data_9ESU
# 
_entry.id   9ESU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9ESU         pdb_00009esu 10.2210/pdb9esu/pdb 
WWPDB D_1292137167 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-09 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9ESU 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-26 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 jane.endicott@newcastle.ac.uk Jane    Endicott A.   'principal investigator/group leader' 0000-0003-4868-0116 
4 martin.noble@newcastle.ac.uk  Martin  Noble    E.M. 'principal investigator/group leader' 0000-0002-3595-9807 
5 mike.waring@newcastle.ac.uk   Michael Waring   J.   'principal investigator/group leader' 0000-0002-9110-8783 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hope, I.'       1 0000-0002-8002-5026 
'Martin, M.P.'   2 0000-0003-4810-3351 
'Waring, M.J.'   3 0000-0002-9110-8783 
'Noble, M.E.M.'  4 0000-0002-3595-9807 
'Endicott, J.A.' 5 0000-0003-4868-0116 
'Tatum, N.J.'    6 0000-0003-3878-9265 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hope, I.'       1 0000-0002-8002-5026 
primary 'Martin, M.P.'   2 0000-0003-4810-3351 
primary 'Waring, M.J.'   3 0000-0002-9110-8783 
primary 'Noble, M.E.M.'  4 0000-0002-3595-9807 
primary 'Endicott, J.A.' 5 0000-0003-4868-0116 
primary 'Tatum, N.J.'    6 0000-0003-3878-9265 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Cyclin-dependent kinase 2'            34354.770 2   2.7.11.22 ? ? ? 
2 polymer     man Cyclin-A2                              30817.473 2   ?         ? ? ? 
3 non-polymer nat '4-bromanyl-2-(methoxymethyl)pyridine' 202.049   2   ?         ? ? ? 
4 water       nat water                                  18.015    464 ?         ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'Cell division protein kinase 2,p33 protein kinase' 
2 Cyclin-A                                            
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no yes 
;GPGSMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKL
YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV
RTY(TPO)HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS
MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
;
;GPGSMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKL
YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV
RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY
KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
;
A,C ? 
2 'polypeptide(L)' no no  
;GVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLR
GKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVE
SLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIR
EKYKNSKYHGVSLLNPPETLNVHHHHHH
;
;GVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLR
GKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVE
SLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIR
EKYKNSKYHGVSLLNPPETLNVHHHHHH
;
B,D ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '4-bromanyl-2-(methoxymethyl)pyridine' IJU 
4 water                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   SER n 
1 5   MET n 
1 6   GLU n 
1 7   ASN n 
1 8   PHE n 
1 9   GLN n 
1 10  LYS n 
1 11  VAL n 
1 12  GLU n 
1 13  LYS n 
1 14  ILE n 
1 15  GLY n 
1 16  GLU n 
1 17  GLY n 
1 18  THR n 
1 19  TYR n 
1 20  GLY n 
1 21  VAL n 
1 22  VAL n 
1 23  TYR n 
1 24  LYS n 
1 25  ALA n 
1 26  ARG n 
1 27  ASN n 
1 28  LYS n 
1 29  LEU n 
1 30  THR n 
1 31  GLY n 
1 32  GLU n 
1 33  VAL n 
1 34  VAL n 
1 35  ALA n 
1 36  LEU n 
1 37  LYS n 
1 38  LYS n 
1 39  ILE n 
1 40  ARG n 
1 41  LEU n 
1 42  ASP n 
1 43  THR n 
1 44  GLU n 
1 45  THR n 
1 46  GLU n 
1 47  GLY n 
1 48  VAL n 
1 49  PRO n 
1 50  SER n 
1 51  THR n 
1 52  ALA n 
1 53  ILE n 
1 54  ARG n 
1 55  GLU n 
1 56  ILE n 
1 57  SER n 
1 58  LEU n 
1 59  LEU n 
1 60  LYS n 
1 61  GLU n 
1 62  LEU n 
1 63  ASN n 
1 64  HIS n 
1 65  PRO n 
1 66  ASN n 
1 67  ILE n 
1 68  VAL n 
1 69  LYS n 
1 70  LEU n 
1 71  LEU n 
1 72  ASP n 
1 73  VAL n 
1 74  ILE n 
1 75  HIS n 
1 76  THR n 
1 77  GLU n 
1 78  ASN n 
1 79  LYS n 
1 80  LEU n 
1 81  TYR n 
1 82  LEU n 
1 83  VAL n 
1 84  PHE n 
1 85  GLU n 
1 86  PHE n 
1 87  LEU n 
1 88  HIS n 
1 89  GLN n 
1 90  ASP n 
1 91  LEU n 
1 92  LYS n 
1 93  LYS n 
1 94  PHE n 
1 95  MET n 
1 96  ASP n 
1 97  ALA n 
1 98  SER n 
1 99  ALA n 
1 100 LEU n 
1 101 THR n 
1 102 GLY n 
1 103 ILE n 
1 104 PRO n 
1 105 LEU n 
1 106 PRO n 
1 107 LEU n 
1 108 ILE n 
1 109 LYS n 
1 110 SER n 
1 111 TYR n 
1 112 LEU n 
1 113 PHE n 
1 114 GLN n 
1 115 LEU n 
1 116 LEU n 
1 117 GLN n 
1 118 GLY n 
1 119 LEU n 
1 120 ALA n 
1 121 PHE n 
1 122 CYS n 
1 123 HIS n 
1 124 SER n 
1 125 HIS n 
1 126 ARG n 
1 127 VAL n 
1 128 LEU n 
1 129 HIS n 
1 130 ARG n 
1 131 ASP n 
1 132 LEU n 
1 133 LYS n 
1 134 PRO n 
1 135 GLN n 
1 136 ASN n 
1 137 LEU n 
1 138 LEU n 
1 139 ILE n 
1 140 ASN n 
1 141 THR n 
1 142 GLU n 
1 143 GLY n 
1 144 ALA n 
1 145 ILE n 
1 146 LYS n 
1 147 LEU n 
1 148 ALA n 
1 149 ASP n 
1 150 PHE n 
1 151 GLY n 
1 152 LEU n 
1 153 ALA n 
1 154 ARG n 
1 155 ALA n 
1 156 PHE n 
1 157 GLY n 
1 158 VAL n 
1 159 PRO n 
1 160 VAL n 
1 161 ARG n 
1 162 THR n 
1 163 TYR n 
1 164 TPO n 
1 165 HIS n 
1 166 GLU n 
1 167 VAL n 
1 168 VAL n 
1 169 THR n 
1 170 LEU n 
1 171 TRP n 
1 172 TYR n 
1 173 ARG n 
1 174 ALA n 
1 175 PRO n 
1 176 GLU n 
1 177 ILE n 
1 178 LEU n 
1 179 LEU n 
1 180 GLY n 
1 181 CYS n 
1 182 LYS n 
1 183 TYR n 
1 184 TYR n 
1 185 SER n 
1 186 THR n 
1 187 ALA n 
1 188 VAL n 
1 189 ASP n 
1 190 ILE n 
1 191 TRP n 
1 192 SER n 
1 193 LEU n 
1 194 GLY n 
1 195 CYS n 
1 196 ILE n 
1 197 PHE n 
1 198 ALA n 
1 199 GLU n 
1 200 MET n 
1 201 VAL n 
1 202 THR n 
1 203 ARG n 
1 204 ARG n 
1 205 ALA n 
1 206 LEU n 
1 207 PHE n 
1 208 PRO n 
1 209 GLY n 
1 210 ASP n 
1 211 SER n 
1 212 GLU n 
1 213 ILE n 
1 214 ASP n 
1 215 GLN n 
1 216 LEU n 
1 217 PHE n 
1 218 ARG n 
1 219 ILE n 
1 220 PHE n 
1 221 ARG n 
1 222 THR n 
1 223 LEU n 
1 224 GLY n 
1 225 THR n 
1 226 PRO n 
1 227 ASP n 
1 228 GLU n 
1 229 VAL n 
1 230 VAL n 
1 231 TRP n 
1 232 PRO n 
1 233 GLY n 
1 234 VAL n 
1 235 THR n 
1 236 SER n 
1 237 MET n 
1 238 PRO n 
1 239 ASP n 
1 240 TYR n 
1 241 LYS n 
1 242 PRO n 
1 243 SER n 
1 244 PHE n 
1 245 PRO n 
1 246 LYS n 
1 247 TRP n 
1 248 ALA n 
1 249 ARG n 
1 250 GLN n 
1 251 ASP n 
1 252 PHE n 
1 253 SER n 
1 254 LYS n 
1 255 VAL n 
1 256 VAL n 
1 257 PRO n 
1 258 PRO n 
1 259 LEU n 
1 260 ASP n 
1 261 GLU n 
1 262 ASP n 
1 263 GLY n 
1 264 ARG n 
1 265 SER n 
1 266 LEU n 
1 267 LEU n 
1 268 SER n 
1 269 GLN n 
1 270 MET n 
1 271 LEU n 
1 272 HIS n 
1 273 TYR n 
1 274 ASP n 
1 275 PRO n 
1 276 ASN n 
1 277 LYS n 
1 278 ARG n 
1 279 ILE n 
1 280 SER n 
1 281 ALA n 
1 282 LYS n 
1 283 ALA n 
1 284 ALA n 
1 285 LEU n 
1 286 ALA n 
1 287 HIS n 
1 288 PRO n 
1 289 PHE n 
1 290 PHE n 
1 291 GLN n 
1 292 ASP n 
1 293 VAL n 
1 294 THR n 
1 295 LYS n 
1 296 PRO n 
1 297 VAL n 
1 298 PRO n 
1 299 HIS n 
1 300 LEU n 
1 301 ARG n 
1 302 LEU n 
2 1   GLY n 
2 2   VAL n 
2 3   ASN n 
2 4   GLU n 
2 5   VAL n 
2 6   PRO n 
2 7   ASP n 
2 8   TYR n 
2 9   HIS n 
2 10  GLU n 
2 11  ASP n 
2 12  ILE n 
2 13  HIS n 
2 14  THR n 
2 15  TYR n 
2 16  LEU n 
2 17  ARG n 
2 18  GLU n 
2 19  MET n 
2 20  GLU n 
2 21  VAL n 
2 22  LYS n 
2 23  CYS n 
2 24  LYS n 
2 25  PRO n 
2 26  LYS n 
2 27  VAL n 
2 28  GLY n 
2 29  TYR n 
2 30  MET n 
2 31  LYS n 
2 32  LYS n 
2 33  GLN n 
2 34  PRO n 
2 35  ASP n 
2 36  ILE n 
2 37  THR n 
2 38  ASN n 
2 39  SER n 
2 40  MET n 
2 41  ARG n 
2 42  ALA n 
2 43  ILE n 
2 44  LEU n 
2 45  VAL n 
2 46  ASP n 
2 47  TRP n 
2 48  LEU n 
2 49  VAL n 
2 50  GLU n 
2 51  VAL n 
2 52  GLY n 
2 53  GLU n 
2 54  GLU n 
2 55  TYR n 
2 56  LYS n 
2 57  LEU n 
2 58  GLN n 
2 59  ASN n 
2 60  GLU n 
2 61  THR n 
2 62  LEU n 
2 63  HIS n 
2 64  LEU n 
2 65  ALA n 
2 66  VAL n 
2 67  ASN n 
2 68  TYR n 
2 69  ILE n 
2 70  ASP n 
2 71  ARG n 
2 72  PHE n 
2 73  LEU n 
2 74  SER n 
2 75  SER n 
2 76  MET n 
2 77  SER n 
2 78  VAL n 
2 79  LEU n 
2 80  ARG n 
2 81  GLY n 
2 82  LYS n 
2 83  LEU n 
2 84  GLN n 
2 85  LEU n 
2 86  VAL n 
2 87  GLY n 
2 88  THR n 
2 89  ALA n 
2 90  ALA n 
2 91  MET n 
2 92  LEU n 
2 93  LEU n 
2 94  ALA n 
2 95  SER n 
2 96  LYS n 
2 97  PHE n 
2 98  GLU n 
2 99  GLU n 
2 100 ILE n 
2 101 TYR n 
2 102 PRO n 
2 103 PRO n 
2 104 GLU n 
2 105 VAL n 
2 106 ALA n 
2 107 GLU n 
2 108 PHE n 
2 109 VAL n 
2 110 TYR n 
2 111 ILE n 
2 112 THR n 
2 113 ASP n 
2 114 ASP n 
2 115 THR n 
2 116 TYR n 
2 117 THR n 
2 118 LYS n 
2 119 LYS n 
2 120 GLN n 
2 121 VAL n 
2 122 LEU n 
2 123 ARG n 
2 124 MET n 
2 125 GLU n 
2 126 HIS n 
2 127 LEU n 
2 128 VAL n 
2 129 LEU n 
2 130 LYS n 
2 131 VAL n 
2 132 LEU n 
2 133 ALA n 
2 134 PHE n 
2 135 ASP n 
2 136 LEU n 
2 137 ALA n 
2 138 ALA n 
2 139 PRO n 
2 140 THR n 
2 141 ILE n 
2 142 ASN n 
2 143 GLN n 
2 144 PHE n 
2 145 LEU n 
2 146 THR n 
2 147 GLN n 
2 148 TYR n 
2 149 PHE n 
2 150 LEU n 
2 151 HIS n 
2 152 GLN n 
2 153 GLN n 
2 154 PRO n 
2 155 ALA n 
2 156 ASN n 
2 157 CYS n 
2 158 LYS n 
2 159 VAL n 
2 160 GLU n 
2 161 SER n 
2 162 LEU n 
2 163 ALA n 
2 164 MET n 
2 165 PHE n 
2 166 LEU n 
2 167 GLY n 
2 168 GLU n 
2 169 LEU n 
2 170 SER n 
2 171 LEU n 
2 172 ILE n 
2 173 ASP n 
2 174 ALA n 
2 175 ASP n 
2 176 PRO n 
2 177 TYR n 
2 178 LEU n 
2 179 LYS n 
2 180 TYR n 
2 181 LEU n 
2 182 PRO n 
2 183 SER n 
2 184 VAL n 
2 185 ILE n 
2 186 ALA n 
2 187 ALA n 
2 188 ALA n 
2 189 ALA n 
2 190 PHE n 
2 191 HIS n 
2 192 LEU n 
2 193 ALA n 
2 194 LEU n 
2 195 TYR n 
2 196 THR n 
2 197 VAL n 
2 198 THR n 
2 199 GLY n 
2 200 GLN n 
2 201 SER n 
2 202 TRP n 
2 203 PRO n 
2 204 GLU n 
2 205 SER n 
2 206 LEU n 
2 207 VAL n 
2 208 GLN n 
2 209 LYS n 
2 210 THR n 
2 211 GLY n 
2 212 TYR n 
2 213 THR n 
2 214 LEU n 
2 215 GLU n 
2 216 THR n 
2 217 LEU n 
2 218 LYS n 
2 219 PRO n 
2 220 CYS n 
2 221 LEU n 
2 222 LEU n 
2 223 ASP n 
2 224 LEU n 
2 225 HIS n 
2 226 GLN n 
2 227 THR n 
2 228 TYR n 
2 229 LEU n 
2 230 ARG n 
2 231 ALA n 
2 232 PRO n 
2 233 GLN n 
2 234 HIS n 
2 235 ALA n 
2 236 GLN n 
2 237 GLN n 
2 238 SER n 
2 239 ILE n 
2 240 ARG n 
2 241 GLU n 
2 242 LYS n 
2 243 TYR n 
2 244 LYS n 
2 245 ASN n 
2 246 SER n 
2 247 LYS n 
2 248 TYR n 
2 249 HIS n 
2 250 GLY n 
2 251 VAL n 
2 252 SER n 
2 253 LEU n 
2 254 LEU n 
2 255 ASN n 
2 256 PRO n 
2 257 PRO n 
2 258 GLU n 
2 259 THR n 
2 260 LEU n 
2 261 ASN n 
2 262 VAL n 
2 263 HIS n 
2 264 HIS n 
2 265 HIS n 
2 266 HIS n 
2 267 HIS n 
2 268 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 302 human  ? 'CDK2, CDKN2' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? PGEX6P1 ? ? 
2 1 sample 'Biological sequence' 1 268 cattle ? CCNA2         ? ? ? ? ? ? 'Bos taurus'   9913 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? PET21d  ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                ?                  'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                               ?                  'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                             ?                  'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                        ?                  'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                               ?                  'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                              ?                  'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                        ?                  'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                ?                  'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                              ?                  'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                  ?                  'H2 O'           18.015  
IJU non-polymer         . '4-bromanyl-2-(methoxymethyl)pyridine' ?                  'C7 H8 Br N O'   202.049 
ILE 'L-peptide linking' y ISOLEUCINE                             ?                  'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                ?                  'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                 ?                  'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                             ?                  'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                          ?                  'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                ?                  'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                 ?                  'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                              ?                  'C4 H9 N O3'     119.119 
TPO 'L-peptide linking' n PHOSPHOTHREONINE                       PHOSPHONOTHREONINE 'C4 H10 N O6 P'  199.099 
TRP 'L-peptide linking' y TRYPTOPHAN                             ?                  'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                               ?                  'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                 ?                  'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -3  -3  GLY GLY A . n 
A 1 2   PRO 2   -2  -2  PRO PRO A . n 
A 1 3   GLY 3   -1  -1  GLY GLY A . n 
A 1 4   SER 4   0   0   SER SER A . n 
A 1 5   MET 5   1   1   MET MET A . n 
A 1 6   GLU 6   2   2   GLU GLU A . n 
A 1 7   ASN 7   3   3   ASN ASN A . n 
A 1 8   PHE 8   4   4   PHE PHE A . n 
A 1 9   GLN 9   5   5   GLN GLN A . n 
A 1 10  LYS 10  6   6   LYS LYS A . n 
A 1 11  VAL 11  7   7   VAL VAL A . n 
A 1 12  GLU 12  8   8   GLU GLU A . n 
A 1 13  LYS 13  9   9   LYS LYS A . n 
A 1 14  ILE 14  10  10  ILE ILE A . n 
A 1 15  GLY 15  11  11  GLY GLY A . n 
A 1 16  GLU 16  12  12  GLU GLU A . n 
A 1 17  GLY 17  13  13  GLY GLY A . n 
A 1 18  THR 18  14  14  THR THR A . n 
A 1 19  TYR 19  15  15  TYR TYR A . n 
A 1 20  GLY 20  16  16  GLY GLY A . n 
A 1 21  VAL 21  17  17  VAL VAL A . n 
A 1 22  VAL 22  18  18  VAL VAL A . n 
A 1 23  TYR 23  19  19  TYR TYR A . n 
A 1 24  LYS 24  20  20  LYS LYS A . n 
A 1 25  ALA 25  21  21  ALA ALA A . n 
A 1 26  ARG 26  22  22  ARG ARG A . n 
A 1 27  ASN 27  23  23  ASN ASN A . n 
A 1 28  LYS 28  24  24  LYS LYS A . n 
A 1 29  LEU 29  25  25  LEU LEU A . n 
A 1 30  THR 30  26  26  THR THR A . n 
A 1 31  GLY 31  27  27  GLY GLY A . n 
A 1 32  GLU 32  28  28  GLU GLU A . n 
A 1 33  VAL 33  29  29  VAL VAL A . n 
A 1 34  VAL 34  30  30  VAL VAL A . n 
A 1 35  ALA 35  31  31  ALA ALA A . n 
A 1 36  LEU 36  32  32  LEU LEU A . n 
A 1 37  LYS 37  33  33  LYS LYS A . n 
A 1 38  LYS 38  34  34  LYS LYS A . n 
A 1 39  ILE 39  35  35  ILE ILE A . n 
A 1 40  ARG 40  36  36  ARG ARG A . n 
A 1 41  LEU 41  37  37  LEU LEU A . n 
A 1 42  ASP 42  38  38  ASP ASP A . n 
A 1 43  THR 43  39  39  THR THR A . n 
A 1 44  GLU 44  40  40  GLU GLU A . n 
A 1 45  THR 45  41  41  THR THR A . n 
A 1 46  GLU 46  42  42  GLU GLU A . n 
A 1 47  GLY 47  43  43  GLY GLY A . n 
A 1 48  VAL 48  44  44  VAL VAL A . n 
A 1 49  PRO 49  45  45  PRO PRO A . n 
A 1 50  SER 50  46  46  SER SER A . n 
A 1 51  THR 51  47  47  THR THR A . n 
A 1 52  ALA 52  48  48  ALA ALA A . n 
A 1 53  ILE 53  49  49  ILE ILE A . n 
A 1 54  ARG 54  50  50  ARG ARG A . n 
A 1 55  GLU 55  51  51  GLU GLU A . n 
A 1 56  ILE 56  52  52  ILE ILE A . n 
A 1 57  SER 57  53  53  SER SER A . n 
A 1 58  LEU 58  54  54  LEU LEU A . n 
A 1 59  LEU 59  55  55  LEU LEU A . n 
A 1 60  LYS 60  56  56  LYS LYS A . n 
A 1 61  GLU 61  57  57  GLU GLU A . n 
A 1 62  LEU 62  58  58  LEU LEU A . n 
A 1 63  ASN 63  59  59  ASN ASN A . n 
A 1 64  HIS 64  60  60  HIS HIS A . n 
A 1 65  PRO 65  61  61  PRO PRO A . n 
A 1 66  ASN 66  62  62  ASN ASN A . n 
A 1 67  ILE 67  63  63  ILE ILE A . n 
A 1 68  VAL 68  64  64  VAL VAL A . n 
A 1 69  LYS 69  65  65  LYS LYS A . n 
A 1 70  LEU 70  66  66  LEU LEU A . n 
A 1 71  LEU 71  67  67  LEU LEU A . n 
A 1 72  ASP 72  68  68  ASP ASP A . n 
A 1 73  VAL 73  69  69  VAL VAL A . n 
A 1 74  ILE 74  70  70  ILE ILE A . n 
A 1 75  HIS 75  71  71  HIS HIS A . n 
A 1 76  THR 76  72  72  THR THR A . n 
A 1 77  GLU 77  73  73  GLU GLU A . n 
A 1 78  ASN 78  74  74  ASN ASN A . n 
A 1 79  LYS 79  75  75  LYS LYS A . n 
A 1 80  LEU 80  76  76  LEU LEU A . n 
A 1 81  TYR 81  77  77  TYR TYR A . n 
A 1 82  LEU 82  78  78  LEU LEU A . n 
A 1 83  VAL 83  79  79  VAL VAL A . n 
A 1 84  PHE 84  80  80  PHE PHE A . n 
A 1 85  GLU 85  81  81  GLU GLU A . n 
A 1 86  PHE 86  82  82  PHE PHE A . n 
A 1 87  LEU 87  83  83  LEU LEU A . n 
A 1 88  HIS 88  84  84  HIS HIS A . n 
A 1 89  GLN 89  85  85  GLN GLN A . n 
A 1 90  ASP 90  86  86  ASP ASP A . n 
A 1 91  LEU 91  87  87  LEU LEU A . n 
A 1 92  LYS 92  88  88  LYS LYS A . n 
A 1 93  LYS 93  89  89  LYS LYS A . n 
A 1 94  PHE 94  90  90  PHE PHE A . n 
A 1 95  MET 95  91  91  MET MET A . n 
A 1 96  ASP 96  92  92  ASP ASP A . n 
A 1 97  ALA 97  93  93  ALA ALA A . n 
A 1 98  SER 98  94  94  SER SER A . n 
A 1 99  ALA 99  95  95  ALA ALA A . n 
A 1 100 LEU 100 96  96  LEU LEU A . n 
A 1 101 THR 101 97  97  THR THR A . n 
A 1 102 GLY 102 98  98  GLY GLY A . n 
A 1 103 ILE 103 99  99  ILE ILE A . n 
A 1 104 PRO 104 100 100 PRO PRO A . n 
A 1 105 LEU 105 101 101 LEU LEU A . n 
A 1 106 PRO 106 102 102 PRO PRO A . n 
A 1 107 LEU 107 103 103 LEU LEU A . n 
A 1 108 ILE 108 104 104 ILE ILE A . n 
A 1 109 LYS 109 105 105 LYS LYS A . n 
A 1 110 SER 110 106 106 SER SER A . n 
A 1 111 TYR 111 107 107 TYR TYR A . n 
A 1 112 LEU 112 108 108 LEU LEU A . n 
A 1 113 PHE 113 109 109 PHE PHE A . n 
A 1 114 GLN 114 110 110 GLN GLN A . n 
A 1 115 LEU 115 111 111 LEU LEU A . n 
A 1 116 LEU 116 112 112 LEU LEU A . n 
A 1 117 GLN 117 113 113 GLN GLN A . n 
A 1 118 GLY 118 114 114 GLY GLY A . n 
A 1 119 LEU 119 115 115 LEU LEU A . n 
A 1 120 ALA 120 116 116 ALA ALA A . n 
A 1 121 PHE 121 117 117 PHE PHE A . n 
A 1 122 CYS 122 118 118 CYS CYS A . n 
A 1 123 HIS 123 119 119 HIS HIS A . n 
A 1 124 SER 124 120 120 SER SER A . n 
A 1 125 HIS 125 121 121 HIS HIS A . n 
A 1 126 ARG 126 122 122 ARG ARG A . n 
A 1 127 VAL 127 123 123 VAL VAL A . n 
A 1 128 LEU 128 124 124 LEU LEU A . n 
A 1 129 HIS 129 125 125 HIS HIS A . n 
A 1 130 ARG 130 126 126 ARG ARG A . n 
A 1 131 ASP 131 127 127 ASP ASP A . n 
A 1 132 LEU 132 128 128 LEU LEU A . n 
A 1 133 LYS 133 129 129 LYS LYS A . n 
A 1 134 PRO 134 130 130 PRO PRO A . n 
A 1 135 GLN 135 131 131 GLN GLN A . n 
A 1 136 ASN 136 132 132 ASN ASN A . n 
A 1 137 LEU 137 133 133 LEU LEU A . n 
A 1 138 LEU 138 134 134 LEU LEU A . n 
A 1 139 ILE 139 135 135 ILE ILE A . n 
A 1 140 ASN 140 136 136 ASN ASN A . n 
A 1 141 THR 141 137 137 THR THR A . n 
A 1 142 GLU 142 138 138 GLU GLU A . n 
A 1 143 GLY 143 139 139 GLY GLY A . n 
A 1 144 ALA 144 140 140 ALA ALA A . n 
A 1 145 ILE 145 141 141 ILE ILE A . n 
A 1 146 LYS 146 142 142 LYS LYS A . n 
A 1 147 LEU 147 143 143 LEU LEU A . n 
A 1 148 ALA 148 144 144 ALA ALA A . n 
A 1 149 ASP 149 145 145 ASP ASP A . n 
A 1 150 PHE 150 146 146 PHE PHE A . n 
A 1 151 GLY 151 147 147 GLY GLY A . n 
A 1 152 LEU 152 148 148 LEU LEU A . n 
A 1 153 ALA 153 149 149 ALA ALA A . n 
A 1 154 ARG 154 150 150 ARG ARG A . n 
A 1 155 ALA 155 151 151 ALA ALA A . n 
A 1 156 PHE 156 152 152 PHE PHE A . n 
A 1 157 GLY 157 153 153 GLY GLY A . n 
A 1 158 VAL 158 154 154 VAL VAL A . n 
A 1 159 PRO 159 155 155 PRO PRO A . n 
A 1 160 VAL 160 156 156 VAL VAL A . n 
A 1 161 ARG 161 157 157 ARG ARG A . n 
A 1 162 THR 162 158 158 THR THR A . n 
A 1 163 TYR 163 159 159 TYR TYR A . n 
A 1 164 TPO 164 160 160 TPO TPO A . n 
A 1 165 HIS 165 161 161 HIS HIS A . n 
A 1 166 GLU 166 162 162 GLU GLU A . n 
A 1 167 VAL 167 163 163 VAL VAL A . n 
A 1 168 VAL 168 164 164 VAL VAL A . n 
A 1 169 THR 169 165 165 THR THR A . n 
A 1 170 LEU 170 166 166 LEU LEU A . n 
A 1 171 TRP 171 167 167 TRP TRP A . n 
A 1 172 TYR 172 168 168 TYR TYR A . n 
A 1 173 ARG 173 169 169 ARG ARG A . n 
A 1 174 ALA 174 170 170 ALA ALA A . n 
A 1 175 PRO 175 171 171 PRO PRO A . n 
A 1 176 GLU 176 172 172 GLU GLU A . n 
A 1 177 ILE 177 173 173 ILE ILE A . n 
A 1 178 LEU 178 174 174 LEU LEU A . n 
A 1 179 LEU 179 175 175 LEU LEU A . n 
A 1 180 GLY 180 176 176 GLY GLY A . n 
A 1 181 CYS 181 177 177 CYS CYS A . n 
A 1 182 LYS 182 178 178 LYS LYS A . n 
A 1 183 TYR 183 179 179 TYR TYR A . n 
A 1 184 TYR 184 180 180 TYR TYR A . n 
A 1 185 SER 185 181 181 SER SER A . n 
A 1 186 THR 186 182 182 THR THR A . n 
A 1 187 ALA 187 183 183 ALA ALA A . n 
A 1 188 VAL 188 184 184 VAL VAL A . n 
A 1 189 ASP 189 185 185 ASP ASP A . n 
A 1 190 ILE 190 186 186 ILE ILE A . n 
A 1 191 TRP 191 187 187 TRP TRP A . n 
A 1 192 SER 192 188 188 SER SER A . n 
A 1 193 LEU 193 189 189 LEU LEU A . n 
A 1 194 GLY 194 190 190 GLY GLY A . n 
A 1 195 CYS 195 191 191 CYS CYS A . n 
A 1 196 ILE 196 192 192 ILE ILE A . n 
A 1 197 PHE 197 193 193 PHE PHE A . n 
A 1 198 ALA 198 194 194 ALA ALA A . n 
A 1 199 GLU 199 195 195 GLU GLU A . n 
A 1 200 MET 200 196 196 MET MET A . n 
A 1 201 VAL 201 197 197 VAL VAL A . n 
A 1 202 THR 202 198 198 THR THR A . n 
A 1 203 ARG 203 199 199 ARG ARG A . n 
A 1 204 ARG 204 200 200 ARG ARG A . n 
A 1 205 ALA 205 201 201 ALA ALA A . n 
A 1 206 LEU 206 202 202 LEU LEU A . n 
A 1 207 PHE 207 203 203 PHE PHE A . n 
A 1 208 PRO 208 204 204 PRO PRO A . n 
A 1 209 GLY 209 205 205 GLY GLY A . n 
A 1 210 ASP 210 206 206 ASP ASP A . n 
A 1 211 SER 211 207 207 SER SER A . n 
A 1 212 GLU 212 208 208 GLU GLU A . n 
A 1 213 ILE 213 209 209 ILE ILE A . n 
A 1 214 ASP 214 210 210 ASP ASP A . n 
A 1 215 GLN 215 211 211 GLN GLN A . n 
A 1 216 LEU 216 212 212 LEU LEU A . n 
A 1 217 PHE 217 213 213 PHE PHE A . n 
A 1 218 ARG 218 214 214 ARG ARG A . n 
A 1 219 ILE 219 215 215 ILE ILE A . n 
A 1 220 PHE 220 216 216 PHE PHE A . n 
A 1 221 ARG 221 217 217 ARG ARG A . n 
A 1 222 THR 222 218 218 THR THR A . n 
A 1 223 LEU 223 219 219 LEU LEU A . n 
A 1 224 GLY 224 220 220 GLY GLY A . n 
A 1 225 THR 225 221 221 THR THR A . n 
A 1 226 PRO 226 222 222 PRO PRO A . n 
A 1 227 ASP 227 223 223 ASP ASP A . n 
A 1 228 GLU 228 224 224 GLU GLU A . n 
A 1 229 VAL 229 225 225 VAL VAL A . n 
A 1 230 VAL 230 226 226 VAL VAL A . n 
A 1 231 TRP 231 227 227 TRP TRP A . n 
A 1 232 PRO 232 228 228 PRO PRO A . n 
A 1 233 GLY 233 229 229 GLY GLY A . n 
A 1 234 VAL 234 230 230 VAL VAL A . n 
A 1 235 THR 235 231 231 THR THR A . n 
A 1 236 SER 236 232 232 SER SER A . n 
A 1 237 MET 237 233 233 MET MET A . n 
A 1 238 PRO 238 234 234 PRO PRO A . n 
A 1 239 ASP 239 235 235 ASP ASP A . n 
A 1 240 TYR 240 236 236 TYR TYR A . n 
A 1 241 LYS 241 237 237 LYS LYS A . n 
A 1 242 PRO 242 238 238 PRO PRO A . n 
A 1 243 SER 243 239 239 SER SER A . n 
A 1 244 PHE 244 240 240 PHE PHE A . n 
A 1 245 PRO 245 241 241 PRO PRO A . n 
A 1 246 LYS 246 242 242 LYS LYS A . n 
A 1 247 TRP 247 243 243 TRP TRP A . n 
A 1 248 ALA 248 244 244 ALA ALA A . n 
A 1 249 ARG 249 245 245 ARG ARG A . n 
A 1 250 GLN 250 246 246 GLN GLN A . n 
A 1 251 ASP 251 247 247 ASP ASP A . n 
A 1 252 PHE 252 248 248 PHE PHE A . n 
A 1 253 SER 253 249 249 SER SER A . n 
A 1 254 LYS 254 250 250 LYS LYS A . n 
A 1 255 VAL 255 251 251 VAL VAL A . n 
A 1 256 VAL 256 252 252 VAL VAL A . n 
A 1 257 PRO 257 253 253 PRO PRO A . n 
A 1 258 PRO 258 254 254 PRO PRO A . n 
A 1 259 LEU 259 255 255 LEU LEU A . n 
A 1 260 ASP 260 256 256 ASP ASP A . n 
A 1 261 GLU 261 257 257 GLU GLU A . n 
A 1 262 ASP 262 258 258 ASP ASP A . n 
A 1 263 GLY 263 259 259 GLY GLY A . n 
A 1 264 ARG 264 260 260 ARG ARG A . n 
A 1 265 SER 265 261 261 SER SER A . n 
A 1 266 LEU 266 262 262 LEU LEU A . n 
A 1 267 LEU 267 263 263 LEU LEU A . n 
A 1 268 SER 268 264 264 SER SER A . n 
A 1 269 GLN 269 265 265 GLN GLN A . n 
A 1 270 MET 270 266 266 MET MET A . n 
A 1 271 LEU 271 267 267 LEU LEU A . n 
A 1 272 HIS 272 268 268 HIS HIS A . n 
A 1 273 TYR 273 269 269 TYR TYR A . n 
A 1 274 ASP 274 270 270 ASP ASP A . n 
A 1 275 PRO 275 271 271 PRO PRO A . n 
A 1 276 ASN 276 272 272 ASN ASN A . n 
A 1 277 LYS 277 273 273 LYS LYS A . n 
A 1 278 ARG 278 274 274 ARG ARG A . n 
A 1 279 ILE 279 275 275 ILE ILE A . n 
A 1 280 SER 280 276 276 SER SER A . n 
A 1 281 ALA 281 277 277 ALA ALA A . n 
A 1 282 LYS 282 278 278 LYS LYS A . n 
A 1 283 ALA 283 279 279 ALA ALA A . n 
A 1 284 ALA 284 280 280 ALA ALA A . n 
A 1 285 LEU 285 281 281 LEU LEU A . n 
A 1 286 ALA 286 282 282 ALA ALA A . n 
A 1 287 HIS 287 283 283 HIS HIS A . n 
A 1 288 PRO 288 284 284 PRO PRO A . n 
A 1 289 PHE 289 285 285 PHE PHE A . n 
A 1 290 PHE 290 286 286 PHE PHE A . n 
A 1 291 GLN 291 287 287 GLN GLN A . n 
A 1 292 ASP 292 288 288 ASP ASP A . n 
A 1 293 VAL 293 289 289 VAL VAL A . n 
A 1 294 THR 294 290 290 THR THR A . n 
A 1 295 LYS 295 291 291 LYS LYS A . n 
A 1 296 PRO 296 292 292 PRO PRO A . n 
A 1 297 VAL 297 293 293 VAL VAL A . n 
A 1 298 PRO 298 294 294 PRO PRO A . n 
A 1 299 HIS 299 295 295 HIS HIS A . n 
A 1 300 LEU 300 296 296 LEU LEU A . n 
A 1 301 ARG 301 297 297 ARG ARG A . n 
A 1 302 LEU 302 298 298 LEU LEU A . n 
B 2 1   GLY 1   171 171 GLY GLY B . n 
B 2 2   VAL 2   172 172 VAL VAL B . n 
B 2 3   ASN 3   173 173 ASN ASN B . n 
B 2 4   GLU 4   174 174 GLU GLU B . n 
B 2 5   VAL 5   175 175 VAL VAL B . n 
B 2 6   PRO 6   176 176 PRO PRO B . n 
B 2 7   ASP 7   177 177 ASP ASP B . n 
B 2 8   TYR 8   178 178 TYR TYR B . n 
B 2 9   HIS 9   179 179 HIS HIS B . n 
B 2 10  GLU 10  180 180 GLU GLU B . n 
B 2 11  ASP 11  181 181 ASP ASP B . n 
B 2 12  ILE 12  182 182 ILE ILE B . n 
B 2 13  HIS 13  183 183 HIS HIS B . n 
B 2 14  THR 14  184 184 THR THR B . n 
B 2 15  TYR 15  185 185 TYR TYR B . n 
B 2 16  LEU 16  186 186 LEU LEU B . n 
B 2 17  ARG 17  187 187 ARG ARG B . n 
B 2 18  GLU 18  188 188 GLU GLU B . n 
B 2 19  MET 19  189 189 MET MET B . n 
B 2 20  GLU 20  190 190 GLU GLU B . n 
B 2 21  VAL 21  191 191 VAL VAL B . n 
B 2 22  LYS 22  192 192 LYS LYS B . n 
B 2 23  CYS 23  193 193 CYS CYS B . n 
B 2 24  LYS 24  194 194 LYS LYS B . n 
B 2 25  PRO 25  195 195 PRO PRO B . n 
B 2 26  LYS 26  196 196 LYS LYS B . n 
B 2 27  VAL 27  197 197 VAL VAL B . n 
B 2 28  GLY 28  198 198 GLY GLY B . n 
B 2 29  TYR 29  199 199 TYR TYR B . n 
B 2 30  MET 30  200 200 MET MET B . n 
B 2 31  LYS 31  201 201 LYS LYS B . n 
B 2 32  LYS 32  202 202 LYS LYS B . n 
B 2 33  GLN 33  203 203 GLN GLN B . n 
B 2 34  PRO 34  204 204 PRO PRO B . n 
B 2 35  ASP 35  205 205 ASP ASP B . n 
B 2 36  ILE 36  206 206 ILE ILE B . n 
B 2 37  THR 37  207 207 THR THR B . n 
B 2 38  ASN 38  208 208 ASN ASN B . n 
B 2 39  SER 39  209 209 SER SER B . n 
B 2 40  MET 40  210 210 MET MET B . n 
B 2 41  ARG 41  211 211 ARG ARG B . n 
B 2 42  ALA 42  212 212 ALA ALA B . n 
B 2 43  ILE 43  213 213 ILE ILE B . n 
B 2 44  LEU 44  214 214 LEU LEU B . n 
B 2 45  VAL 45  215 215 VAL VAL B . n 
B 2 46  ASP 46  216 216 ASP ASP B . n 
B 2 47  TRP 47  217 217 TRP TRP B . n 
B 2 48  LEU 48  218 218 LEU LEU B . n 
B 2 49  VAL 49  219 219 VAL VAL B . n 
B 2 50  GLU 50  220 220 GLU GLU B . n 
B 2 51  VAL 51  221 221 VAL VAL B . n 
B 2 52  GLY 52  222 222 GLY GLY B . n 
B 2 53  GLU 53  223 223 GLU GLU B . n 
B 2 54  GLU 54  224 224 GLU GLU B . n 
B 2 55  TYR 55  225 225 TYR TYR B . n 
B 2 56  LYS 56  226 226 LYS LYS B . n 
B 2 57  LEU 57  227 227 LEU LEU B . n 
B 2 58  GLN 58  228 228 GLN GLN B . n 
B 2 59  ASN 59  229 229 ASN ASN B . n 
B 2 60  GLU 60  230 230 GLU GLU B . n 
B 2 61  THR 61  231 231 THR THR B . n 
B 2 62  LEU 62  232 232 LEU LEU B . n 
B 2 63  HIS 63  233 233 HIS HIS B . n 
B 2 64  LEU 64  234 234 LEU LEU B . n 
B 2 65  ALA 65  235 235 ALA ALA B . n 
B 2 66  VAL 66  236 236 VAL VAL B . n 
B 2 67  ASN 67  237 237 ASN ASN B . n 
B 2 68  TYR 68  238 238 TYR TYR B . n 
B 2 69  ILE 69  239 239 ILE ILE B . n 
B 2 70  ASP 70  240 240 ASP ASP B . n 
B 2 71  ARG 71  241 241 ARG ARG B . n 
B 2 72  PHE 72  242 242 PHE PHE B . n 
B 2 73  LEU 73  243 243 LEU LEU B . n 
B 2 74  SER 74  244 244 SER SER B . n 
B 2 75  SER 75  245 245 SER SER B . n 
B 2 76  MET 76  246 246 MET MET B . n 
B 2 77  SER 77  247 247 SER SER B . n 
B 2 78  VAL 78  248 248 VAL VAL B . n 
B 2 79  LEU 79  249 249 LEU LEU B . n 
B 2 80  ARG 80  250 250 ARG ARG B . n 
B 2 81  GLY 81  251 251 GLY GLY B . n 
B 2 82  LYS 82  252 252 LYS LYS B . n 
B 2 83  LEU 83  253 253 LEU LEU B . n 
B 2 84  GLN 84  254 254 GLN GLN B . n 
B 2 85  LEU 85  255 255 LEU LEU B . n 
B 2 86  VAL 86  256 256 VAL VAL B . n 
B 2 87  GLY 87  257 257 GLY GLY B . n 
B 2 88  THR 88  258 258 THR THR B . n 
B 2 89  ALA 89  259 259 ALA ALA B . n 
B 2 90  ALA 90  260 260 ALA ALA B . n 
B 2 91  MET 91  261 261 MET MET B . n 
B 2 92  LEU 92  262 262 LEU LEU B . n 
B 2 93  LEU 93  263 263 LEU LEU B . n 
B 2 94  ALA 94  264 264 ALA ALA B . n 
B 2 95  SER 95  265 265 SER SER B . n 
B 2 96  LYS 96  266 266 LYS LYS B . n 
B 2 97  PHE 97  267 267 PHE PHE B . n 
B 2 98  GLU 98  268 268 GLU GLU B . n 
B 2 99  GLU 99  269 269 GLU GLU B . n 
B 2 100 ILE 100 270 270 ILE ILE B . n 
B 2 101 TYR 101 271 271 TYR TYR B . n 
B 2 102 PRO 102 272 272 PRO PRO B . n 
B 2 103 PRO 103 273 273 PRO PRO B . n 
B 2 104 GLU 104 274 274 GLU GLU B . n 
B 2 105 VAL 105 275 275 VAL VAL B . n 
B 2 106 ALA 106 276 276 ALA ALA B . n 
B 2 107 GLU 107 277 277 GLU GLU B . n 
B 2 108 PHE 108 278 278 PHE PHE B . n 
B 2 109 VAL 109 279 279 VAL VAL B . n 
B 2 110 TYR 110 280 280 TYR TYR B . n 
B 2 111 ILE 111 281 281 ILE ILE B . n 
B 2 112 THR 112 282 282 THR THR B . n 
B 2 113 ASP 113 283 283 ASP ASP B . n 
B 2 114 ASP 114 284 284 ASP ASP B . n 
B 2 115 THR 115 285 285 THR THR B . n 
B 2 116 TYR 116 286 286 TYR TYR B . n 
B 2 117 THR 117 287 287 THR THR B . n 
B 2 118 LYS 118 288 288 LYS LYS B . n 
B 2 119 LYS 119 289 289 LYS LYS B . n 
B 2 120 GLN 120 290 290 GLN GLN B . n 
B 2 121 VAL 121 291 291 VAL VAL B . n 
B 2 122 LEU 122 292 292 LEU LEU B . n 
B 2 123 ARG 123 293 293 ARG ARG B . n 
B 2 124 MET 124 294 294 MET MET B . n 
B 2 125 GLU 125 295 295 GLU GLU B . n 
B 2 126 HIS 126 296 296 HIS HIS B . n 
B 2 127 LEU 127 297 297 LEU LEU B . n 
B 2 128 VAL 128 298 298 VAL VAL B . n 
B 2 129 LEU 129 299 299 LEU LEU B . n 
B 2 130 LYS 130 300 300 LYS LYS B . n 
B 2 131 VAL 131 301 301 VAL VAL B . n 
B 2 132 LEU 132 302 302 LEU LEU B . n 
B 2 133 ALA 133 303 303 ALA ALA B . n 
B 2 134 PHE 134 304 304 PHE PHE B . n 
B 2 135 ASP 135 305 305 ASP ASP B . n 
B 2 136 LEU 136 306 306 LEU LEU B . n 
B 2 137 ALA 137 307 307 ALA ALA B . n 
B 2 138 ALA 138 308 308 ALA ALA B . n 
B 2 139 PRO 139 309 309 PRO PRO B . n 
B 2 140 THR 140 310 310 THR THR B . n 
B 2 141 ILE 141 311 311 ILE ILE B . n 
B 2 142 ASN 142 312 312 ASN ASN B . n 
B 2 143 GLN 143 313 313 GLN GLN B . n 
B 2 144 PHE 144 314 314 PHE PHE B . n 
B 2 145 LEU 145 315 315 LEU LEU B . n 
B 2 146 THR 146 316 316 THR THR B . n 
B 2 147 GLN 147 317 317 GLN GLN B . n 
B 2 148 TYR 148 318 318 TYR TYR B . n 
B 2 149 PHE 149 319 319 PHE PHE B . n 
B 2 150 LEU 150 320 320 LEU LEU B . n 
B 2 151 HIS 151 321 321 HIS HIS B . n 
B 2 152 GLN 152 322 322 GLN GLN B . n 
B 2 153 GLN 153 323 323 GLN GLN B . n 
B 2 154 PRO 154 324 324 PRO PRO B . n 
B 2 155 ALA 155 325 325 ALA ALA B . n 
B 2 156 ASN 156 326 326 ASN ASN B . n 
B 2 157 CYS 157 327 327 CYS CYS B . n 
B 2 158 LYS 158 328 328 LYS LYS B . n 
B 2 159 VAL 159 329 329 VAL VAL B . n 
B 2 160 GLU 160 330 330 GLU GLU B . n 
B 2 161 SER 161 331 331 SER SER B . n 
B 2 162 LEU 162 332 332 LEU LEU B . n 
B 2 163 ALA 163 333 333 ALA ALA B . n 
B 2 164 MET 164 334 334 MET MET B . n 
B 2 165 PHE 165 335 335 PHE PHE B . n 
B 2 166 LEU 166 336 336 LEU LEU B . n 
B 2 167 GLY 167 337 337 GLY GLY B . n 
B 2 168 GLU 168 338 338 GLU GLU B . n 
B 2 169 LEU 169 339 339 LEU LEU B . n 
B 2 170 SER 170 340 340 SER SER B . n 
B 2 171 LEU 171 341 341 LEU LEU B . n 
B 2 172 ILE 172 342 342 ILE ILE B . n 
B 2 173 ASP 173 343 343 ASP ASP B . n 
B 2 174 ALA 174 344 344 ALA ALA B . n 
B 2 175 ASP 175 345 345 ASP ASP B . n 
B 2 176 PRO 176 346 346 PRO PRO B . n 
B 2 177 TYR 177 347 347 TYR TYR B . n 
B 2 178 LEU 178 348 348 LEU LEU B . n 
B 2 179 LYS 179 349 349 LYS LYS B . n 
B 2 180 TYR 180 350 350 TYR TYR B . n 
B 2 181 LEU 181 351 351 LEU LEU B . n 
B 2 182 PRO 182 352 352 PRO PRO B . n 
B 2 183 SER 183 353 353 SER SER B . n 
B 2 184 VAL 184 354 354 VAL VAL B . n 
B 2 185 ILE 185 355 355 ILE ILE B . n 
B 2 186 ALA 186 356 356 ALA ALA B . n 
B 2 187 ALA 187 357 357 ALA ALA B . n 
B 2 188 ALA 188 358 358 ALA ALA B . n 
B 2 189 ALA 189 359 359 ALA ALA B . n 
B 2 190 PHE 190 360 360 PHE PHE B . n 
B 2 191 HIS 191 361 361 HIS HIS B . n 
B 2 192 LEU 192 362 362 LEU LEU B . n 
B 2 193 ALA 193 363 363 ALA ALA B . n 
B 2 194 LEU 194 364 364 LEU LEU B . n 
B 2 195 TYR 195 365 365 TYR TYR B . n 
B 2 196 THR 196 366 366 THR THR B . n 
B 2 197 VAL 197 367 367 VAL VAL B . n 
B 2 198 THR 198 368 368 THR THR B . n 
B 2 199 GLY 199 369 369 GLY GLY B . n 
B 2 200 GLN 200 370 370 GLN GLN B . n 
B 2 201 SER 201 371 371 SER SER B . n 
B 2 202 TRP 202 372 372 TRP TRP B . n 
B 2 203 PRO 203 373 373 PRO PRO B . n 
B 2 204 GLU 204 374 374 GLU GLU B . n 
B 2 205 SER 205 375 375 SER SER B . n 
B 2 206 LEU 206 376 376 LEU LEU B . n 
B 2 207 VAL 207 377 377 VAL VAL B . n 
B 2 208 GLN 208 378 378 GLN GLN B . n 
B 2 209 LYS 209 379 379 LYS LYS B . n 
B 2 210 THR 210 380 380 THR THR B . n 
B 2 211 GLY 211 381 381 GLY GLY B . n 
B 2 212 TYR 212 382 382 TYR TYR B . n 
B 2 213 THR 213 383 383 THR THR B . n 
B 2 214 LEU 214 384 384 LEU LEU B . n 
B 2 215 GLU 215 385 385 GLU GLU B . n 
B 2 216 THR 216 386 386 THR THR B . n 
B 2 217 LEU 217 387 387 LEU LEU B . n 
B 2 218 LYS 218 388 388 LYS LYS B . n 
B 2 219 PRO 219 389 389 PRO PRO B . n 
B 2 220 CYS 220 390 390 CYS CYS B . n 
B 2 221 LEU 221 391 391 LEU LEU B . n 
B 2 222 LEU 222 392 392 LEU LEU B . n 
B 2 223 ASP 223 393 393 ASP ASP B . n 
B 2 224 LEU 224 394 394 LEU LEU B . n 
B 2 225 HIS 225 395 395 HIS HIS B . n 
B 2 226 GLN 226 396 396 GLN GLN B . n 
B 2 227 THR 227 397 397 THR THR B . n 
B 2 228 TYR 228 398 398 TYR TYR B . n 
B 2 229 LEU 229 399 399 LEU LEU B . n 
B 2 230 ARG 230 400 400 ARG ARG B . n 
B 2 231 ALA 231 401 401 ALA ALA B . n 
B 2 232 PRO 232 402 402 PRO PRO B . n 
B 2 233 GLN 233 403 403 GLN GLN B . n 
B 2 234 HIS 234 404 404 HIS HIS B . n 
B 2 235 ALA 235 405 405 ALA ALA B . n 
B 2 236 GLN 236 406 406 GLN GLN B . n 
B 2 237 GLN 237 407 407 GLN GLN B . n 
B 2 238 SER 238 408 408 SER SER B . n 
B 2 239 ILE 239 409 409 ILE ILE B . n 
B 2 240 ARG 240 410 410 ARG ARG B . n 
B 2 241 GLU 241 411 411 GLU GLU B . n 
B 2 242 LYS 242 412 412 LYS LYS B . n 
B 2 243 TYR 243 413 413 TYR TYR B . n 
B 2 244 LYS 244 414 414 LYS LYS B . n 
B 2 245 ASN 245 415 415 ASN ASN B . n 
B 2 246 SER 246 416 416 SER SER B . n 
B 2 247 LYS 247 417 417 LYS LYS B . n 
B 2 248 TYR 248 418 418 TYR TYR B . n 
B 2 249 HIS 249 419 419 HIS HIS B . n 
B 2 250 GLY 250 420 420 GLY GLY B . n 
B 2 251 VAL 251 421 421 VAL VAL B . n 
B 2 252 SER 252 422 422 SER SER B . n 
B 2 253 LEU 253 423 423 LEU LEU B . n 
B 2 254 LEU 254 424 424 LEU LEU B . n 
B 2 255 ASN 255 425 425 ASN ASN B . n 
B 2 256 PRO 256 426 426 PRO PRO B . n 
B 2 257 PRO 257 427 427 PRO PRO B . n 
B 2 258 GLU 258 428 428 GLU GLU B . n 
B 2 259 THR 259 429 429 THR THR B . n 
B 2 260 LEU 260 430 430 LEU LEU B . n 
B 2 261 ASN 261 431 431 ASN ASN B . n 
B 2 262 VAL 262 432 432 VAL VAL B . n 
B 2 263 HIS 263 433 ?   ?   ?   B . n 
B 2 264 HIS 264 434 ?   ?   ?   B . n 
B 2 265 HIS 265 435 ?   ?   ?   B . n 
B 2 266 HIS 266 436 ?   ?   ?   B . n 
B 2 267 HIS 267 437 ?   ?   ?   B . n 
B 2 268 HIS 268 438 ?   ?   ?   B . n 
C 1 1   GLY 1   -3  ?   ?   ?   C . n 
C 1 2   PRO 2   -2  ?   ?   ?   C . n 
C 1 3   GLY 3   -1  -1  GLY GLY C . n 
C 1 4   SER 4   0   0   SER SER C . n 
C 1 5   MET 5   1   1   MET MET C . n 
C 1 6   GLU 6   2   2   GLU GLU C . n 
C 1 7   ASN 7   3   3   ASN ASN C . n 
C 1 8   PHE 8   4   4   PHE PHE C . n 
C 1 9   GLN 9   5   5   GLN GLN C . n 
C 1 10  LYS 10  6   6   LYS LYS C . n 
C 1 11  VAL 11  7   7   VAL VAL C . n 
C 1 12  GLU 12  8   8   GLU GLU C . n 
C 1 13  LYS 13  9   9   LYS LYS C . n 
C 1 14  ILE 14  10  10  ILE ILE C . n 
C 1 15  GLY 15  11  11  GLY GLY C . n 
C 1 16  GLU 16  12  12  GLU GLU C . n 
C 1 17  GLY 17  13  13  GLY GLY C . n 
C 1 18  THR 18  14  14  THR THR C . n 
C 1 19  TYR 19  15  15  TYR TYR C . n 
C 1 20  GLY 20  16  16  GLY GLY C . n 
C 1 21  VAL 21  17  17  VAL VAL C . n 
C 1 22  VAL 22  18  18  VAL VAL C . n 
C 1 23  TYR 23  19  19  TYR TYR C . n 
C 1 24  LYS 24  20  20  LYS LYS C . n 
C 1 25  ALA 25  21  21  ALA ALA C . n 
C 1 26  ARG 26  22  22  ARG ARG C . n 
C 1 27  ASN 27  23  23  ASN ASN C . n 
C 1 28  LYS 28  24  24  LYS LYS C . n 
C 1 29  LEU 29  25  25  LEU LEU C . n 
C 1 30  THR 30  26  26  THR THR C . n 
C 1 31  GLY 31  27  27  GLY GLY C . n 
C 1 32  GLU 32  28  28  GLU GLU C . n 
C 1 33  VAL 33  29  29  VAL VAL C . n 
C 1 34  VAL 34  30  30  VAL VAL C . n 
C 1 35  ALA 35  31  31  ALA ALA C . n 
C 1 36  LEU 36  32  32  LEU LEU C . n 
C 1 37  LYS 37  33  33  LYS LYS C . n 
C 1 38  LYS 38  34  34  LYS LYS C . n 
C 1 39  ILE 39  35  35  ILE ILE C . n 
C 1 40  ARG 40  36  36  ARG ARG C . n 
C 1 41  LEU 41  37  37  LEU LEU C . n 
C 1 42  ASP 42  38  38  ASP ASP C . n 
C 1 43  THR 43  39  39  THR THR C . n 
C 1 44  GLU 44  40  40  GLU GLU C . n 
C 1 45  THR 45  41  41  THR THR C . n 
C 1 46  GLU 46  42  42  GLU GLU C . n 
C 1 47  GLY 47  43  43  GLY GLY C . n 
C 1 48  VAL 48  44  44  VAL VAL C . n 
C 1 49  PRO 49  45  45  PRO PRO C . n 
C 1 50  SER 50  46  46  SER SER C . n 
C 1 51  THR 51  47  47  THR THR C . n 
C 1 52  ALA 52  48  48  ALA ALA C . n 
C 1 53  ILE 53  49  49  ILE ILE C . n 
C 1 54  ARG 54  50  50  ARG ARG C . n 
C 1 55  GLU 55  51  51  GLU GLU C . n 
C 1 56  ILE 56  52  52  ILE ILE C . n 
C 1 57  SER 57  53  53  SER SER C . n 
C 1 58  LEU 58  54  54  LEU LEU C . n 
C 1 59  LEU 59  55  55  LEU LEU C . n 
C 1 60  LYS 60  56  56  LYS LYS C . n 
C 1 61  GLU 61  57  57  GLU GLU C . n 
C 1 62  LEU 62  58  58  LEU LEU C . n 
C 1 63  ASN 63  59  59  ASN ASN C . n 
C 1 64  HIS 64  60  60  HIS HIS C . n 
C 1 65  PRO 65  61  61  PRO PRO C . n 
C 1 66  ASN 66  62  62  ASN ASN C . n 
C 1 67  ILE 67  63  63  ILE ILE C . n 
C 1 68  VAL 68  64  64  VAL VAL C . n 
C 1 69  LYS 69  65  65  LYS LYS C . n 
C 1 70  LEU 70  66  66  LEU LEU C . n 
C 1 71  LEU 71  67  67  LEU LEU C . n 
C 1 72  ASP 72  68  68  ASP ASP C . n 
C 1 73  VAL 73  69  69  VAL VAL C . n 
C 1 74  ILE 74  70  70  ILE ILE C . n 
C 1 75  HIS 75  71  71  HIS HIS C . n 
C 1 76  THR 76  72  72  THR THR C . n 
C 1 77  GLU 77  73  73  GLU GLU C . n 
C 1 78  ASN 78  74  74  ASN ASN C . n 
C 1 79  LYS 79  75  75  LYS LYS C . n 
C 1 80  LEU 80  76  76  LEU LEU C . n 
C 1 81  TYR 81  77  77  TYR TYR C . n 
C 1 82  LEU 82  78  78  LEU LEU C . n 
C 1 83  VAL 83  79  79  VAL VAL C . n 
C 1 84  PHE 84  80  80  PHE PHE C . n 
C 1 85  GLU 85  81  81  GLU GLU C . n 
C 1 86  PHE 86  82  82  PHE PHE C . n 
C 1 87  LEU 87  83  83  LEU LEU C . n 
C 1 88  HIS 88  84  84  HIS HIS C . n 
C 1 89  GLN 89  85  85  GLN GLN C . n 
C 1 90  ASP 90  86  86  ASP ASP C . n 
C 1 91  LEU 91  87  87  LEU LEU C . n 
C 1 92  LYS 92  88  88  LYS LYS C . n 
C 1 93  LYS 93  89  89  LYS LYS C . n 
C 1 94  PHE 94  90  90  PHE PHE C . n 
C 1 95  MET 95  91  91  MET MET C . n 
C 1 96  ASP 96  92  92  ASP ASP C . n 
C 1 97  ALA 97  93  93  ALA ALA C . n 
C 1 98  SER 98  94  94  SER SER C . n 
C 1 99  ALA 99  95  95  ALA ALA C . n 
C 1 100 LEU 100 96  96  LEU LEU C . n 
C 1 101 THR 101 97  97  THR THR C . n 
C 1 102 GLY 102 98  98  GLY GLY C . n 
C 1 103 ILE 103 99  99  ILE ILE C . n 
C 1 104 PRO 104 100 100 PRO PRO C . n 
C 1 105 LEU 105 101 101 LEU LEU C . n 
C 1 106 PRO 106 102 102 PRO PRO C . n 
C 1 107 LEU 107 103 103 LEU LEU C . n 
C 1 108 ILE 108 104 104 ILE ILE C . n 
C 1 109 LYS 109 105 105 LYS LYS C . n 
C 1 110 SER 110 106 106 SER SER C . n 
C 1 111 TYR 111 107 107 TYR TYR C . n 
C 1 112 LEU 112 108 108 LEU LEU C . n 
C 1 113 PHE 113 109 109 PHE PHE C . n 
C 1 114 GLN 114 110 110 GLN GLN C . n 
C 1 115 LEU 115 111 111 LEU LEU C . n 
C 1 116 LEU 116 112 112 LEU LEU C . n 
C 1 117 GLN 117 113 113 GLN GLN C . n 
C 1 118 GLY 118 114 114 GLY GLY C . n 
C 1 119 LEU 119 115 115 LEU LEU C . n 
C 1 120 ALA 120 116 116 ALA ALA C . n 
C 1 121 PHE 121 117 117 PHE PHE C . n 
C 1 122 CYS 122 118 118 CYS CYS C . n 
C 1 123 HIS 123 119 119 HIS HIS C . n 
C 1 124 SER 124 120 120 SER SER C . n 
C 1 125 HIS 125 121 121 HIS HIS C . n 
C 1 126 ARG 126 122 122 ARG ARG C . n 
C 1 127 VAL 127 123 123 VAL VAL C . n 
C 1 128 LEU 128 124 124 LEU LEU C . n 
C 1 129 HIS 129 125 125 HIS HIS C . n 
C 1 130 ARG 130 126 126 ARG ARG C . n 
C 1 131 ASP 131 127 127 ASP ASP C . n 
C 1 132 LEU 132 128 128 LEU LEU C . n 
C 1 133 LYS 133 129 129 LYS LYS C . n 
C 1 134 PRO 134 130 130 PRO PRO C . n 
C 1 135 GLN 135 131 131 GLN GLN C . n 
C 1 136 ASN 136 132 132 ASN ASN C . n 
C 1 137 LEU 137 133 133 LEU LEU C . n 
C 1 138 LEU 138 134 134 LEU LEU C . n 
C 1 139 ILE 139 135 135 ILE ILE C . n 
C 1 140 ASN 140 136 136 ASN ASN C . n 
C 1 141 THR 141 137 137 THR THR C . n 
C 1 142 GLU 142 138 138 GLU GLU C . n 
C 1 143 GLY 143 139 139 GLY GLY C . n 
C 1 144 ALA 144 140 140 ALA ALA C . n 
C 1 145 ILE 145 141 141 ILE ILE C . n 
C 1 146 LYS 146 142 142 LYS LYS C . n 
C 1 147 LEU 147 143 143 LEU LEU C . n 
C 1 148 ALA 148 144 144 ALA ALA C . n 
C 1 149 ASP 149 145 145 ASP ASP C . n 
C 1 150 PHE 150 146 146 PHE PHE C . n 
C 1 151 GLY 151 147 147 GLY GLY C . n 
C 1 152 LEU 152 148 148 LEU LEU C . n 
C 1 153 ALA 153 149 149 ALA ALA C . n 
C 1 154 ARG 154 150 150 ARG ARG C . n 
C 1 155 ALA 155 151 151 ALA ALA C . n 
C 1 156 PHE 156 152 152 PHE PHE C . n 
C 1 157 GLY 157 153 153 GLY GLY C . n 
C 1 158 VAL 158 154 154 VAL VAL C . n 
C 1 159 PRO 159 155 155 PRO PRO C . n 
C 1 160 VAL 160 156 156 VAL VAL C . n 
C 1 161 ARG 161 157 157 ARG ARG C . n 
C 1 162 THR 162 158 158 THR THR C . n 
C 1 163 TYR 163 159 159 TYR TYR C . n 
C 1 164 TPO 164 160 160 TPO TPO C . n 
C 1 165 HIS 165 161 161 HIS HIS C . n 
C 1 166 GLU 166 162 162 GLU GLU C . n 
C 1 167 VAL 167 163 163 VAL VAL C . n 
C 1 168 VAL 168 164 164 VAL VAL C . n 
C 1 169 THR 169 165 165 THR THR C . n 
C 1 170 LEU 170 166 166 LEU LEU C . n 
C 1 171 TRP 171 167 167 TRP TRP C . n 
C 1 172 TYR 172 168 168 TYR TYR C . n 
C 1 173 ARG 173 169 169 ARG ARG C . n 
C 1 174 ALA 174 170 170 ALA ALA C . n 
C 1 175 PRO 175 171 171 PRO PRO C . n 
C 1 176 GLU 176 172 172 GLU GLU C . n 
C 1 177 ILE 177 173 173 ILE ILE C . n 
C 1 178 LEU 178 174 174 LEU LEU C . n 
C 1 179 LEU 179 175 175 LEU LEU C . n 
C 1 180 GLY 180 176 176 GLY GLY C . n 
C 1 181 CYS 181 177 177 CYS CYS C . n 
C 1 182 LYS 182 178 178 LYS LYS C . n 
C 1 183 TYR 183 179 179 TYR TYR C . n 
C 1 184 TYR 184 180 180 TYR TYR C . n 
C 1 185 SER 185 181 181 SER SER C . n 
C 1 186 THR 186 182 182 THR THR C . n 
C 1 187 ALA 187 183 183 ALA ALA C . n 
C 1 188 VAL 188 184 184 VAL VAL C . n 
C 1 189 ASP 189 185 185 ASP ASP C . n 
C 1 190 ILE 190 186 186 ILE ILE C . n 
C 1 191 TRP 191 187 187 TRP TRP C . n 
C 1 192 SER 192 188 188 SER SER C . n 
C 1 193 LEU 193 189 189 LEU LEU C . n 
C 1 194 GLY 194 190 190 GLY GLY C . n 
C 1 195 CYS 195 191 191 CYS CYS C . n 
C 1 196 ILE 196 192 192 ILE ILE C . n 
C 1 197 PHE 197 193 193 PHE PHE C . n 
C 1 198 ALA 198 194 194 ALA ALA C . n 
C 1 199 GLU 199 195 195 GLU GLU C . n 
C 1 200 MET 200 196 196 MET MET C . n 
C 1 201 VAL 201 197 197 VAL VAL C . n 
C 1 202 THR 202 198 198 THR THR C . n 
C 1 203 ARG 203 199 199 ARG ARG C . n 
C 1 204 ARG 204 200 200 ARG ARG C . n 
C 1 205 ALA 205 201 201 ALA ALA C . n 
C 1 206 LEU 206 202 202 LEU LEU C . n 
C 1 207 PHE 207 203 203 PHE PHE C . n 
C 1 208 PRO 208 204 204 PRO PRO C . n 
C 1 209 GLY 209 205 205 GLY GLY C . n 
C 1 210 ASP 210 206 206 ASP ASP C . n 
C 1 211 SER 211 207 207 SER SER C . n 
C 1 212 GLU 212 208 208 GLU GLU C . n 
C 1 213 ILE 213 209 209 ILE ILE C . n 
C 1 214 ASP 214 210 210 ASP ASP C . n 
C 1 215 GLN 215 211 211 GLN GLN C . n 
C 1 216 LEU 216 212 212 LEU LEU C . n 
C 1 217 PHE 217 213 213 PHE PHE C . n 
C 1 218 ARG 218 214 214 ARG ARG C . n 
C 1 219 ILE 219 215 215 ILE ILE C . n 
C 1 220 PHE 220 216 216 PHE PHE C . n 
C 1 221 ARG 221 217 217 ARG ARG C . n 
C 1 222 THR 222 218 218 THR THR C . n 
C 1 223 LEU 223 219 219 LEU LEU C . n 
C 1 224 GLY 224 220 220 GLY GLY C . n 
C 1 225 THR 225 221 221 THR THR C . n 
C 1 226 PRO 226 222 222 PRO PRO C . n 
C 1 227 ASP 227 223 223 ASP ASP C . n 
C 1 228 GLU 228 224 224 GLU GLU C . n 
C 1 229 VAL 229 225 225 VAL VAL C . n 
C 1 230 VAL 230 226 226 VAL VAL C . n 
C 1 231 TRP 231 227 227 TRP TRP C . n 
C 1 232 PRO 232 228 228 PRO PRO C . n 
C 1 233 GLY 233 229 229 GLY GLY C . n 
C 1 234 VAL 234 230 230 VAL VAL C . n 
C 1 235 THR 235 231 231 THR THR C . n 
C 1 236 SER 236 232 232 SER SER C . n 
C 1 237 MET 237 233 233 MET MET C . n 
C 1 238 PRO 238 234 234 PRO PRO C . n 
C 1 239 ASP 239 235 235 ASP ASP C . n 
C 1 240 TYR 240 236 236 TYR TYR C . n 
C 1 241 LYS 241 237 237 LYS LYS C . n 
C 1 242 PRO 242 238 238 PRO PRO C . n 
C 1 243 SER 243 239 239 SER SER C . n 
C 1 244 PHE 244 240 240 PHE PHE C . n 
C 1 245 PRO 245 241 241 PRO PRO C . n 
C 1 246 LYS 246 242 242 LYS LYS C . n 
C 1 247 TRP 247 243 243 TRP TRP C . n 
C 1 248 ALA 248 244 244 ALA ALA C . n 
C 1 249 ARG 249 245 245 ARG ARG C . n 
C 1 250 GLN 250 246 246 GLN GLN C . n 
C 1 251 ASP 251 247 247 ASP ASP C . n 
C 1 252 PHE 252 248 248 PHE PHE C . n 
C 1 253 SER 253 249 249 SER SER C . n 
C 1 254 LYS 254 250 250 LYS LYS C . n 
C 1 255 VAL 255 251 251 VAL VAL C . n 
C 1 256 VAL 256 252 252 VAL VAL C . n 
C 1 257 PRO 257 253 253 PRO PRO C . n 
C 1 258 PRO 258 254 254 PRO PRO C . n 
C 1 259 LEU 259 255 255 LEU LEU C . n 
C 1 260 ASP 260 256 256 ASP ASP C . n 
C 1 261 GLU 261 257 257 GLU GLU C . n 
C 1 262 ASP 262 258 258 ASP ASP C . n 
C 1 263 GLY 263 259 259 GLY GLY C . n 
C 1 264 ARG 264 260 260 ARG ARG C . n 
C 1 265 SER 265 261 261 SER SER C . n 
C 1 266 LEU 266 262 262 LEU LEU C . n 
C 1 267 LEU 267 263 263 LEU LEU C . n 
C 1 268 SER 268 264 264 SER SER C . n 
C 1 269 GLN 269 265 265 GLN GLN C . n 
C 1 270 MET 270 266 266 MET MET C . n 
C 1 271 LEU 271 267 267 LEU LEU C . n 
C 1 272 HIS 272 268 268 HIS HIS C . n 
C 1 273 TYR 273 269 269 TYR TYR C . n 
C 1 274 ASP 274 270 270 ASP ASP C . n 
C 1 275 PRO 275 271 271 PRO PRO C . n 
C 1 276 ASN 276 272 272 ASN ASN C . n 
C 1 277 LYS 277 273 273 LYS LYS C . n 
C 1 278 ARG 278 274 274 ARG ARG C . n 
C 1 279 ILE 279 275 275 ILE ILE C . n 
C 1 280 SER 280 276 276 SER SER C . n 
C 1 281 ALA 281 277 277 ALA ALA C . n 
C 1 282 LYS 282 278 278 LYS LYS C . n 
C 1 283 ALA 283 279 279 ALA ALA C . n 
C 1 284 ALA 284 280 280 ALA ALA C . n 
C 1 285 LEU 285 281 281 LEU LEU C . n 
C 1 286 ALA 286 282 282 ALA ALA C . n 
C 1 287 HIS 287 283 283 HIS HIS C . n 
C 1 288 PRO 288 284 284 PRO PRO C . n 
C 1 289 PHE 289 285 285 PHE PHE C . n 
C 1 290 PHE 290 286 286 PHE PHE C . n 
C 1 291 GLN 291 287 287 GLN GLN C . n 
C 1 292 ASP 292 288 288 ASP ASP C . n 
C 1 293 VAL 293 289 289 VAL VAL C . n 
C 1 294 THR 294 290 290 THR THR C . n 
C 1 295 LYS 295 291 291 LYS LYS C . n 
C 1 296 PRO 296 292 292 PRO PRO C . n 
C 1 297 VAL 297 293 293 VAL VAL C . n 
C 1 298 PRO 298 294 294 PRO PRO C . n 
C 1 299 HIS 299 295 295 HIS HIS C . n 
C 1 300 LEU 300 296 296 LEU LEU C . n 
C 1 301 ARG 301 297 ?   ?   ?   C . n 
C 1 302 LEU 302 298 ?   ?   ?   C . n 
D 2 1   GLY 1   171 171 GLY GLY D . n 
D 2 2   VAL 2   172 172 VAL VAL D . n 
D 2 3   ASN 3   173 173 ASN ASN D . n 
D 2 4   GLU 4   174 174 GLU GLU D . n 
D 2 5   VAL 5   175 175 VAL VAL D . n 
D 2 6   PRO 6   176 176 PRO PRO D . n 
D 2 7   ASP 7   177 177 ASP ASP D . n 
D 2 8   TYR 8   178 178 TYR TYR D . n 
D 2 9   HIS 9   179 179 HIS HIS D . n 
D 2 10  GLU 10  180 180 GLU GLU D . n 
D 2 11  ASP 11  181 181 ASP ASP D . n 
D 2 12  ILE 12  182 182 ILE ILE D . n 
D 2 13  HIS 13  183 183 HIS HIS D . n 
D 2 14  THR 14  184 184 THR THR D . n 
D 2 15  TYR 15  185 185 TYR TYR D . n 
D 2 16  LEU 16  186 186 LEU LEU D . n 
D 2 17  ARG 17  187 187 ARG ARG D . n 
D 2 18  GLU 18  188 188 GLU GLU D . n 
D 2 19  MET 19  189 189 MET MET D . n 
D 2 20  GLU 20  190 190 GLU GLU D . n 
D 2 21  VAL 21  191 191 VAL VAL D . n 
D 2 22  LYS 22  192 192 LYS LYS D . n 
D 2 23  CYS 23  193 193 CYS CYS D . n 
D 2 24  LYS 24  194 194 LYS LYS D . n 
D 2 25  PRO 25  195 195 PRO PRO D . n 
D 2 26  LYS 26  196 196 LYS LYS D . n 
D 2 27  VAL 27  197 197 VAL VAL D . n 
D 2 28  GLY 28  198 198 GLY GLY D . n 
D 2 29  TYR 29  199 199 TYR TYR D . n 
D 2 30  MET 30  200 200 MET MET D . n 
D 2 31  LYS 31  201 201 LYS LYS D . n 
D 2 32  LYS 32  202 202 LYS LYS D . n 
D 2 33  GLN 33  203 203 GLN GLN D . n 
D 2 34  PRO 34  204 204 PRO PRO D . n 
D 2 35  ASP 35  205 205 ASP ASP D . n 
D 2 36  ILE 36  206 206 ILE ILE D . n 
D 2 37  THR 37  207 207 THR THR D . n 
D 2 38  ASN 38  208 208 ASN ASN D . n 
D 2 39  SER 39  209 209 SER SER D . n 
D 2 40  MET 40  210 210 MET MET D . n 
D 2 41  ARG 41  211 211 ARG ARG D . n 
D 2 42  ALA 42  212 212 ALA ALA D . n 
D 2 43  ILE 43  213 213 ILE ILE D . n 
D 2 44  LEU 44  214 214 LEU LEU D . n 
D 2 45  VAL 45  215 215 VAL VAL D . n 
D 2 46  ASP 46  216 216 ASP ASP D . n 
D 2 47  TRP 47  217 217 TRP TRP D . n 
D 2 48  LEU 48  218 218 LEU LEU D . n 
D 2 49  VAL 49  219 219 VAL VAL D . n 
D 2 50  GLU 50  220 220 GLU GLU D . n 
D 2 51  VAL 51  221 221 VAL VAL D . n 
D 2 52  GLY 52  222 222 GLY GLY D . n 
D 2 53  GLU 53  223 223 GLU GLU D . n 
D 2 54  GLU 54  224 224 GLU GLU D . n 
D 2 55  TYR 55  225 225 TYR TYR D . n 
D 2 56  LYS 56  226 226 LYS LYS D . n 
D 2 57  LEU 57  227 227 LEU LEU D . n 
D 2 58  GLN 58  228 228 GLN GLN D . n 
D 2 59  ASN 59  229 229 ASN ASN D . n 
D 2 60  GLU 60  230 230 GLU GLU D . n 
D 2 61  THR 61  231 231 THR THR D . n 
D 2 62  LEU 62  232 232 LEU LEU D . n 
D 2 63  HIS 63  233 233 HIS HIS D . n 
D 2 64  LEU 64  234 234 LEU LEU D . n 
D 2 65  ALA 65  235 235 ALA ALA D . n 
D 2 66  VAL 66  236 236 VAL VAL D . n 
D 2 67  ASN 67  237 237 ASN ASN D . n 
D 2 68  TYR 68  238 238 TYR TYR D . n 
D 2 69  ILE 69  239 239 ILE ILE D . n 
D 2 70  ASP 70  240 240 ASP ASP D . n 
D 2 71  ARG 71  241 241 ARG ARG D . n 
D 2 72  PHE 72  242 242 PHE PHE D . n 
D 2 73  LEU 73  243 243 LEU LEU D . n 
D 2 74  SER 74  244 244 SER SER D . n 
D 2 75  SER 75  245 245 SER SER D . n 
D 2 76  MET 76  246 246 MET MET D . n 
D 2 77  SER 77  247 247 SER SER D . n 
D 2 78  VAL 78  248 248 VAL VAL D . n 
D 2 79  LEU 79  249 249 LEU LEU D . n 
D 2 80  ARG 80  250 250 ARG ARG D . n 
D 2 81  GLY 81  251 251 GLY GLY D . n 
D 2 82  LYS 82  252 252 LYS LYS D . n 
D 2 83  LEU 83  253 253 LEU LEU D . n 
D 2 84  GLN 84  254 254 GLN GLN D . n 
D 2 85  LEU 85  255 255 LEU LEU D . n 
D 2 86  VAL 86  256 256 VAL VAL D . n 
D 2 87  GLY 87  257 257 GLY GLY D . n 
D 2 88  THR 88  258 258 THR THR D . n 
D 2 89  ALA 89  259 259 ALA ALA D . n 
D 2 90  ALA 90  260 260 ALA ALA D . n 
D 2 91  MET 91  261 261 MET MET D . n 
D 2 92  LEU 92  262 262 LEU LEU D . n 
D 2 93  LEU 93  263 263 LEU LEU D . n 
D 2 94  ALA 94  264 264 ALA ALA D . n 
D 2 95  SER 95  265 265 SER SER D . n 
D 2 96  LYS 96  266 266 LYS LYS D . n 
D 2 97  PHE 97  267 267 PHE PHE D . n 
D 2 98  GLU 98  268 268 GLU GLU D . n 
D 2 99  GLU 99  269 269 GLU GLU D . n 
D 2 100 ILE 100 270 270 ILE ILE D . n 
D 2 101 TYR 101 271 271 TYR TYR D . n 
D 2 102 PRO 102 272 272 PRO PRO D . n 
D 2 103 PRO 103 273 273 PRO PRO D . n 
D 2 104 GLU 104 274 274 GLU GLU D . n 
D 2 105 VAL 105 275 275 VAL VAL D . n 
D 2 106 ALA 106 276 276 ALA ALA D . n 
D 2 107 GLU 107 277 277 GLU GLU D . n 
D 2 108 PHE 108 278 278 PHE PHE D . n 
D 2 109 VAL 109 279 279 VAL VAL D . n 
D 2 110 TYR 110 280 280 TYR TYR D . n 
D 2 111 ILE 111 281 281 ILE ILE D . n 
D 2 112 THR 112 282 282 THR THR D . n 
D 2 113 ASP 113 283 283 ASP ASP D . n 
D 2 114 ASP 114 284 284 ASP ASP D . n 
D 2 115 THR 115 285 285 THR THR D . n 
D 2 116 TYR 116 286 286 TYR TYR D . n 
D 2 117 THR 117 287 287 THR THR D . n 
D 2 118 LYS 118 288 288 LYS LYS D . n 
D 2 119 LYS 119 289 289 LYS LYS D . n 
D 2 120 GLN 120 290 290 GLN GLN D . n 
D 2 121 VAL 121 291 291 VAL VAL D . n 
D 2 122 LEU 122 292 292 LEU LEU D . n 
D 2 123 ARG 123 293 293 ARG ARG D . n 
D 2 124 MET 124 294 294 MET MET D . n 
D 2 125 GLU 125 295 295 GLU GLU D . n 
D 2 126 HIS 126 296 296 HIS HIS D . n 
D 2 127 LEU 127 297 297 LEU LEU D . n 
D 2 128 VAL 128 298 298 VAL VAL D . n 
D 2 129 LEU 129 299 299 LEU LEU D . n 
D 2 130 LYS 130 300 300 LYS LYS D . n 
D 2 131 VAL 131 301 301 VAL VAL D . n 
D 2 132 LEU 132 302 302 LEU LEU D . n 
D 2 133 ALA 133 303 303 ALA ALA D . n 
D 2 134 PHE 134 304 304 PHE PHE D . n 
D 2 135 ASP 135 305 305 ASP ASP D . n 
D 2 136 LEU 136 306 306 LEU LEU D . n 
D 2 137 ALA 137 307 307 ALA ALA D . n 
D 2 138 ALA 138 308 308 ALA ALA D . n 
D 2 139 PRO 139 309 309 PRO PRO D . n 
D 2 140 THR 140 310 310 THR THR D . n 
D 2 141 ILE 141 311 311 ILE ILE D . n 
D 2 142 ASN 142 312 312 ASN ASN D . n 
D 2 143 GLN 143 313 313 GLN GLN D . n 
D 2 144 PHE 144 314 314 PHE PHE D . n 
D 2 145 LEU 145 315 315 LEU LEU D . n 
D 2 146 THR 146 316 316 THR THR D . n 
D 2 147 GLN 147 317 317 GLN GLN D . n 
D 2 148 TYR 148 318 318 TYR TYR D . n 
D 2 149 PHE 149 319 319 PHE PHE D . n 
D 2 150 LEU 150 320 320 LEU LEU D . n 
D 2 151 HIS 151 321 321 HIS HIS D . n 
D 2 152 GLN 152 322 322 GLN GLN D . n 
D 2 153 GLN 153 323 323 GLN GLN D . n 
D 2 154 PRO 154 324 324 PRO PRO D . n 
D 2 155 ALA 155 325 325 ALA ALA D . n 
D 2 156 ASN 156 326 326 ASN ASN D . n 
D 2 157 CYS 157 327 327 CYS CYS D . n 
D 2 158 LYS 158 328 328 LYS LYS D . n 
D 2 159 VAL 159 329 329 VAL VAL D . n 
D 2 160 GLU 160 330 330 GLU GLU D . n 
D 2 161 SER 161 331 331 SER SER D . n 
D 2 162 LEU 162 332 332 LEU LEU D . n 
D 2 163 ALA 163 333 333 ALA ALA D . n 
D 2 164 MET 164 334 334 MET MET D . n 
D 2 165 PHE 165 335 335 PHE PHE D . n 
D 2 166 LEU 166 336 336 LEU LEU D . n 
D 2 167 GLY 167 337 337 GLY GLY D . n 
D 2 168 GLU 168 338 338 GLU GLU D . n 
D 2 169 LEU 169 339 339 LEU LEU D . n 
D 2 170 SER 170 340 340 SER SER D . n 
D 2 171 LEU 171 341 341 LEU LEU D . n 
D 2 172 ILE 172 342 342 ILE ILE D . n 
D 2 173 ASP 173 343 343 ASP ASP D . n 
D 2 174 ALA 174 344 344 ALA ALA D . n 
D 2 175 ASP 175 345 345 ASP ASP D . n 
D 2 176 PRO 176 346 346 PRO PRO D . n 
D 2 177 TYR 177 347 347 TYR TYR D . n 
D 2 178 LEU 178 348 348 LEU LEU D . n 
D 2 179 LYS 179 349 349 LYS LYS D . n 
D 2 180 TYR 180 350 350 TYR TYR D . n 
D 2 181 LEU 181 351 351 LEU LEU D . n 
D 2 182 PRO 182 352 352 PRO PRO D . n 
D 2 183 SER 183 353 353 SER SER D . n 
D 2 184 VAL 184 354 354 VAL VAL D . n 
D 2 185 ILE 185 355 355 ILE ILE D . n 
D 2 186 ALA 186 356 356 ALA ALA D . n 
D 2 187 ALA 187 357 357 ALA ALA D . n 
D 2 188 ALA 188 358 358 ALA ALA D . n 
D 2 189 ALA 189 359 359 ALA ALA D . n 
D 2 190 PHE 190 360 360 PHE PHE D . n 
D 2 191 HIS 191 361 361 HIS HIS D . n 
D 2 192 LEU 192 362 362 LEU LEU D . n 
D 2 193 ALA 193 363 363 ALA ALA D . n 
D 2 194 LEU 194 364 364 LEU LEU D . n 
D 2 195 TYR 195 365 365 TYR TYR D . n 
D 2 196 THR 196 366 366 THR THR D . n 
D 2 197 VAL 197 367 367 VAL VAL D . n 
D 2 198 THR 198 368 368 THR THR D . n 
D 2 199 GLY 199 369 369 GLY GLY D . n 
D 2 200 GLN 200 370 370 GLN GLN D . n 
D 2 201 SER 201 371 371 SER SER D . n 
D 2 202 TRP 202 372 372 TRP TRP D . n 
D 2 203 PRO 203 373 373 PRO PRO D . n 
D 2 204 GLU 204 374 374 GLU GLU D . n 
D 2 205 SER 205 375 375 SER SER D . n 
D 2 206 LEU 206 376 376 LEU LEU D . n 
D 2 207 VAL 207 377 377 VAL VAL D . n 
D 2 208 GLN 208 378 378 GLN GLN D . n 
D 2 209 LYS 209 379 379 LYS LYS D . n 
D 2 210 THR 210 380 380 THR THR D . n 
D 2 211 GLY 211 381 381 GLY GLY D . n 
D 2 212 TYR 212 382 382 TYR TYR D . n 
D 2 213 THR 213 383 383 THR THR D . n 
D 2 214 LEU 214 384 384 LEU LEU D . n 
D 2 215 GLU 215 385 385 GLU GLU D . n 
D 2 216 THR 216 386 386 THR THR D . n 
D 2 217 LEU 217 387 387 LEU LEU D . n 
D 2 218 LYS 218 388 388 LYS LYS D . n 
D 2 219 PRO 219 389 389 PRO PRO D . n 
D 2 220 CYS 220 390 390 CYS CYS D . n 
D 2 221 LEU 221 391 391 LEU LEU D . n 
D 2 222 LEU 222 392 392 LEU LEU D . n 
D 2 223 ASP 223 393 393 ASP ASP D . n 
D 2 224 LEU 224 394 394 LEU LEU D . n 
D 2 225 HIS 225 395 395 HIS HIS D . n 
D 2 226 GLN 226 396 396 GLN GLN D . n 
D 2 227 THR 227 397 397 THR THR D . n 
D 2 228 TYR 228 398 398 TYR TYR D . n 
D 2 229 LEU 229 399 399 LEU LEU D . n 
D 2 230 ARG 230 400 400 ARG ARG D . n 
D 2 231 ALA 231 401 401 ALA ALA D . n 
D 2 232 PRO 232 402 402 PRO PRO D . n 
D 2 233 GLN 233 403 403 GLN GLN D . n 
D 2 234 HIS 234 404 404 HIS HIS D . n 
D 2 235 ALA 235 405 405 ALA ALA D . n 
D 2 236 GLN 236 406 406 GLN GLN D . n 
D 2 237 GLN 237 407 407 GLN GLN D . n 
D 2 238 SER 238 408 408 SER SER D . n 
D 2 239 ILE 239 409 409 ILE ILE D . n 
D 2 240 ARG 240 410 410 ARG ARG D . n 
D 2 241 GLU 241 411 411 GLU GLU D . n 
D 2 242 LYS 242 412 412 LYS LYS D . n 
D 2 243 TYR 243 413 413 TYR TYR D . n 
D 2 244 LYS 244 414 414 LYS LYS D . n 
D 2 245 ASN 245 415 415 ASN ASN D . n 
D 2 246 SER 246 416 416 SER SER D . n 
D 2 247 LYS 247 417 417 LYS LYS D . n 
D 2 248 TYR 248 418 418 TYR TYR D . n 
D 2 249 HIS 249 419 419 HIS HIS D . n 
D 2 250 GLY 250 420 420 GLY GLY D . n 
D 2 251 VAL 251 421 421 VAL VAL D . n 
D 2 252 SER 252 422 422 SER SER D . n 
D 2 253 LEU 253 423 423 LEU LEU D . n 
D 2 254 LEU 254 424 424 LEU LEU D . n 
D 2 255 ASN 255 425 425 ASN ASN D . n 
D 2 256 PRO 256 426 426 PRO PRO D . n 
D 2 257 PRO 257 427 427 PRO PRO D . n 
D 2 258 GLU 258 428 428 GLU GLU D . n 
D 2 259 THR 259 429 429 THR THR D . n 
D 2 260 LEU 260 430 430 LEU LEU D . n 
D 2 261 ASN 261 431 431 ASN ASN D . n 
D 2 262 VAL 262 432 432 VAL VAL D . n 
D 2 263 HIS 263 433 ?   ?   ?   D . n 
D 2 264 HIS 264 434 ?   ?   ?   D . n 
D 2 265 HIS 265 435 ?   ?   ?   D . n 
D 2 266 HIS 266 436 ?   ?   ?   D . n 
D 2 267 HIS 267 437 ?   ?   ?   D . n 
D 2 268 HIS 268 438 ?   ?   ?   D . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        IJU 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   IJU 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 IJU 1   301 596 IJU DRG A . 
F 3 IJU 1   301 475 IJU DRG C . 
G 4 HOH 1   401 561 HOH HOH A . 
G 4 HOH 2   402 468 HOH HOH A . 
G 4 HOH 3   403 408 HOH HOH A . 
G 4 HOH 4   404 413 HOH HOH A . 
G 4 HOH 5   405 467 HOH HOH A . 
G 4 HOH 6   406 432 HOH HOH A . 
G 4 HOH 7   407 33  HOH HOH A . 
G 4 HOH 8   408 465 HOH HOH A . 
G 4 HOH 9   409 440 HOH HOH A . 
G 4 HOH 10  410 525 HOH HOH A . 
G 4 HOH 11  411 479 HOH HOH A . 
G 4 HOH 12  412 410 HOH HOH A . 
G 4 HOH 13  413 404 HOH HOH A . 
G 4 HOH 14  414 159 HOH HOH A . 
G 4 HOH 15  415 422 HOH HOH A . 
G 4 HOH 16  416 436 HOH HOH A . 
G 4 HOH 17  417 497 HOH HOH A . 
G 4 HOH 18  418 411 HOH HOH A . 
G 4 HOH 19  419 110 HOH HOH A . 
G 4 HOH 20  420 474 HOH HOH A . 
G 4 HOH 21  421 120 HOH HOH A . 
G 4 HOH 22  422 486 HOH HOH A . 
G 4 HOH 23  423 430 HOH HOH A . 
G 4 HOH 24  424 528 HOH HOH A . 
G 4 HOH 25  425 459 HOH HOH A . 
G 4 HOH 26  426 119 HOH HOH A . 
G 4 HOH 27  427 580 HOH HOH A . 
G 4 HOH 28  428 461 HOH HOH A . 
G 4 HOH 29  429 428 HOH HOH A . 
G 4 HOH 30  430 498 HOH HOH A . 
G 4 HOH 31  431 464 HOH HOH A . 
G 4 HOH 32  432 63  HOH HOH A . 
G 4 HOH 33  433 478 HOH HOH A . 
G 4 HOH 34  434 451 HOH HOH A . 
G 4 HOH 35  435 437 HOH HOH A . 
G 4 HOH 36  436 477 HOH HOH A . 
G 4 HOH 37  437 469 HOH HOH A . 
G 4 HOH 38  438 483 HOH HOH A . 
G 4 HOH 39  439 402 HOH HOH A . 
G 4 HOH 40  440 441 HOH HOH A . 
G 4 HOH 41  441 427 HOH HOH A . 
G 4 HOH 42  442 491 HOH HOH A . 
G 4 HOH 43  443 452 HOH HOH A . 
G 4 HOH 44  444 522 HOH HOH A . 
G 4 HOH 45  445 540 HOH HOH A . 
G 4 HOH 46  446 420 HOH HOH A . 
G 4 HOH 47  447 97  HOH HOH A . 
G 4 HOH 48  448 495 HOH HOH A . 
G 4 HOH 49  449 462 HOH HOH A . 
G 4 HOH 50  450 448 HOH HOH A . 
G 4 HOH 51  451 523 HOH HOH A . 
G 4 HOH 52  452 496 HOH HOH A . 
G 4 HOH 53  453 445 HOH HOH A . 
G 4 HOH 54  454 758 HOH HOH A . 
G 4 HOH 55  455 294 HOH HOH A . 
G 4 HOH 56  456 71  HOH HOH A . 
G 4 HOH 57  457 485 HOH HOH A . 
G 4 HOH 58  458 510 HOH HOH A . 
G 4 HOH 59  459 455 HOH HOH A . 
G 4 HOH 60  460 23  HOH HOH A . 
G 4 HOH 61  461 457 HOH HOH A . 
G 4 HOH 62  462 539 HOH HOH A . 
G 4 HOH 63  463 484 HOH HOH A . 
G 4 HOH 64  464 439 HOH HOH A . 
G 4 HOH 65  465 517 HOH HOH A . 
G 4 HOH 66  466 520 HOH HOH A . 
G 4 HOH 67  467 493 HOH HOH A . 
G 4 HOH 68  468 512 HOH HOH A . 
G 4 HOH 69  469 429 HOH HOH A . 
G 4 HOH 70  470 490 HOH HOH A . 
G 4 HOH 71  471 435 HOH HOH A . 
G 4 HOH 72  472 109 HOH HOH A . 
G 4 HOH 73  473 438 HOH HOH A . 
G 4 HOH 74  474 447 HOH HOH A . 
G 4 HOH 75  475 174 HOH HOH A . 
G 4 HOH 76  476 548 HOH HOH A . 
G 4 HOH 77  477 879 HOH HOH A . 
G 4 HOH 78  478 554 HOH HOH A . 
G 4 HOH 79  479 87  HOH HOH A . 
G 4 HOH 80  480 500 HOH HOH A . 
G 4 HOH 81  481 433 HOH HOH A . 
G 4 HOH 82  482 128 HOH HOH A . 
G 4 HOH 83  483 456 HOH HOH A . 
G 4 HOH 84  484 878 HOH HOH A . 
G 4 HOH 85  485 37  HOH HOH A . 
G 4 HOH 86  486 442 HOH HOH A . 
G 4 HOH 87  487 507 HOH HOH A . 
G 4 HOH 88  488 204 HOH HOH A . 
G 4 HOH 89  489 544 HOH HOH A . 
G 4 HOH 90  490 156 HOH HOH A . 
G 4 HOH 91  491 556 HOH HOH A . 
G 4 HOH 92  492 256 HOH HOH A . 
G 4 HOH 93  493 553 HOH HOH A . 
G 4 HOH 94  494 532 HOH HOH A . 
G 4 HOH 95  495 527 HOH HOH A . 
G 4 HOH 96  496 526 HOH HOH A . 
G 4 HOH 97  497 625 HOH HOH A . 
G 4 HOH 98  498 524 HOH HOH A . 
G 4 HOH 99  499 44  HOH HOH A . 
G 4 HOH 100 500 85  HOH HOH A . 
G 4 HOH 101 501 569 HOH HOH A . 
G 4 HOH 102 502 75  HOH HOH A . 
G 4 HOH 103 503 466 HOH HOH A . 
G 4 HOH 104 504 218 HOH HOH A . 
G 4 HOH 105 505 550 HOH HOH A . 
G 4 HOH 106 506 535 HOH HOH A . 
G 4 HOH 107 507 372 HOH HOH A . 
G 4 HOH 108 508 534 HOH HOH A . 
G 4 HOH 109 509 533 HOH HOH A . 
G 4 HOH 110 510 559 HOH HOH A . 
G 4 HOH 111 511 542 HOH HOH A . 
G 4 HOH 112 512 573 HOH HOH A . 
G 4 HOH 113 513 568 HOH HOH A . 
G 4 HOH 114 514 287 HOH HOH A . 
G 4 HOH 115 515 96  HOH HOH A . 
G 4 HOH 116 516 36  HOH HOH A . 
G 4 HOH 117 517 570 HOH HOH A . 
G 4 HOH 118 518 565 HOH HOH A . 
G 4 HOH 119 519 578 HOH HOH A . 
G 4 HOH 120 520 339 HOH HOH A . 
G 4 HOH 121 521 595 HOH HOH A . 
G 4 HOH 122 522 112 HOH HOH A . 
G 4 HOH 123 523 876 HOH HOH A . 
G 4 HOH 124 524 582 HOH HOH A . 
G 4 HOH 125 525 587 HOH HOH A . 
G 4 HOH 126 526 807 HOH HOH A . 
G 4 HOH 127 527 98  HOH HOH A . 
G 4 HOH 128 528 813 HOH HOH A . 
G 4 HOH 129 529 818 HOH HOH A . 
G 4 HOH 130 530 788 HOH HOH A . 
G 4 HOH 131 531 588 HOH HOH A . 
H 4 HOH 1   501 610 HOH HOH B . 
H 4 HOH 2   502 107 HOH HOH B . 
H 4 HOH 3   503 553 HOH HOH B . 
H 4 HOH 4   504 548 HOH HOH B . 
H 4 HOH 5   505 50  HOH HOH B . 
H 4 HOH 6   506 506 HOH HOH B . 
H 4 HOH 7   507 31  HOH HOH B . 
H 4 HOH 8   508 537 HOH HOH B . 
H 4 HOH 9   509 503 HOH HOH B . 
H 4 HOH 10  510 89  HOH HOH B . 
H 4 HOH 11  511 523 HOH HOH B . 
H 4 HOH 12  512 170 HOH HOH B . 
H 4 HOH 13  513 508 HOH HOH B . 
H 4 HOH 14  514 507 HOH HOH B . 
H 4 HOH 15  515 231 HOH HOH B . 
H 4 HOH 16  516 161 HOH HOH B . 
H 4 HOH 17  517 111 HOH HOH B . 
H 4 HOH 18  518 545 HOH HOH B . 
H 4 HOH 19  519 563 HOH HOH B . 
H 4 HOH 20  520 521 HOH HOH B . 
H 4 HOH 21  521 532 HOH HOH B . 
H 4 HOH 22  522 509 HOH HOH B . 
H 4 HOH 23  523 556 HOH HOH B . 
H 4 HOH 24  524 115 HOH HOH B . 
H 4 HOH 25  525 83  HOH HOH B . 
H 4 HOH 26  526 524 HOH HOH B . 
H 4 HOH 27  527 557 HOH HOH B . 
H 4 HOH 28  528 510 HOH HOH B . 
H 4 HOH 29  529 613 HOH HOH B . 
H 4 HOH 30  530 659 HOH HOH B . 
H 4 HOH 31  531 555 HOH HOH B . 
H 4 HOH 32  532 86  HOH HOH B . 
H 4 HOH 33  533 117 HOH HOH B . 
H 4 HOH 34  534 574 HOH HOH B . 
H 4 HOH 35  535 585 HOH HOH B . 
H 4 HOH 36  536 570 HOH HOH B . 
H 4 HOH 37  537 136 HOH HOH B . 
H 4 HOH 38  538 538 HOH HOH B . 
H 4 HOH 39  539 213 HOH HOH B . 
H 4 HOH 40  540 571 HOH HOH B . 
H 4 HOH 41  541 546 HOH HOH B . 
H 4 HOH 42  542 30  HOH HOH B . 
H 4 HOH 43  543 317 HOH HOH B . 
H 4 HOH 44  544 622 HOH HOH B . 
H 4 HOH 45  545 551 HOH HOH B . 
H 4 HOH 46  546 567 HOH HOH B . 
H 4 HOH 47  547 581 HOH HOH B . 
H 4 HOH 48  548 568 HOH HOH B . 
H 4 HOH 49  549 526 HOH HOH B . 
H 4 HOH 50  550 572 HOH HOH B . 
H 4 HOH 51  551 584 HOH HOH B . 
H 4 HOH 52  552 203 HOH HOH B . 
H 4 HOH 53  553 531 HOH HOH B . 
H 4 HOH 54  554 603 HOH HOH B . 
H 4 HOH 55  555 614 HOH HOH B . 
H 4 HOH 56  556 514 HOH HOH B . 
H 4 HOH 57  557 609 HOH HOH B . 
H 4 HOH 58  558 566 HOH HOH B . 
H 4 HOH 59  559 564 HOH HOH B . 
H 4 HOH 60  560 645 HOH HOH B . 
H 4 HOH 61  561 579 HOH HOH B . 
H 4 HOH 62  562 589 HOH HOH B . 
H 4 HOH 63  563 88  HOH HOH B . 
H 4 HOH 64  564 558 HOH HOH B . 
H 4 HOH 65  565 22  HOH HOH B . 
H 4 HOH 66  566 520 HOH HOH B . 
H 4 HOH 67  567 607 HOH HOH B . 
H 4 HOH 68  568 511 HOH HOH B . 
H 4 HOH 69  569 596 HOH HOH B . 
H 4 HOH 70  570 229 HOH HOH B . 
H 4 HOH 71  571 595 HOH HOH B . 
H 4 HOH 72  572 56  HOH HOH B . 
H 4 HOH 73  573 637 HOH HOH B . 
H 4 HOH 74  574 554 HOH HOH B . 
H 4 HOH 75  575 53  HOH HOH B . 
H 4 HOH 76  576 599 HOH HOH B . 
H 4 HOH 77  577 455 HOH HOH B . 
H 4 HOH 78  578 633 HOH HOH B . 
H 4 HOH 79  579 627 HOH HOH B . 
H 4 HOH 80  580 602 HOH HOH B . 
H 4 HOH 81  581 540 HOH HOH B . 
H 4 HOH 82  582 644 HOH HOH B . 
H 4 HOH 83  583 535 HOH HOH B . 
H 4 HOH 84  584 239 HOH HOH B . 
H 4 HOH 85  585 624 HOH HOH B . 
H 4 HOH 86  586 81  HOH HOH B . 
H 4 HOH 87  587 221 HOH HOH B . 
H 4 HOH 88  588 598 HOH HOH B . 
H 4 HOH 89  589 360 HOH HOH B . 
H 4 HOH 90  590 615 HOH HOH B . 
H 4 HOH 91  591 605 HOH HOH B . 
H 4 HOH 92  592 560 HOH HOH B . 
H 4 HOH 93  593 631 HOH HOH B . 
H 4 HOH 94  594 630 HOH HOH B . 
H 4 HOH 95  595 639 HOH HOH B . 
H 4 HOH 96  596 550 HOH HOH B . 
H 4 HOH 97  597 529 HOH HOH B . 
H 4 HOH 98  598 544 HOH HOH B . 
H 4 HOH 99  599 586 HOH HOH B . 
H 4 HOH 100 600 176 HOH HOH B . 
H 4 HOH 101 601 197 HOH HOH B . 
H 4 HOH 102 602 343 HOH HOH B . 
H 4 HOH 103 603 525 HOH HOH B . 
H 4 HOH 104 604 629 HOH HOH B . 
H 4 HOH 105 605 92  HOH HOH B . 
H 4 HOH 106 606 665 HOH HOH B . 
H 4 HOH 107 607 618 HOH HOH B . 
H 4 HOH 108 608 626 HOH HOH B . 
H 4 HOH 109 609 619 HOH HOH B . 
H 4 HOH 110 610 43  HOH HOH B . 
H 4 HOH 111 611 397 HOH HOH B . 
H 4 HOH 112 612 590 HOH HOH B . 
H 4 HOH 113 613 582 HOH HOH B . 
H 4 HOH 114 614 640 HOH HOH B . 
H 4 HOH 115 615 617 HOH HOH B . 
H 4 HOH 116 616 80  HOH HOH B . 
H 4 HOH 117 617 588 HOH HOH B . 
H 4 HOH 118 618 666 HOH HOH B . 
H 4 HOH 119 619 249 HOH HOH B . 
H 4 HOH 120 620 648 HOH HOH B . 
H 4 HOH 121 621 641 HOH HOH B . 
H 4 HOH 122 622 620 HOH HOH B . 
H 4 HOH 123 623 667 HOH HOH B . 
H 4 HOH 124 624 661 HOH HOH B . 
H 4 HOH 125 625 539 HOH HOH B . 
H 4 HOH 126 626 649 HOH HOH B . 
H 4 HOH 127 627 650 HOH HOH B . 
H 4 HOH 128 628 245 HOH HOH B . 
H 4 HOH 129 629 587 HOH HOH B . 
H 4 HOH 130 630 652 HOH HOH B . 
H 4 HOH 131 631 674 HOH HOH B . 
H 4 HOH 132 632 789 HOH HOH B . 
H 4 HOH 133 633 244 HOH HOH B . 
H 4 HOH 134 634 635 HOH HOH B . 
H 4 HOH 135 635 792 HOH HOH B . 
H 4 HOH 136 636 803 HOH HOH B . 
H 4 HOH 137 637 647 HOH HOH B . 
H 4 HOH 138 638 671 HOH HOH B . 
H 4 HOH 139 639 432 HOH HOH B . 
H 4 HOH 140 640 675 HOH HOH B . 
H 4 HOH 141 641 676 HOH HOH B . 
H 4 HOH 142 642 672 HOH HOH B . 
H 4 HOH 143 643 794 HOH HOH B . 
H 4 HOH 144 644 678 HOH HOH B . 
H 4 HOH 145 645 798 HOH HOH B . 
H 4 HOH 146 646 680 HOH HOH B . 
H 4 HOH 147 647 679 HOH HOH B . 
H 4 HOH 148 648 800 HOH HOH B . 
H 4 HOH 149 649 681 HOH HOH B . 
H 4 HOH 150 650 877 HOH HOH B . 
I 4 HOH 1   401 9   HOH HOH C . 
I 4 HOH 2   402 106 HOH HOH C . 
I 4 HOH 3   403 207 HOH HOH C . 
I 4 HOH 4   404 407 HOH HOH C . 
I 4 HOH 5   405 420 HOH HOH C . 
I 4 HOH 6   406 414 HOH HOH C . 
I 4 HOH 7   407 108 HOH HOH C . 
I 4 HOH 8   408 406 HOH HOH C . 
I 4 HOH 9   409 405 HOH HOH C . 
I 4 HOH 10  410 880 HOH HOH C . 
I 4 HOH 11  411 425 HOH HOH C . 
I 4 HOH 12  412 401 HOH HOH C . 
I 4 HOH 13  413 460 HOH HOH C . 
I 4 HOH 14  414 414 HOH HOH C . 
I 4 HOH 15  415 437 HOH HOH C . 
I 4 HOH 16  416 445 HOH HOH C . 
I 4 HOH 17  417 212 HOH HOH C . 
I 4 HOH 18  418 69  HOH HOH C . 
I 4 HOH 19  419 436 HOH HOH C . 
I 4 HOH 20  420 303 HOH HOH C . 
I 4 HOH 21  421 307 HOH HOH C . 
I 4 HOH 22  422 430 HOH HOH C . 
I 4 HOH 23  423 424 HOH HOH C . 
I 4 HOH 24  424 91  HOH HOH C . 
I 4 HOH 25  425 28  HOH HOH C . 
I 4 HOH 26  426 66  HOH HOH C . 
I 4 HOH 27  427 433 HOH HOH C . 
I 4 HOH 28  428 295 HOH HOH C . 
I 4 HOH 29  429 428 HOH HOH C . 
I 4 HOH 30  430 193 HOH HOH C . 
I 4 HOH 31  431 439 HOH HOH C . 
I 4 HOH 32  432 434 HOH HOH C . 
I 4 HOH 33  433 438 HOH HOH C . 
I 4 HOH 34  434 453 HOH HOH C . 
I 4 HOH 35  435 93  HOH HOH C . 
I 4 HOH 36  436 404 HOH HOH C . 
I 4 HOH 37  437 215 HOH HOH C . 
I 4 HOH 38  438 73  HOH HOH C . 
I 4 HOH 39  439 268 HOH HOH C . 
I 4 HOH 40  440 421 HOH HOH C . 
I 4 HOH 41  441 25  HOH HOH C . 
I 4 HOH 42  442 427 HOH HOH C . 
I 4 HOH 43  443 412 HOH HOH C . 
I 4 HOH 44  444 419 HOH HOH C . 
I 4 HOH 45  445 426 HOH HOH C . 
I 4 HOH 46  446 422 HOH HOH C . 
I 4 HOH 47  447 323 HOH HOH C . 
I 4 HOH 48  448 198 HOH HOH C . 
I 4 HOH 49  449 145 HOH HOH C . 
I 4 HOH 50  450 29  HOH HOH C . 
I 4 HOH 51  451 14  HOH HOH C . 
I 4 HOH 52  452 408 HOH HOH C . 
I 4 HOH 53  453 209 HOH HOH C . 
I 4 HOH 54  454 452 HOH HOH C . 
I 4 HOH 55  455 450 HOH HOH C . 
I 4 HOH 56  456 403 HOH HOH C . 
I 4 HOH 57  457 206 HOH HOH C . 
I 4 HOH 58  458 35  HOH HOH C . 
I 4 HOH 59  459 46  HOH HOH C . 
I 4 HOH 60  460 449 HOH HOH C . 
I 4 HOH 61  461 464 HOH HOH C . 
I 4 HOH 62  462 616 HOH HOH C . 
I 4 HOH 63  463 184 HOH HOH C . 
I 4 HOH 64  464 40  HOH HOH C . 
I 4 HOH 65  465 155 HOH HOH C . 
I 4 HOH 66  466 465 HOH HOH C . 
I 4 HOH 67  467 84  HOH HOH C . 
I 4 HOH 68  468 882 HOH HOH C . 
I 4 HOH 69  469 48  HOH HOH C . 
I 4 HOH 70  470 121 HOH HOH C . 
I 4 HOH 71  471 147 HOH HOH C . 
I 4 HOH 72  472 2   HOH HOH C . 
I 4 HOH 73  473 454 HOH HOH C . 
I 4 HOH 74  474 20  HOH HOH C . 
I 4 HOH 75  475 189 HOH HOH C . 
I 4 HOH 76  476 196 HOH HOH C . 
I 4 HOH 77  477 70  HOH HOH C . 
I 4 HOH 78  478 177 HOH HOH C . 
I 4 HOH 79  479 146 HOH HOH C . 
I 4 HOH 80  480 264 HOH HOH C . 
I 4 HOH 81  481 127 HOH HOH C . 
I 4 HOH 82  482 234 HOH HOH C . 
I 4 HOH 83  483 67  HOH HOH C . 
I 4 HOH 84  484 21  HOH HOH C . 
I 4 HOH 85  485 468 HOH HOH C . 
I 4 HOH 86  486 438 HOH HOH C . 
I 4 HOH 87  487 293 HOH HOH C . 
I 4 HOH 88  488 102 HOH HOH C . 
I 4 HOH 89  489 275 HOH HOH C . 
I 4 HOH 90  490 429 HOH HOH C . 
I 4 HOH 91  491 312 HOH HOH C . 
I 4 HOH 92  492 461 HOH HOH C . 
I 4 HOH 93  493 79  HOH HOH C . 
I 4 HOH 94  494 881 HOH HOH C . 
I 4 HOH 95  495 82  HOH HOH C . 
I 4 HOH 96  496 572 HOH HOH C . 
I 4 HOH 97  497 570 HOH HOH C . 
J 4 HOH 1   501 90  HOH HOH D . 
J 4 HOH 2   502 38  HOH HOH D . 
J 4 HOH 3   503 506 HOH HOH D . 
J 4 HOH 4   504 508 HOH HOH D . 
J 4 HOH 5   505 269 HOH HOH D . 
J 4 HOH 6   506 435 HOH HOH D . 
J 4 HOH 7   507 534 HOH HOH D . 
J 4 HOH 8   508 321 HOH HOH D . 
J 4 HOH 9   509 547 HOH HOH D . 
J 4 HOH 10  510 519 HOH HOH D . 
J 4 HOH 11  511 552 HOH HOH D . 
J 4 HOH 12  512 515 HOH HOH D . 
J 4 HOH 13  513 532 HOH HOH D . 
J 4 HOH 14  514 74  HOH HOH D . 
J 4 HOH 15  515 533 HOH HOH D . 
J 4 HOH 16  516 505 HOH HOH D . 
J 4 HOH 17  517 311 HOH HOH D . 
J 4 HOH 18  518 507 HOH HOH D . 
J 4 HOH 19  519 512 HOH HOH D . 
J 4 HOH 20  520 529 HOH HOH D . 
J 4 HOH 21  521 526 HOH HOH D . 
J 4 HOH 22  522 314 HOH HOH D . 
J 4 HOH 23  523 543 HOH HOH D . 
J 4 HOH 24  524 32  HOH HOH D . 
J 4 HOH 25  525 520 HOH HOH D . 
J 4 HOH 26  526 511 HOH HOH D . 
J 4 HOH 27  527 539 HOH HOH D . 
J 4 HOH 28  528 504 HOH HOH D . 
J 4 HOH 29  529 521 HOH HOH D . 
J 4 HOH 30  530 277 HOH HOH D . 
J 4 HOH 31  531 39  HOH HOH D . 
J 4 HOH 32  532 502 HOH HOH D . 
J 4 HOH 33  533 537 HOH HOH D . 
J 4 HOH 34  534 550 HOH HOH D . 
J 4 HOH 35  535 516 HOH HOH D . 
J 4 HOH 36  536 225 HOH HOH D . 
J 4 HOH 37  537 187 HOH HOH D . 
J 4 HOH 38  538 94  HOH HOH D . 
J 4 HOH 39  539 276 HOH HOH D . 
J 4 HOH 40  540 554 HOH HOH D . 
J 4 HOH 41  541 517 HOH HOH D . 
J 4 HOH 42  542 68  HOH HOH D . 
J 4 HOH 43  543 796 HOH HOH D . 
J 4 HOH 44  544 72  HOH HOH D . 
J 4 HOH 45  545 57  HOH HOH D . 
J 4 HOH 46  546 60  HOH HOH D . 
J 4 HOH 47  547 540 HOH HOH D . 
J 4 HOH 48  548 191 HOH HOH D . 
J 4 HOH 49  549 64  HOH HOH D . 
J 4 HOH 50  550 49  HOH HOH D . 
J 4 HOH 51  551 58  HOH HOH D . 
J 4 HOH 52  552 535 HOH HOH D . 
J 4 HOH 53  553 59  HOH HOH D . 
J 4 HOH 54  554 553 HOH HOH D . 
J 4 HOH 55  555 265 HOH HOH D . 
J 4 HOH 56  556 118 HOH HOH D . 
J 4 HOH 57  557 42  HOH HOH D . 
J 4 HOH 58  558 51  HOH HOH D . 
J 4 HOH 59  559 528 HOH HOH D . 
J 4 HOH 60  560 561 HOH HOH D . 
J 4 HOH 61  561 558 HOH HOH D . 
J 4 HOH 62  562 569 HOH HOH D . 
J 4 HOH 63  563 546 HOH HOH D . 
J 4 HOH 64  564 19  HOH HOH D . 
J 4 HOH 65  565 266 HOH HOH D . 
J 4 HOH 66  566 562 HOH HOH D . 
J 4 HOH 67  567 201 HOH HOH D . 
J 4 HOH 68  568 137 HOH HOH D . 
J 4 HOH 69  569 105 HOH HOH D . 
J 4 HOH 70  570 850 HOH HOH D . 
J 4 HOH 71  571 560 HOH HOH D . 
J 4 HOH 72  572 100 HOH HOH D . 
J 4 HOH 73  573 797 HOH HOH D . 
J 4 HOH 74  574 571 HOH HOH D . 
J 4 HOH 75  575 78  HOH HOH D . 
J 4 HOH 76  576 568 HOH HOH D . 
J 4 HOH 77  577 236 HOH HOH D . 
J 4 HOH 78  578 790 HOH HOH D . 
J 4 HOH 79  579 812 HOH HOH D . 
J 4 HOH 80  580 551 HOH HOH D . 
J 4 HOH 81  581 65  HOH HOH D . 
J 4 HOH 82  582 811 HOH HOH D . 
J 4 HOH 83  583 578 HOH HOH D . 
J 4 HOH 84  584 799 HOH HOH D . 
J 4 HOH 85  585 579 HOH HOH D . 
J 4 HOH 86  586 802 HOH HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0425 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2    ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        4 
# 
_cell.angle_alpha                  90 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9ESU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     74.127 
_cell.length_a_esd                 ? 
_cell.length_b                     133.735 
_cell.length_b_esd                 ? 
_cell.length_c                     147.673 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9ESU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9ESU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.85 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.89 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'Protein at 10 mg/ml. 0.6 to 0.8 M KCl, 0.9 to 1.2 M (NH4)2SO4, and 100 mM HEPES pH 7.0' 
_exptl_crystal_grow.pdbx_pH_range   7-7.5 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-02-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.89842 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.89842 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9ESU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.38 
_reflns.d_resolution_low                               147.67 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     54967 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           92 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.207 
_reflns.pdbx_Rpim_I_all                                0.077 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.192 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
10.1 147.67 ? 35.2 ? ? ? ? 911  ? ? ? ? ? ? ? ? ? ? ? 12.2 ? ? ? 0.045 0.016 ? 1 1 0.999 ? ? 100 ? 0.042 ? ? ? ? ? ? ? ? ? 
2.38 2.45   ? 1.2  ? ? ? ? 4814 ? ? ? ? ? ? ? ? ? ? ? 13.4 ? ? ? 2.184 0.828 ? 2 1 0.607 ? ? 100 ? 2.019 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            -2.155 
_refine.aniso_B[1][2]                            0.000 
_refine.aniso_B[1][3]                            0.000 
_refine.aniso_B[2][2]                            1.011 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            1.145 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               58.344 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.957 
_refine.correlation_coeff_Fo_to_Fc_free          0.946 
_refine.details                                  'Hydrogens have not been used' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9ESU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.396 
_refine.ls_d_res_low                             99.324 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     53268 
_refine.ls_number_reflns_R_free                  2703 
_refine.ls_number_reflns_R_work                  50565 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    91.025 
_refine.ls_percent_reflns_R_free                 5.074 
_refine.ls_R_factor_all                          0.214 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2164 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2135 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      0.206 
_refine.ls_wR_factor_R_work                      0.201 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.475 
_refine.pdbx_overall_ESU_R_Free                  0.237 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    0.9418 
_refine.pdbx_average_fsc_free                    0.9400 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.396 
_refine_hist.d_res_low                        99.324 
_refine_hist.number_atoms_solvent             464 
_refine_hist.number_atoms_total               9518 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        9034 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         20 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.012  9352  ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 1.593  1.849  12707 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 5.890  5.000  1128  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 19.266 5.000  45    ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 15.105 10.000 1626  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 16.986 10.000 405   ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.097  0.200  1434  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.020  7016  ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.221  0.200  4585  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.315  0.200  6349  ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.151  0.200  455   ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.303  0.200  56    ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.257  0.200  13    ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 4.284  5.654  4512  ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 6.635  10.165 5640  ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.826  5.940  4840  ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 8.705  10.750 7067  ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 11.984 62.140 14446 ? r_lrange_it                    ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.396  2.458  4262 . 167 3613 88.6908  . 1.289 . . 1.289 . . . . . 1.355 . 20 . 0.719 0.661 1.300 
'X-RAY DIFFRACTION' 2.458  2.525  4147 . 242 3905 100.0000 . 0.648 . . 0.649 . . . . . 0.655 . 20 . 0.834 0.840 0.633 
'X-RAY DIFFRACTION' 2.525  2.598  4063 . 214 3849 100.0000 . 0.339 . . 0.341 . . . . . 0.344 . 20 . 0.940 0.947 0.306 
'X-RAY DIFFRACTION' 2.598  2.678  3933 . 109 2106 56.3183  . 0.284 . . 0.284 . . . . . 0.283 . 20 . 0.950 0.950 0.283 
'X-RAY DIFFRACTION' 2.678  2.766  3812 . 166 3270 90.1364  . 0.259 . . 0.260 . . . . . 0.252 . 20 . 0.957 0.965 0.241 
'X-RAY DIFFRACTION' 2.766  2.863  3689 . 174 3515 100.0000 . 0.237 . . 0.238 . . . . . 0.228 . 20 . 0.965 0.965 0.235 
'X-RAY DIFFRACTION' 2.863  2.971  3583 . 209 3374 100.0000 . 0.243 . . 0.243 . . . . . 0.233 . 20 . 0.963 0.960 0.251 
'X-RAY DIFFRACTION' 2.971  3.092  3432 . 175 3257 100.0000 . 0.236 . . 0.237 . . . . . 0.227 . 20 . 0.969 0.974 0.221 
'X-RAY DIFFRACTION' 3.092  3.229  3320 . 164 3156 100.0000 . 0.227 . . 0.227 . . . . . 0.216 . 20 . 0.971 0.974 0.217 
'X-RAY DIFFRACTION' 3.229  3.387  3169 . 154 3015 100.0000 . 0.211 . . 0.211 . . . . . 0.201 . 20 . 0.977 0.975 0.223 
'X-RAY DIFFRACTION' 3.387  3.570  3009 . 90  1737 60.7178  . 0.196 . . 0.196 . . . . . 0.188 . 20 . 0.980 0.987 0.191 
'X-RAY DIFFRACTION' 3.570  3.786  2859 . 122 2121 78.4540  . 0.184 . . 0.185 . . . . . 0.177 . 20 . 0.981 0.987 0.171 
'X-RAY DIFFRACTION' 3.786  4.047  2699 . 80  1765 68.3587  . 0.166 . . 0.166 . . . . . 0.161 . 20 . 0.984 0.985 0.166 
'X-RAY DIFFRACTION' 4.047  4.371  2534 . 140 2394 100.0000 . 0.148 . . 0.149 . . . . . 0.145 . 20 . 0.988 0.990 0.147 
'X-RAY DIFFRACTION' 4.371  4.787  2321 . 119 2202 100.0000 . 0.141 . . 0.140 . . . . . 0.137 . 20 . 0.988 0.985 0.152 
'X-RAY DIFFRACTION' 4.787  5.350  2129 . 96  2033 100.0000 . 0.157 . . 0.158 . . . . . 0.156 . 20 . 0.986 0.987 0.145 
'X-RAY DIFFRACTION' 5.350  6.175  1893 . 98  1795 100.0000 . 0.196 . . 0.196 . . . . . 0.190 . 20 . 0.981 0.984 0.196 
'X-RAY DIFFRACTION' 6.175  7.555  1603 . 92  1510 99.9376  . 0.202 . . 0.200 . . . . . 0.198 . 20 . 0.980 0.975 0.231 
'X-RAY DIFFRACTION' 7.555  10.654 1279 . 55  1224 100.0000 . 0.147 . . 0.147 . . . . . 0.154 . 20 . 0.988 0.987 0.155 
'X-RAY DIFFRACTION' 10.654 99.324 763  . 37  724  99.7379  . 0.222 . . 0.216 . . . . . 0.247 . 20 . 0.967 0.891 0.356 
# 
_struct.entry_id                     9ESU 
_struct.title                        'CDK2-cyclin A in complex with FragLite 20' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9ESU 
_struct_keywords.text            'cyclin-dependent kinase, FragLite, CDK2, cyclin A, Fragment, CELL CYCLE' 
_struct_keywords.pdbx_keywords   'CELL CYCLE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP CDK2_HUMAN  P24941 ? 1 
;MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
;
1   
2 UNP CCNA2_BOVIN P30274 ? 2 
;VNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRG
KLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVES
LAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIRE
KYKNSKYHGVSLLNPPETLNV
;
170 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9ESU A 5 ? 302 ? P24941 1   ? 298 ? 1   298 
2 2 9ESU B 2 ? 262 ? P30274 170 ? 430 ? 172 432 
3 1 9ESU C 5 ? 302 ? P24941 1   ? 298 ? 1   298 
4 2 9ESU D 2 ? 262 ? P30274 170 ? 430 ? 172 432 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9ESU GLY A 1   ? UNP P24941 ? ? 'expression tag' -3  1  
1 9ESU PRO A 2   ? UNP P24941 ? ? 'expression tag' -2  2  
1 9ESU GLY A 3   ? UNP P24941 ? ? 'expression tag' -1  3  
1 9ESU SER A 4   ? UNP P24941 ? ? 'expression tag' 0   4  
2 9ESU GLY B 1   ? UNP P30274 ? ? 'expression tag' 171 5  
2 9ESU HIS B 263 ? UNP P30274 ? ? 'expression tag' 433 6  
2 9ESU HIS B 264 ? UNP P30274 ? ? 'expression tag' 434 7  
2 9ESU HIS B 265 ? UNP P30274 ? ? 'expression tag' 435 8  
2 9ESU HIS B 266 ? UNP P30274 ? ? 'expression tag' 436 9  
2 9ESU HIS B 267 ? UNP P30274 ? ? 'expression tag' 437 10 
2 9ESU HIS B 268 ? UNP P30274 ? ? 'expression tag' 438 11 
3 9ESU GLY C 1   ? UNP P24941 ? ? 'expression tag' -3  12 
3 9ESU PRO C 2   ? UNP P24941 ? ? 'expression tag' -2  13 
3 9ESU GLY C 3   ? UNP P24941 ? ? 'expression tag' -1  14 
3 9ESU SER C 4   ? UNP P24941 ? ? 'expression tag' 0   15 
4 9ESU GLY D 1   ? UNP P30274 ? ? 'expression tag' 171 16 
4 9ESU HIS D 263 ? UNP P30274 ? ? 'expression tag' 433 17 
4 9ESU HIS D 264 ? UNP P30274 ? ? 'expression tag' 434 18 
4 9ESU HIS D 265 ? UNP P30274 ? ? 'expression tag' 435 19 
4 9ESU HIS D 266 ? UNP P30274 ? ? 'expression tag' 436 20 
4 9ESU HIS D 267 ? UNP P30274 ? ? 'expression tag' 437 21 
4 9ESU HIS D 268 ? UNP P30274 ? ? 'expression tag' 438 22 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3650  ? 
1 MORE         -15   ? 
1 'SSA (A^2)'  23700 ? 
2 'ABSA (A^2)' 3610  ? 
2 MORE         -18   ? 
2 'SSA (A^2)'  23270 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,E,G,H 
2 1 C,D,F,I,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 4   ? GLU A 6   ? SER A 0   GLU A 2   5 ? 3  
HELX_P HELX_P2  AA2 PRO A 49  ? LEU A 62  ? PRO A 45  LEU A 58  1 ? 14 
HELX_P HELX_P3  AA3 LEU A 91  ? SER A 98  ? LEU A 87  SER A 94  1 ? 8  
HELX_P HELX_P4  AA4 PRO A 104 ? HIS A 125 ? PRO A 100 HIS A 121 1 ? 22 
HELX_P HELX_P5  AA5 LYS A 133 ? GLN A 135 ? LYS A 129 GLN A 131 5 ? 3  
HELX_P HELX_P6  AA6 THR A 169 ? ARG A 173 ? THR A 165 ARG A 169 5 ? 5  
HELX_P HELX_P7  AA7 ALA A 174 ? LEU A 179 ? ALA A 170 LEU A 175 1 ? 6  
HELX_P HELX_P8  AA8 THR A 186 ? ARG A 203 ? THR A 182 ARG A 199 1 ? 18 
HELX_P HELX_P9  AA9 SER A 211 ? GLY A 224 ? SER A 207 GLY A 220 1 ? 14 
HELX_P HELX_P10 AB1 GLY A 233 ? MET A 237 ? GLY A 229 MET A 233 5 ? 5  
HELX_P HELX_P11 AB2 ASP A 260 ? LEU A 271 ? ASP A 256 LEU A 267 1 ? 12 
HELX_P HELX_P12 AB3 SER A 280 ? LEU A 285 ? SER A 276 LEU A 281 1 ? 6  
HELX_P HELX_P13 AB4 ALA A 286 ? GLN A 291 ? ALA A 282 GLN A 287 5 ? 6  
HELX_P HELX_P14 AB5 GLY B 1   ? VAL B 5   ? GLY B 171 VAL B 175 5 ? 5  
HELX_P HELX_P15 AB6 TYR B 8   ? CYS B 23  ? TYR B 178 CYS B 193 1 ? 16 
HELX_P HELX_P16 AB7 THR B 37  ? TYR B 55  ? THR B 207 TYR B 225 1 ? 19 
HELX_P HELX_P17 AB8 GLN B 58  ? MET B 76  ? GLN B 228 MET B 246 1 ? 19 
HELX_P HELX_P18 AB9 LEU B 79  ? GLU B 99  ? LEU B 249 GLU B 269 1 ? 21 
HELX_P HELX_P19 AC1 GLU B 104 ? THR B 112 ? GLU B 274 THR B 282 1 ? 9  
HELX_P HELX_P20 AC2 THR B 117 ? ALA B 133 ? THR B 287 ALA B 303 1 ? 17 
HELX_P HELX_P21 AC3 THR B 140 ? LEU B 150 ? THR B 310 LEU B 320 1 ? 11 
HELX_P HELX_P22 AC4 ASN B 156 ? ASP B 173 ? ASN B 326 ASP B 343 1 ? 18 
HELX_P HELX_P23 AC5 ASP B 173 ? LEU B 178 ? ASP B 343 LEU B 348 1 ? 6  
HELX_P HELX_P24 AC6 LEU B 181 ? GLY B 199 ? LEU B 351 GLY B 369 1 ? 19 
HELX_P HELX_P25 AC7 PRO B 203 ? GLY B 211 ? PRO B 373 GLY B 381 1 ? 9  
HELX_P HELX_P26 AC8 THR B 213 ? ALA B 231 ? THR B 383 ALA B 401 1 ? 19 
HELX_P HELX_P27 AC9 PRO B 232 ? HIS B 234 ? PRO B 402 HIS B 404 5 ? 3  
HELX_P HELX_P28 AD1 GLN B 237 ? TYR B 243 ? GLN B 407 TYR B 413 1 ? 7  
HELX_P HELX_P29 AD2 LYS B 244 ? HIS B 249 ? LYS B 414 HIS B 419 5 ? 6  
HELX_P HELX_P30 AD3 GLY B 250 ? LEU B 254 ? GLY B 420 LEU B 424 5 ? 5  
HELX_P HELX_P31 AD4 PRO C 49  ? LEU C 62  ? PRO C 45  LEU C 58  1 ? 14 
HELX_P HELX_P32 AD5 LEU C 91  ? SER C 98  ? LEU C 87  SER C 94  1 ? 8  
HELX_P HELX_P33 AD6 PRO C 104 ? HIS C 125 ? PRO C 100 HIS C 121 1 ? 22 
HELX_P HELX_P34 AD7 LYS C 133 ? GLN C 135 ? LYS C 129 GLN C 131 5 ? 3  
HELX_P HELX_P35 AD8 THR C 169 ? ARG C 173 ? THR C 165 ARG C 169 5 ? 5  
HELX_P HELX_P36 AD9 ALA C 174 ? LEU C 179 ? ALA C 170 LEU C 175 1 ? 6  
HELX_P HELX_P37 AE1 THR C 186 ? ARG C 203 ? THR C 182 ARG C 199 1 ? 18 
HELX_P HELX_P38 AE2 SER C 211 ? GLY C 224 ? SER C 207 GLY C 220 1 ? 14 
HELX_P HELX_P39 AE3 GLY C 233 ? MET C 237 ? GLY C 229 MET C 233 5 ? 5  
HELX_P HELX_P40 AE4 ASP C 251 ? VAL C 256 ? ASP C 247 VAL C 252 1 ? 6  
HELX_P HELX_P41 AE5 ASP C 260 ? LEU C 271 ? ASP C 256 LEU C 267 1 ? 12 
HELX_P HELX_P42 AE6 SER C 280 ? HIS C 287 ? SER C 276 HIS C 283 1 ? 8  
HELX_P HELX_P43 AE7 PRO C 288 ? GLN C 291 ? PRO C 284 GLN C 287 5 ? 4  
HELX_P HELX_P44 AE8 GLY D 1   ? VAL D 5   ? GLY D 171 VAL D 175 5 ? 5  
HELX_P HELX_P45 AE9 TYR D 8   ? CYS D 23  ? TYR D 178 CYS D 193 1 ? 16 
HELX_P HELX_P46 AF1 TYR D 29  ? GLN D 33  ? TYR D 199 GLN D 203 5 ? 5  
HELX_P HELX_P47 AF2 THR D 37  ? TYR D 55  ? THR D 207 TYR D 225 1 ? 19 
HELX_P HELX_P48 AF3 GLN D 58  ? SER D 74  ? GLN D 228 SER D 244 1 ? 17 
HELX_P HELX_P49 AF4 LEU D 79  ? GLU D 99  ? LEU D 249 GLU D 269 1 ? 21 
HELX_P HELX_P50 AF5 GLU D 104 ? ILE D 111 ? GLU D 274 ILE D 281 1 ? 8  
HELX_P HELX_P51 AF6 THR D 117 ? LEU D 132 ? THR D 287 LEU D 302 1 ? 16 
HELX_P HELX_P52 AF7 THR D 140 ? LEU D 150 ? THR D 310 LEU D 320 1 ? 11 
HELX_P HELX_P53 AF8 ASN D 156 ? ASP D 173 ? ASN D 326 ASP D 343 1 ? 18 
HELX_P HELX_P54 AF9 ASP D 173 ? LEU D 178 ? ASP D 343 LEU D 348 1 ? 6  
HELX_P HELX_P55 AG1 LEU D 181 ? GLY D 199 ? LEU D 351 GLY D 369 1 ? 19 
HELX_P HELX_P56 AG2 PRO D 203 ? GLY D 211 ? PRO D 373 GLY D 381 1 ? 9  
HELX_P HELX_P57 AG3 LEU D 217 ? ALA D 231 ? LEU D 387 ALA D 401 1 ? 15 
HELX_P HELX_P58 AG4 PRO D 232 ? HIS D 234 ? PRO D 402 HIS D 404 5 ? 3  
HELX_P HELX_P59 AG5 GLN D 237 ? TYR D 243 ? GLN D 407 TYR D 413 1 ? 7  
HELX_P HELX_P60 AG6 LYS D 244 ? HIS D 249 ? LYS D 414 HIS D 419 5 ? 6  
HELX_P HELX_P61 AG7 GLY D 250 ? LEU D 254 ? GLY D 420 LEU D 424 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A TYR 163 C ? ? ? 1_555 A TPO 164 N ? ? A TYR 159 A TPO 160 1_555 ? ? ? ? ? ? ? 1.320 ? ? 
covale2 covale both ? A TPO 164 C ? ? ? 1_555 A HIS 165 N ? ? A TPO 160 A HIS 161 1_555 ? ? ? ? ? ? ? 1.341 ? ? 
covale3 covale both ? C TYR 163 C ? ? ? 1_555 C TPO 164 N ? ? C TYR 159 C TPO 160 1_555 ? ? ? ? ? ? ? 1.337 ? ? 
covale4 covale both ? C TPO 164 C ? ? ? 1_555 C HIS 165 N ? ? C TPO 160 C HIS 161 1_555 ? ? ? ? ? ? ? 1.345 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 TPO A 164 ? . . . . TPO A 160 ? 1_555 . . . . . . . THR 1 TPO Phosphorylation 'Named protein modification' 
2 TPO C 164 ? . . . . TPO C 160 ? 1_555 . . . . . . . THR 1 TPO Phosphorylation 'Named protein modification' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 VAL 158 A . ? VAL 154 A PRO 159 A ? PRO 155 A 1 -5.95 
2 GLN 153 B . ? GLN 323 B PRO 154 B ? PRO 324 B 1 -1.85 
3 ASP 175 B . ? ASP 345 B PRO 176 B ? PRO 346 B 1 8.34  
4 VAL 158 C . ? VAL 154 C PRO 159 C ? PRO 155 C 1 -3.34 
5 GLN 153 D . ? GLN 323 D PRO 154 D ? PRO 324 D 1 3.18  
6 ASP 175 D . ? ASP 345 D PRO 176 D ? PRO 346 D 1 4.52  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 5 ? 
AA5 ? 3 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 8   ? GLY A 17  ? PHE A 4   GLY A 13  
AA1 2 GLY A 20  ? ASN A 27  ? GLY A 16  ASN A 23  
AA1 3 VAL A 33  ? ILE A 39  ? VAL A 29  ILE A 35  
AA1 4 LEU A 80  ? GLU A 85  ? LEU A 76  GLU A 81  
AA1 5 LEU A 70  ? HIS A 75  ? LEU A 66  HIS A 71  
AA2 1 GLN A 89  ? ASP A 90  ? GLN A 85  ASP A 86  
AA2 2 LEU A 137 ? ILE A 139 ? LEU A 133 ILE A 135 
AA2 3 ILE A 145 ? LEU A 147 ? ILE A 141 LEU A 143 
AA3 1 VAL A 127 ? LEU A 128 ? VAL A 123 LEU A 124 
AA3 2 ARG A 154 ? ALA A 155 ? ARG A 150 ALA A 151 
AA4 1 PHE C 8   ? GLU C 16  ? PHE C 4   GLU C 12  
AA4 2 VAL C 21  ? ASN C 27  ? VAL C 17  ASN C 23  
AA4 3 VAL C 33  ? ARG C 40  ? VAL C 29  ARG C 36  
AA4 4 LYS C 79  ? GLU C 85  ? LYS C 75  GLU C 81  
AA4 5 LEU C 70  ? HIS C 75  ? LEU C 66  HIS C 71  
AA5 1 GLN C 89  ? ASP C 90  ? GLN C 85  ASP C 86  
AA5 2 LEU C 137 ? ILE C 139 ? LEU C 133 ILE C 135 
AA5 3 ILE C 145 ? LEU C 147 ? ILE C 141 LEU C 143 
AA6 1 VAL C 127 ? LEU C 128 ? VAL C 123 LEU C 124 
AA6 2 ARG C 154 ? ALA C 155 ? ARG C 150 ALA C 151 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 14  ? N ILE A 10  O VAL A 22  ? O VAL A 18  
AA1 2 3 N ALA A 25  ? N ALA A 21  O VAL A 34  ? O VAL A 30  
AA1 3 4 N ALA A 35  ? N ALA A 31  O PHE A 84  ? O PHE A 80  
AA1 4 5 O VAL A 83  ? O VAL A 79  N LEU A 71  ? N LEU A 67  
AA2 1 2 N GLN A 89  ? N GLN A 85  O ILE A 139 ? O ILE A 135 
AA2 2 3 N LEU A 138 ? N LEU A 134 O LYS A 146 ? O LYS A 142 
AA3 1 2 N LEU A 128 ? N LEU A 124 O ARG A 154 ? O ARG A 150 
AA4 1 2 N GLY C 15  ? N GLY C 11  O VAL C 22  ? O VAL C 18  
AA4 2 3 N ALA C 25  ? N ALA C 21  O VAL C 34  ? O VAL C 30  
AA4 3 4 N ALA C 35  ? N ALA C 31  O PHE C 84  ? O PHE C 80  
AA4 4 5 O VAL C 83  ? O VAL C 79  N LEU C 71  ? N LEU C 67  
AA5 1 2 N GLN C 89  ? N GLN C 85  O ILE C 139 ? O ILE C 135 
AA5 2 3 N LEU C 138 ? N LEU C 134 O LYS C 146 ? O LYS C 142 
AA6 1 2 N LEU C 128 ? N LEU C 124 O ARG C 154 ? O ARG C 150 
# 
_pdbx_entry_details.entry_id                   9ESU 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ALA A 95  ? ? 31.62   -123.60 
2  1 ASP A 127 ? ? -162.80 43.65   
3  1 ASP A 145 ? ? 60.50   86.03   
4  1 VAL A 164 ? ? 79.38   125.96  
5  1 SER A 181 ? ? -141.70 -156.57 
6  1 VAL B 175 ? ? 32.58   65.01   
7  1 TRP B 372 ? ? -28.03  112.25  
8  1 THR C 41  ? ? -128.48 -86.58  
9  1 ASP C 127 ? ? -153.13 45.37   
10 1 ASP C 145 ? ? 47.30   82.34   
11 1 PHE C 146 ? ? -98.62  30.36   
12 1 GLU C 162 ? B -67.48  78.87   
13 1 VAL C 164 ? ? 77.50   127.54  
14 1 ARG C 199 ? ? 59.91   15.28   
15 1 PRO C 228 ? ? -38.12  120.64  
16 1 VAL D 175 ? ? 39.18   62.50   
17 1 GLN D 323 ? ? -162.57 82.59   
18 1 TRP D 372 ? ? -32.95  110.04  
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 157 ? ? 0.173 'SIDE CHAIN' 
2 1 ARG A 200 ? ? 0.289 'SIDE CHAIN' 
3 1 ARG A 217 ? ? 0.104 'SIDE CHAIN' 
4 1 ARG B 293 ? ? 0.164 'SIDE CHAIN' 
5 1 ARG B 410 ? ? 0.084 'SIDE CHAIN' 
6 1 ARG D 250 ? ? 0.219 'SIDE CHAIN' 
7 1 ARG D 293 ? ? 0.237 'SIDE CHAIN' 
# 
loop_
_pdbx_struct_mod_residue.id 
_pdbx_struct_mod_residue.label_asym_id 
_pdbx_struct_mod_residue.label_comp_id 
_pdbx_struct_mod_residue.label_seq_id 
_pdbx_struct_mod_residue.auth_asym_id 
_pdbx_struct_mod_residue.auth_comp_id 
_pdbx_struct_mod_residue.auth_seq_id 
_pdbx_struct_mod_residue.PDB_ins_code 
_pdbx_struct_mod_residue.parent_comp_id 
_pdbx_struct_mod_residue.details 
1 A TPO 164 A TPO 160 ? THR 'modified residue' 
2 C TPO 164 C TPO 160 ? THR 'modified residue' 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? B HOH 650 ? 6.61 . 
2 1 O ? D HOH 586 ? 6.25 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B HIS 433 ? B HIS 263 
2  1 Y 1 B HIS 434 ? B HIS 264 
3  1 Y 1 B HIS 435 ? B HIS 265 
4  1 Y 1 B HIS 436 ? B HIS 266 
5  1 Y 1 B HIS 437 ? B HIS 267 
6  1 Y 1 B HIS 438 ? B HIS 268 
7  1 Y 1 C GLY -3  ? C GLY 1   
8  1 Y 1 C PRO -2  ? C PRO 2   
9  1 Y 1 C ARG 297 ? C ARG 301 
10 1 Y 1 C LEU 298 ? C LEU 302 
11 1 Y 1 D HIS 433 ? D HIS 263 
12 1 Y 1 D HIS 434 ? D HIS 264 
13 1 Y 1 D HIS 435 ? D HIS 265 
14 1 Y 1 D HIS 436 ? D HIS 266 
15 1 Y 1 D HIS 437 ? D HIS 267 
16 1 Y 1 D HIS 438 ? D HIS 268 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
IJU C4   C  Y N 161 
IJU C5   C  Y N 162 
IJU C6   C  Y N 163 
IJU C7   C  Y N 164 
IJU N1   N  Y N 165 
IJU C3   C  Y N 166 
IJU C1   C  N N 167 
IJU O1   O  N N 168 
IJU C2   C  N N 169 
IJU BR1  BR N N 170 
IJU H1   H  N N 171 
IJU H2   H  N N 172 
IJU H3   H  N N 173 
IJU H4   H  N N 174 
IJU H5   H  N N 175 
IJU H6   H  N N 176 
IJU H7   H  N N 177 
IJU H8   H  N N 178 
ILE N    N  N N 179 
ILE CA   C  N S 180 
ILE C    C  N N 181 
ILE O    O  N N 182 
ILE CB   C  N S 183 
ILE CG1  C  N N 184 
ILE CG2  C  N N 185 
ILE CD1  C  N N 186 
ILE OXT  O  N N 187 
ILE H    H  N N 188 
ILE H2   H  N N 189 
ILE HA   H  N N 190 
ILE HB   H  N N 191 
ILE HG12 H  N N 192 
ILE HG13 H  N N 193 
ILE HG21 H  N N 194 
ILE HG22 H  N N 195 
ILE HG23 H  N N 196 
ILE HD11 H  N N 197 
ILE HD12 H  N N 198 
ILE HD13 H  N N 199 
ILE HXT  H  N N 200 
LEU N    N  N N 201 
LEU CA   C  N S 202 
LEU C    C  N N 203 
LEU O    O  N N 204 
LEU CB   C  N N 205 
LEU CG   C  N N 206 
LEU CD1  C  N N 207 
LEU CD2  C  N N 208 
LEU OXT  O  N N 209 
LEU H    H  N N 210 
LEU H2   H  N N 211 
LEU HA   H  N N 212 
LEU HB2  H  N N 213 
LEU HB3  H  N N 214 
LEU HG   H  N N 215 
LEU HD11 H  N N 216 
LEU HD12 H  N N 217 
LEU HD13 H  N N 218 
LEU HD21 H  N N 219 
LEU HD22 H  N N 220 
LEU HD23 H  N N 221 
LEU HXT  H  N N 222 
LYS N    N  N N 223 
LYS CA   C  N S 224 
LYS C    C  N N 225 
LYS O    O  N N 226 
LYS CB   C  N N 227 
LYS CG   C  N N 228 
LYS CD   C  N N 229 
LYS CE   C  N N 230 
LYS NZ   N  N N 231 
LYS OXT  O  N N 232 
LYS H    H  N N 233 
LYS H2   H  N N 234 
LYS HA   H  N N 235 
LYS HB2  H  N N 236 
LYS HB3  H  N N 237 
LYS HG2  H  N N 238 
LYS HG3  H  N N 239 
LYS HD2  H  N N 240 
LYS HD3  H  N N 241 
LYS HE2  H  N N 242 
LYS HE3  H  N N 243 
LYS HZ1  H  N N 244 
LYS HZ2  H  N N 245 
LYS HZ3  H  N N 246 
LYS HXT  H  N N 247 
MET N    N  N N 248 
MET CA   C  N S 249 
MET C    C  N N 250 
MET O    O  N N 251 
MET CB   C  N N 252 
MET CG   C  N N 253 
MET SD   S  N N 254 
MET CE   C  N N 255 
MET OXT  O  N N 256 
MET H    H  N N 257 
MET H2   H  N N 258 
MET HA   H  N N 259 
MET HB2  H  N N 260 
MET HB3  H  N N 261 
MET HG2  H  N N 262 
MET HG3  H  N N 263 
MET HE1  H  N N 264 
MET HE2  H  N N 265 
MET HE3  H  N N 266 
MET HXT  H  N N 267 
PHE N    N  N N 268 
PHE CA   C  N S 269 
PHE C    C  N N 270 
PHE O    O  N N 271 
PHE CB   C  N N 272 
PHE CG   C  Y N 273 
PHE CD1  C  Y N 274 
PHE CD2  C  Y N 275 
PHE CE1  C  Y N 276 
PHE CE2  C  Y N 277 
PHE CZ   C  Y N 278 
PHE OXT  O  N N 279 
PHE H    H  N N 280 
PHE H2   H  N N 281 
PHE HA   H  N N 282 
PHE HB2  H  N N 283 
PHE HB3  H  N N 284 
PHE HD1  H  N N 285 
PHE HD2  H  N N 286 
PHE HE1  H  N N 287 
PHE HE2  H  N N 288 
PHE HZ   H  N N 289 
PHE HXT  H  N N 290 
PRO N    N  N N 291 
PRO CA   C  N S 292 
PRO C    C  N N 293 
PRO O    O  N N 294 
PRO CB   C  N N 295 
PRO CG   C  N N 296 
PRO CD   C  N N 297 
PRO OXT  O  N N 298 
PRO H    H  N N 299 
PRO HA   H  N N 300 
PRO HB2  H  N N 301 
PRO HB3  H  N N 302 
PRO HG2  H  N N 303 
PRO HG3  H  N N 304 
PRO HD2  H  N N 305 
PRO HD3  H  N N 306 
PRO HXT  H  N N 307 
SER N    N  N N 308 
SER CA   C  N S 309 
SER C    C  N N 310 
SER O    O  N N 311 
SER CB   C  N N 312 
SER OG   O  N N 313 
SER OXT  O  N N 314 
SER H    H  N N 315 
SER H2   H  N N 316 
SER HA   H  N N 317 
SER HB2  H  N N 318 
SER HB3  H  N N 319 
SER HG   H  N N 320 
SER HXT  H  N N 321 
THR N    N  N N 322 
THR CA   C  N S 323 
THR C    C  N N 324 
THR O    O  N N 325 
THR CB   C  N R 326 
THR OG1  O  N N 327 
THR CG2  C  N N 328 
THR OXT  O  N N 329 
THR H    H  N N 330 
THR H2   H  N N 331 
THR HA   H  N N 332 
THR HB   H  N N 333 
THR HG1  H  N N 334 
THR HG21 H  N N 335 
THR HG22 H  N N 336 
THR HG23 H  N N 337 
THR HXT  H  N N 338 
TPO N    N  N N 339 
TPO CA   C  N S 340 
TPO CB   C  N R 341 
TPO CG2  C  N N 342 
TPO OG1  O  N N 343 
TPO P    P  N N 344 
TPO O1P  O  N N 345 
TPO O2P  O  N N 346 
TPO O3P  O  N N 347 
TPO C    C  N N 348 
TPO O    O  N N 349 
TPO OXT  O  N N 350 
TPO H    H  N N 351 
TPO H2   H  N N 352 
TPO HA   H  N N 353 
TPO HB   H  N N 354 
TPO HG21 H  N N 355 
TPO HG22 H  N N 356 
TPO HG23 H  N N 357 
TPO HOP2 H  N N 358 
TPO HOP3 H  N N 359 
TPO HXT  H  N N 360 
TRP N    N  N N 361 
TRP CA   C  N S 362 
TRP C    C  N N 363 
TRP O    O  N N 364 
TRP CB   C  N N 365 
TRP CG   C  Y N 366 
TRP CD1  C  Y N 367 
TRP CD2  C  Y N 368 
TRP NE1  N  Y N 369 
TRP CE2  C  Y N 370 
TRP CE3  C  Y N 371 
TRP CZ2  C  Y N 372 
TRP CZ3  C  Y N 373 
TRP CH2  C  Y N 374 
TRP OXT  O  N N 375 
TRP H    H  N N 376 
TRP H2   H  N N 377 
TRP HA   H  N N 378 
TRP HB2  H  N N 379 
TRP HB3  H  N N 380 
TRP HD1  H  N N 381 
TRP HE1  H  N N 382 
TRP HE3  H  N N 383 
TRP HZ2  H  N N 384 
TRP HZ3  H  N N 385 
TRP HH2  H  N N 386 
TRP HXT  H  N N 387 
TYR N    N  N N 388 
TYR CA   C  N S 389 
TYR C    C  N N 390 
TYR O    O  N N 391 
TYR CB   C  N N 392 
TYR CG   C  Y N 393 
TYR CD1  C  Y N 394 
TYR CD2  C  Y N 395 
TYR CE1  C  Y N 396 
TYR CE2  C  Y N 397 
TYR CZ   C  Y N 398 
TYR OH   O  N N 399 
TYR OXT  O  N N 400 
TYR H    H  N N 401 
TYR H2   H  N N 402 
TYR HA   H  N N 403 
TYR HB2  H  N N 404 
TYR HB3  H  N N 405 
TYR HD1  H  N N 406 
TYR HD2  H  N N 407 
TYR HE1  H  N N 408 
TYR HE2  H  N N 409 
TYR HH   H  N N 410 
TYR HXT  H  N N 411 
VAL N    N  N N 412 
VAL CA   C  N S 413 
VAL C    C  N N 414 
VAL O    O  N N 415 
VAL CB   C  N N 416 
VAL CG1  C  N N 417 
VAL CG2  C  N N 418 
VAL OXT  O  N N 419 
VAL H    H  N N 420 
VAL H2   H  N N 421 
VAL HA   H  N N 422 
VAL HB   H  N N 423 
VAL HG11 H  N N 424 
VAL HG12 H  N N 425 
VAL HG13 H  N N 426 
VAL HG21 H  N N 427 
VAL HG22 H  N N 428 
VAL HG23 H  N N 429 
VAL HXT  H  N N 430 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
IJU BR1 C5   sing N N 152 
IJU C6  C7   doub Y N 153 
IJU C6  C5   sing Y N 154 
IJU C7  N1   sing Y N 155 
IJU C5  C4   doub Y N 156 
IJU N1  C3   doub Y N 157 
IJU C4  C3   sing Y N 158 
IJU C3  C2   sing N N 159 
IJU C2  O1   sing N N 160 
IJU O1  C1   sing N N 161 
IJU C4  H1   sing N N 162 
IJU C6  H2   sing N N 163 
IJU C7  H3   sing N N 164 
IJU C1  H4   sing N N 165 
IJU C1  H5   sing N N 166 
IJU C1  H6   sing N N 167 
IJU C2  H7   sing N N 168 
IJU C2  H8   sing N N 169 
ILE N   CA   sing N N 170 
ILE N   H    sing N N 171 
ILE N   H2   sing N N 172 
ILE CA  C    sing N N 173 
ILE CA  CB   sing N N 174 
ILE CA  HA   sing N N 175 
ILE C   O    doub N N 176 
ILE C   OXT  sing N N 177 
ILE CB  CG1  sing N N 178 
ILE CB  CG2  sing N N 179 
ILE CB  HB   sing N N 180 
ILE CG1 CD1  sing N N 181 
ILE CG1 HG12 sing N N 182 
ILE CG1 HG13 sing N N 183 
ILE CG2 HG21 sing N N 184 
ILE CG2 HG22 sing N N 185 
ILE CG2 HG23 sing N N 186 
ILE CD1 HD11 sing N N 187 
ILE CD1 HD12 sing N N 188 
ILE CD1 HD13 sing N N 189 
ILE OXT HXT  sing N N 190 
LEU N   CA   sing N N 191 
LEU N   H    sing N N 192 
LEU N   H2   sing N N 193 
LEU CA  C    sing N N 194 
LEU CA  CB   sing N N 195 
LEU CA  HA   sing N N 196 
LEU C   O    doub N N 197 
LEU C   OXT  sing N N 198 
LEU CB  CG   sing N N 199 
LEU CB  HB2  sing N N 200 
LEU CB  HB3  sing N N 201 
LEU CG  CD1  sing N N 202 
LEU CG  CD2  sing N N 203 
LEU CG  HG   sing N N 204 
LEU CD1 HD11 sing N N 205 
LEU CD1 HD12 sing N N 206 
LEU CD1 HD13 sing N N 207 
LEU CD2 HD21 sing N N 208 
LEU CD2 HD22 sing N N 209 
LEU CD2 HD23 sing N N 210 
LEU OXT HXT  sing N N 211 
LYS N   CA   sing N N 212 
LYS N   H    sing N N 213 
LYS N   H2   sing N N 214 
LYS CA  C    sing N N 215 
LYS CA  CB   sing N N 216 
LYS CA  HA   sing N N 217 
LYS C   O    doub N N 218 
LYS C   OXT  sing N N 219 
LYS CB  CG   sing N N 220 
LYS CB  HB2  sing N N 221 
LYS CB  HB3  sing N N 222 
LYS CG  CD   sing N N 223 
LYS CG  HG2  sing N N 224 
LYS CG  HG3  sing N N 225 
LYS CD  CE   sing N N 226 
LYS CD  HD2  sing N N 227 
LYS CD  HD3  sing N N 228 
LYS CE  NZ   sing N N 229 
LYS CE  HE2  sing N N 230 
LYS CE  HE3  sing N N 231 
LYS NZ  HZ1  sing N N 232 
LYS NZ  HZ2  sing N N 233 
LYS NZ  HZ3  sing N N 234 
LYS OXT HXT  sing N N 235 
MET N   CA   sing N N 236 
MET N   H    sing N N 237 
MET N   H2   sing N N 238 
MET CA  C    sing N N 239 
MET CA  CB   sing N N 240 
MET CA  HA   sing N N 241 
MET C   O    doub N N 242 
MET C   OXT  sing N N 243 
MET CB  CG   sing N N 244 
MET CB  HB2  sing N N 245 
MET CB  HB3  sing N N 246 
MET CG  SD   sing N N 247 
MET CG  HG2  sing N N 248 
MET CG  HG3  sing N N 249 
MET SD  CE   sing N N 250 
MET CE  HE1  sing N N 251 
MET CE  HE2  sing N N 252 
MET CE  HE3  sing N N 253 
MET OXT HXT  sing N N 254 
PHE N   CA   sing N N 255 
PHE N   H    sing N N 256 
PHE N   H2   sing N N 257 
PHE CA  C    sing N N 258 
PHE CA  CB   sing N N 259 
PHE CA  HA   sing N N 260 
PHE C   O    doub N N 261 
PHE C   OXT  sing N N 262 
PHE CB  CG   sing N N 263 
PHE CB  HB2  sing N N 264 
PHE CB  HB3  sing N N 265 
PHE CG  CD1  doub Y N 266 
PHE CG  CD2  sing Y N 267 
PHE CD1 CE1  sing Y N 268 
PHE CD1 HD1  sing N N 269 
PHE CD2 CE2  doub Y N 270 
PHE CD2 HD2  sing N N 271 
PHE CE1 CZ   doub Y N 272 
PHE CE1 HE1  sing N N 273 
PHE CE2 CZ   sing Y N 274 
PHE CE2 HE2  sing N N 275 
PHE CZ  HZ   sing N N 276 
PHE OXT HXT  sing N N 277 
PRO N   CA   sing N N 278 
PRO N   CD   sing N N 279 
PRO N   H    sing N N 280 
PRO CA  C    sing N N 281 
PRO CA  CB   sing N N 282 
PRO CA  HA   sing N N 283 
PRO C   O    doub N N 284 
PRO C   OXT  sing N N 285 
PRO CB  CG   sing N N 286 
PRO CB  HB2  sing N N 287 
PRO CB  HB3  sing N N 288 
PRO CG  CD   sing N N 289 
PRO CG  HG2  sing N N 290 
PRO CG  HG3  sing N N 291 
PRO CD  HD2  sing N N 292 
PRO CD  HD3  sing N N 293 
PRO OXT HXT  sing N N 294 
SER N   CA   sing N N 295 
SER N   H    sing N N 296 
SER N   H2   sing N N 297 
SER CA  C    sing N N 298 
SER CA  CB   sing N N 299 
SER CA  HA   sing N N 300 
SER C   O    doub N N 301 
SER C   OXT  sing N N 302 
SER CB  OG   sing N N 303 
SER CB  HB2  sing N N 304 
SER CB  HB3  sing N N 305 
SER OG  HG   sing N N 306 
SER OXT HXT  sing N N 307 
THR N   CA   sing N N 308 
THR N   H    sing N N 309 
THR N   H2   sing N N 310 
THR CA  C    sing N N 311 
THR CA  CB   sing N N 312 
THR CA  HA   sing N N 313 
THR C   O    doub N N 314 
THR C   OXT  sing N N 315 
THR CB  OG1  sing N N 316 
THR CB  CG2  sing N N 317 
THR CB  HB   sing N N 318 
THR OG1 HG1  sing N N 319 
THR CG2 HG21 sing N N 320 
THR CG2 HG22 sing N N 321 
THR CG2 HG23 sing N N 322 
THR OXT HXT  sing N N 323 
TPO N   CA   sing N N 324 
TPO N   H    sing N N 325 
TPO N   H2   sing N N 326 
TPO CA  CB   sing N N 327 
TPO CA  C    sing N N 328 
TPO CA  HA   sing N N 329 
TPO CB  CG2  sing N N 330 
TPO CB  OG1  sing N N 331 
TPO CB  HB   sing N N 332 
TPO CG2 HG21 sing N N 333 
TPO CG2 HG22 sing N N 334 
TPO CG2 HG23 sing N N 335 
TPO OG1 P    sing N N 336 
TPO P   O1P  doub N N 337 
TPO P   O2P  sing N N 338 
TPO P   O3P  sing N N 339 
TPO O2P HOP2 sing N N 340 
TPO O3P HOP3 sing N N 341 
TPO C   O    doub N N 342 
TPO C   OXT  sing N N 343 
TPO OXT HXT  sing N N 344 
TRP N   CA   sing N N 345 
TRP N   H    sing N N 346 
TRP N   H2   sing N N 347 
TRP CA  C    sing N N 348 
TRP CA  CB   sing N N 349 
TRP CA  HA   sing N N 350 
TRP C   O    doub N N 351 
TRP C   OXT  sing N N 352 
TRP CB  CG   sing N N 353 
TRP CB  HB2  sing N N 354 
TRP CB  HB3  sing N N 355 
TRP CG  CD1  doub Y N 356 
TRP CG  CD2  sing Y N 357 
TRP CD1 NE1  sing Y N 358 
TRP CD1 HD1  sing N N 359 
TRP CD2 CE2  doub Y N 360 
TRP CD2 CE3  sing Y N 361 
TRP NE1 CE2  sing Y N 362 
TRP NE1 HE1  sing N N 363 
TRP CE2 CZ2  sing Y N 364 
TRP CE3 CZ3  doub Y N 365 
TRP CE3 HE3  sing N N 366 
TRP CZ2 CH2  doub Y N 367 
TRP CZ2 HZ2  sing N N 368 
TRP CZ3 CH2  sing Y N 369 
TRP CZ3 HZ3  sing N N 370 
TRP CH2 HH2  sing N N 371 
TRP OXT HXT  sing N N 372 
TYR N   CA   sing N N 373 
TYR N   H    sing N N 374 
TYR N   H2   sing N N 375 
TYR CA  C    sing N N 376 
TYR CA  CB   sing N N 377 
TYR CA  HA   sing N N 378 
TYR C   O    doub N N 379 
TYR C   OXT  sing N N 380 
TYR CB  CG   sing N N 381 
TYR CB  HB2  sing N N 382 
TYR CB  HB3  sing N N 383 
TYR CG  CD1  doub Y N 384 
TYR CG  CD2  sing Y N 385 
TYR CD1 CE1  sing Y N 386 
TYR CD1 HD1  sing N N 387 
TYR CD2 CE2  doub Y N 388 
TYR CD2 HD2  sing N N 389 
TYR CE1 CZ   doub Y N 390 
TYR CE1 HE1  sing N N 391 
TYR CE2 CZ   sing Y N 392 
TYR CE2 HE2  sing N N 393 
TYR CZ  OH   sing N N 394 
TYR OH  HH   sing N N 395 
TYR OXT HXT  sing N N 396 
VAL N   CA   sing N N 397 
VAL N   H    sing N N 398 
VAL N   H2   sing N N 399 
VAL CA  C    sing N N 400 
VAL CA  CB   sing N N 401 
VAL CA  HA   sing N N 402 
VAL C   O    doub N N 403 
VAL C   OXT  sing N N 404 
VAL CB  CG1  sing N N 405 
VAL CB  CG2  sing N N 406 
VAL CB  HB   sing N N 407 
VAL CG1 HG11 sing N N 408 
VAL CG1 HG12 sing N N 409 
VAL CG1 HG13 sing N N 410 
VAL CG2 HG21 sing N N 411 
VAL CG2 HG22 sing N N 412 
VAL CG2 HG23 sing N N 413 
VAL OXT HXT  sing N N 414 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Medical Research Council (MRC, United Kingdom)' 'United Kingdom' MR/N009738/1 1 
'Medical Research Council (MRC, United Kingdom)' 'United Kingdom' MR/V029142/1 2 
'Cancer Research UK'                             'United Kingdom' C2115/A21421 3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6GUC 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9ESU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013490 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007477 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006772 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
BR 35 35 17.1822 2.1723  5.2368 16.5796 5.6388 0.2609  3.9859 41.4328 -0.0527  
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
P  15 15 6.4348  1.9067  4.1793 27.1570 1.7801 0.5260  1.4909 68.1645 1.2466   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0257   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLY A 1 1   ? -19.201 -6.91   25.274  1    85.55  ? -3  GLY A N   1 
ATOM   2    C  CA  . GLY A 1 1   ? -20.48  -6.179  25.198  1    94.5   ? -3  GLY A CA  1 
ATOM   3    C  C   . GLY A 1 1   ? -21.142 -6.11   26.559  1    95.84  ? -3  GLY A C   1 
ATOM   4    O  O   . GLY A 1 1   ? -20.823 -5.177  27.324  1    85.97  ? -3  GLY A O   1 
ATOM   5    N  N   . PRO A 1 2   ? -22.035 -7.06   26.917  1    106.81 ? -2  PRO A N   1 
ATOM   6    C  CA  . PRO A 1 2   ? -22.631 -7.08   28.246  1    108.47 ? -2  PRO A CA  1 
ATOM   7    C  C   . PRO A 1 2   ? -21.693 -7.727  29.252  1    103.62 ? -2  PRO A C   1 
ATOM   8    O  O   . PRO A 1 2   ? -22.145 -8.081  30.36   1    108.11 ? -2  PRO A O   1 
ATOM   9    C  CB  . PRO A 1 2   ? -23.889 -7.918  28.003  1    115.38 ? -2  PRO A CB  1 
ATOM   10   C  CG  . PRO A 1 2   ? -23.449 -8.918  26.96   1    98.8   ? -2  PRO A CG  1 
ATOM   11   C  CD  . PRO A 1 2   ? -22.502 -8.139  26.06   1    103.01 ? -2  PRO A CD  1 
ATOM   12   N  N   . GLY A 1 3   ? -20.418 -7.884  28.882  1    101.34 ? -1  GLY A N   1 
ATOM   13   C  CA  . GLY A 1 3   ? -19.433 -8.525  29.772  1    89.69  ? -1  GLY A CA  1 
ATOM   14   C  C   . GLY A 1 3   ? -18.571 -7.503  30.482  1    84.24  ? -1  GLY A C   1 
ATOM   15   O  O   . GLY A 1 3   ? -18.512 -6.348  30.009  1    91.81  ? -1  GLY A O   1 
ATOM   16   N  N   . SER A 1 4   ? -17.915 -7.912  31.57   1    95.41  ? 0   SER A N   1 
ATOM   17   C  CA  . SER A 1 4   ? -17.057 -7.001  32.365  1    99.39  ? 0   SER A CA  1 
ATOM   18   C  C   . SER A 1 4   ? -15.943 -7.831  33      1    91.54  ? 0   SER A C   1 
ATOM   19   O  O   . SER A 1 4   ? -16.251 -8.895  33.558  1    100.17 ? 0   SER A O   1 
ATOM   20   C  CB  . SER A 1 4   ? -17.848 -6.29   33.413  1    96.15  ? 0   SER A CB  1 
ATOM   21   O  OG  . SER A 1 4   ? -18.368 -7.215  34.358  1    111.61 ? 0   SER A OG  1 
ATOM   22   N  N   . MET A 1 5   ? -14.709 -7.352  32.93   1    78.45  ? 1   MET A N   1 
ATOM   23   C  CA  . MET A 1 5   ? -13.593 -8.142  33.436  1    71.98  ? 1   MET A CA  1 
ATOM   24   C  C   . MET A 1 5   ? -13.733 -8.453  34.924  1    72.28  ? 1   MET A C   1 
ATOM   25   O  O   . MET A 1 5   ? -13.15  -9.417  35.4    1    78.32  ? 1   MET A O   1 
ATOM   26   C  CB  . MET A 1 5   ? -12.252 -7.445  33.225  1    70.49  ? 1   MET A CB  1 
ATOM   27   C  CG  . MET A 1 5   ? -11.887 -7.368  31.783  1    72.86  ? 1   MET A CG  1 
ATOM   28   S  SD  . MET A 1 5   ? -12.25  -8.937  30.978  1    75.33  ? 1   MET A SD  1 
ATOM   29   C  CE  . MET A 1 5   ? -10.853 -9.965  31.461  1    74.06  ? 1   MET A CE  1 
ATOM   30   N  N   . GLU A 1 6   ? -14.534 -7.666  35.644  1    72.21  ? 2   GLU A N   1 
ATOM   31   C  CA  . GLU A 1 6   ? -14.743 -7.869  37.066  1    72.13  ? 2   GLU A CA  1 
ATOM   32   C  C   . GLU A 1 6   ? -15.493 -9.181  37.324  1    67.33  ? 2   GLU A C   1 
ATOM   33   O  O   . GLU A 1 6   ? -15.414 -9.761  38.38   1    65.55  ? 2   GLU A O   1 
ATOM   34   C  CB  . GLU A 1 6   ? -15.394 -6.598  37.613  1    81.01  ? 2   GLU A CB  1 
ATOM   35   C  CG  . GLU A 1 6   ? -15.036 -6.311  39.071  1    97.09  ? 2   GLU A CG  1 
ATOM   36   C  CD  . GLU A 1 6   ? -15.899 -7.006  40.121  1    119.39 ? 2   GLU A CD  1 
ATOM   37   O  OE1 . GLU A 1 6   ? -15.328 -7.806  40.913  1    127.96 ? 2   GLU A OE1 1 
ATOM   38   O  OE2 . GLU A 1 6   ? -17.139 -6.753  40.165  1    128.32 ? 2   GLU A OE2 1 
ATOM   39   N  N   . ASN A 1 7   ? -16.179 -9.697  36.308  1    68.36  ? 3   ASN A N   1 
ATOM   40   C  CA  . ASN A 1 7   ? -16.958 -10.956 36.477  1    66.48  ? 3   ASN A CA  1 
ATOM   41   C  C   . ASN A 1 7   ? -16.056 -12.179 36.29   1    63.54  ? 3   ASN A C   1 
ATOM   42   O  O   . ASN A 1 7   ? -16.518 -13.297 36.555  1    63.03  ? 3   ASN A O   1 
ATOM   43   C  CB  . ASN A 1 7   ? -18.142 -11.035 35.525  1    67.91  ? 3   ASN A CB  1 
ATOM   44   C  CG  . ASN A 1 7   ? -19.145 -9.934  35.762  1    71.8   ? 3   ASN A CG  1 
ATOM   45   O  OD1 . ASN A 1 7   ? -19.379 -9.549  36.911  1    79.53  ? 3   ASN A OD1 1 
ATOM   46   N  ND2 . ASN A 1 7   ? -19.745 -9.421  34.699  1    68.77  ? 3   ASN A ND2 1 
ATOM   47   N  N   . PHE A 1 8   ? -14.825 -11.969 35.838  1    58.85  ? 4   PHE A N   1 
ATOM   48   C  CA  . PHE A 1 8   ? -13.933 -13.096 35.608  1    56.79  ? 4   PHE A CA  1 
ATOM   49   C  C   . PHE A 1 8   ? -12.813 -13.169 36.653  1    63.2   ? 4   PHE A C   1 
ATOM   50   O  O   . PHE A 1 8   ? -12.333 -12.155 37.157  1    74.81  ? 4   PHE A O   1 
ATOM   51   C  CB  . PHE A 1 8   ? -13.395 -13.071 34.191  1    55.26  ? 4   PHE A CB  1 
ATOM   52   C  CG  . PHE A 1 8   ? -14.463 -13.169 33.12   1    54.11  ? 4   PHE A CG  1 
ATOM   53   C  CD1 . PHE A 1 8   ? -15.016 -14.403 32.806  1    52.34  ? 4   PHE A CD1 1 
ATOM   54   C  CD2 . PHE A 1 8   ? -14.91  -12.033 32.432  1    54.03  ? 4   PHE A CD2 1 
ATOM   55   C  CE1 . PHE A 1 8   ? -15.999 -14.507 31.822  1    52.73  ? 4   PHE A CE1 1 
ATOM   56   C  CE2 . PHE A 1 8   ? -15.899 -12.142 31.464  1    53.81  ? 4   PHE A CE2 1 
ATOM   57   C  CZ  . PHE A 1 8   ? -16.441 -13.38  31.148  1    52.36  ? 4   PHE A CZ  1 
ATOM   58   N  N   . GLN A 1 9   ? -12.474 -14.4   37.039  1    61.02  ? 5   GLN A N   1 
ATOM   59   C  CA  . GLN A 1 9   ? -11.3   -14.733 37.823  1    61.21  ? 5   GLN A CA  1 
ATOM   60   C  C   . GLN A 1 9   ? -10.388 -15.58  36.943  1    60.18  ? 5   GLN A C   1 
ATOM   61   O  O   . GLN A 1 9   ? -10.785 -16.67  36.542  1    58.83  ? 5   GLN A O   1 
ATOM   62   C  CB  . GLN A 1 9   ? -11.72  -15.585 39.023  1    65.71  ? 5   GLN A CB  1 
ATOM   63   C  CG  . GLN A 1 9   ? -10.578 -16.03  39.931  1    70.35  ? 5   GLN A CG  1 
ATOM   64   C  CD  . GLN A 1 9   ? -9.904  -14.848 40.59   1    80.39  ? 5   GLN A CD  1 
ATOM   65   O  OE1 . GLN A 1 9   ? -10.556 -13.869 40.996  1    89.05  ? 5   GLN A OE1 1 
ATOM   66   N  NE2 . GLN A 1 9   ? -8.583  -14.918 40.675  1    82.57  ? 5   GLN A NE2 1 
ATOM   67   N  N   . LYS A 1 10  ? -9.192  -15.065 36.614  1    61.73  ? 6   LYS A N   1 
ATOM   68   C  CA  . LYS A 1 10  ? -8.205  -15.829 35.863  1    60.84  ? 6   LYS A CA  1 
ATOM   69   C  C   . LYS A 1 10  ? -7.766  -17.047 36.677  1    60.28  ? 6   LYS A C   1 
ATOM   70   O  O   . LYS A 1 10  ? -7.853  -17.016 37.895  1    57.24  ? 6   LYS A O   1 
ATOM   71   C  CB  . LYS A 1 10  ? -6.997  -14.971 35.498  1    63.53  ? 6   LYS A CB  1 
ATOM   72   C  CG  . LYS A 1 10  ? -7.254  -13.876 34.48   1    69.35  ? 6   LYS A CG  1 
ATOM   73   C  CD  . LYS A 1 10  ? -5.968  -13.106 34.179  1    81.74  ? 6   LYS A CD  1 
ATOM   74   C  CE  . LYS A 1 10  ? -6.017  -12.309 32.902  1    89.62  ? 6   LYS A CE  1 
ATOM   75   N  NZ  . LYS A 1 10  ? -6.796  -11.076 33.067  1    93.84  ? 6   LYS A NZ  1 
ATOM   76   N  N   . VAL A 1 11  ? -7.351  -18.121 35.976  1    62.37  ? 7   VAL A N   1 
ATOM   77   C  CA  . VAL A 1 11  ? -7.025  -19.401 36.593  1    65.87  ? 7   VAL A CA  1 
ATOM   78   C  C   . VAL A 1 11  ? -5.583  -19.801 36.284  1    67.76  ? 7   VAL A C   1 
ATOM   79   O  O   . VAL A 1 11  ? -4.893  -20.217 37.21   1    73.82  ? 7   VAL A O   1 
ATOM   80   C  CB  . VAL A 1 11  ? -8.018  -20.528 36.245  1    63.68  ? 7   VAL A CB  1 
ATOM   81   C  CG1 . VAL A 1 11  ? -7.502  -21.907 36.649  1    62.18  ? 7   VAL A CG1 1 
ATOM   82   C  CG2 . VAL A 1 11  ? -9.393  -20.283 36.85   1    61.68  ? 7   VAL A CG2 1 
ATOM   83   N  N   . GLU A 1 12  ? -5.17   -19.692 35.004  1    66.24  ? 8   GLU A N   1 
ATOM   84   C  CA  . GLU A 1 12  ? -3.789  -19.895 34.58   1    69.97  ? 8   GLU A CA  1 
ATOM   85   C  C   . GLU A 1 12  ? -3.643  -19.426 33.133  1    71.99  ? 8   GLU A C   1 
ATOM   86   O  O   . GLU A 1 12  ? -4.649  -19.254 32.443  1    71.2   ? 8   GLU A O   1 
ATOM   87   C  CB  . GLU A 1 12  ? -3.364  -21.362 34.716  1    73.6   ? 8   GLU A CB  1 
ATOM   88   C  CG  . GLU A 1 12  ? -4.112  -22.281 33.756  1    77.9   ? 8   GLU A CG  1 
ATOM   89   C  CD  . GLU A 1 12  ? -4.228  -23.751 34.089  1    76.1   ? 8   GLU A CD  1 
ATOM   90   O  OE1 . GLU A 1 12  ? -4.672  -24.002 35.22   1    88.75  ? 8   GLU A OE1 1 
ATOM   91   O  OE2 . GLU A 1 12  ? -3.943  -24.605 33.232  1    68.42  ? 8   GLU A OE2 1 
ATOM   92   N  N   . LYS A 1 13  ? -2.386  -19.186 32.7    1    70.9   ? 9   LYS A N   1 
ATOM   93   C  CA  . LYS A 1 13  ? -2.046  -18.993 31.299  1    66.91  ? 9   LYS A CA  1 
ATOM   94   C  C   . LYS A 1 13  ? -2.268  -20.325 30.577  1    65.01  ? 9   LYS A C   1 
ATOM   95   O  O   . LYS A 1 13  ? -2.148  -21.371 31.207  1    71.72  ? 9   LYS A O   1 
ATOM   96   C  CB  . LYS A 1 13  ? -0.609  -18.474 31.192  1    69.57  ? 9   LYS A CB  1 
ATOM   97   C  CG  . LYS A 1 13  ? -0.246  -17.928 29.808  1    81.88  ? 9   LYS A CG  1 
ATOM   98   C  CD  . LYS A 1 13  ? 1.201   -17.471 29.596  1    87.76  ? 9   LYS A CD  1 
ATOM   99   C  CE  . LYS A 1 13  ? 1.404   -17.153 28.123  1    109.18 ? 9   LYS A CE  1 
ATOM   100  N  NZ  . LYS A 1 13  ? 2.815   -17.005 27.75   1    128.59 ? 9   LYS A NZ  1 
ATOM   101  N  N   . ILE A 1 14  ? -2.643  -20.297 29.292  1    55.13  ? 10  ILE A N   1 
ATOM   102  C  CA  . ILE A 1 14  ? -2.848  -21.54  28.571  1    54.33  ? 10  ILE A CA  1 
ATOM   103  C  C   . ILE A 1 14  ? -2.224  -21.497 27.184  1    56.52  ? 10  ILE A C   1 
ATOM   104  O  O   . ILE A 1 14  ? -2.064  -22.542 26.55   1    63.03  ? 10  ILE A O   1 
ATOM   105  C  CB  . ILE A 1 14  ? -4.323  -21.955 28.49   1    53.84  ? 10  ILE A CB  1 
ATOM   106  C  CG1 . ILE A 1 14  ? -5.215  -20.871 27.878  1    53.86  ? 10  ILE A CG1 1 
ATOM   107  C  CG2 . ILE A 1 14  ? -4.796  -22.413 29.869  1    55.66  ? 10  ILE A CG2 1 
ATOM   108  C  CD1 . ILE A 1 14  ? -6.669  -21.278 27.7    1    50.11  ? 10  ILE A CD1 1 
ATOM   109  N  N   . GLY A 1 15  ? -1.854  -20.294 26.742  1    59.42  ? 11  GLY A N   1 
ATOM   110  C  CA  . GLY A 1 15  ? -1.29   -20.131 25.415  1    63.96  ? 11  GLY A CA  1 
ATOM   111  C  C   . GLY A 1 15  ? -0.774  -18.715 25.225  1    67.9   ? 11  GLY A C   1 
ATOM   112  O  O   . GLY A 1 15  ? -1.067  -17.824 26.023  1    71.74  ? 11  GLY A O   1 
ATOM   113  N  N   . GLU A 1 16  ? -0.044  -18.525 24.127  1    73.68  ? 12  GLU A N   1 
ATOM   114  C  CA  . GLU A 1 16  ? 0.35    -17.192 23.728  1    84.81  ? 12  GLU A CA  1 
ATOM   115  C  C   . GLU A 1 16  ? 0.495   -17.186 22.213  1    92.17  ? 12  GLU A C   1 
ATOM   116  O  O   . GLU A 1 16  ? 0.473   -18.247 21.594  1    90.63  ? 12  GLU A O   1 
ATOM   117  C  CB  . GLU A 1 16  ? 1.629   -16.812 24.474  1    84.72  ? 12  GLU A CB  1 
ATOM   118  C  CG  . GLU A 1 16  ? 2.099   -15.391 24.184  1    106.72 ? 12  GLU A CG  1 
ATOM   119  C  CD  . GLU A 1 16  ? 3.349   -15.064 24.998  1    119.42 ? 12  GLU A CD  1 
ATOM   120  O  OE1 . GLU A 1 16  ? 3.86    -15.951 25.747  1    113.78 ? 12  GLU A OE1 1 
ATOM   121  O  OE2 . GLU A 1 16  ? 3.803   -13.892 24.893  1    119.79 ? 12  GLU A OE2 1 
ATOM   122  N  N   . GLY A 1 17  ? 0.609   -15.982 21.643  1    110.19 ? 13  GLY A N   1 
ATOM   123  C  CA  . GLY A 1 17  ? 0.874   -15.791 20.225  1    126.77 ? 13  GLY A CA  1 
ATOM   124  C  C   . GLY A 1 17  ? 1.17    -14.32  19.962  1    137.42 ? 13  GLY A C   1 
ATOM   125  O  O   . GLY A 1 17  ? 1.203   -13.541 20.916  1    156.68 ? 13  GLY A O   1 
ATOM   126  N  N   . THR A 1 18  ? 1.377   -13.94  18.688  1    120.87 ? 14  THR A N   1 
ATOM   127  C  CA  . THR A 1 18  ? 1.547   -12.524 18.387  1    116.74 ? 14  THR A CA  1 
ATOM   128  C  C   . THR A 1 18  ? 0.225   -11.835 18.707  1    120.51 ? 14  THR A C   1 
ATOM   129  O  O   . THR A 1 18  ? 0.207   -10.67  19.104  1    123.07 ? 14  THR A O   1 
ATOM   130  C  CB  . THR A 1 18  ? 2.034   -12.242 16.966  1    124.23 ? 14  THR A CB  1 
ATOM   131  O  OG1 . THR A 1 18  ? 1.076   -12.796 16.066  1    123.31 ? 14  THR A OG1 1 
ATOM   132  C  CG2 . THR A 1 18  ? 3.432   -12.794 16.72   1    120.29 ? 14  THR A CG2 1 
ATOM   133  N  N   . TYR A 1 19  ? -0.861  -12.62  18.632  1    118.86 ? 15  TYR A N   1 
ATOM   134  C  CA  . TYR A 1 19  ? -2.173  -12.206 19.114  1    114.09 ? 15  TYR A CA  1 
ATOM   135  C  C   . TYR A 1 19  ? -2.079  -11.726 20.563  1    110.87 ? 15  TYR A C   1 
ATOM   136  O  O   . TYR A 1 19  ? -2.691  -10.72  20.906  1    123.63 ? 15  TYR A O   1 
ATOM   137  C  CB  . TYR A 1 19  ? -3.198  -13.337 19.026  1    130.38 ? 15  TYR A CB  1 
ATOM   138  C  CG  . TYR A 1 19  ? -2.91   -14.381 17.955  1    154.77 ? 15  TYR A CG  1 
ATOM   139  C  CD1 . TYR A 1 19  ? -2.738  -14.028 16.616  1    158    ? 15  TYR A CD1 1 
ATOM   140  C  CD2 . TYR A 1 19  ? -2.796  -15.726 18.29   1    154.9  ? 15  TYR A CD2 1 
ATOM   141  C  CE1 . TYR A 1 19  ? -2.479  -14.982 15.642  1    164.04 ? 15  TYR A CE1 1 
ATOM   142  C  CE2 . TYR A 1 19  ? -2.511  -16.685 17.329  1    165.85 ? 15  TYR A CE2 1 
ATOM   143  C  CZ  . TYR A 1 19  ? -2.363  -16.318 15.997  1    170.26 ? 15  TYR A CZ  1 
ATOM   144  O  OH  . TYR A 1 19  ? -2.101  -17.25  15.019  1    141.81 ? 15  TYR A OH  1 
ATOM   145  N  N   . GLY A 1 20  ? -1.315  -12.435 21.412  1    105.28 ? 16  GLY A N   1 
ATOM   146  C  CA  . GLY A 1 20  ? -1.111  -12.049 22.808  1    80.79  ? 16  GLY A CA  1 
ATOM   147  C  C   . GLY A 1 20  ? -1.181  -13.27  23.724  1    74.71  ? 16  GLY A C   1 
ATOM   148  O  O   . GLY A 1 20  ? -0.856  -14.374 23.294  1    79.41  ? 16  GLY A O   1 
ATOM   149  N  N   . VAL A 1 21  ? -1.648  -13.078 24.966  1    70.28  ? 17  VAL A N   1 
ATOM   150  C  CA  . VAL A 1 21  ? -1.749  -14.157 25.949  1    69.66  ? 17  VAL A CA  1 
ATOM   151  C  C   . VAL A 1 21  ? -3.181  -14.709 26.023  1    62.67  ? 17  VAL A C   1 
ATOM   152  O  O   . VAL A 1 21  ? -4.124  -13.948 25.95   1    65.55  ? 17  VAL A O   1 
ATOM   153  C  CB  . VAL A 1 21  ? -1.248  -13.692 27.336  1    70.77  ? 17  VAL A CB  1 
ATOM   154  C  CG1 . VAL A 1 21  ? -1.935  -12.433 27.847  1    82.29  ? 17  VAL A CG1 1 
ATOM   155  C  CG2 . VAL A 1 21  ? -1.392  -14.76  28.407  1    72.6   ? 17  VAL A CG2 1 
ATOM   156  N  N   . VAL A 1 22  ? -3.352  -16.023 26.219  1    55.6   ? 18  VAL A N   1 
ATOM   157  C  CA  . VAL A 1 22  ? -4.656  -16.599 26.516  1    49.24  ? 18  VAL A CA  1 
ATOM   158  C  C   . VAL A 1 22  ? -4.679  -17.184 27.932  1    53     ? 18  VAL A C   1 
ATOM   159  O  O   . VAL A 1 22  ? -3.824  -17.987 28.291  1    58.14  ? 18  VAL A O   1 
ATOM   160  C  CB  . VAL A 1 22  ? -5.024  -17.643 25.454  1    46.98  ? 18  VAL A CB  1 
ATOM   161  C  CG1 . VAL A 1 22  ? -6.425  -18.203 25.666  1    46.43  ? 18  VAL A CG1 1 
ATOM   162  C  CG2 . VAL A 1 22  ? -4.929  -17.056 24.049  1    46.55  ? 18  VAL A CG2 1 
ATOM   163  N  N   . TYR A 1 23  ? -5.653  -16.771 28.75   1    53.71  ? 19  TYR A N   1 
ATOM   164  C  CA  . TYR A 1 23  ? -5.843  -17.328 30.08   1    58.28  ? 19  TYR A CA  1 
ATOM   165  C  C   . TYR A 1 23  ? -7.117  -18.167 30.145  1    58.79  ? 19  TYR A C   1 
ATOM   166  O  O   . TYR A 1 23  ? -8.14   -17.827 29.56   1    61.51  ? 19  TYR A O   1 
ATOM   167  C  CB  . TYR A 1 23  ? -5.997  -16.268 31.168  1    65.23  ? 19  TYR A CB  1 
ATOM   168  C  CG  . TYR A 1 23  ? -4.84   -15.291 31.323  1    80.19  ? 19  TYR A CG  1 
ATOM   169  C  CD1 . TYR A 1 23  ? -4.696  -14.227 30.432  1    88.31  ? 19  TYR A CD1 1 
ATOM   170  C  CD2 . TYR A 1 23  ? -3.919  -15.412 32.366  1    83.42  ? 19  TYR A CD2 1 
ATOM   171  C  CE1 . TYR A 1 23  ? -3.655  -13.321 30.557  1    94.92  ? 19  TYR A CE1 1 
ATOM   172  C  CE2 . TYR A 1 23  ? -2.872  -14.511 32.498  1    97.05  ? 19  TYR A CE2 1 
ATOM   173  C  CZ  . TYR A 1 23  ? -2.737  -13.47  31.585  1    107.89 ? 19  TYR A CZ  1 
ATOM   174  O  OH  . TYR A 1 23  ? -1.723  -12.557 31.692  1    119.53 ? 19  TYR A OH  1 
ATOM   175  N  N   . LYS A 1 24  ? -7.057  -19.278 30.881  1    56.98  ? 20  LYS A N   1 
ATOM   176  C  CA  . LYS A 1 24  ? -8.275  -19.931 31.324  1    52.92  ? 20  LYS A CA  1 
ATOM   177  C  C   . LYS A 1 24  ? -8.858  -19.121 32.482  1    53.48  ? 20  LYS A C   1 
ATOM   178  O  O   . LYS A 1 24  ? -8.13   -18.65  33.357  1    53.82  ? 20  LYS A O   1 
ATOM   179  C  CB  . LYS A 1 24  ? -7.975  -21.387 31.688  1    53.71  ? 20  LYS A CB  1 
ATOM   180  C  CG  . LYS A 1 24  ? -9.093  -22.133 32.39   1    54.06  ? 20  LYS A CG  1 
ATOM   181  C  CD  . LYS A 1 24  ? -8.611  -23.473 32.929  1    53.92  ? 20  LYS A CD  1 
ATOM   182  C  CE  . LYS A 1 24  ? -9.758  -24.255 33.457  1    54.67  ? 20  LYS A CE  1 
ATOM   183  N  NZ  . LYS A 1 24  ? -9.366  -25.628 33.757  1    56.18  ? 20  LYS A NZ  1 
ATOM   184  N  N   . ALA A 1 25  ? -10.179 -18.942 32.475  1    51.36  ? 21  ALA A N   1 
ATOM   185  C  CA  . ALA A 1 25  ? -10.826 -18.101 33.471  1    51.45  ? 21  ALA A CA  1 
ATOM   186  C  C   . ALA A 1 25  ? -12.208 -18.666 33.782  1    52.04  ? 21  ALA A C   1 
ATOM   187  O  O   . ALA A 1 25  ? -12.746 -19.49  33.03   1    52.41  ? 21  ALA A O   1 
ATOM   188  C  CB  . ALA A 1 25  ? -10.928 -16.698 32.943  1    48.8   ? 21  ALA A CB  1 
ATOM   189  N  N   . ARG A 1 26  ? -12.775 -18.161 34.867  1    52.2   ? 22  ARG A N   1 
ATOM   190  C  CA  . ARG A 1 26  ? -14.047 -18.602 35.403  1    56.87  ? 22  ARG A CA  1 
ATOM   191  C  C   . ARG A 1 26  ? -14.963 -17.379 35.579  1    58.02  ? 22  ARG A C   1 
ATOM   192  O  O   . ARG A 1 26  ? -14.562 -16.362 36.15   1    54.05  ? 22  ARG A O   1 
ATOM   193  C  CB  . ARG A 1 26  ? -13.749 -19.279 36.748  1    62.01  ? 22  ARG A CB  1 
ATOM   194  C  CG  . ARG A 1 26  ? -14.93  -19.959 37.423  1    70.65  ? 22  ARG A CG  1 
ATOM   195  C  CD  . ARG A 1 26  ? -14.503 -20.61  38.728  1    81.93  ? 22  ARG A CD  1 
ATOM   196  N  NE  . ARG A 1 26  ? -14.57  -19.646 39.839  1    96.47  ? 22  ARG A NE  1 
ATOM   197  C  CZ  . ARG A 1 26  ? -13.53  -19.201 40.555  1    98.6   ? 22  ARG A CZ  1 
ATOM   198  N  NH1 . ARG A 1 26  ? -12.314 -19.676 40.296  1    93.27  ? 22  ARG A NH1 1 
ATOM   199  N  NH2 . ARG A 1 26  ? -13.717 -18.301 41.523  1    91.99  ? 22  ARG A NH2 1 
ATOM   200  N  N   . ASN A 1 27  ? -16.201 -17.48  35.062  1    56.47  ? 23  ASN A N   1 
ATOM   201  C  CA  . ASN A 1 27  ? -17.218 -16.456 35.251  1    52.24  ? 23  ASN A CA  1 
ATOM   202  C  C   . ASN A 1 27  ? -17.757 -16.6   36.667  1    54.33  ? 23  ASN A C   1 
ATOM   203  O  O   . ASN A 1 27  ? -18.387 -17.604 36.97   1    56.84  ? 23  ASN A O   1 
ATOM   204  C  CB  . ASN A 1 27  ? -18.311 -16.609 34.195  1    47.06  ? 23  ASN A CB  1 
ATOM   205  C  CG  . ASN A 1 27  ? -19.427 -15.601 34.343  1    46.76  ? 23  ASN A CG  1 
ATOM   206  O  OD1 . ASN A 1 27  ? -19.862 -15.295 35.463  1    49.54  ? 23  ASN A OD1 1 
ATOM   207  N  ND2 . ASN A 1 27  ? -19.937 -15.1   33.233  1    44     ? 23  ASN A ND2 1 
ATOM   208  N  N   . LYS A 1 28  ? -17.554 -15.591 37.52   1    56.74  ? 24  LYS A N   1 
ATOM   209  C  CA  . LYS A 1 28  ? -17.76  -15.776 38.949  1    58.73  ? 24  LYS A CA  1 
ATOM   210  C  C   . LYS A 1 28  ? -19.244 -15.797 39.288  1    57.65  ? 24  LYS A C   1 
ATOM   211  O  O   . LYS A 1 28  ? -19.604 -16.125 40.41   1    57.3   ? 24  LYS A O   1 
ATOM   212  C  CB  . LYS A 1 28  ? -17.071 -14.658 39.73   1    66.59  ? 24  LYS A CB  1 
ATOM   213  C  CG  . LYS A 1 28  ? -15.595 -14.874 40.026  1    78.08  ? 24  LYS A CG  1 
ATOM   214  C  CD  . LYS A 1 28  ? -14.979 -13.705 40.816  1    89.66  ? 24  LYS A CD  1 
ATOM   215  C  CE  . LYS A 1 28  ? -14.268 -12.692 39.923  1    92.76  ? 24  LYS A CE  1 
ATOM   216  N  NZ  . LYS A 1 28  ? -13.932 -11.459 40.647  1    87.3   ? 24  LYS A NZ  1 
ATOM   217  N  N   . LEU A 1 29  ? -20.097 -15.45  38.312  1    59.79  ? 25  LEU A N   1 
ATOM   218  C  CA  . LEU A 1 29  ? -21.543 -15.352 38.543  1    58.9   ? 25  LEU A CA  1 
ATOM   219  C  C   . LEU A 1 29  ? -22.301 -16.566 37.981  1    57.5   ? 25  LEU A C   1 
ATOM   220  O  O   . LEU A 1 29  ? -23.236 -17.029 38.643  1    59.52  ? 25  LEU A O   1 
ATOM   221  C  CB  . LEU A 1 29  ? -22.063 -14.041 37.962  1    55.11  ? 25  LEU A CB  1 
ATOM   222  C  CG  . LEU A 1 29  ? -21.689 -12.777 38.746  1    55.29  ? 25  LEU A CG  1 
ATOM   223  C  CD1 . LEU A 1 29  ? -22.238 -11.536 38.069  1    53.84  ? 25  LEU A CD1 1 
ATOM   224  C  CD2 . LEU A 1 29  ? -22.193 -12.85  40.169  1    56.47  ? 25  LEU A CD2 1 
ATOM   225  N  N   . THR A 1 30  ? -21.879 -17.067 36.806  1    48.91  ? 26  THR A N   1 
ATOM   226  C  CA  . THR A 1 30  ? -22.554 -18.163 36.13   1    49.9   ? 26  THR A CA  1 
ATOM   227  C  C   . THR A 1 30  ? -21.855 -19.502 36.363  1    53.21  ? 26  THR A C   1 
ATOM   228  O  O   . THR A 1 30  ? -22.517 -20.538 36.34   1    57.24  ? 26  THR A O   1 
ATOM   229  C  CB  . THR A 1 30  ? -22.708 -17.93  34.623  1    44.12  ? 26  THR A CB  1 
ATOM   230  O  OG1 . THR A 1 30  ? -21.408 -17.908 34.044  1    41.44  ? 26  THR A OG1 1 
ATOM   231  C  CG2 . THR A 1 30  ? -23.479 -16.664 34.319  1    43.11  ? 26  THR A CG2 1 
ATOM   232  N  N   . GLY A 1 31  ? -20.522 -19.481 36.509  1    54.22  ? 27  GLY A N   1 
ATOM   233  C  CA  . GLY A 1 31  ? -19.709 -20.662 36.771  1    51.95  ? 27  GLY A CA  1 
ATOM   234  C  C   . GLY A 1 31  ? -18.923 -21.083 35.533  1    48.76  ? 27  GLY A C   1 
ATOM   235  O  O   . GLY A 1 31  ? -18.079 -21.976 35.597  1    53.08  ? 27  GLY A O   1 
ATOM   236  N  N   . GLU A 1 32  ? -19.194 -20.409 34.423  1    45.62  ? 28  GLU A N   1 
ATOM   237  C  CA  . GLU A 1 32  ? -18.724 -20.823 33.104  1    45.64  ? 28  GLU A CA  1 
ATOM   238  C  C   . GLU A 1 32  ? -17.207 -20.65  33.019  1    47.84  ? 28  GLU A C   1 
ATOM   239  O  O   . GLU A 1 32  ? -16.674 -19.613 33.415  1    51.61  ? 28  GLU A O   1 
ATOM   240  C  CB  . GLU A 1 32  ? -19.471 -20.026 32.028  1    41.47  ? 28  GLU A CB  1 
ATOM   241  C  CG  . GLU A 1 32  ? -19.132 -20.493 30.628  1    40.35  ? 28  GLU A CG  1 
ATOM   242  C  CD  . GLU A 1 32  ? -19.837 -19.777 29.495  1    42.85  ? 28  GLU A CD  1 
ATOM   243  O  OE1 . GLU A 1 32  ? -20.457 -18.695 29.631  1    42.14  ? 28  GLU A OE1 1 
ATOM   244  O  OE2 . GLU A 1 32  ? -19.74  -20.363 28.396  1    53.43  ? 28  GLU A OE2 1 
ATOM   245  N  N   . VAL A 1 33  ? -16.521 -21.702 32.563  1    45.46  ? 29  VAL A N   1 
ATOM   246  C  CA  . VAL A 1 33  ? -15.099 -21.654 32.267  1    43.16  ? 29  VAL A CA  1 
ATOM   247  C  C   . VAL A 1 33  ? -14.953 -21.162 30.842  1    42.35  ? 29  VAL A C   1 
ATOM   248  O  O   . VAL A 1 33  ? -15.647 -21.641 29.96   1    40.38  ? 29  VAL A O   1 
ATOM   249  C  CB  . VAL A 1 33  ? -14.468 -23.049 32.456  1    43.33  ? 29  VAL A CB  1 
ATOM   250  C  CG1 . VAL A 1 33  ? -12.984 -23.047 32.147  1    45.75  ? 29  VAL A CG1 1 
ATOM   251  C  CG2 . VAL A 1 33  ? -14.66  -23.56  33.883  1    45.95  ? 29  VAL A CG2 1 
ATOM   252  N  N   . VAL A 1 34  ? -14.031 -20.222 30.63   1    45.08  ? 30  VAL A N   1 
ATOM   253  C  CA  . VAL A 1 34  ? -13.84  -19.554 29.343  1    42.7   ? 30  VAL A CA  1 
ATOM   254  C  C   . VAL A 1 34  ? -12.338 -19.432 29.101  1    43.7   ? 30  VAL A C   1 
ATOM   255  O  O   . VAL A 1 34  ? -11.555 -19.555 30.038  1    47.23  ? 30  VAL A O   1 
ATOM   256  C  CB  . VAL A 1 34  ? -14.508 -18.155 29.354  1    43.77  ? 30  VAL A CB  1 
ATOM   257  C  CG1 . VAL A 1 34  ? -16.008 -18.239 29.639  1    43.58  ? 30  VAL A CG1 1 
ATOM   258  C  CG2 . VAL A 1 34  ? -13.883 -17.233 30.399  1    43.24  ? 30  VAL A CG2 1 
ATOM   259  N  N   . ALA A 1 35  ? -11.947 -19.227 27.842  1    43.93  ? 31  ALA A N   1 
ATOM   260  C  CA  . ALA A 1 35  ? -10.615 -18.782 27.474  1    43.17  ? 31  ALA A CA  1 
ATOM   261  C  C   . ALA A 1 35  ? -10.743 -17.296 27.172  1    45.63  ? 31  ALA A C   1 
ATOM   262  O  O   . ALA A 1 35  ? -11.595 -16.978 26.333  1    46.27  ? 31  ALA A O   1 
ATOM   263  C  CB  . ALA A 1 35  ? -10.155 -19.501 26.217  1    38.1   ? 31  ALA A CB  1 
ATOM   264  N  N   . LEU A 1 36  ? -9.92   -16.443 27.82   1    44.64  ? 32  LEU A N   1 
ATOM   265  C  CA  . LEU A 1 36  ? -9.796  -15.028 27.498  1    45.67  ? 32  LEU A CA  1 
ATOM   266  C  C   . LEU A 1 36  ? -8.586  -14.809 26.601  1    48.31  ? 32  LEU A C   1 
ATOM   267  O  O   . LEU A 1 36  ? -7.478  -15.041 27.048  1    55.58  ? 32  LEU A O   1 
ATOM   268  C  CB  . LEU A 1 36  ? -9.57   -14.237 28.77   1    46.87  ? 32  LEU A CB  1 
ATOM   269  C  CG  . LEU A 1 36  ? -10.624 -14.333 29.873  1    51.59  ? 32  LEU A CG  1 
ATOM   270  C  CD1 . LEU A 1 36  ? -10.182 -13.528 31.098  1    51.64  ? 32  LEU A CD1 1 
ATOM   271  C  CD2 . LEU A 1 36  ? -11.98  -13.838 29.41   1    52.94  ? 32  LEU A CD2 1 
ATOM   272  N  N   . LYS A 1 37  ? -8.782  -14.368 25.353  1    47.87  ? 33  LYS A N   1 
ATOM   273  C  CA  . LYS A 1 37  ? -7.685  -13.919 24.51   1    52.35  ? 33  LYS A CA  1 
ATOM   274  C  C   . LYS A 1 37  ? -7.577  -12.411 24.72   1    59.21  ? 33  LYS A C   1 
ATOM   275  O  O   . LYS A 1 37  ? -8.511  -11.689 24.388  1    69.39  ? 33  LYS A O   1 
ATOM   276  C  CB  . LYS A 1 37  ? -7.93   -14.314 23.041  1    55.23  ? 33  LYS A CB  1 
ATOM   277  C  CG  . LYS A 1 37  ? -6.784  -14.124 22.066  1    57.12  ? 33  LYS A CG  1 
ATOM   278  C  CD  . LYS A 1 37  ? -7.038  -14.476 20.598  1    64.05  ? 33  LYS A CD  1 
ATOM   279  C  CE  . LYS A 1 37  ? -7.286  -15.919 20.241  1    70.6   ? 33  LYS A CE  1 
ATOM   280  N  NZ  . LYS A 1 37  ? -7.031  -16.158 18.816  1    61.39  ? 33  LYS A NZ  1 
ATOM   281  N  N   . LYS A 1 38  ? -6.412  -11.958 25.18   1    60.6   ? 34  LYS A N   1 
ATOM   282  C  CA  . LYS A 1 38  ? -6.169  -10.511 25.364  1    64.3   ? 34  LYS A CA  1 
ATOM   283  C  C   . LYS A 1 38  ? -5.439  -9.947  24.147  1    71.28  ? 34  LYS A C   1 
ATOM   284  O  O   . LYS A 1 38  ? -4.395  -10.507 23.781  1    76.93  ? 34  LYS A O   1 
ATOM   285  C  CB  . LYS A 1 38  ? -5.28   -10.223 26.573  1    65.8   ? 34  LYS A CB  1 
ATOM   286  C  CG  . LYS A 1 38  ? -4.966  -8.747  26.773  1    77.07  ? 34  LYS A CG  1 
ATOM   287  C  CD  . LYS A 1 38  ? -4.227  -8.443  28.068  1    84.26  ? 34  LYS A CD  1 
ATOM   288  C  CE  . LYS A 1 38  ? -2.748  -8.582  27.921  1    95.24  ? 34  LYS A CE  1 
ATOM   289  N  NZ  . LYS A 1 38  ? -2.035  -8.007  29.063  1    105.01 ? 34  LYS A NZ  1 
ATOM   290  N  N   . ILE A 1 39  ? -5.99   -8.899  23.536  1    75.78  ? 35  ILE A N   1 
ATOM   291  C  CA  . ILE A 1 39  ? -5.298  -8.208  22.412  1    75.21  ? 35  ILE A CA  1 
ATOM   292  C  C   . ILE A 1 39  ? -4.915  -6.822  22.944  1    81.56  ? 35  ILE A C   1 
ATOM   293  O  O   . ILE A 1 39  ? -5.827  -6.016  23.183  1    80.71  ? 35  ILE A O   1 
ATOM   294  C  CB  . ILE A 1 39  ? -6.206  -8.12   21.175  1    71.8   ? 35  ILE A CB  1 
ATOM   295  C  CG1 . ILE A 1 39  ? -6.98   -9.419  20.947  1    74.68  ? 35  ILE A CG1 1 
ATOM   296  C  CG2 . ILE A 1 39  ? -5.415  -7.706  19.936  1    65.48  ? 35  ILE A CG2 1 
ATOM   297  C  CD1 . ILE A 1 39  ? -6.157  -10.533 20.328  1    75.1   ? 35  ILE A CD1 1 
ATOM   298  N  N   . ARG A 1 40  ? -3.624  -6.57   23.151  1    93.37  ? 36  ARG A N   1 
ATOM   299  C  CA  . ARG A 1 40  ? -3.202  -5.278  23.753  1    111.11 ? 36  ARG A CA  1 
ATOM   300  C  C   . ARG A 1 40  ? -3.262  -4.169  22.7    1    118.08 ? 36  ARG A C   1 
ATOM   301  O  O   . ARG A 1 40  ? -2.271  -3.979  21.974  1    115.58 ? 36  ARG A O   1 
ATOM   302  C  CB  . ARG A 1 40  ? -1.805  -5.343  24.374  1    112.78 ? 36  ARG A CB  1 
ATOM   303  C  CG  . ARG A 1 40  ? -1.873  -5.309  25.893  1    112.77 ? 36  ARG A CG  1 
ATOM   304  C  CD  . ARG A 1 40  ? -0.517  -5.544  26.529  1    108.33 ? 36  ARG A CD  1 
ATOM   305  N  NE  . ARG A 1 40  ? -0.52   -5.174  27.948  1    118.7  ? 36  ARG A NE  1 
ATOM   306  C  CZ  . ARG A 1 40  ? -0.29   -3.951  28.403  1    119.19 ? 36  ARG A CZ  1 
ATOM   307  N  NH1 . ARG A 1 40  ? -0.537  -3.658  29.666  1    127.62 ? 36  ARG A NH1 1 
ATOM   308  N  NH2 . ARG A 1 40  ? 0.19    -3.025  27.596  1    114.79 ? 36  ARG A NH2 1 
ATOM   309  N  N   . LEU A 1 41  ? -4.409  -3.498  22.602  1    119.62 ? 37  LEU A N   1 
ATOM   310  C  CA  . LEU A 1 41  ? -4.514  -2.348  21.678  1    116.33 ? 37  LEU A CA  1 
ATOM   311  C  C   . LEU A 1 41  ? -3.578  -1.281  22.241  1    147.07 ? 37  LEU A C   1 
ATOM   312  O  O   . LEU A 1 41  ? -3.227  -0.361  21.509  1    169.04 ? 37  LEU A O   1 
ATOM   313  C  CB  . LEU A 1 41  ? -5.949  -1.844  21.58   1    95.64  ? 37  LEU A CB  1 
ATOM   314  C  CG  . LEU A 1 41  ? -7.029  -2.92   21.461  1    88.58  ? 37  LEU A CG  1 
ATOM   315  C  CD1 . LEU A 1 41  ? -8.4    -2.294  21.634  1    87.64  ? 37  LEU A CD1 1 
ATOM   316  C  CD2 . LEU A 1 41  ? -6.907  -3.581  20.105  1    88.44  ? 37  LEU A CD2 1 
ATOM   317  N  N   . ASP A 1 42  ? -3.185  -1.421  23.507  1    173.15 ? 38  ASP A N   1 
ATOM   318  C  CA  . ASP A 1 42  ? -2.211  -0.472  24.111  1    166.94 ? 38  ASP A CA  1 
ATOM   319  C  C   . ASP A 1 42  ? -1.204  -0.076  23.03   1    160.6  ? 38  ASP A C   1 
ATOM   320  O  O   . ASP A 1 42  ? -1      1.135   22.828  1    142.84 ? 38  ASP A O   1 
ATOM   321  C  CB  . ASP A 1 42  ? -1.572  -1.09   25.343  1    170.08 ? 38  ASP A CB  1 
ATOM   322  C  CG  . ASP A 1 42  ? -2.443  -1.094  26.589  1    172.9  ? 38  ASP A CG  1 
ATOM   323  O  OD1 . ASP A 1 42  ? -2.8    0.006   27.055  1    174.3  ? 38  ASP A OD1 1 
ATOM   324  O  OD2 . ASP A 1 42  ? -2.756  -2.197  27.079  1    166.18 ? 38  ASP A OD2 1 
ATOM   325  N  N   . THR A 1 43  ? -0.591  -1.067  22.38   1    166.12 ? 39  THR A N   1 
ATOM   326  C  CA  . THR A 1 43  ? 0.323   -0.793  21.255  1    153.28 ? 39  THR A CA  1 
ATOM   327  C  C   . THR A 1 43  ? -0.539  -0.64   20.021  1    156.4  ? 39  THR A C   1 
ATOM   328  O  O   . THR A 1 43  ? -0.819  -1.663  19.365  1    135.17 ? 39  THR A O   1 
ATOM   329  C  CB  . THR A 1 43  ? 1.313   -1.947  21.156  1    129.93 ? 39  THR A CB  1 
ATOM   330  O  OG1 . THR A 1 43  ? 0.509   -3.109  20.989  1    115.34 ? 39  THR A OG1 1 
ATOM   331  C  CG2 . THR A 1 43  ? 2.144   -2.1    22.414  1    119.02 ? 39  THR A CG2 1 
ATOM   332  N  N   . GLU A 1 44  ? -0.98   0.583   19.722  1    163.08 ? 40  GLU A N   1 
ATOM   333  C  CA  . GLU A 1 44  ? -1.933  0.784   18.606  1    146.81 ? 40  GLU A CA  1 
ATOM   334  C  C   . GLU A 1 44  ? -1.372  1.732   17.543  1    149.16 ? 40  GLU A C   1 
ATOM   335  O  O   . GLU A 1 44  ? -2.176  2.479   16.961  1    174.3  ? 40  GLU A O   1 
ATOM   336  C  CB  . GLU A 1 44  ? -3.191  1.471   19.128  1    138.35 ? 40  GLU A CB  1 
ATOM   337  C  CG  . GLU A 1 44  ? -2.924  2.868   19.685  1    124.53 ? 40  GLU A CG  1 
ATOM   338  C  CD  . GLU A 1 44  ? -4.099  3.576   20.332  1    117.86 ? 40  GLU A CD  1 
ATOM   339  O  OE1 . GLU A 1 44  ? -5.244  3.156   20.076  1    107.36 ? 40  GLU A OE1 1 
ATOM   340  O  OE2 . GLU A 1 44  ? -3.872  4.54    21.093  1    120.91 ? 40  GLU A OE2 1 
ATOM   341  N  N   . THR A 1 45  ? -0.067  1.72    17.294  1    130.54 ? 41  THR A N   1 
ATOM   342  C  CA  . THR A 1 45  ? 0.424   2.584   16.206  1    120.97 ? 41  THR A CA  1 
ATOM   343  C  C   . THR A 1 45  ? -0.527  2.443   15.036  1    105.35 ? 41  THR A C   1 
ATOM   344  O  O   . THR A 1 45  ? -0.689  3.409   14.282  1    106.46 ? 41  THR A O   1 
ATOM   345  C  CB  . THR A 1 45  ? 1.86    2.203   15.852  1    126.96 ? 41  THR A CB  1 
ATOM   346  O  OG1 . THR A 1 45  ? 2.598   2.441   17.046  1    134.03 ? 41  THR A OG1 1 
ATOM   347  C  CG2 . THR A 1 45  ? 2.434   3.025   14.713  1    121.06 ? 41  THR A CG2 1 
ATOM   348  N  N   . GLU A 1 46  ? -1.159  1.282   14.88   1    82.72  ? 42  GLU A N   1 
ATOM   349  C  CA  . GLU A 1 46  ? -2.016  1.1     13.69   1    76.97  ? 42  GLU A CA  1 
ATOM   350  C  C   . GLU A 1 46  ? -3.449  0.816   14.138  1    70.42  ? 42  GLU A C   1 
ATOM   351  O  O   . GLU A 1 46  ? -4.226  0.316   13.326  1    70.15  ? 42  GLU A O   1 
ATOM   352  C  CB  . GLU A 1 46  ? -1.421  -0.009  12.832  1    79.1   ? 42  GLU A CB  1 
ATOM   353  C  CG  . GLU A 1 46  ? -0.171  0.435   12.079  1    86.23  ? 42  GLU A CG  1 
ATOM   354  C  CD  . GLU A 1 46  ? -0.401  1.634   11.179  1    86.28  ? 42  GLU A CD  1 
ATOM   355  O  OE1 . GLU A 1 46  ? -1.194  1.509   10.227  1    84.86  ? 42  GLU A OE1 1 
ATOM   356  O  OE2 . GLU A 1 46  ? 0.211   2.689   11.43   1    80.83  ? 42  GLU A OE2 1 
ATOM   357  N  N   . GLY A 1 47  ? -3.776  1.145   15.381  1    66.54  ? 43  GLY A N   1 
ATOM   358  C  CA  . GLY A 1 47  ? -5.136  0.952   15.874  1    61.31  ? 43  GLY A CA  1 
ATOM   359  C  C   . GLY A 1 47  ? -5.441  -0.523  16.096  1    57.2   ? 43  GLY A C   1 
ATOM   360  O  O   . GLY A 1 47  ? -4.548  -1.3    16.4    1    61.56  ? 43  GLY A O   1 
ATOM   361  N  N   . VAL A 1 48  ? -6.695  -0.932  15.906  1    52.13  ? 44  VAL A N   1 
ATOM   362  C  CA  . VAL A 1 48  ? -7.034  -2.319  16.14   1    47.13  ? 44  VAL A CA  1 
ATOM   363  C  C   . VAL A 1 48  ? -6.442  -3.18   15.023  1    48.71  ? 44  VAL A C   1 
ATOM   364  O  O   . VAL A 1 48  ? -6.642  -2.911  13.839  1    48.98  ? 44  VAL A O   1 
ATOM   365  C  CB  . VAL A 1 48  ? -8.551  -2.525  16.29   1    44.66  ? 44  VAL A CB  1 
ATOM   366  C  CG1 . VAL A 1 48  ? -8.898  -3.988  16.517  1    41.58  ? 44  VAL A CG1 1 
ATOM   367  C  CG2 . VAL A 1 48  ? -9.131  -1.665  17.397  1    45.97  ? 44  VAL A CG2 1 
ATOM   368  N  N   . PRO A 1 49  ? -5.723  -4.275  15.353  1    49.19  ? 45  PRO A N   1 
ATOM   369  C  CA  . PRO A 1 49  ? -5.116  -5.127  14.336  1    49.83  ? 45  PRO A CA  1 
ATOM   370  C  C   . PRO A 1 49  ? -6.15   -5.711  13.378  1    51.12  ? 45  PRO A C   1 
ATOM   371  O  O   . PRO A 1 49  ? -7.244  -6.075  13.783  1    51.58  ? 45  PRO A O   1 
ATOM   372  C  CB  . PRO A 1 49  ? -4.422  -6.248  15.153  1    46.97  ? 45  PRO A CB  1 
ATOM   373  C  CG  . PRO A 1 49  ? -4.326  -5.71   16.52   1    47.93  ? 45  PRO A CG  1 
ATOM   374  C  CD  . PRO A 1 49  ? -5.485  -4.76   16.715  1    49.25  ? 45  PRO A CD  1 
ATOM   375  N  N   . SER A 1 50  ? -5.761  -5.863  12.112  1    53     ? 46  SER A N   1 
ATOM   376  C  CA  . SER A 1 50  ? -6.612  -6.48   11.104  1    49.59  ? 46  SER A CA  1 
ATOM   377  C  C   . SER A 1 50  ? -6.925  -7.934  11.438  1    47.99  ? 46  SER A C   1 
ATOM   378  O  O   . SER A 1 50  ? -8.014  -8.426  11.122  1    53.02  ? 46  SER A O   1 
ATOM   379  C  CB  . SER A 1 50  ? -6.016  -6.347  9.739   1    51.08  ? 46  SER A CB  1 
ATOM   380  O  OG  . SER A 1 50  ? -4.739  -6.971  9.665   1    60.47  ? 46  SER A OG  1 
ATOM   381  N  N   . THR A 1 51  ? -5.988  -8.637  12.081  1    50.23  ? 47  THR A N   1 
ATOM   382  C  CA  . THR A 1 51  ? -6.238  -10.035 12.427  1    48.9   ? 47  THR A CA  1 
ATOM   383  C  C   . THR A 1 51  ? -7.43   -10.106 13.364  1    41.05  ? 47  THR A C   1 
ATOM   384  O  O   . THR A 1 51  ? -8.268  -10.976 13.175  1    39.8   ? 47  THR A O   1 
ATOM   385  C  CB  . THR A 1 51  ? -5.037  -10.809 12.979  1    51.68  ? 47  THR A CB  1 
ATOM   386  O  OG1 . THR A 1 51  ? -4.517  -10.025 14.046  1    63.73  ? 47  THR A OG1 1 
ATOM   387  C  CG2 . THR A 1 51  ? -3.949  -11.013 11.945  1    51.75  ? 47  THR A CG2 1 
ATOM   388  N  N   . ALA A 1 52  ? -7.515  -9.168  14.311  1    41.2   ? 48  ALA A N   1 
ATOM   389  C  CA  . ALA A 1 52  ? -8.549  -9.181  15.35   1    43.32  ? 48  ALA A CA  1 
ATOM   390  C  C   . ALA A 1 52  ? -9.906  -8.768  14.764  1    43.53  ? 48  ALA A C   1 
ATOM   391  O  O   . ALA A 1 52  ? -10.933 -9.314  15.138  1    46.72  ? 48  ALA A O   1 
ATOM   392  C  CB  . ALA A 1 52  ? -8.156  -8.314  16.556  1    38.94  ? 48  ALA A CB  1 
ATOM   393  N  N   . ILE A 1 53  ? -9.895  -7.79   13.855  1    41.08  ? 49  ILE A N   1 
ATOM   394  C  CA  . ILE A 1 53  ? -11.081 -7.315  13.17   1    40.2   ? 49  ILE A CA  1 
ATOM   395  C  C   . ILE A 1 53  ? -11.72  -8.445  12.358  1    39.94  ? 49  ILE A C   1 
ATOM   396  O  O   . ILE A 1 53  ? -12.929 -8.651  12.417  1    38.71  ? 49  ILE A O   1 
ATOM   397  C  CB  . ILE A 1 53  ? -10.674 -6.12   12.301  1    39.84  ? 49  ILE A CB  1 
ATOM   398  C  CG1 . ILE A 1 53  ? -10.609 -4.863  13.198  1    39.2   ? 49  ILE A CG1 1 
ATOM   399  C  CG2 . ILE A 1 53  ? -11.637 -5.99   11.122  1    39.95  ? 49  ILE A CG2 1 
ATOM   400  C  CD1 . ILE A 1 53  ? -10.065 -3.623  12.534  1    39.96  ? 49  ILE A CD1 1 
ATOM   401  N  N   . ARG A 1 54  ? -10.895 -9.173  11.611  1    38.93  ? 50  ARG A N   1 
ATOM   402  C  CA  . ARG A 1 54  ? -11.346 -10.366 10.917  1    40.11  ? 50  ARG A CA  1 
ATOM   403  C  C   . ARG A 1 54  ? -11.816 -11.441 11.902  1    40.76  ? 50  ARG A C   1 
ATOM   404  O  O   . ARG A 1 54  ? -12.893 -11.99  11.723  1    39.95  ? 50  ARG A O   1 
ATOM   405  C  CB  . ARG A 1 54  ? -10.243 -10.931 10.018  1    37.7   ? 50  ARG A CB  1 
ATOM   406  C  CG  . ARG A 1 54  ? -10.01  -10.035 8.807   1    40.08  ? 50  ARG A CG  1 
ATOM   407  C  CD  . ARG A 1 54  ? -8.997  -10.631 7.849   1    37.53  ? 50  ARG A CD  1 
ATOM   408  N  NE  . ARG A 1 54  ? -8.811  -9.781  6.682   1    37.85  ? 50  ARG A NE  1 
ATOM   409  C  CZ  . ARG A 1 54  ? -7.84   -9.981  5.795   1    37.51  ? 50  ARG A CZ  1 
ATOM   410  N  NH1 . ARG A 1 54  ? -6.971  -10.97  5.959   1    33.99  ? 50  ARG A NH1 1 
ATOM   411  N  NH2 . ARG A 1 54  ? -7.728  -9.157  4.776   1    35.31  ? 50  ARG A NH2 1 
ATOM   412  N  N   . GLU A 1 55  ? -11.018 -11.765 12.929  1    44.06  ? 51  GLU A N   1 
ATOM   413  C  CA  . GLU A 1 55  ? -11.381 -12.861 13.822  1    42.58  ? 51  GLU A CA  1 
ATOM   414  C  C   . GLU A 1 55  ? -12.766 -12.597 14.409  1    39.44  ? 51  GLU A C   1 
ATOM   415  O  O   . GLU A 1 55  ? -13.624 -13.472 14.356  1    34.89  ? 51  GLU A O   1 
ATOM   416  C  CB  . GLU A 1 55  ? -10.32  -13.148 14.886  1    43.89  ? 51  GLU A CB  1 
ATOM   417  C  CG  . GLU A 1 55  ? -10.692 -14.332 15.771  1    48.83  ? 51  GLU A CG  1 
ATOM   418  C  CD  . GLU A 1 55  ? -9.593  -14.921 16.653  1    54.63  ? 51  GLU A CD  1 
ATOM   419  O  OE1 . GLU A 1 55  ? -8.632  -14.177 16.961  1    45.68  ? 51  GLU A OE1 1 
ATOM   420  O  OE2 . GLU A 1 55  ? -9.694  -16.169 16.973  1    64.2   ? 51  GLU A OE2 1 
ATOM   421  N  N   . ILE A 1 56  ? -12.968 -11.373 14.924  1    37.68  ? 52  ILE A N   1 
ATOM   422  C  CA  . ILE A 1 56  ? -14.163 -11.054 15.673  1    40.66  ? 52  ILE A CA  1 
ATOM   423  C  C   . ILE A 1 56  ? -15.337 -11.016 14.707  1    43.2   ? 52  ILE A C   1 
ATOM   424  O  O   . ILE A 1 56  ? -16.356 -11.656 14.976  1    47.37  ? 52  ILE A O   1 
ATOM   425  C  CB  . ILE A 1 56  ? -14.068 -9.732  16.469  1    42.73  ? 52  ILE A CB  1 
ATOM   426  C  CG1 . ILE A 1 56  ? -12.901 -9.728  17.462  1    42.81  ? 52  ILE A CG1 1 
ATOM   427  C  CG2 . ILE A 1 56  ? -15.391 -9.457  17.18   1    39.17  ? 52  ILE A CG2 1 
ATOM   428  C  CD1 . ILE A 1 56  ? -12.518 -8.349  17.948  1    42.65  ? 52  ILE A CD1 1 
ATOM   429  N  N   . SER A 1 57  ? -15.209 -10.25  13.617  1    42.11  ? 53  SER A N   1 
ATOM   430  C  CA  . SER A 1 57  ? -16.333 -10.099 12.688  1    45.12  ? 53  SER A CA  1 
ATOM   431  C  C   . SER A 1 57  ? -16.771 -11.459 12.122  1    43.86  ? 53  SER A C   1 
ATOM   432  O  O   . SER A 1 57  ? -17.967 -11.732 11.967  1    49.4   ? 53  SER A O   1 
ATOM   433  C  CB  . SER A 1 57  ? -16.061 -9.104  11.583  1    43.08  ? 53  SER A CB  1 
ATOM   434  O  OG  . SER A 1 57  ? -14.949 -9.573  10.822  1    45.98  ? 53  SER A OG  1 
ATOM   435  N  N   . LEU A 1 58  ? -15.802 -12.31  11.814  1    37.29  ? 54  LEU A N   1 
ATOM   436  C  CA  . LEU A 1 58  ? -16.13  -13.579 11.201  1    38.97  ? 54  LEU A CA  1 
ATOM   437  C  C   . LEU A 1 58  ? -16.694 -14.559 12.226  1    44.28  ? 54  LEU A C   1 
ATOM   438  O  O   . LEU A 1 58  ? -17.639 -15.282 11.902  1    48.84  ? 54  LEU A O   1 
ATOM   439  C  CB  . LEU A 1 58  ? -14.952 -14.153 10.446  1    33.77  ? 54  LEU A CB  1 
ATOM   440  C  CG  . LEU A 1 58  ? -14.405 -13.226 9.35    1    35.42  ? 54  LEU A CG  1 
ATOM   441  C  CD1 . LEU A 1 58  ? -13.155 -13.821 8.667   1    33.4   ? 54  LEU A CD1 1 
ATOM   442  C  CD2 . LEU A 1 58  ? -15.504 -12.92  8.368   1    31.57  ? 54  LEU A CD2 1 
ATOM   443  N  N   . LEU A 1 59  ? -16.162 -14.568 13.458  1    46.72  ? 55  LEU A N   1 
ATOM   444  C  CA  . LEU A 1 59  ? -16.623 -15.54  14.441  1    47.27  ? 55  LEU A CA  1 
ATOM   445  C  C   . LEU A 1 59  ? -18.03  -15.21  14.935  1    55.1   ? 55  LEU A C   1 
ATOM   446  O  O   . LEU A 1 59  ? -18.748 -16.104 15.381  1    53.49  ? 55  LEU A O   1 
ATOM   447  C  CB  . LEU A 1 59  ? -15.669 -15.659 15.613  1    41.46  ? 55  LEU A CB  1 
ATOM   448  C  CG  . LEU A 1 59  ? -14.549 -16.67  15.419  1    42.65  ? 55  LEU A CG  1 
ATOM   449  C  CD1 . LEU A 1 59  ? -13.7   -16.697 16.677  1    43.05  ? 55  LEU A CD1 1 
ATOM   450  C  CD2 . LEU A 1 59  ? -15.079 -18.037 15.066  1    41.99  ? 55  LEU A CD2 1 
ATOM   451  N  N   . LYS A 1 60  ? -18.397 -13.923 14.875  1    61.35  ? 56  LYS A N   1 
ATOM   452  C  CA  . LYS A 1 60  ? -19.694 -13.463 15.331  1    60.7   ? 56  LYS A CA  1 
ATOM   453  C  C   . LYS A 1 60  ? -20.797 -14.296 14.684  1    65.4   ? 56  LYS A C   1 
ATOM   454  O  O   . LYS A 1 60  ? -21.714 -14.76  15.364  1    71.11  ? 56  LYS A O   1 
ATOM   455  C  CB  . LYS A 1 60  ? -19.867 -11.968 15.04   1    61.49  ? 56  LYS A CB  1 
ATOM   456  C  CG  . LYS A 1 60  ? -19.517 -11.093 16.249  1    61.26  ? 56  LYS A CG  1 
ATOM   457  C  CD  . LYS A 1 60  ? -20.394 -9.842  16.201  1    69     ? 56  LYS A CD  1 
ATOM   458  C  CE  . LYS A 1 60  ? -20.491 -9.113  17.5    1    77.37  ? 56  LYS A CE  1 
ATOM   459  N  NZ  . LYS A 1 60  ? -21.734 -8.323  17.517  1    78.82  ? 56  LYS A NZ  1 
ATOM   460  N  N   . GLU A 1 61  ? -20.662 -14.523 13.372  1    68.67  ? 57  GLU A N   1 
ATOM   461  C  CA  . GLU A 1 61  ? -21.721 -15.113 12.568  1    76.8   ? 57  GLU A CA  1 
ATOM   462  C  C   . GLU A 1 61  ? -21.59  -16.635 12.412  1    61.68  ? 57  GLU A C   1 
ATOM   463  O  O   . GLU A 1 61  ? -22.498 -17.277 11.889  1    66.73  ? 57  GLU A O   1 
ATOM   464  C  CB  . GLU A 1 61  ? -21.781 -14.313 11.266  1    85.55  ? 57  GLU A CB  1 
ATOM   465  C  CG  . GLU A 1 61  ? -22.792 -13.163 11.317  1    96.68  ? 57  GLU A CG  1 
ATOM   466  C  CD  . GLU A 1 61  ? -24.251 -13.445 11.706  1    89.03  ? 57  GLU A CD  1 
ATOM   467  O  OE1 . GLU A 1 61  ? -24.821 -14.501 11.28   1    69.62  ? 57  GLU A OE1 1 
ATOM   468  O  OE2 . GLU A 1 61  ? -24.813 -12.572 12.436  1    83.7   ? 57  GLU A OE2 1 
ATOM   469  N  N   . LEU A 1 62  ? -20.486 -17.212 12.869  1    45.5   ? 58  LEU A N   1 
ATOM   470  C  CA  . LEU A 1 62  ? -20.268 -18.64  12.741  1    47.85  ? 58  LEU A CA  1 
ATOM   471  C  C   . LEU A 1 62  ? -20.69  -19.345 14.024  1    46.37  ? 58  LEU A C   1 
ATOM   472  O  O   . LEU A 1 62  ? -19.832 -19.66  14.828  1    50.89  ? 58  LEU A O   1 
ATOM   473  C  CB  . LEU A 1 62  ? -18.791 -18.922 12.439  1    39.85  ? 58  LEU A CB  1 
ATOM   474  C  CG  . LEU A 1 62  ? -18.298 -18.378 11.102  1    40.28  ? 58  LEU A CG  1 
ATOM   475  C  CD1 . LEU A 1 62  ? -16.821 -18.518 10.991  1    45.61  ? 58  LEU A CD1 1 
ATOM   476  C  CD2 . LEU A 1 62  ? -18.969 -18.989 9.878   1    41.9   ? 58  LEU A CD2 1 
ATOM   477  N  N   . ASN A 1 63  ? -21.98  -19.629 14.192  1    47.47  ? 59  ASN A N   1 
ATOM   478  C  CA  . ASN A 1 63  ? -22.421 -20.452 15.312  1    50.67  ? 59  ASN A CA  1 
ATOM   479  C  C   . ASN A 1 63  ? -22.565 -21.882 14.816  1    41.94  ? 59  ASN A C   1 
ATOM   480  O  O   . ASN A 1 63  ? -23.415 -22.175 13.989  1    45.38  ? 59  ASN A O   1 
ATOM   481  C  CB  . ASN A 1 63  ? -23.673 -19.896 15.992  1    57.59  ? 59  ASN A CB  1 
ATOM   482  C  CG  . ASN A 1 63  ? -23.392 -18.519 16.536  1    80.38  ? 59  ASN A CG  1 
ATOM   483  O  OD1 . ASN A 1 63  ? -23.868 -17.503 16.009  1    97.74  ? 59  ASN A OD1 1 
ATOM   484  N  ND2 . ASN A 1 63  ? -22.538 -18.459 17.545  1    89.72  ? 59  ASN A ND2 1 
ATOM   485  N  N   . HIS A 1 64  ? -21.702 -22.758 15.303  1    36.97  ? 60  HIS A N   1 
ATOM   486  C  CA  . HIS A 1 64  ? -21.744 -24.15  14.898  1    38.86  ? 60  HIS A CA  1 
ATOM   487  C  C   . HIS A 1 64  ? -21.047 -24.983 15.977  1    38.89  ? 60  HIS A C   1 
ATOM   488  O  O   . HIS A 1 64  ? -20.023 -24.559 16.516  1    37.29  ? 60  HIS A O   1 
ATOM   489  C  CB  . HIS A 1 64  ? -21.089 -24.297 13.514  1    36.58  ? 60  HIS A CB  1 
ATOM   490  C  CG  . HIS A 1 64  ? -21.214 -25.673 12.993  1    39.41  ? 60  HIS A CG  1 
ATOM   491  N  ND1 . HIS A 1 64  ? -20.315 -26.668 13.341  1    41.45  ? 60  HIS A ND1 1 
ATOM   492  C  CD2 . HIS A 1 64  ? -22.101 -26.232 12.155  1    38.3   ? 60  HIS A CD2 1 
ATOM   493  C  CE1 . HIS A 1 64  ? -20.654 -27.8   12.726  1    41.88  ? 60  HIS A CE1 1 
ATOM   494  N  NE2 . HIS A 1 64  ? -21.73  -27.547 11.995  1    40.34  ? 60  HIS A NE2 1 
ATOM   495  N  N   . PRO A 1 65  ? -21.544 -26.205 16.297  1    41.64  ? 61  PRO A N   1 
ATOM   496  C  CA  . PRO A 1 65  ? -20.92  -27.031 17.337  1    40     ? 61  PRO A CA  1 
ATOM   497  C  C   . PRO A 1 65  ? -19.428 -27.306 17.129  1    40.39  ? 61  PRO A C   1 
ATOM   498  O  O   . PRO A 1 65  ? -18.72  -27.547 18.105  1    44.42  ? 61  PRO A O   1 
ATOM   499  C  CB  . PRO A 1 65  ? -21.744 -28.329 17.355  1    40     ? 61  PRO A CB  1 
ATOM   500  C  CG  . PRO A 1 65  ? -23.01  -27.963 16.667  1    40.2   ? 61  PRO A CG  1 
ATOM   501  C  CD  . PRO A 1 65  ? -22.702 -26.86  15.672  1    36.59  ? 61  PRO A CD  1 
ATOM   502  N  N   . ASN A 1 66  ? -18.941 -27.285 15.88   1    34.42  ? 62  ASN A N   1 
ATOM   503  C  CA  . ASN A 1 66  ? -17.561 -27.671 15.609  1    33.53  ? 62  ASN A CA  1 
ATOM   504  C  C   . ASN A 1 66  ? -16.723 -26.443 15.246  1    34.34  ? 62  ASN A C   1 
ATOM   505  O  O   . ASN A 1 66  ? -15.702 -26.545 14.566  1    35.45  ? 62  ASN A O   1 
ATOM   506  C  CB  . ASN A 1 66  ? -17.538 -28.769 14.551  1    32.26  ? 62  ASN A CB  1 
ATOM   507  C  CG  . ASN A 1 66  ? -18.286 -29.975 15.062  1    37.41  ? 62  ASN A CG  1 
ATOM   508  O  OD1 . ASN A 1 66  ? -19.405 -30.248 14.626  1    42.73  ? 62  ASN A OD1 1 
ATOM   509  N  ND2 . ASN A 1 66  ? -17.773 -30.642 16.084  1    37.14  ? 62  ASN A ND2 1 
ATOM   510  N  N   . ILE A 1 67  ? -17.194 -25.262 15.652  1    34.15  ? 63  ILE A N   1 
ATOM   511  C  CA  . ILE A 1 67  ? -16.405 -24.045 15.575  1    34.16  ? 63  ILE A CA  1 
ATOM   512  C  C   . ILE A 1 67  ? -16.486 -23.45  16.975  1    36.52  ? 63  ILE A C   1 
ATOM   513  O  O   . ILE A 1 67  ? -17.578 -23.356 17.519  1    44.15  ? 63  ILE A O   1 
ATOM   514  C  CB  . ILE A 1 67  ? -16.949 -23.073 14.508  1    32.36  ? 63  ILE A CB  1 
ATOM   515  C  CG1 . ILE A 1 67  ? -17.011 -23.741 13.128  1    31.29  ? 63  ILE A CG1 1 
ATOM   516  C  CG2 . ILE A 1 67  ? -16.141 -21.768 14.484  1    28.92  ? 63  ILE A CG2 1 
ATOM   517  C  CD1 . ILE A 1 67  ? -17.816 -22.952 12.105  1    32.67  ? 63  ILE A CD1 1 
ATOM   518  N  N   . VAL A 1 68  ? -15.331 -23.101 17.552  1    41.57  ? 64  VAL A N   1 
ATOM   519  C  CA  . VAL A 1 68  ? -15.217 -22.513 18.884  1    43.2   ? 64  VAL A CA  1 
ATOM   520  C  C   . VAL A 1 68  ? -16.06  -21.239 18.93   1    40.8   ? 64  VAL A C   1 
ATOM   521  O  O   . VAL A 1 68  ? -16.007 -20.4   18.012  1    39.8   ? 64  VAL A O   1 
ATOM   522  C  CB  . VAL A 1 68  ? -13.735 -22.197 19.222  1    45.7   ? 64  VAL A CB  1 
ATOM   523  C  CG1 . VAL A 1 68  ? -13.145 -21.151 18.232  1    45.29  ? 64  VAL A CG1 1 
ATOM   524  C  CG2 . VAL A 1 68  ? -13.564 -21.777 20.683  1    40.49  ? 64  VAL A CG2 1 
ATOM   525  N  N   . LYS A 1 69  ? -16.792 -21.077 20.038  1    40.64  ? 65  LYS A N   1 
ATOM   526  C  CA  . LYS A 1 69  ? -17.717 -19.969 20.152  1    43.79  ? 65  LYS A CA  1 
ATOM   527  C  C   . LYS A 1 69  ? -17.055 -18.757 20.801  1    45.72  ? 65  LYS A C   1 
ATOM   528  O  O   . LYS A 1 69  ? -16.493 -18.875 21.905  1    50.65  ? 65  LYS A O   1 
ATOM   529  C  CB  . LYS A 1 69  ? -18.947 -20.425 20.944  1    49.88  ? 65  LYS A CB  1 
ATOM   530  C  CG  . LYS A 1 69  ? -20.141 -19.487 20.833  1    55.43  ? 65  LYS A CG  1 
ATOM   531  C  CD  . LYS A 1 69  ? -21.431 -20.29  20.914  1    66.44  ? 65  LYS A CD  1 
ATOM   532  C  CE  . LYS A 1 69  ? -22.537 -19.396 21.418  1    69.77  ? 65  LYS A CE  1 
ATOM   533  N  NZ  . LYS A 1 69  ? -22.939 -18.431 20.396  1    74.18  ? 65  LYS A NZ  1 
ATOM   534  N  N   . LEU A 1 70  ? -17.167 -17.597 20.118  1    43.55  ? 66  LEU A N   1 
ATOM   535  C  CA  . LEU A 1 70  ? -16.897 -16.298 20.723  1    41.11  ? 66  LEU A CA  1 
ATOM   536  C  C   . LEU A 1 70  ? -18.125 -15.916 21.534  1    41.4   ? 66  LEU A C   1 
ATOM   537  O  O   . LEU A 1 70  ? -19.195 -15.749 20.953  1    42.6   ? 66  LEU A O   1 
ATOM   538  C  CB  . LEU A 1 70  ? -16.633 -15.263 19.628  1    41.44  ? 66  LEU A CB  1 
ATOM   539  C  CG  . LEU A 1 70  ? -16.065 -13.918 20.095  1    41.4   ? 66  LEU A CG  1 
ATOM   540  C  CD1 . LEU A 1 70  ? -14.729 -14.084 20.871  1    44.23  ? 66  LEU A CD1 1 
ATOM   541  C  CD2 . LEU A 1 70  ? -15.846 -13.04  18.883  1    40.32  ? 66  LEU A CD2 1 
ATOM   542  N  N   . LEU A 1 71  ? -17.97  -15.839 22.857  1    39.73  ? 67  LEU A N   1 
ATOM   543  C  CA  . LEU A 1 71  ? -19.079 -15.545 23.739  1    39.35  ? 67  LEU A CA  1 
ATOM   544  C  C   . LEU A 1 71  ? -19.244 -14.044 23.866  1    39.86  ? 67  LEU A C   1 
ATOM   545  O  O   . LEU A 1 71  ? -20.348 -13.57  24.103  1    41.17  ? 67  LEU A O   1 
ATOM   546  C  CB  . LEU A 1 71  ? -18.858 -16.183 25.112  1    42.1   ? 67  LEU A CB  1 
ATOM   547  C  CG  . LEU A 1 71  ? -18.447 -17.658 25.052  1    48.1   ? 67  LEU A CG  1 
ATOM   548  C  CD1 . LEU A 1 71  ? -18.004 -18.171 26.404  1    42.26  ? 67  LEU A CD1 1 
ATOM   549  C  CD2 . LEU A 1 71  ? -19.583 -18.514 24.461  1    48.4   ? 67  LEU A CD2 1 
ATOM   550  N  N   . ASP A 1 72  ? -18.134 -13.31  23.788  1    40.98  ? 68  ASP A N   1 
ATOM   551  C  CA  . ASP A 1 72  ? -18.191 -11.897 24.126  1    42.48  ? 68  ASP A CA  1 
ATOM   552  C  C   . ASP A 1 72  ? -16.906 -11.223 23.683  1    41.4   ? 68  ASP A C   1 
ATOM   553  O  O   . ASP A 1 72  ? -15.915 -11.911 23.447  1    42.25  ? 68  ASP A O   1 
ATOM   554  C  CB  . ASP A 1 72  ? -18.393 -11.683 25.619  1    43.17  ? 68  ASP A CB  1 
ATOM   555  C  CG  . ASP A 1 72  ? -19.175 -10.431 25.978  1    47.87  ? 68  ASP A CG  1 
ATOM   556  O  OD1 . ASP A 1 72  ? -19.439 -9.62   25.09   1    51     ? 68  ASP A OD1 1 
ATOM   557  O  OD2 . ASP A 1 72  ? -19.568 -10.321 27.139  1    55.39  ? 68  ASP A OD2 1 
ATOM   558  N  N   . VAL A 1 73  ? -16.964 -9.886  23.586  1    40.33  ? 69  VAL A N   1 
ATOM   559  C  CA  . VAL A 1 73  ? -15.838 -9.016  23.3    1    41.14  ? 69  VAL A CA  1 
ATOM   560  C  C   . VAL A 1 73  ? -15.914 -7.845  24.275  1    47.05  ? 69  VAL A C   1 
ATOM   561  O  O   . VAL A 1 73  ? -16.859 -7.059  24.216  1    51.07  ? 69  VAL A O   1 
ATOM   562  C  CB  . VAL A 1 73  ? -15.893 -8.506  21.851  1    39.38  ? 69  VAL A CB  1 
ATOM   563  C  CG1 . VAL A 1 73  ? -14.823 -7.443  21.563  1    38.77  ? 69  VAL A CG1 1 
ATOM   564  C  CG2 . VAL A 1 73  ? -15.855 -9.666  20.853  1    36.23  ? 69  VAL A CG2 1 
ATOM   565  N  N   . ILE A 1 74  ? -14.907 -7.736  25.143  1    48.95  ? 70  ILE A N   1 
ATOM   566  C  CA  . ILE A 1 74  ? -14.824 -6.579  26.08   1    54.32  ? 70  ILE A CA  1 
ATOM   567  C  C   . ILE A 1 74  ? -13.858 -5.572  25.447  1    60.59  ? 70  ILE A C   1 
ATOM   568  O  O   . ILE A 1 74  ? -12.671 -5.898  25.316  1    59.62  ? 70  ILE A O   1 
ATOM   569  C  CB  . ILE A 1 74  ? -14.439 -7.024  27.5    1    54.21  ? 70  ILE A CB  1 
ATOM   570  C  CG1 . ILE A 1 74  ? -15.592 -7.771  28.162  1    55.65  ? 70  ILE A CG1 1 
ATOM   571  C  CG2 . ILE A 1 74  ? -13.983 -5.838  28.347  1    52.86  ? 70  ILE A CG2 1 
ATOM   572  C  CD1 . ILE A 1 74  ? -15.219 -9.134  28.711  1    56.57  ? 70  ILE A CD1 1 
ATOM   573  N  N   . HIS A 1 75  ? -14.368 -4.405  25.062  1    72.08  ? 71  HIS A N   1 
ATOM   574  C  CA  . HIS A 1 75  ? -13.577 -3.411  24.296  1    83.5   ? 71  HIS A CA  1 
ATOM   575  C  C   . HIS A 1 75  ? -13.236 -2.215  25.172  1    84.84  ? 71  HIS A C   1 
ATOM   576  O  O   . HIS A 1 75  ? -13.957 -1.206  25.118  1    104.18 ? 71  HIS A O   1 
ATOM   577  C  CB  . HIS A 1 75  ? -14.437 -2.934  23.122  1    93.12  ? 71  HIS A CB  1 
ATOM   578  C  CG  . HIS A 1 75  ? -13.742 -2.333  21.951  1    107.43 ? 71  HIS A CG  1 
ATOM   579  N  ND1 . HIS A 1 75  ? -14.447 -1.587  21.032  1    120.04 ? 71  HIS A ND1 1 
ATOM   580  C  CD2 . HIS A 1 75  ? -12.479 -2.351  21.524  1    117.46 ? 71  HIS A CD2 1 
ATOM   581  C  CE1 . HIS A 1 75  ? -13.624 -1.169  20.086  1    124.13 ? 71  HIS A CE1 1 
ATOM   582  N  NE2 . HIS A 1 75  ? -12.426 -1.629  20.361  1    123.57 ? 71  HIS A NE2 1 
ATOM   583  N  N   . THR A 1 76  ? -12.159 -2.317  25.941  1    87.92  ? 72  THR A N   1 
ATOM   584  C  CA  . THR A 1 76  ? -11.72  -1.17   26.754  1    88.89  ? 72  THR A CA  1 
ATOM   585  C  C   . THR A 1 76  ? -10.934 -0.233  25.862  1    90.22  ? 72  THR A C   1 
ATOM   586  O  O   . THR A 1 76  ? -10.701 -0.576  24.688  1    74.96  ? 72  THR A O   1 
ATOM   587  C  CB  . THR A 1 76  ? -10.917 -1.675  27.952  1    82.91  ? 72  THR A CB  1 
ATOM   588  O  OG1 . THR A 1 76  ? -11.797 -2.502  28.704  1    85.37  ? 72  THR A OG1 1 
ATOM   589  C  CG2 . THR A 1 76  ? -10.413 -0.547  28.833  1    76.05  ? 72  THR A CG2 1 
ATOM   590  N  N   . GLU A 1 77  ? -10.529 0.915   26.397  1    97.04  ? 73  GLU A N   1 
ATOM   591  C  CA  . GLU A 1 77  ? -9.734  1.89    25.61   1    110.61 ? 73  GLU A CA  1 
ATOM   592  C  C   . GLU A 1 77  ? -8.291  1.409   25.532  1    105.29 ? 73  GLU A C   1 
ATOM   593  O  O   . GLU A 1 77  ? -7.57   1.824   24.606  1    99.8   ? 73  GLU A O   1 
ATOM   594  C  CB  . GLU A 1 77  ? -9.666  3.265   26.265  1    115.73 ? 73  GLU A CB  1 
ATOM   595  C  CG  . GLU A 1 77  ? -11.028 3.836   26.645  1    122.61 ? 73  GLU A CG  1 
ATOM   596  C  CD  . GLU A 1 77  ? -10.864 5.073   27.506  1    137.91 ? 73  GLU A CD  1 
ATOM   597  O  OE1 . GLU A 1 77  ? -10.035 5.934   27.142  1    132.17 ? 73  GLU A OE1 1 
ATOM   598  O  OE2 . GLU A 1 77  ? -11.549 5.17    28.543  1    151.52 ? 73  GLU A OE2 1 
ATOM   599  N  N   . ASN A 1 78  ? -7.9    0.562   26.474  1    97.5   ? 74  ASN A N   1 
ATOM   600  C  CA  . ASN A 1 78  ? -6.496  0.099   26.524  1    98.37  ? 74  ASN A CA  1 
ATOM   601  C  C   . ASN A 1 78  ? -6.389  -1.3    25.925  1    89.19  ? 74  ASN A C   1 
ATOM   602  O  O   . ASN A 1 78  ? -5.435  -1.548  25.17   1    93.54  ? 74  ASN A O   1 
ATOM   603  C  CB  . ASN A 1 78  ? -6.012  0.108   27.965  1    104.33 ? 74  ASN A CB  1 
ATOM   604  C  CG  . ASN A 1 78  ? -5.825  1.513   28.483  1    105.87 ? 74  ASN A CG  1 
ATOM   605  O  OD1 . ASN A 1 78  ? -5.641  2.447   27.695  1    119.5  ? 74  ASN A OD1 1 
ATOM   606  N  ND2 . ASN A 1 78  ? -5.859  1.681   29.796  1    100.05 ? 74  ASN A ND2 1 
ATOM   607  N  N   . LYS A 1 79  ? -7.34   -2.173  26.242  1    81.6   ? 75  LYS A N   1 
ATOM   608  C  CA  . LYS A 1 79  ? -7.2    -3.578  25.798  1    75.77  ? 75  LYS A CA  1 
ATOM   609  C  C   . LYS A 1 79  ? -8.468  -4.118  25.142  1    68.96  ? 75  LYS A C   1 
ATOM   610  O  O   . LYS A 1 79  ? -9.525  -3.474  25.233  1    68.76  ? 75  LYS A O   1 
ATOM   611  C  CB  . LYS A 1 79  ? -6.905  -4.46   27.01   1    79.88  ? 75  LYS A CB  1 
ATOM   612  C  CG  . LYS A 1 79  ? -5.438  -4.618  27.36   1    95.93  ? 75  LYS A CG  1 
ATOM   613  C  CD  . LYS A 1 79  ? -5.243  -4.869  28.849  1    105.31 ? 75  LYS A CD  1 
ATOM   614  C  CE  . LYS A 1 79  ? -3.942  -4.337  29.348  1    113.77 ? 75  LYS A CE  1 
ATOM   615  N  NZ  . LYS A 1 79  ? -3.287  -5.286  30.25   1    115.24 ? 75  LYS A NZ  1 
ATOM   616  N  N   . LEU A 1 80  ? -8.331  -5.265  24.489  1    59.42  ? 76  LEU A N   1 
ATOM   617  C  CA  . LEU A 1 80  ? -9.482  -5.931  23.855  1    53.9   ? 76  LEU A CA  1 
ATOM   618  C  C   . LEU A 1 80  ? -9.443  -7.379  24.337  1    52.24  ? 76  LEU A C   1 
ATOM   619  O  O   . LEU A 1 80  ? -8.453  -8.061  24.054  1    55.09  ? 76  LEU A O   1 
ATOM   620  C  CB  . LEU A 1 80  ? -9.316  -5.806  22.346  1    51.7   ? 76  LEU A CB  1 
ATOM   621  C  CG  . LEU A 1 80  ? -10.5   -6.235  21.479  1    49.61  ? 76  LEU A CG  1 
ATOM   622  C  CD1 . LEU A 1 80  ? -11.762 -5.604  22.006  1    50.82  ? 76  LEU A CD1 1 
ATOM   623  C  CD2 . LEU A 1 80  ? -10.242 -5.785  20.057  1    48.59  ? 76  LEU A CD2 1 
ATOM   624  N  N   . TYR A 1 81  ? -10.45  -7.797  25.095  1    51.19  ? 77  TYR A N   1 
ATOM   625  C  CA  . TYR A 1 81  ? -10.511 -9.198  25.522  1    50.39  ? 77  TYR A CA  1 
ATOM   626  C  C   . TYR A 1 81  ? -11.542 -9.958  24.684  1    48.19  ? 77  TYR A C   1 
ATOM   627  O  O   . TYR A 1 81  ? -12.688 -9.54   24.603  1    52.71  ? 77  TYR A O   1 
ATOM   628  C  CB  . TYR A 1 81  ? -10.885 -9.254  27.007  1    53.02  ? 77  TYR A CB  1 
ATOM   629  C  CG  . TYR A 1 81  ? -9.771  -8.878  27.97   1    59.6   ? 77  TYR A CG  1 
ATOM   630  C  CD1 . TYR A 1 81  ? -8.787  -9.8    28.318  1    62.31  ? 77  TYR A CD1 1 
ATOM   631  C  CD2 . TYR A 1 81  ? -9.676  -7.588  28.492  1    62.53  ? 77  TYR A CD2 1 
ATOM   632  C  CE1 . TYR A 1 81  ? -7.741  -9.444  29.161  1    72.39  ? 77  TYR A CE1 1 
ATOM   633  C  CE2 . TYR A 1 81  ? -8.648  -7.228  29.351  1    67.76  ? 77  TYR A CE2 1 
ATOM   634  C  CZ  . TYR A 1 81  ? -7.677  -8.161  29.693  1    75.5   ? 77  TYR A CZ  1 
ATOM   635  O  OH  . TYR A 1 81  ? -6.664  -7.812  30.555  1    85.8   ? 77  TYR A OH  1 
ATOM   636  N  N   . LEU A 1 82  ? -11.147 -11.042 24.024  1    44.65  ? 78  LEU A N   1 
ATOM   637  C  CA  . LEU A 1 82  ? -12.101 -11.939 23.394  1    44.07  ? 78  LEU A CA  1 
ATOM   638  C  C   . LEU A 1 82  ? -12.422 -13.059 24.379  1    47.76  ? 78  LEU A C   1 
ATOM   639  O  O   . LEU A 1 82  ? -11.518 -13.785 24.773  1    55.86  ? 78  LEU A O   1 
ATOM   640  C  CB  . LEU A 1 82  ? -11.54  -12.552 22.111  1    40.58  ? 78  LEU A CB  1 
ATOM   641  C  CG  . LEU A 1 82  ? -10.967 -11.587 21.071  1    41.91  ? 78  LEU A CG  1 
ATOM   642  C  CD1 . LEU A 1 82  ? -11.181 -12.138 19.683  1    37.66  ? 78  LEU A CD1 1 
ATOM   643  C  CD2 . LEU A 1 82  ? -11.507 -10.183 21.19   1    46.07  ? 78  LEU A CD2 1 
ATOM   644  N  N   . VAL A 1 83  ? -13.691 -13.211 24.778  1    47.26  ? 79  VAL A N   1 
ATOM   645  C  CA  . VAL A 1 83  ? -14.099 -14.302 25.664  1    45.37  ? 79  VAL A CA  1 
ATOM   646  C  C   . VAL A 1 83  ? -14.545 -15.493 24.812  1    45.8   ? 79  VAL A C   1 
ATOM   647  O  O   . VAL A 1 83  ? -15.497 -15.371 24.029  1    48.18  ? 79  VAL A O   1 
ATOM   648  C  CB  . VAL A 1 83  ? -15.267 -13.846 26.54   1    43.16  ? 79  VAL A CB  1 
ATOM   649  C  CG1 . VAL A 1 83  ? -15.587 -14.872 27.613  1    45.45  ? 79  VAL A CG1 1 
ATOM   650  C  CG2 . VAL A 1 83  ? -14.966 -12.494 27.143  1    44.43  ? 79  VAL A CG2 1 
ATOM   651  N  N   . PHE A 1 84  ? -13.862 -16.639 24.973  1    41.71  ? 80  PHE A N   1 
ATOM   652  C  CA  . PHE A 1 84  ? -14.205 -17.825 24.201  1    39.87  ? 80  PHE A CA  1 
ATOM   653  C  C   . PHE A 1 84  ? -14.66  -18.939 25.141  1    41.12  ? 80  PHE A C   1 
ATOM   654  O  O   . PHE A 1 84  ? -14.183 -19.065 26.258  1    47.25  ? 80  PHE A O   1 
ATOM   655  C  CB  . PHE A 1 84  ? -13.023 -18.357 23.395  1    39.45  ? 80  PHE A CB  1 
ATOM   656  C  CG  . PHE A 1 84  ? -12.525 -17.553 22.207  1    39.21  ? 80  PHE A CG  1 
ATOM   657  C  CD1 . PHE A 1 84  ? -13.096 -17.763 20.95   1    37.44  ? 80  PHE A CD1 1 
ATOM   658  C  CD2 . PHE A 1 84  ? -11.469 -16.641 22.324  1    37.61  ? 80  PHE A CD2 1 
ATOM   659  C  CE1 . PHE A 1 84  ? -12.634 -17.058 19.836  1    38.32  ? 80  PHE A CE1 1 
ATOM   660  C  CE2 . PHE A 1 84  ? -11.02  -15.938 21.214  1    42.3   ? 80  PHE A CE2 1 
ATOM   661  C  CZ  . PHE A 1 84  ? -11.589 -16.151 19.964  1    38.26  ? 80  PHE A CZ  1 
ATOM   662  N  N   . GLU A 1 85  ? -15.591 -19.759 24.667  1    40.32  ? 81  GLU A N   1 
ATOM   663  C  CA  . GLU A 1 85  ? -15.784 -21.115 25.144  1    40.11  ? 81  GLU A CA  1 
ATOM   664  C  C   . GLU A 1 85  ? -14.433 -21.794 25.368  1    43.13  ? 81  GLU A C   1 
ATOM   665  O  O   . GLU A 1 85  ? -13.574 -21.774 24.489  1    44.67  ? 81  GLU A O   1 
ATOM   666  C  CB  . GLU A 1 85  ? -16.455 -21.803 23.959  1    41.01  ? 81  GLU A CB  1 
ATOM   667  C  CG  . GLU A 1 85  ? -16.738 -23.284 24.165  1    47.36  ? 81  GLU A CG  1 
ATOM   668  C  CD  . GLU A 1 85  ? -17.073 -23.98  22.857  1    45.45  ? 81  GLU A CD  1 
ATOM   669  O  OE1 . GLU A 1 85  ? -17.422 -25.167 22.942  1    47.12  ? 81  GLU A OE1 1 
ATOM   670  O  OE2 . GLU A 1 85  ? -16.976 -23.357 21.783  1    46.28  ? 81  GLU A OE2 1 
ATOM   671  N  N   . PHE A 1 86  ? -14.27  -22.449 26.526  1    44.5   ? 82  PHE A N   1 
ATOM   672  C  CA  . PHE A 1 86  ? -13.008 -23.094 26.865  1    44.28  ? 82  PHE A CA  1 
ATOM   673  C  C   . PHE A 1 86  ? -13.009 -24.566 26.471  1    41.93  ? 82  PHE A C   1 
ATOM   674  O  O   . PHE A 1 86  ? -13.981 -25.263 26.745  1    43.54  ? 82  PHE A O   1 
ATOM   675  C  CB  . PHE A 1 86  ? -12.759 -23.023 28.37   1    45.58  ? 82  PHE A CB  1 
ATOM   676  C  CG  . PHE A 1 86  ? -11.57  -23.844 28.842  1    46.2   ? 82  PHE A CG  1 
ATOM   677  C  CD1 . PHE A 1 86  ? -10.26  -23.374 28.698  1    44.28  ? 82  PHE A CD1 1 
ATOM   678  C  CD2 . PHE A 1 86  ? -11.776 -25.105 29.412  1    45.02  ? 82  PHE A CD2 1 
ATOM   679  C  CE1 . PHE A 1 86  ? -9.191  -24.16  29.143  1    43.7   ? 82  PHE A CE1 1 
ATOM   680  C  CE2 . PHE A 1 86  ? -10.709 -25.871 29.87   1    41.95  ? 82  PHE A CE2 1 
ATOM   681  C  CZ  . PHE A 1 86  ? -9.421  -25.405 29.723  1    43.25  ? 82  PHE A CZ  1 
ATOM   682  N  N   . LEU A 1 87  ? -11.891 -25.022 25.885  1    43.04  ? 83  LEU A N   1 
ATOM   683  C  CA  . LEU A 1 87  ? -11.623 -26.421 25.562  1    44.35  ? 83  LEU A CA  1 
ATOM   684  C  C   . LEU A 1 87  ? -10.257 -26.815 26.131  1    47.56  ? 83  LEU A C   1 
ATOM   685  O  O   . LEU A 1 87  ? -9.281  -26.072 25.971  1    49.87  ? 83  LEU A O   1 
ATOM   686  C  CB  . LEU A 1 87  ? -11.72  -26.65  24.064  1    41.22  ? 83  LEU A CB  1 
ATOM   687  C  CG  . LEU A 1 87  ? -13.142 -26.65  23.487  1    45.29  ? 83  LEU A CG  1 
ATOM   688  C  CD1 . LEU A 1 87  ? -13.554 -25.281 22.973  1    41.94  ? 83  LEU A CD1 1 
ATOM   689  C  CD2 . LEU A 1 87  ? -13.301 -27.698 22.368  1    44.02  ? 83  LEU A CD2 1 
ATOM   690  N  N   A HIS A 1 88  ? -10.215 -27.99  26.765  0.5  47.5   ? 84  HIS A N   1 
ATOM   691  N  N   B HIS A 1 88  ? -10.193 -27.985 26.795  0.5  47.84  ? 84  HIS A N   1 
ATOM   692  C  CA  A HIS A 1 88  ? -9.116  -28.44  27.607  0.5  48.73  ? 84  HIS A CA  1 
ATOM   693  C  CA  B HIS A 1 88  ? -9.047  -28.384 27.615  0.5  49.26  ? 84  HIS A CA  1 
ATOM   694  C  C   A HIS A 1 88  ? -7.816  -28.633 26.804  0.5  48.61  ? 84  HIS A C   1 
ATOM   695  C  C   B HIS A 1 88  ? -7.774  -28.6   26.788  0.5  48.74  ? 84  HIS A C   1 
ATOM   696  O  O   A HIS A 1 88  ? -6.732  -28.382 27.322  0.5  46.74  ? 84  HIS A O   1 
ATOM   697  O  O   B HIS A 1 88  ? -6.674  -28.373 27.285  0.5  46.7   ? 84  HIS A O   1 
ATOM   698  C  CB  A HIS A 1 88  ? -9.608  -29.635 28.439  0.5  49.46  ? 84  HIS A CB  1 
ATOM   699  C  CB  B HIS A 1 88  ? -9.343  -29.601 28.512  0.5  50.63  ? 84  HIS A CB  1 
ATOM   700  C  CG  A HIS A 1 88  ? -11.089 -29.548 28.763  0.5  49.36  ? 84  HIS A CG  1 
ATOM   701  C  CG  B HIS A 1 88  ? -9.338  -30.918 27.799  0.5  51     ? 84  HIS A CG  1 
ATOM   702  N  ND1 A HIS A 1 88  ? -12.063 -29.805 27.816  0.5  45.8   ? 84  HIS A ND1 1 
ATOM   703  N  ND1 B HIS A 1 88  ? -8.342  -31.853 27.929  0.5  49.78  ? 84  HIS A ND1 1 
ATOM   704  C  CD2 A HIS A 1 88  ? -11.769 -29.241 29.891  0.5  49.78  ? 84  HIS A CD2 1 
ATOM   705  C  CD2 B HIS A 1 88  ? -10.224 -31.435 26.922  0.5  55.4   ? 84  HIS A CD2 1 
ATOM   706  C  CE1 A HIS A 1 88  ? -13.269 -29.682 28.339  0.5  44.91  ? 84  HIS A CE1 1 
ATOM   707  C  CE1 B HIS A 1 88  ? -8.619  -32.9   27.16   0.5  53.57  ? 84  HIS A CE1 1 
ATOM   708  N  NE2 A HIS A 1 88  ? -13.113 -29.299 29.589  0.5  49.24  ? 84  HIS A NE2 1 
ATOM   709  N  NE2 B HIS A 1 88  ? -9.765  -32.663 26.527  0.5  57.76  ? 84  HIS A NE2 1 
ATOM   710  N  N   . GLN A 1 89  ? -7.904  -29.051 25.535  1    46.45  ? 85  GLN A N   1 
ATOM   711  C  CA  . GLN A 1 89  ? -6.693  -29.422 24.807  1    47.26  ? 85  GLN A CA  1 
ATOM   712  C  C   . GLN A 1 89  ? -6.777  -29.138 23.311  1    44.51  ? 85  GLN A C   1 
ATOM   713  O  O   . GLN A 1 89  ? -7.85   -28.816 22.808  1    48.33  ? 85  GLN A O   1 
ATOM   714  C  CB  . GLN A 1 89  ? -6.513  -30.924 25.026  1    50.98  ? 85  GLN A CB  1 
ATOM   715  C  CG  . GLN A 1 89  ? -5.142  -31.408 24.572  1    54.14  ? 85  GLN A CG  1 
ATOM   716  C  CD  . GLN A 1 89  ? -4.82   -32.724 25.216  1    61.97  ? 85  GLN A CD  1 
ATOM   717  O  OE1 . GLN A 1 89  ? -3.796  -32.876 25.874  1    75.46  ? 85  GLN A OE1 1 
ATOM   718  N  NE2 . GLN A 1 89  ? -5.744  -33.662 25.098  1    75.2   ? 85  GLN A NE2 1 
ATOM   719  N  N   . ASP A 1 90  ? -5.635  -29.224 22.61   1    44     ? 86  ASP A N   1 
ATOM   720  C  CA  . ASP A 1 90  ? -5.577  -29.136 21.147  1    46.25  ? 86  ASP A CA  1 
ATOM   721  C  C   . ASP A 1 90  ? -5.153  -30.501 20.577  1    45.02  ? 86  ASP A C   1 
ATOM   722  O  O   . ASP A 1 90  ? -4.707  -31.353 21.332  1    42.82  ? 86  ASP A O   1 
ATOM   723  C  CB  . ASP A 1 90  ? -4.689  -27.994 20.674  1    46.51  ? 86  ASP A CB  1 
ATOM   724  C  CG  . ASP A 1 90  ? -3.215  -28.266 20.845  1    52.21  ? 86  ASP A CG  1 
ATOM   725  O  OD1 . ASP A 1 90  ? -2.748  -29.309 20.344  1    54.82  ? 86  ASP A OD1 1 
ATOM   726  O  OD2 . ASP A 1 90  ? -2.568  -27.447 21.489  1    68.44  ? 86  ASP A OD2 1 
ATOM   727  N  N   . LEU A 1 91  ? -5.289  -30.713 19.257  1    41.91  ? 87  LEU A N   1 
ATOM   728  C  CA  . LEU A 1 91  ? -5.13   -32.036 18.673  1    39.99  ? 87  LEU A CA  1 
ATOM   729  C  C   . LEU A 1 91  ? -3.654  -32.437 18.645  1    46.03  ? 87  LEU A C   1 
ATOM   730  O  O   . LEU A 1 91  ? -3.343  -33.627 18.762  1    50.03  ? 87  LEU A O   1 
ATOM   731  C  CB  . LEU A 1 91  ? -5.735  -32.073 17.278  1    39.33  ? 87  LEU A CB  1 
ATOM   732  C  CG  . LEU A 1 91  ? -5.587  -33.394 16.504  1    40.04  ? 87  LEU A CG  1 
ATOM   733  C  CD1 . LEU A 1 91  ? -6.381  -34.527 17.134  1    37.22  ? 87  LEU A CD1 1 
ATOM   734  C  CD2 . LEU A 1 91  ? -5.984  -33.238 15.046  1    35.62  ? 87  LEU A CD2 1 
ATOM   735  N  N   . LYS A 1 92  ? -2.752  -31.447 18.497  1    42.85  ? 88  LYS A N   1 
ATOM   736  C  CA  . LYS A 1 92  ? -1.315  -31.697 18.462  1    46.08  ? 88  LYS A CA  1 
ATOM   737  C  C   . LYS A 1 92  ? -0.841  -32.266 19.802  1    49.72  ? 88  LYS A C   1 
ATOM   738  O  O   . LYS A 1 92  ? -0.132  -33.281 19.817  1    53.61  ? 88  LYS A O   1 
ATOM   739  C  CB  . LYS A 1 92  ? -0.582  -30.429 18.006  1    48.63  ? 88  LYS A CB  1 
ATOM   740  C  CG  . LYS A 1 92  ? 0.857   -30.229 18.417  1    45.34  ? 88  LYS A CG  1 
ATOM   741  C  CD  . LYS A 1 92  ? 1.819   -31.367 18.147  1    60.23  ? 88  LYS A CD  1 
ATOM   742  C  CE  . LYS A 1 92  ? 1.768   -31.882 16.73   1    73.52  ? 88  LYS A CE  1 
ATOM   743  N  NZ  . LYS A 1 92  ? 2.933   -32.73  16.425  1    68.48  ? 88  LYS A NZ  1 
ATOM   744  N  N   . LYS A 1 93  ? -1.262  -31.632 20.911  1    44.85  ? 89  LYS A N   1 
ATOM   745  C  CA  . LYS A 1 93  ? -0.903  -32.059 22.256  1    52.26  ? 89  LYS A CA  1 
ATOM   746  C  C   . LYS A 1 93  ? -1.456  -33.453 22.559  1    54.17  ? 89  LYS A C   1 
ATOM   747  O  O   . LYS A 1 93  ? -0.777  -34.271 23.183  1    56.64  ? 89  LYS A O   1 
ATOM   748  C  CB  . LYS A 1 93  ? -1.328  -31.067 23.34   1    54.77  ? 89  LYS A CB  1 
ATOM   749  C  CG  . LYS A 1 93  ? -0.522  -29.798 23.344  1    73.82  ? 89  LYS A CG  1 
ATOM   750  C  CD  . LYS A 1 93  ? -0.742  -28.892 24.555  1    92.08  ? 89  LYS A CD  1 
ATOM   751  C  CE  . LYS A 1 93  ? 0.032   -27.602 24.437  1    92.03  ? 89  LYS A CE  1 
ATOM   752  N  NZ  . LYS A 1 93  ? -0.593  -26.514 25.189  1    100.38 ? 89  LYS A NZ  1 
ATOM   753  N  N   . PHE A 1 94  ? -2.682  -33.724 22.094  1    49.64  ? 90  PHE A N   1 
ATOM   754  C  CA  . PHE A 1 94  ? -3.322  -35.001 22.342  1    49.91  ? 90  PHE A CA  1 
ATOM   755  C  C   . PHE A 1 94  ? -2.548  -36.101 21.626  1    52.21  ? 90  PHE A C   1 
ATOM   756  O  O   . PHE A 1 94  ? -2.3    -37.152 22.205  1    53.7   ? 90  PHE A O   1 
ATOM   757  C  CB  . PHE A 1 94  ? -4.786  -34.94  21.917  1    46.31  ? 90  PHE A CB  1 
ATOM   758  C  CG  . PHE A 1 94  ? -5.5    -36.279 21.939  1    46.16  ? 90  PHE A CG  1 
ATOM   759  C  CD1 . PHE A 1 94  ? -5.808  -36.905 23.14   1    46.4   ? 90  PHE A CD1 1 
ATOM   760  C  CD2 . PHE A 1 94  ? -5.894  -36.878 20.744  1    45.21  ? 90  PHE A CD2 1 
ATOM   761  C  CE1 . PHE A 1 94  ? -6.46   -38.129 23.135  1    51.18  ? 90  PHE A CE1 1 
ATOM   762  C  CE2 . PHE A 1 94  ? -6.578  -38.085 20.738  1    47.15  ? 90  PHE A CE2 1 
ATOM   763  C  CZ  . PHE A 1 94  ? -6.857  -38.714 21.937  1    52.23  ? 90  PHE A CZ  1 
ATOM   764  N  N   . MET A 1 95  ? -2.148  -35.848 20.378  1    50.91  ? 91  MET A N   1 
ATOM   765  C  CA  . MET A 1 95  ? -1.404  -36.841 19.62   1    55.77  ? 91  MET A CA  1 
ATOM   766  C  C   . MET A 1 95  ? -0.037  -37.116 20.234  1    62.16  ? 91  MET A C   1 
ATOM   767  O  O   . MET A 1 95  ? 0.433   -38.24  20.156  1    71.57  ? 91  MET A O   1 
ATOM   768  C  CB  . MET A 1 95  ? -1.249  -36.405 18.164  1    51.32  ? 91  MET A CB  1 
ATOM   769  C  CG  . MET A 1 95  ? -2.464  -36.688 17.35   1    49.54  ? 91  MET A CG  1 
ATOM   770  S  SD  . MET A 1 95  ? -2.144  -36.208 15.649  1    66.12  ? 91  MET A SD  1 
ATOM   771  C  CE  . MET A 1 95  ? -1.929  -34.428 15.803  1    48.52  ? 91  MET A CE  1 
ATOM   772  N  N   . ASP A 1 96  ? 0.58    -36.091 20.844  1    64.64  ? 92  ASP A N   1 
ATOM   773  C  CA  . ASP A 1 96  ? 1.846   -36.238 21.545  1    63.01  ? 92  ASP A CA  1 
ATOM   774  C  C   . ASP A 1 96  ? 1.65    -37.081 22.799  1    66.85  ? 92  ASP A C   1 
ATOM   775  O  O   . ASP A 1 96  ? 2.581   -37.758 23.204  1    72.74  ? 92  ASP A O   1 
ATOM   776  C  CB  . ASP A 1 96  ? 2.492   -34.885 21.809  1    63.01  ? 92  ASP A CB  1 
ATOM   777  C  CG  . ASP A 1 96  ? 2.839   -34.08  20.56   1    64.82  ? 92  ASP A CG  1 
ATOM   778  O  OD1 . ASP A 1 96  ? 3.068   -34.71  19.469  1    57.63  ? 92  ASP A OD1 1 
ATOM   779  O  OD2 . ASP A 1 96  ? 2.822   -32.823 20.675  1    65.64  ? 92  ASP A OD2 1 
ATOM   780  N  N   . ALA A 1 97  ? 0.436   -37.055 23.383  1    75.73  ? 93  ALA A N   1 
ATOM   781  C  CA  . ALA A 1 97  ? 0.041   -37.918 24.501  1    70.17  ? 93  ALA A CA  1 
ATOM   782  C  C   . ALA A 1 97  ? -0.653  -39.22  24.054  1    74.51  ? 93  ALA A C   1 
ATOM   783  O  O   . ALA A 1 97  ? -0.804  -40.099 24.885  1    72.61  ? 93  ALA A O   1 
ATOM   784  C  CB  . ALA A 1 97  ? -0.856  -37.144 25.41   1    65.61  ? 93  ALA A CB  1 
ATOM   785  N  N   . SER A 1 98  ? -1.076  -39.311 22.785  1    76.98  ? 94  SER A N   1 
ATOM   786  C  CA  . SER A 1 98  ? -1.621  -40.58  22.231  1    69.94  ? 94  SER A CA  1 
ATOM   787  C  C   . SER A 1 98  ? -0.4    -41.46  21.995  1    90.84  ? 94  SER A C   1 
ATOM   788  O  O   . SER A 1 98  ? -0.499  -42.418 21.203  1    78.55  ? 94  SER A O   1 
ATOM   789  C  CB  . SER A 1 98  ? -2.386  -40.38  20.97   1    61.93  ? 94  SER A CB  1 
ATOM   790  O  OG  . SER A 1 98  ? -3.508  -39.541 21.189  1    88.63  ? 94  SER A OG  1 
ATOM   791  N  N   . ALA A 1 99  ? 0.722   -41.073 22.602  1    107.86 ? 95  ALA A N   1 
ATOM   792  C  CA  . ALA A 1 99  ? 1.961   -41.88  22.569  1    96.34  ? 95  ALA A CA  1 
ATOM   793  C  C   . ALA A 1 99  ? 2.115   -42.681 21.282  1    101.69 ? 95  ALA A C   1 
ATOM   794  O  O   . ALA A 1 99  ? 2.157   -42.093 20.179  1    96.04  ? 95  ALA A O   1 
ATOM   795  C  CB  . ALA A 1 99  ? 1.944   -42.791 23.768  1    87.6   ? 95  ALA A CB  1 
ATOM   796  N  N   . LEU A 1 100 ? 2.261   -43.992 21.435  1    108.28 ? 96  LEU A N   1 
ATOM   797  C  CA  . LEU A 1 100 ? 2.498   -44.845 20.252  1    125.41 ? 96  LEU A CA  1 
ATOM   798  C  C   . LEU A 1 100 ? 1.226   -45.646 20.006  1    122.59 ? 96  LEU A C   1 
ATOM   799  O  O   . LEU A 1 100 ? 0.938   -45.937 18.835  1    150.08 ? 96  LEU A O   1 
ATOM   800  C  CB  . LEU A 1 100 ? 3.702   -45.753 20.494  1    140.46 ? 96  LEU A CB  1 
ATOM   801  C  CG  . LEU A 1 100 ? 5.04    -45.041 20.71   1    142.02 ? 96  LEU A CG  1 
ATOM   802  C  CD1 . LEU A 1 100 ? 6.14    -46.044 21.005  1    134.04 ? 96  LEU A CD1 1 
ATOM   803  C  CD2 . LEU A 1 100 ? 5.395   -44.191 19.503  1    124.75 ? 96  LEU A CD2 1 
ATOM   804  N  N   . THR A 1 101 ? 0.519   -46.001 21.073  1    103.32 ? 97  THR A N   1 
ATOM   805  C  CA  . THR A 1 101 ? -0.771  -46.674 20.88   1    107.05 ? 97  THR A CA  1 
ATOM   806  C  C   . THR A 1 101 ? -1.38   -46.134 19.621  1    95.48  ? 97  THR A C   1 
ATOM   807  O  O   . THR A 1 101 ? -1.78   -46.933 18.752  1    79.4   ? 97  THR A O   1 
ATOM   808  C  CB  . THR A 1 101 ? -1.648  -46.325 22.077  1    122.17 ? 97  THR A CB  1 
ATOM   809  O  OG1 . THR A 1 101 ? -1.77   -44.907 22.102  1    133.12 ? 97  THR A OG1 1 
ATOM   810  C  CG2 . THR A 1 101 ? -1.043  -46.777 23.394  1    103.06 ? 97  THR A CG2 1 
ATOM   811  N  N   . GLY A 1 102 ? -1.463  -44.813 19.533  1    83.78  ? 98  GLY A N   1 
ATOM   812  C  CA  . GLY A 1 102 ? -2.118  -44.189 18.406  1    72.88  ? 98  GLY A CA  1 
ATOM   813  C  C   . GLY A 1 102 ? -3.518  -43.731 18.792  1    67.58  ? 98  GLY A C   1 
ATOM   814  O  O   . GLY A 1 102 ? -3.913  -43.894 19.944  1    67.85  ? 98  GLY A O   1 
ATOM   815  N  N   . ILE A 1 103 ? -4.227  -43.116 17.841  1    64.33  ? 99  ILE A N   1 
ATOM   816  C  CA  . ILE A 1 103 ? -5.628  -42.78  18.042  1    57.35  ? 99  ILE A CA  1 
ATOM   817  C  C   . ILE A 1 103 ? -6.455  -43.926 17.472  1    51.92  ? 99  ILE A C   1 
ATOM   818  O  O   . ILE A 1 103 ? -6.263  -44.322 16.334  1    54.04  ? 99  ILE A O   1 
ATOM   819  C  CB  . ILE A 1 103 ? -5.98   -41.419 17.414  1    56.02  ? 99  ILE A CB  1 
ATOM   820  C  CG1 . ILE A 1 103 ? -5.036  -40.308 17.87   1    57.44  ? 99  ILE A CG1 1 
ATOM   821  C  CG2 . ILE A 1 103 ? -7.432  -41.047 17.712  1    53.6   ? 99  ILE A CG2 1 
ATOM   822  C  CD1 . ILE A 1 103 ? -5.328  -38.968 17.206  1    59.01  ? 99  ILE A CD1 1 
ATOM   823  N  N   . PRO A 1 104 ? -7.388  -44.505 18.252  1    50.28  ? 100 PRO A N   1 
ATOM   824  C  CA  . PRO A 1 104 ? -8.258  -45.577 17.747  1    49.37  ? 100 PRO A CA  1 
ATOM   825  C  C   . PRO A 1 104 ? -9.102  -45.097 16.565  1    49.09  ? 100 PRO A C   1 
ATOM   826  O  O   . PRO A 1 104 ? -9.498  -43.935 16.482  1    45.29  ? 100 PRO A O   1 
ATOM   827  C  CB  . PRO A 1 104 ? -9.082  -45.965 18.985  1    52.55  ? 100 PRO A CB  1 
ATOM   828  C  CG  . PRO A 1 104 ? -9.046  -44.707 19.827  1    55.09  ? 100 PRO A CG  1 
ATOM   829  C  CD  . PRO A 1 104 ? -7.656  -44.121 19.643  1    50.65  ? 100 PRO A CD  1 
ATOM   830  N  N   . LEU A 1 105 ? -9.326  -46.002 15.609  1    56.34  ? 101 LEU A N   1 
ATOM   831  C  CA  . LEU A 1 105 ? -9.993  -45.69  14.344  1    53.73  ? 101 LEU A CA  1 
ATOM   832  C  C   . LEU A 1 105 ? -11.371 -45.05  14.575  1    53.16  ? 101 LEU A C   1 
ATOM   833  O  O   . LEU A 1 105 ? -11.663 -44.054 13.925  1    52.59  ? 101 LEU A O   1 
ATOM   834  C  CB  . LEU A 1 105 ? -10.032 -46.976 13.522  1    54.3   ? 101 LEU A CB  1 
ATOM   835  C  CG  . LEU A 1 105 ? -10.741 -46.962 12.167  1    56.64  ? 101 LEU A CG  1 
ATOM   836  C  CD1 . LEU A 1 105 ? -9.963  -45.978 11.307  1    69.85  ? 101 LEU A CD1 1 
ATOM   837  C  CD2 . LEU A 1 105 ? -10.904 -48.307 11.487  1    48.79  ? 101 LEU A CD2 1 
ATOM   838  N  N   . PRO A 1 106 ? -12.217 -45.515 15.542  1    52.39  ? 102 PRO A N   1 
ATOM   839  C  CA  . PRO A 1 106 ? -13.451 -44.816 15.91   1    47.09  ? 102 PRO A CA  1 
ATOM   840  C  C   . PRO A 1 106 ? -13.302 -43.328 16.154  1    46.5   ? 102 PRO A C   1 
ATOM   841  O  O   . PRO A 1 106 ? -14.161 -42.569 15.712  1    49.06  ? 102 PRO A O   1 
ATOM   842  C  CB  . PRO A 1 106 ? -13.938 -45.529 17.194  1    49.67  ? 102 PRO A CB  1 
ATOM   843  C  CG  . PRO A 1 106 ? -13.408 -46.946 17.02   1    49.33  ? 102 PRO A CG  1 
ATOM   844  C  CD  . PRO A 1 106 ? -12.059 -46.756 16.338  1    50.79  ? 102 PRO A CD  1 
ATOM   845  N  N   . LEU A 1 107 ? -12.228 -42.922 16.856  1    47.45  ? 103 LEU A N   1 
ATOM   846  C  CA  . LEU A 1 107 ? -12.018 -41.543 17.296  1    42.15  ? 103 LEU A CA  1 
ATOM   847  C  C   . LEU A 1 107 ? -11.471 -40.687 16.158  1    42.35  ? 103 LEU A C   1 
ATOM   848  O  O   . LEU A 1 107 ? -11.762 -39.503 16.067  1    43.04  ? 103 LEU A O   1 
ATOM   849  C  CB  . LEU A 1 107 ? -11.083 -41.535 18.493  1    41.43  ? 103 LEU A CB  1 
ATOM   850  C  CG  . LEU A 1 107 ? -10.952 -40.238 19.303  1    44.23  ? 103 LEU A CG  1 
ATOM   851  C  CD1 . LEU A 1 107 ? -12.305 -39.663 19.706  1    45.48  ? 103 LEU A CD1 1 
ATOM   852  C  CD2 . LEU A 1 107 ? -10.174 -40.586 20.602  1    43.47  ? 103 LEU A CD2 1 
ATOM   853  N  N   . ILE A 1 108 ? -10.67  -41.283 15.273  1    45.52  ? 104 ILE A N   1 
ATOM   854  C  CA  . ILE A 1 108 ? -10.156 -40.556 14.121  1    47.52  ? 104 ILE A CA  1 
ATOM   855  C  C   . ILE A 1 108 ? -11.334 -40.159 13.223  1    44.16  ? 104 ILE A C   1 
ATOM   856  O  O   . ILE A 1 108 ? -11.443 -39.043 12.696  1    43.16  ? 104 ILE A O   1 
ATOM   857  C  CB  . ILE A 1 108 ? -9.144  -41.444 13.367  1    49.21  ? 104 ILE A CB  1 
ATOM   858  C  CG1 . ILE A 1 108 ? -7.854  -41.645 14.174  1    48.4   ? 104 ILE A CG1 1 
ATOM   859  C  CG2 . ILE A 1 108 ? -8.861  -40.884 11.966  1    44.99  ? 104 ILE A CG2 1 
ATOM   860  C  CD1 . ILE A 1 108 ? -6.831  -42.567 13.493  1    45.96  ? 104 ILE A CD1 1 
ATOM   861  N  N   . LYS A 1 109 ? -12.209 -41.135 13.038  1    42.32  ? 105 LYS A N   1 
ATOM   862  C  CA  . LYS A 1 109 ? -13.342 -41.038 12.142  1    45.74  ? 105 LYS A CA  1 
ATOM   863  C  C   . LYS A 1 109 ? -14.316 -39.976 12.666  1    44.21  ? 105 LYS A C   1 
ATOM   864  O  O   . LYS A 1 109 ? -14.783 -39.127 11.903  1    38.12  ? 105 LYS A O   1 
ATOM   865  C  CB  . LYS A 1 109 ? -13.881 -42.472 12.096  1    45.93  ? 105 LYS A CB  1 
ATOM   866  C  CG  . LYS A 1 109 ? -14.793 -42.775 10.953  1    51.11  ? 105 LYS A CG  1 
ATOM   867  C  CD  . LYS A 1 109 ? -15.141 -44.263 10.971  1    55.15  ? 105 LYS A CD  1 
ATOM   868  C  CE  . LYS A 1 109 ? -14.043 -45.077 10.366  1    51.02  ? 105 LYS A CE  1 
ATOM   869  N  NZ  . LYS A 1 109 ? -14.569 -46.373 9.918   1    49.39  ? 105 LYS A NZ  1 
ATOM   870  N  N   . SER A 1 110 ? -14.571 -40.02  13.985  1    43.38  ? 106 SER A N   1 
ATOM   871  C  CA  . SER A 1 110 ? -15.375 -39.027 14.683  1    47.3   ? 106 SER A CA  1 
ATOM   872  C  C   . SER A 1 110 ? -14.797 -37.624 14.532  1    41.34  ? 106 SER A C   1 
ATOM   873  O  O   . SER A 1 110 ? -15.532 -36.673 14.271  1    42.15  ? 106 SER A O   1 
ATOM   874  C  CB  . SER A 1 110 ? -15.544 -39.376 16.142  1    49.76  ? 106 SER A CB  1 
ATOM   875  O  OG  . SER A 1 110 ? -15.984 -38.229 16.856  1    50.99  ? 106 SER A OG  1 
ATOM   876  N  N   . TYR A 1 111 ? -13.483 -37.5   14.716  1    40.87  ? 107 TYR A N   1 
ATOM   877  C  CA  . TYR A 1 111 ? -12.83  -36.202 14.674  1    42.79  ? 107 TYR A CA  1 
ATOM   878  C  C   . TYR A 1 111 ? -12.893 -35.646 13.25   1    44.21  ? 107 TYR A C   1 
ATOM   879  O  O   . TYR A 1 111 ? -13.241 -34.481 13.06   1    42.3   ? 107 TYR A O   1 
ATOM   880  C  CB  . TYR A 1 111 ? -11.393 -36.293 15.193  1    44.62  ? 107 TYR A CB  1 
ATOM   881  C  CG  . TYR A 1 111 ? -11.182 -36.26  16.703  1    51.81  ? 107 TYR A CG  1 
ATOM   882  C  CD1 . TYR A 1 111 ? -12.228 -35.983 17.595  1    53.75  ? 107 TYR A CD1 1 
ATOM   883  C  CD2 . TYR A 1 111 ? -9.92   -36.511 17.244  1    51.57  ? 107 TYR A CD2 1 
ATOM   884  C  CE1 . TYR A 1 111 ? -12.008 -35.94  18.967  1    53.61  ? 107 TYR A CE1 1 
ATOM   885  C  CE2 . TYR A 1 111 ? -9.691  -36.469 18.613  1    48.2   ? 107 TYR A CE2 1 
ATOM   886  C  CZ  . TYR A 1 111 ? -10.74  -36.191 19.466  1    52.23  ? 107 TYR A CZ  1 
ATOM   887  O  OH  . TYR A 1 111 ? -10.553 -36.138 20.801  1    58.46  ? 107 TYR A OH  1 
ATOM   888  N  N   . LEU A 1 112 ? -12.591 -36.505 12.263  1    40.29  ? 108 LEU A N   1 
ATOM   889  C  CA  . LEU A 1 112 ? -12.545 -36.059 10.887  1    38.13  ? 108 LEU A CA  1 
ATOM   890  C  C   . LEU A 1 112 ? -13.943 -35.616 10.438  1    39.66  ? 108 LEU A C   1 
ATOM   891  O  O   . LEU A 1 112 ? -14.104 -34.606 9.716   1    37.61  ? 108 LEU A O   1 
ATOM   892  C  CB  . LEU A 1 112 ? -11.926 -37.112 9.966   1    33.57  ? 108 LEU A CB  1 
ATOM   893  C  CG  . LEU A 1 112 ? -11.733 -36.629 8.522   1    30.86  ? 108 LEU A CG  1 
ATOM   894  C  CD1 . LEU A 1 112 ? -10.844 -35.362 8.47    1    27.41  ? 108 LEU A CD1 1 
ATOM   895  C  CD2 . LEU A 1 112 ? -11.21  -37.728 7.602   1    29.36  ? 108 LEU A CD2 1 
ATOM   896  N  N   . PHE A 1 113 ? -14.945 -36.39  10.887  1    37.92  ? 109 PHE A N   1 
ATOM   897  C  CA  . PHE A 1 113 ? -16.331 -36.119 10.549  1    36.83  ? 109 PHE A CA  1 
ATOM   898  C  C   . PHE A 1 113 ? -16.78  -34.792 11.155  1    39.39  ? 109 PHE A C   1 
ATOM   899  O  O   . PHE A 1 113 ? -17.335 -33.96  10.44   1    43.92  ? 109 PHE A O   1 
ATOM   900  C  CB  . PHE A 1 113 ? -17.197 -37.281 10.996  1    40.87  ? 109 PHE A CB  1 
ATOM   901  C  CG  . PHE A 1 113 ? -18.616 -37.237 10.428  1    46.14  ? 109 PHE A CG  1 
ATOM   902  C  CD1 . PHE A 1 113 ? -18.838 -37.449 9.072   1    41.79  ? 109 PHE A CD1 1 
ATOM   903  C  CD2 . PHE A 1 113 ? -19.709 -37.039 11.262  1    44.78  ? 109 PHE A CD2 1 
ATOM   904  C  CE1 . PHE A 1 113 ? -20.106 -37.442 8.568   1    41.4   ? 109 PHE A CE1 1 
ATOM   905  C  CE2 . PHE A 1 113 ? -20.987 -37.07  10.756  1    47.39  ? 109 PHE A CE2 1 
ATOM   906  C  CZ  . PHE A 1 113 ? -21.176 -37.283 9.418   1    48.02  ? 109 PHE A CZ  1 
ATOM   907  N  N   . GLN A 1 114 ? -16.459 -34.542 12.44   1    40.3   ? 110 GLN A N   1 
ATOM   908  C  CA  . GLN A 1 114 ? -16.757 -33.241 13.033  1    36.89  ? 110 GLN A CA  1 
ATOM   909  C  C   . GLN A 1 114 ? -15.997 -32.101 12.348  1    38.1   ? 110 GLN A C   1 
ATOM   910  O  O   . GLN A 1 114 ? -16.543 -31.002 12.223  1    38.58  ? 110 GLN A O   1 
ATOM   911  C  CB  . GLN A 1 114 ? -16.458 -33.219 14.518  1    34.13  ? 110 GLN A CB  1 
ATOM   912  C  CG  . GLN A 1 114 ? -17.332 -34.154 15.332  1    35.81  ? 110 GLN A CG  1 
ATOM   913  C  CD  . GLN A 1 114 ? -16.874 -34.144 16.771  1    40.97  ? 110 GLN A CD  1 
ATOM   914  O  OE1 . GLN A 1 114 ? -17.017 -33.123 17.472  1    42.61  ? 110 GLN A OE1 1 
ATOM   915  N  NE2 . GLN A 1 114 ? -16.277 -35.253 17.21   1    36.8   ? 110 GLN A NE2 1 
ATOM   916  N  N   . LEU A 1 115 ? -14.737 -32.34  11.943  1    35.41  ? 111 LEU A N   1 
ATOM   917  C  CA  . LEU A 1 115 ? -13.936 -31.285 11.338  1    37.19  ? 111 LEU A CA  1 
ATOM   918  C  C   . LEU A 1 115 ? -14.564 -30.842 10.015  1    39.69  ? 111 LEU A C   1 
ATOM   919  O  O   . LEU A 1 115 ? -14.633 -29.647 9.717   1    36.07  ? 111 LEU A O   1 
ATOM   920  C  CB  . LEU A 1 115 ? -12.507 -31.759 11.121  1    35.5   ? 111 LEU A CB  1 
ATOM   921  C  CG  . LEU A 1 115 ? -11.665 -31.839 12.399  1    38.24  ? 111 LEU A CG  1 
ATOM   922  C  CD1 . LEU A 1 115 ? -10.295 -32.434 12.134  1    34.72  ? 111 LEU A CD1 1 
ATOM   923  C  CD2 . LEU A 1 115 ? -11.539 -30.476 13.039  1    36.7   ? 111 LEU A CD2 1 
ATOM   924  N  N   . LEU A 1 116 ? -15.052 -31.821 9.245   1    38.4   ? 112 LEU A N   1 
ATOM   925  C  CA  . LEU A 1 116 ? -15.698 -31.552 7.964   1    39.45  ? 112 LEU A CA  1 
ATOM   926  C  C   . LEU A 1 116 ? -16.99  -30.763 8.155   1    38.79  ? 112 LEU A C   1 
ATOM   927  O  O   . LEU A 1 116 ? -17.27  -29.858 7.368   1    40.08  ? 112 LEU A O   1 
ATOM   928  C  CB  . LEU A 1 116 ? -15.908 -32.863 7.205   1    35.87  ? 112 LEU A CB  1 
ATOM   929  C  CG  . LEU A 1 116 ? -14.597 -33.469 6.697   1    34.26  ? 112 LEU A CG  1 
ATOM   930  C  CD1 . LEU A 1 116 ? -14.68  -34.955 6.494   1    32.64  ? 112 LEU A CD1 1 
ATOM   931  C  CD2 . LEU A 1 116 ? -14.164 -32.768 5.415   1    34.99  ? 112 LEU A CD2 1 
ATOM   932  N  N   . GLN A 1 117 ? -17.75  -31.084 9.212   1    37.77  ? 113 GLN A N   1 
ATOM   933  C  CA  . GLN A 1 117 ? -18.965 -30.344 9.517   1    38.68  ? 113 GLN A CA  1 
ATOM   934  C  C   . GLN A 1 117 ? -18.621 -28.875 9.734   1    38.82  ? 113 GLN A C   1 
ATOM   935  O  O   . GLN A 1 117 ? -19.268 -27.987 9.172   1    41.04  ? 113 GLN A O   1 
ATOM   936  C  CB  . GLN A 1 117 ? -19.691 -30.855 10.758  1    39.08  ? 113 GLN A CB  1 
ATOM   937  C  CG  . GLN A 1 117 ? -20.27  -32.253 10.572  1    39.36  ? 113 GLN A CG  1 
ATOM   938  C  CD  . GLN A 1 117 ? -21.078 -32.716 11.771  1    41.27  ? 113 GLN A CD  1 
ATOM   939  O  OE1 . GLN A 1 117 ? -21.984 -32.048 12.307  1    38.91  ? 113 GLN A OE1 1 
ATOM   940  N  NE2 . GLN A 1 117 ? -20.761 -33.928 12.168  1    42.31  ? 113 GLN A NE2 1 
ATOM   941  N  N   . GLY A 1 118 ? -17.588 -28.64  10.55   1    40.17  ? 114 GLY A N   1 
ATOM   942  C  CA  . GLY A 1 118 ? -17.171 -27.297 10.915  1    36.74  ? 114 GLY A CA  1 
ATOM   943  C  C   . GLY A 1 118 ? -16.742 -26.532 9.676   1    35.85  ? 114 GLY A C   1 
ATOM   944  O  O   . GLY A 1 118 ? -17.101 -25.369 9.477   1    35.68  ? 114 GLY A O   1 
ATOM   945  N  N   . LEU A 1 119 ? -15.993 -27.22  8.823   1    38.02  ? 115 LEU A N   1 
ATOM   946  C  CA  . LEU A 1 119 ? -15.424 -26.552 7.671   1    37.72  ? 115 LEU A CA  1 
ATOM   947  C  C   . LEU A 1 119 ? -16.506 -26.286 6.637   1    39.75  ? 115 LEU A C   1 
ATOM   948  O  O   . LEU A 1 119 ? -16.503 -25.222 6.001   1    43.72  ? 115 LEU A O   1 
ATOM   949  C  CB  . LEU A 1 119 ? -14.307 -27.42  7.119   1    34.42  ? 115 LEU A CB  1 
ATOM   950  C  CG  . LEU A 1 119 ? -13.584 -26.815 5.923   1    37.31  ? 115 LEU A CG  1 
ATOM   951  C  CD1 . LEU A 1 119 ? -13.006 -25.459 6.292   1    37.62  ? 115 LEU A CD1 1 
ATOM   952  C  CD2 . LEU A 1 119 ? -12.485 -27.777 5.496   1    32.92  ? 115 LEU A CD2 1 
ATOM   953  N  N   . ALA A 1 120 ? -17.383 -27.285 6.434   1    36.39  ? 116 ALA A N   1 
ATOM   954  C  CA  . ALA A 1 120 ? -18.504 -27.119 5.521   1    37.58  ? 116 ALA A CA  1 
ATOM   955  C  C   . ALA A 1 120 ? -19.294 -25.869 5.946   1    39.43  ? 116 ALA A C   1 
ATOM   956  O  O   . ALA A 1 120 ? -19.662 -25.044 5.119   1    38.89  ? 116 ALA A O   1 
ATOM   957  C  CB  . ALA A 1 120 ? -19.337 -28.379 5.503   1    31.1   ? 116 ALA A CB  1 
ATOM   958  N  N   . PHE A 1 121 ? -19.54  -25.72  7.258   1    35.49  ? 117 PHE A N   1 
ATOM   959  C  CA  . PHE A 1 121 ? -20.226 -24.559 7.797   1    34.73  ? 117 PHE A CA  1 
ATOM   960  C  C   . PHE A 1 121 ? -19.502 -23.256 7.431   1    36.37  ? 117 PHE A C   1 
ATOM   961  O  O   . PHE A 1 121 ? -20.165 -22.289 7.086   1    39.6   ? 117 PHE A O   1 
ATOM   962  C  CB  . PHE A 1 121 ? -20.446 -24.705 9.303   1    32.83  ? 117 PHE A CB  1 
ATOM   963  C  CG  . PHE A 1 121 ? -21.409 -23.653 9.818   1    39.28  ? 117 PHE A CG  1 
ATOM   964  C  CD1 . PHE A 1 121 ? -20.957 -22.367 10.151  1    40.23  ? 117 PHE A CD1 1 
ATOM   965  C  CD2 . PHE A 1 121 ? -22.779 -23.918 9.881   1    39.02  ? 117 PHE A CD2 1 
ATOM   966  C  CE1 . PHE A 1 121 ? -21.855 -21.381 10.562  1    39.96  ? 117 PHE A CE1 1 
ATOM   967  C  CE2 . PHE A 1 121 ? -23.661 -22.942 10.332  1    38.72  ? 117 PHE A CE2 1 
ATOM   968  C  CZ  . PHE A 1 121 ? -23.205 -21.687 10.69   1    37.12  ? 117 PHE A CZ  1 
ATOM   969  N  N   . CYS A 1 122 ? -18.159 -23.229 7.498   1    36.09  ? 118 CYS A N   1 
ATOM   970  C  CA  . CYS A 1 122 ? -17.366 -22.048 7.174   1    36.1   ? 118 CYS A CA  1 
ATOM   971  C  C   . CYS A 1 122 ? -17.533 -21.665 5.702   1    39.63  ? 118 CYS A C   1 
ATOM   972  O  O   . CYS A 1 122 ? -17.79  -20.499 5.392   1    41.21  ? 118 CYS A O   1 
ATOM   973  C  CB  . CYS A 1 122 ? -15.872 -22.27  7.415   1    35.54  ? 118 CYS A CB  1 
ATOM   974  S  SG  . CYS A 1 122 ? -15.419 -22.347 9.167   1    39.09  ? 118 CYS A SG  1 
ATOM   975  N  N   . HIS A 1 123 ? -17.365 -22.658 4.813   1    35.97  ? 119 HIS A N   1 
ATOM   976  C  CA  . HIS A 1 123 ? -17.459 -22.431 3.389   1    35.66  ? 119 HIS A CA  1 
ATOM   977  C  C   . HIS A 1 123 ? -18.875 -21.988 3.015   1    39.37  ? 119 HIS A C   1 
ATOM   978  O  O   . HIS A 1 123 ? -19.063 -21.184 2.088   1    44.25  ? 119 HIS A O   1 
ATOM   979  C  CB  . HIS A 1 123 ? -16.99  -23.688 2.653   1    34.85  ? 119 HIS A CB  1 
ATOM   980  C  CG  . HIS A 1 123 ? -15.55  -23.981 2.912   1    39.52  ? 119 HIS A CG  1 
ATOM   981  N  ND1 . HIS A 1 123 ? -14.926 -25.167 2.57    1    36.49  ? 119 HIS A ND1 1 
ATOM   982  C  CD2 . HIS A 1 123 ? -14.594 -23.185 3.474   1    35.6   ? 119 HIS A CD2 1 
ATOM   983  C  CE1 . HIS A 1 123 ? -13.649 -25.075 2.943   1    40.04  ? 119 HIS A CE1 1 
ATOM   984  N  NE2 . HIS A 1 123 ? -13.421 -23.881 3.486   1    33.91  ? 119 HIS A NE2 1 
ATOM   985  N  N   . SER A 1 124 ? -19.862 -22.519 3.732   1    33.26  ? 120 SER A N   1 
ATOM   986  C  CA  . SER A 1 124 ? -21.251 -22.191 3.475   1    40.68  ? 120 SER A CA  1 
ATOM   987  C  C   . SER A 1 124 ? -21.552 -20.75  3.868   1    39.47  ? 120 SER A C   1 
ATOM   988  O  O   . SER A 1 124 ? -22.562 -20.206 3.422   1    42.11  ? 120 SER A O   1 
ATOM   989  C  CB  . SER A 1 124 ? -22.19  -23.126 4.212   1    42.7   ? 120 SER A CB  1 
ATOM   990  O  OG  . SER A 1 124 ? -22.134 -24.433 3.655   1    44.42  ? 120 SER A OG  1 
ATOM   991  N  N   . HIS A 1 125 ? -20.703 -20.183 4.738   1    36.36  ? 121 HIS A N   1 
ATOM   992  C  CA  . HIS A 1 125 ? -20.819 -18.812 5.206   1    38.39  ? 121 HIS A CA  1 
ATOM   993  C  C   . HIS A 1 125 ? -19.73  -17.909 4.613   1    40.11  ? 121 HIS A C   1 
ATOM   994  O  O   . HIS A 1 125 ? -19.417 -16.882 5.193   1    39.49  ? 121 HIS A O   1 
ATOM   995  C  CB  . HIS A 1 125 ? -20.803 -18.824 6.733   1    38.71  ? 121 HIS A CB  1 
ATOM   996  C  CG  . HIS A 1 125 ? -22.077 -19.411 7.206   1    40.94  ? 121 HIS A CG  1 
ATOM   997  N  ND1 . HIS A 1 125 ? -22.318 -20.756 7.089   1    40.39  ? 121 HIS A ND1 1 
ATOM   998  C  CD2 . HIS A 1 125 ? -23.202 -18.875 7.677   1    42.51  ? 121 HIS A CD2 1 
ATOM   999  C  CE1 . HIS A 1 125 ? -23.552 -21.009 7.51    1    43.14  ? 121 HIS A CE1 1 
ATOM   1000 N  NE2 . HIS A 1 125 ? -24.101 -19.888 7.848   1    42.66  ? 121 HIS A NE2 1 
ATOM   1001 N  N   . ARG A 1 126 ? -19.172 -18.294 3.456   1    36.26  ? 122 ARG A N   1 
ATOM   1002 C  CA  . ARG A 1 126 ? -18.178 -17.529 2.723   1    35.89  ? 122 ARG A CA  1 
ATOM   1003 C  C   . ARG A 1 126 ? -16.947 -17.182 3.572   1    37.79  ? 122 ARG A C   1 
ATOM   1004 O  O   . ARG A 1 126 ? -16.378 -16.117 3.375   1    38.97  ? 122 ARG A O   1 
ATOM   1005 C  CB  . ARG A 1 126 ? -18.832 -16.341 2.008   1    36.64  ? 122 ARG A CB  1 
ATOM   1006 C  CG  . ARG A 1 126 ? -19.604 -15.347 2.867   1    36.48  ? 122 ARG A CG  1 
ATOM   1007 C  CD  . ARG A 1 126 ? -18.761 -14.209 3.351   1    39.39  ? 122 ARG A CD  1 
ATOM   1008 N  NE  . ARG A 1 126 ? -19.544 -13.198 4.079   1    53.33  ? 122 ARG A NE  1 
ATOM   1009 C  CZ  . ARG A 1 126 ? -19.886 -13.22  5.389   1    48.17  ? 122 ARG A CZ  1 
ATOM   1010 N  NH1 . ARG A 1 126 ? -19.713 -14.305 6.125   1    44.15  ? 122 ARG A NH1 1 
ATOM   1011 N  NH2 . ARG A 1 126 ? -20.398 -12.142 5.952   1    43.84  ? 122 ARG A NH2 1 
ATOM   1012 N  N   . VAL A 1 127 ? -16.469 -18.107 4.429   1    37.7   ? 123 VAL A N   1 
ATOM   1013 C  CA  . VAL A 1 127 ? -15.222 -17.972 5.18    1    35.92  ? 123 VAL A CA  1 
ATOM   1014 C  C   . VAL A 1 127 ? -14.213 -19.089 4.84    1    39.51  ? 123 VAL A C   1 
ATOM   1015 O  O   . VAL A 1 127 ? -14.486 -20.278 4.999   1    42.56  ? 123 VAL A O   1 
ATOM   1016 C  CB  . VAL A 1 127 ? -15.562 -17.936 6.684   1    35.19  ? 123 VAL A CB  1 
ATOM   1017 C  CG1 . VAL A 1 127 ? -14.325 -18.019 7.61    1    30.18  ? 123 VAL A CG1 1 
ATOM   1018 C  CG2 . VAL A 1 127 ? -16.43  -16.71  6.987   1    34.32  ? 123 VAL A CG2 1 
ATOM   1019 N  N   . LEU A 1 128 ? -13.012 -18.705 4.392   1    36.55  ? 124 LEU A N   1 
ATOM   1020 C  CA  . LEU A 1 128 ? -11.845 -19.573 4.366   1    35.19  ? 124 LEU A CA  1 
ATOM   1021 C  C   . LEU A 1 128 ? -11.128 -19.487 5.727   1    39.03  ? 124 LEU A C   1 
ATOM   1022 O  O   . LEU A 1 128 ? -10.89  -18.382 6.258   1    39.69  ? 124 LEU A O   1 
ATOM   1023 C  CB  . LEU A 1 128 ? -10.88  -19.134 3.256   1    32.55  ? 124 LEU A CB  1 
ATOM   1024 C  CG  . LEU A 1 128 ? -11.363 -19.252 1.811   1    34.79  ? 124 LEU A CG  1 
ATOM   1025 C  CD1 . LEU A 1 128 ? -10.328 -18.793 0.822   1    34.59  ? 124 LEU A CD1 1 
ATOM   1026 C  CD2 . LEU A 1 128 ? -11.743 -20.662 1.479   1    33.53  ? 124 LEU A CD2 1 
ATOM   1027 N  N   . HIS A 1 129 ? -10.712 -20.649 6.246   1    32.5   ? 125 HIS A N   1 
ATOM   1028 C  CA  . HIS A 1 129 ? -9.954  -20.679 7.48    1    36.18  ? 125 HIS A CA  1 
ATOM   1029 C  C   . HIS A 1 129 ? -8.486  -20.31  7.249   1    36.34  ? 125 HIS A C   1 
ATOM   1030 O  O   . HIS A 1 129 ? -7.983  -19.389 7.881   1    33.45  ? 125 HIS A O   1 
ATOM   1031 C  CB  . HIS A 1 129 ? -10.092 -22.03  8.178   1    36.45  ? 125 HIS A CB  1 
ATOM   1032 C  CG  . HIS A 1 129 ? -9.484  -22.005 9.53    1    40.74  ? 125 HIS A CG  1 
ATOM   1033 N  ND1 . HIS A 1 129 ? -8.115  -21.965 9.699   1    41.96  ? 125 HIS A ND1 1 
ATOM   1034 C  CD2 . HIS A 1 129 ? -10.017 -21.964 10.761  1    42.89  ? 125 HIS A CD2 1 
ATOM   1035 C  CE1 . HIS A 1 129 ? -7.837  -21.928 11.003  1    45.75  ? 125 HIS A CE1 1 
ATOM   1036 N  NE2 . HIS A 1 129 ? -8.981  -21.926 11.681  1    42.02  ? 125 HIS A NE2 1 
ATOM   1037 N  N   . ARG A 1 130 ? -7.788  -21.093 6.411   1    38.21  ? 126 ARG A N   1 
ATOM   1038 C  CA  . ARG A 1 130 ? -6.47   -20.722 5.902   1    39.36  ? 126 ARG A CA  1 
ATOM   1039 C  C   . ARG A 1 130 ? -5.351  -20.959 6.921   1    39.49  ? 126 ARG A C   1 
ATOM   1040 O  O   . ARG A 1 130 ? -4.264  -20.411 6.754   1    47.7   ? 126 ARG A O   1 
ATOM   1041 C  CB  . ARG A 1 130 ? -6.402  -19.261 5.429   1    32.99  ? 126 ARG A CB  1 
ATOM   1042 C  CG  . ARG A 1 130 ? -7.313  -18.962 4.25    1    34.27  ? 126 ARG A CG  1 
ATOM   1043 C  CD  . ARG A 1 130 ? -6.941  -17.715 3.476   1    36.5   ? 126 ARG A CD  1 
ATOM   1044 N  NE  . ARG A 1 130 ? -7.005  -16.552 4.366   1    36.55  ? 126 ARG A NE  1 
ATOM   1045 C  CZ  . ARG A 1 130 ? -6.531  -15.351 4.08    1    37.99  ? 126 ARG A CZ  1 
ATOM   1046 N  NH1 . ARG A 1 130 ? -6.118  -15.071 2.864   1    36.12  ? 126 ARG A NH1 1 
ATOM   1047 N  NH2 . ARG A 1 130 ? -6.494  -14.416 5.016   1    38.08  ? 126 ARG A NH2 1 
ATOM   1048 N  N   . ASP A 1 131 ? -5.587  -21.793 7.94    1    35.42  ? 127 ASP A N   1 
ATOM   1049 C  CA  . ASP A 1 131 ? -4.541  -22.217 8.864   1    36.27  ? 127 ASP A CA  1 
ATOM   1050 C  C   . ASP A 1 131 ? -5.009  -23.461 9.621   1    37.59  ? 127 ASP A C   1 
ATOM   1051 O  O   . ASP A 1 131 ? -4.866  -23.555 10.845  1    35.68  ? 127 ASP A O   1 
ATOM   1052 C  CB  . ASP A 1 131 ? -4.16   -21.147 9.887   1    36.44  ? 127 ASP A CB  1 
ATOM   1053 C  CG  . ASP A 1 131 ? -2.719  -21.2   10.392  1    41.84  ? 127 ASP A CG  1 
ATOM   1054 O  OD1 . ASP A 1 131 ? -1.863  -21.842 9.768   1    49.61  ? 127 ASP A OD1 1 
ATOM   1055 O  OD2 . ASP A 1 131 ? -2.444  -20.594 11.414  1    53.89  ? 127 ASP A OD2 1 
ATOM   1056 N  N   . LEU A 1 132 ? -5.617  -24.405 8.894   1    34.2   ? 128 LEU A N   1 
ATOM   1057 C  CA  . LEU A 1 132 ? -6.022  -25.627 9.554   1    37.39  ? 128 LEU A CA  1 
ATOM   1058 C  C   . LEU A 1 132 ? -4.778  -26.473 9.811   1    39.56  ? 128 LEU A C   1 
ATOM   1059 O  O   . LEU A 1 132 ? -4.018  -26.806 8.899   1    41.77  ? 128 LEU A O   1 
ATOM   1060 C  CB  . LEU A 1 132 ? -7.035  -26.294 8.629   1    39.89  ? 128 LEU A CB  1 
ATOM   1061 C  CG  . LEU A 1 132 ? -8.408  -25.611 8.589   1    44.68  ? 128 LEU A CG  1 
ATOM   1062 C  CD1 . LEU A 1 132 ? -9.297  -26.328 7.585   1    40.42  ? 128 LEU A CD1 1 
ATOM   1063 C  CD2 . LEU A 1 132 ? -9.059  -25.546 9.993   1    33.77  ? 128 LEU A CD2 1 
ATOM   1064 N  N   . LYS A 1 133 ? -4.522  -26.721 11.084  1    33.7   ? 129 LYS A N   1 
ATOM   1065 C  CA  . LYS A 1 133 ? -3.423  -27.564 11.513  1    34.98  ? 129 LYS A CA  1 
ATOM   1066 C  C   . LYS A 1 133 ? -3.792  -28.084 12.904  1    39.99  ? 129 LYS A C   1 
ATOM   1067 O  O   . LYS A 1 133 ? -4.701  -27.563 13.543  1    40.98  ? 129 LYS A O   1 
ATOM   1068 C  CB  . LYS A 1 133 ? -2.129  -26.75  11.542  1    32.36  ? 129 LYS A CB  1 
ATOM   1069 C  CG  . LYS A 1 133 ? -2.193  -25.48  12.4    1    36.72  ? 129 LYS A CG  1 
ATOM   1070 C  CD  . LYS A 1 133 ? -0.823  -24.823 12.581  1    40.26  ? 129 LYS A CD  1 
ATOM   1071 C  CE  . LYS A 1 133 ? -0.88   -23.46  13.229  1    44.9   ? 129 LYS A CE  1 
ATOM   1072 N  NZ  . LYS A 1 133 ? 0.376   -22.699 13.083  1    41.24  ? 129 LYS A NZ  1 
ATOM   1073 N  N   . PRO A 1 134 ? -3.137  -29.132 13.432  1    41.07  ? 130 PRO A N   1 
ATOM   1074 C  CA  . PRO A 1 134 ? -3.582  -29.741 14.692  1    42.5   ? 130 PRO A CA  1 
ATOM   1075 C  C   . PRO A 1 134 ? -3.573  -28.846 15.931  1    46.09  ? 130 PRO A C   1 
ATOM   1076 O  O   . PRO A 1 134 ? -4.389  -29.061 16.827  1    57.29  ? 130 PRO A O   1 
ATOM   1077 C  CB  . PRO A 1 134 ? -2.683  -30.965 14.828  1    37.39  ? 130 PRO A CB  1 
ATOM   1078 C  CG  . PRO A 1 134 ? -2.256  -31.234 13.416  1    39.36  ? 130 PRO A CG  1 
ATOM   1079 C  CD  . PRO A 1 134 ? -2.027  -29.849 12.801  1    40.24  ? 130 PRO A CD  1 
ATOM   1080 N  N   . GLN A 1 135 ? -2.651  -27.875 15.986  1    44.19  ? 131 GLN A N   1 
ATOM   1081 C  CA  . GLN A 1 135 ? -2.531  -26.904 17.072  1    45.3   ? 131 GLN A CA  1 
ATOM   1082 C  C   . GLN A 1 135 ? -3.788  -26.02  17.165  1    48.5   ? 131 GLN A C   1 
ATOM   1083 O  O   . GLN A 1 135 ? -4.065  -25.411 18.206  1    52.83  ? 131 GLN A O   1 
ATOM   1084 C  CB  . GLN A 1 135 ? -1.317  -25.993 16.851  1    48.56  ? 131 GLN A CB  1 
ATOM   1085 C  CG  . GLN A 1 135 ? 0.074   -26.638 16.931  1    59.4   ? 131 GLN A CG  1 
ATOM   1086 C  CD  . GLN A 1 135 ? 0.541   -27.451 15.723  1    68.76  ? 131 GLN A CD  1 
ATOM   1087 O  OE1 . GLN A 1 135 ? -0.131  -27.62  14.695  1    63.35  ? 131 GLN A OE1 1 
ATOM   1088 N  NE2 . GLN A 1 135 ? 1.733   -28.012 15.837  1    75.43  ? 131 GLN A NE2 1 
ATOM   1089 N  N   . ASN A 1 136 ? -4.529  -25.895 16.049  1    43.25  ? 132 ASN A N   1 
ATOM   1090 C  CA  . ASN A 1 136 ? -5.658  -24.98  15.924  1    39.21  ? 132 ASN A CA  1 
ATOM   1091 C  C   . ASN A 1 136 ? -6.987  -25.751 15.929  1    35.89  ? 132 ASN A C   1 
ATOM   1092 O  O   . ASN A 1 136 ? -8.011  -25.201 15.582  1    33.82  ? 132 ASN A O   1 
ATOM   1093 C  CB  . ASN A 1 136 ? -5.574  -24.14  14.65   1    37.68  ? 132 ASN A CB  1 
ATOM   1094 C  CG  . ASN A 1 136 ? -4.535  -23.038 14.685  1    41.16  ? 132 ASN A CG  1 
ATOM   1095 O  OD1 . ASN A 1 136 ? -4.07   -22.624 15.761  1    42.42  ? 132 ASN A OD1 1 
ATOM   1096 N  ND2 . ASN A 1 136 ? -4.153  -22.549 13.511  1    33.82  ? 132 ASN A ND2 1 
ATOM   1097 N  N   . LEU A 1 137 ? -6.962  -27.03  16.317  1    35.93  ? 133 LEU A N   1 
ATOM   1098 C  CA  . LEU A 1 137 ? -8.157  -27.821 16.534  1    37.44  ? 133 LEU A CA  1 
ATOM   1099 C  C   . LEU A 1 137 ? -8.254  -28.205 18.015  1    39.48  ? 133 LEU A C   1 
ATOM   1100 O  O   . LEU A 1 137 ? -7.436  -28.97  18.53   1    40.22  ? 133 LEU A O   1 
ATOM   1101 C  CB  . LEU A 1 137 ? -8.101  -29.052 15.638  1    34.92  ? 133 LEU A CB  1 
ATOM   1102 C  CG  . LEU A 1 137 ? -7.677  -28.79  14.192  1    36.13  ? 133 LEU A CG  1 
ATOM   1103 C  CD1 . LEU A 1 137 ? -7.722  -30.08  13.366  1    39.73  ? 133 LEU A CD1 1 
ATOM   1104 C  CD2 . LEU A 1 137 ? -8.537  -27.716 13.585  1    32.16  ? 133 LEU A CD2 1 
ATOM   1105 N  N   . LEU A 1 138 ? -9.272  -27.67  18.698  1    33.79  ? 134 LEU A N   1 
ATOM   1106 C  CA  . LEU A 1 138 ? -9.456  -27.904 20.117  1    38.19  ? 134 LEU A CA  1 
ATOM   1107 C  C   . LEU A 1 138 ? -10.402 -29.08  20.376  1    40.8   ? 134 LEU A C   1 
ATOM   1108 O  O   . LEU A 1 138 ? -11.391 -29.241 19.677  1    43.67  ? 134 LEU A O   1 
ATOM   1109 C  CB  . LEU A 1 138 ? -9.975  -26.566 20.636  1    38.52  ? 134 LEU A CB  1 
ATOM   1110 C  CG  . LEU A 1 138 ? -9.002  -25.389 20.429  1    42.89  ? 134 LEU A CG  1 
ATOM   1111 C  CD1 . LEU A 1 138 ? -9.475  -24.123 21.048  1    38.78  ? 134 LEU A CD1 1 
ATOM   1112 C  CD2 . LEU A 1 138 ? -7.617  -25.663 21.008  1    44.23  ? 134 LEU A CD2 1 
ATOM   1113 N  N   . ILE A 1 139 ? -10.086 -29.907 21.375  1    41.41  ? 135 ILE A N   1 
ATOM   1114 C  CA  . ILE A 1 139 ? -10.916 -31.013 21.822  1    40.7   ? 135 ILE A CA  1 
ATOM   1115 C  C   . ILE A 1 139 ? -11.373 -30.76  23.257  1    45.53  ? 135 ILE A C   1 
ATOM   1116 O  O   . ILE A 1 139 ? -10.652 -30.188 24.079  1    48.65  ? 135 ILE A O   1 
ATOM   1117 C  CB  . ILE A 1 139 ? -10.165 -32.357 21.724  1    41.37  ? 135 ILE A CB  1 
ATOM   1118 C  CG1 . ILE A 1 139 ? -8.929  -32.416 22.606  1    47.66  ? 135 ILE A CG1 1 
ATOM   1119 C  CG2 . ILE A 1 139 ? -9.811  -32.706 20.28   1    41.35  ? 135 ILE A CG2 1 
ATOM   1120 C  CD1 . ILE A 1 139 ? -8.113  -33.686 22.423  1    53.79  ? 135 ILE A CD1 1 
ATOM   1121 N  N   . ASN A 1 140 ? -12.568 -31.248 23.585  1    46.86  ? 136 ASN A N   1 
ATOM   1122 C  CA  . ASN A 1 140 ? -13.05  -31.152 24.957  1    48.13  ? 136 ASN A CA  1 
ATOM   1123 C  C   . ASN A 1 140 ? -13.07  -32.543 25.598  1    49.46  ? 136 ASN A C   1 
ATOM   1124 O  O   . ASN A 1 140 ? -12.568 -33.503 25.008  1    48.71  ? 136 ASN A O   1 
ATOM   1125 C  CB  . ASN A 1 140 ? -14.37  -30.378 25.004  1    49.33  ? 136 ASN A CB  1 
ATOM   1126 C  CG  . ASN A 1 140 ? -15.534 -31.113 24.385  1    48.95  ? 136 ASN A CG  1 
ATOM   1127 O  OD1 . ASN A 1 140 ? -15.505 -32.341 24.197  1    48.77  ? 136 ASN A OD1 1 
ATOM   1128 N  ND2 . ASN A 1 140 ? -16.59  -30.37  24.11   1    48.35  ? 136 ASN A ND2 1 
ATOM   1129 N  N   . THR A 1 141 ? -13.678 -32.643 26.788  1    52.26  ? 137 THR A N   1 
ATOM   1130 C  CA  . THR A 1 141 ? -13.755 -33.893 27.536  1    53.26  ? 137 THR A CA  1 
ATOM   1131 C  C   . THR A 1 141 ? -14.883 -34.786 26.991  1    56.57  ? 137 THR A C   1 
ATOM   1132 O  O   . THR A 1 141 ? -14.857 -35.997 27.191  1    57.03  ? 137 THR A O   1 
ATOM   1133 C  CB  . THR A 1 141 ? -13.914 -33.558 29.024  1    53.72  ? 137 THR A CB  1 
ATOM   1134 O  OG1 . THR A 1 141 ? -14.864 -32.514 29.223  1    57.2   ? 137 THR A OG1 1 
ATOM   1135 C  CG2 . THR A 1 141 ? -12.652 -32.991 29.629  1    55.03  ? 137 THR A CG2 1 
ATOM   1136 N  N   . GLU A 1 142 ? -15.835 -34.188 26.254  1    60.18  ? 138 GLU A N   1 
ATOM   1137 C  CA  . GLU A 1 142 ? -17.034 -34.861 25.777  1    62.39  ? 138 GLU A CA  1 
ATOM   1138 C  C   . GLU A 1 142 ? -16.802 -35.522 24.412  1    63.28  ? 138 GLU A C   1 
ATOM   1139 O  O   . GLU A 1 142 ? -17.669 -36.263 23.945  1    62.91  ? 138 GLU A O   1 
ATOM   1140 C  CB  . GLU A 1 142 ? -18.207 -33.876 25.749  1    63.37  ? 138 GLU A CB  1 
ATOM   1141 C  CG  . GLU A 1 142 ? -18.632 -33.416 27.141  1    66.96  ? 138 GLU A CG  1 
ATOM   1142 C  CD  . GLU A 1 142 ? -19.52  -34.421 27.859  1    74.29  ? 138 GLU A CD  1 
ATOM   1143 O  OE1 . GLU A 1 142 ? -20.178 -35.252 27.201  1    71.49  ? 138 GLU A OE1 1 
ATOM   1144 O  OE2 . GLU A 1 142 ? -19.548 -34.393 29.099  1    81.71  ? 138 GLU A OE2 1 
ATOM   1145 N  N   . GLY A 1 143 ? -15.652 -35.24  23.772  1    54.67  ? 139 GLY A N   1 
ATOM   1146 C  CA  . GLY A 1 143 ? -15.278 -35.891 22.525  1    47.52  ? 139 GLY A CA  1 
ATOM   1147 C  C   . GLY A 1 143 ? -15.537 -35.015 21.309  1    44.7   ? 139 GLY A C   1 
ATOM   1148 O  O   . GLY A 1 143 ? -15.522 -35.495 20.176  1    42.59  ? 139 GLY A O   1 
ATOM   1149 N  N   . ALA A 1 144 ? -15.799 -33.727 21.555  1    42.18  ? 140 ALA A N   1 
ATOM   1150 C  CA  . ALA A 1 144 ? -15.963 -32.769 20.468  1    40.49  ? 140 ALA A CA  1 
ATOM   1151 C  C   . ALA A 1 144 ? -14.593 -32.249 20.005  1    41.94  ? 140 ALA A C   1 
ATOM   1152 O  O   . ALA A 1 144 ? -13.651 -32.186 20.792  1    46.33  ? 140 ALA A O   1 
ATOM   1153 C  CB  . ALA A 1 144 ? -16.798 -31.633 20.993  1    39.55  ? 140 ALA A CB  1 
ATOM   1154 N  N   . ILE A 1 145 ? -14.493 -31.866 18.725  1    39.26  ? 141 ILE A N   1 
ATOM   1155 C  CA  . ILE A 1 145 ? -13.324 -31.183 18.196  1    38.88  ? 141 ILE A CA  1 
ATOM   1156 C  C   . ILE A 1 145 ? -13.823 -29.978 17.392  1    40.04  ? 141 ILE A C   1 
ATOM   1157 O  O   . ILE A 1 145 ? -14.882 -30.045 16.755  1    38.36  ? 141 ILE A O   1 
ATOM   1158 C  CB  . ILE A 1 145 ? -12.445 -32.13  17.366  1    38.82  ? 141 ILE A CB  1 
ATOM   1159 C  CG1 . ILE A 1 145 ? -11.084 -31.5   17.018  1    39.87  ? 141 ILE A CG1 1 
ATOM   1160 C  CG2 . ILE A 1 145 ? -13.212 -32.598 16.119  1    39.28  ? 141 ILE A CG2 1 
ATOM   1161 C  CD1 . ILE A 1 145 ? -10.091 -32.426 16.345  1    34.36  ? 141 ILE A CD1 1 
ATOM   1162 N  N   . LYS A 1 146 ? -13.117 -28.836 17.51   1    39.27  ? 142 LYS A N   1 
ATOM   1163 C  CA  . LYS A 1 146 ? -13.658 -27.578 17.013  1    37.85  ? 142 LYS A CA  1 
ATOM   1164 C  C   . LYS A 1 146 ? -12.559 -26.769 16.339  1    40.92  ? 142 LYS A C   1 
ATOM   1165 O  O   . LYS A 1 146 ? -11.468 -26.677 16.892  1    43.8   ? 142 LYS A O   1 
ATOM   1166 C  CB  . LYS A 1 146 ? -14.234 -26.747 18.157  1    35.6   ? 142 LYS A CB  1 
ATOM   1167 C  CG  . LYS A 1 146 ? -15.234 -27.499 18.997  1    38.61  ? 142 LYS A CG  1 
ATOM   1168 C  CD  . LYS A 1 146 ? -16.238 -26.637 19.771  1    37.4   ? 142 LYS A CD  1 
ATOM   1169 C  CE  . LYS A 1 146 ? -17.048 -27.566 20.667  1    35.89  ? 142 LYS A CE  1 
ATOM   1170 N  NZ  . LYS A 1 146 ? -18.317 -26.957 21.046  1    37.69  ? 142 LYS A NZ  1 
ATOM   1171 N  N   . LEU A 1 147 ? -12.857 -26.201 15.153  1    40.71  ? 143 LEU A N   1 
ATOM   1172 C  CA  . LEU A 1 147 ? -11.931 -25.299 14.487  1    36.5   ? 143 LEU A CA  1 
ATOM   1173 C  C   . LEU A 1 147 ? -11.73  -24.106 15.419  1    42.07  ? 143 LEU A C   1 
ATOM   1174 O  O   . LEU A 1 147 ? -12.709 -23.548 15.931  1    40.65  ? 143 LEU A O   1 
ATOM   1175 C  CB  . LEU A 1 147 ? -12.399 -24.808 13.116  1    31.9   ? 143 LEU A CB  1 
ATOM   1176 C  CG  . LEU A 1 147 ? -13.082 -25.81  12.183  1    34.57  ? 143 LEU A CG  1 
ATOM   1177 C  CD1 . LEU A 1 147 ? -13.186 -25.167 10.796  1    37.2   ? 143 LEU A CD1 1 
ATOM   1178 C  CD2 . LEU A 1 147 ? -12.378 -27.134 12.092  1    30.84  ? 143 LEU A CD2 1 
ATOM   1179 N  N   . ALA A 1 148 ? -10.468 -23.68  15.558  1    38.75  ? 144 ALA A N   1 
ATOM   1180 C  CA  . ALA A 1 148 ? -10.146 -22.488 16.323  1    41.75  ? 144 ALA A CA  1 
ATOM   1181 C  C   . ALA A 1 148 ? -9.108  -21.663 15.571  1    42.76  ? 144 ALA A C   1 
ATOM   1182 O  O   . ALA A 1 148 ? -8.586  -22.109 14.54   1    47.24  ? 144 ALA A O   1 
ATOM   1183 C  CB  . ALA A 1 148 ? -9.703  -22.855 17.739  1    42.3   ? 144 ALA A CB  1 
ATOM   1184 N  N   . ASP A 1 149 ? -8.858  -20.461 16.1    1    40.16  ? 145 ASP A N   1 
ATOM   1185 C  CA  . ASP A 1 149 ? -7.921  -19.46  15.618  1    43.99  ? 145 ASP A CA  1 
ATOM   1186 C  C   . ASP A 1 149 ? -8.263  -18.999 14.203  1    40.61  ? 145 ASP A C   1 
ATOM   1187 O  O   . ASP A 1 149 ? -7.668  -19.478 13.244  1    37.03  ? 145 ASP A O   1 
ATOM   1188 C  CB  . ASP A 1 149 ? -6.456  -19.844 15.793  1    48.99  ? 145 ASP A CB  1 
ATOM   1189 C  CG  . ASP A 1 149 ? -5.498  -18.65  15.706  1    64.62  ? 145 ASP A CG  1 
ATOM   1190 O  OD1 . ASP A 1 149 ? -5.975  -17.501 15.433  1    70.69  ? 145 ASP A OD1 1 
ATOM   1191 O  OD2 . ASP A 1 149 ? -4.283  -18.845 15.94   1    89.39  ? 145 ASP A OD2 1 
ATOM   1192 N  N   . PHE A 1 150 ? -9.153  -18.008 14.11   1    41.07  ? 146 PHE A N   1 
ATOM   1193 C  CA  . PHE A 1 150 ? -9.621  -17.466 12.844  1    43.32  ? 146 PHE A CA  1 
ATOM   1194 C  C   . PHE A 1 150 ? -8.92   -16.142 12.521  1    47.84  ? 146 PHE A C   1 
ATOM   1195 O  O   . PHE A 1 150 ? -9.439  -15.332 11.736  1    41.26  ? 146 PHE A O   1 
ATOM   1196 C  CB  . PHE A 1 150 ? -11.142 -17.293 12.906  1    42.7   ? 146 PHE A CB  1 
ATOM   1197 C  CG  . PHE A 1 150 ? -11.942 -18.56  12.658  1    36.64  ? 146 PHE A CG  1 
ATOM   1198 C  CD1 . PHE A 1 150 ? -12.068 -19.515 13.656  1    32.64  ? 146 PHE A CD1 1 
ATOM   1199 C  CD2 . PHE A 1 150 ? -12.623 -18.748 11.461  1    32     ? 146 PHE A CD2 1 
ATOM   1200 C  CE1 . PHE A 1 150 ? -12.775 -20.682 13.435  1    31.13  ? 146 PHE A CE1 1 
ATOM   1201 C  CE2 . PHE A 1 150 ? -13.356 -19.909 11.259  1    33.24  ? 146 PHE A CE2 1 
ATOM   1202 C  CZ  . PHE A 1 150 ? -13.427 -20.875 12.241  1    30.84  ? 146 PHE A CZ  1 
ATOM   1203 N  N   . GLY A 1 151 ? -7.718  -15.961 13.094  1    46.64  ? 147 GLY A N   1 
ATOM   1204 C  CA  . GLY A 1 151 ? -6.899  -14.769 12.895  1    46.96  ? 147 GLY A CA  1 
ATOM   1205 C  C   . GLY A 1 151 ? -6.422  -14.626 11.445  1    47.96  ? 147 GLY A C   1 
ATOM   1206 O  O   . GLY A 1 151 ? -6.3    -13.514 10.933  1    51.45  ? 147 GLY A O   1 
ATOM   1207 N  N   . LEU A 1 152 ? -6.218  -15.761 10.776  1    47.37  ? 148 LEU A N   1 
ATOM   1208 C  CA  . LEU A 1 152 ? -5.843  -15.769 9.371   1    52.78  ? 148 LEU A CA  1 
ATOM   1209 C  C   . LEU A 1 152 ? -7.017  -16.048 8.434   1    45.73  ? 148 LEU A C   1 
ATOM   1210 O  O   . LEU A 1 152 ? -6.775  -16.191 7.248   1    47.9   ? 148 LEU A O   1 
ATOM   1211 C  CB  . LEU A 1 152 ? -4.738  -16.774 9.096   1    52.75  ? 148 LEU A CB  1 
ATOM   1212 C  CG  . LEU A 1 152 ? -3.468  -16.454 9.864   1    64.92  ? 148 LEU A CG  1 
ATOM   1213 C  CD1 . LEU A 1 152 ? -3.205  -17.567 10.884  1    78.19  ? 148 LEU A CD1 1 
ATOM   1214 C  CD2 . LEU A 1 152 ? -2.38   -16.198 8.865   1    63.74  ? 148 LEU A CD2 1 
ATOM   1215 N  N   . ALA A 1 153 ? -8.245  -16.103 8.953   1    39.66  ? 149 ALA A N   1 
ATOM   1216 C  CA  . ALA A 1 153 ? -9.404  -16.417 8.138   1    41.66  ? 149 ALA A CA  1 
ATOM   1217 C  C   . ALA A 1 153 ? -9.74   -15.234 7.224   1    44.62  ? 149 ALA A C   1 
ATOM   1218 O  O   . ALA A 1 153 ? -9.159  -14.145 7.355   1    43.4   ? 149 ALA A O   1 
ATOM   1219 C  CB  . ALA A 1 153 ? -10.544 -16.759 9.06    1    39.57  ? 149 ALA A CB  1 
ATOM   1220 N  N   . ARG A 1 154 ? -10.695 -15.442 6.308   1    38.94  ? 150 ARG A N   1 
ATOM   1221 C  CA  . ARG A 1 154 ? -11.039 -14.364 5.398   1    43.28  ? 150 ARG A CA  1 
ATOM   1222 C  C   . ARG A 1 154 ? -12.392 -14.604 4.734   1    43.12  ? 150 ARG A C   1 
ATOM   1223 O  O   . ARG A 1 154 ? -12.667 -15.704 4.236   1    43.16  ? 150 ARG A O   1 
ATOM   1224 C  CB  . ARG A 1 154 ? -9.835  -14.17  4.463   1    45.61  ? 150 ARG A CB  1 
ATOM   1225 C  CG  . ARG A 1 154 ? -10.097 -13.838 3.006   1    42.71  ? 150 ARG A CG  1 
ATOM   1226 C  CD  . ARG A 1 154 ? -10.166 -12.384 2.793   1    47.16  ? 150 ARG A CD  1 
ATOM   1227 N  NE  . ARG A 1 154 ? -8.942  -11.822 2.216   1    46.39  ? 150 ARG A NE  1 
ATOM   1228 C  CZ  . ARG A 1 154 ? -8.903  -10.612 1.649   1    44.21  ? 150 ARG A CZ  1 
ATOM   1229 N  NH1 . ARG A 1 154 ? -7.765  -10.06  1.329   1    40.71  ? 150 ARG A NH1 1 
ATOM   1230 N  NH2 . ARG A 1 154 ? -10.014 -9.91   1.496   1    46.94  ? 150 ARG A NH2 1 
ATOM   1231 N  N   . ALA A 1 155 ? -13.198 -13.534 4.712   1    38.5   ? 151 ALA A N   1 
ATOM   1232 C  CA  . ALA A 1 155 ? -14.451 -13.506 3.979   1    35.92  ? 151 ALA A CA  1 
ATOM   1233 C  C   . ALA A 1 155 ? -14.191 -13.438 2.471   1    38.39  ? 151 ALA A C   1 
ATOM   1234 O  O   . ALA A 1 155 ? -13.614 -12.478 1.975   1    42.95  ? 151 ALA A O   1 
ATOM   1235 C  CB  . ALA A 1 155 ? -15.243 -12.322 4.447   1    34.84  ? 151 ALA A CB  1 
ATOM   1236 N  N   . PHE A 1 156 ? -14.66  -14.442 1.732   1    36.38  ? 152 PHE A N   1 
ATOM   1237 C  CA  . PHE A 1 156 ? -14.447 -14.481 0.299   1    38.17  ? 152 PHE A CA  1 
ATOM   1238 C  C   . PHE A 1 156 ? -15.707 -14.078 -0.447  1    42.78  ? 152 PHE A C   1 
ATOM   1239 O  O   . PHE A 1 156 ? -16.811 -14.077 0.119   1    43.79  ? 152 PHE A O   1 
ATOM   1240 C  CB  . PHE A 1 156 ? -13.926 -15.811 -0.247  1    37.07  ? 152 PHE A CB  1 
ATOM   1241 C  CG  . PHE A 1 156 ? -14.744 -17.077 -0.028  1    37.59  ? 152 PHE A CG  1 
ATOM   1242 C  CD1 . PHE A 1 156 ? -14.668 -17.777 1.182   1    34.26  ? 152 PHE A CD1 1 
ATOM   1243 C  CD2 . PHE A 1 156 ? -15.521 -17.606 -1.064  1    37.82  ? 152 PHE A CD2 1 
ATOM   1244 C  CE1 . PHE A 1 156 ? -15.406 -18.942 1.367   1    34.88  ? 152 PHE A CE1 1 
ATOM   1245 C  CE2 . PHE A 1 156 ? -16.198 -18.811 -0.909  1    37.1   ? 152 PHE A CE2 1 
ATOM   1246 C  CZ  . PHE A 1 156 ? -16.16  -19.461 0.317   1    37.92  ? 152 PHE A CZ  1 
ATOM   1247 N  N   . GLY A 1 157 ? -15.48  -13.632 -1.701  1    42.31  ? 153 GLY A N   1 
ATOM   1248 C  CA  . GLY A 1 157 ? -16.508 -13.367 -2.697  1    35.71  ? 153 GLY A CA  1 
ATOM   1249 C  C   . GLY A 1 157 ? -16.603 -14.545 -3.656  1    35.18  ? 153 GLY A C   1 
ATOM   1250 O  O   . GLY A 1 157 ? -15.711 -15.393 -3.68   1    35.95  ? 153 GLY A O   1 
ATOM   1251 N  N   . VAL A 1 158 ? -17.683 -14.585 -4.437  1    36.58  ? 154 VAL A N   1 
ATOM   1252 C  CA  . VAL A 1 158 ? -17.916 -15.651 -5.402  1    39.48  ? 154 VAL A CA  1 
ATOM   1253 C  C   . VAL A 1 158 ? -18.075 -15.046 -6.802  1    39.21  ? 154 VAL A C   1 
ATOM   1254 O  O   . VAL A 1 158 ? -18.97  -14.231 -6.999  1    38.48  ? 154 VAL A O   1 
ATOM   1255 C  CB  . VAL A 1 158 ? -19.158 -16.471 -5.011  1    42.97  ? 154 VAL A CB  1 
ATOM   1256 C  CG1 . VAL A 1 158 ? -19.443 -17.535 -6.069  1    45.95  ? 154 VAL A CG1 1 
ATOM   1257 C  CG2 . VAL A 1 158 ? -19.015 -17.107 -3.619  1    40.97  ? 154 VAL A CG2 1 
ATOM   1258 N  N   . PRO A 1 159 ? -17.182 -15.329 -7.789  1    39.47  ? 155 PRO A N   1 
ATOM   1259 C  CA  . PRO A 1 159 ? -15.959 -16.105 -7.581  1    38.6   ? 155 PRO A CA  1 
ATOM   1260 C  C   . PRO A 1 159 ? -14.937 -15.345 -6.746  1    42.91  ? 155 PRO A C   1 
ATOM   1261 O  O   . PRO A 1 159 ? -15.065 -14.132 -6.576  1    42.64  ? 155 PRO A O   1 
ATOM   1262 C  CB  . PRO A 1 159 ? -15.438 -16.337 -9.014  1    37.53  ? 155 PRO A CB  1 
ATOM   1263 C  CG  . PRO A 1 159 ? -15.918 -15.188 -9.804  1    38.03  ? 155 PRO A CG  1 
ATOM   1264 C  CD  . PRO A 1 159 ? -17.285 -14.854 -9.184  1    41.93  ? 155 PRO A CD  1 
ATOM   1265 N  N   . VAL A 1 160 ? -13.926 -16.073 -6.23   1    44.6   ? 156 VAL A N   1 
ATOM   1266 C  CA  . VAL A 1 160 ? -12.883 -15.484 -5.394  1    42.05  ? 156 VAL A CA  1 
ATOM   1267 C  C   . VAL A 1 160 ? -12.012 -14.508 -6.197  1    44.52  ? 156 VAL A C   1 
ATOM   1268 O  O   . VAL A 1 160 ? -11.844 -14.622 -7.412  1    44.94  ? 156 VAL A O   1 
ATOM   1269 C  CB  . VAL A 1 160 ? -12.008 -16.574 -4.771  1    38.91  ? 156 VAL A CB  1 
ATOM   1270 C  CG1 . VAL A 1 160 ? -12.809 -17.436 -3.813  1    38.5   ? 156 VAL A CG1 1 
ATOM   1271 C  CG2 . VAL A 1 160 ? -11.337 -17.419 -5.85   1    36.81  ? 156 VAL A CG2 1 
ATOM   1272 N  N   . ARG A 1 161 ? -11.428 -13.568 -5.462  1    46.99  ? 157 ARG A N   1 
ATOM   1273 C  CA  . ARG A 1 161 ? -10.44  -12.68  -6.112  1    51.93  ? 157 ARG A CA  1 
ATOM   1274 C  C   . ARG A 1 161 ? -9.091  -13.077 -5.496  1    49.63  ? 157 ARG A C   1 
ATOM   1275 O  O   . ARG A 1 161 ? -9.068  -14.012 -4.666  1    46.26  ? 157 ARG A O   1 
ATOM   1276 C  CB  . ARG A 1 161 ? -10.822 -11.208 -5.928  1    56.3   ? 157 ARG A CB  1 
ATOM   1277 C  CG  . ARG A 1 161 ? -10.541 -10.634 -4.549  1    71.86  ? 157 ARG A CG  1 
ATOM   1278 C  CD  . ARG A 1 161 ? -10.469 -9.124  -4.622  1    77.92  ? 157 ARG A CD  1 
ATOM   1279 N  NE  . ARG A 1 161 ? -9.791  -8.557  -3.453  1    83.09  ? 157 ARG A NE  1 
ATOM   1280 C  CZ  . ARG A 1 161 ? -10.417 -8.201  -2.342  1    77.08  ? 157 ARG A CZ  1 
ATOM   1281 N  NH1 . ARG A 1 161 ? -11.623 -7.666  -2.407  1    76.51  ? 157 ARG A NH1 1 
ATOM   1282 N  NH2 . ARG A 1 161 ? -9.834  -8.383  -1.172  1    65.64  ? 157 ARG A NH2 1 
ATOM   1283 N  N   . THR A 1 162 ? -8.014  -12.415 -5.894  1    52.45  ? 158 THR A N   1 
ATOM   1284 C  CA  . THR A 1 162 ? -6.683  -12.743 -5.385  1    53.16  ? 158 THR A CA  1 
ATOM   1285 C  C   . THR A 1 162 ? -6.6    -12.299 -3.926  1    48.78  ? 158 THR A C   1 
ATOM   1286 O  O   . THR A 1 162 ? -6.928  -11.151 -3.624  1    49.97  ? 158 THR A O   1 
ATOM   1287 C  CB  . THR A 1 162 ? -5.594  -12.056 -6.214  1    58.05  ? 158 THR A CB  1 
ATOM   1288 O  OG1 . THR A 1 162 ? -5.607  -12.57  -7.543  1    67.4   ? 158 THR A OG1 1 
ATOM   1289 C  CG2 . THR A 1 162 ? -4.207  -12.268 -5.634  1    48.85  ? 158 THR A CG2 1 
ATOM   1290 N  N   . TYR A 1 163 ? -6.168  -13.209 -3.04   1    43.81  ? 159 TYR A N   1 
ATOM   1291 C  CA  . TYR A 1 163 ? -5.984  -12.887 -1.621  1    46.98  ? 159 TYR A CA  1 
ATOM   1292 C  C   . TYR A 1 163 ? -4.508  -13.021 -1.21   1    42.71  ? 159 TYR A C   1 
ATOM   1293 O  O   . TYR A 1 163 ? -3.638  -13.208 -2.021  1    43.62  ? 159 TYR A O   1 
ATOM   1294 C  CB  . TYR A 1 163 ? -6.88   -13.787 -0.754  1    49.6   ? 159 TYR A CB  1 
ATOM   1295 C  CG  . TYR A 1 163 ? -8.352  -13.761 -1.143  1    52.47  ? 159 TYR A CG  1 
ATOM   1296 C  CD1 . TYR A 1 163 ? -9.022  -12.558 -1.35   1    46.17  ? 159 TYR A CD1 1 
ATOM   1297 C  CD2 . TYR A 1 163 ? -9.047  -14.947 -1.36   1    48.43  ? 159 TYR A CD2 1 
ATOM   1298 C  CE1 . TYR A 1 163 ? -10.352 -12.54  -1.712  1    44.38  ? 159 TYR A CE1 1 
ATOM   1299 C  CE2 . TYR A 1 163 ? -10.374 -14.938 -1.753  1    43.95  ? 159 TYR A CE2 1 
ATOM   1300 C  CZ  . TYR A 1 163 ? -11.017 -13.731 -1.937  1    45.33  ? 159 TYR A CZ  1 
ATOM   1301 O  OH  . TYR A 1 163 ? -12.325 -13.74  -2.319  1    46.81  ? 159 TYR A OH  1 
HETATM 1302 N  N   . TPO A 1 164 ? -4.209  -12.96  0.074   1    43.08  ? 160 TPO A N   1 
HETATM 1303 C  CA  . TPO A 1 164 ? -2.839  -13.028 0.548   1    44.36  ? 160 TPO A CA  1 
HETATM 1304 C  CB  . TPO A 1 164 ? -2.829  -12.779 2.072   1    45.32  ? 160 TPO A CB  1 
HETATM 1305 C  CG2 . TPO A 1 164 ? -1.447  -12.592 2.661   1    38.91  ? 160 TPO A CG2 1 
HETATM 1306 O  OG1 . TPO A 1 164 ? -3.592  -11.524 2.285   1    47.16  ? 160 TPO A OG1 1 
HETATM 1307 P  P   . TPO A 1 164 ? -4.956  -11.49  3.129   1    43.68  ? 160 TPO A P   1 
HETATM 1308 O  O1P . TPO A 1 164 ? -5.977  -12.293 2.368   1    42.27  ? 160 TPO A O1P 1 
HETATM 1309 O  O2P . TPO A 1 164 ? -5.262  -10.01  3.238   1    41.47  ? 160 TPO A O2P 1 
HETATM 1310 O  O3P . TPO A 1 164 ? -4.677  -12.159 4.469   1    41.4   ? 160 TPO A O3P 1 
HETATM 1311 C  C   . TPO A 1 164 ? -2.203  -14.362 0.152   1    45.46  ? 160 TPO A C   1 
HETATM 1312 O  O   . TPO A 1 164 ? -2.844  -15.417 0.209   1    45.27  ? 160 TPO A O   1 
ATOM   1313 N  N   . HIS A 1 165 ? -0.91   -14.298 -0.196  1    48.17  ? 161 HIS A N   1 
ATOM   1314 C  CA  . HIS A 1 165 ? -0.171  -15.457 -0.663  1    56.09  ? 161 HIS A CA  1 
ATOM   1315 C  C   . HIS A 1 165 ? 0.597   -16.124 0.486   1    59.48  ? 161 HIS A C   1 
ATOM   1316 O  O   . HIS A 1 165 ? 0.775   -15.536 1.557   1    61.67  ? 161 HIS A O   1 
ATOM   1317 C  CB  . HIS A 1 165 ? 0.68    -15.041 -1.864  1    58.69  ? 161 HIS A CB  1 
ATOM   1318 C  CG  . HIS A 1 165 ? 1.559   -16.153 -2.344  1    92.73  ? 161 HIS A CG  1 
ATOM   1319 N  ND1 . HIS A 1 165 ? 1.165   -17.476 -2.452  1    87.81  ? 161 HIS A ND1 1 
ATOM   1320 C  CD2 . HIS A 1 165 ? 2.838   -16.111 -2.748  1    104.04 ? 161 HIS A CD2 1 
ATOM   1321 C  CE1 . HIS A 1 165 ? 2.187   -18.204 -2.871  1    88.15  ? 161 HIS A CE1 1 
ATOM   1322 N  NE2 . HIS A 1 165 ? 3.209   -17.393 -3.076  1    104.32 ? 161 HIS A NE2 1 
ATOM   1323 N  N   . GLU A 1 166 ? 1.05    -17.367 0.256   1    65.53  ? 162 GLU A N   1 
ATOM   1324 C  CA  . GLU A 1 166 ? 1.82    -18.157 1.222   1    85.88  ? 162 GLU A CA  1 
ATOM   1325 C  C   . GLU A 1 166 ? 1.097   -18.158 2.577   1    90.29  ? 162 GLU A C   1 
ATOM   1326 O  O   . GLU A 1 166 ? 1.734   -18.116 3.627   1    116.33 ? 162 GLU A O   1 
ATOM   1327 C  CB  . GLU A 1 166 ? 3.271   -17.673 1.38    1    91.47  ? 162 GLU A CB  1 
ATOM   1328 C  CG  . GLU A 1 166 ? 3.924   -17.196 0.084   1    97.59  ? 162 GLU A CG  1 
ATOM   1329 C  CD  . GLU A 1 166 ? 5.071   -16.205 0.228   1    99.47  ? 162 GLU A CD  1 
ATOM   1330 O  OE1 . GLU A 1 166 ? 4.858   -15.128 0.829   1    114.75 ? 162 GLU A OE1 1 
ATOM   1331 O  OE2 . GLU A 1 166 ? 6.179   -16.495 -0.268  1    92.97  ? 162 GLU A OE2 1 
ATOM   1332 N  N   . VAL A 1 167 ? -0.246  -18.136 2.542   1    74.06  ? 163 VAL A N   1 
ATOM   1333 C  CA  . VAL A 1 167 ? -1.084  -18.365 3.711   1    54.73  ? 163 VAL A CA  1 
ATOM   1334 C  C   . VAL A 1 167 ? -0.934  -19.845 4.065   1    44.9   ? 163 VAL A C   1 
ATOM   1335 O  O   . VAL A 1 167 ? -0.37   -20.595 3.269   1    47.55  ? 163 VAL A O   1 
ATOM   1336 C  CB  . VAL A 1 167 ? -2.541  -18.014 3.348   1    50.5   ? 163 VAL A CB  1 
ATOM   1337 C  CG1 . VAL A 1 167 ? -2.751  -16.51  3.383   1    49.67  ? 163 VAL A CG1 1 
ATOM   1338 C  CG2 . VAL A 1 167 ? -2.949  -18.571 1.981   1    47.44  ? 163 VAL A CG2 1 
ATOM   1339 N  N   . VAL A 1 168 ? -1.379  -20.245 5.259   1    37.36  ? 164 VAL A N   1 
ATOM   1340 C  CA  . VAL A 1 168 ? -1.351  -21.63  5.713   1    37.11  ? 164 VAL A CA  1 
ATOM   1341 C  C   . VAL A 1 168 ? 0.058   -22     6.197   1    45.56  ? 164 VAL A C   1 
ATOM   1342 O  O   . VAL A 1 168 ? 1.042   -21.813 5.468   1    44.65  ? 164 VAL A O   1 
ATOM   1343 C  CB  . VAL A 1 168 ? -1.87   -22.624 4.65    1    32.26  ? 164 VAL A CB  1 
ATOM   1344 C  CG1 . VAL A 1 168 ? -2.166  -23.995 5.262   1    31.18  ? 164 VAL A CG1 1 
ATOM   1345 C  CG2 . VAL A 1 168 ? -3.151  -22.116 3.972   1    30.41  ? 164 VAL A CG2 1 
ATOM   1346 N  N   . THR A 1 169 ? 0.16    -22.508 7.439   1    41.5   ? 165 THR A N   1 
ATOM   1347 C  CA  . THR A 1 169 ? 1.417   -23.074 7.91    1    40.65  ? 165 THR A CA  1 
ATOM   1348 C  C   . THR A 1 169 ? 1.876   -24.109 6.875   1    45.62  ? 165 THR A C   1 
ATOM   1349 O  O   . THR A 1 169 ? 1.081   -24.943 6.403   1    44.11  ? 165 THR A O   1 
ATOM   1350 C  CB  . THR A 1 169 ? 1.245   -23.717 9.294   1    39.34  ? 165 THR A CB  1 
ATOM   1351 O  OG1 . THR A 1 169 ? 0.827   -22.688 10.182  1    40.97  ? 165 THR A OG1 1 
ATOM   1352 C  CG2 . THR A 1 169 ? 2.504   -24.412 9.789   1    33.18  ? 165 THR A CG2 1 
ATOM   1353 N  N   . LEU A 1 170 ? 3.189   -24.085 6.598   1    43.42  ? 166 LEU A N   1 
ATOM   1354 C  CA  . LEU A 1 170 ? 3.777   -24.662 5.403   1    42.31  ? 166 LEU A CA  1 
ATOM   1355 C  C   . LEU A 1 170 ? 3.404   -26.139 5.266   1    46.66  ? 166 LEU A C   1 
ATOM   1356 O  O   . LEU A 1 170 ? 3.068   -26.591 4.173   1    45.87  ? 166 LEU A O   1 
ATOM   1357 C  CB  . LEU A 1 170 ? 5.288   -24.455 5.476   1    44.45  ? 166 LEU A CB  1 
ATOM   1358 C  CG  . LEU A 1 170 ? 6.122   -25.026 4.317   1    49.98  ? 166 LEU A CG  1 
ATOM   1359 C  CD1 . LEU A 1 170 ? 5.846   -24.305 2.981   1    47.76  ? 166 LEU A CD1 1 
ATOM   1360 C  CD2 . LEU A 1 170 ? 7.601   -24.964 4.687   1    41.08  ? 166 LEU A CD2 1 
ATOM   1361 N  N   . TRP A 1 171 ? 3.484   -26.911 6.365   1    43.52  ? 167 TRP A N   1 
ATOM   1362 C  CA  . TRP A 1 171 ? 3.296   -28.347 6.196   1    39.61  ? 167 TRP A CA  1 
ATOM   1363 C  C   . TRP A 1 171 ? 1.894   -28.662 5.688   1    38.6   ? 167 TRP A C   1 
ATOM   1364 O  O   . TRP A 1 171 ? 1.674   -29.764 5.199   1    39.31  ? 167 TRP A O   1 
ATOM   1365 C  CB  . TRP A 1 171 ? 3.561   -29.114 7.495   1    37.77  ? 167 TRP A CB  1 
ATOM   1366 C  CG  . TRP A 1 171 ? 4.981   -29.062 7.981   1    38.14  ? 167 TRP A CG  1 
ATOM   1367 C  CD1 . TRP A 1 171 ? 6.088   -28.614 7.311   1    36.01  ? 167 TRP A CD1 1 
ATOM   1368 C  CD2 . TRP A 1 171 ? 5.43    -29.518 9.271   1    36.92  ? 167 TRP A CD2 1 
ATOM   1369 N  NE1 . TRP A 1 171 ? 7.193   -28.72  8.12    1    39.5   ? 167 TRP A NE1 1 
ATOM   1370 C  CE2 . TRP A 1 171 ? 6.83    -29.283 9.32    1    40.6   ? 167 TRP A CE2 1 
ATOM   1371 C  CE3 . TRP A 1 171 ? 4.794   -30.071 10.386  1    37.97  ? 167 TRP A CE3 1 
ATOM   1372 C  CZ2 . TRP A 1 171 ? 7.602   -29.618 10.437  1    41.22  ? 167 TRP A CZ2 1 
ATOM   1373 C  CZ3 . TRP A 1 171 ? 5.558   -30.444 11.479  1    40.53  ? 167 TRP A CZ3 1 
ATOM   1374 C  CH2 . TRP A 1 171 ? 6.955   -30.226 11.498  1    41.06  ? 167 TRP A CH2 1 
ATOM   1375 N  N   . TYR A 1 172 ? 0.953   -27.71  5.841   1    35.76  ? 168 TYR A N   1 
ATOM   1376 C  CA  . TYR A 1 172 ? -0.464  -27.954 5.573   1    36.92  ? 168 TYR A CA  1 
ATOM   1377 C  C   . TYR A 1 172 ? -0.918  -27.184 4.316   1    36.14  ? 168 TYR A C   1 
ATOM   1378 O  O   . TYR A 1 172 ? -2.102  -27.164 3.975   1    35.8   ? 168 TYR A O   1 
ATOM   1379 C  CB  . TYR A 1 172 ? -1.248  -27.692 6.87    1    32.08  ? 168 TYR A CB  1 
ATOM   1380 C  CG  . TYR A 1 172 ? -0.731  -28.501 8.05    1    34.61  ? 168 TYR A CG  1 
ATOM   1381 C  CD1 . TYR A 1 172 ? -1.177  -29.799 8.278   1    35.87  ? 168 TYR A CD1 1 
ATOM   1382 C  CD2 . TYR A 1 172 ? 0.243   -27.994 8.92    1    36.21  ? 168 TYR A CD2 1 
ATOM   1383 C  CE1 . TYR A 1 172 ? -0.696  -30.564 9.333   1    34.16  ? 168 TYR A CE1 1 
ATOM   1384 C  CE2 . TYR A 1 172 ? 0.722   -28.741 9.986   1    34.54  ? 168 TYR A CE2 1 
ATOM   1385 C  CZ  . TYR A 1 172 ? 0.239   -30.027 10.206  1    35.99  ? 168 TYR A CZ  1 
ATOM   1386 O  OH  . TYR A 1 172 ? 0.738   -30.76  11.248  1    33.19  ? 168 TYR A OH  1 
ATOM   1387 N  N   . ARG A 1 173 ? 0.054   -26.588 3.606   1    35.11  ? 169 ARG A N   1 
ATOM   1388 C  CA  . ARG A 1 173 ? -0.19   -25.654 2.524   1    35.54  ? 169 ARG A CA  1 
ATOM   1389 C  C   . ARG A 1 173 ? -0.375  -26.394 1.197   1    35.97  ? 169 ARG A C   1 
ATOM   1390 O  O   . ARG A 1 173 ? 0.396   -27.285 0.867   1    36.94  ? 169 ARG A O   1 
ATOM   1391 C  CB  . ARG A 1 173 ? 0.966   -24.656 2.422   1    35.88  ? 169 ARG A CB  1 
ATOM   1392 C  CG  . ARG A 1 173 ? 0.676   -23.542 1.42    1    35.14  ? 169 ARG A CG  1 
ATOM   1393 C  CD  . ARG A 1 173 ? 1.762   -22.508 1.401   1    35.97  ? 169 ARG A CD  1 
ATOM   1394 N  NE  . ARG A 1 173 ? 2.06    -21.974 2.728   1    33.86  ? 169 ARG A NE  1 
ATOM   1395 C  CZ  . ARG A 1 173 ? 3.183   -21.309 3.006   1    38.35  ? 169 ARG A CZ  1 
ATOM   1396 N  NH1 . ARG A 1 173 ? 4.076   -21.066 2.074   1    37.96  ? 169 ARG A NH1 1 
ATOM   1397 N  NH2 . ARG A 1 173 ? 3.416   -20.913 4.235   1    39     ? 169 ARG A NH2 1 
ATOM   1398 N  N   . ALA A 1 174 ? -1.399  -25.987 0.443   1    33.33  ? 170 ALA A N   1 
ATOM   1399 C  CA  . ALA A 1 174 ? -1.84   -26.684 -0.751  1    34.87  ? 170 ALA A CA  1 
ATOM   1400 C  C   . ALA A 1 174 ? -0.873  -26.437 -1.913  1    37.83  ? 170 ALA A C   1 
ATOM   1401 O  O   . ALA A 1 174 ? -0.314  -25.354 -2.05   1    39.09  ? 170 ALA A O   1 
ATOM   1402 C  CB  . ALA A 1 174 ? -3.253  -26.217 -1.108  1    31.16  ? 170 ALA A CB  1 
ATOM   1403 N  N   . PRO A 1 175 ? -0.763  -27.384 -2.862  1    37.55  ? 171 PRO A N   1 
ATOM   1404 C  CA  . PRO A 1 175 ? 0.083   -27.176 -4.035  1    39.3   ? 171 PRO A CA  1 
ATOM   1405 C  C   . PRO A 1 175 ? -0.158  -25.858 -4.777  1    39.88  ? 171 PRO A C   1 
ATOM   1406 O  O   . PRO A 1 175 ? 0.812   -25.239 -5.255  1    37.63  ? 171 PRO A O   1 
ATOM   1407 C  CB  . PRO A 1 175 ? -0.161  -28.405 -4.933  1    35.95  ? 171 PRO A CB  1 
ATOM   1408 C  CG  . PRO A 1 175 ? -1.437  -28.983 -4.367  1    37.68  ? 171 PRO A CG  1 
ATOM   1409 C  CD  . PRO A 1 175 ? -1.492  -28.658 -2.874  1    33.73  ? 171 PRO A CD  1 
ATOM   1410 N  N   . GLU A 1 176 ? -1.442  -25.464 -4.897  1    37.37  ? 172 GLU A N   1 
ATOM   1411 C  CA  . GLU A 1 176 ? -1.807  -24.305 -5.698  1    40.93  ? 172 GLU A CA  1 
ATOM   1412 C  C   . GLU A 1 176 ? -1.252  -23.024 -5.062  1    43.65  ? 172 GLU A C   1 
ATOM   1413 O  O   . GLU A 1 176 ? -0.924  -22.085 -5.788  1    42.32  ? 172 GLU A O   1 
ATOM   1414 C  CB  . GLU A 1 176 ? -3.297  -24.247 -6.038  1    39.14  ? 172 GLU A CB  1 
ATOM   1415 C  CG  . GLU A 1 176 ? -4.237  -24.237 -4.846  1    39.16  ? 172 GLU A CG  1 
ATOM   1416 C  CD  . GLU A 1 176 ? -4.753  -25.568 -4.3    1    42.56  ? 172 GLU A CD  1 
ATOM   1417 O  OE1 . GLU A 1 176 ? -5.876  -25.623 -3.703  1    37.09  ? 172 GLU A OE1 1 
ATOM   1418 O  OE2 . GLU A 1 176 ? -4.019  -26.549 -4.454  1    35.57  ? 172 GLU A OE2 1 
ATOM   1419 N  N   . ILE A 1 177 ? -1.117  -22.999 -3.715  1    35.74  ? 173 ILE A N   1 
ATOM   1420 C  CA  . ILE A 1 177 ? -0.528  -21.844 -3.055  1    34.9   ? 173 ILE A CA  1 
ATOM   1421 C  C   . ILE A 1 177 ? 0.972   -21.851 -3.313  1    37.26  ? 173 ILE A C   1 
ATOM   1422 O  O   . ILE A 1 177 ? 1.57    -20.843 -3.683  1    41.12  ? 173 ILE A O   1 
ATOM   1423 C  CB  . ILE A 1 177 ? -0.871  -21.818 -1.551  1    38.12  ? 173 ILE A CB  1 
ATOM   1424 C  CG1 . ILE A 1 177 ? -2.413  -21.812 -1.333  1    35.24  ? 173 ILE A CG1 1 
ATOM   1425 C  CG2 . ILE A 1 177 ? -0.212  -20.622 -0.845  1    32.76  ? 173 ILE A CG2 1 
ATOM   1426 C  CD1 . ILE A 1 177 ? -2.853  -22.015 0.098   1    32.69  ? 173 ILE A CD1 1 
ATOM   1427 N  N   . LEU A 1 178 ? 1.573   -23.026 -3.145  1    38.22  ? 174 LEU A N   1 
ATOM   1428 C  CA  . LEU A 1 178 ? 2.997   -23.214 -3.334  1    41.07  ? 174 LEU A CA  1 
ATOM   1429 C  C   . LEU A 1 178 ? 3.402   -22.83  -4.753  1    42.59  ? 174 LEU A C   1 
ATOM   1430 O  O   . LEU A 1 178 ? 4.506   -22.307 -4.951  1    44.74  ? 174 LEU A O   1 
ATOM   1431 C  CB  . LEU A 1 178 ? 3.377   -24.65  -2.972  1    38.99  ? 174 LEU A CB  1 
ATOM   1432 C  CG  . LEU A 1 178 ? 3.358   -24.972 -1.476  1    35.29  ? 174 LEU A CG  1 
ATOM   1433 C  CD1 . LEU A 1 178 ? 3.398   -26.485 -1.288  1    35.14  ? 174 LEU A CD1 1 
ATOM   1434 C  CD2 . LEU A 1 178 ? 4.584   -24.324 -0.859  1    32.03  ? 174 LEU A CD2 1 
ATOM   1435 N  N   . LEU A 1 179 ? 2.51    -23.056 -5.725  1    37.85  ? 175 LEU A N   1 
ATOM   1436 C  CA  . LEU A 1 179 ? 2.869   -22.718 -7.096  1    39.86  ? 175 LEU A CA  1 
ATOM   1437 C  C   . LEU A 1 179 ? 2.479   -21.279 -7.458  1    45.92  ? 175 LEU A C   1 
ATOM   1438 O  O   . LEU A 1 179 ? 2.48    -20.932 -8.637  1    51.39  ? 175 LEU A O   1 
ATOM   1439 C  CB  . LEU A 1 179 ? 2.231   -23.736 -8.027  1    35.45  ? 175 LEU A CB  1 
ATOM   1440 C  CG  . LEU A 1 179 ? 2.784   -25.157 -7.933  1    35.92  ? 175 LEU A CG  1 
ATOM   1441 C  CD1 . LEU A 1 179 ? 1.883   -26.112 -8.702  1    34.98  ? 175 LEU A CD1 1 
ATOM   1442 C  CD2 . LEU A 1 179 ? 4.201   -25.205 -8.448  1    35.99  ? 175 LEU A CD2 1 
ATOM   1443 N  N   . GLY A 1 180 ? 2.151   -20.431 -6.467  1    42.71  ? 176 GLY A N   1 
ATOM   1444 C  CA  . GLY A 1 180 ? 1.955   -19.019 -6.734  1    42.17  ? 176 GLY A CA  1 
ATOM   1445 C  C   . GLY A 1 180 ? 0.68    -18.706 -7.523  1    48.26  ? 176 GLY A C   1 
ATOM   1446 O  O   . GLY A 1 180 ? 0.589   -17.628 -8.126  1    49.32  ? 176 GLY A O   1 
ATOM   1447 N  N   . CYS A 1 181 ? -0.299  -19.631 -7.516  1    43.6   ? 177 CYS A N   1 
ATOM   1448 C  CA  . CYS A 1 181 ? -1.503  -19.493 -8.329  1    44.07  ? 177 CYS A CA  1 
ATOM   1449 C  C   . CYS A 1 181 ? -2.193  -18.167 -8.02   1    44.33  ? 177 CYS A C   1 
ATOM   1450 O  O   . CYS A 1 181 ? -2.173  -17.718 -6.871  1    44     ? 177 CYS A O   1 
ATOM   1451 C  CB  . CYS A 1 181 ? -2.396  -20.731 -8.219  1    46.97  ? 177 CYS A CB  1 
ATOM   1452 S  SG  . CYS A 1 181 ? -1.98   -22.055 -9.421  1    64.64  ? 177 CYS A SG  1 
ATOM   1453 N  N   . LYS A 1 182 ? -2.779  -17.531 -9.048  1    41.29  ? 178 LYS A N   1 
ATOM   1454 C  CA  . LYS A 1 182 ? -3.462  -16.254 -8.863  1    45.34  ? 178 LYS A CA  1 
ATOM   1455 C  C   . LYS A 1 182 ? -4.635  -16.361 -7.875  1    44.26  ? 178 LYS A C   1 
ATOM   1456 O  O   . LYS A 1 182 ? -4.914  -15.435 -7.112  1    42.7   ? 178 LYS A O   1 
ATOM   1457 C  CB  . LYS A 1 182 ? -3.92   -15.762 -10.24  1    50.99  ? 178 LYS A CB  1 
ATOM   1458 C  CG  . LYS A 1 182 ? -4.641  -14.417 -10.266 1    63.96  ? 178 LYS A CG  1 
ATOM   1459 C  CD  . LYS A 1 182 ? -5.003  -13.926 -11.676 1    74.04  ? 178 LYS A CD  1 
ATOM   1460 C  CE  . LYS A 1 182 ? -5.19   -12.414 -11.706 1    82.5   ? 178 LYS A CE  1 
ATOM   1461 N  NZ  . LYS A 1 182 ? -6.192  -11.948 -12.676 1    78.03  ? 178 LYS A NZ  1 
ATOM   1462 N  N   . TYR A 1 183 ? -5.352  -17.491 -7.94   1    41.62  ? 179 TYR A N   1 
ATOM   1463 C  CA  . TYR A 1 183 ? -6.6    -17.661 -7.219  1    41.21  ? 179 TYR A CA  1 
ATOM   1464 C  C   . TYR A 1 183 ? -6.554  -18.965 -6.438  1    40.44  ? 179 TYR A C   1 
ATOM   1465 O  O   . TYR A 1 183 ? -6.061  -19.987 -6.928  1    37.15  ? 179 TYR A O   1 
ATOM   1466 C  CB  . TYR A 1 183 ? -7.778  -17.773 -8.194  1    43.52  ? 179 TYR A CB  1 
ATOM   1467 C  CG  . TYR A 1 183 ? -8.065  -16.536 -9.039  1    45.35  ? 179 TYR A CG  1 
ATOM   1468 C  CD1 . TYR A 1 183 ? -8.224  -15.286 -8.445  1    44.15  ? 179 TYR A CD1 1 
ATOM   1469 C  CD2 . TYR A 1 183 ? -8.185  -16.628 -10.429 1    42.58  ? 179 TYR A CD2 1 
ATOM   1470 C  CE1 . TYR A 1 183 ? -8.493  -14.16  -9.214  1    46.2   ? 179 TYR A CE1 1 
ATOM   1471 C  CE2 . TYR A 1 183 ? -8.469  -15.516 -11.207 1    43.16  ? 179 TYR A CE2 1 
ATOM   1472 C  CZ  . TYR A 1 183 ? -8.606  -14.283 -10.594 1    49.72  ? 179 TYR A CZ  1 
ATOM   1473 O  OH  . TYR A 1 183 ? -8.877  -13.19  -11.348 1    53.83  ? 179 TYR A OH  1 
ATOM   1474 N  N   . TYR A 1 184 ? -7.046  -18.894 -5.196  1    38.23  ? 180 TYR A N   1 
ATOM   1475 C  CA  . TYR A 1 184 ? -7.262  -20.098 -4.424  1    38.45  ? 180 TYR A CA  1 
ATOM   1476 C  C   . TYR A 1 184 ? -8.635  -20.005 -3.76   1    39.85  ? 180 TYR A C   1 
ATOM   1477 O  O   . TYR A 1 184 ? -9.184  -18.912 -3.605  1    39.88  ? 180 TYR A O   1 
ATOM   1478 C  CB  . TYR A 1 184 ? -6.092  -20.394 -3.487  1    36.44  ? 180 TYR A CB  1 
ATOM   1479 C  CG  . TYR A 1 184 ? -5.919  -19.379 -2.366  1    40.75  ? 180 TYR A CG  1 
ATOM   1480 C  CD1 . TYR A 1 184 ? -6.704  -19.406 -1.2    1    35.23  ? 180 TYR A CD1 1 
ATOM   1481 C  CD2 . TYR A 1 184 ? -4.924  -18.416 -2.469  1    38.96  ? 180 TYR A CD2 1 
ATOM   1482 C  CE1 . TYR A 1 184 ? -6.498  -18.483 -0.193  1    36.03  ? 180 TYR A CE1 1 
ATOM   1483 C  CE2 . TYR A 1 184 ? -4.715  -17.497 -1.456  1    38.94  ? 180 TYR A CE2 1 
ATOM   1484 C  CZ  . TYR A 1 184 ? -5.488  -17.532 -0.316  1    40.55  ? 180 TYR A CZ  1 
ATOM   1485 O  OH  . TYR A 1 184 ? -5.206  -16.565 0.619   1    44.46  ? 180 TYR A OH  1 
ATOM   1486 N  N   . SER A 1 185 ? -9.14   -21.172 -3.338  1    35.56  ? 181 SER A N   1 
ATOM   1487 C  CA  . SER A 1 185 ? -10.525 -21.272 -2.921  1    41.14  ? 181 SER A CA  1 
ATOM   1488 C  C   . SER A 1 185 ? -10.641 -22.198 -1.724  1    37.63  ? 181 SER A C   1 
ATOM   1489 O  O   . SER A 1 185 ? -9.649  -22.499 -1.066  1    41.49  ? 181 SER A O   1 
ATOM   1490 C  CB  . SER A 1 185 ? -11.396 -21.772 -4.068  1    37.82  ? 181 SER A CB  1 
ATOM   1491 O  OG  . SER A 1 185 ? -12.728 -21.381 -3.776  1    38.72  ? 181 SER A OG  1 
ATOM   1492 N  N   . THR A 1 186 ? -11.843 -22.746 -1.561  1    35.5   ? 182 THR A N   1 
ATOM   1493 C  CA  . THR A 1 186 ? -12.18  -23.593 -0.426  1    37.77  ? 182 THR A CA  1 
ATOM   1494 C  C   . THR A 1 186 ? -11.325 -24.85  -0.4    1    37.72  ? 182 THR A C   1 
ATOM   1495 O  O   . THR A 1 186 ? -11.16  -25.448 0.66    1    40.69  ? 182 THR A O   1 
ATOM   1496 C  CB  . THR A 1 186 ? -13.664 -23.928 -0.508  1    38     ? 182 THR A CB  1 
ATOM   1497 O  OG1 . THR A 1 186 ? -13.899 -24.364 -1.85   1    35.69  ? 182 THR A OG1 1 
ATOM   1498 C  CG2 . THR A 1 186 ? -14.54  -22.746 -0.127  1    32.59  ? 182 THR A CG2 1 
ATOM   1499 N  N   . ALA A 1 187 ? -10.768 -25.224 -1.559  1    38.32  ? 183 ALA A N   1 
ATOM   1500 C  CA  . ALA A 1 187 ? -9.997  -26.448 -1.71   1    33.46  ? 183 ALA A CA  1 
ATOM   1501 C  C   . ALA A 1 187 ? -8.724  -26.416 -0.862  1    34.89  ? 183 ALA A C   1 
ATOM   1502 O  O   . ALA A 1 187 ? -8.261  -27.462 -0.438  1    38.27  ? 183 ALA A O   1 
ATOM   1503 C  CB  . ALA A 1 187 ? -9.721  -26.703 -3.153  1    28.55  ? 183 ALA A CB  1 
ATOM   1504 N  N   . VAL A 1 188 ? -8.186  -25.227 -0.558  1    36.64  ? 184 VAL A N   1 
ATOM   1505 C  CA  . VAL A 1 188 ? -7.008  -25.139 0.304   1    37.25  ? 184 VAL A CA  1 
ATOM   1506 C  C   . VAL A 1 188 ? -7.333  -25.603 1.744   1    36.79  ? 184 VAL A C   1 
ATOM   1507 O  O   . VAL A 1 188 ? -6.481  -26.196 2.42    1    42.62  ? 184 VAL A O   1 
ATOM   1508 C  CB  . VAL A 1 188 ? -6.332  -23.756 0.319   1    34.8   ? 184 VAL A CB  1 
ATOM   1509 C  CG1 . VAL A 1 188 ? -6.342  -23.099 -1.055  1    34.71  ? 184 VAL A CG1 1 
ATOM   1510 C  CG2 . VAL A 1 188 ? -6.957  -22.862 1.376   1    31.93  ? 184 VAL A CG2 1 
ATOM   1511 N  N   . ASP A 1 189 ? -8.57   -25.392 2.22    1    35.6   ? 185 ASP A N   1 
ATOM   1512 C  CA  . ASP A 1 189 ? -8.901  -25.855 3.561   1    37.47  ? 185 ASP A CA  1 
ATOM   1513 C  C   . ASP A 1 189 ? -9      -27.377 3.552   1    37.96  ? 185 ASP A C   1 
ATOM   1514 O  O   . ASP A 1 189 ? -8.643  -27.996 4.545   1    38.32  ? 185 ASP A O   1 
ATOM   1515 C  CB  . ASP A 1 189 ? -10.137 -25.202 4.154   1    35.06  ? 185 ASP A CB  1 
ATOM   1516 C  CG  . ASP A 1 189 ? -9.953  -23.754 4.572   1    41.81  ? 185 ASP A CG  1 
ATOM   1517 O  OD1 . ASP A 1 189 ? -8.78   -23.367 4.837   1    41.38  ? 185 ASP A OD1 1 
ATOM   1518 O  OD2 . ASP A 1 189 ? -10.988 -23.012 4.609   1    40.83  ? 185 ASP A OD2 1 
ATOM   1519 N  N   . ILE A 1 190 ? -9.446  -27.955 2.427   1    35.27  ? 186 ILE A N   1 
ATOM   1520 C  CA  . ILE A 1 190 ? -9.584  -29.396 2.337   1    37.96  ? 186 ILE A CA  1 
ATOM   1521 C  C   . ILE A 1 190 ? -8.209  -30.072 2.368   1    41.58  ? 186 ILE A C   1 
ATOM   1522 O  O   . ILE A 1 190 ? -7.997  -31.051 3.107   1    42.24  ? 186 ILE A O   1 
ATOM   1523 C  CB  . ILE A 1 190 ? -10.445 -29.811 1.129   1    36.89  ? 186 ILE A CB  1 
ATOM   1524 C  CG1 . ILE A 1 190 ? -11.945 -29.56  1.428   1    37.09  ? 186 ILE A CG1 1 
ATOM   1525 C  CG2 . ILE A 1 190 ? -10.208 -31.279 0.762   1    35.64  ? 186 ILE A CG2 1 
ATOM   1526 C  CD1 . ILE A 1 190 ? -12.533 -30.418 2.547   1    37.01  ? 186 ILE A CD1 1 
ATOM   1527 N  N   . TRP A 1 191 ? -7.276  -29.533 1.578   1    38.59  ? 187 TRP A N   1 
ATOM   1528 C  CA  . TRP A 1 191 ? -5.909  -30.026 1.59    1    40.22  ? 187 TRP A CA  1 
ATOM   1529 C  C   . TRP A 1 191 ? -5.386  -30.127 3.028   1    39.81  ? 187 TRP A C   1 
ATOM   1530 O  O   . TRP A 1 191 ? -4.828  -31.145 3.434   1    43.47  ? 187 TRP A O   1 
ATOM   1531 C  CB  . TRP A 1 191 ? -5      -29.126 0.74    1    38.02  ? 187 TRP A CB  1 
ATOM   1532 C  CG  . TRP A 1 191 ? -3.598  -29.658 0.662   1    36.86  ? 187 TRP A CG  1 
ATOM   1533 C  CD1 . TRP A 1 191 ? -2.586  -29.455 1.557   1    38.79  ? 187 TRP A CD1 1 
ATOM   1534 C  CD2 . TRP A 1 191 ? -3.061  -30.515 -0.364  1    36.12  ? 187 TRP A CD2 1 
ATOM   1535 N  NE1 . TRP A 1 191 ? -1.459  -30.138 1.166   1    40.28  ? 187 TRP A NE1 1 
ATOM   1536 C  CE2 . TRP A 1 191 ? -1.715  -30.771 -0.02   1    37.14  ? 187 TRP A CE2 1 
ATOM   1537 C  CE3 . TRP A 1 191 ? -3.574  -31.064 -1.543  1    34.64  ? 187 TRP A CE3 1 
ATOM   1538 C  CZ2 . TRP A 1 191 ? -0.891  -31.561 -0.808  1    37.49  ? 187 TRP A CZ2 1 
ATOM   1539 C  CZ3 . TRP A 1 191 ? -2.748  -31.841 -2.324  1    36.28  ? 187 TRP A CZ3 1 
ATOM   1540 C  CH2 . TRP A 1 191 ? -1.422  -32.083 -1.966  1    35.48  ? 187 TRP A CH2 1 
ATOM   1541 N  N   . SER A 1 192 ? -5.526  -29.049 3.795   1    38.34  ? 188 SER A N   1 
ATOM   1542 C  CA  . SER A 1 192 ? -5.05   -29.038 5.173   1    37.19  ? 188 SER A CA  1 
ATOM   1543 C  C   . SER A 1 192 ? -5.671  -30.181 5.978   1    33.82  ? 188 SER A C   1 
ATOM   1544 O  O   . SER A 1 192 ? -4.962  -30.966 6.614   1    32.34  ? 188 SER A O   1 
ATOM   1545 C  CB  . SER A 1 192 ? -5.283  -27.71  5.828   1    36.74  ? 188 SER A CB  1 
ATOM   1546 O  OG  . SER A 1 192 ? -4.504  -26.699 5.216   1    35.94  ? 188 SER A OG  1 
ATOM   1547 N  N   . LEU A 1 193 ? -7      -30.326 5.884   1    35.03  ? 189 LEU A N   1 
ATOM   1548 C  CA  . LEU A 1 193 ? -7.692  -31.419 6.556   1    32.81  ? 189 LEU A CA  1 
ATOM   1549 C  C   . LEU A 1 193 ? -7.201  -32.777 6.073   1    36.52  ? 189 LEU A C   1 
ATOM   1550 O  O   . LEU A 1 193 ? -7.21   -33.722 6.853   1    39.36  ? 189 LEU A O   1 
ATOM   1551 C  CB  . LEU A 1 193 ? -9.179  -31.316 6.3     1    33.24  ? 189 LEU A CB  1 
ATOM   1552 C  CG  . LEU A 1 193 ? -9.971  -30.358 7.17    1    38.43  ? 189 LEU A CG  1 
ATOM   1553 C  CD1 . LEU A 1 193 ? -11.422 -30.84  7.151   1    33.32  ? 189 LEU A CD1 1 
ATOM   1554 C  CD2 . LEU A 1 193 ? -9.412  -30.379 8.584   1    43.48  ? 189 LEU A CD2 1 
ATOM   1555 N  N   . GLY A 1 194 ? -6.871  -32.892 4.774   1    37.2   ? 190 GLY A N   1 
ATOM   1556 C  CA  . GLY A 1 194 ? -6.27   -34.095 4.237   1    32.89  ? 190 GLY A CA  1 
ATOM   1557 C  C   . GLY A 1 194 ? -4.978  -34.439 4.976   1    36.96  ? 190 GLY A C   1 
ATOM   1558 O  O   . GLY A 1 194 ? -4.824  -35.558 5.507   1    38     ? 190 GLY A O   1 
ATOM   1559 N  N   . CYS A 1 195 ? -4.066  -33.452 5.013   1    35.26  ? 191 CYS A N   1 
ATOM   1560 C  CA  . CYS A 1 195 ? -2.793  -33.58  5.709   1    31.31  ? 191 CYS A CA  1 
ATOM   1561 C  C   . CYS A 1 195 ? -3.051  -34.018 7.155   1    34.51  ? 191 CYS A C   1 
ATOM   1562 O  O   . CYS A 1 195 ? -2.328  -34.862 7.676   1    33.69  ? 191 CYS A O   1 
ATOM   1563 C  CB  . CYS A 1 195 ? -1.998  -32.287 5.605   1    29.56  ? 191 CYS A CB  1 
ATOM   1564 S  SG  . CYS A 1 195 ? -1.484  -31.864 3.91    1    35.49  ? 191 CYS A SG  1 
ATOM   1565 N  N   . ILE A 1 196 ? -4.099  -33.453 7.796   1    32.69  ? 192 ILE A N   1 
ATOM   1566 C  CA  . ILE A 1 196 ? -4.406  -33.68  9.196   1    33.2   ? 192 ILE A CA  1 
ATOM   1567 C  C   . ILE A 1 196 ? -4.953  -35.092 9.401   1    38.2   ? 192 ILE A C   1 
ATOM   1568 O  O   . ILE A 1 196 ? -4.574  -35.73  10.388  1    41.45  ? 192 ILE A O   1 
ATOM   1569 C  CB  . ILE A 1 196 ? -5.377  -32.608 9.724   1    34.1   ? 192 ILE A CB  1 
ATOM   1570 C  CG1 . ILE A 1 196 ? -4.685  -31.262 9.735   1    34.96  ? 192 ILE A CG1 1 
ATOM   1571 C  CG2 . ILE A 1 196 ? -5.931  -32.977 11.115  1    32.31  ? 192 ILE A CG2 1 
ATOM   1572 C  CD1 . ILE A 1 196 ? -5.586  -30.101 10.055  1    33.12  ? 192 ILE A CD1 1 
ATOM   1573 N  N   . PHE A 1 197 ? -5.836  -35.557 8.492   1    35.52  ? 193 PHE A N   1 
ATOM   1574 C  CA  . PHE A 1 197 ? -6.347  -36.925 8.474   1    38.17  ? 193 PHE A CA  1 
ATOM   1575 C  C   . PHE A 1 197 ? -5.175  -37.905 8.559   1    37.88  ? 193 PHE A C   1 
ATOM   1576 O  O   . PHE A 1 197 ? -5.1    -38.738 9.466   1    40.19  ? 193 PHE A O   1 
ATOM   1577 C  CB  . PHE A 1 197 ? -7.24   -37.149 7.245   1    36.88  ? 193 PHE A CB  1 
ATOM   1578 C  CG  . PHE A 1 197 ? -7.863  -38.519 7.028   1    38.04  ? 193 PHE A CG  1 
ATOM   1579 C  CD1 . PHE A 1 197 ? -7.888  -39.495 8.038   1    38.19  ? 193 PHE A CD1 1 
ATOM   1580 C  CD2 . PHE A 1 197 ? -8.415  -38.844 5.779   1    37.96  ? 193 PHE A CD2 1 
ATOM   1581 C  CE1 . PHE A 1 197 ? -8.469  -40.752 7.806   1    36.9   ? 193 PHE A CE1 1 
ATOM   1582 C  CE2 . PHE A 1 197 ? -9.001  -40.094 5.549   1    33.76  ? 193 PHE A CE2 1 
ATOM   1583 C  CZ  . PHE A 1 197 ? -9.043  -41.04  6.56    1    36.57  ? 193 PHE A CZ  1 
ATOM   1584 N  N   . ALA A 1 198 ? -4.263  -37.786 7.597   1    35.53  ? 194 ALA A N   1 
ATOM   1585 C  CA  . ALA A 1 198 ? -3.089  -38.644 7.539   1    36.13  ? 194 ALA A CA  1 
ATOM   1586 C  C   . ALA A 1 198 ? -2.363  -38.596 8.887   1    37.97  ? 194 ALA A C   1 
ATOM   1587 O  O   . ALA A 1 198 ? -2.007  -39.639 9.434   1    43.87  ? 194 ALA A O   1 
ATOM   1588 C  CB  . ALA A 1 198 ? -2.232  -38.225 6.357   1    31.89  ? 194 ALA A CB  1 
ATOM   1589 N  N   . GLU A 1 199 ? -2.216  -37.386 9.448   1    36.22  ? 195 GLU A N   1 
ATOM   1590 C  CA  . GLU A 1 199 ? -1.409  -37.152 10.632  1    37.47  ? 195 GLU A CA  1 
ATOM   1591 C  C   . GLU A 1 199 ? -2.029  -37.807 11.863  1    41.31  ? 195 GLU A C   1 
ATOM   1592 O  O   . GLU A 1 199 ? -1.319  -38.28  12.736  1    44.63  ? 195 GLU A O   1 
ATOM   1593 C  CB  . GLU A 1 199 ? -1.178  -35.654 10.831  1    36.78  ? 195 GLU A CB  1 
ATOM   1594 C  CG  . GLU A 1 199 ? -0.139  -35.342 11.906  1    37.45  ? 195 GLU A CG  1 
ATOM   1595 C  CD  . GLU A 1 199 ? 0.319   -33.898 11.951  1    37.8   ? 195 GLU A CD  1 
ATOM   1596 O  OE1 . GLU A 1 199 ? 0.107   -33.241 10.914  1    34.36  ? 195 GLU A OE1 1 
ATOM   1597 O  OE2 . GLU A 1 199 ? 0.836   -33.432 13.015  1    41.84  ? 195 GLU A OE2 1 
ATOM   1598 N  N   . MET A 1 200 ? -3.358  -37.843 11.929  1    43.62  ? 196 MET A N   1 
ATOM   1599 C  CA  . MET A 1 200 ? -4.054  -38.514 13.017  1    44.36  ? 196 MET A CA  1 
ATOM   1600 C  C   . MET A 1 200 ? -3.793  -40.019 13.015  1    46.39  ? 196 MET A C   1 
ATOM   1601 O  O   . MET A 1 200 ? -3.856  -40.628 14.083  1    51.75  ? 196 MET A O   1 
ATOM   1602 C  CB  . MET A 1 200 ? -5.571  -38.272 12.912  1    46.71  ? 196 MET A CB  1 
ATOM   1603 C  CG  . MET A 1 200 ? -5.99   -36.874 13.396  1    42.43  ? 196 MET A CG  1 
ATOM   1604 S  SD  . MET A 1 200 ? -7.755  -36.686 13.666  1    40.46  ? 196 MET A SD  1 
ATOM   1605 C  CE  . MET A 1 200 ? -8.29   -36.726 11.957  1    33.34  ? 196 MET A CE  1 
ATOM   1606 N  N   . VAL A 1 201 ? -3.541  -40.6   11.826  1    44.08  ? 197 VAL A N   1 
ATOM   1607 C  CA  . VAL A 1 201 ? -3.359  -42.033 11.646  1    46.25  ? 197 VAL A CA  1 
ATOM   1608 C  C   . VAL A 1 201 ? -1.935  -42.396 12.067  1    46.93  ? 197 VAL A C   1 
ATOM   1609 O  O   . VAL A 1 201 ? -1.724  -43.34  12.817  1    49.7   ? 197 VAL A O   1 
ATOM   1610 C  CB  . VAL A 1 201 ? -3.702  -42.549 10.222  1    41.91  ? 197 VAL A CB  1 
ATOM   1611 C  CG1 . VAL A 1 201 ? -3.347  -44.01  10.06   1    38.2   ? 197 VAL A CG1 1 
ATOM   1612 C  CG2 . VAL A 1 201 ? -5.164  -42.39  9.853   1    34.39  ? 197 VAL A CG2 1 
ATOM   1613 N  N   . THR A 1 202 ? -0.964  -41.605 11.597  1    49.86  ? 198 THR A N   1 
ATOM   1614 C  CA  . THR A 1 202 ? 0.457   -41.91  11.773  1    49.61  ? 198 THR A CA  1 
ATOM   1615 C  C   . THR A 1 202 ? 1.023   -41.187 12.993  1    48.27  ? 198 THR A C   1 
ATOM   1616 O  O   . THR A 1 202 ? 2.017   -41.612 13.542  1    55.68  ? 198 THR A O   1 
ATOM   1617 C  CB  . THR A 1 202 ? 1.25    -41.51  10.528  1    50.31  ? 198 THR A CB  1 
ATOM   1618 O  OG1 . THR A 1 202 ? 1.219   -40.083 10.495  1    56     ? 198 THR A OG1 1 
ATOM   1619 C  CG2 . THR A 1 202 ? 0.646   -42.032 9.239   1    50.66  ? 198 THR A CG2 1 
ATOM   1620 N  N   . ARG A 1 203 ? 0.414   -40.07  13.383  1    50.52  ? 199 ARG A N   1 
ATOM   1621 C  CA  . ARG A 1 203 ? 0.933   -39.228 14.499  1    54.71  ? 199 ARG A CA  1 
ATOM   1622 C  C   . ARG A 1 203 ? 2.21    -38.537 14.001  1    52.08  ? 199 ARG A C   1 
ATOM   1623 O  O   . ARG A 1 203 ? 3.007   -38.097 14.836  1    53.8   ? 199 ARG A O   1 
ATOM   1624 C  CB  . ARG A 1 203 ? 1.066   -39.969 15.835  1    61.47  ? 199 ARG A CB  1 
ATOM   1625 C  CG  . ARG A 1 203 ? -0.238  -40.05  16.612  1    70.35  ? 199 ARG A CG  1 
ATOM   1626 C  CD  . ARG A 1 203 ? -0.735  -41.478 16.625  1    73.48  ? 199 ARG A CD  1 
ATOM   1627 N  NE  . ARG A 1 203 ? 0.325   -42.384 17.076  1    78.03  ? 199 ARG A NE  1 
ATOM   1628 C  CZ  . ARG A 1 203 ? 0.674   -43.502 16.459  1    77.66  ? 199 ARG A CZ  1 
ATOM   1629 N  NH1 . ARG A 1 203 ? 1.786   -44.122 16.803  1    82.02  ? 199 ARG A NH1 1 
ATOM   1630 N  NH2 . ARG A 1 203 ? -0.088  -43.996 15.504  1    77.44  ? 199 ARG A NH2 1 
ATOM   1631 N  N   . ARG A 1 204 ? 2.359   -38.432 12.682  1    49.32  ? 200 ARG A N   1 
ATOM   1632 C  CA  . ARG A 1 204 ? 3.52    -37.744 12.066  1    50.12  ? 200 ARG A CA  1 
ATOM   1633 C  C   . ARG A 1 204 ? 3.017   -36.874 10.905  1    46.85  ? 200 ARG A C   1 
ATOM   1634 O  O   . ARG A 1 204 ? 2.093   -37.31  10.206  1    45.05  ? 200 ARG A O   1 
ATOM   1635 C  CB  . ARG A 1 204 ? 4.523   -38.803 11.602  1    53.85  ? 200 ARG A CB  1 
ATOM   1636 C  CG  . ARG A 1 204 ? 5.129   -38.67  10.214  1    58.6   ? 200 ARG A CG  1 
ATOM   1637 C  CD  . ARG A 1 204 ? 4.607   -39.736 9.267   1    66.34  ? 200 ARG A CD  1 
ATOM   1638 N  NE  . ARG A 1 204 ? 5.412   -40.96  9.321   1    65.33  ? 200 ARG A NE  1 
ATOM   1639 C  CZ  . ARG A 1 204 ? 6.461   -41.2   8.55    1    63.16  ? 200 ARG A CZ  1 
ATOM   1640 N  NH1 . ARG A 1 204 ? 7.68    -41.038 9.026   1    57.77  ? 200 ARG A NH1 1 
ATOM   1641 N  NH2 . ARG A 1 204 ? 6.289   -41.6   7.306   1    67.54  ? 200 ARG A NH2 1 
ATOM   1642 N  N   . ALA A 1 205 ? 3.594   -35.689 10.723  1    44.03  ? 201 ALA A N   1 
ATOM   1643 C  CA  . ALA A 1 205 ? 3.205   -34.807 9.603   1    43.26  ? 201 ALA A CA  1 
ATOM   1644 C  C   . ALA A 1 205 ? 3.442   -35.518 8.278   1    44.19  ? 201 ALA A C   1 
ATOM   1645 O  O   . ALA A 1 205 ? 4.464   -36.195 8.124   1    46.87  ? 201 ALA A O   1 
ATOM   1646 C  CB  . ALA A 1 205 ? 3.964   -33.515 9.662   1    36.42  ? 201 ALA A CB  1 
ATOM   1647 N  N   . LEU A 1 206 ? 2.519   -35.345 7.344   1    41.29  ? 202 LEU A N   1 
ATOM   1648 C  CA  . LEU A 1 206 ? 2.63    -36.047 6.079   1    42.61  ? 202 LEU A CA  1 
ATOM   1649 C  C   . LEU A 1 206 ? 3.652   -35.393 5.145   1    41.33  ? 202 LEU A C   1 
ATOM   1650 O  O   . LEU A 1 206 ? 4.336   -36.087 4.404   1    44.63  ? 202 LEU A O   1 
ATOM   1651 C  CB  . LEU A 1 206 ? 1.233   -36.044 5.445   1    42.8   ? 202 LEU A CB  1 
ATOM   1652 C  CG  . LEU A 1 206 ? 1.114   -36.77  4.099   1    42.2   ? 202 LEU A CG  1 
ATOM   1653 C  CD1 . LEU A 1 206 ? 1.341   -38.268 4.301   1    38.68  ? 202 LEU A CD1 1 
ATOM   1654 C  CD2 . LEU A 1 206 ? -0.238  -36.457 3.511   1    38.27  ? 202 LEU A CD2 1 
ATOM   1655 N  N   . PHE A 1 207 ? 3.735   -34.056 5.136   1    39.19  ? 203 PHE A N   1 
ATOM   1656 C  CA  . PHE A 1 207 ? 4.707   -33.391 4.275   1    37.67  ? 203 PHE A CA  1 
ATOM   1657 C  C   . PHE A 1 207 ? 5.482   -32.36  5.089   1    39.69  ? 203 PHE A C   1 
ATOM   1658 O  O   . PHE A 1 207 ? 5.181   -31.166 5.025   1    47.85  ? 203 PHE A O   1 
ATOM   1659 C  CB  . PHE A 1 207 ? 3.939   -32.692 3.151   1    36.15  ? 203 PHE A CB  1 
ATOM   1660 C  CG  . PHE A 1 207 ? 3.019   -33.592 2.34    1    35.1   ? 203 PHE A CG  1 
ATOM   1661 C  CD1 . PHE A 1 207 ? 3.522   -34.705 1.681   1    34.82  ? 203 PHE A CD1 1 
ATOM   1662 C  CD2 . PHE A 1 207 ? 1.666   -33.31  2.223   1    33.98  ? 203 PHE A CD2 1 
ATOM   1663 C  CE1 . PHE A 1 207 ? 2.694   -35.491 0.906   1    36.18  ? 203 PHE A CE1 1 
ATOM   1664 C  CE2 . PHE A 1 207 ? 0.832   -34.125 1.469   1    36.32  ? 203 PHE A CE2 1 
ATOM   1665 C  CZ  . PHE A 1 207 ? 1.357   -35.2   0.778   1    34.54  ? 203 PHE A CZ  1 
ATOM   1666 N  N   . PRO A 1 208 ? 6.49    -32.755 5.89    1    37.08  ? 204 PRO A N   1 
ATOM   1667 C  CA  . PRO A 1 208 ? 7.178   -31.783 6.743   1    36.9   ? 204 PRO A CA  1 
ATOM   1668 C  C   . PRO A 1 208 ? 8.37    -31.147 6.056   1    38.58  ? 204 PRO A C   1 
ATOM   1669 O  O   . PRO A 1 208 ? 9.504   -31.456 6.411   1    43.95  ? 204 PRO A O   1 
ATOM   1670 C  CB  . PRO A 1 208 ? 7.635   -32.694 7.912   1    35.59  ? 204 PRO A CB  1 
ATOM   1671 C  CG  . PRO A 1 208 ? 7.984   -34.048 7.226   1    33.95  ? 204 PRO A CG  1 
ATOM   1672 C  CD  . PRO A 1 208 ? 7.008   -34.137 6.036   1    35.84  ? 204 PRO A CD  1 
ATOM   1673 N  N   . GLY A 1 209 ? 8.111   -30.259 5.093   1    41.56  ? 205 GLY A N   1 
ATOM   1674 C  CA  . GLY A 1 209 ? 9.181   -29.589 4.36    1    46.93  ? 205 GLY A CA  1 
ATOM   1675 C  C   . GLY A 1 209 ? 9.746   -28.403 5.141   1    50.03  ? 205 GLY A C   1 
ATOM   1676 O  O   . GLY A 1 209 ? 9.065   -27.878 6.018   1    49.89  ? 205 GLY A O   1 
ATOM   1677 N  N   . ASP A 1 210 ? 10.962  -27.958 4.792   1    57.67  ? 206 ASP A N   1 
ATOM   1678 C  CA  . ASP A 1 210 ? 11.62   -26.865 5.507   1    67.62  ? 206 ASP A CA  1 
ATOM   1679 C  C   . ASP A 1 210 ? 11.793  -25.641 4.613   1    58.16  ? 206 ASP A C   1 
ATOM   1680 O  O   . ASP A 1 210 ? 12.438  -24.685 5.033   1    64.97  ? 206 ASP A O   1 
ATOM   1681 C  CB  . ASP A 1 210 ? 12.881  -27.315 6.229   1    69.48  ? 206 ASP A CB  1 
ATOM   1682 C  CG  . ASP A 1 210 ? 13.968  -27.776 5.277   1    83.59  ? 206 ASP A CG  1 
ATOM   1683 O  OD1 . ASP A 1 210 ? 13.781  -27.575 4.06    1    99.12  ? 206 ASP A OD1 1 
ATOM   1684 O  OD2 . ASP A 1 210 ? 14.966  -28.365 5.753   1    79.45  ? 206 ASP A OD2 1 
ATOM   1685 N  N   . SER A 1 211 ? 11.148  -25.657 3.435   1    48.69  ? 207 SER A N   1 
ATOM   1686 C  CA  . SER A 1 211 ? 11.04   -24.482 2.577   1    45.9   ? 207 SER A CA  1 
ATOM   1687 C  C   . SER A 1 211 ? 9.899   -24.669 1.593   1    42.88  ? 207 SER A C   1 
ATOM   1688 O  O   . SER A 1 211 ? 9.454   -25.797 1.41    1    43.47  ? 207 SER A O   1 
ATOM   1689 C  CB  . SER A 1 211 ? 12.331  -24.238 1.845   1    47.26  ? 207 SER A CB  1 
ATOM   1690 O  OG  . SER A 1 211 ? 12.709  -25.408 1.139   1    47.85  ? 207 SER A OG  1 
ATOM   1691 N  N   . GLU A 1 212 ? 9.443   -23.593 0.936   1    41.31  ? 208 GLU A N   1 
ATOM   1692 C  CA  . GLU A 1 212 ? 8.439   -23.777 -0.105  1    42.9   ? 208 GLU A CA  1 
ATOM   1693 C  C   . GLU A 1 212 ? 8.839   -24.897 -1.074  1    40.88  ? 208 GLU A C   1 
ATOM   1694 O  O   . GLU A 1 212 ? 8.05    -25.799 -1.358  1    41.2   ? 208 GLU A O   1 
ATOM   1695 C  CB  . GLU A 1 212 ? 8.208   -22.484 -0.887  1    47.78  ? 208 GLU A CB  1 
ATOM   1696 C  CG  . GLU A 1 212 ? 7.273   -21.488 -0.208  1    51.73  ? 208 GLU A CG  1 
ATOM   1697 C  CD  . GLU A 1 212 ? 7.122   -20.162 -0.941  1    56.31  ? 208 GLU A CD  1 
ATOM   1698 O  OE1 . GLU A 1 212 ? 6.075   -19.859 -1.553  1    61.96  ? 208 GLU A OE1 1 
ATOM   1699 O  OE2 . GLU A 1 212 ? 8.107   -19.4   -0.878  1    64.73  ? 208 GLU A OE2 1 
ATOM   1700 N  N   . ILE A 1 213 ? 10.063  -24.842 -1.604  1    41.82  ? 209 ILE A N   1 
ATOM   1701 C  CA  . ILE A 1 213 ? 10.408  -25.726 -2.709  1    46.09  ? 209 ILE A CA  1 
ATOM   1702 C  C   . ILE A 1 213 ? 10.566  -27.175 -2.217  1    46.15  ? 209 ILE A C   1 
ATOM   1703 O  O   . ILE A 1 213 ? 10.237  -28.124 -2.931  1    45.97  ? 209 ILE A O   1 
ATOM   1704 C  CB  . ILE A 1 213 ? 11.617  -25.206 -3.52   1    45.62  ? 209 ILE A CB  1 
ATOM   1705 C  CG1 . ILE A 1 213 ? 11.79   -25.957 -4.834  1    46     ? 209 ILE A CG1 1 
ATOM   1706 C  CG2 . ILE A 1 213 ? 12.883  -25.312 -2.693  1    50.19  ? 209 ILE A CG2 1 
ATOM   1707 C  CD1 . ILE A 1 213 ? 10.704  -25.671 -5.86   1    41.99  ? 209 ILE A CD1 1 
ATOM   1708 N  N   . ASP A 1 214 ? 11.072  -27.342 -0.99   1    46.32  ? 210 ASP A N   1 
ATOM   1709 C  CA  . ASP A 1 214 ? 11.165  -28.642 -0.349  1    43.99  ? 210 ASP A CA  1 
ATOM   1710 C  C   . ASP A 1 214 ? 9.787   -29.218 -0.069  1    45.28  ? 210 ASP A C   1 
ATOM   1711 O  O   . ASP A 1 214 ? 9.586   -30.423 -0.214  1    48.8   ? 210 ASP A O   1 
ATOM   1712 C  CB  . ASP A 1 214 ? 11.917  -28.568 0.967   1    48.39  ? 210 ASP A CB  1 
ATOM   1713 C  CG  . ASP A 1 214 ? 12.162  -29.918 1.625   1    56.28  ? 210 ASP A CG  1 
ATOM   1714 O  OD1 . ASP A 1 214 ? 12.632  -30.875 0.902   1    55.64  ? 210 ASP A OD1 1 
ATOM   1715 O  OD2 . ASP A 1 214 ? 11.878  -30.006 2.841   1    50.55  ? 210 ASP A OD2 1 
ATOM   1716 N  N   . GLN A 1 215 ? 8.849   -28.356 0.36    1    44.81  ? 211 GLN A N   1 
ATOM   1717 C  CA  . GLN A 1 215 ? 7.461   -28.742 0.583   1    41.68  ? 211 GLN A CA  1 
ATOM   1718 C  C   . GLN A 1 215 ? 6.891   -29.336 -0.715  1    41.17  ? 211 GLN A C   1 
ATOM   1719 O  O   . GLN A 1 215 ? 6.321   -30.417 -0.692  1    43.43  ? 211 GLN A O   1 
ATOM   1720 C  CB  . GLN A 1 215 ? 6.626   -27.554 1.073   1    38.09  ? 211 GLN A CB  1 
ATOM   1721 C  CG  . GLN A 1 215 ? 5.238   -27.94  1.573   1    36.13  ? 211 GLN A CG  1 
ATOM   1722 C  CD  . GLN A 1 215 ? 5.321   -28.754 2.845   1    40.2   ? 211 GLN A CD  1 
ATOM   1723 O  OE1 . GLN A 1 215 ? 6.31    -28.683 3.586   1    42.8   ? 211 GLN A OE1 1 
ATOM   1724 N  NE2 . GLN A 1 215 ? 4.306   -29.558 3.106   1    35.17  ? 211 GLN A NE2 1 
ATOM   1725 N  N   . LEU A 1 216 ? 7.073   -28.645 -1.846  1    37.52  ? 212 LEU A N   1 
ATOM   1726 C  CA  . LEU A 1 216 ? 6.541   -29.115 -3.113  1    38.75  ? 212 LEU A CA  1 
ATOM   1727 C  C   . LEU A 1 216 ? 7.108   -30.482 -3.425  1    40.1   ? 212 LEU A C   1 
ATOM   1728 O  O   . LEU A 1 216 ? 6.373   -31.364 -3.851  1    38.42  ? 212 LEU A O   1 
ATOM   1729 C  CB  . LEU A 1 216 ? 6.923   -28.199 -4.277  1    41.58  ? 212 LEU A CB  1 
ATOM   1730 C  CG  . LEU A 1 216 ? 5.928   -27.089 -4.594  1    47.56  ? 212 LEU A CG  1 
ATOM   1731 C  CD1 . LEU A 1 216 ? 6.575   -26.21  -5.657  1    48.89  ? 212 LEU A CD1 1 
ATOM   1732 C  CD2 . LEU A 1 216 ? 4.587   -27.693 -5.046  1    40.93  ? 212 LEU A CD2 1 
ATOM   1733 N  N   . PHE A 1 217 ? 8.442   -30.578 -3.289  1    40.72  ? 213 PHE A N   1 
ATOM   1734 C  CA  . PHE A 1 217 ? 9.166   -31.776 -3.65   1    38.44  ? 213 PHE A CA  1 
ATOM   1735 C  C   . PHE A 1 217 ? 8.645   -32.948 -2.825  1    43.9   ? 213 PHE A C   1 
ATOM   1736 O  O   . PHE A 1 217 ? 8.409   -34.011 -3.4    1    53.44  ? 213 PHE A O   1 
ATOM   1737 C  CB  . PHE A 1 217 ? 10.673  -31.548 -3.642  1    36.94  ? 213 PHE A CB  1 
ATOM   1738 C  CG  . PHE A 1 217 ? 11.183  -30.764 -4.84   1    38.03  ? 213 PHE A CG  1 
ATOM   1739 C  CD1 . PHE A 1 217 ? 10.306  -30.216 -5.777  1    35.55  ? 213 PHE A CD1 1 
ATOM   1740 C  CD2 . PHE A 1 217 ? 12.544  -30.551 -5.016  1    39.65  ? 213 PHE A CD2 1 
ATOM   1741 C  CE1 . PHE A 1 217 ? 10.792  -29.491 -6.846  1    35.88  ? 213 PHE A CE1 1 
ATOM   1742 C  CE2 . PHE A 1 217 ? 13.023  -29.822 -6.108  1    39.47  ? 213 PHE A CE2 1 
ATOM   1743 C  CZ  . PHE A 1 217 ? 12.139  -29.297 -7.019  1    36.85  ? 213 PHE A CZ  1 
ATOM   1744 N  N   . ARG A 1 218 ? 8.396   -32.75  -1.517  1    38.95  ? 214 ARG A N   1 
ATOM   1745 C  CA  . ARG A 1 218 ? 7.94    -33.86  -0.687  1    41.87  ? 214 ARG A CA  1 
ATOM   1746 C  C   . ARG A 1 218 ? 6.562   -34.33  -1.141  1    39.07  ? 214 ARG A C   1 
ATOM   1747 O  O   . ARG A 1 218 ? 6.274   -35.516 -1.062  1    43.3   ? 214 ARG A O   1 
ATOM   1748 C  CB  . ARG A 1 218 ? 7.896   -33.521 0.812   1    40.74  ? 214 ARG A CB  1 
ATOM   1749 C  CG  . ARG A 1 218 ? 9.241   -33.58  1.512   1    43.3   ? 214 ARG A CG  1 
ATOM   1750 C  CD  . ARG A 1 218 ? 9.193   -32.764 2.769   1    43.28  ? 214 ARG A CD  1 
ATOM   1751 N  NE  . ARG A 1 218 ? 10.532  -32.623 3.365   1    45.23  ? 214 ARG A NE  1 
ATOM   1752 C  CZ  . ARG A 1 218 ? 11.038  -33.496 4.24    1    43.66  ? 214 ARG A CZ  1 
ATOM   1753 N  NH1 . ARG A 1 218 ? 10.359  -34.612 4.498   1    46.03  ? 214 ARG A NH1 1 
ATOM   1754 N  NH2 . ARG A 1 218 ? 12.181  -33.239 4.841   1    37.33  ? 214 ARG A NH2 1 
ATOM   1755 N  N   . ILE A 1 219 ? 5.712   -33.378 -1.546  1    36.73  ? 215 ILE A N   1 
ATOM   1756 C  CA  . ILE A 1 219 ? 4.38    -33.669 -2.037  1    38.45  ? 215 ILE A CA  1 
ATOM   1757 C  C   . ILE A 1 219 ? 4.479   -34.48  -3.337  1    39.96  ? 215 ILE A C   1 
ATOM   1758 O  O   . ILE A 1 219 ? 3.883   -35.562 -3.428  1    39.46  ? 215 ILE A O   1 
ATOM   1759 C  CB  . ILE A 1 219 ? 3.586   -32.374 -2.232  1    36.28  ? 215 ILE A CB  1 
ATOM   1760 C  CG1 . ILE A 1 219 ? 3.304   -31.702 -0.897  1    35.34  ? 215 ILE A CG1 1 
ATOM   1761 C  CG2 . ILE A 1 219 ? 2.295   -32.673 -3.007  1    32.36  ? 215 ILE A CG2 1 
ATOM   1762 C  CD1 . ILE A 1 219 ? 2.728   -30.295 -1.008  1    36.35  ? 215 ILE A CD1 1 
ATOM   1763 N  N   . PHE A 1 220 ? 5.25    -33.956 -4.301  1    37.7   ? 216 PHE A N   1 
ATOM   1764 C  CA  . PHE A 1 220 ? 5.523   -34.588 -5.594  1    40.33  ? 216 PHE A CA  1 
ATOM   1765 C  C   . PHE A 1 220 ? 6.049   -36.021 -5.448  1    39.65  ? 216 PHE A C   1 
ATOM   1766 O  O   . PHE A 1 220 ? 5.637   -36.903 -6.204  1    39.44  ? 216 PHE A O   1 
ATOM   1767 C  CB  . PHE A 1 220 ? 6.555   -33.794 -6.402  1    37.47  ? 216 PHE A CB  1 
ATOM   1768 C  CG  . PHE A 1 220 ? 6.083   -32.455 -6.956  1    38.83  ? 216 PHE A CG  1 
ATOM   1769 C  CD1 . PHE A 1 220 ? 4.815   -31.958 -6.667  1    34.4   ? 216 PHE A CD1 1 
ATOM   1770 C  CD2 . PHE A 1 220 ? 6.928   -31.699 -7.767  1    41.42  ? 216 PHE A CD2 1 
ATOM   1771 C  CE1 . PHE A 1 220 ? 4.408   -30.754 -7.195  1    37.47  ? 216 PHE A CE1 1 
ATOM   1772 C  CE2 . PHE A 1 220 ? 6.496   -30.492 -8.307  1    41.73  ? 216 PHE A CE2 1 
ATOM   1773 C  CZ  . PHE A 1 220 ? 5.252   -30.01  -7.997  1    39.02  ? 216 PHE A CZ  1 
ATOM   1774 N  N   . ARG A 1 221 ? 6.961   -36.242 -4.498  1    38     ? 217 ARG A N   1 
ATOM   1775 C  CA  . ARG A 1 221 ? 7.549   -37.595 -4.308  1    38.85  ? 217 ARG A CA  1 
ATOM   1776 C  C   . ARG A 1 221 ? 6.476   -38.549 -3.769  1    41.44  ? 217 ARG A C   1 
ATOM   1777 O  O   . ARG A 1 221 ? 6.613   -39.773 -3.979  1    48.85  ? 217 ARG A O   1 
ATOM   1778 C  CB  . ARG A 1 221 ? 8.717   -37.53  -3.32   1    37.58  ? 217 ARG A CB  1 
ATOM   1779 C  CG  . ARG A 1 221 ? 9.954   -36.853 -3.888  1    38.38  ? 217 ARG A CG  1 
ATOM   1780 C  CD  . ARG A 1 221 ? 11.034  -36.67  -2.84   1    41.36  ? 217 ARG A CD  1 
ATOM   1781 N  NE  . ARG A 1 221 ? 10.824  -35.459 -2.04   1    52.38  ? 217 ARG A NE  1 
ATOM   1782 C  CZ  . ARG A 1 221 ? 11.689  -34.457 -1.971  1    49.24  ? 217 ARG A CZ  1 
ATOM   1783 N  NH1 . ARG A 1 221 ? 11.652  -33.617 -0.953  1    43.16  ? 217 ARG A NH1 1 
ATOM   1784 N  NH2 . ARG A 1 221 ? 12.589  -34.299 -2.926  1    41.36  ? 217 ARG A NH2 1 
ATOM   1785 N  N   . THR A 1 222 ? 5.449   -38.01  -3.111  1    41.95  ? 218 THR A N   1 
ATOM   1786 C  CA  . THR A 1 222 ? 4.406   -38.825 -2.503  1    41.38  ? 218 THR A CA  1 
ATOM   1787 C  C   . THR A 1 222 ? 3.263   -39.074 -3.491  1    39.82  ? 218 THR A C   1 
ATOM   1788 O  O   . THR A 1 222 ? 2.734   -40.173 -3.54   1    48.45  ? 218 THR A O   1 
ATOM   1789 C  CB  . THR A 1 222 ? 3.885   -38.143 -1.224  1    42.16  ? 218 THR A CB  1 
ATOM   1790 O  OG1 . THR A 1 222 ? 4.992   -38.04  -0.336  1    41.64  ? 218 THR A OG1 1 
ATOM   1791 C  CG2 . THR A 1 222 ? 2.722   -38.882 -0.573  1    38.66  ? 218 THR A CG2 1 
ATOM   1792 N  N   . LEU A 1 223 ? 2.827   -38.043 -4.212  1    34.87  ? 219 LEU A N   1 
ATOM   1793 C  CA  . LEU A 1 223 ? 1.618   -38.138 -5.008  1    36.79  ? 219 LEU A CA  1 
ATOM   1794 C  C   . LEU A 1 223 ? 1.967   -38.144 -6.493  1    39.51  ? 219 LEU A C   1 
ATOM   1795 O  O   . LEU A 1 223 ? 1.056   -38.116 -7.318  1    41.09  ? 219 LEU A O   1 
ATOM   1796 C  CB  . LEU A 1 223 ? 0.739   -36.923 -4.69   1    35.77  ? 219 LEU A CB  1 
ATOM   1797 C  CG  . LEU A 1 223 ? 0.303   -36.783 -3.225  1    37.37  ? 219 LEU A CG  1 
ATOM   1798 C  CD1 . LEU A 1 223 ? -0.561  -35.575 -3.025  1    33.11  ? 219 LEU A CD1 1 
ATOM   1799 C  CD2 . LEU A 1 223 ? -0.453  -38.026 -2.762  1    42.5   ? 219 LEU A CD2 1 
ATOM   1800 N  N   . GLY A 1 224 ? 3.275   -38.093 -6.792  1    37.83  ? 220 GLY A N   1 
ATOM   1801 C  CA  . GLY A 1 224 ? 3.815   -37.992 -8.131  1    35.88  ? 220 GLY A CA  1 
ATOM   1802 C  C   . GLY A 1 224 ? 3.839   -36.534 -8.552  1    37.54  ? 220 GLY A C   1 
ATOM   1803 O  O   . GLY A 1 224 ? 3.084   -35.738 -8.007  1    35.77  ? 220 GLY A O   1 
ATOM   1804 N  N   . THR A 1 225 ? 4.715   -36.201 -9.515  1    37.08  ? 221 THR A N   1 
ATOM   1805 C  CA  . THR A 1 225 ? 4.847   -34.826 -9.966  1    41.6   ? 221 THR A CA  1 
ATOM   1806 C  C   . THR A 1 225 ? 3.69    -34.601 -10.92  1    44.94  ? 221 THR A C   1 
ATOM   1807 O  O   . THR A 1 225 ? 3.522   -35.347 -11.873 1    48.62  ? 221 THR A O   1 
ATOM   1808 C  CB  . THR A 1 225 ? 6.174   -34.565 -10.683 1    47.75  ? 221 THR A CB  1 
ATOM   1809 O  OG1 . THR A 1 225 ? 7.308   -34.914 -9.897  1    48.91  ? 221 THR A OG1 1 
ATOM   1810 C  CG2 . THR A 1 225 ? 6.338   -33.123 -11.122 1    47.35  ? 221 THR A CG2 1 
ATOM   1811 N  N   . PRO A 1 226 ? 2.86    -33.571 -10.705 1    46.07  ? 222 PRO A N   1 
ATOM   1812 C  CA  . PRO A 1 226 ? 1.678   -33.378 -11.549 1    44.7   ? 222 PRO A CA  1 
ATOM   1813 C  C   . PRO A 1 226 ? 2.058   -32.857 -12.932 1    44.06  ? 222 PRO A C   1 
ATOM   1814 O  O   . PRO A 1 226 ? 3.067   -32.164 -13.093 1    43.83  ? 222 PRO A O   1 
ATOM   1815 C  CB  . PRO A 1 226 ? 0.898   -32.344 -10.747 1    45.03  ? 222 PRO A CB  1 
ATOM   1816 C  CG  . PRO A 1 226 ? 1.986   -31.525 -10.069 1    44.75  ? 222 PRO A CG  1 
ATOM   1817 C  CD  . PRO A 1 226 ? 3.044   -32.544 -9.674  1    44.33  ? 222 PRO A CD  1 
ATOM   1818 N  N   . ASP A 1 227 ? 1.247   -33.248 -13.925 1    46.87  ? 223 ASP A N   1 
ATOM   1819 C  CA  . ASP A 1 227 ? 1.378   -32.84  -15.32  1    50     ? 223 ASP A CA  1 
ATOM   1820 C  C   . ASP A 1 227 ? 0.004   -32.352 -15.795 1    50.69  ? 223 ASP A C   1 
ATOM   1821 O  O   . ASP A 1 227 ? -0.936  -32.313 -15.007 1    41.61  ? 223 ASP A O   1 
ATOM   1822 C  CB  . ASP A 1 227 ? 1.87    -33.987 -16.195 1    49.32  ? 223 ASP A CB  1 
ATOM   1823 C  CG  . ASP A 1 227 ? 0.979   -35.215 -16.109 1    53.8   ? 223 ASP A CG  1 
ATOM   1824 O  OD1 . ASP A 1 227 ? -0.235  -35.037 -15.954 1    62.47  ? 223 ASP A OD1 1 
ATOM   1825 O  OD2 . ASP A 1 227 ? 1.479   -36.33  -16.247 1    62.21  ? 223 ASP A OD2 1 
ATOM   1826 N  N   . GLU A 1 228 ? -0.116  -32.058 -17.101 1    51.77  ? 224 GLU A N   1 
ATOM   1827 C  CA  . GLU A 1 228 ? -1.321  -31.492 -17.686 1    51.66  ? 224 GLU A CA  1 
ATOM   1828 C  C   . GLU A 1 228 ? -2.486  -32.485 -17.607 1    50.44  ? 224 GLU A C   1 
ATOM   1829 O  O   . GLU A 1 228 ? -3.639  -32.062 -17.505 1    51.62  ? 224 GLU A O   1 
ATOM   1830 C  CB  . GLU A 1 228 ? -1.025  -30.977 -19.1   1    50.11  ? 224 GLU A CB  1 
ATOM   1831 C  CG  . GLU A 1 228 ? -0.208  -29.696 -19.121 1    50.12  ? 224 GLU A CG  1 
ATOM   1832 C  CD  . GLU A 1 228 ? -0.979  -28.469 -18.639 1    62.35  ? 224 GLU A CD  1 
ATOM   1833 O  OE1 . GLU A 1 228 ? -2.238  -28.491 -18.625 1    59.04  ? 224 GLU A OE1 1 
ATOM   1834 O  OE2 . GLU A 1 228 ? -0.318  -27.483 -18.232 1    63.22  ? 224 GLU A OE2 1 
ATOM   1835 N  N   . VAL A 1 229 ? -2.187  -33.789 -17.58  1    47.13  ? 225 VAL A N   1 
ATOM   1836 C  CA  . VAL A 1 229 ? -3.249  -34.787 -17.501 1    48.96  ? 225 VAL A CA  1 
ATOM   1837 C  C   . VAL A 1 229 ? -3.875  -34.823 -16.106 1    49.33  ? 225 VAL A C   1 
ATOM   1838 O  O   . VAL A 1 229 ? -5.082  -34.842 -15.993 1    52.36  ? 225 VAL A O   1 
ATOM   1839 C  CB  . VAL A 1 229 ? -2.792  -36.204 -17.882 1    50.05  ? 225 VAL A CB  1 
ATOM   1840 C  CG1 . VAL A 1 229 ? -3.961  -37.18  -17.795 1    47.49  ? 225 VAL A CG1 1 
ATOM   1841 C  CG2 . VAL A 1 229 ? -2.135  -36.226 -19.261 1    51.04  ? 225 VAL A CG2 1 
ATOM   1842 N  N   . VAL A 1 230 ? -3.072  -34.909 -15.039 1    44.77  ? 226 VAL A N   1 
ATOM   1843 C  CA  . VAL A 1 230 ? -3.669  -34.983 -13.724 1    45.44  ? 226 VAL A CA  1 
ATOM   1844 C  C   . VAL A 1 230 ? -4.196  -33.596 -13.337 1    47.37  ? 226 VAL A C   1 
ATOM   1845 O  O   . VAL A 1 230 ? -5.189  -33.47  -12.609 1    51.59  ? 226 VAL A O   1 
ATOM   1846 C  CB  . VAL A 1 230 ? -2.663  -35.547 -12.708 1    47.75  ? 226 VAL A CB  1 
ATOM   1847 C  CG1 . VAL A 1 230 ? -1.443  -34.663 -12.649 1    59.23  ? 226 VAL A CG1 1 
ATOM   1848 C  CG2 . VAL A 1 230 ? -3.243  -35.662 -11.305 1    51.06  ? 226 VAL A CG2 1 
ATOM   1849 N  N   . TRP A 1 231 ? -3.548  -32.537 -13.818 1    45.77  ? 227 TRP A N   1 
ATOM   1850 C  CA  . TRP A 1 231 ? -3.895  -31.2   -13.362 1    50.64  ? 227 TRP A CA  1 
ATOM   1851 C  C   . TRP A 1 231 ? -3.739  -30.2   -14.513 1    51.3   ? 227 TRP A C   1 
ATOM   1852 O  O   . TRP A 1 231 ? -2.677  -29.615 -14.703 1    54.25  ? 227 TRP A O   1 
ATOM   1853 C  CB  . TRP A 1 231 ? -3.063  -30.834 -12.12  1    44.4   ? 227 TRP A CB  1 
ATOM   1854 C  CG  . TRP A 1 231 ? -3.38   -29.504 -11.49  1    47.22  ? 227 TRP A CG  1 
ATOM   1855 C  CD1 . TRP A 1 231 ? -4.384  -28.646 -11.822 1    45.38  ? 227 TRP A CD1 1 
ATOM   1856 C  CD2 . TRP A 1 231 ? -2.666  -28.885 -10.397 1    46.4   ? 227 TRP A CD2 1 
ATOM   1857 N  NE1 . TRP A 1 231 ? -4.347  -27.545 -11.012 1    47.34  ? 227 TRP A NE1 1 
ATOM   1858 C  CE2 . TRP A 1 231 ? -3.319  -27.667 -10.123 1    42.63  ? 227 TRP A CE2 1 
ATOM   1859 C  CE3 . TRP A 1 231 ? -1.546  -29.246 -9.636  1    44.29  ? 227 TRP A CE3 1 
ATOM   1860 C  CZ2 . TRP A 1 231 ? -2.893  -26.801 -9.13   1    44.13  ? 227 TRP A CZ2 1 
ATOM   1861 C  CZ3 . TRP A 1 231 ? -1.121  -28.39  -8.654  1    49.49  ? 227 TRP A CZ3 1 
ATOM   1862 C  CH2 . TRP A 1 231 ? -1.797  -27.194 -8.392  1    49.95  ? 227 TRP A CH2 1 
ATOM   1863 N  N   . PRO A 1 232 ? -4.786  -29.98  -15.322 1    52.04  ? 228 PRO A N   1 
ATOM   1864 C  CA  . PRO A 1 232 ? -4.691  -29.021 -16.432 1    54.29  ? 228 PRO A CA  1 
ATOM   1865 C  C   . PRO A 1 232 ? -4.361  -27.626 -15.895 1    51.99  ? 228 PRO A C   1 
ATOM   1866 O  O   . PRO A 1 232 ? -4.956  -27.188 -14.91  1    44.18  ? 228 PRO A O   1 
ATOM   1867 C  CB  . PRO A 1 232 ? -6.065  -29.085 -17.185 1    47.4   ? 228 PRO A CB  1 
ATOM   1868 C  CG  . PRO A 1 232 ? -6.771  -30.292 -16.569 1    51.01  ? 228 PRO A CG  1 
ATOM   1869 C  CD  . PRO A 1 232 ? -6.099  -30.648 -15.216 1    51.97  ? 228 PRO A CD  1 
ATOM   1870 N  N   . GLY A 1 233 ? -3.393  -26.952 -16.55  1    55.39  ? 229 GLY A N   1 
ATOM   1871 C  CA  . GLY A 1 233 ? -2.948  -25.619 -16.157 1    54.93  ? 229 GLY A CA  1 
ATOM   1872 C  C   . GLY A 1 233 ? -1.646  -25.598 -15.35  1    59.27  ? 229 GLY A C   1 
ATOM   1873 O  O   . GLY A 1 233 ? -0.92   -24.61  -15.344 1    66.35  ? 229 GLY A O   1 
ATOM   1874 N  N   . VAL A 1 234 ? -1.327  -26.712 -14.688 1    57.25  ? 230 VAL A N   1 
ATOM   1875 C  CA  . VAL A 1 234 ? -0.256  -26.764 -13.709 1    50.2   ? 230 VAL A CA  1 
ATOM   1876 C  C   . VAL A 1 234 ? 1.025   -26.185 -14.315 1    58.3   ? 230 VAL A C   1 
ATOM   1877 O  O   . VAL A 1 234 ? 1.67    -25.359 -13.66  1    59.67  ? 230 VAL A O   1 
ATOM   1878 C  CB  . VAL A 1 234 ? -0.074  -28.173 -13.115 1    42.65  ? 230 VAL A CB  1 
ATOM   1879 C  CG1 . VAL A 1 234 ? 0.585   -29.121 -14.09  1    39.96  ? 230 VAL A CG1 1 
ATOM   1880 C  CG2 . VAL A 1 234 ? 0.718   -28.162 -11.828 1    39.97  ? 230 VAL A CG2 1 
ATOM   1881 N  N   . THR A 1 235 ? 1.361   -26.588 -15.559 1    54.36  ? 231 THR A N   1 
ATOM   1882 C  CA  . THR A 1 235 ? 2.633   -26.233 -16.177 1    51.17  ? 231 THR A CA  1 
ATOM   1883 C  C   . THR A 1 235 ? 2.657   -24.751 -16.54  1    55.97  ? 231 THR A C   1 
ATOM   1884 O  O   . THR A 1 235 ? 3.725   -24.253 -16.899 1    57.3   ? 231 THR A O   1 
ATOM   1885 C  CB  . THR A 1 235 ? 2.99    -27.056 -17.415 1    50.81  ? 231 THR A CB  1 
ATOM   1886 O  OG1 . THR A 1 235 ? 2.067   -26.662 -18.422 1    54.67  ? 231 THR A OG1 1 
ATOM   1887 C  CG2 . THR A 1 235 ? 3.045   -28.554 -17.18  1    45.32  ? 231 THR A CG2 1 
ATOM   1888 N  N   . SER A 1 236 ? 1.51    -24.06  -16.419 1    55.15  ? 232 SER A N   1 
ATOM   1889 C  CA  . SER A 1 236 ? 1.397   -22.647 -16.765 1    60.37  ? 232 SER A CA  1 
ATOM   1890 C  C   . SER A 1 236 ? 1.433   -21.786 -15.517 1    62.68  ? 232 SER A C   1 
ATOM   1891 O  O   . SER A 1 236 ? 1.337   -20.57  -15.62  1    69.58  ? 232 SER A O   1 
ATOM   1892 C  CB  . SER A 1 236 ? 0.122   -22.35  -17.524 1    65.79  ? 232 SER A CB  1 
ATOM   1893 O  OG  . SER A 1 236 ? 0.323   -22.628 -18.905 1    81.42  ? 232 SER A OG  1 
ATOM   1894 N  N   . MET A 1 237 ? 1.563   -22.422 -14.352 1    63.38  ? 233 MET A N   1 
ATOM   1895 C  CA  . MET A 1 237 ? 1.441   -21.724 -13.084 1    58.22  ? 233 MET A CA  1 
ATOM   1896 C  C   . MET A 1 237 ? 2.685   -20.89  -12.79  1    54.92  ? 233 MET A C   1 
ATOM   1897 O  O   . MET A 1 237 ? 3.796   -21.279 -13.182 1    52.23  ? 233 MET A O   1 
ATOM   1898 C  CB  . MET A 1 237 ? 1.039   -22.703 -11.984 1    55.35  ? 233 MET A CB  1 
ATOM   1899 C  CG  . MET A 1 237 ? -0.445  -22.816 -11.962 1    63.65  ? 233 MET A CG  1 
ATOM   1900 S  SD  . MET A 1 237 ? -1.181  -24.35  -11.41  1    71.62  ? 233 MET A SD  1 
ATOM   1901 C  CE  . MET A 1 237 ? -0.352  -24.486 -9.831  1    104.57 ? 233 MET A CE  1 
ATOM   1902 N  N   . PRO A 1 238 ? 2.517   -19.71  -12.14  1    50.69  ? 234 PRO A N   1 
ATOM   1903 C  CA  . PRO A 1 238 ? 3.6     -18.728 -12.066 1    49.51  ? 234 PRO A CA  1 
ATOM   1904 C  C   . PRO A 1 238 ? 4.934   -19.258 -11.539 1    50.29  ? 234 PRO A C   1 
ATOM   1905 O  O   . PRO A 1 238 ? 5.984   -18.868 -12.06  1    58.68  ? 234 PRO A O   1 
ATOM   1906 C  CB  . PRO A 1 238 ? 3.005   -17.587 -11.205 1    48.7   ? 234 PRO A CB  1 
ATOM   1907 C  CG  . PRO A 1 238 ? 1.505   -17.748 -11.355 1    48.77  ? 234 PRO A CG  1 
ATOM   1908 C  CD  . PRO A 1 238 ? 1.296   -19.262 -11.437 1    47.11  ? 234 PRO A CD  1 
ATOM   1909 N  N   . ASP A 1 239 ? 4.876   -20.178 -10.557 1    46.14  ? 235 ASP A N   1 
ATOM   1910 C  CA  . ASP A 1 239 ? 6.049   -20.744 -9.913  1    47.96  ? 235 ASP A CA  1 
ATOM   1911 C  C   . ASP A 1 239 ? 6.244   -22.211 -10.293 1    51.79  ? 235 ASP A C   1 
ATOM   1912 O  O   . ASP A 1 239 ? 7.007   -22.923 -9.634  1    59.43  ? 235 ASP A O   1 
ATOM   1913 C  CB  . ASP A 1 239 ? 6.08    -20.417 -8.426  1    45.46  ? 235 ASP A CB  1 
ATOM   1914 C  CG  . ASP A 1 239 ? 6.078   -18.924 -8.132  1    48.66  ? 235 ASP A CG  1 
ATOM   1915 O  OD1 . ASP A 1 239 ? 6.579   -18.17  -8.963  1    54.6   ? 235 ASP A OD1 1 
ATOM   1916 O  OD2 . ASP A 1 239 ? 5.483   -18.501 -7.14   1    54.72  ? 235 ASP A OD2 1 
ATOM   1917 N  N   . TYR A 1 240 ? 5.586   -22.651 -11.37  1    50.11  ? 236 TYR A N   1 
ATOM   1918 C  CA  . TYR A 1 240 ? 5.874   -23.934 -11.991 1    47.92  ? 236 TYR A CA  1 
ATOM   1919 C  C   . TYR A 1 240 ? 7.089   -23.738 -12.886 1    49.91  ? 236 TYR A C   1 
ATOM   1920 O  O   . TYR A 1 240 ? 7.135   -22.806 -13.694 1    52.06  ? 236 TYR A O   1 
ATOM   1921 C  CB  . TYR A 1 240 ? 4.724   -24.509 -12.836 1    50.04  ? 236 TYR A CB  1 
ATOM   1922 C  CG  . TYR A 1 240 ? 5.067   -25.85  -13.473 1    54.06  ? 236 TYR A CG  1 
ATOM   1923 C  CD1 . TYR A 1 240 ? 4.929   -27.048 -12.775 1    55.68  ? 236 TYR A CD1 1 
ATOM   1924 C  CD2 . TYR A 1 240 ? 5.559   -25.92  -14.769 1    57     ? 236 TYR A CD2 1 
ATOM   1925 C  CE1 . TYR A 1 240 ? 5.272   -28.268 -13.344 1    57.39  ? 236 TYR A CE1 1 
ATOM   1926 C  CE2 . TYR A 1 240 ? 5.915   -27.131 -15.348 1    58.8   ? 236 TYR A CE2 1 
ATOM   1927 C  CZ  . TYR A 1 240 ? 5.781   -28.314 -14.636 1    64.61  ? 236 TYR A CZ  1 
ATOM   1928 O  OH  . TYR A 1 240 ? 6.137   -29.509 -15.23  1    63.34  ? 236 TYR A OH  1 
ATOM   1929 N  N   . LYS A 1 241 ? 8.041   -24.655 -12.751 1    47.19  ? 237 LYS A N   1 
ATOM   1930 C  CA  . LYS A 1 241 ? 9.237   -24.677 -13.556 1    47.94  ? 237 LYS A CA  1 
ATOM   1931 C  C   . LYS A 1 241 ? 9.289   -26.021 -14.282 1    47.6   ? 237 LYS A C   1 
ATOM   1932 O  O   . LYS A 1 241 ? 9.098   -27.06  -13.663 1    45.11  ? 237 LYS A O   1 
ATOM   1933 C  CB  . LYS A 1 241 ? 10.426  -24.448 -12.613 1    50.21  ? 237 LYS A CB  1 
ATOM   1934 C  CG  . LYS A 1 241 ? 10.698  -23.008 -12.185 1    58.63  ? 237 LYS A CG  1 
ATOM   1935 C  CD  . LYS A 1 241 ? 11.192  -22.867 -10.744 1    75.44  ? 237 LYS A CD  1 
ATOM   1936 C  CE  . LYS A 1 241 ? 12.354  -23.744 -10.351 1    85.38  ? 237 LYS A CE  1 
ATOM   1937 N  NZ  . LYS A 1 241 ? 13.492  -23.368 -11.183 1    102.66 ? 237 LYS A NZ  1 
ATOM   1938 N  N   . PRO A 1 242 ? 9.528   -26.036 -15.619 1    47.82  ? 238 PRO A N   1 
ATOM   1939 C  CA  . PRO A 1 242 ? 9.766   -27.27  -16.371 1    48.98  ? 238 PRO A CA  1 
ATOM   1940 C  C   . PRO A 1 242 ? 10.869  -28.213 -15.861 1    51.32  ? 238 PRO A C   1 
ATOM   1941 O  O   . PRO A 1 242 ? 10.798  -29.43  -16.07  1    50.03  ? 238 PRO A O   1 
ATOM   1942 C  CB  . PRO A 1 242 ? 10.052  -26.778 -17.825 1    48.94  ? 238 PRO A CB  1 
ATOM   1943 C  CG  . PRO A 1 242 ? 10.267  -25.299 -17.742 1    47.85  ? 238 PRO A CG  1 
ATOM   1944 C  CD  . PRO A 1 242 ? 9.534   -24.853 -16.485 1    47.31  ? 238 PRO A CD  1 
ATOM   1945 N  N   . SER A 1 243 ? 11.872  -27.632 -15.183 1    50.3   ? 239 SER A N   1 
ATOM   1946 C  CA  . SER A 1 243 ? 13.023  -28.319 -14.599 1    48.95  ? 239 SER A CA  1 
ATOM   1947 C  C   . SER A 1 243 ? 12.629  -29.204 -13.401 1    44.84  ? 239 SER A C   1 
ATOM   1948 O  O   . SER A 1 243 ? 13.468  -29.934 -12.895 1    41.81  ? 239 SER A O   1 
ATOM   1949 C  CB  . SER A 1 243 ? 14.058  -27.274 -14.163 1    49.06  ? 239 SER A CB  1 
ATOM   1950 O  OG  . SER A 1 243 ? 13.58   -26.516 -13.033 1    54.88  ? 239 SER A OG  1 
ATOM   1951 N  N   . PHE A 1 244 ? 11.398  -29.066 -12.888 1    42.2   ? 240 PHE A N   1 
ATOM   1952 C  CA  . PHE A 1 244 ? 10.935  -29.873 -11.771 1    43.26  ? 240 PHE A CA  1 
ATOM   1953 C  C   . PHE A 1 244 ? 11.187  -31.362 -11.998 1    43.56  ? 240 PHE A C   1 
ATOM   1954 O  O   . PHE A 1 244 ? 10.864  -31.915 -13.043 1    43.61  ? 240 PHE A O   1 
ATOM   1955 C  CB  . PHE A 1 244 ? 9.447   -29.671 -11.53  1    39.5   ? 240 PHE A CB  1 
ATOM   1956 C  CG  . PHE A 1 244 ? 9.046   -28.435 -10.734 1    43.11  ? 240 PHE A CG  1 
ATOM   1957 C  CD1 . PHE A 1 244 ? 9.958   -27.729 -9.965  1    45.64  ? 240 PHE A CD1 1 
ATOM   1958 C  CD2 . PHE A 1 244 ? 7.717   -28.013 -10.734 1    43.69  ? 240 PHE A CD2 1 
ATOM   1959 C  CE1 . PHE A 1 244 ? 9.529   -26.628 -9.234  1    46.36  ? 240 PHE A CE1 1 
ATOM   1960 C  CE2 . PHE A 1 244 ? 7.309   -26.91  -10.012 1    42.52  ? 240 PHE A CE2 1 
ATOM   1961 C  CZ  . PHE A 1 244 ? 8.216   -26.228 -9.255  1    42.11  ? 240 PHE A CZ  1 
ATOM   1962 N  N   . PRO A 1 245 ? 11.757  -32.09  -11.021 1    46.8   ? 241 PRO A N   1 
ATOM   1963 C  CA  . PRO A 1 245 ? 11.927  -33.537 -11.176 1    51.63  ? 241 PRO A CA  1 
ATOM   1964 C  C   . PRO A 1 245 ? 10.561  -34.181 -11.382 1    48.98  ? 241 PRO A C   1 
ATOM   1965 O  O   . PRO A 1 245 ? 9.562   -33.731 -10.822 1    44.25  ? 241 PRO A O   1 
ATOM   1966 C  CB  . PRO A 1 245 ? 12.62   -33.975 -9.862  1    50.61  ? 241 PRO A CB  1 
ATOM   1967 C  CG  . PRO A 1 245 ? 13.272  -32.689 -9.36   1    49.57  ? 241 PRO A CG  1 
ATOM   1968 C  CD  . PRO A 1 245 ? 12.261  -31.604 -9.727  1    48.5   ? 241 PRO A CD  1 
ATOM   1969 N  N   . LYS A 1 246 ? 10.533  -35.238 -12.191 1    52.05  ? 242 LYS A N   1 
ATOM   1970 C  CA  . LYS A 1 246 ? 9.273   -35.899 -12.512 1    54.85  ? 242 LYS A CA  1 
ATOM   1971 C  C   . LYS A 1 246 ? 9.199   -37.217 -11.749 1    49.98  ? 242 LYS A C   1 
ATOM   1972 O  O   . LYS A 1 246 ? 9.606   -38.226 -12.287 1    58.94  ? 242 LYS A O   1 
ATOM   1973 C  CB  . LYS A 1 246 ? 9.109   -36.067 -14.038 1    53.65  ? 242 LYS A CB  1 
ATOM   1974 C  CG  . LYS A 1 246 ? 8.656   -34.777 -14.734 1    64.53  ? 242 LYS A CG  1 
ATOM   1975 C  CD  . LYS A 1 246 ? 8.512   -34.912 -16.248 1    79.13  ? 242 LYS A CD  1 
ATOM   1976 C  CE  . LYS A 1 246 ? 7.813   -33.747 -16.881 1    79.34  ? 242 LYS A CE  1 
ATOM   1977 N  NZ  . LYS A 1 246 ? 8.718   -32.632 -17.133 1    85.15  ? 242 LYS A NZ  1 
ATOM   1978 N  N   . TRP A 1 247 ? 8.647   -37.193 -10.53  1    43.42  ? 243 TRP A N   1 
ATOM   1979 C  CA  . TRP A 1 247 ? 8.497   -38.372 -9.697  1    40.59  ? 243 TRP A CA  1 
ATOM   1980 C  C   . TRP A 1 247 ? 7.229   -39.141 -10.076 1    39.93  ? 243 TRP A C   1 
ATOM   1981 O  O   . TRP A 1 247 ? 6.2     -38.547 -10.342 1    39.85  ? 243 TRP A O   1 
ATOM   1982 C  CB  . TRP A 1 247 ? 8.486   -37.952 -8.218  1    36.53  ? 243 TRP A CB  1 
ATOM   1983 C  CG  . TRP A 1 247 ? 9.836   -37.546 -7.678  1    40.5   ? 243 TRP A CG  1 
ATOM   1984 C  CD1 . TRP A 1 247 ? 10.875  -38.378 -7.349  1    39.03  ? 243 TRP A CD1 1 
ATOM   1985 C  CD2 . TRP A 1 247 ? 10.288  -36.208 -7.358  1    39.89  ? 243 TRP A CD2 1 
ATOM   1986 N  NE1 . TRP A 1 247 ? 11.937  -37.658 -6.874  1    41.02  ? 243 TRP A NE1 1 
ATOM   1987 C  CE2 . TRP A 1 247 ? 11.605  -36.327 -6.859  1    41.28  ? 243 TRP A CE2 1 
ATOM   1988 C  CE3 . TRP A 1 247 ? 9.715   -34.932 -7.44   1    39.31  ? 243 TRP A CE3 1 
ATOM   1989 C  CZ2 . TRP A 1 247 ? 12.35   -35.216 -6.457  1    42.33  ? 243 TRP A CZ2 1 
ATOM   1990 C  CZ3 . TRP A 1 247 ? 10.444  -33.838 -7.008  1    40.55  ? 243 TRP A CZ3 1 
ATOM   1991 C  CH2 . TRP A 1 247 ? 11.752  -33.977 -6.534  1    40.91  ? 243 TRP A CH2 1 
ATOM   1992 N  N   . ALA A 1 248 ? 7.278   -40.473 -10.049 1    42.44  ? 244 ALA A N   1 
ATOM   1993 C  CA  . ALA A 1 248 ? 6.082   -41.28  -10.244 1    42.72  ? 244 ALA A CA  1 
ATOM   1994 C  C   . ALA A 1 248 ? 5.258   -41.316 -8.961  1    44.06  ? 244 ALA A C   1 
ATOM   1995 O  O   . ALA A 1 248 ? 5.774   -41.296 -7.842  1    49.74  ? 244 ALA A O   1 
ATOM   1996 C  CB  . ALA A 1 248 ? 6.437   -42.668 -10.718 1    42.41  ? 244 ALA A CB  1 
ATOM   1997 N  N   . ARG A 1 249 ? 3.942   -41.289 -9.152  1    46.72  ? 245 ARG A N   1 
ATOM   1998 C  CA  . ARG A 1 249 ? 2.971   -41.41  -8.078  1    46.17  ? 245 ARG A CA  1 
ATOM   1999 C  C   . ARG A 1 249 ? 3.121   -42.8   -7.472  1    52.7   ? 245 ARG A C   1 
ATOM   2000 O  O   . ARG A 1 249 ? 3.073   -43.816 -8.167  1    51.86  ? 245 ARG A O   1 
ATOM   2001 C  CB  . ARG A 1 249 ? 1.592   -41.187 -8.696  1    42.35  ? 245 ARG A CB  1 
ATOM   2002 C  CG  . ARG A 1 249 ? 0.45    -41.533 -7.757  1    49.45  ? 245 ARG A CG  1 
ATOM   2003 C  CD  . ARG A 1 249 ? -0.902  -41.045 -8.269  1    47.06  ? 245 ARG A CD  1 
ATOM   2004 N  NE  . ARG A 1 249 ? -1.908  -41.19  -7.213  1    53.64  ? 245 ARG A NE  1 
ATOM   2005 C  CZ  . ARG A 1 249 ? -2.355  -40.196 -6.436  1    58.72  ? 245 ARG A CZ  1 
ATOM   2006 N  NH1 . ARG A 1 249 ? -1.779  -38.986 -6.473  1    47.33  ? 245 ARG A NH1 1 
ATOM   2007 N  NH2 . ARG A 1 249 ? -3.364  -40.446 -5.602  1    58.5   ? 245 ARG A NH2 1 
ATOM   2008 N  N   . GLN A 1 250 ? 3.388   -42.855 -6.169  1    65.12  ? 246 GLN A N   1 
ATOM   2009 C  CA  . GLN A 1 250 ? 3.438   -44.159 -5.525  1    64.41  ? 246 GLN A CA  1 
ATOM   2010 C  C   . GLN A 1 250 ? 1.995   -44.561 -5.223  1    66.02  ? 246 GLN A C   1 
ATOM   2011 O  O   . GLN A 1 250 ? 1.116   -43.687 -5.09   1    65.65  ? 246 GLN A O   1 
ATOM   2012 C  CB  . GLN A 1 250 ? 4.352   -44.143 -4.298  1    58.36  ? 246 GLN A CB  1 
ATOM   2013 C  CG  . GLN A 1 250 ? 3.755   -43.42  -3.1    1    54.48  ? 246 GLN A CG  1 
ATOM   2014 C  CD  . GLN A 1 250 ? 4.798   -43.247 -2.022  1    62.79  ? 246 GLN A CD  1 
ATOM   2015 O  OE1 . GLN A 1 250 ? 5.035   -42.14  -1.538  1    65.86  ? 246 GLN A OE1 1 
ATOM   2016 N  NE2 . GLN A 1 250 ? 5.478   -44.332 -1.68   1    69.72  ? 246 GLN A NE2 1 
ATOM   2017 N  N   . ASP A 1 251 ? 1.769   -45.882 -5.19   1    61.62  ? 247 ASP A N   1 
ATOM   2018 C  CA  . ASP A 1 251 ? 0.485   -46.453 -4.807  1    64.93  ? 247 ASP A CA  1 
ATOM   2019 C  C   . ASP A 1 251 ? 0.091   -45.909 -3.429  1    55.08  ? 247 ASP A C   1 
ATOM   2020 O  O   . ASP A 1 251 ? 0.912   -45.806 -2.531  1    57.77  ? 247 ASP A O   1 
ATOM   2021 C  CB  . ASP A 1 251 ? 0.496   -47.966 -5.023  1    72.3   ? 247 ASP A CB  1 
ATOM   2022 C  CG  . ASP A 1 251 ? -0.812  -48.708 -4.757  1    98.02  ? 247 ASP A CG  1 
ATOM   2023 O  OD1 . ASP A 1 251 ? -1.82   -48.044 -4.399  1    100.95 ? 247 ASP A OD1 1 
ATOM   2024 O  OD2 . ASP A 1 251 ? -0.83   -49.958 -4.935  1    118.34 ? 247 ASP A OD2 1 
ATOM   2025 N  N   . PHE A 1 252 ? -1.184  -45.584 -3.255  1    55.46  ? 248 PHE A N   1 
ATOM   2026 C  CA  . PHE A 1 252 ? -1.669  -44.808 -2.122  1    50.22  ? 248 PHE A CA  1 
ATOM   2027 C  C   . PHE A 1 252 ? -1.698  -45.617 -0.814  1    49.92  ? 248 PHE A C   1 
ATOM   2028 O  O   . PHE A 1 252 ? -1.8    -45.052 0.273   1    58.49  ? 248 PHE A O   1 
ATOM   2029 C  CB  . PHE A 1 252 ? -3.061  -44.3   -2.531  1    53.51  ? 248 PHE A CB  1 
ATOM   2030 C  CG  . PHE A 1 252 ? -3.306  -42.919 -1.948  1    51.55  ? 248 PHE A CG  1 
ATOM   2031 C  CD1 . PHE A 1 252 ? -2.82   -41.798 -2.611  1    52.39  ? 248 PHE A CD1 1 
ATOM   2032 C  CD2 . PHE A 1 252 ? -3.941  -42.735 -0.739  1    48.1   ? 248 PHE A CD2 1 
ATOM   2033 C  CE1 . PHE A 1 252 ? -2.968  -40.524 -2.104  1    40.56  ? 248 PHE A CE1 1 
ATOM   2034 C  CE2 . PHE A 1 252 ? -4.083  -41.443 -0.25   1    47.75  ? 248 PHE A CE2 1 
ATOM   2035 C  CZ  . PHE A 1 252 ? -3.609  -40.348 -0.943  1    39.38  ? 248 PHE A CZ  1 
ATOM   2036 N  N   . SER A 1 253 ? -1.677  -46.945 -0.928  1    47.89  ? 249 SER A N   1 
ATOM   2037 C  CA  . SER A 1 253 ? -1.617  -47.861 0.192   1    44.27  ? 249 SER A CA  1 
ATOM   2038 C  C   . SER A 1 253 ? -0.255  -47.801 0.875   1    46.41  ? 249 SER A C   1 
ATOM   2039 O  O   . SER A 1 253 ? -0.057  -48.39  1.945   1    47     ? 249 SER A O   1 
ATOM   2040 C  CB  . SER A 1 253 ? -1.927  -49.285 -0.281  1    44.62  ? 249 SER A CB  1 
ATOM   2041 O  OG  . SER A 1 253 ? -0.849  -49.883 -0.998  1    44.19  ? 249 SER A OG  1 
ATOM   2042 N  N   . LYS A 1 254 ? 0.695   -47.128 0.219   1    50.56  ? 250 LYS A N   1 
ATOM   2043 C  CA  . LYS A 1 254 ? 2.057   -46.992 0.724   1    51.88  ? 250 LYS A CA  1 
ATOM   2044 C  C   . LYS A 1 254 ? 2.199   -45.66  1.452   1    51.85  ? 250 LYS A C   1 
ATOM   2045 O  O   . LYS A 1 254 ? 3.061   -45.53  2.306   1    61.96  ? 250 LYS A O   1 
ATOM   2046 C  CB  . LYS A 1 254 ? 3.1     -47.149 -0.386  1    47.69  ? 250 LYS A CB  1 
ATOM   2047 C  CG  . LYS A 1 254 ? 3.078   -48.537 -1.022  1    47.41  ? 250 LYS A CG  1 
ATOM   2048 C  CD  . LYS A 1 254 ? 3.541   -49.637 -0.07   1    51.15  ? 250 LYS A CD  1 
ATOM   2049 C  CE  . LYS A 1 254 ? 3.533   -51.03  -0.614  1    53.19  ? 250 LYS A CE  1 
ATOM   2050 N  NZ  . LYS A 1 254 ? 2.19    -51.617 -0.548  1    61.12  ? 250 LYS A NZ  1 
ATOM   2051 N  N   . VAL A 1 255 ? 1.329   -44.698 1.138   1    44.26  ? 251 VAL A N   1 
ATOM   2052 C  CA  . VAL A 1 255 ? 1.398   -43.393 1.764   1    42.82  ? 251 VAL A CA  1 
ATOM   2053 C  C   . VAL A 1 255 ? 0.955   -43.483 3.219   1    43.87  ? 251 VAL A C   1 
ATOM   2054 O  O   . VAL A 1 255 ? 1.579   -42.862 4.069   1    46.04  ? 251 VAL A O   1 
ATOM   2055 C  CB  . VAL A 1 255 ? 0.54    -42.363 1.038   1    38.83  ? 251 VAL A CB  1 
ATOM   2056 C  CG1 . VAL A 1 255 ? 0.55    -41.039 1.799   1    38.18  ? 251 VAL A CG1 1 
ATOM   2057 C  CG2 . VAL A 1 255 ? 0.997   -42.211 -0.412  1    36.88  ? 251 VAL A CG2 1 
ATOM   2058 N  N   . VAL A 1 256 ? -0.123  -44.23  3.49    1    43.65  ? 252 VAL A N   1 
ATOM   2059 C  CA  . VAL A 1 256 ? -0.597  -44.431 4.853   1    40.99  ? 252 VAL A CA  1 
ATOM   2060 C  C   . VAL A 1 256 ? -0.954  -45.897 5       1    41.19  ? 252 VAL A C   1 
ATOM   2061 O  O   . VAL A 1 256 ? -2.125  -46.237 5.019   1    44.07  ? 252 VAL A O   1 
ATOM   2062 C  CB  . VAL A 1 256 ? -1.776  -43.502 5.237   1    43.46  ? 252 VAL A CB  1 
ATOM   2063 C  CG1 . VAL A 1 256 ? -2.186  -43.629 6.7     1    40.7   ? 252 VAL A CG1 1 
ATOM   2064 C  CG2 . VAL A 1 256 ? -1.448  -42.031 4.943   1    41.2   ? 252 VAL A CG2 1 
ATOM   2065 N  N   . PRO A 1 257 ? 0.046   -46.8   5.119   1    43.68  ? 253 PRO A N   1 
ATOM   2066 C  CA  . PRO A 1 257 ? -0.205  -48.241 5.155   1    43.89  ? 253 PRO A CA  1 
ATOM   2067 C  C   . PRO A 1 257 ? -1.336  -48.743 6.047   1    45.61  ? 253 PRO A C   1 
ATOM   2068 O  O   . PRO A 1 257 ? -2.089  -49.598 5.602   1    50.79  ? 253 PRO A O   1 
ATOM   2069 C  CB  . PRO A 1 257 ? 1.164   -48.813 5.571   1    45.23  ? 253 PRO A CB  1 
ATOM   2070 C  CG  . PRO A 1 257 ? 2.164   -47.801 5.065   1    42.47  ? 253 PRO A CG  1 
ATOM   2071 C  CD  . PRO A 1 257 ? 1.478   -46.477 5.259   1    41.73  ? 253 PRO A CD  1 
ATOM   2072 N  N   . PRO A 1 258 ? -1.53   -48.272 7.306   1    45.55  ? 254 PRO A N   1 
ATOM   2073 C  CA  . PRO A 1 258 ? -2.579  -48.839 8.164   1    48.59  ? 254 PRO A CA  1 
ATOM   2074 C  C   . PRO A 1 258 ? -4.016  -48.549 7.719   1    49.97  ? 254 PRO A C   1 
ATOM   2075 O  O   . PRO A 1 258 ? -4.932  -49.198 8.195   1    55.3   ? 254 PRO A O   1 
ATOM   2076 C  CB  . PRO A 1 258 ? -2.331  -48.273 9.555   1    46.77  ? 254 PRO A CB  1 
ATOM   2077 C  CG  . PRO A 1 258 ? -1.065  -47.452 9.432   1    46.75  ? 254 PRO A CG  1 
ATOM   2078 C  CD  . PRO A 1 258 ? -0.806  -47.182 7.968   1    42.5   ? 254 PRO A CD  1 
ATOM   2079 N  N   . LEU A 1 259 ? -4.199  -47.61  6.784   1    47.01  ? 255 LEU A N   1 
ATOM   2080 C  CA  . LEU A 1 259 ? -5.511  -47.111 6.375   1    46.3   ? 255 LEU A CA  1 
ATOM   2081 C  C   . LEU A 1 259 ? -6.237  -48.099 5.449   1    49.29  ? 255 LEU A C   1 
ATOM   2082 O  O   . LEU A 1 259 ? -5.634  -48.648 4.526   1    46.34  ? 255 LEU A O   1 
ATOM   2083 C  CB  . LEU A 1 259 ? -5.25   -45.798 5.654   1    39.06  ? 255 LEU A CB  1 
ATOM   2084 C  CG  . LEU A 1 259 ? -6.364  -44.764 5.674   1    40.26  ? 255 LEU A CG  1 
ATOM   2085 C  CD1 . LEU A 1 259 ? -6.953  -44.544 7.07    1    39.69  ? 255 LEU A CD1 1 
ATOM   2086 C  CD2 . LEU A 1 259 ? -5.831  -43.463 5.073   1    34.83  ? 255 LEU A CD2 1 
ATOM   2087 N  N   . ASP A 1 260 ? -7.544  -48.291 5.712   1    51.58  ? 256 ASP A N   1 
ATOM   2088 C  CA  . ASP A 1 260 ? -8.451  -49.194 5       1    59.23  ? 256 ASP A CA  1 
ATOM   2089 C  C   . ASP A 1 260 ? -8.775  -48.641 3.601   1    54.15  ? 256 ASP A C   1 
ATOM   2090 O  O   . ASP A 1 260 ? -8.356  -47.549 3.243   1    49.52  ? 256 ASP A O   1 
ATOM   2091 C  CB  . ASP A 1 260 ? -9.701  -49.467 5.836   1    66.62  ? 256 ASP A CB  1 
ATOM   2092 C  CG  . ASP A 1 260 ? -10.441 -48.224 6.345   1    79.69  ? 256 ASP A CG  1 
ATOM   2093 O  OD1 . ASP A 1 260 ? -11.218 -47.614 5.548   1    72.38  ? 256 ASP A OD1 1 
ATOM   2094 O  OD2 . ASP A 1 260 ? -10.205 -47.826 7.53    1    89.13  ? 256 ASP A OD2 1 
ATOM   2095 N  N   . GLU A 1 261 ? -9.562  -49.382 2.812   1    50.69  ? 257 GLU A N   1 
ATOM   2096 C  CA  . GLU A 1 261 ? -9.86   -48.972 1.447   1    52.29  ? 257 GLU A CA  1 
ATOM   2097 C  C   . GLU A 1 261 ? -10.688 -47.678 1.386   1    53.6   ? 257 GLU A C   1 
ATOM   2098 O  O   . GLU A 1 261 ? -10.438 -46.829 0.524   1    49.68  ? 257 GLU A O   1 
ATOM   2099 C  CB  . GLU A 1 261 ? -10.583 -50.139 0.792   1    56.15  ? 257 GLU A CB  1 
ATOM   2100 C  CG  . GLU A 1 261 ? -10.885 -49.918 -0.69   1    66.07  ? 257 GLU A CG  1 
ATOM   2101 C  CD  . GLU A 1 261 ? -11.549 -51.143 -1.298  1    73.29  ? 257 GLU A CD  1 
ATOM   2102 O  OE1 . GLU A 1 261 ? -12.716 -51.025 -1.71   1    78.76  ? 257 GLU A OE1 1 
ATOM   2103 O  OE2 . GLU A 1 261 ? -10.917 -52.22  -1.325  1    79.2   ? 257 GLU A OE2 1 
ATOM   2104 N  N   . ASP A 1 262 ? -11.691 -47.56  2.274   1    48.45  ? 258 ASP A N   1 
ATOM   2105 C  CA  . ASP A 1 262 ? -12.527 -46.377 2.398   1    45.29  ? 258 ASP A CA  1 
ATOM   2106 C  C   . ASP A 1 262 ? -11.673 -45.191 2.829   1    43.3   ? 258 ASP A C   1 
ATOM   2107 O  O   . ASP A 1 262 ? -11.732 -44.128 2.226   1    41.54  ? 258 ASP A O   1 
ATOM   2108 C  CB  . ASP A 1 262 ? -13.671 -46.613 3.375   1    47.37  ? 258 ASP A CB  1 
ATOM   2109 C  CG  . ASP A 1 262 ? -14.837 -47.446 2.856   1    51.39  ? 258 ASP A CG  1 
ATOM   2110 O  OD1 . ASP A 1 262 ? -14.973 -47.547 1.622   1    50.31  ? 258 ASP A OD1 1 
ATOM   2111 O  OD2 . ASP A 1 262 ? -15.584 -47.995 3.696   1    54.32  ? 258 ASP A OD2 1 
ATOM   2112 N  N   . GLY A 1 263 ? -10.876 -45.368 3.883   1    44.99  ? 259 GLY A N   1 
ATOM   2113 C  CA  . GLY A 1 263 ? -9.958  -44.323 4.318   1    44.36  ? 259 GLY A CA  1 
ATOM   2114 C  C   . GLY A 1 263 ? -9.078  -43.81  3.177   1    41.97  ? 259 GLY A C   1 
ATOM   2115 O  O   . GLY A 1 263 ? -8.979  -42.601 2.977   1    39.61  ? 259 GLY A O   1 
ATOM   2116 N  N   . ARG A 1 264 ? -8.482  -44.737 2.412   1    38.77  ? 260 ARG A N   1 
ATOM   2117 C  CA  . ARG A 1 264 ? -7.577  -44.384 1.331   1    39.96  ? 260 ARG A CA  1 
ATOM   2118 C  C   . ARG A 1 264 ? -8.315  -43.573 0.274   1    38.74  ? 260 ARG A C   1 
ATOM   2119 O  O   . ARG A 1 264 ? -7.802  -42.602 -0.252  1    40.81  ? 260 ARG A O   1 
ATOM   2120 C  CB  . ARG A 1 264 ? -6.926  -45.6   0.658   1    41.68  ? 260 ARG A CB  1 
ATOM   2121 C  CG  . ARG A 1 264 ? -5.877  -46.219 1.571   1    47.31  ? 260 ARG A CG  1 
ATOM   2122 C  CD  . ARG A 1 264 ? -4.862  -47.1   0.862   1    51.88  ? 260 ARG A CD  1 
ATOM   2123 N  NE  . ARG A 1 264 ? -5.518  -48.104 0.023   1    50.3   ? 260 ARG A NE  1 
ATOM   2124 C  CZ  . ARG A 1 264 ? -6.038  -49.231 0.47    1    47.24  ? 260 ARG A CZ  1 
ATOM   2125 N  NH1 . ARG A 1 264 ? -5.865  -49.601 1.732   1    43.97  ? 260 ARG A NH1 1 
ATOM   2126 N  NH2 . ARG A 1 264 ? -6.711  -49.99  -0.377  1    43.92  ? 260 ARG A NH2 1 
ATOM   2127 N  N   . SER A 1 265 ? -9.517  -44.018 -0.048  1    42.21  ? 261 SER A N   1 
ATOM   2128 C  CA  . SER A 1 265 ? -10.36  -43.352 -1.019  1    41.58  ? 261 SER A CA  1 
ATOM   2129 C  C   . SER A 1 265 ? -10.61  -41.892 -0.606  1    41.68  ? 261 SER A C   1 
ATOM   2130 O  O   . SER A 1 265 ? -10.5   -40.98  -1.438  1    37.92  ? 261 SER A O   1 
ATOM   2131 C  CB  . SER A 1 265 ? -11.631 -44.162 -1.211  1    38.36  ? 261 SER A CB  1 
ATOM   2132 O  OG  . SER A 1 265 ? -12.635 -43.395 -1.858  1    46     ? 261 SER A OG  1 
ATOM   2133 N  N   . LEU A 1 266 ? -10.989 -41.685 0.668   1    35.46  ? 262 LEU A N   1 
ATOM   2134 C  CA  . LEU A 1 266 ? -11.352 -40.355 1.085   1    36.91  ? 262 LEU A CA  1 
ATOM   2135 C  C   . LEU A 1 266 ? -10.098 -39.473 1.051   1    43.47  ? 262 LEU A C   1 
ATOM   2136 O  O   . LEU A 1 266 ? -10.134 -38.348 0.524   1    47.06  ? 262 LEU A O   1 
ATOM   2137 C  CB  . LEU A 1 266 ? -12.021 -40.423 2.456   1    36.29  ? 262 LEU A CB  1 
ATOM   2138 C  CG  . LEU A 1 266 ? -12.163 -39.087 3.208   1    35.95  ? 262 LEU A CG  1 
ATOM   2139 C  CD1 . LEU A 1 266 ? -12.87  -37.999 2.406   1    31.47  ? 262 LEU A CD1 1 
ATOM   2140 C  CD2 . LEU A 1 266 ? -12.88  -39.323 4.511   1    33.08  ? 262 LEU A CD2 1 
ATOM   2141 N  N   . LEU A 1 267 ? -8.977  -40.013 1.551   1    42.46  ? 263 LEU A N   1 
ATOM   2142 C  CA  . LEU A 1 267 ? -7.732  -39.268 1.637   1    37.88  ? 263 LEU A CA  1 
ATOM   2143 C  C   . LEU A 1 267 ? -7.246  -38.866 0.252   1    40.26  ? 263 LEU A C   1 
ATOM   2144 O  O   . LEU A 1 267 ? -6.826  -37.723 0.071   1    46.98  ? 263 LEU A O   1 
ATOM   2145 C  CB  . LEU A 1 267 ? -6.657  -40.04  2.38    1    34.93  ? 263 LEU A CB  1 
ATOM   2146 C  CG  . LEU A 1 267 ? -5.335  -39.283 2.531   1    34.28  ? 263 LEU A CG  1 
ATOM   2147 C  CD1 . LEU A 1 267 ? -5.462  -38.073 3.461   1    30.84  ? 263 LEU A CD1 1 
ATOM   2148 C  CD2 . LEU A 1 267 ? -4.227  -40.244 2.995   1    34.25  ? 263 LEU A CD2 1 
ATOM   2149 N  N   . SER A 1 268 ? -7.301  -39.796 -0.715  1    37.28  ? 264 SER A N   1 
ATOM   2150 C  CA  . SER A 1 268 ? -6.931  -39.463 -2.085  1    41.31  ? 264 SER A CA  1 
ATOM   2151 C  C   . SER A 1 268 ? -7.787  -38.336 -2.668  1    42.26  ? 264 SER A C   1 
ATOM   2152 O  O   . SER A 1 268 ? -7.301  -37.561 -3.494  1    52.41  ? 264 SER A O   1 
ATOM   2153 C  CB  . SER A 1 268 ? -6.891  -40.645 -3.007  1    41.03  ? 264 SER A CB  1 
ATOM   2154 O  OG  . SER A 1 268 ? -8.171  -41.233 -3.076  1    51.03  ? 264 SER A OG  1 
ATOM   2155 N  N   . GLN A 1 269 ? -9.05   -38.24  -2.256  1    38.68  ? 265 GLN A N   1 
ATOM   2156 C  CA  . GLN A 1 269 ? -9.907  -37.22  -2.825  1    39.61  ? 265 GLN A CA  1 
ATOM   2157 C  C   . GLN A 1 269 ? -9.65   -35.884 -2.139  1    40.88  ? 265 GLN A C   1 
ATOM   2158 O  O   . GLN A 1 269 ? -9.869  -34.832 -2.732  1    40.49  ? 265 GLN A O   1 
ATOM   2159 C  CB  . GLN A 1 269 ? -11.364 -37.645 -2.765  1    41.13  ? 265 GLN A CB  1 
ATOM   2160 C  CG  . GLN A 1 269 ? -11.631 -38.859 -3.657  1    45.5   ? 265 GLN A CG  1 
ATOM   2161 C  CD  . GLN A 1 269 ? -13.029 -39.412 -3.491  1    46.48  ? 265 GLN A CD  1 
ATOM   2162 O  OE1 . GLN A 1 269 ? -13.237 -40.515 -2.967  1    48.06  ? 265 GLN A OE1 1 
ATOM   2163 N  NE2 . GLN A 1 269 ? -14.005 -38.604 -3.878  1    47.67  ? 265 GLN A NE2 1 
ATOM   2164 N  N   . MET A 1 270 ? -9.165  -35.932 -0.891  1    37.84  ? 266 MET A N   1 
ATOM   2165 C  CA  . MET A 1 270 ? -8.81   -34.704 -0.203  1    38.51  ? 266 MET A CA  1 
ATOM   2166 C  C   . MET A 1 270 ? -7.483  -34.135 -0.721  1    45.32  ? 266 MET A C   1 
ATOM   2167 O  O   . MET A 1 270 ? -7.29   -32.909 -0.676  1    53.07  ? 266 MET A O   1 
ATOM   2168 C  CB  . MET A 1 270 ? -8.771  -34.915 1.312   1    35.45  ? 266 MET A CB  1 
ATOM   2169 C  CG  . MET A 1 270 ? -10.106 -35.284 1.841   1    33.11  ? 266 MET A CG  1 
ATOM   2170 S  SD  . MET A 1 270 ? -10.085 -35.642 3.604   1    38.98  ? 266 MET A SD  1 
ATOM   2171 C  CE  . MET A 1 270 ? -10.196 -33.996 4.343   1    30.7   ? 266 MET A CE  1 
ATOM   2172 N  N   . LEU A 1 271 ? -6.592  -35.021 -1.211  1    40.99  ? 267 LEU A N   1 
ATOM   2173 C  CA  . LEU A 1 271 ? -5.255  -34.651 -1.649  1    40.53  ? 267 LEU A CA  1 
ATOM   2174 C  C   . LEU A 1 271 ? -5.141  -34.642 -3.179  1    39.33  ? 267 LEU A C   1 
ATOM   2175 O  O   . LEU A 1 271 ? -4.055  -34.74  -3.736  1    38.73  ? 267 LEU A O   1 
ATOM   2176 C  CB  . LEU A 1 271 ? -4.237  -35.592 -1      1    36.86  ? 267 LEU A CB  1 
ATOM   2177 C  CG  . LEU A 1 271 ? -4.163  -35.531 0.53    1    40.59  ? 267 LEU A CG  1 
ATOM   2178 C  CD1 . LEU A 1 271 ? -3.092  -36.466 1.078   1    39.57  ? 267 LEU A CD1 1 
ATOM   2179 C  CD2 . LEU A 1 271 ? -3.954  -34.126 1.093   1    33.34  ? 267 LEU A CD2 1 
ATOM   2180 N  N   . HIS A 1 272 ? -6.257  -34.473 -3.87   1    38.51  ? 268 HIS A N   1 
ATOM   2181 C  CA  . HIS A 1 272 ? -6.221  -34.377 -5.322  1    44.1   ? 268 HIS A CA  1 
ATOM   2182 C  C   . HIS A 1 272 ? -5.511  -33.075 -5.7    1    45.1   ? 268 HIS A C   1 
ATOM   2183 O  O   . HIS A 1 272 ? -5.718  -32.031 -5.043  1    40.18  ? 268 HIS A O   1 
ATOM   2184 C  CB  . HIS A 1 272 ? -7.654  -34.464 -5.843  1    42.34  ? 268 HIS A CB  1 
ATOM   2185 C  CG  . HIS A 1 272 ? -7.838  -34.964 -7.22   1    57.33  ? 268 HIS A CG  1 
ATOM   2186 N  ND1 . HIS A 1 272 ? -7.467  -34.236 -8.34   1    70.12  ? 268 HIS A ND1 1 
ATOM   2187 C  CD2 . HIS A 1 272 ? -8.403  -36.101 -7.65   1    56.77  ? 268 HIS A CD2 1 
ATOM   2188 C  CE1 . HIS A 1 272 ? -7.8    -34.917 -9.424  1    66.33  ? 268 HIS A CE1 1 
ATOM   2189 N  NE2 . HIS A 1 272 ? -8.381  -36.041 -9.03   1    67.14  ? 268 HIS A NE2 1 
ATOM   2190 N  N   . TYR A 1 273 ? -4.671  -33.159 -6.745  1    41.94  ? 269 TYR A N   1 
ATOM   2191 C  CA  . TYR A 1 273 ? -3.892  -32.015 -7.178  1    41.5   ? 269 TYR A CA  1 
ATOM   2192 C  C   . TYR A 1 273 ? -4.827  -30.896 -7.607  1    44.86  ? 269 TYR A C   1 
ATOM   2193 O  O   . TYR A 1 273 ? -4.671  -29.739 -7.175  1    50.56  ? 269 TYR A O   1 
ATOM   2194 C  CB  . TYR A 1 273 ? -2.853  -32.313 -8.257  1    37.44  ? 269 TYR A CB  1 
ATOM   2195 C  CG  . TYR A 1 273 ? -1.519  -32.81  -7.723  1    38.3   ? 269 TYR A CG  1 
ATOM   2196 C  CD1 . TYR A 1 273 ? -0.645  -31.947 -7.086  1    39.22  ? 269 TYR A CD1 1 
ATOM   2197 C  CD2 . TYR A 1 273 ? -1.156  -34.145 -7.82   1    38     ? 269 TYR A CD2 1 
ATOM   2198 C  CE1 . TYR A 1 273 ? 0.564   -32.385 -6.581  1    39.71  ? 269 TYR A CE1 1 
ATOM   2199 C  CE2 . TYR A 1 273 ? 0.047   -34.6   -7.318  1    39.57  ? 269 TYR A CE2 1 
ATOM   2200 C  CZ  . TYR A 1 273 ? 0.925   -33.713 -6.71   1    39.76  ? 269 TYR A CZ  1 
ATOM   2201 O  OH  . TYR A 1 273 ? 2.129   -34.128 -6.2    1    40.13  ? 269 TYR A OH  1 
ATOM   2202 N  N   . ASP A 1 274 ? -5.762  -31.27  -8.487  1    42.18  ? 270 ASP A N   1 
ATOM   2203 C  CA  . ASP A 1 274 ? -6.6    -30.307 -9.183  1    44.12  ? 270 ASP A CA  1 
ATOM   2204 C  C   . ASP A 1 274 ? -7.593  -29.751 -8.172  1    42.85  ? 270 ASP A C   1 
ATOM   2205 O  O   . ASP A 1 274 ? -8.429  -30.497 -7.68   1    44.98  ? 270 ASP A O   1 
ATOM   2206 C  CB  . ASP A 1 274 ? -7.323  -30.94  -10.364 1    41.82  ? 270 ASP A CB  1 
ATOM   2207 C  CG  . ASP A 1 274 ? -8.037  -29.949 -11.27  1    48.12  ? 270 ASP A CG  1 
ATOM   2208 O  OD1 . ASP A 1 274 ? -8.156  -28.75  -10.87  1    45.53  ? 270 ASP A OD1 1 
ATOM   2209 O  OD2 . ASP A 1 274 ? -8.451  -30.374 -12.393 1    55.05  ? 270 ASP A OD2 1 
ATOM   2210 N  N   . PRO A 1 275 ? -7.529  -28.461 -7.786  1    44.38  ? 271 PRO A N   1 
ATOM   2211 C  CA  . PRO A 1 275 ? -8.447  -27.928 -6.78   1    41.86  ? 271 PRO A CA  1 
ATOM   2212 C  C   . PRO A 1 275 ? -9.899  -28.136 -7.199  1    41.87  ? 271 PRO A C   1 
ATOM   2213 O  O   . PRO A 1 275 ? -10.765 -28.301 -6.328  1    47.73  ? 271 PRO A O   1 
ATOM   2214 C  CB  . PRO A 1 275 ? -8.062  -26.424 -6.658  1    39.26  ? 271 PRO A CB  1 
ATOM   2215 C  CG  . PRO A 1 275 ? -6.673  -26.344 -7.18   1    41.38  ? 271 PRO A CG  1 
ATOM   2216 C  CD  . PRO A 1 275 ? -6.564  -27.451 -8.25   1    46.99  ? 271 PRO A CD  1 
ATOM   2217 N  N   . ASN A 1 276 ? -10.133 -28.154 -8.525  1    37.83  ? 272 ASN A N   1 
ATOM   2218 C  CA  . ASN A 1 276 ? -11.464 -28.361 -9.093  1    40.53  ? 272 ASN A CA  1 
ATOM   2219 C  C   . ASN A 1 276 ? -12.027 -29.764 -8.826  1    37.01  ? 272 ASN A C   1 
ATOM   2220 O  O   . ASN A 1 276 ? -13.239 -29.897 -8.763  1    38.79  ? 272 ASN A O   1 
ATOM   2221 C  CB  . ASN A 1 276 ? -11.485 -28.098 -10.6   1    44.87  ? 272 ASN A CB  1 
ATOM   2222 C  CG  . ASN A 1 276 ? -11.256 -26.643 -10.941 1    47.79  ? 272 ASN A CG  1 
ATOM   2223 O  OD1 . ASN A 1 276 ? -11.565 -25.746 -10.157 1    53.14  ? 272 ASN A OD1 1 
ATOM   2224 N  ND2 . ASN A 1 276 ? -10.724 -26.376 -12.113 1    50.97  ? 272 ASN A ND2 1 
ATOM   2225 N  N   . LYS A 1 277 ? -11.185 -30.81  -8.728  1    38.75  ? 273 LYS A N   1 
ATOM   2226 C  CA  . LYS A 1 277 ? -11.604 -32.186 -8.493  1    40.36  ? 273 LYS A CA  1 
ATOM   2227 C  C   . LYS A 1 277 ? -11.488 -32.561 -7.019  1    39.04  ? 273 LYS A C   1 
ATOM   2228 O  O   . LYS A 1 277 ? -12.003 -33.582 -6.59   1    38.18  ? 273 LYS A O   1 
ATOM   2229 C  CB  . LYS A 1 277 ? -10.743 -33.205 -9.247  1    46.22  ? 273 LYS A CB  1 
ATOM   2230 C  CG  . LYS A 1 277 ? -10.61  -33.007 -10.755 1    61.85  ? 273 LYS A CG  1 
ATOM   2231 C  CD  . LYS A 1 277 ? -11.913 -32.742 -11.504 1    76.86  ? 273 LYS A CD  1 
ATOM   2232 C  CE  . LYS A 1 277 ? -11.754 -32.803 -13.002 1    86.43  ? 273 LYS A CE  1 
ATOM   2233 N  NZ  . LYS A 1 277 ? -12.866 -32.129 -13.682 1    95.59  ? 273 LYS A NZ  1 
ATOM   2234 N  N   . ARG A 1 278 ? -10.749 -31.778 -6.235  1    37.83  ? 274 ARG A N   1 
ATOM   2235 C  CA  . ARG A 1 278 ? -10.597 -32.129 -4.826  1    36.02  ? 274 ARG A CA  1 
ATOM   2236 C  C   . ARG A 1 278 ? -11.994 -32.145 -4.204  1    33.28  ? 274 ARG A C   1 
ATOM   2237 O  O   . ARG A 1 278 ? -12.838 -31.339 -4.575  1    31.5   ? 274 ARG A O   1 
ATOM   2238 C  CB  . ARG A 1 278 ? -9.642  -31.094 -4.234  1    35.44  ? 274 ARG A CB  1 
ATOM   2239 C  CG  . ARG A 1 278 ? -9.066  -31.412 -2.868  1    40.94  ? 274 ARG A CG  1 
ATOM   2240 C  CD  . ARG A 1 278 ? -8.047  -30.363 -2.394  1    36.6   ? 274 ARG A CD  1 
ATOM   2241 N  NE  . ARG A 1 278 ? -6.979  -30.13  -3.374  1    42.47  ? 274 ARG A NE  1 
ATOM   2242 C  CZ  . ARG A 1 278 ? -6.295  -28.985 -3.483  1    38.76  ? 274 ARG A CZ  1 
ATOM   2243 N  NH1 . ARG A 1 278 ? -6.467  -28.034 -2.602  1    33.48  ? 274 ARG A NH1 1 
ATOM   2244 N  NH2 . ARG A 1 278 ? -5.435  -28.819 -4.473  1    35.51  ? 274 ARG A NH2 1 
ATOM   2245 N  N   . ILE A 1 279 ? -12.248 -33.069 -3.28   1    32.2   ? 275 ILE A N   1 
ATOM   2246 C  CA  . ILE A 1 279 ? -13.578 -33.185 -2.703  1    31.99  ? 275 ILE A CA  1 
ATOM   2247 C  C   . ILE A 1 279 ? -13.906 -31.949 -1.869  1    32.36  ? 275 ILE A C   1 
ATOM   2248 O  O   . ILE A 1 279 ? -13.012 -31.394 -1.255  1    37.46  ? 275 ILE A O   1 
ATOM   2249 C  CB  . ILE A 1 279 ? -13.678 -34.481 -1.871  1    33.56  ? 275 ILE A CB  1 
ATOM   2250 C  CG1 . ILE A 1 279 ? -15.098 -34.787 -1.439  1    33.48  ? 275 ILE A CG1 1 
ATOM   2251 C  CG2 . ILE A 1 279 ? -12.72  -34.489 -0.691  1    30.99  ? 275 ILE A CG2 1 
ATOM   2252 C  CD1 . ILE A 1 279 ? -15.366 -36.252 -1.204  1    34.54  ? 275 ILE A CD1 1 
ATOM   2253 N  N   . SER A 1 280 ? -15.177 -31.537 -1.828  1    34.97  ? 276 SER A N   1 
ATOM   2254 C  CA  . SER A 1 280 ? -15.664 -30.514 -0.901  1    35.87  ? 276 SER A CA  1 
ATOM   2255 C  C   . SER A 1 280 ? -15.981 -31.113 0.475   1    40.44  ? 276 SER A C   1 
ATOM   2256 O  O   . SER A 1 280 ? -16.269 -32.309 0.579   1    37.94  ? 276 SER A O   1 
ATOM   2257 C  CB  . SER A 1 280 ? -16.897 -29.834 -1.428  1    35.3   ? 276 SER A CB  1 
ATOM   2258 O  OG  . SER A 1 280 ? -18.003 -30.724 -1.353  1    33.36  ? 276 SER A OG  1 
ATOM   2259 N  N   . ALA A 1 281 ? -15.986 -30.264 1.519   1    39.46  ? 277 ALA A N   1 
ATOM   2260 C  CA  . ALA A 1 281 ? -16.315 -30.742 2.853   1    40.38  ? 277 ALA A CA  1 
ATOM   2261 C  C   . ALA A 1 281 ? -17.717 -31.342 2.862   1    38.84  ? 277 ALA A C   1 
ATOM   2262 O  O   . ALA A 1 281 ? -17.975 -32.377 3.482   1    40.32  ? 277 ALA A O   1 
ATOM   2263 C  CB  . ALA A 1 281 ? -16.168 -29.629 3.868   1    40.24  ? 277 ALA A CB  1 
ATOM   2264 N  N   . LYS A 1 282 ? -18.62  -30.667 2.158   1    39.8   ? 278 LYS A N   1 
ATOM   2265 C  CA  . LYS A 1 282 ? -20.024 -31.046 2.069   1    40.55  ? 278 LYS A CA  1 
ATOM   2266 C  C   . LYS A 1 282 ? -20.174 -32.438 1.448   1    37.26  ? 278 LYS A C   1 
ATOM   2267 O  O   . LYS A 1 282 ? -20.814 -33.305 2.009   1    43.31  ? 278 LYS A O   1 
ATOM   2268 C  CB  . LYS A 1 282 ? -20.708 -29.861 1.379   1    41.11  ? 278 LYS A CB  1 
ATOM   2269 C  CG  . LYS A 1 282 ? -22.082 -30.055 0.829   1    46.45  ? 278 LYS A CG  1 
ATOM   2270 C  CD  . LYS A 1 282 ? -22.632 -28.814 0.13    1    53.49  ? 278 LYS A CD  1 
ATOM   2271 C  CE  . LYS A 1 282 ? -22.804 -27.594 0.978   1    47.44  ? 278 LYS A CE  1 
ATOM   2272 N  NZ  . LYS A 1 282 ? -23.93  -26.823 0.454   1    42.22  ? 278 LYS A NZ  1 
ATOM   2273 N  N   . ALA A 1 283 ? -19.477 -32.72  0.364   1    44.31  ? 279 ALA A N   1 
ATOM   2274 C  CA  . ALA A 1 283 ? -19.53  -34.046 -0.276  1    46.63  ? 279 ALA A CA  1 
ATOM   2275 C  C   . ALA A 1 283 ? -18.823 -35.113 0.561   1    38.19  ? 279 ALA A C   1 
ATOM   2276 O  O   . ALA A 1 283 ? -19.259 -36.26  0.619   1    46.8   ? 279 ALA A O   1 
ATOM   2277 C  CB  . ALA A 1 283 ? -18.973 -34.019 -1.708  1    41.2   ? 279 ALA A CB  1 
ATOM   2278 N  N   . ALA A 1 284 ? -17.723 -34.737 1.188   1    33.91  ? 280 ALA A N   1 
ATOM   2279 C  CA  . ALA A 1 284 ? -16.95  -35.681 1.98    1    35.11  ? 280 ALA A CA  1 
ATOM   2280 C  C   . ALA A 1 284 ? -17.763 -36.228 3.153   1    35.52  ? 280 ALA A C   1 
ATOM   2281 O  O   . ALA A 1 284 ? -17.483 -37.333 3.59    1    38.73  ? 280 ALA A O   1 
ATOM   2282 C  CB  . ALA A 1 284 ? -15.663 -35.063 2.431   1    29.17  ? 280 ALA A CB  1 
ATOM   2283 N  N   . LEU A 1 285 ? -18.755 -35.482 3.656   1    33.67  ? 281 LEU A N   1 
ATOM   2284 C  CA  . LEU A 1 285 ? -19.543 -35.961 4.792   1    35.12  ? 281 LEU A CA  1 
ATOM   2285 C  C   . LEU A 1 285 ? -20.308 -37.227 4.433   1    38.69  ? 281 LEU A C   1 
ATOM   2286 O  O   . LEU A 1 285 ? -20.744 -37.937 5.338   1    43.01  ? 281 LEU A O   1 
ATOM   2287 C  CB  . LEU A 1 285 ? -20.537 -34.91  5.274   1    37.51  ? 281 LEU A CB  1 
ATOM   2288 C  CG  . LEU A 1 285 ? -19.937 -33.689 5.982   1    39.47  ? 281 LEU A CG  1 
ATOM   2289 C  CD1 . LEU A 1 285 ? -20.998 -32.617 6.18    1    35.52  ? 281 LEU A CD1 1 
ATOM   2290 C  CD2 . LEU A 1 285 ? -19.362 -34.113 7.319   1    40.57  ? 281 LEU A CD2 1 
ATOM   2291 N  N   . ALA A 1 286 ? -20.547 -37.461 3.132   1    38.19  ? 282 ALA A N   1 
ATOM   2292 C  CA  . ALA A 1 286 ? -21.335 -38.599 2.68    1    39.24  ? 282 ALA A CA  1 
ATOM   2293 C  C   . ALA A 1 286 ? -20.447 -39.79  2.341   1    40.62  ? 282 ALA A C   1 
ATOM   2294 O  O   . ALA A 1 286 ? -20.975 -40.842 1.979   1    45.08  ? 282 ALA A O   1 
ATOM   2295 C  CB  . ALA A 1 286 ? -22.141 -38.225 1.472   1    38.35  ? 282 ALA A CB  1 
ATOM   2296 N  N   . HIS A 1 287 ? -19.118 -39.615 2.421   1    38.94  ? 283 HIS A N   1 
ATOM   2297 C  CA  . HIS A 1 287 ? -18.196 -40.676 2.037   1    39.89  ? 283 HIS A CA  1 
ATOM   2298 C  C   . HIS A 1 287 ? -18.394 -41.929 2.889   1    41.11  ? 283 HIS A C   1 
ATOM   2299 O  O   . HIS A 1 287 ? -18.554 -41.855 4.11    1    44.85  ? 283 HIS A O   1 
ATOM   2300 C  CB  . HIS A 1 287 ? -16.751 -40.201 2.121   1    37.77  ? 283 HIS A CB  1 
ATOM   2301 C  CG  . HIS A 1 287 ? -15.802 -41.126 1.452   1    47.17  ? 283 HIS A CG  1 
ATOM   2302 N  ND1 . HIS A 1 287 ? -15.373 -42.322 2.014   1    50.13  ? 283 HIS A ND1 1 
ATOM   2303 C  CD2 . HIS A 1 287 ? -15.151 -41.006 0.263   1    49.03  ? 283 HIS A CD2 1 
ATOM   2304 C  CE1 . HIS A 1 287 ? -14.513 -42.915 1.181   1    49.73  ? 283 HIS A CE1 1 
ATOM   2305 N  NE2 . HIS A 1 287 ? -14.363 -42.134 0.104   1    47.12  ? 283 HIS A NE2 1 
ATOM   2306 N  N   . PRO A 1 288 ? -18.385 -43.122 2.26    1    41.87  ? 284 PRO A N   1 
ATOM   2307 C  CA  . PRO A 1 288 ? -18.541 -44.391 2.98    1    40.76  ? 284 PRO A CA  1 
ATOM   2308 C  C   . PRO A 1 288 ? -17.661 -44.596 4.212   1    40.28  ? 284 PRO A C   1 
ATOM   2309 O  O   . PRO A 1 288 ? -18.013 -45.387 5.105   1    42.91  ? 284 PRO A O   1 
ATOM   2310 C  CB  . PRO A 1 288 ? -18.274 -45.486 1.95    1    39.12  ? 284 PRO A CB  1 
ATOM   2311 C  CG  . PRO A 1 288 ? -18.396 -44.804 0.62    1    39.85  ? 284 PRO A CG  1 
ATOM   2312 C  CD  . PRO A 1 288 ? -18.182 -43.306 0.81    1    39.97  ? 284 PRO A CD  1 
ATOM   2313 N  N   . PHE A 1 289 ? -16.53  -43.883 4.267   1    37.4   ? 285 PHE A N   1 
ATOM   2314 C  CA  . PHE A 1 289 ? -15.629 -44.018 5.405   1    39.88  ? 285 PHE A CA  1 
ATOM   2315 C  C   . PHE A 1 289 ? -16.367 -43.701 6.718   1    42.84  ? 285 PHE A C   1 
ATOM   2316 O  O   . PHE A 1 289 ? -16.018 -44.23  7.775   1    45.43  ? 285 PHE A O   1 
ATOM   2317 C  CB  . PHE A 1 289 ? -14.394 -43.156 5.154   1    40.07  ? 285 PHE A CB  1 
ATOM   2318 C  CG  . PHE A 1 289 ? -13.386 -43.138 6.285   1    44.92  ? 285 PHE A CG  1 
ATOM   2319 C  CD1 . PHE A 1 289 ? -12.534 -44.222 6.514   1    42.88  ? 285 PHE A CD1 1 
ATOM   2320 C  CD2 . PHE A 1 289 ? -13.296 -42.015 7.12    1    46.31  ? 285 PHE A CD2 1 
ATOM   2321 C  CE1 . PHE A 1 289 ? -11.607 -44.174 7.543   1    41.18  ? 285 PHE A CE1 1 
ATOM   2322 C  CE2 . PHE A 1 289 ? -12.386 -41.986 8.178   1    42.97  ? 285 PHE A CE2 1 
ATOM   2323 C  CZ  . PHE A 1 289 ? -11.532 -43.06  8.373   1    41.31  ? 285 PHE A CZ  1 
ATOM   2324 N  N   . PHE A 1 290 ? -17.421 -42.87  6.643   1    38.97  ? 286 PHE A N   1 
ATOM   2325 C  CA  . PHE A 1 290 ? -18.075 -42.396 7.84    1    40.86  ? 286 PHE A CA  1 
ATOM   2326 C  C   . PHE A 1 290 ? -19.302 -43.242 8.215   1    50.47  ? 286 PHE A C   1 
ATOM   2327 O  O   . PHE A 1 290 ? -19.904 -42.98  9.273   1    50.46  ? 286 PHE A O   1 
ATOM   2328 C  CB  . PHE A 1 290 ? -18.436 -40.925 7.653   1    38.11  ? 286 PHE A CB  1 
ATOM   2329 C  CG  . PHE A 1 290 ? -17.223 -40.029 7.517   1    35.14  ? 286 PHE A CG  1 
ATOM   2330 C  CD1 . PHE A 1 290 ? -16.304 -39.949 8.55    1    35.54  ? 286 PHE A CD1 1 
ATOM   2331 C  CD2 . PHE A 1 290 ? -17.035 -39.243 6.386   1    33.85  ? 286 PHE A CD2 1 
ATOM   2332 C  CE1 . PHE A 1 290 ? -15.209 -39.107 8.428   1    35.74  ? 286 PHE A CE1 1 
ATOM   2333 C  CE2 . PHE A 1 290 ? -15.938 -38.41  6.267   1    32.49  ? 286 PHE A CE2 1 
ATOM   2334 C  CZ  . PHE A 1 290 ? -15.02  -38.341 7.293   1    33.9   ? 286 PHE A CZ  1 
ATOM   2335 N  N   . GLN A 1 291 ? -19.622 -44.268 7.397   1    50.15  ? 287 GLN A N   1 
ATOM   2336 C  CA  . GLN A 1 291 ? -20.843 -45.04  7.546   1    57.99  ? 287 GLN A CA  1 
ATOM   2337 C  C   . GLN A 1 291 ? -21.112 -45.393 9.008   1    66.77  ? 287 GLN A C   1 
ATOM   2338 O  O   . GLN A 1 291 ? -22.271 -45.41  9.432   1    84.14  ? 287 GLN A O   1 
ATOM   2339 C  CB  . GLN A 1 291 ? -20.918 -46.247 6.608   1    62.73  ? 287 GLN A CB  1 
ATOM   2340 C  CG  . GLN A 1 291 ? -19.941 -47.392 6.879   1    73.12  ? 287 GLN A CG  1 
ATOM   2341 C  CD  . GLN A 1 291 ? -20.067 -48.509 5.841   1    84.82  ? 287 GLN A CD  1 
ATOM   2342 O  OE1 . GLN A 1 291 ? -21.036 -49.286 5.844   1    94.6   ? 287 GLN A OE1 1 
ATOM   2343 N  NE2 . GLN A 1 291 ? -19.131 -48.582 4.895   1    67.52  ? 287 GLN A NE2 1 
ATOM   2344 N  N   . ASP A 1 292 ? -20.061 -45.697 9.78    1    64.66  ? 288 ASP A N   1 
ATOM   2345 C  CA  . ASP A 1 292 ? -20.265 -46.336 11.079  1    71.36  ? 288 ASP A CA  1 
ATOM   2346 C  C   . ASP A 1 292 ? -19.851 -45.418 12.24   1    69.78  ? 288 ASP A C   1 
ATOM   2347 O  O   . ASP A 1 292 ? -19.49  -45.937 13.298  1    64.72  ? 288 ASP A O   1 
ATOM   2348 C  CB  . ASP A 1 292 ? -19.603 -47.712 11.138  1    74.93  ? 288 ASP A CB  1 
ATOM   2349 C  CG  . ASP A 1 292 ? -18.118 -47.717 10.777  1    84.3   ? 288 ASP A CG  1 
ATOM   2350 O  OD1 . ASP A 1 292 ? -17.599 -46.671 10.269  1    78.82  ? 288 ASP A OD1 1 
ATOM   2351 O  OD2 . ASP A 1 292 ? -17.486 -48.77  10.971  1    86.19  ? 288 ASP A OD2 1 
ATOM   2352 N  N   . VAL A 1 293 ? -19.913 -44.081 12.067  1    65.06  ? 289 VAL A N   1 
ATOM   2353 C  CA  . VAL A 1 293 ? -19.755 -43.166 13.196  1    64.52  ? 289 VAL A CA  1 
ATOM   2354 C  C   . VAL A 1 293 ? -21.107 -42.985 13.876  1    75.58  ? 289 VAL A C   1 
ATOM   2355 O  O   . VAL A 1 293 ? -22.068 -42.717 13.161  1    84.23  ? 289 VAL A O   1 
ATOM   2356 C  CB  . VAL A 1 293 ? -19.176 -41.795 12.805  1    61.57  ? 289 VAL A CB  1 
ATOM   2357 C  CG1 . VAL A 1 293 ? -17.719 -41.891 12.429  1    67.32  ? 289 VAL A CG1 1 
ATOM   2358 C  CG2 . VAL A 1 293 ? -19.922 -41.145 11.663  1    62.73  ? 289 VAL A CG2 1 
ATOM   2359 N  N   . THR A 1 294 ? -21.203 -43.14  15.215  1    90.79  ? 290 THR A N   1 
ATOM   2360 C  CA  . THR A 1 294 ? -22.493 -42.908 15.872  1    108.77 ? 290 THR A CA  1 
ATOM   2361 C  C   . THR A 1 294 ? -22.342 -42.092 17.157  1    119.71 ? 290 THR A C   1 
ATOM   2362 O  O   . THR A 1 294 ? -23.18  -42.234 18.046  1    123.19 ? 290 THR A O   1 
ATOM   2363 C  CB  . THR A 1 294 ? -23.293 -44.188 16.144  1    108.98 ? 290 THR A CB  1 
ATOM   2364 O  OG1 . THR A 1 294 ? -22.593 -45.107 16.966  1    96.55  ? 290 THR A OG1 1 
ATOM   2365 C  CG2 . THR A 1 294 ? -23.582 -44.97  14.877  1    115.01 ? 290 THR A CG2 1 
ATOM   2366 N  N   . LYS A 1 295 ? -21.289 -41.253 17.236  1    137.41 ? 291 LYS A N   1 
ATOM   2367 C  CA  . LYS A 1 295 ? -21.093 -40.266 18.293  1    137.02 ? 291 LYS A CA  1 
ATOM   2368 C  C   . LYS A 1 295 ? -22.069 -39.101 18.09   1    137.14 ? 291 LYS A C   1 
ATOM   2369 O  O   . LYS A 1 295 ? -22.018 -38.483 17.033  1    149.78 ? 291 LYS A O   1 
ATOM   2370 C  CB  . LYS A 1 295 ? -19.65  -39.738 18.233  1    100.01 ? 291 LYS A CB  1 
ATOM   2371 C  CG  . LYS A 1 295 ? -19.231 -38.676 19.236  1    88.87  ? 291 LYS A CG  1 
ATOM   2372 C  CD  . LYS A 1 295 ? -19.349 -39.249 20.642  1    102    ? 291 LYS A CD  1 
ATOM   2373 C  CE  . LYS A 1 295 ? -18.81  -38.363 21.721  1    103.88 ? 291 LYS A CE  1 
ATOM   2374 N  NZ  . LYS A 1 295 ? -19.195 -38.957 22.997  1    104.85 ? 291 LYS A NZ  1 
ATOM   2375 N  N   . PRO A 1 296 ? -22.983 -38.767 19.046  1    140.3  ? 292 PRO A N   1 
ATOM   2376 C  CA  . PRO A 1 296 ? -24.006 -37.726 18.815  1    133.06 ? 292 PRO A CA  1 
ATOM   2377 C  C   . PRO A 1 296 ? -23.456 -36.373 18.407  1    123.2  ? 292 PRO A C   1 
ATOM   2378 O  O   . PRO A 1 296 ? -22.561 -35.876 19.089  1    126.24 ? 292 PRO A O   1 
ATOM   2379 C  CB  . PRO A 1 296 ? -24.808 -37.55  20.107  1    128.36 ? 292 PRO A CB  1 
ATOM   2380 C  CG  . PRO A 1 296 ? -24.142 -38.511 21.076  1    133.37 ? 292 PRO A CG  1 
ATOM   2381 C  CD  . PRO A 1 296 ? -23.114 -39.404 20.373  1    140.23 ? 292 PRO A CD  1 
ATOM   2382 N  N   . VAL A 1 297 ? -24.027 -35.802 17.342  1    113.09 ? 293 VAL A N   1 
ATOM   2383 C  CA  . VAL A 1 297 ? -23.554 -34.493 16.948  1    120.49 ? 293 VAL A CA  1 
ATOM   2384 C  C   . VAL A 1 297 ? -23.499 -33.716 18.265  1    119.93 ? 293 VAL A C   1 
ATOM   2385 O  O   . VAL A 1 297 ? -24.477 -33.716 19.03   1    89.08  ? 293 VAL A O   1 
ATOM   2386 C  CB  . VAL A 1 297 ? -24.359 -33.821 15.811  1    100.74 ? 293 VAL A CB  1 
ATOM   2387 C  CG1 . VAL A 1 297 ? -25.839 -33.88  16.131  1    103.89 ? 293 VAL A CG1 1 
ATOM   2388 C  CG2 . VAL A 1 297 ? -23.898 -32.39  15.474  1    77.77  ? 293 VAL A CG2 1 
ATOM   2389 N  N   . PRO A 1 298 ? -22.368 -33.064 18.625  1    118    ? 294 PRO A N   1 
ATOM   2390 C  CA  . PRO A 1 298 ? -22.353 -32.302 19.858  1    111.08 ? 294 PRO A CA  1 
ATOM   2391 C  C   . PRO A 1 298 ? -23.285 -31.106 19.728  1    104.83 ? 294 PRO A C   1 
ATOM   2392 O  O   . PRO A 1 298 ? -23.63  -30.71  18.602  1    103.59 ? 294 PRO A O   1 
ATOM   2393 C  CB  . PRO A 1 298 ? -20.866 -31.963 19.984  1    99.23  ? 294 PRO A CB  1 
ATOM   2394 C  CG  . PRO A 1 298 ? -20.374 -31.853 18.566  1    94.09  ? 294 PRO A CG  1 
ATOM   2395 C  CD  . PRO A 1 298 ? -21.077 -33     17.905  1    98.64  ? 294 PRO A CD  1 
ATOM   2396 N  N   . HIS A 1 299 ? -23.728 -30.551 20.853  1    107.25 ? 295 HIS A N   1 
ATOM   2397 C  CA  . HIS A 1 299 ? -24.744 -29.464 20.786  1    107.45 ? 295 HIS A CA  1 
ATOM   2398 C  C   . HIS A 1 299 ? -24.092 -28.086 20.691  1    100.48 ? 295 HIS A C   1 
ATOM   2399 O  O   . HIS A 1 299 ? -22.933 -27.903 21.113  1    99.84  ? 295 HIS A O   1 
ATOM   2400 C  CB  . HIS A 1 299 ? -25.678 -29.518 21.997  1    112.29 ? 295 HIS A CB  1 
ATOM   2401 C  CG  . HIS A 1 299 ? -26.929 -30.277 21.734  1    136.07 ? 295 HIS A CG  1 
ATOM   2402 N  ND1 . HIS A 1 299 ? -27.774 -29.967 20.692  1    144.46 ? 295 HIS A ND1 1 
ATOM   2403 C  CD2 . HIS A 1 299 ? -27.472 -31.329 22.354  1    130.03 ? 295 HIS A CD2 1 
ATOM   2404 C  CE1 . HIS A 1 299 ? -28.792 -30.812 20.693  1    141.54 ? 295 HIS A CE1 1 
ATOM   2405 N  NE2 . HIS A 1 299 ? -28.631 -31.645 21.697  1    140.85 ? 295 HIS A NE2 1 
ATOM   2406 N  N   . LEU A 1 300 ? -24.83  -27.133 20.13   1    91.65  ? 296 LEU A N   1 
ATOM   2407 C  CA  . LEU A 1 300 ? -24.298 -25.754 20.03   1    100.73 ? 296 LEU A CA  1 
ATOM   2408 C  C   . LEU A 1 300 ? -24.257 -25.173 21.445  1    122.99 ? 296 LEU A C   1 
ATOM   2409 O  O   . LEU A 1 300 ? -24.911 -25.729 22.337  1    154.87 ? 296 LEU A O   1 
ATOM   2410 C  CB  . LEU A 1 300 ? -25.15  -24.908 19.088  1    93.45  ? 296 LEU A CB  1 
ATOM   2411 C  CG  . LEU A 1 300 ? -24.404 -24.287 17.904  1    99.53  ? 296 LEU A CG  1 
ATOM   2412 C  CD1 . LEU A 1 300 ? -25.373 -23.771 16.861  1    89.07  ? 296 LEU A CD1 1 
ATOM   2413 C  CD2 . LEU A 1 300 ? -23.457 -23.188 18.355  1    79.79  ? 296 LEU A CD2 1 
ATOM   2414 N  N   . ARG A 1 301 ? -23.48  -24.115 21.641  1    123.77 ? 297 ARG A N   1 
ATOM   2415 C  CA  . ARG A 1 301 ? -23.388 -23.484 22.976  1    124.07 ? 297 ARG A CA  1 
ATOM   2416 C  C   . ARG A 1 301 ? -24.22  -22.195 22.954  1    108.4  ? 297 ARG A C   1 
ATOM   2417 O  O   . ARG A 1 301 ? -24.662 -21.802 21.859  1    82.95  ? 297 ARG A O   1 
ATOM   2418 C  CB  . ARG A 1 301 ? -21.901 -23.29  23.287  1    120.99 ? 297 ARG A CB  1 
ATOM   2419 C  CG  . ARG A 1 301 ? -21.095 -24.58  23.247  1    108.91 ? 297 ARG A CG  1 
ATOM   2420 C  CD  . ARG A 1 301 ? -20.727 -25.003 24.655  1    102.26 ? 297 ARG A CD  1 
ATOM   2421 N  NE  . ARG A 1 301 ? -20.525 -23.827 25.507  1    99.57  ? 297 ARG A NE  1 
ATOM   2422 C  CZ  . ARG A 1 301 ? -20.38  -23.868 26.821  1    101.7  ? 297 ARG A CZ  1 
ATOM   2423 N  NH1 . ARG A 1 301 ? -20.072 -22.772 27.486  1    87.92  ? 297 ARG A NH1 1 
ATOM   2424 N  NH2 . ARG A 1 301 ? -20.538 -25.008 27.464  1    101.3  ? 297 ARG A NH2 1 
ATOM   2425 N  N   . LEU A 1 302 ? -24.442 -21.592 24.121  1    105.3  ? 298 LEU A N   1 
ATOM   2426 C  CA  . LEU A 1 302 ? -25.216 -20.329 24.209  1    93.36  ? 298 LEU A CA  1 
ATOM   2427 C  C   . LEU A 1 302 ? -24.245 -19.179 24.498  1    89.22  ? 298 LEU A C   1 
ATOM   2428 O  O   . LEU A 1 302 ? -24.444 -18.112 23.883  1    97.24  ? 298 LEU A O   1 
ATOM   2429 C  CB  . LEU A 1 302 ? -26.293 -20.431 25.285  1    94.11  ? 298 LEU A CB  1 
ATOM   2430 C  CG  . LEU A 1 302 ? -27.399 -21.454 25.025  1    87.52  ? 298 LEU A CG  1 
ATOM   2431 C  CD1 . LEU A 1 302 ? -28.271 -21.512 26.252  1    79.05  ? 298 LEU A CD1 1 
ATOM   2432 C  CD2 . LEU A 1 302 ? -28.209 -21.077 23.805  1    87.46  ? 298 LEU A CD2 1 
ATOM   2433 N  N   . GLY B 2 1   ? -15.333 -23.935 -11.898 1    37.73  ? 171 GLY B N   1 
ATOM   2434 C  CA  . GLY B 2 1   ? -14.648 -24.797 -10.921 1    43.8   ? 171 GLY B CA  1 
ATOM   2435 C  C   . GLY B 2 1   ? -14.708 -24.228 -9.494  1    49.46  ? 171 GLY B C   1 
ATOM   2436 O  O   . GLY B 2 1   ? -15.589 -23.414 -9.147  1    51.44  ? 171 GLY B O   1 
ATOM   2437 N  N   . VAL B 2 2   ? -13.724 -24.637 -8.679  1    46.13  ? 172 VAL B N   1 
ATOM   2438 C  CA  . VAL B 2 2   ? -13.742 -24.34  -7.26   1    48.32  ? 172 VAL B CA  1 
ATOM   2439 C  C   . VAL B 2 2   ? -13.701 -22.825 -6.996  1    49.21  ? 172 VAL B C   1 
ATOM   2440 O  O   . VAL B 2 2   ? -14.213 -22.363 -5.961  1    47.2   ? 172 VAL B O   1 
ATOM   2441 C  CB  . VAL B 2 2   ? -12.626 -25.12  -6.547  1    51.83  ? 172 VAL B CB  1 
ATOM   2442 C  CG1 . VAL B 2 2   ? -11.265 -24.445 -6.759  1    46.37  ? 172 VAL B CG1 1 
ATOM   2443 C  CG2 . VAL B 2 2   ? -12.986 -25.367 -5.067  1    44.42  ? 172 VAL B CG2 1 
ATOM   2444 N  N   . ASN B 2 3   ? -13.128 -22.05  -7.935  1    46.02  ? 173 ASN B N   1 
ATOM   2445 C  CA  . ASN B 2 3   ? -13.025 -20.601 -7.757  1    46.08  ? 173 ASN B CA  1 
ATOM   2446 C  C   . ASN B 2 3   ? -14.416 -19.985 -7.674  1    45.9   ? 173 ASN B C   1 
ATOM   2447 O  O   . ASN B 2 3   ? -14.601 -18.916 -7.096  1    46.96  ? 173 ASN B O   1 
ATOM   2448 C  CB  . ASN B 2 3   ? -12.082 -19.942 -8.763  1    46.33  ? 173 ASN B CB  1 
ATOM   2449 C  CG  . ASN B 2 3   ? -10.643 -20.377 -8.575  1    49.75  ? 173 ASN B CG  1 
ATOM   2450 O  OD1 . ASN B 2 3   ? -10.271 -20.874 -7.496  1    51.41  ? 173 ASN B OD1 1 
ATOM   2451 N  ND2 . ASN B 2 3   ? -9.821  -20.23  -9.61   1    48.71  ? 173 ASN B ND2 1 
ATOM   2452 N  N   . GLU B 2 4   ? -15.386 -20.694 -8.261  1    49.4   ? 174 GLU B N   1 
ATOM   2453 C  CA  . GLU B 2 4   ? -16.792 -20.326 -8.213  1    52.18  ? 174 GLU B CA  1 
ATOM   2454 C  C   . GLU B 2 4   ? -17.554 -21.141 -7.167  1    48.47  ? 174 GLU B C   1 
ATOM   2455 O  O   . GLU B 2 4   ? -18.769 -21.145 -7.19   1    43.85  ? 174 GLU B O   1 
ATOM   2456 C  CB  . GLU B 2 4   ? -17.373 -20.609 -9.595  1    53.4   ? 174 GLU B CB  1 
ATOM   2457 C  CG  . GLU B 2 4   ? -16.494 -20.035 -10.7   1    55.72  ? 174 GLU B CG  1 
ATOM   2458 C  CD  . GLU B 2 4   ? -17.106 -20.164 -12.069 1    62.86  ? 174 GLU B CD  1 
ATOM   2459 O  OE1 . GLU B 2 4   ? -18.074 -20.964 -12.229 1    62.61  ? 174 GLU B OE1 1 
ATOM   2460 O  OE2 . GLU B 2 4   ? -16.6   -19.421 -12.939 1    65.31  ? 174 GLU B OE2 1 
ATOM   2461 N  N   . VAL B 2 5   ? -16.845 -21.851 -6.287  1    46.34  ? 175 VAL B N   1 
ATOM   2462 C  CA  . VAL B 2 5   ? -17.434 -22.661 -5.227  1    44.7   ? 175 VAL B CA  1 
ATOM   2463 C  C   . VAL B 2 5   ? -18.772 -23.259 -5.645  1    44.35  ? 175 VAL B C   1 
ATOM   2464 O  O   . VAL B 2 5   ? -19.794 -22.963 -5.021  1    42.22  ? 175 VAL B O   1 
ATOM   2465 C  CB  . VAL B 2 5   ? -17.567 -21.915 -3.874  1    41.29  ? 175 VAL B CB  1 
ATOM   2466 C  CG1 . VAL B 2 5   ? -16.203 -21.725 -3.236  1    43.03  ? 175 VAL B CG1 1 
ATOM   2467 C  CG2 . VAL B 2 5   ? -18.277 -20.573 -3.983  1    33.66  ? 175 VAL B CG2 1 
ATOM   2468 N  N   . PRO B 2 6   ? -18.814 -24.162 -6.65   1    46.42  ? 176 PRO B N   1 
ATOM   2469 C  CA  . PRO B 2 6   ? -20.066 -24.811 -7.061  1    44.56  ? 176 PRO B CA  1 
ATOM   2470 C  C   . PRO B 2 6   ? -20.878 -25.389 -5.889  1    47.91  ? 176 PRO B C   1 
ATOM   2471 O  O   . PRO B 2 6   ? -22.105 -25.267 -5.901  1    48.22  ? 176 PRO B O   1 
ATOM   2472 C  CB  . PRO B 2 6   ? -19.652 -25.924 -8.07   1    41.73  ? 176 PRO B CB  1 
ATOM   2473 C  CG  . PRO B 2 6   ? -18.133 -25.978 -8.013  1    39.36  ? 176 PRO B CG  1 
ATOM   2474 C  CD  . PRO B 2 6   ? -17.65  -24.651 -7.409  1    44.68  ? 176 PRO B CD  1 
ATOM   2475 N  N   . ASP B 2 7   ? -20.206 -26.008 -4.887  1    42.44  ? 177 ASP B N   1 
ATOM   2476 C  CA  . ASP B 2 7   ? -20.873 -26.696 -3.792  1    43.83  ? 177 ASP B CA  1 
ATOM   2477 C  C   . ASP B 2 7   ? -21.472 -25.741 -2.744  1    46.69  ? 177 ASP B C   1 
ATOM   2478 O  O   . ASP B 2 7   ? -22.263 -26.207 -1.922  1    47.82  ? 177 ASP B O   1 
ATOM   2479 C  CB  . ASP B 2 7   ? -20.024 -27.791 -3.16   1    42.92  ? 177 ASP B CB  1 
ATOM   2480 C  CG  . ASP B 2 7   ? -20.053 -29.123 -3.896  1    49.06  ? 177 ASP B CG  1 
ATOM   2481 O  OD1 . ASP B 2 7   ? -20.559 -29.131 -5.048  1    49.34  ? 177 ASP B OD1 1 
ATOM   2482 O  OD2 . ASP B 2 7   ? -19.593 -30.155 -3.316  1    45.63  ? 177 ASP B OD2 1 
ATOM   2483 N  N   . TYR B 2 8   ? -21.142 -24.43  -2.792  1    40.32  ? 178 TYR B N   1 
ATOM   2484 C  CA  . TYR B 2 8   ? -21.488 -23.492 -1.732  1    40.19  ? 178 TYR B CA  1 
ATOM   2485 C  C   . TYR B 2 8   ? -22.111 -22.184 -2.238  1    38.81  ? 178 TYR B C   1 
ATOM   2486 O  O   . TYR B 2 8   ? -22.59  -21.419 -1.412  1    39.3   ? 178 TYR B O   1 
ATOM   2487 C  CB  . TYR B 2 8   ? -20.293 -23.154 -0.822  1    38.84  ? 178 TYR B CB  1 
ATOM   2488 C  CG  . TYR B 2 8   ? -19.639 -24.356 -0.169  1    38.43  ? 178 TYR B CG  1 
ATOM   2489 C  CD1 . TYR B 2 8   ? -20.191 -24.923 0.979   1    38.82  ? 178 TYR B CD1 1 
ATOM   2490 C  CD2 . TYR B 2 8   ? -18.51  -24.959 -0.734  1    34.36  ? 178 TYR B CD2 1 
ATOM   2491 C  CE1 . TYR B 2 8   ? -19.601 -26.036 1.566   1    36.47  ? 178 TYR B CE1 1 
ATOM   2492 C  CE2 . TYR B 2 8   ? -17.932 -26.083 -0.173  1    33.77  ? 178 TYR B CE2 1 
ATOM   2493 C  CZ  . TYR B 2 8   ? -18.46  -26.605 1.006   1    36.75  ? 178 TYR B CZ  1 
ATOM   2494 O  OH  . TYR B 2 8   ? -17.889 -27.732 1.572   1    36.45  ? 178 TYR B OH  1 
ATOM   2495 N  N   . HIS B 2 9   ? -22.174 -21.922 -3.558  1    41.86  ? 179 HIS B N   1 
ATOM   2496 C  CA  . HIS B 2 9   ? -22.614 -20.603 -4.039  1    46.25  ? 179 HIS B CA  1 
ATOM   2497 C  C   . HIS B 2 9   ? -24.064 -20.288 -3.65   1    45.4   ? 179 HIS B C   1 
ATOM   2498 O  O   . HIS B 2 9   ? -24.396 -19.132 -3.4    1    44.08  ? 179 HIS B O   1 
ATOM   2499 C  CB  . HIS B 2 9   ? -22.323 -20.381 -5.534  1    51.44  ? 179 HIS B CB  1 
ATOM   2500 C  CG  . HIS B 2 9   ? -23.302 -21.007 -6.467  1    66.78  ? 179 HIS B CG  1 
ATOM   2501 N  ND1 . HIS B 2 9   ? -23.275 -22.336 -6.871  1    70.76  ? 179 HIS B ND1 1 
ATOM   2502 C  CD2 . HIS B 2 9   ? -24.367 -20.454 -7.062  1    63.35  ? 179 HIS B CD2 1 
ATOM   2503 C  CE1 . HIS B 2 9   ? -24.295 -22.581 -7.688  1    72.59  ? 179 HIS B CE1 1 
ATOM   2504 N  NE2 . HIS B 2 9   ? -24.983 -21.46  -7.8    1    75.91  ? 179 HIS B NE2 1 
ATOM   2505 N  N   . GLU B 2 10  ? -24.929 -21.323 -3.609  1    45.71  ? 180 GLU B N   1 
ATOM   2506 C  CA  . GLU B 2 10  ? -26.329 -21.163 -3.244  1    42.38  ? 180 GLU B CA  1 
ATOM   2507 C  C   . GLU B 2 10  ? -26.456 -20.891 -1.745  1    42.97  ? 180 GLU B C   1 
ATOM   2508 O  O   . GLU B 2 10  ? -27.172 -19.957 -1.344  1    45.48  ? 180 GLU B O   1 
ATOM   2509 C  CB  . GLU B 2 10  ? -27.168 -22.402 -3.483  1    45.63  ? 180 GLU B CB  1 
ATOM   2510 C  CG  . GLU B 2 10  ? -27.784 -22.525 -4.87   1    62.14  ? 180 GLU B CG  1 
ATOM   2511 C  CD  . GLU B 2 10  ? -28.922 -23.556 -4.835  1    80.86  ? 180 GLU B CD  1 
ATOM   2512 O  OE1 . GLU B 2 10  ? -29.781 -23.577 -3.895  1    75.88  ? 180 GLU B OE1 1 
ATOM   2513 O  OE2 . GLU B 2 10  ? -28.959 -24.361 -5.797  1    88.49  ? 180 GLU B OE2 1 
ATOM   2514 N  N   . ASP B 2 11  ? -25.801 -21.736 -0.932  1    38.6   ? 181 ASP B N   1 
ATOM   2515 C  CA  . ASP B 2 11  ? -25.739 -21.5   0.511   1    39.9   ? 181 ASP B CA  1 
ATOM   2516 C  C   . ASP B 2 11  ? -25.266 -20.075 0.76    1    40.21  ? 181 ASP B C   1 
ATOM   2517 O  O   . ASP B 2 11  ? -25.883 -19.371 1.55    1    44.33  ? 181 ASP B O   1 
ATOM   2518 C  CB  . ASP B 2 11  ? -24.851 -22.471 1.271   1    38.67  ? 181 ASP B CB  1 
ATOM   2519 C  CG  . ASP B 2 11  ? -25.371 -23.898 1.411   1    47.99  ? 181 ASP B CG  1 
ATOM   2520 O  OD1 . ASP B 2 11  ? -26.62  -24.116 1.326   1    49.37  ? 181 ASP B OD1 1 
ATOM   2521 O  OD2 . ASP B 2 11  ? -24.522 -24.797 1.596   1    48.77  ? 181 ASP B OD2 1 
ATOM   2522 N  N   . ILE B 2 12  ? -24.195 -19.653 0.064   1    37.61  ? 182 ILE B N   1 
ATOM   2523 C  CA  . ILE B 2 12  ? -23.618 -18.345 0.292   1    39.31  ? 182 ILE B CA  1 
ATOM   2524 C  C   . ILE B 2 12  ? -24.612 -17.271 -0.132  1    39.37  ? 182 ILE B C   1 
ATOM   2525 O  O   . ILE B 2 12  ? -24.835 -16.325 0.594   1    47.81  ? 182 ILE B O   1 
ATOM   2526 C  CB  . ILE B 2 12  ? -22.26  -18.202 -0.414  1    38.57  ? 182 ILE B CB  1 
ATOM   2527 C  CG1 . ILE B 2 12  ? -21.187 -19.052 0.267   1    35.92  ? 182 ILE B CG1 1 
ATOM   2528 C  CG2 . ILE B 2 12  ? -21.825 -16.739 -0.53   1    35.57  ? 182 ILE B CG2 1 
ATOM   2529 C  CD1 . ILE B 2 12  ? -19.954 -19.286 -0.599  1    33.96  ? 182 ILE B CD1 1 
ATOM   2530 N  N   . HIS B 2 13  ? -25.206 -17.399 -1.311  1    40.48  ? 183 HIS B N   1 
ATOM   2531 C  CA  . HIS B 2 13  ? -26.182 -16.414 -1.764  1    40.24  ? 183 HIS B CA  1 
ATOM   2532 C  C   . HIS B 2 13  ? -27.327 -16.253 -0.746  1    42.85  ? 183 HIS B C   1 
ATOM   2533 O  O   . HIS B 2 13  ? -27.704 -15.147 -0.371  1    44.02  ? 183 HIS B O   1 
ATOM   2534 C  CB  . HIS B 2 13  ? -26.768 -16.84  -3.116  1    38.44  ? 183 HIS B CB  1 
ATOM   2535 C  CG  . HIS B 2 13  ? -27.842 -15.918 -3.573  1    35.79  ? 183 HIS B CG  1 
ATOM   2536 N  ND1 . HIS B 2 13  ? -27.554 -14.64  -4.017  1    36.43  ? 183 HIS B ND1 1 
ATOM   2537 C  CD2 . HIS B 2 13  ? -29.17  -16.047 -3.618  1    33.99  ? 183 HIS B CD2 1 
ATOM   2538 C  CE1 . HIS B 2 13  ? -28.672 -14.016 -4.343  1    33.6   ? 183 HIS B CE1 1 
ATOM   2539 N  NE2 . HIS B 2 13  ? -29.657 -14.855 -4.097  1    37.87  ? 183 HIS B NE2 1 
ATOM   2540 N  N   . THR B 2 14  ? -27.928 -17.37  -0.317  1    38.43  ? 184 THR B N   1 
ATOM   2541 C  CA  . THR B 2 14  ? -28.994 -17.324 0.659   1    36.72  ? 184 THR B CA  1 
ATOM   2542 C  C   . THR B 2 14  ? -28.532 -16.606 1.929   1    41.11  ? 184 THR B C   1 
ATOM   2543 O  O   . THR B 2 14  ? -29.29  -15.848 2.522   1    47.45  ? 184 THR B O   1 
ATOM   2544 C  CB  . THR B 2 14  ? -29.429 -18.737 1.025   1    37.59  ? 184 THR B CB  1 
ATOM   2545 O  OG1 . THR B 2 14  ? -30.114 -19.226 -0.127  1    39.93  ? 184 THR B OG1 1 
ATOM   2546 C  CG2 . THR B 2 14  ? -30.314 -18.739 2.271   1    31.92  ? 184 THR B CG2 1 
ATOM   2547 N  N   . TYR B 2 15  ? -27.307 -16.88  2.387   1    40.95  ? 185 TYR B N   1 
ATOM   2548 C  CA  . TYR B 2 15  ? -26.787 -16.249 3.586   1    38.42  ? 185 TYR B CA  1 
ATOM   2549 C  C   . TYR B 2 15  ? -26.612 -14.749 3.355   1    36.09  ? 185 TYR B C   1 
ATOM   2550 O  O   . TYR B 2 15  ? -26.971 -13.971 4.234   1    36.53  ? 185 TYR B O   1 
ATOM   2551 C  CB  . TYR B 2 15  ? -25.53  -16.972 4.063   1    37.38  ? 185 TYR B CB  1 
ATOM   2552 C  CG  . TYR B 2 15  ? -24.86  -16.316 5.262   1    41.54  ? 185 TYR B CG  1 
ATOM   2553 C  CD1 . TYR B 2 15  ? -25.448 -16.333 6.538   1    44.86  ? 185 TYR B CD1 1 
ATOM   2554 C  CD2 . TYR B 2 15  ? -23.64  -15.675 5.109   1    37.48  ? 185 TYR B CD2 1 
ATOM   2555 C  CE1 . TYR B 2 15  ? -24.849 -15.705 7.627   1    43.6   ? 185 TYR B CE1 1 
ATOM   2556 C  CE2 . TYR B 2 15  ? -23.027 -15.059 6.183   1    44.65  ? 185 TYR B CE2 1 
ATOM   2557 C  CZ  . TYR B 2 15  ? -23.626 -15.08  7.438   1    51.61  ? 185 TYR B CZ  1 
ATOM   2558 O  OH  . TYR B 2 15  ? -22.926 -14.474 8.434   1    55.4   ? 185 TYR B OH  1 
ATOM   2559 N  N   . LEU B 2 16  ? -26.106 -14.333 2.18    1    34.92  ? 186 LEU B N   1 
ATOM   2560 C  CA  . LEU B 2 16  ? -25.928 -12.915 1.927   1    35.99  ? 186 LEU B CA  1 
ATOM   2561 C  C   . LEU B 2 16  ? -27.269 -12.195 1.97    1    41.08  ? 186 LEU B C   1 
ATOM   2562 O  O   . LEU B 2 16  ? -27.34  -11.081 2.507   1    45.85  ? 186 LEU B O   1 
ATOM   2563 C  CB  . LEU B 2 16  ? -25.209 -12.677 0.614   1    37.36  ? 186 LEU B CB  1 
ATOM   2564 C  CG  . LEU B 2 16  ? -23.771 -13.189 0.57    1    39.41  ? 186 LEU B CG  1 
ATOM   2565 C  CD1 . LEU B 2 16  ? -23.192 -12.949 -0.821  1    34.93  ? 186 LEU B CD1 1 
ATOM   2566 C  CD2 . LEU B 2 16  ? -22.945 -12.513 1.674   1    35.73  ? 186 LEU B CD2 1 
ATOM   2567 N  N   . ARG B 2 17  ? -28.316 -12.857 1.444   1    38.07  ? 187 ARG B N   1 
ATOM   2568 C  CA  . ARG B 2 17  ? -29.669 -12.328 1.427   1    39.71  ? 187 ARG B CA  1 
ATOM   2569 C  C   . ARG B 2 17  ? -30.186 -12.056 2.84    1    43.55  ? 187 ARG B C   1 
ATOM   2570 O  O   . ARG B 2 17  ? -30.895 -11.076 3.075   1    48.9   ? 187 ARG B O   1 
ATOM   2571 C  CB  . ARG B 2 17  ? -30.603 -13.275 0.671   1    35.82  ? 187 ARG B CB  1 
ATOM   2572 C  CG  . ARG B 2 17  ? -30.321 -13.181 -0.83   1    40.62  ? 187 ARG B CG  1 
ATOM   2573 C  CD  . ARG B 2 17  ? -30.832 -11.912 -1.523  1    36.54  ? 187 ARG B CD  1 
ATOM   2574 N  NE  . ARG B 2 17  ? -32.283 -11.766 -1.369  1    37.03  ? 187 ARG B NE  1 
ATOM   2575 C  CZ  . ARG B 2 17  ? -33.177 -12.22  -2.237  1    39.02  ? 187 ARG B CZ  1 
ATOM   2576 N  NH1 . ARG B 2 17  ? -32.823 -12.694 -3.424  1    40.56  ? 187 ARG B NH1 1 
ATOM   2577 N  NH2 . ARG B 2 17  ? -34.444 -12.181 -1.917  1    36.12  ? 187 ARG B NH2 1 
ATOM   2578 N  N   . GLU B 2 18  ? -29.861 -12.949 3.768   1    42.22  ? 188 GLU B N   1 
ATOM   2579 C  CA  . GLU B 2 18  ? -30.277 -12.796 5.151   1    46.67  ? 188 GLU B CA  1 
ATOM   2580 C  C   . GLU B 2 18  ? -29.489 -11.635 5.77    1    44.22  ? 188 GLU B C   1 
ATOM   2581 O  O   . GLU B 2 18  ? -30.069 -10.725 6.338   1    51.12  ? 188 GLU B O   1 
ATOM   2582 C  CB  . GLU B 2 18  ? -30.202 -14.171 5.826   1    46.13  ? 188 GLU B CB  1 
ATOM   2583 C  CG  . GLU B 2 18  ? -30.358 -14.128 7.345   1    55.69  ? 188 GLU B CG  1 
ATOM   2584 C  CD  . GLU B 2 18  ? -30.118 -15.442 8.075   1    65.23  ? 188 GLU B CD  1 
ATOM   2585 O  OE1 . GLU B 2 18  ? -29.798 -16.462 7.398   1    69.15  ? 188 GLU B OE1 1 
ATOM   2586 O  OE2 . GLU B 2 18  ? -30.296 -15.429 9.317   1    60.95  ? 188 GLU B OE2 1 
ATOM   2587 N  N   . MET B 2 19  ? -28.177 -11.634 5.589   1    40.42  ? 189 MET B N   1 
ATOM   2588 C  CA  . MET B 2 19  ? -27.322 -10.634 6.197   1    45.63  ? 189 MET B CA  1 
ATOM   2589 C  C   . MET B 2 19  ? -27.596 -9.229  5.647   1    45.71  ? 189 MET B C   1 
ATOM   2590 O  O   . MET B 2 19  ? -27.522 -8.275  6.412   1    44.95  ? 189 MET B O   1 
ATOM   2591 C  CB  . MET B 2 19  ? -25.843 -11.026 6.086   1    39.74  ? 189 MET B CB  1 
ATOM   2592 C  CG  . MET B 2 19  ? -25.474 -12.249 6.899   1    47.17  ? 189 MET B CG  1 
ATOM   2593 S  SD  . MET B 2 19  ? -26.094 -12.387 8.599   1    54.26  ? 189 MET B SD  1 
ATOM   2594 C  CE  . MET B 2 19  ? -25.038 -11.128 9.328   1    66.66  ? 189 MET B CE  1 
ATOM   2595 N  N   . GLU B 2 20  ? -27.93  -9.077  4.357   1    39.05  ? 190 GLU B N   1 
ATOM   2596 C  CA  . GLU B 2 20  ? -28.083 -7.73   3.816   1    39.73  ? 190 GLU B CA  1 
ATOM   2597 C  C   . GLU B 2 20  ? -29.221 -7.01   4.522   1    39.69  ? 190 GLU B C   1 
ATOM   2598 O  O   . GLU B 2 20  ? -29.16  -5.796  4.714   1    43.3   ? 190 GLU B O   1 
ATOM   2599 C  CB  . GLU B 2 20  ? -28.237 -7.62   2.293   1    35.93  ? 190 GLU B CB  1 
ATOM   2600 C  CG  . GLU B 2 20  ? -29.541 -8.154  1.725   1    37.58  ? 190 GLU B CG  1 
ATOM   2601 C  CD  . GLU B 2 20  ? -29.621 -8.003  0.218   1    41.97  ? 190 GLU B CD  1 
ATOM   2602 O  OE1 . GLU B 2 20  ? -28.768 -7.317  -0.391  1    37.22  ? 190 GLU B OE1 1 
ATOM   2603 O  OE2 . GLU B 2 20  ? -30.554 -8.585  -0.358  1    40.33  ? 190 GLU B OE2 1 
ATOM   2604 N  N   . VAL B 2 21  ? -30.246 -7.786  4.9     1    42.33  ? 191 VAL B N   1 
ATOM   2605 C  CA  . VAL B 2 21  ? -31.359 -7.303  5.689   1    42.8   ? 191 VAL B CA  1 
ATOM   2606 C  C   . VAL B 2 21  ? -30.899 -6.895  7.095   1    46.8   ? 191 VAL B C   1 
ATOM   2607 O  O   . VAL B 2 21  ? -31.34  -5.879  7.6     1    54.95  ? 191 VAL B O   1 
ATOM   2608 C  CB  . VAL B 2 21  ? -32.51  -8.333  5.703   1    42.4   ? 191 VAL B CB  1 
ATOM   2609 C  CG1 . VAL B 2 21  ? -33.673 -7.927  6.615   1    35.47  ? 191 VAL B CG1 1 
ATOM   2610 C  CG2 . VAL B 2 21  ? -33.04  -8.634  4.298   1    37.53  ? 191 VAL B CG2 1 
ATOM   2611 N  N   . LYS B 2 22  ? -29.985 -7.623  7.717   1    51.15  ? 192 LYS B N   1 
ATOM   2612 C  CA  . LYS B 2 22  ? -29.571 -7.28   9.098   1    57.47  ? 192 LYS B CA  1 
ATOM   2613 C  C   . LYS B 2 22  ? -28.615 -6.08   9.074   1    61.65  ? 192 LYS B C   1 
ATOM   2614 O  O   . LYS B 2 22  ? -28.687 -5.251  9.994   1    67.61  ? 192 LYS B O   1 
ATOM   2615 C  CB  . LYS B 2 22  ? -28.918 -8.527  9.696   1    63.72  ? 192 LYS B CB  1 
ATOM   2616 C  CG  . LYS B 2 22  ? -28.013 -8.306  10.896  1    79.67  ? 192 LYS B CG  1 
ATOM   2617 C  CD  . LYS B 2 22  ? -26.541 -8.267  10.514  1    93.31  ? 192 LYS B CD  1 
ATOM   2618 C  CE  . LYS B 2 22  ? -25.632 -8.008  11.666  1    110.03 ? 192 LYS B CE  1 
ATOM   2619 N  NZ  . LYS B 2 22  ? -24.332 -8.637  11.428  1    124.75 ? 192 LYS B NZ  1 
ATOM   2620 N  N   . CYS B 2 23  ? -27.775 -5.981  8.052   1    60.14  ? 193 CYS B N   1 
ATOM   2621 C  CA  . CYS B 2 23  ? -26.772 -4.928  7.912   1    57.76  ? 193 CYS B CA  1 
ATOM   2622 C  C   . CYS B 2 23  ? -27.349 -3.668  7.251   1    58.14  ? 193 CYS B C   1 
ATOM   2623 O  O   . CYS B 2 23  ? -26.596 -2.783  6.83    1    60.28  ? 193 CYS B O   1 
ATOM   2624 C  CB  . CYS B 2 23  ? -25.586 -5.425  7.057   1    49.69  ? 193 CYS B CB  1 
ATOM   2625 S  SG  . CYS B 2 23  ? -24.428 -6.558  7.915   1    59.76  ? 193 CYS B SG  1 
ATOM   2626 N  N   . LYS B 2 24  ? -28.673 -3.593  7.087   1    48.58  ? 194 LYS B N   1 
ATOM   2627 C  CA  . LYS B 2 24  ? -29.24  -2.513  6.29    1    48.92  ? 194 LYS B CA  1 
ATOM   2628 C  C   . LYS B 2 24  ? -29.282 -1.216  7.113   1    52.23  ? 194 LYS B C   1 
ATOM   2629 O  O   . LYS B 2 24  ? -29.631 -1.22   8.294   1    50.27  ? 194 LYS B O   1 
ATOM   2630 C  CB  . LYS B 2 24  ? -30.661 -2.843  5.82    1    51.73  ? 194 LYS B CB  1 
ATOM   2631 C  CG  . LYS B 2 24  ? -31.128 -2.002  4.66    1    54.79  ? 194 LYS B CG  1 
ATOM   2632 C  CD  . LYS B 2 24  ? -32.638 -1.991  4.443   1    60.43  ? 194 LYS B CD  1 
ATOM   2633 C  CE  . LYS B 2 24  ? -33     -1.146  3.231   1    67.88  ? 194 LYS B CE  1 
ATOM   2634 N  NZ  . LYS B 2 24  ? -34.38  -1.375  2.777   1    73.42  ? 194 LYS B NZ  1 
ATOM   2635 N  N   . PRO B 2 25  ? -28.949 -0.049  6.513   1    52.96  ? 195 PRO B N   1 
ATOM   2636 C  CA  . PRO B 2 25  ? -29.107 1.242   7.184   1    49.89  ? 195 PRO B CA  1 
ATOM   2637 C  C   . PRO B 2 25  ? -30.578 1.6     7.3     1    46.58  ? 195 PRO B C   1 
ATOM   2638 O  O   . PRO B 2 25  ? -31.387 1.041   6.581   1    53.88  ? 195 PRO B O   1 
ATOM   2639 C  CB  . PRO B 2 25  ? -28.367 2.248   6.249   1    51.89  ? 195 PRO B CB  1 
ATOM   2640 C  CG  . PRO B 2 25  ? -27.578 1.391   5.263   1    51.1   ? 195 PRO B CG  1 
ATOM   2641 C  CD  . PRO B 2 25  ? -28.345 0.086   5.17    1    51.88  ? 195 PRO B CD  1 
ATOM   2642 N  N   . LYS B 2 26  ? -30.889 2.532   8.203   1    43.85  ? 196 LYS B N   1 
ATOM   2643 C  CA  . LYS B 2 26  ? -32.192 3.173   8.289   1    51.47  ? 196 LYS B CA  1 
ATOM   2644 C  C   . LYS B 2 26  ? -32.44  3.986   7.017   1    53.95  ? 196 LYS B C   1 
ATOM   2645 O  O   . LYS B 2 26  ? -31.636 4.831   6.667   1    56.65  ? 196 LYS B O   1 
ATOM   2646 C  CB  . LYS B 2 26  ? -32.284 4.108   9.503   1    57.07  ? 196 LYS B CB  1 
ATOM   2647 C  CG  . LYS B 2 26  ? -33.013 3.568   10.728  1    73.49  ? 196 LYS B CG  1 
ATOM   2648 C  CD  . LYS B 2 26  ? -32.785 4.289   12.062  1    80.84  ? 196 LYS B CD  1 
ATOM   2649 C  CE  . LYS B 2 26  ? -32.564 5.79    11.986  1    83.51  ? 196 LYS B CE  1 
ATOM   2650 N  NZ  . LYS B 2 26  ? -33.703 6.615   11.556  1    76.89  ? 196 LYS B NZ  1 
ATOM   2651 N  N   . VAL B 2 27  ? -33.56  3.756   6.338   1    52.66  ? 197 VAL B N   1 
ATOM   2652 C  CA  . VAL B 2 27  ? -33.81  4.435   5.031   1    52.95  ? 197 VAL B CA  1 
ATOM   2653 C  C   . VAL B 2 27  ? -33.901 5.959   5.21    1    55.93  ? 197 VAL B C   1 
ATOM   2654 O  O   . VAL B 2 27  ? -33.457 6.687   4.311   1    58.49  ? 197 VAL B O   1 
ATOM   2655 C  CB  . VAL B 2 27  ? -35.065 3.866   4.345   1    57.43  ? 197 VAL B CB  1 
ATOM   2656 C  CG1 . VAL B 2 27  ? -35.376 4.572   3.033   1    55.15  ? 197 VAL B CG1 1 
ATOM   2657 C  CG2 . VAL B 2 27  ? -34.945 2.365   4.121   1    62.7   ? 197 VAL B CG2 1 
ATOM   2658 N  N   . GLY B 2 28  ? -34.441 6.43    6.324   1    57.4   ? 198 GLY B N   1 
ATOM   2659 C  CA  . GLY B 2 28  ? -34.617 7.883   6.475   1    71.1   ? 198 GLY B CA  1 
ATOM   2660 C  C   . GLY B 2 28  ? -33.814 8.45    7.62    1    80.31  ? 198 GLY B C   1 
ATOM   2661 O  O   . GLY B 2 28  ? -34.418 9.11    8.485   1    88     ? 198 GLY B O   1 
ATOM   2662 N  N   . TYR B 2 29  ? -32.501 8.238   7.614   1    67.2   ? 199 TYR B N   1 
ATOM   2663 C  CA  . TYR B 2 29  ? -31.661 8.689   8.753   1    58.95  ? 199 TYR B CA  1 
ATOM   2664 C  C   . TYR B 2 29  ? -31.27  10.131  8.53    1    57.39  ? 199 TYR B C   1 
ATOM   2665 O  O   . TYR B 2 29  ? -31.033 10.846  9.512   1    49.31  ? 199 TYR B O   1 
ATOM   2666 C  CB  . TYR B 2 29  ? -30.474 7.725   8.908   1    50.68  ? 199 TYR B CB  1 
ATOM   2667 C  CG  . TYR B 2 29  ? -29.264 7.847   7.99    1    43.69  ? 199 TYR B CG  1 
ATOM   2668 C  CD1 . TYR B 2 29  ? -28.438 8.963   8.018   1    47.72  ? 199 TYR B CD1 1 
ATOM   2669 C  CD2 . TYR B 2 29  ? -28.916 6.812   7.137   1    45.08  ? 199 TYR B CD2 1 
ATOM   2670 C  CE1 . TYR B 2 29  ? -27.339 9.07    7.186   1    46.9   ? 199 TYR B CE1 1 
ATOM   2671 C  CE2 . TYR B 2 29  ? -27.809 6.898   6.311   1    47.89  ? 199 TYR B CE2 1 
ATOM   2672 C  CZ  . TYR B 2 29  ? -27.018 8.03    6.336   1    47.62  ? 199 TYR B CZ  1 
ATOM   2673 O  OH  . TYR B 2 29  ? -25.928 8.125   5.527   1    46.31  ? 199 TYR B OH  1 
ATOM   2674 N  N   . MET B 2 30  ? -31.206 10.546  7.268   1    53.14  ? 200 MET B N   1 
ATOM   2675 C  CA  . MET B 2 30  ? -30.701 11.905  6.972   1    52.1   ? 200 MET B CA  1 
ATOM   2676 C  C   . MET B 2 30  ? -31.67  12.95   7.517   1    57.3   ? 200 MET B C   1 
ATOM   2677 O  O   . MET B 2 30  ? -31.192 13.995  7.982   1    57     ? 200 MET B O   1 
ATOM   2678 C  CB  . MET B 2 30  ? -30.498 12.112  5.472   1    51.71  ? 200 MET B CB  1 
ATOM   2679 C  CG  . MET B 2 30  ? -29.448 13.145  5.142   1    54.39  ? 200 MET B CG  1 
ATOM   2680 S  SD  . MET B 2 30  ? -27.936 12.928  6.096   1    54.98  ? 200 MET B SD  1 
ATOM   2681 C  CE  . MET B 2 30  ? -26.946 11.993  4.925   1    54.22  ? 200 MET B CE  1 
ATOM   2682 N  N   . LYS B 2 31  ? -32.971 12.678  7.481   1    63.75  ? 201 LYS B N   1 
ATOM   2683 C  CA  . LYS B 2 31  ? -33.853 13.739  7.948   1    63.33  ? 201 LYS B CA  1 
ATOM   2684 C  C   . LYS B 2 31  ? -33.777 13.835  9.467   1    60.7   ? 201 LYS B C   1 
ATOM   2685 O  O   . LYS B 2 31  ? -34.085 14.877  10.039  1    64.07  ? 201 LYS B O   1 
ATOM   2686 C  CB  . LYS B 2 31  ? -35.244 13.732  7.298   1    66.06  ? 201 LYS B CB  1 
ATOM   2687 C  CG  . LYS B 2 31  ? -35.905 12.39   7.05    1    76.01  ? 201 LYS B CG  1 
ATOM   2688 C  CD  . LYS B 2 31  ? -37.266 12.537  6.36    1    89.37  ? 201 LYS B CD  1 
ATOM   2689 C  CE  . LYS B 2 31  ? -37.615 11.572  5.234   1    88.82  ? 201 LYS B CE  1 
ATOM   2690 N  NZ  . LYS B 2 31  ? -37.489 10.125  5.489   1    78.76  ? 201 LYS B NZ  1 
ATOM   2691 N  N   . LYS B 2 32  ? -33.271 12.782  10.105  1    64.16  ? 202 LYS B N   1 
ATOM   2692 C  CA  . LYS B 2 32  ? -33.031 12.803  11.548  1    67.52  ? 202 LYS B CA  1 
ATOM   2693 C  C   . LYS B 2 32  ? -31.612 13.268  11.889  1    66.61  ? 202 LYS B C   1 
ATOM   2694 O  O   . LYS B 2 32  ? -31.265 13.316  13.059  1    67.93  ? 202 LYS B O   1 
ATOM   2695 C  CB  . LYS B 2 32  ? -33.28  11.421  12.159  1    68.44  ? 202 LYS B CB  1 
ATOM   2696 C  CG  . LYS B 2 32  ? -34.764 11.087  12.377  1    85.02  ? 202 LYS B CG  1 
ATOM   2697 C  CD  . LYS B 2 32  ? -35.135 9.671   11.927  1    95.2   ? 202 LYS B CD  1 
ATOM   2698 C  CE  . LYS B 2 32  ? -35.958 8.987   12.99   1    96.79  ? 202 LYS B CE  1 
ATOM   2699 N  NZ  . LYS B 2 32  ? -36.443 7.631   12.722  1    81.71  ? 202 LYS B NZ  1 
ATOM   2700 N  N   . GLN B 2 33  ? -30.776 13.578  10.884  1    60.78  ? 203 GLN B N   1 
ATOM   2701 C  CA  . GLN B 2 33  ? -29.466 14.181  11.141  1    57.43  ? 203 GLN B CA  1 
ATOM   2702 C  C   . GLN B 2 33  ? -29.585 15.709  11.075  1    55.28  ? 203 GLN B C   1 
ATOM   2703 O  O   . GLN B 2 33  ? -29.821 16.287  10.013  1    54.63  ? 203 GLN B O   1 
ATOM   2704 C  CB  . GLN B 2 33  ? -28.385 13.683  10.172  1    51.46  ? 203 GLN B CB  1 
ATOM   2705 C  CG  . GLN B 2 33  ? -27.95  12.236  10.377  1    47.17  ? 203 GLN B CG  1 
ATOM   2706 C  CD  . GLN B 2 33  ? -26.79  12.028  11.329  1    44.98  ? 203 GLN B CD  1 
ATOM   2707 O  OE1 . GLN B 2 33  ? -26.117 12.962  11.752  1    44.41  ? 203 GLN B OE1 1 
ATOM   2708 N  NE2 . GLN B 2 33  ? -26.511 10.776  11.65   1    44.48  ? 203 GLN B NE2 1 
ATOM   2709 N  N   . PRO B 2 34  ? -29.44  16.433  12.204  1    57.56  ? 204 PRO B N   1 
ATOM   2710 C  CA  . PRO B 2 34  ? -29.639 17.886  12.205  1    57.83  ? 204 PRO B CA  1 
ATOM   2711 C  C   . PRO B 2 34  ? -28.71  18.698  11.303  1    55.16  ? 204 PRO B C   1 
ATOM   2712 O  O   . PRO B 2 34  ? -29.113 19.749  10.826  1    58.31  ? 204 PRO B O   1 
ATOM   2713 C  CB  . PRO B 2 34  ? -29.463 18.269  13.697  1    55.28  ? 204 PRO B CB  1 
ATOM   2714 C  CG  . PRO B 2 34  ? -28.588 17.17   14.259  1    53.1   ? 204 PRO B CG  1 
ATOM   2715 C  CD  . PRO B 2 34  ? -29.083 15.913  13.537  1    54.91  ? 204 PRO B CD  1 
ATOM   2716 N  N   . ASP B 2 35  ? -27.479 18.216  11.074  1    54.78  ? 205 ASP B N   1 
ATOM   2717 C  CA  . ASP B 2 35  ? -26.411 19.094  10.611  1    55.12  ? 205 ASP B CA  1 
ATOM   2718 C  C   . ASP B 2 35  ? -25.77  18.634  9.302   1    55.31  ? 205 ASP B C   1 
ATOM   2719 O  O   . ASP B 2 35  ? -24.949 19.369  8.746   1    58.23  ? 205 ASP B O   1 
ATOM   2720 C  CB  . ASP B 2 35  ? -25.339 19.304  11.665  1    54.57  ? 205 ASP B CB  1 
ATOM   2721 C  CG  . ASP B 2 35  ? -24.552 20.58   11.428  1    60.62  ? 205 ASP B CG  1 
ATOM   2722 O  OD1 . ASP B 2 35  ? -25.206 21.65   11.448  1    67.41  ? 205 ASP B OD1 1 
ATOM   2723 O  OD2 . ASP B 2 35  ? -23.317 20.498  11.191  1    56.53  ? 205 ASP B OD2 1 
ATOM   2724 N  N   . ILE B 2 36  ? -26.136 17.431  8.838   1    53.82  ? 206 ILE B N   1 
ATOM   2725 C  CA  . ILE B 2 36  ? -25.66  16.873  7.584   1    53.96  ? 206 ILE B CA  1 
ATOM   2726 C  C   . ILE B 2 36  ? -26.839 16.486  6.676   1    57.08  ? 206 ILE B C   1 
ATOM   2727 O  O   . ILE B 2 36  ? -27.991 16.374  7.122   1    54.47  ? 206 ILE B O   1 
ATOM   2728 C  CB  . ILE B 2 36  ? -24.668 15.713  7.826   1    54.68  ? 206 ILE B CB  1 
ATOM   2729 C  CG1 . ILE B 2 36  ? -25.284 14.533  8.505   1    50.39  ? 206 ILE B CG1 1 
ATOM   2730 C  CG2 . ILE B 2 36  ? -23.412 16.185  8.567   1    56.2   ? 206 ILE B CG2 1 
ATOM   2731 C  CD1 . ILE B 2 36  ? -24.28  13.407  8.713   1    53.68  ? 206 ILE B CD1 1 
ATOM   2732 N  N   . THR B 2 37  ? -26.536 16.343  5.365   1    52.28  ? 207 THR B N   1 
ATOM   2733 C  CA  . THR B 2 37  ? -27.535 16.232  4.308   1    49.13  ? 207 THR B CA  1 
ATOM   2734 C  C   . THR B 2 37  ? -27.052 15.218  3.284   1    51.01  ? 207 THR B C   1 
ATOM   2735 O  O   . THR B 2 37  ? -25.867 14.885  3.239   1    52.99  ? 207 THR B O   1 
ATOM   2736 C  CB  . THR B 2 37  ? -27.714 17.554  3.561   1    49.77  ? 207 THR B CB  1 
ATOM   2737 O  OG1 . THR B 2 37  ? -26.45  17.804  2.942   1    51.09  ? 207 THR B OG1 1 
ATOM   2738 C  CG2 . THR B 2 37  ? -28.09  18.728  4.442   1    43.91  ? 207 THR B CG2 1 
ATOM   2739 N  N   . ASN B 2 38  ? -27.979 14.798  2.419   1    51.26  ? 208 ASN B N   1 
ATOM   2740 C  CA  . ASN B 2 38  ? -27.67  13.928  1.301   1    50.23  ? 208 ASN B CA  1 
ATOM   2741 C  C   . ASN B 2 38  ? -26.51  14.496  0.483   1    49.41  ? 208 ASN B C   1 
ATOM   2742 O  O   . ASN B 2 38  ? -25.621 13.761  0.044   1    45.82  ? 208 ASN B O   1 
ATOM   2743 C  CB  . ASN B 2 38  ? -28.895 13.682  0.433   1    50.47  ? 208 ASN B CB  1 
ATOM   2744 C  CG  . ASN B 2 38  ? -29.939 12.903  1.196   1    55.49  ? 208 ASN B CG  1 
ATOM   2745 O  OD1 . ASN B 2 38  ? -29.584 12.046  2.015   1    56.65  ? 208 ASN B OD1 1 
ATOM   2746 N  ND2 . ASN B 2 38  ? -31.209 13.175  0.93    1    58.08  ? 208 ASN B ND2 1 
ATOM   2747 N  N   . SER B 2 39  ? -26.495 15.82   0.348   1    48.48  ? 209 SER B N   1 
ATOM   2748 C  CA  . SER B 2 39  ? -25.508 16.474  -0.496  1    52.69  ? 209 SER B CA  1 
ATOM   2749 C  C   . SER B 2 39  ? -24.101 16.321  0.083   1    50.52  ? 209 SER B C   1 
ATOM   2750 O  O   . SER B 2 39  ? -23.152 16.062  -0.662  1    49.88  ? 209 SER B O   1 
ATOM   2751 C  CB  . SER B 2 39  ? -25.871 17.912  -0.728  1    53.16  ? 209 SER B CB  1 
ATOM   2752 O  OG  . SER B 2 39  ? -24.736 18.613  -1.196  1    57.64  ? 209 SER B OG  1 
ATOM   2753 N  N   . MET B 2 40  ? -23.991 16.475  1.414   1    50.24  ? 210 MET B N   1 
ATOM   2754 C  CA  . MET B 2 40  ? -22.724 16.336  2.114   1    49.22  ? 210 MET B CA  1 
ATOM   2755 C  C   . MET B 2 40  ? -22.226 14.898  2.065   1    47.73  ? 210 MET B C   1 
ATOM   2756 O  O   . MET B 2 40  ? -21.03  14.672  1.915   1    51.06  ? 210 MET B O   1 
ATOM   2757 C  CB  . MET B 2 40  ? -22.83  16.798  3.566   1    47.57  ? 210 MET B CB  1 
ATOM   2758 C  CG  . MET B 2 40  ? -23.068 18.283  3.681   1    48.08  ? 210 MET B CG  1 
ATOM   2759 S  SD  . MET B 2 40  ? -23.271 18.635  5.437   1    53.98  ? 210 MET B SD  1 
ATOM   2760 C  CE  . MET B 2 40  ? -24.234 20.16   5.387   1    49.71  ? 210 MET B CE  1 
ATOM   2761 N  N   . ARG B 2 41  ? -23.156 13.94   2.162   1    46.66  ? 211 ARG B N   1 
ATOM   2762 C  CA  . ARG B 2 41  ? -22.812 12.523  2.143   1    44.3   ? 211 ARG B CA  1 
ATOM   2763 C  C   . ARG B 2 41  ? -22.252 12.2    0.762   1    46.42  ? 211 ARG B C   1 
ATOM   2764 O  O   . ARG B 2 41  ? -21.348 11.378  0.609   1    52.66  ? 211 ARG B O   1 
ATOM   2765 C  CB  . ARG B 2 41  ? -24.057 11.689  2.484   1    43.41  ? 211 ARG B CB  1 
ATOM   2766 C  CG  . ARG B 2 41  ? -23.834 10.184  2.504   1    43.15  ? 211 ARG B CG  1 
ATOM   2767 C  CD  . ARG B 2 41  ? -25.14  9.393   2.49    1    42.94  ? 211 ARG B CD  1 
ATOM   2768 N  NE  . ARG B 2 41  ? -24.941 7.975   2.18    1    41.83  ? 211 ARG B NE  1 
ATOM   2769 C  CZ  . ARG B 2 41  ? -24.638 7.491   0.972   1    42.5   ? 211 ARG B CZ  1 
ATOM   2770 N  NH1 . ARG B 2 41  ? -24.617 8.302   -0.072  1    41.39  ? 211 ARG B NH1 1 
ATOM   2771 N  NH2 . ARG B 2 41  ? -24.323 6.2     0.811   1    39.24  ? 211 ARG B NH2 1 
ATOM   2772 N  N   . ALA B 2 42  ? -22.829 12.842  -0.254  1    45.76  ? 212 ALA B N   1 
ATOM   2773 C  CA  . ALA B 2 42  ? -22.456 12.599  -1.632  1    44.73  ? 212 ALA B CA  1 
ATOM   2774 C  C   . ALA B 2 42  ? -21.017 13.063  -1.829  1    47.7   ? 212 ALA B C   1 
ATOM   2775 O  O   . ALA B 2 42  ? -20.206 12.346  -2.422  1    47.9   ? 212 ALA B O   1 
ATOM   2776 C  CB  . ALA B 2 42  ? -23.408 13.352  -2.532  1    47.05  ? 212 ALA B CB  1 
ATOM   2777 N  N   . ILE B 2 43  ? -20.701 14.247  -1.279  1    46.93  ? 213 ILE B N   1 
ATOM   2778 C  CA  . ILE B 2 43  ? -19.353 14.777  -1.35   1    46.88  ? 213 ILE B CA  1 
ATOM   2779 C  C   . ILE B 2 43  ? -18.356 13.813  -0.68   1    47.68  ? 213 ILE B C   1 
ATOM   2780 O  O   . ILE B 2 43  ? -17.249 13.592  -1.207  1    44.98  ? 213 ILE B O   1 
ATOM   2781 C  CB  . ILE B 2 43  ? -19.327 16.191  -0.748  1    49.79  ? 213 ILE B CB  1 
ATOM   2782 C  CG1 . ILE B 2 43  ? -20.173 17.19   -1.589  1    50.78  ? 213 ILE B CG1 1 
ATOM   2783 C  CG2 . ILE B 2 43  ? -17.882 16.678  -0.552  1    46     ? 213 ILE B CG2 1 
ATOM   2784 C  CD1 . ILE B 2 43  ? -20.3   18.586  -0.977  1    44.18  ? 213 ILE B CD1 1 
ATOM   2785 N  N   . LEU B 2 44  ? -18.748 13.235  0.472   1    41.91  ? 214 LEU B N   1 
ATOM   2786 C  CA  . LEU B 2 44  ? -17.894 12.31   1.21    1    44.5   ? 214 LEU B CA  1 
ATOM   2787 C  C   . LEU B 2 44  ? -17.653 11.032  0.393   1    45.78  ? 214 LEU B C   1 
ATOM   2788 O  O   . LEU B 2 44  ? -16.512 10.607  0.174   1    39.13  ? 214 LEU B O   1 
ATOM   2789 C  CB  . LEU B 2 44  ? -18.494 12.022  2.584   1    41.06  ? 214 LEU B CB  1 
ATOM   2790 C  CG  . LEU B 2 44  ? -17.842 10.902  3.402   1    43.8   ? 214 LEU B CG  1 
ATOM   2791 C  CD1 . LEU B 2 44  ? -16.513 11.348  3.994   1    44.51  ? 214 LEU B CD1 1 
ATOM   2792 C  CD2 . LEU B 2 44  ? -18.755 10.4    4.524   1    41.33  ? 214 LEU B CD2 1 
ATOM   2793 N  N   . VAL B 2 45  ? -18.741 10.451  -0.117  1    42.88  ? 215 VAL B N   1 
ATOM   2794 C  CA  . VAL B 2 45  ? -18.578 9.22    -0.859  1    46.81  ? 215 VAL B CA  1 
ATOM   2795 C  C   . VAL B 2 45  ? -17.682 9.468   -2.071  1    51.88  ? 215 VAL B C   1 
ATOM   2796 O  O   . VAL B 2 45  ? -16.749 8.699   -2.316  1    57.99  ? 215 VAL B O   1 
ATOM   2797 C  CB  . VAL B 2 45  ? -19.915 8.551   -1.216  1    46.18  ? 215 VAL B CB  1 
ATOM   2798 C  CG1 . VAL B 2 45  ? -19.666 7.277   -2.002  1    41.78  ? 215 VAL B CG1 1 
ATOM   2799 C  CG2 . VAL B 2 45  ? -20.742 8.243   0.042   1    43.37  ? 215 VAL B CG2 1 
ATOM   2800 N  N   . ASP B 2 46  ? -17.955 10.551  -2.815  1    49.97  ? 216 ASP B N   1 
ATOM   2801 C  CA  . ASP B 2 46  ? -17.197 10.874  -4.013  1    44.3   ? 216 ASP B CA  1 
ATOM   2802 C  C   . ASP B 2 46  ? -15.709 10.931  -3.667  1    46.21  ? 216 ASP B C   1 
ATOM   2803 O  O   . ASP B 2 46  ? -14.864 10.441  -4.433  1    51.78  ? 216 ASP B O   1 
ATOM   2804 C  CB  . ASP B 2 46  ? -17.642 12.2    -4.609  1    46.78  ? 216 ASP B CB  1 
ATOM   2805 C  CG  . ASP B 2 46  ? -16.962 12.557  -5.917  1    50.3   ? 216 ASP B CG  1 
ATOM   2806 O  OD1 . ASP B 2 46  ? -17.342 11.963  -6.944  1    54.39  ? 216 ASP B OD1 1 
ATOM   2807 O  OD2 . ASP B 2 46  ? -15.997 13.348  -5.889  1    50.4   ? 216 ASP B OD2 1 
ATOM   2808 N  N   . TRP B 2 47  ? -15.404 11.55   -2.517  1    42.92  ? 217 TRP B N   1 
ATOM   2809 C  CA  . TRP B 2 47  ? -14.043 11.676  -2.016  1    44.75  ? 217 TRP B CA  1 
ATOM   2810 C  C   . TRP B 2 47  ? -13.453 10.296  -1.691  1    51.25  ? 217 TRP B C   1 
ATOM   2811 O  O   . TRP B 2 47  ? -12.281 10.02   -1.996  1    55.58  ? 217 TRP B O   1 
ATOM   2812 C  CB  . TRP B 2 47  ? -14.031 12.61   -0.799  1    43.52  ? 217 TRP B CB  1 
ATOM   2813 C  CG  . TRP B 2 47  ? -12.718 12.658  -0.083  1    44.11  ? 217 TRP B CG  1 
ATOM   2814 C  CD1 . TRP B 2 47  ? -11.594 13.291  -0.52   1    48.98  ? 217 TRP B CD1 1 
ATOM   2815 C  CD2 . TRP B 2 47  ? -12.367 12.048  1.173   1    43.3   ? 217 TRP B CD2 1 
ATOM   2816 N  NE1 . TRP B 2 47  ? -10.567 13.128  0.371   1    45.37  ? 217 TRP B NE1 1 
ATOM   2817 C  CE2 . TRP B 2 47  ? -11.017 12.376  1.423   1    45.59  ? 217 TRP B CE2 1 
ATOM   2818 C  CE3 . TRP B 2 47  ? -13.057 11.284  2.113   1    45.52  ? 217 TRP B CE3 1 
ATOM   2819 C  CZ2 . TRP B 2 47  ? -10.343 11.962  2.566   1    46.5   ? 217 TRP B CZ2 1 
ATOM   2820 C  CZ3 . TRP B 2 47  ? -12.387 10.864  3.244   1    45.6   ? 217 TRP B CZ3 1 
ATOM   2821 C  CH2 . TRP B 2 47  ? -11.053 11.203  3.466   1    49.48  ? 217 TRP B CH2 1 
ATOM   2822 N  N   . LEU B 2 48  ? -14.256 9.412   -1.08   1    48.37  ? 218 LEU B N   1 
ATOM   2823 C  CA  . LEU B 2 48  ? -13.771 8.078   -0.769  1    45.92  ? 218 LEU B CA  1 
ATOM   2824 C  C   . LEU B 2 48  ? -13.51  7.321   -2.068  1    50.24  ? 218 LEU B C   1 
ATOM   2825 O  O   . LEU B 2 48  ? -12.655 6.453   -2.081  1    55.4   ? 218 LEU B O   1 
ATOM   2826 C  CB  . LEU B 2 48  ? -14.777 7.323   0.091   1    46.61  ? 218 LEU B CB  1 
ATOM   2827 C  CG  . LEU B 2 48  ? -14.969 7.834   1.519   1    45.85  ? 218 LEU B CG  1 
ATOM   2828 C  CD1 . LEU B 2 48  ? -16.095 7.061   2.182   1    41.78  ? 218 LEU B CD1 1 
ATOM   2829 C  CD2 . LEU B 2 48  ? -13.655 7.709   2.273   1    43.58  ? 218 LEU B CD2 1 
ATOM   2830 N  N   . VAL B 2 49  ? -14.236 7.645   -3.149  1    44.46  ? 219 VAL B N   1 
ATOM   2831 C  CA  . VAL B 2 49  ? -13.957 7.066   -4.455  1    42.45  ? 219 VAL B CA  1 
ATOM   2832 C  C   . VAL B 2 49  ? -12.561 7.497   -4.909  1    47.87  ? 219 VAL B C   1 
ATOM   2833 O  O   . VAL B 2 49  ? -11.777 6.677   -5.368  1    43.87  ? 219 VAL B O   1 
ATOM   2834 C  CB  . VAL B 2 49  ? -15.025 7.448   -5.489  1    41.31  ? 219 VAL B CB  1 
ATOM   2835 C  CG1 . VAL B 2 49  ? -14.619 7.064   -6.902  1    39.08  ? 219 VAL B CG1 1 
ATOM   2836 C  CG2 . VAL B 2 49  ? -16.388 6.857   -5.13   1    41.97  ? 219 VAL B CG2 1 
ATOM   2837 N  N   . GLU B 2 50  ? -12.227 8.779   -4.72   1    49.89  ? 220 GLU B N   1 
ATOM   2838 C  CA  . GLU B 2 50  ? -10.898 9.245   -5.062  1    54.84  ? 220 GLU B CA  1 
ATOM   2839 C  C   . GLU B 2 50  ? -9.817  8.604   -4.183  1    57.4   ? 220 GLU B C   1 
ATOM   2840 O  O   . GLU B 2 50  ? -8.716  8.351   -4.673  1    57.34  ? 220 GLU B O   1 
ATOM   2841 C  CB  . GLU B 2 50  ? -10.809 10.763  -4.959  1    57.27  ? 220 GLU B CB  1 
ATOM   2842 C  CG  . GLU B 2 50  ? -11.273 11.469  -6.223  1    67.35  ? 220 GLU B CG  1 
ATOM   2843 C  CD  . GLU B 2 50  ? -11.057 12.961  -6.096  1    74.52  ? 220 GLU B CD  1 
ATOM   2844 O  OE1 . GLU B 2 50  ? -11.03  13.634  -7.171  1    80.92  ? 220 GLU B OE1 1 
ATOM   2845 O  OE2 . GLU B 2 50  ? -10.904 13.418  -4.92   1    71.11  ? 220 GLU B OE2 1 
ATOM   2846 N  N   . VAL B 2 51  ? -10.1   8.361   -2.896  1    49.72  ? 221 VAL B N   1 
ATOM   2847 C  CA  . VAL B 2 51  ? -9.087  7.784   -2.026  1    47.34  ? 221 VAL B CA  1 
ATOM   2848 C  C   . VAL B 2 51  ? -8.764  6.358   -2.482  1    47.55  ? 221 VAL B C   1 
ATOM   2849 O  O   . VAL B 2 51  ? -7.588  5.977   -2.547  1    49.37  ? 221 VAL B O   1 
ATOM   2850 C  CB  . VAL B 2 51  ? -9.515  7.858   -0.545  1    44.9   ? 221 VAL B CB  1 
ATOM   2851 C  CG1 . VAL B 2 51  ? -8.621  7.027   0.38    1    41.03  ? 221 VAL B CG1 1 
ATOM   2852 C  CG2 . VAL B 2 51  ? -9.632  9.298   -0.071  1    40.58  ? 221 VAL B CG2 1 
ATOM   2853 N  N   . GLY B 2 52  ? -9.805  5.564   -2.772  1    45.22  ? 222 GLY B N   1 
ATOM   2854 C  CA  . GLY B 2 52  ? -9.625  4.2     -3.243  1    46.48  ? 222 GLY B CA  1 
ATOM   2855 C  C   . GLY B 2 52  ? -8.817  4.171   -4.536  1    52.61  ? 222 GLY B C   1 
ATOM   2856 O  O   . GLY B 2 52  ? -8.017  3.258   -4.732  1    55.06  ? 222 GLY B O   1 
ATOM   2857 N  N   . GLU B 2 53  ? -9.027  5.185   -5.392  1    55.95  ? 223 GLU B N   1 
ATOM   2858 C  CA  . GLU B 2 53  ? -8.312  5.333   -6.657  1    62.9   ? 223 GLU B CA  1 
ATOM   2859 C  C   . GLU B 2 53  ? -6.839  5.628   -6.389  1    60.63  ? 223 GLU B C   1 
ATOM   2860 O  O   . GLU B 2 53  ? -5.955  4.991   -6.958  1    61.74  ? 223 GLU B O   1 
ATOM   2861 C  CB  . GLU B 2 53  ? -8.935  6.453   -7.499  1    66.44  ? 223 GLU B CB  1 
ATOM   2862 C  CG  . GLU B 2 53  ? -8.934  6.173   -8.995  1    85.07  ? 223 GLU B CG  1 
ATOM   2863 C  CD  . GLU B 2 53  ? -9.591  4.858   -9.389  1    100.03 ? 223 GLU B CD  1 
ATOM   2864 O  OE1 . GLU B 2 53  ? -10.235 4.236   -8.501  1    87.73  ? 223 GLU B OE1 1 
ATOM   2865 O  OE2 . GLU B 2 53  ? -9.441  4.441   -10.575 1    127.81 ? 223 GLU B OE2 1 
ATOM   2866 N  N   . GLU B 2 54  ? -6.602  6.604   -5.506  1    61.23  ? 224 GLU B N   1 
ATOM   2867 C  CA  . GLU B 2 54  ? -5.275  7.069   -5.157  1    59.97  ? 224 GLU B CA  1 
ATOM   2868 C  C   . GLU B 2 54  ? -4.473  5.934   -4.525  1    62.39  ? 224 GLU B C   1 
ATOM   2869 O  O   . GLU B 2 54  ? -3.28   5.852   -4.763  1    65.86  ? 224 GLU B O   1 
ATOM   2870 C  CB  . GLU B 2 54  ? -5.397  8.226   -4.163  1    64.48  ? 224 GLU B CB  1 
ATOM   2871 C  CG  . GLU B 2 54  ? -4.086  8.632   -3.496  1    74.86  ? 224 GLU B CG  1 
ATOM   2872 C  CD  . GLU B 2 54  ? -3.174  9.488   -4.367  1    83.53  ? 224 GLU B CD  1 
ATOM   2873 O  OE1 . GLU B 2 54  ? -3.639  9.933   -5.438  1    80.4   ? 224 GLU B OE1 1 
ATOM   2874 O  OE2 . GLU B 2 54  ? -1.993  9.696   -3.993  1    94.13  ? 224 GLU B OE2 1 
ATOM   2875 N  N   . TYR B 2 55  ? -5.11   5.098   -3.693  1    56.68  ? 225 TYR B N   1 
ATOM   2876 C  CA  . TYR B 2 55  ? -4.37   4.088   -2.953  1    54.73  ? 225 TYR B CA  1 
ATOM   2877 C  C   . TYR B 2 55  ? -4.539  2.732   -3.613  1    52.27  ? 225 TYR B C   1 
ATOM   2878 O  O   . TYR B 2 55  ? -4.047  1.734   -3.089  1    51.71  ? 225 TYR B O   1 
ATOM   2879 C  CB  . TYR B 2 55  ? -4.701  4.093   -1.46   1    54.88  ? 225 TYR B CB  1 
ATOM   2880 C  CG  . TYR B 2 55  ? -4.067  5.265   -0.725  1    61.23  ? 225 TYR B CG  1 
ATOM   2881 C  CD1 . TYR B 2 55  ? -4.682  6.508   -0.721  1    67.73  ? 225 TYR B CD1 1 
ATOM   2882 C  CD2 . TYR B 2 55  ? -2.836  5.146   -0.092  1    63.6   ? 225 TYR B CD2 1 
ATOM   2883 C  CE1 . TYR B 2 55  ? -4.101  7.595   -0.087  1    65.3   ? 225 TYR B CE1 1 
ATOM   2884 C  CE2 . TYR B 2 55  ? -2.26   6.226   0.566   1    72.03  ? 225 TYR B CE2 1 
ATOM   2885 C  CZ  . TYR B 2 55  ? -2.898  7.456   0.572   1    70.02  ? 225 TYR B CZ  1 
ATOM   2886 O  OH  . TYR B 2 55  ? -2.35   8.539   1.201   1    79.52  ? 225 TYR B OH  1 
ATOM   2887 N  N   . LYS B 2 56  ? -5.199  2.737   -4.777  1    50.75  ? 226 LYS B N   1 
ATOM   2888 C  CA  . LYS B 2 56  ? -5.392  1.535   -5.576  1    53.79  ? 226 LYS B CA  1 
ATOM   2889 C  C   . LYS B 2 56  ? -6.073  0.448   -4.732  1    53.13  ? 226 LYS B C   1 
ATOM   2890 O  O   . LYS B 2 56  ? -5.627  -0.694  -4.703  1    53.21  ? 226 LYS B O   1 
ATOM   2891 C  CB  . LYS B 2 56  ? -4.106  1.118   -6.302  1    61.97  ? 226 LYS B CB  1 
ATOM   2892 C  CG  . LYS B 2 56  ? -3.498  2.207   -7.2    1    78.61  ? 226 LYS B CG  1 
ATOM   2893 C  CD  . LYS B 2 56  ? -3.078  1.913   -8.64   1    97.58  ? 226 LYS B CD  1 
ATOM   2894 C  CE  . LYS B 2 56  ? -2.052  0.84    -8.912  1    106.66 ? 226 LYS B CE  1 
ATOM   2895 N  NZ  . LYS B 2 56  ? -0.694  1.161   -8.459  1    104.37 ? 226 LYS B NZ  1 
ATOM   2896 N  N   . LEU B 2 57  ? -7.155  0.822   -4.035  1    47.97  ? 227 LEU B N   1 
ATOM   2897 C  CA  . LEU B 2 57  ? -7.895  -0.103  -3.199  1    44.42  ? 227 LEU B CA  1 
ATOM   2898 C  C   . LEU B 2 57  ? -8.9    -0.85   -4.06   1    46.06  ? 227 LEU B C   1 
ATOM   2899 O  O   . LEU B 2 57  ? -9.243  -0.404  -5.158  1    54.49  ? 227 LEU B O   1 
ATOM   2900 C  CB  . LEU B 2 57  ? -8.632  0.669   -2.11   1    41.38  ? 227 LEU B CB  1 
ATOM   2901 C  CG  . LEU B 2 57  ? -7.761  1.496   -1.169  1    43.55  ? 227 LEU B CG  1 
ATOM   2902 C  CD1 . LEU B 2 57  ? -8.646  2.142   -0.13   1    44.18  ? 227 LEU B CD1 1 
ATOM   2903 C  CD2 . LEU B 2 57  ? -6.707  0.635   -0.505  1    44.09  ? 227 LEU B CD2 1 
ATOM   2904 N  N   . GLN B 2 58  ? -9.388  -1.964  -3.516  1    41.03  ? 228 GLN B N   1 
ATOM   2905 C  CA  . GLN B 2 58  ? -10.451 -2.747  -4.12   1    39.57  ? 228 GLN B CA  1 
ATOM   2906 C  C   . GLN B 2 58  ? -11.769 -1.979  -4.051  1    40.47  ? 228 GLN B C   1 
ATOM   2907 O  O   . GLN B 2 58  ? -12.059 -1.284  -3.063  1    43.82  ? 228 GLN B O   1 
ATOM   2908 C  CB  . GLN B 2 58  ? -10.586 -4.064  -3.35   1    35.8   ? 228 GLN B CB  1 
ATOM   2909 C  CG  . GLN B 2 58  ? -9.353  -4.942  -3.421  1    42.03  ? 228 GLN B CG  1 
ATOM   2910 C  CD  . GLN B 2 58  ? -9.104  -5.368  -4.854  1    46.53  ? 228 GLN B CD  1 
ATOM   2911 O  OE1 . GLN B 2 58  ? -9.954  -6.004  -5.466  1    46.55  ? 228 GLN B OE1 1 
ATOM   2912 N  NE2 . GLN B 2 58  ? -7.984  -4.955  -5.43   1    45.16  ? 228 GLN B NE2 1 
ATOM   2913 N  N   . ASN B 2 59  ? -12.577 -2.156  -5.096  1    40.11  ? 229 ASN B N   1 
ATOM   2914 C  CA  . ASN B 2 59  ? -13.925 -1.614  -5.13   1    42.47  ? 229 ASN B CA  1 
ATOM   2915 C  C   . ASN B 2 59  ? -14.753 -2.15   -3.959  1    43.89  ? 229 ASN B C   1 
ATOM   2916 O  O   . ASN B 2 59  ? -15.656 -1.444  -3.465  1    45.27  ? 229 ASN B O   1 
ATOM   2917 C  CB  . ASN B 2 59  ? -14.62  -1.892  -6.458  1    41.07  ? 229 ASN B CB  1 
ATOM   2918 C  CG  . ASN B 2 59  ? -14.019 -1.163  -7.631  1    43.67  ? 229 ASN B CG  1 
ATOM   2919 O  OD1 . ASN B 2 59  ? -13.262 -0.21   -7.461  1    49.26  ? 229 ASN B OD1 1 
ATOM   2920 N  ND2 . ASN B 2 59  ? -14.344 -1.611  -8.832  1    48.17  ? 229 ASN B ND2 1 
ATOM   2921 N  N   . GLU B 2 60  ? -14.475 -3.414  -3.56   1    40     ? 230 GLU B N   1 
ATOM   2922 C  CA  . GLU B 2 60  ? -15.166 -4.025  -2.433  1    35.66  ? 230 GLU B CA  1 
ATOM   2923 C  C   . GLU B 2 60  ? -14.933 -3.162  -1.192  1    36.87  ? 230 GLU B C   1 
ATOM   2924 O  O   . GLU B 2 60  ? -15.859 -2.906  -0.427  1    41.11  ? 230 GLU B O   1 
ATOM   2925 C  CB  . GLU B 2 60  ? -14.703 -5.467  -2.238  1    35.95  ? 230 GLU B CB  1 
ATOM   2926 C  CG  . GLU B 2 60  ? -15.316 -6.187  -1.036  1    36.71  ? 230 GLU B CG  1 
ATOM   2927 C  CD  . GLU B 2 60  ? -16.81  -6.431  -1.1    1    39.27  ? 230 GLU B CD  1 
ATOM   2928 O  OE1 . GLU B 2 60  ? -17.399 -6.232  -2.17   1    42.6   ? 230 GLU B OE1 1 
ATOM   2929 O  OE2 . GLU B 2 60  ? -17.402 -6.792  -0.073  1    38.02  ? 230 GLU B OE2 1 
ATOM   2930 N  N   . THR B 2 61  ? -13.694 -2.708  -1      1    34.68  ? 231 THR B N   1 
ATOM   2931 C  CA  . THR B 2 61  ? -13.357 -1.878  0.147   1    46.29  ? 231 THR B CA  1 
ATOM   2932 C  C   . THR B 2 61  ? -14.247 -0.626  0.191   1    48.89  ? 231 THR B C   1 
ATOM   2933 O  O   . THR B 2 61  ? -14.721 -0.218  1.258   1    42.13  ? 231 THR B O   1 
ATOM   2934 C  CB  . THR B 2 61  ? -11.87  -1.525  0.127   1    45.61  ? 231 THR B CB  1 
ATOM   2935 O  OG1 . THR B 2 61  ? -11.198 -2.77   -0.004  1    40.52  ? 231 THR B OG1 1 
ATOM   2936 C  CG2 . THR B 2 61  ? -11.437 -0.816  1.398   1    45.78  ? 231 THR B CG2 1 
ATOM   2937 N  N   . LEU B 2 62  ? -14.462 -0.031  -0.988  1    43.06  ? 232 LEU B N   1 
ATOM   2938 C  CA  . LEU B 2 62  ? -15.21  1.205   -1.072  1    41.69  ? 232 LEU B CA  1 
ATOM   2939 C  C   . LEU B 2 62  ? -16.625 0.928   -0.594  1    41.18  ? 232 LEU B C   1 
ATOM   2940 O  O   . LEU B 2 62  ? -17.134 1.679   0.232   1    45.98  ? 232 LEU B O   1 
ATOM   2941 C  CB  . LEU B 2 62  ? -15.179 1.764   -2.496  1    43.39  ? 232 LEU B CB  1 
ATOM   2942 C  CG  . LEU B 2 62  ? -16.178 2.887   -2.806  1    42.26  ? 232 LEU B CG  1 
ATOM   2943 C  CD1 . LEU B 2 62  ? -15.847 4.16    -2.034  1    43.14  ? 232 LEU B CD1 1 
ATOM   2944 C  CD2 . LEU B 2 62  ? -16.243 3.157   -4.3    1    40.07  ? 232 LEU B CD2 1 
ATOM   2945 N  N   . HIS B 2 63  ? -17.237 -0.141  -1.121  1    37.12  ? 233 HIS B N   1 
ATOM   2946 C  CA  . HIS B 2 63  ? -18.597 -0.522  -0.767  1    36.16  ? 233 HIS B CA  1 
ATOM   2947 C  C   . HIS B 2 63  ? -18.753 -0.794  0.744   1    39.28  ? 233 HIS B C   1 
ATOM   2948 O  O   . HIS B 2 63  ? -19.758 -0.404  1.348   1    38.89  ? 233 HIS B O   1 
ATOM   2949 C  CB  . HIS B 2 63  ? -19.053 -1.72   -1.598  1    35.7   ? 233 HIS B CB  1 
ATOM   2950 C  CG  . HIS B 2 63  ? -19.512 -1.427  -2.99   1    42.51  ? 233 HIS B CG  1 
ATOM   2951 N  ND1 . HIS B 2 63  ? -18.633 -1.125  -4.018  1    39.77  ? 233 HIS B ND1 1 
ATOM   2952 C  CD2 . HIS B 2 63  ? -20.756 -1.416  -3.531  1    36.39  ? 233 HIS B CD2 1 
ATOM   2953 C  CE1 . HIS B 2 63  ? -19.341 -0.924  -5.125  1    38.05  ? 233 HIS B CE1 1 
ATOM   2954 N  NE2 . HIS B 2 63  ? -20.613 -1.106  -4.851  1    37.32  ? 233 HIS B NE2 1 
ATOM   2955 N  N   . LEU B 2 64  ? -17.773 -1.481  1.35    1    35.73  ? 234 LEU B N   1 
ATOM   2956 C  CA  . LEU B 2 64  ? -17.86  -1.805  2.756   1    38.43  ? 234 LEU B CA  1 
ATOM   2957 C  C   . LEU B 2 64  ? -17.858 -0.495  3.559   1    45.8   ? 234 LEU B C   1 
ATOM   2958 O  O   . LEU B 2 64  ? -18.631 -0.323  4.505   1    41.91  ? 234 LEU B O   1 
ATOM   2959 C  CB  . LEU B 2 64  ? -16.676 -2.697  3.132   1    37     ? 234 LEU B CB  1 
ATOM   2960 C  CG  . LEU B 2 64  ? -16.732 -4.134  2.604   1    39.77  ? 234 LEU B CG  1 
ATOM   2961 C  CD1 . LEU B 2 64  ? -15.44  -4.841  2.883   1    36.89  ? 234 LEU B CD1 1 
ATOM   2962 C  CD2 . LEU B 2 64  ? -17.899 -4.937  3.209   1    36.58  ? 234 LEU B CD2 1 
ATOM   2963 N  N   . ALA B 2 65  ? -16.999 0.454   3.166   1    42.53  ? 235 ALA B N   1 
ATOM   2964 C  CA  . ALA B 2 65  ? -16.851 1.678   3.931   1    40.05  ? 235 ALA B CA  1 
ATOM   2965 C  C   . ALA B 2 65  ? -18.183 2.444   3.953   1    44.6   ? 235 ALA B C   1 
ATOM   2966 O  O   . ALA B 2 65  ? -18.605 2.997   4.984   1    43.05  ? 235 ALA B O   1 
ATOM   2967 C  CB  . ALA B 2 65  ? -15.729 2.491   3.333   1    33.4   ? 235 ALA B CB  1 
ATOM   2968 N  N   . VAL B 2 66  ? -18.845 2.491   2.791   1    38.03  ? 236 VAL B N   1 
ATOM   2969 C  CA  . VAL B 2 66  ? -20.087 3.22    2.671   1    36.78  ? 236 VAL B CA  1 
ATOM   2970 C  C   . VAL B 2 66  ? -21.127 2.515   3.549   1    41.2   ? 236 VAL B C   1 
ATOM   2971 O  O   . VAL B 2 66  ? -21.903 3.164   4.261   1    51.04  ? 236 VAL B O   1 
ATOM   2972 C  CB  . VAL B 2 66  ? -20.461 3.329   1.177   1    36.72  ? 236 VAL B CB  1 
ATOM   2973 C  CG1 . VAL B 2 66  ? -21.825 3.964   0.96    1    37.84  ? 236 VAL B CG1 1 
ATOM   2974 C  CG2 . VAL B 2 66  ? -19.415 4.105   0.393   1    34.98  ? 236 VAL B CG2 1 
ATOM   2975 N  N   . ASN B 2 67  ? -21.143 1.176   3.528   1    40.55  ? 237 ASN B N   1 
ATOM   2976 C  CA  . ASN B 2 67  ? -22.044 0.411   4.387   1    37.42  ? 237 ASN B CA  1 
ATOM   2977 C  C   . ASN B 2 67  ? -21.813 0.802   5.84    1    35.94  ? 237 ASN B C   1 
ATOM   2978 O  O   . ASN B 2 67  ? -22.792 0.969   6.565   1    37.87  ? 237 ASN B O   1 
ATOM   2979 C  CB  . ASN B 2 67  ? -21.958 -1.104  4.167   1    33.74  ? 237 ASN B CB  1 
ATOM   2980 C  CG  . ASN B 2 67  ? -22.755 -1.874  5.196   1    40.72  ? 237 ASN B CG  1 
ATOM   2981 O  OD1 . ASN B 2 67  ? -22.283 -2.11   6.316   1    45.73  ? 237 ASN B OD1 1 
ATOM   2982 N  ND2 . ASN B 2 67  ? -23.977 -2.258  4.868   1    46.6   ? 237 ASN B ND2 1 
ATOM   2983 N  N   . TYR B 2 68  ? -20.53  0.895   6.257   1    34.61  ? 238 TYR B N   1 
ATOM   2984 C  CA  . TYR B 2 68  ? -20.189 1.219   7.639   1    36.85  ? 238 TYR B CA  1 
ATOM   2985 C  C   . TYR B 2 68  ? -20.717 2.611   7.995   1    40.32  ? 238 TYR B C   1 
ATOM   2986 O  O   . TYR B 2 68  ? -21.218 2.806   9.103   1    43.08  ? 238 TYR B O   1 
ATOM   2987 C  CB  . TYR B 2 68  ? -18.696 1.116   7.957   1    35.04  ? 238 TYR B CB  1 
ATOM   2988 C  CG  . TYR B 2 68  ? -18.077 -0.249  7.672   1    37.77  ? 238 TYR B CG  1 
ATOM   2989 C  CD1 . TYR B 2 68  ? -18.847 -1.399  7.522   1    34.04  ? 238 TYR B CD1 1 
ATOM   2990 C  CD2 . TYR B 2 68  ? -16.71  -0.379  7.548   1    35.97  ? 238 TYR B CD2 1 
ATOM   2991 C  CE1 . TYR B 2 68  ? -18.284 -2.631  7.244   1    33.29  ? 238 TYR B CE1 1 
ATOM   2992 C  CE2 . TYR B 2 68  ? -16.133 -1.602  7.253   1    37.87  ? 238 TYR B CE2 1 
ATOM   2993 C  CZ  . TYR B 2 68  ? -16.92  -2.727  7.101   1    34.77  ? 238 TYR B CZ  1 
ATOM   2994 O  OH  . TYR B 2 68  ? -16.32  -3.908  6.772   1    39.35  ? 238 TYR B OH  1 
ATOM   2995 N  N   . ILE B 2 69  ? -20.555 3.557   7.051   1    37.48  ? 239 ILE B N   1 
ATOM   2996 C  CA  . ILE B 2 69  ? -20.856 4.959   7.257   1    37.36  ? 239 ILE B CA  1 
ATOM   2997 C  C   . ILE B 2 69  ? -22.367 5.098   7.436   1    41.84  ? 239 ILE B C   1 
ATOM   2998 O  O   . ILE B 2 69  ? -22.807 5.748   8.386   1    41.67  ? 239 ILE B O   1 
ATOM   2999 C  CB  . ILE B 2 69  ? -20.344 5.821   6.087   1    36.37  ? 239 ILE B CB  1 
ATOM   3000 C  CG1 . ILE B 2 69  ? -18.835 5.901   6.025   1    35.14  ? 239 ILE B CG1 1 
ATOM   3001 C  CG2 . ILE B 2 69  ? -20.97  7.21    6.101   1    33.38  ? 239 ILE B CG2 1 
ATOM   3002 C  CD1 . ILE B 2 69  ? -18.298 6.426   4.706   1    30.2   ? 239 ILE B CD1 1 
ATOM   3003 N  N   . ASP B 2 70  ? -23.14  4.463   6.54    1    39.28  ? 240 ASP B N   1 
ATOM   3004 C  CA  . ASP B 2 70  ? -24.587 4.59    6.525   1    39.87  ? 240 ASP B CA  1 
ATOM   3005 C  C   . ASP B 2 70  ? -25.173 3.991   7.806   1    40.48  ? 240 ASP B C   1 
ATOM   3006 O  O   . ASP B 2 70  ? -26.026 4.601   8.432   1    46.56  ? 240 ASP B O   1 
ATOM   3007 C  CB  . ASP B 2 70  ? -25.18  4.002   5.251   1    41.01  ? 240 ASP B CB  1 
ATOM   3008 C  CG  . ASP B 2 70  ? -25.031 4.813   3.976   1    41.74  ? 240 ASP B CG  1 
ATOM   3009 O  OD1 . ASP B 2 70  ? -24.967 6.032   4.087   1    39.33  ? 240 ASP B OD1 1 
ATOM   3010 O  OD2 . ASP B 2 70  ? -24.97  4.205   2.868   1    47.42  ? 240 ASP B OD2 1 
ATOM   3011 N  N   . ARG B 2 71  ? -24.697 2.81    8.203   1    39.05  ? 241 ARG B N   1 
ATOM   3012 C  CA  . ARG B 2 71  ? -25.067 2.186   9.461   1    43.82  ? 241 ARG B CA  1 
ATOM   3013 C  C   . ARG B 2 71  ? -24.711 3.085   10.653  1    43.87  ? 241 ARG B C   1 
ATOM   3014 O  O   . ARG B 2 71  ? -25.503 3.225   11.574  1    44.36  ? 241 ARG B O   1 
ATOM   3015 C  CB  . ARG B 2 71  ? -24.385 0.821   9.625   1    41.76  ? 241 ARG B CB  1 
ATOM   3016 C  CG  . ARG B 2 71  ? -25.104 -0.306  8.9     1    38.69  ? 241 ARG B CG  1 
ATOM   3017 C  CD  . ARG B 2 71  ? -24.133 -1.431  8.574   1    39.61  ? 241 ARG B CD  1 
ATOM   3018 N  NE  . ARG B 2 71  ? -23.937 -2.307  9.728   1    38.78  ? 241 ARG B NE  1 
ATOM   3019 C  CZ  . ARG B 2 71  ? -23.009 -3.245  9.795   1    36.63  ? 241 ARG B CZ  1 
ATOM   3020 N  NH1 . ARG B 2 71  ? -22.166 -3.483  8.811   1    34.92  ? 241 ARG B NH1 1 
ATOM   3021 N  NH2 . ARG B 2 71  ? -22.909 -3.948  10.887  1    41.77  ? 241 ARG B NH2 1 
ATOM   3022 N  N   . PHE B 2 72  ? -23.515 3.685   10.64   1    41.53  ? 242 PHE B N   1 
ATOM   3023 C  CA  . PHE B 2 72  ? -23.082 4.527   11.741  1    40.38  ? 242 PHE B CA  1 
ATOM   3024 C  C   . PHE B 2 72  ? -24.04  5.707   11.892  1    43.76  ? 242 PHE B C   1 
ATOM   3025 O  O   . PHE B 2 72  ? -24.499 6.019   13.008  1    44.4   ? 242 PHE B O   1 
ATOM   3026 C  CB  . PHE B 2 72  ? -21.646 5.002   11.518  1    35.47  ? 242 PHE B CB  1 
ATOM   3027 C  CG  . PHE B 2 72  ? -21.058 5.763   12.691  1    36.45  ? 242 PHE B CG  1 
ATOM   3028 C  CD1 . PHE B 2 72  ? -20.511 5.091   13.767  1    38.93  ? 242 PHE B CD1 1 
ATOM   3029 C  CD2 . PHE B 2 72  ? -21.046 7.154   12.716  1    39.11  ? 242 PHE B CD2 1 
ATOM   3030 C  CE1 . PHE B 2 72  ? -19.948 5.8     14.83   1    41.64  ? 242 PHE B CE1 1 
ATOM   3031 C  CE2 . PHE B 2 72  ? -20.499 7.859   13.777  1    38.21  ? 242 PHE B CE2 1 
ATOM   3032 C  CZ  . PHE B 2 72  ? -19.93  7.179   14.834  1    38.6   ? 242 PHE B CZ  1 
ATOM   3033 N  N   . LEU B 2 73  ? -24.328 6.352   10.754  1    41.29  ? 243 LEU B N   1 
ATOM   3034 C  CA  . LEU B 2 73  ? -25.091 7.588   10.746  1    46.52  ? 243 LEU B CA  1 
ATOM   3035 C  C   . LEU B 2 73  ? -26.565 7.3     11.004  1    46.83  ? 243 LEU B C   1 
ATOM   3036 O  O   . LEU B 2 73  ? -27.338 8.232   11.151  1    52.49  ? 243 LEU B O   1 
ATOM   3037 C  CB  . LEU B 2 73  ? -24.906 8.313   9.414   1    45.02  ? 243 LEU B CB  1 
ATOM   3038 C  CG  . LEU B 2 73  ? -23.514 8.885   9.147   1    45.45  ? 243 LEU B CG  1 
ATOM   3039 C  CD1 . LEU B 2 73  ? -23.45  9.501   7.775   1    38.78  ? 243 LEU B CD1 1 
ATOM   3040 C  CD2 . LEU B 2 73  ? -23.036 9.837   10.274  1    43.32  ? 243 LEU B CD2 1 
ATOM   3041 N  N   . SER B 2 74  ? -26.94  6.019   11.015  1    45.43  ? 244 SER B N   1 
ATOM   3042 C  CA  . SER B 2 74  ? -28.286 5.596   11.361  1    46.58  ? 244 SER B CA  1 
ATOM   3043 C  C   . SER B 2 74  ? -28.542 5.719   12.872  1    47.86  ? 244 SER B C   1 
ATOM   3044 O  O   . SER B 2 74  ? -29.669 5.96    13.272  1    44.99  ? 244 SER B O   1 
ATOM   3045 C  CB  . SER B 2 74  ? -28.546 4.207   10.842  1    44.6   ? 244 SER B CB  1 
ATOM   3046 O  OG  . SER B 2 74  ? -28.701 4.237   9.426   1    45.01  ? 244 SER B OG  1 
ATOM   3047 N  N   . SER B 2 75  ? -27.5   5.595   13.722  1    45.38  ? 245 SER B N   1 
ATOM   3048 C  CA  . SER B 2 75  ? -27.73  5.72    15.161  1    45.42  ? 245 SER B CA  1 
ATOM   3049 C  C   . SER B 2 75  ? -26.922 6.841   15.812  1    46.93  ? 245 SER B C   1 
ATOM   3050 O  O   . SER B 2 75  ? -27.202 7.198   16.946  1    52.85  ? 245 SER B O   1 
ATOM   3051 C  CB  . SER B 2 75  ? -27.551 4.441   15.91   1    40.32  ? 245 SER B CB  1 
ATOM   3052 O  OG  . SER B 2 75  ? -26.181 4.155   16.037  1    44.22  ? 245 SER B OG  1 
ATOM   3053 N  N   . MET B 2 76  ? -25.928 7.398   15.11   1    47.04  ? 246 MET B N   1 
ATOM   3054 C  CA  . MET B 2 76  ? -25.084 8.436   15.694  1    41.82  ? 246 MET B CA  1 
ATOM   3055 C  C   . MET B 2 76  ? -25.202 9.72    14.865  1    47.02  ? 246 MET B C   1 
ATOM   3056 O  O   . MET B 2 76  ? -24.998 9.743   13.64   1    48.11  ? 246 MET B O   1 
ATOM   3057 C  CB  . MET B 2 76  ? -23.62  8.011   15.726  1    36.57  ? 246 MET B CB  1 
ATOM   3058 C  CG  . MET B 2 76  ? -23.389 6.71    16.396  1    39.34  ? 246 MET B CG  1 
ATOM   3059 S  SD  . MET B 2 76  ? -23.55  6.818   18.179  1    46.1   ? 246 MET B SD  1 
ATOM   3060 C  CE  . MET B 2 76  ? -22.142 7.836   18.629  1    41.83  ? 246 MET B CE  1 
ATOM   3061 N  N   . SER B 2 77  ? -25.564 10.784  15.572  1    46.29  ? 247 SER B N   1 
ATOM   3062 C  CA  . SER B 2 77  ? -25.714 12.106  15.012  1    46.36  ? 247 SER B CA  1 
ATOM   3063 C  C   . SER B 2 77  ? -24.325 12.749  14.964  1    46.73  ? 247 SER B C   1 
ATOM   3064 O  O   . SER B 2 77  ? -23.546 12.563  15.895  1    49.1   ? 247 SER B O   1 
ATOM   3065 C  CB  . SER B 2 77  ? -26.705 12.829  15.885  1    48.67  ? 247 SER B CB  1 
ATOM   3066 O  OG  . SER B 2 77  ? -26.771 14.193  15.534  1    62.55  ? 247 SER B OG  1 
ATOM   3067 N  N   . VAL B 2 78  ? -23.976 13.398  13.837  1    46.92  ? 248 VAL B N   1 
ATOM   3068 C  CA  . VAL B 2 78  ? -22.62  13.862  13.564  1    44.84  ? 248 VAL B CA  1 
ATOM   3069 C  C   . VAL B 2 78  ? -22.631 15.281  13.008  1    49.94  ? 248 VAL B C   1 
ATOM   3070 O  O   . VAL B 2 78  ? -23.405 15.559  12.098  1    55.7   ? 248 VAL B O   1 
ATOM   3071 C  CB  . VAL B 2 78  ? -21.941 12.903  12.576  1    45.34  ? 248 VAL B CB  1 
ATOM   3072 C  CG1 . VAL B 2 78  ? -20.541 13.367  12.188  1    44.1   ? 248 VAL B CG1 1 
ATOM   3073 C  CG2 . VAL B 2 78  ? -21.839 11.493  13.167  1    50.42  ? 248 VAL B CG2 1 
ATOM   3074 N  N   . LEU B 2 79  ? -21.772 16.172  13.549  1    51.04  ? 249 LEU B N   1 
ATOM   3075 C  CA  . LEU B 2 79  ? -21.583 17.521  13.022  1    51.59  ? 249 LEU B CA  1 
ATOM   3076 C  C   . LEU B 2 79  ? -20.798 17.483  11.702  1    52.71  ? 249 LEU B C   1 
ATOM   3077 O  O   . LEU B 2 79  ? -19.888 16.665  11.523  1    47.1   ? 249 LEU B O   1 
ATOM   3078 C  CB  . LEU B 2 79  ? -20.896 18.41   14.057  1    52.78  ? 249 LEU B CB  1 
ATOM   3079 C  CG  . LEU B 2 79  ? -21.687 18.74   15.325  1    59.16  ? 249 LEU B CG  1 
ATOM   3080 C  CD1 . LEU B 2 79  ? -20.89  19.654  16.233  1    56.62  ? 249 LEU B CD1 1 
ATOM   3081 C  CD2 . LEU B 2 79  ? -23.054 19.342  15.019  1    60.51  ? 249 LEU B CD2 1 
ATOM   3082 N  N   . ARG B 2 80  ? -21.124 18.406  10.786  1    54.5   ? 250 ARG B N   1 
ATOM   3083 C  CA  . ARG B 2 80  ? -20.565 18.418  9.435   1    49.57  ? 250 ARG B CA  1 
ATOM   3084 C  C   . ARG B 2 80  ? -19.038 18.417  9.502   1    52.64  ? 250 ARG B C   1 
ATOM   3085 O  O   . ARG B 2 80  ? -18.402 17.727  8.696   1    47.6   ? 250 ARG B O   1 
ATOM   3086 C  CB  . ARG B 2 80  ? -21.084 19.593  8.599   1    51.57  ? 250 ARG B CB  1 
ATOM   3087 C  CG  . ARG B 2 80  ? -20.538 20.937  9.075   1    55.86  ? 250 ARG B CG  1 
ATOM   3088 C  CD  . ARG B 2 80  ? -21.195 22.091  8.372   1    55.37  ? 250 ARG B CD  1 
ATOM   3089 N  NE  . ARG B 2 80  ? -22.633 22.113  8.667   1    63.9   ? 250 ARG B NE  1 
ATOM   3090 C  CZ  . ARG B 2 80  ? -23.524 22.969  8.131   1    66.16  ? 250 ARG B CZ  1 
ATOM   3091 N  NH1 . ARG B 2 80  ? -23.181 23.887  7.24    1    63.31  ? 250 ARG B NH1 1 
ATOM   3092 N  NH2 . ARG B 2 80  ? -24.781 22.912  8.498   1    65.82  ? 250 ARG B NH2 1 
ATOM   3093 N  N   . GLY B 2 81  ? -18.471 19.124  10.507  1    52.76  ? 251 GLY B N   1 
ATOM   3094 C  CA  . GLY B 2 81  ? -17.042 19.136  10.805  1    47.99  ? 251 GLY B CA  1 
ATOM   3095 C  C   . GLY B 2 81  ? -16.432 17.749  11.054  1    48.99  ? 251 GLY B C   1 
ATOM   3096 O  O   . GLY B 2 81  ? -15.221 17.575  10.915  1    48     ? 251 GLY B O   1 
ATOM   3097 N  N   . LYS B 2 82  ? -17.256 16.758  11.429  1    46.63  ? 252 LYS B N   1 
ATOM   3098 C  CA  . LYS B 2 82  ? -16.752 15.454  11.831  1    43.95  ? 252 LYS B CA  1 
ATOM   3099 C  C   . LYS B 2 82  ? -17.121 14.355  10.831  1    42.96  ? 252 LYS B C   1 
ATOM   3100 O  O   . LYS B 2 82  ? -16.721 13.198  10.994  1    42.18  ? 252 LYS B O   1 
ATOM   3101 C  CB  . LYS B 2 82  ? -17.284 15.103  13.224  1    42.36  ? 252 LYS B CB  1 
ATOM   3102 C  CG  . LYS B 2 82  ? -16.762 15.994  14.351  1    46.12  ? 252 LYS B CG  1 
ATOM   3103 C  CD  . LYS B 2 82  ? -15.237 15.924  14.402  1    49.48  ? 252 LYS B CD  1 
ATOM   3104 C  CE  . LYS B 2 82  ? -14.649 16.232  15.736  1    52.23  ? 252 LYS B CE  1 
ATOM   3105 N  NZ  . LYS B 2 82  ? -14.709 17.687  15.863  1    55.13  ? 252 LYS B NZ  1 
ATOM   3106 N  N   . LEU B 2 83  ? -17.905 14.695  9.803   1    42.61  ? 253 LEU B N   1 
ATOM   3107 C  CA  . LEU B 2 83  ? -18.364 13.668  8.882   1    44.23  ? 253 LEU B CA  1 
ATOM   3108 C  C   . LEU B 2 83  ? -17.157 12.968  8.267   1    45.62  ? 253 LEU B C   1 
ATOM   3109 O  O   . LEU B 2 83  ? -17.148 11.742  8.122   1    51.6   ? 253 LEU B O   1 
ATOM   3110 C  CB  . LEU B 2 83  ? -19.23  14.316  7.801   1    41.85  ? 253 LEU B CB  1 
ATOM   3111 C  CG  . LEU B 2 83  ? -19.832 13.394  6.738   1    40.72  ? 253 LEU B CG  1 
ATOM   3112 C  CD1 . LEU B 2 83  ? -20.694 12.279  7.375   1    38.43  ? 253 LEU B CD1 1 
ATOM   3113 C  CD2 . LEU B 2 83  ? -20.676 14.303  5.84    1    40.24  ? 253 LEU B CD2 1 
ATOM   3114 N  N   . GLN B 2 84  ? -16.135 13.759  7.906   1    45.89  ? 254 GLN B N   1 
ATOM   3115 C  CA  . GLN B 2 84  ? -14.966 13.207  7.227   1    48.54  ? 254 GLN B CA  1 
ATOM   3116 C  C   . GLN B 2 84  ? -14.163 12.273  8.139   1    43.78  ? 254 GLN B C   1 
ATOM   3117 O  O   . GLN B 2 84  ? -13.496 11.365  7.676   1    43.85  ? 254 GLN B O   1 
ATOM   3118 C  CB  . GLN B 2 84  ? -14.097 14.306  6.636   1    47.71  ? 254 GLN B CB  1 
ATOM   3119 C  CG  . GLN B 2 84  ? -12.96  13.752  5.8     1    48.54  ? 254 GLN B CG  1 
ATOM   3120 C  CD  . GLN B 2 84  ? -12.171 14.831  5.102   1    51.48  ? 254 GLN B CD  1 
ATOM   3121 O  OE1 . GLN B 2 84  ? -11.675 14.626  3.994   1    52.16  ? 254 GLN B OE1 1 
ATOM   3122 N  NE2 . GLN B 2 84  ? -11.995 15.964  5.763   1    51.53  ? 254 GLN B NE2 1 
ATOM   3123 N  N   . LEU B 2 85  ? -14.225 12.514  9.439   1    45.15  ? 255 LEU B N   1 
ATOM   3124 C  CA  . LEU B 2 85  ? -13.566 11.668  10.413  1    44.9   ? 255 LEU B CA  1 
ATOM   3125 C  C   . LEU B 2 85  ? -14.242 10.304  10.463  1    45.43  ? 255 LEU B C   1 
ATOM   3126 O  O   . LEU B 2 85  ? -13.523 9.319   10.622  1    47.6   ? 255 LEU B O   1 
ATOM   3127 C  CB  . LEU B 2 85  ? -13.572 12.336  11.783  1    42.35  ? 255 LEU B CB  1 
ATOM   3128 C  CG  . LEU B 2 85  ? -12.854 11.55   12.883  1    41.91  ? 255 LEU B CG  1 
ATOM   3129 C  CD1 . LEU B 2 85  ? -11.424 11.158  12.494  1    39.94  ? 255 LEU B CD1 1 
ATOM   3130 C  CD2 . LEU B 2 85  ? -12.84  12.401  14.161  1    42.62  ? 255 LEU B CD2 1 
ATOM   3131 N  N   . VAL B 2 86  ? -15.593 10.275  10.375  1    41.38  ? 256 VAL B N   1 
ATOM   3132 C  CA  . VAL B 2 86  ? -16.361 9.042   10.329  1    38.3   ? 256 VAL B CA  1 
ATOM   3133 C  C   . VAL B 2 86  ? -15.964 8.285   9.068   1    38.78  ? 256 VAL B C   1 
ATOM   3134 O  O   . VAL B 2 86  ? -15.528 7.15    9.145   1    35.9   ? 256 VAL B O   1 
ATOM   3135 C  CB  . VAL B 2 86  ? -17.886 9.273   10.34   1    44.8   ? 256 VAL B CB  1 
ATOM   3136 C  CG1 . VAL B 2 86  ? -18.66  7.975   10.136  1    40.82  ? 256 VAL B CG1 1 
ATOM   3137 C  CG2 . VAL B 2 86  ? -18.363 10.005  11.592  1    40.06  ? 256 VAL B CG2 1 
ATOM   3138 N  N   . GLY B 2 87  ? -16.038 8.961   7.912   1    40.86  ? 257 GLY B N   1 
ATOM   3139 C  CA  . GLY B 2 87  ? -15.638 8.391   6.631   1    41.17  ? 257 GLY B CA  1 
ATOM   3140 C  C   . GLY B 2 87  ? -14.215 7.825   6.627   1    44.42  ? 257 GLY B C   1 
ATOM   3141 O  O   . GLY B 2 87  ? -13.983 6.747   6.085   1    43.48  ? 257 GLY B O   1 
ATOM   3142 N  N   . THR B 2 88  ? -13.263 8.549   7.231   1    45     ? 258 THR B N   1 
ATOM   3143 C  CA  . THR B 2 88  ? -11.858 8.153   7.255   1    45.45  ? 258 THR B CA  1 
ATOM   3144 C  C   . THR B 2 88  ? -11.684 6.86    8.049   1    45.58  ? 258 THR B C   1 
ATOM   3145 O  O   . THR B 2 88  ? -11.025 5.947   7.58    1    47.94  ? 258 THR B O   1 
ATOM   3146 C  CB  . THR B 2 88  ? -10.996 9.292   7.8     1    45.57  ? 258 THR B CB  1 
ATOM   3147 O  OG1 . THR B 2 88  ? -11.19  10.38   6.893   1    49.25  ? 258 THR B OG1 1 
ATOM   3148 C  CG2 . THR B 2 88  ? -9.522  8.946   7.868   1    44.23  ? 258 THR B CG2 1 
ATOM   3149 N  N   . ALA B 2 89  ? -12.299 6.775   9.233   1    46.22  ? 259 ALA B N   1 
ATOM   3150 C  CA  . ALA B 2 89  ? -12.229 5.57    10.062  1    44.57  ? 259 ALA B CA  1 
ATOM   3151 C  C   . ALA B 2 89  ? -12.956 4.405   9.378   1    40.91  ? 259 ALA B C   1 
ATOM   3152 O  O   . ALA B 2 89  ? -12.586 3.239   9.488   1    39.97  ? 259 ALA B O   1 
ATOM   3153 C  CB  . ALA B 2 89  ? -12.832 5.851   11.425  1    40.73  ? 259 ALA B CB  1 
ATOM   3154 N  N   . ALA B 2 90  ? -14.034 4.729   8.676   1    38.28  ? 260 ALA B N   1 
ATOM   3155 C  CA  . ALA B 2 90  ? -14.77  3.721   7.946   1    38.12  ? 260 ALA B CA  1 
ATOM   3156 C  C   . ALA B 2 90  ? -13.853 3.107   6.881   1    43.88  ? 260 ALA B C   1 
ATOM   3157 O  O   . ALA B 2 90  ? -13.791 1.871   6.771   1    41.62  ? 260 ALA B O   1 
ATOM   3158 C  CB  . ALA B 2 90  ? -16.029 4.336   7.365   1    32.86  ? 260 ALA B CB  1 
ATOM   3159 N  N   . MET B 2 91  ? -13.13  3.965   6.123   1    42.28  ? 261 MET B N   1 
ATOM   3160 C  CA  . MET B 2 91  ? -12.269 3.507   5.033   1    41.89  ? 261 MET B CA  1 
ATOM   3161 C  C   . MET B 2 91  ? -11.116 2.656   5.591   1    41.88  ? 261 MET B C   1 
ATOM   3162 O  O   . MET B 2 91  ? -10.769 1.619   5.015   1    40.17  ? 261 MET B O   1 
ATOM   3163 C  CB  . MET B 2 91  ? -11.733 4.69    4.216   1    43.06  ? 261 MET B CB  1 
ATOM   3164 C  CG  . MET B 2 91  ? -11.234 4.351   2.827   1    46.16  ? 261 MET B CG  1 
ATOM   3165 S  SD  . MET B 2 91  ? -12.462 3.474   1.831   1    50.25  ? 261 MET B SD  1 
ATOM   3166 C  CE  . MET B 2 91  ? -12.039 3.924   0.15    1    53.66  ? 261 MET B CE  1 
ATOM   3167 N  N   . LEU B 2 92  ? -10.575 3.091   6.739   1    37.03  ? 262 LEU B N   1 
ATOM   3168 C  CA  . LEU B 2 92  ? -9.548  2.36    7.453   1    42.05  ? 262 LEU B CA  1 
ATOM   3169 C  C   . LEU B 2 92  ? -10.034 0.958   7.837   1    42.13  ? 262 LEU B C   1 
ATOM   3170 O  O   . LEU B 2 92  ? -9.322  -0.037  7.629   1    45.46  ? 262 LEU B O   1 
ATOM   3171 C  CB  . LEU B 2 92  ? -9.116  3.176   8.673   1    41.08  ? 262 LEU B CB  1 
ATOM   3172 C  CG  . LEU B 2 92  ? -8.073  2.543   9.604   1    38.41  ? 262 LEU B CG  1 
ATOM   3173 C  CD1 . LEU B 2 92  ? -6.751  2.319   8.916   1    38.28  ? 262 LEU B CD1 1 
ATOM   3174 C  CD2 . LEU B 2 92  ? -7.863  3.426   10.817  1    39.59  ? 262 LEU B CD2 1 
ATOM   3175 N  N   . LEU B 2 93  ? -11.227 0.88    8.421   1    36.06  ? 263 LEU B N   1 
ATOM   3176 C  CA  . LEU B 2 93  ? -11.699 -0.4    8.92    1    37.22  ? 263 LEU B CA  1 
ATOM   3177 C  C   . LEU B 2 93  ? -11.974 -1.316  7.729   1    38.66  ? 263 LEU B C   1 
ATOM   3178 O  O   . LEU B 2 93  ? -11.643 -2.495  7.756   1    39.63  ? 263 LEU B O   1 
ATOM   3179 C  CB  . LEU B 2 93  ? -12.948 -0.189  9.776   1    36.59  ? 263 LEU B CB  1 
ATOM   3180 C  CG  . LEU B 2 93  ? -12.711 0.262   11.227  1    38.64  ? 263 LEU B CG  1 
ATOM   3181 C  CD1 . LEU B 2 93  ? -14.048 0.671   11.877  1    35.15  ? 263 LEU B CD1 1 
ATOM   3182 C  CD2 . LEU B 2 93  ? -12.104 -0.888  12.032  1    34.11  ? 263 LEU B CD2 1 
ATOM   3183 N  N   . ALA B 2 94  ? -12.564 -0.759  6.668   1    39.87  ? 264 ALA B N   1 
ATOM   3184 C  CA  . ALA B 2 94  ? -12.818 -1.502  5.432   1    38.63  ? 264 ALA B CA  1 
ATOM   3185 C  C   . ALA B 2 94  ? -11.529 -2.049  4.818   1    36.1   ? 264 ALA B C   1 
ATOM   3186 O  O   . ALA B 2 94  ? -11.474 -3.201  4.414   1    36.44  ? 264 ALA B O   1 
ATOM   3187 C  CB  . ALA B 2 94  ? -13.539 -0.623  4.446   1    35.28  ? 264 ALA B CB  1 
ATOM   3188 N  N   . SER B 2 95  ? -10.493 -1.211  4.768   1    37.84  ? 265 SER B N   1 
ATOM   3189 C  CA  . SER B 2 95  ? -9.176  -1.568  4.26    1    36.1   ? 265 SER B CA  1 
ATOM   3190 C  C   . SER B 2 95  ? -8.554  -2.678  5.096   1    36.87  ? 265 SER B C   1 
ATOM   3191 O  O   . SER B 2 95  ? -8.076  -3.653  4.529   1    42.88  ? 265 SER B O   1 
ATOM   3192 C  CB  . SER B 2 95  ? -8.26   -0.365  4.222   1    37.26  ? 265 SER B CB  1 
ATOM   3193 O  OG  . SER B 2 95  ? -8.772  0.637   3.349   1    43.26  ? 265 SER B OG  1 
ATOM   3194 N  N   . LYS B 2 96  ? -8.544  -2.545  6.429   1    35.47  ? 266 LYS B N   1 
ATOM   3195 C  CA  . LYS B 2 96  ? -8.02   -3.621  7.269   1    37.74  ? 266 LYS B CA  1 
ATOM   3196 C  C   . LYS B 2 96  ? -8.795  -4.929  7.082   1    37.1   ? 266 LYS B C   1 
ATOM   3197 O  O   . LYS B 2 96  ? -8.211  -5.99   7.187   1    42.3   ? 266 LYS B O   1 
ATOM   3198 C  CB  . LYS B 2 96  ? -8.016  -3.269  8.755   1    37.81  ? 266 LYS B CB  1 
ATOM   3199 C  CG  . LYS B 2 96  ? -6.994  -2.229  9.191   1    37.64  ? 266 LYS B CG  1 
ATOM   3200 C  CD  . LYS B 2 96  ? -7.25   -1.799  10.628  1    36.97  ? 266 LYS B CD  1 
ATOM   3201 C  CE  . LYS B 2 96  ? -6.185  -0.904  11.195  1    41.96  ? 266 LYS B CE  1 
ATOM   3202 N  NZ  . LYS B 2 96  ? -6.462  -0.62   12.619  1    40.76  ? 266 LYS B NZ  1 
ATOM   3203 N  N   . PHE B 2 97  ? -10.082 -4.871  6.747   1    33.49  ? 267 PHE B N   1 
ATOM   3204 C  CA  . PHE B 2 97  ? -10.852 -6.083  6.55    1    36.59  ? 267 PHE B CA  1 
ATOM   3205 C  C   . PHE B 2 97  ? -10.563 -6.72   5.195   1    37.44  ? 267 PHE B C   1 
ATOM   3206 O  O   . PHE B 2 97  ? -10.418 -7.938  5.095   1    39.63  ? 267 PHE B O   1 
ATOM   3207 C  CB  . PHE B 2 97  ? -12.348 -5.748  6.6     1    39.94  ? 267 PHE B CB  1 
ATOM   3208 C  CG  . PHE B 2 97  ? -13.272 -6.954  6.54    1    39.53  ? 267 PHE B CG  1 
ATOM   3209 C  CD1 . PHE B 2 97  ? -13.558 -7.689  7.687   1    38.4   ? 267 PHE B CD1 1 
ATOM   3210 C  CD2 . PHE B 2 97  ? -13.856 -7.339  5.333   1    40.92  ? 267 PHE B CD2 1 
ATOM   3211 C  CE1 . PHE B 2 97  ? -14.396 -8.796  7.623   1    37     ? 267 PHE B CE1 1 
ATOM   3212 C  CE2 . PHE B 2 97  ? -14.696 -8.451  5.273   1    38.15  ? 267 PHE B CE2 1 
ATOM   3213 C  CZ  . PHE B 2 97  ? -14.949 -9.185  6.422   1    38.34  ? 267 PHE B CZ  1 
ATOM   3214 N  N   . GLU B 2 98  ? -10.557 -5.901  4.145   1    36.19  ? 268 GLU B N   1 
ATOM   3215 C  CA  . GLU B 2 98  ? -10.681 -6.425  2.792   1    36.2   ? 268 GLU B CA  1 
ATOM   3216 C  C   . GLU B 2 98  ? -9.352  -6.419  2.026   1    37.64  ? 268 GLU B C   1 
ATOM   3217 O  O   . GLU B 2 98  ? -9.186  -7.269  1.152   1    38.97  ? 268 GLU B O   1 
ATOM   3218 C  CB  . GLU B 2 98  ? -11.704 -5.621  2.007   1    35.94  ? 268 GLU B CB  1 
ATOM   3219 C  CG  . GLU B 2 98  ? -12.182 -6.326  0.734   1    41.5   ? 268 GLU B CG  1 
ATOM   3220 C  CD  . GLU B 2 98  ? -12.846 -7.688  0.948   1    43.36  ? 268 GLU B CD  1 
ATOM   3221 O  OE1 . GLU B 2 98  ? -13.479 -7.914  2.013   1    41.56  ? 268 GLU B OE1 1 
ATOM   3222 O  OE2 . GLU B 2 98  ? -12.771 -8.517  0.017   1    40.57  ? 268 GLU B OE2 1 
ATOM   3223 N  N   . GLU B 2 99  ? -8.408  -5.524  2.389   1    36.15  ? 269 GLU B N   1 
ATOM   3224 C  CA  . GLU B 2 99  ? -7.139  -5.367  1.695   1    39.2   ? 269 GLU B CA  1 
ATOM   3225 C  C   . GLU B 2 99  ? -6.064  -6.351  2.175   1    45.11  ? 269 GLU B C   1 
ATOM   3226 O  O   . GLU B 2 99  ? -5.901  -6.608  3.369   1    46.08  ? 269 GLU B O   1 
ATOM   3227 C  CB  . GLU B 2 99  ? -6.636  -3.931  1.781   1    36.85  ? 269 GLU B CB  1 
ATOM   3228 C  CG  . GLU B 2 99  ? -7.573  -2.96   1.068   1    40.49  ? 269 GLU B CG  1 
ATOM   3229 C  CD  . GLU B 2 99  ? -7.611  -3.053  -0.451  1    42.72  ? 269 GLU B CD  1 
ATOM   3230 O  OE1 . GLU B 2 99  ? -6.574  -3.494  -1.05   1    47.06  ? 269 GLU B OE1 1 
ATOM   3231 O  OE2 . GLU B 2 99  ? -8.678  -2.705  -1.02   1    35.78  ? 269 GLU B OE2 1 
ATOM   3232 N  N   . ILE B 2 100 ? -5.293  -6.865  1.208   1    43.02  ? 270 ILE B N   1 
ATOM   3233 C  CA  . ILE B 2 100 ? -4.067  -7.587  1.477   1    42.55  ? 270 ILE B CA  1 
ATOM   3234 C  C   . ILE B 2 100 ? -3.077  -6.619  2.115   1    45.7   ? 270 ILE B C   1 
ATOM   3235 O  O   . ILE B 2 100 ? -2.375  -6.992  3.039   1    49.59  ? 270 ILE B O   1 
ATOM   3236 C  CB  . ILE B 2 100 ? -3.49   -8.146  0.156   1    45.33  ? 270 ILE B CB  1 
ATOM   3237 C  CG1 . ILE B 2 100 ? -4.427  -9.143  -0.523  1    43.01  ? 270 ILE B CG1 1 
ATOM   3238 C  CG2 . ILE B 2 100 ? -2.079  -8.715  0.341   1    39.91  ? 270 ILE B CG2 1 
ATOM   3239 C  CD1 . ILE B 2 100 ? -3.977  -9.53   -1.921  1    43.72  ? 270 ILE B CD1 1 
ATOM   3240 N  N   . TYR B 2 101 ? -2.997  -5.399  1.57    1    45.34  ? 271 TYR B N   1 
ATOM   3241 C  CA  . TYR B 2 101 ? -2.025  -4.396  1.981   1    51.8   ? 271 TYR B CA  1 
ATOM   3242 C  C   . TYR B 2 101 ? -2.742  -3.086  2.31    1    50.33  ? 271 TYR B C   1 
ATOM   3243 O  O   . TYR B 2 101 ? -2.779  -2.159  1.503   1    53.89  ? 271 TYR B O   1 
ATOM   3244 C  CB  . TYR B 2 101 ? -0.955  -4.192  0.891   1    48.87  ? 271 TYR B CB  1 
ATOM   3245 C  CG  . TYR B 2 101 ? -0.006  -5.36   0.737   1    51.92  ? 271 TYR B CG  1 
ATOM   3246 C  CD1 . TYR B 2 101 ? 0.757   -5.798  1.825   1    57.95  ? 271 TYR B CD1 1 
ATOM   3247 C  CD2 . TYR B 2 101 ? 0.129   -6.028  -0.482  1    55.67  ? 271 TYR B CD2 1 
ATOM   3248 C  CE1 . TYR B 2 101 ? 1.643   -6.862  1.705   1    60.61  ? 271 TYR B CE1 1 
ATOM   3249 C  CE2 . TYR B 2 101 ? 1.005   -7.102  -0.613  1    57.36  ? 271 TYR B CE2 1 
ATOM   3250 C  CZ  . TYR B 2 101 ? 1.744   -7.524  0.486   1    62.12  ? 271 TYR B CZ  1 
ATOM   3251 O  OH  . TYR B 2 101 ? 2.61    -8.575  0.404   1    79.85  ? 271 TYR B OH  1 
ATOM   3252 N  N   . PRO B 2 102 ? -3.347  -2.945  3.504   1    51.4   ? 272 PRO B N   1 
ATOM   3253 C  CA  . PRO B 2 102 ? -4.102  -1.723  3.812   1    47.87  ? 272 PRO B CA  1 
ATOM   3254 C  C   . PRO B 2 102 ? -3.124  -0.562  3.922   1    44.62  ? 272 PRO B C   1 
ATOM   3255 O  O   . PRO B 2 102 ? -1.985  -0.75   4.357   1    49.19  ? 272 PRO B O   1 
ATOM   3256 C  CB  . PRO B 2 102 ? -4.803  -2.033  5.148   1    44.63  ? 272 PRO B CB  1 
ATOM   3257 C  CG  . PRO B 2 102 ? -3.939  -3.12   5.768   1    45.28  ? 272 PRO B CG  1 
ATOM   3258 C  CD  . PRO B 2 102 ? -3.317  -3.914  4.61    1    46.38  ? 272 PRO B CD  1 
ATOM   3259 N  N   . PRO B 2 103 ? -3.508  0.667   3.512   1    42.99  ? 273 PRO B N   1 
ATOM   3260 C  CA  . PRO B 2 103 ? -2.673  1.845   3.786   1    46.44  ? 273 PRO B CA  1 
ATOM   3261 C  C   . PRO B 2 103 ? -2.506  2.007   5.302   1    49.31  ? 273 PRO B C   1 
ATOM   3262 O  O   . PRO B 2 103 ? -3.416  1.743   6.082   1    47.4   ? 273 PRO B O   1 
ATOM   3263 C  CB  . PRO B 2 103 ? -3.468  2.998   3.165   1    44.13  ? 273 PRO B CB  1 
ATOM   3264 C  CG  . PRO B 2 103 ? -4.395  2.349   2.169   1    42.24  ? 273 PRO B CG  1 
ATOM   3265 C  CD  . PRO B 2 103 ? -4.714  0.985   2.741   1    40.87  ? 273 PRO B CD  1 
ATOM   3266 N  N   . GLU B 2 104 ? -1.328  2.438   5.738   1    52.32  ? 274 GLU B N   1 
ATOM   3267 C  CA  . GLU B 2 104 ? -1.117  2.72    7.151   1    55.81  ? 274 GLU B CA  1 
ATOM   3268 C  C   . GLU B 2 104 ? -2.024  3.868   7.614   1    56.09  ? 274 GLU B C   1 
ATOM   3269 O  O   . GLU B 2 104 ? -2.455  4.721   6.833   1    54.63  ? 274 GLU B O   1 
ATOM   3270 C  CB  . GLU B 2 104 ? 0.331   3.152   7.368   1    62.59  ? 274 GLU B CB  1 
ATOM   3271 C  CG  . GLU B 2 104 ? 1.383   2.08    7.098   1    71.72  ? 274 GLU B CG  1 
ATOM   3272 C  CD  . GLU B 2 104 ? 2.734   2.671   6.694   1    90.09  ? 274 GLU B CD  1 
ATOM   3273 O  OE1 . GLU B 2 104 ? 3.574   1.86    6.222   1    96.37  ? 274 GLU B OE1 1 
ATOM   3274 O  OE2 . GLU B 2 104 ? 2.957   3.916   6.821   1    95.85  ? 274 GLU B OE2 1 
ATOM   3275 N  N   . VAL B 2 105 ? -2.325  3.877   8.913   1    57.39  ? 275 VAL B N   1 
ATOM   3276 C  CA  . VAL B 2 105 ? -3.082  4.939   9.566   1    59.99  ? 275 VAL B CA  1 
ATOM   3277 C  C   . VAL B 2 105 ? -2.586  6.311   9.11    1    60.25  ? 275 VAL B C   1 
ATOM   3278 O  O   . VAL B 2 105 ? -3.399  7.155   8.762   1    65.19  ? 275 VAL B O   1 
ATOM   3279 C  CB  . VAL B 2 105 ? -3.004  4.784   11.098  1    56.4   ? 275 VAL B CB  1 
ATOM   3280 C  CG1 . VAL B 2 105 ? -3.576  5.974   11.837  1    52.96  ? 275 VAL B CG1 1 
ATOM   3281 C  CG2 . VAL B 2 105 ? -3.726  3.518   11.52   1    62.16  ? 275 VAL B CG2 1 
ATOM   3282 N  N   . ALA B 2 106 ? -1.262  6.516   9.099   1    55.63  ? 276 ALA B N   1 
ATOM   3283 C  CA  . ALA B 2 106 ? -0.699  7.82    8.823   1    56.9   ? 276 ALA B CA  1 
ATOM   3284 C  C   . ALA B 2 106 ? -1.09   8.3     7.42    1    58.91  ? 276 ALA B C   1 
ATOM   3285 O  O   . ALA B 2 106 ? -1.208  9.504   7.204   1    67.56  ? 276 ALA B O   1 
ATOM   3286 C  CB  . ALA B 2 106 ? 0.787   7.807   9.055   1    53.6   ? 276 ALA B CB  1 
ATOM   3287 N  N   . GLU B 2 107 ? -1.281  7.37    6.474   1    52.89  ? 277 GLU B N   1 
ATOM   3288 C  CA  . GLU B 2 107 ? -1.688  7.746   5.136   1    57.57  ? 277 GLU B CA  1 
ATOM   3289 C  C   . GLU B 2 107 ? -3.135  8.244   5.177   1    57.43  ? 277 GLU B C   1 
ATOM   3290 O  O   . GLU B 2 107 ? -3.498  9.201   4.495   1    58.71  ? 277 GLU B O   1 
ATOM   3291 C  CB  . GLU B 2 107 ? -1.492  6.586   4.158   1    62.22  ? 277 GLU B CB  1 
ATOM   3292 C  CG  . GLU B 2 107 ? -0.052  6.405   3.675   1    65.24  ? 277 GLU B CG  1 
ATOM   3293 C  CD  . GLU B 2 107 ? 0.23    5.016   3.089   1    82.66  ? 277 GLU B CD  1 
ATOM   3294 O  OE1 . GLU B 2 107 ? 0.736   4.971   1.946   1    88.36  ? 277 GLU B OE1 1 
ATOM   3295 O  OE2 . GLU B 2 107 ? -0.028  3.96    3.739   1    84.32  ? 277 GLU B OE2 1 
ATOM   3296 N  N   . PHE B 2 108 ? -3.963  7.587   5.987   1    52.95  ? 278 PHE B N   1 
ATOM   3297 C  CA  . PHE B 2 108 ? -5.324  8.052   6.229   1    52.5   ? 278 PHE B CA  1 
ATOM   3298 C  C   . PHE B 2 108 ? -5.315  9.464   6.843   1    55.43  ? 278 PHE B C   1 
ATOM   3299 O  O   . PHE B 2 108 ? -6.128  10.293  6.446   1    56.58  ? 278 PHE B O   1 
ATOM   3300 C  CB  . PHE B 2 108 ? -6.142  7.014   7.013   1    46.44  ? 278 PHE B CB  1 
ATOM   3301 C  CG  . PHE B 2 108 ? -6.567  5.843   6.146   1    47.69  ? 278 PHE B CG  1 
ATOM   3302 C  CD1 . PHE B 2 108 ? -7.595  5.989   5.221   1    46.7   ? 278 PHE B CD1 1 
ATOM   3303 C  CD2 . PHE B 2 108 ? -5.897  4.616   6.21    1    45.27  ? 278 PHE B CD2 1 
ATOM   3304 C  CE1 . PHE B 2 108 ? -7.947  4.921   4.401   1    45.7   ? 278 PHE B CE1 1 
ATOM   3305 C  CE2 . PHE B 2 108 ? -6.24   3.569   5.367   1    41.52  ? 278 PHE B CE2 1 
ATOM   3306 C  CZ  . PHE B 2 108 ? -7.273  3.715   4.483   1    42.19  ? 278 PHE B CZ  1 
ATOM   3307 N  N   . VAL B 2 109 ? -4.408  9.743   7.8     1    49.59  ? 279 VAL B N   1 
ATOM   3308 C  CA  . VAL B 2 109 ? -4.316  11.08   8.351   1    52.9   ? 279 VAL B CA  1 
ATOM   3309 C  C   . VAL B 2 109 ? -3.924  12.056  7.242   1    57.84  ? 279 VAL B C   1 
ATOM   3310 O  O   . VAL B 2 109 ? -4.453  13.163  7.179   1    63.67  ? 279 VAL B O   1 
ATOM   3311 C  CB  . VAL B 2 109 ? -3.359  11.178  9.554   1    52.04  ? 279 VAL B CB  1 
ATOM   3312 C  CG1 . VAL B 2 109 ? -3.192  12.618  10.024  1    48.4   ? 279 VAL B CG1 1 
ATOM   3313 C  CG2 . VAL B 2 109 ? -3.804  10.29   10.713  1    47.52  ? 279 VAL B CG2 1 
ATOM   3314 N  N   . TYR B 2 110 ? -2.997  11.633  6.378   1    58.24  ? 280 TYR B N   1 
ATOM   3315 C  CA  . TYR B 2 110 ? -2.481  12.478  5.315   1    65.42  ? 280 TYR B CA  1 
ATOM   3316 C  C   . TYR B 2 110 ? -3.595  12.913  4.346   1    71.86  ? 280 TYR B C   1 
ATOM   3317 O  O   . TYR B 2 110 ? -3.651  14.084  3.984   1    78.67  ? 280 TYR B O   1 
ATOM   3318 C  CB  . TYR B 2 110 ? -1.264  11.842  4.635   1    70.15  ? 280 TYR B CB  1 
ATOM   3319 C  CG  . TYR B 2 110 ? -0.702  12.641  3.463   1    78.17  ? 280 TYR B CG  1 
ATOM   3320 C  CD1 . TYR B 2 110 ? -0.003  13.833  3.669   1    84.78  ? 280 TYR B CD1 1 
ATOM   3321 C  CD2 . TYR B 2 110 ? -0.868  12.198  2.146   1    82.62  ? 280 TYR B CD2 1 
ATOM   3322 C  CE1 . TYR B 2 110 ? 0.51    14.559  2.603   1    89.33  ? 280 TYR B CE1 1 
ATOM   3323 C  CE2 . TYR B 2 110 ? -0.356  12.912  1.071   1    92.05  ? 280 TYR B CE2 1 
ATOM   3324 C  CZ  . TYR B 2 110 ? 0.344   14.093  1.302   1    95.83  ? 280 TYR B CZ  1 
ATOM   3325 O  OH  . TYR B 2 110 ? 0.84    14.805  0.236   1    86.03  ? 280 TYR B OH  1 
ATOM   3326 N  N   . ILE B 2 111 ? -4.501  12.008  3.938   1    69.83  ? 281 ILE B N   1 
ATOM   3327 C  CA  . ILE B 2 111 ? -5.497  12.337  2.918   1    67.88  ? 281 ILE B CA  1 
ATOM   3328 C  C   . ILE B 2 111 ? -6.572  13.291  3.438   1    63.83  ? 281 ILE B C   1 
ATOM   3329 O  O   . ILE B 2 111 ? -7.302  13.873  2.641   1    63.86  ? 281 ILE B O   1 
ATOM   3330 C  CB  . ILE B 2 111 ? -6.163  11.089  2.329   1    70.08  ? 281 ILE B CB  1 
ATOM   3331 C  CG1 . ILE B 2 111 ? -6.717  10.195  3.448   1    68.31  ? 281 ILE B CG1 1 
ATOM   3332 C  CG2 . ILE B 2 111 ? -5.185  10.374  1.395   1    71.69  ? 281 ILE B CG2 1 
ATOM   3333 C  CD1 . ILE B 2 111 ? -7.873  9.297   3.035   1    75.64  ? 281 ILE B CD1 1 
ATOM   3334 N  N   . THR B 2 112 ? -6.698  13.415  4.761   1    57.45  ? 282 THR B N   1 
ATOM   3335 C  CA  . THR B 2 112 ? -7.623  14.374  5.344   1    60.05  ? 282 THR B CA  1 
ATOM   3336 C  C   . THR B 2 112 ? -7.003  15.768  5.455   1    68.77  ? 282 THR B C   1 
ATOM   3337 O  O   . THR B 2 112 ? -7.603  16.617  6.113   1    67.76  ? 282 THR B O   1 
ATOM   3338 C  CB  . THR B 2 112 ? -8.056  13.91   6.734   1    62.46  ? 282 THR B CB  1 
ATOM   3339 O  OG1 . THR B 2 112 ? -6.875  13.922  7.535   1    68.89  ? 282 THR B OG1 1 
ATOM   3340 C  CG2 . THR B 2 112 ? -8.763  12.569  6.738   1    50.62  ? 282 THR B CG2 1 
ATOM   3341 N  N   . ASP B 2 113 ? -5.794  15.971  4.891   1    81.28  ? 283 ASP B N   1 
ATOM   3342 C  CA  . ASP B 2 113 ? -5.072  17.24   4.823   1    84.75  ? 283 ASP B CA  1 
ATOM   3343 C  C   . ASP B 2 113 ? -4.858  17.829  6.208   1    88.34  ? 283 ASP B C   1 
ATOM   3344 O  O   . ASP B 2 113 ? -5.023  19.031  6.402   1    95.02  ? 283 ASP B O   1 
ATOM   3345 C  CB  . ASP B 2 113 ? -5.732  18.222  3.868   1    92.7   ? 283 ASP B CB  1 
ATOM   3346 C  CG  . ASP B 2 113 ? -5.597  17.829  2.405   1    108.16 ? 283 ASP B CG  1 
ATOM   3347 O  OD1 . ASP B 2 113 ? -4.473  17.446  2.021   1    118.21 ? 283 ASP B OD1 1 
ATOM   3348 O  OD2 . ASP B 2 113 ? -6.599  17.913  1.659   1    112.69 ? 283 ASP B OD2 1 
ATOM   3349 N  N   . ASP B 2 114 ? -4.524  16.951  7.159   1    98.65  ? 284 ASP B N   1 
ATOM   3350 C  CA  . ASP B 2 114 ? -4.266  17.294  8.553   1    98.6   ? 284 ASP B CA  1 
ATOM   3351 C  C   . ASP B 2 114 ? -5.426  18.064  9.19    1    80.36  ? 284 ASP B C   1 
ATOM   3352 O  O   . ASP B 2 114 ? -5.21   18.861  10.096  1    74.53  ? 284 ASP B O   1 
ATOM   3353 C  CB  . ASP B 2 114 ? -2.893  17.933  8.7     1    110.32 ? 284 ASP B CB  1 
ATOM   3354 C  CG  . ASP B 2 114 ? -1.763  17.215  7.972   1    113.96 ? 284 ASP B CG  1 
ATOM   3355 O  OD1 . ASP B 2 114 ? -1.621  15.986  8.145   1    103.84 ? 284 ASP B OD1 1 
ATOM   3356 O  OD2 . ASP B 2 114 ? -1.019  17.896  7.238   1    119.59 ? 284 ASP B OD2 1 
ATOM   3357 N  N   . THR B 2 115 ? -6.659  17.787  8.743   1    74.81  ? 285 THR B N   1 
ATOM   3358 C  CA  . THR B 2 115 ? -7.871  18.214  9.434   1    76.18  ? 285 THR B CA  1 
ATOM   3359 C  C   . THR B 2 115 ? -7.947  17.52   10.802  1    73.89  ? 285 THR B C   1 
ATOM   3360 O  O   . THR B 2 115 ? -8.34   18.121  11.801  1    79.82  ? 285 THR B O   1 
ATOM   3361 C  CB  . THR B 2 115 ? -9.109  17.901  8.586   1    70.59  ? 285 THR B CB  1 
ATOM   3362 O  OG1 . THR B 2 115 ? -8.929  18.419  7.278   1    70.7   ? 285 THR B OG1 1 
ATOM   3363 C  CG2 . THR B 2 115 ? -10.382 18.52   9.133   1    65.72  ? 285 THR B CG2 1 
ATOM   3364 N  N   . TYR B 2 116 ? -7.576  16.236  10.825  1    64.18  ? 286 TYR B N   1 
ATOM   3365 C  CA  . TYR B 2 116 ? -7.616  15.408  12.018  1    58.93  ? 286 TYR B CA  1 
ATOM   3366 C  C   . TYR B 2 116 ? -6.22   14.903  12.341  1    57.56  ? 286 TYR B C   1 
ATOM   3367 O  O   . TYR B 2 116 ? -5.312  14.994  11.523  1    63.82  ? 286 TYR B O   1 
ATOM   3368 C  CB  . TYR B 2 116 ? -8.538  14.202  11.815  1    55.49  ? 286 TYR B CB  1 
ATOM   3369 C  CG  . TYR B 2 116 ? -9.893  14.604  11.245  1    58.58  ? 286 TYR B CG  1 
ATOM   3370 C  CD1 . TYR B 2 116 ? -10.787 15.35   12.014  1    58.84  ? 286 TYR B CD1 1 
ATOM   3371 C  CD2 . TYR B 2 116 ? -10.26  14.28   9.937   1    53.45  ? 286 TYR B CD2 1 
ATOM   3372 C  CE1 . TYR B 2 116 ? -12.011 15.755  11.514  1    51.03  ? 286 TYR B CE1 1 
ATOM   3373 C  CE2 . TYR B 2 116 ? -11.486 14.674  9.436   1    53.28  ? 286 TYR B CE2 1 
ATOM   3374 C  CZ  . TYR B 2 116 ? -12.358 15.413  10.229  1    49.94  ? 286 TYR B CZ  1 
ATOM   3375 O  OH  . TYR B 2 116 ? -13.591 15.786  9.795   1    48.57  ? 286 TYR B OH  1 
ATOM   3376 N  N   . THR B 2 117 ? -6.079  14.416  13.572  1    58.81  ? 287 THR B N   1 
ATOM   3377 C  CA  . THR B 2 117 ? -4.865  13.803  14.087  1    59.76  ? 287 THR B CA  1 
ATOM   3378 C  C   . THR B 2 117 ? -4.987  12.281  14.019  1    56.75  ? 287 THR B C   1 
ATOM   3379 O  O   . THR B 2 117 ? -6.088  11.739  14.028  1    54.69  ? 287 THR B O   1 
ATOM   3380 C  CB  . THR B 2 117 ? -4.644  14.222  15.54   1    58.53  ? 287 THR B CB  1 
ATOM   3381 O  OG1 . THR B 2 117 ? -5.815  13.835  16.253  1    61.68  ? 287 THR B OG1 1 
ATOM   3382 C  CG2 . THR B 2 117 ? -4.346  15.699  15.685  1    54.91  ? 287 THR B CG2 1 
ATOM   3383 N  N   . LYS B 2 118 ? -3.837  11.601  13.995  1    56.84  ? 288 LYS B N   1 
ATOM   3384 C  CA  . LYS B 2 118 ? -3.767  10.155  14.136  1    56.1   ? 288 LYS B CA  1 
ATOM   3385 C  C   . LYS B 2 118 ? -4.62   9.698   15.316  1    53.36  ? 288 LYS B C   1 
ATOM   3386 O  O   . LYS B 2 118 ? -5.387  8.748   15.187  1    51.99  ? 288 LYS B O   1 
ATOM   3387 C  CB  . LYS B 2 118 ? -2.311  9.725   14.346  1    62.81  ? 288 LYS B CB  1 
ATOM   3388 C  CG  . LYS B 2 118 ? -2.007  8.257   14.079  1    65.57  ? 288 LYS B CG  1 
ATOM   3389 C  CD  . LYS B 2 118 ? -0.662  7.803   14.63   1    74.87  ? 288 LYS B CD  1 
ATOM   3390 C  CE  . LYS B 2 118 ? -0.397  6.341   14.453  1    77.32  ? 288 LYS B CE  1 
ATOM   3391 N  NZ  . LYS B 2 118 ? 0.645   5.842   15.361  1    79.86  ? 288 LYS B NZ  1 
ATOM   3392 N  N   . LYS B 2 119 ? -4.514  10.393  16.452  1    56.67  ? 289 LYS B N   1 
ATOM   3393 C  CA  . LYS B 2 119 ? -5.24   10.014  17.659  1    61.12  ? 289 LYS B CA  1 
ATOM   3394 C  C   . LYS B 2 119 ? -6.755  10.038  17.439  1    58.49  ? 289 LYS B C   1 
ATOM   3395 O  O   . LYS B 2 119 ? -7.448  9.114   17.853  1    55.54  ? 289 LYS B O   1 
ATOM   3396 C  CB  . LYS B 2 119 ? -4.875  10.933  18.827  1    68.84  ? 289 LYS B CB  1 
ATOM   3397 C  CG  . LYS B 2 119 ? -5.211  10.344  20.177  1    79.13  ? 289 LYS B CG  1 
ATOM   3398 C  CD  . LYS B 2 119 ? -4.538  11.012  21.376  1    90.55  ? 289 LYS B CD  1 
ATOM   3399 C  CE  . LYS B 2 119 ? -5.235  12.251  21.896  1    97.14  ? 289 LYS B CE  1 
ATOM   3400 N  NZ  . LYS B 2 119 ? -6.516  11.917  22.534  1    104.84 ? 289 LYS B NZ  1 
ATOM   3401 N  N   . GLN B 2 120 ? -7.249  11.096  16.781  1    52.01  ? 290 GLN B N   1 
ATOM   3402 C  CA  . GLN B 2 120 ? -8.654  11.2    16.414  1    52.51  ? 290 GLN B CA  1 
ATOM   3403 C  C   . GLN B 2 120 ? -9.114  10.091  15.459  1    52.73  ? 290 GLN B C   1 
ATOM   3404 O  O   . GLN B 2 120 ? -10.257 9.635   15.525  1    52.74  ? 290 GLN B O   1 
ATOM   3405 C  CB  . GLN B 2 120 ? -8.929  12.533  15.728  1    54.42  ? 290 GLN B CB  1 
ATOM   3406 C  CG  . GLN B 2 120 ? -8.911  13.731  16.669  1    60.2   ? 290 GLN B CG  1 
ATOM   3407 C  CD  . GLN B 2 120 ? -9.286  15.013  15.954  1    67.13  ? 290 GLN B CD  1 
ATOM   3408 O  OE1 . GLN B 2 120 ? -8.614  15.421  14.995  1    68.61  ? 290 GLN B OE1 1 
ATOM   3409 N  NE2 . GLN B 2 120 ? -10.386 15.623  16.385  1    58.68  ? 290 GLN B NE2 1 
ATOM   3410 N  N   . VAL B 2 121 ? -8.267  9.705   14.502  1    50.27  ? 291 VAL B N   1 
ATOM   3411 C  CA  . VAL B 2 121 ? -8.643  8.652   13.582  1    47.22  ? 291 VAL B CA  1 
ATOM   3412 C  C   . VAL B 2 121 ? -8.781  7.334   14.347  1    46.46  ? 291 VAL B C   1 
ATOM   3413 O  O   . VAL B 2 121 ? -9.75   6.611   14.156  1    47.52  ? 291 VAL B O   1 
ATOM   3414 C  CB  . VAL B 2 121 ? -7.655  8.542   12.407  1    48.15  ? 291 VAL B CB  1 
ATOM   3415 C  CG1 . VAL B 2 121 ? -7.898  7.285   11.576  1    46.77  ? 291 VAL B CG1 1 
ATOM   3416 C  CG2 . VAL B 2 121 ? -7.737  9.765   11.514  1    49.59  ? 291 VAL B CG2 1 
ATOM   3417 N  N   . LEU B 2 122 ? -7.85   7.039   15.239  1    48.98  ? 292 LEU B N   1 
ATOM   3418 C  CA  . LEU B 2 122 ? -7.879  5.727   15.927  1    51.65  ? 292 LEU B CA  1 
ATOM   3419 C  C   . LEU B 2 122 ? -9.03   5.681   16.94   1    52.52  ? 292 LEU B C   1 
ATOM   3420 O  O   . LEU B 2 122 ? -9.555  4.588   17.18   1    56.14  ? 292 LEU B O   1 
ATOM   3421 C  CB  . LEU B 2 122 ? -6.516  5.494   16.57   1    53.02  ? 292 LEU B CB  1 
ATOM   3422 C  CG  . LEU B 2 122 ? -5.355  5.351   15.584  1    54.95  ? 292 LEU B CG  1 
ATOM   3423 C  CD1 . LEU B 2 122 ? -4.054  5.046   16.291  1    52.53  ? 292 LEU B CD1 1 
ATOM   3424 C  CD2 . LEU B 2 122 ? -5.679  4.285   14.558  1    50.01  ? 292 LEU B CD2 1 
ATOM   3425 N  N   . ARG B 2 123 ? -9.414  6.828   17.487  1    52.25  ? 293 ARG B N   1 
ATOM   3426 C  CA  . ARG B 2 123 ? -10.517 6.873   18.477  1    51.34  ? 293 ARG B CA  1 
ATOM   3427 C  C   . ARG B 2 123 ? -11.852 6.704   17.741  1    48.45  ? 293 ARG B C   1 
ATOM   3428 O  O   . ARG B 2 123 ? -12.737 6.045   18.294  1    47.09  ? 293 ARG B O   1 
ATOM   3429 C  CB  . ARG B 2 123 ? -10.414 8.159   19.3    1    51.8   ? 293 ARG B CB  1 
ATOM   3430 C  CG  . ARG B 2 123 ? -9.457  8.072   20.479  1    61.12  ? 293 ARG B CG  1 
ATOM   3431 C  CD  . ARG B 2 123 ? -9.782  9.112   21.535  1    75.18  ? 293 ARG B CD  1 
ATOM   3432 N  NE  . ARG B 2 123 ? -9.634  8.587   22.897  1    87.7   ? 293 ARG B NE  1 
ATOM   3433 C  CZ  . ARG B 2 123 ? -10.5   7.777   23.491  1    102.44 ? 293 ARG B CZ  1 
ATOM   3434 N  NH1 . ARG B 2 123 ? -11.792 7.902   23.257  1    104.75 ? 293 ARG B NH1 1 
ATOM   3435 N  NH2 . ARG B 2 123 ? -10.07  6.845   24.322  1    103.59 ? 293 ARG B NH2 1 
ATOM   3436 N  N   . MET B 2 124 ? -11.983 7.279   16.548  1    44.78  ? 294 MET B N   1 
ATOM   3437 C  CA  . MET B 2 124 ? -13.21  7.069   15.742  1    44.62  ? 294 MET B CA  1 
ATOM   3438 C  C   . MET B 2 124 ? -13.209 5.618   15.264  1    42.38  ? 294 MET B C   1 
ATOM   3439 O  O   . MET B 2 124 ? -14.289 5.029   15.194  1    46.76  ? 294 MET B O   1 
ATOM   3440 C  CB  . MET B 2 124 ? -13.272 8.022   14.547  1    45.26  ? 294 MET B CB  1 
ATOM   3441 C  CG  . MET B 2 124 ? -14.538 7.929   13.722  1    44.41  ? 294 MET B CG  1 
ATOM   3442 S  SD  . MET B 2 124 ? -16.027 8.374   14.632  1    47.64  ? 294 MET B SD  1 
ATOM   3443 C  CE  . MET B 2 124 ? -15.927 10.166  14.581  1    45.14  ? 294 MET B CE  1 
ATOM   3444 N  N   . GLU B 2 125 ? -12.056 5.028   14.979  1    39.15  ? 295 GLU B N   1 
ATOM   3445 C  CA  . GLU B 2 125 ? -12.057 3.594   14.597  1    39.71  ? 295 GLU B CA  1 
ATOM   3446 C  C   . GLU B 2 125 ? -12.734 2.801   15.716  1    42.13  ? 295 GLU B C   1 
ATOM   3447 O  O   . GLU B 2 125 ? -13.614 1.984   15.411  1    41.53  ? 295 GLU B O   1 
ATOM   3448 C  CB  . GLU B 2 125 ? -10.638 3.105   14.322  1    38.46  ? 295 GLU B CB  1 
ATOM   3449 C  CG  . GLU B 2 125 ? -10.532 1.592   14.168  1    37.24  ? 295 GLU B CG  1 
ATOM   3450 C  CD  . GLU B 2 125 ? -9.116  1.086   13.985  1    42.59  ? 295 GLU B CD  1 
ATOM   3451 O  OE1 . GLU B 2 125 ? -8.393  0.995   14.99   1    44.05  ? 295 GLU B OE1 1 
ATOM   3452 O  OE2 . GLU B 2 125 ? -8.738  0.78    12.842  1    46.11  ? 295 GLU B OE2 1 
ATOM   3453 N  N   . HIS B 2 126 ? -12.348 3.074   16.957  1    41.98  ? 296 HIS B N   1 
ATOM   3454 C  CA  . HIS B 2 126 ? -12.92  2.38    18.133  1    47.95  ? 296 HIS B CA  1 
ATOM   3455 C  C   . HIS B 2 126 ? -14.422 2.635   18.207  1    48.22  ? 296 HIS B C   1 
ATOM   3456 O  O   . HIS B 2 126 ? -15.181 1.684   18.438  1    51.53  ? 296 HIS B O   1 
ATOM   3457 C  CB  . HIS B 2 126 ? -12.247 2.928   19.388  1    59.99  ? 296 HIS B CB  1 
ATOM   3458 C  CG  . HIS B 2 126 ? -11.878 1.962   20.455  1    79.03  ? 296 HIS B CG  1 
ATOM   3459 N  ND1 . HIS B 2 126 ? -10.693 1.262   20.445  1    81.17  ? 296 HIS B ND1 1 
ATOM   3460 C  CD2 . HIS B 2 126 ? -12.499 1.635   21.592  1    95     ? 296 HIS B CD2 1 
ATOM   3461 C  CE1 . HIS B 2 126 ? -10.621 0.521   21.539  1    105.13 ? 296 HIS B CE1 1 
ATOM   3462 N  NE2 . HIS B 2 126 ? -11.71  0.728   22.248  1    121.1  ? 296 HIS B NE2 1 
ATOM   3463 N  N   . LEU B 2 127 ? -14.831 3.889   18.028  1    44.25  ? 297 LEU B N   1 
ATOM   3464 C  CA  . LEU B 2 127 ? -16.264 4.241   18.145  1    42.07  ? 297 LEU B CA  1 
ATOM   3465 C  C   . LEU B 2 127 ? -17.043 3.491   17.067  1    40.88  ? 297 LEU B C   1 
ATOM   3466 O  O   . LEU B 2 127 ? -18.044 2.854   17.392  1    39.8   ? 297 LEU B O   1 
ATOM   3467 C  CB  . LEU B 2 127 ? -16.463 5.748   18.033  1    42.42  ? 297 LEU B CB  1 
ATOM   3468 C  CG  . LEU B 2 127 ? -17.864 6.263   18.375  1    40.77  ? 297 LEU B CG  1 
ATOM   3469 C  CD1 . LEU B 2 127 ? -18.336 5.68    19.69   1    35.9   ? 297 LEU B CD1 1 
ATOM   3470 C  CD2 . LEU B 2 127 ? -17.894 7.777   18.419  1    40.01  ? 297 LEU B CD2 1 
ATOM   3471 N  N   . VAL B 2 128 ? -16.571 3.572   15.832  1    40.54  ? 298 VAL B N   1 
ATOM   3472 C  CA  . VAL B 2 128 ? -17.243 2.839   14.767  1    40.85  ? 298 VAL B CA  1 
ATOM   3473 C  C   . VAL B 2 128 ? -17.34  1.351   15.115  1    43.71  ? 298 VAL B C   1 
ATOM   3474 O  O   . VAL B 2 128 ? -18.39  0.73    14.927  1    51.33  ? 298 VAL B O   1 
ATOM   3475 C  CB  . VAL B 2 128 ? -16.601 3.049   13.39   1    39.44  ? 298 VAL B CB  1 
ATOM   3476 C  CG1 . VAL B 2 128 ? -17.276 2.182   12.35   1    39.37  ? 298 VAL B CG1 1 
ATOM   3477 C  CG2 . VAL B 2 128 ? -16.665 4.498   12.958  1    43.02  ? 298 VAL B CG2 1 
ATOM   3478 N  N   . LEU B 2 129 ? -16.25  0.766   15.619  1    42.63  ? 299 LEU B N   1 
ATOM   3479 C  CA  . LEU B 2 129 ? -16.298 -0.633  16.006  1    41.05  ? 299 LEU B CA  1 
ATOM   3480 C  C   . LEU B 2 129 ? -17.337 -0.867  17.105  1    41.17  ? 299 LEU B C   1 
ATOM   3481 O  O   . LEU B 2 129 ? -18.059 -1.859  17.08   1    42.4   ? 299 LEU B O   1 
ATOM   3482 C  CB  . LEU B 2 129 ? -14.914 -1.143  16.4    1    43.07  ? 299 LEU B CB  1 
ATOM   3483 C  CG  . LEU B 2 129 ? -13.906 -1.33   15.264  1    41.01  ? 299 LEU B CG  1 
ATOM   3484 C  CD1 . LEU B 2 129 ? -12.568 -1.701  15.842  1    40.44  ? 299 LEU B CD1 1 
ATOM   3485 C  CD2 . LEU B 2 129 ? -14.372 -2.388  14.303  1    37.3   ? 299 LEU B CD2 1 
ATOM   3486 N  N   . LYS B 2 130 ? -17.428 0.043   18.072  1    43.65  ? 300 LYS B N   1 
ATOM   3487 C  CA  . LYS B 2 130 ? -18.399 -0.117  19.147  1    46.72  ? 300 LYS B CA  1 
ATOM   3488 C  C   . LYS B 2 130 ? -19.791 -0.081  18.512  1    45.86  ? 300 LYS B C   1 
ATOM   3489 O  O   . LYS B 2 130 ? -20.552 -1.033  18.661  1    47.12  ? 300 LYS B O   1 
ATOM   3490 C  CB  . LYS B 2 130 ? -18.169 0.88    20.301  1    53.24  ? 300 LYS B CB  1 
ATOM   3491 C  CG  . LYS B 2 130 ? -19.298 0.97    21.345  1    66.56  ? 300 LYS B CG  1 
ATOM   3492 C  CD  . LYS B 2 130 ? -19.491 2.223   22.208  1    66.48  ? 300 LYS B CD  1 
ATOM   3493 C  CE  . LYS B 2 130 ? -20.898 2.292   22.739  1    61.71  ? 300 LYS B CE  1 
ATOM   3494 N  NZ  . LYS B 2 130 ? -21.104 3.345   23.735  1    59.95  ? 300 LYS B NZ  1 
ATOM   3495 N  N   . VAL B 2 131 ? -20.075 0.978   17.734  1    41.86  ? 301 VAL B N   1 
ATOM   3496 C  CA  . VAL B 2 131 ? -21.397 1.23    17.177  1    42.5   ? 301 VAL B CA  1 
ATOM   3497 C  C   . VAL B 2 131 ? -21.84  0.046   16.308  1    41.76  ? 301 VAL B C   1 
ATOM   3498 O  O   . VAL B 2 131 ? -22.977 -0.381  16.394  1    45.06  ? 301 VAL B O   1 
ATOM   3499 C  CB  . VAL B 2 131 ? -21.433 2.596   16.441  1    41.89  ? 301 VAL B CB  1 
ATOM   3500 C  CG1 . VAL B 2 131 ? -22.661 2.781   15.545  1    36.03  ? 301 VAL B CG1 1 
ATOM   3501 C  CG2 . VAL B 2 131 ? -21.294 3.758   17.435  1    39.54  ? 301 VAL B CG2 1 
ATOM   3502 N  N   . LEU B 2 132 ? -20.937 -0.517  15.496  1    41.74  ? 302 LEU B N   1 
ATOM   3503 C  CA  . LEU B 2 132 ? -21.29  -1.6    14.592  1    39.57  ? 302 LEU B CA  1 
ATOM   3504 C  C   . LEU B 2 132 ? -21.211 -2.951  15.302  1    45.46  ? 302 LEU B C   1 
ATOM   3505 O  O   . LEU B 2 132 ? -21.546 -3.966  14.693  1    44.37  ? 302 LEU B O   1 
ATOM   3506 C  CB  . LEU B 2 132 ? -20.345 -1.56   13.396  1    34.3   ? 302 LEU B CB  1 
ATOM   3507 C  CG  . LEU B 2 132 ? -20.453 -0.3    12.544  1    35.34  ? 302 LEU B CG  1 
ATOM   3508 C  CD1 . LEU B 2 132 ? -19.563 -0.413  11.299  1    36.24  ? 302 LEU B CD1 1 
ATOM   3509 C  CD2 . LEU B 2 132 ? -21.885 0.056   12.152  1    31.54  ? 302 LEU B CD2 1 
ATOM   3510 N  N   . ALA B 2 133 ? -20.746 -2.949  16.573  1    43.03  ? 303 ALA B N   1 
ATOM   3511 C  CA  . ALA B 2 133 ? -20.454 -4.165  17.324  1    44.52  ? 303 ALA B CA  1 
ATOM   3512 C  C   . ALA B 2 133 ? -19.592 -5.14   16.51   1    43.23  ? 303 ALA B C   1 
ATOM   3513 O  O   . ALA B 2 133 ? -19.838 -6.349  16.552  1    39.9   ? 303 ALA B O   1 
ATOM   3514 C  CB  . ALA B 2 133 ? -21.723 -4.796  17.85   1    36.41  ? 303 ALA B CB  1 
ATOM   3515 N  N   . PHE B 2 134 ? -18.619 -4.605  15.767  1    38.37  ? 304 PHE B N   1 
ATOM   3516 C  CA  . PHE B 2 134 ? -17.651 -5.409  14.968  1    44.13  ? 304 PHE B CA  1 
ATOM   3517 C  C   . PHE B 2 134 ? -18.339 -6.215  13.861  1    46.21  ? 304 PHE B C   1 
ATOM   3518 O  O   . PHE B 2 134 ? -17.71  -7.131  13.34   1    44.66  ? 304 PHE B O   1 
ATOM   3519 C  CB  . PHE B 2 134 ? -16.782 -6.315  15.85   1    42.26  ? 304 PHE B CB  1 
ATOM   3520 C  CG  . PHE B 2 134 ? -15.709 -5.65   16.699  1    46.47  ? 304 PHE B CG  1 
ATOM   3521 C  CD1 . PHE B 2 134 ? -16.019 -5.087  17.929  1    50.08  ? 304 PHE B CD1 1 
ATOM   3522 C  CD2 . PHE B 2 134 ? -14.386 -5.622  16.278  1    46.83  ? 304 PHE B CD2 1 
ATOM   3523 C  CE1 . PHE B 2 134 ? -15.037 -4.493  18.702  1    51.53  ? 304 PHE B CE1 1 
ATOM   3524 C  CE2 . PHE B 2 134 ? -13.409 -5.029  17.058  1    43.57  ? 304 PHE B CE2 1 
ATOM   3525 C  CZ  . PHE B 2 134 ? -13.736 -4.468  18.266  1    51.32  ? 304 PHE B CZ  1 
ATOM   3526 N  N   . ASP B 2 135 ? -19.565 -5.864  13.488  1    49.08  ? 305 ASP B N   1 
ATOM   3527 C  CA  . ASP B 2 135 ? -20.249 -6.565  12.365  1    51.99  ? 305 ASP B CA  1 
ATOM   3528 C  C   . ASP B 2 135 ? -19.801 -5.933  11.05   1    42.31  ? 305 ASP B C   1 
ATOM   3529 O  O   . ASP B 2 135 ? -20.527 -5.077  10.543  1    40.59  ? 305 ASP B O   1 
ATOM   3530 C  CB  . ASP B 2 135 ? -21.748 -6.633  12.587  1    59.41  ? 305 ASP B CB  1 
ATOM   3531 C  CG  . ASP B 2 135 ? -22.198 -7.713  13.556  1    83.07  ? 305 ASP B CG  1 
ATOM   3532 O  OD1 . ASP B 2 135 ? -22.196 -8.89   13.152  1    98.09  ? 305 ASP B OD1 1 
ATOM   3533 O  OD2 . ASP B 2 135 ? -22.547 -7.367  14.7    1    88.71  ? 305 ASP B OD2 1 
ATOM   3534 N  N   . LEU B 2 136 ? -18.667 -6.381  10.515  1    40.25  ? 306 LEU B N   1 
ATOM   3535 C  CA  . LEU B 2 136 ? -18.072 -5.737  9.318   1    39.55  ? 306 LEU B CA  1 
ATOM   3536 C  C   . LEU B 2 136 ? -18.154 -6.633  8.073   1    38.65  ? 306 LEU B C   1 
ATOM   3537 O  O   . LEU B 2 136 ? -17.921 -6.116  6.979   1    37.51  ? 306 LEU B O   1 
ATOM   3538 C  CB  . LEU B 2 136 ? -16.636 -5.396  9.705   1    39.89  ? 306 LEU B CB  1 
ATOM   3539 C  CG  . LEU B 2 136 ? -16.44  -4.448  10.891  1    42.23  ? 306 LEU B CG  1 
ATOM   3540 C  CD1 . LEU B 2 136 ? -15.015 -3.938  10.876  1    43.58  ? 306 LEU B CD1 1 
ATOM   3541 C  CD2 . LEU B 2 136 ? -17.402 -3.284  10.856  1    38.15  ? 306 LEU B CD2 1 
ATOM   3542 N  N   . ALA B 2 137 ? -18.46  -7.919  8.23    1    41.52  ? 307 ALA B N   1 
ATOM   3543 C  CA  . ALA B 2 137 ? -18.662 -8.779  7.057   1    39.41  ? 307 ALA B CA  1 
ATOM   3544 C  C   . ALA B 2 137 ? -20.03  -8.547  6.396   1    35.17  ? 307 ALA B C   1 
ATOM   3545 O  O   . ALA B 2 137 ? -20.86  -9.437  6.328   1    34.93  ? 307 ALA B O   1 
ATOM   3546 C  CB  . ALA B 2 137 ? -18.516 -10.225 7.467   1    36.6   ? 307 ALA B CB  1 
ATOM   3547 N  N   . ALA B 2 138 ? -20.265 -7.335  5.912   1    32.67  ? 308 ALA B N   1 
ATOM   3548 C  CA  . ALA B 2 138 ? -21.537 -6.928  5.351   1    37.47  ? 308 ALA B CA  1 
ATOM   3549 C  C   . ALA B 2 138 ? -21.601 -7.296  3.875   1    36.61  ? 308 ALA B C   1 
ATOM   3550 O  O   . ALA B 2 138 ? -20.629 -7.154  3.162   1    34.16  ? 308 ALA B O   1 
ATOM   3551 C  CB  . ALA B 2 138 ? -21.69  -5.417  5.477   1    36.31  ? 308 ALA B CB  1 
ATOM   3552 N  N   . PRO B 2 139 ? -22.761 -7.765  3.385   1    39.35  ? 309 PRO B N   1 
ATOM   3553 C  CA  . PRO B 2 139 ? -22.989 -7.91   1.956   1    40.02  ? 309 PRO B CA  1 
ATOM   3554 C  C   . PRO B 2 139 ? -22.962 -6.55   1.273   1    39.72  ? 309 PRO B C   1 
ATOM   3555 O  O   . PRO B 2 139 ? -23.53  -5.573  1.775   1    48.53  ? 309 PRO B O   1 
ATOM   3556 C  CB  . PRO B 2 139 ? -24.381 -8.562  1.857   1    38.63  ? 309 PRO B CB  1 
ATOM   3557 C  CG  . PRO B 2 139 ? -24.611 -9.138  3.233   1    48.64  ? 309 PRO B CG  1 
ATOM   3558 C  CD  . PRO B 2 139 ? -23.914 -8.191  4.195   1    43.86  ? 309 PRO B CD  1 
ATOM   3559 N  N   . THR B 2 140 ? -22.307 -6.532  0.109   1    38.67  ? 310 THR B N   1 
ATOM   3560 C  CA  . THR B 2 140 ? -22.245 -5.397  -0.798  1    40.84  ? 310 THR B CA  1 
ATOM   3561 C  C   . THR B 2 140 ? -22.894 -5.711  -2.141  1    38.68  ? 310 THR B C   1 
ATOM   3562 O  O   . THR B 2 140 ? -23.084 -6.866  -2.51   1    42.02  ? 310 THR B O   1 
ATOM   3563 C  CB  . THR B 2 140 ? -20.786 -5.02   -1.043  1    37.93  ? 310 THR B CB  1 
ATOM   3564 O  OG1 . THR B 2 140 ? -20.168 -6.105  -1.75   1    39.23  ? 310 THR B OG1 1 
ATOM   3565 C  CG2 . THR B 2 140 ? -20.079 -4.699  0.262   1    31.6   ? 310 THR B CG2 1 
ATOM   3566 N  N   . ILE B 2 141 ? -23.143 -4.644  -2.897  1    38.06  ? 311 ILE B N   1 
ATOM   3567 C  CA  . ILE B 2 141 ? -23.571 -4.739  -4.279  1    36.66  ? 311 ILE B CA  1 
ATOM   3568 C  C   . ILE B 2 141 ? -22.635 -5.68   -5.022  1    45.21  ? 311 ILE B C   1 
ATOM   3569 O  O   . ILE B 2 141 ? -23.109 -6.5    -5.81   1    54.91  ? 311 ILE B O   1 
ATOM   3570 C  CB  . ILE B 2 141 ? -23.615 -3.34   -4.919  1    37.55  ? 311 ILE B CB  1 
ATOM   3571 C  CG1 . ILE B 2 141 ? -24.75  -2.485  -4.308  1    35.63  ? 311 ILE B CG1 1 
ATOM   3572 C  CG2 . ILE B 2 141 ? -23.71  -3.404  -6.446  1    33.89  ? 311 ILE B CG2 1 
ATOM   3573 C  CD1 . ILE B 2 141 ? -24.683 -0.999  -4.645  1    33.76  ? 311 ILE B CD1 1 
ATOM   3574 N  N   . ASN B 2 142 ? -21.322 -5.555  -4.782  1    43.77  ? 312 ASN B N   1 
ATOM   3575 C  CA  . ASN B 2 142 ? -20.322 -6.258  -5.574  1    45.14  ? 312 ASN B CA  1 
ATOM   3576 C  C   . ASN B 2 142 ? -20.374 -7.764  -5.341  1    45.12  ? 312 ASN B C   1 
ATOM   3577 O  O   . ASN B 2 142 ? -20.17  -8.552  -6.273  1    46.96  ? 312 ASN B O   1 
ATOM   3578 C  CB  . ASN B 2 142 ? -18.911 -5.727  -5.353  1    46.52  ? 312 ASN B CB  1 
ATOM   3579 C  CG  . ASN B 2 142 ? -18.638 -4.531  -6.234  1    57.31  ? 312 ASN B CG  1 
ATOM   3580 O  OD1 . ASN B 2 142 ? -19.529 -3.718  -6.544  1    68.61  ? 312 ASN B OD1 1 
ATOM   3581 N  ND2 . ASN B 2 142 ? -17.402 -4.423  -6.674  1    58.33  ? 312 ASN B ND2 1 
ATOM   3582 N  N   . GLN B 2 143 ? -20.634 -8.157  -4.094  1    43.5   ? 313 GLN B N   1 
ATOM   3583 C  CA  . GLN B 2 143 ? -20.694 -9.573  -3.769  1    43.26  ? 313 GLN B CA  1 
ATOM   3584 C  C   . GLN B 2 143 ? -21.818 -10.259 -4.542  1    42.41  ? 313 GLN B C   1 
ATOM   3585 O  O   . GLN B 2 143 ? -21.703 -11.442 -4.847  1    48.58  ? 313 GLN B O   1 
ATOM   3586 C  CB  . GLN B 2 143 ? -20.84  -9.735  -2.259  1    42     ? 313 GLN B CB  1 
ATOM   3587 C  CG  . GLN B 2 143 ? -19.533 -9.5    -1.499  1    38.4   ? 313 GLN B CG  1 
ATOM   3588 C  CD  . GLN B 2 143 ? -19.738 -9.586  0.005   1    37.1   ? 313 GLN B CD  1 
ATOM   3589 O  OE1 . GLN B 2 143 ? -20.256 -10.581 0.538   1    33.77  ? 313 GLN B OE1 1 
ATOM   3590 N  NE2 . GLN B 2 143 ? -19.349 -8.522  0.701   1    32.65  ? 313 GLN B NE2 1 
ATOM   3591 N  N   . PHE B 2 144 ? -22.906 -9.518  -4.823  1    38.28  ? 314 PHE B N   1 
ATOM   3592 C  CA  . PHE B 2 144 ? -24.033 -10.009 -5.595  1    34.71  ? 314 PHE B CA  1 
ATOM   3593 C  C   . PHE B 2 144 ? -23.721 -9.958  -7.083  1    35.2   ? 314 PHE B C   1 
ATOM   3594 O  O   . PHE B 2 144 ? -23.885 -10.974 -7.763  1    39.22  ? 314 PHE B O   1 
ATOM   3595 C  CB  . PHE B 2 144 ? -25.308 -9.235  -5.292  1    33.53  ? 314 PHE B CB  1 
ATOM   3596 C  CG  . PHE B 2 144 ? -25.891 -9.6    -3.943  1    34.18  ? 314 PHE B CG  1 
ATOM   3597 C  CD1 . PHE B 2 144 ? -26.526 -10.834 -3.753  1    36.66  ? 314 PHE B CD1 1 
ATOM   3598 C  CD2 . PHE B 2 144 ? -25.798 -8.718  -2.877  1    33.62  ? 314 PHE B CD2 1 
ATOM   3599 C  CE1 . PHE B 2 144 ? -27.06  -11.173 -2.515  1    34.54  ? 314 PHE B CE1 1 
ATOM   3600 C  CE2 . PHE B 2 144 ? -26.343 -9.062  -1.638  1    34.74  ? 314 PHE B CE2 1 
ATOM   3601 C  CZ  . PHE B 2 144 ? -26.992 -10.275 -1.465  1    34.15  ? 314 PHE B CZ  1 
ATOM   3602 N  N   . LEU B 2 145 ? -23.262 -8.794  -7.563  1    34.68  ? 315 LEU B N   1 
ATOM   3603 C  CA  . LEU B 2 145 ? -22.889 -8.611  -8.966  1    38.73  ? 315 LEU B CA  1 
ATOM   3604 C  C   . LEU B 2 145 ? -22.027 -9.761  -9.498  1    38.77  ? 315 LEU B C   1 
ATOM   3605 O  O   . LEU B 2 145 ? -22.295 -10.257 -10.591 1    38.1   ? 315 LEU B O   1 
ATOM   3606 C  CB  . LEU B 2 145 ? -22.187 -7.278  -9.195  1    36.03  ? 315 LEU B CB  1 
ATOM   3607 C  CG  . LEU B 2 145 ? -23.081 -6.062  -9.44   1    35.91  ? 315 LEU B CG  1 
ATOM   3608 C  CD1 . LEU B 2 145 ? -22.207 -4.859  -9.735  1    36.37  ? 315 LEU B CD1 1 
ATOM   3609 C  CD2 . LEU B 2 145 ? -24.058 -6.269  -10.555 1    33.31  ? 315 LEU B CD2 1 
ATOM   3610 N  N   . THR B 2 146 ? -20.989 -10.147 -8.737  1    36.68  ? 316 THR B N   1 
ATOM   3611 C  CA  . THR B 2 146 ? -20.003 -11.102 -9.212  1    39.26  ? 316 THR B CA  1 
ATOM   3612 C  C   . THR B 2 146 ? -20.666 -12.46  -9.415  1    42.5   ? 316 THR B C   1 
ATOM   3613 O  O   . THR B 2 146 ? -20.295 -13.211 -10.323 1    48.93  ? 316 THR B O   1 
ATOM   3614 C  CB  . THR B 2 146 ? -18.76  -11.193 -8.321  1    38.07  ? 316 THR B CB  1 
ATOM   3615 O  OG1 . THR B 2 146 ? -19.207 -11.618 -7.036  1    42.49  ? 316 THR B OG1 1 
ATOM   3616 C  CG2 . THR B 2 146 ? -17.978 -9.893  -8.245  1    33.87  ? 316 THR B CG2 1 
ATOM   3617 N  N   . GLN B 2 147 ? -21.663 -12.762 -8.578  1    43.73  ? 317 GLN B N   1 
ATOM   3618 C  CA  . GLN B 2 147 ? -22.422 -14.001 -8.728  1    44.3   ? 317 GLN B CA  1 
ATOM   3619 C  C   . GLN B 2 147 ? -23.358 -13.933 -9.93   1    42.99  ? 317 GLN B C   1 
ATOM   3620 O  O   . GLN B 2 147 ? -23.523 -14.924 -10.646 1    44.79  ? 317 GLN B O   1 
ATOM   3621 C  CB  . GLN B 2 147 ? -23.24  -14.254 -7.467  1    41.19  ? 317 GLN B CB  1 
ATOM   3622 C  CG  . GLN B 2 147 ? -22.377 -14.717 -6.322  1    38.29  ? 317 GLN B CG  1 
ATOM   3623 C  CD  . GLN B 2 147 ? -23.182 -15.104 -5.117  1    42.65  ? 317 GLN B CD  1 
ATOM   3624 O  OE1 . GLN B 2 147 ? -22.759 -14.813 -3.992  1    50.12  ? 317 GLN B OE1 1 
ATOM   3625 N  NE2 . GLN B 2 147 ? -24.303 -15.788 -5.33   1    38.38  ? 317 GLN B NE2 1 
ATOM   3626 N  N   . TYR B 2 148 ? -23.996 -12.772 -10.104 1    40.99  ? 318 TYR B N   1 
ATOM   3627 C  CA  . TYR B 2 148 ? -24.881 -12.557 -11.239 1    44.91  ? 318 TYR B CA  1 
ATOM   3628 C  C   . TYR B 2 148 ? -24.094 -12.697 -12.549 1    46.5   ? 318 TYR B C   1 
ATOM   3629 O  O   . TYR B 2 148 ? -24.609 -13.21  -13.552 1    41.38  ? 318 TYR B O   1 
ATOM   3630 C  CB  . TYR B 2 148 ? -25.564 -11.187 -11.136 1    44.78  ? 318 TYR B CB  1 
ATOM   3631 C  CG  . TYR B 2 148 ? -26.471 -10.944 -9.933  1    42.62  ? 318 TYR B CG  1 
ATOM   3632 C  CD1 . TYR B 2 148 ? -26.832 -11.96  -9.056  1    40.03  ? 318 TYR B CD1 1 
ATOM   3633 C  CD2 . TYR B 2 148 ? -26.984 -9.682  -9.691  1    43.12  ? 318 TYR B CD2 1 
ATOM   3634 C  CE1 . TYR B 2 148 ? -27.682 -11.715 -7.993  1    40.78  ? 318 TYR B CE1 1 
ATOM   3635 C  CE2 . TYR B 2 148 ? -27.842 -9.429  -8.633  1    42.2   ? 318 TYR B CE2 1 
ATOM   3636 C  CZ  . TYR B 2 148 ? -28.195 -10.447 -7.772  1    40.92  ? 318 TYR B CZ  1 
ATOM   3637 O  OH  . TYR B 2 148 ? -29.041 -10.181 -6.722  1    39.04  ? 318 TYR B OH  1 
ATOM   3638 N  N   . PHE B 2 149 ? -22.827 -12.264 -12.53  1    44.15  ? 319 PHE B N   1 
ATOM   3639 C  CA  . PHE B 2 149 ? -21.969 -12.293 -13.704 1    46.86  ? 319 PHE B CA  1 
ATOM   3640 C  C   . PHE B 2 149 ? -21.776 -13.725 -14.224 1    49.53  ? 319 PHE B C   1 
ATOM   3641 O  O   . PHE B 2 149 ? -21.614 -13.929 -15.432 1    48.41  ? 319 PHE B O   1 
ATOM   3642 C  CB  . PHE B 2 149 ? -20.623 -11.657 -13.372 1    42.68  ? 319 PHE B CB  1 
ATOM   3643 C  CG  . PHE B 2 149 ? -20.599 -10.149 -13.21  1    44.54  ? 319 PHE B CG  1 
ATOM   3644 C  CD1 . PHE B 2 149 ? -21.698 -9.364  -13.547 1    43.54  ? 319 PHE B CD1 1 
ATOM   3645 C  CD2 . PHE B 2 149 ? -19.45  -9.517  -12.731 1    42.44  ? 319 PHE B CD2 1 
ATOM   3646 C  CE1 . PHE B 2 149 ? -21.637 -7.984  -13.396 1    44.68  ? 319 PHE B CE1 1 
ATOM   3647 C  CE2 . PHE B 2 149 ? -19.392 -8.14   -12.592 1    39.93  ? 319 PHE B CE2 1 
ATOM   3648 C  CZ  . PHE B 2 149 ? -20.478 -7.375  -12.931 1    45.03  ? 319 PHE B CZ  1 
ATOM   3649 N  N   . LEU B 2 150 ? -21.805 -14.714 -13.318 1    47.55  ? 320 LEU B N   1 
ATOM   3650 C  CA  . LEU B 2 150 ? -21.66  -16.118 -13.679 1    48.27  ? 320 LEU B CA  1 
ATOM   3651 C  C   . LEU B 2 150 ? -22.81  -16.616 -14.566 1    50.93  ? 320 LEU B C   1 
ATOM   3652 O  O   . LEU B 2 150 ? -22.763 -17.753 -15.043 1    52.28  ? 320 LEU B O   1 
ATOM   3653 C  CB  . LEU B 2 150 ? -21.535 -16.954 -12.41  1    44.57  ? 320 LEU B CB  1 
ATOM   3654 C  CG  . LEU B 2 150 ? -20.292 -16.661 -11.564 1    47.86  ? 320 LEU B CG  1 
ATOM   3655 C  CD1 . LEU B 2 150 ? -20.278 -17.493 -10.28  1    38.43  ? 320 LEU B CD1 1 
ATOM   3656 C  CD2 . LEU B 2 150 ? -19.005 -16.862 -12.41  1    44.38  ? 320 LEU B CD2 1 
ATOM   3657 N  N   . HIS B 2 151 ? -23.833 -15.778 -14.783 1    48.39  ? 321 HIS B N   1 
ATOM   3658 C  CA  . HIS B 2 151 ? -24.99  -16.162 -15.576 1    51.65  ? 321 HIS B CA  1 
ATOM   3659 C  C   . HIS B 2 151 ? -24.929 -15.57  -16.993 1    55.95  ? 321 HIS B C   1 
ATOM   3660 O  O   . HIS B 2 151 ? -25.873 -15.739 -17.768 1    62.64  ? 321 HIS B O   1 
ATOM   3661 C  CB  . HIS B 2 151 ? -26.279 -15.764 -14.84  1    51.09  ? 321 HIS B CB  1 
ATOM   3662 C  CG  . HIS B 2 151 ? -26.56  -16.601 -13.647 1    54.3   ? 321 HIS B CG  1 
ATOM   3663 N  ND1 . HIS B 2 151 ? -27.621 -17.484 -13.607 1    52.95  ? 321 HIS B ND1 1 
ATOM   3664 C  CD2 . HIS B 2 151 ? -25.912 -16.716 -12.463 1    50     ? 321 HIS B CD2 1 
ATOM   3665 C  CE1 . HIS B 2 151 ? -27.598 -18.117 -12.436 1    50.04  ? 321 HIS B CE1 1 
ATOM   3666 N  NE2 . HIS B 2 151 ? -26.562 -17.681 -11.739 1    49.07  ? 321 HIS B NE2 1 
ATOM   3667 N  N   . GLN B 2 152 ? -23.85  -14.844 -17.318 1    55.45  ? 322 GLN B N   1 
ATOM   3668 C  CA  . GLN B 2 152 ? -23.68  -14.277 -18.645 1    62.29  ? 322 GLN B CA  1 
ATOM   3669 C  C   . GLN B 2 152 ? -23.33  -15.419 -19.59  1    72.01  ? 322 GLN B C   1 
ATOM   3670 O  O   . GLN B 2 152 ? -22.545 -16.304 -19.221 1    66.75  ? 322 GLN B O   1 
ATOM   3671 C  CB  . GLN B 2 152 ? -22.487 -13.334 -18.755 1    61.19  ? 322 GLN B CB  1 
ATOM   3672 C  CG  . GLN B 2 152 ? -22.625 -12.023 -18.006 1    69.02  ? 322 GLN B CG  1 
ATOM   3673 C  CD  . GLN B 2 152 ? -21.328 -11.238 -17.991 1    76.55  ? 322 GLN B CD  1 
ATOM   3674 O  OE1 . GLN B 2 152 ? -21.171 -10.284 -18.769 1    74     ? 322 GLN B OE1 1 
ATOM   3675 N  NE2 . GLN B 2 152 ? -20.378 -11.657 -17.154 1    58.9   ? 322 GLN B NE2 1 
ATOM   3676 N  N   . GLN B 2 153 ? -23.893 -15.336 -20.805 1    77.59  ? 323 GLN B N   1 
ATOM   3677 C  CA  . GLN B 2 153 ? -23.822 -16.377 -21.819 1    92.55  ? 323 GLN B CA  1 
ATOM   3678 C  C   . GLN B 2 153 ? -23.45  -15.73  -23.162 1    95.26  ? 323 GLN B C   1 
ATOM   3679 O  O   . GLN B 2 153 ? -24.346 -15.381 -23.942 1    90.46  ? 323 GLN B O   1 
ATOM   3680 C  CB  . GLN B 2 153 ? -25.211 -17.022 -21.876 1    100.81 ? 323 GLN B CB  1 
ATOM   3681 C  CG  . GLN B 2 153 ? -25.298 -18.284 -22.733 1    125.24 ? 323 GLN B CG  1 
ATOM   3682 C  CD  . GLN B 2 153 ? -24.72  -19.506 -22.049 1    132.7  ? 323 GLN B CD  1 
ATOM   3683 O  OE1 . GLN B 2 153 ? -25.055 -19.804 -20.896 1    132.83 ? 323 GLN B OE1 1 
ATOM   3684 N  NE2 . GLN B 2 153 ? -23.828 -20.205 -22.74  1    116.84 ? 323 GLN B NE2 1 
ATOM   3685 N  N   . PRO B 2 154 ? -22.144 -15.474 -23.476 1    87.26  ? 324 PRO B N   1 
ATOM   3686 C  CA  . PRO B 2 154 ? -20.999 -15.74  -22.586 1    78.73  ? 324 PRO B CA  1 
ATOM   3687 C  C   . PRO B 2 154 ? -20.55  -14.474 -21.844 1    72.04  ? 324 PRO B C   1 
ATOM   3688 O  O   . PRO B 2 154 ? -21.202 -13.427 -21.956 1    67.95  ? 324 PRO B O   1 
ATOM   3689 C  CB  . PRO B 2 154 ? -19.95  -16.147 -23.632 1    73.15  ? 324 PRO B CB  1 
ATOM   3690 C  CG  . PRO B 2 154 ? -20.203 -15.173 -24.769 1    69.56  ? 324 PRO B CG  1 
ATOM   3691 C  CD  . PRO B 2 154 ? -21.696 -14.837 -24.729 1    73.57  ? 324 PRO B CD  1 
ATOM   3692 N  N   . ALA B 2 155 ? -19.424 -14.574 -21.112 1    62.18  ? 325 ALA B N   1 
ATOM   3693 C  CA  . ALA B 2 155 ? -18.945 -13.464 -20.3   1    56.96  ? 325 ALA B CA  1 
ATOM   3694 C  C   . ALA B 2 155 ? -18.63  -12.266 -21.19  1    62.41  ? 325 ALA B C   1 
ATOM   3695 O  O   . ALA B 2 155 ? -18.136 -12.424 -22.311 1    66.47  ? 325 ALA B O   1 
ATOM   3696 C  CB  . ALA B 2 155 ? -17.729 -13.881 -19.536 1    51.09  ? 325 ALA B CB  1 
ATOM   3697 N  N   . ASN B 2 156 ? -18.915 -11.062 -20.681 1    56.78  ? 326 ASN B N   1 
ATOM   3698 C  CA  . ASN B 2 156 ? -18.693 -9.845  -21.444 1    55.54  ? 326 ASN B CA  1 
ATOM   3699 C  C   . ASN B 2 156 ? -18.196 -8.786  -20.474 1    57.83  ? 326 ASN B C   1 
ATOM   3700 O  O   . ASN B 2 156 ? -18.916 -8.396  -19.562 1    67.14  ? 326 ASN B O   1 
ATOM   3701 C  CB  . ASN B 2 156 ? -19.934 -9.445  -22.235 1    49.48  ? 326 ASN B CB  1 
ATOM   3702 C  CG  . ASN B 2 156 ? -19.729 -8.228  -23.092 1    52.32  ? 326 ASN B CG  1 
ATOM   3703 O  OD1 . ASN B 2 156 ? -19.17  -7.232  -22.632 1    59.99  ? 326 ASN B OD1 1 
ATOM   3704 N  ND2 . ASN B 2 156 ? -20.183 -8.26   -24.334 1    51.96  ? 326 ASN B ND2 1 
ATOM   3705 N  N   . CYS B 2 157 ? -16.975 -8.318  -20.716 1    62.3   ? 327 CYS B N   1 
ATOM   3706 C  CA  . CYS B 2 157 ? -16.231 -7.416  -19.848 1    64.37  ? 327 CYS B CA  1 
ATOM   3707 C  C   . CYS B 2 157 ? -16.869 -6.032  -19.79  1    56.4   ? 327 CYS B C   1 
ATOM   3708 O  O   . CYS B 2 157 ? -16.793 -5.368  -18.756 1    49.78  ? 327 CYS B O   1 
ATOM   3709 C  CB  . CYS B 2 157 ? -14.79  -7.305  -20.346 1    78.18  ? 327 CYS B CB  1 
ATOM   3710 S  SG  . CYS B 2 157 ? -13.891 -8.848  -20.044 1    98.22  ? 327 CYS B SG  1 
ATOM   3711 N  N   . LYS B 2 158 ? -17.438 -5.594  -20.923 1    55.17  ? 328 LYS B N   1 
ATOM   3712 C  CA  . LYS B 2 158 ? -18.106 -4.304  -21.002 1    55.62  ? 328 LYS B CA  1 
ATOM   3713 C  C   . LYS B 2 158 ? -19.32  -4.343  -20.075 1    50.46  ? 328 LYS B C   1 
ATOM   3714 O  O   . LYS B 2 158 ? -19.521 -3.423  -19.29  1    45.3   ? 328 LYS B O   1 
ATOM   3715 C  CB  . LYS B 2 158 ? -18.444 -3.95   -22.455 1    59.46  ? 328 LYS B CB  1 
ATOM   3716 C  CG  . LYS B 2 158 ? -17.404 -3.18   -23.23  1    62.13  ? 328 LYS B CG  1 
ATOM   3717 C  CD  . LYS B 2 158 ? -17.395 -3.518  -24.718 1    77.55  ? 328 LYS B CD  1 
ATOM   3718 C  CE  . LYS B 2 158 ? -18.621 -3.478  -25.618 1    89.72  ? 328 LYS B CE  1 
ATOM   3719 N  NZ  . LYS B 2 158 ? -19.235 -2.163  -25.87  1    83.7   ? 328 LYS B NZ  1 
ATOM   3720 N  N   . VAL B 2 159 ? -20.089 -5.439  -20.158 1    49.73  ? 329 VAL B N   1 
ATOM   3721 C  CA  . VAL B 2 159 ? -21.234 -5.687  -19.284 1    48.52  ? 329 VAL B CA  1 
ATOM   3722 C  C   . VAL B 2 159 ? -20.8   -5.662  -17.811 1    46.31  ? 329 VAL B C   1 
ATOM   3723 O  O   . VAL B 2 159 ? -21.395 -4.961  -17.012 1    44.45  ? 329 VAL B O   1 
ATOM   3724 C  CB  . VAL B 2 159 ? -21.956 -7.002  -19.646 1    43.93  ? 329 VAL B CB  1 
ATOM   3725 C  CG1 . VAL B 2 159 ? -23.016 -7.388  -18.627 1    45.42  ? 329 VAL B CG1 1 
ATOM   3726 C  CG2 . VAL B 2 159 ? -22.574 -6.947  -21.027 1    44.1   ? 329 VAL B CG2 1 
ATOM   3727 N  N   . GLU B 2 160 ? -19.75  -6.411  -17.463 1    46.36  ? 330 GLU B N   1 
ATOM   3728 C  CA  . GLU B 2 160 ? -19.315 -6.519  -16.078 1    49.05  ? 330 GLU B CA  1 
ATOM   3729 C  C   . GLU B 2 160 ? -18.853 -5.166  -15.554 1    50.24  ? 330 GLU B C   1 
ATOM   3730 O  O   . GLU B 2 160 ? -19.299 -4.769  -14.49  1    54.77  ? 330 GLU B O   1 
ATOM   3731 C  CB  . GLU B 2 160 ? -18.204 -7.549  -15.894 1    47.18  ? 330 GLU B CB  1 
ATOM   3732 C  CG  . GLU B 2 160 ? -18.671 -8.966  -16.2   1    45.42  ? 330 GLU B CG  1 
ATOM   3733 C  CD  . GLU B 2 160 ? -17.595 -10.016 -16.05  1    49.46  ? 330 GLU B CD  1 
ATOM   3734 O  OE1 . GLU B 2 160 ? -16.625 -9.734  -15.328 1    54.97  ? 330 GLU B OE1 1 
ATOM   3735 O  OE2 . GLU B 2 160 ? -17.711 -11.098 -16.662 1    52.12  ? 330 GLU B OE2 1 
ATOM   3736 N  N   . SER B 2 161 ? -18.006 -4.454  -16.312 1    49.56  ? 331 SER B N   1 
ATOM   3737 C  CA  . SER B 2 161 ? -17.523 -3.145  -15.881 1    47.13  ? 331 SER B CA  1 
ATOM   3738 C  C   . SER B 2 161 ? -18.677 -2.147  -15.728 1    48.09  ? 331 SER B C   1 
ATOM   3739 O  O   . SER B 2 161 ? -18.703 -1.393  -14.748 1    45.02  ? 331 SER B O   1 
ATOM   3740 C  CB  . SER B 2 161 ? -16.449 -2.579  -16.796 1    41.86  ? 331 SER B CB  1 
ATOM   3741 O  OG  . SER B 2 161 ? -15.213 -3.242  -16.641 1    40.85  ? 331 SER B OG  1 
ATOM   3742 N  N   . LEU B 2 162 ? -19.595 -2.119  -16.716 1    44.28  ? 332 LEU B N   1 
ATOM   3743 C  CA  . LEU B 2 162 ? -20.675 -1.141  -16.725 1    44.86  ? 332 LEU B CA  1 
ATOM   3744 C  C   . LEU B 2 162 ? -21.571 -1.339  -15.501 1    46.13  ? 332 LEU B C   1 
ATOM   3745 O  O   . LEU B 2 162 ? -21.917 -0.377  -14.823 1    46.03  ? 332 LEU B O   1 
ATOM   3746 C  CB  . LEU B 2 162 ? -21.474 -1.206  -18.019 1    42.63  ? 332 LEU B CB  1 
ATOM   3747 C  CG  . LEU B 2 162 ? -22.588 -0.164  -18.153 1    47.29  ? 332 LEU B CG  1 
ATOM   3748 C  CD1 . LEU B 2 162 ? -22.036 1.247   -17.947 1    41.66  ? 332 LEU B CD1 1 
ATOM   3749 C  CD2 . LEU B 2 162 ? -23.289 -0.277  -19.513 1    47.97  ? 332 LEU B CD2 1 
ATOM   3750 N  N   . ALA B 2 163 ? -21.931 -2.599  -15.215 1    45.71  ? 333 ALA B N   1 
ATOM   3751 C  CA  . ALA B 2 163 ? -22.672 -2.94   -14.013 1    40.61  ? 333 ALA B CA  1 
ATOM   3752 C  C   . ALA B 2 163 ? -21.964 -2.441  -12.757 1    40.18  ? 333 ALA B C   1 
ATOM   3753 O  O   . ALA B 2 163 ? -22.636 -1.976  -11.853 1    39.07  ? 333 ALA B O   1 
ATOM   3754 C  CB  . ALA B 2 163 ? -22.89  -4.427  -13.936 1    36.89  ? 333 ALA B CB  1 
ATOM   3755 N  N   . MET B 2 164 ? -20.641 -2.631  -12.656 1    40.76  ? 334 MET B N   1 
ATOM   3756 C  CA  . MET B 2 164 ? -19.876 -2.177  -11.495 1    43.4   ? 334 MET B CA  1 
ATOM   3757 C  C   . MET B 2 164 ? -20.043 -0.657  -11.352 1    45.78  ? 334 MET B C   1 
ATOM   3758 O  O   . MET B 2 164 ? -20.277 -0.14   -10.25  1    44.61  ? 334 MET B O   1 
ATOM   3759 C  CB  . MET B 2 164 ? -18.378 -2.498  -11.616 1    44.71  ? 334 MET B CB  1 
ATOM   3760 C  CG  . MET B 2 164 ? -17.94  -3.926  -11.33  1    50.95  ? 334 MET B CG  1 
ATOM   3761 S  SD  . MET B 2 164 ? -18.26  -4.383  -9.611  1    64.71  ? 334 MET B SD  1 
ATOM   3762 C  CE  . MET B 2 164 ? -17.729 -6.1    -9.663  1    62.48  ? 334 MET B CE  1 
ATOM   3763 N  N   . PHE B 2 165 ? -19.918 0.041   -12.489 1    43.56  ? 335 PHE B N   1 
ATOM   3764 C  CA  . PHE B 2 165 ? -20.008 1.487   -12.562 1    46.57  ? 335 PHE B CA  1 
ATOM   3765 C  C   . PHE B 2 165 ? -21.341 1.98    -11.997 1    47.04  ? 335 PHE B C   1 
ATOM   3766 O  O   . PHE B 2 165 ? -21.402 2.882   -11.161 1    47.07  ? 335 PHE B O   1 
ATOM   3767 C  CB  . PHE B 2 165 ? -19.822 1.859   -14.035 1    45.5   ? 335 PHE B CB  1 
ATOM   3768 C  CG  . PHE B 2 165 ? -20.099 3.311   -14.365 1    46.26  ? 335 PHE B CG  1 
ATOM   3769 C  CD1 . PHE B 2 165 ? -19.319 4.336   -13.838 1    44.57  ? 335 PHE B CD1 1 
ATOM   3770 C  CD2 . PHE B 2 165 ? -21.108 3.64    -15.243 1    50.31  ? 335 PHE B CD2 1 
ATOM   3771 C  CE1 . PHE B 2 165 ? -19.551 5.655   -14.185 1    46.35  ? 335 PHE B CE1 1 
ATOM   3772 C  CE2 . PHE B 2 165 ? -21.341 4.963   -15.612 1    52.62  ? 335 PHE B CE2 1 
ATOM   3773 C  CZ  . PHE B 2 165 ? -20.57  5.969   -15.07  1    52.67  ? 335 PHE B CZ  1 
ATOM   3774 N  N   . LEU B 2 166 ? -22.421 1.351   -12.452 1    47.82  ? 336 LEU B N   1 
ATOM   3775 C  CA  . LEU B 2 166 ? -23.767 1.787   -12.136 1    44.71  ? 336 LEU B CA  1 
ATOM   3776 C  C   . LEU B 2 166 ? -24.031 1.552   -10.656 1    49.13  ? 336 LEU B C   1 
ATOM   3777 O  O   . LEU B 2 166 ? -24.621 2.406   -9.985  1    48.04  ? 336 LEU B O   1 
ATOM   3778 C  CB  . LEU B 2 166 ? -24.735 1.027   -13.036 1    41.88  ? 336 LEU B CB  1 
ATOM   3779 C  CG  . LEU B 2 166 ? -24.69  1.426   -14.518 1    39.97  ? 336 LEU B CG  1 
ATOM   3780 C  CD1 . LEU B 2 166 ? -25.53  0.468   -15.366 1    38.66  ? 336 LEU B CD1 1 
ATOM   3781 C  CD2 . LEU B 2 166 ? -25.047 2.903   -14.761 1    35.74  ? 336 LEU B CD2 1 
ATOM   3782 N  N   . GLY B 2 167 ? -23.561 0.399   -10.165 1    45     ? 337 GLY B N   1 
ATOM   3783 C  CA  . GLY B 2 167 ? -23.566 0.095   -8.747  1    42.29  ? 337 GLY B CA  1 
ATOM   3784 C  C   . GLY B 2 167 ? -22.85  1.178   -7.948  1    44.3   ? 337 GLY B C   1 
ATOM   3785 O  O   . GLY B 2 167 ? -23.334 1.581   -6.895  1    45.95  ? 337 GLY B O   1 
ATOM   3786 N  N   . GLU B 2 168 ? -21.684 1.628   -8.435  1    47.37  ? 338 GLU B N   1 
ATOM   3787 C  CA  . GLU B 2 168 ? -20.92  2.65    -7.73   1    44.82  ? 338 GLU B CA  1 
ATOM   3788 C  C   . GLU B 2 168 ? -21.706 3.961   -7.714  1    48.47  ? 338 GLU B C   1 
ATOM   3789 O  O   . GLU B 2 168 ? -21.813 4.594   -6.659  1    48.12  ? 338 GLU B O   1 
ATOM   3790 C  CB  . GLU B 2 168 ? -19.513 2.846   -8.291  1    44.26  ? 338 GLU B CB  1 
ATOM   3791 C  CG  . GLU B 2 168 ? -18.461 2.155   -7.442  1    44.94  ? 338 GLU B CG  1 
ATOM   3792 C  CD  . GLU B 2 168 ? -17.02  2.242   -7.862  1    46.94  ? 338 GLU B CD  1 
ATOM   3793 O  OE1 . GLU B 2 168 ? -16.434 3.352   -7.822  1    48.25  ? 338 GLU B OE1 1 
ATOM   3794 O  OE2 . GLU B 2 168 ? -16.48  1.167   -8.195  1    47.62  ? 338 GLU B OE2 1 
ATOM   3795 N  N   . LEU B 2 169 ? -22.294 4.343   -8.866  1    41.49  ? 339 LEU B N   1 
ATOM   3796 C  CA  . LEU B 2 169 ? -23.063 5.576   -8.907  1    41.95  ? 339 LEU B CA  1 
ATOM   3797 C  C   . LEU B 2 169 ? -24.103 5.605   -7.784  1    39.47  ? 339 LEU B C   1 
ATOM   3798 O  O   . LEU B 2 169 ? -24.339 6.664   -7.225  1    42.18  ? 339 LEU B O   1 
ATOM   3799 C  CB  . LEU B 2 169 ? -23.694 5.817   -10.272 1    38.88  ? 339 LEU B CB  1 
ATOM   3800 C  CG  . LEU B 2 169 ? -22.731 6.133   -11.419 1    43.07  ? 339 LEU B CG  1 
ATOM   3801 C  CD1 . LEU B 2 169 ? -23.525 6.406   -12.687 1    41.31  ? 339 LEU B CD1 1 
ATOM   3802 C  CD2 . LEU B 2 169 ? -21.799 7.301   -11.116 1    42.06  ? 339 LEU B CD2 1 
ATOM   3803 N  N   . SER B 2 170 ? -24.716 4.457   -7.467  1    37.71  ? 340 SER B N   1 
ATOM   3804 C  CA  . SER B 2 170 ? -25.771 4.357   -6.464  1    42.4   ? 340 SER B CA  1 
ATOM   3805 C  C   . SER B 2 170 ? -25.265 4.697   -5.048  1    42.78  ? 340 SER B C   1 
ATOM   3806 O  O   . SER B 2 170 ? -26.027 5.22    -4.25   1    46.6   ? 340 SER B O   1 
ATOM   3807 C  CB  . SER B 2 170 ? -26.462 2.99    -6.502  1    42.6   ? 340 SER B CB  1 
ATOM   3808 O  OG  . SER B 2 170 ? -25.75  2.021   -5.732  1    43.21  ? 340 SER B OG  1 
ATOM   3809 N  N   . LEU B 2 171 ? -23.993 4.399   -4.734  1    40.96  ? 341 LEU B N   1 
ATOM   3810 C  CA  . LEU B 2 171 ? -23.415 4.759   -3.456  1    39.82  ? 341 LEU B CA  1 
ATOM   3811 C  C   . LEU B 2 171 ? -23.521 6.259   -3.165  1    42.76  ? 341 LEU B C   1 
ATOM   3812 O  O   . LEU B 2 171 ? -23.526 6.651   -1.992  1    40.21  ? 341 LEU B O   1 
ATOM   3813 C  CB  . LEU B 2 171 ? -21.949 4.336   -3.443  1    44.08  ? 341 LEU B CB  1 
ATOM   3814 C  CG  . LEU B 2 171 ? -21.657 2.834   -3.514  1    44.33  ? 341 LEU B CG  1 
ATOM   3815 C  CD1 . LEU B 2 171 ? -20.146 2.683   -3.617  1    35.87  ? 341 LEU B CD1 1 
ATOM   3816 C  CD2 . LEU B 2 171 ? -22.202 2.058   -2.304  1    41.24  ? 341 LEU B CD2 1 
ATOM   3817 N  N   . ILE B 2 172 ? -23.54  7.103   -4.215  1    43.27  ? 342 ILE B N   1 
ATOM   3818 C  CA  . ILE B 2 172 ? -23.368 8.542   -4.034  1    44.23  ? 342 ILE B CA  1 
ATOM   3819 C  C   . ILE B 2 172 ? -24.618 9.158   -3.41   1    49.88  ? 342 ILE B C   1 
ATOM   3820 O  O   . ILE B 2 172 ? -24.521 10.085  -2.592  1    51.94  ? 342 ILE B O   1 
ATOM   3821 C  CB  . ILE B 2 172 ? -22.983 9.246   -5.35   1    41.8   ? 342 ILE B CB  1 
ATOM   3822 C  CG1 . ILE B 2 172 ? -21.685 8.686   -5.943  1    41.82  ? 342 ILE B CG1 1 
ATOM   3823 C  CG2 . ILE B 2 172 ? -22.917 10.768  -5.183  1    38.6   ? 342 ILE B CG2 1 
ATOM   3824 C  CD1 . ILE B 2 172 ? -20.402 9.138   -5.265  1    42.43  ? 342 ILE B CD1 1 
ATOM   3825 N  N   . ASP B 2 173 ? -25.775 8.611   -3.811  1    50.44  ? 343 ASP B N   1 
ATOM   3826 C  CA  . ASP B 2 173 ? -27.074 9.255   -3.678  1    46.3   ? 343 ASP B CA  1 
ATOM   3827 C  C   . ASP B 2 173 ? -27.954 8.446   -2.739  1    49.34  ? 343 ASP B C   1 
ATOM   3828 O  O   . ASP B 2 173 ? -28.64  7.526   -3.19   1    54.98  ? 343 ASP B O   1 
ATOM   3829 C  CB  . ASP B 2 173 ? -27.732 9.44    -5.036  1    44.56  ? 343 ASP B CB  1 
ATOM   3830 C  CG  . ASP B 2 173 ? -26.907 10.3    -5.98   1    52.55  ? 343 ASP B CG  1 
ATOM   3831 O  OD1 . ASP B 2 173 ? -26.532 11.404  -5.541  1    54.22  ? 343 ASP B OD1 1 
ATOM   3832 O  OD2 . ASP B 2 173 ? -26.622 9.856   -7.139  1    50.95  ? 343 ASP B OD2 1 
ATOM   3833 N  N   . ALA B 2 174 ? -27.949 8.829   -1.452  1    48.15  ? 344 ALA B N   1 
ATOM   3834 C  CA  . ALA B 2 174 ? -28.73  8.189   -0.404  1    48.88  ? 344 ALA B CA  1 
ATOM   3835 C  C   . ALA B 2 174 ? -30.226 8.234   -0.72   1    50.26  ? 344 ALA B C   1 
ATOM   3836 O  O   . ALA B 2 174 ? -30.957 7.305   -0.391  1    53.03  ? 344 ALA B O   1 
ATOM   3837 C  CB  . ALA B 2 174 ? -28.446 8.868   0.915   1    57.44  ? 344 ALA B CB  1 
ATOM   3838 N  N   . ASP B 2 175 ? -30.68  9.34    -1.304  1    46.55  ? 345 ASP B N   1 
ATOM   3839 C  CA  . ASP B 2 175 ? -31.988 9.388   -1.923  1    49.6   ? 345 ASP B CA  1 
ATOM   3840 C  C   . ASP B 2 175 ? -31.785 9.261   -3.43   1    51.68  ? 345 ASP B C   1 
ATOM   3841 O  O   . ASP B 2 175 ? -31.237 10.184  -4.043  1    56.28  ? 345 ASP B O   1 
ATOM   3842 C  CB  . ASP B 2 175 ? -32.634 10.736  -1.648  1    54.56  ? 345 ASP B CB  1 
ATOM   3843 C  CG  . ASP B 2 175 ? -34.068 10.899  -2.126  1    54.5   ? 345 ASP B CG  1 
ATOM   3844 O  OD1 . ASP B 2 175 ? -34.581 9.945   -2.723  1    55.91  ? 345 ASP B OD1 1 
ATOM   3845 O  OD2 . ASP B 2 175 ? -34.659 11.975  -1.892  1    57.47  ? 345 ASP B OD2 1 
ATOM   3846 N  N   . PRO B 2 176 ? -32.275 8.179   -4.089  1    53     ? 346 PRO B N   1 
ATOM   3847 C  CA  . PRO B 2 176 ? -33.157 7.188   -3.456  1    48.7   ? 346 PRO B CA  1 
ATOM   3848 C  C   . PRO B 2 176 ? -32.578 5.876   -2.947  1    47.7   ? 346 PRO B C   1 
ATOM   3849 O  O   . PRO B 2 176 ? -33.342 5.044   -2.479  1    51.33  ? 346 PRO B O   1 
ATOM   3850 C  CB  . PRO B 2 176 ? -34.057 6.84    -4.66   1    44.76  ? 346 PRO B CB  1 
ATOM   3851 C  CG  . PRO B 2 176 ? -33.065 6.744   -5.791  1    47.48  ? 346 PRO B CG  1 
ATOM   3852 C  CD  . PRO B 2 176 ? -32.111 7.926   -5.536  1    50.27  ? 346 PRO B CD  1 
ATOM   3853 N  N   . TYR B 2 177 ? -31.264 5.669   -3.047  1    44.53  ? 347 TYR B N   1 
ATOM   3854 C  CA  . TYR B 2 177 ? -30.742 4.306   -3.048  1    43.05  ? 347 TYR B CA  1 
ATOM   3855 C  C   . TYR B 2 177 ? -30.664 3.659   -1.661  1    46.01  ? 347 TYR B C   1 
ATOM   3856 O  O   . TYR B 2 177 ? -30.39  2.463   -1.567  1    50.52  ? 347 TYR B O   1 
ATOM   3857 C  CB  . TYR B 2 177 ? -29.45  4.205   -3.867  1    40.9   ? 347 TYR B CB  1 
ATOM   3858 C  CG  . TYR B 2 177 ? -29.683 4.482   -5.348  1    44.66  ? 347 TYR B CG  1 
ATOM   3859 C  CD1 . TYR B 2 177 ? -30.376 3.573   -6.136  1    43.71  ? 347 TYR B CD1 1 
ATOM   3860 C  CD2 . TYR B 2 177 ? -29.27  5.677   -5.926  1    43.63  ? 347 TYR B CD2 1 
ATOM   3861 C  CE1 . TYR B 2 177 ? -30.645 3.837   -7.464  1    45.99  ? 347 TYR B CE1 1 
ATOM   3862 C  CE2 . TYR B 2 177 ? -29.53  5.946   -7.25   1    46.83  ? 347 TYR B CE2 1 
ATOM   3863 C  CZ  . TYR B 2 177 ? -30.199 5.018   -8.022  1    48.75  ? 347 TYR B CZ  1 
ATOM   3864 O  OH  . TYR B 2 177 ? -30.448 5.295   -9.334  1    52.05  ? 347 TYR B OH  1 
ATOM   3865 N  N   . LEU B 2 178 ? -30.887 4.419   -0.581  1    46.77  ? 348 LEU B N   1 
ATOM   3866 C  CA  . LEU B 2 178 ? -30.928 3.831   0.749   1    48.45  ? 348 LEU B CA  1 
ATOM   3867 C  C   . LEU B 2 178 ? -32.09  2.848   0.88    1    51.07  ? 348 LEU B C   1 
ATOM   3868 O  O   . LEU B 2 178 ? -32.071 2.02    1.793   1    60.6   ? 348 LEU B O   1 
ATOM   3869 C  CB  . LEU B 2 178 ? -31.006 4.866   1.867   1    51.53  ? 348 LEU B CB  1 
ATOM   3870 C  CG  . LEU B 2 178 ? -29.687 5.477   2.334   1    55.75  ? 348 LEU B CG  1 
ATOM   3871 C  CD1 . LEU B 2 178 ? -29.936 6.389   3.539   1    50.37  ? 348 LEU B CD1 1 
ATOM   3872 C  CD2 . LEU B 2 178 ? -28.651 4.393   2.645   1    57.43  ? 348 LEU B CD2 1 
ATOM   3873 N  N   . LYS B 2 179 ? -33.094 2.956   0       1    50.5   ? 349 LYS B N   1 
ATOM   3874 C  CA  . LYS B 2 179 ? -34.321 2.188   0.148   1    56.05  ? 349 LYS B CA  1 
ATOM   3875 C  C   . LYS B 2 179 ? -34.231 0.851   -0.57   1    53.57  ? 349 LYS B C   1 
ATOM   3876 O  O   . LYS B 2 179 ? -35.138 0.037   -0.436  1    58.59  ? 349 LYS B O   1 
ATOM   3877 C  CB  . LYS B 2 179 ? -35.548 2.982   -0.31   1    63.66  ? 349 LYS B CB  1 
ATOM   3878 C  CG  . LYS B 2 179 ? -35.732 3.078   -1.804  1    69.94  ? 349 LYS B CG  1 
ATOM   3879 C  CD  . LYS B 2 179 ? -36.956 3.892   -2.243  1    74.16  ? 349 LYS B CD  1 
ATOM   3880 C  CE  . LYS B 2 179 ? -36.838 5.35    -1.923  1    78.99  ? 349 LYS B CE  1 
ATOM   3881 N  NZ  . LYS B 2 179 ? -37.676 6.13    -2.842  1    86     ? 349 LYS B NZ  1 
ATOM   3882 N  N   . TYR B 2 180 ? -33.124 0.622   -1.291  1    49.3   ? 350 TYR B N   1 
ATOM   3883 C  CA  . TYR B 2 180 ? -32.89  -0.627  -1.998  1    47.07  ? 350 TYR B CA  1 
ATOM   3884 C  C   . TYR B 2 180 ? -31.773 -1.426  -1.321  1    46.81  ? 350 TYR B C   1 
ATOM   3885 O  O   . TYR B 2 180 ? -30.715 -0.89   -0.942  1    50.45  ? 350 TYR B O   1 
ATOM   3886 C  CB  . TYR B 2 180 ? -32.607 -0.368  -3.489  1    46.66  ? 350 TYR B CB  1 
ATOM   3887 C  CG  . TYR B 2 180 ? -33.683 0.417   -4.232  1    44.48  ? 350 TYR B CG  1 
ATOM   3888 C  CD1 . TYR B 2 180 ? -34.961 -0.108  -4.411  1    40.82  ? 350 TYR B CD1 1 
ATOM   3889 C  CD2 . TYR B 2 180 ? -33.421 1.703   -4.721  1    41.83  ? 350 TYR B CD2 1 
ATOM   3890 C  CE1 . TYR B 2 180 ? -35.927 0.606   -5.097  1    43.01  ? 350 TYR B CE1 1 
ATOM   3891 C  CE2 . TYR B 2 180 ? -34.395 2.443   -5.376  1    40.93  ? 350 TYR B CE2 1 
ATOM   3892 C  CZ  . TYR B 2 180 ? -35.647 1.886   -5.567  1    44.8   ? 350 TYR B CZ  1 
ATOM   3893 O  OH  . TYR B 2 180 ? -36.585 2.604   -6.247  1    49.68  ? 350 TYR B OH  1 
ATOM   3894 N  N   . LEU B 2 181 ? -32.01  -2.736  -1.223  1    45.15  ? 351 LEU B N   1 
ATOM   3895 C  CA  . LEU B 2 181 ? -31.009 -3.683  -0.748  1    46.07  ? 351 LEU B CA  1 
ATOM   3896 C  C   . LEU B 2 181 ? -29.92  -3.866  -1.803  1    42.95  ? 351 LEU B C   1 
ATOM   3897 O  O   . LEU B 2 181 ? -30.159 -3.778  -3.005  1    44.93  ? 351 LEU B O   1 
ATOM   3898 C  CB  . LEU B 2 181 ? -31.675 -5.019  -0.409  1    45.16  ? 351 LEU B CB  1 
ATOM   3899 C  CG  . LEU B 2 181 ? -32.668 -4.987  0.76    1    45.14  ? 351 LEU B CG  1 
ATOM   3900 C  CD1 . LEU B 2 181 ? -33.488 -6.261  0.814   1    40     ? 351 LEU B CD1 1 
ATOM   3901 C  CD2 . LEU B 2 181 ? -31.88  -4.792  2.053   1    42.68  ? 351 LEU B CD2 1 
ATOM   3902 N  N   . PRO B 2 182 ? -28.683 -4.137  -1.372  1    40.39  ? 352 PRO B N   1 
ATOM   3903 C  CA  . PRO B 2 182 ? -27.587 -4.384  -2.302  1    37.28  ? 352 PRO B CA  1 
ATOM   3904 C  C   . PRO B 2 182 ? -27.952 -5.354  -3.404  1    39.69  ? 352 PRO B C   1 
ATOM   3905 O  O   . PRO B 2 182 ? -27.561 -5.142  -4.553  1    41.33  ? 352 PRO B O   1 
ATOM   3906 C  CB  . PRO B 2 182 ? -26.539 -4.985  -1.363  1    35.94  ? 352 PRO B CB  1 
ATOM   3907 C  CG  . PRO B 2 182 ? -26.749 -4.203  -0.087  1    39.02  ? 352 PRO B CG  1 
ATOM   3908 C  CD  . PRO B 2 182 ? -28.261 -4.104  0.043   1    39.28  ? 352 PRO B CD  1 
ATOM   3909 N  N   . SER B 2 183 ? -28.685 -6.413  -3.047  1    37.9   ? 353 SER B N   1 
ATOM   3910 C  CA  . SER B 2 183 ? -28.974 -7.465  -4.011  1    40.38  ? 353 SER B CA  1 
ATOM   3911 C  C   . SER B 2 183 ? -29.846 -6.924  -5.151  1    45.23  ? 353 SER B C   1 
ATOM   3912 O  O   . SER B 2 183 ? -29.757 -7.42   -6.281  1    46.8   ? 353 SER B O   1 
ATOM   3913 C  CB  . SER B 2 183 ? -29.594 -8.687  -3.353  1    37.33  ? 353 SER B CB  1 
ATOM   3914 O  OG  . SER B 2 183 ? -30.887 -8.382  -2.846  1    39.49  ? 353 SER B OG  1 
ATOM   3915 N  N   . VAL B 2 184 ? -30.7   -5.931  -4.829  1    44.09  ? 354 VAL B N   1 
ATOM   3916 C  CA  . VAL B 2 184 ? -31.654 -5.389  -5.779  1    42.36  ? 354 VAL B CA  1 
ATOM   3917 C  C   . VAL B 2 184 ? -30.961 -4.356  -6.668  1    43.72  ? 354 VAL B C   1 
ATOM   3918 O  O   . VAL B 2 184 ? -31.131 -4.372  -7.89   1    40.13  ? 354 VAL B O   1 
ATOM   3919 C  CB  . VAL B 2 184 ? -32.92  -4.838  -5.085  1    46.06  ? 354 VAL B CB  1 
ATOM   3920 C  CG1 . VAL B 2 184 ? -33.718 -3.933  -6.013  1    42.93  ? 354 VAL B CG1 1 
ATOM   3921 C  CG2 . VAL B 2 184 ? -33.828 -5.949  -4.538  1    41.16  ? 354 VAL B CG2 1 
ATOM   3922 N  N   . ILE B 2 185 ? -30.175 -3.45   -6.065  1    41.18  ? 355 ILE B N   1 
ATOM   3923 C  CA  . ILE B 2 185 ? -29.412 -2.497  -6.854  1    43.35  ? 355 ILE B CA  1 
ATOM   3924 C  C   . ILE B 2 185 ? -28.515 -3.243  -7.85   1    45.41  ? 355 ILE B C   1 
ATOM   3925 O  O   . ILE B 2 185 ? -28.396 -2.85   -9.02   1    44.48  ? 355 ILE B O   1 
ATOM   3926 C  CB  . ILE B 2 185 ? -28.588 -1.549  -5.975  1    45.59  ? 355 ILE B CB  1 
ATOM   3927 C  CG1 . ILE B 2 185 ? -29.48  -0.71   -5.059  1    48.26  ? 355 ILE B CG1 1 
ATOM   3928 C  CG2 . ILE B 2 185 ? -27.683 -0.661  -6.838  1    43.79  ? 355 ILE B CG2 1 
ATOM   3929 C  CD1 . ILE B 2 185 ? -28.71  -0.002  -3.955  1    39.43  ? 355 ILE B CD1 1 
ATOM   3930 N  N   . ALA B 2 186 ? -27.9   -4.323  -7.368  1    39.99  ? 356 ALA B N   1 
ATOM   3931 C  CA  . ALA B 2 186 ? -27.062 -5.171  -8.197  1    37.86  ? 356 ALA B CA  1 
ATOM   3932 C  C   . ALA B 2 186 ? -27.869 -5.758  -9.354  1    36.44  ? 356 ALA B C   1 
ATOM   3933 O  O   . ALA B 2 186 ? -27.358 -5.847  -10.464 1    42.09  ? 356 ALA B O   1 
ATOM   3934 C  CB  . ALA B 2 186 ? -26.434 -6.258  -7.359  1    31.84  ? 356 ALA B CB  1 
ATOM   3935 N  N   . ALA B 2 187 ? -29.109 -6.17   -9.089  1    34.49  ? 357 ALA B N   1 
ATOM   3936 C  CA  . ALA B 2 187 ? -29.925 -6.788  -10.118 1    38.12  ? 357 ALA B CA  1 
ATOM   3937 C  C   . ALA B 2 187 ? -30.214 -5.748  -11.189 1    41.08  ? 357 ALA B C   1 
ATOM   3938 O  O   . ALA B 2 187 ? -29.998 -6.012  -12.376 1    45.47  ? 357 ALA B O   1 
ATOM   3939 C  CB  . ALA B 2 187 ? -31.193 -7.358  -9.531  1    39.09  ? 357 ALA B CB  1 
ATOM   3940 N  N   . ALA B 2 188 ? -30.623 -4.552  -10.744 1    39.91  ? 358 ALA B N   1 
ATOM   3941 C  CA  . ALA B 2 188 ? -30.939 -3.448  -11.633 1    41.02  ? 358 ALA B CA  1 
ATOM   3942 C  C   . ALA B 2 188 ? -29.709 -3.104  -12.475 1    43.13  ? 358 ALA B C   1 
ATOM   3943 O  O   . ALA B 2 188 ? -29.789 -3.008  -13.706 1    47.11  ? 358 ALA B O   1 
ATOM   3944 C  CB  . ALA B 2 188 ? -31.45  -2.28   -10.838 1    36.4   ? 358 ALA B CB  1 
ATOM   3945 N  N   . ALA B 2 189 ? -28.57  -2.967  -11.793 1    44.75  ? 359 ALA B N   1 
ATOM   3946 C  CA  . ALA B 2 189 ? -27.31  -2.595  -12.413 1    42.61  ? 359 ALA B CA  1 
ATOM   3947 C  C   . ALA B 2 189 ? -26.944 -3.615  -13.481 1    44.7   ? 359 ALA B C   1 
ATOM   3948 O  O   . ALA B 2 189 ? -26.555 -3.229  -14.59  1    47.17  ? 359 ALA B O   1 
ATOM   3949 C  CB  . ALA B 2 189 ? -26.234 -2.489  -11.36  1    40.06  ? 359 ALA B CB  1 
ATOM   3950 N  N   . PHE B 2 190 ? -27.107 -4.903  -13.147 1    43.26  ? 360 PHE B N   1 
ATOM   3951 C  CA  . PHE B 2 190 ? -26.739 -5.968  -14.07  1    42.65  ? 360 PHE B CA  1 
ATOM   3952 C  C   . PHE B 2 190 ? -27.632 -5.92   -15.303 1    43.61  ? 360 PHE B C   1 
ATOM   3953 O  O   . PHE B 2 190 ? -27.118 -5.97   -16.415 1    47.52  ? 360 PHE B O   1 
ATOM   3954 C  CB  . PHE B 2 190 ? -26.791 -7.345  -13.417 1    42.49  ? 360 PHE B CB  1 
ATOM   3955 C  CG  . PHE B 2 190 ? -26.374 -8.459  -14.361 1    43.47  ? 360 PHE B CG  1 
ATOM   3956 C  CD1 . PHE B 2 190 ? -25.101 -8.492  -14.895 1    43.05  ? 360 PHE B CD1 1 
ATOM   3957 C  CD2 . PHE B 2 190 ? -27.257 -9.48   -14.703 1    47.64  ? 360 PHE B CD2 1 
ATOM   3958 C  CE1 . PHE B 2 190 ? -24.714 -9.512  -15.762 1    46.84  ? 360 PHE B CE1 1 
ATOM   3959 C  CE2 . PHE B 2 190 ? -26.873 -10.506 -15.561 1    48.72  ? 360 PHE B CE2 1 
ATOM   3960 C  CZ  . PHE B 2 190 ? -25.598 -10.526 -16.088 1    47.99  ? 360 PHE B CZ  1 
ATOM   3961 N  N   . HIS B 2 191 ? -28.955 -5.786  -15.101 1    43.94  ? 361 HIS B N   1 
ATOM   3962 C  CA  . HIS B 2 191 ? -29.901 -5.775  -16.213 1    41.88  ? 361 HIS B CA  1 
ATOM   3963 C  C   . HIS B 2 191 ? -29.68  -4.546  -17.082 1    42.46  ? 361 HIS B C   1 
ATOM   3964 O  O   . HIS B 2 191 ? -29.708 -4.62   -18.31  1    39.51  ? 361 HIS B O   1 
ATOM   3965 C  CB  . HIS B 2 191 ? -31.36  -5.816  -15.77  1    40.21  ? 361 HIS B CB  1 
ATOM   3966 C  CG  . HIS B 2 191 ? -32.263 -5.4    -16.887 1    42.21  ? 361 HIS B CG  1 
ATOM   3967 N  ND1 . HIS B 2 191 ? -32.628 -6.276  -17.888 1    42.63  ? 361 HIS B ND1 1 
ATOM   3968 C  CD2 . HIS B 2 191 ? -32.824 -4.199  -17.206 1    40.81  ? 361 HIS B CD2 1 
ATOM   3969 C  CE1 . HIS B 2 191 ? -33.411 -5.654  -18.761 1    42.65  ? 361 HIS B CE1 1 
ATOM   3970 N  NE2 . HIS B 2 191 ? -33.527 -4.394  -18.376 1    45.17  ? 361 HIS B NE2 1 
ATOM   3971 N  N   . LEU B 2 192 ? -29.438 -3.408  -16.433 1    42.67  ? 362 LEU B N   1 
ATOM   3972 C  CA  . LEU B 2 192 ? -29.242 -2.193  -17.205 1    44.84  ? 362 LEU B CA  1 
ATOM   3973 C  C   . LEU B 2 192 ? -27.971 -2.355  -18.043 1    48.69  ? 362 LEU B C   1 
ATOM   3974 O  O   . LEU B 2 192 ? -28.002 -2.162  -19.253 1    52.54  ? 362 LEU B O   1 
ATOM   3975 C  CB  . LEU B 2 192 ? -29.173 -1.029  -16.235 1    45.86  ? 362 LEU B CB  1 
ATOM   3976 C  CG  . LEU B 2 192 ? -29.279 0.359   -16.855 1    48.61  ? 362 LEU B CG  1 
ATOM   3977 C  CD1 . LEU B 2 192 ? -30.477 0.372   -17.76  1    48.88  ? 362 LEU B CD1 1 
ATOM   3978 C  CD2 . LEU B 2 192 ? -29.402 1.406   -15.748 1    48.98  ? 362 LEU B CD2 1 
ATOM   3979 N  N   . ALA B 2 193 ? -26.882 -2.816  -17.426 1    44.5   ? 363 ALA B N   1 
ATOM   3980 C  CA  . ALA B 2 193 ? -25.621 -2.977  -18.141 1    48.23  ? 363 ALA B CA  1 
ATOM   3981 C  C   . ALA B 2 193 ? -25.756 -3.921  -19.338 1    48.72  ? 363 ALA B C   1 
ATOM   3982 O  O   . ALA B 2 193 ? -25.324 -3.591  -20.448 1    51.98  ? 363 ALA B O   1 
ATOM   3983 C  CB  . ALA B 2 193 ? -24.516 -3.422  -17.197 1    45.04  ? 363 ALA B CB  1 
ATOM   3984 N  N   . LEU B 2 194 ? -26.387 -5.071  -19.097 1    47.37  ? 364 LEU B N   1 
ATOM   3985 C  CA  . LEU B 2 194 ? -26.641 -6.104  -20.089 1    47.96  ? 364 LEU B CA  1 
ATOM   3986 C  C   . LEU B 2 194 ? -27.446 -5.559  -21.256 1    51.39  ? 364 LEU B C   1 
ATOM   3987 O  O   . LEU B 2 194 ? -27.109 -5.818  -22.413 1    58.38  ? 364 LEU B O   1 
ATOM   3988 C  CB  . LEU B 2 194 ? -27.449 -7.187  -19.372 1    51.26  ? 364 LEU B CB  1 
ATOM   3989 C  CG  . LEU B 2 194 ? -27.602 -8.539  -20.076 1    56.08  ? 364 LEU B CG  1 
ATOM   3990 C  CD1 . LEU B 2 194 ? -26.26  -9.115  -20.517 1    59.4   ? 364 LEU B CD1 1 
ATOM   3991 C  CD2 . LEU B 2 194 ? -28.266 -9.457  -19.051 1    56.94  ? 364 LEU B CD2 1 
ATOM   3992 N  N   . TYR B 2 195 ? -28.535 -4.844  -20.935 1    50.57  ? 365 TYR B N   1 
ATOM   3993 C  CA  . TYR B 2 195 ? -29.404 -4.267  -21.936 1    51.62  ? 365 TYR B CA  1 
ATOM   3994 C  C   . TYR B 2 195 ? -28.604 -3.281  -22.779 1    51.03  ? 365 TYR B C   1 
ATOM   3995 O  O   . TYR B 2 195 ? -28.604 -3.406  -23.993 1    45.01  ? 365 TYR B O   1 
ATOM   3996 C  CB  . TYR B 2 195 ? -30.634 -3.668  -21.26  1    50.64  ? 365 TYR B CB  1 
ATOM   3997 C  CG  . TYR B 2 195 ? -31.641 -3.14   -22.264 1    54.95  ? 365 TYR B CG  1 
ATOM   3998 C  CD1 . TYR B 2 195 ? -32.322 -4.008  -23.124 1    57.9   ? 365 TYR B CD1 1 
ATOM   3999 C  CD2 . TYR B 2 195 ? -31.908 -1.779  -22.354 1    56.18  ? 365 TYR B CD2 1 
ATOM   4000 C  CE1 . TYR B 2 195 ? -33.249 -3.542  -24.047 1    57.99  ? 365 TYR B CE1 1 
ATOM   4001 C  CE2 . TYR B 2 195 ? -32.83  -1.305  -23.275 1    60.65  ? 365 TYR B CE2 1 
ATOM   4002 C  CZ  . TYR B 2 195 ? -33.497 -2.182  -24.116 1    62.28  ? 365 TYR B CZ  1 
ATOM   4003 O  OH  . TYR B 2 195 ? -34.386 -1.658  -25.004 1    74.3   ? 365 TYR B OH  1 
ATOM   4004 N  N   . THR B 2 196 ? -27.881 -2.366  -22.109 1    52.94  ? 366 THR B N   1 
ATOM   4005 C  CA  . THR B 2 196 ? -27.154 -1.264  -22.738 1    54.12  ? 366 THR B CA  1 
ATOM   4006 C  C   . THR B 2 196 ? -26.172 -1.816  -23.759 1    55.17  ? 366 THR B C   1 
ATOM   4007 O  O   . THR B 2 196 ? -26.13  -1.306  -24.874 1    60.8   ? 366 THR B O   1 
ATOM   4008 C  CB  . THR B 2 196 ? -26.406 -0.404  -21.711 1    53.5   ? 366 THR B CB  1 
ATOM   4009 O  OG1 . THR B 2 196 ? -27.322 0.167   -20.781 1    52.97  ? 366 THR B OG1 1 
ATOM   4010 C  CG2 . THR B 2 196 ? -25.623 0.736   -22.344 1    47.98  ? 366 THR B CG2 1 
ATOM   4011 N  N   . VAL B 2 197 ? -25.427 -2.87   -23.374 1    55.99  ? 367 VAL B N   1 
ATOM   4012 C  CA  . VAL B 2 197 ? -24.298 -3.37   -24.149 1    52.8   ? 367 VAL B CA  1 
ATOM   4013 C  C   . VAL B 2 197 ? -24.724 -4.374  -25.217 1    51.29  ? 367 VAL B C   1 
ATOM   4014 O  O   . VAL B 2 197 ? -24.205 -4.322  -26.336 1    53.71  ? 367 VAL B O   1 
ATOM   4015 C  CB  . VAL B 2 197 ? -23.212 -3.959  -23.237 1    52.53  ? 367 VAL B CB  1 
ATOM   4016 C  CG1 . VAL B 2 197 ? -22.198 -4.764  -24.05  1    51.4   ? 367 VAL B CG1 1 
ATOM   4017 C  CG2 . VAL B 2 197 ? -22.534 -2.877  -22.403 1    48.14  ? 367 VAL B CG2 1 
ATOM   4018 N  N   . THR B 2 198 ? -25.655 -5.278  -24.871 1    50.55  ? 368 THR B N   1 
ATOM   4019 C  CA  . THR B 2 198 ? -26.015 -6.394  -25.745 1    52.16  ? 368 THR B CA  1 
ATOM   4020 C  C   . THR B 2 198 ? -27.482 -6.383  -26.148 1    51.87  ? 368 THR B C   1 
ATOM   4021 O  O   . THR B 2 198 ? -27.888 -7.244  -26.907 1    55.62  ? 368 THR B O   1 
ATOM   4022 C  CB  . THR B 2 198 ? -25.754 -7.756  -25.099 1    51.98  ? 368 THR B CB  1 
ATOM   4023 O  OG1 . THR B 2 198 ? -26.729 -7.943  -24.077 1    52.69  ? 368 THR B OG1 1 
ATOM   4024 C  CG2 . THR B 2 198 ? -24.349 -7.905  -24.553 1    55.22  ? 368 THR B CG2 1 
ATOM   4025 N  N   . GLY B 2 199 ? -28.307 -5.538  -25.536 1    54.42  ? 369 GLY B N   1 
ATOM   4026 C  CA  . GLY B 2 199 ? -29.727 -5.573  -25.849 1    59.62  ? 369 GLY B CA  1 
ATOM   4027 C  C   . GLY B 2 199 ? -30.503 -6.67   -25.115 1    64.67  ? 369 GLY B C   1 
ATOM   4028 O  O   . GLY B 2 199 ? -31.725 -6.753  -25.224 1    68.75  ? 369 GLY B O   1 
ATOM   4029 N  N   . GLN B 2 200 ? -29.806 -7.528  -24.365 1    64.33  ? 370 GLN B N   1 
ATOM   4030 C  CA  . GLN B 2 200 ? -30.493 -8.633  -23.717 1    65.74  ? 370 GLN B CA  1 
ATOM   4031 C  C   . GLN B 2 200 ? -31.014 -8.169  -22.364 1    61.07  ? 370 GLN B C   1 
ATOM   4032 O  O   . GLN B 2 200 ? -30.714 -7.045  -21.947 1    56.91  ? 370 GLN B O   1 
ATOM   4033 C  CB  . GLN B 2 200 ? -29.535 -9.794  -23.494 1    70.34  ? 370 GLN B CB  1 
ATOM   4034 C  CG  . GLN B 2 200 ? -28.964 -10.357 -24.784 1    75.27  ? 370 GLN B CG  1 
ATOM   4035 C  CD  . GLN B 2 200 ? -27.904 -11.363 -24.436 1    86.8   ? 370 GLN B CD  1 
ATOM   4036 O  OE1 . GLN B 2 200 ? -28.182 -12.562 -24.373 1    95.43  ? 370 GLN B OE1 1 
ATOM   4037 N  NE2 . GLN B 2 200 ? -26.73  -10.866 -24.068 1    96.11  ? 370 GLN B NE2 1 
ATOM   4038 N  N   . SER B 2 201 ? -31.735 -9.072  -21.682 1    55.19  ? 371 SER B N   1 
ATOM   4039 C  CA  . SER B 2 201 ? -32.393 -8.746  -20.431 1    53.63  ? 371 SER B CA  1 
ATOM   4040 C  C   . SER B 2 201 ? -32.014 -9.732  -19.347 1    53.68  ? 371 SER B C   1 
ATOM   4041 O  O   . SER B 2 201 ? -31.606 -10.85  -19.641 1    56.96  ? 371 SER B O   1 
ATOM   4042 C  CB  . SER B 2 201 ? -33.872 -8.773  -20.59  1    56.93  ? 371 SER B CB  1 
ATOM   4043 O  OG  . SER B 2 201 ? -34.333 -7.569  -21.173 1    59.17  ? 371 SER B OG  1 
ATOM   4044 N  N   . TRP B 2 202 ? -32.203 -9.274  -18.102 1    59.87  ? 372 TRP B N   1 
ATOM   4045 C  CA  . TRP B 2 202 ? -32.189 -10.06  -16.875 1    52.64  ? 372 TRP B CA  1 
ATOM   4046 C  C   . TRP B 2 202 ? -32.617 -11.485 -17.196 1    50.51  ? 372 TRP B C   1 
ATOM   4047 O  O   . TRP B 2 202 ? -33.736 -11.695 -17.638 1    47.86  ? 372 TRP B O   1 
ATOM   4048 C  CB  . TRP B 2 202 ? -33.16  -9.416  -15.879 1    48.55  ? 372 TRP B CB  1 
ATOM   4049 C  CG  . TRP B 2 202 ? -33.214 -10.072 -14.522 1    48.41  ? 372 TRP B CG  1 
ATOM   4050 C  CD1 . TRP B 2 202 ? -34.284 -10.749 -14.028 1    50.03  ? 372 TRP B CD1 1 
ATOM   4051 C  CD2 . TRP B 2 202 ? -32.21  -10.108 -13.491 1    45.52  ? 372 TRP B CD2 1 
ATOM   4052 N  NE1 . TRP B 2 202 ? -34.02  -11.207 -12.768 1    50.29  ? 372 TRP B NE1 1 
ATOM   4053 C  CE2 . TRP B 2 202 ? -32.765 -10.819 -12.404 1    48.01  ? 372 TRP B CE2 1 
ATOM   4054 C  CE3 . TRP B 2 202 ? -30.916 -9.599  -13.357 1    46.16  ? 372 TRP B CE3 1 
ATOM   4055 C  CZ2 . TRP B 2 202 ? -32.068 -11.046 -11.219 1    45     ? 372 TRP B CZ2 1 
ATOM   4056 C  CZ3 . TRP B 2 202 ? -30.235 -9.791  -12.169 1    41.85  ? 372 TRP B CZ3 1 
ATOM   4057 C  CH2 . TRP B 2 202 ? -30.794 -10.528 -11.134 1    42.32  ? 372 TRP B CH2 1 
ATOM   4058 N  N   . PRO B 2 203 ? -31.708 -12.478 -17.088 1    48.69  ? 373 PRO B N   1 
ATOM   4059 C  CA  . PRO B 2 203 ? -31.998 -13.846 -17.533 1    48.67  ? 373 PRO B CA  1 
ATOM   4060 C  C   . PRO B 2 203 ? -32.852 -14.687 -16.604 1    47.9   ? 373 PRO B C   1 
ATOM   4061 O  O   . PRO B 2 203 ? -32.818 -14.518 -15.372 1    48.54  ? 373 PRO B O   1 
ATOM   4062 C  CB  . PRO B 2 203 ? -30.617 -14.472 -17.694 1    46.78  ? 373 PRO B CB  1 
ATOM   4063 C  CG  . PRO B 2 203 ? -29.8   -13.749 -16.63  1    52.74  ? 373 PRO B CG  1 
ATOM   4064 C  CD  . PRO B 2 203 ? -30.321 -12.305 -16.648 1    47.73  ? 373 PRO B CD  1 
ATOM   4065 N  N   . GLU B 2 204 ? -33.551 -15.621 -17.246 1    47.95  ? 374 GLU B N   1 
ATOM   4066 C  CA  . GLU B 2 204 ? -34.403 -16.58  -16.571 1    57.45  ? 374 GLU B CA  1 
ATOM   4067 C  C   . GLU B 2 204 ? -33.664 -17.188 -15.37  1    56.29  ? 374 GLU B C   1 
ATOM   4068 O  O   . GLU B 2 204 ? -34.244 -17.368 -14.293 1    55.36  ? 374 GLU B O   1 
ATOM   4069 C  CB  . GLU B 2 204 ? -34.834 -17.624 -17.606 1    66.73  ? 374 GLU B CB  1 
ATOM   4070 C  CG  . GLU B 2 204 ? -35.075 -19.027 -17.029 1    77.24  ? 374 GLU B CG  1 
ATOM   4071 C  CD  . GLU B 2 204 ? -36.341 -19.147 -16.213 1    79.55  ? 374 GLU B CD  1 
ATOM   4072 O  OE1 . GLU B 2 204 ? -37.05  -18.11  -16.068 1    89.11  ? 374 GLU B OE1 1 
ATOM   4073 O  OE2 . GLU B 2 204 ? -36.595 -20.287 -15.765 1    74.11  ? 374 GLU B OE2 1 
ATOM   4074 N  N   . SER B 2 205 ? -32.396 -17.548 -15.593 1    49.4   ? 375 SER B N   1 
ATOM   4075 C  CA  . SER B 2 205 ? -31.65  -18.328 -14.636 1    50.1   ? 375 SER B CA  1 
ATOM   4076 C  C   . SER B 2 205 ? -31.432 -17.522 -13.337 1    52.57  ? 375 SER B C   1 
ATOM   4077 O  O   . SER B 2 205 ? -31.293 -18.112 -12.249 1    45.05  ? 375 SER B O   1 
ATOM   4078 C  CB  . SER B 2 205 ? -30.368 -18.803 -15.271 1    50.05  ? 375 SER B CB  1 
ATOM   4079 O  OG  . SER B 2 205 ? -29.444 -17.724 -15.427 1    61.04  ? 375 SER B OG  1 
ATOM   4080 N  N   . LEU B 2 206 ? -31.415 -16.176 -13.447 1    49.51  ? 376 LEU B N   1 
ATOM   4081 C  CA  . LEU B 2 206 ? -31.255 -15.312 -12.28  1    49.65  ? 376 LEU B CA  1 
ATOM   4082 C  C   . LEU B 2 206 ? -32.61  -15.068 -11.609 1    49.36  ? 376 LEU B C   1 
ATOM   4083 O  O   . LEU B 2 206 ? -32.682 -14.697 -10.441 1    43.74  ? 376 LEU B O   1 
ATOM   4084 C  CB  . LEU B 2 206 ? -30.564 -14.005 -12.666 1    44.96  ? 376 LEU B CB  1 
ATOM   4085 C  CG  . LEU B 2 206 ? -29.037 -14.116 -12.787 1    49.94  ? 376 LEU B CG  1 
ATOM   4086 C  CD1 . LEU B 2 206 ? -28.413 -12.83  -13.282 1    46.51  ? 376 LEU B CD1 1 
ATOM   4087 C  CD2 . LEU B 2 206 ? -28.395 -14.561 -11.474 1    46.13  ? 376 LEU B CD2 1 
ATOM   4088 N  N   . VAL B 2 207 ? -33.683 -15.265 -12.379 1    48.41  ? 377 VAL B N   1 
ATOM   4089 C  CA  . VAL B 2 207 ? -35.006 -15.322 -11.789 1    50.99  ? 377 VAL B CA  1 
ATOM   4090 C  C   . VAL B 2 207 ? -35.112 -16.576 -10.911 1    50.15  ? 377 VAL B C   1 
ATOM   4091 O  O   . VAL B 2 207 ? -35.64  -16.509 -9.815  1    51.41  ? 377 VAL B O   1 
ATOM   4092 C  CB  . VAL B 2 207 ? -36.076 -15.234 -12.895 1    49.68  ? 377 VAL B CB  1 
ATOM   4093 C  CG1 . VAL B 2 207 ? -37.482 -15.438 -12.351 1    49.23  ? 377 VAL B CG1 1 
ATOM   4094 C  CG2 . VAL B 2 207 ? -35.967 -13.921 -13.662 1    44.46  ? 377 VAL B CG2 1 
ATOM   4095 N  N   . GLN B 2 208 ? -34.554 -17.706 -11.357 1    48.32  ? 378 GLN B N   1 
ATOM   4096 C  CA  . GLN B 2 208 ? -34.499 -18.92  -10.557 1    47.31  ? 378 GLN B CA  1 
ATOM   4097 C  C   . GLN B 2 208 ? -33.691 -18.689 -9.274  1    46.14  ? 378 GLN B C   1 
ATOM   4098 O  O   . GLN B 2 208 ? -34.113 -19.078 -8.193  1    44.93  ? 378 GLN B O   1 
ATOM   4099 C  CB  . GLN B 2 208 ? -33.844 -20.055 -11.358 1    48.89  ? 378 GLN B CB  1 
ATOM   4100 C  CG  . GLN B 2 208 ? -34.642 -20.61  -12.536 1    48.06  ? 378 GLN B CG  1 
ATOM   4101 C  CD  . GLN B 2 208 ? -35.948 -21.233 -12.094 1    56.42  ? 378 GLN B CD  1 
ATOM   4102 O  OE1 . GLN B 2 208 ? -37.008 -21.038 -12.711 1    59.19  ? 378 GLN B OE1 1 
ATOM   4103 N  NE2 . GLN B 2 208 ? -35.89  -21.994 -11.006 1    55.84  ? 378 GLN B NE2 1 
ATOM   4104 N  N   . LYS B 2 209 ? -32.515 -18.06  -9.401  1    42.73  ? 379 LYS B N   1 
ATOM   4105 C  CA  . LYS B 2 209 ? -31.606 -17.929 -8.29   1    44.33  ? 379 LYS B CA  1 
ATOM   4106 C  C   . LYS B 2 209 ? -32.163 -16.962 -7.242  1    44.43  ? 379 LYS B C   1 
ATOM   4107 O  O   . LYS B 2 209 ? -32.074 -17.231 -6.034  1    41.26  ? 379 LYS B O   1 
ATOM   4108 C  CB  . LYS B 2 209 ? -30.246 -17.453 -8.804  1    50.72  ? 379 LYS B CB  1 
ATOM   4109 C  CG  . LYS B 2 209 ? -29.147 -17.386 -7.743  1    55.38  ? 379 LYS B CG  1 
ATOM   4110 C  CD  . LYS B 2 209 ? -27.933 -16.576 -8.192  1    63.45  ? 379 LYS B CD  1 
ATOM   4111 C  CE  . LYS B 2 209 ? -26.843 -16.503 -7.145  1    63.21  ? 379 LYS B CE  1 
ATOM   4112 N  NZ  . LYS B 2 209 ? -26.366 -17.846 -6.812  1    54.94  ? 379 LYS B NZ  1 
ATOM   4113 N  N   . THR B 2 210 ? -32.703 -15.829 -7.71   1    40.66  ? 380 THR B N   1 
ATOM   4114 C  CA  . THR B 2 210 ? -32.9   -14.668 -6.849  1    44.36  ? 380 THR B CA  1 
ATOM   4115 C  C   . THR B 2 210 ? -34.359 -14.521 -6.448  1    46.45  ? 380 THR B C   1 
ATOM   4116 O  O   . THR B 2 210 ? -34.643 -13.913 -5.411  1    54.85  ? 380 THR B O   1 
ATOM   4117 C  CB  . THR B 2 210 ? -32.423 -13.365 -7.492  1    45     ? 380 THR B CB  1 
ATOM   4118 O  OG1 . THR B 2 210 ? -33.307 -12.99  -8.549  1    44.63  ? 380 THR B OG1 1 
ATOM   4119 C  CG2 . THR B 2 210 ? -30.994 -13.472 -7.985  1    45.11  ? 380 THR B CG2 1 
ATOM   4120 N  N   . GLY B 2 211 ? -35.259 -15.053 -7.279  1    42.31  ? 381 GLY B N   1 
ATOM   4121 C  CA  . GLY B 2 211 ? -36.679 -14.766 -7.134  1    42.45  ? 381 GLY B CA  1 
ATOM   4122 C  C   . GLY B 2 211 ? -37.088 -13.37  -7.626  1    42.86  ? 381 GLY B C   1 
ATOM   4123 O  O   . GLY B 2 211 ? -38.249 -13.007 -7.486  1    49.54  ? 381 GLY B O   1 
ATOM   4124 N  N   . TYR B 2 212 ? -36.158 -12.591 -8.199  1    40.81  ? 382 TYR B N   1 
ATOM   4125 C  CA  . TYR B 2 212 ? -36.465 -11.26  -8.694  1    41.46  ? 382 TYR B CA  1 
ATOM   4126 C  C   . TYR B 2 212 ? -36.786 -11.308 -10.191 1    45.93  ? 382 TYR B C   1 
ATOM   4127 O  O   . TYR B 2 212 ? -36.197 -12.088 -10.939 1    49.91  ? 382 TYR B O   1 
ATOM   4128 C  CB  . TYR B 2 212 ? -35.303 -10.29  -8.506  1    41.4   ? 382 TYR B CB  1 
ATOM   4129 C  CG  . TYR B 2 212 ? -34.749 -10.053 -7.109  1    42.97  ? 382 TYR B CG  1 
ATOM   4130 C  CD1 . TYR B 2 212 ? -35.553 -10.172 -5.961  1    40.68  ? 382 TYR B CD1 1 
ATOM   4131 C  CD2 . TYR B 2 212 ? -33.409 -9.673  -6.954  1    38.41  ? 382 TYR B CD2 1 
ATOM   4132 C  CE1 . TYR B 2 212 ? -35.023 -9.912  -4.705  1    39.06  ? 382 TYR B CE1 1 
ATOM   4133 C  CE2 . TYR B 2 212 ? -32.883 -9.395  -5.7    1    37.09  ? 382 TYR B CE2 1 
ATOM   4134 C  CZ  . TYR B 2 212 ? -33.686 -9.528  -4.576  1    39.89  ? 382 TYR B CZ  1 
ATOM   4135 O  OH  . TYR B 2 212 ? -33.127 -9.259  -3.348  1    41.41  ? 382 TYR B OH  1 
ATOM   4136 N  N   . THR B 2 213 ? -37.767 -10.501 -10.613 1    48.04  ? 383 THR B N   1 
ATOM   4137 C  CA  . THR B 2 213 ? -38.129 -10.328 -12.014 1    51.18  ? 383 THR B CA  1 
ATOM   4138 C  C   . THR B 2 213 ? -37.999 -8.856  -12.394 1    55.53  ? 383 THR B C   1 
ATOM   4139 O  O   . THR B 2 213 ? -37.843 -7.992  -11.527 1    56.9   ? 383 THR B O   1 
ATOM   4140 C  CB  . THR B 2 213 ? -39.559 -10.797 -12.255 1    50.88  ? 383 THR B CB  1 
ATOM   4141 O  OG1 . THR B 2 213 ? -40.393 -9.817  -11.646 1    49.52  ? 383 THR B OG1 1 
ATOM   4142 C  CG2 . THR B 2 213 ? -39.835 -12.181 -11.686 1    48.35  ? 383 THR B CG2 1 
ATOM   4143 N  N   . LEU B 2 214 ? -38.082 -8.574  -13.697 1    59.59  ? 384 LEU B N   1 
ATOM   4144 C  CA  . LEU B 2 214 ? -38.129 -7.198  -14.169 1    60.99  ? 384 LEU B CA  1 
ATOM   4145 C  C   . LEU B 2 214 ? -39.232 -6.421  -13.465 1    59.16  ? 384 LEU B C   1 
ATOM   4146 O  O   . LEU B 2 214 ? -39.066 -5.239  -13.195 1    64.3   ? 384 LEU B O   1 
ATOM   4147 C  CB  . LEU B 2 214 ? -38.289 -7.143  -15.682 1    62.67  ? 384 LEU B CB  1 
ATOM   4148 C  CG  . LEU B 2 214 ? -37.021 -7.442  -16.486 1    60.76  ? 384 LEU B CG  1 
ATOM   4149 C  CD1 . LEU B 2 214 ? -37.31  -7.371  -17.969 1    61.51  ? 384 LEU B CD1 1 
ATOM   4150 C  CD2 . LEU B 2 214 ? -35.961 -6.435  -16.12  1    60.87  ? 384 LEU B CD2 1 
ATOM   4151 N  N   . GLU B 2 215 ? -40.345 -7.101  -13.166 1    65.16  ? 385 GLU B N   1 
ATOM   4152 C  CA  . GLU B 2 215 ? -41.437 -6.547  -12.369 1    63.12  ? 385 GLU B CA  1 
ATOM   4153 C  C   . GLU B 2 215 ? -40.892 -6.038  -11.032 1    55.8   ? 385 GLU B C   1 
ATOM   4154 O  O   . GLU B 2 215 ? -40.992 -4.859  -10.737 1    53.33  ? 385 GLU B O   1 
ATOM   4155 C  CB  . GLU B 2 215 ? -42.514 -7.601  -12.179 1    67.28  ? 385 GLU B CB  1 
ATOM   4156 C  CG  . GLU B 2 215 ? -43.697 -7.172  -11.322 1    84.12  ? 385 GLU B CG  1 
ATOM   4157 C  CD  . GLU B 2 215 ? -44.908 -7.445  -12.162 1    109.78 ? 385 GLU B CD  1 
ATOM   4158 O  OE1 . GLU B 2 215 ? -44.864 -7.148  -13.378 1    123.01 ? 385 GLU B OE1 1 
ATOM   4159 O  OE2 . GLU B 2 215 ? -45.905 -7.935  -11.581 1    122.07 ? 385 GLU B OE2 1 
ATOM   4160 N  N   . THR B 2 216 ? -40.283 -6.92   -10.236 1    51.73  ? 386 THR B N   1 
ATOM   4161 C  CA  . THR B 2 216 ? -39.894 -6.575  -8.88   1    53.41  ? 386 THR B CA  1 
ATOM   4162 C  C   . THR B 2 216 ? -38.75  -5.564  -8.879  1    54.03  ? 386 THR B C   1 
ATOM   4163 O  O   . THR B 2 216 ? -38.644 -4.811  -7.916  1    54.56  ? 386 THR B O   1 
ATOM   4164 C  CB  . THR B 2 216 ? -39.581 -7.811  -8.03   1    52.04  ? 386 THR B CB  1 
ATOM   4165 O  OG1 . THR B 2 216 ? -38.428 -8.396  -8.615  1    48.02  ? 386 THR B OG1 1 
ATOM   4166 C  CG2 . THR B 2 216 ? -40.731 -8.804  -7.93   1    50.99  ? 386 THR B CG2 1 
ATOM   4167 N  N   . LEU B 2 217 ? -37.912 -5.567  -9.938  1    55.18  ? 387 LEU B N   1 
ATOM   4168 C  CA  . LEU B 2 217 ? -36.75  -4.694  -10.081 1    50.3   ? 387 LEU B CA  1 
ATOM   4169 C  C   . LEU B 2 217 ? -37.132 -3.317  -10.634 1    52.87  ? 387 LEU B C   1 
ATOM   4170 O  O   . LEU B 2 217 ? -36.332 -2.394  -10.53  1    51.32  ? 387 LEU B O   1 
ATOM   4171 C  CB  . LEU B 2 217 ? -35.723 -5.338  -11.008 1    49.97  ? 387 LEU B CB  1 
ATOM   4172 C  CG  . LEU B 2 217 ? -35.101 -6.666  -10.572 1    52.69  ? 387 LEU B CG  1 
ATOM   4173 C  CD1 . LEU B 2 217 ? -34.128 -7.165  -11.639 1    47.78  ? 387 LEU B CD1 1 
ATOM   4174 C  CD2 . LEU B 2 217 ? -34.413 -6.54   -9.205  1    48.82  ? 387 LEU B CD2 1 
ATOM   4175 N  N   . LYS B 2 218 ? -38.333 -3.181  -11.216 1    52.49  ? 388 LYS B N   1 
ATOM   4176 C  CA  . LYS B 2 218 ? -38.749 -2.025  -12.007 1    55.95  ? 388 LYS B CA  1 
ATOM   4177 C  C   . LYS B 2 218 ? -38.508 -0.693  -11.289 1    56.84  ? 388 LYS B C   1 
ATOM   4178 O  O   . LYS B 2 218 ? -37.95  0.228   -11.893 1    52.61  ? 388 LYS B O   1 
ATOM   4179 C  CB  . LYS B 2 218 ? -40.207 -2.157  -12.478 1    56.15  ? 388 LYS B CB  1 
ATOM   4180 C  CG  . LYS B 2 218 ? -40.736 -0.994  -13.314 1    61.8   ? 388 LYS B CG  1 
ATOM   4181 C  CD  . LYS B 2 218 ? -42.133 -1.138  -13.912 1    64.85  ? 388 LYS B CD  1 
ATOM   4182 C  CE  . LYS B 2 218 ? -42.363 -0.099  -14.996 1    75.11  ? 388 LYS B CE  1 
ATOM   4183 N  NZ  . LYS B 2 218 ? -43.57  -0.281  -15.818 1    79.07  ? 388 LYS B NZ  1 
ATOM   4184 N  N   . PRO B 2 219 ? -38.956 -0.506  -10.02  1    59.18  ? 389 PRO B N   1 
ATOM   4185 C  CA  . PRO B 2 219 ? -38.711 0.758   -9.315  1    57.17  ? 389 PRO B CA  1 
ATOM   4186 C  C   . PRO B 2 219 ? -37.232 1.164   -9.299  1    55.68  ? 389 PRO B C   1 
ATOM   4187 O  O   . PRO B 2 219 ? -36.842 2.238   -9.753  1    52.26  ? 389 PRO B O   1 
ATOM   4188 C  CB  . PRO B 2 219 ? -39.277 0.49    -7.897  1    54.19  ? 389 PRO B CB  1 
ATOM   4189 C  CG  . PRO B 2 219 ? -40.3   -0.608  -8.087  1    51.09  ? 389 PRO B CG  1 
ATOM   4190 C  CD  . PRO B 2 219 ? -39.737 -1.461  -9.212  1    54.94  ? 389 PRO B CD  1 
ATOM   4191 N  N   . CYS B 2 220 ? -36.391 0.274   -8.783  1    53.48  ? 390 CYS B N   1 
ATOM   4192 C  CA  . CYS B 2 220 ? -34.955 0.504   -8.72   1    51.21  ? 390 CYS B CA  1 
ATOM   4193 C  C   . CYS B 2 220 ? -34.372 0.831   -10.108 1    50.49  ? 390 CYS B C   1 
ATOM   4194 O  O   . CYS B 2 220 ? -33.583 1.75    -10.271 1    49.7   ? 390 CYS B O   1 
ATOM   4195 C  CB  . CYS B 2 220 ? -34.312 -0.729  -8.114  1    46.8   ? 390 CYS B CB  1 
ATOM   4196 S  SG  . CYS B 2 220 ? -32.57  -0.475  -7.75   1    49.54  ? 390 CYS B SG  1 
ATOM   4197 N  N   . LEU B 2 221 ? -34.783 0.07    -11.121 1    47.75  ? 391 LEU B N   1 
ATOM   4198 C  CA  . LEU B 2 221 ? -34.358 0.21    -12.499 1    47.47  ? 391 LEU B CA  1 
ATOM   4199 C  C   . LEU B 2 221 ? -34.705 1.59    -13.057 1    48.3   ? 391 LEU B C   1 
ATOM   4200 O  O   . LEU B 2 221 ? -33.911 2.187   -13.765 1    54.75  ? 391 LEU B O   1 
ATOM   4201 C  CB  . LEU B 2 221 ? -35.111 -0.897  -13.229 1    51.71  ? 391 LEU B CB  1 
ATOM   4202 C  CG  . LEU B 2 221 ? -34.456 -1.56   -14.438 1    57.26  ? 391 LEU B CG  1 
ATOM   4203 C  CD1 . LEU B 2 221 ? -32.932 -1.55   -14.366 1    59.28  ? 391 LEU B CD1 1 
ATOM   4204 C  CD2 . LEU B 2 221 ? -34.967 -3.013  -14.414 1    59.35  ? 391 LEU B CD2 1 
ATOM   4205 N  N   . LEU B 2 222 ? -35.879 2.118   -12.733 1    49.12  ? 392 LEU B N   1 
ATOM   4206 C  CA  . LEU B 2 222 ? -36.264 3.437   -13.211 1    48.9   ? 392 LEU B CA  1 
ATOM   4207 C  C   . LEU B 2 222 ? -35.371 4.511   -12.597 1    49.4   ? 392 LEU B C   1 
ATOM   4208 O  O   . LEU B 2 222 ? -35.025 5.481   -13.267 1    55.39  ? 392 LEU B O   1 
ATOM   4209 C  CB  . LEU B 2 222 ? -37.741 3.681   -12.915 1    50.09  ? 392 LEU B CB  1 
ATOM   4210 C  CG  . LEU B 2 222 ? -38.706 2.863   -13.781 1    55.76  ? 392 LEU B CG  1 
ATOM   4211 C  CD1 . LEU B 2 222 ? -40.171 3.155   -13.506 1    57.43  ? 392 LEU B CD1 1 
ATOM   4212 C  CD2 . LEU B 2 222 ? -38.437 3.043   -15.253 1    54.54  ? 392 LEU B CD2 1 
ATOM   4213 N  N   . ASP B 2 223 ? -34.994 4.321   -11.327 1    48.14  ? 393 ASP B N   1 
ATOM   4214 C  CA  . ASP B 2 223 ? -34.125 5.255   -10.628 1    48.76  ? 393 ASP B CA  1 
ATOM   4215 C  C   . ASP B 2 223 ? -32.714 5.196   -11.207 1    49.87  ? 393 ASP B C   1 
ATOM   4216 O  O   . ASP B 2 223 ? -32.105 6.229   -11.49  1    51.09  ? 393 ASP B O   1 
ATOM   4217 C  CB  . ASP B 2 223 ? -34.094 5.01    -9.122  1    50.59  ? 393 ASP B CB  1 
ATOM   4218 C  CG  . ASP B 2 223 ? -35.274 5.545   -8.309  1    51.85  ? 393 ASP B CG  1 
ATOM   4219 O  OD1 . ASP B 2 223 ? -35.899 6.561   -8.763  1    49.45  ? 393 ASP B OD1 1 
ATOM   4220 O  OD2 . ASP B 2 223 ? -35.586 4.915   -7.247  1    49.45  ? 393 ASP B OD2 1 
ATOM   4221 N  N   . LEU B 2 224 ? -32.203 3.976   -11.375 1    47.37  ? 394 LEU B N   1 
ATOM   4222 C  CA  . LEU B 2 224 ? -30.841 3.75    -11.832 1    46.85  ? 394 LEU B CA  1 
ATOM   4223 C  C   . LEU B 2 224 ? -30.681 4.245   -13.272 1    52.06  ? 394 LEU B C   1 
ATOM   4224 O  O   . LEU B 2 224 ? -29.638 4.77    -13.65  1    53.78  ? 394 LEU B O   1 
ATOM   4225 C  CB  . LEU B 2 224 ? -30.522 2.259   -11.726 1    45.75  ? 394 LEU B CB  1 
ATOM   4226 C  CG  . LEU B 2 224 ? -29.032 1.913   -11.759 1    43.26  ? 394 LEU B CG  1 
ATOM   4227 C  CD1 . LEU B 2 224 ? -28.354 2.597   -10.574 1    41.32  ? 394 LEU B CD1 1 
ATOM   4228 C  CD2 . LEU B 2 224 ? -28.784 0.426   -11.73  1    38.37  ? 394 LEU B CD2 1 
ATOM   4229 N  N   . HIS B 2 225 ? -31.741 4.098   -14.064 1    47.49  ? 395 HIS B N   1 
ATOM   4230 C  CA  . HIS B 2 225 ? -31.74  4.583   -15.423 1    49.4   ? 395 HIS B CA  1 
ATOM   4231 C  C   . HIS B 2 225 ? -31.689 6.114   -15.44  1    53.57  ? 395 HIS B C   1 
ATOM   4232 O  O   . HIS B 2 225 ? -31.071 6.687   -16.328 1    56.63  ? 395 HIS B O   1 
ATOM   4233 C  CB  . HIS B 2 225 ? -32.926 3.982   -16.181 1    46.81  ? 395 HIS B CB  1 
ATOM   4234 C  CG  . HIS B 2 225 ? -33.082 4.458   -17.579 1    49.01  ? 395 HIS B CG  1 
ATOM   4235 N  ND1 . HIS B 2 225 ? -32.025 4.434   -18.457 1    52.49  ? 395 HIS B ND1 1 
ATOM   4236 C  CD2 . HIS B 2 225 ? -34.134 4.916   -18.28  1    52.89  ? 395 HIS B CD2 1 
ATOM   4237 C  CE1 . HIS B 2 225 ? -32.43  4.885   -19.644 1    54.09  ? 395 HIS B CE1 1 
ATOM   4238 N  NE2 . HIS B 2 225 ? -33.707 5.167   -19.567 1    53.57  ? 395 HIS B NE2 1 
ATOM   4239 N  N   . GLN B 2 226 ? -32.354 6.788   -14.495 1    54.6   ? 396 GLN B N   1 
ATOM   4240 C  CA  . GLN B 2 226 ? -32.257 8.239   -14.425 1    59.58  ? 396 GLN B CA  1 
ATOM   4241 C  C   . GLN B 2 226 ? -30.839 8.621   -13.999 1    58.64  ? 396 GLN B C   1 
ATOM   4242 O  O   . GLN B 2 226 ? -30.203 9.502   -14.58  1    59.86  ? 396 GLN B O   1 
ATOM   4243 C  CB  . GLN B 2 226 ? -33.286 8.898   -13.5   1    66.67  ? 396 GLN B CB  1 
ATOM   4244 C  CG  . GLN B 2 226 ? -34.728 8.91    -14.003 1    81.74  ? 396 GLN B CG  1 
ATOM   4245 C  CD  . GLN B 2 226 ? -34.941 9.666   -15.304 1    100.03 ? 396 GLN B CD  1 
ATOM   4246 O  OE1 . GLN B 2 226 ? -35.347 9.1     -16.331 1    88.21  ? 396 GLN B OE1 1 
ATOM   4247 N  NE2 . GLN B 2 226 ? -34.681 10.967  -15.275 1    106.51 ? 396 GLN B NE2 1 
ATOM   4248 N  N   . THR B 2 227 ? -30.329 7.932   -12.979 1    53.23  ? 397 THR B N   1 
ATOM   4249 C  CA  . THR B 2 227 ? -29.021 8.282   -12.46  1    51.89  ? 397 THR B CA  1 
ATOM   4250 C  C   . THR B 2 227 ? -27.992 8.165   -13.581 1    49.34  ? 397 THR B C   1 
ATOM   4251 O  O   . THR B 2 227 ? -27.129 9.018   -13.693 1    55.31  ? 397 THR B O   1 
ATOM   4252 C  CB  . THR B 2 227 ? -28.683 7.421   -11.245 1    49.95  ? 397 THR B CB  1 
ATOM   4253 O  OG1 . THR B 2 227 ? -29.573 7.856   -10.217 1    47.41  ? 397 THR B OG1 1 
ATOM   4254 C  CG2 . THR B 2 227 ? -27.23  7.558   -10.825 1    44.19  ? 397 THR B CG2 1 
ATOM   4255 N  N   . TYR B 2 228 ? -28.094 7.108   -14.391 1    47.37  ? 398 TYR B N   1 
ATOM   4256 C  CA  . TYR B 2 228 ? -27.247 6.882   -15.553 1    47.54  ? 398 TYR B CA  1 
ATOM   4257 C  C   . TYR B 2 228 ? -27.384 8.038   -16.551 1    51.18  ? 398 TYR B C   1 
ATOM   4258 O  O   . TYR B 2 228 ? -26.384 8.604   -16.971 1    54.41  ? 398 TYR B O   1 
ATOM   4259 C  CB  . TYR B 2 228 ? -27.594 5.532   -16.183 1    42.38  ? 398 TYR B CB  1 
ATOM   4260 C  CG  . TYR B 2 228 ? -26.608 5.004   -17.203 1    43.47  ? 398 TYR B CG  1 
ATOM   4261 C  CD1 . TYR B 2 228 ? -25.37  5.594   -17.408 1    44.65  ? 398 TYR B CD1 1 
ATOM   4262 C  CD2 . TYR B 2 228 ? -26.905 3.871   -17.936 1    46.55  ? 398 TYR B CD2 1 
ATOM   4263 C  CE1 . TYR B 2 228 ? -24.468 5.063   -18.31  1    47.75  ? 398 TYR B CE1 1 
ATOM   4264 C  CE2 . TYR B 2 228 ? -26.017 3.336   -18.85  1    45.22  ? 398 TYR B CE2 1 
ATOM   4265 C  CZ  . TYR B 2 228 ? -24.791 3.936   -19.049 1    49.75  ? 398 TYR B CZ  1 
ATOM   4266 O  OH  . TYR B 2 228 ? -23.911 3.396   -19.969 1    52.42  ? 398 TYR B OH  1 
ATOM   4267 N  N   . LEU B 2 229 ? -28.615 8.418   -16.919 1    52.96  ? 399 LEU B N   1 
ATOM   4268 C  CA  . LEU B 2 229 ? -28.827 9.476   -17.898 1    52.77  ? 399 LEU B CA  1 
ATOM   4269 C  C   . LEU B 2 229 ? -28.23  10.794  -17.422 1    55.06  ? 399 LEU B C   1 
ATOM   4270 O  O   . LEU B 2 229 ? -27.635 11.49   -18.233 1    55.15  ? 399 LEU B O   1 
ATOM   4271 C  CB  . LEU B 2 229 ? -30.301 9.634   -18.237 1    52.63  ? 399 LEU B CB  1 
ATOM   4272 C  CG  . LEU B 2 229 ? -30.868 8.627   -19.25  1    54.81  ? 399 LEU B CG  1 
ATOM   4273 C  CD1 . LEU B 2 229 ? -32.37  8.781   -19.341 1    53.48  ? 399 LEU B CD1 1 
ATOM   4274 C  CD2 . LEU B 2 229 ? -30.294 8.795   -20.64  1    58.25  ? 399 LEU B CD2 1 
ATOM   4275 N  N   . ARG B 2 230 ? -28.35  11.099  -16.116 1    56.1   ? 400 ARG B N   1 
ATOM   4276 C  CA  . ARG B 2 230 ? -27.951 12.397  -15.588 1    59.63  ? 400 ARG B CA  1 
ATOM   4277 C  C   . ARG B 2 230 ? -26.485 12.429  -15.156 1    57.88  ? 400 ARG B C   1 
ATOM   4278 O  O   . ARG B 2 230 ? -26.002 13.475  -14.723 1    57.52  ? 400 ARG B O   1 
ATOM   4279 C  CB  . ARG B 2 230 ? -28.808 12.799  -14.384 1    66.38  ? 400 ARG B CB  1 
ATOM   4280 C  CG  . ARG B 2 230 ? -30.235 13.201  -14.731 1    80.79  ? 400 ARG B CG  1 
ATOM   4281 C  CD  . ARG B 2 230 ? -31.122 13.294  -13.501 1    95.6   ? 400 ARG B CD  1 
ATOM   4282 N  NE  . ARG B 2 230 ? -32.543 13.377  -13.855 1    114.18 ? 400 ARG B NE  1 
ATOM   4283 C  CZ  . ARG B 2 230 ? -33.594 13.18   -13.054 1    123.9  ? 400 ARG B CZ  1 
ATOM   4284 N  NH1 . ARG B 2 230 ? -33.456 12.679  -11.837 1    117.96 ? 400 ARG B NH1 1 
ATOM   4285 N  NH2 . ARG B 2 230 ? -34.804 13.48   -13.49  1    119.71 ? 400 ARG B NH2 1 
ATOM   4286 N  N   . ALA B 2 231 ? -25.773 11.305  -15.263 1    51.93  ? 401 ALA B N   1 
ATOM   4287 C  CA  . ALA B 2 231 ? -24.489 11.183  -14.583 1    52.59  ? 401 ALA B CA  1 
ATOM   4288 C  C   . ALA B 2 231 ? -23.475 12.249  -15.05  1    53.02  ? 401 ALA B C   1 
ATOM   4289 O  O   . ALA B 2 231 ? -22.68  12.751  -14.253 1    52.96  ? 401 ALA B O   1 
ATOM   4290 C  CB  . ALA B 2 231 ? -23.986 9.754   -14.707 1    46.31  ? 401 ALA B CB  1 
ATOM   4291 N  N   . PRO B 2 232 ? -23.427 12.619  -16.35  1    52.21  ? 402 PRO B N   1 
ATOM   4292 C  CA  . PRO B 2 232 ? -22.592 13.744  -16.769 1    54.13  ? 402 PRO B CA  1 
ATOM   4293 C  C   . PRO B 2 232 ? -22.881 15.08   -16.086 1    56.85  ? 402 PRO B C   1 
ATOM   4294 O  O   . PRO B 2 232 ? -21.994 15.918  -16.028 1    61.92  ? 402 PRO B O   1 
ATOM   4295 C  CB  . PRO B 2 232 ? -22.89  13.825  -18.282 1    51.54  ? 402 PRO B CB  1 
ATOM   4296 C  CG  . PRO B 2 232 ? -23.314 12.429  -18.664 1    49.25  ? 402 PRO B CG  1 
ATOM   4297 C  CD  . PRO B 2 232 ? -24.12  11.965  -17.481 1    50.06  ? 402 PRO B CD  1 
ATOM   4298 N  N   . GLN B 2 233 ? -24.106 15.281  -15.58  1    59.2   ? 403 GLN B N   1 
ATOM   4299 C  CA  . GLN B 2 233 ? -24.522 16.54   -14.965 1    60.82  ? 403 GLN B CA  1 
ATOM   4300 C  C   . GLN B 2 233 ? -24.322 16.528  -13.448 1    61.48  ? 403 GLN B C   1 
ATOM   4301 O  O   . GLN B 2 233 ? -24.36  17.591  -12.846 1    63.83  ? 403 GLN B O   1 
ATOM   4302 C  CB  . GLN B 2 233 ? -26.004 16.859  -15.178 1    62.23  ? 403 GLN B CB  1 
ATOM   4303 C  CG  . GLN B 2 233 ? -26.343 17.488  -16.523 1    80.74  ? 403 GLN B CG  1 
ATOM   4304 C  CD  . GLN B 2 233 ? -25.931 16.643  -17.707 1    90.89  ? 403 GLN B CD  1 
ATOM   4305 O  OE1 . GLN B 2 233 ? -24.993 16.975  -18.445 1    97.26  ? 403 GLN B OE1 1 
ATOM   4306 N  NE2 . GLN B 2 233 ? -26.626 15.526  -17.878 1    89.7   ? 403 GLN B NE2 1 
ATOM   4307 N  N   . HIS B 2 234 ? -24.161 15.345  -12.828 1    58.05  ? 404 HIS B N   1 
ATOM   4308 C  CA  . HIS B 2 234 ? -24.108 15.241  -11.37  1    56.44  ? 404 HIS B CA  1 
ATOM   4309 C  C   . HIS B 2 234 ? -22.992 16.152  -10.86  1    53.88  ? 404 HIS B C   1 
ATOM   4310 O  O   . HIS B 2 234 ? -21.978 16.319  -11.528 1    55.83  ? 404 HIS B O   1 
ATOM   4311 C  CB  . HIS B 2 234 ? -23.906 13.777  -10.942 1    51.51  ? 404 HIS B CB  1 
ATOM   4312 C  CG  . HIS B 2 234 ? -24.315 13.451  -9.545  1    53.05  ? 404 HIS B CG  1 
ATOM   4313 N  ND1 . HIS B 2 234 ? -23.652 13.926  -8.434  1    50.25  ? 404 HIS B ND1 1 
ATOM   4314 C  CD2 . HIS B 2 234 ? -25.326 12.668  -9.067  1    53.35  ? 404 HIS B CD2 1 
ATOM   4315 C  CE1 . HIS B 2 234 ? -24.243 13.45   -7.333  1    50.12  ? 404 HIS B CE1 1 
ATOM   4316 N  NE2 . HIS B 2 234 ? -25.266 12.69   -7.693  1    48.29  ? 404 HIS B NE2 1 
ATOM   4317 N  N   . ALA B 2 235 ? -23.2   16.762  -9.695  1    52.41  ? 405 ALA B N   1 
ATOM   4318 C  CA  . ALA B 2 235 ? -22.154 17.496  -8.986  1    54.6   ? 405 ALA B CA  1 
ATOM   4319 C  C   . ALA B 2 235 ? -20.877 16.653  -8.787  1    52.6   ? 405 ALA B C   1 
ATOM   4320 O  O   . ALA B 2 235 ? -19.775 17.175  -8.844  1    50.45  ? 405 ALA B O   1 
ATOM   4321 C  CB  . ALA B 2 235 ? -22.72  17.964  -7.652  1    47.59  ? 405 ALA B CB  1 
ATOM   4322 N  N   . GLN B 2 236 ? -21.041 15.348  -8.514  1    48.51  ? 406 GLN B N   1 
ATOM   4323 C  CA  . GLN B 2 236 ? -19.95  14.439  -8.209  1    46.7   ? 406 GLN B CA  1 
ATOM   4324 C  C   . GLN B 2 236 ? -19.596 13.626  -9.449  1    47.81  ? 406 GLN B C   1 
ATOM   4325 O  O   . GLN B 2 236 ? -20.47  13.01   -10.065 1    49.13  ? 406 GLN B O   1 
ATOM   4326 C  CB  . GLN B 2 236 ? -20.376 13.491  -7.084  1    45.32  ? 406 GLN B CB  1 
ATOM   4327 C  CG  . GLN B 2 236 ? -20.196 14.059  -5.677  1    51.59  ? 406 GLN B CG  1 
ATOM   4328 C  CD  . GLN B 2 236 ? -21.056 15.274  -5.381  1    57.37  ? 406 GLN B CD  1 
ATOM   4329 O  OE1 . GLN B 2 236 ? -22.292 15.223  -5.489  1    58.41  ? 406 GLN B OE1 1 
ATOM   4330 N  NE2 . GLN B 2 236 ? -20.404 16.378  -5.023  1    52.1   ? 406 GLN B NE2 1 
ATOM   4331 N  N   . GLN B 2 237 ? -18.299 13.606  -9.779  1    47.47  ? 407 GLN B N   1 
ATOM   4332 C  CA  . GLN B 2 237 ? -17.803 13.131  -11.066 1    48.41  ? 407 GLN B CA  1 
ATOM   4333 C  C   . GLN B 2 237 ? -16.668 12.112  -10.929 1    48.99  ? 407 GLN B C   1 
ATOM   4334 O  O   . GLN B 2 237 ? -16.213 11.566  -11.933 1    52.97  ? 407 GLN B O   1 
ATOM   4335 C  CB  . GLN B 2 237 ? -17.355 14.318  -11.914 1    46.65  ? 407 GLN B CB  1 
ATOM   4336 C  CG  . GLN B 2 237 ? -18.506 15.148  -12.487 1    49.55  ? 407 GLN B CG  1 
ATOM   4337 C  CD  . GLN B 2 237 ? -19.364 14.403  -13.486 1    49.19  ? 407 GLN B CD  1 
ATOM   4338 O  OE1 . GLN B 2 237 ? -18.859 13.615  -14.287 1    55.72  ? 407 GLN B OE1 1 
ATOM   4339 N  NE2 . GLN B 2 237 ? -20.674 14.587  -13.419 1    46.41  ? 407 GLN B NE2 1 
ATOM   4340 N  N   . SER B 2 238 ? -16.245 11.813  -9.701  1    45.78  ? 408 SER B N   1 
ATOM   4341 C  CA  . SER B 2 238 ? -15.084 10.966  -9.498  1    47.29  ? 408 SER B CA  1 
ATOM   4342 C  C   . SER B 2 238 ? -15.311 9.548   -10.036 1    45.12  ? 408 SER B C   1 
ATOM   4343 O  O   . SER B 2 238 ? -14.37  8.887   -10.447 1    44.98  ? 408 SER B O   1 
ATOM   4344 C  CB  . SER B 2 238 ? -14.693 10.937  -8.023  1    46.59  ? 408 SER B CB  1 
ATOM   4345 O  OG  . SER B 2 238 ? -14.19  12.198  -7.608  1    48.65  ? 408 SER B OG  1 
ATOM   4346 N  N   . ILE B 2 239 ? -16.542 9.056   -10.015 1    41.09  ? 409 ILE B N   1 
ATOM   4347 C  CA  . ILE B 2 239 ? -16.788 7.704   -10.496 1    43.53  ? 409 ILE B CA  1 
ATOM   4348 C  C   . ILE B 2 239 ? -16.707 7.685   -12.034 1    45.16  ? 409 ILE B C   1 
ATOM   4349 O  O   . ILE B 2 239 ? -16.1   6.788   -12.636 1    43.48  ? 409 ILE B O   1 
ATOM   4350 C  CB  . ILE B 2 239 ? -18.127 7.16    -9.93   1    41.68  ? 409 ILE B CB  1 
ATOM   4351 C  CG1 . ILE B 2 239 ? -18.05  6.93    -8.44   1    39.64  ? 409 ILE B CG1 1 
ATOM   4352 C  CG2 . ILE B 2 239 ? -18.576 5.885   -10.631 1    39.23  ? 409 ILE B CG2 1 
ATOM   4353 C  CD1 . ILE B 2 239 ? -19.392 6.643   -7.807  1    37.67  ? 409 ILE B CD1 1 
ATOM   4354 N  N   . ARG B 2 240 ? -17.285 8.697   -12.68  1    46.08  ? 410 ARG B N   1 
ATOM   4355 C  CA  . ARG B 2 240 ? -17.168 8.766   -14.16  1    46.32  ? 410 ARG B CA  1 
ATOM   4356 C  C   . ARG B 2 240 ? -15.679 8.819   -14.541 1    47.2   ? 410 ARG B C   1 
ATOM   4357 O  O   . ARG B 2 240 ? -15.272 8.054   -15.442 1    52.35  ? 410 ARG B O   1 
ATOM   4358 C  CB  . ARG B 2 240 ? -17.963 9.961   -14.692 1    48.06  ? 410 ARG B CB  1 
ATOM   4359 C  CG  . ARG B 2 240 ? -19.446 9.624   -14.729 1    52.6   ? 410 ARG B CG  1 
ATOM   4360 C  CD  . ARG B 2 240 ? -20.28  10.799  -15.188 1    55.19  ? 410 ARG B CD  1 
ATOM   4361 N  NE  . ARG B 2 240 ? -20.447 10.832  -16.644 1    54.04  ? 410 ARG B NE  1 
ATOM   4362 C  CZ  . ARG B 2 240 ? -19.771 11.634  -17.455 1    52.19  ? 410 ARG B CZ  1 
ATOM   4363 N  NH1 . ARG B 2 240 ? -19.729 11.38   -18.75  1    51.97  ? 410 ARG B NH1 1 
ATOM   4364 N  NH2 . ARG B 2 240 ? -19.143 12.688  -16.966 1    53.37  ? 410 ARG B NH2 1 
ATOM   4365 N  N   . GLU B 2 241 ? -14.902 9.674   -13.871 1    46.24  ? 411 GLU B N   1 
ATOM   4366 C  CA  . GLU B 2 241 ? -13.472 9.792   -14.16  1    52.69  ? 411 GLU B CA  1 
ATOM   4367 C  C   . GLU B 2 241 ? -12.816 8.41    -14.067 1    51.82  ? 411 GLU B C   1 
ATOM   4368 O  O   . GLU B 2 241 ? -12.149 7.96    -14.987 1    53.93  ? 411 GLU B O   1 
ATOM   4369 C  CB  . GLU B 2 241 ? -12.708 10.73   -13.21  1    57.44  ? 411 GLU B CB  1 
ATOM   4370 C  CG  . GLU B 2 241 ? -13.203 12.179  -13.117 1    63.88  ? 411 GLU B CG  1 
ATOM   4371 C  CD  . GLU B 2 241 ? -13.255 12.945  -14.435 1    76.48  ? 411 GLU B CD  1 
ATOM   4372 O  OE1 . GLU B 2 241 ? -12.444 12.644  -15.354 1    72.5   ? 411 GLU B OE1 1 
ATOM   4373 O  OE2 . GLU B 2 241 ? -14.136 13.839  -14.568 1    80.47  ? 411 GLU B OE2 1 
ATOM   4374 N  N   . LYS B 2 242 ? -13.005 7.743   -12.932 1    48.4   ? 412 LYS B N   1 
ATOM   4375 C  CA  . LYS B 2 242 ? -12.413 6.453   -12.661 1    48.6   ? 412 LYS B CA  1 
ATOM   4376 C  C   . LYS B 2 242 ? -12.757 5.468   -13.779 1    51.59  ? 412 LYS B C   1 
ATOM   4377 O  O   . LYS B 2 242 ? -11.873 4.736   -14.22  1    57.17  ? 412 LYS B O   1 
ATOM   4378 C  CB  . LYS B 2 242 ? -12.901 5.978   -11.283 1    42.78  ? 412 LYS B CB  1 
ATOM   4379 C  CG  . LYS B 2 242 ? -12.744 4.486   -10.985 1    39.99  ? 412 LYS B CG  1 
ATOM   4380 C  CD  . LYS B 2 242 ? -13.265 4.222   -9.568  1    42.9   ? 412 LYS B CD  1 
ATOM   4381 C  CE  . LYS B 2 242 ? -13.17  2.798   -9.095  1    36.67  ? 412 LYS B CE  1 
ATOM   4382 N  NZ  . LYS B 2 242 ? -13.854 2.666   -7.815  1    34.52  ? 412 LYS B NZ  1 
ATOM   4383 N  N   . TYR B 2 243 ? -14.027 5.434   -14.211 1    47.05  ? 413 TYR B N   1 
ATOM   4384 C  CA  . TYR B 2 243 ? -14.472 4.419   -15.153 1    45.98  ? 413 TYR B CA  1 
ATOM   4385 C  C   . TYR B 2 243 ? -14.185 4.827   -16.616 1    52.65  ? 413 TYR B C   1 
ATOM   4386 O  O   . TYR B 2 243 ? -14.577 4.092   -17.533 1    60.41  ? 413 TYR B O   1 
ATOM   4387 C  CB  . TYR B 2 243 ? -15.923 4.009   -14.863 1    40.89  ? 413 TYR B CB  1 
ATOM   4388 C  CG  . TYR B 2 243 ? -16.051 3.016   -13.72  1    43.78  ? 413 TYR B CG  1 
ATOM   4389 C  CD1 . TYR B 2 243 ? -16.056 3.444   -12.387 1    42.53  ? 413 TYR B CD1 1 
ATOM   4390 C  CD2 . TYR B 2 243 ? -16.151 1.65    -13.962 1    43.23  ? 413 TYR B CD2 1 
ATOM   4391 C  CE1 . TYR B 2 243 ? -16.172 2.553   -11.331 1    39.28  ? 413 TYR B CE1 1 
ATOM   4392 C  CE2 . TYR B 2 243 ? -16.244 0.746   -12.917 1    41.87  ? 413 TYR B CE2 1 
ATOM   4393 C  CZ  . TYR B 2 243 ? -16.241 1.195   -11.602 1    43.6   ? 413 TYR B CZ  1 
ATOM   4394 O  OH  . TYR B 2 243 ? -16.279 0.289   -10.578 1    41.51  ? 413 TYR B OH  1 
ATOM   4395 N  N   . LYS B 2 244 ? -13.497 5.962   -16.869 1    46.63  ? 414 LYS B N   1 
ATOM   4396 C  CA  . LYS B 2 244 ? -12.87  6.202   -18.168 1    49.78  ? 414 LYS B CA  1 
ATOM   4397 C  C   . LYS B 2 244 ? -11.613 5.34    -18.358 1    54.45  ? 414 LYS B C   1 
ATOM   4398 O  O   . LYS B 2 244 ? -11.234 5.027   -19.488 1    59.77  ? 414 LYS B O   1 
ATOM   4399 C  CB  . LYS B 2 244 ? -12.417 7.654   -18.346 1    50.37  ? 414 LYS B CB  1 
ATOM   4400 C  CG  . LYS B 2 244 ? -13.519 8.68    -18.366 1    51.86  ? 414 LYS B CG  1 
ATOM   4401 C  CD  . LYS B 2 244 ? -13.002 10.108  -18.271 1    53.98  ? 414 LYS B CD  1 
ATOM   4402 C  CE  . LYS B 2 244 ? -14.203 11.046  -18.228 1    62.5   ? 414 LYS B CE  1 
ATOM   4403 N  NZ  . LYS B 2 244 ? -13.866 12.443  -17.92  1    67.38  ? 414 LYS B NZ  1 
ATOM   4404 N  N   . ASN B 2 245 ? -10.95  4.974   -17.247 1    52.82  ? 415 ASN B N   1 
ATOM   4405 C  CA  . ASN B 2 245 ? -9.737  4.182   -17.275 1    54.9   ? 415 ASN B CA  1 
ATOM   4406 C  C   . ASN B 2 245 ? -9.958  2.859   -18.004 1    55.22  ? 415 ASN B C   1 
ATOM   4407 O  O   . ASN B 2 245 ? -11.028 2.248   -17.912 1    50.29  ? 415 ASN B O   1 
ATOM   4408 C  CB  . ASN B 2 245 ? -9.226  3.943   -15.864 1    63.29  ? 415 ASN B CB  1 
ATOM   4409 C  CG  . ASN B 2 245 ? -7.76   3.568   -15.809 1    72.21  ? 415 ASN B CG  1 
ATOM   4410 O  OD1 . ASN B 2 245 ? -7.411  2.412   -16.084 1    77.03  ? 415 ASN B OD1 1 
ATOM   4411 N  ND2 . ASN B 2 245 ? -6.903  4.521   -15.438 1    70.68  ? 415 ASN B ND2 1 
ATOM   4412 N  N   . SER B 2 246 ? -8.904  2.421   -18.706 1    56.95  ? 416 SER B N   1 
ATOM   4413 C  CA  . SER B 2 246 ? -8.929  1.188   -19.471 1    58.95  ? 416 SER B CA  1 
ATOM   4414 C  C   . SER B 2 246 ? -9.122  -0.022  -18.555 1    56.79  ? 416 SER B C   1 
ATOM   4415 O  O   . SER B 2 246 ? -9.747  -1.001  -18.943 1    62.46  ? 416 SER B O   1 
ATOM   4416 C  CB  . SER B 2 246 ? -7.727  1.075   -20.354 1    62.25  ? 416 SER B CB  1 
ATOM   4417 O  OG  . SER B 2 246 ? -6.593  0.948   -19.513 1    79.57  ? 416 SER B OG  1 
ATOM   4418 N  N   . LYS B 2 247 ? -8.661  0.076   -17.309 1    56.68  ? 417 LYS B N   1 
ATOM   4419 C  CA  . LYS B 2 247 ? -8.835  -0.982  -16.325 1    58.02  ? 417 LYS B CA  1 
ATOM   4420 C  C   . LYS B 2 247 ? -10.293 -1.45   -16.28  1    58.36  ? 417 LYS B C   1 
ATOM   4421 O  O   . LYS B 2 247 ? -10.56  -2.631  -16.083 1    54.53  ? 417 LYS B O   1 
ATOM   4422 C  CB  . LYS B 2 247 ? -8.375  -0.416  -14.974 1    58.33  ? 417 LYS B CB  1 
ATOM   4423 C  CG  . LYS B 2 247 ? -8.46   -1.323  -13.757 1    60.03  ? 417 LYS B CG  1 
ATOM   4424 C  CD  . LYS B 2 247 ? -8.096  -0.523  -12.5   1    68.75  ? 417 LYS B CD  1 
ATOM   4425 C  CE  . LYS B 2 247 ? -7.58   -1.328  -11.335 1    73.09  ? 417 LYS B CE  1 
ATOM   4426 N  NZ  . LYS B 2 247 ? -8.452  -2.451  -10.985 1    71.98  ? 417 LYS B NZ  1 
ATOM   4427 N  N   . TYR B 2 248 ? -11.225 -0.505  -16.477 1    57.84  ? 418 TYR B N   1 
ATOM   4428 C  CA  . TYR B 2 248 ? -12.653 -0.776  -16.449 1    52.36  ? 418 TYR B CA  1 
ATOM   4429 C  C   . TYR B 2 248 ? -13.259 -0.637  -17.845 1    50.76  ? 418 TYR B C   1 
ATOM   4430 O  O   . TYR B 2 248 ? -14.446 -0.404  -17.99  1    51.43  ? 418 TYR B O   1 
ATOM   4431 C  CB  . TYR B 2 248 ? -13.322 0.192   -15.47  1    58.95  ? 418 TYR B CB  1 
ATOM   4432 C  CG  . TYR B 2 248 ? -12.703 0.195   -14.077 1    59.81  ? 418 TYR B CG  1 
ATOM   4433 C  CD1 . TYR B 2 248 ? -12.875 -0.899  -13.233 1    61.19  ? 418 TYR B CD1 1 
ATOM   4434 C  CD2 . TYR B 2 248 ? -11.955 1.276   -13.626 1    51.24  ? 418 TYR B CD2 1 
ATOM   4435 C  CE1 . TYR B 2 248 ? -12.32  -0.924  -11.965 1    55.23  ? 418 TYR B CE1 1 
ATOM   4436 C  CE2 . TYR B 2 248 ? -11.376 1.253   -12.373 1    58.03  ? 418 TYR B CE2 1 
ATOM   4437 C  CZ  . TYR B 2 248 ? -11.545 0.147   -11.548 1    59.19  ? 418 TYR B CZ  1 
ATOM   4438 O  OH  . TYR B 2 248 ? -10.991 0.138   -10.291 1    67.01  ? 418 TYR B OH  1 
ATOM   4439 N  N   . HIS B 2 249 ? -12.422 -0.76   -18.868 1    46.94  ? 419 HIS B N   1 
ATOM   4440 C  CA  . HIS B 2 249 ? -12.88  -0.816  -20.24  1    53.83  ? 419 HIS B CA  1 
ATOM   4441 C  C   . HIS B 2 249 ? -13.496 0.51    -20.694 1    53.28  ? 419 HIS B C   1 
ATOM   4442 O  O   . HIS B 2 249 ? -14.182 0.55    -21.708 1    51.84  ? 419 HIS B O   1 
ATOM   4443 C  CB  . HIS B 2 249 ? -13.768 -2.051  -20.488 1    58.26  ? 419 HIS B CB  1 
ATOM   4444 C  CG  . HIS B 2 249 ? -13.154 -3.344  -20.035 1    67.93  ? 419 HIS B CG  1 
ATOM   4445 N  ND1 . HIS B 2 249 ? -13.281 -3.785  -18.726 1    68.7   ? 419 HIS B ND1 1 
ATOM   4446 C  CD2 . HIS B 2 249 ? -12.369 -4.245  -20.674 1    60.73  ? 419 HIS B CD2 1 
ATOM   4447 C  CE1 . HIS B 2 249 ? -12.615 -4.93   -18.587 1    68.25  ? 419 HIS B CE1 1 
ATOM   4448 N  NE2 . HIS B 2 249 ? -12.054 -5.217  -19.752 1    66.27  ? 419 HIS B NE2 1 
ATOM   4449 N  N   . GLY B 2 250 ? -13.231 1.603   -19.97  1    54.56  ? 420 GLY B N   1 
ATOM   4450 C  CA  . GLY B 2 250 ? -13.675 2.919   -20.41  1    55.26  ? 420 GLY B CA  1 
ATOM   4451 C  C   . GLY B 2 250 ? -15.202 3.017   -20.445 1    56.67  ? 420 GLY B C   1 
ATOM   4452 O  O   . GLY B 2 250 ? -15.736 3.819   -21.218 1    55.13  ? 420 GLY B O   1 
ATOM   4453 N  N   . VAL B 2 251 ? -15.89  2.252   -19.569 1    47.86  ? 421 VAL B N   1 
ATOM   4454 C  CA  . VAL B 2 251 ? -17.323 2.058   -19.71  1    44.98  ? 421 VAL B CA  1 
ATOM   4455 C  C   . VAL B 2 251 ? -18.11  3.339   -19.443 1    50.83  ? 421 VAL B C   1 
ATOM   4456 O  O   . VAL B 2 251 ? -19.238 3.465   -19.92  1    55.4   ? 421 VAL B O   1 
ATOM   4457 C  CB  . VAL B 2 251 ? -17.88  0.899   -18.894 1    40.85  ? 421 VAL B CB  1 
ATOM   4458 C  CG1 . VAL B 2 251 ? -17.383 -0.423  -19.46  1    40.88  ? 421 VAL B CG1 1 
ATOM   4459 C  CG2 . VAL B 2 251 ? -17.558 1.039   -17.409 1    40.83  ? 421 VAL B CG2 1 
ATOM   4460 N  N   . SER B 2 252 ? -17.523 4.305   -18.724 1    51.29  ? 422 SER B N   1 
ATOM   4461 C  CA  . SER B 2 252 ? -18.254 5.532   -18.42  1    48.82  ? 422 SER B CA  1 
ATOM   4462 C  C   . SER B 2 252 ? -18.493 6.315   -19.693 1    51.69  ? 422 SER B C   1 
ATOM   4463 O  O   . SER B 2 252 ? -19.285 7.249   -19.679 1    59.59  ? 422 SER B O   1 
ATOM   4464 C  CB  . SER B 2 252 ? -17.643 6.392   -17.325 1    45.43  ? 422 SER B CB  1 
ATOM   4465 O  OG  . SER B 2 252 ? -16.306 6.755   -17.599 1    51.02  ? 422 SER B OG  1 
ATOM   4466 N  N   . LEU B 2 253 ? -17.83  5.901   -20.78  1    54.24  ? 423 LEU B N   1 
ATOM   4467 C  CA  . LEU B 2 253 ? -17.894 6.59    -22.067 1    54.1   ? 423 LEU B CA  1 
ATOM   4468 C  C   . LEU B 2 253 ? -18.984 5.995   -22.955 1    58.7   ? 423 LEU B C   1 
ATOM   4469 O  O   . LEU B 2 253 ? -19.301 6.59    -23.986 1    60.46  ? 423 LEU B O   1 
ATOM   4470 C  CB  . LEU B 2 253 ? -16.53  6.512   -22.75  1    52.92  ? 423 LEU B CB  1 
ATOM   4471 C  CG  . LEU B 2 253 ? -15.367 7.229   -22.04  1    55.24  ? 423 LEU B CG  1 
ATOM   4472 C  CD1 . LEU B 2 253 ? -14.08  6.909   -22.795 1    54.31  ? 423 LEU B CD1 1 
ATOM   4473 C  CD2 . LEU B 2 253 ? -15.549 8.769   -21.866 1    53.61  ? 423 LEU B CD2 1 
ATOM   4474 N  N   . LEU B 2 254 ? -19.538 4.821   -22.575 1    57.72  ? 424 LEU B N   1 
ATOM   4475 C  CA  . LEU B 2 254 ? -20.686 4.248   -23.274 1    56.62  ? 424 LEU B CA  1 
ATOM   4476 C  C   . LEU B 2 254 ? -21.873 5.207   -23.154 1    60.01  ? 424 LEU B C   1 
ATOM   4477 O  O   . LEU B 2 254 ? -21.942 5.959   -22.18  1    62.55  ? 424 LEU B O   1 
ATOM   4478 C  CB  . LEU B 2 254 ? -21.002 2.875   -22.677 1    45.88  ? 424 LEU B CB  1 
ATOM   4479 C  CG  . LEU B 2 254 ? -19.992 1.771   -22.978 1    43.64  ? 424 LEU B CG  1 
ATOM   4480 C  CD1 . LEU B 2 254 ? -20.351 0.494   -22.276 1    41.12  ? 424 LEU B CD1 1 
ATOM   4481 C  CD2 . LEU B 2 254 ? -19.989 1.559   -24.516 1    43.41  ? 424 LEU B CD2 1 
ATOM   4482 N  N   . ASN B 2 255 ? -22.774 5.214   -24.155 1    62.55  ? 425 ASN B N   1 
ATOM   4483 C  CA  . ASN B 2 255 ? -23.986 6.024   -24.077 1    60.09  ? 425 ASN B CA  1 
ATOM   4484 C  C   . ASN B 2 255 ? -25.11  5.246   -23.389 1    59.74  ? 425 ASN B C   1 
ATOM   4485 O  O   . ASN B 2 255 ? -25.427 4.125   -23.788 1    61.52  ? 425 ASN B O   1 
ATOM   4486 C  CB  . ASN B 2 255 ? -24.442 6.471   -25.455 1    59.16  ? 425 ASN B CB  1 
ATOM   4487 C  CG  . ASN B 2 255 ? -23.564 7.569   -25.997 1    61.82  ? 425 ASN B CG  1 
ATOM   4488 O  OD1 . ASN B 2 255 ? -23.355 7.63    -27.214 1    66.3   ? 425 ASN B OD1 1 
ATOM   4489 N  ND2 . ASN B 2 255 ? -23.108 8.478   -25.142 1    56.73  ? 425 ASN B ND2 1 
ATOM   4490 N  N   . PRO B 2 256 ? -25.771 5.814   -22.353 1    56.26  ? 426 PRO B N   1 
ATOM   4491 C  CA  . PRO B 2 256 ? -26.945 5.158   -21.778 1    54.96  ? 426 PRO B CA  1 
ATOM   4492 C  C   . PRO B 2 256 ? -28.038 5.007   -22.84  1    60.23  ? 426 PRO B C   1 
ATOM   4493 O  O   . PRO B 2 256 ? -28.161 5.825   -23.765 1    61.28  ? 426 PRO B O   1 
ATOM   4494 C  CB  . PRO B 2 256 ? -27.372 6.119   -20.668 1    53.03  ? 426 PRO B CB  1 
ATOM   4495 C  CG  . PRO B 2 256 ? -26.792 7.458   -21.096 1    55.7   ? 426 PRO B CG  1 
ATOM   4496 C  CD  . PRO B 2 256 ? -25.463 7.119   -21.74  1    55.04  ? 426 PRO B CD  1 
ATOM   4497 N  N   . PRO B 2 257 ? -28.91  3.984   -22.71  1    59.47  ? 427 PRO B N   1 
ATOM   4498 C  CA  . PRO B 2 257 ? -30.065 3.854   -23.603 1    58.83  ? 427 PRO B CA  1 
ATOM   4499 C  C   . PRO B 2 257 ? -31.086 4.924   -23.244 1    60.48  ? 427 PRO B C   1 
ATOM   4500 O  O   . PRO B 2 257 ? -31.156 5.35    -22.092 1    61.95  ? 427 PRO B O   1 
ATOM   4501 C  CB  . PRO B 2 257 ? -30.599 2.459   -23.234 1    59.61  ? 427 PRO B CB  1 
ATOM   4502 C  CG  . PRO B 2 257 ? -30.231 2.285   -21.763 1    55.96  ? 427 PRO B CG  1 
ATOM   4503 C  CD  . PRO B 2 257 ? -28.886 2.977   -21.631 1    55.74  ? 427 PRO B CD  1 
ATOM   4504 N  N   . GLU B 2 258 ? -31.889 5.326   -24.228 1    67.04  ? 428 GLU B N   1 
ATOM   4505 C  CA  . GLU B 2 258 ? -32.844 6.398   -24.02  1    74.8   ? 428 GLU B CA  1 
ATOM   4506 C  C   . GLU B 2 258 ? -34.137 5.876   -23.402 1    69.46  ? 428 GLU B C   1 
ATOM   4507 O  O   . GLU B 2 258 ? -34.885 6.666   -22.833 1    68.61  ? 428 GLU B O   1 
ATOM   4508 C  CB  . GLU B 2 258 ? -33.066 7.165   -25.317 1    81.73  ? 428 GLU B CB  1 
ATOM   4509 C  CG  . GLU B 2 258 ? -32.094 8.332   -25.468 1    101.41 ? 428 GLU B CG  1 
ATOM   4510 C  CD  . GLU B 2 258 ? -32.074 8.978   -26.854 1    135.83 ? 428 GLU B CD  1 
ATOM   4511 O  OE1 . GLU B 2 258 ? -31.739 8.294   -27.86  1    134.05 ? 428 GLU B OE1 1 
ATOM   4512 O  OE2 . GLU B 2 258 ? -32.387 10.191  -26.934 1    159.92 ? 428 GLU B OE2 1 
ATOM   4513 N  N   . THR B 2 259 ? -34.385 4.561   -23.533 1    64.36  ? 429 THR B N   1 
ATOM   4514 C  CA  . THR B 2 259 ? -35.558 3.872   -23     1    64.6   ? 429 THR B CA  1 
ATOM   4515 C  C   . THR B 2 259 ? -35.212 2.426   -22.638 1    66.04  ? 429 THR B C   1 
ATOM   4516 O  O   . THR B 2 259 ? -34.32  1.827   -23.224 1    68.77  ? 429 THR B O   1 
ATOM   4517 C  CB  . THR B 2 259 ? -36.751 3.87    -23.966 1    65.92  ? 429 THR B CB  1 
ATOM   4518 O  OG1 . THR B 2 259 ? -36.427 3.065   -25.096 1    65.32  ? 429 THR B OG1 1 
ATOM   4519 C  CG2 . THR B 2 259 ? -37.208 5.251   -24.392 1    68.62  ? 429 THR B CG2 1 
ATOM   4520 N  N   . LEU B 2 260 ? -35.994 1.837   -21.724 1    68.4   ? 430 LEU B N   1 
ATOM   4521 C  CA  . LEU B 2 260 ? -35.775 0.485   -21.249 1    69.4   ? 430 LEU B CA  1 
ATOM   4522 C  C   . LEU B 2 260 ? -36.786 -0.502  -21.841 1    79.52  ? 430 LEU B C   1 
ATOM   4523 O  O   . LEU B 2 260 ? -36.555 -1.72   -21.776 1    73.47  ? 430 LEU B O   1 
ATOM   4524 C  CB  . LEU B 2 260 ? -35.89  0.506   -19.725 1    70.46  ? 430 LEU B CB  1 
ATOM   4525 C  CG  . LEU B 2 260 ? -34.857 1.334   -18.957 1    73.49  ? 430 LEU B CG  1 
ATOM   4526 C  CD1 . LEU B 2 260 ? -34.962 1.036   -17.461 1    74.36  ? 430 LEU B CD1 1 
ATOM   4527 C  CD2 . LEU B 2 260 ? -33.45  1.054   -19.45  1    66.46  ? 430 LEU B CD2 1 
ATOM   4528 N  N   . ASN B 2 261 ? -37.927 0.014   -22.352 1    89.78  ? 431 ASN B N   1 
ATOM   4529 C  CA  . ASN B 2 261 ? -39.081 -0.807  -22.728 1    98.54  ? 431 ASN B CA  1 
ATOM   4530 C  C   . ASN B 2 261 ? -39.372 -1.849  -21.645 1    97.94  ? 431 ASN B C   1 
ATOM   4531 O  O   . ASN B 2 261 ? -39.219 -3.048  -21.884 1    100.19 ? 431 ASN B O   1 
ATOM   4532 C  CB  . ASN B 2 261 ? -38.864 -1.56   -24.041 1    102.49 ? 431 ASN B CB  1 
ATOM   4533 C  CG  . ASN B 2 261 ? -38.311 -0.686  -25.142 1    106.29 ? 431 ASN B CG  1 
ATOM   4534 O  OD1 . ASN B 2 261 ? -37.308 -1.041  -25.77  1    112.46 ? 431 ASN B OD1 1 
ATOM   4535 N  ND2 . ASN B 2 261 ? -38.94  0.454   -25.389 1    100.03 ? 431 ASN B ND2 1 
ATOM   4536 N  N   . VAL B 2 262 ? -39.737 -1.376  -20.448 1    91.64  ? 432 VAL B N   1 
ATOM   4537 C  CA  . VAL B 2 262 ? -39.945 -2.235  -19.289 1    93.85  ? 432 VAL B CA  1 
ATOM   4538 C  C   . VAL B 2 262 ? -41.293 -1.862  -18.634 1    114.32 ? 432 VAL B C   1 
ATOM   4539 O  O   . VAL B 2 262 ? -42.353 -2.062  -19.306 1    121.77 ? 432 VAL B O   1 
ATOM   4540 C  CB  . VAL B 2 262 ? -38.767 -2.194  -18.282 1    91.96  ? 432 VAL B CB  1 
ATOM   4541 C  CG1 . VAL B 2 262 ? -38.845 -1.052  -17.27  1    84.26  ? 432 VAL B CG1 1 
ATOM   4542 C  CG2 . VAL B 2 262 ? -38.59  -3.508  -17.54  1    91.89  ? 432 VAL B CG2 1 
ATOM   4543 N  N   . GLY C 1 3   ? -16.511 0.329   31.325  1    90.94  ? -1  GLY C N   1 
ATOM   4544 C  CA  . GLY C 1 3   ? -17.288 1.388   30.653  1    103.01 ? -1  GLY C CA  1 
ATOM   4545 C  C   . GLY C 1 3   ? -16.495 2.672   30.575  1    111.87 ? -1  GLY C C   1 
ATOM   4546 O  O   . GLY C 1 3   ? -15.585 2.843   31.409  1    121.6  ? -1  GLY C O   1 
ATOM   4547 N  N   . SER C 1 4   ? -16.818 3.554   29.628  1    112.47 ? 0   SER C N   1 
ATOM   4548 C  CA  . SER C 1 4   ? -15.962 4.753   29.46   1    93.96  ? 0   SER C CA  1 
ATOM   4549 C  C   . SER C 1 4   ? -16.724 5.954   28.895  1    80.22  ? 0   SER C C   1 
ATOM   4550 O  O   . SER C 1 4   ? -17.483 5.791   27.922  1    70.44  ? 0   SER C O   1 
ATOM   4551 C  CB  . SER C 1 4   ? -14.769 4.438   28.61   1    101.45 ? 0   SER C CB  1 
ATOM   4552 O  OG  . SER C 1 4   ? -13.93  3.497   29.263  1    107.21 ? 0   SER C OG  1 
ATOM   4553 N  N   . MET C 1 5   ? -16.49  7.115   29.489  1    74.9   ? 1   MET C N   1 
ATOM   4554 C  CA  . MET C 1 5   ? -17.108 8.368   29.013  1    68.66  ? 1   MET C CA  1 
ATOM   4555 C  C   . MET C 1 5   ? -15.961 9.224   28.49   1    63.67  ? 1   MET C C   1 
ATOM   4556 O  O   . MET C 1 5   ? -16.052 10.454  28.573  1    70.16  ? 1   MET C O   1 
ATOM   4557 C  CB  . MET C 1 5   ? -17.788 9.055   30.197  1    67.85  ? 1   MET C CB  1 
ATOM   4558 C  CG  . MET C 1 5   ? -18.653 8.129   31.015  1    58.33  ? 1   MET C CG  1 
ATOM   4559 S  SD  . MET C 1 5   ? -20.158 7.833   30.075  1    63.91  ? 1   MET C SD  1 
ATOM   4560 C  CE  . MET C 1 5   ? -20.795 9.512   30.067  1    63.54  ? 1   MET C CE  1 
ATOM   4561 N  N   . GLU C 1 6   ? -14.912 8.573   28      1    59.59  ? 2   GLU C N   1 
ATOM   4562 C  CA  . GLU C 1 6   ? -13.74  9.288   27.55   1    64.16  ? 2   GLU C CA  1 
ATOM   4563 C  C   . GLU C 1 6   ? -14.104 10.159  26.351  1    60.39  ? 2   GLU C C   1 
ATOM   4564 O  O   . GLU C 1 6   ? -13.489 11.204  26.141  1    65.4   ? 2   GLU C O   1 
ATOM   4565 C  CB  . GLU C 1 6   ? -12.581 8.342   27.238  1    73.94  ? 2   GLU C CB  1 
ATOM   4566 C  CG  . GLU C 1 6   ? -11.302 9.077   26.829  1    94.77  ? 2   GLU C CG  1 
ATOM   4567 C  CD  . GLU C 1 6   ? -10.613 9.966   27.862  1    108.39 ? 2   GLU C CD  1 
ATOM   4568 O  OE1 . GLU C 1 6   ? -10.982 9.857   29.063  1    106.48 ? 2   GLU C OE1 1 
ATOM   4569 O  OE2 . GLU C 1 6   ? -9.7    10.748  27.473  1    101.32 ? 2   GLU C OE2 1 
ATOM   4570 N  N   . ASN C 1 7   ? -15.117 9.736   25.579  1    55.34  ? 3   ASN C N   1 
ATOM   4571 C  CA  . ASN C 1 7   ? -15.562 10.535  24.446  1    60.17  ? 3   ASN C CA  1 
ATOM   4572 C  C   . ASN C 1 7   ? -16.54  11.637  24.854  1    58.55  ? 3   ASN C C   1 
ATOM   4573 O  O   . ASN C 1 7   ? -16.895 12.462  24.011  1    61.66  ? 3   ASN C O   1 
ATOM   4574 C  CB  . ASN C 1 7   ? -16.184 9.709   23.328  1    63.75  ? 3   ASN C CB  1 
ATOM   4575 C  CG  . ASN C 1 7   ? -15.17  8.765   22.742  1    67.63  ? 3   ASN C CG  1 
ATOM   4576 O  OD1 . ASN C 1 7   ? -14.004 9.152   22.573  1    64.86  ? 3   ASN C OD1 1 
ATOM   4577 N  ND2 . ASN C 1 7   ? -15.587 7.527   22.494  1    64.54  ? 3   ASN C ND2 1 
ATOM   4578 N  N   . PHE C 1 8   ? -16.938 11.685  26.134  1    52.8   ? 4   PHE C N   1 
ATOM   4579 C  CA  . PHE C 1 8   ? -17.767 12.777  26.616  1    51.37  ? 4   PHE C CA  1 
ATOM   4580 C  C   . PHE C 1 8   ? -16.955 13.809  27.408  1    57.59  ? 4   PHE C C   1 
ATOM   4581 O  O   . PHE C 1 8   ? -16.25  13.465  28.364  1    61.74  ? 4   PHE C O   1 
ATOM   4582 C  CB  . PHE C 1 8   ? -18.941 12.157  27.363  1    47.56  ? 4   PHE C CB  1 
ATOM   4583 C  CG  . PHE C 1 8   ? -19.87  11.362  26.458  1    44.72  ? 4   PHE C CG  1 
ATOM   4584 C  CD1 . PHE C 1 8   ? -20.664 12.005  25.512  1    42.86  ? 4   PHE C CD1 1 
ATOM   4585 C  CD2 . PHE C 1 8   ? -19.94  9.976   26.56   1    44.72  ? 4   PHE C CD2 1 
ATOM   4586 C  CE1 . PHE C 1 8   ? -21.501 11.277  24.676  1    43.28  ? 4   PHE C CE1 1 
ATOM   4587 C  CE2 . PHE C 1 8   ? -20.777 9.246   25.724  1    46.34  ? 4   PHE C CE2 1 
ATOM   4588 C  CZ  . PHE C 1 8   ? -21.562 9.898   24.781  1    45.91  ? 4   PHE C CZ  1 
ATOM   4589 N  N   . GLN C 1 9   ? -17.06  15.078  26.963  1    60.35  ? 5   GLN C N   1 
ATOM   4590 C  CA  . GLN C 1 9   ? -16.628 16.282  27.663  1    60.03  ? 5   GLN C CA  1 
ATOM   4591 C  C   . GLN C 1 9   ? -17.835 16.962  28.326  1    61.71  ? 5   GLN C C   1 
ATOM   4592 O  O   . GLN C 1 9   ? -18.756 17.431  27.645  1    58.47  ? 5   GLN C O   1 
ATOM   4593 C  CB  . GLN C 1 9   ? -15.993 17.253  26.666  1    60.06  ? 5   GLN C CB  1 
ATOM   4594 C  CG  . GLN C 1 9   ? -15.461 18.536  27.302  1    70.02  ? 5   GLN C CG  1 
ATOM   4595 C  CD  . GLN C 1 9   ? -14.373 18.275  28.328  1    76.82  ? 5   GLN C CD  1 
ATOM   4596 O  OE1 . GLN C 1 9   ? -13.277 17.82   27.982  1    81.92  ? 5   GLN C OE1 1 
ATOM   4597 N  NE2 . GLN C 1 9   ? -14.667 18.522  29.601  1    70.19  ? 5   GLN C NE2 1 
ATOM   4598 N  N   . LYS C 1 10  ? -17.822 17.052  29.666  1    63.03  ? 6   LYS C N   1 
ATOM   4599 C  CA  . LYS C 1 10  ? -18.874 17.773  30.375  1    62.98  ? 6   LYS C CA  1 
ATOM   4600 C  C   . LYS C 1 10  ? -18.809 19.253  29.998  1    60.01  ? 6   LYS C C   1 
ATOM   4601 O  O   . LYS C 1 10  ? -17.727 19.779  29.758  1    60.28  ? 6   LYS C O   1 
ATOM   4602 C  CB  . LYS C 1 10  ? -18.766 17.458  31.871  1    71.65  ? 6   LYS C CB  1 
ATOM   4603 C  CG  . LYS C 1 10  ? -19.249 16.026  32.16   1    88.16  ? 6   LYS C CG  1 
ATOM   4604 C  CD  . LYS C 1 10  ? -19.241 15.519  33.601  1    96.93  ? 6   LYS C CD  1 
ATOM   4605 C  CE  . LYS C 1 10  ? -19.956 14.193  33.737  1    96.36  ? 6   LYS C CE  1 
ATOM   4606 N  NZ  . LYS C 1 10  ? -19.204 13.125  33.064  1    88.13  ? 6   LYS C NZ  1 
ATOM   4607 N  N   . VAL C 1 11  ? -19.97  19.908  29.906  1    57.12  ? 7   VAL C N   1 
ATOM   4608 C  CA  . VAL C 1 11  ? -20.028 21.325  29.564  1    61.6   ? 7   VAL C CA  1 
ATOM   4609 C  C   . VAL C 1 11  ? -20.569 22.127  30.76   1    61.94  ? 7   VAL C C   1 
ATOM   4610 O  O   . VAL C 1 11  ? -19.981 23.11   31.169  1    68.71  ? 7   VAL C O   1 
ATOM   4611 C  CB  . VAL C 1 11  ? -20.85  21.576  28.282  1    62.15  ? 7   VAL C CB  1 
ATOM   4612 C  CG1 . VAL C 1 11  ? -21.09  23.06   28.031  1    62.87  ? 7   VAL C CG1 1 
ATOM   4613 C  CG2 . VAL C 1 11  ? -20.195 20.93   27.072  1    61.34  ? 7   VAL C CG2 1 
ATOM   4614 N  N   . GLU C 1 12  ? -21.69  21.706  31.333  1    60.85  ? 8   GLU C N   1 
ATOM   4615 C  CA  . GLU C 1 12  ? -22.228 22.351  32.509  1    63.99  ? 8   GLU C CA  1 
ATOM   4616 C  C   . GLU C 1 12  ? -23.234 21.416  33.175  1    68.31  ? 8   GLU C C   1 
ATOM   4617 O  O   . GLU C 1 12  ? -23.771 20.506  32.525  1    59.93  ? 8   GLU C O   1 
ATOM   4618 C  CB  . GLU C 1 12  ? -22.829 23.702  32.124  1    65.58  ? 8   GLU C CB  1 
ATOM   4619 C  CG  . GLU C 1 12  ? -24.164 23.596  31.41   1    71.81  ? 8   GLU C CG  1 
ATOM   4620 C  CD  . GLU C 1 12  ? -24.621 24.859  30.71   1    80.43  ? 8   GLU C CD  1 
ATOM   4621 O  OE1 . GLU C 1 12  ? -23.816 25.28   29.837  1    80.55  ? 8   GLU C OE1 1 
ATOM   4622 O  OE2 . GLU C 1 12  ? -25.726 25.395  31.026  1    79.9   ? 8   GLU C OE2 1 
ATOM   4623 N  N   . LYS C 1 13  ? -23.46  21.646  34.478  1    70.26  ? 9   LYS C N   1 
ATOM   4624 C  CA  . LYS C 1 13  ? -24.599 21.044  35.151  1    81.07  ? 9   LYS C CA  1 
ATOM   4625 C  C   . LYS C 1 13  ? -25.857 21.724  34.611  1    80.77  ? 9   LYS C C   1 
ATOM   4626 O  O   . LYS C 1 13  ? -25.86  22.935  34.387  1    86.59  ? 9   LYS C O   1 
ATOM   4627 C  CB  . LYS C 1 13  ? -24.447 21.158  36.671  1    92.57  ? 9   LYS C CB  1 
ATOM   4628 C  CG  . LYS C 1 13  ? -25.356 20.221  37.465  1    105.71 ? 9   LYS C CG  1 
ATOM   4629 C  CD  . LYS C 1 13  ? -25.274 20.429  38.974  1    118.77 ? 9   LYS C CD  1 
ATOM   4630 C  CE  . LYS C 1 13  ? -26.55  20.103  39.692  1    128.29 ? 9   LYS C CE  1 
ATOM   4631 N  NZ  . LYS C 1 13  ? -26.495 20.574  41.077  1    139.42 ? 9   LYS C NZ  1 
ATOM   4632 N  N   . ILE C 1 14  ? -26.89  20.931  34.32   1    73.64  ? 10  ILE C N   1 
ATOM   4633 C  CA  . ILE C 1 14  ? -28.11  21.478  33.752  1    78.24  ? 10  ILE C CA  1 
ATOM   4634 C  C   . ILE C 1 14  ? -29.25  21.21   34.723  1    91.52  ? 10  ILE C C   1 
ATOM   4635 O  O   . ILE C 1 14  ? -30.381 21.632  34.492  1    112.48 ? 10  ILE C O   1 
ATOM   4636 C  CB  . ILE C 1 14  ? -28.422 20.945  32.34   1    68.71  ? 10  ILE C CB  1 
ATOM   4637 C  CG1 . ILE C 1 14  ? -28.854 19.499  32.337  1    67.6   ? 10  ILE C CG1 1 
ATOM   4638 C  CG2 . ILE C 1 14  ? -27.22  21.134  31.425  1    76.24  ? 10  ILE C CG2 1 
ATOM   4639 C  CD1 . ILE C 1 14  ? -28.962 18.942  30.92   1    65.46  ? 10  ILE C CD1 1 
ATOM   4640 N  N   . GLY C 1 15  ? -28.919 20.508  35.808  1    88.6   ? 11  GLY C N   1 
ATOM   4641 C  CA  . GLY C 1 15  ? -29.827 20.362  36.927  1    95.47  ? 11  GLY C CA  1 
ATOM   4642 C  C   . GLY C 1 15  ? -29.653 19.008  37.599  1    102.01 ? 11  GLY C C   1 
ATOM   4643 O  O   . GLY C 1 15  ? -28.62  18.35   37.443  1    99.45  ? 11  GLY C O   1 
ATOM   4644 N  N   . GLU C 1 16  ? -30.705 18.63   38.334  1    109.83 ? 12  GLU C N   1 
ATOM   4645 C  CA  . GLU C 1 16  ? -30.656 17.494  39.23   1    112.05 ? 12  GLU C CA  1 
ATOM   4646 C  C   . GLU C 1 16  ? -32.025 16.846  39.248  1    109.47 ? 12  GLU C C   1 
ATOM   4647 O  O   . GLU C 1 16  ? -33.022 17.547  39.323  1    103.1  ? 12  GLU C O   1 
ATOM   4648 C  CB  . GLU C 1 16  ? -30.207 17.934  40.624  1    97.23  ? 12  GLU C CB  1 
ATOM   4649 C  CG  . GLU C 1 16  ? -29.839 16.762  41.523  1    97.21  ? 12  GLU C CG  1 
ATOM   4650 C  CD  . GLU C 1 16  ? -28.528 17      42.268  1    116.45 ? 12  GLU C CD  1 
ATOM   4651 O  OE1 . GLU C 1 16  ? -27.999 16.068  42.924  1    124.59 ? 12  GLU C OE1 1 
ATOM   4652 O  OE2 . GLU C 1 16  ? -28.032 18.153  42.219  1    111.05 ? 12  GLU C OE2 1 
ATOM   4653 N  N   . GLY C 1 17  ? -32.023 15.513  39.155  1    138.1  ? 13  GLY C N   1 
ATOM   4654 C  CA  . GLY C 1 17  ? -33.218 14.689  39.208  1    141.25 ? 13  GLY C CA  1 
ATOM   4655 C  C   . GLY C 1 17  ? -33.131 13.716  40.381  1    148.86 ? 13  GLY C C   1 
ATOM   4656 O  O   . GLY C 1 17  ? -32.319 13.885  41.301  1    137.15 ? 13  GLY C O   1 
ATOM   4657 N  N   . THR C 1 18  ? -33.991 12.698  40.334  1    150.98 ? 14  THR C N   1 
ATOM   4658 C  CA  . THR C 1 18  ? -34.053 11.735  41.421  1    152.67 ? 14  THR C CA  1 
ATOM   4659 C  C   . THR C 1 18  ? -32.701 11.014  41.543  1    155.43 ? 14  THR C C   1 
ATOM   4660 O  O   . THR C 1 18  ? -32.208 10.773  42.648  1    152.61 ? 14  THR C O   1 
ATOM   4661 C  CB  . THR C 1 18  ? -35.284 10.836  41.247  1    130.32 ? 14  THR C CB  1 
ATOM   4662 O  OG1 . THR C 1 18  ? -35.331 9.989   42.387  1    147.21 ? 14  THR C OG1 1 
ATOM   4663 C  CG2 . THR C 1 18  ? -35.254 9.996   39.983  1    116.89 ? 14  THR C CG2 1 
ATOM   4664 N  N   . TYR C 1 19  ? -32.087 10.722  40.386  1    131.45 ? 15  TYR C N   1 
ATOM   4665 C  CA  . TYR C 1 19  ? -30.848 9.963   40.302  1    113.37 ? 15  TYR C CA  1 
ATOM   4666 C  C   . TYR C 1 19  ? -29.667 10.811  40.77   1    112.15 ? 15  TYR C C   1 
ATOM   4667 O  O   . TYR C 1 19  ? -28.759 10.315  41.451  1    98.55  ? 15  TYR C O   1 
ATOM   4668 C  CB  . TYR C 1 19  ? -30.664 9.497   38.858  1    102.38 ? 15  TYR C CB  1 
ATOM   4669 C  CG  . TYR C 1 19  ? -31.895 8.819   38.269  1    102.89 ? 15  TYR C CG  1 
ATOM   4670 C  CD1 . TYR C 1 19  ? -32.34  7.574   38.722  1    94.13  ? 15  TYR C CD1 1 
ATOM   4671 C  CD2 . TYR C 1 19  ? -32.605 9.421   37.242  1    99.64  ? 15  TYR C CD2 1 
ATOM   4672 C  CE1 . TYR C 1 19  ? -33.449 6.948   38.168  1    77.75  ? 15  TYR C CE1 1 
ATOM   4673 C  CE2 . TYR C 1 19  ? -33.71  8.801   36.676  1    91.61  ? 15  TYR C CE2 1 
ATOM   4674 C  CZ  . TYR C 1 19  ? -34.128 7.561   37.134  1    79.26  ? 15  TYR C CZ  1 
ATOM   4675 O  OH  . TYR C 1 19  ? -35.204 6.975   36.559  1    80.74  ? 15  TYR C OH  1 
ATOM   4676 N  N   . GLY C 1 20  ? -29.693 12.092  40.388  1    98.36  ? 16  GLY C N   1 
ATOM   4677 C  CA  . GLY C 1 20  ? -28.726 13.035  40.917  1    93.21  ? 16  GLY C CA  1 
ATOM   4678 C  C   . GLY C 1 20  ? -28.515 14.159  39.924  1    92.95  ? 16  GLY C C   1 
ATOM   4679 O  O   . GLY C 1 20  ? -29.481 14.761  39.476  1    111.56 ? 16  GLY C O   1 
ATOM   4680 N  N   . VAL C 1 21  ? -27.252 14.363  39.542  1    82.84  ? 17  VAL C N   1 
ATOM   4681 C  CA  . VAL C 1 21  ? -26.885 15.431  38.629  1    81.18  ? 17  VAL C CA  1 
ATOM   4682 C  C   . VAL C 1 21  ? -27.143 15.04   37.159  1    79.44  ? 17  VAL C C   1 
ATOM   4683 O  O   . VAL C 1 21  ? -26.926 13.892  36.752  1    69.14  ? 17  VAL C O   1 
ATOM   4684 C  CB  . VAL C 1 21  ? -25.427 15.841  38.913  1    81.77  ? 17  VAL C CB  1 
ATOM   4685 C  CG1 . VAL C 1 21  ? -24.487 14.638  38.996  1    83.93  ? 17  VAL C CG1 1 
ATOM   4686 C  CG2 . VAL C 1 21  ? -24.966 16.88   37.904  1    93.92  ? 17  VAL C CG2 1 
ATOM   4687 N  N   . VAL C 1 22  ? -27.647 16.013  36.376  1    65.3   ? 18  VAL C N   1 
ATOM   4688 C  CA  . VAL C 1 22  ? -27.736 15.919  34.931  1    59.33  ? 18  VAL C CA  1 
ATOM   4689 C  C   . VAL C 1 22  ? -26.773 16.94   34.325  1    59.14  ? 18  VAL C C   1 
ATOM   4690 O  O   . VAL C 1 22  ? -26.778 18.119  34.689  1    58.86  ? 18  VAL C O   1 
ATOM   4691 C  CB  . VAL C 1 22  ? -29.173 16.148  34.432  1    58.81  ? 18  VAL C CB  1 
ATOM   4692 C  CG1 . VAL C 1 22  ? -29.295 15.919  32.937  1    50.77  ? 18  VAL C CG1 1 
ATOM   4693 C  CG2 . VAL C 1 22  ? -30.162 15.252  35.159  1    58.34  ? 18  VAL C CG2 1 
ATOM   4694 N  N   . TYR C 1 23  ? -25.942 16.468  33.39   1    57.68  ? 19  TYR C N   1 
ATOM   4695 C  CA  . TYR C 1 23  ? -24.955 17.308  32.738  1    59.33  ? 19  TYR C CA  1 
ATOM   4696 C  C   . TYR C 1 23  ? -25.323 17.476  31.273  1    55.22  ? 19  TYR C C   1 
ATOM   4697 O  O   . TYR C 1 23  ? -25.843 16.563  30.648  1    55.08  ? 19  TYR C O   1 
ATOM   4698 C  CB  . TYR C 1 23  ? -23.57  16.677  32.798  1    67.9   ? 19  TYR C CB  1 
ATOM   4699 C  CG  . TYR C 1 23  ? -23.055 16.442  34.205  1    89.76  ? 19  TYR C CG  1 
ATOM   4700 C  CD1 . TYR C 1 23  ? -22.371 17.446  34.889  1    93.33  ? 19  TYR C CD1 1 
ATOM   4701 C  CD2 . TYR C 1 23  ? -23.254 15.217  34.847  1    109.86 ? 19  TYR C CD2 1 
ATOM   4702 C  CE1 . TYR C 1 23  ? -21.883 17.233  36.173  1    100.44 ? 19  TYR C CE1 1 
ATOM   4703 C  CE2 . TYR C 1 23  ? -22.768 14.992  36.13   1    124.23 ? 19  TYR C CE2 1 
ATOM   4704 C  CZ  . TYR C 1 23  ? -22.082 16.004  36.791  1    113.81 ? 19  TYR C CZ  1 
ATOM   4705 O  OH  . TYR C 1 23  ? -21.604 15.811  38.054  1    120.34 ? 19  TYR C OH  1 
ATOM   4706 N  N   . LYS C 1 24  ? -25.049 18.659  30.733  1    54.1   ? 20  LYS C N   1 
ATOM   4707 C  CA  . LYS C 1 24  ? -24.951 18.812  29.301  1    49.92  ? 20  LYS C CA  1 
ATOM   4708 C  C   . LYS C 1 24  ? -23.522 18.431  28.952  1    51.89  ? 20  LYS C C   1 
ATOM   4709 O  O   . LYS C 1 24  ? -22.588 18.833  29.64   1    53.38  ? 20  LYS C O   1 
ATOM   4710 C  CB  . LYS C 1 24  ? -25.16  20.265  28.886  1    47.64  ? 20  LYS C CB  1 
ATOM   4711 C  CG  . LYS C 1 24  ? -24.805 20.605  27.455  1    49.49  ? 20  LYS C CG  1 
ATOM   4712 C  CD  . LYS C 1 24  ? -25.179 22.06   27.185  1    51.41  ? 20  LYS C CD  1 
ATOM   4713 C  CE  . LYS C 1 24  ? -24.841 22.482  25.801  1    51.58  ? 20  LYS C CE  1 
ATOM   4714 N  NZ  . LYS C 1 24  ? -25.2   23.877  25.576  1    54.43  ? 20  LYS C NZ  1 
ATOM   4715 N  N   . ALA C 1 25  ? -23.37  17.643  27.889  1    49.07  ? 21  ALA C N   1 
ATOM   4716 C  CA  . ALA C 1 25  ? -22.071 17.13   27.5    1    51.33  ? 21  ALA C CA  1 
ATOM   4717 C  C   . ALA C 1 25  ? -21.957 17.125  25.977  1    49.89  ? 21  ALA C C   1 
ATOM   4718 O  O   . ALA C 1 25  ? -22.959 17.275  25.258  1    49.62  ? 21  ALA C O   1 
ATOM   4719 C  CB  . ALA C 1 25  ? -21.889 15.741  28.078  1    48.21  ? 21  ALA C CB  1 
ATOM   4720 N  N   . ARG C 1 26  ? -20.725 16.917  25.514  1    46.44  ? 22  ARG C N   1 
ATOM   4721 C  CA  . ARG C 1 26  ? -20.419 16.955  24.099  1    49.74  ? 22  ARG C CA  1 
ATOM   4722 C  C   . ARG C 1 26  ? -19.607 15.713  23.738  1    50.55  ? 22  ARG C C   1 
ATOM   4723 O  O   . ARG C 1 26  ? -18.608 15.413  24.398  1    51.39  ? 22  ARG C O   1 
ATOM   4724 C  CB  . ARG C 1 26  ? -19.631 18.243  23.846  1    56.24  ? 22  ARG C CB  1 
ATOM   4725 C  CG  . ARG C 1 26  ? -19.582 18.716  22.405  1    66.07  ? 22  ARG C CG  1 
ATOM   4726 C  CD  . ARG C 1 26  ? -18.742 20.002  22.295  1    68.43  ? 22  ARG C CD  1 
ATOM   4727 N  NE  . ARG C 1 26  ? -17.364 19.552  22.059  1    78.49  ? 22  ARG C NE  1 
ATOM   4728 C  CZ  . ARG C 1 26  ? -16.299 19.63   22.874  1    82.56  ? 22  ARG C CZ  1 
ATOM   4729 N  NH1 . ARG C 1 26  ? -16.404 20.2    24.061  1    81.37  ? 22  ARG C NH1 1 
ATOM   4730 N  NH2 . ARG C 1 26  ? -15.133 19.137  22.487  1    77.81  ? 22  ARG C NH2 1 
ATOM   4731 N  N   . ASN C 1 27  ? -20.068 14.984  22.705  1    45.76  ? 23  ASN C N   1 
ATOM   4732 C  CA  . ASN C 1 27  ? -19.326 13.863  22.16   1    43.14  ? 23  ASN C CA  1 
ATOM   4733 C  C   . ASN C 1 27  ? -18.102 14.42   21.442  1    45.22  ? 23  ASN C C   1 
ATOM   4734 O  O   . ASN C 1 27  ? -18.247 15.117  20.448  1    46.94  ? 23  ASN C O   1 
ATOM   4735 C  CB  . ASN C 1 27  ? -20.202 13.046  21.213  1    42.47  ? 23  ASN C CB  1 
ATOM   4736 C  CG  . ASN C 1 27  ? -19.544 11.764  20.722  1    43.99  ? 23  ASN C CG  1 
ATOM   4737 O  OD1 . ASN C 1 27  ? -18.416 11.78   20.174  1    44.17  ? 23  ASN C OD1 1 
ATOM   4738 N  ND2 . ASN C 1 27  ? -20.247 10.649  20.93   1    41.45  ? 23  ASN C ND2 1 
ATOM   4739 N  N   . LYS C 1 28  ? -16.904 14.11   21.932  1    47.22  ? 24  LYS C N   1 
ATOM   4740 C  CA  . LYS C 1 28  ? -15.683 14.728  21.437  1    53.99  ? 24  LYS C CA  1 
ATOM   4741 C  C   . LYS C 1 28  ? -15.381 14.318  19.996  1    55.75  ? 24  LYS C C   1 
ATOM   4742 O  O   . LYS C 1 28  ? -14.659 15.042  19.298  1    58.57  ? 24  LYS C O   1 
ATOM   4743 C  CB  . LYS C 1 28  ? -14.463 14.302  22.259  1    59.47  ? 24  LYS C CB  1 
ATOM   4744 C  CG  . LYS C 1 28  ? -14.336 14.948  23.623  1    64.65  ? 24  LYS C CG  1 
ATOM   4745 C  CD  . LYS C 1 28  ? -13.034 14.565  24.324  1    68.47  ? 24  LYS C CD  1 
ATOM   4746 C  CE  . LYS C 1 28  ? -13.27  14.454  25.811  1    74.44  ? 24  LYS C CE  1 
ATOM   4747 N  NZ  . LYS C 1 28  ? -12.055 14.154  26.573  1    76.86  ? 24  LYS C NZ  1 
ATOM   4748 N  N   . LEU C 1 29  ? -15.923 13.169  19.564  1    53.18  ? 25  LEU C N   1 
ATOM   4749 C  CA  . LEU C 1 29  ? -15.58  12.616  18.266  1    53.77  ? 25  LEU C CA  1 
ATOM   4750 C  C   . LEU C 1 29  ? -16.587 13.035  17.193  1    57.44  ? 25  LEU C C   1 
ATOM   4751 O  O   . LEU C 1 29  ? -16.16  13.278  16.064  1    61.91  ? 25  LEU C O   1 
ATOM   4752 C  CB  . LEU C 1 29  ? -15.467 11.102  18.385  1    49.51  ? 25  LEU C CB  1 
ATOM   4753 C  CG  . LEU C 1 29  ? -14.116 10.574  18.87   1    47.96  ? 25  LEU C CG  1 
ATOM   4754 C  CD1 . LEU C 1 29  ? -14.22  9.074   19.129  1    45.16  ? 25  LEU C CD1 1 
ATOM   4755 C  CD2 . LEU C 1 29  ? -13.051 10.892  17.865  1    47.85  ? 25  LEU C CD2 1 
ATOM   4756 N  N   . THR C 1 30  ? -17.896 13.094  17.539  1    53.28  ? 26  THR C N   1 
ATOM   4757 C  CA  . THR C 1 30  ? -18.965 13.353  16.581  1    50.04  ? 26  THR C CA  1 
ATOM   4758 C  C   . THR C 1 30  ? -19.48  14.788  16.664  1    52.46  ? 26  THR C C   1 
ATOM   4759 O  O   . THR C 1 30  ? -20.16  15.244  15.742  1    51.73  ? 26  THR C O   1 
ATOM   4760 C  CB  . THR C 1 30  ? -20.138 12.401  16.761  1    47.45  ? 26  THR C CB  1 
ATOM   4761 O  OG1 . THR C 1 30  ? -20.769 12.745  17.984  1    47.56  ? 26  THR C OG1 1 
ATOM   4762 C  CG2 . THR C 1 30  ? -19.746 10.934  16.779  1    49.13  ? 26  THR C CG2 1 
ATOM   4763 N  N   . GLY C 1 31  ? -19.224 15.483  17.786  1    52.7   ? 27  GLY C N   1 
ATOM   4764 C  CA  . GLY C 1 31  ? -19.749 16.831  17.988  1    52.56  ? 27  GLY C CA  1 
ATOM   4765 C  C   . GLY C 1 31  ? -21.167 16.855  18.589  1    55.5   ? 27  GLY C C   1 
ATOM   4766 O  O   . GLY C 1 31  ? -21.652 17.914  18.994  1    58.13  ? 27  GLY C O   1 
ATOM   4767 N  N   . GLU C 1 32  ? -21.844 15.694  18.661  1    50.97  ? 28  GLU C N   1 
ATOM   4768 C  CA  . GLU C 1 32  ? -23.175 15.644  19.24   1    49.56  ? 28  GLU C CA  1 
ATOM   4769 C  C   . GLU C 1 32  ? -23.138 16.2    20.67   1    53.38  ? 28  GLU C C   1 
ATOM   4770 O  O   . GLU C 1 32  ? -22.24  15.878  21.45   1    54.54  ? 28  GLU C O   1 
ATOM   4771 C  CB  . GLU C 1 32  ? -23.665 14.207  19.185  1    46.34  ? 28  GLU C CB  1 
ATOM   4772 C  CG  . GLU C 1 32  ? -25.118 14.022  19.634  1    46.04  ? 28  GLU C CG  1 
ATOM   4773 C  CD  . GLU C 1 32  ? -25.562 12.539  19.658  1    51.01  ? 28  GLU C CD  1 
ATOM   4774 O  OE1 . GLU C 1 32  ? -24.752 11.609  20.006  1    50.27  ? 28  GLU C OE1 1 
ATOM   4775 O  OE2 . GLU C 1 32  ? -26.762 12.288  19.364  1    50.2   ? 28  GLU C OE2 1 
ATOM   4776 N  N   . VAL C 1 33  ? -24.092 17.095  20.981  1    50.45  ? 29  VAL C N   1 
ATOM   4777 C  CA  . VAL C 1 33  ? -24.35  17.589  22.321  1    45.11  ? 29  VAL C CA  1 
ATOM   4778 C  C   . VAL C 1 33  ? -25.403 16.675  22.955  1    45.49  ? 29  VAL C C   1 
ATOM   4779 O  O   . VAL C 1 33  ? -26.403 16.359  22.315  1    43.49  ? 29  VAL C O   1 
ATOM   4780 C  CB  . VAL C 1 33  ? -24.866 19.04   22.242  1    45.48  ? 29  VAL C CB  1 
ATOM   4781 C  CG1 . VAL C 1 33  ? -25.063 19.615  23.645  1    44.77  ? 29  VAL C CG1 1 
ATOM   4782 C  CG2 . VAL C 1 33  ? -23.979 19.97   21.404  1    43.06  ? 29  VAL C CG2 1 
ATOM   4783 N  N   . VAL C 1 34  ? -25.202 16.266  24.219  1    42.61  ? 30  VAL C N   1 
ATOM   4784 C  CA  . VAL C 1 34  ? -26.103 15.308  24.858  1    41.21  ? 30  VAL C CA  1 
ATOM   4785 C  C   . VAL C 1 34  ? -26.422 15.774  26.282  1    41.71  ? 30  VAL C C   1 
ATOM   4786 O  O   . VAL C 1 34  ? -25.741 16.636  26.835  1    42.36  ? 30  VAL C O   1 
ATOM   4787 C  CB  . VAL C 1 34  ? -25.532 13.867  24.879  1    36.96  ? 30  VAL C CB  1 
ATOM   4788 C  CG1 . VAL C 1 34  ? -25.183 13.384  23.48   1    35.86  ? 30  VAL C CG1 1 
ATOM   4789 C  CG2 . VAL C 1 34  ? -24.3   13.719  25.766  1    35.96  ? 30  VAL C CG2 1 
ATOM   4790 N  N   . ALA C 1 35  ? -27.453 15.181  26.883  1    40.52  ? 31  ALA C N   1 
ATOM   4791 C  CA  . ALA C 1 35  ? -27.646 15.3    28.322  1    42.96  ? 31  ALA C CA  1 
ATOM   4792 C  C   . ALA C 1 35  ? -27.256 13.957  28.923  1    42.93  ? 31  ALA C C   1 
ATOM   4793 O  O   . ALA C 1 35  ? -27.632 12.936  28.371  1    42.04  ? 31  ALA C O   1 
ATOM   4794 C  CB  . ALA C 1 35  ? -29.09  15.66   28.654  1    36.17  ? 31  ALA C CB  1 
ATOM   4795 N  N   . LEU C 1 36  ? -26.451 13.976  29.988  1    45.75  ? 32  LEU C N   1 
ATOM   4796 C  CA  . LEU C 1 36  ? -25.989 12.777  30.678  1    47.44  ? 32  LEU C CA  1 
ATOM   4797 C  C   . LEU C 1 36  ? -26.668 12.689  32.042  1    48.77  ? 32  LEU C C   1 
ATOM   4798 O  O   . LEU C 1 36  ? -26.466 13.555  32.895  1    52.2   ? 32  LEU C O   1 
ATOM   4799 C  CB  . LEU C 1 36  ? -24.476 12.831  30.886  1    45.3   ? 32  LEU C CB  1 
ATOM   4800 C  CG  . LEU C 1 36  ? -23.59  12.833  29.645  1    46.98  ? 32  LEU C CG  1 
ATOM   4801 C  CD1 . LEU C 1 36  ? -22.145 12.814  30.124  1    50.03  ? 32  LEU C CD1 1 
ATOM   4802 C  CD2 . LEU C 1 36  ? -23.893 11.651  28.753  1    46.14  ? 32  LEU C CD2 1 
ATOM   4803 N  N   . LYS C 1 37  ? -27.448 11.634  32.249  1    46.58  ? 33  LYS C N   1 
ATOM   4804 C  CA  . LYS C 1 37  ? -27.995 11.337  33.563  1    46.77  ? 33  LYS C CA  1 
ATOM   4805 C  C   . LYS C 1 37  ? -27.054 10.339  34.239  1    44.84  ? 33  LYS C C   1 
ATOM   4806 O  O   . LYS C 1 37  ? -26.857 9.236   33.758  1    45.82  ? 33  LYS C O   1 
ATOM   4807 C  CB  . LYS C 1 37  ? -29.438 10.849  33.361  1    49.96  ? 33  LYS C CB  1 
ATOM   4808 C  CG  . LYS C 1 37  ? -30.385 10.968  34.531  1    57.65  ? 33  LYS C CG  1 
ATOM   4809 C  CD  . LYS C 1 37  ? -31.834 10.521  34.299  1    62.55  ? 33  LYS C CD  1 
ATOM   4810 C  CE  . LYS C 1 37  ? -32.809 11.533  33.759  1    62.11  ? 33  LYS C CE  1 
ATOM   4811 N  NZ  . LYS C 1 37  ? -34.202 11.098  33.951  1    60.63  ? 33  LYS C NZ  1 
ATOM   4812 N  N   . LYS C 1 38  ? -26.467 10.737  35.355  1    46.9   ? 34  LYS C N   1 
ATOM   4813 C  CA  . LYS C 1 38  ? -25.601 9.868   36.134  1    55.08  ? 34  LYS C CA  1 
ATOM   4814 C  C   . LYS C 1 38  ? -26.386 9.303   37.324  1    56.92  ? 34  LYS C C   1 
ATOM   4815 O  O   . LYS C 1 38  ? -26.928 10.051  38.134  1    66.41  ? 34  LYS C O   1 
ATOM   4816 C  CB  . LYS C 1 38  ? -24.334 10.627  36.551  1    55.13  ? 34  LYS C CB  1 
ATOM   4817 C  CG  . LYS C 1 38  ? -23.334 9.821   37.36   1    63.57  ? 34  LYS C CG  1 
ATOM   4818 C  CD  . LYS C 1 38  ? -22.204 10.585  38.055  1    66.51  ? 34  LYS C CD  1 
ATOM   4819 C  CE  . LYS C 1 38  ? -22.688 11.271  39.284  1    76.08  ? 34  LYS C CE  1 
ATOM   4820 N  NZ  . LYS C 1 38  ? -21.565 11.698  40.123  1    93.56  ? 34  LYS C NZ  1 
ATOM   4821 N  N   . ILE C 1 39  ? -26.473 7.969   37.348  1    57     ? 35  ILE C N   1 
ATOM   4822 C  CA  . ILE C 1 39  ? -27.249 7.251   38.396  1    55.78  ? 35  ILE C CA  1 
ATOM   4823 C  C   . ILE C 1 39  ? -26.275 6.392   39.207  1    58.26  ? 35  ILE C C   1 
ATOM   4824 O  O   . ILE C 1 39  ? -25.649 5.496   38.623  1    59.55  ? 35  ILE C O   1 
ATOM   4825 C  CB  . ILE C 1 39  ? -28.335 6.381   37.744  1    52.33  ? 35  ILE C CB  1 
ATOM   4826 C  CG1 . ILE C 1 39  ? -29.12  7.159   36.693  1    51.43  ? 35  ILE C CG1 1 
ATOM   4827 C  CG2 . ILE C 1 39  ? -29.246 5.755   38.798  1    50.67  ? 35  ILE C CG2 1 
ATOM   4828 C  CD1 . ILE C 1 39  ? -30.229 6.365   36.035  1    49.41  ? 35  ILE C CD1 1 
ATOM   4829 N  N   . ARG C 1 40  ? -26.166 6.672   40.502  1    64.18  ? 36  ARG C N   1 
ATOM   4830 C  CA  . ARG C 1 40  ? -25.269 5.893   41.387  1    71.13  ? 36  ARG C CA  1 
ATOM   4831 C  C   . ARG C 1 40  ? -25.876 4.51    41.63   1    69.93  ? 36  ARG C C   1 
ATOM   4832 O  O   . ARG C 1 40  ? -27.093 4.426   41.878  1    63.78  ? 36  ARG C O   1 
ATOM   4833 C  CB  . ARG C 1 40  ? -25.081 6.627   42.714  1    91.36  ? 36  ARG C CB  1 
ATOM   4834 C  CG  . ARG C 1 40  ? -24.484 8.022   42.598  1    127.89 ? 36  ARG C CG  1 
ATOM   4835 C  CD  . ARG C 1 40  ? -25.511 9.138   42.504  1    156.4  ? 36  ARG C CD  1 
ATOM   4836 N  NE  . ARG C 1 40  ? -24.924 10.38   41.992  1    161.83 ? 36  ARG C NE  1 
ATOM   4837 C  CZ  . ARG C 1 40  ? -24.926 11.528  42.657  1    151.43 ? 36  ARG C CZ  1 
ATOM   4838 N  NH1 . ARG C 1 40  ? -25.236 11.542  43.941  1    139.09 ? 36  ARG C NH1 1 
ATOM   4839 N  NH2 . ARG C 1 40  ? -24.622 12.654  42.039  1    147.66 ? 36  ARG C NH2 1 
ATOM   4840 N  N   . LEU C 1 41  ? -25.046 3.474   41.554  1    62.22  ? 37  LEU C N   1 
ATOM   4841 C  CA  . LEU C 1 41  ? -25.533 2.103   41.823  1    58.93  ? 37  LEU C CA  1 
ATOM   4842 C  C   . LEU C 1 41  ? -25.163 1.72    43.263  1    68.87  ? 37  LEU C C   1 
ATOM   4843 O  O   . LEU C 1 41  ? -23.98  1.848   43.624  1    75.27  ? 37  LEU C O   1 
ATOM   4844 C  CB  . LEU C 1 41  ? -24.982 1.147   40.771  1    58.04  ? 37  LEU C CB  1 
ATOM   4845 C  CG  . LEU C 1 41  ? -25.334 1.472   39.318  1    53.32  ? 37  LEU C CG  1 
ATOM   4846 C  CD1 . LEU C 1 41  ? -24.822 0.378   38.406  1    49.06  ? 37  LEU C CD1 1 
ATOM   4847 C  CD2 . LEU C 1 41  ? -26.83  1.642   39.163  1    49.62  ? 37  LEU C CD2 1 
ATOM   4848 N  N   . ASP C 1 42  ? -26.146 1.313   44.058  1    67.03  ? 38  ASP C N   1 
ATOM   4849 C  CA  . ASP C 1 42  ? -25.966 0.938   45.454  1    71.81  ? 38  ASP C CA  1 
ATOM   4850 C  C   . ASP C 1 42  ? -25.415 -0.482  45.542  1    63.36  ? 38  ASP C C   1 
ATOM   4851 O  O   . ASP C 1 42  ? -26.175 -1.401  45.874  1    63.06  ? 38  ASP C O   1 
ATOM   4852 C  CB  . ASP C 1 42  ? -27.286 1.079   46.201  1    73.3   ? 38  ASP C CB  1 
ATOM   4853 C  CG  . ASP C 1 42  ? -27.773 2.512   46.306  1    76.66  ? 38  ASP C CG  1 
ATOM   4854 O  OD1 . ASP C 1 42  ? -26.898 3.368   46.539  1    85.89  ? 38  ASP C OD1 1 
ATOM   4855 O  OD2 . ASP C 1 42  ? -28.996 2.744   46.162  1    77.22  ? 38  ASP C OD2 1 
ATOM   4856 N  N   . THR C 1 43  ? -24.101 -0.632  45.295  1    55.73  ? 39  THR C N   1 
ATOM   4857 C  CA  . THR C 1 43  ? -23.551 -1.939  44.947  1    55.81  ? 39  THR C CA  1 
ATOM   4858 C  C   . THR C 1 43  ? -23.404 -2.874  46.147  1    58.51  ? 39  THR C C   1 
ATOM   4859 O  O   . THR C 1 43  ? -23.084 -4.042  45.969  1    64.06  ? 39  THR C O   1 
ATOM   4860 C  CB  . THR C 1 43  ? -22.226 -1.817  44.191  1    57.24  ? 39  THR C CB  1 
ATOM   4861 O  OG1 . THR C 1 43  ? -21.239 -1.264  45.056  1    60.51  ? 39  THR C OG1 1 
ATOM   4862 C  CG2 . THR C 1 43  ? -22.325 -1      42.908  1    52.79  ? 39  THR C CG2 1 
ATOM   4863 N  N   . GLU C 1 44  ? -23.586 -2.375  47.375  1    58.75  ? 40  GLU C N   1 
ATOM   4864 C  CA  . GLU C 1 44  ? -23.54  -3.241  48.535  1    60.89  ? 40  GLU C CA  1 
ATOM   4865 C  C   . GLU C 1 44  ? -24.903 -3.335  49.223  1    61.71  ? 40  GLU C C   1 
ATOM   4866 O  O   . GLU C 1 44  ? -25.046 -4.084  50.186  1    68.56  ? 40  GLU C O   1 
ATOM   4867 C  CB  . GLU C 1 44  ? -22.492 -2.747  49.521  1    65.26  ? 40  GLU C CB  1 
ATOM   4868 C  CG  . GLU C 1 44  ? -21.063 -2.922  49.014  1    70.16  ? 40  GLU C CG  1 
ATOM   4869 C  CD  . GLU C 1 44  ? -20.686 -1.878  47.98   1    68.18  ? 40  GLU C CD  1 
ATOM   4870 O  OE1 . GLU C 1 44  ? -20.099 -2.28   46.94   1    68.68  ? 40  GLU C OE1 1 
ATOM   4871 O  OE2 . GLU C 1 44  ? -21     -0.682  48.213  1    66.86  ? 40  GLU C OE2 1 
ATOM   4872 N  N   . THR C 1 45  ? -25.902 -2.602  48.725  1    56.97  ? 41  THR C N   1 
ATOM   4873 C  CA  . THR C 1 45  ? -27.155 -2.473  49.443  1    57.9   ? 41  THR C CA  1 
ATOM   4874 C  C   . THR C 1 45  ? -28.299 -2.811  48.506  1    55.58  ? 41  THR C C   1 
ATOM   4875 O  O   . THR C 1 45  ? -28.668 -3.969  48.475  1    61.49  ? 41  THR C O   1 
ATOM   4876 C  CB  . THR C 1 45  ? -27.269 -1.128  50.176  1    58.45  ? 41  THR C CB  1 
ATOM   4877 O  OG1 . THR C 1 45  ? -27.051 -0.037  49.275  1    56.55  ? 41  THR C OG1 1 
ATOM   4878 C  CG2 . THR C 1 45  ? -26.293 -1.059  51.345  1    58.6   ? 41  THR C CG2 1 
ATOM   4879 N  N   . GLU C 1 46  ? -28.797 -1.834  47.742  1    53.38  ? 42  GLU C N   1 
ATOM   4880 C  CA  . GLU C 1 46  ? -30.075 -1.936  47.04   1    54.1   ? 42  GLU C CA  1 
ATOM   4881 C  C   . GLU C 1 46  ? -29.916 -2.183  45.536  1    49.81  ? 42  GLU C C   1 
ATOM   4882 O  O   . GLU C 1 46  ? -30.889 -2.508  44.888  1    48.67  ? 42  GLU C O   1 
ATOM   4883 C  CB  . GLU C 1 46  ? -30.993 -0.751  47.358  1    56.13  ? 42  GLU C CB  1 
ATOM   4884 C  CG  . GLU C 1 46  ? -31.528 -0.798  48.798  1    68.49  ? 42  GLU C CG  1 
ATOM   4885 C  CD  . GLU C 1 46  ? -31.806 -2.156  49.478  1    76.42  ? 42  GLU C CD  1 
ATOM   4886 O  OE1 . GLU C 1 46  ? -32.684 -2.965  49.058  1    71.37  ? 42  GLU C OE1 1 
ATOM   4887 O  OE2 . GLU C 1 46  ? -31.1   -2.432  50.481  1    93.97  ? 42  GLU C OE2 1 
ATOM   4888 N  N   . GLY C 1 47  ? -28.709 -2.051  44.971  1    49.61  ? 43  GLY C N   1 
ATOM   4889 C  CA  . GLY C 1 47  ? -28.477 -2.345  43.563  1    44.95  ? 43  GLY C CA  1 
ATOM   4890 C  C   . GLY C 1 47  ? -29.032 -1.233  42.686  1    45.58  ? 43  GLY C C   1 
ATOM   4891 O  O   . GLY C 1 47  ? -28.991 -0.074  43.075  1    52.25  ? 43  GLY C O   1 
ATOM   4892 N  N   . VAL C 1 48  ? -29.602 -1.586  41.53   1    42.14  ? 44  VAL C N   1 
ATOM   4893 C  CA  . VAL C 1 48  ? -30.014 -0.606  40.545  1    39.68  ? 44  VAL C CA  1 
ATOM   4894 C  C   . VAL C 1 48  ? -31.412 -0.128  40.92   1    42.77  ? 44  VAL C C   1 
ATOM   4895 O  O   . VAL C 1 48  ? -32.305 -0.952  41.11   1    44.66  ? 44  VAL C O   1 
ATOM   4896 C  CB  . VAL C 1 48  ? -30.067 -1.234  39.133  1    36.02  ? 44  VAL C CB  1 
ATOM   4897 C  CG1 . VAL C 1 48  ? -30.575 -0.264  38.106  1    32.14  ? 44  VAL C CG1 1 
ATOM   4898 C  CG2 . VAL C 1 48  ? -28.741 -1.769  38.675  1    35.72  ? 44  VAL C CG2 1 
ATOM   4899 N  N   . PRO C 1 49  ? -31.665 1.201   40.983  1    42.3   ? 45  PRO C N   1 
ATOM   4900 C  CA  . PRO C 1 49  ? -32.954 1.714   41.451  1    39.71  ? 45  PRO C CA  1 
ATOM   4901 C  C   . PRO C 1 49  ? -34.099 1.321   40.527  1    43.87  ? 45  PRO C C   1 
ATOM   4902 O  O   . PRO C 1 49  ? -33.976 1.366   39.288  1    47.92  ? 45  PRO C O   1 
ATOM   4903 C  CB  . PRO C 1 49  ? -32.794 3.238   41.531  1    36.94  ? 45  PRO C CB  1 
ATOM   4904 C  CG  . PRO C 1 49  ? -31.327 3.482   41.35   1    39.67  ? 45  PRO C CG  1 
ATOM   4905 C  CD  . PRO C 1 49  ? -30.716 2.266   40.629  1    40.33  ? 45  PRO C CD  1 
ATOM   4906 N  N   . SER C 1 50  ? -35.251 1.021   41.142  1    43.23  ? 46  SER C N   1 
ATOM   4907 C  CA  . SER C 1 50  ? -36.437 0.696   40.363  1    45.59  ? 46  SER C CA  1 
ATOM   4908 C  C   . SER C 1 50  ? -36.834 1.821   39.406  1    43.48  ? 46  SER C C   1 
ATOM   4909 O  O   . SER C 1 50  ? -37.333 1.515   38.317  1    43.61  ? 46  SER C O   1 
ATOM   4910 C  CB  . SER C 1 50  ? -37.552 0.235   41.222  1    46.96  ? 46  SER C CB  1 
ATOM   4911 O  OG  . SER C 1 50  ? -37.868 1.24    42.161  1    57.51  ? 46  SER C OG  1 
ATOM   4912 N  N   . THR C 1 51  ? -36.588 3.095   39.779  1    45.18  ? 47  THR C N   1 
ATOM   4913 C  CA  . THR C 1 51  ? -36.95  4.22    38.904  1    45.82  ? 47  THR C CA  1 
ATOM   4914 C  C   . THR C 1 51  ? -36.134 4.168   37.627  1    41.45  ? 47  THR C C   1 
ATOM   4915 O  O   . THR C 1 51  ? -36.652 4.577   36.595  1    47.06  ? 47  THR C O   1 
ATOM   4916 C  CB  . THR C 1 51  ? -36.862 5.63    39.494  1    49.05  ? 47  THR C CB  1 
ATOM   4917 O  OG1 . THR C 1 51  ? -35.564 5.792   40.034  1    57.54  ? 47  THR C OG1 1 
ATOM   4918 C  CG2 . THR C 1 51  ? -37.813 5.862   40.652  1    60.47  ? 47  THR C CG2 1 
ATOM   4919 N  N   . ALA C 1 52  ? -34.879 3.674   37.707  1    37.55  ? 48  ALA C N   1 
ATOM   4920 C  CA  . ALA C 1 52  ? -33.996 3.646   36.555  1    34.67  ? 48  ALA C CA  1 
ATOM   4921 C  C   . ALA C 1 52  ? -34.331 2.458   35.644  1    39.16  ? 48  ALA C C   1 
ATOM   4922 O  O   . ALA C 1 52  ? -34.339 2.586   34.424  1    41.79  ? 48  ALA C O   1 
ATOM   4923 C  CB  . ALA C 1 52  ? -32.565 3.63    37      1    33.39  ? 48  ALA C CB  1 
ATOM   4924 N  N   . ILE C 1 53  ? -34.626 1.3     36.244  1    38.17  ? 49  ILE C N   1 
ATOM   4925 C  CA  . ILE C 1 53  ? -35.072 0.133   35.497  1    38.02  ? 49  ILE C CA  1 
ATOM   4926 C  C   . ILE C 1 53  ? -36.336 0.445   34.689  1    39.53  ? 49  ILE C C   1 
ATOM   4927 O  O   . ILE C 1 53  ? -36.43  0.115   33.507  1    37.88  ? 49  ILE C O   1 
ATOM   4928 C  CB  . ILE C 1 53  ? -35.293 -1.032  36.467  1    36.15  ? 49  ILE C CB  1 
ATOM   4929 C  CG1 . ILE C 1 53  ? -33.98  -1.497  37.036  1    34.97  ? 49  ILE C CG1 1 
ATOM   4930 C  CG2 . ILE C 1 53  ? -36.045 -2.16   35.756  1    36.19  ? 49  ILE C CG2 1 
ATOM   4931 C  CD1 . ILE C 1 53  ? -34.122 -2.268  38.326  1    36.58  ? 49  ILE C CD1 1 
ATOM   4932 N  N   . ARG C 1 54  ? -37.304 1.107   35.328  1    41.81  ? 50  ARG C N   1 
ATOM   4933 C  CA  . ARG C 1 54  ? -38.489 1.541   34.606  1    43.3   ? 50  ARG C CA  1 
ATOM   4934 C  C   . ARG C 1 54  ? -38.154 2.578   33.531  1    45.6   ? 50  ARG C C   1 
ATOM   4935 O  O   . ARG C 1 54  ? -38.598 2.418   32.398  1    45.1   ? 50  ARG C O   1 
ATOM   4936 C  CB  . ARG C 1 54  ? -39.523 2.082   35.59   1    42.9   ? 50  ARG C CB  1 
ATOM   4937 C  CG  . ARG C 1 54  ? -40.256 0.951   36.297  1    44.2   ? 50  ARG C CG  1 
ATOM   4938 C  CD  . ARG C 1 54  ? -41.301 1.515   37.22   1    46.79  ? 50  ARG C CD  1 
ATOM   4939 N  NE  . ARG C 1 54  ? -41.982 0.469   37.983  1    48.96  ? 50  ARG C NE  1 
ATOM   4940 C  CZ  . ARG C 1 54  ? -42.768 0.727   39.002  1    51.33  ? 50  ARG C CZ  1 
ATOM   4941 N  NH1 . ARG C 1 54  ? -43.029 1.991   39.34   1    53.83  ? 50  ARG C NH1 1 
ATOM   4942 N  NH2 . ARG C 1 54  ? -43.31  -0.279  39.657  1    49.66  ? 50  ARG C NH2 1 
ATOM   4943 N  N   . GLU C 1 55  ? -37.385 3.628   33.878  1    41.06  ? 51  GLU C N   1 
ATOM   4944 C  CA  . GLU C 1 55  ? -37.095 4.669   32.916  1    42.45  ? 51  GLU C CA  1 
ATOM   4945 C  C   . GLU C 1 55  ? -36.388 4.087   31.688  1    45.66  ? 51  GLU C C   1 
ATOM   4946 O  O   . GLU C 1 55  ? -36.771 4.385   30.56   1    46.9   ? 51  GLU C O   1 
ATOM   4947 C  CB  . GLU C 1 55  ? -36.29  5.818   33.519  1    46.93  ? 51  GLU C CB  1 
ATOM   4948 C  CG  . GLU C 1 55  ? -35.907 6.863   32.474  1    49.28  ? 51  GLU C CG  1 
ATOM   4949 C  CD  . GLU C 1 55  ? -35.428 8.207   33.001  1    52.86  ? 51  GLU C CD  1 
ATOM   4950 O  OE1 . GLU C 1 55  ? -34.99  8.258   34.161  1    49.95  ? 51  GLU C OE1 1 
ATOM   4951 O  OE2 . GLU C 1 55  ? -35.557 9.22    32.271  1    57.05  ? 51  GLU C OE2 1 
ATOM   4952 N  N   . ILE C 1 56  ? -35.354 3.265   31.896  1    43.66  ? 52  ILE C N   1 
ATOM   4953 C  CA  . ILE C 1 56  ? -34.563 2.746   30.797  1    39.36  ? 52  ILE C CA  1 
ATOM   4954 C  C   . ILE C 1 56  ? -35.403 1.796   29.949  1    39.7   ? 52  ILE C C   1 
ATOM   4955 O  O   . ILE C 1 56  ? -35.444 1.953   28.721  1    41.95  ? 52  ILE C O   1 
ATOM   4956 C  CB  . ILE C 1 56  ? -33.249 2.103   31.287  1    40.54  ? 52  ILE C CB  1 
ATOM   4957 C  CG1 . ILE C 1 56  ? -32.367 3.137   31.996  1    38.78  ? 52  ILE C CG1 1 
ATOM   4958 C  CG2 . ILE C 1 56  ? -32.503 1.413   30.122  1    42.07  ? 52  ILE C CG2 1 
ATOM   4959 C  CD1 . ILE C 1 56  ? -31.391 2.57    33.029  1    40.14  ? 52  ILE C CD1 1 
ATOM   4960 N  N   . SER C 1 57  ? -36.054 0.815   30.586  1    40.17  ? 53  SER C N   1 
ATOM   4961 C  CA  . SER C 1 57  ? -36.799 -0.21   29.855  1    45.35  ? 53  SER C CA  1 
ATOM   4962 C  C   . SER C 1 57  ? -37.919 0.401   29.002  1    49.46  ? 53  SER C C   1 
ATOM   4963 O  O   . SER C 1 57  ? -38.094 0.028   27.835  1    48.76  ? 53  SER C O   1 
ATOM   4964 C  CB  . SER C 1 57  ? -37.322 -1.28   30.771  1    44.91  ? 53  SER C CB  1 
ATOM   4965 O  OG  . SER C 1 57  ? -38.027 -0.692  31.859  1    51.74  ? 53  SER C OG  1 
ATOM   4966 N  N   . LEU C 1 58  ? -38.657 1.359   29.583  1    44.42  ? 54  LEU C N   1 
ATOM   4967 C  CA  . LEU C 1 58  ? -39.801 1.952   28.916  1    45     ? 54  LEU C CA  1 
ATOM   4968 C  C   . LEU C 1 58  ? -39.35  2.864   27.774  1    47.62  ? 54  LEU C C   1 
ATOM   4969 O  O   . LEU C 1 58  ? -39.943 2.815   26.694  1    54.12  ? 54  LEU C O   1 
ATOM   4970 C  CB  . LEU C 1 58  ? -40.758 2.621   29.9    1    41.92  ? 54  LEU C CB  1 
ATOM   4971 C  CG  . LEU C 1 58  ? -41.287 1.68    30.996  1    42.12  ? 54  LEU C CG  1 
ATOM   4972 C  CD1 . LEU C 1 58  ? -42.139 2.354   32.036  1    38.82  ? 54  LEU C CD1 1 
ATOM   4973 C  CD2 . LEU C 1 58  ? -42.024 0.518   30.409  1    39.01  ? 54  LEU C CD2 1 
ATOM   4974 N  N   . LEU C 1 59  ? -38.289 3.649   27.988  1    41.31  ? 55  LEU C N   1 
ATOM   4975 C  CA  . LEU C 1 59  ? -37.76  4.517   26.939  1    44.45  ? 55  LEU C CA  1 
ATOM   4976 C  C   . LEU C 1 59  ? -37.15  3.714   25.779  1    44.5   ? 55  LEU C C   1 
ATOM   4977 O  O   . LEU C 1 59  ? -37.111 4.196   24.649  1    48.13  ? 55  LEU C O   1 
ATOM   4978 C  CB  . LEU C 1 59  ? -36.746 5.527   27.489  1    40.91  ? 55  LEU C CB  1 
ATOM   4979 C  CG  . LEU C 1 59  ? -37.272 6.701   28.313  1    41.25  ? 55  LEU C CG  1 
ATOM   4980 C  CD1 . LEU C 1 59  ? -36.124 7.48    28.892  1    44.47  ? 55  LEU C CD1 1 
ATOM   4981 C  CD2 . LEU C 1 59  ? -38.163 7.626   27.539  1    41.74  ? 55  LEU C CD2 1 
ATOM   4982 N  N   . LYS C 1 60  ? -36.614 2.52    26.047  1    49.29  ? 56  LYS C N   1 
ATOM   4983 C  CA  . LYS C 1 60  ? -36.041 1.675   25.006  1    61.39  ? 56  LYS C CA  1 
ATOM   4984 C  C   . LYS C 1 60  ? -37.119 1.266   23.994  1    57.99  ? 56  LYS C C   1 
ATOM   4985 O  O   . LYS C 1 60  ? -36.833 1.087   22.816  1    59.83  ? 56  LYS C O   1 
ATOM   4986 C  CB  . LYS C 1 60  ? -35.214 0.523   25.6    1    61.77  ? 56  LYS C CB  1 
ATOM   4987 C  CG  . LYS C 1 60  ? -33.736 0.839   25.718  1    65.28  ? 56  LYS C CG  1 
ATOM   4988 C  CD  . LYS C 1 60  ? -32.908 -0.145  26.54   1    82.35  ? 56  LYS C CD  1 
ATOM   4989 C  CE  . LYS C 1 60  ? -31.475 -0.316  26.02   1    94.15  ? 56  LYS C CE  1 
ATOM   4990 N  NZ  . LYS C 1 60  ? -30.375 -0.351  27.019  1    83.6   ? 56  LYS C NZ  1 
ATOM   4991 N  N   . GLU C 1 61  ? -38.36  1.156   24.464  1    54.68  ? 57  GLU C N   1 
ATOM   4992 C  CA  . GLU C 1 61  ? -39.494 0.823   23.626  1    54.73  ? 57  GLU C CA  1 
ATOM   4993 C  C   . GLU C 1 61  ? -40.148 2.043   22.969  1    60.05  ? 57  GLU C C   1 
ATOM   4994 O  O   . GLU C 1 61  ? -40.763 1.899   21.916  1    74.25  ? 57  GLU C O   1 
ATOM   4995 C  CB  . GLU C 1 61  ? -40.539 0.143   24.507  1    63.19  ? 57  GLU C CB  1 
ATOM   4996 C  CG  . GLU C 1 61  ? -40.149 -1.282  24.88   1    62.22  ? 57  GLU C CG  1 
ATOM   4997 C  CD  . GLU C 1 61  ? -41.31  -2.079  25.419  1    63     ? 57  GLU C CD  1 
ATOM   4998 O  OE1 . GLU C 1 61  ? -42.439 -1.543  25.373  1    61.24  ? 57  GLU C OE1 1 
ATOM   4999 O  OE2 . GLU C 1 61  ? -41.096 -3.236  25.852  1    78.88  ? 57  GLU C OE2 1 
ATOM   5000 N  N   . LEU C 1 62  ? -40.061 3.23    23.576  1    50.21  ? 58  LEU C N   1 
ATOM   5001 C  CA  . LEU C 1 62  ? -40.827 4.359   23.08   1    50.56  ? 58  LEU C CA  1 
ATOM   5002 C  C   . LEU C 1 62  ? -40.005 5.235   22.122  1    49.05  ? 58  LEU C C   1 
ATOM   5003 O  O   . LEU C 1 62  ? -39.367 6.189   22.53   1    58.12  ? 58  LEU C O   1 
ATOM   5004 C  CB  . LEU C 1 62  ? -41.356 5.137   24.29   1    49.79  ? 58  LEU C CB  1 
ATOM   5005 C  CG  . LEU C 1 62  ? -42.385 4.425   25.171  1    51.86  ? 58  LEU C CG  1 
ATOM   5006 C  CD1 . LEU C 1 62  ? -42.39  5.026   26.55   1    48.1   ? 58  LEU C CD1 1 
ATOM   5007 C  CD2 . LEU C 1 62  ? -43.785 4.499   24.612  1    53.7   ? 58  LEU C CD2 1 
ATOM   5008 N  N   . ASN C 1 63  ? -40.062 4.957   20.82   1    51.61  ? 59  ASN C N   1 
ATOM   5009 C  CA  . ASN C 1 63  ? -39.396 5.772   19.817  1    57.63  ? 59  ASN C CA  1 
ATOM   5010 C  C   . ASN C 1 63  ? -40.424 6.618   19.07   1    54.65  ? 59  ASN C C   1 
ATOM   5011 O  O   . ASN C 1 63  ? -41.194 6.092   18.27   1    56.02  ? 59  ASN C O   1 
ATOM   5012 C  CB  . ASN C 1 63  ? -38.439 4.93    18.971  1    73.82  ? 59  ASN C CB  1 
ATOM   5013 C  CG  . ASN C 1 63  ? -37.232 4.476   19.779  1    98.43  ? 59  ASN C CG  1 
ATOM   5014 O  OD1 . ASN C 1 63  ? -37.183 3.365   20.333  1    106.49 ? 59  ASN C OD1 1 
ATOM   5015 N  ND2 . ASN C 1 63  ? -36.258 5.362   19.932  1    109.89 ? 59  ASN C ND2 1 
ATOM   5016 N  N   . HIS C 1 64  ? -40.451 7.929   19.372  1    51.37  ? 60  HIS C N   1 
ATOM   5017 C  CA  . HIS C 1 64  ? -41.397 8.888   18.8    1    47.12  ? 60  HIS C CA  1 
ATOM   5018 C  C   . HIS C 1 64  ? -40.776 10.289  18.787  1    46.83  ? 60  HIS C C   1 
ATOM   5019 O  O   . HIS C 1 64  ? -39.942 10.629  19.628  1    43.18  ? 60  HIS C O   1 
ATOM   5020 C  CB  . HIS C 1 64  ? -42.716 8.882   19.579  1    43.77  ? 60  HIS C CB  1 
ATOM   5021 C  CG  . HIS C 1 64  ? -43.803 9.656   18.915  1    47.73  ? 60  HIS C CG  1 
ATOM   5022 N  ND1 . HIS C 1 64  ? -43.976 11.014  19.121  1    48.74  ? 60  HIS C ND1 1 
ATOM   5023 C  CD2 . HIS C 1 64  ? -44.797 9.276   18.086  1    46.65  ? 60  HIS C CD2 1 
ATOM   5024 C  CE1 . HIS C 1 64  ? -45.011 11.448  18.404  1    47.78  ? 60  HIS C CE1 1 
ATOM   5025 N  NE2 . HIS C 1 64  ? -45.54  10.414  17.78   1    47.21  ? 60  HIS C NE2 1 
ATOM   5026 N  N   . PRO C 1 65  ? -41.096 11.134  17.787  1    46.26  ? 61  PRO C N   1 
ATOM   5027 C  CA  . PRO C 1 65  ? -40.501 12.475  17.72   1    44.99  ? 61  PRO C CA  1 
ATOM   5028 C  C   . PRO C 1 65  ? -40.812 13.348  18.922  1    46.45  ? 61  PRO C C   1 
ATOM   5029 O  O   . PRO C 1 65  ? -40.059 14.287  19.157  1    46.4   ? 61  PRO C O   1 
ATOM   5030 C  CB  . PRO C 1 65  ? -40.945 13.138  16.425  1    43.75  ? 61  PRO C CB  1 
ATOM   5031 C  CG  . PRO C 1 65  ? -41.896 12.109  15.79   1    45.17  ? 61  PRO C CG  1 
ATOM   5032 C  CD  . PRO C 1 65  ? -41.947 10.813  16.635  1    41.38  ? 61  PRO C CD  1 
ATOM   5033 N  N   . ASN C 1 66  ? -41.891 13.021  19.669  1    45.6   ? 62  ASN C N   1 
ATOM   5034 C  CA  . ASN C 1 66  ? -42.357 13.83   20.794  1    43.08  ? 62  ASN C CA  1 
ATOM   5035 C  C   . ASN C 1 66  ? -42.064 13.163  22.147  1    44.74  ? 62  ASN C C   1 
ATOM   5036 O  O   . ASN C 1 66  ? -42.553 13.607  23.189  1    43.64  ? 62  ASN C O   1 
ATOM   5037 C  CB  . ASN C 1 66  ? -43.808 14.248  20.607  1    39.2   ? 62  ASN C CB  1 
ATOM   5038 C  CG  . ASN C 1 66  ? -43.997 15.152  19.405  1    43.35  ? 62  ASN C CG  1 
ATOM   5039 O  OD1 . ASN C 1 66  ? -44.737 14.788  18.491  1    45.98  ? 62  ASN C OD1 1 
ATOM   5040 N  ND2 . ASN C 1 66  ? -43.353 16.315  19.355  1    38.11  ? 62  ASN C ND2 1 
ATOM   5041 N  N   . ILE C 1 67  ? -41.231 12.116  22.151  1    41.36  ? 63  ILE C N   1 
ATOM   5042 C  CA  . ILE C 1 67  ? -40.715 11.548  23.39   1    39.28  ? 63  ILE C CA  1 
ATOM   5043 C  C   . ILE C 1 67  ? -39.201 11.635  23.334  1    40.72  ? 63  ILE C C   1 
ATOM   5044 O  O   . ILE C 1 67  ? -38.602 11.255  22.321  1    45.82  ? 63  ILE C O   1 
ATOM   5045 C  CB  . ILE C 1 67  ? -41.171 10.089  23.554  1    38.08  ? 63  ILE C CB  1 
ATOM   5046 C  CG1 . ILE C 1 67  ? -42.687 9.978   23.624  1    39.83  ? 63  ILE C CG1 1 
ATOM   5047 C  CG2 . ILE C 1 67  ? -40.511 9.432   24.764  1    37.96  ? 63  ILE C CG2 1 
ATOM   5048 C  CD1 . ILE C 1 67  ? -43.179 8.553   23.43   1    38.82  ? 63  ILE C CD1 1 
ATOM   5049 N  N   . VAL C 1 68  ? -38.611 12.137  24.422  1    42.53  ? 64  VAL C N   1 
ATOM   5050 C  CA  . VAL C 1 68  ? -37.127 12.283  24.528  1    40.25  ? 64  VAL C CA  1 
ATOM   5051 C  C   . VAL C 1 68  ? -36.442 10.961  24.155  1    41.07  ? 64  VAL C C   1 
ATOM   5052 O  O   . VAL C 1 68  ? -36.945 9.888   24.528  1    34.98  ? 64  VAL C O   1 
ATOM   5053 C  CB  . VAL C 1 68  ? -36.688 12.786  25.92   1    37.17  ? 64  VAL C CB  1 
ATOM   5054 C  CG1 . VAL C 1 68  ? -36.949 11.77   27.023  1    32.92  ? 64  VAL C CG1 1 
ATOM   5055 C  CG2 . VAL C 1 68  ? -35.242 13.261  25.939  1    37.37  ? 64  VAL C CG2 1 
ATOM   5056 N  N   . LYS C 1 69  ? -35.312 11.056  23.464  1    40.62  ? 65  LYS C N   1 
ATOM   5057 C  CA  . LYS C 1 69  ? -34.65  9.829   22.972  1    46.96  ? 65  LYS C CA  1 
ATOM   5058 C  C   . LYS C 1 69  ? -33.508 9.399   23.894  1    45.87  ? 65  LYS C C   1 
ATOM   5059 O  O   . LYS C 1 69  ? -32.628 10.227  24.172  1    43.15  ? 65  LYS C O   1 
ATOM   5060 C  CB  . LYS C 1 69  ? -34.181 10.041  21.529  1    53.79  ? 65  LYS C CB  1 
ATOM   5061 C  CG  . LYS C 1 69  ? -33.161 9.05    21.008  1    68.64  ? 65  LYS C CG  1 
ATOM   5062 C  CD  . LYS C 1 69  ? -33.752 7.741   20.506  1    92.23  ? 65  LYS C CD  1 
ATOM   5063 C  CE  . LYS C 1 69  ? -32.715 6.887   19.855  1    84.73  ? 65  LYS C CE  1 
ATOM   5064 N  NZ  . LYS C 1 69  ? -33.14  5.489   19.766  1    81.95  ? 65  LYS C NZ  1 
ATOM   5065 N  N   . LEU C 1 70  ? -33.578 8.162   24.386  1    45.89  ? 66  LEU C N   1 
ATOM   5066 C  CA  . LEU C 1 70  ? -32.446 7.593   25.15   1    43.59  ? 66  LEU C CA  1 
ATOM   5067 C  C   . LEU C 1 70  ? -31.514 7.044   24.072  1    46.11  ? 66  LEU C C   1 
ATOM   5068 O  O   . LEU C 1 70  ? -31.899 6.099   23.376  1    46.9   ? 66  LEU C O   1 
ATOM   5069 C  CB  . LEU C 1 70  ? -32.857 6.525   26.159  1    38.4   ? 66  LEU C CB  1 
ATOM   5070 C  CG  . LEU C 1 70  ? -31.737 5.944   27.023  1    41.88  ? 66  LEU C CG  1 
ATOM   5071 C  CD1 . LEU C 1 70  ? -31.052 7.049   27.797  1    40.48  ? 66  LEU C CD1 1 
ATOM   5072 C  CD2 . LEU C 1 70  ? -32.331 4.919   27.965  1    41.34  ? 66  LEU C CD2 1 
ATOM   5073 N  N   . LEU C 1 71  ? -30.365 7.673   23.913  1    46.8   ? 67  LEU C N   1 
ATOM   5074 C  CA  . LEU C 1 71  ? -29.409 7.29    22.874  1    45.3   ? 67  LEU C CA  1 
ATOM   5075 C  C   . LEU C 1 71  ? -28.546 6.09    23.298  1    46.26  ? 67  LEU C C   1 
ATOM   5076 O  O   . LEU C 1 71  ? -28.174 5.276   22.447  1    47.35  ? 67  LEU C O   1 
ATOM   5077 C  CB  . LEU C 1 71  ? -28.515 8.482   22.54   1    41.48  ? 67  LEU C CB  1 
ATOM   5078 C  CG  . LEU C 1 71  ? -29.246 9.766   22.143  1    42.6   ? 67  LEU C CG  1 
ATOM   5079 C  CD1 . LEU C 1 71  ? -28.284 10.945  22.261  1    40.68  ? 67  LEU C CD1 1 
ATOM   5080 C  CD2 . LEU C 1 71  ? -29.749 9.621   20.705  1    40.42  ? 67  LEU C CD2 1 
ATOM   5081 N  N   . ASP C 1 72  ? -28.182 6.004   24.588  1    40.59  ? 68  ASP C N   1 
ATOM   5082 C  CA  . ASP C 1 72  ? -27.228 5.004   25.02   1    39.86  ? 68  ASP C CA  1 
ATOM   5083 C  C   . ASP C 1 72  ? -27.342 4.792   26.531  1    42.83  ? 68  ASP C C   1 
ATOM   5084 O  O   . ASP C 1 72  ? -27.886 5.647   27.236  1    41.32  ? 68  ASP C O   1 
ATOM   5085 C  CB  . ASP C 1 72  ? -25.819 5.417   24.628  1    39.15  ? 68  ASP C CB  1 
ATOM   5086 C  CG  . ASP C 1 72  ? -24.847 4.259   24.482  1    44.73  ? 68  ASP C CG  1 
ATOM   5087 O  OD1 . ASP C 1 72  ? -25.256 3.117   24.788  1    45.04  ? 68  ASP C OD1 1 
ATOM   5088 O  OD2 . ASP C 1 72  ? -23.683 4.497   24.062  1    48.1   ? 68  ASP C OD2 1 
ATOM   5089 N  N   . VAL C 1 73  ? -26.787 3.663   27.011  1    43.15  ? 69  VAL C N   1 
ATOM   5090 C  CA  . VAL C 1 73  ? -26.694 3.317   28.424  1    44.53  ? 69  VAL C CA  1 
ATOM   5091 C  C   . VAL C 1 73  ? -25.285 2.791   28.698  1    44.44  ? 69  VAL C C   1 
ATOM   5092 O  O   . VAL C 1 73  ? -24.996 1.637   28.392  1    47.75  ? 69  VAL C O   1 
ATOM   5093 C  CB  . VAL C 1 73  ? -27.767 2.307   28.892  1    40.69  ? 69  VAL C CB  1 
ATOM   5094 C  CG1 . VAL C 1 73  ? -27.595 1.973   30.376  1    44.23  ? 69  VAL C CG1 1 
ATOM   5095 C  CG2 . VAL C 1 73  ? -29.177 2.808   28.618  1    38.72  ? 69  VAL C CG2 1 
ATOM   5096 N  N   . ILE C 1 74  ? -24.418 3.644   29.261  1    45.64  ? 70  ILE C N   1 
ATOM   5097 C  CA  . ILE C 1 74  ? -23.05  3.246   29.554  1    51.83  ? 70  ILE C CA  1 
ATOM   5098 C  C   . ILE C 1 74  ? -22.969 2.724   30.99   1    51.08  ? 70  ILE C C   1 
ATOM   5099 O  O   . ILE C 1 74  ? -23.249 3.447   31.931  1    53.71  ? 70  ILE C O   1 
ATOM   5100 C  CB  . ILE C 1 74  ? -22.045 4.386   29.263  1    55.69  ? 70  ILE C CB  1 
ATOM   5101 C  CG1 . ILE C 1 74  ? -21.749 4.525   27.774  1    56.84  ? 70  ILE C CG1 1 
ATOM   5102 C  CG2 . ILE C 1 74  ? -20.732 4.175   30.003  1    53.66  ? 70  ILE C CG2 1 
ATOM   5103 C  CD1 . ILE C 1 74  ? -22.544 5.627   27.099  1    58.06  ? 70  ILE C CD1 1 
ATOM   5104 N  N   . HIS C 1 75  ? -22.571 1.465   31.127  1    57.27  ? 71  HIS C N   1 
ATOM   5105 C  CA  . HIS C 1 75  ? -22.45  0.786   32.41   1    66.17  ? 71  HIS C CA  1 
ATOM   5106 C  C   . HIS C 1 75  ? -21.008 0.854   32.932  1    68.69  ? 71  HIS C C   1 
ATOM   5107 O  O   . HIS C 1 75  ? -20.026 0.856   32.177  1    63.48  ? 71  HIS C O   1 
ATOM   5108 C  CB  . HIS C 1 75  ? -22.823 -0.707  32.35   1    64.75  ? 71  HIS C CB  1 
ATOM   5109 C  CG  . HIS C 1 75  ? -24.186 -1.049  31.854  1    64.4   ? 71  HIS C CG  1 
ATOM   5110 N  ND1 . HIS C 1 75  ? -24.57  -0.738  30.558  1    71.81  ? 71  HIS C ND1 1 
ATOM   5111 C  CD2 . HIS C 1 75  ? -25.213 -1.701  32.418  1    57.77  ? 71  HIS C CD2 1 
ATOM   5112 C  CE1 . HIS C 1 75  ? -25.808 -1.164  30.349  1    70.84  ? 71  HIS C CE1 1 
ATOM   5113 N  NE2 . HIS C 1 75  ? -26.224 -1.74   31.471  1    71.43  ? 71  HIS C NE2 1 
ATOM   5114 N  N   . THR C 1 76  ? -20.907 0.926   34.262  1    71.76  ? 72  THR C N   1 
ATOM   5115 C  CA  . THR C 1 76  ? -19.675 0.699   34.994  1    68.47  ? 72  THR C CA  1 
ATOM   5116 C  C   . THR C 1 76  ? -20.059 -0.304  36.069  1    63.74  ? 72  THR C C   1 
ATOM   5117 O  O   . THR C 1 76  ? -21.193 -0.782  36.08   1    60.64  ? 72  THR C O   1 
ATOM   5118 C  CB  . THR C 1 76  ? -19.097 1.999   35.563  1    68.13  ? 72  THR C CB  1 
ATOM   5119 O  OG1 . THR C 1 76  ? -19.196 2.969   34.53   1    73.28  ? 72  THR C OG1 1 
ATOM   5120 C  CG2 . THR C 1 76  ? -17.626 1.872   35.931  1    80.28  ? 72  THR C CG2 1 
ATOM   5121 N  N   . GLU C 1 77  ? -19.118 -0.622  36.955  1    68.65  ? 73  GLU C N   1 
ATOM   5122 C  CA  . GLU C 1 77  ? -19.441 -1.505  38.059  1    72.14  ? 73  GLU C CA  1 
ATOM   5123 C  C   . GLU C 1 77  ? -20.183 -0.696  39.126  1    71.28  ? 73  GLU C C   1 
ATOM   5124 O  O   . GLU C 1 77  ? -20.931 -1.248  39.927  1    77.77  ? 73  GLU C O   1 
ATOM   5125 C  CB  . GLU C 1 77  ? -18.189 -2.259  38.518  1    74.88  ? 73  GLU C CB  1 
ATOM   5126 C  CG  . GLU C 1 77  ? -18.521 -3.421  39.451  1    87.38  ? 73  GLU C CG  1 
ATOM   5127 C  CD  . GLU C 1 77  ? -17.659 -3.433  40.725  1    106.12 ? 73  GLU C CD  1 
ATOM   5128 O  OE1 . GLU C 1 77  ? -18.252 -3.122  41.806  1    117.3  ? 73  GLU C OE1 1 
ATOM   5129 O  OE2 . GLU C 1 77  ? -16.418 -3.711  40.67   1    86.75  ? 73  GLU C OE2 1 
ATOM   5130 N  N   . ASN C 1 78  ? -19.986 0.628   39.117  1    69.1   ? 74  ASN C N   1 
ATOM   5131 C  CA  . ASN C 1 78  ? -20.383 1.517   40.198  1    65     ? 74  ASN C CA  1 
ATOM   5132 C  C   . ASN C 1 78  ? -21.38  2.58    39.743  1    63.48  ? 74  ASN C C   1 
ATOM   5133 O  O   . ASN C 1 78  ? -22.044 3.183   40.583  1    63.54  ? 74  ASN C O   1 
ATOM   5134 C  CB  . ASN C 1 78  ? -19.157 2.051   40.923  1    65.05  ? 74  ASN C CB  1 
ATOM   5135 C  CG  . ASN C 1 78  ? -18.565 0.996   41.844  1    75.03  ? 74  ASN C CG  1 
ATOM   5136 O  OD1 . ASN C 1 78  ? -17.512 0.439   41.522  1    77.89  ? 74  ASN C OD1 1 
ATOM   5137 N  ND2 . ASN C 1 78  ? -19.189 0.684   42.982  1    72.37  ? 74  ASN C ND2 1 
ATOM   5138 N  N   . LYS C 1 79  ? -21.468 2.832   38.429  1    62.31  ? 75  LYS C N   1 
ATOM   5139 C  CA  . LYS C 1 79  ? -22.312 3.918   37.953  1    59.99  ? 75  LYS C CA  1 
ATOM   5140 C  C   . LYS C 1 79  ? -23.045 3.5     36.69   1    53.93  ? 75  LYS C C   1 
ATOM   5141 O  O   . LYS C 1 79  ? -22.548 2.695   35.899  1    57.49  ? 75  LYS C O   1 
ATOM   5142 C  CB  . LYS C 1 79  ? -21.503 5.186   37.653  1    67.11  ? 75  LYS C CB  1 
ATOM   5143 C  CG  . LYS C 1 79  ? -20.913 5.926   38.848  1    91.05  ? 75  LYS C CG  1 
ATOM   5144 C  CD  . LYS C 1 79  ? -21.957 6.489   39.818  1    113.81 ? 75  LYS C CD  1 
ATOM   5145 C  CE  . LYS C 1 79  ? -21.437 6.919   41.187  1    111.85 ? 75  LYS C CE  1 
ATOM   5146 N  NZ  . LYS C 1 79  ? -21.339 8.377   41.357  1    106.81 ? 75  LYS C NZ  1 
ATOM   5147 N  N   . LEU C 1 80  ? -24.2   4.119   36.493  1    49.64  ? 76  LEU C N   1 
ATOM   5148 C  CA  . LEU C 1 80  ? -24.916 4.034   35.232  1    50.25  ? 76  LEU C CA  1 
ATOM   5149 C  C   . LEU C 1 80  ? -25.033 5.434   34.626  1    49.32  ? 76  LEU C C   1 
ATOM   5150 O  O   . LEU C 1 80  ? -25.439 6.377   35.31   1    49.58  ? 76  LEU C O   1 
ATOM   5151 C  CB  . LEU C 1 80  ? -26.285 3.444   35.559  1    50.31  ? 76  LEU C CB  1 
ATOM   5152 C  CG  . LEU C 1 80  ? -26.768 2.333   34.63   1    54.91  ? 76  LEU C CG  1 
ATOM   5153 C  CD1 . LEU C 1 80  ? -25.742 1.155   34.547  1    57.96  ? 76  LEU C CD1 1 
ATOM   5154 C  CD2 . LEU C 1 80  ? -28.128 1.875   35.151  1    53.37  ? 76  LEU C CD2 1 
ATOM   5155 N  N   . TYR C 1 81  ? -24.623 5.57    33.36   1    45.7   ? 77  TYR C N   1 
ATOM   5156 C  CA  . TYR C 1 81  ? -24.743 6.826   32.637  1    46.3   ? 77  TYR C CA  1 
ATOM   5157 C  C   . TYR C 1 81  ? -25.79  6.675   31.536  1    48.96  ? 77  TYR C C   1 
ATOM   5158 O  O   . TYR C 1 81  ? -25.635 5.843   30.639  1    52.78  ? 77  TYR C O   1 
ATOM   5159 C  CB  . TYR C 1 81  ? -23.386 7.205   32.046  1    50.22  ? 77  TYR C CB  1 
ATOM   5160 C  CG  . TYR C 1 81  ? -22.348 7.738   33.018  1    53.51  ? 77  TYR C CG  1 
ATOM   5161 C  CD1 . TYR C 1 81  ? -22.362 9.064   33.412  1    58.24  ? 77  TYR C CD1 1 
ATOM   5162 C  CD2 . TYR C 1 81  ? -21.348 6.926   33.523  1    59.41  ? 77  TYR C CD2 1 
ATOM   5163 C  CE1 . TYR C 1 81  ? -21.399 9.584   34.261  1    68.2   ? 77  TYR C CE1 1 
ATOM   5164 C  CE2 . TYR C 1 81  ? -20.375 7.426   34.377  1    72.38  ? 77  TYR C CE2 1 
ATOM   5165 C  CZ  . TYR C 1 81  ? -20.398 8.761   34.758  1    79.97  ? 77  TYR C CZ  1 
ATOM   5166 O  OH  . TYR C 1 81  ? -19.432 9.26    35.613  1    90.31  ? 77  TYR C OH  1 
ATOM   5167 N  N   . LEU C 1 82  ? -26.883 7.439   31.631  1    47.64  ? 78  LEU C N   1 
ATOM   5168 C  CA  . LEU C 1 82  ? -27.851 7.491   30.546  1    47.42  ? 78  LEU C CA  1 
ATOM   5169 C  C   . LEU C 1 82  ? -27.463 8.651   29.634  1    47.12  ? 78  LEU C C   1 
ATOM   5170 O  O   . LEU C 1 82  ? -27.175 9.75    30.109  1    43.86  ? 78  LEU C O   1 
ATOM   5171 C  CB  . LEU C 1 82  ? -29.294 7.688   31.027  1    54.08  ? 78  LEU C CB  1 
ATOM   5172 C  CG  . LEU C 1 82  ? -29.815 6.882   32.225  1    51.81  ? 78  LEU C CG  1 
ATOM   5173 C  CD1 . LEU C 1 82  ? -31.299 6.652   32.083  1    44.6   ? 78  LEU C CD1 1 
ATOM   5174 C  CD2 . LEU C 1 82  ? -29.097 5.588   32.429  1    58.12  ? 78  LEU C CD2 1 
ATOM   5175 N  N   . VAL C 1 83  ? -27.483 8.397   28.322  1    44.81  ? 79  VAL C N   1 
ATOM   5176 C  CA  . VAL C 1 83  ? -27.114 9.412   27.354  1    40.61  ? 79  VAL C CA  1 
ATOM   5177 C  C   . VAL C 1 83  ? -28.367 9.794   26.582  1    43.05  ? 79  VAL C C   1 
ATOM   5178 O  O   . VAL C 1 83  ? -28.899 8.994   25.803  1    44.62  ? 79  VAL C O   1 
ATOM   5179 C  CB  . VAL C 1 83  ? -26.018 8.9     26.407  1    40.52  ? 79  VAL C CB  1 
ATOM   5180 C  CG1 . VAL C 1 83  ? -25.609 9.998   25.424  1    35.99  ? 79  VAL C CG1 1 
ATOM   5181 C  CG2 . VAL C 1 83  ? -24.819 8.376   27.194  1    37.31  ? 79  VAL C CG2 1 
ATOM   5182 N  N   . PHE C 1 84  ? -28.855 11.008  26.843  1    41.3   ? 80  PHE C N   1 
ATOM   5183 C  CA  . PHE C 1 84  ? -30.088 11.497  26.236  1    41.87  ? 80  PHE C CA  1 
ATOM   5184 C  C   . PHE C 1 84  ? -29.752 12.505  25.154  1    40.95  ? 80  PHE C C   1 
ATOM   5185 O  O   . PHE C 1 84  ? -28.677 13.101  25.162  1    47.14  ? 80  PHE C O   1 
ATOM   5186 C  CB  . PHE C 1 84  ? -30.969 12.236  27.25   1    40.46  ? 80  PHE C CB  1 
ATOM   5187 C  CG  . PHE C 1 84  ? -31.683 11.316  28.216  1    39.31  ? 80  PHE C CG  1 
ATOM   5188 C  CD1 . PHE C 1 84  ? -32.907 10.776  27.877  1    40.27  ? 80  PHE C CD1 1 
ATOM   5189 C  CD2 . PHE C 1 84  ? -31.123 10.981  29.436  1    42.06  ? 80  PHE C CD2 1 
ATOM   5190 C  CE1 . PHE C 1 84  ? -33.568 9.934   28.746  1    40.06  ? 80  PHE C CE1 1 
ATOM   5191 C  CE2 . PHE C 1 84  ? -31.794 10.15   30.299  1    41.52  ? 80  PHE C CE2 1 
ATOM   5192 C  CZ  . PHE C 1 84  ? -33.016 9.644   29.957  1    40.83  ? 80  PHE C CZ  1 
ATOM   5193 N  N   . GLU C 1 85  ? -30.689 12.706  24.237  1    40.93  ? 81  GLU C N   1 
ATOM   5194 C  CA  . GLU C 1 85  ? -30.572 13.823  23.315  1    44.11  ? 81  GLU C CA  1 
ATOM   5195 C  C   . GLU C 1 85  ? -30.68  15.115  24.145  1    46.8   ? 81  GLU C C   1 
ATOM   5196 O  O   . GLU C 1 85  ? -31.39  15.151  25.151  1    52.08  ? 81  GLU C O   1 
ATOM   5197 C  CB  . GLU C 1 85  ? -31.636 13.671  22.222  1    39.12  ? 81  GLU C CB  1 
ATOM   5198 C  CG  . GLU C 1 85  ? -33.003 14.155  22.675  1    41.77  ? 81  GLU C CG  1 
ATOM   5199 C  CD  . GLU C 1 85  ? -34.1   14.184  21.634  1    43.9   ? 81  GLU C CD  1 
ATOM   5200 O  OE1 . GLU C 1 85  ? -34     14.957  20.658  1    48.61  ? 81  GLU C OE1 1 
ATOM   5201 O  OE2 . GLU C 1 85  ? -35.073 13.426  21.806  1    45.05  ? 81  GLU C OE2 1 
ATOM   5202 N  N   . PHE C 1 86  ? -29.983 16.183  23.729  1    45.66  ? 82  PHE C N   1 
ATOM   5203 C  CA  . PHE C 1 86  ? -30.008 17.453  24.444  1    44.56  ? 82  PHE C CA  1 
ATOM   5204 C  C   . PHE C 1 86  ? -31.087 18.365  23.874  1    46.97  ? 82  PHE C C   1 
ATOM   5205 O  O   . PHE C 1 86  ? -31.173 18.522  22.66   1    46.16  ? 82  PHE C O   1 
ATOM   5206 C  CB  . PHE C 1 86  ? -28.695 18.214  24.301  1    43.54  ? 82  PHE C CB  1 
ATOM   5207 C  CG  . PHE C 1 86  ? -28.724 19.571  24.973  1    45.7   ? 82  PHE C CG  1 
ATOM   5208 C  CD1 . PHE C 1 86  ? -28.612 19.67   26.372  1    45.89  ? 82  PHE C CD1 1 
ATOM   5209 C  CD2 . PHE C 1 86  ? -28.865 20.743  24.21   1    46.45  ? 82  PHE C CD2 1 
ATOM   5210 C  CE1 . PHE C 1 86  ? -28.644 20.926  27.002  1    50.65  ? 82  PHE C CE1 1 
ATOM   5211 C  CE2 . PHE C 1 86  ? -28.876 21.998  24.834  1    49.89  ? 82  PHE C CE2 1 
ATOM   5212 C  CZ  . PHE C 1 86  ? -28.774 22.093  26.23   1    52.45  ? 82  PHE C CZ  1 
ATOM   5213 N  N   . LEU C 1 87  ? -31.899 18.958  24.759  1    49.93  ? 83  LEU C N   1 
ATOM   5214 C  CA  . LEU C 1 87  ? -32.891 19.944  24.357  1    49.36  ? 83  LEU C CA  1 
ATOM   5215 C  C   . LEU C 1 87  ? -32.63  21.231  25.145  1    49.44  ? 83  LEU C C   1 
ATOM   5216 O  O   . LEU C 1 87  ? -32.333 21.192  26.335  1    48.6   ? 83  LEU C O   1 
ATOM   5217 C  CB  . LEU C 1 87  ? -34.291 19.347  24.505  1    48.9   ? 83  LEU C CB  1 
ATOM   5218 C  CG  . LEU C 1 87  ? -34.711 18.321  23.439  1    48.95  ? 83  LEU C CG  1 
ATOM   5219 C  CD1 . LEU C 1 87  ? -34.915 16.972  24.052  1    52.38  ? 83  LEU C CD1 1 
ATOM   5220 C  CD2 . LEU C 1 87  ? -35.996 18.736  22.769  1    59.02  ? 83  LEU C CD2 1 
ATOM   5221 N  N   A HIS C 1 88  ? -32.664 22.354  24.415  0.5  54.28  ? 84  HIS C N   1 
ATOM   5222 N  N   B HIS C 1 88  ? -32.702 22.353  24.438  0.5  56.75  ? 84  HIS C N   1 
ATOM   5223 C  CA  A HIS C 1 88  ? -32.417 23.728  24.859  0.5  59.48  ? 84  HIS C CA  1 
ATOM   5224 C  CA  B HIS C 1 88  ? -32.345 23.687  24.906  0.5  64.1   ? 84  HIS C CA  1 
ATOM   5225 C  C   A HIS C 1 88  ? -32.866 24.022  26.299  0.5  59.81  ? 84  HIS C C   1 
ATOM   5226 C  C   B HIS C 1 88  ? -32.86  24.029  26.316  0.5  62.44  ? 84  HIS C C   1 
ATOM   5227 O  O   A HIS C 1 88  ? -32.035 24.395  27.132  0.5  60.76  ? 84  HIS C O   1 
ATOM   5228 O  O   B HIS C 1 88  ? -32.047 24.401  27.167  0.5  62.87  ? 84  HIS C O   1 
ATOM   5229 C  CB  A HIS C 1 88  ? -33.094 24.715  23.899  0.5  58.84  ? 84  HIS C CB  1 
ATOM   5230 C  CB  B HIS C 1 88  ? -32.63  24.663  23.765  0.5  68.96  ? 84  HIS C CB  1 
ATOM   5231 C  CG  A HIS C 1 88  ? -33.21  26.093  24.432  0.5  60.42  ? 84  HIS C CG  1 
ATOM   5232 C  CG  B HIS C 1 88  ? -32.032 24.182  22.472  0.5  76.28  ? 84  HIS C CG  1 
ATOM   5233 N  ND1 A HIS C 1 88  ? -34.379 26.817  24.473  0.5  60.84  ? 84  HIS C ND1 1 
ATOM   5234 N  ND1 B HIS C 1 88  ? -30.746 24.48   22.065  0.5  77.94  ? 84  HIS C ND1 1 
ATOM   5235 C  CD2 A HIS C 1 88  ? -32.258 26.88   24.921  0.5  62.65  ? 84  HIS C CD2 1 
ATOM   5236 C  CD2 B HIS C 1 88  ? -32.567 23.438  21.484  0.5  72.9   ? 84  HIS C CD2 1 
ATOM   5237 C  CE1 A HIS C 1 88  ? -34.129 28      25.014  0.5  65.9   ? 84  HIS C CE1 1 
ATOM   5238 C  CE1 B HIS C 1 88  ? -30.518 23.933  20.882  0.5  74.14  ? 84  HIS C CE1 1 
ATOM   5239 N  NE2 A HIS C 1 88  ? -32.846 28.069  25.274  0.5  66.68  ? 84  HIS C NE2 1 
ATOM   5240 N  NE2 B HIS C 1 88  ? -31.626 23.335  20.493  0.5  78.22  ? 84  HIS C NE2 1 
ATOM   5241 N  N   . GLN C 1 89  ? -34.18  23.925  26.566  1    56.99  ? 85  GLN C N   1 
ATOM   5242 C  CA  . GLN C 1 89  ? -34.743 24.159  27.902  1    56.79  ? 85  GLN C CA  1 
ATOM   5243 C  C   . GLN C 1 89  ? -36.048 23.383  28.145  1    51.55  ? 85  GLN C C   1 
ATOM   5244 O  O   . GLN C 1 89  ? -36.537 22.7    27.256  1    49.25  ? 85  GLN C O   1 
ATOM   5245 C  CB  . GLN C 1 89  ? -34.925 25.648  28.191  1    57.58  ? 85  GLN C CB  1 
ATOM   5246 C  CG  . GLN C 1 89  ? -36.043 26.308  27.397  1    62.89  ? 85  GLN C CG  1 
ATOM   5247 C  CD  . GLN C 1 89  ? -36.093 27.796  27.684  1    67.59  ? 85  GLN C CD  1 
ATOM   5248 O  OE1 . GLN C 1 89  ? -35.436 28.285  28.605  1    58.21  ? 85  GLN C OE1 1 
ATOM   5249 N  NE2 . GLN C 1 89  ? -36.857 28.536  26.889  1    77.15  ? 85  GLN C NE2 1 
ATOM   5250 N  N   . ASP C 1 90  ? -36.634 23.53   29.349  1    48.07  ? 86  ASP C N   1 
ATOM   5251 C  CA  . ASP C 1 90  ? -37.922 22.952  29.723  1    44.4   ? 86  ASP C CA  1 
ATOM   5252 C  C   . ASP C 1 90  ? -39.047 23.991  29.582  1    46.05  ? 86  ASP C C   1 
ATOM   5253 O  O   . ASP C 1 90  ? -38.785 25.193  29.503  1    46.76  ? 86  ASP C O   1 
ATOM   5254 C  CB  . ASP C 1 90  ? -37.87  22.39   31.14   1    43.65  ? 86  ASP C CB  1 
ATOM   5255 C  CG  . ASP C 1 90  ? -37.788 23.408  32.255  1    46.58  ? 86  ASP C CG  1 
ATOM   5256 O  OD1 . ASP C 1 90  ? -38.768 24.149  32.46   1    49.64  ? 86  ASP C OD1 1 
ATOM   5257 O  OD2 . ASP C 1 90  ? -36.728 23.45   32.881  1    57.29  ? 86  ASP C OD2 1 
ATOM   5258 N  N   . LEU C 1 91  ? -40.302 23.522  29.58   1    41.72  ? 87  LEU C N   1 
ATOM   5259 C  CA  . LEU C 1 91  ? -41.453 24.368  29.328  1    43.72  ? 87  LEU C CA  1 
ATOM   5260 C  C   . LEU C 1 91  ? -41.612 25.381  30.458  1    46.38  ? 87  LEU C C   1 
ATOM   5261 O  O   . LEU C 1 91  ? -41.965 26.535  30.202  1    49.1   ? 87  LEU C O   1 
ATOM   5262 C  CB  . LEU C 1 91  ? -42.697 23.491  29.203  1    42.99  ? 87  LEU C CB  1 
ATOM   5263 C  CG  . LEU C 1 91  ? -43.969 24.19   28.706  1    43.15  ? 87  LEU C CG  1 
ATOM   5264 C  CD1 . LEU C 1 91  ? -43.721 24.798  27.347  1    42.93  ? 87  LEU C CD1 1 
ATOM   5265 C  CD2 . LEU C 1 91  ? -45.134 23.192  28.654  1    40.11  ? 87  LEU C CD2 1 
ATOM   5266 N  N   . LYS C 1 92  ? -41.376 24.941  31.697  1    43.9   ? 88  LYS C N   1 
ATOM   5267 C  CA  . LYS C 1 92  ? -41.457 25.828  32.849  1    47.46  ? 88  LYS C CA  1 
ATOM   5268 C  C   . LYS C 1 92  ? -40.523 27.026  32.67   1    52.12  ? 88  LYS C C   1 
ATOM   5269 O  O   . LYS C 1 92  ? -40.939 28.172  32.839  1    55.2   ? 88  LYS C O   1 
ATOM   5270 C  CB  . LYS C 1 92  ? -41.235 25.035  34.131  1    44.47  ? 88  LYS C CB  1 
ATOM   5271 C  CG  . LYS C 1 92  ? -40.962 25.799  35.39   1    55.81  ? 88  LYS C CG  1 
ATOM   5272 C  CD  . LYS C 1 92  ? -41.944 26.912  35.738  1    72.46  ? 88  LYS C CD  1 
ATOM   5273 C  CE  . LYS C 1 92  ? -43.389 26.513  35.691  1    85.92  ? 88  LYS C CE  1 
ATOM   5274 N  NZ  . LYS C 1 92  ? -44.245 27.602  36.188  1    85     ? 88  LYS C NZ  1 
ATOM   5275 N  N   . LYS C 1 93  ? -39.276 26.762  32.263  1    54.23  ? 89  LYS C N   1 
ATOM   5276 C  CA  . LYS C 1 93  ? -38.311 27.824  32.045  1    54.47  ? 89  LYS C CA  1 
ATOM   5277 C  C   . LYS C 1 93  ? -38.774 28.76   30.927  1    52.25  ? 89  LYS C C   1 
ATOM   5278 O  O   . LYS C 1 93  ? -38.646 29.986  31.066  1    50.09  ? 89  LYS C O   1 
ATOM   5279 C  CB  . LYS C 1 93  ? -36.954 27.232  31.653  1    61.39  ? 89  LYS C CB  1 
ATOM   5280 C  CG  . LYS C 1 93  ? -36.048 26.841  32.816  1    75.74  ? 89  LYS C CG  1 
ATOM   5281 C  CD  . LYS C 1 93  ? -34.597 27.033  32.361  1    99.61  ? 89  LYS C CD  1 
ATOM   5282 C  CE  . LYS C 1 93  ? -33.518 27.038  33.391  1    107.25 ? 89  LYS C CE  1 
ATOM   5283 N  NZ  . LYS C 1 93  ? -33.478 25.684  33.94   1    115.47 ? 89  LYS C NZ  1 
ATOM   5284 N  N   . PHE C 1 94  ? -39.271 28.166  29.822  1    46.43  ? 90  PHE C N   1 
ATOM   5285 C  CA  . PHE C 1 94  ? -39.756 28.921  28.673  1    51.18  ? 90  PHE C CA  1 
ATOM   5286 C  C   . PHE C 1 94  ? -40.892 29.883  29.065  1    57.29  ? 90  PHE C C   1 
ATOM   5287 O  O   . PHE C 1 94  ? -40.835 31.086  28.749  1    56.29  ? 90  PHE C O   1 
ATOM   5288 C  CB  . PHE C 1 94  ? -40.161 27.983  27.538  1    46.79  ? 90  PHE C CB  1 
ATOM   5289 C  CG  . PHE C 1 94  ? -40.706 28.692  26.316  1    44.95  ? 90  PHE C CG  1 
ATOM   5290 C  CD1 . PHE C 1 94  ? -39.928 29.633  25.639  1    46.41  ? 90  PHE C CD1 1 
ATOM   5291 C  CD2 . PHE C 1 94  ? -42.015 28.447  25.893  1    44.08  ? 90  PHE C CD2 1 
ATOM   5292 C  CE1 . PHE C 1 94  ? -40.454 30.294  24.529  1    48.8   ? 90  PHE C CE1 1 
ATOM   5293 C  CE2 . PHE C 1 94  ? -42.541 29.104  24.78   1    45.85  ? 90  PHE C CE2 1 
ATOM   5294 C  CZ  . PHE C 1 94  ? -41.753 30.021  24.1    1    47.83  ? 90  PHE C CZ  1 
ATOM   5295 N  N   . MET C 1 95  ? -41.914 29.338  29.751  1    52.93  ? 91  MET C N   1 
ATOM   5296 C  CA  . MET C 1 95  ? -43.057 30.094  30.241  1    51.44  ? 91  MET C CA  1 
ATOM   5297 C  C   . MET C 1 95  ? -42.593 31.259  31.112  1    51.41  ? 91  MET C C   1 
ATOM   5298 O  O   . MET C 1 95  ? -43     32.404  30.887  1    54.9   ? 91  MET C O   1 
ATOM   5299 C  CB  . MET C 1 95  ? -44.007 29.185  31.019  1    50.21  ? 91  MET C CB  1 
ATOM   5300 C  CG  . MET C 1 95  ? -44.809 28.257  30.135  1    52.34  ? 91  MET C CG  1 
ATOM   5301 S  SD  . MET C 1 95  ? -46.087 27.292  30.98   1    65.37  ? 91  MET C SD  1 
ATOM   5302 C  CE  . MET C 1 95  ? -45.212 26.155  32.068  1    47.65  ? 91  MET C CE  1 
ATOM   5303 N  N   . ASP C 1 96  ? -41.729 30.961  32.089  1    48.77  ? 92  ASP C N   1 
ATOM   5304 C  CA  . ASP C 1 96  ? -41.178 31.968  32.988  1    51.88  ? 92  ASP C CA  1 
ATOM   5305 C  C   . ASP C 1 96  ? -40.482 33.078  32.202  1    52.54  ? 92  ASP C C   1 
ATOM   5306 O  O   . ASP C 1 96  ? -40.572 34.256  32.551  1    53.5   ? 92  ASP C O   1 
ATOM   5307 C  CB  . ASP C 1 96  ? -40.246 31.372  34.029  1    51.84  ? 92  ASP C CB  1 
ATOM   5308 C  CG  . ASP C 1 96  ? -40.922 30.563  35.125  1    56.41  ? 92  ASP C CG  1 
ATOM   5309 O  OD1 . ASP C 1 96  ? -42.17  30.56   35.157  1    60.26  ? 92  ASP C OD1 1 
ATOM   5310 O  OD2 . ASP C 1 96  ? -40.201 29.89   35.898  1    61.62  ? 92  ASP C OD2 1 
ATOM   5311 N  N   . ALA C 1 97  ? -39.767 32.701  31.142  1    51.23  ? 93  ALA C N   1 
ATOM   5312 C  CA  . ALA C 1 97  ? -39.044 33.679  30.349  1    51.84  ? 93  ALA C CA  1 
ATOM   5313 C  C   . ALA C 1 97  ? -40.029 34.494  29.516  1    51.57  ? 93  ALA C C   1 
ATOM   5314 O  O   . ALA C 1 97  ? -39.764 35.648  29.212  1    52.75  ? 93  ALA C O   1 
ATOM   5315 C  CB  . ALA C 1 97  ? -38.033 32.976  29.487  1    50.18  ? 93  ALA C CB  1 
ATOM   5316 N  N   . SER C 1 98  ? -41.146 33.863  29.146  1    53.28  ? 94  SER C N   1 
ATOM   5317 C  CA  . SER C 1 98  ? -42.197 34.481  28.358  1    60.84  ? 94  SER C CA  1 
ATOM   5318 C  C   . SER C 1 98  ? -43.251 35.149  29.243  1    72.14  ? 94  SER C C   1 
ATOM   5319 O  O   . SER C 1 98  ? -44.333 35.445  28.745  1    74.88  ? 94  SER C O   1 
ATOM   5320 C  CB  . SER C 1 98  ? -42.881 33.465  27.483  1    54.53  ? 94  SER C CB  1 
ATOM   5321 O  OG  . SER C 1 98  ? -41.978 32.909  26.553  1    55.72  ? 94  SER C OG  1 
ATOM   5322 N  N   . ALA C 1 99  ? -42.948 35.371  30.532  1    79.79  ? 95  ALA C N   1 
ATOM   5323 C  CA  . ALA C 1 99  ? -43.919 35.849  31.509  1    83.26  ? 95  ALA C CA  1 
ATOM   5324 C  C   . ALA C 1 99  ? -44.498 37.218  31.123  1    84.21  ? 95  ALA C C   1 
ATOM   5325 O  O   . ALA C 1 99  ? -45.7   37.433  31.291  1    82.13  ? 95  ALA C O   1 
ATOM   5326 C  CB  . ALA C 1 99  ? -43.282 35.895  32.873  1    87.81  ? 95  ALA C CB  1 
ATOM   5327 N  N   . LEU C 1 100 ? -43.661 38.098  30.561  1    74.11  ? 96  LEU C N   1 
ATOM   5328 C  CA  . LEU C 1 100 ? -44.066 39.433  30.163  1    81.79  ? 96  LEU C CA  1 
ATOM   5329 C  C   . LEU C 1 100 ? -44.525 39.485  28.705  1    91.62  ? 96  LEU C C   1 
ATOM   5330 O  O   . LEU C 1 100 ? -45.495 40.174  28.415  1    112.21 ? 96  LEU C O   1 
ATOM   5331 C  CB  . LEU C 1 100 ? -42.925 40.43   30.355  1    88.49  ? 96  LEU C CB  1 
ATOM   5332 C  CG  . LEU C 1 100 ? -42.29  40.525  31.745  1    91.64  ? 96  LEU C CG  1 
ATOM   5333 C  CD1 . LEU C 1 100 ? -41.493 41.824  31.871  1    89.28  ? 96  LEU C CD1 1 
ATOM   5334 C  CD2 . LEU C 1 100 ? -43.326 40.426  32.847  1    95.83  ? 96  LEU C CD2 1 
ATOM   5335 N  N   . THR C 1 101 ? -43.775 38.856  27.778  1    82.54  ? 97  THR C N   1 
ATOM   5336 C  CA  . THR C 1 101 ? -44.092 38.874  26.347  1    73.93  ? 97  THR C CA  1 
ATOM   5337 C  C   . THR C 1 101 ? -45.301 37.985  26.025  1    67.21  ? 97  THR C C   1 
ATOM   5338 O  O   . THR C 1 101 ? -45.948 38.148  25.009  1    64.93  ? 97  THR C O   1 
ATOM   5339 C  CB  . THR C 1 101 ? -42.91  38.473  25.455  1    72.44  ? 97  THR C CB  1 
ATOM   5340 O  OG1 . THR C 1 101 ? -42.62  37.081  25.62   1    66.01  ? 97  THR C OG1 1 
ATOM   5341 C  CG2 . THR C 1 101 ? -41.685 39.342  25.687  1    75.47  ? 97  THR C CG2 1 
ATOM   5342 N  N   . GLY C 1 102 ? -45.606 37.009  26.871  1    66.58  ? 98  GLY C N   1 
ATOM   5343 C  CA  . GLY C 1 102 ? -46.612 36.021  26.514  1    64.4   ? 98  GLY C CA  1 
ATOM   5344 C  C   . GLY C 1 102 ? -46.102 35.1    25.409  1    62.48  ? 98  GLY C C   1 
ATOM   5345 O  O   . GLY C 1 102 ? -45.05  35.345  24.824  1    58.93  ? 98  GLY C O   1 
ATOM   5346 N  N   . ILE C 1 103 ? -46.845 34.008  25.187  1    64.22  ? 99  ILE C N   1 
ATOM   5347 C  CA  . ILE C 1 103 ? -46.541 32.974  24.212  1    62.71  ? 99  ILE C CA  1 
ATOM   5348 C  C   . ILE C 1 103 ? -47.582 33.07   23.096  1    64.21  ? 99  ILE C C   1 
ATOM   5349 O  O   . ILE C 1 103 ? -48.782 32.995  23.358  1    65.43  ? 99  ILE C O   1 
ATOM   5350 C  CB  . ILE C 1 103 ? -46.619 31.591  24.887  1    61.82  ? 99  ILE C CB  1 
ATOM   5351 C  CG1 . ILE C 1 103 ? -45.813 31.548  26.184  1    61.64  ? 99  ILE C CG1 1 
ATOM   5352 C  CG2 . ILE C 1 103 ? -46.246 30.469  23.908  1    57.92  ? 99  ILE C CG2 1 
ATOM   5353 C  CD1 . ILE C 1 103 ? -45.839 30.194  26.877  1    61.58  ? 99  ILE C CD1 1 
ATOM   5354 N  N   . PRO C 1 104 ? -47.189 33.21   21.81   1    62.23  ? 100 PRO C N   1 
ATOM   5355 C  CA  . PRO C 1 104 ? -48.187 33.277  20.745  1    61.29  ? 100 PRO C CA  1 
ATOM   5356 C  C   . PRO C 1 104 ? -49.08  32.037  20.775  1    59.83  ? 100 PRO C C   1 
ATOM   5357 O  O   . PRO C 1 104 ? -48.635 30.943  21.11   1    55.52  ? 100 PRO C O   1 
ATOM   5358 C  CB  . PRO C 1 104 ? -47.338 33.416  19.468  1    60.78  ? 100 PRO C CB  1 
ATOM   5359 C  CG  . PRO C 1 104 ? -46.044 34.011  19.968  1    59.94  ? 100 PRO C CG  1 
ATOM   5360 C  CD  . PRO C 1 104 ? -45.809 33.328  21.318  1    60.94  ? 100 PRO C CD  1 
ATOM   5361 N  N   . LEU C 1 105 ? -50.354 32.246  20.446  1    63.85  ? 101 LEU C N   1 
ATOM   5362 C  CA  . LEU C 1 105 ? -51.363 31.196  20.369  1    72.78  ? 101 LEU C CA  1 
ATOM   5363 C  C   . LEU C 1 105 ? -50.932 30.035  19.454  1    64.99  ? 101 LEU C C   1 
ATOM   5364 O  O   . LEU C 1 105 ? -50.987 28.88   19.88   1    62.05  ? 101 LEU C O   1 
ATOM   5365 C  CB  . LEU C 1 105 ? -52.715 31.812  19.984  1    78.94  ? 101 LEU C CB  1 
ATOM   5366 C  CG  . LEU C 1 105 ? -53.984 31.032  20.36   1    83.41  ? 101 LEU C CG  1 
ATOM   5367 C  CD1 . LEU C 1 105 ? -54.324 29.869  19.412  1    84.55  ? 101 LEU C CD1 1 
ATOM   5368 C  CD2 . LEU C 1 105 ? -53.874 30.552  21.796  1    81.99  ? 101 LEU C CD2 1 
ATOM   5369 N  N   . PRO C 1 106 ? -50.458 30.272  18.207  1    61.72  ? 102 PRO C N   1 
ATOM   5370 C  CA  . PRO C 1 106 ? -50.039 29.174  17.325  1    61.07  ? 102 PRO C CA  1 
ATOM   5371 C  C   . PRO C 1 106 ? -49.023 28.225  17.956  1    57.41  ? 102 PRO C C   1 
ATOM   5372 O  O   . PRO C 1 106 ? -49.103 27.016  17.74   1    52.26  ? 102 PRO C O   1 
ATOM   5373 C  CB  . PRO C 1 106 ? -49.495 29.838  16.033  1    59.61  ? 102 PRO C CB  1 
ATOM   5374 C  CG  . PRO C 1 106 ? -50.066 31.247  16.074  1    60.12  ? 102 PRO C CG  1 
ATOM   5375 C  CD  . PRO C 1 106 ? -50.265 31.588  17.564  1    62.63  ? 102 PRO C CD  1 
ATOM   5376 N  N   . LEU C 1 107 ? -48.098 28.789  18.751  1    56.43  ? 103 LEU C N   1 
ATOM   5377 C  CA  . LEU C 1 107 ? -47.051 28.012  19.41   1    55.52  ? 103 LEU C CA  1 
ATOM   5378 C  C   . LEU C 1 107 ? -47.641 27.152  20.532  1    51.64  ? 103 LEU C C   1 
ATOM   5379 O  O   . LEU C 1 107 ? -47.237 26.002  20.721  1    46.78  ? 103 LEU C O   1 
ATOM   5380 C  CB  . LEU C 1 107 ? -45.926 28.912  19.938  1    53.2   ? 103 LEU C CB  1 
ATOM   5381 C  CG  . LEU C 1 107 ? -44.678 28.176  20.445  1    49.79  ? 103 LEU C CG  1 
ATOM   5382 C  CD1 . LEU C 1 107 ? -43.968 27.415  19.346  1    46.79  ? 103 LEU C CD1 1 
ATOM   5383 C  CD2 . LEU C 1 107 ? -43.713 29.131  21.12   1    51.36  ? 103 LEU C CD2 1 
ATOM   5384 N  N   . ILE C 1 108 ? -48.589 27.736  21.279  1    50.44  ? 104 ILE C N   1 
ATOM   5385 C  CA  . ILE C 1 108 ? -49.318 27      22.297  1    52.34  ? 104 ILE C CA  1 
ATOM   5386 C  C   . ILE C 1 108 ? -49.984 25.778  21.654  1    55.07  ? 104 ILE C C   1 
ATOM   5387 O  O   . ILE C 1 108 ? -49.836 24.631  22.112  1    55.22  ? 104 ILE C O   1 
ATOM   5388 C  CB  . ILE C 1 108 ? -50.317 27.912  23.034  1    49.23  ? 104 ILE C CB  1 
ATOM   5389 C  CG1 . ILE C 1 108 ? -49.573 29.017  23.807  1    49.25  ? 104 ILE C CG1 1 
ATOM   5390 C  CG2 . ILE C 1 108 ? -51.223 27.077  23.944  1    44.71  ? 104 ILE C CG2 1 
ATOM   5391 C  CD1 . ILE C 1 108 ? -50.491 30.012  24.509  1    49.45  ? 104 ILE C CD1 1 
ATOM   5392 N  N   . LYS C 1 109 ? -50.73  26.043  20.581  1    54.45  ? 105 LYS C N   1 
ATOM   5393 C  CA  . LYS C 1 109 ? -51.506 25.013  19.912  1    54.2   ? 105 LYS C CA  1 
ATOM   5394 C  C   . LYS C 1 109 ? -50.578 23.932  19.362  1    51.64  ? 105 LYS C C   1 
ATOM   5395 O  O   . LYS C 1 109 ? -50.916 22.754  19.418  1    50.34  ? 105 LYS C O   1 
ATOM   5396 C  CB  . LYS C 1 109 ? -52.328 25.686  18.808  1    55.57  ? 105 LYS C CB  1 
ATOM   5397 C  CG  . LYS C 1 109 ? -53.166 24.773  17.931  1    57.54  ? 105 LYS C CG  1 
ATOM   5398 C  CD  . LYS C 1 109 ? -53.915 25.589  16.878  1    58.05  ? 105 LYS C CD  1 
ATOM   5399 C  CE  . LYS C 1 109 ? -54.773 26.673  17.446  1    56.77  ? 105 LYS C CE  1 
ATOM   5400 N  NZ  . LYS C 1 109 ? -55.814 27.036  16.494  1    60.7   ? 105 LYS C NZ  1 
ATOM   5401 N  N   . SER C 1 110 ? -49.423 24.354  18.822  1    49.79  ? 106 SER C N   1 
ATOM   5402 C  CA  . SER C 1 110 ? -48.444 23.431  18.289  1    51.57  ? 106 SER C CA  1 
ATOM   5403 C  C   . SER C 1 110 ? -47.944 22.513  19.402  1    49.21  ? 106 SER C C   1 
ATOM   5404 O  O   . SER C 1 110 ? -47.913 21.286  19.244  1    47.98  ? 106 SER C O   1 
ATOM   5405 C  CB  . SER C 1 110 ? -47.298 24.15   17.622  1    51.23  ? 106 SER C CB  1 
ATOM   5406 O  OG  . SER C 1 110 ? -46.364 23.205  17.087  1    50.19  ? 106 SER C OG  1 
ATOM   5407 N  N   . TYR C 1 111 ? -47.565 23.14   20.52   1    46.26  ? 107 TYR C N   1 
ATOM   5408 C  CA  . TYR C 1 111 ? -46.977 22.426  21.636  1    47.04  ? 107 TYR C CA  1 
ATOM   5409 C  C   . TYR C 1 111 ? -47.981 21.411  22.187  1    48.73  ? 107 TYR C C   1 
ATOM   5410 O  O   . TYR C 1 111 ? -47.627 20.244  22.426  1    51.53  ? 107 TYR C O   1 
ATOM   5411 C  CB  . TYR C 1 111 ? -46.479 23.399  22.705  1    44.74  ? 107 TYR C CB  1 
ATOM   5412 C  CG  . TYR C 1 111 ? -45.124 24.04   22.483  1    44.81  ? 107 TYR C CG  1 
ATOM   5413 C  CD1 . TYR C 1 111 ? -44.261 23.649  21.46   1    47.47  ? 107 TYR C CD1 1 
ATOM   5414 C  CD2 . TYR C 1 111 ? -44.698 25.034  23.345  1    48.03  ? 107 TYR C CD2 1 
ATOM   5415 C  CE1 . TYR C 1 111 ? -43.009 24.231  21.313  1    51.75  ? 107 TYR C CE1 1 
ATOM   5416 C  CE2 . TYR C 1 111 ? -43.464 25.642  23.192  1    52.84  ? 107 TYR C CE2 1 
ATOM   5417 C  CZ  . TYR C 1 111 ? -42.608 25.241  22.182  1    53.74  ? 107 TYR C CZ  1 
ATOM   5418 O  OH  . TYR C 1 111 ? -41.386 25.861  22.115  1    49.95  ? 107 TYR C OH  1 
ATOM   5419 N  N   . LEU C 1 112 ? -49.238 21.848  22.359  1    47.86  ? 108 LEU C N   1 
ATOM   5420 C  CA  . LEU C 1 112 ? -50.267 20.96   22.877  1    47.62  ? 108 LEU C CA  1 
ATOM   5421 C  C   . LEU C 1 112 ? -50.471 19.785  21.931  1    47.16  ? 108 LEU C C   1 
ATOM   5422 O  O   . LEU C 1 112 ? -50.58  18.646  22.389  1    46.88  ? 108 LEU C O   1 
ATOM   5423 C  CB  . LEU C 1 112 ? -51.583 21.687  23.094  1    48.21  ? 108 LEU C CB  1 
ATOM   5424 C  CG  . LEU C 1 112 ? -52.638 20.856  23.827  1    49     ? 108 LEU C CG  1 
ATOM   5425 C  CD1 . LEU C 1 112 ? -52.169 20.547  25.247  1    47.12  ? 108 LEU C CD1 1 
ATOM   5426 C  CD2 . LEU C 1 112 ? -53.971 21.577  23.837  1    49.37  ? 108 LEU C CD2 1 
ATOM   5427 N  N   . PHE C 1 113 ? -50.513 20.083  20.627  1    47.26  ? 109 PHE C N   1 
ATOM   5428 C  CA  . PHE C 1 113 ? -50.691 19.063  19.608  1    50.74  ? 109 PHE C CA  1 
ATOM   5429 C  C   . PHE C 1 113 ? -49.613 17.998  19.778  1    50.19  ? 109 PHE C C   1 
ATOM   5430 O  O   . PHE C 1 113 ? -49.905 16.796  19.827  1    54.05  ? 109 PHE C O   1 
ATOM   5431 C  CB  . PHE C 1 113 ? -50.648 19.687  18.209  1    52.97  ? 109 PHE C CB  1 
ATOM   5432 C  CG  . PHE C 1 113 ? -51.133 18.823  17.053  1    54.18  ? 109 PHE C CG  1 
ATOM   5433 C  CD1 . PHE C 1 113 ? -52.431 18.306  17.04   1    54.69  ? 109 PHE C CD1 1 
ATOM   5434 C  CD2 . PHE C 1 113 ? -50.283 18.527  15.976  1    57.08  ? 109 PHE C CD2 1 
ATOM   5435 C  CE1 . PHE C 1 113 ? -52.871 17.521  15.975  1    56.93  ? 109 PHE C CE1 1 
ATOM   5436 C  CE2 . PHE C 1 113 ? -50.724 17.745  14.902  1    56     ? 109 PHE C CE2 1 
ATOM   5437 C  CZ  . PHE C 1 113 ? -52.008 17.227  14.907  1    55.58  ? 109 PHE C CZ  1 
ATOM   5438 N  N   . GLN C 1 114 ? -48.364 18.455  19.879  1    50.17  ? 110 GLN C N   1 
ATOM   5439 C  CA  . GLN C 1 114 ? -47.212 17.557  19.911  1    53.07  ? 110 GLN C CA  1 
ATOM   5440 C  C   . GLN C 1 114 ? -47.216 16.731  21.198  1    49.37  ? 110 GLN C C   1 
ATOM   5441 O  O   . GLN C 1 114 ? -46.869 15.554  21.168  1    48.25  ? 110 GLN C O   1 
ATOM   5442 C  CB  . GLN C 1 114 ? -45.919 18.352  19.757  1    51.15  ? 110 GLN C CB  1 
ATOM   5443 C  CG  . GLN C 1 114 ? -45.653 18.898  18.358  1    46.12  ? 110 GLN C CG  1 
ATOM   5444 C  CD  . GLN C 1 114 ? -44.365 19.69   18.356  1    49.92  ? 110 GLN C CD  1 
ATOM   5445 O  OE1 . GLN C 1 114 ? -43.262 19.13   18.448  1    51.11  ? 110 GLN C OE1 1 
ATOM   5446 N  NE2 . GLN C 1 114 ? -44.499 21.008  18.328  1    46.81  ? 110 GLN C NE2 1 
ATOM   5447 N  N   . LEU C 1 115 ? -47.631 17.363  22.308  1    48.19  ? 111 LEU C N   1 
ATOM   5448 C  CA  . LEU C 1 115 ? -47.678 16.712  23.613  1    47.27  ? 111 LEU C CA  1 
ATOM   5449 C  C   . LEU C 1 115 ? -48.706 15.588  23.567  1    48.28  ? 111 LEU C C   1 
ATOM   5450 O  O   . LEU C 1 115 ? -48.524 14.564  24.224  1    44.27  ? 111 LEU C O   1 
ATOM   5451 C  CB  . LEU C 1 115 ? -48.018 17.696  24.727  1    40.63  ? 111 LEU C CB  1 
ATOM   5452 C  CG  . LEU C 1 115 ? -46.933 18.691  25.098  1    39.84  ? 111 LEU C CG  1 
ATOM   5453 C  CD1 . LEU C 1 115 ? -47.411 19.624  26.173  1    38.34  ? 111 LEU C CD1 1 
ATOM   5454 C  CD2 . LEU C 1 115 ? -45.737 17.944  25.593  1    40.67  ? 111 LEU C CD2 1 
ATOM   5455 N  N   . LEU C 1 116 ? -49.779 15.808  22.792  1    45.33  ? 112 LEU C N   1 
ATOM   5456 C  CA  . LEU C 1 116 ? -50.86  14.851  22.719  1    47.81  ? 112 LEU C CA  1 
ATOM   5457 C  C   . LEU C 1 116 ? -50.453 13.676  21.833  1    54.73  ? 112 LEU C C   1 
ATOM   5458 O  O   . LEU C 1 116 ? -50.856 12.546  22.123  1    55.72  ? 112 LEU C O   1 
ATOM   5459 C  CB  . LEU C 1 116 ? -52.099 15.567  22.198  1    49.31  ? 112 LEU C CB  1 
ATOM   5460 C  CG  . LEU C 1 116 ? -52.843 16.397  23.241  1    49.54  ? 112 LEU C CG  1 
ATOM   5461 C  CD1 . LEU C 1 116 ? -53.716 17.438  22.54   1    49.68  ? 112 LEU C CD1 1 
ATOM   5462 C  CD2 . LEU C 1 116 ? -53.671 15.474  24.129  1    43.37  ? 112 LEU C CD2 1 
ATOM   5463 N  N   . GLN C 1 117 ? -49.64  13.941  20.787  1    58.41  ? 113 GLN C N   1 
ATOM   5464 C  CA  . GLN C 1 117 ? -49.07  12.885  19.943  1    57.25  ? 113 GLN C CA  1 
ATOM   5465 C  C   . GLN C 1 117 ? -48.12  11.987  20.75   1    53.08  ? 113 GLN C C   1 
ATOM   5466 O  O   . GLN C 1 117 ? -48.268 10.768  20.744  1    49.87  ? 113 GLN C O   1 
ATOM   5467 C  CB  . GLN C 1 117 ? -48.368 13.469  18.722  1    48.9   ? 113 GLN C CB  1 
ATOM   5468 C  CG  . GLN C 1 117 ? -49.322 14.163  17.772  1    56.26  ? 113 GLN C CG  1 
ATOM   5469 C  CD  . GLN C 1 117 ? -48.688 14.39   16.424  1    65.66  ? 113 GLN C CD  1 
ATOM   5470 O  OE1 . GLN C 1 117 ? -48.953 13.64   15.485  1    75.69  ? 113 GLN C OE1 1 
ATOM   5471 N  NE2 . GLN C 1 117 ? -47.808 15.377  16.316  1    64.73  ? 113 GLN C NE2 1 
ATOM   5472 N  N   . GLY C 1 118 ? -47.18  12.614  21.472  1    46.13  ? 114 GLY C N   1 
ATOM   5473 C  CA  . GLY C 1 118 ? -46.302 11.915  22.389  1    43.17  ? 114 GLY C CA  1 
ATOM   5474 C  C   . GLY C 1 118 ? -47.091 11.039  23.354  1    45.21  ? 114 GLY C C   1 
ATOM   5475 O  O   . GLY C 1 118 ? -46.737 9.873   23.593  1    46.74  ? 114 GLY C O   1 
ATOM   5476 N  N   . LEU C 1 119 ? -48.18  11.598  23.886  1    44.25  ? 115 LEU C N   1 
ATOM   5477 C  CA  . LEU C 1 119 ? -48.923 10.916  24.933  1    44.76  ? 115 LEU C CA  1 
ATOM   5478 C  C   . LEU C 1 119 ? -49.742 9.765   24.346  1    44.09  ? 115 LEU C C   1 
ATOM   5479 O  O   . LEU C 1 119 ? -49.812 8.686   24.945  1    43.8   ? 115 LEU C O   1 
ATOM   5480 C  CB  . LEU C 1 119 ? -49.76  11.893  25.754  1    42.77  ? 115 LEU C CB  1 
ATOM   5481 C  CG  . LEU C 1 119 ? -50.451 11.292  26.976  1    43.85  ? 115 LEU C CG  1 
ATOM   5482 C  CD1 . LEU C 1 119 ? -49.435 10.818  27.985  1    39.96  ? 115 LEU C CD1 1 
ATOM   5483 C  CD2 . LEU C 1 119 ? -51.396 12.303  27.617  1    45.25  ? 115 LEU C CD2 1 
ATOM   5484 N  N   . ALA C 1 120 ? -50.366 10.006  23.183  1    42.09  ? 116 ALA C N   1 
ATOM   5485 C  CA  . ALA C 1 120 ? -51.095 8.971   22.469  1    44.8   ? 116 ALA C CA  1 
ATOM   5486 C  C   . ALA C 1 120 ? -50.21  7.735   22.238  1    49.64  ? 116 ALA C C   1 
ATOM   5487 O  O   . ALA C 1 120 ? -50.667 6.59    22.342  1    51.88  ? 116 ALA C O   1 
ATOM   5488 C  CB  . ALA C 1 120 ? -51.61  9.534   21.175  1    41.91  ? 116 ALA C CB  1 
ATOM   5489 N  N   . PHE C 1 121 ? -48.934 7.981   21.914  1    48.55  ? 117 PHE C N   1 
ATOM   5490 C  CA  . PHE C 1 121 ? -47.944 6.934   21.703  1    48.26  ? 117 PHE C CA  1 
ATOM   5491 C  C   . PHE C 1 121 ? -47.643 6.171   23.003  1    46.9   ? 117 PHE C C   1 
ATOM   5492 O  O   . PHE C 1 121 ? -47.526 4.954   22.985  1    51.17  ? 117 PHE C O   1 
ATOM   5493 C  CB  . PHE C 1 121 ? -46.681 7.567   21.111  1    44.4   ? 117 PHE C CB  1 
ATOM   5494 C  CG  . PHE C 1 121 ? -45.793 6.549   20.426  1    47.48  ? 117 PHE C CG  1 
ATOM   5495 C  CD1 . PHE C 1 121 ? -44.886 5.785   21.173  1    48.87  ? 117 PHE C CD1 1 
ATOM   5496 C  CD2 . PHE C 1 121 ? -45.913 6.309   19.052  1    45.49  ? 117 PHE C CD2 1 
ATOM   5497 C  CE1 . PHE C 1 121 ? -44.085 4.826   20.545  1    46.05  ? 117 PHE C CE1 1 
ATOM   5498 C  CE2 . PHE C 1 121 ? -45.109 5.357   18.429  1    44.48  ? 117 PHE C CE2 1 
ATOM   5499 C  CZ  . PHE C 1 121 ? -44.193 4.62    19.172  1    43.51  ? 117 PHE C CZ  1 
ATOM   5500 N  N   . CYS C 1 122 ? -47.514 6.868   24.136  1    42.87  ? 118 CYS C N   1 
ATOM   5501 C  CA  . CYS C 1 122 ? -47.35  6.178   25.408  1    42.48  ? 118 CYS C CA  1 
ATOM   5502 C  C   . CYS C 1 122 ? -48.527 5.257   25.683  1    46.1   ? 118 CYS C C   1 
ATOM   5503 O  O   . CYS C 1 122 ? -48.326 4.078   25.962  1    50.6   ? 118 CYS C O   1 
ATOM   5504 C  CB  . CYS C 1 122 ? -47.2   7.146   26.564  1    39.3   ? 118 CYS C CB  1 
ATOM   5505 S  SG  . CYS C 1 122 ? -45.659 8.056   26.371  1    47.69  ? 118 CYS C SG  1 
ATOM   5506 N  N   . HIS C 1 123 ? -49.74  5.811   25.576  1    46.29  ? 119 HIS C N   1 
ATOM   5507 C  CA  . HIS C 1 123 ? -50.955 5.097   25.924  1    45.51  ? 119 HIS C CA  1 
ATOM   5508 C  C   . HIS C 1 123 ? -51.151 3.908   24.988  1    45.97  ? 119 HIS C C   1 
ATOM   5509 O  O   . HIS C 1 123 ? -51.532 2.838   25.464  1    48.9   ? 119 HIS C O   1 
ATOM   5510 C  CB  . HIS C 1 123 ? -52.135 6.07    26.043  1    46.64  ? 119 HIS C CB  1 
ATOM   5511 C  CG  . HIS C 1 123 ? -51.979 7.059   27.153  1    49.3   ? 119 HIS C CG  1 
ATOM   5512 N  ND1 . HIS C 1 123 ? -52.833 8.126   27.347  1    48.73  ? 119 HIS C ND1 1 
ATOM   5513 C  CD2 . HIS C 1 123 ? -51.075 7.131   28.143  1    48.47  ? 119 HIS C CD2 1 
ATOM   5514 C  CE1 . HIS C 1 123 ? -52.441 8.81    28.411  1    47.12  ? 119 HIS C CE1 1 
ATOM   5515 N  NE2 . HIS C 1 123 ? -51.375 8.234   28.901  1    49.98  ? 119 HIS C NE2 1 
ATOM   5516 N  N   . SER C 1 124 ? -50.974 4.14    23.669  1    45.52  ? 120 SER C N   1 
ATOM   5517 C  CA  . SER C 1 124 ? -50.98  3.127   22.619  1    43.89  ? 120 SER C CA  1 
ATOM   5518 C  C   . SER C 1 124 ? -49.999 2       22.939  1    47.24  ? 120 SER C C   1 
ATOM   5519 O  O   . SER C 1 124 ? -50.104 0.932   22.359  1    46.26  ? 120 SER C O   1 
ATOM   5520 C  CB  . SER C 1 124 ? -50.613 3.728   21.288  1    44.99  ? 120 SER C CB  1 
ATOM   5521 O  OG  . SER C 1 124 ? -51.679 4.479   20.734  1    55.08  ? 120 SER C OG  1 
ATOM   5522 N  N   . HIS C 1 125 ? -49.016 2.266   23.822  1    50.8   ? 121 HIS C N   1 
ATOM   5523 C  CA  . HIS C 1 125 ? -47.917 1.353   24.118  1    51.98  ? 121 HIS C CA  1 
ATOM   5524 C  C   . HIS C 1 125 ? -47.9   0.965   25.599  1    47     ? 121 HIS C C   1 
ATOM   5525 O  O   . HIS C 1 125 ? -46.846 0.67    26.145  1    41.06  ? 121 HIS C O   1 
ATOM   5526 C  CB  . HIS C 1 125 ? -46.589 1.968   23.643  1    50.74  ? 121 HIS C CB  1 
ATOM   5527 C  CG  . HIS C 1 125 ? -46.433 1.971   22.167  1    54.6   ? 121 HIS C CG  1 
ATOM   5528 N  ND1 . HIS C 1 125 ? -47.11  2.869   21.366  1    62.19  ? 121 HIS C ND1 1 
ATOM   5529 C  CD2 . HIS C 1 125 ? -45.738 1.189   21.334  1    54.23  ? 121 HIS C CD2 1 
ATOM   5530 C  CE1 . HIS C 1 125 ? -46.796 2.658   20.089  1    59.49  ? 121 HIS C CE1 1 
ATOM   5531 N  NE2 . HIS C 1 125 ? -45.961 1.644   20.051  1    61.23  ? 121 HIS C NE2 1 
ATOM   5532 N  N   . ARG C 1 126 ? -49.078 0.992   26.232  1    48.65  ? 122 ARG C N   1 
ATOM   5533 C  CA  . ARG C 1 126 ? -49.352 0.568   27.608  1    47.14  ? 122 ARG C CA  1 
ATOM   5534 C  C   . ARG C 1 126 ? -48.4   1.187   28.648  1    45.03  ? 122 ARG C C   1 
ATOM   5535 O  O   . ARG C 1 126 ? -48.137 0.569   29.681  1    47.49  ? 122 ARG C O   1 
ATOM   5536 C  CB  . ARG C 1 126 ? -49.481 -0.956  27.648  1    44.15  ? 122 ARG C CB  1 
ATOM   5537 C  CG  . ARG C 1 126 ? -48.266 -1.745  27.174  1    45.15  ? 122 ARG C CG  1 
ATOM   5538 C  CD  . ARG C 1 126 ? -47.263 -2.125  28.274  1    47.55  ? 122 ARG C CD  1 
ATOM   5539 N  NE  . ARG C 1 126 ? -46.128 -2.971  27.86   1    56.68  ? 122 ARG C NE  1 
ATOM   5540 C  CZ  . ARG C 1 126 ? -45.095 -2.614  27.055  1    50.66  ? 122 ARG C CZ  1 
ATOM   5541 N  NH1 . ARG C 1 126 ? -45.025 -1.415  26.495  1    49.46  ? 122 ARG C NH1 1 
ATOM   5542 N  NH2 . ARG C 1 126 ? -44.132 -3.47   26.793  1    47.13  ? 122 ARG C NH2 1 
ATOM   5543 N  N   . VAL C 1 127 ? -47.969 2.438   28.428  1    43.96  ? 123 VAL C N   1 
ATOM   5544 C  CA  . VAL C 1 127 ? -47.177 3.213   29.388  1    45.34  ? 123 VAL C CA  1 
ATOM   5545 C  C   . VAL C 1 127 ? -47.972 4.429   29.868  1    42.87  ? 123 VAL C C   1 
ATOM   5546 O  O   . VAL C 1 127 ? -48.389 5.266   29.061  1    40.77  ? 123 VAL C O   1 
ATOM   5547 C  CB  . VAL C 1 127 ? -45.835 3.69    28.78   1    44.41  ? 123 VAL C CB  1 
ATOM   5548 C  CG1 . VAL C 1 127 ? -45.147 4.753   29.632  1    36.4   ? 123 VAL C CG1 1 
ATOM   5549 C  CG2 . VAL C 1 127 ? -44.895 2.536   28.434  1    40.25  ? 123 VAL C CG2 1 
ATOM   5550 N  N   . LEU C 1 128 ? -48.175 4.5     31.188  1    41.02  ? 124 LEU C N   1 
ATOM   5551 C  CA  . LEU C 1 128 ? -48.578 5.731   31.866  1    41.84  ? 124 LEU C CA  1 
ATOM   5552 C  C   . LEU C 1 128 ? -47.33  6.553   32.168  1    39.7   ? 124 LEU C C   1 
ATOM   5553 O  O   . LEU C 1 128 ? -46.333 5.987   32.617  1    43.11  ? 124 LEU C O   1 
ATOM   5554 C  CB  . LEU C 1 128 ? -49.291 5.408   33.184  1    39.7   ? 124 LEU C CB  1 
ATOM   5555 C  CG  . LEU C 1 128 ? -50.635 4.668   33.126  1    41.24  ? 124 LEU C CG  1 
ATOM   5556 C  CD1 . LEU C 1 128 ? -51.191 4.647   34.56   1    37.95  ? 124 LEU C CD1 1 
ATOM   5557 C  CD2 . LEU C 1 128 ? -51.59  5.334   32.151  1    38.07  ? 124 LEU C CD2 1 
ATOM   5558 N  N   . HIS C 1 129 ? -47.412 7.883   32.023  1    39.39  ? 125 HIS C N   1 
ATOM   5559 C  CA  . HIS C 1 129 ? -46.29  8.758   32.354  1    40     ? 125 HIS C CA  1 
ATOM   5560 C  C   . HIS C 1 129 ? -46.31  9.12    33.846  1    43.51  ? 125 HIS C C   1 
ATOM   5561 O  O   . HIS C 1 129 ? -45.308 8.935   34.544  1    43.61  ? 125 HIS C O   1 
ATOM   5562 C  CB  . HIS C 1 129 ? -46.272 9.987   31.444  1    39.43  ? 125 HIS C CB  1 
ATOM   5563 C  CG  . HIS C 1 129 ? -45.099 10.87   31.669  1    44.6   ? 125 HIS C CG  1 
ATOM   5564 N  ND1 . HIS C 1 129 ? -44.959 11.687  32.781  1    40.86  ? 125 HIS C ND1 1 
ATOM   5565 C  CD2 . HIS C 1 129 ? -43.985 11.024  30.911  1    42.46  ? 125 HIS C CD2 1 
ATOM   5566 C  CE1 . HIS C 1 129 ? -43.787 12.317  32.693  1    43.73  ? 125 HIS C CE1 1 
ATOM   5567 N  NE2 . HIS C 1 129 ? -43.188 11.94   31.562  1    46.59  ? 125 HIS C NE2 1 
ATOM   5568 N  N   . ARG C 1 130 ? -47.45  9.669   34.308  1    41.37  ? 126 ARG C N   1 
ATOM   5569 C  CA  . ARG C 1 130 ? -47.749 9.887   35.718  1    43.75  ? 126 ARG C CA  1 
ATOM   5570 C  C   . ARG C 1 130 ? -46.937 11.02   36.354  1    45.22  ? 126 ARG C C   1 
ATOM   5571 O  O   . ARG C 1 130 ? -46.923 11.129  37.58   1    46.44  ? 126 ARG C O   1 
ATOM   5572 C  CB  . ARG C 1 130 ? -47.478 8.609   36.52   1    40.81  ? 126 ARG C CB  1 
ATOM   5573 C  CG  . ARG C 1 130 ? -48.278 7.415   36.026  1    39.19  ? 126 ARG C CG  1 
ATOM   5574 C  CD  . ARG C 1 130 ? -48.376 6.392   37.138  1    38.95  ? 126 ARG C CD  1 
ATOM   5575 N  NE  . ARG C 1 130 ? -47.057 5.85    37.481  1    40.81  ? 126 ARG C NE  1 
ATOM   5576 C  CZ  . ARG C 1 130 ? -46.864 4.906   38.396  1    45.46  ? 126 ARG C CZ  1 
ATOM   5577 N  NH1 . ARG C 1 130 ? -47.905 4.337   39.006  1    43.29  ? 126 ARG C NH1 1 
ATOM   5578 N  NH2 . ARG C 1 130 ? -45.622 4.528   38.682  1    46.44  ? 126 ARG C NH2 1 
ATOM   5579 N  N   . ASP C 1 131 ? -46.265 11.859  35.55   1    44.07  ? 127 ASP C N   1 
ATOM   5580 C  CA  . ASP C 1 131 ? -45.555 13.001  36.101  1    43.02  ? 127 ASP C CA  1 
ATOM   5581 C  C   . ASP C 1 131 ? -45.462 14.107  35.048  1    43.3   ? 127 ASP C C   1 
ATOM   5582 O  O   . ASP C 1 131 ? -44.426 14.748  34.869  1    41.88  ? 127 ASP C O   1 
ATOM   5583 C  CB  . ASP C 1 131 ? -44.204 12.623  36.684  1    43.14  ? 127 ASP C CB  1 
ATOM   5584 C  CG  . ASP C 1 131 ? -43.657 13.648  37.679  1    50.62  ? 127 ASP C CG  1 
ATOM   5585 O  OD1 . ASP C 1 131 ? -44.488 14.398  38.257  1    51.19  ? 127 ASP C OD1 1 
ATOM   5586 O  OD2 . ASP C 1 131 ? -42.402 13.74   37.823  1    51.47  ? 127 ASP C OD2 1 
ATOM   5587 N  N   . LEU C 1 132 ? -46.586 14.364  34.381  1    42.31  ? 128 LEU C N   1 
ATOM   5588 C  CA  . LEU C 1 132 ? -46.593 15.378  33.345  1    43.93  ? 128 LEU C CA  1 
ATOM   5589 C  C   . LEU C 1 132 ? -46.726 16.733  34.02   1    45.1   ? 128 LEU C C   1 
ATOM   5590 O  O   . LEU C 1 132 ? -47.751 17.02   34.596  1    54.76  ? 128 LEU C O   1 
ATOM   5591 C  CB  . LEU C 1 132 ? -47.712 15.1    32.336  1    41.88  ? 128 LEU C CB  1 
ATOM   5592 C  CG  . LEU C 1 132 ? -47.521 13.845  31.462  1    41.79  ? 128 LEU C CG  1 
ATOM   5593 C  CD1 . LEU C 1 132 ? -48.838 13.459  30.836  1    37.24  ? 128 LEU C CD1 1 
ATOM   5594 C  CD2 . LEU C 1 132 ? -46.423 14.026  30.398  1    37.51  ? 128 LEU C CD2 1 
ATOM   5595 N  N   . LYS C 1 133 ? -45.655 17.519  34.001  1    44.75  ? 129 LYS C N   1 
ATOM   5596 C  CA  . LYS C 1 133 ? -45.658 18.909  34.416  1    42.77  ? 129 LYS C CA  1 
ATOM   5597 C  C   . LYS C 1 133 ? -44.669 19.679  33.545  1    45.69  ? 129 LYS C C   1 
ATOM   5598 O  O   . LYS C 1 133 ? -43.788 19.093  32.929  1    42.6   ? 129 LYS C O   1 
ATOM   5599 C  CB  . LYS C 1 133 ? -45.245 19      35.882  1    41.85  ? 129 LYS C CB  1 
ATOM   5600 C  CG  . LYS C 1 133 ? -44.07  18.1    36.251  1    46.9   ? 129 LYS C CG  1 
ATOM   5601 C  CD  . LYS C 1 133 ? -43.594 18.269  37.69   1    49.51  ? 129 LYS C CD  1 
ATOM   5602 C  CE  . LYS C 1 133 ? -42.336 17.5    37.921  1    54.23  ? 129 LYS C CE  1 
ATOM   5603 N  NZ  . LYS C 1 133 ? -41.527 18.102  38.979  1    63.73  ? 129 LYS C NZ  1 
ATOM   5604 N  N   . PRO C 1 134 ? -44.727 21.026  33.513  1    49.37  ? 130 PRO C N   1 
ATOM   5605 C  CA  . PRO C 1 134 ? -43.896 21.798  32.589  1    45.65  ? 130 PRO C CA  1 
ATOM   5606 C  C   . PRO C 1 134 ? -42.41  21.451  32.634  1    46.49  ? 130 PRO C C   1 
ATOM   5607 O  O   . PRO C 1 134 ? -41.731 21.478  31.603  1    46.76  ? 130 PRO C O   1 
ATOM   5608 C  CB  . PRO C 1 134 ? -44.131 23.246  33.01   1    49.32  ? 130 PRO C CB  1 
ATOM   5609 C  CG  . PRO C 1 134 ? -45.419 23.242  33.798  1    50.1   ? 130 PRO C CG  1 
ATOM   5610 C  CD  . PRO C 1 134 ? -45.532 21.862  34.414  1    49.01  ? 130 PRO C CD  1 
ATOM   5611 N  N   . GLN C 1 135 ? -41.913 21.15   33.844  1    49.25  ? 131 GLN C N   1 
ATOM   5612 C  CA  . GLN C 1 135 ? -40.501 20.864  34.107  1    47.14  ? 131 GLN C CA  1 
ATOM   5613 C  C   . GLN C 1 135 ? -40.023 19.588  33.419  1    43.66  ? 131 GLN C C   1 
ATOM   5614 O  O   . GLN C 1 135 ? -38.823 19.413  33.294  1    46.77  ? 131 GLN C O   1 
ATOM   5615 C  CB  . GLN C 1 135 ? -40.194 20.678  35.583  1    44.32  ? 131 GLN C CB  1 
ATOM   5616 C  CG  . GLN C 1 135 ? -40.407 21.943  36.411  1    57     ? 131 GLN C CG  1 
ATOM   5617 C  CD  . GLN C 1 135 ? -41.798 22.189  36.972  1    57.61  ? 131 GLN C CD  1 
ATOM   5618 O  OE1 . GLN C 1 135 ? -42.8   21.537  36.647  1    53.74  ? 131 GLN C OE1 1 
ATOM   5619 N  NE2 . GLN C 1 135 ? -41.878 23.236  37.78   1    58.43  ? 131 GLN C NE2 1 
ATOM   5620 N  N   . ASN C 1 136 ? -40.959 18.714  33.014  1    42.33  ? 132 ASN C N   1 
ATOM   5621 C  CA  . ASN C 1 136 ? -40.691 17.407  32.43   1    39.71  ? 132 ASN C CA  1 
ATOM   5622 C  C   . ASN C 1 136 ? -40.954 17.421  30.92   1    40.81  ? 132 ASN C C   1 
ATOM   5623 O  O   . ASN C 1 136 ? -40.855 16.391  30.256  1    45.92  ? 132 ASN C O   1 
ATOM   5624 C  CB  . ASN C 1 136 ? -41.432 16.296  33.17   1    37.14  ? 132 ASN C CB  1 
ATOM   5625 C  CG  . ASN C 1 136 ? -40.937 16.072  34.596  1    43.18  ? 132 ASN C CG  1 
ATOM   5626 O  OD1 . ASN C 1 136 ? -39.924 16.66   35.035  1    38.55  ? 132 ASN C OD1 1 
ATOM   5627 N  ND2 . ASN C 1 136 ? -41.635 15.228  35.353  1    38.74  ? 132 ASN C ND2 1 
ATOM   5628 N  N   . LEU C 1 137 ? -41.267 18.594  30.364  1    38.29  ? 133 LEU C N   1 
ATOM   5629 C  CA  . LEU C 1 137 ? -41.471 18.761  28.936  1    39.34  ? 133 LEU C CA  1 
ATOM   5630 C  C   . LEU C 1 137 ? -40.342 19.636  28.393  1    44.8   ? 133 LEU C C   1 
ATOM   5631 O  O   . LEU C 1 137 ? -40.119 20.76   28.879  1    39.12  ? 133 LEU C O   1 
ATOM   5632 C  CB  . LEU C 1 137 ? -42.833 19.412  28.729  1    39.64  ? 133 LEU C CB  1 
ATOM   5633 C  CG  . LEU C 1 137 ? -43.991 18.736  29.47   1    39.36  ? 133 LEU C CG  1 
ATOM   5634 C  CD1 . LEU C 1 137 ? -45.267 19.524  29.274  1    44.32  ? 133 LEU C CD1 1 
ATOM   5635 C  CD2 . LEU C 1 137 ? -44.187 17.308  28.982  1    38.55  ? 133 LEU C CD2 1 
ATOM   5636 N  N   . LEU C 1 138 ? -39.64  19.095  27.374  1    44.12  ? 134 LEU C N   1 
ATOM   5637 C  CA  . LEU C 1 138 ? -38.454 19.737  26.828  1    44.56  ? 134 LEU C CA  1 
ATOM   5638 C  C   . LEU C 1 138 ? -38.722 20.259  25.412  1    44.21  ? 134 LEU C C   1 
ATOM   5639 O  O   . LEU C 1 138 ? -39.31  19.559  24.579  1    51     ? 134 LEU C O   1 
ATOM   5640 C  CB  . LEU C 1 138 ? -37.356 18.68   26.833  1    46.53  ? 134 LEU C CB  1 
ATOM   5641 C  CG  . LEU C 1 138 ? -37.093 18.005  28.182  1    50.79  ? 134 LEU C CG  1 
ATOM   5642 C  CD1 . LEU C 1 138 ? -35.995 16.979  27.964  1    62.31  ? 134 LEU C CD1 1 
ATOM   5643 C  CD2 . LEU C 1 138 ? -36.68  18.993  29.255  1    44.96  ? 134 LEU C CD2 1 
ATOM   5644 N  N   . ILE C 1 139 ? -38.283 21.498  25.158  1    40.38  ? 135 ILE C N   1 
ATOM   5645 C  CA  . ILE C 1 139 ? -38.43  22.143  23.859  1    42.83  ? 135 ILE C CA  1 
ATOM   5646 C  C   . ILE C 1 139 ? -37.043 22.322  23.241  1    45.02  ? 135 ILE C C   1 
ATOM   5647 O  O   . ILE C 1 139 ? -36.06  22.442  23.982  1    43.49  ? 135 ILE C O   1 
ATOM   5648 C  CB  . ILE C 1 139 ? -39.112 23.51   24.029  1    42.14  ? 135 ILE C CB  1 
ATOM   5649 C  CG1 . ILE C 1 139 ? -38.298 24.455  24.917  1    42.04  ? 135 ILE C CG1 1 
ATOM   5650 C  CG2 . ILE C 1 139 ? -40.544 23.328  24.525  1    41.81  ? 135 ILE C CG2 1 
ATOM   5651 C  CD1 . ILE C 1 139 ? -38.685 25.915  24.834  1    44.74  ? 135 ILE C CD1 1 
ATOM   5652 N  N   . ASN C 1 140 ? -36.979 22.355  21.898  1    45.04  ? 136 ASN C N   1 
ATOM   5653 C  CA  . ASN C 1 140 ? -35.772 22.8    21.198  1    49.18  ? 136 ASN C CA  1 
ATOM   5654 C  C   . ASN C 1 140 ? -36.003 24.155  20.521  1    51.19  ? 136 ASN C C   1 
ATOM   5655 O  O   . ASN C 1 140 ? -37.05  24.787  20.719  1    55.59  ? 136 ASN C O   1 
ATOM   5656 C  CB  . ASN C 1 140 ? -35.185 21.739  20.271  1    48.47  ? 136 ASN C CB  1 
ATOM   5657 C  CG  . ASN C 1 140 ? -36.099 21.351  19.122  1    51.5   ? 136 ASN C CG  1 
ATOM   5658 O  OD1 . ASN C 1 140 ? -37.05  22.072  18.775  1    48.04  ? 136 ASN C OD1 1 
ATOM   5659 N  ND2 . ASN C 1 140 ? -35.839 20.186  18.546  1    48.49  ? 136 ASN C ND2 1 
ATOM   5660 N  N   . THR C 1 141 ? -35.013 24.574  19.719  1    54.78  ? 137 THR C N   1 
ATOM   5661 C  CA  . THR C 1 141 ? -35.029 25.855  19.016  1    63.2   ? 137 THR C CA  1 
ATOM   5662 C  C   . THR C 1 141 ? -35.912 25.815  17.765  1    66.48  ? 137 THR C C   1 
ATOM   5663 O  O   . THR C 1 141 ? -36.177 26.857  17.174  1    73.14  ? 137 THR C O   1 
ATOM   5664 C  CB  . THR C 1 141 ? -33.62  26.325  18.645  1    61.77  ? 137 THR C CB  1 
ATOM   5665 O  OG1 . THR C 1 141 ? -33.072 25.344  17.781  1    71.42  ? 137 THR C OG1 1 
ATOM   5666 C  CG2 . THR C 1 141 ? -32.683 26.491  19.819  1    63.03  ? 137 THR C CG2 1 
ATOM   5667 N  N   . GLU C 1 142 ? -36.349 24.622  17.341  1    66.77  ? 138 GLU C N   1 
ATOM   5668 C  CA  . GLU C 1 142 ? -37.045 24.459  16.07   1    67.63  ? 138 GLU C CA  1 
ATOM   5669 C  C   . GLU C 1 142 ? -38.546 24.229  16.253  1    67.95  ? 138 GLU C C   1 
ATOM   5670 O  O   . GLU C 1 142 ? -39.211 23.835  15.301  1    70.24  ? 138 GLU C O   1 
ATOM   5671 C  CB  . GLU C 1 142 ? -36.435 23.29   15.295  1    66.96  ? 138 GLU C CB  1 
ATOM   5672 C  CG  . GLU C 1 142 ? -34.945 23.477  15.027  1    81.77  ? 138 GLU C CG  1 
ATOM   5673 C  CD  . GLU C 1 142 ? -34.51  23.076  13.627  1    99.46  ? 138 GLU C CD  1 
ATOM   5674 O  OE1 . GLU C 1 142 ? -34.73  21.886  13.269  1    94.12  ? 138 GLU C OE1 1 
ATOM   5675 O  OE2 . GLU C 1 142 ? -33.969 23.963  12.9    1    98.2   ? 138 GLU C OE2 1 
ATOM   5676 N  N   . GLY C 1 143 ? -39.057 24.436  17.475  1    62.28  ? 139 GLY C N   1 
ATOM   5677 C  CA  . GLY C 1 143 ? -40.478 24.415  17.775  1    58.92  ? 139 GLY C CA  1 
ATOM   5678 C  C   . GLY C 1 143 ? -41     23.007  18.06   1    57.64  ? 139 GLY C C   1 
ATOM   5679 O  O   . GLY C 1 143 ? -42.2   22.741  17.954  1    58.53  ? 139 GLY C O   1 
ATOM   5680 N  N   . ALA C 1 144 ? -40.089 22.115  18.448  1    54.34  ? 140 ALA C N   1 
ATOM   5681 C  CA  . ALA C 1 144 ? -40.463 20.783  18.894  1    51.52  ? 140 ALA C CA  1 
ATOM   5682 C  C   . ALA C 1 144 ? -40.65  20.814  20.411  1    47.07  ? 140 ALA C C   1 
ATOM   5683 O  O   . ALA C 1 144 ? -39.929 21.544  21.092  1    47.05  ? 140 ALA C O   1 
ATOM   5684 C  CB  . ALA C 1 144 ? -39.39  19.779  18.462  1    45.29  ? 140 ALA C CB  1 
ATOM   5685 N  N   . ILE C 1 145 ? -41.592 19.999  20.915  1    45.74  ? 141 ILE C N   1 
ATOM   5686 C  CA  . ILE C 1 145 ? -41.669 19.688  22.337  1    50.07  ? 141 ILE C CA  1 
ATOM   5687 C  C   . ILE C 1 145 ? -41.723 18.17   22.545  1    46.64  ? 141 ILE C C   1 
ATOM   5688 O  O   . ILE C 1 145 ? -42.303 17.463  21.731  1    46.71  ? 141 ILE C O   1 
ATOM   5689 C  CB  . ILE C 1 145 ? -42.843 20.439  23.014  1    52.01  ? 141 ILE C CB  1 
ATOM   5690 C  CG1 . ILE C 1 145 ? -42.821 20.295  24.522  1    48.84  ? 141 ILE C CG1 1 
ATOM   5691 C  CG2 . ILE C 1 145 ? -44.198 20.017  22.44   1    49.64  ? 141 ILE C CG2 1 
ATOM   5692 C  CD1 . ILE C 1 145 ? -43.685 21.307  25.262  1    48.97  ? 141 ILE C CD1 1 
ATOM   5693 N  N   . LYS C 1 146 ? -41.165 17.69   23.663  1    45.3   ? 142 LYS C N   1 
ATOM   5694 C  CA  . LYS C 1 146 ? -41.067 16.258  23.931  1    45.31  ? 142 LYS C CA  1 
ATOM   5695 C  C   . LYS C 1 146 ? -41.307 15.955  25.417  1    43     ? 142 LYS C C   1 
ATOM   5696 O  O   . LYS C 1 146 ? -40.836 16.69   26.284  1    44.98  ? 142 LYS C O   1 
ATOM   5697 C  CB  . LYS C 1 146 ? -39.682 15.724  23.543  1    42.95  ? 142 LYS C CB  1 
ATOM   5698 C  CG  . LYS C 1 146 ? -39.281 16.02   22.127  1    45.28  ? 142 LYS C CG  1 
ATOM   5699 C  CD  . LYS C 1 146 ? -38.063 15.267  21.619  1    43.47  ? 142 LYS C CD  1 
ATOM   5700 C  CE  . LYS C 1 146 ? -37.585 15.798  20.263  1    43.61  ? 142 LYS C CE  1 
ATOM   5701 N  NZ  . LYS C 1 146 ? -36.661 14.844  19.608  1    42.07  ? 142 LYS C NZ  1 
ATOM   5702 N  N   . LEU C 1 147 ? -42.027 14.858  25.685  1    39.36  ? 143 LEU C N   1 
ATOM   5703 C  CA  . LEU C 1 147 ? -42.233 14.323  27.017  1    39.28  ? 143 LEU C CA  1 
ATOM   5704 C  C   . LEU C 1 147 ? -40.889 13.817  27.511  1    42.4   ? 143 LEU C C   1 
ATOM   5705 O  O   . LEU C 1 147 ? -40.194 13.126  26.771  1    47.41  ? 143 LEU C O   1 
ATOM   5706 C  CB  . LEU C 1 147 ? -43.193 13.131  26.979  1    37.56  ? 143 LEU C CB  1 
ATOM   5707 C  CG  . LEU C 1 147 ? -44.531 13.309  26.259  1    41.22  ? 143 LEU C CG  1 
ATOM   5708 C  CD1 . LEU C 1 147 ? -45.449 12.14   26.472  1    42.38  ? 143 LEU C CD1 1 
ATOM   5709 C  CD2 . LEU C 1 147 ? -45.233 14.532  26.722  1    47.44  ? 143 LEU C CD2 1 
ATOM   5710 N  N   . ALA C 1 148 ? -40.565 14.071  28.777  1    39.9   ? 144 ALA C N   1 
ATOM   5711 C  CA  . ALA C 1 148 ? -39.308 13.546  29.316  1    45.64  ? 144 ALA C CA  1 
ATOM   5712 C  C   . ALA C 1 148 ? -39.517 13.084  30.76   1    42.05  ? 144 ALA C C   1 
ATOM   5713 O  O   . ALA C 1 148 ? -40.647 13.085  31.221  1    41.01  ? 144 ALA C O   1 
ATOM   5714 C  CB  . ALA C 1 148 ? -38.213 14.603  29.219  1    41.92  ? 144 ALA C CB  1 
ATOM   5715 N  N   . ASP C 1 149 ? -38.425 12.724  31.443  1    43.5   ? 145 ASP C N   1 
ATOM   5716 C  CA  . ASP C 1 149 ? -38.424 12.164  32.787  1    47.24  ? 145 ASP C CA  1 
ATOM   5717 C  C   . ASP C 1 149 ? -39.449 11.041  32.939  1    43.61  ? 145 ASP C C   1 
ATOM   5718 O  O   . ASP C 1 149 ? -40.539 11.265  33.461  1    44.23  ? 145 ASP C O   1 
ATOM   5719 C  CB  . ASP C 1 149 ? -38.537 13.233  33.871  1    54.09  ? 145 ASP C CB  1 
ATOM   5720 C  CG  . ASP C 1 149 ? -38.007 12.781  35.234  1    70.04  ? 145 ASP C CG  1 
ATOM   5721 O  OD1 . ASP C 1 149 ? -37.789 11.541  35.43   1    61.46  ? 145 ASP C OD1 1 
ATOM   5722 O  OD2 . ASP C 1 149 ? -37.756 13.672  36.088  1    72.71  ? 145 ASP C OD2 1 
ATOM   5723 N  N   . PHE C 1 150 ? -39.081 9.828   32.518  1    42.17  ? 146 PHE C N   1 
ATOM   5724 C  CA  . PHE C 1 150 ? -39.986 8.69    32.59   1    39.82  ? 146 PHE C CA  1 
ATOM   5725 C  C   . PHE C 1 150 ? -39.698 7.831   33.821  1    44.41  ? 146 PHE C C   1 
ATOM   5726 O  O   . PHE C 1 150 ? -39.942 6.626   33.802  1    49.52  ? 146 PHE C O   1 
ATOM   5727 C  CB  . PHE C 1 150 ? -39.889 7.861   31.306  1    40.23  ? 146 PHE C CB  1 
ATOM   5728 C  CG  . PHE C 1 150 ? -40.658 8.458   30.145  1    38.02  ? 146 PHE C CG  1 
ATOM   5729 C  CD1 . PHE C 1 150 ? -40.257 9.671   29.599  1    36.92  ? 146 PHE C CD1 1 
ATOM   5730 C  CD2 . PHE C 1 150 ? -41.804 7.833   29.649  1    37.08  ? 146 PHE C CD2 1 
ATOM   5731 C  CE1 . PHE C 1 150 ? -40.966 10.252  28.546  1    37.97  ? 146 PHE C CE1 1 
ATOM   5732 C  CE2 . PHE C 1 150 ? -42.519 8.425   28.61   1    37.8   ? 146 PHE C CE2 1 
ATOM   5733 C  CZ  . PHE C 1 150 ? -42.067 9.608   28.026  1    35.64  ? 146 PHE C CZ  1 
ATOM   5734 N  N   . GLY C 1 151 ? -39.21  8.459   34.901  1    49     ? 147 GLY C N   1 
ATOM   5735 C  CA  . GLY C 1 151 ? -38.791 7.747   36.109  1    52.76  ? 147 GLY C CA  1 
ATOM   5736 C  C   . GLY C 1 151 ? -39.977 7.33    36.969  1    50.73  ? 147 GLY C C   1 
ATOM   5737 O  O   . GLY C 1 151 ? -39.849 6.393   37.739  1    53     ? 147 GLY C O   1 
ATOM   5738 N  N   . LEU C 1 152 ? -41.105 8.052   36.839  1    51.99  ? 148 LEU C N   1 
ATOM   5739 C  CA  . LEU C 1 152 ? -42.338 7.729   37.532  1    50.38  ? 148 LEU C CA  1 
ATOM   5740 C  C   . LEU C 1 152 ? -43.291 6.975   36.614  1    51.46  ? 148 LEU C C   1 
ATOM   5741 O  O   . LEU C 1 152 ? -44.474 6.843   36.944  1    61.03  ? 148 LEU C O   1 
ATOM   5742 C  CB  . LEU C 1 152 ? -43.007 8.997   38.046  1    56.14  ? 148 LEU C CB  1 
ATOM   5743 C  CG  . LEU C 1 152 ? -42.241 9.775   39.123  1    68.93  ? 148 LEU C CG  1 
ATOM   5744 C  CD1 . LEU C 1 152 ? -42.98  11.071  39.401  1    74.16  ? 148 LEU C CD1 1 
ATOM   5745 C  CD2 . LEU C 1 152 ? -42.1   8.907   40.38   1    82.64  ? 148 LEU C CD2 1 
ATOM   5746 N  N   . ALA C 1 153 ? -42.794 6.527   35.455  1    44.81  ? 149 ALA C N   1 
ATOM   5747 C  CA  . ALA C 1 153 ? -43.654 5.909   34.455  1    41.7   ? 149 ALA C CA  1 
ATOM   5748 C  C   . ALA C 1 153 ? -43.903 4.447   34.81   1    44.25  ? 149 ALA C C   1 
ATOM   5749 O  O   . ALA C 1 153 ? -43.203 3.864   35.633  1    46.18  ? 149 ALA C O   1 
ATOM   5750 C  CB  . ALA C 1 153 ? -43.028 6.032   33.088  1    40.08  ? 149 ALA C CB  1 
ATOM   5751 N  N   . ARG C 1 154 ? -44.882 3.832   34.143  1    42.26  ? 150 ARG C N   1 
ATOM   5752 C  CA  . ARG C 1 154 ? -45.309 2.502   34.548  1    43.16  ? 150 ARG C CA  1 
ATOM   5753 C  C   . ARG C 1 154 ? -45.986 1.801   33.369  1    43.71  ? 150 ARG C C   1 
ATOM   5754 O  O   . ARG C 1 154 ? -46.842 2.369   32.684  1    46.27  ? 150 ARG C O   1 
ATOM   5755 C  CB  . ARG C 1 154 ? -46.116 2.68    35.846  1    43.52  ? 150 ARG C CB  1 
ATOM   5756 C  CG  . ARG C 1 154 ? -47.227 1.664   36.031  1    46.26  ? 150 ARG C CG  1 
ATOM   5757 C  CD  . ARG C 1 154 ? -46.721 0.403   36.617  1    51.56  ? 150 ARG C CD  1 
ATOM   5758 N  NE  . ARG C 1 154 ? -46.69  0.39    38.084  1    47.8   ? 150 ARG C NE  1 
ATOM   5759 C  CZ  . ARG C 1 154 ? -46.645 -0.759  38.764  1    47.14  ? 150 ARG C CZ  1 
ATOM   5760 N  NH1 . ARG C 1 154 ? -46.634 -0.744  40.085  1    49.49  ? 150 ARG C NH1 1 
ATOM   5761 N  NH2 . ARG C 1 154 ? -46.628 -1.925  38.121  1    43.33  ? 150 ARG C NH2 1 
ATOM   5762 N  N   . ALA C 1 155 ? -45.568 0.567   33.103  1    42.85  ? 151 ALA C N   1 
ATOM   5763 C  CA  . ALA C 1 155 ? -46.229 -0.21   32.072  1    42.64  ? 151 ALA C CA  1 
ATOM   5764 C  C   . ALA C 1 155 ? -47.513 -0.748  32.688  1    49.54  ? 151 ALA C C   1 
ATOM   5765 O  O   . ALA C 1 155 ? -47.477 -1.283  33.801  1    57.93  ? 151 ALA C O   1 
ATOM   5766 C  CB  . ALA C 1 155 ? -45.307 -1.313  31.581  1    38.55  ? 151 ALA C CB  1 
ATOM   5767 N  N   . PHE C 1 156 ? -48.651 -0.563  32.007  1    47.71  ? 152 PHE C N   1 
ATOM   5768 C  CA  . PHE C 1 156 ? -49.917 -0.993  32.595  1    47.91  ? 152 PHE C CA  1 
ATOM   5769 C  C   . PHE C 1 156 ? -50.491 -2.194  31.851  1    50.54  ? 152 PHE C C   1 
ATOM   5770 O  O   . PHE C 1 156 ? -50.16  -2.419  30.688  1    52.57  ? 152 PHE C O   1 
ATOM   5771 C  CB  . PHE C 1 156 ? -50.935 0.15    32.672  1    45.31  ? 152 PHE C CB  1 
ATOM   5772 C  CG  . PHE C 1 156 ? -51.407 0.77    31.373  1    45.49  ? 152 PHE C CG  1 
ATOM   5773 C  CD1 . PHE C 1 156 ? -52.563 0.305   30.737  1    45.7   ? 152 PHE C CD1 1 
ATOM   5774 C  CD2 . PHE C 1 156 ? -50.758 1.885   30.846  1    46.96  ? 152 PHE C CD2 1 
ATOM   5775 C  CE1 . PHE C 1 156 ? -53.033 0.906   29.562  1    47.33  ? 152 PHE C CE1 1 
ATOM   5776 C  CE2 . PHE C 1 156 ? -51.226 2.488   29.672  1    50.67  ? 152 PHE C CE2 1 
ATOM   5777 C  CZ  . PHE C 1 156 ? -52.369 2.001   29.025  1    46.18  ? 152 PHE C CZ  1 
ATOM   5778 N  N   . GLY C 1 157 ? -51.361 -2.954  32.527  1    51.05  ? 153 GLY C N   1 
ATOM   5779 C  CA  . GLY C 1 157 ? -52.13  -3.989  31.854  1    51.35  ? 153 GLY C CA  1 
ATOM   5780 C  C   . GLY C 1 157 ? -53.553 -3.499  31.567  1    53.97  ? 153 GLY C C   1 
ATOM   5781 O  O   . GLY C 1 157 ? -53.922 -2.414  32.026  1    55.37  ? 153 GLY C O   1 
ATOM   5782 N  N   . VAL C 1 158 ? -54.328 -4.302  30.815  1    49.95  ? 154 VAL C N   1 
ATOM   5783 C  CA  . VAL C 1 158 ? -55.681 -3.965  30.392  1    52.64  ? 154 VAL C CA  1 
ATOM   5784 C  C   . VAL C 1 158 ? -56.601 -5.083  30.887  1    57.13  ? 154 VAL C C   1 
ATOM   5785 O  O   . VAL C 1 158 ? -56.445 -6.227  30.455  1    63.82  ? 154 VAL C O   1 
ATOM   5786 C  CB  . VAL C 1 158 ? -55.734 -3.879  28.846  1    52.14  ? 154 VAL C CB  1 
ATOM   5787 C  CG1 . VAL C 1 158 ? -57.123 -3.555  28.305  1    50.9   ? 154 VAL C CG1 1 
ATOM   5788 C  CG2 . VAL C 1 158 ? -54.663 -2.977  28.231  1    46.85  ? 154 VAL C CG2 1 
ATOM   5789 N  N   . PRO C 1 159 ? -57.547 -4.862  31.836  1    58.54  ? 155 PRO C N   1 
ATOM   5790 C  CA  . PRO C 1 159 ? -57.737 -3.578  32.524  1    55.53  ? 155 PRO C CA  1 
ATOM   5791 C  C   . PRO C 1 159 ? -56.611 -3.251  33.502  1    55.79  ? 155 PRO C C   1 
ATOM   5792 O  O   . PRO C 1 159 ? -55.832 -4.132  33.893  1    55.04  ? 155 PRO C O   1 
ATOM   5793 C  CB  . PRO C 1 159 ? -59.059 -3.83   33.312  1    56.45  ? 155 PRO C CB  1 
ATOM   5794 C  CG  . PRO C 1 159 ? -59.038 -5.319  33.645  1    56.66  ? 155 PRO C CG  1 
ATOM   5795 C  CD  . PRO C 1 159 ? -58.443 -5.916  32.37   1    57.97  ? 155 PRO C CD  1 
ATOM   5796 N  N   . VAL C 1 160 ? -56.556 -1.978  33.924  1    54.07  ? 156 VAL C N   1 
ATOM   5797 C  CA  . VAL C 1 160 ? -55.515 -1.532  34.838  1    51.38  ? 156 VAL C CA  1 
ATOM   5798 C  C   . VAL C 1 160 ? -55.767 -2.251  36.147  1    50.2   ? 156 VAL C C   1 
ATOM   5799 O  O   . VAL C 1 160 ? -56.905 -2.666  36.375  1    50.88  ? 156 VAL C O   1 
ATOM   5800 C  CB  . VAL C 1 160 ? -55.52  -0.006  35.037  1    48.86  ? 156 VAL C CB  1 
ATOM   5801 C  CG1 . VAL C 1 160 ? -55.295 0.747   33.724  1    51.27  ? 156 VAL C CG1 1 
ATOM   5802 C  CG2 . VAL C 1 160 ? -56.804 0.459   35.665  1    45.96  ? 156 VAL C CG2 1 
ATOM   5803 N  N   . ARG C 1 161 ? -54.744 -2.245  36.993  1    50.89  ? 157 ARG C N   1 
ATOM   5804 C  CA  . ARG C 1 161 ? -54.875 -2.759  38.369  1    55.69  ? 157 ARG C CA  1 
ATOM   5805 C  C   . ARG C 1 161 ? -54.408 -1.621  39.289  1    52.13  ? 157 ARG C C   1 
ATOM   5806 O  O   . ARG C 1 161 ? -54.118 -0.536  38.774  1    48.52  ? 157 ARG C O   1 
ATOM   5807 C  CB  . ARG C 1 161 ? -54.054 -4.04   38.529  1    61.26  ? 157 ARG C CB  1 
ATOM   5808 C  CG  . ARG C 1 161 ? -52.543 -3.885  38.572  1    66.85  ? 157 ARG C CG  1 
ATOM   5809 C  CD  . ARG C 1 161 ? -51.916 -4.872  39.535  1    75.38  ? 157 ARG C CD  1 
ATOM   5810 N  NE  . ARG C 1 161 ? -50.607 -4.412  40.007  1    84.82  ? 157 ARG C NE  1 
ATOM   5811 C  CZ  . ARG C 1 161 ? -49.45  -4.893  39.582  1    79.42  ? 157 ARG C CZ  1 
ATOM   5812 N  NH1 . ARG C 1 161 ? -49.43  -5.81   38.633  1    79.63  ? 157 ARG C NH1 1 
ATOM   5813 N  NH2 . ARG C 1 161 ? -48.321 -4.458  40.107  1    73.07  ? 157 ARG C NH2 1 
ATOM   5814 N  N   . THR C 1 162 ? -54.363 -1.855  40.593  1    54.46  ? 158 THR C N   1 
ATOM   5815 C  CA  . THR C 1 162 ? -53.922 -0.857  41.568  1    53.36  ? 158 THR C CA  1 
ATOM   5816 C  C   . THR C 1 162 ? -52.41  -0.651  41.426  1    54.24  ? 158 THR C C   1 
ATOM   5817 O  O   . THR C 1 162 ? -51.64  -1.624  41.499  1    54.59  ? 158 THR C O   1 
ATOM   5818 C  CB  . THR C 1 162 ? -54.332 -1.295  42.985  1    56.42  ? 158 THR C CB  1 
ATOM   5819 O  OG1 . THR C 1 162 ? -55.755 -1.204  42.983  1    61.44  ? 158 THR C OG1 1 
ATOM   5820 C  CG2 . THR C 1 162 ? -53.8   -0.431  44.122  1    51.77  ? 158 THR C CG2 1 
ATOM   5821 N  N   . TYR C 1 163 ? -52.019 0.624   41.217  1    49.61  ? 159 TYR C N   1 
ATOM   5822 C  CA  . TYR C 1 163 ? -50.637 1.073   41.109  1    44.24  ? 159 TYR C CA  1 
ATOM   5823 C  C   . TYR C 1 163 ? -50.338 2.014   42.265  1    47.19  ? 159 TYR C C   1 
ATOM   5824 O  O   . TYR C 1 163 ? -51.154 2.141   43.173  1    54.28  ? 159 TYR C O   1 
ATOM   5825 C  CB  . TYR C 1 163 ? -50.438 1.753   39.757  1    45.21  ? 159 TYR C CB  1 
ATOM   5826 C  CG  . TYR C 1 163 ? -50.801 0.861   38.581  1    47.33  ? 159 TYR C CG  1 
ATOM   5827 C  CD1 . TYR C 1 163 ? -50.386 -0.46   38.541  1    50.84  ? 159 TYR C CD1 1 
ATOM   5828 C  CD2 . TYR C 1 163 ? -51.57  1.338   37.53   1    45.9   ? 159 TYR C CD2 1 
ATOM   5829 C  CE1 . TYR C 1 163 ? -50.712 -1.278  37.479  1    52.44  ? 159 TYR C CE1 1 
ATOM   5830 C  CE2 . TYR C 1 163 ? -51.895 0.533   36.462  1    47.06  ? 159 TYR C CE2 1 
ATOM   5831 C  CZ  . TYR C 1 163 ? -51.462 -0.782  36.429  1    52     ? 159 TYR C CZ  1 
ATOM   5832 O  OH  . TYR C 1 163 ? -51.807 -1.643  35.408  1    56.49  ? 159 TYR C OH  1 
HETATM 5833 N  N   . TPO C 1 164 ? -49.16  2.646   42.256  1    48.09  ? 160 TPO C N   1 
HETATM 5834 C  CA  . TPO C 1 164 ? -48.736 3.524   43.336  1    52.5   ? 160 TPO C CA  1 
HETATM 5835 C  CB  . TPO C 1 164 ? -47.27  3.941   43.133  1    55.7   ? 160 TPO C CB  1 
HETATM 5836 C  CG2 . TPO C 1 164 ? -46.696 4.737   44.28   1    52.99  ? 160 TPO C CG2 1 
HETATM 5837 O  OG1 . TPO C 1 164 ? -46.455 2.722   42.994  1    57.12  ? 160 TPO C OG1 1 
HETATM 5838 P  P   . TPO C 1 164 ? -45.811 2.331   41.548  1    48.08  ? 160 TPO C P   1 
HETATM 5839 O  O1P . TPO C 1 164 ? -46.962 2.08    40.629  1    49.04  ? 160 TPO C O1P 1 
HETATM 5840 O  O2P . TPO C 1 164 ? -44.954 1.124   41.806  1    45.97  ? 160 TPO C O2P 1 
HETATM 5841 O  O3P . TPO C 1 164 ? -45.002 3.533   41.091  1    48.15  ? 160 TPO C O3P 1 
HETATM 5842 C  C   . TPO C 1 164 ? -49.662 4.741   43.398  1    55.82  ? 160 TPO C C   1 
HETATM 5843 O  O   . TPO C 1 164 ? -50.006 5.293   42.354  1    55.55  ? 160 TPO C O   1 
ATOM   5844 N  N   . HIS C 1 165 ? -50.041 5.166   44.616  1    61.65  ? 161 HIS C N   1 
ATOM   5845 C  CA  . HIS C 1 165 ? -50.932 6.308   44.798  1    68.88  ? 161 HIS C CA  1 
ATOM   5846 C  C   . HIS C 1 165 ? -50.168 7.641   44.812  1    70.56  ? 161 HIS C C   1 
ATOM   5847 O  O   . HIS C 1 165 ? -50.646 8.665   44.301  1    62.27  ? 161 HIS C O   1 
ATOM   5848 C  CB  . HIS C 1 165 ? -51.806 6.105   46.036  1    73.71  ? 161 HIS C CB  1 
ATOM   5849 C  CG  . HIS C 1 165 ? -52.449 7.37    46.508  1    97.04  ? 161 HIS C CG  1 
ATOM   5850 N  ND1 . HIS C 1 165 ? -53.721 7.738   46.128  1    101.17 ? 161 HIS C ND1 1 
ATOM   5851 C  CD2 . HIS C 1 165 ? -52.002 8.366   47.312  1    95.1   ? 161 HIS C CD2 1 
ATOM   5852 C  CE1 . HIS C 1 165 ? -54.021 8.902   46.697  1    104.33 ? 161 HIS C CE1 1 
ATOM   5853 N  NE2 . HIS C 1 165 ? -52.995 9.301   47.414  1    97.23  ? 161 HIS C NE2 1 
ATOM   5854 N  N   A GLU C 1 166 ? -48.978 7.647   45.426  0.5  77.58  ? 162 GLU C N   1 
ATOM   5855 N  N   B GLU C 1 166 ? -48.982 7.604   45.426  0.5  74.53  ? 162 GLU C N   1 
ATOM   5856 C  CA  A GLU C 1 166 ? -48.175 8.86    45.509  0.5  80.6   ? 162 GLU C CA  1 
ATOM   5857 C  CA  B GLU C 1 166 ? -48.093 8.748   45.504  0.5  75.3   ? 162 GLU C CA  1 
ATOM   5858 C  C   A GLU C 1 166 ? -47.584 9.124   44.122  0.5  76.14  ? 162 GLU C C   1 
ATOM   5859 C  C   B GLU C 1 166 ? -47.583 9.055   44.089  0.5  72.92  ? 162 GLU C C   1 
ATOM   5860 O  O   A GLU C 1 166 ? -46.43  8.792   43.84   0.5  76.9   ? 162 GLU C O   1 
ATOM   5861 O  O   B GLU C 1 166 ? -46.458 8.681   43.748  0.5  73.31  ? 162 GLU C O   1 
ATOM   5862 C  CB  A GLU C 1 166 ? -47.209 8.777   46.7    0.5  83     ? 162 GLU C CB  1 
ATOM   5863 C  CB  B GLU C 1 166 ? -46.963 8.422   46.497  0.5  72.86  ? 162 GLU C CB  1 
ATOM   5864 C  CG  A GLU C 1 166 ? -46.304 9.993   46.87   0.5  80.35  ? 162 GLU C CG  1 
ATOM   5865 C  CG  B GLU C 1 166 ? -47.386 7.739   47.804  0.5  68.98  ? 162 GLU C CG  1 
ATOM   5866 C  CD  A GLU C 1 166 ? -46.982 11.346  46.781  0.5  75.69  ? 162 GLU C CD  1 
ATOM   5867 C  CD  B GLU C 1 166 ? -47.743 6.252   47.788  0.5  62.49  ? 162 GLU C CD  1 
ATOM   5868 O  OE1 A GLU C 1 166 ? -46.899 11.928  45.677  0.5  72.57  ? 162 GLU C OE1 1 
ATOM   5869 O  OE1 B GLU C 1 166 ? -46.857 5.376   47.649  0.5  60.12  ? 162 GLU C OE1 1 
ATOM   5870 O  OE2 A GLU C 1 166 ? -47.53  11.825  47.801  0.5  68.44  ? 162 GLU C OE2 1 
ATOM   5871 O  OE2 B GLU C 1 166 ? -48.943 5.959   47.92   0.5  60.33  ? 162 GLU C OE2 1 
ATOM   5872 N  N   . VAL C 1 167 ? -48.405 9.721   43.258  1    65.68  ? 163 VAL C N   1 
ATOM   5873 C  CA  . VAL C 1 167 ? -48.056 9.865   41.84   1    65.02  ? 163 VAL C CA  1 
ATOM   5874 C  C   . VAL C 1 167 ? -48.529 11.231  41.35   1    59.62  ? 163 VAL C C   1 
ATOM   5875 O  O   . VAL C 1 167 ? -49.628 11.654  41.737  1    55.92  ? 163 VAL C O   1 
ATOM   5876 C  CB  . VAL C 1 167 ? -48.601 8.756   40.9    1    65.75  ? 163 VAL C CB  1 
ATOM   5877 C  CG1 . VAL C 1 167 ? -47.834 7.448   41.018  1    58.19  ? 163 VAL C CG1 1 
ATOM   5878 C  CG2 . VAL C 1 167 ? -50.095 8.516   41.104  1    69.99  ? 163 VAL C CG2 1 
ATOM   5879 N  N   . VAL C 1 168 ? -47.712 11.875  40.488  1    51.07  ? 164 VAL C N   1 
ATOM   5880 C  CA  . VAL C 1 168 ? -48.045 13.164  39.881  1    53.48  ? 164 VAL C CA  1 
ATOM   5881 C  C   . VAL C 1 168 ? -47.811 14.27   40.925  1    50.89  ? 164 VAL C C   1 
ATOM   5882 O  O   . VAL C 1 168 ? -48.3   14.219  42.06   1    53     ? 164 VAL C O   1 
ATOM   5883 C  CB  . VAL C 1 168 ? -49.439 13.303  39.198  1    54.03  ? 164 VAL C CB  1 
ATOM   5884 C  CG1 . VAL C 1 168 ? -49.522 14.498  38.264  1    51.28  ? 164 VAL C CG1 1 
ATOM   5885 C  CG2 . VAL C 1 168 ? -49.918 12.061  38.444  1    49.22  ? 164 VAL C CG2 1 
ATOM   5886 N  N   . THR C 1 169 ? -47.039 15.284  40.543  1    49     ? 165 THR C N   1 
ATOM   5887 C  CA  . THR C 1 169 ? -46.883 16.47   41.372  1    56.11  ? 165 THR C CA  1 
ATOM   5888 C  C   . THR C 1 169 ? -48.274 17.055  41.644  1    53.57  ? 165 THR C C   1 
ATOM   5889 O  O   . THR C 1 169 ? -49.117 17.101  40.738  1    57.91  ? 165 THR C O   1 
ATOM   5890 C  CB  . THR C 1 169 ? -45.947 17.431  40.621  1    60.51  ? 165 THR C CB  1 
ATOM   5891 O  OG1 . THR C 1 169 ? -44.734 16.683  40.531  1    67.38  ? 165 THR C OG1 1 
ATOM   5892 C  CG2 . THR C 1 169 ? -45.723 18.75   41.343  1    53.38  ? 165 THR C CG2 1 
ATOM   5893 N  N   . LEU C 1 170 ? -48.492 17.511  42.882  1    48.49  ? 166 LEU C N   1 
ATOM   5894 C  CA  . LEU C 1 170 ? -49.813 17.88   43.374  1    50.9   ? 166 LEU C CA  1 
ATOM   5895 C  C   . LEU C 1 170 ? -50.63  18.705  42.369  1    49.89  ? 166 LEU C C   1 
ATOM   5896 O  O   . LEU C 1 170 ? -51.766 18.365  42.047  1    55.68  ? 166 LEU C O   1 
ATOM   5897 C  CB  . LEU C 1 170 ? -49.629 18.654  44.684  1    49.83  ? 166 LEU C CB  1 
ATOM   5898 C  CG  . LEU C 1 170 ? -50.925 18.997  45.429  1    49.91  ? 166 LEU C CG  1 
ATOM   5899 C  CD1 . LEU C 1 170 ? -51.769 17.756  45.741  1    46.96  ? 166 LEU C CD1 1 
ATOM   5900 C  CD2 . LEU C 1 170 ? -50.602 19.763  46.706  1    49.16  ? 166 LEU C CD2 1 
ATOM   5901 N  N   . TRP C 1 171 ? -50.071 19.826  41.916  1    45.27  ? 167 TRP C N   1 
ATOM   5902 C  CA  . TRP C 1 171 ? -50.791 20.753  41.065  1    46.29  ? 167 TRP C CA  1 
ATOM   5903 C  C   . TRP C 1 171 ? -51.393 20.073  39.832  1    45.99  ? 167 TRP C C   1 
ATOM   5904 O  O   . TRP C 1 171 ? -52.37  20.57   39.293  1    47.85  ? 167 TRP C O   1 
ATOM   5905 C  CB  . TRP C 1 171 ? -49.862 21.896  40.638  1    43.98  ? 167 TRP C CB  1 
ATOM   5906 C  CG  . TRP C 1 171 ? -49.368 22.758  41.754  1    46.1   ? 167 TRP C CG  1 
ATOM   5907 C  CD1 . TRP C 1 171 ? -49.681 22.679  43.082  1    48.29  ? 167 TRP C CD1 1 
ATOM   5908 C  CD2 . TRP C 1 171 ? -48.493 23.888  41.618  1    47.7   ? 167 TRP C CD2 1 
ATOM   5909 N  NE1 . TRP C 1 171 ? -49.063 23.673  43.777  1    44.4   ? 167 TRP C NE1 1 
ATOM   5910 C  CE2 . TRP C 1 171 ? -48.331 24.436  42.912  1    47.93  ? 167 TRP C CE2 1 
ATOM   5911 C  CE3 . TRP C 1 171 ? -47.851 24.489  40.535  1    49.55  ? 167 TRP C CE3 1 
ATOM   5912 C  CZ2 . TRP C 1 171 ? -47.544 25.556  43.156  1    50.43  ? 167 TRP C CZ2 1 
ATOM   5913 C  CZ3 . TRP C 1 171 ? -47.078 25.602  40.783  1    55.38  ? 167 TRP C CZ3 1 
ATOM   5914 C  CH2 . TRP C 1 171 ? -46.924 26.122  42.07   1    53.67  ? 167 TRP C CH2 1 
ATOM   5915 N  N   . TYR C 1 172 ? -50.795 18.968  39.366  1    46.63  ? 168 TYR C N   1 
ATOM   5916 C  CA  . TYR C 1 172 ? -51.153 18.344  38.091  1    43.4   ? 168 TYR C CA  1 
ATOM   5917 C  C   . TYR C 1 172 ? -51.869 17.029  38.364  1    43.8   ? 168 TYR C C   1 
ATOM   5918 O  O   . TYR C 1 172 ? -52.114 16.237  37.455  1    49.49  ? 168 TYR C O   1 
ATOM   5919 C  CB  . TYR C 1 172 ? -49.881 18.183  37.237  1    40.69  ? 168 TYR C CB  1 
ATOM   5920 C  CG  . TYR C 1 172 ? -49.189 19.519  37.035  1    39.58  ? 168 TYR C CG  1 
ATOM   5921 C  CD1 . TYR C 1 172 ? -49.595 20.387  36.027  1    38.95  ? 168 TYR C CD1 1 
ATOM   5922 C  CD2 . TYR C 1 172 ? -48.227 19.961  37.934  1    39.46  ? 168 TYR C CD2 1 
ATOM   5923 C  CE1 . TYR C 1 172 ? -49.055 21.656  35.898  1    40.77  ? 168 TYR C CE1 1 
ATOM   5924 C  CE2 . TYR C 1 172 ? -47.664 21.221  37.801  1    42.66  ? 168 TYR C CE2 1 
ATOM   5925 C  CZ  . TYR C 1 172 ? -48.071 22.074  36.781  1    45.94  ? 168 TYR C CZ  1 
ATOM   5926 O  OH  . TYR C 1 172 ? -47.496 23.327  36.689  1    50.18  ? 168 TYR C OH  1 
ATOM   5927 N  N   . ARG C 1 173 ? -52.239 16.804  39.631  1    48.2   ? 169 ARG C N   1 
ATOM   5928 C  CA  . ARG C 1 173 ? -52.803 15.524  40.06   1    46.95  ? 169 ARG C CA  1 
ATOM   5929 C  C   . ARG C 1 173 ? -54.313 15.504  39.815  1    47.94  ? 169 ARG C C   1 
ATOM   5930 O  O   . ARG C 1 173 ? -55.038 16.404  40.247  1    48.88  ? 169 ARG C O   1 
ATOM   5931 C  CB  . ARG C 1 173 ? -52.489 15.259  41.538  1    43.31  ? 169 ARG C CB  1 
ATOM   5932 C  CG  . ARG C 1 173 ? -52.957 13.884  41.985  1    44.86  ? 169 ARG C CG  1 
ATOM   5933 C  CD  . ARG C 1 173 ? -52.493 13.545  43.382  1    45.25  ? 169 ARG C CD  1 
ATOM   5934 N  NE  . ARG C 1 173 ? -51.064 13.812  43.595  1    46.96  ? 169 ARG C NE  1 
ATOM   5935 C  CZ  . ARG C 1 173 ? -50.515 14.096  44.79   1    51.76  ? 169 ARG C CZ  1 
ATOM   5936 N  NH1 . ARG C 1 173 ? -51.221 14.097  45.922  1    49.49  ? 169 ARG C NH1 1 
ATOM   5937 N  NH2 . ARG C 1 173 ? -49.236 14.394  44.859  1    52.63  ? 169 ARG C NH2 1 
ATOM   5938 N  N   . ALA C 1 174 ? -54.778 14.449  39.133  1    52.28  ? 170 ALA C N   1 
ATOM   5939 C  CA  . ALA C 1 174 ? -56.179 14.283  38.735  1    48.81  ? 170 ALA C CA  1 
ATOM   5940 C  C   . ALA C 1 174 ? -57.057 14.071  39.969  1    49.17  ? 170 ALA C C   1 
ATOM   5941 O  O   . ALA C 1 174 ? -56.623 13.495  40.965  1    49.84  ? 170 ALA C O   1 
ATOM   5942 C  CB  . ALA C 1 174 ? -56.289 13.121  37.779  1    40.59  ? 170 ALA C CB  1 
ATOM   5943 N  N   . PRO C 1 175 ? -58.323 14.517  39.954  1    46.58  ? 171 PRO C N   1 
ATOM   5944 C  CA  . PRO C 1 175 ? -59.186 14.363  41.118  1    50.42  ? 171 PRO C CA  1 
ATOM   5945 C  C   . PRO C 1 175 ? -59.436 12.927  41.58   1    55.92  ? 171 PRO C C   1 
ATOM   5946 O  O   . PRO C 1 175 ? -59.646 12.704  42.771  1    59.7   ? 171 PRO C O   1 
ATOM   5947 C  CB  . PRO C 1 175 ? -60.467 15.096  40.696  1    52.44  ? 171 PRO C CB  1 
ATOM   5948 C  CG  . PRO C 1 175 ? -60.438 15.054  39.186  1    49.37  ? 171 PRO C CG  1 
ATOM   5949 C  CD  . PRO C 1 175 ? -58.971 15.189  38.83   1    47.44  ? 171 PRO C CD  1 
ATOM   5950 N  N   . GLU C 1 176 ? -59.387 11.949  40.659  1    54.78  ? 172 GLU C N   1 
ATOM   5951 C  CA  . GLU C 1 176 ? -59.594 10.561  41.046  1    54.36  ? 172 GLU C CA  1 
ATOM   5952 C  C   . GLU C 1 176 ? -58.446 10.07   41.922  1    53.84  ? 172 GLU C C   1 
ATOM   5953 O  O   . GLU C 1 176 ? -58.67  9.236   42.786  1    58.57  ? 172 GLU C O   1 
ATOM   5954 C  CB  . GLU C 1 176 ? -59.872 9.609   39.881  1    56.94  ? 172 GLU C CB  1 
ATOM   5955 C  CG  . GLU C 1 176 ? -58.768 9.513   38.828  1    53.9   ? 172 GLU C CG  1 
ATOM   5956 C  CD  . GLU C 1 176 ? -58.871 10.487  37.654  1    55.55  ? 172 GLU C CD  1 
ATOM   5957 O  OE1 . GLU C 1 176 ? -58.38  10.1    36.558  1    49.33  ? 172 GLU C OE1 1 
ATOM   5958 O  OE2 . GLU C 1 176 ? -59.429 11.626  37.823  1    54.76  ? 172 GLU C OE2 1 
ATOM   5959 N  N   . ILE C 1 177 ? -57.222 10.571  41.703  1    55.08  ? 173 ILE C N   1 
ATOM   5960 C  CA  . ILE C 1 177 ? -56.115 10.188  42.579  1    55.97  ? 173 ILE C CA  1 
ATOM   5961 C  C   . ILE C 1 177 ? -56.278 10.885  43.931  1    58.1   ? 173 ILE C C   1 
ATOM   5962 O  O   . ILE C 1 177 ? -56.041 10.294  44.974  1    58.18  ? 173 ILE C O   1 
ATOM   5963 C  CB  . ILE C 1 177 ? -54.735 10.449  41.941  1    52.03  ? 173 ILE C CB  1 
ATOM   5964 C  CG1 . ILE C 1 177 ? -54.572 9.769   40.608  1    50.09  ? 173 ILE C CG1 1 
ATOM   5965 C  CG2 . ILE C 1 177 ? -53.601 9.997   42.848  1    54.98  ? 173 ILE C CG2 1 
ATOM   5966 C  CD1 . ILE C 1 177 ? -53.372 10.31   39.843  1    54.91  ? 173 ILE C CD1 1 
ATOM   5967 N  N   . LEU C 1 178 ? -56.715 12.145  43.907  1    60.56  ? 174 LEU C N   1 
ATOM   5968 C  CA  . LEU C 1 178 ? -56.855 12.947  45.115  1    58.59  ? 174 LEU C CA  1 
ATOM   5969 C  C   . LEU C 1 178 ? -57.89  12.334  46.048  1    63.36  ? 174 LEU C C   1 
ATOM   5970 O  O   . LEU C 1 178 ? -57.662 12.317  47.249  1    68.06  ? 174 LEU C O   1 
ATOM   5971 C  CB  . LEU C 1 178 ? -57.228 14.378  44.741  1    54.23  ? 174 LEU C CB  1 
ATOM   5972 C  CG  . LEU C 1 178 ? -56.083 15.239  44.204  1    53.53  ? 174 LEU C CG  1 
ATOM   5973 C  CD1 . LEU C 1 178 ? -56.671 16.46   43.488  1    54.94  ? 174 LEU C CD1 1 
ATOM   5974 C  CD2 . LEU C 1 178 ? -55.154 15.652  45.361  1    53.97  ? 174 LEU C CD2 1 
ATOM   5975 N  N   . LEU C 1 179 ? -59.003 11.84   45.481  1    64.65  ? 175 LEU C N   1 
ATOM   5976 C  CA  . LEU C 1 179 ? -60.1   11.234  46.22   1    61.69  ? 175 LEU C CA  1 
ATOM   5977 C  C   . LEU C 1 179 ? -59.851 9.746   46.484  1    62.98  ? 175 LEU C C   1 
ATOM   5978 O  O   . LEU C 1 179 ? -60.809 9.031   46.781  1    65.57  ? 175 LEU C O   1 
ATOM   5979 C  CB  . LEU C 1 179 ? -61.392 11.439  45.428  1    62.98  ? 175 LEU C CB  1 
ATOM   5980 C  CG  . LEU C 1 179 ? -61.901 12.878  45.311  1    66.62  ? 175 LEU C CG  1 
ATOM   5981 C  CD1 . LEU C 1 179 ? -63.111 12.992  44.407  1    68.38  ? 175 LEU C CD1 1 
ATOM   5982 C  CD2 . LEU C 1 179 ? -62.229 13.494  46.663  1    73.42  ? 175 LEU C CD2 1 
ATOM   5983 N  N   . GLY C 1 180 ? -58.592 9.288   46.321  1    59.87  ? 176 GLY C N   1 
ATOM   5984 C  CA  . GLY C 1 180 ? -58.084 7.991   46.749  1    57.13  ? 176 GLY C CA  1 
ATOM   5985 C  C   . GLY C 1 180 ? -58.759 6.815   46.051  1    61.16  ? 176 GLY C C   1 
ATOM   5986 O  O   . GLY C 1 180 ? -58.986 5.786   46.679  1    63.25  ? 176 GLY C O   1 
ATOM   5987 N  N   . CYS C 1 181 ? -59.132 6.994   44.776  1    60.98  ? 177 CYS C N   1 
ATOM   5988 C  CA  . CYS C 1 181 ? -59.824 5.957   44.026  1    62.24  ? 177 CYS C CA  1 
ATOM   5989 C  C   . CYS C 1 181 ? -58.909 4.748   43.892  1    60.56  ? 177 CYS C C   1 
ATOM   5990 O  O   . CYS C 1 181 ? -57.703 4.932   43.785  1    58.61  ? 177 CYS C O   1 
ATOM   5991 C  CB  . CYS C 1 181 ? -60.192 6.431   42.625  1    67.81  ? 177 CYS C CB  1 
ATOM   5992 S  SG  . CYS C 1 181 ? -61.664 7.495   42.556  1    84.1   ? 177 CYS C SG  1 
ATOM   5993 N  N   . LYS C 1 182 ? -59.494 3.545   43.92   1    61.46  ? 178 LYS C N   1 
ATOM   5994 C  CA  . LYS C 1 182 ? -58.762 2.29    43.823  1    63.72  ? 178 LYS C CA  1 
ATOM   5995 C  C   . LYS C 1 182 ? -57.98  2.171   42.511  1    61.91  ? 178 LYS C C   1 
ATOM   5996 O  O   . LYS C 1 182 ? -56.854 1.684   42.532  1    62.26  ? 178 LYS C O   1 
ATOM   5997 C  CB  . LYS C 1 182 ? -59.704 1.08    43.879  1    70.36  ? 178 LYS C CB  1 
ATOM   5998 C  CG  . LYS C 1 182 ? -59.041 -0.266  44.207  1    74.85  ? 178 LYS C CG  1 
ATOM   5999 C  CD  . LYS C 1 182 ? -60.031 -1.424  44.186  1    81.48  ? 178 LYS C CD  1 
ATOM   6000 C  CE  . LYS C 1 182 ? -59.514 -2.79   44.548  1    80.5   ? 178 LYS C CE  1 
ATOM   6001 N  NZ  . LYS C 1 182 ? -60.552 -3.817  44.315  1    73.97  ? 178 LYS C NZ  1 
ATOM   6002 N  N   . TYR C 1 183 ? -58.59  2.574   41.384  1    57.47  ? 179 TYR C N   1 
ATOM   6003 C  CA  . TYR C 1 183 ? -57.962 2.455   40.081  1    56.56  ? 179 TYR C CA  1 
ATOM   6004 C  C   . TYR C 1 183 ? -57.913 3.802   39.365  1    60.87  ? 179 TYR C C   1 
ATOM   6005 O  O   . TYR C 1 183 ? -58.892 4.559   39.379  1    69.89  ? 179 TYR C O   1 
ATOM   6006 C  CB  . TYR C 1 183 ? -58.757 1.583   39.11   1    56.15  ? 179 TYR C CB  1 
ATOM   6007 C  CG  . TYR C 1 183 ? -59.03  0.162   39.568  1    61.6   ? 179 TYR C CG  1 
ATOM   6008 C  CD1 . TYR C 1 183 ? -57.995 -0.739  39.758  1    62.11  ? 179 TYR C CD1 1 
ATOM   6009 C  CD2 . TYR C 1 183 ? -60.331 -0.291  39.765  1    64.51  ? 179 TYR C CD2 1 
ATOM   6010 C  CE1 . TYR C 1 183 ? -58.23  -2.039  40.176  1    64.48  ? 179 TYR C CE1 1 
ATOM   6011 C  CE2 . TYR C 1 183 ? -60.582 -1.586  40.175  1    62.36  ? 179 TYR C CE2 1 
ATOM   6012 C  CZ  . TYR C 1 183 ? -59.535 -2.465  40.361  1    66.44  ? 179 TYR C CZ  1 
ATOM   6013 O  OH  . TYR C 1 183 ? -59.826 -3.735  40.765  1    81.52  ? 179 TYR C OH  1 
ATOM   6014 N  N   . TYR C 1 184 ? -56.773 4.053   38.704  1    55.22  ? 180 TYR C N   1 
ATOM   6015 C  CA  . TYR C 1 184 ? -56.63  5.15    37.765  1    51.26  ? 180 TYR C CA  1 
ATOM   6016 C  C   . TYR C 1 184 ? -55.983 4.61    36.491  1    51.35  ? 180 TYR C C   1 
ATOM   6017 O  O   . TYR C 1 184 ? -55.45  3.501   36.467  1    49.19  ? 180 TYR C O   1 
ATOM   6018 C  CB  . TYR C 1 184 ? -55.824 6.293   38.388  1    53.33  ? 180 TYR C CB  1 
ATOM   6019 C  CG  . TYR C 1 184 ? -54.38  5.965   38.737  1    49.6   ? 180 TYR C CG  1 
ATOM   6020 C  CD1 . TYR C 1 184 ? -53.387 5.984   37.771  1    44.68  ? 180 TYR C CD1 1 
ATOM   6021 C  CD2 . TYR C 1 184 ? -54.021 5.634   40.043  1    52.37  ? 180 TYR C CD2 1 
ATOM   6022 C  CE1 . TYR C 1 184 ? -52.081 5.673   38.099  1    50.15  ? 180 TYR C CE1 1 
ATOM   6023 C  CE2 . TYR C 1 184 ? -52.709 5.327   40.382  1    50.56  ? 180 TYR C CE2 1 
ATOM   6024 C  CZ  . TYR C 1 184 ? -51.731 5.326   39.401  1    52.61  ? 180 TYR C CZ  1 
ATOM   6025 O  OH  . TYR C 1 184 ? -50.425 4.984   39.701  1    54.29  ? 180 TYR C OH  1 
ATOM   6026 N  N   . SER C 1 185 ? -56.011 5.433   35.439  1    50.41  ? 181 SER C N   1 
ATOM   6027 C  CA  . SER C 1 185 ? -55.71  4.997   34.086  1    50.78  ? 181 SER C CA  1 
ATOM   6028 C  C   . SER C 1 185 ? -55.147 6.164   33.278  1    48.29  ? 181 SER C C   1 
ATOM   6029 O  O   . SER C 1 185 ? -54.722 7.177   33.863  1    47.37  ? 181 SER C O   1 
ATOM   6030 C  CB  . SER C 1 185 ? -56.953 4.443   33.42   1    53.56  ? 181 SER C CB  1 
ATOM   6031 O  OG  . SER C 1 185 ? -56.689 3.758   32.194  1    55.49  ? 181 SER C OG  1 
ATOM   6032 N  N   . THR C 1 186 ? -55.161 5.991   31.946  1    44.93  ? 182 THR C N   1 
ATOM   6033 C  CA  . THR C 1 186 ? -54.645 6.952   30.978  1    49.33  ? 182 THR C CA  1 
ATOM   6034 C  C   . THR C 1 186 ? -55.235 8.337   31.199  1    48.15  ? 182 THR C C   1 
ATOM   6035 O  O   . THR C 1 186 ? -54.617 9.326   30.825  1    47.52  ? 182 THR C O   1 
ATOM   6036 C  CB  . THR C 1 186 ? -54.918 6.51    29.544  1    47.35  ? 182 THR C CB  1 
ATOM   6037 O  OG1 . THR C 1 186 ? -56.329 6.427   29.474  1    50.8   ? 182 THR C OG1 1 
ATOM   6038 C  CG2 . THR C 1 186 ? -54.216 5.209   29.206  1    43.82  ? 182 THR C CG2 1 
ATOM   6039 N  N   . ALA C 1 187 ? -56.412 8.405   31.826  1    51.07  ? 183 ALA C N   1 
ATOM   6040 C  CA  . ALA C 1 187 ? -57.099 9.677   32.017  1    52.8   ? 183 ALA C CA  1 
ATOM   6041 C  C   . ALA C 1 187 ? -56.275 10.662  32.863  1    50.93  ? 183 ALA C C   1 
ATOM   6042 O  O   . ALA C 1 187 ? -56.392 11.869  32.671  1    53.82  ? 183 ALA C O   1 
ATOM   6043 C  CB  . ALA C 1 187 ? -58.499 9.449   32.548  1    47.51  ? 183 ALA C CB  1 
ATOM   6044 N  N   . VAL C 1 188 ? -55.443 10.154  33.784  1    49.1   ? 184 VAL C N   1 
ATOM   6045 C  CA  . VAL C 1 188 ? -54.697 10.995  34.701  1    46.2   ? 184 VAL C CA  1 
ATOM   6046 C  C   . VAL C 1 188 ? -53.694 11.815  33.898  1    48.22  ? 184 VAL C C   1 
ATOM   6047 O  O   . VAL C 1 188 ? -53.449 12.979  34.218  1    57.94  ? 184 VAL C O   1 
ATOM   6048 C  CB  . VAL C 1 188 ? -54.013 10.253  35.872  1    45.47  ? 184 VAL C CB  1 
ATOM   6049 C  CG1 . VAL C 1 188 ? -54.961 9.271   36.541  1    45.2   ? 184 VAL C CG1 1 
ATOM   6050 C  CG2 . VAL C 1 188 ? -52.71  9.561   35.476  1    45.39  ? 184 VAL C CG2 1 
ATOM   6051 N  N   . ASP C 1 189 ? -53.118 11.201  32.863  1    43.93  ? 185 ASP C N   1 
ATOM   6052 C  CA  . ASP C 1 189 ? -52.156 11.895  32.027  1    44.55  ? 185 ASP C CA  1 
ATOM   6053 C  C   . ASP C 1 189 ? -52.833 13.033  31.269  1    45.22  ? 185 ASP C C   1 
ATOM   6054 O  O   . ASP C 1 189 ? -52.191 14.054  31.018  1    52.64  ? 185 ASP C O   1 
ATOM   6055 C  CB  . ASP C 1 189 ? -51.41  10.94   31.107  1    41.57  ? 185 ASP C CB  1 
ATOM   6056 C  CG  . ASP C 1 189 ? -50.29  10.128  31.749  1    43.35  ? 185 ASP C CG  1 
ATOM   6057 O  OD1 . ASP C 1 189 ? -49.747 10.551  32.799  1    41.42  ? 185 ASP C OD1 1 
ATOM   6058 O  OD2 . ASP C 1 189 ? -49.963 9.061   31.192  1    44.48  ? 185 ASP C OD2 1 
ATOM   6059 N  N   . ILE C 1 190 ? -54.111 12.856  30.89   1    42.4   ? 186 ILE C N   1 
ATOM   6060 C  CA  . ILE C 1 190 ? -54.832 13.872  30.144  1    42.75  ? 186 ILE C CA  1 
ATOM   6061 C  C   . ILE C 1 190 ? -55.113 15.064  31.056  1    44.79  ? 186 ILE C C   1 
ATOM   6062 O  O   . ILE C 1 190 ? -54.992 16.215  30.631  1    45.88  ? 186 ILE C O   1 
ATOM   6063 C  CB  . ILE C 1 190 ? -56.119 13.316  29.489  1    49.34  ? 186 ILE C CB  1 
ATOM   6064 C  CG1 . ILE C 1 190 ? -55.81  12.404  28.291  1    47.21  ? 186 ILE C CG1 1 
ATOM   6065 C  CG2 . ILE C 1 190 ? -57.112 14.425  29.095  1    43.45  ? 186 ILE C CG2 1 
ATOM   6066 C  CD1 . ILE C 1 190 ? -55.289 13.156  27.08   1    46.46  ? 186 ILE C CD1 1 
ATOM   6067 N  N   . TRP C 1 191 ? -55.504 14.784  32.306  1    44     ? 187 TRP C N   1 
ATOM   6068 C  CA  . TRP C 1 191 ? -55.763 15.819  33.291  1    43.35  ? 187 TRP C CA  1 
ATOM   6069 C  C   . TRP C 1 191 ? -54.557 16.756  33.379  1    45.17  ? 187 TRP C C   1 
ATOM   6070 O  O   . TRP C 1 191 ? -54.653 17.97   33.238  1    49.39  ? 187 TRP C O   1 
ATOM   6071 C  CB  . TRP C 1 191 ? -56.08  15.178  34.647  1    43.45  ? 187 TRP C CB  1 
ATOM   6072 C  CG  . TRP C 1 191 ? -56.345 16.214  35.7    1    44.54  ? 187 TRP C CG  1 
ATOM   6073 C  CD1 . TRP C 1 191 ? -55.408 16.841  36.466  1    43.78  ? 187 TRP C CD1 1 
ATOM   6074 C  CD2 . TRP C 1 191 ? -57.617 16.819  36.032  1    45.53  ? 187 TRP C CD2 1 
ATOM   6075 N  NE1 . TRP C 1 191 ? -56.016 17.767  37.277  1    46.14  ? 187 TRP C NE1 1 
ATOM   6076 C  CE2 . TRP C 1 191 ? -57.363 17.788  37.026  1    44.08  ? 187 TRP C CE2 1 
ATOM   6077 C  CE3 . TRP C 1 191 ? -58.934 16.626  35.6    1    46.63  ? 187 TRP C CE3 1 
ATOM   6078 C  CZ2 . TRP C 1 191 ? -58.373 18.549  37.596  1    45.4   ? 187 TRP C CZ2 1 
ATOM   6079 C  CZ3 . TRP C 1 191 ? -59.942 17.366  36.173  1    48.15  ? 187 TRP C CZ3 1 
ATOM   6080 C  CH2 . TRP C 1 191 ? -59.659 18.327  37.146  1    50.64  ? 187 TRP C CH2 1 
ATOM   6081 N  N   . SER C 1 192 ? -53.394 16.171  33.594  1    41.87  ? 188 SER C N   1 
ATOM   6082 C  CA  . SER C 1 192 ? -52.164 16.925  33.664  1    40.92  ? 188 SER C CA  1 
ATOM   6083 C  C   . SER C 1 192 ? -51.996 17.843  32.445  1    41.17  ? 188 SER C C   1 
ATOM   6084 O  O   . SER C 1 192 ? -51.689 19.027  32.588  1    42.84  ? 188 SER C O   1 
ATOM   6085 C  CB  . SER C 1 192 ? -50.985 15.976  33.853  1    42.15  ? 188 SER C CB  1 
ATOM   6086 O  OG  . SER C 1 192 ? -51.092 15.143  35.011  1    40.57  ? 188 SER C OG  1 
ATOM   6087 N  N   . LEU C 1 193 ? -52.172 17.299  31.243  1    39.88  ? 189 LEU C N   1 
ATOM   6088 C  CA  . LEU C 1 193 ? -51.978 18.07   30.033  1    40.83  ? 189 LEU C CA  1 
ATOM   6089 C  C   . LEU C 1 193 ? -52.998 19.196  30.001  1    44.56  ? 189 LEU C C   1 
ATOM   6090 O  O   . LEU C 1 193 ? -52.728 20.287  29.508  1    47.31  ? 189 LEU C O   1 
ATOM   6091 C  CB  . LEU C 1 193 ? -52.11  17.196  28.786  1    41.1   ? 189 LEU C CB  1 
ATOM   6092 C  CG  . LEU C 1 193 ? -50.877 16.39   28.374  1    43.93  ? 189 LEU C CG  1 
ATOM   6093 C  CD1 . LEU C 1 193 ? -51.055 15.816  26.972  1    43.74  ? 189 LEU C CD1 1 
ATOM   6094 C  CD2 . LEU C 1 193 ? -49.601 17.21   28.425  1    39.53  ? 189 LEU C CD2 1 
ATOM   6095 N  N   . GLY C 1 194 ? -54.194 18.921  30.512  1    45.15  ? 190 GLY C N   1 
ATOM   6096 C  CA  . GLY C 1 194 ? -55.198 19.966  30.595  1    43.08  ? 190 GLY C CA  1 
ATOM   6097 C  C   . GLY C 1 194 ? -54.701 21.128  31.451  1    43.31  ? 190 GLY C C   1 
ATOM   6098 O  O   . GLY C 1 194 ? -54.759 22.275  31.01   1    46.72  ? 190 GLY C O   1 
ATOM   6099 N  N   . CYS C 1 195 ? -54.197 20.808  32.652  1    41.44  ? 191 CYS C N   1 
ATOM   6100 C  CA  . CYS C 1 195 ? -53.558 21.769  33.529  1    45.58  ? 191 CYS C CA  1 
ATOM   6101 C  C   . CYS C 1 195 ? -52.422 22.515  32.816  1    50.89  ? 191 CYS C C   1 
ATOM   6102 O  O   . CYS C 1 195 ? -52.252 23.721  32.998  1    49.78  ? 191 CYS C O   1 
ATOM   6103 C  CB  . CYS C 1 195 ? -53.085 21.077  34.796  1    46.18  ? 191 CYS C CB  1 
ATOM   6104 S  SG  . CYS C 1 195 ? -54.453 20.339  35.743  1    49.72  ? 191 CYS C SG  1 
ATOM   6105 N  N   . ILE C 1 196 ? -51.657 21.802  31.979  1    49.88  ? 192 ILE C N   1 
ATOM   6106 C  CA  . ILE C 1 196 ? -50.554 22.401  31.24   1    51.87  ? 192 ILE C CA  1 
ATOM   6107 C  C   . ILE C 1 196 ? -51.075 23.306  30.115  1    52.03  ? 192 ILE C C   1 
ATOM   6108 O  O   . ILE C 1 196 ? -50.515 24.386  29.891  1    50.9   ? 192 ILE C O   1 
ATOM   6109 C  CB  . ILE C 1 196 ? -49.553 21.317  30.765  1    50.61  ? 192 ILE C CB  1 
ATOM   6110 C  CG1 . ILE C 1 196 ? -48.756 20.781  31.961  1    44.6   ? 192 ILE C CG1 1 
ATOM   6111 C  CG2 . ILE C 1 196 ? -48.624 21.812  29.647  1    41.54  ? 192 ILE C CG2 1 
ATOM   6112 C  CD1 . ILE C 1 196 ? -48.411 19.311  31.845  1    48.76  ? 192 ILE C CD1 1 
ATOM   6113 N  N   . PHE C 1 197 ? -52.14  22.864  29.415  1    48.75  ? 193 PHE C N   1 
ATOM   6114 C  CA  . PHE C 1 197 ? -52.772 23.692  28.402  1    45.2   ? 193 PHE C CA  1 
ATOM   6115 C  C   . PHE C 1 197 ? -53.104 25.047  29.015  1    46.49  ? 193 PHE C C   1 
ATOM   6116 O  O   . PHE C 1 197 ? -52.747 26.058  28.453  1    47.7   ? 193 PHE C O   1 
ATOM   6117 C  CB  . PHE C 1 197 ? -54     22.993  27.823  1    45.28  ? 193 PHE C CB  1 
ATOM   6118 C  CG  . PHE C 1 197 ? -54.694 23.683  26.662  1    45.25  ? 193 PHE C CG  1 
ATOM   6119 C  CD1 . PHE C 1 197 ? -54.104 24.748  25.991  1    47.1   ? 193 PHE C CD1 1 
ATOM   6120 C  CD2 . PHE C 1 197 ? -55.933 23.237  26.22   1    46.56  ? 193 PHE C CD2 1 
ATOM   6121 C  CE1 . PHE C 1 197 ? -54.76  25.367  24.921  1    52.96  ? 193 PHE C CE1 1 
ATOM   6122 C  CE2 . PHE C 1 197 ? -56.584 23.869  25.155  1    49.26  ? 193 PHE C CE2 1 
ATOM   6123 C  CZ  . PHE C 1 197 ? -56     24.924  24.498  1    50.14  ? 193 PHE C CZ  1 
ATOM   6124 N  N   . ALA C 1 198 ? -53.77  25.052  30.175  1    47.91  ? 194 ALA C N   1 
ATOM   6125 C  CA  . ALA C 1 198 ? -54.231 26.28   30.802  1    48.25  ? 194 ALA C CA  1 
ATOM   6126 C  C   . ALA C 1 198 ? -53.036 27.149  31.17   1    51.36  ? 194 ALA C C   1 
ATOM   6127 O  O   . ALA C 1 198 ? -53.097 28.379  31.058  1    54.6   ? 194 ALA C O   1 
ATOM   6128 C  CB  . ALA C 1 198 ? -55.057 25.97   32.03   1    47.42  ? 194 ALA C CB  1 
ATOM   6129 N  N   . GLU C 1 199 ? -51.963 26.489  31.611  1    48.77  ? 195 GLU C N   1 
ATOM   6130 C  CA  . GLU C 1 199 ? -50.797 27.169  32.15   1    50.31  ? 195 GLU C CA  1 
ATOM   6131 C  C   . GLU C 1 199 ? -50.059 27.871  31.01   1    52.44  ? 195 GLU C C   1 
ATOM   6132 O  O   . GLU C 1 199 ? -49.572 28.991  31.194  1    56.27  ? 195 GLU C O   1 
ATOM   6133 C  CB  . GLU C 1 199 ? -49.945 26.181  32.949  1    46.87  ? 195 GLU C CB  1 
ATOM   6134 C  CG  . GLU C 1 199 ? -48.819 26.81   33.758  1    45.57  ? 195 GLU C CG  1 
ATOM   6135 C  CD  . GLU C 1 199 ? -48.119 25.887  34.744  1    47.11  ? 195 GLU C CD  1 
ATOM   6136 O  OE1 . GLU C 1 199 ? -48.672 24.817  35.075  1    44.5   ? 195 GLU C OE1 1 
ATOM   6137 O  OE2 . GLU C 1 199 ? -46.984 26.237  35.18   1    51.39  ? 195 GLU C OE2 1 
ATOM   6138 N  N   . MET C 1 200 ? -49.996 27.231  29.834  1    48.77  ? 196 MET C N   1 
ATOM   6139 C  CA  . MET C 1 200 ? -49.364 27.841  28.674  1    48.96  ? 196 MET C CA  1 
ATOM   6140 C  C   . MET C 1 200 ? -50.091 29.138  28.293  1    55.56  ? 196 MET C C   1 
ATOM   6141 O  O   . MET C 1 200 ? -49.449 30.15   28.009  1    59.47  ? 196 MET C O   1 
ATOM   6142 C  CB  . MET C 1 200 ? -49.339 26.873  27.491  1    45.42  ? 196 MET C CB  1 
ATOM   6143 C  CG  . MET C 1 200 ? -48.183 25.902  27.542  1    45.13  ? 196 MET C CG  1 
ATOM   6144 S  SD  . MET C 1 200 ? -47.932 24.915  26.046  1    50.5   ? 196 MET C SD  1 
ATOM   6145 C  CE  . MET C 1 200 ? -49.399 23.881  25.952  1    41.31  ? 196 MET C CE  1 
ATOM   6146 N  N   . VAL C 1 201 ? -51.432 29.122  28.344  1    52.56  ? 197 VAL C N   1 
ATOM   6147 C  CA  . VAL C 1 201 ? -52.233 30.273  27.976  1    55.88  ? 197 VAL C CA  1 
ATOM   6148 C  C   . VAL C 1 201 ? -52.055 31.452  28.947  1    60.35  ? 197 VAL C C   1 
ATOM   6149 O  O   . VAL C 1 201 ? -51.905 32.583  28.473  1    65.14  ? 197 VAL C O   1 
ATOM   6150 C  CB  . VAL C 1 201 ? -53.706 29.855  27.846  1    54.92  ? 197 VAL C CB  1 
ATOM   6151 C  CG1 . VAL C 1 201 ? -54.623 31.06   27.72   1    53.34  ? 197 VAL C CG1 1 
ATOM   6152 C  CG2 . VAL C 1 201 ? -53.9   28.895  26.683  1    52.11  ? 197 VAL C CG2 1 
ATOM   6153 N  N   . THR C 1 202 ? -52.05  31.189  30.272  1    56.34  ? 198 THR C N   1 
ATOM   6154 C  CA  . THR C 1 202 ? -51.998 32.219  31.317  1    54.07  ? 198 THR C CA  1 
ATOM   6155 C  C   . THR C 1 202 ? -50.597 32.362  31.923  1    54.93  ? 198 THR C C   1 
ATOM   6156 O  O   . THR C 1 202 ? -50.36  33.292  32.693  1    53.21  ? 198 THR C O   1 
ATOM   6157 C  CB  . THR C 1 202 ? -52.962 31.951  32.473  1    52.86  ? 198 THR C CB  1 
ATOM   6158 O  OG1 . THR C 1 202 ? -52.48  30.769  33.101  1    55.14  ? 198 THR C OG1 1 
ATOM   6159 C  CG2 . THR C 1 202 ? -54.396 31.708  32.071  1    53.92  ? 198 THR C CG2 1 
ATOM   6160 N  N   . ARG C 1 203 ? -49.7   31.392  31.668  1    56.35  ? 199 ARG C N   1 
ATOM   6161 C  CA  . ARG C 1 203 ? -48.361 31.35   32.259  1    62.79  ? 199 ARG C CA  1 
ATOM   6162 C  C   . ARG C 1 203 ? -48.387 31.283  33.797  1    65.27  ? 199 ARG C C   1 
ATOM   6163 O  O   . ARG C 1 203 ? -47.367 31.522  34.444  1    65.66  ? 199 ARG C O   1 
ATOM   6164 C  CB  . ARG C 1 203 ? -47.5   32.527  31.791  1    67.26  ? 199 ARG C CB  1 
ATOM   6165 C  CG  . ARG C 1 203 ? -46.703 32.332  30.509  1    64.37  ? 199 ARG C CG  1 
ATOM   6166 C  CD  . ARG C 1 203 ? -46.548 33.723  29.882  1    78.77  ? 199 ARG C CD  1 
ATOM   6167 N  NE  . ARG C 1 203 ? -47.89  34.063  29.399  1    86.31  ? 199 ARG C NE  1 
ATOM   6168 C  CZ  . ARG C 1 203 ? -48.469 35.256  29.508  1    81.79  ? 199 ARG C CZ  1 
ATOM   6169 N  NH1 . ARG C 1 203 ? -47.765 36.289  29.933  1    70.19  ? 199 ARG C NH1 1 
ATOM   6170 N  NH2 . ARG C 1 203 ? -49.754 35.377  29.186  1    83.94  ? 199 ARG C NH2 1 
ATOM   6171 N  N   . ARG C 1 204 ? -49.547 30.958  34.38   1    66.26  ? 200 ARG C N   1 
ATOM   6172 C  CA  . ARG C 1 204 ? -49.717 30.657  35.795  1    61.59  ? 200 ARG C CA  1 
ATOM   6173 C  C   . ARG C 1 204 ? -50.352 29.279  35.879  1    61.71  ? 200 ARG C C   1 
ATOM   6174 O  O   . ARG C 1 204 ? -51.21  28.952  35.054  1    62.52  ? 200 ARG C O   1 
ATOM   6175 C  CB  . ARG C 1 204 ? -50.671 31.643  36.484  1    60.76  ? 200 ARG C CB  1 
ATOM   6176 C  CG  . ARG C 1 204 ? -50.105 33.047  36.529  1    69.66  ? 200 ARG C CG  1 
ATOM   6177 C  CD  . ARG C 1 204 ? -51.094 34.096  37.05   1    78.6   ? 200 ARG C CD  1 
ATOM   6178 N  NE  . ARG C 1 204 ? -51.744 34.804  35.938  1    86.45  ? 200 ARG C NE  1 
ATOM   6179 C  CZ  . ARG C 1 204 ? -51.606 36.093  35.582  1    89.9   ? 200 ARG C CZ  1 
ATOM   6180 N  NH1 . ARG C 1 204 ? -50.878 36.925  36.298  1    96.34  ? 200 ARG C NH1 1 
ATOM   6181 N  NH2 . ARG C 1 204 ? -52.179 36.566  34.491  1    89     ? 200 ARG C NH2 1 
ATOM   6182 N  N   . ALA C 1 205 ? -49.927 28.499  36.881  1    57.62  ? 201 ALA C N   1 
ATOM   6183 C  CA  . ALA C 1 205 ? -50.516 27.205  37.192  1    52.73  ? 201 ALA C CA  1 
ATOM   6184 C  C   . ALA C 1 205 ? -52.023 27.37   37.382  1    51.48  ? 201 ALA C C   1 
ATOM   6185 O  O   . ALA C 1 205 ? -52.464 28.397  37.87   1    52.27  ? 201 ALA C O   1 
ATOM   6186 C  CB  . ALA C 1 205 ? -49.838 26.655  38.436  1    54.41  ? 201 ALA C CB  1 
ATOM   6187 N  N   . LEU C 1 206 ? -52.807 26.362  36.99   1    49.45  ? 202 LEU C N   1 
ATOM   6188 C  CA  . LEU C 1 206 ? -54.261 26.442  37.035  1    47.62  ? 202 LEU C CA  1 
ATOM   6189 C  C   . LEU C 1 206 ? -54.778 26.149  38.439  1    49.28  ? 202 LEU C C   1 
ATOM   6190 O  O   . LEU C 1 206 ? -55.725 26.793  38.858  1    51.53  ? 202 LEU C O   1 
ATOM   6191 C  CB  . LEU C 1 206 ? -54.858 25.459  36.026  1    45.11  ? 202 LEU C CB  1 
ATOM   6192 C  CG  . LEU C 1 206 ? -56.385 25.338  36.007  1    46.03  ? 202 LEU C CG  1 
ATOM   6193 C  CD1 . LEU C 1 206 ? -57.053 26.681  35.659  1    43.95  ? 202 LEU C CD1 1 
ATOM   6194 C  CD2 . LEU C 1 206 ? -56.813 24.21   35.064  1    43.13  ? 202 LEU C CD2 1 
ATOM   6195 N  N   . PHE C 1 207 ? -54.18  25.164  39.131  1    47.49  ? 203 PHE C N   1 
ATOM   6196 C  CA  . PHE C 1 207 ? -54.586 24.78   40.477  1    49.94  ? 203 PHE C CA  1 
ATOM   6197 C  C   . PHE C 1 207 ? -53.375 24.665  41.413  1    51.73  ? 203 PHE C C   1 
ATOM   6198 O  O   . PHE C 1 207 ? -52.872 23.567  41.666  1    52.54  ? 203 PHE C O   1 
ATOM   6199 C  CB  . PHE C 1 207 ? -55.25  23.398  40.426  1    48.26  ? 203 PHE C CB  1 
ATOM   6200 C  CG  . PHE C 1 207 ? -56.448 23.305  39.503  1    47.95  ? 203 PHE C CG  1 
ATOM   6201 C  CD1 . PHE C 1 207 ? -57.5   24.203  39.606  1    49.61  ? 203 PHE C CD1 1 
ATOM   6202 C  CD2 . PHE C 1 207 ? -56.51  22.324  38.529  1    46.47  ? 203 PHE C CD2 1 
ATOM   6203 C  CE1 . PHE C 1 207 ? -58.592 24.12   38.755  1    49.4   ? 203 PHE C CE1 1 
ATOM   6204 C  CE2 . PHE C 1 207 ? -57.604 22.247  37.677  1    48.17  ? 203 PHE C CE2 1 
ATOM   6205 C  CZ  . PHE C 1 207 ? -58.649 23.142  37.797  1    48.95  ? 203 PHE C CZ  1 
ATOM   6206 N  N   . PRO C 1 208 ? -52.843 25.782  41.954  1    52.06  ? 204 PRO C N   1 
ATOM   6207 C  CA  . PRO C 1 208 ? -51.655 25.716  42.808  1    53.79  ? 204 PRO C CA  1 
ATOM   6208 C  C   . PRO C 1 208 ? -51.965 25.485  44.289  1    57.63  ? 204 PRO C C   1 
ATOM   6209 O  O   . PRO C 1 208 ? -51.779 26.381  45.112  1    66.45  ? 204 PRO C O   1 
ATOM   6210 C  CB  . PRO C 1 208 ? -51.07  27.122  42.538  1    51.72  ? 204 PRO C CB  1 
ATOM   6211 C  CG  . PRO C 1 208 ? -52.291 28.015  42.461  1    50.35  ? 204 PRO C CG  1 
ATOM   6212 C  CD  . PRO C 1 208 ? -53.324 27.158  41.741  1    51.34  ? 204 PRO C CD  1 
ATOM   6213 N  N   . GLY C 1 209 ? -52.327 24.251  44.624  1    54.55  ? 205 GLY C N   1 
ATOM   6214 C  CA  . GLY C 1 209 ? -52.694 23.906  46.004  1    53.21  ? 205 GLY C CA  1 
ATOM   6215 C  C   . GLY C 1 209 ? -51.52  23.733  46.934  1    51.97  ? 205 GLY C C   1 
ATOM   6216 O  O   . GLY C 1 209 ? -50.44  23.351  46.468  1    54.69  ? 205 GLY C O   1 
ATOM   6217 N  N   . ASP C 1 210 ? -51.741 23.997  48.218  1    59.87  ? 206 ASP C N   1 
ATOM   6218 C  CA  . ASP C 1 210 ? -50.677 23.87   49.245  1    65.07  ? 206 ASP C CA  1 
ATOM   6219 C  C   . ASP C 1 210 ? -50.933 22.59   50.036  1    65.7   ? 206 ASP C C   1 
ATOM   6220 O  O   . ASP C 1 210 ? -50.123 22.275  50.915  1    74.63  ? 206 ASP C O   1 
ATOM   6221 C  CB  . ASP C 1 210 ? -50.631 25.118  50.108  1    69.02  ? 206 ASP C CB  1 
ATOM   6222 C  CG  . ASP C 1 210 ? -50.097 26.377  49.444  1    78.82  ? 206 ASP C CG  1 
ATOM   6223 O  OD1 . ASP C 1 210 ? -49.479 26.258  48.368  1    88.56  ? 206 ASP C OD1 1 
ATOM   6224 O  OD2 . ASP C 1 210 ? -50.292 27.465  50.017  1    80.14  ? 206 ASP C OD2 1 
ATOM   6225 N  N   . SER C 1 211 ? -52.015 21.887  49.718  1    66.14  ? 207 SER C N   1 
ATOM   6226 C  CA  . SER C 1 211 ? -52.374 20.614  50.387  1    63.62  ? 207 SER C CA  1 
ATOM   6227 C  C   . SER C 1 211 ? -53.314 19.847  49.451  1    65.21  ? 207 SER C C   1 
ATOM   6228 O  O   . SER C 1 211 ? -53.702 20.415  48.419  1    71.28  ? 207 SER C O   1 
ATOM   6229 C  CB  . SER C 1 211 ? -53.034 20.865  51.696  1    64.11  ? 207 SER C CB  1 
ATOM   6230 O  OG  . SER C 1 211 ? -54.429 21.057  51.525  1    62.59  ? 207 SER C OG  1 
ATOM   6231 N  N   . GLU C 1 212 ? -53.678 18.622  49.813  1    61.51  ? 208 GLU C N   1 
ATOM   6232 C  CA  . GLU C 1 212 ? -54.586 17.808  48.972  1    61.29  ? 208 GLU C CA  1 
ATOM   6233 C  C   . GLU C 1 212 ? -56.015 18.351  49.095  1    61.53  ? 208 GLU C C   1 
ATOM   6234 O  O   . GLU C 1 212 ? -56.727 18.384  48.08   1    56.32  ? 208 GLU C O   1 
ATOM   6235 C  CB  . GLU C 1 212 ? -54.464 16.351  49.407  1    64.43  ? 208 GLU C CB  1 
ATOM   6236 C  CG  . GLU C 1 212 ? -53.252 15.647  48.809  1    75.54  ? 208 GLU C CG  1 
ATOM   6237 C  CD  . GLU C 1 212 ? -53.036 14.252  49.362  1    82.63  ? 208 GLU C CD  1 
ATOM   6238 O  OE1 . GLU C 1 212 ? -53.834 13.357  49.025  1    82.61  ? 208 GLU C OE1 1 
ATOM   6239 O  OE2 . GLU C 1 212 ? -52.072 14.062  50.129  1    86.31  ? 208 GLU C OE2 1 
ATOM   6240 N  N   . ILE C 1 213 ? -56.403 18.768  50.299  1    64.15  ? 209 ILE C N   1 
ATOM   6241 C  CA  . ILE C 1 213 ? -57.761 19.348  50.51   1    62.44  ? 209 ILE C CA  1 
ATOM   6242 C  C   . ILE C 1 213 ? -57.805 20.714  49.814  1    61.84  ? 209 ILE C C   1 
ATOM   6243 O  O   . ILE C 1 213 ? -58.849 21.036  49.233  1    65.38  ? 209 ILE C O   1 
ATOM   6244 C  CB  . ILE C 1 213 ? -58.12  19.408  52.008  1    63.08  ? 209 ILE C CB  1 
ATOM   6245 C  CG1 . ILE C 1 213 ? -59.63  19.438  52.219  1    70.95  ? 209 ILE C CG1 1 
ATOM   6246 C  CG2 . ILE C 1 213 ? -57.435 20.572  52.723  1    63.86  ? 209 ILE C CG2 1 
ATOM   6247 C  CD1 . ILE C 1 213 ? -60.397 18.492  51.316  1    74.36  ? 209 ILE C CD1 1 
ATOM   6248 N  N   . ASP C 1 214 ? -56.696 21.449  49.827  1    56.37  ? 210 ASP C N   1 
ATOM   6249 C  CA  . ASP C 1 214 ? -56.655 22.742  49.103  1    58.07  ? 210 ASP C CA  1 
ATOM   6250 C  C   . ASP C 1 214 ? -56.735 22.444  47.608  1    55.84  ? 210 ASP C C   1 
ATOM   6251 O  O   . ASP C 1 214 ? -57.461 23.151  46.898  1    55.16  ? 210 ASP C O   1 
ATOM   6252 C  CB  . ASP C 1 214 ? -55.437 23.57   49.477  1    59.93  ? 210 ASP C CB  1 
ATOM   6253 C  CG  . ASP C 1 214 ? -55.407 24.974  48.901  1    62.81  ? 210 ASP C CG  1 
ATOM   6254 O  OD1 . ASP C 1 214 ? -56.39  25.709  49.106  1    64.21  ? 210 ASP C OD1 1 
ATOM   6255 O  OD2 . ASP C 1 214 ? -54.403 25.314  48.252  1    61.96  ? 210 ASP C OD2 1 
ATOM   6256 N  N   . GLN C 1 215 ? -56.02  21.412  47.17   1    54.61  ? 211 GLN C N   1 
ATOM   6257 C  CA  . GLN C 1 215 ? -56.026 21.091  45.747  1    56.2   ? 211 GLN C CA  1 
ATOM   6258 C  C   . GLN C 1 215 ? -57.442 20.787  45.251  1    57.83  ? 211 GLN C C   1 
ATOM   6259 O  O   . GLN C 1 215 ? -57.838 21.25   44.183  1    58.63  ? 211 GLN C O   1 
ATOM   6260 C  CB  . GLN C 1 215 ? -55.105 19.904  45.489  1    56.69  ? 211 GLN C CB  1 
ATOM   6261 C  CG  . GLN C 1 215 ? -54.823 19.611  44.016  1    60.64  ? 211 GLN C CG  1 
ATOM   6262 C  CD  . GLN C 1 215 ? -54.016 20.681  43.311  1    59.77  ? 211 GLN C CD  1 
ATOM   6263 O  OE1 . GLN C 1 215 ? -53.196 21.388  43.912  1    59.46  ? 211 GLN C OE1 1 
ATOM   6264 N  NE2 . GLN C 1 215 ? -54.264 20.823  42.022  1    56.33  ? 211 GLN C NE2 1 
ATOM   6265 N  N   . LEU C 1 216 ? -58.219 20.055  46.061  1    61.03  ? 212 LEU C N   1 
ATOM   6266 C  CA  . LEU C 1 216 ? -59.606 19.744  45.745  1    59.04  ? 212 LEU C CA  1 
ATOM   6267 C  C   . LEU C 1 216 ? -60.475 21.002  45.691  1    59.25  ? 212 LEU C C   1 
ATOM   6268 O  O   . LEU C 1 216 ? -61.28  21.183  44.77   1    55.98  ? 212 LEU C O   1 
ATOM   6269 C  CB  . LEU C 1 216 ? -60.139 18.755  46.775  1    59.87  ? 212 LEU C CB  1 
ATOM   6270 C  CG  . LEU C 1 216 ? -59.797 17.298  46.472  1    63.06  ? 212 LEU C CG  1 
ATOM   6271 C  CD1 . LEU C 1 216 ? -60.214 16.398  47.609  1    65.32  ? 212 LEU C CD1 1 
ATOM   6272 C  CD2 . LEU C 1 216 ? -60.441 16.848  45.144  1    60.6   ? 212 LEU C CD2 1 
ATOM   6273 N  N   . PHE C 1 217 ? -60.335 21.848  46.72   1    58.5   ? 213 PHE C N   1 
ATOM   6274 C  CA  . PHE C 1 217 ? -61.126 23.063  46.802  1    59.29  ? 213 PHE C CA  1 
ATOM   6275 C  C   . PHE C 1 217 ? -60.795 23.99   45.625  1    60.23  ? 213 PHE C C   1 
ATOM   6276 O  O   . PHE C 1 217 ? -61.681 24.68   45.119  1    62.92  ? 213 PHE C O   1 
ATOM   6277 C  CB  . PHE C 1 217 ? -60.974 23.732  48.176  1    60.11  ? 213 PHE C CB  1 
ATOM   6278 C  CG  . PHE C 1 217 ? -61.495 22.972  49.392  1    60.36  ? 213 PHE C CG  1 
ATOM   6279 C  CD1 . PHE C 1 217 ? -62.204 21.782  49.276  1    61.59  ? 213 PHE C CD1 1 
ATOM   6280 C  CD2 . PHE C 1 217 ? -61.255 23.454  50.667  1    60.19  ? 213 PHE C CD2 1 
ATOM   6281 C  CE1 . PHE C 1 217 ? -62.646 21.109  50.403  1    61.84  ? 213 PHE C CE1 1 
ATOM   6282 C  CE2 . PHE C 1 217 ? -61.708 22.781  51.788  1    61.47  ? 213 PHE C CE2 1 
ATOM   6283 C  CZ  . PHE C 1 217 ? -62.413 21.62   51.658  1    62.03  ? 213 PHE C CZ  1 
ATOM   6284 N  N   . ARG C 1 218 ? -59.521 24.013  45.193  1    56.99  ? 214 ARG C N   1 
ATOM   6285 C  CA  . ARG C 1 218 ? -59.129 24.858  44.077  1    57.38  ? 214 ARG C CA  1 
ATOM   6286 C  C   . ARG C 1 218 ? -59.786 24.384  42.78   1    56.17  ? 214 ARG C C   1 
ATOM   6287 O  O   . ARG C 1 218 ? -60.21  25.19   41.952  1    59.2   ? 214 ARG C O   1 
ATOM   6288 C  CB  . ARG C 1 218 ? -57.606 24.862  43.917  1    54.22  ? 214 ARG C CB  1 
ATOM   6289 C  CG  . ARG C 1 218 ? -56.97  25.92   44.809  1    55.16  ? 214 ARG C CG  1 
ATOM   6290 C  CD  . ARG C 1 218 ? -55.46  25.721  44.888  1    55.37  ? 214 ARG C CD  1 
ATOM   6291 N  NE  . ARG C 1 218 ? -54.976 26.611  45.945  1    59.85  ? 214 ARG C NE  1 
ATOM   6292 C  CZ  . ARG C 1 218 ? -54.808 27.897  45.77   1    58.87  ? 214 ARG C CZ  1 
ATOM   6293 N  NH1 . ARG C 1 218 ? -54.985 28.41   44.566  1    58.53  ? 214 ARG C NH1 1 
ATOM   6294 N  NH2 . ARG C 1 218 ? -54.428 28.617  46.801  1    59.71  ? 214 ARG C NH2 1 
ATOM   6295 N  N   . ILE C 1 219 ? -59.844 23.065  42.617  1    52.7   ? 215 ILE C N   1 
ATOM   6296 C  CA  . ILE C 1 219 ? -60.496 22.457  41.474  1    55.13  ? 215 ILE C CA  1 
ATOM   6297 C  C   . ILE C 1 219 ? -62.013 22.753  41.517  1    60.77  ? 215 ILE C C   1 
ATOM   6298 O  O   . ILE C 1 219 ? -62.582 23.327  40.572  1    61.48  ? 215 ILE C O   1 
ATOM   6299 C  CB  . ILE C 1 219 ? -60.154 20.952  41.439  1    49.28  ? 215 ILE C CB  1 
ATOM   6300 C  CG1 . ILE C 1 219 ? -58.652 20.722  41.188  1    43.52  ? 215 ILE C CG1 1 
ATOM   6301 C  CG2 . ILE C 1 219 ? -61.05  20.231  40.428  1    48.07  ? 215 ILE C CG2 1 
ATOM   6302 C  CD1 . ILE C 1 219 ? -58.17  19.282  41.401  1    41.89  ? 215 ILE C CD1 1 
ATOM   6303 N  N   . PHE C 1 220 ? -62.654 22.383  42.64   1    59.6   ? 216 PHE C N   1 
ATOM   6304 C  CA  . PHE C 1 220 ? -64.093 22.481  42.813  1    59.37  ? 216 PHE C CA  1 
ATOM   6305 C  C   . PHE C 1 220 ? -64.6   23.886  42.524  1    62.58  ? 216 PHE C C   1 
ATOM   6306 O  O   . PHE C 1 220 ? -65.611 24.06   41.855  1    66.78  ? 216 PHE C O   1 
ATOM   6307 C  CB  . PHE C 1 220 ? -64.467 22.036  44.221  1    58.6   ? 216 PHE C CB  1 
ATOM   6308 C  CG  . PHE C 1 220 ? -64.336 20.548  44.482  1    61.02  ? 216 PHE C CG  1 
ATOM   6309 C  CD1 . PHE C 1 220 ? -63.921 19.664  43.491  1    58.45  ? 216 PHE C CD1 1 
ATOM   6310 C  CD2 . PHE C 1 220 ? -64.656 20.037  45.736  1    64.83  ? 216 PHE C CD2 1 
ATOM   6311 C  CE1 . PHE C 1 220 ? -63.815 18.314  43.76   1    60.02  ? 216 PHE C CE1 1 
ATOM   6312 C  CE2 . PHE C 1 220 ? -64.544 18.679  45.998  1    64.99  ? 216 PHE C CE2 1 
ATOM   6313 C  CZ  . PHE C 1 220 ? -64.124 17.821  45.007  1    61.74  ? 216 PHE C CZ  1 
ATOM   6314 N  N   . ARG C 1 221 ? -63.914 24.897  43.064  1    66     ? 217 ARG C N   1 
ATOM   6315 C  CA  . ARG C 1 221 ? -64.383 26.298  42.9    1    73.55  ? 217 ARG C CA  1 
ATOM   6316 C  C   . ARG C 1 221 ? -64.347 26.713  41.428  1    74.33  ? 217 ARG C C   1 
ATOM   6317 O  O   . ARG C 1 221 ? -65.139 27.6    41.05   1    81.21  ? 217 ARG C O   1 
ATOM   6318 C  CB  . ARG C 1 221 ? -63.458 27.275  43.63   1    71.95  ? 217 ARG C CB  1 
ATOM   6319 C  CG  . ARG C 1 221 ? -63.536 27.251  45.147  1    72.17  ? 217 ARG C CG  1 
ATOM   6320 C  CD  . ARG C 1 221 ? -62.371 27.985  45.784  1    78.82  ? 217 ARG C CD  1 
ATOM   6321 N  NE  . ARG C 1 221 ? -62.747 28.568  47.076  1    77.85  ? 217 ARG C NE  1 
ATOM   6322 C  CZ  . ARG C 1 221 ? -62.436 28.041  48.252  1    81.41  ? 217 ARG C CZ  1 
ATOM   6323 N  NH1 . ARG C 1 221 ? -62.988 28.515  49.355  1    90.52  ? 217 ARG C NH1 1 
ATOM   6324 N  NH2 . ARG C 1 221 ? -61.579 27.039  48.321  1    80.61  ? 217 ARG C NH2 1 
ATOM   6325 N  N   . THR C 1 222 ? -63.475 26.096  40.631  1    71.45  ? 218 THR C N   1 
ATOM   6326 C  CA  . THR C 1 222 ? -63.288 26.52   39.245  1    71.82  ? 218 THR C CA  1 
ATOM   6327 C  C   . THR C 1 222 ? -64.194 25.718  38.307  1    71.92  ? 218 THR C C   1 
ATOM   6328 O  O   . THR C 1 222 ? -64.661 26.262  37.306  1    77.88  ? 218 THR C O   1 
ATOM   6329 C  CB  . THR C 1 222 ? -61.801 26.414  38.879  1    72.7   ? 218 THR C CB  1 
ATOM   6330 O  OG1 . THR C 1 222 ? -61.149 27.516  39.505  1    67.56  ? 218 THR C OG1 1 
ATOM   6331 C  CG2 . THR C 1 222 ? -61.517 26.474  37.386  1    73.17  ? 218 THR C CG2 1 
ATOM   6332 N  N   . LEU C 1 223 ? -64.445 24.439  38.632  1    68.7   ? 219 LEU C N   1 
ATOM   6333 C  CA  . LEU C 1 223 ? -65.225 23.559  37.758  1    74.17  ? 219 LEU C CA  1 
ATOM   6334 C  C   . LEU C 1 223 ? -66.591 23.199  38.332  1    79.16  ? 219 LEU C C   1 
ATOM   6335 O  O   . LEU C 1 223 ? -67.403 22.623  37.614  1    83.56  ? 219 LEU C O   1 
ATOM   6336 C  CB  . LEU C 1 223 ? -64.469 22.266  37.462  1    74.1   ? 219 LEU C CB  1 
ATOM   6337 C  CG  . LEU C 1 223 ? -63.029 22.396  36.948  1    69.77  ? 219 LEU C CG  1 
ATOM   6338 C  CD1 . LEU C 1 223 ? -62.359 21.048  36.985  1    63.48  ? 219 LEU C CD1 1 
ATOM   6339 C  CD2 . LEU C 1 223 ? -62.959 22.986  35.549  1    64.15  ? 219 LEU C CD2 1 
ATOM   6340 N  N   . GLY C 1 224 ? -66.812 23.487  39.619  1    79.92  ? 220 GLY C N   1 
ATOM   6341 C  CA  . GLY C 1 224 ? -68.058 23.163  40.296  1    77.25  ? 220 GLY C CA  1 
ATOM   6342 C  C   . GLY C 1 224 ? -67.87  21.912  41.139  1    77.32  ? 220 GLY C C   1 
ATOM   6343 O  O   . GLY C 1 224 ? -67.28  20.947  40.673  1    79.87  ? 220 GLY C O   1 
ATOM   6344 N  N   . THR C 1 225 ? -68.332 21.951  42.392  1    80.79  ? 221 THR C N   1 
ATOM   6345 C  CA  . THR C 1 225 ? -68.235 20.759  43.219  1    83.03  ? 221 THR C CA  1 
ATOM   6346 C  C   . THR C 1 225 ? -68.976 19.652  42.464  1    85.2   ? 221 THR C C   1 
ATOM   6347 O  O   . THR C 1 225 ? -70.165 19.786  42.177  1    88.25  ? 221 THR C O   1 
ATOM   6348 C  CB  . THR C 1 225 ? -68.781 21.004  44.635  1    80.88  ? 221 THR C CB  1 
ATOM   6349 O  OG1 . THR C 1 225 ? -68.211 22.232  45.099  1    75.47  ? 221 THR C OG1 1 
ATOM   6350 C  CG2 . THR C 1 225 ? -68.428 19.873  45.586  1    78.4   ? 221 THR C CG2 1 
ATOM   6351 N  N   . PRO C 1 226 ? -68.294 18.552  42.075  1    86.02  ? 222 PRO C N   1 
ATOM   6352 C  CA  . PRO C 1 226 ? -68.926 17.504  41.26   1    92.21  ? 222 PRO C CA  1 
ATOM   6353 C  C   . PRO C 1 226 ? -70.121 16.861  41.965  1    95.51  ? 222 PRO C C   1 
ATOM   6354 O  O   . PRO C 1 226 ? -70.173 16.872  43.19   1    91.47  ? 222 PRO C O   1 
ATOM   6355 C  CB  . PRO C 1 226 ? -67.771 16.49   41.039  1    94.91  ? 222 PRO C CB  1 
ATOM   6356 C  CG  . PRO C 1 226 ? -66.801 16.752  42.189  1    86.63  ? 222 PRO C CG  1 
ATOM   6357 C  CD  . PRO C 1 226 ? -66.893 18.252  42.431  1    84.55  ? 222 PRO C CD  1 
ATOM   6358 N  N   . ASP C 1 227 ? -71.068 16.304  41.191  1    99.76  ? 223 ASP C N   1 
ATOM   6359 C  CA  . ASP C 1 227 ? -72.224 15.599  41.74   1    94.57  ? 223 ASP C CA  1 
ATOM   6360 C  C   . ASP C 1 227 ? -72.372 14.257  41.019  1    92.01  ? 223 ASP C C   1 
ATOM   6361 O  O   . ASP C 1 227 ? -71.68  14.002  40.031  1    87.86  ? 223 ASP C O   1 
ATOM   6362 C  CB  . ASP C 1 227 ? -73.496 16.431  41.626  1    93.63  ? 223 ASP C CB  1 
ATOM   6363 C  CG  . ASP C 1 227 ? -73.942 16.754  40.198  1    103.86 ? 223 ASP C CG  1 
ATOM   6364 O  OD1 . ASP C 1 227 ? -73.213 16.379  39.243  1    112.84 ? 223 ASP C OD1 1 
ATOM   6365 O  OD2 . ASP C 1 227 ? -74.999 17.395  40.043  1    108.49 ? 223 ASP C OD2 1 
ATOM   6366 N  N   . GLU C 1 228 ? -73.329 13.446  41.458  1    97.5   ? 224 GLU C N   1 
ATOM   6367 C  CA  . GLU C 1 228 ? -73.504 12.1    40.863  1    97.1   ? 224 GLU C CA  1 
ATOM   6368 C  C   . GLU C 1 228 ? -74.066 12.227  39.443  1    104.41 ? 224 GLU C C   1 
ATOM   6369 O  O   . GLU C 1 228 ? -74.395 11.187  38.849  1    117.26 ? 224 GLU C O   1 
ATOM   6370 C  CB  . GLU C 1 228 ? -74.428 11.28   41.755  1    95.14  ? 224 GLU C CB  1 
ATOM   6371 C  CG  . GLU C 1 228 ? -73.76  10.828  43.047  1    98.55  ? 224 GLU C CG  1 
ATOM   6372 C  CD  . GLU C 1 228 ? -72.847 9.641   42.829  1    99.75  ? 224 GLU C CD  1 
ATOM   6373 O  OE1 . GLU C 1 228 ? -73.2   8.773   42.007  1    99.3   ? 224 GLU C OE1 1 
ATOM   6374 O  OE2 . GLU C 1 228 ? -71.785 9.586   43.476  1    102.12 ? 224 GLU C OE2 1 
ATOM   6375 N  N   . VAL C 1 229 ? -74.164 13.449  38.925  1    104.59 ? 225 VAL C N   1 
ATOM   6376 C  CA  . VAL C 1 229 ? -74.655 13.663  37.534  1    97.45  ? 225 VAL C CA  1 
ATOM   6377 C  C   . VAL C 1 229 ? -73.446 14.006  36.659  1    92.52  ? 225 VAL C C   1 
ATOM   6378 O  O   . VAL C 1 229 ? -73.431 13.596  35.484  1    92.96  ? 225 VAL C O   1 
ATOM   6379 C  CB  . VAL C 1 229 ? -75.715 14.778  37.503  1    96.21  ? 225 VAL C CB  1 
ATOM   6380 C  CG1 . VAL C 1 229 ? -76.36  14.922  36.131  1    91.26  ? 225 VAL C CG1 1 
ATOM   6381 C  CG2 . VAL C 1 229 ? -76.774 14.577  38.578  1    95.67  ? 225 VAL C CG2 1 
ATOM   6382 N  N   . VAL C 1 230 ? -72.474 14.726  37.216  1    94.75  ? 226 VAL C N   1 
ATOM   6383 C  CA  . VAL C 1 230 ? -71.222 15.037  36.467  1    96.05  ? 226 VAL C CA  1 
ATOM   6384 C  C   . VAL C 1 230 ? -70.293 13.833  36.618  1    100.5  ? 226 VAL C C   1 
ATOM   6385 O  O   . VAL C 1 230 ? -69.709 13.402  35.607  1    100.36 ? 226 VAL C O   1 
ATOM   6386 C  CB  . VAL C 1 230 ? -70.543 16.303  37.017  1    93.6   ? 226 VAL C CB  1 
ATOM   6387 C  CG1 . VAL C 1 230 ? -69.09  16.412  36.583  1    82.18  ? 226 VAL C CG1 1 
ATOM   6388 C  CG2 . VAL C 1 230 ? -71.312 17.565  36.65   1    94.5   ? 226 VAL C CG2 1 
ATOM   6389 N  N   . TRP C 1 231 ? -70.205 13.3    37.834  1    103.68 ? 227 TRP C N   1 
ATOM   6390 C  CA  . TRP C 1 231 ? -69.264 12.19   38.095  1    94.98  ? 227 TRP C CA  1 
ATOM   6391 C  C   . TRP C 1 231 ? -69.971 11.077  38.852  1    97.26  ? 227 TRP C C   1 
ATOM   6392 O  O   . TRP C 1 231 ? -69.674 10.857  40.03   1    101.59 ? 227 TRP C O   1 
ATOM   6393 C  CB  . TRP C 1 231 ? -68.068 12.735  38.88   1    90.3   ? 227 TRP C CB  1 
ATOM   6394 C  CG  . TRP C 1 231 ? -66.864 11.837  38.921  1    89.18  ? 227 TRP C CG  1 
ATOM   6395 C  CD1 . TRP C 1 231 ? -66.767 10.539  38.516  1    85.05  ? 227 TRP C CD1 1 
ATOM   6396 C  CD2 . TRP C 1 231 ? -65.563 12.202  39.421  1    88.12  ? 227 TRP C CD2 1 
ATOM   6397 N  NE1 . TRP C 1 231 ? -65.5   10.072  38.73   1    84.71  ? 227 TRP C NE1 1 
ATOM   6398 C  CE2 . TRP C 1 231 ? -64.738 11.068  39.28   1    87.67  ? 227 TRP C CE2 1 
ATOM   6399 C  CE3 . TRP C 1 231 ? -65.023 13.369  39.967  1    85.51  ? 227 TRP C CE3 1 
ATOM   6400 C  CZ2 . TRP C 1 231 ? -63.401 11.074  39.665  1    87.62  ? 227 TRP C CZ2 1 
ATOM   6401 C  CZ3 . TRP C 1 231 ? -63.701 13.372  40.349  1    89.43  ? 227 TRP C CZ3 1 
ATOM   6402 C  CH2 . TRP C 1 231 ? -62.904 12.24   40.198  1    95.25  ? 227 TRP C CH2 1 
ATOM   6403 N  N   . PRO C 1 232 ? -70.915 10.354  38.23   1    100.47 ? 228 PRO C N   1 
ATOM   6404 C  CA  . PRO C 1 232 ? -71.518 9.182   38.863  1    101.23 ? 228 PRO C CA  1 
ATOM   6405 C  C   . PRO C 1 232 ? -70.476 8.391   39.654  1    95.64  ? 228 PRO C C   1 
ATOM   6406 O  O   . PRO C 1 232 ? -69.481 7.937   39.086  1    90.8   ? 228 PRO C O   1 
ATOM   6407 C  CB  . PRO C 1 232 ? -72.008 8.373   37.641  1    100.77 ? 228 PRO C CB  1 
ATOM   6408 C  CG  . PRO C 1 232 ? -72.327 9.402   36.59   1    97.88  ? 228 PRO C CG  1 
ATOM   6409 C  CD  . PRO C 1 232 ? -71.408 10.582  36.864  1    102.44 ? 228 PRO C CD  1 
ATOM   6410 N  N   . GLY C 1 233 ? -70.713 8.243   40.963  1    93.04  ? 229 GLY C N   1 
ATOM   6411 C  CA  . GLY C 1 233 ? -69.816 7.502   41.838  1    92.94  ? 229 GLY C CA  1 
ATOM   6412 C  C   . GLY C 1 233 ? -68.929 8.4     42.709  1    94.11  ? 229 GLY C C   1 
ATOM   6413 O  O   . GLY C 1 233 ? -68.395 7.938   43.724  1    99.3   ? 229 GLY C O   1 
ATOM   6414 N  N   . VAL C 1 234 ? -68.8   9.681   42.323  1    86.81  ? 230 VAL C N   1 
ATOM   6415 C  CA  . VAL C 1 234 ? -67.993 10.648  43.055  1    83.55  ? 230 VAL C CA  1 
ATOM   6416 C  C   . VAL C 1 234 ? -68.275 10.557  44.563  1    90.53  ? 230 VAL C C   1 
ATOM   6417 O  O   . VAL C 1 234 ? -67.338 10.543  45.366  1    92.87  ? 230 VAL C O   1 
ATOM   6418 C  CB  . VAL C 1 234 ? -68.153 12.094  42.536  1    79.85  ? 230 VAL C CB  1 
ATOM   6419 C  CG1 . VAL C 1 234 ? -69.588 12.595  42.628  1    84.47  ? 230 VAL C CG1 1 
ATOM   6420 C  CG2 . VAL C 1 234 ? -67.224 13.076  43.236  1    77.98  ? 230 VAL C CG2 1 
ATOM   6421 N  N   . THR C 1 235 ? -69.561 10.48   44.947  1    87.53  ? 231 THR C N   1 
ATOM   6422 C  CA  . THR C 1 235 ? -69.963 10.584  46.346  1    93.18  ? 231 THR C CA  1 
ATOM   6423 C  C   . THR C 1 235 ? -69.615 9.308   47.12   1    91.37  ? 231 THR C C   1 
ATOM   6424 O  O   . THR C 1 235 ? -69.737 9.272   48.346  1    89.2   ? 231 THR C O   1 
ATOM   6425 C  CB  . THR C 1 235 ? -71.452 10.927  46.497  1    97.18  ? 231 THR C CB  1 
ATOM   6426 O  OG1 . THR C 1 235 ? -72.217 9.819   46.026  1    98.51  ? 231 THR C OG1 1 
ATOM   6427 C  CG2 . THR C 1 235 ? -71.854 12.202  45.779  1    92.01  ? 231 THR C CG2 1 
ATOM   6428 N  N   . SER C 1 236 ? -69.229 8.273   46.385  1    91.28  ? 232 SER C N   1 
ATOM   6429 C  CA  . SER C 1 236 ? -68.922 6.976   47.029  1    97.17  ? 232 SER C CA  1 
ATOM   6430 C  C   . SER C 1 236 ? -67.406 6.804   47.087  1    93.86  ? 232 SER C C   1 
ATOM   6431 O  O   . SER C 1 236 ? -66.943 5.738   47.531  1    101.04 ? 232 SER C O   1 
ATOM   6432 C  CB  . SER C 1 236 ? -69.554 5.864   46.264  1    99.29  ? 232 SER C CB  1 
ATOM   6433 O  OG  . SER C 1 236 ? -68.874 5.664   45.033  1    108.79 ? 232 SER C OG  1 
ATOM   6434 N  N   . MET C 1 237 ? -66.672 7.825   46.663  1    91.85  ? 233 MET C N   1 
ATOM   6435 C  CA  . MET C 1 237 ? -65.199 7.676   46.593  1    95.23  ? 233 MET C CA  1 
ATOM   6436 C  C   . MET C 1 237 ? -64.598 7.744   48.005  1    95.68  ? 233 MET C C   1 
ATOM   6437 O  O   . MET C 1 237 ? -65.072 8.545   48.828  1    97.26  ? 233 MET C O   1 
ATOM   6438 C  CB  . MET C 1 237 ? -64.608 8.714   45.634  1    97.3   ? 233 MET C CB  1 
ATOM   6439 C  CG  . MET C 1 237 ? -64.543 8.2     44.22   1    99.69  ? 233 MET C CG  1 
ATOM   6440 S  SD  . MET C 1 237 ? -64.734 9.449   42.936  1    109.64 ? 233 MET C SD  1 
ATOM   6441 C  CE  . MET C 1 237 ? -65.405 8.386   41.652  1    100.09 ? 233 MET C CE  1 
ATOM   6442 N  N   . PRO C 1 238 ? -63.581 6.916   48.305  1    94.42  ? 234 PRO C N   1 
ATOM   6443 C  CA  . PRO C 1 238 ? -62.974 6.897   49.627  1    97.69  ? 234 PRO C CA  1 
ATOM   6444 C  C   . PRO C 1 238 ? -62.803 8.227   50.347  1    92.71  ? 234 PRO C C   1 
ATOM   6445 O  O   . PRO C 1 238 ? -63.277 8.358   51.487  1    90.67  ? 234 PRO C O   1 
ATOM   6446 C  CB  . PRO C 1 238 ? -61.615 6.306   49.231  1    101.37 ? 234 PRO C CB  1 
ATOM   6447 C  CG  . PRO C 1 238 ? -61.963 5.258   48.213  1    93.55  ? 234 PRO C CG  1 
ATOM   6448 C  CD  . PRO C 1 238 ? -62.996 5.97    47.37   1    93.05  ? 234 PRO C CD  1 
ATOM   6449 N  N   . ASP C 1 239 ? -62.123 9.183   49.718  1    88     ? 235 ASP C N   1 
ATOM   6450 C  CA  . ASP C 1 239 ? -61.817 10.471  50.395  1    92.99  ? 235 ASP C CA  1 
ATOM   6451 C  C   . ASP C 1 239 ? -62.87  11.529  50.05   1    100.9  ? 235 ASP C C   1 
ATOM   6452 O  O   . ASP C 1 239 ? -62.619 12.715  50.33   1    104.47 ? 235 ASP C O   1 
ATOM   6453 C  CB  . ASP C 1 239 ? -60.396 10.906  50.08   1    92.36  ? 235 ASP C CB  1 
ATOM   6454 C  CG  . ASP C 1 239 ? -59.305 10.027  50.668  1    91.66  ? 235 ASP C CG  1 
ATOM   6455 O  OD1 . ASP C 1 239 ? -59.413 9.686   51.861  1    94.18  ? 235 ASP C OD1 1 
ATOM   6456 O  OD2 . ASP C 1 239 ? -58.36  9.695   49.927  1    91.71  ? 235 ASP C OD2 1 
ATOM   6457 N  N   . TYR C 1 240 ? -63.995 11.129  49.456  1    96.96  ? 236 TYR C N   1 
ATOM   6458 C  CA  . TYR C 1 240 ? -65.074 12.076  49.209  1    90.39  ? 236 TYR C CA  1 
ATOM   6459 C  C   . TYR C 1 240 ? -65.674 12.503  50.554  1    93     ? 236 TYR C C   1 
ATOM   6460 O  O   . TYR C 1 240 ? -65.727 11.7    51.482  1    92.08  ? 236 TYR C O   1 
ATOM   6461 C  CB  . TYR C 1 240 ? -66.122 11.478  48.258  1    88.5   ? 236 TYR C CB  1 
ATOM   6462 C  CG  . TYR C 1 240 ? -67.289 12.427  48.016  1    90.92  ? 236 TYR C CG  1 
ATOM   6463 C  CD1 . TYR C 1 240 ? -67.248 13.365  46.991  1    87.02  ? 236 TYR C CD1 1 
ATOM   6464 C  CD2 . TYR C 1 240 ? -68.409 12.425  48.853  1    96.04  ? 236 TYR C CD2 1 
ATOM   6465 C  CE1 . TYR C 1 240 ? -68.304 14.237  46.781  1    88.83  ? 236 TYR C CE1 1 
ATOM   6466 C  CE2 . TYR C 1 240 ? -69.472 13.297  48.66   1    94.55  ? 236 TYR C CE2 1 
ATOM   6467 C  CZ  . TYR C 1 240 ? -69.414 14.209  47.62   1    93.99  ? 236 TYR C CZ  1 
ATOM   6468 O  OH  . TYR C 1 240 ? -70.468 15.075  47.472  1    95.8   ? 236 TYR C OH  1 
ATOM   6469 N  N   . LYS C 1 241 ? -66.134 13.761  50.651  1    91.93  ? 237 LYS C N   1 
ATOM   6470 C  CA  . LYS C 1 241 ? -66.728 14.304  51.868  1    91.01  ? 237 LYS C CA  1 
ATOM   6471 C  C   . LYS C 1 241 ? -68.048 15.014  51.551  1    88.73  ? 237 LYS C C   1 
ATOM   6472 O  O   . LYS C 1 241 ? -68.046 16.011  50.818  1    83.72  ? 237 LYS C O   1 
ATOM   6473 C  CB  . LYS C 1 241 ? -65.78  15.257  52.616  1    98.55  ? 237 LYS C CB  1 
ATOM   6474 C  CG  . LYS C 1 241 ? -64.527 14.613  53.227  1    104.44 ? 237 LYS C CG  1 
ATOM   6475 C  CD  . LYS C 1 241 ? -63.588 15.581  53.944  1    117.13 ? 237 LYS C CD  1 
ATOM   6476 C  CE  . LYS C 1 241 ? -62.378 14.913  54.555  1    127.79 ? 237 LYS C CE  1 
ATOM   6477 N  NZ  . LYS C 1 241 ? -61.463 15.85   55.225  1    114.49 ? 237 LYS C NZ  1 
ATOM   6478 N  N   . PRO C 1 242 ? -69.197 14.561  52.123  1    90.57  ? 238 PRO C N   1 
ATOM   6479 C  CA  . PRO C 1 242 ? -70.479 15.253  51.943  1    93.26  ? 238 PRO C CA  1 
ATOM   6480 C  C   . PRO C 1 242 ? -70.436 16.739  52.33   1    93.49  ? 238 PRO C C   1 
ATOM   6481 O  O   . PRO C 1 242 ? -71.177 17.55   51.775  1    90.47  ? 238 PRO C O   1 
ATOM   6482 C  CB  . PRO C 1 242 ? -71.53  14.452  52.773  1    88.84  ? 238 PRO C CB  1 
ATOM   6483 C  CG  . PRO C 1 242 ? -70.811 13.193  53.239  1    86.01  ? 238 PRO C CG  1 
ATOM   6484 C  CD  . PRO C 1 242 ? -69.319 13.4    53.022  1    86.64  ? 238 PRO C CD  1 
ATOM   6485 N  N   . SER C 1 243 ? -69.549 17.105  53.266  1    96.66  ? 239 SER C N   1 
ATOM   6486 C  CA  . SER C 1 243 ? -69.408 18.487  53.714  1    98.34  ? 239 SER C CA  1 
ATOM   6487 C  C   . SER C 1 243 ? -68.759 19.399  52.657  1    99.4   ? 239 SER C C   1 
ATOM   6488 O  O   . SER C 1 243 ? -68.846 20.617  52.768  1    106.97 ? 239 SER C O   1 
ATOM   6489 C  CB  . SER C 1 243 ? -68.692 18.555  55.033  1    93.8   ? 239 SER C CB  1 
ATOM   6490 O  OG  . SER C 1 243 ? -67.489 17.797  54.952  1    95.94  ? 239 SER C OG  1 
ATOM   6491 N  N   . PHE C 1 244 ? -68.125 18.854  51.614  1    90.36  ? 240 PHE C N   1 
ATOM   6492 C  CA  . PHE C 1 244 ? -67.549 19.717  50.586  1    92.36  ? 240 PHE C CA  1 
ATOM   6493 C  C   . PHE C 1 244 ? -68.519 20.852  50.227  1    95.29  ? 240 PHE C C   1 
ATOM   6494 O  O   . PHE C 1 244 ? -69.642 20.55   49.825  1    93.52  ? 240 PHE C O   1 
ATOM   6495 C  CB  . PHE C 1 244 ? -67.201 18.93   49.318  1    90.91  ? 240 PHE C CB  1 
ATOM   6496 C  CG  . PHE C 1 244 ? -66.027 17.973  49.454  1    96.93  ? 240 PHE C CG  1 
ATOM   6497 C  CD1 . PHE C 1 244 ? -65.013 18.2    50.384  1    101.23 ? 240 PHE C CD1 1 
ATOM   6498 C  CD2 . PHE C 1 244 ? -65.933 16.842  48.644  1    97.42  ? 240 PHE C CD2 1 
ATOM   6499 C  CE1 . PHE C 1 244 ? -63.932 17.327  50.488  1    110.81 ? 240 PHE C CE1 1 
ATOM   6500 C  CE2 . PHE C 1 244 ? -64.849 15.975  48.749  1    94.73  ? 240 PHE C CE2 1 
ATOM   6501 C  CZ  . PHE C 1 244 ? -63.847 16.217  49.666  1    99.94  ? 240 PHE C CZ  1 
ATOM   6502 N  N   . PRO C 1 245 ? -68.142 22.166  50.335  1    93.23  ? 241 PRO C N   1 
ATOM   6503 C  CA  . PRO C 1 245 ? -68.987 23.276  49.863  1    91.23  ? 241 PRO C CA  1 
ATOM   6504 C  C   . PRO C 1 245 ? -69.396 23.004  48.411  1    100.92 ? 241 PRO C C   1 
ATOM   6505 O  O   . PRO C 1 245 ? -68.678 22.304  47.688  1    99.29  ? 241 PRO C O   1 
ATOM   6506 C  CB  . PRO C 1 245 ? -68.107 24.535  49.957  1    77.73  ? 241 PRO C CB  1 
ATOM   6507 C  CG  . PRO C 1 245 ? -67.1   24.17   50.985  1    78.74  ? 241 PRO C CG  1 
ATOM   6508 C  CD  . PRO C 1 245 ? -66.85  22.668  50.822  1    82.02  ? 241 PRO C CD  1 
ATOM   6509 N  N   . LYS C 1 246 ? -70.558 23.536  48.002  1    110.05 ? 242 LYS C N   1 
ATOM   6510 C  CA  . LYS C 1 246 ? -71.076 23.343  46.649  1    107.11 ? 242 LYS C CA  1 
ATOM   6511 C  C   . LYS C 1 246 ? -70.886 24.624  45.825  1    98.77  ? 242 LYS C C   1 
ATOM   6512 O  O   . LYS C 1 246 ? -71.773 25.476  45.821  1    91.48  ? 242 LYS C O   1 
ATOM   6513 C  CB  . LYS C 1 246 ? -72.54  22.858  46.683  1    112.76 ? 242 LYS C CB  1 
ATOM   6514 C  CG  . LYS C 1 246 ? -72.813 21.512  47.382  1    113.37 ? 242 LYS C CG  1 
ATOM   6515 C  CD  . LYS C 1 246 ? -72.156 20.296  46.709  1    129.25 ? 242 LYS C CD  1 
ATOM   6516 C  CE  . LYS C 1 246 ? -72.424 18.925  47.284  1    126.36 ? 242 LYS C CE  1 
ATOM   6517 N  NZ  . LYS C 1 246 ? -71.732 17.837  46.583  1    125.26 ? 242 LYS C NZ  1 
ATOM   6518 N  N   . TRP C 1 247 ? -69.746 24.739  45.113  1    97.72  ? 243 TRP C N   1 
ATOM   6519 C  CA  . TRP C 1 247 ? -69.429 25.9    44.282  1    91.65  ? 243 TRP C CA  1 
ATOM   6520 C  C   . TRP C 1 247 ? -70.078 25.756  42.908  1    91.3   ? 243 TRP C C   1 
ATOM   6521 O  O   . TRP C 1 247 ? -70.484 24.666  42.528  1    91.61  ? 243 TRP C O   1 
ATOM   6522 C  CB  . TRP C 1 247 ? -67.912 26.142  44.155  1    81.38  ? 243 TRP C CB  1 
ATOM   6523 C  CG  . TRP C 1 247 ? -67.218 26.593  45.42   1    78.22  ? 243 TRP C CG  1 
ATOM   6524 C  CD1 . TRP C 1 247 ? -67.17  27.851  45.953  1    70.49  ? 243 TRP C CD1 1 
ATOM   6525 C  CD2 . TRP C 1 247 ? -66.441 25.746  46.308  1    75.5   ? 243 TRP C CD2 1 
ATOM   6526 N  NE1 . TRP C 1 247 ? -66.432 27.842  47.107  1    70.62  ? 243 TRP C NE1 1 
ATOM   6527 C  CE2 . TRP C 1 247 ? -65.972 26.57   47.357  1    74.85  ? 243 TRP C CE2 1 
ATOM   6528 C  CE3 . TRP C 1 247 ? -66.098 24.386  46.316  1    70.67  ? 243 TRP C CE3 1 
ATOM   6529 C  CZ2 . TRP C 1 247 ? -65.189 26.062  48.405  1    74.69  ? 243 TRP C CZ2 1 
ATOM   6530 C  CZ3 . TRP C 1 247 ? -65.327 23.899  47.352  1    73.1   ? 243 TRP C CZ3 1 
ATOM   6531 C  CH2 . TRP C 1 247 ? -64.865 24.721  48.389  1    72.43  ? 243 TRP C CH2 1 
ATOM   6532 N  N   . ALA C 1 248 ? -70.085 26.853  42.155  1    94.9   ? 244 ALA C N   1 
ATOM   6533 C  CA  . ALA C 1 248 ? -70.642 26.833  40.786  1    96.39  ? 244 ALA C CA  1 
ATOM   6534 C  C   . ALA C 1 248 ? -69.494 26.948  39.787  1    98.67  ? 244 ALA C C   1 
ATOM   6535 O  O   . ALA C 1 248 ? -68.506 27.645  40.084  1    92.69  ? 244 ALA C O   1 
ATOM   6536 C  CB  . ALA C 1 248 ? -71.617 27.965  40.623  1    88.39  ? 244 ALA C CB  1 
ATOM   6537 N  N   . ARG C 1 249 ? -69.625 26.29   38.637  1    101.14 ? 245 ARG C N   1 
ATOM   6538 C  CA  . ARG C 1 249 ? -68.533 26.291  37.638  1    99.34  ? 245 ARG C CA  1 
ATOM   6539 C  C   . ARG C 1 249 ? -68.325 27.714  37.128  1    105.97 ? 245 ARG C C   1 
ATOM   6540 O  O   . ARG C 1 249 ? -69.329 28.395  36.848  1    109.06 ? 245 ARG C O   1 
ATOM   6541 C  CB  . ARG C 1 249 ? -68.861 25.374  36.458  1    93.27  ? 245 ARG C CB  1 
ATOM   6542 C  CG  . ARG C 1 249 ? -67.778 25.297  35.392  1    93.8   ? 245 ARG C CG  1 
ATOM   6543 C  CD  . ARG C 1 249 ? -68.156 24.314  34.304  1    92.98  ? 245 ARG C CD  1 
ATOM   6544 N  NE  . ARG C 1 249 ? -67.12  24.2    33.273  1    93.51  ? 245 ARG C NE  1 
ATOM   6545 C  CZ  . ARG C 1 249 ? -67.126 23.275  32.327  1    84.79  ? 245 ARG C CZ  1 
ATOM   6546 N  NH1 . ARG C 1 249 ? -66.044 23.061  31.605  1    78.28  ? 245 ARG C NH1 1 
ATOM   6547 N  NH2 . ARG C 1 249 ? -68.219 22.571  32.102  1    78.97  ? 245 ARG C NH2 1 
ATOM   6548 N  N   . GLN C 1 250 ? -67.07  28.139  37.023  1    107.98 ? 246 GLN C N   1 
ATOM   6549 C  CA  . GLN C 1 250 ? -66.782 29.469  36.443  1    109.47 ? 246 GLN C CA  1 
ATOM   6550 C  C   . GLN C 1 250 ? -66.755 29.32   34.921  1    102.43 ? 246 GLN C C   1 
ATOM   6551 O  O   . GLN C 1 250 ? -66.447 28.218  34.437  1    96.22  ? 246 GLN C O   1 
ATOM   6552 C  CB  . GLN C 1 250 ? -65.45  29.983  36.981  1    106.26 ? 246 GLN C CB  1 
ATOM   6553 C  CG  . GLN C 1 250 ? -65.228 29.665  38.454  1    105.04 ? 246 GLN C CG  1 
ATOM   6554 C  CD  . GLN C 1 250 ? -64.051 30.406  39.043  1    103.17 ? 246 GLN C CD  1 
ATOM   6555 O  OE1 . GLN C 1 250 ? -63.488 31.313  38.422  1    104.09 ? 246 GLN C OE1 1 
ATOM   6556 N  NE2 . GLN C 1 250 ? -63.669 30.025  40.252  1    106.23 ? 246 GLN C NE2 1 
ATOM   6557 N  N   . ASP C 1 251 ? -67.071 30.393  34.201  1    100.3  ? 247 ASP C N   1 
ATOM   6558 C  CA  . ASP C 1 251 ? -66.995 30.349  32.72   1    95.71  ? 247 ASP C CA  1 
ATOM   6559 C  C   . ASP C 1 251 ? -65.529 30.224  32.323  1    90.03  ? 247 ASP C C   1 
ATOM   6560 O  O   . ASP C 1 251 ? -64.723 31.033  32.781  1    83.44  ? 247 ASP C O   1 
ATOM   6561 C  CB  . ASP C 1 251 ? -67.679 31.545  32.082  1    100.91 ? 247 ASP C CB  1 
ATOM   6562 C  CG  . ASP C 1 251 ? -69.184 31.607  32.282  1    108.96 ? 247 ASP C CG  1 
ATOM   6563 O  OD1 . ASP C 1 251 ? -69.805 30.529  32.365  1    121.29 ? 247 ASP C OD1 1 
ATOM   6564 O  OD2 . ASP C 1 251 ? -69.719 32.732  32.355  1    104.09 ? 247 ASP C OD2 1 
ATOM   6565 N  N   . PHE C 1 252 ? -65.203 29.198  31.55   1    93.05  ? 248 PHE C N   1 
ATOM   6566 C  CA  . PHE C 1 252 ? -63.841 29.034  31.058  1    93.88  ? 248 PHE C CA  1 
ATOM   6567 C  C   . PHE C 1 252 ? -63.362 30.328  30.405  1    98.64  ? 248 PHE C C   1 
ATOM   6568 O  O   . PHE C 1 252 ? -62.164 30.582  30.319  1    93.79  ? 248 PHE C O   1 
ATOM   6569 C  CB  . PHE C 1 252 ? -63.774 27.847  30.097  1    93.76  ? 248 PHE C CB  1 
ATOM   6570 C  CG  . PHE C 1 252 ? -63.529 26.522  30.803  1    98.94  ? 248 PHE C CG  1 
ATOM   6571 C  CD1 . PHE C 1 252 ? -64.199 26.208  31.982  1    100.9  ? 248 PHE C CD1 1 
ATOM   6572 C  CD2 . PHE C 1 252 ? -62.608 25.611  30.286  1    92.13  ? 248 PHE C CD2 1 
ATOM   6573 C  CE1 . PHE C 1 252 ? -63.94  25.012  32.624  1    106.12 ? 248 PHE C CE1 1 
ATOM   6574 C  CE2 . PHE C 1 252 ? -62.361 24.41   30.922  1    92.25  ? 248 PHE C CE2 1 
ATOM   6575 C  CZ  . PHE C 1 252 ? -63.025 24.118  32.091  1    99.76  ? 248 PHE C CZ  1 
ATOM   6576 N  N   . SER C 1 253 ? -64.329 31.146  29.968  1    105.23 ? 249 SER C N   1 
ATOM   6577 C  CA  . SER C 1 253 ? -64.096 32.482  29.448  1    103.52 ? 249 SER C CA  1 
ATOM   6578 C  C   . SER C 1 253 ? -63.465 33.382  30.523  1    107.95 ? 249 SER C C   1 
ATOM   6579 O  O   . SER C 1 253 ? -62.794 34.364  30.21   1    108.31 ? 249 SER C O   1 
ATOM   6580 C  CB  . SER C 1 253 ? -65.376 33.034  28.882  1    99.23  ? 249 SER C CB  1 
ATOM   6581 O  OG  . SER C 1 253 ? -66.345 33.185  29.91   1    110.42 ? 249 SER C OG  1 
ATOM   6582 N  N   . LYS C 1 254 ? -63.673 33.029  31.793  1    102.08 ? 250 LYS C N   1 
ATOM   6583 C  CA  . LYS C 1 254 ? -63.077 33.752  32.906  1    97.74  ? 250 LYS C CA  1 
ATOM   6584 C  C   . LYS C 1 254 ? -61.786 33.051  33.314  1    89.89  ? 250 LYS C C   1 
ATOM   6585 O  O   . LYS C 1 254 ? -60.816 33.722  33.661  1    82.99  ? 250 LYS C O   1 
ATOM   6586 C  CB  . LYS C 1 254 ? -64.038 33.843  34.097  1    101.21 ? 250 LYS C CB  1 
ATOM   6587 C  CG  . LYS C 1 254 ? -65.489 34.073  33.677  1    116.63 ? 250 LYS C CG  1 
ATOM   6588 C  CD  . LYS C 1 254 ? -66.487 34.516  34.751  1    116.33 ? 250 LYS C CD  1 
ATOM   6589 C  CE  . LYS C 1 254 ? -67.321 33.386  35.326  1    110.52 ? 250 LYS C CE  1 
ATOM   6590 N  NZ  . LYS C 1 254 ? -68.433 33.901  36.134  1    99.91  ? 250 LYS C NZ  1 
ATOM   6591 N  N   . VAL C 1 255 ? -61.805 31.709  33.252  1    86.94  ? 251 VAL C N   1 
ATOM   6592 C  CA  . VAL C 1 255 ? -60.694 30.871  33.681  1    83.95  ? 251 VAL C CA  1 
ATOM   6593 C  C   . VAL C 1 255 ? -59.513 31.081  32.736  1    80.6   ? 251 VAL C C   1 
ATOM   6594 O  O   . VAL C 1 255 ? -58.406 31.343  33.179  1    77.02  ? 251 VAL C O   1 
ATOM   6595 C  CB  . VAL C 1 255 ? -61.099 29.387  33.744  1    87.09  ? 251 VAL C CB  1 
ATOM   6596 C  CG1 . VAL C 1 255 ? -59.973 28.505  34.276  1    82.7   ? 251 VAL C CG1 1 
ATOM   6597 C  CG2 . VAL C 1 255 ? -62.379 29.198  34.552  1    85.75  ? 251 VAL C CG2 1 
ATOM   6598 N  N   . VAL C 1 256 ? -59.771 30.982  31.432  1    79.69  ? 252 VAL C N   1 
ATOM   6599 C  CA  . VAL C 1 256 ? -58.767 31.175  30.402  1    79     ? 252 VAL C CA  1 
ATOM   6600 C  C   . VAL C 1 256 ? -59.278 32.259  29.445  1    85.43  ? 252 VAL C C   1 
ATOM   6601 O  O   . VAL C 1 256 ? -59.666 31.995  28.298  1    82.78  ? 252 VAL C O   1 
ATOM   6602 C  CB  . VAL C 1 256 ? -58.42  29.854  29.68   1    73.14  ? 252 VAL C CB  1 
ATOM   6603 C  CG1 . VAL C 1 256 ? -57.779 28.822  30.605  1    64.65  ? 252 VAL C CG1 1 
ATOM   6604 C  CG2 . VAL C 1 256 ? -59.632 29.279  28.955  1    71.65  ? 252 VAL C CG2 1 
ATOM   6605 N  N   . PRO C 1 257 ? -59.297 33.538  29.89   1    92.91  ? 253 PRO C N   1 
ATOM   6606 C  CA  . PRO C 1 257 ? -59.806 34.629  29.052  1    89.17  ? 253 PRO C CA  1 
ATOM   6607 C  C   . PRO C 1 257 ? -59.304 34.619  27.606  1    92.22  ? 253 PRO C C   1 
ATOM   6608 O  O   . PRO C 1 257 ? -60.111 34.766  26.694  1    96.15  ? 253 PRO C O   1 
ATOM   6609 C  CB  . PRO C 1 257 ? -59.372 35.893  29.803  1    85.69  ? 253 PRO C CB  1 
ATOM   6610 C  CG  . PRO C 1 257 ? -59.319 35.449  31.247  1    89.45  ? 253 PRO C CG  1 
ATOM   6611 C  CD  . PRO C 1 257 ? -58.814 34.007  31.203  1    91.18  ? 253 PRO C CD  1 
ATOM   6612 N  N   . PRO C 1 258 ? -57.986 34.433  27.326  1    93     ? 254 PRO C N   1 
ATOM   6613 C  CA  . PRO C 1 258 ? -57.473 34.541  25.957  1    83.96  ? 254 PRO C CA  1 
ATOM   6614 C  C   . PRO C 1 258 ? -57.941 33.444  25.011  1    78.94  ? 254 PRO C C   1 
ATOM   6615 O  O   . PRO C 1 258 ? -57.844 33.602  23.797  1    77.01  ? 254 PRO C O   1 
ATOM   6616 C  CB  . PRO C 1 258 ? -55.935 34.514  26.105  1    82.16  ? 254 PRO C CB  1 
ATOM   6617 C  CG  . PRO C 1 258 ? -55.685 34.66   27.59   1    85.11  ? 254 PRO C CG  1 
ATOM   6618 C  CD  . PRO C 1 258 ? -56.915 34.122  28.292  1    87.98  ? 254 PRO C CD  1 
ATOM   6619 N  N   . LEU C 1 259 ? -58.414 32.327  25.575  1    77.08  ? 255 LEU C N   1 
ATOM   6620 C  CA  . LEU C 1 259 ? -58.697 31.139  24.781  1    76.94  ? 255 LEU C CA  1 
ATOM   6621 C  C   . LEU C 1 259 ? -59.961 31.354  23.952  1    82.09  ? 255 LEU C C   1 
ATOM   6622 O  O   . LEU C 1 259 ? -60.854 32.07   24.398  1    93.03  ? 255 LEU C O   1 
ATOM   6623 C  CB  . LEU C 1 259 ? -58.82  29.94   25.72   1    71.14  ? 255 LEU C CB  1 
ATOM   6624 C  CG  . LEU C 1 259 ? -58.449 28.592  25.107  1    66.41  ? 255 LEU C CG  1 
ATOM   6625 C  CD1 . LEU C 1 259 ? -57.246 28.738  24.189  1    65.57  ? 255 LEU C CD1 1 
ATOM   6626 C  CD2 . LEU C 1 259 ? -58.158 27.572  26.192  1    64.88  ? 255 LEU C CD2 1 
ATOM   6627 N  N   . ASP C 1 260 ? -60.022 30.743  22.761  1    80.92  ? 256 ASP C N   1 
ATOM   6628 C  CA  . ASP C 1 260 ? -61.188 30.825  21.883  1    85.48  ? 256 ASP C CA  1 
ATOM   6629 C  C   . ASP C 1 260 ? -62.234 29.794  22.335  1    87.45  ? 256 ASP C C   1 
ATOM   6630 O  O   . ASP C 1 260 ? -62.074 29.131  23.37   1    92.61  ? 256 ASP C O   1 
ATOM   6631 C  CB  . ASP C 1 260 ? -60.777 30.613  20.432  1    88.13  ? 256 ASP C CB  1 
ATOM   6632 C  CG  . ASP C 1 260 ? -59.897 29.379  20.229  1    94.76  ? 256 ASP C CG  1 
ATOM   6633 O  OD1 . ASP C 1 260 ? -58.678 29.482  20.502  1    88.46  ? 256 ASP C OD1 1 
ATOM   6634 O  OD2 . ASP C 1 260 ? -60.439 28.295  19.897  1    96.44  ? 256 ASP C OD2 1 
ATOM   6635 N  N   . GLU C 1 261 ? -63.298 29.636  21.539  1    81.69  ? 257 GLU C N   1 
ATOM   6636 C  CA  . GLU C 1 261 ? -64.354 28.678  21.848  1    85.23  ? 257 GLU C CA  1 
ATOM   6637 C  C   . GLU C 1 261 ? -63.904 27.22   21.66   1    81.88  ? 257 GLU C C   1 
ATOM   6638 O  O   . GLU C 1 261 ? -64.247 26.349  22.459  1    80.73  ? 257 GLU C O   1 
ATOM   6639 C  CB  . GLU C 1 261 ? -65.545 29.073  20.977  1    89.4   ? 257 GLU C CB  1 
ATOM   6640 C  CG  . GLU C 1 261 ? -66.636 28.012  20.918  1    97.13  ? 257 GLU C CG  1 
ATOM   6641 C  CD  . GLU C 1 261 ? -67.47  28.209  19.663  1    108.81 ? 257 GLU C CD  1 
ATOM   6642 O  OE1 . GLU C 1 261 ? -68.204 27.257  19.308  1    114.95 ? 257 GLU C OE1 1 
ATOM   6643 O  OE2 . GLU C 1 261 ? -67.37  29.298  19.036  1    108.11 ? 257 GLU C OE2 1 
ATOM   6644 N  N   . ASP C 1 262 ? -63.162 26.959  20.575  1    80.7   ? 258 ASP C N   1 
ATOM   6645 C  CA  . ASP C 1 262 ? -62.572 25.657  20.289  1    76.51  ? 258 ASP C CA  1 
ATOM   6646 C  C   . ASP C 1 262 ? -61.621 25.233  21.415  1    75.26  ? 258 ASP C C   1 
ATOM   6647 O  O   . ASP C 1 262 ? -61.683 24.107  21.914  1    76.85  ? 258 ASP C O   1 
ATOM   6648 C  CB  . ASP C 1 262 ? -61.864 25.655  18.942  1    74.4   ? 258 ASP C CB  1 
ATOM   6649 C  CG  . ASP C 1 262 ? -62.772 25.481  17.732  1    79.83  ? 258 ASP C CG  1 
ATOM   6650 O  OD1 . ASP C 1 262 ? -63.899 24.99   17.902  1    80.12  ? 258 ASP C OD1 1 
ATOM   6651 O  OD2 . ASP C 1 262 ? -62.352 25.861  16.631  1    80.51  ? 258 ASP C OD2 1 
ATOM   6652 N  N   . GLY C 1 263 ? -60.74  26.154  21.819  1    68.51  ? 259 GLY C N   1 
ATOM   6653 C  CA  . GLY C 1 263 ? -59.777 25.857  22.858  1    61.77  ? 259 GLY C CA  1 
ATOM   6654 C  C   . GLY C 1 263 ? -60.481 25.555  24.176  1    65.04  ? 259 GLY C C   1 
ATOM   6655 O  O   . GLY C 1 263 ? -60.124 24.61   24.876  1    70.09  ? 259 GLY C O   1 
ATOM   6656 N  N   . ARG C 1 264 ? -61.498 26.353  24.503  1    68.36  ? 260 ARG C N   1 
ATOM   6657 C  CA  . ARG C 1 264 ? -62.218 26.166  25.752  1    70.47  ? 260 ARG C CA  1 
ATOM   6658 C  C   . ARG C 1 264 ? -62.948 24.821  25.729  1    68.14  ? 260 ARG C C   1 
ATOM   6659 O  O   . ARG C 1 264 ? -63.048 24.126  26.743  1    67.7   ? 260 ARG C O   1 
ATOM   6660 C  CB  . ARG C 1 264 ? -63.134 27.373  25.997  1    74.6   ? 260 ARG C CB  1 
ATOM   6661 C  CG  . ARG C 1 264 ? -62.358 28.622  26.404  1    86.49  ? 260 ARG C CG  1 
ATOM   6662 C  CD  . ARG C 1 264 ? -63.267 29.717  26.973  1    97.93  ? 260 ARG C CD  1 
ATOM   6663 N  NE  . ARG C 1 264 ? -64.391 30.042  26.078  1    108.44 ? 260 ARG C NE  1 
ATOM   6664 C  CZ  . ARG C 1 264 ? -64.345 30.868  25.036  1    108.58 ? 260 ARG C CZ  1 
ATOM   6665 N  NH1 . ARG C 1 264 ? -63.302 31.669  24.877  1    117.29 ? 260 ARG C NH1 1 
ATOM   6666 N  NH2 . ARG C 1 264 ? -65.356 30.923  24.185  1    93.28  ? 260 ARG C NH2 1 
ATOM   6667 N  N   . SER C 1 265 ? -63.456 24.458  24.552  1    65.1   ? 261 SER C N   1 
ATOM   6668 C  CA  . SER C 1 265 ? -64.12  23.183  24.383  1    63.22  ? 261 SER C CA  1 
ATOM   6669 C  C   . SER C 1 265 ? -63.151 22.05   24.715  1    61.65  ? 261 SER C C   1 
ATOM   6670 O  O   . SER C 1 265 ? -63.44  21.189  25.545  1    63.12  ? 261 SER C O   1 
ATOM   6671 C  CB  . SER C 1 265 ? -64.635 23.061  22.988  1    66.22  ? 261 SER C CB  1 
ATOM   6672 O  OG  . SER C 1 265 ? -65.316 21.83   22.825  1    68.89  ? 261 SER C OG  1 
ATOM   6673 N  N   . LEU C 1 266 ? -61.985 22.075  24.07   1    57.92  ? 262 LEU C N   1 
ATOM   6674 C  CA  . LEU C 1 266 ? -60.96  21.075  24.322  1    61.81  ? 262 LEU C CA  1 
ATOM   6675 C  C   . LEU C 1 266 ? -60.535 21.077  25.805  1    60.96  ? 262 LEU C C   1 
ATOM   6676 O  O   . LEU C 1 266 ? -60.464 20.025  26.461  1    58.9   ? 262 LEU C O   1 
ATOM   6677 C  CB  . LEU C 1 266 ? -59.791 21.327  23.365  1    58.83  ? 262 LEU C CB  1 
ATOM   6678 C  CG  . LEU C 1 266 ? -58.561 20.42   23.547  1    55.32  ? 262 LEU C CG  1 
ATOM   6679 C  CD1 . LEU C 1 266 ? -58.943 18.958  23.435  1    51     ? 262 LEU C CD1 1 
ATOM   6680 C  CD2 . LEU C 1 266 ? -57.464 20.786  22.542  1    50.73  ? 262 LEU C CD2 1 
ATOM   6681 N  N   . LEU C 1 267 ? -60.262 22.271  26.342  1    57.89  ? 263 LEU C N   1 
ATOM   6682 C  CA  . LEU C 1 267 ? -59.812 22.412  27.716  1    55.19  ? 263 LEU C CA  1 
ATOM   6683 C  C   . LEU C 1 267 ? -60.806 21.743  28.67   1    58.61  ? 263 LEU C C   1 
ATOM   6684 O  O   . LEU C 1 267 ? -60.401 21.008  29.558  1    60.18  ? 263 LEU C O   1 
ATOM   6685 C  CB  . LEU C 1 267 ? -59.59  23.885  28.06   1    52.83  ? 263 LEU C CB  1 
ATOM   6686 C  CG  . LEU C 1 267 ? -59.104 24.16   29.49   1    50.65  ? 263 LEU C CG  1 
ATOM   6687 C  CD1 . LEU C 1 267 ? -57.91  23.259  29.838  1    52.64  ? 263 LEU C CD1 1 
ATOM   6688 C  CD2 . LEU C 1 267 ? -58.722 25.621  29.683  1    47.67  ? 263 LEU C CD2 1 
ATOM   6689 N  N   . SER C 1 268 ? -62.113 21.968  28.479  1    59.84  ? 264 SER C N   1 
ATOM   6690 C  CA  . SER C 1 268 ? -63.101 21.41   29.389  1    62.1   ? 264 SER C CA  1 
ATOM   6691 C  C   . SER C 1 268 ? -63.177 19.884  29.264  1    64.88  ? 264 SER C C   1 
ATOM   6692 O  O   . SER C 1 268 ? -63.374 19.191  30.264  1    65.05  ? 264 SER C O   1 
ATOM   6693 C  CB  . SER C 1 268 ? -64.435 22.053  29.197  1    61.39  ? 264 SER C CB  1 
ATOM   6694 O  OG  . SER C 1 268 ? -64.775 21.984  27.827  1    77.68  ? 264 SER C OG  1 
ATOM   6695 N  N   . GLN C 1 269 ? -63.024 19.359  28.032  1    61.21  ? 265 GLN C N   1 
ATOM   6696 C  CA  . GLN C 1 269 ? -63.057 17.924  27.795  1    57.7   ? 265 GLN C CA  1 
ATOM   6697 C  C   . GLN C 1 269 ? -61.849 17.235  28.422  1    57.44  ? 265 GLN C C   1 
ATOM   6698 O  O   . GLN C 1 269 ? -61.925 16.068  28.835  1    56.67  ? 265 GLN C O   1 
ATOM   6699 C  CB  . GLN C 1 269 ? -63.121 17.648  26.296  1    59.23  ? 265 GLN C CB  1 
ATOM   6700 C  CG  . GLN C 1 269 ? -64.496 17.912  25.697  1    60.28  ? 265 GLN C CG  1 
ATOM   6701 C  CD  . GLN C 1 269 ? -64.522 17.739  24.194  1    62.8   ? 265 GLN C CD  1 
ATOM   6702 O  OE1 . GLN C 1 269 ? -64.609 18.709  23.438  1    67.56  ? 265 GLN C OE1 1 
ATOM   6703 N  NE2 . GLN C 1 269 ? -64.428 16.504  23.732  1    61.45  ? 265 GLN C NE2 1 
ATOM   6704 N  N   . MET C 1 270 ? -60.72  17.962  28.463  1    54.5   ? 266 MET C N   1 
ATOM   6705 C  CA  . MET C 1 270 ? -59.525 17.449  29.113  1    52.84  ? 266 MET C CA  1 
ATOM   6706 C  C   . MET C 1 270 ? -59.684 17.44   30.632  1    55     ? 266 MET C C   1 
ATOM   6707 O  O   . MET C 1 270 ? -59.071 16.612  31.307  1    54.79  ? 266 MET C O   1 
ATOM   6708 C  CB  . MET C 1 270 ? -58.294 18.255  28.702  1    48.51  ? 266 MET C CB  1 
ATOM   6709 C  CG  . MET C 1 270 ? -57.911 17.971  27.275  1    49.35  ? 266 MET C CG  1 
ATOM   6710 S  SD  . MET C 1 270 ? -56.53  18.95   26.676  1    55.7   ? 266 MET C SD  1 
ATOM   6711 C  CE  . MET C 1 270 ? -55.106 18.067  27.347  1    48.51  ? 266 MET C CE  1 
ATOM   6712 N  N   . LEU C 1 271 ? -60.497 18.373  31.158  1    55.58  ? 267 LEU C N   1 
ATOM   6713 C  CA  . LEU C 1 271 ? -60.62  18.578  32.593  1    58.84  ? 267 LEU C CA  1 
ATOM   6714 C  C   . LEU C 1 271 ? -61.963 18.06   33.106  1    61.54  ? 267 LEU C C   1 
ATOM   6715 O  O   . LEU C 1 271 ? -62.458 18.498  34.139  1    63.34  ? 267 LEU C O   1 
ATOM   6716 C  CB  . LEU C 1 271 ? -60.404 20.052  32.935  1    57.27  ? 267 LEU C CB  1 
ATOM   6717 C  CG  . LEU C 1 271 ? -58.994 20.604  32.698  1    55.9   ? 267 LEU C CG  1 
ATOM   6718 C  CD1 . LEU C 1 271 ? -58.957 22.062  33.121  1    59.93  ? 267 LEU C CD1 1 
ATOM   6719 C  CD2 . LEU C 1 271 ? -57.889 19.795  33.398  1    53.31  ? 267 LEU C CD2 1 
ATOM   6720 N  N   . HIS C 1 272 ? -62.53  17.087  32.398  1    65.85  ? 268 HIS C N   1 
ATOM   6721 C  CA  . HIS C 1 272 ? -63.767 16.466  32.84   1    65.74  ? 268 HIS C CA  1 
ATOM   6722 C  C   . HIS C 1 272 ? -63.527 15.731  34.162  1    64.15  ? 268 HIS C C   1 
ATOM   6723 O  O   . HIS C 1 272 ? -62.514 15.05   34.352  1    56.65  ? 268 HIS C O   1 
ATOM   6724 C  CB  . HIS C 1 272 ? -64.296 15.538  31.744  1    72.74  ? 268 HIS C CB  1 
ATOM   6725 C  CG  . HIS C 1 272 ? -65.764 15.286  31.831  1    82.54  ? 268 HIS C CG  1 
ATOM   6726 N  ND1 . HIS C 1 272 ? -66.331 14.669  32.932  1    84.64  ? 268 HIS C ND1 1 
ATOM   6727 C  CD2 . HIS C 1 272 ? -66.776 15.613  30.998  1    76.88  ? 268 HIS C CD2 1 
ATOM   6728 C  CE1 . HIS C 1 272 ? -67.641 14.607  32.763  1    84.15  ? 268 HIS C CE1 1 
ATOM   6729 N  NE2 . HIS C 1 272 ? -67.932 15.173  31.597  1    86.52  ? 268 HIS C NE2 1 
ATOM   6730 N  N   . TYR C 1 273 ? -64.479 15.889  35.083  1    64.28  ? 269 TYR C N   1 
ATOM   6731 C  CA  . TYR C 1 273 ? -64.396 15.233  36.374  1    64.39  ? 269 TYR C CA  1 
ATOM   6732 C  C   . TYR C 1 273 ? -64.326 13.716  36.202  1    63.67  ? 269 TYR C C   1 
ATOM   6733 O  O   . TYR C 1 273 ? -63.412 13.077  36.709  1    60.74  ? 269 TYR C O   1 
ATOM   6734 C  CB  . TYR C 1 273 ? -65.591 15.668  37.22   1    68.04  ? 269 TYR C CB  1 
ATOM   6735 C  CG  . TYR C 1 273 ? -65.29  16.889  38.073  1    72.21  ? 269 TYR C CG  1 
ATOM   6736 C  CD1 . TYR C 1 273 ? -64.39  16.821  39.133  1    68.26  ? 269 TYR C CD1 1 
ATOM   6737 C  CD2 . TYR C 1 273 ? -65.926 18.101  37.833  1    74.43  ? 269 TYR C CD2 1 
ATOM   6738 C  CE1 . TYR C 1 273 ? -64.131 17.929  39.925  1    71.18  ? 269 TYR C CE1 1 
ATOM   6739 C  CE2 . TYR C 1 273 ? -65.658 19.216  38.617  1    75.48  ? 269 TYR C CE2 1 
ATOM   6740 C  CZ  . TYR C 1 273 ? -64.762 19.141  39.67   1    73.3   ? 269 TYR C CZ  1 
ATOM   6741 O  OH  . TYR C 1 273 ? -64.518 20.253  40.451  1    74.46  ? 269 TYR C OH  1 
ATOM   6742 N  N   . ASP C 1 274 ? -65.284 13.152  35.461  1    62.11  ? 270 ASP C N   1 
ATOM   6743 C  CA  . ASP C 1 274 ? -65.408 11.713  35.287  1    63.33  ? 270 ASP C CA  1 
ATOM   6744 C  C   . ASP C 1 274 ? -64.256 11.197  34.419  1    64.07  ? 270 ASP C C   1 
ATOM   6745 O  O   . ASP C 1 274 ? -64.138 11.563  33.248  1    63.31  ? 270 ASP C O   1 
ATOM   6746 C  CB  . ASP C 1 274 ? -66.772 11.364  34.695  1    64.53  ? 270 ASP C CB  1 
ATOM   6747 C  CG  . ASP C 1 274 ? -67.139 9.886   34.603  1    63.24  ? 270 ASP C CG  1 
ATOM   6748 O  OD1 . ASP C 1 274 ? -66.224 9.026   34.611  1    59.3   ? 270 ASP C OD1 1 
ATOM   6749 O  OD2 . ASP C 1 274 ? -68.362 9.609   34.54   1    67.26  ? 270 ASP C OD2 1 
ATOM   6750 N  N   . PRO C 1 275 ? -63.375 10.315  34.953  1    64.4   ? 271 PRO C N   1 
ATOM   6751 C  CA  . PRO C 1 275 ? -62.33  9.69    34.143  1    60.06  ? 271 PRO C CA  1 
ATOM   6752 C  C   . PRO C 1 275 ? -62.857 9.073   32.848  1    63.07  ? 271 PRO C C   1 
ATOM   6753 O  O   . PRO C 1 275 ? -62.185 9.109   31.815  1    63.74  ? 271 PRO C O   1 
ATOM   6754 C  CB  . PRO C 1 275 ? -61.786 8.619   35.094  1    59.17  ? 271 PRO C CB  1 
ATOM   6755 C  CG  . PRO C 1 275 ? -62.007 9.179   36.454  1    60.32  ? 271 PRO C CG  1 
ATOM   6756 C  CD  . PRO C 1 275 ? -63.33  9.9     36.364  1    65.17  ? 271 PRO C CD  1 
ATOM   6757 N  N   . ASN C 1 276 ? -64.072 8.512   32.913  1    62.47  ? 272 ASN C N   1 
ATOM   6758 C  CA  . ASN C 1 276 ? -64.625 7.78    31.788  1    62.16  ? 272 ASN C CA  1 
ATOM   6759 C  C   . ASN C 1 276 ? -65.018 8.729   30.662  1    59.93  ? 272 ASN C C   1 
ATOM   6760 O  O   . ASN C 1 276 ? -64.986 8.328   29.505  1    57.32  ? 272 ASN C O   1 
ATOM   6761 C  CB  . ASN C 1 276 ? -65.781 6.874   32.202  1    71.2   ? 272 ASN C CB  1 
ATOM   6762 C  CG  . ASN C 1 276 ? -65.361 5.807   33.192  1    73.08  ? 272 ASN C CG  1 
ATOM   6763 O  OD1 . ASN C 1 276 ? -64.368 5.096   32.979  1    69.85  ? 272 ASN C OD1 1 
ATOM   6764 N  ND2 . ASN C 1 276 ? -66.102 5.686   34.282  1    75.22  ? 272 ASN C ND2 1 
ATOM   6765 N  N   . LYS C 1 277 ? -65.382 9.97    31.001  1    61.93  ? 273 LYS C N   1 
ATOM   6766 C  CA  . LYS C 1 277 ? -65.864 10.925  30.013  1    62.93  ? 273 LYS C CA  1 
ATOM   6767 C  C   . LYS C 1 277 ? -64.725 11.791  29.482  1    59.62  ? 273 LYS C C   1 
ATOM   6768 O  O   . LYS C 1 277 ? -64.874 12.36   28.407  1    63.38  ? 273 LYS C O   1 
ATOM   6769 C  CB  . LYS C 1 277 ? -66.972 11.808  30.598  1    70.74  ? 273 LYS C CB  1 
ATOM   6770 C  CG  . LYS C 1 277 ? -67.995 11.062  31.43   1    85.23  ? 273 LYS C CG  1 
ATOM   6771 C  CD  . LYS C 1 277 ? -69.102 10.392  30.623  1    91.65  ? 273 LYS C CD  1 
ATOM   6772 C  CE  . LYS C 1 277 ? -70.467 11.057  30.749  1    93.49  ? 273 LYS C CE  1 
ATOM   6773 N  NZ  . LYS C 1 277 ? -70.382 12.495  30.48   1    94.37  ? 273 LYS C NZ  1 
ATOM   6774 N  N   . ARG C 1 278 ? -63.623 11.914  30.245  1    53.46  ? 274 ARG C N   1 
ATOM   6775 C  CA  . ARG C 1 278 ? -62.462 12.71   29.874  1    49.97  ? 274 ARG C CA  1 
ATOM   6776 C  C   . ARG C 1 278 ? -61.945 12.258  28.503  1    50.89  ? 274 ARG C C   1 
ATOM   6777 O  O   . ARG C 1 278 ? -61.823 11.069  28.243  1    52.8   ? 274 ARG C O   1 
ATOM   6778 C  CB  . ARG C 1 278 ? -61.374 12.548  30.948  1    47.83  ? 274 ARG C CB  1 
ATOM   6779 C  CG  . ARG C 1 278 ? -60.392 13.697  31.098  1    44.87  ? 274 ARG C CG  1 
ATOM   6780 C  CD  . ARG C 1 278 ? -59.496 13.561  32.318  1    45.38  ? 274 ARG C CD  1 
ATOM   6781 N  NE  . ARG C 1 278 ? -60.214 13.595  33.598  1    47.75  ? 274 ARG C NE  1 
ATOM   6782 C  CZ  . ARG C 1 278 ? -59.892 12.916  34.699  1    46.72  ? 274 ARG C CZ  1 
ATOM   6783 N  NH1 . ARG C 1 278 ? -58.786 12.198  34.748  1    43     ? 274 ARG C NH1 1 
ATOM   6784 N  NH2 . ARG C 1 278 ? -60.683 12.971  35.756  1    48.06  ? 274 ARG C NH2 1 
ATOM   6785 N  N   . ILE C 1 279 ? -61.617 13.217  27.638  1    51.3   ? 275 ILE C N   1 
ATOM   6786 C  CA  . ILE C 1 279 ? -61.207 12.937  26.274  1    50.66  ? 275 ILE C CA  1 
ATOM   6787 C  C   . ILE C 1 279 ? -59.887 12.175  26.305  1    53.33  ? 275 ILE C C   1 
ATOM   6788 O  O   . ILE C 1 279 ? -59.058 12.394  27.181  1    57.26  ? 275 ILE C O   1 
ATOM   6789 C  CB  . ILE C 1 279 ? -61.101 14.24   25.465  1    51.27  ? 275 ILE C CB  1 
ATOM   6790 C  CG1 . ILE C 1 279 ? -61.023 13.975  23.955  1    53.29  ? 275 ILE C CG1 1 
ATOM   6791 C  CG2 . ILE C 1 279 ? -59.94  15.116  25.96   1    51.49  ? 275 ILE C CG2 1 
ATOM   6792 C  CD1 . ILE C 1 279 ? -61.147 15.227  23.09   1    51.46  ? 275 ILE C CD1 1 
ATOM   6793 N  N   . SER C 1 280 ? -59.712 11.252  25.352  1    56.41  ? 276 SER C N   1 
ATOM   6794 C  CA  . SER C 1 280 ? -58.446 10.566  25.154  1    54.29  ? 276 SER C CA  1 
ATOM   6795 C  C   . SER C 1 280 ? -57.505 11.456  24.34   1    54.93  ? 276 SER C C   1 
ATOM   6796 O  O   . SER C 1 280 ? -57.985 12.329  23.61   1    54.73  ? 276 SER C O   1 
ATOM   6797 C  CB  . SER C 1 280 ? -58.666 9.287   24.431  1    55.64  ? 276 SER C CB  1 
ATOM   6798 O  OG  . SER C 1 280 ? -59.007 9.568   23.085  1    56.87  ? 276 SER C OG  1 
ATOM   6799 N  N   . ALA C 1 281 ? -56.185 11.201  24.442  1    49.62  ? 277 ALA C N   1 
ATOM   6800 C  CA  . ALA C 1 281 ? -55.199 11.922  23.656  1    50.62  ? 277 ALA C CA  1 
ATOM   6801 C  C   . ALA C 1 281 ? -55.481 11.745  22.163  1    52.45  ? 277 ALA C C   1 
ATOM   6802 O  O   . ALA C 1 281 ? -55.394 12.684  21.38   1    53.26  ? 277 ALA C O   1 
ATOM   6803 C  CB  . ALA C 1 281 ? -53.809 11.473  24.012  1    44.78  ? 277 ALA C CB  1 
ATOM   6804 N  N   . LYS C 1 282 ? -55.839 10.518  21.786  1    53.75  ? 278 LYS C N   1 
ATOM   6805 C  CA  . LYS C 1 282 ? -56.209 10.165  20.425  1    55.42  ? 278 LYS C CA  1 
ATOM   6806 C  C   . LYS C 1 282 ? -57.358 11.043  19.913  1    59.44  ? 278 LYS C C   1 
ATOM   6807 O  O   . LYS C 1 282 ? -57.229 11.664  18.867  1    66.67  ? 278 LYS C O   1 
ATOM   6808 C  CB  . LYS C 1 282 ? -56.564 8.675   20.472  1    55.98  ? 278 LYS C CB  1 
ATOM   6809 C  CG  . LYS C 1 282 ? -56.628 7.96    19.159  1    63.27  ? 278 LYS C CG  1 
ATOM   6810 C  CD  . LYS C 1 282 ? -56.799 6.446   19.272  1    70.28  ? 278 LYS C CD  1 
ATOM   6811 C  CE  . LYS C 1 282 ? -55.574 5.605   19.492  1    66.73  ? 278 LYS C CE  1 
ATOM   6812 N  NZ  . LYS C 1 282 ? -55.819 4.222   19.045  1    65.81  ? 278 LYS C NZ  1 
ATOM   6813 N  N   . ALA C 1 283 ? -58.49  11.09   20.634  1    58.3   ? 279 ALA C N   1 
ATOM   6814 C  CA  . ALA C 1 283 ? -59.644 11.903  20.256  1    59.02  ? 279 ALA C CA  1 
ATOM   6815 C  C   . ALA C 1 283 ? -59.284 13.388  20.208  1    63.69  ? 279 ALA C C   1 
ATOM   6816 O  O   . ALA C 1 283 ? -59.678 14.095  19.271  1    69.84  ? 279 ALA C O   1 
ATOM   6817 C  CB  . ALA C 1 283 ? -60.809 11.657  21.194  1    53.08  ? 279 ALA C CB  1 
ATOM   6818 N  N   . ALA C 1 284 ? -58.547 13.851  21.231  1    56.56  ? 280 ALA C N   1 
ATOM   6819 C  CA  . ALA C 1 284 ? -58.141 15.24   21.339  1    58.61  ? 280 ALA C CA  1 
ATOM   6820 C  C   . ALA C 1 284 ? -57.334 15.713  20.124  1    64.67  ? 280 ALA C C   1 
ATOM   6821 O  O   . ALA C 1 284 ? -57.318 16.905  19.836  1    78.49  ? 280 ALA C O   1 
ATOM   6822 C  CB  . ALA C 1 284 ? -57.404 15.454  22.637  1    56.55  ? 280 ALA C CB  1 
ATOM   6823 N  N   . LEU C 1 285 ? -56.659 14.796  19.411  1    63.4   ? 281 LEU C N   1 
ATOM   6824 C  CA  . LEU C 1 285 ? -55.901 15.135  18.209  1    62.42  ? 281 LEU C CA  1 
ATOM   6825 C  C   . LEU C 1 285 ? -56.833 15.487  17.041  1    65.61  ? 281 LEU C C   1 
ATOM   6826 O  O   . LEU C 1 285 ? -56.455 16.232  16.134  1    65.63  ? 281 LEU C O   1 
ATOM   6827 C  CB  . LEU C 1 285 ? -55.003 13.957  17.833  1    62.71  ? 281 LEU C CB  1 
ATOM   6828 C  CG  . LEU C 1 285 ? -53.793 13.679  18.729  1    61.52  ? 281 LEU C CG  1 
ATOM   6829 C  CD1 . LEU C 1 285 ? -53.077 12.418  18.273  1    55.72  ? 281 LEU C CD1 1 
ATOM   6830 C  CD2 . LEU C 1 285 ? -52.82  14.871  18.754  1    60.47  ? 281 LEU C CD2 1 
ATOM   6831 N  N   . ALA C 1 286 ? -58.045 14.919  17.052  1    67.58  ? 282 ALA C N   1 
ATOM   6832 C  CA  . ALA C 1 286 ? -59.068 15.225  16.062  1    69.09  ? 282 ALA C CA  1 
ATOM   6833 C  C   . ALA C 1 286 ? -59.749 16.565  16.358  1    74.2   ? 282 ALA C C   1 
ATOM   6834 O  O   . ALA C 1 286 ? -60.346 17.143  15.459  1    73.81  ? 282 ALA C O   1 
ATOM   6835 C  CB  . ALA C 1 286 ? -60.087 14.106  16      1    63.34  ? 282 ALA C CB  1 
ATOM   6836 N  N   . HIS C 1 287 ? -59.652 17.065  17.605  1    73.71  ? 283 HIS C N   1 
ATOM   6837 C  CA  . HIS C 1 287 ? -60.471 18.197  18.033  1    67.88  ? 283 HIS C CA  1 
ATOM   6838 C  C   . HIS C 1 287 ? -60.321 19.404  17.097  1    67.02  ? 283 HIS C C   1 
ATOM   6839 O  O   . HIS C 1 287 ? -59.226 19.686  16.615  1    67.44  ? 283 HIS C O   1 
ATOM   6840 C  CB  . HIS C 1 287 ? -60.203 18.539  19.499  1    61.78  ? 283 HIS C CB  1 
ATOM   6841 C  CG  . HIS C 1 287 ? -61.211 19.476  20.058  1    64.39  ? 283 HIS C CG  1 
ATOM   6842 N  ND1 . HIS C 1 287 ? -61.253 20.801  19.682  1    65.77  ? 283 HIS C ND1 1 
ATOM   6843 C  CD2 . HIS C 1 287 ? -62.233 19.303  20.914  1    64.82  ? 283 HIS C CD2 1 
ATOM   6844 C  CE1 . HIS C 1 287 ? -62.268 21.406  20.299  1    66.83  ? 283 HIS C CE1 1 
ATOM   6845 N  NE2 . HIS C 1 287 ? -62.866 20.519  21.056  1    67.09  ? 283 HIS C NE2 1 
ATOM   6846 N  N   . PRO C 1 288 ? -61.425 20.12   16.771  1    66.11  ? 284 PRO C N   1 
ATOM   6847 C  CA  . PRO C 1 288 ? -61.385 21.287  15.88   1    68.77  ? 284 PRO C CA  1 
ATOM   6848 C  C   . PRO C 1 288 ? -60.325 22.337  16.195  1    68.11  ? 284 PRO C C   1 
ATOM   6849 O  O   . PRO C 1 288 ? -59.926 23.101  15.323  1    74.21  ? 284 PRO C O   1 
ATOM   6850 C  CB  . PRO C 1 288 ? -62.811 21.89   15.969  1    65.88  ? 284 PRO C CB  1 
ATOM   6851 C  CG  . PRO C 1 288 ? -63.671 20.697  16.3    1    65.66  ? 284 PRO C CG  1 
ATOM   6852 C  CD  . PRO C 1 288 ? -62.805 19.81   17.186  1    65.76  ? 284 PRO C CD  1 
ATOM   6853 N  N   . PHE C 1 289 ? -59.877 22.383  17.447  1    64.3   ? 285 PHE C N   1 
ATOM   6854 C  CA  . PHE C 1 289 ? -58.876 23.363  17.842  1    66.56  ? 285 PHE C CA  1 
ATOM   6855 C  C   . PHE C 1 289 ? -57.626 23.275  16.955  1    65.07  ? 285 PHE C C   1 
ATOM   6856 O  O   . PHE C 1 289 ? -56.943 24.281  16.767  1    62.81  ? 285 PHE C O   1 
ATOM   6857 C  CB  . PHE C 1 289 ? -58.589 23.146  19.33   1    61.25  ? 285 PHE C CB  1 
ATOM   6858 C  CG  . PHE C 1 289 ? -57.552 24.079  19.926  1    59.46  ? 285 PHE C CG  1 
ATOM   6859 C  CD1 . PHE C 1 289 ? -57.797 25.438  20.019  1    60.99  ? 285 PHE C CD1 1 
ATOM   6860 C  CD2 . PHE C 1 289 ? -56.345 23.584  20.404  1    59.71  ? 285 PHE C CD2 1 
ATOM   6861 C  CE1 . PHE C 1 289 ? -56.861 26.282  20.591  1    61.3   ? 285 PHE C CE1 1 
ATOM   6862 C  CE2 . PHE C 1 289 ? -55.41  24.423  20.969  1    58.65  ? 285 PHE C CE2 1 
ATOM   6863 C  CZ  . PHE C 1 289 ? -55.674 25.77   21.06   1    62.64  ? 285 PHE C CZ  1 
ATOM   6864 N  N   . PHE C 1 290 ? -57.358 22.078  16.405  1    64     ? 286 PHE C N   1 
ATOM   6865 C  CA  . PHE C 1 290 ? -56.098 21.725  15.761  1    66.87  ? 286 PHE C CA  1 
ATOM   6866 C  C   . PHE C 1 290 ? -56.186 21.764  14.229  1    72     ? 286 PHE C C   1 
ATOM   6867 O  O   . PHE C 1 290 ? -55.154 21.663  13.557  1    70.01  ? 286 PHE C O   1 
ATOM   6868 C  CB  . PHE C 1 290 ? -55.663 20.33   16.217  1    60.26  ? 286 PHE C CB  1 
ATOM   6869 C  CG  . PHE C 1 290 ? -55.235 20.289  17.672  1    61.8   ? 286 PHE C CG  1 
ATOM   6870 C  CD1 . PHE C 1 290 ? -54.223 21.134  18.146  1    58.88  ? 286 PHE C CD1 1 
ATOM   6871 C  CD2 . PHE C 1 290 ? -55.849 19.399  18.555  1    59.65  ? 286 PHE C CD2 1 
ATOM   6872 C  CE1 . PHE C 1 290 ? -53.834 21.079  19.474  1    57.89  ? 286 PHE C CE1 1 
ATOM   6873 C  CE2 . PHE C 1 290 ? -55.439 19.35   19.884  1    60.5   ? 286 PHE C CE2 1 
ATOM   6874 C  CZ  . PHE C 1 290 ? -54.447 20.198  20.344  1    56.62  ? 286 PHE C CZ  1 
ATOM   6875 N  N   . GLN C 1 291 ? -57.401 21.912  13.687  1    74.04  ? 287 GLN C N   1 
ATOM   6876 C  CA  . GLN C 1 291 ? -57.627 21.941  12.25   1    84.55  ? 287 GLN C CA  1 
ATOM   6877 C  C   . GLN C 1 291 ? -56.557 22.784  11.541  1    82.38  ? 287 GLN C C   1 
ATOM   6878 O  O   . GLN C 1 291 ? -56.191 22.482  10.409  1    87.16  ? 287 GLN C O   1 
ATOM   6879 C  CB  . GLN C 1 291 ? -59.062 22.372  11.927  1    91.11  ? 287 GLN C CB  1 
ATOM   6880 C  CG  . GLN C 1 291 ? -59.328 23.842  12.252  1    107.98 ? 287 GLN C CG  1 
ATOM   6881 C  CD  . GLN C 1 291 ? -60.773 24.277  12.08   1    122.12 ? 287 GLN C CD  1 
ATOM   6882 O  OE1 . GLN C 1 291 ? -61.14  25.438  12.316  1    112.72 ? 287 GLN C OE1 1 
ATOM   6883 N  NE2 . GLN C 1 291 ? -61.612 23.337  11.663  1    130.4  ? 287 GLN C NE2 1 
ATOM   6884 N  N   . ASP C 1 292 ? -56.065 23.843  12.197  1    80.2   ? 288 ASP C N   1 
ATOM   6885 C  CA  . ASP C 1 292 ? -55.175 24.811  11.566  1    79.01  ? 288 ASP C CA  1 
ATOM   6886 C  C   . ASP C 1 292 ? -53.853 24.886  12.327  1    78.67  ? 288 ASP C C   1 
ATOM   6887 O  O   . ASP C 1 292 ? -53.185 25.924  12.322  1    80.46  ? 288 ASP C O   1 
ATOM   6888 C  CB  . ASP C 1 292 ? -55.784 26.206  11.547  1    84.42  ? 288 ASP C CB  1 
ATOM   6889 C  CG  . ASP C 1 292 ? -56.121 26.788  12.914  1    85.2   ? 288 ASP C CG  1 
ATOM   6890 O  OD1 . ASP C 1 292 ? -56.145 26.02   13.905  1    82.42  ? 288 ASP C OD1 1 
ATOM   6891 O  OD2 . ASP C 1 292 ? -56.36  28.009  12.976  1    86.69  ? 288 ASP C OD2 1 
ATOM   6892 N  N   . VAL C 1 293 ? -53.465 23.782  12.981  1    72.6   ? 289 VAL C N   1 
ATOM   6893 C  CA  . VAL C 1 293 ? -52.199 23.752  13.699  1    65.83  ? 289 VAL C CA  1 
ATOM   6894 C  C   . VAL C 1 293 ? -51.054 23.93   12.695  1    68.52  ? 289 VAL C C   1 
ATOM   6895 O  O   . VAL C 1 293 ? -51.115 23.424  11.573  1    72.73  ? 289 VAL C O   1 
ATOM   6896 C  CB  . VAL C 1 293 ? -52.049 22.485  14.563  1    59.62  ? 289 VAL C CB  1 
ATOM   6897 C  CG1 . VAL C 1 293 ? -52.07  21.222  13.722  1    58.68  ? 289 VAL C CG1 1 
ATOM   6898 C  CG2 . VAL C 1 293 ? -50.794 22.535  15.419  1    54.98  ? 289 VAL C CG2 1 
ATOM   6899 N  N   . THR C 1 294 ? -50.038 24.71   13.097  1    65.6   ? 290 THR C N   1 
ATOM   6900 C  CA  . THR C 1 294 ? -48.772 24.831  12.383  1    64.38  ? 290 THR C CA  1 
ATOM   6901 C  C   . THR C 1 294 ? -47.647 24.464  13.353  1    62.27  ? 290 THR C C   1 
ATOM   6902 O  O   . THR C 1 294 ? -47.91  24.033  14.464  1    62.35  ? 290 THR C O   1 
ATOM   6903 C  CB  . THR C 1 294 ? -48.597 26.23   11.782  1    66.33  ? 290 THR C CB  1 
ATOM   6904 O  OG1 . THR C 1 294 ? -48.599 27.188  12.844  1    66.45  ? 290 THR C OG1 1 
ATOM   6905 C  CG2 . THR C 1 294 ? -49.688 26.579  10.785  1    66.32  ? 290 THR C CG2 1 
ATOM   6906 N  N   . LYS C 1 295 ? -46.392 24.609  12.924  1    65.61  ? 291 LYS C N   1 
ATOM   6907 C  CA  . LYS C 1 295 ? -45.228 24.339  13.755  1    62.96  ? 291 LYS C CA  1 
ATOM   6908 C  C   . LYS C 1 295 ? -44.331 25.579  13.802  1    63.91  ? 291 LYS C C   1 
ATOM   6909 O  O   . LYS C 1 295 ? -43.274 25.609  13.157  1    64.51  ? 291 LYS C O   1 
ATOM   6910 C  CB  . LYS C 1 295 ? -44.432 23.134  13.229  1    67.41  ? 291 LYS C CB  1 
ATOM   6911 C  CG  . LYS C 1 295 ? -43.387 22.577  14.196  1    66.6   ? 291 LYS C CG  1 
ATOM   6912 C  CD  . LYS C 1 295 ? -42.338 21.613  13.653  1    69.05  ? 291 LYS C CD  1 
ATOM   6913 C  CE  . LYS C 1 295 ? -41.665 20.937  14.821  1    75.96  ? 291 LYS C CE  1 
ATOM   6914 N  NZ  . LYS C 1 295 ? -40.358 20.375  14.471  1    76.34  ? 291 LYS C NZ  1 
ATOM   6915 N  N   . PRO C 1 296 ? -44.698 26.631  14.581  1    60.7   ? 292 PRO C N   1 
ATOM   6916 C  CA  . PRO C 1 296 ? -43.869 27.838  14.676  1    60.35  ? 292 PRO C CA  1 
ATOM   6917 C  C   . PRO C 1 296 ? -42.583 27.547  15.456  1    61.62  ? 292 PRO C C   1 
ATOM   6918 O  O   . PRO C 1 296 ? -42.508 26.55   16.168  1    59.16  ? 292 PRO C O   1 
ATOM   6919 C  CB  . PRO C 1 296 ? -44.76  28.874  15.376  1    57.38  ? 292 PRO C CB  1 
ATOM   6920 C  CG  . PRO C 1 296 ? -46.123 28.207  15.542  1    56.63  ? 292 PRO C CG  1 
ATOM   6921 C  CD  . PRO C 1 296 ? -45.907 26.705  15.416  1    56.17  ? 292 PRO C CD  1 
ATOM   6922 N  N   . VAL C 1 297 ? -41.57  28.399  15.279  1    62.98  ? 293 VAL C N   1 
ATOM   6923 C  CA  . VAL C 1 297 ? -40.351 28.301  16.068  1    67.38  ? 293 VAL C CA  1 
ATOM   6924 C  C   . VAL C 1 297 ? -40.527 29.16   17.32   1    65.77  ? 293 VAL C C   1 
ATOM   6925 O  O   . VAL C 1 297 ? -41.124 30.227  17.252  1    72.68  ? 293 VAL C O   1 
ATOM   6926 C  CB  . VAL C 1 297 ? -39.079 28.667  15.263  1    61.88  ? 293 VAL C CB  1 
ATOM   6927 C  CG1 . VAL C 1 297 ? -38.632 27.545  14.349  1    56.04  ? 293 VAL C CG1 1 
ATOM   6928 C  CG2 . VAL C 1 297 ? -39.266 29.926  14.451  1    63.84  ? 293 VAL C CG2 1 
ATOM   6929 N  N   . PRO C 1 298 ? -39.994 28.753  18.5    1    65.42  ? 294 PRO C N   1 
ATOM   6930 C  CA  . PRO C 1 298 ? -40.086 29.601  19.672  1    65.33  ? 294 PRO C CA  1 
ATOM   6931 C  C   . PRO C 1 298 ? -39.089 30.739  19.631  1    69.68  ? 294 PRO C C   1 
ATOM   6932 O  O   . PRO C 1 298 ? -38.04  30.641  18.974  1    67.19  ? 294 PRO C O   1 
ATOM   6933 C  CB  . PRO C 1 298 ? -39.764 28.603  20.776  1    58.33  ? 294 PRO C CB  1 
ATOM   6934 C  CG  . PRO C 1 298 ? -38.699 27.734  20.182  1    60.24  ? 294 PRO C CG  1 
ATOM   6935 C  CD  . PRO C 1 298 ? -39.271 27.501  18.806  1    61.54  ? 294 PRO C CD  1 
ATOM   6936 N  N   . HIS C 1 299 ? -39.408 31.825  20.322  1    77.04  ? 295 HIS C N   1 
ATOM   6937 C  CA  . HIS C 1 299 ? -38.441 32.945  20.413  1    92.63  ? 295 HIS C CA  1 
ATOM   6938 C  C   . HIS C 1 299 ? -37.636 32.745  21.693  1    100.2  ? 295 HIS C C   1 
ATOM   6939 O  O   . HIS C 1 299 ? -38.14  33.096  22.776  1    108.02 ? 295 HIS C O   1 
ATOM   6940 C  CB  . HIS C 1 299 ? -39.171 34.285  20.354  1    104.21 ? 295 HIS C CB  1 
ATOM   6941 C  CG  . HIS C 1 299 ? -39.215 34.838  18.973  1    125.93 ? 295 HIS C CG  1 
ATOM   6942 N  ND1 . HIS C 1 299 ? -39.262 34.022  17.864  1    123.22 ? 295 HIS C ND1 1 
ATOM   6943 C  CD2 . HIS C 1 299 ? -39.205 36.092  18.513  1    133.08 ? 295 HIS C CD2 1 
ATOM   6944 C  CE1 . HIS C 1 299 ? -39.285 34.772  16.774  1    131.75 ? 295 HIS C CE1 1 
ATOM   6945 N  NE2 . HIS C 1 299 ? -39.252 36.033  17.145  1    141.57 ? 295 HIS C NE2 1 
ATOM   6946 N  N   . LEU C 1 300 ? -36.43  32.193  21.57   1    97.69  ? 296 LEU C N   1 
ATOM   6947 C  CA  . LEU C 1 300 ? -35.648 31.864  22.784  1    98.27  ? 296 LEU C CA  1 
ATOM   6948 C  C   . LEU C 1 300 ? -34.145 32.042  22.52   1    95.33  ? 296 LEU C C   1 
ATOM   6949 O  O   . LEU C 1 300 ? -33.435 32.395  23.486  1    83.67  ? 296 LEU C O   1 
ATOM   6950 C  CB  . LEU C 1 300 ? -36.013 30.426  23.147  1    102.56 ? 296 LEU C CB  1 
ATOM   6951 C  CG  . LEU C 1 300 ? -35.67  29.35   22.113  1    101.97 ? 296 LEU C CG  1 
ATOM   6952 C  CD1 . LEU C 1 300 ? -36.003 29.854  20.72   1    100.4  ? 296 LEU C CD1 1 
ATOM   6953 C  CD2 . LEU C 1 300 ? -34.203 28.984  22.201  1    88.38  ? 296 LEU C CD2 1 
ATOM   6954 N  N   . GLY D 2 1   ? -65.048 1.068   31.24   1    78.98  ? 171 GLY D N   1 
ATOM   6955 C  CA  . GLY D 2 1   ? -64.789 2.503   30.96   1    77.81  ? 171 GLY D CA  1 
ATOM   6956 C  C   . GLY D 2 1   ? -63.297 2.708   30.716  1    78.61  ? 171 GLY D C   1 
ATOM   6957 O  O   . GLY D 2 1   ? -62.709 1.879   30.028  1    78.57  ? 171 GLY D O   1 
ATOM   6958 N  N   . VAL D 2 2   ? -62.688 3.746   31.319  1    75.76  ? 172 VAL D N   1 
ATOM   6959 C  CA  . VAL D 2 2   ? -61.321 4.13    30.986  1    71.91  ? 172 VAL D CA  1 
ATOM   6960 C  C   . VAL D 2 2   ? -60.309 3.13    31.557  1    70.06  ? 172 VAL D C   1 
ATOM   6961 O  O   . VAL D 2 2   ? -59.203 2.978   31.011  1    63.02  ? 172 VAL D O   1 
ATOM   6962 C  CB  . VAL D 2 2   ? -60.988 5.577   31.394  1    71.01  ? 172 VAL D CB  1 
ATOM   6963 C  CG1 . VAL D 2 2   ? -60.748 5.706   32.897  1    67.4   ? 172 VAL D CG1 1 
ATOM   6964 C  CG2 . VAL D 2 2   ? -59.806 6.118   30.59   1    67.82  ? 172 VAL D CG2 1 
ATOM   6965 N  N   . ASN D 2 3   ? -60.717 2.427   32.629  1    67.4   ? 173 ASN D N   1 
ATOM   6966 C  CA  . ASN D 2 3   ? -59.948 1.327   33.202  1    63.78  ? 173 ASN D CA  1 
ATOM   6967 C  C   . ASN D 2 3   ? -59.707 0.191   32.2    1    59.64  ? 173 ASN D C   1 
ATOM   6968 O  O   . ASN D 2 3   ? -58.827 -0.637  32.402  1    55.13  ? 173 ASN D O   1 
ATOM   6969 C  CB  . ASN D 2 3   ? -60.6   0.81    34.478  1    66.87  ? 173 ASN D CB  1 
ATOM   6970 C  CG  . ASN D 2 3   ? -60.538 1.83    35.583  1    69.66  ? 173 ASN D CG  1 
ATOM   6971 O  OD1 . ASN D 2 3   ? -59.785 2.8     35.485  1    72.31  ? 173 ASN D OD1 1 
ATOM   6972 N  ND2 . ASN D 2 3   ? -61.322 1.646   36.633  1    75.99  ? 173 ASN D ND2 1 
ATOM   6973 N  N   . GLU D 2 4   ? -60.497 0.145   31.125  1    64.31  ? 174 GLU D N   1 
ATOM   6974 C  CA  . GLU D 2 4   ? -60.286 -0.854  30.091  1    69.49  ? 174 GLU D CA  1 
ATOM   6975 C  C   . GLU D 2 4   ? -59.78  -0.206  28.803  1    72.21  ? 174 GLU D C   1 
ATOM   6976 O  O   . GLU D 2 4   ? -59.785 -0.857  27.758  1    70.29  ? 174 GLU D O   1 
ATOM   6977 C  CB  . GLU D 2 4   ? -61.582 -1.618  29.829  1    73.47  ? 174 GLU D CB  1 
ATOM   6978 C  CG  . GLU D 2 4   ? -62.105 -2.345  31.064  1    74.58  ? 174 GLU D CG  1 
ATOM   6979 C  CD  . GLU D 2 4   ? -63.533 -2.824  30.924  1    80.21  ? 174 GLU D CD  1 
ATOM   6980 O  OE1 . GLU D 2 4   ? -64.228 -2.384  29.975  1    84.06  ? 174 GLU D OE1 1 
ATOM   6981 O  OE2 . GLU D 2 4   ? -63.918 -3.669  31.761  1    84.77  ? 174 GLU D OE2 1 
ATOM   6982 N  N   . VAL D 2 5   ? -59.365 1.073   28.901  1    71.48  ? 175 VAL D N   1 
ATOM   6983 C  CA  . VAL D 2 5   ? -58.688 1.835   27.854  1    65.64  ? 175 VAL D CA  1 
ATOM   6984 C  C   . VAL D 2 5   ? -59.286 1.523   26.475  1    66.33  ? 175 VAL D C   1 
ATOM   6985 O  O   . VAL D 2 5   ? -58.609 1       25.587  1    61.86  ? 175 VAL D O   1 
ATOM   6986 C  CB  . VAL D 2 5   ? -57.154 1.641   27.917  1    61.92  ? 175 VAL D CB  1 
ATOM   6987 C  CG1 . VAL D 2 5   ? -56.524 2.37    29.107  1    55.43  ? 175 VAL D CG1 1 
ATOM   6988 C  CG2 . VAL D 2 5   ? -56.755 0.167   27.891  1    57     ? 175 VAL D CG2 1 
ATOM   6989 N  N   . PRO D 2 6   ? -60.587 1.831   26.258  1    66.14  ? 176 PRO D N   1 
ATOM   6990 C  CA  . PRO D 2 6   ? -61.262 1.601   24.988  1    64.23  ? 176 PRO D CA  1 
ATOM   6991 C  C   . PRO D 2 6   ? -60.548 2.119   23.75   1    64.51  ? 176 PRO D C   1 
ATOM   6992 O  O   . PRO D 2 6   ? -60.537 1.449   22.725  1    69.52  ? 176 PRO D O   1 
ATOM   6993 C  CB  . PRO D 2 6   ? -62.621 2.321   25.126  1    66.26  ? 176 PRO D CB  1 
ATOM   6994 C  CG  . PRO D 2 6   ? -62.61  3.026   26.455  1    65.06  ? 176 PRO D CG  1 
ATOM   6995 C  CD  . PRO D 2 6   ? -61.506 2.389   27.264  1    71.9   ? 176 PRO D CD  1 
ATOM   6996 N  N   . ASP D 2 7   ? -59.991 3.323   23.834  1    63.74  ? 177 ASP D N   1 
ATOM   6997 C  CA  . ASP D 2 7   ? -59.363 3.924   22.674  1    63.52  ? 177 ASP D CA  1 
ATOM   6998 C  C   . ASP D 2 7   ? -57.99  3.321   22.372  1    63.15  ? 177 ASP D C   1 
ATOM   6999 O  O   . ASP D 2 7   ? -57.371 3.765   21.401  1    65.51  ? 177 ASP D O   1 
ATOM   7000 C  CB  . ASP D 2 7   ? -59.243 5.426   22.855  1    66.41  ? 177 ASP D CB  1 
ATOM   7001 C  CG  . ASP D 2 7   ? -60.563 6.153   22.737  1    72.91  ? 177 ASP D CG  1 
ATOM   7002 O  OD1 . ASP D 2 7   ? -61.488 5.505   22.196  1    77.33  ? 177 ASP D OD1 1 
ATOM   7003 O  OD2 . ASP D 2 7   ? -60.652 7.325   23.198  1    72.51  ? 177 ASP D OD2 1 
ATOM   7004 N  N   . TYR D 2 8   ? -57.523 2.346   23.187  1    56.69  ? 178 TYR D N   1 
ATOM   7005 C  CA  . TYR D 2 8   ? -56.152 1.853   23.132  1    55.45  ? 178 TYR D CA  1 
ATOM   7006 C  C   . TYR D 2 8   ? -56.05  0.321   23.094  1    60.45  ? 178 TYR D C   1 
ATOM   7007 O  O   . TYR D 2 8   ? -55.007 -0.195  22.668  1    60.33  ? 178 TYR D O   1 
ATOM   7008 C  CB  . TYR D 2 8   ? -55.277 2.441   24.251  1    49.45  ? 178 TYR D CB  1 
ATOM   7009 C  CG  . TYR D 2 8   ? -55.118 3.938   24.107  1    49.29  ? 178 TYR D CG  1 
ATOM   7010 C  CD1 . TYR D 2 8   ? -54.403 4.478   23.05   1    49.24  ? 178 TYR D CD1 1 
ATOM   7011 C  CD2 . TYR D 2 8   ? -55.769 4.802   24.97   1    51.7   ? 178 TYR D CD2 1 
ATOM   7012 C  CE1 . TYR D 2 8   ? -54.303 5.843   22.875  1    52.61  ? 178 TYR D CE1 1 
ATOM   7013 C  CE2 . TYR D 2 8   ? -55.682 6.172   24.801  1    53.44  ? 178 TYR D CE2 1 
ATOM   7014 C  CZ  . TYR D 2 8   ? -54.95  6.699   23.752  1    56.02  ? 178 TYR D CZ  1 
ATOM   7015 O  OH  . TYR D 2 8   ? -54.89  8.073   23.591  1    60.45  ? 178 TYR D OH  1 
ATOM   7016 N  N   . HIS D 2 9   ? -57.091 -0.406  23.543  1    64.03  ? 179 HIS D N   1 
ATOM   7017 C  CA  . HIS D 2 9   ? -56.997 -1.856  23.741  1    67.71  ? 179 HIS D CA  1 
ATOM   7018 C  C   . HIS D 2 9   ? -56.429 -2.539  22.485  1    66.3   ? 179 HIS D C   1 
ATOM   7019 O  O   . HIS D 2 9   ? -55.548 -3.394  22.588  1    61.63  ? 179 HIS D O   1 
ATOM   7020 C  CB  . HIS D 2 9   ? -58.278 -2.47   24.339  1    68.05  ? 179 HIS D CB  1 
ATOM   7021 C  CG  . HIS D 2 9   ? -59.386 -2.694  23.346  1    84.57  ? 179 HIS D CG  1 
ATOM   7022 N  ND1 . HIS D 2 9   ? -60.464 -1.835  23.214  1    94.74  ? 179 HIS D ND1 1 
ATOM   7023 C  CD2 . HIS D 2 9   ? -59.586 -3.669  22.42   1    86.75  ? 179 HIS D CD2 1 
ATOM   7024 C  CE1 . HIS D 2 9   ? -61.278 -2.28   22.252  1    97.84  ? 179 HIS D CE1 1 
ATOM   7025 N  NE2 . HIS D 2 9   ? -60.756 -3.384  21.747  1    90.68  ? 179 HIS D NE2 1 
ATOM   7026 N  N   . GLU D 2 10  ? -56.884 -2.106  21.299  1    63.95  ? 180 GLU D N   1 
ATOM   7027 C  CA  . GLU D 2 10  ? -56.434 -2.712  20.056  1    68.44  ? 180 GLU D CA  1 
ATOM   7028 C  C   . GLU D 2 10  ? -54.958 -2.417  19.781  1    64.73  ? 180 GLU D C   1 
ATOM   7029 O  O   . GLU D 2 10  ? -54.175 -3.336  19.532  1    67.54  ? 180 GLU D O   1 
ATOM   7030 C  CB  . GLU D 2 10  ? -57.255 -2.268  18.853  1    76.97  ? 180 GLU D CB  1 
ATOM   7031 C  CG  . GLU D 2 10  ? -58.739 -2.574  19.015  1    96.92  ? 180 GLU D CG  1 
ATOM   7032 C  CD  . GLU D 2 10  ? -59.403 -2.752  17.664  1    109.42 ? 180 GLU D CD  1 
ATOM   7033 O  OE1 . GLU D 2 10  ? -59.08  -1.997  16.706  1    105.68 ? 180 GLU D OE1 1 
ATOM   7034 O  OE2 . GLU D 2 10  ? -60.259 -3.67   17.609  1    118.76 ? 180 GLU D OE2 1 
ATOM   7035 N  N   . ASP D 2 11  ? -54.594 -1.13   19.791  1    57.7   ? 181 ASP D N   1 
ATOM   7036 C  CA  . ASP D 2 11  ? -53.207 -0.749  19.604  1    56.49  ? 181 ASP D CA  1 
ATOM   7037 C  C   . ASP D 2 11  ? -52.326 -1.493  20.609  1    58.64  ? 181 ASP D C   1 
ATOM   7038 O  O   . ASP D 2 11  ? -51.245 -1.953  20.233  1    59.92  ? 181 ASP D O   1 
ATOM   7039 C  CB  . ASP D 2 11  ? -53.025 0.752   19.692  1    58.89  ? 181 ASP D CB  1 
ATOM   7040 C  CG  . ASP D 2 11  ? -53.572 1.574   18.527  1    64.68  ? 181 ASP D CG  1 
ATOM   7041 O  OD1 . ASP D 2 11  ? -54.065 0.949   17.545  1    62.23  ? 181 ASP D OD1 1 
ATOM   7042 O  OD2 . ASP D 2 11  ? -53.487 2.841   18.603  1    61.9   ? 181 ASP D OD2 1 
ATOM   7043 N  N   . ILE D 2 12  ? -52.808 -1.64   21.861  1    53.32  ? 182 ILE D N   1 
ATOM   7044 C  CA  . ILE D 2 12  ? -52.025 -2.262  22.918  1    54.61  ? 182 ILE D CA  1 
ATOM   7045 C  C   . ILE D 2 12  ? -51.802 -3.727  22.57   1    52.61  ? 182 ILE D C   1 
ATOM   7046 O  O   . ILE D 2 12  ? -50.663 -4.183  22.607  1    55.57  ? 182 ILE D O   1 
ATOM   7047 C  CB  . ILE D 2 12  ? -52.625 -2.061  24.332  1    51.03  ? 182 ILE D CB  1 
ATOM   7048 C  CG1 . ILE D 2 12  ? -52.413 -0.628  24.837  1    50.38  ? 182 ILE D CG1 1 
ATOM   7049 C  CG2 . ILE D 2 12  ? -52.025 -3.061  25.31   1    45.75  ? 182 ILE D CG2 1 
ATOM   7050 C  CD1 . ILE D 2 12  ? -53.249 -0.217  26.047  1    49.43  ? 182 ILE D CD1 1 
ATOM   7051 N  N   . HIS D 2 13  ? -52.896 -4.44   22.258  1    53.52  ? 183 HIS D N   1 
ATOM   7052 C  CA  . HIS D 2 13  ? -52.891 -5.856  21.868  1    51.71  ? 183 HIS D CA  1 
ATOM   7053 C  C   . HIS D 2 13  ? -51.971 -6.109  20.665  1    50.67  ? 183 HIS D C   1 
ATOM   7054 O  O   . HIS D 2 13  ? -51.102 -6.982  20.715  1    51.74  ? 183 HIS D O   1 
ATOM   7055 C  CB  . HIS D 2 13  ? -54.318 -6.358  21.595  1    51.48  ? 183 HIS D CB  1 
ATOM   7056 C  CG  . HIS D 2 13  ? -54.374 -7.774  21.133  1    53.65  ? 183 HIS D CG  1 
ATOM   7057 N  ND1 . HIS D 2 13  ? -54.348 -8.838  22.013  1    57.83  ? 183 HIS D ND1 1 
ATOM   7058 C  CD2 . HIS D 2 13  ? -54.431 -8.305  19.914  1    53.29  ? 183 HIS D CD2 1 
ATOM   7059 C  CE1 . HIS D 2 13  ? -54.369 -9.976  21.347  1    52.6   ? 183 HIS D CE1 1 
ATOM   7060 N  NE2 . HIS D 2 13  ? -54.418 -9.668  20.073  1    56.38  ? 183 HIS D NE2 1 
ATOM   7061 N  N   . THR D 2 14  ? -52.14  -5.314  19.599  1    49.16  ? 184 THR D N   1 
ATOM   7062 C  CA  . THR D 2 14  ? -51.325 -5.423  18.399  1    53.49  ? 184 THR D CA  1 
ATOM   7063 C  C   . THR D 2 14  ? -49.85  -5.323  18.786  1    57.78  ? 184 THR D C   1 
ATOM   7064 O  O   . THR D 2 14  ? -49.002 -6.009  18.213  1    60.35  ? 184 THR D O   1 
ATOM   7065 C  CB  . THR D 2 14  ? -51.726 -4.347  17.38   1    53.7   ? 184 THR D CB  1 
ATOM   7066 O  OG1 . THR D 2 14  ? -53.018 -4.703  16.892  1    57.43  ? 184 THR D OG1 1 
ATOM   7067 C  CG2 . THR D 2 14  ? -50.765 -4.221  16.209  1    47.74  ? 184 THR D CG2 1 
ATOM   7068 N  N   . TYR D 2 15  ? -49.56  -4.417  19.727  1    57.04  ? 185 TYR D N   1 
ATOM   7069 C  CA  . TYR D 2 15  ? -48.197 -4.146  20.141  1    53.96  ? 185 TYR D CA  1 
ATOM   7070 C  C   . TYR D 2 15  ? -47.665 -5.289  20.997  1    52.66  ? 185 TYR D C   1 
ATOM   7071 O  O   . TYR D 2 15  ? -46.517 -5.663  20.812  1    49.39  ? 185 TYR D O   1 
ATOM   7072 C  CB  . TYR D 2 15  ? -48.111 -2.824  20.91   1    56.66  ? 185 TYR D CB  1 
ATOM   7073 C  CG  . TYR D 2 15  ? -46.71  -2.499  21.411  1    56.49  ? 185 TYR D CG  1 
ATOM   7074 C  CD1 . TYR D 2 15  ? -45.682 -2.207  20.501  1    53.64  ? 185 TYR D CD1 1 
ATOM   7075 C  CD2 . TYR D 2 15  ? -46.416 -2.506  22.778  1    48.53  ? 185 TYR D CD2 1 
ATOM   7076 C  CE1 . TYR D 2 15  ? -44.4   -1.916  20.936  1    50.92  ? 185 TYR D CE1 1 
ATOM   7077 C  CE2 . TYR D 2 15  ? -45.139 -2.21   23.222  1    49.26  ? 185 TYR D CE2 1 
ATOM   7078 C  CZ  . TYR D 2 15  ? -44.139 -1.9    22.301  1    54.5   ? 185 TYR D CZ  1 
ATOM   7079 O  OH  . TYR D 2 15  ? -42.862 -1.607  22.713  1    56.32  ? 185 TYR D OH  1 
ATOM   7080 N  N   . LEU D 2 16  ? -48.47  -5.804  21.942  1    51.05  ? 186 LEU D N   1 
ATOM   7081 C  CA  . LEU D 2 16  ? -48.038 -6.897  22.807  1    49.12  ? 186 LEU D CA  1 
ATOM   7082 C  C   . LEU D 2 16  ? -47.716 -8.116  21.949  1    48.4   ? 186 LEU D C   1 
ATOM   7083 O  O   . LEU D 2 16  ? -46.754 -8.819  22.222  1    43.89  ? 186 LEU D O   1 
ATOM   7084 C  CB  . LEU D 2 16  ? -49.08  -7.255  23.865  1    44.98  ? 186 LEU D CB  1 
ATOM   7085 C  CG  . LEU D 2 16  ? -49.33  -6.198  24.933  1    47.34  ? 186 LEU D CG  1 
ATOM   7086 C  CD1 . LEU D 2 16  ? -50.462 -6.631  25.832  1    47.17  ? 186 LEU D CD1 1 
ATOM   7087 C  CD2 . LEU D 2 16  ? -48.074 -5.949  25.711  1    43.37  ? 186 LEU D CD2 1 
ATOM   7088 N  N   . ARG D 2 17  ? -48.537 -8.364  20.92   1    53.18  ? 187 ARG D N   1 
ATOM   7089 C  CA  . ARG D 2 17  ? -48.315 -9.489  20.017  1    55.1   ? 187 ARG D CA  1 
ATOM   7090 C  C   . ARG D 2 17  ? -46.927 -9.384  19.385  1    52.37  ? 187 ARG D C   1 
ATOM   7091 O  O   . ARG D 2 17  ? -46.208 -10.363 19.227  1    56.1   ? 187 ARG D O   1 
ATOM   7092 C  CB  . ARG D 2 17  ? -49.433 -9.556  18.972  1    51.27  ? 187 ARG D CB  1 
ATOM   7093 C  CG  . ARG D 2 17  ? -50.715 -10.145 19.545  1    52.34  ? 187 ARG D CG  1 
ATOM   7094 C  CD  . ARG D 2 17  ? -50.527 -11.627 19.819  1    49.65  ? 187 ARG D CD  1 
ATOM   7095 N  NE  . ARG D 2 17  ? -50.473 -12.335 18.537  1    51.86  ? 187 ARG D NE  1 
ATOM   7096 C  CZ  . ARG D 2 17  ? -51.534 -12.76  17.831  1    51.31  ? 187 ARG D CZ  1 
ATOM   7097 N  NH1 . ARG D 2 17  ? -52.759 -12.68  18.341  1    49.1   ? 187 ARG D NH1 1 
ATOM   7098 N  NH2 . ARG D 2 17  ? -51.356 -13.329 16.648  1    48.3   ? 187 ARG D NH2 1 
ATOM   7099 N  N   . GLU D 2 18  ? -46.559 -8.161  19.033  1    50.58  ? 188 GLU D N   1 
ATOM   7100 C  CA  . GLU D 2 18  ? -45.297 -7.885  18.378  1    56.06  ? 188 GLU D CA  1 
ATOM   7101 C  C   . GLU D 2 18  ? -44.161 -8.134  19.372  1    55.29  ? 188 GLU D C   1 
ATOM   7102 O  O   . GLU D 2 18  ? -43.214 -8.835  19.059  1    54.33  ? 188 GLU D O   1 
ATOM   7103 C  CB  . GLU D 2 18  ? -45.438 -6.428  17.95   1    61.28  ? 188 GLU D CB  1 
ATOM   7104 C  CG  . GLU D 2 18  ? -44.757 -6.039  16.643  1    71.84  ? 188 GLU D CG  1 
ATOM   7105 C  CD  . GLU D 2 18  ? -44.925 -4.527  16.465  1    73.74  ? 188 GLU D CD  1 
ATOM   7106 O  OE1 . GLU D 2 18  ? -46.058 -4.075  16.138  1    69     ? 188 GLU D OE1 1 
ATOM   7107 O  OE2 . GLU D 2 18  ? -43.921 -3.795  16.711  1    66.64  ? 188 GLU D OE2 1 
ATOM   7108 N  N   . MET D 2 19  ? -44.3   -7.611  20.593  1    50.4   ? 189 MET D N   1 
ATOM   7109 C  CA  . MET D 2 19  ? -43.256 -7.645  21.599  1    51.19  ? 189 MET D CA  1 
ATOM   7110 C  C   . MET D 2 19  ? -43.026 -9.052  22.152  1    51.4   ? 189 MET D C   1 
ATOM   7111 O  O   . MET D 2 19  ? -41.893 -9.395  22.489  1    54.22  ? 189 MET D O   1 
ATOM   7112 C  CB  . MET D 2 19  ? -43.591 -6.687  22.748  1    47.31  ? 189 MET D CB  1 
ATOM   7113 C  CG  . MET D 2 19  ? -43.553 -5.232  22.353  1    51.14  ? 189 MET D CG  1 
ATOM   7114 S  SD  . MET D 2 19  ? -41.953 -4.732  21.683  1    55.59  ? 189 MET D SD  1 
ATOM   7115 C  CE  . MET D 2 19  ? -40.898 -5.216  23.081  1    58.89  ? 189 MET D CE  1 
ATOM   7116 N  N   . GLU D 2 20  ? -44.094 -9.849  22.293  1    49.66  ? 190 GLU D N   1 
ATOM   7117 C  CA  . GLU D 2 20  ? -43.959 -11.216 22.779  1    50.59  ? 190 GLU D CA  1 
ATOM   7118 C  C   . GLU D 2 20  ? -43.097 -12.058 21.826  1    52.31  ? 190 GLU D C   1 
ATOM   7119 O  O   . GLU D 2 20  ? -42.381 -12.954 22.268  1    58.01  ? 190 GLU D O   1 
ATOM   7120 C  CB  . GLU D 2 20  ? -45.316 -11.881 22.999  1    48.08  ? 190 GLU D CB  1 
ATOM   7121 C  CG  . GLU D 2 20  ? -46.058 -12.186 21.702  1    44.63  ? 190 GLU D CG  1 
ATOM   7122 C  CD  . GLU D 2 20  ? -47.252 -13.106 21.917  1    46.78  ? 190 GLU D CD  1 
ATOM   7123 O  OE1 . GLU D 2 20  ? -47.5   -13.543 23.068  1    43.16  ? 190 GLU D OE1 1 
ATOM   7124 O  OE2 . GLU D 2 20  ? -47.946 -13.375 20.913  1    48.87  ? 190 GLU D OE2 1 
ATOM   7125 N  N   . VAL D 2 21  ? -43.173 -11.773 20.522  1    47.7   ? 191 VAL D N   1 
ATOM   7126 C  CA  . VAL D 2 21  ? -42.281 -12.368 19.545  1    50.7   ? 191 VAL D CA  1 
ATOM   7127 C  C   . VAL D 2 21  ? -40.838 -12.009 19.886  1    55.05  ? 191 VAL D C   1 
ATOM   7128 O  O   . VAL D 2 21  ? -39.99  -12.895 19.911  1    66.25  ? 191 VAL D O   1 
ATOM   7129 C  CB  . VAL D 2 21  ? -42.618 -11.985 18.085  1    51.64  ? 191 VAL D CB  1 
ATOM   7130 C  CG1 . VAL D 2 21  ? -41.467 -12.302 17.139  1    48.14  ? 191 VAL D CG1 1 
ATOM   7131 C  CG2 . VAL D 2 21  ? -43.912 -12.624 17.588  1    46.79  ? 191 VAL D CG2 1 
ATOM   7132 N  N   . LYS D 2 22  ? -40.571 -10.73  20.168  1    52.65  ? 192 LYS D N   1 
ATOM   7133 C  CA  . LYS D 2 22  ? -39.216 -10.25  20.359  1    60.02  ? 192 LYS D CA  1 
ATOM   7134 C  C   . LYS D 2 22  ? -38.654 -10.632 21.726  1    55.04  ? 192 LYS D C   1 
ATOM   7135 O  O   . LYS D 2 22  ? -37.449 -10.76  21.877  1    58.44  ? 192 LYS D O   1 
ATOM   7136 C  CB  . LYS D 2 22  ? -39.099 -8.782  19.94   1    80.73  ? 192 LYS D CB  1 
ATOM   7137 C  CG  . LYS D 2 22  ? -38.835 -8.616  18.399  1    88.69  ? 192 LYS D CG  1 
ATOM   7138 C  CD  . LYS D 2 22  ? -37.856 -7.47   18.152  1    99.71  ? 192 LYS D CD  1 
ATOM   7139 C  CE  . LYS D 2 22  ? -36.69  -7.625  17.197  1    93.59  ? 192 LYS D CE  1 
ATOM   7140 N  NZ  . LYS D 2 22  ? -37.032 -7.274  15.816  1    104.54 ? 192 LYS D NZ  1 
ATOM   7141 N  N   . CYS D 2 23  ? -39.522 -10.869 22.706  1    53.89  ? 193 CYS D N   1 
ATOM   7142 C  CA  . CYS D 2 23  ? -39.078 -11.272 24.04   1    53.7   ? 193 CYS D CA  1 
ATOM   7143 C  C   . CYS D 2 23  ? -39.052 -12.792 24.201  1    52.81  ? 193 CYS D C   1 
ATOM   7144 O  O   . CYS D 2 23  ? -38.941 -13.282 25.319  1    52.39  ? 193 CYS D O   1 
ATOM   7145 C  CB  . CYS D 2 23  ? -39.991 -10.744 25.147  1    52.45  ? 193 CYS D CB  1 
ATOM   7146 S  SG  . CYS D 2 23  ? -39.809 -8.967  25.452  1    59.4   ? 193 CYS D SG  1 
ATOM   7147 N  N   . LYS D 2 24  ? -39.166 -13.532 23.092  1    52     ? 194 LYS D N   1 
ATOM   7148 C  CA  . LYS D 2 24  ? -39.389 -14.964 23.187  1    53.83  ? 194 LYS D CA  1 
ATOM   7149 C  C   . LYS D 2 24  ? -38.047 -15.647 23.451  1    50.67  ? 194 LYS D C   1 
ATOM   7150 O  O   . LYS D 2 24  ? -37.073 -15.358 22.767  1    50.05  ? 194 LYS D O   1 
ATOM   7151 C  CB  . LYS D 2 24  ? -40.048 -15.496 21.905  1    59.02  ? 194 LYS D CB  1 
ATOM   7152 C  CG  . LYS D 2 24  ? -40.615 -16.898 22.01   1    64.51  ? 194 LYS D CG  1 
ATOM   7153 C  CD  . LYS D 2 24  ? -40.891 -17.585 20.678  1    73.13  ? 194 LYS D CD  1 
ATOM   7154 C  CE  . LYS D 2 24  ? -41.317 -19.027 20.903  1    87.6   ? 194 LYS D CE  1 
ATOM   7155 N  NZ  . LYS D 2 24  ? -42.044 -19.576 19.754  1    86.98  ? 194 LYS D NZ  1 
ATOM   7156 N  N   . PRO D 2 25  ? -37.967 -16.601 24.41   1    49.94  ? 195 PRO D N   1 
ATOM   7157 C  CA  . PRO D 2 25  ? -36.743 -17.351 24.614  1    50.21  ? 195 PRO D CA  1 
ATOM   7158 C  C   . PRO D 2 25  ? -36.478 -18.334 23.495  1    52.21  ? 195 PRO D C   1 
ATOM   7159 O  O   . PRO D 2 25  ? -37.374 -18.596 22.684  1    58.17  ? 195 PRO D O   1 
ATOM   7160 C  CB  . PRO D 2 25  ? -37.046 -18.06  25.931  1    46.18  ? 195 PRO D CB  1 
ATOM   7161 C  CG  . PRO D 2 25  ? -38.087 -17.202 26.582  1    48.81  ? 195 PRO D CG  1 
ATOM   7162 C  CD  . PRO D 2 25  ? -38.987 -16.996 25.401  1    49.55  ? 195 PRO D CD  1 
ATOM   7163 N  N   . LYS D 2 26  ? -35.265 -18.872 23.451  1    54.49  ? 196 LYS D N   1 
ATOM   7164 C  CA  . LYS D 2 26  ? -34.926 -19.905 22.445  1    61.75  ? 196 LYS D CA  1 
ATOM   7165 C  C   . LYS D 2 26  ? -35.632 -21.205 22.83   1    61.49  ? 196 LYS D C   1 
ATOM   7166 O  O   . LYS D 2 26  ? -35.41  -21.673 23.953  1    67.58  ? 196 LYS D O   1 
ATOM   7167 C  CB  . LYS D 2 26  ? -33.412 -20.086 22.384  1    73.23  ? 196 LYS D CB  1 
ATOM   7168 C  CG  . LYS D 2 26  ? -32.65  -18.891 21.844  1    88.61  ? 196 LYS D CG  1 
ATOM   7169 C  CD  . LYS D 2 26  ? -31.143 -19.107 21.823  1    109.66 ? 196 LYS D CD  1 
ATOM   7170 C  CE  . LYS D 2 26  ? -30.408 -17.931 21.266  1    121.45 ? 196 LYS D CE  1 
ATOM   7171 N  NZ  . LYS D 2 26  ? -28.959 -18.142 21.274  1    125.03 ? 196 LYS D NZ  1 
ATOM   7172 N  N   . VAL D 2 27  ? -36.419 -21.775 21.919  1    63.69  ? 197 VAL D N   1 
ATOM   7173 C  CA  . VAL D 2 27  ? -37.228 -22.99  22.232  1    63.23  ? 197 VAL D CA  1 
ATOM   7174 C  C   . VAL D 2 27  ? -36.323 -24.148 22.67   1    59.96  ? 197 VAL D C   1 
ATOM   7175 O  O   . VAL D 2 27  ? -36.706 -24.861 23.613  1    69.07  ? 197 VAL D O   1 
ATOM   7176 C  CB  . VAL D 2 27  ? -38.104 -23.369 21.025  1    65.96  ? 197 VAL D CB  1 
ATOM   7177 C  CG1 . VAL D 2 27  ? -38.931 -24.619 21.291  1    60.44  ? 197 VAL D CG1 1 
ATOM   7178 C  CG2 . VAL D 2 27  ? -39.003 -22.213 20.607  1    66.61  ? 197 VAL D CG2 1 
ATOM   7179 N  N   . GLY D 2 28  ? -35.177 -24.332 22.028  1    53.43  ? 198 GLY D N   1 
ATOM   7180 C  CA  . GLY D 2 28  ? -34.343 -25.493 22.377  1    61.27  ? 198 GLY D CA  1 
ATOM   7181 C  C   . GLY D 2 28  ? -33.104 -25.085 23.128  1    67.17  ? 198 GLY D C   1 
ATOM   7182 O  O   . GLY D 2 28  ? -32.02  -25.591 22.789  1    71.66  ? 198 GLY D O   1 
ATOM   7183 N  N   . TYR D 2 29  ? -33.251 -24.224 24.131  1    64.28  ? 199 TYR D N   1 
ATOM   7184 C  CA  . TYR D 2 29  ? -32.067 -23.703 24.813  1    60.61  ? 199 TYR D CA  1 
ATOM   7185 C  C   . TYR D 2 29  ? -31.542 -24.729 25.819  1    57.84  ? 199 TYR D C   1 
ATOM   7186 O  O   . TYR D 2 29  ? -30.345 -24.766 26.082  1    53.79  ? 199 TYR D O   1 
ATOM   7187 C  CB  . TYR D 2 29  ? -32.239 -22.315 25.457  1    53.44  ? 199 TYR D CB  1 
ATOM   7188 C  CG  . TYR D 2 29  ? -32.936 -22.282 26.814  1    49.99  ? 199 TYR D CG  1 
ATOM   7189 C  CD1 . TYR D 2 29  ? -32.303 -22.762 27.96   1    51.54  ? 199 TYR D CD1 1 
ATOM   7190 C  CD2 . TYR D 2 29  ? -34.212 -21.756 26.963  1    48.59  ? 199 TYR D CD2 1 
ATOM   7191 C  CE1 . TYR D 2 29  ? -32.916 -22.733 29.207  1    53.18  ? 199 TYR D CE1 1 
ATOM   7192 C  CE2 . TYR D 2 29  ? -34.846 -21.745 28.2    1    50.78  ? 199 TYR D CE2 1 
ATOM   7193 C  CZ  . TYR D 2 29  ? -34.201 -22.227 29.328  1    51.04  ? 199 TYR D CZ  1 
ATOM   7194 O  OH  . TYR D 2 29  ? -34.859 -22.208 30.52   1    48.41  ? 199 TYR D OH  1 
ATOM   7195 N  N   . MET D 2 30  ? -32.4   -25.568 26.391  1    56.55  ? 200 MET D N   1 
ATOM   7196 C  CA  . MET D 2 30  ? -31.919 -26.461 27.483  1    59     ? 200 MET D CA  1 
ATOM   7197 C  C   . MET D 2 30  ? -30.885 -27.471 26.969  1    63.67  ? 200 MET D C   1 
ATOM   7198 O  O   . MET D 2 30  ? -29.99  -27.855 27.74   1    58.36  ? 200 MET D O   1 
ATOM   7199 C  CB  . MET D 2 30  ? -33.081 -27.205 28.144  1    60.16  ? 200 MET D CB  1 
ATOM   7200 C  CG  . MET D 2 30  ? -32.781 -27.672 29.546  1    63.61  ? 200 MET D CG  1 
ATOM   7201 S  SD  . MET D 2 30  ? -32.314 -26.298 30.612  1    63.43  ? 200 MET D SD  1 
ATOM   7202 C  CE  . MET D 2 30  ? -33.966 -25.734 31.034  1    62.56  ? 200 MET D CE  1 
ATOM   7203 N  N   . LYS D 2 31  ? -31.005 -27.877 25.711  1    66.78  ? 201 LYS D N   1 
ATOM   7204 C  CA  . LYS D 2 31  ? -30.097 -28.907 25.158  1    67.15  ? 201 LYS D CA  1 
ATOM   7205 C  C   . LYS D 2 31  ? -28.717 -28.288 24.931  1    61.89  ? 201 LYS D C   1 
ATOM   7206 O  O   . LYS D 2 31  ? -27.733 -29.04  24.866  1    66.64  ? 201 LYS D O   1 
ATOM   7207 C  CB  . LYS D 2 31  ? -30.758 -29.458 23.892  1    77.31  ? 201 LYS D CB  1 
ATOM   7208 C  CG  . LYS D 2 31  ? -30.973 -28.44  22.789  1    84.41  ? 201 LYS D CG  1 
ATOM   7209 C  CD  . LYS D 2 31  ? -31.632 -29.05  21.56   1    93.66  ? 201 LYS D CD  1 
ATOM   7210 C  CE  . LYS D 2 31  ? -33.043 -29.457 21.826  1    94.63  ? 201 LYS D CE  1 
ATOM   7211 N  NZ  . LYS D 2 31  ? -33.668 -30.042 20.637  1    90.75  ? 201 LYS D NZ  1 
ATOM   7212 N  N   . LYS D 2 32  ? -28.657 -26.965 24.83   1    57.92  ? 202 LYS D N   1 
ATOM   7213 C  CA  . LYS D 2 32  ? -27.364 -26.269 24.639  1    61.22  ? 202 LYS D CA  1 
ATOM   7214 C  C   . LYS D 2 32  ? -26.811 -25.867 26.009  1    56.23  ? 202 LYS D C   1 
ATOM   7215 O  O   . LYS D 2 32  ? -25.689 -25.349 26.042  1    55.71  ? 202 LYS D O   1 
ATOM   7216 C  CB  . LYS D 2 32  ? -27.609 -25.106 23.679  1    72.68  ? 202 LYS D CB  1 
ATOM   7217 C  CG  . LYS D 2 32  ? -28.308 -25.492 22.391  1    81.69  ? 202 LYS D CG  1 
ATOM   7218 C  CD  . LYS D 2 32  ? -28.474 -24.295 21.467  1    94.89  ? 202 LYS D CD  1 
ATOM   7219 C  CE  . LYS D 2 32  ? -28.941 -24.698 20.11   1    112.54 ? 202 LYS D CE  1 
ATOM   7220 N  NZ  . LYS D 2 32  ? -29.267 -23.522 19.299  1    111.69 ? 202 LYS D NZ  1 
ATOM   7221 N  N   . GLN D 2 33  ? -27.581 -26.081 27.076  1    55.9   ? 203 GLN D N   1 
ATOM   7222 C  CA  . GLN D 2 33  ? -27.088 -25.836 28.456  1    53.11  ? 203 GLN D CA  1 
ATOM   7223 C  C   . GLN D 2 33  ? -26.466 -27.144 28.954  1    58.29  ? 203 GLN D C   1 
ATOM   7224 O  O   . GLN D 2 33  ? -27.219 -28.066 29.309  1    56.36  ? 203 GLN D O   1 
ATOM   7225 C  CB  . GLN D 2 33  ? -28.201 -25.372 29.394  1    46.23  ? 203 GLN D CB  1 
ATOM   7226 C  CG  . GLN D 2 33  ? -28.646 -23.93  29.188  1    46.41  ? 203 GLN D CG  1 
ATOM   7227 C  CD  . GLN D 2 33  ? -27.765 -22.928 29.897  1    46.98  ? 203 GLN D CD  1 
ATOM   7228 O  OE1 . GLN D 2 33  ? -26.794 -23.282 30.571  1    48.75  ? 203 GLN D OE1 1 
ATOM   7229 N  NE2 . GLN D 2 33  ? -28.093 -21.657 29.739  1    40.89  ? 203 GLN D NE2 1 
ATOM   7230 N  N   . PRO D 2 34  ? -25.128 -27.266 28.989  1    60.64  ? 204 PRO D N   1 
ATOM   7231 C  CA  . PRO D 2 34  ? -24.479 -28.526 29.346  1    58.37  ? 204 PRO D CA  1 
ATOM   7232 C  C   . PRO D 2 34  ? -24.793 -29.025 30.757  1    56.99  ? 204 PRO D C   1 
ATOM   7233 O  O   . PRO D 2 34  ? -24.852 -30.22  30.984  1    64.63  ? 204 PRO D O   1 
ATOM   7234 C  CB  . PRO D 2 34  ? -22.983 -28.268 29.119  1    58.08  ? 204 PRO D CB  1 
ATOM   7235 C  CG  . PRO D 2 34  ? -22.849 -26.76  29.213  1    66.58  ? 204 PRO D CG  1 
ATOM   7236 C  CD  . PRO D 2 34  ? -24.161 -26.196 28.685  1    64.11  ? 204 PRO D CD  1 
ATOM   7237 N  N   . ASP D 2 35  ? -25.045 -28.127 31.705  1    56.25  ? 205 ASP D N   1 
ATOM   7238 C  CA  . ASP D 2 35  ? -25.079 -28.558 33.086  1    56.89  ? 205 ASP D CA  1 
ATOM   7239 C  C   . ASP D 2 35  ? -26.475 -28.443 33.718  1    57.14  ? 205 ASP D C   1 
ATOM   7240 O  O   . ASP D 2 35  ? -26.634 -28.788 34.886  1    61.31  ? 205 ASP D O   1 
ATOM   7241 C  CB  . ASP D 2 35  ? -23.947 -27.914 33.871  1    59.23  ? 205 ASP D CB  1 
ATOM   7242 C  CG  . ASP D 2 35  ? -23.748 -28.529 35.246  1    73.53  ? 205 ASP D CG  1 
ATOM   7243 O  OD1 . ASP D 2 35  ? -23.904 -29.784 35.333  1    77.19  ? 205 ASP D OD1 1 
ATOM   7244 O  OD2 . ASP D 2 35  ? -23.467 -27.761 36.214  1    76.45  ? 205 ASP D OD2 1 
ATOM   7245 N  N   . ILE D 2 36  ? -27.486 -27.964 32.985  1    50.51  ? 206 ILE D N   1 
ATOM   7246 C  CA  . ILE D 2 36  ? -28.801 -27.806 33.595  1    52.05  ? 206 ILE D CA  1 
ATOM   7247 C  C   . ILE D 2 36  ? -29.893 -28.377 32.681  1    51.03  ? 206 ILE D C   1 
ATOM   7248 O  O   . ILE D 2 36  ? -29.674 -28.537 31.48   1    54.3   ? 206 ILE D O   1 
ATOM   7249 C  CB  . ILE D 2 36  ? -29.052 -26.353 34.078  1    55.71  ? 206 ILE D CB  1 
ATOM   7250 C  CG1 . ILE D 2 36  ? -29.094 -25.337 32.964  1    50.86  ? 206 ILE D CG1 1 
ATOM   7251 C  CG2 . ILE D 2 36  ? -28.057 -25.902 35.154  1    55.71  ? 206 ILE D CG2 1 
ATOM   7252 C  CD1 . ILE D 2 36  ? -29.254 -23.93  33.481  1    49.86  ? 206 ILE D CD1 1 
ATOM   7253 N  N   . THR D 2 37  ? -31.06  -28.71  33.264  1    51.6   ? 207 THR D N   1 
ATOM   7254 C  CA  . THR D 2 37  ? -32.099 -29.526 32.634  1    55.18  ? 207 THR D CA  1 
ATOM   7255 C  C   . THR D 2 37  ? -33.473 -28.904 32.826  1    55.74  ? 207 THR D C   1 
ATOM   7256 O  O   . THR D 2 37  ? -33.636 -27.962 33.599  1    53.62  ? 207 THR D O   1 
ATOM   7257 C  CB  . THR D 2 37  ? -32.179 -30.947 33.209  1    56.55  ? 207 THR D CB  1 
ATOM   7258 O  OG1 . THR D 2 37  ? -32.483 -30.821 34.596  1    54.69  ? 207 THR D OG1 1 
ATOM   7259 C  CG2 . THR D 2 37  ? -30.921 -31.766 32.989  1    52.86  ? 207 THR D CG2 1 
ATOM   7260 N  N   . ASN D 2 38  ? -34.471 -29.508 32.161  1    59.45  ? 208 ASN D N   1 
ATOM   7261 C  CA  . ASN D 2 38  ? -35.839 -29.036 32.243  1    59.94  ? 208 ASN D CA  1 
ATOM   7262 C  C   . ASN D 2 38  ? -36.326 -29.189 33.677  1    61.16  ? 208 ASN D C   1 
ATOM   7263 O  O   . ASN D 2 38  ? -37.067 -28.336 34.164  1    61.35  ? 208 ASN D O   1 
ATOM   7264 C  CB  . ASN D 2 38  ? -36.744 -29.702 31.211  1    62.28  ? 208 ASN D CB  1 
ATOM   7265 C  CG  . ASN D 2 38  ? -36.519 -29.219 29.797  1    64.04  ? 208 ASN D CG  1 
ATOM   7266 O  OD1 . ASN D 2 38  ? -36.229 -28.035 29.565  1    61.82  ? 208 ASN D OD1 1 
ATOM   7267 N  ND2 . ASN D 2 38  ? -36.68  -30.132 28.846  1    60.35  ? 208 ASN D ND2 1 
ATOM   7268 N  N   . SER D 2 39  ? -35.857 -30.267 34.33   1    66.32  ? 209 SER D N   1 
ATOM   7269 C  CA  . SER D 2 39  ? -36.248 -30.69  35.672  1    62.92  ? 209 SER D CA  1 
ATOM   7270 C  C   . SER D 2 39  ? -35.714 -29.722 36.731  1    59.17  ? 209 SER D C   1 
ATOM   7271 O  O   . SER D 2 39  ? -36.395 -29.429 37.709  1    59.88  ? 209 SER D O   1 
ATOM   7272 C  CB  . SER D 2 39  ? -35.767 -32.1   35.941  1    64.32  ? 209 SER D CB  1 
ATOM   7273 O  OG  . SER D 2 39  ? -35.818 -32.394 37.329  1    64.94  ? 209 SER D OG  1 
ATOM   7274 N  N   . MET D 2 40  ? -34.481 -29.254 36.548  1    52.84  ? 210 MET D N   1 
ATOM   7275 C  CA  . MET D 2 40  ? -33.909 -28.273 37.456  1    52.6   ? 210 MET D CA  1 
ATOM   7276 C  C   . MET D 2 40  ? -34.683 -26.966 37.347  1    50.56  ? 210 MET D C   1 
ATOM   7277 O  O   . MET D 2 40  ? -34.994 -26.349 38.359  1    47.61  ? 210 MET D O   1 
ATOM   7278 C  CB  . MET D 2 40  ? -32.434 -28.013 37.132  1    49.01  ? 210 MET D CB  1 
ATOM   7279 C  CG  . MET D 2 40  ? -31.575 -29.197 37.426  1    51.96  ? 210 MET D CG  1 
ATOM   7280 S  SD  . MET D 2 40  ? -29.905 -28.881 36.863  1    52.98  ? 210 MET D SD  1 
ATOM   7281 C  CE  . MET D 2 40  ? -29.24  -30.548 36.794  1    48.01  ? 210 MET D CE  1 
ATOM   7282 N  N   . ARG D 2 41  ? -35.018 -26.588 36.11   1    48.82  ? 211 ARG D N   1 
ATOM   7283 C  CA  . ARG D 2 41  ? -35.671 -25.314 35.858  1    48.07  ? 211 ARG D CA  1 
ATOM   7284 C  C   . ARG D 2 41  ? -37.037 -25.343 36.53   1    46.05  ? 211 ARG D C   1 
ATOM   7285 O  O   . ARG D 2 41  ? -37.428 -24.35  37.147  1    44.75  ? 211 ARG D O   1 
ATOM   7286 C  CB  . ARG D 2 41  ? -35.781 -25.066 34.347  1    46.86  ? 211 ARG D CB  1 
ATOM   7287 C  CG  . ARG D 2 41  ? -36.604 -23.84  33.976  1    45.02  ? 211 ARG D CG  1 
ATOM   7288 C  CD  . ARG D 2 41  ? -36.908 -23.844 32.49   1    46.69  ? 211 ARG D CD  1 
ATOM   7289 N  NE  . ARG D 2 41  ? -37.805 -22.765 32.081  1    45.91  ? 211 ARG D NE  1 
ATOM   7290 C  CZ  . ARG D 2 41  ? -39.084 -22.716 32.426  1    46.89  ? 211 ARG D CZ  1 
ATOM   7291 N  NH1 . ARG D 2 41  ? -39.614 -23.727 33.108  1    44.83  ? 211 ARG D NH1 1 
ATOM   7292 N  NH2 . ARG D 2 41  ? -39.82  -21.673 32.065  1    41.31  ? 211 ARG D NH2 1 
ATOM   7293 N  N   . ALA D 2 42  ? -37.716 -26.499 36.404  1    44.96  ? 212 ALA D N   1 
ATOM   7294 C  CA  . ALA D 2 42  ? -39.001 -26.757 37.025  1    46.94  ? 212 ALA D CA  1 
ATOM   7295 C  C   . ALA D 2 42  ? -38.918 -26.579 38.553  1    52.01  ? 212 ALA D C   1 
ATOM   7296 O  O   . ALA D 2 42  ? -39.822 -25.981 39.153  1    54.13  ? 212 ALA D O   1 
ATOM   7297 C  CB  . ALA D 2 42  ? -39.504 -28.116 36.619  1    42.14  ? 212 ALA D CB  1 
ATOM   7298 N  N   . ILE D 2 43  ? -37.849 -27.095 39.186  1    46.75  ? 213 ILE D N   1 
ATOM   7299 C  CA  . ILE D 2 43  ? -37.663 -26.918 40.619  1    45.42  ? 213 ILE D CA  1 
ATOM   7300 C  C   . ILE D 2 43  ? -37.494 -25.429 40.941  1    47.62  ? 213 ILE D C   1 
ATOM   7301 O  O   . ILE D 2 43  ? -38.03  -24.923 41.927  1    49.26  ? 213 ILE D O   1 
ATOM   7302 C  CB  . ILE D 2 43  ? -36.474 -27.759 41.102  1    44.42  ? 213 ILE D CB  1 
ATOM   7303 C  CG1 . ILE D 2 43  ? -36.754 -29.271 40.964  1    44.16  ? 213 ILE D CG1 1 
ATOM   7304 C  CG2 . ILE D 2 43  ? -36.078 -27.376 42.523  1    41.95  ? 213 ILE D CG2 1 
ATOM   7305 C  CD1 . ILE D 2 43  ? -35.508 -30.118 41.145  1    43.63  ? 213 ILE D CD1 1 
ATOM   7306 N  N   . LEU D 2 44  ? -36.777 -24.718 40.071  1    44.78  ? 214 LEU D N   1 
ATOM   7307 C  CA  . LEU D 2 44  ? -36.525 -23.309 40.263  1    45.06  ? 214 LEU D CA  1 
ATOM   7308 C  C   . LEU D 2 44  ? -37.846 -22.546 40.202  1    46.99  ? 214 LEU D C   1 
ATOM   7309 O  O   . LEU D 2 44  ? -38.16  -21.803 41.143  1    47.59  ? 214 LEU D O   1 
ATOM   7310 C  CB  . LEU D 2 44  ? -35.518 -22.831 39.217  1    44.36  ? 214 LEU D CB  1 
ATOM   7311 C  CG  . LEU D 2 44  ? -35.257 -21.323 39.171  1    43.01  ? 214 LEU D CG  1 
ATOM   7312 C  CD1 . LEU D 2 44  ? -34.654 -20.901 40.49   1    37.89  ? 214 LEU D CD1 1 
ATOM   7313 C  CD2 . LEU D 2 44  ? -34.362 -20.95  37.991  1    40.16  ? 214 LEU D CD2 1 
ATOM   7314 N  N   . VAL D 2 45  ? -38.61  -22.731 39.107  1    43.53  ? 215 VAL D N   1 
ATOM   7315 C  CA  . VAL D 2 45  ? -39.854 -21.992 38.92   1    42.06  ? 215 VAL D CA  1 
ATOM   7316 C  C   . VAL D 2 45  ? -40.798 -22.298 40.088  1    47.9   ? 215 VAL D C   1 
ATOM   7317 O  O   . VAL D 2 45  ? -41.443 -21.391 40.612  1    47.08  ? 215 VAL D O   1 
ATOM   7318 C  CB  . VAL D 2 45  ? -40.514 -22.26  37.559  1    40.34  ? 215 VAL D CB  1 
ATOM   7319 C  CG1 . VAL D 2 45  ? -41.84  -21.509 37.39   1    38.6   ? 215 VAL D CG1 1 
ATOM   7320 C  CG2 . VAL D 2 45  ? -39.571 -21.957 36.397  1    38.98  ? 215 VAL D CG2 1 
ATOM   7321 N  N   . ASP D 2 46  ? -40.849 -23.578 40.512  1    50.37  ? 216 ASP D N   1 
ATOM   7322 C  CA  . ASP D 2 46  ? -41.76  -23.995 41.563  1    49.87  ? 216 ASP D CA  1 
ATOM   7323 C  C   . ASP D 2 46  ? -41.409 -23.26  42.847  1    50.62  ? 216 ASP D C   1 
ATOM   7324 O  O   . ASP D 2 46  ? -42.302 -22.832 43.57   1    54.43  ? 216 ASP D O   1 
ATOM   7325 C  CB  . ASP D 2 46  ? -41.695 -25.478 41.852  1    51.63  ? 216 ASP D CB  1 
ATOM   7326 C  CG  . ASP D 2 46  ? -42.743 -25.958 42.85   1    56.06  ? 216 ASP D CG  1 
ATOM   7327 O  OD1 . ASP D 2 46  ? -43.891 -26.183 42.423  1    54.71  ? 216 ASP D OD1 1 
ATOM   7328 O  OD2 . ASP D 2 46  ? -42.425 -26.055 44.055  1    57.73  ? 216 ASP D OD2 1 
ATOM   7329 N  N   . TRP D 2 47  ? -40.104 -23.127 43.109  1    49.65  ? 217 TRP D N   1 
ATOM   7330 C  CA  . TRP D 2 47  ? -39.597 -22.335 44.221  1    50.99  ? 217 TRP D CA  1 
ATOM   7331 C  C   . TRP D 2 47  ? -40.04  -20.863 44.12   1    51.27  ? 217 TRP D C   1 
ATOM   7332 O  O   . TRP D 2 47  ? -40.465 -20.28  45.111  1    52.33  ? 217 TRP D O   1 
ATOM   7333 C  CB  . TRP D 2 47  ? -38.07  -22.478 44.304  1    45.22  ? 217 TRP D CB  1 
ATOM   7334 C  CG  . TRP D 2 47  ? -37.435 -21.57  45.322  1    49.02  ? 217 TRP D CG  1 
ATOM   7335 C  CD1 . TRP D 2 47  ? -37.55  -21.691 46.674  1    48.11  ? 217 TRP D CD1 1 
ATOM   7336 C  CD2 . TRP D 2 47  ? -36.566 -20.43  45.092  1    49.36  ? 217 TRP D CD2 1 
ATOM   7337 N  NE1 . TRP D 2 47  ? -36.829 -20.711 47.299  1    49.09  ? 217 TRP D NE1 1 
ATOM   7338 C  CE2 . TRP D 2 47  ? -36.199 -19.933 46.363  1    47.66  ? 217 TRP D CE2 1 
ATOM   7339 C  CE3 . TRP D 2 47  ? -36.046 -19.798 43.954  1    47.15  ? 217 TRP D CE3 1 
ATOM   7340 C  CZ2 . TRP D 2 47  ? -35.356 -18.835 46.528  1    45.4   ? 217 TRP D CZ2 1 
ATOM   7341 C  CZ3 . TRP D 2 47  ? -35.219 -18.705 44.119  1    48.64  ? 217 TRP D CZ3 1 
ATOM   7342 C  CH2 . TRP D 2 47  ? -34.872 -18.236 45.387  1    46.17  ? 217 TRP D CH2 1 
ATOM   7343 N  N   . LEU D 2 48  ? -39.939 -20.26  42.924  1    46.63  ? 218 LEU D N   1 
ATOM   7344 C  CA  . LEU D 2 48  ? -40.331 -18.878 42.718  1    44.26  ? 218 LEU D CA  1 
ATOM   7345 C  C   . LEU D 2 48  ? -41.822 -18.662 43.015  1    48.91  ? 218 LEU D C   1 
ATOM   7346 O  O   . LEU D 2 48  ? -42.215 -17.586 43.469  1    44.79  ? 218 LEU D O   1 
ATOM   7347 C  CB  . LEU D 2 48  ? -39.954 -18.465 41.301  1    40.57  ? 218 LEU D CB  1 
ATOM   7348 C  CG  . LEU D 2 48  ? -38.449 -18.289 41.073  1    45.1   ? 218 LEU D CG  1 
ATOM   7349 C  CD1 . LEU D 2 48  ? -38.123 -17.869 39.652  1    45.16  ? 218 LEU D CD1 1 
ATOM   7350 C  CD2 . LEU D 2 48  ? -37.827 -17.309 42.058  1    41.98  ? 218 LEU D CD2 1 
ATOM   7351 N  N   . VAL D 2 49  ? -42.651 -19.688 42.777  1    48.87  ? 219 VAL D N   1 
ATOM   7352 C  CA  . VAL D 2 49  ? -44.064 -19.64  43.113  1    53.07  ? 219 VAL D CA  1 
ATOM   7353 C  C   . VAL D 2 49  ? -44.217 -19.501 44.633  1    57.87  ? 219 VAL D C   1 
ATOM   7354 O  O   . VAL D 2 49  ? -44.988 -18.653 45.087  1    58.92  ? 219 VAL D O   1 
ATOM   7355 C  CB  . VAL D 2 49  ? -44.843 -20.856 42.551  1    55.08  ? 219 VAL D CB  1 
ATOM   7356 C  CG1 . VAL D 2 49  ? -46.272 -20.944 43.087  1    49.52  ? 219 VAL D CG1 1 
ATOM   7357 C  CG2 . VAL D 2 49  ? -44.855 -20.885 41.027  1    51.96  ? 219 VAL D CG2 1 
ATOM   7358 N  N   . GLU D 2 50  ? -43.5   -20.343 45.402  1    55.25  ? 220 GLU D N   1 
ATOM   7359 C  CA  . GLU D 2 50  ? -43.505 -20.282 46.857  1    59.16  ? 220 GLU D CA  1 
ATOM   7360 C  C   . GLU D 2 50  ? -43.094 -18.887 47.313  1    55.75  ? 220 GLU D C   1 
ATOM   7361 O  O   . GLU D 2 50  ? -43.801 -18.251 48.087  1    54.28  ? 220 GLU D O   1 
ATOM   7362 C  CB  . GLU D 2 50  ? -42.51  -21.251 47.496  1    65.38  ? 220 GLU D CB  1 
ATOM   7363 C  CG  . GLU D 2 50  ? -42.952 -22.71  47.496  1    72.89  ? 220 GLU D CG  1 
ATOM   7364 C  CD  . GLU D 2 50  ? -41.996 -23.631 48.234  1    82.24  ? 220 GLU D CD  1 
ATOM   7365 O  OE1 . GLU D 2 50  ? -42.49  -24.524 48.964  1    95.63  ? 220 GLU D OE1 1 
ATOM   7366 O  OE2 . GLU D 2 50  ? -40.765 -23.455 48.097  1    77.8   ? 220 GLU D OE2 1 
ATOM   7367 N  N   . VAL D 2 51  ? -41.952 -18.425 46.794  1    53.36  ? 221 VAL D N   1 
ATOM   7368 C  CA  . VAL D 2 51  ? -41.441 -17.106 47.116  1    54.31  ? 221 VAL D CA  1 
ATOM   7369 C  C   . VAL D 2 51  ? -42.536 -16.067 46.889  1    51.78  ? 221 VAL D C   1 
ATOM   7370 O  O   . VAL D 2 51  ? -42.819 -15.263 47.784  1    46.95  ? 221 VAL D O   1 
ATOM   7371 C  CB  . VAL D 2 51  ? -40.143 -16.804 46.347  1    48.38  ? 221 VAL D CB  1 
ATOM   7372 C  CG1 . VAL D 2 51  ? -39.744 -15.338 46.458  1    41.06  ? 221 VAL D CG1 1 
ATOM   7373 C  CG2 . VAL D 2 51  ? -39.018 -17.688 46.865  1    44.01  ? 221 VAL D CG2 1 
ATOM   7374 N  N   . GLY D 2 52  ? -43.184 -16.162 45.718  1    47.24  ? 222 GLY D N   1 
ATOM   7375 C  CA  . GLY D 2 52  ? -44.242 -15.233 45.335  1    50.04  ? 222 GLY D CA  1 
ATOM   7376 C  C   . GLY D 2 52  ? -45.373 -15.191 46.368  1    55.17  ? 222 GLY D C   1 
ATOM   7377 O  O   . GLY D 2 52  ? -45.926 -14.121 46.636  1    54.7   ? 222 GLY D O   1 
ATOM   7378 N  N   . GLU D 2 53  ? -45.695 -16.368 46.918  1    58.14  ? 223 GLU D N   1 
ATOM   7379 C  CA  . GLU D 2 53  ? -46.715 -16.577 47.938  1    63.43  ? 223 GLU D CA  1 
ATOM   7380 C  C   . GLU D 2 53  ? -46.262 -16     49.281  1    58.98  ? 223 GLU D C   1 
ATOM   7381 O  O   . GLU D 2 53  ? -46.949 -15.176 49.851  1    59.47  ? 223 GLU D O   1 
ATOM   7382 C  CB  . GLU D 2 53  ? -46.951 -18.077 48.113  1    67.7   ? 223 GLU D CB  1 
ATOM   7383 C  CG  . GLU D 2 53  ? -48.385 -18.422 48.486  1    84.13  ? 223 GLU D CG  1 
ATOM   7384 C  CD  . GLU D 2 53  ? -49.406 -18.234 47.375  1    92.99  ? 223 GLU D CD  1 
ATOM   7385 O  OE1 . GLU D 2 53  ? -49.122 -17.509 46.356  1    74.23  ? 223 GLU D OE1 1 
ATOM   7386 O  OE2 . GLU D 2 53  ? -50.483 -18.892 47.555  1    100.57 ? 223 GLU D OE2 1 
ATOM   7387 N  N   . GLU D 2 54  ? -45.092 -16.421 49.766  1    57.89  ? 224 GLU D N   1 
ATOM   7388 C  CA  . GLU D 2 54  ? -44.507 -15.958 51.018  1    59.99  ? 224 GLU D CA  1 
ATOM   7389 C  C   . GLU D 2 54  ? -44.396 -14.427 51.112  1    58.88  ? 224 GLU D C   1 
ATOM   7390 O  O   . GLU D 2 54  ? -44.409 -13.903 52.217  1    59.05  ? 224 GLU D O   1 
ATOM   7391 C  CB  . GLU D 2 54  ? -43.134 -16.624 51.125  1    63.82  ? 224 GLU D CB  1 
ATOM   7392 C  CG  . GLU D 2 54  ? -42.208 -16.062 52.203  1    68.95  ? 224 GLU D CG  1 
ATOM   7393 C  CD  . GLU D 2 54  ? -42.399 -16.574 53.616  1    84.79  ? 224 GLU D CD  1 
ATOM   7394 O  OE1 . GLU D 2 54  ? -43.421 -17.248 53.925  1    94.56  ? 224 GLU D OE1 1 
ATOM   7395 O  OE2 . GLU D 2 54  ? -41.495 -16.263 54.422  1    90.5   ? 224 GLU D OE2 1 
ATOM   7396 N  N   . TYR D 2 55  ? -44.239 -13.717 49.982  1    53.29  ? 225 TYR D N   1 
ATOM   7397 C  CA  . TYR D 2 55  ? -43.977 -12.282 49.953  1    52.71  ? 225 TYR D CA  1 
ATOM   7398 C  C   . TYR D 2 55  ? -45.162 -11.515 49.362  1    57.85  ? 225 TYR D C   1 
ATOM   7399 O  O   . TYR D 2 55  ? -45.091 -10.295 49.209  1    56.19  ? 225 TYR D O   1 
ATOM   7400 C  CB  . TYR D 2 55  ? -42.646 -11.991 49.24   1    53.25  ? 225 TYR D CB  1 
ATOM   7401 C  CG  . TYR D 2 55  ? -41.444 -12.269 50.128  1    55.96  ? 225 TYR D CG  1 
ATOM   7402 C  CD1 . TYR D 2 55  ? -41.078 -11.388 51.149  1    56.23  ? 225 TYR D CD1 1 
ATOM   7403 C  CD2 . TYR D 2 55  ? -40.735 -13.456 50.016  1    55.88  ? 225 TYR D CD2 1 
ATOM   7404 C  CE1 . TYR D 2 55  ? -40.032 -11.677 52.017  1    58.86  ? 225 TYR D CE1 1 
ATOM   7405 C  CE2 . TYR D 2 55  ? -39.688 -13.749 50.877  1    58.39  ? 225 TYR D CE2 1 
ATOM   7406 C  CZ  . TYR D 2 55  ? -39.322 -12.857 51.873  1    58.19  ? 225 TYR D CZ  1 
ATOM   7407 O  OH  . TYR D 2 55  ? -38.255 -13.102 52.69   1    59.5   ? 225 TYR D OH  1 
ATOM   7408 N  N   . LYS D 2 56  ? -46.231 -12.264 49.033  1    65.14  ? 226 LYS D N   1 
ATOM   7409 C  CA  . LYS D 2 56  ? -47.529 -11.799 48.544  1    60     ? 226 LYS D CA  1 
ATOM   7410 C  C   . LYS D 2 56  ? -47.333 -10.956 47.289  1    53.86  ? 226 LYS D C   1 
ATOM   7411 O  O   . LYS D 2 56  ? -47.868 -9.85   47.177  1    50.52  ? 226 LYS D O   1 
ATOM   7412 C  CB  . LYS D 2 56  ? -48.319 -11.132 49.678  1    65.5   ? 226 LYS D CB  1 
ATOM   7413 C  CG  . LYS D 2 56  ? -48.38  -11.932 50.98   1    73.3   ? 226 LYS D CG  1 
ATOM   7414 C  CD  . LYS D 2 56  ? -49.635 -12.758 51.279  1    75.04  ? 226 LYS D CD  1 
ATOM   7415 C  CE  . LYS D 2 56  ? -50.594 -12.053 52.171  1    76.82  ? 226 LYS D CE  1 
ATOM   7416 N  NZ  . LYS D 2 56  ? -51.694 -12.943 52.569  1    81.22  ? 226 LYS D NZ  1 
ATOM   7417 N  N   . LEU D 2 57  ? -46.524 -11.49  46.369  1    49.91  ? 227 LEU D N   1 
ATOM   7418 C  CA  . LEU D 2 57  ? -46.171 -10.785 45.144  1    51.71  ? 227 LEU D CA  1 
ATOM   7419 C  C   . LEU D 2 57  ? -47.309 -10.932 44.146  1    50.59  ? 227 LEU D C   1 
ATOM   7420 O  O   . LEU D 2 57  ? -48.098 -11.856 44.277  1    54.67  ? 227 LEU D O   1 
ATOM   7421 C  CB  . LEU D 2 57  ? -44.885 -11.376 44.564  1    45.6   ? 227 LEU D CB  1 
ATOM   7422 C  CG  . LEU D 2 57  ? -43.676 -11.335 45.499  1    45.85  ? 227 LEU D CG  1 
ATOM   7423 C  CD1 . LEU D 2 57  ? -42.455 -11.84  44.755  1    38.63  ? 227 LEU D CD1 1 
ATOM   7424 C  CD2 . LEU D 2 57  ? -43.481 -9.923  46.08   1    42.62  ? 227 LEU D CD2 1 
ATOM   7425 N  N   . GLN D 2 58  ? -47.347 -10.046 43.14   1    49.69  ? 228 GLN D N   1 
ATOM   7426 C  CA  . GLN D 2 58  ? -48.319 -10.157 42.062  1    47.77  ? 228 GLN D CA  1 
ATOM   7427 C  C   . GLN D 2 58  ? -48.018 -11.405 41.247  1    49.57  ? 228 GLN D C   1 
ATOM   7428 O  O   . GLN D 2 58  ? -46.858 -11.795 41.134  1    52     ? 228 GLN D O   1 
ATOM   7429 C  CB  . GLN D 2 58  ? -48.287 -8.925  41.166  1    42.43  ? 228 GLN D CB  1 
ATOM   7430 C  CG  . GLN D 2 58  ? -48.693 -7.65   41.884  1    43.73  ? 228 GLN D CG  1 
ATOM   7431 C  CD  . GLN D 2 58  ? -50.129 -7.707  42.333  1    48.63  ? 228 GLN D CD  1 
ATOM   7432 O  OE1 . GLN D 2 58  ? -51.058 -7.643  41.521  1    55.37  ? 228 GLN D OE1 1 
ATOM   7433 N  NE2 . GLN D 2 58  ? -50.314 -7.883  43.631  1    47.84  ? 228 GLN D NE2 1 
ATOM   7434 N  N   . ASN D 2 59  ? -49.064 -12.007 40.674  1    53.08  ? 229 ASN D N   1 
ATOM   7435 C  CA  . ASN D 2 59  ? -48.865 -13.098 39.731  1    51.6   ? 229 ASN D CA  1 
ATOM   7436 C  C   . ASN D 2 59  ? -48.067 -12.646 38.519  1    46.76  ? 229 ASN D C   1 
ATOM   7437 O  O   . ASN D 2 59  ? -47.269 -13.445 38.015  1    45.38  ? 229 ASN D O   1 
ATOM   7438 C  CB  . ASN D 2 59  ? -50.164 -13.774 39.321  1    51.68  ? 229 ASN D CB  1 
ATOM   7439 C  CG  . ASN D 2 59  ? -50.737 -14.591 40.454  1    52.41  ? 229 ASN D CG  1 
ATOM   7440 O  OD1 . ASN D 2 59  ? -49.996 -15.098 41.31   1    51     ? 229 ASN D OD1 1 
ATOM   7441 N  ND2 . ASN D 2 59  ? -52.051 -14.7   40.482  1    51.22  ? 229 ASN D ND2 1 
ATOM   7442 N  N   . GLU D 2 60  ? -48.282 -11.382 38.099  1    46     ? 230 GLU D N   1 
ATOM   7443 C  CA  . GLU D 2 60  ? -47.566 -10.79  36.975  1    46.61  ? 230 GLU D CA  1 
ATOM   7444 C  C   . GLU D 2 60  ? -46.053 -10.767 37.226  1    47     ? 230 GLU D C   1 
ATOM   7445 O  O   . GLU D 2 60  ? -45.262 -10.9   36.285  1    44.88  ? 230 GLU D O   1 
ATOM   7446 C  CB  . GLU D 2 60  ? -48.15  -9.422  36.639  1    46.81  ? 230 GLU D CB  1 
ATOM   7447 C  CG  . GLU D 2 60  ? -47.349 -8.616  35.614  1    48.4   ? 230 GLU D CG  1 
ATOM   7448 C  CD  . GLU D 2 60  ? -47.403 -9.154  34.19   1    47.26  ? 230 GLU D CD  1 
ATOM   7449 O  OE1 . GLU D 2 60  ? -48.116 -10.142 33.978  1    47     ? 230 GLU D OE1 1 
ATOM   7450 O  OE2 . GLU D 2 60  ? -46.774 -8.567  33.296  1    45.41  ? 230 GLU D OE2 1 
ATOM   7451 N  N   . THR D 2 61  ? -45.655 -10.601 38.501  1    44.59  ? 231 THR D N   1 
ATOM   7452 C  CA  . THR D 2 61  ? -44.243 -10.534 38.872  1    44.61  ? 231 THR D CA  1 
ATOM   7453 C  C   . THR D 2 61  ? -43.578 -11.893 38.624  1    44.93  ? 231 THR D C   1 
ATOM   7454 O  O   . THR D 2 61  ? -42.449 -11.937 38.162  1    50.96  ? 231 THR D O   1 
ATOM   7455 C  CB  . THR D 2 61  ? -44.085 -10.09  40.334  1    46.36  ? 231 THR D CB  1 
ATOM   7456 O  OG1 . THR D 2 61  ? -44.689 -8.815  40.508  1    45.6   ? 231 THR D OG1 1 
ATOM   7457 C  CG2 . THR D 2 61  ? -42.642 -9.975  40.791  1    40.92  ? 231 THR D CG2 1 
ATOM   7458 N  N   . LEU D 2 62  ? -44.266 -12.987 38.972  1    42.56  ? 232 LEU D N   1 
ATOM   7459 C  CA  . LEU D 2 62  ? -43.81  -14.351 38.754  1    41.39  ? 232 LEU D CA  1 
ATOM   7460 C  C   . LEU D 2 62  ? -43.635 -14.629 37.265  1    39.72  ? 232 LEU D C   1 
ATOM   7461 O  O   . LEU D 2 62  ? -42.632 -15.192 36.861  1    41.57  ? 232 LEU D O   1 
ATOM   7462 C  CB  . LEU D 2 62  ? -44.821 -15.309 39.39   1    44.02  ? 232 LEU D CB  1 
ATOM   7463 C  CG  . LEU D 2 62  ? -44.635 -16.798 39.1    1    42.78  ? 232 LEU D CG  1 
ATOM   7464 C  CD1 . LEU D 2 62  ? -43.337 -17.283 39.661  1    44.25  ? 232 LEU D CD1 1 
ATOM   7465 C  CD2 . LEU D 2 62  ? -45.768 -17.605 39.677  1    45.26  ? 232 LEU D CD2 1 
ATOM   7466 N  N   . HIS D 2 63  ? -44.619 -14.242 36.443  1    46.07  ? 233 HIS D N   1 
ATOM   7467 C  CA  . HIS D 2 63  ? -44.526 -14.439 34.994  1    46.41  ? 233 HIS D CA  1 
ATOM   7468 C  C   . HIS D 2 63  ? -43.311 -13.71  34.409  1    45.13  ? 233 HIS D C   1 
ATOM   7469 O  O   . HIS D 2 63  ? -42.6   -14.283 33.575  1    49.62  ? 233 HIS D O   1 
ATOM   7470 C  CB  . HIS D 2 63  ? -45.835 -14.055 34.287  1    45.02  ? 233 HIS D CB  1 
ATOM   7471 C  CG  . HIS D 2 63  ? -46.921 -15.068 34.36   1    45.7   ? 233 HIS D CG  1 
ATOM   7472 N  ND1 . HIS D 2 63  ? -47.694 -15.24  35.496  1    49.01  ? 233 HIS D ND1 1 
ATOM   7473 C  CD2 . HIS D 2 63  ? -47.364 -15.935 33.449  1    41.81  ? 233 HIS D CD2 1 
ATOM   7474 C  CE1 . HIS D 2 63  ? -48.577 -16.194 35.271  1    47.68  ? 233 HIS D CE1 1 
ATOM   7475 N  NE2 . HIS D 2 63  ? -48.395 -16.634 34.043  1    46.38  ? 233 HIS D NE2 1 
ATOM   7476 N  N   . LEU D 2 64  ? -43.069 -12.467 34.877  1    41.31  ? 234 LEU D N   1 
ATOM   7477 C  CA  . LEU D 2 64  ? -41.953 -11.675 34.404  1    41.22  ? 234 LEU D CA  1 
ATOM   7478 C  C   . LEU D 2 64  ? -40.626 -12.356 34.743  1    46.75  ? 234 LEU D C   1 
ATOM   7479 O  O   . LEU D 2 64  ? -39.742 -12.475 33.88   1    49.84  ? 234 LEU D O   1 
ATOM   7480 C  CB  . LEU D 2 64  ? -42.024 -10.285 35.007  1    36.8   ? 234 LEU D CB  1 
ATOM   7481 C  CG  . LEU D 2 64  ? -43.107 -9.382  34.418  1    41.87  ? 234 LEU D CG  1 
ATOM   7482 C  CD1 . LEU D 2 64  ? -43.243 -8.103  35.279  1    39.75  ? 234 LEU D CD1 1 
ATOM   7483 C  CD2 . LEU D 2 64  ? -42.789 -9.039  32.953  1    32.88  ? 234 LEU D CD2 1 
ATOM   7484 N  N   . ALA D 2 65  ? -40.49  -12.776 36.012  1    45.73  ? 235 ALA D N   1 
ATOM   7485 C  CA  . ALA D 2 65  ? -39.258 -13.401 36.477  1    43.57  ? 235 ALA D CA  1 
ATOM   7486 C  C   . ALA D 2 65  ? -38.887 -14.577 35.574  1    41.67  ? 235 ALA D C   1 
ATOM   7487 O  O   . ALA D 2 65  ? -37.733 -14.707 35.203  1    44.13  ? 235 ALA D O   1 
ATOM   7488 C  CB  . ALA D 2 65  ? -39.387 -13.817 37.928  1    40.41  ? 235 ALA D CB  1 
ATOM   7489 N  N   . VAL D 2 66  ? -39.88  -15.401 35.205  1    39.72  ? 236 VAL D N   1 
ATOM   7490 C  CA  . VAL D 2 66  ? -39.641 -16.596 34.425  1    40.14  ? 236 VAL D CA  1 
ATOM   7491 C  C   . VAL D 2 66  ? -39.183 -16.193 33.023  1    42.43  ? 236 VAL D C   1 
ATOM   7492 O  O   . VAL D 2 66  ? -38.263 -16.789 32.444  1    49.09  ? 236 VAL D O   1 
ATOM   7493 C  CB  . VAL D 2 66  ? -40.858 -17.538 34.384  1    44.7   ? 236 VAL D CB  1 
ATOM   7494 C  CG1 . VAL D 2 66  ? -40.595 -18.686 33.432  1    37.7   ? 236 VAL D CG1 1 
ATOM   7495 C  CG2 . VAL D 2 66  ? -41.291 -18.077 35.764  1    44.12  ? 236 VAL D CG2 1 
ATOM   7496 N  N   . ASN D 2 67  ? -39.838 -15.182 32.454  1    41.95  ? 237 ASN D N   1 
ATOM   7497 C  CA  . ASN D 2 67  ? -39.436 -14.675 31.151  1    40.43  ? 237 ASN D CA  1 
ATOM   7498 C  C   . ASN D 2 67  ? -37.947 -14.285 31.189  1    45.54  ? 237 ASN D C   1 
ATOM   7499 O  O   . ASN D 2 67  ? -37.179 -14.588 30.254  1    39.45  ? 237 ASN D O   1 
ATOM   7500 C  CB  . ASN D 2 67  ? -40.343 -13.53  30.727  1    37.83  ? 237 ASN D CB  1 
ATOM   7501 C  CG  . ASN D 2 67  ? -39.895 -12.917 29.422  1    42.1   ? 237 ASN D CG  1 
ATOM   7502 O  OD1 . ASN D 2 67  ? -39.176 -11.908 29.408  1    45.66  ? 237 ASN D OD1 1 
ATOM   7503 N  ND2 . ASN D 2 67  ? -40.245 -13.545 28.311  1    43.46  ? 237 ASN D ND2 1 
ATOM   7504 N  N   . TYR D 2 68  ? -37.538 -13.617 32.294  1    41.91  ? 238 TYR D N   1 
ATOM   7505 C  CA  . TYR D 2 68  ? -36.191 -13.085 32.422  1    41.01  ? 238 TYR D CA  1 
ATOM   7506 C  C   . TYR D 2 68  ? -35.177 -14.229 32.429  1    44.32  ? 238 TYR D C   1 
ATOM   7507 O  O   . TYR D 2 68  ? -34.149 -14.179 31.735  1    44.79  ? 238 TYR D O   1 
ATOM   7508 C  CB  . TYR D 2 68  ? -36.03  -12.209 33.66   1    35.71  ? 238 TYR D CB  1 
ATOM   7509 C  CG  . TYR D 2 68  ? -36.91  -10.971 33.698  1    36.9   ? 238 TYR D CG  1 
ATOM   7510 C  CD1 . TYR D 2 68  ? -37.577 -10.514 32.566  1    36.82  ? 238 TYR D CD1 1 
ATOM   7511 C  CD2 . TYR D 2 68  ? -37.072 -10.269 34.891  1    38.97  ? 238 TYR D CD2 1 
ATOM   7512 C  CE1 . TYR D 2 68  ? -38.364 -9.372  32.6    1    36.83  ? 238 TYR D CE1 1 
ATOM   7513 C  CE2 . TYR D 2 68  ? -37.894 -9.16   34.953  1    40.3   ? 238 TYR D CE2 1 
ATOM   7514 C  CZ  . TYR D 2 68  ? -38.543 -8.719  33.809  1    39.64  ? 238 TYR D CZ  1 
ATOM   7515 O  OH  . TYR D 2 68  ? -39.351 -7.628  33.888  1    42.23  ? 238 TYR D OH  1 
ATOM   7516 N  N   . ILE D 2 69  ? -35.514 -15.267 33.202  1    43.72  ? 239 ILE D N   1 
ATOM   7517 C  CA  . ILE D 2 69  ? -34.696 -16.458 33.335  1    40.64  ? 239 ILE D CA  1 
ATOM   7518 C  C   . ILE D 2 69  ? -34.542 -17.145 31.977  1    44.15  ? 239 ILE D C   1 
ATOM   7519 O  O   . ILE D 2 69  ? -33.433 -17.452 31.56   1    45.6   ? 239 ILE D O   1 
ATOM   7520 C  CB  . ILE D 2 69  ? -35.299 -17.382 34.391  1    38.89  ? 239 ILE D CB  1 
ATOM   7521 C  CG1 . ILE D 2 69  ? -35.319 -16.66  35.788  1    36.24  ? 239 ILE D CG1 1 
ATOM   7522 C  CG2 . ILE D 2 69  ? -34.522 -18.693 34.411  1    36.36  ? 239 ILE D CG2 1 
ATOM   7523 C  CD1 . ILE D 2 69  ? -36.252 -17.299 36.801  1    31.95  ? 239 ILE D CD1 1 
ATOM   7524 N  N   . ASP D 2 70  ? -35.643 -17.35  31.255  1    44.75  ? 240 ASP D N   1 
ATOM   7525 C  CA  . ASP D 2 70  ? -35.592 -18.104 30.006  1    45.89  ? 240 ASP D CA  1 
ATOM   7526 C  C   . ASP D 2 70  ? -34.737 -17.369 28.976  1    40.77  ? 240 ASP D C   1 
ATOM   7527 O  O   . ASP D 2 70  ? -33.971 -18.002 28.254  1    38.49  ? 240 ASP D O   1 
ATOM   7528 C  CB  . ASP D 2 70  ? -36.99  -18.49  29.538  1    46.96  ? 240 ASP D CB  1 
ATOM   7529 C  CG  . ASP D 2 70  ? -37.691 -19.539 30.391  1    49.01  ? 240 ASP D CG  1 
ATOM   7530 O  OD1 . ASP D 2 70  ? -36.95  -20.369 30.978  1    48     ? 240 ASP D OD1 1 
ATOM   7531 O  OD2 . ASP D 2 70  ? -38.964 -19.518 30.459  1    45.3   ? 240 ASP D OD2 1 
ATOM   7532 N  N   . ARG D 2 71  ? -34.837 -16.033 28.933  1    41.06  ? 241 ARG D N   1 
ATOM   7533 C  CA  . ARG D 2 71  ? -34.055 -15.248 27.981  1    42.66  ? 241 ARG D CA  1 
ATOM   7534 C  C   . ARG D 2 71  ? -32.581 -15.233 28.373  1    44.56  ? 241 ARG D C   1 
ATOM   7535 O  O   . ARG D 2 71  ? -31.708 -15.314 27.497  1    50.85  ? 241 ARG D O   1 
ATOM   7536 C  CB  . ARG D 2 71  ? -34.566 -13.814 27.833  1    40.62  ? 241 ARG D CB  1 
ATOM   7537 C  CG  . ARG D 2 71  ? -35.858 -13.73  27.024  1    45.54  ? 241 ARG D CG  1 
ATOM   7538 C  CD  . ARG D 2 71  ? -36.741 -12.554 27.445  1    44.57  ? 241 ARG D CD  1 
ATOM   7539 N  NE  . ARG D 2 71  ? -36.119 -11.322 26.953  1    46.47  ? 241 ARG D NE  1 
ATOM   7540 C  CZ  . ARG D 2 71  ? -36.394 -10.126 27.456  1    44.3   ? 241 ARG D CZ  1 
ATOM   7541 N  NH1 . ARG D 2 71  ? -37.345 -9.972  28.377  1    48.3   ? 241 ARG D NH1 1 
ATOM   7542 N  NH2 . ARG D 2 71  ? -35.698 -9.093  27.045  1    38.68  ? 241 ARG D NH2 1 
ATOM   7543 N  N   . PHE D 2 72  ? -32.326 -15.147 29.689  1    39.76  ? 242 PHE D N   1 
ATOM   7544 C  CA  . PHE D 2 72  ? -30.966 -15.171 30.205  1    39.92  ? 242 PHE D CA  1 
ATOM   7545 C  C   . PHE D 2 72  ? -30.297 -16.489 29.828  1    43.04  ? 242 PHE D C   1 
ATOM   7546 O  O   . PHE D 2 72  ? -29.138 -16.51  29.405  1    45.14  ? 242 PHE D O   1 
ATOM   7547 C  CB  . PHE D 2 72  ? -30.936 -15.009 31.736  1    40.22  ? 242 PHE D CB  1 
ATOM   7548 C  CG  . PHE D 2 72  ? -29.532 -14.794 32.286  1    38.19  ? 242 PHE D CG  1 
ATOM   7549 C  CD1 . PHE D 2 72  ? -28.952 -13.535 32.297  1    39.47  ? 242 PHE D CD1 1 
ATOM   7550 C  CD2 . PHE D 2 72  ? -28.778 -15.869 32.74   1    39.97  ? 242 PHE D CD2 1 
ATOM   7551 C  CE1 . PHE D 2 72  ? -27.666 -13.367 32.778  1    44.15  ? 242 PHE D CE1 1 
ATOM   7552 C  CE2 . PHE D 2 72  ? -27.493 -15.7   33.225  1    37.81  ? 242 PHE D CE2 1 
ATOM   7553 C  CZ  . PHE D 2 72  ? -26.947 -14.45  33.25   1    41.63  ? 242 PHE D CZ  1 
ATOM   7554 N  N   . LEU D 2 73  ? -31.006 -17.587 30.07   1    43.01  ? 243 LEU D N   1 
ATOM   7555 C  CA  . LEU D 2 73  ? -30.42  -18.931 29.843  1    45.2   ? 243 LEU D CA  1 
ATOM   7556 C  C   . LEU D 2 73  ? -30.397 -19.254 28.346  1    43.48  ? 243 LEU D C   1 
ATOM   7557 O  O   . LEU D 2 73  ? -29.737 -20.227 27.97   1    45.95  ? 243 LEU D O   1 
ATOM   7558 C  CB  . LEU D 2 73  ? -31.239 -19.929 30.653  1    45.23  ? 243 LEU D CB  1 
ATOM   7559 C  CG  . LEU D 2 73  ? -31.129 -19.822 32.174  1    43.06  ? 243 LEU D CG  1 
ATOM   7560 C  CD1 . LEU D 2 73  ? -32.077 -20.821 32.799  1    45.19  ? 243 LEU D CD1 1 
ATOM   7561 C  CD2 . LEU D 2 73  ? -29.709 -20.11  32.592  1    45.56  ? 243 LEU D CD2 1 
ATOM   7562 N  N   . SER D 2 74  ? -31.08  -18.458 27.534  1    45.05  ? 244 SER D N   1 
ATOM   7563 C  CA  . SER D 2 74  ? -31.02  -18.625 26.062  1    48.09  ? 244 SER D CA  1 
ATOM   7564 C  C   . SER D 2 74  ? -29.724 -17.994 25.542  1    46.49  ? 244 SER D C   1 
ATOM   7565 O  O   . SER D 2 74  ? -29.386 -18.225 24.379  1    46.02  ? 244 SER D O   1 
ATOM   7566 C  CB  . SER D 2 74  ? -32.222 -18     25.42   1    45.06  ? 244 SER D CB  1 
ATOM   7567 O  OG  . SER D 2 74  ? -33.421 -18.642 25.822  1    48.84  ? 244 SER D OG  1 
ATOM   7568 N  N   . SER D 2 75  ? -29.002 -17.268 26.393  1    45.67  ? 245 SER D N   1 
ATOM   7569 C  CA  . SER D 2 75  ? -27.804 -16.529 25.931  1    50.19  ? 245 SER D CA  1 
ATOM   7570 C  C   . SER D 2 75  ? -26.576 -16.839 26.791  1    47.82  ? 245 SER D C   1 
ATOM   7571 O  O   . SER D 2 75  ? -25.461 -16.581 26.326  1    51.7   ? 245 SER D O   1 
ATOM   7572 C  CB  . SER D 2 75  ? -28.088 -15.06  25.944  1    52.76  ? 245 SER D CB  1 
ATOM   7573 O  OG  . SER D 2 75  ? -28.332 -14.586 27.26   1    60.17  ? 245 SER D OG  1 
ATOM   7574 N  N   . MET D 2 76  ? -26.77  -17.37  27.99   1    46.03  ? 246 MET D N   1 
ATOM   7575 C  CA  . MET D 2 76  ? -25.617 -17.561 28.903  1    44.9   ? 246 MET D CA  1 
ATOM   7576 C  C   . MET D 2 76  ? -25.615 -18.969 29.505  1    50.56  ? 246 MET D C   1 
ATOM   7577 O  O   . MET D 2 76  ? -26.67  -19.419 29.973  1    53.02  ? 246 MET D O   1 
ATOM   7578 C  CB  . MET D 2 76  ? -25.661 -16.538 30.04   1    44.05  ? 246 MET D CB  1 
ATOM   7579 C  CG  . MET D 2 76  ? -25.829 -15.11  29.59   1    46.01  ? 246 MET D CG  1 
ATOM   7580 S  SD  . MET D 2 76  ? -24.212 -14.414 29.214  1    50.85  ? 246 MET D SD  1 
ATOM   7581 C  CE  . MET D 2 76  ? -23.559 -14.323 30.885  1    44.36  ? 246 MET D CE  1 
ATOM   7582 N  N   . SER D 2 77  ? -24.458 -19.622 29.492  1    44     ? 247 SER D N   1 
ATOM   7583 C  CA  . SER D 2 77  ? -24.324 -20.972 30.081  1    42.02  ? 247 SER D CA  1 
ATOM   7584 C  C   . SER D 2 77  ? -24.198 -20.831 31.599  1    42.39  ? 247 SER D C   1 
ATOM   7585 O  O   . SER D 2 77  ? -23.37  -20.032 32.041  1    45.24  ? 247 SER D O   1 
ATOM   7586 C  CB  . SER D 2 77  ? -23.161 -21.709 29.477  1    41.95  ? 247 SER D CB  1 
ATOM   7587 O  OG  . SER D 2 77  ? -23.325 -21.886 28.079  1    46.82  ? 247 SER D OG  1 
ATOM   7588 N  N   . VAL D 2 78  ? -24.996 -21.58  32.356  1    43.96  ? 248 VAL D N   1 
ATOM   7589 C  CA  . VAL D 2 78  ? -25.001 -21.445 33.802  1    46.38  ? 248 VAL D CA  1 
ATOM   7590 C  C   . VAL D 2 78  ? -24.804 -22.813 34.452  1    51.85  ? 248 VAL D C   1 
ATOM   7591 O  O   . VAL D 2 78  ? -25.474 -23.768 34.093  1    56.89  ? 248 VAL D O   1 
ATOM   7592 C  CB  . VAL D 2 78  ? -26.318 -20.796 34.25   1    44.66  ? 248 VAL D CB  1 
ATOM   7593 C  CG1 . VAL D 2 78  ? -26.465 -20.817 35.762  1    39.83  ? 248 VAL D CG1 1 
ATOM   7594 C  CG2 . VAL D 2 78  ? -26.446 -19.373 33.704  1    38.59  ? 248 VAL D CG2 1 
ATOM   7595 N  N   . LEU D 2 79  ? -23.933 -22.873 35.456  1    54.07  ? 249 LEU D N   1 
ATOM   7596 C  CA  . LEU D 2 79  ? -23.741 -24.135 36.21   1    51.4   ? 249 LEU D CA  1 
ATOM   7597 C  C   . LEU D 2 79  ? -24.906 -24.316 37.197  1    54.24  ? 249 LEU D C   1 
ATOM   7598 O  O   . LEU D 2 79  ? -25.491 -23.306 37.607  1    53.94  ? 249 LEU D O   1 
ATOM   7599 C  CB  . LEU D 2 79  ? -22.381 -24.098 36.896  1    46.65  ? 249 LEU D CB  1 
ATOM   7600 C  CG  . LEU D 2 79  ? -21.162 -24.126 35.972  1    51.07  ? 249 LEU D CG  1 
ATOM   7601 C  CD1 . LEU D 2 79  ? -19.966 -24.668 36.725  1    50.62  ? 249 LEU D CD1 1 
ATOM   7602 C  CD2 . LEU D 2 79  ? -21.425 -24.948 34.725  1    47.35  ? 249 LEU D CD2 1 
ATOM   7603 N  N   . ARG D 2 80  ? -25.217 -25.555 37.579  1    56.41  ? 250 ARG D N   1 
ATOM   7604 C  CA  . ARG D 2 80  ? -26.395 -25.841 38.443  1    54.88  ? 250 ARG D CA  1 
ATOM   7605 C  C   . ARG D 2 80  ? -26.356 -25.047 39.757  1    53.26  ? 250 ARG D C   1 
ATOM   7606 O  O   . ARG D 2 80  ? -27.432 -24.681 40.249  1    51.03  ? 250 ARG D O   1 
ATOM   7607 C  CB  . ARG D 2 80  ? -26.456 -27.349 38.702  1    52.23  ? 250 ARG D CB  1 
ATOM   7608 C  CG  . ARG D 2 80  ? -27.663 -27.828 39.491  1    55.33  ? 250 ARG D CG  1 
ATOM   7609 C  CD  . ARG D 2 80  ? -27.351 -29.077 40.292  1    65.58  ? 250 ARG D CD  1 
ATOM   7610 N  NE  . ARG D 2 80  ? -25.935 -29.449 40.22   1    67.7   ? 250 ARG D NE  1 
ATOM   7611 C  CZ  . ARG D 2 80  ? -25.492 -30.697 40.21   1    70.3   ? 250 ARG D CZ  1 
ATOM   7612 N  NH1 . ARG D 2 80  ? -26.025 -31.58  39.387  1    67.39  ? 250 ARG D NH1 1 
ATOM   7613 N  NH2 . ARG D 2 80  ? -24.518 -31.057 41.023  1    65.11  ? 250 ARG D NH2 1 
ATOM   7614 N  N   . GLY D 2 81  ? -25.171 -24.793 40.298  1    53.51  ? 251 GLY D N   1 
ATOM   7615 C  CA  . GLY D 2 81  ? -25.076 -24.121 41.603  1    51.36  ? 251 GLY D CA  1 
ATOM   7616 C  C   . GLY D 2 81  ? -25.309 -22.637 41.501  1    51.86  ? 251 GLY D C   1 
ATOM   7617 O  O   . GLY D 2 81  ? -25.308 -21.975 42.545  1    52.82  ? 251 GLY D O   1 
ATOM   7618 N  N   . LYS D 2 82  ? -25.501 -22.135 40.288  1    47.65  ? 252 LYS D N   1 
ATOM   7619 C  CA  . LYS D 2 82  ? -25.691 -20.684 40.087  1    43.47  ? 252 LYS D CA  1 
ATOM   7620 C  C   . LYS D 2 82  ? -27.073 -20.465 39.476  1    44.01  ? 252 LYS D C   1 
ATOM   7621 O  O   . LYS D 2 82  ? -27.441 -19.308 39.26   1    48.51  ? 252 LYS D O   1 
ATOM   7622 C  CB  . LYS D 2 82  ? -24.545 -20.167 39.217  1    42.42  ? 252 LYS D CB  1 
ATOM   7623 C  CG  . LYS D 2 82  ? -23.207 -20.085 39.917  1    45.62  ? 252 LYS D CG  1 
ATOM   7624 C  CD  . LYS D 2 82  ? -23.279 -19.195 41.148  1    43.26  ? 252 LYS D CD  1 
ATOM   7625 C  CE  . LYS D 2 82  ? -21.919 -18.782 41.579  1    41.08  ? 252 LYS D CE  1 
ATOM   7626 N  NZ  . LYS D 2 82  ? -21.03  -19.943 41.559  1    47.16  ? 252 LYS D NZ  1 
ATOM   7627 N  N   . LEU D 2 83  ? -27.797 -21.548 39.219  1    41.82  ? 253 LEU D N   1 
ATOM   7628 C  CA  . LEU D 2 83  ? -29.157 -21.44  38.647  1    39.41  ? 253 LEU D CA  1 
ATOM   7629 C  C   . LEU D 2 83  ? -30.048 -20.698 39.644  1    40.52  ? 253 LEU D C   1 
ATOM   7630 O  O   . LEU D 2 83  ? -30.841 -19.856 39.207  1    41.94  ? 253 LEU D O   1 
ATOM   7631 C  CB  . LEU D 2 83  ? -29.714 -22.823 38.323  1    43.49  ? 253 LEU D CB  1 
ATOM   7632 C  CG  . LEU D 2 83  ? -31.089 -22.864 37.655  1    44.6   ? 253 LEU D CG  1 
ATOM   7633 C  CD1 . LEU D 2 83  ? -31.043 -22.175 36.307  1    40.6   ? 253 LEU D CD1 1 
ATOM   7634 C  CD2 . LEU D 2 83  ? -31.545 -24.301 37.505  1    44.11  ? 253 LEU D CD2 1 
ATOM   7635 N  N   . GLN D 2 84  ? -29.913 -20.995 40.931  1    40.28  ? 254 GLN D N   1 
ATOM   7636 C  CA  . GLN D 2 84  ? -30.759 -20.254 41.855  1    43.43  ? 254 GLN D CA  1 
ATOM   7637 C  C   . GLN D 2 84  ? -30.378 -18.775 41.874  1    42.66  ? 254 GLN D C   1 
ATOM   7638 O  O   . GLN D 2 84  ? -31.237 -17.9   42.029  1    42.28  ? 254 GLN D O   1 
ATOM   7639 C  CB  . GLN D 2 84  ? -30.699 -20.824 43.266  1    44.27  ? 254 GLN D CB  1 
ATOM   7640 C  CG  . GLN D 2 84  ? -31.829 -20.325 44.15   1    44.55  ? 254 GLN D CG  1 
ATOM   7641 C  CD  . GLN D 2 84  ? -31.928 -21.077 45.467  1    46.95  ? 254 GLN D CD  1 
ATOM   7642 O  OE1 . GLN D 2 84  ? -32.922 -20.927 46.192  1    48.8   ? 254 GLN D OE1 1 
ATOM   7643 N  NE2 . GLN D 2 84  ? -30.93  -21.903 45.771  1    40.79  ? 254 GLN D NE2 1 
ATOM   7644 N  N   . LEU D 2 85  ? -29.084 -18.493 41.71   1    40.24  ? 255 LEU D N   1 
ATOM   7645 C  CA  . LEU D 2 85  ? -28.643 -17.11  41.75   1    39.88  ? 255 LEU D CA  1 
ATOM   7646 C  C   . LEU D 2 85  ? -29.275 -16.341 40.59   1    41.95  ? 255 LEU D C   1 
ATOM   7647 O  O   . LEU D 2 85  ? -29.669 -15.201 40.75   1    42.8   ? 255 LEU D O   1 
ATOM   7648 C  CB  . LEU D 2 85  ? -27.121 -17.064 41.694  1    42.67  ? 255 LEU D CB  1 
ATOM   7649 C  CG  . LEU D 2 85  ? -26.528 -15.66  41.786  1    44.64  ? 255 LEU D CG  1 
ATOM   7650 C  CD1 . LEU D 2 85  ? -27.011 -14.997 43.076  1    44.07  ? 255 LEU D CD1 1 
ATOM   7651 C  CD2 . LEU D 2 85  ? -25.02  -15.711 41.732  1    42.75  ? 255 LEU D CD2 1 
ATOM   7652 N  N   . VAL D 2 86  ? -29.421 -16.973 39.414  1    42.95  ? 256 VAL D N   1 
ATOM   7653 C  CA  . VAL D 2 86  ? -30.098 -16.32  38.305  1    38.99  ? 256 VAL D CA  1 
ATOM   7654 C  C   . VAL D 2 86  ? -31.564 -16.049 38.671  1    39.76  ? 256 VAL D C   1 
ATOM   7655 O  O   . VAL D 2 86  ? -32.075 -14.939 38.528  1    36.63  ? 256 VAL D O   1 
ATOM   7656 C  CB  . VAL D 2 86  ? -30     -17.169 37.027  1    38.78  ? 256 VAL D CB  1 
ATOM   7657 C  CG1 . VAL D 2 86  ? -30.785 -16.509 35.894  1    32.59  ? 256 VAL D CG1 1 
ATOM   7658 C  CG2 . VAL D 2 86  ? -28.541 -17.418 36.645  1    38.55  ? 256 VAL D CG2 1 
ATOM   7659 N  N   . GLY D 2 87  ? -32.241 -17.095 39.149  1    39.52  ? 257 GLY D N   1 
ATOM   7660 C  CA  . GLY D 2 87  ? -33.634 -17.004 39.541  1    39.88  ? 257 GLY D CA  1 
ATOM   7661 C  C   . GLY D 2 87  ? -33.882 -15.892 40.559  1    43.11  ? 257 GLY D C   1 
ATOM   7662 O  O   . GLY D 2 87  ? -34.868 -15.174 40.435  1    42.79  ? 257 GLY D O   1 
ATOM   7663 N  N   . THR D 2 88  ? -32.989 -15.753 41.551  1    39.64  ? 258 THR D N   1 
ATOM   7664 C  CA  . THR D 2 88  ? -33.193 -14.786 42.62   1    40.69  ? 258 THR D CA  1 
ATOM   7665 C  C   . THR D 2 88  ? -33.104 -13.388 42.012  1    38.72  ? 258 THR D C   1 
ATOM   7666 O  O   . THR D 2 88  ? -33.934 -12.52  42.282  1    38.28  ? 258 THR D O   1 
ATOM   7667 C  CB  . THR D 2 88  ? -32.137 -14.983 43.715  1    40.54  ? 258 THR D CB  1 
ATOM   7668 O  OG1 . THR D 2 88  ? -32.249 -16.342 44.117  1    50.45  ? 258 THR D OG1 1 
ATOM   7669 C  CG2 . THR D 2 88  ? -32.394 -14.112 44.919  1    40.77  ? 258 THR D CG2 1 
ATOM   7670 N  N   . ALA D 2 89  ? -32.071 -13.183 41.191  1    36.08  ? 259 ALA D N   1 
ATOM   7671 C  CA  . ALA D 2 89  ? -31.846 -11.896 40.56   1    38.97  ? 259 ALA D CA  1 
ATOM   7672 C  C   . ALA D 2 89  ? -33.013 -11.541 39.637  1    40.67  ? 259 ALA D C   1 
ATOM   7673 O  O   . ALA D 2 89  ? -33.419 -10.377 39.585  1    43.62  ? 259 ALA D O   1 
ATOM   7674 C  CB  . ALA D 2 89  ? -30.533 -11.917 39.858  1    34     ? 259 ALA D CB  1 
ATOM   7675 N  N   . ALA D 2 90  ? -33.586 -12.552 38.96   1    37.4   ? 260 ALA D N   1 
ATOM   7676 C  CA  . ALA D 2 90  ? -34.71  -12.325 38.06   1    38.61  ? 260 ALA D CA  1 
ATOM   7677 C  C   . ALA D 2 90  ? -35.96  -11.926 38.844  1    42.91  ? 260 ALA D C   1 
ATOM   7678 O  O   . ALA D 2 90  ? -36.684 -11.005 38.455  1    50.73  ? 260 ALA D O   1 
ATOM   7679 C  CB  . ALA D 2 90  ? -34.943 -13.528 37.197  1    35.51  ? 260 ALA D CB  1 
ATOM   7680 N  N   . MET D 2 91  ? -36.209 -12.624 39.952  1    41.49  ? 261 MET D N   1 
ATOM   7681 C  CA  . MET D 2 91  ? -37.312 -12.285 40.833  1    39.4   ? 261 MET D CA  1 
ATOM   7682 C  C   . MET D 2 91  ? -37.135 -10.869 41.385  1    40.63  ? 261 MET D C   1 
ATOM   7683 O  O   . MET D 2 91  ? -38.076 -10.077 41.345  1    43.22  ? 261 MET D O   1 
ATOM   7684 C  CB  . MET D 2 91  ? -37.417 -13.264 42.002  1    38.87  ? 261 MET D CB  1 
ATOM   7685 C  CG  . MET D 2 91  ? -38.792 -13.282 42.629  1    44.09  ? 261 MET D CG  1 
ATOM   7686 S  SD  . MET D 2 91  ? -40.043 -13.636 41.38   1    48.71  ? 261 MET D SD  1 
ATOM   7687 C  CE  . MET D 2 91  ? -41.201 -14.574 42.38   1    45.71  ? 261 MET D CE  1 
ATOM   7688 N  N   . LEU D 2 92  ? -35.926 -10.542 41.86   1    37.03  ? 262 LEU D N   1 
ATOM   7689 C  CA  . LEU D 2 92  ? -35.633 -9.195  42.336  1    38.08  ? 262 LEU D CA  1 
ATOM   7690 C  C   . LEU D 2 92  ? -35.994 -8.136  41.279  1    37.99  ? 262 LEU D C   1 
ATOM   7691 O  O   . LEU D 2 92  ? -36.688 -7.164  41.579  1    37.37  ? 262 LEU D O   1 
ATOM   7692 C  CB  . LEU D 2 92  ? -34.163 -9.13   42.733  1    34.61  ? 262 LEU D CB  1 
ATOM   7693 C  CG  . LEU D 2 92  ? -33.63  -7.752  43.118  1    33.48  ? 262 LEU D CG  1 
ATOM   7694 C  CD1 . LEU D 2 92  ? -34.471 -7.104  44.228  1    33.61  ? 262 LEU D CD1 1 
ATOM   7695 C  CD2 . LEU D 2 92  ? -32.19  -7.85   43.549  1    31.46  ? 262 LEU D CD2 1 
ATOM   7696 N  N   . LEU D 2 93  ? -35.575 -8.365  40.034  1    37.84  ? 263 LEU D N   1 
ATOM   7697 C  CA  . LEU D 2 93  ? -35.754 -7.414  38.954  1    36.62  ? 263 LEU D CA  1 
ATOM   7698 C  C   . LEU D 2 93  ? -37.227 -7.264  38.63   1    40.42  ? 263 LEU D C   1 
ATOM   7699 O  O   . LEU D 2 93  ? -37.674 -6.13   38.395  1    42.83  ? 263 LEU D O   1 
ATOM   7700 C  CB  . LEU D 2 93  ? -34.962 -7.831  37.716  1    37.5   ? 263 LEU D CB  1 
ATOM   7701 C  CG  . LEU D 2 93  ? -33.474 -7.458  37.734  1    40.12  ? 263 LEU D CG  1 
ATOM   7702 C  CD1 . LEU D 2 93  ? -32.793 -8.093  36.542  1    37.93  ? 263 LEU D CD1 1 
ATOM   7703 C  CD2 . LEU D 2 93  ? -33.261 -5.927  37.711  1    39.55  ? 263 LEU D CD2 1 
ATOM   7704 N  N   . ALA D 2 94  ? -37.961 -8.397  38.626  1    35.62  ? 264 ALA D N   1 
ATOM   7705 C  CA  . ALA D 2 94  ? -39.381 -8.372  38.302  1    33.25  ? 264 ALA D CA  1 
ATOM   7706 C  C   . ALA D 2 94  ? -40.144 -7.602  39.368  1    38.76  ? 264 ALA D C   1 
ATOM   7707 O  O   . ALA D 2 94  ? -41.027 -6.812  39.036  1    46.61  ? 264 ALA D O   1 
ATOM   7708 C  CB  . ALA D 2 94  ? -39.921 -9.758  38.182  1    36.67  ? 264 ALA D CB  1 
ATOM   7709 N  N   . SER D 2 95  ? -39.808 -7.845  40.643  1    38.91  ? 265 SER D N   1 
ATOM   7710 C  CA  . SER D 2 95  ? -40.389 -7.119  41.761  1    39.01  ? 265 SER D CA  1 
ATOM   7711 C  C   . SER D 2 95  ? -40.181 -5.614  41.61   1    40.06  ? 265 SER D C   1 
ATOM   7712 O  O   . SER D 2 95  ? -41.137 -4.835  41.738  1    39.77  ? 265 SER D O   1 
ATOM   7713 C  CB  . SER D 2 95  ? -39.839 -7.614  43.049  1    41.37  ? 265 SER D CB  1 
ATOM   7714 O  OG  . SER D 2 95  ? -40.111 -9.001  43.204  1    47.31  ? 265 SER D OG  1 
ATOM   7715 N  N   . LYS D 2 96  ? -38.928 -5.204  41.355  1    39.93  ? 266 LYS D N   1 
ATOM   7716 C  CA  . LYS D 2 96  ? -38.643 -3.786  41.19   1    41.13  ? 266 LYS D CA  1 
ATOM   7717 C  C   . LYS D 2 96  ? -39.414 -3.215  39.997  1    40.28  ? 266 LYS D C   1 
ATOM   7718 O  O   . LYS D 2 96  ? -39.845 -2.064  40.055  1    44.88  ? 266 LYS D O   1 
ATOM   7719 C  CB  . LYS D 2 96  ? -37.138 -3.539  41.036  1    42.55  ? 266 LYS D CB  1 
ATOM   7720 C  CG  . LYS D 2 96  ? -36.23  -3.699  42.254  1    35.55  ? 266 LYS D CG  1 
ATOM   7721 C  CD  . LYS D 2 96  ? -34.779 -3.369  41.911  1    34.55  ? 266 LYS D CD  1 
ATOM   7722 C  CE  . LYS D 2 96  ? -33.814 -3.407  43.081  1    35.51  ? 266 LYS D CE  1 
ATOM   7723 N  NZ  . LYS D 2 96  ? -32.43  -3.165  42.673  1    35.08  ? 266 LYS D NZ  1 
ATOM   7724 N  N   . PHE D 2 97  ? -39.613 -4.016  38.932  1    34.36  ? 267 PHE D N   1 
ATOM   7725 C  CA  . PHE D 2 97  ? -40.321 -3.538  37.753  1    33.58  ? 267 PHE D CA  1 
ATOM   7726 C  C   . PHE D 2 97  ? -41.805 -3.366  38.058  1    34.99  ? 267 PHE D C   1 
ATOM   7727 O  O   . PHE D 2 97  ? -42.376 -2.333  37.753  1    34.64  ? 267 PHE D O   1 
ATOM   7728 C  CB  . PHE D 2 97  ? -40.137 -4.444  36.531  1    32.32  ? 267 PHE D CB  1 
ATOM   7729 C  CG  . PHE D 2 97  ? -40.83  -3.937  35.278  1    35.87  ? 267 PHE D CG  1 
ATOM   7730 C  CD1 . PHE D 2 97  ? -40.221 -3.029  34.425  1    41.53  ? 267 PHE D CD1 1 
ATOM   7731 C  CD2 . PHE D 2 97  ? -42.109 -4.372  34.941  1    37.93  ? 267 PHE D CD2 1 
ATOM   7732 C  CE1 . PHE D 2 97  ? -40.874 -2.603  33.254  1    48.19  ? 267 PHE D CE1 1 
ATOM   7733 C  CE2 . PHE D 2 97  ? -42.739 -3.98   33.762  1    38.6   ? 267 PHE D CE2 1 
ATOM   7734 C  CZ  . PHE D 2 97  ? -42.138 -3.077  32.918  1    44.14  ? 267 PHE D CZ  1 
ATOM   7735 N  N   . GLU D 2 98  ? -42.401 -4.362  38.721  1    38.87  ? 268 GLU D N   1 
ATOM   7736 C  CA  . GLU D 2 98  ? -43.848 -4.528  38.763  1    41.27  ? 268 GLU D CA  1 
ATOM   7737 C  C   . GLU D 2 98  ? -44.487 -4.116  40.09   1    43.93  ? 268 GLU D C   1 
ATOM   7738 O  O   . GLU D 2 98  ? -45.642 -3.711  40.068  1    50.96  ? 268 GLU D O   1 
ATOM   7739 C  CB  . GLU D 2 98  ? -44.207 -5.992  38.548  1    40.66  ? 268 GLU D CB  1 
ATOM   7740 C  CG  . GLU D 2 98  ? -45.661 -6.214  38.142  1    45.18  ? 268 GLU D CG  1 
ATOM   7741 C  CD  . GLU D 2 98  ? -46.175 -5.415  36.957  1    47.57  ? 268 GLU D CD  1 
ATOM   7742 O  OE1 . GLU D 2 98  ? -45.346 -5.158  36.077  1    47.18  ? 268 GLU D OE1 1 
ATOM   7743 O  OE2 . GLU D 2 98  ? -47.382 -5.075  36.884  1    46.69  ? 268 GLU D OE2 1 
ATOM   7744 N  N   . GLU D 2 99  ? -43.774 -4.241  41.223  1    40.72  ? 269 GLU D N   1 
ATOM   7745 C  CA  . GLU D 2 99  ? -44.427 -4.174  42.518  1    39.66  ? 269 GLU D CA  1 
ATOM   7746 C  C   . GLU D 2 99  ? -44.429 -2.732  42.976  1    44.72  ? 269 GLU D C   1 
ATOM   7747 O  O   . GLU D 2 99  ? -43.465 -2.009  42.77   1    50.2   ? 269 GLU D O   1 
ATOM   7748 C  CB  . GLU D 2 99  ? -43.669 -4.979  43.572  1    40.2   ? 269 GLU D CB  1 
ATOM   7749 C  CG  . GLU D 2 99  ? -43.772 -6.499  43.427  1    39.81  ? 269 GLU D CG  1 
ATOM   7750 C  CD  . GLU D 2 99  ? -45.132 -7.157  43.612  1    42.44  ? 269 GLU D CD  1 
ATOM   7751 O  OE1 . GLU D 2 99  ? -45.878 -6.764  44.53   1    50.36  ? 269 GLU D OE1 1 
ATOM   7752 O  OE2 . GLU D 2 99  ? -45.448 -8.092  42.866  1    38.93  ? 269 GLU D OE2 1 
ATOM   7753 N  N   . ILE D 2 100 ? -45.507 -2.333  43.651  1    47.22  ? 270 ILE D N   1 
ATOM   7754 C  CA  . ILE D 2 100 ? -45.535 -1.071  44.369  1    48.31  ? 270 ILE D CA  1 
ATOM   7755 C  C   . ILE D 2 100 ? -44.477 -1.055  45.486  1    54.32  ? 270 ILE D C   1 
ATOM   7756 O  O   . ILE D 2 100 ? -43.74  -0.08   45.639  1    53.53  ? 270 ILE D O   1 
ATOM   7757 C  CB  . ILE D 2 100 ? -46.948 -0.815  44.918  1    51.11  ? 270 ILE D CB  1 
ATOM   7758 C  CG1 . ILE D 2 100 ? -48.024 -0.832  43.827  1    49.91  ? 270 ILE D CG1 1 
ATOM   7759 C  CG2 . ILE D 2 100 ? -47.001 0.479   45.744  1    49.25  ? 270 ILE D CG2 1 
ATOM   7760 C  CD1 . ILE D 2 100 ? -49.44  -0.769  44.392  1    45.8   ? 270 ILE D CD1 1 
ATOM   7761 N  N   . TYR D 2 101 ? -44.432 -2.14   46.281  1    55.75  ? 271 TYR D N   1 
ATOM   7762 C  CA  . TYR D 2 101 ? -43.565 -2.285  47.441  1    53.11  ? 271 TYR D CA  1 
ATOM   7763 C  C   . TYR D 2 101 ? -42.727 -3.552  47.273  1    53.14  ? 271 TYR D C   1 
ATOM   7764 O  O   . TYR D 2 101 ? -43.057 -4.585  47.867  1    52.47  ? 271 TYR D O   1 
ATOM   7765 C  CB  . TYR D 2 101 ? -44.375 -2.419  48.74   1    52.43  ? 271 TYR D CB  1 
ATOM   7766 C  CG  . TYR D 2 101 ? -45.31  -1.261  49.031  1    54.55  ? 271 TYR D CG  1 
ATOM   7767 C  CD1 . TYR D 2 101 ? -44.803 -0.068  49.535  1    56.78  ? 271 TYR D CD1 1 
ATOM   7768 C  CD2 . TYR D 2 101 ? -46.687 -1.351  48.799  1    56.81  ? 271 TYR D CD2 1 
ATOM   7769 C  CE1 . TYR D 2 101 ? -45.626 1.02    49.789  1    59.98  ? 271 TYR D CE1 1 
ATOM   7770 C  CE2 . TYR D 2 101 ? -47.522 -0.27   49.056  1    62.06  ? 271 TYR D CE2 1 
ATOM   7771 C  CZ  . TYR D 2 101 ? -46.988 0.918   49.545  1    64.35  ? 271 TYR D CZ  1 
ATOM   7772 O  OH  . TYR D 2 101 ? -47.776 2.011   49.796  1    75.39  ? 271 TYR D OH  1 
ATOM   7773 N  N   . PRO D 2 102 ? -41.638 -3.533  46.454  1    51.15  ? 272 PRO D N   1 
ATOM   7774 C  CA  . PRO D 2 102 ? -40.799 -4.723  46.267  1    45.4   ? 272 PRO D CA  1 
ATOM   7775 C  C   . PRO D 2 102 ? -40.169 -5.109  47.602  1    46.31  ? 272 PRO D C   1 
ATOM   7776 O  O   . PRO D 2 102 ? -40.001 -4.263  48.487  1    49.62  ? 272 PRO D O   1 
ATOM   7777 C  CB  . PRO D 2 102 ? -39.751 -4.316  45.242  1    42.08  ? 272 PRO D CB  1 
ATOM   7778 C  CG  . PRO D 2 102 ? -39.743 -2.793  45.329  1    45.78  ? 272 PRO D CG  1 
ATOM   7779 C  CD  . PRO D 2 102 ? -41.169 -2.387  45.66   1    46.7   ? 272 PRO D CD  1 
ATOM   7780 N  N   . PRO D 2 103 ? -39.875 -6.406  47.83   1    44.22  ? 273 PRO D N   1 
ATOM   7781 C  CA  . PRO D 2 103 ? -39.084 -6.782  48.99   1    44.59  ? 273 PRO D CA  1 
ATOM   7782 C  C   . PRO D 2 103 ? -37.69  -6.18   48.8    1    49.91  ? 273 PRO D C   1 
ATOM   7783 O  O   . PRO D 2 103 ? -37.242 -5.913  47.677  1    48.36  ? 273 PRO D O   1 
ATOM   7784 C  CB  . PRO D 2 103 ? -39.109 -8.319  48.981  1    42.57  ? 273 PRO D CB  1 
ATOM   7785 C  CG  . PRO D 2 103 ? -40.258 -8.687  48.072  1    43.64  ? 273 PRO D CG  1 
ATOM   7786 C  CD  . PRO D 2 103 ? -40.339 -7.567  47.044  1    43.72  ? 273 PRO D CD  1 
ATOM   7787 N  N   . GLU D 2 104 ? -37.034 -5.927  49.939  1    52.01  ? 274 GLU D N   1 
ATOM   7788 C  CA  . GLU D 2 104 ? -35.674 -5.436  49.975  1    50.09  ? 274 GLU D CA  1 
ATOM   7789 C  C   . GLU D 2 104 ? -34.733 -6.545  49.521  1    49.24  ? 274 GLU D C   1 
ATOM   7790 O  O   . GLU D 2 104 ? -35.057 -7.734  49.618  1    51.96  ? 274 GLU D O   1 
ATOM   7791 C  CB  . GLU D 2 104 ? -35.359 -4.992  51.398  1    57.32  ? 274 GLU D CB  1 
ATOM   7792 C  CG  . GLU D 2 104 ? -36.083 -3.715  51.809  1    67.78  ? 274 GLU D CG  1 
ATOM   7793 C  CD  . GLU D 2 104 ? -35.695 -3.274  53.21   1    91.1   ? 274 GLU D CD  1 
ATOM   7794 O  OE1 . GLU D 2 104 ? -36.127 -2.183  53.658  1    98.38  ? 274 GLU D OE1 1 
ATOM   7795 O  OE2 . GLU D 2 104 ? -34.948 -4.043  53.863  1    99.78  ? 274 GLU D OE2 1 
ATOM   7796 N  N   . VAL D 2 105 ? -33.551 -6.141  49.051  1    43.36  ? 275 VAL D N   1 
ATOM   7797 C  CA  . VAL D 2 105 ? -32.565 -7.113  48.61   1    46.35  ? 275 VAL D CA  1 
ATOM   7798 C  C   . VAL D 2 105 ? -32.267 -8.15   49.704  1    46.9   ? 275 VAL D C   1 
ATOM   7799 O  O   . VAL D 2 105 ? -32.171 -9.357  49.434  1    42.86  ? 275 VAL D O   1 
ATOM   7800 C  CB  . VAL D 2 105 ? -31.305 -6.407  48.064  1    43.83  ? 275 VAL D CB  1 
ATOM   7801 C  CG1 . VAL D 2 105 ? -30.241 -7.414  47.681  1    38.72  ? 275 VAL D CG1 1 
ATOM   7802 C  CG2 . VAL D 2 105 ? -31.656 -5.559  46.837  1    41.17  ? 275 VAL D CG2 1 
ATOM   7803 N  N   . ALA D 2 106 ? -32.126 -7.671  50.95   1    47.22  ? 276 ALA D N   1 
ATOM   7804 C  CA  . ALA D 2 106 ? -31.832 -8.554  52.07   1    50.95  ? 276 ALA D CA  1 
ATOM   7805 C  C   . ALA D 2 106 ? -32.777 -9.77   52.098  1    52.79  ? 276 ALA D C   1 
ATOM   7806 O  O   . ALA D 2 106 ? -32.347 -10.875 52.449  1    50.08  ? 276 ALA D O   1 
ATOM   7807 C  CB  . ALA D 2 106 ? -31.856 -7.772  53.366  1    50     ? 276 ALA D CB  1 
ATOM   7808 N  N   . GLU D 2 107 ? -34.056 -9.542  51.744  1    49.67  ? 277 GLU D N   1 
ATOM   7809 C  CA  . GLU D 2 107 ? -35.093 -10.554 51.79   1    51.79  ? 277 GLU D CA  1 
ATOM   7810 C  C   . GLU D 2 107 ? -34.821 -11.607 50.716  1    52.9   ? 277 GLU D C   1 
ATOM   7811 O  O   . GLU D 2 107 ? -35.029 -12.799 50.957  1    59.79  ? 277 GLU D O   1 
ATOM   7812 C  CB  . GLU D 2 107 ? -36.478 -9.901  51.74   1    55.92  ? 277 GLU D CB  1 
ATOM   7813 C  CG  . GLU D 2 107 ? -36.88  -9.179  53.03   1    66.12  ? 277 GLU D CG  1 
ATOM   7814 C  CD  . GLU D 2 107 ? -38.13  -8.287  52.942  1    86.34  ? 277 GLU D CD  1 
ATOM   7815 O  OE1 . GLU D 2 107 ? -39.21  -8.784  53.358  1    101.01 ? 277 GLU D OE1 1 
ATOM   7816 O  OE2 . GLU D 2 107 ? -38.071 -7.101  52.498  1    87.97  ? 277 GLU D OE2 1 
ATOM   7817 N  N   . PHE D 2 108 ? -34.295 -11.176 49.561  1    49.99  ? 278 PHE D N   1 
ATOM   7818 C  CA  . PHE D 2 108 ? -33.996 -12.084 48.462  1    44.12  ? 278 PHE D CA  1 
ATOM   7819 C  C   . PHE D 2 108 ? -32.784 -12.947 48.803  1    48.72  ? 278 PHE D C   1 
ATOM   7820 O  O   . PHE D 2 108 ? -32.652 -14.077 48.305  1    52.89  ? 278 PHE D O   1 
ATOM   7821 C  CB  . PHE D 2 108 ? -33.769 -11.331 47.151  1    38.37  ? 278 PHE D CB  1 
ATOM   7822 C  CG  . PHE D 2 108 ? -35.073 -10.878 46.521  1    41.77  ? 278 PHE D CG  1 
ATOM   7823 C  CD1 . PHE D 2 108 ? -35.82  -11.77  45.734  1    40.96  ? 278 PHE D CD1 1 
ATOM   7824 C  CD2 . PHE D 2 108 ? -35.589 -9.599  46.767  1    40.56  ? 278 PHE D CD2 1 
ATOM   7825 C  CE1 . PHE D 2 108 ? -37.025 -11.377 45.157  1    41.3   ? 278 PHE D CE1 1 
ATOM   7826 C  CE2 . PHE D 2 108 ? -36.816 -9.225  46.211  1    43.38  ? 278 PHE D CE2 1 
ATOM   7827 C  CZ  . PHE D 2 108 ? -37.528 -10.101 45.385  1    41.29  ? 278 PHE D CZ  1 
ATOM   7828 N  N   . VAL D 2 109 ? -31.889 -12.406 49.627  1    44.97  ? 279 VAL D N   1 
ATOM   7829 C  CA  . VAL D 2 109 ? -30.729 -13.17  50.057  1    51.86  ? 279 VAL D CA  1 
ATOM   7830 C  C   . VAL D 2 109 ? -31.176 -14.192 51.105  1    58.3   ? 279 VAL D C   1 
ATOM   7831 O  O   . VAL D 2 109 ? -30.609 -15.281 51.205  1    63.53  ? 279 VAL D O   1 
ATOM   7832 C  CB  . VAL D 2 109 ? -29.62  -12.265 50.631  1    52.06  ? 279 VAL D CB  1 
ATOM   7833 C  CG1 . VAL D 2 109 ? -28.486 -13.081 51.23   1    50.05  ? 279 VAL D CG1 1 
ATOM   7834 C  CG2 . VAL D 2 109 ? -29.078 -11.295 49.603  1    49.15  ? 279 VAL D CG2 1 
ATOM   7835 N  N   . TYR D 2 110 ? -32.176 -13.813 51.905  1    58.22  ? 280 TYR D N   1 
ATOM   7836 C  CA  . TYR D 2 110 ? -32.625 -14.637 53.011  1    58.58  ? 280 TYR D CA  1 
ATOM   7837 C  C   . TYR D 2 110 ? -33.32  -15.893 52.482  1    55.92  ? 280 TYR D C   1 
ATOM   7838 O  O   . TYR D 2 110 ? -33.134 -16.968 53.033  1    56.01  ? 280 TYR D O   1 
ATOM   7839 C  CB  . TYR D 2 110 ? -33.473 -13.784 53.954  1    59.14  ? 280 TYR D CB  1 
ATOM   7840 C  CG  . TYR D 2 110 ? -34.13  -14.605 55.055  1    78.01  ? 280 TYR D CG  1 
ATOM   7841 C  CD1 . TYR D 2 110 ? -33.481 -14.853 56.264  1    85.07  ? 280 TYR D CD1 1 
ATOM   7842 C  CD2 . TYR D 2 110 ? -35.412 -15.136 54.882  1    86.37  ? 280 TYR D CD2 1 
ATOM   7843 C  CE1 . TYR D 2 110 ? -34.1   -15.578 57.273  1    87.92  ? 280 TYR D CE1 1 
ATOM   7844 C  CE2 . TYR D 2 110 ? -36.025 -15.885 55.872  1    83.16  ? 280 TYR D CE2 1 
ATOM   7845 C  CZ  . TYR D 2 110 ? -35.368 -16.103 57.068  1    85.37  ? 280 TYR D CZ  1 
ATOM   7846 O  OH  . TYR D 2 110 ? -36.015 -16.842 58.012  1    97.62  ? 280 TYR D OH  1 
ATOM   7847 N  N   . ILE D 2 111 ? -34.075 -15.775 51.381  1    58.65  ? 281 ILE D N   1 
ATOM   7848 C  CA  . ILE D 2 111 ? -34.87  -16.897 50.873  1    66.02  ? 281 ILE D CA  1 
ATOM   7849 C  C   . ILE D 2 111 ? -34.014 -17.99  50.212  1    66.04  ? 281 ILE D C   1 
ATOM   7850 O  O   . ILE D 2 111 ? -34.519 -19.095 50.005  1    66.66  ? 281 ILE D O   1 
ATOM   7851 C  CB  . ILE D 2 111 ? -35.956 -16.432 49.888  1    61.13  ? 281 ILE D CB  1 
ATOM   7852 C  CG1 . ILE D 2 111 ? -35.334 -15.565 48.803  1    57.9   ? 281 ILE D CG1 1 
ATOM   7853 C  CG2 . ILE D 2 111 ? -37.102 -15.724 50.608  1    61.89  ? 281 ILE D CG2 1 
ATOM   7854 C  CD1 . ILE D 2 111 ? -36.171 -15.425 47.547  1    60.64  ? 281 ILE D CD1 1 
ATOM   7855 N  N   . THR D 2 112 ? -32.766 -17.66  49.832  1    61.21  ? 282 THR D N   1 
ATOM   7856 C  CA  . THR D 2 112 ? -31.827 -18.613 49.249  1    62.41  ? 282 THR D CA  1 
ATOM   7857 C  C   . THR D 2 112 ? -31.145 -19.425 50.339  1    67.5   ? 282 THR D C   1 
ATOM   7858 O  O   . THR D 2 112 ? -30.292 -20.246 49.995  1    65.68  ? 282 THR D O   1 
ATOM   7859 C  CB  . THR D 2 112 ? -30.741 -17.992 48.364  1    59.77  ? 282 THR D CB  1 
ATOM   7860 O  OG1 . THR D 2 112 ? -29.905 -17.19  49.191  1    59.33  ? 282 THR D OG1 1 
ATOM   7861 C  CG2 . THR D 2 112 ? -31.262 -17.201 47.179  1    53.57  ? 282 THR D CG2 1 
ATOM   7862 N  N   . ASP D 2 113 ? -31.505 -19.173 51.62   1    78.32  ? 283 ASP D N   1 
ATOM   7863 C  CA  . ASP D 2 113 ? -30.912 -19.801 52.805  1    81.12  ? 283 ASP D CA  1 
ATOM   7864 C  C   . ASP D 2 113 ? -29.423 -19.475 52.906  1    78.98  ? 283 ASP D C   1 
ATOM   7865 O  O   . ASP D 2 113 ? -28.62  -20.348 53.244  1    77.33  ? 283 ASP D O   1 
ATOM   7866 C  CB  . ASP D 2 113 ? -31.02  -21.321 52.795  1    91.41  ? 283 ASP D CB  1 
ATOM   7867 C  CG  . ASP D 2 113 ? -32.401 -21.903 53.039  1    102    ? 283 ASP D CG  1 
ATOM   7868 O  OD1 . ASP D 2 113 ? -33.366 -21.439 52.368  1    107.8  ? 283 ASP D OD1 1 
ATOM   7869 O  OD2 . ASP D 2 113 ? -32.476 -22.829 53.879  1    101.49 ? 283 ASP D OD2 1 
ATOM   7870 N  N   . ASP D 2 114 ? -29.063 -18.215 52.616  1    82.26  ? 284 ASP D N   1 
ATOM   7871 C  CA  . ASP D 2 114 ? -27.67  -17.782 52.553  1    90.26  ? 284 ASP D CA  1 
ATOM   7872 C  C   . ASP D 2 114 ? -26.814 -18.719 51.669  1    81.22  ? 284 ASP D C   1 
ATOM   7873 O  O   . ASP D 2 114 ? -25.621 -18.917 51.904  1    74.19  ? 284 ASP D O   1 
ATOM   7874 C  CB  . ASP D 2 114 ? -27.145 -17.501 53.96   1    105.72 ? 284 ASP D CB  1 
ATOM   7875 C  CG  . ASP D 2 114 ? -28.061 -16.72  54.903  1    104.91 ? 284 ASP D CG  1 
ATOM   7876 O  OD1 . ASP D 2 114 ? -28.672 -15.723 54.456  1    103.95 ? 284 ASP D OD1 1 
ATOM   7877 O  OD2 . ASP D 2 114 ? -28.144 -17.102 56.097  1    106.11 ? 284 ASP D OD2 1 
ATOM   7878 N  N   . THR D 2 115 ? -27.411 -19.303 50.622  1    72.47  ? 285 THR D N   1 
ATOM   7879 C  CA  . THR D 2 115 ? -26.642 -20.006 49.605  1    74.16  ? 285 THR D CA  1 
ATOM   7880 C  C   . THR D 2 115 ? -25.701 -18.993 48.934  1    68.88  ? 285 THR D C   1 
ATOM   7881 O  O   . THR D 2 115 ? -24.549 -19.298 48.633  1    71.19  ? 285 THR D O   1 
ATOM   7882 C  CB  . THR D 2 115 ? -27.573 -20.7   48.597  1    75.58  ? 285 THR D CB  1 
ATOM   7883 O  OG1 . THR D 2 115 ? -28.391 -21.674 49.231  1    72.82  ? 285 THR D OG1 1 
ATOM   7884 C  CG2 . THR D 2 115 ? -26.823 -21.477 47.532  1    71.86  ? 285 THR D CG2 1 
ATOM   7885 N  N   . TYR D 2 116 ? -26.207 -17.779 48.699  1    57.29  ? 286 TYR D N   1 
ATOM   7886 C  CA  . TYR D 2 116 ? -25.414 -16.724 48.097  1    56.32  ? 286 TYR D CA  1 
ATOM   7887 C  C   . TYR D 2 116 ? -25.262 -15.556 49.057  1    55.89  ? 286 TYR D C   1 
ATOM   7888 O  O   . TYR D 2 116 ? -25.995 -15.448 50.028  1    60.82  ? 286 TYR D O   1 
ATOM   7889 C  CB  . TYR D 2 116 ? -26.051 -16.272 46.782  1    50.34  ? 286 TYR D CB  1 
ATOM   7890 C  CG  . TYR D 2 116 ? -26.391 -17.441 45.871  1    48.68  ? 286 TYR D CG  1 
ATOM   7891 C  CD1 . TYR D 2 116 ? -25.384 -18.24  45.326  1    45.22  ? 286 TYR D CD1 1 
ATOM   7892 C  CD2 . TYR D 2 116 ? -27.715 -17.76  45.581  1    46.1   ? 286 TYR D CD2 1 
ATOM   7893 C  CE1 . TYR D 2 116 ? -25.693 -19.328 44.527  1    43.9   ? 286 TYR D CE1 1 
ATOM   7894 C  CE2 . TYR D 2 116 ? -28.03  -18.844 44.78   1    42.97  ? 286 TYR D CE2 1 
ATOM   7895 C  CZ  . TYR D 2 116 ? -27.017 -19.617 44.242  1    43.57  ? 286 TYR D CZ  1 
ATOM   7896 O  OH  . TYR D 2 116 ? -27.318 -20.652 43.409  1    47.74  ? 286 TYR D OH  1 
ATOM   7897 N  N   . THR D 2 117 ? -24.281 -14.701 48.761  1    53.93  ? 287 THR D N   1 
ATOM   7898 C  CA  . THR D 2 117 ? -24.089 -13.419 49.427  1    57.59  ? 287 THR D CA  1 
ATOM   7899 C  C   . THR D 2 117 ? -24.949 -12.342 48.761  1    55.07  ? 287 THR D C   1 
ATOM   7900 O  O   . THR D 2 117 ? -25.351 -12.499 47.608  1    48.79  ? 287 THR D O   1 
ATOM   7901 C  CB  . THR D 2 117 ? -22.613 -13.005 49.372  1    60.36  ? 287 THR D CB  1 
ATOM   7902 O  OG1 . THR D 2 117 ? -22.305 -12.84  47.992  1    51.31  ? 287 THR D OG1 1 
ATOM   7903 C  CG2 . THR D 2 117 ? -21.679 -14.026 50.002  1    56.42  ? 287 THR D CG2 1 
ATOM   7904 N  N   . LYS D 2 118 ? -25.153 -11.217 49.471  1    55.3   ? 288 LYS D N   1 
ATOM   7905 C  CA  . LYS D 2 118 ? -25.872 -10.071 48.929  1    54.37  ? 288 LYS D CA  1 
ATOM   7906 C  C   . LYS D 2 118 ? -25.159 -9.535  47.684  1    55.4   ? 288 LYS D C   1 
ATOM   7907 O  O   . LYS D 2 118 ? -25.81  -9.152  46.709  1    50.4   ? 288 LYS D O   1 
ATOM   7908 C  CB  . LYS D 2 118 ? -25.999 -8.99   50.008  1    50.97  ? 288 LYS D CB  1 
ATOM   7909 C  CG  . LYS D 2 118 ? -26.996 -7.868  49.783  1    48.05  ? 288 LYS D CG  1 
ATOM   7910 C  CD  . LYS D 2 118 ? -27.053 -7.114  51.117  1    57.03  ? 288 LYS D CD  1 
ATOM   7911 C  CE  . LYS D 2 118 ? -27.836 -5.841  51.215  1    57.29  ? 288 LYS D CE  1 
ATOM   7912 N  NZ  . LYS D 2 118 ? -27.676 -5.226  52.529  1    59.63  ? 288 LYS D NZ  1 
ATOM   7913 N  N   . LYS D 2 119 ? -23.813 -9.524  47.726  1    55.56  ? 289 LYS D N   1 
ATOM   7914 C  CA  . LYS D 2 119 ? -23.021 -8.978  46.64   1    53.23  ? 289 LYS D CA  1 
ATOM   7915 C  C   . LYS D 2 119 ? -23.221 -9.832  45.388  1    49.55  ? 289 LYS D C   1 
ATOM   7916 O  O   . LYS D 2 119 ? -23.273 -9.305  44.279  1    46.21  ? 289 LYS D O   1 
ATOM   7917 C  CB  . LYS D 2 119 ? -21.551 -8.89   47.055  1    64.59  ? 289 LYS D CB  1 
ATOM   7918 C  CG  . LYS D 2 119 ? -20.729 -7.86   46.288  1    71.25  ? 289 LYS D CG  1 
ATOM   7919 C  CD  . LYS D 2 119 ? -19.26  -7.926  46.702  1    68.81  ? 289 LYS D CD  1 
ATOM   7920 C  CE  . LYS D 2 119 ? -18.671 -6.551  46.538  1    90.42  ? 289 LYS D CE  1 
ATOM   7921 N  NZ  . LYS D 2 119 ? -17.221 -6.489  46.788  1    90.26  ? 289 LYS D NZ  1 
ATOM   7922 N  N   . GLN D 2 120 ? -23.355 -11.152 45.57   1    46.58  ? 290 GLN D N   1 
ATOM   7923 C  CA  . GLN D 2 120 ? -23.61  -12.034 44.445  1    47.88  ? 290 GLN D CA  1 
ATOM   7924 C  C   . GLN D 2 120 ? -24.95  -11.694 43.806  1    46.03  ? 290 GLN D C   1 
ATOM   7925 O  O   . GLN D 2 120 ? -25.051 -11.566 42.575  1    39.48  ? 290 GLN D O   1 
ATOM   7926 C  CB  . GLN D 2 120 ? -23.562 -13.496 44.856  1    49.44  ? 290 GLN D CB  1 
ATOM   7927 C  CG  . GLN D 2 120 ? -22.135 -13.994 45.06   1    52.5   ? 290 GLN D CG  1 
ATOM   7928 C  CD  . GLN D 2 120 ? -22.106 -15.441 45.492  1    55.38  ? 290 GLN D CD  1 
ATOM   7929 O  OE1 . GLN D 2 120 ? -22.692 -15.802 46.519  1    57.72  ? 290 GLN D OE1 1 
ATOM   7930 N  NE2 . GLN D 2 120 ? -21.489 -16.285 44.674  1    51.66  ? 290 GLN D NE2 1 
ATOM   7931 N  N   . VAL D 2 121 ? -25.962 -11.521 44.662  1    40.26  ? 291 VAL D N   1 
ATOM   7932 C  CA  . VAL D 2 121 ? -27.278 -11.177 44.165  1    40.53  ? 291 VAL D CA  1 
ATOM   7933 C  C   . VAL D 2 121 ? -27.244 -9.834  43.422  1    40.84  ? 291 VAL D C   1 
ATOM   7934 O  O   . VAL D 2 121 ? -27.839 -9.702  42.354  1    42.37  ? 291 VAL D O   1 
ATOM   7935 C  CB  . VAL D 2 121 ? -28.319 -11.233 45.298  1    41.67  ? 291 VAL D CB  1 
ATOM   7936 C  CG1 . VAL D 2 121 ? -29.669 -10.702 44.846  1    39.62  ? 291 VAL D CG1 1 
ATOM   7937 C  CG2 . VAL D 2 121 ? -28.449 -12.651 45.844  1    36.15  ? 291 VAL D CG2 1 
ATOM   7938 N  N   . LEU D 2 122 ? -26.523 -8.85   43.936  1    41.73  ? 292 LEU D N   1 
ATOM   7939 C  CA  . LEU D 2 122 ? -26.54  -7.507  43.306  1    45.77  ? 292 LEU D CA  1 
ATOM   7940 C  C   . LEU D 2 122 ? -25.76  -7.518  41.983  1    45.01  ? 292 LEU D C   1 
ATOM   7941 O  O   . LEU D 2 122 ? -26.156 -6.806  41.051  1    42.31  ? 292 LEU D O   1 
ATOM   7942 C  CB  . LEU D 2 122 ? -25.97  -6.515  44.314  1    45.35  ? 292 LEU D CB  1 
ATOM   7943 C  CG  . LEU D 2 122 ? -26.837 -6.264  45.549  1    54.73  ? 292 LEU D CG  1 
ATOM   7944 C  CD1 . LEU D 2 122 ? -26.088 -5.47   46.591  1    53.68  ? 292 LEU D CD1 1 
ATOM   7945 C  CD2 . LEU D 2 122 ? -28.127 -5.573  45.167  1    54.93  ? 292 LEU D CD2 1 
ATOM   7946 N  N   . ARG D 2 123 ? -24.69  -8.3    41.917  1    40.92  ? 293 ARG D N   1 
ATOM   7947 C  CA  . ARG D 2 123 ? -23.87  -8.373  40.689  1    41.13  ? 293 ARG D CA  1 
ATOM   7948 C  C   . ARG D 2 123 ? -24.623 -9.191  39.634  1    36.8   ? 293 ARG D C   1 
ATOM   7949 O  O   . ARG D 2 123 ? -24.555 -8.813  38.462  1    36.97  ? 293 ARG D O   1 
ATOM   7950 C  CB  . ARG D 2 123 ? -22.49  -8.912  41.072  1    47.38  ? 293 ARG D CB  1 
ATOM   7951 C  CG  . ARG D 2 123 ? -21.49  -7.883  41.573  1    49.17  ? 293 ARG D CG  1 
ATOM   7952 C  CD  . ARG D 2 123 ? -20.319 -8.561  42.258  1    72.65  ? 293 ARG D CD  1 
ATOM   7953 N  NE  . ARG D 2 123 ? -19.209 -8.834  41.338  1    107.65 ? 293 ARG D NE  1 
ATOM   7954 C  CZ  . ARG D 2 123 ? -19.05  -9.962  40.655  1    113.87 ? 293 ARG D CZ  1 
ATOM   7955 N  NH1 . ARG D 2 123 ? -19.034 -11.122 41.287  1    92.24  ? 293 ARG D NH1 1 
ATOM   7956 N  NH2 . ARG D 2 123 ? -18.914 -9.924  39.342  1    100.19 ? 293 ARG D NH2 1 
ATOM   7957 N  N   . MET D 2 124 ? -25.315 -10.252 40.043  1    38.18  ? 294 MET D N   1 
ATOM   7958 C  CA  . MET D 2 124 ? -26.149 -11.034 39.097  1    36.27  ? 294 MET D CA  1 
ATOM   7959 C  C   . MET D 2 124 ? -27.257 -10.114 38.601  1    36.65  ? 294 MET D C   1 
ATOM   7960 O  O   . MET D 2 124 ? -27.555 -10.147 37.406  1    40.28  ? 294 MET D O   1 
ATOM   7961 C  CB  . MET D 2 124 ? -26.754 -12.272 39.762  1    34.99  ? 294 MET D CB  1 
ATOM   7962 C  CG  . MET D 2 124 ? -27.508 -13.193 38.826  1    35.96  ? 294 MET D CG  1 
ATOM   7963 S  SD  . MET D 2 124 ? -26.612 -13.687 37.343  1    41.47  ? 294 MET D SD  1 
ATOM   7964 C  CE  . MET D 2 124 ? -25.811 -15.173 37.951  1    42.57  ? 294 MET D CE  1 
ATOM   7965 N  N   . GLU D 2 125 ? -27.835 -9.327  39.5    1    32.28  ? 295 GLU D N   1 
ATOM   7966 C  CA  . GLU D 2 125 ? -28.81  -8.353  39.038  1    35.56  ? 295 GLU D CA  1 
ATOM   7967 C  C   . GLU D 2 125 ? -28.273 -7.542  37.847  1    38.16  ? 295 GLU D C   1 
ATOM   7968 O  O   . GLU D 2 125 ? -28.945 -7.407  36.83   1    38.04  ? 295 GLU D O   1 
ATOM   7969 C  CB  . GLU D 2 125 ? -29.205 -7.377  40.154  1    37.06  ? 295 GLU D CB  1 
ATOM   7970 C  CG  . GLU D 2 125 ? -30.318 -6.412  39.758  1    34.06  ? 295 GLU D CG  1 
ATOM   7971 C  CD  . GLU D 2 125 ? -30.721 -5.364  40.773  1    41.3   ? 295 GLU D CD  1 
ATOM   7972 O  OE1 . GLU D 2 125 ? -29.859 -4.508  41.158  1    44.2   ? 295 GLU D OE1 1 
ATOM   7973 O  OE2 . GLU D 2 125 ? -31.93  -5.387  41.163  1    40.95  ? 295 GLU D OE2 1 
ATOM   7974 N  N   . HIS D 2 126 ? -27.074 -6.971  37.992  1    39.83  ? 296 HIS D N   1 
ATOM   7975 C  CA  . HIS D 2 126 ? -26.512 -6.125  36.954  1    42.99  ? 296 HIS D CA  1 
ATOM   7976 C  C   . HIS D 2 126 ? -26.24  -6.968  35.697  1    44.33  ? 296 HIS D C   1 
ATOM   7977 O  O   . HIS D 2 126 ? -26.503 -6.526  34.576  1    41.07  ? 296 HIS D O   1 
ATOM   7978 C  CB  . HIS D 2 126 ? -25.261 -5.365  37.441  1    43.06  ? 296 HIS D CB  1 
ATOM   7979 C  CG  . HIS D 2 126 ? -24.924 -4.151  36.609  1    51.49  ? 296 HIS D CG  1 
ATOM   7980 N  ND1 . HIS D 2 126 ? -23.957 -3.239  36.982  1    54.87  ? 296 HIS D ND1 1 
ATOM   7981 C  CD2 . HIS D 2 126 ? -25.394 -3.695  35.406  1    50.06  ? 296 HIS D CD2 1 
ATOM   7982 C  CE1 . HIS D 2 126 ? -23.861 -2.282  36.054  1    51.96  ? 296 HIS D CE1 1 
ATOM   7983 N  NE2 . HIS D 2 126 ? -24.728 -2.538  35.096  1    52.71  ? 296 HIS D NE2 1 
ATOM   7984 N  N   . LEU D 2 127 ? -25.721 -8.189  35.88   1    42.66  ? 297 LEU D N   1 
ATOM   7985 C  CA  . LEU D 2 127 ? -25.408 -9.054  34.757  1    44.46  ? 297 LEU D CA  1 
ATOM   7986 C  C   . LEU D 2 127 ? -26.69  -9.359  33.988  1    43.51  ? 297 LEU D C   1 
ATOM   7987 O  O   . LEU D 2 127 ? -26.685 -9.309  32.76   1    45.9   ? 297 LEU D O   1 
ATOM   7988 C  CB  . LEU D 2 127 ? -24.667 -10.329 35.155  1    41.49  ? 297 LEU D CB  1 
ATOM   7989 C  CG  . LEU D 2 127 ? -24.324 -11.259 33.984  1    39.55  ? 297 LEU D CG  1 
ATOM   7990 C  CD1 . LEU D 2 127 ? -23.362 -10.573 33.051  1    36.64  ? 297 LEU D CD1 1 
ATOM   7991 C  CD2 . LEU D 2 127 ? -23.72  -12.563 34.423  1    36.84  ? 297 LEU D CD2 1 
ATOM   7992 N  N   . VAL D 2 128 ? -27.792 -9.592  34.721  1    38.68  ? 298 VAL D N   1 
ATOM   7993 C  CA  . VAL D 2 128 ? -29.049 -9.891  34.052  1    40.64  ? 298 VAL D CA  1 
ATOM   7994 C  C   . VAL D 2 128 ? -29.562 -8.687  33.256  1    43.07  ? 298 VAL D C   1 
ATOM   7995 O  O   . VAL D 2 128 ? -30.039 -8.865  32.131  1    50.45  ? 298 VAL D O   1 
ATOM   7996 C  CB  . VAL D 2 128 ? -30.102 -10.473 34.996  1    36.67  ? 298 VAL D CB  1 
ATOM   7997 C  CG1 . VAL D 2 128 ? -31.458 -10.603 34.308  1    32.77  ? 298 VAL D CG1 1 
ATOM   7998 C  CG2 . VAL D 2 128 ? -29.623 -11.818 35.511  1    32.88  ? 298 VAL D CG2 1 
ATOM   7999 N  N   . LEU D 2 129 ? -29.454 -7.483  33.823  1    42.21  ? 299 LEU D N   1 
ATOM   8000 C  CA  . LEU D 2 129 ? -29.855 -6.269  33.121  1    44.69  ? 299 LEU D CA  1 
ATOM   8001 C  C   . LEU D 2 129 ? -29.057 -6.109  31.82   1    47.87  ? 299 LEU D C   1 
ATOM   8002 O  O   . LEU D 2 129 ? -29.641 -5.789  30.77   1    43.94  ? 299 LEU D O   1 
ATOM   8003 C  CB  . LEU D 2 129 ? -29.747 -5.033  34.009  1    45.63  ? 299 LEU D CB  1 
ATOM   8004 C  CG  . LEU D 2 129 ? -30.877 -4.821  35.027  1    47.85  ? 299 LEU D CG  1 
ATOM   8005 C  CD1 . LEU D 2 129 ? -30.565 -3.658  35.973  1    39.06  ? 299 LEU D CD1 1 
ATOM   8006 C  CD2 . LEU D 2 129 ? -32.21  -4.609  34.307  1    43.24  ? 299 LEU D CD2 1 
ATOM   8007 N  N   . LYS D 2 130 ? -27.741 -6.377  31.882  1    42.27  ? 300 LYS D N   1 
ATOM   8008 C  CA  . LYS D 2 130 ? -26.882 -6.212  30.715  1    45.57  ? 300 LYS D CA  1 
ATOM   8009 C  C   . LYS D 2 130 ? -27.269 -7.238  29.645  1    47.28  ? 300 LYS D C   1 
ATOM   8010 O  O   . LYS D 2 130 ? -27.358 -6.886  28.47   1    42.05  ? 300 LYS D O   1 
ATOM   8011 C  CB  . LYS D 2 130 ? -25.374 -6.289  31.013  1    46.86  ? 300 LYS D CB  1 
ATOM   8012 C  CG  . LYS D 2 130 ? -24.82  -5.301  32.014  1    51.32  ? 300 LYS D CG  1 
ATOM   8013 C  CD  . LYS D 2 130 ? -23.296 -5.306  32.157  1    64.73  ? 300 LYS D CD  1 
ATOM   8014 C  CE  . LYS D 2 130 ? -22.821 -5.338  33.603  1    72.92  ? 300 LYS D CE  1 
ATOM   8015 N  NZ  . LYS D 2 130 ? -21.731 -4.398  33.909  1    74.3   ? 300 LYS D NZ  1 
ATOM   8016 N  N   . VAL D 2 131 ? -27.489 -8.5    30.063  1    46.06  ? 301 VAL D N   1 
ATOM   8017 C  CA  . VAL D 2 131 ? -27.759 -9.583  29.135  1    44.26  ? 301 VAL D CA  1 
ATOM   8018 C  C   . VAL D 2 131 ? -29.099 -9.352  28.439  1    51.34  ? 301 VAL D C   1 
ATOM   8019 O  O   . VAL D 2 131 ? -29.201 -9.58   27.232  1    49.64  ? 301 VAL D O   1 
ATOM   8020 C  CB  . VAL D 2 131 ? -27.678 -10.954 29.823  1    42.15  ? 301 VAL D CB  1 
ATOM   8021 C  CG1 . VAL D 2 131 ? -28.42  -12.047 29.042  1    37.62  ? 301 VAL D CG1 1 
ATOM   8022 C  CG2 . VAL D 2 131 ? -26.225 -11.344 30.087  1    37.66  ? 301 VAL D CG2 1 
ATOM   8023 N  N   . LEU D 2 132 ? -30.1   -8.846  29.183  1    49.68  ? 302 LEU D N   1 
ATOM   8024 C  CA  . LEU D 2 132 ? -31.416 -8.551  28.615  1    44.97  ? 302 LEU D CA  1 
ATOM   8025 C  C   . LEU D 2 132 ? -31.418 -7.161  27.956  1    44.22  ? 302 LEU D C   1 
ATOM   8026 O  O   . LEU D 2 132 ? -32.444 -6.713  27.458  1    41.12  ? 302 LEU D O   1 
ATOM   8027 C  CB  . LEU D 2 132 ? -32.492 -8.617  29.704  1    42.31  ? 302 LEU D CB  1 
ATOM   8028 C  CG  . LEU D 2 132 ? -32.666 -9.962  30.407  1    49.22  ? 302 LEU D CG  1 
ATOM   8029 C  CD1 . LEU D 2 132 ? -33.78  -9.929  31.44   1    48.22  ? 302 LEU D CD1 1 
ATOM   8030 C  CD2 . LEU D 2 132 ? -32.948 -11.058 29.403  1    46.88  ? 302 LEU D CD2 1 
ATOM   8031 N  N   . ALA D 2 133 ? -30.305 -6.425  28.036  1    42.77  ? 303 ALA D N   1 
ATOM   8032 C  CA  . ALA D 2 133 ? -30.261 -5.052  27.54   1    48.55  ? 303 ALA D CA  1 
ATOM   8033 C  C   . ALA D 2 133 ? -31.423 -4.203  28.077  1    48.09  ? 303 ALA D C   1 
ATOM   8034 O  O   . ALA D 2 133 ? -31.945 -3.342  27.362  1    45.29  ? 303 ALA D O   1 
ATOM   8035 C  CB  . ALA D 2 133 ? -30.172 -5.036  26.018  1    43.01  ? 303 ALA D CB  1 
ATOM   8036 N  N   . PHE D 2 134 ? -31.795 -4.417  29.341  1    46.6   ? 304 PHE D N   1 
ATOM   8037 C  CA  . PHE D 2 134 ? -32.852 -3.624  30.033  1    47.44  ? 304 PHE D CA  1 
ATOM   8038 C  C   . PHE D 2 134 ? -34.216 -3.781  29.38   1    44.55  ? 304 PHE D C   1 
ATOM   8039 O  O   . PHE D 2 134 ? -35.082 -2.96   29.648  1    44.66  ? 304 PHE D O   1 
ATOM   8040 C  CB  . PHE D 2 134 ? -32.454 -2.149  30.14   1    47.47  ? 304 PHE D CB  1 
ATOM   8041 C  CG  . PHE D 2 134 ? -31.701 -1.73   31.393  1    51.98  ? 304 PHE D CG  1 
ATOM   8042 C  CD1 . PHE D 2 134 ? -32.386 -1.332  32.534  1    50.15  ? 304 PHE D CD1 1 
ATOM   8043 C  CD2 . PHE D 2 134 ? -30.314 -1.699  31.412  1    50.49  ? 304 PHE D CD2 1 
ATOM   8044 C  CE1 . PHE D 2 134 ? -31.698 -0.934  33.666  1    48.43  ? 304 PHE D CE1 1 
ATOM   8045 C  CE2 . PHE D 2 134 ? -29.633 -1.3    32.548  1    52.2   ? 304 PHE D CE2 1 
ATOM   8046 C  CZ  . PHE D 2 134 ? -30.326 -0.919  33.67   1    47.98  ? 304 PHE D CZ  1 
ATOM   8047 N  N   . ASP D 2 135 ? -34.407 -4.81   28.565  1    50.45  ? 305 ASP D N   1 
ATOM   8048 C  CA  . ASP D 2 135 ? -35.744 -5.063  27.96   1    48.73  ? 305 ASP D CA  1 
ATOM   8049 C  C   . ASP D 2 135 ? -36.558 -5.903  28.94   1    47.15  ? 305 ASP D C   1 
ATOM   8050 O  O   . ASP D 2 135 ? -36.512 -7.131  28.832  1    45.28  ? 305 ASP D O   1 
ATOM   8051 C  CB  . ASP D 2 135 ? -35.625 -5.647  26.566  1    54.85  ? 305 ASP D CB  1 
ATOM   8052 C  CG  . ASP D 2 135 ? -35.506 -4.625  25.451  1    69.29  ? 305 ASP D CG  1 
ATOM   8053 O  OD1 . ASP D 2 135 ? -34.39  -4.109  25.249  1    69.47  ? 305 ASP D OD1 1 
ATOM   8054 O  OD2 . ASP D 2 135 ? -36.535 -4.355  24.803  1    82.61  ? 305 ASP D OD2 1 
ATOM   8055 N  N   . LEU D 2 136 ? -37.286 -5.246  29.842  1    41.26  ? 306 LEU D N   1 
ATOM   8056 C  CA  . LEU D 2 136 ? -38.003 -5.97   30.914  1    37.76  ? 306 LEU D CA  1 
ATOM   8057 C  C   . LEU D 2 136 ? -39.53  -5.912  30.727  1    39.68  ? 306 LEU D C   1 
ATOM   8058 O  O   . LEU D 2 136 ? -40.206 -6.773  31.299  1    41.21  ? 306 LEU D O   1 
ATOM   8059 C  CB  . LEU D 2 136 ? -37.56  -5.348  32.234  1    40.28  ? 306 LEU D CB  1 
ATOM   8060 C  CG  . LEU D 2 136 ? -36.109 -5.572  32.672  1    44.48  ? 306 LEU D CG  1 
ATOM   8061 C  CD1 . LEU D 2 136 ? -36.054 -5.541  34.184  1    51.68  ? 306 LEU D CD1 1 
ATOM   8062 C  CD2 . LEU D 2 136 ? -35.523 -6.869  32.167  1    36.45  ? 306 LEU D CD2 1 
ATOM   8063 N  N   . ALA D 2 137 ? -40.058 -4.949  29.973  1    37.94  ? 307 ALA D N   1 
ATOM   8064 C  CA  . ALA D 2 137 ? -41.507 -4.888  29.828  1    38.71  ? 307 ALA D CA  1 
ATOM   8065 C  C   . ALA D 2 137 ? -41.99  -5.979  28.865  1    41.12  ? 307 ALA D C   1 
ATOM   8066 O  O   . ALA D 2 137 ? -42.422 -5.674  27.753  1    40.77  ? 307 ALA D O   1 
ATOM   8067 C  CB  . ALA D 2 137 ? -41.905 -3.491  29.386  1    35.79  ? 307 ALA D CB  1 
ATOM   8068 N  N   . ALA D 2 138 ? -41.933 -7.243  29.302  1    40.02  ? 308 ALA D N   1 
ATOM   8069 C  CA  . ALA D 2 138 ? -42.24  -8.4    28.461  1    43.15  ? 308 ALA D CA  1 
ATOM   8070 C  C   . ALA D 2 138 ? -43.71  -8.716  28.555  1    43.76  ? 308 ALA D C   1 
ATOM   8071 O  O   . ALA D 2 138 ? -44.252 -8.774  29.646  1    54.81  ? 308 ALA D O   1 
ATOM   8072 C  CB  . ALA D 2 138 ? -41.481 -9.658  28.891  1    39.41  ? 308 ALA D CB  1 
ATOM   8073 N  N   . PRO D 2 139 ? -44.395 -8.996  27.438  1    45.22  ? 309 PRO D N   1 
ATOM   8074 C  CA  . PRO D 2 139 ? -45.792 -9.416  27.533  1    47.67  ? 309 PRO D CA  1 
ATOM   8075 C  C   . PRO D 2 139 ? -45.791 -10.806 28.168  1    46.83  ? 309 PRO D C   1 
ATOM   8076 O  O   . PRO D 2 139 ? -44.923 -11.635 27.864  1    45.52  ? 309 PRO D O   1 
ATOM   8077 C  CB  . PRO D 2 139 ? -46.291 -9.397  26.075  1    46.32  ? 309 PRO D CB  1 
ATOM   8078 C  CG  . PRO D 2 139 ? -45.21  -8.659  25.296  1    46.53  ? 309 PRO D CG  1 
ATOM   8079 C  CD  . PRO D 2 139 ? -43.906 -8.896  26.057  1    45.11  ? 309 PRO D CD  1 
ATOM   8080 N  N   . THR D 2 140 ? -46.76  -11.02  29.068  1    45.89  ? 310 THR D N   1 
ATOM   8081 C  CA  . THR D 2 140 ? -46.93  -12.264 29.814  1    46.6   ? 310 THR D CA  1 
ATOM   8082 C  C   . THR D 2 140 ? -48.244 -12.939 29.42   1    48.42  ? 310 THR D C   1 
ATOM   8083 O  O   . THR D 2 140 ? -49.145 -12.317 28.851  1    49.64  ? 310 THR D O   1 
ATOM   8084 C  CB  . THR D 2 140 ? -46.959 -11.973 31.319  1    45.03  ? 310 THR D CB  1 
ATOM   8085 O  OG1 . THR D 2 140 ? -48.065 -11.1   31.578  1    44.78  ? 310 THR D OG1 1 
ATOM   8086 C  CG2 . THR D 2 140 ? -45.667 -11.362 31.829  1    44.72  ? 310 THR D CG2 1 
ATOM   8087 N  N   . ILE D 2 141 ? -48.374 -14.207 29.802  1    47.71  ? 311 ILE D N   1 
ATOM   8088 C  CA  . ILE D 2 141 ? -49.651 -14.894 29.718  1    49.17  ? 311 ILE D CA  1 
ATOM   8089 C  C   . ILE D 2 141 ? -50.74  -14.047 30.375  1    53.48  ? 311 ILE D C   1 
ATOM   8090 O  O   . ILE D 2 141 ? -51.801 -13.843 29.788  1    59.17  ? 311 ILE D O   1 
ATOM   8091 C  CB  . ILE D 2 141 ? -49.531 -16.273 30.37   1    44.79  ? 311 ILE D CB  1 
ATOM   8092 C  CG1 . ILE D 2 141 ? -48.629 -17.171 29.554  1    44.77  ? 311 ILE D CG1 1 
ATOM   8093 C  CG2 . ILE D 2 141 ? -50.906 -16.882 30.61   1    42.73  ? 311 ILE D CG2 1 
ATOM   8094 C  CD1 . ILE D 2 141 ? -48.168 -18.397 30.333  1    44.03  ? 311 ILE D CD1 1 
ATOM   8095 N  N   . ASN D 2 142 ? -50.466 -13.54  31.581  1    54.79  ? 312 ASN D N   1 
ATOM   8096 C  CA  . ASN D 2 142 ? -51.424 -12.76  32.354  1    51.48  ? 312 ASN D CA  1 
ATOM   8097 C  C   . ASN D 2 142 ? -51.886 -11.513 31.612  1    51.86  ? 312 ASN D C   1 
ATOM   8098 O  O   . ASN D 2 142 ? -53.067 -11.203 31.657  1    58.18  ? 312 ASN D O   1 
ATOM   8099 C  CB  . ASN D 2 142 ? -50.916 -12.431 33.748  1    53.21  ? 312 ASN D CB  1 
ATOM   8100 C  CG  . ASN D 2 142 ? -51.048 -13.635 34.653  1    64.49  ? 312 ASN D CG  1 
ATOM   8101 O  OD1 . ASN D 2 142 ? -50.896 -14.789 34.203  1    65.99  ? 312 ASN D OD1 1 
ATOM   8102 N  ND2 . ASN D 2 142 ? -51.353 -13.376 35.918  1    61.47  ? 312 ASN D ND2 1 
ATOM   8103 N  N   . GLN D 2 143 ? -50.977 -10.792 30.946  1    54.17  ? 313 GLN D N   1 
ATOM   8104 C  CA  . GLN D 2 143 ? -51.365 -9.588  30.218  1    51.03  ? 313 GLN D CA  1 
ATOM   8105 C  C   . GLN D 2 143 ? -52.369 -9.905  29.113  1    51.65  ? 313 GLN D C   1 
ATOM   8106 O  O   . GLN D 2 143 ? -53.164 -9.039  28.772  1    58.83  ? 313 GLN D O   1 
ATOM   8107 C  CB  . GLN D 2 143 ? -50.165 -8.881  29.601  1    45.5   ? 313 GLN D CB  1 
ATOM   8108 C  CG  . GLN D 2 143 ? -49.38  -8.113  30.645  1    48.95  ? 313 GLN D CG  1 
ATOM   8109 C  CD  . GLN D 2 143 ? -48.127 -7.492  30.073  1    49.61  ? 313 GLN D CD  1 
ATOM   8110 O  OE1 . GLN D 2 143 ? -48.171 -6.664  29.152  1    49.54  ? 313 GLN D OE1 1 
ATOM   8111 N  NE2 . GLN D 2 143 ? -46.997 -7.91   30.626  1    44.76  ? 313 GLN D NE2 1 
ATOM   8112 N  N   . PHE D 2 144 ? -52.299 -11.115 28.535  1    48.12  ? 314 PHE D N   1 
ATOM   8113 C  CA  . PHE D 2 144 ? -53.249 -11.528 27.508  1    47.56  ? 314 PHE D CA  1 
ATOM   8114 C  C   . PHE D 2 144 ? -54.536 -12.046 28.153  1    50.04  ? 314 PHE D C   1 
ATOM   8115 O  O   . PHE D 2 144 ? -55.624 -11.678 27.704  1    51.37  ? 314 PHE D O   1 
ATOM   8116 C  CB  . PHE D 2 144 ? -52.669 -12.517 26.504  1    44.12  ? 314 PHE D CB  1 
ATOM   8117 C  CG  . PHE D 2 144 ? -51.662 -11.927 25.544  1    44.74  ? 314 PHE D CG  1 
ATOM   8118 C  CD1 . PHE D 2 144 ? -52.086 -11.173 24.447  1    47.13  ? 314 PHE D CD1 1 
ATOM   8119 C  CD2 . PHE D 2 144 ? -50.295 -12.135 25.74   1    41.66  ? 314 PHE D CD2 1 
ATOM   8120 C  CE1 . PHE D 2 144 ? -51.153 -10.64  23.56   1    47.17  ? 314 PHE D CE1 1 
ATOM   8121 C  CE2 . PHE D 2 144 ? -49.365 -11.591 24.864  1    41.89  ? 314 PHE D CE2 1 
ATOM   8122 C  CZ  . PHE D 2 144 ? -49.79  -10.853 23.772  1    46.81  ? 314 PHE D CZ  1 
ATOM   8123 N  N   . LEU D 2 145 ? -54.411 -12.878 29.203  1    52.73  ? 315 LEU D N   1 
ATOM   8124 C  CA  . LEU D 2 145 ? -55.561 -13.399 29.939  1    57.99  ? 315 LEU D CA  1 
ATOM   8125 C  C   . LEU D 2 145 ? -56.523 -12.268 30.316  1    60.42  ? 315 LEU D C   1 
ATOM   8126 O  O   . LEU D 2 145 ? -57.696 -12.308 29.916  1    60.94  ? 315 LEU D O   1 
ATOM   8127 C  CB  . LEU D 2 145 ? -55.151 -14.196 31.177  1    56.42  ? 315 LEU D CB  1 
ATOM   8128 C  CG  . LEU D 2 145 ? -54.716 -15.648 30.96   1    54.83  ? 315 LEU D CG  1 
ATOM   8129 C  CD1 . LEU D 2 145 ? -54.477 -16.32  32.311  1    49.73  ? 315 LEU D CD1 1 
ATOM   8130 C  CD2 . LEU D 2 145 ? -55.726 -16.425 30.135  1    54.83  ? 315 LEU D CD2 1 
ATOM   8131 N  N   . THR D 2 146 ? -56.005 -11.251 31.036  1    53.16  ? 316 THR D N   1 
ATOM   8132 C  CA  . THR D 2 146 ? -56.84  -10.186 31.586  1    57.74  ? 316 THR D CA  1 
ATOM   8133 C  C   . THR D 2 146 ? -57.632 -9.508  30.465  1    62.41  ? 316 THR D C   1 
ATOM   8134 O  O   . THR D 2 146 ? -58.778 -9.114  30.684  1    73.81  ? 316 THR D O   1 
ATOM   8135 C  CB  . THR D 2 146 ? -56.053 -9.188  32.451  1    54.33  ? 316 THR D CB  1 
ATOM   8136 O  OG1 . THR D 2 146 ? -55.126 -8.503  31.618  1    58.75  ? 316 THR D OG1 1 
ATOM   8137 C  CG2 . THR D 2 146 ? -55.236 -9.827  33.567  1    47.92  ? 316 THR D CG2 1 
ATOM   8138 N  N   . GLN D 2 147 ? -57.035 -9.39   29.266  1    61.78  ? 317 GLN D N   1 
ATOM   8139 C  CA  . GLN D 2 147 ? -57.674 -8.813  28.081  1    59.55  ? 317 GLN D CA  1 
ATOM   8140 C  C   . GLN D 2 147 ? -58.733 -9.742  27.479  1    64.48  ? 317 GLN D C   1 
ATOM   8141 O  O   . GLN D 2 147 ? -59.73  -9.276  26.912  1    66.16  ? 317 GLN D O   1 
ATOM   8142 C  CB  . GLN D 2 147 ? -56.662 -8.534  26.97   1    59.92  ? 317 GLN D CB  1 
ATOM   8143 C  CG  . GLN D 2 147 ? -55.94  -7.202  27.117  1    61.76  ? 317 GLN D CG  1 
ATOM   8144 C  CD  . GLN D 2 147 ? -54.988 -6.858  25.998  1    62.86  ? 317 GLN D CD  1 
ATOM   8145 O  OE1 . GLN D 2 147 ? -53.894 -6.348  26.249  1    78.98  ? 317 GLN D OE1 1 
ATOM   8146 N  NE2 . GLN D 2 147 ? -55.416 -7.015  24.759  1    62.41  ? 317 GLN D NE2 1 
ATOM   8147 N  N   . TYR D 2 148 ? -58.475 -11.057 27.548  1    67.06  ? 318 TYR D N   1 
ATOM   8148 C  CA  . TYR D 2 148 ? -59.411 -12.078 27.093  1    64.72  ? 318 TYR D CA  1 
ATOM   8149 C  C   . TYR D 2 148 ? -60.631 -12.149 28.022  1    63.79  ? 318 TYR D C   1 
ATOM   8150 O  O   . TYR D 2 148 ? -61.74  -12.444 27.559  1    61.89  ? 318 TYR D O   1 
ATOM   8151 C  CB  . TYR D 2 148 ? -58.706 -13.437 27.027  1    60.24  ? 318 TYR D CB  1 
ATOM   8152 C  CG  . TYR D 2 148 ? -57.579 -13.609 26.019  1    58.06  ? 318 TYR D CG  1 
ATOM   8153 C  CD1 . TYR D 2 148 ? -57.364 -12.702 24.975  1    56.63  ? 318 TYR D CD1 1 
ATOM   8154 C  CD2 . TYR D 2 148 ? -56.746 -14.722 26.096  1    54.82  ? 318 TYR D CD2 1 
ATOM   8155 C  CE1 . TYR D 2 148 ? -56.337 -12.892 24.057  1    55.09  ? 318 TYR D CE1 1 
ATOM   8156 C  CE2 . TYR D 2 148 ? -55.715 -14.916 25.191  1    54.43  ? 318 TYR D CE2 1 
ATOM   8157 C  CZ  . TYR D 2 148 ? -55.509 -14.003 24.173  1    56.21  ? 318 TYR D CZ  1 
ATOM   8158 O  OH  . TYR D 2 148 ? -54.483 -14.248 23.301  1    63.31  ? 318 TYR D OH  1 
ATOM   8159 N  N   . PHE D 2 149 ? -60.414 -11.899 29.326  1    61.21  ? 319 PHE D N   1 
ATOM   8160 C  CA  . PHE D 2 149 ? -61.472 -11.96  30.319  1    65.89  ? 319 PHE D CA  1 
ATOM   8161 C  C   . PHE D 2 149 ? -62.59  -10.979 29.981  1    71.2   ? 319 PHE D C   1 
ATOM   8162 O  O   . PHE D 2 149 ? -63.744 -11.24  30.321  1    79.21  ? 319 PHE D O   1 
ATOM   8163 C  CB  . PHE D 2 149 ? -60.958 -11.693 31.731  1    63.22  ? 319 PHE D CB  1 
ATOM   8164 C  CG  . PHE D 2 149 ? -60.065 -12.779 32.302  1    63.79  ? 319 PHE D CG  1 
ATOM   8165 C  CD1 . PHE D 2 149 ? -59.907 -13.99  31.629  1    66.86  ? 319 PHE D CD1 1 
ATOM   8166 C  CD2 . PHE D 2 149 ? -59.422 -12.595 33.525  1    61.96  ? 319 PHE D CD2 1 
ATOM   8167 C  CE1 . PHE D 2 149 ? -59.089 -14.981 32.161  1    75.81  ? 319 PHE D CE1 1 
ATOM   8168 C  CE2 . PHE D 2 149 ? -58.601 -13.58  34.057  1    66.7   ? 319 PHE D CE2 1 
ATOM   8169 C  CZ  . PHE D 2 149 ? -58.429 -14.771 33.372  1    75.65  ? 319 PHE D CZ  1 
ATOM   8170 N  N   . LEU D 2 150 ? -62.243 -9.867  29.321  1    71.26  ? 320 LEU D N   1 
ATOM   8171 C  CA  . LEU D 2 150 ? -63.185 -8.792  29.007  1    75.78  ? 320 LEU D CA  1 
ATOM   8172 C  C   . LEU D 2 150 ? -64.256 -9.239  27.999  1    74.93  ? 320 LEU D C   1 
ATOM   8173 O  O   . LEU D 2 150 ? -65.227 -8.519  27.764  1    79.5   ? 320 LEU D O   1 
ATOM   8174 C  CB  . LEU D 2 150 ? -62.427 -7.559  28.496  1    71.56  ? 320 LEU D CB  1 
ATOM   8175 C  CG  . LEU D 2 150 ? -61.437 -6.879  29.449  1    67.8   ? 320 LEU D CG  1 
ATOM   8176 C  CD1 . LEU D 2 150 ? -60.802 -5.666  28.772  1    61.5   ? 320 LEU D CD1 1 
ATOM   8177 C  CD2 . LEU D 2 150 ? -62.08  -6.488  30.783  1    67.9   ? 320 LEU D CD2 1 
ATOM   8178 N  N   . HIS D 2 151 ? -64.064 -10.397 27.365  1    72.1   ? 321 HIS D N   1 
ATOM   8179 C  CA  . HIS D 2 151 ? -65.035 -10.907 26.415  1    73.81  ? 321 HIS D CA  1 
ATOM   8180 C  C   . HIS D 2 151 ? -66.074 -11.812 27.087  1    77.17  ? 321 HIS D C   1 
ATOM   8181 O  O   . HIS D 2 151 ? -67.12  -12.08  26.479  1    78.56  ? 321 HIS D O   1 
ATOM   8182 C  CB  . HIS D 2 151 ? -64.329 -11.521 25.208  1    75.36  ? 321 HIS D CB  1 
ATOM   8183 C  CG  . HIS D 2 151 ? -63.637 -10.514 24.362  1    78.5   ? 321 HIS D CG  1 
ATOM   8184 N  ND1 . HIS D 2 151 ? -63.809 -10.463 22.989  1    80.18  ? 321 HIS D ND1 1 
ATOM   8185 C  CD2 . HIS D 2 151 ? -62.793 -9.518  24.692  1    75.19  ? 321 HIS D CD2 1 
ATOM   8186 C  CE1 . HIS D 2 151 ? -63.078 -9.467  22.502  1    79.98  ? 321 HIS D CE1 1 
ATOM   8187 N  NE2 . HIS D 2 151 ? -62.451 -8.878  23.522  1    79.92  ? 321 HIS D NE2 1 
ATOM   8188 N  N   . GLN D 2 152 ? -65.797 -12.248 28.332  1    75.52  ? 322 GLN D N   1 
ATOM   8189 C  CA  . GLN D 2 152 ? -66.764 -12.992 29.123  1    80.35  ? 322 GLN D CA  1 
ATOM   8190 C  C   . GLN D 2 152 ? -68.04  -12.169 29.213  1    89.29  ? 322 GLN D C   1 
ATOM   8191 O  O   . GLN D 2 152 ? -67.972 -10.954 29.066  1    92.83  ? 322 GLN D O   1 
ATOM   8192 C  CB  . GLN D 2 152 ? -66.319 -13.223 30.559  1    77.41  ? 322 GLN D CB  1 
ATOM   8193 C  CG  . GLN D 2 152 ? -65.22  -14.257 30.742  1    80.56  ? 322 GLN D CG  1 
ATOM   8194 C  CD  . GLN D 2 152 ? -64.803 -14.319 32.195  1    89.26  ? 322 GLN D CD  1 
ATOM   8195 O  OE1 . GLN D 2 152 ? -65.185 -15.24  32.925  1    95.4   ? 322 GLN D OE1 1 
ATOM   8196 N  NE2 . GLN D 2 152 ? -64.061 -13.31  32.646  1    83.79  ? 322 GLN D NE2 1 
ATOM   8197 N  N   . GLN D 2 153 ? -69.171 -12.844 29.485  1    101.78 ? 323 GLN D N   1 
ATOM   8198 C  CA  . GLN D 2 153 ? -70.503 -12.251 29.417  1    102.54 ? 323 GLN D CA  1 
ATOM   8199 C  C   . GLN D 2 153 ? -71.483 -13.139 30.189  1    97.16  ? 323 GLN D C   1 
ATOM   8200 O  O   . GLN D 2 153 ? -72.154 -13.995 29.606  1    90.85  ? 323 GLN D O   1 
ATOM   8201 C  CB  . GLN D 2 153 ? -70.939 -11.937 27.984  1    109.31 ? 323 GLN D CB  1 
ATOM   8202 C  CG  . GLN D 2 153 ? -72.063 -10.907 27.952  1    128.03 ? 323 GLN D CG  1 
ATOM   8203 C  CD  . GLN D 2 153 ? -72.353 -10.313 26.589  1    135.85 ? 323 GLN D CD  1 
ATOM   8204 O  OE1 . GLN D 2 153 ? -71.698 -10.631 25.586  1    126.93 ? 323 GLN D OE1 1 
ATOM   8205 N  NE2 . GLN D 2 153 ? -73.358 -9.445  26.546  1    141.75 ? 323 GLN D NE2 1 
ATOM   8206 N  N   . PRO D 2 154 ? -71.553 -12.991 31.536  1    95.21  ? 324 PRO D N   1 
ATOM   8207 C  CA  . PRO D 2 154 ? -70.774 -11.969 32.242  1    90.89  ? 324 PRO D CA  1 
ATOM   8208 C  C   . PRO D 2 154 ? -69.416 -12.548 32.652  1    93.71  ? 324 PRO D C   1 
ATOM   8209 O  O   . PRO D 2 154 ? -69.043 -13.644 32.222  1    92.6   ? 324 PRO D O   1 
ATOM   8210 C  CB  . PRO D 2 154 ? -71.669 -11.732 33.456  1    91.71  ? 324 PRO D CB  1 
ATOM   8211 C  CG  . PRO D 2 154 ? -72.193 -13.132 33.791  1    95.08  ? 324 PRO D CG  1 
ATOM   8212 C  CD  . PRO D 2 154 ? -72.337 -13.845 32.452  1    94.86  ? 324 PRO D CD  1 
ATOM   8213 N  N   . ALA D 2 155 ? -68.737 -11.873 33.572  1    88.36  ? 325 ALA D N   1 
ATOM   8214 C  CA  . ALA D 2 155 ? -67.452 -12.395 34.073  1    80.5   ? 325 ALA D CA  1 
ATOM   8215 C  C   . ALA D 2 155 ? -67.708 -13.542 35.039  1    85.82  ? 325 ALA D C   1 
ATOM   8216 O  O   . ALA D 2 155 ? -68.674 -13.443 35.812  1    89.89  ? 325 ALA D O   1 
ATOM   8217 C  CB  . ALA D 2 155 ? -66.723 -11.291 34.767  1    74.59  ? 325 ALA D CB  1 
ATOM   8218 N  N   . ASN D 2 156 ? -66.863 -14.575 35.009  1    86.97  ? 326 ASN D N   1 
ATOM   8219 C  CA  . ASN D 2 156 ? -66.985 -15.669 36.008  1    84.94  ? 326 ASN D CA  1 
ATOM   8220 C  C   . ASN D 2 156 ? -65.681 -15.792 36.794  1    85.44  ? 326 ASN D C   1 
ATOM   8221 O  O   . ASN D 2 156 ? -64.635 -16.027 36.168  1    80.14  ? 326 ASN D O   1 
ATOM   8222 C  CB  . ASN D 2 156 ? -67.352 -17.003 35.377  1    92.16  ? 326 ASN D CB  1 
ATOM   8223 C  CG  . ASN D 2 156 ? -67.443 -18.097 36.411  1    98.55  ? 326 ASN D CG  1 
ATOM   8224 O  OD1 . ASN D 2 156 ? -66.562 -18.958 36.484  1    96.04  ? 326 ASN D OD1 1 
ATOM   8225 N  ND2 . ASN D 2 156 ? -68.486 -18.076 37.225  1    97.1   ? 326 ASN D ND2 1 
ATOM   8226 N  N   . CYS D 2 157 ? -65.758 -15.656 38.113  1    88.03  ? 327 CYS D N   1 
ATOM   8227 C  CA  . CYS D 2 157 ? -64.574 -15.788 38.991  1    82.65  ? 327 CYS D CA  1 
ATOM   8228 C  C   . CYS D 2 157 ? -63.846 -17.104 38.729  1    81.41  ? 327 CYS D C   1 
ATOM   8229 O  O   . CYS D 2 157 ? -62.617 -17.078 38.597  1    80.15  ? 327 CYS D O   1 
ATOM   8230 C  CB  . CYS D 2 157 ? -65.013 -15.871 40.442  1    91.04  ? 327 CYS D CB  1 
ATOM   8231 S  SG  . CYS D 2 157 ? -66.4   -14.782 40.843  1    128.18 ? 327 CYS D SG  1 
ATOM   8232 N  N   . LYS D 2 158 ? -64.581 -18.209 38.678  1    85.89  ? 328 LYS D N   1 
ATOM   8233 C  CA  . LYS D 2 158 ? -63.929 -19.532 38.53   1    84.24  ? 328 LYS D CA  1 
ATOM   8234 C  C   . LYS D 2 158 ? -63.269 -19.62  37.153  1    80.92  ? 328 LYS D C   1 
ATOM   8235 O  O   . LYS D 2 158 ? -62.156 -20.155 37.074  1    86.09  ? 328 LYS D O   1 
ATOM   8236 C  CB  . LYS D 2 158 ? -64.956 -20.64  38.769  1    92.86  ? 328 LYS D CB  1 
ATOM   8237 C  CG  . LYS D 2 158 ? -65.472 -20.719 40.194  1    101.42 ? 328 LYS D CG  1 
ATOM   8238 C  CD  . LYS D 2 158 ? -66.508 -21.817 40.383  1    102.51 ? 328 LYS D CD  1 
ATOM   8239 C  CE  . LYS D 2 158 ? -66.99  -21.9   41.795  1    104.12 ? 328 LYS D CE  1 
ATOM   8240 N  NZ  . LYS D 2 158 ? -68.003 -22.945 41.958  1    104.8  ? 328 LYS D NZ  1 
ATOM   8241 N  N   . VAL D 2 159 ? -63.917 -19.095 36.121  1    78.18  ? 329 VAL D N   1 
ATOM   8242 C  CA  . VAL D 2 159 ? -63.258 -19.102 34.821  1    75.43  ? 329 VAL D CA  1 
ATOM   8243 C  C   . VAL D 2 159 ? -61.944 -18.313 34.891  1    75.43  ? 329 VAL D C   1 
ATOM   8244 O  O   . VAL D 2 159 ? -60.958 -18.697 34.263  1    70.89  ? 329 VAL D O   1 
ATOM   8245 C  CB  . VAL D 2 159 ? -64.187 -18.571 33.709  1    72.5   ? 329 VAL D CB  1 
ATOM   8246 C  CG1 . VAL D 2 159 ? -63.464 -18.392 32.384  1    67.89  ? 329 VAL D CG1 1 
ATOM   8247 C  CG2 . VAL D 2 159 ? -65.396 -19.464 33.504  1    76.7   ? 329 VAL D CG2 1 
ATOM   8248 N  N   . GLU D 2 160 ? -61.921 -17.214 35.661  1    79.5   ? 330 GLU D N   1 
ATOM   8249 C  CA  . GLU D 2 160 ? -60.753 -16.334 35.72   1    76.78  ? 330 GLU D CA  1 
ATOM   8250 C  C   . GLU D 2 160 ? -59.641 -16.999 36.516  1    68.65  ? 330 GLU D C   1 
ATOM   8251 O  O   . GLU D 2 160 ? -58.516 -17.083 36.024  1    69.32  ? 330 GLU D O   1 
ATOM   8252 C  CB  . GLU D 2 160 ? -61.082 -14.947 36.271  1    79.21  ? 330 GLU D CB  1 
ATOM   8253 C  CG  . GLU D 2 160 ? -61.956 -14.148 35.304  1    87.9   ? 330 GLU D CG  1 
ATOM   8254 C  CD  . GLU D 2 160 ? -62.208 -12.712 35.686  1    85.75  ? 330 GLU D CD  1 
ATOM   8255 O  OE1 . GLU D 2 160 ? -61.732 -12.325 36.76   1    86.4   ? 330 GLU D OE1 1 
ATOM   8256 O  OE2 . GLU D 2 160 ? -62.866 -12.011 34.898  1    87.54  ? 330 GLU D OE2 1 
ATOM   8257 N  N   . SER D 2 161 ? -59.991 -17.497 37.708  1    63.86  ? 331 SER D N   1 
ATOM   8258 C  CA  . SER D 2 161 ? -59.06  -18.192 38.577  1    64.05  ? 331 SER D CA  1 
ATOM   8259 C  C   . SER D 2 161 ? -58.458 -19.416 37.89   1    66.66  ? 331 SER D C   1 
ATOM   8260 O  O   . SER D 2 161 ? -57.258 -19.65  38      1    70.96  ? 331 SER D O   1 
ATOM   8261 C  CB  . SER D 2 161 ? -59.677 -18.544 39.903  1    67.08  ? 331 SER D CB  1 
ATOM   8262 O  OG  . SER D 2 161 ? -59.68  -17.418 40.771  1    72.72  ? 331 SER D OG  1 
ATOM   8263 N  N   . LEU D 2 162 ? -59.285 -20.195 37.19   1    70.14  ? 332 LEU D N   1 
ATOM   8264 C  CA  . LEU D 2 162 ? -58.828 -21.447 36.605  1    72.19  ? 332 LEU D CA  1 
ATOM   8265 C  C   . LEU D 2 162 ? -57.89  -21.175 35.429  1    69.15  ? 332 LEU D C   1 
ATOM   8266 O  O   . LEU D 2 162 ? -56.916 -21.909 35.239  1    69.92  ? 332 LEU D O   1 
ATOM   8267 C  CB  . LEU D 2 162 ? -60.013 -22.327 36.206  1    71.04  ? 332 LEU D CB  1 
ATOM   8268 C  CG  . LEU D 2 162 ? -59.661 -23.703 35.616  1    77.89  ? 332 LEU D CG  1 
ATOM   8269 C  CD1 . LEU D 2 162 ? -58.813 -24.547 36.569  1    83.26  ? 332 LEU D CD1 1 
ATOM   8270 C  CD2 . LEU D 2 162 ? -60.864 -24.527 35.169  1    81.16  ? 332 LEU D CD2 1 
ATOM   8271 N  N   . ALA D 2 163 ? -58.199 -20.145 34.627  1    65.03  ? 333 ALA D N   1 
ATOM   8272 C  CA  . ALA D 2 163 ? -57.326 -19.791 33.517  1    66.66  ? 333 ALA D CA  1 
ATOM   8273 C  C   . ALA D 2 163 ? -55.944 -19.351 34.03   1    67.5   ? 333 ALA D C   1 
ATOM   8274 O  O   . ALA D 2 163 ? -54.917 -19.722 33.444  1    66.85  ? 333 ALA D O   1 
ATOM   8275 C  CB  . ALA D 2 163 ? -57.991 -18.766 32.621  1    65.59  ? 333 ALA D CB  1 
ATOM   8276 N  N   . MET D 2 164 ? -55.914 -18.592 35.144  1    67.45  ? 334 MET D N   1 
ATOM   8277 C  CA  . MET D 2 164 ? -54.668 -18.154 35.772  1    65.41  ? 334 MET D CA  1 
ATOM   8278 C  C   . MET D 2 164 ? -53.859 -19.371 36.23   1    66.72  ? 334 MET D C   1 
ATOM   8279 O  O   . MET D 2 164 ? -52.635 -19.412 36.031  1    63.91  ? 334 MET D O   1 
ATOM   8280 C  CB  . MET D 2 164 ? -54.912 -17.216 36.965  1    65.14  ? 334 MET D CB  1 
ATOM   8281 C  CG  . MET D 2 164 ? -55.371 -15.795 36.626  1    69.78  ? 334 MET D CG  1 
ATOM   8282 S  SD  . MET D 2 164 ? -54.22  -14.751 35.691  1    74.4   ? 334 MET D SD  1 
ATOM   8283 C  CE  . MET D 2 164 ? -55.005 -13.141 35.866  1    88.28  ? 334 MET D CE  1 
ATOM   8284 N  N   . PHE D 2 165 ? -54.561 -20.351 36.835  1    63.39  ? 335 PHE D N   1 
ATOM   8285 C  CA  . PHE D 2 165 ? -53.967 -21.571 37.368  1    61.48  ? 335 PHE D CA  1 
ATOM   8286 C  C   . PHE D 2 165 ? -53.292 -22.378 36.261  1    60.86  ? 335 PHE D C   1 
ATOM   8287 O  O   . PHE D 2 165 ? -52.138 -22.782 36.395  1    59.04  ? 335 PHE D O   1 
ATOM   8288 C  CB  . PHE D 2 165 ? -55.041 -22.424 38.044  1    62.28  ? 335 PHE D CB  1 
ATOM   8289 C  CG  . PHE D 2 165 ? -54.621 -23.853 38.344  1    62.92  ? 335 PHE D CG  1 
ATOM   8290 C  CD1 . PHE D 2 165 ? -53.653 -24.142 39.3    1    63.46  ? 335 PHE D CD1 1 
ATOM   8291 C  CD2 . PHE D 2 165 ? -55.242 -24.912 37.701  1    68.02  ? 335 PHE D CD2 1 
ATOM   8292 C  CE1 . PHE D 2 165 ? -53.314 -25.458 39.592  1    68.01  ? 335 PHE D CE1 1 
ATOM   8293 C  CE2 . PHE D 2 165 ? -54.916 -26.234 38.015  1    69.3   ? 335 PHE D CE2 1 
ATOM   8294 C  CZ  . PHE D 2 165 ? -53.947 -26.512 38.944  1    68.11  ? 335 PHE D CZ  1 
ATOM   8295 N  N   . LEU D 2 166 ? -54.026 -22.613 35.168  1    63.47  ? 336 LEU D N   1 
ATOM   8296 C  CA  . LEU D 2 166 ? -53.502 -23.382 34.047  1    62.73  ? 336 LEU D CA  1 
ATOM   8297 C  C   . LEU D 2 166 ? -52.299 -22.645 33.475  1    62.92  ? 336 LEU D C   1 
ATOM   8298 O  O   . LEU D 2 166 ? -51.282 -23.273 33.157  1    62.67  ? 336 LEU D O   1 
ATOM   8299 C  CB  . LEU D 2 166 ? -54.567 -23.582 32.97   1    61.04  ? 336 LEU D CB  1 
ATOM   8300 C  CG  . LEU D 2 166 ? -55.799 -24.395 33.371  1    63.56  ? 336 LEU D CG  1 
ATOM   8301 C  CD1 . LEU D 2 166 ? -56.815 -24.34  32.243  1    65.74  ? 336 LEU D CD1 1 
ATOM   8302 C  CD2 . LEU D 2 166 ? -55.466 -25.842 33.729  1    60.73  ? 336 LEU D CD2 1 
ATOM   8303 N  N   . GLY D 2 167 ? -52.451 -21.313 33.336  1    59.4   ? 337 GLY D N   1 
ATOM   8304 C  CA  . GLY D 2 167 ? -51.393 -20.449 32.836  1    54.63  ? 337 GLY D CA  1 
ATOM   8305 C  C   . GLY D 2 167 ? -50.103 -20.592 33.648  1    54.64  ? 337 GLY D C   1 
ATOM   8306 O  O   . GLY D 2 167 ? -49.015 -20.672 33.081  1    54.52  ? 337 GLY D O   1 
ATOM   8307 N  N   . GLU D 2 168 ? -50.24  -20.661 34.976  1    52.79  ? 338 GLU D N   1 
ATOM   8308 C  CA  . GLU D 2 168 ? -49.093 -20.804 35.86   1    51.44  ? 338 GLU D CA  1 
ATOM   8309 C  C   . GLU D 2 168 ? -48.442 -22.182 35.728  1    54.99  ? 338 GLU D C   1 
ATOM   8310 O  O   . GLU D 2 168 ? -47.215 -22.261 35.809  1    56.09  ? 338 GLU D O   1 
ATOM   8311 C  CB  . GLU D 2 168 ? -49.452 -20.528 37.316  1    46.88  ? 338 GLU D CB  1 
ATOM   8312 C  CG  . GLU D 2 168 ? -49.153 -19.103 37.738  1    46.25  ? 338 GLU D CG  1 
ATOM   8313 C  CD  . GLU D 2 168 ? -49.498 -18.79  39.187  1    53.9   ? 338 GLU D CD  1 
ATOM   8314 O  OE1 . GLU D 2 168 ? -48.964 -19.461 40.106  1    54.14  ? 338 GLU D OE1 1 
ATOM   8315 O  OE2 . GLU D 2 168 ? -50.289 -17.845 39.389  1    53.17  ? 338 GLU D OE2 1 
ATOM   8316 N  N   . LEU D 2 169 ? -49.243 -23.253 35.557  1    52.86  ? 339 LEU D N   1 
ATOM   8317 C  CA  . LEU D 2 169 ? -48.704 -24.602 35.436  1    52.99  ? 339 LEU D CA  1 
ATOM   8318 C  C   . LEU D 2 169 ? -47.746 -24.697 34.252  1    52.9   ? 339 LEU D C   1 
ATOM   8319 O  O   . LEU D 2 169 ? -46.74  -25.385 34.349  1    58.56  ? 339 LEU D O   1 
ATOM   8320 C  CB  . LEU D 2 169 ? -49.812 -25.643 35.284  1    60.36  ? 339 LEU D CB  1 
ATOM   8321 C  CG  . LEU D 2 169 ? -50.664 -25.982 36.513  1    58.75  ? 339 LEU D CG  1 
ATOM   8322 C  CD1 . LEU D 2 169 ? -51.709 -27.038 36.138  1    59.63  ? 339 LEU D CD1 1 
ATOM   8323 C  CD2 . LEU D 2 169 ? -49.798 -26.447 37.68   1    53.92  ? 339 LEU D CD2 1 
ATOM   8324 N  N   . SER D 2 170 ? -48.053 -23.984 33.157  1    51.36  ? 340 SER D N   1 
ATOM   8325 C  CA  . SER D 2 170 ? -47.249 -23.975 31.945  1    51.68  ? 340 SER D CA  1 
ATOM   8326 C  C   . SER D 2 170 ? -45.852 -23.395 32.183  1    53.68  ? 340 SER D C   1 
ATOM   8327 O  O   . SER D 2 170 ? -44.914 -23.745 31.465  1    54.43  ? 340 SER D O   1 
ATOM   8328 C  CB  . SER D 2 170 ? -47.975 -23.263 30.81   1    55.67  ? 340 SER D CB  1 
ATOM   8329 O  OG  . SER D 2 170 ? -47.859 -21.848 30.873  1    56.37  ? 340 SER D OG  1 
ATOM   8330 N  N   . LEU D 2 171 ? -45.708 -22.515 33.193  1    53.13  ? 341 LEU D N   1 
ATOM   8331 C  CA  . LEU D 2 171 ? -44.43  -21.896 33.558  1    46.72  ? 341 LEU D CA  1 
ATOM   8332 C  C   . LEU D 2 171 ? -43.399 -22.957 33.958  1    47.54  ? 341 LEU D C   1 
ATOM   8333 O  O   . LEU D 2 171 ? -42.212 -22.755 33.764  1    48.85  ? 341 LEU D O   1 
ATOM   8334 C  CB  . LEU D 2 171 ? -44.603 -20.899 34.711  1    42.86  ? 341 LEU D CB  1 
ATOM   8335 C  CG  . LEU D 2 171 ? -45.471 -19.663 34.444  1    40.05  ? 341 LEU D CG  1 
ATOM   8336 C  CD1 . LEU D 2 171 ? -45.528 -18.735 35.642  1    36.52  ? 341 LEU D CD1 1 
ATOM   8337 C  CD2 . LEU D 2 171 ? -45.026 -18.88  33.192  1    41.62  ? 341 LEU D CD2 1 
ATOM   8338 N  N   . ILE D 2 172 ? -43.859 -24.064 34.559  1    48.63  ? 342 ILE D N   1 
ATOM   8339 C  CA  . ILE D 2 172 ? -43.007 -25.029 35.225  1    50.39  ? 342 ILE D CA  1 
ATOM   8340 C  C   . ILE D 2 172 ? -42.243 -25.875 34.195  1    53.82  ? 342 ILE D C   1 
ATOM   8341 O  O   . ILE D 2 172 ? -41.092 -26.265 34.425  1    51.19  ? 342 ILE D O   1 
ATOM   8342 C  CB  . ILE D 2 172 ? -43.872 -25.906 36.152  1    51.79  ? 342 ILE D CB  1 
ATOM   8343 C  CG1 . ILE D 2 172 ? -44.541 -25.108 37.272  1    47.53  ? 342 ILE D CG1 1 
ATOM   8344 C  CG2 . ILE D 2 172 ? -43.081 -27.105 36.688  1    54.14  ? 342 ILE D CG2 1 
ATOM   8345 C  CD1 . ILE D 2 172 ? -43.596 -24.655 38.367  1    47.05  ? 342 ILE D CD1 1 
ATOM   8346 N  N   . ASP D 2 173 ? -42.904 -26.182 33.071  1    53     ? 343 ASP D N   1 
ATOM   8347 C  CA  . ASP D 2 173 ? -42.458 -27.22  32.151  1    53.4   ? 343 ASP D CA  1 
ATOM   8348 C  C   . ASP D 2 173 ? -42.038 -26.583 30.827  1    56.39  ? 343 ASP D C   1 
ATOM   8349 O  O   . ASP D 2 173 ? -42.881 -26.318 29.97   1    59.96  ? 343 ASP D O   1 
ATOM   8350 C  CB  . ASP D 2 173 ? -43.574 -28.221 31.902  1    54.96  ? 343 ASP D CB  1 
ATOM   8351 C  CG  . ASP D 2 173 ? -44.063 -28.92  33.156  1    58.29  ? 343 ASP D CG  1 
ATOM   8352 O  OD1 . ASP D 2 173 ? -43.203 -29.463 33.864  1    58.56  ? 343 ASP D OD1 1 
ATOM   8353 O  OD2 . ASP D 2 173 ? -45.288 -28.907 33.407  1    62.09  ? 343 ASP D OD2 1 
ATOM   8354 N  N   . ALA D 2 174 ? -40.725 -26.398 30.656  1    54.59  ? 344 ALA D N   1 
ATOM   8355 C  CA  . ALA D 2 174 ? -40.142 -25.769 29.48   1    56.97  ? 344 ALA D CA  1 
ATOM   8356 C  C   . ALA D 2 174 ? -40.457 -26.584 28.222  1    58.62  ? 344 ALA D C   1 
ATOM   8357 O  O   . ALA D 2 174 ? -40.57  -26.023 27.132  1    56.55  ? 344 ALA D O   1 
ATOM   8358 C  CB  . ALA D 2 174 ? -38.646 -25.651 29.674  1    58.54  ? 344 ALA D CB  1 
ATOM   8359 N  N   . ASP D 2 175 ? -40.485 -27.911 28.386  1    53.75  ? 345 ASP D N   1 
ATOM   8360 C  CA  . ASP D 2 175 ? -40.999 -28.831 27.4    1    59.45  ? 345 ASP D CA  1 
ATOM   8361 C  C   . ASP D 2 175 ? -42.373 -29.25  27.911  1    63.21  ? 345 ASP D C   1 
ATOM   8362 O  O   . ASP D 2 175 ? -42.451 -29.924 28.935  1    61.02  ? 345 ASP D O   1 
ATOM   8363 C  CB  . ASP D 2 175 ? -40.08  -30.037 27.194  1    65.35  ? 345 ASP D CB  1 
ATOM   8364 C  CG  . ASP D 2 175 ? -40.634 -31.142 26.296  1    71.87  ? 345 ASP D CG  1 
ATOM   8365 O  OD1 . ASP D 2 175 ? -41.598 -30.876 25.542  1    72.52  ? 345 ASP D OD1 1 
ATOM   8366 O  OD2 . ASP D 2 175 ? -40.117 -32.274 26.362  1    72.9   ? 345 ASP D OD2 1 
ATOM   8367 N  N   . PRO D 2 176 ? -43.485 -28.921 27.204  1    63.33  ? 346 PRO D N   1 
ATOM   8368 C  CA  . PRO D 2 176 ? -43.44  -28.25  25.895  1    59.92  ? 346 PRO D CA  1 
ATOM   8369 C  C   . PRO D 2 176 ? -43.564 -26.728 25.765  1    56.79  ? 346 PRO D C   1 
ATOM   8370 O  O   . PRO D 2 176 ? -43.379 -26.197 24.676  1    61.14  ? 346 PRO D O   1 
ATOM   8371 C  CB  . PRO D 2 176 ? -44.631 -28.935 25.232  1    58.11  ? 346 PRO D CB  1 
ATOM   8372 C  CG  . PRO D 2 176 ? -45.642 -29.038 26.338  1    57.53  ? 346 PRO D CG  1 
ATOM   8373 C  CD  . PRO D 2 176 ? -44.849 -29.293 27.602  1    57.95  ? 346 PRO D CD  1 
ATOM   8374 N  N   . TYR D 2 177 ? -43.84  -26.013 26.855  1    52.01  ? 347 TYR D N   1 
ATOM   8375 C  CA  . TYR D 2 177 ? -44.404 -24.671 26.741  1    50.58  ? 347 TYR D CA  1 
ATOM   8376 C  C   . TYR D 2 177 ? -43.472 -23.589 26.154  1    55.52  ? 347 TYR D C   1 
ATOM   8377 O  O   . TYR D 2 177 ? -43.96  -22.547 25.698  1    54.72  ? 347 TYR D O   1 
ATOM   8378 C  CB  . TYR D 2 177 ? -45.126 -24.305 28.042  1    48.64  ? 347 TYR D CB  1 
ATOM   8379 C  CG  . TYR D 2 177 ? -46.245 -25.286 28.323  1    53.48  ? 347 TYR D CG  1 
ATOM   8380 C  CD1 . TYR D 2 177 ? -47.392 -25.3   27.528  1    57.39  ? 347 TYR D CD1 1 
ATOM   8381 C  CD2 . TYR D 2 177 ? -46.125 -26.254 29.311  1    56.03  ? 347 TYR D CD2 1 
ATOM   8382 C  CE1 . TYR D 2 177 ? -48.389 -26.246 27.707  1    60.12  ? 347 TYR D CE1 1 
ATOM   8383 C  CE2 . TYR D 2 177 ? -47.129 -27.194 29.503  1    59.46  ? 347 TYR D CE2 1 
ATOM   8384 C  CZ  . TYR D 2 177 ? -48.264 -27.2   28.705  1    59.59  ? 347 TYR D CZ  1 
ATOM   8385 O  OH  . TYR D 2 177 ? -49.258 -28.117 28.933  1    58.58  ? 347 TYR D OH  1 
ATOM   8386 N  N   . LEU D 2 178 ? -42.145 -23.792 26.136  1    55.65  ? 348 LEU D N   1 
ATOM   8387 C  CA  . LEU D 2 178 ? -41.257 -22.831 25.483  1    53.22  ? 348 LEU D CA  1 
ATOM   8388 C  C   . LEU D 2 178 ? -41.595 -22.656 23.996  1    56.14  ? 348 LEU D C   1 
ATOM   8389 O  O   . LEU D 2 178 ? -41.202 -21.648 23.398  1    59.53  ? 348 LEU D O   1 
ATOM   8390 C  CB  . LEU D 2 178 ? -39.783 -23.212 25.614  1    56.53  ? 348 LEU D CB  1 
ATOM   8391 C  CG  . LEU D 2 178 ? -39.1   -22.958 26.958  1    59.2   ? 348 LEU D CG  1 
ATOM   8392 C  CD1 . LEU D 2 178 ? -37.665 -23.464 26.861  1    59.56  ? 348 LEU D CD1 1 
ATOM   8393 C  CD2 . LEU D 2 178 ? -39.11  -21.488 27.295  1    48.89  ? 348 LEU D CD2 1 
ATOM   8394 N  N   . LYS D 2 179 ? -42.286 -23.635 23.39   1    52.06  ? 349 LYS D N   1 
ATOM   8395 C  CA  . LYS D 2 179 ? -42.595 -23.499 21.98   1    55.87  ? 349 LYS D CA  1 
ATOM   8396 C  C   . LYS D 2 179 ? -43.848 -22.654 21.758  1    58.3   ? 349 LYS D C   1 
ATOM   8397 O  O   . LYS D 2 179 ? -44.075 -22.22  20.635  1    66.35  ? 349 LYS D O   1 
ATOM   8398 C  CB  . LYS D 2 179 ? -42.609 -24.813 21.203  1    53.78  ? 349 LYS D CB  1 
ATOM   8399 C  CG  . LYS D 2 179 ? -43.727 -25.767 21.538  1    61.52  ? 349 LYS D CG  1 
ATOM   8400 C  CD  . LYS D 2 179 ? -43.466 -27.168 20.969  1    74.43  ? 349 LYS D CD  1 
ATOM   8401 C  CE  . LYS D 2 179 ? -44.062 -28.289 21.759  1    78.22  ? 349 LYS D CE  1 
ATOM   8402 N  NZ  . LYS D 2 179 ? -44.008 -29.544 21      1    83.64  ? 349 LYS D NZ  1 
ATOM   8403 N  N   . TYR D 2 180 ? -44.648 -22.404 22.806  1    54.66  ? 350 TYR D N   1 
ATOM   8404 C  CA  . TYR D 2 180 ? -45.847 -21.587 22.659  1    53.71  ? 350 TYR D CA  1 
ATOM   8405 C  C   . TYR D 2 180 ? -45.591 -20.163 23.149  1    54.18  ? 350 TYR D C   1 
ATOM   8406 O  O   . TYR D 2 180 ? -44.936 -19.956 24.176  1    61.7   ? 350 TYR D O   1 
ATOM   8407 C  CB  . TYR D 2 180 ? -47.022 -22.276 23.349  1    55.54  ? 350 TYR D CB  1 
ATOM   8408 C  CG  . TYR D 2 180 ? -47.265 -23.698 22.852  1    57.24  ? 350 TYR D CG  1 
ATOM   8409 C  CD1 . TYR D 2 180 ? -47.549 -23.943 21.514  1    57.55  ? 350 TYR D CD1 1 
ATOM   8410 C  CD2 . TYR D 2 180 ? -47.209 -24.782 23.724  1    52.94  ? 350 TYR D CD2 1 
ATOM   8411 C  CE1 . TYR D 2 180 ? -47.76  -25.229 21.056  1    62.63  ? 350 TYR D CE1 1 
ATOM   8412 C  CE2 . TYR D 2 180 ? -47.444 -26.069 23.282  1    55.58  ? 350 TYR D CE2 1 
ATOM   8413 C  CZ  . TYR D 2 180 ? -47.699 -26.293 21.943  1    62.5   ? 350 TYR D CZ  1 
ATOM   8414 O  OH  . TYR D 2 180 ? -47.903 -27.555 21.476  1    67.9   ? 350 TYR D OH  1 
ATOM   8415 N  N   . LEU D 2 181 ? -46.075 -19.189 22.364  1    50.89  ? 351 LEU D N   1 
ATOM   8416 C  CA  . LEU D 2 181 ? -46.079 -17.775 22.704  1    50.29  ? 351 LEU D CA  1 
ATOM   8417 C  C   . LEU D 2 181 ? -47.062 -17.527 23.844  1    51.1   ? 351 LEU D C   1 
ATOM   8418 O  O   . LEU D 2 181 ? -48.078 -18.202 23.96   1    51.17  ? 351 LEU D O   1 
ATOM   8419 C  CB  . LEU D 2 181 ? -46.459 -16.939 21.484  1    50.49  ? 351 LEU D CB  1 
ATOM   8420 C  CG  . LEU D 2 181 ? -45.391 -16.747 20.4    1    52.18  ? 351 LEU D CG  1 
ATOM   8421 C  CD1 . LEU D 2 181 ? -45.94  -16.015 19.186  1    51.68  ? 351 LEU D CD1 1 
ATOM   8422 C  CD2 . LEU D 2 181 ? -44.183 -16.001 20.96   1    48.87  ? 351 LEU D CD2 1 
ATOM   8423 N  N   . PRO D 2 182 ? -46.829 -16.502 24.694  1    52.12  ? 352 PRO D N   1 
ATOM   8424 C  CA  . PRO D 2 182 ? -47.733 -16.208 25.815  1    51.8   ? 352 PRO D CA  1 
ATOM   8425 C  C   . PRO D 2 182 ? -49.195 -16.11  25.416  1    55.42  ? 352 PRO D C   1 
ATOM   8426 O  O   . PRO D 2 182 ? -50.057 -16.654 26.107  1    62.33  ? 352 PRO D O   1 
ATOM   8427 C  CB  . PRO D 2 182 ? -47.22  -14.882 26.339  1    52.71  ? 352 PRO D CB  1 
ATOM   8428 C  CG  . PRO D 2 182 ? -45.731 -14.906 25.984  1    51.82  ? 352 PRO D CG  1 
ATOM   8429 C  CD  . PRO D 2 182 ? -45.67  -15.598 24.625  1    51.71  ? 352 PRO D CD  1 
ATOM   8430 N  N   . SER D 2 183 ? -49.452 -15.427 24.292  1    51.44  ? 353 SER D N   1 
ATOM   8431 C  CA  . SER D 2 183 ? -50.8   -15.181 23.823  1    50.57  ? 353 SER D CA  1 
ATOM   8432 C  C   . SER D 2 183 ? -51.512 -16.493 23.507  1    55.18  ? 353 SER D C   1 
ATOM   8433 O  O   . SER D 2 183 ? -52.725 -16.586 23.711  1    57.51  ? 353 SER D O   1 
ATOM   8434 C  CB  . SER D 2 183 ? -50.808 -14.275 22.638  1    52.51  ? 353 SER D CB  1 
ATOM   8435 O  OG  . SER D 2 183 ? -50.183 -14.932 21.555  1    59.41  ? 353 SER D OG  1 
ATOM   8436 N  N   . VAL D 2 184 ? -50.758 -17.475 22.986  1    53.48  ? 354 VAL D N   1 
ATOM   8437 C  CA  . VAL D 2 184 ? -51.276 -18.807 22.675  1    54.13  ? 354 VAL D CA  1 
ATOM   8438 C  C   . VAL D 2 184 ? -51.59  -19.595 23.955  1    52.86  ? 354 VAL D C   1 
ATOM   8439 O  O   . VAL D 2 184 ? -52.705 -20.069 24.144  1    54.59  ? 354 VAL D O   1 
ATOM   8440 C  CB  . VAL D 2 184 ? -50.37  -19.606 21.719  1    52.74  ? 354 VAL D CB  1 
ATOM   8441 C  CG1 . VAL D 2 184 ? -50.874 -21.016 21.505  1    50.15  ? 354 VAL D CG1 1 
ATOM   8442 C  CG2 . VAL D 2 184 ? -50.207 -18.891 20.383  1    55.11  ? 354 VAL D CG2 1 
ATOM   8443 N  N   . ILE D 2 185 ? -50.618 -19.721 24.858  1    51.27  ? 355 ILE D N   1 
ATOM   8444 C  CA  . ILE D 2 185 ? -50.885 -20.397 26.117  1    50.74  ? 355 ILE D CA  1 
ATOM   8445 C  C   . ILE D 2 185 ? -52.039 -19.726 26.852  1    57.8   ? 355 ILE D C   1 
ATOM   8446 O  O   . ILE D 2 185 ? -52.832 -20.424 27.481  1    63.22  ? 355 ILE D O   1 
ATOM   8447 C  CB  . ILE D 2 185 ? -49.629 -20.448 26.985  1    44.97  ? 355 ILE D CB  1 
ATOM   8448 C  CG1 . ILE D 2 185 ? -48.568 -21.334 26.342  1    45.62  ? 355 ILE D CG1 1 
ATOM   8449 C  CG2 . ILE D 2 185 ? -49.958 -20.888 28.406  1    45.13  ? 355 ILE D CG2 1 
ATOM   8450 C  CD1 . ILE D 2 185 ? -47.181 -21.116 26.929  1    41.16  ? 355 ILE D CD1 1 
ATOM   8451 N  N   . ALA D 2 186 ? -52.13  -18.385 26.783  1    57.79  ? 356 ALA D N   1 
ATOM   8452 C  CA  . ALA D 2 186 ? -53.228 -17.672 27.425  1    55.33  ? 356 ALA D CA  1 
ATOM   8453 C  C   . ALA D 2 186 ? -54.575 -18.056 26.807  1    61.47  ? 356 ALA D C   1 
ATOM   8454 O  O   . ALA D 2 186 ? -55.551 -18.245 27.537  1    63.87  ? 356 ALA D O   1 
ATOM   8455 C  CB  . ALA D 2 186 ? -53.019 -16.197 27.336  1    50.3   ? 356 ALA D CB  1 
ATOM   8456 N  N   . ALA D 2 187 ? -54.623 -18.172 25.467  1    59.96  ? 357 ALA D N   1 
ATOM   8457 C  CA  . ALA D 2 187 ? -55.823 -18.582 24.744  1    60.88  ? 357 ALA D CA  1 
ATOM   8458 C  C   . ALA D 2 187 ? -56.212 -20.023 25.103  1    62.89  ? 357 ALA D C   1 
ATOM   8459 O  O   . ALA D 2 187 ? -57.367 -20.29  25.412  1    61.98  ? 357 ALA D O   1 
ATOM   8460 C  CB  . ALA D 2 187 ? -55.622 -18.403 23.257  1    58.16  ? 357 ALA D CB  1 
ATOM   8461 N  N   . ALA D 2 188 ? -55.25  -20.954 25.074  1    62.67  ? 358 ALA D N   1 
ATOM   8462 C  CA  . ALA D 2 188 ? -55.503 -22.331 25.474  1    67.21  ? 358 ALA D CA  1 
ATOM   8463 C  C   . ALA D 2 188 ? -56.028 -22.391 26.91   1    67.76  ? 358 ALA D C   1 
ATOM   8464 O  O   . ALA D 2 188 ? -57.018 -23.062 27.203  1    69.1   ? 358 ALA D O   1 
ATOM   8465 C  CB  . ALA D 2 188 ? -54.248 -23.155 25.31   1    61.57  ? 358 ALA D CB  1 
ATOM   8466 N  N   . ALA D 2 189 ? -55.365 -21.66  27.802  1    63.89  ? 359 ALA D N   1 
ATOM   8467 C  CA  . ALA D 2 189 ? -55.716 -21.681 29.209  1    65.9   ? 359 ALA D CA  1 
ATOM   8468 C  C   . ALA D 2 189 ? -57.132 -21.139 29.433  1    70.24  ? 359 ALA D C   1 
ATOM   8469 O  O   . ALA D 2 189 ? -57.809 -21.57  30.367  1    69.92  ? 359 ALA D O   1 
ATOM   8470 C  CB  . ALA D 2 189 ? -54.676 -20.908 29.99   1    56.82  ? 359 ALA D CB  1 
ATOM   8471 N  N   . PHE D 2 190 ? -57.552 -20.171 28.6    1    67.38  ? 360 PHE D N   1 
ATOM   8472 C  CA  . PHE D 2 190 ? -58.849 -19.526 28.737  1    66.85  ? 360 PHE D CA  1 
ATOM   8473 C  C   . PHE D 2 190 ? -59.955 -20.439 28.198  1    71.83  ? 360 PHE D C   1 
ATOM   8474 O  O   . PHE D 2 190 ? -60.948 -20.68  28.887  1    78.45  ? 360 PHE D O   1 
ATOM   8475 C  CB  . PHE D 2 190 ? -58.864 -18.165 28.039  1    61.49  ? 360 PHE D CB  1 
ATOM   8476 C  CG  . PHE D 2 190 ? -60.189 -17.427 28.112  1    61.19  ? 360 PHE D CG  1 
ATOM   8477 C  CD1 . PHE D 2 190 ? -60.771 -17.126 29.335  1    63.02  ? 360 PHE D CD1 1 
ATOM   8478 C  CD2 . PHE D 2 190 ? -60.848 -17.039 26.96   1    63.86  ? 360 PHE D CD2 1 
ATOM   8479 C  CE1 . PHE D 2 190 ? -61.979 -16.452 29.402  1    64.05  ? 360 PHE D CE1 1 
ATOM   8480 C  CE2 . PHE D 2 190 ? -62.057 -16.373 27.03   1    67.37  ? 360 PHE D CE2 1 
ATOM   8481 C  CZ  . PHE D 2 190 ? -62.618 -16.072 28.251  1    67.74  ? 360 PHE D CZ  1 
ATOM   8482 N  N   . HIS D 2 191 ? -59.777 -20.955 26.973  1    70.39  ? 361 HIS D N   1 
ATOM   8483 C  CA  . HIS D 2 191 ? -60.733 -21.887 26.394  1    77.52  ? 361 HIS D CA  1 
ATOM   8484 C  C   . HIS D 2 191 ? -60.939 -23.078 27.329  1    78.19  ? 361 HIS D C   1 
ATOM   8485 O  O   . HIS D 2 191 ? -62.069 -23.502 27.576  1    84.08  ? 361 HIS D O   1 
ATOM   8486 C  CB  . HIS D 2 191 ? -60.297 -22.429 25.023  1    77.37  ? 361 HIS D CB  1 
ATOM   8487 C  CG  . HIS D 2 191 ? -61.164 -23.585 24.609  1    81.68  ? 361 HIS D CG  1 
ATOM   8488 N  ND1 . HIS D 2 191 ? -62.295 -23.431 23.834  1    82.44  ? 361 HIS D ND1 1 
ATOM   8489 C  CD2 . HIS D 2 191 ? -61.116 -24.893 24.925  1    76.63  ? 361 HIS D CD2 1 
ATOM   8490 C  CE1 . HIS D 2 191 ? -62.875 -24.609 23.657  1    79.86  ? 361 HIS D CE1 1 
ATOM   8491 N  NE2 . HIS D 2 191 ? -62.181 -25.501 24.314  1    78.36  ? 361 HIS D NE2 1 
ATOM   8492 N  N   . LEU D 2 192 ? -59.826 -23.626 27.814  1    72.1   ? 362 LEU D N   1 
ATOM   8493 C  CA  . LEU D 2 192 ? -59.857 -24.807 28.644  1    71.4   ? 362 LEU D CA  1 
ATOM   8494 C  C   . LEU D 2 192 ? -60.621 -24.546 29.939  1    73.43  ? 362 LEU D C   1 
ATOM   8495 O  O   . LEU D 2 192 ? -61.431 -25.378 30.345  1    77.17  ? 362 LEU D O   1 
ATOM   8496 C  CB  . LEU D 2 192 ? -58.411 -25.21  28.88   1    70.63  ? 362 LEU D CB  1 
ATOM   8497 C  CG  . LEU D 2 192 ? -58.209 -26.567 29.55   1    78.24  ? 362 LEU D CG  1 
ATOM   8498 C  CD1 . LEU D 2 192 ? -59.153 -27.603 28.946  1    77.14  ? 362 LEU D CD1 1 
ATOM   8499 C  CD2 . LEU D 2 192 ? -56.765 -27.001 29.426  1    76.73  ? 362 LEU D CD2 1 
ATOM   8500 N  N   . ALA D 2 193 ? -60.39  -23.381 30.555  1    72.76  ? 363 ALA D N   1 
ATOM   8501 C  CA  . ALA D 2 193 ? -60.981 -23.017 31.84   1    78.42  ? 363 ALA D CA  1 
ATOM   8502 C  C   . ALA D 2 193 ? -62.447 -22.628 31.687  1    84.46  ? 363 ALA D C   1 
ATOM   8503 O  O   . ALA D 2 193 ? -63.266 -22.905 32.564  1    90.09  ? 363 ALA D O   1 
ATOM   8504 C  CB  . ALA D 2 193 ? -60.217 -21.888 32.483  1    66.88  ? 363 ALA D CB  1 
ATOM   8505 N  N   . LEU D 2 194 ? -62.747 -21.938 30.583  1    83.49  ? 364 LEU D N   1 
ATOM   8506 C  CA  . LEU D 2 194 ? -64.1   -21.569 30.215  1    84.21  ? 364 LEU D CA  1 
ATOM   8507 C  C   . LEU D 2 194 ? -64.941 -22.838 30.005  1    90.73  ? 364 LEU D C   1 
ATOM   8508 O  O   . LEU D 2 194 ? -66.04  -22.969 30.56   1    95.87  ? 364 LEU D O   1 
ATOM   8509 C  CB  . LEU D 2 194 ? -63.954 -20.724 28.948  1    81.72  ? 364 LEU D CB  1 
ATOM   8510 C  CG  . LEU D 2 194 ? -65.188 -19.974 28.434  1    90.72  ? 364 LEU D CG  1 
ATOM   8511 C  CD1 . LEU D 2 194 ? -65.586 -18.798 29.326  1    87.37  ? 364 LEU D CD1 1 
ATOM   8512 C  CD2 . LEU D 2 194 ? -64.9   -19.497 27.018  1    90.3   ? 364 LEU D CD2 1 
ATOM   8513 N  N   . TYR D 2 195 ? -64.387 -23.802 29.251  1    86.11  ? 365 TYR D N   1 
ATOM   8514 C  CA  . TYR D 2 195 ? -65.045 -25.054 28.911  1    84.18  ? 365 TYR D CA  1 
ATOM   8515 C  C   . TYR D 2 195 ? -65.328 -25.878 30.163  1    83.19  ? 365 TYR D C   1 
ATOM   8516 O  O   . TYR D 2 195 ? -66.41  -26.435 30.29   1    87.9   ? 365 TYR D O   1 
ATOM   8517 C  CB  . TYR D 2 195 ? -64.152 -25.84  27.948  1    86.89  ? 365 TYR D CB  1 
ATOM   8518 C  CG  . TYR D 2 195 ? -64.723 -27.135 27.377  1    92.6   ? 365 TYR D CG  1 
ATOM   8519 C  CD1 . TYR D 2 195 ? -65.653 -27.118 26.337  1    97.28  ? 365 TYR D CD1 1 
ATOM   8520 C  CD2 . TYR D 2 195 ? -64.314 -28.379 27.852  1    90.96  ? 365 TYR D CD2 1 
ATOM   8521 C  CE1 . TYR D 2 195 ? -66.164 -28.288 25.794  1    98.94  ? 365 TYR D CE1 1 
ATOM   8522 C  CE2 . TYR D 2 195 ? -64.809 -29.554 27.307  1    95.45  ? 365 TYR D CE2 1 
ATOM   8523 C  CZ  . TYR D 2 195 ? -65.739 -29.515 26.278  1    99.79  ? 365 TYR D CZ  1 
ATOM   8524 O  OH  . TYR D 2 195 ? -66.262 -30.661 25.738  1    104.16 ? 365 TYR D OH  1 
ATOM   8525 N  N   . THR D 2 196 ? -64.345 -25.956 31.071  1    80.18  ? 366 THR D N   1 
ATOM   8526 C  CA  . THR D 2 196 ? -64.43  -26.747 32.291  1    80.62  ? 366 THR D CA  1 
ATOM   8527 C  C   . THR D 2 196 ? -65.56  -26.24  33.187  1    81.88  ? 366 THR D C   1 
ATOM   8528 O  O   . THR D 2 196 ? -66.304 -27.027 33.761  1    85.2   ? 366 THR D O   1 
ATOM   8529 C  CB  . THR D 2 196 ? -63.083 -26.749 33.015  1    80.84  ? 366 THR D CB  1 
ATOM   8530 O  OG1 . THR D 2 196 ? -62.089 -27.293 32.144  1    76.62  ? 366 THR D OG1 1 
ATOM   8531 C  CG2 . THR D 2 196 ? -63.144 -27.489 34.347  1    81.61  ? 366 THR D CG2 1 
ATOM   8532 N  N   . VAL D 2 197 ? -65.711 -24.917 33.279  1    79.38  ? 367 VAL D N   1 
ATOM   8533 C  CA  . VAL D 2 197 ? -66.639 -24.335 34.233  1    82.17  ? 367 VAL D CA  1 
ATOM   8534 C  C   . VAL D 2 197 ? -68.036 -24.226 33.617  1    86.04  ? 367 VAL D C   1 
ATOM   8535 O  O   . VAL D 2 197 ? -69.014 -24.608 34.259  1    87.11  ? 367 VAL D O   1 
ATOM   8536 C  CB  . VAL D 2 197 ? -66.108 -22.98  34.741  1    78.65  ? 367 VAL D CB  1 
ATOM   8537 C  CG1 . VAL D 2 197 ? -67.094 -22.288 35.673  1    82.51  ? 367 VAL D CG1 1 
ATOM   8538 C  CG2 . VAL D 2 197 ? -64.768 -23.127 35.44   1    76.86  ? 367 VAL D CG2 1 
ATOM   8539 N  N   . THR D 2 198 ? -68.116 -23.721 32.372  1    86.93  ? 368 THR D N   1 
ATOM   8540 C  CA  . THR D 2 198 ? -69.38  -23.313 31.754  1    91.77  ? 368 THR D CA  1 
ATOM   8541 C  C   . THR D 2 198 ? -69.838 -24.258 30.635  1    95.72  ? 368 THR D C   1 
ATOM   8542 O  O   . THR D 2 198 ? -71.036 -24.323 30.341  1    101.43 ? 368 THR D O   1 
ATOM   8543 C  CB  . THR D 2 198 ? -69.321 -21.869 31.244  1    88.02  ? 368 THR D CB  1 
ATOM   8544 O  OG1 . THR D 2 198 ? -68.566 -21.824 30.033  1    87.22  ? 368 THR D OG1 1 
ATOM   8545 C  CG2 . THR D 2 198 ? -68.766 -20.912 32.281  1    83.33  ? 368 THR D CG2 1 
ATOM   8546 N  N   . GLY D 2 199 ? -68.888 -24.947 29.982  1    93.5   ? 369 GLY D N   1 
ATOM   8547 C  CA  . GLY D 2 199 ? -69.169 -25.775 28.816  1    92.39  ? 369 GLY D CA  1 
ATOM   8548 C  C   . GLY D 2 199 ? -68.967 -25.007 27.508  1    90.24  ? 369 GLY D C   1 
ATOM   8549 O  O   . GLY D 2 199 ? -69.002 -25.585 26.427  1    87.76  ? 369 GLY D O   1 
ATOM   8550 N  N   . GLN D 2 200 ? -68.732 -23.699 27.611  1    93.19  ? 370 GLN D N   1 
ATOM   8551 C  CA  . GLN D 2 200 ? -68.614 -22.849 26.434  1    99.83  ? 370 GLN D CA  1 
ATOM   8552 C  C   . GLN D 2 200 ? -67.217 -22.961 25.832  1    94.5   ? 370 GLN D C   1 
ATOM   8553 O  O   . GLN D 2 200 ? -66.294 -23.5   26.44   1    87     ? 370 GLN D O   1 
ATOM   8554 C  CB  . GLN D 2 200 ? -68.859 -21.368 26.741  1    107.59 ? 370 GLN D CB  1 
ATOM   8555 C  CG  . GLN D 2 200 ? -70.281 -21.023 27.176  1    114.3  ? 370 GLN D CG  1 
ATOM   8556 C  CD  . GLN D 2 200 ? -71.338 -21.362 26.149  1    126.52 ? 370 GLN D CD  1 
ATOM   8557 O  OE1 . GLN D 2 200 ? -71.145 -21.166 24.934  1    127.35 ? 370 GLN D OE1 1 
ATOM   8558 N  NE2 . GLN D 2 200 ? -72.478 -21.841 26.647  1    120.53 ? 370 GLN D NE2 1 
ATOM   8559 N  N   . SER D 2 201 ? -67.087 -22.405 24.625  1    93.98  ? 371 SER D N   1 
ATOM   8560 C  CA  . SER D 2 201 ? -65.851 -22.469 23.871  1    91.99  ? 371 SER D CA  1 
ATOM   8561 C  C   . SER D 2 201 ? -65.3   -21.067 23.627  1    91.32  ? 371 SER D C   1 
ATOM   8562 O  O   . SER D 2 201 ? -65.986 -20.067 23.787  1    97.09  ? 371 SER D O   1 
ATOM   8563 C  CB  . SER D 2 201 ? -66.044 -23.227 22.585  1    92.42  ? 371 SER D CB  1 
ATOM   8564 O  OG  . SER D 2 201 ? -66.288 -24.6   22.854  1    96.42  ? 371 SER D OG  1 
ATOM   8565 N  N   . TRP D 2 202 ? -64.028 -21.025 23.255  1    88.35  ? 372 TRP D N   1 
ATOM   8566 C  CA  . TRP D 2 202 ? -63.36  -19.847 22.734  1    86.31  ? 372 TRP D CA  1 
ATOM   8567 C  C   . TRP D 2 202 ? -64.35  -18.998 21.932  1    91.76  ? 372 TRP D C   1 
ATOM   8568 O  O   . TRP D 2 202 ? -64.803 -19.418 20.855  1    97.78  ? 372 TRP D O   1 
ATOM   8569 C  CB  . TRP D 2 202 ? -62.198 -20.36  21.869  1    85.2   ? 372 TRP D CB  1 
ATOM   8570 C  CG  . TRP D 2 202 ? -61.275 -19.323 21.294  1    82.03  ? 372 TRP D CG  1 
ATOM   8571 C  CD1 . TRP D 2 202 ? -61.098 -19.057 19.97   1    78.58  ? 372 TRP D CD1 1 
ATOM   8572 C  CD2 . TRP D 2 202 ? -60.371 -18.453 22.016  1    81.57  ? 372 TRP D CD2 1 
ATOM   8573 N  NE1 . TRP D 2 202 ? -60.148 -18.082 19.809  1    79.59  ? 372 TRP D NE1 1 
ATOM   8574 C  CE2 . TRP D 2 202 ? -59.689 -17.686 21.041  1    79.32  ? 372 TRP D CE2 1 
ATOM   8575 C  CE3 . TRP D 2 202 ? -60.072 -18.239 23.373  1    79.1   ? 372 TRP D CE3 1 
ATOM   8576 C  CZ2 . TRP D 2 202 ? -58.743 -16.724 21.393  1    73.85  ? 372 TRP D CZ2 1 
ATOM   8577 C  CZ3 . TRP D 2 202 ? -59.137 -17.286 23.72   1    73.18  ? 372 TRP D CZ3 1 
ATOM   8578 C  CH2 . TRP D 2 202 ? -58.493 -16.537 22.736  1    73.67  ? 372 TRP D CH2 1 
ATOM   8579 N  N   . PRO D 2 203 ? -64.748 -17.8   22.439  1    85.38  ? 373 PRO D N   1 
ATOM   8580 C  CA  . PRO D 2 203 ? -65.779 -16.981 21.79   1    83.71  ? 373 PRO D CA  1 
ATOM   8581 C  C   . PRO D 2 203 ? -65.345 -16.396 20.453  1    79.99  ? 373 PRO D C   1 
ATOM   8582 O  O   . PRO D 2 203 ? -64.158 -16.188 20.216  1    74.93  ? 373 PRO D O   1 
ATOM   8583 C  CB  . PRO D 2 203 ? -66.118 -15.887 22.817  1    81.74  ? 373 PRO D CB  1 
ATOM   8584 C  CG  . PRO D 2 203 ? -64.879 -15.804 23.664  1    80.34  ? 373 PRO D CG  1 
ATOM   8585 C  CD  . PRO D 2 203 ? -64.267 -17.194 23.684  1    80.71  ? 373 PRO D CD  1 
ATOM   8586 N  N   . GLU D 2 204 ? -66.34  -16.128 19.606  1    84.76  ? 374 GLU D N   1 
ATOM   8587 C  CA  . GLU D 2 204 ? -66.144 -15.62  18.257  1    88.81  ? 374 GLU D CA  1 
ATOM   8588 C  C   . GLU D 2 204 ? -65.442 -14.256 18.278  1    88.86  ? 374 GLU D C   1 
ATOM   8589 O  O   . GLU D 2 204 ? -64.698 -13.913 17.347  1    88     ? 374 GLU D O   1 
ATOM   8590 C  CB  . GLU D 2 204 ? -67.518 -15.589 17.582  1    93.16  ? 374 GLU D CB  1 
ATOM   8591 C  CG  . GLU D 2 204 ? -67.535 -14.939 16.199  1    97.75  ? 374 GLU D CG  1 
ATOM   8592 C  CD  . GLU D 2 204 ? -66.54  -15.48  15.184  1    98.15  ? 374 GLU D CD  1 
ATOM   8593 O  OE1 . GLU D 2 204 ? -66.128 -16.658 15.247  1    95.78  ? 374 GLU D OE1 1 
ATOM   8594 O  OE2 . GLU D 2 204 ? -66.141 -14.684 14.322  1    98.96  ? 374 GLU D OE2 1 
ATOM   8595 N  N   . SER D 2 205 ? -65.715 -13.475 19.338  1    81.68  ? 375 SER D N   1 
ATOM   8596 C  CA  . SER D 2 205 ? -65.182 -12.134 19.507  1    79.38  ? 375 SER D CA  1 
ATOM   8597 C  C   . SER D 2 205 ? -63.656 -12.164 19.649  1    77.09  ? 375 SER D C   1 
ATOM   8598 O  O   . SER D 2 205 ? -62.947 -11.347 19.051  1    72.22  ? 375 SER D O   1 
ATOM   8599 C  CB  . SER D 2 205 ? -65.852 -11.431 20.667  1    78.59  ? 375 SER D CB  1 
ATOM   8600 O  OG  . SER D 2 205 ? -65.848 -12.256 21.821  1    80.37  ? 375 SER D OG  1 
ATOM   8601 N  N   . LEU D 2 206 ? -63.172 -13.125 20.441  1    73.85  ? 376 LEU D N   1 
ATOM   8602 C  CA  . LEU D 2 206 ? -61.751 -13.341 20.644  1    71.71  ? 376 LEU D CA  1 
ATOM   8603 C  C   . LEU D 2 206 ? -61.093 -13.93  19.393  1    74.19  ? 376 LEU D C   1 
ATOM   8604 O  O   . LEU D 2 206 ? -59.933 -13.615 19.123  1    75.53  ? 376 LEU D O   1 
ATOM   8605 C  CB  . LEU D 2 206 ? -61.513 -14.205 21.877  1    66.42  ? 376 LEU D CB  1 
ATOM   8606 C  CG  . LEU D 2 206 ? -61.651 -13.475 23.217  1    63.91  ? 376 LEU D CG  1 
ATOM   8607 C  CD1 . LEU D 2 206 ? -61.476 -14.447 24.368  1    63.72  ? 376 LEU D CD1 1 
ATOM   8608 C  CD2 . LEU D 2 206 ? -60.661 -12.332 23.341  1    58.14  ? 376 LEU D CD2 1 
ATOM   8609 N  N   . VAL D 2 207 ? -61.82  -14.758 18.63   1    68.65  ? 377 VAL D N   1 
ATOM   8610 C  CA  . VAL D 2 207 ? -61.333 -15.166 17.327  1    69.28  ? 377 VAL D CA  1 
ATOM   8611 C  C   . VAL D 2 207 ? -61.071 -13.918 16.481  1    72.14  ? 377 VAL D C   1 
ATOM   8612 O  O   . VAL D 2 207 ? -60.033 -13.801 15.829  1    70.69  ? 377 VAL D O   1 
ATOM   8613 C  CB  . VAL D 2 207 ? -62.302 -16.133 16.614  1    73.25  ? 377 VAL D CB  1 
ATOM   8614 C  CG1 . VAL D 2 207 ? -61.821 -16.515 15.214  1    69.9   ? 377 VAL D CG1 1 
ATOM   8615 C  CG2 . VAL D 2 207 ? -62.547 -17.372 17.46   1    71.58  ? 377 VAL D CG2 1 
ATOM   8616 N  N   . GLN D 2 208 ? -62.014 -12.974 16.49   1    75.44  ? 378 GLN D N   1 
ATOM   8617 C  CA  . GLN D 2 208 ? -61.833 -11.757 15.711  1    79.01  ? 378 GLN D CA  1 
ATOM   8618 C  C   . GLN D 2 208 ? -60.643 -10.953 16.248  1    75.44  ? 378 GLN D C   1 
ATOM   8619 O  O   . GLN D 2 208 ? -59.827 -10.466 15.474  1    73.95  ? 378 GLN D O   1 
ATOM   8620 C  CB  . GLN D 2 208 ? -63.145 -10.972 15.629  1    87.79  ? 378 GLN D CB  1 
ATOM   8621 C  CG  . GLN D 2 208 ? -64.167 -11.586 14.677  1    98.13  ? 378 GLN D CG  1 
ATOM   8622 C  CD  . GLN D 2 208 ? -63.692 -11.591 13.238  1    102.27 ? 378 GLN D CD  1 
ATOM   8623 O  OE1 . GLN D 2 208 ? -63.201 -12.602 12.722  1    93.39  ? 378 GLN D OE1 1 
ATOM   8624 N  NE2 . GLN D 2 208 ? -63.784 -10.435 12.596  1    109.15 ? 378 GLN D NE2 1 
ATOM   8625 N  N   . LYS D 2 209 ? -60.531 -10.82  17.576  1    69.83  ? 379 LYS D N   1 
ATOM   8626 C  CA  . LYS D 2 209 ? -59.468 -10.039 18.181  1    68.11  ? 379 LYS D CA  1 
ATOM   8627 C  C   . LYS D 2 209 ? -58.098 -10.621 17.842  1    69.51  ? 379 LYS D C   1 
ATOM   8628 O  O   . LYS D 2 209 ? -57.249 -9.879  17.344  1    65.01  ? 379 LYS D O   1 
ATOM   8629 C  CB  . LYS D 2 209 ? -59.607 -9.983  19.709  1    71.42  ? 379 LYS D CB  1 
ATOM   8630 C  CG  . LYS D 2 209 ? -58.655 -9.001  20.402  1    68.21  ? 379 LYS D CG  1 
ATOM   8631 C  CD  . LYS D 2 209 ? -58.801 -9.027  21.92   1    72.96  ? 379 LYS D CD  1 
ATOM   8632 C  CE  . LYS D 2 209 ? -57.856 -8.141  22.673  1    67.24  ? 379 LYS D CE  1 
ATOM   8633 N  NZ  . LYS D 2 209 ? -58.186 -6.73   22.455  1    73.15  ? 379 LYS D NZ  1 
ATOM   8634 N  N   . THR D 2 210 ? -57.911 -11.934 18.115  1    70.45  ? 380 THR D N   1 
ATOM   8635 C  CA  . THR D 2 210 ? -56.609 -12.613 18.15   1    69.89  ? 380 THR D CA  1 
ATOM   8636 C  C   . THR D 2 210 ? -56.211 -13.222 16.806  1    71.55  ? 380 THR D C   1 
ATOM   8637 O  O   . THR D 2 210 ? -55.022 -13.371 16.532  1    70.2   ? 380 THR D O   1 
ATOM   8638 C  CB  . THR D 2 210 ? -56.57  -13.741 19.179  1    69.41  ? 380 THR D CB  1 
ATOM   8639 O  OG1 . THR D 2 210 ? -57.451 -14.767 18.713  1    71.39  ? 380 THR D OG1 1 
ATOM   8640 C  CG2 . THR D 2 210 ? -56.875 -13.253 20.583  1    66.97  ? 380 THR D CG2 1 
ATOM   8641 N  N   . GLY D 2 211 ? -57.202 -13.667 16.024  1    73.41  ? 381 GLY D N   1 
ATOM   8642 C  CA  . GLY D 2 211 ? -56.923 -14.413 14.813  1    67.67  ? 381 GLY D CA  1 
ATOM   8643 C  C   . GLY D 2 211 ? -56.741 -15.907 15.075  1    68.98  ? 381 GLY D C   1 
ATOM   8644 O  O   . GLY D 2 211 ? -56.522 -16.641 14.121  1    75.23  ? 381 GLY D O   1 
ATOM   8645 N  N   . TYR D 2 212 ? -56.872 -16.356 16.333  1    70.22  ? 382 TYR D N   1 
ATOM   8646 C  CA  . TYR D 2 212 ? -56.705 -17.758 16.698  1    74.01  ? 382 TYR D CA  1 
ATOM   8647 C  C   . TYR D 2 212 ? -58.058 -18.472 16.649  1    79.43  ? 382 TYR D C   1 
ATOM   8648 O  O   . TYR D 2 212 ? -59.072 -17.897 17.057  1    80.31  ? 382 TYR D O   1 
ATOM   8649 C  CB  . TYR D 2 212 ? -56.081 -17.946 18.09   1    68.11  ? 382 TYR D CB  1 
ATOM   8650 C  CG  . TYR D 2 212 ? -54.746 -17.263 18.338  1    64.62  ? 382 TYR D CG  1 
ATOM   8651 C  CD1 . TYR D 2 212 ? -53.809 -17.077 17.317  1    65.23  ? 382 TYR D CD1 1 
ATOM   8652 C  CD2 . TYR D 2 212 ? -54.421 -16.802 19.609  1    60.8   ? 382 TYR D CD2 1 
ATOM   8653 C  CE1 . TYR D 2 212 ? -52.598 -16.437 17.574  1    62.33  ? 382 TYR D CE1 1 
ATOM   8654 C  CE2 . TYR D 2 212 ? -53.22  -16.162 19.878  1    55.82  ? 382 TYR D CE2 1 
ATOM   8655 C  CZ  . TYR D 2 212 ? -52.307 -15.978 18.857  1    58.11  ? 382 TYR D CZ  1 
ATOM   8656 O  OH  . TYR D 2 212 ? -51.137 -15.356 19.166  1    54.01  ? 382 TYR D OH  1 
ATOM   8657 N  N   . THR D 2 213 ? -58.053 -19.716 16.137  1    77.05  ? 383 THR D N   1 
ATOM   8658 C  CA  . THR D 2 213 ? -59.212 -20.592 16.18   1    80.63  ? 383 THR D CA  1 
ATOM   8659 C  C   . THR D 2 213 ? -58.871 -21.807 17.033  1    81.71  ? 383 THR D C   1 
ATOM   8660 O  O   . THR D 2 213 ? -57.695 -22.05  17.299  1    85.33  ? 383 THR D O   1 
ATOM   8661 C  CB  . THR D 2 213 ? -59.623 -20.978 14.764  1    83.23  ? 383 THR D CB  1 
ATOM   8662 O  OG1 . THR D 2 213 ? -58.573 -21.773 14.224  1    88.03  ? 383 THR D OG1 1 
ATOM   8663 C  CG2 . THR D 2 213 ? -59.862 -19.763 13.884  1    83.44  ? 383 THR D CG2 1 
ATOM   8664 N  N   . LEU D 2 214 ? -59.902 -22.545 17.47   1    85.18  ? 384 LEU D N   1 
ATOM   8665 C  CA  . LEU D 2 214 ? -59.695 -23.793 18.196  1    88.33  ? 384 LEU D CA  1 
ATOM   8666 C  C   . LEU D 2 214 ? -58.753 -24.709 17.41   1    90.02  ? 384 LEU D C   1 
ATOM   8667 O  O   . LEU D 2 214 ? -57.969 -25.457 17.995  1    88.6   ? 384 LEU D O   1 
ATOM   8668 C  CB  . LEU D 2 214 ? -61.006 -24.484 18.578  1    84.99  ? 384 LEU D CB  1 
ATOM   8669 C  CG  . LEU D 2 214 ? -61.822 -23.834 19.701  1    80.54  ? 384 LEU D CG  1 
ATOM   8670 C  CD1 . LEU D 2 214 ? -63.064 -24.63  19.987  1    83.7   ? 384 LEU D CD1 1 
ATOM   8671 C  CD2 . LEU D 2 214 ? -61.021 -23.726 20.968  1    81.08  ? 384 LEU D CD2 1 
ATOM   8672 N  N   . GLU D 2 215 ? -58.8   -24.589 16.077  1    92.45  ? 385 GLU D N   1 
ATOM   8673 C  CA  . GLU D 2 215 ? -57.907 -25.329 15.203  1    93.26  ? 385 GLU D CA  1 
ATOM   8674 C  C   . GLU D 2 215 ? -56.456 -24.927 15.49   1    93.16  ? 385 GLU D C   1 
ATOM   8675 O  O   . GLU D 2 215 ? -55.637 -25.776 15.823  1    92.05  ? 385 GLU D O   1 
ATOM   8676 C  CB  . GLU D 2 215 ? -58.364 -25.196 13.747  1    94.59  ? 385 GLU D CB  1 
ATOM   8677 C  CG  . GLU D 2 215 ? -58.111 -26.466 12.939  1    103.27 ? 385 GLU D CG  1 
ATOM   8678 C  CD  . GLU D 2 215 ? -58.208 -26.287 11.439  1    113.96 ? 385 GLU D CD  1 
ATOM   8679 O  OE1 . GLU D 2 215 ? -58.983 -27.064 10.848  1    121.56 ? 385 GLU D OE1 1 
ATOM   8680 O  OE2 . GLU D 2 215 ? -57.532 -25.386 10.886  1    110.41 ? 385 GLU D OE2 1 
ATOM   8681 N  N   . THR D 2 216 ? -56.132 -23.63  15.397  1    85.09  ? 386 THR D N   1 
ATOM   8682 C  CA  . THR D 2 216 ? -54.761 -23.187 15.596  1    88.15  ? 386 THR D CA  1 
ATOM   8683 C  C   . THR D 2 216 ? -54.309 -23.393 17.048  1    85.51  ? 386 THR D C   1 
ATOM   8684 O  O   . THR D 2 216 ? -53.115 -23.564 17.303  1    79.45  ? 386 THR D O   1 
ATOM   8685 C  CB  . THR D 2 216 ? -54.579 -21.744 15.117  1    94.55  ? 386 THR D CB  1 
ATOM   8686 O  OG1 . THR D 2 216 ? -55.494 -20.921 15.844  1    100.35 ? 386 THR D OG1 1 
ATOM   8687 C  CG2 . THR D 2 216 ? -54.753 -21.607 13.609  1    86.14  ? 386 THR D CG2 1 
ATOM   8688 N  N   . LEU D 2 217 ? -55.268 -23.386 17.992  1    79.53  ? 387 LEU D N   1 
ATOM   8689 C  CA  . LEU D 2 217 ? -54.978 -23.5   19.414  1    67.51  ? 387 LEU D CA  1 
ATOM   8690 C  C   . LEU D 2 217 ? -54.86  -24.965 19.83   1    69.56  ? 387 LEU D C   1 
ATOM   8691 O  O   . LEU D 2 217 ? -54.621 -25.242 20.994  1    73.46  ? 387 LEU D O   1 
ATOM   8692 C  CB  . LEU D 2 217 ? -56.08  -22.845 20.238  1    62.97  ? 387 LEU D CB  1 
ATOM   8693 C  CG  . LEU D 2 217 ? -56.224 -21.33  20.143  1    62     ? 387 LEU D CG  1 
ATOM   8694 C  CD1 . LEU D 2 217 ? -57.353 -20.859 21.065  1    60.54  ? 387 LEU D CD1 1 
ATOM   8695 C  CD2 . LEU D 2 217 ? -54.918 -20.635 20.499  1    59.52  ? 387 LEU D CD2 1 
ATOM   8696 N  N   . LYS D 2 218 ? -55.084 -25.908 18.917  1    69.9   ? 388 LYS D N   1 
ATOM   8697 C  CA  . LYS D 2 218 ? -55.273 -27.293 19.316  1    77.27  ? 388 LYS D CA  1 
ATOM   8698 C  C   . LYS D 2 218 ? -53.975 -27.9   19.839  1    79     ? 388 LYS D C   1 
ATOM   8699 O  O   . LYS D 2 218 ? -53.993 -28.526 20.903  1    83.3   ? 388 LYS D O   1 
ATOM   8700 C  CB  . LYS D 2 218 ? -55.85  -28.133 18.167  1    84.94  ? 388 LYS D CB  1 
ATOM   8701 C  CG  . LYS D 2 218 ? -56.386 -29.508 18.526  1    87.47  ? 388 LYS D CG  1 
ATOM   8702 C  CD  . LYS D 2 218 ? -56.612 -30.361 17.28   1    94.26  ? 388 LYS D CD  1 
ATOM   8703 C  CE  . LYS D 2 218 ? -55.34  -30.657 16.527  1    96.51  ? 388 LYS D CE  1 
ATOM   8704 N  NZ  . LYS D 2 218 ? -55.497 -31.837 15.658  1    97.99  ? 388 LYS D NZ  1 
ATOM   8705 N  N   . PRO D 2 219 ? -52.824 -27.792 19.119  1    77.95  ? 389 PRO D N   1 
ATOM   8706 C  CA  . PRO D 2 219 ? -51.556 -28.32  19.645  1    75.79  ? 389 PRO D CA  1 
ATOM   8707 C  C   . PRO D 2 219 ? -51.365 -27.933 21.11   1    72.01  ? 389 PRO D C   1 
ATOM   8708 O  O   . PRO D 2 219 ? -51.305 -28.816 21.969  1    72.49  ? 389 PRO D O   1 
ATOM   8709 C  CB  . PRO D 2 219 ? -50.48  -27.733 18.714  1    73.31  ? 389 PRO D CB  1 
ATOM   8710 C  CG  . PRO D 2 219 ? -51.238 -27.556 17.397  1    72.74  ? 389 PRO D CG  1 
ATOM   8711 C  CD  . PRO D 2 219 ? -52.666 -27.164 17.792  1    73.09  ? 389 PRO D CD  1 
ATOM   8712 N  N   . CYS D 2 220 ? -51.399 -26.632 21.406  1    67.65  ? 390 CYS D N   1 
ATOM   8713 C  CA  . CYS D 2 220 ? -51.195 -26.145 22.798  1    69.78  ? 390 CYS D CA  1 
ATOM   8714 C  C   . CYS D 2 220 ? -52.281 -26.703 23.726  1    69.12  ? 390 CYS D C   1 
ATOM   8715 O  O   . CYS D 2 220 ? -51.933 -27.142 24.835  1    68.57  ? 390 CYS D O   1 
ATOM   8716 C  CB  . CYS D 2 220 ? -51.178 -24.619 22.845  1    66     ? 390 CYS D CB  1 
ATOM   8717 S  SG  . CYS D 2 220 ? -50.809 -23.915 24.472  1    62.39  ? 390 CYS D SG  1 
ATOM   8718 N  N   . LEU D 2 221 ? -53.535 -26.696 23.284  1    70.22  ? 391 LEU D N   1 
ATOM   8719 C  CA  . LEU D 2 221 ? -54.65  -27.138 24.16   1    72.66  ? 391 LEU D CA  1 
ATOM   8720 C  C   . LEU D 2 221 ? -54.482 -28.616 24.533  1    71.91  ? 391 LEU D C   1 
ATOM   8721 O  O   . LEU D 2 221 ? -54.811 -28.974 25.669  1    73.14  ? 391 LEU D O   1 
ATOM   8722 C  CB  . LEU D 2 221 ? -55.985 -26.872 23.473  1    82.43  ? 391 LEU D CB  1 
ATOM   8723 C  CG  . LEU D 2 221 ? -56.781 -25.675 23.998  1    91.73  ? 391 LEU D CG  1 
ATOM   8724 C  CD1 . LEU D 2 221 ? -57.8   -25.216 22.972  1    85.12  ? 391 LEU D CD1 1 
ATOM   8725 C  CD2 . LEU D 2 221 ? -57.458 -26.032 25.304  1    92.98  ? 391 LEU D CD2 1 
ATOM   8726 N  N   . LEU D 2 222 ? -53.967 -29.428 23.616  1    73.17  ? 392 LEU D N   1 
ATOM   8727 C  CA  . LEU D 2 222 ? -53.739 -30.863 23.914  1    78.41  ? 392 LEU D CA  1 
ATOM   8728 C  C   . LEU D 2 222 ? -52.666 -30.989 24.995  1    78.61  ? 392 LEU D C   1 
ATOM   8729 O  O   . LEU D 2 222 ? -52.887 -31.728 25.967  1    86.47  ? 392 LEU D O   1 
ATOM   8730 C  CB  . LEU D 2 222 ? -53.333 -31.59  22.637  1    77.99  ? 392 LEU D CB  1 
ATOM   8731 C  CG  . LEU D 2 222 ? -54.399 -31.641 21.54   1    77.17  ? 392 LEU D CG  1 
ATOM   8732 C  CD1 . LEU D 2 222 ? -53.847 -32.249 20.267  1    76.92  ? 392 LEU D CD1 1 
ATOM   8733 C  CD2 . LEU D 2 222 ? -55.62  -32.396 22.021  1    76.41  ? 392 LEU D CD2 1 
ATOM   8734 N  N   . ASP D 2 223 ? -51.55  -30.294 24.815  1    78.28  ? 393 ASP D N   1 
ATOM   8735 C  CA  . ASP D 2 223 ? -50.452 -30.336 25.811  1    77.58  ? 393 ASP D CA  1 
ATOM   8736 C  C   . ASP D 2 223 ? -50.998 -29.83  27.146  1    74.24  ? 393 ASP D C   1 
ATOM   8737 O  O   . ASP D 2 223 ? -50.689 -30.445 28.178  1    76.38  ? 393 ASP D O   1 
ATOM   8738 C  CB  . ASP D 2 223 ? -49.247 -29.545 25.324  1    77.49  ? 393 ASP D CB  1 
ATOM   8739 C  CG  . ASP D 2 223 ? -48.423 -30.172 24.215  1    75.72  ? 393 ASP D CG  1 
ATOM   8740 O  OD1 . ASP D 2 223 ? -48.021 -31.338 24.376  1    85.52  ? 393 ASP D OD1 1 
ATOM   8741 O  OD2 . ASP D 2 223 ? -48.174 -29.477 23.214  1    71.66  ? 393 ASP D OD2 1 
ATOM   8742 N  N   . LEU D 2 224 ? -51.774 -28.751 27.122  1    66.4   ? 394 LEU D N   1 
ATOM   8743 C  CA  . LEU D 2 224 ? -52.284 -28.156 28.381  1    64.44  ? 394 LEU D CA  1 
ATOM   8744 C  C   . LEU D 2 224 ? -53.305 -29.108 28.987  1    66.67  ? 394 LEU D C   1 
ATOM   8745 O  O   . LEU D 2 224 ? -53.239 -29.358 30.2    1    68.89  ? 394 LEU D O   1 
ATOM   8746 C  CB  . LEU D 2 224 ? -52.885 -26.777 28.127  1    64.46  ? 394 LEU D CB  1 
ATOM   8747 C  CG  . LEU D 2 224 ? -52.968 -25.848 29.34   1    60.48  ? 394 LEU D CG  1 
ATOM   8748 C  CD1 . LEU D 2 224 ? -51.64  -25.778 30.066  1    55.14  ? 394 LEU D CD1 1 
ATOM   8749 C  CD2 . LEU D 2 224 ? -53.394 -24.473 28.884  1    56.97  ? 394 LEU D CD2 1 
ATOM   8750 N  N   . HIS D 2 225 ? -54.227 -29.595 28.169  1    70.22  ? 395 HIS D N   1 
ATOM   8751 C  CA  . HIS D 2 225 ? -55.155 -30.597 28.667  1    70.17  ? 395 HIS D CA  1 
ATOM   8752 C  C   . HIS D 2 225 ? -54.394 -31.705 29.402  1    71.45  ? 395 HIS D C   1 
ATOM   8753 O  O   . HIS D 2 225 ? -54.761 -32.066 30.516  1    75.82  ? 395 HIS D O   1 
ATOM   8754 C  CB  . HIS D 2 225 ? -56.001 -31.156 27.524  1    74.38  ? 395 HIS D CB  1 
ATOM   8755 C  CG  . HIS D 2 225 ? -57.155 -32.02  27.949  1    76.36  ? 395 HIS D CG  1 
ATOM   8756 N  ND1 . HIS D 2 225 ? -57.851 -31.815 29.124  1    72.97  ? 395 HIS D ND1 1 
ATOM   8757 C  CD2 . HIS D 2 225 ? -57.728 -33.072 27.347  1    76.35  ? 395 HIS D CD2 1 
ATOM   8758 C  CE1 . HIS D 2 225 ? -58.815 -32.699 29.219  1    75.86  ? 395 HIS D CE1 1 
ATOM   8759 N  NE2 . HIS D 2 225 ? -58.765 -33.471 28.149  1    78.86  ? 395 HIS D NE2 1 
ATOM   8760 N  N   . GLN D 2 226 ? -53.333 -32.231 28.776  1    70.06  ? 396 GLN D N   1 
ATOM   8761 C  CA  . GLN D 2 226 ? -52.544 -33.32  29.329  1    71.98  ? 396 GLN D CA  1 
ATOM   8762 C  C   . GLN D 2 226 ? -51.912 -32.853 30.641  1    71.2   ? 396 GLN D C   1 
ATOM   8763 O  O   . GLN D 2 226 ? -52.001 -33.533 31.651  1    72.81  ? 396 GLN D O   1 
ATOM   8764 C  CB  . GLN D 2 226 ? -51.55  -33.854 28.293  1    74.05  ? 396 GLN D CB  1 
ATOM   8765 C  CG  . GLN D 2 226 ? -51.251 -35.346 28.4    1    86.53  ? 396 GLN D CG  1 
ATOM   8766 C  CD  . GLN D 2 226 ? -52.497 -36.23  28.448  1    104.28 ? 396 GLN D CD  1 
ATOM   8767 O  OE1 . GLN D 2 226 ? -53.399 -36.155 27.601  1    104.8  ? 396 GLN D OE1 1 
ATOM   8768 N  NE2 . GLN D 2 226 ? -52.579 -37.098 29.452  1    104.18 ? 396 GLN D NE2 1 
ATOM   8769 N  N   . THR D 2 227 ? -51.341 -31.643 30.649  1    68.5   ? 397 THR D N   1 
ATOM   8770 C  CA  . THR D 2 227 ? -50.716 -31.092 31.847  1    69.03  ? 397 THR D CA  1 
ATOM   8771 C  C   . THR D 2 227 ? -51.748 -31.022 32.981  1    73.68  ? 397 THR D C   1 
ATOM   8772 O  O   . THR D 2 227 ? -51.452 -31.378 34.127  1    73.07  ? 397 THR D O   1 
ATOM   8773 C  CB  . THR D 2 227 ? -50.066 -29.734 31.563  1    60.64  ? 397 THR D CB  1 
ATOM   8774 O  OG1 . THR D 2 227 ? -49.007 -29.919 30.632  1    58.53  ? 397 THR D OG1 1 
ATOM   8775 C  CG2 . THR D 2 227 ? -49.465 -29.093 32.798  1    57.11  ? 397 THR D CG2 1 
ATOM   8776 N  N   . TYR D 2 228 ? -52.965 -30.56  32.654  1    74.55  ? 398 TYR D N   1 
ATOM   8777 C  CA  . TYR D 2 228 ? -54.004 -30.354 33.657  1    75.29  ? 398 TYR D CA  1 
ATOM   8778 C  C   . TYR D 2 228 ? -54.295 -31.684 34.344  1    80.19  ? 398 TYR D C   1 
ATOM   8779 O  O   . TYR D 2 228 ? -54.34  -31.748 35.573  1    84.26  ? 398 TYR D O   1 
ATOM   8780 C  CB  . TYR D 2 228 ? -55.244 -29.724 33.007  1    75     ? 398 TYR D CB  1 
ATOM   8781 C  CG  . TYR D 2 228 ? -56.369 -29.275 33.934  1    75.24  ? 398 TYR D CG  1 
ATOM   8782 C  CD1 . TYR D 2 228 ? -56.249 -29.335 35.327  1    72.84  ? 398 TYR D CD1 1 
ATOM   8783 C  CD2 . TYR D 2 228 ? -57.556 -28.756 33.403  1    75.24  ? 398 TYR D CD2 1 
ATOM   8784 C  CE1 . TYR D 2 228 ? -57.286 -28.906 36.147  1    75.79  ? 398 TYR D CE1 1 
ATOM   8785 C  CE2 . TYR D 2 228 ? -58.603 -28.335 34.217  1    77.07  ? 398 TYR D CE2 1 
ATOM   8786 C  CZ  . TYR D 2 228 ? -58.459 -28.398 35.599  1    77.38  ? 398 TYR D CZ  1 
ATOM   8787 O  OH  . TYR D 2 228 ? -59.448 -27.968 36.443  1    72.58  ? 398 TYR D OH  1 
ATOM   8788 N  N   . LEU D 2 229 ? -54.456 -32.733 33.522  1    80.78  ? 399 LEU D N   1 
ATOM   8789 C  CA  . LEU D 2 229 ? -54.82  -34.085 33.929  1    83.72  ? 399 LEU D CA  1 
ATOM   8790 C  C   . LEU D 2 229 ? -53.768 -34.71  34.841  1    84.67  ? 399 LEU D C   1 
ATOM   8791 O  O   . LEU D 2 229 ? -54.116 -35.406 35.788  1    83.13  ? 399 LEU D O   1 
ATOM   8792 C  CB  . LEU D 2 229 ? -55.025 -34.936 32.677  1    82.01  ? 399 LEU D CB  1 
ATOM   8793 C  CG  . LEU D 2 229 ? -56.311 -34.702 31.878  1    79.49  ? 399 LEU D CG  1 
ATOM   8794 C  CD1 . LEU D 2 229 ? -56.242 -35.429 30.542  1    79.51  ? 399 LEU D CD1 1 
ATOM   8795 C  CD2 . LEU D 2 229 ? -57.501 -35.182 32.656  1    77.64  ? 399 LEU D CD2 1 
ATOM   8796 N  N   . ARG D 2 230 ? -52.488 -34.466 34.542  1    89.81  ? 400 ARG D N   1 
ATOM   8797 C  CA  . ARG D 2 230 ? -51.38  -35.132 35.219  1    93.71  ? 400 ARG D CA  1 
ATOM   8798 C  C   . ARG D 2 230 ? -50.948 -34.309 36.432  1    85.77  ? 400 ARG D C   1 
ATOM   8799 O  O   . ARG D 2 230 ? -50.155 -34.786 37.244  1    82.91  ? 400 ARG D O   1 
ATOM   8800 C  CB  . ARG D 2 230 ? -50.242 -35.397 34.218  1    96.38  ? 400 ARG D CB  1 
ATOM   8801 C  CG  . ARG D 2 230 ? -50.603 -36.467 33.194  1    102.8  ? 400 ARG D CG  1 
ATOM   8802 C  CD  . ARG D 2 230 ? -50.022 -36.337 31.789  1    107.74 ? 400 ARG D CD  1 
ATOM   8803 N  NE  . ARG D 2 230 ? -50.05  -37.66  31.15   1    119.93 ? 400 ARG D NE  1 
ATOM   8804 C  CZ  . ARG D 2 230 ? -49.372 -38.084 30.072  1    120.5  ? 400 ARG D CZ  1 
ATOM   8805 N  NH1 . ARG D 2 230 ? -48.614 -37.261 29.351  1    121.62 ? 400 ARG D NH1 1 
ATOM   8806 N  NH2 . ARG D 2 230 ? -49.466 -39.356 29.712  1    121.47 ? 400 ARG D NH2 1 
ATOM   8807 N  N   . ALA D 2 231 ? -51.524 -33.103 36.555  1    78.91  ? 401 ALA D N   1 
ATOM   8808 C  CA  . ALA D 2 231 ? -51.089 -32.1   37.522  1    76.89  ? 401 ALA D CA  1 
ATOM   8809 C  C   . ALA D 2 231 ? -50.961 -32.672 38.938  1    75.71  ? 401 ALA D C   1 
ATOM   8810 O  O   . ALA D 2 231 ? -49.97  -32.39  39.61   1    75.45  ? 401 ALA D O   1 
ATOM   8811 C  CB  . ALA D 2 231 ? -51.973 -30.862 37.467  1    69.74  ? 401 ALA D CB  1 
ATOM   8812 N  N   . PRO D 2 232 ? -51.945 -33.458 39.447  1    78.03  ? 402 PRO D N   1 
ATOM   8813 C  CA  . PRO D 2 232 ? -51.823 -34.081 40.771  1    78.75  ? 402 PRO D CA  1 
ATOM   8814 C  C   . PRO D 2 232 ? -50.615 -34.984 41.005  1    77.99  ? 402 PRO D C   1 
ATOM   8815 O  O   . PRO D 2 232 ? -50.32  -35.291 42.155  1    74.98  ? 402 PRO D O   1 
ATOM   8816 C  CB  . PRO D 2 232 ? -53.128 -34.88  40.937  1    79.42  ? 402 PRO D CB  1 
ATOM   8817 C  CG  . PRO D 2 232 ? -54.093 -34.214 39.986  1    79.1   ? 402 PRO D CG  1 
ATOM   8818 C  CD  . PRO D 2 232 ? -53.246 -33.741 38.807  1    77.02  ? 402 PRO D CD  1 
ATOM   8819 N  N   . GLN D 2 233 ? -49.957 -35.421 39.914  1    81.39  ? 403 GLN D N   1 
ATOM   8820 C  CA  . GLN D 2 233 ? -48.824 -36.346 39.953  1    84.2   ? 403 GLN D CA  1 
ATOM   8821 C  C   . GLN D 2 233 ? -47.507 -35.672 39.561  1    78.35  ? 403 GLN D C   1 
ATOM   8822 O  O   . GLN D 2 233 ? -46.461 -36.327 39.568  1    80.73  ? 403 GLN D O   1 
ATOM   8823 C  CB  . GLN D 2 233 ? -48.991 -37.546 39.012  1    88.68  ? 403 GLN D CB  1 
ATOM   8824 C  CG  . GLN D 2 233 ? -49.602 -38.79  39.641  1    89.81  ? 403 GLN D CG  1 
ATOM   8825 C  CD  . GLN D 2 233 ? -51.088 -38.665 39.863  1    91.85  ? 403 GLN D CD  1 
ATOM   8826 O  OE1 . GLN D 2 233 ? -51.577 -38.903 40.97   1    98.75  ? 403 GLN D OE1 1 
ATOM   8827 N  NE2 . GLN D 2 233 ? -51.819 -38.303 38.817  1    89.24  ? 403 GLN D NE2 1 
ATOM   8828 N  N   . HIS D 2 234 ? -47.556 -34.384 39.192  1    70.12  ? 404 HIS D N   1 
ATOM   8829 C  CA  . HIS D 2 234 ? -46.36  -33.637 38.859  1    62.87  ? 404 HIS D CA  1 
ATOM   8830 C  C   . HIS D 2 234 ? -45.457 -33.595 40.099  1    63.07  ? 404 HIS D C   1 
ATOM   8831 O  O   . HIS D 2 234 ? -45.951 -33.473 41.216  1    63.59  ? 404 HIS D O   1 
ATOM   8832 C  CB  . HIS D 2 234 ? -46.776 -32.258 38.337  1    62.96  ? 404 HIS D CB  1 
ATOM   8833 C  CG  . HIS D 2 234 ? -45.706 -31.571 37.543  1    66.72  ? 404 HIS D CG  1 
ATOM   8834 N  ND1 . HIS D 2 234 ? -44.462 -31.251 38.063  1    64.93  ? 404 HIS D ND1 1 
ATOM   8835 C  CD2 . HIS D 2 234 ? -45.69  -31.175 36.262  1    64.95  ? 404 HIS D CD2 1 
ATOM   8836 C  CE1 . HIS D 2 234 ? -43.731 -30.668 37.13   1    66.07  ? 404 HIS D CE1 1 
ATOM   8837 N  NE2 . HIS D 2 234 ? -44.46  -30.62  36.024  1    69.8   ? 404 HIS D NE2 1 
ATOM   8838 N  N   . ALA D 2 235 ? -44.134 -33.707 39.918  1    60.48  ? 405 ALA D N   1 
ATOM   8839 C  CA  . ALA D 2 235 ? -43.186 -33.58  41.016  1    60.29  ? 405 ALA D CA  1 
ATOM   8840 C  C   . ALA D 2 235 ? -43.328 -32.221 41.713  1    61.84  ? 405 ALA D C   1 
ATOM   8841 O  O   . ALA D 2 235 ? -42.953 -32.092 42.878  1    65.82  ? 405 ALA D O   1 
ATOM   8842 C  CB  . ALA D 2 235 ? -41.763 -33.772 40.523  1    54.85  ? 405 ALA D CB  1 
ATOM   8843 N  N   . GLN D 2 236 ? -43.85  -31.214 40.997  1    59.49  ? 406 GLN D N   1 
ATOM   8844 C  CA  . GLN D 2 236 ? -44.023 -29.851 41.501  1    62.64  ? 406 GLN D CA  1 
ATOM   8845 C  C   . GLN D 2 236 ? -45.506 -29.513 41.703  1    64.96  ? 406 GLN D C   1 
ATOM   8846 O  O   . GLN D 2 236 ? -46.311 -29.624 40.773  1    66.2   ? 406 GLN D O   1 
ATOM   8847 C  CB  . GLN D 2 236 ? -43.324 -28.833 40.594  1    56.72  ? 406 GLN D CB  1 
ATOM   8848 C  CG  . GLN D 2 236 ? -41.837 -28.68  40.861  1    53.28  ? 406 GLN D CG  1 
ATOM   8849 C  CD  . GLN D 2 236 ? -41.035 -29.865 40.393  1    63.45  ? 406 GLN D CD  1 
ATOM   8850 O  OE1 . GLN D 2 236 ? -41.194 -30.337 39.259  1    72.08  ? 406 GLN D OE1 1 
ATOM   8851 N  NE2 . GLN D 2 236 ? -40.158 -30.349 41.262  1    64.07  ? 406 GLN D NE2 1 
ATOM   8852 N  N   . GLN D 2 237 ? -45.819 -29.052 42.928  1    63.18  ? 407 GLN D N   1 
ATOM   8853 C  CA  . GLN D 2 237 ? -47.163 -28.995 43.471  1    65.49  ? 407 GLN D CA  1 
ATOM   8854 C  C   . GLN D 2 237 ? -47.548 -27.614 44.007  1    66.32  ? 407 GLN D C   1 
ATOM   8855 O  O   . GLN D 2 237 ? -48.743 -27.411 44.279  1    71.29  ? 407 GLN D O   1 
ATOM   8856 C  CB  . GLN D 2 237 ? -47.276 -30.006 44.614  1    65.73  ? 407 GLN D CB  1 
ATOM   8857 C  CG  . GLN D 2 237 ? -47.25  -31.453 44.148  1    67.63  ? 407 GLN D CG  1 
ATOM   8858 C  CD  . GLN D 2 237 ? -48.354 -31.735 43.158  1    73.56  ? 407 GLN D CD  1 
ATOM   8859 O  OE1 . GLN D 2 237 ? -49.518 -31.354 43.359  1    78.54  ? 407 GLN D OE1 1 
ATOM   8860 N  NE2 . GLN D 2 237 ? -47.987 -32.354 42.049  1    75.74  ? 407 GLN D NE2 1 
ATOM   8861 N  N   . SER D 2 238 ? -46.577 -26.682 44.138  1    62.3   ? 408 SER D N   1 
ATOM   8862 C  CA  . SER D 2 238 ? -46.797 -25.369 44.754  1    61.64  ? 408 SER D CA  1 
ATOM   8863 C  C   . SER D 2 238 ? -47.969 -24.598 44.127  1    59.49  ? 408 SER D C   1 
ATOM   8864 O  O   . SER D 2 238 ? -48.723 -23.914 44.821  1    61.13  ? 408 SER D O   1 
ATOM   8865 C  CB  . SER D 2 238 ? -45.54  -24.532 44.76   1    58.68  ? 408 SER D CB  1 
ATOM   8866 O  OG  . SER D 2 238 ? -44.468 -25.185 45.428  1    58.03  ? 408 SER D OG  1 
ATOM   8867 N  N   . ILE D 2 239 ? -48.144 -24.738 42.811  1    59.64  ? 409 ILE D N   1 
ATOM   8868 C  CA  . ILE D 2 239 ? -49.2   -24.045 42.095  1    59.07  ? 409 ILE D CA  1 
ATOM   8869 C  C   . ILE D 2 239 ? -50.552 -24.677 42.435  1    65.93  ? 409 ILE D C   1 
ATOM   8870 O  O   . ILE D 2 239 ? -51.555 -23.965 42.517  1    70.5   ? 409 ILE D O   1 
ATOM   8871 C  CB  . ILE D 2 239 ? -48.903 -23.965 40.583  1    54.77  ? 409 ILE D CB  1 
ATOM   8872 C  CG1 . ILE D 2 239 ? -47.592 -23.254 40.278  1    53.22  ? 409 ILE D CG1 1 
ATOM   8873 C  CG2 . ILE D 2 239 ? -50.018 -23.261 39.842  1    53.42  ? 409 ILE D CG2 1 
ATOM   8874 C  CD1 . ILE D 2 239 ? -47.122 -23.39  38.838  1    48.06  ? 409 ILE D CD1 1 
ATOM   8875 N  N   . ARG D 2 240 ? -50.58  -25.991 42.683  1    66.24  ? 410 ARG D N   1 
ATOM   8876 C  CA  . ARG D 2 240 ? -51.807 -26.678 43.085  1    67.98  ? 410 ARG D CA  1 
ATOM   8877 C  C   . ARG D 2 240 ? -52.217 -26.261 44.501  1    68.89  ? 410 ARG D C   1 
ATOM   8878 O  O   . ARG D 2 240 ? -53.406 -26.067 44.772  1    70.28  ? 410 ARG D O   1 
ATOM   8879 C  CB  . ARG D 2 240 ? -51.673 -28.203 42.955  1    68.34  ? 410 ARG D CB  1 
ATOM   8880 C  CG  . ARG D 2 240 ? -51.856 -28.716 41.533  1    67.48  ? 410 ARG D CG  1 
ATOM   8881 C  CD  . ARG D 2 240 ? -52.061 -30.227 41.38   1    71.45  ? 410 ARG D CD  1 
ATOM   8882 N  NE  . ARG D 2 240 ? -53.359 -30.713 41.87   1    73.93  ? 410 ARG D NE  1 
ATOM   8883 C  CZ  . ARG D 2 240 ? -53.554 -31.471 42.95   1    74.04  ? 410 ARG D CZ  1 
ATOM   8884 N  NH1 . ARG D 2 240 ? -54.774 -31.79  43.315  1    73.69  ? 410 ARG D NH1 1 
ATOM   8885 N  NH2 . ARG D 2 240 ? -52.545 -31.892 43.684  1    73.06  ? 410 ARG D NH2 1 
ATOM   8886 N  N   . GLU D 2 241 ? -51.23  -26.138 45.399  1    69.16  ? 411 GLU D N   1 
ATOM   8887 C  CA  . GLU D 2 241 ? -51.46  -25.698 46.772  1    70.34  ? 411 GLU D CA  1 
ATOM   8888 C  C   . GLU D 2 241 ? -51.938 -24.248 46.77   1    72.84  ? 411 GLU D C   1 
ATOM   8889 O  O   . GLU D 2 241 ? -52.858 -23.904 47.514  1    77.24  ? 411 GLU D O   1 
ATOM   8890 C  CB  . GLU D 2 241 ? -50.206 -25.692 47.643  1    68.84  ? 411 GLU D CB  1 
ATOM   8891 C  CG  . GLU D 2 241 ? -49.444 -27.008 47.666  1    82.27  ? 411 GLU D CG  1 
ATOM   8892 C  CD  . GLU D 2 241 ? -50.176 -28.178 48.31   1    98.04  ? 411 GLU D CD  1 
ATOM   8893 O  OE1 . GLU D 2 241 ? -51.437 -28.224 48.387  1    91.87  ? 411 GLU D OE1 1 
ATOM   8894 O  OE2 . GLU D 2 241 ? -49.416 -29.076 48.707  1    112.41 ? 411 GLU D OE2 1 
ATOM   8895 N  N   . LYS D 2 242 ? -51.306 -23.417 45.924  1    66.48  ? 412 LYS D N   1 
ATOM   8896 C  CA  . LYS D 2 242 ? -51.601 -21.997 45.874  1    65.58  ? 412 LYS D CA  1 
ATOM   8897 C  C   . LYS D 2 242 ? -53.087 -21.814 45.569  1    68.79  ? 412 LYS D C   1 
ATOM   8898 O  O   . LYS D 2 242 ? -53.793 -21.139 46.326  1    72.97  ? 412 LYS D O   1 
ATOM   8899 C  CB  . LYS D 2 242 ? -50.654 -21.34  44.861  1    58.98  ? 412 LYS D CB  1 
ATOM   8900 C  CG  . LYS D 2 242 ? -51.004 -19.914 44.443  1    53.34  ? 412 LYS D CG  1 
ATOM   8901 C  CD  . LYS D 2 242 ? -49.928 -19.318 43.542  1    51.14  ? 412 LYS D CD  1 
ATOM   8902 C  CE  . LYS D 2 242 ? -50.223 -17.926 43.031  1    48.13  ? 412 LYS D CE  1 
ATOM   8903 N  NZ  . LYS D 2 242 ? -49.15  -17.502 42.139  1    42.43  ? 412 LYS D NZ  1 
ATOM   8904 N  N   . TYR D 2 243 ? -53.54  -22.498 44.5    1    66.06  ? 413 TYR D N   1 
ATOM   8905 C  CA  . TYR D 2 243 ? -54.868 -22.33  43.922  1    66.12  ? 413 TYR D CA  1 
ATOM   8906 C  C   . TYR D 2 243 ? -55.903 -23.232 44.612  1    70.56  ? 413 TYR D C   1 
ATOM   8907 O  O   . TYR D 2 243 ? -56.992 -23.449 44.082  1    69.15  ? 413 TYR D O   1 
ATOM   8908 C  CB  . TYR D 2 243 ? -54.82  -22.517 42.4    1    62.78  ? 413 TYR D CB  1 
ATOM   8909 C  CG  . TYR D 2 243 ? -54.257 -21.326 41.64   1    64.49  ? 413 TYR D CG  1 
ATOM   8910 C  CD1 . TYR D 2 243 ? -52.87  -21.106 41.565  1    63.32  ? 413 TYR D CD1 1 
ATOM   8911 C  CD2 . TYR D 2 243 ? -55.1   -20.41  41.01   1    63.12  ? 413 TYR D CD2 1 
ATOM   8912 C  CE1 . TYR D 2 243 ? -52.34  -20.033 40.865  1    57.45  ? 413 TYR D CE1 1 
ATOM   8913 C  CE2 . TYR D 2 243 ? -54.579 -19.324 40.32   1    61.14  ? 413 TYR D CE2 1 
ATOM   8914 C  CZ  . TYR D 2 243 ? -53.202 -19.149 40.241  1    60.06  ? 413 TYR D CZ  1 
ATOM   8915 O  OH  . TYR D 2 243 ? -52.704 -18.078 39.57   1    63.66  ? 413 TYR D OH  1 
ATOM   8916 N  N   . LYS D 2 244 ? -55.602 -23.695 45.828  1    72.59  ? 414 LYS D N   1 
ATOM   8917 C  CA  . LYS D 2 244 ? -56.596 -24.389 46.629  1    77.97  ? 414 LYS D CA  1 
ATOM   8918 C  C   . LYS D 2 244 ? -57.344 -23.412 47.526  1    80.08  ? 414 LYS D C   1 
ATOM   8919 O  O   . LYS D 2 244 ? -58.462 -23.719 47.943  1    81.93  ? 414 LYS D O   1 
ATOM   8920 C  CB  . LYS D 2 244 ? -55.968 -25.461 47.522  1    80.28  ? 414 LYS D CB  1 
ATOM   8921 C  CG  . LYS D 2 244 ? -55.751 -26.807 46.861  1    89.48  ? 414 LYS D CG  1 
ATOM   8922 C  CD  . LYS D 2 244 ? -54.732 -27.654 47.615  1    98.18  ? 414 LYS D CD  1 
ATOM   8923 C  CE  . LYS D 2 244 ? -54.526 -29.012 46.998  1    98.11  ? 414 LYS D CE  1 
ATOM   8924 N  NZ  . LYS D 2 244 ? -53.808 -29.921 47.894  1    97.2   ? 414 LYS D NZ  1 
ATOM   8925 N  N   A ASN D 2 245 ? -56.714 -22.266 47.833  0.5  79.35  ? 415 ASN D N   1 
ATOM   8926 N  N   B ASN D 2 245 ? -56.736 -22.247 47.784  0.5  79.16  ? 415 ASN D N   1 
ATOM   8927 C  CA  A ASN D 2 245 ? -57.282 -21.307 48.775  0.5  85.26  ? 415 ASN D CA  1 
ATOM   8928 C  CA  B ASN D 2 245 ? -57.268 -21.298 48.752  0.5  85.01  ? 415 ASN D CA  1 
ATOM   8929 C  C   A ASN D 2 245 ? -58.486 -20.603 48.146  0.5  89.53  ? 415 ASN D C   1 
ATOM   8930 C  C   B ASN D 2 245 ? -58.441 -20.522 48.147  0.5  89.79  ? 415 ASN D C   1 
ATOM   8931 O  O   A ASN D 2 245 ? -58.571 -20.479 46.921  0.5  90.48  ? 415 ASN D O   1 
ATOM   8932 O  O   B ASN D 2 245 ? -58.45  -20.242 46.943  0.5  90.9   ? 415 ASN D O   1 
ATOM   8933 C  CB  A ASN D 2 245 ? -56.264 -20.291 49.3    0.5  80.43  ? 415 ASN D CB  1 
ATOM   8934 C  CB  B ASN D 2 245 ? -56.192 -20.34  49.262  0.5  79.6   ? 415 ASN D CB  1 
ATOM   8935 C  CG  A ASN D 2 245 ? -56.892 -19.33  50.298  0.5  81.32  ? 415 ASN D CG  1 
ATOM   8936 C  CG  B ASN D 2 245 ? -54.817 -20.963 49.296  0.5  75.99  ? 415 ASN D CG  1 
ATOM   8937 O  OD1 A ASN D 2 245 ? -57.252 -18.199 49.942  0.5  76.1   ? 415 ASN D OD1 1 
ATOM   8938 O  OD1 B ASN D 2 245 ? -54.682 -22.165 49.54   0.5  77.23  ? 415 ASN D OD1 1 
ATOM   8939 N  ND2 A ASN D 2 245 ? -57.105 -19.775 51.531  0.5  82.35  ? 415 ASN D ND2 1 
ATOM   8940 N  ND2 B ASN D 2 245 ? -53.79  -20.173 49.025  0.5  73.5   ? 415 ASN D ND2 1 
ATOM   8941 N  N   . SER D 2 246 ? -59.397 -20.135 49.009  1    90.71  ? 416 SER D N   1 
ATOM   8942 C  CA  . SER D 2 246 ? -60.558 -19.347 48.614  1    92.69  ? 416 SER D CA  1 
ATOM   8943 C  C   . SER D 2 246 ? -60.186 -18.169 47.71   1    87.98  ? 416 SER D C   1 
ATOM   8944 O  O   . SER D 2 246 ? -60.898 -17.913 46.747  1    91.94  ? 416 SER D O   1 
ATOM   8945 C  CB  . SER D 2 246 ? -61.361 -18.893 49.805  1    90.72  ? 416 SER D CB  1 
ATOM   8946 O  OG  . SER D 2 246 ? -60.496 -18.556 50.878  1    97.99  ? 416 SER D OG  1 
ATOM   8947 N  N   . LYS D 2 247 ? -59.087 -17.464 48.013  1    82.15  ? 417 LYS D N   1 
ATOM   8948 C  CA  . LYS D 2 247 ? -58.614 -16.388 47.154  1    77.05  ? 417 LYS D CA  1 
ATOM   8949 C  C   . LYS D 2 247 ? -58.781 -16.757 45.675  1    78.1   ? 417 LYS D C   1 
ATOM   8950 O  O   . LYS D 2 247 ? -59.208 -15.912 44.895  1    76.59  ? 417 LYS D O   1 
ATOM   8951 C  CB  . LYS D 2 247 ? -57.171 -16.011 47.509  1    73.6   ? 417 LYS D CB  1 
ATOM   8952 C  CG  . LYS D 2 247 ? -56.351 -15.416 46.348  1    79.94  ? 417 LYS D CG  1 
ATOM   8953 C  CD  . LYS D 2 247 ? -54.881 -15.207 46.698  1    85.1   ? 417 LYS D CD  1 
ATOM   8954 C  CE  . LYS D 2 247 ? -54.556 -14.449 47.943  1    88.16  ? 417 LYS D CE  1 
ATOM   8955 N  NZ  . LYS D 2 247 ? -54.246 -13.068 47.562  1    91.8   ? 417 LYS D NZ  1 
ATOM   8956 N  N   . TYR D 2 248 ? -58.457 -18.01  45.296  1    79.18  ? 418 TYR D N   1 
ATOM   8957 C  CA  . TYR D 2 248 ? -58.535 -18.469 43.911  1    77.14  ? 418 TYR D CA  1 
ATOM   8958 C  C   . TYR D 2 248 ? -59.737 -19.394 43.691  1    79.49  ? 418 TYR D C   1 
ATOM   8959 O  O   . TYR D 2 248 ? -59.79  -20.09  42.675  1    79.54  ? 418 TYR D O   1 
ATOM   8960 C  CB  . TYR D 2 248 ? -57.226 -19.133 43.466  1    71.54  ? 418 TYR D CB  1 
ATOM   8961 C  CG  . TYR D 2 248 ? -56.017 -18.217 43.564  1    69.61  ? 418 TYR D CG  1 
ATOM   8962 C  CD1 . TYR D 2 248 ? -55.942 -17.068 42.783  1    66.28  ? 418 TYR D CD1 1 
ATOM   8963 C  CD2 . TYR D 2 248 ? -54.968 -18.491 44.448  1    68.35  ? 418 TYR D CD2 1 
ATOM   8964 C  CE1 . TYR D 2 248 ? -54.853 -16.213 42.874  1    67.2   ? 418 TYR D CE1 1 
ATOM   8965 C  CE2 . TYR D 2 248 ? -53.888 -17.626 44.561  1    65.06  ? 418 TYR D CE2 1 
ATOM   8966 C  CZ  . TYR D 2 248 ? -53.82  -16.484 43.766  1    66.81  ? 418 TYR D CZ  1 
ATOM   8967 O  OH  . TYR D 2 248 ? -52.75  -15.613 43.84   1    59.82  ? 418 TYR D OH  1 
ATOM   8968 N  N   . HIS D 2 249 ? -60.697 -19.382 44.625  1    79.62  ? 419 HIS D N   1 
ATOM   8969 C  CA  . HIS D 2 249 ? -61.955 -20.119 44.521  1    85.33  ? 419 HIS D CA  1 
ATOM   8970 C  C   . HIS D 2 249 ? -61.697 -21.622 44.472  1    84.39  ? 419 HIS D C   1 
ATOM   8971 O  O   . HIS D 2 249 ? -62.412 -22.338 43.778  1    87.3   ? 419 HIS D O   1 
ATOM   8972 C  CB  . HIS D 2 249 ? -62.814 -19.63  43.338  1    85.61  ? 419 HIS D CB  1 
ATOM   8973 C  CG  . HIS D 2 249 ? -62.943 -18.139 43.275  1    90.06  ? 419 HIS D CG  1 
ATOM   8974 N  ND1 . HIS D 2 249 ? -62.065 -17.329 42.58   1    92.31  ? 419 HIS D ND1 1 
ATOM   8975 C  CD2 . HIS D 2 249 ? -63.844 -17.306 43.842  1    89.68  ? 419 HIS D CD2 1 
ATOM   8976 C  CE1 . HIS D 2 249 ? -62.442 -16.057 42.712  1    87.93  ? 419 HIS D CE1 1 
ATOM   8977 N  NE2 . HIS D 2 249 ? -63.511 -16.022 43.482  1    88.09  ? 419 HIS D NE2 1 
ATOM   8978 N  N   . GLY D 2 250 ? -60.635 -22.072 45.155  1    82.16  ? 420 GLY D N   1 
ATOM   8979 C  CA  . GLY D 2 250 ? -60.225 -23.471 45.189  1    80.95  ? 420 GLY D CA  1 
ATOM   8980 C  C   . GLY D 2 250 ? -60.257 -24.177 43.828  1    78.73  ? 420 GLY D C   1 
ATOM   8981 O  O   . GLY D 2 250 ? -60.544 -25.374 43.787  1    85.14  ? 420 GLY D O   1 
ATOM   8982 N  N   . VAL D 2 251 ? -59.914 -23.47  42.74   1    70.75  ? 421 VAL D N   1 
ATOM   8983 C  CA  . VAL D 2 251 ? -60.078 -23.976 41.382  1    70.22  ? 421 VAL D CA  1 
ATOM   8984 C  C   . VAL D 2 251 ? -59.214 -25.211 41.113  1    73.61  ? 421 VAL D C   1 
ATOM   8985 O  O   . VAL D 2 251 ? -59.543 -25.992 40.212  1    78.63  ? 421 VAL D O   1 
ATOM   8986 C  CB  . VAL D 2 251 ? -59.882 -22.942 40.254  1    67.77  ? 421 VAL D CB  1 
ATOM   8987 C  CG1 . VAL D 2 251 ? -61.026 -21.932 40.194  1    66.68  ? 421 VAL D CG1 1 
ATOM   8988 C  CG2 . VAL D 2 251 ? -58.526 -22.247 40.343  1    61.93  ? 421 VAL D CG2 1 
ATOM   8989 N  N   . SER D 2 252 ? -58.108 -25.372 41.858  1    73.65  ? 422 SER D N   1 
ATOM   8990 C  CA  . SER D 2 252 ? -57.199 -26.499 41.656  1    74.72  ? 422 SER D CA  1 
ATOM   8991 C  C   . SER D 2 252 ? -57.822 -27.807 42.143  1    76.48  ? 422 SER D C   1 
ATOM   8992 O  O   . SER D 2 252 ? -57.348 -28.876 41.793  1    77.69  ? 422 SER D O   1 
ATOM   8993 C  CB  . SER D 2 252 ? -55.799 -26.272 42.232  1    72.84  ? 422 SER D CB  1 
ATOM   8994 O  OG  . SER D 2 252 ? -55.795 -26.197 43.652  1    79.55  ? 422 SER D OG  1 
ATOM   8995 N  N   . LEU D 2 253 ? -58.897 -27.718 42.927  1    79.47  ? 423 LEU D N   1 
ATOM   8996 C  CA  . LEU D 2 253 ? -59.615 -28.887 43.412  1    85.12  ? 423 LEU D CA  1 
ATOM   8997 C  C   . LEU D 2 253 ? -60.644 -29.389 42.397  1    89.36  ? 423 LEU D C   1 
ATOM   8998 O  O   . LEU D 2 253 ? -61.099 -30.518 42.532  1    93.35  ? 423 LEU D O   1 
ATOM   8999 C  CB  . LEU D 2 253 ? -60.269 -28.569 44.757  1    85.59  ? 423 LEU D CB  1 
ATOM   9000 C  CG  . LEU D 2 253 ? -59.299 -28.314 45.919  1    84.97  ? 423 LEU D CG  1 
ATOM   9001 C  CD1 . LEU D 2 253 ? -59.984 -27.604 47.079  1    83.39  ? 423 LEU D CD1 1 
ATOM   9002 C  CD2 . LEU D 2 253 ? -58.628 -29.605 46.387  1    82.58  ? 423 LEU D CD2 1 
ATOM   9003 N  N   . LEU D 2 254 ? -61.024 -28.561 41.409  1    91.27  ? 424 LEU D N   1 
ATOM   9004 C  CA  . LEU D 2 254 ? -61.96  -28.965 40.362  1    91.16  ? 424 LEU D CA  1 
ATOM   9005 C  C   . LEU D 2 254 ? -61.395 -30.151 39.586  1    95.35  ? 424 LEU D C   1 
ATOM   9006 O  O   . LEU D 2 254 ? -60.187 -30.255 39.381  1    99.91  ? 424 LEU D O   1 
ATOM   9007 C  CB  . LEU D 2 254 ? -62.313 -27.847 39.383  1    88.6   ? 424 LEU D CB  1 
ATOM   9008 C  CG  . LEU D 2 254 ? -63.134 -26.664 39.905  1    91.36  ? 424 LEU D CG  1 
ATOM   9009 C  CD1 . LEU D 2 254 ? -63.452 -25.668 38.793  1    86.59  ? 424 LEU D CD1 1 
ATOM   9010 C  CD2 . LEU D 2 254 ? -64.388 -27.106 40.624  1    93.27  ? 424 LEU D CD2 1 
ATOM   9011 N  N   . ASN D 2 255 ? -62.29  -31.051 39.159  1    100.35 ? 425 ASN D N   1 
ATOM   9012 C  CA  . ASN D 2 255 ? -61.939 -32.156 38.282  1    102.08 ? 425 ASN D CA  1 
ATOM   9013 C  C   . ASN D 2 255 ? -61.811 -31.644 36.85   1    103.37 ? 425 ASN D C   1 
ATOM   9014 O  O   . ASN D 2 255 ? -62.725 -30.995 36.341  1    106.02 ? 425 ASN D O   1 
ATOM   9015 C  CB  . ASN D 2 255 ? -62.938 -33.303 38.392  1    104.88 ? 425 ASN D CB  1 
ATOM   9016 C  CG  . ASN D 2 255 ? -62.862 -33.947 39.752  1    108.63 ? 425 ASN D CG  1 
ATOM   9017 O  OD1 . ASN D 2 255 ? -63.898 -34.188 40.382  1    112.46 ? 425 ASN D OD1 1 
ATOM   9018 N  ND2 . ASN D 2 255 ? -61.645 -34.21  40.212  1    108.01 ? 425 ASN D ND2 1 
ATOM   9019 N  N   . PRO D 2 256 ? -60.678 -31.935 36.164  1    94.15  ? 426 PRO D N   1 
ATOM   9020 C  CA  . PRO D 2 256 ? -60.556 -31.627 34.739  1    88.21  ? 426 PRO D CA  1 
ATOM   9021 C  C   . PRO D 2 256 ? -61.535 -32.443 33.882  1    91.03  ? 426 PRO D C   1 
ATOM   9022 O  O   . PRO D 2 256 ? -61.817 -33.603 34.176  1    88.9   ? 426 PRO D O   1 
ATOM   9023 C  CB  . PRO D 2 256 ? -59.085 -31.974 34.445  1    85.49  ? 426 PRO D CB  1 
ATOM   9024 C  CG  . PRO D 2 256 ? -58.669 -32.965 35.522  1    87.36  ? 426 PRO D CG  1 
ATOM   9025 C  CD  . PRO D 2 256 ? -59.487 -32.593 36.736  1    90.3   ? 426 PRO D CD  1 
ATOM   9026 N  N   . PRO D 2 257 ? -62.057 -31.882 32.765  1    91.34  ? 427 PRO D N   1 
ATOM   9027 C  CA  . PRO D 2 257 ? -62.894 -32.65  31.837  1    91.91  ? 427 PRO D CA  1 
ATOM   9028 C  C   . PRO D 2 257 ? -62.026 -33.719 31.177  1    93.32  ? 427 PRO D C   1 
ATOM   9029 O  O   . PRO D 2 257 ? -60.838 -33.49  30.926  1    94.61  ? 427 PRO D O   1 
ATOM   9030 C  CB  . PRO D 2 257 ? -63.342 -31.583 30.815  1    93.98  ? 427 PRO D CB  1 
ATOM   9031 C  CG  . PRO D 2 257 ? -62.208 -30.534 30.844  1    91.74  ? 427 PRO D CG  1 
ATOM   9032 C  CD  . PRO D 2 257 ? -61.781 -30.507 32.302  1    88.58  ? 427 PRO D CD  1 
ATOM   9033 N  N   . GLU D 2 258 ? -62.62  -34.878 30.88   1    97.09  ? 428 GLU D N   1 
ATOM   9034 C  CA  . GLU D 2 258 ? -61.839 -35.995 30.372  1    96.22  ? 428 GLU D CA  1 
ATOM   9035 C  C   . GLU D 2 258 ? -61.6   -35.882 28.862  1    96.64  ? 428 GLU D C   1 
ATOM   9036 O  O   . GLU D 2 258 ? -60.644 -36.474 28.364  1    93.97  ? 428 GLU D O   1 
ATOM   9037 C  CB  . GLU D 2 258 ? -62.396 -37.333 30.85   1    98.4   ? 428 GLU D CB  1 
ATOM   9038 C  CG  . GLU D 2 258 ? -61.892 -37.746 32.233  1    96.81  ? 428 GLU D CG  1 
ATOM   9039 C  CD  . GLU D 2 258 ? -62.771 -38.782 32.953  1    101.62 ? 428 GLU D CD  1 
ATOM   9040 O  OE1 . GLU D 2 258 ? -63.121 -39.849 32.398  1    102.7  ? 428 GLU D OE1 1 
ATOM   9041 O  OE2 . GLU D 2 258 ? -63.144 -38.52  34.113  1    101.93 ? 428 GLU D OE2 1 
ATOM   9042 N  N   . THR D 2 259 ? -62.468 -35.158 28.133  1    97.68  ? 429 THR D N   1 
ATOM   9043 C  CA  . THR D 2 259 ? -62.229 -34.855 26.72   1    102.96 ? 429 THR D CA  1 
ATOM   9044 C  C   . THR D 2 259 ? -62.67  -33.433 26.391  1    107.83 ? 429 THR D C   1 
ATOM   9045 O  O   . THR D 2 259 ? -63.546 -32.893 27.063  1    112.1  ? 429 THR D O   1 
ATOM   9046 C  CB  . THR D 2 259 ? -62.933 -35.784 25.729  1    107.15 ? 429 THR D CB  1 
ATOM   9047 O  OG1 . THR D 2 259 ? -64.322 -35.52  25.897  1    113.52 ? 429 THR D OG1 1 
ATOM   9048 C  CG2 . THR D 2 259 ? -62.563 -37.249 25.869  1    107.99 ? 429 THR D CG2 1 
ATOM   9049 N  N   . LEU D 2 260 ? -62.112 -32.891 25.296  1    108.84 ? 430 LEU D N   1 
ATOM   9050 C  CA  . LEU D 2 260 ? -62.369 -31.526 24.861  1    106.97 ? 430 LEU D CA  1 
ATOM   9051 C  C   . LEU D 2 260 ? -63.284 -31.487 23.643  1    115.59 ? 430 LEU D C   1 
ATOM   9052 O  O   . LEU D 2 260 ? -63.682 -30.395 23.239  1    118.59 ? 430 LEU D O   1 
ATOM   9053 C  CB  . LEU D 2 260 ? -61.043 -30.837 24.56   1    96.7   ? 430 LEU D CB  1 
ATOM   9054 C  CG  . LEU D 2 260 ? -60.059 -30.823 25.729  1    98.08  ? 430 LEU D CG  1 
ATOM   9055 C  CD1 . LEU D 2 260 ? -58.87  -29.955 25.412  1    105.91 ? 430 LEU D CD1 1 
ATOM   9056 C  CD2 . LEU D 2 260 ? -60.725 -30.357 27.011  1    97.38  ? 430 LEU D CD2 1 
ATOM   9057 N  N   . ASN D 2 261 ? -63.597 -32.657 23.064  1    116.39 ? 431 ASN D N   1 
ATOM   9058 C  CA  . ASN D 2 261 ? -64.555 -32.735 21.969  1    123.02 ? 431 ASN D CA  1 
ATOM   9059 C  C   . ASN D 2 261 ? -64.167 -31.769 20.84   1    127.48 ? 431 ASN D C   1 
ATOM   9060 O  O   . ASN D 2 261 ? -64.942 -30.853 20.528  1    124.15 ? 431 ASN D O   1 
ATOM   9061 C  CB  . ASN D 2 261 ? -65.961 -32.418 22.477  1    124.31 ? 431 ASN D CB  1 
ATOM   9062 C  CG  . ASN D 2 261 ? -67.036 -32.759 21.47   1    131.9  ? 431 ASN D CG  1 
ATOM   9063 O  OD1 . ASN D 2 261 ? -66.86  -33.699 20.693  1    140.57 ? 431 ASN D OD1 1 
ATOM   9064 N  ND2 . ASN D 2 261 ? -68.145 -32.03  21.466  1    132.14 ? 431 ASN D ND2 1 
ATOM   9065 N  N   . VAL D 2 262 ? -63.002 -32.001 20.216  1    130.62 ? 432 VAL D N   1 
ATOM   9066 C  CA  . VAL D 2 262 ? -62.408 -31.052 19.278  1    125.36 ? 432 VAL D CA  1 
ATOM   9067 C  C   . VAL D 2 262 ? -62.663 -31.479 17.821  1    122.83 ? 432 VAL D C   1 
ATOM   9068 O  O   . VAL D 2 262 ? -62.878 -32.685 17.594  1    123.83 ? 432 VAL D O   1 
ATOM   9069 C  CB  . VAL D 2 262 ? -60.904 -30.83  19.524  1    126.33 ? 432 VAL D CB  1 
ATOM   9070 C  CG1 . VAL D 2 262 ? -60.247 -29.93  18.469  1    111.45 ? 432 VAL D CG1 1 
ATOM   9071 C  CG2 . VAL D 2 262 ? -60.624 -30.36  20.952  1    128.48 ? 432 VAL D CG2 1 
HETATM 9072 C  C4  A IJU E 3 .   ? -8.494  -21.076 23.237  0.5  111.35 ? 301 IJU A C4  1 
HETATM 9073 C  C4  B IJU E 3 .   ? -8.103  -21.015 23.329  0.5  82.98  ? 301 IJU A C4  1 
HETATM 9074 C  C5  A IJU E 3 .   ? -7.758  -20.136 22.534  0.5  119.01 ? 301 IJU A C5  1 
HETATM 9075 C  C5  B IJU E 3 .   ? -9.194  -20.421 22.706  0.5  82.23  ? 301 IJU A C5  1 
HETATM 9076 C  C6  A IJU E 3 .   ? -6.373  -20.219 22.489  0.5  96.75  ? 301 IJU A C6  1 
HETATM 9077 C  C6  B IJU E 3 .   ? -10.479 -20.891 22.936  0.5  63.02  ? 301 IJU A C6  1 
HETATM 9078 C  C7  A IJU E 3 .   ? -5.793  -21.296 23.134  0.5  94.45  ? 301 IJU A C7  1 
HETATM 9079 C  C7  B IJU E 3 .   ? -10.607 -21.979 23.773  0.5  59.24  ? 301 IJU A C7  1 
HETATM 9080 N  N1  A IJU E 3 .   ? -6.497  -22.223 23.819  0.5  99.34  ? 301 IJU A N1  1 
HETATM 9081 N  N1  B IJU E 3 .   ? -9.561  -22.574 24.388  0.5  63.95  ? 301 IJU A N1  1 
HETATM 9082 C  C3  A IJU E 3 .   ? -7.841  -22.132 23.862  0.5  91.86  ? 301 IJU A C3  1 
HETATM 9083 C  C3  B IJU E 3 .   ? -8.32   -22.104 24.169  0.5  73.26  ? 301 IJU A C3  1 
HETATM 9084 C  C1  A IJU E 3 .   ? -10.887 -22.835 23.945  0.5  58.29  ? 301 IJU A C1  1 
HETATM 9085 C  C1  B IJU E 3 .   ? -4.981  -22.221 24.51   0.5  80.27  ? 301 IJU A C1  1 
HETATM 9086 O  O1  A IJU E 3 .   ? -9.921  -22.768 24.986  0.5  60.52  ? 301 IJU A O1  1 
HETATM 9087 O  O1  B IJU E 3 .   ? -6.05   -23.074 24.12   0.5  81.79  ? 301 IJU A O1  1 
HETATM 9088 C  C2  A IJU E 3 .   ? -8.615  -23.191 24.618  0.5  70.29  ? 301 IJU A C2  1 
HETATM 9089 C  C2  B IJU E 3 .   ? -7.21   -22.818 24.902  0.5  74.85  ? 301 IJU A C2  1 
HETATM 9090 BR BR1 A IJU E 3 .   ? -8.68   -18.741 21.632  0.5  181.81 ? 301 IJU A BR1 1 
HETATM 9091 BR BR1 B IJU E 3 .   ? -8.933  -19.007 21.472  0.5  116.14 ? 301 IJU A BR1 1 
HETATM 9092 C  C4  B IJU F 3 .   ? -33.69  14.941  28.878  0.12 34.17  ? 301 IJU C C4  1 
HETATM 9093 C  C4  C IJU F 3 .   ? -32.542 16.903  30.25   0.38 43.33  ? 301 IJU C C4  1 
HETATM 9094 C  C4  D IJU F 3 .   ? -30.467 22.876  29.438  0.5  78.3   ? 301 IJU C C4  1 
HETATM 9095 C  C5  B IJU F 3 .   ? -32.677 15.823  29.182  0.12 35.72  ? 301 IJU C C5  1 
HETATM 9096 C  C5  C IJU F 3 .   ? -32.589 15.747  29.5    0.38 46.93  ? 301 IJU C C5  1 
HETATM 9097 C  C5  D IJU F 3 .   ? -29.531 23.727  29.989  0.5  84.25  ? 301 IJU C C5  1 
HETATM 9098 C  C6  B IJU F 3 .   ? -31.885 15.615  30.298  0.12 35.86  ? 301 IJU C C6  1 
HETATM 9099 C  C6  C IJU F 3 .   ? -32.537 15.802  28.115  0.38 40.55  ? 301 IJU C C6  1 
HETATM 9100 C  C6  D IJU F 3 .   ? -29.778 24.382  31.185  0.5  82.88  ? 301 IJU C C6  1 
HETATM 9101 C  C7  B IJU F 3 .   ? -32.139 14.493  31.054  0.12 34.98  ? 301 IJU C C7  1 
HETATM 9102 C  C7  C IJU F 3 .   ? -32.427 17.053  27.546  0.38 41.78  ? 301 IJU C C7  1 
HETATM 9103 C  C7  D IJU F 3 .   ? -30.989 24.148  31.779  0.5  83.74  ? 301 IJU C C7  1 
HETATM 9104 N  N1  B IJU F 3 .   ? -33.122 13.618  30.777  0.12 34.07  ? 301 IJU C N1  1 
HETATM 9105 N  N1  C IJU F 3 .   ? -32.377 18.195  28.258  0.38 41.97  ? 301 IJU C N1  1 
HETATM 9106 N  N1  D IJU F 3 .   ? -31.922 23.325  31.259  0.5  88.71  ? 301 IJU C N1  1 
HETATM 9107 C  C3  B IJU F 3 .   ? -33.893 13.842  29.701  0.12 32.81  ? 301 IJU C C3  1 
HETATM 9108 C  C3  C IJU F 3 .   ? -32.444 18.114  29.594  0.38 43.31  ? 301 IJU C C3  1 
HETATM 9109 C  C3  D IJU F 3 .   ? -31.666 22.689  30.105  0.5  79.54  ? 301 IJU C C3  1 
HETATM 9110 C  C1  B IJU F 3 .   ? -36.275 11.095  30.201  0.12 29.25  ? 301 IJU C C1  1 
HETATM 9111 C  C1  C IJU F 3 .   ? -33.475 21.481  30.637  0.38 56.4   ? 301 IJU C C1  1 
HETATM 9112 C  C1  D IJU F 3 .   ? -32.96  19.634  30.756  0.5  79.31  ? 301 IJU C C1  1 
HETATM 9113 O  O1  B IJU F 3 .   ? -35.441 12.18   30.588  0.12 29.3   ? 301 IJU C O1  1 
HETATM 9114 O  O1  C IJU F 3 .   ? -33.346 20.286  29.84   0.38 55.1   ? 301 IJU C O1  1 
HETATM 9115 O  O1  D IJU F 3 .   ? -33.303 21.026  30.708  0.5  84.13  ? 301 IJU C O1  1 
HETATM 9116 C  C2  B IJU F 3 .   ? -34.982 12.84   29.436  0.12 30.81  ? 301 IJU C C2  1 
HETATM 9117 C  C2  C IJU F 3 .   ? -32.395 19.396  30.367  0.38 49.09  ? 301 IJU C C2  1 
HETATM 9118 C  C2  D IJU F 3 .   ? -32.748 21.763  29.611  0.5  80.19  ? 301 IJU C C2  1 
HETATM 9119 BR BR1 B IJU F 3 .   ? -32.373 17.338  28.089  0.12 38.4   ? 301 IJU C BR1 1 
HETATM 9120 BR BR1 C IJU F 3 .   ? -32.766 14.078  30.379  0.38 62.58  ? 301 IJU C BR1 1 
HETATM 9121 BR BR1 D IJU F 3 .   ? -27.886 24.013  29.101  0.5  97.55  ? 301 IJU C BR1 1 
HETATM 9122 O  O   . HOH G 4 .   ? -20.283 -47.426 15.101  1    65.83  ? 401 HOH A O   1 
HETATM 9123 O  O   . HOH G 4 .   ? 13.593  -32.159 -2.209  1    51.43  ? 402 HOH A O   1 
HETATM 9124 O  O   . HOH G 4 .   ? 4.966   -19.654 -4.999  1    51.08  ? 403 HOH A O   1 
HETATM 9125 O  O   . HOH G 4 .   ? 0.83    4.9     10.463  1    82.18  ? 404 HOH A O   1 
HETATM 9126 O  O   . HOH G 4 .   ? -0.686  -24.914 -18.929 1    61.34  ? 405 HOH A O   1 
HETATM 9127 O  O   . HOH G 4 .   ? -7.075  -12.984 8.222   1    41.2   ? 406 HOH A O   1 
HETATM 9128 O  O   . HOH G 4 .   ? -1.956  -24.2   8.823   1    56.63  ? 407 HOH A O   1 
HETATM 9129 O  O   . HOH G 4 .   ? -12.203 -12.683 -9.017  1    48.99  ? 408 HOH A O   1 
HETATM 9130 O  O   . HOH G 4 .   ? -21.979 -17.804 31.55   1    36.16  ? 409 HOH A O   1 
HETATM 9131 O  O   . HOH G 4 .   ? -20.039 -14.91  42.624  1    49.19  ? 410 HOH A O   1 
HETATM 9132 O  O   . HOH G 4 .   ? -14.893 -12.011 -5.142  1    35.48  ? 411 HOH A O   1 
HETATM 9133 O  O   . HOH G 4 .   ? -16.997 -22.368 27.885  1    53.04  ? 412 HOH A O   1 
HETATM 9134 O  O   . HOH G 4 .   ? -13.573 -11.596 -3.034  1    36.72  ? 413 HOH A O   1 
HETATM 9135 O  O   . HOH G 4 .   ? 0.858   -0.692  17.045  1    64.22  ? 414 HOH A O   1 
HETATM 9136 O  O   . HOH G 4 .   ? 8.928   -31.4   -14.721 1    66.9   ? 415 HOH A O   1 
HETATM 9137 O  O   . HOH G 4 .   ? 15.208  -31.395 -14.187 1    48.49  ? 416 HOH A O   1 
HETATM 9138 O  O   . HOH G 4 .   ? 2.105   -15.501 -8.225  1    55.62  ? 417 HOH A O   1 
HETATM 9139 O  O   . HOH G 4 .   ? -6.685  -12.51  16.424  1    66.71  ? 418 HOH A O   1 
HETATM 9140 O  O   . HOH G 4 .   ? -7.118  -8.698  -4.536  1    81.17  ? 419 HOH A O   1 
HETATM 9141 O  O   . HOH G 4 .   ? -7.71   -16.626 -4.026  1    44.29  ? 420 HOH A O   1 
HETATM 9142 O  O   . HOH G 4 .   ? 0.024   -27.544 20.979  1    55.33  ? 421 HOH A O   1 
HETATM 9143 O  O   . HOH G 4 .   ? -9.584  -52.012 3.095   1    54.4   ? 422 HOH A O   1 
HETATM 9144 O  O   . HOH G 4 .   ? 2.104   -29.629 13.211  1    51.96  ? 423 HOH A O   1 
HETATM 9145 O  O   . HOH G 4 .   ? -26.445 -27.565 0.083   1    63.25  ? 424 HOH A O   1 
HETATM 9146 O  O   . HOH G 4 .   ? -12.545 -10.24  2.93    1    40.47  ? 425 HOH A O   1 
HETATM 9147 O  O   . HOH G 4 .   ? -1.663  -8.96   22.614  1    61.44  ? 426 HOH A O   1 
HETATM 9148 O  O   . HOH G 4 .   ? -1.312  -17.619 -3.428  1    41.71  ? 427 HOH A O   1 
HETATM 9149 O  O   . HOH G 4 .   ? 1.867   -32.442 6.203   1    37.39  ? 428 HOH A O   1 
HETATM 9150 O  O   . HOH G 4 .   ? -22.247 -18.831 27.623  1    53.45  ? 429 HOH A O   1 
HETATM 9151 O  O   . HOH G 4 .   ? -21.655 -40.342 6.139   1    64.92  ? 430 HOH A O   1 
HETATM 9152 O  O   . HOH G 4 .   ? -19.595 -21.576 17.266  1    44.8   ? 431 HOH A O   1 
HETATM 9153 O  O   . HOH G 4 .   ? 5.275   -32.091 -14.654 1    55.83  ? 432 HOH A O   1 
HETATM 9154 O  O   . HOH G 4 .   ? -7.875  -23.849 -4.169  1    35.46  ? 433 HOH A O   1 
HETATM 9155 O  O   . HOH G 4 .   ? 0.223   -33.588 8.222   1    35.14  ? 434 HOH A O   1 
HETATM 9156 O  O   . HOH G 4 .   ? -3.343  -43.55  15.306  1    81.52  ? 435 HOH A O   1 
HETATM 9157 O  O   . HOH G 4 .   ? -14.351 -27.009 -1.386  1    32.63  ? 436 HOH A O   1 
HETATM 9158 O  O   . HOH G 4 .   ? -3.211  -36.374 -5.751  1    55.96  ? 437 HOH A O   1 
HETATM 9159 O  O   . HOH G 4 .   ? -22.842 -26.898 4.622   1    51.66  ? 438 HOH A O   1 
HETATM 9160 O  O   . HOH G 4 .   ? -16.44  -25.197 27.955  1    53.53  ? 439 HOH A O   1 
HETATM 9161 O  O   . HOH G 4 .   ? 5.667   -20.239 -14.914 1    63.79  ? 440 HOH A O   1 
HETATM 9162 O  O   . HOH G 4 .   ? 1.213   -38.594 7.931   1    47.01  ? 441 HOH A O   1 
HETATM 9163 O  O   . HOH G 4 .   ? -5.992  -24.419 6.161   1    35.68  ? 442 HOH A O   1 
HETATM 9164 O  O   . HOH G 4 .   ? -2.786  -20.026 -5.489  1    35.26  ? 443 HOH A O   1 
HETATM 9165 O  O   . HOH G 4 .   ? 1.187   -29.471 2.354   1    38.96  ? 444 HOH A O   1 
HETATM 9166 O  O   . HOH G 4 .   ? 2.232   -18.406 6.326   1    58.16  ? 445 HOH A O   1 
HETATM 9167 O  O   . HOH G 4 .   ? 5.322   -42.218 1.219   1    50.98  ? 446 HOH A O   1 
HETATM 9168 O  O   . HOH G 4 .   ? -14.352 -35.998 -4.842  1    72.19  ? 447 HOH A O   1 
HETATM 9169 O  O   . HOH G 4 .   ? -8.894  -48.732 16.076  1    65.77  ? 448 HOH A O   1 
HETATM 9170 O  O   . HOH G 4 .   ? -5.163  -15.666 -4.321  1    47.2   ? 449 HOH A O   1 
HETATM 9171 O  O   . HOH G 4 .   ? -7.586  -18.55  10.537  1    27.83  ? 450 HOH A O   1 
HETATM 9172 O  O   . HOH G 4 .   ? -3.43   -4.616  11.14   1    53.05  ? 451 HOH A O   1 
HETATM 9173 O  O   . HOH G 4 .   ? -1.943  -43.988 -7.595  1    55.61  ? 452 HOH A O   1 
HETATM 9174 O  O   . HOH G 4 .   ? -16.674 -43.638 14.989  1    59.18  ? 453 HOH A O   1 
HETATM 9175 O  O   . HOH G 4 .   ? -16.557 -18.247 41.486  1    89.12  ? 454 HOH A O   1 
HETATM 9176 O  O   . HOH G 4 .   ? -16.783 -38.748 -3.273  1    63.68  ? 455 HOH A O   1 
HETATM 9177 O  O   . HOH G 4 .   ? -19.852 -29.281 20.075  1    89.46  ? 456 HOH A O   1 
HETATM 9178 O  O   . HOH G 4 .   ? -10.453 -11.145 -10.107 1    45.43  ? 457 HOH A O   1 
HETATM 9179 O  O   . HOH G 4 .   ? -3.267  -5.732  7.536   1    54.8   ? 458 HOH A O   1 
HETATM 9180 O  O   . HOH G 4 .   ? -5.093  -42.745 -5.784  1    52.26  ? 459 HOH A O   1 
HETATM 9181 O  O   . HOH G 4 .   ? -18.393 -18.285 17.24   1    43.31  ? 460 HOH A O   1 
HETATM 9182 O  O   . HOH G 4 .   ? -8.225  -33.175 -13.074 1    54.01  ? 461 HOH A O   1 
HETATM 9183 O  O   . HOH G 4 .   ? -5.165  -10.811 16.757  1    64.17  ? 462 HOH A O   1 
HETATM 9184 O  O   . HOH G 4 .   ? 11.034  -21.235 1.482   1    56.63  ? 463 HOH A O   1 
HETATM 9185 O  O   . HOH G 4 .   ? -4.26   -51.448 6.147   1    62.33  ? 464 HOH A O   1 
HETATM 9186 O  O   . HOH G 4 .   ? -12.287 -10.855 5.412   1    37.3   ? 465 HOH A O   1 
HETATM 9187 O  O   . HOH G 4 .   ? -11.62  -16.819 -9.318  1    60.27  ? 466 HOH A O   1 
HETATM 9188 O  O   . HOH G 4 .   ? -8.321  -10.417 -8.039  1    46.53  ? 467 HOH A O   1 
HETATM 9189 O  O   . HOH G 4 .   ? -18.432 -38.394 -1.241  1    60.73  ? 468 HOH A O   1 
HETATM 9190 O  O   . HOH G 4 .   ? 9.327   -22.131 -7.98   1    63.64  ? 469 HOH A O   1 
HETATM 9191 O  O   . HOH G 4 .   ? -22.009 -28.41  8.124   1    44.51  ? 470 HOH A O   1 
HETATM 9192 O  O   . HOH G 4 .   ? -16.019 -23.2   37.363  1    52.77  ? 471 HOH A O   1 
HETATM 9193 O  O   . HOH G 4 .   ? 8.029   -44.382 -3.214  1    59.77  ? 472 HOH A O   1 
HETATM 9194 O  O   . HOH G 4 .   ? -4.297  -8.576  5.665   1    55.92  ? 473 HOH A O   1 
HETATM 9195 O  O   . HOH G 4 .   ? 0.309   -37.366 -10.11  1    35.79  ? 474 HOH A O   1 
HETATM 9196 O  O   . HOH G 4 .   ? 2.721   -20.35  10.082  1    54.53  ? 475 HOH A O   1 
HETATM 9197 O  O   . HOH G 4 .   ? -21.285 -42.4   5.258   1    54.3   ? 476 HOH A O   1 
HETATM 9198 O  O   . HOH G 4 .   ? -6.508  -25.12  26.676  1    61.73  ? 477 HOH A O   1 
HETATM 9199 O  O   . HOH G 4 .   ? 10.222  -36.909 0.536   1    48.78  ? 478 HOH A O   1 
HETATM 9200 O  O   . HOH G 4 .   ? -20.576 -35.845 16.677  1    57.23  ? 479 HOH A O   1 
HETATM 9201 O  O   . HOH G 4 .   ? -23.457 -29.49  10.436  1    39.42  ? 480 HOH A O   1 
HETATM 9202 O  O   . HOH G 4 .   ? -27.115 -20.104 8.119   1    52.13  ? 481 HOH A O   1 
HETATM 9203 O  O   . HOH G 4 .   ? -22.188 -36.078 22.096  1    77.92  ? 482 HOH A O   1 
HETATM 9204 O  O   . HOH G 4 .   ? 2.919   -54.073 -2.182  1    49.43  ? 483 HOH A O   1 
HETATM 9205 O  O   . HOH G 4 .   ? -9.762  -19.176 18.733  1    60.38  ? 484 HOH A O   1 
HETATM 9206 O  O   . HOH G 4 .   ? -21.63  -12.581 27.36   1    57.68  ? 485 HOH A O   1 
HETATM 9207 O  O   . HOH G 4 .   ? -1.143  -14.962 -5.981  1    63     ? 486 HOH A O   1 
HETATM 9208 O  O   . HOH G 4 .   ? 1.625   -50.913 2.489   1    64.1   ? 487 HOH A O   1 
HETATM 9209 O  O   . HOH G 4 .   ? -5.701  -23.072 19.37   1    63.74  ? 488 HOH A O   1 
HETATM 9210 O  O   . HOH G 4 .   ? -4.785  -19.513 -10.34  1    49.34  ? 489 HOH A O   1 
HETATM 9211 O  O   . HOH G 4 .   ? -8.233  -14.229 -14.2   1    53.86  ? 490 HOH A O   1 
HETATM 9212 O  O   . HOH G 4 .   ? -16.024 -41.887 -2.797  1    47.41  ? 491 HOH A O   1 
HETATM 9213 O  O   . HOH G 4 .   ? -4.69   -29.992 -19.841 1    67.43  ? 492 HOH A O   1 
HETATM 9214 O  O   . HOH G 4 .   ? -8.868  -12.2   37.866  1    54.43  ? 493 HOH A O   1 
HETATM 9215 O  O   . HOH G 4 .   ? -6.397  -25.162 -11.124 1    50.48  ? 494 HOH A O   1 
HETATM 9216 O  O   . HOH G 4 .   ? 12.001  -22.364 -1.326  1    48.79  ? 495 HOH A O   1 
HETATM 9217 O  O   . HOH G 4 .   ? -18.239 -24.254 31.817  1    42.72  ? 496 HOH A O   1 
HETATM 9218 O  O   . HOH G 4 .   ? -3.644  -52.031 8.823   1    62.96  ? 497 HOH A O   1 
HETATM 9219 O  O   . HOH G 4 .   ? 4.192   -41.178 3.422   1    53.63  ? 498 HOH A O   1 
HETATM 9220 O  O   . HOH G 4 .   ? -7.421  -47.678 9.469   1    60.27  ? 499 HOH A O   1 
HETATM 9221 O  O   . HOH G 4 .   ? -2.069  -7.635  20.403  1    55.16  ? 500 HOH A O   1 
HETATM 9222 O  O   . HOH G 4 .   ? -2.224  -8.719  8.778   1    66.82  ? 501 HOH A O   1 
HETATM 9223 O  O   . HOH G 4 .   ? -19.05  -38.029 15.935  1    67.83  ? 502 HOH A O   1 
HETATM 9224 O  O   . HOH G 4 .   ? 6.815   -19.668 2.95    1    52.4   ? 503 HOH A O   1 
HETATM 9225 O  O   . HOH G 4 .   ? -14.411 -34.347 -8.551  1    63.89  ? 504 HOH A O   1 
HETATM 9226 O  O   . HOH G 4 .   ? -2.741  -7.573  12.089  1    58.49  ? 505 HOH A O   1 
HETATM 9227 O  O   . HOH G 4 .   ? -4.349  -35.994 -8.204  1    40.68  ? 506 HOH A O   1 
HETATM 9228 O  O   . HOH G 4 .   ? -3.911  -24.56  21.947  1    73.47  ? 507 HOH A O   1 
HETATM 9229 O  O   . HOH G 4 .   ? -20.781 -37.273 -2.05   1    54.26  ? 508 HOH A O   1 
HETATM 9230 O  O   . HOH G 4 .   ? 13.744  -27.159 -9.85   1    53.52  ? 509 HOH A O   1 
HETATM 9231 O  O   . HOH G 4 .   ? -7.359  -51.466 6.671   1    62.29  ? 510 HOH A O   1 
HETATM 9232 O  O   . HOH G 4 .   ? 10.388  -41.625 -10.263 1    53.74  ? 511 HOH A O   1 
HETATM 9233 O  O   . HOH G 4 .   ? -15.829 -44.27  -2.211  1    49.38  ? 512 HOH A O   1 
HETATM 9234 O  O   . HOH G 4 .   ? -16.97  -51.066 5.677   1    78.79  ? 513 HOH A O   1 
HETATM 9235 O  O   . HOH G 4 .   ? -17.462 -4.338  26.629  1    68.18  ? 514 HOH A O   1 
HETATM 9236 O  O   . HOH G 4 .   ? -6.939  -19.498 19.436  1    74.65  ? 515 HOH A O   1 
HETATM 9237 O  O   . HOH G 4 .   ? -25.313 -21.862 4.552   1    84.31  ? 516 HOH A O   1 
HETATM 9238 O  O   . HOH G 4 .   ? -24.604 -27.365 10.117  1    49.07  ? 517 HOH A O   1 
HETATM 9239 O  O   . HOH G 4 .   ? -8.5    -23.925 -9.987  1    53.46  ? 518 HOH A O   1 
HETATM 9240 O  O   . HOH G 4 .   ? -6.914  -44.577 -3.442  1    54.5   ? 519 HOH A O   1 
HETATM 9241 O  O   . HOH G 4 .   ? -23.49  -4.665  24.588  1    73.21  ? 520 HOH A O   1 
HETATM 9242 O  O   . HOH G 4 .   ? 6.049   -40.523 13.947  1    64.47  ? 521 HOH A O   1 
HETATM 9243 O  O   . HOH G 4 .   ? -17.196 -36.161 -4.717  1    45.91  ? 522 HOH A O   1 
HETATM 9244 O  O   . HOH G 4 .   ? 3.710   -39.619 26.699  1    55.84  ? 523 HOH A O   1 
HETATM 9245 O  O   . HOH G 4 .   ? 3.705   -26.823 12.415  1    57.3   ? 524 HOH A O   1 
HETATM 9246 O  O   . HOH G 4 .   ? -22.116 -44.593 3.377   1    57.07  ? 525 HOH A O   1 
HETATM 9247 O  O   . HOH G 4 .   ? 6.21    -27.954 -19.14  1    81.39  ? 526 HOH A O   1 
HETATM 9248 O  O   . HOH G 4 .   ? -19.6   -14.436 28.396  1    49.11  ? 527 HOH A O   1 
HETATM 9249 O  O   . HOH G 4 .   ? -0.714  -13.309 -8.362  1    59.5   ? 528 HOH A O   1 
HETATM 9250 O  O   . HOH G 4 .   ? -1.668  -24.051 -22.822 1    65.81  ? 529 HOH A O   1 
HETATM 9251 O  O   . HOH G 4 .   ? 3.52    -6.785  20.996  1    60.19  ? 530 HOH A O   1 
HETATM 9252 O  O   . HOH G 4 .   ? -27.392 -21.811 11.016  1    52.46  ? 531 HOH A O   1 
HETATM 9253 O  O   . HOH H 4 .   ? -9.671  1.859   -9.524  1    61.57  ? 501 HOH B O   1 
HETATM 9254 O  O   . HOH H 4 .   ? -30.338 -21.543 -0.208  1    46.28  ? 502 HOH B O   1 
HETATM 9255 O  O   . HOH H 4 .   ? -26.089 2.559   13.803  1    57.46  ? 503 HOH B O   1 
HETATM 9256 O  O   . HOH H 4 .   ? -12.008 9.419   -9.856  1    49.24  ? 504 HOH B O   1 
HETATM 9257 O  O   . HOH H 4 .   ? -38.398 4.133   -9.241  1    52.31  ? 505 HOH B O   1 
HETATM 9258 O  O   . HOH H 4 .   ? -8.442  2.343   17.266  1    42.85  ? 506 HOH B O   1 
HETATM 9259 O  O   . HOH H 4 .   ? -30.506 16.309  7.042   1    47.27  ? 507 HOH B O   1 
HETATM 9260 O  O   . HOH H 4 .   ? -13.642 -10.861 -0.282  1    35.11  ? 508 HOH B O   1 
HETATM 9261 O  O   . HOH H 4 .   ? -19.574 -32.111 -4.93   1    51.86  ? 509 HOH B O   1 
HETATM 9262 O  O   . HOH H 4 .   ? -32.431 8.295   -10.006 1    60.1   ? 510 HOH B O   1 
HETATM 9263 O  O   . HOH H 4 .   ? -17.948 -0.873  -7.68   1    46.85  ? 511 HOH B O   1 
HETATM 9264 O  O   . HOH H 4 .   ? -34.745 -21.821 -8.716  1    65.84  ? 512 HOH B O   1 
HETATM 9265 O  O   . HOH H 4 .   ? -32.247 -10.108 0.849   1    47.94  ? 513 HOH B O   1 
HETATM 9266 O  O   . HOH H 4 .   ? -28.817 9.614   -8.477  1    44.26  ? 514 HOH B O   1 
HETATM 9267 O  O   . HOH H 4 .   ? -14.915 -24.289 -14.425 1    66.51  ? 515 HOH B O   1 
HETATM 9268 O  O   . HOH H 4 .   ? -34.579 -2.73   -20.437 1    69.76  ? 516 HOH B O   1 
HETATM 9269 O  O   . HOH H 4 .   ? -29.88  22.181  11.338  1    59.91  ? 517 HOH B O   1 
HETATM 9270 O  O   . HOH H 4 .   ? -15.336 -27.416 1.157   1    31.5   ? 518 HOH B O   1 
HETATM 9271 O  O   . HOH H 4 .   ? -16.964 -7.919  -4.114  1    45.17  ? 519 HOH B O   1 
HETATM 9272 O  O   . HOH H 4 .   ? -25.184 -5.104  3.741   1    59.22  ? 520 HOH B O   1 
HETATM 9273 O  O   . HOH H 4 .   ? -16.181 -8.239  1.737   1    31.63  ? 521 HOH B O   1 
HETATM 9274 O  O   . HOH H 4 .   ? -34.103 1.143   -25.75  1    60.84  ? 522 HOH B O   1 
HETATM 9275 O  O   . HOH H 4 .   ? -16.508 14.797  -8.263  1    46.99  ? 523 HOH B O   1 
HETATM 9276 O  O   . HOH H 4 .   ? -8.364  20.755  11.873  1    55.53  ? 524 HOH B O   1 
HETATM 9277 O  O   . HOH H 4 .   ? -21.452 4.875   -19.657 1    65.09  ? 525 HOH B O   1 
HETATM 9278 O  O   . HOH H 4 .   ? -5.637  -6.213  5.967   1    40.16  ? 526 HOH B O   1 
HETATM 9279 O  O   . HOH H 4 .   ? -15.126 -17.24  -13.231 1    52.33  ? 527 HOH B O   1 
HETATM 9280 O  O   . HOH H 4 .   ? -27.093 12.676  -3.265  1    65.01  ? 528 HOH B O   1 
HETATM 9281 O  O   . HOH H 4 .   ? -24.128 -4.382  14.149  1    55.39  ? 529 HOH B O   1 
HETATM 9282 O  O   . HOH H 4 .   ? 3.869   -8.91   -1.951  1    68.81  ? 530 HOH B O   1 
HETATM 9283 O  O   . HOH H 4 .   ? -25.892 11.125  -0.46   1    43.13  ? 531 HOH B O   1 
HETATM 9284 O  O   . HOH H 4 .   ? -10.643 -19.494 -12.075 1    61.05  ? 532 HOH B O   1 
HETATM 9285 O  O   . HOH H 4 .   ? -13.969 -21.595 -11.991 1    53.48  ? 533 HOH B O   1 
HETATM 9286 O  O   . HOH H 4 .   ? -23.61  20.273  0.634   1    54.77  ? 534 HOH B O   1 
HETATM 9287 O  O   . HOH H 4 .   ? -29.334 11.599  13.904  1    59.27  ? 535 HOH B O   1 
HETATM 9288 O  O   . HOH H 4 .   ? -3.965  -4.43   -0.782  1    48.68  ? 536 HOH B O   1 
HETATM 9289 O  O   . HOH H 4 .   ? -2.741  15.815  11.17   1    66.36  ? 537 HOH B O   1 
HETATM 9290 O  O   . HOH H 4 .   ? -25.803 4.066   18.732  1    40.58  ? 538 HOH B O   1 
HETATM 9291 O  O   . HOH H 4 .   ? -26.677 3.892   -26.2   1    65.93  ? 539 HOH B O   1 
HETATM 9292 O  O   . HOH H 4 .   ? -20.989 8.412   -17.8   1    35.47  ? 540 HOH B O   1 
HETATM 9293 O  O   . HOH H 4 .   ? -18.269 -8.496  3.592   1    36.58  ? 541 HOH B O   1 
HETATM 9294 O  O   . HOH H 4 .   ? -24.371 -17.633 -8.691  1    66.75  ? 542 HOH B O   1 
HETATM 9295 O  O   . HOH H 4 .   ? -33.733 -12.258 -20.667 1    77.07  ? 543 HOH B O   1 
HETATM 9296 O  O   . HOH H 4 .   ? -19.583 -13.01  -0.565  1    41.29  ? 544 HOH B O   1 
HETATM 9297 O  O   . HOH H 4 .   ? -21.392 22.159  12.246  1    51.28  ? 545 HOH B O   1 
HETATM 9298 O  O   . HOH H 4 .   ? -27.05  6.397   19.579  1    65.17  ? 546 HOH B O   1 
HETATM 9299 O  O   . HOH H 4 .   ? -28.866 17.23   0.385   1    56.92  ? 547 HOH B O   1 
HETATM 9300 O  O   . HOH H 4 .   ? -26.704 11.146  -11.985 1    54.05  ? 548 HOH B O   1 
HETATM 9301 O  O   . HOH H 4 .   ? -30.869 -19.53  -5.073  1    56.06  ? 549 HOH B O   1 
HETATM 9302 O  O   . HOH H 4 .   ? -12.208 3.973   -5.779  1    39.41  ? 550 HOH B O   1 
HETATM 9303 O  O   . HOH H 4 .   ? -20.205 -13.32  -3.463  1    42.19  ? 551 HOH B O   1 
HETATM 9304 O  O   . HOH H 4 .   ? -37.134 11.833  -16.25  1    61.55  ? 552 HOH B O   1 
HETATM 9305 O  O   . HOH H 4 .   ? -26.344 15.732  11.906  1    57.88  ? 553 HOH B O   1 
HETATM 9306 O  O   . HOH H 4 .   ? -25.82  1.721   -2.961  1    53.09  ? 554 HOH B O   1 
HETATM 9307 O  O   . HOH H 4 .   ? -37.474 -6.971  -6.412  1    54.27  ? 555 HOH B O   1 
HETATM 9308 O  O   . HOH H 4 .   ? -20.969 -12.556 8.988   1    47.37  ? 556 HOH B O   1 
HETATM 9309 O  O   . HOH H 4 .   ? -24.96  -24.364 -1.398  1    43.17  ? 557 HOH B O   1 
HETATM 9310 O  O   . HOH H 4 .   ? -24.259 9.49    -8.628  1    42.83  ? 558 HOH B O   1 
HETATM 9311 O  O   . HOH H 4 .   ? -16.017 16.587  7.72    1    49.85  ? 559 HOH B O   1 
HETATM 9312 O  O   . HOH H 4 .   ? -39.286 -16.429 -15.682 1    64.15  ? 560 HOH B O   1 
HETATM 9313 O  O   . HOH H 4 .   ? -31.686 10.202  2.411   1    60.05  ? 561 HOH B O   1 
HETATM 9314 O  O   . HOH H 4 .   ? -21.647 11.313  -12.049 1    51.46  ? 562 HOH B O   1 
HETATM 9315 O  O   . HOH H 4 .   ? -27.92  -18.357 -17.725 1    57.93  ? 563 HOH B O   1 
HETATM 9316 O  O   . HOH H 4 .   ? -6.072  -3.471  -3.951  1    40.12  ? 564 HOH B O   1 
HETATM 9317 O  O   . HOH H 4 .   ? -11.949 -22.707 -10.431 1    46.56  ? 565 HOH B O   1 
HETATM 9318 O  O   . HOH H 4 .   ? -19.026 10.196  -8.406  1    44.83  ? 566 HOH B O   1 
HETATM 9319 O  O   . HOH H 4 .   ? -30.427 -11.814 -4.837  1    45.9   ? 567 HOH B O   1 
HETATM 9320 O  O   . HOH H 4 .   ? -28.634 -23.656 -0.652  1    55.95  ? 568 HOH B O   1 
HETATM 9321 O  O   . HOH H 4 .   ? -32.819 -16.389 -3.4    1    52.91  ? 569 HOH B O   1 
HETATM 9322 O  O   . HOH H 4 .   ? -7.582  14.584  -0.122  1    58.83  ? 570 HOH B O   1 
HETATM 9323 O  O   . HOH H 4 .   ? -27.625 -3.819  3.297   1    54.14  ? 571 HOH B O   1 
HETATM 9324 O  O   . HOH H 4 .   ? -33.082 16.704  12.028  1    61.04  ? 572 HOH B O   1 
HETATM 9325 O  O   . HOH H 4 .   ? -21.631 10.89   -8.484  1    50.16  ? 573 HOH B O   1 
HETATM 9326 O  O   . HOH H 4 .   ? 0.443   11.686  8.147   1    55.57  ? 574 HOH B O   1 
HETATM 9327 O  O   . HOH H 4 .   ? -35.529 -4.028  2.563   1    60.47  ? 575 HOH B O   1 
HETATM 9328 O  O   . HOH H 4 .   ? -19.286 10.189  -11.198 1    49.39  ? 576 HOH B O   1 
HETATM 9329 O  O   . HOH H 4 .   ? -22.505 1.308   25.268  1    67.65  ? 577 HOH B O   1 
HETATM 9330 O  O   . HOH H 4 .   ? -37.883 -10.766 -15.614 1    46.04  ? 578 HOH B O   1 
HETATM 9331 O  O   . HOH H 4 .   ? -6.995  -20.76  -10.13  1    56.02  ? 579 HOH B O   1 
HETATM 9332 O  O   . HOH H 4 .   ? -21.473 -10.656 -25.43  1    51.83  ? 580 HOH B O   1 
HETATM 9333 O  O   . HOH H 4 .   ? -39.083 3.174   -4.805  1    62.82  ? 581 HOH B O   1 
HETATM 9334 O  O   . HOH H 4 .   ? -35.321 1.832   7.696   1    60.42  ? 582 HOH B O   1 
HETATM 9335 O  O   . HOH H 4 .   ? -25.508 1.471   1.889   1    71.56  ? 583 HOH B O   1 
HETATM 9336 O  O   . HOH H 4 .   ? -32.785 8.199   1.755   1    68.2   ? 584 HOH B O   1 
HETATM 9337 O  O   . HOH H 4 .   ? -22.874 -1.951  -1.704  1    42.82  ? 585 HOH B O   1 
HETATM 9338 O  O   . HOH H 4 .   ? -29.561 19.234  7.946   1    66.94  ? 586 HOH B O   1 
HETATM 9339 O  O   . HOH H 4 .   ? -40.511 -3.428  -6.08   1    62.38  ? 587 HOH B O   1 
HETATM 9340 O  O   . HOH H 4 .   ? -31.355 -17.998 -18.33  1    45.99  ? 588 HOH B O   1 
HETATM 9341 O  O   . HOH H 4 .   ? -18.146 -10.359 -24.816 1    67.8   ? 589 HOH B O   1 
HETATM 9342 O  O   . HOH H 4 .   ? -24.299 -24.327 -4.142  1    43.18  ? 590 HOH B O   1 
HETATM 9343 O  O   . HOH H 4 .   ? -37.04  -2.394  -7.271  1    43.97  ? 591 HOH B O   1 
HETATM 9344 O  O   . HOH H 4 .   ? -18.931 21.11   12.677  1    49.26  ? 592 HOH B O   1 
HETATM 9345 O  O   . HOH H 4 .   ? -30.187 -20.862 -11.936 1    65.6   ? 593 HOH B O   1 
HETATM 9346 O  O   . HOH H 4 .   ? -13.139 -5.328  -5.451  1    44.86  ? 594 HOH B O   1 
HETATM 9347 O  O   . HOH H 4 .   ? -32.513 17.198  8.92    1    70.46  ? 595 HOH B O   1 
HETATM 9348 O  O   . HOH H 4 .   ? -13.903 17.819  7.191   1    52.88  ? 596 HOH B O   1 
HETATM 9349 O  O   . HOH H 4 .   ? -19.827 -9.357  10.529  1    50.23  ? 597 HOH B O   1 
HETATM 9350 O  O   . HOH H 4 .   ? -17.754 -13.594 -14.932 1    52.7   ? 598 HOH B O   1 
HETATM 9351 O  O   . HOH H 4 .   ? -22.758 -0.594  0.846   1    59.95  ? 599 HOH B O   1 
HETATM 9352 O  O   . HOH H 4 .   ? -7.459  18.248  14.835  1    62.41  ? 600 HOH B O   1 
HETATM 9353 O  O   . HOH H 4 .   ? -7.958  10.028  -7.116  1    56.65  ? 601 HOH B O   1 
HETATM 9354 O  O   . HOH H 4 .   ? -33.075 -5.177  -27.477 1    60.56  ? 602 HOH B O   1 
HETATM 9355 O  O   . HOH H 4 .   ? -25.812 20.696  2.153   1    45.95  ? 603 HOH B O   1 
HETATM 9356 O  O   . HOH H 4 .   ? -34.919 -3.484  -1.845  1    60.88  ? 604 HOH B O   1 
HETATM 9357 O  O   . HOH H 4 .   ? -35.933 4.444   8.164   1    63.47  ? 605 HOH B O   1 
HETATM 9358 O  O   . HOH H 4 .   ? -24.053 -20.021 -13.396 1    63.92  ? 606 HOH B O   1 
HETATM 9359 O  O   . HOH H 4 .   ? -31.493 3.658   -26.827 1    70.63  ? 607 HOH B O   1 
HETATM 9360 O  O   . HOH H 4 .   ? -18.742 16.464  3.073   1    63.14  ? 608 HOH B O   1 
HETATM 9361 O  O   . HOH H 4 .   ? -29.358 -12.776 -20.706 1    65.74  ? 609 HOH B O   1 
HETATM 9362 O  O   . HOH H 4 .   ? -9.3    7.526   -11.228 1    49.61  ? 610 HOH B O   1 
HETATM 9363 O  O   . HOH H 4 .   ? -23.619 2.269   -25.596 1    71.18  ? 611 HOH B O   1 
HETATM 9364 O  O   . HOH H 4 .   ? -26.228 -1.639  11.811  1    52.82  ? 612 HOH B O   1 
HETATM 9365 O  O   . HOH H 4 .   ? -35.45  -8.515  -1.326  1    38.67  ? 613 HOH B O   1 
HETATM 9366 O  O   . HOH H 4 .   ? -6.201  -6.546  -1.854  1    36.67  ? 614 HOH B O   1 
HETATM 9367 O  O   . HOH H 4 .   ? -21.65  3.418   -26.535 1    69.77  ? 615 HOH B O   1 
HETATM 9368 O  O   . HOH H 4 .   ? -17.326 19.347  16.616  1    59.84  ? 616 HOH B O   1 
HETATM 9369 O  O   . HOH H 4 .   ? -32.685 -11.645 -23.335 1    55.19  ? 617 HOH B O   1 
HETATM 9370 O  O   . HOH H 4 .   ? -9.498  -7.254  -8.381  1    57.55  ? 618 HOH B O   1 
HETATM 9371 O  O   . HOH H 4 .   ? -43.369 -4.53   -14.529 1    69.99  ? 619 HOH B O   1 
HETATM 9372 O  O   . HOH H 4 .   ? -27.218 2.383   -0.826  1    50.44  ? 620 HOH B O   1 
HETATM 9373 O  O   . HOH H 4 .   ? -11.328 18.161  14.52   1    46.54  ? 621 HOH B O   1 
HETATM 9374 O  O   . HOH H 4 .   ? -26.156 16.656  -8.25   1    51.92  ? 622 HOH B O   1 
HETATM 9375 O  O   . HOH H 4 .   ? -28.227 -19.048 6.081   1    64.45  ? 623 HOH B O   1 
HETATM 9376 O  O   . HOH H 4 .   ? -18.853 -7.322  19.557  1    55.72  ? 624 HOH B O   1 
HETATM 9377 O  O   . HOH H 4 .   ? -27.606 20.972  7.575   1    61.49  ? 625 HOH B O   1 
HETATM 9378 O  O   . HOH H 4 .   ? -26.37  25.794  8.083   1    56.49  ? 626 HOH B O   1 
HETATM 9379 O  O   . HOH H 4 .   ? -13.244 19.133  13.254  1    54.67  ? 627 HOH B O   1 
HETATM 9380 O  O   . HOH H 4 .   ? -10.403 16.385  1.048   1    62.74  ? 628 HOH B O   1 
HETATM 9381 O  O   . HOH H 4 .   ? -22.17  -0.653  -26.417 1    63.04  ? 629 HOH B O   1 
HETATM 9382 O  O   . HOH H 4 .   ? -27.322 -0.697  -0.627  1    51.59  ? 630 HOH B O   1 
HETATM 9383 O  O   . HOH H 4 .   ? -28.899 11.348  -10.514 1    48.05  ? 631 HOH B O   1 
HETATM 9384 O  O   . HOH H 4 .   ? -39.095 -10.333 -5.189  1    70.37  ? 632 HOH B O   1 
HETATM 9385 O  O   . HOH H 4 .   ? -42.786 -3.245  -7.993  1    61.34  ? 633 HOH B O   1 
HETATM 9386 O  O   . HOH H 4 .   ? -18.526 -15.553 -16.53  1    46.74  ? 634 HOH B O   1 
HETATM 9387 O  O   . HOH H 4 .   ? -7.73   16.817  18.717  1    57.29  ? 635 HOH B O   1 
HETATM 9388 O  O   . HOH H 4 .   ? -35.718 4.433   -28.498 1    62.51  ? 636 HOH B O   1 
HETATM 9389 O  O   . HOH H 4 .   ? -37.61  -14.906 -17.94  1    54.89  ? 637 HOH B O   1 
HETATM 9390 O  O   . HOH H 4 .   ? -26.571 -20.475 -15.632 1    55.17  ? 638 HOH B O   1 
HETATM 9391 O  O   . HOH H 4 .   ? -31.762 -21.665 -6.459  1    71.66  ? 639 HOH B O   1 
HETATM 9392 O  O   . HOH H 4 .   ? -34.863 -9.731  1.175   1    45.99  ? 640 HOH B O   1 
HETATM 9393 O  O   . HOH H 4 .   ? -24.218 10.114  -11.205 1    49.76  ? 641 HOH B O   1 
HETATM 9394 O  O   . HOH H 4 .   ? -37.702 -9.844  -1.853  1    50.91  ? 642 HOH B O   1 
HETATM 9395 O  O   . HOH H 4 .   ? -43.085 -0.635  -10.379 1    68.34  ? 643 HOH B O   1 
HETATM 9396 O  O   . HOH H 4 .   ? -27.625 -1.347  2.204   1    58.49  ? 644 HOH B O   1 
HETATM 9397 O  O   . HOH H 4 .   ? -8.947  -7.032  -11.328 1    69.04  ? 645 HOH B O   1 
HETATM 9398 O  O   . HOH H 4 .   ? -15.957 -11.539 -10.758 1    44.76  ? 646 HOH B O   1 
HETATM 9399 O  O   . HOH H 4 .   ? -36.372 -5.898  -1.818  1    44.46  ? 647 HOH B O   1 
HETATM 9400 O  O   . HOH H 4 .   ? -38.576 2.543   2.188   1    63.75  ? 648 HOH B O   1 
HETATM 9401 O  O   . HOH H 4 .   ? -25.078 -0.252  -1.181  1    53.08  ? 649 HOH B O   1 
HETATM 9402 O  O   . HOH H 4 .   ? -37.224 5.858   -31.032 1    66.56  ? 650 HOH B O   1 
HETATM 9403 O  O   . HOH I 4 .   ? -24.933 0.905   23.875  1    62.69  ? 401 HOH C O   1 
HETATM 9404 O  O   . HOH I 4 .   ? -47.295 40.362  30.042  1    62.42  ? 402 HOH C O   1 
HETATM 9405 O  O   . HOH I 4 .   ? -23.663 25.353  26.792  1    68.46  ? 403 HOH C O   1 
HETATM 9406 O  O   . HOH I 4 .   ? -28.615 16.236  21.134  1    51.51  ? 404 HOH C O   1 
HETATM 9407 O  O   . HOH I 4 .   ? -41.857 4.741   37.602  1    53.53  ? 405 HOH C O   1 
HETATM 9408 O  O   . HOH I 4 .   ? -35.678 29.283  17.778  1    63.63  ? 406 HOH C O   1 
HETATM 9409 O  O   . HOH I 4 .   ? -28.697 13.959  19.168  1    60.07  ? 407 HOH C O   1 
HETATM 9410 O  O   . HOH I 4 .   ? -27.364 10.353  17.768  1    41.84  ? 408 HOH C O   1 
HETATM 9411 O  O   . HOH I 4 .   ? -40.129 2.185   41.341  1    49.86  ? 409 HOH C O   1 
HETATM 9412 O  O   . HOH I 4 .   ? -43.225 5.198   42.006  1    52.83  ? 410 HOH C O   1 
HETATM 9413 O  O   . HOH I 4 .   ? -45.693 -2.354  35.395  1    39.05  ? 411 HOH C O   1 
HETATM 9414 O  O   . HOH I 4 .   ? -30.32  17.832  20.275  1    58.77  ? 412 HOH C O   1 
HETATM 9415 O  O   . HOH I 4 .   ? -39.344 0.439   44.181  1    50.02  ? 413 HOH C O   1 
HETATM 9416 O  O   . HOH I 4 .   ? -43.966 24.53   17.018  1    53.33  ? 414 HOH C O   1 
HETATM 9417 O  O   . HOH I 4 .   ? -40.918 38.023  29.043  1    68.39  ? 415 HOH C O   1 
HETATM 9418 O  O   . HOH I 4 .   ? -49.431 13.147  34.463  1    45.45  ? 416 HOH C O   1 
HETATM 9419 O  O   . HOH I 4 .   ? -46.157 28.785  34.773  1    59.56  ? 417 HOH C O   1 
HETATM 9420 O  O   . HOH I 4 .   ? -46.937 21.209  15.411  1    55.44  ? 418 HOH C O   1 
HETATM 9421 O  O   . HOH I 4 .   ? -47.522 11.423  15.959  1    62.74  ? 419 HOH C O   1 
HETATM 9422 O  O   . HOH I 4 .   ? -32.939 20.923  34.888  1    69.62  ? 420 HOH C O   1 
HETATM 9423 O  O   . HOH I 4 .   ? -41.109 2.554   19.331  1    72.73  ? 421 HOH C O   1 
HETATM 9424 O  O   . HOH I 4 .   ? -54.419 2.134   38.591  1    42.13  ? 422 HOH C O   1 
HETATM 9425 O  O   . HOH I 4 .   ? -42.355 1.232   42.553  1    42.96  ? 423 HOH C O   1 
HETATM 9426 O  O   . HOH I 4 .   ? -57.607 6.911   41.896  1    69.16  ? 424 HOH C O   1 
HETATM 9427 O  O   . HOH I 4 .   ? -49.172 3.503   46.795  1    57.63  ? 425 HOH C O   1 
HETATM 9428 O  O   . HOH I 4 .   ? -42.411 33.636  23.975  1    61.92  ? 426 HOH C O   1 
HETATM 9429 O  O   . HOH I 4 .   ? -58.123 7.551   35.613  1    43.44  ? 427 HOH C O   1 
HETATM 9430 O  O   . HOH I 4 .   ? -49.475 0.704   19.705  1    69.9   ? 428 HOH C O   1 
HETATM 9431 O  O   . HOH I 4 .   ? -37.557 12.015  19.78   1    49.21  ? 429 HOH C O   1 
HETATM 9432 O  O   . HOH I 4 .   ? -49.192 32.757  27.113  1    67.76  ? 430 HOH C O   1 
HETATM 9433 O  O   . HOH I 4 .   ? -51.427 24.265  35.598  1    51.08  ? 431 HOH C O   1 
HETATM 9434 O  O   . HOH I 4 .   ? -55.187 9.16    26.281  1    48.13  ? 432 HOH C O   1 
HETATM 9435 O  O   . HOH I 4 .   ? -24.338 0.12    48.356  1    48.85  ? 433 HOH C O   1 
HETATM 9436 O  O   . HOH I 4 .   ? -43.867 -0.67   34.932  1    40.22  ? 434 HOH C O   1 
HETATM 9437 O  O   . HOH I 4 .   ? -55.043 17.924  52.587  1    57.64  ? 435 HOH C O   1 
HETATM 9438 O  O   . HOH I 4 .   ? -58.951 10.288  29.017  1    55.08  ? 436 HOH C O   1 
HETATM 9439 O  O   . HOH I 4 .   ? -37.508 24.444  35.379  1    63.97  ? 437 HOH C O   1 
HETATM 9440 O  O   . HOH I 4 .   ? -48.882 -3.532  34.743  1    65.06  ? 438 HOH C O   1 
HETATM 9441 O  O   . HOH I 4 .   ? -65.375 24.352  15.575  1    68.45  ? 439 HOH C O   1 
HETATM 9442 O  O   . HOH I 4 .   ? -44.467 15.768  15.838  1    53.47  ? 440 HOH C O   1 
HETATM 9443 O  O   . HOH I 4 .   ? -19.007 4.229   26.095  1    57.8   ? 441 HOH C O   1 
HETATM 9444 O  O   . HOH I 4 .   ? -42.532 9.524   34.776  1    36.48  ? 442 HOH C O   1 
HETATM 9445 O  O   . HOH I 4 .   ? -57.348 8.267   27.554  1    45.32  ? 443 HOH C O   1 
HETATM 9446 O  O   . HOH I 4 .   ? -54.881 19.236  39.489  1    43.22  ? 444 HOH C O   1 
HETATM 9447 O  O   . HOH I 4 .   ? -52.227 23.105  37.988  1    48.7   ? 445 HOH C O   1 
HETATM 9448 O  O   . HOH I 4 .   ? -44.014 7.2     43.74   1    58.36  ? 446 HOH C O   1 
HETATM 9449 O  O   . HOH I 4 .   ? -47.81  -3.994  31.1    1    76.54  ? 447 HOH C O   1 
HETATM 9450 O  O   . HOH I 4 .   ? -29.944 2.689   43.451  1    68.71  ? 448 HOH C O   1 
HETATM 9451 O  O   . HOH I 4 .   ? -14.081 17.864  19.434  1    58.99  ? 449 HOH C O   1 
HETATM 9452 O  O   . HOH I 4 .   ? -54.703 6.692   43.626  1    45.68  ? 450 HOH C O   1 
HETATM 9453 O  O   . HOH I 4 .   ? -36.943 16.186  34.92   1    50.92  ? 451 HOH C O   1 
HETATM 9454 O  O   . HOH I 4 .   ? -28.123 -1.73   28.195  1    53.28  ? 452 HOH C O   1 
HETATM 9455 O  O   . HOH I 4 .   ? -74.484 11.375  33.952  1    59.53  ? 453 HOH C O   1 
HETATM 9456 O  O   . HOH I 4 .   ? -35.484 0.712   44.02   1    51.89  ? 454 HOH C O   1 
HETATM 9457 O  O   . HOH I 4 .   ? -50.219 6.459   19.172  1    50.23  ? 455 HOH C O   1 
HETATM 9458 O  O   . HOH I 4 .   ? -27.417 1.284   24.03   1    63.24  ? 456 HOH C O   1 
HETATM 9459 O  O   . HOH I 4 .   ? -72.481 8.255   48.749  1    60.8   ? 457 HOH C O   1 
HETATM 9460 O  O   . HOH I 4 .   ? -31.279 1.002   44.613  1    69.2   ? 458 HOH C O   1 
HETATM 9461 O  O   . HOH I 4 .   ? -43.968 13.916  41.319  1    60.26  ? 459 HOH C O   1 
HETATM 9462 O  O   . HOH I 4 .   ? -54.283 2.568   41.121  1    50.09  ? 460 HOH C O   1 
HETATM 9463 O  O   . HOH I 4 .   ? -55.134 -4.533  41.673  1    59.99  ? 461 HOH C O   1 
HETATM 9464 O  O   . HOH I 4 .   ? -13.649 5.635   21.216  1    51.79  ? 462 HOH C O   1 
HETATM 9465 O  O   . HOH I 4 .   ? -34.196 2.111   21.812  1    65.35  ? 463 HOH C O   1 
HETATM 9466 O  O   . HOH I 4 .   ? -25.83  17.987  18.697  1    55.73  ? 464 HOH C O   1 
HETATM 9467 O  O   . HOH I 4 .   ? -41.953 32.623  21.709  1    58.92  ? 465 HOH C O   1 
HETATM 9468 O  O   . HOH I 4 .   ? -54.266 23.457  53.332  1    64.7   ? 466 HOH C O   1 
HETATM 9469 O  O   . HOH I 4 .   ? -53.449 4.003   43.81   1    53.91  ? 467 HOH C O   1 
HETATM 9470 O  O   . HOH I 4 .   ? -35.033 13.999  33.096  1    82.76  ? 468 HOH C O   1 
HETATM 9471 O  O   . HOH I 4 .   ? -65.237 19.641  34.54   1    55.55  ? 469 HOH C O   1 
HETATM 9472 O  O   . HOH I 4 .   ? -48.35  39.86   24.293  1    59     ? 470 HOH C O   1 
HETATM 9473 O  O   . HOH I 4 .   ? -49.101 9.015   18.408  1    50.75  ? 471 HOH C O   1 
HETATM 9474 O  O   . HOH I 4 .   ? -61.538 3.314   41.256  1    45.08  ? 472 HOH C O   1 
HETATM 9475 O  O   . HOH I 4 .   ? -26.417 2.817   21.979  1    47.4   ? 473 HOH C O   1 
HETATM 9476 O  O   . HOH I 4 .   ? -13.359 13.627  29.365  1    71.73  ? 474 HOH C O   1 
HETATM 9477 O  O   . HOH I 4 .   ? -52.184 16.939  51.907  1    61.3   ? 475 HOH C O   1 
HETATM 9478 O  O   . HOH I 4 .   ? -54.181 28.491  34.397  1    69.69  ? 476 HOH C O   1 
HETATM 9479 O  O   . HOH I 4 .   ? -46.157 17.591  14.879  1    57.59  ? 477 HOH C O   1 
HETATM 9480 O  O   . HOH I 4 .   ? -65.24  22.588  19.378  1    67.11  ? 478 HOH C O   1 
HETATM 9481 O  O   . HOH I 4 .   ? -12.458 17.737  23.285  1    66.55  ? 479 HOH C O   1 
HETATM 9482 O  O   . HOH I 4 .   ? -43.729 31.62   18.289  1    66.6   ? 480 HOH C O   1 
HETATM 9483 O  O   . HOH I 4 .   ? -62.581 10.031  25.004  1    60.59  ? 481 HOH C O   1 
HETATM 9484 O  O   . HOH I 4 .   ? -36.683 16.152  37.684  1    61.91  ? 482 HOH C O   1 
HETATM 9485 O  O   . HOH I 4 .   ? -21.214 1.768   45.945  1    66.56  ? 483 HOH C O   1 
HETATM 9486 O  O   . HOH I 4 .   ? -22.654 4.391   21.044  1    62.16  ? 484 HOH C O   1 
HETATM 9487 O  O   . HOH I 4 .   ? -38.837 9.315   16.457  1    58.06  ? 485 HOH C O   1 
HETATM 9488 O  O   . HOH I 4 .   ? -65.152 7.132   37.491  1    73.37  ? 486 HOH C O   1 
HETATM 9489 O  O   . HOH I 4 .   ? -55.3   31.049  12.882  1    64.29  ? 487 HOH C O   1 
HETATM 9490 O  O   . HOH I 4 .   ? -19.858 -4.906  43.981  1    75.95  ? 488 HOH C O   1 
HETATM 9491 O  O   . HOH I 4 .   ? -49.793 35.433  25.548  1    68.48  ? 489 HOH C O   1 
HETATM 9492 O  O   . HOH I 4 .   ? -15.294 15.279  30.975  1    51.33  ? 490 HOH C O   1 
HETATM 9493 O  O   . HOH I 4 .   ? -35.497 20.264  33.117  1    66.98  ? 491 HOH C O   1 
HETATM 9494 O  O   . HOH I 4 .   ? -18.859 7.003   23.001  1    41.77  ? 492 HOH C O   1 
HETATM 9495 O  O   . HOH I 4 .   ? -67.226 17.703  34.165  1    54     ? 493 HOH C O   1 
HETATM 9496 O  O   . HOH I 4 .   ? -41.123 4.966   40.58   1    42.99  ? 494 HOH C O   1 
HETATM 9497 O  O   . HOH I 4 .   ? -57.123 27.486  41.911  1    65.16  ? 495 HOH C O   1 
HETATM 9498 O  O   . HOH I 4 .   ? -58.807 5.723   26.673  1    49.4   ? 496 HOH C O   1 
HETATM 9499 O  O   . HOH I 4 .   ? -59.313 15.42   51.147  1    74.39  ? 497 HOH C O   1 
HETATM 9500 O  O   . HOH J 4 .   ? -40.882 -29.758 33.39   1    59.14  ? 501 HOH D O   1 
HETATM 9501 O  O   . HOH J 4 .   ? -47.699 -12.832 18.518  1    51.28  ? 502 HOH D O   1 
HETATM 9502 O  O   . HOH J 4 .   ? -27.246 -4.591  40.909  1    50.99  ? 503 HOH D O   1 
HETATM 9503 O  O   . HOH J 4 .   ? -46.698 -30.375 31.393  1    58.74  ? 504 HOH D O   1 
HETATM 9504 O  O   . HOH J 4 .   ? -53.22  -14.41  15.115  1    58.83  ? 505 HOH D O   1 
HETATM 9505 O  O   . HOH J 4 .   ? -31.708 -5.248  51.708  1    69.31  ? 506 HOH D O   1 
HETATM 9506 O  O   . HOH J 4 .   ? -48.995 -31.7   34.911  1    66.45  ? 507 HOH D O   1 
HETATM 9507 O  O   . HOH J 4 .   ? -47.478 -41.012 29.455  1    64.21  ? 508 HOH D O   1 
HETATM 9508 O  O   . HOH J 4 .   ? -50.23  -5.057  29.044  1    47.11  ? 509 HOH D O   1 
HETATM 9509 O  O   . HOH J 4 .   ? -19.809 -11.993 47.873  1    70.85  ? 510 HOH D O   1 
HETATM 9510 O  O   . HOH J 4 .   ? -42.658 -22.921 30.349  1    65.85  ? 511 HOH D O   1 
HETATM 9511 O  O   . HOH J 4 .   ? -38.544 -26.242 44.166  1    54.73  ? 512 HOH D O   1 
HETATM 9512 O  O   . HOH J 4 .   ? -38.686 -26.657 32.907  1    49.08  ? 513 HOH D O   1 
HETATM 9513 O  O   . HOH J 4 .   ? -59.928 -8.741  33.046  1    55.52  ? 514 HOH D O   1 
HETATM 9514 O  O   . HOH J 4 .   ? -22.391 -7.632  37.478  1    49.69  ? 515 HOH D O   1 
HETATM 9515 O  O   . HOH J 4 .   ? -49.159 -15.953 17.465  1    53.65  ? 516 HOH D O   1 
HETATM 9516 O  O   . HOH J 4 .   ? -39.505 -29.246 43.628  1    65.45  ? 517 HOH D O   1 
HETATM 9517 O  O   . HOH J 4 .   ? -28.938 -23.375 44.717  1    40.18  ? 518 HOH D O   1 
HETATM 9518 O  O   . HOH J 4 .   ? -48.204 -7.628  45.584  1    42.69  ? 519 HOH D O   1 
HETATM 9519 O  O   . HOH J 4 .   ? -28.777 -23.228 42.127  1    45.03  ? 520 HOH D O   1 
HETATM 9520 O  O   . HOH J 4 .   ? -33.5   -31.846 38.661  1    53.05  ? 521 HOH D O   1 
HETATM 9521 O  O   . HOH J 4 .   ? -31.615 -22.756 20.473  1    73.99  ? 522 HOH D O   1 
HETATM 9522 O  O   . HOH J 4 .   ? -53.456 -12.869 20.979  1    61.62  ? 523 HOH D O   1 
HETATM 9523 O  O   . HOH J 4 .   ? -42.941 -12.127 26.043  1    68.4   ? 524 HOH D O   1 
HETATM 9524 O  O   . HOH J 4 .   ? -46.43  -4.539  46.04   1    63.25  ? 525 HOH D O   1 
HETATM 9525 O  O   . HOH J 4 .   ? -40.852 -1.129  42.439  1    48.67  ? 526 HOH D O   1 
HETATM 9526 O  O   . HOH J 4 .   ? -43.595 -28.356 45.009  1    58.94  ? 527 HOH D O   1 
HETATM 9527 O  O   . HOH J 4 .   ? -38.948 -3.327  28.009  1    50.29  ? 528 HOH D O   1 
HETATM 9528 O  O   . HOH J 4 .   ? -25.154 -25.231 31.688  1    42.55  ? 529 HOH D O   1 
HETATM 9529 O  O   . HOH J 4 .   ? -40.649 -33.795 28.637  1    58.57  ? 530 HOH D O   1 
HETATM 9530 O  O   . HOH J 4 .   ? -52.601 -6.316  29.145  1    45.2   ? 531 HOH D O   1 
HETATM 9531 O  O   . HOH J 4 .   ? -43.227 -20.001 26.628  1    54.36  ? 532 HOH D O   1 
HETATM 9532 O  O   . HOH J 4 .   ? -46.112 -15.488 30.907  1    48.29  ? 533 HOH D O   1 
HETATM 9533 O  O   . HOH J 4 .   ? -40.217 -29.836 30.702  1    49.07  ? 534 HOH D O   1 
HETATM 9534 O  O   . HOH J 4 .   ? -46.224 -26.015 40.78   1    55.1   ? 535 HOH D O   1 
HETATM 9535 O  O   . HOH J 4 .   ? -44.179 -34.025 44.613  1    64.4   ? 536 HOH D O   1 
HETATM 9536 O  O   . HOH J 4 .   ? -67.585 -20.193 20.569  1    59.19  ? 537 HOH D O   1 
HETATM 9537 O  O   . HOH J 4 .   ? -42.079 -27.381 48.557  1    52.61  ? 538 HOH D O   1 
HETATM 9538 O  O   . HOH J 4 .   ? -62.202 3.174   38.981  1    63     ? 539 HOH D O   1 
HETATM 9539 O  O   . HOH J 4 .   ? -56.302 1.252   19.978  1    58.9   ? 540 HOH D O   1 
HETATM 9540 O  O   . HOH J 4 .   ? -43.448 -15.511 31.04   1    46.94  ? 541 HOH D O   1 
HETATM 9541 O  O   . HOH J 4 .   ? -31.165 -11.842 54.966  1    56.89  ? 542 HOH D O   1 
HETATM 9542 O  O   . HOH J 4 .   ? -41.37  -7.796  51.61   1    66.32  ? 543 HOH D O   1 
HETATM 9543 O  O   . HOH J 4 .   ? -58.919 0.388   20.485  1    58.07  ? 544 HOH D O   1 
HETATM 9544 O  O   . HOH J 4 .   ? -42.515 -14.462 24.813  1    63.91  ? 545 HOH D O   1 
HETATM 9545 O  O   . HOH J 4 .   ? -20.379 -22.462 40.113  1    56.91  ? 546 HOH D O   1 
HETATM 9546 O  O   . HOH J 4 .   ? -43.099 -34.131 37.155  1    64.96  ? 547 HOH D O   1 
HETATM 9547 O  O   . HOH J 4 .   ? -38.768 -26.824 24.884  1    65.51  ? 548 HOH D O   1 
HETATM 9548 O  O   . HOH J 4 .   ? -51.081 -24.296 19.379  1    62.6   ? 549 HOH D O   1 
HETATM 9549 O  O   . HOH J 4 .   ? -19.804 -4.448  36.204  1    66.84  ? 550 HOH D O   1 
HETATM 9550 O  O   . HOH J 4 .   ? -51.006 -16.457 36.829  1    57.65  ? 551 HOH D O   1 
HETATM 9551 O  O   . HOH J 4 .   ? -48.558 -27.6   40.775  1    60.34  ? 552 HOH D O   1 
HETATM 9552 O  O   . HOH J 4 .   ? -41.001 -18.245 28.585  1    62.28  ? 553 HOH D O   1 
HETATM 9553 O  O   . HOH J 4 .   ? -45.962 -28.19  38.093  1    56.77  ? 554 HOH D O   1 
HETATM 9554 O  O   . HOH J 4 .   ? -27.365 -11.248 25.423  1    64.39  ? 555 HOH D O   1 
HETATM 9555 O  O   . HOH J 4 .   ? -57.685 -15.241 39.927  1    59.97  ? 556 HOH D O   1 
HETATM 9556 O  O   . HOH J 4 .   ? -27.864 -30.883 30.365  1    64.13  ? 557 HOH D O   1 
HETATM 9557 O  O   . HOH J 4 .   ? -50.86  -10.302 46.555  1    58.58  ? 558 HOH D O   1 
HETATM 9558 O  O   . HOH J 4 .   ? -26.322 -4.026  27.873  1    61.7   ? 559 HOH D O   1 
HETATM 9559 O  O   . HOH J 4 .   ? -50.952 -9.996  38.859  1    44.44  ? 560 HOH D O   1 
HETATM 9560 O  O   . HOH J 4 .   ? -48.03  -4.152  43.377  1    50.16  ? 561 HOH D O   1 
HETATM 9561 O  O   . HOH J 4 .   ? -38.464 -32.34  30.208  1    60.45  ? 562 HOH D O   1 
HETATM 9562 O  O   . HOH J 4 .   ? -45.14  -20.426 30.078  1    54.73  ? 563 HOH D O   1 
HETATM 9563 O  O   . HOH J 4 .   ? -28.474 -7.353  54.75   1    45.85  ? 564 HOH D O   1 
HETATM 9564 O  O   . HOH J 4 .   ? -50.629 -23.996 15.319  1    65.69  ? 565 HOH D O   1 
HETATM 9565 O  O   . HOH J 4 .   ? -35.153 -32.918 32.629  1    59.99  ? 566 HOH D O   1 
HETATM 9566 O  O   . HOH J 4 .   ? -25.977 -23.773 45.153  1    55.17  ? 567 HOH D O   1 
HETATM 9567 O  O   . HOH J 4 .   ? -35.611 -20.736 18.927  1    62.63  ? 568 HOH D O   1 
HETATM 9568 O  O   . HOH J 4 .   ? -55.225 -34.214 25.578  1    67.73  ? 569 HOH D O   1 
HETATM 9569 O  O   . HOH J 4 .   ? -67.676 -9.885  23.346  1    71.35  ? 570 HOH D O   1 
HETATM 9570 O  O   . HOH J 4 .   ? -46.814 -19.776 19.136  1    44.23  ? 571 HOH D O   1 
HETATM 9571 O  O   . HOH J 4 .   ? -44.852 -18.361 27.188  1    56.39  ? 572 HOH D O   1 
HETATM 9572 O  O   . HOH J 4 .   ? -51.228 -13.291 13.089  1    59.26  ? 573 HOH D O   1 
HETATM 9573 O  O   . HOH J 4 .   ? -32.105 -31.044 26.938  1    79.33  ? 574 HOH D O   1 
HETATM 9574 O  O   . HOH J 4 .   ? -49.557 -6.243  33.745  1    71.92  ? 575 HOH D O   1 
HETATM 9575 O  O   . HOH J 4 .   ? -31.225 -31.119 29.002  1    62.98  ? 576 HOH D O   1 
HETATM 9576 O  O   . HOH J 4 .   ? -18.955 -11.559 45.054  1    61.96  ? 577 HOH D O   1 
HETATM 9577 O  O   . HOH J 4 .   ? -25.251 -3.06   41.511  1    54.29  ? 578 HOH D O   1 
HETATM 9578 O  O   . HOH J 4 .   ? -49.626 -43.212 29.246  1    60.89  ? 579 HOH D O   1 
HETATM 9579 O  O   . HOH J 4 .   ? -39.254 -32.19  35.417  1    48.95  ? 580 HOH D O   1 
HETATM 9580 O  O   . HOH J 4 .   ? -42.361 -17.058 25.973  1    65.65  ? 581 HOH D O   1 
HETATM 9581 O  O   . HOH J 4 .   ? -50.965 0.184   47.495  1    70.99  ? 582 HOH D O   1 
HETATM 9582 O  O   . HOH J 4 .   ? -48.157 -18.633 17.476  1    54.05  ? 583 HOH D O   1 
HETATM 9583 O  O   . HOH J 4 .   ? -54.834 -35.739 18.766  1    72.84  ? 584 HOH D O   1 
HETATM 9584 O  O   . HOH J 4 .   ? -44.697 -17.859 29.493  1    37.63  ? 585 HOH D O   1 
HETATM 9585 O  O   . HOH J 4 .   ? -51.58  -13.596 10.408  1    60.5   ? 586 HOH D O   1 
# 
