 
ATOM   5691 N  N   . ALA C 1 148 ? -40.511 13.775  28.807  1    30.77  ? 144 ALA C N   1 
ATOM   5692 C  CA  . ALA C 1 148 ? -39.252 13.339  29.393  1    30.53  ? 144 ALA C CA  1 
ATOM   5693 C  C   . ALA C 1 148 ? -39.494 12.892  30.838  1    31.73  ? 144 ALA C C   1 
ATOM   5694 O  O   . ALA C 1 148 ? -40.628 12.838  31.302  1    33.46  ? 144 ALA C O   1 
ATOM   5695 C  CB  . ALA C 1 148 ? -38.257 14.465  29.349  1    27.27  ? 144 ALA C CB  1 
ATOM   5696 N  N   . ASP C 1 149 ? -38.416 12.539  31.527  1    34.11  ? 145 ASP C N   1 
ATOM   5697 C  CA  . ASP C 1 149 ? -38.426 12.027  32.886  1    36.49  ? 145 ASP C CA  1 
ATOM   5698 C  C   . ASP C 1 149 ? -39.44  10.905  33.104  1    34.21  ? 145 ASP C C   1 
ATOM   5699 O  O   . ASP C 1 149 ? -40.404 11.101  33.83   1    34.96  ? 145 ASP C O   1 
ATOM   5700 C  CB  . ASP C 1 149 ? -38.509 13.134  33.926  1    42.73  ? 145 ASP C CB  1 
ATOM   5701 C  CG  . ASP C 1 149 ? -38.081 12.684  35.323  1    59.52  ? 145 ASP C CG  1 
ATOM   5702 O  OD1 . ASP C 1 149 ? -37.928 11.436  35.528  1    50.71  ? 145 ASP C OD1 1 
ATOM   5703 O  OD2 . ASP C 1 149 ? -37.859 13.576  36.188  1    63.61  ? 145 ASP C OD2 1 
ATOM   5704 N  N   . PHE C 1 150 ? -39.181 9.715   32.552  1    32.57  ? 146 PHE C N   1 
ATOM   5705 C  CA  . PHE C 1 150 ? -40.042 8.56    32.792  1    33.54  ? 146 PHE C CA  1 
ATOM   5706 C  C   . PHE C 1 150 ? -39.676 7.814   34.084  1    35.1   ? 146 PHE C C   1 
ATOM   5707 O  O   . PHE C 1 150 ? -39.952 6.622   34.208  1    34.88  ? 146 PHE C O   1 
ATOM   5708 C  CB  . PHE C 1 150 ? -39.899 7.556   31.649  1    30.49  ? 146 PHE C CB  1 
ATOM   5709 C  CG  . PHE C 1 150 ? -40.663 8.052   30.447  1    30.38  ? 146 PHE C CG  1 
ATOM   5710 C  CD1 . PHE C 1 150 ? -40.242 9.201   29.786  1    27.91  ? 146 PHE C CD1 1 
ATOM   5711 C  CD2 . PHE C 1 150 ? -41.835 7.405   30.052  1    27.82  ? 146 PHE C CD2 1 
ATOM   5712 C  CE1 . PHE C 1 150 ? -40.992 9.684   28.722  1    30.66  ? 146 PHE C CE1 1 
ATOM   5713 C  CE2 . PHE C 1 150 ? -42.568 7.88    28.983  1    26.17  ? 146 PHE C CE2 1 
ATOM   5714 C  CZ  . PHE C 1 150 ? -42.139 9.016   28.314  1    29.61  ? 146 PHE C CZ  1 
ATOM   5715 N  N   . GLY C 1 151 ? -39.059 8.506   35.045  1    34.04  ? 147 GLY C N   1 
ATOM   5716 C  CA  . GLY C 1 151 ? -38.629 7.87    36.28   1    35.2   ? 147 GLY C CA  1 
ATOM   5717 C  C   . GLY C 1 151 ? -39.797 7.304   37.086  1    38.31  ? 147 GLY C C   1 
ATOM   5718 O  O   . GLY C 1 151 ? -39.637 6.298   37.752  1    41.96  ? 147 GLY C O   1 
ATOM   5719 N  N   . LEU C 1 152 ? -40.966 7.96    37.023  1    39.17  ? 148 LEU C N   1 
ATOM   5720 C  CA  . LEU C 1 152 ? -42.145 7.509   37.735  1    35.22  ? 148 LEU C CA  1 
ATOM   5721 C  C   . LEU C 1 152 ? -43.108 6.775   36.811  1    29.87  ? 148 LEU C C   1 
ATOM   5722 O  O   . LEU C 1 152 ? -44.252 6.579   37.2    1    33.93  ? 148 LEU C O   1 
ATOM   5723 C  CB  . LEU C 1 152 ? -42.802 8.703   38.421  1    38.46  ? 148 LEU C CB  1 
ATOM   5724 C  CG  . LEU C 1 152 ? -42.214 9.041   39.793  1    41.23  ? 148 LEU C CG  1 
ATOM   5725 C  CD1 . LEU C 1 152 ? -40.793 9.499   39.536  1    49.98  ? 148 LEU C CD1 1 
ATOM   5726 C  CD2 . LEU C 1 152 ? -43.027 10.132  40.472  1    42.52  ? 148 LEU C CD2 1 
ATOM   5727 N  N   . ALA C 1 153 ? -42.653 6.389   35.614  1    27.58  ? 149 ALA C N   1 
ATOM   5728 C  CA  . ALA C 1 153 ? -43.501 5.705   34.643  1    29.9   ? 149 ALA C CA  1 
ATOM   5729 C  C   . ALA C 1 153 ? -43.73  4.253   35.063  1    31.51  ? 149 ALA C C   1 
ATOM   5730 O  O   . ALA C 1 153 ? -43.08  3.768   35.975  1    31.18  ? 149 ALA C O   1 
ATOM   5731 C  CB  . ALA C 1 153 ? -42.911 5.797   33.259  1    27.55  ? 149 ALA C CB  1 
ATOM   5732 N  N   . ARG C 1 154 ? -44.666 3.57    34.394  1    33.79  ? 150 ARG C N   1 
ATOM   5733 C  CA  . ARG C 1 154 ? -45.071 2.217   34.769  1    34.21  ? 150 ARG C CA  1 
ATOM   5734 C  C   . ARG C 1 154 ? -45.789 1.509   33.611  1    32.89  ? 150 ARG C C   1 
ATOM   5735 O  O   . ARG C 1 154 ? -46.651 2.078   32.935  1    35.6   ? 150 ARG C O   1 
ATOM   5736 C  CB  . ARG C 1 154 ? -45.879 2.329   36.066  1    35.19  ? 150 ARG C CB  1 
ATOM   5737 C  CG  . ARG C 1 154 ? -47.003 1.315   36.208  1    39.3   ? 150 ARG C CG  1 
ATOM   5738 C  CD  . ARG C 1 154 ? -46.55  -0.024  36.731  1    38.85  ? 150 ARG C CD  1 
ATOM   5739 N  NE  . ARG C 1 154 ? -46.57  -0.08   38.194  1    38.5   ? 150 ARG C NE  1 
ATOM   5740 C  CZ  . ARG C 1 154 ? -46.495 -1.218  38.865  1    35.28  ? 150 ARG C CZ  1 
ATOM   5741 N  NH1 . ARG C 1 154 ? -46.505 -1.211  40.193  1    30.86  ? 150 ARG C NH1 1 
ATOM   5742 N  NH2 . ARG C 1 154 ? -46.415 -2.355  38.192  1    31.52  ? 150 ARG C NH2 1 
ATOM   5743 N  N   . ALA C 1 155 ? -45.409 0.256   33.358  1    32.56  ? 151 ALA C N   1 
ATOM   5744 C  CA  . ALA C 1 155 ? -46.075 -0.538  32.333  1    29.69  ? 151 ALA C CA  1 
ATOM   5745 C  C   . ALA C 1 155 ? -47.33  -1.128  32.964  1    31.81  ? 151 ALA C C   1 
ATOM   5746 O  O   . ALA C 1 155 ? -47.242 -1.824  33.962  1    35.55  ? 151 ALA C O   1 
ATOM   5747 C  CB  . ALA C 1 155 ? -45.153 -1.621  31.804  1    20.81  ? 151 ALA C CB  1 
ATOM   5748 N  N   . PHE C 1 156 ? -48.502 -0.822  32.416  1    32.2   ? 152 PHE C N   1 
ATOM   5749 C  CA  . PHE C 1 156 ? -49.718 -1.329  33.03   1    34.6   ? 152 PHE C CA  1 
ATOM   5750 C  C   . PHE C 1 156 ? -50.196 -2.574  32.296  1    37.26  ? 152 PHE C C   1 
ATOM   5751 O  O   . PHE C 1 156 ? -49.706 -2.888  31.211  1    36.73  ? 152 PHE C O   1 
ATOM   5752 C  CB  . PHE C 1 156 ? -50.856 -0.306  33.109  1    29.03  ? 152 PHE C CB  1 
ATOM   5753 C  CG  . PHE C 1 156 ? -51.303 0.333   31.809  1    29.22  ? 152 PHE C CG  1 
ATOM   5754 C  CD1 . PHE C 1 156 ? -50.583 1.39    31.242  1    31.81  ? 152 PHE C CD1 1 
ATOM   5755 C  CD2 . PHE C 1 156 ? -52.488 -0.071  31.193  1    25.27  ? 152 PHE C CD2 1 
ATOM   5756 C  CE1 . PHE C 1 156 ? -51.04  1.993   30.065  1    32.38  ? 152 PHE C CE1 1 
ATOM   5757 C  CE2 . PHE C 1 156 ? -52.926 0.536   30.018  1    24.4   ? 152 PHE C CE2 1 
ATOM   5758 C  CZ  . PHE C 1 156 ? -52.22  1.571   29.456  1    26.75  ? 152 PHE C CZ  1 
ATOM   5759 N  N   . GLY C 1 157 ? -51.152 -3.261  32.943  1    37.2   ? 153 GLY C N   1 
ATOM   5760 C  CA  . GLY C 1 157 ? -51.919 -4.346  32.356  1    41.3   ? 153 GLY C CA  1 
ATOM   5761 C  C   . GLY C 1 157 ? -53.373 -3.931  32.096  1    45.84  ? 153 GLY C C   1 
ATOM   5762 O  O   . GLY C 1 157 ? -53.831 -2.899  32.592  1    42.84  ? 153 GLY C O   1 
ATOM   5763 N  N   . VAL C 1 158 ? -54.084 -4.743  31.295  1    41.64  ? 154 VAL C N   1 
ATOM   5764 C  CA  . VAL C 1 158 ? -55.485 -4.532  30.969  1    38.39  ? 154 VAL C CA  1 
ATOM   5765 C  C   . VAL C 1 158 ? -56.276 -5.71   31.535  1    39.33  ? 154 VAL C C   1 
ATOM   5766 O  O   . VAL C 1 158 ? -56.042 -6.845  31.122  1    45.55  ? 154 VAL C O   1 
ATOM   5767 C  CB  . VAL C 1 158 ? -55.621 -4.443  29.436  1    40.89  ? 154 VAL C CB  1 
ATOM   5768 C  CG1 . VAL C 1 158 ? -57.077 -4.348  28.982  1    40.29  ? 154 VAL C CG1 1 
ATOM   5769 C  CG2 . VAL C 1 158 ? -54.77  -3.318  28.857  1    36.31  ? 154 VAL C CG2 1 
ATOM   5770 N  N   . PRO C 1 159 ? -57.187 -5.542  32.526  1    38.86  ? 155 PRO C N   1 
ATOM   5771 C  CA  . PRO C 1 159 ? -57.45  -4.255  33.145  1    37.16  ? 155 PRO C CA  1 
ATOM   5772 C  C   . PRO C 1 159 ? -56.368 -3.797  34.099  1    37.34  ? 155 PRO C C   1 
ATOM   5773 O  O   . PRO C 1 159 ? -55.446 -4.565  34.428  1    37.37  ? 155 PRO C O   1 
ATOM   5774 C  CB  . PRO C 1 159 ? -58.752 -4.536  33.884  1    34.18  ? 155 PRO C CB  1 
ATOM   5775 C  CG  . PRO C 1 159 ? -58.582 -5.942  34.368  1    35.37  ? 155 PRO C CG  1 
ATOM   5776 C  CD  . PRO C 1 159 ? -58.029 -6.594  33.123  1    34.64  ? 155 PRO C CD  1 
ATOM   5777 N  N   . VAL C 1 160 ? -56.492 -2.556  34.554  1    35.81  ? 156 VAL C N   1 
ATOM   5778 C  CA  . VAL C 1 160 ? -55.44  -1.985  35.433  1    33.95  ? 156 VAL C CA  1 
ATOM   5779 C  C   . VAL C 1 160 ? -55.516 -2.644  36.808  1    32.33  ? 156 VAL C C   1 
ATOM   5780 O  O   . VAL C 1 160 ? -56.596 -3.132  37.175  1    41.31  ? 156 VAL C O   1 
ATOM   5781 C  CB  . VAL C 1 160 ? -55.563 -0.456  35.53   1    32.22  ? 156 VAL C CB  1 
ATOM   5782 C  CG1 . VAL C 1 160 ? -55.574 0.2     34.157  1    32.53  ? 156 VAL C CG1 1 
ATOM   5783 C  CG2 . VAL C 1 160 ? -56.759 -0.018  36.363  1    32.77  ? 156 VAL C CG2 1 
ATOM   5784 N  N   . ARG C 1 161 ? -54.391 -2.687  37.508  1    34.93  ? 157 ARG C N   1 
ATOM   5785 C  CA  . ARG C 1 161 ? -54.366 -3.212  38.89   1    39.45  ? 157 ARG C CA  1 
ATOM   5786 C  C   . ARG C 1 161 ? -54.214 -2.009  39.819  1    38.54  ? 157 ARG C C   1 
ATOM   5787 O  O   . ARG C 1 161 ? -54.231 -0.871  39.318  1    37.1   ? 157 ARG C O   1 
ATOM   5788 C  CB  . ARG C 1 161 ? -53.157 -4.136  39.033  1    39.42  ? 157 ARG C CB  1 
ATOM   5789 C  CG  . ARG C 1 161 ? -53.347 -5.506  39.659  1    42.31  ? 157 ARG C CG  1 
ATOM   5790 C  CD  . ARG C 1 161 ? -52.014 -6.231  39.635  1    46.44  ? 157 ARG C CD  1 
ATOM   5791 N  NE  . ARG C 1 161 ? -50.916 -5.411  40.159  1    50.67  ? 157 ARG C NE  1 
ATOM   5792 C  CZ  . ARG C 1 161 ? -49.654 -5.517  39.77   1    43.7   ? 157 ARG C CZ  1 
ATOM   5793 N  NH1 . ARG C 1 161 ? -49.333 -6.356  38.805  1    39.87  ? 157 ARG C NH1 1 
ATOM   5794 N  NH2 . ARG C 1 161 ? -48.72  -4.787  40.347  1    40.4   ? 157 ARG C NH2 1 
ATOM   5795 N  N   . THR C 1 162 ? -54.063 -2.247  41.118  1    36.17  ? 158 THR C N   1 
ATOM   5796 C  CA  . THR C 1 162 ? -53.795 -1.126  42.032  1    36.1   ? 158 THR C CA  1 
ATOM   5797 C  C   . THR C 1 162 ? -52.322 -0.81   41.941  1    33.98  ? 158 THR C C   1 
ATOM   5798 O  O   . THR C 1 162 ? -51.51  -1.711  42.194  1    31.78  ? 158 THR C O   1 
ATOM   5799 C  CB  . THR C 1 162 ? -54.251 -1.462  43.448  1    36.25  ? 158 THR C CB  1 
ATOM   5800 O  OG1 . THR C 1 162 ? -55.667 -1.525  43.341  1    42     ? 158 THR C OG1 1 
ATOM   5801 C  CG2 . THR C 1 162 ? -53.858 -0.401  44.459  1    33.88  ? 158 THR C CG2 1 
ATOM   5802 N  N   . TYR C 1 163 ? -51.996 0.421   41.553  1    33.5   ? 159 TYR C N   1 
ATOM   5803 C  CA  . TYR C 1 163 ? -50.582 0.837   41.39   1    32.33  ? 159 TYR C CA  1 
ATOM   5804 C  C   . TYR C 1 163 ? -50.213 1.797   42.506  1    32.06  ? 159 TYR C C   1 
ATOM   5805 O  O   . TYR C 1 163 ? -51.064 2.052   43.372  1    37.87  ? 159 TYR C O   1 
ATOM   5806 C  CB  . TYR C 1 163 ? -50.402 1.407   39.981  1    35.79  ? 159 TYR C CB  1 
ATOM   5807 C  CG  . TYR C 1 163 ? -50.739 0.451   38.846  1    37.11  ? 159 TYR C CG  1 
ATOM   5808 C  CD1 . TYR C 1 163 ? -50.472 -0.907  38.947  1    39.03  ? 159 TYR C CD1 1 
ATOM   5809 C  CD2 . TYR C 1 163 ? -51.325 0.912   37.675  1    36.03  ? 159 TYR C CD2 1 
ATOM   5810 C  CE1 . TYR C 1 163 ? -50.786 -1.779  37.919  1    39.1   ? 159 TYR C CE1 1 
ATOM   5811 C  CE2 . TYR C 1 163 ? -51.649 0.049   36.643  1    35.01  ? 159 TYR C CE2 1 
ATOM   5812 C  CZ  . TYR C 1 163 ? -51.376 -1.299  36.765  1    36.55  ? 159 TYR C CZ  1 
ATOM   5813 O  OH  . TYR C 1 163 ? -51.69  -2.154  35.751  1    39.5   ? 159 TYR C OH  1 
HETATM 5814 N  N   . TPO C 1 164 ? -48.993 2.328   42.485  1    32.69  ? 160 TPO C N   1 
HETATM 5815 C  CA  . TPO C 1 164 ? -48.498 3.168   43.568  1    33.83  ? 160 TPO C CA  1 
HETATM 5816 C  CB  . TPO C 1 164 ? -47.063 3.637   43.308  1    33.25  ? 160 TPO C CB  1 
HETATM 5817 C  CG2 . TPO C 1 164 ? -46.507 4.457   44.449  1    28.29  ? 160 TPO C CG2 1 
HETATM 5818 O  OG1 . TPO C 1 164 ? -46.227 2.44    43.157  1    34     ? 160 TPO C OG1 1 
HETATM 5819 P  P   . TPO C 1 164 ? -45.624 2.054   41.705  1    32.02  ? 160 TPO C P   1 
HETATM 5820 O  O1P . TPO C 1 164 ? -46.819 1.655   40.836  1    35.08  ? 160 TPO C O1P 1 
HETATM 5821 O  O2P . TPO C 1 164 ? -44.646 0.926   41.974  1    28.64  ? 160 TPO C O2P 1 
HETATM 5822 O  O3P . TPO C 1 164 ? -44.96  3.291   41.177  1    30.81  ? 160 TPO C O3P 1 
HETATM 5823 C  C   . TPO C 1 164 ? -49.338 4.436   43.664  1    36.59  ? 160 TPO C C   1 
HETATM 5824 O  O   . TPO C 1 164 ? -49.653 5.044   42.648  1    34.9   ? 160 TPO C O   1 
ATOM   5825 N  N   . HIS C 1 165 ? -49.673 4.838   44.893  1    42.68  ? 161 HIS C N   1 
ATOM   5826 C  CA  . HIS C 1 165 ? -50.604 5.933   45.092  1    47.04  ? 161 HIS C CA  1 
ATOM   5827 C  C   . HIS C 1 165 ? -49.876 7.28    45.032  1    51.41  ? 161 HIS C C   1 
ATOM   5828 O  O   . HIS C 1 165 ? -50.39  8.255   44.472  1    44.94  ? 161 HIS C O   1 
ATOM   5829 C  CB  . HIS C 1 165 ? -51.362 5.722   46.4    1    51.35  ? 161 HIS C CB  1 
ATOM   5830 C  CG  . HIS C 1 165 ? -52.081 6.958   46.814  1    65.35  ? 161 HIS C CG  1 
ATOM   5831 N  ND1 . HIS C 1 165 ? -53.344 7.276   46.359  1    68.13  ? 161 HIS C ND1 1 
ATOM   5832 C  CD2 . HIS C 1 165 ? -51.689 7.981   47.607  1    58.66  ? 161 HIS C CD2 1 
ATOM   5833 C  CE1 . HIS C 1 165 ? -53.692 8.449   46.877  1    67.88  ? 161 HIS C CE1 1 
ATOM   5834 N  NE2 . HIS C 1 165 ? -52.707 8.886   47.636  1    61.85  ? 161 HIS C NE2 1 
ATOM   5835 N  N   . GLU C 1 166 ? -48.674 7.325   45.62   1    58.44  ? 162 GLU C N   1 
ATOM   5836 C  CA  . GLU C 1 166 ? -47.883 8.548   45.708  1    63.91  ? 162 GLU C CA  1 
ATOM   5837 C  C   . GLU C 1 166 ? -47.321 8.86    44.315  1    66.63  ? 162 GLU C C   1 
ATOM   5838 O  O   . GLU C 1 166 ? -46.148 8.587   44.051  1    77.06  ? 162 GLU C O   1 
ATOM   5839 C  CB  . GLU C 1 166 ? -46.776 8.44    46.77   1    56.14  ? 162 GLU C CB  1 
ATOM   5840 C  CG  . GLU C 1 166 ? -47.196 7.869   48.129  1    58.55  ? 162 GLU C CG  1 
ATOM   5841 C  CD  . GLU C 1 166 ? -47.6   6.397   48.274  1    68     ? 162 GLU C CD  1 
ATOM   5842 O  OE1 . GLU C 1 166 ? -48.729 6.124   48.73   1    71.79  ? 162 GLU C OE1 1 
ATOM   5843 O  OE2 . GLU C 1 166 ? -46.803 5.495   47.947  1    67.57  ? 162 GLU C OE2 1 
ATOM   5844 N  N   . VAL C 1 167 ? -48.165 9.404   43.416  1    52.78  ? 163 VAL C N   1 
ATOM   5845 C  CA  . VAL C 1 167 ? -47.768 9.689   42.038  1    48.33  ? 163 VAL C CA  1 
ATOM   5846 C  C   . VAL C 1 167 ? -48.344 11.035  41.589  1    47.47  ? 163 VAL C C   1 
ATOM   5847 O  O   . VAL C 1 167 ? -49.43  11.443  42.038  1    45.41  ? 163 VAL C O   1 
ATOM   5848 C  CB  . VAL C 1 167 ? -48.164 8.594   41.022  1    48.05  ? 163 VAL C CB  1 
ATOM   5849 C  CG1 . VAL C 1 167 ? -47.333 7.339   41.215  1    41.55  ? 163 VAL C CG1 1 
ATOM   5850 C  CG2 . VAL C 1 167 ? -49.667 8.3     41.053  1    42.5   ? 163 VAL C CG2 1 
ATOM   5851 N  N   . VAL C 1 168 ? -47.606 11.672  40.658  1    41.04  ? 164 VAL C N   1 
ATOM   5852 C  CA  . VAL C 1 168 ? -47.918 12.959  40.046  1    37.74  ? 164 VAL C CA  1 
ATOM   5853 C  C   . VAL C 1 168 ? -47.684 14.049  41.094  1    37.92  ? 164 VAL C C   1 
ATOM   5854 O  O   . VAL C 1 168 ? -48.143 13.947  42.237  1    33.87  ? 164 VAL C O   1 
ATOM   5855 C  CB  . VAL C 1 168 ? -49.343 13.059  39.448  1    38.58  ? 164 VAL C CB  1 
ATOM   5856 C  CG1 . VAL C 1 168 ? -49.512 14.32   38.627  1    34.53  ? 164 VAL C CG1 1 
ATOM   5857 C  CG2 . VAL C 1 168 ? -49.755 11.836  38.611  1    38.48  ? 164 VAL C CG2 1 
ATOM   5858 N  N   . THR C 1 169 ? -46.963 15.1    40.7    1    40.63  ? 165 THR C N   1 
ATOM   5859 C  CA  . THR C 1 169 ? -46.819 16.287  41.547  1    46.37  ? 165 THR C CA  1 
ATOM   5860 C  C   . THR C 1 169 ? -48.209 16.88   41.848  1    39.2   ? 165 THR C C   1 
ATOM   5861 O  O   . THR C 1 169 ? -49.072 16.938  40.967  1    38.77  ? 165 THR C O   1 
ATOM   5862 C  CB  . THR C 1 169 ? -45.876 17.289  40.863  1    44.16  ? 165 THR C CB  1 
ATOM   5863 O  OG1 . THR C 1 169 ? -44.714 16.587  40.418  1    44.82  ? 165 THR C OG1 1 
ATOM   5864 C  CG2 . THR C 1 169 ? -45.565 18.462  41.778  1    43.65  ? 165 THR C CG2 1 
ATOM   5865 N  N   . LEU C 1 170 ? -48.408 17.347  43.084  1    34.74  ? 166 LEU C N   1 
ATOM   5866 C  CA  . LEU C 1 170 ? -49.732 17.677  43.603  1    33.44  ? 166 LEU C CA  1 
ATOM   5867 C  C   . LEU C 1 170 ? -50.606 18.413  42.583  1    34.98  ? 166 LEU C C   1 
ATOM   5868 O  O   . LEU C 1 170 ? -51.724 17.99   42.262  1    40.07  ? 166 LEU C O   1 
ATOM   5869 C  CB  . LEU C 1 170 ? -49.571 18.521  44.865  1    29.54  ? 166 LEU C CB  1 
ATOM   5870 C  CG  . LEU C 1 170 ? -50.876 18.863  45.604  1    30.54  ? 166 LEU C CG  1 
ATOM   5871 C  CD1 . LEU C 1 170 ? -51.757 17.634  45.886  1    25.61  ? 166 LEU C CD1 1 
ATOM   5872 C  CD2 . LEU C 1 170 ? -50.563 19.599  46.914  1    25.13  ? 166 LEU C CD2 1 
ATOM   5873 N  N   . TRP C 1 171 ? -50.092 19.544  42.102  1    32.67  ? 167 TRP C N   1 
ATOM   5874 C  CA  . TRP C 1 171 ? -50.799 20.447  41.214  1    34.92  ? 167 TRP C CA  1 
ATOM   5875 C  C   . TRP C 1 171 ? -51.393 19.75   39.983  1    33.95  ? 167 TRP C C   1 
ATOM   5876 O  O   . TRP C 1 171 ? -52.345 20.251  39.392  1    35.86  ? 167 TRP C O   1 
ATOM   5877 C  CB  . TRP C 1 171 ? -49.821 21.543  40.773  1    33.81  ? 167 TRP C CB  1 
ATOM   5878 C  CG  . TRP C 1 171 ? -49.394 22.465  41.875  1    35.15  ? 167 TRP C CG  1 
ATOM   5879 C  CD1 . TRP C 1 171 ? -49.79  22.479  43.18   1    34.24  ? 167 TRP C CD1 1 
ATOM   5880 C  CD2 . TRP C 1 171 ? -48.504 23.587  41.722  1    35.99  ? 167 TRP C CD2 1 
ATOM   5881 N  NE1 . TRP C 1 171 ? -49.203 23.525  43.855  1    28.23  ? 167 TRP C NE1 1 
ATOM   5882 C  CE2 . TRP C 1 171 ? -48.427 24.229  42.981  1    31.83  ? 167 TRP C CE2 1 
ATOM   5883 C  CE3 . TRP C 1 171 ? -47.794 24.119  40.641  1    35.46  ? 167 TRP C CE3 1 
ATOM   5884 C  CZ2 . TRP C 1 171 ? -47.647 25.362  43.178  1    34.15  ? 167 TRP C CZ2 1 
ATOM   5885 C  CZ3 . TRP C 1 171 ? -47.046 25.259  40.845  1    39.79  ? 167 TRP C CZ3 1 
ATOM   5886 C  CH2 . TRP C 1 171 ? -46.965 25.863  42.094  1    32.16  ? 167 TRP C CH2 1 
ATOM   5887 N  N   . TYR C 1 172 ? -50.798 18.628  39.568  1    32.22  ? 168 TYR C N   1 
ATOM   5888 C  CA  . TYR C 1 172 ? -51.092 18.003  38.287  1    31.42  ? 168 TYR C CA  1 
ATOM   5889 C  C   . TYR C 1 172 ? -51.828 16.687  38.519  1    32.02  ? 168 TYR C C   1 
ATOM   5890 O  O   . TYR C 1 172 ? -52.131 15.959  37.566  1    30.53  ? 168 TYR C O   1 
ATOM   5891 C  CB  . TYR C 1 172 ? -49.773 17.869  37.507  1    30.67  ? 168 TYR C CB  1 
ATOM   5892 C  CG  . TYR C 1 172 ? -49.145 19.229  37.231  1    27.88  ? 168 TYR C CG  1 
ATOM   5893 C  CD1 . TYR C 1 172 ? -49.624 20.042  36.201  1    25.22  ? 168 TYR C CD1 1 
ATOM   5894 C  CD2 . TYR C 1 172 ? -48.14  19.726  38.054  1    26.57  ? 168 TYR C CD2 1 
ATOM   5895 C  CE1 . TYR C 1 172 ? -49.1   21.296  35.964  1    25.18  ? 168 TYR C CE1 1 
ATOM   5896 C  CE2 . TYR C 1 172 ? -47.626 20.993  37.845  1    27.96  ? 168 TYR C CE2 1 
ATOM   5897 C  CZ  . TYR C 1 172 ? -48.097 21.772  36.794  1    29.89  ? 168 TYR C CZ  1 
ATOM   5898 O  OH  . TYR C 1 172 ? -47.571 23.022  36.611  1    33.01  ? 168 TYR C OH  1 
ATOM   5899 N  N   . ARG C 1 173 ? -52.162 16.442  39.796  1    32.85  ? 169 ARG C N   1 
ATOM   5900 C  CA  . ARG C 1 173 ? -52.76  15.199  40.265  1    33.45  ? 169 ARG C CA  1 
ATOM   5901 C  C   . ARG C 1 173 ? -54.27  15.232  40.058  1    34.06  ? 169 ARG C C   1 
ATOM   5902 O  O   . ARG C 1 173 ? -54.97  16.148  40.532  1    32.53  ? 169 ARG C O   1 
ATOM   5903 C  CB  . ARG C 1 173 ? -52.436 14.989  41.75   1    34.51  ? 169 ARG C CB  1 
ATOM   5904 C  CG  . ARG C 1 173 ? -52.727 13.596  42.285  1    32.11  ? 169 ARG C CG  1 
ATOM   5905 C  CD  . ARG C 1 173 ? -52.247 13.447  43.71   1    33.78  ? 169 ARG C CD  1 
ATOM   5906 N  NE  . ARG C 1 173 ? -50.799 13.638  43.861  1    37.45  ? 169 ARG C NE  1 
ATOM   5907 C  CZ  . ARG C 1 173 ? -50.199 13.989  45.003  1    37.41  ? 169 ARG C CZ  1 
ATOM   5908 N  NH1 . ARG C 1 173 ? -50.909 14.18   46.111  1    36.68  ? 169 ARG C NH1 1 
ATOM   5909 N  NH2 . ARG C 1 173 ? -48.887 14.137  45.042  1    32.32  ? 169 ARG C NH2 1 
ATOM   5910 N  N   . ALA C 1 174 ? -54.752 14.189  39.378  1    33.8   ? 170 ALA C N   1 
ATOM   5911 C  CA  . ALA C 1 174 ? -56.158 14.07   39.029  1    34     ? 170 ALA C CA  1 
ATOM   5912 C  C   . ALA C 1 174 ? -56.983 13.82   40.292  1    35.17  ? 170 ALA C C   1 
ATOM   5913 O  O   . ALA C 1 174 ? -56.462 13.401  41.325  1    40.62  ? 170 ALA C O   1 
ATOM   5914 C  CB  . ALA C 1 174 ? -56.335 12.977  38      1    29.95  ? 170 ALA C CB  1 
ATOM   5915 N  N   . PRO C 1 175 ? -58.289 14.136  40.273  1    32.58  ? 171 PRO C N   1 
ATOM   5916 C  CA  . PRO C 1 175 ? -59.136 13.916  41.444  1    35.32  ? 171 PRO C CA  1 
ATOM   5917 C  C   . PRO C 1 175 ? -59.331 12.477  41.921  1    39.4   ? 171 PRO C C   1 
ATOM   5918 O  O   . PRO C 1 175 ? -59.642 12.253  43.087  1    38.37  ? 171 PRO C O   1 
ATOM   5919 C  CB  . PRO C 1 175 ? -60.449 14.621  41.064  1    33.55  ? 171 PRO C CB  1 
ATOM   5920 C  CG  . PRO C 1 175 ? -60.418 14.677  39.563  1    33.25  ? 171 PRO C CG  1 
ATOM   5921 C  CD  . PRO C 1 175 ? -58.973 14.816  39.171  1    32.36  ? 171 PRO C CD  1 
ATOM   5922 N  N   . GLU C 1 176 ? -59.15  11.507  41.016  1    39.12  ? 172 GLU C N   1 
ATOM   5923 C  CA  . GLU C 1 176 ? -59.333 10.106  41.367  1    36.16  ? 172 GLU C CA  1 
ATOM   5924 C  C   . GLU C 1 176 ? -58.196 9.612   42.263  1    39.92  ? 172 GLU C C   1 
ATOM   5925 O  O   . GLU C 1 176 ? -58.41  8.729   43.087  1    42.28  ? 172 GLU C O   1 
ATOM   5926 C  CB  . GLU C 1 176 ? -59.543 9.248   40.122  1    37.49  ? 172 GLU C CB  1 
ATOM   5927 C  CG  . GLU C 1 176 ? -58.43  9.375   39.092  1    38.61  ? 172 GLU C CG  1 
ATOM   5928 C  CD  . GLU C 1 176 ? -58.73  10.256  37.894  1    39.04  ? 172 GLU C CD  1 
ATOM   5929 O  OE1 . GLU C 1 176 ? -58.365 9.826   36.772  1    36.92  ? 172 GLU C OE1 1 
ATOM   5930 O  OE2 . GLU C 1 176 ? -59.332 11.352  38.076  1    39.17  ? 172 GLU C OE2 1 
ATOM   5931 N  N   . ILE C 1 177 ? -56.993 10.191  42.12   1    43.14  ? 173 ILE C N   1 
ATOM   5932 C  CA  . ILE C 1 177 ? -55.864 9.835   42.973  1    41.64  ? 173 ILE C CA  1 
ATOM   5933 C  C   . ILE C 1 177 ? -55.976 10.554  44.319  1    44.1   ? 173 ILE C C   1 
ATOM   5934 O  O   . ILE C 1 177 ? -55.609 9.99    45.342  1    40.6   ? 173 ILE C O   1 
ATOM   5935 C  CB  . ILE C 1 177 ? -54.515 10.143  42.296  1    40.61  ? 173 ILE C CB  1 
ATOM   5936 C  CG1 . ILE C 1 177 ? -54.447 9.595   40.888  1    41.93  ? 173 ILE C CG1 1 
ATOM   5937 C  CG2 . ILE C 1 177 ? -53.326 9.667   43.143  1    40.76  ? 173 ILE C CG2 1 
ATOM   5938 C  CD1 . ILE C 1 177 ? -53.33  10.206  40.061  1    41.17  ? 173 ILE C CD1 1 
ATOM   5939 N  N   . LEU C 1 178 ? -56.404 11.825  44.301  1    48.06  ? 174 LEU C N   1 
ATOM   5940 C  CA  . LEU C 1 178 ? -56.609 12.625  45.504  1    44.58  ? 174 LEU C CA  1 
ATOM   5941 C  C   . LEU C 1 178 ? -57.608 11.942  46.442  1    42.06  ? 174 LEU C C   1 
ATOM   5942 O  O   . LEU C 1 178 ? -57.292 11.736  47.613  1    41.08  ? 174 LEU C O   1 
ATOM   5943 C  CB  . LEU C 1 178 ? -57.093 14.023  45.118  1    41.08  ? 174 LEU C CB  1 
ATOM   5944 C  CG  . LEU C 1 178 ? -56.053 14.961  44.502  1    40.18  ? 174 LEU C CG  1 
ATOM   5945 C  CD1 . LEU C 1 178 ? -56.767 16.142  43.869  1    41.93  ? 174 LEU C CD1 1 
ATOM   5946 C  CD2 . LEU C 1 178 ? -55.022 15.423  45.534  1    37.4   ? 174 LEU C CD2 1 
ATOM   5947 N  N   . LEU C 1 179 ? -58.785 11.583  45.906  1    39.77  ? 175 LEU C N   1 
ATOM   5948 C  CA  . LEU C 1 179 ? -59.838 10.895  46.639  1    36.95  ? 175 LEU C CA  1 
ATOM   5949 C  C   . LEU C 1 179 ? -59.509 9.412   46.878  1    37.73  ? 175 LEU C C   1 
ATOM   5950 O  O   . LEU C 1 179 ? -60.406 8.647   47.171  1    38.51  ? 175 LEU C O   1 
ATOM   5951 C  CB  . LEU C 1 179 ? -61.144 11.064  45.859  1    33.88  ? 175 LEU C CB  1 
ATOM   5952 C  CG  . LEU C 1 179 ? -61.647 12.497  45.671  1    39.06  ? 175 LEU C CG  1 
ATOM   5953 C  CD1 . LEU C 1 179 ? -62.693 12.56   44.571  1    39.3   ? 175 LEU C CD1 1 
ATOM   5954 C  CD2 . LEU C 1 179 ? -62.225 13.097  46.948  1    42.18  ? 175 LEU C CD2 1 
ATOM   5955 N  N   . GLY C 1 180 ? -58.244 8.991   46.735  1    39.78  ? 176 GLY C N   1 
ATOM   5956 C  CA  . GLY C 1 180 ? -57.728 7.672   47.099  1    38.53  ? 176 GLY C CA  1 
ATOM   5957 C  C   . GLY C 1 180 ? -58.356 6.456   46.401  1    38.77  ? 176 GLY C C   1 
ATOM   5958 O  O   . GLY C 1 180 ? -58.323 5.365   46.971  1    37.41  ? 176 GLY C O   1 
ATOM   5959 N  N   . CYS C 1 181 ? -58.884 6.612   45.172  1    39.38  ? 177 CYS C N   1 
ATOM   5960 C  CA  . CYS C 1 181 ? -59.594 5.525   44.505  1    41.67  ? 177 CYS C CA  1 
ATOM   5961 C  C   . CYS C 1 181 ? -58.651 4.352   44.263  1    41.1   ? 177 CYS C C   1 
ATOM   5962 O  O   . CYS C 1 181 ? -57.51  4.576   43.898  1    42.54  ? 177 CYS C O   1 
ATOM   5963 C  CB  . CYS C 1 181 ? -60.108 5.926   43.128  1    46.67  ? 177 CYS C CB  1 
ATOM   5964 S  SG  . CYS C 1 181 ? -61.298 7.293   43.144  1    54.91  ? 177 CYS C SG  1 
ATOM   5965 N  N   . LYS C 1 182 ? -59.165 3.13    44.42   1    42.8   ? 178 LYS C N   1 
ATOM   5966 C  CA  . LYS C 1 182 ? -58.372 1.912   44.292  1    42.46  ? 178 LYS C CA  1 
ATOM   5967 C  C   . LYS C 1 182 ? -57.647 1.845   42.943  1    41.01  ? 178 LYS C C   1 
ATOM   5968 O  O   . LYS C 1 182 ? -56.504 1.392   42.872  1    41.49  ? 178 LYS C O   1 
ATOM   5969 C  CB  . LYS C 1 182 ? -59.237 0.668   44.539  1    39.32  ? 178 LYS C CB  1 
ATOM   5970 C  CG  . LYS C 1 182 ? -58.465 -0.593  44.922  1    37.76  ? 178 LYS C CG  1 
ATOM   5971 C  CD  . LYS C 1 182 ? -59.382 -1.758  45.272  1    34.46  ? 178 LYS C CD  1 
ATOM   5972 C  CE  . LYS C 1 182 ? -58.735 -3.095  45.02   1    38.59  ? 178 LYS C CE  1 
ATOM   5973 N  NZ  . LYS C 1 182 ? -59.669 -4.236  45.108  1    33.84  ? 178 LYS C NZ  1 
ATOM   5974 N  N   . TYR C 1 183 ? -58.337 2.233   41.869  1    39.25  ? 179 TYR C N   1 
ATOM   5975 C  CA  . TYR C 1 183 ? -57.783 2.041   40.543  1    40.5   ? 179 TYR C CA  1 
ATOM   5976 C  C   . TYR C 1 183 ? -57.673 3.382   39.836  1    43.19  ? 179 TYR C C   1 
ATOM   5977 O  O   . TYR C 1 183 ? -58.538 4.236   40.007  1    47.47  ? 179 TYR C O   1 
ATOM   5978 C  CB  . TYR C 1 183 ? -58.668 1.128   39.693  1    39.51  ? 179 TYR C CB  1 
ATOM   5979 C  CG  . TYR C 1 183 ? -58.847 -0.279  40.235  1    48.02  ? 179 TYR C CG  1 
ATOM   5980 C  CD1 . TYR C 1 183 ? -57.76  -1.043  40.646  1    53.71  ? 179 TYR C CD1 1 
ATOM   5981 C  CD2 . TYR C 1 183 ? -60.111 -0.844  40.342  1    46.93  ? 179 TYR C CD2 1 
ATOM   5982 C  CE1 . TYR C 1 183 ? -57.928 -2.33   41.142  1    50.9   ? 179 TYR C CE1 1 
ATOM   5983 C  CE2 . TYR C 1 183 ? -60.286 -2.124  40.84   1    48.71  ? 179 TYR C CE2 1 
ATOM   5984 C  CZ  . TYR C 1 183 ? -59.193 -2.872  41.239  1    52.05  ? 179 TYR C CZ  1 
ATOM   5985 O  OH  . TYR C 1 183 ? -59.343 -4.141  41.722  1    60.41  ? 179 TYR C OH  1 
ATOM   5986 N  N   . TYR C 1 184 ? -56.615 3.525   39.017  1    40.53  ? 180 TYR C N   1 
ATOM   5987 C  CA  . TYR C 1 184 ? -56.456 4.635   38.086  1    37.73  ? 180 TYR C CA  1 
ATOM   5988 C  C   . TYR C 1 184 ? -55.763 4.151   36.81   1    34.41  ? 180 TYR C C   1 
ATOM   5989 O  O   . TYR C 1 184 ? -55.165 3.08    36.795  1    35.33  ? 180 TYR C O   1 
ATOM   5990 C  CB  . TYR C 1 184 ? -55.733 5.816   38.734  1    34.53  ? 180 TYR C CB  1 
ATOM   5991 C  CG  . TYR C 1 184 ? -54.275 5.553   39.051  1    34.69  ? 180 TYR C CG  1 
ATOM   5992 C  CD1 . TYR C 1 184 ? -53.308 5.572   38.052  1    31.6   ? 180 TYR C CD1 1 
ATOM   5993 C  CD2 . TYR C 1 184 ? -53.873 5.312   40.36   1    35.87  ? 180 TYR C CD2 1 
ATOM   5994 C  CE1 . TYR C 1 184 ? -51.983 5.325   38.358  1    36.24  ? 180 TYR C CE1 1 
ATOM   5995 C  CE2 . TYR C 1 184 ? -52.547 5.062   40.673  1    33.86  ? 180 TYR C CE2 1 
ATOM   5996 C  CZ  . TYR C 1 184 ? -51.596 5.056   39.667  1    36.86  ? 180 TYR C CZ  1 
ATOM   5997 O  OH  . TYR C 1 184 ? -50.269 4.829   39.981  1    39.23  ? 180 TYR C OH  1 
ATOM   5998 N  N   . SER C 1 185 ? -55.841 4.969   35.753  1    32.75  ? 181 SER C N   1 
ATOM   5999 C  CA  . SER C 1 185 ? -55.548 4.536   34.397  1    34.85  ? 181 SER C CA  1 
ATOM   6000 C  C   . SER C 1 185 ? -55.047 5.705   33.548  1    32.96  ? 181 SER C C   1 
ATOM   6001 O  O   . SER C 1 185 ? -54.591 6.714   34.092  1    34.26  ? 181 SER C O   1 
ATOM   6002 C  CB  . SER C 1 185 ? -56.77  3.87    33.787  1    36.65  ? 181 SER C CB  1 
ATOM   6003 O  OG  . SER C 1 185 ? -56.502 3.372   32.479  1    34.95  ? 181 SER C OG  1 
ATOM   6004 N  N   . THR C 1 186 ? -55.126 5.562   32.215  1    30.6   ? 182 THR C N   1 
ATOM   6005 C  CA  . THR C 1 186 ? -54.515 6.512   31.294  1    33.17  ? 182 THR C CA  1 
ATOM   6006 C  C   . THR C 1 186 ? -55.096 7.898   31.538  1    36.53  ? 182 THR C C   1 
ATOM   6007 O  O   . THR C 1 186 ? -54.449 8.903   31.257  1    39.8   ? 182 THR C O   1 
ATOM   6008 C  CB  . THR C 1 186 ? -54.714 6.095   29.837  1    32.77  ? 182 THR C CB  1 
ATOM   6009 O  OG1 . THR C 1 186 ? -56.117 5.943   29.661  1    38.65  ? 182 THR C OG1 1 
ATOM   6010 C  CG2 . THR C 1 186 ? -53.977 4.82    29.483  1    27.24  ? 182 THR C CG2 1 
ATOM   6011 N  N   . ALA C 1 187 ? -56.319 7.935   32.072  1    36.84  ? 183 ALA C N   1 
ATOM   6012 C  CA  . ALA C 1 187 ? -57.016 9.183   32.344  1    39.17  ? 183 ALA C CA  1 
ATOM   6013 C  C   . ALA C 1 187 ? -56.152 10.184  33.128  1    41.38  ? 183 ALA C C   1 
ATOM   6014 O  O   . ALA C 1 187 ? -56.27  11.386  32.919  1    43.58  ? 183 ALA C O   1 
ATOM   6015 C  CB  . ALA C 1 187 ? -58.322 8.884   33.036  1    34.48  ? 183 ALA C CB  1 
ATOM   6016 N  N   . VAL C 1 188 ? -55.29  9.709   34.036  1    41.32  ? 184 VAL C N   1 
ATOM   6017 C  CA  . VAL C 1 188 ? -54.582 10.61   34.928  1    34.99  ? 184 VAL C CA  1 
ATOM   6018 C  C   . VAL C 1 188 ? -53.566 11.419  34.121  1    35.8   ? 184 VAL C C   1 
ATOM   6019 O  O   . VAL C 1 188 ? -53.283 12.574  34.432  1    40.63  ? 184 VAL C O   1 
ATOM   6020 C  CB  . VAL C 1 188 ? -53.941 9.9     36.137  1    32.84  ? 184 VAL C CB  1 
ATOM   6021 C  CG1 . VAL C 1 188 ? -54.932 8.967   36.817  1    29.24  ? 184 VAL C CG1 1 
ATOM   6022 C  CG2 . VAL C 1 188 ? -52.655 9.161   35.772  1    30.81  ? 184 VAL C CG2 1 
ATOM   6023 N  N   . ASP C 1 189 ? -53.024 10.819  33.066  1    32.82  ? 185 ASP C N   1 
ATOM   6024 C  CA  . ASP C 1 189 ? -52.075 11.532  32.234  1    34.51  ? 185 ASP C CA  1 
ATOM   6025 C  C   . ASP C 1 189 ? -52.81  12.643  31.498  1    33.41  ? 185 ASP C C   1 
ATOM   6026 O  O   . ASP C 1 189 ? -52.248 13.713  31.261  1    38.44  ? 185 ASP C O   1 
ATOM   6027 C  CB  . ASP C 1 189 ? -51.279 10.579  31.354  1    36.21  ? 185 ASP C CB  1 
ATOM   6028 C  CG  . ASP C 1 189 ? -50.255 9.713   32.091  1    41.25  ? 185 ASP C CG  1 
ATOM   6029 O  OD1 . ASP C 1 189 ? -49.762 10.129  33.184  1    36.99  ? 185 ASP C OD1 1 
ATOM   6030 O  OD2 . ASP C 1 189 ? -49.956 8.611   31.576  1    38.67  ? 185 ASP C OD2 1 
ATOM   6031 N  N   . ILE C 1 190 ? -54.083 12.403  31.178  1    30.15  ? 186 ILE C N   1 
ATOM   6032 C  CA  . ILE C 1 190 ? -54.854 13.384  30.429  1    30.8   ? 186 ILE C CA  1 
ATOM   6033 C  C   . ILE C 1 190 ? -55.155 14.593  31.314  1    29.79  ? 186 ILE C C   1 
ATOM   6034 O  O   . ILE C 1 190 ? -55.192 15.732  30.845  1    29.82  ? 186 ILE C O   1 
ATOM   6035 C  CB  . ILE C 1 190 ? -56.139 12.762  29.846  1    34.28  ? 186 ILE C CB  1 
ATOM   6036 C  CG1 . ILE C 1 190 ? -55.842 11.848  28.637  1    31.5   ? 186 ILE C CG1 1 
ATOM   6037 C  CG2 . ILE C 1 190 ? -57.17  13.845  29.504  1    32.52  ? 186 ILE C CG2 1 
ATOM   6038 C  CD1 . ILE C 1 190 ? -55.267 12.558  27.419  1    29.6   ? 186 ILE C CD1 1 
ATOM   6039 N  N   . TRP C 1 191 ? -55.408 14.336  32.598  1    27.8   ? 187 TRP C N   1 
ATOM   6040 C  CA  . TRP C 1 191 ? -55.717 15.418  33.505  1    27.66  ? 187 TRP C CA  1 
ATOM   6041 C  C   . TRP C 1 191 ? -54.524 16.372  33.548  1    29.96  ? 187 TRP C C   1 
ATOM   6042 O  O   . TRP C 1 191 ? -54.634 17.582  33.349  1    29.05  ? 187 TRP C O   1 
ATOM   6043 C  CB  . TRP C 1 191 ? -56.036 14.831  34.88   1    27.7   ? 187 TRP C CB  1 
ATOM   6044 C  CG  . TRP C 1 191 ? -56.342 15.883  35.913  1    31.6   ? 187 TRP C CG  1 
ATOM   6045 C  CD1 . TRP C 1 191 ? -55.438 16.465  36.746  1    28.82  ? 187 TRP C CD1 1 
ATOM   6046 C  CD2 . TRP C 1 191 ? -57.627 16.463  36.224  1    30.25  ? 187 TRP C CD2 1 
ATOM   6047 N  NE1 . TRP C 1 191 ? -56.068 17.366  37.552  1    30.77  ? 187 TRP C NE1 1 
ATOM   6048 C  CE2 . TRP C 1 191 ? -57.407 17.386  37.26   1    31.35  ? 187 TRP C CE2 1 
ATOM   6049 C  CE3 . TRP C 1 191 ? -58.936 16.275  35.761  1    31.9   ? 187 TRP C CE3 1 
ATOM   6050 C  CZ2 . TRP C 1 191 ? -58.447 18.13   37.819  1    32.78  ? 187 TRP C CZ2 1 
ATOM   6051 C  CZ3 . TRP C 1 191 ? -59.965 16.995  36.323  1    29.3   ? 187 TRP C CZ3 1 
ATOM   6052 C  CH2 . TRP C 1 191 ? -59.718 17.924  37.332  1    31.63  ? 187 TRP C CH2 1 
ATOM   6053 N  N   . SER C 1 192 ? -53.355 15.782  33.773  1    32.22  ? 188 SER C N   1 
ATOM   6054 C  CA  . SER C 1 192 ? -52.106 16.524  33.811  1    32.41  ? 188 SER C CA  1 
ATOM   6055 C  C   . SER C 1 192 ? -51.968 17.407  32.564  1    31.31  ? 188 SER C C   1 
ATOM   6056 O  O   . SER C 1 192 ? -51.799 18.62   32.682  1    30.77  ? 188 SER C O   1 
ATOM   6057 C  CB  . SER C 1 192 ? -50.941 15.565  34.02   1    29.36  ? 188 SER C CB  1 
ATOM   6058 O  OG  . SER C 1 192 ? -51.107 14.877  35.25   1    26.38  ? 188 SER C OG  1 
ATOM   6059 N  N   . LEU C 1 193 ? -52.114 16.803  31.377  1    27.97  ? 189 LEU C N   1 
ATOM   6060 C  CA  . LEU C 1 193 ? -52.017 17.554  30.14   1    29.48  ? 189 LEU C CA  1 
ATOM   6061 C  C   . LEU C 1 193 ? -53.02  18.696  30.129  1    31.97  ? 189 LEU C C   1 
ATOM   6062 O  O   . LEU C 1 193 ? -52.746 19.729  29.524  1    36.44  ? 189 LEU C O   1 
ATOM   6063 C  CB  . LEU C 1 193 ? -52.22  16.674  28.915  1    27.3   ? 189 LEU C CB  1 
ATOM   6064 C  CG  . LEU C 1 193 ? -51.036 15.797  28.518  1    30.91  ? 189 LEU C CG  1 
ATOM   6065 C  CD1 . LEU C 1 193 ? -51.242 15.294  27.106  1    31.56  ? 189 LEU C CD1 1 
ATOM   6066 C  CD2 . LEU C 1 193 ? -49.74  16.577  28.599  1    31.42  ? 189 LEU C CD2 1 
ATOM   6067 N  N   . GLY C 1 194 ? -54.189 18.479  30.745  1    31.37  ? 190 GLY C N   1 
ATOM   6068 C  CA  . GLY C 1 194 ? -55.238 19.478  30.775  1    27.47  ? 190 GLY C CA  1 
ATOM   6069 C  C   . GLY C 1 194 ? -54.797 20.682  31.591  1    29.15  ? 190 GLY C C   1 
ATOM   6070 O  O   . GLY C 1 194 ? -54.824 21.813  31.105  1    31.78  ? 190 GLY C O   1 
ATOM   6071 N  N   . CYS C 1 195 ? -54.35  20.415  32.818  1    32.83  ? 191 CYS C N   1 
ATOM   6072 C  CA  . CYS C 1 195 ? -53.688 21.406  33.662  1    31.83  ? 191 CYS C CA  1 
ATOM   6073 C  C   . CYS C 1 195 ? -52.546 22.117  32.93   1    30.98  ? 191 CYS C C   1 
ATOM   6074 O  O   . CYS C 1 195 ? -52.37  23.325  33.091  1    35.3   ? 191 CYS C O   1 
ATOM   6075 C  CB  . CYS C 1 195 ? -53.164 20.765  34.942  1    30.82  ? 191 CYS C CB  1 
ATOM   6076 S  SG  . CYS C 1 195 ? -54.47  19.943  35.897  1    33.67  ? 191 CYS C SG  1 
ATOM   6077 N  N   . ILE C 1 196 ? -51.787 21.385  32.112  1    28.94  ? 192 ILE C N   1 
ATOM   6078 C  CA  . ILE C 1 196 ? -50.694 21.974  31.349  1    30.64  ? 192 ILE C CA  1 
ATOM   6079 C  C   . ILE C 1 196 ? -51.22  22.82   30.193  1    29.46  ? 192 ILE C C   1 
ATOM   6080 O  O   . ILE C 1 196 ? -50.65  23.873  29.913  1    35.24  ? 192 ILE C O   1 
ATOM   6081 C  CB  . ILE C 1 196 ? -49.678 20.9    30.898  1    33.37  ? 192 ILE C CB  1 
ATOM   6082 C  CG1 . ILE C 1 196 ? -48.861 20.394  32.11   1    34.85  ? 192 ILE C CG1 1 
ATOM   6083 C  CG2 . ILE C 1 196 ? -48.769 21.416  29.774  1    28.31  ? 192 ILE C CG2 1 
ATOM   6084 C  CD1 . ILE C 1 196 ? -48.4   18.955  31.994  1    32.49  ? 192 ILE C CD1 1 
ATOM   6085 N  N   . PHE C 1 197 ? -52.279 22.368  29.507  1    26.56  ? 193 PHE C N   1 
ATOM   6086 C  CA  . PHE C 1 197 ? -52.913 23.208  28.503  1    25.79  ? 193 PHE C CA  1 
ATOM   6087 C  C   . PHE C 1 197 ? -53.204 24.578  29.113  1    26.28  ? 193 PHE C C   1 
ATOM   6088 O  O   . PHE C 1 197 ? -52.714 25.595  28.622  1    25.26  ? 193 PHE C O   1 
ATOM   6089 C  CB  . PHE C 1 197 ? -54.145 22.505  27.94   1    25.05  ? 193 PHE C CB  1 
ATOM   6090 C  CG  . PHE C 1 197 ? -54.881 23.203  26.809  1    25.18  ? 193 PHE C CG  1 
ATOM   6091 C  CD1 . PHE C 1 197 ? -54.313 24.277  26.127  1    24.07  ? 193 PHE C CD1 1 
ATOM   6092 C  CD2 . PHE C 1 197 ? -56.138 22.751  26.409  1    23.55  ? 193 PHE C CD2 1 
ATOM   6093 C  CE1 . PHE C 1 197 ? -55     24.887  25.082  1    26.95  ? 193 PHE C CE1 1 
ATOM   6094 C  CE2 . PHE C 1 197 ? -56.814 23.368  25.366  1    23.21  ? 193 PHE C CE2 1 
ATOM   6095 C  CZ  . PHE C 1 197 ? -56.252 24.435  24.696  1    24.47  ? 193 PHE C CZ  1 
ATOM   6096 N  N   . ALA C 1 198 ? -53.971 24.591  30.214  1    28.95  ? 194 ALA C N   1 
ATOM   6097 C  CA  . ALA C 1 198 ? -54.4   25.818  30.891  1    28.2   ? 194 ALA C CA  1 
ATOM   6098 C  C   . ALA C 1 198 ? -53.222 26.737  31.197  1    31.12  ? 194 ALA C C   1 
ATOM   6099 O  O   . ALA C 1 198 ? -53.319 27.956  31.056  1    34.08  ? 194 ALA C O   1 
ATOM   6100 C  CB  . ALA C 1 198 ? -55.142 25.471  32.16   1    23.53  ? 194 ALA C CB  1 
ATOM   6101 N  N   . GLU C 1 199 ? -52.127 26.124  31.66   1    33.3   ? 195 GLU C N   1 
ATOM   6102 C  CA  . GLU C 1 199 ? -50.941 26.82   32.137  1    32.64  ? 195 GLU C CA  1 
ATOM   6103 C  C   . GLU C 1 199 ? -50.187 27.462  30.965  1    29.44  ? 195 GLU C C   1 
ATOM   6104 O  O   . GLU C 1 199 ? -49.615 28.531  31.119  1    30.38  ? 195 GLU C O   1 
ATOM   6105 C  CB  . GLU C 1 199 ? -50.134 25.835  32.993  1    34.21  ? 195 GLU C CB  1 
ATOM   6106 C  CG  . GLU C 1 199 ? -48.998 26.451  33.805  1    33.49  ? 195 GLU C CG  1 
ATOM   6107 C  CD  . GLU C 1 199 ? -48.275 25.509  34.752  1    32.35  ? 195 GLU C CD  1 
ATOM   6108 O  OE1 . GLU C 1 199 ? -48.79  24.405  34.961  1    32.32  ? 195 GLU C OE1 1 
ATOM   6109 O  OE2 . GLU C 1 199 ? -47.206 25.876  35.286  1    35.51  ? 195 GLU C OE2 1 
ATOM   6110 N  N   . MET C 1 200 ? -50.182 26.828  29.788  1    29.16  ? 196 MET C N   1 
ATOM   6111 C  CA  . MET C 1 200 ? -49.603 27.453  28.604  1    30.58  ? 196 MET C CA  1 
ATOM   6112 C  C   . MET C 1 200 ? -50.365 28.731  28.235  1    32.36  ? 196 MET C C   1 
ATOM   6113 O  O   . MET C 1 200 ? -49.782 29.711  27.79   1    38.8   ? 196 MET C O   1 
ATOM   6114 C  CB  . MET C 1 200 ? -49.549 26.483  27.421  1    29.49  ? 196 MET C CB  1 
ATOM   6115 C  CG  . MET C 1 200 ? -48.41  25.477  27.526  1    30.09  ? 196 MET C CG  1 
ATOM   6116 S  SD  . MET C 1 200 ? -48.168 24.526  26.013  1    32.68  ? 196 MET C SD  1 
ATOM   6117 C  CE  . MET C 1 200 ? -49.464 23.28   26.056  1    28.68  ? 196 MET C CE  1 
ATOM   6118 N  N   . VAL C 1 201 ? -51.67  28.756  28.492  1    31.7   ? 197 VAL C N   1 
ATOM   6119 C  CA  . VAL C 1 201 ? -52.506 29.862  28.054  1    32.86  ? 197 VAL C CA  1 
ATOM   6120 C  C   . VAL C 1 201 ? -52.414 31.063  29.005  1    31.71  ? 197 VAL C C   1 
ATOM   6121 O  O   . VAL C 1 201 ? -52.447 32.204  28.552  1    27.79  ? 197 VAL C O   1 
ATOM   6122 C  CB  . VAL C 1 201 ? -53.964 29.377  27.918  1    34.6   ? 197 VAL C CB  1 
ATOM   6123 C  CG1 . VAL C 1 201 ? -54.916 30.558  27.776  1    36.58  ? 197 VAL C CG1 1 
ATOM   6124 C  CG2 . VAL C 1 201 ? -54.142 28.366  26.784  1    29.27  ? 197 VAL C CG2 1 
ATOM   6125 N  N   . THR C 1 202 ? -52.338 30.802  30.321  1    31.8   ? 198 THR C N   1 
ATOM   6126 C  CA  . THR C 1 202 ? -52.35  31.838  31.352  1    30.69  ? 198 THR C CA  1 
ATOM   6127 C  C   . THR C 1 202 ? -50.967 32.012  31.977  1    30.73  ? 198 THR C C   1 
ATOM   6128 O  O   . THR C 1 202 ? -50.732 33.018  32.64   1    28.67  ? 198 THR C O   1 
ATOM   6129 C  CB  . THR C 1 202 ? -53.369 31.515  32.444  1    30.31  ? 198 THR C CB  1 
ATOM   6130 O  OG1 . THR C 1 202 ? -52.8   30.434  33.178  1    35.38  ? 198 THR C OG1 1 
ATOM   6131 C  CG2 . THR C 1 202 ? -54.724 31.104  31.898  1    29.58  ? 198 THR C CG2 1 
ATOM   6132 N  N   . ARG C 1 203 ? -50.095 31.007  31.806  1    34.54  ? 199 ARG C N   1 
ATOM   6133 C  CA  . ARG C 1 203 ? -48.722 30.997  32.315  1    43.31  ? 199 ARG C CA  1 
ATOM   6134 C  C   . ARG C 1 203 ? -48.647 30.982  33.845  1    43.07  ? 199 ARG C C   1 
ATOM   6135 O  O   . ARG C 1 203 ? -47.557 31.134  34.395  1    40.89  ? 199 ARG C O   1 
ATOM   6136 C  CB  . ARG C 1 203 ? -47.857 32.135  31.755  1    48.99  ? 199 ARG C CB  1 
ATOM   6137 C  CG  . ARG C 1 203 ? -47.319 31.878  30.355  1    47.54  ? 199 ARG C CG  1 
ATOM   6138 C  CD  . ARG C 1 203 ? -47.427 33.131  29.512  1    55.11  ? 199 ARG C CD  1 
ATOM   6139 N  NE  . ARG C 1 203 ? -48.816 33.597  29.392  1    52.26  ? 199 ARG C NE  1 
ATOM   6140 C  CZ  . ARG C 1 203 ? -49.237 34.835  29.606  1    49.7   ? 199 ARG C CZ  1 
ATOM   6141 N  NH1 . ARG C 1 203 ? -48.38  35.821  29.827  1    49.59  ? 199 ARG C NH1 1 
ATOM   6142 N  NH2 . ARG C 1 203 ? -50.534 35.083  29.578  1    52.84  ? 199 ARG C NH2 1 
ATOM   6143 N  N   . ARG C 1 204 ? -49.791 30.806  34.52   1    40.83  ? 200 ARG C N   1 
ATOM   6144 C  CA  . ARG C 1 204 ? -49.789 30.412  35.919  1    36.94  ? 200 ARG C CA  1 
ATOM   6145 C  C   . ARG C 1 204 ? -50.482 29.062  35.958  1    35.92  ? 200 ARG C C   1 
ATOM   6146 O  O   . ARG C 1 204 ? -51.357 28.808  35.131  1    39.42  ? 200 ARG C O   1 
ATOM   6147 C  CB  . ARG C 1 204 ? -50.54  31.367  36.852  1    33.88  ? 200 ARG C CB  1 
ATOM   6148 C  CG  . ARG C 1 204 ? -50.89  32.706  36.234  1    34.23  ? 200 ARG C CG  1 
ATOM   6149 C  CD  . ARG C 1 204 ? -51.118 33.767  37.299  1    42.13  ? 200 ARG C CD  1 
ATOM   6150 N  NE  . ARG C 1 204 ? -51.73  34.869  36.551  1    49.01  ? 200 ARG C NE  1 
ATOM   6151 C  CZ  . ARG C 1 204 ? -51.202 36.048  36.225  1    56.06  ? 200 ARG C CZ  1 
ATOM   6152 N  NH1 . ARG C 1 204 ? -50.022 36.434  36.722  1    61.82  ? 200 ARG C NH1 1 
ATOM   6153 N  NH2 . ARG C 1 204 ? -51.897 36.845  35.415  1    47.91  ? 200 ARG C NH2 1 
ATOM   6154 N  N   . ALA C 1 205 ? -50.084 28.227  36.92   1    33.09  ? 201 ALA C N   1 
ATOM   6155 C  CA  . ALA C 1 205 ? -50.706 26.932  37.141  1    28.67  ? 201 ALA C CA  1 
ATOM   6156 C  C   . ALA C 1 205 ? -52.199 27.121  37.377  1    28.85  ? 201 ALA C C   1 
ATOM   6157 O  O   . ALA C 1 205 ? -52.616 28.133  37.938  1    31.8   ? 201 ALA C O   1 
ATOM   6158 C  CB  . ALA C 1 205 ? -50.049 26.246  38.313  1    26.63  ? 201 ALA C CB  1 
ATOM   6159 N  N   . LEU C 1 206 ? -52.982 26.129  36.951  1    27.68  ? 202 LEU C N   1 
ATOM   6160 C  CA  . LEU C 1 206 ? -54.433 26.148  37.053  1    27.2   ? 202 LEU C CA  1 
ATOM   6161 C  C   . LEU C 1 206 ? -54.876 25.852  38.484  1    25.88  ? 202 LEU C C   1 
ATOM   6162 O  O   . LEU C 1 206 ? -55.786 26.494  38.964  1    26.2   ? 202 LEU C O   1 
ATOM   6163 C  CB  . LEU C 1 206 ? -55.007 25.113  36.084  1    27.76  ? 202 LEU C CB  1 
ATOM   6164 C  CG  . LEU C 1 206 ? -56.531 24.988  36.065  1    25.7   ? 202 LEU C CG  1 
ATOM   6165 C  CD1 . LEU C 1 206 ? -57.173 26.326  35.672  1    25.09  ? 202 LEU C CD1 1 
ATOM   6166 C  CD2 . LEU C 1 206 ? -56.971 23.873  35.12   1    23.61  ? 202 LEU C CD2 1 
ATOM   6167 N  N   . PHE C 1 207 ? -54.265 24.859  39.14   1    27.03  ? 203 PHE C N   1 
ATOM   6168 C  CA  . PHE C 1 207 ? -54.66  24.429  40.475  1    27.85  ? 203 PHE C CA  1 
ATOM   6169 C  C   . PHE C 1 207 ? -53.442 24.364  41.402  1    31.71  ? 203 PHE C C   1 
ATOM   6170 O  O   . PHE C 1 207 ? -52.909 23.271  41.64   1    33.2   ? 203 PHE C O   1 
ATOM   6171 C  CB  . PHE C 1 207 ? -55.304 23.044  40.38   1    25.44  ? 203 PHE C CB  1 
ATOM   6172 C  CG  . PHE C 1 207 ? -56.542 22.995  39.501  1    24.63  ? 203 PHE C CG  1 
ATOM   6173 C  CD1 . PHE C 1 207 ? -57.577 23.904  39.659  1    23.84  ? 203 PHE C CD1 1 
ATOM   6174 C  CD2 . PHE C 1 207 ? -56.656 22.03   38.519  1    25.48  ? 203 PHE C CD2 1 
ATOM   6175 C  CE1 . PHE C 1 207 ? -58.683 23.869  38.832  1    24.29  ? 203 PHE C CE1 1 
ATOM   6176 C  CE2 . PHE C 1 207 ? -57.775 21.975  37.711  1    26.23  ? 203 PHE C CE2 1 
ATOM   6177 C  CZ  . PHE C 1 207 ? -58.79  22.884  37.883  1    26.87  ? 203 PHE C CZ  1 
ATOM   6178 N  N   . PRO C 1 208 ? -52.942 25.516  41.932  1    32.27  ? 204 PRO C N   1 
ATOM   6179 C  CA  . PRO C 1 208 ? -51.731 25.52   42.761  1    32.09  ? 204 PRO C CA  1 
ATOM   6180 C  C   . PRO C 1 208 ? -52.089 25.284  44.229  1    32.64  ? 204 PRO C C   1 
ATOM   6181 O  O   . PRO C 1 208 ? -52.188 26.23   45.008  1    41.35  ? 204 PRO C O   1 
ATOM   6182 C  CB  . PRO C 1 208 ? -51.18  26.941  42.477  1    28.11  ? 204 PRO C CB  1 
ATOM   6183 C  CG  . PRO C 1 208 ? -52.436 27.798  42.404  1    27.52  ? 204 PRO C CG  1 
ATOM   6184 C  CD  . PRO C 1 208 ? -53.489 26.877  41.756  1    29.38  ? 204 PRO C CD  1 
ATOM   6185 N  N   . GLY C 1 209 ? -52.346 24.024  44.587  1    27.72  ? 205 GLY C N   1 
ATOM   6186 C  CA  . GLY C 1 209 ? -52.715 23.716  45.958  1    30.89  ? 205 GLY C CA  1 
ATOM   6187 C  C   . GLY C 1 209 ? -51.488 23.607  46.859  1    32.38  ? 205 GLY C C   1 
ATOM   6188 O  O   . GLY C 1 209 ? -50.412 23.242  46.395  1    37.67  ? 205 GLY C O   1 
ATOM   6189 N  N   . ASP C 1 210 ? -51.671 23.885  48.151  1    36.28  ? 206 ASP C N   1 
ATOM   6190 C  CA  . ASP C 1 210 ? -50.606 23.721  49.132  1    38.9   ? 206 ASP C CA  1 
ATOM   6191 C  C   . ASP C 1 210 ? -50.95  22.602  50.117  1    32.52  ? 206 ASP C C   1 
ATOM   6192 O  O   . ASP C 1 210 ? -50.302 22.465  51.136  1    29.21  ? 206 ASP C O   1 
ATOM   6193 C  CB  . ASP C 1 210 ? -50.196 25.062  49.72   1    41.64  ? 206 ASP C CB  1 
ATOM   6194 C  CG  . ASP C 1 210 ? -51.313 25.787  50.452  1    50.81  ? 206 ASP C CG  1 
ATOM   6195 O  OD1 . ASP C 1 210 ? -52.453 25.283  50.446  1    60.81  ? 206 ASP C OD1 1 
ATOM   6196 O  OD2 . ASP C 1 210 ? -51.043 26.861  51      1    53.85  ? 206 ASP C OD2 1 
ATOM   6197 N  N   . SER C 1 211 ? -51.955 21.791  49.784  1    36.77  ? 207 SER C N   1 
ATOM   6198 C  CA  . SER C 1 211 ? -52.208 20.481  50.39   1    37.48  ? 207 SER C CA  1 
ATOM   6199 C  C   . SER C 1 211 ? -53.227 19.701  49.556  1    37.24  ? 207 SER C C   1 
ATOM   6200 O  O   . SER C 1 211 ? -53.787 20.24   48.607  1    39.21  ? 207 SER C O   1 
ATOM   6201 C  CB  . SER C 1 211 ? -52.642 20.569  51.834  1    32.13  ? 207 SER C CB  1 
ATOM   6202 O  OG  . SER C 1 211 ? -53.81  21.358  51.964  1    31.68  ? 207 SER C OG  1 
ATOM   6203 N  N   . GLU C 1 212 ? -53.476 18.434  49.911  1    42.05  ? 208 GLU C N   1 
ATOM   6204 C  CA  . GLU C 1 212 ? -54.417 17.596  49.177  1    42.65  ? 208 GLU C CA  1 
ATOM   6205 C  C   . GLU C 1 212 ? -55.841 18.129  49.315  1    43.04  ? 208 GLU C C   1 
ATOM   6206 O  O   . GLU C 1 212 ? -56.592 18.228  48.344  1    42.62  ? 208 GLU C O   1 
ATOM   6207 C  CB  . GLU C 1 212 ? -54.312 16.157  49.673  1    47.85  ? 208 GLU C CB  1 
ATOM   6208 C  CG  . GLU C 1 212 ? -53.155 15.408  49.016  1    53.29  ? 208 GLU C CG  1 
ATOM   6209 C  CD  . GLU C 1 212 ? -52.765 14.08   49.644  1    53.92  ? 208 GLU C CD  1 
ATOM   6210 O  OE1 . GLU C 1 212 ? -53.66  13.216  49.765  1    52.58  ? 208 GLU C OE1 1 
ATOM   6211 O  OE2 . GLU C 1 212 ? -51.573 13.909  50.007  1    49.45  ? 208 GLU C OE2 1 
ATOM   6212 N  N   . ILE C 1 213 ? -56.22  18.463  50.546  1    45.88  ? 209 ILE C N   1 
ATOM   6213 C  CA  . ILE C 1 213 ? -57.538 19.032  50.768  1    45     ? 209 ILE C CA  1 
ATOM   6214 C  C   . ILE C 1 213 ? -57.673 20.335  49.963  1    42.92  ? 209 ILE C C   1 
ATOM   6215 O  O   . ILE C 1 213 ? -58.685 20.556  49.299  1    41.65  ? 209 ILE C O   1 
ATOM   6216 C  CB  . ILE C 1 213 ? -57.817 19.173  52.277  1    44.42  ? 209 ILE C CB  1 
ATOM   6217 C  CG1 . ILE C 1 213 ? -59.235 19.65   52.56   1    50.73  ? 209 ILE C CG1 1 
ATOM   6218 C  CG2 . ILE C 1 213 ? -56.757 20.011  52.993  1    48.23  ? 209 ILE C CG2 1 
ATOM   6219 C  CD1 . ILE C 1 213 ? -60.274 18.54   52.487  1    53.7   ? 209 ILE C CD1 1 
ATOM   6220 N  N   . ASP C 1 214 ? -56.623 21.17   49.976  1    34.4   ? 210 ASP C N   1 
ATOM   6221 C  CA  . ASP C 1 214 ? -56.645 22.467  49.334  1    30.84  ? 210 ASP C CA  1 
ATOM   6222 C  C   . ASP C 1 214 ? -56.75  22.295  47.822  1    33.78  ? 210 ASP C C   1 
ATOM   6223 O  O   . ASP C 1 214 ? -57.422 23.078  47.15   1    34.42  ? 210 ASP C O   1 
ATOM   6224 C  CB  . ASP C 1 214 ? -55.403 23.267  49.665  1    30.85  ? 210 ASP C CB  1 
ATOM   6225 C  CG  . ASP C 1 214 ? -55.394 24.652  49.045  1    32.24  ? 210 ASP C CG  1 
ATOM   6226 O  OD1 . ASP C 1 214 ? -56.382 25.376  49.264  1    29.74  ? 210 ASP C OD1 1 
ATOM   6227 O  OD2 . ASP C 1 214 ? -54.403 24.99   48.359  1    36.57  ? 210 ASP C OD2 1 
ATOM   6228 N  N   . GLN C 1 215 ? -56.068 21.264  47.307  1    31.64  ? 211 GLN C N   1 
ATOM   6229 C  CA  . GLN C 1 215 ? -56.062 20.902  45.901  1    28.56  ? 211 GLN C CA  1 
ATOM   6230 C  C   . GLN C 1 215 ? -57.475 20.546  45.445  1    31.26  ? 211 GLN C C   1 
ATOM   6231 O  O   . GLN C 1 215 ? -57.934 21.035  44.414  1    32.11  ? 211 GLN C O   1 
ATOM   6232 C  CB  . GLN C 1 215 ? -55.152 19.69   45.733  1    28.93  ? 211 GLN C CB  1 
ATOM   6233 C  CG  . GLN C 1 215 ? -54.826 19.342  44.287  1    31.09  ? 211 GLN C CG  1 
ATOM   6234 C  CD  . GLN C 1 215 ? -53.994 20.397  43.607  1    30.34  ? 211 GLN C CD  1 
ATOM   6235 O  OE1 . GLN C 1 215 ? -53.146 21.035  44.242  1    33.54  ? 211 GLN C OE1 1 
ATOM   6236 N  NE2 . GLN C 1 215 ? -54.245 20.602  42.324  1    27.83  ? 211 GLN C NE2 1 
ATOM   6237 N  N   . LEU C 1 216 ? -58.159 19.702  46.232  1    31.84  ? 212 LEU C N   1 
ATOM   6238 C  CA  . LEU C 1 216 ? -59.537 19.345  45.959  1    29.48  ? 212 LEU C CA  1 
ATOM   6239 C  C   . LEU C 1 216 ? -60.376 20.61   45.88   1    31.44  ? 212 LEU C C   1 
ATOM   6240 O  O   . LEU C 1 216 ? -61.08  20.829  44.899  1    36.66  ? 212 LEU C O   1 
ATOM   6241 C  CB  . LEU C 1 216 ? -60.045 18.41   47.049  1    32.57  ? 212 LEU C CB  1 
ATOM   6242 C  CG  . LEU C 1 216 ? -59.715 16.93   46.853  1    37.43  ? 212 LEU C CG  1 
ATOM   6243 C  CD1 . LEU C 1 216 ? -59.965 16.128  48.102  1    34.37  ? 212 LEU C CD1 1 
ATOM   6244 C  CD2 . LEU C 1 216 ? -60.535 16.352  45.701  1    38.11  ? 212 LEU C CD2 1 
ATOM   6245 N  N   . PHE C 1 217 ? -60.303 21.444  46.922  1    32.55  ? 213 PHE C N   1 
ATOM   6246 C  CA  . PHE C 1 217 ? -61.121 22.648  46.967  1    31.45  ? 213 PHE C CA  1 
ATOM   6247 C  C   . PHE C 1 217 ? -60.854 23.524  45.742  1    30.86  ? 213 PHE C C   1 
ATOM   6248 O  O   . PHE C 1 217 ? -61.797 24.031  45.17   1    30.22  ? 213 PHE C O   1 
ATOM   6249 C  CB  . PHE C 1 217 ? -60.98  23.412  48.284  1    30.38  ? 213 PHE C CB  1 
ATOM   6250 C  CG  . PHE C 1 217 ? -61.474 22.718  49.546  1    28.37  ? 213 PHE C CG  1 
ATOM   6251 C  CD1 . PHE C 1 217 ? -61.942 21.404  49.528  1    28.12  ? 213 PHE C CD1 1 
ATOM   6252 C  CD2 . PHE C 1 217 ? -61.409 23.375  50.766  1    25.27  ? 213 PHE C CD2 1 
ATOM   6253 C  CE1 . PHE C 1 217 ? -62.371 20.789  50.694  1    25.29  ? 213 PHE C CE1 1 
ATOM   6254 C  CE2 . PHE C 1 217 ? -61.818 22.746  51.928  1    25.16  ? 213 PHE C CE2 1 
ATOM   6255 C  CZ  . PHE C 1 217 ? -62.309 21.459  51.893  1    24.56  ? 213 PHE C CZ  1 
ATOM   6256 N  N   . ARG C 1 218 ? -59.586 23.653  45.316  1    34.93  ? 214 ARG C N   1 
ATOM   6257 C  CA  . ARG C 1 218 ? -59.198 24.493  44.183  1    31.02  ? 214 ARG C CA  1 
ATOM   6258 C  C   . ARG C 1 218 ? -59.834 24.031  42.872  1    32.85  ? 214 ARG C C   1 
ATOM   6259 O  O   . ARG C 1 218 ? -60.112 24.867  42.007  1    31.51  ? 214 ARG C O   1 
ATOM   6260 C  CB  . ARG C 1 218 ? -57.68  24.531  44.007  1    28.52  ? 214 ARG C CB  1 
ATOM   6261 C  CG  . ARG C 1 218 ? -57.043 25.531  44.958  1    31.4   ? 214 ARG C CG  1 
ATOM   6262 C  CD  . ARG C 1 218 ? -55.531 25.439  45.069  1    30.29  ? 214 ARG C CD  1 
ATOM   6263 N  NE  . ARG C 1 218 ? -55.047 26.466  45.992  1    28.94  ? 214 ARG C NE  1 
ATOM   6264 C  CZ  . ARG C 1 218 ? -55.064 27.737  45.691  1    29.33  ? 214 ARG C CZ  1 
ATOM   6265 N  NH1 . ARG C 1 218 ? -55.348 28.079  44.439  1    31.32  ? 214 ARG C NH1 1 
ATOM   6266 N  NH2 . ARG C 1 218 ? -54.745 28.623  46.625  1    26.86  ? 214 ARG C NH2 1 
ATOM   6267 N  N   . ILE C 1 219 ? -60.037 22.712  42.744  1    32.64  ? 215 ILE C N   1 
ATOM   6268 C  CA  . ILE C 1 219 ? -60.62  22.079  41.569  1    37.27  ? 215 ILE C CA  1 
ATOM   6269 C  C   . ILE C 1 219 ? -62.14  22.297  41.551  1    41.55  ? 215 ILE C C   1 
ATOM   6270 O  O   . ILE C 1 219 ? -62.704 22.793  40.562  1    41.59  ? 215 ILE C O   1 
ATOM   6271 C  CB  . ILE C 1 219 ? -60.219 20.591  41.519  1    33.57  ? 215 ILE C CB  1 
ATOM   6272 C  CG1 . ILE C 1 219 ? -58.689 20.437  41.286  1    29.82  ? 215 ILE C CG1 1 
ATOM   6273 C  CG2 . ILE C 1 219 ? -61.036 19.854  40.455  1    32.55  ? 215 ILE C CG2 1 
ATOM   6274 C  CD1 . ILE C 1 219 ? -58.104 19.099  41.713  1    26.98  ? 215 ILE C CD1 1 
ATOM   6275 N  N   . PHE C 1 220 ? -62.79  21.924  42.649  1    40.99  ? 216 PHE C N   1 
ATOM   6276 C  CA  . PHE C 1 220 ? -64.259 22.084  42.759  1    38.61  ? 216 PHE C CA  1 
ATOM   6277 C  C   . PHE C 1 220 ? -64.626 23.502  42.41   1    36.37  ? 216 PHE C C   1 
ATOM   6278 O  O   . PHE C 1 220 ? -65.447 23.729  41.527  1    41.81  ? 216 PHE C O   1 
ATOM   6279 C  CB  . PHE C 1 220 ? -64.563 21.705  44.205  1    33.72  ? 216 PHE C CB  1 
ATOM   6280 C  CG  . PHE C 1 220 ? -64.295 20.248  44.539  1    37.53  ? 216 PHE C CG  1 
ATOM   6281 C  CD1 . PHE C 1 220 ? -64.218 19.289  43.538  1    33.87  ? 216 PHE C CD1 1 
ATOM   6282 C  CD2 . PHE C 1 220 ? -64.129 19.841  45.855  1    41.54  ? 216 PHE C CD2 1 
ATOM   6283 C  CE1 . PHE C 1 220 ? -63.974 17.965  43.847  1    40.62  ? 216 PHE C CE1 1 
ATOM   6284 C  CE2 . PHE C 1 220 ? -63.886 18.514  46.158  1    46.65  ? 216 PHE C CE2 1 
ATOM   6285 C  CZ  . PHE C 1 220 ? -63.812 17.581  45.154  1    44.46  ? 216 PHE C CZ  1 
ATOM   6286 N  N   . ARG C 1 221 ? -63.991 24.455  43.072  1    35.94  ? 217 ARG C N   1 
ATOM   6287 C  CA  . ARG C 1 221 ? -64.292 25.884  42.838  1    42.02  ? 217 ARG C CA  1 
ATOM   6288 C  C   . ARG C 1 221 ? -64.376 26.187  41.341  1    45.87  ? 217 ARG C C   1 
ATOM   6289 O  O   . ARG C 1 221 ? -65.363 26.818  40.925  1    48.55  ? 217 ARG C O   1 
ATOM   6290 C  CB  . ARG C 1 221 ? -63.174 26.736  43.437  1    40.72  ? 217 ARG C CB  1 
ATOM   6291 C  CG  . ARG C 1 221 ? -63.321 27.117  44.902  1    55.85  ? 217 ARG C CG  1 
ATOM   6292 C  CD  . ARG C 1 221 ? -62.24  28.096  45.332  1    60.65  ? 217 ARG C CD  1 
ATOM   6293 N  NE  . ARG C 1 221 ? -60.898 27.671  44.922  1    63.1   ? 217 ARG C NE  1 
ATOM   6294 C  CZ  . ARG C 1 221 ? -60.128 28.328  44.068  1    68.14  ? 217 ARG C CZ  1 
ATOM   6295 N  NH1 . ARG C 1 221 ? -59.774 27.765  42.927  1    77.01  ? 217 ARG C NH1 1 
ATOM   6296 N  NH2 . ARG C 1 221 ? -59.718 29.549  44.354  1    59.7   ? 217 ARG C NH2 1 
ATOM   6297 N  N   . THR C 1 222 ? -63.386 25.757  40.562  1    48.25  ? 218 THR C N   1 
ATOM   6298 C  CA  . THR C 1 222 ? -63.34  26.145  39.14   1    48.17  ? 218 THR C CA  1 
ATOM   6299 C  C   . THR C 1 222 ? -64.24  25.264  38.315  1    46.28  ? 218 THR C C   1 
ATOM   6300 O  O   . THR C 1 222 ? -64.913 25.8    37.417  1    41.54  ? 218 THR C O   1 
ATOM   6301 C  CB  . THR C 1 222 ? -61.886 26.074  38.678  1    51.01  ? 218 THR C CB  1 
ATOM   6302 O  OG1 . THR C 1 222 ? -61.253 27.192  39.289  1    49.38  ? 218 THR C OG1 1 
ATOM   6303 C  CG2 . THR C 1 222 ? -61.732 26.15   37.17   1    45.4   ? 218 THR C CG2 1 
ATOM   6304 N  N   . LEU C 1 223 ? -64.301 23.971  38.62   1    46.15  ? 219 LEU C N   1 
ATOM   6305 C  CA  . LEU C 1 223 ? -65.051 23.063  37.715  1    51.06  ? 219 LEU C CA  1 
ATOM   6306 C  C   . LEU C 1 223 ? -66.438 22.742  38.284  1    54.24  ? 219 LEU C C   1 
ATOM   6307 O  O   . LEU C 1 223 ? -67.241 22.119  37.565  1    63.92  ? 219 LEU C O   1 
ATOM   6308 C  CB  . LEU C 1 223 ? -64.23  21.796  37.476  1    47.86  ? 219 LEU C CB  1 
ATOM   6309 C  CG  . LEU C 1 223 ? -62.773 22.002  37.056  1    45.01  ? 219 LEU C CG  1 
ATOM   6310 C  CD1 . LEU C 1 223 ? -62.096 20.654  36.943  1    40.45  ? 219 LEU C CD1 1 
ATOM   6311 C  CD2 . LEU C 1 223 ? -62.692 22.747  35.738  1    42.8   ? 219 LEU C CD2 1 
ATOM   6312 N  N   . GLY C 1 224 ? -66.7   23.148  39.521  1    54.75  ? 220 GLY C N   1 
ATOM   6313 C  CA  . GLY C 1 224 ? -67.999 22.862  40.149  1    47.95  ? 220 GLY C CA  1 
ATOM   6314 C  C   . GLY C 1 224 ? -67.873 21.675  41.069  1    49.23  ? 220 GLY C C   1 
ATOM   6315 O  O   . GLY C 1 224 ? -67.226 20.697  40.668  1    48.68  ? 220 GLY C O   1 
ATOM   6316 N  N   . PHE C 1 252 ? -64.412 27.827  31.889  1    41.76  ? 248 PHE C N   1 
ATOM   6317 C  CA  . PHE C 1 252 ? -65.211 29.029  31.519  1    63.83  ? 248 PHE C CA  1 
ATOM   6318 C  C   . PHE C 1 252 ? -64.298 30.065  30.887  1    71.51  ? 248 PHE C C   1 
ATOM   6319 O  O   . PHE C 1 252 ? -63.061 29.957  30.97   1    70.48  ? 248 PHE C O   1 
ATOM   6320 C  CB  . PHE C 1 252 ? -65.916 29.748  32.673  1    63.82  ? 248 PHE C CB  1 
ATOM   6321 C  CG  . PHE C 1 252 ? -66.541 28.881  33.756  1    73.24  ? 248 PHE C CG  1 
ATOM   6322 C  CD1 . PHE C 1 252 ? -67.301 27.763  33.432  1    73.38  ? 248 PHE C CD1 1 
ATOM   6323 C  CD2 . PHE C 1 252 ? -66.384 29.199  35.099  1    72.99  ? 248 PHE C CD2 1 
ATOM   6324 C  CE1 . PHE C 1 252 ? -67.869 26.983  34.425  1    68.18  ? 248 PHE C CE1 1 
ATOM   6325 C  CE2 . PHE C 1 252 ? -66.956 28.416  36.087  1    74.34  ? 248 PHE C CE2 1 
ATOM   6326 C  CZ  . PHE C 1 252 ? -67.697 27.31   35.75   1    66.62  ? 248 PHE C CZ  1 
ATOM   6327 N  N   . SER C 1 253 ? -64.909 31.082  30.284  1    82.78  ? 249 SER C N   1 
ATOM   6328 C  CA  . SER C 1 253 ? -64.122 32.156  29.635  1    85.76  ? 249 SER C CA  1 
ATOM   6329 C  C   . SER C 1 253 ? -63.442 32.999  30.718  1    93.98  ? 249 SER C C   1 
ATOM   6330 O  O   . SER C 1 253 ? -62.658 33.896  30.363  1    96.57  ? 249 SER C O   1 
ATOM   6331 C  CB  . SER C 1 253 ? -64.991 32.994  28.751  1    74.85  ? 249 SER C CB  1 
ATOM   6332 O  OG  . SER C 1 253 ? -65.96  32.191  28.092  1    67.92  ? 249 SER C OG  1 
ATOM   6333 N  N   . LYS C 1 254 ? -63.75  32.736  31.984  1    94.25  ? 250 LYS C N   1 
ATOM   6334 C  CA  . LYS C 1 254 ? -63.031 33.444  33.07   1    94.25  ? 250 LYS C CA  1 
ATOM   6335 C  C   . LYS C 1 254 ? -61.806 32.599  33.424  1    80.57  ? 250 LYS C C   1 
ATOM   6336 O  O   . LYS C 1 254 ? -60.773 33.187  33.787  1    71.04  ? 250 LYS C O   1 
ATOM   6337 C  CB  . LYS C 1 254 ? -63.934 33.652  34.289  1    98.82  ? 250 LYS C CB  1 
ATOM   6338 C  CG  . LYS C 1 254 ? -65.098 34.602  34.081  1    94.66  ? 250 LYS C CG  1 
ATOM   6339 C  CD  . LYS C 1 254 ? -65.974 34.75   35.318  1    84.55  ? 250 LYS C CD  1 
ATOM   6340 C  CE  . LYS C 1 254 ? -67.099 35.708  35.097  1    77.51  ? 250 LYS C CE  1 
ATOM   6341 N  NZ  . LYS C 1 254 ? -67.948 35.825  36.285  1    71.49  ? 250 LYS C NZ  1 
ATOM   6342 N  N   . VAL C 1 255 ? -61.933 31.277  33.302  1    73.52  ? 251 VAL C N   1 
ATOM   6343 C  CA  . VAL C 1 255 ? -60.815 30.356  33.648  1    73.95  ? 251 VAL C CA  1 
ATOM   6344 C  C   . VAL C 1 255 ? -59.684 30.56   32.638  1    66.84  ? 251 VAL C C   1 
ATOM   6345 O  O   . VAL C 1 255 ? -58.526 30.712  33.066  1    65.39  ? 251 VAL C O   1 
ATOM   6346 C  CB  . VAL C 1 255 ? -61.332 28.909  33.62   1    80.44  ? 251 VAL C CB  1 
ATOM   6347 C  CG1 . VAL C 1 255 ? -60.219 27.895  33.843  1    79.74  ? 251 VAL C CG1 1 
ATOM   6348 C  CG2 . VAL C 1 255 ? -62.47  28.704  34.611  1    80.47  ? 251 VAL C CG2 1 
ATOM   6349 N  N   . VAL C 1 256 ? -60.02  30.57   31.353  1    65.22  ? 252 VAL C N   1 
ATOM   6350 C  CA  . VAL C 1 256 ? -58.976 30.693  30.298  1    64.31  ? 252 VAL C CA  1 
ATOM   6351 C  C   . VAL C 1 256 ? -59.437 31.748  29.285  1    62.58  ? 252 VAL C C   1 
ATOM   6352 O  O   . VAL C 1 256 ? -59.873 31.382  28.179  1    59.45  ? 252 VAL C O   1 
ATOM   6353 C  CB  . VAL C 1 256 ? -58.755 29.318  29.648  1    57.84  ? 252 VAL C CB  1 
ATOM   6354 C  CG1 . VAL C 1 256 ? -57.787 29.401  28.476  1    63.37  ? 252 VAL C CG1 1 
ATOM   6355 C  CG2 . VAL C 1 256 ? -58.287 28.285  30.665  1    52.78  ? 252 VAL C CG2 1 
ATOM   6356 N  N   . PRO C 1 257 ? -59.366 33.049  29.618  1    63.1   ? 253 PRO C N   1 
ATOM   6357 C  CA  . PRO C 1 257 ? -59.87  34.069  28.714  1    56.1   ? 253 PRO C CA  1 
ATOM   6358 C  C   . PRO C 1 257 ? -59.391 33.999  27.264  1    56.87  ? 253 PRO C C   1 
ATOM   6359 O  O   . PRO C 1 257 ? -60.26  33.981  26.378  1    55.86  ? 253 PRO C O   1 
ATOM   6360 C  CB  . PRO C 1 257 ? -59.425 35.348  29.437  1    48.88  ? 253 PRO C CB  1 
ATOM   6361 C  CG  . PRO C 1 257 ? -59.422 34.96   30.892  1    48.2   ? 253 PRO C CG  1 
ATOM   6362 C  CD  . PRO C 1 257 ? -58.825 33.57   30.86   1    59.95  ? 253 PRO C CD  1 
ATOM   6363 N  N   . PRO C 1 258 ? -58.081 33.928  26.939  1    56.01  ? 254 PRO C N   1 
ATOM   6364 C  CA  . PRO C 1 258 ? -57.652 33.982  25.549  1    52.49  ? 254 PRO C CA  1 
ATOM   6365 C  C   . PRO C 1 258 ? -58.077 32.791  24.725  1    56.51  ? 254 PRO C C   1 
ATOM   6366 O  O   . PRO C 1 258 ? -57.841 32.796  23.507  1    63.04  ? 254 PRO C O   1 
ATOM   6367 C  CB  . PRO C 1 258 ? -56.128 34.046  25.665  1    48.18  ? 254 PRO C CB  1 
ATOM   6368 C  CG  . PRO C 1 258 ? -55.875 34.5    27.078  1    48.53  ? 254 PRO C CG  1 
ATOM   6369 C  CD  . PRO C 1 258 ? -56.955 33.783  27.848  1    52.41  ? 254 PRO C CD  1 
ATOM   6370 N  N   . LEU C 1 259 ? -58.695 31.795  25.352  1    52.49  ? 255 LEU C N   1 
ATOM   6371 C  CA  . LEU C 1 259 ? -59.017 30.548  24.619  1    50.13  ? 255 LEU C CA  1 
ATOM   6372 C  C   . LEU C 1 259 ? -60.289 30.718  23.788  1    52.56  ? 255 LEU C C   1 
ATOM   6373 O  O   . LEU C 1 259 ? -61.186 31.466  24.216  1    56.58  ? 255 LEU C O   1 
ATOM   6374 C  CB  . LEU C 1 259 ? -59.149 29.398  25.615  1    44.66  ? 255 LEU C CB  1 
ATOM   6375 C  CG  . LEU C 1 259 ? -58.542 28.063  25.178  1    44.45  ? 255 LEU C CG  1 
ATOM   6376 C  CD1 . LEU C 1 259 ? -57.328 28.285  24.298  1    41.13  ? 255 LEU C CD1 1 
ATOM   6377 C  CD2 . LEU C 1 259 ? -58.184 27.215  26.381  1    41.82  ? 255 LEU C CD2 1 
ATOM   6378 N  N   . ASP C 1 260 ? -60.356 30.026  22.654  1    56.74  ? 256 ASP C N   1 
ATOM   6379 C  CA  . ASP C 1 260 ? -61.572 30.055  21.807  1    61.35  ? 256 ASP C CA  1 
ATOM   6380 C  C   . ASP C 1 260 ? -62.588 29.04   22.325  1    60.78  ? 256 ASP C C   1 
ATOM   6381 O  O   . ASP C 1 260 ? -62.332 28.405  23.366  1    58.14  ? 256 ASP C O   1 
ATOM   6382 C  CB  . ASP C 1 260 ? -61.25  29.722  20.362  1    60.68  ? 256 ASP C CB  1 
ATOM   6383 C  CG  . ASP C 1 260 ? -60.399 28.48   20.145  1    58.8   ? 256 ASP C CG  1 
ATOM   6384 O  OD1 . ASP C 1 260 ? -59.441 28.285  20.918  1    53.01  ? 256 ASP C OD1 1 
ATOM   6385 O  OD2 . ASP C 1 260 ? -60.697 27.727  19.199  1    53.79  ? 256 ASP C OD2 1 
ATOM   6386 N  N   . GLU C 1 261 ? -63.685 28.876  21.594  1    54.08  ? 257 GLU C N   1 
ATOM   6387 C  CA  . GLU C 1 261 ? -64.741 27.92   21.997  1    54.39  ? 257 GLU C CA  1 
ATOM   6388 C  C   . GLU C 1 261 ? -64.217 26.495  21.814  1    51.9   ? 257 GLU C C   1 
ATOM   6389 O  O   . GLU C 1 261 ? -64.549 25.63   22.641  1    50.02  ? 257 GLU C O   1 
ATOM   6390 C  CB  . GLU C 1 261 ? -65.97  28.211  21.14   1    53.38  ? 257 GLU C CB  1 
ATOM   6391 C  CG  . GLU C 1 261 ? -67.235 27.525  21.645  1    62.39  ? 257 GLU C CG  1 
ATOM   6392 C  CD  . GLU C 1 261 ? -67.991 26.785  20.558  1    67.57  ? 257 GLU C CD  1 
ATOM   6393 O  OE1 . GLU C 1 261 ? -67.86  25.546  20.48   1    65.14  ? 257 GLU C OE1 1 
ATOM   6394 O  OE2 . GLU C 1 261 ? -68.711 27.452  19.788  1    67.31  ? 257 GLU C OE2 1 
ATOM   6395 N  N   . ASP C 1 262 ? -63.44  26.268  20.759  1    44.4   ? 258 ASP C N   1 
ATOM   6396 C  CA  . ASP C 1 262 ? -62.866 24.953  20.541  1    41.55  ? 258 ASP C CA  1 
ATOM   6397 C  C   . ASP C 1 262 ? -61.843 24.642  21.641  1    45.51  ? 258 ASP C C   1 
ATOM   6398 O  O   . ASP C 1 262 ? -61.794 23.522  22.163  1    43.27  ? 258 ASP C O   1 
ATOM   6399 C  CB  . ASP C 1 262 ? -62.277 24.856  19.142  1    41.85  ? 258 ASP C CB  1 
ATOM   6400 C  CG  . ASP C 1 262 ? -63.278 24.677  18.012  1    41.6   ? 258 ASP C CG  1 
ATOM   6401 O  OD1 . ASP C 1 262 ? -64.461 24.383  18.308  1    36.95  ? 258 ASP C OD1 1 
ATOM   6402 O  OD2 . ASP C 1 262 ? -62.852 24.822  16.849  1    40.51  ? 258 ASP C OD2 1 
ATOM   6403 N  N   . GLY C 1 263 ? -61.015 25.639  21.989  1    38.93  ? 259 GLY C N   1 
ATOM   6404 C  CA  . GLY C 1 263 ? -60.039 25.445  23.038  1    36.05  ? 259 GLY C CA  1 
ATOM   6405 C  C   . GLY C 1 263 ? -60.732 25.102  24.355  1    38.74  ? 259 GLY C C   1 
ATOM   6406 O  O   . GLY C 1 263 ? -60.329 24.187  25.066  1    44.47  ? 259 GLY C O   1 
ATOM   6407 N  N   . ARG C 1 264 ? -61.78  25.855  24.683  1    42.31  ? 260 ARG C N   1 
ATOM   6408 C  CA  . ARG C 1 264 ? -62.488 25.655  25.935  1    42.79  ? 260 ARG C CA  1 
ATOM   6409 C  C   . ARG C 1 264 ? -63.098 24.257  25.966  1    36.34  ? 260 ARG C C   1 
ATOM   6410 O  O   . ARG C 1 264 ? -63.131 23.62   27.015  1    37.87  ? 260 ARG C O   1 
ATOM   6411 C  CB  . ARG C 1 264 ? -63.563 26.73   26.138  1    50.72  ? 260 ARG C CB  1 
ATOM   6412 C  CG  . ARG C 1 264 ? -63.042 28.079  26.615  1    59.79  ? 260 ARG C CG  1 
ATOM   6413 C  CD  . ARG C 1 264 ? -64.173 28.952  27.175  1    64.22  ? 260 ARG C CD  1 
ATOM   6414 N  NE  . ARG C 1 264 ? -65.122 29.383  26.135  1    62.24  ? 260 ARG C NE  1 
ATOM   6415 C  CZ  . ARG C 1 264 ? -64.898 30.317  25.202  1    56.48  ? 260 ARG C CZ  1 
ATOM   6416 N  NH1 . ARG C 1 264 ? -63.749 30.974  25.172  1    61.87  ? 260 ARG C NH1 1 
ATOM   6417 N  NH2 . ARG C 1 264 ? -65.818 30.599  24.296  1    42.9   ? 260 ARG C NH2 1 
ATOM   6418 N  N   . SER C 1 265 ? -63.588 23.804  24.812  1    32.73  ? 261 SER C N   1 
ATOM   6419 C  CA  . SER C 1 265 ? -64.285 22.534  24.702  1    33.01  ? 261 SER C CA  1 
ATOM   6420 C  C   . SER C 1 265 ? -63.332 21.365  24.964  1    33.95  ? 261 SER C C   1 
ATOM   6421 O  O   . SER C 1 265 ? -63.618 20.469  25.765  1    33.05  ? 261 SER C O   1 
ATOM   6422 C  CB  . SER C 1 265 ? -64.948 22.435  23.354  1    33.03  ? 261 SER C CB  1 
ATOM   6423 O  OG  . SER C 1 265 ? -65.446 21.127  23.134  1    34.63  ? 261 SER C OG  1 
ATOM   6424 N  N   . LEU C 1 266 ? -62.184 21.387  24.28   1    35.5   ? 262 LEU C N   1 
ATOM   6425 C  CA  . LEU C 1 266 ? -61.153 20.385  24.49   1    36.3   ? 262 LEU C CA  1 
ATOM   6426 C  C   . LEU C 1 266 ? -60.724 20.372  25.963  1    37.13  ? 262 LEU C C   1 
ATOM   6427 O  O   . LEU C 1 266 ? -60.602 19.298  26.56   1    37.69  ? 262 LEU C O   1 
ATOM   6428 C  CB  . LEU C 1 266 ? -59.991 20.65   23.528  1    36.33  ? 262 LEU C CB  1 
ATOM   6429 C  CG  . LEU C 1 266 ? -58.714 19.82   23.751  1    35.45  ? 262 LEU C CG  1 
ATOM   6430 C  CD1 . LEU C 1 266 ? -58.994 18.341  23.712  1    31.64  ? 262 LEU C CD1 1 
ATOM   6431 C  CD2 . LEU C 1 266 ? -57.666 20.163  22.707  1    33.7   ? 262 LEU C CD2 1 
ATOM   6432 N  N   . LEU C 1 267 ? -60.502 21.566  26.534  1    36.15  ? 263 LEU C N   1 
ATOM   6433 C  CA  . LEU C 1 267 ? -60.023 21.702  27.901  1    35.35  ? 263 LEU C CA  1 
ATOM   6434 C  C   . LEU C 1 267 ? -60.981 20.98   28.845  1    36.23  ? 263 LEU C C   1 
ATOM   6435 O  O   . LEU C 1 267 ? -60.568 20.074  29.582  1    36.14  ? 263 LEU C O   1 
ATOM   6436 C  CB  . LEU C 1 267 ? -59.822 23.171  28.283  1    34.23  ? 263 LEU C CB  1 
ATOM   6437 C  CG  . LEU C 1 267 ? -59.292 23.452  29.698  1    34.12  ? 263 LEU C CG  1 
ATOM   6438 C  CD1 . LEU C 1 267 ? -57.971 22.723  29.987  1    33.38  ? 263 LEU C CD1 1 
ATOM   6439 C  CD2 . LEU C 1 267 ? -59.083 24.932  29.937  1    29.39  ? 263 LEU C CD2 1 
ATOM   6440 N  N   . SER C 1 268 ? -62.264 21.37   28.791  1    34.9   ? 264 SER C N   1 
ATOM   6441 C  CA  . SER C 1 268 ? -63.27  20.78   29.667  1    35.76  ? 264 SER C CA  1 
ATOM   6442 C  C   . SER C 1 268 ? -63.282 19.256  29.534  1    37.51  ? 264 SER C C   1 
ATOM   6443 O  O   . SER C 1 268 ? -63.323 18.553  30.538  1    41.15  ? 264 SER C O   1 
ATOM   6444 C  CB  . SER C 1 268 ? -64.631 21.389  29.472  1    31.78  ? 264 SER C CB  1 
ATOM   6445 O  OG  . SER C 1 268 ? -64.946 21.42   28.093  1    36.86  ? 264 SER C OG  1 
ATOM   6446 N  N   . GLN C 1 269 ? -63.191 18.754  28.298  1    33.99  ? 265 GLN C N   1 
ATOM   6447 C  CA  . GLN C 1 269 ? -63.184 17.321  28.055  1    34.21  ? 265 GLN C CA  1 
ATOM   6448 C  C   . GLN C 1 269 ? -61.962 16.662  28.702  1    37.25  ? 265 GLN C C   1 
ATOM   6449 O  O   . GLN C 1 269 ? -62.037 15.517  29.157  1    42.08  ? 265 GLN C O   1 
ATOM   6450 C  CB  . GLN C 1 269 ? -63.289 17.058  26.555  1    31.88  ? 265 GLN C CB  1 
ATOM   6451 C  CG  . GLN C 1 269 ? -64.675 17.344  25.995  1    31.95  ? 265 GLN C CG  1 
ATOM   6452 C  CD  . GLN C 1 269 ? -64.753 17.154  24.496  1    36.58  ? 265 GLN C CD  1 
ATOM   6453 O  OE1 . GLN C 1 269 ? -65.058 18.083  23.738  1    39.15  ? 265 GLN C OE1 1 
ATOM   6454 N  NE2 . GLN C 1 269 ? -64.47  15.943  24.039  1    38.32  ? 265 GLN C NE2 1 
ATOM   6455 N  N   . MET C 1 270 ? -60.829 17.38   28.744  1    35.5   ? 266 MET C N   1 
ATOM   6456 C  CA  . MET C 1 270 ? -59.622 16.839  29.358  1    35.69  ? 266 MET C CA  1 
ATOM   6457 C  C   . MET C 1 270 ? -59.702 16.938  30.879  1    34.84  ? 266 MET C C   1 
ATOM   6458 O  O   . MET C 1 270 ? -58.982 16.246  31.591  1    33.47  ? 266 MET C O   1 
ATOM   6459 C  CB  . MET C 1 270 ? -58.36  17.57   28.879  1    32.69  ? 266 MET C CB  1 
ATOM   6460 C  CG  . MET C 1 270 ? -58.019 17.23   27.464  1    30.37  ? 266 MET C CG  1 
ATOM   6461 S  SD  . MET C 1 270 ? -56.768 18.352  26.832  1    34.24  ? 266 MET C SD  1 
ATOM   6462 C  CE  . MET C 1 270 ? -55.262 17.572  27.437  1    28.48  ? 266 MET C CE  1 
ATOM   6463 N  N   . LEU C 1 271 ? -60.555 17.833  31.367  1    34.57  ? 267 LEU C N   1 
ATOM   6464 C  CA  . LEU C 1 271 ? -60.632 18.048  32.798  1    37.69  ? 267 LEU C CA  1 
ATOM   6465 C  C   . LEU C 1 271 ? -61.935 17.494  33.381  1    38.89  ? 267 LEU C C   1 
ATOM   6466 O  O   . LEU C 1 271 ? -62.317 17.861  34.481  1    43.02  ? 267 LEU C O   1 
ATOM   6467 C  CB  . LEU C 1 271 ? -60.461 19.547  33.053  1    37.23  ? 267 LEU C CB  1 
ATOM   6468 C  CG  . LEU C 1 271 ? -59.027 20.078  33.024  1    36.96  ? 267 LEU C CG  1 
ATOM   6469 C  CD1 . LEU C 1 271 ? -59.049 21.551  33.412  1    35.52  ? 267 LEU C CD1 1 
ATOM   6470 C  CD2 . LEU C 1 271 ? -58.067 19.263  33.911  1    36.47  ? 267 LEU C CD2 1 
ATOM   6471 N  N   . HIS C 1 272 ? -62.6   16.578  32.672  1    42.82  ? 268 HIS C N   1 
ATOM   6472 C  CA  . HIS C 1 272 ? -63.831 15.979  33.166  1    44.81  ? 268 HIS C CA  1 
ATOM   6473 C  C   . HIS C 1 272 ? -63.525 15.219  34.46   1    43.12  ? 268 HIS C C   1 
ATOM   6474 O  O   . HIS C 1 272 ? -62.449 14.648  34.618  1    41.8   ? 268 HIS C O   1 
ATOM   6475 C  CB  . HIS C 1 272 ? -64.467 15.112  32.07   1    51.03  ? 268 HIS C CB  1 
ATOM   6476 C  CG  . HIS C 1 272 ? -65.912 14.769  32.278  1    63.57  ? 268 HIS C CG  1 
ATOM   6477 N  ND1 . HIS C 1 272 ? -66.464 14.348  33.475  1    65.9   ? 268 HIS C ND1 1 
ATOM   6478 C  CD2 . HIS C 1 272 ? -66.921 14.786  31.391  1    65.05  ? 268 HIS C CD2 1 
ATOM   6479 C  CE1 . HIS C 1 272 ? -67.763 14.132  33.313  1    62.53  ? 268 HIS C CE1 1 
ATOM   6480 N  NE2 . HIS C 1 272 ? -68.064 14.396  32.056  1    68.61  ? 268 HIS C NE2 1 
ATOM   6481 N  N   . TYR C 1 273 ? -64.469 15.221  35.404  1    42.29  ? 269 TYR C N   1 
ATOM   6482 C  CA  . TYR C 1 273 ? -64.228 14.58   36.687  1    40.43  ? 269 TYR C CA  1 
ATOM   6483 C  C   . TYR C 1 273 ? -64.209 13.06   36.544  1    39.52  ? 269 TYR C C   1 
ATOM   6484 O  O   . TYR C 1 273 ? -63.296 12.397  37.022  1    35.27  ? 269 TYR C O   1 
ATOM   6485 C  CB  . TYR C 1 273 ? -65.35  14.962  37.646  1    41.87  ? 269 TYR C CB  1 
ATOM   6486 C  CG  . TYR C 1 273 ? -65.166 16.315  38.304  1    49.33  ? 269 TYR C CG  1 
ATOM   6487 C  CD1 . TYR C 1 273 ? -64.186 16.492  39.274  1    46.06  ? 269 TYR C CD1 1 
ATOM   6488 C  CD2 . TYR C 1 273 ? -66.007 17.39   38.005  1    52.32  ? 269 TYR C CD2 1 
ATOM   6489 C  CE1 . TYR C 1 273 ? -64.022 17.715  39.903  1    47.07  ? 269 TYR C CE1 1 
ATOM   6490 C  CE2 . TYR C 1 273 ? -65.854 18.616  38.643  1    56.31  ? 269 TYR C CE2 1 
ATOM   6491 C  CZ  . TYR C 1 273 ? -64.863 18.778  39.605  1    55.58  ? 269 TYR C CZ  1 
ATOM   6492 O  OH  . TYR C 1 273 ? -64.71  19.979  40.26   1    54.32  ? 269 TYR C OH  1 
ATOM   6493 N  N   . ASP C 1 274 ? -65.256 12.507  35.931  1    38.14  ? 270 ASP C N   1 
ATOM   6494 C  CA  . ASP C 1 274 ? -65.353 11.077  35.727  1    41.95  ? 270 ASP C CA  1 
ATOM   6495 C  C   . ASP C 1 274 ? -64.176 10.647  34.851  1    43.86  ? 270 ASP C C   1 
ATOM   6496 O  O   . ASP C 1 274 ? -64.053 11.104  33.715  1    45.12  ? 270 ASP C O   1 
ATOM   6497 C  CB  . ASP C 1 274 ? -66.719 10.705  35.161  1    41.87  ? 270 ASP C CB  1 
ATOM   6498 C  CG  . ASP C 1 274 ? -67.023 9.218   35.022  1    46.06  ? 270 ASP C CG  1 
ATOM   6499 O  OD1 . ASP C 1 274 ? -66.119 8.38    35.25   1    46.85  ? 270 ASP C OD1 1 
ATOM   6500 O  OD2 . ASP C 1 274 ? -68.179 8.898   34.696  1    54.21  ? 270 ASP C OD2 1 
ATOM   6501 N  N   . PRO C 1 275 ? -63.264 9.781   35.357  1    39.57  ? 271 PRO C N   1 
ATOM   6502 C  CA  . PRO C 1 275 ? -62.189 9.222   34.537  1    39.4   ? 271 PRO C CA  1 
ATOM   6503 C  C   . PRO C 1 275 ? -62.651 8.526   33.254  1    41.5   ? 271 PRO C C   1 
ATOM   6504 O  O   . PRO C 1 275 ? -61.9   8.472   32.273  1    42.16  ? 271 PRO C O   1 
ATOM   6505 C  CB  . PRO C 1 275 ? -61.533 8.229   35.503  1    38.65  ? 271 PRO C CB  1 
ATOM   6506 C  CG  . PRO C 1 275 ? -61.78  8.822   36.858  1    38.11  ? 271 PRO C CG  1 
ATOM   6507 C  CD  . PRO C 1 275 ? -63.199 9.335   36.756  1    38.1   ? 271 PRO C CD  1 
ATOM   6508 N  N   . ASN C 1 276 ? -63.888 8.002   33.272  1    41.05  ? 272 ASN C N   1 
ATOM   6509 C  CA  . ASN C 1 276 ? -64.452 7.261   32.154  1    35.48  ? 272 ASN C CA  1 
ATOM   6510 C  C   . ASN C 1 276 ? -64.944 8.215   31.067  1    33.19  ? 272 ASN C C   1 
ATOM   6511 O  O   . ASN C 1 276 ? -64.945 7.847   29.893  1    30.67  ? 272 ASN C O   1 
ATOM   6512 C  CB  . ASN C 1 276 ? -65.573 6.322   32.588  1    42.99  ? 272 ASN C CB  1 
ATOM   6513 C  CG  . ASN C 1 276 ? -65.13  5.287   33.597  1    50.29  ? 272 ASN C CG  1 
ATOM   6514 O  OD1 . ASN C 1 276 ? -64.209 4.505   33.339  1    54.88  ? 272 ASN C OD1 1 
ATOM   6515 N  ND2 . ASN C 1 276 ? -65.79  5.247   34.744  1    51.68  ? 272 ASN C ND2 1 
ATOM   6516 N  N   . LYS C 1 277 ? -65.368 9.428   31.453  1    34.48  ? 273 LYS C N   1 
ATOM   6517 C  CA  . LYS C 1 277 ? -65.939 10.358  30.488  1    35.93  ? 273 LYS C CA  1 
ATOM   6518 C  C   . LYS C 1 277 ? -64.859 11.288  29.957  1    37.32  ? 273 LYS C C   1 
ATOM   6519 O  O   . LYS C 1 277 ? -65.133 12.043  29.024  1    38.25  ? 273 LYS C O   1 
ATOM   6520 C  CB  . LYS C 1 277 ? -67.054 11.236  31.067  1    42.19  ? 273 LYS C CB  1 
ATOM   6521 C  CG  . LYS C 1 277 ? -68.282 10.544  31.658  1    55.1   ? 273 LYS C CG  1 
ATOM   6522 C  CD  . LYS C 1 277 ? -68.915 9.473   30.768  1    68.34  ? 273 LYS C CD  1 
ATOM   6523 C  CE  . LYS C 1 277 ? -70.068 8.717   31.374  1    66.3   ? 273 LYS C CE  1 
ATOM   6524 N  NZ  . LYS C 1 277 ? -70.334 7.471   30.639  1    58.5   ? 273 LYS C NZ  1 
ATOM   6525 N  N   . ARG C 1 278 ? -63.662 11.236  30.578  1    34.63  ? 274 ARG C N   1 
ATOM   6526 C  CA  . ARG C 1 278 ? -62.545 12.115  30.254  1    29.56  ? 274 ARG C CA  1 
ATOM   6527 C  C   . ARG C 1 278 ? -61.975 11.678  28.907  1    27.71  ? 274 ARG C C   1 
ATOM   6528 O  O   . ARG C 1 278 ? -61.812 10.481  28.672  1    28.49  ? 274 ARG C O   1 
ATOM   6529 C  CB  . ARG C 1 278 ? -61.494 12.035  31.367  1    27.89  ? 274 ARG C CB  1 
ATOM   6530 C  CG  . ARG C 1 278 ? -60.551 13.228  31.397  1    28.28  ? 274 ARG C CG  1 
ATOM   6531 C  CD  . ARG C 1 278 ? -59.556 13.204  32.552  1    26.6   ? 274 ARG C CD  1 
ATOM   6532 N  NE  . ARG C 1 278 ? -60.181 13.257  33.875  1    24.31  ? 274 ARG C NE  1 
ATOM   6533 C  CZ  . ARG C 1 278 ? -59.819 12.518  34.909  1    25.06  ? 274 ARG C CZ  1 
ATOM   6534 N  NH1 . ARG C 1 278 ? -58.699 11.816  34.87   1    23.93  ? 274 ARG C NH1 1 
ATOM   6535 N  NH2 . ARG C 1 278 ? -60.55  12.519  36.01   1    25.42  ? 274 ARG C NH2 1 
ATOM   6536 N  N   . ILE C 1 279 ? -61.676 12.648  28.039  1    23.81  ? 275 ILE C N   1 
ATOM   6537 C  CA  . ILE C 1 279 ? -61.269 12.331  26.686  1    26.8   ? 275 ILE C CA  1 
ATOM   6538 C  C   . ILE C 1 279 ? -59.93  11.585  26.704  1    35.92  ? 275 ILE C C   1 
ATOM   6539 O  O   . ILE C 1 279 ? -59.021 11.916  27.47   1    41.94  ? 275 ILE C O   1 
ATOM   6540 C  CB  . ILE C 1 279 ? -61.203 13.62   25.851  1    26.69  ? 275 ILE C CB  1 
ATOM   6541 C  CG1 . ILE C 1 279 ? -61.205 13.339  24.35   1    27.64  ? 275 ILE C CG1 1 
ATOM   6542 C  CG2 . ILE C 1 279 ? -60     14.477  26.239  1    27.31  ? 275 ILE C CG2 1 
ATOM   6543 C  CD1 . ILE C 1 279 ? -61.174 14.611  23.522  1    26.69  ? 275 ILE C CD1 1 
ATOM   6544 N  N   . SER C 1 280 ? -59.803 10.552  25.861  1    39.46  ? 276 SER C N   1 
ATOM   6545 C  CA  . SER C 1 280 ? -58.521 9.89    25.643  1    37.76  ? 276 SER C CA  1 
ATOM   6546 C  C   . SER C 1 280 ? -57.643 10.785  24.783  1    38.21  ? 276 SER C C   1 
ATOM   6547 O  O   . SER C 1 280 ? -58.157 11.643  24.062  1    35.45  ? 276 SER C O   1 
ATOM   6548 C  CB  . SER C 1 280 ? -58.721 8.582   24.943  1    46.2   ? 276 SER C CB  1 
ATOM   6549 O  OG  . SER C 1 280 ? -59.344 8.773   23.674  1    46.49  ? 276 SER C OG  1 
ATOM   6550 N  N   . ALA C 1 281 ? -56.322 10.567  24.851  1    40     ? 277 ALA C N   1 
ATOM   6551 C  CA  . ALA C 1 281 ? -55.385 11.316  24.021  1    33.88  ? 277 ALA C CA  1 
ATOM   6552 C  C   . ALA C 1 281 ? -55.738 11.095  22.554  1    36.69  ? 277 ALA C C   1 
ATOM   6553 O  O   . ALA C 1 281 ? -55.688 12.026  21.76   1    38.63  ? 277 ALA C O   1 
ATOM   6554 C  CB  . ALA C 1 281 ? -53.97  10.886  24.282  1    26.99  ? 277 ALA C CB  1 
ATOM   6555 N  N   . LYS C 1 282 ? -56.089 9.853   22.202  1    33.21  ? 278 LYS C N   1 
ATOM   6556 C  CA  . LYS C 1 282 ? -56.334 9.497   20.819  1    34.46  ? 278 LYS C CA  1 
ATOM   6557 C  C   . LYS C 1 282 ? -57.517 10.307  20.283  1    34.79  ? 278 LYS C C   1 
ATOM   6558 O  O   . LYS C 1 282 ? -57.424 10.934  19.234  1    35.84  ? 278 LYS C O   1 
ATOM   6559 C  CB  . LYS C 1 282 ? -56.488 7.975   20.748  1    39.85  ? 278 LYS C CB  1 
ATOM   6560 C  CG  . LYS C 1 282 ? -56.189 7.366   19.402  1    43.86  ? 278 LYS C CG  1 
ATOM   6561 C  CD  . LYS C 1 282 ? -56.639 5.915   19.242  1    47.05  ? 278 LYS C CD  1 
ATOM   6562 C  CE  . LYS C 1 282 ? -55.809 4.989   20.063  1    45.92  ? 278 LYS C CE  1 
ATOM   6563 N  NZ  . LYS C 1 282 ? -55.976 3.556   19.776  1    43.66  ? 278 LYS C NZ  1 
ATOM   6564 N  N   . ALA C 1 283 ? -58.623 10.33   21.03   1    34.27  ? 279 ALA C N   1 
ATOM   6565 C  CA  . ALA C 1 283 ? -59.787 11.14   20.69   1    31.83  ? 279 ALA C CA  1 
ATOM   6566 C  C   . ALA C 1 283 ? -59.411 12.611  20.547  1    38.22  ? 279 ALA C C   1 
ATOM   6567 O  O   . ALA C 1 283 ? -59.788 13.25   19.562  1    43.8   ? 279 ALA C O   1 
ATOM   6568 C  CB  . ALA C 1 283 ? -60.851 10.982  21.747  1    31.49  ? 279 ALA C CB  1 
ATOM   6569 N  N   . ALA C 1 284 ? -58.68  13.129  21.55   1    38.24  ? 280 ALA C N   1 
ATOM   6570 C  CA  . ALA C 1 284 ? -58.286 14.524  21.625  1    35.5   ? 280 ALA C CA  1 
ATOM   6571 C  C   . ALA C 1 284 ? -57.52  14.949  20.371  1    39.6   ? 280 ALA C C   1 
ATOM   6572 O  O   . ALA C 1 284 ? -57.611 16.103  19.964  1    46.96  ? 280 ALA C O   1 
ATOM   6573 C  CB  . ALA C 1 284 ? -57.491 14.769  22.885  1    34.06  ? 280 ALA C CB  1 
ATOM   6574 N  N   . LEU C 1 285 ? -56.777 14.022  19.751  1    38.7   ? 281 LEU C N   1 
ATOM   6575 C  CA  . LEU C 1 285 ? -56.072 14.298  18.504  1    38.32  ? 281 LEU C CA  1 
ATOM   6576 C  C   . LEU C 1 285 ? -57.049 14.58   17.368  1    38.58  ? 281 LEU C C   1 
ATOM   6577 O  O   . LEU C 1 285 ? -56.685 15.269  16.426  1    41.33  ? 281 LEU C O   1 
ATOM   6578 C  CB  . LEU C 1 285 ? -55.152 13.137  18.136  1    38.01  ? 281 LEU C CB  1 
ATOM   6579 C  CG  . LEU C 1 285 ? -53.877 12.997  18.973  1    39.5   ? 281 LEU C CG  1 
ATOM   6580 C  CD1 . LEU C 1 285 ? -53.149 11.724  18.589  1    38.09  ? 281 LEU C CD1 1 
ATOM   6581 C  CD2 . LEU C 1 285 ? -52.979 14.219  18.798  1    34.62  ? 281 LEU C CD2 1 
ATOM   6582 N  N   . ALA C 1 286 ? -58.267 14.031  17.452  1    36.62  ? 282 ALA C N   1 
ATOM   6583 C  CA  . ALA C 1 286 ? -59.307 14.342  16.475  1    38.5   ? 282 ALA C CA  1 
ATOM   6584 C  C   . ALA C 1 286 ? -59.949 15.714  16.726  1    37.67  ? 282 ALA C C   1 
ATOM   6585 O  O   . ALA C 1 286 ? -60.348 16.368  15.769  1    35.87  ? 282 ALA C O   1 
ATOM   6586 C  CB  . ALA C 1 286 ? -60.345 13.233  16.377  1    33.33  ? 282 ALA C CB  1 
ATOM   6587 N  N   . HIS C 1 287 ? -60.02  16.174  17.989  1    33.99  ? 283 HIS C N   1 
ATOM   6588 C  CA  . HIS C 1 287 ? -60.79  17.366  18.345  1    33.03  ? 283 HIS C CA  1 
ATOM   6589 C  C   . HIS C 1 287 ? -60.644 18.511  17.331  1    35     ? 283 HIS C C   1 
ATOM   6590 O  O   . HIS C 1 287 ? -59.567 18.724  16.773  1    37.74  ? 283 HIS C O   1 
ATOM   6591 C  CB  . HIS C 1 287 ? -60.452 17.855  19.756  1    28.82  ? 283 HIS C CB  1 
ATOM   6592 C  CG  . HIS C 1 287 ? -61.464 18.783  20.327  1    27.87  ? 283 HIS C CG  1 
ATOM   6593 N  ND1 . HIS C 1 287 ? -61.567 20.102  19.921  1    29.72  ? 283 HIS C ND1 1 
ATOM   6594 C  CD2 . HIS C 1 287 ? -62.421 18.603  21.252  1    27.39  ? 283 HIS C CD2 1 
ATOM   6595 C  CE1 . HIS C 1 287 ? -62.563 20.699  20.576  1    27.89  ? 283 HIS C CE1 1 
ATOM   6596 N  NE2 . HIS C 1 287 ? -63.092 19.811  21.397  1    28.06  ? 283 HIS C NE2 1 
ATOM   6597 N  N   . PRO C 1 288 ? -61.725 19.28   17.043  1    34.32  ? 284 PRO C N   1 
ATOM   6598 C  CA  . PRO C 1 288 ? -61.647 20.445  16.153  1    35.09  ? 284 PRO C CA  1 
ATOM   6599 C  C   . PRO C 1 288 ? -60.577 21.482  16.489  1    33.99  ? 284 PRO C C   1 
ATOM   6600 O  O   . PRO C 1 288 ? -60.119 22.194  15.601  1    34.88  ? 284 PRO C O   1 
ATOM   6601 C  CB  . PRO C 1 288 ? -63.076 21.062  16.193  1    32.33  ? 284 PRO C CB  1 
ATOM   6602 C  CG  . PRO C 1 288 ? -63.965 19.897  16.529  1    32.83  ? 284 PRO C CG  1 
ATOM   6603 C  CD  . PRO C 1 288 ? -63.119 19.017  17.459  1    35.48  ? 284 PRO C CD  1 
ATOM   6604 N  N   . PHE C 1 289 ? -60.184 21.595  17.763  1    29.94  ? 285 PHE C N   1 
ATOM   6605 C  CA  . PHE C 1 289 ? -59.204 22.609  18.097  1    32.21  ? 285 PHE C CA  1 
ATOM   6606 C  C   . PHE C 1 289 ? -58.001 22.488  17.155  1    37     ? 285 PHE C C   1 
ATOM   6607 O  O   . PHE C 1 289 ? -57.365 23.489  16.835  1    41.08  ? 285 PHE C O   1 
ATOM   6608 C  CB  . PHE C 1 289 ? -58.893 22.544  19.596  1    33.25  ? 285 PHE C CB  1 
ATOM   6609 C  CG  . PHE C 1 289 ? -57.804 23.479  20.108  1    32.15  ? 285 PHE C CG  1 
ATOM   6610 C  CD1 . PHE C 1 289 ? -57.994 24.851  20.121  1    32.82  ? 285 PHE C CD1 1 
ATOM   6611 C  CD2 . PHE C 1 289 ? -56.603 22.971  20.597  1    33.41  ? 285 PHE C CD2 1 
ATOM   6612 C  CE1 . PHE C 1 289 ? -57.017 25.697  20.612  1    32.96  ? 285 PHE C CE1 1 
ATOM   6613 C  CE2 . PHE C 1 289 ? -55.607 23.808  21.071  1    33.66  ? 285 PHE C CE2 1 
ATOM   6614 C  CZ  . PHE C 1 289 ? -55.827 25.169  21.087  1    40.6   ? 285 PHE C CZ  1 
ATOM   6615 N  N   . PHE C 1 290 ? -57.724 21.271  16.668  1    38.54  ? 286 PHE C N   1 
ATOM   6616 C  CA  . PHE C 1 290 ? -56.464 20.973  15.996  1    42.82  ? 286 PHE C CA  1 
ATOM   6617 C  C   . PHE C 1 290 ? -56.566 21.068  14.475  1    45.36  ? 286 PHE C C   1 
ATOM   6618 O  O   . PHE C 1 290 ? -55.543 20.973  13.8    1    44.74  ? 286 PHE C O   1 
ATOM   6619 C  CB  . PHE C 1 290 ? -55.917 19.613  16.438  1    36.11  ? 286 PHE C CB  1 
ATOM   6620 C  CG  . PHE C 1 290 ? -55.472 19.615  17.889  1    31.57  ? 286 PHE C CG  1 
ATOM   6621 C  CD1 . PHE C 1 290 ? -54.436 20.451  18.311  1    31.17  ? 286 PHE C CD1 1 
ATOM   6622 C  CD2 . PHE C 1 290 ? -56.091 18.789  18.818  1    29.29  ? 286 PHE C CD2 1 
ATOM   6623 C  CE1 . PHE C 1 290 ? -54.024 20.444  19.636  1    30.69  ? 286 PHE C CE1 1 
ATOM   6624 C  CE2 . PHE C 1 290 ? -55.674 18.787  20.146  1    30.82  ? 286 PHE C CE2 1 
ATOM   6625 C  CZ  . PHE C 1 290 ? -54.648 19.615  20.554  1    29.17  ? 286 PHE C CZ  1 
ATOM   6626 N  N   . GLN C 1 291 ? -57.781 21.282  13.953  1    49.72  ? 287 GLN C N   1 
ATOM   6627 C  CA  . GLN C 1 291 ? -58.056 21.318  12.522  1    55.36  ? 287 GLN C CA  1 
ATOM   6628 C  C   . GLN C 1 291 ? -56.99  22.114  11.761  1    46.18  ? 287 GLN C C   1 
ATOM   6629 O  O   . GLN C 1 291 ? -56.665 21.788  10.62   1    44.89  ? 287 GLN C O   1 
ATOM   6630 C  CB  . GLN C 1 291 ? -59.443 21.923  12.254  1    68.7   ? 287 GLN C CB  1 
ATOM   6631 C  CG  . GLN C 1 291 ? -60.342 21.107  11.331  1    78.37  ? 287 GLN C CG  1 
ATOM   6632 C  CD  . GLN C 1 291 ? -60.696 19.758  11.919  1    90.12  ? 287 GLN C CD  1 
ATOM   6633 O  OE1 . GLN C 1 291 ? -59.905 18.803  11.902  1    89.64  ? 287 GLN C OE1 1 
ATOM   6634 N  NE2 . GLN C 1 291 ? -61.911 19.669  12.438  1    91.09  ? 287 GLN C NE2 1 
ATOM   6635 N  N   . ASP C 1 292 ? -56.48  23.185  12.376  1    39.8   ? 288 ASP C N   1 
ATOM   6636 C  CA  . ASP C 1 292 ? -55.669 24.147  11.648  1    40.5   ? 288 ASP C CA  1 
ATOM   6637 C  C   . ASP C 1 292 ? -54.25  24.195  12.21   1    40.38  ? 288 ASP C C   1 
ATOM   6638 O  O   . ASP C 1 292 ? -53.554 25.186  11.997  1    39.66  ? 288 ASP C O   1 
ATOM   6639 C  CB  . ASP C 1 292 ? -56.333 25.52   11.626  1    46.8   ? 288 ASP C CB  1 
ATOM   6640 C  CG  . ASP C 1 292 ? -56.707 26.11   12.985  1    48.46  ? 288 ASP C CG  1 
ATOM   6641 O  OD1 . ASP C 1 292 ? -56.581 25.383  14.005  1    49.13  ? 288 ASP C OD1 1 
ATOM   6642 O  OD2 . ASP C 1 292 ? -57.129 27.289  13.017  1    43.13  ? 288 ASP C OD2 1 
ATOM   6643 N  N   . VAL C 1 293 ? -53.805 23.122  12.884  1    37.65  ? 289 VAL C N   1 
ATOM   6644 C  CA  . VAL C 1 293 ? -52.573 23.191  13.658  1    36.8   ? 289 VAL C CA  1 
ATOM   6645 C  C   . VAL C 1 293 ? -51.377 23.33   12.713  1    42.07  ? 289 VAL C C   1 
ATOM   6646 O  O   . VAL C 1 293 ? -51.341 22.673  11.675  1    47.67  ? 289 VAL C O   1 
ATOM   6647 C  CB  . VAL C 1 293 ? -52.418 22.005  14.631  1    33.86  ? 289 VAL C CB  1 
ATOM   6648 C  CG1 . VAL C 1 293 ? -52.395 20.669  13.902  1    33.28  ? 289 VAL C CG1 1 
ATOM   6649 C  CG2 . VAL C 1 293 ? -51.192 22.151  15.531  1    25.93  ? 289 VAL C CG2 1 
ATOM   6650 N  N   . THR C 1 294 ? -50.419 24.2    13.08   1    42.69  ? 290 THR C N   1 
ATOM   6651 C  CA  . THR C 1 294 ? -49.13  24.306  12.402  1    40.93  ? 290 THR C CA  1 
ATOM   6652 C  C   . THR C 1 294 ? -48.02  23.869  13.365  1    42.64  ? 290 THR C C   1 
ATOM   6653 O  O   . THR C 1 294 ? -48.294 23.376  14.46   1    44.28  ? 290 THR C O   1 
ATOM   6654 C  CB  . THR C 1 294 ? -48.899 25.69   11.769  1    37.71  ? 290 THR C CB  1 
ATOM   6655 O  OG1 . THR C 1 294 ? -48.774 26.727  12.741  1    36.37  ? 290 THR C OG1 1 
ATOM   6656 C  CG2 . THR C 1 294 ? -50.006 26.092  10.809  1    34.64  ? 290 THR C CG2 1 
ATOM   6657 N  N   . LYS C 1 295 ? -46.767 24.021  12.929  1    41.59  ? 291 LYS C N   1 
ATOM   6658 C  CA  . LYS C 1 295 ? -45.606 23.853  13.784  1    39.73  ? 291 LYS C CA  1 
ATOM   6659 C  C   . LYS C 1 295 ? -44.802 25.157  13.828  1    36.81  ? 291 LYS C C   1 
ATOM   6660 O  O   . LYS C 1 295 ? -43.764 25.254  13.187  1    35.08  ? 291 LYS C O   1 
ATOM   6661 C  CB  . LYS C 1 295 ? -44.799 22.656  13.259  1    39.28  ? 291 LYS C CB  1 
ATOM   6662 C  CG  . LYS C 1 295 ? -43.648 22.199  14.165  1    40.13  ? 291 LYS C CG  1 
ATOM   6663 C  CD  . LYS C 1 295 ? -43.497 20.682  14.144  1    45.27  ? 291 LYS C CD  1 
ATOM   6664 C  CE  . LYS C 1 295 ? -42.441 20.073  15.022  1    53.21  ? 291 LYS C CE  1 
ATOM   6665 N  NZ  . LYS C 1 295 ? -41.059 20.209  14.535  1    53.14  ? 291 LYS C NZ  1 
ATOM   6666 N  N   . PRO C 1 296 ? -45.224 26.191  14.594  1    37.58  ? 292 PRO C N   1 
ATOM   6667 C  CA  . PRO C 1 296 ? -44.424 27.418  14.759  1    38.1   ? 292 PRO C CA  1 
ATOM   6668 C  C   . PRO C 1 296 ? -43.092 27.209  15.482  1    41.45  ? 292 PRO C C   1 
ATOM   6669 O  O   . PRO C 1 296 ? -42.939 26.275  16.267  1    46.61  ? 292 PRO C O   1 
ATOM   6670 C  CB  . PRO C 1 296 ? -45.31  28.382  15.57   1    33.58  ? 292 PRO C CB  1 
ATOM   6671 C  CG  . PRO C 1 296 ? -46.662 27.71   15.655  1    36.36  ? 292 PRO C CG  1 
ATOM   6672 C  CD  . PRO C 1 296 ? -46.461 26.22   15.39   1    39.21  ? 292 PRO C CD  1 
ATOM   6673 N  N   . VAL C 1 297 ? -42.144 28.121  15.251  1    42.42  ? 293 VAL C N   1 
ATOM   6674 C  CA  . VAL C 1 297 ? -40.886 28.147  15.984  1    49.27  ? 293 VAL C CA  1 
ATOM   6675 C  C   . VAL C 1 297 ? -41.052 28.963  17.277  1    47.53  ? 293 VAL C C   1 
ATOM   6676 O  O   . VAL C 1 297 ? -41.757 29.956  17.313  1    49.22  ? 293 VAL C O   1 
ATOM   6677 C  CB  . VAL C 1 297 ? -39.776 28.646  15.026  1    43.2   ? 293 VAL C CB  1 
ATOM   6678 C  CG1 . VAL C 1 297 ? -38.628 29.369  15.721  1    43.38  ? 293 VAL C CG1 1 
ATOM   6679 C  CG2 . VAL C 1 297 ? -39.248 27.493  14.171  1    40.28  ? 293 VAL C CG2 1 
ATOM   6680 N  N   . PRO C 1 298 ? -40.451 28.581  18.424  1    52.66  ? 294 PRO C N   1 
ATOM   6681 C  CA  . PRO C 1 298 ? -40.535 29.417  19.63   1    52.94  ? 294 PRO C CA  1 
ATOM   6682 C  C   . PRO C 1 298 ? -39.511 30.547  19.522  1    59.18  ? 294 PRO C C   1 
ATOM   6683 O  O   . PRO C 1 298 ? -38.51  30.427  18.818  1    69.56  ? 294 PRO C O   1 
ATOM   6684 C  CB  . PRO C 1 298 ? -40.177 28.423  20.739  1    49.16  ? 294 PRO C CB  1 
ATOM   6685 C  CG  . PRO C 1 298 ? -39.206 27.457  20.076  1    54.74  ? 294 PRO C CG  1 
ATOM   6686 C  CD  . PRO C 1 298 ? -39.633 27.371  18.61   1    54.86  ? 294 PRO C CD  1 
ATOM   6687 N  N   . HIS C 1 299 ? -39.755 31.65   20.226  1    62.96  ? 295 HIS C N   1 
ATOM   6688 C  CA  . HIS C 1 299 ? -38.761 32.707  20.291  1    70.59  ? 295 HIS C CA  1 
ATOM   6689 C  C   . HIS C 1 299 ? -38.091 32.644  21.668  1    77.06  ? 295 HIS C C   1 
ATOM   6690 O  O   . HIS C 1 299 ? -38.736 32.979  22.668  1    72.24  ? 295 HIS C O   1 
ATOM   6691 C  CB  . HIS C 1 299 ? -39.423 34.041  19.925  1    77.51  ? 295 HIS C CB  1 
ATOM   6692 C  CG  . HIS C 1 299 ? -38.527 35.233  20.003  1    97.57  ? 295 HIS C CG  1 
ATOM   6693 N  ND1 . HIS C 1 299 ? -38.495 36.087  21.089  1    98.56  ? 295 HIS C ND1 1 
ATOM   6694 C  CD2 . HIS C 1 299 ? -37.654 35.727  19.109  1    98.71  ? 295 HIS C CD2 1 
ATOM   6695 C  CE1 . HIS C 1 299 ? -37.624 37.06   20.855  1    98.35  ? 295 HIS C CE1 1 
ATOM   6696 N  NE2 . HIS C 1 299 ? -37.101 36.861  19.658  1    104.59 ? 295 HIS C NE2 1 
ATOM   6697 N  N   . LEU C 1 300 ? -36.812 32.213  21.711  1    75.01  ? 296 LEU C N   1 
ATOM   6698 C  CA  . LEU C 1 300 ? -36.156 31.849  22.969  1    80.73  ? 296 LEU C CA  1 
ATOM   6699 C  C   . LEU C 1 300 ? -34.678 32.297  23.048  1    67.16  ? 296 LEU C C   1 
ATOM   6700 O  O   . LEU C 1 300 ? -34.229 32.998  22.133  1    55.25  ? 296 LEU C O   1 
ATOM   6701 C  CB  . LEU C 1 300 ? -36.305 30.354  23.274  1    79.28  ? 296 LEU C CB  1 
ATOM   6702 C  CG  . LEU C 1 300 ? -35.676 29.394  22.258  1    88.23  ? 296 LEU C CG  1 
ATOM   6703 C  CD1 . LEU C 1 300 ? -34.157 29.208  22.407  1    89.27  ? 296 LEU C CD1 1 
ATOM   6704 C  CD2 . LEU C 1 300 ? -36.397 28.047  22.249  1    73.75  ? 296 LEU C CD2 1 
ATOM   6705 N  N   . GLY D 2 1   ? -64.997 0.716   32.102  1    45.82  ? 171 GLY D N   1 
ATOM   6706 C  CA  . GLY D 2 1   ? -64.613 1.99    31.463  1    44.88  ? 171 GLY D CA  1 
ATOM   6707 C  C   . GLY D 2 1   ? -63.093 2.11    31.334  1    42.3   ? 171 GLY D C   1 
ATOM   6708 O  O   . GLY D 2 1   ? -62.443 1.237   30.766  1    39.63  ? 171 GLY D O   1 
ATOM   6709 N  N   . VAL D 2 2   ? -62.534 3.177   31.911  1    36.75  ? 172 VAL D N   1 
ATOM   6710 C  CA  . VAL D 2 2   ? -61.211 3.62    31.524  1    35.69  ? 172 VAL D CA  1 
ATOM   6711 C  C   . VAL D 2 2   ? -60.157 2.658   32.074  1    38.7   ? 172 VAL D C   1 
ATOM   6712 O  O   . VAL D 2 2   ? -59.027 2.647   31.586  1    39.67  ? 172 VAL D O   1 
ATOM   6713 C  CB  . VAL D 2 2   ? -60.942 5.082   31.924  1    33.74  ? 172 VAL D CB  1 
ATOM   6714 C  CG1 . VAL D 2 2   ? -60.482 5.199   33.373  1    31.19  ? 172 VAL D CG1 1 
ATOM   6715 C  CG2 . VAL D 2 2   ? -59.942 5.751   30.984  1    31.6   ? 172 VAL D CG2 1 
ATOM   6716 N  N   . ASN D 2 3   ? -60.54  1.829   33.053  1    37.56  ? 173 ASN D N   1 
ATOM   6717 C  CA  . ASN D 2 3   ? -59.645 0.822   33.618  1    38.01  ? 173 ASN D CA  1 
ATOM   6718 C  C   . ASN D 2 3   ? -59.42  -0.35   32.655  1    38.67  ? 173 ASN D C   1 
ATOM   6719 O  O   . ASN D 2 3   ? -58.46  -1.103  32.824  1    40.85  ? 173 ASN D O   1 
ATOM   6720 C  CB  . ASN D 2 3   ? -60.104 0.332   34.989  1    38.75  ? 173 ASN D CB  1 
ATOM   6721 C  CG  . ASN D 2 3   ? -60.361 1.463   35.959  1    40.7   ? 173 ASN D CG  1 
ATOM   6722 O  OD1 . ASN D 2 3   ? -59.662 2.489   35.922  1    37.47  ? 173 ASN D OD1 1 
ATOM   6723 N  ND2 . ASN D 2 3   ? -61.376 1.303   36.804  1    37.94  ? 173 ASN D ND2 1 
ATOM   6724 N  N   . GLU D 2 4   ? -60.308 -0.502  31.66   1    40.08  ? 174 GLU D N   1 
ATOM   6725 C  CA  . GLU D 2 4   ? -60.168 -1.501  30.61   1    43.77  ? 174 GLU D CA  1 
ATOM   6726 C  C   . GLU D 2 4   ? -59.636 -0.855  29.332  1    46.27  ? 174 GLU D C   1 
ATOM   6727 O  O   . GLU D 2 4   ? -59.553 -1.512  28.296  1    44.59  ? 174 GLU D O   1 
ATOM   6728 C  CB  . GLU D 2 4   ? -61.502 -2.192  30.334  1    42.25  ? 174 GLU D CB  1 
ATOM   6729 C  CG  . GLU D 2 4   ? -62.042 -2.951  31.544  1    46.44  ? 174 GLU D CG  1 
ATOM   6730 C  CD  . GLU D 2 4   ? -63.456 -3.461  31.366  1    49.9   ? 174 GLU D CD  1 
ATOM   6731 O  OE1 . GLU D 2 4   ? -64.005 -3.244  30.258  1    54.64  ? 174 GLU D OE1 1 
ATOM   6732 O  OE2 . GLU D 2 4   ? -63.996 -4.06   32.323  1    50.93  ? 174 GLU D OE2 1 
ATOM   6733 N  N   . VAL D 2 5   ? -59.288 0.438   29.431  1    46.54  ? 175 VAL D N   1 
ATOM   6734 C  CA  . VAL D 2 5   ? -58.634 1.23    28.393  1    45.98  ? 175 VAL D CA  1 
ATOM   6735 C  C   . VAL D 2 5   ? -59.227 0.943   27.009  1    40.63  ? 175 VAL D C   1 
ATOM   6736 O  O   . VAL D 2 5   ? -58.532 0.446   26.121  1    35.17  ? 175 VAL D O   1 
ATOM   6737 C  CB  . VAL D 2 5   ? -57.088 1.136   28.446  1    41.84  ? 175 VAL D CB  1 
ATOM   6738 C  CG1 . VAL D 2 5   ? -56.536 1.911   29.632  1    34.11  ? 175 VAL D CG1 1 
ATOM   6739 C  CG2 . VAL D 2 5   ? -56.564 -0.291  28.486  1    40     ? 175 VAL D CG2 1 
ATOM   6740 N  N   . PRO D 2 6   ? -60.534 1.224   26.795  1    41.35  ? 176 PRO D N   1 
ATOM   6741 C  CA  . PRO D 2 6   ? -61.203 0.965   25.513  1    39.29  ? 176 PRO D CA  1 
ATOM   6742 C  C   . PRO D 2 6   ? -60.463 1.415   24.254  1    43.28  ? 176 PRO D C   1 
ATOM   6743 O  O   . PRO D 2 6   ? -60.2   0.607   23.366  1    51.17  ? 176 PRO D O   1 
ATOM   6744 C  CB  . PRO D 2 6   ? -62.576 1.644   25.625  1    35.26  ? 176 PRO D CB  1 
ATOM   6745 C  CG  . PRO D 2 6   ? -62.548 2.409   26.934  1    36.95  ? 176 PRO D CG  1 
ATOM   6746 C  CD  . PRO D 2 6   ? -61.457 1.787   27.797  1    43.42  ? 176 PRO D CD  1 
ATOM   6747 N  N   . ASP D 2 7   ? -60.107 2.695   24.196  1    45.14  ? 177 ASP D N   1 
ATOM   6748 C  CA  . ASP D 2 7   ? -59.487 3.244   22.96   1    43.7   ? 177 ASP D CA  1 
ATOM   6749 C  C   . ASP D 2 7   ? -58.029 2.802   22.812  1    41.62  ? 177 ASP D C   1 
ATOM   6750 O  O   . ASP D 2 7   ? -57.368 3.335   21.924  1    44.44  ? 177 ASP D O   1 
ATOM   6751 C  CB  . ASP D 2 7   ? -59.615 4.756   22.914  1    49.58  ? 177 ASP D CB  1 
ATOM   6752 C  CG  . ASP D 2 7   ? -61.011 5.307   22.667  1    57.76  ? 177 ASP D CG  1 
ATOM   6753 O  OD1 . ASP D 2 7   ? -61.887 4.526   22.241  1    68.82  ? 177 ASP D OD1 1 
ATOM   6754 O  OD2 . ASP D 2 7   ? -61.215 6.511   22.92   1    53.28  ? 177 ASP D OD2 1 
ATOM   6755 N  N   . TYR D 2 8   ? -57.554 1.862   23.628  1    37.17  ? 178 TYR D N   1 
ATOM   6756 C  CA  . TYR D 2 8   ? -56.164 1.398   23.578  1    31.83  ? 178 TYR D CA  1 
ATOM   6757 C  C   . TYR D 2 8   ? -56.007 -0.125  23.609  1    37.02  ? 178 TYR D C   1 
ATOM   6758 O  O   . TYR D 2 8   ? -54.956 -0.618  23.208  1    37.66  ? 178 TYR D O   1 
ATOM   6759 C  CB  . TYR D 2 8   ? -55.25  1.986   24.66   1    28.89  ? 178 TYR D CB  1 
ATOM   6760 C  CG  . TYR D 2 8   ? -55.11  3.488   24.491  1    27.21  ? 178 TYR D CG  1 
ATOM   6761 C  CD1 . TYR D 2 8   ? -54.488 4.03    23.369  1    24.69  ? 178 TYR D CD1 1 
ATOM   6762 C  CD2 . TYR D 2 8   ? -55.688 4.357   25.413  1    27.29  ? 178 TYR D CD2 1 
ATOM   6763 C  CE1 . TYR D 2 8   ? -54.38  5.401   23.216  1    28.44  ? 178 TYR D CE1 1 
ATOM   6764 C  CE2 . TYR D 2 8   ? -55.615 5.733   25.246  1    27.78  ? 178 TYR D CE2 1 
ATOM   6765 C  CZ  . TYR D 2 8   ? -54.955 6.257   24.149  1    30.32  ? 178 TYR D CZ  1 
ATOM   6766 O  OH  . TYR D 2 8   ? -54.914 7.619   24.002  1    33.8   ? 178 TYR D OH  1 
ATOM   6767 N  N   . HIS D 2 9   ? -57.026 -0.865  24.076  1    44.78  ? 179 HIS D N   1 
ATOM   6768 C  CA  . HIS D 2 9   ? -56.929 -2.303  24.34   1    45.67  ? 179 HIS D CA  1 
ATOM   6769 C  C   . HIS D 2 9   ? -56.458 -3.101  23.115  1    43.25  ? 179 HIS D C   1 
ATOM   6770 O  O   . HIS D 2 9   ? -55.85  -4.158  23.266  1    42.48  ? 179 HIS D O   1 
ATOM   6771 C  CB  . HIS D 2 9   ? -58.202 -2.858  25.001  1    46.17  ? 179 HIS D CB  1 
ATOM   6772 C  CG  . HIS D 2 9   ? -59.369 -3.092  24.084  1    60.27  ? 179 HIS D CG  1 
ATOM   6773 N  ND1 . HIS D 2 9   ? -60.506 -2.305  24.095  1    68.77  ? 179 HIS D ND1 1 
ATOM   6774 C  CD2 . HIS D 2 9   ? -59.6   -4.045  23.161  1    63.32  ? 179 HIS D CD2 1 
ATOM   6775 C  CE1 . HIS D 2 9   ? -61.37  -2.751  23.187  1    68.83  ? 179 HIS D CE1 1 
ATOM   6776 N  NE2 . HIS D 2 9   ? -60.839 -3.808  22.609  1    68.2   ? 179 HIS D NE2 1 
ATOM   6777 N  N   . GLU D 2 10  ? -56.749 -2.614  21.902  1    40.81  ? 180 GLU D N   1 
ATOM   6778 C  CA  . GLU D 2 10  ? -56.376 -3.334  20.697  1    41.49  ? 180 GLU D CA  1 
ATOM   6779 C  C   . GLU D 2 10  ? -54.941 -3.024  20.283  1    39.18  ? 180 GLU D C   1 
ATOM   6780 O  O   . GLU D 2 10  ? -54.189 -3.951  19.987  1    40.34  ? 180 GLU D O   1 
ATOM   6781 C  CB  . GLU D 2 10  ? -57.336 -3.066  19.546  1    44.63  ? 180 GLU D CB  1 
ATOM   6782 C  CG  . GLU D 2 10  ? -58.719 -3.63   19.845  1    58.83  ? 180 GLU D CG  1 
ATOM   6783 C  CD  . GLU D 2 10  ? -59.396 -4.227  18.633  1    66.17  ? 180 GLU D CD  1 
ATOM   6784 O  OE1 . GLU D 2 10  ? -59.365 -3.544  17.573  1    60.54  ? 180 GLU D OE1 1 
ATOM   6785 O  OE2 . GLU D 2 10  ? -59.95  -5.352  18.771  1    65.61  ? 180 GLU D OE2 1 
ATOM   6786 N  N   . ASP D 2 11  ? -54.583 -1.731  20.237  1    35.51  ? 181 ASP D N   1 
ATOM   6787 C  CA  . ASP D 2 11  ? -53.208 -1.304  20.017  1    32.46  ? 181 ASP D CA  1 
ATOM   6788 C  C   . ASP D 2 11  ? -52.264 -2.031  20.979  1    33.59  ? 181 ASP D C   1 
ATOM   6789 O  O   . ASP D 2 11  ? -51.163 -2.405  20.574  1    34.74  ? 181 ASP D O   1 
ATOM   6790 C  CB  . ASP D 2 11  ? -53.041 0.201   20.148  1    29.3   ? 181 ASP D CB  1 
ATOM   6791 C  CG  . ASP D 2 11  ? -53.728 1.019   19.065  1    30.64  ? 181 ASP D CG  1 
ATOM   6792 O  OD1 . ASP D 2 11  ? -54.355 0.388   18.215  1    30.26  ? 181 ASP D OD1 1 
ATOM   6793 O  OD2 . ASP D 2 11  ? -53.643 2.278   19.082  1    30.88  ? 181 ASP D OD2 1 
ATOM   6794 N  N   . ILE D 2 12  ? -52.713 -2.239  22.232  1    29.21  ? 182 ILE D N   1 
ATOM   6795 C  CA  . ILE D 2 12  ? -51.898 -2.843  23.275  1    31.51  ? 182 ILE D CA  1 
ATOM   6796 C  C   . ILE D 2 12  ? -51.732 -4.335  23.021  1    33.78  ? 182 ILE D C   1 
ATOM   6797 O  O   . ILE D 2 12  ? -50.629 -4.858  23.179  1    35.61  ? 182 ILE D O   1 
ATOM   6798 C  CB  . ILE D 2 12  ? -52.468 -2.602  24.687  1    31.87  ? 182 ILE D CB  1 
ATOM   6799 C  CG1 . ILE D 2 12  ? -52.213 -1.182  25.196  1    28.88  ? 182 ILE D CG1 1 
ATOM   6800 C  CG2 . ILE D 2 12  ? -51.898 -3.624  25.673  1    32.39  ? 182 ILE D CG2 1 
ATOM   6801 C  CD1 . ILE D 2 12  ? -53.075 -0.799  26.389  1    29.28  ? 182 ILE D CD1 1 
ATOM   6802 N  N   . HIS D 2 13  ? -52.838 -5.018  22.703  1    36.29  ? 183 HIS D N   1 
ATOM   6803 C  CA  . HIS D 2 13  ? -52.819 -6.436  22.356  1    32.69  ? 183 HIS D CA  1 
ATOM   6804 C  C   . HIS D 2 13  ? -51.865 -6.656  21.18   1    31.26  ? 183 HIS D C   1 
ATOM   6805 O  O   . HIS D 2 13  ? -50.904 -7.419  21.271  1    32.66  ? 183 HIS D O   1 
ATOM   6806 C  CB  . HIS D 2 13  ? -54.238 -6.947  22.099  1    30.51  ? 183 HIS D CB  1 
ATOM   6807 C  CG  . HIS D 2 13  ? -54.272 -8.372  21.657  1    38.25  ? 183 HIS D CG  1 
ATOM   6808 N  ND1 . HIS D 2 13  ? -54.334 -9.416  22.561  1    39.95  ? 183 HIS D ND1 1 
ATOM   6809 C  CD2 . HIS D 2 13  ? -54.226 -8.933  20.434  1    33.97  ? 183 HIS D CD2 1 
ATOM   6810 C  CE1 . HIS D 2 13  ? -54.334 -10.565 21.906  1    36.59  ? 183 HIS D CE1 1 
ATOM   6811 N  NE2 . HIS D 2 13  ? -54.263 -10.298 20.619  1    36.84  ? 183 HIS D NE2 1 
ATOM   6812 N  N   . THR D 2 14  ? -52.107 -5.936  20.083  1    30.43  ? 184 THR D N   1 
ATOM   6813 C  CA  . THR D 2 14  ? -51.271 -6.054  18.9    1    32.35  ? 184 THR D CA  1 
ATOM   6814 C  C   . THR D 2 14  ? -49.799 -5.916  19.279  1    40.39  ? 184 THR D C   1 
ATOM   6815 O  O   . THR D 2 14  ? -48.952 -6.653  18.769  1    45.58  ? 184 THR D O   1 
ATOM   6816 C  CB  . THR D 2 14  ? -51.657 -5.012  17.858  1    30.19  ? 184 THR D CB  1 
ATOM   6817 O  OG1 . THR D 2 14  ? -52.937 -5.431  17.394  1    32.92  ? 184 THR D OG1 1 
ATOM   6818 C  CG2 . THR D 2 14  ? -50.637 -4.944  16.732  1    28.55  ? 184 THR D CG2 1 
ATOM   6819 N  N   . TYR D 2 15  ? -49.513 -4.944  20.158  1    42.31  ? 185 TYR D N   1 
ATOM   6820 C  CA  . TYR D 2 15  ? -48.149 -4.608  20.513  1    35.47  ? 185 TYR D CA  1 
ATOM   6821 C  C   . TYR D 2 15  ? -47.557 -5.748  21.324  1    34.46  ? 185 TYR D C   1 
ATOM   6822 O  O   . TYR D 2 15  ? -46.426 -6.143  21.065  1    40.97  ? 185 TYR D O   1 
ATOM   6823 C  CB  . TYR D 2 15  ? -48.079 -3.262  21.24   1    36.4   ? 185 TYR D CB  1 
ATOM   6824 C  CG  . TYR D 2 15  ? -46.671 -2.929  21.711  1    39.67  ? 185 TYR D CG  1 
ATOM   6825 C  CD1 . TYR D 2 15  ? -45.656 -2.716  20.779  1    38.69  ? 185 TYR D CD1 1 
ATOM   6826 C  CD2 . TYR D 2 15  ? -46.348 -2.87   23.072  1    36.21  ? 185 TYR D CD2 1 
ATOM   6827 C  CE1 . TYR D 2 15  ? -44.364 -2.419  21.191  1    40.58  ? 185 TYR D CE1 1 
ATOM   6828 C  CE2 . TYR D 2 15  ? -45.055 -2.585  23.493  1    35.74  ? 185 TYR D CE2 1 
ATOM   6829 C  CZ  . TYR D 2 15  ? -44.062 -2.351  22.547  1    39     ? 185 TYR D CZ  1 
ATOM   6830 O  OH  . TYR D 2 15  ? -42.762 -2.064  22.892  1    38.9   ? 185 TYR D OH  1 
ATOM   6831 N  N   . LEU D 2 16  ? -48.313 -6.255  22.307  1    32.37  ? 186 LEU D N   1 
ATOM   6832 C  CA  . LEU D 2 16  ? -47.91  -7.381  23.142  1    29.84  ? 186 LEU D CA  1 
ATOM   6833 C  C   . LEU D 2 16  ? -47.674 -8.635  22.301  1    31.23  ? 186 LEU D C   1 
ATOM   6834 O  O   . LEU D 2 16  ? -46.854 -9.469  22.661  1    29.42  ? 186 LEU D O   1 
ATOM   6835 C  CB  . LEU D 2 16  ? -48.982 -7.647  24.195  1    27.6   ? 186 LEU D CB  1 
ATOM   6836 C  CG  . LEU D 2 16  ? -49.06  -6.616  25.32   1    32.18  ? 186 LEU D CG  1 
ATOM   6837 C  CD1 . LEU D 2 16  ? -50.253 -6.879  26.228  1    34.97  ? 186 LEU D CD1 1 
ATOM   6838 C  CD2 . LEU D 2 16  ? -47.78  -6.63   26.117  1    30.24  ? 186 LEU D CD2 1 
ATOM   6839 N  N   . ARG D 2 17  ? -48.428 -8.791  21.205  1    31.43  ? 187 ARG D N   1 
ATOM   6840 C  CA  . ARG D 2 17  ? -48.235 -9.935  20.326  1    36.31  ? 187 ARG D CA  1 
ATOM   6841 C  C   . ARG D 2 17  ? -46.889 -9.804  19.614  1    40.51  ? 187 ARG D C   1 
ATOM   6842 O  O   . ARG D 2 17  ? -46.149 -10.778 19.461  1    47.76  ? 187 ARG D O   1 
ATOM   6843 C  CB  . ARG D 2 17  ? -49.381 -10.089 19.316  1    31.41  ? 187 ARG D CB  1 
ATOM   6844 C  CG  . ARG D 2 17  ? -50.652 -10.689 19.898  1    26.92  ? 187 ARG D CG  1 
ATOM   6845 C  CD  . ARG D 2 17  ? -50.529 -12.166 20.178  1    26.78  ? 187 ARG D CD  1 
ATOM   6846 N  NE  . ARG D 2 17  ? -50.386 -12.869 18.903  1    26.6   ? 187 ARG D NE  1 
ATOM   6847 C  CZ  . ARG D 2 17  ? -51.407 -13.364 18.207  1    27.02  ? 187 ARG D CZ  1 
ATOM   6848 N  NH1 . ARG D 2 17  ? -52.636 -13.415 18.702  1    26.53  ? 187 ARG D NH1 1 
ATOM   6849 N  NH2 . ARG D 2 17  ? -51.179 -13.819 17.002  1    25.34  ? 187 ARG D NH2 1 
ATOM   6850 N  N   . GLU D 2 18  ? -46.6   -8.583  19.157  1    38.48  ? 188 GLU D N   1 
ATOM   6851 C  CA  . GLU D 2 18  ? -45.33  -8.267  18.543  1    39.36  ? 188 GLU D CA  1 
ATOM   6852 C  C   . GLU D 2 18  ? -44.229 -8.626  19.531  1    39.34  ? 188 GLU D C   1 
ATOM   6853 O  O   . GLU D 2 18  ? -43.303 -9.348  19.191  1    44.25  ? 188 GLU D O   1 
ATOM   6854 C  CB  . GLU D 2 18  ? -45.357 -6.767  18.274  1    47.06  ? 188 GLU D CB  1 
ATOM   6855 C  CG  . GLU D 2 18  ? -44.672 -6.34   16.982  1    56.48  ? 188 GLU D CG  1 
ATOM   6856 C  CD  . GLU D 2 18  ? -45.227 -4.982  16.602  1    60.94  ? 188 GLU D CD  1 
ATOM   6857 O  OE1 . GLU D 2 18  ? -46.347 -4.965  16.012  1    54.7   ? 188 GLU D OE1 1 
ATOM   6858 O  OE2 . GLU D 2 18  ? -44.56  -3.976  16.961  1    54.79  ? 188 GLU D OE2 1 
ATOM   6859 N  N   . MET D 2 19  ? -44.389 -8.176  20.774  1    37.63  ? 189 MET D N   1 
ATOM   6860 C  CA  . MET D 2 19  ? -43.296 -8.169  21.722  1    41.7   ? 189 MET D CA  1 
ATOM   6861 C  C   . MET D 2 19  ? -43.041 -9.552  22.313  1    45.29  ? 189 MET D C   1 
ATOM   6862 O  O   . MET D 2 19  ? -41.9   -9.869  22.644  1    46.83  ? 189 MET D O   1 
ATOM   6863 C  CB  . MET D 2 19  ? -43.594 -7.185  22.852  1    42.9   ? 189 MET D CB  1 
ATOM   6864 C  CG  . MET D 2 19  ? -43.526 -5.76   22.393  1    45.06  ? 189 MET D CG  1 
ATOM   6865 S  SD  . MET D 2 19  ? -41.834 -5.384  21.921  1    49.84  ? 189 MET D SD  1 
ATOM   6866 C  CE  . MET D 2 19  ? -41.098 -5.409  23.581  1    48.73  ? 189 MET D CE  1 
ATOM   6867 N  N   . GLU D 2 20  ? -44.099 -10.357 22.468  1    44.8   ? 190 GLU D N   1 
ATOM   6868 C  CA  . GLU D 2 20  ? -43.944 -11.697 23.012  1    45.07  ? 190 GLU D CA  1 
ATOM   6869 C  C   . GLU D 2 20  ? -43.103 -12.536 22.055  1    40.84  ? 190 GLU D C   1 
ATOM   6870 O  O   . GLU D 2 20  ? -42.406 -13.44  22.498  1    41.51  ? 190 GLU D O   1 
ATOM   6871 C  CB  . GLU D 2 20  ? -45.271 -12.398 23.313  1    47.1   ? 190 GLU D CB  1 
ATOM   6872 C  CG  . GLU D 2 20  ? -46.028 -12.872 22.073  1    39.92  ? 190 GLU D CG  1 
ATOM   6873 C  CD  . GLU D 2 20  ? -47.232 -13.759 22.373  1    42.56  ? 190 GLU D CD  1 
ATOM   6874 O  OE1 . GLU D 2 20  ? -47.374 -14.201 23.543  1    35.07  ? 190 GLU D OE1 1 
ATOM   6875 O  OE2 . GLU D 2 20  ? -48.03  -14.007 21.416  1    39.91  ? 190 GLU D OE2 1 
ATOM   6876 N  N   . VAL D 2 21  ? -43.196 -12.241 20.756  1    36.15  ? 191 VAL D N   1 
ATOM   6877 C  CA  . VAL D 2 21  ? -42.333 -12.864 19.766  1    43.19  ? 191 VAL D CA  1 
ATOM   6878 C  C   . VAL D 2 21  ? -40.879 -12.452 20.002  1    45.03  ? 191 VAL D C   1 
ATOM   6879 O  O   . VAL D 2 21  ? -40.013 -13.307 20.041  1    43.49  ? 191 VAL D O   1 
ATOM   6880 C  CB  . VAL D 2 21  ? -42.752 -12.593 18.305  1    40.81  ? 191 VAL D CB  1 
ATOM   6881 C  CG1 . VAL D 2 21  ? -41.7   -13.102 17.326  1    34.55  ? 191 VAL D CG1 1 
ATOM   6882 C  CG2 . VAL D 2 21  ? -44.113 -13.199 17.966  1    40.05  ? 191 VAL D CG2 1 
ATOM   6883 N  N   . LYS D 2 22  ? -40.612 -11.152 20.134  1    49.43  ? 192 LYS D N   1 
ATOM   6884 C  CA  . LYS D 2 22  ? -39.245 -10.657 20.249  1    56.59  ? 192 LYS D CA  1 
ATOM   6885 C  C   . LYS D 2 22  ? -38.581 -11.041 21.581  1    50.1   ? 192 LYS D C   1 
ATOM   6886 O  O   . LYS D 2 22  ? -37.388 -11.306 21.608  1    56.39  ? 192 LYS D O   1 
ATOM   6887 C  CB  . LYS D 2 22  ? -39.173 -9.166  19.891  1    68.01  ? 192 LYS D CB  1 
ATOM   6888 C  CG  . LYS D 2 22  ? -38.994 -8.896  18.381  1    66.35  ? 192 LYS D CG  1 
ATOM   6889 C  CD  . LYS D 2 22  ? -39.267 -7.489  17.852  1    68.43  ? 192 LYS D CD  1 
ATOM   6890 C  CE  . LYS D 2 22  ? -40.661 -7.306  17.306  1    69.41  ? 192 LYS D CE  1 
ATOM   6891 N  NZ  . LYS D 2 22  ? -41.013 -5.962  16.837  1    71.19  ? 192 LYS D NZ  1 
ATOM   6892 N  N   . CYS D 2 23  ? -39.328 -11.089 22.686  1    42.46  ? 193 CYS D N   1 
ATOM   6893 C  CA  . CYS D 2 23  ? -38.769 -11.542 23.955  1    40.39  ? 193 CYS D CA  1 
ATOM   6894 C  C   . CYS D 2 23  ? -38.701 -13.065 24.104  1    42     ? 193 CYS D C   1 
ATOM   6895 O  O   . CYS D 2 23  ? -38.406 -13.521 25.195  1    46.67  ? 193 CYS D O   1 
ATOM   6896 C  CB  . CYS D 2 23  ? -39.605 -11.102 25.156  1    39.97  ? 193 CYS D CB  1 
ATOM   6897 S  SG  . CYS D 2 23  ? -39.605 -9.307  25.404  1    50.39  ? 193 CYS D SG  1 
ATOM   6898 N  N   . LYS D 2 24  ? -38.98  -13.862 23.062  1    46.9   ? 194 LYS D N   1 
ATOM   6899 C  CA  . LYS D 2 24  ? -39.15  -15.304 23.242  1    45.9   ? 194 LYS D CA  1 
ATOM   6900 C  C   . LYS D 2 24  ? -37.803 -15.924 23.62   1    44.35  ? 194 LYS D C   1 
ATOM   6901 O  O   . LYS D 2 24  ? -36.796 -15.538 23.04   1    45.9   ? 194 LYS D O   1 
ATOM   6902 C  CB  . LYS D 2 24  ? -39.687 -15.978 21.967  1    44.73  ? 194 LYS D CB  1 
ATOM   6903 C  CG  . LYS D 2 24  ? -39.973 -17.472 22.054  1    50.47  ? 194 LYS D CG  1 
ATOM   6904 C  CD  . LYS D 2 24  ? -40.553 -18.2   20.837  1    73.19  ? 194 LYS D CD  1 
ATOM   6905 C  CE  . LYS D 2 24  ? -40.87  -19.692 20.765  1    82.4   ? 194 LYS D CE  1 
ATOM   6906 N  NZ  . LYS D 2 24  ? -41.428 -20.23  19.508  1    71.44  ? 194 LYS D NZ  1 
ATOM   6907 N  N   . PRO D 2 25  ? -37.727 -16.885 24.58   1    42.96  ? 195 PRO D N   1 
ATOM   6908 C  CA  . PRO D 2 25  ? -36.501 -17.663 24.81   1    41.26  ? 195 PRO D CA  1 
ATOM   6909 C  C   . PRO D 2 25  ? -36.156 -18.557 23.624  1    40.46  ? 195 PRO D C   1 
ATOM   6910 O  O   . PRO D 2 25  ? -36.98  -18.728 22.734  1    45.96  ? 195 PRO D O   1 
ATOM   6911 C  CB  . PRO D 2 25  ? -36.795 -18.525 26.042  1    40.02  ? 195 PRO D CB  1 
ATOM   6912 C  CG  . PRO D 2 25  ? -38.037 -17.914 26.655  1    42.7   ? 195 PRO D CG  1 
ATOM   6913 C  CD  . PRO D 2 25  ? -38.804 -17.262 25.512  1    41.34  ? 195 PRO D CD  1 
ATOM   6914 N  N   . LYS D 2 26  ? -34.947 -19.136 23.634  1    38.44  ? 196 LYS D N   1 
ATOM   6915 C  CA  . LYS D 2 26  ? -34.604 -20.229 22.738  1    40.72  ? 196 LYS D CA  1 
ATOM   6916 C  C   . LYS D 2 26  ? -35.398 -21.483 23.111  1    45.49  ? 196 LYS D C   1 
ATOM   6917 O  O   . LYS D 2 26  ? -35.365 -21.937 24.262  1    47.83  ? 196 LYS D O   1 
ATOM   6918 C  CB  . LYS D 2 26  ? -33.114 -20.564 22.825  1    45.91  ? 196 LYS D CB  1 
ATOM   6919 C  CG  . LYS D 2 26  ? -32.204 -20.2   21.666  1    52.37  ? 196 LYS D CG  1 
ATOM   6920 C  CD  . LYS D 2 26  ? -31.801 -18.746 21.45   1    58.9   ? 196 LYS D CD  1 
ATOM   6921 C  CE  . LYS D 2 26  ? -30.634 -18.704 20.489  1    66.99  ? 196 LYS D CE  1 
ATOM   6922 N  NZ  . LYS D 2 26  ? -29.406 -19.229 21.107  1    70.87  ? 196 LYS D NZ  1 
ATOM   6923 N  N   . VAL D 2 27  ? -36.086 -22.052 22.114  1    45.37  ? 197 VAL D N   1 
ATOM   6924 C  CA  . VAL D 2 27  ? -36.917 -23.226 22.309  1    46.98  ? 197 VAL D CA  1 
ATOM   6925 C  C   . VAL D 2 27  ? -36.067 -24.373 22.842  1    43.6   ? 197 VAL D C   1 
ATOM   6926 O  O   . VAL D 2 27  ? -36.544 -25.151 23.67   1    44.76  ? 197 VAL D O   1 
ATOM   6927 C  CB  . VAL D 2 27  ? -37.682 -23.651 21.04   1    51.86  ? 197 VAL D CB  1 
ATOM   6928 C  CG1 . VAL D 2 27  ? -38.276 -25.046 21.174  1    50.63  ? 197 VAL D CG1 1 
ATOM   6929 C  CG2 . VAL D 2 27  ? -38.782 -22.661 20.677  1    54.39  ? 197 VAL D CG2 1 
ATOM   6930 N  N   . GLY D 2 28  ? -34.827 -24.504 22.364  1    35.83  ? 198 GLY D N   1 
ATOM   6931 C  CA  . GLY D 2 28  ? -34.074 -25.67  22.813  1    44.19  ? 198 GLY D CA  1 
ATOM   6932 C  C   . GLY D 2 28  ? -32.837 -25.335 23.651  1    51.05  ? 198 GLY D C   1 
ATOM   6933 O  O   . GLY D 2 28  ? -31.792 -25.958 23.462  1    49.71  ? 198 GLY D O   1 
ATOM   6934 N  N   . TYR D 2 29  ? -32.952 -24.369 24.579  1    43.1   ? 199 TYR D N   1 
ATOM   6935 C  CA  . TYR D 2 29  ? -31.759 -23.84  25.219  1    38.08  ? 199 TYR D CA  1 
ATOM   6936 C  C   . TYR D 2 29  ? -31.188 -24.901 26.153  1    36.52  ? 199 TYR D C   1 
ATOM   6937 O  O   . TYR D 2 29  ? -29.98  -24.988 26.351  1    35.63  ? 199 TYR D O   1 
ATOM   6938 C  CB  . TYR D 2 29  ? -31.959 -22.467 25.879  1    35.74  ? 199 TYR D CB  1 
ATOM   6939 C  CG  . TYR D 2 29  ? -32.717 -22.419 27.202  1    35.34  ? 199 TYR D CG  1 
ATOM   6940 C  CD1 . TYR D 2 29  ? -32.147 -22.89  28.383  1    35.27  ? 199 TYR D CD1 1 
ATOM   6941 C  CD2 . TYR D 2 29  ? -33.974 -21.837 27.29   1    34.4   ? 199 TYR D CD2 1 
ATOM   6942 C  CE1 . TYR D 2 29  ? -32.812 -22.809 29.598  1    32     ? 199 TYR D CE1 1 
ATOM   6943 C  CE2 . TYR D 2 29  ? -34.647 -21.751 28.498  1    30.98  ? 199 TYR D CE2 1 
ATOM   6944 C  CZ  . TYR D 2 29  ? -34.07  -22.243 29.649  1    32.07  ? 199 TYR D CZ  1 
ATOM   6945 O  OH  . TYR D 2 29  ? -34.754 -22.143 30.817  1    36.83  ? 199 TYR D OH  1 
ATOM   6946 N  N   . MET D 2 30  ? -32.068 -25.73  26.709  1    32.77  ? 200 MET D N   1 
ATOM   6947 C  CA  . MET D 2 30  ? -31.653 -26.606 27.784  1    32.76  ? 200 MET D CA  1 
ATOM   6948 C  C   . MET D 2 30  ? -30.713 -27.715 27.275  1    38.37  ? 200 MET D C   1 
ATOM   6949 O  O   . MET D 2 30  ? -29.82  -28.182 27.994  1    37.28  ? 200 MET D O   1 
ATOM   6950 C  CB  . MET D 2 30  ? -32.911 -27.103 28.489  1    31.89  ? 200 MET D CB  1 
ATOM   6951 C  CG  . MET D 2 30  ? -32.614 -27.731 29.816  1    34.96  ? 200 MET D CG  1 
ATOM   6952 S  SD  . MET D 2 30  ? -31.793 -26.509 30.845  1    40.66  ? 200 MET D SD  1 
ATOM   6953 C  CE  . MET D 2 30  ? -33.223 -25.584 31.417  1    39.83  ? 200 MET D CE  1 
ATOM   6954 N  N   . LYS D 2 31  ? -30.911 -28.159 26.023  1    41.94  ? 201 LYS D N   1 
ATOM   6955 C  CA  . LYS D 2 31  ? -29.971 -29.07  25.39   1    38.87  ? 201 LYS D CA  1 
ATOM   6956 C  C   . LYS D 2 31  ? -28.593 -28.414 25.296  1    41.68  ? 201 LYS D C   1 
ATOM   6957 O  O   . LYS D 2 31  ? -27.583 -29.084 25.471  1    41.22  ? 201 LYS D O   1 
ATOM   6958 C  CB  . LYS D 2 31  ? -30.343 -29.433 23.959  1    46.07  ? 201 LYS D CB  1 
ATOM   6959 C  CG  . LYS D 2 31  ? -31.69  -30.114 23.658  1    50.64  ? 201 LYS D CG  1 
ATOM   6960 C  CD  . LYS D 2 31  ? -32.145 -29.866 22.215  1    59.27  ? 201 LYS D CD  1 
ATOM   6961 C  CE  . LYS D 2 31  ? -32.092 -30.929 21.064  1    77.39  ? 201 LYS D CE  1 
ATOM   6962 N  NZ  . LYS D 2 31  ? -33.136 -31.954 21.253  1    89.51  ? 201 LYS D NZ  1 
ATOM   6963 N  N   . LYS D 2 32  ? -28.547 -27.099 25.02   1    40     ? 202 LYS D N   1 
ATOM   6964 C  CA  . LYS D 2 32  ? -27.296 -26.385 24.835  1    40.49  ? 202 LYS D CA  1 
ATOM   6965 C  C   . LYS D 2 32  ? -26.648 -26.022 26.177  1    39.93  ? 202 LYS D C   1 
ATOM   6966 O  O   . LYS D 2 32  ? -25.526 -25.525 26.182  1    40.05  ? 202 LYS D O   1 
ATOM   6967 C  CB  . LYS D 2 32  ? -27.509 -25.155 23.944  1    46.42  ? 202 LYS D CB  1 
ATOM   6968 C  CG  . LYS D 2 32  ? -27.82  -25.37  22.451  1    54.96  ? 202 LYS D CG  1 
ATOM   6969 C  CD  . LYS D 2 32  ? -26.81  -26.158 21.606  1    78.45  ? 202 LYS D CD  1 
ATOM   6970 C  CE  . LYS D 2 32  ? -25.352 -25.726 21.422  1    69.84  ? 202 LYS D CE  1 
ATOM   6971 N  NZ  . LYS D 2 32  ? -24.588 -26.637 20.554  1    51.43  ? 202 LYS D NZ  1 
ATOM   6972 N  N   . GLN D 2 33  ? -27.337 -26.243 27.312  1    39.94  ? 203 GLN D N   1 
ATOM   6973 C  CA  . GLN D 2 33  ? -26.77  -26.029 28.649  1    34.48  ? 203 GLN D CA  1 
ATOM   6974 C  C   . GLN D 2 33  ? -26.158 -27.336 29.159  1    39.08  ? 203 GLN D C   1 
ATOM   6975 O  O   . GLN D 2 33  ? -26.872 -28.308 29.473  1    42.26  ? 203 GLN D O   1 
ATOM   6976 C  CB  . GLN D 2 33  ? -27.804 -25.591 29.681  1    28.94  ? 203 GLN D CB  1 
ATOM   6977 C  CG  . GLN D 2 33  ? -28.336 -24.183 29.485  1    31.45  ? 203 GLN D CG  1 
ATOM   6978 C  CD  . GLN D 2 33  ? -27.407 -23.103 29.994  1    34.76  ? 203 GLN D CD  1 
ATOM   6979 O  OE1 . GLN D 2 33  ? -26.396 -23.361 30.654  1    32.94  ? 203 GLN D OE1 1 
ATOM   6980 N  NE2 . GLN D 2 33  ? -27.749 -21.861 29.683  1    30.51  ? 203 GLN D NE2 1 
ATOM   6981 N  N   . PRO D 2 34  ? -24.809 -27.397 29.241  1    38.9   ? 204 PRO D N   1 
ATOM   6982 C  CA  . PRO D 2 34  ? -24.121 -28.649 29.532  1    36.51  ? 204 PRO D CA  1 
ATOM   6983 C  C   . PRO D 2 34  ? -24.331 -29.129 30.964  1    36.02  ? 204 PRO D C   1 
ATOM   6984 O  O   . PRO D 2 34  ? -24.358 -30.325 31.208  1    45.8   ? 204 PRO D O   1 
ATOM   6985 C  CB  . PRO D 2 34  ? -22.638 -28.38  29.19   1    36.82  ? 204 PRO D CB  1 
ATOM   6986 C  CG  . PRO D 2 34  ? -22.495 -26.871 29.159  1    42.67  ? 204 PRO D CG  1 
ATOM   6987 C  CD  . PRO D 2 34  ? -23.885 -26.272 29.009  1    40.79  ? 204 PRO D CD  1 
ATOM   6988 N  N   . ASP D 2 35  ? -24.522 -28.204 31.899  1    35.22  ? 205 ASP D N   1 
ATOM   6989 C  CA  . ASP D 2 35  ? -24.534 -28.593 33.296  1    34.6   ? 205 ASP D CA  1 
ATOM   6990 C  C   . ASP D 2 35  ? -25.927 -28.53  33.927  1    35.06  ? 205 ASP D C   1 
ATOM   6991 O  O   . ASP D 2 35  ? -26.066 -28.882 35.092  1    37.72  ? 205 ASP D O   1 
ATOM   6992 C  CB  . ASP D 2 35  ? -23.547 -27.758 34.09   1    39.75  ? 205 ASP D CB  1 
ATOM   6993 C  CG  . ASP D 2 35  ? -23.192 -28.338 35.444  1    46.6   ? 205 ASP D CG  1 
ATOM   6994 O  OD1 . ASP D 2 35  ? -22.628 -29.437 35.436  1    60.36  ? 205 ASP D OD1 1 
ATOM   6995 O  OD2 . ASP D 2 35  ? -23.5   -27.709 36.482  1    45.39  ? 205 ASP D OD2 1 
ATOM   6996 N  N   . ILE D 2 36  ? -26.948 -28.046 33.205  1    34.26  ? 206 ILE D N   1 
ATOM   6997 C  CA  . ILE D 2 36  ? -28.273 -27.911 33.796  1    37.21  ? 206 ILE D CA  1 
ATOM   6998 C  C   . ILE D 2 36  ? -29.333 -28.52  32.874  1    39.9   ? 206 ILE D C   1 
ATOM   6999 O  O   . ILE D 2 36  ? -29.09  -28.715 31.665  1    40.32  ? 206 ILE D O   1 
ATOM   7000 C  CB  . ILE D 2 36  ? -28.606 -26.46  34.225  1    46.05  ? 206 ILE D CB  1 
ATOM   7001 C  CG1 . ILE D 2 36  ? -28.503 -25.477 33.087  1    49.66  ? 206 ILE D CG1 1 
ATOM   7002 C  CG2 . ILE D 2 36  ? -27.754 -25.988 35.411  1    48.1   ? 206 ILE D CG2 1 
ATOM   7003 C  CD1 . ILE D 2 36  ? -28.957 -24.085 33.462  1    52.83  ? 206 ILE D CD1 1 
ATOM   7004 N  N   . THR D 2 37  ? -30.506 -28.824 33.479  1    33.51  ? 207 THR D N   1 
ATOM   7005 C  CA  . THR D 2 37  ? -31.57  -29.613 32.862  1    35.06  ? 207 THR D CA  1 
ATOM   7006 C  C   . THR D 2 37  ? -32.944 -29.001 33.128  1    37.44  ? 207 THR D C   1 
ATOM   7007 O  O   . THR D 2 37  ? -33.108 -28.17  34.025  1    35.23  ? 207 THR D O   1 
ATOM   7008 C  CB  . THR D 2 37  ? -31.603 -31.058 33.39   1    31.44  ? 207 THR D CB  1 
ATOM   7009 O  OG1 . THR D 2 37  ? -32.173 -31.012 34.698  1    30.65  ? 207 THR D OG1 1 
ATOM   7010 C  CG2 . THR D 2 37  ? -30.252 -31.746 33.385  1    22.02  ? 207 THR D CG2 1 
ATOM   7011 N  N   . ASN D 2 38  ? -33.951 -29.531 32.409  1    37.24  ? 208 ASN D N   1 
ATOM   7012 C  CA  . ASN D 2 38  ? -35.338 -29.113 32.547  1    35.02  ? 208 ASN D CA  1 
ATOM   7013 C  C   . ASN D 2 38  ? -35.792 -29.332 33.99   1    33.78  ? 208 ASN D C   1 
ATOM   7014 O  O   . ASN D 2 38  ? -36.543 -28.533 34.552  1    31.96  ? 208 ASN D O   1 
ATOM   7015 C  CB  . ASN D 2 38  ? -36.224 -29.839 31.543  1    35.6   ? 208 ASN D CB  1 
ATOM   7016 C  CG  . ASN D 2 38  ? -36.103 -29.34  30.116  1    36.79  ? 208 ASN D CG  1 
ATOM   7017 O  OD1 . ASN D 2 38  ? -35.877 -28.153 29.861  1    40.72  ? 208 ASN D OD1 1 
ATOM   7018 N  ND2 . ASN D 2 38  ? -36.351 -30.22  29.161  1    37.4   ? 208 ASN D ND2 1 
ATOM   7019 N  N   . SER D 2 39  ? -35.281 -30.413 34.586  1    33.5   ? 209 SER D N   1 
ATOM   7020 C  CA  . SER D 2 39  ? -35.683 -30.864 35.906  1    30.91  ? 209 SER D CA  1 
ATOM   7021 C  C   . SER D 2 39  ? -35.208 -29.861 36.948  1    31.36  ? 209 SER D C   1 
ATOM   7022 O  O   . SER D 2 39  ? -35.915 -29.55  37.91   1    32.5   ? 209 SER D O   1 
ATOM   7023 C  CB  . SER D 2 39  ? -35.123 -32.23  36.19   1    28.3   ? 209 SER D CB  1 
ATOM   7024 O  OG  . SER D 2 39  ? -35.448 -32.627 37.512  1    29.94  ? 209 SER D OG  1 
ATOM   7025 N  N   . MET D 2 40  ? -33.967 -29.419 36.77   1    29.82  ? 210 MET D N   1 
ATOM   7026 C  CA  . MET D 2 40  ? -33.392 -28.46  37.694  1    36.11  ? 210 MET D CA  1 
ATOM   7027 C  C   . MET D 2 40  ? -34.186 -27.154 37.617  1    35.6   ? 210 MET D C   1 
ATOM   7028 O  O   . MET D 2 40  ? -34.506 -26.571 38.64   1    30.17  ? 210 MET D O   1 
ATOM   7029 C  CB  . MET D 2 40  ? -31.913 -28.221 37.374  1    33.6   ? 210 MET D CB  1 
ATOM   7030 C  CG  . MET D 2 40  ? -31.039 -29.387 37.693  1    31.05  ? 210 MET D CG  1 
ATOM   7031 S  SD  . MET D 2 40  ? -29.374 -28.976 37.162  1    34.4   ? 210 MET D SD  1 
ATOM   7032 C  CE  . MET D 2 40  ? -28.632 -30.614 37.049  1    28.83  ? 210 MET D CE  1 
ATOM   7033 N  N   . ARG D 2 41  ? -34.522 -26.726 36.395  1    36.22  ? 211 ARG D N   1 
ATOM   7034 C  CA  . ARG D 2 41  ? -35.28  -25.503 36.181  1    36.41  ? 211 ARG D CA  1 
ATOM   7035 C  C   . ARG D 2 41  ? -36.627 -25.587 36.9    1    35.04  ? 211 ARG D C   1 
ATOM   7036 O  O   . ARG D 2 41  ? -37.046 -24.603 37.513  1    30.7   ? 211 ARG D O   1 
ATOM   7037 C  CB  . ARG D 2 41  ? -35.45  -25.258 34.676  1    34.35  ? 211 ARG D CB  1 
ATOM   7038 C  CG  . ARG D 2 41  ? -36.305 -24.047 34.336  1    32.56  ? 211 ARG D CG  1 
ATOM   7039 C  CD  . ARG D 2 41  ? -36.555 -23.977 32.846  1    36     ? 211 ARG D CD  1 
ATOM   7040 N  NE  . ARG D 2 41  ? -37.567 -22.973 32.51   1    33.95  ? 211 ARG D NE  1 
ATOM   7041 C  CZ  . ARG D 2 41  ? -38.854 -23.047 32.819  1    29.87  ? 211 ARG D CZ  1 
ATOM   7042 N  NH1 . ARG D 2 41  ? -39.337 -24.132 33.376  1    27     ? 211 ARG D NH1 1 
ATOM   7043 N  NH2 . ARG D 2 41  ? -39.644 -22.02  32.578  1    29.02  ? 211 ARG D NH2 1 
ATOM   7044 N  N   . ALA D 2 42  ? -37.267 -26.766 36.825  1    30.32  ? 212 ALA D N   1 
ATOM   7045 C  CA  . ALA D 2 42  ? -38.535 -27.045 37.492  1    34.44  ? 212 ALA D CA  1 
ATOM   7046 C  C   . ALA D 2 42  ? -38.451 -26.819 39.011  1    34.77  ? 212 ALA D C   1 
ATOM   7047 O  O   . ALA D 2 42  ? -39.343 -26.186 39.599  1    38.16  ? 212 ALA D O   1 
ATOM   7048 C  CB  . ALA D 2 42  ? -39.017 -28.449 37.161  1    30.09  ? 212 ALA D CB  1 
ATOM   7049 N  N   . ILE D 2 43  ? -37.395 -27.348 39.648  1    28.92  ? 213 ILE D N   1 
ATOM   7050 C  CA  . ILE D 2 43  ? -37.139 -27.046 41.051  1    29.49  ? 213 ILE D CA  1 
ATOM   7051 C  C   . ILE D 2 43  ? -37.075 -25.527 41.271  1    31.89  ? 213 ILE D C   1 
ATOM   7052 O  O   . ILE D 2 43  ? -37.632 -25.002 42.232  1    33.43  ? 213 ILE D O   1 
ATOM   7053 C  CB  . ILE D 2 43  ? -35.859 -27.75  41.528  1    27.02  ? 213 ILE D CB  1 
ATOM   7054 C  CG1 . ILE D 2 43  ? -36.067 -29.26  41.613  1    25.95  ? 213 ILE D CG1 1 
ATOM   7055 C  CG2 . ILE D 2 43  ? -35.373 -27.156 42.851  1    24.63  ? 213 ILE D CG2 1 
ATOM   7056 C  CD1 . ILE D 2 43  ? -34.789 -30.06  41.602  1    25.59  ? 213 ILE D CD1 1 
ATOM   7057 N  N   . LEU D 2 44  ? -36.395 -24.823 40.37   1    30.68  ? 214 LEU D N   1 
ATOM   7058 C  CA  . LEU D 2 44  ? -36.145 -23.405 40.541  1    32.73  ? 214 LEU D CA  1 
ATOM   7059 C  C   . LEU D 2 44  ? -37.461 -22.638 40.458  1    34.64  ? 214 LEU D C   1 
ATOM   7060 O  O   . LEU D 2 44  ? -37.783 -21.858 41.364  1    32.3   ? 214 LEU D O   1 
ATOM   7061 C  CB  . LEU D 2 44  ? -35.115 -22.936 39.519  1    29.13  ? 214 LEU D CB  1 
ATOM   7062 C  CG  . LEU D 2 44  ? -34.948 -21.426 39.407  1    31.32  ? 214 LEU D CG  1 
ATOM   7063 C  CD1 . LEU D 2 44  ? -34.381 -20.871 40.7    1    32.01  ? 214 LEU D CD1 1 
ATOM   7064 C  CD2 . LEU D 2 44  ? -34.037 -21.147 38.229  1    32.32  ? 214 LEU D CD2 1 
ATOM   7065 N  N   . VAL D 2 45  ? -38.243 -22.928 39.409  1    30.6   ? 215 VAL D N   1 
ATOM   7066 C  CA  . VAL D 2 45  ? -39.514 -22.247 39.244  1    33.54  ? 215 VAL D CA  1 
ATOM   7067 C  C   . VAL D 2 45  ? -40.414 -22.536 40.453  1    32.69  ? 215 VAL D C   1 
ATOM   7068 O  O   . VAL D 2 45  ? -41.021 -21.624 41.019  1    29.35  ? 215 VAL D O   1 
ATOM   7069 C  CB  . VAL D 2 45  ? -40.161 -22.557 37.881  1    33.07  ? 215 VAL D CB  1 
ATOM   7070 C  CG1 . VAL D 2 45  ? -41.474 -21.801 37.685  1    31.97  ? 215 VAL D CG1 1 
ATOM   7071 C  CG2 . VAL D 2 45  ? -39.206 -22.2   36.748  1    29.88  ? 215 VAL D CG2 1 
ATOM   7072 N  N   . ASP D 2 46  ? -40.432 -23.8   40.893  1    33.53  ? 216 ASP D N   1 
ATOM   7073 C  CA  . ASP D 2 46  ? -41.259 -24.202 42.018  1    32.77  ? 216 ASP D CA  1 
ATOM   7074 C  C   . ASP D 2 46  ? -40.861 -23.419 43.264  1    34.32  ? 216 ASP D C   1 
ATOM   7075 O  O   . ASP D 2 46  ? -41.719 -23.07  44.077  1    36.71  ? 216 ASP D O   1 
ATOM   7076 C  CB  . ASP D 2 46  ? -41.166 -25.693 42.287  1    33     ? 216 ASP D CB  1 
ATOM   7077 C  CG  . ASP D 2 46  ? -42.128 -26.189 43.36   1    35.52  ? 216 ASP D CG  1 
ATOM   7078 O  OD1 . ASP D 2 46  ? -43.283 -26.521 43.003  1    30.39  ? 216 ASP D OD1 1 
ATOM   7079 O  OD2 . ASP D 2 46  ? -41.733 -26.181 44.561  1    35.64  ? 216 ASP D OD2 1 
ATOM   7080 N  N   . TRP D 2 47  ? -39.551 -23.162 43.409  1    37.49  ? 217 TRP D N   1 
ATOM   7081 C  CA  . TRP D 2 47  ? -39.038 -22.406 44.54   1    36.2   ? 217 TRP D CA  1 
ATOM   7082 C  C   . TRP D 2 47  ? -39.472 -20.942 44.464  1    35.71  ? 217 TRP D C   1 
ATOM   7083 O  O   . TRP D 2 47  ? -39.808 -20.348 45.486  1    37.87  ? 217 TRP D O   1 
ATOM   7084 C  CB  . TRP D 2 47  ? -37.518 -22.552 44.678  1    31.73  ? 217 TRP D CB  1 
ATOM   7085 C  CG  . TRP D 2 47  ? -36.913 -21.666 45.742  1    33.06  ? 217 TRP D CG  1 
ATOM   7086 C  CD1 . TRP D 2 47  ? -37.051 -21.8   47.095  1    29.63  ? 217 TRP D CD1 1 
ATOM   7087 C  CD2 . TRP D 2 47  ? -36.044 -20.53  45.533  1    32.34  ? 217 TRP D CD2 1 
ATOM   7088 N  NE1 . TRP D 2 47  ? -36.348 -20.819 47.74   1    35.32  ? 217 TRP D NE1 1 
ATOM   7089 C  CE2 . TRP D 2 47  ? -35.719 -20.027 46.811  1    35.34  ? 217 TRP D CE2 1 
ATOM   7090 C  CE3 . TRP D 2 47  ? -35.521 -19.893 44.402  1    36.71  ? 217 TRP D CE3 1 
ATOM   7091 C  CZ2 . TRP D 2 47  ? -34.905 -18.905 46.987  1    38.24  ? 217 TRP D CZ2 1 
ATOM   7092 C  CZ3 . TRP D 2 47  ? -34.704 -18.79  44.576  1    40.71  ? 217 TRP D CZ3 1 
ATOM   7093 C  CH2 . TRP D 2 47  ? -34.403 -18.305 45.852  1    37.3   ? 217 TRP D CH2 1 
ATOM   7094 N  N   . LEU D 2 48  ? -39.475 -20.375 43.25   1    34.14  ? 218 LEU D N   1 
ATOM   7095 C  CA  . LEU D 2 48  ? -39.938 -19.01  43.053  1    31.73  ? 218 LEU D CA  1 
ATOM   7096 C  C   . LEU D 2 48  ? -41.427 -18.858 43.399  1    35.58  ? 218 LEU D C   1 
ATOM   7097 O  O   . LEU D 2 48  ? -41.844 -17.858 43.978  1    34.49  ? 218 LEU D O   1 
ATOM   7098 C  CB  . LEU D 2 48  ? -39.591 -18.599 41.629  1    29.69  ? 218 LEU D CB  1 
ATOM   7099 C  CG  . LEU D 2 48  ? -38.11  -18.267 41.393  1    32.05  ? 218 LEU D CG  1 
ATOM   7100 C  CD1 . LEU D 2 48  ? -37.882 -17.702 39.986  1    31.26  ? 218 LEU D CD1 1 
ATOM   7101 C  CD2 . LEU D 2 48  ? -37.51  -17.318 42.439  1    26.64  ? 218 LEU D CD2 1 
ATOM   7102 N  N   . VAL D 2 49  ? -42.249 -19.859 43.074  1    33.41  ? 219 VAL D N   1 
ATOM   7103 C  CA  . VAL D 2 49  ? -43.636 -19.813 43.499  1    35.89  ? 219 VAL D CA  1 
ATOM   7104 C  C   . VAL D 2 49  ? -43.714 -19.684 45.028  1    36.09  ? 219 VAL D C   1 
ATOM   7105 O  O   . VAL D 2 49  ? -44.426 -18.824 45.543  1    30.96  ? 219 VAL D O   1 
ATOM   7106 C  CB  . VAL D 2 49  ? -44.362 -21.073 42.98   1    39.01  ? 219 VAL D CB  1 
ATOM   7107 C  CG1 . VAL D 2 49  ? -45.763 -21.235 43.585  1    34.04  ? 219 VAL D CG1 1 
ATOM   7108 C  CG2 . VAL D 2 49  ? -44.394 -21.097 41.454  1    35.6   ? 219 VAL D CG2 1 
ATOM   7109 N  N   . GLU D 2 50  ? -42.977 -20.547 45.749  1    37.54  ? 220 GLU D N   1 
ATOM   7110 C  CA  . GLU D 2 50  ? -42.965 -20.533 47.205  1    39.69  ? 220 GLU D CA  1 
ATOM   7111 C  C   . GLU D 2 50  ? -42.618 -19.136 47.696  1    36.7   ? 220 GLU D C   1 
ATOM   7112 O  O   . GLU D 2 50  ? -43.309 -18.601 48.561  1    38.39  ? 220 GLU D O   1 
ATOM   7113 C  CB  . GLU D 2 50  ? -41.948 -21.495 47.825  1    48.57  ? 220 GLU D CB  1 
ATOM   7114 C  CG  . GLU D 2 50  ? -42.463 -22.921 48.011  1    58.72  ? 220 GLU D CG  1 
ATOM   7115 C  CD  . GLU D 2 50  ? -41.505 -23.898 48.682  1    65.97  ? 220 GLU D CD  1 
ATOM   7116 O  OE1 . GLU D 2 50  ? -41.957 -24.979 49.142  1    71.3   ? 220 GLU D OE1 1 
ATOM   7117 O  OE2 . GLU D 2 50  ? -40.299 -23.586 48.737  1    62.63  ? 220 GLU D OE2 1 
ATOM   7118 N  N   . VAL D 2 51  ? -41.539 -18.579 47.132  1    31.42  ? 221 VAL D N   1 
ATOM   7119 C  CA  . VAL D 2 51  ? -41.078 -17.229 47.436  1    34.9   ? 221 VAL D CA  1 
ATOM   7120 C  C   . VAL D 2 51  ? -42.181 -16.196 47.182  1    35.37  ? 221 VAL D C   1 
ATOM   7121 O  O   . VAL D 2 51  ? -42.448 -15.349 48.037  1    33.03  ? 221 VAL D O   1 
ATOM   7122 C  CB  . VAL D 2 51  ? -39.796 -16.905 46.645  1    33.94  ? 221 VAL D CB  1 
ATOM   7123 C  CG1 . VAL D 2 51  ? -39.507 -15.41  46.568  1    30.6   ? 221 VAL D CG1 1 
ATOM   7124 C  CG2 . VAL D 2 51  ? -38.597 -17.683 47.176  1    29.56  ? 221 VAL D CG2 1 
ATOM   7125 N  N   . GLY D 2 52  ? -42.824 -16.281 46.01   1    34.02  ? 222 GLY D N   1 
ATOM   7126 C  CA  . GLY D 2 52  ? -43.933 -15.401 45.676  1    38.15  ? 222 GLY D CA  1 
ATOM   7127 C  C   . GLY D 2 52  ? -45.067 -15.484 46.701  1    40.22  ? 222 GLY D C   1 
ATOM   7128 O  O   . GLY D 2 52  ? -45.755 -14.492 46.943  1    39.04  ? 222 GLY D O   1 
ATOM   7129 N  N   . GLU D 2 53  ? -45.246 -16.675 47.289  1    44.08  ? 223 GLU D N   1 
ATOM   7130 C  CA  . GLU D 2 53  ? -46.333 -16.964 48.222  1    44.91  ? 223 GLU D CA  1 
ATOM   7131 C  C   . GLU D 2 53  ? -45.989 -16.386 49.592  1    37.7   ? 223 GLU D C   1 
ATOM   7132 O  O   . GLU D 2 53  ? -46.828 -15.728 50.204  1    37.44  ? 223 GLU D O   1 
ATOM   7133 C  CB  . GLU D 2 53  ? -46.582 -18.473 48.26   1    47.16  ? 223 GLU D CB  1 
ATOM   7134 C  CG  . GLU D 2 53  ? -48.012 -18.863 48.606  1    64.51  ? 223 GLU D CG  1 
ATOM   7135 C  CD  . GLU D 2 53  ? -49.116 -18.223 47.772  1    79.1   ? 223 GLU D CD  1 
ATOM   7136 O  OE1 . GLU D 2 53  ? -48.809 -17.493 46.78   1    69.51  ? 223 GLU D OE1 1 
ATOM   7137 O  OE2 . GLU D 2 53  ? -50.302 -18.466 48.133  1    80.42  ? 223 GLU D OE2 1 
ATOM   7138 N  N   . GLU D 2 54  ? -44.728 -16.596 50.013  1    35.54  ? 224 GLU D N   1 
ATOM   7139 C  CA  . GLU D 2 54  ? -44.158 -16.137 51.273  1    32.44  ? 224 GLU D CA  1 
ATOM   7140 C  C   . GLU D 2 54  ? -44.084 -14.608 51.344  1    31.59  ? 224 GLU D C   1 
ATOM   7141 O  O   . GLU D 2 54  ? -44.214 -14.046 52.417  1    35.79  ? 224 GLU D O   1 
ATOM   7142 C  CB  . GLU D 2 54  ? -42.79  -16.798 51.452  1    36.34  ? 224 GLU D CB  1 
ATOM   7143 C  CG  . GLU D 2 54  ? -41.952 -16.286 52.621  1    39.1   ? 224 GLU D CG  1 
ATOM   7144 C  CD  . GLU D 2 54  ? -42.496 -16.642 53.989  1    58.35  ? 224 GLU D CD  1 
ATOM   7145 O  OE1 . GLU D 2 54  ? -43.419 -17.506 54.055  1    68.52  ? 224 GLU D OE1 1 
ATOM   7146 O  OE2 . GLU D 2 54  ? -42.014 -16.051 54.999  1    66.68  ? 224 GLU D OE2 1 
ATOM   7147 N  N   . TYR D 2 55  ? -43.856 -13.928 50.22   1    33.18  ? 225 TYR D N   1 
ATOM   7148 C  CA  . TYR D 2 55  ? -43.662 -12.483 50.213  1    36.73  ? 225 TYR D CA  1 
ATOM   7149 C  C   . TYR D 2 55  ? -44.883 -11.771 49.628  1    39.21  ? 225 TYR D C   1 
ATOM   7150 O  O   . TYR D 2 55  ? -44.826 -10.576 49.354  1    36.51  ? 225 TYR D O   1 
ATOM   7151 C  CB  . TYR D 2 55  ? -42.35  -12.128 49.491  1    42.59  ? 225 TYR D CB  1 
ATOM   7152 C  CG  . TYR D 2 55  ? -41.139 -12.378 50.371  1    45.2   ? 225 TYR D CG  1 
ATOM   7153 C  CD1 . TYR D 2 55  ? -40.544 -13.635 50.425  1    44.87  ? 225 TYR D CD1 1 
ATOM   7154 C  CD2 . TYR D 2 55  ? -40.674 -11.392 51.241  1    47.27  ? 225 TYR D CD2 1 
ATOM   7155 C  CE1 . TYR D 2 55  ? -39.484 -13.884 51.286  1    41.95  ? 225 TYR D CE1 1 
ATOM   7156 C  CE2 . TYR D 2 55  ? -39.632 -11.646 52.122  1    40.9   ? 225 TYR D CE2 1 
ATOM   7157 C  CZ  . TYR D 2 55  ? -39.026 -12.889 52.13   1    37.61  ? 225 TYR D CZ  1 
ATOM   7158 O  OH  . TYR D 2 55  ? -37.971 -13.121 52.953  1    38.39  ? 225 TYR D OH  1 
ATOM   7159 N  N   . LYS D 2 56  ? -45.965 -12.539 49.427  1    45.97  ? 226 LYS D N   1 
ATOM   7160 C  CA  . LYS D 2 56  ? -47.235 -12.065 48.892  1    40.72  ? 226 LYS D CA  1 
ATOM   7161 C  C   . LYS D 2 56  ? -47.006 -11.188 47.655  1    36.28  ? 226 LYS D C   1 
ATOM   7162 O  O   . LYS D 2 56  ? -47.528 -10.081 47.574  1    35.82  ? 226 LYS D O   1 
ATOM   7163 C  CB  . LYS D 2 56  ? -48.063 -11.501 50.055  1    38.55  ? 226 LYS D CB  1 
ATOM   7164 C  CG  . LYS D 2 56  ? -48.421 -12.594 51.044  1    43.91  ? 226 LYS D CG  1 
ATOM   7165 C  CD  . LYS D 2 56  ? -49.164 -12.167 52.299  1    59.59  ? 226 LYS D CD  1 
ATOM   7166 C  CE  . LYS D 2 56  ? -48.275 -11.441 53.285  1    70.78  ? 226 LYS D CE  1 
ATOM   7167 N  NZ  . LYS D 2 56  ? -49.009 -11.003 54.483  1    59.79  ? 226 LYS D NZ  1 
ATOM   7168 N  N   . LEU D 2 57  ? -46.226 -11.714 46.703  1    32.69  ? 227 LEU D N   1 
ATOM   7169 C  CA  . LEU D 2 57  ? -45.919 -11.027 45.464  1    35.06  ? 227 LEU D CA  1 
ATOM   7170 C  C   . LEU D 2 57  ? -47.049 -11.24  44.465  1    38.45  ? 227 LEU D C   1 
ATOM   7171 O  O   . LEU D 2 57  ? -47.852 -12.162 44.625  1    43.13  ? 227 LEU D O   1 
ATOM   7172 C  CB  . LEU D 2 57  ? -44.613 -11.584 44.909  1    31.33  ? 227 LEU D CB  1 
ATOM   7173 C  CG  . LEU D 2 57  ? -43.401 -11.476 45.838  1    32.12  ? 227 LEU D CG  1 
ATOM   7174 C  CD1 . LEU D 2 57  ? -42.15  -11.896 45.079  1    25.21  ? 227 LEU D CD1 1 
ATOM   7175 C  CD2 . LEU D 2 57  ? -43.258 -10.088 46.48   1    26.85  ? 227 LEU D CD2 1 
ATOM   7176 N  N   . GLN D 2 58  ? -47.088 -10.382 43.435  1    37.26  ? 228 GLN D N   1 
ATOM   7177 C  CA  . GLN D 2 58  ? -48.047 -10.511 42.345  1    36.33  ? 228 GLN D CA  1 
ATOM   7178 C  C   . GLN D 2 58  ? -47.685 -11.73  41.511  1    37.3   ? 228 GLN D C   1 
ATOM   7179 O  O   . GLN D 2 58  ? -46.503 -12.022 41.324  1    35.42  ? 228 GLN D O   1 
ATOM   7180 C  CB  . GLN D 2 58  ? -47.961 -9.315  41.401  1    35.64  ? 228 GLN D CB  1 
ATOM   7181 C  CG  . GLN D 2 58  ? -48.434 -8.025  42.046  1    38.7   ? 228 GLN D CG  1 
ATOM   7182 C  CD  . GLN D 2 58  ? -49.876 -8.155  42.477  1    40.32  ? 228 GLN D CD  1 
ATOM   7183 O  OE1 . GLN D 2 58  ? -50.771 -8.358  41.658  1    45.92  ? 228 GLN D OE1 1 
ATOM   7184 N  NE2 . GLN D 2 58  ? -50.115 -8.08   43.773  1    39.87  ? 228 GLN D NE2 1 
ATOM   7185 N  N   . ASN D 2 59  ? -48.711 -12.406 40.987  1    38.3   ? 229 ASN D N   1 
ATOM   7186 C  CA  . ASN D 2 59  ? -48.472 -13.471 40.035  1    39.7   ? 229 ASN D CA  1 
ATOM   7187 C  C   . ASN D 2 59  ? -47.626 -12.954 38.874  1    36.83  ? 229 ASN D C   1 
ATOM   7188 O  O   . ASN D 2 59  ? -46.769 -13.686 38.37   1    34.68  ? 229 ASN D O   1 
ATOM   7189 C  CB  . ASN D 2 59  ? -49.768 -14.127 39.591  1    46.36  ? 229 ASN D CB  1 
ATOM   7190 C  CG  . ASN D 2 59  ? -50.384 -14.899 40.731  1    53.58  ? 229 ASN D CG  1 
ATOM   7191 O  OD1 . ASN D 2 59  ? -49.722 -15.752 41.332  1    54.59  ? 229 ASN D OD1 1 
ATOM   7192 N  ND2 . ASN D 2 59  ? -51.625 -14.584 41.068  1    52.78  ? 229 ASN D ND2 1 
ATOM   7193 N  N   . GLU D 2 60  ? -47.899 -11.707 38.446  1    34.15  ? 230 GLU D N   1 
ATOM   7194 C  CA  . GLU D 2 60  ? -47.234 -11.124 37.294  1    32.34  ? 230 GLU D CA  1 
ATOM   7195 C  C   . GLU D 2 60  ? -45.72  -11.064 37.527  1    36.96  ? 230 GLU D C   1 
ATOM   7196 O  O   . GLU D 2 60  ? -44.932 -11.237 36.592  1    39.91  ? 230 GLU D O   1 
ATOM   7197 C  CB  . GLU D 2 60  ? -47.84  -9.778  36.93   1    29.1   ? 230 GLU D CB  1 
ATOM   7198 C  CG  . GLU D 2 60  ? -46.972 -9.006  35.938  1    32.42  ? 230 GLU D CG  1 
ATOM   7199 C  CD  . GLU D 2 60  ? -46.976 -9.563  34.532  1    29.42  ? 230 GLU D CD  1 
ATOM   7200 O  OE1 . GLU D 2 60  ? -47.741 -10.482 34.293  1    32.42  ? 230 GLU D OE1 1 
ATOM   7201 O  OE2 . GLU D 2 60  ? -46.248 -9.068  33.682  1    29.2   ? 230 GLU D OE2 1 
ATOM   7202 N  N   . THR D 2 61  ? -45.331 -10.846 38.791  1    34.55  ? 231 THR D N   1 
ATOM   7203 C  CA  . THR D 2 61  ? -43.935 -10.821 39.197  1    31.5   ? 231 THR D CA  1 
ATOM   7204 C  C   . THR D 2 61  ? -43.295 -12.179 38.923  1    34.63  ? 231 THR D C   1 
ATOM   7205 O  O   . THR D 2 61  ? -42.178 -12.219 38.411  1    40.81  ? 231 THR D O   1 
ATOM   7206 C  CB  . THR D 2 61  ? -43.819 -10.412 40.665  1    30.89  ? 231 THR D CB  1 
ATOM   7207 O  OG1 . THR D 2 61  ? -44.381 -9.107  40.732  1    32.67  ? 231 THR D OG1 1 
ATOM   7208 C  CG2 . THR D 2 61  ? -42.378 -10.249 41.116  1    29.73  ? 231 THR D CG2 1 
ATOM   7209 N  N   . LEU D 2 62  ? -44.013 -13.264 39.259  1    31.44  ? 232 LEU D N   1 
ATOM   7210 C  CA  . LEU D 2 62  ? -43.557 -14.625 39.032  1    29.4   ? 232 LEU D CA  1 
ATOM   7211 C  C   . LEU D 2 62  ? -43.297 -14.869 37.55   1    32.7   ? 232 LEU D C   1 
ATOM   7212 O  O   . LEU D 2 62  ? -42.309 -15.497 37.188  1    34.04  ? 232 LEU D O   1 
ATOM   7213 C  CB  . LEU D 2 62  ? -44.578 -15.634 39.551  1    27.66  ? 232 LEU D CB  1 
ATOM   7214 C  CG  . LEU D 2 62  ? -44.198 -17.11  39.385  1    25.12  ? 232 LEU D CG  1 
ATOM   7215 C  CD1 . LEU D 2 62  ? -42.998 -17.436 40.268  1    27.91  ? 232 LEU D CD1 1 
ATOM   7216 C  CD2 . LEU D 2 62  ? -45.338 -18.022 39.747  1    23.02  ? 232 LEU D CD2 1 
ATOM   7217 N  N   . HIS D 2 63  ? -44.239 -14.446 36.708  1    37.21  ? 233 HIS D N   1 
ATOM   7218 C  CA  . HIS D 2 63  ? -44.172 -14.754 35.286  1    37.66  ? 233 HIS D CA  1 
ATOM   7219 C  C   . HIS D 2 63  ? -42.979 -14.026 34.688  1    38.91  ? 233 HIS D C   1 
ATOM   7220 O  O   . HIS D 2 63  ? -42.24  -14.617 33.9    1    39.69  ? 233 HIS D O   1 
ATOM   7221 C  CB  . HIS D 2 63  ? -45.468 -14.369 34.555  1    34.36  ? 233 HIS D CB  1 
ATOM   7222 C  CG  . HIS D 2 63  ? -46.571 -15.353 34.681  1    35.02  ? 233 HIS D CG  1 
ATOM   7223 N  ND1 . HIS D 2 63  ? -47.232 -15.585 35.872  1    38.69  ? 233 HIS D ND1 1 
ATOM   7224 C  CD2 . HIS D 2 63  ? -47.113 -16.18  33.778  1    33.03  ? 233 HIS D CD2 1 
ATOM   7225 C  CE1 . HIS D 2 63  ? -48.164 -16.513 35.682  1    36.6   ? 233 HIS D CE1 1 
ATOM   7226 N  NE2 . HIS D 2 63  ? -48.099 -16.886 34.423  1    35.97  ? 233 HIS D NE2 1 
ATOM   7227 N  N   . LEU D 2 64  ? -42.81  -12.749 35.085  1    35.09  ? 234 LEU D N   1 
ATOM   7228 C  CA  . LEU D 2 64  ? -41.703 -11.941 34.609  1    35.81  ? 234 LEU D CA  1 
ATOM   7229 C  C   . LEU D 2 64  ? -40.365 -12.598 34.977  1    40.26  ? 234 LEU D C   1 
ATOM   7230 O  O   . LEU D 2 64  ? -39.462 -12.719 34.126  1    39.3   ? 234 LEU D O   1 
ATOM   7231 C  CB  . LEU D 2 64  ? -41.831 -10.545 35.208  1    31     ? 234 LEU D CB  1 
ATOM   7232 C  CG  . LEU D 2 64  ? -42.917 -9.643  34.627  1    26.76  ? 234 LEU D CG  1 
ATOM   7233 C  CD1 . LEU D 2 64  ? -42.954 -8.387  35.451  1    29.6   ? 234 LEU D CD1 1 
ATOM   7234 C  CD2 . LEU D 2 64  ? -42.643 -9.295  33.189  1    24.22  ? 234 LEU D CD2 1 
ATOM   7235 N  N   . ALA D 2 65  ? -40.247 -13.03  36.247  1    35.89  ? 235 ALA D N   1 
ATOM   7236 C  CA  . ALA D 2 65  ? -39.003 -13.615 36.72   1    36.94  ? 235 ALA D CA  1 
ATOM   7237 C  C   . ALA D 2 65  ? -38.647 -14.824 35.852  1    35.55  ? 235 ALA D C   1 
ATOM   7238 O  O   . ALA D 2 65  ? -37.498 -14.997 35.45   1    36.92  ? 235 ALA D O   1 
ATOM   7239 C  CB  . ALA D 2 65  ? -39.106 -13.964 38.188  1    35.71  ? 235 ALA D CB  1 
ATOM   7240 N  N   . VAL D 2 66  ? -39.662 -15.618 35.506  1    31.9   ? 236 VAL D N   1 
ATOM   7241 C  CA  . VAL D 2 66  ? -39.413 -16.838 34.771  1    29.57  ? 236 VAL D CA  1 
ATOM   7242 C  C   . VAL D 2 66  ? -39.015 -16.438 33.359  1    31.75  ? 236 VAL D C   1 
ATOM   7243 O  O   . VAL D 2 66  ? -38.121 -17.053 32.783  1    33.3   ? 236 VAL D O   1 
ATOM   7244 C  CB  . VAL D 2 66  ? -40.606 -17.806 34.822  1    26.93  ? 236 VAL D CB  1 
ATOM   7245 C  CG1 . VAL D 2 66  ? -40.435 -18.974 33.87   1    25.95  ? 236 VAL D CG1 1 
ATOM   7246 C  CG2 . VAL D 2 66  ? -40.851 -18.311 36.243  1    25.73  ? 236 VAL D CG2 1 
ATOM   7247 N  N   . ASN D 2 67  ? -39.62  -15.355 32.843  1    30.96  ? 237 ASN D N   1 
ATOM   7248 C  CA  . ASN D 2 67  ? -39.25  -14.848 31.53   1    28.62  ? 237 ASN D CA  1 
ATOM   7249 C  C   . ASN D 2 67  ? -37.752 -14.5   31.529  1    36.85  ? 237 ASN D C   1 
ATOM   7250 O  O   . ASN D 2 67  ? -37.013 -14.918 30.623  1    28.65  ? 237 ASN D O   1 
ATOM   7251 C  CB  . ASN D 2 67  ? -40.164 -13.713 31.086  1    26.76  ? 237 ASN D CB  1 
ATOM   7252 C  CG  . ASN D 2 67  ? -39.717 -13.108 29.77   1    31.22  ? 237 ASN D CG  1 
ATOM   7253 O  OD1 . ASN D 2 67  ? -38.833 -12.242 29.735  1    33.61  ? 237 ASN D OD1 1 
ATOM   7254 N  ND2 . ASN D 2 67  ? -40.285 -13.568 28.662  1    32.76  ? 237 ASN D ND2 1 
ATOM   7255 N  N   . TYR D 2 68  ? -37.308 -13.755 32.572  1    35.79  ? 238 TYR D N   1 
ATOM   7256 C  CA  . TYR D 2 68  ? -35.932 -13.277 32.671  1    34.15  ? 238 TYR D CA  1 
ATOM   7257 C  C   . TYR D 2 68  ? -34.943 -14.439 32.706  1    35.74  ? 238 TYR D C   1 
ATOM   7258 O  O   . TYR D 2 68  ? -33.874 -14.372 32.097  1    34.38  ? 238 TYR D O   1 
ATOM   7259 C  CB  . TYR D 2 68  ? -35.74  -12.362 33.883  1    33.24  ? 238 TYR D CB  1 
ATOM   7260 C  CG  . TYR D 2 68  ? -36.632 -11.132 33.899  1    32.15  ? 238 TYR D CG  1 
ATOM   7261 C  CD1 . TYR D 2 68  ? -37.351 -10.741 32.768  1    31.27  ? 238 TYR D CD1 1 
ATOM   7262 C  CD2 . TYR D 2 68  ? -36.799 -10.405 35.066  1    33.3   ? 238 TYR D CD2 1 
ATOM   7263 C  CE1 . TYR D 2 68  ? -38.182 -9.63   32.779  1    33.82  ? 238 TYR D CE1 1 
ATOM   7264 C  CE2 . TYR D 2 68  ? -37.626 -9.294  35.102  1    34.13  ? 238 TYR D CE2 1 
ATOM   7265 C  CZ  . TYR D 2 68  ? -38.308 -8.912  33.956  1    34.4   ? 238 TYR D CZ  1 
ATOM   7266 O  OH  . TYR D 2 68  ? -39.136 -7.852  33.986  1    36.73  ? 238 TYR D OH  1 
ATOM   7267 N  N   . ILE D 2 69  ? -35.317 -15.504 33.426  1    41.5   ? 239 ILE D N   1 
ATOM   7268 C  CA  . ILE D 2 69  ? -34.487 -16.687 33.605  1    37.76  ? 239 ILE D CA  1 
ATOM   7269 C  C   . ILE D 2 69  ? -34.333 -17.412 32.27   1    40.37  ? 239 ILE D C   1 
ATOM   7270 O  O   . ILE D 2 69  ? -33.224 -17.742 31.855  1    37.14  ? 239 ILE D O   1 
ATOM   7271 C  CB  . ILE D 2 69  ? -35.073 -17.589 34.701  1    35.05  ? 239 ILE D CB  1 
ATOM   7272 C  CG1 . ILE D 2 69  ? -34.961 -16.897 36.083  1    32.95  ? 239 ILE D CG1 1 
ATOM   7273 C  CG2 . ILE D 2 69  ? -34.385 -18.947 34.689  1    29.75  ? 239 ILE D CG2 1 
ATOM   7274 C  CD1 . ILE D 2 69  ? -35.858 -17.493 37.147  1    29.18  ? 239 ILE D CD1 1 
ATOM   7275 N  N   . ASP D 2 70  ? -35.447 -17.612 31.565  1    38.42  ? 240 ASP D N   1 
ATOM   7276 C  CA  . ASP D 2 70  ? -35.353 -18.354 30.32   1    37.77  ? 240 ASP D CA  1 
ATOM   7277 C  C   . ASP D 2 70  ? -34.516 -17.561 29.333  1    33.62  ? 240 ASP D C   1 
ATOM   7278 O  O   . ASP D 2 70  ? -33.736 -18.145 28.594  1    36.77  ? 240 ASP D O   1 
ATOM   7279 C  CB  . ASP D 2 70  ? -36.708 -18.797 29.784  1    40.22  ? 240 ASP D CB  1 
ATOM   7280 C  CG  . ASP D 2 70  ? -37.46  -19.773 30.681  1    41.15  ? 240 ASP D CG  1 
ATOM   7281 O  OD1 . ASP D 2 70  ? -36.784 -20.664 31.261  1    38     ? 240 ASP D OD1 1 
ATOM   7282 O  OD2 . ASP D 2 70  ? -38.711 -19.642 30.788  1    36.74  ? 240 ASP D OD2 1 
ATOM   7283 N  N   . ARG D 2 71  ? -34.687 -16.239 29.308  1    31.67  ? 241 ARG D N   1 
ATOM   7284 C  CA  . ARG D 2 71  ? -33.95  -15.441 28.331  1    33.86  ? 241 ARG D CA  1 
ATOM   7285 C  C   . ARG D 2 71  ? -32.454 -15.465 28.665  1    32.15  ? 241 ARG D C   1 
ATOM   7286 O  O   . ARG D 2 71  ? -31.62  -15.621 27.787  1    35.12  ? 241 ARG D O   1 
ATOM   7287 C  CB  . ARG D 2 71  ? -34.515 -14.023 28.205  1    30.77  ? 241 ARG D CB  1 
ATOM   7288 C  CG  . ARG D 2 71  ? -35.764 -13.981 27.345  1    33.39  ? 241 ARG D CG  1 
ATOM   7289 C  CD  . ARG D 2 71  ? -36.728 -12.866 27.677  1    32.1   ? 241 ARG D CD  1 
ATOM   7290 N  NE  . ARG D 2 71  ? -36.229 -11.647 27.049  1    37.49  ? 241 ARG D NE  1 
ATOM   7291 C  CZ  . ARG D 2 71  ? -36.264 -10.435 27.642  1    39.33  ? 241 ARG D CZ  1 
ATOM   7292 N  NH1 . ARG D 2 71  ? -36.993 -10.217 28.724  1    33.2   ? 241 ARG D NH1 1 
ATOM   7293 N  NH2 . ARG D 2 71  ? -35.574 -9.438  27.124  1    36.9   ? 241 ARG D NH2 1 
ATOM   7294 N  N   . PHE D 2 72  ? -32.129 -15.383 29.955  1    31.82  ? 242 PHE D N   1 
ATOM   7295 C  CA  . PHE D 2 72  ? -30.746 -15.379 30.396  1    32.11  ? 242 PHE D CA  1 
ATOM   7296 C  C   . PHE D 2 72  ? -30.066 -16.705 30.031  1    36.99  ? 242 PHE D C   1 
ATOM   7297 O  O   . PHE D 2 72  ? -28.957 -16.714 29.475  1    31.4   ? 242 PHE D O   1 
ATOM   7298 C  CB  . PHE D 2 72  ? -30.723 -15.119 31.904  1    27.76  ? 242 PHE D CB  1 
ATOM   7299 C  CG  . PHE D 2 72  ? -29.311 -14.945 32.431  1    28.23  ? 242 PHE D CG  1 
ATOM   7300 C  CD1 . PHE D 2 72  ? -28.67  -13.734 32.301  1    27.31  ? 242 PHE D CD1 1 
ATOM   7301 C  CD2 . PHE D 2 72  ? -28.637 -15.999 33.04   1    28.86  ? 242 PHE D CD2 1 
ATOM   7302 C  CE1 . PHE D 2 72  ? -27.393 -13.577 32.798  1    31.75  ? 242 PHE D CE1 1 
ATOM   7303 C  CE2 . PHE D 2 72  ? -27.364 -15.84  33.524  1    27.19  ? 242 PHE D CE2 1 
ATOM   7304 C  CZ  . PHE D 2 72  ? -26.758 -14.623 33.427  1    31.86  ? 242 PHE D CZ  1 
ATOM   7305 N  N   . LEU D 2 73  ? -30.747 -17.822 30.339  1    33.67  ? 243 LEU D N   1 
ATOM   7306 C  CA  . LEU D 2 73  ? -30.23  -19.147 30.064  1    32.15  ? 243 LEU D CA  1 
ATOM   7307 C  C   . LEU D 2 73  ? -30.229 -19.419 28.562  1    29.41  ? 243 LEU D C   1 
ATOM   7308 O  O   . LEU D 2 73  ? -29.619 -20.383 28.126  1    32.05  ? 243 LEU D O   1 
ATOM   7309 C  CB  . LEU D 2 73  ? -31.039 -20.192 30.837  1    31.66  ? 243 LEU D CB  1 
ATOM   7310 C  CG  . LEU D 2 73  ? -30.95  -20.108 32.366  1    31.15  ? 243 LEU D CG  1 
ATOM   7311 C  CD1 . LEU D 2 73  ? -31.923 -21.061 33.027  1    31.07  ? 243 LEU D CD1 1 
ATOM   7312 C  CD2 . LEU D 2 73  ? -29.529 -20.314 32.879  1    30.75  ? 243 LEU D CD2 1 
ATOM   7313 N  N   . SER D 2 74  ? -30.913 -18.591 27.782  1    29.88  ? 244 SER D N   1 
ATOM   7314 C  CA  . SER D 2 74  ? -30.894 -18.758 26.309  1    33.28  ? 244 SER D CA  1 
ATOM   7315 C  C   . SER D 2 74  ? -29.665 -18.056 25.729  1    32.46  ? 244 SER D C   1 
ATOM   7316 O  O   . SER D 2 74  ? -29.491 -18.091 24.504  1    34.3   ? 244 SER D O   1 
ATOM   7317 C  CB  . SER D 2 74  ? -32.15  -18.234 25.698  1    32.63  ? 244 SER D CB  1 
ATOM   7318 O  OG  . SER D 2 74  ? -33.29  -18.904 26.209  1    42.42  ? 244 SER D OG  1 
ATOM   7319 N  N   . SER D 2 75  ? -28.841 -17.463 26.585  1    38.26  ? 245 SER D N   1 
ATOM   7320 C  CA  . SER D 2 75  ? -27.682 -16.678 26.101  1    43.04  ? 245 SER D CA  1 
ATOM   7321 C  C   . SER D 2 75  ? -26.435 -16.981 26.933  1    39.56  ? 245 SER D C   1 
ATOM   7322 O  O   . SER D 2 75  ? -25.327 -16.714 26.443  1    43.56  ? 245 SER D O   1 
ATOM   7323 C  CB  . SER D 2 75  ? -27.996 -15.213 26.151  1    49.51  ? 245 SER D CB  1 
ATOM   7324 O  OG  . SER D 2 75  ? -28.207 -14.76  27.481  1    51.89  ? 245 SER D OG  1 
ATOM   7325 N  N   . MET D 2 76  ? -26.607 -17.521 28.135  1    35.05  ? 246 MET D N   1 
ATOM   7326 C  CA  . MET D 2 76  ? -25.43  -17.714 29.019  1    35.84  ? 246 MET D CA  1 
ATOM   7327 C  C   . MET D 2 76  ? -25.354 -19.14  29.567  1    33.15  ? 246 MET D C   1 
ATOM   7328 O  O   . MET D 2 76  ? -26.276 -19.524 30.298  1    32.31  ? 246 MET D O   1 
ATOM   7329 C  CB  . MET D 2 76  ? -25.473 -16.745 30.203  1    31.93  ? 246 MET D CB  1 
ATOM   7330 C  CG  . MET D 2 76  ? -25.648 -15.298 29.811  1    36.95  ? 246 MET D CG  1 
ATOM   7331 S  SD  . MET D 2 76  ? -24.066 -14.56  29.371  1    37.38  ? 246 MET D SD  1 
ATOM   7332 C  CE  . MET D 2 76  ? -23.34  -14.409 31.007  1    27.26  ? 246 MET D CE  1 
ATOM   7333 N  N   . SER D 2 77  ? -24.34  -19.787 29.44   1    29.08  ? 247 SER D N   1 
ATOM   7334 C  CA  . SER D 2 77  ? -24.073 -21.045 30.111  1    27.03  ? 247 SER D CA  1 
ATOM   7335 C  C   . SER D 2 77  ? -23.963 -20.744 31.601  1    29.04  ? 247 SER D C   1 
ATOM   7336 O  O   . SER D 2 77  ? -23.38  -19.73  31.974  1    32.33  ? 247 SER D O   1 
ATOM   7337 C  CB  . SER D 2 77  ? -22.808 -21.689 29.589  1    22.65  ? 247 SER D CB  1 
ATOM   7338 O  OG  . SER D 2 77  ? -22.868 -21.895 28.189  1    19.35  ? 247 SER D OG  1 
ATOM   7339 N  N   . VAL D 2 78  ? -24.556 -21.612 32.431  1    29.6   ? 248 VAL D N   1 
ATOM   7340 C  CA  . VAL D 2 78  ? -24.575 -21.456 33.883  1    26.55  ? 248 VAL D CA  1 
ATOM   7341 C  C   . VAL D 2 78  ? -24.334 -22.819 34.537  1    27.97  ? 248 VAL D C   1 
ATOM   7342 O  O   . VAL D 2 78  ? -24.898 -23.814 34.094  1    30.04  ? 248 VAL D O   1 
ATOM   7343 C  CB  . VAL D 2 78  ? -25.922 -20.861 34.336  1    26.55  ? 248 VAL D CB  1 
ATOM   7344 C  CG1 . VAL D 2 78  ? -26.138 -20.983 35.847  1    24.65  ? 248 VAL D CG1 1 
ATOM   7345 C  CG2 . VAL D 2 78  ? -26.076 -19.415 33.877  1    24.13  ? 248 VAL D CG2 1 
ATOM   7346 N  N   . LEU D 2 79  ? -23.489 -22.87  35.578  1    28.87  ? 249 LEU D N   1 
ATOM   7347 C  CA  . LEU D 2 79  ? -23.297 -24.105 36.329  1    31.61  ? 249 LEU D CA  1 
ATOM   7348 C  C   . LEU D 2 79  ? -24.41  -24.259 37.37   1    36.66  ? 249 LEU D C   1 
ATOM   7349 O  O   . LEU D 2 79  ? -25.07  -23.288 37.772  1    36.72  ? 249 LEU D O   1 
ATOM   7350 C  CB  . LEU D 2 79  ? -21.925 -24.19  36.996  1    31.76  ? 249 LEU D CB  1 
ATOM   7351 C  CG  . LEU D 2 79  ? -20.72  -24.263 36.052  1    37.56  ? 249 LEU D CG  1 
ATOM   7352 C  CD1 . LEU D 2 79  ? -19.456 -24.671 36.786  1    37.6   ? 249 LEU D CD1 1 
ATOM   7353 C  CD2 . LEU D 2 79  ? -20.948 -25.14  34.847  1    33.02  ? 249 LEU D CD2 1 
ATOM   7354 N  N   . ARG D 2 80  ? -24.658 -25.498 37.789  1    33.86  ? 250 ARG D N   1 
ATOM   7355 C  CA  . ARG D 2 80  ? -25.793 -25.783 38.709  1    34.76  ? 250 ARG D CA  1 
ATOM   7356 C  C   . ARG D 2 80  ? -25.707 -24.962 39.999  1    31.25  ? 250 ARG D C   1 
ATOM   7357 O  O   . ARG D 2 80  ? -26.736 -24.419 40.412  1    32.01  ? 250 ARG D O   1 
ATOM   7358 C  CB  . ARG D 2 80  ? -25.81  -27.281 39.028  1    36.29  ? 250 ARG D CB  1 
ATOM   7359 C  CG  . ARG D 2 80  ? -27.095 -27.784 39.665  1    41.22  ? 250 ARG D CG  1 
ATOM   7360 C  CD  . ARG D 2 80  ? -26.926 -29.178 40.238  1    49.25  ? 250 ARG D CD  1 
ATOM   7361 N  NE  . ARG D 2 80  ? -25.557 -29.683 40.101  1    43.83  ? 250 ARG D NE  1 
ATOM   7362 C  CZ  . ARG D 2 80  ? -25.205 -30.946 40.294  1    46.77  ? 250 ARG D CZ  1 
ATOM   7363 N  NH1 . ARG D 2 80  ? -25.872 -31.915 39.697  1    40.13  ? 250 ARG D NH1 1 
ATOM   7364 N  NH2 . ARG D 2 80  ? -24.188 -31.235 41.083  1    46     ? 250 ARG D NH2 1 
ATOM   7365 N  N   . GLY D 2 81  ? -24.53  -24.9   40.611  1    28.92  ? 251 GLY D N   1 
ATOM   7366 C  CA  . GLY D 2 81  ? -24.395 -24.198 41.875  1    27.28  ? 251 GLY D CA  1 
ATOM   7367 C  C   . GLY D 2 81  ? -24.818 -22.74  41.796  1    34.67  ? 251 GLY D C   1 
ATOM   7368 O  O   . GLY D 2 81  ? -24.884 -22.068 42.818  1    39.4   ? 251 GLY D O   1 
ATOM   7369 N  N   . LYS D 2 82  ? -25.074 -22.256 40.575  1    33.47  ? 252 LYS D N   1 
ATOM   7370 C  CA  . LYS D 2 82  ? -25.301 -20.843 40.354  1    31.16  ? 252 LYS D CA  1 
ATOM   7371 C  C   . LYS D 2 82  ? -26.669 -20.614 39.729  1    31.8   ? 252 LYS D C   1 
ATOM   7372 O  O   . LYS D 2 82  ? -27.058 -19.464 39.523  1    30.46  ? 252 LYS D O   1 
ATOM   7373 C  CB  . LYS D 2 82  ? -24.216 -20.277 39.428  1    31.38  ? 252 LYS D CB  1 
ATOM   7374 C  CG  . LYS D 2 82  ? -22.812 -20.212 39.999  1    28.47  ? 252 LYS D CG  1 
ATOM   7375 C  CD  . LYS D 2 82  ? -22.807 -19.285 41.201  1    30.26  ? 252 LYS D CD  1 
ATOM   7376 C  CE  . LYS D 2 82  ? -21.439 -18.805 41.594  1    32.68  ? 252 LYS D CE  1 
ATOM   7377 N  NZ  . LYS D 2 82  ? -20.679 -19.998 41.966  1    34.9   ? 252 LYS D NZ  1 
ATOM   7378 N  N   . LEU D 2 83  ? -27.374 -21.7   39.387  1    31.49  ? 253 LEU D N   1 
ATOM   7379 C  CA  . LEU D 2 83  ? -28.703 -21.588 38.803  1    30.35  ? 253 LEU D CA  1 
ATOM   7380 C  C   . LEU D 2 83  ? -29.616 -20.834 39.769  1    30.91  ? 253 LEU D C   1 
ATOM   7381 O  O   . LEU D 2 83  ? -30.386 -19.979 39.354  1    34.7   ? 253 LEU D O   1 
ATOM   7382 C  CB  . LEU D 2 83  ? -29.25  -22.98  38.518  1    30.52  ? 253 LEU D CB  1 
ATOM   7383 C  CG  . LEU D 2 83  ? -30.694 -23.046 38.021  1    29.49  ? 253 LEU D CG  1 
ATOM   7384 C  CD1 . LEU D 2 83  ? -30.848 -22.253 36.724  1    25.26  ? 253 LEU D CD1 1 
ATOM   7385 C  CD2 . LEU D 2 83  ? -31.026 -24.524 37.791  1    29.95  ? 253 LEU D CD2 1 
ATOM   7386 N  N   . GLN D 2 84  ? -29.51  -21.124 41.065  1    29.39  ? 254 GLN D N   1 
ATOM   7387 C  CA  . GLN D 2 84  ? -30.34  -20.41  42.018  1    33.53  ? 254 GLN D CA  1 
ATOM   7388 C  C   . GLN D 2 84  ? -29.979 -18.917 42.065  1    34.16  ? 254 GLN D C   1 
ATOM   7389 O  O   . GLN D 2 84  ? -30.837 -18.087 42.345  1    30.55  ? 254 GLN D O   1 
ATOM   7390 C  CB  . GLN D 2 84  ? -30.261 -21.053 43.399  1    30.61  ? 254 GLN D CB  1 
ATOM   7391 C  CG  . GLN D 2 84  ? -31.369 -20.532 44.298  1    32.68  ? 254 GLN D CG  1 
ATOM   7392 C  CD  . GLN D 2 84  ? -31.303 -21.041 45.717  1    36.32  ? 254 GLN D CD  1 
ATOM   7393 O  OE1 . GLN D 2 84  ? -32.264 -20.892 46.477  1    39.46  ? 254 GLN D OE1 1 
ATOM   7394 N  NE2 . GLN D 2 84  ? -30.177 -21.631 46.091  1    35.69  ? 254 GLN D NE2 1 
ATOM   7395 N  N   . LEU D 2 85  ? -28.703 -18.584 41.82   1    32.39  ? 255 LEU D N   1 
ATOM   7396 C  CA  . LEU D 2 85  ? -28.253 -17.211 41.923  1    34.06  ? 255 LEU D CA  1 
ATOM   7397 C  C   . LEU D 2 85  ? -28.902 -16.39  40.819  1    33.64  ? 255 LEU D C   1 
ATOM   7398 O  O   . LEU D 2 85  ? -29.259 -15.251 41.054  1    39.19  ? 255 LEU D O   1 
ATOM   7399 C  CB  . LEU D 2 85  ? -26.727 -17.129 41.883  1    33.41  ? 255 LEU D CB  1 
ATOM   7400 C  CG  . LEU D 2 85  ? -26.15  -15.715 41.92   1    32.13  ? 255 LEU D CG  1 
ATOM   7401 C  CD1 . LEU D 2 85  ? -26.634 -14.966 43.152  1    27.77  ? 255 LEU D CD1 1 
ATOM   7402 C  CD2 . LEU D 2 85  ? -24.656 -15.736 41.893  1    29.04  ? 255 LEU D CD2 1 
ATOM   7403 N  N   . VAL D 2 86  ? -29.086 -16.999 39.644  1    34.66  ? 256 VAL D N   1 
ATOM   7404 C  CA  . VAL D 2 86  ? -29.735 -16.375 38.501  1    30.08  ? 256 VAL D CA  1 
ATOM   7405 C  C   . VAL D 2 86  ? -31.209 -16.144 38.828  1    34.28  ? 256 VAL D C   1 
ATOM   7406 O  O   . VAL D 2 86  ? -31.753 -15.062 38.599  1    33.15  ? 256 VAL D O   1 
ATOM   7407 C  CB  . VAL D 2 86  ? -29.591 -17.273 37.259  1    26.67  ? 256 VAL D CB  1 
ATOM   7408 C  CG1 . VAL D 2 86  ? -30.428 -16.74  36.097  1    24.77  ? 256 VAL D CG1 1 
ATOM   7409 C  CG2 . VAL D 2 86  ? -28.135 -17.439 36.865  1    23.19  ? 256 VAL D CG2 1 
ATOM   7410 N  N   . GLY D 2 87  ? -31.854 -17.174 39.385  1    34.72  ? 257 GLY D N   1 
ATOM   7411 C  CA  . GLY D 2 87  ? -33.259 -17.093 39.754  1    33.49  ? 257 GLY D CA  1 
ATOM   7412 C  C   . GLY D 2 87  ? -33.534 -16.031 40.816  1    36.74  ? 257 GLY D C   1 
ATOM   7413 O  O   . GLY D 2 87  ? -34.539 -15.323 40.71   1    40.45  ? 257 GLY D O   1 
ATOM   7414 N  N   . THR D 2 88  ? -32.647 -15.931 41.823  1    31.06  ? 258 THR D N   1 
ATOM   7415 C  CA  . THR D 2 88  ? -32.813 -14.954 42.892  1    31.95  ? 258 THR D CA  1 
ATOM   7416 C  C   . THR D 2 88  ? -32.683 -13.558 42.28   1    32.44  ? 258 THR D C   1 
ATOM   7417 O  O   . THR D 2 88  ? -33.501 -12.689 42.55   1    30.73  ? 258 THR D O   1 
ATOM   7418 C  CB  . THR D 2 88  ? -31.799 -15.186 44.017  1    31.59  ? 258 THR D CB  1 
ATOM   7419 O  OG1 . THR D 2 88  ? -31.856 -16.555 44.394  1    39.55  ? 258 THR D OG1 1 
ATOM   7420 C  CG2 . THR D 2 88  ? -32.08  -14.371 45.265  1    29.34  ? 258 THR D CG2 1 
ATOM   7421 N  N   . ALA D 2 89  ? -31.668 -13.357 41.432  1    30.86  ? 259 ALA D N   1 
ATOM   7422 C  CA  . ALA D 2 89  ? -31.487 -12.066 40.782  1    33.72  ? 259 ALA D CA  1 
ATOM   7423 C  C   . ALA D 2 89  ? -32.702 -11.699 39.943  1    32.15  ? 259 ALA D C   1 
ATOM   7424 O  O   . ALA D 2 89  ? -33.16  -10.565 40.013  1    35.58  ? 259 ALA D O   1 
ATOM   7425 C  CB  . ALA D 2 89  ? -30.27  -12.07  39.926  1    35.86  ? 259 ALA D CB  1 
ATOM   7426 N  N   . ALA D 2 90  ? -33.242 -12.667 39.191  1    29.95  ? 260 ALA D N   1 
ATOM   7427 C  CA  . ALA D 2 90  ? -34.393 -12.399 38.327  1    29.41  ? 260 ALA D CA  1 
ATOM   7428 C  C   . ALA D 2 90  ? -35.636 -12.017 39.134  1    33.83  ? 260 ALA D C   1 
ATOM   7429 O  O   . ALA D 2 90  ? -36.378 -11.114 38.75   1    34.21  ? 260 ALA D O   1 
ATOM   7430 C  CB  . ALA D 2 90  ? -34.664 -13.582 37.466  1    27.99  ? 260 ALA D CB  1 
ATOM   7431 N  N   . MET D 2 91  ? -35.876 -12.721 40.246  1    32.41  ? 261 MET D N   1 
ATOM   7432 C  CA  . MET D 2 91  ? -37.012 -12.419 41.099  1    31.99  ? 261 MET D CA  1 
ATOM   7433 C  C   . MET D 2 91  ? -36.808 -11.015 41.667  1    35.57  ? 261 MET D C   1 
ATOM   7434 O  O   . MET D 2 91  ? -37.747 -10.226 41.73   1    39.96  ? 261 MET D O   1 
ATOM   7435 C  CB  . MET D 2 91  ? -37.102 -13.45  42.235  1    31.31  ? 261 MET D CB  1 
ATOM   7436 C  CG  . MET D 2 91  ? -38.451 -13.584 42.903  1    39.11  ? 261 MET D CG  1 
ATOM   7437 S  SD  . MET D 2 91  ? -39.753 -13.884 41.699  1    44.18  ? 261 MET D SD  1 
ATOM   7438 C  CE  . MET D 2 91  ? -41.037 -14.596 42.727  1    34.56  ? 261 MET D CE  1 
ATOM   7439 N  N   . LEU D 2 92  ? -35.564 -10.693 42.048  1    32.02  ? 262 LEU D N   1 
ATOM   7440 C  CA  . LEU D 2 92  ? -35.294 -9.383  42.596  1    32.44  ? 262 LEU D CA  1 
ATOM   7441 C  C   . LEU D 2 92  ? -35.665 -8.34   41.54   1    33.5   ? 262 LEU D C   1 
ATOM   7442 O  O   . LEU D 2 92  ? -36.348 -7.37   41.84   1    33.76  ? 262 LEU D O   1 
ATOM   7443 C  CB  . LEU D 2 92  ? -33.837 -9.265  43.047  1    28.79  ? 262 LEU D CB  1 
ATOM   7444 C  CG  . LEU D 2 92  ? -33.371 -7.84   43.389  1    25.8   ? 262 LEU D CG  1 
ATOM   7445 C  CD1 . LEU D 2 92  ? -34.202 -7.201  44.505  1    22.69  ? 262 LEU D CD1 1 
ATOM   7446 C  CD2 . LEU D 2 92  ? -31.917 -7.82   43.786  1    25.6   ? 262 LEU D CD2 1 
ATOM   7447 N  N   . LEU D 2 93  ? -35.202 -8.56   40.305  1    31.68  ? 263 LEU D N   1 
ATOM   7448 C  CA  . LEU D 2 93  ? -35.395 -7.606  39.227  1    31.56  ? 263 LEU D CA  1 
ATOM   7449 C  C   . LEU D 2 93  ? -36.871 -7.448  38.908  1    34.01  ? 263 LEU D C   1 
ATOM   7450 O  O   . LEU D 2 93  ? -37.311 -6.335  38.626  1    36.41  ? 263 LEU D O   1 
ATOM   7451 C  CB  . LEU D 2 93  ? -34.634 -8.047  37.983  1    27.82  ? 263 LEU D CB  1 
ATOM   7452 C  CG  . LEU D 2 93  ? -33.161 -7.651  37.954  1    27.28  ? 263 LEU D CG  1 
ATOM   7453 C  CD1 . LEU D 2 93  ? -32.496 -8.271  36.705  1    26.43  ? 263 LEU D CD1 1 
ATOM   7454 C  CD2 . LEU D 2 93  ? -33.056 -6.127  37.924  1    29.02  ? 263 LEU D CD2 1 
ATOM   7455 N  N   . ALA D 2 94  ? -37.6   -8.578  38.873  1    36.87  ? 264 ALA D N   1 
ATOM   7456 C  CA  . ALA D 2 94  ? -39.019 -8.574  38.546  1    33.72  ? 264 ALA D CA  1 
ATOM   7457 C  C   . ALA D 2 94  ? -39.799 -7.846  39.636  1    33.3   ? 264 ALA D C   1 
ATOM   7458 O  O   . ALA D 2 94  ? -40.689 -7.071  39.342  1    36.85  ? 264 ALA D O   1 
ATOM   7459 C  CB  . ALA D 2 94  ? -39.516 -9.97   38.36   1    32.61  ? 264 ALA D CB  1 
ATOM   7460 N  N   . SER D 2 95  ? -39.413 -8.053  40.893  1    31.29  ? 265 SER D N   1 
ATOM   7461 C  CA  . SER D 2 95  ? -40.016 -7.352  42.008  1    32.03  ? 265 SER D CA  1 
ATOM   7462 C  C   . SER D 2 95  ? -39.803 -5.845  41.891  1    35.62  ? 265 SER D C   1 
ATOM   7463 O  O   . SER D 2 95  ? -40.72  -5.052  42.128  1    41.52  ? 265 SER D O   1 
ATOM   7464 C  CB  . SER D 2 95  ? -39.49  -7.887  43.312  1    31.79  ? 265 SER D CB  1 
ATOM   7465 O  OG  . SER D 2 95  ? -39.849 -9.255  43.45   1    31.53  ? 265 SER D OG  1 
ATOM   7466 N  N   . LYS D 2 96  ? -38.587 -5.444  41.512  1    32.29  ? 266 LYS D N   1 
ATOM   7467 C  CA  . LYS D 2 96  ? -38.311 -4.032  41.316  1    28.96  ? 266 LYS D CA  1 
ATOM   7468 C  C   . LYS D 2 96  ? -39.106 -3.491  40.134  1    27.88  ? 266 LYS D C   1 
ATOM   7469 O  O   . LYS D 2 96  ? -39.473 -2.332  40.142  1    30.76  ? 266 LYS D O   1 
ATOM   7470 C  CB  . LYS D 2 96  ? -36.815 -3.807  41.096  1    30.05  ? 266 LYS D CB  1 
ATOM   7471 C  CG  . LYS D 2 96  ? -35.993 -3.952  42.367  1    30.03  ? 266 LYS D CG  1 
ATOM   7472 C  CD  . LYS D 2 96  ? -34.585 -3.438  42.094  1    28.2   ? 266 LYS D CD  1 
ATOM   7473 C  CE  . LYS D 2 96  ? -33.612 -3.592  43.225  1    27.61  ? 266 LYS D CE  1 
ATOM   7474 N  NZ  . LYS D 2 96  ? -32.257 -3.326  42.713  1    29.01  ? 266 LYS D NZ  1 
ATOM   7475 N  N   . PHE D 2 97  ? -39.366 -4.308  39.108  1    28.37  ? 267 PHE D N   1 
ATOM   7476 C  CA  . PHE D 2 97  ? -40.066 -3.785  37.952  1    28.53  ? 267 PHE D CA  1 
ATOM   7477 C  C   . PHE D 2 97  ? -41.535 -3.554  38.283  1    30.76  ? 267 PHE D C   1 
ATOM   7478 O  O   . PHE D 2 97  ? -42.066 -2.485  37.988  1    28.88  ? 267 PHE D O   1 
ATOM   7479 C  CB  . PHE D 2 97  ? -39.917 -4.682  36.732  1    28.77  ? 267 PHE D CB  1 
ATOM   7480 C  CG  . PHE D 2 97  ? -40.653 -4.173  35.501  1    34.65  ? 267 PHE D CG  1 
ATOM   7481 C  CD1 . PHE D 2 97  ? -40.052 -3.247  34.641  1    36.49  ? 267 PHE D CD1 1 
ATOM   7482 C  CD2 . PHE D 2 97  ? -41.93  -4.645  35.179  1    36.4   ? 267 PHE D CD2 1 
ATOM   7483 C  CE1 . PHE D 2 97  ? -40.712 -2.808  33.49   1    37.66  ? 267 PHE D CE1 1 
ATOM   7484 C  CE2 . PHE D 2 97  ? -42.583 -4.221  34.021  1    34.81  ? 267 PHE D CE2 1 
ATOM   7485 C  CZ  . PHE D 2 97  ? -41.974 -3.305  33.177  1    37.88  ? 267 PHE D CZ  1 
ATOM   7486 N  N   . GLU D 2 98  ? -42.136 -4.526  38.988  1    33.11  ? 268 GLU D N   1 
ATOM   7487 C  CA  . GLU D 2 98  ? -43.574 -4.76   38.956  1    33.57  ? 268 GLU D CA  1 
ATOM   7488 C  C   . GLU D 2 98  ? -44.27  -4.413  40.27   1    34.83  ? 268 GLU D C   1 
ATOM   7489 O  O   . GLU D 2 98  ? -45.452 -4.101  40.237  1    40.71  ? 268 GLU D O   1 
ATOM   7490 C  CB  . GLU D 2 98  ? -43.846 -6.242  38.705  1    32.48  ? 268 GLU D CB  1 
ATOM   7491 C  CG  . GLU D 2 98  ? -45.302 -6.558  38.384  1    34.44  ? 268 GLU D CG  1 
ATOM   7492 C  CD  . GLU D 2 98  ? -45.898 -5.802  37.201  1    36.2   ? 268 GLU D CD  1 
ATOM   7493 O  OE1 . GLU D 2 98  ? -45.176 -5.497  36.2    1    34.03  ? 268 GLU D OE1 1 
ATOM   7494 O  OE2 . GLU D 2 98  ? -47.128 -5.577  37.272  1    31.28  ? 268 GLU D OE2 1 
ATOM   7495 N  N   . GLU D 2 99  ? -43.573 -4.506  41.406  1    34.39  ? 269 GLU D N   1 
ATOM   7496 C  CA  . GLU D 2 99  ? -44.226 -4.399  42.707  1    33.31  ? 269 GLU D CA  1 
ATOM   7497 C  C   . GLU D 2 99  ? -44.184 -2.955  43.19   1    36.12  ? 269 GLU D C   1 
ATOM   7498 O  O   . GLU D 2 99  ? -43.185 -2.267  43.023  1    34.98  ? 269 GLU D O   1 
ATOM   7499 C  CB  . GLU D 2 99  ? -43.508 -5.209  43.793  1    31.68  ? 269 GLU D CB  1 
ATOM   7500 C  CG  . GLU D 2 99  ? -43.568 -6.731  43.642  1    28.44  ? 269 GLU D CG  1 
ATOM   7501 C  CD  . GLU D 2 99  ? -44.949 -7.337  43.846  1    33.36  ? 269 GLU D CD  1 
ATOM   7502 O  OE1 . GLU D 2 99  ? -45.677 -6.923  44.775  1    34.8   ? 269 GLU D OE1 1 
ATOM   7503 O  OE2 . GLU D 2 99  ? -45.303 -8.254  43.084  1    34.06  ? 269 GLU D OE2 1 
ATOM   7504 N  N   . ILE D 2 100 ? -45.271 -2.533  43.844  1    40.83  ? 270 ILE D N   1 
ATOM   7505 C  CA  . ILE D 2 100 ? -45.337 -1.269  44.558  1    36     ? 270 ILE D CA  1 
ATOM   7506 C  C   . ILE D 2 100 ? -44.291 -1.249  45.683  1    38.17  ? 270 ILE D C   1 
ATOM   7507 O  O   . ILE D 2 100 ? -43.565 -0.271  45.84   1    40.84  ? 270 ILE D O   1 
ATOM   7508 C  CB  . ILE D 2 100 ? -46.755 -1.08   45.122  1    34     ? 270 ILE D CB  1 
ATOM   7509 C  CG1 . ILE D 2 100 ? -47.832 -1.061  44.052  1    31.34  ? 270 ILE D CG1 1 
ATOM   7510 C  CG2 . ILE D 2 100 ? -46.836 0.162   46.007  1    33.96  ? 270 ILE D CG2 1 
ATOM   7511 C  CD1 . ILE D 2 100 ? -49.231 -0.843  44.627  1    25.08  ? 270 ILE D CD1 1 
ATOM   7512 N  N   . TYR D 2 101 ? -44.263 -2.321  46.49   1    36.36  ? 271 TYR D N   1 
ATOM   7513 C  CA  . TYR D 2 101 ? -43.401 -2.454  47.653  1    32.67  ? 271 TYR D CA  1 
ATOM   7514 C  C   . TYR D 2 101 ? -42.532 -3.71   47.507  1    33.83  ? 271 TYR D C   1 
ATOM   7515 O  O   . TYR D 2 101 ? -42.831 -4.744  48.094  1    33.3   ? 271 TYR D O   1 
ATOM   7516 C  CB  . TYR D 2 101 ? -44.278 -2.611  48.898  1    32.2   ? 271 TYR D CB  1 
ATOM   7517 C  CG  . TYR D 2 101 ? -45.196 -1.434  49.189  1    36.27  ? 271 TYR D CG  1 
ATOM   7518 C  CD1 . TYR D 2 101 ? -44.672 -0.235  49.677  1    32.33  ? 271 TYR D CD1 1 
ATOM   7519 C  CD2 . TYR D 2 101 ? -46.586 -1.529  48.981  1    35.87  ? 271 TYR D CD2 1 
ATOM   7520 C  CE1 . TYR D 2 101 ? -45.51  0.838   49.935  1    35.62  ? 271 TYR D CE1 1 
ATOM   7521 C  CE2 . TYR D 2 101 ? -47.427 -0.457  49.242  1    34.66  ? 271 TYR D CE2 1 
ATOM   7522 C  CZ  . TYR D 2 101 ? -46.887 0.728   49.729  1    38.8   ? 271 TYR D CZ  1 
ATOM   7523 O  OH  . TYR D 2 101 ? -47.706 1.813   49.972  1    43.07  ? 271 TYR D OH  1 
ATOM   7524 N  N   . PRO D 2 102 ? -41.44  -3.69   46.701  1    31.78  ? 272 PRO D N   1 
ATOM   7525 C  CA  . PRO D 2 102 ? -40.607 -4.884  46.527  1    27.4   ? 272 PRO D CA  1 
ATOM   7526 C  C   . PRO D 2 102 ? -39.942 -5.239  47.844  1    30.07  ? 272 PRO D C   1 
ATOM   7527 O  O   . PRO D 2 102 ? -39.833 -4.387  48.731  1    35.76  ? 272 PRO D O   1 
ATOM   7528 C  CB  . PRO D 2 102 ? -39.573 -4.512  45.479  1    24.98  ? 272 PRO D CB  1 
ATOM   7529 C  CG  . PRO D 2 102 ? -39.656 -3.008  45.344  1    26.5   ? 272 PRO D CG  1 
ATOM   7530 C  CD  . PRO D 2 102 ? -40.984 -2.538  45.898  1    27.05  ? 272 PRO D CD  1 
ATOM   7531 N  N   . PRO D 2 103 ? -39.577 -6.52   48.07   1    29.45  ? 273 PRO D N   1 
ATOM   7532 C  CA  . PRO D 2 103 ? -38.763 -6.866  49.228  1    31.21  ? 273 PRO D CA  1 
ATOM   7533 C  C   . PRO D 2 103 ? -37.355 -6.319  49.028  1    34.5   ? 273 PRO D C   1 
ATOM   7534 O  O   . PRO D 2 103 ? -36.851 -6.256  47.901  1    37.75  ? 273 PRO D O   1 
ATOM   7535 C  CB  . PRO D 2 103 ? -38.803 -8.399  49.205  1    29.47  ? 273 PRO D CB  1 
ATOM   7536 C  CG  . PRO D 2 103 ? -40.047 -8.722  48.419  1    28.86  ? 273 PRO D CG  1 
ATOM   7537 C  CD  . PRO D 2 103 ? -40.03  -7.703  47.321  1    29.11  ? 273 PRO D CD  1 
ATOM   7538 N  N   . GLU D 2 104 ? -36.724 -5.956  50.142  1    32.52  ? 274 GLU D N   1 
ATOM   7539 C  CA  . GLU D 2 104 ? -35.348 -5.497  50.126  1    40.31  ? 274 GLU D CA  1 
ATOM   7540 C  C   . GLU D 2 104 ? -34.424 -6.634  49.695  1    38.99  ? 274 GLU D C   1 
ATOM   7541 O  O   . GLU D 2 104 ? -34.787 -7.81   49.808  1    40.23  ? 274 GLU D O   1 
ATOM   7542 C  CB  . GLU D 2 104 ? -35.032 -4.994  51.536  1    48.98  ? 274 GLU D CB  1 
ATOM   7543 C  CG  . GLU D 2 104 ? -35.807 -3.736  51.924  1    49.05  ? 274 GLU D CG  1 
ATOM   7544 C  CD  . GLU D 2 104 ? -35.416 -3.314  53.326  1    61.8   ? 274 GLU D CD  1 
ATOM   7545 O  OE1 . GLU D 2 104 ? -34.985 -2.153  53.481  1    76.17  ? 274 GLU D OE1 1 
ATOM   7546 O  OE2 . GLU D 2 104 ? -35.48  -4.158  54.249  1    57.91  ? 274 GLU D OE2 1 
ATOM   7547 N  N   . VAL D 2 105 ? -33.237 -6.271  49.188  1    33.05  ? 275 VAL D N   1 
ATOM   7548 C  CA  . VAL D 2 105 ? -32.256 -7.243  48.694  1    30.67  ? 275 VAL D CA  1 
ATOM   7549 C  C   . VAL D 2 105 ? -31.897 -8.229  49.813  1    30.25  ? 275 VAL D C   1 
ATOM   7550 O  O   . VAL D 2 105 ? -31.714 -9.423  49.578  1    26.75  ? 275 VAL D O   1 
ATOM   7551 C  CB  . VAL D 2 105 ? -30.989 -6.526  48.166  1    29.01  ? 275 VAL D CB  1 
ATOM   7552 C  CG1 . VAL D 2 105 ? -29.924 -7.492  47.706  1    24.62  ? 275 VAL D CG1 1 
ATOM   7553 C  CG2 . VAL D 2 105 ? -31.279 -5.522  47.055  1    30.53  ? 275 VAL D CG2 1 
ATOM   7554 N  N   . ALA D 2 106 ? -31.816 -7.727  51.056  1    29.55  ? 276 ALA D N   1 
ATOM   7555 C  CA  . ALA D 2 106 ? -31.549 -8.609  52.184  1    31.51  ? 276 ALA D CA  1 
ATOM   7556 C  C   . ALA D 2 106 ? -32.531 -9.79   52.234  1    33.35  ? 276 ALA D C   1 
ATOM   7557 O  O   . ALA D 2 106 ? -32.119 -10.898 52.554  1    35.14  ? 276 ALA D O   1 
ATOM   7558 C  CB  . ALA D 2 106 ? -31.501 -7.844  53.468  1    23.19  ? 276 ALA D CB  1 
ATOM   7559 N  N   . GLU D 2 107 ? -33.808 -9.566  51.898  1    31.58  ? 277 GLU D N   1 
ATOM   7560 C  CA  . GLU D 2 107 ? -34.79  -10.64  51.917  1    35.15  ? 277 GLU D CA  1 
ATOM   7561 C  C   . GLU D 2 107 ? -34.411 -11.7   50.874  1    39.9   ? 277 GLU D C   1 
ATOM   7562 O  O   . GLU D 2 107 ? -34.518 -12.915 51.099  1    43.95  ? 277 GLU D O   1 
ATOM   7563 C  CB  . GLU D 2 107 ? -36.216 -10.133 51.693  1    37.75  ? 277 GLU D CB  1 
ATOM   7564 C  CG  . GLU D 2 107 ? -36.803 -9.3    52.835  1    43.64  ? 277 GLU D CG  1 
ATOM   7565 C  CD  . GLU D 2 107 ? -36.733 -9.993  54.186  1    58.14  ? 277 GLU D CD  1 
ATOM   7566 O  OE1 . GLU D 2 107 ? -36.297 -9.335  55.139  1    70.03  ? 277 GLU D OE1 1 
ATOM   7567 O  OE2 . GLU D 2 107 ? -37.102 -11.186 54.306  1    70.99  ? 277 GLU D OE2 1 
ATOM   7568 N  N   . PHE D 2 108 ? -33.905 -11.245 49.726  1    35.56  ? 278 PHE D N   1 
ATOM   7569 C  CA  . PHE D 2 108 ? -33.603 -12.188 48.674  1    33.59  ? 278 PHE D CA  1 
ATOM   7570 C  C   . PHE D 2 108 ? -32.39  -13.027 49.057  1    36.9   ? 278 PHE D C   1 
ATOM   7571 O  O   . PHE D 2 108 ? -32.285 -14.193 48.654  1    38.34  ? 278 PHE D O   1 
ATOM   7572 C  CB  . PHE D 2 108 ? -33.41  -11.417 47.372  1    33.28  ? 278 PHE D CB  1 
ATOM   7573 C  CG  . PHE D 2 108 ? -34.736 -11.012 46.77   1    33.76  ? 278 PHE D CG  1 
ATOM   7574 C  CD1 . PHE D 2 108 ? -35.483 -11.942 46.037  1    34.18  ? 278 PHE D CD1 1 
ATOM   7575 C  CD2 . PHE D 2 108 ? -35.215 -9.721  46.93   1    30.07  ? 278 PHE D CD2 1 
ATOM   7576 C  CE1 . PHE D 2 108 ? -36.674 -11.572 45.434  1    34.07  ? 278 PHE D CE1 1 
ATOM   7577 C  CE2 . PHE D 2 108 ? -36.429 -9.367  46.349  1    36.8   ? 278 PHE D CE2 1 
ATOM   7578 C  CZ  . PHE D 2 108 ? -37.151 -10.285 45.592  1    36.8   ? 278 PHE D CZ  1 
ATOM   7579 N  N   . VAL D 2 109 ? -31.477 -12.418 49.82   1    33.89  ? 279 VAL D N   1 
ATOM   7580 C  CA  . VAL D 2 109 ? -30.32  -13.146 50.312  1    35.64  ? 279 VAL D CA  1 
ATOM   7581 C  C   . VAL D 2 109 ? -30.768 -14.155 51.369  1    36.14  ? 279 VAL D C   1 
ATOM   7582 O  O   . VAL D 2 109 ? -30.203 -15.246 51.48   1    34.25  ? 279 VAL D O   1 
ATOM   7583 C  CB  . VAL D 2 109 ? -29.246 -12.196 50.87   1    33.25  ? 279 VAL D CB  1 
ATOM   7584 C  CG1 . VAL D 2 109 ? -28.102 -12.963 51.516  1    27.97  ? 279 VAL D CG1 1 
ATOM   7585 C  CG2 . VAL D 2 109 ? -28.719 -11.273 49.781  1    37.09  ? 279 VAL D CG2 1 
ATOM   7586 N  N   . TYR D 2 110 ? -31.778 -13.772 52.157  1    36.08  ? 280 TYR D N   1 
ATOM   7587 C  CA  . TYR D 2 110 ? -32.185 -14.584 53.283  1    34.82  ? 280 TYR D CA  1 
ATOM   7588 C  C   . TYR D 2 110 ? -32.813 -15.876 52.762  1    35.27  ? 280 TYR D C   1 
ATOM   7589 O  O   . TYR D 2 110 ? -32.565 -16.928 53.338  1    31.91  ? 280 TYR D O   1 
ATOM   7590 C  CB  . TYR D 2 110 ? -33.082 -13.757 54.196  1    36.73  ? 280 TYR D CB  1 
ATOM   7591 C  CG  . TYR D 2 110 ? -33.783 -14.574 55.271  1    46.73  ? 280 TYR D CG  1 
ATOM   7592 C  CD1 . TYR D 2 110 ? -33.192 -14.786 56.517  1    48     ? 280 TYR D CD1 1 
ATOM   7593 C  CD2 . TYR D 2 110 ? -35.04  -15.129 55.032  1    47.95  ? 280 TYR D CD2 1 
ATOM   7594 C  CE1 . TYR D 2 110 ? -33.856 -15.492 57.506  1    53.47  ? 280 TYR D CE1 1 
ATOM   7595 C  CE2 . TYR D 2 110 ? -35.698 -15.863 56.004  1    50.46  ? 280 TYR D CE2 1 
ATOM   7596 C  CZ  . TYR D 2 110 ? -35.111 -16.03  57.245  1    53.42  ? 280 TYR D CZ  1 
ATOM   7597 O  OH  . TYR D 2 110 ? -35.808 -16.756 58.163  1    56.1   ? 280 TYR D OH  1 
ATOM   7598 N  N   . ILE D 2 111 ? -33.568 -15.8   51.65   1    34.02  ? 281 ILE D N   1 
ATOM   7599 C  CA  . ILE D 2 111 ? -34.304 -16.948 51.139  1    38.49  ? 281 ILE D CA  1 
ATOM   7600 C  C   . ILE D 2 111 ? -33.399 -17.996 50.477  1    42.13  ? 281 ILE D C   1 
ATOM   7601 O  O   . ILE D 2 111 ? -33.868 -19.097 50.19   1    42.46  ? 281 ILE D O   1 
ATOM   7602 C  CB  . ILE D 2 111 ? -35.421 -16.528 50.165  1    40.83  ? 281 ILE D CB  1 
ATOM   7603 C  CG1 . ILE D 2 111 ? -34.861 -15.702 49.016  1    38.68  ? 281 ILE D CG1 1 
ATOM   7604 C  CG2 . ILE D 2 111 ? -36.566 -15.828 50.898  1    40.62  ? 281 ILE D CG2 1 
ATOM   7605 C  CD1 . ILE D 2 111 ? -35.862 -15.386 47.925  1    42.45  ? 281 ILE D CD1 1 
ATOM   7606 N  N   . THR D 2 112 ? -32.138 -17.66  50.164  1    41.95  ? 282 THR D N   1 
ATOM   7607 C  CA  . THR D 2 112 ? -31.232 -18.637 49.569  1    43.62  ? 282 THR D CA  1 
ATOM   7608 C  C   . THR D 2 112 ? -30.5   -19.429 50.649  1    48.81  ? 282 THR D C   1 
ATOM   7609 O  O   . THR D 2 112 ? -29.628 -20.241 50.311  1    52.39  ? 282 THR D O   1 
ATOM   7610 C  CB  . THR D 2 112 ? -30.219 -17.999 48.617  1    41.19  ? 282 THR D CB  1 
ATOM   7611 O  OG1 . THR D 2 112 ? -29.486 -17.028 49.356  1    43.24  ? 282 THR D OG1 1 
ATOM   7612 C  CG2 . THR D 2 112 ? -30.847 -17.406 47.373  1    32.62  ? 282 THR D CG2 1 
ATOM   7613 N  N   . ASP D 2 113 ? -30.848 -19.161 51.924  1    51.16  ? 283 ASP D N   1 
ATOM   7614 C  CA  . ASP D 2 113 ? -30.255 -19.771 53.108  1    52.04  ? 283 ASP D CA  1 
ATOM   7615 C  C   . ASP D 2 113 ? -28.768 -19.425 53.22   1    50.86  ? 283 ASP D C   1 
ATOM   7616 O  O   . ASP D 2 113 ? -27.954 -20.239 53.676  1    41.13  ? 283 ASP D O   1 
ATOM   7617 C  CB  . ASP D 2 113 ? -30.547 -21.262 53.204  1    65.86  ? 283 ASP D CB  1 
ATOM   7618 C  CG  . ASP D 2 113 ? -31.904 -21.615 53.792  1    80.34  ? 283 ASP D CG  1 
ATOM   7619 O  OD1 . ASP D 2 113 ? -32.371 -20.86  54.685  1    80.62  ? 283 ASP D OD1 1 
ATOM   7620 O  OD2 . ASP D 2 113 ? -32.46  -22.667 53.39   1    88.64  ? 283 ASP D OD2 1 
ATOM   7621 N  N   . ASP D 2 114 ? -28.433 -18.189 52.827  1    56.63  ? 284 ASP D N   1 
ATOM   7622 C  CA  . ASP D 2 114 ? -27.047 -17.75  52.744  1    69.79  ? 284 ASP D CA  1 
ATOM   7623 C  C   . ASP D 2 114 ? -26.205 -18.74  51.918  1    66.15  ? 284 ASP D C   1 
ATOM   7624 O  O   . ASP D 2 114 ? -25.009 -18.919 52.181  1    54.57  ? 284 ASP D O   1 
ATOM   7625 C  CB  . ASP D 2 114 ? -26.487 -17.426 54.125  1    89.49  ? 284 ASP D CB  1 
ATOM   7626 C  CG  . ASP D 2 114 ? -27.351 -16.536 55.014  1    94.14  ? 284 ASP D CG  1 
ATOM   7627 O  OD1 . ASP D 2 114 ? -27.823 -15.478 54.518  1    89.02  ? 284 ASP D OD1 1 
ATOM   7628 O  OD2 . ASP D 2 114 ? -27.526 -16.894 56.208  1    89.28  ? 284 ASP D OD2 1 
ATOM   7629 N  N   . THR D 2 115 ? -26.822 -19.372 50.898  1    52.22  ? 285 THR D N   1 
ATOM   7630 C  CA  . THR D 2 115 ? -26.045 -20.029 49.864  1    48.8   ? 285 THR D CA  1 
ATOM   7631 C  C   . THR D 2 115 ? -25.187 -18.97  49.157  1    51.61  ? 285 THR D C   1 
ATOM   7632 O  O   . THR D 2 115 ? -24.062 -19.261 48.741  1    51.96  ? 285 THR D O   1 
ATOM   7633 C  CB  . THR D 2 115 ? -26.939 -20.746 48.855  1    53.53  ? 285 THR D CB  1 
ATOM   7634 O  OG1 . THR D 2 115 ? -27.911 -21.573 49.488  1    50.88  ? 285 THR D OG1 1 
ATOM   7635 C  CG2 . THR D 2 115 ? -26.113 -21.534 47.849  1    46.88  ? 285 THR D CG2 1 
ATOM   7636 N  N   . TYR D 2 116 ? -25.73  -17.749 48.994  1    38.5   ? 286 TYR D N   1 
ATOM   7637 C  CA  . TYR D 2 116 ? -25.029 -16.693 48.283  1    38.42  ? 286 TYR D CA  1 
ATOM   7638 C  C   . TYR D 2 116 ? -24.909 -15.469 49.18   1    41.37  ? 286 TYR D C   1 
ATOM   7639 O  O   . TYR D 2 116 ? -25.694 -15.326 50.116  1    45.98  ? 286 TYR D O   1 
ATOM   7640 C  CB  . TYR D 2 116 ? -25.752 -16.328 46.985  1    34.38  ? 286 TYR D CB  1 
ATOM   7641 C  CG  . TYR D 2 116 ? -26.047 -17.514 46.078  1    32.79  ? 286 TYR D CG  1 
ATOM   7642 C  CD1 . TYR D 2 116 ? -25.018 -18.249 45.492  1    32.02  ? 286 TYR D CD1 1 
ATOM   7643 C  CD2 . TYR D 2 116 ? -27.348 -17.902 45.81   1    29.84  ? 286 TYR D CD2 1 
ATOM   7644 C  CE1 . TYR D 2 116 ? -25.267 -19.34  44.678  1    27.4   ? 286 TYR D CE1 1 
ATOM   7645 C  CE2 . TYR D 2 116 ? -27.615 -18.987 44.991  1    30.05  ? 286 TYR D CE2 1 
ATOM   7646 C  CZ  . TYR D 2 116 ? -26.576 -19.705 44.413  1    30.87  ? 286 TYR D CZ  1 
ATOM   7647 O  OH  . TYR D 2 116 ? -26.84  -20.746 43.555  1    31.1   ? 286 TYR D OH  1 
ATOM   7648 N  N   . THR D 2 117 ? -23.904 -14.62  48.894  1    40.16  ? 287 THR D N   1 
ATOM   7649 C  CA  . THR D 2 117 ? -23.69  -13.356 49.595  1    43.58  ? 287 THR D CA  1 
ATOM   7650 C  C   . THR D 2 117 ? -24.584 -12.302 48.964  1    44.96  ? 287 THR D C   1 
ATOM   7651 O  O   . THR D 2 117 ? -25.088 -12.509 47.858  1    50.86  ? 287 THR D O   1 
ATOM   7652 C  CB  . THR D 2 117 ? -22.247 -12.845 49.531  1    43.74  ? 287 THR D CB  1 
ATOM   7653 O  OG1 . THR D 2 117 ? -21.955 -12.713 48.144  1    46.88  ? 287 THR D OG1 1 
ATOM   7654 C  CG2 . THR D 2 117 ? -21.234 -13.751 50.203  1    36.76  ? 287 THR D CG2 1 
ATOM   7655 N  N   . LYS D 2 118 ? -24.711 -11.155 49.643  1    42.6   ? 288 LYS D N   1 
ATOM   7656 C  CA  . LYS D 2 118 ? -25.477 -10.057 49.091  1    38.93  ? 288 LYS D CA  1 
ATOM   7657 C  C   . LYS D 2 118 ? -24.748 -9.556  47.845  1    43.74  ? 288 LYS D C   1 
ATOM   7658 O  O   . LYS D 2 118 ? -25.384 -9.308  46.818  1    49.33  ? 288 LYS D O   1 
ATOM   7659 C  CB  . LYS D 2 118 ? -25.67  -9.01   50.191  1    37.92  ? 288 LYS D CB  1 
ATOM   7660 C  CG  . LYS D 2 118 ? -26.579 -7.824  49.89   1    39.38  ? 288 LYS D CG  1 
ATOM   7661 C  CD  . LYS D 2 118 ? -26.525 -6.944  51.14   1    45.47  ? 288 LYS D CD  1 
ATOM   7662 C  CE  . LYS D 2 118 ? -27.501 -5.819  51.256  1    49.11  ? 288 LYS D CE  1 
ATOM   7663 N  NZ  . LYS D 2 118 ? -27.489 -5.285  52.625  1    53.57  ? 288 LYS D NZ  1 
ATOM   7664 N  N   . LYS D 2 119 ? -23.414 -9.45   47.94   1    38.76  ? 289 LYS D N   1 
ATOM   7665 C  CA  . LYS D 2 119 ? -22.581 -8.948  46.859  1    39.37  ? 289 LYS D CA  1 
ATOM   7666 C  C   . LYS D 2 119 ? -22.787 -9.803  45.608  1    37.65  ? 289 LYS D C   1 
ATOM   7667 O  O   . LYS D 2 119 ? -22.776 -9.277  44.487  1    36.25  ? 289 LYS D O   1 
ATOM   7668 C  CB  . LYS D 2 119 ? -21.108 -8.916  47.297  1    47.25  ? 289 LYS D CB  1 
ATOM   7669 C  CG  . LYS D 2 119 ? -20.07  -8.453  46.272  1    52.05  ? 289 LYS D CG  1 
ATOM   7670 C  CD  . LYS D 2 119 ? -19.944 -6.955  45.972  1    66.62  ? 289 LYS D CD  1 
ATOM   7671 C  CE  . LYS D 2 119 ? -18.858 -6.213  46.744  1    72.69  ? 289 LYS D CE  1 
ATOM   7672 N  NZ  . LYS D 2 119 ? -17.604 -6.977  46.879  1    59.28  ? 289 LYS D NZ  1 
ATOM   7673 N  N   . GLN D 2 120 ? -22.974 -11.122 45.796  1    34.53  ? 290 GLN D N   1 
ATOM   7674 C  CA  . GLN D 2 120 ? -23.221 -12.018 44.671  1    35.49  ? 290 GLN D CA  1 
ATOM   7675 C  C   . GLN D 2 120 ? -24.567 -11.72  44.004  1    34.91  ? 290 GLN D C   1 
ATOM   7676 O  O   . GLN D 2 120 ? -24.669 -11.66  42.78   1    37.08  ? 290 GLN D O   1 
ATOM   7677 C  CB  . GLN D 2 120 ? -23.139 -13.478 45.088  1    35.37  ? 290 GLN D CB  1 
ATOM   7678 C  CG  . GLN D 2 120 ? -21.711 -14.002 45.198  1    36.21  ? 290 GLN D CG  1 
ATOM   7679 C  CD  . GLN D 2 120 ? -21.691 -15.446 45.647  1    41.11  ? 290 GLN D CD  1 
ATOM   7680 O  OE1 . GLN D 2 120 ? -22.249 -15.81  46.69   1    41.14  ? 290 GLN D OE1 1 
ATOM   7681 N  NE2 . GLN D 2 120 ? -21.148 -16.306 44.796  1    42.28  ? 290 GLN D NE2 1 
ATOM   7682 N  N   . VAL D 2 121 ? -25.601 -11.509 44.815  1    29.42  ? 291 VAL D N   1 
ATOM   7683 C  CA  . VAL D 2 121 ? -26.921 -11.269 44.287  1    27.52  ? 291 VAL D CA  1 
ATOM   7684 C  C   . VAL D 2 121 ? -26.931 -9.951  43.532  1    29.69  ? 291 VAL D C   1 
ATOM   7685 O  O   . VAL D 2 121 ? -27.512 -9.856  42.445  1    33.28  ? 291 VAL D O   1 
ATOM   7686 C  CB  . VAL D 2 121 ? -27.953 -11.279 45.425  1    29.8   ? 291 VAL D CB  1 
ATOM   7687 C  CG1 . VAL D 2 121 ? -29.269 -10.61  45.007  1    23.29  ? 291 VAL D CG1 1 
ATOM   7688 C  CG2 . VAL D 2 121 ? -28.135 -12.704 45.961  1    25.07  ? 291 VAL D CG2 1 
ATOM   7689 N  N   . LEU D 2 122 ? -26.31  -8.934  44.128  1    29.95  ? 292 LEU D N   1 
ATOM   7690 C  CA  . LEU D 2 122 ? -26.269 -7.603  43.528  1    31.89  ? 292 LEU D CA  1 
ATOM   7691 C  C   . LEU D 2 122 ? -25.543 -7.624  42.193  1    30.53  ? 292 LEU D C   1 
ATOM   7692 O  O   . LEU D 2 122 ? -26.034 -7.008  41.253  1    28.1   ? 292 LEU D O   1 
ATOM   7693 C  CB  . LEU D 2 122 ? -25.598 -6.629  44.479  1    30.27  ? 292 LEU D CB  1 
ATOM   7694 C  CG  . LEU D 2 122 ? -26.463 -6.28   45.687  1    34.66  ? 292 LEU D CG  1 
ATOM   7695 C  CD1 . LEU D 2 122 ? -25.713 -5.351  46.63   1    33.84  ? 292 LEU D CD1 1 
ATOM   7696 C  CD2 . LEU D 2 122 ? -27.817 -5.712  45.183  1    34.88  ? 292 LEU D CD2 1 
ATOM   7697 N  N   . ARG D 2 123 ? -24.403 -8.34   42.141  1    26.28  ? 293 ARG D N   1 
ATOM   7698 C  CA  . ARG D 2 123 ? -23.646 -8.459  40.908  1    28.54  ? 293 ARG D CA  1 
ATOM   7699 C  C   . ARG D 2 123 ? -24.415 -9.268  39.852  1    28.75  ? 293 ARG D C   1 
ATOM   7700 O  O   . ARG D 2 123 ? -24.375 -8.947  38.67   1    26.77  ? 293 ARG D O   1 
ATOM   7701 C  CB  . ARG D 2 123 ? -22.273 -9.044  41.213  1    29.97  ? 293 ARG D CB  1 
ATOM   7702 C  CG  . ARG D 2 123 ? -21.318 -8.005  41.785  1    35.04  ? 293 ARG D CG  1 
ATOM   7703 C  CD  . ARG D 2 123 ? -19.946 -8.593  42.014  1    50.1   ? 293 ARG D CD  1 
ATOM   7704 N  NE  . ARG D 2 123 ? -18.879 -7.589  42.04   1    80.72  ? 293 ARG D NE  1 
ATOM   7705 C  CZ  . ARG D 2 123 ? -17.609 -7.852  42.375  1    104.05 ? 293 ARG D CZ  1 
ATOM   7706 N  NH1 . ARG D 2 123 ? -17.259 -9.069  42.773  1    101.43 ? 293 ARG D NH1 1 
ATOM   7707 N  NH2 . ARG D 2 123 ? -16.688 -6.896  42.32   1    101.51 ? 293 ARG D NH2 1 
ATOM   7708 N  N   . MET D 2 124 ? -25.117 -10.324 40.27   1    29.44  ? 294 MET D N   1 
ATOM   7709 C  CA  . MET D 2 124 ? -25.866 -11.101 39.31   1    28.97  ? 294 MET D CA  1 
ATOM   7710 C  C   . MET D 2 124 ? -26.991 -10.232 38.769  1    30.8   ? 294 MET D C   1 
ATOM   7711 O  O   . MET D 2 124 ? -27.277 -10.303 37.58   1    33.48  ? 294 MET D O   1 
ATOM   7712 C  CB  . MET D 2 124 ? -26.426 -12.386 39.899  1    24.04  ? 294 MET D CB  1 
ATOM   7713 C  CG  . MET D 2 124 ? -27.245 -13.171 38.894  1    25.9   ? 294 MET D CG  1 
ATOM   7714 S  SD  . MET D 2 124 ? -26.303 -13.859 37.514  1    32.05  ? 294 MET D SD  1 
ATOM   7715 C  CE  . MET D 2 124 ? -25.532 -15.238 38.374  1    26.01  ? 294 MET D CE  1 
ATOM   7716 N  N   . GLU D 2 125 ? -27.572 -9.381  39.628  1    30.65  ? 295 GLU D N   1 
ATOM   7717 C  CA  . GLU D 2 125 ? -28.585 -8.426  39.185  1    31.27  ? 295 GLU D CA  1 
ATOM   7718 C  C   . GLU D 2 125 ? -28.074 -7.624  37.985  1    30.6   ? 295 GLU D C   1 
ATOM   7719 O  O   . GLU D 2 125 ? -28.747 -7.56   36.959  1    35.96  ? 295 GLU D O   1 
ATOM   7720 C  CB  . GLU D 2 125 ? -29.037 -7.47   40.292  1    27.97  ? 295 GLU D CB  1 
ATOM   7721 C  CG  . GLU D 2 125 ? -30.083 -6.437  39.848  1    25.53  ? 295 GLU D CG  1 
ATOM   7722 C  CD  . GLU D 2 125 ? -30.529 -5.431  40.906  1    30.11  ? 295 GLU D CD  1 
ATOM   7723 O  OE1 . GLU D 2 125 ? -29.725 -4.504  41.288  1    30.8   ? 295 GLU D OE1 1 
ATOM   7724 O  OE2 . GLU D 2 125 ? -31.69  -5.572  41.363  1    26.36  ? 295 GLU D OE2 1 
ATOM   7725 N  N   . HIS D 2 126 ? -26.886 -7.032  38.125  1    30.54  ? 296 HIS D N   1 
ATOM   7726 C  CA  . HIS D 2 126 ? -26.269 -6.238  37.072  1    33.39  ? 296 HIS D CA  1 
ATOM   7727 C  C   . HIS D 2 126 ? -26.017 -7.116  35.841  1    33.44  ? 296 HIS D C   1 
ATOM   7728 O  O   . HIS D 2 126 ? -26.315 -6.694  34.726  1    33.37  ? 296 HIS D O   1 
ATOM   7729 C  CB  . HIS D 2 126 ? -25.022 -5.477  37.56   1    30.03  ? 296 HIS D CB  1 
ATOM   7730 C  CG  . HIS D 2 126 ? -24.691 -4.259  36.743  1    42.39  ? 296 HIS D CG  1 
ATOM   7731 N  ND1 . HIS D 2 126 ? -23.639 -3.417  37.026  1    44.32  ? 296 HIS D ND1 1 
ATOM   7732 C  CD2 . HIS D 2 126 ? -25.263 -3.731  35.626  1    46.45  ? 296 HIS D CD2 1 
ATOM   7733 C  CE1 . HIS D 2 126 ? -23.589 -2.449  36.111  1    44.42  ? 296 HIS D CE1 1 
ATOM   7734 N  NE2 . HIS D 2 126 ? -24.576 -2.6    35.268  1    42.79  ? 296 HIS D NE2 1 
ATOM   7735 N  N   . LEU D 2 127 ? -25.489 -8.335  36.029  1    31.3   ? 297 LEU D N   1 
ATOM   7736 C  CA  . LEU D 2 127 ? -25.214 -9.198  34.884  1    30.73  ? 297 LEU D CA  1 
ATOM   7737 C  C   . LEU D 2 127 ? -26.505 -9.471  34.118  1    30.35  ? 297 LEU D C   1 
ATOM   7738 O  O   . LEU D 2 127 ? -26.506 -9.54   32.901  1    30.97  ? 297 LEU D O   1 
ATOM   7739 C  CB  . LEU D 2 127 ? -24.55  -10.521 35.259  1    26.28  ? 297 LEU D CB  1 
ATOM   7740 C  CG  . LEU D 2 127 ? -24.149 -11.385 34.05   1    29.18  ? 297 LEU D CG  1 
ATOM   7741 C  CD1 . LEU D 2 127 ? -23.139 -10.684 33.126  1    23.69  ? 297 LEU D CD1 1 
ATOM   7742 C  CD2 . LEU D 2 127 ? -23.583 -12.722 34.493  1    27.09  ? 297 LEU D CD2 1 
ATOM   7743 N  N   . VAL D 2 128 ? -27.612 -9.643  34.847  1    32.3   ? 298 VAL D N   1 
ATOM   7744 C  CA  . VAL D 2 128 ? -28.848 -10.029 34.199  1    30.31  ? 298 VAL D CA  1 
ATOM   7745 C  C   . VAL D 2 128 ? -29.355 -8.873  33.352  1    33.55  ? 298 VAL D C   1 
ATOM   7746 O  O   . VAL D 2 128 ? -29.769 -9.118  32.216  1    32.75  ? 298 VAL D O   1 
ATOM   7747 C  CB  . VAL D 2 128 ? -29.885 -10.551 35.194  1    28.37  ? 298 VAL D CB  1 
ATOM   7748 C  CG1 . VAL D 2 128 ? -31.283 -10.649 34.559  1    25.29  ? 298 VAL D CG1 1 
ATOM   7749 C  CG2 . VAL D 2 128 ? -29.403 -11.88  35.761  1    23.02  ? 298 VAL D CG2 1 
ATOM   7750 N  N   . LEU D 2 129 ? -29.234 -7.643  33.892  1    30.38  ? 299 LEU D N   1 
ATOM   7751 C  CA  . LEU D 2 129 ? -29.635 -6.449  33.176  1    30.46  ? 299 LEU D CA  1 
ATOM   7752 C  C   . LEU D 2 129 ? -28.847 -6.296  31.874  1    34.5   ? 299 LEU D C   1 
ATOM   7753 O  O   . LEU D 2 129 ? -29.434 -5.971  30.836  1    32.93  ? 299 LEU D O   1 
ATOM   7754 C  CB  . LEU D 2 129 ? -29.509 -5.227  34.073  1    31.92  ? 299 LEU D CB  1 
ATOM   7755 C  CG  . LEU D 2 129 ? -30.582 -5.06   35.153  1    34.63  ? 299 LEU D CG  1 
ATOM   7756 C  CD1 . LEU D 2 129 ? -30.196 -3.916  36.083  1    30.96  ? 299 LEU D CD1 1 
ATOM   7757 C  CD2 . LEU D 2 129 ? -31.981 -4.829  34.562  1    33.06  ? 299 LEU D CD2 1 
ATOM   7758 N  N   . LYS D 2 130 ? -27.539 -6.571  31.928  1    32.24  ? 300 LYS D N   1 
ATOM   7759 C  CA  . LYS D 2 130 ? -26.671 -6.429  30.768  1    36.23  ? 300 LYS D CA  1 
ATOM   7760 C  C   . LYS D 2 130 ? -27.075 -7.443  29.699  1    37.44  ? 300 LYS D C   1 
ATOM   7761 O  O   . LYS D 2 130 ? -27.188 -7.11   28.513  1    34.55  ? 300 LYS D O   1 
ATOM   7762 C  CB  . LYS D 2 130 ? -25.188 -6.64   31.117  1    43.98  ? 300 LYS D CB  1 
ATOM   7763 C  CG  . LYS D 2 130 ? -24.516 -5.464  31.817  1    46.06  ? 300 LYS D CG  1 
ATOM   7764 C  CD  . LYS D 2 130 ? -23.179 -5.759  32.483  1    57.28  ? 300 LYS D CD  1 
ATOM   7765 C  CE  . LYS D 2 130 ? -22.387 -4.506  32.73   1    66.27  ? 300 LYS D CE  1 
ATOM   7766 N  NZ  . LYS D 2 130 ? -21.339 -4.65   33.75   1    74.12  ? 300 LYS D NZ  1 
ATOM   7767 N  N   . VAL D 2 131 ? -27.285 -8.685  30.139  1    32.97  ? 301 VAL D N   1 
ATOM   7768 C  CA  . VAL D 2 131 ? -27.586 -9.775  29.232  1    32.86  ? 301 VAL D CA  1 
ATOM   7769 C  C   . VAL D 2 131 ? -28.939 -9.509  28.588  1    36.51  ? 301 VAL D C   1 
ATOM   7770 O  O   . VAL D 2 131 ? -29.112 -9.799  27.423  1    37.03  ? 301 VAL D O   1 
ATOM   7771 C  CB  . VAL D 2 131 ? -27.566 -11.129 29.96   1    31.27  ? 301 VAL D CB  1 
ATOM   7772 C  CG1 . VAL D 2 131 ? -28.347 -12.221 29.235  1    26.83  ? 301 VAL D CG1 1 
ATOM   7773 C  CG2 . VAL D 2 131 ? -26.139 -11.561 30.23   1    30.02  ? 301 VAL D CG2 1 
ATOM   7774 N  N   . LEU D 2 132 ? -29.892 -8.967  29.351  1    40.86  ? 302 LEU D N   1 
ATOM   7775 C  CA  . LEU D 2 132 ? -31.224 -8.707  28.827  1    37.41  ? 302 LEU D CA  1 
ATOM   7776 C  C   . LEU D 2 132 ? -31.262 -7.328  28.189  1    38.34  ? 302 LEU D C   1 
ATOM   7777 O  O   . LEU D 2 132 ? -32.267 -6.954  27.622  1    37.64  ? 302 LEU D O   1 
ATOM   7778 C  CB  . LEU D 2 132 ? -32.25  -8.83   29.947  1    31.65  ? 302 LEU D CB  1 
ATOM   7779 C  CG  . LEU D 2 132 ? -32.406 -10.253 30.489  1    33.12  ? 302 LEU D CG  1 
ATOM   7780 C  CD1 . LEU D 2 132 ? -33.448 -10.287 31.57   1    29.76  ? 302 LEU D CD1 1 
ATOM   7781 C  CD2 . LEU D 2 132 ? -32.813 -11.184 29.358  1    35.16  ? 302 LEU D CD2 1 
ATOM   7782 N  N   . ALA D 2 133 ? -30.172 -6.567  28.307  1    42.13  ? 303 ALA D N   1 
ATOM   7783 C  CA  . ALA D 2 133 ? -30.133 -5.227  27.737  1    42.13  ? 303 ALA D CA  1 
ATOM   7784 C  C   . ALA D 2 133 ? -31.25  -4.339  28.297  1    36.33  ? 303 ALA D C   1 
ATOM   7785 O  O   . ALA D 2 133 ? -31.738 -3.481  27.577  1    34.26  ? 303 ALA D O   1 
ATOM   7786 C  CB  . ALA D 2 133 ? -30.175 -5.307  26.221  1    34.32  ? 303 ALA D CB  1 
ATOM   7787 N  N   . PHE D 2 134 ? -31.667 -4.582  29.552  1    32.34  ? 304 PHE D N   1 
ATOM   7788 C  CA  . PHE D 2 134 ? -32.725 -3.834  30.22   1    34.32  ? 304 PHE D CA  1 
ATOM   7789 C  C   . PHE D 2 134 ? -34.091 -4.032  29.56   1    35.21  ? 304 PHE D C   1 
ATOM   7790 O  O   . PHE D 2 134 ? -34.988 -3.221  29.751  1    35.6   ? 304 PHE D O   1 
ATOM   7791 C  CB  . PHE D 2 134 ? -32.387 -2.346  30.336  1    35.05  ? 304 PHE D CB  1 
ATOM   7792 C  CG  . PHE D 2 134 ? -31.46  -1.923  31.464  1    39.28  ? 304 PHE D CG  1 
ATOM   7793 C  CD1 . PHE D 2 134 ? -31.985 -1.56   32.707  1    36.15  ? 304 PHE D CD1 1 
ATOM   7794 C  CD2 . PHE D 2 134 ? -30.078 -1.843  31.271  1    36.71  ? 304 PHE D CD2 1 
ATOM   7795 C  CE1 . PHE D 2 134 ? -31.151 -1.147  33.741  1    32.5   ? 304 PHE D CE1 1 
ATOM   7796 C  CE2 . PHE D 2 134 ? -29.25  -1.424  32.312  1    39.6   ? 304 PHE D CE2 1 
ATOM   7797 C  CZ  . PHE D 2 134 ? -29.79  -1.059  33.537  1    37.1   ? 304 PHE D CZ  1 
ATOM   7798 N  N   . ASP D 2 135 ? -34.272 -5.113  28.788  1    42.99  ? 305 ASP D N   1 
ATOM   7799 C  CA  . ASP D 2 135 ? -35.567 -5.431  28.184  1    40.73  ? 305 ASP D CA  1 
ATOM   7800 C  C   . ASP D 2 135 ? -36.421 -6.191  29.19   1    37.25  ? 305 ASP D C   1 
ATOM   7801 O  O   . ASP D 2 135 ? -36.513 -7.428  29.13   1    34.98  ? 305 ASP D O   1 
ATOM   7802 C  CB  . ASP D 2 135 ? -35.423 -6.276  26.94   1    44.6   ? 305 ASP D CB  1 
ATOM   7803 C  CG  . ASP D 2 135 ? -34.846 -5.549  25.747  1    62.36  ? 305 ASP D CG  1 
ATOM   7804 O  OD1 . ASP D 2 135 ? -34.802 -4.285  25.768  1    56.26  ? 305 ASP D OD1 1 
ATOM   7805 O  OD2 . ASP D 2 135 ? -34.43  -6.28   24.836  1    84.8   ? 305 ASP D OD2 1 
ATOM   7806 N  N   . LEU D 2 136 ? -37.005 -5.442  30.138  1    30.47  ? 306 LEU D N   1 
ATOM   7807 C  CA  . LEU D 2 136 ? -37.663 -6.1    31.245  1    33.28  ? 306 LEU D CA  1 
ATOM   7808 C  C   . LEU D 2 136 ? -39.172 -6.138  31.051  1    32.44  ? 306 LEU D C   1 
ATOM   7809 O  O   . LEU D 2 136 ? -39.835 -6.908  31.745  1    30.99  ? 306 LEU D O   1 
ATOM   7810 C  CB  . LEU D 2 136 ? -37.272 -5.429  32.555  1    40.31  ? 306 LEU D CB  1 
ATOM   7811 C  CG  . LEU D 2 136 ? -35.811 -5.559  32.992  1    48.21  ? 306 LEU D CG  1 
ATOM   7812 C  CD1 . LEU D 2 136 ? -35.796 -5.613  34.503  1    57.76  ? 306 LEU D CD1 1 
ATOM   7813 C  CD2 . LEU D 2 136 ? -35.044 -6.741  32.418  1    46.16  ? 306 LEU D CD2 1 
ATOM   7814 N  N   . ALA D 2 137 ? -39.702 -5.321  30.122  1    30.84  ? 307 ALA D N   1 
ATOM   7815 C  CA  . ALA D 2 137 ? -41.147 -5.164  29.996  1    31.83  ? 307 ALA D CA  1 
ATOM   7816 C  C   . ALA D 2 137 ? -41.689 -6.232  29.07   1    33.62  ? 307 ALA D C   1 
ATOM   7817 O  O   . ALA D 2 137 ? -42.28  -5.905  28.039  1    40.09  ? 307 ALA D O   1 
ATOM   7818 C  CB  . ALA D 2 137 ? -41.535 -3.781  29.516  1    29.57  ? 307 ALA D CB  1 
ATOM   7819 N  N   . ALA D 2 138 ? -41.504 -7.489  29.479  1    33.73  ? 308 ALA D N   1 
ATOM   7820 C  CA  . ALA D 2 138 ? -41.874 -8.653  28.688  1    33.91  ? 308 ALA D CA  1 
ATOM   7821 C  C   . ALA D 2 138 ? -43.368 -8.94   28.819  1    35.94  ? 308 ALA D C   1 
ATOM   7822 O  O   . ALA D 2 138 ? -43.933 -8.887  29.915  1    38.25  ? 308 ALA D O   1 
ATOM   7823 C  CB  . ALA D 2 138 ? -41.05  -9.847  29.109  1    27.62  ? 308 ALA D CB  1 
ATOM   7824 N  N   . PRO D 2 139 ? -44.061 -9.276  27.708  1    36.27  ? 309 PRO D N   1 
ATOM   7825 C  CA  . PRO D 2 139 ? -45.402 -9.854  27.805  1    37.78  ? 309 PRO D CA  1 
ATOM   7826 C  C   . PRO D 2 139 ? -45.364 -11.214 28.52   1    39.65  ? 309 PRO D C   1 
ATOM   7827 O  O   . PRO D 2 139 ? -44.432 -12.014 28.307  1    35.59  ? 309 PRO D O   1 
ATOM   7828 C  CB  . PRO D 2 139 ? -45.865 -9.964  26.337  1    33.65  ? 309 PRO D CB  1 
ATOM   7829 C  CG  . PRO D 2 139 ? -44.934 -9.072  25.561  1    31.48  ? 309 PRO D CG  1 
ATOM   7830 C  CD  . PRO D 2 139 ? -43.606 -9.116  26.319  1    34.3   ? 309 PRO D CD  1 
ATOM   7831 N  N   . THR D 2 140 ? -46.388 -11.439 29.375  1    36.05  ? 310 THR D N   1 
ATOM   7832 C  CA  . THR D 2 140 ? -46.567 -12.669 30.145  1    37.39  ? 310 THR D CA  1 
ATOM   7833 C  C   . THR D 2 140 ? -47.876 -13.361 29.774  1    38.03  ? 310 THR D C   1 
ATOM   7834 O  O   . THR D 2 140 ? -48.752 -12.766 29.138  1    41.26  ? 310 THR D O   1 
ATOM   7835 C  CB  . THR D 2 140 ? -46.521 -12.409 31.65   1    33.59  ? 310 THR D CB  1 
ATOM   7836 O  OG1 . THR D 2 140 ? -47.614 -11.577 32.025  1    29.38  ? 310 THR D OG1 1 
ATOM   7837 C  CG2 . THR D 2 140 ? -45.225 -11.75  32.079  1    36.49  ? 310 THR D CG2 1 
ATOM   7838 N  N   . ILE D 2 141 ? -48.008 -14.61  30.236  1    37.28  ? 311 ILE D N   1 
ATOM   7839 C  CA  . ILE D 2 141 ? -49.251 -15.372 30.153  1    39.22  ? 311 ILE D CA  1 
ATOM   7840 C  C   . ILE D 2 141 ? -50.372 -14.629 30.887  1    43.75  ? 311 ILE D C   1 
ATOM   7841 O  O   . ILE D 2 141 ? -51.505 -14.575 30.389  1    43.54  ? 311 ILE D O   1 
ATOM   7842 C  CB  . ILE D 2 141 ? -49.036 -16.796 30.701  1    33.63  ? 311 ILE D CB  1 
ATOM   7843 C  CG1 . ILE D 2 141 ? -48.175 -17.621 29.754  1    30.01  ? 311 ILE D CG1 1 
ATOM   7844 C  CG2 . ILE D 2 141 ? -50.366 -17.48  31.036  1    29.53  ? 311 ILE D CG2 1 
ATOM   7845 C  CD1 . ILE D 2 141 ? -47.585 -18.863 30.402  1    34.86  ? 311 ILE D CD1 1 
ATOM   7846 N  N   . ASN D 2 142 ? -50.048 -14.055 32.06   1    39.67  ? 312 ASN D N   1 
ATOM   7847 C  CA  . ASN D 2 142 ? -51.024 -13.294 32.818  1    41.62  ? 312 ASN D CA  1 
ATOM   7848 C  C   . ASN D 2 142 ? -51.539 -12.115 32.008  1    41.01  ? 312 ASN D C   1 
ATOM   7849 O  O   . ASN D 2 142 ? -52.741 -11.863 32.053  1    43.28  ? 312 ASN D O   1 
ATOM   7850 C  CB  . ASN D 2 142 ? -50.487 -12.764 34.141  1    46.12  ? 312 ASN D CB  1 
ATOM   7851 C  CG  . ASN D 2 142 ? -50.939 -13.594 35.316  1    57.77  ? 312 ASN D CG  1 
ATOM   7852 O  OD1 . ASN D 2 142 ? -50.856 -14.831 35.288  1    74.42  ? 312 ASN D OD1 1 
ATOM   7853 N  ND2 . ASN D 2 142 ? -51.442 -12.92  36.34   1    58.31  ? 312 ASN D ND2 1 
ATOM   7854 N  N   . GLN D 2 143 ? -50.638 -11.385 31.319  1    37.98  ? 313 GLN D N   1 
ATOM   7855 C  CA  . GLN D 2 143 ? -51.022 -10.156 30.624  1    39.33  ? 313 GLN D CA  1 
ATOM   7856 C  C   . GLN D 2 143 ? -52.071 -10.453 29.552  1    38.56  ? 313 GLN D C   1 
ATOM   7857 O  O   . GLN D 2 143 ? -52.874 -9.588  29.215  1    41.98  ? 313 GLN D O   1 
ATOM   7858 C  CB  . GLN D 2 143 ? -49.857 -9.434  29.959  1    35.55  ? 313 GLN D CB  1 
ATOM   7859 C  CG  . GLN D 2 143 ? -48.985 -8.641  30.919  1    39.14  ? 313 GLN D CG  1 
ATOM   7860 C  CD  . GLN D 2 143 ? -47.8   -8.009  30.223  1    45.22  ? 313 GLN D CD  1 
ATOM   7861 O  OE1 . GLN D 2 143 ? -47.955 -7.147  29.339  1    47.41  ? 313 GLN D OE1 1 
ATOM   7862 N  NE2 . GLN D 2 143 ? -46.605 -8.446  30.61   1    40.68  ? 313 GLN D NE2 1 
ATOM   7863 N  N   . PHE D 2 144 ? -52.024 -11.674 29.009  1    34.15  ? 314 PHE D N   1 
ATOM   7864 C  CA  . PHE D 2 144 ? -53.039 -12.125 28.076  1    36.19  ? 314 PHE D CA  1 
ATOM   7865 C  C   . PHE D 2 144 ? -54.27  -12.639 28.825  1    35.81  ? 314 PHE D C   1 
ATOM   7866 O  O   . PHE D 2 144 ? -55.393 -12.317 28.429  1    34.11  ? 314 PHE D O   1 
ATOM   7867 C  CB  . PHE D 2 144 ? -52.466 -13.131 27.085  1    33.07  ? 314 PHE D CB  1 
ATOM   7868 C  CG  . PHE D 2 144 ? -51.524 -12.485 26.092  1    29.67  ? 314 PHE D CG  1 
ATOM   7869 C  CD1 . PHE D 2 144 ? -52.025 -11.737 25.034  1    31.86  ? 314 PHE D CD1 1 
ATOM   7870 C  CD2 . PHE D 2 144 ? -50.153 -12.624 26.231  1    26.8   ? 314 PHE D CD2 1 
ATOM   7871 C  CE1 . PHE D 2 144 ? -51.155 -11.158 24.115  1    35.46  ? 314 PHE D CE1 1 
ATOM   7872 C  CE2 . PHE D 2 144 ? -49.291 -12.036 25.319  1    31.33  ? 314 PHE D CE2 1 
ATOM   7873 C  CZ  . PHE D 2 144 ? -49.786 -11.301 24.26   1    33.11  ? 314 PHE D CZ  1 
ATOM   7874 N  N   . LEU D 2 145 ? -54.058 -13.398 29.908  1    34.99  ? 315 LEU D N   1 
ATOM   7875 C  CA  . LEU D 2 145 ? -55.168 -13.908 30.705  1    35.13  ? 315 LEU D CA  1 
ATOM   7876 C  C   . LEU D 2 145 ? -56.098 -12.776 31.149  1    36.56  ? 315 LEU D C   1 
ATOM   7877 O  O   . LEU D 2 145 ? -57.319 -12.904 30.998  1    41.92  ? 315 LEU D O   1 
ATOM   7878 C  CB  . LEU D 2 145 ? -54.702 -14.732 31.906  1    33.6   ? 315 LEU D CB  1 
ATOM   7879 C  CG  . LEU D 2 145 ? -54.249 -16.166 31.635  1    32.44  ? 315 LEU D CG  1 
ATOM   7880 C  CD1 . LEU D 2 145 ? -53.762 -16.777 32.942  1    34.49  ? 315 LEU D CD1 1 
ATOM   7881 C  CD2 . LEU D 2 145 ? -55.333 -16.998 31.014  1    30.48  ? 315 LEU D CD2 1 
ATOM   7882 N  N   . THR D 2 146 ? -55.535 -11.709 31.739  1    31.96  ? 316 THR D N   1 
ATOM   7883 C  CA  . THR D 2 146 ? -56.363 -10.709 32.402  1    32.93  ? 316 THR D CA  1 
ATOM   7884 C  C   . THR D 2 146 ? -57.25  -10.051 31.35   1    34.27  ? 316 THR D C   1 
ATOM   7885 O  O   . THR D 2 146 ? -58.396 -9.696  31.656  1    34.82  ? 316 THR D O   1 
ATOM   7886 C  CB  . THR D 2 146 ? -55.585 -9.671  33.225  1    33.9   ? 316 THR D CB  1 
ATOM   7887 O  OG1 . THR D 2 146 ? -54.784 -8.902  32.338  1    36.64  ? 316 THR D OG1 1 
ATOM   7888 C  CG2 . THR D 2 146 ? -54.704 -10.239 34.326  1    28.97  ? 316 THR D CG2 1 
ATOM   7889 N  N   . GLN D 2 147 ? -56.704 -9.914  30.123  1    32.98  ? 317 GLN D N   1 
ATOM   7890 C  CA  . GLN D 2 147 ? -57.407 -9.37   28.964  1    35.81  ? 317 GLN D CA  1 
ATOM   7891 C  C   . GLN D 2 147 ? -58.539 -10.31  28.522  1    38.62  ? 317 GLN D C   1 
ATOM   7892 O  O   . GLN D 2 147 ? -59.653 -9.86   28.213  1    35.57  ? 317 GLN D O   1 
ATOM   7893 C  CB  . GLN D 2 147 ? -56.466 -9.169  27.771  1    35.63  ? 317 GLN D CB  1 
ATOM   7894 C  CG  . GLN D 2 147 ? -55.53  -7.965  27.835  1    38.85  ? 317 GLN D CG  1 
ATOM   7895 C  CD  . GLN D 2 147 ? -54.763 -7.772  26.542  1    41.51  ? 317 GLN D CD  1 
ATOM   7896 O  OE1 . GLN D 2 147 ? -53.58  -8.107  26.45   1    49.16  ? 317 GLN D OE1 1 
ATOM   7897 N  NE2 . GLN D 2 147 ? -55.429 -7.298  25.497  1    44.39  ? 317 GLN D NE2 1 
ATOM   7898 N  N   . TYR D 2 148 ? -58.229 -11.616 28.442  1    35.87  ? 318 TYR D N   1 
ATOM   7899 C  CA  . TYR D 2 148 ? -59.185 -12.605 27.978  1    34.74  ? 318 TYR D CA  1 
ATOM   7900 C  C   . TYR D 2 148 ? -60.362 -12.692 28.955  1    39.12  ? 318 TYR D C   1 
ATOM   7901 O  O   . TYR D 2 148 ? -61.495 -12.937 28.532  1    36.97  ? 318 TYR D O   1 
ATOM   7902 C  CB  . TYR D 2 148 ? -58.561 -13.987 27.808  1    29.97  ? 318 TYR D CB  1 
ATOM   7903 C  CG  . TYR D 2 148 ? -57.467 -14.157 26.768  1    28.92  ? 318 TYR D CG  1 
ATOM   7904 C  CD1 . TYR D 2 148 ? -57.291 -13.268 25.716  1    27.91  ? 318 TYR D CD1 1 
ATOM   7905 C  CD2 . TYR D 2 148 ? -56.601 -15.244 26.853  1    27.42  ? 318 TYR D CD2 1 
ATOM   7906 C  CE1 . TYR D 2 148 ? -56.266 -13.462 24.798  1    29.2   ? 318 TYR D CE1 1 
ATOM   7907 C  CE2 . TYR D 2 148 ? -55.589 -15.452 25.936  1    25.91  ? 318 TYR D CE2 1 
ATOM   7908 C  CZ  . TYR D 2 148 ? -55.409 -14.551 24.91   1    28.33  ? 318 TYR D CZ  1 
ATOM   7909 O  OH  . TYR D 2 148 ? -54.375 -14.788 24.048  1    30.57  ? 318 TYR D OH  1 
ATOM   7910 N  N   . PHE D 2 149 ? -60.09  -12.463 30.251  1    37.73  ? 319 PHE D N   1 
ATOM   7911 C  CA  . PHE D 2 149 ? -61.093 -12.607 31.294  1    41.8   ? 319 PHE D CA  1 
ATOM   7912 C  C   . PHE D 2 149 ? -62.216 -11.59  31.128  1    45.85  ? 319 PHE D C   1 
ATOM   7913 O  O   . PHE D 2 149 ? -63.303 -11.799 31.665  1    43.45  ? 319 PHE D O   1 
ATOM   7914 C  CB  . PHE D 2 149 ? -60.499 -12.374 32.678  1    45.57  ? 319 PHE D CB  1 
ATOM   7915 C  CG  . PHE D 2 149 ? -59.534 -13.444 33.16   1    50.42  ? 319 PHE D CG  1 
ATOM   7916 C  CD1 . PHE D 2 149 ? -59.466 -14.688 32.531  1    49.99  ? 319 PHE D CD1 1 
ATOM   7917 C  CD2 . PHE D 2 149 ? -58.723 -13.2   34.265  1    48.8   ? 319 PHE D CD2 1 
ATOM   7918 C  CE1 . PHE D 2 149 ? -58.595 -15.657 32.998  1    49.92  ? 319 PHE D CE1 1 
ATOM   7919 C  CE2 . PHE D 2 149 ? -57.861 -14.176 34.732  1    52.13  ? 319 PHE D CE2 1 
ATOM   7920 C  CZ  . PHE D 2 149 ? -57.793 -15.398 34.093  1    49.79  ? 319 PHE D CZ  1 
ATOM   7921 N  N   . LEU D 2 150 ? -61.928 -10.506 30.393  1    44.78  ? 320 LEU D N   1 
ATOM   7922 C  CA  . LEU D 2 150 ? -62.895 -9.459  30.097  1    43.35  ? 320 LEU D CA  1 
ATOM   7923 C  C   . LEU D 2 150 ? -63.961 -9.949  29.114  1    42.25  ? 320 LEU D C   1 
ATOM   7924 O  O   . LEU D 2 150 ? -65.017 -9.333  29.011  1    46.61  ? 320 LEU D O   1 
ATOM   7925 C  CB  . LEU D 2 150 ? -62.201 -8.216  29.536  1    41.94  ? 320 LEU D CB  1 
ATOM   7926 C  CG  . LEU D 2 150 ? -61.213 -7.477  30.444  1    41.58  ? 320 LEU D CG  1 
ATOM   7927 C  CD1 . LEU D 2 150 ? -60.953 -6.093  29.853  1    36.33  ? 320 LEU D CD1 1 
ATOM   7928 C  CD2 . LEU D 2 150 ? -61.694 -7.411  31.895  1    41.91  ? 320 LEU D CD2 1 
ATOM   7929 N  N   . HIS D 2 151 ? -63.685 -11.023 28.372  1    41.34  ? 321 HIS D N   1 
ATOM   7930 C  CA  . HIS D 2 151 ? -64.65  -11.491 27.394  1    43.66  ? 321 HIS D CA  1 
ATOM   7931 C  C   . HIS D 2 151 ? -65.617 -12.483 28.029  1    45.16  ? 321 HIS D C   1 
ATOM   7932 O  O   . HIS D 2 151 ? -66.589 -12.859 27.381  1    52.56  ? 321 HIS D O   1 
ATOM   7933 C  CB  . HIS D 2 151 ? -63.971 -12.07  26.151  1    47.33  ? 321 HIS D CB  1 
ATOM   7934 C  CG  . HIS D 2 151 ? -63.381 -11.055 25.231  1    52.14  ? 321 HIS D CG  1 
ATOM   7935 N  ND1 . HIS D 2 151 ? -63.77  -10.956 23.911  1    57.66  ? 321 HIS D ND1 1 
ATOM   7936 C  CD2 . HIS D 2 151 ? -62.469 -10.096 25.421  1    52.18  ? 321 HIS D CD2 1 
ATOM   7937 C  CE1 . HIS D 2 151 ? -63.09  -9.981  23.323  1    55.68  ? 321 HIS D CE1 1 
ATOM   7938 N  NE2 . HIS D 2 151 ? -62.292 -9.446  24.223  1    51.22  ? 321 HIS D NE2 1 
ATOM   7939 N  N   . GLN D 2 152 ? -65.352 -12.892 29.28   1    43.6   ? 322 GLN D N   1 
ATOM   7940 C  CA  . GLN D 2 152 ? -66.291 -13.717 30.024  1    48.15  ? 322 GLN D CA  1 
ATOM   7941 C  C   . GLN D 2 152 ? -67.66  -13.047 30.056  1    56.51  ? 322 GLN D C   1 
ATOM   7942 O  O   . GLN D 2 152 ? -67.764 -11.839 29.862  1    56.51  ? 322 GLN D O   1 
ATOM   7943 C  CB  . GLN D 2 152 ? -65.892 -13.878 31.48   1    47.45  ? 322 GLN D CB  1 
ATOM   7944 C  CG  . GLN D 2 152 ? -64.798 -14.907 31.711  1    52.39  ? 322 GLN D CG  1 
ATOM   7945 C  CD  . GLN D 2 152 ? -64.507 -15.056 33.184  1    53.59  ? 322 GLN D CD  1 
ATOM   7946 O  OE1 . GLN D 2 152 ? -64.855 -16.077 33.785  1    60.13  ? 322 GLN D OE1 1 
ATOM   7947 N  NE2 . GLN D 2 152 ? -63.927 -14.017 33.775  1    43.25  ? 322 GLN D NE2 1 
ATOM   7948 N  N   . GLN D 2 153 ? -68.691 -13.849 30.363  1    65.93  ? 323 GLN D N   1 
ATOM   7949 C  CA  . GLN D 2 153 ? -70.081 -13.447 30.198  1    72.82  ? 323 GLN D CA  1 
ATOM   7950 C  C   . GLN D 2 153 ? -70.99  -14.309 31.08   1    68.87  ? 323 GLN D C   1 
ATOM   7951 O  O   . GLN D 2 153 ? -71.533 -15.312 30.613  1    65.38  ? 323 GLN D O   1 
ATOM   7952 C  CB  . GLN D 2 153 ? -70.41  -13.641 28.716  1    79.76  ? 323 GLN D CB  1 
ATOM   7953 C  CG  . GLN D 2 153 ? -71.685 -12.956 28.239  1    80.78  ? 323 GLN D CG  1 
ATOM   7954 C  CD  . GLN D 2 153 ? -71.689 -11.473 28.525  1    73.51  ? 323 GLN D CD  1 
ATOM   7955 O  OE1 . GLN D 2 153 ? -70.646 -10.813 28.512  1    66.7   ? 323 GLN D OE1 1 
ATOM   7956 N  NE2 . GLN D 2 153 ? -72.869 -10.942 28.803  1    72.63  ? 323 GLN D NE2 1 
ATOM   7957 N  N   . PRO D 2 154 ? -71.183 -13.98  32.384  1    64.14  ? 324 PRO D N   1 
ATOM   7958 C  CA  . PRO D 2 154 ? -70.489 -12.865 33.042  1    62.37  ? 324 PRO D CA  1 
ATOM   7959 C  C   . PRO D 2 154 ? -69.132 -13.316 33.586  1    64.64  ? 324 PRO D C   1 
ATOM   7960 O  O   . PRO D 2 154 ? -68.694 -14.432 33.31   1    67.73  ? 324 PRO D O   1 
ATOM   7961 C  CB  . PRO D 2 154 ? -71.473 -12.514 34.165  1    57.9   ? 324 PRO D CB  1 
ATOM   7962 C  CG  . PRO D 2 154 ? -72.058 -13.859 34.563  1    59.45  ? 324 PRO D CG  1 
ATOM   7963 C  CD  . PRO D 2 154 ? -72.093 -14.699 33.295  1    59.36  ? 324 PRO D CD  1 
ATOM   7964 N  N   . ALA D 2 155 ? -68.467 -12.443 34.356  1    59.72  ? 325 ALA D N   1 
ATOM   7965 C  CA  . ALA D 2 155 ? -67.242 -12.803 35.05   1    50.51  ? 325 ALA D CA  1 
ATOM   7966 C  C   . ALA D 2 155 ? -67.503 -13.98  35.996  1    50.83  ? 325 ALA D C   1 
ATOM   7967 O  O   . ALA D 2 155 ? -68.593 -14.112 36.55   1    52.77  ? 325 ALA D O   1 
ATOM   7968 C  CB  . ALA D 2 155 ? -66.716 -11.591 35.774  1    44.12  ? 325 ALA D CB  1 
ATOM   7969 N  N   . ASN D 2 156 ? -66.502 -14.853 36.148  1    49.13  ? 326 ASN D N   1 
ATOM   7970 C  CA  . ASN D 2 156 ? -66.582 -16.03  37.002  1    49.36  ? 326 ASN D CA  1 
ATOM   7971 C  C   . ASN D 2 156 ? -65.272 -16.127 37.784  1    49.73  ? 326 ASN D C   1 
ATOM   7972 O  O   . ASN D 2 156 ? -64.207 -16.279 37.188  1    43.41  ? 326 ASN D O   1 
ATOM   7973 C  CB  . ASN D 2 156 ? -66.823 -17.29  36.169  1    51.07  ? 326 ASN D CB  1 
ATOM   7974 C  CG  . ASN D 2 156 ? -67.132 -18.54  36.965  1    50.56  ? 326 ASN D CG  1 
ATOM   7975 O  OD1 . ASN D 2 156 ? -66.34  -18.98  37.805  1    48.59  ? 326 ASN D OD1 1 
ATOM   7976 N  ND2 . ASN D 2 156 ? -68.263 -19.16  36.674  1    54.32  ? 326 ASN D ND2 1 
ATOM   7977 N  N   . CYS D 2 157 ? -65.356 -16.049 39.12   1    54.02  ? 327 CYS D N   1 
ATOM   7978 C  CA  . CYS D 2 157 ? -64.178 -16.027 39.979  1    55.06  ? 327 CYS D CA  1 
ATOM   7979 C  C   . CYS D 2 157 ? -63.389 -17.321 39.83   1    51.18  ? 327 CYS D C   1 
ATOM   7980 O  O   . CYS D 2 157 ? -62.174 -17.309 39.99   1    43.85  ? 327 CYS D O   1 
ATOM   7981 C  CB  . CYS D 2 157 ? -64.547 -16.031 41.457  1    64.46  ? 327 CYS D CB  1 
ATOM   7982 S  SG  . CYS D 2 157 ? -65.926 -14.934 41.864  1    86.35  ? 327 CYS D SG  1 
ATOM   7983 N  N   . LYS D 2 158 ? -64.102 -18.424 39.552  1    53.04  ? 328 LYS D N   1 
ATOM   7984 C  CA  . LYS D 2 158 ? -63.534 -19.765 39.6    1    53.14  ? 328 LYS D CA  1 
ATOM   7985 C  C   . LYS D 2 158 ? -62.798 -20.063 38.288  1    55.2   ? 328 LYS D C   1 
ATOM   7986 O  O   . LYS D 2 158 ? -61.707 -20.643 38.297  1    55     ? 328 LYS D O   1 
ATOM   7987 C  CB  . LYS D 2 158 ? -64.646 -20.754 39.971  1    46.64  ? 328 LYS D CB  1 
ATOM   7988 C  CG  . LYS D 2 158 ? -64.298 -21.66  41.14   1    43.46  ? 328 LYS D CG  1 
ATOM   7989 C  CD  . LYS D 2 158 ? -65.578 -22.113 41.84   1    44.39  ? 328 LYS D CD  1 
ATOM   7990 C  CE  . LYS D 2 158 ? -65.365 -22.883 43.115  1    43.19  ? 328 LYS D CE  1 
ATOM   7991 N  NZ  . LYS D 2 158 ? -66.577 -23.651 43.442  1    39.27  ? 328 LYS D NZ  1 
ATOM   7992 N  N   . VAL D 2 159 ? -63.401 -19.639 37.167  1    48.74  ? 329 VAL D N   1 
ATOM   7993 C  CA  . VAL D 2 159 ? -62.773 -19.686 35.855  1    43.54  ? 329 VAL D CA  1 
ATOM   7994 C  C   . VAL D 2 159 ? -61.459 -18.89  35.883  1    41.9   ? 329 VAL D C   1 
ATOM   7995 O  O   . VAL D 2 159 ? -60.419 -19.398 35.467  1    39.83  ? 329 VAL D O   1 
ATOM   7996 C  CB  . VAL D 2 159 ? -63.76  -19.212 34.768  1    41.38  ? 329 VAL D CB  1 
ATOM   7997 C  CG1 . VAL D 2 159 ? -63.113 -19.031 33.407  1    41.99  ? 329 VAL D CG1 1 
ATOM   7998 C  CG2 . VAL D 2 159 ? -64.952 -20.145 34.64   1    44.02  ? 329 VAL D CG2 1 
ATOM   7999 N  N   . GLU D 2 160 ? -61.491 -17.665 36.426  1    43.21  ? 330 GLU D N   1 
ATOM   8000 C  CA  . GLU D 2 160 ? -60.303 -16.815 36.479  1    43.46  ? 330 GLU D CA  1 
ATOM   8001 C  C   . GLU D 2 160 ? -59.208 -17.505 37.287  1    41.01  ? 330 GLU D C   1 
ATOM   8002 O  O   . GLU D 2 160 ? -58.113 -17.717 36.772  1    41.17  ? 330 GLU D O   1 
ATOM   8003 C  CB  . GLU D 2 160 ? -60.602 -15.41  37.006  1    41.24  ? 330 GLU D CB  1 
ATOM   8004 C  CG  . GLU D 2 160 ? -61.375 -14.557 36.003  1    45.39  ? 330 GLU D CG  1 
ATOM   8005 C  CD  . GLU D 2 160 ? -61.894 -13.236 36.528  1    46.23  ? 330 GLU D CD  1 
ATOM   8006 O  OE1 . GLU D 2 160 ? -61.434 -12.883 37.617  1    51.09  ? 330 GLU D OE1 1 
ATOM   8007 O  OE2 . GLU D 2 160 ? -62.731 -12.588 35.857  1    46.48  ? 330 GLU D OE2 1 
ATOM   8008 N  N   . SER D 2 161 ? -59.532 -17.885 38.528  1    39.31  ? 331 SER D N   1 
ATOM   8009 C  CA  . SER D 2 161 ? -58.598 -18.585 39.396  1    44.37  ? 331 SER D CA  1 
ATOM   8010 C  C   . SER D 2 161 ? -58.039 -19.839 38.724  1    47.93  ? 331 SER D C   1 
ATOM   8011 O  O   . SER D 2 161 ? -56.841 -20.11  38.836  1    54.47  ? 331 SER D O   1 
ATOM   8012 C  CB  . SER D 2 161 ? -59.212 -18.913 40.73   1    42.97  ? 331 SER D CB  1 
ATOM   8013 O  OG  . SER D 2 161 ? -59.114 -17.805 41.611  1    49.42  ? 331 SER D OG  1 
ATOM   8014 N  N   . LEU D 2 162 ? -58.907 -20.608 38.058  1    41.21  ? 332 LEU D N   1 
ATOM   8015 C  CA  . LEU D 2 162 ? -58.48  -21.874 37.498  1    38.31  ? 332 LEU D CA  1 
ATOM   8016 C  C   . LEU D 2 162 ? -57.517 -21.636 36.339  1    35.73  ? 332 LEU D C   1 
ATOM   8017 O  O   . LEU D 2 162 ? -56.52  -22.342 36.227  1    39.66  ? 332 LEU D O   1 
ATOM   8018 C  CB  . LEU D 2 162 ? -59.666 -22.739 37.085  1    38.26  ? 332 LEU D CB  1 
ATOM   8019 C  CG  . LEU D 2 162 ? -59.311 -24.096 36.462  1    40.3   ? 332 LEU D CG  1 
ATOM   8020 C  CD1 . LEU D 2 162 ? -58.275 -24.832 37.308  1    42.74  ? 332 LEU D CD1 1 
ATOM   8021 C  CD2 . LEU D 2 162 ? -60.532 -24.989 36.252  1    40.03  ? 332 LEU D CD2 1 
ATOM   8022 N  N   . ALA D 2 163 ? -57.813 -20.665 35.469  1    33.77  ? 333 ALA D N   1 
ATOM   8023 C  CA  . ALA D 2 163 ? -56.934 -20.388 34.339  1    36.52  ? 333 ALA D CA  1 
ATOM   8024 C  C   . ALA D 2 163 ? -55.568 -19.869 34.809  1    37.13  ? 333 ALA D C   1 
ATOM   8025 O  O   . ALA D 2 163 ? -54.531 -20.264 34.272  1    36.48  ? 333 ALA D O   1 
ATOM   8026 C  CB  . ALA D 2 163 ? -57.606 -19.452 33.366  1    37.79  ? 333 ALA D CB  1 
ATOM   8027 N  N   . MET D 2 164 ? -55.568 -19.004 35.831  1    40.45  ? 334 MET D N   1 
ATOM   8028 C  CA  . MET D 2 164 ? -54.334 -18.528 36.448  1    46.76  ? 334 MET D CA  1 
ATOM   8029 C  C   . MET D 2 164 ? -53.471 -19.727 36.847  1    44.46  ? 334 MET D C   1 
ATOM   8030 O  O   . MET D 2 164 ? -52.247 -19.689 36.689  1    47.1   ? 334 MET D O   1 
ATOM   8031 C  CB  . MET D 2 164 ? -54.613 -17.699 37.714  1    55.34  ? 334 MET D CB  1 
ATOM   8032 C  CG  . MET D 2 164 ? -55.192 -16.31  37.498  1    57.64  ? 334 MET D CG  1 
ATOM   8033 S  SD  . MET D 2 164 ? -53.903 -15.101 37.141  1    89.41  ? 334 MET D SD  1 
ATOM   8034 C  CE  . MET D 2 164 ? -54.837 -13.571 37.31   1    85.08  ? 334 MET D CE  1 
ATOM   8035 N  N   . PHE D 2 165 ? -54.128 -20.778 37.368  1    37.51  ? 335 PHE D N   1 
ATOM   8036 C  CA  . PHE D 2 165 ? -53.466 -21.934 37.945  1    35     ? 335 PHE D CA  1 
ATOM   8037 C  C   . PHE D 2 165 ? -52.82  -22.787 36.862  1    34.51  ? 335 PHE D C   1 
ATOM   8038 O  O   . PHE D 2 165 ? -51.684 -23.213 37.021  1    31.64  ? 335 PHE D O   1 
ATOM   8039 C  CB  . PHE D 2 165 ? -54.464 -22.78  38.733  1    33.38  ? 335 PHE D CB  1 
ATOM   8040 C  CG  . PHE D 2 165 ? -54.033 -24.218 38.966  1    33.63  ? 335 PHE D CG  1 
ATOM   8041 C  CD1 . PHE D 2 165 ? -53.085 -24.528 39.938  1    34.24  ? 335 PHE D CD1 1 
ATOM   8042 C  CD2 . PHE D 2 165 ? -54.597 -25.261 38.228  1    33.39  ? 335 PHE D CD2 1 
ATOM   8043 C  CE1 . PHE D 2 165 ? -52.72  -25.851 40.164  1    38.64  ? 335 PHE D CE1 1 
ATOM   8044 C  CE2 . PHE D 2 165 ? -54.239 -26.583 38.462  1    31.8   ? 335 PHE D CE2 1 
ATOM   8045 C  CZ  . PHE D 2 165 ? -53.302 -26.884 39.425  1    34.73  ? 335 PHE D CZ  1 
ATOM   8046 N  N   . LEU D 2 166 ? -53.578 -23.083 35.801  1    37.52  ? 336 LEU D N   1 
ATOM   8047 C  CA  . LEU D 2 166 ? -53.068 -23.892 34.704  1    37.26  ? 336 LEU D CA  1 
ATOM   8048 C  C   . LEU D 2 166 ? -51.882 -23.162 34.092  1    39.47  ? 336 LEU D C   1 
ATOM   8049 O  O   . LEU D 2 166 ? -50.856 -23.776 33.792  1    43.81  ? 336 LEU D O   1 
ATOM   8050 C  CB  . LEU D 2 166 ? -54.158 -24.107 33.657  1    34.04  ? 336 LEU D CB  1 
ATOM   8051 C  CG  . LEU D 2 166 ? -55.393 -24.871 34.126  1    33.33  ? 336 LEU D CG  1 
ATOM   8052 C  CD1 . LEU D 2 166 ? -56.42  -24.939 33.007  1    36.44  ? 336 LEU D CD1 1 
ATOM   8053 C  CD2 . LEU D 2 166 ? -55.031 -26.266 34.57   1    35.01  ? 336 LEU D CD2 1 
ATOM   8054 N  N   . GLY D 2 167 ? -52.054 -21.841 33.92   1    37.21  ? 337 GLY D N   1 
ATOM   8055 C  CA  . GLY D 2 167 ? -51.035 -20.985 33.338  1    37.3   ? 337 GLY D CA  1 
ATOM   8056 C  C   . GLY D 2 167 ? -49.705 -21.141 34.071  1    39.19  ? 337 GLY D C   1 
ATOM   8057 O  O   . GLY D 2 167 ? -48.653 -21.241 33.441  1    41.37  ? 337 GLY D O   1 
ATOM   8058 N  N   . GLU D 2 168 ? -49.788 -21.199 35.408  1    37.29  ? 338 GLU D N   1 
ATOM   8059 C  CA  . GLU D 2 168 ? -48.625 -21.263 36.276  1    35.37  ? 338 GLU D CA  1 
ATOM   8060 C  C   . GLU D 2 168 ? -47.983 -22.646 36.193  1    38.45  ? 338 GLU D C   1 
ATOM   8061 O  O   . GLU D 2 168 ? -46.756 -22.761 36.283  1    39.68  ? 338 GLU D O   1 
ATOM   8062 C  CB  . GLU D 2 168 ? -49.091 -20.999 37.7    1    32.2   ? 338 GLU D CB  1 
ATOM   8063 C  CG  . GLU D 2 168 ? -48.173 -20.057 38.453  1    34.64  ? 338 GLU D CG  1 
ATOM   8064 C  CD  . GLU D 2 168 ? -48.927 -19.285 39.516  1    37.97  ? 338 GLU D CD  1 
ATOM   8065 O  OE1 . GLU D 2 168 ? -48.6   -19.523 40.71   1    38.26  ? 338 GLU D OE1 1 
ATOM   8066 O  OE2 . GLU D 2 168 ? -49.806 -18.45  39.15   1    36.79  ? 338 GLU D OE2 1 
ATOM   8067 N  N   . LEU D 2 169 ? -48.814 -23.684 36.005  1    33.01  ? 339 LEU D N   1 
ATOM   8068 C  CA  . LEU D 2 169 ? -48.32  -25.048 35.933  1    32.2   ? 339 LEU D CA  1 
ATOM   8069 C  C   . LEU D 2 169 ? -47.377 -25.164 34.747  1    31.68  ? 339 LEU D C   1 
ATOM   8070 O  O   . LEU D 2 169 ? -46.324 -25.785 34.866  1    34.85  ? 339 LEU D O   1 
ATOM   8071 C  CB  . LEU D 2 169 ? -49.448 -26.073 35.856  1    35.11  ? 339 LEU D CB  1 
ATOM   8072 C  CG  . LEU D 2 169 ? -50.214 -26.362 37.153  1    34.05  ? 339 LEU D CG  1 
ATOM   8073 C  CD1 . LEU D 2 169 ? -51.172 -27.531 36.936  1    35.66  ? 339 LEU D CD1 1 
ATOM   8074 C  CD2 . LEU D 2 169 ? -49.284 -26.689 38.307  1    34.15  ? 339 LEU D CD2 1 
ATOM   8075 N  N   . SER D 2 170 ? -47.748 -24.527 33.627  1    29.84  ? 340 SER D N   1 
ATOM   8076 C  CA  . SER D 2 170 ? -46.9   -24.547 32.444  1    30.02  ? 340 SER D CA  1 
ATOM   8077 C  C   . SER D 2 170 ? -45.522 -23.955 32.757  1    36.54  ? 340 SER D C   1 
ATOM   8078 O  O   . SER D 2 170 ? -44.522 -24.39  32.188  1    39.8   ? 340 SER D O   1 
ATOM   8079 C  CB  . SER D 2 170 ? -47.56  -23.882 31.256  1    26.9   ? 340 SER D CB  1 
ATOM   8080 O  OG  . SER D 2 170 ? -47.531 -22.468 31.318  1    28.65  ? 340 SER D OG  1 
ATOM   8081 N  N   . LEU D 2 171 ? -45.457 -22.979 33.679  1    38.78  ? 341 LEU D N   1 
ATOM   8082 C  CA  . LEU D 2 171 ? -44.201 -22.301 33.987  1    35.45  ? 341 LEU D CA  1 
ATOM   8083 C  C   . LEU D 2 171 ? -43.13  -23.323 34.381  1    36.24  ? 341 LEU D C   1 
ATOM   8084 O  O   . LEU D 2 171 ? -41.955 -23.131 34.081  1    34.7   ? 341 LEU D O   1 
ATOM   8085 C  CB  . LEU D 2 171 ? -44.393 -21.225 35.061  1    32.21  ? 341 LEU D CB  1 
ATOM   8086 C  CG  . LEU D 2 171 ? -45.221 -19.998 34.657  1    29.21  ? 341 LEU D CG  1 
ATOM   8087 C  CD1 . LEU D 2 171 ? -45.177 -18.929 35.735  1    27.75  ? 341 LEU D CD1 1 
ATOM   8088 C  CD2 . LEU D 2 171 ? -44.764 -19.414 33.333  1    29.38  ? 341 LEU D CD2 1 
ATOM   8089 N  N   . ILE D 2 172 ? -43.545 -24.436 35.016  1    35.16  ? 342 ILE D N   1 
ATOM   8090 C  CA  . ILE D 2 172 ? -42.619 -25.373 35.634  1    31.84  ? 342 ILE D CA  1 
ATOM   8091 C  C   . ILE D 2 172 ? -41.85  -26.22  34.608  1    32.03  ? 342 ILE D C   1 
ATOM   8092 O  O   . ILE D 2 172 ? -40.735 -26.665 34.882  1    30.14  ? 342 ILE D O   1 
ATOM   8093 C  CB  . ILE D 2 172 ? -43.391 -26.264 36.608  1    30.47  ? 342 ILE D CB  1 
ATOM   8094 C  CG1 . ILE D 2 172 ? -44.095 -25.426 37.697  1    25.44  ? 342 ILE D CG1 1 
ATOM   8095 C  CG2 . ILE D 2 172 ? -42.451 -27.339 37.172  1    31.02  ? 342 ILE D CG2 1 
ATOM   8096 C  CD1 . ILE D 2 172 ? -43.192 -24.979 38.828  1    24.47  ? 342 ILE D CD1 1 
ATOM   8097 N  N   . ASP D 2 173 ? -42.462 -26.445 33.44   1    29.64  ? 343 ASP D N   1 
ATOM   8098 C  CA  . ASP D 2 173 ? -42.059 -27.489 32.52   1    28.54  ? 343 ASP D CA  1 
ATOM   8099 C  C   . ASP D 2 173 ? -41.652 -26.884 31.184  1    31.28  ? 343 ASP D C   1 
ATOM   8100 O  O   . ASP D 2 173 ? -42.477 -26.766 30.275  1    33.65  ? 343 ASP D O   1 
ATOM   8101 C  CB  . ASP D 2 173 ? -43.188 -28.491 32.351  1    28.05  ? 343 ASP D CB  1 
ATOM   8102 C  CG  . ASP D 2 173 ? -43.467 -29.291 33.609  1    34.09  ? 343 ASP D CG  1 
ATOM   8103 O  OD1 . ASP D 2 173 ? -42.472 -29.679 34.257  1    37.92  ? 343 ASP D OD1 1 
ATOM   8104 O  OD2 . ASP D 2 173 ? -44.657 -29.515 33.934  1    34.08  ? 343 ASP D OD2 1 
ATOM   8105 N  N   . ALA D 2 174 ? -40.362 -26.565 31.067  1    32.38  ? 344 ALA D N   1 
ATOM   8106 C  CA  . ALA D 2 174 ? -39.777 -25.979 29.865  1    36.33  ? 344 ALA D CA  1 
ATOM   8107 C  C   . ALA D 2 174 ? -40.057 -26.846 28.642  1    37.74  ? 344 ALA D C   1 
ATOM   8108 O  O   . ALA D 2 174 ? -40.218 -26.33  27.536  1    37.88  ? 344 ALA D O   1 
ATOM   8109 C  CB  . ALA D 2 174 ? -38.285 -25.761 30.053  1    38.03  ? 344 ALA D CB  1 
ATOM   8110 N  N   . ASP D 2 175 ? -40.063 -28.165 28.856  1    36.22  ? 345 ASP D N   1 
ATOM   8111 C  CA  . ASP D 2 175 ? -40.565 -29.108 27.872  1    35.12  ? 345 ASP D CA  1 
ATOM   8112 C  C   . ASP D 2 175 ? -41.924 -29.587 28.373  1    34.01  ? 345 ASP D C   1 
ATOM   8113 O  O   . ASP D 2 175 ? -41.992 -30.185 29.441  1    33.95  ? 345 ASP D O   1 
ATOM   8114 C  CB  . ASP D 2 175 ? -39.585 -30.25  27.639  1    33.5   ? 345 ASP D CB  1 
ATOM   8115 C  CG  . ASP D 2 175 ? -40.125 -31.376 26.779  1    39.26  ? 345 ASP D CG  1 
ATOM   8116 O  OD1 . ASP D 2 175 ? -41.313 -31.324 26.397  1    42.46  ? 345 ASP D OD1 1 
ATOM   8117 O  OD2 . ASP D 2 175 ? -39.357 -32.311 26.51   1    42.46  ? 345 ASP D OD2 1 
ATOM   8118 N  N   . PRO D 2 176 ? -43.042 -29.401 27.628  1    33.3   ? 346 PRO D N   1 
ATOM   8119 C  CA  . PRO D 2 176 ? -43.02  -28.829 26.276  1    32.85  ? 346 PRO D CA  1 
ATOM   8120 C  C   . PRO D 2 176 ? -43.148 -27.313 26.119  1    35.2   ? 346 PRO D C   1 
ATOM   8121 O  O   . PRO D 2 176 ? -43.036 -26.817 25.006  1    38.89  ? 346 PRO D O   1 
ATOM   8122 C  CB  . PRO D 2 176 ? -44.252 -29.539 25.674  1    29.16  ? 346 PRO D CB  1 
ATOM   8123 C  CG  . PRO D 2 176 ? -45.247 -29.583 26.815  1    27.46  ? 346 PRO D CG  1 
ATOM   8124 C  CD  . PRO D 2 176 ? -44.398 -29.8   28.052  1    27.95  ? 346 PRO D CD  1 
ATOM   8125 N  N   . TYR D 2 177 ? -43.353 -26.581 27.217  1    34.02  ? 347 TYR D N   1 
ATOM   8126 C  CA  . TYR D 2 177 ? -44.049 -25.302 27.155  1    33.41  ? 347 TYR D CA  1 
ATOM   8127 C  C   . TYR D 2 177 ? -43.256 -24.182 26.479  1    34.5   ? 347 TYR D C   1 
ATOM   8128 O  O   . TYR D 2 177 ? -43.866 -23.235 25.996  1    37.91  ? 347 TYR D O   1 
ATOM   8129 C  CB  . TYR D 2 177 ? -44.709 -24.938 28.489  1    30.83  ? 347 TYR D CB  1 
ATOM   8130 C  CG  . TYR D 2 177 ? -45.863 -25.875 28.798  1    36.07  ? 347 TYR D CG  1 
ATOM   8131 C  CD1 . TYR D 2 177 ? -47.045 -25.826 28.051  1    35.32  ? 347 TYR D CD1 1 
ATOM   8132 C  CD2 . TYR D 2 177 ? -45.75  -26.867 29.772  1    40.13  ? 347 TYR D CD2 1 
ATOM   8133 C  CE1 . TYR D 2 177 ? -48.086 -26.714 28.289  1    35.71  ? 347 TYR D CE1 1 
ATOM   8134 C  CE2 . TYR D 2 177 ? -46.79  -27.759 30.015  1    37.9   ? 347 TYR D CE2 1 
ATOM   8135 C  CZ  . TYR D 2 177 ? -47.963 -27.685 29.276  1    35.42  ? 347 TYR D CZ  1 
ATOM   8136 O  OH  . TYR D 2 177 ? -48.997 -28.546 29.529  1    30.1   ? 347 TYR D OH  1 
ATOM   8137 N  N   . LEU D 2 178 ? -41.929 -24.27  26.412  1    35.8   ? 348 LEU D N   1 
ATOM   8138 C  CA  . LEU D 2 178 ? -41.151 -23.202 25.785  1    40.49  ? 348 LEU D CA  1 
ATOM   8139 C  C   . LEU D 2 178 ? -41.423 -23.075 24.283  1    42.99  ? 348 LEU D C   1 
ATOM   8140 O  O   . LEU D 2 178 ? -41.045 -22.09  23.651  1    49.28  ? 348 LEU D O   1 
ATOM   8141 C  CB  . LEU D 2 178 ? -39.654 -23.386 26.026  1    39.93  ? 348 LEU D CB  1 
ATOM   8142 C  CG  . LEU D 2 178 ? -39.121 -22.976 27.401  1    39.35  ? 348 LEU D CG  1 
ATOM   8143 C  CD1 . LEU D 2 178 ? -37.618 -23.21  27.444  1    40.27  ? 348 LEU D CD1 1 
ATOM   8144 C  CD2 . LEU D 2 178 ? -39.428 -21.543 27.703  1    35.97  ? 348 LEU D CD2 1 
ATOM   8145 N  N   . LYS D 2 179 ? -42.054 -24.075 23.682  1    44.36  ? 349 LYS D N   1 
ATOM   8146 C  CA  . LYS D 2 179 ? -42.32  -23.955 22.259  1    46.56  ? 349 LYS D CA  1 
ATOM   8147 C  C   . LYS D 2 179 ? -43.696 -23.339 22.005  1    42.54  ? 349 LYS D C   1 
ATOM   8148 O  O   . LYS D 2 179 ? -44.117 -23.297 20.861  1    52.14  ? 349 LYS D O   1 
ATOM   8149 C  CB  . LYS D 2 179 ? -42.087 -25.276 21.516  1    43.72  ? 349 LYS D CB  1 
ATOM   8150 C  CG  . LYS D 2 179 ? -43.07  -26.394 21.806  1    44.14  ? 349 LYS D CG  1 
ATOM   8151 C  CD  . LYS D 2 179 ? -42.567 -27.799 21.456  1    43.05  ? 349 LYS D CD  1 
ATOM   8152 C  CE  . LYS D 2 179 ? -43.597 -28.822 21.849  1    48.13  ? 349 LYS D CE  1 
ATOM   8153 N  NZ  . LYS D 2 179 ? -43.15  -30.208 21.698  1    55.31  ? 349 LYS D NZ  1 
ATOM   8154 N  N   . TYR D 2 180 ? -44.399 -22.878 23.047  1    37.17  ? 350 TYR D N   1 
ATOM   8155 C  CA  . TYR D 2 180 ? -45.607 -22.093 22.845  1    36.02  ? 350 TYR D CA  1 
ATOM   8156 C  C   . TYR D 2 180 ? -45.349 -20.655 23.302  1    37.52  ? 350 TYR D C   1 
ATOM   8157 O  O   . TYR D 2 180 ? -44.575 -20.43  24.223  1    37.07  ? 350 TYR D O   1 
ATOM   8158 C  CB  . TYR D 2 180 ? -46.814 -22.723 23.545  1    39.14  ? 350 TYR D CB  1 
ATOM   8159 C  CG  . TYR D 2 180 ? -47.111 -24.168 23.153  1    38.1   ? 350 TYR D CG  1 
ATOM   8160 C  CD1 . TYR D 2 180 ? -47.485 -24.513 21.857  1    35.32  ? 350 TYR D CD1 1 
ATOM   8161 C  CD2 . TYR D 2 180 ? -47.012 -25.191 24.089  1    36.3   ? 350 TYR D CD2 1 
ATOM   8162 C  CE1 . TYR D 2 180 ? -47.727 -25.831 21.508  1    34.86  ? 350 TYR D CE1 1 
ATOM   8163 C  CE2 . TYR D 2 180 ? -47.268 -26.511 23.753  1    34.58  ? 350 TYR D CE2 1 
ATOM   8164 C  CZ  . TYR D 2 180 ? -47.627 -26.838 22.459  1    36.62  ? 350 TYR D CZ  1 
ATOM   8165 O  OH  . TYR D 2 180 ? -47.883 -28.16  22.156  1    40.27  ? 350 TYR D OH  1 
ATOM   8166 N  N   . LEU D 2 181 ? -45.955 -19.684 22.608  1    33.91  ? 351 LEU D N   1 
ATOM   8167 C  CA  . LEU D 2 181 ? -45.952 -18.291 23.008  1    33.54  ? 351 LEU D CA  1 
ATOM   8168 C  C   . LEU D 2 181 ? -46.943 -18.078 24.15   1    36.85  ? 351 LEU D C   1 
ATOM   8169 O  O   . LEU D 2 181 ? -47.979 -18.732 24.22   1    37.15  ? 351 LEU D O   1 
ATOM   8170 C  CB  . LEU D 2 181 ? -46.328 -17.386 21.84   1    33.76  ? 351 LEU D CB  1 
ATOM   8171 C  CG  . LEU D 2 181 ? -45.325 -17.261 20.694  1    33.85  ? 351 LEU D CG  1 
ATOM   8172 C  CD1 . LEU D 2 181 ? -45.935 -16.434 19.574  1    32.63  ? 351 LEU D CD1 1 
ATOM   8173 C  CD2 . LEU D 2 181 ? -44.047 -16.637 21.19   1    34.15  ? 351 LEU D CD2 1 
ATOM   8174 N  N   . PRO D 2 182 ? -46.667 -17.123 25.068  1    38.27  ? 352 PRO D N   1 
ATOM   8175 C  CA  . PRO D 2 182 ? -47.583 -16.813 26.166  1    38.97  ? 352 PRO D CA  1 
ATOM   8176 C  C   . PRO D 2 182 ? -49.041 -16.658 25.778  1    36.83  ? 352 PRO D C   1 
ATOM   8177 O  O   . PRO D 2 182 ? -49.919 -17.149 26.48   1    42.25  ? 352 PRO D O   1 
ATOM   8178 C  CB  . PRO D 2 182 ? -47     -15.518 26.737  1    39.69  ? 352 PRO D CB  1 
ATOM   8179 C  CG  . PRO D 2 182 ? -45.518 -15.699 26.524  1    39.92  ? 352 PRO D CG  1 
ATOM   8180 C  CD  . PRO D 2 182 ? -45.409 -16.367 25.149  1    34.39  ? 352 PRO D CD  1 
ATOM   8181 N  N   . SER D 2 183 ? -49.28  -15.967 24.661  1    38.17  ? 353 SER D N   1 
ATOM   8182 C  CA  . SER D 2 183 ? -50.634 -15.69  24.205  1    35.35  ? 353 SER D CA  1 
ATOM   8183 C  C   . SER D 2 183 ? -51.386 -16.99  23.953  1    37.19  ? 353 SER D C   1 
ATOM   8184 O  O   . SER D 2 183 ? -52.583 -17.055 24.224  1    42.43  ? 353 SER D O   1 
ATOM   8185 C  CB  . SER D 2 183 ? -50.636 -14.822 22.992  1    34.74  ? 353 SER D CB  1 
ATOM   8186 O  OG  . SER D 2 183 ? -49.952 -15.478 21.94   1    40.86  ? 353 SER D OG  1 
ATOM   8187 N  N   . VAL D 2 184 ? -50.677 -18.005 23.426  1    35.78  ? 354 VAL D N   1 
ATOM   8188 C  CA  . VAL D 2 184 ? -51.271 -19.3   23.125  1    32.66  ? 354 VAL D CA  1 
ATOM   8189 C  C   . VAL D 2 184 ? -51.536 -20.04  24.434  1    32.9   ? 354 VAL D C   1 
ATOM   8190 O  O   . VAL D 2 184 ? -52.64  -20.546 24.648  1    30.32  ? 354 VAL D O   1 
ATOM   8191 C  CB  . VAL D 2 184 ? -50.415 -20.148 22.167  1    31.22  ? 354 VAL D CB  1 
ATOM   8192 C  CG1 . VAL D 2 184 ? -50.968 -21.561 22.001  1    26.23  ? 354 VAL D CG1 1 
ATOM   8193 C  CG2 . VAL D 2 184 ? -50.23  -19.469 20.821  1    28.11  ? 354 VAL D CG2 1 
ATOM   8194 N  N   . ILE D 2 185 ? -50.509 -20.105 25.292  1    31     ? 355 ILE D N   1 
ATOM   8195 C  CA  . ILE D 2 185 ? -50.659 -20.785 26.567  1    32.74  ? 355 ILE D CA  1 
ATOM   8196 C  C   . ILE D 2 185 ? -51.794 -20.142 27.358  1    37.44  ? 355 ILE D C   1 
ATOM   8197 O  O   . ILE D 2 185 ? -52.607 -20.854 27.937  1    46.27  ? 355 ILE D O   1 
ATOM   8198 C  CB  . ILE D 2 185 ? -49.355 -20.825 27.371  1    29.85  ? 355 ILE D CB  1 
ATOM   8199 C  CG1 . ILE D 2 185 ? -48.288 -21.6   26.623  1    29.13  ? 355 ILE D CG1 1 
ATOM   8200 C  CG2 . ILE D 2 185 ? -49.613 -21.434 28.744  1    31.15  ? 355 ILE D CG2 1 
ATOM   8201 C  CD1 . ILE D 2 185 ? -46.982 -21.706 27.388  1    27.55  ? 355 ILE D CD1 1 
ATOM   8202 N  N   . ALA D 2 186 ? -51.87  -18.808 27.363  1    32.95  ? 356 ALA D N   1 
ATOM   8203 C  CA  . ALA D 2 186 ? -52.971 -18.139 28.045  1    33.69  ? 356 ALA D CA  1 
ATOM   8204 C  C   . ALA D 2 186 ? -54.331 -18.584 27.497  1    34.53  ? 356 ALA D C   1 
ATOM   8205 O  O   . ALA D 2 186 ? -55.27  -18.774 28.271  1    30.8   ? 356 ALA D O   1 
ATOM   8206 C  CB  . ALA D 2 186 ? -52.826 -16.65  27.947  1    32.72  ? 356 ALA D CB  1 
ATOM   8207 N  N   . ALA D 2 187 ? -54.431 -18.723 26.164  1    33.97  ? 357 ALA D N   1 
ATOM   8208 C  CA  . ALA D 2 187 ? -55.663 -19.15  25.509  1    33.36  ? 357 ALA D CA  1 
ATOM   8209 C  C   . ALA D 2 187 ? -56.035 -20.573 25.932  1    35.38  ? 357 ALA D C   1 
ATOM   8210 O  O   . ALA D 2 187 ? -57.176 -20.823 26.296  1    37.01  ? 357 ALA D O   1 
ATOM   8211 C  CB  . ALA D 2 187 ? -55.53  -19.023 24.011  1    28.41  ? 357 ALA D CB  1 
ATOM   8212 N  N   . ALA D 2 188 ? -55.075 -21.504 25.903  1    36.83  ? 358 ALA D N   1 
ATOM   8213 C  CA  . ALA D 2 188 ? -55.39  -22.885 26.23   1    40.06  ? 358 ALA D CA  1 
ATOM   8214 C  C   . ALA D 2 188 ? -55.797 -22.984 27.695  1    38.23  ? 358 ALA D C   1 
ATOM   8215 O  O   . ALA D 2 188 ? -56.713 -23.729 28.037  1    41.04  ? 358 ALA D O   1 
ATOM   8216 C  CB  . ALA D 2 188 ? -54.226 -23.795 25.904  1    41.21  ? 358 ALA D CB  1 
ATOM   8217 N  N   . ALA D 2 189 ? -55.118 -22.222 28.55   1    38.01  ? 359 ALA D N   1 
ATOM   8218 C  CA  . ALA D 2 189 ? -55.428 -22.227 29.972  1    43.17  ? 359 ALA D CA  1 
ATOM   8219 C  C   . ALA D 2 189 ? -56.833 -21.661 30.215  1    46.16  ? 359 ALA D C   1 
ATOM   8220 O  O   . ALA D 2 189 ? -57.543 -22.118 31.112  1    48.58  ? 359 ALA D O   1 
ATOM   8221 C  CB  . ALA D 2 189 ? -54.362 -21.477 30.735  1    35.92  ? 359 ALA D CB  1 
ATOM   8222 N  N   . PHE D 2 190 ? -57.236 -20.687 29.396  1    42.94  ? 360 PHE D N   1 
ATOM   8223 C  CA  . PHE D 2 190 ? -58.559 -20.035 29.586  1    40.4   ? 360 PHE D CA  1 
ATOM   8224 C  C   . PHE D 2 190 ? -59.654 -20.983 29.139  1    42.68  ? 360 PHE D C   1 
ATOM   8225 O  O   . PHE D 2 190 ? -60.578 -21.254 29.925  1    45.28  ? 360 PHE D O   1 
ATOM   8226 C  CB  . PHE D 2 190 ? -58.674 -18.731 28.799  1    35.94  ? 360 PHE D CB  1 
ATOM   8227 C  CG  . PHE D 2 190 ? -59.951 -17.949 29.067  1    34.69  ? 360 PHE D CG  1 
ATOM   8228 C  CD1 . PHE D 2 190 ? -60.46  -17.835 30.355  1    33.69  ? 360 PHE D CD1 1 
ATOM   8229 C  CD2 . PHE D 2 190 ? -60.639 -17.33  28.032  1    37.36  ? 360 PHE D CD2 1 
ATOM   8230 C  CE1 . PHE D 2 190 ? -61.622 -17.122 30.594  1    33.26  ? 360 PHE D CE1 1 
ATOM   8231 C  CE2 . PHE D 2 190 ? -61.799 -16.62  28.279  1    31.57  ? 360 PHE D CE2 1 
ATOM   8232 C  CZ  . PHE D 2 190 ? -62.287 -16.516 29.557  1    31.29  ? 360 PHE D CZ  1 
ATOM   8233 N  N   . HIS D 2 191 ? -59.561 -21.468 27.903  1    40.3   ? 361 HIS D N   1 
ATOM   8234 C  CA  . HIS D 2 191 ? -60.552 -22.455 27.413  1    38.36  ? 361 HIS D CA  1 
ATOM   8235 C  C   . HIS D 2 191 ? -60.7   -23.581 28.433  1    38.59  ? 361 HIS D C   1 
ATOM   8236 O  O   . HIS D 2 191 ? -61.817 -23.823 28.914  1    43.71  ? 361 HIS D O   1 
ATOM   8237 C  CB  . HIS D 2 191 ? -60.106 -23.075 26.091  1    36.32  ? 361 HIS D CB  1 
ATOM   8238 C  CG  . HIS D 2 191 ? -60.894 -24.297 25.765  1    36.79  ? 361 HIS D CG  1 
ATOM   8239 N  ND1 . HIS D 2 191 ? -62.189 -24.235 25.304  1    35.19  ? 361 HIS D ND1 1 
ATOM   8240 C  CD2 . HIS D 2 191 ? -60.598 -25.596 25.866  1    34.23  ? 361 HIS D CD2 1 
ATOM   8241 C  CE1 . HIS D 2 191 ? -62.642 -25.464 25.121  1    34.44  ? 361 HIS D CE1 1 
ATOM   8242 N  NE2 . HIS D 2 191 ? -61.693 -26.305 25.458  1    33.73  ? 361 HIS D NE2 1 
ATOM   8243 N  N   . LEU D 2 192 ? -59.6   -24.258 28.748  1    35.25  ? 362 LEU D N   1 
ATOM   8244 C  CA  . LEU D 2 192 ? -59.668 -25.418 29.665  1    37.52  ? 362 LEU D CA  1 
ATOM   8245 C  C   . LEU D 2 192 ? -60.468 -25.049 30.916  1    37.02  ? 362 LEU D C   1 
ATOM   8246 O  O   . LEU D 2 192 ? -61.314 -25.86  31.325  1    38.89  ? 362 LEU D O   1 
ATOM   8247 C  CB  . LEU D 2 192 ? -58.242 -25.843 30.001  1    42.02  ? 362 LEU D CB  1 
ATOM   8248 C  CG  . LEU D 2 192 ? -58.049 -27.265 30.533  1    44.64  ? 362 LEU D CG  1 
ATOM   8249 C  CD1 . LEU D 2 192 ? -58.951 -28.243 29.812  1    40.2   ? 362 LEU D CD1 1 
ATOM   8250 C  CD2 . LEU D 2 192 ? -56.594 -27.674 30.386  1    41.31  ? 362 LEU D CD2 1 
ATOM   8251 N  N   . ALA D 2 193 ? -60.22  -23.876 31.489  1    38.98  ? 363 ALA D N   1 
ATOM   8252 C  CA  . ALA D 2 193 ? -60.893 -23.49  32.751  1    43.91  ? 363 ALA D CA  1 
ATOM   8253 C  C   . ALA D 2 193 ? -62.378 -23.232 32.512  1    49.46  ? 363 ALA D C   1 
ATOM   8254 O  O   . ALA D 2 193 ? -63.205 -23.67  33.335  1    49.68  ? 363 ALA D O   1 
ATOM   8255 C  CB  . ALA D 2 193 ? -60.226 -22.267 33.316  1    39.14  ? 363 ALA D CB  1 
ATOM   8256 N  N   . LEU D 2 194 ? -62.7   -22.534 31.424  1    51.97  ? 364 LEU D N   1 
ATOM   8257 C  CA  . LEU D 2 194 ? -64.11  -22.216 31.091  1    48.08  ? 364 LEU D CA  1 
ATOM   8258 C  C   . LEU D 2 194 ? -64.883 -23.527 30.931  1    48.2   ? 364 LEU D C   1 
ATOM   8259 O  O   . LEU D 2 194 ? -66.039 -23.596 31.383  1    51.2   ? 364 LEU D O   1 
ATOM   8260 C  CB  . LEU D 2 194 ? -64.111 -21.397 29.805  1    46.84  ? 364 LEU D CB  1 
ATOM   8261 C  CG  . LEU D 2 194 ? -65.331 -20.507 29.562  1    52.22  ? 364 LEU D CG  1 
ATOM   8262 C  CD1 . LEU D 2 194 ? -65.612 -19.671 30.793  1    56.83  ? 364 LEU D CD1 1 
ATOM   8263 C  CD2 . LEU D 2 194 ? -65.062 -19.616 28.364  1    49.53  ? 364 LEU D CD2 1 
ATOM   8264 N  N   . TYR D 2 195 ? -64.254 -24.528 30.323  1    44.13  ? 365 TYR D N   1 
ATOM   8265 C  CA  . TYR D 2 195 ? -64.915 -25.836 30.111  1    41.57  ? 365 TYR D CA  1 
ATOM   8266 C  C   . TYR D 2 195 ? -65.082 -26.533 31.439  1    39.85  ? 365 TYR D C   1 
ATOM   8267 O  O   . TYR D 2 195 ? -66.207 -26.919 31.787  1    39.41  ? 365 TYR D O   1 
ATOM   8268 C  CB  . TYR D 2 195 ? -63.969 -26.579 29.169  1    42.27  ? 365 TYR D CB  1 
ATOM   8269 C  CG  . TYR D 2 195 ? -64.431 -27.94  28.677  1    47.46  ? 365 TYR D CG  1 
ATOM   8270 C  CD1 . TYR D 2 195 ? -65.382 -28.05  27.674  1    50.97  ? 365 TYR D CD1 1 
ATOM   8271 C  CD2 . TYR D 2 195 ? -63.896 -29.11  29.199  1    47.51  ? 365 TYR D CD2 1 
ATOM   8272 C  CE1 . TYR D 2 195 ? -65.798 -29.286 27.213  1    49.42  ? 365 TYR D CE1 1 
ATOM   8273 C  CE2 . TYR D 2 195 ? -64.305 -30.352 28.747  1    49.38  ? 365 TYR D CE2 1 
ATOM   8274 C  CZ  . TYR D 2 195 ? -65.257 -30.44  27.749  1    51.78  ? 365 TYR D CZ  1 
ATOM   8275 O  OH  . TYR D 2 195 ? -65.669 -31.66  27.298  1    58.71  ? 365 TYR D OH  1 
ATOM   8276 N  N   . THR D 2 196 ? -63.997 -26.663 32.19   1    34.49  ? 366 THR D N   1 
ATOM   8277 C  CA  . THR D 2 196 ? -64.043 -27.43  33.447  1    32.48  ? 366 THR D CA  1 
ATOM   8278 C  C   . THR D 2 196 ? -65.084 -26.89  34.401  1    32.08  ? 366 THR D C   1 
ATOM   8279 O  O   . THR D 2 196 ? -65.758 -27.713 35.044  1    30.68  ? 366 THR D O   1 
ATOM   8280 C  CB  . THR D 2 196 ? -62.645 -27.397 34.063  1    32.69  ? 366 THR D CB  1 
ATOM   8281 O  OG1 . THR D 2 196 ? -61.766 -27.796 33.017  1    35.4   ? 366 THR D OG1 1 
ATOM   8282 C  CG2 . THR D 2 196 ? -62.502 -28.325 35.257  1    28.46  ? 366 THR D CG2 1 
ATOM   8283 N  N   . VAL D 2 197 ? -65.264 -25.575 34.482  1    32.25  ? 367 VAL D N   1 
ATOM   8284 C  CA  . VAL D 2 197 ? -66.131 -25.023 35.512  1    35.97  ? 367 VAL D CA  1 
ATOM   8285 C  C   . VAL D 2 197 ? -67.551 -24.843 34.985  1    40.24  ? 367 VAL D C   1 
ATOM   8286 O  O   . VAL D 2 197 ? -68.497 -25.189 35.69   1    43.68  ? 367 VAL D O   1 
ATOM   8287 C  CB  . VAL D 2 197 ? -65.589 -23.727 36.141  1    36.88  ? 367 VAL D CB  1 
ATOM   8288 C  CG1 . VAL D 2 197 ? -66.533 -23.171 37.195  1    34.12  ? 367 VAL D CG1 1 
ATOM   8289 C  CG2 . VAL D 2 197 ? -64.205 -23.936 36.743  1    37.11  ? 367 VAL D CG2 1 
ATOM   8290 N  N   . THR D 2 198 ? -67.698 -24.313 33.761  1    42.39  ? 368 THR D N   1 
ATOM   8291 C  CA  . THR D 2 198 ? -69.014 -23.955 33.234  1    44.76  ? 368 THR D CA  1 
ATOM   8292 C  C   . THR D 2 198 ? -69.503 -24.922 32.155  1    42.1   ? 368 THR D C   1 
ATOM   8293 O  O   . THR D 2 198 ? -70.701 -25.169 32.067  1    43.69  ? 368 THR D O   1 
ATOM   8294 C  CB  . THR D 2 198 ? -69.064 -22.512 32.73   1    47.39  ? 368 THR D CB  1 
ATOM   8295 O  OG1 . THR D 2 198 ? -68.145 -22.384 31.647  1    55.62  ? 368 THR D OG1 1 
ATOM   8296 C  CG2 . THR D 2 198 ? -68.782 -21.502 33.828  1    47.76  ? 368 THR D CG2 1 
ATOM   8297 N  N   . GLY D 2 199 ? -68.59  -25.425 31.316  1    40.89  ? 369 GLY D N   1 
ATOM   8298 C  CA  . GLY D 2 199 ? -68.957 -26.298 30.213  1    39.76  ? 369 GLY D CA  1 
ATOM   8299 C  C   . GLY D 2 199 ? -68.766 -25.636 28.849  1    39.96  ? 369 GLY D C   1 
ATOM   8300 O  O   . GLY D 2 199 ? -69.044 -26.251 27.823  1    36.18  ? 369 GLY D O   1 
ATOM   8301 N  N   . GLN D 2 200 ? -68.227 -24.409 28.845  1    44.1   ? 370 GLN D N   1 
ATOM   8302 C  CA  . GLN D 2 200 ? -68.188 -23.561 27.656  1    47.22  ? 370 GLN D CA  1 
ATOM   8303 C  C   . GLN D 2 200 ? -66.806 -23.562 26.992  1    45.35  ? 370 GLN D C   1 
ATOM   8304 O  O   . GLN D 2 200 ? -65.866 -24.188 27.486  1    47.6   ? 370 GLN D O   1 
ATOM   8305 C  CB  . GLN D 2 200 ? -68.615 -22.155 28.072  1    48.02  ? 370 GLN D CB  1 
ATOM   8306 C  CG  . GLN D 2 200 ? -69.85  -22.142 28.962  1    50     ? 370 GLN D CG  1 
ATOM   8307 C  CD  . GLN D 2 200 ? -69.913 -20.907 29.829  1    53.76  ? 370 GLN D CD  1 
ATOM   8308 O  OE1 . GLN D 2 200 ? -68.942 -20.149 29.942  1    62.05  ? 370 GLN D OE1 1 
ATOM   8309 N  NE2 . GLN D 2 200 ? -71.051 -20.714 30.476  1    60.49  ? 370 GLN D NE2 1 
ATOM   8310 N  N   . SER D 2 201 ? -66.68  -22.857 25.854  1    41.04  ? 371 SER D N   1 
ATOM   8311 C  CA  . SER D 2 201 ? -65.475 -22.96  25.039  1    43.92  ? 371 SER D CA  1 
ATOM   8312 C  C   . SER D 2 201 ? -64.917 -21.588 24.657  1    47.81  ? 371 SER D C   1 
ATOM   8313 O  O   . SER D 2 201 ? -65.594 -20.577 24.818  1    50.59  ? 371 SER D O   1 
ATOM   8314 C  CB  . SER D 2 201 ? -65.697 -23.831 23.834  1    38.65  ? 371 SER D CB  1 
ATOM   8315 O  OG  . SER D 2 201 ? -65.722 -25.197 24.215  1    38.71  ? 371 SER D OG  1 
ATOM   8316 N  N   . TRP D 2 202 ? -63.664 -21.574 24.174  1    46.55  ? 372 TRP D N   1 
ATOM   8317 C  CA  . TRP D 2 202 ? -63.038 -20.396 23.587  1    45.62  ? 372 TRP D CA  1 
ATOM   8318 C  C   . TRP D 2 202 ? -64.098 -19.539 22.896  1    42.77  ? 372 TRP D C   1 
ATOM   8319 O  O   . TRP D 2 202 ? -64.6   -19.894 21.83   1    37.82  ? 372 TRP D O   1 
ATOM   8320 C  CB  . TRP D 2 202 ? -61.917 -20.8   22.611  1    42.4   ? 372 TRP D CB  1 
ATOM   8321 C  CG  . TRP D 2 202 ? -60.953 -19.715 22.212  1    39.57  ? 372 TRP D CG  1 
ATOM   8322 C  CD1 . TRP D 2 202 ? -60.635 -19.357 20.936  1    39.22  ? 372 TRP D CD1 1 
ATOM   8323 C  CD2 . TRP D 2 202 ? -60.153 -18.876 23.081  1    41.22  ? 372 TRP D CD2 1 
ATOM   8324 N  NE1 . TRP D 2 202 ? -59.706 -18.344 20.947  1    44.2   ? 372 TRP D NE1 1 
ATOM   8325 C  CE2 . TRP D 2 202 ? -59.39  -18.03  22.243  1    40.22  ? 372 TRP D CE2 1 
ATOM   8326 C  CE3 . TRP D 2 202 ? -60.018 -18.735 24.471  1    41.68  ? 372 TRP D CE3 1 
ATOM   8327 C  CZ2 . TRP D 2 202 ? -58.518 -17.069 22.749  1    41.54  ? 372 TRP D CZ2 1 
ATOM   8328 C  CZ3 . TRP D 2 202 ? -59.138 -17.791 24.968  1    43.94  ? 372 TRP D CZ3 1 
ATOM   8329 C  CH2 . TRP D 2 202 ? -58.406 -16.955 24.123  1    44.37  ? 372 TRP D CH2 1 
ATOM   8330 N  N   . PRO D 2 203 ? -64.477 -18.393 23.508  1    44.09  ? 373 PRO D N   1 
ATOM   8331 C  CA  . PRO D 2 203 ? -65.48  -17.494 22.932  1    41.7   ? 373 PRO D CA  1 
ATOM   8332 C  C   . PRO D 2 203 ? -65.077 -16.946 21.563  1    40.16  ? 373 PRO D C   1 
ATOM   8333 O  O   . PRO D 2 203 ? -63.897 -16.836 21.242  1    43.29  ? 373 PRO D O   1 
ATOM   8334 C  CB  . PRO D 2 203 ? -65.627 -16.387 23.992  1    42.78  ? 373 PRO D CB  1 
ATOM   8335 C  CG  . PRO D 2 203 ? -64.324 -16.443 24.785  1    47.42  ? 373 PRO D CG  1 
ATOM   8336 C  CD  . PRO D 2 203 ? -63.945 -17.915 24.799  1    48.09  ? 373 PRO D CD  1 
ATOM   8337 N  N   . GLU D 2 204 ? -66.089 -16.605 20.768  1    38.9   ? 374 GLU D N   1 
ATOM   8338 C  CA  . GLU D 2 204 ? -65.902 -16.15  19.403  1    38.78  ? 374 GLU D CA  1 
ATOM   8339 C  C   . GLU D 2 204 ? -65.299 -14.747 19.413  1    37.64  ? 374 GLU D C   1 
ATOM   8340 O  O   . GLU D 2 204 ? -64.46  -14.437 18.572  1    37.74  ? 374 GLU D O   1 
ATOM   8341 C  CB  . GLU D 2 204 ? -67.255 -16.245 18.682  1    33.76  ? 374 GLU D CB  1 
ATOM   8342 C  CG  . GLU D 2 204 ? -67.264 -15.598 17.298  1    34.06  ? 374 GLU D CG  1 
ATOM   8343 C  CD  . GLU D 2 204 ? -66.401 -16.275 16.244  1    37.99  ? 374 GLU D CD  1 
ATOM   8344 O  OE1 . GLU D 2 204 ? -66.02  -17.462 16.395  1    36.64  ? 374 GLU D OE1 1 
ATOM   8345 O  OE2 . GLU D 2 204 ? -66.108 -15.58  15.247  1    42.28  ? 374 GLU D OE2 1 
ATOM   8346 N  N   . SER D 2 205 ? -65.755 -13.91  20.354  1    37.45  ? 375 SER D N   1 
ATOM   8347 C  CA  . SER D 2 205 ? -65.204 -12.581 20.558  1    40.3   ? 375 SER D CA  1 
ATOM   8348 C  C   . SER D 2 205 ? -63.67  -12.621 20.67   1    41.59  ? 375 SER D C   1 
ATOM   8349 O  O   . SER D 2 205 ? -62.982 -11.731 20.168  1    38.29  ? 375 SER D O   1 
ATOM   8350 C  CB  . SER D 2 205 ? -65.846 -11.921 21.757  1    40.8   ? 375 SER D CB  1 
ATOM   8351 O  OG  . SER D 2 205 ? -65.729 -12.724 22.925  1    38.48  ? 375 SER D OG  1 
ATOM   8352 N  N   . LEU D 2 206 ? -63.143 -13.669 21.317  1    40.34  ? 376 LEU D N   1 
ATOM   8353 C  CA  . LEU D 2 206 ? -61.709 -13.87  21.477  1    39.72  ? 376 LEU D CA  1 
ATOM   8354 C  C   . LEU D 2 206 ? -61.114 -14.549 20.247  1    38.61  ? 376 LEU D C   1 
ATOM   8355 O  O   . LEU D 2 206 ? -59.898 -14.491 20.061  1    43.83  ? 376 LEU D O   1 
ATOM   8356 C  CB  . LEU D 2 206 ? -61.399 -14.695 22.723  1    36.79  ? 376 LEU D CB  1 
ATOM   8357 C  CG  . LEU D 2 206 ? -61.608 -13.997 24.066  1    34.61  ? 376 LEU D CG  1 
ATOM   8358 C  CD1 . LEU D 2 206 ? -61.395 -14.971 25.195  1    35.83  ? 376 LEU D CD1 1 
ATOM   8359 C  CD2 . LEU D 2 206 ? -60.677 -12.81  24.194  1    37.25  ? 376 LEU D CD2 1 
ATOM   8360 N  N   . VAL D 2 207 ? -61.958 -15.215 19.456  1    30.66  ? 377 VAL D N   1 
ATOM   8361 C  CA  . VAL D 2 207 ? -61.498 -15.709 18.175  1    32.48  ? 377 VAL D CA  1 
ATOM   8362 C  C   . VAL D 2 207 ? -61.193 -14.518 17.27   1    35.88  ? 377 VAL D C   1 
ATOM   8363 O  O   . VAL D 2 207 ? -60.224 -14.548 16.51   1    38.75  ? 377 VAL D O   1 
ATOM   8364 C  CB  . VAL D 2 207 ? -62.509 -16.676 17.518  1    34.89  ? 377 VAL D CB  1 
ATOM   8365 C  CG1 . VAL D 2 207 ? -62.05  -17.104 16.125  1    29.85  ? 377 VAL D CG1 1 
ATOM   8366 C  CG2 . VAL D 2 207 ? -62.742 -17.899 18.398  1    35.3   ? 377 VAL D CG2 1 
ATOM   8367 N  N   . GLN D 2 208 ? -62.039 -13.483 17.339  1    38.07  ? 378 GLN D N   1 
ATOM   8368 C  CA  . GLN D 2 208 ? -61.901 -12.327 16.466  1    40.01  ? 378 GLN D CA  1 
ATOM   8369 C  C   . GLN D 2 208 ? -60.717 -11.462 16.891  1    38.44  ? 378 GLN D C   1 
ATOM   8370 O  O   . GLN D 2 208 ? -60.067 -10.862 16.037  1    39.3   ? 378 GLN D O   1 
ATOM   8371 C  CB  . GLN D 2 208 ? -63.197 -11.522 16.408  1    42.1   ? 378 GLN D CB  1 
ATOM   8372 C  CG  . GLN D 2 208 ? -64.234 -12.167 15.502  1    46.66  ? 378 GLN D CG  1 
ATOM   8373 C  CD  . GLN D 2 208 ? -63.733 -12.27  14.077  1    51.84  ? 378 GLN D CD  1 
ATOM   8374 O  OE1 . GLN D 2 208 ? -63.311 -13.339 13.625  1    51.71  ? 378 GLN D OE1 1 
ATOM   8375 N  NE2 . GLN D 2 208 ? -63.724 -11.149 13.369  1    55.18  ? 378 GLN D NE2 1 
ATOM   8376 N  N   . LYS D 2 209 ? -60.444 -11.411 18.202  1    35.34  ? 379 LYS D N   1 
ATOM   8377 C  CA  . LYS D 2 209 ? -59.403 -10.561 18.756  1    36.72  ? 379 LYS D CA  1 
ATOM   8378 C  C   . LYS D 2 209 ? -58.016 -11.167 18.535  1    37.4   ? 379 LYS D C   1 
ATOM   8379 O  O   . LYS D 2 209 ? -57.076 -10.438 18.208  1    35.72  ? 379 LYS D O   1 
ATOM   8380 C  CB  . LYS D 2 209 ? -59.619 -10.351 20.26   1    41.46  ? 379 LYS D CB  1 
ATOM   8381 C  CG  . LYS D 2 209 ? -58.729 -9.294  20.927  1    42.79  ? 379 LYS D CG  1 
ATOM   8382 C  CD  . LYS D 2 209 ? -58.749 -9.43   22.446  1    45.99  ? 379 LYS D CD  1 
ATOM   8383 C  CE  . LYS D 2 209 ? -57.983 -8.426  23.226  1    41.97  ? 379 LYS D CE  1 
ATOM   8384 N  NZ  . LYS D 2 209 ? -58.502 -7.079  23.034  1    40.8   ? 379 LYS D NZ  1 
ATOM   8385 N  N   . THR D 2 210 ? -57.889 -12.492 18.724  1    34.94  ? 380 THR D N   1 
ATOM   8386 C  CA  . THR D 2 210 ? -56.588 -13.152 18.755  1    34.34  ? 380 THR D CA  1 
ATOM   8387 C  C   . THR D 2 210 ? -56.23  -13.792 17.412  1    35.15  ? 380 THR D C   1 
ATOM   8388 O  O   . THR D 2 210 ? -55.057 -14.028 17.131  1    33.96  ? 380 THR D O   1 
ATOM   8389 C  CB  . THR D 2 210 ? -56.555 -14.198 19.87   1    36.25  ? 380 THR D CB  1 
ATOM   8390 O  OG1 . THR D 2 210 ? -57.461 -15.251 19.536  1    32.94  ? 380 THR D OG1 1 
ATOM   8391 C  CG2 . THR D 2 210 ? -56.864 -13.589 21.228  1    35.64  ? 380 THR D CG2 1 
ATOM   8392 N  N   . GLY D 2 211 ? -57.243 -14.107 16.599  1    38.1   ? 381 GLY D N   1 
ATOM   8393 C  CA  . GLY D 2 211 ? -57.033 -14.922 15.417  1    34.6   ? 381 GLY D CA  1 
ATOM   8394 C  C   . GLY D 2 211 ? -56.793 -16.386 15.777  1    36.15  ? 381 GLY D C   1 
ATOM   8395 O  O   . GLY D 2 211 ? -56.433 -17.152 14.894  1    42.54  ? 381 GLY D O   1 
ATOM   8396 N  N   . TYR D 2 212 ? -57.023 -16.771 17.046  1    36.27  ? 382 TYR D N   1 
ATOM   8397 C  CA  . TYR D 2 212 ? -56.818 -18.135 17.531  1    39.89  ? 382 TYR D CA  1 
ATOM   8398 C  C   . TYR D 2 212 ? -58.141 -18.914 17.545  1    38.95  ? 382 TYR D C   1 
ATOM   8399 O  O   . TYR D 2 212 ? -59.1   -18.512 18.218  1    39.45  ? 382 TYR D O   1 
ATOM   8400 C  CB  . TYR D 2 212 ? -56.191 -18.18  18.931  1    36.19  ? 382 TYR D CB  1 
ATOM   8401 C  CG  . TYR D 2 212 ? -54.762 -17.678 19.069  1    38.53  ? 382 TYR D CG  1 
ATOM   8402 C  CD1 . TYR D 2 212 ? -53.885 -17.67  17.99   1    38.5   ? 382 TYR D CD1 1 
ATOM   8403 C  CD2 . TYR D 2 212 ? -54.293 -17.194 20.288  1    39.7   ? 382 TYR D CD2 1 
ATOM   8404 C  CE1 . TYR D 2 212 ? -52.591 -17.184 18.115  1    38.24  ? 382 TYR D CE1 1 
ATOM   8405 C  CE2 . TYR D 2 212 ? -53.001 -16.704 20.422  1    43.1   ? 382 TYR D CE2 1 
ATOM   8406 C  CZ  . TYR D 2 212 ? -52.141 -16.705 19.333  1    41.03  ? 382 TYR D CZ  1 
ATOM   8407 O  OH  . TYR D 2 212 ? -50.852 -16.262 19.452  1    33.99  ? 382 TYR D OH  1 
ATOM   8408 N  N   . THR D 2 213 ? -58.173 -20.046 16.823  1    34.73  ? 383 THR D N   1 
ATOM   8409 C  CA  . THR D 2 213 ? -59.309 -20.954 16.89   1    38.56  ? 383 THR D CA  1 
ATOM   8410 C  C   . THR D 2 213 ? -58.947 -22.113 17.813  1    41.14  ? 383 THR D C   1 
ATOM   8411 O  O   . THR D 2 213 ? -57.784 -22.275 18.178  1    42.64  ? 383 THR D O   1 
ATOM   8412 C  CB  . THR D 2 213 ? -59.765 -21.417 15.502  1    36.67  ? 383 THR D CB  1 
ATOM   8413 O  OG1 . THR D 2 213 ? -58.845 -22.377 14.998  1    39.32  ? 383 THR D OG1 1 
ATOM   8414 C  CG2 . THR D 2 213 ? -59.897 -20.275 14.509  1    35.57  ? 383 THR D CG2 1 
ATOM   8415 N  N   . LEU D 2 214 ? -59.957 -22.898 18.206  1    45.28  ? 384 LEU D N   1 
ATOM   8416 C  CA  . LEU D 2 214 ? -59.738 -24.088 19.013  1    44.47  ? 384 LEU D CA  1 
ATOM   8417 C  C   . LEU D 2 214 ? -58.806 -25.035 18.261  1    42.5   ? 384 LEU D C   1 
ATOM   8418 O  O   . LEU D 2 214 ? -57.96  -25.686 18.863  1    42.79  ? 384 LEU D O   1 
ATOM   8419 C  CB  . LEU D 2 214 ? -61.059 -24.741 19.43   1    40.79  ? 384 LEU D CB  1 
ATOM   8420 C  CG  . LEU D 2 214 ? -61.788 -24.062 20.597  1    40.4   ? 384 LEU D CG  1 
ATOM   8421 C  CD1 . LEU D 2 214 ? -63.093 -24.702 20.976  1    35.32  ? 384 LEU D CD1 1 
ATOM   8422 C  CD2 . LEU D 2 214 ? -60.89  -23.993 21.826  1    46.45  ? 384 LEU D CD2 1 
ATOM   8423 N  N   . GLU D 2 215 ? -58.917 -25.038 16.932  1    41.53  ? 385 GLU D N   1 
ATOM   8424 C  CA  . GLU D 2 215 ? -58.094 -25.894 16.098  1    43.93  ? 385 GLU D CA  1 
ATOM   8425 C  C   . GLU D 2 215 ? -56.611 -25.553 16.266  1    43.14  ? 385 GLU D C   1 
ATOM   8426 O  O   . GLU D 2 215 ? -55.777 -26.442 16.411  1    45.75  ? 385 GLU D O   1 
ATOM   8427 C  CB  . GLU D 2 215 ? -58.55  -25.81  14.641  1    46.85  ? 385 GLU D CB  1 
ATOM   8428 C  CG  . GLU D 2 215 ? -58.345 -27.132 13.906  1    54.99  ? 385 GLU D CG  1 
ATOM   8429 C  CD  . GLU D 2 215 ? -58.566 -27.046 12.413  1    62.09  ? 385 GLU D CD  1 
ATOM   8430 O  OE1 . GLU D 2 215 ? -59.389 -27.826 11.892  1    65.77  ? 385 GLU D OE1 1 
ATOM   8431 O  OE2 . GLU D 2 215 ? -57.91  -26.18  11.794  1    67.98  ? 385 GLU D OE2 1 
ATOM   8432 N  N   . THR D 2 216 ? -56.329 -24.249 16.332  1    39.5   ? 386 THR D N   1 
ATOM   8433 C  CA  . THR D 2 216 ? -54.934 -23.772 16.421  1    41.8   ? 386 THR D CA  1 
ATOM   8434 C  C   . THR D 2 216 ? -54.413 -23.898 17.833  1    39.12  ? 386 THR D C   1 
ATOM   8435 O  O   . THR D 2 216 ? -53.184 -23.921 18.004  1    36.19  ? 386 THR D O   1 
ATOM   8436 C  CB  . THR D 2 216 ? -54.925 -22.323 15.946  1    44.98  ? 386 THR D CB  1 
ATOM   8437 O  OG1 . THR D 2 216 ? -55.743 -21.623 16.877  1    48.35  ? 386 THR D OG1 1 
ATOM   8438 C  CG2 . THR D 2 216 ? -55.5   -22.169 14.551  1    38.01  ? 386 THR D CG2 1 
ATOM   8439 N  N   . LEU D 2 217 ? -55.309 -23.977 18.811  1    34.97  ? 387 LEU D N   1 
ATOM   8440 C  CA  . LEU D 2 217 ? -54.889 -24.053 20.227  1    29.92  ? 387 LEU D CA  1 
ATOM   8441 C  C   . LEU D 2 217 ? -54.923 -25.508 20.691  1    33.92  ? 387 LEU D C   1 
ATOM   8442 O  O   . LEU D 2 217 ? -54.857 -25.731 21.905  1    34.57  ? 387 LEU D O   1 
ATOM   8443 C  CB  . LEU D 2 217 ? -55.838 -23.193 21.054  1    25.88  ? 387 LEU D CB  1 
ATOM   8444 C  CG  . LEU D 2 217 ? -55.906 -21.709 20.691  1    23.32  ? 387 LEU D CG  1 
ATOM   8445 C  CD1 . LEU D 2 217 ? -57.061 -21.081 21.445  1    23.13  ? 387 LEU D CD1 1 
ATOM   8446 C  CD2 . LEU D 2 217 ? -54.6   -21.02  21.023  1    22.76  ? 387 LEU D CD2 1 
ATOM   8447 N  N   . LYS D 2 218 ? -55.004 -26.456 19.763  1    34.3   ? 388 LYS D N   1 
ATOM   8448 C  CA  . LYS D 2 218 ? -55.156 -27.88  20.159  1    37.85  ? 388 LYS D CA  1 
ATOM   8449 C  C   . LYS D 2 218 ? -53.832 -28.45  20.694  1    39.85  ? 388 LYS D C   1 
ATOM   8450 O  O   . LYS D 2 218 ? -53.85  -28.975 21.816  1    42.22  ? 388 LYS D O   1 
ATOM   8451 C  CB  . LYS D 2 218 ? -55.729 -28.705 18.999  1    40.04  ? 388 LYS D CB  1 
ATOM   8452 C  CG  . LYS D 2 218 ? -55.572 -30.21  19.127  1    41.68  ? 388 LYS D CG  1 
ATOM   8453 C  CD  . LYS D 2 218 ? -56.589 -30.98  18.297  1    45.03  ? 388 LYS D CD  1 
ATOM   8454 C  CE  . LYS D 2 218 ? -56.407 -30.764 16.831  1    43.4   ? 388 LYS D CE  1 
ATOM   8455 N  NZ  . LYS D 2 218 ? -56.845 -31.931 16.063  1    37.32  ? 388 LYS D NZ  1 
ATOM   8456 N  N   . PRO D 2 219 ? -52.694 -28.394 19.975  1    39.31  ? 389 PRO D N   1 
ATOM   8457 C  CA  . PRO D 2 219 ? -51.461 -28.91  20.541  1    40.58  ? 389 PRO D CA  1 
ATOM   8458 C  C   . PRO D 2 219 ? -51.273 -28.498 21.99   1    45.12  ? 389 PRO D C   1 
ATOM   8459 O  O   . PRO D 2 219 ? -51.05  -29.378 22.841  1    46.47  ? 389 PRO D O   1 
ATOM   8460 C  CB  . PRO D 2 219 ? -50.433 -28.273 19.62   1    38.03  ? 389 PRO D CB  1 
ATOM   8461 C  CG  . PRO D 2 219 ? -51.116 -28.253 18.28   1    36.21  ? 389 PRO D CG  1 
ATOM   8462 C  CD  . PRO D 2 219 ? -52.533 -27.858 18.629  1    36.39  ? 389 PRO D CD  1 
ATOM   8463 N  N   . CYS D 2 220 ? -51.351 -27.193 22.268  1    43.21  ? 390 CYS D N   1 
ATOM   8464 C  CA  . CYS D 2 220 ? -51.131 -26.688 23.648  1    38.7   ? 390 CYS D CA  1 
ATOM   8465 C  C   . CYS D 2 220 ? -52.212 -27.256 24.571  1    35.79  ? 390 CYS D C   1 
ATOM   8466 O  O   . CYS D 2 220 ? -51.857 -27.757 25.645  1    31.91  ? 390 CYS D O   1 
ATOM   8467 C  CB  . CYS D 2 220 ? -51.122 -25.164 23.694  1    44.28  ? 390 CYS D CB  1 
ATOM   8468 S  SG  . CYS D 2 220 ? -50.54  -24.49  25.269  1    42.36  ? 390 CYS D SG  1 
ATOM   8469 N  N   . LEU D 2 221 ? -53.472 -27.192 24.146  1    36.76  ? 391 LEU D N   1 
ATOM   8470 C  CA  . LEU D 2 221 ? -54.589 -27.709 24.973  1    39.9   ? 391 LEU D CA  1 
ATOM   8471 C  C   . LEU D 2 221 ? -54.315 -29.175 25.341  1    39.85  ? 391 LEU D C   1 
ATOM   8472 O  O   . LEU D 2 221 ? -54.58  -29.556 26.494  1    40.49  ? 391 LEU D O   1 
ATOM   8473 C  CB  . LEU D 2 221 ? -55.893 -27.551 24.2    1    41.45  ? 391 LEU D CB  1 
ATOM   8474 C  CG  . LEU D 2 221 ? -57.156 -28.098 24.87   1    43.56  ? 391 LEU D CG  1 
ATOM   8475 C  CD1 . LEU D 2 221 ? -57.468 -27.38  26.168  1    44.88  ? 391 LEU D CD1 1 
ATOM   8476 C  CD2 . LEU D 2 221 ? -58.332 -28.032 23.915  1    45.93  ? 391 LEU D CD2 1 
ATOM   8477 N  N   . LEU D 2 222 ? -53.799 -29.953 24.393  1    38.28  ? 392 LEU D N   1 
ATOM   8478 C  CA  . LEU D 2 222 ? -53.518 -31.384 24.654  1    41.93  ? 392 LEU D CA  1 
ATOM   8479 C  C   . LEU D 2 222 ? -52.443 -31.503 25.739  1    43.75  ? 392 LEU D C   1 
ATOM   8480 O  O   . LEU D 2 222 ? -52.707 -32.15  26.768  1    43.85  ? 392 LEU D O   1 
ATOM   8481 C  CB  . LEU D 2 222 ? -53.078 -32.055 23.356  1    36.6   ? 392 LEU D CB  1 
ATOM   8482 C  CG  . LEU D 2 222 ? -54.162 -32.23  22.291  1    37.5   ? 392 LEU D CG  1 
ATOM   8483 C  CD1 . LEU D 2 222 ? -53.591 -32.928 21.073  1    35.97  ? 392 LEU D CD1 1 
ATOM   8484 C  CD2 . LEU D 2 222 ? -55.338 -33.004 22.856  1    36.19  ? 392 LEU D CD2 1 
ATOM   8485 N  N   . ASP D 2 223 ? -51.277 -30.904 25.502  1    43.78  ? 393 ASP D N   1 
ATOM   8486 C  CA  . ASP D 2 223 ? -50.177 -30.938 26.5    1    40.7   ? 393 ASP D CA  1 
ATOM   8487 C  C   . ASP D 2 223 ? -50.707 -30.399 27.826  1    43.04  ? 393 ASP D C   1 
ATOM   8488 O  O   . ASP D 2 223 ? -50.366 -30.972 28.875  1    45.85  ? 393 ASP D O   1 
ATOM   8489 C  CB  . ASP D 2 223 ? -48.969 -30.161 26.009  1    37.26  ? 393 ASP D CB  1 
ATOM   8490 C  CG  . ASP D 2 223 ? -48.224 -30.756 24.825  1    41.21  ? 393 ASP D CG  1 
ATOM   8491 O  OD1 . ASP D 2 223 ? -48.136 -31.997 24.754  1    48.62  ? 393 ASP D OD1 1 
ATOM   8492 O  OD2 . ASP D 2 223 ? -47.729 -29.972 23.995  1    39.2   ? 393 ASP D OD2 1 
ATOM   8493 N  N   . LEU D 2 224 ? -51.514 -29.341 27.779  1    40.26  ? 394 LEU D N   1 
ATOM   8494 C  CA  . LEU D 2 224 ? -52.003 -28.708 29.028  1    37.51  ? 394 LEU D CA  1 
ATOM   8495 C  C   . LEU D 2 224 ? -52.96  -29.67  29.734  1    38.23  ? 394 LEU D C   1 
ATOM   8496 O  O   . LEU D 2 224 ? -52.834 -29.845 30.959  1    38.05  ? 394 LEU D O   1 
ATOM   8497 C  CB  . LEU D 2 224 ? -52.668 -27.373 28.711  1    37.12  ? 394 LEU D CB  1 
ATOM   8498 C  CG  . LEU D 2 224 ? -52.847 -26.417 29.894  1    38.68  ? 394 LEU D CG  1 
ATOM   8499 C  CD1 . LEU D 2 224 ? -51.62  -26.407 30.786  1    38.35  ? 394 LEU D CD1 1 
ATOM   8500 C  CD2 . LEU D 2 224 ? -53.143 -25.021 29.392  1    33.42  ? 394 LEU D CD2 1 
ATOM   8501 N  N   . HIS D 2 225 ? -53.876 -30.261 28.979  1    38.6   ? 395 HIS D N   1 
ATOM   8502 C  CA  . HIS D 2 225 ? -54.781 -31.261 29.588  1    38.66  ? 395 HIS D CA  1 
ATOM   8503 C  C   . HIS D 2 225 ? -53.938 -32.323 30.271  1    36.8   ? 395 HIS D C   1 
ATOM   8504 O  O   . HIS D 2 225 ? -54.223 -32.701 31.414  1    40.26  ? 395 HIS D O   1 
ATOM   8505 C  CB  . HIS D 2 225 ? -55.639 -31.939 28.52   1    42.99  ? 395 HIS D CB  1 
ATOM   8506 C  CG  . HIS D 2 225 ? -56.828 -32.641 29.075  1    40.41  ? 395 HIS D CG  1 
ATOM   8507 N  ND1 . HIS D 2 225 ? -57.513 -32.163 30.168  1    37.75  ? 395 HIS D ND1 1 
ATOM   8508 C  CD2 . HIS D 2 225 ? -57.451 -33.762 28.707  1    34.8   ? 395 HIS D CD2 1 
ATOM   8509 C  CE1 . HIS D 2 225 ? -58.517 -32.978 30.441  1    34.65  ? 395 HIS D CE1 1 
ATOM   8510 N  NE2 . HIS D 2 225 ? -58.498 -33.955 29.567  1    35.84  ? 395 HIS D NE2 1 
ATOM   8511 N  N   . GLN D 2 226 ? -52.893 -32.766 29.586  1    35.85  ? 396 GLN D N   1 
ATOM   8512 C  CA  . GLN D 2 226 ? -52.132 -33.879 30.139  1    38.57  ? 396 GLN D CA  1 
ATOM   8513 C  C   . GLN D 2 226 ? -51.404 -33.403 31.401  1    39.68  ? 396 GLN D C   1 
ATOM   8514 O  O   . GLN D 2 226 ? -51.285 -34.138 32.378  1    44.73  ? 396 GLN D O   1 
ATOM   8515 C  CB  . GLN D 2 226 ? -51.233 -34.483 29.053  1    36.46  ? 396 GLN D CB  1 
ATOM   8516 C  CG  . GLN D 2 226 ? -50.958 -35.979 29.189  1    44.03  ? 396 GLN D CG  1 
ATOM   8517 C  CD  . GLN D 2 226 ? -52.209 -36.856 29.177  1    54.78  ? 396 GLN D CD  1 
ATOM   8518 O  OE1 . GLN D 2 226 ? -53.22  -36.563 28.522  1    52.66  ? 396 GLN D OE1 1 
ATOM   8519 N  NE2 . GLN D 2 226 ? -52.179 -37.963 29.91   1    53.37  ? 396 GLN D NE2 1 
ATOM   8520 N  N   . THR D 2 227 ? -50.973 -32.139 31.398  1    36.7   ? 397 THR D N   1 
ATOM   8521 C  CA  . THR D 2 227 ? -50.308 -31.556 32.554  1    38.38  ? 397 THR D CA  1 
ATOM   8522 C  C   . THR D 2 227 ? -51.276 -31.505 33.734  1    39.11  ? 397 THR D C   1 
ATOM   8523 O  O   . THR D 2 227 ? -50.894 -31.804 34.869  1    41.48  ? 397 THR D O   1 
ATOM   8524 C  CB  . THR D 2 227 ? -49.739 -30.168 32.242  1    34.07  ? 397 THR D CB  1 
ATOM   8525 O  OG1 . THR D 2 227 ? -48.93  -30.25  31.073  1    31.61  ? 397 THR D OG1 1 
ATOM   8526 C  CG2 . THR D 2 227 ? -48.897 -29.632 33.383  1    33.58  ? 397 THR D CG2 1 
ATOM   8527 N  N   . TYR D 2 228 ? -52.531 -31.134 33.448  1    35.04  ? 398 TYR D N   1 
ATOM   8528 C  CA  . TYR D 2 228 ? -53.514 -30.89  34.492  1    34.86  ? 398 TYR D CA  1 
ATOM   8529 C  C   . TYR D 2 228 ? -53.866 -32.212 35.156  1    38.73  ? 398 TYR D C   1 
ATOM   8530 O  O   . TYR D 2 228 ? -54.185 -32.242 36.35   1    40.29  ? 398 TYR D O   1 
ATOM   8531 C  CB  . TYR D 2 228 ? -54.737 -30.204 33.88   1    33.98  ? 398 TYR D CB  1 
ATOM   8532 C  CG  . TYR D 2 228 ? -55.831 -29.753 34.837  1    34.82  ? 398 TYR D CG  1 
ATOM   8533 C  CD1 . TYR D 2 228 ? -55.672 -29.799 36.223  1    35.67  ? 398 TYR D CD1 1 
ATOM   8534 C  CD2 . TYR D 2 228 ? -57.021 -29.238 34.336  1    33.17  ? 398 TYR D CD2 1 
ATOM   8535 C  CE1 . TYR D 2 228 ? -56.674 -29.355 37.076  1    36.37  ? 398 TYR D CE1 1 
ATOM   8536 C  CE2 . TYR D 2 228 ? -58.028 -28.794 35.18   1    33.81  ? 398 TYR D CE2 1 
ATOM   8537 C  CZ  . TYR D 2 228 ? -57.856 -28.85  36.554  1    34.83  ? 398 TYR D CZ  1 
ATOM   8538 O  OH  . TYR D 2 228 ? -58.854 -28.404 37.377  1    31.1   ? 398 TYR D OH  1 
ATOM   8539 N  N   . LEU D 2 229 ? -53.833 -33.281 34.344  1    41.91  ? 399 LEU D N   1 
ATOM   8540 C  CA  . LEU D 2 229 ? -54.243 -34.62  34.741  1    41.11  ? 399 LEU D CA  1 
ATOM   8541 C  C   . LEU D 2 229 ? -53.153 -35.236 35.613  1    43.34  ? 399 LEU D C   1 
ATOM   8542 O  O   . LEU D 2 229 ? -53.45  -35.888 36.608  1    40.25  ? 399 LEU D O   1 
ATOM   8543 C  CB  . LEU D 2 229 ? -54.545 -35.476 33.51   1    34.16  ? 399 LEU D CB  1 
ATOM   8544 C  CG  . LEU D 2 229 ? -55.883 -35.236 32.796  1    29.9   ? 399 LEU D CG  1 
ATOM   8545 C  CD1 . LEU D 2 229 ? -55.948 -35.979 31.478  1    25.74  ? 399 LEU D CD1 1 
ATOM   8546 C  CD2 . LEU D 2 229 ? -57.057 -35.636 33.655  1    27.38  ? 399 LEU D CD2 1 
ATOM   8547 N  N   . ARG D 2 230 ? -51.89  -34.992 35.247  1    44.09  ? 400 ARG D N   1 
ATOM   8548 C  CA  . ARG D 2 230 ? -50.762 -35.624 35.912  1    46.95  ? 400 ARG D CA  1 
ATOM   8549 C  C   . ARG D 2 230 ? -50.283 -34.776 37.089  1    45.66  ? 400 ARG D C   1 
ATOM   8550 O  O   . ARG D 2 230 ? -49.328 -35.156 37.76   1    43.89  ? 400 ARG D O   1 
ATOM   8551 C  CB  . ARG D 2 230 ? -49.654 -35.88  34.885  1    50.02  ? 400 ARG D CB  1 
ATOM   8552 C  CG  . ARG D 2 230 ? -50.075 -36.945 33.882  1    58.9   ? 400 ARG D CG  1 
ATOM   8553 C  CD  . ARG D 2 230 ? -49.407 -36.848 32.519  1    63.93  ? 400 ARG D CD  1 
ATOM   8554 N  NE  . ARG D 2 230 ? -49.754 -38.025 31.713  1    70.34  ? 400 ARG D NE  1 
ATOM   8555 C  CZ  . ARG D 2 230 ? -48.916 -38.71  30.934  1    72.19  ? 400 ARG D CZ  1 
ATOM   8556 N  NH1 . ARG D 2 230 ? -47.721 -38.196 30.665  1    73.21  ? 400 ARG D NH1 1 
ATOM   8557 N  NH2 . ARG D 2 230 ? -49.3   -39.874 30.408  1    56.35  ? 400 ARG D NH2 1 
ATOM   8558 N  N   . ALA D 2 231 ? -50.988 -33.667 37.351  1    42.37  ? 401 ALA D N   1 
ATOM   8559 C  CA  . ALA D 2 231 ? -50.547 -32.644 38.283  1    42.56  ? 401 ALA D CA  1 
ATOM   8560 C  C   . ALA D 2 231 ? -50.281 -33.191 39.689  1    42.08  ? 401 ALA D C   1 
ATOM   8561 O  O   . ALA D 2 231 ? -49.243 -32.881 40.26   1    52.08  ? 401 ALA D O   1 
ATOM   8562 C  CB  . ALA D 2 231 ? -51.519 -31.49  38.291  1    41.96  ? 401 ALA D CB  1 
ATOM   8563 N  N   . PRO D 2 232 ? -51.184 -33.981 40.321  1    39.84  ? 402 PRO D N   1 
ATOM   8564 C  CA  . PRO D 2 232 ? -50.912 -34.537 41.651  1    35.99  ? 402 PRO D CA  1 
ATOM   8565 C  C   . PRO D 2 232 ? -49.69  -35.442 41.797  1    38.67  ? 402 PRO D C   1 
ATOM   8566 O  O   . PRO D 2 232 ? -49.283 -35.723 42.922  1    37.13  ? 402 PRO D O   1 
ATOM   8567 C  CB  . PRO D 2 232 ? -52.195 -35.308 41.976  1    31.81  ? 402 PRO D CB  1 
ATOM   8568 C  CG  . PRO D 2 232 ? -53.253 -34.659 41.132  1    31.43  ? 402 PRO D CG  1 
ATOM   8569 C  CD  . PRO D 2 232 ? -52.534 -34.328 39.839  1    35.36  ? 402 PRO D CD  1 
ATOM   8570 N  N   . GLN D 2 233 ? -49.135 -35.925 40.669  1    42.34  ? 403 GLN D N   1 
ATOM   8571 C  CA  . GLN D 2 233 ? -47.964 -36.802 40.658  1    40.81  ? 403 GLN D CA  1 
ATOM   8572 C  C   . GLN D 2 233 ? -46.677 -36.066 40.278  1    37.99  ? 403 GLN D C   1 
ATOM   8573 O  O   . GLN D 2 233 ? -45.603 -36.656 40.391  1    33.72  ? 403 GLN D O   1 
ATOM   8574 C  CB  . GLN D 2 233 ? -48.071 -37.977 39.681  1    43.2   ? 403 GLN D CB  1 
ATOM   8575 C  CG  . GLN D 2 233 ? -48.688 -39.254 40.242  1    39.57  ? 403 GLN D CG  1 
ATOM   8576 C  CD  . GLN D 2 233 ? -50.171 -39.128 40.5    1    40.86  ? 403 GLN D CD  1 
ATOM   8577 O  OE1 . GLN D 2 233 ? -50.676 -39.499 41.565  1    45.96  ? 403 GLN D OE1 1 
ATOM   8578 N  NE2 . GLN D 2 233 ? -50.893 -38.629 39.511  1    39.13  ? 403 GLN D NE2 1 
ATOM   8579 N  N   . HIS D 2 234 ? -46.784 -34.8   39.824  1    36.92  ? 404 HIS D N   1 
ATOM   8580 C  CA  . HIS D 2 234 ? -45.636 -33.992 39.433  1    33.96  ? 404 HIS D CA  1 
ATOM   8581 C  C   . HIS D 2 234 ? -44.665 -33.859 40.61   1    30.14  ? 404 HIS D C   1 
ATOM   8582 O  O   . HIS D 2 234 ? -45.078 -33.658 41.746  1    29.4   ? 404 HIS D O   1 
ATOM   8583 C  CB  . HIS D 2 234 ? -46.094 -32.629 38.897  1    40.74  ? 404 HIS D CB  1 
ATOM   8584 C  CG  . HIS D 2 234 ? -45.059 -31.965 38.033  1    46     ? 404 HIS D CG  1 
ATOM   8585 N  ND1 . HIS D 2 234 ? -43.779 -31.652 38.456  1    43.72  ? 404 HIS D ND1 1 
ATOM   8586 C  CD2 . HIS D 2 234 ? -45.137 -31.553 36.758  1    44.98  ? 404 HIS D CD2 1 
ATOM   8587 C  CE1 . HIS D 2 234 ? -43.106 -31.105 37.461  1    41.3   ? 404 HIS D CE1 1 
ATOM   8588 N  NE2 . HIS D 2 234 ? -43.911 -31.042 36.415  1    45.94  ? 404 HIS D NE2 1 
ATOM   8589 N  N   . ALA D 2 235 ? -43.364 -33.957 40.338  1    27.7   ? 405 ALA D N   1 
ATOM   8590 C  CA  . ALA D 2 235 ? -42.379 -33.849 41.401  1    30.04  ? 405 ALA D CA  1 
ATOM   8591 C  C   . ALA D 2 235 ? -42.578 -32.538 42.16   1    35.43  ? 405 ALA D C   1 
ATOM   8592 O  O   . ALA D 2 235 ? -42.276 -32.49  43.35   1    38.63  ? 405 ALA D O   1 
ATOM   8593 C  CB  . ALA D 2 235 ? -40.971 -33.976 40.848  1    26.99  ? 405 ALA D CB  1 
ATOM   8594 N  N   . GLN D 2 236 ? -43.122 -31.509 41.479  1    37.22  ? 406 GLN D N   1 
ATOM   8595 C  CA  . GLN D 2 236 ? -43.292 -30.156 42.014  1    42.81  ? 406 GLN D CA  1 
ATOM   8596 C  C   . GLN D 2 236 ? -44.758 -29.849 42.331  1    44.12  ? 406 GLN D C   1 
ATOM   8597 O  O   . GLN D 2 236 ? -45.642 -30.052 41.494  1    49.38  ? 406 GLN D O   1 
ATOM   8598 C  CB  . GLN D 2 236 ? -42.737 -29.105 41.055  1    41.18  ? 406 GLN D CB  1 
ATOM   8599 C  CG  . GLN D 2 236 ? -41.237 -28.88  41.207  1    46.92  ? 406 GLN D CG  1 
ATOM   8600 C  CD  . GLN D 2 236 ? -40.386 -30.029 40.706  1    56.7   ? 406 GLN D CD  1 
ATOM   8601 O  OE1 . GLN D 2 236 ? -40.649 -30.604 39.64   1    69.11  ? 406 GLN D OE1 1 
ATOM   8602 N  NE2 . GLN D 2 236 ? -39.35  -30.363 41.467  1    50.17  ? 406 GLN D NE2 1 
ATOM   8603 N  N   . GLN D 2 237 ? -44.991 -29.307 43.535  1    40.47  ? 407 GLN D N   1 
ATOM   8604 C  CA  . GLN D 2 237 ? -46.317 -29.289 44.13   1    40.42  ? 407 GLN D CA  1 
ATOM   8605 C  C   . GLN D 2 237 ? -46.759 -27.89  44.559  1    41.99  ? 407 GLN D C   1 
ATOM   8606 O  O   . GLN D 2 237 ? -47.93  -27.708 44.902  1    41.91  ? 407 GLN D O   1 
ATOM   8607 C  CB  . GLN D 2 237 ? -46.326 -30.208 45.352  1    39.43  ? 407 GLN D CB  1 
ATOM   8608 C  CG  . GLN D 2 237 ? -46.449 -31.69  45.021  1    37.57  ? 407 GLN D CG  1 
ATOM   8609 C  CD  . GLN D 2 237 ? -47.594 -31.954 44.074  1    34.58  ? 407 GLN D CD  1 
ATOM   8610 O  OE1 . GLN D 2 237 ? -48.707 -31.448 44.245  1    33.62  ? 407 GLN D OE1 1 
ATOM   8611 N  NE2 . GLN D 2 237 ? -47.312 -32.698 43.021  1    35.88  ? 407 GLN D NE2 1 
ATOM   8612 N  N   . SER D 2 238 ? -45.838 -26.916 44.547  1    41.72  ? 408 SER D N   1 
ATOM   8613 C  CA  . SER D 2 238 ? -46.04  -25.63  45.207  1    37.94  ? 408 SER D CA  1 
ATOM   8614 C  C   . SER D 2 238 ? -47.252 -24.885 44.651  1    35.65  ? 408 SER D C   1 
ATOM   8615 O  O   . SER D 2 238 ? -47.973 -24.228 45.405  1    35.98  ? 408 SER D O   1 
ATOM   8616 C  CB  . SER D 2 238 ? -44.803 -24.791 45.172  1    34.03  ? 408 SER D CB  1 
ATOM   8617 O  OG  . SER D 2 238 ? -43.746 -25.422 45.879  1    32.04  ? 408 SER D OG  1 
ATOM   8618 N  N   . ILE D 2 239 ? -47.495 -25.04  43.346  1    34.94  ? 409 ILE D N   1 
ATOM   8619 C  CA  . ILE D 2 239 ? -48.63  -24.402 42.701  1    34.96  ? 409 ILE D CA  1 
ATOM   8620 C  C   . ILE D 2 239 ? -49.937 -25.035 43.161  1    37.1   ? 409 ILE D C   1 
ATOM   8621 O  O   . ILE D 2 239 ? -50.908 -24.331 43.452  1    41.69  ? 409 ILE D O   1 
ATOM   8622 C  CB  . ILE D 2 239 ? -48.491 -24.438 41.178  1    33.11  ? 409 ILE D CB  1 
ATOM   8623 C  CG1 . ILE D 2 239 ? -47.129 -23.854 40.756  1    32.93  ? 409 ILE D CG1 1 
ATOM   8624 C  CG2 . ILE D 2 239 ? -49.647 -23.672 40.545  1    29.72  ? 409 ILE D CG2 1 
ATOM   8625 C  CD1 . ILE D 2 239 ? -46.799 -23.965 39.278  1    29.56  ? 409 ILE D CD1 1 
ATOM   8626 N  N   . ARG D 2 240 ? -49.962 -26.365 43.231  1    35.97  ? 410 ARG D N   1 
ATOM   8627 C  CA  . ARG D 2 240 ? -51.158 -27.051 43.696  1    37.07  ? 410 ARG D CA  1 
ATOM   8628 C  C   . ARG D 2 240 ? -51.464 -26.69  45.151  1    40.06  ? 410 ARG D C   1 
ATOM   8629 O  O   . ARG D 2 240 ? -52.635 -26.525 45.492  1    44.24  ? 410 ARG D O   1 
ATOM   8630 C  CB  . ARG D 2 240 ? -51.06  -28.569 43.517  1    37.7   ? 410 ARG D CB  1 
ATOM   8631 C  CG  . ARG D 2 240 ? -51.33  -29.097 42.117  1    35.83  ? 410 ARG D CG  1 
ATOM   8632 C  CD  . ARG D 2 240 ? -51.302 -30.627 42.092  1    38.5   ? 410 ARG D CD  1 
ATOM   8633 N  NE  . ARG D 2 240 ? -52.503 -31.279 42.639  1    36.57  ? 410 ARG D NE  1 
ATOM   8634 C  CZ  . ARG D 2 240 ? -52.57  -31.953 43.781  1    34.78  ? 410 ARG D CZ  1 
ATOM   8635 N  NH1 . ARG D 2 240 ? -53.704 -32.487 44.17   1    32.7   ? 410 ARG D NH1 1 
ATOM   8636 N  NH2 . ARG D 2 240 ? -51.511 -32.09  44.551  1    35.41  ? 410 ARG D NH2 1 
ATOM   8637 N  N   . GLU D 2 241 ? -50.426 -26.603 46.006  1    39.35  ? 411 GLU D N   1 
ATOM   8638 C  CA  . GLU D 2 241 ? -50.577 -26.166 47.391  1    39.01  ? 411 GLU D CA  1 
ATOM   8639 C  C   . GLU D 2 241 ? -51.12  -24.74  47.425  1    39.63  ? 411 GLU D C   1 
ATOM   8640 O  O   . GLU D 2 241 ? -51.915 -24.41  48.304  1    39.41  ? 411 GLU D O   1 
ATOM   8641 C  CB  . GLU D 2 241 ? -49.259 -26.051 48.162  1    44.01  ? 411 GLU D CB  1 
ATOM   8642 C  CG  . GLU D 2 241 ? -48.434 -27.333 48.261  1    53.45  ? 411 GLU D CG  1 
ATOM   8643 C  CD  . GLU D 2 241 ? -49.074 -28.527 48.961  1    67.44  ? 411 GLU D CD  1 
ATOM   8644 O  OE1 . GLU D 2 241 ? -50.217 -28.43  49.508  1    65.6   ? 411 GLU D OE1 1 
ATOM   8645 O  OE2 . GLU D 2 241 ? -48.398 -29.595 48.93   1    73.22  ? 411 GLU D OE2 1 
ATOM   8646 N  N   . LYS D 2 242 ? -50.653 -23.913 46.476  1    40.83  ? 412 LYS D N   1 
ATOM   8647 C  CA  . LYS D 2 242 ? -50.881 -22.477 46.478  1    40.04  ? 412 LYS D CA  1 
ATOM   8648 C  C   . LYS D 2 242 ? -52.342 -22.189 46.175  1    40.16  ? 412 LYS D C   1 
ATOM   8649 O  O   . LYS D 2 242 ? -52.936 -21.348 46.838  1    46.01  ? 412 LYS D O   1 
ATOM   8650 C  CB  . LYS D 2 242 ? -49.958 -21.787 45.468  1    39.02  ? 412 LYS D CB  1 
ATOM   8651 C  CG  . LYS D 2 242 ? -50.292 -20.337 45.122  1    35.18  ? 412 LYS D CG  1 
ATOM   8652 C  CD  . LYS D 2 242 ? -49.314 -19.72  44.132  1    33.59  ? 412 LYS D CD  1 
ATOM   8653 C  CE  . LYS D 2 242 ? -49.588 -18.3   43.734  1    29.82  ? 412 LYS D CE  1 
ATOM   8654 N  NZ  . LYS D 2 242 ? -48.767 -17.894 42.585  1    25.65  ? 412 LYS D NZ  1 
ATOM   8655 N  N   . TYR D 2 243 ? -52.888 -22.898 45.177  1    43.66  ? 413 TYR D N   1 
ATOM   8656 C  CA  . TYR D 2 243 ? -54.242 -22.682 44.675  1    43.92  ? 413 TYR D CA  1 
ATOM   8657 C  C   . TYR D 2 243 ? -55.265 -23.615 45.337  1    44.5   ? 413 TYR D C   1 
ATOM   8658 O  O   . TYR D 2 243 ? -56.391 -23.735 44.855  1    41.35  ? 413 TYR D O   1 
ATOM   8659 C  CB  . TYR D 2 243 ? -54.262 -22.855 43.152  1    44.94  ? 413 TYR D CB  1 
ATOM   8660 C  CG  . TYR D 2 243 ? -53.685 -21.699 42.354  1    45     ? 413 TYR D CG  1 
ATOM   8661 C  CD1 . TYR D 2 243 ? -52.313 -21.48  42.298  1    51.11  ? 413 TYR D CD1 1 
ATOM   8662 C  CD2 . TYR D 2 243 ? -54.511 -20.833 41.647  1    44.62  ? 413 TYR D CD2 1 
ATOM   8663 C  CE1 . TYR D 2 243 ? -51.781 -20.417 41.577  1    47.28  ? 413 TYR D CE1 1 
ATOM   8664 C  CE2 . TYR D 2 243 ? -53.992 -19.772 40.919  1    44.05  ? 413 TYR D CE2 1 
ATOM   8665 C  CZ  . TYR D 2 243 ? -52.624 -19.563 40.884  1    42.79  ? 413 TYR D CZ  1 
ATOM   8666 O  OH  . TYR D 2 243 ? -52.114 -18.534 40.163  1    38.64  ? 413 TYR D OH  1 
ATOM   8667 N  N   . LYS D 2 244 ? -54.88  -24.29  46.428  1    46.82  ? 414 LYS D N   1 
ATOM   8668 C  CA  . LYS D 2 244 ? -55.844 -24.863 47.36   1    46.53  ? 414 LYS D CA  1 
ATOM   8669 C  C   . LYS D 2 244 ? -56.474 -23.73  48.155  1    48.62  ? 414 LYS D C   1 
ATOM   8670 O  O   . LYS D 2 244 ? -57.676 -23.743 48.415  1    51.18  ? 414 LYS D O   1 
ATOM   8671 C  CB  . LYS D 2 244 ? -55.182 -25.784 48.389  1    44.31  ? 414 LYS D CB  1 
ATOM   8672 C  CG  . LYS D 2 244 ? -54.753 -27.129 47.833  1    53.19  ? 414 LYS D CG  1 
ATOM   8673 C  CD  . LYS D 2 244 ? -53.904 -27.974 48.777  1    56.64  ? 414 LYS D CD  1 
ATOM   8674 C  CE  . LYS D 2 244 ? -53.535 -29.289 48.155  1    54.71  ? 414 LYS D CE  1 
ATOM   8675 N  NZ  . LYS D 2 244 ? -52.992 -30.188 49.17   1    54.51  ? 414 LYS D NZ  1 
ATOM   8676 N  N   . ASN D 2 245 ? -55.626 -22.76  48.513  1    51.8   ? 415 ASN D N   1 
ATOM   8677 C  CA  . ASN D 2 245 ? -55.988 -21.663 49.391  1    55.99  ? 415 ASN D CA  1 
ATOM   8678 C  C   . ASN D 2 245 ? -57.295 -21.031 48.904  1    54.74  ? 415 ASN D C   1 
ATOM   8679 O  O   . ASN D 2 245 ? -57.543 -20.967 47.698  1    56.63  ? 415 ASN D O   1 
ATOM   8680 C  CB  . ASN D 2 245 ? -54.802 -20.715 49.528  1    55.47  ? 415 ASN D CB  1 
ATOM   8681 C  CG  . ASN D 2 245 ? -54.994 -19.672 50.608  1    68.91  ? 415 ASN D CG  1 
ATOM   8682 O  OD1 . ASN D 2 245 ? -54.895 -18.462 50.336  1    78.97  ? 415 ASN D OD1 1 
ATOM   8683 N  ND2 . ASN D 2 245 ? -55.243 -20.111 51.836  1    73.51  ? 415 ASN D ND2 1 
ATOM   8684 N  N   . SER D 2 246 ? -58.116 -20.562 49.858  1    48.28  ? 416 SER D N   1 
ATOM   8685 C  CA  . SER D 2 246 ? -59.399 -19.947 49.56   1    48.03  ? 416 SER D CA  1 
ATOM   8686 C  C   . SER D 2 246 ? -59.234 -18.676 48.723  1    48.44  ? 416 SER D C   1 
ATOM   8687 O  O   . SER D 2 246 ? -60.157 -18.288 48.019  1    52.13  ? 416 SER D O   1 
ATOM   8688 C  CB  . SER D 2 246 ? -60.185 -19.669 50.81   1    45.42  ? 416 SER D CB  1 
ATOM   8689 O  OG  . SER D 2 246 ? -59.654 -18.544 51.495  1    49.67  ? 416 SER D OG  1 
ATOM   8690 N  N   . LYS D 2 247 ? -58.075 -18.017 48.819  1    44.34  ? 417 LYS D N   1 
ATOM   8691 C  CA  . LYS D 2 247 ? -57.785 -16.84  48.018  1    45.36  ? 417 LYS D CA  1 
ATOM   8692 C  C   . LYS D 2 247 ? -57.991 -17.118 46.529  1    50.15  ? 417 LYS D C   1 
ATOM   8693 O  O   . LYS D 2 247 ? -58.358 -16.206 45.787  1    47.78  ? 417 LYS D O   1 
ATOM   8694 C  CB  . LYS D 2 247 ? -56.316 -16.442 48.165  1    43.83  ? 417 LYS D CB  1 
ATOM   8695 C  CG  . LYS D 2 247 ? -55.943 -15.138 47.482  1    43.81  ? 417 LYS D CG  1 
ATOM   8696 C  CD  . LYS D 2 247 ? -54.451 -15.155 47.201  1    54.03  ? 417 LYS D CD  1 
ATOM   8697 C  CE  . LYS D 2 247 ? -53.614 -15.239 48.441  1    59.53  ? 417 LYS D CE  1 
ATOM   8698 N  NZ  . LYS D 2 247 ? -53.158 -13.906 48.848  1    62.34  ? 417 LYS D NZ  1 
ATOM   8699 N  N   . TYR D 2 248 ? -57.715 -18.366 46.1    1    52.58  ? 418 TYR D N   1 
ATOM   8700 C  CA  . TYR D 2 248 ? -57.853 -18.772 44.706  1    51.13  ? 418 TYR D CA  1 
ATOM   8701 C  C   . TYR D 2 248 ? -59.021 -19.744 44.547  1    49.74  ? 418 TYR D C   1 
ATOM   8702 O  O   . TYR D 2 248 ? -59.097 -20.449 43.538  1    49.11  ? 418 TYR D O   1 
ATOM   8703 C  CB  . TYR D 2 248 ? -56.54  -19.332 44.146  1    48.88  ? 418 TYR D CB  1 
ATOM   8704 C  CG  . TYR D 2 248 ? -55.356 -18.383 44.241  1    48.86  ? 418 TYR D CG  1 
ATOM   8705 C  CD1 . TYR D 2 248 ? -55.285 -17.259 43.419  1    50.04  ? 418 TYR D CD1 1 
ATOM   8706 C  CD2 . TYR D 2 248 ? -54.329 -18.589 45.164  1    45.27  ? 418 TYR D CD2 1 
ATOM   8707 C  CE1 . TYR D 2 248 ? -54.218 -16.375 43.506  1    45.72  ? 418 TYR D CE1 1 
ATOM   8708 C  CE2 . TYR D 2 248 ? -53.264 -17.708 45.261  1    44.95  ? 418 TYR D CE2 1 
ATOM   8709 C  CZ  . TYR D 2 248 ? -53.204 -16.6   44.423  1    46.47  ? 418 TYR D CZ  1 
ATOM   8710 O  OH  . TYR D 2 248 ? -52.171 -15.702 44.499  1    47.2   ? 418 TYR D OH  1 
ATOM   8711 N  N   . HIS D 2 249 ? -59.929 -19.768 45.536  1    48.88  ? 419 HIS D N   1 
ATOM   8712 C  CA  . HIS D 2 249 ? -61.201 -20.486 45.468  1    52.64  ? 419 HIS D CA  1 
ATOM   8713 C  C   . HIS D 2 249 ? -61.001 -21.998 45.321  1    49.03  ? 419 HIS D C   1 
ATOM   8714 O  O   . HIS D 2 249 ? -61.819 -22.661 44.678  1    48.57  ? 419 HIS D O   1 
ATOM   8715 C  CB  . HIS D 2 249 ? -62.089 -19.932 44.342  1    59.57  ? 419 HIS D CB  1 
ATOM   8716 C  CG  . HIS D 2 249 ? -62.238 -18.442 44.299  1    63.12  ? 419 HIS D CG  1 
ATOM   8717 N  ND1 . HIS D 2 249 ? -61.353 -17.63  43.626  1    60.66  ? 419 HIS D ND1 1 
ATOM   8718 C  CD2 . HIS D 2 249 ? -63.165 -17.617 44.819  1    64.76  ? 419 HIS D CD2 1 
ATOM   8719 C  CE1 . HIS D 2 249 ? -61.741 -16.364 43.743  1    62.86  ? 419 HIS D CE1 1 
ATOM   8720 N  NE2 . HIS D 2 249 ? -62.84  -16.333 44.462  1    57.21  ? 419 HIS D NE2 1 
ATOM   8721 N  N   . GLY D 2 250 ? -59.904 -22.52  45.899  1    47.67  ? 420 GLY D N   1 
ATOM   8722 C  CA  . GLY D 2 250 ? -59.586 -23.943 45.969  1    45.63  ? 420 GLY D CA  1 
ATOM   8723 C  C   . GLY D 2 250 ? -59.547 -24.674 44.621  1    46.16  ? 420 GLY D C   1 
ATOM   8724 O  O   . GLY D 2 250 ? -59.678 -25.898 44.598  1    44.35  ? 420 GLY D O   1 
ATOM   8725 N  N   . VAL D 2 251 ? -59.304 -23.942 43.522  1    42.73  ? 421 VAL D N   1 
ATOM   8726 C  CA  . VAL D 2 251 ? -59.471 -24.458 42.171  1    39.05  ? 421 VAL D CA  1 
ATOM   8727 C  C   . VAL D 2 251 ? -58.521 -25.626 41.883  1    40.49  ? 421 VAL D C   1 
ATOM   8728 O  O   . VAL D 2 251 ? -58.781 -26.42  40.981  1    46.56  ? 421 VAL D O   1 
ATOM   8729 C  CB  . VAL D 2 251 ? -59.359 -23.367 41.088  1    38.89  ? 421 VAL D CB  1 
ATOM   8730 C  CG1 . VAL D 2 251 ? -60.555 -22.425 41.122  1    36.46  ? 421 VAL D CG1 1 
ATOM   8731 C  CG2 . VAL D 2 251 ? -58.045 -22.586 41.172  1    39.06  ? 421 VAL D CG2 1 
ATOM   8732 N  N   . SER D 2 252 ? -57.423 -25.749 42.641  1    36.44  ? 422 SER D N   1 
ATOM   8733 C  CA  . SER D 2 252 ? -56.504 -26.861 42.428  1    33.86  ? 422 SER D CA  1 
ATOM   8734 C  C   . SER D 2 252 ? -57.14  -28.182 42.848  1    33.57  ? 422 SER D C   1 
ATOM   8735 O  O   . SER D 2 252 ? -56.761 -29.225 42.336  1    33.22  ? 422 SER D O   1 
ATOM   8736 C  CB  . SER D 2 252 ? -55.14  -26.654 43.058  1    34.06  ? 422 SER D CB  1 
ATOM   8737 O  OG  . SER D 2 252 ? -55.218 -26.419 44.453  1    37.96  ? 422 SER D OG  1 
ATOM   8738 N  N   . LEU D 2 253 ? -58.139 -28.123 43.733  1    33.65  ? 423 LEU D N   1 
ATOM   8739 C  CA  . LEU D 2 253 ? -58.808 -29.319 44.224  1    33.51  ? 423 LEU D CA  1 
ATOM   8740 C  C   . LEU D 2 253 ? -59.894 -29.811 43.267  1    32.54  ? 423 LEU D C   1 
ATOM   8741 O  O   . LEU D 2 253 ? -60.278 -30.968 43.35   1    32.71  ? 423 LEU D O   1 
ATOM   8742 C  CB  . LEU D 2 253 ? -59.344 -29.065 45.631  1    32.5   ? 423 LEU D CB  1 
ATOM   8743 C  CG  . LEU D 2 253 ? -58.281 -28.883 46.721  1    32.67  ? 423 LEU D CG  1 
ATOM   8744 C  CD1 . LEU D 2 253 ? -58.886 -28.316 47.993  1    29.4   ? 423 LEU D CD1 1 
ATOM   8745 C  CD2 . LEU D 2 253 ? -57.604 -30.215 47.013  1    32.3   ? 423 LEU D CD2 1 
ATOM   8746 N  N   . LEU D 2 254 ? -60.38  -28.958 42.356  1    33.78  ? 424 LEU D N   1 
ATOM   8747 C  CA  . LEU D 2 254 ? -61.381 -29.377 41.381  1    36.3   ? 424 LEU D CA  1 
ATOM   8748 C  C   . LEU D 2 254 ? -60.832 -30.504 40.517  1    39.71  ? 424 LEU D C   1 
ATOM   8749 O  O   . LEU D 2 254 ? -59.74  -30.371 39.98   1    49.51  ? 424 LEU D O   1 
ATOM   8750 C  CB  . LEU D 2 254 ? -61.783 -28.203 40.496  1    34.86  ? 424 LEU D CB  1 
ATOM   8751 C  CG  . LEU D 2 254 ? -62.567 -27.095 41.201  1    38.05  ? 424 LEU D CG  1 
ATOM   8752 C  CD1 . LEU D 2 254 ? -62.881 -25.944 40.24   1    36.38  ? 424 LEU D CD1 1 
ATOM   8753 C  CD2 . LEU D 2 254 ? -63.829 -27.713 41.823  1    34.44  ? 424 LEU D CD2 1 
ATOM   8754 N  N   . ASN D 2 255 ? -61.61  -31.583 40.359  1    40.66  ? 425 ASN D N   1 
ATOM   8755 C  CA  . ASN D 2 255 ? -61.241 -32.692 39.49   1    40.33  ? 425 ASN D CA  1 
ATOM   8756 C  C   . ASN D 2 255 ? -61.224 -32.195 38.045  1    40.11  ? 425 ASN D C   1 
ATOM   8757 O  O   . ASN D 2 255 ? -62.176 -31.547 37.619  1    40.96  ? 425 ASN D O   1 
ATOM   8758 C  CB  . ASN D 2 255 ? -62.173 -33.898 39.636  1    39.38  ? 425 ASN D CB  1 
ATOM   8759 C  CG  . ASN D 2 255 ? -62.126 -34.569 40.993  1    39.72  ? 425 ASN D CG  1 
ATOM   8760 O  OD1 . ASN D 2 255 ? -63.152 -35.074 41.472  1    39.39  ? 425 ASN D OD1 1 
ATOM   8761 N  ND2 . ASN D 2 255 ? -60.948 -34.645 41.601  1    38.95  ? 425 ASN D ND2 1 
ATOM   8762 N  N   . PRO D 2 256 ? -60.14  -32.445 37.264  1    39.31  ? 426 PRO D N   1 
ATOM   8763 C  CA  . PRO D 2 256 ? -60.116 -32.114 35.832  1    38.95  ? 426 PRO D CA  1 
ATOM   8764 C  C   . PRO D 2 256 ? -61.075 -32.943 34.98   1    41.57  ? 426 PRO D C   1 
ATOM   8765 O  O   . PRO D 2 256 ? -61.352 -34.09  35.317  1    44.05  ? 426 PRO D O   1 
ATOM   8766 C  CB  . PRO D 2 256 ? -58.655 -32.384 35.425  1    41.25  ? 426 PRO D CB  1 
ATOM   8767 C  CG  . PRO D 2 256 ? -58.121 -33.365 36.459  1    39.8   ? 426 PRO D CG  1 
ATOM   8768 C  CD  . PRO D 2 256 ? -58.875 -33.041 37.735  1    39.06  ? 426 PRO D CD  1 
ATOM   8769 N  N   . PRO D 2 257 ? -61.58  -32.439 33.829  1    40.19  ? 427 PRO D N   1 
ATOM   8770 C  CA  . PRO D 2 257 ? -62.435 -33.254 32.969  1    39.18  ? 427 PRO D CA  1 
ATOM   8771 C  C   . PRO D 2 257 ? -61.562 -34.391 32.443  1    43.66  ? 427 PRO D C   1 
ATOM   8772 O  O   . PRO D 2 257 ? -60.334 -34.266 32.427  1    43.48  ? 427 PRO D O   1 
ATOM   8773 C  CB  . PRO D 2 257 ? -62.904 -32.302 31.866  1    38.01  ? 427 PRO D CB  1 
ATOM   8774 C  CG  . PRO D 2 257 ? -61.842 -31.234 31.831  1    39.96  ? 427 PRO D CG  1 
ATOM   8775 C  CD  . PRO D 2 257 ? -61.307 -31.11  33.259  1    41.37  ? 427 PRO D CD  1 
ATOM   8776 N  N   . GLU D 2 258 ? -62.182 -35.513 32.087  1    47.2   ? 428 GLU D N   1 
ATOM   8777 C  CA  . GLU D 2 258 ? -61.368 -36.678 31.666  1    45.07  ? 428 GLU D CA  1 
ATOM   8778 C  C   . GLU D 2 258 ? -61.154 -36.565 30.159  1    44.1   ? 428 GLU D C   1 
ATOM   8779 O  O   . GLU D 2 258 ? -60.242 -37.232 29.635  1    39.41  ? 428 GLU D O   1 
ATOM   8780 C  CB  . GLU D 2 258 ? -62.055 -37.971 32.101  1    46.03  ? 428 GLU D CB  1 
ATOM   8781 C  CG  . GLU D 2 258 ? -62.675 -37.887 33.491  1    51.13  ? 428 GLU D CG  1 
ATOM   8782 C  CD  . GLU D 2 258 ? -63.592 -39.055 33.802  1    60.12  ? 428 GLU D CD  1 
ATOM   8783 O  OE1 . GLU D 2 258 ? -63.312 -40.17  33.317  1    61.28  ? 428 GLU D OE1 1 
ATOM   8784 O  OE2 . GLU D 2 258 ? -64.586 -38.85  34.527  1    69.07  ? 428 GLU D OE2 1 
ATOM   8785 N  N   . THR D 2 259 ? -61.956 -35.72  29.515  1    46.6   ? 429 THR D N   1 
ATOM   8786 C  CA  . THR D 2 259 ? -61.853 -35.549 28.057  1    49.1   ? 429 THR D CA  1 
ATOM   8787 C  C   . THR D 2 259 ? -62.514 -34.259 27.651  1    54.49  ? 429 THR D C   1 
ATOM   8788 O  O   . THR D 2 259 ? -63.274 -33.69  28.458  1    57.92  ? 429 THR D O   1 
ATOM   8789 C  CB  . THR D 2 259 ? -62.517 -36.732 27.357  1    48.5   ? 429 THR D CB  1 
ATOM   8790 O  OG1 . THR D 2 259 ? -62.66  -36.342 25.995  1    49.77  ? 429 THR D OG1 1 
ATOM   8791 C  CG2 . THR D 2 259 ? -63.882 -37.058 27.936  1    44.85  ? 429 THR D CG2 1 
ATOM   8792 N  N   . LEU D 2 260 ? -62.229 -33.815 26.432  1    60.57  ? 430 LEU D N   1 
ATOM   8793 C  CA  . LEU D 2 260 ? -62.843 -32.582 25.896  1    74.06  ? 430 LEU D CA  1 
ATOM   8794 C  C   . LEU D 2 260 ? -63.574 -32.958 24.604  1    92.38  ? 430 LEU D C   1 
ATOM   8795 O  O   . LEU D 2 260 ? -63.57  -34.152 24.243  1    98.67  ? 430 LEU D O   1 
ATOM   8796 C  CB  . LEU D 2 260 ? -61.733 -31.57  25.642  1    66.47  ? 430 LEU D CB  1 
ATOM   8797 C  CG  . LEU D 2 260 ? -60.984 -31.072 26.883  1    61.84  ? 430 LEU D CG  1 
ATOM   8798 C  CD1 . LEU D 2 260 ? -59.805 -30.183 26.531  1    52.59  ? 430 LEU D CD1 1 
ATOM   8799 C  CD2 . LEU D 2 260 ? -61.911 -30.368 27.855  1    60.81  ? 430 LEU D CD2 1 
ATOM   8800 N  N   . ASN D 2 261 ? -64.18  -31.975 23.945  1    103.51 ? 431 ASN D N   1 
ATOM   8801 C  CA  . ASN D 2 261 ? -64.93  -32.253 22.695  1    106.27 ? 431 ASN D CA  1 
ATOM   8802 C  C   . ASN D 2 261 ? -64.104 -31.74  21.514  1    107.56 ? 431 ASN D C   1 
ATOM   8803 O  O   . ASN D 2 261 ? -64.491 -30.716 20.918  1    109.77 ? 431 ASN D O   1 
ATOM   8804 C  CB  . ASN D 2 261 ? -66.327 -31.648 22.745  1    105.99 ? 431 ASN D CB  1 
ATOM   8805 C  CG  . ASN D 2 261 ? -67.227 -32.381 23.709  1    116.19 ? 431 ASN D CG  1 
ATOM   8806 O  OD1 . ASN D 2 261 ? -66.984 -33.553 24.018  1    130.85 ? 431 ASN D OD1 1 
ATOM   8807 N  ND2 . ASN D 2 261 ? -68.265 -31.715 24.191  1    108.47 ? 431 ASN D ND2 1 
ATOM   8808 N  N   . VAL D 2 262 ? -63.006 -32.425 21.201  1    102.64 ? 432 VAL D N   1 
ATOM   8809 C  CA  . VAL D 2 262 ? -62.108 -31.962 20.105  1    89.47  ? 432 VAL D CA  1 
ATOM   8810 C  C   . VAL D 2 262 ? -62.952 -31.57  18.887  1    72.84  ? 432 VAL D C   1 
ATOM   8811 O  O   . VAL D 2 262 ? -62.362 -31.493 17.792  1    62.84  ? 432 VAL D O   1 
ATOM   8812 C  CB  . VAL D 2 262 ? -61.103 -33.069 19.756  1    94.06  ? 432 VAL D CB  1 
ATOM   8813 C  CG1 . VAL D 2 262 ? -59.914 -33.065 20.707  1    87.8   ? 432 VAL D CG1 1 
ATOM   8814 C  CG2 . VAL D 2 262 ? -61.77  -34.439 19.739  1    95.57  ? 432 VAL D CG2 1 
HETATM 8815 C  C4  A IJF E 3 .   ? 13.843  -25.33  -8.207  0.5  58.4   ? 301 IJF A C4  1 
HETATM 8816 C  C4  B IJF E 3 .   ? 14.109  -25.809 -8.067  0.5  47.37  ? 301 IJF A C4  1 
HETATM 8817 C  C5  A IJF E 3 .   ? 12.984  -24.25  -8.333  0.5  58.49  ? 301 IJF A C5  1 
HETATM 8818 C  C5  B IJF E 3 .   ? 14.981  -26.404 -7.167  0.5  43.95  ? 301 IJF A C5  1 
HETATM 8819 C  C6  A IJF E 3 .   ? 13.017  -23.301 -7.341  0.5  60.71  ? 301 IJF A C6  1 
HETATM 8820 C  C6  B IJF E 3 .   ? 15.273  -25.71  -6.014  0.5  44.23  ? 301 IJF A C6  1 
HETATM 8821 N  N1  A IJF E 3 .   ? 13.828  -23.371 -6.27   0.5  62.48  ? 301 IJF A N1  1 
HETATM 8822 N  N1  B IJF E 3 .   ? 14.754  -24.503 -5.73   0.5  50.22  ? 301 IJF A N1  1 
HETATM 8823 C  C3  A IJF E 3 .   ? 14.696  -25.424 -7.112  0.5  52.97  ? 301 IJF A C3  1 
HETATM 8824 C  C3  B IJF E 3 .   ? 13.555  -24.571 -7.789  0.5  47.98  ? 301 IJF A C3  1 
HETATM 8825 O  O1  A IJF E 3 .   ? 15.284  -23.227 -4.081  0.5  35     ? 301 IJF A O1  1 
HETATM 8826 O  O1  B IJF E 3 .   ? 12.196  -22.17  -6.901  0.5  38.11  ? 301 IJF A O1  1 
HETATM 8827 C  C1  A IJF E 3 .   ? 15.554  -24.348 -4.922  0.5  44.13  ? 301 IJF A C1  1 
HETATM 8828 C  C1  B IJF E 3 .   ? 13.346  -22.583 -6.188  0.5  44.1   ? 301 IJF A C1  1 
HETATM 8829 C  C2  A IJF E 3 .   ? 14.67   -24.414 -6.151  0.5  54.5   ? 301 IJF A C2  1 
HETATM 8830 C  C2  B IJF E 3 .   ? 13.894  -23.935 -6.6    0.5  49.36  ? 301 IJF A C2  1 
HETATM 8831 BR BR1 A IJF E 3 .   ? 13.804  -26.667 -9.554  0.5  74.54  ? 301 IJF A BR1 1 
HETATM 8832 BR BR1 B IJF E 3 .   ? 13.67   -26.711 -9.679  0.5  64.27  ? 301 IJF A BR1 1 
HETATM 8833 C  C4  A IJF F 3 .   ? -8.937  -21.526 23.438  0.5  75.45  ? 302 IJF A C4  1 
HETATM 8834 C  C4  B IJF F 3 .   ? -8.284  -21.616 23.548  0.5  72.74  ? 302 IJF A C4  1 
HETATM 8835 C  C5  A IJF F 3 .   ? -10.107 -21.01  22.9    0.5  58.93  ? 302 IJF A C5  1 
HETATM 8836 C  C5  B IJF F 3 .   ? -6.908  -21.404 23.499  0.5  61.92  ? 302 IJF A C5  1 
HETATM 8837 C  C6  A IJF F 3 .   ? -9.974  -20.015 21.954  0.5  53.55  ? 302 IJF A C6  1 
HETATM 8838 C  C6  B IJF F 3 .   ? -6.46   -20.465 22.585  0.5  66.22  ? 302 IJF A C6  1 
HETATM 8839 N  N1  A IJF F 3 .   ? -8.79   -19.548 21.523  0.5  60.33  ? 302 IJF A N1  1 
HETATM 8840 N  N1  B IJF F 3 .   ? -7.284  -19.801 21.739  0.5  69.1   ? 302 IJF A N1  1 
HETATM 8841 C  C3  A IJF F 3 .   ? -7.705  -21.057 23.016  0.5  78.45  ? 302 IJF A C3  1 
HETATM 8842 C  C3  B IJF F 3 .   ? -9.143  -20.923 22.703  0.5  63.74  ? 302 IJF A C3  1 
HETATM 8843 O  O1  A IJF F 3 .   ? -5.274  -20.425 21.896  0.5  62.15  ? 302 IJF A O1  1 
HETATM 8844 O  O1  B IJF F 3 .   ? -9.039  -19.321 19.521  0.5  36.59  ? 302 IJF A O1  1 
HETATM 8845 C  C1  A IJF F 3 .   ? -6.337  -19.54  21.556  0.5  76.13  ? 302 IJF A C1  1 
HETATM 8846 C  C1  B IJF F 3 .   ? -9.479  -19.209 20.859  0.5  49.82  ? 302 IJF A C1  1 
HETATM 8847 C  C2  A IJF F 3 .   ? -7.663  -20.073 22.041  0.5  73.67  ? 302 IJF A C2  1 
HETATM 8848 C  C2  B IJF F 3 .   ? -8.614  -20.008 21.805  0.5  56.87  ? 302 IJF A C2  1 
HETATM 8849 BR BR1 A IJF F 3 .   ? -9.025  -22.882 24.759  0.5  71.56  ? 302 IJF A BR1 1 
HETATM 8850 BR BR1 B IJF F 3 .   ? -8.999  -22.876 24.773  0.5  69.15  ? 302 IJF A BR1 1 
HETATM 8851 C  C4  . IJF G 3 .   ? -19.29  -10.07  20.391  1    53.72  ? 303 IJF A C4  1 
HETATM 8852 C  C5  . IJF G 3 .   ? -18.606 -9.416  19.36   1    47.04  ? 303 IJF A C5  1 
HETATM 8853 C  C6  . IJF G 3 .   ? -18.547 -8.023  19.381  1    39.32  ? 303 IJF A C6  1 
HETATM 8854 N  N1  . IJF G 3 .   ? -19.127 -7.284  20.343  1    46.97  ? 303 IJF A N1  1 
HETATM 8855 C  C3  . IJF G 3 .   ? -19.891 -9.317  21.385  1    48.63  ? 303 IJF A C3  1 
HETATM 8856 O  O1  . IJF G 3 .   ? -20.954 -7.921  23.408  1    64.79  ? 303 IJF A O1  1 
HETATM 8857 C  C1  . IJF G 3 .   ? -20.42  -7.079  22.407  1    57.43  ? 303 IJF A C1  1 
HETATM 8858 C  C2  . IJF G 3 .   ? -19.791 -7.928  21.332  1    56.74  ? 303 IJF A C2  1 
HETATM 8859 BR BR1 . IJF G 3 .   ? -19.402 -11.981 20.444  1    58.14  ? 303 IJF A BR1 1 
HETATM 8860 C  C4  . IJF H 3 .   ? -7.802  -11.368 32.946  1    90.72  ? 304 IJF A C4  1 
HETATM 8861 C  C5  . IJF H 3 .   ? -8.753  -12.149 33.594  1    77.88  ? 304 IJF A C5  1 
HETATM 8862 C  C6  . IJF H 3 .   ? -9.578  -11.531 34.53   1    72.65  ? 304 IJF A C6  1 
HETATM 8863 N  N1  . IJF H 3 .   ? -9.459  -10.23  34.856  1    71.17  ? 304 IJF A N1  1 
HETATM 8864 C  C3  . IJF H 3 .   ? -7.67   -10.023 33.269  1    76.88  ? 304 IJF A C3  1 
HETATM 8865 O  O1  . IJF H 3 .   ? -9.21   -7.827  35.847  1    58.35  ? 304 IJF A O1  1 
HETATM 8866 C  C1  . IJF H 3 .   ? -8.473  -8.038  34.654  1    62     ? 304 IJF A C1  1 
HETATM 8867 C  C2  . IJF H 3 .   ? -8.52   -9.484  34.233  1    71.68  ? 304 IJF A C2  1 
HETATM 8868 BR BR1 . IJF H 3 .   ? -6.686  -12.153 31.62   1    142.27 ? 304 IJF A BR1 1 
HETATM 8869 C  C4  . IJF I 3 .   ? -27.354 1.88    -0.626  1    56.77  ? 701 IJF B C4  1 
HETATM 8870 C  C5  . IJF I 3 .   ? -28.483 1.069   -0.71   1    42.87  ? 701 IJF B C5  1 
HETATM 8871 C  C6  . IJF I 3 .   ? -28.599 0.056   0.215   1    48.17  ? 701 IJF B C6  1 
HETATM 8872 N  N1  . IJF I 3 .   ? -27.684 -0.172  1.179   1    67.34  ? 701 IJF B N1  1 
HETATM 8873 C  C3  . IJF I 3 .   ? -26.41  1.672   0.362   1    53.64  ? 701 IJF B C3  1 
HETATM 8874 O  O1  . IJF I 3 .   ? -24.549 1.33    2.248   1    47.28  ? 701 IJF B O1  1 
HETATM 8875 C  C1  . IJF I 3 .   ? -25.574 0.362   2.332   1    48.05  ? 701 IJF B C1  1 
HETATM 8876 C  C2  . IJF I 3 .   ? -26.589 0.619   1.245   1    63.4   ? 701 IJF B C2  1 
HETATM 8877 BR BR1 . IJF I 3 .   ? -27.113 3.328   -1.839  1    67.46  ? 701 IJF B BR1 1 
HETATM 8878 C  C4  A IJF J 3 .   ? -18.934 17.96   3.907   0.5  83.38  ? 702 IJF B C4  1 
HETATM 8879 C  C4  B IJF J 3 .   ? -19.009 18.119  4.014   0.5  93.11  ? 702 IJF B C4  1 
HETATM 8880 C  C5  A IJF J 3 .   ? -17.994 18.497  4.776   0.5  78.55  ? 702 IJF B C5  1 
HETATM 8881 C  C5  B IJF J 3 .   ? -20.075 18.958  3.732   0.5  93.86  ? 702 IJF B C5  1 
HETATM 8882 C  C6  A IJF J 3 .   ? -18.16  19.806  5.16    0.5  73.31  ? 702 IJF B C6  1 
HETATM 8883 C  C6  B IJF J 3 .   ? -20.094 20.183  4.359   0.5  89.31  ? 702 IJF B C6  1 
HETATM 8884 N  N1  A IJF J 3 .   ? -19.166 20.583  4.714   0.5  73.12  ? 702 IJF B N1  1 
HETATM 8885 N  N1  B IJF J 3 .   ? -19.125 20.601  5.2     0.5  79.24  ? 702 IJF B N1  1 
HETATM 8886 C  C3  A IJF J 3 .   ? -19.977 18.74   3.445   0.5  76.92  ? 702 IJF B C3  1 
HETATM 8887 C  C3  B IJF J 3 .   ? -18.006 18.529  4.871   0.5  80.85  ? 702 IJF B C3  1 
HETATM 8888 O  O1  A IJF J 3 .   ? -21.483 20.946  2.07    0.5  39.54  ? 702 IJF B O1  1 
HETATM 8889 O  O1  B IJF J 3 .   ? -17.659 21.141  7.407   0.5  46.13  ? 702 IJF B O1  1 
HETATM 8890 C  C1  A IJF J 3 .   ? -21.186 20.985  3.442   0.5  54.01  ? 702 IJF B C1  1 
HETATM 8891 C  C1  B IJF J 3 .   ? -17.059 20.291  6.44    0.5  57.05  ? 702 IJF B C1  1 
HETATM 8892 C  C2  A IJF J 3 .   ? -20.071 20.059  3.867   0.5  67.29  ? 702 IJF B C2  1 
HETATM 8893 C  C2  B IJF J 3 .   ? -18.09  19.781  5.462   0.5  70.49  ? 702 IJF B C2  1 
HETATM 8894 BR BR1 A IJF J 3 .   ? -18.784 16.15   3.357   0.5  98.84  ? 702 IJF B BR1 1 
HETATM 8895 BR BR1 B IJF J 3 .   ? -18.939 16.402  3.214   0.5  111.11 ? 702 IJF B BR1 1 
HETATM 8896 C  C4  . IJF K 3 .   ? -14.323 16.176  1.816   1    83.55  ? 703 IJF B C4  1 
HETATM 8897 C  C5  . IJF K 3 .   ? -14.755 17.493  1.675   1    79.52  ? 703 IJF B C5  1 
HETATM 8898 C  C6  . IJF K 3 .   ? -13.857 18.393  1.141   1    87.21  ? 703 IJF B C6  1 
HETATM 8899 N  N1  . IJF K 3 .   ? -12.605 18.045  0.764   1    107.23 ? 703 IJF B N1  1 
HETATM 8900 C  C3  . IJF K 3 .   ? -13.046 15.791  1.416   1    101.26 ? 703 IJF B C3  1 
HETATM 8901 O  O1  . IJF K 3 .   ? -9.848  16.391  1.533   1    89.11  ? 703 IJF B O1  1 
HETATM 8902 C  C1  . IJF K 3 .   ? -10.774 16.481  0.462   1    94.05  ? 703 IJF B C1  1 
HETATM 8903 C  C2  . IJF K 3 .   ? -12.193 16.767  0.905   1    107.19 ? 703 IJF B C2  1 
HETATM 8904 BR BR1 . IJF K 3 .   ? -15.503 14.891  2.561   1    83.41  ? 703 IJF B BR1 1 
HETATM 8905 C  C4  A IJF L 3 .   ? -29.538 1.506   25.268  0.5  64.86  ? 301 IJF C C4  1 
HETATM 8906 C  C4  B IJF L 3 .   ? -29.779 1.501   25.482  0.5  71.03  ? 301 IJF C C4  1 
HETATM 8907 C  C5  A IJF L 3 .   ? -28.275 1.432   24.693  0.5  61.71  ? 301 IJF C C5  1 
HETATM 8908 C  C5  B IJF L 3 .   ? -30.346 0.869   26.587  0.5  62     ? 301 IJF C C5  1 
HETATM 8909 C  C6  A IJF L 3 .   ? -27.4   0.485   25.203  0.5  65.87  ? 301 IJF C C6  1 
HETATM 8910 C  C6  B IJF L 3 .   ? -29.63  -0.154  27.177  0.5  58.88  ? 301 IJF C C6  1 
HETATM 8911 N  N1  A IJF L 3 .   ? -27.714 -0.351  26.211  0.5  62.01  ? 301 IJF C N1  1 
HETATM 8912 N  N1  B IJF L 3 .   ? -28.433 -0.573  26.727  0.5  63.44  ? 301 IJF C N1  1 
HETATM 8913 C  C3  A IJF L 3 .   ? -29.88  0.645   26.312  0.5  58.35  ? 301 IJF C C3  1 
HETATM 8914 C  C3  B IJF L 3 .   ? -28.541 1.084   25.01   0.5  68.52  ? 301 IJF C C3  1 
HETATM 8915 O  O1  A IJF L 3 .   ? -28.029 -1.962  28.326  0.5  32.8   ? 301 IJF C O1  1 
HETATM 8916 O  O1  B IJF L 3 .   ? -25.597 0.466   24.78   0.5  51.32  ? 301 IJF C O1  1 
HETATM 8917 C  C1  A IJF L 3 .   ? -29.182 -1.266  27.877  0.5  44.71  ? 301 IJF C C1  1 
HETATM 8918 C  C1  B IJF L 3 .   ? -26.535 -0.496  25.227  0.5  61.38  ? 301 IJF C C1  1 
HETATM 8919 C  C2  A IJF L 3 .   ? -28.939 -0.279  26.762  0.5  53.66  ? 301 IJF C C2  1 
HETATM 8920 C  C2  B IJF L 3 .   ? -27.882 0.044   25.662  0.5  67.74  ? 301 IJF C C2  1 
HETATM 8921 BR BR1 A IJF L 3 .   ? -30.788 2.779   24.599  0.5  66.21  ? 301 IJF C BR1 1 
HETATM 8922 BR BR1 B IJF L 3 .   ? -30.717 2.917   24.614  0.5  69.88  ? 301 IJF C BR1 1 
HETATM 8923 C  C4  A IJF M 3 .   ? -32.641 16.166  29.027  0.08 11.5   ? 302 IJF C C4  1 
HETATM 8924 C  C4  B IJF M 3 .   ? -32.568 16.619  29.446  0.08 13.28  ? 302 IJF C C4  1 
HETATM 8925 C  C4  C IJF M 3 .   ? -33.928 13.968  30.491  0.33 73.91  ? 302 IJF C C4  1 
HETATM 8926 C  C4  D IJF M 3 .   ? -33.922 13.969  30.496  0.5  114.25 ? 302 IJF C C4  1 
HETATM 8927 C  C5  A IJF M 3 .   ? -32.958 15.01   28.351  0.08 11.66  ? 302 IJF C C5  1 
HETATM 8928 C  C5  B IJF M 3 .   ? -32.373 17.066  30.744  0.08 13.42  ? 302 IJF C C5  1 
HETATM 8929 C  C5  C IJF M 3 .   ? -34.184 14.302  31.813  0.33 71.43  ? 302 IJF C C5  1 
HETATM 8930 C  C5  D IJF M 3 .   ? -34.534 12.787  30.079  0.5  105.45 ? 302 IJF C C5  1 
HETATM 8931 C  C6  A IJF M 3 .   ? -33.311 13.924  29.118  0.08 11.85  ? 302 IJF C C6  1 
HETATM 8932 C  C6  B IJF M 3 .   ? -32.732 16.201  31.759  0.08 13.65  ? 302 IJF C C6  1 
HETATM 8933 C  C6  C IJF M 3 .   ? -35.059 13.494  32.512  0.33 64.22  ? 302 IJF C C6  1 
HETATM 8934 C  C6  D IJF M 3 .   ? -35.338 12.124  30.991  0.5  94.81  ? 302 IJF C C6  1 
HETATM 8935 N  N1  A IJF M 3 .   ? -33.345 13.943  30.461  0.08 11.67  ? 302 IJF C N1  1 
HETATM 8936 N  N1  B IJF M 3 .   ? -33.238 14.975  31.537  0.08 13.7   ? 302 IJF C N1  1 
HETATM 8937 N  N1  C IJF M 3 .   ? -35.658 12.413  31.98   0.33 58.06  ? 302 IJF C N1  1 
HETATM 8938 N  N1  D IJF M 3 .   ? -35.561 12.584  32.237  0.5  92.98  ? 302 IJF C N1  1 
HETATM 8939 C  C3  A IJF M 3 .   ? -32.68  16.228  30.403  0.08 11.6   ? 302 IJF C C3  1 
HETATM 8940 C  C3  B IJF M 3 .   ? -33.08  15.372  29.198  0.08 13.66  ? 302 IJF C C3  1 
HETATM 8941 C  C3  C IJF M 3 .   ? -34.561 12.864  29.917  0.33 62.44  ? 302 IJF C C3  1 
HETATM 8942 C  C3  D IJF M 3 .   ? -34.152 14.454  31.772  0.5  102.73 ? 302 IJF C C3  1 
HETATM 8943 O  O1  A IJF M 3 .   ? -33.555 16.251  33.168  0.08 11.57  ? 302 IJF C O1  1 
HETATM 8944 O  O1  B IJF M 3 .   ? -35.028 12.875  30.924  0.08 14.61  ? 302 IJF C O1  1 
HETATM 8945 O  O1  C IJF M 3 .   ? -36.776 10.082  31.181  0.33 31.88  ? 302 IJF C O1  1 
HETATM 8946 O  O1  D IJF M 3 .   ? -34.138 14.206  34.841  0.5  66.65  ? 302 IJF C O1  1 
HETATM 8947 C  C1  A IJF M 3 .   ? -33.135 15.028  32.604  0.08 11.75  ? 302 IJF C C1  1 
HETATM 8948 C  C1  B IJF M 3 .   ? -33.974 13.185  30.053  0.08 14.25  ? 302 IJF C C1  1 
HETATM 8949 C  C1  C IJF M 3 .   ? -36.159 10.877  30.191  0.33 40.57  ? 302 IJF C C1  1 
HETATM 8950 C  C1  D IJF M 3 .   ? -35.282 14.188  34.027  0.5  73.4   ? 302 IJF C C1  1 
HETATM 8951 C  C2  A IJF M 3 .   ? -33.051 15.087  31.1    0.08 11.66  ? 302 IJF C C2  1 
HETATM 8952 C  C2  B IJF M 3 .   ? -33.414 14.566  30.27   0.08 13.83  ? 302 IJF C C2  1 
HETATM 8953 C  C2  C IJF M 3 .   ? -35.42  12.093  30.697  0.33 51.39  ? 302 IJF C C2  1 
HETATM 8954 C  C2  D IJF M 3 .   ? -34.985 13.736  32.621  0.5  89.94  ? 302 IJF C C2  1 
HETATM 8955 BR BR1 A IJF M 3 .   ? -32.16  17.665  28.001  0.08 10.85  ? 302 IJF C BR1 1 
HETATM 8956 BR BR1 B IJF M 3 .   ? -32.137 17.714  27.972  0.08 12.37  ? 302 IJF C BR1 1 
HETATM 8957 BR BR1 C IJF M 3 .   ? -32.743 15.075  29.499  0.33 100.02 ? 302 IJF C BR1 1 
HETATM 8958 BR BR1 D IJF M 3 .   ? -32.802 14.953  29.314  0.5  136.56 ? 302 IJF C BR1 1 
HETATM 8959 C  C4  . IJF N 3 .   ? -19.27  13.058  32.548  1    87.56  ? 303 IJF C C4  1 
HETATM 8960 C  C5  . IJF N 3 .   ? -19.124 13.701  31.325  1    71.02  ? 303 IJF C C5  1 
HETATM 8961 C  C6  . IJF N 3 .   ? -18.026 13.36   30.558  1    73.6   ? 303 IJF C C6  1 
HETATM 8962 N  N1  . IJF N 3 .   ? -17.109 12.452  30.946  1    73.7   ? 303 IJF C N1  1 
HETATM 8963 C  C3  . IJF N 3 .   ? -18.351 12.109  32.965  1    77.47  ? 303 IJF C C3  1 
HETATM 8964 O  O1  . IJF N 3 .   ? -15.227 10.736  31.505  1    60.1   ? 303 IJF C O1  1 
HETATM 8965 C  C1  . IJF N 3 .   ? -16.213 10.822  32.508  1    63.12  ? 303 IJF C C1  1 
HETATM 8966 C  C2  . IJF N 3 .   ? -17.274 11.825  32.132  1    76.82  ? 303 IJF C C2  1 
HETATM 8967 BR BR1 . IJF N 3 .   ? -20.758 13.467  33.647  1    124.56 ? 303 IJF C BR1 1 
HETATM 8968 C  C4  A IJF O 3 .   ? -40.823 42.933  28.033  0.5  36.54  ? 304 IJF C C4  1 
HETATM 8969 C  C4  B IJF O 3 .   ? -41.062 43.169  28.355  0.5  44.7   ? 304 IJF C C4  1 
HETATM 8970 C  C5  A IJF O 3 .   ? -39.736 42.829  27.177  0.5  37.72  ? 304 IJF C C5  1 
HETATM 8971 C  C5  B IJF O 3 .   ? -42.154 42.348  28.118  0.5  48.12  ? 304 IJF C C5  1 
HETATM 8972 C  C6  A IJF O 3 .   ? -40.008 42.674  25.834  0.5  39.37  ? 304 IJF C C6  1 
HETATM 8973 C  C6  B IJF O 3 .   ? -42.297 41.843  26.844  0.5  50.9   ? 304 IJF C C6  1 
HETATM 8974 N  N1  A IJF O 3 .   ? -41.258 42.617  25.334  0.5  41.4   ? 304 IJF C N1  1 
HETATM 8975 N  N1  B IJF O 3 .   ? -41.433 42.101  25.844  0.5  53.18  ? 304 IJF C N1  1 
HETATM 8976 C  C3  A IJF O 3 .   ? -42.113 42.869  27.539  0.5  38.1   ? 304 IJF C C3  1 
HETATM 8977 C  C3  B IJF O 3 .   ? -40.168 43.451  27.34   0.5  48.02  ? 304 IJF C C3  1 
HETATM 8978 O  O1  A IJF O 3 .   ? -44.083 43.843  24.919  0.5  34.28  ? 304 IJF C O1  1 
HETATM 8979 O  O1  B IJF O 3 .   ? -38.568 42.104  24.651  0.5  46.3   ? 304 IJF C O1  1 
HETATM 8980 C  C1  A IJF O 3 .   ? -43.681 42.641  25.549  0.5  36.6   ? 304 IJF C C1  1 
HETATM 8981 C  C1  B IJF O 3 .   ? -39.453 43.166  24.92   0.5  46.67  ? 304 IJF C C1  1 
HETATM 8982 C  C2  A IJF O 3 .   ? -42.306 42.716  26.173  0.5  38.9   ? 304 IJF C C2  1 
HETATM 8983 C  C2  B IJF O 3 .   ? -40.377 42.899  26.084  0.5  49.37  ? 304 IJF C C2  1 
HETATM 8984 BR BR1 A IJF O 3 .   ? -40.535 43.167  29.89   0.5  32.22  ? 304 IJF C BR1 1 
HETATM 8985 BR BR1 B IJF O 3 .   ? -40.808 43.92   30.076  0.5  35.34  ? 304 IJF C BR1 1 
HETATM 8986 C  C4  . IJF P 3 .   ? -42.896 -20.723 29.042  1    67.94  ? 501 IJF D C4  1 
HETATM 8987 C  C5  . IJF P 3 .   ? -43.341 -20.747 27.723  1    60.21  ? 501 IJF D C5  1 
HETATM 8988 C  C6  . IJF P 3 .   ? -43.021 -19.672 26.914  1    54.37  ? 501 IJF D C6  1 
HETATM 8989 N  N1  . IJF P 3 .   ? -42.306 -18.618 27.341  1    63.71  ? 501 IJF D N1  1 
HETATM 8990 C  C3  . IJF P 3 .   ? -42.165 -19.641 29.495  1    65.9   ? 501 IJF D C3  1 
HETATM 8991 O  O1  . IJF P 3 .   ? -40.549 -17.613 30.334  1    65.31  ? 501 IJF D O1  1 
HETATM 8992 C  C1  . IJF P 3 .   ? -41.098 -17.397 29.055  1    61.37  ? 501 IJF D C1  1 
HETATM 8993 C  C2  . IJF P 3 .   ? -41.884 -18.603 28.618  1    65.51  ? 501 IJF D C2  1 
HETATM 8994 BR BR1 . IJF P 3 .   ? -43.27  -22.162 30.233  1    63.01  ? 501 IJF D BR1 1 
HETATM 8995 O  O   . HOH Q 4 .   ? -12.939 -28.697 -5.056  1    27.64  ? 401 HOH A O   1 
HETATM 8996 O  O   . HOH Q 4 .   ? 4.536   -19.723 -5.261  1    39.29  ? 402 HOH A O   1 
HETATM 8997 O  O   . HOH Q 4 .   ? 0.725   -15.733 3.771   1    33.38  ? 403 HOH A O   1 
HETATM 8998 O  O   . HOH Q 4 .   ? -15.735 -37.937 19.245  1    36.73  ? 404 HOH A O   1 
HETATM 8999 O  O   . HOH Q 4 .   ? -19.681 -15.194 42.803  1    29.57  ? 405 HOH A O   1 
HETATM 9000 O  O   . HOH Q 4 .   ? -13.535 -11.729 -3.098  1    28.11  ? 406 HOH A O   1 
HETATM 9001 O  O   . HOH Q 4 .   ? 1.97    -54.217 -0.772  1    28.42  ? 407 HOH A O   1 
HETATM 9002 O  O   . HOH Q 4 .   ? -23.193 -8.127  19.473  1    62.51  ? 408 HOH A O   1 
HETATM 9003 O  O   . HOH Q 4 .   ? 7.693   -20.002 -13.331 1    42.69  ? 409 HOH A O   1 
HETATM 9004 O  O   . HOH Q 4 .   ? -21.798 -17.713 31.64   1    16.32  ? 410 HOH A O   1 
HETATM 9005 O  O   . HOH Q 4 .   ? -11.587 -16.576 -9.249  1    42     ? 411 HOH A O   1 
HETATM 9006 O  O   . HOH Q 4 .   ? -4.94   -38.195 -4.312  1    37.45  ? 412 HOH A O   1 
HETATM 9007 O  O   . HOH Q 4 .   ? -14.17  -36.044 -4.701  1    49.99  ? 413 HOH A O   1 
HETATM 9008 O  O   . HOH Q 4 .   ? -16.758 -26.124 25.312  1    50.8   ? 414 HOH A O   1 
HETATM 9009 O  O   . HOH Q 4 .   ? -18.881 -38.006 15.67   1    45.06  ? 415 HOH A O   1 
HETATM 9010 O  O   . HOH Q 4 .   ? -15.352 -11.889 -5.184  1    29.64  ? 416 HOH A O   1 
HETATM 9011 O  O   . HOH Q 4 .   ? 15.237  -31.511 -14.049 1    21.97  ? 417 HOH A O   1 
HETATM 9012 O  O   . HOH Q 4 .   ? -23.074 -15.535 17.853  1    49.19  ? 418 HOH A O   1 
HETATM 9013 O  O   . HOH Q 4 .   ? -6.996  -13.081 8.324   1    36.62  ? 419 HOH A O   1 
HETATM 9014 O  O   . HOH Q 4 .   ? -4.532  -9.17   7.666   1    40.4   ? 420 HOH A O   1 
HETATM 9015 O  O   . HOH Q 4 .   ? 3.787   -20.948 -0.972  1    28.9   ? 421 HOH A O   1 
HETATM 9016 O  O   . HOH Q 4 .   ? -12.649 -10.32  2.785   1    24.61  ? 422 HOH A O   1 
HETATM 9017 O  O   . HOH Q 4 .   ? -3.253  -13.046 6.199   1    38.71  ? 423 HOH A O   1 
HETATM 9018 O  O   . HOH Q 4 .   ? -19.264 -31.432 23.43   1    28.67  ? 424 HOH A O   1 
HETATM 9019 O  O   . HOH Q 4 .   ? -8.022  -16.572 -4.162  1    29.26  ? 425 HOH A O   1 
HETATM 9020 O  O   . HOH Q 4 .   ? -1.403  -17.76  -3.583  1    32.95  ? 426 HOH A O   1 
HETATM 9021 O  O   . HOH Q 4 .   ? -12.546 -34.52  22.156  1    36.21  ? 427 HOH A O   1 
HETATM 9022 O  O   . HOH Q 4 .   ? -14.444 -27.036 -1.36   1    28.02  ? 428 HOH A O   1 
HETATM 9023 O  O   . HOH Q 4 .   ? 2.217   -29.524 13.065  1    39.14  ? 429 HOH A O   1 
HETATM 9024 O  O   . HOH Q 4 .   ? 0.212   -33.589 8.311   1    32.53  ? 430 HOH A O   1 
HETATM 9025 O  O   . HOH Q 4 .   ? -19.533 -21.419 17.007  1    40.71  ? 431 HOH A O   1 
HETATM 9026 O  O   . HOH Q 4 .   ? -3.301  -21.021 17.709  1    42.79  ? 432 HOH A O   1 
HETATM 9027 O  O   . HOH Q 4 .   ? -20.266 -21.752 26.238  1    40.99  ? 433 HOH A O   1 
HETATM 9028 O  O   . HOH Q 4 .   ? -7.991  -23.836 -4.236  1    26.69  ? 434 HOH A O   1 
HETATM 9029 O  O   . HOH Q 4 .   ? -9.434  -52.129 3.143   1    37.07  ? 435 HOH A O   1 
HETATM 9030 O  O   . HOH Q 4 .   ? 5.313   -42.145 1.184   1    32.17  ? 436 HOH A O   1 
HETATM 9031 O  O   . HOH Q 4 .   ? -17.034 -22.367 27.986  1    44.56  ? 437 HOH A O   1 
HETATM 9032 O  O   . HOH Q 4 .   ? -19.013 -24.448 19.47   1    26.39  ? 438 HOH A O   1 
HETATM 9033 O  O   . HOH Q 4 .   ? -26.918 -19.98  8.394   1    39.18  ? 439 HOH A O   1 
HETATM 9034 O  O   . HOH Q 4 .   ? -23.493 -42.607 15.793  1    28.25  ? 440 HOH A O   1 
HETATM 9035 O  O   . HOH Q 4 .   ? -3.787  -25.508 2.177   1    37.24  ? 441 HOH A O   1 
HETATM 9036 O  O   . HOH Q 4 .   ? -21.776 -28.684 8.02    1    28.56  ? 442 HOH A O   1 
HETATM 9037 O  O   . HOH Q 4 .   ? -2.875  -19.997 -5.389  1    28.46  ? 443 HOH A O   1 
HETATM 9038 O  O   . HOH Q 4 .   ? -6.161  -24.481 6.162   1    35.1   ? 444 HOH A O   1 
HETATM 9039 O  O   . HOH Q 4 .   ? -6.627  -12.199 16.147  1    35.85  ? 445 HOH A O   1 
HETATM 9040 O  O   . HOH Q 4 .   ? 4.444   -21.913 7.66    1    28.12  ? 446 HOH A O   1 
HETATM 9041 O  O   . HOH Q 4 .   ? 1.796   -32.498 6.368   1    27.7   ? 447 HOH A O   1 
HETATM 9042 O  O   . HOH Q 4 .   ? -1.189  -24.99  -18.855 1    40.92  ? 448 HOH A O   1 
HETATM 9043 O  O   . HOH Q 4 .   ? -2.735  -18.101 7.131   1    44.95  ? 449 HOH A O   1 
HETATM 9044 O  O   . HOH Q 4 .   ? -2.7    -15.56  -3.647  1    24.6   ? 450 HOH A O   1 
HETATM 9045 O  O   . HOH Q 4 .   ? -21.968 -18.823 27.64   1    33.93  ? 451 HOH A O   1 
HETATM 9046 O  O   . HOH Q 4 .   ? -7.631  -18.555 10.548  1    25.68  ? 452 HOH A O   1 
HETATM 9047 O  O   . HOH Q 4 .   ? 11.471  -39.143 -14.052 1    27.29  ? 453 HOH A O   1 
HETATM 9048 O  O   . HOH Q 4 .   ? -5.313  -15.911 -4.49   1    30.87  ? 454 HOH A O   1 
HETATM 9049 O  O   . HOH Q 4 .   ? 1.1     -29.614 2.389   1    29.87  ? 455 HOH A O   1 
HETATM 9050 O  O   . HOH Q 4 .   ? -18.794 -16.223 30.787  1    33.53  ? 456 HOH A O   1 
HETATM 9051 O  O   . HOH Q 4 .   ? 1.221   -38.817 8.037   1    34.41  ? 457 HOH A O   1 
HETATM 9052 O  O   . HOH Q 4 .   ? -26.673 -27.432 0.487   1    35.56  ? 458 HOH A O   1 
HETATM 9053 O  O   . HOH Q 4 .   ? -9.466  -46.89  -2.04   1    46.01  ? 459 HOH A O   1 
HETATM 9054 O  O   . HOH Q 4 .   ? -8.287  -48.54  16.108  1    36.35  ? 460 HOH A O   1 
HETATM 9055 O  O   . HOH Q 4 .   ? -15.842 -23.378 37.286  1    23.69  ? 461 HOH A O   1 
HETATM 9056 O  O   . HOH Q 4 .   ? 6.442   -29.053 -18.079 1    39.3   ? 462 HOH A O   1 
HETATM 9057 O  O   . HOH Q 4 .   ? -23.006 -26.651 4.983   1    37.46  ? 463 HOH A O   1 
HETATM 9058 O  O   . HOH Q 4 .   ? 11.662  -22.64  -1.489  1    22.84  ? 464 HOH A O   1 
HETATM 9059 O  O   . HOH Q 4 .   ? -22.328 -40.623 17.74   1    31.98  ? 465 HOH A O   1 
HETATM 9060 O  O   . HOH Q 4 .   ? 15.527  -27.362 1.875   1    42.91  ? 466 HOH A O   1 
HETATM 9061 O  O   . HOH Q 4 .   ? -3.211  -4.825  10.976  1    34.07  ? 467 HOH A O   1 
HETATM 9062 O  O   . HOH Q 4 .   ? -12.44  -10.846 5.459   1    28.97  ? 468 HOH A O   1 
HETATM 9063 O  O   . HOH Q 4 .   ? -12.805 -49.967 4.212   1    24.6   ? 469 HOH A O   1 
HETATM 9064 O  O   . HOH Q 4 .   ? -8.309  -33.293 -13.103 1    33.43  ? 470 HOH A O   1 
HETATM 9065 O  O   . HOH Q 4 .   ? -12.57  -28.83  -2.378  1    36.13  ? 471 HOH A O   1 
HETATM 9066 O  O   . HOH Q 4 .   ? -1.364  -23.233 23.686  1    59.99  ? 472 HOH A O   1 
HETATM 9067 O  O   . HOH Q 4 .   ? 9.474   -22.482 -8.152  1    40.7   ? 473 HOH A O   1 
HETATM 9068 O  O   . HOH Q 4 .   ? -15.948 -41.922 -2.835  1    32.64  ? 474 HOH A O   1 
HETATM 9069 O  O   . HOH Q 4 .   ? -12.083 -22.946 -10.701 1    32.5   ? 475 HOH A O   1 
HETATM 9070 O  O   . HOH Q 4 .   ? -1.267  -19.446 18.507  1    40.22  ? 476 HOH A O   1 
HETATM 9071 O  O   . HOH Q 4 .   ? -4.012  -35.726 27.09   1    39.98  ? 477 HOH A O   1 
HETATM 9072 O  O   . HOH Q 4 .   ? 10.901  -20.957 1.039   1    40.34  ? 478 HOH A O   1 
HETATM 9073 O  O   . HOH Q 4 .   ? -16.938 -32.882 -3.989  1    34.22  ? 479 HOH A O   1 
HETATM 9074 O  O   . HOH Q 4 .   ? 12.912  -34.814 7.557   1    37.33  ? 480 HOH A O   1 
HETATM 9075 O  O   . HOH Q 4 .   ? -4.566  -51.561 5.822   1    39.59  ? 481 HOH A O   1 
HETATM 9076 O  O   . HOH Q 4 .   ? 10.389  -37.246 0.466   1    33.22  ? 482 HOH A O   1 
HETATM 9077 O  O   . HOH Q 4 .   ? 0.407   -37.495 -10.261 1    25.18  ? 483 HOH A O   1 
HETATM 9078 O  O   . HOH Q 4 .   ? 12.78   -36.804 -13.684 1    36.37  ? 484 HOH A O   1 
HETATM 9079 O  O   . HOH Q 4 .   ? 1.796   -50.991 2.48    1    36.31  ? 485 HOH A O   1 
HETATM 9080 O  O   . HOH Q 4 .   ? 3.971   -40.991 3.29    1    44.68  ? 486 HOH A O   1 
HETATM 9081 O  O   . HOH Q 4 .   ? -14.692 -11.688 -8.442  1    31.37  ? 487 HOH A O   1 
HETATM 9082 O  O   . HOH Q 4 .   ? -4.879  -19.53  -10.663 1    29.84  ? 488 HOH A O   1 
HETATM 9083 O  O   . HOH Q 4 .   ? -17.995 -24.184 31.765  1    23.53  ? 489 HOH A O   1 
HETATM 9084 O  O   . HOH Q 4 .   ? 6.781   -19.716 3.078   1    39.91  ? 490 HOH A O   1 
HETATM 9085 O  O   . HOH Q 4 .   ? 2.768   -25.036 14.092  1    37.55  ? 491 HOH A O   1 
HETATM 9086 O  O   . HOH Q 4 .   ? -6.197  -25.128 26.201  1    58.86  ? 492 HOH A O   1 
HETATM 9087 O  O   . HOH Q 4 .   ? -6.524  -25.178 -11.021 1    37.16  ? 493 HOH A O   1 
HETATM 9088 O  O   . HOH Q 4 .   ? -4.964  -10.547 16.981  1    37.41  ? 494 HOH A O   1 
HETATM 9089 O  O   . HOH Q 4 .   ? -2.703  -19.4   -11.958 1    26.97  ? 495 HOH A O   1 
HETATM 9090 O  O   . HOH Q 4 .   ? 12.518  -32.614 -15.795 1    28.09  ? 496 HOH A O   1 
HETATM 9091 O  O   . HOH Q 4 .   ? -4.51   -36.144 -8.326  1    28.21  ? 497 HOH A O   1 
HETATM 9092 O  O   . HOH Q 4 .   ? -21.098 -36.805 -2.218  1    44.04  ? 498 HOH A O   1 
HETATM 9093 O  O   . HOH Q 4 .   ? -16.587 -25.055 28.9    1    40.08  ? 499 HOH A O   1 
HETATM 9094 O  O   . HOH Q 4 .   ? -16.493 -45.677 13.978  1    37.13  ? 500 HOH A O   1 
HETATM 9095 O  O   . HOH Q 4 .   ? -7.362  -51.555 6.823   1    44.3   ? 501 HOH A O   1 
HETATM 9096 O  O   . HOH Q 4 .   ? -8.324  -11.867 37.758  1    20.4   ? 502 HOH A O   1 
HETATM 9097 O  O   . HOH Q 4 .   ? 2.332   -25.061 22.935  1    64.34  ? 503 HOH A O   1 
HETATM 9098 O  O   . HOH Q 4 .   ? -2.096  -9.042  9.009   1    37.78  ? 504 HOH A O   1 
HETATM 9099 O  O   . HOH Q 4 .   ? -7.084  -44.418 -3.351  1    42.49  ? 505 HOH A O   1 
HETATM 9100 O  O   . HOH Q 4 .   ? -1.129  -53.385 -0.335  1    35.59  ? 506 HOH A O   1 
HETATM 9101 O  O   . HOH Q 4 .   ? -4.109  -11.875 8.636   1    39.34  ? 507 HOH A O   1 
HETATM 9102 O  O   . HOH Q 4 .   ? 3.362   -27.021 12.386  1    34.8   ? 508 HOH A O   1 
HETATM 9103 O  O   . HOH Q 4 .   ? -20.257 -15.366 28.159  1    45.44  ? 509 HOH A O   1 
HETATM 9104 O  O   . HOH Q 4 .   ? 13.96   -28.626 -18.23  1    35.92  ? 510 HOH A O   1 
HETATM 9105 O  O   . HOH Q 4 .   ? -3.734  -52.343 0.201   1    36.87  ? 511 HOH A O   1 
HETATM 9106 O  O   . HOH Q 4 .   ? 13.376  -31.323 -18.08  1    39.25  ? 512 HOH A O   1 
HETATM 9107 O  O   . HOH Q 4 .   ? -20.575 -36.281 16.571  1    38.41  ? 513 HOH A O   1 
HETATM 9108 O  O   . HOH Q 4 .   ? 10.807  -33.791 9.603   1    47.94  ? 514 HOH A O   1 
HETATM 9109 O  O   . HOH Q 4 .   ? -27.495 -21.471 10.382  1    43.96  ? 515 HOH A O   1 
HETATM 9110 O  O   . HOH Q 4 .   ? -0.345  -13.885 5.821   1    34.83  ? 516 HOH A O   1 
HETATM 9111 O  O   . HOH R 4 .   ? -29.24  9.43    -8.917  1    31.15  ? 801 HOH B O   1 
HETATM 9112 O  O   . HOH R 4 .   ? -30.01  17.662  7.749   1    42.79  ? 802 HOH B O   1 
HETATM 9113 O  O   . HOH R 4 .   ? -18.508 -0.446  -7.933  1    39.23  ? 803 HOH B O   1 
HETATM 9114 O  O   . HOH R 4 .   ? -13.844 -10.712 -0.312  1    31.38  ? 804 HOH B O   1 
HETATM 9115 O  O   . HOH R 4 .   ? -35.152 -3.016  -20.382 1    42.45  ? 805 HOH B O   1 
HETATM 9116 O  O   . HOH R 4 .   ? -26.213 2.499   13.878  1    46.49  ? 806 HOH B O   1 
HETATM 9117 O  O   . HOH R 4 .   ? -29.739 11.182  13.766  1    28.01  ? 807 HOH B O   1 
HETATM 9118 O  O   . HOH R 4 .   ? -8.605  2.059   16.859  1    36     ? 808 HOH B O   1 
HETATM 9119 O  O   . HOH R 4 .   ? -34.179 1.134   -25.667 1    34.98  ? 809 HOH B O   1 
HETATM 9120 O  O   . HOH R 4 .   ? -26.924 10.731  -12.083 1    36.26  ? 810 HOH B O   1 
HETATM 9121 O  O   . HOH R 4 .   ? -22.109 22.046  12.482  1    25.65  ? 811 HOH B O   1 
HETATM 9122 O  O   . HOH R 4 .   ? -27.344 12.548  -3.407  1    34.61  ? 812 HOH B O   1 
HETATM 9123 O  O   . HOH R 4 .   ? -26.542 15.382  11.999  1    31.16  ? 813 HOH B O   1 
HETATM 9124 O  O   . HOH R 4 .   ? -26.28  10.771  -0.633  1    34.41  ? 814 HOH B O   1 
HETATM 9125 O  O   . HOH R 4 .   ? -20.434 9.31    -21.165 1    35.7   ? 815 HOH B O   1 
HETATM 9126 O  O   . HOH R 4 .   ? -21.123 8.15    -17.866 1    24.12  ? 816 HOH B O   1 
HETATM 9127 O  O   . HOH R 4 .   ? -24.915 9.321   -8.5    1    31.36  ? 817 HOH B O   1 
HETATM 9128 O  O   . HOH R 4 .   ? -19.755 -12.979 -0.513  1    43.93  ? 818 HOH B O   1 
HETATM 9129 O  O   . HOH R 4 .   ? -17.8   -11.012 -4.768  1    36.9   ? 819 HOH B O   1 
HETATM 9130 O  O   . HOH R 4 .   ? -35.514 2.232   7.608   1    55.4   ? 820 HOH B O   1 
HETATM 9131 O  O   . HOH R 4 .   ? -5.827  -6.394  5.843   1    33.04  ? 821 HOH B O   1 
HETATM 9132 O  O   . HOH R 4 .   ? -22.651 -0.436  0.834   1    33.68  ? 822 HOH B O   1 
HETATM 9133 O  O   . HOH R 4 .   ? -12.623 3.658   -5.885  1    32.74  ? 823 HOH B O   1 
HETATM 9134 O  O   . HOH R 4 .   ? -32.731 -10.219 0.841   1    30.36  ? 824 HOH B O   1 
HETATM 9135 O  O   . HOH R 4 .   ? -28.747 -2.135  2.677   1    55.52  ? 825 HOH B O   1 
HETATM 9136 O  O   . HOH R 4 .   ? -16.414 16.593  7.609   1    30.14  ? 826 HOH B O   1 
HETATM 9137 O  O   . HOH R 4 .   ? -19.476 20.843  12.173  1    28.93  ? 827 HOH B O   1 
HETATM 9138 O  O   . HOH R 4 .   ? -25.552 -26.36  3.957   1    32.02  ? 828 HOH B O   1 
HETATM 9139 O  O   . HOH R 4 .   ? -16.674 14.677  -8.245  1    34.98  ? 829 HOH B O   1 
HETATM 9140 O  O   . HOH R 4 .   ? 4.049   -8.972  -2.107  1    39.08  ? 830 HOH B O   1 
HETATM 9141 O  O   . HOH R 4 .   ? -27.956 -4.28   3.522   1    47.89  ? 831 HOH B O   1 
HETATM 9142 O  O   . HOH R 4 .   ? -15.352 -27.534 1.108   1    15.83  ? 832 HOH B O   1 
HETATM 9143 O  O   . HOH R 4 .   ? -16.499 -8.376  1.743   1    28.42  ? 833 HOH B O   1 
HETATM 9144 O  O   . HOH R 4 .   ? -31.708 9.744   2.659   1    58.98  ? 834 HOH B O   1 
HETATM 9145 O  O   . HOH R 4 .   ? -29.994 11.535  -2.575  1    23.32  ? 835 HOH B O   1 
HETATM 9146 O  O   . HOH R 4 .   ? -15.204 -16.98  -12.944 1    41.55  ? 836 HOH B O   1 
HETATM 9147 O  O   . HOH R 4 .   ? -23.687 20.12   0.625   1    34.75  ? 837 HOH B O   1 
HETATM 9148 O  O   . HOH R 4 .   ? -23.197 -2.005  -1.731  1    36.64  ? 838 HOH B O   1 
HETATM 9149 O  O   . HOH R 4 .   ? -26.646 20.096  1.989   1    25.57  ? 839 HOH B O   1 
HETATM 9150 O  O   . HOH R 4 .   ? -18.081 -12.717 -11.89  1    37.57  ? 840 HOH B O   1 
HETATM 9151 O  O   . HOH R 4 .   ? -12.079 -3.383  -7.702  1    45.2   ? 841 HOH B O   1 
HETATM 9152 O  O   . HOH R 4 .   ? -6.461  -3.485  -3.97   1    35.71  ? 842 HOH B O   1 
HETATM 9153 O  O   . HOH R 4 .   ? 0.268   11.288  8.306   1    28.57  ? 843 HOH B O   1 
HETATM 9154 O  O   . HOH R 4 .   ? -25.045 -24.422 -1.543  1    33.07  ? 844 HOH B O   1 
HETATM 9155 O  O   . HOH R 4 .   ? -19.398 10.15   -8.4    1    42.56  ? 845 HOH B O   1 
HETATM 9156 O  O   . HOH R 4 .   ? -19.805 -9.387  10.682  1    30.54  ? 846 HOH B O   1 
HETATM 9157 O  O   . HOH R 4 .   ? -37.292 -2.653  -7.417  1    27.28  ? 847 HOH B O   1 
HETATM 9158 O  O   . HOH R 4 .   ? -30.552 -12.088 -5.066  1    36.71  ? 848 HOH B O   1 
HETATM 9159 O  O   . HOH R 4 .   ? -13.634 -5.306  -5.503  1    38.19  ? 849 HOH B O   1 
HETATM 9160 O  O   . HOH R 4 .   ? -12.015 9.205   -9.593  1    24.51  ? 850 HOH B O   1 
HETATM 9161 O  O   . HOH R 4 .   ? -21.343 -1.283  -26.525 1    30.69  ? 851 HOH B O   1 
HETATM 9162 O  O   . HOH R 4 .   ? -26.132 -2.214  11.763  1    47.62  ? 852 HOH B O   1 
HETATM 9163 O  O   . HOH R 4 .   ? -22.293 11.233  -12.071 1    36.18  ? 853 HOH B O   1 
HETATM 9164 O  O   . HOH R 4 .   ? -38.124 -11.062 -15.59  1    26.07  ? 854 HOH B O   1 
HETATM 9165 O  O   . HOH R 4 .   ? -24.376 -2.841  1.844   1    33.61  ? 855 HOH B O   1 
HETATM 9166 O  O   . HOH R 4 .   ? -28.821 -23.832 -0.482  1    52.6   ? 856 HOH B O   1 
HETATM 9167 O  O   . HOH R 4 .   ? -28.241 6.179   19.404  1    40.74  ? 857 HOH B O   1 
HETATM 9168 O  O   . HOH R 4 .   ? -31.456 -18.09  -18.396 1    33.94  ? 858 HOH B O   1 
HETATM 9169 O  O   . HOH R 4 .   ? -5.409  14.487  18.93   1    34.14  ? 859 HOH B O   1 
HETATM 9170 O  O   . HOH R 4 .   ? -31.812 3.428   -26.603 1    40.26  ? 860 HOH B O   1 
HETATM 9171 O  O   . HOH R 4 .   ? -33.152 7.887   1.53    1    44.13  ? 861 HOH B O   1 
HETATM 9172 O  O   . HOH R 4 .   ? -10.342 -6.891  -8.586  1    54.02  ? 862 HOH B O   1 
HETATM 9173 O  O   . HOH R 4 .   ? -31.847 11.113  -11.493 1    38.28  ? 863 HOH B O   1 
HETATM 9174 O  O   . HOH R 4 .   ? -18.471 -8.748  3.73    1    26.07  ? 864 HOH B O   1 
HETATM 9175 O  O   . HOH R 4 .   ? -20.33  -3.072  20.78   1    44.08  ? 865 HOH B O   1 
HETATM 9176 O  O   . HOH R 4 .   ? -25.448 -5.18   4.222   1    54.36  ? 866 HOH B O   1 
HETATM 9177 O  O   . HOH R 4 .   ? -30.966 15.628  2.696   1    30.64  ? 867 HOH B O   1 
HETATM 9178 O  O   . HOH R 4 .   ? -33.009 -16.388 -3.405  1    26.71  ? 868 HOH B O   1 
HETATM 9179 O  O   . HOH R 4 .   ? -13.973 5.539   20.989  1    33.39  ? 869 HOH B O   1 
HETATM 9180 O  O   . HOH R 4 .   ? -32.707 -11.787 -23.124 1    35.43  ? 870 HOH B O   1 
HETATM 9181 O  O   . HOH R 4 .   ? -24.251 -24.529 -4.053  1    28.41  ? 871 HOH B O   1 
HETATM 9182 O  O   . HOH R 4 .   ? -16.613 -8.953  -3.479  1    39.4   ? 872 HOH B O   1 
HETATM 9183 O  O   . HOH R 4 .   ? -30.118 -20.871 -11.45  1    42.93  ? 873 HOH B O   1 
HETATM 9184 O  O   . HOH R 4 .   ? -30.257 8.679   13.009  1    35.59  ? 874 HOH B O   1 
HETATM 9185 O  O   . HOH R 4 .   ? -35.651 -8.703  -1.411  1    26.23  ? 875 HOH B O   1 
HETATM 9186 O  O   . HOH R 4 .   ? -40.741 -15.106 -8.832  1    37.75  ? 876 HOH B O   1 
HETATM 9187 O  O   . HOH R 4 .   ? -7.155  -20.899 -10.4   1    38.15  ? 877 HOH B O   1 
HETATM 9188 O  O   . HOH R 4 .   ? -22.249 10.592  -8.77   1    23.09  ? 878 HOH B O   1 
HETATM 9189 O  O   . HOH R 4 .   ? -22.196 3.541   -26.776 1    47.22  ? 879 HOH B O   1 
HETATM 9190 O  O   . HOH R 4 .   ? -25.604 4.112   18.942  1    38.18  ? 880 HOH B O   1 
HETATM 9191 O  O   . HOH R 4 .   ? -23.099 -28.306 -7.115  1    29.61  ? 881 HOH B O   1 
HETATM 9192 O  O   . HOH R 4 .   ? -29.652 -13.022 -20.864 1    37.16  ? 882 HOH B O   1 
HETATM 9193 O  O   . HOH R 4 .   ? -26.37  16.358  -8.288  1    24.86  ? 883 HOH B O   1 
HETATM 9194 O  O   . HOH R 4 .   ? -11.508 18.201  14.514  1    23.65  ? 884 HOH B O   1 
HETATM 9195 O  O   . HOH R 4 .   ? -27.816 20.643  7.395   1    37.31  ? 885 HOH B O   1 
HETATM 9196 O  O   . HOH R 4 .   ? -35.498 -3.79   -1.986  1    46.22  ? 886 HOH B O   1 
HETATM 9197 O  O   . HOH R 4 .   ? -32.841 17.04   8.439   1    48.94  ? 887 HOH B O   1 
HETATM 9198 O  O   . HOH R 4 .   ? -24.305 -26.477 -8.225  1    36.05  ? 888 HOH B O   1 
HETATM 9199 O  O   . HOH R 4 .   ? -6.446  -6.676  -2.12   1    35.13  ? 889 HOH B O   1 
HETATM 9200 O  O   . HOH R 4 .   ? -28.62  15.546  17.568  1    28.56  ? 890 HOH B O   1 
HETATM 9201 O  O   . HOH R 4 .   ? -28.004 -19.338 5.952   1    49.73  ? 891 HOH B O   1 
HETATM 9202 O  O   . HOH R 4 .   ? -29.807 16.928  0.614   1    30.28  ? 892 HOH B O   1 
HETATM 9203 O  O   . HOH R 4 .   ? -34.025 -12.868 3.059   1    25.84  ? 893 HOH B O   1 
HETATM 9204 O  O   . HOH R 4 .   ? -19.756 -5.87   -26.721 1    29.72  ? 894 HOH B O   1 
HETATM 9205 O  O   . HOH R 4 .   ? -13.294 19.124  12.958  1    24.56  ? 895 HOH B O   1 
HETATM 9206 O  O   . HOH R 4 .   ? -16.938 -26.388 -3.808  1    21.66  ? 896 HOH B O   1 
HETATM 9207 O  O   . HOH R 4 .   ? -26.887 15.618  -3.523  1    38.5   ? 897 HOH B O   1 
HETATM 9208 O  O   . HOH R 4 .   ? -23.982 -20.425 -13.206 1    48.84  ? 898 HOH B O   1 
HETATM 9209 O  O   . HOH R 4 .   ? -16.525 -10.433 -0.016  1    49.95  ? 899 HOH B O   1 
HETATM 9210 O  O   . HOH R 4 .   ? -26.214 -20.53  -15.297 1    39.95  ? 900 HOH B O   1 
HETATM 9211 O  O   . HOH R 4 .   ? -18.554 -15.719 -16.516 1    43.89  ? 901 HOH B O   1 
HETATM 9212 O  O   . HOH R 4 .   ? -24.672 10.067  -11.217 1    27.33  ? 902 HOH B O   1 
HETATM 9213 O  O   . HOH R 4 .   ? -38.027 -10.096 -2.154  1    40.57  ? 903 HOH B O   1 
HETATM 9214 O  O   . HOH R 4 .   ? -37.549 -15.656 -17.632 1    35.2   ? 904 HOH B O   1 
HETATM 9215 O  O   . HOH R 4 .   ? -16.167 -11.223 -10.601 1    32.93  ? 905 HOH B O   1 
HETATM 9216 O  O   . HOH R 4 .   ? -36.618 -6.496  -1.7    1    34.32  ? 906 HOH B O   1 
HETATM 9217 O  O   . HOH S 4 .   ? -20.288 1.548   44.084  1    33.11  ? 401 HOH C O   1 
HETATM 9218 O  O   . HOH S 4 .   ? -39.804 2.102   41.338  1    34.56  ? 402 HOH C O   1 
HETATM 9219 O  O   . HOH S 4 .   ? -16.274 0.678   31.578  1    39.27  ? 403 HOH C O   1 
HETATM 9220 O  O   . HOH S 4 .   ? -28.756 13.529  19.396  1    40.35  ? 404 HOH C O   1 
HETATM 9221 O  O   . HOH S 4 .   ? -27.492 9.988   18.061  1    30.84  ? 405 HOH C O   1 
HETATM 9222 O  O   . HOH S 4 .   ? -28.673 15.527  21.138  1    34.92  ? 406 HOH C O   1 
HETATM 9223 O  O   . HOH S 4 .   ? -44.246 6.916   44.018  1    36.78  ? 407 HOH C O   1 
HETATM 9224 O  O   . HOH S 4 .   ? -23.04  0.647   25.224  1    52.52  ? 408 HOH C O   1 
HETATM 9225 O  O   . HOH S 4 .   ? -44.429 24.253  17.035  1    42.65  ? 409 HOH C O   1 
HETATM 9226 O  O   . HOH S 4 .   ? -53.996 1.703   38.902  1    38.35  ? 410 HOH C O   1 
HETATM 9227 O  O   . HOH S 4 .   ? -22.737 10.571  21.599  1    22.85  ? 411 HOH C O   1 
HETATM 9228 O  O   . HOH S 4 .   ? -24.412 0.173   48.512  1    14.35  ? 412 HOH C O   1 
HETATM 9229 O  O   . HOH S 4 .   ? -57.486 7.645   28.129  1    35.72  ? 413 HOH C O   1 
HETATM 9230 O  O   . HOH S 4 .   ? -22.997 10.876  17.928  1    22.8   ? 414 HOH C O   1 
HETATM 9231 O  O   . HOH S 4 .   ? -54.69  18.949  39.665  1    28.12  ? 415 HOH C O   1 
HETATM 9232 O  O   . HOH S 4 .   ? -36.973 31.134  32.246  1    30.76  ? 416 HOH C O   1 
HETATM 9233 O  O   . HOH S 4 .   ? -41.98  37.57   28.957  1    24.94  ? 417 HOH C O   1 
HETATM 9234 O  O   . HOH S 4 .   ? -35.463 0.463   43.901  1    29.9   ? 418 HOH C O   1 
HETATM 9235 O  O   . HOH S 4 .   ? -38.097 8.419   21.407  1    50.59  ? 419 HOH C O   1 
HETATM 9236 O  O   . HOH S 4 .   ? -37.563 11.749  20.035  1    43.36  ? 420 HOH C O   1 
HETATM 9237 O  O   . HOH S 4 .   ? -57.85  7.197   36.141  1    29.47  ? 421 HOH C O   1 
HETATM 9238 O  O   . HOH S 4 .   ? -39.081 -0.148  44.416  1    30.04  ? 422 HOH C O   1 
HETATM 9239 O  O   . HOH S 4 .   ? -49.007 3.12    46.964  1    38.09  ? 423 HOH C O   1 
HETATM 9240 O  O   . HOH S 4 .   ? -42.058 1.18    43.027  1    27.95  ? 424 HOH C O   1 
HETATM 9241 O  O   . HOH S 4 .   ? -41.641 45.134  24.153  1    56.05  ? 425 HOH C O   1 
HETATM 9242 O  O   . HOH S 4 .   ? -54.1   2.329   41.349  1    42.94  ? 426 HOH C O   1 
HETATM 9243 O  O   . HOH S 4 .   ? -42.555 9.231   34.876  1    30.99  ? 427 HOH C O   1 
HETATM 9244 O  O   . HOH S 4 .   ? -29.338 18.005  20.364  1    36.59  ? 428 HOH C O   1 
HETATM 9245 O  O   . HOH S 4 .   ? -43.453 -1.016  35.011  1    32.31  ? 429 HOH C O   1 
HETATM 9246 O  O   . HOH S 4 .   ? -21.428 -0.129  28.992  1    38.07  ? 430 HOH C O   1 
HETATM 9247 O  O   . HOH S 4 .   ? -49.178 12.696  34.603  1    34.04  ? 431 HOH C O   1 
HETATM 9248 O  O   . HOH S 4 .   ? -47.719 10.681  16.006  1    37.13  ? 432 HOH C O   1 
HETATM 9249 O  O   . HOH S 4 .   ? -32.492 22.556  21.401  1    37.78  ? 433 HOH C O   1 
HETATM 9250 O  O   . HOH S 4 .   ? -52.341 22.878  37.901  1    32.11  ? 434 HOH C O   1 
HETATM 9251 O  O   . HOH S 4 .   ? -62.573 9.602   25.096  1    24.1   ? 435 HOH C O   1 
HETATM 9252 O  O   . HOH S 4 .   ? -18.841 6.829   23.022  1    15.72  ? 436 HOH C O   1 
HETATM 9253 O  O   . HOH S 4 .   ? -38.968 8.969   16.632  1    34.82  ? 437 HOH C O   1 
HETATM 9254 O  O   . HOH S 4 .   ? -33.778 18.053  36.333  1    64.21  ? 438 HOH C O   1 
HETATM 9255 O  O   . HOH S 4 .   ? -31.896 21.215  29.175  1    61.16  ? 439 HOH C O   1 
HETATM 9256 O  O   . HOH S 4 .   ? -44.54  15.738  15.8    1    42.51  ? 440 HOH C O   1 
HETATM 9257 O  O   . HOH S 4 .   ? -29.527 -1.168  22.807  1    69.05  ? 441 HOH C O   1 
HETATM 9258 O  O   . HOH S 4 .   ? -15.179 15.47   30.617  1    23.81  ? 442 HOH C O   1 
HETATM 9259 O  O   . HOH S 4 .   ? -26.033 8.338   19.723  1    30.75  ? 443 HOH C O   1 
HETATM 9260 O  O   . HOH S 4 .   ? -26.509 17.26   18.392  1    36.72  ? 444 HOH C O   1 
HETATM 9261 O  O   . HOH S 4 .   ? -34.652 -1.279  21.5    1    40.89  ? 445 HOH C O   1 
HETATM 9262 O  O   . HOH S 4 .   ? -24.235 8.55    22.234  1    29.55  ? 446 HOH C O   1 
HETATM 9263 O  O   . HOH S 4 .   ? -58.846 5.174   27.203  1    18.26  ? 447 HOH C O   1 
HETATM 9264 O  O   . HOH S 4 .   ? -31.669 12.184  18.865  1    40.46  ? 448 HOH C O   1 
HETATM 9265 O  O   . HOH S 4 .   ? -40.835 3.412   44.821  1    41.72  ? 449 HOH C O   1 
HETATM 9266 O  O   . HOH T 4 .   ? -45.556 -6.677  33.806  1    29.68  ? 601 HOH D O   1 
HETATM 9267 O  O   . HOH T 4 .   ? -24.815 -25.161 31.62   1    32.15  ? 602 HOH D O   1 
HETATM 9268 O  O   . HOH T 4 .   ? -40.753 -1.393  42.574  1    25.6   ? 603 HOH D O   1 
HETATM 9269 O  O   . HOH T 4 .   ? -39.884 -29.916 30.983  1    32.33  ? 604 HOH D O   1 
HETATM 9270 O  O   . HOH T 4 .   ? -26.951 -4.531  41.099  1    46.25  ? 605 HOH D O   1 
HETATM 9271 O  O   . HOH T 4 .   ? -28.211 -23.287 42.317  1    20.38  ? 606 HOH D O   1 
HETATM 9272 O  O   . HOH T 4 .   ? -59.866 4.959   36.905  1    33.8   ? 607 HOH D O   1 
HETATM 9273 O  O   . HOH T 4 .   ? -47.916 -7.846  45.891  1    27.04  ? 608 HOH D O   1 
HETATM 9274 O  O   . HOH T 4 .   ? -33.134 -32.27  38.814  1    20.67  ? 609 HOH D O   1 
HETATM 9275 O  O   . HOH T 4 .   ? -31.439 -5.135  51.638  1    21.28  ? 610 HOH D O   1 
HETATM 9276 O  O   . HOH T 4 .   ? -28.467 -23.416 45.045  1    34.01  ? 611 HOH D O   1 
HETATM 9277 O  O   . HOH T 4 .   ? -46.194 -17.471 44.026  1    32.1   ? 612 HOH D O   1 
HETATM 9278 O  O   . HOH T 4 .   ? -38.517 -26.87  33.347  1    30.76  ? 613 HOH D O   1 
HETATM 9279 O  O   . HOH T 4 .   ? -45.771 -4.649  46.561  1    28.63  ? 614 HOH D O   1 
HETATM 9280 O  O   . HOH T 4 .   ? -38.604 -3.876  28.016  1    30.05  ? 615 HOH D O   1 
HETATM 9281 O  O   . HOH T 4 .   ? -53.424 -32.527 46.962  1    32.73  ? 616 HOH D O   1 
HETATM 9282 O  O   . HOH T 4 .   ? -38.339 -26.239 44.658  1    28.18  ? 617 HOH D O   1 
HETATM 9283 O  O   . HOH T 4 .   ? -42.96  -28.43  45.751  1    24.42  ? 618 HOH D O   1 
HETATM 9284 O  O   . HOH T 4 .   ? -21.877 -25.706 40.057  1    41.82  ? 619 HOH D O   1 
HETATM 9285 O  O   . HOH T 4 .   ? -56.244 0.546   20.54   1    34.8   ? 620 HOH D O   1 
HETATM 9286 O  O   . HOH T 4 .   ? -22.102 -7.761  37.399  1    33.54  ? 621 HOH D O   1 
HETATM 9287 O  O   . HOH T 4 .   ? -33.63  -10.923 25.623  1    43.71  ? 622 HOH D O   1 
HETATM 9288 O  O   . HOH T 4 .   ? -43.171 -15.95  31.521  1    41.18  ? 623 HOH D O   1 
HETATM 9289 O  O   . HOH T 4 .   ? -51.303 -12.408 42.982  1    39.58  ? 624 HOH D O   1 
HETATM 9290 O  O   . HOH T 4 .   ? -50.323 -10.151 38.916  1    29.48  ? 625 HOH D O   1 
HETATM 9291 O  O   . HOH T 4 .   ? -44.019 -6.304  31.282  1    35.91  ? 626 HOH D O   1 
HETATM 9292 O  O   . HOH T 4 .   ? -34.822 -32.746 32.861  1    41.17  ? 627 HOH D O   1 
HETATM 9293 O  O   . HOH T 4 .   ? -20.31  -23.364 27.935  1    33.02  ? 628 HOH D O   1 
HETATM 9294 O  O   . HOH T 4 .   ? -53.32  -13.347 21.671  1    22.05  ? 629 HOH D O   1 
HETATM 9295 O  O   . HOH T 4 .   ? -30.482 -30.934 29.287  1    41.44  ? 630 HOH D O   1 
HETATM 9296 O  O   . HOH T 4 .   ? -45.409 -28.412 38.836  1    32.98  ? 631 HOH D O   1 
HETATM 9297 O  O   . HOH T 4 .   ? -48.76  -18.285 18.118  1    33.31  ? 632 HOH D O   1 
HETATM 9298 O  O   . HOH T 4 .   ? -48.883 -31.329 21.333  1    31.5   ? 633 HOH D O   1 
HETATM 9299 O  O   . HOH T 4 .   ? -47.759 -4.544  43.553  1    27.37  ? 634 HOH D O   1 
HETATM 9300 O  O   . HOH T 4 .   ? -46.471 -20.01  19.36   1    29.62  ? 635 HOH D O   1 
HETATM 9301 O  O   . HOH T 4 .   ? -37.962 -32.789 31.103  1    25.11  ? 636 HOH D O   1 
HETATM 9302 O  O   . HOH T 4 .   ? -23.117 -19.64  24.96   1    34.33  ? 637 HOH D O   1 
# 
