data_9ESJ
# 
_entry.id   9ESJ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9ESJ         pdb_00009esj 10.2210/pdb9esj/pdb 
WWPDB D_1292137176 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-09 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9ESJ 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-26 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 jane.endicott@newcastle.ac.uk Jane    Endicott A.   'principal investigator/group leader' 0000-0003-4868-0116 
4 martin.noble@newcastle.ac.uk  Martin  Noble    E.M. 'principal investigator/group leader' 0000-0002-3595-9807 
5 mike.waring@newcastle.ac.uk   Michael Waring   J.   'principal investigator/group leader' 0000-0002-9110-8783 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hope, I.'       1 0000-0002-8002-5026 
'Martin, M.P.'   2 0000-0003-4810-3351 
'Waring, M.J.'   3 0000-0002-9110-8783 
'Noble, M.E.M.'  4 0000-0002-3595-9807 
'Endicott, J.A.' 5 0000-0003-4868-0116 
'Tatum, N.J.'    6 0000-0003-3878-9265 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hope, I.'       1 0000-0002-8002-5026 
primary 'Martin, M.P.'   2 0000-0003-4810-3351 
primary 'Waring, M.J.'   3 0000-0002-9110-8783 
primary 'Noble, M.E.M.'  4 0000-0002-3595-9807 
primary 'Endicott, J.A.' 5 0000-0003-4868-0116 
primary 'Tatum, N.J.'    6 0000-0003-3878-9265 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Cyclin-dependent kinase 2'                    34354.770 2   2.7.11.22 ? ? ? 
2 polymer     man Cyclin-A2                                      30817.473 2   ?         ? ? ? 
3 non-polymer syn '2-(4-bromanyl-2-methoxy-phenyl)ethanoic acid' 245.070   10  ?         ? ? ? 
4 water       nat water                                          18.015    366 ?         ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'Cell division protein kinase 2,p33 protein kinase' 
2 Cyclin-A                                            
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no yes 
;GPGSMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKL
YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV
RTY(TPO)HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS
MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
;
;GPGSMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKL
YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV
RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY
KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
;
A,C ? 
2 'polypeptide(L)' no no  
;GVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLR
GKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVE
SLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIR
EKYKNSKYHGVSLLNPPETLNVHHHHHH
;
;GVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLR
GKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVE
SLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIR
EKYKNSKYHGVSLLNPPETLNVHHHHHH
;
B,D ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '2-(4-bromanyl-2-methoxy-phenyl)ethanoic acid' HHT 
4 water                                          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   SER n 
1 5   MET n 
1 6   GLU n 
1 7   ASN n 
1 8   PHE n 
1 9   GLN n 
1 10  LYS n 
1 11  VAL n 
1 12  GLU n 
1 13  LYS n 
1 14  ILE n 
1 15  GLY n 
1 16  GLU n 
1 17  GLY n 
1 18  THR n 
1 19  TYR n 
1 20  GLY n 
1 21  VAL n 
1 22  VAL n 
1 23  TYR n 
1 24  LYS n 
1 25  ALA n 
1 26  ARG n 
1 27  ASN n 
1 28  LYS n 
1 29  LEU n 
1 30  THR n 
1 31  GLY n 
1 32  GLU n 
1 33  VAL n 
1 34  VAL n 
1 35  ALA n 
1 36  LEU n 
1 37  LYS n 
1 38  LYS n 
1 39  ILE n 
1 40  ARG n 
1 41  LEU n 
1 42  ASP n 
1 43  THR n 
1 44  GLU n 
1 45  THR n 
1 46  GLU n 
1 47  GLY n 
1 48  VAL n 
1 49  PRO n 
1 50  SER n 
1 51  THR n 
1 52  ALA n 
1 53  ILE n 
1 54  ARG n 
1 55  GLU n 
1 56  ILE n 
1 57  SER n 
1 58  LEU n 
1 59  LEU n 
1 60  LYS n 
1 61  GLU n 
1 62  LEU n 
1 63  ASN n 
1 64  HIS n 
1 65  PRO n 
1 66  ASN n 
1 67  ILE n 
1 68  VAL n 
1 69  LYS n 
1 70  LEU n 
1 71  LEU n 
1 72  ASP n 
1 73  VAL n 
1 74  ILE n 
1 75  HIS n 
1 76  THR n 
1 77  GLU n 
1 78  ASN n 
1 79  LYS n 
1 80  LEU n 
1 81  TYR n 
1 82  LEU n 
1 83  VAL n 
1 84  PHE n 
1 85  GLU n 
1 86  PHE n 
1 87  LEU n 
1 88  HIS n 
1 89  GLN n 
1 90  ASP n 
1 91  LEU n 
1 92  LYS n 
1 93  LYS n 
1 94  PHE n 
1 95  MET n 
1 96  ASP n 
1 97  ALA n 
1 98  SER n 
1 99  ALA n 
1 100 LEU n 
1 101 THR n 
1 102 GLY n 
1 103 ILE n 
1 104 PRO n 
1 105 LEU n 
1 106 PRO n 
1 107 LEU n 
1 108 ILE n 
1 109 LYS n 
1 110 SER n 
1 111 TYR n 
1 112 LEU n 
1 113 PHE n 
1 114 GLN n 
1 115 LEU n 
1 116 LEU n 
1 117 GLN n 
1 118 GLY n 
1 119 LEU n 
1 120 ALA n 
1 121 PHE n 
1 122 CYS n 
1 123 HIS n 
1 124 SER n 
1 125 HIS n 
1 126 ARG n 
1 127 VAL n 
1 128 LEU n 
1 129 HIS n 
1 130 ARG n 
1 131 ASP n 
1 132 LEU n 
1 133 LYS n 
1 134 PRO n 
1 135 GLN n 
1 136 ASN n 
1 137 LEU n 
1 138 LEU n 
1 139 ILE n 
1 140 ASN n 
1 141 THR n 
1 142 GLU n 
1 143 GLY n 
1 144 ALA n 
1 145 ILE n 
1 146 LYS n 
1 147 LEU n 
1 148 ALA n 
1 149 ASP n 
1 150 PHE n 
1 151 GLY n 
1 152 LEU n 
1 153 ALA n 
1 154 ARG n 
1 155 ALA n 
1 156 PHE n 
1 157 GLY n 
1 158 VAL n 
1 159 PRO n 
1 160 VAL n 
1 161 ARG n 
1 162 THR n 
1 163 TYR n 
1 164 TPO n 
1 165 HIS n 
1 166 GLU n 
1 167 VAL n 
1 168 VAL n 
1 169 THR n 
1 170 LEU n 
1 171 TRP n 
1 172 TYR n 
1 173 ARG n 
1 174 ALA n 
1 175 PRO n 
1 176 GLU n 
1 177 ILE n 
1 178 LEU n 
1 179 LEU n 
1 180 GLY n 
1 181 CYS n 
1 182 LYS n 
1 183 TYR n 
1 184 TYR n 
1 185 SER n 
1 186 THR n 
1 187 ALA n 
1 188 VAL n 
1 189 ASP n 
1 190 ILE n 
1 191 TRP n 
1 192 SER n 
1 193 LEU n 
1 194 GLY n 
1 195 CYS n 
1 196 ILE n 
1 197 PHE n 
1 198 ALA n 
1 199 GLU n 
1 200 MET n 
1 201 VAL n 
1 202 THR n 
1 203 ARG n 
1 204 ARG n 
1 205 ALA n 
1 206 LEU n 
1 207 PHE n 
1 208 PRO n 
1 209 GLY n 
1 210 ASP n 
1 211 SER n 
1 212 GLU n 
1 213 ILE n 
1 214 ASP n 
1 215 GLN n 
1 216 LEU n 
1 217 PHE n 
1 218 ARG n 
1 219 ILE n 
1 220 PHE n 
1 221 ARG n 
1 222 THR n 
1 223 LEU n 
1 224 GLY n 
1 225 THR n 
1 226 PRO n 
1 227 ASP n 
1 228 GLU n 
1 229 VAL n 
1 230 VAL n 
1 231 TRP n 
1 232 PRO n 
1 233 GLY n 
1 234 VAL n 
1 235 THR n 
1 236 SER n 
1 237 MET n 
1 238 PRO n 
1 239 ASP n 
1 240 TYR n 
1 241 LYS n 
1 242 PRO n 
1 243 SER n 
1 244 PHE n 
1 245 PRO n 
1 246 LYS n 
1 247 TRP n 
1 248 ALA n 
1 249 ARG n 
1 250 GLN n 
1 251 ASP n 
1 252 PHE n 
1 253 SER n 
1 254 LYS n 
1 255 VAL n 
1 256 VAL n 
1 257 PRO n 
1 258 PRO n 
1 259 LEU n 
1 260 ASP n 
1 261 GLU n 
1 262 ASP n 
1 263 GLY n 
1 264 ARG n 
1 265 SER n 
1 266 LEU n 
1 267 LEU n 
1 268 SER n 
1 269 GLN n 
1 270 MET n 
1 271 LEU n 
1 272 HIS n 
1 273 TYR n 
1 274 ASP n 
1 275 PRO n 
1 276 ASN n 
1 277 LYS n 
1 278 ARG n 
1 279 ILE n 
1 280 SER n 
1 281 ALA n 
1 282 LYS n 
1 283 ALA n 
1 284 ALA n 
1 285 LEU n 
1 286 ALA n 
1 287 HIS n 
1 288 PRO n 
1 289 PHE n 
1 290 PHE n 
1 291 GLN n 
1 292 ASP n 
1 293 VAL n 
1 294 THR n 
1 295 LYS n 
1 296 PRO n 
1 297 VAL n 
1 298 PRO n 
1 299 HIS n 
1 300 LEU n 
1 301 ARG n 
1 302 LEU n 
2 1   GLY n 
2 2   VAL n 
2 3   ASN n 
2 4   GLU n 
2 5   VAL n 
2 6   PRO n 
2 7   ASP n 
2 8   TYR n 
2 9   HIS n 
2 10  GLU n 
2 11  ASP n 
2 12  ILE n 
2 13  HIS n 
2 14  THR n 
2 15  TYR n 
2 16  LEU n 
2 17  ARG n 
2 18  GLU n 
2 19  MET n 
2 20  GLU n 
2 21  VAL n 
2 22  LYS n 
2 23  CYS n 
2 24  LYS n 
2 25  PRO n 
2 26  LYS n 
2 27  VAL n 
2 28  GLY n 
2 29  TYR n 
2 30  MET n 
2 31  LYS n 
2 32  LYS n 
2 33  GLN n 
2 34  PRO n 
2 35  ASP n 
2 36  ILE n 
2 37  THR n 
2 38  ASN n 
2 39  SER n 
2 40  MET n 
2 41  ARG n 
2 42  ALA n 
2 43  ILE n 
2 44  LEU n 
2 45  VAL n 
2 46  ASP n 
2 47  TRP n 
2 48  LEU n 
2 49  VAL n 
2 50  GLU n 
2 51  VAL n 
2 52  GLY n 
2 53  GLU n 
2 54  GLU n 
2 55  TYR n 
2 56  LYS n 
2 57  LEU n 
2 58  GLN n 
2 59  ASN n 
2 60  GLU n 
2 61  THR n 
2 62  LEU n 
2 63  HIS n 
2 64  LEU n 
2 65  ALA n 
2 66  VAL n 
2 67  ASN n 
2 68  TYR n 
2 69  ILE n 
2 70  ASP n 
2 71  ARG n 
2 72  PHE n 
2 73  LEU n 
2 74  SER n 
2 75  SER n 
2 76  MET n 
2 77  SER n 
2 78  VAL n 
2 79  LEU n 
2 80  ARG n 
2 81  GLY n 
2 82  LYS n 
2 83  LEU n 
2 84  GLN n 
2 85  LEU n 
2 86  VAL n 
2 87  GLY n 
2 88  THR n 
2 89  ALA n 
2 90  ALA n 
2 91  MET n 
2 92  LEU n 
2 93  LEU n 
2 94  ALA n 
2 95  SER n 
2 96  LYS n 
2 97  PHE n 
2 98  GLU n 
2 99  GLU n 
2 100 ILE n 
2 101 TYR n 
2 102 PRO n 
2 103 PRO n 
2 104 GLU n 
2 105 VAL n 
2 106 ALA n 
2 107 GLU n 
2 108 PHE n 
2 109 VAL n 
2 110 TYR n 
2 111 ILE n 
2 112 THR n 
2 113 ASP n 
2 114 ASP n 
2 115 THR n 
2 116 TYR n 
2 117 THR n 
2 118 LYS n 
2 119 LYS n 
2 120 GLN n 
2 121 VAL n 
2 122 LEU n 
2 123 ARG n 
2 124 MET n 
2 125 GLU n 
2 126 HIS n 
2 127 LEU n 
2 128 VAL n 
2 129 LEU n 
2 130 LYS n 
2 131 VAL n 
2 132 LEU n 
2 133 ALA n 
2 134 PHE n 
2 135 ASP n 
2 136 LEU n 
2 137 ALA n 
2 138 ALA n 
2 139 PRO n 
2 140 THR n 
2 141 ILE n 
2 142 ASN n 
2 143 GLN n 
2 144 PHE n 
2 145 LEU n 
2 146 THR n 
2 147 GLN n 
2 148 TYR n 
2 149 PHE n 
2 150 LEU n 
2 151 HIS n 
2 152 GLN n 
2 153 GLN n 
2 154 PRO n 
2 155 ALA n 
2 156 ASN n 
2 157 CYS n 
2 158 LYS n 
2 159 VAL n 
2 160 GLU n 
2 161 SER n 
2 162 LEU n 
2 163 ALA n 
2 164 MET n 
2 165 PHE n 
2 166 LEU n 
2 167 GLY n 
2 168 GLU n 
2 169 LEU n 
2 170 SER n 
2 171 LEU n 
2 172 ILE n 
2 173 ASP n 
2 174 ALA n 
2 175 ASP n 
2 176 PRO n 
2 177 TYR n 
2 178 LEU n 
2 179 LYS n 
2 180 TYR n 
2 181 LEU n 
2 182 PRO n 
2 183 SER n 
2 184 VAL n 
2 185 ILE n 
2 186 ALA n 
2 187 ALA n 
2 188 ALA n 
2 189 ALA n 
2 190 PHE n 
2 191 HIS n 
2 192 LEU n 
2 193 ALA n 
2 194 LEU n 
2 195 TYR n 
2 196 THR n 
2 197 VAL n 
2 198 THR n 
2 199 GLY n 
2 200 GLN n 
2 201 SER n 
2 202 TRP n 
2 203 PRO n 
2 204 GLU n 
2 205 SER n 
2 206 LEU n 
2 207 VAL n 
2 208 GLN n 
2 209 LYS n 
2 210 THR n 
2 211 GLY n 
2 212 TYR n 
2 213 THR n 
2 214 LEU n 
2 215 GLU n 
2 216 THR n 
2 217 LEU n 
2 218 LYS n 
2 219 PRO n 
2 220 CYS n 
2 221 LEU n 
2 222 LEU n 
2 223 ASP n 
2 224 LEU n 
2 225 HIS n 
2 226 GLN n 
2 227 THR n 
2 228 TYR n 
2 229 LEU n 
2 230 ARG n 
2 231 ALA n 
2 232 PRO n 
2 233 GLN n 
2 234 HIS n 
2 235 ALA n 
2 236 GLN n 
2 237 GLN n 
2 238 SER n 
2 239 ILE n 
2 240 ARG n 
2 241 GLU n 
2 242 LYS n 
2 243 TYR n 
2 244 LYS n 
2 245 ASN n 
2 246 SER n 
2 247 LYS n 
2 248 TYR n 
2 249 HIS n 
2 250 GLY n 
2 251 VAL n 
2 252 SER n 
2 253 LEU n 
2 254 LEU n 
2 255 ASN n 
2 256 PRO n 
2 257 PRO n 
2 258 GLU n 
2 259 THR n 
2 260 LEU n 
2 261 ASN n 
2 262 VAL n 
2 263 HIS n 
2 264 HIS n 
2 265 HIS n 
2 266 HIS n 
2 267 HIS n 
2 268 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 302 human  ? 'CDK2, CDKN2' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? PGEX6P1 ? ? 
2 1 sample 'Biological sequence' 1 268 cattle ? CCNA2         ? ? ? ? ? ? 'Bos taurus'   9913 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? PET21d  ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                        ?                  'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                       ?                  'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                     ?                  'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                ?                  'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                       ?                  'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                      ?                  'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                ?                  'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                        ?                  'C2 H5 N O2'     75.067  
HHT non-polymer         . '2-(4-bromanyl-2-methoxy-phenyl)ethanoic acid' ?                  'C9 H9 Br O3'    245.070 
HIS 'L-peptide linking' y HISTIDINE                                      ?                  'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                          ?                  'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                     ?                  'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                        ?                  'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                         ?                  'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                     ?                  'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                  ?                  'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                        ?                  'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                         ?                  'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                      ?                  'C4 H9 N O3'     119.119 
TPO 'L-peptide linking' n PHOSPHOTHREONINE                               PHOSPHONOTHREONINE 'C4 H10 N O6 P'  199.099 
TRP 'L-peptide linking' y TRYPTOPHAN                                     ?                  'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                       ?                  'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                         ?                  'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -3  -3  GLY GLY A . n 
A 1 2   PRO 2   -2  -2  PRO PRO A . n 
A 1 3   GLY 3   -1  -1  GLY GLY A . n 
A 1 4   SER 4   0   0   SER SER A . n 
A 1 5   MET 5   1   1   MET MET A . n 
A 1 6   GLU 6   2   2   GLU GLU A . n 
A 1 7   ASN 7   3   3   ASN ASN A . n 
A 1 8   PHE 8   4   4   PHE PHE A . n 
A 1 9   GLN 9   5   5   GLN GLN A . n 
A 1 10  LYS 10  6   6   LYS LYS A . n 
A 1 11  VAL 11  7   7   VAL VAL A . n 
A 1 12  GLU 12  8   8   GLU GLU A . n 
A 1 13  LYS 13  9   9   LYS LYS A . n 
A 1 14  ILE 14  10  10  ILE ILE A . n 
A 1 15  GLY 15  11  11  GLY GLY A . n 
A 1 16  GLU 16  12  12  GLU GLU A . n 
A 1 17  GLY 17  13  13  GLY GLY A . n 
A 1 18  THR 18  14  14  THR THR A . n 
A 1 19  TYR 19  15  15  TYR TYR A . n 
A 1 20  GLY 20  16  16  GLY GLY A . n 
A 1 21  VAL 21  17  17  VAL VAL A . n 
A 1 22  VAL 22  18  18  VAL VAL A . n 
A 1 23  TYR 23  19  19  TYR TYR A . n 
A 1 24  LYS 24  20  20  LYS LYS A . n 
A 1 25  ALA 25  21  21  ALA ALA A . n 
A 1 26  ARG 26  22  22  ARG ARG A . n 
A 1 27  ASN 27  23  23  ASN ASN A . n 
A 1 28  LYS 28  24  24  LYS LYS A . n 
A 1 29  LEU 29  25  25  LEU LEU A . n 
A 1 30  THR 30  26  26  THR THR A . n 
A 1 31  GLY 31  27  27  GLY GLY A . n 
A 1 32  GLU 32  28  28  GLU GLU A . n 
A 1 33  VAL 33  29  29  VAL VAL A . n 
A 1 34  VAL 34  30  30  VAL VAL A . n 
A 1 35  ALA 35  31  31  ALA ALA A . n 
A 1 36  LEU 36  32  32  LEU LEU A . n 
A 1 37  LYS 37  33  33  LYS LYS A . n 
A 1 38  LYS 38  34  34  LYS LYS A . n 
A 1 39  ILE 39  35  35  ILE ILE A . n 
A 1 40  ARG 40  36  36  ARG ARG A . n 
A 1 41  LEU 41  37  37  LEU LEU A . n 
A 1 42  ASP 42  38  38  ASP ASP A . n 
A 1 43  THR 43  39  39  THR THR A . n 
A 1 44  GLU 44  40  40  GLU GLU A . n 
A 1 45  THR 45  41  41  THR THR A . n 
A 1 46  GLU 46  42  42  GLU GLU A . n 
A 1 47  GLY 47  43  43  GLY GLY A . n 
A 1 48  VAL 48  44  44  VAL VAL A . n 
A 1 49  PRO 49  45  45  PRO PRO A . n 
A 1 50  SER 50  46  46  SER SER A . n 
A 1 51  THR 51  47  47  THR THR A . n 
A 1 52  ALA 52  48  48  ALA ALA A . n 
A 1 53  ILE 53  49  49  ILE ILE A . n 
A 1 54  ARG 54  50  50  ARG ARG A . n 
A 1 55  GLU 55  51  51  GLU GLU A . n 
A 1 56  ILE 56  52  52  ILE ILE A . n 
A 1 57  SER 57  53  53  SER SER A . n 
A 1 58  LEU 58  54  54  LEU LEU A . n 
A 1 59  LEU 59  55  55  LEU LEU A . n 
A 1 60  LYS 60  56  56  LYS LYS A . n 
A 1 61  GLU 61  57  57  GLU GLU A . n 
A 1 62  LEU 62  58  58  LEU LEU A . n 
A 1 63  ASN 63  59  59  ASN ASN A . n 
A 1 64  HIS 64  60  60  HIS HIS A . n 
A 1 65  PRO 65  61  61  PRO PRO A . n 
A 1 66  ASN 66  62  62  ASN ASN A . n 
A 1 67  ILE 67  63  63  ILE ILE A . n 
A 1 68  VAL 68  64  64  VAL VAL A . n 
A 1 69  LYS 69  65  65  LYS LYS A . n 
A 1 70  LEU 70  66  66  LEU LEU A . n 
A 1 71  LEU 71  67  67  LEU LEU A . n 
A 1 72  ASP 72  68  68  ASP ASP A . n 
A 1 73  VAL 73  69  69  VAL VAL A . n 
A 1 74  ILE 74  70  70  ILE ILE A . n 
A 1 75  HIS 75  71  71  HIS HIS A . n 
A 1 76  THR 76  72  72  THR THR A . n 
A 1 77  GLU 77  73  73  GLU GLU A . n 
A 1 78  ASN 78  74  74  ASN ASN A . n 
A 1 79  LYS 79  75  75  LYS LYS A . n 
A 1 80  LEU 80  76  76  LEU LEU A . n 
A 1 81  TYR 81  77  77  TYR TYR A . n 
A 1 82  LEU 82  78  78  LEU LEU A . n 
A 1 83  VAL 83  79  79  VAL VAL A . n 
A 1 84  PHE 84  80  80  PHE PHE A . n 
A 1 85  GLU 85  81  81  GLU GLU A . n 
A 1 86  PHE 86  82  82  PHE PHE A . n 
A 1 87  LEU 87  83  83  LEU LEU A . n 
A 1 88  HIS 88  84  84  HIS HIS A . n 
A 1 89  GLN 89  85  85  GLN GLN A . n 
A 1 90  ASP 90  86  86  ASP ASP A . n 
A 1 91  LEU 91  87  87  LEU LEU A . n 
A 1 92  LYS 92  88  88  LYS LYS A . n 
A 1 93  LYS 93  89  89  LYS LYS A . n 
A 1 94  PHE 94  90  90  PHE PHE A . n 
A 1 95  MET 95  91  91  MET MET A . n 
A 1 96  ASP 96  92  92  ASP ASP A . n 
A 1 97  ALA 97  93  93  ALA ALA A . n 
A 1 98  SER 98  94  94  SER SER A . n 
A 1 99  ALA 99  95  95  ALA ALA A . n 
A 1 100 LEU 100 96  96  LEU LEU A . n 
A 1 101 THR 101 97  97  THR THR A . n 
A 1 102 GLY 102 98  98  GLY GLY A . n 
A 1 103 ILE 103 99  99  ILE ILE A . n 
A 1 104 PRO 104 100 100 PRO PRO A . n 
A 1 105 LEU 105 101 101 LEU LEU A . n 
A 1 106 PRO 106 102 102 PRO PRO A . n 
A 1 107 LEU 107 103 103 LEU LEU A . n 
A 1 108 ILE 108 104 104 ILE ILE A . n 
A 1 109 LYS 109 105 105 LYS LYS A . n 
A 1 110 SER 110 106 106 SER SER A . n 
A 1 111 TYR 111 107 107 TYR TYR A . n 
A 1 112 LEU 112 108 108 LEU LEU A . n 
A 1 113 PHE 113 109 109 PHE PHE A . n 
A 1 114 GLN 114 110 110 GLN GLN A . n 
A 1 115 LEU 115 111 111 LEU LEU A . n 
A 1 116 LEU 116 112 112 LEU LEU A . n 
A 1 117 GLN 117 113 113 GLN GLN A . n 
A 1 118 GLY 118 114 114 GLY GLY A . n 
A 1 119 LEU 119 115 115 LEU LEU A . n 
A 1 120 ALA 120 116 116 ALA ALA A . n 
A 1 121 PHE 121 117 117 PHE PHE A . n 
A 1 122 CYS 122 118 118 CYS CYS A . n 
A 1 123 HIS 123 119 119 HIS HIS A . n 
A 1 124 SER 124 120 120 SER SER A . n 
A 1 125 HIS 125 121 121 HIS HIS A . n 
A 1 126 ARG 126 122 122 ARG ARG A . n 
A 1 127 VAL 127 123 123 VAL VAL A . n 
A 1 128 LEU 128 124 124 LEU LEU A . n 
A 1 129 HIS 129 125 125 HIS HIS A . n 
A 1 130 ARG 130 126 126 ARG ARG A . n 
A 1 131 ASP 131 127 127 ASP ASP A . n 
A 1 132 LEU 132 128 128 LEU LEU A . n 
A 1 133 LYS 133 129 129 LYS LYS A . n 
A 1 134 PRO 134 130 130 PRO PRO A . n 
A 1 135 GLN 135 131 131 GLN GLN A . n 
A 1 136 ASN 136 132 132 ASN ASN A . n 
A 1 137 LEU 137 133 133 LEU LEU A . n 
A 1 138 LEU 138 134 134 LEU LEU A . n 
A 1 139 ILE 139 135 135 ILE ILE A . n 
A 1 140 ASN 140 136 136 ASN ASN A . n 
A 1 141 THR 141 137 137 THR THR A . n 
A 1 142 GLU 142 138 138 GLU GLU A . n 
A 1 143 GLY 143 139 139 GLY GLY A . n 
A 1 144 ALA 144 140 140 ALA ALA A . n 
A 1 145 ILE 145 141 141 ILE ILE A . n 
A 1 146 LYS 146 142 142 LYS LYS A . n 
A 1 147 LEU 147 143 143 LEU LEU A . n 
A 1 148 ALA 148 144 144 ALA ALA A . n 
A 1 149 ASP 149 145 145 ASP ASP A . n 
A 1 150 PHE 150 146 146 PHE PHE A . n 
A 1 151 GLY 151 147 147 GLY GLY A . n 
A 1 152 LEU 152 148 148 LEU LEU A . n 
A 1 153 ALA 153 149 149 ALA ALA A . n 
A 1 154 ARG 154 150 150 ARG ARG A . n 
A 1 155 ALA 155 151 151 ALA ALA A . n 
A 1 156 PHE 156 152 152 PHE PHE A . n 
A 1 157 GLY 157 153 153 GLY GLY A . n 
A 1 158 VAL 158 154 154 VAL VAL A . n 
A 1 159 PRO 159 155 155 PRO PRO A . n 
A 1 160 VAL 160 156 156 VAL VAL A . n 
A 1 161 ARG 161 157 157 ARG ARG A . n 
A 1 162 THR 162 158 158 THR THR A . n 
A 1 163 TYR 163 159 159 TYR TYR A . n 
A 1 164 TPO 164 160 160 TPO TPO A . n 
A 1 165 HIS 165 161 161 HIS HIS A . n 
A 1 166 GLU 166 162 162 GLU GLU A . n 
A 1 167 VAL 167 163 163 VAL VAL A . n 
A 1 168 VAL 168 164 164 VAL VAL A . n 
A 1 169 THR 169 165 165 THR THR A . n 
A 1 170 LEU 170 166 166 LEU LEU A . n 
A 1 171 TRP 171 167 167 TRP TRP A . n 
A 1 172 TYR 172 168 168 TYR TYR A . n 
A 1 173 ARG 173 169 169 ARG ARG A . n 
A 1 174 ALA 174 170 170 ALA ALA A . n 
A 1 175 PRO 175 171 171 PRO PRO A . n 
A 1 176 GLU 176 172 172 GLU GLU A . n 
A 1 177 ILE 177 173 173 ILE ILE A . n 
A 1 178 LEU 178 174 174 LEU LEU A . n 
A 1 179 LEU 179 175 175 LEU LEU A . n 
A 1 180 GLY 180 176 176 GLY GLY A . n 
A 1 181 CYS 181 177 177 CYS CYS A . n 
A 1 182 LYS 182 178 178 LYS LYS A . n 
A 1 183 TYR 183 179 179 TYR TYR A . n 
A 1 184 TYR 184 180 180 TYR TYR A . n 
A 1 185 SER 185 181 181 SER SER A . n 
A 1 186 THR 186 182 182 THR THR A . n 
A 1 187 ALA 187 183 183 ALA ALA A . n 
A 1 188 VAL 188 184 184 VAL VAL A . n 
A 1 189 ASP 189 185 185 ASP ASP A . n 
A 1 190 ILE 190 186 186 ILE ILE A . n 
A 1 191 TRP 191 187 187 TRP TRP A . n 
A 1 192 SER 192 188 188 SER SER A . n 
A 1 193 LEU 193 189 189 LEU LEU A . n 
A 1 194 GLY 194 190 190 GLY GLY A . n 
A 1 195 CYS 195 191 191 CYS CYS A . n 
A 1 196 ILE 196 192 192 ILE ILE A . n 
A 1 197 PHE 197 193 193 PHE PHE A . n 
A 1 198 ALA 198 194 194 ALA ALA A . n 
A 1 199 GLU 199 195 195 GLU GLU A . n 
A 1 200 MET 200 196 196 MET MET A . n 
A 1 201 VAL 201 197 197 VAL VAL A . n 
A 1 202 THR 202 198 198 THR THR A . n 
A 1 203 ARG 203 199 199 ARG ARG A . n 
A 1 204 ARG 204 200 200 ARG ARG A . n 
A 1 205 ALA 205 201 201 ALA ALA A . n 
A 1 206 LEU 206 202 202 LEU LEU A . n 
A 1 207 PHE 207 203 203 PHE PHE A . n 
A 1 208 PRO 208 204 204 PRO PRO A . n 
A 1 209 GLY 209 205 205 GLY GLY A . n 
A 1 210 ASP 210 206 206 ASP ASP A . n 
A 1 211 SER 211 207 207 SER SER A . n 
A 1 212 GLU 212 208 208 GLU GLU A . n 
A 1 213 ILE 213 209 209 ILE ILE A . n 
A 1 214 ASP 214 210 210 ASP ASP A . n 
A 1 215 GLN 215 211 211 GLN GLN A . n 
A 1 216 LEU 216 212 212 LEU LEU A . n 
A 1 217 PHE 217 213 213 PHE PHE A . n 
A 1 218 ARG 218 214 214 ARG ARG A . n 
A 1 219 ILE 219 215 215 ILE ILE A . n 
A 1 220 PHE 220 216 216 PHE PHE A . n 
A 1 221 ARG 221 217 217 ARG ARG A . n 
A 1 222 THR 222 218 218 THR THR A . n 
A 1 223 LEU 223 219 219 LEU LEU A . n 
A 1 224 GLY 224 220 220 GLY GLY A . n 
A 1 225 THR 225 221 221 THR THR A . n 
A 1 226 PRO 226 222 222 PRO PRO A . n 
A 1 227 ASP 227 223 223 ASP ASP A . n 
A 1 228 GLU 228 224 224 GLU GLU A . n 
A 1 229 VAL 229 225 225 VAL VAL A . n 
A 1 230 VAL 230 226 226 VAL VAL A . n 
A 1 231 TRP 231 227 227 TRP TRP A . n 
A 1 232 PRO 232 228 228 PRO PRO A . n 
A 1 233 GLY 233 229 229 GLY GLY A . n 
A 1 234 VAL 234 230 230 VAL VAL A . n 
A 1 235 THR 235 231 231 THR THR A . n 
A 1 236 SER 236 232 232 SER SER A . n 
A 1 237 MET 237 233 233 MET MET A . n 
A 1 238 PRO 238 234 234 PRO PRO A . n 
A 1 239 ASP 239 235 235 ASP ASP A . n 
A 1 240 TYR 240 236 236 TYR TYR A . n 
A 1 241 LYS 241 237 237 LYS LYS A . n 
A 1 242 PRO 242 238 238 PRO PRO A . n 
A 1 243 SER 243 239 239 SER SER A . n 
A 1 244 PHE 244 240 240 PHE PHE A . n 
A 1 245 PRO 245 241 241 PRO PRO A . n 
A 1 246 LYS 246 242 242 LYS LYS A . n 
A 1 247 TRP 247 243 243 TRP TRP A . n 
A 1 248 ALA 248 244 244 ALA ALA A . n 
A 1 249 ARG 249 245 245 ARG ARG A . n 
A 1 250 GLN 250 246 246 GLN GLN A . n 
A 1 251 ASP 251 247 247 ASP ASP A . n 
A 1 252 PHE 252 248 248 PHE PHE A . n 
A 1 253 SER 253 249 249 SER SER A . n 
A 1 254 LYS 254 250 250 LYS LYS A . n 
A 1 255 VAL 255 251 251 VAL VAL A . n 
A 1 256 VAL 256 252 252 VAL VAL A . n 
A 1 257 PRO 257 253 253 PRO PRO A . n 
A 1 258 PRO 258 254 254 PRO PRO A . n 
A 1 259 LEU 259 255 255 LEU LEU A . n 
A 1 260 ASP 260 256 256 ASP ASP A . n 
A 1 261 GLU 261 257 257 GLU GLU A . n 
A 1 262 ASP 262 258 258 ASP ASP A . n 
A 1 263 GLY 263 259 259 GLY GLY A . n 
A 1 264 ARG 264 260 260 ARG ARG A . n 
A 1 265 SER 265 261 261 SER SER A . n 
A 1 266 LEU 266 262 262 LEU LEU A . n 
A 1 267 LEU 267 263 263 LEU LEU A . n 
A 1 268 SER 268 264 264 SER SER A . n 
A 1 269 GLN 269 265 265 GLN GLN A . n 
A 1 270 MET 270 266 266 MET MET A . n 
A 1 271 LEU 271 267 267 LEU LEU A . n 
A 1 272 HIS 272 268 268 HIS HIS A . n 
A 1 273 TYR 273 269 269 TYR TYR A . n 
A 1 274 ASP 274 270 270 ASP ASP A . n 
A 1 275 PRO 275 271 271 PRO PRO A . n 
A 1 276 ASN 276 272 272 ASN ASN A . n 
A 1 277 LYS 277 273 273 LYS LYS A . n 
A 1 278 ARG 278 274 274 ARG ARG A . n 
A 1 279 ILE 279 275 275 ILE ILE A . n 
A 1 280 SER 280 276 276 SER SER A . n 
A 1 281 ALA 281 277 277 ALA ALA A . n 
A 1 282 LYS 282 278 278 LYS LYS A . n 
A 1 283 ALA 283 279 279 ALA ALA A . n 
A 1 284 ALA 284 280 280 ALA ALA A . n 
A 1 285 LEU 285 281 281 LEU LEU A . n 
A 1 286 ALA 286 282 282 ALA ALA A . n 
A 1 287 HIS 287 283 283 HIS HIS A . n 
A 1 288 PRO 288 284 284 PRO PRO A . n 
A 1 289 PHE 289 285 285 PHE PHE A . n 
A 1 290 PHE 290 286 286 PHE PHE A . n 
A 1 291 GLN 291 287 287 GLN GLN A . n 
A 1 292 ASP 292 288 288 ASP ASP A . n 
A 1 293 VAL 293 289 289 VAL VAL A . n 
A 1 294 THR 294 290 290 THR THR A . n 
A 1 295 LYS 295 291 291 LYS LYS A . n 
A 1 296 PRO 296 292 292 PRO PRO A . n 
A 1 297 VAL 297 293 293 VAL VAL A . n 
A 1 298 PRO 298 294 294 PRO PRO A . n 
A 1 299 HIS 299 295 295 HIS HIS A . n 
A 1 300 LEU 300 296 296 LEU LEU A . n 
A 1 301 ARG 301 297 ?   ?   ?   A . n 
A 1 302 LEU 302 298 ?   ?   ?   A . n 
B 2 1   GLY 1   171 171 GLY GLY B . n 
B 2 2   VAL 2   172 172 VAL VAL B . n 
B 2 3   ASN 3   173 173 ASN ASN B . n 
B 2 4   GLU 4   174 174 GLU GLU B . n 
B 2 5   VAL 5   175 175 VAL VAL B . n 
B 2 6   PRO 6   176 176 PRO PRO B . n 
B 2 7   ASP 7   177 177 ASP ASP B . n 
B 2 8   TYR 8   178 178 TYR TYR B . n 
B 2 9   HIS 9   179 179 HIS HIS B . n 
B 2 10  GLU 10  180 180 GLU GLU B . n 
B 2 11  ASP 11  181 181 ASP ASP B . n 
B 2 12  ILE 12  182 182 ILE ILE B . n 
B 2 13  HIS 13  183 183 HIS HIS B . n 
B 2 14  THR 14  184 184 THR THR B . n 
B 2 15  TYR 15  185 185 TYR TYR B . n 
B 2 16  LEU 16  186 186 LEU LEU B . n 
B 2 17  ARG 17  187 187 ARG ARG B . n 
B 2 18  GLU 18  188 188 GLU GLU B . n 
B 2 19  MET 19  189 189 MET MET B . n 
B 2 20  GLU 20  190 190 GLU GLU B . n 
B 2 21  VAL 21  191 191 VAL VAL B . n 
B 2 22  LYS 22  192 192 LYS LYS B . n 
B 2 23  CYS 23  193 193 CYS CYS B . n 
B 2 24  LYS 24  194 194 LYS LYS B . n 
B 2 25  PRO 25  195 195 PRO PRO B . n 
B 2 26  LYS 26  196 196 LYS LYS B . n 
B 2 27  VAL 27  197 197 VAL VAL B . n 
B 2 28  GLY 28  198 198 GLY GLY B . n 
B 2 29  TYR 29  199 199 TYR TYR B . n 
B 2 30  MET 30  200 200 MET MET B . n 
B 2 31  LYS 31  201 201 LYS LYS B . n 
B 2 32  LYS 32  202 202 LYS LYS B . n 
B 2 33  GLN 33  203 203 GLN GLN B . n 
B 2 34  PRO 34  204 204 PRO PRO B . n 
B 2 35  ASP 35  205 205 ASP ASP B . n 
B 2 36  ILE 36  206 206 ILE ILE B . n 
B 2 37  THR 37  207 207 THR THR B . n 
B 2 38  ASN 38  208 208 ASN ASN B . n 
B 2 39  SER 39  209 209 SER SER B . n 
B 2 40  MET 40  210 210 MET MET B . n 
B 2 41  ARG 41  211 211 ARG ARG B . n 
B 2 42  ALA 42  212 212 ALA ALA B . n 
B 2 43  ILE 43  213 213 ILE ILE B . n 
B 2 44  LEU 44  214 214 LEU LEU B . n 
B 2 45  VAL 45  215 215 VAL VAL B . n 
B 2 46  ASP 46  216 216 ASP ASP B . n 
B 2 47  TRP 47  217 217 TRP TRP B . n 
B 2 48  LEU 48  218 218 LEU LEU B . n 
B 2 49  VAL 49  219 219 VAL VAL B . n 
B 2 50  GLU 50  220 220 GLU GLU B . n 
B 2 51  VAL 51  221 221 VAL VAL B . n 
B 2 52  GLY 52  222 222 GLY GLY B . n 
B 2 53  GLU 53  223 223 GLU GLU B . n 
B 2 54  GLU 54  224 224 GLU GLU B . n 
B 2 55  TYR 55  225 225 TYR TYR B . n 
B 2 56  LYS 56  226 226 LYS LYS B . n 
B 2 57  LEU 57  227 227 LEU LEU B . n 
B 2 58  GLN 58  228 228 GLN GLN B . n 
B 2 59  ASN 59  229 229 ASN ASN B . n 
B 2 60  GLU 60  230 230 GLU GLU B . n 
B 2 61  THR 61  231 231 THR THR B . n 
B 2 62  LEU 62  232 232 LEU LEU B . n 
B 2 63  HIS 63  233 233 HIS HIS B . n 
B 2 64  LEU 64  234 234 LEU LEU B . n 
B 2 65  ALA 65  235 235 ALA ALA B . n 
B 2 66  VAL 66  236 236 VAL VAL B . n 
B 2 67  ASN 67  237 237 ASN ASN B . n 
B 2 68  TYR 68  238 238 TYR TYR B . n 
B 2 69  ILE 69  239 239 ILE ILE B . n 
B 2 70  ASP 70  240 240 ASP ASP B . n 
B 2 71  ARG 71  241 241 ARG ARG B . n 
B 2 72  PHE 72  242 242 PHE PHE B . n 
B 2 73  LEU 73  243 243 LEU LEU B . n 
B 2 74  SER 74  244 244 SER SER B . n 
B 2 75  SER 75  245 245 SER SER B . n 
B 2 76  MET 76  246 246 MET MET B . n 
B 2 77  SER 77  247 247 SER SER B . n 
B 2 78  VAL 78  248 248 VAL VAL B . n 
B 2 79  LEU 79  249 249 LEU LEU B . n 
B 2 80  ARG 80  250 250 ARG ARG B . n 
B 2 81  GLY 81  251 251 GLY GLY B . n 
B 2 82  LYS 82  252 252 LYS LYS B . n 
B 2 83  LEU 83  253 253 LEU LEU B . n 
B 2 84  GLN 84  254 254 GLN GLN B . n 
B 2 85  LEU 85  255 255 LEU LEU B . n 
B 2 86  VAL 86  256 256 VAL VAL B . n 
B 2 87  GLY 87  257 257 GLY GLY B . n 
B 2 88  THR 88  258 258 THR THR B . n 
B 2 89  ALA 89  259 259 ALA ALA B . n 
B 2 90  ALA 90  260 260 ALA ALA B . n 
B 2 91  MET 91  261 261 MET MET B . n 
B 2 92  LEU 92  262 262 LEU LEU B . n 
B 2 93  LEU 93  263 263 LEU LEU B . n 
B 2 94  ALA 94  264 264 ALA ALA B . n 
B 2 95  SER 95  265 265 SER SER B . n 
B 2 96  LYS 96  266 266 LYS LYS B . n 
B 2 97  PHE 97  267 267 PHE PHE B . n 
B 2 98  GLU 98  268 268 GLU GLU B . n 
B 2 99  GLU 99  269 269 GLU GLU B . n 
B 2 100 ILE 100 270 270 ILE ILE B . n 
B 2 101 TYR 101 271 271 TYR TYR B . n 
B 2 102 PRO 102 272 272 PRO PRO B . n 
B 2 103 PRO 103 273 273 PRO PRO B . n 
B 2 104 GLU 104 274 274 GLU GLU B . n 
B 2 105 VAL 105 275 275 VAL VAL B . n 
B 2 106 ALA 106 276 276 ALA ALA B . n 
B 2 107 GLU 107 277 277 GLU GLU B . n 
B 2 108 PHE 108 278 278 PHE PHE B . n 
B 2 109 VAL 109 279 279 VAL VAL B . n 
B 2 110 TYR 110 280 280 TYR TYR B . n 
B 2 111 ILE 111 281 281 ILE ILE B . n 
B 2 112 THR 112 282 282 THR THR B . n 
B 2 113 ASP 113 283 283 ASP ASP B . n 
B 2 114 ASP 114 284 284 ASP ASP B . n 
B 2 115 THR 115 285 285 THR THR B . n 
B 2 116 TYR 116 286 286 TYR TYR B . n 
B 2 117 THR 117 287 287 THR THR B . n 
B 2 118 LYS 118 288 288 LYS LYS B . n 
B 2 119 LYS 119 289 289 LYS LYS B . n 
B 2 120 GLN 120 290 290 GLN GLN B . n 
B 2 121 VAL 121 291 291 VAL VAL B . n 
B 2 122 LEU 122 292 292 LEU LEU B . n 
B 2 123 ARG 123 293 293 ARG ARG B . n 
B 2 124 MET 124 294 294 MET MET B . n 
B 2 125 GLU 125 295 295 GLU GLU B . n 
B 2 126 HIS 126 296 296 HIS HIS B . n 
B 2 127 LEU 127 297 297 LEU LEU B . n 
B 2 128 VAL 128 298 298 VAL VAL B . n 
B 2 129 LEU 129 299 299 LEU LEU B . n 
B 2 130 LYS 130 300 300 LYS LYS B . n 
B 2 131 VAL 131 301 301 VAL VAL B . n 
B 2 132 LEU 132 302 302 LEU LEU B . n 
B 2 133 ALA 133 303 303 ALA ALA B . n 
B 2 134 PHE 134 304 304 PHE PHE B . n 
B 2 135 ASP 135 305 305 ASP ASP B . n 
B 2 136 LEU 136 306 306 LEU LEU B . n 
B 2 137 ALA 137 307 307 ALA ALA B . n 
B 2 138 ALA 138 308 308 ALA ALA B . n 
B 2 139 PRO 139 309 309 PRO PRO B . n 
B 2 140 THR 140 310 310 THR THR B . n 
B 2 141 ILE 141 311 311 ILE ILE B . n 
B 2 142 ASN 142 312 312 ASN ASN B . n 
B 2 143 GLN 143 313 313 GLN GLN B . n 
B 2 144 PHE 144 314 314 PHE PHE B . n 
B 2 145 LEU 145 315 315 LEU LEU B . n 
B 2 146 THR 146 316 316 THR THR B . n 
B 2 147 GLN 147 317 317 GLN GLN B . n 
B 2 148 TYR 148 318 318 TYR TYR B . n 
B 2 149 PHE 149 319 319 PHE PHE B . n 
B 2 150 LEU 150 320 320 LEU LEU B . n 
B 2 151 HIS 151 321 321 HIS HIS B . n 
B 2 152 GLN 152 322 322 GLN GLN B . n 
B 2 153 GLN 153 323 323 GLN GLN B . n 
B 2 154 PRO 154 324 324 PRO PRO B . n 
B 2 155 ALA 155 325 325 ALA ALA B . n 
B 2 156 ASN 156 326 326 ASN ASN B . n 
B 2 157 CYS 157 327 327 CYS CYS B . n 
B 2 158 LYS 158 328 328 LYS LYS B . n 
B 2 159 VAL 159 329 329 VAL VAL B . n 
B 2 160 GLU 160 330 330 GLU GLU B . n 
B 2 161 SER 161 331 331 SER SER B . n 
B 2 162 LEU 162 332 332 LEU LEU B . n 
B 2 163 ALA 163 333 333 ALA ALA B . n 
B 2 164 MET 164 334 334 MET MET B . n 
B 2 165 PHE 165 335 335 PHE PHE B . n 
B 2 166 LEU 166 336 336 LEU LEU B . n 
B 2 167 GLY 167 337 337 GLY GLY B . n 
B 2 168 GLU 168 338 338 GLU GLU B . n 
B 2 169 LEU 169 339 339 LEU LEU B . n 
B 2 170 SER 170 340 340 SER SER B . n 
B 2 171 LEU 171 341 341 LEU LEU B . n 
B 2 172 ILE 172 342 342 ILE ILE B . n 
B 2 173 ASP 173 343 343 ASP ASP B . n 
B 2 174 ALA 174 344 344 ALA ALA B . n 
B 2 175 ASP 175 345 345 ASP ASP B . n 
B 2 176 PRO 176 346 346 PRO PRO B . n 
B 2 177 TYR 177 347 347 TYR TYR B . n 
B 2 178 LEU 178 348 348 LEU LEU B . n 
B 2 179 LYS 179 349 349 LYS LYS B . n 
B 2 180 TYR 180 350 350 TYR TYR B . n 
B 2 181 LEU 181 351 351 LEU LEU B . n 
B 2 182 PRO 182 352 352 PRO PRO B . n 
B 2 183 SER 183 353 353 SER SER B . n 
B 2 184 VAL 184 354 354 VAL VAL B . n 
B 2 185 ILE 185 355 355 ILE ILE B . n 
B 2 186 ALA 186 356 356 ALA ALA B . n 
B 2 187 ALA 187 357 357 ALA ALA B . n 
B 2 188 ALA 188 358 358 ALA ALA B . n 
B 2 189 ALA 189 359 359 ALA ALA B . n 
B 2 190 PHE 190 360 360 PHE PHE B . n 
B 2 191 HIS 191 361 361 HIS HIS B . n 
B 2 192 LEU 192 362 362 LEU LEU B . n 
B 2 193 ALA 193 363 363 ALA ALA B . n 
B 2 194 LEU 194 364 364 LEU LEU B . n 
B 2 195 TYR 195 365 365 TYR TYR B . n 
B 2 196 THR 196 366 366 THR THR B . n 
B 2 197 VAL 197 367 367 VAL VAL B . n 
B 2 198 THR 198 368 368 THR THR B . n 
B 2 199 GLY 199 369 369 GLY GLY B . n 
B 2 200 GLN 200 370 370 GLN GLN B . n 
B 2 201 SER 201 371 371 SER SER B . n 
B 2 202 TRP 202 372 372 TRP TRP B . n 
B 2 203 PRO 203 373 373 PRO PRO B . n 
B 2 204 GLU 204 374 374 GLU GLU B . n 
B 2 205 SER 205 375 375 SER SER B . n 
B 2 206 LEU 206 376 376 LEU LEU B . n 
B 2 207 VAL 207 377 377 VAL VAL B . n 
B 2 208 GLN 208 378 378 GLN GLN B . n 
B 2 209 LYS 209 379 379 LYS LYS B . n 
B 2 210 THR 210 380 380 THR THR B . n 
B 2 211 GLY 211 381 381 GLY GLY B . n 
B 2 212 TYR 212 382 382 TYR TYR B . n 
B 2 213 THR 213 383 383 THR THR B . n 
B 2 214 LEU 214 384 384 LEU LEU B . n 
B 2 215 GLU 215 385 385 GLU GLU B . n 
B 2 216 THR 216 386 386 THR THR B . n 
B 2 217 LEU 217 387 387 LEU LEU B . n 
B 2 218 LYS 218 388 388 LYS LYS B . n 
B 2 219 PRO 219 389 389 PRO PRO B . n 
B 2 220 CYS 220 390 390 CYS CYS B . n 
B 2 221 LEU 221 391 391 LEU LEU B . n 
B 2 222 LEU 222 392 392 LEU LEU B . n 
B 2 223 ASP 223 393 393 ASP ASP B . n 
B 2 224 LEU 224 394 394 LEU LEU B . n 
B 2 225 HIS 225 395 395 HIS HIS B . n 
B 2 226 GLN 226 396 396 GLN GLN B . n 
B 2 227 THR 227 397 397 THR THR B . n 
B 2 228 TYR 228 398 398 TYR TYR B . n 
B 2 229 LEU 229 399 399 LEU LEU B . n 
B 2 230 ARG 230 400 400 ARG ARG B . n 
B 2 231 ALA 231 401 401 ALA ALA B . n 
B 2 232 PRO 232 402 402 PRO PRO B . n 
B 2 233 GLN 233 403 403 GLN GLN B . n 
B 2 234 HIS 234 404 404 HIS HIS B . n 
B 2 235 ALA 235 405 405 ALA ALA B . n 
B 2 236 GLN 236 406 406 GLN GLN B . n 
B 2 237 GLN 237 407 407 GLN GLN B . n 
B 2 238 SER 238 408 408 SER SER B . n 
B 2 239 ILE 239 409 409 ILE ILE B . n 
B 2 240 ARG 240 410 410 ARG ARG B . n 
B 2 241 GLU 241 411 411 GLU GLU B . n 
B 2 242 LYS 242 412 412 LYS LYS B . n 
B 2 243 TYR 243 413 413 TYR TYR B . n 
B 2 244 LYS 244 414 414 LYS LYS B . n 
B 2 245 ASN 245 415 415 ASN ASN B . n 
B 2 246 SER 246 416 416 SER SER B . n 
B 2 247 LYS 247 417 417 LYS LYS B . n 
B 2 248 TYR 248 418 418 TYR TYR B . n 
B 2 249 HIS 249 419 419 HIS HIS B . n 
B 2 250 GLY 250 420 420 GLY GLY B . n 
B 2 251 VAL 251 421 421 VAL VAL B . n 
B 2 252 SER 252 422 422 SER SER B . n 
B 2 253 LEU 253 423 423 LEU LEU B . n 
B 2 254 LEU 254 424 424 LEU LEU B . n 
B 2 255 ASN 255 425 425 ASN ASN B . n 
B 2 256 PRO 256 426 426 PRO PRO B . n 
B 2 257 PRO 257 427 427 PRO PRO B . n 
B 2 258 GLU 258 428 428 GLU GLU B . n 
B 2 259 THR 259 429 429 THR THR B . n 
B 2 260 LEU 260 430 430 LEU LEU B . n 
B 2 261 ASN 261 431 431 ASN ASN B . n 
B 2 262 VAL 262 432 432 VAL VAL B . n 
B 2 263 HIS 263 433 ?   ?   ?   B . n 
B 2 264 HIS 264 434 ?   ?   ?   B . n 
B 2 265 HIS 265 435 ?   ?   ?   B . n 
B 2 266 HIS 266 436 ?   ?   ?   B . n 
B 2 267 HIS 267 437 ?   ?   ?   B . n 
B 2 268 HIS 268 438 ?   ?   ?   B . n 
C 1 1   GLY 1   -3  ?   ?   ?   C . n 
C 1 2   PRO 2   -2  ?   ?   ?   C . n 
C 1 3   GLY 3   -1  ?   ?   ?   C . n 
C 1 4   SER 4   0   0   SER SER C . n 
C 1 5   MET 5   1   1   MET MET C . n 
C 1 6   GLU 6   2   2   GLU GLU C . n 
C 1 7   ASN 7   3   3   ASN ASN C . n 
C 1 8   PHE 8   4   4   PHE PHE C . n 
C 1 9   GLN 9   5   5   GLN GLN C . n 
C 1 10  LYS 10  6   6   LYS LYS C . n 
C 1 11  VAL 11  7   7   VAL VAL C . n 
C 1 12  GLU 12  8   8   GLU GLU C . n 
C 1 13  LYS 13  9   9   LYS LYS C . n 
C 1 14  ILE 14  10  10  ILE ILE C . n 
C 1 15  GLY 15  11  11  GLY GLY C . n 
C 1 16  GLU 16  12  12  GLU GLU C . n 
C 1 17  GLY 17  13  13  GLY GLY C . n 
C 1 18  THR 18  14  14  THR THR C . n 
C 1 19  TYR 19  15  15  TYR TYR C . n 
C 1 20  GLY 20  16  16  GLY GLY C . n 
C 1 21  VAL 21  17  17  VAL VAL C . n 
C 1 22  VAL 22  18  18  VAL VAL C . n 
C 1 23  TYR 23  19  19  TYR TYR C . n 
C 1 24  LYS 24  20  20  LYS LYS C . n 
C 1 25  ALA 25  21  21  ALA ALA C . n 
C 1 26  ARG 26  22  22  ARG ARG C . n 
C 1 27  ASN 27  23  23  ASN ASN C . n 
C 1 28  LYS 28  24  24  LYS LYS C . n 
C 1 29  LEU 29  25  25  LEU LEU C . n 
C 1 30  THR 30  26  26  THR THR C . n 
C 1 31  GLY 31  27  27  GLY GLY C . n 
C 1 32  GLU 32  28  28  GLU GLU C . n 
C 1 33  VAL 33  29  29  VAL VAL C . n 
C 1 34  VAL 34  30  30  VAL VAL C . n 
C 1 35  ALA 35  31  31  ALA ALA C . n 
C 1 36  LEU 36  32  32  LEU LEU C . n 
C 1 37  LYS 37  33  33  LYS LYS C . n 
C 1 38  LYS 38  34  34  LYS LYS C . n 
C 1 39  ILE 39  35  35  ILE ILE C . n 
C 1 40  ARG 40  36  36  ARG ARG C . n 
C 1 41  LEU 41  37  37  LEU LEU C . n 
C 1 42  ASP 42  38  38  ASP ASP C . n 
C 1 43  THR 43  39  39  THR THR C . n 
C 1 44  GLU 44  40  40  GLU GLU C . n 
C 1 45  THR 45  41  41  THR THR C . n 
C 1 46  GLU 46  42  42  GLU GLU C . n 
C 1 47  GLY 47  43  43  GLY GLY C . n 
C 1 48  VAL 48  44  44  VAL VAL C . n 
C 1 49  PRO 49  45  45  PRO PRO C . n 
C 1 50  SER 50  46  46  SER SER C . n 
C 1 51  THR 51  47  47  THR THR C . n 
C 1 52  ALA 52  48  48  ALA ALA C . n 
C 1 53  ILE 53  49  49  ILE ILE C . n 
C 1 54  ARG 54  50  50  ARG ARG C . n 
C 1 55  GLU 55  51  51  GLU GLU C . n 
C 1 56  ILE 56  52  52  ILE ILE C . n 
C 1 57  SER 57  53  53  SER SER C . n 
C 1 58  LEU 58  54  54  LEU LEU C . n 
C 1 59  LEU 59  55  55  LEU LEU C . n 
C 1 60  LYS 60  56  56  LYS LYS C . n 
C 1 61  GLU 61  57  57  GLU GLU C . n 
C 1 62  LEU 62  58  58  LEU LEU C . n 
C 1 63  ASN 63  59  59  ASN ASN C . n 
C 1 64  HIS 64  60  60  HIS HIS C . n 
C 1 65  PRO 65  61  61  PRO PRO C . n 
C 1 66  ASN 66  62  62  ASN ASN C . n 
C 1 67  ILE 67  63  63  ILE ILE C . n 
C 1 68  VAL 68  64  64  VAL VAL C . n 
C 1 69  LYS 69  65  65  LYS LYS C . n 
C 1 70  LEU 70  66  66  LEU LEU C . n 
C 1 71  LEU 71  67  67  LEU LEU C . n 
C 1 72  ASP 72  68  68  ASP ASP C . n 
C 1 73  VAL 73  69  69  VAL VAL C . n 
C 1 74  ILE 74  70  70  ILE ILE C . n 
C 1 75  HIS 75  71  71  HIS HIS C . n 
C 1 76  THR 76  72  72  THR THR C . n 
C 1 77  GLU 77  73  73  GLU GLU C . n 
C 1 78  ASN 78  74  74  ASN ASN C . n 
C 1 79  LYS 79  75  75  LYS LYS C . n 
C 1 80  LEU 80  76  76  LEU LEU C . n 
C 1 81  TYR 81  77  77  TYR TYR C . n 
C 1 82  LEU 82  78  78  LEU LEU C . n 
C 1 83  VAL 83  79  79  VAL VAL C . n 
C 1 84  PHE 84  80  80  PHE PHE C . n 
C 1 85  GLU 85  81  81  GLU GLU C . n 
C 1 86  PHE 86  82  82  PHE PHE C . n 
C 1 87  LEU 87  83  83  LEU LEU C . n 
C 1 88  HIS 88  84  84  HIS HIS C . n 
C 1 89  GLN 89  85  85  GLN GLN C . n 
C 1 90  ASP 90  86  86  ASP ASP C . n 
C 1 91  LEU 91  87  87  LEU LEU C . n 
C 1 92  LYS 92  88  88  LYS LYS C . n 
C 1 93  LYS 93  89  89  LYS LYS C . n 
C 1 94  PHE 94  90  90  PHE PHE C . n 
C 1 95  MET 95  91  91  MET MET C . n 
C 1 96  ASP 96  92  92  ASP ASP C . n 
C 1 97  ALA 97  93  93  ALA ALA C . n 
C 1 98  SER 98  94  94  SER SER C . n 
C 1 99  ALA 99  95  95  ALA ALA C . n 
C 1 100 LEU 100 96  96  LEU LEU C . n 
C 1 101 THR 101 97  97  THR THR C . n 
C 1 102 GLY 102 98  98  GLY GLY C . n 
C 1 103 ILE 103 99  99  ILE ILE C . n 
C 1 104 PRO 104 100 100 PRO PRO C . n 
C 1 105 LEU 105 101 101 LEU LEU C . n 
C 1 106 PRO 106 102 102 PRO PRO C . n 
C 1 107 LEU 107 103 103 LEU LEU C . n 
C 1 108 ILE 108 104 104 ILE ILE C . n 
C 1 109 LYS 109 105 105 LYS LYS C . n 
C 1 110 SER 110 106 106 SER SER C . n 
C 1 111 TYR 111 107 107 TYR TYR C . n 
C 1 112 LEU 112 108 108 LEU LEU C . n 
C 1 113 PHE 113 109 109 PHE PHE C . n 
C 1 114 GLN 114 110 110 GLN GLN C . n 
C 1 115 LEU 115 111 111 LEU LEU C . n 
C 1 116 LEU 116 112 112 LEU LEU C . n 
C 1 117 GLN 117 113 113 GLN GLN C . n 
C 1 118 GLY 118 114 114 GLY GLY C . n 
C 1 119 LEU 119 115 115 LEU LEU C . n 
C 1 120 ALA 120 116 116 ALA ALA C . n 
C 1 121 PHE 121 117 117 PHE PHE C . n 
C 1 122 CYS 122 118 118 CYS CYS C . n 
C 1 123 HIS 123 119 119 HIS HIS C . n 
C 1 124 SER 124 120 120 SER SER C . n 
C 1 125 HIS 125 121 121 HIS HIS C . n 
C 1 126 ARG 126 122 122 ARG ARG C . n 
C 1 127 VAL 127 123 123 VAL VAL C . n 
C 1 128 LEU 128 124 124 LEU LEU C . n 
C 1 129 HIS 129 125 125 HIS HIS C . n 
C 1 130 ARG 130 126 126 ARG ARG C . n 
C 1 131 ASP 131 127 127 ASP ASP C . n 
C 1 132 LEU 132 128 128 LEU LEU C . n 
C 1 133 LYS 133 129 129 LYS LYS C . n 
C 1 134 PRO 134 130 130 PRO PRO C . n 
C 1 135 GLN 135 131 131 GLN GLN C . n 
C 1 136 ASN 136 132 132 ASN ASN C . n 
C 1 137 LEU 137 133 133 LEU LEU C . n 
C 1 138 LEU 138 134 134 LEU LEU C . n 
C 1 139 ILE 139 135 135 ILE ILE C . n 
C 1 140 ASN 140 136 136 ASN ASN C . n 
C 1 141 THR 141 137 137 THR THR C . n 
C 1 142 GLU 142 138 138 GLU GLU C . n 
C 1 143 GLY 143 139 139 GLY GLY C . n 
C 1 144 ALA 144 140 140 ALA ALA C . n 
C 1 145 ILE 145 141 141 ILE ILE C . n 
C 1 146 LYS 146 142 142 LYS LYS C . n 
C 1 147 LEU 147 143 143 LEU LEU C . n 
C 1 148 ALA 148 144 144 ALA ALA C . n 
C 1 149 ASP 149 145 145 ASP ASP C . n 
C 1 150 PHE 150 146 146 PHE PHE C . n 
C 1 151 GLY 151 147 147 GLY GLY C . n 
C 1 152 LEU 152 148 148 LEU LEU C . n 
C 1 153 ALA 153 149 149 ALA ALA C . n 
C 1 154 ARG 154 150 150 ARG ARG C . n 
C 1 155 ALA 155 151 151 ALA ALA C . n 
C 1 156 PHE 156 152 152 PHE PHE C . n 
C 1 157 GLY 157 153 153 GLY GLY C . n 
C 1 158 VAL 158 154 154 VAL VAL C . n 
C 1 159 PRO 159 155 155 PRO PRO C . n 
C 1 160 VAL 160 156 156 VAL VAL C . n 
C 1 161 ARG 161 157 157 ARG ARG C . n 
C 1 162 THR 162 158 158 THR THR C . n 
C 1 163 TYR 163 159 159 TYR TYR C . n 
C 1 164 TPO 164 160 160 TPO TPO C . n 
C 1 165 HIS 165 161 161 HIS HIS C . n 
C 1 166 GLU 166 162 162 GLU GLU C . n 
C 1 167 VAL 167 163 163 VAL VAL C . n 
C 1 168 VAL 168 164 164 VAL VAL C . n 
C 1 169 THR 169 165 165 THR THR C . n 
C 1 170 LEU 170 166 166 LEU LEU C . n 
C 1 171 TRP 171 167 167 TRP TRP C . n 
C 1 172 TYR 172 168 168 TYR TYR C . n 
C 1 173 ARG 173 169 169 ARG ARG C . n 
C 1 174 ALA 174 170 170 ALA ALA C . n 
C 1 175 PRO 175 171 171 PRO PRO C . n 
C 1 176 GLU 176 172 172 GLU GLU C . n 
C 1 177 ILE 177 173 173 ILE ILE C . n 
C 1 178 LEU 178 174 174 LEU LEU C . n 
C 1 179 LEU 179 175 175 LEU LEU C . n 
C 1 180 GLY 180 176 176 GLY GLY C . n 
C 1 181 CYS 181 177 177 CYS CYS C . n 
C 1 182 LYS 182 178 178 LYS LYS C . n 
C 1 183 TYR 183 179 179 TYR TYR C . n 
C 1 184 TYR 184 180 180 TYR TYR C . n 
C 1 185 SER 185 181 181 SER SER C . n 
C 1 186 THR 186 182 182 THR THR C . n 
C 1 187 ALA 187 183 183 ALA ALA C . n 
C 1 188 VAL 188 184 184 VAL VAL C . n 
C 1 189 ASP 189 185 185 ASP ASP C . n 
C 1 190 ILE 190 186 186 ILE ILE C . n 
C 1 191 TRP 191 187 187 TRP TRP C . n 
C 1 192 SER 192 188 188 SER SER C . n 
C 1 193 LEU 193 189 189 LEU LEU C . n 
C 1 194 GLY 194 190 190 GLY GLY C . n 
C 1 195 CYS 195 191 191 CYS CYS C . n 
C 1 196 ILE 196 192 192 ILE ILE C . n 
C 1 197 PHE 197 193 193 PHE PHE C . n 
C 1 198 ALA 198 194 194 ALA ALA C . n 
C 1 199 GLU 199 195 195 GLU GLU C . n 
C 1 200 MET 200 196 196 MET MET C . n 
C 1 201 VAL 201 197 197 VAL VAL C . n 
C 1 202 THR 202 198 198 THR THR C . n 
C 1 203 ARG 203 199 199 ARG ARG C . n 
C 1 204 ARG 204 200 200 ARG ARG C . n 
C 1 205 ALA 205 201 201 ALA ALA C . n 
C 1 206 LEU 206 202 202 LEU LEU C . n 
C 1 207 PHE 207 203 203 PHE PHE C . n 
C 1 208 PRO 208 204 204 PRO PRO C . n 
C 1 209 GLY 209 205 205 GLY GLY C . n 
C 1 210 ASP 210 206 206 ASP ASP C . n 
C 1 211 SER 211 207 207 SER SER C . n 
C 1 212 GLU 212 208 208 GLU GLU C . n 
C 1 213 ILE 213 209 209 ILE ILE C . n 
C 1 214 ASP 214 210 210 ASP ASP C . n 
C 1 215 GLN 215 211 211 GLN GLN C . n 
C 1 216 LEU 216 212 212 LEU LEU C . n 
C 1 217 PHE 217 213 213 PHE PHE C . n 
C 1 218 ARG 218 214 214 ARG ARG C . n 
C 1 219 ILE 219 215 215 ILE ILE C . n 
C 1 220 PHE 220 216 216 PHE PHE C . n 
C 1 221 ARG 221 217 217 ARG ARG C . n 
C 1 222 THR 222 218 218 THR THR C . n 
C 1 223 LEU 223 219 219 LEU LEU C . n 
C 1 224 GLY 224 220 220 GLY GLY C . n 
C 1 225 THR 225 221 221 THR THR C . n 
C 1 226 PRO 226 222 ?   ?   ?   C . n 
C 1 227 ASP 227 223 ?   ?   ?   C . n 
C 1 228 GLU 228 224 ?   ?   ?   C . n 
C 1 229 VAL 229 225 ?   ?   ?   C . n 
C 1 230 VAL 230 226 ?   ?   ?   C . n 
C 1 231 TRP 231 227 ?   ?   ?   C . n 
C 1 232 PRO 232 228 ?   ?   ?   C . n 
C 1 233 GLY 233 229 ?   ?   ?   C . n 
C 1 234 VAL 234 230 ?   ?   ?   C . n 
C 1 235 THR 235 231 ?   ?   ?   C . n 
C 1 236 SER 236 232 ?   ?   ?   C . n 
C 1 237 MET 237 233 ?   ?   ?   C . n 
C 1 238 PRO 238 234 ?   ?   ?   C . n 
C 1 239 ASP 239 235 ?   ?   ?   C . n 
C 1 240 TYR 240 236 ?   ?   ?   C . n 
C 1 241 LYS 241 237 ?   ?   ?   C . n 
C 1 242 PRO 242 238 ?   ?   ?   C . n 
C 1 243 SER 243 239 ?   ?   ?   C . n 
C 1 244 PHE 244 240 ?   ?   ?   C . n 
C 1 245 PRO 245 241 ?   ?   ?   C . n 
C 1 246 LYS 246 242 ?   ?   ?   C . n 
C 1 247 TRP 247 243 ?   ?   ?   C . n 
C 1 248 ALA 248 244 ?   ?   ?   C . n 
C 1 249 ARG 249 245 ?   ?   ?   C . n 
C 1 250 GLN 250 246 ?   ?   ?   C . n 
C 1 251 ASP 251 247 ?   ?   ?   C . n 
C 1 252 PHE 252 248 ?   ?   ?   C . n 
C 1 253 SER 253 249 249 SER SER C . n 
C 1 254 LYS 254 250 250 LYS LYS C . n 
C 1 255 VAL 255 251 251 VAL VAL C . n 
C 1 256 VAL 256 252 252 VAL VAL C . n 
C 1 257 PRO 257 253 253 PRO PRO C . n 
C 1 258 PRO 258 254 254 PRO PRO C . n 
C 1 259 LEU 259 255 255 LEU LEU C . n 
C 1 260 ASP 260 256 256 ASP ASP C . n 
C 1 261 GLU 261 257 257 GLU GLU C . n 
C 1 262 ASP 262 258 258 ASP ASP C . n 
C 1 263 GLY 263 259 259 GLY GLY C . n 
C 1 264 ARG 264 260 260 ARG ARG C . n 
C 1 265 SER 265 261 261 SER SER C . n 
C 1 266 LEU 266 262 262 LEU LEU C . n 
C 1 267 LEU 267 263 263 LEU LEU C . n 
C 1 268 SER 268 264 264 SER SER C . n 
C 1 269 GLN 269 265 265 GLN GLN C . n 
C 1 270 MET 270 266 266 MET MET C . n 
C 1 271 LEU 271 267 267 LEU LEU C . n 
C 1 272 HIS 272 268 268 HIS HIS C . n 
C 1 273 TYR 273 269 269 TYR TYR C . n 
C 1 274 ASP 274 270 270 ASP ASP C . n 
C 1 275 PRO 275 271 271 PRO PRO C . n 
C 1 276 ASN 276 272 272 ASN ASN C . n 
C 1 277 LYS 277 273 273 LYS LYS C . n 
C 1 278 ARG 278 274 274 ARG ARG C . n 
C 1 279 ILE 279 275 275 ILE ILE C . n 
C 1 280 SER 280 276 276 SER SER C . n 
C 1 281 ALA 281 277 277 ALA ALA C . n 
C 1 282 LYS 282 278 278 LYS LYS C . n 
C 1 283 ALA 283 279 279 ALA ALA C . n 
C 1 284 ALA 284 280 280 ALA ALA C . n 
C 1 285 LEU 285 281 281 LEU LEU C . n 
C 1 286 ALA 286 282 282 ALA ALA C . n 
C 1 287 HIS 287 283 283 HIS HIS C . n 
C 1 288 PRO 288 284 284 PRO PRO C . n 
C 1 289 PHE 289 285 285 PHE PHE C . n 
C 1 290 PHE 290 286 286 PHE PHE C . n 
C 1 291 GLN 291 287 287 GLN GLN C . n 
C 1 292 ASP 292 288 288 ASP ASP C . n 
C 1 293 VAL 293 289 289 VAL VAL C . n 
C 1 294 THR 294 290 290 THR THR C . n 
C 1 295 LYS 295 291 291 LYS LYS C . n 
C 1 296 PRO 296 292 292 PRO PRO C . n 
C 1 297 VAL 297 293 293 VAL VAL C . n 
C 1 298 PRO 298 294 294 PRO PRO C . n 
C 1 299 HIS 299 295 295 HIS HIS C . n 
C 1 300 LEU 300 296 296 LEU LEU C . n 
C 1 301 ARG 301 297 ?   ?   ?   C . n 
C 1 302 LEU 302 298 ?   ?   ?   C . n 
D 2 1   GLY 1   171 171 GLY GLY D . n 
D 2 2   VAL 2   172 172 VAL VAL D . n 
D 2 3   ASN 3   173 173 ASN ASN D . n 
D 2 4   GLU 4   174 174 GLU GLU D . n 
D 2 5   VAL 5   175 175 VAL VAL D . n 
D 2 6   PRO 6   176 176 PRO PRO D . n 
D 2 7   ASP 7   177 177 ASP ASP D . n 
D 2 8   TYR 8   178 178 TYR TYR D . n 
D 2 9   HIS 9   179 179 HIS HIS D . n 
D 2 10  GLU 10  180 180 GLU GLU D . n 
D 2 11  ASP 11  181 181 ASP ASP D . n 
D 2 12  ILE 12  182 182 ILE ILE D . n 
D 2 13  HIS 13  183 183 HIS HIS D . n 
D 2 14  THR 14  184 184 THR THR D . n 
D 2 15  TYR 15  185 185 TYR TYR D . n 
D 2 16  LEU 16  186 186 LEU LEU D . n 
D 2 17  ARG 17  187 187 ARG ARG D . n 
D 2 18  GLU 18  188 188 GLU GLU D . n 
D 2 19  MET 19  189 189 MET MET D . n 
D 2 20  GLU 20  190 190 GLU GLU D . n 
D 2 21  VAL 21  191 191 VAL VAL D . n 
D 2 22  LYS 22  192 192 LYS LYS D . n 
D 2 23  CYS 23  193 193 CYS CYS D . n 
D 2 24  LYS 24  194 194 LYS LYS D . n 
D 2 25  PRO 25  195 195 PRO PRO D . n 
D 2 26  LYS 26  196 196 LYS LYS D . n 
D 2 27  VAL 27  197 197 VAL VAL D . n 
D 2 28  GLY 28  198 198 GLY GLY D . n 
D 2 29  TYR 29  199 199 TYR TYR D . n 
D 2 30  MET 30  200 200 MET MET D . n 
D 2 31  LYS 31  201 201 LYS LYS D . n 
D 2 32  LYS 32  202 202 LYS LYS D . n 
D 2 33  GLN 33  203 203 GLN GLN D . n 
D 2 34  PRO 34  204 204 PRO PRO D . n 
D 2 35  ASP 35  205 205 ASP ASP D . n 
D 2 36  ILE 36  206 206 ILE ILE D . n 
D 2 37  THR 37  207 207 THR THR D . n 
D 2 38  ASN 38  208 208 ASN ASN D . n 
D 2 39  SER 39  209 209 SER SER D . n 
D 2 40  MET 40  210 210 MET MET D . n 
D 2 41  ARG 41  211 211 ARG ARG D . n 
D 2 42  ALA 42  212 212 ALA ALA D . n 
D 2 43  ILE 43  213 213 ILE ILE D . n 
D 2 44  LEU 44  214 214 LEU LEU D . n 
D 2 45  VAL 45  215 215 VAL VAL D . n 
D 2 46  ASP 46  216 216 ASP ASP D . n 
D 2 47  TRP 47  217 217 TRP TRP D . n 
D 2 48  LEU 48  218 218 LEU LEU D . n 
D 2 49  VAL 49  219 219 VAL VAL D . n 
D 2 50  GLU 50  220 220 GLU GLU D . n 
D 2 51  VAL 51  221 221 VAL VAL D . n 
D 2 52  GLY 52  222 222 GLY GLY D . n 
D 2 53  GLU 53  223 223 GLU GLU D . n 
D 2 54  GLU 54  224 224 GLU GLU D . n 
D 2 55  TYR 55  225 225 TYR TYR D . n 
D 2 56  LYS 56  226 226 LYS LYS D . n 
D 2 57  LEU 57  227 227 LEU LEU D . n 
D 2 58  GLN 58  228 228 GLN GLN D . n 
D 2 59  ASN 59  229 229 ASN ASN D . n 
D 2 60  GLU 60  230 230 GLU GLU D . n 
D 2 61  THR 61  231 231 THR THR D . n 
D 2 62  LEU 62  232 232 LEU LEU D . n 
D 2 63  HIS 63  233 233 HIS HIS D . n 
D 2 64  LEU 64  234 234 LEU LEU D . n 
D 2 65  ALA 65  235 235 ALA ALA D . n 
D 2 66  VAL 66  236 236 VAL VAL D . n 
D 2 67  ASN 67  237 237 ASN ASN D . n 
D 2 68  TYR 68  238 238 TYR TYR D . n 
D 2 69  ILE 69  239 239 ILE ILE D . n 
D 2 70  ASP 70  240 240 ASP ASP D . n 
D 2 71  ARG 71  241 241 ARG ARG D . n 
D 2 72  PHE 72  242 242 PHE PHE D . n 
D 2 73  LEU 73  243 243 LEU LEU D . n 
D 2 74  SER 74  244 244 SER SER D . n 
D 2 75  SER 75  245 245 SER SER D . n 
D 2 76  MET 76  246 246 MET MET D . n 
D 2 77  SER 77  247 247 SER SER D . n 
D 2 78  VAL 78  248 248 VAL VAL D . n 
D 2 79  LEU 79  249 249 LEU LEU D . n 
D 2 80  ARG 80  250 250 ARG ARG D . n 
D 2 81  GLY 81  251 251 GLY GLY D . n 
D 2 82  LYS 82  252 252 LYS LYS D . n 
D 2 83  LEU 83  253 253 LEU LEU D . n 
D 2 84  GLN 84  254 254 GLN GLN D . n 
D 2 85  LEU 85  255 255 LEU LEU D . n 
D 2 86  VAL 86  256 256 VAL VAL D . n 
D 2 87  GLY 87  257 257 GLY GLY D . n 
D 2 88  THR 88  258 258 THR THR D . n 
D 2 89  ALA 89  259 259 ALA ALA D . n 
D 2 90  ALA 90  260 260 ALA ALA D . n 
D 2 91  MET 91  261 261 MET MET D . n 
D 2 92  LEU 92  262 262 LEU LEU D . n 
D 2 93  LEU 93  263 263 LEU LEU D . n 
D 2 94  ALA 94  264 264 ALA ALA D . n 
D 2 95  SER 95  265 265 SER SER D . n 
D 2 96  LYS 96  266 266 LYS LYS D . n 
D 2 97  PHE 97  267 267 PHE PHE D . n 
D 2 98  GLU 98  268 268 GLU GLU D . n 
D 2 99  GLU 99  269 269 GLU GLU D . n 
D 2 100 ILE 100 270 270 ILE ILE D . n 
D 2 101 TYR 101 271 271 TYR TYR D . n 
D 2 102 PRO 102 272 272 PRO PRO D . n 
D 2 103 PRO 103 273 273 PRO PRO D . n 
D 2 104 GLU 104 274 274 GLU GLU D . n 
D 2 105 VAL 105 275 275 VAL VAL D . n 
D 2 106 ALA 106 276 276 ALA ALA D . n 
D 2 107 GLU 107 277 277 GLU GLU D . n 
D 2 108 PHE 108 278 278 PHE PHE D . n 
D 2 109 VAL 109 279 279 VAL VAL D . n 
D 2 110 TYR 110 280 280 TYR TYR D . n 
D 2 111 ILE 111 281 281 ILE ILE D . n 
D 2 112 THR 112 282 282 THR THR D . n 
D 2 113 ASP 113 283 283 ASP ASP D . n 
D 2 114 ASP 114 284 284 ASP ASP D . n 
D 2 115 THR 115 285 285 THR THR D . n 
D 2 116 TYR 116 286 286 TYR TYR D . n 
D 2 117 THR 117 287 287 THR THR D . n 
D 2 118 LYS 118 288 288 LYS LYS D . n 
D 2 119 LYS 119 289 289 LYS LYS D . n 
D 2 120 GLN 120 290 290 GLN GLN D . n 
D 2 121 VAL 121 291 291 VAL VAL D . n 
D 2 122 LEU 122 292 292 LEU LEU D . n 
D 2 123 ARG 123 293 293 ARG ARG D . n 
D 2 124 MET 124 294 294 MET MET D . n 
D 2 125 GLU 125 295 295 GLU GLU D . n 
D 2 126 HIS 126 296 296 HIS HIS D . n 
D 2 127 LEU 127 297 297 LEU LEU D . n 
D 2 128 VAL 128 298 298 VAL VAL D . n 
D 2 129 LEU 129 299 299 LEU LEU D . n 
D 2 130 LYS 130 300 300 LYS LYS D . n 
D 2 131 VAL 131 301 301 VAL VAL D . n 
D 2 132 LEU 132 302 302 LEU LEU D . n 
D 2 133 ALA 133 303 303 ALA ALA D . n 
D 2 134 PHE 134 304 304 PHE PHE D . n 
D 2 135 ASP 135 305 305 ASP ASP D . n 
D 2 136 LEU 136 306 306 LEU LEU D . n 
D 2 137 ALA 137 307 307 ALA ALA D . n 
D 2 138 ALA 138 308 308 ALA ALA D . n 
D 2 139 PRO 139 309 309 PRO PRO D . n 
D 2 140 THR 140 310 310 THR THR D . n 
D 2 141 ILE 141 311 311 ILE ILE D . n 
D 2 142 ASN 142 312 312 ASN ASN D . n 
D 2 143 GLN 143 313 313 GLN GLN D . n 
D 2 144 PHE 144 314 314 PHE PHE D . n 
D 2 145 LEU 145 315 315 LEU LEU D . n 
D 2 146 THR 146 316 316 THR THR D . n 
D 2 147 GLN 147 317 317 GLN GLN D . n 
D 2 148 TYR 148 318 318 TYR TYR D . n 
D 2 149 PHE 149 319 319 PHE PHE D . n 
D 2 150 LEU 150 320 320 LEU LEU D . n 
D 2 151 HIS 151 321 321 HIS HIS D . n 
D 2 152 GLN 152 322 322 GLN GLN D . n 
D 2 153 GLN 153 323 323 GLN GLN D . n 
D 2 154 PRO 154 324 324 PRO PRO D . n 
D 2 155 ALA 155 325 325 ALA ALA D . n 
D 2 156 ASN 156 326 326 ASN ASN D . n 
D 2 157 CYS 157 327 327 CYS CYS D . n 
D 2 158 LYS 158 328 328 LYS LYS D . n 
D 2 159 VAL 159 329 329 VAL VAL D . n 
D 2 160 GLU 160 330 330 GLU GLU D . n 
D 2 161 SER 161 331 331 SER SER D . n 
D 2 162 LEU 162 332 332 LEU LEU D . n 
D 2 163 ALA 163 333 333 ALA ALA D . n 
D 2 164 MET 164 334 334 MET MET D . n 
D 2 165 PHE 165 335 335 PHE PHE D . n 
D 2 166 LEU 166 336 336 LEU LEU D . n 
D 2 167 GLY 167 337 337 GLY GLY D . n 
D 2 168 GLU 168 338 338 GLU GLU D . n 
D 2 169 LEU 169 339 339 LEU LEU D . n 
D 2 170 SER 170 340 340 SER SER D . n 
D 2 171 LEU 171 341 341 LEU LEU D . n 
D 2 172 ILE 172 342 342 ILE ILE D . n 
D 2 173 ASP 173 343 343 ASP ASP D . n 
D 2 174 ALA 174 344 344 ALA ALA D . n 
D 2 175 ASP 175 345 345 ASP ASP D . n 
D 2 176 PRO 176 346 346 PRO PRO D . n 
D 2 177 TYR 177 347 347 TYR TYR D . n 
D 2 178 LEU 178 348 348 LEU LEU D . n 
D 2 179 LYS 179 349 349 LYS LYS D . n 
D 2 180 TYR 180 350 350 TYR TYR D . n 
D 2 181 LEU 181 351 351 LEU LEU D . n 
D 2 182 PRO 182 352 352 PRO PRO D . n 
D 2 183 SER 183 353 353 SER SER D . n 
D 2 184 VAL 184 354 354 VAL VAL D . n 
D 2 185 ILE 185 355 355 ILE ILE D . n 
D 2 186 ALA 186 356 356 ALA ALA D . n 
D 2 187 ALA 187 357 357 ALA ALA D . n 
D 2 188 ALA 188 358 358 ALA ALA D . n 
D 2 189 ALA 189 359 359 ALA ALA D . n 
D 2 190 PHE 190 360 360 PHE PHE D . n 
D 2 191 HIS 191 361 361 HIS HIS D . n 
D 2 192 LEU 192 362 362 LEU LEU D . n 
D 2 193 ALA 193 363 363 ALA ALA D . n 
D 2 194 LEU 194 364 364 LEU LEU D . n 
D 2 195 TYR 195 365 365 TYR TYR D . n 
D 2 196 THR 196 366 366 THR THR D . n 
D 2 197 VAL 197 367 367 VAL VAL D . n 
D 2 198 THR 198 368 368 THR THR D . n 
D 2 199 GLY 199 369 369 GLY GLY D . n 
D 2 200 GLN 200 370 370 GLN GLN D . n 
D 2 201 SER 201 371 371 SER SER D . n 
D 2 202 TRP 202 372 372 TRP TRP D . n 
D 2 203 PRO 203 373 373 PRO PRO D . n 
D 2 204 GLU 204 374 374 GLU GLU D . n 
D 2 205 SER 205 375 375 SER SER D . n 
D 2 206 LEU 206 376 376 LEU LEU D . n 
D 2 207 VAL 207 377 377 VAL VAL D . n 
D 2 208 GLN 208 378 378 GLN GLN D . n 
D 2 209 LYS 209 379 379 LYS LYS D . n 
D 2 210 THR 210 380 380 THR THR D . n 
D 2 211 GLY 211 381 381 GLY GLY D . n 
D 2 212 TYR 212 382 382 TYR TYR D . n 
D 2 213 THR 213 383 383 THR THR D . n 
D 2 214 LEU 214 384 384 LEU LEU D . n 
D 2 215 GLU 215 385 385 GLU GLU D . n 
D 2 216 THR 216 386 386 THR THR D . n 
D 2 217 LEU 217 387 387 LEU LEU D . n 
D 2 218 LYS 218 388 388 LYS LYS D . n 
D 2 219 PRO 219 389 389 PRO PRO D . n 
D 2 220 CYS 220 390 390 CYS CYS D . n 
D 2 221 LEU 221 391 391 LEU LEU D . n 
D 2 222 LEU 222 392 392 LEU LEU D . n 
D 2 223 ASP 223 393 393 ASP ASP D . n 
D 2 224 LEU 224 394 394 LEU LEU D . n 
D 2 225 HIS 225 395 395 HIS HIS D . n 
D 2 226 GLN 226 396 396 GLN GLN D . n 
D 2 227 THR 227 397 397 THR THR D . n 
D 2 228 TYR 228 398 398 TYR TYR D . n 
D 2 229 LEU 229 399 399 LEU LEU D . n 
D 2 230 ARG 230 400 400 ARG ARG D . n 
D 2 231 ALA 231 401 401 ALA ALA D . n 
D 2 232 PRO 232 402 402 PRO PRO D . n 
D 2 233 GLN 233 403 403 GLN GLN D . n 
D 2 234 HIS 234 404 404 HIS HIS D . n 
D 2 235 ALA 235 405 405 ALA ALA D . n 
D 2 236 GLN 236 406 406 GLN GLN D . n 
D 2 237 GLN 237 407 407 GLN GLN D . n 
D 2 238 SER 238 408 408 SER SER D . n 
D 2 239 ILE 239 409 409 ILE ILE D . n 
D 2 240 ARG 240 410 410 ARG ARG D . n 
D 2 241 GLU 241 411 411 GLU GLU D . n 
D 2 242 LYS 242 412 412 LYS LYS D . n 
D 2 243 TYR 243 413 413 TYR TYR D . n 
D 2 244 LYS 244 414 414 LYS LYS D . n 
D 2 245 ASN 245 415 415 ASN ASN D . n 
D 2 246 SER 246 416 416 SER SER D . n 
D 2 247 LYS 247 417 417 LYS LYS D . n 
D 2 248 TYR 248 418 418 TYR TYR D . n 
D 2 249 HIS 249 419 419 HIS HIS D . n 
D 2 250 GLY 250 420 420 GLY GLY D . n 
D 2 251 VAL 251 421 421 VAL VAL D . n 
D 2 252 SER 252 422 422 SER SER D . n 
D 2 253 LEU 253 423 423 LEU LEU D . n 
D 2 254 LEU 254 424 424 LEU LEU D . n 
D 2 255 ASN 255 425 425 ASN ASN D . n 
D 2 256 PRO 256 426 426 PRO PRO D . n 
D 2 257 PRO 257 427 427 PRO PRO D . n 
D 2 258 GLU 258 428 428 GLU GLU D . n 
D 2 259 THR 259 429 429 THR THR D . n 
D 2 260 LEU 260 430 430 LEU LEU D . n 
D 2 261 ASN 261 431 431 ASN ASN D . n 
D 2 262 VAL 262 432 432 VAL VAL D . n 
D 2 263 HIS 263 433 ?   ?   ?   D . n 
D 2 264 HIS 264 434 ?   ?   ?   D . n 
D 2 265 HIS 265 435 ?   ?   ?   D . n 
D 2 266 HIS 266 436 ?   ?   ?   D . n 
D 2 267 HIS 267 437 ?   ?   ?   D . n 
D 2 268 HIS 268 438 ?   ?   ?   D . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        HHT 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   HHT 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 HHT 1   601 601 HHT DRG A . 
F 3 HHT 1   602 603 HHT DRG A . 
G 3 HHT 1   603 604 HHT DRG A . 
H 3 HHT 1   604 610 HHT DRG A . 
I 3 HHT 1   501 606 HHT DRG B . 
J 3 HHT 1   502 609 HHT DRG B . 
K 3 HHT 1   501 501 HHT DRG C . 
L 3 HHT 1   502 601 HHT DRG C . 
M 3 HHT 1   503 602 HHT DRG C . 
N 3 HHT 1   501 607 HHT DRG D . 
O 4 HOH 1   701 408 HOH HOH A . 
O 4 HOH 2   702 412 HOH HOH A . 
O 4 HOH 3   703 420 HOH HOH A . 
O 4 HOH 4   704 404 HOH HOH A . 
O 4 HOH 5   705 444 HOH HOH A . 
O 4 HOH 6   706 436 HOH HOH A . 
O 4 HOH 7   707 182 HOH HOH A . 
O 4 HOH 8   708 417 HOH HOH A . 
O 4 HOH 9   709 421 HOH HOH A . 
O 4 HOH 10  710 410 HOH HOH A . 
O 4 HOH 11  711 419 HOH HOH A . 
O 4 HOH 12  712 31  HOH HOH A . 
O 4 HOH 13  713 487 HOH HOH A . 
O 4 HOH 14  714 423 HOH HOH A . 
O 4 HOH 15  715 425 HOH HOH A . 
O 4 HOH 16  716 525 HOH HOH A . 
O 4 HOH 17  717 594 HOH HOH A . 
O 4 HOH 18  718 46  HOH HOH A . 
O 4 HOH 19  719 450 HOH HOH A . 
O 4 HOH 20  720 454 HOH HOH A . 
O 4 HOH 21  721 480 HOH HOH A . 
O 4 HOH 22  722 427 HOH HOH A . 
O 4 HOH 23  723 458 HOH HOH A . 
O 4 HOH 24  724 33  HOH HOH A . 
O 4 HOH 25  725 463 HOH HOH A . 
O 4 HOH 26  726 67  HOH HOH A . 
O 4 HOH 27  727 38  HOH HOH A . 
O 4 HOH 28  728 451 HOH HOH A . 
O 4 HOH 29  729 429 HOH HOH A . 
O 4 HOH 30  730 520 HOH HOH A . 
O 4 HOH 31  731 465 HOH HOH A . 
O 4 HOH 32  732 58  HOH HOH A . 
O 4 HOH 33  733 525 HOH HOH A . 
O 4 HOH 34  734 407 HOH HOH A . 
O 4 HOH 35  735 981 HOH HOH A . 
O 4 HOH 36  736 461 HOH HOH A . 
O 4 HOH 37  737 434 HOH HOH A . 
O 4 HOH 38  738 470 HOH HOH A . 
O 4 HOH 39  739 984 HOH HOH A . 
O 4 HOH 40  740 6   HOH HOH A . 
O 4 HOH 41  741 448 HOH HOH A . 
O 4 HOH 42  742 428 HOH HOH A . 
O 4 HOH 43  743 490 HOH HOH A . 
O 4 HOH 44  744 468 HOH HOH A . 
O 4 HOH 45  745 462 HOH HOH A . 
O 4 HOH 46  746 533 HOH HOH A . 
O 4 HOH 47  747 478 HOH HOH A . 
O 4 HOH 48  748 517 HOH HOH A . 
O 4 HOH 49  749 655 HOH HOH A . 
O 4 HOH 50  750 457 HOH HOH A . 
O 4 HOH 51  751 504 HOH HOH A . 
O 4 HOH 52  752 455 HOH HOH A . 
O 4 HOH 53  753 985 HOH HOH A . 
O 4 HOH 54  754 442 HOH HOH A . 
O 4 HOH 55  755 14  HOH HOH A . 
O 4 HOH 56  756 560 HOH HOH A . 
O 4 HOH 57  757 477 HOH HOH A . 
O 4 HOH 58  758 411 HOH HOH A . 
O 4 HOH 59  759 271 HOH HOH A . 
O 4 HOH 60  760 511 HOH HOH A . 
O 4 HOH 61  761 467 HOH HOH A . 
O 4 HOH 62  762 476 HOH HOH A . 
O 4 HOH 63  763 484 HOH HOH A . 
O 4 HOH 64  764 566 HOH HOH A . 
O 4 HOH 65  765 435 HOH HOH A . 
O 4 HOH 66  766 522 HOH HOH A . 
O 4 HOH 67  767 443 HOH HOH A . 
O 4 HOH 68  768 438 HOH HOH A . 
O 4 HOH 69  769 512 HOH HOH A . 
O 4 HOH 70  770 292 HOH HOH A . 
O 4 HOH 71  771 148 HOH HOH A . 
O 4 HOH 72  772 980 HOH HOH A . 
O 4 HOH 73  773 486 HOH HOH A . 
O 4 HOH 74  774 518 HOH HOH A . 
O 4 HOH 75  775 79  HOH HOH A . 
O 4 HOH 76  776 548 HOH HOH A . 
O 4 HOH 77  777 406 HOH HOH A . 
O 4 HOH 78  778 515 HOH HOH A . 
O 4 HOH 79  779 513 HOH HOH A . 
O 4 HOH 80  780 545 HOH HOH A . 
O 4 HOH 81  781 549 HOH HOH A . 
O 4 HOH 82  782 499 HOH HOH A . 
O 4 HOH 83  783 44  HOH HOH A . 
O 4 HOH 84  784 506 HOH HOH A . 
O 4 HOH 85  785 514 HOH HOH A . 
O 4 HOH 86  786 510 HOH HOH A . 
O 4 HOH 87  787 447 HOH HOH A . 
O 4 HOH 88  788 503 HOH HOH A . 
O 4 HOH 89  789 481 HOH HOH A . 
O 4 HOH 90  790 108 HOH HOH A . 
O 4 HOH 91  791 43  HOH HOH A . 
O 4 HOH 92  792 12  HOH HOH A . 
O 4 HOH 93  793 532 HOH HOH A . 
O 4 HOH 94  794 527 HOH HOH A . 
O 4 HOH 95  795 569 HOH HOH A . 
O 4 HOH 96  796 556 HOH HOH A . 
O 4 HOH 97  797 473 HOH HOH A . 
O 4 HOH 98  798 544 HOH HOH A . 
O 4 HOH 99  799 541 HOH HOH A . 
O 4 HOH 100 800 34  HOH HOH A . 
O 4 HOH 101 801 59  HOH HOH A . 
O 4 HOH 102 802 543 HOH HOH A . 
O 4 HOH 103 803 501 HOH HOH A . 
O 4 HOH 104 804 530 HOH HOH A . 
O 4 HOH 105 805 571 HOH HOH A . 
O 4 HOH 106 806 552 HOH HOH A . 
O 4 HOH 107 807 49  HOH HOH A . 
O 4 HOH 108 808 523 HOH HOH A . 
O 4 HOH 109 809 558 HOH HOH A . 
O 4 HOH 110 810 526 HOH HOH A . 
O 4 HOH 111 811 577 HOH HOH A . 
O 4 HOH 112 812 982 HOH HOH A . 
O 4 HOH 113 813 466 HOH HOH A . 
O 4 HOH 114 814 508 HOH HOH A . 
O 4 HOH 115 815 983 HOH HOH A . 
O 4 HOH 116 816 29  HOH HOH A . 
O 4 HOH 117 817 573 HOH HOH A . 
O 4 HOH 118 818 989 HOH HOH A . 
O 4 HOH 119 819 81  HOH HOH A . 
O 4 HOH 120 820 559 HOH HOH A . 
O 4 HOH 121 821 565 HOH HOH A . 
O 4 HOH 122 822 568 HOH HOH A . 
O 4 HOH 123 823 987 HOH HOH A . 
O 4 HOH 124 824 546 HOH HOH A . 
O 4 HOH 125 825 579 HOH HOH A . 
O 4 HOH 126 826 578 HOH HOH A . 
O 4 HOH 127 827 574 HOH HOH A . 
O 4 HOH 128 828 582 HOH HOH A . 
O 4 HOH 129 829 591 HOH HOH A . 
O 4 HOH 130 830 557 HOH HOH A . 
O 4 HOH 131 831 587 HOH HOH A . 
O 4 HOH 132 832 583 HOH HOH A . 
O 4 HOH 133 833 970 HOH HOH A . 
O 4 HOH 134 834 586 HOH HOH A . 
O 4 HOH 135 835 858 HOH HOH A . 
P 4 HOH 1   601 547 HOH HOH B . 
P 4 HOH 2   602 529 HOH HOH B . 
P 4 HOH 3   603 502 HOH HOH B . 
P 4 HOH 4   604 535 HOH HOH B . 
P 4 HOH 5   605 537 HOH HOH B . 
P 4 HOH 6   606 513 HOH HOH B . 
P 4 HOH 7   607 530 HOH HOH B . 
P 4 HOH 8   608 549 HOH HOH B . 
P 4 HOH 9   609 617 HOH HOH B . 
P 4 HOH 10  610 459 HOH HOH B . 
P 4 HOH 11  611 570 HOH HOH B . 
P 4 HOH 12  612 506 HOH HOH B . 
P 4 HOH 13  613 510 HOH HOH B . 
P 4 HOH 14  614 507 HOH HOH B . 
P 4 HOH 15  615 508 HOH HOH B . 
P 4 HOH 16  616 522 HOH HOH B . 
P 4 HOH 17  617 586 HOH HOH B . 
P 4 HOH 18  618 551 HOH HOH B . 
P 4 HOH 19  619 527 HOH HOH B . 
P 4 HOH 20  620 591 HOH HOH B . 
P 4 HOH 21  621 568 HOH HOH B . 
P 4 HOH 22  622 505 HOH HOH B . 
P 4 HOH 23  623 531 HOH HOH B . 
P 4 HOH 24  624 532 HOH HOH B . 
P 4 HOH 25  625 659 HOH HOH B . 
P 4 HOH 26  626 28  HOH HOH B . 
P 4 HOH 27  627 76  HOH HOH B . 
P 4 HOH 28  628 564 HOH HOH B . 
P 4 HOH 29  629 595 HOH HOH B . 
P 4 HOH 30  630 523 HOH HOH B . 
P 4 HOH 31  631 524 HOH HOH B . 
P 4 HOH 32  632 555 HOH HOH B . 
P 4 HOH 33  633 622 HOH HOH B . 
P 4 HOH 34  634 544 HOH HOH B . 
P 4 HOH 35  635 614 HOH HOH B . 
P 4 HOH 36  636 558 HOH HOH B . 
P 4 HOH 37  637 583 HOH HOH B . 
P 4 HOH 38  638 534 HOH HOH B . 
P 4 HOH 39  639 572 HOH HOH B . 
P 4 HOH 40  640 68  HOH HOH B . 
P 4 HOH 41  641 70  HOH HOH B . 
P 4 HOH 42  642 556 HOH HOH B . 
P 4 HOH 43  643 512 HOH HOH B . 
P 4 HOH 44  644 589 HOH HOH B . 
P 4 HOH 45  645 560 HOH HOH B . 
P 4 HOH 46  646 557 HOH HOH B . 
P 4 HOH 47  647 579 HOH HOH B . 
P 4 HOH 48  648 545 HOH HOH B . 
P 4 HOH 49  649 628 HOH HOH B . 
P 4 HOH 50  650 593 HOH HOH B . 
P 4 HOH 51  651 615 HOH HOH B . 
P 4 HOH 52  652 552 HOH HOH B . 
P 4 HOH 53  653 582 HOH HOH B . 
P 4 HOH 54  654 581 HOH HOH B . 
P 4 HOH 55  655 623 HOH HOH B . 
P 4 HOH 56  656 540 HOH HOH B . 
P 4 HOH 57  657 526 HOH HOH B . 
P 4 HOH 58  658 588 HOH HOH B . 
P 4 HOH 59  659 594 HOH HOH B . 
P 4 HOH 60  660 585 HOH HOH B . 
P 4 HOH 61  661 603 HOH HOH B . 
P 4 HOH 62  662 609 HOH HOH B . 
P 4 HOH 63  663 524 HOH HOH B . 
P 4 HOH 64  664 605 HOH HOH B . 
P 4 HOH 65  665 642 HOH HOH B . 
P 4 HOH 66  666 607 HOH HOH B . 
P 4 HOH 67  667 550 HOH HOH B . 
P 4 HOH 68  668 177 HOH HOH B . 
P 4 HOH 69  669 584 HOH HOH B . 
P 4 HOH 70  670 624 HOH HOH B . 
P 4 HOH 71  671 127 HOH HOH B . 
P 4 HOH 72  672 587 HOH HOH B . 
P 4 HOH 73  673 629 HOH HOH B . 
P 4 HOH 74  674 627 HOH HOH B . 
P 4 HOH 75  675 643 HOH HOH B . 
P 4 HOH 76  676 61  HOH HOH B . 
P 4 HOH 77  677 30  HOH HOH B . 
P 4 HOH 78  678 566 HOH HOH B . 
P 4 HOH 79  679 630 HOH HOH B . 
P 4 HOH 80  680 632 HOH HOH B . 
P 4 HOH 81  681 561 HOH HOH B . 
P 4 HOH 82  682 657 HOH HOH B . 
P 4 HOH 83  683 592 HOH HOH B . 
P 4 HOH 84  684 650 HOH HOH B . 
P 4 HOH 85  685 520 HOH HOH B . 
P 4 HOH 86  686 612 HOH HOH B . 
P 4 HOH 87  687 124 HOH HOH B . 
P 4 HOH 88  688 637 HOH HOH B . 
P 4 HOH 89  689 152 HOH HOH B . 
P 4 HOH 90  690 631 HOH HOH B . 
P 4 HOH 91  691 538 HOH HOH B . 
P 4 HOH 92  692 598 HOH HOH B . 
P 4 HOH 93  693 648 HOH HOH B . 
P 4 HOH 94  694 639 HOH HOH B . 
P 4 HOH 95  695 519 HOH HOH B . 
P 4 HOH 96  696 16  HOH HOH B . 
P 4 HOH 97  697 619 HOH HOH B . 
P 4 HOH 98  698 122 HOH HOH B . 
P 4 HOH 99  699 625 HOH HOH B . 
P 4 HOH 100 700 36  HOH HOH B . 
P 4 HOH 101 701 137 HOH HOH B . 
P 4 HOH 102 702 640 HOH HOH B . 
P 4 HOH 103 703 641 HOH HOH B . 
P 4 HOH 104 704 39  HOH HOH B . 
P 4 HOH 105 705 620 HOH HOH B . 
P 4 HOH 106 706 40  HOH HOH B . 
P 4 HOH 107 707 638 HOH HOH B . 
P 4 HOH 108 708 574 HOH HOH B . 
P 4 HOH 109 709 635 HOH HOH B . 
P 4 HOH 110 710 239 HOH HOH B . 
P 4 HOH 111 711 652 HOH HOH B . 
P 4 HOH 112 712 651 HOH HOH B . 
P 4 HOH 113 713 669 HOH HOH B . 
P 4 HOH 114 714 668 HOH HOH B . 
P 4 HOH 115 715 647 HOH HOH B . 
P 4 HOH 116 716 676 HOH HOH B . 
P 4 HOH 117 717 678 HOH HOH B . 
P 4 HOH 118 718 680 HOH HOH B . 
P 4 HOH 119 719 679 HOH HOH B . 
P 4 HOH 120 720 681 HOH HOH B . 
Q 4 HOH 1   601 458 HOH HOH C . 
Q 4 HOH 2   602 25  HOH HOH C . 
Q 4 HOH 3   603 979 HOH HOH C . 
Q 4 HOH 4   604 410 HOH HOH C . 
Q 4 HOH 5   605 414 HOH HOH C . 
Q 4 HOH 6   606 422 HOH HOH C . 
Q 4 HOH 7   607 417 HOH HOH C . 
Q 4 HOH 8   608 407 HOH HOH C . 
Q 4 HOH 9   609 268 HOH HOH C . 
Q 4 HOH 10  610 420 HOH HOH C . 
Q 4 HOH 11  611 155 HOH HOH C . 
Q 4 HOH 12  612 401 HOH HOH C . 
Q 4 HOH 13  613 91  HOH HOH C . 
Q 4 HOH 14  614 406 HOH HOH C . 
Q 4 HOH 15  615 73  HOH HOH C . 
Q 4 HOH 16  616 41  HOH HOH C . 
Q 4 HOH 17  617 978 HOH HOH C . 
Q 4 HOH 18  618 55  HOH HOH C . 
Q 4 HOH 19  619 438 HOH HOH C . 
Q 4 HOH 20  620 432 HOH HOH C . 
Q 4 HOH 21  621 105 HOH HOH C . 
Q 4 HOH 22  622 428 HOH HOH C . 
Q 4 HOH 23  623 423 HOH HOH C . 
Q 4 HOH 24  624 424 HOH HOH C . 
Q 4 HOH 25  625 439 HOH HOH C . 
Q 4 HOH 26  626 430 HOH HOH C . 
Q 4 HOH 27  627 440 HOH HOH C . 
Q 4 HOH 28  628 50  HOH HOH C . 
Q 4 HOH 29  629 156 HOH HOH C . 
Q 4 HOH 30  630 427 HOH HOH C . 
Q 4 HOH 31  631 232 HOH HOH C . 
Q 4 HOH 32  632 426 HOH HOH C . 
Q 4 HOH 33  633 448 HOH HOH C . 
Q 4 HOH 34  634 71  HOH HOH C . 
Q 4 HOH 35  635 429 HOH HOH C . 
Q 4 HOH 36  636 453 HOH HOH C . 
Q 4 HOH 37  637 452 HOH HOH C . 
Q 4 HOH 38  638 45  HOH HOH C . 
Q 4 HOH 39  639 133 HOH HOH C . 
Q 4 HOH 40  640 51  HOH HOH C . 
Q 4 HOH 41  641 234 HOH HOH C . 
Q 4 HOH 42  642 93  HOH HOH C . 
Q 4 HOH 43  643 442 HOH HOH C . 
Q 4 HOH 44  644 57  HOH HOH C . 
Q 4 HOH 45  645 462 HOH HOH C . 
Q 4 HOH 46  646 256 HOH HOH C . 
Q 4 HOH 47  647 190 HOH HOH C . 
Q 4 HOH 48  648 27  HOH HOH C . 
Q 4 HOH 49  649 469 HOH HOH C . 
Q 4 HOH 50  650 459 HOH HOH C . 
Q 4 HOH 51  651 446 HOH HOH C . 
Q 4 HOH 52  652 20  HOH HOH C . 
Q 4 HOH 53  653 96  HOH HOH C . 
Q 4 HOH 54  654 977 HOH HOH C . 
Q 4 HOH 55  655 408 HOH HOH C . 
Q 4 HOH 56  656 19  HOH HOH C . 
Q 4 HOH 57  657 84  HOH HOH C . 
Q 4 HOH 58  658 153 HOH HOH C . 
Q 4 HOH 59  659 119 HOH HOH C . 
Q 4 HOH 60  660 473 HOH HOH C . 
R 4 HOH 1   601 508 HOH HOH D . 
R 4 HOH 2   602 522 HOH HOH D . 
R 4 HOH 3   603 547 HOH HOH D . 
R 4 HOH 4   604 503 HOH HOH D . 
R 4 HOH 5   605 7   HOH HOH D . 
R 4 HOH 6   606 526 HOH HOH D . 
R 4 HOH 7   607 230 HOH HOH D . 
R 4 HOH 8   608 511 HOH HOH D . 
R 4 HOH 9   609 47  HOH HOH D . 
R 4 HOH 10  610 502 HOH HOH D . 
R 4 HOH 11  611 532 HOH HOH D . 
R 4 HOH 12  612 539 HOH HOH D . 
R 4 HOH 13  613 506 HOH HOH D . 
R 4 HOH 14  614 425 HOH HOH D . 
R 4 HOH 15  615 524 HOH HOH D . 
R 4 HOH 16  616 106 HOH HOH D . 
R 4 HOH 17  617 529 HOH HOH D . 
R 4 HOH 18  618 107 HOH HOH D . 
R 4 HOH 19  619 512 HOH HOH D . 
R 4 HOH 20  620 555 HOH HOH D . 
R 4 HOH 21  621 435 HOH HOH D . 
R 4 HOH 22  622 72  HOH HOH D . 
R 4 HOH 23  623 266 HOH HOH D . 
R 4 HOH 24  624 536 HOH HOH D . 
R 4 HOH 25  625 509 HOH HOH D . 
R 4 HOH 26  626 538 HOH HOH D . 
R 4 HOH 27  627 504 HOH HOH D . 
R 4 HOH 28  628 116 HOH HOH D . 
R 4 HOH 29  629 537 HOH HOH D . 
R 4 HOH 30  630 226 HOH HOH D . 
R 4 HOH 31  631 95  HOH HOH D . 
R 4 HOH 32  632 553 HOH HOH D . 
R 4 HOH 33  633 557 HOH HOH D . 
R 4 HOH 34  634 62  HOH HOH D . 
R 4 HOH 35  635 543 HOH HOH D . 
R 4 HOH 36  636 533 HOH HOH D . 
R 4 HOH 37  637 558 HOH HOH D . 
R 4 HOH 38  638 134 HOH HOH D . 
R 4 HOH 39  639 89  HOH HOH D . 
R 4 HOH 40  640 544 HOH HOH D . 
R 4 HOH 41  641 42  HOH HOH D . 
R 4 HOH 42  642 540 HOH HOH D . 
R 4 HOH 43  643 48  HOH HOH D . 
R 4 HOH 44  644 523 HOH HOH D . 
R 4 HOH 45  645 167 HOH HOH D . 
R 4 HOH 46  646 562 HOH HOH D . 
R 4 HOH 47  647 566 HOH HOH D . 
R 4 HOH 48  648 573 HOH HOH D . 
R 4 HOH 49  649 113 HOH HOH D . 
R 4 HOH 50  650 564 HOH HOH D . 
R 4 HOH 51  651 579 HOH HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0425 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2    ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        4 
# 
_cell.angle_alpha                  90 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9ESJ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     74.013 
_cell.length_a_esd                 ? 
_cell.length_b                     134.162 
_cell.length_b_esd                 ? 
_cell.length_c                     147.673 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9ESJ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9ESJ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.81 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.27 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'Protein at 10 mg/ml. 0.6 to 0.8 M KCl, 0.9 to 1.2 M (NH4)2SO4, and 100 mM HEPES pH 7.0' 
_exptl_crystal_grow.pdbx_pH_range   7-7.5 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-02-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.89842 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.89842 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9ESJ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.37 
_reflns.d_resolution_low                               99.498 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     57417 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           94.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.150 
_reflns.pdbx_Rpim_I_all                                0.056 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.139 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
10.33 99.30 ? 39.6 ? ? ? ? 850  ? ? ? ? ? ? ? ? ? ? ? 11.9 ? ? ? 0.041 0.056 ? 1 1 0.999 ? ? 99.8 ? 0.038 ? ? ? ? ? ? ? ? ? 
2.37  2.43  ? 1.9  ? ? ? ? 4648 ? ? ? ? ? ? ? ? ? ? ? 13.3 ? ? ? 1.349 0.513 ? 2 1 0.786 ? ? 100  ? 1.246 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            -1.410 
_refine.aniso_B[1][2]                            0.000 
_refine.aniso_B[1][3]                            0.000 
_refine.aniso_B[2][2]                            0.498 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            0.912 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               59.114 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.952 
_refine.correlation_coeff_Fo_to_Fc_free          0.943 
_refine.details                                  'Hydrogens have not been used' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9ESJ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.370 
_refine.ls_d_res_low                             99.498 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     53441 
_refine.ls_number_reflns_R_free                  2734 
_refine.ls_number_reflns_R_work                  50707 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    88.342 
_refine.ls_percent_reflns_R_free                 5.116 
_refine.ls_R_factor_all                          0.218 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2229 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2177 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      0.214 
_refine.ls_wR_factor_R_work                      0.206 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.459 
_refine.pdbx_overall_ESU_R_Free                  0.241 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    0.9433 
_refine.pdbx_average_fsc_free                    0.9448 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.370 
_refine_hist.d_res_low                        99.498 
_refine_hist.number_atoms_solvent             366 
_refine_hist.number_atoms_total               9282 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        8786 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         130 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.012  9207  ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 1.599  1.846  12504 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 5.999  5.000  1097  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 18.513 5.000  56    ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 14.940 10.000 1589  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 16.887 10.000 393   ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.096  0.200  1401  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.020  6917  ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.216  0.200  4518  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.314  0.200  6288  ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.155  0.200  462   ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.270  0.200  62    ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.154  0.200  10    ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 3.609  5.686  4391  ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 5.719  10.215 5487  ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.615  6.089  4816  ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 8.417  11.020 7017  ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 11.649 63.042 14354 ? r_lrange_it                    ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.370  2.432  4429 . 35  492  11.8988  . 3.696 . . 3.708 . . . . . 3.708 . 20 . 0.821 0.847 3.520 
'X-RAY DIFFRACTION' 2.432  2.498  4287 . 230 4056 99.9767  . 0.970 . . 0.968 . . . . . 1.036 . 20 . 0.669 0.698 0.997 
'X-RAY DIFFRACTION' 2.498  2.571  4170 . 225 3945 100.0000 . 0.564 . . 0.564 . . . . . 0.608 . 20 . 0.935 0.940 0.564 
'X-RAY DIFFRACTION' 2.571  2.650  4083 . 198 3884 99.9755  . 0.262 . . 0.263 . . . . . 0.253 . 20 . 0.954 0.960 0.242 
'X-RAY DIFFRACTION' 2.650  2.736  3985 . 118 2249 59.3977  . 0.256 . . 0.257 . . . . . 0.244 . 20 . 0.959 0.963 0.236 
'X-RAY DIFFRACTION' 2.736  2.832  3787 . 190 3597 100.0000 . 0.241 . . 0.241 . . . . . 0.230 . 20 . 0.963 0.967 0.236 
'X-RAY DIFFRACTION' 2.832  2.939  3685 . 181 3503 99.9729  . 0.243 . . 0.242 . . . . . 0.229 . 20 . 0.963 0.960 0.252 
'X-RAY DIFFRACTION' 2.939  3.059  3575 . 196 3379 100.0000 . 0.240 . . 0.241 . . . . . 0.229 . 20 . 0.966 0.969 0.236 
'X-RAY DIFFRACTION' 3.059  3.195  3421 . 176 3245 100.0000 . 0.230 . . 0.232 . . . . . 0.220 . 20 . 0.968 0.975 0.201 
'X-RAY DIFFRACTION' 3.195  3.351  3280 . 160 3120 100.0000 . 0.211 . . 0.211 . . . . . 0.203 . 20 . 0.975 0.974 0.220 
'X-RAY DIFFRACTION' 3.351  3.532  3107 . 114 2152 72.9321  . 0.204 . . 0.204 . . . . . 0.197 . 20 . 0.977 0.982 0.200 
'X-RAY DIFFRACTION' 3.532  3.746  2969 . 123 2162 76.9619  . 0.190 . . 0.190 . . . . . 0.184 . 20 . 0.980 0.983 0.185 
'X-RAY DIFFRACTION' 3.746  4.004  2782 . 135 2647 100.0000 . 0.180 . . 0.180 . . . . . 0.175 . 20 . 0.982 0.983 0.173 
'X-RAY DIFFRACTION' 4.004  4.324  2608 . 140 2468 100.0000 . 0.156 . . 0.157 . . . . . 0.153 . 20 . 0.986 0.989 0.149 
'X-RAY DIFFRACTION' 4.324  4.736  2407 . 131 2276 100.0000 . 0.148 . . 0.147 . . . . . 0.144 . 20 . 0.987 0.985 0.161 
'X-RAY DIFFRACTION' 4.736  5.294  2192 . 91  2100 99.9544  . 0.170 . . 0.171 . . . . . 0.167 . 20 . 0.983 0.984 0.163 
'X-RAY DIFFRACTION' 5.294  6.110  1952 . 103 1849 100.0000 . 0.211 . . 0.208 . . . . . 0.203 . 20 . 0.977 0.965 0.254 
'X-RAY DIFFRACTION' 6.110  7.476  1662 . 91  1570 99.9398  . 0.217 . . 0.215 . . . . . 0.210 . 20 . 0.978 0.969 0.249 
'X-RAY DIFFRACTION' 7.476  10.542 1326 . 59  1267 100.0000 . 0.152 . . 0.152 . . . . . 0.157 . 20 . 0.987 0.990 0.144 
'X-RAY DIFFRACTION' 10.542 99.498 786  . 38  746  99.7455  . 0.244 . . 0.242 . . . . . 0.257 . 20 . 0.963 0.898 0.305 
# 
_struct.entry_id                     9ESJ 
_struct.title                        'CDK2-cyclin A in complex with FragLite 31' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9ESJ 
_struct_keywords.text            'cyclin-dependent kinase, FragLite, CDK2, cyclin A, Fragment, CELL CYCLE' 
_struct_keywords.pdbx_keywords   'CELL CYCLE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 3 ? 
I N N 3 ? 
J N N 3 ? 
K N N 3 ? 
L N N 3 ? 
M N N 3 ? 
N N N 3 ? 
O N N 4 ? 
P N N 4 ? 
Q N N 4 ? 
R N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP CDK2_HUMAN  P24941 ? 1 
;MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
;
1   
2 UNP CCNA2_BOVIN P30274 ? 2 
;VNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRG
KLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVES
LAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIRE
KYKNSKYHGVSLLNPPETLNV
;
170 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9ESJ A 5 ? 302 ? P24941 1   ? 298 ? 1   298 
2 2 9ESJ B 2 ? 262 ? P30274 170 ? 430 ? 172 432 
3 1 9ESJ C 5 ? 302 ? P24941 1   ? 298 ? 1   298 
4 2 9ESJ D 2 ? 262 ? P30274 170 ? 430 ? 172 432 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9ESJ GLY A 1   ? UNP P24941 ? ? 'expression tag' -3  1  
1 9ESJ PRO A 2   ? UNP P24941 ? ? 'expression tag' -2  2  
1 9ESJ GLY A 3   ? UNP P24941 ? ? 'expression tag' -1  3  
1 9ESJ SER A 4   ? UNP P24941 ? ? 'expression tag' 0   4  
2 9ESJ GLY B 1   ? UNP P30274 ? ? 'expression tag' 171 5  
2 9ESJ HIS B 263 ? UNP P30274 ? ? 'expression tag' 433 6  
2 9ESJ HIS B 264 ? UNP P30274 ? ? 'expression tag' 434 7  
2 9ESJ HIS B 265 ? UNP P30274 ? ? 'expression tag' 435 8  
2 9ESJ HIS B 266 ? UNP P30274 ? ? 'expression tag' 436 9  
2 9ESJ HIS B 267 ? UNP P30274 ? ? 'expression tag' 437 10 
2 9ESJ HIS B 268 ? UNP P30274 ? ? 'expression tag' 438 11 
3 9ESJ GLY C 1   ? UNP P24941 ? ? 'expression tag' -3  12 
3 9ESJ PRO C 2   ? UNP P24941 ? ? 'expression tag' -2  13 
3 9ESJ GLY C 3   ? UNP P24941 ? ? 'expression tag' -1  14 
3 9ESJ SER C 4   ? UNP P24941 ? ? 'expression tag' 0   15 
4 9ESJ GLY D 1   ? UNP P30274 ? ? 'expression tag' 171 16 
4 9ESJ HIS D 263 ? UNP P30274 ? ? 'expression tag' 433 17 
4 9ESJ HIS D 264 ? UNP P30274 ? ? 'expression tag' 434 18 
4 9ESJ HIS D 265 ? UNP P30274 ? ? 'expression tag' 435 19 
4 9ESJ HIS D 266 ? UNP P30274 ? ? 'expression tag' 436 20 
4 9ESJ HIS D 267 ? UNP P30274 ? ? 'expression tag' 437 21 
4 9ESJ HIS D 268 ? UNP P30274 ? ? 'expression tag' 438 22 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3780  ? 
1 MORE         -18   ? 
1 'SSA (A^2)'  23380 ? 
2 'ABSA (A^2)' 3680  ? 
2 MORE         -17   ? 
2 'SSA (A^2)'  22510 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,E,F,G,H,I,J,O,P 
2 1 C,D,K,L,M,N,Q,R     
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 4   ? GLU A 6   ? SER A 0   GLU A 2   5 ? 3  
HELX_P HELX_P2  AA2 PRO A 49  ? LEU A 62  ? PRO A 45  LEU A 58  1 ? 14 
HELX_P HELX_P3  AA3 LEU A 91  ? SER A 98  ? LEU A 87  SER A 94  1 ? 8  
HELX_P HELX_P4  AA4 PRO A 104 ? HIS A 125 ? PRO A 100 HIS A 121 1 ? 22 
HELX_P HELX_P5  AA5 LYS A 133 ? GLN A 135 ? LYS A 129 GLN A 131 5 ? 3  
HELX_P HELX_P6  AA6 ASP A 149 ? ALA A 153 ? ASP A 145 ALA A 149 5 ? 5  
HELX_P HELX_P7  AA7 THR A 169 ? ARG A 173 ? THR A 165 ARG A 169 5 ? 5  
HELX_P HELX_P8  AA8 ALA A 174 ? LEU A 179 ? ALA A 170 LEU A 175 1 ? 6  
HELX_P HELX_P9  AA9 THR A 186 ? ARG A 203 ? THR A 182 ARG A 199 1 ? 18 
HELX_P HELX_P10 AB1 SER A 211 ? GLY A 224 ? SER A 207 GLY A 220 1 ? 14 
HELX_P HELX_P11 AB2 GLY A 233 ? MET A 237 ? GLY A 229 MET A 233 5 ? 5  
HELX_P HELX_P12 AB3 ASP A 260 ? LEU A 271 ? ASP A 256 LEU A 267 1 ? 12 
HELX_P HELX_P13 AB4 SER A 280 ? LEU A 285 ? SER A 276 LEU A 281 1 ? 6  
HELX_P HELX_P14 AB5 ALA A 286 ? GLN A 291 ? ALA A 282 GLN A 287 5 ? 6  
HELX_P HELX_P15 AB6 GLY B 1   ? VAL B 5   ? GLY B 171 VAL B 175 5 ? 5  
HELX_P HELX_P16 AB7 TYR B 8   ? CYS B 23  ? TYR B 178 CYS B 193 1 ? 16 
HELX_P HELX_P17 AB8 THR B 37  ? TYR B 55  ? THR B 207 TYR B 225 1 ? 19 
HELX_P HELX_P18 AB9 GLN B 58  ? MET B 76  ? GLN B 228 MET B 246 1 ? 19 
HELX_P HELX_P19 AC1 LEU B 79  ? GLY B 81  ? LEU B 249 GLY B 251 5 ? 3  
HELX_P HELX_P20 AC2 LYS B 82  ? GLU B 99  ? LYS B 252 GLU B 269 1 ? 18 
HELX_P HELX_P21 AC3 GLU B 104 ? ILE B 111 ? GLU B 274 ILE B 281 1 ? 8  
HELX_P HELX_P22 AC4 THR B 117 ? LEU B 132 ? THR B 287 LEU B 302 1 ? 16 
HELX_P HELX_P23 AC5 THR B 140 ? LEU B 150 ? THR B 310 LEU B 320 1 ? 11 
HELX_P HELX_P24 AC6 ASN B 156 ? ASP B 173 ? ASN B 326 ASP B 343 1 ? 18 
HELX_P HELX_P25 AC7 ASP B 173 ? LEU B 178 ? ASP B 343 LEU B 348 1 ? 6  
HELX_P HELX_P26 AC8 LEU B 181 ? GLY B 199 ? LEU B 351 GLY B 369 1 ? 19 
HELX_P HELX_P27 AC9 PRO B 203 ? GLY B 211 ? PRO B 373 GLY B 381 1 ? 9  
HELX_P HELX_P28 AD1 THR B 213 ? ALA B 231 ? THR B 383 ALA B 401 1 ? 19 
HELX_P HELX_P29 AD2 GLN B 237 ? TYR B 243 ? GLN B 407 TYR B 413 1 ? 7  
HELX_P HELX_P30 AD3 LYS B 244 ? HIS B 249 ? LYS B 414 HIS B 419 5 ? 6  
HELX_P HELX_P31 AD4 GLY B 250 ? LEU B 254 ? GLY B 420 LEU B 424 5 ? 5  
HELX_P HELX_P32 AD5 PRO C 49  ? LEU C 62  ? PRO C 45  LEU C 58  1 ? 14 
HELX_P HELX_P33 AD6 LEU C 91  ? SER C 98  ? LEU C 87  SER C 94  1 ? 8  
HELX_P HELX_P34 AD7 PRO C 104 ? HIS C 125 ? PRO C 100 HIS C 121 1 ? 22 
HELX_P HELX_P35 AD8 LYS C 133 ? GLN C 135 ? LYS C 129 GLN C 131 5 ? 3  
HELX_P HELX_P36 AD9 THR C 169 ? ARG C 173 ? THR C 165 ARG C 169 5 ? 5  
HELX_P HELX_P37 AE1 ALA C 174 ? LEU C 179 ? ALA C 170 LEU C 175 1 ? 6  
HELX_P HELX_P38 AE2 THR C 186 ? ARG C 203 ? THR C 182 ARG C 199 1 ? 18 
HELX_P HELX_P39 AE3 SER C 211 ? GLY C 224 ? SER C 207 GLY C 220 1 ? 14 
HELX_P HELX_P40 AE4 ASP C 260 ? LEU C 271 ? ASP C 256 LEU C 267 1 ? 12 
HELX_P HELX_P41 AE5 SER C 280 ? HIS C 287 ? SER C 276 HIS C 283 1 ? 8  
HELX_P HELX_P42 AE6 PRO C 288 ? GLN C 291 ? PRO C 284 GLN C 287 5 ? 4  
HELX_P HELX_P43 AE7 GLY D 1   ? VAL D 5   ? GLY D 171 VAL D 175 5 ? 5  
HELX_P HELX_P44 AE8 TYR D 8   ? CYS D 23  ? TYR D 178 CYS D 193 1 ? 16 
HELX_P HELX_P45 AE9 GLY D 28  ? GLN D 33  ? GLY D 198 GLN D 203 1 ? 6  
HELX_P HELX_P46 AF1 THR D 37  ? TYR D 55  ? THR D 207 TYR D 225 1 ? 19 
HELX_P HELX_P47 AF2 GLN D 58  ? MET D 76  ? GLN D 228 MET D 246 1 ? 19 
HELX_P HELX_P48 AF3 LEU D 79  ? GLY D 81  ? LEU D 249 GLY D 251 5 ? 3  
HELX_P HELX_P49 AF4 LYS D 82  ? GLU D 99  ? LYS D 252 GLU D 269 1 ? 18 
HELX_P HELX_P50 AF5 GLU D 104 ? ILE D 111 ? GLU D 274 ILE D 281 1 ? 8  
HELX_P HELX_P51 AF6 THR D 117 ? LEU D 132 ? THR D 287 LEU D 302 1 ? 16 
HELX_P HELX_P52 AF7 THR D 140 ? PHE D 149 ? THR D 310 PHE D 319 1 ? 10 
HELX_P HELX_P53 AF8 LEU D 150 ? GLN D 152 ? LEU D 320 GLN D 322 5 ? 3  
HELX_P HELX_P54 AF9 ASN D 156 ? ASP D 173 ? ASN D 326 ASP D 343 1 ? 18 
HELX_P HELX_P55 AG1 ASP D 173 ? LEU D 178 ? ASP D 343 LEU D 348 1 ? 6  
HELX_P HELX_P56 AG2 LEU D 181 ? GLY D 199 ? LEU D 351 GLY D 369 1 ? 19 
HELX_P HELX_P57 AG3 PRO D 203 ? GLY D 211 ? PRO D 373 GLY D 381 1 ? 9  
HELX_P HELX_P58 AG4 THR D 213 ? ALA D 231 ? THR D 383 ALA D 401 1 ? 19 
HELX_P HELX_P59 AG5 PRO D 232 ? HIS D 234 ? PRO D 402 HIS D 404 5 ? 3  
HELX_P HELX_P60 AG6 GLN D 237 ? TYR D 243 ? GLN D 407 TYR D 413 1 ? 7  
HELX_P HELX_P61 AG7 LYS D 244 ? HIS D 249 ? LYS D 414 HIS D 419 5 ? 6  
HELX_P HELX_P62 AG8 GLY D 250 ? LEU D 254 ? GLY D 420 LEU D 424 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A TYR 163 C ? ? ? 1_555 A TPO 164 N ? ? A TYR 159 A TPO 160 1_555 ? ? ? ? ? ? ? 1.336 ? ? 
covale2 covale both ? A TPO 164 C ? ? ? 1_555 A HIS 165 N ? ? A TPO 160 A HIS 161 1_555 ? ? ? ? ? ? ? 1.338 ? ? 
covale3 covale both ? C TYR 163 C ? ? ? 1_555 C TPO 164 N ? ? C TYR 159 C TPO 160 1_555 ? ? ? ? ? ? ? 1.346 ? ? 
covale4 covale both ? C TPO 164 C ? ? ? 1_555 C HIS 165 N ? ? C TPO 160 C HIS 161 1_555 ? ? ? ? ? ? ? 1.339 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 TPO A 164 ? . . . . TPO A 160 ? 1_555 . . . . . . . THR 1 TPO Phosphorylation 'Named protein modification' 
2 TPO C 164 ? . . . . TPO C 160 ? 1_555 . . . . . . . THR 1 TPO Phosphorylation 'Named protein modification' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 VAL 158 A . ? VAL 154 A PRO 159 A ? PRO 155 A 1 -7.64 
2 GLN 153 B . ? GLN 323 B PRO 154 B ? PRO 324 B 1 -7.77 
3 ASP 175 B . ? ASP 345 B PRO 176 B ? PRO 346 B 1 13.04 
4 VAL 158 C . ? VAL 154 C PRO 159 C ? PRO 155 C 1 -5.19 
5 GLN 153 D . ? GLN 323 D PRO 154 D ? PRO 324 D 1 -8.88 
6 ASP 175 D . ? ASP 345 D PRO 176 D ? PRO 346 D 1 9.99  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 5 ? 
AA5 ? 3 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 8   ? GLY A 17  ? PHE A 4   GLY A 13  
AA1 2 GLY A 20  ? ASN A 27  ? GLY A 16  ASN A 23  
AA1 3 VAL A 33  ? ARG A 40  ? VAL A 29  ARG A 36  
AA1 4 LYS A 79  ? GLU A 85  ? LYS A 75  GLU A 81  
AA1 5 LEU A 70  ? HIS A 75  ? LEU A 66  HIS A 71  
AA2 1 GLN A 89  ? ASP A 90  ? GLN A 85  ASP A 86  
AA2 2 LEU A 137 ? ILE A 139 ? LEU A 133 ILE A 135 
AA2 3 ILE A 145 ? LEU A 147 ? ILE A 141 LEU A 143 
AA3 1 VAL A 127 ? LEU A 128 ? VAL A 123 LEU A 124 
AA3 2 ARG A 154 ? ALA A 155 ? ARG A 150 ALA A 151 
AA4 1 PHE C 8   ? GLU C 16  ? PHE C 4   GLU C 12  
AA4 2 GLY C 20  ? ASN C 27  ? GLY C 16  ASN C 23  
AA4 3 VAL C 33  ? ARG C 40  ? VAL C 29  ARG C 36  
AA4 4 LYS C 79  ? GLU C 85  ? LYS C 75  GLU C 81  
AA4 5 LEU C 70  ? HIS C 75  ? LEU C 66  HIS C 71  
AA5 1 GLN C 89  ? ASP C 90  ? GLN C 85  ASP C 86  
AA5 2 LEU C 137 ? ILE C 139 ? LEU C 133 ILE C 135 
AA5 3 ILE C 145 ? LEU C 147 ? ILE C 141 LEU C 143 
AA6 1 VAL C 127 ? LEU C 128 ? VAL C 123 LEU C 124 
AA6 2 ARG C 154 ? ALA C 155 ? ARG C 150 ALA C 151 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 15  ? N GLY A 11  O VAL A 22  ? O VAL A 18  
AA1 2 3 N ALA A 25  ? N ALA A 21  O VAL A 34  ? O VAL A 30  
AA1 3 4 N ILE A 39  ? N ILE A 35  O LEU A 80  ? O LEU A 76  
AA1 4 5 O VAL A 83  ? O VAL A 79  N LEU A 71  ? N LEU A 67  
AA2 1 2 N GLN A 89  ? N GLN A 85  O ILE A 139 ? O ILE A 135 
AA2 2 3 N LEU A 138 ? N LEU A 134 O LYS A 146 ? O LYS A 142 
AA3 1 2 N LEU A 128 ? N LEU A 124 O ARG A 154 ? O ARG A 150 
AA4 1 2 N ILE C 14  ? N ILE C 10  O VAL C 22  ? O VAL C 18  
AA4 2 3 N ALA C 25  ? N ALA C 21  O VAL C 34  ? O VAL C 30  
AA4 3 4 N LYS C 37  ? N LYS C 33  O LEU C 82  ? O LEU C 78  
AA4 4 5 O VAL C 83  ? O VAL C 79  N LEU C 71  ? N LEU C 67  
AA5 1 2 N GLN C 89  ? N GLN C 85  O ILE C 139 ? O ILE C 135 
AA5 2 3 N LEU C 138 ? N LEU C 134 O LYS C 146 ? O LYS C 142 
AA6 1 2 N LEU C 128 ? N LEU C 124 O ARG C 154 ? O ARG C 150 
# 
_pdbx_entry_details.entry_id                   9ESJ 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             N 
_pdbx_validate_rmsd_angle.auth_asym_id_1             B 
_pdbx_validate_rmsd_angle.auth_comp_id_1             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_1              346 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_2             B 
_pdbx_validate_rmsd_angle.auth_comp_id_2             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_2              346 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_3             B 
_pdbx_validate_rmsd_angle.auth_comp_id_3             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_3              346 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                90.10 
_pdbx_validate_rmsd_angle.angle_target_value         102.60 
_pdbx_validate_rmsd_angle.angle_deviation            -12.50 
_pdbx_validate_rmsd_angle.angle_standard_deviation   1.10 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 TYR A 15  ? ? -97.74  46.56   
2  1 ASP A 38  ? ? 54.74   17.00   
3  1 SER A 94  ? ? -91.47  33.25   
4  1 ASP A 127 ? ? -158.26 44.49   
5  1 ASP A 145 ? ? 52.74   75.68   
6  1 VAL A 164 ? ? 79.14   127.92  
7  1 SER A 181 ? ? -140.97 -159.89 
8  1 VAL B 175 ? ? 35.27   65.80   
9  1 TRP B 372 ? ? -32.50  114.30  
10 1 THR C 41  ? ? -141.10 -81.37  
11 1 ASP C 127 ? ? -149.96 45.90   
12 1 ASP C 145 ? ? 40.67   80.80   
13 1 VAL C 164 ? ? 72.98   130.17  
14 1 SER C 181 ? ? -143.06 -150.35 
15 1 LYS C 250 ? ? -109.57 61.42   
16 1 PRO C 254 ? ? -65.73  2.74    
17 1 THR C 290 ? ? -117.67 -166.34 
18 1 VAL D 175 ? ? 27.10   68.25   
19 1 HIS D 321 ? ? -96.33  30.62   
20 1 GLN D 323 ? ? -165.53 102.71  
21 1 PRO D 324 ? ? -75.58  -163.40 
22 1 TRP D 372 ? ? -41.36  106.38  
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 50  ? ? 0.092 'SIDE CHAIN' 
2 1 ARG A 150 ? ? 0.256 'SIDE CHAIN' 
3 1 ARG A 245 ? ? 0.076 'SIDE CHAIN' 
4 1 ARG C 36  ? ? 0.205 'SIDE CHAIN' 
5 1 ARG C 150 ? ? 0.249 'SIDE CHAIN' 
6 1 ARG C 157 ? ? 0.084 'SIDE CHAIN' 
7 1 ARG C 217 ? ? 0.155 'SIDE CHAIN' 
8 1 ARG D 293 ? ? 0.075 'SIDE CHAIN' 
# 
loop_
_pdbx_struct_mod_residue.id 
_pdbx_struct_mod_residue.label_asym_id 
_pdbx_struct_mod_residue.label_comp_id 
_pdbx_struct_mod_residue.label_seq_id 
_pdbx_struct_mod_residue.auth_asym_id 
_pdbx_struct_mod_residue.auth_comp_id 
_pdbx_struct_mod_residue.auth_seq_id 
_pdbx_struct_mod_residue.PDB_ins_code 
_pdbx_struct_mod_residue.parent_comp_id 
_pdbx_struct_mod_residue.details 
1 A TPO 164 A TPO 160 ? THR 'modified residue' 
2 C TPO 164 C TPO 160 ? THR 'modified residue' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ARG 297 ? A ARG 301 
2  1 Y 1 A LEU 298 ? A LEU 302 
3  1 Y 1 B HIS 433 ? B HIS 263 
4  1 Y 1 B HIS 434 ? B HIS 264 
5  1 Y 1 B HIS 435 ? B HIS 265 
6  1 Y 1 B HIS 436 ? B HIS 266 
7  1 Y 1 B HIS 437 ? B HIS 267 
8  1 Y 1 B HIS 438 ? B HIS 268 
9  1 Y 1 C GLY -3  ? C GLY 1   
10 1 Y 1 C PRO -2  ? C PRO 2   
11 1 Y 1 C GLY -1  ? C GLY 3   
12 1 Y 1 C PRO 222 ? C PRO 226 
13 1 Y 1 C ASP 223 ? C ASP 227 
14 1 Y 1 C GLU 224 ? C GLU 228 
15 1 Y 1 C VAL 225 ? C VAL 229 
16 1 Y 1 C VAL 226 ? C VAL 230 
17 1 Y 1 C TRP 227 ? C TRP 231 
18 1 Y 1 C PRO 228 ? C PRO 232 
19 1 Y 1 C GLY 229 ? C GLY 233 
20 1 Y 1 C VAL 230 ? C VAL 234 
21 1 Y 1 C THR 231 ? C THR 235 
22 1 Y 1 C SER 232 ? C SER 236 
23 1 Y 1 C MET 233 ? C MET 237 
24 1 Y 1 C PRO 234 ? C PRO 238 
25 1 Y 1 C ASP 235 ? C ASP 239 
26 1 Y 1 C TYR 236 ? C TYR 240 
27 1 Y 1 C LYS 237 ? C LYS 241 
28 1 Y 1 C PRO 238 ? C PRO 242 
29 1 Y 1 C SER 239 ? C SER 243 
30 1 Y 1 C PHE 240 ? C PHE 244 
31 1 Y 1 C PRO 241 ? C PRO 245 
32 1 Y 1 C LYS 242 ? C LYS 246 
33 1 Y 1 C TRP 243 ? C TRP 247 
34 1 Y 1 C ALA 244 ? C ALA 248 
35 1 Y 1 C ARG 245 ? C ARG 249 
36 1 Y 1 C GLN 246 ? C GLN 250 
37 1 Y 1 C ASP 247 ? C ASP 251 
38 1 Y 1 C PHE 248 ? C PHE 252 
39 1 Y 1 C ARG 297 ? C ARG 301 
40 1 Y 1 C LEU 298 ? C LEU 302 
41 1 Y 1 D HIS 433 ? D HIS 263 
42 1 Y 1 D HIS 434 ? D HIS 264 
43 1 Y 1 D HIS 435 ? D HIS 265 
44 1 Y 1 D HIS 436 ? D HIS 266 
45 1 Y 1 D HIS 437 ? D HIS 267 
46 1 Y 1 D HIS 438 ? D HIS 268 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HHT C4   C  Y N 137 
HHT C5   C  Y N 138 
HHT C6   C  Y N 139 
HHT C7   C  Y N 140 
HHT C8   C  N N 141 
HHT C9   C  N N 142 
HHT C3   C  Y N 143 
HHT C1   C  N N 144 
HHT O1   O  N N 145 
HHT C2   C  Y N 146 
HHT BR1  BR N N 147 
HHT O2   O  N N 148 
HHT O3   O  N N 149 
HHT H1   H  N N 150 
HHT H2   H  N N 151 
HHT H3   H  N N 152 
HHT H4   H  N N 153 
HHT H5   H  N N 154 
HHT H6   H  N N 155 
HHT H7   H  N N 156 
HHT H8   H  N N 157 
HHT H9   H  N N 158 
HIS N    N  N N 159 
HIS CA   C  N S 160 
HIS C    C  N N 161 
HIS O    O  N N 162 
HIS CB   C  N N 163 
HIS CG   C  Y N 164 
HIS ND1  N  Y N 165 
HIS CD2  C  Y N 166 
HIS CE1  C  Y N 167 
HIS NE2  N  Y N 168 
HIS OXT  O  N N 169 
HIS H    H  N N 170 
HIS H2   H  N N 171 
HIS HA   H  N N 172 
HIS HB2  H  N N 173 
HIS HB3  H  N N 174 
HIS HD1  H  N N 175 
HIS HD2  H  N N 176 
HIS HE1  H  N N 177 
HIS HE2  H  N N 178 
HIS HXT  H  N N 179 
HOH O    O  N N 180 
HOH H1   H  N N 181 
HOH H2   H  N N 182 
ILE N    N  N N 183 
ILE CA   C  N S 184 
ILE C    C  N N 185 
ILE O    O  N N 186 
ILE CB   C  N S 187 
ILE CG1  C  N N 188 
ILE CG2  C  N N 189 
ILE CD1  C  N N 190 
ILE OXT  O  N N 191 
ILE H    H  N N 192 
ILE H2   H  N N 193 
ILE HA   H  N N 194 
ILE HB   H  N N 195 
ILE HG12 H  N N 196 
ILE HG13 H  N N 197 
ILE HG21 H  N N 198 
ILE HG22 H  N N 199 
ILE HG23 H  N N 200 
ILE HD11 H  N N 201 
ILE HD12 H  N N 202 
ILE HD13 H  N N 203 
ILE HXT  H  N N 204 
LEU N    N  N N 205 
LEU CA   C  N S 206 
LEU C    C  N N 207 
LEU O    O  N N 208 
LEU CB   C  N N 209 
LEU CG   C  N N 210 
LEU CD1  C  N N 211 
LEU CD2  C  N N 212 
LEU OXT  O  N N 213 
LEU H    H  N N 214 
LEU H2   H  N N 215 
LEU HA   H  N N 216 
LEU HB2  H  N N 217 
LEU HB3  H  N N 218 
LEU HG   H  N N 219 
LEU HD11 H  N N 220 
LEU HD12 H  N N 221 
LEU HD13 H  N N 222 
LEU HD21 H  N N 223 
LEU HD22 H  N N 224 
LEU HD23 H  N N 225 
LEU HXT  H  N N 226 
LYS N    N  N N 227 
LYS CA   C  N S 228 
LYS C    C  N N 229 
LYS O    O  N N 230 
LYS CB   C  N N 231 
LYS CG   C  N N 232 
LYS CD   C  N N 233 
LYS CE   C  N N 234 
LYS NZ   N  N N 235 
LYS OXT  O  N N 236 
LYS H    H  N N 237 
LYS H2   H  N N 238 
LYS HA   H  N N 239 
LYS HB2  H  N N 240 
LYS HB3  H  N N 241 
LYS HG2  H  N N 242 
LYS HG3  H  N N 243 
LYS HD2  H  N N 244 
LYS HD3  H  N N 245 
LYS HE2  H  N N 246 
LYS HE3  H  N N 247 
LYS HZ1  H  N N 248 
LYS HZ2  H  N N 249 
LYS HZ3  H  N N 250 
LYS HXT  H  N N 251 
MET N    N  N N 252 
MET CA   C  N S 253 
MET C    C  N N 254 
MET O    O  N N 255 
MET CB   C  N N 256 
MET CG   C  N N 257 
MET SD   S  N N 258 
MET CE   C  N N 259 
MET OXT  O  N N 260 
MET H    H  N N 261 
MET H2   H  N N 262 
MET HA   H  N N 263 
MET HB2  H  N N 264 
MET HB3  H  N N 265 
MET HG2  H  N N 266 
MET HG3  H  N N 267 
MET HE1  H  N N 268 
MET HE2  H  N N 269 
MET HE3  H  N N 270 
MET HXT  H  N N 271 
PHE N    N  N N 272 
PHE CA   C  N S 273 
PHE C    C  N N 274 
PHE O    O  N N 275 
PHE CB   C  N N 276 
PHE CG   C  Y N 277 
PHE CD1  C  Y N 278 
PHE CD2  C  Y N 279 
PHE CE1  C  Y N 280 
PHE CE2  C  Y N 281 
PHE CZ   C  Y N 282 
PHE OXT  O  N N 283 
PHE H    H  N N 284 
PHE H2   H  N N 285 
PHE HA   H  N N 286 
PHE HB2  H  N N 287 
PHE HB3  H  N N 288 
PHE HD1  H  N N 289 
PHE HD2  H  N N 290 
PHE HE1  H  N N 291 
PHE HE2  H  N N 292 
PHE HZ   H  N N 293 
PHE HXT  H  N N 294 
PRO N    N  N N 295 
PRO CA   C  N S 296 
PRO C    C  N N 297 
PRO O    O  N N 298 
PRO CB   C  N N 299 
PRO CG   C  N N 300 
PRO CD   C  N N 301 
PRO OXT  O  N N 302 
PRO H    H  N N 303 
PRO HA   H  N N 304 
PRO HB2  H  N N 305 
PRO HB3  H  N N 306 
PRO HG2  H  N N 307 
PRO HG3  H  N N 308 
PRO HD2  H  N N 309 
PRO HD3  H  N N 310 
PRO HXT  H  N N 311 
SER N    N  N N 312 
SER CA   C  N S 313 
SER C    C  N N 314 
SER O    O  N N 315 
SER CB   C  N N 316 
SER OG   O  N N 317 
SER OXT  O  N N 318 
SER H    H  N N 319 
SER H2   H  N N 320 
SER HA   H  N N 321 
SER HB2  H  N N 322 
SER HB3  H  N N 323 
SER HG   H  N N 324 
SER HXT  H  N N 325 
THR N    N  N N 326 
THR CA   C  N S 327 
THR C    C  N N 328 
THR O    O  N N 329 
THR CB   C  N R 330 
THR OG1  O  N N 331 
THR CG2  C  N N 332 
THR OXT  O  N N 333 
THR H    H  N N 334 
THR H2   H  N N 335 
THR HA   H  N N 336 
THR HB   H  N N 337 
THR HG1  H  N N 338 
THR HG21 H  N N 339 
THR HG22 H  N N 340 
THR HG23 H  N N 341 
THR HXT  H  N N 342 
TPO N    N  N N 343 
TPO CA   C  N S 344 
TPO CB   C  N R 345 
TPO CG2  C  N N 346 
TPO OG1  O  N N 347 
TPO P    P  N N 348 
TPO O1P  O  N N 349 
TPO O2P  O  N N 350 
TPO O3P  O  N N 351 
TPO C    C  N N 352 
TPO O    O  N N 353 
TPO OXT  O  N N 354 
TPO H    H  N N 355 
TPO H2   H  N N 356 
TPO HA   H  N N 357 
TPO HB   H  N N 358 
TPO HG21 H  N N 359 
TPO HG22 H  N N 360 
TPO HG23 H  N N 361 
TPO HOP2 H  N N 362 
TPO HOP3 H  N N 363 
TPO HXT  H  N N 364 
TRP N    N  N N 365 
TRP CA   C  N S 366 
TRP C    C  N N 367 
TRP O    O  N N 368 
TRP CB   C  N N 369 
TRP CG   C  Y N 370 
TRP CD1  C  Y N 371 
TRP CD2  C  Y N 372 
TRP NE1  N  Y N 373 
TRP CE2  C  Y N 374 
TRP CE3  C  Y N 375 
TRP CZ2  C  Y N 376 
TRP CZ3  C  Y N 377 
TRP CH2  C  Y N 378 
TRP OXT  O  N N 379 
TRP H    H  N N 380 
TRP H2   H  N N 381 
TRP HA   H  N N 382 
TRP HB2  H  N N 383 
TRP HB3  H  N N 384 
TRP HD1  H  N N 385 
TRP HE1  H  N N 386 
TRP HE3  H  N N 387 
TRP HZ2  H  N N 388 
TRP HZ3  H  N N 389 
TRP HH2  H  N N 390 
TRP HXT  H  N N 391 
TYR N    N  N N 392 
TYR CA   C  N S 393 
TYR C    C  N N 394 
TYR O    O  N N 395 
TYR CB   C  N N 396 
TYR CG   C  Y N 397 
TYR CD1  C  Y N 398 
TYR CD2  C  Y N 399 
TYR CE1  C  Y N 400 
TYR CE2  C  Y N 401 
TYR CZ   C  Y N 402 
TYR OH   O  N N 403 
TYR OXT  O  N N 404 
TYR H    H  N N 405 
TYR H2   H  N N 406 
TYR HA   H  N N 407 
TYR HB2  H  N N 408 
TYR HB3  H  N N 409 
TYR HD1  H  N N 410 
TYR HD2  H  N N 411 
TYR HE1  H  N N 412 
TYR HE2  H  N N 413 
TYR HH   H  N N 414 
TYR HXT  H  N N 415 
VAL N    N  N N 416 
VAL CA   C  N S 417 
VAL C    C  N N 418 
VAL O    O  N N 419 
VAL CB   C  N N 420 
VAL CG1  C  N N 421 
VAL CG2  C  N N 422 
VAL OXT  O  N N 423 
VAL H    H  N N 424 
VAL H2   H  N N 425 
VAL HA   H  N N 426 
VAL HB   H  N N 427 
VAL HG11 H  N N 428 
VAL HG12 H  N N 429 
VAL HG13 H  N N 430 
VAL HG21 H  N N 431 
VAL HG22 H  N N 432 
VAL HG23 H  N N 433 
VAL HXT  H  N N 434 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HHT O3  C9   doub N N 129 
HHT O2  C9   sing N N 130 
HHT C9  C8   sing N N 131 
HHT C8  C7   sing N N 132 
HHT C7  C6   doub Y N 133 
HHT C7  C2   sing Y N 134 
HHT O1  C2   sing N N 135 
HHT O1  C1   sing N N 136 
HHT C6  C5   sing Y N 137 
HHT C2  C3   doub Y N 138 
HHT C5  C4   doub Y N 139 
HHT C3  C4   sing Y N 140 
HHT C4  BR1  sing N N 141 
HHT C5  H1   sing N N 142 
HHT C6  H2   sing N N 143 
HHT C8  H3   sing N N 144 
HHT C8  H4   sing N N 145 
HHT C3  H5   sing N N 146 
HHT C1  H6   sing N N 147 
HHT C1  H7   sing N N 148 
HHT C1  H8   sing N N 149 
HHT O2  H9   sing N N 150 
HIS N   CA   sing N N 151 
HIS N   H    sing N N 152 
HIS N   H2   sing N N 153 
HIS CA  C    sing N N 154 
HIS CA  CB   sing N N 155 
HIS CA  HA   sing N N 156 
HIS C   O    doub N N 157 
HIS C   OXT  sing N N 158 
HIS CB  CG   sing N N 159 
HIS CB  HB2  sing N N 160 
HIS CB  HB3  sing N N 161 
HIS CG  ND1  sing Y N 162 
HIS CG  CD2  doub Y N 163 
HIS ND1 CE1  doub Y N 164 
HIS ND1 HD1  sing N N 165 
HIS CD2 NE2  sing Y N 166 
HIS CD2 HD2  sing N N 167 
HIS CE1 NE2  sing Y N 168 
HIS CE1 HE1  sing N N 169 
HIS NE2 HE2  sing N N 170 
HIS OXT HXT  sing N N 171 
HOH O   H1   sing N N 172 
HOH O   H2   sing N N 173 
ILE N   CA   sing N N 174 
ILE N   H    sing N N 175 
ILE N   H2   sing N N 176 
ILE CA  C    sing N N 177 
ILE CA  CB   sing N N 178 
ILE CA  HA   sing N N 179 
ILE C   O    doub N N 180 
ILE C   OXT  sing N N 181 
ILE CB  CG1  sing N N 182 
ILE CB  CG2  sing N N 183 
ILE CB  HB   sing N N 184 
ILE CG1 CD1  sing N N 185 
ILE CG1 HG12 sing N N 186 
ILE CG1 HG13 sing N N 187 
ILE CG2 HG21 sing N N 188 
ILE CG2 HG22 sing N N 189 
ILE CG2 HG23 sing N N 190 
ILE CD1 HD11 sing N N 191 
ILE CD1 HD12 sing N N 192 
ILE CD1 HD13 sing N N 193 
ILE OXT HXT  sing N N 194 
LEU N   CA   sing N N 195 
LEU N   H    sing N N 196 
LEU N   H2   sing N N 197 
LEU CA  C    sing N N 198 
LEU CA  CB   sing N N 199 
LEU CA  HA   sing N N 200 
LEU C   O    doub N N 201 
LEU C   OXT  sing N N 202 
LEU CB  CG   sing N N 203 
LEU CB  HB2  sing N N 204 
LEU CB  HB3  sing N N 205 
LEU CG  CD1  sing N N 206 
LEU CG  CD2  sing N N 207 
LEU CG  HG   sing N N 208 
LEU CD1 HD11 sing N N 209 
LEU CD1 HD12 sing N N 210 
LEU CD1 HD13 sing N N 211 
LEU CD2 HD21 sing N N 212 
LEU CD2 HD22 sing N N 213 
LEU CD2 HD23 sing N N 214 
LEU OXT HXT  sing N N 215 
LYS N   CA   sing N N 216 
LYS N   H    sing N N 217 
LYS N   H2   sing N N 218 
LYS CA  C    sing N N 219 
LYS CA  CB   sing N N 220 
LYS CA  HA   sing N N 221 
LYS C   O    doub N N 222 
LYS C   OXT  sing N N 223 
LYS CB  CG   sing N N 224 
LYS CB  HB2  sing N N 225 
LYS CB  HB3  sing N N 226 
LYS CG  CD   sing N N 227 
LYS CG  HG2  sing N N 228 
LYS CG  HG3  sing N N 229 
LYS CD  CE   sing N N 230 
LYS CD  HD2  sing N N 231 
LYS CD  HD3  sing N N 232 
LYS CE  NZ   sing N N 233 
LYS CE  HE2  sing N N 234 
LYS CE  HE3  sing N N 235 
LYS NZ  HZ1  sing N N 236 
LYS NZ  HZ2  sing N N 237 
LYS NZ  HZ3  sing N N 238 
LYS OXT HXT  sing N N 239 
MET N   CA   sing N N 240 
MET N   H    sing N N 241 
MET N   H2   sing N N 242 
MET CA  C    sing N N 243 
MET CA  CB   sing N N 244 
MET CA  HA   sing N N 245 
MET C   O    doub N N 246 
MET C   OXT  sing N N 247 
MET CB  CG   sing N N 248 
MET CB  HB2  sing N N 249 
MET CB  HB3  sing N N 250 
MET CG  SD   sing N N 251 
MET CG  HG2  sing N N 252 
MET CG  HG3  sing N N 253 
MET SD  CE   sing N N 254 
MET CE  HE1  sing N N 255 
MET CE  HE2  sing N N 256 
MET CE  HE3  sing N N 257 
MET OXT HXT  sing N N 258 
PHE N   CA   sing N N 259 
PHE N   H    sing N N 260 
PHE N   H2   sing N N 261 
PHE CA  C    sing N N 262 
PHE CA  CB   sing N N 263 
PHE CA  HA   sing N N 264 
PHE C   O    doub N N 265 
PHE C   OXT  sing N N 266 
PHE CB  CG   sing N N 267 
PHE CB  HB2  sing N N 268 
PHE CB  HB3  sing N N 269 
PHE CG  CD1  doub Y N 270 
PHE CG  CD2  sing Y N 271 
PHE CD1 CE1  sing Y N 272 
PHE CD1 HD1  sing N N 273 
PHE CD2 CE2  doub Y N 274 
PHE CD2 HD2  sing N N 275 
PHE CE1 CZ   doub Y N 276 
PHE CE1 HE1  sing N N 277 
PHE CE2 CZ   sing Y N 278 
PHE CE2 HE2  sing N N 279 
PHE CZ  HZ   sing N N 280 
PHE OXT HXT  sing N N 281 
PRO N   CA   sing N N 282 
PRO N   CD   sing N N 283 
PRO N   H    sing N N 284 
PRO CA  C    sing N N 285 
PRO CA  CB   sing N N 286 
PRO CA  HA   sing N N 287 
PRO C   O    doub N N 288 
PRO C   OXT  sing N N 289 
PRO CB  CG   sing N N 290 
PRO CB  HB2  sing N N 291 
PRO CB  HB3  sing N N 292 
PRO CG  CD   sing N N 293 
PRO CG  HG2  sing N N 294 
PRO CG  HG3  sing N N 295 
PRO CD  HD2  sing N N 296 
PRO CD  HD3  sing N N 297 
PRO OXT HXT  sing N N 298 
SER N   CA   sing N N 299 
SER N   H    sing N N 300 
SER N   H2   sing N N 301 
SER CA  C    sing N N 302 
SER CA  CB   sing N N 303 
SER CA  HA   sing N N 304 
SER C   O    doub N N 305 
SER C   OXT  sing N N 306 
SER CB  OG   sing N N 307 
SER CB  HB2  sing N N 308 
SER CB  HB3  sing N N 309 
SER OG  HG   sing N N 310 
SER OXT HXT  sing N N 311 
THR N   CA   sing N N 312 
THR N   H    sing N N 313 
THR N   H2   sing N N 314 
THR CA  C    sing N N 315 
THR CA  CB   sing N N 316 
THR CA  HA   sing N N 317 
THR C   O    doub N N 318 
THR C   OXT  sing N N 319 
THR CB  OG1  sing N N 320 
THR CB  CG2  sing N N 321 
THR CB  HB   sing N N 322 
THR OG1 HG1  sing N N 323 
THR CG2 HG21 sing N N 324 
THR CG2 HG22 sing N N 325 
THR CG2 HG23 sing N N 326 
THR OXT HXT  sing N N 327 
TPO N   CA   sing N N 328 
TPO N   H    sing N N 329 
TPO N   H2   sing N N 330 
TPO CA  CB   sing N N 331 
TPO CA  C    sing N N 332 
TPO CA  HA   sing N N 333 
TPO CB  CG2  sing N N 334 
TPO CB  OG1  sing N N 335 
TPO CB  HB   sing N N 336 
TPO CG2 HG21 sing N N 337 
TPO CG2 HG22 sing N N 338 
TPO CG2 HG23 sing N N 339 
TPO OG1 P    sing N N 340 
TPO P   O1P  doub N N 341 
TPO P   O2P  sing N N 342 
TPO P   O3P  sing N N 343 
TPO O2P HOP2 sing N N 344 
TPO O3P HOP3 sing N N 345 
TPO C   O    doub N N 346 
TPO C   OXT  sing N N 347 
TPO OXT HXT  sing N N 348 
TRP N   CA   sing N N 349 
TRP N   H    sing N N 350 
TRP N   H2   sing N N 351 
TRP CA  C    sing N N 352 
TRP CA  CB   sing N N 353 
TRP CA  HA   sing N N 354 
TRP C   O    doub N N 355 
TRP C   OXT  sing N N 356 
TRP CB  CG   sing N N 357 
TRP CB  HB2  sing N N 358 
TRP CB  HB3  sing N N 359 
TRP CG  CD1  doub Y N 360 
TRP CG  CD2  sing Y N 361 
TRP CD1 NE1  sing Y N 362 
TRP CD1 HD1  sing N N 363 
TRP CD2 CE2  doub Y N 364 
TRP CD2 CE3  sing Y N 365 
TRP NE1 CE2  sing Y N 366 
TRP NE1 HE1  sing N N 367 
TRP CE2 CZ2  sing Y N 368 
TRP CE3 CZ3  doub Y N 369 
TRP CE3 HE3  sing N N 370 
TRP CZ2 CH2  doub Y N 371 
TRP CZ2 HZ2  sing N N 372 
TRP CZ3 CH2  sing Y N 373 
TRP CZ3 HZ3  sing N N 374 
TRP CH2 HH2  sing N N 375 
TRP OXT HXT  sing N N 376 
TYR N   CA   sing N N 377 
TYR N   H    sing N N 378 
TYR N   H2   sing N N 379 
TYR CA  C    sing N N 380 
TYR CA  CB   sing N N 381 
TYR CA  HA   sing N N 382 
TYR C   O    doub N N 383 
TYR C   OXT  sing N N 384 
TYR CB  CG   sing N N 385 
TYR CB  HB2  sing N N 386 
TYR CB  HB3  sing N N 387 
TYR CG  CD1  doub Y N 388 
TYR CG  CD2  sing Y N 389 
TYR CD1 CE1  sing Y N 390 
TYR CD1 HD1  sing N N 391 
TYR CD2 CE2  doub Y N 392 
TYR CD2 HD2  sing N N 393 
TYR CE1 CZ   doub Y N 394 
TYR CE1 HE1  sing N N 395 
TYR CE2 CZ   sing Y N 396 
TYR CE2 HE2  sing N N 397 
TYR CZ  OH   sing N N 398 
TYR OH  HH   sing N N 399 
TYR OXT HXT  sing N N 400 
VAL N   CA   sing N N 401 
VAL N   H    sing N N 402 
VAL N   H2   sing N N 403 
VAL CA  C    sing N N 404 
VAL CA  CB   sing N N 405 
VAL CA  HA   sing N N 406 
VAL C   O    doub N N 407 
VAL C   OXT  sing N N 408 
VAL CB  CG1  sing N N 409 
VAL CB  CG2  sing N N 410 
VAL CB  HB   sing N N 411 
VAL CG1 HG11 sing N N 412 
VAL CG1 HG12 sing N N 413 
VAL CG1 HG13 sing N N 414 
VAL CG2 HG21 sing N N 415 
VAL CG2 HG22 sing N N 416 
VAL CG2 HG23 sing N N 417 
VAL OXT HXT  sing N N 418 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Medical Research Council (MRC, United Kingdom)' 'United Kingdom' MR/N009738/1 1 
'Medical Research Council (MRC, United Kingdom)' 'United Kingdom' MR/V029142/1 2 
'Cancer Research UK'                             'United Kingdom' C2115/A21421 3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6GUC 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9ESJ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013511 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007454 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006772 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
BR 35 35 17.1822 2.1723  5.2368 16.5796 5.6388 0.2609  3.9859 41.4328 -0.0527  
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
P  15 15 6.4348  1.9067  4.1793 27.1570 1.7801 0.5260  1.4909 68.1645 1.2466   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0257   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLY A 1 1   ? -22.075 -6.441  24.822  1    90.67  ? -3  GLY A N   1 
ATOM   2    C  CA  . GLY A 1 1   ? -20.912 -7.053  25.492  1    100.54 ? -3  GLY A CA  1 
ATOM   3    C  C   . GLY A 1 1   ? -21.135 -7.212  26.991  1    125.65 ? -3  GLY A C   1 
ATOM   4    O  O   . GLY A 1 1   ? -20.349 -6.667  27.77   1    139.55 ? -3  GLY A O   1 
ATOM   5    N  N   . PRO A 1 2   ? -22.143 -8.021  27.427  1    142.88 ? -2  PRO A N   1 
ATOM   6    C  CA  . PRO A 1 2   ? -22.474 -8.203  28.849  1    129.71 ? -2  PRO A CA  1 
ATOM   7    C  C   . PRO A 1 2   ? -21.275 -8.556  29.725  1    110.81 ? -2  PRO A C   1 
ATOM   8    O  O   . PRO A 1 2   ? -21.321 -8.435  30.945  1    113.97 ? -2  PRO A O   1 
ATOM   9    C  CB  . PRO A 1 2   ? -23.51  -9.357  28.823  1    155.17 ? -2  PRO A CB  1 
ATOM   10   C  CG  . PRO A 1 2   ? -23.285 -10.067 27.499  1    139.68 ? -2  PRO A CG  1 
ATOM   11   C  CD  . PRO A 1 2   ? -22.951 -8.909  26.567  1    132.96 ? -2  PRO A CD  1 
ATOM   12   N  N   . GLY A 1 3   ? -20.205 -9.006  29.067  1    107.57 ? -1  GLY A N   1 
ATOM   13   C  CA  . GLY A 1 3   ? -18.894 -9.189  29.672  1    102.52 ? -1  GLY A CA  1 
ATOM   14   C  C   . GLY A 1 3   ? -18.359 -7.939  30.381  1    108.41 ? -1  GLY A C   1 
ATOM   15   O  O   . GLY A 1 3   ? -18.594 -6.801  29.974  1    105.43 ? -1  GLY A O   1 
ATOM   16   N  N   . SER A 1 4   ? -17.653 -8.194  31.483  1    109.79 ? 0   SER A N   1 
ATOM   17   C  CA  . SER A 1 4   ? -16.878 -7.226  32.247  1    110.57 ? 0   SER A CA  1 
ATOM   18   C  C   . SER A 1 4   ? -15.847 -7.994  33.079  1    106.65 ? 0   SER A C   1 
ATOM   19   O  O   . SER A 1 4   ? -16.227 -8.836  33.893  1    99.85  ? 0   SER A O   1 
ATOM   20   C  CB  . SER A 1 4   ? -17.773 -6.319  33.1    1    115.54 ? 0   SER A CB  1 
ATOM   21   O  OG  . SER A 1 4   ? -17.107 -5.791  34.245  1    108.39 ? 0   SER A OG  1 
ATOM   22   N  N   . MET A 1 5   ? -14.558 -7.684  32.86   1    98.53  ? 1   MET A N   1 
ATOM   23   C  CA  . MET A 1 5   ? -13.394 -8.399  33.376  1    90.28  ? 1   MET A CA  1 
ATOM   24   C  C   . MET A 1 5   ? -13.508 -8.769  34.855  1    86.56  ? 1   MET A C   1 
ATOM   25   O  O   . MET A 1 5   ? -13.088 -9.856  35.249  1    91.01  ? 1   MET A O   1 
ATOM   26   C  CB  . MET A 1 5   ? -12.131 -7.561  33.192  1    90.87  ? 1   MET A CB  1 
ATOM   27   C  CG  . MET A 1 5   ? -11.759 -7.396  31.74   1    89.02  ? 1   MET A CG  1 
ATOM   28   S  SD  . MET A 1 5   ? -11.467 -8.972  30.915  1    89.47  ? 1   MET A SD  1 
ATOM   29   C  CE  . MET A 1 5   ? -13.109 -9.393  30.34   1    77.76  ? 1   MET A CE  1 
ATOM   30   N  N   . GLU A 1 6   ? -14.096 -7.879  35.652  1    82.08  ? 2   GLU A N   1 
ATOM   31   C  CA  . GLU A 1 6   ? -14.251 -8.068  37.088  1    86.31  ? 2   GLU A CA  1 
ATOM   32   C  C   . GLU A 1 6   ? -14.83  -9.442  37.443  1    80.48  ? 2   GLU A C   1 
ATOM   33   O  O   . GLU A 1 6   ? -14.383 -10.052 38.415  1    82.53  ? 2   GLU A O   1 
ATOM   34   C  CB  . GLU A 1 6   ? -15.067 -6.918  37.682  1    94.23  ? 2   GLU A CB  1 
ATOM   35   C  CG  . GLU A 1 6   ? -15.434 -7.12   39.148  1    107.06 ? 2   GLU A CG  1 
ATOM   36   C  CD  . GLU A 1 6   ? -14.253 -7.447  40.058  1    112.05 ? 2   GLU A CD  1 
ATOM   37   O  OE1 . GLU A 1 6   ? -14.412 -8.286  40.981  1    109.46 ? 2   GLU A OE1 1 
ATOM   38   O  OE2 . GLU A 1 6   ? -13.153 -6.901  39.807  1    111.33 ? 2   GLU A OE2 1 
ATOM   39   N  N   . ASN A 1 7   ? -15.794 -9.937  36.645  1    73.48  ? 3   ASN A N   1 
ATOM   40   C  CA  . ASN A 1 7   ? -16.432 -11.217 36.924  1    69.46  ? 3   ASN A CA  1 
ATOM   41   C  C   . ASN A 1 7   ? -15.591 -12.413 36.511  1    66.53  ? 3   ASN A C   1 
ATOM   42   O  O   . ASN A 1 7   ? -16.052 -13.537 36.68   1    70.05  ? 3   ASN A O   1 
ATOM   43   C  CB  . ASN A 1 7   ? -17.756 -11.437 36.206  1    70.5   ? 3   ASN A CB  1 
ATOM   44   C  CG  . ASN A 1 7   ? -18.79  -10.43  36.629  1    77.86  ? 3   ASN A CG  1 
ATOM   45   O  OD1 . ASN A 1 7   ? -18.797 -9.963  37.783  1    84.98  ? 3   ASN A OD1 1 
ATOM   46   N  ND2 . ASN A 1 7   ? -19.606 -10.049 35.659  1    79     ? 3   ASN A ND2 1 
ATOM   47   N  N   . PHE A 1 8   ? -14.393 -12.206 35.952  1    62.33  ? 4   PHE A N   1 
ATOM   48   C  CA  . PHE A 1 8   ? -13.571 -13.35  35.595  1    58.95  ? 4   PHE A CA  1 
ATOM   49   C  C   . PHE A 1 8   ? -12.43  -13.543 36.594  1    63.08  ? 4   PHE A C   1 
ATOM   50   O  O   . PHE A 1 8   ? -11.829 -12.587 37.086  1    68.4   ? 4   PHE A O   1 
ATOM   51   C  CB  . PHE A 1 8   ? -13.077 -13.204 34.172  1    55.91  ? 4   PHE A CB  1 
ATOM   52   C  CG  . PHE A 1 8   ? -14.164 -13.343 33.132  1    55.33  ? 4   PHE A CG  1 
ATOM   53   C  CD1 . PHE A 1 8   ? -14.778 -14.579 32.911  1    55.84  ? 4   PHE A CD1 1 
ATOM   54   C  CD2 . PHE A 1 8   ? -14.55  -12.257 32.352  1    55.91  ? 4   PHE A CD2 1 
ATOM   55   C  CE1 . PHE A 1 8   ? -15.758 -14.722 31.925  1    53.98  ? 4   PHE A CE1 1 
ATOM   56   C  CE2 . PHE A 1 8   ? -15.517 -12.41  31.364  1    57.67  ? 4   PHE A CE2 1 
ATOM   57   C  CZ  . PHE A 1 8   ? -16.11  -13.643 31.134  1    54.29  ? 4   PHE A CZ  1 
ATOM   58   N  N   . GLN A 1 9   ? -12.178 -14.806 36.937  1    62.74  ? 5   GLN A N   1 
ATOM   59   C  CA  . GLN A 1 9   ? -11.061 -15.175 37.782  1    65.14  ? 5   GLN A CA  1 
ATOM   60   C  C   . GLN A 1 9   ? -10.068 -15.945 36.924  1    64.01  ? 5   GLN A C   1 
ATOM   61   O  O   . GLN A 1 9   ? -10.418 -16.973 36.357  1    61.37  ? 5   GLN A O   1 
ATOM   62   C  CB  . GLN A 1 9   ? -11.533 -15.983 38.989  1    69.12  ? 5   GLN A CB  1 
ATOM   63   C  CG  . GLN A 1 9   ? -10.44  -16.192 40.028  1    81.4   ? 5   GLN A CG  1 
ATOM   64   C  CD  . GLN A 1 9   ? -9.755  -14.895 40.422  1    95.59  ? 5   GLN A CD  1 
ATOM   65   O  OE1 . GLN A 1 9   ? -10.387 -13.91  40.839  1    104.78 ? 5   GLN A OE1 1 
ATOM   66   N  NE2 . GLN A 1 9   ? -8.436  -14.875 40.28   1    101.02 ? 5   GLN A NE2 1 
ATOM   67   N  N   . LYS A 1 10  ? -8.834  -15.435 36.832  1    66.46  ? 6   LYS A N   1 
ATOM   68   C  CA  . LYS A 1 10  ? -7.767  -16.086 36.081  1    68.47  ? 6   LYS A CA  1 
ATOM   69   C  C   . LYS A 1 10  ? -7.459  -17.452 36.685  1    68.45  ? 6   LYS A C   1 
ATOM   70   O  O   . LYS A 1 10  ? -7.532  -17.587 37.902  1    72.12  ? 6   LYS A O   1 
ATOM   71   C  CB  . LYS A 1 10  ? -6.514  -15.215 36.214  1    74.28  ? 6   LYS A CB  1 
ATOM   72   C  CG  . LYS A 1 10  ? -5.295  -15.637 35.393  1    78.38  ? 6   LYS A CG  1 
ATOM   73   C  CD  . LYS A 1 10  ? -4.005  -14.915 35.782  1    85.86  ? 6   LYS A CD  1 
ATOM   74   C  CE  . LYS A 1 10  ? -3.628  -15.133 37.249  1    84.97  ? 6   LYS A CE  1 
ATOM   75   N  NZ  . LYS A 1 10  ? -3.027  -13.971 37.909  1    86.12  ? 6   LYS A NZ  1 
ATOM   76   N  N   . VAL A 1 11  ? -7.073  -18.423 35.841  1    69.06  ? 7   VAL A N   1 
ATOM   77   C  CA  . VAL A 1 11  ? -6.685  -19.764 36.276  1    70.6   ? 7   VAL A CA  1 
ATOM   78   C  C   . VAL A 1 11  ? -5.226  -20.038 35.895  1    72.36  ? 7   VAL A C   1 
ATOM   79   O  O   . VAL A 1 11  ? -4.409  -20.247 36.788  1    81.13  ? 7   VAL A O   1 
ATOM   80   C  CB  . VAL A 1 11  ? -7.627  -20.866 35.757  1    64.67  ? 7   VAL A CB  1 
ATOM   81   C  CG1 . VAL A 1 11  ? -7.284  -22.223 36.339  1    63.07  ? 7   VAL A CG1 1 
ATOM   82   C  CG2 . VAL A 1 11  ? -9.077  -20.542 36.054  1    62.59  ? 7   VAL A CG2 1 
ATOM   83   N  N   . GLU A 1 12  ? -4.902  -20.018 34.589  1    65.91  ? 8   GLU A N   1 
ATOM   84   C  CA  . GLU A 1 12  ? -3.533  -20.186 34.124  1    68.23  ? 8   GLU A CA  1 
ATOM   85   C  C   . GLU A 1 12  ? -3.41   -19.814 32.647  1    71.02  ? 8   GLU A C   1 
ATOM   86   O  O   . GLU A 1 12  ? -4.405  -19.872 31.911  1    70.31  ? 8   GLU A O   1 
ATOM   87   C  CB  . GLU A 1 12  ? -3.084  -21.634 34.292  1    70.2   ? 8   GLU A CB  1 
ATOM   88   C  CG  . GLU A 1 12  ? -3.61   -22.574 33.215  1    68.77  ? 8   GLU A CG  1 
ATOM   89   C  CD  . GLU A 1 12  ? -3.736  -24.037 33.594  1    72.39  ? 8   GLU A CD  1 
ATOM   90   O  OE1 . GLU A 1 12  ? -3.569  -24.392 34.773  1    78.34  ? 8   GLU A OE1 1 
ATOM   91   O  OE2 . GLU A 1 12  ? -4.02   -24.836 32.686  1    71.04  ? 8   GLU A OE2 1 
ATOM   92   N  N   . LYS A 1 13  ? -2.187  -19.431 32.219  1    69.96  ? 9   LYS A N   1 
ATOM   93   C  CA  . LYS A 1 13  ? -1.924  -19.131 30.819  1    68.36  ? 9   LYS A CA  1 
ATOM   94   C  C   . LYS A 1 13  ? -2.145  -20.42  30.034  1    65.2   ? 9   LYS A C   1 
ATOM   95   O  O   . LYS A 1 13  ? -1.889  -21.495 30.553  1    70.1   ? 9   LYS A O   1 
ATOM   96   C  CB  . LYS A 1 13  ? -0.502  -18.585 30.637  1    72.9   ? 9   LYS A CB  1 
ATOM   97   C  CG  . LYS A 1 13  ? -0.155  -18.216 29.191  1    78.59  ? 9   LYS A CG  1 
ATOM   98   C  CD  . LYS A 1 13  ? 1.332   -17.985 28.911  1    86.81  ? 9   LYS A CD  1 
ATOM   99   C  CE  . LYS A 1 13  ? 1.58    -17.247 27.603  1    97.61  ? 9   LYS A CE  1 
ATOM   100  N  NZ  . LYS A 1 13  ? 2.578   -17.84  26.707  1    100.95 ? 9   LYS A NZ  1 
ATOM   101  N  N   . ILE A 1 14  ? -2.637  -20.336 28.801  1    60.57  ? 10  ILE A N   1 
ATOM   102  C  CA  . ILE A 1 14  ? -2.859  -21.555 28.045  1    60.58  ? 10  ILE A CA  1 
ATOM   103  C  C   . ILE A 1 14  ? -2.282  -21.424 26.642  1    61.82  ? 10  ILE A C   1 
ATOM   104  O  O   . ILE A 1 14  ? -2.318  -22.375 25.86   1    67.85  ? 10  ILE A O   1 
ATOM   105  C  CB  . ILE A 1 14  ? -4.347  -21.971 28.038  1    62.42  ? 10  ILE A CB  1 
ATOM   106  C  CG1 . ILE A 1 14  ? -5.285  -20.844 27.557  1    61.98  ? 10  ILE A CG1 1 
ATOM   107  C  CG2 . ILE A 1 14  ? -4.759  -22.484 29.421  1    68.1   ? 10  ILE A CG2 1 
ATOM   108  C  CD1 . ILE A 1 14  ? -6.724  -21.273 27.335  1    54.61  ? 10  ILE A CD1 1 
ATOM   109  N  N   . GLY A 1 15  ? -1.767  -20.241 26.312  1    66.27  ? 11  GLY A N   1 
ATOM   110  C  CA  . GLY A 1 15  ? -1.37   -19.997 24.931  1    72.51  ? 11  GLY A CA  1 
ATOM   111  C  C   . GLY A 1 15  ? -1.032  -18.533 24.678  1    81.96  ? 11  GLY A C   1 
ATOM   112  O  O   . GLY A 1 15  ? -1.509  -17.65  25.391  1    81.63  ? 11  GLY A O   1 
ATOM   113  N  N   . GLU A 1 16  ? -0.232  -18.313 23.63   1    96.87  ? 12  GLU A N   1 
ATOM   114  C  CA  . GLU A 1 16  ? 0.161   -16.988 23.177  1    107    ? 12  GLU A CA  1 
ATOM   115  C  C   . GLU A 1 16  ? 0.26    -16.961 21.647  1    114.75 ? 12  GLU A C   1 
ATOM   116  O  O   . GLU A 1 16  ? 1.03    -17.724 21.073  1    108.26 ? 12  GLU A O   1 
ATOM   117  C  CB  . GLU A 1 16  ? 1.468   -16.601 23.876  1    103.18 ? 12  GLU A CB  1 
ATOM   118  C  CG  . GLU A 1 16  ? 2.2     -15.449 23.193  1    109.1  ? 12  GLU A CG  1 
ATOM   119  C  CD  . GLU A 1 16  ? 2.896   -14.512 24.17   1    121.07 ? 12  GLU A CD  1 
ATOM   120  O  OE1 . GLU A 1 16  ? 2.501   -13.316 24.284  1    129.15 ? 12  GLU A OE1 1 
ATOM   121  O  OE2 . GLU A 1 16  ? 3.854   -14.995 24.812  1    115.59 ? 12  GLU A OE2 1 
ATOM   122  N  N   . GLY A 1 17  ? -0.522  -16.079 20.996  1    123.08 ? 13  GLY A N   1 
ATOM   123  C  CA  . GLY A 1 17  ? -0.337  -15.703 19.595  1    112.2  ? 13  GLY A CA  1 
ATOM   124  C  C   . GLY A 1 17  ? 0.572   -14.471 19.432  1    116.11 ? 13  GLY A C   1 
ATOM   125  O  O   . GLY A 1 17  ? 1.135   -13.952 20.403  1    103.61 ? 13  GLY A O   1 
ATOM   126  N  N   . THR A 1 18  ? 0.709   -13.975 18.191  1    111.06 ? 14  THR A N   1 
ATOM   127  C  CA  . THR A 1 18  ? 1.416   -12.723 17.937  1    111.42 ? 14  THR A CA  1 
ATOM   128  C  C   . THR A 1 18  ? 0.721   -11.597 18.694  1    123.22 ? 14  THR A C   1 
ATOM   129  O  O   . THR A 1 18  ? 1.379   -10.794 19.354  1    116.04 ? 14  THR A O   1 
ATOM   130  C  CB  . THR A 1 18  ? 1.446   -12.366 16.447  1    114.22 ? 14  THR A CB  1 
ATOM   131  O  OG1 . THR A 1 18  ? 2.484   -13.133 15.847  1    114.6  ? 14  THR A OG1 1 
ATOM   132  C  CG2 . THR A 1 18  ? 1.741   -10.894 16.195  1    105.21 ? 14  THR A CG2 1 
ATOM   133  N  N   . TYR A 1 19  ? -0.611  -11.538 18.553  1    126.76 ? 15  TYR A N   1 
ATOM   134  C  CA  . TYR A 1 19  ? -1.377  -10.438 19.112  1    127.72 ? 15  TYR A CA  1 
ATOM   135  C  C   . TYR A 1 19  ? -1.97   -10.86  20.454  1    126.31 ? 15  TYR A C   1 
ATOM   136  O  O   . TYR A 1 19  ? -3.152  -10.64  20.714  1    139.47 ? 15  TYR A O   1 
ATOM   137  C  CB  . TYR A 1 19  ? -2.406  -9.885  18.123  1    128.77 ? 15  TYR A CB  1 
ATOM   138  C  CG  . TYR A 1 19  ? -1.911  -9.561  16.718  1    132.49 ? 15  TYR A CG  1 
ATOM   139  C  CD1 . TYR A 1 19  ? -1.763  -10.575 15.769  1    140.29 ? 15  TYR A CD1 1 
ATOM   140  C  CD2 . TYR A 1 19  ? -1.642  -8.248  16.317  1    121.56 ? 15  TYR A CD2 1 
ATOM   141  C  CE1 . TYR A 1 19  ? -1.343  -10.3   14.474  1    129.97 ? 15  TYR A CE1 1 
ATOM   142  C  CE2 . TYR A 1 19  ? -1.23   -7.959  15.02   1    117.68 ? 15  TYR A CE2 1 
ATOM   143  C  CZ  . TYR A 1 19  ? -1.074  -8.992  14.101  1    127.58 ? 15  TYR A CZ  1 
ATOM   144  O  OH  . TYR A 1 19  ? -0.677  -8.795  12.81   1    125.19 ? 15  TYR A OH  1 
ATOM   145  N  N   . GLY A 1 20  ? -1.135  -11.478 21.301  1    121.6  ? 16  GLY A N   1 
ATOM   146  C  CA  . GLY A 1 20  ? -1.348  -11.466 22.74   1    106.91 ? 16  GLY A CA  1 
ATOM   147  C  C   . GLY A 1 20  ? -1.212  -12.833 23.403  1    96.85  ? 16  GLY A C   1 
ATOM   148  O  O   . GLY A 1 20  ? -0.39   -13.663 23.023  1    114.66 ? 16  GLY A O   1 
ATOM   149  N  N   . VAL A 1 21  ? -2.039  -13.04  24.43   1    88.87  ? 17  VAL A N   1 
ATOM   150  C  CA  . VAL A 1 21  ? -1.975  -14.244 25.247  1    83.02  ? 17  VAL A CA  1 
ATOM   151  C  C   . VAL A 1 21  ? -3.393  -14.802 25.434  1    74.25  ? 17  VAL A C   1 
ATOM   152  O  O   . VAL A 1 21  ? -4.372  -14.071 25.337  1    77.1   ? 17  VAL A O   1 
ATOM   153  C  CB  . VAL A 1 21  ? -1.321  -13.884 26.598  1    81.57  ? 17  VAL A CB  1 
ATOM   154  C  CG1 . VAL A 1 21  ? -2.054  -12.766 27.337  1    77.64  ? 17  VAL A CG1 1 
ATOM   155  C  CG2 . VAL A 1 21  ? -1.183  -15.103 27.499  1    84.45  ? 17  VAL A CG2 1 
ATOM   156  N  N   . VAL A 1 22  ? -3.506  -16.094 25.727  1    61.59  ? 18  VAL A N   1 
ATOM   157  C  CA  . VAL A 1 22  ? -4.789  -16.661 26.088  1    55.37  ? 18  VAL A CA  1 
ATOM   158  C  C   . VAL A 1 22  ? -4.672  -17.235 27.493  1    60.23  ? 18  VAL A C   1 
ATOM   159  O  O   . VAL A 1 22  ? -3.675  -17.887 27.812  1    68.01  ? 18  VAL A O   1 
ATOM   160  C  CB  . VAL A 1 22  ? -5.234  -17.721 25.068  1    50.35  ? 18  VAL A CB  1 
ATOM   161  C  CG1 . VAL A 1 22  ? -6.67   -18.161 25.319  1    51.49  ? 18  VAL A CG1 1 
ATOM   162  C  CG2 . VAL A 1 22  ? -5.116  -17.189 23.64   1    48.69  ? 18  VAL A CG2 1 
ATOM   163  N  N   . TYR A 1 23  ? -5.678  -16.954 28.338  1    59.03  ? 19  TYR A N   1 
ATOM   164  C  CA  . TYR A 1 23  ? -5.739  -17.471 29.694  1    59     ? 19  TYR A CA  1 
ATOM   165  C  C   . TYR A 1 23  ? -7.012  -18.284 29.893  1    55.85  ? 19  TYR A C   1 
ATOM   166  O  O   . TYR A 1 23  ? -8.086  -17.85  29.509  1    55.43  ? 19  TYR A O   1 
ATOM   167  C  CB  . TYR A 1 23  ? -5.715  -16.325 30.71   1    63.59  ? 19  TYR A CB  1 
ATOM   168  C  CG  . TYR A 1 23  ? -4.342  -15.788 31.106  1    71.76  ? 19  TYR A CG  1 
ATOM   169  C  CD1 . TYR A 1 23  ? -3.63   -14.941 30.257  1    73.71  ? 19  TYR A CD1 1 
ATOM   170  C  CD2 . TYR A 1 23  ? -3.765  -16.111 32.339  1    76.69  ? 19  TYR A CD2 1 
ATOM   171  C  CE1 . TYR A 1 23  ? -2.38   -14.451 30.602  1    81.5   ? 19  TYR A CE1 1 
ATOM   172  C  CE2 . TYR A 1 23  ? -2.513  -15.628 32.696  1    82.99  ? 19  TYR A CE2 1 
ATOM   173  C  CZ  . TYR A 1 23  ? -1.824  -14.798 31.827  1    89.42  ? 19  TYR A CZ  1 
ATOM   174  O  OH  . TYR A 1 23  ? -0.605  -14.311 32.204  1    99.12  ? 19  TYR A OH  1 
ATOM   175  N  N   . LYS A 1 24  ? -6.905  -19.449 30.534  1    54.87  ? 20  LYS A N   1 
ATOM   176  C  CA  . LYS A 1 24  ? -8.086  -20.094 31.088  1    53.05  ? 20  LYS A CA  1 
ATOM   177  C  C   . LYS A 1 24  ? -8.609  -19.237 32.243  1    56.25  ? 20  LYS A C   1 
ATOM   178  O  O   . LYS A 1 24  ? -7.851  -18.841 33.126  1    57.76  ? 20  LYS A O   1 
ATOM   179  C  CB  . LYS A 1 24  ? -7.741  -21.512 31.547  1    53.52  ? 20  LYS A CB  1 
ATOM   180  C  CG  . LYS A 1 24  ? -8.848  -22.308 32.214  1    53.97  ? 20  LYS A CG  1 
ATOM   181  C  CD  . LYS A 1 24  ? -8.38   -23.67  32.745  1    56.88  ? 20  LYS A CD  1 
ATOM   182  C  CE  . LYS A 1 24  ? -9.558  -24.543 33.097  1    56.71  ? 20  LYS A CE  1 
ATOM   183  N  NZ  . LYS A 1 24  ? -9.25   -25.906 33.512  1    57.21  ? 20  LYS A NZ  1 
ATOM   184  N  N   . ALA A 1 25  ? -9.912  -18.913 32.217  1    54.38  ? 21  ALA A N   1 
ATOM   185  C  CA  . ALA A 1 25  ? -10.505 -18.111 33.274  1    53.24  ? 21  ALA A CA  1 
ATOM   186  C  C   . ALA A 1 25  ? -11.87  -18.693 33.622  1    53.64  ? 21  ALA A C   1 
ATOM   187  O  O   . ALA A 1 25  ? -12.414 -19.515 32.882  1    53.54  ? 21  ALA A O   1 
ATOM   188  C  CB  . ALA A 1 25  ? -10.602 -16.667 32.851  1    50.7   ? 21  ALA A CB  1 
ATOM   189  N  N   . ARG A 1 26  ? -12.4   -18.252 34.757  1    53.29  ? 22  ARG A N   1 
ATOM   190  C  CA  . ARG A 1 26  ? -13.61  -18.789 35.322  1    54.98  ? 22  ARG A CA  1 
ATOM   191  C  C   . ARG A 1 26  ? -14.532 -17.61  35.631  1    55.21  ? 22  ARG A C   1 
ATOM   192  O  O   . ARG A 1 26  ? -14.138 -16.639 36.26   1    54.88  ? 22  ARG A O   1 
ATOM   193  C  CB  . ARG A 1 26  ? -13.21  -19.55  36.593  1    61.89  ? 22  ARG A CB  1 
ATOM   194  C  CG  . ARG A 1 26  ? -14.219 -20.588 37.058  1    69.68  ? 22  ARG A CG  1 
ATOM   195  C  CD  . ARG A 1 26  ? -13.756 -21.24  38.341  1    75.03  ? 22  ARG A CD  1 
ATOM   196  N  NE  . ARG A 1 26  ? -14.138 -20.333 39.434  1    89.55  ? 22  ARG A NE  1 
ATOM   197  C  CZ  . ARG A 1 26  ? -13.309 -19.642 40.222  1    97.55  ? 22  ARG A CZ  1 
ATOM   198  N  NH1 . ARG A 1 26  ? -12.002 -19.732 40.024  1    98.74  ? 22  ARG A NH1 1 
ATOM   199  N  NH2 . ARG A 1 26  ? -13.791 -18.858 41.178  1    90.2   ? 22  ARG A NH2 1 
ATOM   200  N  N   . ASN A 1 27  ? -15.773 -17.698 35.151  1    54.61  ? 23  ASN A N   1 
ATOM   201  C  CA  . ASN A 1 27  ? -16.792 -16.682 35.372  1    51.37  ? 23  ASN A CA  1 
ATOM   202  C  C   . ASN A 1 27  ? -17.275 -16.869 36.793  1    53.74  ? 23  ASN A C   1 
ATOM   203  O  O   . ASN A 1 27  ? -17.754 -17.935 37.142  1    55.17  ? 23  ASN A O   1 
ATOM   204  C  CB  . ASN A 1 27  ? -17.904 -16.857 34.339  1    47     ? 23  ASN A CB  1 
ATOM   205  C  CG  . ASN A 1 27  ? -19.03  -15.865 34.472  1    46.2   ? 23  ASN A CG  1 
ATOM   206  O  OD1 . ASN A 1 27  ? -19.485 -15.571 35.581  1    47.75  ? 23  ASN A OD1 1 
ATOM   207  N  ND2 . ASN A 1 27  ? -19.501 -15.368 33.333  1    44.52  ? 23  ASN A ND2 1 
ATOM   208  N  N   . LYS A 1 28  ? -17.094 -15.856 37.628  1    58.35  ? 24  LYS A N   1 
ATOM   209  C  CA  . LYS A 1 28  ? -17.345 -16.001 39.053  1    61.6   ? 24  LYS A CA  1 
ATOM   210  C  C   . LYS A 1 28  ? -18.842 -16.123 39.341  1    61.12  ? 24  LYS A C   1 
ATOM   211  O  O   . LYS A 1 28  ? -19.202 -16.614 40.401  1    61.85  ? 24  LYS A O   1 
ATOM   212  C  CB  . LYS A 1 28  ? -16.725 -14.843 39.838  1    66.49  ? 24  LYS A CB  1 
ATOM   213  C  CG  . LYS A 1 28  ? -15.306 -15.046 40.323  1    74.61  ? 24  LYS A CG  1 
ATOM   214  C  CD  . LYS A 1 28  ? -14.632 -13.828 40.969  1    82.03  ? 24  LYS A CD  1 
ATOM   215  C  CE  . LYS A 1 28  ? -13.987 -12.892 39.93   1    85.24  ? 24  LYS A CE  1 
ATOM   216  N  NZ  . LYS A 1 28  ? -13.557 -11.621 40.55   1    88.82  ? 24  LYS A NZ  1 
ATOM   217  N  N   . LEU A 1 29  ? -19.711 -15.723 38.401  1    60.86  ? 25  LEU A N   1 
ATOM   218  C  CA  . LEU A 1 29  ? -21.145 -15.683 38.683  1    63.08  ? 25  LEU A CA  1 
ATOM   219  C  C   . LEU A 1 29  ? -21.889 -16.897 38.125  1    61.23  ? 25  LEU A C   1 
ATOM   220  O  O   . LEU A 1 29  ? -22.824 -17.382 38.756  1    64.66  ? 25  LEU A O   1 
ATOM   221  C  CB  . LEU A 1 29  ? -21.753 -14.377 38.174  1    60.68  ? 25  LEU A CB  1 
ATOM   222  C  CG  . LEU A 1 29  ? -21.27  -13.117 38.898  1    61.18  ? 25  LEU A CG  1 
ATOM   223  C  CD1 . LEU A 1 29  ? -21.788 -11.908 38.155  1    61.77  ? 25  LEU A CD1 1 
ATOM   224  C  CD2 . LEU A 1 29  ? -21.72  -13.098 40.327  1    61.71  ? 25  LEU A CD2 1 
ATOM   225  N  N   . THR A 1 30  ? -21.483 -17.362 36.946  1    54.88  ? 26  THR A N   1 
ATOM   226  C  CA  . THR A 1 30  ? -22.137 -18.491 36.305  1    56.55  ? 26  THR A CA  1 
ATOM   227  C  C   . THR A 1 30  ? -21.4   -19.817 36.533  1    59.55  ? 26  THR A C   1 
ATOM   228  O  O   . THR A 1 30  ? -22.048 -20.872 36.487  1    58.93  ? 26  THR A O   1 
ATOM   229  C  CB  . THR A 1 30  ? -22.294 -18.249 34.805  1    51.39  ? 26  THR A CB  1 
ATOM   230  O  OG1 . THR A 1 30  ? -20.992 -18.103 34.243  1    48.67  ? 26  THR A OG1 1 
ATOM   231  C  CG2 . THR A 1 30  ? -23.183 -17.044 34.576  1    51.09  ? 26  THR A CG2 1 
ATOM   232  N  N   . GLY A 1 31  ? -20.061 -19.75  36.719  1    59.05  ? 27  GLY A N   1 
ATOM   233  C  CA  . GLY A 1 31  ? -19.184 -20.892 36.947  1    53.23  ? 27  GLY A CA  1 
ATOM   234  C  C   . GLY A 1 31  ? -18.478 -21.293 35.664  1    50.24  ? 27  GLY A C   1 
ATOM   235  O  O   . GLY A 1 31  ? -17.542 -22.089 35.684  1    52.46  ? 27  GLY A O   1 
ATOM   236  N  N   . GLU A 1 32  ? -18.917 -20.697 34.559  1    46.4   ? 28  GLU A N   1 
ATOM   237  C  CA  . GLU A 1 32  ? -18.434 -21.075 33.25   1    45.55  ? 28  GLU A CA  1 
ATOM   238  C  C   . GLU A 1 32  ? -16.919 -20.897 33.181  1    46.31  ? 28  GLU A C   1 
ATOM   239  O  O   . GLU A 1 32  ? -16.395 -19.87  33.584  1    47.82  ? 28  GLU A O   1 
ATOM   240  C  CB  . GLU A 1 32  ? -19.186 -20.278 32.178  1    43.24  ? 28  GLU A CB  1 
ATOM   241  C  CG  . GLU A 1 32  ? -18.824 -20.695 30.764  1    41.49  ? 28  GLU A CG  1 
ATOM   242  C  CD  . GLU A 1 32  ? -19.585 -19.978 29.682  1    43.22  ? 28  GLU A CD  1 
ATOM   243  O  OE1 . GLU A 1 32  ? -19.967 -18.832 29.871  1    46.91  ? 28  GLU A OE1 1 
ATOM   244  O  OE2 . GLU A 1 32  ? -19.723 -20.542 28.598  1    48.71  ? 28  GLU A OE2 1 
ATOM   245  N  N   . VAL A 1 33  ? -16.243 -21.895 32.605  1    46.41  ? 29  VAL A N   1 
ATOM   246  C  CA  . VAL A 1 33  ? -14.83  -21.839 32.281  1    46.08  ? 29  VAL A CA  1 
ATOM   247  C  C   . VAL A 1 33  ? -14.719 -21.335 30.854  1    48.05  ? 29  VAL A C   1 
ATOM   248  O  O   . VAL A 1 33  ? -15.434 -21.807 29.965  1    48.14  ? 29  VAL A O   1 
ATOM   249  C  CB  . VAL A 1 33  ? -14.157 -23.209 32.485  1    46.14  ? 29  VAL A CB  1 
ATOM   250  C  CG1 . VAL A 1 33  ? -12.665 -23.167 32.232  1    48.21  ? 29  VAL A CG1 1 
ATOM   251  C  CG2 . VAL A 1 33  ? -14.328 -23.704 33.918  1    49.24  ? 29  VAL A CG2 1 
ATOM   252  N  N   . VAL A 1 34  ? -13.858 -20.327 30.665  1    48.17  ? 30  VAL A N   1 
ATOM   253  C  CA  . VAL A 1 34  ? -13.713 -19.659 29.384  1    45.22  ? 30  VAL A CA  1 
ATOM   254  C  C   . VAL A 1 34  ? -12.233 -19.545 29.045  1    46.34  ? 30  VAL A C   1 
ATOM   255  O  O   . VAL A 1 34  ? -11.37  -19.714 29.897  1    48.44  ? 30  VAL A O   1 
ATOM   256  C  CB  . VAL A 1 34  ? -14.35  -18.26  29.44   1    44.88  ? 30  VAL A CB  1 
ATOM   257  C  CG1 . VAL A 1 34  ? -15.836 -18.35  29.725  1    43.13  ? 30  VAL A CG1 1 
ATOM   258  C  CG2 . VAL A 1 34  ? -13.67  -17.338 30.45   1    43.53  ? 30  VAL A CG2 1 
ATOM   259  N  N   . ALA A 1 35  ? -11.957 -19.24  27.783  1    45.05  ? 31  ALA A N   1 
ATOM   260  C  CA  . ALA A 1 35  ? -10.633 -18.83  27.376  1    46.02  ? 31  ALA A CA  1 
ATOM   261  C  C   . ALA A 1 35  ? -10.698 -17.342 27.028  1    46.37  ? 31  ALA A C   1 
ATOM   262  O  O   . ALA A 1 35  ? -11.472 -16.964 26.15   1    46.99  ? 31  ALA A O   1 
ATOM   263  C  CB  . ALA A 1 35  ? -10.172 -19.692 26.21   1    40.53  ? 31  ALA A CB  1 
ATOM   264  N  N   . LEU A 1 36  ? -9.928  -16.508 27.746  1    47.76  ? 32  LEU A N   1 
ATOM   265  C  CA  . LEU A 1 36  ? -9.82   -15.083 27.449  1    49.36  ? 32  LEU A CA  1 
ATOM   266  C  C   . LEU A 1 36  ? -8.639  -14.804 26.528  1    47.83  ? 32  LEU A C   1 
ATOM   267  O  O   . LEU A 1 36  ? -7.526  -15.091 26.894  1    52.16  ? 32  LEU A O   1 
ATOM   268  C  CB  . LEU A 1 36  ? -9.643  -14.347 28.768  1    50.55  ? 32  LEU A CB  1 
ATOM   269  C  CG  . LEU A 1 36  ? -10.885 -14.247 29.646  1    54.19  ? 32  LEU A CG  1 
ATOM   270  C  CD1 . LEU A 1 36  ? -10.601 -13.412 30.874  1    53.83  ? 32  LEU A CD1 1 
ATOM   271  C  CD2 . LEU A 1 36  ? -12.025 -13.596 28.89   1    56.43  ? 32  LEU A CD2 1 
ATOM   272  N  N   . LYS A 1 37  ? -8.874  -14.272 25.336  1    47.48  ? 33  LYS A N   1 
ATOM   273  C  CA  . LYS A 1 37  ? -7.792  -13.83  24.47   1    50.47  ? 33  LYS A CA  1 
ATOM   274  C  C   . LYS A 1 37  ? -7.684  -12.314 24.629  1    55.03  ? 33  LYS A C   1 
ATOM   275  O  O   . LYS A 1 37  ? -8.667  -11.604 24.438  1    58     ? 33  LYS A O   1 
ATOM   276  C  CB  . LYS A 1 37  ? -8.042  -14.247 23.013  1    50.95  ? 33  LYS A CB  1 
ATOM   277  C  CG  . LYS A 1 37  ? -6.93   -13.895 22.039  1    51.25  ? 33  LYS A CG  1 
ATOM   278  C  CD  . LYS A 1 37  ? -7.17   -14.145 20.554  1    50.84  ? 33  LYS A CD  1 
ATOM   279  C  CE  . LYS A 1 37  ? -7.422  -15.553 20.202  1    55.6   ? 33  LYS A CE  1 
ATOM   280  N  NZ  . LYS A 1 37  ? -7.169  -15.76  18.783  1    50.16  ? 33  LYS A NZ  1 
ATOM   281  N  N   . LYS A 1 38  ? -6.518  -11.83  25.071  1    57.03  ? 34  LYS A N   1 
ATOM   282  C  CA  . LYS A 1 38  ? -6.241  -10.408 25.125  1    61.25  ? 34  LYS A CA  1 
ATOM   283  C  C   . LYS A 1 38  ? -5.533  -10.012 23.839  1    68.01  ? 34  LYS A C   1 
ATOM   284  O  O   . LYS A 1 38  ? -4.517  -10.623 23.494  1    69.18  ? 34  LYS A O   1 
ATOM   285  C  CB  . LYS A 1 38  ? -5.348  -10.066 26.324  1    67.61  ? 34  LYS A CB  1 
ATOM   286  C  CG  . LYS A 1 38  ? -5.074  -8.592  26.536  1    67.55  ? 34  LYS A CG  1 
ATOM   287  C  CD  . LYS A 1 38  ? -3.864  -8.327  27.412  1    76.5   ? 34  LYS A CD  1 
ATOM   288  C  CE  . LYS A 1 38  ? -4.039  -7.102  28.271  1    84.06  ? 34  LYS A CE  1 
ATOM   289  N  NZ  . LYS A 1 38  ? -2.764  -6.547  28.74   1    89.55  ? 34  LYS A NZ  1 
ATOM   290  N  N   . ILE A 1 39  ? -6.119  -9.035  23.118  1    70.58  ? 35  ILE A N   1 
ATOM   291  C  CA  . ILE A 1 39  ? -5.514  -8.46   21.929  1    68.65  ? 35  ILE A CA  1 
ATOM   292  C  C   . ILE A 1 39  ? -4.946  -7.114  22.349  1    73.11  ? 35  ILE A C   1 
ATOM   293  O  O   . ILE A 1 39  ? -5.677  -6.271  22.892  1    74     ? 35  ILE A O   1 
ATOM   294  C  CB  . ILE A 1 39  ? -6.525  -8.414  20.759  1    69.66  ? 35  ILE A CB  1 
ATOM   295  C  CG1 . ILE A 1 39  ? -6.538  -9.762  20.014  1    64.85  ? 35  ILE A CG1 1 
ATOM   296  C  CG2 . ILE A 1 39  ? -6.236  -7.264  19.794  1    66.31  ? 35  ILE A CG2 1 
ATOM   297  C  CD1 . ILE A 1 39  ? -7.903  -10.279 19.647  1    54.59  ? 35  ILE A CD1 1 
ATOM   298  N  N   . ARG A 1 40  ? -3.625  -6.961  22.164  1    85.47  ? 36  ARG A N   1 
ATOM   299  C  CA  . ARG A 1 40  ? -2.989  -5.707  22.548  1    100.41 ? 36  ARG A CA  1 
ATOM   300  C  C   . ARG A 1 40  ? -3.134  -4.712  21.409  1    95.58  ? 36  ARG A C   1 
ATOM   301  O  O   . ARG A 1 40  ? -2.986  -5.091  20.245  1    90.77  ? 36  ARG A O   1 
ATOM   302  C  CB  . ARG A 1 40  ? -1.554  -5.785  23.074  1    116.91 ? 36  ARG A CB  1 
ATOM   303  C  CG  . ARG A 1 40  ? -1.499  -5.547  24.578  1    121.52 ? 36  ARG A CG  1 
ATOM   304  C  CD  . ARG A 1 40  ? -0.241  -6.091  25.226  1    133.55 ? 36  ARG A CD  1 
ATOM   305  N  NE  . ARG A 1 40  ? -0.667  -6.85   26.406  1    147.14 ? 36  ARG A NE  1 
ATOM   306  C  CZ  . ARG A 1 40  ? 0.114   -7.395  27.328  1    153.61 ? 36  ARG A CZ  1 
ATOM   307  N  NH1 . ARG A 1 40  ? -0.404  -8.145  28.284  1    151.13 ? 36  ARG A NH1 1 
ATOM   308  N  NH2 . ARG A 1 40  ? 1.423   -7.226  27.262  1    154.01 ? 36  ARG A NH2 1 
ATOM   309  N  N   . LEU A 1 41  ? -3.559  -3.498  21.755  1    94.25  ? 37  LEU A N   1 
ATOM   310  C  CA  . LEU A 1 41  ? -3.886  -2.513  20.696  1    98.14  ? 37  LEU A CA  1 
ATOM   311  C  C   . LEU A 1 41  ? -2.784  -1.46   20.553  1    113.76 ? 37  LEU A C   1 
ATOM   312  O  O   . LEU A 1 41  ? -2.048  -1.227  21.535  1    109.46 ? 37  LEU A O   1 
ATOM   313  C  CB  . LEU A 1 41  ? -5.232  -1.88   21.041  1    84.78  ? 37  LEU A CB  1 
ATOM   314  C  CG  . LEU A 1 41  ? -6.426  -2.833  21.135  1    74.5   ? 37  LEU A CG  1 
ATOM   315  C  CD1 . LEU A 1 41  ? -7.649  -2.088  21.631  1    76.2   ? 37  LEU A CD1 1 
ATOM   316  C  CD2 . LEU A 1 41  ? -6.695  -3.437  19.774  1    65.92  ? 37  LEU A CD2 1 
ATOM   317  N  N   . ASP A 1 42  ? -2.664  -0.881  19.356  1    124.52 ? 38  ASP A N   1 
ATOM   318  C  CA  . ASP A 1 42  ? -1.653  0.18    19.094  1    146.39 ? 38  ASP A CA  1 
ATOM   319  C  C   . ASP A 1 42  ? -0.259  -0.327  19.47   1    164.61 ? 38  ASP A C   1 
ATOM   320  O  O   . ASP A 1 42  ? 0.647   0.516   19.603  1    176.53 ? 38  ASP A O   1 
ATOM   321  C  CB  . ASP A 1 42  ? -2.033  1.499   19.75   1    142.2  ? 38  ASP A CB  1 
ATOM   322  C  CG  . ASP A 1 42  ? -2.496  2.575   18.783  1    140.28 ? 38  ASP A CG  1 
ATOM   323  O  OD1 . ASP A 1 42  ? -3.028  2.204   17.718  1    147.36 ? 38  ASP A OD1 1 
ATOM   324  O  OD2 . ASP A 1 42  ? -2.311  3.768   19.1    1    121.62 ? 38  ASP A OD2 1 
ATOM   325  N  N   . THR A 1 43  ? -0.078  -1.643  19.617  1    174.12 ? 39  THR A N   1 
ATOM   326  C  CA  . THR A 1 43  ? 1.28    -2.181  19.833  1    176.42 ? 39  THR A CA  1 
ATOM   327  C  C   . THR A 1 43  ? 1.976   -2.036  18.502  1    195.5  ? 39  THR A C   1 
ATOM   328  O  O   . THR A 1 43  ? 3.208   -2.224  18.453  1    202.97 ? 39  THR A O   1 
ATOM   329  C  CB  . THR A 1 43  ? 1.201   -3.624  20.319  1    155.79 ? 39  THR A CB  1 
ATOM   330  O  OG1 . THR A 1 43  ? 2.548   -4.084  20.286  1    152.4  ? 39  THR A OG1 1 
ATOM   331  C  CG2 . THR A 1 43  ? 0.322   -4.486  19.432  1    140.76 ? 39  THR A CG2 1 
ATOM   332  N  N   . GLU A 1 44  ? 1.213   -1.73   17.448  1    194.26 ? 40  GLU A N   1 
ATOM   333  C  CA  . GLU A 1 44  ? 1.783   -1.439  16.112  1    172.98 ? 40  GLU A CA  1 
ATOM   334  C  C   . GLU A 1 44  ? 1.401   0.008   15.796  1    176.6  ? 40  GLU A C   1 
ATOM   335  O  O   . GLU A 1 44  ? 1.724   0.466   14.678  1    188.81 ? 40  GLU A O   1 
ATOM   336  C  CB  . GLU A 1 44  ? 1.175   -2.348  15.047  1    153.37 ? 40  GLU A CB  1 
ATOM   337  C  CG  . GLU A 1 44  ? 2.153   -2.745  13.947  1    141.28 ? 40  GLU A CG  1 
ATOM   338  C  CD  . GLU A 1 44  ? 1.491   -2.894  12.591  1    138.24 ? 40  GLU A CD  1 
ATOM   339  O  OE1 . GLU A 1 44  ? 1.422   -1.891  11.852  1    136.51 ? 40  GLU A OE1 1 
ATOM   340  O  OE2 . GLU A 1 44  ? 1.043   -4.015  12.273  1    143.52 ? 40  GLU A OE2 1 
ATOM   341  N  N   . THR A 1 45  ? 0.717   0.688   16.729  1    150.04 ? 41  THR A N   1 
ATOM   342  C  CA  . THR A 1 45  ? 0.272   2.09    16.53   1    125.91 ? 41  THR A CA  1 
ATOM   343  C  C   . THR A 1 45  ? -0.552  2.211   15.261  1    110.92 ? 41  THR A C   1 
ATOM   344  O  O   . THR A 1 45  ? -0.494  3.273   14.618  1    105.63 ? 41  THR A O   1 
ATOM   345  C  CB  . THR A 1 45  ? 1.48    3.027   16.525  1    126.53 ? 41  THR A CB  1 
ATOM   346  O  OG1 . THR A 1 45  ? 2.005   3.007   15.202  1    122.95 ? 41  THR A OG1 1 
ATOM   347  C  CG2 . THR A 1 45  ? 2.549   2.606   17.518  1    131.41 ? 41  THR A CG2 1 
ATOM   348  N  N   . GLU A 1 46  ? -1.312  1.171   14.915  1    93.78  ? 42  GLU A N   1 
ATOM   349  C  CA  . GLU A 1 46  ? -2.103  1.19    13.659  1    83.65  ? 42  GLU A CA  1 
ATOM   350  C  C   . GLU A 1 46  ? -3.556  0.847   13.991  1    71.21  ? 42  GLU A C   1 
ATOM   351  O  O   . GLU A 1 46  ? -4.314  0.537   13.065  1    70.7   ? 42  GLU A O   1 
ATOM   352  C  CB  . GLU A 1 46  ? -1.479  0.258   12.623  1    87.16  ? 42  GLU A CB  1 
ATOM   353  C  CG  . GLU A 1 46  ? -0.284  0.883   11.91   1    99.34  ? 42  GLU A CG  1 
ATOM   354  C  CD  . GLU A 1 46  ? -0.664  1.764   10.739  1    107.12 ? 42  GLU A CD  1 
ATOM   355  O  OE1 . GLU A 1 46  ? -1.517  1.332   9.94    1    102.18 ? 42  GLU A OE1 1 
ATOM   356  O  OE2 . GLU A 1 46  ? -0.109  2.876   10.626  1    110.57 ? 42  GLU A OE2 1 
ATOM   357  N  N   . GLY A 1 47  ? -3.91   0.9     15.268  1    67.23  ? 43  GLY A N   1 
ATOM   358  C  CA  . GLY A 1 47  ? -5.306  0.682   15.668  1    62.25  ? 43  GLY A CA  1 
ATOM   359  C  C   . GLY A 1 47  ? -5.624  -0.763  15.941  1    57.4   ? 43  GLY A C   1 
ATOM   360  O  O   . GLY A 1 47  ? -4.71   -1.513  16.311  1    60.16  ? 43  GLY A O   1 
ATOM   361  N  N   . VAL A 1 48  ? -6.889  -1.125  15.773  1    52.24  ? 44  VAL A N   1 
ATOM   362  C  CA  . VAL A 1 48  ? -7.315  -2.534  15.977  1    48.85  ? 44  VAL A CA  1 
ATOM   363  C  C   . VAL A 1 48  ? -6.758  -3.361  14.812  1    48.4   ? 44  VAL A C   1 
ATOM   364  O  O   . VAL A 1 48  ? -6.904  -2.951  13.655  1    46.92  ? 44  VAL A O   1 
ATOM   365  C  CB  . VAL A 1 48  ? -8.843  -2.658  16.128  1    45.85  ? 44  VAL A CB  1 
ATOM   366  C  CG1 . VAL A 1 48  ? -9.283  -4.1    16.337  1    42.41  ? 44  VAL A CG1 1 
ATOM   367  C  CG2 . VAL A 1 48  ? -9.362  -1.773  17.251  1    47.31  ? 44  VAL A CG2 1 
ATOM   368  N  N   . PRO A 1 49  ? -6.069  -4.477  15.098  1    49.35  ? 45  PRO A N   1 
ATOM   369  C  CA  . PRO A 1 49  ? -5.494  -5.296  14.048  1    48.39  ? 45  PRO A CA  1 
ATOM   370  C  C   . PRO A 1 49  ? -6.513  -5.903  13.095  1    50.91  ? 45  PRO A C   1 
ATOM   371  O  O   . PRO A 1 49  ? -7.62   -6.247  13.519  1    52.84  ? 45  PRO A O   1 
ATOM   372  C  CB  . PRO A 1 49  ? -4.775  -6.344  14.898  1    45.52  ? 45  PRO A CB  1 
ATOM   373  C  CG  . PRO A 1 49  ? -4.47   -5.639  16.185  1    46.89  ? 45  PRO A CG  1 
ATOM   374  C  CD  . PRO A 1 49  ? -5.781  -4.946  16.436  1    49.61  ? 45  PRO A CD  1 
ATOM   375  N  N   . SER A 1 50  ? -6.134  -6.047  11.829  1    52.06  ? 46  SER A N   1 
ATOM   376  C  CA  . SER A 1 50  ? -7.027  -6.632  10.798  1    49.34  ? 46  SER A CA  1 
ATOM   377  C  C   . SER A 1 50  ? -7.399  -8.07   11.173  1    48.28  ? 46  SER A C   1 
ATOM   378  O  O   . SER A 1 50  ? -8.552  -8.456  10.95   1    48.04  ? 46  SER A O   1 
ATOM   379  C  CB  . SER A 1 50  ? -6.363  -6.575  9.461   1    49.38  ? 46  SER A CB  1 
ATOM   380  O  OG  . SER A 1 50  ? -5.124  -7.267  9.482   1    60.96  ? 46  SER A OG  1 
ATOM   381  N  N   . THR A 1 51  ? -6.458  -8.811  11.748  1    46.92  ? 47  THR A N   1 
ATOM   382  C  CA  . THR A 1 51  ? -6.704  -10.201 12.166  1    48.56  ? 47  THR A CA  1 
ATOM   383  C  C   . THR A 1 51  ? -7.834  -10.247 13.157  1    42.04  ? 47  THR A C   1 
ATOM   384  O  O   . THR A 1 51  ? -8.684  -11.137 13.034  1    40.21  ? 47  THR A O   1 
ATOM   385  C  CB  . THR A 1 51  ? -5.413  -10.75  12.764  1    52.68  ? 47  THR A CB  1 
ATOM   386  O  OG1 . THR A 1 51  ? -5.008  -9.785  13.727  1    63.57  ? 47  THR A OG1 1 
ATOM   387  C  CG2 . THR A 1 51  ? -4.319  -10.917 11.727  1    60.02  ? 47  THR A CG2 1 
ATOM   388  N  N   . ALA A 1 52  ? -7.84   -9.321  14.107  1    39.86  ? 48  ALA A N   1 
ATOM   389  C  CA  . ALA A 1 52  ? -8.866  -9.305  15.166  1    41.46  ? 48  ALA A CA  1 
ATOM   390  C  C   . ALA A 1 52  ? -10.209 -8.866  14.592  1    44.77  ? 48  ALA A C   1 
ATOM   391  O  O   . ALA A 1 52  ? -11.229 -9.454  14.949  1    44.08  ? 48  ALA A O   1 
ATOM   392  C  CB  . ALA A 1 52  ? -8.407  -8.386  16.258  1    39.77  ? 48  ALA A CB  1 
ATOM   393  N  N   . ILE A 1 53  ? -10.195 -7.884  13.701  1    45.24  ? 49  ILE A N   1 
ATOM   394  C  CA  . ILE A 1 53  ? -11.447 -7.399  13.056  1    45.49  ? 49  ILE A CA  1 
ATOM   395  C  C   . ILE A 1 53  ? -12.071 -8.563  12.271  1    41.76  ? 49  ILE A C   1 
ATOM   396  O  O   . ILE A 1 53  ? -13.295 -8.724  12.326  1    38.52  ? 49  ILE A O   1 
ATOM   397  C  CB  . ILE A 1 53  ? -11.139 -6.168  12.186  1    47.62  ? 49  ILE A CB  1 
ATOM   398  C  CG1 . ILE A 1 53  ? -11.168 -4.883  13.002  1    47     ? 49  ILE A CG1 1 
ATOM   399  C  CG2 . ILE A 1 53  ? -12.064 -6.089  10.971  1    49.71  ? 49  ILE A CG2 1 
ATOM   400  C  CD1 . ILE A 1 53  ? -10.074 -3.901  12.635  1    47.9   ? 49  ILE A CD1 1 
ATOM   401  N  N   . ARG A 1 54  ? -11.237 -9.375  11.632  1    38.83  ? 50  ARG A N   1 
ATOM   402  C  CA  . ARG A 1 54  ? -11.742 -10.509 10.828  1    36.32  ? 50  ARG A CA  1 
ATOM   403  C  C   . ARG A 1 54  ? -12.202 -11.628 11.773  1    40.9   ? 50  ARG A C   1 
ATOM   404  O  O   . ARG A 1 54  ? -13.315 -12.122 11.592  1    44.13  ? 50  ARG A O   1 
ATOM   405  C  CB  . ARG A 1 54  ? -10.657 -10.941 9.839   1    33.67  ? 50  ARG A CB  1 
ATOM   406  C  CG  . ARG A 1 54  ? -10.52  -10.114 8.569   1    34.47  ? 50  ARG A CG  1 
ATOM   407  C  CD  . ARG A 1 54  ? -9.241  -10.459 7.827   1    32.66  ? 50  ARG A CD  1 
ATOM   408  N  NE  . ARG A 1 54  ? -9.205  -9.912  6.468   1    35.53  ? 50  ARG A NE  1 
ATOM   409  C  CZ  . ARG A 1 54  ? -8.201  -10.058 5.617   1    34.52  ? 50  ARG A CZ  1 
ATOM   410  N  NH1 . ARG A 1 54  ? -7.314  -11.013 5.801   1    32.95  ? 50  ARG A NH1 1 
ATOM   411  N  NH2 . ARG A 1 54  ? -8.087  -9.247  4.585   1    32.05  ? 50  ARG A NH2 1 
ATOM   412  N  N   . GLU A 1 55  ? -11.391 -11.966 12.767  1    40.36  ? 51  GLU A N   1 
ATOM   413  C  CA  . GLU A 1 55  ? -11.739 -13.066 13.699  1    38.7   ? 51  GLU A CA  1 
ATOM   414  C  C   . GLU A 1 55  ? -13.086 -12.761 14.359  1    36.02  ? 51  GLU A C   1 
ATOM   415  O  O   . GLU A 1 55  ? -13.947 -13.635 14.35   1    33.53  ? 51  GLU A O   1 
ATOM   416  C  CB  . GLU A 1 55  ? -10.64  -13.277 14.739  1    40.48  ? 51  GLU A CB  1 
ATOM   417  C  CG  . GLU A 1 55  ? -10.912 -14.448 15.676  1    43.61  ? 51  GLU A CG  1 
ATOM   418  C  CD  . GLU A 1 55  ? -9.693  -14.975 16.407  1    53.59  ? 51  GLU A CD  1 
ATOM   419  O  OE1 . GLU A 1 55  ? -8.763  -14.183 16.642  1    54.03  ? 51  GLU A OE1 1 
ATOM   420  O  OE2 . GLU A 1 55  ? -9.679  -16.177 16.737  1    63.17  ? 51  GLU A OE2 1 
ATOM   421  N  N   . ILE A 1 56  ? -13.266 -11.544 14.853  1    35.79  ? 52  ILE A N   1 
ATOM   422  C  CA  . ILE A 1 56  ? -14.509 -11.216 15.599  1    39.02  ? 52  ILE A CA  1 
ATOM   423  C  C   . ILE A 1 56  ? -15.694 -11.183 14.627  1    42.28  ? 52  ILE A C   1 
ATOM   424  O  O   . ILE A 1 56  ? -16.685 -11.868 14.905  1    42.72  ? 52  ILE A O   1 
ATOM   425  C  CB  . ILE A 1 56  ? -14.345 -9.905  16.388  1    40.73  ? 52  ILE A CB  1 
ATOM   426  C  CG1 . ILE A 1 56  ? -13.199 -9.992  17.384  1    40.64  ? 52  ILE A CG1 1 
ATOM   427  C  CG2 . ILE A 1 56  ? -15.651 -9.519  17.078  1    41.1   ? 52  ILE A CG2 1 
ATOM   428  C  CD1 . ILE A 1 56  ? -12.672 -8.645  17.837  1    39.79  ? 52  ILE A CD1 1 
ATOM   429  N  N   . SER A 1 57  ? -15.567 -10.463 13.517  1    40.52  ? 53  SER A N   1 
ATOM   430  C  CA  . SER A 1 57  ? -16.687 -10.33  12.554  1    42.61  ? 53  SER A CA  1 
ATOM   431  C  C   . SER A 1 57  ? -17.151 -11.712 12.081  1    40.73  ? 53  SER A C   1 
ATOM   432  O  O   . SER A 1 57  ? -18.373 -11.952 12.058  1    41.32  ? 53  SER A O   1 
ATOM   433  C  CB  . SER A 1 57  ? -16.303 -9.452  11.389  1    41.07  ? 53  SER A CB  1 
ATOM   434  O  OG  . SER A 1 57  ? -15.152 -9.953  10.729  1    50.08  ? 53  SER A OG  1 
ATOM   435  N  N   . LEU A 1 58  ? -16.21  -12.6   11.78   1    37.44  ? 54  LEU A N   1 
ATOM   436  C  CA  . LEU A 1 58  ? -16.582 -13.906 11.189  1    34.83  ? 54  LEU A CA  1 
ATOM   437  C  C   . LEU A 1 58  ? -17.031 -14.891 12.274  1    39.21  ? 54  LEU A C   1 
ATOM   438  O  O   . LEU A 1 58  ? -18.016 -15.586 12.046  1    45.45  ? 54  LEU A O   1 
ATOM   439  C  CB  . LEU A 1 58  ? -15.397 -14.383 10.356  1    30.69  ? 54  LEU A CB  1 
ATOM   440  C  CG  . LEU A 1 58  ? -14.975 -13.45  9.217   1    34.18  ? 54  LEU A CG  1 
ATOM   441  C  CD1 . LEU A 1 58  ? -13.809 -13.992 8.417   1    31.57  ? 54  LEU A CD1 1 
ATOM   442  C  CD2 . LEU A 1 58  ? -16.136 -13.091 8.313   1    31.33  ? 54  LEU A CD2 1 
ATOM   443  N  N   . LEU A 1 59  ? -16.371 -14.898 13.423  1    42.17  ? 55  LEU A N   1 
ATOM   444  C  CA  . LEU A 1 59  ? -16.725 -15.857 14.5    1    40.3   ? 55  LEU A CA  1 
ATOM   445  C  C   . LEU A 1 59  ? -18.075 -15.467 15.122  1    41.8   ? 55  LEU A C   1 
ATOM   446  O  O   . LEU A 1 59  ? -18.759 -16.361 15.629  1    41.21  ? 55  LEU A O   1 
ATOM   447  C  CB  . LEU A 1 59  ? -15.602 -15.952 15.53   1    41.86  ? 55  LEU A CB  1 
ATOM   448  C  CG  . LEU A 1 59  ? -14.495 -16.955 15.201  1    42.88  ? 55  LEU A CG  1 
ATOM   449  C  CD1 . LEU A 1 59  ? -13.531 -17.1   16.356  1    38.23  ? 55  LEU A CD1 1 
ATOM   450  C  CD2 . LEU A 1 59  ? -15.104 -18.29  14.833  1    38.25  ? 55  LEU A CD2 1 
ATOM   451  N  N   . LYS A 1 60  ? -18.449 -14.192 15.052  1    44.72  ? 56  LYS A N   1 
ATOM   452  C  CA  . LYS A 1 60  ? -19.769 -13.741 15.553  1    45.9   ? 56  LYS A CA  1 
ATOM   453  C  C   . LYS A 1 60  ? -20.864 -14.344 14.673  1    48.52  ? 56  LYS A C   1 
ATOM   454  O  O   . LYS A 1 60  ? -21.931 -14.678 15.207  1    51.94  ? 56  LYS A O   1 
ATOM   455  C  CB  . LYS A 1 60  ? -19.842 -12.215 15.516  1    44.32  ? 56  LYS A CB  1 
ATOM   456  C  CG  . LYS A 1 60  ? -19.433 -11.496 16.784  1    49.26  ? 56  LYS A CG  1 
ATOM   457  C  CD  . LYS A 1 60  ? -19.811 -10.022 16.736  1    52.38  ? 56  LYS A CD  1 
ATOM   458  C  CE  . LYS A 1 60  ? -21.18  -9.782  17.284  1    52.3   ? 56  LYS A CE  1 
ATOM   459  N  NZ  . LYS A 1 60  ? -21.77  -8.554  16.751  1    52.23  ? 56  LYS A NZ  1 
ATOM   460  N  N   . GLU A 1 61  ? -20.591 -14.487 13.38   1    45.31  ? 57  GLU A N   1 
ATOM   461  C  CA  . GLU A 1 61  ? -21.589 -15.02  12.423  1    50.63  ? 57  GLU A CA  1 
ATOM   462  C  C   . GLU A 1 61  ? -21.556 -16.553 12.378  1    51.18  ? 57  GLU A C   1 
ATOM   463  O  O   . GLU A 1 61  ? -22.57  -17.145 11.977  1    60.56  ? 57  GLU A O   1 
ATOM   464  C  CB  . GLU A 1 61  ? -21.23  -14.473 11.047  1    45.55  ? 57  GLU A CB  1 
ATOM   465  C  CG  . GLU A 1 61  ? -21.59  -13.011 10.824  1    47.12  ? 57  GLU A CG  1 
ATOM   466  C  CD  . GLU A 1 61  ? -21.276 -12.636 9.39    1    55.12  ? 57  GLU A CD  1 
ATOM   467  O  OE1 . GLU A 1 61  ? -21.026 -11.447 9.134   1    61.41  ? 57  GLU A OE1 1 
ATOM   468  O  OE2 . GLU A 1 61  ? -21.283 -13.533 8.528   1    51.96  ? 57  GLU A OE2 1 
ATOM   469  N  N   . LEU A 1 62  ? -20.452 -17.169 12.79   1    43.95  ? 58  LEU A N   1 
ATOM   470  C  CA  . LEU A 1 62  ? -20.303 -18.64  12.667  1    43.19  ? 58  LEU A CA  1 
ATOM   471  C  C   . LEU A 1 62  ? -20.699 -19.336 13.971  1    42.85  ? 58  LEU A C   1 
ATOM   472  O  O   . LEU A 1 62  ? -19.852 -19.455 14.86   1    56.22  ? 58  LEU A O   1 
ATOM   473  C  CB  . LEU A 1 62  ? -18.87  -18.973 12.26   1    39.09  ? 58  LEU A CB  1 
ATOM   474  C  CG  . LEU A 1 62  ? -18.426 -18.506 10.872  1    39.44  ? 58  LEU A CG  1 
ATOM   475  C  CD1 . LEU A 1 62  ? -16.923 -18.634 10.753  1    34.49  ? 58  LEU A CD1 1 
ATOM   476  C  CD2 . LEU A 1 62  ? -19.114 -19.271 9.763   1    37.09  ? 58  LEU A CD2 1 
ATOM   477  N  N   . ASN A 1 63  ? -21.932 -19.838 14.037  1    43.01  ? 59  ASN A N   1 
ATOM   478  C  CA  . ASN A 1 63  ? -22.385 -20.585 15.243  1    39.92  ? 59  ASN A CA  1 
ATOM   479  C  C   . ASN A 1 63  ? -22.557 -22.06  14.862  1    37.45  ? 59  ASN A C   1 
ATOM   480  O  O   . ASN A 1 63  ? -23.655 -22.425 14.389  1    42.07  ? 59  ASN A O   1 
ATOM   481  C  CB  . ASN A 1 63  ? -23.635 -19.946 15.834  1    48.11  ? 59  ASN A CB  1 
ATOM   482  C  CG  . ASN A 1 63  ? -23.32  -18.62  16.484  1    70.79  ? 59  ASN A CG  1 
ATOM   483  O  OD1 . ASN A 1 63  ? -22.172 -18.373 16.871  1    79.52  ? 59  ASN A OD1 1 
ATOM   484  N  ND2 . ASN A 1 63  ? -24.321 -17.765 16.633  1    68.96  ? 59  ASN A ND2 1 
ATOM   485  N  N   . HIS A 1 64  ? -21.507 -22.867 15.047  1    33.99  ? 60  HIS A N   1 
ATOM   486  C  CA  . HIS A 1 64  ? -21.563 -24.304 14.663  1    31.48  ? 60  HIS A CA  1 
ATOM   487  C  C   . HIS A 1 64  ? -20.903 -25.151 15.757  1    34.54  ? 60  HIS A C   1 
ATOM   488  O  O   . HIS A 1 64  ? -19.821 -24.779 16.25   1    34.43  ? 60  HIS A O   1 
ATOM   489  C  CB  . HIS A 1 64  ? -20.91  -24.513 13.293  1    31.44  ? 60  HIS A CB  1 
ATOM   490  C  CG  . HIS A 1 64  ? -21.01  -25.913 12.792  1    32.64  ? 60  HIS A CG  1 
ATOM   491  N  ND1 . HIS A 1 64  ? -20.02  -26.849 12.993  1    31.54  ? 60  HIS A ND1 1 
ATOM   492  C  CD2 . HIS A 1 64  ? -21.981 -26.538 12.117  1    33.37  ? 60  HIS A CD2 1 
ATOM   493  C  CE1 . HIS A 1 64  ? -20.393 -27.999 12.452  1    33.64  ? 60  HIS A CE1 1 
ATOM   494  N  NE2 . HIS A 1 64  ? -21.577 -27.831 11.909  1    33.45  ? 60  HIS A NE2 1 
ATOM   495  N  N   . PRO A 1 65  ? -21.517 -26.282 16.169  1    37.43  ? 61  PRO A N   1 
ATOM   496  C  CA  . PRO A 1 65  ? -20.965 -27.11  17.235  1    34.79  ? 61  PRO A CA  1 
ATOM   497  C  C   . PRO A 1 65  ? -19.508 -27.51  17.036  1    35.05  ? 61  PRO A C   1 
ATOM   498  O  O   . PRO A 1 65  ? -18.873 -27.958 18.008  1    36.67  ? 61  PRO A O   1 
ATOM   499  C  CB  . PRO A 1 65  ? -21.891 -28.338 17.213  1    33.79  ? 61  PRO A CB  1 
ATOM   500  C  CG  . PRO A 1 65  ? -23.198 -27.799 16.685  1    33.05  ? 61  PRO A CG  1 
ATOM   501  C  CD  . PRO A 1 65  ? -22.778 -26.78  15.644  1    32.62  ? 61  PRO A CD  1 
ATOM   502  N  N   . ASN A 1 66  ? -18.995 -27.382 15.81   1    30.54  ? 62  ASN A N   1 
ATOM   503  C  CA  . ASN A 1 66  ? -17.604 -27.806 15.519  1    30.77  ? 62  ASN A CA  1 
ATOM   504  C  C   . ASN A 1 66  ? -16.794 -26.561 15.174  1    32.95  ? 62  ASN A C   1 
ATOM   505  O  O   . ASN A 1 66  ? -15.738 -26.693 14.549  1    33.36  ? 62  ASN A O   1 
ATOM   506  C  CB  . ASN A 1 66  ? -17.601 -28.954 14.521  1    29.85  ? 62  ASN A CB  1 
ATOM   507  C  CG  . ASN A 1 66  ? -18.299 -30.173 15.063  1    33.35  ? 62  ASN A CG  1 
ATOM   508  O  OD1 . ASN A 1 66  ? -19.303 -30.615 14.499  1    38.4   ? 62  ASN A OD1 1 
ATOM   509  N  ND2 . ASN A 1 66  ? -17.787 -30.722 16.152  1    33.46  ? 62  ASN A ND2 1 
ATOM   510  N  N   . ILE A 1 67  ? -17.31  -25.396 15.543  1    32.64  ? 63  ILE A N   1 
ATOM   511  C  CA  . ILE A 1 67  ? -16.541 -24.136 15.39   1    29.9   ? 63  ILE A CA  1 
ATOM   512  C  C   . ILE A 1 67  ? -16.464 -23.54  16.799  1    32.65  ? 63  ILE A C   1 
ATOM   513  O  O   . ILE A 1 67  ? -17.486 -23.541 17.483  1    40.45  ? 63  ILE A O   1 
ATOM   514  C  CB  . ILE A 1 67  ? -17.181 -23.179 14.37   1    29.94  ? 63  ILE A CB  1 
ATOM   515  C  CG1 . ILE A 1 67  ? -17.3   -23.817 12.992  1    31.34  ? 63  ILE A CG1 1 
ATOM   516  C  CG2 . ILE A 1 67  ? -16.422 -21.856 14.31   1    30.19  ? 63  ILE A CG2 1 
ATOM   517  C  CD1 . ILE A 1 67  ? -17.947 -22.92  11.956  1    32.23  ? 63  ILE A CD1 1 
ATOM   518  N  N   . VAL A 1 68  ? -15.278 -23.11  17.222  1    38.32  ? 64  VAL A N   1 
ATOM   519  C  CA  . VAL A 1 68  ? -15.082 -22.487 18.565  1    36.62  ? 64  VAL A CA  1 
ATOM   520  C  C   . VAL A 1 68  ? -16.076 -21.335 18.733  1    34.3   ? 64  VAL A C   1 
ATOM   521  O  O   . VAL A 1 68  ? -16.325 -20.606 17.768  1    35.44  ? 64  VAL A O   1 
ATOM   522  C  CB  . VAL A 1 68  ? -13.631 -22.03  18.831  1    36.45  ? 64  VAL A CB  1 
ATOM   523  C  CG1 . VAL A 1 68  ? -13.218 -20.829 17.992  1    30.76  ? 64  VAL A CG1 1 
ATOM   524  C  CG2 . VAL A 1 68  ? -13.354 -21.801 20.311  1    33.83  ? 64  VAL A CG2 1 
ATOM   525  N  N   . LYS A 1 69  ? -16.595 -21.18  19.944  1    39.36  ? 65  LYS A N   1 
ATOM   526  C  CA  . LYS A 1 69  ? -17.635 -20.16  20.182  1    41.13  ? 65  LYS A CA  1 
ATOM   527  C  C   . LYS A 1 69  ? -17.064 -18.891 20.806  1    38.8   ? 65  LYS A C   1 
ATOM   528  O  O   . LYS A 1 69  ? -16.427 -18.995 21.857  1    40.52  ? 65  LYS A O   1 
ATOM   529  C  CB  . LYS A 1 69  ? -18.726 -20.744 21.078  1    41.97  ? 65  LYS A CB  1 
ATOM   530  C  CG  . LYS A 1 69  ? -19.547 -21.855 20.454  1    60.52  ? 65  LYS A CG  1 
ATOM   531  C  CD  . LYS A 1 69  ? -20.597 -22.405 21.41   1    81.34  ? 65  LYS A CD  1 
ATOM   532  C  CE  . LYS A 1 69  ? -21.43  -23.487 20.797  1    87.45  ? 65  LYS A CE  1 
ATOM   533  N  NZ  . LYS A 1 69  ? -22.415 -24.014 21.745  1    76.95  ? 65  LYS A NZ  1 
ATOM   534  N  N   . LEU A 1 70  ? -17.264 -17.758 20.139  1    35.75  ? 66  LEU A N   1 
ATOM   535  C  CA  . LEU A 1 70  ? -16.914 -16.452 20.729  1    35.82  ? 66  LEU A CA  1 
ATOM   536  C  C   . LEU A 1 70  ? -18.134 -16.096 21.572  1    41.4   ? 66  LEU A C   1 
ATOM   537  O  O   . LEU A 1 70  ? -19.214 -15.941 20.992  1    41.95  ? 66  LEU A O   1 
ATOM   538  C  CB  . LEU A 1 70  ? -16.657 -15.408 19.65   1    35.11  ? 66  LEU A CB  1 
ATOM   539  C  CG  . LEU A 1 70  ? -16.054 -14.078 20.108  1    36.07  ? 66  LEU A CG  1 
ATOM   540  C  CD1 . LEU A 1 70  ? -14.779 -14.303 20.893  1    36.97  ? 66  LEU A CD1 1 
ATOM   541  C  CD2 . LEU A 1 70  ? -15.777 -13.237 18.878  1    35.4   ? 66  LEU A CD2 1 
ATOM   542  N  N   . LEU A 1 71  ? -17.97  -16.031 22.888  1    41.41  ? 67  LEU A N   1 
ATOM   543  C  CA  . LEU A 1 71  ? -19.131 -15.809 23.776  1    39.34  ? 67  LEU A CA  1 
ATOM   544  C  C   . LEU A 1 71  ? -19.361 -14.308 23.952  1    41.65  ? 67  LEU A C   1 
ATOM   545  O  O   . LEU A 1 71  ? -20.522 -13.902 24.076  1    43.61  ? 67  LEU A O   1 
ATOM   546  C  CB  . LEU A 1 71  ? -18.81  -16.528 25.081  1    40.71  ? 67  LEU A CB  1 
ATOM   547  C  CG  . LEU A 1 71  ? -18.462 -18.012 24.965  1    40.73  ? 67  LEU A CG  1 
ATOM   548  C  CD1 . LEU A 1 71  ? -18.036 -18.519 26.325  1    40.22  ? 67  LEU A CD1 1 
ATOM   549  C  CD2 . LEU A 1 71  ? -19.67  -18.776 24.471  1    38.41  ? 67  LEU A CD2 1 
ATOM   550  N  N   . ASP A 1 72  ? -18.286 -13.531 23.908  1    42.05  ? 68  ASP A N   1 
ATOM   551  C  CA  . ASP A 1 72  ? -18.395 -12.068 24.094  1    44.06  ? 68  ASP A CA  1 
ATOM   552  C  C   . ASP A 1 72  ? -17.111 -11.365 23.664  1    44.74  ? 68  ASP A C   1 
ATOM   553  O  O   . ASP A 1 72  ? -16.106 -12.051 23.444  1    42.14  ? 68  ASP A O   1 
ATOM   554  C  CB  . ASP A 1 72  ? -18.703 -11.707 25.538  1    46.16  ? 68  ASP A CB  1 
ATOM   555  C  CG  . ASP A 1 72  ? -19.483 -10.418 25.719  1    51.39  ? 68  ASP A CG  1 
ATOM   556  O  OD1 . ASP A 1 72  ? -20.421 -10.191 24.936  1    53.26  ? 68  ASP A OD1 1 
ATOM   557  O  OD2 . ASP A 1 72  ? -19.126 -9.652  26.623  1    55.23  ? 68  ASP A OD2 1 
ATOM   558  N  N   . VAL A 1 73  ? -17.174 -10.041 23.539  1    47.1   ? 69  VAL A N   1 
ATOM   559  C  CA  . VAL A 1 73  ? -15.973 -9.219  23.217  1    49.5   ? 69  VAL A CA  1 
ATOM   560  C  C   . VAL A 1 73  ? -15.981 -8.022  24.181  1    51.4   ? 69  VAL A C   1 
ATOM   561  O  O   . VAL A 1 73  ? -17.009 -7.336  24.249  1    54.54  ? 69  VAL A O   1 
ATOM   562  C  CB  . VAL A 1 73  ? -15.938 -8.758  21.747  1    48.57  ? 69  VAL A CB  1 
ATOM   563  C  CG1 . VAL A 1 73  ? -14.849 -7.724  21.497  1    48.37  ? 69  VAL A CG1 1 
ATOM   564  C  CG2 . VAL A 1 73  ? -15.799 -9.926  20.782  1    45.14  ? 69  VAL A CG2 1 
ATOM   565  N  N   . ILE A 1 74  ? -14.894 -7.813  24.924  1    53.55  ? 70  ILE A N   1 
ATOM   566  C  CA  . ILE A 1 74  ? -14.791 -6.638  25.842  1    58.7   ? 70  ILE A CA  1 
ATOM   567  C  C   . ILE A 1 74  ? -13.938 -5.579  25.135  1    61.19  ? 70  ILE A C   1 
ATOM   568  O  O   . ILE A 1 74  ? -12.764 -5.865  24.856  1    57.8   ? 70  ILE A O   1 
ATOM   569  C  CB  . ILE A 1 74  ? -14.279 -7.03   27.24   1    60.01  ? 70  ILE A CB  1 
ATOM   570  C  CG1 . ILE A 1 74  ? -15.399 -7.614  28.093  1    59.75  ? 70  ILE A CG1 1 
ATOM   571  C  CG2 . ILE A 1 74  ? -13.62  -5.843  27.939  1    61.89  ? 70  ILE A CG2 1 
ATOM   572  C  CD1 . ILE A 1 74  ? -15.69  -9.079  27.831  1    56.59  ? 70  ILE A CD1 1 
ATOM   573  N  N   . HIS A 1 75  ? -14.527 -4.415  24.851  1    70.5   ? 71  HIS A N   1 
ATOM   574  C  CA  . HIS A 1 75  ? -13.851 -3.368  24.038  1    82.78  ? 71  HIS A CA  1 
ATOM   575  C  C   . HIS A 1 75  ? -13.359 -2.205  24.899  1    86.05  ? 71  HIS A C   1 
ATOM   576  O  O   . HIS A 1 75  ? -14.129 -1.251  25.119  1    84.11  ? 71  HIS A O   1 
ATOM   577  C  CB  . HIS A 1 75  ? -14.84  -2.851  22.99   1    84.08  ? 71  HIS A CB  1 
ATOM   578  C  CG  . HIS A 1 75  ? -14.248 -2.281  21.75   1    95.54  ? 71  HIS A CG  1 
ATOM   579  N  ND1 . HIS A 1 75  ? -14.996 -1.509  20.889  1    96.16  ? 71  HIS A ND1 1 
ATOM   580  C  CD2 . HIS A 1 75  ? -13.029 -2.359  21.215  1    97.18  ? 71  HIS A CD2 1 
ATOM   581  C  CE1 . HIS A 1 75  ? -14.24  -1.137  19.871  1    98.12  ? 71  HIS A CE1 1 
ATOM   582  N  NE2 . HIS A 1 75  ? -13.046 -1.654  20.042  1    94.9   ? 71  HIS A NE2 1 
ATOM   583  N  N   . THR A 1 76  ? -12.105 -2.272  25.346  1    99.82  ? 72  THR A N   1 
ATOM   584  C  CA  . THR A 1 76  ? -11.517 -1.153  26.114  1    109.99 ? 72  THR A CA  1 
ATOM   585  C  C   . THR A 1 76  ? -10.617 -0.382  25.18   1    116.26 ? 72  THR A C   1 
ATOM   586  O  O   . THR A 1 76  ? -10.115 -0.981  24.212  1    96.22  ? 72  THR A O   1 
ATOM   587  C  CB  . THR A 1 76  ? -10.762 -1.678  27.333  1    103.65 ? 72  THR A CB  1 
ATOM   588  O  OG1 . THR A 1 76  ? -11.624 -2.648  27.916  1    102.36 ? 72  THR A OG1 1 
ATOM   589  C  CG2 . THR A 1 76  ? -10.45  -0.592  28.346  1    105.26 ? 72  THR A CG2 1 
ATOM   590  N  N   . GLU A 1 77  ? -10.418 0.904   25.45   1    120.71 ? 73  GLU A N   1 
ATOM   591  C  CA  . GLU A 1 77  ? -9.614  1.764   24.555  1    125.32 ? 73  GLU A CA  1 
ATOM   592  C  C   . GLU A 1 77  ? -8.212  1.193   24.355  1    124.63 ? 73  GLU A C   1 
ATOM   593  O  O   . GLU A 1 77  ? -7.674  1.352   23.241  1    124.4  ? 73  GLU A O   1 
ATOM   594  C  CB  . GLU A 1 77  ? -9.453  3.125   25.217  1    144.98 ? 73  GLU A CB  1 
ATOM   595  C  CG  . GLU A 1 77  ? -9.399  4.276   24.218  1    175.43 ? 73  GLU A CG  1 
ATOM   596  C  CD  . GLU A 1 77  ? -7.981  4.692   23.881  1    185.41 ? 73  GLU A CD  1 
ATOM   597  O  OE1 . GLU A 1 77  ? -7.654  4.768   22.678  1    189.16 ? 73  GLU A OE1 1 
ATOM   598  O  OE2 . GLU A 1 77  ? -7.203  4.931   24.828  1    181.32 ? 73  GLU A OE2 1 
ATOM   599  N  N   . ASN A 1 78  ? -7.642  0.563   25.38   1    119.96 ? 74  ASN A N   1 
ATOM   600  C  CA  . ASN A 1 78  ? -6.229  0.115   25.274  1    110.63 ? 74  ASN A CA  1 
ATOM   601  C  C   . ASN A 1 78  ? -6.156  -1.397  25.076  1    102.82 ? 74  ASN A C   1 
ATOM   602  O  O   . ASN A 1 78  ? -5.069  -1.888  24.723  1    104.21 ? 74  ASN A O   1 
ATOM   603  C  CB  . ASN A 1 78  ? -5.436  0.541   26.503  1    112.17 ? 74  ASN A CB  1 
ATOM   604  C  CG  . ASN A 1 78  ? -4.827  1.912   26.345  1    117.05 ? 74  ASN A CG  1 
ATOM   605  O  OD1 . ASN A 1 78  ? -3.6    2.052   26.361  1    118.5  ? 74  ASN A OD1 1 
ATOM   606  N  ND2 . ASN A 1 78  ? -5.659  2.932   26.193  1    119.11 ? 74  ASN A ND2 1 
ATOM   607  N  N   . LYS A 1 79  ? -7.259  -2.107  25.318  1    98.55  ? 75  LYS A N   1 
ATOM   608  C  CA  . LYS A 1 79  ? -7.211  -3.59   25.242  1    91.68  ? 75  LYS A CA  1 
ATOM   609  C  C   . LYS A 1 79  ? -8.524  -4.17   24.702  1    75.49  ? 75  LYS A C   1 
ATOM   610  O  O   . LYS A 1 79  ? -9.594  -3.661  25.06   1    70.85  ? 75  LYS A O   1 
ATOM   611  C  CB  . LYS A 1 79  ? -6.952  -4.166  26.635  1    94.76  ? 75  LYS A CB  1 
ATOM   612  C  CG  . LYS A 1 79  ? -5.543  -4.02   27.181  1    97.84  ? 75  LYS A CG  1 
ATOM   613  C  CD  . LYS A 1 79  ? -5.51   -3.369  28.558  1    101.04 ? 75  LYS A CD  1 
ATOM   614  C  CE  . LYS A 1 79  ? -4.113  -3.145  29.041  1    102.53 ? 75  LYS A CE  1 
ATOM   615  N  NZ  . LYS A 1 79  ? -3.26   -2.585  27.99   1    107.74 ? 75  LYS A NZ  1 
ATOM   616  N  N   . LEU A 1 80  ? -8.431  -5.19   23.856  1    66.03  ? 76  LEU A N   1 
ATOM   617  C  CA  . LEU A 1 80  ? -9.635  -5.895  23.362  1    61.98  ? 76  LEU A CA  1 
ATOM   618  C  C   . LEU A 1 80  ? -9.592  -7.291  23.983  1    60.38  ? 76  LEU A C   1 
ATOM   619  O  O   . LEU A 1 80  ? -8.539  -7.943  23.895  1    56.17  ? 76  LEU A O   1 
ATOM   620  C  CB  . LEU A 1 80  ? -9.577  -5.946  21.84   1    58.61  ? 76  LEU A CB  1 
ATOM   621  C  CG  . LEU A 1 80  ? -10.867 -6.298  21.1    1    55.29  ? 76  LEU A CG  1 
ATOM   622  C  CD1 . LEU A 1 80  ? -12.01  -5.505  21.675  1    61.06  ? 76  LEU A CD1 1 
ATOM   623  C  CD2 . LEU A 1 80  ? -10.665 -5.947  19.642  1    52.51  ? 76  LEU A CD2 1 
ATOM   624  N  N   . TYR A 1 81  ? -10.685 -7.703  24.617  1    58.88  ? 77  TYR A N   1 
ATOM   625  C  CA  . TYR A 1 81  ? -10.74  -9.068  25.203  1    56.28  ? 77  TYR A CA  1 
ATOM   626  C  C   . TYR A 1 81  ? -11.744 -9.905  24.436  1    51.63  ? 77  TYR A C   1 
ATOM   627  O  O   . TYR A 1 81  ? -12.885 -9.482  24.227  1    49.21  ? 77  TYR A O   1 
ATOM   628  C  CB  . TYR A 1 81  ? -11.054 -9.054  26.701  1    55.66  ? 77  TYR A CB  1 
ATOM   629  C  CG  . TYR A 1 81  ? -10.061 -8.277  27.547  1    58.32  ? 77  TYR A CG  1 
ATOM   630  C  CD1 . TYR A 1 81  ? -8.89   -8.866  28.001  1    62     ? 77  TYR A CD1 1 
ATOM   631  C  CD2 . TYR A 1 81  ? -10.302 -6.955  27.886  1    61.34  ? 77  TYR A CD2 1 
ATOM   632  C  CE1 . TYR A 1 81  ? -7.986  -8.159  28.774  1    66.02  ? 77  TYR A CE1 1 
ATOM   633  C  CE2 . TYR A 1 81  ? -9.409  -6.238  28.658  1    64.58  ? 77  TYR A CE2 1 
ATOM   634  C  CZ  . TYR A 1 81  ? -8.251  -6.843  29.103  1    66.67  ? 77  TYR A CZ  1 
ATOM   635  O  OH  . TYR A 1 81  ? -7.38   -6.123  29.859  1    77.77  ? 77  TYR A OH  1 
ATOM   636  N  N   . LEU A 1 82  ? -11.3   -11.078 24.006  1    49.78  ? 78  LEU A N   1 
ATOM   637  C  CA  . LEU A 1 82  ? -12.199 -12.008 23.291  1    47.61  ? 78  LEU A CA  1 
ATOM   638  C  C   . LEU A 1 82  ? -12.535 -13.144 24.259  1    50.38  ? 78  LEU A C   1 
ATOM   639  O  O   . LEU A 1 82  ? -11.602 -13.768 24.776  1    53.04  ? 78  LEU A O   1 
ATOM   640  C  CB  . LEU A 1 82  ? -11.513 -12.526 22.032  1    44.62  ? 78  LEU A CB  1 
ATOM   641  C  CG  . LEU A 1 82  ? -11.114 -11.506 20.965  1    43.56  ? 78  LEU A CG  1 
ATOM   642  C  CD1 . LEU A 1 82  ? -11.187 -12.2   19.621  1    42.45  ? 78  LEU A CD1 1 
ATOM   643  C  CD2 . LEU A 1 82  ? -11.984 -10.271 20.973  1    43.48  ? 78  LEU A CD2 1 
ATOM   644  N  N   . VAL A 1 83  ? -13.821 -13.375 24.507  1    47.05  ? 79  VAL A N   1 
ATOM   645  C  CA  . VAL A 1 83  ? -14.214 -14.404 25.455  1    44.54  ? 79  VAL A CA  1 
ATOM   646  C  C   . VAL A 1 83  ? -14.652 -15.627 24.673  1    43.61  ? 79  VAL A C   1 
ATOM   647  O  O   . VAL A 1 83  ? -15.671 -15.586 23.993  1    46.84  ? 79  VAL A O   1 
ATOM   648  C  CB  . VAL A 1 83  ? -15.328 -13.982 26.422  1    43.18  ? 79  VAL A CB  1 
ATOM   649  C  CG1 . VAL A 1 83  ? -15.595 -15.057 27.459  1    39.82  ? 79  VAL A CG1 1 
ATOM   650  C  CG2 . VAL A 1 83  ? -14.996 -12.655 27.075  1    44.04  ? 79  VAL A CG2 1 
ATOM   651  N  N   . PHE A 1 84  ? -13.871 -16.708 24.787  1    41.09  ? 80  PHE A N   1 
ATOM   652  C  CA  . PHE A 1 84  ? -14.182 -17.949 24.096  1    39.55  ? 80  PHE A CA  1 
ATOM   653  C  C   . PHE A 1 84  ? -14.616 -19.024 25.093  1    41.48  ? 80  PHE A C   1 
ATOM   654  O  O   . PHE A 1 84  ? -14.298 -18.976 26.285  1    46.57  ? 80  PHE A O   1 
ATOM   655  C  CB  . PHE A 1 84  ? -12.974 -18.476 23.342  1    35.98  ? 80  PHE A CB  1 
ATOM   656  C  CG  . PHE A 1 84  ? -12.494 -17.662 22.166  1    35.09  ? 80  PHE A CG  1 
ATOM   657  C  CD1 . PHE A 1 84  ? -12.921 -17.971 20.882  1    33.94  ? 80  PHE A CD1 1 
ATOM   658  C  CD2 . PHE A 1 84  ? -11.529 -16.675 22.321  1    37.3   ? 80  PHE A CD2 1 
ATOM   659  C  CE1 . PHE A 1 84  ? -12.413 -17.291 19.778  1    34.39  ? 80  PHE A CE1 1 
ATOM   660  C  CE2 . PHE A 1 84  ? -11.012 -16.005 21.206  1    38.44  ? 80  PHE A CE2 1 
ATOM   661  C  CZ  . PHE A 1 84  ? -11.46  -16.307 19.935  1    35.2   ? 80  PHE A CZ  1 
ATOM   662  N  N   . GLU A 1 85  ? -15.408 -19.96  24.587  1    39.11  ? 81  GLU A N   1 
ATOM   663  C  CA  . GLU A 1 85  ? -15.649 -21.236 25.233  1    41.29  ? 81  GLU A CA  1 
ATOM   664  C  C   . GLU A 1 85  ? -14.314 -21.965 25.436  1    44.88  ? 81  GLU A C   1 
ATOM   665  O  O   . GLU A 1 85  ? -13.418 -21.916 24.598  1    45.86  ? 81  GLU A O   1 
ATOM   666  C  CB  . GLU A 1 85  ? -16.555 -21.965 24.237  1    43.25  ? 81  GLU A CB  1 
ATOM   667  C  CG  . GLU A 1 85  ? -17.031 -23.329 24.699  1    46.19  ? 81  GLU A CG  1 
ATOM   668  C  CD  . GLU A 1 85  ? -17.964 -24.04  23.747  1    45.91  ? 81  GLU A CD  1 
ATOM   669  O  OE1 . GLU A 1 85  ? -18.25  -23.505 22.658  1    50.83  ? 81  GLU A OE1 1 
ATOM   670  O  OE2 . GLU A 1 85  ? -18.483 -25.086 24.134  1    44.57  ? 81  GLU A OE2 1 
ATOM   671  N  N   . PHE A 1 86  ? -14.17  -22.658 26.566  1    45.44  ? 82  PHE A N   1 
ATOM   672  C  CA  . PHE A 1 86  ? -12.937 -23.357 26.873  1    44.32  ? 82  PHE A CA  1 
ATOM   673  C  C   . PHE A 1 86  ? -13.015 -24.817 26.44   1    43.4   ? 82  PHE A C   1 
ATOM   674  O  O   . PHE A 1 86  ? -13.994 -25.482 26.727  1    45.4   ? 82  PHE A O   1 
ATOM   675  C  CB  . PHE A 1 86  ? -12.659 -23.32  28.371  1    46.62  ? 82  PHE A CB  1 
ATOM   676  C  CG  . PHE A 1 86  ? -11.442 -24.134 28.785  1    48     ? 82  PHE A CG  1 
ATOM   677  C  CD1 . PHE A 1 86  ? -10.153 -23.633 28.598  1    44.43  ? 82  PHE A CD1 1 
ATOM   678  C  CD2 . PHE A 1 86  ? -11.596 -25.413 29.346  1    46.11  ? 82  PHE A CD2 1 
ATOM   679  C  CE1 . PHE A 1 86  ? -9.049  -24.399 28.976  1    43.73  ? 82  PHE A CE1 1 
ATOM   680  C  CE2 . PHE A 1 86  ? -10.492 -26.159 29.726  1    45.75  ? 82  PHE A CE2 1 
ATOM   681  C  CZ  . PHE A 1 86  ? -9.224  -25.649 29.548  1    45.08  ? 82  PHE A CZ  1 
ATOM   682  N  N   . LEU A 1 87  ? -11.948 -25.296 25.789  1    40.57  ? 83  LEU A N   1 
ATOM   683  C  CA  . LEU A 1 87  ? -11.692 -26.699 25.503  1    41.61  ? 83  LEU A CA  1 
ATOM   684  C  C   . LEU A 1 87  ? -10.317 -27.094 26.054  1    43.12  ? 83  LEU A C   1 
ATOM   685  O  O   . LEU A 1 87  ? -9.383  -26.297 26.007  1    41.89  ? 83  LEU A O   1 
ATOM   686  C  CB  . LEU A 1 87  ? -11.783 -26.927 24      1    41.34  ? 83  LEU A CB  1 
ATOM   687  C  CG  . LEU A 1 87  ? -13.184 -26.832 23.404  1    43.8   ? 83  LEU A CG  1 
ATOM   688  C  CD1 . LEU A 1 87  ? -13.453 -25.447 22.88   1    38.99  ? 83  LEU A CD1 1 
ATOM   689  C  CD2 . LEU A 1 87  ? -13.327 -27.895 22.306  1    48.81  ? 83  LEU A CD2 1 
ATOM   690  N  N   A HIS A 1 88  ? -10.203 -28.358 26.476  0.5  42.2   ? 84  HIS A N   1 
ATOM   691  N  N   B HIS A 1 88  ? -10.2   -28.334 26.566  0.5  44.88  ? 84  HIS A N   1 
ATOM   692  C  CA  A HIS A 1 88  ? -9.149  -28.781 27.382  0.5  44.32  ? 84  HIS A CA  1 
ATOM   693  C  CA  B HIS A 1 88  ? -9.083  -28.73  27.419  0.5  49.41  ? 84  HIS A CA  1 
ATOM   694  C  C   A HIS A 1 88  ? -7.797  -28.891 26.671  0.5  45.29  ? 84  HIS A C   1 
ATOM   695  C  C   B HIS A 1 88  ? -7.758  -28.841 26.659  0.5  48.15  ? 84  HIS A C   1 
ATOM   696  O  O   A HIS A 1 88  ? -6.749  -28.698 27.296  0.5  46.92  ? 84  HIS A O   1 
ATOM   697  O  O   B HIS A 1 88  ? -6.688  -28.641 27.246  0.5  49.17  ? 84  HIS A O   1 
ATOM   698  C  CB  A HIS A 1 88  ? -9.623  -29.992 28.196  0.5  44.06  ? 84  HIS A CB  1 
ATOM   699  C  CB  B HIS A 1 88  ? -9.391  -29.973 28.275  0.5  54.81  ? 84  HIS A CB  1 
ATOM   700  C  CG  A HIS A 1 88  ? -11.027 -29.835 28.714  0.5  41.64  ? 84  HIS A CG  1 
ATOM   701  C  CG  B HIS A 1 88  ? -9.224  -31.322 27.621  0.5  57.38  ? 84  HIS A CG  1 
ATOM   702  N  ND1 A HIS A 1 88  ? -12.164 -29.756 27.918  0.5  36.6   ? 84  HIS A ND1 1 
ATOM   703  N  ND1 B HIS A 1 88  ? -10.074 -31.802 26.641  0.5  60.21  ? 84  HIS A ND1 1 
ATOM   704  C  CD2 A HIS A 1 88  ? -11.425 -29.713 30      0.5  41.81  ? 84  HIS A CD2 1 
ATOM   705  C  CD2 B HIS A 1 88  ? -8.325  -32.306 27.831  0.5  59.13  ? 84  HIS A CD2 1 
ATOM   706  C  CE1 A HIS A 1 88  ? -13.206 -29.581 28.697  0.5  38.15  ? 84  HIS A CE1 1 
ATOM   707  C  CE1 B HIS A 1 88  ? -9.685  -33.023 26.267  0.5  60.5   ? 84  HIS A CE1 1 
ATOM   708  N  NE2 A HIS A 1 88  ? -12.786 -29.571 29.972  0.5  41.74  ? 84  HIS A NE2 1 
ATOM   709  N  NE2 B HIS A 1 88  ? -8.629  -33.357 26.993  0.5  59.48  ? 84  HIS A NE2 1 
ATOM   710  N  N   . GLN A 1 89  ? -7.818  -29.139 25.358  1    44.55  ? 85  GLN A N   1 
ATOM   711  C  CA  . GLN A 1 89  ? -6.596  -29.505 24.648  1    46.37  ? 85  GLN A CA  1 
ATOM   712  C  C   . GLN A 1 89  ? -6.758  -29.242 23.149  1    43.26  ? 85  GLN A C   1 
ATOM   713  O  O   . GLN A 1 89  ? -7.863  -29.036 22.678  1    40.57  ? 85  GLN A O   1 
ATOM   714  C  CB  . GLN A 1 89  ? -6.404  -30.975 25.029  1    51.35  ? 85  GLN A CB  1 
ATOM   715  C  CG  . GLN A 1 89  ? -5.176  -31.656 24.459  1    64.83  ? 85  GLN A CG  1 
ATOM   716  C  CD  . GLN A 1 89  ? -4.633  -32.654 25.455  1    85.29  ? 85  GLN A CD  1 
ATOM   717  O  OE1 . GLN A 1 89  ? -4.332  -32.277 26.597  1    106.57 ? 85  GLN A OE1 1 
ATOM   718  N  NE2 . GLN A 1 89  ? -4.538  -33.923 25.061  1    79.59  ? 85  GLN A NE2 1 
ATOM   719  N  N   . ASP A 1 90  ? -5.644  -29.214 22.417  1    41.71  ? 86  ASP A N   1 
ATOM   720  C  CA  . ASP A 1 90  ? -5.626  -29.222 20.957  1    40.78  ? 86  ASP A CA  1 
ATOM   721  C  C   . ASP A 1 90  ? -5.202  -30.602 20.45   1    41.4   ? 86  ASP A C   1 
ATOM   722  O  O   . ASP A 1 90  ? -4.743  -31.44  21.224  1    45.13  ? 86  ASP A O   1 
ATOM   723  C  CB  . ASP A 1 90  ? -4.721  -28.14  20.407  1    41.67  ? 86  ASP A CB  1 
ATOM   724  C  CG  . ASP A 1 90  ? -3.246  -28.333 20.655  1    43.94  ? 86  ASP A CG  1 
ATOM   725  O  OD1 . ASP A 1 90  ? -2.655  -29.199 20.031  1    52     ? 86  ASP A OD1 1 
ATOM   726  O  OD2 . ASP A 1 90  ? -2.698  -27.578 21.42   1    57.43  ? 86  ASP A OD2 1 
ATOM   727  N  N   . LEU A 1 91  ? -5.365  -30.84  19.144  1    36.23  ? 87  LEU A N   1 
ATOM   728  C  CA  . LEU A 1 91  ? -5.218  -32.176 18.604  1    37     ? 87  LEU A CA  1 
ATOM   729  C  C   . LEU A 1 91  ? -3.737  -32.538 18.54   1    40.9   ? 87  LEU A C   1 
ATOM   730  O  O   . LEU A 1 91  ? -3.409  -33.722 18.596  1    47.67  ? 87  LEU A O   1 
ATOM   731  C  CB  . LEU A 1 91  ? -5.863  -32.235 17.223  1    34.62  ? 87  LEU A CB  1 
ATOM   732  C  CG  . LEU A 1 91  ? -5.753  -33.571 16.478  1    34.32  ? 87  LEU A CG  1 
ATOM   733  C  CD1 . LEU A 1 91  ? -6.629  -34.648 17.109  1    32.12  ? 87  LEU A CD1 1 
ATOM   734  C  CD2 . LEU A 1 91  ? -6.119  -33.342 15.003  1    34.53  ? 87  LEU A CD2 1 
ATOM   735  N  N   . LYS A 1 92  ? -2.858  -31.535 18.396  1    39.89  ? 88  LYS A N   1 
ATOM   736  C  CA  . LYS A 1 92  ? -1.425  -31.765 18.394  1    46.08  ? 88  LYS A CA  1 
ATOM   737  C  C   . LYS A 1 92  ? -0.978  -32.398 19.718  1    51.67  ? 88  LYS A C   1 
ATOM   738  O  O   . LYS A 1 92  ? -0.353  -33.466 19.703  1    52.75  ? 88  LYS A O   1 
ATOM   739  C  CB  . LYS A 1 92  ? -0.693  -30.505 17.945  1    50.29  ? 88  LYS A CB  1 
ATOM   740  C  CG  . LYS A 1 92  ? 0.811   -30.531 17.897  1    58.42  ? 88  LYS A CG  1 
ATOM   741  C  CD  . LYS A 1 92  ? 1.363   -31.561 16.912  1    77.71  ? 88  LYS A CD  1 
ATOM   742  C  CE  . LYS A 1 92  ? 2.848   -31.573 16.655  1    81.6   ? 88  LYS A CE  1 
ATOM   743  N  NZ  . LYS A 1 92  ? 3.201   -32.755 15.858  1    74.56  ? 88  LYS A NZ  1 
ATOM   744  N  N   . LYS A 1 93  ? -1.364  -31.794 20.859  1    50.26  ? 89  LYS A N   1 
ATOM   745  C  CA  . LYS A 1 93  ? -1.015  -32.318 22.177  1    53.75  ? 89  LYS A CA  1 
ATOM   746  C  C   . LYS A 1 93  ? -1.58   -33.723 22.42   1    50.94  ? 89  LYS A C   1 
ATOM   747  O  O   . LYS A 1 93  ? -0.977  -34.501 23.148  1    57.37  ? 89  LYS A O   1 
ATOM   748  C  CB  . LYS A 1 93  ? -1.399  -31.322 23.278  1    56.65  ? 89  LYS A CB  1 
ATOM   749  C  CG  . LYS A 1 93  ? -0.615  -30.016 23.221  1    67.64  ? 89  LYS A CG  1 
ATOM   750  C  CD  . LYS A 1 93  ? -1.325  -28.861 23.923  1    85.1   ? 89  LYS A CD  1 
ATOM   751  C  CE  . LYS A 1 93  ? -0.629  -27.536 23.795  1    88.23  ? 89  LYS A CE  1 
ATOM   752  N  NZ  . LYS A 1 93  ? -0.877  -26.704 24.978  1    97.73  ? 89  LYS A NZ  1 
ATOM   753  N  N   . PHE A 1 94  ? -2.736  -34.044 21.822  1    46.82  ? 90  PHE A N   1 
ATOM   754  C  CA  . PHE A 1 94  ? -3.404  -35.321 22.025  1    45.27  ? 90  PHE A CA  1 
ATOM   755  C  C   . PHE A 1 94  ? -2.708  -36.426 21.222  1    46.12  ? 90  PHE A C   1 
ATOM   756  O  O   . PHE A 1 94  ? -2.474  -37.517 21.748  1    47.15  ? 90  PHE A O   1 
ATOM   757  C  CB  . PHE A 1 94  ? -4.904  -35.153 21.733  1    43.01  ? 90  PHE A CB  1 
ATOM   758  C  CG  . PHE A 1 94  ? -5.705  -36.445 21.71   1    45.08  ? 90  PHE A CG  1 
ATOM   759  C  CD1 . PHE A 1 94  ? -6.031  -37.12  22.902  1    47.38  ? 90  PHE A CD1 1 
ATOM   760  C  CD2 . PHE A 1 94  ? -6.105  -36.994 20.489  1    43.22  ? 90  PHE A CD2 1 
ATOM   761  C  CE1 . PHE A 1 94  ? -6.762  -38.301 22.873  1    47.38  ? 90  PHE A CE1 1 
ATOM   762  C  CE2 . PHE A 1 94  ? -6.813  -38.193 20.46   1    46.69  ? 90  PHE A CE2 1 
ATOM   763  C  CZ  . PHE A 1 94  ? -7.135  -38.835 21.651  1    46.66  ? 90  PHE A CZ  1 
ATOM   764  N  N   . MET A 1 95  ? -2.426  -36.136 19.938  1    44.35  ? 91  MET A N   1 
ATOM   765  C  CA  . MET A 1 95  ? -1.625  -37.005 19.089  1    48.91  ? 91  MET A CA  1 
ATOM   766  C  C   . MET A 1 95  ? -0.273  -37.319 19.739  1    52.46  ? 91  MET A C   1 
ATOM   767  O  O   . MET A 1 95  ? 0.209   -38.44  19.611  1    55.91  ? 91  MET A O   1 
ATOM   768  C  CB  . MET A 1 95  ? -1.375  -36.349 17.726  1    47.83  ? 91  MET A CB  1 
ATOM   769  C  CG  . MET A 1 95  ? -2.416  -36.633 16.703  1    47.3   ? 91  MET A CG  1 
ATOM   770  S  SD  . MET A 1 95  ? -2.139  -35.62  15.238  1    68.03  ? 91  MET A SD  1 
ATOM   771  C  CE  . MET A 1 95  ? -1.718  -34.022 15.917  1    55.42  ? 91  MET A CE  1 
ATOM   772  N  N   . ASP A 1 96  ? 0.34    -36.316 20.394  1    54.25  ? 92  ASP A N   1 
ATOM   773  C  CA  . ASP A 1 96  ? 1.617   -36.472 21.075  1    58.02  ? 92  ASP A CA  1 
ATOM   774  C  C   . ASP A 1 96  ? 1.438   -37.261 22.364  1    64.01  ? 92  ASP A C   1 
ATOM   775  O  O   . ASP A 1 96  ? 2.324   -38.035 22.708  1    71.3   ? 92  ASP A O   1 
ATOM   776  C  CB  . ASP A 1 96  ? 2.32    -35.155 21.363  1    55.27  ? 92  ASP A CB  1 
ATOM   777  C  CG  . ASP A 1 96  ? 2.874   -34.41  20.16   1    54.82  ? 92  ASP A CG  1 
ATOM   778  O  OD1 . ASP A 1 96  ? 2.94    -34.991 19.034  1    54.59  ? 92  ASP A OD1 1 
ATOM   779  O  OD2 . ASP A 1 96  ? 3.145   -33.222 20.336  1    56.7   ? 92  ASP A OD2 1 
ATOM   780  N  N   . ALA A 1 97  ? 0.313   -37.062 23.071  1    64.41  ? 93  ALA A N   1 
ATOM   781  C  CA  . ALA A 1 97  ? 0.005   -37.887 24.237  1    68.31  ? 93  ALA A CA  1 
ATOM   782  C  C   . ALA A 1 97  ? -0.375  -39.311 23.811  1    70.32  ? 93  ALA A C   1 
ATOM   783  O  O   . ALA A 1 97  ? -0.224  -40.225 24.628  1    64.84  ? 93  ALA A O   1 
ATOM   784  C  CB  . ALA A 1 97  ? -1.065  -37.256 25.087  1    60.63  ? 93  ALA A CB  1 
ATOM   785  N  N   . SER A 1 98  ? -0.824  -39.47  22.538  1    67.02  ? 94  SER A N   1 
ATOM   786  C  CA  . SER A 1 98  ? -1.208  -40.75  21.95   1    72.81  ? 94  SER A CA  1 
ATOM   787  C  C   . SER A 1 98  ? -0.034  -41.429 21.243  1    92.89  ? 94  SER A C   1 
ATOM   788  O  O   . SER A 1 98  ? -0.263  -42.141 20.264  1    90.62  ? 94  SER A O   1 
ATOM   789  C  CB  . SER A 1 98  ? -2.329  -40.61  20.955  1    63.48  ? 94  SER A CB  1 
ATOM   790  O  OG  . SER A 1 98  ? -3.507  -40.185 21.608  1    74.2   ? 94  SER A OG  1 
ATOM   791  N  N   . ALA A 1 99  ? 1.194   -41.247 21.756  1    112.61 ? 95  ALA A N   1 
ATOM   792  C  CA  . ALA A 1 99  ? 2.436   -41.487 21.03   1    109.2  ? 95  ALA A CA  1 
ATOM   793  C  C   . ALA A 1 99  ? 2.508   -42.907 20.473  1    107.34 ? 95  ALA A C   1 
ATOM   794  O  O   . ALA A 1 99  ? 2.633   -43.093 19.267  1    109.37 ? 95  ALA A O   1 
ATOM   795  C  CB  . ALA A 1 99  ? 3.611   -41.222 21.947  1    114.79 ? 95  ALA A CB  1 
ATOM   796  N  N   . LEU A 1 100 ? 2.423   -43.887 21.379  1    106.66 ? 96  LEU A N   1 
ATOM   797  C  CA  . LEU A 1 100 ? 2.742   -45.285 21.148  1    115.83 ? 96  LEU A CA  1 
ATOM   798  C  C   . LEU A 1 100 ? 1.465   -46.109 21.326  1    108.2  ? 96  LEU A C   1 
ATOM   799  O  O   . LEU A 1 100 ? 1.483   -47.341 21.288  1    100.1  ? 96  LEU A O   1 
ATOM   800  C  CB  . LEU A 1 100 ? 3.792   -45.609 22.222  1    137.85 ? 96  LEU A CB  1 
ATOM   801  C  CG  . LEU A 1 100 ? 5.034   -46.398 21.791  1    136.3  ? 96  LEU A CG  1 
ATOM   802  C  CD1 . LEU A 1 100 ? 5.881   -45.446 20.967  1    135.76 ? 96  LEU A CD1 1 
ATOM   803  C  CD2 . LEU A 1 100 ? 5.833   -46.944 22.964  1    121.15 ? 96  LEU A CD2 1 
ATOM   804  N  N   . THR A 1 101 ? 0.365   -45.394 21.584  1    105.41 ? 97  THR A N   1 
ATOM   805  C  CA  . THR A 1 101 ? -0.948  -45.992 21.705  1    101.3  ? 97  THR A CA  1 
ATOM   806  C  C   . THR A 1 101 ? -1.55   -46.039 20.297  1    100.67 ? 97  THR A C   1 
ATOM   807  O  O   . THR A 1 101 ? -2.115  -47.048 19.883  1    113.07 ? 97  THR A O   1 
ATOM   808  C  CB  . THR A 1 101 ? -1.792  -45.201 22.72   1    100.26 ? 97  THR A CB  1 
ATOM   809  O  OG1 . THR A 1 101 ? -2.537  -44.174 22.074  1    93.71  ? 97  THR A OG1 1 
ATOM   810  C  CG2 . THR A 1 101 ? -0.955  -44.559 23.817  1    101.18 ? 97  THR A CG2 1 
ATOM   811  N  N   . GLY A 1 102 ? -1.351  -44.959 19.532  1    80.28  ? 98  GLY A N   1 
ATOM   812  C  CA  . GLY A 1 102 ? -2.173  -44.694 18.365  1    65.08  ? 98  GLY A CA  1 
ATOM   813  C  C   . GLY A 1 102 ? -3.463  -43.996 18.785  1    59.64  ? 98  GLY A C   1 
ATOM   814  O  O   . GLY A 1 102 ? -3.802  -43.997 19.966  1    60.02  ? 98  GLY A O   1 
ATOM   815  N  N   . ILE A 1 103 ? -4.147  -43.354 17.835  1    53.25  ? 99  ILE A N   1 
ATOM   816  C  CA  . ILE A 1 103 ? -5.509  -42.903 18.076  1    49.22  ? 99  ILE A CA  1 
ATOM   817  C  C   . ILE A 1 103 ? -6.444  -43.965 17.5    1    46.87  ? 99  ILE A C   1 
ATOM   818  O  O   . ILE A 1 103 ? -6.372  -44.274 16.314  1    45.5   ? 99  ILE A O   1 
ATOM   819  C  CB  . ILE A 1 103 ? -5.767  -41.545 17.406  1    48.93  ? 99  ILE A CB  1 
ATOM   820  C  CG1 . ILE A 1 103 ? -4.766  -40.477 17.795  1    47.63  ? 99  ILE A CG1 1 
ATOM   821  C  CG2 . ILE A 1 103 ? -7.204  -41.083 17.68   1    50.04  ? 99  ILE A CG2 1 
ATOM   822  C  CD1 . ILE A 1 103 ? -5.069  -39.141 17.117  1    45.28  ? 99  ILE A CD1 1 
ATOM   823  N  N   . PRO A 1 104 ? -7.4    -44.505 18.286  1    47.5   ? 100 PRO A N   1 
ATOM   824  C  CA  . PRO A 1 104 ? -8.311  -45.544 17.78   1    48     ? 100 PRO A CA  1 
ATOM   825  C  C   . PRO A 1 104 ? -9.113  -45.03  16.584  1    46.64  ? 100 PRO A C   1 
ATOM   826  O  O   . PRO A 1 104 ? -9.482  -43.859 16.528  1    44.73  ? 100 PRO A O   1 
ATOM   827  C  CB  . PRO A 1 104 ? -9.238  -45.781 18.979  1    50.51  ? 100 PRO A CB  1 
ATOM   828  C  CG  . PRO A 1 104 ? -8.434  -45.309 20.164  1    51.76  ? 100 PRO A CG  1 
ATOM   829  C  CD  . PRO A 1 104 ? -7.74   -44.052 19.644  1    46.72  ? 100 PRO A CD  1 
ATOM   830  N  N   . LEU A 1 105 ? -9.39   -45.922 15.633  1    48.77  ? 101 LEU A N   1 
ATOM   831  C  CA  . LEU A 1 105 ? -9.967  -45.564 14.339  1    48.26  ? 101 LEU A CA  1 
ATOM   832  C  C   . LEU A 1 105 ? -11.32  -44.866 14.521  1    50.74  ? 101 LEU A C   1 
ATOM   833  O  O   . LEU A 1 105 ? -11.604 -43.907 13.797  1    46.19  ? 101 LEU A O   1 
ATOM   834  C  CB  . LEU A 1 105 ? -10.098 -46.851 13.526  1    48.31  ? 101 LEU A CB  1 
ATOM   835  C  CG  . LEU A 1 105 ? -10.751 -46.743 12.142  1    51.14  ? 101 LEU A CG  1 
ATOM   836  C  CD1 . LEU A 1 105 ? -9.869  -45.853 11.298  1    53.3   ? 101 LEU A CD1 1 
ATOM   837  C  CD2 . LEU A 1 105 ? -11.014 -48.087 11.439  1    45.27  ? 101 LEU A CD2 1 
ATOM   838  N  N   . PRO A 1 106 ? -12.179 -45.298 15.491  1    50.58  ? 102 PRO A N   1 
ATOM   839  C  CA  . PRO A 1 106 ? -13.456 -44.637 15.727  1    50.42  ? 102 PRO A CA  1 
ATOM   840  C  C   . PRO A 1 106 ? -13.253 -43.182 16.112  1    50.53  ? 102 PRO A C   1 
ATOM   841  O  O   . PRO A 1 106 ? -14.082 -42.344 15.752  1    54     ? 102 PRO A O   1 
ATOM   842  C  CB  . PRO A 1 106 ? -14.119 -45.451 16.889  1    52.42  ? 102 PRO A CB  1 
ATOM   843  C  CG  . PRO A 1 106 ? -13.414 -46.798 16.843  1    51.37  ? 102 PRO A CG  1 
ATOM   844  C  CD  . PRO A 1 106 ? -12.008 -46.472 16.379  1    50.86  ? 102 PRO A CD  1 
ATOM   845  N  N   . LEU A 1 107 ? -12.157 -42.89  16.829  1    46.25  ? 103 LEU A N   1 
ATOM   846  C  CA  . LEU A 1 107 ? -11.912 -41.524 17.238  1    44.05  ? 103 LEU A CA  1 
ATOM   847  C  C   . LEU A 1 107 ? -11.417 -40.68  16.067  1    40.09  ? 103 LEU A C   1 
ATOM   848  O  O   . LEU A 1 107 ? -11.805 -39.52  15.917  1    38.64  ? 103 LEU A O   1 
ATOM   849  C  CB  . LEU A 1 107 ? -10.982 -41.52  18.438  1    46.87  ? 103 LEU A CB  1 
ATOM   850  C  CG  . LEU A 1 107 ? -10.986 -40.224 19.256  1    52.5   ? 103 LEU A CG  1 
ATOM   851  C  CD1 . LEU A 1 107 ? -12.397 -39.878 19.761  1    50.86  ? 103 LEU A CD1 1 
ATOM   852  C  CD2 . LEU A 1 107 ? -10.035 -40.387 20.435  1    59.49  ? 103 LEU A CD2 1 
ATOM   853  N  N   . ILE A 1 108 ? -10.615 -41.278 15.183  1    43.35  ? 104 ILE A N   1 
ATOM   854  C  CA  . ILE A 1 108 ? -10.125 -40.581 13.991  1    44.07  ? 104 ILE A CA  1 
ATOM   855  C  C   . ILE A 1 108 ? -11.309 -40.2   13.086  1    41.24  ? 104 ILE A C   1 
ATOM   856  O  O   . ILE A 1 108 ? -11.444 -39.075 12.602  1    39.59  ? 104 ILE A O   1 
ATOM   857  C  CB  . ILE A 1 108 ? -9.074  -41.452 13.269  1    43.75  ? 104 ILE A CB  1 
ATOM   858  C  CG1 . ILE A 1 108 ? -7.789  -41.601 14.093  1    44.83  ? 104 ILE A CG1 1 
ATOM   859  C  CG2 . ILE A 1 108 ? -8.776  -40.899 11.878  1    44.55  ? 104 ILE A CG2 1 
ATOM   860  C  CD1 . ILE A 1 108 ? -6.791  -42.593 13.53   1    42.01  ? 104 ILE A CD1 1 
ATOM   861  N  N   . LYS A 1 109 ? -12.179 -41.174 12.872  1    41.64  ? 105 LYS A N   1 
ATOM   862  C  CA  . LYS A 1 109 ? -13.344 -41.042 12.013  1    44.42  ? 105 LYS A CA  1 
ATOM   863  C  C   . LYS A 1 109 ? -14.339 -40.006 12.555  1    41.37  ? 105 LYS A C   1 
ATOM   864  O  O   . LYS A 1 109 ? -14.825 -39.159 11.797  1    40.49  ? 105 LYS A O   1 
ATOM   865  C  CB  . LYS A 1 109 ? -13.855 -42.48  11.889  1    46.67  ? 105 LYS A CB  1 
ATOM   866  C  CG  . LYS A 1 109 ? -14.956 -42.706 10.898  1    51.05  ? 105 LYS A CG  1 
ATOM   867  C  CD  . LYS A 1 109 ? -15.293 -44.19  10.841  1    50.82  ? 105 LYS A CD  1 
ATOM   868  C  CE  . LYS A 1 109 ? -14.211 -45.045 10.316  1    48.58  ? 105 LYS A CE  1 
ATOM   869  N  NZ  . LYS A 1 109 ? -14.741 -46.348 9.858   1    49.5   ? 105 LYS A NZ  1 
ATOM   870  N  N   . SER A 1 110 ? -14.606 -40.05  13.868  1    41.69  ? 106 SER A N   1 
ATOM   871  C  CA  . SER A 1 110 ? -15.388 -39.042 14.581  1    40.26  ? 106 SER A CA  1 
ATOM   872  C  C   . SER A 1 110 ? -14.775 -37.652 14.429  1    39.28  ? 106 SER A C   1 
ATOM   873  O  O   . SER A 1 110 ? -15.496 -36.691 14.108  1    39.76  ? 106 SER A O   1 
ATOM   874  C  CB  . SER A 1 110 ? -15.555 -39.371 16.035  1    40.6   ? 106 SER A CB  1 
ATOM   875  O  OG  . SER A 1 110 ? -16.102 -38.259 16.747  1    40.65  ? 106 SER A OG  1 
ATOM   876  N  N   . TYR A 1 111 ? -13.456 -37.543 14.661  1    37.24  ? 107 TYR A N   1 
ATOM   877  C  CA  . TYR A 1 111 ? -12.814 -36.235 14.543  1    38.01  ? 107 TYR A CA  1 
ATOM   878  C  C   . TYR A 1 111 ? -12.875 -35.713 13.099  1    39.19  ? 107 TYR A C   1 
ATOM   879  O  O   . TYR A 1 111 ? -13.225 -34.545 12.88   1    40.78  ? 107 TYR A O   1 
ATOM   880  C  CB  . TYR A 1 111 ? -11.39  -36.24  15.094  1    37.37  ? 107 TYR A CB  1 
ATOM   881  C  CG  . TYR A 1 111 ? -11.263 -36.223 16.614  1    39.6   ? 107 TYR A CG  1 
ATOM   882  C  CD1 . TYR A 1 111 ? -12.368 -36.009 17.441  1    38.93  ? 107 TYR A CD1 1 
ATOM   883  C  CD2 . TYR A 1 111 ? -10.023 -36.4   17.22   1    37.46  ? 107 TYR A CD2 1 
ATOM   884  C  CE1 . TYR A 1 111 ? -12.238 -35.993 18.822  1    42.03  ? 107 TYR A CE1 1 
ATOM   885  C  CE2 . TYR A 1 111 ? -9.879  -36.362 18.597  1    41.57  ? 107 TYR A CE2 1 
ATOM   886  C  CZ  . TYR A 1 111 ? -10.989 -36.171 19.398  1    42.01  ? 107 TYR A CZ  1 
ATOM   887  O  OH  . TYR A 1 111 ? -10.878 -36.11  20.748  1    44.05  ? 107 TYR A OH  1 
ATOM   888  N  N   . LEU A 1 112 ? -12.571 -36.582 12.107  1    37.27  ? 108 LEU A N   1 
ATOM   889  C  CA  . LEU A 1 112 ? -12.59  -36.12  10.725  1    36.88  ? 108 LEU A CA  1 
ATOM   890  C  C   . LEU A 1 112 ? -14.023 -35.712 10.302  1    38.01  ? 108 LEU A C   1 
ATOM   891  O  O   . LEU A 1 112 ? -14.23  -34.659 9.676   1    34.2   ? 108 LEU A O   1 
ATOM   892  C  CB  . LEU A 1 112 ? -11.97  -37.176 9.818   1    32.93  ? 108 LEU A CB  1 
ATOM   893  C  CG  . LEU A 1 112 ? -11.83  -36.725 8.363   1    33.97  ? 108 LEU A CG  1 
ATOM   894  C  CD1 . LEU A 1 112 ? -10.894 -35.519 8.283   1    31.56  ? 108 LEU A CD1 1 
ATOM   895  C  CD2 . LEU A 1 112 ? -11.331 -37.821 7.463   1    32.35  ? 108 LEU A CD2 1 
ATOM   896  N  N   . PHE A 1 113 ? -15.032 -36.522 10.69   1    37.22  ? 109 PHE A N   1 
ATOM   897  C  CA  . PHE A 1 113 ? -16.422 -36.193 10.391  1    36.77  ? 109 PHE A CA  1 
ATOM   898  C  C   . PHE A 1 113 ? -16.822 -34.826 10.956  1    37.05  ? 109 PHE A C   1 
ATOM   899  O  O   . PHE A 1 113 ? -17.413 -34.012 10.239  1    36.89  ? 109 PHE A O   1 
ATOM   900  C  CB  . PHE A 1 113 ? -17.335 -37.228 11.021  1    36.37  ? 109 PHE A CB  1 
ATOM   901  C  CG  . PHE A 1 113 ? -18.716 -37.275 10.4    1    36.15  ? 109 PHE A CG  1 
ATOM   902  C  CD1 . PHE A 1 113 ? -18.875 -37.488 9.042   1    34.92  ? 109 PHE A CD1 1 
ATOM   903  C  CD2 . PHE A 1 113 ? -19.844 -37.125 11.191  1    38.64  ? 109 PHE A CD2 1 
ATOM   904  C  CE1 . PHE A 1 113 ? -20.139 -37.561 8.492   1    37.49  ? 109 PHE A CE1 1 
ATOM   905  C  CE2 . PHE A 1 113 ? -21.125 -37.22  10.641  1    41.25  ? 109 PHE A CE2 1 
ATOM   906  C  CZ  . PHE A 1 113 ? -21.27  -37.445 9.289   1    38.37  ? 109 PHE A CZ  1 
ATOM   907  N  N   . GLN A 1 114 ? -16.446 -34.546 12.218  1    36.73  ? 110 GLN A N   1 
ATOM   908  C  CA  . GLN A 1 114 ? -16.795 -33.278 12.846  1    34.76  ? 110 GLN A CA  1 
ATOM   909  C  C   . GLN A 1 114 ? -16.03  -32.123 12.201  1    37.56  ? 110 GLN A C   1 
ATOM   910  O  O   . GLN A 1 114 ? -16.576 -31.028 12.034  1    33.22  ? 110 GLN A O   1 
ATOM   911  C  CB  . GLN A 1 114 ? -16.489 -33.331 14.338  1    33.39  ? 110 GLN A CB  1 
ATOM   912  C  CG  . GLN A 1 114 ? -17.304 -34.338 15.117  1    32.11  ? 110 GLN A CG  1 
ATOM   913  C  CD  . GLN A 1 114 ? -16.946 -34.283 16.587  1    37.22  ? 110 GLN A CD  1 
ATOM   914  O  OE1 . GLN A 1 114 ? -17.127 -33.253 17.246  1    39.06  ? 110 GLN A OE1 1 
ATOM   915  N  NE2 . GLN A 1 114 ? -16.398 -35.373 17.117  1    36.26  ? 110 GLN A NE2 1 
ATOM   916  N  N   . LEU A 1 115 ? -14.751 -32.365 11.857  1    35.53  ? 111 LEU A N   1 
ATOM   917  C  CA  . LEU A 1 115 ? -13.966 -31.322 11.221  1    33.81  ? 111 LEU A CA  1 
ATOM   918  C  C   . LEU A 1 115 ? -14.639 -30.923 9.911   1    30.58  ? 111 LEU A C   1 
ATOM   919  O  O   . LEU A 1 115 ? -14.789 -29.748 9.604   1    29.2   ? 111 LEU A O   1 
ATOM   920  C  CB  . LEU A 1 115 ? -12.538 -31.833 10.983  1    33.36  ? 111 LEU A CB  1 
ATOM   921  C  CG  . LEU A 1 115 ? -11.684 -31.923 12.249  1    34.73  ? 111 LEU A CG  1 
ATOM   922  C  CD1 . LEU A 1 115 ? -10.348 -32.606 11.99   1    29.25  ? 111 LEU A CD1 1 
ATOM   923  C  CD2 . LEU A 1 115 ? -11.512 -30.507 12.86   1    30.54  ? 111 LEU A CD2 1 
ATOM   924  N  N   . LEU A 1 116 ? -15.031 -31.922 9.123   1    30.05  ? 112 LEU A N   1 
ATOM   925  C  CA  . LEU A 1 116 ? -15.661 -31.632 7.847   1    32.96  ? 112 LEU A CA  1 
ATOM   926  C  C   . LEU A 1 116 ? -16.986 -30.886 8.039   1    36.27  ? 112 LEU A C   1 
ATOM   927  O  O   . LEU A 1 116 ? -17.332 -30.067 7.182   1    35.73  ? 112 LEU A O   1 
ATOM   928  C  CB  . LEU A 1 116 ? -15.884 -32.947 7.114   1    33.23  ? 112 LEU A CB  1 
ATOM   929  C  CG  . LEU A 1 116 ? -14.608 -33.602 6.597   1    34     ? 112 LEU A CG  1 
ATOM   930  C  CD1 . LEU A 1 116 ? -14.848 -35.088 6.342   1    32.61  ? 112 LEU A CD1 1 
ATOM   931  C  CD2 . LEU A 1 116 ? -14.188 -32.85  5.34    1    33.53  ? 112 LEU A CD2 1 
ATOM   932  N  N   . GLN A 1 117 ? -17.727 -31.183 9.129   1    33.15  ? 113 GLN A N   1 
ATOM   933  C  CA  . GLN A 1 117 ? -18.972 -30.481 9.408   1    35.04  ? 113 GLN A CA  1 
ATOM   934  C  C   . GLN A 1 117 ? -18.709 -28.996 9.614   1    33.76  ? 113 GLN A C   1 
ATOM   935  O  O   . GLN A 1 117 ? -19.399 -28.164 9.033   1    36.25  ? 113 GLN A O   1 
ATOM   936  C  CB  . GLN A 1 117 ? -19.652 -31.002 10.673  1    34.98  ? 113 GLN A CB  1 
ATOM   937  C  CG  . GLN A 1 117 ? -20.35  -32.332 10.448  1    36.43  ? 113 GLN A CG  1 
ATOM   938  C  CD  . GLN A 1 117 ? -21.164 -32.74  11.65   1    37.65  ? 113 GLN A CD  1 
ATOM   939  O  OE1 . GLN A 1 117 ? -22.135 -32.077 12.055  1    39.63  ? 113 GLN A OE1 1 
ATOM   940  N  NE2 . GLN A 1 117 ? -20.746 -33.84  12.239  1    35.88  ? 113 GLN A NE2 1 
ATOM   941  N  N   . GLY A 1 118 ? -17.685 -28.69  10.426  1    33.23  ? 114 GLY A N   1 
ATOM   942  C  CA  . GLY A 1 118 ? -17.354 -27.326 10.793  1    31.43  ? 114 GLY A CA  1 
ATOM   943  C  C   . GLY A 1 118 ? -16.859 -26.565 9.575   1    32.35  ? 114 GLY A C   1 
ATOM   944  O  O   . GLY A 1 118 ? -17.171 -25.384 9.375   1    32.89  ? 114 GLY A O   1 
ATOM   945  N  N   . LEU A 1 119 ? -16.109 -27.287 8.747   1    33.5   ? 115 LEU A N   1 
ATOM   946  C  CA  . LEU A 1 119 ? -15.506 -26.679 7.582   1    33     ? 115 LEU A CA  1 
ATOM   947  C  C   . LEU A 1 119 ? -16.592 -26.382 6.563   1    33.82  ? 115 LEU A C   1 
ATOM   948  O  O   . LEU A 1 119 ? -16.572 -25.299 5.959   1    37.08  ? 115 LEU A O   1 
ATOM   949  C  CB  . LEU A 1 119 ? -14.405 -27.549 6.986   1    31.2   ? 115 LEU A CB  1 
ATOM   950  C  CG  . LEU A 1 119 ? -13.675 -26.897 5.806   1    36.58  ? 115 LEU A CG  1 
ATOM   951  C  CD1 . LEU A 1 119 ? -13.007 -25.551 6.238   1    35.15  ? 115 LEU A CD1 1 
ATOM   952  C  CD2 . LEU A 1 119 ? -12.62  -27.848 5.262   1    33.71  ? 115 LEU A CD2 1 
ATOM   953  N  N   . ALA A 1 120 ? -17.514 -27.343 6.357   1    32.02  ? 116 ALA A N   1 
ATOM   954  C  CA  . ALA A 1 120 ? -18.605 -27.123 5.391   1    32.72  ? 116 ALA A CA  1 
ATOM   955  C  C   . ALA A 1 120 ? -19.407 -25.888 5.803   1    32.46  ? 116 ALA A C   1 
ATOM   956  O  O   . ALA A 1 120 ? -19.792 -25.079 4.961   1    36.56  ? 116 ALA A O   1 
ATOM   957  C  CB  . ALA A 1 120 ? -19.513 -28.342 5.304   1    31.98  ? 116 ALA A CB  1 
ATOM   958  N  N   . PHE A 1 121 ? -19.658 -25.767 7.111   1    29.25  ? 117 PHE A N   1 
ATOM   959  C  CA  . PHE A 1 121 ? -20.38  -24.635 7.653   1    31.55  ? 117 PHE A CA  1 
ATOM   960  C  C   . PHE A 1 121 ? -19.627 -23.333 7.334   1    33.8   ? 117 PHE A C   1 
ATOM   961  O  O   . PHE A 1 121 ? -20.259 -22.371 6.89    1    37.18  ? 117 PHE A O   1 
ATOM   962  C  CB  . PHE A 1 121 ? -20.66  -24.881 9.15    1    29.55  ? 117 PHE A CB  1 
ATOM   963  C  CG  . PHE A 1 121 ? -21.574 -23.814 9.736   1    34.51  ? 117 PHE A CG  1 
ATOM   964  C  CD1 . PHE A 1 121 ? -21.072 -22.558 10.123  1    32.66  ? 117 PHE A CD1 1 
ATOM   965  C  CD2 . PHE A 1 121 ? -22.963 -24.026 9.825   1    32.6   ? 117 PHE A CD2 1 
ATOM   966  C  CE1 . PHE A 1 121 ? -21.927 -21.575 10.626  1    34.29  ? 117 PHE A CE1 1 
ATOM   967  C  CE2 . PHE A 1 121 ? -23.803 -23.039 10.343  1    31.99  ? 117 PHE A CE2 1 
ATOM   968  C  CZ  . PHE A 1 121 ? -23.295 -21.808 10.741  1    31.39  ? 117 PHE A CZ  1 
ATOM   969  N  N   . CYS A 1 122 ? -18.287 -23.299 7.523   1    31.34  ? 118 CYS A N   1 
ATOM   970  C  CA  . CYS A 1 122 ? -17.504 -22.139 7.111   1    31.85  ? 118 CYS A CA  1 
ATOM   971  C  C   . CYS A 1 122 ? -17.7   -21.825 5.63    1    31.3   ? 118 CYS A C   1 
ATOM   972  O  O   . CYS A 1 122 ? -17.973 -20.688 5.247   1    33.54  ? 118 CYS A O   1 
ATOM   973  C  CB  . CYS A 1 122 ? -16.006 -22.321 7.338   1    31.39  ? 118 CYS A CB  1 
ATOM   974  S  SG  . CYS A 1 122 ? -15.574 -22.375 9.096   1    36.14  ? 118 CYS A SG  1 
ATOM   975  N  N   . HIS A 1 123 ? -17.511 -22.826 4.777   1    32.13  ? 119 HIS A N   1 
ATOM   976  C  CA  . HIS A 1 123 ? -17.564 -22.572 3.347   1    33.69  ? 119 HIS A CA  1 
ATOM   977  C  C   . HIS A 1 123 ? -18.963 -22.117 2.914   1    35.64  ? 119 HIS A C   1 
ATOM   978  O  O   . HIS A 1 123 ? -19.082 -21.316 1.981   1    37.11  ? 119 HIS A O   1 
ATOM   979  C  CB  . HIS A 1 123 ? -17.064 -23.806 2.591   1    31.28  ? 119 HIS A CB  1 
ATOM   980  C  CG  . HIS A 1 123 ? -15.626 -24.062 2.853   1    35.21  ? 119 HIS A CG  1 
ATOM   981  N  ND1 . HIS A 1 123 ? -14.972 -25.216 2.448   1    32.54  ? 119 HIS A ND1 1 
ATOM   982  C  CD2 . HIS A 1 123 ? -14.702 -23.264 3.456   1    31.1   ? 119 HIS A CD2 1 
ATOM   983  C  CE1 . HIS A 1 123 ? -13.707 -25.125 2.843   1    33.89  ? 119 HIS A CE1 1 
ATOM   984  N  NE2 . HIS A 1 123 ? -13.519 -23.95  3.446   1    31.64  ? 119 HIS A NE2 1 
ATOM   985  N  N   . SER A 1 124 ? -20.008 -22.653 3.558   1    30.75  ? 120 SER A N   1 
ATOM   986  C  CA  . SER A 1 124 ? -21.364 -22.225 3.256   1    37.96  ? 120 SER A CA  1 
ATOM   987  C  C   . SER A 1 124 ? -21.641 -20.802 3.742   1    37.78  ? 120 SER A C   1 
ATOM   988  O  O   . SER A 1 124 ? -22.667 -20.237 3.391   1    36.41  ? 120 SER A O   1 
ATOM   989  C  CB  . SER A 1 124 ? -22.395 -23.166 3.83    1    35.53  ? 120 SER A CB  1 
ATOM   990  O  OG  . SER A 1 124 ? -22.282 -24.417 3.194   1    36.76  ? 120 SER A OG  1 
ATOM   991  N  N   . HIS A 1 125 ? -20.751 -20.258 4.579   1    34.14  ? 121 HIS A N   1 
ATOM   992  C  CA  . HIS A 1 125 ? -20.89  -18.899 5.053   1    35.75  ? 121 HIS A CA  1 
ATOM   993  C  C   . HIS A 1 125 ? -19.78  -18.023 4.479   1    37.72  ? 121 HIS A C   1 
ATOM   994  O  O   . HIS A 1 125 ? -19.408 -17.018 5.089   1    38.46  ? 121 HIS A O   1 
ATOM   995  C  CB  . HIS A 1 125 ? -20.926 -18.897 6.574   1    33.09  ? 121 HIS A CB  1 
ATOM   996  C  CG  . HIS A 1 125 ? -22.163 -19.548 7.014   1    37.68  ? 121 HIS A CG  1 
ATOM   997  N  ND1 . HIS A 1 125 ? -22.324 -20.911 6.959   1    38.71  ? 121 HIS A ND1 1 
ATOM   998  C  CD2 . HIS A 1 125 ? -23.317 -19.047 7.476   1    41.13  ? 121 HIS A CD2 1 
ATOM   999  C  CE1 . HIS A 1 125 ? -23.546 -21.214 7.388   1    38.55  ? 121 HIS A CE1 1 
ATOM   1000 N  NE2 . HIS A 1 125 ? -24.143 -20.109 7.729   1    39.36  ? 121 HIS A NE2 1 
ATOM   1001 N  N   . ARG A 1 126 ? -19.291 -18.414 3.299   1    33.23  ? 122 ARG A N   1 
ATOM   1002 C  CA  . ARG A 1 126 ? -18.252 -17.703 2.568   1    32.42  ? 122 ARG A CA  1 
ATOM   1003 C  C   . ARG A 1 126 ? -17.045 -17.35  3.457   1    31.5   ? 122 ARG A C   1 
ATOM   1004 O  O   . ARG A 1 126 ? -16.483 -16.267 3.331   1    33.85  ? 122 ARG A O   1 
ATOM   1005 C  CB  . ARG A 1 126 ? -18.927 -16.532 1.838   1    32.59  ? 122 ARG A CB  1 
ATOM   1006 C  CG  . ARG A 1 126 ? -19.664 -15.568 2.766   1    31.53  ? 122 ARG A CG  1 
ATOM   1007 C  CD  . ARG A 1 126 ? -18.869 -14.354 3.125   1    31.56  ? 122 ARG A CD  1 
ATOM   1008 N  NE  . ARG A 1 126 ? -19.74  -13.392 3.808   1    38.21  ? 122 ARG A NE  1 
ATOM   1009 C  CZ  . ARG A 1 126 ? -20.082 -13.422 5.119   1    35.88  ? 122 ARG A CZ  1 
ATOM   1010 N  NH1 . ARG A 1 126 ? -19.828 -14.468 5.881   1    33.27  ? 122 ARG A NH1 1 
ATOM   1011 N  NH2 . ARG A 1 126 ? -20.652 -12.367 5.667   1    34.9   ? 122 ARG A NH2 1 
ATOM   1012 N  N   . VAL A 1 127 ? -16.602 -18.271 4.319   1    30.18  ? 123 VAL A N   1 
ATOM   1013 C  CA  . VAL A 1 127 ? -15.408 -18.087 5.126   1    30.31  ? 123 VAL A CA  1 
ATOM   1014 C  C   . VAL A 1 127 ? -14.385 -19.17  4.774   1    32.16  ? 123 VAL A C   1 
ATOM   1015 O  O   . VAL A 1 127 ? -14.716 -20.344 4.865   1    33.32  ? 123 VAL A O   1 
ATOM   1016 C  CB  . VAL A 1 127 ? -15.701 -18.121 6.642   1    29     ? 123 VAL A CB  1 
ATOM   1017 C  CG1 . VAL A 1 127 ? -14.38  -18.192 7.464   1    26.59  ? 123 VAL A CG1 1 
ATOM   1018 C  CG2 . VAL A 1 127 ? -16.586 -16.955 7.074   1    23.87  ? 123 VAL A CG2 1 
ATOM   1019 N  N   . LEU A 1 128 ? -13.153 -18.773 4.4     1    31.07  ? 124 LEU A N   1 
ATOM   1020 C  CA  . LEU A 1 128 ? -12.017 -19.676 4.277   1    29.61  ? 124 LEU A CA  1 
ATOM   1021 C  C   . LEU A 1 128 ? -11.256 -19.61  5.591   1    31.32  ? 124 LEU A C   1 
ATOM   1022 O  O   . LEU A 1 128 ? -11.08  -18.52  6.132   1    37.66  ? 124 LEU A O   1 
ATOM   1023 C  CB  . LEU A 1 128 ? -11.079 -19.258 3.138   1    30.2   ? 124 LEU A CB  1 
ATOM   1024 C  CG  . LEU A 1 128 ? -11.619 -19.322 1.706   1    31.53  ? 124 LEU A CG  1 
ATOM   1025 C  CD1 . LEU A 1 128 ? -10.593 -18.935 0.666   1    34.04  ? 124 LEU A CD1 1 
ATOM   1026 C  CD2 . LEU A 1 128 ? -12.1   -20.68  1.345   1    30.99  ? 124 LEU A CD2 1 
ATOM   1027 N  N   . HIS A 1 129 ? -10.767 -20.748 6.075   1    30.78  ? 125 HIS A N   1 
ATOM   1028 C  CA  . HIS A 1 129 ? -10.052 -20.766 7.34    1    32.17  ? 125 HIS A CA  1 
ATOM   1029 C  C   . HIS A 1 129 ? -8.577  -20.387 7.161   1    33.5   ? 125 HIS A C   1 
ATOM   1030 O  O   . HIS A 1 129 ? -8.066  -19.472 7.83    1    31.41  ? 125 HIS A O   1 
ATOM   1031 C  CB  . HIS A 1 129 ? -10.221 -22.11  8.042   1    28.49  ? 125 HIS A CB  1 
ATOM   1032 C  CG  . HIS A 1 129 ? -9.64   -22.078 9.4     1    33.34  ? 125 HIS A CG  1 
ATOM   1033 N  ND1 . HIS A 1 129 ? -8.28   -22.152 9.574   1    32.77  ? 125 HIS A ND1 1 
ATOM   1034 C  CD2 . HIS A 1 129 ? -10.173 -21.952 10.646  1    37.15  ? 125 HIS A CD2 1 
ATOM   1035 C  CE1 . HIS A 1 129 ? -8.01   -22.091 10.89   1    36.74  ? 125 HIS A CE1 1 
ATOM   1036 N  NE2 . HIS A 1 129 ? -9.133  -21.988 11.568  1    34.92  ? 125 HIS A NE2 1 
ATOM   1037 N  N   . ARG A 1 130 ? -7.907  -21.159 6.299   1    30.44  ? 126 ARG A N   1 
ATOM   1038 C  CA  . ARG A 1 130 ? -6.6    -20.835 5.751   1    33.29  ? 126 ARG A CA  1 
ATOM   1039 C  C   . ARG A 1 130 ? -5.498  -21.043 6.794   1    34.85  ? 126 ARG A C   1 
ATOM   1040 O  O   . ARG A 1 130 ? -4.402  -20.527 6.633   1    37.07  ? 126 ARG A O   1 
ATOM   1041 C  CB  . ARG A 1 130 ? -6.555  -19.396 5.215   1    31.72  ? 126 ARG A CB  1 
ATOM   1042 C  CG  . ARG A 1 130 ? -7.511  -19.127 4.056   1    32.1   ? 126 ARG A CG  1 
ATOM   1043 C  CD  . ARG A 1 130 ? -7.201  -17.828 3.328   1    32.68  ? 126 ARG A CD  1 
ATOM   1044 N  NE  . ARG A 1 130 ? -7.113  -16.715 4.284   1    33.5   ? 126 ARG A NE  1 
ATOM   1045 C  CZ  . ARG A 1 130 ? -6.74   -15.481 3.947   1    35.11  ? 126 ARG A CZ  1 
ATOM   1046 N  NH1 . ARG A 1 130 ? -6.39   -15.19  2.701   1    32.69  ? 126 ARG A NH1 1 
ATOM   1047 N  NH2 . ARG A 1 130 ? -6.708  -14.531 4.861   1    32.3   ? 126 ARG A NH2 1 
ATOM   1048 N  N   . ASP A 1 131 ? -5.766  -21.809 7.86    1    33.73  ? 127 ASP A N   1 
ATOM   1049 C  CA  . ASP A 1 131 ? -4.722  -22.242 8.769   1    31.23  ? 127 ASP A CA  1 
ATOM   1050 C  C   . ASP A 1 131 ? -5.162  -23.481 9.538   1    34.32  ? 127 ASP A C   1 
ATOM   1051 O  O   . ASP A 1 131 ? -4.956  -23.535 10.757  1    36.09  ? 127 ASP A O   1 
ATOM   1052 C  CB  . ASP A 1 131 ? -4.358  -21.165 9.765   1    32.75  ? 127 ASP A CB  1 
ATOM   1053 C  CG  . ASP A 1 131 ? -2.956  -21.307 10.337  1    37.04  ? 127 ASP A CG  1 
ATOM   1054 O  OD1 . ASP A 1 131 ? -2.184  -22.137 9.812   1    37.81  ? 127 ASP A OD1 1 
ATOM   1055 O  OD2 . ASP A 1 131 ? -2.652  -20.574 11.287  1    41.01  ? 127 ASP A OD2 1 
ATOM   1056 N  N   . LEU A 1 132 ? -5.771  -24.464 8.832   1    32.8   ? 128 LEU A N   1 
ATOM   1057 C  CA  . LEU A 1 132 ? -6.083  -25.713 9.503   1    35.58  ? 128 LEU A CA  1 
ATOM   1058 C  C   . LEU A 1 132 ? -4.793  -26.518 9.684   1    38.61  ? 128 LEU A C   1 
ATOM   1059 O  O   . LEU A 1 132 ? -4.015  -26.73  8.742   1    37.33  ? 128 LEU A O   1 
ATOM   1060 C  CB  . LEU A 1 132 ? -7.121  -26.475 8.697   1    34.71  ? 128 LEU A CB  1 
ATOM   1061 C  CG  . LEU A 1 132 ? -8.442  -25.737 8.488   1    34.49  ? 128 LEU A CG  1 
ATOM   1062 C  CD1 . LEU A 1 132 ? -9.281  -26.461 7.465   1    30.25  ? 128 LEU A CD1 1 
ATOM   1063 C  CD2 . LEU A 1 132 ? -9.166  -25.604 9.816   1    33.7   ? 128 LEU A CD2 1 
ATOM   1064 N  N   . LYS A 1 133 ? -4.569  -26.888 10.941  1    34.99  ? 129 LYS A N   1 
ATOM   1065 C  CA  . LYS A 1 133 ? -3.47   -27.706 11.405  1    34.92  ? 129 LYS A CA  1 
ATOM   1066 C  C   . LYS A 1 133 ? -3.85   -28.153 12.815  1    37.75  ? 129 LYS A C   1 
ATOM   1067 O  O   . LYS A 1 133 ? -4.69   -27.51  13.455  1    39.07  ? 129 LYS A O   1 
ATOM   1068 C  CB  . LYS A 1 133 ? -2.16   -26.916 11.392  1    32.12  ? 129 LYS A CB  1 
ATOM   1069 C  CG  . LYS A 1 133 ? -2.179  -25.669 12.257  1    31.06  ? 129 LYS A CG  1 
ATOM   1070 C  CD  . LYS A 1 133 ? -0.848  -24.942 12.252  1    34.49  ? 129 LYS A CD  1 
ATOM   1071 C  CE  . LYS A 1 133 ? -0.862  -23.596 12.93   1    35.34  ? 129 LYS A CE  1 
ATOM   1072 N  NZ  . LYS A 1 133 ? 0.508   -23.049 12.974  1    37.59  ? 129 LYS A NZ  1 
ATOM   1073 N  N   . PRO A 1 134 ? -3.269  -29.263 13.324  1    36.2   ? 130 PRO A N   1 
ATOM   1074 C  CA  . PRO A 1 134 ? -3.697  -29.862 14.592  1    35.64  ? 130 PRO A CA  1 
ATOM   1075 C  C   . PRO A 1 134 ? -3.669  -28.918 15.791  1    41.7   ? 130 PRO A C   1 
ATOM   1076 O  O   . PRO A 1 134 ? -4.532  -29.023 16.674  1    39.77  ? 130 PRO A O   1 
ATOM   1077 C  CB  . PRO A 1 134 ? -2.714  -31.012 14.791  1    33.39  ? 130 PRO A CB  1 
ATOM   1078 C  CG  . PRO A 1 134 ? -2.22   -31.334 13.402  1    33.16  ? 130 PRO A CG  1 
ATOM   1079 C  CD  . PRO A 1 134 ? -2.178  -30.003 12.671  1    35.14  ? 130 PRO A CD  1 
ATOM   1080 N  N   . GLN A 1 135 ? -2.655  -28.032 15.829  1    38.97  ? 131 GLN A N   1 
ATOM   1081 C  CA  . GLN A 1 135 ? -2.535  -27.011 16.867  1    40.35  ? 131 GLN A CA  1 
ATOM   1082 C  C   . GLN A 1 135 ? -3.782  -26.117 16.96   1    39.45  ? 131 GLN A C   1 
ATOM   1083 O  O   . GLN A 1 135 ? -4.061  -25.565 18.005  1    43.25  ? 131 GLN A O   1 
ATOM   1084 C  CB  . GLN A 1 135 ? -1.338  -26.104 16.589  1    44.36  ? 131 GLN A CB  1 
ATOM   1085 C  CG  . GLN A 1 135 ? 0.034   -26.785 16.623  1    51.63  ? 131 GLN A CG  1 
ATOM   1086 C  CD  . GLN A 1 135 ? 0.45    -27.606 15.4    1    52.01  ? 131 GLN A CD  1 
ATOM   1087 O  OE1 . GLN A 1 135 ? -0.27   -27.834 14.417  1    45.31  ? 131 GLN A OE1 1 
ATOM   1088 N  NE2 . GLN A 1 135 ? 1.657   -28.134 15.479  1    58.46  ? 131 GLN A NE2 1 
ATOM   1089 N  N   . ASN A 1 136 ? -4.518  -25.92  15.863  1    38.26  ? 132 ASN A N   1 
ATOM   1090 C  CA  . ASN A 1 136 ? -5.622  -24.971 15.828  1    36.29  ? 132 ASN A CA  1 
ATOM   1091 C  C   . ASN A 1 136 ? -6.966  -25.717 15.881  1    36.73  ? 132 ASN A C   1 
ATOM   1092 O  O   . ASN A 1 136 ? -7.991  -25.145 15.531  1    39.47  ? 132 ASN A O   1 
ATOM   1093 C  CB  . ASN A 1 136 ? -5.565  -24.149 14.536  1    34.84  ? 132 ASN A CB  1 
ATOM   1094 C  CG  . ASN A 1 136 ? -4.442  -23.145 14.509  1    35.89  ? 132 ASN A CG  1 
ATOM   1095 O  OD1 . ASN A 1 136 ? -3.841  -22.844 15.54   1    41.26  ? 132 ASN A OD1 1 
ATOM   1096 N  ND2 . ASN A 1 136 ? -4.13   -22.581 13.354  1    34.52  ? 132 ASN A ND2 1 
ATOM   1097 N  N   . LEU A 1 137 ? -6.958  -27.016 16.244  1    36.42  ? 133 LEU A N   1 
ATOM   1098 C  CA  . LEU A 1 137 ? -8.161  -27.811 16.393  1    33.37  ? 133 LEU A CA  1 
ATOM   1099 C  C   . LEU A 1 137 ? -8.32   -28.179 17.877  1    36.84  ? 133 LEU A C   1 
ATOM   1100 O  O   . LEU A 1 137 ? -7.423  -28.766 18.474  1    36.2   ? 133 LEU A O   1 
ATOM   1101 C  CB  . LEU A 1 137 ? -8.036  -29.018 15.467  1    32.63  ? 133 LEU A CB  1 
ATOM   1102 C  CG  . LEU A 1 137 ? -7.782  -28.717 13.979  1    33.93  ? 133 LEU A CG  1 
ATOM   1103 C  CD1 . LEU A 1 137 ? -7.869  -29.978 13.122  1    31.18  ? 133 LEU A CD1 1 
ATOM   1104 C  CD2 . LEU A 1 137 ? -8.736  -27.684 13.418  1    31.71  ? 133 LEU A CD2 1 
ATOM   1105 N  N   . LEU A 1 138 ? -9.431  -27.772 18.512  1    35.82  ? 134 LEU A N   1 
ATOM   1106 C  CA  . LEU A 1 138 ? -9.595  -27.97  19.945  1    37.39  ? 134 LEU A CA  1 
ATOM   1107 C  C   . LEU A 1 138 ? -10.493 -29.17  20.262  1    37.32  ? 134 LEU A C   1 
ATOM   1108 O  O   . LEU A 1 138 ? -11.508 -29.366 19.618  1    42.9   ? 134 LEU A O   1 
ATOM   1109 C  CB  . LEU A 1 138 ? -10.132 -26.674 20.538  1    37.46  ? 134 LEU A CB  1 
ATOM   1110 C  CG  . LEU A 1 138 ? -9.223  -25.457 20.369  1    42.72  ? 134 LEU A CG  1 
ATOM   1111 C  CD1 . LEU A 1 138 ? -9.916  -24.207 20.892  1    42.9   ? 134 LEU A CD1 1 
ATOM   1112 C  CD2 . LEU A 1 138 ? -7.851  -25.618 21.032  1    42.33  ? 134 LEU A CD2 1 
ATOM   1113 N  N   . ILE A 1 139 ? -10.127 -29.966 21.26   1    36.55  ? 135 ILE A N   1 
ATOM   1114 C  CA  . ILE A 1 139 ? -10.914 -31.125 21.632  1    38.96  ? 135 ILE A CA  1 
ATOM   1115 C  C   . ILE A 1 139 ? -11.39  -30.944 23.07   1    40.34  ? 135 ILE A C   1 
ATOM   1116 O  O   . ILE A 1 139 ? -10.724 -30.295 23.857  1    40.5   ? 135 ILE A O   1 
ATOM   1117 C  CB  . ILE A 1 139 ? -10.117 -32.437 21.456  1    36.89  ? 135 ILE A CB  1 
ATOM   1118 C  CG1 . ILE A 1 139 ? -8.903  -32.49  22.374  1    42.86  ? 135 ILE A CG1 1 
ATOM   1119 C  CG2 . ILE A 1 139 ? -9.695  -32.634 20.01   1    33.49  ? 135 ILE A CG2 1 
ATOM   1120 C  CD1 . ILE A 1 139 ? -8.129  -33.797 22.297  1    43.15  ? 135 ILE A CD1 1 
ATOM   1121 N  N   . ASN A 1 140 ? -12.534 -31.54  23.418  1    42.88  ? 136 ASN A N   1 
ATOM   1122 C  CA  . ASN A 1 140 ? -13.015 -31.47  24.789  1    44.17  ? 136 ASN A CA  1 
ATOM   1123 C  C   . ASN A 1 140 ? -13.11  -32.879 25.344  1    47.44  ? 136 ASN A C   1 
ATOM   1124 O  O   . ASN A 1 140 ? -12.729 -33.844 24.687  1    53.12  ? 136 ASN A O   1 
ATOM   1125 C  CB  . ASN A 1 140 ? -14.299 -30.651 24.946  1    42.23  ? 136 ASN A CB  1 
ATOM   1126 C  CG  . ASN A 1 140 ? -15.522 -31.259 24.312  1    44.39  ? 136 ASN A CG  1 
ATOM   1127 O  OD1 . ASN A 1 140 ? -15.552 -32.455 23.955  1    46.77  ? 136 ASN A OD1 1 
ATOM   1128 N  ND2 . ASN A 1 140 ? -16.525 -30.411 24.136  1    44.77  ? 136 ASN A ND2 1 
ATOM   1129 N  N   . THR A 1 141 ? -13.589 -32.972 26.576  1    46.81  ? 137 THR A N   1 
ATOM   1130 C  CA  . THR A 1 141 ? -13.678 -34.268 27.209  1    50.37  ? 137 THR A CA  1 
ATOM   1131 C  C   . THR A 1 141 ? -14.926 -35.008 26.704  1    50.98  ? 137 THR A C   1 
ATOM   1132 O  O   . THR A 1 141 ? -15.079 -36.177 26.995  1    54.56  ? 137 THR A O   1 
ATOM   1133 C  CB  . THR A 1 141 ? -13.679 -34.105 28.735  1    51.23  ? 137 THR A CB  1 
ATOM   1134 O  OG1 . THR A 1 141 ? -14.717 -33.19  29.083  1    53.15  ? 137 THR A OG1 1 
ATOM   1135 C  CG2 . THR A 1 141 ? -12.403 -33.487 29.258  1    50.48  ? 137 THR A CG2 1 
ATOM   1136 N  N   . GLU A 1 142 ? -15.836 -34.357 25.986  1    47.9   ? 138 GLU A N   1 
ATOM   1137 C  CA  . GLU A 1 142 ? -17.048 -35.038 25.555  1    53.69  ? 138 GLU A CA  1 
ATOM   1138 C  C   . GLU A 1 142 ? -16.898 -35.638 24.156  1    54.36  ? 138 GLU A C   1 
ATOM   1139 O  O   . GLU A 1 142 ? -17.829 -36.272 23.67   1    61.63  ? 138 GLU A O   1 
ATOM   1140 C  CB  . GLU A 1 142 ? -18.281 -34.131 25.614  1    56.38  ? 138 GLU A CB  1 
ATOM   1141 C  CG  . GLU A 1 142 ? -18.671 -33.754 27.04   1    61.69  ? 138 GLU A CG  1 
ATOM   1142 C  CD  . GLU A 1 142 ? -19.229 -34.94  27.793  1    73.25  ? 138 GLU A CD  1 
ATOM   1143 O  OE1 . GLU A 1 142 ? -20.411 -35.282 27.594  1    81.49  ? 138 GLU A OE1 1 
ATOM   1144 O  OE2 . GLU A 1 142 ? -18.468 -35.549 28.567  1    84.09  ? 138 GLU A OE2 1 
ATOM   1145 N  N   . GLY A 1 143 ? -15.748 -35.438 23.509  1    49.23  ? 139 GLY A N   1 
ATOM   1146 C  CA  . GLY A 1 143 ? -15.485 -36.101 22.245  1    46.22  ? 139 GLY A CA  1 
ATOM   1147 C  C   . GLY A 1 143 ? -15.695 -35.154 21.066  1    46.09  ? 139 GLY A C   1 
ATOM   1148 O  O   . GLY A 1 143 ? -15.643 -35.585 19.903  1    42.01  ? 139 GLY A O   1 
ATOM   1149 N  N   . ALA A 1 144 ? -15.902 -33.864 21.386  1    40.25  ? 140 ALA A N   1 
ATOM   1150 C  CA  . ALA A 1 144 ? -16.053 -32.869 20.335  1    36.7   ? 140 ALA A CA  1 
ATOM   1151 C  C   . ALA A 1 144 ? -14.675 -32.401 19.868  1    37.64  ? 140 ALA A C   1 
ATOM   1152 O  O   . ALA A 1 144 ? -13.75  -32.325 20.676  1    37.89  ? 140 ALA A O   1 
ATOM   1153 C  CB  . ALA A 1 144 ? -16.838 -31.711 20.903  1    34.49  ? 140 ALA A CB  1 
ATOM   1154 N  N   . ILE A 1 145 ? -14.562 -32.03  18.586  1    37.59  ? 141 ILE A N   1 
ATOM   1155 C  CA  . ILE A 1 145 ? -13.411 -31.306 18.059  1    37.54  ? 141 ILE A CA  1 
ATOM   1156 C  C   . ILE A 1 145 ? -13.934 -30.085 17.305  1    38.69  ? 141 ILE A C   1 
ATOM   1157 O  O   . ILE A 1 145 ? -14.966 -30.157 16.613  1    36.63  ? 141 ILE A O   1 
ATOM   1158 C  CB  . ILE A 1 145 ? -12.549 -32.204 17.153  1    40.42  ? 141 ILE A CB  1 
ATOM   1159 C  CG1 . ILE A 1 145 ? -11.239 -31.52  16.726  1    39.04  ? 141 ILE A CG1 1 
ATOM   1160 C  CG2 . ILE A 1 145 ? -13.354 -32.65  15.917  1    42.01  ? 141 ILE A CG2 1 
ATOM   1161 C  CD1 . ILE A 1 145 ? -10.179 -32.466 16.19   1    32.23  ? 141 ILE A CD1 1 
ATOM   1162 N  N   . LYS A 1 146 ? -13.22  -28.951 17.441  1    36.53  ? 142 LYS A N   1 
ATOM   1163 C  CA  . LYS A 1 146 ? -13.693 -27.699 16.863  1    34.64  ? 142 LYS A CA  1 
ATOM   1164 C  C   . LYS A 1 146 ? -12.58  -26.94  16.149  1    35.37  ? 142 LYS A C   1 
ATOM   1165 O  O   . LYS A 1 146 ? -11.487 -26.816 16.704  1    36.04  ? 142 LYS A O   1 
ATOM   1166 C  CB  . LYS A 1 146 ? -14.3   -26.817 17.948  1    33.96  ? 142 LYS A CB  1 
ATOM   1167 C  CG  . LYS A 1 146 ? -15.319 -27.548 18.817  1    34.35  ? 142 LYS A CG  1 
ATOM   1168 C  CD  . LYS A 1 146 ? -16.202 -26.613 19.628  1    34.22  ? 142 LYS A CD  1 
ATOM   1169 C  CE  . LYS A 1 146 ? -16.994 -27.419 20.607  1    37.33  ? 142 LYS A CE  1 
ATOM   1170 N  NZ  . LYS A 1 146 ? -18.154 -26.678 21.077  1    37.66  ? 142 LYS A NZ  1 
ATOM   1171 N  N   . LEU A 1 147 ? -12.899 -26.393 14.954  1    32.7   ? 143 LEU A N   1 
ATOM   1172 C  CA  . LEU A 1 147 ? -12.017 -25.446 14.289  1    33.64  ? 143 LEU A CA  1 
ATOM   1173 C  C   . LEU A 1 147 ? -11.83  -24.242 15.207  1    35.02  ? 143 LEU A C   1 
ATOM   1174 O  O   . LEU A 1 147 ? -12.81  -23.703 15.72   1    35.64  ? 143 LEU A O   1 
ATOM   1175 C  CB  . LEU A 1 147 ? -12.454 -24.974 12.898  1    30.92  ? 143 LEU A CB  1 
ATOM   1176 C  CG  . LEU A 1 147 ? -13.168 -25.977 11.997  1    32.79  ? 143 LEU A CG  1 
ATOM   1177 C  CD1 . LEU A 1 147 ? -13.189 -25.39  10.618  1    36.41  ? 143 LEU A CD1 1 
ATOM   1178 C  CD2 . LEU A 1 147 ? -12.569 -27.334 12.019  1    31.36  ? 143 LEU A CD2 1 
ATOM   1179 N  N   . ALA A 1 148 ? -10.563 -23.819 15.375  1    34.55  ? 144 ALA A N   1 
ATOM   1180 C  CA  . ALA A 1 148 ? -10.247 -22.632 16.163  1    37.57  ? 144 ALA A CA  1 
ATOM   1181 C  C   . ALA A 1 148 ? -9.185  -21.838 15.421  1    35.57  ? 144 ALA A C   1 
ATOM   1182 O  O   . ALA A 1 148 ? -8.827  -22.215 14.289  1    35.31  ? 144 ALA A O   1 
ATOM   1183 C  CB  . ALA A 1 148 ? -9.817  -22.99  17.57   1    35.55  ? 144 ALA A CB  1 
ATOM   1184 N  N   . ASP A 1 149 ? -8.749  -20.745 16.057  1    33.11  ? 145 ASP A N   1 
ATOM   1185 C  CA  . ASP A 1 149 ? -7.773  -19.818 15.514  1    38.87  ? 145 ASP A CA  1 
ATOM   1186 C  C   . ASP A 1 149 ? -8.151  -19.314 14.119  1    35.43  ? 145 ASP A C   1 
ATOM   1187 O  O   . ASP A 1 149 ? -7.471  -19.656 13.161  1    38.14  ? 145 ASP A O   1 
ATOM   1188 C  CB  . ASP A 1 149 ? -6.323  -20.278 15.603  1    38.19  ? 145 ASP A CB  1 
ATOM   1189 C  CG  . ASP A 1 149 ? -5.315  -19.12  15.516  1    52.21  ? 145 ASP A CG  1 
ATOM   1190 O  OD1 . ASP A 1 149 ? -5.737  -17.966 15.169  1    54.37  ? 145 ASP A OD1 1 
ATOM   1191 O  OD2 . ASP A 1 149 ? -4.112  -19.334 15.845  1    53.73  ? 145 ASP A OD2 1 
ATOM   1192 N  N   . PHE A 1 150 ? -9.122  -18.396 14.071  1    34.62  ? 146 PHE A N   1 
ATOM   1193 C  CA  . PHE A 1 150 ? -9.611  -17.781 12.849  1    38.38  ? 146 PHE A CA  1 
ATOM   1194 C  C   . PHE A 1 150 ? -8.825  -16.505 12.547  1    43.66  ? 146 PHE A C   1 
ATOM   1195 O  O   . PHE A 1 150 ? -9.321  -15.633 11.828  1    43.45  ? 146 PHE A O   1 
ATOM   1196 C  CB  . PHE A 1 150 ? -11.116 -17.5   12.953  1    38.14  ? 146 PHE A CB  1 
ATOM   1197 C  CG  . PHE A 1 150 ? -11.969 -18.732 12.69   1    35.58  ? 146 PHE A CG  1 
ATOM   1198 C  CD1 . PHE A 1 150 ? -12.02  -19.763 13.625  1    32.83  ? 146 PHE A CD1 1 
ATOM   1199 C  CD2 . PHE A 1 150 ? -12.665 -18.869 11.483  1    32.46  ? 146 PHE A CD2 1 
ATOM   1200 C  CE1 . PHE A 1 150 ? -12.768 -20.902 13.373  1    31.67  ? 146 PHE A CE1 1 
ATOM   1201 C  CE2 . PHE A 1 150 ? -13.401 -20.01  11.228  1    30.61  ? 146 PHE A CE2 1 
ATOM   1202 C  CZ  . PHE A 1 150 ? -13.464 -21.013 12.179  1    32.2   ? 146 PHE A CZ  1 
ATOM   1203 N  N   . GLY A 1 151 ? -7.586  -16.425 13.067  1    41.03  ? 147 GLY A N   1 
ATOM   1204 C  CA  . GLY A 1 151 ? -6.751  -15.249 12.902  1    40.9   ? 147 GLY A CA  1 
ATOM   1205 C  C   . GLY A 1 151 ? -6.364  -15.019 11.444  1    43.31  ? 147 GLY A C   1 
ATOM   1206 O  O   . GLY A 1 151 ? -6.134  -13.882 11.091  1    47.73  ? 147 GLY A O   1 
ATOM   1207 N  N   . LEU A 1 152 ? -6.373  -16.074 10.612  1    41.92  ? 148 LEU A N   1 
ATOM   1208 C  CA  . LEU A 1 152 ? -6.071  -15.955 9.188   1    45.23  ? 148 LEU A CA  1 
ATOM   1209 C  C   . LEU A 1 152 ? -7.284  -16.142 8.277   1    42.16  ? 148 LEU A C   1 
ATOM   1210 O  O   . LEU A 1 152 ? -7.13   -16.191 7.063   1    40.88  ? 148 LEU A O   1 
ATOM   1211 C  CB  . LEU A 1 152 ? -4.982  -16.96  8.825   1    49.51  ? 148 LEU A CB  1 
ATOM   1212 C  CG  . LEU A 1 152 ? -3.589  -16.545 9.304   1    59.8   ? 148 LEU A CG  1 
ATOM   1213 C  CD1 . LEU A 1 152 ? -2.672  -17.744 9.292   1    68.01  ? 148 LEU A CD1 1 
ATOM   1214 C  CD2 . LEU A 1 152 ? -3.012  -15.413 8.483   1    56     ? 148 LEU A CD2 1 
ATOM   1215 N  N   . ALA A 1 153 ? -8.479  -16.242 8.859   1    38.56  ? 149 ALA A N   1 
ATOM   1216 C  CA  . ALA A 1 153 ? -9.674  -16.488 8.078   1    39.21  ? 149 ALA A CA  1 
ATOM   1217 C  C   . ALA A 1 153 ? -10.004 -15.264 7.218   1    38.59  ? 149 ALA A C   1 
ATOM   1218 O  O   . ALA A 1 153 ? -9.437  -14.172 7.431   1    38.38  ? 149 ALA A O   1 
ATOM   1219 C  CB  . ALA A 1 153 ? -10.807 -16.877 9.012   1    37.25  ? 149 ALA A CB  1 
ATOM   1220 N  N   . ARG A 1 154 ? -10.86  -15.45  6.25    1    34.44  ? 150 ARG A N   1 
ATOM   1221 C  CA  . ARG A 1 154 ? -11.235 -14.355 5.333   1    41.91  ? 150 ARG A CA  1 
ATOM   1222 C  C   . ARG A 1 154 ? -12.618 -14.599 4.728   1    41.13  ? 150 ARG A C   1 
ATOM   1223 O  O   . ARG A 1 154 ? -12.916 -15.75  4.381   1    42.6   ? 150 ARG A O   1 
ATOM   1224 C  CB  . ARG A 1 154 ? -10.245 -14.321 4.172   1    40.73  ? 150 ARG A CB  1 
ATOM   1225 C  CG  . ARG A 1 154 ? -9.932  -12.938 3.63    1    44.13  ? 150 ARG A CG  1 
ATOM   1226 C  CD  . ARG A 1 154 ? -9.562  -13.098 2.18    1    46.39  ? 150 ARG A CD  1 
ATOM   1227 N  NE  . ARG A 1 154 ? -9.968  -11.925 1.406   1    43.41  ? 150 ARG A NE  1 
ATOM   1228 C  CZ  . ARG A 1 154 ? -9.486  -10.712 1.584   1    45.26  ? 150 ARG A CZ  1 
ATOM   1229 N  NH1 . ARG A 1 154 ? -10.3   -9.746  1.945   1    39.98  ? 150 ARG A NH1 1 
ATOM   1230 N  NH2 . ARG A 1 154 ? -8.205  -10.465 1.393   1    44.55  ? 150 ARG A NH2 1 
ATOM   1231 N  N   . ALA A 1 155 ? -13.414 -13.575 4.591   1    37.16  ? 151 ALA A N   1 
ATOM   1232 C  CA  . ALA A 1 155 ? -14.704 -13.679 3.918   1    35.77  ? 151 ALA A CA  1 
ATOM   1233 C  C   . ALA A 1 155 ? -14.469 -13.576 2.418   1    37.56  ? 151 ALA A C   1 
ATOM   1234 O  O   . ALA A 1 155 ? -13.842 -12.631 1.953   1    41.12  ? 151 ALA A O   1 
ATOM   1235 C  CB  . ALA A 1 155 ? -15.646 -12.59  4.378   1    33.34  ? 151 ALA A CB  1 
ATOM   1236 N  N   . PHE A 1 156 ? -14.951 -14.564 1.672   1    36.73  ? 152 PHE A N   1 
ATOM   1237 C  CA  . PHE A 1 156 ? -14.692 -14.589 0.242   1    35.8   ? 152 PHE A CA  1 
ATOM   1238 C  C   . PHE A 1 156 ? -15.964 -14.229 -0.504  1    36.07  ? 152 PHE A C   1 
ATOM   1239 O  O   . PHE A 1 156 ? -17.072 -14.301 0.05    1    33.19  ? 152 PHE A O   1 
ATOM   1240 C  CB  . PHE A 1 156 ? -14.11  -15.935 -0.222  1    35.92  ? 152 PHE A CB  1 
ATOM   1241 C  CG  . PHE A 1 156 ? -14.933 -17.211 -0.068  1    34.39  ? 152 PHE A CG  1 
ATOM   1242 C  CD1 . PHE A 1 156 ? -14.888 -17.952 1.11    1    32.75  ? 152 PHE A CD1 1 
ATOM   1243 C  CD2 . PHE A 1 156 ? -15.732 -17.679 -1.108  1    32.49  ? 152 PHE A CD2 1 
ATOM   1244 C  CE1 . PHE A 1 156 ? -15.621 -19.14  1.241   1    30.78  ? 152 PHE A CE1 1 
ATOM   1245 C  CE2 . PHE A 1 156 ? -16.426 -18.878 -0.99   1    32.21  ? 152 PHE A CE2 1 
ATOM   1246 C  CZ  . PHE A 1 156 ? -16.362 -19.625 0.185   1    29.27  ? 152 PHE A CZ  1 
ATOM   1247 N  N   . GLY A 1 157 ? -15.75  -13.797 -1.758  1    36.97  ? 153 GLY A N   1 
ATOM   1248 C  CA  . GLY A 1 157 ? -16.822 -13.587 -2.708  1    34.6   ? 153 GLY A CA  1 
ATOM   1249 C  C   . GLY A 1 157 ? -16.806 -14.712 -3.742  1    35.17  ? 153 GLY A C   1 
ATOM   1250 O  O   . GLY A 1 157 ? -15.815 -15.436 -3.833  1    33.94  ? 153 GLY A O   1 
ATOM   1251 N  N   . VAL A 1 158 ? -17.865 -14.772 -4.566  1    34.3   ? 154 VAL A N   1 
ATOM   1252 C  CA  . VAL A 1 158 ? -18.036 -15.846 -5.536  1    36.74  ? 154 VAL A CA  1 
ATOM   1253 C  C   . VAL A 1 158 ? -18.164 -15.192 -6.911  1    36.63  ? 154 VAL A C   1 
ATOM   1254 O  O   . VAL A 1 158 ? -19.076 -14.384 -7.108  1    38.95  ? 154 VAL A O   1 
ATOM   1255 C  CB  . VAL A 1 158 ? -19.308 -16.689 -5.213  1    37.82  ? 154 VAL A CB  1 
ATOM   1256 C  CG1 . VAL A 1 158 ? -19.606 -17.706 -6.31   1    36.08  ? 154 VAL A CG1 1 
ATOM   1257 C  CG2 . VAL A 1 158 ? -19.235 -17.357 -3.859  1    32.04  ? 154 VAL A CG2 1 
ATOM   1258 N  N   . PRO A 1 159 ? -17.268 -15.453 -7.893  1    35.79  ? 155 PRO A N   1 
ATOM   1259 C  CA  . PRO A 1 159 ? -16.046 -16.223 -7.699  1    35.44  ? 155 PRO A CA  1 
ATOM   1260 C  C   . PRO A 1 159 ? -15.04  -15.477 -6.826  1    38.34  ? 155 PRO A C   1 
ATOM   1261 O  O   . PRO A 1 159 ? -15.184 -14.261 -6.606  1    37.14  ? 155 PRO A O   1 
ATOM   1262 C  CB  . PRO A 1 159 ? -15.486 -16.436 -9.145  1    32.58  ? 155 PRO A CB  1 
ATOM   1263 C  CG  . PRO A 1 159 ? -16.06  -15.366 -9.972  1    34.04  ? 155 PRO A CG  1 
ATOM   1264 C  CD  . PRO A 1 159 ? -17.395 -14.984 -9.285  1    37.54  ? 155 PRO A CD  1 
ATOM   1265 N  N   . VAL A 1 160 ? -13.997 -16.22  -6.389  1    37.52  ? 156 VAL A N   1 
ATOM   1266 C  CA  . VAL A 1 160 ? -12.956 -15.647 -5.543  1    37.05  ? 156 VAL A CA  1 
ATOM   1267 C  C   . VAL A 1 160 ? -12.099 -14.652 -6.337  1    39.84  ? 156 VAL A C   1 
ATOM   1268 O  O   . VAL A 1 160 ? -11.939 -14.714 -7.55   1    40.22  ? 156 VAL A O   1 
ATOM   1269 C  CB  . VAL A 1 160 ? -12.086 -16.721 -4.874  1    35.14  ? 156 VAL A CB  1 
ATOM   1270 C  CG1 . VAL A 1 160 ? -12.918 -17.627 -3.978  1    30.18  ? 156 VAL A CG1 1 
ATOM   1271 C  CG2 . VAL A 1 160 ? -11.308 -17.505 -5.93   1    31.05  ? 156 VAL A CG2 1 
ATOM   1272 N  N   . ARG A 1 161 ? -11.556 -13.725 -5.571  1    43.73  ? 157 ARG A N   1 
ATOM   1273 C  CA  . ARG A 1 161 ? -10.607 -12.764 -6.138  1    47.4   ? 157 ARG A CA  1 
ATOM   1274 C  C   . ARG A 1 161 ? -9.248  -13.236 -5.635  1    44.37  ? 157 ARG A C   1 
ATOM   1275 O  O   . ARG A 1 161 ? -9.198  -14.233 -4.897  1    39.9   ? 157 ARG A O   1 
ATOM   1276 C  CB  . ARG A 1 161 ? -10.933 -11.408 -5.518  1    46.27  ? 157 ARG A CB  1 
ATOM   1277 C  CG  . ARG A 1 161 ? -11.394 -10.264 -6.403  1    59.66  ? 157 ARG A CG  1 
ATOM   1278 C  CD  . ARG A 1 161 ? -11.597 -9.024  -5.546  1    64.54  ? 157 ARG A CD  1 
ATOM   1279 N  NE  . ARG A 1 161 ? -10.725 -8.997  -4.366  1    70.75  ? 157 ARG A NE  1 
ATOM   1280 C  CZ  . ARG A 1 161 ? -11.091 -8.562  -3.168  1    74.11  ? 157 ARG A CZ  1 
ATOM   1281 N  NH1 . ARG A 1 161 ? -10.221 -8.543  -2.175  1    70     ? 157 ARG A NH1 1 
ATOM   1282 N  NH2 . ARG A 1 161 ? -12.327 -8.148  -2.967  1    64.17  ? 157 ARG A NH2 1 
ATOM   1283 N  N   . THR A 1 162 ? -8.189  -12.557 -6.034  1    43.53  ? 158 THR A N   1 
ATOM   1284 C  CA  . THR A 1 162 ? -6.869  -12.89  -5.518  1    39.05  ? 158 THR A CA  1 
ATOM   1285 C  C   . THR A 1 162 ? -6.824  -12.461 -4.057  1    36.32  ? 158 THR A C   1 
ATOM   1286 O  O   . THR A 1 162 ? -7.14   -11.314 -3.763  1    38.56  ? 158 THR A O   1 
ATOM   1287 C  CB  . THR A 1 162 ? -5.764  -12.187 -6.328  1    42.47  ? 158 THR A CB  1 
ATOM   1288 O  OG1 . THR A 1 162 ? -5.799  -12.767 -7.635  1    47.27  ? 158 THR A OG1 1 
ATOM   1289 C  CG2 . THR A 1 162 ? -4.362  -12.374 -5.74   1    38.62  ? 158 THR A CG2 1 
ATOM   1290 N  N   . TYR A 1 163 ? -6.397  -13.36  -3.171  1    34.87  ? 159 TYR A N   1 
ATOM   1291 C  CA  . TYR A 1 163 ? -6.225  -13.021 -1.761  1    38.77  ? 159 TYR A CA  1 
ATOM   1292 C  C   . TYR A 1 163 ? -4.753  -13.181 -1.35   1    40.16  ? 159 TYR A C   1 
ATOM   1293 O  O   . TYR A 1 163 ? -3.897  -13.46  -2.174  1    38.03  ? 159 TYR A O   1 
ATOM   1294 C  CB  . TYR A 1 163 ? -7.153  -13.878 -0.895  1    36.97  ? 159 TYR A CB  1 
ATOM   1295 C  CG  . TYR A 1 163 ? -8.623  -13.859 -1.308  1    38.34  ? 159 TYR A CG  1 
ATOM   1296 C  CD1 . TYR A 1 163 ? -9.302  -12.678 -1.575  1    38.18  ? 159 TYR A CD1 1 
ATOM   1297 C  CD2 . TYR A 1 163 ? -9.338  -15.046 -1.364  1    37.58  ? 159 TYR A CD2 1 
ATOM   1298 C  CE1 . TYR A 1 163 ? -10.632 -12.694 -1.938  1    43.27  ? 159 TYR A CE1 1 
ATOM   1299 C  CE2 . TYR A 1 163 ? -10.662 -15.082 -1.745  1    38.48  ? 159 TYR A CE2 1 
ATOM   1300 C  CZ  . TYR A 1 163 ? -11.307 -13.903 -2.05   1    46.15  ? 159 TYR A CZ  1 
ATOM   1301 O  OH  . TYR A 1 163 ? -12.632 -13.966 -2.409  1    49.66  ? 159 TYR A OH  1 
HETATM 1302 N  N   . TPO A 1 164 ? -4.471  -13.032 -0.053  1    40.52  ? 160 TPO A N   1 
HETATM 1303 C  CA  . TPO A 1 164 ? -3.12   -13.121 0.47    1    42.89  ? 160 TPO A CA  1 
HETATM 1304 C  CB  . TPO A 1 164 ? -3.131  -12.92  1.997   1    43.97  ? 160 TPO A CB  1 
HETATM 1305 C  CG2 . TPO A 1 164 ? -1.738  -12.726 2.577   1    39.56  ? 160 TPO A CG2 1 
HETATM 1306 O  OG1 . TPO A 1 164 ? -3.886  -11.689 2.231   1    42.26  ? 160 TPO A OG1 1 
HETATM 1307 P  P   . TPO A 1 164 ? -5.297  -11.653 2.999   1    41.68  ? 160 TPO A P   1 
HETATM 1308 O  O1P . TPO A 1 164 ? -6.259  -12.527 2.218   1    38.08  ? 160 TPO A O1P 1 
HETATM 1309 O  O2P . TPO A 1 164 ? -5.608  -10.173 2.987   1    37.36  ? 160 TPO A O2P 1 
HETATM 1310 O  O3P . TPO A 1 164 ? -5.1    -12.247 4.422   1    39.33  ? 160 TPO A O3P 1 
HETATM 1311 C  C   . TPO A 1 164 ? -2.473  -14.458 0.105   1    43.95  ? 160 TPO A C   1 
HETATM 1312 O  O   . TPO A 1 164 ? -3.065  -15.535 0.272   1    42.31  ? 160 TPO A O   1 
ATOM   1313 N  N   . HIS A 1 165 ? -1.22   -14.361 -0.355  1    44.62  ? 161 HIS A N   1 
ATOM   1314 C  CA  . HIS A 1 165 ? -0.459  -15.545 -0.724  1    48.29  ? 161 HIS A CA  1 
ATOM   1315 C  C   . HIS A 1 165 ? 0.148   -16.23  0.512   1    48.24  ? 161 HIS A C   1 
ATOM   1316 O  O   . HIS A 1 165 ? 0.146   -17.452 0.596   1    44.17  ? 161 HIS A O   1 
ATOM   1317 C  CB  . HIS A 1 165 ? 0.504   -15.179 -1.855  1    48.09  ? 161 HIS A CB  1 
ATOM   1318 C  CG  . HIS A 1 165 ? 1.513   -16.222 -2.146  1    56.78  ? 161 HIS A CG  1 
ATOM   1319 N  ND1 . HIS A 1 165 ? 1.229   -17.441 -2.733  1    56.7   ? 161 HIS A ND1 1 
ATOM   1320 C  CD2 . HIS A 1 165 ? 2.829   -16.205 -1.907  1    59.59  ? 161 HIS A CD2 1 
ATOM   1321 C  CE1 . HIS A 1 165 ? 2.35    -18.129 -2.844  1    56.05  ? 161 HIS A CE1 1 
ATOM   1322 N  NE2 . HIS A 1 165 ? 3.336   -17.391 -2.362  1    64.45  ? 161 HIS A NE2 1 
ATOM   1323 N  N   . GLU A 1 166 ? 0.629   -15.443 1.48    1    57.84  ? 162 GLU A N   1 
ATOM   1324 C  CA  . GLU A 1 166 ? 1.287   -15.951 2.685   1    61.09  ? 162 GLU A CA  1 
ATOM   1325 C  C   . GLU A 1 166 ? 0.218   -16.504 3.622   1    53.1   ? 162 GLU A C   1 
ATOM   1326 O  O   . GLU A 1 166 ? -0.079  -15.881 4.64    1    53.03  ? 162 GLU A O   1 
ATOM   1327 C  CB  . GLU A 1 166 ? 2.119   -14.901 3.442   1    66.32  ? 162 GLU A CB  1 
ATOM   1328 C  CG  . GLU A 1 166 ? 3.163   -14.169 2.581   1    81.06  ? 162 GLU A CG  1 
ATOM   1329 C  CD  . GLU A 1 166 ? 2.76    -13.341 1.343   1    89.11  ? 162 GLU A CD  1 
ATOM   1330 O  OE1 . GLU A 1 166 ? 1.575   -12.879 1.241   1    86.35  ? 162 GLU A OE1 1 
ATOM   1331 O  OE2 . GLU A 1 166 ? 3.636   -13.177 0.438   1    78.06  ? 162 GLU A OE2 1 
ATOM   1332 N  N   . VAL A 1 167 ? -0.319  -17.684 3.274   1    46.57  ? 163 VAL A N   1 
ATOM   1333 C  CA  . VAL A 1 167 ? -1.449  -18.265 3.998   1    44.64  ? 163 VAL A CA  1 
ATOM   1334 C  C   . VAL A 1 167 ? -1.174  -19.758 4.151   1    40.64  ? 163 VAL A C   1 
ATOM   1335 O  O   . VAL A 1 167 ? -0.58   -20.372 3.262   1    43.96  ? 163 VAL A O   1 
ATOM   1336 C  CB  . VAL A 1 167 ? -2.822  -18.031 3.305   1    43.07  ? 163 VAL A CB  1 
ATOM   1337 C  CG1 . VAL A 1 167 ? -3.29   -16.58  3.402   1    41.47  ? 163 VAL A CG1 1 
ATOM   1338 C  CG2 . VAL A 1 167 ? -2.799  -18.484 1.85    1    38.99  ? 163 VAL A CG2 1 
ATOM   1339 N  N   . VAL A 1 168 ? -1.606  -20.3   5.286   1    34.67  ? 164 VAL A N   1 
ATOM   1340 C  CA  . VAL A 1 168 ? -1.516  -21.701 5.654   1    35.37  ? 164 VAL A CA  1 
ATOM   1341 C  C   . VAL A 1 168 ? -0.108  -22.038 6.145   1    40.36  ? 164 VAL A C   1 
ATOM   1342 O  O   . VAL A 1 168 ? 0.892   -21.684 5.514   1    41.3   ? 164 VAL A O   1 
ATOM   1343 C  CB  . VAL A 1 168 ? -2.019  -22.706 4.614   1    32.7   ? 164 VAL A CB  1 
ATOM   1344 C  CG1 . VAL A 1 168 ? -2.362  -24.025 5.313   1    31.78  ? 164 VAL A CG1 1 
ATOM   1345 C  CG2 . VAL A 1 168 ? -3.249  -22.195 3.867   1    29     ? 164 VAL A CG2 1 
ATOM   1346 N  N   . THR A 1 169 ? -0.033  -22.653 7.334   1    38.7   ? 165 THR A N   1 
ATOM   1347 C  CA  . THR A 1 169 ? 1.218   -23.205 7.815   1    40.79  ? 165 THR A CA  1 
ATOM   1348 C  C   . THR A 1 169 ? 1.726   -24.21  6.758   1    41.71  ? 165 THR A C   1 
ATOM   1349 O  O   . THR A 1 169 ? 0.961   -25.033 6.25    1    38.12  ? 165 THR A O   1 
ATOM   1350 C  CB  . THR A 1 169 ? 0.976   -23.832 9.199   1    39.92  ? 165 THR A CB  1 
ATOM   1351 O  OG1 . THR A 1 169 ? 0.561   -22.758 10.037  1    36.89  ? 165 THR A OG1 1 
ATOM   1352 C  CG2 . THR A 1 169 ? 2.215   -24.514 9.764   1    35.9   ? 165 THR A CG2 1 
ATOM   1353 N  N   . LEU A 1 170 ? 3.037   -24.159 6.492   1    40.17  ? 166 LEU A N   1 
ATOM   1354 C  CA  . LEU A 1 170 ? 3.72    -24.738 5.354   1    38.63  ? 166 LEU A CA  1 
ATOM   1355 C  C   . LEU A 1 170 ? 3.37    -26.202 5.193   1    40.06  ? 166 LEU A C   1 
ATOM   1356 O  O   . LEU A 1 170 ? 3.119   -26.624 4.065   1    38.73  ? 166 LEU A O   1 
ATOM   1357 C  CB  . LEU A 1 170 ? 5.236   -24.666 5.543   1    40.21  ? 166 LEU A CB  1 
ATOM   1358 C  CG  . LEU A 1 170 ? 6.081   -25.231 4.395   1    38.89  ? 166 LEU A CG  1 
ATOM   1359 C  CD1 . LEU A 1 170 ? 5.679   -24.535 3.085   1    37.48  ? 166 LEU A CD1 1 
ATOM   1360 C  CD2 . LEU A 1 170 ? 7.564   -25.045 4.664   1    37.47  ? 166 LEU A CD2 1 
ATOM   1361 N  N   . TRP A 1 171 ? 3.476   -26.966 6.296   1    37.19  ? 167 TRP A N   1 
ATOM   1362 C  CA  . TRP A 1 171 ? 3.253   -28.4   6.188   1    37.1   ? 167 TRP A CA  1 
ATOM   1363 C  C   . TRP A 1 171 ? 1.843   -28.709 5.68    1    38.79  ? 167 TRP A C   1 
ATOM   1364 O  O   . TRP A 1 171 ? 1.616   -29.836 5.225   1    44.24  ? 167 TRP A O   1 
ATOM   1365 C  CB  . TRP A 1 171 ? 3.508   -29.125 7.511   1    34.9   ? 167 TRP A CB  1 
ATOM   1366 C  CG  . TRP A 1 171 ? 4.931   -29.096 7.962   1    37.21  ? 167 TRP A CG  1 
ATOM   1367 C  CD1 . TRP A 1 171 ? 6.03    -28.637 7.281   1    37.53  ? 167 TRP A CD1 1 
ATOM   1368 C  CD2 . TRP A 1 171 ? 5.399   -29.572 9.231   1    37.97  ? 167 TRP A CD2 1 
ATOM   1369 N  NE1 . TRP A 1 171 ? 7.147   -28.77  8.063   1    39.52  ? 167 TRP A NE1 1 
ATOM   1370 C  CE2 . TRP A 1 171 ? 6.802   -29.357 9.253   1    40.24  ? 167 TRP A CE2 1 
ATOM   1371 C  CE3 . TRP A 1 171 ? 4.773   -30.145 10.346  1    39.79  ? 167 TRP A CE3 1 
ATOM   1372 C  CZ2 . TRP A 1 171 ? 7.595   -29.719 10.343  1    39.37  ? 167 TRP A CZ2 1 
ATOM   1373 C  CZ3 . TRP A 1 171 ? 5.558   -30.51  11.426  1    40.05  ? 167 TRP A CZ3 1 
ATOM   1374 C  CH2 . TRP A 1 171 ? 6.954   -30.313 11.413  1    38.29  ? 167 TRP A CH2 1 
ATOM   1375 N  N   . TYR A 1 172 ? 0.921   -27.723 5.738   1    34.5   ? 168 TYR A N   1 
ATOM   1376 C  CA  . TYR A 1 172 ? -0.5    -27.974 5.495   1    36.98  ? 168 TYR A CA  1 
ATOM   1377 C  C   . TYR A 1 172 ? -0.982  -27.213 4.26    1    36.86  ? 168 TYR A C   1 
ATOM   1378 O  O   . TYR A 1 172 ? -2.183  -27.19  3.978   1    32.42  ? 168 TYR A O   1 
ATOM   1379 C  CB  . TYR A 1 172 ? -1.364  -27.695 6.734   1    29.6   ? 168 TYR A CB  1 
ATOM   1380 C  CG  . TYR A 1 172 ? -0.872  -28.501 7.91    1    30.3   ? 168 TYR A CG  1 
ATOM   1381 C  CD1 . TYR A 1 172 ? -1.302  -29.804 8.099   1    31.25  ? 168 TYR A CD1 1 
ATOM   1382 C  CD2 . TYR A 1 172 ? 0.08    -27.984 8.791   1    32.67  ? 168 TYR A CD2 1 
ATOM   1383 C  CE1 . TYR A 1 172 ? -0.856  -30.567 9.175   1    31.64  ? 168 TYR A CE1 1 
ATOM   1384 C  CE2 . TYR A 1 172 ? 0.545   -28.73  9.861   1    31.83  ? 168 TYR A CE2 1 
ATOM   1385 C  CZ  . TYR A 1 172 ? 0.09    -30.03  10.037  1    33.15  ? 168 TYR A CZ  1 
ATOM   1386 O  OH  . TYR A 1 172 ? 0.585   -30.767 11.073  1    35.09  ? 168 TYR A OH  1 
ATOM   1387 N  N   . ARG A 1 173 ? -0.015  -26.607 3.548   1    37.91  ? 169 ARG A N   1 
ATOM   1388 C  CA  . ARG A 1 173 ? -0.317  -25.68  2.463   1    37.68  ? 169 ARG A CA  1 
ATOM   1389 C  C   . ARG A 1 173 ? -0.52   -26.461 1.166   1    36.43  ? 169 ARG A C   1 
ATOM   1390 O  O   . ARG A 1 173 ? 0.3     -27.31  0.821   1    36.54  ? 169 ARG A O   1 
ATOM   1391 C  CB  . ARG A 1 173 ? 0.814   -24.657 2.306   1    33.15  ? 169 ARG A CB  1 
ATOM   1392 C  CG  . ARG A 1 173 ? 0.51    -23.578 1.266   1    36.81  ? 169 ARG A CG  1 
ATOM   1393 C  CD  . ARG A 1 173 ? 1.616   -22.528 1.167   1    34.79  ? 169 ARG A CD  1 
ATOM   1394 N  NE  . ARG A 1 173 ? 1.929   -22.061 2.529   1    34.88  ? 169 ARG A NE  1 
ATOM   1395 C  CZ  . ARG A 1 173 ? 3.067   -21.519 2.925   1    35.25  ? 169 ARG A CZ  1 
ATOM   1396 N  NH1 . ARG A 1 173 ? 4.074   -21.368 2.104   1    35.52  ? 169 ARG A NH1 1 
ATOM   1397 N  NH2 . ARG A 1 173 ? 3.202   -21.144 4.162   1    36.6   ? 169 ARG A NH2 1 
ATOM   1398 N  N   . ALA A 1 174 ? -1.59   -26.096 0.452   1    33.39  ? 170 ALA A N   1 
ATOM   1399 C  CA  . ALA A 1 174 ? -2.009  -26.727 -0.793  1    33.8   ? 170 ALA A CA  1 
ATOM   1400 C  C   . ALA A 1 174 ? -1.065  -26.399 -1.948  1    35.15  ? 170 ALA A C   1 
ATOM   1401 O  O   . ALA A 1 174 ? -0.543  -25.286 -2.04   1    40.87  ? 170 ALA A O   1 
ATOM   1402 C  CB  . ALA A 1 174 ? -3.403  -26.253 -1.131  1    28.57  ? 170 ALA A CB  1 
ATOM   1403 N  N   . PRO A 1 175 ? -0.888  -27.319 -2.905  1    32.79  ? 171 PRO A N   1 
ATOM   1404 C  CA  . PRO A 1 175 ? 0.021   -27.105 -4.024  1    35.03  ? 171 PRO A CA  1 
ATOM   1405 C  C   . PRO A 1 175 ? -0.263  -25.838 -4.825  1    35.74  ? 171 PRO A C   1 
ATOM   1406 O  O   . PRO A 1 175 ? 0.701   -25.216 -5.304  1    38.94  ? 171 PRO A O   1 
ATOM   1407 C  CB  . PRO A 1 175 ? -0.066  -28.387 -4.87   1    35.82  ? 171 PRO A CB  1 
ATOM   1408 C  CG  . PRO A 1 175 ? -1.363  -29.015 -4.44   1    35.43  ? 171 PRO A CG  1 
ATOM   1409 C  CD  . PRO A 1 175 ? -1.52   -28.628 -2.958  1    34.84  ? 171 PRO A CD  1 
ATOM   1410 N  N   . GLU A 1 176 ? -1.544  -25.452 -4.938  1    31.2   ? 172 GLU A N   1 
ATOM   1411 C  CA  . GLU A 1 176 ? -1.904  -24.315 -5.768  1    34.58  ? 172 GLU A CA  1 
ATOM   1412 C  C   . GLU A 1 176 ? -1.39   -23.028 -5.124  1    36.84  ? 172 GLU A C   1 
ATOM   1413 O  O   . GLU A 1 176 ? -1.109  -22.067 -5.856  1    37.88  ? 172 GLU A O   1 
ATOM   1414 C  CB  . GLU A 1 176 ? -3.407  -24.221 -6.093  1    35.88  ? 172 GLU A CB  1 
ATOM   1415 C  CG  . GLU A 1 176 ? -4.365  -24.169 -4.897  1    35.78  ? 172 GLU A CG  1 
ATOM   1416 C  CD  . GLU A 1 176 ? -4.879  -25.494 -4.342  1    34.07  ? 172 GLU A CD  1 
ATOM   1417 O  OE1 . GLU A 1 176 ? -6.054  -25.587 -3.895  1    31     ? 172 GLU A OE1 1 
ATOM   1418 O  OE2 . GLU A 1 176 ? -4.071  -26.445 -4.373  1    34.14  ? 172 GLU A OE2 1 
ATOM   1419 N  N   . ILE A 1 177 ? -1.257  -23.011 -3.773  1    33.55  ? 173 ILE A N   1 
ATOM   1420 C  CA  . ILE A 1 177 ? -0.657  -21.844 -3.131  1    36.24  ? 173 ILE A CA  1 
ATOM   1421 C  C   . ILE A 1 177 ? 0.863   -21.865 -3.366  1    39.21  ? 173 ILE A C   1 
ATOM   1422 O  O   . ILE A 1 177 ? 1.471   -20.844 -3.71   1    38.65  ? 173 ILE A O   1 
ATOM   1423 C  CB  . ILE A 1 177 ? -1.044  -21.746 -1.646  1    37.15  ? 173 ILE A CB  1 
ATOM   1424 C  CG1 . ILE A 1 177 ? -2.56   -21.726 -1.449  1    39.68  ? 173 ILE A CG1 1 
ATOM   1425 C  CG2 . ILE A 1 177 ? -0.409  -20.521 -0.998  1    34.81  ? 173 ILE A CG2 1 
ATOM   1426 C  CD1 . ILE A 1 177 ? -3.004  -21.836 -0.002  1    40.72  ? 173 ILE A CD1 1 
ATOM   1427 N  N   . LEU A 1 178 ? 1.457   -23.058 -3.23   1    35.13  ? 174 LEU A N   1 
ATOM   1428 C  CA  . LEU A 1 178 ? 2.879   -23.226 -3.431  1    37.66  ? 174 LEU A CA  1 
ATOM   1429 C  C   . LEU A 1 178 ? 3.28    -22.839 -4.852  1    40.24  ? 174 LEU A C   1 
ATOM   1430 O  O   . LEU A 1 178 ? 4.4     -22.319 -5.032  1    38.48  ? 174 LEU A O   1 
ATOM   1431 C  CB  . LEU A 1 178 ? 3.279   -24.645 -3.06   1    33.86  ? 174 LEU A CB  1 
ATOM   1432 C  CG  . LEU A 1 178 ? 3.265   -24.943 -1.564  1    32.06  ? 174 LEU A CG  1 
ATOM   1433 C  CD1 . LEU A 1 178 ? 3.185   -26.424 -1.341  1    32.12  ? 174 LEU A CD1 1 
ATOM   1434 C  CD2 . LEU A 1 178 ? 4.518   -24.368 -0.932  1    31.23  ? 174 LEU A CD2 1 
ATOM   1435 N  N   . LEU A 1 179 ? 2.367   -23.049 -5.829  1    36.27  ? 175 LEU A N   1 
ATOM   1436 C  CA  . LEU A 1 179 ? 2.707   -22.734 -7.218  1    39.27  ? 175 LEU A CA  1 
ATOM   1437 C  C   . LEU A 1 179 ? 2.297   -21.298 -7.583  1    43.49  ? 175 LEU A C   1 
ATOM   1438 O  O   . LEU A 1 179 ? 2.313   -20.92  -8.755  1    44.87  ? 175 LEU A O   1 
ATOM   1439 C  CB  . LEU A 1 179 ? 2.117   -23.767 -8.169  1    34.66  ? 175 LEU A CB  1 
ATOM   1440 C  CG  . LEU A 1 179 ? 2.765   -25.151 -8.139  1    36.43  ? 175 LEU A CG  1 
ATOM   1441 C  CD1 . LEU A 1 179 ? 1.973   -26.117 -8.984  1    35.72  ? 175 LEU A CD1 1 
ATOM   1442 C  CD2 . LEU A 1 179 ? 4.226   -25.147 -8.551  1    32.39  ? 175 LEU A CD2 1 
ATOM   1443 N  N   . GLY A 1 180 ? 1.871   -20.517 -6.576  1    41.04  ? 176 GLY A N   1 
ATOM   1444 C  CA  . GLY A 1 180 ? 1.666   -19.096 -6.756  1    40.42  ? 176 GLY A CA  1 
ATOM   1445 C  C   . GLY A 1 180 ? 0.469   -18.765 -7.645  1    41.72  ? 176 GLY A C   1 
ATOM   1446 O  O   . GLY A 1 180 ? 0.459   -17.714 -8.293  1    40.19  ? 176 GLY A O   1 
ATOM   1447 N  N   . CYS A 1 181 ? -0.52   -19.672 -7.681  1    40.55  ? 177 CYS A N   1 
ATOM   1448 C  CA  . CYS A 1 181 ? -1.726  -19.499 -8.482  1    41.45  ? 177 CYS A CA  1 
ATOM   1449 C  C   . CYS A 1 181 ? -2.396  -18.157 -8.153  1    39.77  ? 177 CYS A C   1 
ATOM   1450 O  O   . CYS A 1 181 ? -2.377  -17.68  -7.008  1    35.86  ? 177 CYS A O   1 
ATOM   1451 C  CB  . CYS A 1 181 ? -2.627  -20.733 -8.378  1    44.13  ? 177 CYS A CB  1 
ATOM   1452 S  SG  . CYS A 1 181 ? -1.952  -22.188 -9.273  1    58.73  ? 177 CYS A SG  1 
ATOM   1453 N  N   . LYS A 1 182 ? -2.947  -17.522 -9.195  1    37.33  ? 178 LYS A N   1 
ATOM   1454 C  CA  . LYS A 1 182 ? -3.632  -16.256 -9.016  1    38.78  ? 178 LYS A CA  1 
ATOM   1455 C  C   . LYS A 1 182 ? -4.797  -16.404 -8.028  1    37.73  ? 178 LYS A C   1 
ATOM   1456 O  O   . LYS A 1 182 ? -5.048  -15.528 -7.212  1    38.31  ? 178 LYS A O   1 
ATOM   1457 C  CB  . LYS A 1 182 ? -4.042  -15.797 -10.416 1    41.84  ? 178 LYS A CB  1 
ATOM   1458 C  CG  . LYS A 1 182 ? -4.795  -14.479 -10.43  1    51.04  ? 178 LYS A CG  1 
ATOM   1459 C  CD  . LYS A 1 182 ? -5.157  -14.032 -11.84  1    53.57  ? 178 LYS A CD  1 
ATOM   1460 C  CE  . LYS A 1 182 ? -5.596  -12.586 -11.782 1    61.68  ? 178 LYS A CE  1 
ATOM   1461 N  NZ  . LYS A 1 182 ? -6.413  -12.148 -12.928 1    71.67  ? 178 LYS A NZ  1 
ATOM   1462 N  N   . TYR A 1 183 ? -5.52   -17.522 -8.112  1    38.72  ? 179 TYR A N   1 
ATOM   1463 C  CA  . TYR A 1 183 ? -6.682  -17.75  -7.269  1    39.32  ? 179 TYR A CA  1 
ATOM   1464 C  C   . TYR A 1 183 ? -6.571  -19.089 -6.542  1    38.96  ? 179 TYR A C   1 
ATOM   1465 O  O   . TYR A 1 183 ? -6.027  -20.071 -7.06   1    38.59  ? 179 TYR A O   1 
ATOM   1466 C  CB  . TYR A 1 183 ? -7.956  -17.895 -8.09   1    37.67  ? 179 TYR A CB  1 
ATOM   1467 C  CG  . TYR A 1 183 ? -8.239  -16.717 -8.996  1    41.19  ? 179 TYR A CG  1 
ATOM   1468 C  CD1 . TYR A 1 183 ? -8.518  -15.468 -8.454  1    39.37  ? 179 TYR A CD1 1 
ATOM   1469 C  CD2 . TYR A 1 183 ? -8.231  -16.875 -10.384 1    40.9   ? 179 TYR A CD2 1 
ATOM   1470 C  CE1 . TYR A 1 183 ? -8.769  -14.388 -9.287  1    42.52  ? 179 TYR A CE1 1 
ATOM   1471 C  CE2 . TYR A 1 183 ? -8.493  -15.809 -11.22  1    41.24  ? 179 TYR A CE2 1 
ATOM   1472 C  CZ  . TYR A 1 183 ? -8.768  -14.574 -10.665 1    45.01  ? 179 TYR A CZ  1 
ATOM   1473 O  OH  . TYR A 1 183 ? -9.046  -13.546 -11.511 1    48.76  ? 179 TYR A OH  1 
ATOM   1474 N  N   . TYR A 1 184 ? -7.094  -19.08  -5.32   1    36.81  ? 180 TYR A N   1 
ATOM   1475 C  CA  . TYR A 1 184 ? -7.293  -20.298 -4.573  1    38.45  ? 180 TYR A CA  1 
ATOM   1476 C  C   . TYR A 1 184 ? -8.669  -20.192 -3.902  1    36.52  ? 180 TYR A C   1 
ATOM   1477 O  O   . TYR A 1 184 ? -9.201  -19.089 -3.793  1    37.64  ? 180 TYR A O   1 
ATOM   1478 C  CB  . TYR A 1 184 ? -6.127  -20.56  -3.616  1    33.67  ? 180 TYR A CB  1 
ATOM   1479 C  CG  . TYR A 1 184 ? -6.015  -19.531 -2.503  1    36.47  ? 180 TYR A CG  1 
ATOM   1480 C  CD1 . TYR A 1 184 ? -6.896  -19.515 -1.416  1    31.55  ? 180 TYR A CD1 1 
ATOM   1481 C  CD2 . TYR A 1 184 ? -4.979  -18.602 -2.531  1    35.38  ? 180 TYR A CD2 1 
ATOM   1482 C  CE1 . TYR A 1 184 ? -6.728  -18.596 -0.399  1    35.4   ? 180 TYR A CE1 1 
ATOM   1483 C  CE2 . TYR A 1 184 ? -4.792  -17.697 -1.5    1    37.77  ? 180 TYR A CE2 1 
ATOM   1484 C  CZ  . TYR A 1 184 ? -5.673  -17.679 -0.433  1    39.95  ? 180 TYR A CZ  1 
ATOM   1485 O  OH  . TYR A 1 184 ? -5.473  -16.711 0.528   1    40.52  ? 180 TYR A OH  1 
ATOM   1486 N  N   . SER A 1 185 ? -9.211  -21.354 -3.489  1    32.67  ? 181 SER A N   1 
ATOM   1487 C  CA  . SER A 1 185 ? -10.585 -21.425 -3.035  1    37.53  ? 181 SER A CA  1 
ATOM   1488 C  C   . SER A 1 185 ? -10.685 -22.365 -1.846  1    33.54  ? 181 SER A C   1 
ATOM   1489 O  O   . SER A 1 185 ? -9.682  -22.655 -1.217  1    34.75  ? 181 SER A O   1 
ATOM   1490 C  CB  . SER A 1 185 ? -11.55  -21.843 -4.149  1    34.34  ? 181 SER A CB  1 
ATOM   1491 O  OG  . SER A 1 185 ? -12.872 -21.478 -3.767  1    34.49  ? 181 SER A OG  1 
ATOM   1492 N  N   . THR A 1 186 ? -11.905 -22.843 -1.598  1    30.64  ? 182 THR A N   1 
ATOM   1493 C  CA  . THR A 1 186 ? -12.265 -23.665 -0.449  1    31.45  ? 182 THR A CA  1 
ATOM   1494 C  C   . THR A 1 186 ? -11.406 -24.925 -0.409  1    33.06  ? 182 THR A C   1 
ATOM   1495 O  O   . THR A 1 186 ? -11.173 -25.466 0.67    1    32.51  ? 182 THR A O   1 
ATOM   1496 C  CB  . THR A 1 186 ? -13.757 -24.011 -0.567  1    31.19  ? 182 THR A CB  1 
ATOM   1497 O  OG1 . THR A 1 186 ? -13.996 -24.449 -1.91   1    32.22  ? 182 THR A OG1 1 
ATOM   1498 C  CG2 . THR A 1 186 ? -14.667 -22.816 -0.319  1    27.19  ? 182 THR A CG2 1 
ATOM   1499 N  N   . ALA A 1 187 ? -10.914 -25.349 -1.588  1    32.84  ? 183 ALA A N   1 
ATOM   1500 C  CA  . ALA A 1 187 ? -10.116 -26.551 -1.754  1    31.49  ? 183 ALA A CA  1 
ATOM   1501 C  C   . ALA A 1 187 ? -8.853  -26.483 -0.894  1    32.37  ? 183 ALA A C   1 
ATOM   1502 O  O   . ALA A 1 187 ? -8.373  -27.533 -0.515  1    37.84  ? 183 ALA A O   1 
ATOM   1503 C  CB  . ALA A 1 187 ? -9.771  -26.772 -3.207  1    30.03  ? 183 ALA A CB  1 
ATOM   1504 N  N   . VAL A 1 188 ? -8.327  -25.288 -0.582  1    29.68  ? 184 VAL A N   1 
ATOM   1505 C  CA  . VAL A 1 188 ? -7.12   -25.223 0.227   1    32.81  ? 184 VAL A CA  1 
ATOM   1506 C  C   . VAL A 1 188 ? -7.38   -25.743 1.659   1    37.32  ? 184 VAL A C   1 
ATOM   1507 O  O   . VAL A 1 188 ? -6.478  -26.336 2.262   1    37.76  ? 184 VAL A O   1 
ATOM   1508 C  CB  . VAL A 1 188 ? -6.437  -23.843 0.253   1    31.61  ? 184 VAL A CB  1 
ATOM   1509 C  CG1 . VAL A 1 188 ? -6.304  -23.22  -1.136  1    27.73  ? 184 VAL A CG1 1 
ATOM   1510 C  CG2 . VAL A 1 188 ? -7.115  -22.882 1.234   1    30.82  ? 184 VAL A CG2 1 
ATOM   1511 N  N   . ASP A 1 189 ? -8.599  -25.55  2.202   1    34.7   ? 185 ASP A N   1 
ATOM   1512 C  CA  . ASP A 1 189 ? -8.922  -26.044 3.537   1    33.75  ? 185 ASP A CA  1 
ATOM   1513 C  C   . ASP A 1 189 ? -9.074  -27.563 3.485   1    33.32  ? 185 ASP A C   1 
ATOM   1514 O  O   . ASP A 1 189 ? -8.708  -28.265 4.417   1    35.9   ? 185 ASP A O   1 
ATOM   1515 C  CB  . ASP A 1 189 ? -10.137 -25.377 4.173   1    32.67  ? 185 ASP A CB  1 
ATOM   1516 C  CG  . ASP A 1 189 ? -9.982  -23.884 4.431   1    37.56  ? 185 ASP A CG  1 
ATOM   1517 O  OD1 . ASP A 1 189 ? -8.844  -23.48  4.742   1    33.74  ? 185 ASP A OD1 1 
ATOM   1518 O  OD2 . ASP A 1 189 ? -11.011 -23.12  4.319   1    39.74  ? 185 ASP A OD2 1 
ATOM   1519 N  N   . ILE A 1 190 ? -9.577  -28.097 2.384   1    31.18  ? 186 ILE A N   1 
ATOM   1520 C  CA  . ILE A 1 190 ? -9.7    -29.541 2.301   1    35.03  ? 186 ILE A CA  1 
ATOM   1521 C  C   . ILE A 1 190 ? -8.302  -30.166 2.249   1    34.96  ? 186 ILE A C   1 
ATOM   1522 O  O   . ILE A 1 190 ? -8.044  -31.193 2.885   1    34.02  ? 186 ILE A O   1 
ATOM   1523 C  CB  . ILE A 1 190 ? -10.575 -29.968 1.109   1    34.75  ? 186 ILE A CB  1 
ATOM   1524 C  CG1 . ILE A 1 190 ? -12.045 -29.614 1.378   1    36.74  ? 186 ILE A CG1 1 
ATOM   1525 C  CG2 . ILE A 1 190 ? -10.392 -31.445 0.775   1    29.08  ? 186 ILE A CG2 1 
ATOM   1526 C  CD1 . ILE A 1 190 ? -12.706 -30.463 2.443   1    39.41  ? 186 ILE A CD1 1 
ATOM   1527 N  N   . TRP A 1 191 ? -7.398  -29.559 1.483   1    34.66  ? 187 TRP A N   1 
ATOM   1528 C  CA  . TRP A 1 191 ? -6.039  -30.079 1.444   1    36.08  ? 187 TRP A CA  1 
ATOM   1529 C  C   . TRP A 1 191 ? -5.498  -30.214 2.874   1    35.61  ? 187 TRP A C   1 
ATOM   1530 O  O   . TRP A 1 191 ? -5.033  -31.282 3.272   1    38.17  ? 187 TRP A O   1 
ATOM   1531 C  CB  . TRP A 1 191 ? -5.151  -29.184 0.576   1    35.58  ? 187 TRP A CB  1 
ATOM   1532 C  CG  . TRP A 1 191 ? -3.731  -29.682 0.542   1    36.79  ? 187 TRP A CG  1 
ATOM   1533 C  CD1 . TRP A 1 191 ? -2.733  -29.443 1.445   1    34.02  ? 187 TRP A CD1 1 
ATOM   1534 C  CD2 . TRP A 1 191 ? -3.167  -30.531 -0.482  1    34.26  ? 187 TRP A CD2 1 
ATOM   1535 N  NE1 . TRP A 1 191 ? -1.584  -30.093 1.06    1    34.98  ? 187 TRP A NE1 1 
ATOM   1536 C  CE2 . TRP A 1 191 ? -1.82   -30.755 -0.123  1    35.95  ? 187 TRP A CE2 1 
ATOM   1537 C  CE3 . TRP A 1 191 ? -3.657  -31.082 -1.666  1    29.6   ? 187 TRP A CE3 1 
ATOM   1538 C  CZ2 . TRP A 1 191 ? -0.985  -31.55  -0.906  1    32.44  ? 187 TRP A CZ2 1 
ATOM   1539 C  CZ3 . TRP A 1 191 ? -2.813  -31.85  -2.437  1    31.94  ? 187 TRP A CZ3 1 
ATOM   1540 C  CH2 . TRP A 1 191 ? -1.493  -32.092 -2.06   1    29.26  ? 187 TRP A CH2 1 
ATOM   1541 N  N   . SER A 1 192 ? -5.621  -29.137 3.659   1    35.57  ? 188 SER A N   1 
ATOM   1542 C  CA  . SER A 1 192 ? -5.184  -29.113 5.049   1    34.92  ? 188 SER A CA  1 
ATOM   1543 C  C   . SER A 1 192 ? -5.821  -30.259 5.836   1    34.4   ? 188 SER A C   1 
ATOM   1544 O  O   . SER A 1 192 ? -5.142  -31.029 6.49    1    34.23  ? 188 SER A O   1 
ATOM   1545 C  CB  . SER A 1 192 ? -5.439  -27.747 5.654   1    35.26  ? 188 SER A CB  1 
ATOM   1546 O  OG  . SER A 1 192 ? -4.725  -26.75  4.912   1    33.09  ? 188 SER A OG  1 
ATOM   1547 N  N   . LEU A 1 193 ? -7.13   -30.448 5.693   1    39.16  ? 189 LEU A N   1 
ATOM   1548 C  CA  . LEU A 1 193 ? -7.798  -31.517 6.421   1    36.88  ? 189 LEU A CA  1 
ATOM   1549 C  C   . LEU A 1 193 ? -7.302  -32.889 5.977   1    35.63  ? 189 LEU A C   1 
ATOM   1550 O  O   . LEU A 1 193 ? -7.225  -33.798 6.806   1    36.55  ? 189 LEU A O   1 
ATOM   1551 C  CB  . LEU A 1 193 ? -9.304  -31.454 6.262   1    34.11  ? 189 LEU A CB  1 
ATOM   1552 C  CG  . LEU A 1 193 ? -10.02  -30.442 7.139   1    39.98  ? 189 LEU A CG  1 
ATOM   1553 C  CD1 . LEU A 1 193 ? -11.544 -30.736 6.997   1    36.75  ? 189 LEU A CD1 1 
ATOM   1554 C  CD2 . LEU A 1 193 ? -9.513  -30.573 8.588   1    37.49  ? 189 LEU A CD2 1 
ATOM   1555 N  N   . GLY A 1 194 ? -7.009  -33.046 4.675   1    33.27  ? 190 GLY A N   1 
ATOM   1556 C  CA  . GLY A 1 194 ? -6.406  -34.276 4.186   1    33.44  ? 190 GLY A CA  1 
ATOM   1557 C  C   . GLY A 1 194 ? -5.087  -34.594 4.894   1    35.74  ? 190 GLY A C   1 
ATOM   1558 O  O   . GLY A 1 194 ? -4.861  -35.74  5.311   1    34.8   ? 190 GLY A O   1 
ATOM   1559 N  N   . CYS A 1 195 ? -4.221  -33.566 5.023   1    35.04  ? 191 CYS A N   1 
ATOM   1560 C  CA  . CYS A 1 195 ? -2.926  -33.718 5.68    1    33.23  ? 191 CYS A CA  1 
ATOM   1561 C  C   . CYS A 1 195 ? -3.137  -34.134 7.12    1    35.17  ? 191 CYS A C   1 
ATOM   1562 O  O   . CYS A 1 195 ? -2.385  -34.973 7.612   1    35.06  ? 191 CYS A O   1 
ATOM   1563 C  CB  . CYS A 1 195 ? -2.129  -32.429 5.611   1    32.78  ? 191 CYS A CB  1 
ATOM   1564 S  SG  . CYS A 1 195 ? -1.589  -32.024 3.922   1    36     ? 191 CYS A SG  1 
ATOM   1565 N  N   . ILE A 1 196 ? -4.187  -33.563 7.759   1    34.67  ? 192 ILE A N   1 
ATOM   1566 C  CA  . ILE A 1 196 ? -4.514  -33.77  9.162   1    33.82  ? 192 ILE A CA  1 
ATOM   1567 C  C   . ILE A 1 196 ? -5.018  -35.193 9.358   1    37.15  ? 192 ILE A C   1 
ATOM   1568 O  O   . ILE A 1 196 ? -4.654  -35.832 10.355  1    36.13  ? 192 ILE A O   1 
ATOM   1569 C  CB  . ILE A 1 196 ? -5.528  -32.717 9.651   1    35.26  ? 192 ILE A CB  1 
ATOM   1570 C  CG1 . ILE A 1 196 ? -4.807  -31.383 9.739   1    34.43  ? 192 ILE A CG1 1 
ATOM   1571 C  CG2 . ILE A 1 196 ? -6.209  -33.088 10.993  1    30.76  ? 192 ILE A CG2 1 
ATOM   1572 C  CD1 . ILE A 1 196 ? -5.714  -30.193 9.87    1    34.1   ? 192 ILE A CD1 1 
ATOM   1573 N  N   . PHE A 1 197 ? -5.885  -35.639 8.426   1    37.52  ? 193 PHE A N   1 
ATOM   1574 C  CA  . PHE A 1 197 ? -6.41   -37.004 8.393   1    36.57  ? 193 PHE A CA  1 
ATOM   1575 C  C   . PHE A 1 197 ? -5.238  -37.99  8.446   1    39.63  ? 193 PHE A C   1 
ATOM   1576 O  O   . PHE A 1 197 ? -5.179  -38.821 9.356   1    51.85  ? 193 PHE A O   1 
ATOM   1577 C  CB  . PHE A 1 197 ? -7.297  -37.225 7.162   1    32.34  ? 193 PHE A CB  1 
ATOM   1578 C  CG  . PHE A 1 197 ? -7.897  -38.61  6.952   1    31.39  ? 193 PHE A CG  1 
ATOM   1579 C  CD1 . PHE A 1 197 ? -7.933  -39.559 7.963   1    30.24  ? 193 PHE A CD1 1 
ATOM   1580 C  CD2 . PHE A 1 197 ? -8.48   -38.942 5.733   1    30.7   ? 193 PHE A CD2 1 
ATOM   1581 C  CE1 . PHE A 1 197 ? -8.511  -40.796 7.743   1    31.06  ? 193 PHE A CE1 1 
ATOM   1582 C  CE2 . PHE A 1 197 ? -9.083  -40.18  5.52    1    28.25  ? 193 PHE A CE2 1 
ATOM   1583 C  CZ  . PHE A 1 197 ? -9.092  -41.101 6.516   1    30.71  ? 193 PHE A CZ  1 
ATOM   1584 N  N   . ALA A 1 198 ? -4.3    -37.875 7.504   1    35.37  ? 194 ALA A N   1 
ATOM   1585 C  CA  . ALA A 1 198 ? -3.132  -38.757 7.462   1    37.71  ? 194 ALA A CA  1 
ATOM   1586 C  C   . ALA A 1 198 ? -2.366  -38.706 8.784   1    36.9   ? 194 ALA A C   1 
ATOM   1587 O  O   . ALA A 1 198 ? -1.929  -39.737 9.288   1    40.91  ? 194 ALA A O   1 
ATOM   1588 C  CB  . ALA A 1 198 ? -2.227  -38.393 6.301   1    31.19  ? 194 ALA A CB  1 
ATOM   1589 N  N   . GLU A 1 199 ? -2.257  -37.501 9.354   1    35.59  ? 195 GLU A N   1 
ATOM   1590 C  CA  . GLU A 1 199 ? -1.453  -37.257 10.537  1    37.07  ? 195 GLU A CA  1 
ATOM   1591 C  C   . GLU A 1 199 ? -2.101  -37.873 11.779  1    40.17  ? 195 GLU A C   1 
ATOM   1592 O  O   . GLU A 1 199 ? -1.409  -38.339 12.696  1    40.34  ? 195 GLU A O   1 
ATOM   1593 C  CB  . GLU A 1 199 ? -1.184  -35.755 10.657  1    36.97  ? 195 GLU A CB  1 
ATOM   1594 C  CG  . GLU A 1 199 ? -0.262  -35.378 11.818  1    37.11  ? 195 GLU A CG  1 
ATOM   1595 C  CD  . GLU A 1 199 ? 0.201   -33.934 11.857  1    36.22  ? 195 GLU A CD  1 
ATOM   1596 O  OE1 . GLU A 1 199 ? 0.064   -33.248 10.831  1    36.1   ? 195 GLU A OE1 1 
ATOM   1597 O  OE2 . GLU A 1 199 ? 0.719   -33.495 12.899  1    39.08  ? 195 GLU A OE2 1 
ATOM   1598 N  N   . MET A 1 200 ? -3.439  -37.891 11.811  1    41.11  ? 196 MET A N   1 
ATOM   1599 C  CA  . MET A 1 200 ? -4.141  -38.582 12.899  1    39.88  ? 196 MET A CA  1 
ATOM   1600 C  C   . MET A 1 200 ? -3.855  -40.073 12.888  1    37.39  ? 196 MET A C   1 
ATOM   1601 O  O   . MET A 1 200 ? -3.82   -40.679 13.933  1    39.87  ? 196 MET A O   1 
ATOM   1602 C  CB  . MET A 1 200 ? -5.658  -38.352 12.855  1    36.96  ? 196 MET A CB  1 
ATOM   1603 C  CG  . MET A 1 200 ? -6.005  -36.973 13.37   1    36.7   ? 196 MET A CG  1 
ATOM   1604 S  SD  . MET A 1 200 ? -7.773  -36.813 13.625  1    40.58  ? 196 MET A SD  1 
ATOM   1605 C  CE  . MET A 1 200 ? -8.423  -36.755 11.949  1    35.44  ? 196 MET A CE  1 
ATOM   1606 N  N   . VAL A 1 201 ? -3.648  -40.653 11.705  1    39.54  ? 197 VAL A N   1 
ATOM   1607 C  CA  . VAL A 1 201 ? -3.421  -42.09  11.59   1    42.17  ? 197 VAL A CA  1 
ATOM   1608 C  C   . VAL A 1 201 ? -1.985  -42.44  11.995  1    45.74  ? 197 VAL A C   1 
ATOM   1609 O  O   . VAL A 1 201 ? -1.776  -43.372 12.758  1    46.19  ? 197 VAL A O   1 
ATOM   1610 C  CB  . VAL A 1 201 ? -3.73   -42.609 10.173  1    39.97  ? 197 VAL A CB  1 
ATOM   1611 C  CG1 . VAL A 1 201 ? -3.432  -44.086 10.101  1    40.34  ? 197 VAL A CG1 1 
ATOM   1612 C  CG2 . VAL A 1 201 ? -5.179  -42.385 9.768   1    39.78  ? 197 VAL A CG2 1 
ATOM   1613 N  N   . THR A 1 202 ? -1.005  -41.658 11.509  1    47.79  ? 198 THR A N   1 
ATOM   1614 C  CA  . THR A 1 202 ? 0.419   -41.954 11.675  1    48.58  ? 198 THR A CA  1 
ATOM   1615 C  C   . THR A 1 202 ? 1.017   -41.218 12.878  1    48.31  ? 198 THR A C   1 
ATOM   1616 O  O   . THR A 1 202 ? 2.036   -41.643 13.4    1    51.63  ? 198 THR A O   1 
ATOM   1617 C  CB  . THR A 1 202 ? 1.176   -41.597 10.394  1    50.36  ? 198 THR A CB  1 
ATOM   1618 O  OG1 . THR A 1 202 ? 1.191   -40.174 10.275  1    56.13  ? 198 THR A OG1 1 
ATOM   1619 C  CG2 . THR A 1 202 ? 0.537   -42.15  9.132   1    48.62  ? 198 THR A CG2 1 
ATOM   1620 N  N   . ARG A 1 203 ? 0.421   -40.085 13.28   1    47.95  ? 199 ARG A N   1 
ATOM   1621 C  CA  . ARG A 1 203 ? 0.947   -39.238 14.353  1    51.65  ? 199 ARG A CA  1 
ATOM   1622 C  C   . ARG A 1 203 ? 2.214   -38.504 13.916  1    49.17  ? 199 ARG A C   1 
ATOM   1623 O  O   . ARG A 1 203 ? 2.933   -37.972 14.747  1    49.17  ? 199 ARG A O   1 
ATOM   1624 C  CB  . ARG A 1 203 ? 1.14    -39.918 15.721  1    56.82  ? 199 ARG A CB  1 
ATOM   1625 C  CG  . ARG A 1 203 ? -0.135  -40.128 16.535  1    56.74  ? 199 ARG A CG  1 
ATOM   1626 C  CD  . ARG A 1 203 ? -0.066  -41.417 17.335  1    58.77  ? 199 ARG A CD  1 
ATOM   1627 N  NE  . ARG A 1 203 ? -0.139  -42.515 16.363  1    68.32  ? 199 ARG A NE  1 
ATOM   1628 C  CZ  . ARG A 1 203 ? 0.601   -43.625 16.373  1    69.57  ? 199 ARG A CZ  1 
ATOM   1629 N  NH1 . ARG A 1 203 ? 1.444   -43.873 17.367  1    69.12  ? 199 ARG A NH1 1 
ATOM   1630 N  NH2 . ARG A 1 203 ? 0.47    -44.489 15.381  1    67.64  ? 199 ARG A NH2 1 
ATOM   1631 N  N   . ARG A 1 204 ? 2.445   -38.424 12.604  1    47.46  ? 200 ARG A N   1 
ATOM   1632 C  CA  . ARG A 1 204 ? 3.524   -37.615 12.061  1    48.22  ? 200 ARG A CA  1 
ATOM   1633 C  C   . ARG A 1 204 ? 2.999   -36.848 10.854  1    46.51  ? 200 ARG A C   1 
ATOM   1634 O  O   . ARG A 1 204 ? 2.159   -37.349 10.113  1    50.22  ? 200 ARG A O   1 
ATOM   1635 C  CB  . ARG A 1 204 ? 4.749   -38.48  11.787  1    48.56  ? 200 ARG A CB  1 
ATOM   1636 C  CG  . ARG A 1 204 ? 4.472   -39.535 10.735  1    62.13  ? 200 ARG A CG  1 
ATOM   1637 C  CD  . ARG A 1 204 ? 5.735   -40.33  10.315  1    68.95  ? 200 ARG A CD  1 
ATOM   1638 N  NE  . ARG A 1 204 ? 5.623   -40.713 8.898   1    67.87  ? 200 ARG A NE  1 
ATOM   1639 C  CZ  . ARG A 1 204 ? 6.555   -41.354 8.184   1    71.29  ? 200 ARG A CZ  1 
ATOM   1640 N  NH1 . ARG A 1 204 ? 7.693   -41.733 8.757   1    75.14  ? 200 ARG A NH1 1 
ATOM   1641 N  NH2 . ARG A 1 204 ? 6.337   -41.636 6.909   1    60.03  ? 200 ARG A NH2 1 
ATOM   1642 N  N   . ALA A 1 205 ? 3.496   -35.626 10.67   1    45.07  ? 201 ALA A N   1 
ATOM   1643 C  CA  . ALA A 1 205 ? 3.08    -34.804 9.541   1    41.82  ? 201 ALA A CA  1 
ATOM   1644 C  C   . ALA A 1 205 ? 3.35    -35.538 8.221   1    43.05  ? 201 ALA A C   1 
ATOM   1645 O  O   . ALA A 1 205 ? 4.388   -36.177 8.061   1    45.54  ? 201 ALA A O   1 
ATOM   1646 C  CB  . ALA A 1 205 ? 3.75    -33.45  9.628   1    37.47  ? 201 ALA A CB  1 
ATOM   1647 N  N   . LEU A 1 206 ? 2.39    -35.464 7.302   1    39.59  ? 202 LEU A N   1 
ATOM   1648 C  CA  . LEU A 1 206 ? 2.484   -36.123 6.013   1    43.79  ? 202 LEU A CA  1 
ATOM   1649 C  C   . LEU A 1 206 ? 3.543   -35.465 5.119   1    45.74  ? 202 LEU A C   1 
ATOM   1650 O  O   . LEU A 1 206 ? 4.245   -36.175 4.409   1    47.59  ? 202 LEU A O   1 
ATOM   1651 C  CB  . LEU A 1 206 ? 1.107   -36.098 5.342   1    38.53  ? 202 LEU A CB  1 
ATOM   1652 C  CG  . LEU A 1 206 ? 1.007   -36.811 3.98    1    42.28  ? 202 LEU A CG  1 
ATOM   1653 C  CD1 . LEU A 1 206 ? 1.253   -38.315 4.119   1    42.58  ? 202 LEU A CD1 1 
ATOM   1654 C  CD2 . LEU A 1 206 ? -0.352  -36.601 3.366   1    41.37  ? 202 LEU A CD2 1 
ATOM   1655 N  N   . PHE A 1 207 ? 3.625   -34.115 5.1     1    42.31  ? 203 PHE A N   1 
ATOM   1656 C  CA  . PHE A 1 207 ? 4.615   -33.459 4.251   1    37.39  ? 203 PHE A CA  1 
ATOM   1657 C  C   . PHE A 1 207 ? 5.364   -32.385 5.03    1    40.03  ? 203 PHE A C   1 
ATOM   1658 O  O   . PHE A 1 207 ? 5.032   -31.194 4.929   1    46.1   ? 203 PHE A O   1 
ATOM   1659 C  CB  . PHE A 1 207 ? 4       -32.739 3.061   1    34.33  ? 203 PHE A CB  1 
ATOM   1660 C  CG  . PHE A 1 207 ? 3.045   -33.591 2.248   1    36.8   ? 203 PHE A CG  1 
ATOM   1661 C  CD1 . PHE A 1 207 ? 3.541   -34.667 1.519   1    37.2   ? 203 PHE A CD1 1 
ATOM   1662 C  CD2 . PHE A 1 207 ? 1.68    -33.303 2.199   1    33.95  ? 203 PHE A CD2 1 
ATOM   1663 C  CE1 . PHE A 1 207 ? 2.687   -35.441 0.769   1    36.5   ? 203 PHE A CE1 1 
ATOM   1664 C  CE2 . PHE A 1 207 ? 0.835   -34.087 1.442   1    35.75  ? 203 PHE A CE2 1 
ATOM   1665 C  CZ  . PHE A 1 207 ? 1.342   -35.14  0.704   1    34.85  ? 203 PHE A CZ  1 
ATOM   1666 N  N   . PRO A 1 208 ? 6.369   -32.76  5.852   1    38.92  ? 204 PRO A N   1 
ATOM   1667 C  CA  . PRO A 1 208 ? 7.092   -31.774 6.658   1    37.77  ? 204 PRO A CA  1 
ATOM   1668 C  C   . PRO A 1 208 ? 8.229   -31.108 5.889   1    40.17  ? 204 PRO A C   1 
ATOM   1669 O  O   . PRO A 1 208 ? 9.398   -31.424 6.113   1    42.68  ? 204 PRO A O   1 
ATOM   1670 C  CB  . PRO A 1 208 ? 7.61    -32.694 7.803   1    38.23  ? 204 PRO A CB  1 
ATOM   1671 C  CG  . PRO A 1 208 ? 7.933   -34.033 7.139   1    35.71  ? 204 PRO A CG  1 
ATOM   1672 C  CD  . PRO A 1 208 ? 6.826   -34.152 6.081   1    37.13  ? 204 PRO A CD  1 
ATOM   1673 N  N   . GLY A 1 209 ? 7.891   -30.191 4.979   1    41.3   ? 205 GLY A N   1 
ATOM   1674 C  CA  . GLY A 1 209 ? 8.913   -29.466 4.235   1    43.4   ? 205 GLY A CA  1 
ATOM   1675 C  C   . GLY A 1 209 ? 9.66    -28.465 5.123   1    47.77  ? 205 GLY A C   1 
ATOM   1676 O  O   . GLY A 1 209 ? 9.137   -28.079 6.155   1    52.24  ? 205 GLY A O   1 
ATOM   1677 N  N   . ASP A 1 210 ? 10.882  -28.047 4.736   1    53.68  ? 206 ASP A N   1 
ATOM   1678 C  CA  . ASP A 1 210 ? 11.568  -26.971 5.447   1    57.24  ? 206 ASP A CA  1 
ATOM   1679 C  C   . ASP A 1 210 ? 11.737  -25.754 4.553   1    54.38  ? 206 ASP A C   1 
ATOM   1680 O  O   . ASP A 1 210 ? 12.472  -24.849 4.923   1    59.34  ? 206 ASP A O   1 
ATOM   1681 C  CB  . ASP A 1 210 ? 12.886  -27.427 6.045   1    69.79  ? 206 ASP A CB  1 
ATOM   1682 C  CG  . ASP A 1 210 ? 13.85   -27.906 4.978   1    79.43  ? 206 ASP A CG  1 
ATOM   1683 O  OD1 . ASP A 1 210 ? 13.41   -27.932 3.814   1    90.7   ? 206 ASP A OD1 1 
ATOM   1684 O  OD2 . ASP A 1 210 ? 14.985  -28.308 5.335   1    74.56  ? 206 ASP A OD2 1 
ATOM   1685 N  N   . SER A 1 211 ? 11.026  -25.728 3.409   1    48.55  ? 207 SER A N   1 
ATOM   1686 C  CA  . SER A 1 211 ? 11.013  -24.578 2.524   1    44.93  ? 207 SER A CA  1 
ATOM   1687 C  C   . SER A 1 211 ? 9.875   -24.756 1.544   1    44.48  ? 207 SER A C   1 
ATOM   1688 O  O   . SER A 1 211 ? 9.303   -25.828 1.479   1    46.47  ? 207 SER A O   1 
ATOM   1689 C  CB  . SER A 1 211 ? 12.332  -24.43  1.819   1    48.66  ? 207 SER A CB  1 
ATOM   1690 O  OG  . SER A 1 211 ? 12.637  -25.59  1.063   1    47.65  ? 207 SER A OG  1 
ATOM   1691 N  N   . GLU A 1 212 ? 9.519   -23.713 0.786   1    46.86  ? 208 GLU A N   1 
ATOM   1692 C  CA  . GLU A 1 212 ? 8.461   -23.872 -0.205  1    45.21  ? 208 GLU A CA  1 
ATOM   1693 C  C   . GLU A 1 212 ? 8.809   -24.949 -1.232  1    41.91  ? 208 GLU A C   1 
ATOM   1694 O  O   . GLU A 1 212 ? 8.023   -25.842 -1.489  1    39.59  ? 208 GLU A O   1 
ATOM   1695 C  CB  . GLU A 1 212 ? 8.216   -22.543 -0.91   1    49.42  ? 208 GLU A CB  1 
ATOM   1696 C  CG  . GLU A 1 212 ? 7.346   -21.623 -0.057  1    53.13  ? 208 GLU A CG  1 
ATOM   1697 C  CD  . GLU A 1 212 ? 7.103   -20.279 -0.697  1    56.51  ? 208 GLU A CD  1 
ATOM   1698 O  OE1 . GLU A 1 212 ? 6.299   -20.177 -1.648  1    61.01  ? 208 GLU A OE1 1 
ATOM   1699 O  OE2 . GLU A 1 212 ? 7.797   -19.348 -0.275  1    64.32  ? 208 GLU A OE2 1 
ATOM   1700 N  N   . ILE A 1 213 ? 10.017  -24.905 -1.787  1    42.97  ? 209 ILE A N   1 
ATOM   1701 C  CA  . ILE A 1 213 ? 10.354  -25.877 -2.812  1    41.89  ? 209 ILE A CA  1 
ATOM   1702 C  C   . ILE A 1 213 ? 10.455  -27.302 -2.233  1    41.03  ? 209 ILE A C   1 
ATOM   1703 O  O   . ILE A 1 213 ? 10.043  -28.272 -2.875  1    41.08  ? 209 ILE A O   1 
ATOM   1704 C  CB  . ILE A 1 213 ? 11.606  -25.427 -3.58   1    42.53  ? 209 ILE A CB  1 
ATOM   1705 C  CG1 . ILE A 1 213 ? 11.734  -26.179 -4.886  1    42.55  ? 209 ILE A CG1 1 
ATOM   1706 C  CG2 . ILE A 1 213 ? 12.852  -25.567 -2.715  1    46.15  ? 209 ILE A CG2 1 
ATOM   1707 C  CD1 . ILE A 1 213 ? 10.623  -25.841 -5.875  1    42.63  ? 209 ILE A CD1 1 
ATOM   1708 N  N   . ASP A 1 214 ? 10.996  -27.446 -1.016  1    41.33  ? 210 ASP A N   1 
ATOM   1709 C  CA  . ASP A 1 214 ? 11.067  -28.742 -0.373  1    39.48  ? 210 ASP A CA  1 
ATOM   1710 C  C   . ASP A 1 214 ? 9.677   -29.289 -0.057  1    39.59  ? 210 ASP A C   1 
ATOM   1711 O  O   . ASP A 1 214 ? 9.447   -30.49  -0.195  1    42.45  ? 210 ASP A O   1 
ATOM   1712 C  CB  . ASP A 1 214 ? 11.875  -28.689 0.893   1    41.66  ? 210 ASP A CB  1 
ATOM   1713 C  CG  . ASP A 1 214 ? 12.067  -30.05  1.533   1    46.12  ? 210 ASP A CG  1 
ATOM   1714 O  OD1 . ASP A 1 214 ? 12.611  -30.983 0.821   1    49.15  ? 210 ASP A OD1 1 
ATOM   1715 O  OD2 . ASP A 1 214 ? 11.668  -30.156 2.724   1    43.44  ? 210 ASP A OD2 1 
ATOM   1716 N  N   . GLN A 1 215 ? 8.752   -28.412 0.364   1    36.7   ? 211 GLN A N   1 
ATOM   1717 C  CA  . GLN A 1 215 ? 7.366   -28.776 0.593   1    35.6   ? 211 GLN A CA  1 
ATOM   1718 C  C   . GLN A 1 215 ? 6.78    -29.375 -0.683  1    35.19  ? 211 GLN A C   1 
ATOM   1719 O  O   . GLN A 1 215 ? 6.253   -30.476 -0.64   1    39.06  ? 211 GLN A O   1 
ATOM   1720 C  CB  . GLN A 1 215 ? 6.544   -27.564 1.043   1    36.96  ? 211 GLN A CB  1 
ATOM   1721 C  CG  . GLN A 1 215 ? 5.124   -27.902 1.485   1    34.49  ? 211 GLN A CG  1 
ATOM   1722 C  CD  . GLN A 1 215 ? 5.151   -28.775 2.721   1    38.55  ? 211 GLN A CD  1 
ATOM   1723 O  OE1 . GLN A 1 215 ? 6.085   -28.719 3.538   1    38.12  ? 211 GLN A OE1 1 
ATOM   1724 N  NE2 . GLN A 1 215 ? 4.13    -29.609 2.868   1    36.25  ? 211 GLN A NE2 1 
ATOM   1725 N  N   . LEU A 1 216 ? 6.891   -28.666 -1.815  1    34.86  ? 212 LEU A N   1 
ATOM   1726 C  CA  . LEU A 1 216 ? 6.408   -29.158 -3.097  1    35.89  ? 212 LEU A CA  1 
ATOM   1727 C  C   . LEU A 1 216 ? 7.032   -30.502 -3.439  1    38.01  ? 212 LEU A C   1 
ATOM   1728 O  O   . LEU A 1 216 ? 6.33    -31.401 -3.92   1    37.2   ? 212 LEU A O   1 
ATOM   1729 C  CB  . LEU A 1 216 ? 6.767   -28.198 -4.225  1    36.72  ? 212 LEU A CB  1 
ATOM   1730 C  CG  . LEU A 1 216 ? 5.785   -27.07  -4.487  1    40.75  ? 212 LEU A CG  1 
ATOM   1731 C  CD1 . LEU A 1 216 ? 6.453   -26.192 -5.574  1    46.65  ? 212 LEU A CD1 1 
ATOM   1732 C  CD2 . LEU A 1 216 ? 4.414   -27.624 -4.914  1    35.02  ? 212 LEU A CD2 1 
ATOM   1733 N  N   . PHE A 1 217 ? 8.367   -30.557 -3.306  1    35     ? 213 PHE A N   1 
ATOM   1734 C  CA  . PHE A 1 217 ? 9.088   -31.739 -3.707  1    35.83  ? 213 PHE A CA  1 
ATOM   1735 C  C   . PHE A 1 217 ? 8.587   -32.917 -2.882  1    37.17  ? 213 PHE A C   1 
ATOM   1736 O  O   . PHE A 1 217 ? 8.394   -33.986 -3.435  1    44.43  ? 213 PHE A O   1 
ATOM   1737 C  CB  . PHE A 1 217 ? 10.616  -31.56  -3.668  1    36.43  ? 213 PHE A CB  1 
ATOM   1738 C  CG  . PHE A 1 217 ? 11.145  -30.804 -4.866  1    36.21  ? 213 PHE A CG  1 
ATOM   1739 C  CD1 . PHE A 1 217 ? 10.269  -30.224 -5.781  1    34.15  ? 213 PHE A CD1 1 
ATOM   1740 C  CD2 . PHE A 1 217 ? 12.513  -30.622 -5.035  1    37.97  ? 213 PHE A CD2 1 
ATOM   1741 C  CE1 . PHE A 1 217 ? 10.763  -29.497 -6.846  1    35.81  ? 213 PHE A CE1 1 
ATOM   1742 C  CE2 . PHE A 1 217 ? 13.004  -29.902 -6.117  1    37.12  ? 213 PHE A CE2 1 
ATOM   1743 C  CZ  . PHE A 1 217 ? 12.127  -29.344 -7.021  1    36.07  ? 213 PHE A CZ  1 
ATOM   1744 N  N   . ARG A 1 218 ? 8.342   -32.732 -1.586  1    35.42  ? 214 ARG A N   1 
ATOM   1745 C  CA  . ARG A 1 218 ? 7.886   -33.848 -0.774  1    37.19  ? 214 ARG A CA  1 
ATOM   1746 C  C   . ARG A 1 218 ? 6.493   -34.289 -1.215  1    36.37  ? 214 ARG A C   1 
ATOM   1747 O  O   . ARG A 1 218 ? 6.209   -35.481 -1.178  1    38.79  ? 214 ARG A O   1 
ATOM   1748 C  CB  . ARG A 1 218 ? 7.837   -33.476 0.722   1    38.34  ? 214 ARG A CB  1 
ATOM   1749 C  CG  . ARG A 1 218 ? 9.209   -33.353 1.371   1    39.82  ? 214 ARG A CG  1 
ATOM   1750 C  CD  . ARG A 1 218 ? 9.045   -32.828 2.769   1    43.01  ? 214 ARG A CD  1 
ATOM   1751 N  NE  . ARG A 1 218 ? 10.356  -32.647 3.387   1    44.98  ? 214 ARG A NE  1 
ATOM   1752 C  CZ  . ARG A 1 218 ? 10.891  -33.557 4.197   1    45.97  ? 214 ARG A CZ  1 
ATOM   1753 N  NH1 . ARG A 1 218 ? 10.242  -34.698 4.378   1    43.48  ? 214 ARG A NH1 1 
ATOM   1754 N  NH2 . ARG A 1 218 ? 12.056  -33.31  4.786   1    41.29  ? 214 ARG A NH2 1 
ATOM   1755 N  N   . ILE A 1 219 ? 5.626   -33.325 -1.554  1    33.67  ? 215 ILE A N   1 
ATOM   1756 C  CA  . ILE A 1 219 ? 4.291   -33.625 -2.046  1    35.16  ? 215 ILE A CA  1 
ATOM   1757 C  C   . ILE A 1 219 ? 4.364   -34.439 -3.344  1    36.34  ? 215 ILE A C   1 
ATOM   1758 O  O   . ILE A 1 219 ? 3.735   -35.498 -3.425  1    37.56  ? 215 ILE A O   1 
ATOM   1759 C  CB  . ILE A 1 219 ? 3.454   -32.355 -2.246  1    33.25  ? 215 ILE A CB  1 
ATOM   1760 C  CG1 . ILE A 1 219 ? 3.21    -31.646 -0.903  1    33.85  ? 215 ILE A CG1 1 
ATOM   1761 C  CG2 . ILE A 1 219 ? 2.131   -32.718 -2.941  1    30.46  ? 215 ILE A CG2 1 
ATOM   1762 C  CD1 . ILE A 1 219 ? 2.5     -30.297 -1.029  1    32.66  ? 215 ILE A CD1 1 
ATOM   1763 N  N   . PHE A 1 220 ? 5.129   -33.93  -4.324  1    33.09  ? 216 PHE A N   1 
ATOM   1764 C  CA  . PHE A 1 220 ? 5.39    -34.58  -5.601  1    33.41  ? 216 PHE A CA  1 
ATOM   1765 C  C   . PHE A 1 220 ? 5.969   -35.991 -5.429  1    33     ? 216 PHE A C   1 
ATOM   1766 O  O   . PHE A 1 220 ? 5.636   -36.88  -6.202  1    32.02  ? 216 PHE A O   1 
ATOM   1767 C  CB  . PHE A 1 220 ? 6.408   -33.807 -6.445  1    33.19  ? 216 PHE A CB  1 
ATOM   1768 C  CG  . PHE A 1 220 ? 5.956   -32.451 -6.96   1    33.25  ? 216 PHE A CG  1 
ATOM   1769 C  CD1 . PHE A 1 220 ? 4.655   -31.998 -6.74   1    31.52  ? 216 PHE A CD1 1 
ATOM   1770 C  CD2 . PHE A 1 220 ? 6.823   -31.66  -7.712  1    34.18  ? 216 PHE A CD2 1 
ATOM   1771 C  CE1 . PHE A 1 220 ? 4.262   -30.742 -7.199  1    32.87  ? 216 PHE A CE1 1 
ATOM   1772 C  CE2 . PHE A 1 220 ? 6.399   -30.425 -8.199  1    35.5   ? 216 PHE A CE2 1 
ATOM   1773 C  CZ  . PHE A 1 220 ? 5.139   -29.949 -7.928  1    32.31  ? 216 PHE A CZ  1 
ATOM   1774 N  N   . ARG A 1 221 ? 6.849   -36.206 -4.454  1    31.53  ? 217 ARG A N   1 
ATOM   1775 C  CA  . ARG A 1 221 ? 7.449   -37.525 -4.3    1    34.59  ? 217 ARG A CA  1 
ATOM   1776 C  C   . ARG A 1 221 ? 6.453   -38.533 -3.736  1    36.34  ? 217 ARG A C   1 
ATOM   1777 O  O   . ARG A 1 221 ? 6.716   -39.719 -3.802  1    40.44  ? 217 ARG A O   1 
ATOM   1778 C  CB  . ARG A 1 221 ? 8.684   -37.572 -3.404  1    34.4   ? 217 ARG A CB  1 
ATOM   1779 C  CG  . ARG A 1 221 ? 9.925   -37.036 -4.108  1    37.18  ? 217 ARG A CG  1 
ATOM   1780 C  CD  . ARG A 1 221 ? 11.233  -37.444 -3.438  1    39.93  ? 217 ARG A CD  1 
ATOM   1781 N  NE  . ARG A 1 221 ? 11.391  -36.665 -2.218  1    42.81  ? 217 ARG A NE  1 
ATOM   1782 C  CZ  . ARG A 1 221 ? 11.836  -35.428 -2.054  1    43.14  ? 217 ARG A CZ  1 
ATOM   1783 N  NH1 . ARG A 1 221 ? 11.775  -34.893 -0.846  1    42.43  ? 217 ARG A NH1 1 
ATOM   1784 N  NH2 . ARG A 1 221 ? 12.358  -34.771 -3.062  1    42.58  ? 217 ARG A NH2 1 
ATOM   1785 N  N   . THR A 1 222 ? 5.343   -38.066 -3.167  1    35.46  ? 218 THR A N   1 
ATOM   1786 C  CA  . THR A 1 222 ? 4.352   -38.939 -2.565  1    39.1   ? 218 THR A CA  1 
ATOM   1787 C  C   . THR A 1 222 ? 3.208   -39.19  -3.551  1    41.1   ? 218 THR A C   1 
ATOM   1788 O  O   . THR A 1 222 ? 2.754   -40.324 -3.715  1    43.25  ? 218 THR A O   1 
ATOM   1789 C  CB  . THR A 1 222 ? 3.791   -38.306 -1.286  1    37.86  ? 218 THR A CB  1 
ATOM   1790 O  OG1 . THR A 1 222 ? 4.867   -38.216 -0.362  1    41     ? 218 THR A OG1 1 
ATOM   1791 C  CG2 . THR A 1 222 ? 2.719   -39.158 -0.639  1    38.59  ? 218 THR A CG2 1 
ATOM   1792 N  N   . LEU A 1 223 ? 2.75    -38.107 -4.178  1    37.74  ? 219 LEU A N   1 
ATOM   1793 C  CA  . LEU A 1 223 ? 1.564   -38.135 -4.99   1    39.51  ? 219 LEU A CA  1 
ATOM   1794 C  C   . LEU A 1 223 ? 1.916   -38.151 -6.469  1    40.8   ? 219 LEU A C   1 
ATOM   1795 O  O   . LEU A 1 223 ? 0.983   -38.168 -7.283  1    42.66  ? 219 LEU A O   1 
ATOM   1796 C  CB  . LEU A 1 223 ? 0.753   -36.883 -4.671  1    37.43  ? 219 LEU A CB  1 
ATOM   1797 C  CG  . LEU A 1 223 ? 0.26    -36.736 -3.224  1    35.4   ? 219 LEU A CG  1 
ATOM   1798 C  CD1 . LEU A 1 223 ? -0.65   -35.537 -3.104  1    32.25  ? 219 LEU A CD1 1 
ATOM   1799 C  CD2 . LEU A 1 223 ? -0.504  -37.943 -2.778  1    39.23  ? 219 LEU A CD2 1 
ATOM   1800 N  N   . GLY A 1 224 ? 3.22    -38.08  -6.789  1    37.4   ? 220 GLY A N   1 
ATOM   1801 C  CA  . GLY A 1 224 ? 3.715   -37.989 -8.159  1    35.64  ? 220 GLY A CA  1 
ATOM   1802 C  C   . GLY A 1 224 ? 3.808   -36.531 -8.601  1    36.74  ? 220 GLY A C   1 
ATOM   1803 O  O   . GLY A 1 224 ? 3.102   -35.68  -8.058  1    36.72  ? 220 GLY A O   1 
ATOM   1804 N  N   . THR A 1 225 ? 4.702   -36.226 -9.558  1    35.77  ? 221 THR A N   1 
ATOM   1805 C  CA  . THR A 1 225 ? 4.83    -34.843 -10.012 1    35.57  ? 221 THR A CA  1 
ATOM   1806 C  C   . THR A 1 225 ? 3.687   -34.604 -10.988 1    38.17  ? 221 THR A C   1 
ATOM   1807 O  O   . THR A 1 225 ? 3.551   -35.347 -11.966 1    39.7   ? 221 THR A O   1 
ATOM   1808 C  CB  . THR A 1 225 ? 6.169   -34.591 -10.716 1    37.54  ? 221 THR A CB  1 
ATOM   1809 O  OG1 . THR A 1 225 ? 7.248   -34.956 -9.873  1    39.52  ? 221 THR A OG1 1 
ATOM   1810 C  CG2 . THR A 1 225 ? 6.323   -33.166 -11.227 1    34.57  ? 221 THR A CG2 1 
ATOM   1811 N  N   . PRO A 1 226 ? 2.827   -33.594 -10.763 1    40.49  ? 222 PRO A N   1 
ATOM   1812 C  CA  . PRO A 1 226 ? 1.634   -33.41  -11.603 1    39.27  ? 222 PRO A CA  1 
ATOM   1813 C  C   . PRO A 1 226 ? 2.008   -32.905 -12.988 1    40.44  ? 222 PRO A C   1 
ATOM   1814 O  O   . PRO A 1 226 ? 2.996   -32.198 -13.149 1    41.54  ? 222 PRO A O   1 
ATOM   1815 C  CB  . PRO A 1 226 ? 0.839   -32.384 -10.804 1    41.99  ? 222 PRO A CB  1 
ATOM   1816 C  CG  . PRO A 1 226 ? 1.931   -31.562 -10.093 1    41.03  ? 222 PRO A CG  1 
ATOM   1817 C  CD  . PRO A 1 226 ? 2.951   -32.604 -9.68   1    39.83  ? 222 PRO A CD  1 
ATOM   1818 N  N   . ASP A 1 227 ? 1.273   -33.392 -13.991 1    44.29  ? 223 ASP A N   1 
ATOM   1819 C  CA  . ASP A 1 227 ? 1.38    -32.989 -15.389 1    45.99  ? 223 ASP A CA  1 
ATOM   1820 C  C   . ASP A 1 227 ? 0.007   -32.458 -15.844 1    47.52  ? 223 ASP A C   1 
ATOM   1821 O  O   . ASP A 1 227 ? -0.975  -32.424 -15.07  1    40.88  ? 223 ASP A O   1 
ATOM   1822 C  CB  . ASP A 1 227 ? 1.867   -34.166 -16.228 1    46.87  ? 223 ASP A CB  1 
ATOM   1823 C  CG  . ASP A 1 227 ? 0.929   -35.375 -16.265 1    57     ? 223 ASP A CG  1 
ATOM   1824 O  OD1 . ASP A 1 227 ? -0.299  -35.237 -16.005 1    56.5   ? 223 ASP A OD1 1 
ATOM   1825 O  OD2 . ASP A 1 227 ? 1.408   -36.471 -16.581 1    61.48  ? 223 ASP A OD2 1 
ATOM   1826 N  N   . GLU A 1 228 ? -0.064  -32.116 -17.144 1    48.24  ? 224 GLU A N   1 
ATOM   1827 C  CA  . GLU A 1 228 ? -1.254  -31.528 -17.746 1    46.53  ? 224 GLU A CA  1 
ATOM   1828 C  C   . GLU A 1 228 ? -2.45   -32.482 -17.665 1    48.42  ? 224 GLU A C   1 
ATOM   1829 O  O   . GLU A 1 228 ? -3.587  -32.042 -17.459 1    51.66  ? 224 GLU A O   1 
ATOM   1830 C  CB  . GLU A 1 228 ? -0.92   -31.076 -19.167 1    46.67  ? 224 GLU A CB  1 
ATOM   1831 C  CG  . GLU A 1 228 ? -0.125  -29.775 -19.202 1    47.99  ? 224 GLU A CG  1 
ATOM   1832 C  CD  . GLU A 1 228 ? -0.845  -28.547 -18.638 1    51.03  ? 224 GLU A CD  1 
ATOM   1833 O  OE1 . GLU A 1 228 ? -2.085  -28.474 -18.702 1    50.12  ? 224 GLU A OE1 1 
ATOM   1834 O  OE2 . GLU A 1 228 ? -0.169  -27.653 -18.092 1    51.58  ? 224 GLU A OE2 1 
ATOM   1835 N  N   . VAL A 1 229 ? -2.184  -33.789 -17.774 1    47.43  ? 225 VAL A N   1 
ATOM   1836 C  CA  . VAL A 1 229 ? -3.224  -34.799 -17.662 1    50.77  ? 225 VAL A CA  1 
ATOM   1837 C  C   . VAL A 1 229 ? -3.891  -34.788 -16.279 1    53.51  ? 225 VAL A C   1 
ATOM   1838 O  O   . VAL A 1 229 ? -5.103  -34.657 -16.183 1    54.53  ? 225 VAL A O   1 
ATOM   1839 C  CB  . VAL A 1 229 ? -2.674  -36.196 -17.992 1    54.5   ? 225 VAL A CB  1 
ATOM   1840 C  CG1 . VAL A 1 229 ? -3.731  -37.267 -17.752 1    54.11  ? 225 VAL A CG1 1 
ATOM   1841 C  CG2 . VAL A 1 229 ? -2.127  -36.258 -19.418 1    55.48  ? 225 VAL A CG2 1 
ATOM   1842 N  N   . VAL A 1 230 ? -3.123  -34.94  -15.193 1    48.79  ? 226 VAL A N   1 
ATOM   1843 C  CA  . VAL A 1 230 ? -3.752  -35.023 -13.89  1    43.98  ? 226 VAL A CA  1 
ATOM   1844 C  C   . VAL A 1 230 ? -4.286  -33.648 -13.499 1    44.63  ? 226 VAL A C   1 
ATOM   1845 O  O   . VAL A 1 230 ? -5.239  -33.548 -12.727 1    47.57  ? 226 VAL A O   1 
ATOM   1846 C  CB  . VAL A 1 230 ? -2.735  -35.568 -12.865 1    45.78  ? 226 VAL A CB  1 
ATOM   1847 C  CG1 . VAL A 1 230 ? -1.531  -34.659 -12.756 1    50.83  ? 226 VAL A CG1 1 
ATOM   1848 C  CG2 . VAL A 1 230 ? -3.313  -35.726 -11.474 1    47.72  ? 226 VAL A CG2 1 
ATOM   1849 N  N   . TRP A 1 231 ? -3.62   -32.574 -13.945 1    46.21  ? 227 TRP A N   1 
ATOM   1850 C  CA  . TRP A 1 231 ? -3.927  -31.241 -13.433 1    42.03  ? 227 TRP A CA  1 
ATOM   1851 C  C   . TRP A 1 231 ? -3.783  -30.231 -14.568 1    43.01  ? 227 TRP A C   1 
ATOM   1852 O  O   . TRP A 1 231 ? -2.735  -29.63  -14.73  1    46.4   ? 227 TRP A O   1 
ATOM   1853 C  CB  . TRP A 1 231 ? -3.042  -30.896 -12.221 1    38.67  ? 227 TRP A CB  1 
ATOM   1854 C  CG  . TRP A 1 231 ? -3.344  -29.586 -11.53  1    41.47  ? 227 TRP A CG  1 
ATOM   1855 C  CD1 . TRP A 1 231 ? -4.346  -28.71  -11.821 1    43.01  ? 227 TRP A CD1 1 
ATOM   1856 C  CD2 . TRP A 1 231 ? -2.65   -29.003 -10.407 1    41.44  ? 227 TRP A CD2 1 
ATOM   1857 N  NE1 . TRP A 1 231 ? -4.322  -27.639 -10.983 1    38.95  ? 227 TRP A NE1 1 
ATOM   1858 C  CE2 . TRP A 1 231 ? -3.296  -27.786 -10.101 1    38.44  ? 227 TRP A CE2 1 
ATOM   1859 C  CE3 . TRP A 1 231 ? -1.533  -29.376 -9.648  1    42.36  ? 227 TRP A CE3 1 
ATOM   1860 C  CZ2 . TRP A 1 231 ? -2.89   -26.955 -9.059  1    35     ? 227 TRP A CZ2 1 
ATOM   1861 C  CZ3 . TRP A 1 231 ? -1.118  -28.546 -8.629  1    40.58  ? 227 TRP A CZ3 1 
ATOM   1862 C  CH2 . TRP A 1 231 ? -1.803  -27.373 -8.324  1    39.65  ? 227 TRP A CH2 1 
ATOM   1863 N  N   . PRO A 1 232 ? -4.808  -30.024 -15.415 1    47.12  ? 228 PRO A N   1 
ATOM   1864 C  CA  . PRO A 1 232 ? -4.692  -29.079 -16.54  1    49.26  ? 228 PRO A CA  1 
ATOM   1865 C  C   . PRO A 1 232 ? -4.385  -27.654 -16.052 1    48.51  ? 228 PRO A C   1 
ATOM   1866 O  O   . PRO A 1 232 ? -4.955  -27.205 -15.038 1    41.53  ? 228 PRO A O   1 
ATOM   1867 C  CB  . PRO A 1 232 ? -6.061  -29.169 -17.253 1    48.07  ? 228 PRO A CB  1 
ATOM   1868 C  CG  . PRO A 1 232 ? -6.707  -30.433 -16.69  1    45.11  ? 228 PRO A CG  1 
ATOM   1869 C  CD  . PRO A 1 232 ? -6.138  -30.652 -15.31  1    47.35  ? 228 PRO A CD  1 
ATOM   1870 N  N   . GLY A 1 233 ? -3.431  -26.989 -16.749 1    47.99  ? 229 GLY A N   1 
ATOM   1871 C  CA  . GLY A 1 233 ? -2.945  -25.67  -16.347 1    48.77  ? 229 GLY A CA  1 
ATOM   1872 C  C   . GLY A 1 233 ? -1.671  -25.693 -15.479 1    55.77  ? 229 GLY A C   1 
ATOM   1873 O  O   . GLY A 1 233 ? -0.975  -24.683 -15.355 1    66.53  ? 229 GLY A O   1 
ATOM   1874 N  N   . VAL A 1 234 ? -1.333  -26.842 -14.881 1    47.91  ? 230 VAL A N   1 
ATOM   1875 C  CA  . VAL A 1 234 ? -0.291  -26.85  -13.884 1    42.8   ? 230 VAL A CA  1 
ATOM   1876 C  C   . VAL A 1 234 ? 1.018   -26.299 -14.474 1    47.26  ? 230 VAL A C   1 
ATOM   1877 O  O   . VAL A 1 234 ? 1.666   -25.482 -13.83  1    47.52  ? 230 VAL A O   1 
ATOM   1878 C  CB  . VAL A 1 234 ? -0.145  -28.218 -13.207 1    38.89  ? 230 VAL A CB  1 
ATOM   1879 C  CG1 . VAL A 1 234 ? 0.477   -29.273 -14.144 1    38.34  ? 230 VAL A CG1 1 
ATOM   1880 C  CG2 . VAL A 1 234 ? 0.656   -28.083 -11.92  1    36.74  ? 230 VAL A CG2 1 
ATOM   1881 N  N   . THR A 1 235 ? 1.393   -26.711 -15.697 1    48.34  ? 231 THR A N   1 
ATOM   1882 C  CA  . THR A 1 235 ? 2.683   -26.345 -16.285 1    49.16  ? 231 THR A CA  1 
ATOM   1883 C  C   . THR A 1 235 ? 2.764   -24.845 -16.615 1    54.75  ? 231 THR A C   1 
ATOM   1884 O  O   . THR A 1 235 ? 3.848   -24.359 -16.957 1    58.34  ? 231 THR A O   1 
ATOM   1885 C  CB  . THR A 1 235 ? 3.048   -27.194 -17.509 1    48.98  ? 231 THR A CB  1 
ATOM   1886 O  OG1 . THR A 1 235 ? 2.163   -26.861 -18.577 1    54.64  ? 231 THR A OG1 1 
ATOM   1887 C  CG2 . THR A 1 235 ? 3.025   -28.694 -17.273 1    46.06  ? 231 THR A CG2 1 
ATOM   1888 N  N   . SER A 1 236 ? 1.643   -24.12  -16.529 1    50.84  ? 232 SER A N   1 
ATOM   1889 C  CA  . SER A 1 236 ? 1.593   -22.704 -16.868 1    58.28  ? 232 SER A CA  1 
ATOM   1890 C  C   . SER A 1 236 ? 1.66    -21.841 -15.617 1    58.05  ? 232 SER A C   1 
ATOM   1891 O  O   . SER A 1 236 ? 1.867   -20.633 -15.72  1    61.21  ? 232 SER A O   1 
ATOM   1892 C  CB  . SER A 1 236 ? 0.324   -22.342 -17.651 1    58.85  ? 232 SER A CB  1 
ATOM   1893 O  OG  . SER A 1 236 ? 0.57    -22.528 -19.04  1    69.91  ? 232 SER A OG  1 
ATOM   1894 N  N   . MET A 1 237 ? 1.434   -22.463 -14.46  1    55.63  ? 233 MET A N   1 
ATOM   1895 C  CA  . MET A 1 237 ? 1.319   -21.764 -13.187 1    51.54  ? 233 MET A CA  1 
ATOM   1896 C  C   . MET A 1 237 ? 2.573   -20.934 -12.851 1    52.35  ? 233 MET A C   1 
ATOM   1897 O  O   . MET A 1 237 ? 3.699   -21.287 -13.224 1    51.74  ? 233 MET A O   1 
ATOM   1898 C  CB  . MET A 1 237 ? 0.97    -22.777 -12.099 1    51.4   ? 233 MET A CB  1 
ATOM   1899 C  CG  . MET A 1 237 ? -0.522  -22.921 -12.017 1    63.04  ? 233 MET A CG  1 
ATOM   1900 S  SD  . MET A 1 237 ? -1.296  -24.454 -11.488 1    61.75  ? 233 MET A SD  1 
ATOM   1901 C  CE  . MET A 1 237 ? -0.521  -24.408 -9.878  1    85.42  ? 233 MET A CE  1 
ATOM   1902 N  N   . PRO A 1 238 ? 2.421   -19.772 -12.174 1    49.2   ? 234 PRO A N   1 
ATOM   1903 C  CA  . PRO A 1 238 ? 3.536   -18.837 -12.01  1    47.02  ? 234 PRO A CA  1 
ATOM   1904 C  C   . PRO A 1 238 ? 4.836   -19.448 -11.496 1    44.73  ? 234 PRO A C   1 
ATOM   1905 O  O   . PRO A 1 238 ? 5.89    -19.139 -12.02  1    53.74  ? 234 PRO A O   1 
ATOM   1906 C  CB  . PRO A 1 238 ? 2.948   -17.78  -11.041 1    48.45  ? 234 PRO A CB  1 
ATOM   1907 C  CG  . PRO A 1 238 ? 1.447   -17.814 -11.286 1    45.23  ? 234 PRO A CG  1 
ATOM   1908 C  CD  . PRO A 1 238 ? 1.169   -19.29  -11.545 1    47.65  ? 234 PRO A CD  1 
ATOM   1909 N  N   . ASP A 1 239 ? 4.767   -20.37  -10.535 1    41.16  ? 235 ASP A N   1 
ATOM   1910 C  CA  . ASP A 1 239 ? 5.962   -20.924 -9.92   1    45.55  ? 235 ASP A CA  1 
ATOM   1911 C  C   . ASP A 1 239 ? 6.165   -22.392 -10.309 1    45.27  ? 235 ASP A C   1 
ATOM   1912 O  O   . ASP A 1 239 ? 6.995   -23.085 -9.71   1    45.36  ? 235 ASP A O   1 
ATOM   1913 C  CB  . ASP A 1 239 ? 6.037   -20.598 -8.424  1    45.92  ? 235 ASP A CB  1 
ATOM   1914 C  CG  . ASP A 1 239 ? 5.941   -19.111 -8.126  1    46.77  ? 235 ASP A CG  1 
ATOM   1915 O  OD1 . ASP A 1 239 ? 6.487   -18.345 -8.891  1    51.5   ? 235 ASP A OD1 1 
ATOM   1916 O  OD2 . ASP A 1 239 ? 5.236   -18.709 -7.201  1    52.84  ? 235 ASP A OD2 1 
ATOM   1917 N  N   . TYR A 1 240 ? 5.422   -22.859 -11.313 1    43.45  ? 236 TYR A N   1 
ATOM   1918 C  CA  . TYR A 1 240 ? 5.78    -24.103 -11.972 1    47.72  ? 236 TYR A CA  1 
ATOM   1919 C  C   . TYR A 1 240 ? 7.077   -23.879 -12.76  1    47.4   ? 236 TYR A C   1 
ATOM   1920 O  O   . TYR A 1 240 ? 7.236   -22.864 -13.434 1    48.27  ? 236 TYR A O   1 
ATOM   1921 C  CB  . TYR A 1 240 ? 4.681   -24.627 -12.912 1    47.49  ? 236 TYR A CB  1 
ATOM   1922 C  CG  . TYR A 1 240 ? 5.08    -25.97  -13.506 1    51.97  ? 236 TYR A CG  1 
ATOM   1923 C  CD1 . TYR A 1 240 ? 4.857   -27.149 -12.794 1    50.29  ? 236 TYR A CD1 1 
ATOM   1924 C  CD2 . TYR A 1 240 ? 5.739   -26.061 -14.74  1    56.88  ? 236 TYR A CD2 1 
ATOM   1925 C  CE1 . TYR A 1 240 ? 5.228   -28.381 -13.312 1    55.75  ? 236 TYR A CE1 1 
ATOM   1926 C  CE2 . TYR A 1 240 ? 6.127   -27.295 -15.265 1    59.03  ? 236 TYR A CE2 1 
ATOM   1927 C  CZ  . TYR A 1 240 ? 5.892   -28.454 -14.531 1    62.15  ? 236 TYR A CZ  1 
ATOM   1928 O  OH  . TYR A 1 240 ? 6.271   -29.682 -14.995 1    69.05  ? 236 TYR A OH  1 
ATOM   1929 N  N   . LYS A 1 241 ? 7.978   -24.855 -12.684 1    46.96  ? 237 LYS A N   1 
ATOM   1930 C  CA  . LYS A 1 241 ? 9.224   -24.846 -13.436 1    48.41  ? 237 LYS A CA  1 
ATOM   1931 C  C   . LYS A 1 241 ? 9.27    -26.135 -14.258 1    49.4   ? 237 LYS A C   1 
ATOM   1932 O  O   . LYS A 1 241 ? 8.968   -27.209 -13.737 1    50.81  ? 237 LYS A O   1 
ATOM   1933 C  CB  . LYS A 1 241 ? 10.399  -24.77  -12.46  1    49.09  ? 237 LYS A CB  1 
ATOM   1934 C  CG  . LYS A 1 241 ? 10.365  -23.522 -11.574 1    59.04  ? 237 LYS A CG  1 
ATOM   1935 C  CD  . LYS A 1 241 ? 11.653  -23.193 -10.81  1    76.96  ? 237 LYS A CD  1 
ATOM   1936 C  CE  . LYS A 1 241 ? 11.874  -24.147 -9.649  1    85.55  ? 237 LYS A CE  1 
ATOM   1937 N  NZ  . LYS A 1 241 ? 12.227  -23.516 -8.369  1    75.64  ? 237 LYS A NZ  1 
ATOM   1938 N  N   . PRO A 1 242 ? 9.512   -26.073 -15.588 1    48.89  ? 238 PRO A N   1 
ATOM   1939 C  CA  . PRO A 1 242 ? 9.719   -27.291 -16.383 1    49     ? 238 PRO A CA  1 
ATOM   1940 C  C   . PRO A 1 242 ? 10.77   -28.245 -15.814 1    48.94  ? 238 PRO A C   1 
ATOM   1941 O  O   . PRO A 1 242 ? 10.649  -29.456 -15.987 1    50.89  ? 238 PRO A O   1 
ATOM   1942 C  CB  . PRO A 1 242 ? 10.101  -26.83  -17.82  1    48.83  ? 238 PRO A CB  1 
ATOM   1943 C  CG  . PRO A 1 242 ? 10.023  -25.317 -17.779 1    49.01  ? 238 PRO A CG  1 
ATOM   1944 C  CD  . PRO A 1 242 ? 9.539   -24.847 -16.394 1    47.42  ? 238 PRO A CD  1 
ATOM   1945 N  N   . SER A 1 243 ? 11.805  -27.683 -15.176 1    46.31  ? 239 SER A N   1 
ATOM   1946 C  CA  . SER A 1 243 ? 12.924  -28.442 -14.632 1    48.83  ? 239 SER A CA  1 
ATOM   1947 C  C   . SER A 1 243 ? 12.527  -29.315 -13.422 1    45.48  ? 239 SER A C   1 
ATOM   1948 O  O   . SER A 1 243 ? 13.328  -30.153 -12.996 1    43.56  ? 239 SER A O   1 
ATOM   1949 C  CB  . SER A 1 243 ? 14.081  -27.522 -14.258 1    49.62  ? 239 SER A CB  1 
ATOM   1950 O  OG  . SER A 1 243 ? 13.689  -26.687 -13.164 1    51.78  ? 239 SER A OG  1 
ATOM   1951 N  N   . PHE A 1 244 ? 11.31   -29.134 -12.884 1    40.66  ? 240 PHE A N   1 
ATOM   1952 C  CA  . PHE A 1 244 ? 10.827  -29.947 -11.778 1    40.08  ? 240 PHE A CA  1 
ATOM   1953 C  C   . PHE A 1 244 ? 11.089  -31.426 -12.026 1    41.57  ? 240 PHE A C   1 
ATOM   1954 O  O   . PHE A 1 244 ? 10.802  -31.955 -13.105 1    44.33  ? 240 PHE A O   1 
ATOM   1955 C  CB  . PHE A 1 244 ? 9.333   -29.774 -11.533 1    38.48  ? 240 PHE A CB  1 
ATOM   1956 C  CG  . PHE A 1 244 ? 8.941   -28.538 -10.738 1    38.55  ? 240 PHE A CG  1 
ATOM   1957 C  CD1 . PHE A 1 244 ? 9.894   -27.734 -10.108 1    39.3   ? 240 PHE A CD1 1 
ATOM   1958 C  CD2 . PHE A 1 244 ? 7.61    -28.18  -10.65  1    36.53  ? 240 PHE A CD2 1 
ATOM   1959 C  CE1 . PHE A 1 244 ? 9.499   -26.61  -9.406  1    39.28  ? 240 PHE A CE1 1 
ATOM   1960 C  CE2 . PHE A 1 244 ? 7.233   -27.04  -9.976  1    35.64  ? 240 PHE A CE2 1 
ATOM   1961 C  CZ  . PHE A 1 244 ? 8.166   -26.286 -9.33   1    37.34  ? 240 PHE A CZ  1 
ATOM   1962 N  N   . PRO A 1 245 ? 11.644  -32.153 -11.038 1    42.95  ? 241 PRO A N   1 
ATOM   1963 C  CA  . PRO A 1 245 ? 11.838  -33.595 -11.202 1    44.39  ? 241 PRO A CA  1 
ATOM   1964 C  C   . PRO A 1 245 ? 10.451  -34.211 -11.377 1    44.4   ? 241 PRO A C   1 
ATOM   1965 O  O   . PRO A 1 245 ? 9.477   -33.749 -10.765 1    39.31  ? 241 PRO A O   1 
ATOM   1966 C  CB  . PRO A 1 245 ? 12.504  -33.971 -9.872  1    43.74  ? 241 PRO A CB  1 
ATOM   1967 C  CG  . PRO A 1 245 ? 13.211  -32.701 -9.467  1    42.97  ? 241 PRO A CG  1 
ATOM   1968 C  CD  . PRO A 1 245 ? 12.129  -31.653 -9.74   1    42.02  ? 241 PRO A CD  1 
ATOM   1969 N  N   . LYS A 1 246 ? 10.383  -35.252 -12.22  1    46.6   ? 242 LYS A N   1 
ATOM   1970 C  CA  . LYS A 1 246 ? 9.101   -35.87  -12.543 1    49.32  ? 242 LYS A CA  1 
ATOM   1971 C  C   . LYS A 1 246 ? 8.999   -37.202 -11.798 1    49.72  ? 242 LYS A C   1 
ATOM   1972 O  O   . LYS A 1 246 ? 9.363   -38.234 -12.337 1    61.49  ? 242 LYS A O   1 
ATOM   1973 C  CB  . LYS A 1 246 ? 8.94    -36.102 -14.051 1    49.62  ? 242 LYS A CB  1 
ATOM   1974 C  CG  . LYS A 1 246 ? 9.226   -34.932 -14.975 1    62.14  ? 242 LYS A CG  1 
ATOM   1975 C  CD  . LYS A 1 246 ? 8.026   -34.131 -15.468 1    67.6   ? 242 LYS A CD  1 
ATOM   1976 C  CE  . LYS A 1 246 ? 7.967   -34.105 -16.982 1    68.84  ? 242 LYS A CE  1 
ATOM   1977 N  NZ  . LYS A 1 246 ? 9.218   -33.687 -17.607 1    71.26  ? 242 LYS A NZ  1 
ATOM   1978 N  N   . TRP A 1 247 ? 8.521   -37.174 -10.554 1    41.97  ? 243 TRP A N   1 
ATOM   1979 C  CA  . TRP A 1 247 ? 8.426   -38.375 -9.752  1    39.7   ? 243 TRP A CA  1 
ATOM   1980 C  C   . TRP A 1 247 ? 7.143   -39.114 -10.113 1    38.93  ? 243 TRP A C   1 
ATOM   1981 O  O   . TRP A 1 247 ? 6.101   -38.484 -10.305 1    38.92  ? 243 TRP A O   1 
ATOM   1982 C  CB  . TRP A 1 247 ? 8.422   -38.028 -8.251  1    37.91  ? 243 TRP A CB  1 
ATOM   1983 C  CG  . TRP A 1 247 ? 9.77    -37.642 -7.71   1    38.67  ? 243 TRP A CG  1 
ATOM   1984 C  CD1 . TRP A 1 247 ? 10.829  -38.473 -7.427  1    39.6   ? 243 TRP A CD1 1 
ATOM   1985 C  CD2 . TRP A 1 247 ? 10.198  -36.308 -7.368  1    37.61  ? 243 TRP A CD2 1 
ATOM   1986 N  NE1 . TRP A 1 247 ? 11.897  -37.744 -6.96   1    39.69  ? 243 TRP A NE1 1 
ATOM   1987 C  CE2 . TRP A 1 247 ? 11.537  -36.414 -6.909  1    40.34  ? 243 TRP A CE2 1 
ATOM   1988 C  CE3 . TRP A 1 247 ? 9.603   -35.048 -7.436  1    36.42  ? 243 TRP A CE3 1 
ATOM   1989 C  CZ2 . TRP A 1 247 ? 12.262  -35.292 -6.501  1    39.66  ? 243 TRP A CZ2 1 
ATOM   1990 C  CZ3 . TRP A 1 247 ? 10.32   -33.946 -7.01   1    36.7   ? 243 TRP A CZ3 1 
ATOM   1991 C  CH2 . TRP A 1 247 ? 11.626  -34.069 -6.54   1    37.17  ? 243 TRP A CH2 1 
ATOM   1992 N  N   . ALA A 1 248 ? 7.225   -40.446 -10.106 1    40.81  ? 244 ALA A N   1 
ATOM   1993 C  CA  . ALA A 1 248 ? 6.081   -41.324 -10.269 1    44.31  ? 244 ALA A CA  1 
ATOM   1994 C  C   . ALA A 1 248 ? 5.166   -41.237 -9.04   1    46.96  ? 244 ALA A C   1 
ATOM   1995 O  O   . ALA A 1 248 ? 5.636   -41.059 -7.908  1    48.66  ? 244 ALA A O   1 
ATOM   1996 C  CB  . ALA A 1 248 ? 6.556   -42.74  -10.521 1    42.17  ? 244 ALA A CB  1 
ATOM   1997 N  N   . ARG A 1 249 ? 3.853   -41.33  -9.287  1    45     ? 245 ARG A N   1 
ATOM   1998 C  CA  . ARG A 1 249 ? 2.878   -41.444 -8.221  1    47.21  ? 245 ARG A CA  1 
ATOM   1999 C  C   . ARG A 1 249 ? 3.038   -42.807 -7.563  1    51.05  ? 245 ARG A C   1 
ATOM   2000 O  O   . ARG A 1 249 ? 3.058   -43.827 -8.24   1    50.69  ? 245 ARG A O   1 
ATOM   2001 C  CB  . ARG A 1 249 ? 1.479   -41.299 -8.818  1    46.96  ? 245 ARG A CB  1 
ATOM   2002 C  CG  . ARG A 1 249 ? 0.373   -41.544 -7.801  1    48.6   ? 245 ARG A CG  1 
ATOM   2003 C  CD  . ARG A 1 249 ? -0.987  -41.089 -8.303  1    46.14  ? 245 ARG A CD  1 
ATOM   2004 N  NE  . ARG A 1 249 ? -1.906  -41.228 -7.169  1    55.01  ? 245 ARG A NE  1 
ATOM   2005 C  CZ  . ARG A 1 249 ? -2.399  -40.22  -6.444  1    52.7   ? 245 ARG A CZ  1 
ATOM   2006 N  NH1 . ARG A 1 249 ? -1.797  -39.026 -6.48   1    43.92  ? 245 ARG A NH1 1 
ATOM   2007 N  NH2 . ARG A 1 249 ? -3.447  -40.455 -5.642  1    48.06  ? 245 ARG A NH2 1 
ATOM   2008 N  N   . GLN A 1 250 ? 3.231   -42.82  -6.246  1    58.71  ? 246 GLN A N   1 
ATOM   2009 C  CA  . GLN A 1 250 ? 3.316   -44.1   -5.568  1    64.25  ? 246 GLN A CA  1 
ATOM   2010 C  C   . GLN A 1 250 ? 1.881   -44.524 -5.25   1    68.77  ? 246 GLN A C   1 
ATOM   2011 O  O   . GLN A 1 250 ? 1.019   -43.663 -4.987  1    60.88  ? 246 GLN A O   1 
ATOM   2012 C  CB  . GLN A 1 250 ? 4.324   -44.053 -4.413  1    64.57  ? 246 GLN A CB  1 
ATOM   2013 C  CG  . GLN A 1 250 ? 3.75    -43.564 -3.09   1    65.08  ? 246 GLN A CG  1 
ATOM   2014 C  CD  . GLN A 1 250 ? 4.829   -43.338 -2.05   1    73.07  ? 246 GLN A CD  1 
ATOM   2015 O  OE1 . GLN A 1 250 ? 4.938   -42.233 -1.509  1    68.95  ? 246 GLN A OE1 1 
ATOM   2016 N  NE2 . GLN A 1 250 ? 5.645   -44.357 -1.769  1    81.12  ? 246 GLN A NE2 1 
ATOM   2017 N  N   . ASP A 1 251 ? 1.662   -45.848 -5.33   1    67.61  ? 247 ASP A N   1 
ATOM   2018 C  CA  . ASP A 1 251 ? 0.416   -46.489 -4.961  1    66.66  ? 247 ASP A CA  1 
ATOM   2019 C  C   . ASP A 1 251 ? 0.018   -46.001 -3.568  1    62.63  ? 247 ASP A C   1 
ATOM   2020 O  O   . ASP A 1 251 ? 0.828   -46.029 -2.641  1    61.49  ? 247 ASP A O   1 
ATOM   2021 C  CB  . ASP A 1 251 ? 0.493   -47.988 -5.233  1    78.68  ? 247 ASP A CB  1 
ATOM   2022 C  CG  . ASP A 1 251 ? -0.504  -48.871 -4.489  1    95.44  ? 247 ASP A CG  1 
ATOM   2023 O  OD1 . ASP A 1 251 ? -1.681  -48.434 -4.327  1    95.94  ? 247 ASP A OD1 1 
ATOM   2024 O  OD2 . ASP A 1 251 ? -0.105  -50.011 -4.102  1    103.37 ? 247 ASP A OD2 1 
ATOM   2025 N  N   . PHE A 1 252 ? -1.236  -45.549 -3.442  1    52.97  ? 248 PHE A N   1 
ATOM   2026 C  CA  . PHE A 1 252 ? -1.725  -44.806 -2.294  1    50.32  ? 248 PHE A CA  1 
ATOM   2027 C  C   . PHE A 1 252 ? -1.797  -45.638 -1.008  1    48.6   ? 248 PHE A C   1 
ATOM   2028 O  O   . PHE A 1 252 ? -1.902  -45.101 0.096   1    53.27  ? 248 PHE A O   1 
ATOM   2029 C  CB  . PHE A 1 252 ? -3.116  -44.288 -2.685  1    58.28  ? 248 PHE A CB  1 
ATOM   2030 C  CG  . PHE A 1 252 ? -3.357  -42.928 -2.052  1    54.05  ? 248 PHE A CG  1 
ATOM   2031 C  CD1 . PHE A 1 252 ? -2.896  -41.781 -2.703  1    50.57  ? 248 PHE A CD1 1 
ATOM   2032 C  CD2 . PHE A 1 252 ? -3.931  -42.804 -0.8    1    47.3   ? 248 PHE A CD2 1 
ATOM   2033 C  CE1 . PHE A 1 252 ? -3.053  -40.53  -2.151  1    41.58  ? 248 PHE A CE1 1 
ATOM   2034 C  CE2 . PHE A 1 252 ? -4.066  -41.533 -0.249  1    47.58  ? 248 PHE A CE2 1 
ATOM   2035 C  CZ  . PHE A 1 252 ? -3.625  -40.419 -0.923  1    42.39  ? 248 PHE A CZ  1 
ATOM   2036 N  N   . SER A 1 253 ? -1.819  -46.96  -1.143  1    49.68  ? 249 SER A N   1 
ATOM   2037 C  CA  . SER A 1 253 ? -1.791  -47.863 -0.002  1    52.73  ? 249 SER A CA  1 
ATOM   2038 C  C   . SER A 1 253 ? -0.445  -47.781 0.732   1    57.22  ? 249 SER A C   1 
ATOM   2039 O  O   . SER A 1 253 ? -0.326  -48.223 1.887   1    56.14  ? 249 SER A O   1 
ATOM   2040 C  CB  . SER A 1 253 ? -2.084  -49.282 -0.441  1    50.45  ? 249 SER A CB  1 
ATOM   2041 O  OG  . SER A 1 253 ? -1.1    -49.723 -1.37   1    57.25  ? 249 SER A OG  1 
ATOM   2042 N  N   . LYS A 1 254 ? 0.567   -47.23  0.045   1    56.07  ? 250 LYS A N   1 
ATOM   2043 C  CA  . LYS A 1 254 ? 1.911   -47.125 0.594   1    56.44  ? 250 LYS A CA  1 
ATOM   2044 C  C   . LYS A 1 254 ? 2.065   -45.808 1.35    1    49.91  ? 250 LYS A C   1 
ATOM   2045 O  O   . LYS A 1 254 ? 2.945   -45.691 2.176   1    52.47  ? 250 LYS A O   1 
ATOM   2046 C  CB  . LYS A 1 254 ? 2.963   -47.285 -0.504  1    62.48  ? 250 LYS A CB  1 
ATOM   2047 C  CG  . LYS A 1 254 ? 2.718   -48.498 -1.397  1    80.84  ? 250 LYS A CG  1 
ATOM   2048 C  CD  . LYS A 1 254 ? 3.808   -48.714 -2.451  1    115.53 ? 250 LYS A CD  1 
ATOM   2049 C  CE  . LYS A 1 254 ? 3.451   -49.5   -3.684  1    126.87 ? 250 LYS A CE  1 
ATOM   2050 N  NZ  . LYS A 1 254 ? 3.969   -48.86  -4.899  1    113.93 ? 250 LYS A NZ  1 
ATOM   2051 N  N   . VAL A 1 255 ? 1.187   -44.836 1.104   1    46.41  ? 251 VAL A N   1 
ATOM   2052 C  CA  . VAL A 1 255 ? 1.299   -43.513 1.693   1    44.57  ? 251 VAL A CA  1 
ATOM   2053 C  C   . VAL A 1 255 ? 0.855   -43.535 3.157   1    48.85  ? 251 VAL A C   1 
ATOM   2054 O  O   . VAL A 1 255 ? 1.443   -42.849 3.993   1    49.84  ? 251 VAL A O   1 
ATOM   2055 C  CB  . VAL A 1 255 ? 0.47    -42.497 0.907   1    41.72  ? 251 VAL A CB  1 
ATOM   2056 C  CG1 . VAL A 1 255 ? 0.533   -41.113 1.547   1    40.77  ? 251 VAL A CG1 1 
ATOM   2057 C  CG2 . VAL A 1 255 ? 0.929   -42.465 -0.544  1    42.38  ? 251 VAL A CG2 1 
ATOM   2058 N  N   . VAL A 1 256 ? -0.196  -44.309 3.454   1    48.26  ? 252 VAL A N   1 
ATOM   2059 C  CA  . VAL A 1 256 ? -0.686  -44.502 4.801   1    42.91  ? 252 VAL A CA  1 
ATOM   2060 C  C   . VAL A 1 256 ? -1.11   -45.957 4.918   1    45.36  ? 252 VAL A C   1 
ATOM   2061 O  O   . VAL A 1 256 ? -2.304  -46.264 4.996   1    46.54  ? 252 VAL A O   1 
ATOM   2062 C  CB  . VAL A 1 256 ? -1.828  -43.552 5.172   1    42.87  ? 252 VAL A CB  1 
ATOM   2063 C  CG1 . VAL A 1 256 ? -2.204  -43.694 6.647   1    48.12  ? 252 VAL A CG1 1 
ATOM   2064 C  CG2 . VAL A 1 256 ? -1.446  -42.107 4.884   1    41.14  ? 252 VAL A CG2 1 
ATOM   2065 N  N   . PRO A 1 257 ? -0.121  -46.862 5.027   1    43.5   ? 253 PRO A N   1 
ATOM   2066 C  CA  . PRO A 1 257 ? -0.362  -48.302 5.071   1    46.23  ? 253 PRO A CA  1 
ATOM   2067 C  C   . PRO A 1 257 ? -1.487  -48.826 5.952   1    47.99  ? 253 PRO A C   1 
ATOM   2068 O  O   . PRO A 1 257 ? -2.177  -49.736 5.529   1    53.53  ? 253 PRO A O   1 
ATOM   2069 C  CB  . PRO A 1 257 ? 1.017   -48.887 5.51    1    46.71  ? 253 PRO A CB  1 
ATOM   2070 C  CG  . PRO A 1 257 ? 2.022   -47.853 5.052   1    44.62  ? 253 PRO A CG  1 
ATOM   2071 C  CD  . PRO A 1 257 ? 1.302   -46.515 5.2     1    43.86  ? 253 PRO A CD  1 
ATOM   2072 N  N   . PRO A 1 258 ? -1.681  -48.374 7.21    1    47.78  ? 254 PRO A N   1 
ATOM   2073 C  CA  . PRO A 1 258 ? -2.706  -48.968 8.067   1    49.19  ? 254 PRO A CA  1 
ATOM   2074 C  C   . PRO A 1 258 ? -4.126  -48.612 7.632   1    50.53  ? 254 PRO A C   1 
ATOM   2075 O  O   . PRO A 1 258 ? -5.063  -49.178 8.179   1    59.59  ? 254 PRO A O   1 
ATOM   2076 C  CB  . PRO A 1 258 ? -2.47   -48.403 9.475   1    47.77  ? 254 PRO A CB  1 
ATOM   2077 C  CG  . PRO A 1 258 ? -1.285  -47.464 9.344   1    47.92  ? 254 PRO A CG  1 
ATOM   2078 C  CD  . PRO A 1 258 ? -0.967  -47.276 7.876   1    46.44  ? 254 PRO A CD  1 
ATOM   2079 N  N   . LEU A 1 259 ? -4.292  -47.656 6.704   1    46.11  ? 255 LEU A N   1 
ATOM   2080 C  CA  . LEU A 1 259 ? -5.617  -47.15  6.36    1    44.57  ? 255 LEU A CA  1 
ATOM   2081 C  C   . LEU A 1 259 ? -6.32   -48.163 5.455   1    49.01  ? 255 LEU A C   1 
ATOM   2082 O  O   . LEU A 1 259 ? -5.676  -48.741 4.568   1    48.49  ? 255 LEU A O   1 
ATOM   2083 C  CB  . LEU A 1 259 ? -5.409  -45.831 5.629   1    41.13  ? 255 LEU A CB  1 
ATOM   2084 C  CG  . LEU A 1 259 ? -6.533  -44.807 5.72    1    40.68  ? 255 LEU A CG  1 
ATOM   2085 C  CD1 . LEU A 1 259 ? -6.993  -44.517 7.153   1    40.17  ? 255 LEU A CD1 1 
ATOM   2086 C  CD2 . LEU A 1 259 ? -6.055  -43.54  5.065   1    36.94  ? 255 LEU A CD2 1 
ATOM   2087 N  N   . ASP A 1 260 ? -7.623  -48.385 5.716   1    49.01  ? 256 ASP A N   1 
ATOM   2088 C  CA  . ASP A 1 260 ? -8.502  -49.302 4.978   1    51.86  ? 256 ASP A CA  1 
ATOM   2089 C  C   . ASP A 1 260 ? -8.848  -48.708 3.6     1    49.14  ? 256 ASP A C   1 
ATOM   2090 O  O   . ASP A 1 260 ? -8.579  -47.544 3.328   1    45.05  ? 256 ASP A O   1 
ATOM   2091 C  CB  . ASP A 1 260 ? -9.782  -49.567 5.766   1    61.26  ? 256 ASP A CB  1 
ATOM   2092 C  CG  . ASP A 1 260 ? -10.653 -48.329 6.066   1    67.08  ? 256 ASP A CG  1 
ATOM   2093 O  OD1 . ASP A 1 260 ? -11.043 -47.622 5.107   1    67     ? 256 ASP A OD1 1 
ATOM   2094 O  OD2 . ASP A 1 260 ? -10.934 -48.023 7.252   1    64.44  ? 256 ASP A OD2 1 
ATOM   2095 N  N   . GLU A 1 261 ? -9.522  -49.484 2.744   1    50.07  ? 257 GLU A N   1 
ATOM   2096 C  CA  . GLU A 1 261 ? -9.878  -49.047 1.402   1    50.9   ? 257 GLU A CA  1 
ATOM   2097 C  C   . GLU A 1 261 ? -10.717 -47.762 1.347   1    49.32  ? 257 GLU A C   1 
ATOM   2098 O  O   . GLU A 1 261 ? -10.469 -46.932 0.478   1    48.71  ? 257 GLU A O   1 
ATOM   2099 C  CB  . GLU A 1 261 ? -10.69  -50.157 0.766   1    57.92  ? 257 GLU A CB  1 
ATOM   2100 C  CG  . GLU A 1 261 ? -10.839 -50.03  -0.752  1    66.36  ? 257 GLU A CG  1 
ATOM   2101 C  CD  . GLU A 1 261 ? -11.778 -51.146 -1.192  1    75.84  ? 257 GLU A CD  1 
ATOM   2102 O  OE1 . GLU A 1 261 ? -11.242 -52.066 -1.848  1    77.02  ? 257 GLU A OE1 1 
ATOM   2103 O  OE2 . GLU A 1 261 ? -12.997 -51.136 -0.827  1    76.85  ? 257 GLU A OE2 1 
ATOM   2104 N  N   . ASP A 1 262 ? -11.691 -47.588 2.26    1    47.71  ? 258 ASP A N   1 
ATOM   2105 C  CA  . ASP A 1 262 ? -12.567 -46.419 2.306   1    43.63  ? 258 ASP A CA  1 
ATOM   2106 C  C   . ASP A 1 262 ? -11.764 -45.186 2.701   1    42.66  ? 258 ASP A C   1 
ATOM   2107 O  O   . ASP A 1 262 ? -11.839 -44.148 2.039   1    42.24  ? 258 ASP A O   1 
ATOM   2108 C  CB  . ASP A 1 262 ? -13.758 -46.629 3.233   1    44.98  ? 258 ASP A CB  1 
ATOM   2109 C  CG  . ASP A 1 262 ? -14.854 -47.567 2.732   1    50.85  ? 258 ASP A CG  1 
ATOM   2110 O  OD1 . ASP A 1 262 ? -14.939 -47.761 1.505   1    52.95  ? 258 ASP A OD1 1 
ATOM   2111 O  OD2 . ASP A 1 262 ? -15.597 -48.158 3.574   1    55.89  ? 258 ASP A OD2 1 
ATOM   2112 N  N   . GLY A 1 263 ? -10.996 -45.306 3.801   1    40.87  ? 259 GLY A N   1 
ATOM   2113 C  CA  . GLY A 1 263 ? -10.089 -44.256 4.225   1    36.77  ? 259 GLY A CA  1 
ATOM   2114 C  C   . GLY A 1 263 ? -9.162  -43.824 3.089   1    36.34  ? 259 GLY A C   1 
ATOM   2115 O  O   . GLY A 1 263 ? -9.016  -42.634 2.824   1    35.37  ? 259 GLY A O   1 
ATOM   2116 N  N   . ARG A 1 264 ? -8.588  -44.775 2.374   1    36.79  ? 260 ARG A N   1 
ATOM   2117 C  CA  . ARG A 1 264 ? -7.641  -44.409 1.298   1    39.89  ? 260 ARG A CA  1 
ATOM   2118 C  C   . ARG A 1 264 ? -8.408  -43.68  0.19    1    39.89  ? 260 ARG A C   1 
ATOM   2119 O  O   . ARG A 1 264 ? -7.874  -42.708 -0.35   1    39.22  ? 260 ARG A O   1 
ATOM   2120 C  CB  . ARG A 1 264 ? -6.894  -45.662 0.835   1    42.78  ? 260 ARG A CB  1 
ATOM   2121 C  CG  . ARG A 1 264 ? -5.853  -46.067 1.867   1    49.1   ? 260 ARG A CG  1 
ATOM   2122 C  CD  . ARG A 1 264 ? -4.973  -47.208 1.405   1    50.64  ? 260 ARG A CD  1 
ATOM   2123 N  NE  . ARG A 1 264 ? -5.596  -48.013 0.35    1    49.85  ? 260 ARG A NE  1 
ATOM   2124 C  CZ  . ARG A 1 264 ? -6.156  -49.193 0.552   1    52.7   ? 260 ARG A CZ  1 
ATOM   2125 N  NH1 . ARG A 1 264 ? -6.044  -49.784 1.725   1    50.31  ? 260 ARG A NH1 1 
ATOM   2126 N  NH2 . ARG A 1 264 ? -6.828  -49.775 -0.421  1    54.43  ? 260 ARG A NH2 1 
ATOM   2127 N  N   . SER A 1 265 ? -9.62   -44.133 -0.111  1    40.76  ? 261 SER A N   1 
ATOM   2128 C  CA  . SER A 1 265 ? -10.426 -43.466 -1.11   1    39.58  ? 261 SER A CA  1 
ATOM   2129 C  C   . SER A 1 265 ? -10.627 -42.002 -0.714  1    40.24  ? 261 SER A C   1 
ATOM   2130 O  O   . SER A 1 265 ? -10.41  -41.095 -1.53   1    39.63  ? 261 SER A O   1 
ATOM   2131 C  CB  . SER A 1 265 ? -11.744 -44.176 -1.282  1    39.98  ? 261 SER A CB  1 
ATOM   2132 O  OG  . SER A 1 265 ? -12.686 -43.338 -1.946  1    41.97  ? 261 SER A OG  1 
ATOM   2133 N  N   . LEU A 1 266 ? -11.036 -41.787 0.551   1    37.94  ? 262 LEU A N   1 
ATOM   2134 C  CA  . LEU A 1 266 ? -11.391 -40.461 0.999   1    36.77  ? 262 LEU A CA  1 
ATOM   2135 C  C   . LEU A 1 266 ? -10.152 -39.576 0.975   1    36.9   ? 262 LEU A C   1 
ATOM   2136 O  O   . LEU A 1 266 ? -10.209 -38.433 0.465   1    38.59  ? 262 LEU A O   1 
ATOM   2137 C  CB  . LEU A 1 266 ? -12.06  -40.508 2.378   1    36.56  ? 262 LEU A CB  1 
ATOM   2138 C  CG  . LEU A 1 266 ? -12.226 -39.155 3.082   1    35.1   ? 262 LEU A CG  1 
ATOM   2139 C  CD1 . LEU A 1 266 ? -12.966 -38.144 2.166   1    32.69  ? 262 LEU A CD1 1 
ATOM   2140 C  CD2 . LEU A 1 266 ? -12.942 -39.333 4.393   1    35.77  ? 262 LEU A CD2 1 
ATOM   2141 N  N   . LEU A 1 267 ? -9.045  -40.119 1.514   1    34.85  ? 263 LEU A N   1 
ATOM   2142 C  CA  . LEU A 1 267 ? -7.803  -39.372 1.598   1    34.58  ? 263 LEU A CA  1 
ATOM   2143 C  C   . LEU A 1 267 ? -7.347  -38.953 0.202   1    35.41  ? 263 LEU A C   1 
ATOM   2144 O  O   . LEU A 1 267 ? -6.923  -37.81  0.021   1    37.54  ? 263 LEU A O   1 
ATOM   2145 C  CB  . LEU A 1 267 ? -6.732  -40.188 2.31    1    41.18  ? 263 LEU A CB  1 
ATOM   2146 C  CG  . LEU A 1 267 ? -5.388  -39.482 2.518   1    38.09  ? 263 LEU A CG  1 
ATOM   2147 C  CD1 . LEU A 1 267 ? -5.578  -38.321 3.453   1    36.82  ? 263 LEU A CD1 1 
ATOM   2148 C  CD2 . LEU A 1 267 ? -4.388  -40.461 3.085   1    38.31  ? 263 LEU A CD2 1 
ATOM   2149 N  N   . SER A 1 268 ? -7.439  -39.869 -0.766  1    34.01  ? 264 SER A N   1 
ATOM   2150 C  CA  . SER A 1 268 ? -7.004  -39.578 -2.123  1    37.69  ? 264 SER A CA  1 
ATOM   2151 C  C   . SER A 1 268 ? -7.794  -38.404 -2.697  1    36.27  ? 264 SER A C   1 
ATOM   2152 O  O   . SER A 1 268 ? -7.269  -37.58  -3.452  1    37     ? 264 SER A O   1 
ATOM   2153 C  CB  . SER A 1 268 ? -7.049  -40.789 -3.038  1    41.45  ? 264 SER A CB  1 
ATOM   2154 O  OG  . SER A 1 268 ? -8.375  -41.283 -3.187  1    46.42  ? 264 SER A OG  1 
ATOM   2155 N  N   . GLN A 1 269 ? -9.047  -38.301 -2.29   1    34.98  ? 265 GLN A N   1 
ATOM   2156 C  CA  . GLN A 1 269 ? -9.895  -37.288 -2.885  1    37.99  ? 265 GLN A CA  1 
ATOM   2157 C  C   . GLN A 1 269 ? -9.668  -35.953 -2.195  1    37.3   ? 265 GLN A C   1 
ATOM   2158 O  O   . GLN A 1 269 ? -9.932  -34.912 -2.779  1    39.5   ? 265 GLN A O   1 
ATOM   2159 C  CB  . GLN A 1 269 ? -11.354 -37.738 -2.857  1    41.12  ? 265 GLN A CB  1 
ATOM   2160 C  CG  . GLN A 1 269 ? -11.606 -38.947 -3.75   1    40.98  ? 265 GLN A CG  1 
ATOM   2161 C  CD  . GLN A 1 269 ? -13.039 -39.408 -3.618  1    47.84  ? 265 GLN A CD  1 
ATOM   2162 O  OE1 . GLN A 1 269 ? -13.337 -40.494 -3.104  1    50.3   ? 265 GLN A OE1 1 
ATOM   2163 N  NE2 . GLN A 1 269 ? -13.954 -38.542 -4.016  1    51.18  ? 265 GLN A NE2 1 
ATOM   2164 N  N   . MET A 1 270 ? -9.16   -35.977 -0.956  1    38.15  ? 266 MET A N   1 
ATOM   2165 C  CA  . MET A 1 270 ? -8.826  -34.74  -0.271  1    35.3   ? 266 MET A CA  1 
ATOM   2166 C  C   . MET A 1 270 ? -7.512  -34.14  -0.776  1    42.43  ? 266 MET A C   1 
ATOM   2167 O  O   . MET A 1 270 ? -7.347  -32.906 -0.758  1    45.78  ? 266 MET A O   1 
ATOM   2168 C  CB  . MET A 1 270 ? -8.801  -34.961 1.237   1    33.11  ? 266 MET A CB  1 
ATOM   2169 C  CG  . MET A 1 270 ? -10.173 -35.334 1.752   1    32.1   ? 266 MET A CG  1 
ATOM   2170 S  SD  . MET A 1 270 ? -10.206 -35.645 3.53    1    38.24  ? 266 MET A SD  1 
ATOM   2171 C  CE  . MET A 1 270 ? -10.196 -33.998 4.245   1    26.15  ? 266 MET A CE  1 
ATOM   2172 N  N   . LEU A 1 271 ? -6.615  -35.006 -1.281  1    39.18  ? 267 LEU A N   1 
ATOM   2173 C  CA  . LEU A 1 271 ? -5.284  -34.622 -1.713  1    37.39  ? 267 LEU A CA  1 
ATOM   2174 C  C   . LEU A 1 271 ? -5.178  -34.7   -3.233  1    43.94  ? 267 LEU A C   1 
ATOM   2175 O  O   . LEU A 1 271 ? -4.09   -34.862 -3.791  1    40.59  ? 267 LEU A O   1 
ATOM   2176 C  CB  . LEU A 1 271 ? -4.316  -35.6   -1.058  1    34.94  ? 267 LEU A CB  1 
ATOM   2177 C  CG  . LEU A 1 271 ? -4.269  -35.605 0.469   1    35.51  ? 267 LEU A CG  1 
ATOM   2178 C  CD1 . LEU A 1 271 ? -3.284  -36.66  0.955   1    37.35  ? 267 LEU A CD1 1 
ATOM   2179 C  CD2 . LEU A 1 271 ? -3.876  -34.231 0.987   1    33.65  ? 267 LEU A CD2 1 
ATOM   2180 N  N   . HIS A 1 272 ? -6.315  -34.593 -3.919  1    39.41  ? 268 HIS A N   1 
ATOM   2181 C  CA  . HIS A 1 272 ? -6.284  -34.517 -5.368  1    41.93  ? 268 HIS A CA  1 
ATOM   2182 C  C   . HIS A 1 272 ? -5.591  -33.213 -5.786  1    43.48  ? 268 HIS A C   1 
ATOM   2183 O  O   . HIS A 1 272 ? -5.864  -32.135 -5.234  1    36.97  ? 268 HIS A O   1 
ATOM   2184 C  CB  . HIS A 1 272 ? -7.743  -34.578 -5.829  1    50.61  ? 268 HIS A CB  1 
ATOM   2185 C  CG  . HIS A 1 272 ? -7.927  -35.19  -7.145  1    54.08  ? 268 HIS A CG  1 
ATOM   2186 N  ND1 . HIS A 1 272 ? -7.588  -34.478 -8.282  1    65.01  ? 268 HIS A ND1 1 
ATOM   2187 C  CD2 . HIS A 1 272 ? -8.349  -36.409 -7.52   1    55.58  ? 268 HIS A CD2 1 
ATOM   2188 C  CE1 . HIS A 1 272 ? -7.844  -35.222 -9.347  1    61.39  ? 268 HIS A CE1 1 
ATOM   2189 N  NE2 . HIS A 1 272 ? -8.3    -36.396 -8.906  1    66.19  ? 268 HIS A NE2 1 
ATOM   2190 N  N   . TYR A 1 273 ? -4.686  -33.3   -6.768  1    46.43  ? 269 TYR A N   1 
ATOM   2191 C  CA  . TYR A 1 273 ? -3.918  -32.124 -7.173  1    42.42  ? 269 TYR A CA  1 
ATOM   2192 C  C   . TYR A 1 273 ? -4.862  -31.006 -7.624  1    41.78  ? 269 TYR A C   1 
ATOM   2193 O  O   . TYR A 1 273 ? -4.801  -29.878 -7.111  1    40.1   ? 269 TYR A O   1 
ATOM   2194 C  CB  . TYR A 1 273 ? -2.908  -32.424 -8.287  1    36.42  ? 269 TYR A CB  1 
ATOM   2195 C  CG  . TYR A 1 273 ? -1.581  -32.92  -7.757  1    38.75  ? 269 TYR A CG  1 
ATOM   2196 C  CD1 . TYR A 1 273 ? -0.767  -32.064 -7.019  1    37.92  ? 269 TYR A CD1 1 
ATOM   2197 C  CD2 . TYR A 1 273 ? -1.143  -34.222 -7.982  1    38.13  ? 269 TYR A CD2 1 
ATOM   2198 C  CE1 . TYR A 1 273 ? 0.453   -32.482 -6.514  1    39.3   ? 269 TYR A CE1 1 
ATOM   2199 C  CE2 . TYR A 1 273 ? 0.064   -34.661 -7.449  1    37.52  ? 269 TYR A CE2 1 
ATOM   2200 C  CZ  . TYR A 1 273 ? 0.875   -33.785 -6.737  1    38.38  ? 269 TYR A CZ  1 
ATOM   2201 O  OH  . TYR A 1 273 ? 2.078   -34.172 -6.228  1    37.68  ? 269 TYR A OH  1 
ATOM   2202 N  N   . ASP A 1 274 ? -5.737  -31.357 -8.581  1    35.79  ? 270 ASP A N   1 
ATOM   2203 C  CA  . ASP A 1 274 ? -6.548  -30.373 -9.269  1    37.69  ? 270 ASP A CA  1 
ATOM   2204 C  C   . ASP A 1 274 ? -7.593  -29.841 -8.291  1    38.37  ? 270 ASP A C   1 
ATOM   2205 O  O   . ASP A 1 274 ? -8.438  -30.621 -7.885  1    36.54  ? 270 ASP A O   1 
ATOM   2206 C  CB  . ASP A 1 274 ? -7.185  -31.015 -10.491 1    38.28  ? 270 ASP A CB  1 
ATOM   2207 C  CG  . ASP A 1 274 ? -7.986  -30.062 -11.341 1    42.83  ? 270 ASP A CG  1 
ATOM   2208 O  OD1 . ASP A 1 274 ? -8.241  -28.919 -10.857 1    41.51  ? 270 ASP A OD1 1 
ATOM   2209 O  OD2 . ASP A 1 274 ? -8.347  -30.482 -12.462 1    47.94  ? 270 ASP A OD2 1 
ATOM   2210 N  N   . PRO A 1 275 ? -7.577  -28.547 -7.856  1    40.43  ? 271 PRO A N   1 
ATOM   2211 C  CA  . PRO A 1 275 ? -8.513  -28.063 -6.835  1    38.24  ? 271 PRO A CA  1 
ATOM   2212 C  C   . PRO A 1 275 ? -9.968  -28.228 -7.262  1    40.87  ? 271 PRO A C   1 
ATOM   2213 O  O   . PRO A 1 275 ? -10.865 -28.329 -6.418  1    41.82  ? 271 PRO A O   1 
ATOM   2214 C  CB  . PRO A 1 275 ? -8.141  -26.562 -6.669  1    37.56  ? 271 PRO A CB  1 
ATOM   2215 C  CG  . PRO A 1 275 ? -6.721  -26.475 -7.143  1    35.03  ? 271 PRO A CG  1 
ATOM   2216 C  CD  . PRO A 1 275 ? -6.68   -27.469 -8.311  1    36.98  ? 271 PRO A CD  1 
ATOM   2217 N  N   . ASN A 1 276 ? -10.188 -28.289 -8.585  1    39.83  ? 272 ASN A N   1 
ATOM   2218 C  CA  . ASN A 1 276 ? -11.536 -28.479 -9.099  1    43.98  ? 272 ASN A CA  1 
ATOM   2219 C  C   . ASN A 1 276 ? -12.043 -29.897 -8.836  1    41.43  ? 272 ASN A C   1 
ATOM   2220 O  O   . ASN A 1 276 ? -13.238 -30.056 -8.787  1    39.13  ? 272 ASN A O   1 
ATOM   2221 C  CB  . ASN A 1 276 ? -11.639 -28.257 -10.604 1    45.72  ? 272 ASN A CB  1 
ATOM   2222 C  CG  . ASN A 1 276 ? -11.321 -26.845 -11.022 1    50.09  ? 272 ASN A CG  1 
ATOM   2223 O  OD1 . ASN A 1 276 ? -11.551 -25.892 -10.266 1    48.13  ? 272 ASN A OD1 1 
ATOM   2224 N  ND2 . ASN A 1 276 ? -10.802 -26.701 -12.234 1    53.38  ? 272 ASN A ND2 1 
ATOM   2225 N  N   . LYS A 1 277 ? -11.165 -30.905 -8.718  1    41.44  ? 273 LYS A N   1 
ATOM   2226 C  CA  . LYS A 1 277 ? -11.559 -32.303 -8.574  1    45.76  ? 273 LYS A CA  1 
ATOM   2227 C  C   . LYS A 1 277 ? -11.473 -32.729 -7.111  1    39.88  ? 273 LYS A C   1 
ATOM   2228 O  O   . LYS A 1 277 ? -11.925 -33.806 -6.737  1    38.91  ? 273 LYS A O   1 
ATOM   2229 C  CB  . LYS A 1 277 ? -10.677 -33.267 -9.387  1    49.51  ? 273 LYS A CB  1 
ATOM   2230 C  CG  . LYS A 1 277 ? -10.597 -33.006 -10.876 1    62.23  ? 273 LYS A CG  1 
ATOM   2231 C  CD  . LYS A 1 277 ? -11.952 -32.803 -11.557 1    72.24  ? 273 LYS A CD  1 
ATOM   2232 C  CE  . LYS A 1 277 ? -11.846 -32.701 -13.069 1    93.41  ? 273 LYS A CE  1 
ATOM   2233 N  NZ  . LYS A 1 277 ? -13.164 -32.6   -13.708 1    95.77  ? 273 LYS A NZ  1 
ATOM   2234 N  N   . ARG A 1 278 ? -10.84  -31.894 -6.292  1    37.7   ? 274 ARG A N   1 
ATOM   2235 C  CA  . ARG A 1 278 ? -10.699 -32.181 -4.87   1    36.54  ? 274 ARG A CA  1 
ATOM   2236 C  C   . ARG A 1 278 ? -12.088 -32.189 -4.226  1    35.39  ? 274 ARG A C   1 
ATOM   2237 O  O   . ARG A 1 278 ? -12.939 -31.35  -4.506  1    36.28  ? 274 ARG A O   1 
ATOM   2238 C  CB  . ARG A 1 278 ? -9.745  -31.13  -4.303  1    33.39  ? 274 ARG A CB  1 
ATOM   2239 C  CG  . ARG A 1 278 ? -8.987  -31.56  -3.061  1    38.16  ? 274 ARG A CG  1 
ATOM   2240 C  CD  . ARG A 1 278 ? -8.044  -30.469 -2.555  1    35.53  ? 274 ARG A CD  1 
ATOM   2241 N  NE  . ARG A 1 278 ? -6.975  -30.14  -3.512  1    37.45  ? 274 ARG A NE  1 
ATOM   2242 C  CZ  . ARG A 1 278 ? -6.313  -28.987 -3.549  1    36.43  ? 274 ARG A CZ  1 
ATOM   2243 N  NH1 . ARG A 1 278 ? -6.596  -28.004 -2.707  1    36.68  ? 274 ARG A NH1 1 
ATOM   2244 N  NH2 . ARG A 1 278 ? -5.388  -28.814 -4.465  1    34.78  ? 274 ARG A NH2 1 
ATOM   2245 N  N   . ILE A 1 279 ? -12.337 -33.159 -3.373  1    33.47  ? 275 ILE A N   1 
ATOM   2246 C  CA  . ILE A 1 279 ? -13.651 -33.274 -2.772  1    34.5   ? 275 ILE A CA  1 
ATOM   2247 C  C   . ILE A 1 279 ? -13.963 -32.051 -1.902  1    33.31  ? 275 ILE A C   1 
ATOM   2248 O  O   . ILE A 1 279 ? -13.064 -31.474 -1.315  1    38.09  ? 275 ILE A O   1 
ATOM   2249 C  CB  . ILE A 1 279 ? -13.722 -34.61  -2.007  1    35.72  ? 275 ILE A CB  1 
ATOM   2250 C  CG1 . ILE A 1 279 ? -15.157 -34.969 -1.618  1    32.59  ? 275 ILE A CG1 1 
ATOM   2251 C  CG2 . ILE A 1 279 ? -12.758 -34.578 -0.813  1    32.73  ? 275 ILE A CG2 1 
ATOM   2252 C  CD1 . ILE A 1 279 ? -15.315 -36.417 -1.246  1    32.2   ? 275 ILE A CD1 1 
ATOM   2253 N  N   . SER A 1 280 ? -15.248 -31.665 -1.8    1    32.76  ? 276 SER A N   1 
ATOM   2254 C  CA  . SER A 1 280 ? -15.703 -30.605 -0.906  1    29.8   ? 276 SER A CA  1 
ATOM   2255 C  C   . SER A 1 280 ? -15.987 -31.197 0.476   1    33.25  ? 276 SER A C   1 
ATOM   2256 O  O   . SER A 1 280 ? -16.296 -32.379 0.572   1    35.89  ? 276 SER A O   1 
ATOM   2257 C  CB  . SER A 1 280 ? -16.955 -30.007 -1.438  1    32.92  ? 276 SER A CB  1 
ATOM   2258 O  OG  . SER A 1 280 ? -18.039 -30.94  -1.479  1    32.34  ? 276 SER A OG  1 
ATOM   2259 N  N   . ALA A 1 281 ? -15.947 -30.387 1.542   1    31.87  ? 277 ALA A N   1 
ATOM   2260 C  CA  . ALA A 1 281 ? -16.389 -30.855 2.859   1    34.71  ? 277 ALA A CA  1 
ATOM   2261 C  C   . ALA A 1 281 ? -17.817 -31.423 2.831   1    37.73  ? 277 ALA A C   1 
ATOM   2262 O  O   . ALA A 1 281 ? -18.098 -32.458 3.44    1    44.03  ? 277 ALA A O   1 
ATOM   2263 C  CB  . ALA A 1 281 ? -16.276 -29.735 3.888   1    30.97  ? 277 ALA A CB  1 
ATOM   2264 N  N   . LYS A 1 282 ? -18.718 -30.752 2.109   1    35.55  ? 278 LYS A N   1 
ATOM   2265 C  CA  . LYS A 1 282 ? -20.114 -31.155 2.007   1    36.65  ? 278 LYS A CA  1 
ATOM   2266 C  C   . LYS A 1 282 ? -20.198 -32.558 1.404   1    37.5   ? 278 LYS A C   1 
ATOM   2267 O  O   . LYS A 1 282 ? -20.805 -33.467 1.975   1    33.99  ? 278 LYS A O   1 
ATOM   2268 C  CB  . LYS A 1 282 ? -20.826 -29.996 1.296   1    39.19  ? 278 LYS A CB  1 
ATOM   2269 C  CG  . LYS A 1 282 ? -22.281 -30.092 1.017   1    46.45  ? 278 LYS A CG  1 
ATOM   2270 C  CD  . LYS A 1 282 ? -22.851 -28.883 0.261   1    51.18  ? 278 LYS A CD  1 
ATOM   2271 C  CE  . LYS A 1 282 ? -23.303 -27.736 1.116   1    44.94  ? 278 LYS A CE  1 
ATOM   2272 N  NZ  . LYS A 1 282 ? -24.066 -26.767 0.332   1    43.28  ? 278 LYS A NZ  1 
ATOM   2273 N  N   . ALA A 1 283 ? -19.505 -32.787 0.288   1    41.71  ? 279 ALA A N   1 
ATOM   2274 C  CA  . ALA A 1 283 ? -19.588 -34.117 -0.332  1    44.98  ? 279 ALA A CA  1 
ATOM   2275 C  C   . ALA A 1 283 ? -18.869 -35.202 0.497   1    40.75  ? 279 ALA A C   1 
ATOM   2276 O  O   . ALA A 1 283 ? -19.268 -36.358 0.491   1    44.02  ? 279 ALA A O   1 
ATOM   2277 C  CB  . ALA A 1 283 ? -19.067 -34.077 -1.763  1    35.72  ? 279 ALA A CB  1 
ATOM   2278 N  N   . ALA A 1 284 ? -17.818 -34.811 1.219   1    36.56  ? 280 ALA A N   1 
ATOM   2279 C  CA  . ALA A 1 284 ? -16.995 -35.728 1.986   1    36.68  ? 280 ALA A CA  1 
ATOM   2280 C  C   . ALA A 1 284 ? -17.791 -36.316 3.144   1    37.53  ? 280 ALA A C   1 
ATOM   2281 O  O   . ALA A 1 284 ? -17.483 -37.439 3.541   1    37.55  ? 280 ALA A O   1 
ATOM   2282 C  CB  . ALA A 1 284 ? -15.75  -35.027 2.482   1    32.69  ? 280 ALA A CB  1 
ATOM   2283 N  N   . LEU A 1 285 ? -18.806 -35.58  3.639   1    33.82  ? 281 LEU A N   1 
ATOM   2284 C  CA  . LEU A 1 285 ? -19.62  -36.05  4.753   1    36.65  ? 281 LEU A CA  1 
ATOM   2285 C  C   . LEU A 1 285 ? -20.325 -37.35  4.411   1    38.95  ? 281 LEU A C   1 
ATOM   2286 O  O   . LEU A 1 285 ? -20.709 -38.065 5.334   1    42.01  ? 281 LEU A O   1 
ATOM   2287 C  CB  . LEU A 1 285 ? -20.646 -35.019 5.213   1    35.82  ? 281 LEU A CB  1 
ATOM   2288 C  CG  . LEU A 1 285 ? -20.054 -33.777 5.881   1    36.39  ? 281 LEU A CG  1 
ATOM   2289 C  CD1 . LEU A 1 285 ? -21.135 -32.73  6.049   1    34.21  ? 281 LEU A CD1 1 
ATOM   2290 C  CD2 . LEU A 1 285 ? -19.466 -34.166 7.217   1    32.68  ? 281 LEU A CD2 1 
ATOM   2291 N  N   . ALA A 1 286 ? -20.513 -37.622 3.107   1    36.45  ? 282 ALA A N   1 
ATOM   2292 C  CA  . ALA A 1 286 ? -21.312 -38.747 2.633   1    36.44  ? 282 ALA A CA  1 
ATOM   2293 C  C   . ALA A 1 286 ? -20.433 -39.915 2.22    1    36.68  ? 282 ALA A C   1 
ATOM   2294 O  O   . ALA A 1 286 ? -20.951 -40.946 1.765   1    38.43  ? 282 ALA A O   1 
ATOM   2295 C  CB  . ALA A 1 286 ? -22.113 -38.311 1.428   1    38.36  ? 282 ALA A CB  1 
ATOM   2296 N  N   . HIS A 1 287 ? -19.104 -39.728 2.316   1    34.3   ? 283 HIS A N   1 
ATOM   2297 C  CA  . HIS A 1 287 ? -18.186 -40.763 1.883   1    34.24  ? 283 HIS A CA  1 
ATOM   2298 C  C   . HIS A 1 287 ? -18.385 -41.985 2.768   1    36.44  ? 283 HIS A C   1 
ATOM   2299 O  O   . HIS A 1 287 ? -18.599 -41.864 3.98    1    36.99  ? 283 HIS A O   1 
ATOM   2300 C  CB  . HIS A 1 287 ? -16.74  -40.294 1.999   1    32.44  ? 283 HIS A CB  1 
ATOM   2301 C  CG  . HIS A 1 287 ? -15.786 -41.195 1.311   1    34.32  ? 283 HIS A CG  1 
ATOM   2302 N  ND1 . HIS A 1 287 ? -15.358 -42.381 1.874   1    35.74  ? 283 HIS A ND1 1 
ATOM   2303 C  CD2 . HIS A 1 287 ? -15.184 -41.09  0.099   1    34.11  ? 283 HIS A CD2 1 
ATOM   2304 C  CE1 . HIS A 1 287 ? -14.534 -42.988 1.01    1    39.23  ? 283 HIS A CE1 1 
ATOM   2305 N  NE2 . HIS A 1 287 ? -14.397 -42.218 -0.071  1    36.06  ? 283 HIS A NE2 1 
ATOM   2306 N  N   . PRO A 1 288 ? -18.334 -43.18  2.157   1    38.12  ? 284 PRO A N   1 
ATOM   2307 C  CA  . PRO A 1 288 ? -18.521 -44.45  2.874   1    40.35  ? 284 PRO A CA  1 
ATOM   2308 C  C   . PRO A 1 288 ? -17.638 -44.663 4.103   1    41.75  ? 284 PRO A C   1 
ATOM   2309 O  O   . PRO A 1 288 ? -17.995 -45.461 4.985   1    46.27  ? 284 PRO A O   1 
ATOM   2310 C  CB  . PRO A 1 288 ? -18.277 -45.554 1.842   1    38.6   ? 284 PRO A CB  1 
ATOM   2311 C  CG  . PRO A 1 288 ? -18.338 -44.853 0.495   1    38.62  ? 284 PRO A CG  1 
ATOM   2312 C  CD  . PRO A 1 288 ? -18.145 -43.354 0.707   1    37.14  ? 284 PRO A CD  1 
ATOM   2313 N  N   . PHE A 1 289 ? -16.486 -43.973 4.145   1    39.85  ? 285 PHE A N   1 
ATOM   2314 C  CA  . PHE A 1 289 ? -15.601 -44.058 5.292   1    39.06  ? 285 PHE A CA  1 
ATOM   2315 C  C   . PHE A 1 289 ? -16.38  -43.797 6.587   1    39.7   ? 285 PHE A C   1 
ATOM   2316 O  O   . PHE A 1 289 ? -16.076 -44.379 7.629   1    42.46  ? 285 PHE A O   1 
ATOM   2317 C  CB  . PHE A 1 289 ? -14.436 -43.081 5.122   1    37.77  ? 285 PHE A CB  1 
ATOM   2318 C  CG  . PHE A 1 289 ? -13.425 -43.112 6.256   1    39.88  ? 285 PHE A CG  1 
ATOM   2319 C  CD1 . PHE A 1 289 ? -12.577 -44.202 6.448   1    41.24  ? 285 PHE A CD1 1 
ATOM   2320 C  CD2 . PHE A 1 289 ? -13.352 -42.068 7.16    1    39.98  ? 285 PHE A CD2 1 
ATOM   2321 C  CE1 . PHE A 1 289 ? -11.66  -44.219 7.487   1    39.94  ? 285 PHE A CE1 1 
ATOM   2322 C  CE2 . PHE A 1 289 ? -12.407 -42.08  8.187   1    40.45  ? 285 PHE A CE2 1 
ATOM   2323 C  CZ  . PHE A 1 289 ? -11.559 -43.158 8.353   1    38.64  ? 285 PHE A CZ  1 
ATOM   2324 N  N   . PHE A 1 290 ? -17.395 -42.933 6.515   1    38.23  ? 286 PHE A N   1 
ATOM   2325 C  CA  . PHE A 1 290 ? -18.115 -42.515 7.692   1    38.41  ? 286 PHE A CA  1 
ATOM   2326 C  C   . PHE A 1 290 ? -19.357 -43.372 7.962   1    43.57  ? 286 PHE A C   1 
ATOM   2327 O  O   . PHE A 1 290 ? -20.051 -43.084 8.937   1    46.6   ? 286 PHE A O   1 
ATOM   2328 C  CB  . PHE A 1 290 ? -18.453 -41.027 7.579   1    36.96  ? 286 PHE A CB  1 
ATOM   2329 C  CG  . PHE A 1 290 ? -17.25  -40.108 7.467   1    35.77  ? 286 PHE A CG  1 
ATOM   2330 C  CD1 . PHE A 1 290 ? -16.318 -40.038 8.496   1    36.1   ? 286 PHE A CD1 1 
ATOM   2331 C  CD2 . PHE A 1 290 ? -17.059 -39.31  6.345   1    33.59  ? 286 PHE A CD2 1 
ATOM   2332 C  CE1 . PHE A 1 290 ? -15.224 -39.204 8.395   1    34.73  ? 286 PHE A CE1 1 
ATOM   2333 C  CE2 . PHE A 1 290 ? -15.937 -38.518 6.224   1    31.42  ? 286 PHE A CE2 1 
ATOM   2334 C  CZ  . PHE A 1 290 ? -15.04  -38.425 7.267   1    34.1   ? 286 PHE A CZ  1 
ATOM   2335 N  N   . GLN A 1 291 ? -19.616 -44.443 7.189   1    46.14  ? 287 GLN A N   1 
ATOM   2336 C  CA  . GLN A 1 291 ? -20.856 -45.194 7.332   1    54.82  ? 287 GLN A CA  1 
ATOM   2337 C  C   . GLN A 1 291 ? -21.137 -45.568 8.791   1    62.06  ? 287 GLN A C   1 
ATOM   2338 O  O   . GLN A 1 291 ? -22.278 -45.438 9.25    1    76.65  ? 287 GLN A O   1 
ATOM   2339 C  CB  . GLN A 1 291 ? -20.954 -46.406 6.41    1    63.9   ? 287 GLN A CB  1 
ATOM   2340 C  CG  . GLN A 1 291 ? -19.953 -47.515 6.72    1    81.43  ? 287 GLN A CG  1 
ATOM   2341 C  CD  . GLN A 1 291 ? -20.009 -48.681 5.746   1    92.38  ? 287 GLN A CD  1 
ATOM   2342 O  OE1 . GLN A 1 291 ? -20.867 -49.568 5.851   1    94.7   ? 287 GLN A OE1 1 
ATOM   2343 N  NE2 . GLN A 1 291 ? -19.085 -48.701 4.79    1    84.74  ? 287 GLN A NE2 1 
ATOM   2344 N  N   . ASP A 1 292 ? -20.098 -45.965 9.541   1    59.78  ? 288 ASP A N   1 
ATOM   2345 C  CA  . ASP A 1 292 ? -20.244 -46.534 10.883  1    60.29  ? 288 ASP A CA  1 
ATOM   2346 C  C   . ASP A 1 292 ? -19.865 -45.517 11.972  1    57.1   ? 288 ASP A C   1 
ATOM   2347 O  O   . ASP A 1 292 ? -19.651 -45.911 13.122  1    51.76  ? 288 ASP A O   1 
ATOM   2348 C  CB  . ASP A 1 292 ? -19.417 -47.815 11.006  1    64.73  ? 288 ASP A CB  1 
ATOM   2349 C  CG  . ASP A 1 292 ? -17.935 -47.697 10.614  1    75.37  ? 288 ASP A CG  1 
ATOM   2350 O  OD1 . ASP A 1 292 ? -17.498 -46.613 10.046  1    59.76  ? 288 ASP A OD1 1 
ATOM   2351 O  OD2 . ASP A 1 292 ? -17.201 -48.696 10.862  1    79.7   ? 288 ASP A OD2 1 
ATOM   2352 N  N   . VAL A 1 293 ? -19.801 -44.209 11.622  1    55.81  ? 289 VAL A N   1 
ATOM   2353 C  CA  . VAL A 1 293 ? -19.247 -43.178 12.492  1    52.28  ? 289 VAL A CA  1 
ATOM   2354 C  C   . VAL A 1 293 ? -20.1   -42.991 13.756  1    62.81  ? 289 VAL A C   1 
ATOM   2355 O  O   . VAL A 1 293 ? -21.335 -43.122 13.718  1    66.37  ? 289 VAL A O   1 
ATOM   2356 C  CB  . VAL A 1 293 ? -18.986 -41.857 11.759  1    46.17  ? 289 VAL A CB  1 
ATOM   2357 C  CG1 . VAL A 1 293 ? -20.266 -41.139 11.39   1    47.55  ? 289 VAL A CG1 1 
ATOM   2358 C  CG2 . VAL A 1 293 ? -18.123 -40.916 12.571  1    44.13  ? 289 VAL A CG2 1 
ATOM   2359 N  N   . THR A 1 294 ? -19.399 -42.746 14.883  1    62.99  ? 290 THR A N   1 
ATOM   2360 C  CA  . THR A 1 294 ? -19.968 -42.411 16.185  1    64.5   ? 290 THR A CA  1 
ATOM   2361 C  C   . THR A 1 294 ? -19.161 -41.265 16.789  1    60.74  ? 290 THR A C   1 
ATOM   2362 O  O   . THR A 1 294 ? -18.286 -40.719 16.126  1    65.72  ? 290 THR A O   1 
ATOM   2363 C  CB  . THR A 1 294 ? -20.017 -43.627 17.111  1    70.8   ? 290 THR A CB  1 
ATOM   2364 O  OG1 . THR A 1 294 ? -18.701 -44.146 17.301  1    64.33  ? 290 THR A OG1 1 
ATOM   2365 C  CG2 . THR A 1 294 ? -20.956 -44.702 16.583  1    80.9   ? 290 THR A CG2 1 
ATOM   2366 N  N   . LYS A 1 295 ? -19.458 -40.891 18.038  1    61.7   ? 291 LYS A N   1 
ATOM   2367 C  CA  . LYS A 1 295 ? -18.766 -39.784 18.685  1    61.68  ? 291 LYS A CA  1 
ATOM   2368 C  C   . LYS A 1 295 ? -18.262 -40.188 20.078  1    64.23  ? 291 LYS A C   1 
ATOM   2369 O  O   . LYS A 1 295 ? -18.756 -39.685 21.097  1    70.84  ? 291 LYS A O   1 
ATOM   2370 C  CB  . LYS A 1 295 ? -19.685 -38.56  18.782  1    67.83  ? 291 LYS A CB  1 
ATOM   2371 C  CG  . LYS A 1 295 ? -18.992 -37.338 19.384  1    73.4   ? 291 LYS A CG  1 
ATOM   2372 C  CD  . LYS A 1 295 ? -19.951 -36.228 19.804  1    78     ? 291 LYS A CD  1 
ATOM   2373 C  CE  . LYS A 1 295 ? -19.299 -35.275 20.756  1    77.91  ? 291 LYS A CE  1 
ATOM   2374 N  NZ  . LYS A 1 295 ? -20.171 -34.171 21.162  1    77.47  ? 291 LYS A NZ  1 
ATOM   2375 N  N   . PRO A 1 296 ? -17.219 -41.048 20.193  1    62.95  ? 292 PRO A N   1 
ATOM   2376 C  CA  . PRO A 1 296 ? -16.738 -41.441 21.52   1    67.48  ? 292 PRO A CA  1 
ATOM   2377 C  C   . PRO A 1 296 ? -15.906 -40.303 22.135  1    64.06  ? 292 PRO A C   1 
ATOM   2378 O  O   . PRO A 1 296 ? -15.365 -39.466 21.407  1    52.84  ? 292 PRO A O   1 
ATOM   2379 C  CB  . PRO A 1 296 ? -15.944 -42.743 21.219  1    59.58  ? 292 PRO A CB  1 
ATOM   2380 C  CG  . PRO A 1 296 ? -15.446 -42.564 19.792  1    55.26  ? 292 PRO A CG  1 
ATOM   2381 C  CD  . PRO A 1 296 ? -16.402 -41.614 19.094  1    57.24  ? 292 PRO A CD  1 
ATOM   2382 N  N   . VAL A 1 297 ? -15.85  -40.264 23.48   1    64.72  ? 293 VAL A N   1 
ATOM   2383 C  CA  . VAL A 1 297 ? -14.993 -39.342 24.223  1    64.27  ? 293 VAL A CA  1 
ATOM   2384 C  C   . VAL A 1 297 ? -13.538 -39.691 23.934  1    63.09  ? 293 VAL A C   1 
ATOM   2385 O  O   . VAL A 1 297 ? -13.259 -40.831 23.558  1    60.36  ? 293 VAL A O   1 
ATOM   2386 C  CB  . VAL A 1 297 ? -15.228 -39.371 25.746  1    61.4   ? 293 VAL A CB  1 
ATOM   2387 C  CG1 . VAL A 1 297 ? -16.682 -39.095 26.108  1    64.7   ? 293 VAL A CG1 1 
ATOM   2388 C  CG2 . VAL A 1 297 ? -14.717 -40.645 26.403  1    59.14  ? 293 VAL A CG2 1 
ATOM   2389 N  N   . PRO A 1 298 ? -12.573 -38.754 24.127  1    64.51  ? 294 PRO A N   1 
ATOM   2390 C  CA  . PRO A 1 298 ? -11.159 -39.085 23.951  1    64.48  ? 294 PRO A CA  1 
ATOM   2391 C  C   . PRO A 1 298 ? -10.778 -40.078 25.052  1    70.65  ? 294 PRO A C   1 
ATOM   2392 O  O   . PRO A 1 298 ? -11.397 -40.103 26.133  1    69.26  ? 294 PRO A O   1 
ATOM   2393 C  CB  . PRO A 1 298 ? -10.415 -37.739 24.015  1    60.04  ? 294 PRO A CB  1 
ATOM   2394 C  CG  . PRO A 1 298 ? -11.363 -36.798 24.735  1    64.25  ? 294 PRO A CG  1 
ATOM   2395 C  CD  . PRO A 1 298 ? -12.774 -37.352 24.526  1    63.01  ? 294 PRO A CD  1 
ATOM   2396 N  N   . HIS A 1 299 ? -9.743  -40.875 24.739  1    66.75  ? 295 HIS A N   1 
ATOM   2397 C  CA  . HIS A 1 299 ? -9.322  -42.041 25.5    1    65.52  ? 295 HIS A CA  1 
ATOM   2398 C  C   . HIS A 1 299 ? -8.325  -41.688 26.617  1    65.54  ? 295 HIS A C   1 
ATOM   2399 O  O   . HIS A 1 299 ? -7.922  -42.601 27.335  1    62.12  ? 295 HIS A O   1 
ATOM   2400 C  CB  . HIS A 1 299 ? -8.872  -43.148 24.532  1    65.01  ? 295 HIS A CB  1 
ATOM   2401 C  CG  . HIS A 1 299 ? -7.63   -42.876 23.73   1    64.96  ? 295 HIS A CG  1 
ATOM   2402 N  ND1 . HIS A 1 299 ? -6.402  -43.437 24.032  1    69.24  ? 295 HIS A ND1 1 
ATOM   2403 C  CD2 . HIS A 1 299 ? -7.428  -42.094 22.658  1    63.21  ? 295 HIS A CD2 1 
ATOM   2404 C  CE1 . HIS A 1 299 ? -5.497  -43     23.168  1    71.12  ? 295 HIS A CE1 1 
ATOM   2405 N  NE2 . HIS A 1 299 ? -6.099  -42.174 22.326  1    67.84  ? 295 HIS A NE2 1 
ATOM   2406 N  N   . LEU A 1 300 ? -7.978  -40.386 26.804  1    65.34  ? 296 LEU A N   1 
ATOM   2407 C  CA  . LEU A 1 300 ? -6.876  -40.011 27.684  1    70.14  ? 296 LEU A CA  1 
ATOM   2408 C  C   . LEU A 1 300 ? -7.312  -39.027 28.783  1    69.31  ? 296 LEU A C   1 
ATOM   2409 O  O   . LEU A 1 300 ? -8.07   -38.12  28.381  1    73.46  ? 296 LEU A O   1 
ATOM   2410 C  CB  . LEU A 1 300 ? -5.781  -39.438 26.786  1    66.9   ? 296 LEU A CB  1 
ATOM   2411 C  CG  . LEU A 1 300 ? -5.088  -40.444 25.849  1    70.45  ? 296 LEU A CG  1 
ATOM   2412 C  CD1 . LEU A 1 300 ? -3.883  -39.794 25.16   1    70.12  ? 296 LEU A CD1 1 
ATOM   2413 C  CD2 . LEU A 1 300 ? -4.703  -41.798 26.484  1    69.14  ? 296 LEU A CD2 1 
ATOM   2414 N  N   . GLY B 2 1   ? -15.552 -24.192 -11.941 1    39.41  ? 171 GLY B N   1 
ATOM   2415 C  CA  . GLY B 2 1   ? -14.806 -25.026 -10.979 1    40.84  ? 171 GLY B CA  1 
ATOM   2416 C  C   . GLY B 2 1   ? -14.819 -24.389 -9.578  1    41.11  ? 171 GLY B C   1 
ATOM   2417 O  O   . GLY B 2 1   ? -15.628 -23.486 -9.291  1    38.64  ? 171 GLY B O   1 
ATOM   2418 N  N   . VAL B 2 2   ? -13.858 -24.827 -8.749  1    39.67  ? 172 VAL B N   1 
ATOM   2419 C  CA  . VAL B 2 2   ? -13.844 -24.505 -7.34   1    45.71  ? 172 VAL B CA  1 
ATOM   2420 C  C   . VAL B 2 2   ? -13.778 -22.991 -7.058  1    46.23  ? 172 VAL B C   1 
ATOM   2421 O  O   . VAL B 2 2   ? -14.18  -22.555 -5.982  1    47.15  ? 172 VAL B O   1 
ATOM   2422 C  CB  . VAL B 2 2   ? -12.757 -25.316 -6.617  1    47.06  ? 172 VAL B CB  1 
ATOM   2423 C  CG1 . VAL B 2 2   ? -11.387 -24.7   -6.883  1    46.18  ? 172 VAL B CG1 1 
ATOM   2424 C  CG2 . VAL B 2 2   ? -13.082 -25.427 -5.119  1    42.03  ? 172 VAL B CG2 1 
ATOM   2425 N  N   . ASN B 2 3   ? -13.307 -22.178 -8.01   1    44.98  ? 173 ASN B N   1 
ATOM   2426 C  CA  . ASN B 2 3   ? -13.187 -20.736 -7.789  1    40.94  ? 173 ASN B CA  1 
ATOM   2427 C  C   . ASN B 2 3   ? -14.576 -20.108 -7.748  1    38.17  ? 173 ASN B C   1 
ATOM   2428 O  O   . ASN B 2 3   ? -14.737 -19     -7.227  1    38.33  ? 173 ASN B O   1 
ATOM   2429 C  CB  . ASN B 2 3   ? -12.26  -20.032 -8.791  1    41     ? 173 ASN B CB  1 
ATOM   2430 C  CG  . ASN B 2 3   ? -10.816 -20.497 -8.7    1    45.95  ? 173 ASN B CG  1 
ATOM   2431 O  OD1 . ASN B 2 3   ? -10.388 -21.014 -7.652  1    47.34  ? 173 ASN B OD1 1 
ATOM   2432 N  ND2 . ASN B 2 3   ? -10.044 -20.375 -9.78   1    42.45  ? 173 ASN B ND2 1 
ATOM   2433 N  N   . GLU B 2 4   ? -15.559 -20.801 -8.339  1    41.48  ? 174 GLU B N   1 
ATOM   2434 C  CA  . GLU B 2 4   ? -16.962 -20.39  -8.311  1    43.27  ? 174 GLU B CA  1 
ATOM   2435 C  C   . GLU B 2 4   ? -17.726 -21.25  -7.302  1    39.77  ? 174 GLU B C   1 
ATOM   2436 O  O   . GLU B 2 4   ? -18.94  -21.246 -7.328  1    41.07  ? 174 GLU B O   1 
ATOM   2437 C  CB  . GLU B 2 4   ? -17.61  -20.556 -9.692  1    45.09  ? 174 GLU B CB  1 
ATOM   2438 C  CG  . GLU B 2 4   ? -16.633 -20.295 -10.831 1    52.75  ? 174 GLU B CG  1 
ATOM   2439 C  CD  . GLU B 2 4   ? -17.181 -20.225 -12.246 1    64.46  ? 174 GLU B CD  1 
ATOM   2440 O  OE1 . GLU B 2 4   ? -18.021 -21.087 -12.623 1    68.3   ? 174 GLU B OE1 1 
ATOM   2441 O  OE2 . GLU B 2 4   ? -16.727 -19.323 -12.989 1    62.85  ? 174 GLU B OE2 1 
ATOM   2442 N  N   . VAL B 2 5   ? -17.009 -22.025 -6.48   1    37.86  ? 175 VAL B N   1 
ATOM   2443 C  CA  . VAL B 2 5   ? -17.539 -22.837 -5.395  1    42.47  ? 175 VAL B CA  1 
ATOM   2444 C  C   . VAL B 2 5   ? -18.909 -23.425 -5.74   1    43.88  ? 175 VAL B C   1 
ATOM   2445 O  O   . VAL B 2 5   ? -19.894 -23.135 -5.054  1    43.49  ? 175 VAL B O   1 
ATOM   2446 C  CB  . VAL B 2 5   ? -17.598 -22.113 -4.036  1    39.09  ? 175 VAL B CB  1 
ATOM   2447 C  CG1 . VAL B 2 5   ? -16.2   -21.825 -3.519  1    37.85  ? 175 VAL B CG1 1 
ATOM   2448 C  CG2 . VAL B 2 5   ? -18.467 -20.85  -4.089  1    36.67  ? 175 VAL B CG2 1 
ATOM   2449 N  N   . PRO B 2 6   ? -18.988 -24.328 -6.738  1    45.6   ? 176 PRO B N   1 
ATOM   2450 C  CA  . PRO B 2 6   ? -20.241 -25.003 -7.08   1    46.38  ? 176 PRO B CA  1 
ATOM   2451 C  C   . PRO B 2 6   ? -21.032 -25.593 -5.906  1    43.95  ? 176 PRO B C   1 
ATOM   2452 O  O   . PRO B 2 6   ? -22.26  -25.524 -5.913  1    46.05  ? 176 PRO B O   1 
ATOM   2453 C  CB  . PRO B 2 6   ? -19.838 -26.078 -8.132  1    42.98  ? 176 PRO B CB  1 
ATOM   2454 C  CG  . PRO B 2 6   ? -18.321 -26.097 -8.116  1    44.49  ? 176 PRO B CG  1 
ATOM   2455 C  CD  . PRO B 2 6   ? -17.855 -24.76  -7.58   1    45.43  ? 176 PRO B CD  1 
ATOM   2456 N  N   . ASP B 2 7   ? -20.355 -26.159 -4.903  1    40.77  ? 177 ASP B N   1 
ATOM   2457 C  CA  . ASP B 2 7   ? -21.035 -26.847 -3.819  1    41.01  ? 177 ASP B CA  1 
ATOM   2458 C  C   . ASP B 2 7   ? -21.546 -25.885 -2.748  1    40.08  ? 177 ASP B C   1 
ATOM   2459 O  O   . ASP B 2 7   ? -22.185 -26.339 -1.805  1    41.78  ? 177 ASP B O   1 
ATOM   2460 C  CB  . ASP B 2 7   ? -20.158 -27.884 -3.142  1    41.59  ? 177 ASP B CB  1 
ATOM   2461 C  CG  . ASP B 2 7   ? -20.081 -29.204 -3.88   1    48.07  ? 177 ASP B CG  1 
ATOM   2462 O  OD1 . ASP B 2 7   ? -20.443 -29.223 -5.101  1    51.77  ? 177 ASP B OD1 1 
ATOM   2463 O  OD2 . ASP B 2 7   ? -19.682 -30.204 -3.232  1    48.61  ? 177 ASP B OD2 1 
ATOM   2464 N  N   . TYR B 2 8   ? -21.237 -24.589 -2.871  1    34.58  ? 178 TYR B N   1 
ATOM   2465 C  CA  . TYR B 2 8   ? -21.542 -23.623 -1.824  1    33.39  ? 178 TYR B CA  1 
ATOM   2466 C  C   . TYR B 2 8   ? -22.207 -22.358 -2.377  1    33.77  ? 178 TYR B C   1 
ATOM   2467 O  O   . TYR B 2 8   ? -22.675 -21.558 -1.579  1    35.9   ? 178 TYR B O   1 
ATOM   2468 C  CB  . TYR B 2 8   ? -20.28  -23.274 -1.006  1    32.45  ? 178 TYR B CB  1 
ATOM   2469 C  CG  . TYR B 2 8   ? -19.632 -24.465 -0.322  1    32.29  ? 178 TYR B CG  1 
ATOM   2470 C  CD1 . TYR B 2 8   ? -20.178 -24.988 0.861   1    30.58  ? 178 TYR B CD1 1 
ATOM   2471 C  CD2 . TYR B 2 8   ? -18.517 -25.108 -0.876  1    32.79  ? 178 TYR B CD2 1 
ATOM   2472 C  CE1 . TYR B 2 8   ? -19.634 -26.102 1.474   1    29.6   ? 178 TYR B CE1 1 
ATOM   2473 C  CE2 . TYR B 2 8   ? -17.948 -26.23  -0.267  1    31.29  ? 178 TYR B CE2 1 
ATOM   2474 C  CZ  . TYR B 2 8   ? -18.511 -26.716 0.916   1    31.68  ? 178 TYR B CZ  1 
ATOM   2475 O  OH  . TYR B 2 8   ? -17.978 -27.809 1.563   1    32.44  ? 178 TYR B OH  1 
ATOM   2476 N  N   . HIS B 2 9   ? -22.302 -22.162 -3.709  1    36.12  ? 179 HIS B N   1 
ATOM   2477 C  CA  . HIS B 2 9   ? -22.741 -20.864 -4.223  1    39.92  ? 179 HIS B CA  1 
ATOM   2478 C  C   . HIS B 2 9   ? -24.18  -20.596 -3.777  1    37.23  ? 179 HIS B C   1 
ATOM   2479 O  O   . HIS B 2 9   ? -24.515 -19.474 -3.471  1    33.34  ? 179 HIS B O   1 
ATOM   2480 C  CB  . HIS B 2 9   ? -22.47  -20.653 -5.729  1    46.88  ? 179 HIS B CB  1 
ATOM   2481 C  CG  . HIS B 2 9   ? -23.368 -21.374 -6.694  1    62.18  ? 179 HIS B CG  1 
ATOM   2482 N  ND1 . HIS B 2 9   ? -23.045 -22.583 -7.293  1    76.59  ? 179 HIS B ND1 1 
ATOM   2483 C  CD2 . HIS B 2 9   ? -24.584 -21.08  -7.153  1    70.62  ? 179 HIS B CD2 1 
ATOM   2484 C  CE1 . HIS B 2 9   ? -24.03  -23.01  -8.077  1    64.47  ? 179 HIS B CE1 1 
ATOM   2485 N  NE2 . HIS B 2 9   ? -24.984 -22.112 -7.999  1    79.34  ? 179 HIS B NE2 1 
ATOM   2486 N  N   . GLU B 2 10  ? -25.037 -21.631 -3.746  1    39.05  ? 180 GLU B N   1 
ATOM   2487 C  CA  . GLU B 2 10  ? -26.429 -21.459 -3.373  1    38.21  ? 180 GLU B CA  1 
ATOM   2488 C  C   . GLU B 2 10  ? -26.549 -21.11  -1.883  1    38.16  ? 180 GLU B C   1 
ATOM   2489 O  O   . GLU B 2 10  ? -27.196 -20.124 -1.505  1    37.82  ? 180 GLU B O   1 
ATOM   2490 C  CB  . GLU B 2 10  ? -27.189 -22.693 -3.822  1    42.83  ? 180 GLU B CB  1 
ATOM   2491 C  CG  . GLU B 2 10  ? -28.708 -22.528 -3.718  1    54.71  ? 180 GLU B CG  1 
ATOM   2492 C  CD  . GLU B 2 10  ? -29.496 -23.757 -4.157  1    61.96  ? 180 GLU B CD  1 
ATOM   2493 O  OE1 . GLU B 2 10  ? -30.569 -24.009 -3.581  1    66.58  ? 180 GLU B OE1 1 
ATOM   2494 O  OE2 . GLU B 2 10  ? -29.018 -24.479 -5.063  1    77.52  ? 180 GLU B OE2 1 
ATOM   2495 N  N   . ASP B 2 11  ? -25.909 -21.915 -1.034  1    34.28  ? 181 ASP B N   1 
ATOM   2496 C  CA  . ASP B 2 11  ? -25.855 -21.615 0.386   1    36.01  ? 181 ASP B CA  1 
ATOM   2497 C  C   . ASP B 2 11  ? -25.376 -20.183 0.631   1    36.69  ? 181 ASP B C   1 
ATOM   2498 O  O   . ASP B 2 11  ? -25.877 -19.508 1.524   1    38.91  ? 181 ASP B O   1 
ATOM   2499 C  CB  . ASP B 2 11  ? -24.938 -22.572 1.127   1    38.09  ? 181 ASP B CB  1 
ATOM   2500 C  CG  . ASP B 2 11  ? -25.388 -24.016 1.245   1    41.73  ? 181 ASP B CG  1 
ATOM   2501 O  OD1 . ASP B 2 11  ? -26.577 -24.287 0.933   1    44.19  ? 181 ASP B OD1 1 
ATOM   2502 O  OD2 . ASP B 2 11  ? -24.541 -24.85  1.648   1    41.38  ? 181 ASP B OD2 1 
ATOM   2503 N  N   . ILE B 2 12  ? -24.347 -19.736 -0.107  1    35.37  ? 182 ILE B N   1 
ATOM   2504 C  CA  . ILE B 2 12  ? -23.778 -18.435 0.145   1    36.07  ? 182 ILE B CA  1 
ATOM   2505 C  C   . ILE B 2 12  ? -24.764 -17.342 -0.264  1    35.74  ? 182 ILE B C   1 
ATOM   2506 O  O   . ILE B 2 12  ? -24.986 -16.39  0.491   1    36.68  ? 182 ILE B O   1 
ATOM   2507 C  CB  . ILE B 2 12  ? -22.408 -18.274 -0.536  1    37.38  ? 182 ILE B CB  1 
ATOM   2508 C  CG1 . ILE B 2 12  ? -21.378 -19.182 0.145   1    36.77  ? 182 ILE B CG1 1 
ATOM   2509 C  CG2 . ILE B 2 12  ? -21.963 -16.796 -0.547  1    32     ? 182 ILE B CG2 1 
ATOM   2510 C  CD1 . ILE B 2 12  ? -20.096 -19.358 -0.668  1    35.36  ? 182 ILE B CD1 1 
ATOM   2511 N  N   . HIS B 2 13  ? -25.323 -17.468 -1.471  1    32.96  ? 183 HIS B N   1 
ATOM   2512 C  CA  . HIS B 2 13  ? -26.314 -16.531 -1.965  1    30.56  ? 183 HIS B CA  1 
ATOM   2513 C  C   . HIS B 2 13  ? -27.464 -16.401 -0.952  1    32.59  ? 183 HIS B C   1 
ATOM   2514 O  O   . HIS B 2 13  ? -27.814 -15.307 -0.533  1    33.82  ? 183 HIS B O   1 
ATOM   2515 C  CB  . HIS B 2 13  ? -26.78  -16.984 -3.347  1    32.33  ? 183 HIS B CB  1 
ATOM   2516 C  CG  . HIS B 2 13  ? -27.917 -16.166 -3.806  1    35.32  ? 183 HIS B CG  1 
ATOM   2517 N  ND1 . HIS B 2 13  ? -27.684 -14.921 -4.348  1    38.79  ? 183 HIS B ND1 1 
ATOM   2518 C  CD2 . HIS B 2 13  ? -29.242 -16.311 -3.744  1    32.22  ? 183 HIS B CD2 1 
ATOM   2519 C  CE1 . HIS B 2 13  ? -28.838 -14.344 -4.637  1    36.84  ? 183 HIS B CE1 1 
ATOM   2520 N  NE2 . HIS B 2 13  ? -29.783 -15.184 -4.288  1    36.25  ? 183 HIS B NE2 1 
ATOM   2521 N  N   . THR B 2 14  ? -28.045 -17.519 -0.521  1    34.29  ? 184 THR B N   1 
ATOM   2522 C  CA  . THR B 2 14  ? -29.078 -17.521 0.508   1    37.86  ? 184 THR B CA  1 
ATOM   2523 C  C   . THR B 2 14  ? -28.621 -16.799 1.771   1    41.26  ? 184 THR B C   1 
ATOM   2524 O  O   . THR B 2 14  ? -29.391 -16.045 2.354   1    43.73  ? 184 THR B O   1 
ATOM   2525 C  CB  . THR B 2 14  ? -29.415 -18.941 0.935   1    39.34  ? 184 THR B CB  1 
ATOM   2526 O  OG1 . THR B 2 14  ? -30.245 -19.541 -0.049  1    39.18  ? 184 THR B OG1 1 
ATOM   2527 C  CG2 . THR B 2 14  ? -30.133 -18.949 2.272   1    41.03  ? 184 THR B CG2 1 
ATOM   2528 N  N   . TYR B 2 15  ? -27.398 -17.078 2.238   1    39.54  ? 185 TYR B N   1 
ATOM   2529 C  CA  . TYR B 2 15  ? -26.931 -16.475 3.478   1    35.98  ? 185 TYR B CA  1 
ATOM   2530 C  C   . TYR B 2 15  ? -26.761 -14.96  3.33    1    32.81  ? 185 TYR B C   1 
ATOM   2531 O  O   . TYR B 2 15  ? -27.102 -14.227 4.247   1    32.94  ? 185 TYR B O   1 
ATOM   2532 C  CB  . TYR B 2 15  ? -25.643 -17.147 3.937   1    36.4   ? 185 TYR B CB  1 
ATOM   2533 C  CG  . TYR B 2 15  ? -25.097 -16.547 5.214   1    38.79  ? 185 TYR B CG  1 
ATOM   2534 C  CD1 . TYR B 2 15  ? -25.806 -16.64  6.412   1    41.28  ? 185 TYR B CD1 1 
ATOM   2535 C  CD2 . TYR B 2 15  ? -23.89  -15.88  5.222   1    37.4   ? 185 TYR B CD2 1 
ATOM   2536 C  CE1 . TYR B 2 15  ? -25.319 -16.093 7.588   1    38.56  ? 185 TYR B CE1 1 
ATOM   2537 C  CE2 . TYR B 2 15  ? -23.371 -15.356 6.399   1    39.66  ? 185 TYR B CE2 1 
ATOM   2538 C  CZ  . TYR B 2 15  ? -24.084 -15.473 7.58    1    41.67  ? 185 TYR B CZ  1 
ATOM   2539 O  OH  . TYR B 2 15  ? -23.591 -14.947 8.725   1    41.05  ? 185 TYR B OH  1 
ATOM   2540 N  N   . LEU B 2 16  ? -26.245 -14.501 2.184   1    31.1   ? 186 LEU B N   1 
ATOM   2541 C  CA  . LEU B 2 16  ? -26.099 -13.086 1.896   1    29.68  ? 186 LEU B CA  1 
ATOM   2542 C  C   . LEU B 2 16  ? -27.461 -12.404 1.833   1    34.75  ? 186 LEU B C   1 
ATOM   2543 O  O   . LEU B 2 16  ? -27.597 -11.231 2.226   1    37.43  ? 186 LEU B O   1 
ATOM   2544 C  CB  . LEU B 2 16  ? -25.351 -12.892 0.595   1    28.84  ? 186 LEU B CB  1 
ATOM   2545 C  CG  . LEU B 2 16  ? -23.906 -13.387 0.533   1    31.57  ? 186 LEU B CG  1 
ATOM   2546 C  CD1 . LEU B 2 16  ? -23.325 -13.203 -0.859  1    32.3   ? 186 LEU B CD1 1 
ATOM   2547 C  CD2 . LEU B 2 16  ? -23.07  -12.648 1.566   1    30.59  ? 186 LEU B CD2 1 
ATOM   2548 N  N   . ARG B 2 17  ? -28.483 -13.124 1.353   1    36.7   ? 187 ARG B N   1 
ATOM   2549 C  CA  . ARG B 2 17  ? -29.823 -12.542 1.265   1    38.6   ? 187 ARG B CA  1 
ATOM   2550 C  C   . ARG B 2 17  ? -30.353 -12.266 2.671   1    37.43  ? 187 ARG B C   1 
ATOM   2551 O  O   . ARG B 2 17  ? -31.027 -11.282 2.93    1    38.96  ? 187 ARG B O   1 
ATOM   2552 C  CB  . ARG B 2 17  ? -30.751 -13.441 0.446   1    34.43  ? 187 ARG B CB  1 
ATOM   2553 C  CG  . ARG B 2 17  ? -30.466 -13.381 -1.052  1    35.42  ? 187 ARG B CG  1 
ATOM   2554 C  CD  . ARG B 2 17  ? -30.983 -12.094 -1.676  1    34.85  ? 187 ARG B CD  1 
ATOM   2555 N  NE  . ARG B 2 17  ? -32.438 -12.017 -1.518  1    32.56  ? 187 ARG B NE  1 
ATOM   2556 C  CZ  . ARG B 2 17  ? -33.329 -12.506 -2.35   1    33.29  ? 187 ARG B CZ  1 
ATOM   2557 N  NH1 . ARG B 2 17  ? -32.982 -12.924 -3.555  1    37.24  ? 187 ARG B NH1 1 
ATOM   2558 N  NH2 . ARG B 2 17  ? -34.599 -12.511 -2.017  1    31.71  ? 187 ARG B NH2 1 
ATOM   2559 N  N   . GLU B 2 18  ? -30.05  -13.164 3.594   1    40.69  ? 188 GLU B N   1 
ATOM   2560 C  CA  . GLU B 2 18  ? -30.436 -12.98  4.982   1    44.93  ? 188 GLU B CA  1 
ATOM   2561 C  C   . GLU B 2 18  ? -29.628 -11.82  5.596   1    42.76  ? 188 GLU B C   1 
ATOM   2562 O  O   . GLU B 2 18  ? -30.173 -10.938 6.233   1    41.14  ? 188 GLU B O   1 
ATOM   2563 C  CB  . GLU B 2 18  ? -30.367 -14.371 5.625   1    43.97  ? 188 GLU B CB  1 
ATOM   2564 C  CG  . GLU B 2 18  ? -30.303 -14.347 7.15    1    58.72  ? 188 GLU B CG  1 
ATOM   2565 C  CD  . GLU B 2 18  ? -30.13  -15.752 7.713   1    73.31  ? 188 GLU B CD  1 
ATOM   2566 O  OE1 . GLU B 2 18  ? -29.963 -16.696 6.86    1    73.37  ? 188 GLU B OE1 1 
ATOM   2567 O  OE2 . GLU B 2 18  ? -30.184 -15.906 8.968   1    67.41  ? 188 GLU B OE2 1 
ATOM   2568 N  N   . MET B 2 19  ? -28.321 -11.79  5.359   1    38.31  ? 189 MET B N   1 
ATOM   2569 C  CA  . MET B 2 19  ? -27.472 -10.84  6.039   1    42.2   ? 189 MET B CA  1 
ATOM   2570 C  C   . MET B 2 19  ? -27.715 -9.405  5.549   1    43.21  ? 189 MET B C   1 
ATOM   2571 O  O   . MET B 2 19  ? -27.618 -8.467  6.351   1    42.3   ? 189 MET B O   1 
ATOM   2572 C  CB  . MET B 2 19  ? -26.005 -11.251 5.869   1    37.21  ? 189 MET B CB  1 
ATOM   2573 C  CG  . MET B 2 19  ? -25.611 -12.452 6.719   1    45.27  ? 189 MET B CG  1 
ATOM   2574 S  SD  . MET B 2 19  ? -26.244 -12.536 8.411   1    52.41  ? 189 MET B SD  1 
ATOM   2575 C  CE  . MET B 2 19  ? -25.267 -11.294 9.265   1    54.33  ? 189 MET B CE  1 
ATOM   2576 N  N   . GLU B 2 20  ? -28.007 -9.224  4.253   1    36.73  ? 190 GLU B N   1 
ATOM   2577 C  CA  . GLU B 2 20  ? -28.19  -7.889  3.705   1    35.36  ? 190 GLU B CA  1 
ATOM   2578 C  C   . GLU B 2 20  ? -29.339 -7.178  4.415   1    34.6   ? 190 GLU B C   1 
ATOM   2579 O  O   . GLU B 2 20  ? -29.299 -5.959  4.549   1    36.66  ? 190 GLU B O   1 
ATOM   2580 C  CB  . GLU B 2 20  ? -28.31  -7.848  2.174   1    32.14  ? 190 GLU B CB  1 
ATOM   2581 C  CG  . GLU B 2 20  ? -29.686 -8.229  1.629   1    35.81  ? 190 GLU B CG  1 
ATOM   2582 C  CD  . GLU B 2 20  ? -29.77  -8.13   0.106   1    39.34  ? 190 GLU B CD  1 
ATOM   2583 O  OE1 . GLU B 2 20  ? -28.892 -7.444  -0.513  1    37.41  ? 190 GLU B OE1 1 
ATOM   2584 O  OE2 . GLU B 2 20  ? -30.662 -8.804  -0.458  1    34.48  ? 190 GLU B OE2 1 
ATOM   2585 N  N   . VAL B 2 21  ? -30.366 -7.934  4.819   1    35.84  ? 191 VAL B N   1 
ATOM   2586 C  CA  . VAL B 2 21  ? -31.481 -7.436  5.608   1    38.08  ? 191 VAL B CA  1 
ATOM   2587 C  C   . VAL B 2 21  ? -31.008 -7.019  7.012   1    45.57  ? 191 VAL B C   1 
ATOM   2588 O  O   . VAL B 2 21  ? -31.465 -6.009  7.533   1    53.64  ? 191 VAL B O   1 
ATOM   2589 C  CB  . VAL B 2 21  ? -32.629 -8.469  5.695   1    38.02  ? 191 VAL B CB  1 
ATOM   2590 C  CG1 . VAL B 2 21  ? -33.769 -8.007  6.602   1    35.72  ? 191 VAL B CG1 1 
ATOM   2591 C  CG2 . VAL B 2 21  ? -33.197 -8.831  4.335   1    34.99  ? 191 VAL B CG2 1 
ATOM   2592 N  N   . LYS B 2 22  ? -30.108 -7.779  7.649   1    51.87  ? 192 LYS B N   1 
ATOM   2593 C  CA  . LYS B 2 22  ? -29.63  -7.411  8.979   1    60.93  ? 192 LYS B CA  1 
ATOM   2594 C  C   . LYS B 2 22  ? -28.637 -6.257  8.89    1    52     ? 192 LYS B C   1 
ATOM   2595 O  O   . LYS B 2 22  ? -28.472 -5.534  9.85    1    60.08  ? 192 LYS B O   1 
ATOM   2596 C  CB  . LYS B 2 22  ? -28.98  -8.546  9.786   1    71.7   ? 192 LYS B CB  1 
ATOM   2597 C  CG  . LYS B 2 22  ? -29.939 -9.663  10.203  1    99.05  ? 192 LYS B CG  1 
ATOM   2598 C  CD  . LYS B 2 22  ? -29.325 -10.826 10.99   1    91.79  ? 192 LYS B CD  1 
ATOM   2599 C  CE  . LYS B 2 22  ? -30.356 -11.87  11.378  1    97.35  ? 192 LYS B CE  1 
ATOM   2600 N  NZ  . LYS B 2 22  ? -29.847 -13.033 12.116  1    79.42  ? 192 LYS B NZ  1 
ATOM   2601 N  N   . CYS B 2 23  ? -27.978 -6.094  7.743   1    52.48  ? 193 CYS B N   1 
ATOM   2602 C  CA  . CYS B 2 23  ? -26.982 -5.04   7.563   1    50.55  ? 193 CYS B CA  1 
ATOM   2603 C  C   . CYS B 2 23  ? -27.579 -3.813  6.878   1    52.05  ? 193 CYS B C   1 
ATOM   2604 O  O   . CYS B 2 23  ? -26.814 -2.966  6.401   1    51.63  ? 193 CYS B O   1 
ATOM   2605 C  CB  . CYS B 2 23  ? -25.813 -5.542  6.717   1    40.24  ? 193 CYS B CB  1 
ATOM   2606 S  SG  . CYS B 2 23  ? -24.728 -6.653  7.674   1    57.37  ? 193 CYS B SG  1 
ATOM   2607 N  N   . LYS B 2 24  ? -28.925 -3.752  6.792   1    46.52  ? 194 LYS B N   1 
ATOM   2608 C  CA  . LYS B 2 24  ? -29.578 -2.692  6.05    1    44.83  ? 194 LYS B CA  1 
ATOM   2609 C  C   . LYS B 2 24  ? -29.597 -1.427  6.906   1    46.29  ? 194 LYS B C   1 
ATOM   2610 O  O   . LYS B 2 24  ? -29.955 -1.438  8.084   1    49.71  ? 194 LYS B O   1 
ATOM   2611 C  CB  . LYS B 2 24  ? -31.001 -3.059  5.633   1    52.12  ? 194 LYS B CB  1 
ATOM   2612 C  CG  . LYS B 2 24  ? -31.489 -2.268  4.42    1    59.56  ? 194 LYS B CG  1 
ATOM   2613 C  CD  . LYS B 2 24  ? -32.996 -2.036  4.393   1    67.05  ? 194 LYS B CD  1 
ATOM   2614 C  CE  . LYS B 2 24  ? -33.495 -1.076  3.313   1    70.7   ? 194 LYS B CE  1 
ATOM   2615 N  NZ  . LYS B 2 24  ? -33.777 -1.71   2.014   1    72.49  ? 194 LYS B NZ  1 
ATOM   2616 N  N   . PRO B 2 25  ? -29.236 -0.259  6.322   1    43.91  ? 195 PRO B N   1 
ATOM   2617 C  CA  . PRO B 2 25  ? -29.361 0.984   7.051   1    45.54  ? 195 PRO B CA  1 
ATOM   2618 C  C   . PRO B 2 25  ? -30.799 1.464   7.112   1    45.34  ? 195 PRO B C   1 
ATOM   2619 O  O   . PRO B 2 25  ? -31.652 0.942   6.387   1    52.86  ? 195 PRO B O   1 
ATOM   2620 C  CB  . PRO B 2 25  ? -28.48  1.894   6.193   1    47.29  ? 195 PRO B CB  1 
ATOM   2621 C  CG  . PRO B 2 25  ? -27.566 0.96    5.459   1    43.56  ? 195 PRO B CG  1 
ATOM   2622 C  CD  . PRO B 2 25  ? -28.596 -0.033  5.01    1    42.96  ? 195 PRO B CD  1 
ATOM   2623 N  N   . LYS B 2 26  ? -31.068 2.442   7.97    1    47.42  ? 196 LYS B N   1 
ATOM   2624 C  CA  . LYS B 2 26  ? -32.417 3.044   8.057   1    53.59  ? 196 LYS B CA  1 
ATOM   2625 C  C   . LYS B 2 26  ? -32.635 3.941   6.84    1    56.84  ? 196 LYS B C   1 
ATOM   2626 O  O   . LYS B 2 26  ? -31.82  4.847   6.626   1    58.39  ? 196 LYS B O   1 
ATOM   2627 C  CB  . LYS B 2 26  ? -32.498 3.859   9.344   1    60.93  ? 196 LYS B CB  1 
ATOM   2628 C  CG  . LYS B 2 26  ? -32.445 3.078   10.643  1    85.28  ? 196 LYS B CG  1 
ATOM   2629 C  CD  . LYS B 2 26  ? -32.509 3.988   11.864  1    81.97  ? 196 LYS B CD  1 
ATOM   2630 C  CE  . LYS B 2 26  ? -32.481 3.232   13.153  1    81.32  ? 196 LYS B CE  1 
ATOM   2631 N  NZ  . LYS B 2 26  ? -32.521 4.136   14.303  1    91.88  ? 196 LYS B NZ  1 
ATOM   2632 N  N   . VAL B 2 27  ? -33.71  3.71    6.093   1    63.85  ? 197 VAL B N   1 
ATOM   2633 C  CA  . VAL B 2 27  ? -33.96  4.462   4.829   1    59.9   ? 197 VAL B CA  1 
ATOM   2634 C  C   . VAL B 2 27  ? -34.141 5.958   5.11    1    59.02  ? 197 VAL B C   1 
ATOM   2635 O  O   . VAL B 2 27  ? -33.815 6.765   4.225   1    57.7   ? 197 VAL B O   1 
ATOM   2636 C  CB  . VAL B 2 27  ? -35.195 3.855   4.141   1    59.64  ? 197 VAL B CB  1 
ATOM   2637 C  CG1 . VAL B 2 27  ? -35.46  4.477   2.779   1    57.79  ? 197 VAL B CG1 1 
ATOM   2638 C  CG2 . VAL B 2 27  ? -35.09  2.341   4.033   1    62.06  ? 197 VAL B CG2 1 
ATOM   2639 N  N   . GLY B 2 28  ? -34.606 6.32    6.297   1    52.99  ? 198 GLY B N   1 
ATOM   2640 C  CA  . GLY B 2 28  ? -34.888 7.748   6.537   1    66.95  ? 198 GLY B CA  1 
ATOM   2641 C  C   . GLY B 2 28  ? -34.003 8.367   7.589   1    68.19  ? 198 GLY B C   1 
ATOM   2642 O  O   . GLY B 2 28  ? -34.54  9.1     8.435   1    72.38  ? 198 GLY B O   1 
ATOM   2643 N  N   . TYR B 2 29  ? -32.7   8.121   7.529   1    58.18  ? 199 TYR B N   1 
ATOM   2644 C  CA  . TYR B 2 29  ? -31.807 8.61    8.608   1    52.13  ? 199 TYR B CA  1 
ATOM   2645 C  C   . TYR B 2 29  ? -31.458 10.069  8.363   1    51.99  ? 199 TYR B C   1 
ATOM   2646 O  O   . TYR B 2 29  ? -31.24  10.775  9.354   1    55.86  ? 199 TYR B O   1 
ATOM   2647 C  CB  . TYR B 2 29  ? -30.612 7.653   8.742   1    47.15  ? 199 TYR B CB  1 
ATOM   2648 C  CG  . TYR B 2 29  ? -29.435 7.763   7.785   1    41.99  ? 199 TYR B CG  1 
ATOM   2649 C  CD1 . TYR B 2 29  ? -28.641 8.9     7.74    1    44.98  ? 199 TYR B CD1 1 
ATOM   2650 C  CD2 . TYR B 2 29  ? -29.087 6.701   6.965   1    43.25  ? 199 TYR B CD2 1 
ATOM   2651 C  CE1 . TYR B 2 29  ? -27.572 8.998   6.87    1    47     ? 199 TYR B CE1 1 
ATOM   2652 C  CE2 . TYR B 2 29  ? -28.008 6.779   6.102   1    45.52  ? 199 TYR B CE2 1 
ATOM   2653 C  CZ  . TYR B 2 29  ? -27.248 7.931   6.057   1    47.3   ? 199 TYR B CZ  1 
ATOM   2654 O  OH  . TYR B 2 29  ? -26.185 8.024   5.214   1    46.8   ? 199 TYR B OH  1 
ATOM   2655 N  N   . MET B 2 30  ? -31.433 10.513  7.107   1    49.18  ? 200 MET B N   1 
ATOM   2656 C  CA  . MET B 2 30  ? -30.963 11.892  6.807   1    51.88  ? 200 MET B CA  1 
ATOM   2657 C  C   . MET B 2 30  ? -31.917 12.936  7.4     1    56.39  ? 200 MET B C   1 
ATOM   2658 O  O   . MET B 2 30  ? -31.432 13.965  7.884   1    56.42  ? 200 MET B O   1 
ATOM   2659 C  CB  . MET B 2 30  ? -30.804 12.099  5.301   1    52.76  ? 200 MET B CB  1 
ATOM   2660 C  CG  . MET B 2 30  ? -29.663 13.015  4.94    1    58.19  ? 200 MET B CG  1 
ATOM   2661 S  SD  . MET B 2 30  ? -28.128 12.572  5.773   1    58.13  ? 200 MET B SD  1 
ATOM   2662 C  CE  . MET B 2 30  ? -27.272 11.697  4.46    1    59.34  ? 200 MET B CE  1 
ATOM   2663 N  N   . LYS B 2 31  ? -33.214 12.666  7.368   1    58.35  ? 201 LYS B N   1 
ATOM   2664 C  CA  . LYS B 2 31  ? -34.198 13.587  7.978   1    63.87  ? 201 LYS B CA  1 
ATOM   2665 C  C   . LYS B 2 31  ? -33.89  13.727  9.47    1    65.79  ? 201 LYS B C   1 
ATOM   2666 O  O   . LYS B 2 31  ? -34.042 14.839  10      1    73.82  ? 201 LYS B O   1 
ATOM   2667 C  CB  . LYS B 2 31  ? -35.606 13.035  7.759   1    71.32  ? 201 LYS B CB  1 
ATOM   2668 C  CG  . LYS B 2 31  ? -36.075 13.018  6.317   1    86.94  ? 201 LYS B CG  1 
ATOM   2669 C  CD  . LYS B 2 31  ? -37.474 12.434  6.172   1    109.11 ? 201 LYS B CD  1 
ATOM   2670 C  CE  . LYS B 2 31  ? -37.955 12.434  4.757   1    117.24 ? 201 LYS B CE  1 
ATOM   2671 N  NZ  . LYS B 2 31  ? -39.292 11.847  4.636   1    114.81 ? 201 LYS B NZ  1 
ATOM   2672 N  N   . LYS B 2 32  ? -33.462 12.643  10.111  1    71.38  ? 202 LYS B N   1 
ATOM   2673 C  CA  . LYS B 2 32  ? -33.164 12.676  11.564  1    75.08  ? 202 LYS B CA  1 
ATOM   2674 C  C   . LYS B 2 32  ? -31.741 13.194  11.792  1    68.67  ? 202 LYS B C   1 
ATOM   2675 O  O   . LYS B 2 32  ? -31.357 13.331  12.962  1    65.08  ? 202 LYS B O   1 
ATOM   2676 C  CB  . LYS B 2 32  ? -33.37  11.288  12.173  1    77.04  ? 202 LYS B CB  1 
ATOM   2677 C  CG  . LYS B 2 32  ? -34.808 10.812  12.182  1    87.48  ? 202 LYS B CG  1 
ATOM   2678 C  CD  . LYS B 2 32  ? -34.971 9.418   12.772  1    96.06  ? 202 LYS B CD  1 
ATOM   2679 C  CE  . LYS B 2 32  ? -36.4   8.987   12.789  1    105.52 ? 202 LYS B CE  1 
ATOM   2680 N  NZ  . LYS B 2 32  ? -36.549 7.636   13.337  1    114.75 ? 202 LYS B NZ  1 
ATOM   2681 N  N   . GLN B 2 33  ? -30.989 13.456  10.725  1    57.86  ? 203 GLN B N   1 
ATOM   2682 C  CA  . GLN B 2 33  ? -29.672 14.05   10.912  1    54.39  ? 203 GLN B CA  1 
ATOM   2683 C  C   . GLN B 2 33  ? -29.796 15.568  10.83   1    52.97  ? 203 GLN B C   1 
ATOM   2684 O  O   . GLN B 2 33  ? -30.155 16.102  9.794   1    56.4   ? 203 GLN B O   1 
ATOM   2685 C  CB  . GLN B 2 33  ? -28.702 13.537  9.845   1    50.82  ? 203 GLN B CB  1 
ATOM   2686 C  CG  . GLN B 2 33  ? -28.211 12.112  10.078  1    48.71  ? 203 GLN B CG  1 
ATOM   2687 C  CD  . GLN B 2 33  ? -27.083 12.001  11.079  1    46.93  ? 203 GLN B CD  1 
ATOM   2688 O  OE1 . GLN B 2 33  ? -26.498 12.988  11.529  1    47.6   ? 203 GLN B OE1 1 
ATOM   2689 N  NE2 . GLN B 2 33  ? -26.762 10.772  11.446  1    46.39  ? 203 GLN B NE2 1 
ATOM   2690 N  N   . PRO B 2 34  ? -29.607 16.323  11.929  1    56.1   ? 204 PRO B N   1 
ATOM   2691 C  CA  . PRO B 2 34  ? -29.92  17.758  11.914  1    57.24  ? 204 PRO B CA  1 
ATOM   2692 C  C   . PRO B 2 34  ? -29.014 18.556  10.986  1    57.97  ? 204 PRO B C   1 
ATOM   2693 O  O   . PRO B 2 34  ? -29.47  19.517  10.395  1    61.14  ? 204 PRO B O   1 
ATOM   2694 C  CB  . PRO B 2 34  ? -29.781 18.193  13.381  1    54.16  ? 204 PRO B CB  1 
ATOM   2695 C  CG  . PRO B 2 34  ? -28.851 17.135  13.978  1    52.65  ? 204 PRO B CG  1 
ATOM   2696 C  CD  . PRO B 2 34  ? -29.203 15.849  13.266  1    52.79  ? 204 PRO B CD  1 
ATOM   2697 N  N   . ASP B 2 35  ? -27.744 18.139  10.856  1    58.75  ? 205 ASP B N   1 
ATOM   2698 C  CA  . ASP B 2 35  ? -26.711 19.006  10.314  1    57.74  ? 205 ASP B CA  1 
ATOM   2699 C  C   . ASP B 2 35  ? -26.052 18.464  9.046   1    60.36  ? 205 ASP B C   1 
ATOM   2700 O  O   . ASP B 2 35  ? -25.144 19.109  8.523   1    65.21  ? 205 ASP B O   1 
ATOM   2701 C  CB  . ASP B 2 35  ? -25.625 19.27   11.328  1    56.28  ? 205 ASP B CB  1 
ATOM   2702 C  CG  . ASP B 2 35  ? -24.717 20.421  10.949  1    62.83  ? 205 ASP B CG  1 
ATOM   2703 O  OD1 . ASP B 2 35  ? -25.263 21.461  10.506  1    64.45  ? 205 ASP B OD1 1 
ATOM   2704 O  OD2 . ASP B 2 35  ? -23.481 20.265  11.098  1    66     ? 205 ASP B OD2 1 
ATOM   2705 N  N   . ILE B 2 36  ? -26.502 17.304  8.549   1    58.93  ? 206 ILE B N   1 
ATOM   2706 C  CA  . ILE B 2 36  ? -25.982 16.726  7.317   1    59.69  ? 206 ILE B CA  1 
ATOM   2707 C  C   . ILE B 2 36  ? -27.141 16.317  6.397   1    62.41  ? 206 ILE B C   1 
ATOM   2708 O  O   . ILE B 2 36  ? -28.256 16.02   6.854   1    55.75  ? 206 ILE B O   1 
ATOM   2709 C  CB  . ILE B 2 36  ? -24.986 15.572  7.584   1    57.67  ? 206 ILE B CB  1 
ATOM   2710 C  CG1 . ILE B 2 36  ? -25.644 14.326  8.127   1    57.24  ? 206 ILE B CG1 1 
ATOM   2711 C  CG2 . ILE B 2 36  ? -23.832 16.008  8.491   1    59.77  ? 206 ILE B CG2 1 
ATOM   2712 C  CD1 . ILE B 2 36  ? -24.667 13.201  8.39    1    60.8   ? 206 ILE B CD1 1 
ATOM   2713 N  N   . THR B 2 37  ? -26.837 16.288  5.08    1    58.68  ? 207 THR B N   1 
ATOM   2714 C  CA  . THR B 2 37  ? -27.81  16.113  4.011   1    54.56  ? 207 THR B CA  1 
ATOM   2715 C  C   . THR B 2 37  ? -27.335 15.024  3.062   1    51.21  ? 207 THR B C   1 
ATOM   2716 O  O   . THR B 2 37  ? -26.144 14.712  3.037   1    54.21  ? 207 THR B O   1 
ATOM   2717 C  CB  . THR B 2 37  ? -27.954 17.414  3.22    1    55.51  ? 207 THR B CB  1 
ATOM   2718 O  OG1 . THR B 2 37  ? -26.674 17.649  2.635   1    55.16  ? 207 THR B OG1 1 
ATOM   2719 C  CG2 . THR B 2 37  ? -28.402 18.597  4.052   1    50.28  ? 207 THR B CG2 1 
ATOM   2720 N  N   . ASN B 2 38  ? -28.269 14.508  2.248   1    49.18  ? 208 ASN B N   1 
ATOM   2721 C  CA  . ASN B 2 38  ? -27.96  13.603  1.147   1    50.36  ? 208 ASN B CA  1 
ATOM   2722 C  C   . ASN B 2 38  ? -26.837 14.171  0.275   1    50.19  ? 208 ASN B C   1 
ATOM   2723 O  O   . ASN B 2 38  ? -25.929 13.438  -0.118  1    47.42  ? 208 ASN B O   1 
ATOM   2724 C  CB  . ASN B 2 38  ? -29.178 13.276  0.295   1    51.11  ? 208 ASN B CB  1 
ATOM   2725 C  CG  . ASN B 2 38  ? -30.216 12.522  1.098   1    54.39  ? 208 ASN B CG  1 
ATOM   2726 O  OD1 . ASN B 2 38  ? -29.872 11.69   1.939   1    54.65  ? 208 ASN B OD1 1 
ATOM   2727 N  ND2 . ASN B 2 38  ? -31.484 12.81   0.877   1    55.3   ? 208 ASN B ND2 1 
ATOM   2728 N  N   . SER B 2 39  ? -26.869 15.489  0.059   1    49.41  ? 209 SER B N   1 
ATOM   2729 C  CA  . SER B 2 39  ? -25.881 16.16   -0.766  1    53.38  ? 209 SER B CA  1 
ATOM   2730 C  C   . SER B 2 39  ? -24.482 16.074  -0.149  1    52.72  ? 209 SER B C   1 
ATOM   2731 O  O   . SER B 2 39  ? -23.506 15.881  -0.86   1    57.61  ? 209 SER B O   1 
ATOM   2732 C  CB  . SER B 2 39  ? -26.314 17.564  -1.05   1    56.02  ? 209 SER B CB  1 
ATOM   2733 O  OG  . SER B 2 39  ? -25.322 18.225  -1.817  1    64.72  ? 209 SER B OG  1 
ATOM   2734 N  N   . MET B 2 40  ? -24.371 16.19   1.174   1    52.82  ? 210 MET B N   1 
ATOM   2735 C  CA  . MET B 2 40  ? -23.07  16.098  1.828   1    53.27  ? 210 MET B CA  1 
ATOM   2736 C  C   . MET B 2 40  ? -22.534 14.676  1.771   1    52.59  ? 210 MET B C   1 
ATOM   2737 O  O   . MET B 2 40  ? -21.327 14.484  1.61    1    54.71  ? 210 MET B O   1 
ATOM   2738 C  CB  . MET B 2 40  ? -23.143 16.545  3.288   1    52.88  ? 210 MET B CB  1 
ATOM   2739 C  CG  . MET B 2 40  ? -23.5   18.016  3.434   1    56.55  ? 210 MET B CG  1 
ATOM   2740 S  SD  . MET B 2 40  ? -23.558 18.494  5.167   1    57.14  ? 210 MET B SD  1 
ATOM   2741 C  CE  . MET B 2 40  ? -24.52  20.007  5.014   1    54.83  ? 210 MET B CE  1 
ATOM   2742 N  N   . ARG B 2 41  ? -23.438 13.692  1.929   1    48.84  ? 211 ARG B N   1 
ATOM   2743 C  CA  . ARG B 2 41  ? -23.074 12.283  1.862   1    42.86  ? 211 ARG B CA  1 
ATOM   2744 C  C   . ARG B 2 41  ? -22.57  11.961  0.46    1    43.76  ? 211 ARG B C   1 
ATOM   2745 O  O   . ARG B 2 41  ? -21.636 11.181  0.308   1    42.99  ? 211 ARG B O   1 
ATOM   2746 C  CB  . ARG B 2 41  ? -24.295 11.428  2.177   1    43.41  ? 211 ARG B CB  1 
ATOM   2747 C  CG  . ARG B 2 41  ? -24.049 9.923   2.161   1    43.56  ? 211 ARG B CG  1 
ATOM   2748 C  CD  . ARG B 2 41  ? -25.402 9.207   2.261   1    47.01  ? 211 ARG B CD  1 
ATOM   2749 N  NE  . ARG B 2 41  ? -25.248 7.788   1.94    1    46.82  ? 211 ARG B NE  1 
ATOM   2750 C  CZ  . ARG B 2 41  ? -24.967 7.315   0.741   1    42.43  ? 211 ARG B CZ  1 
ATOM   2751 N  NH1 . ARG B 2 41  ? -25.008 8.121   -0.305  1    40.7   ? 211 ARG B NH1 1 
ATOM   2752 N  NH2 . ARG B 2 41  ? -24.671 6.034   0.6     1    38.23  ? 211 ARG B NH2 1 
ATOM   2753 N  N   . ALA B 2 42  ? -23.179 12.598  -0.559  1    44.39  ? 212 ALA B N   1 
ATOM   2754 C  CA  . ALA B 2 42  ? -22.769 12.425  -1.942  1    41.69  ? 212 ALA B CA  1 
ATOM   2755 C  C   . ALA B 2 42  ? -21.311 12.874  -2.112  1    43.33  ? 212 ALA B C   1 
ATOM   2756 O  O   . ALA B 2 42  ? -20.48  12.189  -2.693  1    43.22  ? 212 ALA B O   1 
ATOM   2757 C  CB  . ALA B 2 42  ? -23.705 13.213  -2.816  1    39.73  ? 212 ALA B CB  1 
ATOM   2758 N  N   . ILE B 2 43  ? -20.993 14.053  -1.594  1    45.01  ? 213 ILE B N   1 
ATOM   2759 C  CA  . ILE B 2 43  ? -19.638 14.567  -1.593  1    44.75  ? 213 ILE B CA  1 
ATOM   2760 C  C   . ILE B 2 43  ? -18.68  13.576  -0.909  1    45.31  ? 213 ILE B C   1 
ATOM   2761 O  O   . ILE B 2 43  ? -17.601 13.293  -1.416  1    47.02  ? 213 ILE B O   1 
ATOM   2762 C  CB  . ILE B 2 43  ? -19.678 15.966  -0.959  1    44.87  ? 213 ILE B CB  1 
ATOM   2763 C  CG1 . ILE B 2 43  ? -20.456 16.949  -1.866  1    45.75  ? 213 ILE B CG1 1 
ATOM   2764 C  CG2 . ILE B 2 43  ? -18.279 16.476  -0.626  1    45.21  ? 213 ILE B CG2 1 
ATOM   2765 C  CD1 . ILE B 2 43  ? -20.69  18.327  -1.267  1    44.38  ? 213 ILE B CD1 1 
ATOM   2766 N  N   . LEU B 2 44  ? -19.083 13.009  0.225   1    45.9   ? 214 LEU B N   1 
ATOM   2767 C  CA  . LEU B 2 44  ? -18.224 12.11   0.977   1    47.51  ? 214 LEU B CA  1 
ATOM   2768 C  C   . LEU B 2 44  ? -17.918 10.837  0.183   1    50.59  ? 214 LEU B C   1 
ATOM   2769 O  O   . LEU B 2 44  ? -16.755 10.4    0.081   1    47.26  ? 214 LEU B O   1 
ATOM   2770 C  CB  . LEU B 2 44  ? -18.873 11.779  2.313   1    40.94  ? 214 LEU B CB  1 
ATOM   2771 C  CG  . LEU B 2 44  ? -18.135 10.753  3.177   1    39.23  ? 214 LEU B CG  1 
ATOM   2772 C  CD1 . LEU B 2 44  ? -16.843 11.312  3.676   1    38.29  ? 214 LEU B CD1 1 
ATOM   2773 C  CD2 . LEU B 2 44  ? -18.987 10.298  4.361   1    37.24  ? 214 LEU B CD2 1 
ATOM   2774 N  N   . VAL B 2 45  ? -18.987 10.237  -0.347  1    44.34  ? 215 VAL B N   1 
ATOM   2775 C  CA  . VAL B 2 45  ? -18.854 8.995   -1.091  1    43.84  ? 215 VAL B CA  1 
ATOM   2776 C  C   . VAL B 2 45  ? -18.018 9.227   -2.355  1    45.53  ? 215 VAL B C   1 
ATOM   2777 O  O   . VAL B 2 45  ? -17.165 8.398   -2.679  1    44.87  ? 215 VAL B O   1 
ATOM   2778 C  CB  . VAL B 2 45  ? -20.25  8.396   -1.361  1    44.25  ? 215 VAL B CB  1 
ATOM   2779 C  CG1 . VAL B 2 45  ? -20.178 7.181   -2.283  1    45.6   ? 215 VAL B CG1 1 
ATOM   2780 C  CG2 . VAL B 2 45  ? -21.001 8.065   -0.052  1    39.13  ? 215 VAL B CG2 1 
ATOM   2781 N  N   . ASP B 2 46  ? -18.221 10.374  -3.031  1    42.53  ? 216 ASP B N   1 
ATOM   2782 C  CA  . ASP B 2 46  ? -17.501 10.685  -4.248  1    43.96  ? 216 ASP B CA  1 
ATOM   2783 C  C   . ASP B 2 46  ? -16.021 10.807  -3.918  1    46.15  ? 216 ASP B C   1 
ATOM   2784 O  O   . ASP B 2 46  ? -15.163 10.362  -4.692  1    48.47  ? 216 ASP B O   1 
ATOM   2785 C  CB  . ASP B 2 46  ? -18.019 11.953  -4.898  1    46.65  ? 216 ASP B CB  1 
ATOM   2786 C  CG  . ASP B 2 46  ? -17.26  12.4    -6.14   1    48.78  ? 216 ASP B CG  1 
ATOM   2787 O  OD1 . ASP B 2 46  ? -17.536 11.874  -7.234  1    54.69  ? 216 ASP B OD1 1 
ATOM   2788 O  OD2 . ASP B 2 46  ? -16.37  13.244  -6.006  1    52.99  ? 216 ASP B OD2 1 
ATOM   2789 N  N   . TRP B 2 47  ? -15.742 11.398  -2.753  1    42.95  ? 217 TRP B N   1 
ATOM   2790 C  CA  . TRP B 2 47  ? -14.374 11.524  -2.28   1    46.05  ? 217 TRP B CA  1 
ATOM   2791 C  C   . TRP B 2 47  ? -13.764 10.14   -2.077  1    45.8   ? 217 TRP B C   1 
ATOM   2792 O  O   . TRP B 2 47  ? -12.632 9.893   -2.506  1    46.35  ? 217 TRP B O   1 
ATOM   2793 C  CB  . TRP B 2 47  ? -14.314 12.375  -1.005  1    44.06  ? 217 TRP B CB  1 
ATOM   2794 C  CG  . TRP B 2 47  ? -12.964 12.475  -0.344  1    42.25  ? 217 TRP B CG  1 
ATOM   2795 C  CD1 . TRP B 2 47  ? -11.865 13.124  -0.82   1    42.25  ? 217 TRP B CD1 1 
ATOM   2796 C  CD2 . TRP B 2 47  ? -12.591 11.935  0.944   1    40.28  ? 217 TRP B CD2 1 
ATOM   2797 N  NE1 . TRP B 2 47  ? -10.828 13.018  0.068   1    43.18  ? 217 TRP B NE1 1 
ATOM   2798 C  CE2 . TRP B 2 47  ? -11.252 12.309  1.169   1    44.05  ? 217 TRP B CE2 1 
ATOM   2799 C  CE3 . TRP B 2 47  ? -13.249 11.182  1.915   1    40.47  ? 217 TRP B CE3 1 
ATOM   2800 C  CZ2 . TRP B 2 47  ? -10.567 11.948  2.326   1    44.65  ? 217 TRP B CZ2 1 
ATOM   2801 C  CZ3 . TRP B 2 47  ? -12.581 10.811  3.06    1    41.66  ? 217 TRP B CZ3 1 
ATOM   2802 C  CH2 . TRP B 2 47  ? -11.251 11.191  3.251   1    46.75  ? 217 TRP B CH2 1 
ATOM   2803 N  N   . LEU B 2 48  ? -14.536 9.25    -1.454  1    44.86  ? 218 LEU B N   1 
ATOM   2804 C  CA  . LEU B 2 48  ? -14.077 7.903   -1.125  1    45.78  ? 218 LEU B CA  1 
ATOM   2805 C  C   . LEU B 2 48  ? -13.776 7.143   -2.407  1    42.65  ? 218 LEU B C   1 
ATOM   2806 O  O   . LEU B 2 48  ? -12.848 6.353   -2.422  1    43.16  ? 218 LEU B O   1 
ATOM   2807 C  CB  . LEU B 2 48  ? -15.085 7.148   -0.254  1    41.91  ? 218 LEU B CB  1 
ATOM   2808 C  CG  . LEU B 2 48  ? -15.259 7.699   1.172   1    40.07  ? 218 LEU B CG  1 
ATOM   2809 C  CD1 . LEU B 2 48  ? -16.339 6.944   1.914   1    36.1   ? 218 LEU B CD1 1 
ATOM   2810 C  CD2 . LEU B 2 48  ? -13.945 7.56    1.917   1    40.52  ? 218 LEU B CD2 1 
ATOM   2811 N  N   . VAL B 2 49  ? -14.543 7.411   -3.467  1    40.05  ? 219 VAL B N   1 
ATOM   2812 C  CA  . VAL B 2 49  ? -14.246 6.857   -4.774  1    39.59  ? 219 VAL B CA  1 
ATOM   2813 C  C   . VAL B 2 49  ? -12.839 7.279   -5.191  1    42.15  ? 219 VAL B C   1 
ATOM   2814 O  O   . VAL B 2 49  ? -12.056 6.442   -5.619  1    42.17  ? 219 VAL B O   1 
ATOM   2815 C  CB  . VAL B 2 49  ? -15.303 7.259   -5.812  1    39.17  ? 219 VAL B CB  1 
ATOM   2816 C  CG1 . VAL B 2 49  ? -14.913 6.842   -7.225  1    37.55  ? 219 VAL B CG1 1 
ATOM   2817 C  CG2 . VAL B 2 49  ? -16.656 6.665   -5.439  1    39.37  ? 219 VAL B CG2 1 
ATOM   2818 N  N   . GLU B 2 50  ? -12.517 8.571   -5.052  1    45.71  ? 220 GLU B N   1 
ATOM   2819 C  CA  . GLU B 2 50  ? -11.195 9.075   -5.379  1    46.76  ? 220 GLU B CA  1 
ATOM   2820 C  C   . GLU B 2 50  ? -10.122 8.495   -4.46   1    47.96  ? 220 GLU B C   1 
ATOM   2821 O  O   . GLU B 2 50  ? -9.049  8.138   -4.911  1    51.4   ? 220 GLU B O   1 
ATOM   2822 C  CB  . GLU B 2 50  ? -11.129 10.579  -5.172  1    51.24  ? 220 GLU B CB  1 
ATOM   2823 C  CG  . GLU B 2 50  ? -11.878 11.353  -6.242  1    57.86  ? 220 GLU B CG  1 
ATOM   2824 C  CD  . GLU B 2 50  ? -11.515 12.82   -6.158  1    65.17  ? 220 GLU B CD  1 
ATOM   2825 O  OE1 . GLU B 2 50  ? -11.313 13.408  -7.247  1    70.76  ? 220 GLU B OE1 1 
ATOM   2826 O  OE2 . GLU B 2 50  ? -11.4   13.342  -5.01   1    67.77  ? 220 GLU B OE2 1 
ATOM   2827 N  N   . VAL B 2 51  ? -10.386 8.414   -3.166  1    49.08  ? 221 VAL B N   1 
ATOM   2828 C  CA  . VAL B 2 51  ? -9.393  7.791   -2.237  1    46.23  ? 221 VAL B CA  1 
ATOM   2829 C  C   . VAL B 2 51  ? -9.065  6.366   -2.707  1    44.28  ? 221 VAL B C   1 
ATOM   2830 O  O   . VAL B 2 51  ? -7.877  6.015   -2.747  1    47.86  ? 221 VAL B O   1 
ATOM   2831 C  CB  . VAL B 2 51  ? -9.904  7.812   -0.786  1    44.06  ? 221 VAL B CB  1 
ATOM   2832 C  CG1 . VAL B 2 51  ? -9.033  6.984   0.148   1    38.49  ? 221 VAL B CG1 1 
ATOM   2833 C  CG2 . VAL B 2 51  ? -10.083 9.232   -0.272  1    43.68  ? 221 VAL B CG2 1 
ATOM   2834 N  N   . GLY B 2 52  ? -10.081 5.596   -3.079  1    42.36  ? 222 GLY B N   1 
ATOM   2835 C  CA  . GLY B 2 52  ? -9.873  4.2     -3.49   1    45.11  ? 222 GLY B CA  1 
ATOM   2836 C  C   . GLY B 2 52  ? -9.042  4.071   -4.744  1    50.42  ? 222 GLY B C   1 
ATOM   2837 O  O   . GLY B 2 52  ? -8.276  3.106   -4.843  1    52.99  ? 222 GLY B O   1 
ATOM   2838 N  N   . GLU B 2 53  ? -9.19   5.005   -5.673  1    51.62  ? 223 GLU B N   1 
ATOM   2839 C  CA  . GLU B 2 53  ? -8.445  4.941   -6.952  1    56.25  ? 223 GLU B CA  1 
ATOM   2840 C  C   . GLU B 2 53  ? -7.004  5.409   -6.727  1    55.88  ? 223 GLU B C   1 
ATOM   2841 O  O   . GLU B 2 53  ? -6.108  4.898   -7.41   1    66.48  ? 223 GLU B O   1 
ATOM   2842 C  CB  . GLU B 2 53  ? -9.2    5.75    -8      1    56.74  ? 223 GLU B CB  1 
ATOM   2843 C  CG  . GLU B 2 53  ? -10.27  4.926   -8.705  1    74.02  ? 223 GLU B CG  1 
ATOM   2844 C  CD  . GLU B 2 53  ? -9.892  3.481   -8.981  1    94.99  ? 223 GLU B CD  1 
ATOM   2845 O  OE1 . GLU B 2 53  ? -9.238  3.241   -10.013 1    82.71  ? 223 GLU B OE1 1 
ATOM   2846 O  OE2 . GLU B 2 53  ? -10.254 2.593   -8.181  1    94.66  ? 223 GLU B OE2 1 
ATOM   2847 N  N   . GLU B 2 54  ? -6.803  6.325   -5.79   1    54.52  ? 224 GLU B N   1 
ATOM   2848 C  CA  . GLU B 2 54  ? -5.442  6.817   -5.477  1    57.88  ? 224 GLU B CA  1 
ATOM   2849 C  C   . GLU B 2 54  ? -4.656  5.71    -4.766  1    53.31  ? 224 GLU B C   1 
ATOM   2850 O  O   . GLU B 2 54  ? -3.447  5.597   -5.011  1    52.42  ? 224 GLU B O   1 
ATOM   2851 C  CB  . GLU B 2 54  ? -5.561  8.08    -4.628  1    66.38  ? 224 GLU B CB  1 
ATOM   2852 C  CG  . GLU B 2 54  ? -4.263  8.496   -3.945  1    73.49  ? 224 GLU B CG  1 
ATOM   2853 C  CD  . GLU B 2 54  ? -3.295  9.2     -4.874  1    83.4   ? 224 GLU B CD  1 
ATOM   2854 O  OE1 . GLU B 2 54  ? -3.759  10.006  -5.705  1    87.95  ? 224 GLU B OE1 1 
ATOM   2855 O  OE2 . GLU B 2 54  ? -2.08   8.942   -4.766  1    88.05  ? 224 GLU B OE2 1 
ATOM   2856 N  N   . TYR B 2 55  ? -5.324  4.917   -3.935  1    46.88  ? 225 TYR B N   1 
ATOM   2857 C  CA  . TYR B 2 55  ? -4.61   3.87    -3.162  1    49.17  ? 225 TYR B CA  1 
ATOM   2858 C  C   . TYR B 2 55  ? -4.816  2.539   -3.849  1    50.46  ? 225 TYR B C   1 
ATOM   2859 O  O   . TYR B 2 55  ? -4.293  1.534   -3.353  1    53.11  ? 225 TYR B O   1 
ATOM   2860 C  CB  . TYR B 2 55  ? -5.046  3.969   -1.699  1    48.86  ? 225 TYR B CB  1 
ATOM   2861 C  CG  . TYR B 2 55  ? -4.364  5.131   -0.998  1    56.06  ? 225 TYR B CG  1 
ATOM   2862 C  CD1 . TYR B 2 55  ? -4.944  6.39    -0.974  1    62.72  ? 225 TYR B CD1 1 
ATOM   2863 C  CD2 . TYR B 2 55  ? -3.123  4.974   -0.399  1    58.83  ? 225 TYR B CD2 1 
ATOM   2864 C  CE1 . TYR B 2 55  ? -4.317  7.455   -0.355  1    62.29  ? 225 TYR B CE1 1 
ATOM   2865 C  CE2 . TYR B 2 55  ? -2.489  6.032   0.227   1    64.47  ? 225 TYR B CE2 1 
ATOM   2866 C  CZ  . TYR B 2 55  ? -3.089  7.276   0.251   1    63.73  ? 225 TYR B CZ  1 
ATOM   2867 O  OH  . TYR B 2 55  ? -2.47   8.325   0.862   1    70.1   ? 225 TYR B OH  1 
ATOM   2868 N  N   . LYS B 2 56  ? -5.55   2.537   -4.958  1    50.91  ? 226 LYS B N   1 
ATOM   2869 C  CA  . LYS B 2 56  ? -5.727  1.323   -5.75   1    53.39  ? 226 LYS B CA  1 
ATOM   2870 C  C   . LYS B 2 56  ? -6.407  0.245   -4.895  1    50.44  ? 226 LYS B C   1 
ATOM   2871 O  O   . LYS B 2 56  ? -5.995  -0.913  -4.865  1    51.61  ? 226 LYS B O   1 
ATOM   2872 C  CB  . LYS B 2 56  ? -4.472  0.904   -6.543  1    54.68  ? 226 LYS B CB  1 
ATOM   2873 C  CG  . LYS B 2 56  ? -3.916  2.067   -7.342  1    67.46  ? 226 LYS B CG  1 
ATOM   2874 C  CD  . LYS B 2 56  ? -3.521  1.863   -8.804  1    84.58  ? 226 LYS B CD  1 
ATOM   2875 C  CE  . LYS B 2 56  ? -2.364  0.963   -9.116  1    93.34  ? 226 LYS B CE  1 
ATOM   2876 N  NZ  . LYS B 2 56  ? -1.235  1.33    -8.261  1    94.37  ? 226 LYS B NZ  1 
ATOM   2877 N  N   . LEU B 2 57  ? -7.463  0.65    -4.188  1    47.73  ? 227 LEU B N   1 
ATOM   2878 C  CA  . LEU B 2 57  ? -8.238  -0.259  -3.365  1    45.8   ? 227 LEU B CA  1 
ATOM   2879 C  C   . LEU B 2 57  ? -9.215  -1.007  -4.251  1    44.02  ? 227 LEU B C   1 
ATOM   2880 O  O   . LEU B 2 57  ? -9.626  -0.496  -5.289  1    47.9   ? 227 LEU B O   1 
ATOM   2881 C  CB  . LEU B 2 57  ? -8.997  0.546   -2.314  1    42.97  ? 227 LEU B CB  1 
ATOM   2882 C  CG  . LEU B 2 57  ? -8.104  1.395   -1.413  1    44.34  ? 227 LEU B CG  1 
ATOM   2883 C  CD1 . LEU B 2 57  ? -8.947  2.105   -0.363  1    40.42  ? 227 LEU B CD1 1 
ATOM   2884 C  CD2 . LEU B 2 57  ? -7.02   0.537   -0.774  1    38.38  ? 227 LEU B CD2 1 
ATOM   2885 N  N   . GLN B 2 58  ? -9.614  -2.187  -3.783  1    40.38  ? 228 GLN B N   1 
ATOM   2886 C  CA  . GLN B 2 58  ? -10.698 -2.935  -4.382  1    37.79  ? 228 GLN B CA  1 
ATOM   2887 C  C   . GLN B 2 58  ? -11.969 -2.1    -4.331  1    41.21  ? 228 GLN B C   1 
ATOM   2888 O  O   . GLN B 2 58  ? -12.176 -1.273  -3.426  1    44.26  ? 228 GLN B O   1 
ATOM   2889 C  CB  . GLN B 2 58  ? -10.922 -4.19   -3.535  1    39.38  ? 228 GLN B CB  1 
ATOM   2890 C  CG  . GLN B 2 58  ? -9.779  -5.192  -3.542  1    44.16  ? 228 GLN B CG  1 
ATOM   2891 C  CD  . GLN B 2 58  ? -9.42   -5.541  -4.969  1    45.32  ? 228 GLN B CD  1 
ATOM   2892 O  OE1 . GLN B 2 58  ? -10.273 -5.964  -5.748  1    46.47  ? 228 GLN B OE1 1 
ATOM   2893 N  NE2 . GLN B 2 58  ? -8.171  -5.299  -5.331  1    45.36  ? 228 GLN B NE2 1 
ATOM   2894 N  N   . ASN B 2 59  ? -12.86  -2.381  -5.28   1    44.12  ? 229 ASN B N   1 
ATOM   2895 C  CA  . ASN B 2 59  ? -14.193 -1.796  -5.259  1    41.5   ? 229 ASN B CA  1 
ATOM   2896 C  C   . ASN B 2 59  ? -14.98  -2.319  -4.062  1    40.96  ? 229 ASN B C   1 
ATOM   2897 O  O   . ASN B 2 59  ? -15.834 -1.601  -3.535  1    45.66  ? 229 ASN B O   1 
ATOM   2898 C  CB  . ASN B 2 59  ? -14.914 -1.998  -6.586  1    40.47  ? 229 ASN B CB  1 
ATOM   2899 C  CG  . ASN B 2 59  ? -14.261 -1.196  -7.686  1    43.86  ? 229 ASN B CG  1 
ATOM   2900 O  OD1 . ASN B 2 59  ? -13.527 -0.222  -7.443  1    43.18  ? 229 ASN B OD1 1 
ATOM   2901 N  ND2 . ASN B 2 59  ? -14.518 -1.599  -8.912  1    46.6   ? 229 ASN B ND2 1 
ATOM   2902 N  N   . GLU B 2 60  ? -14.729 -3.582  -3.681  1    38.37  ? 230 GLU B N   1 
ATOM   2903 C  CA  . GLU B 2 60  ? -15.476 -4.194  -2.593  1    35.24  ? 230 GLU B CA  1 
ATOM   2904 C  C   . GLU B 2 60  ? -15.254 -3.351  -1.331  1    36.18  ? 230 GLU B C   1 
ATOM   2905 O  O   . GLU B 2 60  ? -16.17  -3.17   -0.523  1    33.26  ? 230 GLU B O   1 
ATOM   2906 C  CB  . GLU B 2 60  ? -15.074 -5.663  -2.448  1    32.74  ? 230 GLU B CB  1 
ATOM   2907 C  CG  . GLU B 2 60  ? -15.607 -6.37   -1.205  1    29.78  ? 230 GLU B CG  1 
ATOM   2908 C  CD  . GLU B 2 60  ? -17.116 -6.538  -1.208  1    35.35  ? 230 GLU B CD  1 
ATOM   2909 O  OE1 . GLU B 2 60  ? -17.724 -6.36   -2.282  1    35.04  ? 230 GLU B OE1 1 
ATOM   2910 O  OE2 . GLU B 2 60  ? -17.687 -6.874  -0.132  1    38.01  ? 230 GLU B OE2 1 
ATOM   2911 N  N   . THR B 2 61  ? -14.048 -2.78   -1.22   1    36.47  ? 231 THR B N   1 
ATOM   2912 C  CA  . THR B 2 61  ? -13.655 -2.005  -0.052  1    41.73  ? 231 THR B CA  1 
ATOM   2913 C  C   . THR B 2 61  ? -14.488 -0.726  0.034   1    43.03  ? 231 THR B C   1 
ATOM   2914 O  O   . THR B 2 61  ? -14.923 -0.35   1.127   1    38.96  ? 231 THR B O   1 
ATOM   2915 C  CB  . THR B 2 61  ? -12.16  -1.687  -0.092  1    40.74  ? 231 THR B CB  1 
ATOM   2916 O  OG1 . THR B 2 61  ? -11.46  -2.918  -0.22   1    39.66  ? 231 THR B OG1 1 
ATOM   2917 C  CG2 . THR B 2 61  ? -11.702 -1.035  1.195   1    42.28  ? 231 THR B CG2 1 
ATOM   2918 N  N   . LEU B 2 62  ? -14.662 -0.075  -1.129  1    40.69  ? 232 LEU B N   1 
ATOM   2919 C  CA  . LEU B 2 62  ? -15.489 1.106   -1.28   1    40.97  ? 232 LEU B CA  1 
ATOM   2920 C  C   . LEU B 2 62  ? -16.907 0.791   -0.826  1    36.83  ? 232 LEU B C   1 
ATOM   2921 O  O   . LEU B 2 62  ? -17.463 1.542   -0.038  1    36.09  ? 232 LEU B O   1 
ATOM   2922 C  CB  . LEU B 2 62  ? -15.467 1.61    -2.73   1    44.7   ? 232 LEU B CB  1 
ATOM   2923 C  CG  . LEU B 2 62  ? -16.455 2.742   -3.069  1    39.39  ? 232 LEU B CG  1 
ATOM   2924 C  CD1 . LEU B 2 62  ? -16.037 4.022   -2.367  1    36.01  ? 232 LEU B CD1 1 
ATOM   2925 C  CD2 . LEU B 2 62  ? -16.601 2.958   -4.571  1    35.83  ? 232 LEU B CD2 1 
ATOM   2926 N  N   . HIS B 2 63  ? -17.473 -0.315  -1.325  1    35.59  ? 233 HIS B N   1 
ATOM   2927 C  CA  . HIS B 2 63  ? -18.85  -0.668  -0.991  1    33.22  ? 233 HIS B CA  1 
ATOM   2928 C  C   . HIS B 2 63  ? -18.998 -0.947  0.506   1    37.09  ? 233 HIS B C   1 
ATOM   2929 O  O   . HIS B 2 63  ? -20.027 -0.636  1.083   1    37.29  ? 233 HIS B O   1 
ATOM   2930 C  CB  . HIS B 2 63  ? -19.345 -1.856  -1.817  1    32.26  ? 233 HIS B CB  1 
ATOM   2931 C  CG  . HIS B 2 63  ? -19.743 -1.563  -3.22   1    36.54  ? 233 HIS B CG  1 
ATOM   2932 N  ND1 . HIS B 2 63  ? -18.821 -1.323  -4.243  1    38.06  ? 233 HIS B ND1 1 
ATOM   2933 C  CD2 . HIS B 2 63  ? -20.983 -1.456  -3.759  1    30.16  ? 233 HIS B CD2 1 
ATOM   2934 C  CE1 . HIS B 2 63  ? -19.497 -1.058  -5.363  1    34.77  ? 233 HIS B CE1 1 
ATOM   2935 N  NE2 . HIS B 2 63  ? -20.81  -1.134  -5.082  1    34.18  ? 233 HIS B NE2 1 
ATOM   2936 N  N   . LEU B 2 64  ? -18.002 -1.605  1.12    1    35.7   ? 234 LEU B N   1 
ATOM   2937 C  CA  . LEU B 2 64  ? -18.088 -1.931  2.521   1    36.22  ? 234 LEU B CA  1 
ATOM   2938 C  C   . LEU B 2 64  ? -18.122 -0.631  3.315   1    41.48  ? 234 LEU B C   1 
ATOM   2939 O  O   . LEU B 2 64  ? -18.902 -0.471  4.263   1    39.44  ? 234 LEU B O   1 
ATOM   2940 C  CB  . LEU B 2 64  ? -16.862 -2.769  2.898   1    36.32  ? 234 LEU B CB  1 
ATOM   2941 C  CG  . LEU B 2 64  ? -16.947 -4.264  2.554   1    35.97  ? 234 LEU B CG  1 
ATOM   2942 C  CD1 . LEU B 2 64  ? -15.616 -4.955  2.836   1    32.46  ? 234 LEU B CD1 1 
ATOM   2943 C  CD2 . LEU B 2 64  ? -18.123 -4.969  3.25    1    29.16  ? 234 LEU B CD2 1 
ATOM   2944 N  N   . ALA B 2 65  ? -17.231 0.289   2.928   1    42.33  ? 235 ALA B N   1 
ATOM   2945 C  CA  . ALA B 2 65  ? -17.086 1.544   3.656   1    44.67  ? 235 ALA B CA  1 
ATOM   2946 C  C   . ALA B 2 65  ? -18.417 2.307   3.676   1    42.36  ? 235 ALA B C   1 
ATOM   2947 O  O   . ALA B 2 65  ? -18.84  2.849   4.698   1    39.45  ? 235 ALA B O   1 
ATOM   2948 C  CB  . ALA B 2 65  ? -15.99  2.372   3.014   1    40.11  ? 235 ALA B CB  1 
ATOM   2949 N  N   . VAL B 2 66  ? -19.05  2.374   2.504   1    40.86  ? 236 VAL B N   1 
ATOM   2950 C  CA  . VAL B 2 66  ? -20.322 3.044   2.354   1    40.8   ? 236 VAL B CA  1 
ATOM   2951 C  C   . VAL B 2 66  ? -21.338 2.363   3.278   1    41.09  ? 236 VAL B C   1 
ATOM   2952 O  O   . VAL B 2 66  ? -22.061 3.045   4.006   1    42.9   ? 236 VAL B O   1 
ATOM   2953 C  CB  . VAL B 2 66  ? -20.744 3.1     0.865   1    40.52  ? 236 VAL B CB  1 
ATOM   2954 C  CG1 . VAL B 2 66  ? -22.161 3.638   0.693   1    40.37  ? 236 VAL B CG1 1 
ATOM   2955 C  CG2 . VAL B 2 66  ? -19.777 3.979   0.064   1    34.94  ? 236 VAL B CG2 1 
ATOM   2956 N  N   . ASN B 2 67  ? -21.359 1.028   3.306   1    36.1   ? 237 ASN B N   1 
ATOM   2957 C  CA  . ASN B 2 67  ? -22.271 0.311   4.193   1    39.18  ? 237 ASN B CA  1 
ATOM   2958 C  C   . ASN B 2 67  ? -22.041 0.743   5.644   1    38.57  ? 237 ASN B C   1 
ATOM   2959 O  O   . ASN B 2 67  ? -22.989 0.938   6.41    1    38.37  ? 237 ASN B O   1 
ATOM   2960 C  CB  . ASN B 2 67  ? -22.219 -1.21   3.982   1    37.13  ? 237 ASN B CB  1 
ATOM   2961 C  CG  . ASN B 2 67  ? -22.967 -1.967  5.054   1    38.77  ? 237 ASN B CG  1 
ATOM   2962 O  OD1 . ASN B 2 67  ? -22.385 -2.311  6.084   1    47.9   ? 237 ASN B OD1 1 
ATOM   2963 N  ND2 . ASN B 2 67  ? -24.249 -2.241  4.873   1    37.88  ? 237 ASN B ND2 1 
ATOM   2964 N  N   . TYR B 2 68  ? -20.768 0.816   6.043   1    36.06  ? 238 TYR B N   1 
ATOM   2965 C  CA  . TYR B 2 68  ? -20.435 1.162   7.414   1    37.39  ? 238 TYR B CA  1 
ATOM   2966 C  C   . TYR B 2 68  ? -20.903 2.577   7.747   1    37.51  ? 238 TYR B C   1 
ATOM   2967 O  O   . TYR B 2 68  ? -21.366 2.841   8.855   1    38.99  ? 238 TYR B O   1 
ATOM   2968 C  CB  . TYR B 2 68  ? -18.93  1.077   7.663   1    35.06  ? 238 TYR B CB  1 
ATOM   2969 C  CG  . TYR B 2 68  ? -18.327 -0.301  7.436   1    33.51  ? 238 TYR B CG  1 
ATOM   2970 C  CD1 . TYR B 2 68  ? -19.116 -1.441  7.279   1    31.96  ? 238 TYR B CD1 1 
ATOM   2971 C  CD2 . TYR B 2 68  ? -16.951 -0.436  7.377   1    32.06  ? 238 TYR B CD2 1 
ATOM   2972 C  CE1 . TYR B 2 68  ? -18.552 -2.685  7.021   1    32.44  ? 238 TYR B CE1 1 
ATOM   2973 C  CE2 . TYR B 2 68  ? -16.375 -1.668  7.14    1    31.75  ? 238 TYR B CE2 1 
ATOM   2974 C  CZ  . TYR B 2 68  ? -17.167 -2.787  6.963   1    32.66  ? 238 TYR B CZ  1 
ATOM   2975 O  OH  . TYR B 2 68  ? -16.5   -3.946  6.706   1    32.89  ? 238 TYR B OH  1 
ATOM   2976 N  N   . ILE B 2 69  ? -20.761 3.482   6.775   1    37.09  ? 239 ILE B N   1 
ATOM   2977 C  CA  . ILE B 2 69  ? -21.088 4.88    6.984   1    39.7   ? 239 ILE B CA  1 
ATOM   2978 C  C   . ILE B 2 69  ? -22.59  5.016   7.173   1    43.64  ? 239 ILE B C   1 
ATOM   2979 O  O   . ILE B 2 69  ? -23.023 5.719   8.091   1    45.63  ? 239 ILE B O   1 
ATOM   2980 C  CB  . ILE B 2 69  ? -20.61  5.713   5.793   1    41     ? 239 ILE B CB  1 
ATOM   2981 C  CG1 . ILE B 2 69  ? -19.095 5.821   5.786   1    39.56  ? 239 ILE B CG1 1 
ATOM   2982 C  CG2 . ILE B 2 69  ? -21.297 7.07    5.784   1    38.79  ? 239 ILE B CG2 1 
ATOM   2983 C  CD1 . ILE B 2 69  ? -18.534 6.301   4.461   1    37.61  ? 239 ILE B CD1 1 
ATOM   2984 N  N   . ASP B 2 70  ? -23.36  4.306   6.324   1    38.37  ? 240 ASP B N   1 
ATOM   2985 C  CA  . ASP B 2 70  ? -24.805 4.423   6.336   1    36.67  ? 240 ASP B CA  1 
ATOM   2986 C  C   . ASP B 2 70  ? -25.376 3.837   7.615   1    38.94  ? 240 ASP B C   1 
ATOM   2987 O  O   . ASP B 2 70  ? -26.353 4.373   8.143   1    43.25  ? 240 ASP B O   1 
ATOM   2988 C  CB  . ASP B 2 70  ? -25.412 3.846   5.078   1    38.64  ? 240 ASP B CB  1 
ATOM   2989 C  CG  . ASP B 2 70  ? -25.24  4.726   3.853   1    44.18  ? 240 ASP B CG  1 
ATOM   2990 O  OD1 . ASP B 2 70  ? -25.149 5.958   4.03    1    47.36  ? 240 ASP B OD1 1 
ATOM   2991 O  OD2 . ASP B 2 70  ? -25.148 4.175   2.743   1    47.52  ? 240 ASP B OD2 1 
ATOM   2992 N  N   . ARG B 2 71  ? -24.779 2.735   8.087   1    38.11  ? 241 ARG B N   1 
ATOM   2993 C  CA  . ARG B 2 71  ? -25.232 2.088   9.307   1    38.6   ? 241 ARG B CA  1 
ATOM   2994 C  C   . ARG B 2 71  ? -24.877 2.974   10.508  1    41.94  ? 241 ARG B C   1 
ATOM   2995 O  O   . ARG B 2 71  ? -25.693 3.149   11.416  1    37.56  ? 241 ARG B O   1 
ATOM   2996 C  CB  . ARG B 2 71  ? -24.642 0.682   9.435   1    41.32  ? 241 ARG B CB  1 
ATOM   2997 C  CG  . ARG B 2 71  ? -25.427 -0.382  8.678   1    38.57  ? 241 ARG B CG  1 
ATOM   2998 C  CD  . ARG B 2 71  ? -24.595 -1.626  8.333   1    39.43  ? 241 ARG B CD  1 
ATOM   2999 N  NE  . ARG B 2 71  ? -24.341 -2.431  9.523   1    39.27  ? 241 ARG B NE  1 
ATOM   3000 C  CZ  . ARG B 2 71  ? -23.281 -3.194  9.69    1    38.27  ? 241 ARG B CZ  1 
ATOM   3001 N  NH1 . ARG B 2 71  ? -22.38  -3.342  8.727   1    35.39  ? 241 ARG B NH1 1 
ATOM   3002 N  NH2 . ARG B 2 71  ? -23.134 -3.817  10.847  1    37.25  ? 241 ARG B NH2 1 
ATOM   3003 N  N   . PHE B 2 72  ? -23.675 3.578   10.456  1    37.25  ? 242 PHE B N   1 
ATOM   3004 C  CA  . PHE B 2 72  ? -23.242 4.462   11.518  1    39.12  ? 242 PHE B CA  1 
ATOM   3005 C  C   . PHE B 2 72  ? -24.207 5.648   11.653  1    42.18  ? 242 PHE B C   1 
ATOM   3006 O  O   . PHE B 2 72  ? -24.659 5.962   12.759  1    44.1   ? 242 PHE B O   1 
ATOM   3007 C  CB  . PHE B 2 72  ? -21.795 4.885   11.25   1    35.69  ? 242 PHE B CB  1 
ATOM   3008 C  CG  . PHE B 2 72  ? -21.197 5.663   12.413  1    37.53  ? 242 PHE B CG  1 
ATOM   3009 C  CD1 . PHE B 2 72  ? -20.544 5.009   13.441  1    36.02  ? 242 PHE B CD1 1 
ATOM   3010 C  CD2 . PHE B 2 72  ? -21.283 7.047   12.485  1    37.53  ? 242 PHE B CD2 1 
ATOM   3011 C  CE1 . PHE B 2 72  ? -20.018 5.745   14.499  1    37.29  ? 242 PHE B CE1 1 
ATOM   3012 C  CE2 . PHE B 2 72  ? -20.748 7.754   13.551  1    37.42  ? 242 PHE B CE2 1 
ATOM   3013 C  CZ  . PHE B 2 72  ? -20.107 7.107   14.549  1    34.58  ? 242 PHE B CZ  1 
ATOM   3014 N  N   . LEU B 2 73  ? -24.473 6.326   10.531  1    40.33  ? 243 LEU B N   1 
ATOM   3015 C  CA  . LEU B 2 73  ? -25.318 7.512   10.488  1    45.63  ? 243 LEU B CA  1 
ATOM   3016 C  C   . LEU B 2 73  ? -26.771 7.152   10.781  1    48.71  ? 243 LEU B C   1 
ATOM   3017 O  O   . LEU B 2 73  ? -27.57  8.06    11.007  1    48.54  ? 243 LEU B O   1 
ATOM   3018 C  CB  . LEU B 2 73  ? -25.262 8.211   9.129   1    40.52  ? 243 LEU B CB  1 
ATOM   3019 C  CG  . LEU B 2 73  ? -23.904 8.776   8.738   1    40.39  ? 243 LEU B CG  1 
ATOM   3020 C  CD1 . LEU B 2 73  ? -23.978 9.474   7.407   1    36.36  ? 243 LEU B CD1 1 
ATOM   3021 C  CD2 . LEU B 2 73  ? -23.324 9.656   9.886   1    44.17  ? 243 LEU B CD2 1 
ATOM   3022 N  N   . SER B 2 74  ? -27.108 5.85    10.712  1    47     ? 244 SER B N   1 
ATOM   3023 C  CA  . SER B 2 74  ? -28.446 5.394   11.063  1    47.59  ? 244 SER B CA  1 
ATOM   3024 C  C   . SER B 2 74  ? -28.674 5.493   12.578  1    49.29  ? 244 SER B C   1 
ATOM   3025 O  O   . SER B 2 74  ? -29.812 5.678   12.982  1    50.82  ? 244 SER B O   1 
ATOM   3026 C  CB  . SER B 2 74  ? -28.735 4.002   10.533  1    46.08  ? 244 SER B CB  1 
ATOM   3027 O  OG  . SER B 2 74  ? -28.913 3.972   9.118   1    48.19  ? 244 SER B OG  1 
ATOM   3028 N  N   . SER B 2 75  ? -27.615 5.422   13.419  1    45.03  ? 245 SER B N   1 
ATOM   3029 C  CA  . SER B 2 75  ? -27.839 5.589   14.854  1    48.87  ? 245 SER B CA  1 
ATOM   3030 C  C   . SER B 2 75  ? -27.062 6.739   15.496  1    46.58  ? 245 SER B C   1 
ATOM   3031 O  O   . SER B 2 75  ? -27.256 7.016   16.668  1    51.17  ? 245 SER B O   1 
ATOM   3032 C  CB  . SER B 2 75  ? -27.629 4.333   15.637  1    46.77  ? 245 SER B CB  1 
ATOM   3033 O  OG  . SER B 2 75  ? -26.243 4.091   15.714  1    56.98  ? 245 SER B OG  1 
ATOM   3034 N  N   . MET B 2 76  ? -26.176 7.401   14.758  1    47.26  ? 246 MET B N   1 
ATOM   3035 C  CA  . MET B 2 76  ? -25.294 8.392   15.374  1    44.81  ? 246 MET B CA  1 
ATOM   3036 C  C   . MET B 2 76  ? -25.415 9.704   14.621  1    44.42  ? 246 MET B C   1 
ATOM   3037 O  O   . MET B 2 76  ? -25.147 9.808   13.424  1    47.52  ? 246 MET B O   1 
ATOM   3038 C  CB  . MET B 2 76  ? -23.817 7.977   15.334  1    43.1   ? 246 MET B CB  1 
ATOM   3039 C  CG  . MET B 2 76  ? -23.541 6.667   15.989  1    41.24  ? 246 MET B CG  1 
ATOM   3040 S  SD  . MET B 2 76  ? -23.709 6.823   17.763  1    48.58  ? 246 MET B SD  1 
ATOM   3041 C  CE  . MET B 2 76  ? -22.183 7.568   18.358  1    42.24  ? 246 MET B CE  1 
ATOM   3042 N  N   . SER B 2 77  ? -25.861 10.7    15.36   1    46.29  ? 247 SER B N   1 
ATOM   3043 C  CA  . SER B 2 77  ? -25.998 12.051  14.865  1    48.92  ? 247 SER B CA  1 
ATOM   3044 C  C   . SER B 2 77  ? -24.59  12.659  14.721  1    50.27  ? 247 SER B C   1 
ATOM   3045 O  O   . SER B 2 77  ? -23.764 12.51   15.626  1    51.17  ? 247 SER B O   1 
ATOM   3046 C  CB  . SER B 2 77  ? -26.857 12.721  15.873  1    45.63  ? 247 SER B CB  1 
ATOM   3047 O  OG  . SER B 2 77  ? -27.217 13.985  15.409  1    50.62  ? 247 SER B OG  1 
ATOM   3048 N  N   . VAL B 2 78  ? -24.286 13.276  13.565  1    48.92  ? 248 VAL B N   1 
ATOM   3049 C  CA  . VAL B 2 78  ? -22.936 13.74   13.239  1    47.6   ? 248 VAL B CA  1 
ATOM   3050 C  C   . VAL B 2 78  ? -22.949 15.154  12.663  1    51.14  ? 248 VAL B C   1 
ATOM   3051 O  O   . VAL B 2 78  ? -23.722 15.453  11.762  1    58.58  ? 248 VAL B O   1 
ATOM   3052 C  CB  . VAL B 2 78  ? -22.273 12.76   12.261  1    46.26  ? 248 VAL B CB  1 
ATOM   3053 C  CG1 . VAL B 2 78  ? -20.978 13.281  11.671  1    47.48  ? 248 VAL B CG1 1 
ATOM   3054 C  CG2 . VAL B 2 78  ? -22.008 11.413  12.928  1    47.02  ? 248 VAL B CG2 1 
ATOM   3055 N  N   . LEU B 2 79  ? -22.095 16.038  13.206  1    54.57  ? 249 LEU B N   1 
ATOM   3056 C  CA  . LEU B 2 79  ? -21.913 17.391  12.691  1    54.05  ? 249 LEU B CA  1 
ATOM   3057 C  C   . LEU B 2 79  ? -21.124 17.332  11.371  1    57.61  ? 249 LEU B C   1 
ATOM   3058 O  O   . LEU B 2 79  ? -20.245 16.477  11.196  1    51.18  ? 249 LEU B O   1 
ATOM   3059 C  CB  . LEU B 2 79  ? -21.154 18.223  13.715  1    53.35  ? 249 LEU B CB  1 
ATOM   3060 C  CG  . LEU B 2 79  ? -21.91  18.695  14.963  1    58.55  ? 249 LEU B CG  1 
ATOM   3061 C  CD1 . LEU B 2 79  ? -21.07  19.773  15.667  1    51.99  ? 249 LEU B CD1 1 
ATOM   3062 C  CD2 . LEU B 2 79  ? -23.333 19.18   14.673  1    57.08  ? 249 LEU B CD2 1 
ATOM   3063 N  N   . ARG B 2 80  ? -21.41  18.28   10.463  1    56.31  ? 250 ARG B N   1 
ATOM   3064 C  CA  . ARG B 2 80  ? -20.877 18.232  9.105   1    54.65  ? 250 ARG B CA  1 
ATOM   3065 C  C   . ARG B 2 80  ? -19.349 18.242  9.122   1    53     ? 250 ARG B C   1 
ATOM   3066 O  O   . ARG B 2 80  ? -18.743 17.61   8.255   1    50.28  ? 250 ARG B O   1 
ATOM   3067 C  CB  . ARG B 2 80  ? -21.379 19.395  8.238   1    56.83  ? 250 ARG B CB  1 
ATOM   3068 C  CG  . ARG B 2 80  ? -20.703 20.721  8.578   1    60.09  ? 250 ARG B CG  1 
ATOM   3069 C  CD  . ARG B 2 80  ? -21.381 21.863  7.892   1    60.75  ? 250 ARG B CD  1 
ATOM   3070 N  NE  . ARG B 2 80  ? -22.812 21.899  8.206   1    63.08  ? 250 ARG B NE  1 
ATOM   3071 C  CZ  . ARG B 2 80  ? -23.692 22.685  7.585   1    67.52  ? 250 ARG B CZ  1 
ATOM   3072 N  NH1 . ARG B 2 80  ? -23.314 23.462  6.584   1    68.64  ? 250 ARG B NH1 1 
ATOM   3073 N  NH2 . ARG B 2 80  ? -24.957 22.654  7.943   1    67.95  ? 250 ARG B NH2 1 
ATOM   3074 N  N   . GLY B 2 81  ? -18.753 18.918  10.131  1    50.71  ? 251 GLY B N   1 
ATOM   3075 C  CA  . GLY B 2 81  ? -17.31  18.996  10.325  1    48.9   ? 251 GLY B CA  1 
ATOM   3076 C  C   . GLY B 2 81  ? -16.662 17.654  10.701  1    47.47  ? 251 GLY B C   1 
ATOM   3077 O  O   . GLY B 2 81  ? -15.44  17.524  10.73   1    46.76  ? 251 GLY B O   1 
ATOM   3078 N  N   . LYS B 2 82  ? -17.493 16.651  10.992  1    45.23  ? 252 LYS B N   1 
ATOM   3079 C  CA  . LYS B 2 82  ? -17.03  15.362  11.454  1    44.24  ? 252 LYS B CA  1 
ATOM   3080 C  C   . LYS B 2 82  ? -17.431 14.29   10.458  1    43.83  ? 252 LYS B C   1 
ATOM   3081 O  O   . LYS B 2 82  ? -17.014 13.15   10.601  1    47.53  ? 252 LYS B O   1 
ATOM   3082 C  CB  . LYS B 2 82  ? -17.57  15.038  12.854  1    43.03  ? 252 LYS B CB  1 
ATOM   3083 C  CG  . LYS B 2 82  ? -17.071 15.948  13.973  1    44.31  ? 252 LYS B CG  1 
ATOM   3084 C  CD  . LYS B 2 82  ? -15.567 15.791  14.127  1    46.34  ? 252 LYS B CD  1 
ATOM   3085 C  CE  . LYS B 2 82  ? -14.943 16.257  15.394  1    48.1   ? 252 LYS B CE  1 
ATOM   3086 N  NZ  . LYS B 2 82  ? -14.682 17.691  15.371  1    51.13  ? 252 LYS B NZ  1 
ATOM   3087 N  N   . LEU B 2 83  ? -18.216 14.641  9.442   1    44.28  ? 253 LEU B N   1 
ATOM   3088 C  CA  . LEU B 2 83  ? -18.656 13.623  8.501   1    44.38  ? 253 LEU B CA  1 
ATOM   3089 C  C   . LEU B 2 83  ? -17.443 12.957  7.845   1    42.98  ? 253 LEU B C   1 
ATOM   3090 O  O   . LEU B 2 83  ? -17.472 11.746  7.597   1    43.16  ? 253 LEU B O   1 
ATOM   3091 C  CB  . LEU B 2 83  ? -19.612 14.2    7.457   1    46.09  ? 253 LEU B CB  1 
ATOM   3092 C  CG  . LEU B 2 83  ? -20.217 13.175  6.485   1    44.4   ? 253 LEU B CG  1 
ATOM   3093 C  CD1 . LEU B 2 83  ? -20.986 12.074  7.201   1    38.49  ? 253 LEU B CD1 1 
ATOM   3094 C  CD2 . LEU B 2 83  ? -21.116 13.852  5.459   1    42.16  ? 253 LEU B CD2 1 
ATOM   3095 N  N   . GLN B 2 84  ? -16.388 13.739  7.58    1    40.28  ? 254 GLN B N   1 
ATOM   3096 C  CA  . GLN B 2 84  ? -15.218 13.188  6.909   1    43.83  ? 254 GLN B CA  1 
ATOM   3097 C  C   . GLN B 2 84  ? -14.441 12.201  7.799   1    42.6   ? 254 GLN B C   1 
ATOM   3098 O  O   . GLN B 2 84  ? -13.851 11.242  7.306   1    40.3   ? 254 GLN B O   1 
ATOM   3099 C  CB  . GLN B 2 84  ? -14.313 14.312  6.412   1    48.59  ? 254 GLN B CB  1 
ATOM   3100 C  CG  . GLN B 2 84  ? -13.348 13.842  5.331   1    50.21  ? 254 GLN B CG  1 
ATOM   3101 C  CD  . GLN B 2 84  ? -12.349 14.885  4.867   1    56.17  ? 254 GLN B CD  1 
ATOM   3102 O  OE1 . GLN B 2 84  ? -11.687 14.678  3.847   1    61.22  ? 254 GLN B OE1 1 
ATOM   3103 N  NE2 . GLN B 2 84  ? -12.189 15.987  5.593   1    60.06  ? 254 GLN B NE2 1 
ATOM   3104 N  N   . LEU B 2 85  ? -14.45  12.43   9.123   1    43.39  ? 255 LEU B N   1 
ATOM   3105 C  CA  . LEU B 2 85  ? -13.732 11.585  10.057  1    41.17  ? 255 LEU B CA  1 
ATOM   3106 C  C   . LEU B 2 85  ? -14.415 10.233  10.11   1    40.24  ? 255 LEU B C   1 
ATOM   3107 O  O   . LEU B 2 85  ? -13.747 9.208   10.137  1    40.93  ? 255 LEU B O   1 
ATOM   3108 C  CB  . LEU B 2 85  ? -13.748 12.256  11.425  1    43.65  ? 255 LEU B CB  1 
ATOM   3109 C  CG  . LEU B 2 85  ? -13.024 11.515  12.556  1    44.74  ? 255 LEU B CG  1 
ATOM   3110 C  CD1 . LEU B 2 85  ? -11.585 11.158  12.213  1    41.51  ? 255 LEU B CD1 1 
ATOM   3111 C  CD2 . LEU B 2 85  ? -13.089 12.373  13.81   1    44.22  ? 255 LEU B CD2 1 
ATOM   3112 N  N   . VAL B 2 86  ? -15.751 10.243  10.124  1    40.57  ? 256 VAL B N   1 
ATOM   3113 C  CA  . VAL B 2 86  ? -16.498 9.001   10.056  1    41.04  ? 256 VAL B CA  1 
ATOM   3114 C  C   . VAL B 2 86  ? -16.101 8.229   8.808   1    39.53  ? 256 VAL B C   1 
ATOM   3115 O  O   . VAL B 2 86  ? -15.643 7.095   8.917   1    40.96  ? 256 VAL B O   1 
ATOM   3116 C  CB  . VAL B 2 86  ? -18.007 9.275   10.075  1    45.04  ? 256 VAL B CB  1 
ATOM   3117 C  CG1 . VAL B 2 86  ? -18.804 7.984   9.874   1    40.89  ? 256 VAL B CG1 1 
ATOM   3118 C  CG2 . VAL B 2 86  ? -18.377 10.002  11.366  1    40.88  ? 256 VAL B CG2 1 
ATOM   3119 N  N   . GLY B 2 87  ? -16.22  8.885   7.646   1    39.36  ? 257 GLY B N   1 
ATOM   3120 C  CA  . GLY B 2 87  ? -15.88  8.309   6.357   1    39.42  ? 257 GLY B CA  1 
ATOM   3121 C  C   . GLY B 2 87  ? -14.459 7.745   6.314   1    41.73  ? 257 GLY B C   1 
ATOM   3122 O  O   . GLY B 2 87  ? -14.224 6.678   5.772   1    36.84  ? 257 GLY B O   1 
ATOM   3123 N  N   . THR B 2 88  ? -13.494 8.475   6.87    1    44.4   ? 258 THR B N   1 
ATOM   3124 C  CA  . THR B 2 88  ? -12.108 8.016   6.88    1    43.86  ? 258 THR B CA  1 
ATOM   3125 C  C   . THR B 2 88  ? -11.986 6.748   7.729   1    43.3   ? 258 THR B C   1 
ATOM   3126 O  O   . THR B 2 88  ? -11.341 5.801   7.302   1    44.74  ? 258 THR B O   1 
ATOM   3127 C  CB  . THR B 2 88  ? -11.194 9.143   7.39    1    46.38  ? 258 THR B CB  1 
ATOM   3128 O  OG1 . THR B 2 88  ? -11.326 10.28   6.534   1    45.72  ? 258 THR B OG1 1 
ATOM   3129 C  CG2 . THR B 2 88  ? -9.741  8.724   7.497   1    44.53  ? 258 THR B CG2 1 
ATOM   3130 N  N   . ALA B 2 89  ? -12.591 6.708   8.93    1    43.85  ? 259 ALA B N   1 
ATOM   3131 C  CA  . ALA B 2 89  ? -12.486 5.514   9.774   1    44.73  ? 259 ALA B CA  1 
ATOM   3132 C  C   . ALA B 2 89  ? -13.198 4.321   9.122   1    42.23  ? 259 ALA B C   1 
ATOM   3133 O  O   . ALA B 2 89  ? -12.747 3.173   9.187   1    40.87  ? 259 ALA B O   1 
ATOM   3134 C  CB  . ALA B 2 89  ? -12.997 5.788   11.173  1    42.05  ? 259 ALA B CB  1 
ATOM   3135 N  N   . ALA B 2 90  ? -14.307 4.625   8.462   1    37.83  ? 260 ALA B N   1 
ATOM   3136 C  CA  . ALA B 2 90  ? -15.003 3.606   7.716   1    37.74  ? 260 ALA B CA  1 
ATOM   3137 C  C   . ALA B 2 90  ? -14.043 3.008   6.688   1    38.57  ? 260 ALA B C   1 
ATOM   3138 O  O   . ALA B 2 90  ? -13.958 1.794   6.561   1    42.04  ? 260 ALA B O   1 
ATOM   3139 C  CB  . ALA B 2 90  ? -16.237 4.205   7.067   1    34.64  ? 260 ALA B CB  1 
ATOM   3140 N  N   . MET B 2 91  ? -13.337 3.854   5.938   1    36.28  ? 261 MET B N   1 
ATOM   3141 C  CA  . MET B 2 91  ? -12.54  3.404   4.804   1    38.46  ? 261 MET B CA  1 
ATOM   3142 C  C   . MET B 2 91  ? -11.345 2.619   5.348   1    40.31  ? 261 MET B C   1 
ATOM   3143 O  O   . MET B 2 91  ? -10.936 1.619   4.747   1    37.45  ? 261 MET B O   1 
ATOM   3144 C  CB  . MET B 2 91  ? -12.088 4.589   3.931   1    40.83  ? 261 MET B CB  1 
ATOM   3145 C  CG  . MET B 2 91  ? -11.548 4.242   2.56    1    44.6   ? 261 MET B CG  1 
ATOM   3146 S  SD  . MET B 2 91  ? -12.818 3.409   1.585   1    47.24  ? 261 MET B SD  1 
ATOM   3147 C  CE  . MET B 2 91  ? -12.289 3.69    -0.103  1    50.9   ? 261 MET B CE  1 
ATOM   3148 N  N   . LEU B 2 92  ? -10.841 3.057   6.515   1    36.8   ? 262 LEU B N   1 
ATOM   3149 C  CA  . LEU B 2 92  ? -9.783  2.33    7.182   1    37.38  ? 262 LEU B CA  1 
ATOM   3150 C  C   . LEU B 2 92  ? -10.244 0.923   7.553   1    39.05  ? 262 LEU B C   1 
ATOM   3151 O  O   . LEU B 2 92  ? -9.536  -0.051  7.301   1    40.32  ? 262 LEU B O   1 
ATOM   3152 C  CB  . LEU B 2 92  ? -9.372  3.111   8.426   1    39.84  ? 262 LEU B CB  1 
ATOM   3153 C  CG  . LEU B 2 92  ? -8.303  2.447   9.306   1    37.23  ? 262 LEU B CG  1 
ATOM   3154 C  CD1 . LEU B 2 92  ? -7.008  2.196   8.545   1    36.32  ? 262 LEU B CD1 1 
ATOM   3155 C  CD2 . LEU B 2 92  ? -8.061  3.303   10.522  1    36.56  ? 262 LEU B CD2 1 
ATOM   3156 N  N   . LEU B 2 93  ? -11.412 0.82    8.193   1    36.81  ? 263 LEU B N   1 
ATOM   3157 C  CA  . LEU B 2 93  ? -11.899 -0.469  8.646   1    35.96  ? 263 LEU B CA  1 
ATOM   3158 C  C   . LEU B 2 93  ? -12.15  -1.407  7.456   1    34.86  ? 263 LEU B C   1 
ATOM   3159 O  O   . LEU B 2 93  ? -11.808 -2.592  7.482   1    32.98  ? 263 LEU B O   1 
ATOM   3160 C  CB  . LEU B 2 93  ? -13.155 -0.218  9.484   1    35.76  ? 263 LEU B CB  1 
ATOM   3161 C  CG  . LEU B 2 93  ? -12.931 0.129   10.96   1    39.73  ? 263 LEU B CG  1 
ATOM   3162 C  CD1 . LEU B 2 93  ? -14.251 0.581   11.573  1    37.59  ? 263 LEU B CD1 1 
ATOM   3163 C  CD2 . LEU B 2 93  ? -12.444 -1.102  11.756  1    40.73  ? 263 LEU B CD2 1 
ATOM   3164 N  N   . ALA B 2 94  ? -12.813 -0.894  6.416   1    34.77  ? 264 ALA B N   1 
ATOM   3165 C  CA  . ALA B 2 94  ? -13.1   -1.65   5.206   1    30.68  ? 264 ALA B CA  1 
ATOM   3166 C  C   . ALA B 2 94  ? -11.792 -2.158  4.602   1    35.24  ? 264 ALA B C   1 
ATOM   3167 O  O   . ALA B 2 94  ? -11.676 -3.316  4.239   1    36.61  ? 264 ALA B O   1 
ATOM   3168 C  CB  . ALA B 2 94  ? -13.804 -0.747  4.239   1    30.94  ? 264 ALA B CB  1 
ATOM   3169 N  N   . SER B 2 95  ? -10.783 -1.288  4.524   1    37.76  ? 265 SER B N   1 
ATOM   3170 C  CA  . SER B 2 95  ? -9.468  -1.66   4.025   1    38.13  ? 265 SER B CA  1 
ATOM   3171 C  C   . SER B 2 95  ? -8.868  -2.81   4.833   1    39.62  ? 265 SER B C   1 
ATOM   3172 O  O   . SER B 2 95  ? -8.409  -3.783  4.25    1    43.86  ? 265 SER B O   1 
ATOM   3173 C  CB  . SER B 2 95  ? -8.542  -0.483  4.021   1    36.6   ? 265 SER B CB  1 
ATOM   3174 O  OG  . SER B 2 95  ? -9.027  0.501   3.129   1    39.84  ? 265 SER B OG  1 
ATOM   3175 N  N   . LYS B 2 96  ? -8.845  -2.683  6.171   1    39.65  ? 266 LYS B N   1 
ATOM   3176 C  CA  . LYS B 2 96  ? -8.33   -3.736  7.024   1    37.19  ? 266 LYS B CA  1 
ATOM   3177 C  C   . LYS B 2 96  ? -9.119  -5.031  6.818   1    35.67  ? 266 LYS B C   1 
ATOM   3178 O  O   . LYS B 2 96  ? -8.552  -6.118  6.875   1    40.15  ? 266 LYS B O   1 
ATOM   3179 C  CB  . LYS B 2 96  ? -8.377  -3.318  8.492   1    39.27  ? 266 LYS B CB  1 
ATOM   3180 C  CG  . LYS B 2 96  ? -7.364  -2.281  8.951   1    40.29  ? 266 LYS B CG  1 
ATOM   3181 C  CD  . LYS B 2 96  ? -7.442  -2.006  10.449  1    36.5   ? 266 LYS B CD  1 
ATOM   3182 C  CE  . LYS B 2 96  ? -6.493  -0.969  10.909  1    39.55  ? 266 LYS B CE  1 
ATOM   3183 N  NZ  . LYS B 2 96  ? -6.679  -0.677  12.339  1    43.35  ? 266 LYS B NZ  1 
ATOM   3184 N  N   . PHE B 2 97  ? -10.423 -4.937  6.574   1    33.09  ? 267 PHE B N   1 
ATOM   3185 C  CA  . PHE B 2 97  ? -11.197 -6.15   6.379   1    33.9   ? 267 PHE B CA  1 
ATOM   3186 C  C   . PHE B 2 97  ? -10.855 -6.836  5.059   1    33.93  ? 267 PHE B C   1 
ATOM   3187 O  O   . PHE B 2 97  ? -10.601 -8.048  5.029   1    32.76  ? 267 PHE B O   1 
ATOM   3188 C  CB  . PHE B 2 97  ? -12.686 -5.829  6.365   1    35.42  ? 267 PHE B CB  1 
ATOM   3189 C  CG  . PHE B 2 97  ? -13.572 -7.064  6.384   1    35.55  ? 267 PHE B CG  1 
ATOM   3190 C  CD1 . PHE B 2 97  ? -13.873 -7.685  7.599   1    31.56  ? 267 PHE B CD1 1 
ATOM   3191 C  CD2 . PHE B 2 97  ? -14.149 -7.536  5.189   1    33.39  ? 267 PHE B CD2 1 
ATOM   3192 C  CE1 . PHE B 2 97  ? -14.737 -8.775  7.607   1    33.8   ? 267 PHE B CE1 1 
ATOM   3193 C  CE2 . PHE B 2 97  ? -14.991 -8.652  5.19    1    29.84  ? 267 PHE B CE2 1 
ATOM   3194 C  CZ  . PHE B 2 97  ? -15.292 -9.264  6.398   1    31.49  ? 267 PHE B CZ  1 
ATOM   3195 N  N   . GLU B 2 98  ? -10.803 -6.041  3.988   1    32.59  ? 268 GLU B N   1 
ATOM   3196 C  CA  . GLU B 2 98  ? -10.933 -6.564  2.634   1    34.35  ? 268 GLU B CA  1 
ATOM   3197 C  C   . GLU B 2 98  ? -9.62   -6.582  1.839   1    36.66  ? 268 GLU B C   1 
ATOM   3198 O  O   . GLU B 2 98  ? -9.496  -7.422  0.945   1    37.15  ? 268 GLU B O   1 
ATOM   3199 C  CB  . GLU B 2 98  ? -11.947 -5.719  1.873   1    33.35  ? 268 GLU B CB  1 
ATOM   3200 C  CG  . GLU B 2 98  ? -12.423 -6.384  0.591   1    36.62  ? 268 GLU B CG  1 
ATOM   3201 C  CD  . GLU B 2 98  ? -12.988 -7.791  0.792   1    38.88  ? 268 GLU B CD  1 
ATOM   3202 O  OE1 . GLU B 2 98  ? -13.568 -8.069  1.845   1    36.07  ? 268 GLU B OE1 1 
ATOM   3203 O  OE2 . GLU B 2 98  ? -12.889 -8.605  -0.137  1    43.71  ? 268 GLU B OE2 1 
ATOM   3204 N  N   . GLU B 2 99  ? -8.665  -5.688  2.167   1    34.04  ? 269 GLU B N   1 
ATOM   3205 C  CA  . GLU B 2 99  ? -7.447  -5.527  1.389   1    35.67  ? 269 GLU B CA  1 
ATOM   3206 C  C   . GLU B 2 99  ? -6.315  -6.424  1.892   1    38.83  ? 269 GLU B C   1 
ATOM   3207 O  O   . GLU B 2 99  ? -6.118  -6.58   3.103   1    40.54  ? 269 GLU B O   1 
ATOM   3208 C  CB  . GLU B 2 99  ? -6.997  -4.069  1.461   1    37.61  ? 269 GLU B CB  1 
ATOM   3209 C  CG  . GLU B 2 99  ? -7.998  -3.1    0.833   1    36.64  ? 269 GLU B CG  1 
ATOM   3210 C  CD  . GLU B 2 99  ? -7.993  -3.114  -0.692  1    42.02  ? 269 GLU B CD  1 
ATOM   3211 O  OE1 . GLU B 2 99  ? -6.947  -3.528  -1.286  1    48.21  ? 269 GLU B OE1 1 
ATOM   3212 O  OE2 . GLU B 2 99  ? -9.029  -2.724  -1.289  1    42.81  ? 269 GLU B OE2 1 
ATOM   3213 N  N   . ILE B 2 100 ? -5.567  -7.008  0.942   1    37     ? 270 ILE B N   1 
ATOM   3214 C  CA  . ILE B 2 100 ? -4.354  -7.741  1.255   1    39.05  ? 270 ILE B CA  1 
ATOM   3215 C  C   . ILE B 2 100 ? -3.353  -6.797  1.905   1    42.55  ? 270 ILE B C   1 
ATOM   3216 O  O   . ILE B 2 100 ? -2.731  -7.146  2.906   1    46.88  ? 270 ILE B O   1 
ATOM   3217 C  CB  . ILE B 2 100 ? -3.758  -8.365  -0.026  1    41.02  ? 270 ILE B CB  1 
ATOM   3218 C  CG1 . ILE B 2 100 ? -4.734  -9.332  -0.692  1    37.67  ? 270 ILE B CG1 1 
ATOM   3219 C  CG2 . ILE B 2 100 ? -2.4    -9.037  0.218   1    37.14  ? 270 ILE B CG2 1 
ATOM   3220 C  CD1 . ILE B 2 100 ? -4.253  -9.79   -2.051  1    38.62  ? 270 ILE B CD1 1 
ATOM   3221 N  N   . TYR B 2 101 ? -3.194  -5.616  1.299   1    45.89  ? 271 TYR B N   1 
ATOM   3222 C  CA  . TYR B 2 101 ? -2.25   -4.594  1.734   1    49.62  ? 271 TYR B CA  1 
ATOM   3223 C  C   . TYR B 2 101 ? -2.992  -3.293  2.016   1    47.45  ? 271 TYR B C   1 
ATOM   3224 O  O   . TYR B 2 101 ? -3.019  -2.402  1.182   1    51.12  ? 271 TYR B O   1 
ATOM   3225 C  CB  . TYR B 2 101 ? -1.2    -4.336  0.644   1    51.56  ? 271 TYR B CB  1 
ATOM   3226 C  CG  . TYR B 2 101 ? -0.324  -5.548  0.381   1    53.94  ? 271 TYR B CG  1 
ATOM   3227 C  CD1 . TYR B 2 101 ? 0.527   -6.017  1.38    1    58.1   ? 271 TYR B CD1 1 
ATOM   3228 C  CD2 . TYR B 2 101 ? -0.37   -6.228  -0.836  1    53.44  ? 271 TYR B CD2 1 
ATOM   3229 C  CE1 . TYR B 2 101 ? 1.316   -7.138  1.181   1    59.79  ? 271 TYR B CE1 1 
ATOM   3230 C  CE2 . TYR B 2 101 ? 0.422   -7.346  -1.048  1    59.56  ? 271 TYR B CE2 1 
ATOM   3231 C  CZ  . TYR B 2 101 ? 1.267   -7.798  -0.038  1    64.19  ? 271 TYR B CZ  1 
ATOM   3232 O  OH  . TYR B 2 101 ? 2.058   -8.906  -0.225  1    75.43  ? 271 TYR B OH  1 
ATOM   3233 N  N   . PRO B 2 102 ? -3.626  -3.135  3.194   1    47.44  ? 272 PRO B N   1 
ATOM   3234 C  CA  . PRO B 2 102 ? -4.328  -1.89   3.498   1    46.43  ? 272 PRO B CA  1 
ATOM   3235 C  C   . PRO B 2 102 ? -3.338  -0.737  3.602   1    46.41  ? 272 PRO B C   1 
ATOM   3236 O  O   . PRO B 2 102 ? -2.2    -0.924  4.012   1    48.41  ? 272 PRO B O   1 
ATOM   3237 C  CB  . PRO B 2 102 ? -5.026  -2.21   4.837   1    45.45  ? 272 PRO B CB  1 
ATOM   3238 C  CG  . PRO B 2 102 ? -4.132  -3.263  5.447   1    45.28  ? 272 PRO B CG  1 
ATOM   3239 C  CD  . PRO B 2 102 ? -3.674  -4.114  4.291   1    44.78  ? 272 PRO B CD  1 
ATOM   3240 N  N   . PRO B 2 103 ? -3.744  0.497   3.251   1    47.5   ? 273 PRO B N   1 
ATOM   3241 C  CA  . PRO B 2 103 ? -2.938  1.679   3.56    1    48.34  ? 273 PRO B CA  1 
ATOM   3242 C  C   . PRO B 2 103 ? -2.811  1.852   5.078   1    52.11  ? 273 PRO B C   1 
ATOM   3243 O  O   . PRO B 2 103 ? -3.692  1.5     5.865   1    54.33  ? 273 PRO B O   1 
ATOM   3244 C  CB  . PRO B 2 103 ? -3.738  2.835   2.939   1    48.31  ? 273 PRO B CB  1 
ATOM   3245 C  CG  . PRO B 2 103 ? -4.708  2.171   1.997   1    50.98  ? 273 PRO B CG  1 
ATOM   3246 C  CD  . PRO B 2 103 ? -5.019  0.815   2.589   1    46.31  ? 273 PRO B CD  1 
ATOM   3247 N  N   . GLU B 2 104 ? -1.681  2.401   5.491   1    54.72  ? 274 GLU B N   1 
ATOM   3248 C  CA  . GLU B 2 104 ? -1.441  2.696   6.888   1    56.96  ? 274 GLU B CA  1 
ATOM   3249 C  C   . GLU B 2 104 ? -2.366  3.822   7.352   1    54.04  ? 274 GLU B C   1 
ATOM   3250 O  O   . GLU B 2 104 ? -2.883  4.596   6.547   1    49.17  ? 274 GLU B O   1 
ATOM   3251 C  CB  . GLU B 2 104 ? 0.009   3.162   7.026   1    65.09  ? 274 GLU B CB  1 
ATOM   3252 C  CG  . GLU B 2 104 ? 1.04    2.079   6.706   1    82.58  ? 274 GLU B CG  1 
ATOM   3253 C  CD  . GLU B 2 104 ? 2.475   2.569   6.822   1    99.14  ? 274 GLU B CD  1 
ATOM   3254 O  OE1 . GLU B 2 104 ? 3.261   1.935   7.57    1    110.46 ? 274 GLU B OE1 1 
ATOM   3255 O  OE2 . GLU B 2 104 ? 2.798   3.602   6.179   1    96.87  ? 274 GLU B OE2 1 
ATOM   3256 N  N   . VAL B 2 105 ? -2.54   3.916   8.674   1    51.37  ? 275 VAL B N   1 
ATOM   3257 C  CA  . VAL B 2 105 ? -3.32   4.969   9.302   1    50.78  ? 275 VAL B CA  1 
ATOM   3258 C  C   . VAL B 2 105 ? -2.8    6.33    8.851   1    53.61  ? 275 VAL B C   1 
ATOM   3259 O  O   . VAL B 2 105 ? -3.586  7.164   8.429   1    53.37  ? 275 VAL B O   1 
ATOM   3260 C  CB  . VAL B 2 105 ? -3.344  4.836   10.834  1    49.17  ? 275 VAL B CB  1 
ATOM   3261 C  CG1 . VAL B 2 105 ? -4.139  5.943   11.473  1    49.35  ? 275 VAL B CG1 1 
ATOM   3262 C  CG2 . VAL B 2 105 ? -3.969  3.504   11.247  1    49.82  ? 275 VAL B CG2 1 
ATOM   3263 N  N   . ALA B 2 106 ? -1.475  6.514   8.887   1    54.09  ? 276 ALA B N   1 
ATOM   3264 C  CA  . ALA B 2 106 ? -0.847  7.74    8.439   1    54.88  ? 276 ALA B CA  1 
ATOM   3265 C  C   . ALA B 2 106 ? -1.374  8.142   7.061   1    58.31  ? 276 ALA B C   1 
ATOM   3266 O  O   . ALA B 2 106 ? -1.751  9.292   6.837   1    64.08  ? 276 ALA B O   1 
ATOM   3267 C  CB  . ALA B 2 106 ? 0.649   7.566   8.468   1    54.58  ? 276 ALA B CB  1 
ATOM   3268 N  N   . GLU B 2 107 ? -1.44   7.177   6.142   1    57.71  ? 277 GLU B N   1 
ATOM   3269 C  CA  . GLU B 2 107 ? -1.938  7.467   4.809   1    63.16  ? 277 GLU B CA  1 
ATOM   3270 C  C   . GLU B 2 107 ? -3.395  7.938   4.858   1    61.65  ? 277 GLU B C   1 
ATOM   3271 O  O   . GLU B 2 107 ? -3.797  8.771   4.045   1    65.57  ? 277 GLU B O   1 
ATOM   3272 C  CB  . GLU B 2 107 ? -1.689  6.272   3.889   1    67.18  ? 277 GLU B CB  1 
ATOM   3273 C  CG  . GLU B 2 107 ? -0.205  6.068   3.572   1    74.4   ? 277 GLU B CG  1 
ATOM   3274 C  CD  . GLU B 2 107 ? 0.071   4.782   2.798   1    94.85  ? 277 GLU B CD  1 
ATOM   3275 O  OE1 . GLU B 2 107 ? 0.58    4.963   1.665   1    112.28 ? 277 GLU B OE1 1 
ATOM   3276 O  OE2 . GLU B 2 107 ? -0.214  3.634   3.269   1    84.54  ? 277 GLU B OE2 1 
ATOM   3277 N  N   . PHE B 2 108 ? -4.182  7.426   5.813   1    52.81  ? 278 PHE B N   1 
ATOM   3278 C  CA  . PHE B 2 108 ? -5.561  7.876   5.944   1    50.7   ? 278 PHE B CA  1 
ATOM   3279 C  C   . PHE B 2 108 ? -5.628  9.289   6.534   1    55.84  ? 278 PHE B C   1 
ATOM   3280 O  O   . PHE B 2 108 ? -6.448  10.091  6.095   1    59.98  ? 278 PHE B O   1 
ATOM   3281 C  CB  . PHE B 2 108 ? -6.399  6.875   6.73    1    48.86  ? 278 PHE B CB  1 
ATOM   3282 C  CG  . PHE B 2 108 ? -6.843  5.713   5.863   1    52.28  ? 278 PHE B CG  1 
ATOM   3283 C  CD1 . PHE B 2 108 ? -7.895  5.862   4.97    1    53.79  ? 278 PHE B CD1 1 
ATOM   3284 C  CD2 . PHE B 2 108 ? -6.186  4.488   5.912   1    52.51  ? 278 PHE B CD2 1 
ATOM   3285 C  CE1 . PHE B 2 108 ? -8.27   4.802   4.16    1    50.81  ? 278 PHE B CE1 1 
ATOM   3286 C  CE2 . PHE B 2 108 ? -6.591  3.427   5.118   1    50.98  ? 278 PHE B CE2 1 
ATOM   3287 C  CZ  . PHE B 2 108 ? -7.636  3.579   4.254   1    49.64  ? 278 PHE B CZ  1 
ATOM   3288 N  N   . VAL B 2 109 ? -4.752  9.609   7.496   1    52.53  ? 279 VAL B N   1 
ATOM   3289 C  CA  . VAL B 2 109 ? -4.679  10.953  8.041   1    54.19  ? 279 VAL B CA  1 
ATOM   3290 C  C   . VAL B 2 109 ? -4.261  11.934  6.944   1    58.85  ? 279 VAL B C   1 
ATOM   3291 O  O   . VAL B 2 109 ? -4.8    13.032  6.854   1    60.05  ? 279 VAL B O   1 
ATOM   3292 C  CB  . VAL B 2 109 ? -3.691  10.994  9.226   1    55.69  ? 279 VAL B CB  1 
ATOM   3293 C  CG1 . VAL B 2 109 ? -3.37   12.422  9.665   1    53.67  ? 279 VAL B CG1 1 
ATOM   3294 C  CG2 . VAL B 2 109 ? -4.167  10.153  10.407  1    50.46  ? 279 VAL B CG2 1 
ATOM   3295 N  N   . TYR B 2 110 ? -3.288  11.533  6.113   1    63.37  ? 280 TYR B N   1 
ATOM   3296 C  CA  . TYR B 2 110 ? -2.772  12.375  5.052   1    62.57  ? 280 TYR B CA  1 
ATOM   3297 C  C   . TYR B 2 110 ? -3.883  12.81   4.092   1    62.54  ? 280 TYR B C   1 
ATOM   3298 O  O   . TYR B 2 110 ? -3.946  13.976  3.696   1    64.06  ? 280 TYR B O   1 
ATOM   3299 C  CB  . TYR B 2 110 ? -1.657  11.624  4.328   1    70.04  ? 280 TYR B CB  1 
ATOM   3300 C  CG  . TYR B 2 110 ? -1.01   12.413  3.195   1    85.98  ? 280 TYR B CG  1 
ATOM   3301 C  CD1 . TYR B 2 110 ? -0.093  13.431  3.478   1    88.42  ? 280 TYR B CD1 1 
ATOM   3302 C  CD2 . TYR B 2 110 ? -1.312  12.148  1.849   1    86.47  ? 280 TYR B CD2 1 
ATOM   3303 C  CE1 . TYR B 2 110 ? 0.506   14.158  2.461   1    89.78  ? 280 TYR B CE1 1 
ATOM   3304 C  CE2 . TYR B 2 110 ? -0.712  12.867  0.824   1    88.67  ? 280 TYR B CE2 1 
ATOM   3305 C  CZ  . TYR B 2 110 ? 0.195   13.877  1.136   1    97.03  ? 280 TYR B CZ  1 
ATOM   3306 O  OH  . TYR B 2 110 ? 0.806   14.616  0.158   1    104.42 ? 280 TYR B OH  1 
ATOM   3307 N  N   . ILE B 2 111 ? -4.765  11.879  3.714   1    63.21  ? 281 ILE B N   1 
ATOM   3308 C  CA  . ILE B 2 111 ? -5.785  12.167  2.707   1    63.04  ? 281 ILE B CA  1 
ATOM   3309 C  C   . ILE B 2 111 ? -6.838  13.147  3.241   1    62.64  ? 281 ILE B C   1 
ATOM   3310 O  O   . ILE B 2 111 ? -7.632  13.654  2.463   1    57.54  ? 281 ILE B O   1 
ATOM   3311 C  CB  . ILE B 2 111 ? -6.444  10.889  2.158   1    59.63  ? 281 ILE B CB  1 
ATOM   3312 C  CG1 . ILE B 2 111 ? -7.005  10.052  3.28    1    57.98  ? 281 ILE B CG1 1 
ATOM   3313 C  CG2 . ILE B 2 111 ? -5.457  10.099  1.306   1    62.72  ? 281 ILE B CG2 1 
ATOM   3314 C  CD1 . ILE B 2 111 ? -8.13   9.116   2.872   1    65.59  ? 281 ILE B CD1 1 
ATOM   3315 N  N   . THR B 2 112 ? -6.763  13.489  4.528   1    62.7   ? 282 THR B N   1 
ATOM   3316 C  CA  . THR B 2 112 ? -7.744  14.417  5.131   1    64.27  ? 282 THR B CA  1 
ATOM   3317 C  C   . THR B 2 112 ? -7.214  15.84   5.14    1    70.44  ? 282 THR B C   1 
ATOM   3318 O  O   . THR B 2 112 ? -7.915  16.705  5.673   1    68.33  ? 282 THR B O   1 
ATOM   3319 C  CB  . THR B 2 112 ? -8.123  13.957  6.538   1    63     ? 282 THR B CB  1 
ATOM   3320 O  OG1 . THR B 2 112 ? -6.964  14.163  7.338   1    64.14  ? 282 THR B OG1 1 
ATOM   3321 C  CG2 . THR B 2 112 ? -8.566  12.506  6.575   1    51.64  ? 282 THR B CG2 1 
ATOM   3322 N  N   . ASP B 2 113 ? -6.032  16.082  4.572   1    74.93  ? 283 ASP B N   1 
ATOM   3323 C  CA  . ASP B 2 113 ? -5.412  17.439  4.558   1    80.03  ? 283 ASP B CA  1 
ATOM   3324 C  C   . ASP B 2 113 ? -5.216  17.92   5.997   1    79.87  ? 283 ASP B C   1 
ATOM   3325 O  O   . ASP B 2 113 ? -5.506  19.097  6.271   1    79.89  ? 283 ASP B O   1 
ATOM   3326 C  CB  . ASP B 2 113 ? -6.206  18.409  3.698   1    81.7   ? 283 ASP B CB  1 
ATOM   3327 C  CG  . ASP B 2 113 ? -5.641  19.817  3.6     1    93.87  ? 283 ASP B CG  1 
ATOM   3328 O  OD1 . ASP B 2 113 ? -4.535  19.967  3.041   1    98.68  ? 283 ASP B OD1 1 
ATOM   3329 O  OD2 . ASP B 2 113 ? -6.311  20.748  4.087   1    92.88  ? 283 ASP B OD2 1 
ATOM   3330 N  N   . ASP B 2 114 ? -4.758  17.034  6.876   1    86.75  ? 284 ASP B N   1 
ATOM   3331 C  CA  . ASP B 2 114 ? -4.498  17.381  8.301   1    91.22  ? 284 ASP B CA  1 
ATOM   3332 C  C   . ASP B 2 114 ? -5.74   17.996  8.951   1    78.6   ? 284 ASP B C   1 
ATOM   3333 O  O   . ASP B 2 114 ? -5.583  18.695  9.965   1    67.24  ? 284 ASP B O   1 
ATOM   3334 C  CB  . ASP B 2 114 ? -3.196  18.154  8.422   1    113.49 ? 284 ASP B CB  1 
ATOM   3335 C  CG  . ASP B 2 114 ? -1.95   17.302  8.232   1    112.97 ? 284 ASP B CG  1 
ATOM   3336 O  OD1 . ASP B 2 114 ? -2.082  16.189  7.681   1    104.24 ? 284 ASP B OD1 1 
ATOM   3337 O  OD2 . ASP B 2 114 ? -0.862  17.752  8.642   1    115.21 ? 284 ASP B OD2 1 
ATOM   3338 N  N   . THR B 2 115 ? -6.922  17.744  8.397   1    74.15  ? 285 THR B N   1 
ATOM   3339 C  CA  . THR B 2 115 ? -8.164  18.155  9.03    1    73.86  ? 285 THR B CA  1 
ATOM   3340 C  C   . THR B 2 115 ? -8.314  17.442  10.375  1    70     ? 285 THR B C   1 
ATOM   3341 O  O   . THR B 2 115 ? -8.913  17.976  11.305  1    74.92  ? 285 THR B O   1 
ATOM   3342 C  CB  . THR B 2 115 ? -9.344  17.854  8.107   1    75.82  ? 285 THR B CB  1 
ATOM   3343 O  OG1 . THR B 2 115 ? -9.152  18.627  6.926   1    80.89  ? 285 THR B OG1 1 
ATOM   3344 C  CG2 . THR B 2 115 ? -10.681 18.224  8.734   1    73.95  ? 285 THR B CG2 1 
ATOM   3345 N  N   . TYR B 2 116 ? -7.796  16.213  10.45   1    66.08  ? 286 TYR B N   1 
ATOM   3346 C  CA  . TYR B 2 116 ? -7.887  15.387  11.644  1    62.98  ? 286 TYR B CA  1 
ATOM   3347 C  C   . TYR B 2 116 ? -6.537  14.774  11.984  1    61.72  ? 286 TYR B C   1 
ATOM   3348 O  O   . TYR B 2 116 ? -5.671  14.642  11.125  1    64     ? 286 TYR B O   1 
ATOM   3349 C  CB  . TYR B 2 116 ? -8.834  14.201  11.486  1    54.67  ? 286 TYR B CB  1 
ATOM   3350 C  CG  . TYR B 2 116 ? -10.185 14.604  10.934  1    53.7   ? 286 TYR B CG  1 
ATOM   3351 C  CD1 . TYR B 2 116 ? -11.047 15.42   11.671  1    50.71  ? 286 TYR B CD1 1 
ATOM   3352 C  CD2 . TYR B 2 116 ? -10.571 14.195  9.664   1    49.6   ? 286 TYR B CD2 1 
ATOM   3353 C  CE1 . TYR B 2 116 ? -12.29  15.775  11.176  1    49.18  ? 286 TYR B CE1 1 
ATOM   3354 C  CE2 . TYR B 2 116 ? -11.813 14.55   9.167   1    50.79  ? 286 TYR B CE2 1 
ATOM   3355 C  CZ  . TYR B 2 116 ? -12.675 15.338  9.918   1    49.92  ? 286 TYR B CZ  1 
ATOM   3356 O  OH  . TYR B 2 116 ? -13.898 15.675  9.387   1    51.73  ? 286 TYR B OH  1 
ATOM   3357 N  N   . THR B 2 117 ? -6.395  14.426  13.265  1    61.11  ? 287 THR B N   1 
ATOM   3358 C  CA  . THR B 2 117 ? -5.183  13.848  13.813  1    59.65  ? 287 THR B CA  1 
ATOM   3359 C  C   . THR B 2 117 ? -5.289  12.338  13.645  1    58.42  ? 287 THR B C   1 
ATOM   3360 O  O   . THR B 2 117 ? -6.387  11.801  13.483  1    54.37  ? 287 THR B O   1 
ATOM   3361 C  CB  . THR B 2 117 ? -5.036  14.231  15.292  1    60.16  ? 287 THR B CB  1 
ATOM   3362 O  OG1 . THR B 2 117 ? -6.134  13.696  16.031  1    55.97  ? 287 THR B OG1 1 
ATOM   3363 C  CG2 . THR B 2 117 ? -4.928  15.733  15.505  1    53.79  ? 287 THR B CG2 1 
ATOM   3364 N  N   . LYS B 2 118 ? -4.133  11.666  13.686  1    59.62  ? 288 LYS B N   1 
ATOM   3365 C  CA  . LYS B 2 118 ? -4.081  10.218  13.826  1    58.53  ? 288 LYS B CA  1 
ATOM   3366 C  C   . LYS B 2 118 ? -4.899  9.767   15.041  1    56.7   ? 288 LYS B C   1 
ATOM   3367 O  O   . LYS B 2 118 ? -5.559  8.734   14.977  1    52.88  ? 288 LYS B O   1 
ATOM   3368 C  CB  . LYS B 2 118 ? -2.616  9.796   13.966  1    60.07  ? 288 LYS B CB  1 
ATOM   3369 C  CG  . LYS B 2 118 ? -2.337  8.315   13.876  1    63.04  ? 288 LYS B CG  1 
ATOM   3370 C  CD  . LYS B 2 118 ? -0.848  8.015   14.02   1    67.63  ? 288 LYS B CD  1 
ATOM   3371 C  CE  . LYS B 2 118 ? -0.583  6.533   13.952  1    78.38  ? 288 LYS B CE  1 
ATOM   3372 N  NZ  . LYS B 2 118 ? 0.682   6.13    14.576  1    85.37  ? 288 LYS B NZ  1 
ATOM   3373 N  N   . LYS B 2 119 ? -4.847  10.54   16.139  1    57.49  ? 289 LYS B N   1 
ATOM   3374 C  CA  . LYS B 2 119 ? -5.519  10.15   17.37   1    59.21  ? 289 LYS B CA  1 
ATOM   3375 C  C   . LYS B 2 119 ? -7.022  10.125  17.133  1    56.79  ? 289 LYS B C   1 
ATOM   3376 O  O   . LYS B 2 119 ? -7.691  9.174   17.508  1    60.42  ? 289 LYS B O   1 
ATOM   3377 C  CB  . LYS B 2 119 ? -5.151  11.064  18.54   1    66.06  ? 289 LYS B CB  1 
ATOM   3378 C  CG  . LYS B 2 119 ? -5.121  10.341  19.871  1    79.75  ? 289 LYS B CG  1 
ATOM   3379 C  CD  . LYS B 2 119 ? -4.409  11.107  20.991  1    86.21  ? 289 LYS B CD  1 
ATOM   3380 C  CE  . LYS B 2 119 ? -5.183  12.247  21.648  1    89.24  ? 289 LYS B CE  1 
ATOM   3381 N  NZ  . LYS B 2 119 ? -6.326  11.771  22.437  1    79.56  ? 289 LYS B NZ  1 
ATOM   3382 N  N   . GLN B 2 120 ? -7.534  11.152  16.455  1    54.85  ? 290 GLN B N   1 
ATOM   3383 C  CA  . GLN B 2 120 ? -8.933  11.228  16.054  1    53.08  ? 290 GLN B CA  1 
ATOM   3384 C  C   . GLN B 2 120 ? -9.367  10.043  15.166  1    50.34  ? 290 GLN B C   1 
ATOM   3385 O  O   . GLN B 2 120 ? -10.462 9.509   15.35   1    48.07  ? 290 GLN B O   1 
ATOM   3386 C  CB  . GLN B 2 120 ? -9.201  12.567  15.36   1    52.41  ? 290 GLN B CB  1 
ATOM   3387 C  CG  . GLN B 2 120 ? -9.427  13.738  16.317  1    54.31  ? 290 GLN B CG  1 
ATOM   3388 C  CD  . GLN B 2 120 ? -9.626  15.035  15.56   1    56.72  ? 290 GLN B CD  1 
ATOM   3389 O  OE1 . GLN B 2 120 ? -8.8    15.437  14.733  1    56.29  ? 290 GLN B OE1 1 
ATOM   3390 N  NE2 . GLN B 2 120 ? -10.767 15.673  15.769  1    55.75  ? 290 GLN B NE2 1 
ATOM   3391 N  N   . VAL B 2 121 ? -8.55   9.645   14.182  1    45.9   ? 291 VAL B N   1 
ATOM   3392 C  CA  . VAL B 2 121 ? -8.94   8.56    13.295  1    45.45  ? 291 VAL B CA  1 
ATOM   3393 C  C   . VAL B 2 121 ? -9.071  7.254   14.09   1    47.81  ? 291 VAL B C   1 
ATOM   3394 O  O   . VAL B 2 121 ? -10.026 6.489   13.931  1    48.98  ? 291 VAL B O   1 
ATOM   3395 C  CB  . VAL B 2 121 ? -7.962  8.404   12.106  1    44.81  ? 291 VAL B CB  1 
ATOM   3396 C  CG1 . VAL B 2 121 ? -8.26   7.172   11.242  1    40.29  ? 291 VAL B CG1 1 
ATOM   3397 C  CG2 . VAL B 2 121 ? -7.913  9.656   11.247  1    42.06  ? 291 VAL B CG2 1 
ATOM   3398 N  N   . LEU B 2 122 ? -8.087  6.978   14.939  1    46.67  ? 292 LEU B N   1 
ATOM   3399 C  CA  . LEU B 2 122 ? -8.111  5.728   15.669  1    48.41  ? 292 LEU B CA  1 
ATOM   3400 C  C   . LEU B 2 122 ? -9.262  5.714   16.663  1    47.44  ? 292 LEU B C   1 
ATOM   3401 O  O   . LEU B 2 122 ? -9.76   4.647   16.957  1    46.36  ? 292 LEU B O   1 
ATOM   3402 C  CB  . LEU B 2 122 ? -6.781  5.562   16.415  1    51.66  ? 292 LEU B CB  1 
ATOM   3403 C  CG  . LEU B 2 122 ? -5.55   5.4     15.528  1    49.33  ? 292 LEU B CG  1 
ATOM   3404 C  CD1 . LEU B 2 122 ? -4.358  5.092   16.396  1    46.9   ? 292 LEU B CD1 1 
ATOM   3405 C  CD2 . LEU B 2 122 ? -5.823  4.335   14.429  1    45.43  ? 292 LEU B CD2 1 
ATOM   3406 N  N   . ARG B 2 123 ? -9.611  6.871   17.245  1    49.1   ? 293 ARG B N   1 
ATOM   3407 C  CA  . ARG B 2 123 ? -10.693 6.927   18.216  1    51.31  ? 293 ARG B CA  1 
ATOM   3408 C  C   . ARG B 2 123 ? -12.038 6.689   17.522  1    49.96  ? 293 ARG B C   1 
ATOM   3409 O  O   . ARG B 2 123 ? -12.893 5.986   18.078  1    47.05  ? 293 ARG B O   1 
ATOM   3410 C  CB  . ARG B 2 123 ? -10.661 8.224   19.032  1    52.44  ? 293 ARG B CB  1 
ATOM   3411 C  CG  . ARG B 2 123 ? -9.474  8.345   19.968  1    58.7   ? 293 ARG B CG  1 
ATOM   3412 C  CD  . ARG B 2 123 ? -9.769  9.213   21.154  1    77.44  ? 293 ARG B CD  1 
ATOM   3413 N  NE  . ARG B 2 123 ? -10.765 8.499   21.971  1    104.16 ? 293 ARG B NE  1 
ATOM   3414 C  CZ  . ARG B 2 123 ? -10.651 8.164   23.258  1    116.02 ? 293 ARG B CZ  1 
ATOM   3415 N  NH1 . ARG B 2 123 ? -11.621 7.498   23.859  1    114.18 ? 293 ARG B NH1 1 
ATOM   3416 N  NH2 . ARG B 2 123 ? -9.575  8.523   23.943  1    121.98 ? 293 ARG B NH2 1 
ATOM   3417 N  N   . MET B 2 124 ? -12.197 7.262   16.309  1    46.57  ? 294 MET B N   1 
ATOM   3418 C  CA  . MET B 2 124 ? -13.376 7.049   15.478  1    45.01  ? 294 MET B CA  1 
ATOM   3419 C  C   . MET B 2 124 ? -13.457 5.583   15.063  1    42.55  ? 294 MET B C   1 
ATOM   3420 O  O   . MET B 2 124 ? -14.549 5.027   14.964  1    41.62  ? 294 MET B O   1 
ATOM   3421 C  CB  . MET B 2 124 ? -13.386 7.946   14.23   1    44.2   ? 294 MET B CB  1 
ATOM   3422 C  CG  . MET B 2 124 ? -14.643 7.822   13.382  1    42.15  ? 294 MET B CG  1 
ATOM   3423 S  SD  . MET B 2 124 ? -16.138 8.398   14.22   1    42.59  ? 294 MET B SD  1 
ATOM   3424 C  CE  . MET B 2 124 ? -15.769 10.151  14.351  1    40.78  ? 294 MET B CE  1 
ATOM   3425 N  N   . GLU B 2 125 ? -12.297 4.962   14.83   1    42.17  ? 295 GLU B N   1 
ATOM   3426 C  CA  . GLU B 2 125 ? -12.254 3.559   14.447  1    41.96  ? 295 GLU B CA  1 
ATOM   3427 C  C   . GLU B 2 125 ? -12.926 2.73    15.541  1    42.12  ? 295 GLU B C   1 
ATOM   3428 O  O   . GLU B 2 125 ? -13.814 1.931   15.238  1    42.88  ? 295 GLU B O   1 
ATOM   3429 C  CB  . GLU B 2 125 ? -10.82  3.109   14.163  1    41.37  ? 295 GLU B CB  1 
ATOM   3430 C  CG  . GLU B 2 125 ? -10.727 1.633   13.802  1    41.93  ? 295 GLU B CG  1 
ATOM   3431 C  CD  . GLU B 2 125 ? -9.349  1.038   13.586  1    46.08  ? 295 GLU B CD  1 
ATOM   3432 O  OE1 . GLU B 2 125 ? -8.612  0.808   14.567  1    43.76  ? 295 GLU B OE1 1 
ATOM   3433 O  OE2 . GLU B 2 125 ? -9.028  0.779   12.396  1    52.05  ? 295 GLU B OE2 1 
ATOM   3434 N  N   . HIS B 2 126 ? -12.485 2.941   16.793  1    40.13  ? 296 HIS B N   1 
ATOM   3435 C  CA  . HIS B 2 126 ? -13.107 2.339   17.952  1    43.58  ? 296 HIS B CA  1 
ATOM   3436 C  C   . HIS B 2 126 ? -14.608 2.614   17.988  1    43.33  ? 296 HIS B C   1 
ATOM   3437 O  O   . HIS B 2 126 ? -15.381 1.683   18.252  1    41.2   ? 296 HIS B O   1 
ATOM   3438 C  CB  . HIS B 2 126 ? -12.483 2.803   19.266  1    49.62  ? 296 HIS B CB  1 
ATOM   3439 C  CG  . HIS B 2 126 ? -11.445 1.864   19.773  1    70.3   ? 296 HIS B CG  1 
ATOM   3440 N  ND1 . HIS B 2 126 ? -10.115 1.951   19.405  1    80.17  ? 296 HIS B ND1 1 
ATOM   3441 C  CD2 . HIS B 2 126 ? -11.541 0.768   20.529  1    82.26  ? 296 HIS B CD2 1 
ATOM   3442 C  CE1 . HIS B 2 126 ? -9.424  0.984   20.001  1    82.98  ? 296 HIS B CE1 1 
ATOM   3443 N  NE2 . HIS B 2 126 ? -10.275 0.23    20.659  1    90.75  ? 296 HIS B NE2 1 
ATOM   3444 N  N   . LEU B 2 127 ? -15.001 3.882   17.763  1    38.22  ? 297 LEU B N   1 
ATOM   3445 C  CA  . LEU B 2 127 ? -16.395 4.265   17.846  1    36.4   ? 297 LEU B CA  1 
ATOM   3446 C  C   . LEU B 2 127 ? -17.221 3.488   16.814  1    37.41  ? 297 LEU B C   1 
ATOM   3447 O  O   . LEU B 2 127 ? -18.281 2.963   17.142  1    34.96  ? 297 LEU B O   1 
ATOM   3448 C  CB  . LEU B 2 127 ? -16.612 5.77    17.698  1    35.04  ? 297 LEU B CB  1 
ATOM   3449 C  CG  . LEU B 2 127 ? -18.059 6.229   17.975  1    35.13  ? 297 LEU B CG  1 
ATOM   3450 C  CD1 . LEU B 2 127 ? -18.488 5.77    19.394  1    34.11  ? 297 LEU B CD1 1 
ATOM   3451 C  CD2 . LEU B 2 127 ? -18.233 7.728   17.864  1    35.16  ? 297 LEU B CD2 1 
ATOM   3452 N  N   . VAL B 2 128 ? -16.747 3.471   15.559  1    37.56  ? 298 VAL B N   1 
ATOM   3453 C  CA  . VAL B 2 128 ? -17.456 2.8     14.491  1    40.42  ? 298 VAL B CA  1 
ATOM   3454 C  C   . VAL B 2 128 ? -17.566 1.304   14.793  1    43.77  ? 298 VAL B C   1 
ATOM   3455 O  O   . VAL B 2 128 ? -18.634 0.722   14.573  1    48.46  ? 298 VAL B O   1 
ATOM   3456 C  CB  . VAL B 2 128 ? -16.84  3.045   13.107  1    41.26  ? 298 VAL B CB  1 
ATOM   3457 C  CG1 . VAL B 2 128 ? -17.502 2.16    12.071  1    39.09  ? 298 VAL B CG1 1 
ATOM   3458 C  CG2 . VAL B 2 128 ? -16.964 4.501   12.687  1    40.43  ? 298 VAL B CG2 1 
ATOM   3459 N  N   . LEU B 2 129 ? -16.492 0.699   15.328  1    41.97  ? 299 LEU B N   1 
ATOM   3460 C  CA  . LEU B 2 129 ? -16.526 -0.705  15.733  1    40.65  ? 299 LEU B CA  1 
ATOM   3461 C  C   . LEU B 2 129 ? -17.587 -0.959  16.799  1    40.56  ? 299 LEU B C   1 
ATOM   3462 O  O   . LEU B 2 129 ? -18.262 -1.978  16.729  1    42.53  ? 299 LEU B O   1 
ATOM   3463 C  CB  . LEU B 2 129 ? -15.161 -1.195  16.199  1    39.74  ? 299 LEU B CB  1 
ATOM   3464 C  CG  . LEU B 2 129 ? -14.14  -1.422  15.076  1    39.83  ? 299 LEU B CG  1 
ATOM   3465 C  CD1 . LEU B 2 129 ? -12.756 -1.744  15.651  1    37     ? 299 LEU B CD1 1 
ATOM   3466 C  CD2 . LEU B 2 129 ? -14.638 -2.53   14.173  1    33.53  ? 299 LEU B CD2 1 
ATOM   3467 N  N   . LYS B 2 130 ? -17.703 -0.048  17.773  1    38.54  ? 300 LYS B N   1 
ATOM   3468 C  CA  . LYS B 2 130 ? -18.696 -0.14   18.836  1    41.43  ? 300 LYS B CA  1 
ATOM   3469 C  C   . LYS B 2 130 ? -20.116 -0.057  18.247  1    43.02  ? 300 LYS B C   1 
ATOM   3470 O  O   . LYS B 2 130 ? -21     -0.842  18.609  1    43.22  ? 300 LYS B O   1 
ATOM   3471 C  CB  . LYS B 2 130 ? -18.471 0.896   19.959  1    44.1   ? 300 LYS B CB  1 
ATOM   3472 C  CG  . LYS B 2 130 ? -19.752 1.256   20.705  1    50.41  ? 300 LYS B CG  1 
ATOM   3473 C  CD  . LYS B 2 130 ? -19.739 2.101   21.974  1    58.61  ? 300 LYS B CD  1 
ATOM   3474 C  CE  . LYS B 2 130 ? -21.12  2.631   22.32   1    58.52  ? 300 LYS B CE  1 
ATOM   3475 N  NZ  . LYS B 2 130 ? -21.201 3.033   23.733  1    61.69  ? 300 LYS B NZ  1 
ATOM   3476 N  N   . VAL B 2 131 ? -20.336 0.914   17.35   1    42.08  ? 301 VAL B N   1 
ATOM   3477 C  CA  . VAL B 2 131 ? -21.657 1.186   16.804  1    42.5   ? 301 VAL B CA  1 
ATOM   3478 C  C   . VAL B 2 131 ? -22.089 0.017   15.914  1    42.85  ? 301 VAL B C   1 
ATOM   3479 O  O   . VAL B 2 131 ? -23.251 -0.371  15.936  1    44.09  ? 301 VAL B O   1 
ATOM   3480 C  CB  . VAL B 2 131 ? -21.679 2.565   16.103  1    42.36  ? 301 VAL B CB  1 
ATOM   3481 C  CG1 . VAL B 2 131 ? -22.923 2.826   15.253  1    39.54  ? 301 VAL B CG1 1 
ATOM   3482 C  CG2 . VAL B 2 131 ? -21.465 3.691   17.1    1    40.49  ? 301 VAL B CG2 1 
ATOM   3483 N  N   . LEU B 2 132 ? -21.152 -0.568  15.155  1    41.87  ? 302 LEU B N   1 
ATOM   3484 C  CA  . LEU B 2 132 ? -21.474 -1.68   14.27   1    41.09  ? 302 LEU B CA  1 
ATOM   3485 C  C   . LEU B 2 132 ? -21.407 -3.013  15.018  1    41.04  ? 302 LEU B C   1 
ATOM   3486 O  O   . LEU B 2 132 ? -21.687 -4.052  14.426  1    40.59  ? 302 LEU B O   1 
ATOM   3487 C  CB  . LEU B 2 132 ? -20.527 -1.674  13.07   1    35.85  ? 302 LEU B CB  1 
ATOM   3488 C  CG  . LEU B 2 132 ? -20.595 -0.407  12.226  1    38.23  ? 302 LEU B CG  1 
ATOM   3489 C  CD1 . LEU B 2 132 ? -19.676 -0.508  11.021  1    36.8   ? 302 LEU B CD1 1 
ATOM   3490 C  CD2 . LEU B 2 132 ? -21.998 -0.038  11.786  1    40.21  ? 302 LEU B CD2 1 
ATOM   3491 N  N   . ALA B 2 133 ? -20.988 -2.97   16.297  1    39.71  ? 303 ALA B N   1 
ATOM   3492 C  CA  . ALA B 2 133 ? -20.735 -4.155  17.102  1    37.39  ? 303 ALA B CA  1 
ATOM   3493 C  C   . ALA B 2 133 ? -19.864 -5.183  16.368  1    38.53  ? 303 ALA B C   1 
ATOM   3494 O  O   . ALA B 2 133 ? -20.107 -6.388  16.48   1    36.12  ? 303 ALA B O   1 
ATOM   3495 C  CB  . ALA B 2 133 ? -22.035 -4.771  17.548  1    33.31  ? 303 ALA B CB  1 
ATOM   3496 N  N   . PHE B 2 134 ? -18.854 -4.703  15.626  1    39.26  ? 304 PHE B N   1 
ATOM   3497 C  CA  . PHE B 2 134 ? -17.908 -5.55   14.902  1    42.88  ? 304 PHE B CA  1 
ATOM   3498 C  C   . PHE B 2 134 ? -18.558 -6.332  13.751  1    43.58  ? 304 PHE B C   1 
ATOM   3499 O  O   . PHE B 2 134 ? -17.922 -7.228  13.204  1    48.62  ? 304 PHE B O   1 
ATOM   3500 C  CB  . PHE B 2 134 ? -17.124 -6.505  15.818  1    41.76  ? 304 PHE B CB  1 
ATOM   3501 C  CG  . PHE B 2 134 ? -16.112 -5.827  16.729  1    47.96  ? 304 PHE B CG  1 
ATOM   3502 C  CD1 . PHE B 2 134 ? -16.527 -5.201  17.92   1    46.96  ? 304 PHE B CD1 1 
ATOM   3503 C  CD2 . PHE B 2 134 ? -14.756 -5.775  16.378  1    47.69  ? 304 PHE B CD2 1 
ATOM   3504 C  CE1 . PHE B 2 134 ? -15.604 -4.564  18.757  1    49.39  ? 304 PHE B CE1 1 
ATOM   3505 C  CE2 . PHE B 2 134 ? -13.841 -5.14   17.224  1    47.74  ? 304 PHE B CE2 1 
ATOM   3506 C  CZ  . PHE B 2 134 ? -14.259 -4.554  18.42   1    46.84  ? 304 PHE B CZ  1 
ATOM   3507 N  N   A ASP B 2 135 ? -19.795 -5.981  13.38   0.5  42.83  ? 305 ASP B N   1 
ATOM   3508 N  N   B ASP B 2 135 ? -19.805 -6.007  13.387  0.5  40.36  ? 305 ASP B N   1 
ATOM   3509 C  CA  A ASP B 2 135 ? -20.473 -6.698  12.313  0.5  44.3   ? 305 ASP B CA  1 
ATOM   3510 C  CA  B ASP B 2 135 ? -20.471 -6.719  12.306  0.5  39.69  ? 305 ASP B CA  1 
ATOM   3511 C  C   A ASP B 2 135 ? -20.062 -6.119  10.966  0.5  42.54  ? 305 ASP B C   1 
ATOM   3512 C  C   B ASP B 2 135 ? -20.054 -6.115  10.972  0.5  39.96  ? 305 ASP B C   1 
ATOM   3513 O  O   A ASP B 2 135 ? -20.807 -5.325  10.401  0.5  45.27  ? 305 ASP B O   1 
ATOM   3514 O  O   B ASP B 2 135 ? -20.78  -5.296  10.425  0.5  42.9   ? 305 ASP B O   1 
ATOM   3515 C  CB  A ASP B 2 135 ? -21.982 -6.661  12.471  0.5  46.26  ? 305 ASP B CB  1 
ATOM   3516 C  CB  B ASP B 2 135 ? -21.98  -6.768  12.497  0.5  37.12  ? 305 ASP B CB  1 
ATOM   3517 C  CG  A ASP B 2 135 ? -22.682 -7.805  11.766  0.5  50.82  ? 305 ASP B CG  1 
ATOM   3518 C  CG  B ASP B 2 135 ? -22.475 -7.676  13.62   0.5  36.53  ? 305 ASP B CG  1 
ATOM   3519 O  OD1 A ASP B 2 135 ? -21.959 -8.714  11.31   0.5  55.13  ? 305 ASP B OD1 1 
ATOM   3520 O  OD1 B ASP B 2 135 ? -21.685 -8.457  14.172  0.5  36.66  ? 305 ASP B OD1 1 
ATOM   3521 O  OD2 A ASP B 2 135 ? -23.928 -7.786  11.684  0.5  58.98  ? 305 ASP B OD2 1 
ATOM   3522 O  OD2 B ASP B 2 135 ? -23.663 -7.611  13.936  0.5  39.71  ? 305 ASP B OD2 1 
ATOM   3523 N  N   . LEU B 2 136 ? -18.897 -6.547  10.451  1    41.09  ? 306 LEU B N   1 
ATOM   3524 C  CA  . LEU B 2 136 ? -18.254 -5.89   9.313   1    39.48  ? 306 LEU B CA  1 
ATOM   3525 C  C   . LEU B 2 136 ? -18.369 -6.674  8.013   1    41.27  ? 306 LEU B C   1 
ATOM   3526 O  O   . LEU B 2 136 ? -18.095 -6.124  6.956   1    39.55  ? 306 LEU B O   1 
ATOM   3527 C  CB  . LEU B 2 136 ? -16.794 -5.599  9.635   1    43.02  ? 306 LEU B CB  1 
ATOM   3528 C  CG  . LEU B 2 136 ? -16.536 -4.714  10.868  1    51.58  ? 306 LEU B CG  1 
ATOM   3529 C  CD1 . LEU B 2 136 ? -15.134 -4.178  10.796  1    50.73  ? 306 LEU B CD1 1 
ATOM   3530 C  CD2 . LEU B 2 136 ? -17.502 -3.549  10.981  1    44.54  ? 306 LEU B CD2 1 
ATOM   3531 N  N   . ALA B 2 137 ? -18.763 -7.959  8.088   1    45.19  ? 307 ALA B N   1 
ATOM   3532 C  CA  . ALA B 2 137 ? -18.843 -8.808  6.903   1    36.11  ? 307 ALA B CA  1 
ATOM   3533 C  C   . ALA B 2 137 ? -20.197 -8.639  6.206   1    34.32  ? 307 ALA B C   1 
ATOM   3534 O  O   . ALA B 2 137 ? -20.953 -9.588  6.069   1    31.11  ? 307 ALA B O   1 
ATOM   3535 C  CB  . ALA B 2 137 ? -18.606 -10.235 7.281   1    30.39  ? 307 ALA B CB  1 
ATOM   3536 N  N   . ALA B 2 138 ? -20.448 -7.423  5.733   1    32.23  ? 308 ALA B N   1 
ATOM   3537 C  CA  . ALA B 2 138 ? -21.703 -7.023  5.143   1    35.4   ? 308 ALA B CA  1 
ATOM   3538 C  C   . ALA B 2 138 ? -21.723 -7.387  3.657   1    38     ? 308 ALA B C   1 
ATOM   3539 O  O   . ALA B 2 138 ? -20.792 -7.09   2.934   1    36.84  ? 308 ALA B O   1 
ATOM   3540 C  CB  . ALA B 2 138 ? -21.824 -5.516  5.292   1    30.66  ? 308 ALA B CB  1 
ATOM   3541 N  N   . PRO B 2 139 ? -22.841 -7.946  3.162   1    38.75  ? 309 PRO B N   1 
ATOM   3542 C  CA  . PRO B 2 139 ? -23.04  -8.14   1.724   1    37.66  ? 309 PRO B CA  1 
ATOM   3543 C  C   . PRO B 2 139 ? -23.086 -6.793  1.036   1    36.25  ? 309 PRO B C   1 
ATOM   3544 O  O   . PRO B 2 139 ? -23.671 -5.86   1.57    1    38.68  ? 309 PRO B O   1 
ATOM   3545 C  CB  . PRO B 2 139 ? -24.431 -8.811  1.622   1    35     ? 309 PRO B CB  1 
ATOM   3546 C  CG  . PRO B 2 139 ? -24.68  -9.358  3.027   1    37.2   ? 309 PRO B CG  1 
ATOM   3547 C  CD  . PRO B 2 139 ? -24.009 -8.353  3.976   1    37.26  ? 309 PRO B CD  1 
ATOM   3548 N  N   . THR B 2 140 ? -22.477 -6.739  -0.151  1    36.92  ? 310 THR B N   1 
ATOM   3549 C  CA  . THR B 2 140 ? -22.424 -5.54   -0.974  1    36.76  ? 310 THR B CA  1 
ATOM   3550 C  C   . THR B 2 140 ? -23.097 -5.841  -2.306  1    36.09  ? 310 THR B C   1 
ATOM   3551 O  O   . THR B 2 140 ? -23.304 -7.002  -2.649  1    38.75  ? 310 THR B O   1 
ATOM   3552 C  CB  . THR B 2 140 ? -20.957 -5.181  -1.247  1    37.78  ? 310 THR B CB  1 
ATOM   3553 O  OG1 . THR B 2 140 ? -20.394 -6.279  -1.989  1    33.4   ? 310 THR B OG1 1 
ATOM   3554 C  CG2 . THR B 2 140 ? -20.188 -4.846  0.02    1    28.49  ? 310 THR B CG2 1 
ATOM   3555 N  N   . ILE B 2 141 ? -23.356 -4.787  -3.083  1    35.13  ? 311 ILE B N   1 
ATOM   3556 C  CA  . ILE B 2 141 ? -23.824 -4.917  -4.452  1    34.37  ? 311 ILE B CA  1 
ATOM   3557 C  C   . ILE B 2 141 ? -22.871 -5.822  -5.224  1    39.8   ? 311 ILE B C   1 
ATOM   3558 O  O   . ILE B 2 141 ? -23.322 -6.693  -5.97   1    46.9   ? 311 ILE B O   1 
ATOM   3559 C  CB  . ILE B 2 141 ? -23.905 -3.512  -5.074  1    34.27  ? 311 ILE B CB  1 
ATOM   3560 C  CG1 . ILE B 2 141 ? -25.113 -2.721  -4.516  1    32.97  ? 311 ILE B CG1 1 
ATOM   3561 C  CG2 . ILE B 2 141 ? -23.899 -3.55   -6.596  1    33.1   ? 311 ILE B CG2 1 
ATOM   3562 C  CD1 . ILE B 2 141 ? -25.028 -1.228  -4.787  1    31.27  ? 311 ILE B CD1 1 
ATOM   3563 N  N   A ASN B 2 142 ? -21.562 -5.629  -5.016  0.5  39     ? 312 ASN B N   1 
ATOM   3564 N  N   B ASN B 2 142 ? -21.562 -5.62   -5.013  0.5  41.82  ? 312 ASN B N   1 
ATOM   3565 C  CA  A ASN B 2 142 ? -20.552 -6.333  -5.794  0.5  36.51  ? 312 ASN B CA  1 
ATOM   3566 C  CA  B ASN B 2 142 ? -20.49  -6.287  -5.747  0.5  41.35  ? 312 ASN B CA  1 
ATOM   3567 C  C   A ASN B 2 142 ? -20.63  -7.832  -5.555  0.5  35.25  ? 312 ASN B C   1 
ATOM   3568 C  C   B ASN B 2 142 ? -20.563 -7.8    -5.536  0.5  37.53  ? 312 ASN B C   1 
ATOM   3569 O  O   A ASN B 2 142 ? -20.486 -8.615  -6.498  0.5  39.63  ? 312 ASN B O   1 
ATOM   3570 O  O   B ASN B 2 142 ? -20.378 -8.572  -6.484  0.5  41.59  ? 312 ASN B O   1 
ATOM   3571 C  CB  A ASN B 2 142 ? -19.136 -5.812  -5.567  0.5  31.4   ? 312 ASN B CB  1 
ATOM   3572 C  CB  B ASN B 2 142 ? -19.15  -5.604  -5.469  0.5  40.72  ? 312 ASN B CB  1 
ATOM   3573 C  CG  A ASN B 2 142 ? -18.907 -4.576  -6.394  0.5  31.21  ? 312 ASN B CG  1 
ATOM   3574 C  CG  B ASN B 2 142 ? -17.942 -6.502  -5.584  0.5  44.45  ? 312 ASN B CG  1 
ATOM   3575 O  OD1 A ASN B 2 142 ? -19.856 -3.85   -6.713  0.5  28.62  ? 312 ASN B OD1 1 
ATOM   3576 O  OD1 B ASN B 2 142 ? -17.292 -6.5    -6.637  0.5  56.91  ? 312 ASN B OD1 1 
ATOM   3577 N  ND2 A ASN B 2 142 ? -17.667 -4.312  -6.754  0.5  30.95  ? 312 ASN B ND2 1 
ATOM   3578 N  ND2 B ASN B 2 142 ? -17.606 -7.261  -4.536  0.5  39.08  ? 312 ASN B ND2 1 
ATOM   3579 N  N   . GLN B 2 143 ? -20.867 -8.218  -4.304  1    32.97  ? 313 GLN B N   1 
ATOM   3580 C  CA  . GLN B 2 143 ? -20.891 -9.636  -3.967  1    33.89  ? 313 GLN B CA  1 
ATOM   3581 C  C   . GLN B 2 143 ? -22.04  -10.331 -4.667  1    33.66  ? 313 GLN B C   1 
ATOM   3582 O  O   . GLN B 2 143 ? -21.902 -11.506 -4.979  1    35.13  ? 313 GLN B O   1 
ATOM   3583 C  CB  . GLN B 2 143 ? -21.019 -9.896  -2.469  1    32.66  ? 313 GLN B CB  1 
ATOM   3584 C  CG  . GLN B 2 143 ? -19.685 -9.719  -1.739  1    30.44  ? 313 GLN B CG  1 
ATOM   3585 C  CD  . GLN B 2 143 ? -19.893 -9.776  -0.24   1    32.48  ? 313 GLN B CD  1 
ATOM   3586 O  OE1 . GLN B 2 143 ? -20.358 -10.769 0.333   1    29.91  ? 313 GLN B OE1 1 
ATOM   3587 N  NE2 . GLN B 2 143 ? -19.615 -8.659  0.407   1    35.51  ? 313 GLN B NE2 1 
ATOM   3588 N  N   . PHE B 2 144 ? -23.143 -9.591  -4.894  1    30.53  ? 314 PHE B N   1 
ATOM   3589 C  CA  . PHE B 2 144 ? -24.268 -10.124 -5.638  1    34.25  ? 314 PHE B CA  1 
ATOM   3590 C  C   . PHE B 2 144 ? -23.928 -10.152 -7.136  1    36.47  ? 314 PHE B C   1 
ATOM   3591 O  O   . PHE B 2 144 ? -24.109 -11.21  -7.764  1    35.9   ? 314 PHE B O   1 
ATOM   3592 C  CB  . PHE B 2 144 ? -25.57  -9.399  -5.297  1    33.08  ? 314 PHE B CB  1 
ATOM   3593 C  CG  . PHE B 2 144 ? -26.128 -9.83   -3.961  1    35.9   ? 314 PHE B CG  1 
ATOM   3594 C  CD1 . PHE B 2 144 ? -26.726 -11.101 -3.81   1    35.39  ? 314 PHE B CD1 1 
ATOM   3595 C  CD2 . PHE B 2 144 ? -26.036 -8.982  -2.85   1    34.26  ? 314 PHE B CD2 1 
ATOM   3596 C  CE1 . PHE B 2 144 ? -27.235 -11.51  -2.572  1    31.72  ? 314 PHE B CE1 1 
ATOM   3597 C  CE2 . PHE B 2 144 ? -26.567 -9.394  -1.607  1    33.58  ? 314 PHE B CE2 1 
ATOM   3598 C  CZ  . PHE B 2 144 ? -27.173 -10.64  -1.469  1    30.68  ? 314 PHE B CZ  1 
ATOM   3599 N  N   . LEU B 2 145 ? -23.432 -9.014  -7.658  1    32.54  ? 315 LEU B N   1 
ATOM   3600 C  CA  . LEU B 2 145 ? -23.076 -8.832  -9.065  1    37.69  ? 315 LEU B CA  1 
ATOM   3601 C  C   . LEU B 2 145 ? -22.18  -9.961  -9.576  1    38.34  ? 315 LEU B C   1 
ATOM   3602 O  O   . LEU B 2 145 ? -22.436 -10.498 -10.649 1    39.61  ? 315 LEU B O   1 
ATOM   3603 C  CB  . LEU B 2 145 ? -22.383 -7.489  -9.31   1    36.52  ? 315 LEU B CB  1 
ATOM   3604 C  CG  . LEU B 2 145 ? -23.312 -6.304  -9.555  1    35.98  ? 315 LEU B CG  1 
ATOM   3605 C  CD1 . LEU B 2 145 ? -22.482 -5.057  -9.725  1    35.15  ? 315 LEU B CD1 1 
ATOM   3606 C  CD2 . LEU B 2 145 ? -24.152 -6.548  -10.778 1    36.28  ? 315 LEU B CD2 1 
ATOM   3607 N  N   . THR B 2 146 ? -21.137 -10.322 -8.809  1    35.54  ? 316 THR B N   1 
ATOM   3608 C  CA  . THR B 2 146 ? -20.147 -11.261 -9.321  1    37.11  ? 316 THR B CA  1 
ATOM   3609 C  C   . THR B 2 146 ? -20.801 -12.635 -9.502  1    39.4   ? 316 THR B C   1 
ATOM   3610 O  O   . THR B 2 146 ? -20.44  -13.402 -10.396 1    37.73  ? 316 THR B O   1 
ATOM   3611 C  CB  . THR B 2 146 ? -18.902 -11.31  -8.431  1    34.16  ? 316 THR B CB  1 
ATOM   3612 O  OG1 . THR B 2 146 ? -19.342 -11.725 -7.145  1    38.05  ? 316 THR B OG1 1 
ATOM   3613 C  CG2 . THR B 2 146 ? -18.187 -9.978  -8.319  1    31.08  ? 316 THR B CG2 1 
ATOM   3614 N  N   . GLN B 2 147 ? -21.782 -12.949 -8.643  1    39.9   ? 317 GLN B N   1 
ATOM   3615 C  CA  . GLN B 2 147 ? -22.532 -14.19  -8.813  1    37.53  ? 317 GLN B CA  1 
ATOM   3616 C  C   . GLN B 2 147 ? -23.435 -14.113 -10.041 1    38.97  ? 317 GLN B C   1 
ATOM   3617 O  O   . GLN B 2 147 ? -23.557 -15.096 -10.774 1    43.72  ? 317 GLN B O   1 
ATOM   3618 C  CB  . GLN B 2 147 ? -23.352 -14.461 -7.564  1    33.96  ? 317 GLN B CB  1 
ATOM   3619 C  CG  . GLN B 2 147 ? -22.484 -14.641 -6.341  1    37.11  ? 317 GLN B CG  1 
ATOM   3620 C  CD  . GLN B 2 147 ? -23.252 -15.208 -5.18   1    40.07  ? 317 GLN B CD  1 
ATOM   3621 O  OE1 . GLN B 2 147 ? -24.267 -15.897 -5.349  1    43.95  ? 317 GLN B OE1 1 
ATOM   3622 N  NE2 . GLN B 2 147 ? -22.731 -14.962 -3.989  1    41.32  ? 317 GLN B NE2 1 
ATOM   3623 N  N   . TYR B 2 148 ? -24.072 -12.95  -10.254 1    35.73  ? 318 TYR B N   1 
ATOM   3624 C  CA  . TYR B 2 148 ? -25.01  -12.816 -11.349 1    36.26  ? 318 TYR B CA  1 
ATOM   3625 C  C   . TYR B 2 148 ? -24.227 -12.979 -12.652 1    38.87  ? 318 TYR B C   1 
ATOM   3626 O  O   . TYR B 2 148 ? -24.719 -13.574 -13.616 1    40.17  ? 318 TYR B O   1 
ATOM   3627 C  CB  . TYR B 2 148 ? -25.773 -11.489 -11.27  1    34.54  ? 318 TYR B CB  1 
ATOM   3628 C  CG  . TYR B 2 148 ? -26.667 -11.236 -10.075 1    32.87  ? 318 TYR B CG  1 
ATOM   3629 C  CD1 . TYR B 2 148 ? -27.006 -12.231 -9.17   1    32.76  ? 318 TYR B CD1 1 
ATOM   3630 C  CD2 . TYR B 2 148 ? -27.167 -9.966  -9.835  1    35.44  ? 318 TYR B CD2 1 
ATOM   3631 C  CE1 . TYR B 2 148 ? -27.81  -11.973 -8.063  1    31.06  ? 318 TYR B CE1 1 
ATOM   3632 C  CE2 . TYR B 2 148 ? -27.987 -9.696  -8.743  1    35.35  ? 318 TYR B CE2 1 
ATOM   3633 C  CZ  . TYR B 2 148 ? -28.322 -10.705 -7.853  1    34.74  ? 318 TYR B CZ  1 
ATOM   3634 O  OH  . TYR B 2 148 ? -29.159 -10.422 -6.798  1    35.95  ? 318 TYR B OH  1 
ATOM   3635 N  N   . PHE B 2 149 ? -22.998 -12.439 -12.671 1    38.59  ? 319 PHE B N   1 
ATOM   3636 C  CA  . PHE B 2 149 ? -22.123 -12.526 -13.829 1    41.12  ? 319 PHE B CA  1 
ATOM   3637 C  C   . PHE B 2 149 ? -21.956 -13.988 -14.283 1    40.96  ? 319 PHE B C   1 
ATOM   3638 O  O   . PHE B 2 149 ? -21.845 -14.259 -15.463 1    42.1   ? 319 PHE B O   1 
ATOM   3639 C  CB  . PHE B 2 149 ? -20.764 -11.91  -13.493 1    39.62  ? 319 PHE B CB  1 
ATOM   3640 C  CG  . PHE B 2 149 ? -20.742 -10.408 -13.308 1    37.03  ? 319 PHE B CG  1 
ATOM   3641 C  CD1 . PHE B 2 149 ? -21.834 -9.631  -13.695 1    37.76  ? 319 PHE B CD1 1 
ATOM   3642 C  CD2 . PHE B 2 149 ? -19.609 -9.789  -12.761 1    34.43  ? 319 PHE B CD2 1 
ATOM   3643 C  CE1 . PHE B 2 149 ? -21.811 -8.249  -13.507 1    35.63  ? 319 PHE B CE1 1 
ATOM   3644 C  CE2 . PHE B 2 149 ? -19.558 -8.413  -12.613 1    32.88  ? 319 PHE B CE2 1 
ATOM   3645 C  CZ  . PHE B 2 149 ? -20.676 -7.652  -12.988 1    39.5   ? 319 PHE B CZ  1 
ATOM   3646 N  N   . LEU B 2 150 ? -21.959 -14.954 -13.362 1    37.45  ? 320 LEU B N   1 
ATOM   3647 C  CA  . LEU B 2 150 ? -21.806 -16.341 -13.762 1    38.88  ? 320 LEU B CA  1 
ATOM   3648 C  C   . LEU B 2 150 ? -22.964 -16.824 -14.655 1    41.52  ? 320 LEU B C   1 
ATOM   3649 O  O   . LEU B 2 150 ? -22.859 -17.917 -15.217 1    43.86  ? 320 LEU B O   1 
ATOM   3650 C  CB  . LEU B 2 150 ? -21.652 -17.237 -12.537 1    35.92  ? 320 LEU B CB  1 
ATOM   3651 C  CG  . LEU B 2 150 ? -20.454 -16.926 -11.661 1    42.18  ? 320 LEU B CG  1 
ATOM   3652 C  CD1 . LEU B 2 150 ? -20.349 -17.791 -10.404 1    36.26  ? 320 LEU B CD1 1 
ATOM   3653 C  CD2 . LEU B 2 150 ? -19.178 -16.97  -12.568 1    42.39  ? 320 LEU B CD2 1 
ATOM   3654 N  N   . HIS B 2 151 ? -24.059 -16.058 -14.787 1    39.13  ? 321 HIS B N   1 
ATOM   3655 C  CA  . HIS B 2 151 ? -25.184 -16.49  -15.618 1    42.63  ? 321 HIS B CA  1 
ATOM   3656 C  C   . HIS B 2 151 ? -25.173 -15.885 -17.027 1    49.31  ? 321 HIS B C   1 
ATOM   3657 O  O   . HIS B 2 151 ? -26.168 -16.009 -17.755 1    56.88  ? 321 HIS B O   1 
ATOM   3658 C  CB  . HIS B 2 151 ? -26.547 -16.215 -14.976 1    38.79  ? 321 HIS B CB  1 
ATOM   3659 C  CG  . HIS B 2 151 ? -26.755 -16.999 -13.729 1    43.84  ? 321 HIS B CG  1 
ATOM   3660 N  ND1 . HIS B 2 151 ? -27.822 -17.846 -13.537 1    41.68  ? 321 HIS B ND1 1 
ATOM   3661 C  CD2 . HIS B 2 151 ? -25.98  -17.071 -12.609 1    40.28  ? 321 HIS B CD2 1 
ATOM   3662 C  CE1 . HIS B 2 151 ? -27.676 -18.409 -12.343 1    44.04  ? 321 HIS B CE1 1 
ATOM   3663 N  NE2 . HIS B 2 151 ? -26.566 -17.951 -11.774 1    41.05  ? 321 HIS B NE2 1 
ATOM   3664 N  N   . GLN B 2 152 ? -24.089 -15.197 -17.399 1    51.17  ? 322 GLN B N   1 
ATOM   3665 C  CA  . GLN B 2 152 ? -23.988 -14.641 -18.736 1    56.45  ? 322 GLN B CA  1 
ATOM   3666 C  C   . GLN B 2 152 ? -23.558 -15.776 -19.652 1    67.25  ? 322 GLN B C   1 
ATOM   3667 O  O   . GLN B 2 152 ? -22.709 -16.591 -19.276 1    68.11  ? 322 GLN B O   1 
ATOM   3668 C  CB  . GLN B 2 152 ? -22.881 -13.608 -18.902 1    50.39  ? 322 GLN B CB  1 
ATOM   3669 C  CG  . GLN B 2 152 ? -22.905 -12.463 -17.911 1    56.28  ? 322 GLN B CG  1 
ATOM   3670 C  CD  . GLN B 2 152 ? -21.59  -11.709 -17.976 1    67.34  ? 322 GLN B CD  1 
ATOM   3671 O  OE1 . GLN B 2 152 ? -21.506 -10.685 -18.67  1    74.69  ? 322 GLN B OE1 1 
ATOM   3672 N  NE2 . GLN B 2 152 ? -20.549 -12.238 -17.33  1    54.27  ? 322 GLN B NE2 1 
ATOM   3673 N  N   . GLN B 2 153 ? -24.13  -15.787 -20.859 1    74.47  ? 323 GLN B N   1 
ATOM   3674 C  CA  . GLN B 2 153 ? -23.737 -16.754 -21.87  1    95.82  ? 323 GLN B CA  1 
ATOM   3675 C  C   . GLN B 2 153 ? -23.613 -16.041 -23.222 1    96.83  ? 323 GLN B C   1 
ATOM   3676 O  O   . GLN B 2 153 ? -24.636 -15.706 -23.844 1    83.62  ? 323 GLN B O   1 
ATOM   3677 C  CB  . GLN B 2 153 ? -24.727 -17.926 -21.857 1    104.59 ? 323 GLN B CB  1 
ATOM   3678 C  CG  . GLN B 2 153 ? -24.389 -19.068 -22.819 1    118.51 ? 323 GLN B CG  1 
ATOM   3679 C  CD  . GLN B 2 153 ? -23.297 -20.006 -22.336 1    127.1  ? 323 GLN B CD  1 
ATOM   3680 O  OE1 . GLN B 2 153 ? -22.586 -19.733 -21.359 1    127.03 ? 323 GLN B OE1 1 
ATOM   3681 N  NE2 . GLN B 2 153 ? -23.136 -21.122 -23.034 1    123.03 ? 323 GLN B NE2 1 
ATOM   3682 N  N   . PRO B 2 154 ? -22.37  -15.74  -23.697 1    83.69  ? 324 PRO B N   1 
ATOM   3683 C  CA  . PRO B 2 154 ? -21.125 -15.909 -22.916 1    76.87  ? 324 PRO B CA  1 
ATOM   3684 C  C   . PRO B 2 154 ? -20.793 -14.727 -21.991 1    70.44  ? 324 PRO B C   1 
ATOM   3685 O  O   . PRO B 2 154 ? -21.47  -13.693 -22.027 1    72.05  ? 324 PRO B O   1 
ATOM   3686 C  CB  . PRO B 2 154 ? -20.09  -15.981 -24.05  1    73.76  ? 324 PRO B CB  1 
ATOM   3687 C  CG  . PRO B 2 154 ? -20.603 -14.964 -25.063 1    70.62  ? 324 PRO B CG  1 
ATOM   3688 C  CD  . PRO B 2 154 ? -22.12  -15.161 -25.031 1    74.21  ? 324 PRO B CD  1 
ATOM   3689 N  N   . ALA B 2 155 ? -19.701 -14.834 -21.213 1    57.83  ? 325 ALA B N   1 
ATOM   3690 C  CA  . ALA B 2 155 ? -19.226 -13.714 -20.404 1    55.63  ? 325 ALA B CA  1 
ATOM   3691 C  C   . ALA B 2 155 ? -18.873 -12.509 -21.275 1    55.79  ? 325 ALA B C   1 
ATOM   3692 O  O   . ALA B 2 155 ? -18.242 -12.661 -22.313 1    65.05  ? 325 ALA B O   1 
ATOM   3693 C  CB  . ALA B 2 155 ? -18.03  -14.142 -19.607 1    48.07  ? 325 ALA B CB  1 
ATOM   3694 N  N   . ASN B 2 156 ? -19.266 -11.31  -20.843 1    53.39  ? 326 ASN B N   1 
ATOM   3695 C  CA  . ASN B 2 156 ? -18.938 -10.072 -21.534 1    51.98  ? 326 ASN B CA  1 
ATOM   3696 C  C   . ASN B 2 156 ? -18.399 -9.101  -20.491 1    49.65  ? 326 ASN B C   1 
ATOM   3697 O  O   . ASN B 2 156 ? -19.11  -8.762  -19.546 1    53.13  ? 326 ASN B O   1 
ATOM   3698 C  CB  . ASN B 2 156 ? -20.113 -9.537  -22.359 1    48.99  ? 326 ASN B CB  1 
ATOM   3699 C  CG  . ASN B 2 156 ? -19.78  -8.297  -23.151 1    55.05  ? 326 ASN B CG  1 
ATOM   3700 O  OD1 . ASN B 2 156 ? -19.215 -7.337  -22.607 1    63.31  ? 326 ASN B OD1 1 
ATOM   3701 N  ND2 . ASN B 2 156 ? -20.102 -8.277  -24.44  1    57.48  ? 326 ASN B ND2 1 
ATOM   3702 N  N   . CYS B 2 157 ? -17.143 -8.672  -20.677 1    49.78  ? 327 CYS B N   1 
ATOM   3703 C  CA  . CYS B 2 157 ? -16.456 -7.761  -19.761 1    50     ? 327 CYS B CA  1 
ATOM   3704 C  C   . CYS B 2 157 ? -17.057 -6.347  -19.801 1    46.29  ? 327 CYS B C   1 
ATOM   3705 O  O   . CYS B 2 157 ? -16.956 -5.637  -18.821 1    44.89  ? 327 CYS B O   1 
ATOM   3706 C  CB  . CYS B 2 157 ? -14.949 -7.743  -20.028 1    55.57  ? 327 CYS B CB  1 
ATOM   3707 S  SG  . CYS B 2 157 ? -14.527 -7.162  -21.696 1    82.66  ? 327 CYS B SG  1 
ATOM   3708 N  N   . LYS B 2 158 ? -17.613 -5.914  -20.947 1    50.76  ? 328 LYS B N   1 
ATOM   3709 C  CA  . LYS B 2 158 ? -18.31  -4.632  -21.035 1    50.44  ? 328 LYS B CA  1 
ATOM   3710 C  C   . LYS B 2 158 ? -19.564 -4.664  -20.15  1    48.13  ? 328 LYS B C   1 
ATOM   3711 O  O   . LYS B 2 158 ? -19.858 -3.707  -19.445 1    45.42  ? 328 LYS B O   1 
ATOM   3712 C  CB  . LYS B 2 158 ? -18.61  -4.269  -22.495 1    57.52  ? 328 LYS B CB  1 
ATOM   3713 C  CG  . LYS B 2 158 ? -17.546 -3.428  -23.19  1    67.8   ? 328 LYS B CG  1 
ATOM   3714 C  CD  . LYS B 2 158 ? -17.189 -3.837  -24.613 1    87.41  ? 328 LYS B CD  1 
ATOM   3715 C  CE  . LYS B 2 158 ? -18.226 -3.724  -25.687 1    95.87  ? 328 LYS B CE  1 
ATOM   3716 N  NZ  . LYS B 2 158 ? -18.741 -2.353  -25.725 1    103.76 ? 328 LYS B NZ  1 
ATOM   3717 N  N   . VAL B 2 159 ? -20.3   -5.785  -20.177 1    47.07  ? 329 VAL B N   1 
ATOM   3718 C  CA  . VAL B 2 159 ? -21.478 -5.977  -19.352 1    42.38  ? 329 VAL B CA  1 
ATOM   3719 C  C   . VAL B 2 159 ? -21.04  -5.892  -17.895 1    41.28  ? 329 VAL B C   1 
ATOM   3720 O  O   . VAL B 2 159 ? -21.626 -5.153  -17.107 1    38.6   ? 329 VAL B O   1 
ATOM   3721 C  CB  . VAL B 2 159 ? -22.186 -7.308  -19.669 1    41.97  ? 329 VAL B CB  1 
ATOM   3722 C  CG1 . VAL B 2 159 ? -23.292 -7.641  -18.667 1    42.87  ? 329 VAL B CG1 1 
ATOM   3723 C  CG2 . VAL B 2 159 ? -22.743 -7.31   -21.082 1    43.27  ? 329 VAL B CG2 1 
ATOM   3724 N  N   . GLU B 2 160 ? -19.961 -6.612  -17.575 1    41.64  ? 330 GLU B N   1 
ATOM   3725 C  CA  . GLU B 2 160 ? -19.53  -6.747  -16.192 1    41.86  ? 330 GLU B CA  1 
ATOM   3726 C  C   . GLU B 2 160 ? -19.11  -5.381  -15.667 1    40.77  ? 330 GLU B C   1 
ATOM   3727 O  O   . GLU B 2 160 ? -19.581 -4.977  -14.622 1    44.1   ? 330 GLU B O   1 
ATOM   3728 C  CB  . GLU B 2 160 ? -18.402 -7.774  -16.057 1    44.11  ? 330 GLU B CB  1 
ATOM   3729 C  CG  . GLU B 2 160 ? -18.834 -9.208  -16.38  1    43.83  ? 330 GLU B CG  1 
ATOM   3730 C  CD  . GLU B 2 160 ? -17.784 -10.25  -16.029 1    46.5   ? 330 GLU B CD  1 
ATOM   3731 O  OE1 . GLU B 2 160 ? -16.79  -9.865  -15.355 1    47.8   ? 330 GLU B OE1 1 
ATOM   3732 O  OE2 . GLU B 2 160 ? -17.935 -11.436 -16.428 1    51.25  ? 330 GLU B OE2 1 
ATOM   3733 N  N   . SER B 2 161 ? -18.262 -4.661  -16.406 1    40.15  ? 331 SER B N   1 
ATOM   3734 C  CA  . SER B 2 161 ? -17.779 -3.358  -15.969 1    40.56  ? 331 SER B CA  1 
ATOM   3735 C  C   . SER B 2 161 ? -18.923 -2.344  -15.873 1    41.06  ? 331 SER B C   1 
ATOM   3736 O  O   . SER B 2 161 ? -18.99  -1.568  -14.919 1    38.66  ? 331 SER B O   1 
ATOM   3737 C  CB  . SER B 2 161 ? -16.64  -2.852  -16.837 1    42.87  ? 331 SER B CB  1 
ATOM   3738 O  OG  . SER B 2 161 ? -15.467 -3.631  -16.64  1    49.22  ? 331 SER B OG  1 
ATOM   3739 N  N   . LEU B 2 162 ? -19.832 -2.369  -16.853 1    41.41  ? 332 LEU B N   1 
ATOM   3740 C  CA  . LEU B 2 162 ? -20.931 -1.423  -16.86  1    42.06  ? 332 LEU B CA  1 
ATOM   3741 C  C   . LEU B 2 162 ? -21.841 -1.661  -15.656 1    40.74  ? 332 LEU B C   1 
ATOM   3742 O  O   . LEU B 2 162 ? -22.359 -0.712  -15.081 1    44.15  ? 332 LEU B O   1 
ATOM   3743 C  CB  . LEU B 2 162 ? -21.699 -1.485  -18.181 1    42.07  ? 332 LEU B CB  1 
ATOM   3744 C  CG  . LEU B 2 162 ? -22.818 -0.457  -18.33  1    41.35  ? 332 LEU B CG  1 
ATOM   3745 C  CD1 . LEU B 2 162 ? -22.277 0.95    -18.165 1    41.69  ? 332 LEU B CD1 1 
ATOM   3746 C  CD2 . LEU B 2 162 ? -23.53  -0.59   -19.67  1    41.65  ? 332 LEU B CD2 1 
ATOM   3747 N  N   . ALA B 2 163 ? -22.03  -2.921  -15.262 1    38.37  ? 333 ALA B N   1 
ATOM   3748 C  CA  . ALA B 2 163 ? -22.882 -3.23   -14.123 1    37.42  ? 333 ALA B CA  1 
ATOM   3749 C  C   . ALA B 2 163 ? -22.244 -2.7    -12.834 1    38.94  ? 333 ALA B C   1 
ATOM   3750 O  O   . ALA B 2 163 ? -22.934 -2.155  -11.974 1    38.74  ? 333 ALA B O   1 
ATOM   3751 C  CB  . ALA B 2 163 ? -23.122 -4.726  -14.059 1    33.27  ? 333 ALA B CB  1 
ATOM   3752 N  N   . MET B 2 164 ? -20.931 -2.898  -12.705 1    36.57  ? 334 MET B N   1 
ATOM   3753 C  CA  . MET B 2 164 ? -20.132 -2.412  -11.59  1    39.84  ? 334 MET B CA  1 
ATOM   3754 C  C   . MET B 2 164 ? -20.255 -0.892  -11.489 1    39.37  ? 334 MET B C   1 
ATOM   3755 O  O   . MET B 2 164 ? -20.43  -0.337  -10.397 1    39.79  ? 334 MET B O   1 
ATOM   3756 C  CB  . MET B 2 164 ? -18.645 -2.783  -11.782 1    44.99  ? 334 MET B CB  1 
ATOM   3757 C  CG  . MET B 2 164 ? -18.26  -4.265  -11.541 1    45.64  ? 334 MET B CG  1 
ATOM   3758 S  SD  . MET B 2 164 ? -18.47  -4.522  -9.762  1    61.83  ? 334 MET B SD  1 
ATOM   3759 C  CE  . MET B 2 164 ? -18.28  -6.308  -9.618  1    57.34  ? 334 MET B CE  1 
ATOM   3760 N  N   . PHE B 2 165 ? -20.155 -0.221  -12.648 1    40.85  ? 335 PHE B N   1 
ATOM   3761 C  CA  . PHE B 2 165 ? -20.225 1.226   -12.749 1    39.09  ? 335 PHE B CA  1 
ATOM   3762 C  C   . PHE B 2 165 ? -21.564 1.738   -12.237 1    42.4   ? 335 PHE B C   1 
ATOM   3763 O  O   . PHE B 2 165 ? -21.607 2.66    -11.43  1    49.73  ? 335 PHE B O   1 
ATOM   3764 C  CB  . PHE B 2 165 ? -20.046 1.612   -14.214 1    40.94  ? 335 PHE B CB  1 
ATOM   3765 C  CG  . PHE B 2 165 ? -20.394 3.052   -14.54  1    41.02  ? 335 PHE B CG  1 
ATOM   3766 C  CD1 . PHE B 2 165 ? -19.687 4.114   -13.979 1    41.1   ? 335 PHE B CD1 1 
ATOM   3767 C  CD2 . PHE B 2 165 ? -21.425 3.337   -15.418 1    42.82  ? 335 PHE B CD2 1 
ATOM   3768 C  CE1 . PHE B 2 165 ? -20.003 5.429   -14.286 1    44.18  ? 335 PHE B CE1 1 
ATOM   3769 C  CE2 . PHE B 2 165 ? -21.743 4.664   -15.732 1    45.86  ? 335 PHE B CE2 1 
ATOM   3770 C  CZ  . PHE B 2 165 ? -21.037 5.711   -15.172 1    44.09  ? 335 PHE B CZ  1 
ATOM   3771 N  N   . LEU B 2 166 ? -22.66  1.117   -12.689 1    43.41  ? 336 LEU B N   1 
ATOM   3772 C  CA  . LEU B 2 166 ? -24.007 1.548   -12.318 1    40.23  ? 336 LEU B CA  1 
ATOM   3773 C  C   . LEU B 2 166 ? -24.25  1.325   -10.828 1    40.45  ? 336 LEU B C   1 
ATOM   3774 O  O   . LEU B 2 166 ? -24.75  2.206   -10.117 1    42.24  ? 336 LEU B O   1 
ATOM   3775 C  CB  . LEU B 2 166 ? -24.994 0.77    -13.179 1    36.3   ? 336 LEU B CB  1 
ATOM   3776 C  CG  . LEU B 2 166 ? -24.985 1.145   -14.664 1    35.01  ? 336 LEU B CG  1 
ATOM   3777 C  CD1 . LEU B 2 166 ? -25.815 0.173   -15.472 1    35.67  ? 336 LEU B CD1 1 
ATOM   3778 C  CD2 . LEU B 2 166 ? -25.452 2.571   -14.878 1    34.48  ? 336 LEU B CD2 1 
ATOM   3779 N  N   . GLY B 2 167 ? -23.854 0.142   -10.357 1    38.55  ? 337 GLY B N   1 
ATOM   3780 C  CA  . GLY B 2 167 ? -23.941 -0.169  -8.945  1    36.5   ? 337 GLY B CA  1 
ATOM   3781 C  C   . GLY B 2 167 ? -23.216 0.889   -8.129  1    39.91  ? 337 GLY B C   1 
ATOM   3782 O  O   . GLY B 2 167 ? -23.699 1.26    -7.065  1    40.69  ? 337 GLY B O   1 
ATOM   3783 N  N   . GLU B 2 168 ? -22.06  1.366   -8.636  1    40.64  ? 338 GLU B N   1 
ATOM   3784 C  CA  . GLU B 2 168 ? -21.274 2.318   -7.862  1    41.15  ? 338 GLU B CA  1 
ATOM   3785 C  C   . GLU B 2 168 ? -21.99  3.665   -7.843  1    44.54  ? 338 GLU B C   1 
ATOM   3786 O  O   . GLU B 2 168 ? -22.007 4.325   -6.806  1    45.86  ? 338 GLU B O   1 
ATOM   3787 C  CB  . GLU B 2 168 ? -19.871 2.534   -8.417  1    39.39  ? 338 GLU B CB  1 
ATOM   3788 C  CG  . GLU B 2 168 ? -18.792 1.884   -7.578  1    37.52  ? 338 GLU B CG  1 
ATOM   3789 C  CD  . GLU B 2 168 ? -17.362 2.07    -8.047  1    38.73  ? 338 GLU B CD  1 
ATOM   3790 O  OE1 . GLU B 2 168 ? -16.872 3.208   -8.068  1    39.46  ? 338 GLU B OE1 1 
ATOM   3791 O  OE2 . GLU B 2 168 ? -16.739 1.054   -8.384  1    39.2   ? 338 GLU B OE2 1 
ATOM   3792 N  N   . LEU B 2 169 ? -22.563 4.076   -8.991  1    43.26  ? 339 LEU B N   1 
ATOM   3793 C  CA  . LEU B 2 169 ? -23.316 5.319   -9.043  1    43.18  ? 339 LEU B CA  1 
ATOM   3794 C  C   . LEU B 2 169 ? -24.334 5.362   -7.911  1    43.71  ? 339 LEU B C   1 
ATOM   3795 O  O   . LEU B 2 169 ? -24.54  6.41    -7.316  1    46.35  ? 339 LEU B O   1 
ATOM   3796 C  CB  . LEU B 2 169 ? -23.982 5.441   -10.409 1    42.29  ? 339 LEU B CB  1 
ATOM   3797 C  CG  . LEU B 2 169 ? -23.019 5.8     -11.545 1    42.33  ? 339 LEU B CG  1 
ATOM   3798 C  CD1 . LEU B 2 169 ? -23.761 5.927   -12.833 1    44.44  ? 339 LEU B CD1 1 
ATOM   3799 C  CD2 . LEU B 2 169 ? -22.241 7.081   -11.229 1    41.84  ? 339 LEU B CD2 1 
ATOM   3800 N  N   . SER B 2 170 ? -24.95  4.215   -7.617  1    42.43  ? 340 SER B N   1 
ATOM   3801 C  CA  . SER B 2 170 ? -26.064 4.166   -6.688  1    44.52  ? 340 SER B CA  1 
ATOM   3802 C  C   . SER B 2 170 ? -25.576 4.467   -5.267  1    46.62  ? 340 SER B C   1 
ATOM   3803 O  O   . SER B 2 170 ? -26.368 4.934   -4.457  1    47.53  ? 340 SER B O   1 
ATOM   3804 C  CB  . SER B 2 170 ? -26.814 2.827   -6.755  1    42.65  ? 340 SER B CB  1 
ATOM   3805 O  OG  . SER B 2 170 ? -26.173 1.795   -6.01   1    36.93  ? 340 SER B OG  1 
ATOM   3806 N  N   . LEU B 2 171 ? -24.29  4.203   -4.967  1    43.03  ? 341 LEU B N   1 
ATOM   3807 C  CA  . LEU B 2 171 ? -23.705 4.508   -3.663  1    40.65  ? 341 LEU B CA  1 
ATOM   3808 C  C   . LEU B 2 171 ? -23.819 6.008   -3.331  1    44.42  ? 341 LEU B C   1 
ATOM   3809 O  O   . LEU B 2 171 ? -23.871 6.402   -2.155  1    42.95  ? 341 LEU B O   1 
ATOM   3810 C  CB  . LEU B 2 171 ? -22.241 4.074   -3.691  1    37.13  ? 341 LEU B CB  1 
ATOM   3811 C  CG  . LEU B 2 171 ? -21.973 2.57    -3.835  1    38.19  ? 341 LEU B CG  1 
ATOM   3812 C  CD1 . LEU B 2 171 ? -20.451 2.341   -3.865  1    39.54  ? 341 LEU B CD1 1 
ATOM   3813 C  CD2 . LEU B 2 171 ? -22.569 1.708   -2.731  1    32.55  ? 341 LEU B CD2 1 
ATOM   3814 N  N   . ILE B 2 172 ? -23.836 6.85    -4.377  1    40.89  ? 342 ILE B N   1 
ATOM   3815 C  CA  . ILE B 2 172 ? -23.702 8.286   -4.231  1    40.56  ? 342 ILE B CA  1 
ATOM   3816 C  C   . ILE B 2 172 ? -24.988 8.894   -3.661  1    46.18  ? 342 ILE B C   1 
ATOM   3817 O  O   . ILE B 2 172 ? -24.919 9.891   -2.941  1    53.48  ? 342 ILE B O   1 
ATOM   3818 C  CB  . ILE B 2 172 ? -23.341 8.916   -5.59   1    39.58  ? 342 ILE B CB  1 
ATOM   3819 C  CG1 . ILE B 2 172 ? -21.987 8.424   -6.122  1    42.43  ? 342 ILE B CG1 1 
ATOM   3820 C  CG2 . ILE B 2 172 ? -23.333 10.441  -5.497  1    39.67  ? 342 ILE B CG2 1 
ATOM   3821 C  CD1 . ILE B 2 172 ? -20.774 9.04    -5.427  1    41.41  ? 342 ILE B CD1 1 
ATOM   3822 N  N   . ASP B 2 173 ? -26.131 8.339   -4.058  1    43.66  ? 343 ASP B N   1 
ATOM   3823 C  CA  . ASP B 2 173 ? -27.429 8.986   -3.735  1    45.86  ? 343 ASP B CA  1 
ATOM   3824 C  C   . ASP B 2 173 ? -28.302 8.179   -2.775  1    46.51  ? 343 ASP B C   1 
ATOM   3825 O  O   . ASP B 2 173 ? -28.992 7.266   -3.238  1    50.32  ? 343 ASP B O   1 
ATOM   3826 C  CB  . ASP B 2 173 ? -28.147 9.298   -5.037  1    43.69  ? 343 ASP B CB  1 
ATOM   3827 C  CG  . ASP B 2 173 ? -27.345 10.091  -6.056  1    49.22  ? 343 ASP B CG  1 
ATOM   3828 O  OD1 . ASP B 2 173 ? -26.884 11.191  -5.706  1    47.21  ? 343 ASP B OD1 1 
ATOM   3829 O  OD2 . ASP B 2 173 ? -27.19  9.601   -7.189  1    50.49  ? 343 ASP B OD2 1 
ATOM   3830 N  N   . ALA B 2 174 ? -28.166 8.461   -1.474  1    41.52  ? 344 ALA B N   1 
ATOM   3831 C  CA  . ALA B 2 174 ? -28.982 7.771   -0.451  1    42.83  ? 344 ALA B CA  1 
ATOM   3832 C  C   . ALA B 2 174 ? -30.419 7.728   -0.955  1    44.58  ? 344 ALA B C   1 
ATOM   3833 O  O   . ALA B 2 174 ? -31.016 6.636   -1.013  1    44.31  ? 344 ALA B O   1 
ATOM   3834 C  CB  . ALA B 2 174 ? -28.876 8.516   0.855   1    43.25  ? 344 ALA B CB  1 
ATOM   3835 N  N   . ASP B 2 175 ? -30.922 8.87    -1.42   1    46.05  ? 345 ASP B N   1 
ATOM   3836 C  CA  . ASP B 2 175 ? -32.259 8.915   -2.071  1    49.57  ? 345 ASP B CA  1 
ATOM   3837 C  C   . ASP B 2 175 ? -32.059 8.864   -3.586  1    50.27  ? 345 ASP B C   1 
ATOM   3838 O  O   . ASP B 2 175 ? -31.516 9.827   -4.143  1    50.77  ? 345 ASP B O   1 
ATOM   3839 C  CB  . ASP B 2 175 ? -33.043 10.159  -1.694  1    48.93  ? 345 ASP B CB  1 
ATOM   3840 C  CG  . ASP B 2 175 ? -34.316 10.43   -2.481  1    51.78  ? 345 ASP B CG  1 
ATOM   3841 O  OD1 . ASP B 2 175 ? -35.029 9.465   -2.807  1    53.51  ? 345 ASP B OD1 1 
ATOM   3842 O  OD2 . ASP B 2 175 ? -34.593 11.612  -2.746  1    57.24  ? 345 ASP B OD2 1 
ATOM   3843 N  N   . PRO B 2 176 ? -32.461 7.78    -4.271  1    50.52  ? 346 PRO B N   1 
ATOM   3844 C  CA  . PRO B 2 176 ? -33.327 6.79    -3.648  1    49.09  ? 346 PRO B CA  1 
ATOM   3845 C  C   . PRO B 2 176 ? -32.819 5.409   -3.273  1    46.88  ? 346 PRO B C   1 
ATOM   3846 O  O   . PRO B 2 176 ? -33.644 4.598   -2.857  1    52.38  ? 346 PRO B O   1 
ATOM   3847 C  CB  . PRO B 2 176 ? -34.158 6.712   -4.921  1    49.19  ? 346 PRO B CB  1 
ATOM   3848 C  CG  . PRO B 2 176 ? -33.147 6.478   -6.003  1    48.38  ? 346 PRO B CG  1 
ATOM   3849 C  CD  . PRO B 2 176 ? -32.127 7.527   -5.654  1    45.29  ? 346 PRO B CD  1 
ATOM   3850 N  N   . TYR B 2 177 ? -31.516 5.161   -3.316  1    42.23  ? 347 TYR B N   1 
ATOM   3851 C  CA  . TYR B 2 177 ? -30.999 3.772   -3.183  1    41.43  ? 347 TYR B CA  1 
ATOM   3852 C  C   . TYR B 2 177 ? -30.948 3.235   -1.751  1    42     ? 347 TYR B C   1 
ATOM   3853 O  O   . TYR B 2 177 ? -30.829 2.012   -1.623  1    45.1   ? 347 TYR B O   1 
ATOM   3854 C  CB  . TYR B 2 177 ? -29.692 3.824   -3.977  1    37.68  ? 347 TYR B CB  1 
ATOM   3855 C  CG  . TYR B 2 177 ? -29.923 4.172   -5.439  1    40.47  ? 347 TYR B CG  1 
ATOM   3856 C  CD1 . TYR B 2 177 ? -30.677 3.344   -6.258  1    41.01  ? 347 TYR B CD1 1 
ATOM   3857 C  CD2 . TYR B 2 177 ? -29.406 5.336   -5.989  1    42.73  ? 347 TYR B CD2 1 
ATOM   3858 C  CE1 . TYR B 2 177 ? -30.899 3.656   -7.587  1    42.32  ? 347 TYR B CE1 1 
ATOM   3859 C  CE2 . TYR B 2 177 ? -29.616 5.658   -7.316  1    43.98  ? 347 TYR B CE2 1 
ATOM   3860 C  CZ  . TYR B 2 177 ? -30.367 4.817   -8.114  1    46.1   ? 347 TYR B CZ  1 
ATOM   3861 O  OH  . TYR B 2 177 ? -30.578 5.14    -9.415  1    48.71  ? 347 TYR B OH  1 
ATOM   3862 N  N   . LEU B 2 178 ? -31.067 4.076   -0.731  1    44.67  ? 348 LEU B N   1 
ATOM   3863 C  CA  . LEU B 2 178 ? -31.111 3.56    0.659   1    46.41  ? 348 LEU B CA  1 
ATOM   3864 C  C   . LEU B 2 178 ? -32.348 2.674   0.837   1    45.54  ? 348 LEU B C   1 
ATOM   3865 O  O   . LEU B 2 178 ? -32.385 1.919   1.816   1    50.34  ? 348 LEU B O   1 
ATOM   3866 C  CB  . LEU B 2 178 ? -31.115 4.714   1.653   1    50.41  ? 348 LEU B CB  1 
ATOM   3867 C  CG  . LEU B 2 178 ? -29.755 5.188   2.165   1    55.49  ? 348 LEU B CG  1 
ATOM   3868 C  CD1 . LEU B 2 178 ? -30.016 6.128   3.321   1    53.35  ? 348 LEU B CD1 1 
ATOM   3869 C  CD2 . LEU B 2 178 ? -28.896 4.019   2.602   1    50.71  ? 348 LEU B CD2 1 
ATOM   3870 N  N   . LYS B 2 179 ? -33.299 2.747   -0.089  1    45.44  ? 349 LYS B N   1 
ATOM   3871 C  CA  . LYS B 2 179 ? -34.565 1.993   0.043   1    50.16  ? 349 LYS B CA  1 
ATOM   3872 C  C   . LYS B 2 179 ? -34.449 0.633   -0.644  1    48.63  ? 349 LYS B C   1 
ATOM   3873 O  O   . LYS B 2 179 ? -35.376 -0.18   -0.509  1    48.63  ? 349 LYS B O   1 
ATOM   3874 C  CB  . LYS B 2 179 ? -35.674 2.836   -0.586  1    59.59  ? 349 LYS B CB  1 
ATOM   3875 C  CG  . LYS B 2 179 ? -35.96  2.581   -2.053  1    71.29  ? 349 LYS B CG  1 
ATOM   3876 C  CD  . LYS B 2 179 ? -37.107 3.428   -2.583  1    66.6   ? 349 LYS B CD  1 
ATOM   3877 C  CE  . LYS B 2 179 ? -36.949 4.879   -2.284  1    71     ? 349 LYS B CE  1 
ATOM   3878 N  NZ  . LYS B 2 179 ? -37.879 5.69    -3.071  1    75.57  ? 349 LYS B NZ  1 
ATOM   3879 N  N   . TYR B 2 180 ? -33.342 0.397   -1.335  1    42.92  ? 350 TYR B N   1 
ATOM   3880 C  CA  . TYR B 2 180 ? -33.206 -0.86   -2.055  1    41.12  ? 350 TYR B CA  1 
ATOM   3881 C  C   . TYR B 2 180 ? -32.068 -1.678  -1.456  1    43.04  ? 350 TYR B C   1 
ATOM   3882 O  O   . TYR B 2 180 ? -30.974 -1.141  -1.147  1    42.61  ? 350 TYR B O   1 
ATOM   3883 C  CB  . TYR B 2 180 ? -32.97  -0.636  -3.554  1    39.89  ? 350 TYR B CB  1 
ATOM   3884 C  CG  . TYR B 2 180 ? -34.031 0.17    -4.298  1    43.81  ? 350 TYR B CG  1 
ATOM   3885 C  CD1 . TYR B 2 180 ? -35.299 -0.346  -4.534  1    41.64  ? 350 TYR B CD1 1 
ATOM   3886 C  CD2 . TYR B 2 180 ? -33.741 1.438   -4.792  1    41.88  ? 350 TYR B CD2 1 
ATOM   3887 C  CE1 . TYR B 2 180 ? -36.242 0.362   -5.263  1    46.1   ? 350 TYR B CE1 1 
ATOM   3888 C  CE2 . TYR B 2 180 ? -34.682 2.175   -5.487  1    44.18  ? 350 TYR B CE2 1 
ATOM   3889 C  CZ  . TYR B 2 180 ? -35.939 1.639   -5.723  1    48.22  ? 350 TYR B CZ  1 
ATOM   3890 O  OH  . TYR B 2 180 ? -36.855 2.367   -6.425  1    45.66  ? 350 TYR B OH  1 
ATOM   3891 N  N   . LEU B 2 181 ? -32.311 -2.994  -1.37   1    40.98  ? 351 LEU B N   1 
ATOM   3892 C  CA  . LEU B 2 181 ? -31.278 -3.93   -0.942  1    40.76  ? 351 LEU B CA  1 
ATOM   3893 C  C   . LEU B 2 181 ? -30.167 -4.058  -1.988  1    40.22  ? 351 LEU B C   1 
ATOM   3894 O  O   . LEU B 2 181 ? -30.396 -3.894  -3.195  1    37.61  ? 351 LEU B O   1 
ATOM   3895 C  CB  . LEU B 2 181 ? -31.902 -5.273  -0.567  1    37.87  ? 351 LEU B CB  1 
ATOM   3896 C  CG  . LEU B 2 181 ? -32.816 -5.231  0.663   1    40.72  ? 351 LEU B CG  1 
ATOM   3897 C  CD1 . LEU B 2 181 ? -33.662 -6.475  0.747   1    40.5   ? 351 LEU B CD1 1 
ATOM   3898 C  CD2 . LEU B 2 181 ? -32.045 -5.049  1.987   1    35.97  ? 351 LEU B CD2 1 
ATOM   3899 N  N   . PRO B 2 182 ? -28.928 -4.35   -1.537  1    38.69  ? 352 PRO B N   1 
ATOM   3900 C  CA  . PRO B 2 182 ? -27.817 -4.623  -2.45   1    36.24  ? 352 PRO B CA  1 
ATOM   3901 C  C   . PRO B 2 182 ? -28.165 -5.61   -3.558  1    35.45  ? 352 PRO B C   1 
ATOM   3902 O  O   . PRO B 2 182 ? -27.86  -5.345  -4.712  1    37.63  ? 352 PRO B O   1 
ATOM   3903 C  CB  . PRO B 2 182 ? -26.709 -5.161  -1.506  1    34.87  ? 352 PRO B CB  1 
ATOM   3904 C  CG  . PRO B 2 182 ? -27.002 -4.479  -0.196  1    37.18  ? 352 PRO B CG  1 
ATOM   3905 C  CD  . PRO B 2 182 ? -28.545 -4.42   -0.114  1    38.84  ? 352 PRO B CD  1 
ATOM   3906 N  N   . SER B 2 183 ? -28.821 -6.719  -3.217  1    34.07  ? 353 SER B N   1 
ATOM   3907 C  CA  . SER B 2 183 ? -29.162 -7.761  -4.169  1    36.3   ? 353 SER B CA  1 
ATOM   3908 C  C   . SER B 2 183 ? -30.063 -7.221  -5.28   1    39.28  ? 353 SER B C   1 
ATOM   3909 O  O   . SER B 2 183 ? -29.977 -7.698  -6.416  1    42.35  ? 353 SER B O   1 
ATOM   3910 C  CB  . SER B 2 183 ? -29.804 -8.959  -3.478  1    36.91  ? 353 SER B CB  1 
ATOM   3911 O  OG  . SER B 2 183 ? -31.095 -8.661  -2.966  1    36.22  ? 353 SER B OG  1 
ATOM   3912 N  N   . VAL B 2 184 ? -30.922 -6.242  -4.942  1    36.69  ? 354 VAL B N   1 
ATOM   3913 C  CA  . VAL B 2 184 ? -31.859 -5.666  -5.901  1    37.67  ? 354 VAL B CA  1 
ATOM   3914 C  C   . VAL B 2 184 ? -31.168 -4.612  -6.784  1    40.36  ? 354 VAL B C   1 
ATOM   3915 O  O   . VAL B 2 184 ? -31.397 -4.556  -7.992  1    41.2   ? 354 VAL B O   1 
ATOM   3916 C  CB  . VAL B 2 184 ? -33.097 -5.088  -5.189  1    36.42  ? 354 VAL B CB  1 
ATOM   3917 C  CG1 . VAL B 2 184 ? -34     -4.313  -6.137  1    36.16  ? 354 VAL B CG1 1 
ATOM   3918 C  CG2 . VAL B 2 184 ? -33.877 -6.17   -4.447  1    32.41  ? 354 VAL B CG2 1 
ATOM   3919 N  N   . ILE B 2 185 ? -30.322 -3.75   -6.204  1    38.02  ? 355 ILE B N   1 
ATOM   3920 C  CA  . ILE B 2 185 ? -29.583 -2.82   -7.043  1    42.22  ? 355 ILE B CA  1 
ATOM   3921 C  C   . ILE B 2 185 ? -28.662 -3.583  -8.01   1    41.96  ? 355 ILE B C   1 
ATOM   3922 O  O   . ILE B 2 185 ? -28.53  -3.203  -9.178  1    39.74  ? 355 ILE B O   1 
ATOM   3923 C  CB  . ILE B 2 185 ? -28.793 -1.809  -6.196  1    42.82  ? 355 ILE B CB  1 
ATOM   3924 C  CG1 . ILE B 2 185 ? -29.722 -0.972  -5.343  1    42.05  ? 355 ILE B CG1 1 
ATOM   3925 C  CG2 . ILE B 2 185 ? -27.903 -0.94   -7.089  1    40.56  ? 355 ILE B CG2 1 
ATOM   3926 C  CD1 . ILE B 2 185 ? -29.002 -0.177  -4.267  1    37.58  ? 355 ILE B CD1 1 
ATOM   3927 N  N   . ALA B 2 186 ? -28.031 -4.656  -7.517  1    37.29  ? 356 ALA B N   1 
ATOM   3928 C  CA  . ALA B 2 186 ? -27.175 -5.479  -8.347  1    36.56  ? 356 ALA B CA  1 
ATOM   3929 C  C   . ALA B 2 186 ? -27.973 -6.05   -9.515  1    37.91  ? 356 ALA B C   1 
ATOM   3930 O  O   . ALA B 2 186 ? -27.498 -6.057  -10.646 1    45.23  ? 356 ALA B O   1 
ATOM   3931 C  CB  . ALA B 2 186 ? -26.552 -6.569  -7.515  1    33.77  ? 356 ALA B CB  1 
ATOM   3932 N  N   . ALA B 2 187 ? -29.195 -6.513  -9.235  1    35.51  ? 357 ALA B N   1 
ATOM   3933 C  CA  . ALA B 2 187 ? -30.05  -7.101  -10.242 1    33.28  ? 357 ALA B CA  1 
ATOM   3934 C  C   . ALA B 2 187 ? -30.408 -6.048  -11.281 1    36.68  ? 357 ALA B C   1 
ATOM   3935 O  O   . ALA B 2 187 ? -30.319 -6.302  -12.48  1    37.89  ? 357 ALA B O   1 
ATOM   3936 C  CB  . ALA B 2 187 ? -31.28  -7.696  -9.584  1    32.06  ? 357 ALA B CB  1 
ATOM   3937 N  N   . ALA B 2 188 ? -30.784 -4.848  -10.819 1    38.04  ? 358 ALA B N   1 
ATOM   3938 C  CA  . ALA B 2 188 ? -31.137 -3.78   -11.738 1    40.55  ? 358 ALA B CA  1 
ATOM   3939 C  C   . ALA B 2 188 ? -29.924 -3.373  -12.574 1    39.28  ? 358 ALA B C   1 
ATOM   3940 O  O   . ALA B 2 188 ? -30.027 -3.228  -13.788 1    39.43  ? 358 ALA B O   1 
ATOM   3941 C  CB  . ALA B 2 188 ? -31.698 -2.589  -10.99  1    40.17  ? 358 ALA B CB  1 
ATOM   3942 N  N   . ALA B 2 189 ? -28.779 -3.197  -11.905 1    38.08  ? 359 ALA B N   1 
ATOM   3943 C  CA  . ALA B 2 189 ? -27.532 -2.852  -12.573 1    39.81  ? 359 ALA B CA  1 
ATOM   3944 C  C   . ALA B 2 189 ? -27.187 -3.895  -13.635 1    42.34  ? 359 ALA B C   1 
ATOM   3945 O  O   . ALA B 2 189 ? -26.776 -3.546  -14.744 1    44.63  ? 359 ALA B O   1 
ATOM   3946 C  CB  . ALA B 2 189 ? -26.421 -2.747  -11.557 1    37.57  ? 359 ALA B CB  1 
ATOM   3947 N  N   . PHE B 2 190 ? -27.376 -5.178  -13.299 1    38.89  ? 360 PHE B N   1 
ATOM   3948 C  CA  . PHE B 2 190 ? -27.015 -6.232  -14.223 1    39.94  ? 360 PHE B CA  1 
ATOM   3949 C  C   . PHE B 2 190 ? -27.919 -6.215  -15.448 1    41.26  ? 360 PHE B C   1 
ATOM   3950 O  O   . PHE B 2 190 ? -27.448 -6.4    -16.558 1    47.03  ? 360 PHE B O   1 
ATOM   3951 C  CB  . PHE B 2 190 ? -27.05  -7.596  -13.544 1    40.71  ? 360 PHE B CB  1 
ATOM   3952 C  CG  . PHE B 2 190 ? -26.583 -8.701  -14.47  1    43.48  ? 360 PHE B CG  1 
ATOM   3953 C  CD1 . PHE B 2 190 ? -25.258 -8.775  -14.876 1    40.19  ? 360 PHE B CD1 1 
ATOM   3954 C  CD2 . PHE B 2 190 ? -27.475 -9.666  -14.923 1    44.33  ? 360 PHE B CD2 1 
ATOM   3955 C  CE1 . PHE B 2 190 ? -24.828 -9.815  -15.697 1    43.19  ? 360 PHE B CE1 1 
ATOM   3956 C  CE2 . PHE B 2 190 ? -27.04  -10.699 -15.749 1    48.04  ? 360 PHE B CE2 1 
ATOM   3957 C  CZ  . PHE B 2 190 ? -25.719 -10.774 -16.138 1    43.93  ? 360 PHE B CZ  1 
ATOM   3958 N  N   . HIS B 2 191 ? -29.222 -6.026  -15.264 1    41.34  ? 361 HIS B N   1 
ATOM   3959 C  CA  . HIS B 2 191 ? -30.132 -6.024  -16.4   1    39.94  ? 361 HIS B CA  1 
ATOM   3960 C  C   . HIS B 2 191 ? -29.88  -4.8    -17.28  1    41.33  ? 361 HIS B C   1 
ATOM   3961 O  O   . HIS B 2 191 ? -29.879 -4.896  -18.506 1    41.67  ? 361 HIS B O   1 
ATOM   3962 C  CB  . HIS B 2 191 ? -31.591 -6.01   -15.941 1    40.31  ? 361 HIS B CB  1 
ATOM   3963 C  CG  . HIS B 2 191 ? -32.517 -5.647  -17.061 1    42.35  ? 361 HIS B CG  1 
ATOM   3964 N  ND1 . HIS B 2 191 ? -32.924 -6.593  -17.985 1    42.16  ? 361 HIS B ND1 1 
ATOM   3965 C  CD2 . HIS B 2 191 ? -33.098 -4.483  -17.408 1    42.59  ? 361 HIS B CD2 1 
ATOM   3966 C  CE1 . HIS B 2 191 ? -33.755 -6.027  -18.842 1    46.95  ? 361 HIS B CE1 1 
ATOM   3967 N  NE2 . HIS B 2 191 ? -33.87  -4.748  -18.529 1    47.82  ? 361 HIS B NE2 1 
ATOM   3968 N  N   . LEU B 2 192 ? -29.629 -3.653  -16.639 1    39.42  ? 362 LEU B N   1 
ATOM   3969 C  CA  . LEU B 2 192 ? -29.448 -2.419  -17.37  1    41.8   ? 362 LEU B CA  1 
ATOM   3970 C  C   . LEU B 2 192 ? -28.172 -2.512  -18.203 1    42.06  ? 362 LEU B C   1 
ATOM   3971 O  O   . LEU B 2 192 ? -28.173 -2.08   -19.359 1    41.95  ? 362 LEU B O   1 
ATOM   3972 C  CB  . LEU B 2 192 ? -29.445 -1.276  -16.366 1    42.28  ? 362 LEU B CB  1 
ATOM   3973 C  CG  . LEU B 2 192 ? -29.367 0.129   -16.956 1    47.38  ? 362 LEU B CG  1 
ATOM   3974 C  CD1 . LEU B 2 192 ? -30.451 0.301   -18.007 1    47.76  ? 362 LEU B CD1 1 
ATOM   3975 C  CD2 . LEU B 2 192 ? -29.506 1.165   -15.838 1    47.53  ? 362 LEU B CD2 1 
ATOM   3976 N  N   . ALA B 2 193 ? -27.135 -3.147  -17.635 1    41.18  ? 363 ALA B N   1 
ATOM   3977 C  CA  . ALA B 2 193 ? -25.833 -3.265  -18.268 1    42.75  ? 363 ALA B CA  1 
ATOM   3978 C  C   . ALA B 2 193 ? -25.939 -4.198  -19.457 1    46.51  ? 363 ALA B C   1 
ATOM   3979 O  O   . ALA B 2 193 ? -25.42  -3.9    -20.542 1    50.66  ? 363 ALA B O   1 
ATOM   3980 C  CB  . ALA B 2 193 ? -24.809 -3.763  -17.306 1    38.72  ? 363 ALA B CB  1 
ATOM   3981 N  N   . LEU B 2 194 ? -26.665 -5.291  -19.234 1    43.58  ? 364 LEU B N   1 
ATOM   3982 C  CA  . LEU B 2 194 ? -26.859 -6.323  -20.232 1    44.45  ? 364 LEU B CA  1 
ATOM   3983 C  C   . LEU B 2 194 ? -27.671 -5.769  -21.397 1    48.5   ? 364 LEU B C   1 
ATOM   3984 O  O   . LEU B 2 194 ? -27.349 -6.007  -22.571 1    53.93  ? 364 LEU B O   1 
ATOM   3985 C  CB  . LEU B 2 194 ? -27.61  -7.424  -19.499 1    47.84  ? 364 LEU B CB  1 
ATOM   3986 C  CG  . LEU B 2 194 ? -27.793 -8.744  -20.234 1    60.29  ? 364 LEU B CG  1 
ATOM   3987 C  CD1 . LEU B 2 194 ? -26.454 -9.447  -20.532 1    56.3   ? 364 LEU B CD1 1 
ATOM   3988 C  CD2 . LEU B 2 194 ? -28.709 -9.597  -19.346 1    58.65  ? 364 LEU B CD2 1 
ATOM   3989 N  N   . TYR B 2 195 ? -28.738 -5.036  -21.061 1    48.02  ? 365 TYR B N   1 
ATOM   3990 C  CA  . TYR B 2 195 ? -29.625 -4.459  -22.055 1    47.87  ? 365 TYR B CA  1 
ATOM   3991 C  C   . TYR B 2 195 ? -28.853 -3.429  -22.883 1    48.09  ? 365 TYR B C   1 
ATOM   3992 O  O   . TYR B 2 195 ? -28.857 -3.489  -24.096 1    47.8   ? 365 TYR B O   1 
ATOM   3993 C  CB  . TYR B 2 195 ? -30.874 -3.898  -21.364 1    45.73  ? 365 TYR B CB  1 
ATOM   3994 C  CG  . TYR B 2 195 ? -31.914 -3.369  -22.338 1    51.19  ? 365 TYR B CG  1 
ATOM   3995 C  CD1 . TYR B 2 195 ? -32.545 -4.214  -23.255 1    55.59  ? 365 TYR B CD1 1 
ATOM   3996 C  CD2 . TYR B 2 195 ? -32.252 -2.026  -22.369 1    53.13  ? 365 TYR B CD2 1 
ATOM   3997 C  CE1 . TYR B 2 195 ? -33.496 -3.754  -24.154 1    56.2   ? 365 TYR B CE1 1 
ATOM   3998 C  CE2 . TYR B 2 195 ? -33.2   -1.547  -23.262 1    57.91  ? 365 TYR B CE2 1 
ATOM   3999 C  CZ  . TYR B 2 195 ? -33.817 -2.405  -24.16  1    60.56  ? 365 TYR B CZ  1 
ATOM   4000 O  OH  . TYR B 2 195 ? -34.75  -1.881  -25.016 1    67.95  ? 365 TYR B OH  1 
ATOM   4001 N  N   . THR B 2 196 ? -28.167 -2.497  -22.217 1    45.63  ? 366 THR B N   1 
ATOM   4002 C  CA  . THR B 2 196 ? -27.361 -1.492  -22.892 1    46.11  ? 366 THR B CA  1 
ATOM   4003 C  C   . THR B 2 196 ? -26.373 -2.123  -23.872 1    47.01  ? 366 THR B C   1 
ATOM   4004 O  O   . THR B 2 196 ? -26.269 -1.644  -24.978 1    48.3   ? 366 THR B O   1 
ATOM   4005 C  CB  . THR B 2 196 ? -26.6   -0.632  -21.884 1    43.98  ? 366 THR B CB  1 
ATOM   4006 O  OG1 . THR B 2 196 ? -27.499 -0.138  -20.894 1    45.09  ? 366 THR B OG1 1 
ATOM   4007 C  CG2 . THR B 2 196 ? -25.885 0.526   -22.554 1    41.29  ? 366 THR B CG2 1 
ATOM   4008 N  N   . VAL B 2 197 ? -25.647 -3.177  -23.473 1    48.16  ? 367 VAL B N   1 
ATOM   4009 C  CA  . VAL B 2 197 ? -24.511 -3.676  -24.236 1    48.8   ? 367 VAL B CA  1 
ATOM   4010 C  C   . VAL B 2 197 ? -24.956 -4.623  -25.352 1    52.24  ? 367 VAL B C   1 
ATOM   4011 O  O   . VAL B 2 197 ? -24.496 -4.485  -26.488 1    57.97  ? 367 VAL B O   1 
ATOM   4012 C  CB  . VAL B 2 197 ? -23.412 -4.293  -23.347 1    48.33  ? 367 VAL B CB  1 
ATOM   4013 C  CG1 . VAL B 2 197 ? -22.333 -5      -24.165 1    49.71  ? 367 VAL B CG1 1 
ATOM   4014 C  CG2 . VAL B 2 197 ? -22.773 -3.257  -22.43  1    43.99  ? 367 VAL B CG2 1 
ATOM   4015 N  N   . THR B 2 198 ? -25.852 -5.576  -25.038 1    51.47  ? 368 THR B N   1 
ATOM   4016 C  CA  . THR B 2 198 ? -26.171 -6.702  -25.92  1    48.52  ? 368 THR B CA  1 
ATOM   4017 C  C   . THR B 2 198 ? -27.647 -6.734  -26.281 1    51.84  ? 368 THR B C   1 
ATOM   4018 O  O   . THR B 2 198 ? -28.079 -7.674  -26.958 1    53     ? 368 THR B O   1 
ATOM   4019 C  CB  . THR B 2 198 ? -25.919 -8.019  -25.203 1    47.33  ? 368 THR B CB  1 
ATOM   4020 O  OG1 . THR B 2 198 ? -26.864 -8.07   -24.13  1    49.31  ? 368 THR B OG1 1 
ATOM   4021 C  CG2 . THR B 2 198 ? -24.507 -8.134  -24.662 1    45.92  ? 368 THR B CG2 1 
ATOM   4022 N  N   . GLY B 2 199 ? -28.437 -5.8    -25.723 1    53.6   ? 369 GLY B N   1 
ATOM   4023 C  CA  . GLY B 2 199 ? -29.88  -5.793  -25.927 1    55.03  ? 369 GLY B CA  1 
ATOM   4024 C  C   . GLY B 2 199 ? -30.638 -6.896  -25.179 1    58.7   ? 369 GLY B C   1 
ATOM   4025 O  O   . GLY B 2 199 ? -31.858 -6.938  -25.256 1    62.94  ? 369 GLY B O   1 
ATOM   4026 N  N   . GLN B 2 200 ? -29.945 -7.786  -24.458 1    57.16  ? 370 GLN B N   1 
ATOM   4027 C  CA  . GLN B 2 200 ? -30.626 -8.883  -23.797 1    60.25  ? 370 GLN B CA  1 
ATOM   4028 C  C   . GLN B 2 200 ? -31.147 -8.423  -22.432 1    60.38  ? 370 GLN B C   1 
ATOM   4029 O  O   . GLN B 2 200 ? -30.954 -7.265  -22.056 1    61.8   ? 370 GLN B O   1 
ATOM   4030 C  CB  . GLN B 2 200 ? -29.664 -10.043 -23.569 1    67.83  ? 370 GLN B CB  1 
ATOM   4031 C  CG  . GLN B 2 200 ? -28.967 -10.564 -24.815 1    74.73  ? 370 GLN B CG  1 
ATOM   4032 C  CD  . GLN B 2 200 ? -27.791 -11.421 -24.413 1    84.9   ? 370 GLN B CD  1 
ATOM   4033 O  OE1 . GLN B 2 200 ? -27.869 -12.649 -24.415 1    98.61  ? 370 GLN B OE1 1 
ATOM   4034 N  NE2 . GLN B 2 200 ? -26.712 -10.791 -23.977 1    86.23  ? 370 GLN B NE2 1 
ATOM   4035 N  N   . SER B 2 201 ? -31.769 -9.36   -21.698 1    53.03  ? 371 SER B N   1 
ATOM   4036 C  CA  . SER B 2 201 ? -32.573 -9.086  -20.522 1    49.7   ? 371 SER B CA  1 
ATOM   4037 C  C   . SER B 2 201 ? -32.165 -10.004 -19.393 1    47.95  ? 371 SER B C   1 
ATOM   4038 O  O   . SER B 2 201 ? -31.678 -11.1   -19.634 1    48.49  ? 371 SER B O   1 
ATOM   4039 C  CB  . SER B 2 201 ? -34.03  -9.336  -20.781 1    52.5   ? 371 SER B CB  1 
ATOM   4040 O  OG  . SER B 2 201 ? -34.539 -8.434  -21.749 1    56.99  ? 371 SER B OG  1 
ATOM   4041 N  N   . TRP B 2 202 ? -32.444 -9.539  -18.173 1    48.36  ? 372 TRP B N   1 
ATOM   4042 C  CA  . TRP B 2 202 ? -32.426 -10.339 -16.957 1    45.83  ? 372 TRP B CA  1 
ATOM   4043 C  C   . TRP B 2 202 ? -32.849 -11.758 -17.311 1    45.92  ? 372 TRP B C   1 
ATOM   4044 O  O   . TRP B 2 202 ? -33.975 -11.972 -17.735 1    45.65  ? 372 TRP B O   1 
ATOM   4045 C  CB  . TRP B 2 202 ? -33.437 -9.745  -15.964 1    45.25  ? 372 TRP B CB  1 
ATOM   4046 C  CG  . TRP B 2 202 ? -33.455 -10.395 -14.601 1    44.66  ? 372 TRP B CG  1 
ATOM   4047 C  CD1 . TRP B 2 202 ? -34.497 -11.09  -14.068 1    44.85  ? 372 TRP B CD1 1 
ATOM   4048 C  CD2 . TRP B 2 202 ? -32.42  -10.395 -13.596 1    42.49  ? 372 TRP B CD2 1 
ATOM   4049 N  NE1 . TRP B 2 202 ? -34.199 -11.507 -12.803 1    44.4   ? 372 TRP B NE1 1 
ATOM   4050 C  CE2 . TRP B 2 202 ? -32.942 -11.089 -12.481 1    42.14  ? 372 TRP B CE2 1 
ATOM   4051 C  CE3 . TRP B 2 202 ? -31.115 -9.873  -13.517 1    43.38  ? 372 TRP B CE3 1 
ATOM   4052 C  CZ2 . TRP B 2 202 ? -32.207 -11.279 -11.312 1    40.88  ? 372 TRP B CZ2 1 
ATOM   4053 C  CZ3 . TRP B 2 202 ? -30.379 -10.06  -12.355 1    41.59  ? 372 TRP B CZ3 1 
ATOM   4054 C  CH2 . TRP B 2 202 ? -30.921 -10.76  -11.271 1    40.76  ? 372 TRP B CH2 1 
ATOM   4055 N  N   . PRO B 2 203 ? -31.958 -12.752 -17.185 1    42.68  ? 373 PRO B N   1 
ATOM   4056 C  CA  . PRO B 2 203 ? -32.271 -14.115 -17.612 1    43.11  ? 373 PRO B CA  1 
ATOM   4057 C  C   . PRO B 2 203 ? -33.077 -14.946 -16.625 1    44.36  ? 373 PRO B C   1 
ATOM   4058 O  O   . PRO B 2 203 ? -32.961 -14.827 -15.4   1    44.14  ? 373 PRO B O   1 
ATOM   4059 C  CB  . PRO B 2 203 ? -30.885 -14.737 -17.796 1    43.26  ? 373 PRO B CB  1 
ATOM   4060 C  CG  . PRO B 2 203 ? -30.046 -14.031 -16.713 1    46.86  ? 373 PRO B CG  1 
ATOM   4061 C  CD  . PRO B 2 203 ? -30.581 -12.589 -16.679 1    44.53  ? 373 PRO B CD  1 
ATOM   4062 N  N   . GLU B 2 204 ? -33.842 -15.859 -17.206 1    46.87  ? 374 GLU B N   1 
ATOM   4063 C  CA  . GLU B 2 204 ? -34.672 -16.774 -16.457 1    48.54  ? 374 GLU B CA  1 
ATOM   4064 C  C   . GLU B 2 204 ? -33.858 -17.508 -15.39  1    45.91  ? 374 GLU B C   1 
ATOM   4065 O  O   . GLU B 2 204 ? -34.373 -17.786 -14.307 1    44.16  ? 374 GLU B O   1 
ATOM   4066 C  CB  . GLU B 2 204 ? -35.288 -17.72  -17.482 1    56.34  ? 374 GLU B CB  1 
ATOM   4067 C  CG  . GLU B 2 204 ? -36.659 -18.226 -17.021 1    69.86  ? 374 GLU B CG  1 
ATOM   4068 C  CD  . GLU B 2 204 ? -36.51  -19.473 -16.163 1    72.52  ? 374 GLU B CD  1 
ATOM   4069 O  OE1 . GLU B 2 204 ? -37.253 -19.562 -15.159 1    77.91  ? 374 GLU B OE1 1 
ATOM   4070 O  OE2 . GLU B 2 204 ? -35.643 -20.329 -16.501 1    66.71  ? 374 GLU B OE2 1 
ATOM   4071 N  N   . SER B 2 205 ? -32.596 -17.837 -15.706 1    42.57  ? 375 SER B N   1 
ATOM   4072 C  CA  . SER B 2 205 ? -31.739 -18.534 -14.767 1    43.99  ? 375 SER B CA  1 
ATOM   4073 C  C   . SER B 2 205 ? -31.572 -17.712 -13.479 1    43.95  ? 375 SER B C   1 
ATOM   4074 O  O   . SER B 2 205 ? -31.437 -18.28  -12.387 1    46.04  ? 375 SER B O   1 
ATOM   4075 C  CB  . SER B 2 205 ? -30.431 -18.945 -15.398 1    43.48  ? 375 SER B CB  1 
ATOM   4076 O  OG  . SER B 2 205 ? -29.557 -17.833 -15.585 1    50.95  ? 375 SER B OG  1 
ATOM   4077 N  N   . LEU B 2 206 ? -31.615 -16.376 -13.6   1    41.97  ? 376 LEU B N   1 
ATOM   4078 C  CA  . LEU B 2 206 ? -31.422 -15.511 -12.443 1    41.24  ? 376 LEU B CA  1 
ATOM   4079 C  C   . LEU B 2 206 ? -32.753 -15.276 -11.748 1    41.34  ? 376 LEU B C   1 
ATOM   4080 O  O   . LEU B 2 206 ? -32.731 -15.008 -10.55  1    40.03  ? 376 LEU B O   1 
ATOM   4081 C  CB  . LEU B 2 206 ? -30.696 -14.215 -12.764 1    37.47  ? 376 LEU B CB  1 
ATOM   4082 C  CG  . LEU B 2 206 ? -29.186 -14.365 -12.942 1    39.31  ? 376 LEU B CG  1 
ATOM   4083 C  CD1 . LEU B 2 206 ? -28.531 -13.096 -13.464 1    37.65  ? 376 LEU B CD1 1 
ATOM   4084 C  CD2 . LEU B 2 206 ? -28.544 -14.799 -11.649 1    38.58  ? 376 LEU B CD2 1 
ATOM   4085 N  N   . VAL B 2 207 ? -33.861 -15.414 -12.502 1    40.08  ? 377 VAL B N   1 
ATOM   4086 C  CA  . VAL B 2 207 ? -35.179 -15.538 -11.899 1    42.22  ? 377 VAL B CA  1 
ATOM   4087 C  C   . VAL B 2 207 ? -35.195 -16.779 -10.992 1    43.86  ? 377 VAL B C   1 
ATOM   4088 O  O   . VAL B 2 207 ? -35.639 -16.699 -9.859  1    42.67  ? 377 VAL B O   1 
ATOM   4089 C  CB  . VAL B 2 207 ? -36.338 -15.529 -12.925 1    44.27  ? 377 VAL B CB  1 
ATOM   4090 C  CG1 . VAL B 2 207 ? -37.719 -15.685 -12.271 1    40.53  ? 377 VAL B CG1 1 
ATOM   4091 C  CG2 . VAL B 2 207 ? -36.292 -14.286 -13.809 1    43.22  ? 377 VAL B CG2 1 
ATOM   4092 N  N   . GLN B 2 208 ? -34.645 -17.886 -11.462 1    44.1   ? 378 GLN B N   1 
ATOM   4093 C  CA  . GLN B 2 208 ? -34.634 -19.131 -10.661 1    43.45  ? 378 GLN B CA  1 
ATOM   4094 C  C   . GLN B 2 208 ? -33.819 -18.949 -9.374  1    42.51  ? 378 GLN B C   1 
ATOM   4095 O  O   . GLN B 2 208 ? -34.225 -19.5   -8.346  1    43.22  ? 378 GLN B O   1 
ATOM   4096 C  CB  . GLN B 2 208 ? -34.075 -20.249 -11.533 1    43.05  ? 378 GLN B CB  1 
ATOM   4097 C  CG  . GLN B 2 208 ? -35.026 -20.724 -12.622 1    52.19  ? 378 GLN B CG  1 
ATOM   4098 C  CD  . GLN B 2 208 ? -36.299 -21.32  -12.068 1    59.08  ? 378 GLN B CD  1 
ATOM   4099 O  OE1 . GLN B 2 208 ? -37.404 -21.019 -12.527 1    67.29  ? 378 GLN B OE1 1 
ATOM   4100 N  NE2 . GLN B 2 208 ? -36.155 -22.172 -11.065 1    54.27  ? 378 GLN B NE2 1 
ATOM   4101 N  N   . LYS B 2 209 ? -32.734 -18.187 -9.419  1    42.4   ? 379 LYS B N   1 
ATOM   4102 C  CA  . LYS B 2 209 ? -31.835 -18.055 -8.249  1    44.98  ? 379 LYS B CA  1 
ATOM   4103 C  C   . LYS B 2 209 ? -32.3   -16.971 -7.279  1    45.25  ? 379 LYS B C   1 
ATOM   4104 O  O   . LYS B 2 209 ? -32.194 -17.198 -6.066  1    42.78  ? 379 LYS B O   1 
ATOM   4105 C  CB  . LYS B 2 209 ? -30.454 -17.672 -8.785  1    51.96  ? 379 LYS B CB  1 
ATOM   4106 C  CG  . LYS B 2 209 ? -29.326 -17.545 -7.769  1    63.3   ? 379 LYS B CG  1 
ATOM   4107 C  CD  . LYS B 2 209 ? -27.976 -17.209 -8.39   1    61.21  ? 379 LYS B CD  1 
ATOM   4108 C  CE  . LYS B 2 209 ? -26.867 -17.059 -7.4    1    48.77  ? 379 LYS B CE  1 
ATOM   4109 N  NZ  . LYS B 2 209 ? -25.589 -16.737 -8.036  1    48.28  ? 379 LYS B NZ  1 
ATOM   4110 N  N   . THR B 2 210 ? -32.821 -15.864 -7.789  1    41.18  ? 380 THR B N   1 
ATOM   4111 C  CA  . THR B 2 210 ? -33.142 -14.714 -6.93   1    39.61  ? 380 THR B CA  1 
ATOM   4112 C  C   . THR B 2 210 ? -34.607 -14.646 -6.606  1    40.18  ? 380 THR B C   1 
ATOM   4113 O  O   . THR B 2 210 ? -34.929 -14.128 -5.53   1    44.25  ? 380 THR B O   1 
ATOM   4114 C  CB  . THR B 2 210 ? -32.685 -13.465 -7.683  1    39     ? 380 THR B CB  1 
ATOM   4115 O  OG1 . THR B 2 210 ? -33.492 -13.394 -8.851  1    40.76  ? 380 THR B OG1 1 
ATOM   4116 C  CG2 . THR B 2 210 ? -31.22  -13.522 -8.07   1    35.59  ? 380 THR B CG2 1 
ATOM   4117 N  N   . GLY B 2 211 ? -35.468 -15.129 -7.493  1    39.15  ? 381 GLY B N   1 
ATOM   4118 C  CA  . GLY B 2 211 ? -36.916 -14.958 -7.3    1    39.24  ? 381 GLY B CA  1 
ATOM   4119 C  C   . GLY B 2 211 ? -37.306 -13.579 -7.765  1    41.86  ? 381 GLY B C   1 
ATOM   4120 O  O   . GLY B 2 211 ? -38.459 -13.184 -7.568  1    43.64  ? 381 GLY B O   1 
ATOM   4121 N  N   . TYR B 2 212 ? -36.357 -12.871 -8.364  1    41.44  ? 382 TYR B N   1 
ATOM   4122 C  CA  . TYR B 2 212 ? -36.603 -11.491 -8.833  1    40.72  ? 382 TYR B CA  1 
ATOM   4123 C  C   . TYR B 2 212 ? -36.959 -11.517 -10.302 1    46.25  ? 382 TYR B C   1 
ATOM   4124 O  O   . TYR B 2 212 ? -36.291 -12.215 -11.073 1    48.08  ? 382 TYR B O   1 
ATOM   4125 C  CB  . TYR B 2 212 ? -35.361 -10.618 -8.645  1    39.55  ? 382 TYR B CB  1 
ATOM   4126 C  CG  . TYR B 2 212 ? -34.861 -10.329 -7.24   1    38.23  ? 382 TYR B CG  1 
ATOM   4127 C  CD1 . TYR B 2 212 ? -35.692 -10.432 -6.134  1    35.58  ? 382 TYR B CD1 1 
ATOM   4128 C  CD2 . TYR B 2 212 ? -33.548 -9.928  -7.032  1    33.85  ? 382 TYR B CD2 1 
ATOM   4129 C  CE1 . TYR B 2 212 ? -35.227 -10.153 -4.861  1    33.88  ? 382 TYR B CE1 1 
ATOM   4130 C  CE2 . TYR B 2 212 ? -33.071 -9.652  -5.765  1    33.98  ? 382 TYR B CE2 1 
ATOM   4131 C  CZ  . TYR B 2 212 ? -33.914 -9.763  -4.677  1    38     ? 382 TYR B CZ  1 
ATOM   4132 O  OH  . TYR B 2 212 ? -33.443 -9.484  -3.432  1    39.77  ? 382 TYR B OH  1 
ATOM   4133 N  N   . THR B 2 213 ? -38.012 -10.802 -10.675 1    46.05  ? 383 THR B N   1 
ATOM   4134 C  CA  . THR B 2 213 ? -38.412 -10.653 -12.066 1    47.61  ? 383 THR B CA  1 
ATOM   4135 C  C   . THR B 2 213 ? -38.274 -9.183  -12.442 1    49.9   ? 383 THR B C   1 
ATOM   4136 O  O   . THR B 2 213 ? -38.178 -8.312  -11.57  1    46.88  ? 383 THR B O   1 
ATOM   4137 C  CB  . THR B 2 213 ? -39.864 -11.09  -12.297 1    49.59  ? 383 THR B CB  1 
ATOM   4138 O  OG1 . THR B 2 213 ? -40.67  -10.208 -11.518 1    51.29  ? 383 THR B OG1 1 
ATOM   4139 C  CG2 . THR B 2 213 ? -40.17  -12.532 -11.923 1    46.44  ? 383 THR B CG2 1 
ATOM   4140 N  N   . LEU B 2 214 ? -38.349 -8.913  -13.75  1    50.53  ? 384 LEU B N   1 
ATOM   4141 C  CA  . LEU B 2 214 ? -38.34  -7.533  -14.2   1    51.49  ? 384 LEU B CA  1 
ATOM   4142 C  C   . LEU B 2 214 ? -39.433 -6.754  -13.496 1    54.25  ? 384 LEU B C   1 
ATOM   4143 O  O   . LEU B 2 214 ? -39.286 -5.551  -13.319 1    59     ? 384 LEU B O   1 
ATOM   4144 C  CB  . LEU B 2 214 ? -38.498 -7.432  -15.71  1    50.7   ? 384 LEU B CB  1 
ATOM   4145 C  CG  . LEU B 2 214 ? -37.23  -7.726  -16.505 1    47.75  ? 384 LEU B CG  1 
ATOM   4146 C  CD1 . LEU B 2 214 ? -37.501 -7.7    -18.005 1    45.6   ? 384 LEU B CD1 1 
ATOM   4147 C  CD2 . LEU B 2 214 ? -36.139 -6.754  -16.079 1    44.23  ? 384 LEU B CD2 1 
ATOM   4148 N  N   . GLU B 2 215 ? -40.526 -7.443  -13.146 1    58.45  ? 385 GLU B N   1 
ATOM   4149 C  CA  . GLU B 2 215 ? -41.638 -6.863  -12.401 1    60.57  ? 385 GLU B CA  1 
ATOM   4150 C  C   . GLU B 2 215 ? -41.143 -6.39   -11.027 1    54.18  ? 385 GLU B C   1 
ATOM   4151 O  O   . GLU B 2 215 ? -41.287 -5.227  -10.692 1    54.49  ? 385 GLU B O   1 
ATOM   4152 C  CB  . GLU B 2 215 ? -42.797 -7.864  -12.354 1    66.82  ? 385 GLU B CB  1 
ATOM   4153 C  CG  . GLU B 2 215 ? -44.08  -7.355  -11.697 1    82.17  ? 385 GLU B CG  1 
ATOM   4154 C  CD  . GLU B 2 215 ? -45.177 -6.925  -12.654 1    108.09 ? 385 GLU B CD  1 
ATOM   4155 O  OE1 . GLU B 2 215 ? -44.881 -6.198  -13.637 1    118.05 ? 385 GLU B OE1 1 
ATOM   4156 O  OE2 . GLU B 2 215 ? -46.343 -7.313  -12.402 1    113.3  ? 385 GLU B OE2 1 
ATOM   4157 N  N   . THR B 2 216 ? -40.491 -7.256  -10.261 1    49.15  ? 386 THR B N   1 
ATOM   4158 C  CA  . THR B 2 216 ? -40.06  -6.861  -8.925  1    51.1   ? 386 THR B CA  1 
ATOM   4159 C  C   . THR B 2 216 ? -38.917 -5.832  -8.987  1    54.82  ? 386 THR B C   1 
ATOM   4160 O  O   . THR B 2 216 ? -38.82  -4.982  -8.101  1    58.69  ? 386 THR B O   1 
ATOM   4161 C  CB  . THR B 2 216 ? -39.753 -8.088  -8.056  1    47.17  ? 386 THR B CB  1 
ATOM   4162 O  OG1 . THR B 2 216 ? -38.537 -8.672  -8.493  1    44.87  ? 386 THR B OG1 1 
ATOM   4163 C  CG2 . THR B 2 216 ? -40.805 -9.188  -8.125  1    47.86  ? 386 THR B CG2 1 
ATOM   4164 N  N   . LEU B 2 217 ? -38.103 -5.847  -10.06  1    50.96  ? 387 LEU B N   1 
ATOM   4165 C  CA  . LEU B 2 217 ? -36.969 -4.936  -10.199 1    47.14  ? 387 LEU B CA  1 
ATOM   4166 C  C   . LEU B 2 217 ? -37.372 -3.567  -10.744 1    49.47  ? 387 LEU B C   1 
ATOM   4167 O  O   . LEU B 2 217 ? -36.552 -2.653  -10.704 1    47.37  ? 387 LEU B O   1 
ATOM   4168 C  CB  . LEU B 2 217 ? -35.916 -5.538  -11.127 1    42.55  ? 387 LEU B CB  1 
ATOM   4169 C  CG  . LEU B 2 217 ? -35.34  -6.887  -10.687 1    41.93  ? 387 LEU B CG  1 
ATOM   4170 C  CD1 . LEU B 2 217 ? -34.5   -7.49   -11.81  1    41.49  ? 387 LEU B CD1 1 
ATOM   4171 C  CD2 . LEU B 2 217 ? -34.56  -6.769  -9.369  1    35.72  ? 387 LEU B CD2 1 
ATOM   4172 N  N   . LYS B 2 218 ? -38.603 -3.424  -11.251 1    51.36  ? 388 LYS B N   1 
ATOM   4173 C  CA  . LYS B 2 218 ? -38.988 -2.29   -12.092 1    56.25  ? 388 LYS B CA  1 
ATOM   4174 C  C   . LYS B 2 218 ? -38.733 -0.959  -11.373 1    58.49  ? 388 LYS B C   1 
ATOM   4175 O  O   . LYS B 2 218 ? -38.102 -0.051  -11.93  1    59.68  ? 388 LYS B O   1 
ATOM   4176 C  CB  . LYS B 2 218 ? -40.421 -2.439  -12.628 1    54.18  ? 388 LYS B CB  1 
ATOM   4177 C  CG  . LYS B 2 218 ? -41.014 -1.232  -13.334 1    60.38  ? 388 LYS B CG  1 
ATOM   4178 C  CD  . LYS B 2 218 ? -42.263 -1.529  -14.157 1    64.28  ? 388 LYS B CD  1 
ATOM   4179 C  CE  . LYS B 2 218 ? -43.042 -0.328  -14.621 1    72.12  ? 388 LYS B CE  1 
ATOM   4180 N  NZ  . LYS B 2 218 ? -43.904 -0.605  -15.786 1    73.34  ? 388 LYS B NZ  1 
ATOM   4181 N  N   . PRO B 2 219 ? -39.209 -0.78   -10.118 1    55.42  ? 389 PRO B N   1 
ATOM   4182 C  CA  . PRO B 2 219 ? -38.982 0.49    -9.42   1    53.93  ? 389 PRO B CA  1 
ATOM   4183 C  C   . PRO B 2 219 ? -37.501 0.918   -9.374  1    50.59  ? 389 PRO B C   1 
ATOM   4184 O  O   . PRO B 2 219 ? -37.149 2.036   -9.756  1    47.95  ? 389 PRO B O   1 
ATOM   4185 C  CB  . PRO B 2 219 ? -39.602 0.224   -8.047  1    49.79  ? 389 PRO B CB  1 
ATOM   4186 C  CG  . PRO B 2 219 ? -40.588 -0.889  -8.286  1    49.3   ? 389 PRO B CG  1 
ATOM   4187 C  CD  . PRO B 2 219 ? -39.943 -1.775  -9.322  1    50.08  ? 389 PRO B CD  1 
ATOM   4188 N  N   . CYS B 2 220 ? -36.621 0.008   -8.949  1    47.55  ? 390 CYS B N   1 
ATOM   4189 C  CA  . CYS B 2 220 ? -35.184 0.267   -8.904  1    48.11  ? 390 CYS B CA  1 
ATOM   4190 C  C   . CYS B 2 220 ? -34.617 0.502   -10.317 1    49.86  ? 390 CYS B C   1 
ATOM   4191 O  O   . CYS B 2 220 ? -33.786 1.375   -10.553 1    50.51  ? 390 CYS B O   1 
ATOM   4192 C  CB  . CYS B 2 220 ? -34.488 -0.903  -8.222  1    44.97  ? 390 CYS B CB  1 
ATOM   4193 S  SG  . CYS B 2 220 ? -32.722 -0.657  -7.961  1    45.41  ? 390 CYS B SG  1 
ATOM   4194 N  N   . LEU B 2 221 ? -35.111 -0.269  -11.279 1    46.12  ? 391 LEU B N   1 
ATOM   4195 C  CA  . LEU B 2 221 ? -34.713 -0.129  -12.658 1    47.73  ? 391 LEU B CA  1 
ATOM   4196 C  C   . LEU B 2 221 ? -35.022 1.273   -13.169 1    53.19  ? 391 LEU B C   1 
ATOM   4197 O  O   . LEU B 2 221 ? -34.187 1.874   -13.841 1    55.65  ? 391 LEU B O   1 
ATOM   4198 C  CB  . LEU B 2 221 ? -35.488 -1.193  -13.43  1    52.98  ? 391 LEU B CB  1 
ATOM   4199 C  CG  . LEU B 2 221 ? -35.18  -2.657  -13.118 1    57.7   ? 391 LEU B CG  1 
ATOM   4200 C  CD1 . LEU B 2 221 ? -36.118 -3.622  -13.844 1    52.33  ? 391 LEU B CD1 1 
ATOM   4201 C  CD2 . LEU B 2 221 ? -33.73  -2.876  -13.535 1    57.12  ? 391 LEU B CD2 1 
ATOM   4202 N  N   . LEU B 2 222 ? -36.23  1.789   -12.889 1    53.97  ? 392 LEU B N   1 
ATOM   4203 C  CA  . LEU B 2 222 ? -36.582 3.13    -13.335 1    54.97  ? 392 LEU B CA  1 
ATOM   4204 C  C   . LEU B 2 222 ? -35.657 4.178   -12.702 1    55.04  ? 392 LEU B C   1 
ATOM   4205 O  O   . LEU B 2 222 ? -35.248 5.123   -13.378 1    55.61  ? 392 LEU B O   1 
ATOM   4206 C  CB  . LEU B 2 222 ? -38.045 3.39    -12.999 1    54.43  ? 392 LEU B CB  1 
ATOM   4207 C  CG  . LEU B 2 222 ? -39.065 2.564   -13.788 1    55.63  ? 392 LEU B CG  1 
ATOM   4208 C  CD1 . LEU B 2 222 ? -40.502 2.933   -13.39  1    52.06  ? 392 LEU B CD1 1 
ATOM   4209 C  CD2 . LEU B 2 222 ? -38.85  2.737   -15.285 1    51.86  ? 392 LEU B CD2 1 
ATOM   4210 N  N   . ASP B 2 223 ? -35.336 4.008   -11.408 1    48.96  ? 393 ASP B N   1 
ATOM   4211 C  CA  . ASP B 2 223 ? -34.436 4.925   -10.73  1    50.14  ? 393 ASP B CA  1 
ATOM   4212 C  C   . ASP B 2 223 ? -33.041 4.884   -11.358 1    50.93  ? 393 ASP B C   1 
ATOM   4213 O  O   . ASP B 2 223 ? -32.438 5.927   -11.61  1    51.08  ? 393 ASP B O   1 
ATOM   4214 C  CB  . ASP B 2 223 ? -34.382 4.665   -9.23   1    48.36  ? 393 ASP B CB  1 
ATOM   4215 C  CG  . ASP B 2 223 ? -35.52  5.262   -8.407  1    49.93  ? 393 ASP B CG  1 
ATOM   4216 O  OD1 . ASP B 2 223 ? -36.22  6.142   -8.925  1    52.25  ? 393 ASP B OD1 1 
ATOM   4217 O  OD2 . ASP B 2 223 ? -35.728 4.797   -7.259  1    54.99  ? 393 ASP B OD2 1 
ATOM   4218 N  N   . LEU B 2 224 ? -32.519 3.668   -11.573 1    47.94  ? 394 LEU B N   1 
ATOM   4219 C  CA  . LEU B 2 224 ? -31.143 3.468   -12.011 1    46.02  ? 394 LEU B CA  1 
ATOM   4220 C  C   . LEU B 2 224 ? -30.968 3.96    -13.455 1    45.7   ? 394 LEU B C   1 
ATOM   4221 O  O   . LEU B 2 224 ? -29.915 4.479   -13.828 1    42.42  ? 394 LEU B O   1 
ATOM   4222 C  CB  . LEU B 2 224 ? -30.766 2       -11.859 1    42.64  ? 394 LEU B CB  1 
ATOM   4223 C  CG  . LEU B 2 224 ? -29.262 1.712   -11.829 1    43.28  ? 394 LEU B CG  1 
ATOM   4224 C  CD1 . LEU B 2 224 ? -28.572 2.409   -10.653 1    40.39  ? 394 LEU B CD1 1 
ATOM   4225 C  CD2 . LEU B 2 224 ? -28.96  0.23    -11.823 1    37.43  ? 394 LEU B CD2 1 
ATOM   4226 N  N   . HIS B 2 225 ? -32.032 3.82    -14.243 1    42.92  ? 395 HIS B N   1 
ATOM   4227 C  CA  . HIS B 2 225 ? -32.036 4.276   -15.614 1    48.71  ? 395 HIS B CA  1 
ATOM   4228 C  C   . HIS B 2 225 ? -31.927 5.808   -15.625 1    53.65  ? 395 HIS B C   1 
ATOM   4229 O  O   . HIS B 2 225 ? -31.2   6.367   -16.451 1    57.05  ? 395 HIS B O   1 
ATOM   4230 C  CB  . HIS B 2 225 ? -33.271 3.704   -16.326 1    46.61  ? 395 HIS B CB  1 
ATOM   4231 C  CG  . HIS B 2 225 ? -33.458 4.112   -17.736 1    48.62  ? 395 HIS B CG  1 
ATOM   4232 N  ND1 . HIS B 2 225 ? -32.406 4.086   -18.623 1    51.59  ? 395 HIS B ND1 1 
ATOM   4233 C  CD2 . HIS B 2 225 ? -34.527 4.545   -18.433 1    51.85  ? 395 HIS B CD2 1 
ATOM   4234 C  CE1 . HIS B 2 225 ? -32.824 4.481   -19.824 1    52.98  ? 395 HIS B CE1 1 
ATOM   4235 N  NE2 . HIS B 2 225 ? -34.106 4.779   -19.725 1    54.6   ? 395 HIS B NE2 1 
ATOM   4236 N  N   . GLN B 2 226 ? -32.676 6.485   -14.737 1    52.15  ? 396 GLN B N   1 
ATOM   4237 C  CA  . GLN B 2 226 ? -32.611 7.931   -14.629 1    54.47  ? 396 GLN B CA  1 
ATOM   4238 C  C   . GLN B 2 226 ? -31.204 8.339   -14.182 1    56.05  ? 396 GLN B C   1 
ATOM   4239 O  O   . GLN B 2 226 ? -30.614 9.28    -14.725 1    63.3   ? 396 GLN B O   1 
ATOM   4240 C  CB  . GLN B 2 226 ? -33.711 8.525   -13.746 1    56.18  ? 396 GLN B CB  1 
ATOM   4241 C  CG  . GLN B 2 226 ? -35.102 8.624   -14.375 1    68.02  ? 396 GLN B CG  1 
ATOM   4242 C  CD  . GLN B 2 226 ? -35.168 9.211   -15.786 1    83.78  ? 396 GLN B CD  1 
ATOM   4243 O  OE1 . GLN B 2 226 ? -35.704 8.581   -16.717 1    78.53  ? 396 GLN B OE1 1 
ATOM   4244 N  NE2 . GLN B 2 226 ? -34.648 10.425  -15.983 1    80.29  ? 396 GLN B NE2 1 
ATOM   4245 N  N   . THR B 2 227 ? -30.653 7.62    -13.197 1    50.47  ? 397 THR B N   1 
ATOM   4246 C  CA  . THR B 2 227 ? -29.329 7.935   -12.702 1    47.52  ? 397 THR B CA  1 
ATOM   4247 C  C   . THR B 2 227 ? -28.317 7.832   -13.838 1    46.76  ? 397 THR B C   1 
ATOM   4248 O  O   . THR B 2 227 ? -27.469 8.691   -13.987 1    47.15  ? 397 THR B O   1 
ATOM   4249 C  CB  . THR B 2 227 ? -28.971 7.032   -11.526 1    45.29  ? 397 THR B CB  1 
ATOM   4250 O  OG1 . THR B 2 227 ? -29.877 7.437   -10.503 1    46.82  ? 397 THR B OG1 1 
ATOM   4251 C  CG2 . THR B 2 227 ? -27.541 7.225   -11.047 1    41.53  ? 397 THR B CG2 1 
ATOM   4252 N  N   . TYR B 2 228 ? -28.41  6.769   -14.634 1    49.79  ? 398 TYR B N   1 
ATOM   4253 C  CA  . TYR B 2 228 ? -27.536 6.568   -15.786 1    48.14  ? 398 TYR B CA  1 
ATOM   4254 C  C   . TYR B 2 228 ? -27.669 7.729   -16.785 1    52.83  ? 398 TYR B C   1 
ATOM   4255 O  O   . TYR B 2 228 ? -26.655 8.297   -17.179 1    51.52  ? 398 TYR B O   1 
ATOM   4256 C  CB  . TYR B 2 228 ? -27.863 5.205   -16.381 1    44.72  ? 398 TYR B CB  1 
ATOM   4257 C  CG  . TYR B 2 228 ? -26.905 4.658   -17.42  1    47.21  ? 398 TYR B CG  1 
ATOM   4258 C  CD1 . TYR B 2 228 ? -25.635 5.2     -17.607 1    50.08  ? 398 TYR B CD1 1 
ATOM   4259 C  CD2 . TYR B 2 228 ? -27.252 3.536   -18.164 1    48.81  ? 398 TYR B CD2 1 
ATOM   4260 C  CE1 . TYR B 2 228 ? -24.754 4.652   -18.532 1    53.7   ? 398 TYR B CE1 1 
ATOM   4261 C  CE2 . TYR B 2 228 ? -26.389 2.999   -19.108 1    51.12  ? 398 TYR B CE2 1 
ATOM   4262 C  CZ  . TYR B 2 228 ? -25.131 3.552   -19.285 1    53.41  ? 398 TYR B CZ  1 
ATOM   4263 O  OH  . TYR B 2 228 ? -24.276 3.002   -20.198 1    53.85  ? 398 TYR B OH  1 
ATOM   4264 N  N   . LEU B 2 229 ? -28.911 8.107   -17.158 1    52.87  ? 399 LEU B N   1 
ATOM   4265 C  CA  . LEU B 2 229 ? -29.146 9.21    -18.083 1    58.34  ? 399 LEU B CA  1 
ATOM   4266 C  C   . LEU B 2 229 ? -28.573 10.538  -17.569 1    61.13  ? 399 LEU B C   1 
ATOM   4267 O  O   . LEU B 2 229 ? -28.059 11.335  -18.359 1    60.24  ? 399 LEU B O   1 
ATOM   4268 C  CB  . LEU B 2 229 ? -30.635 9.358   -18.388 1    58.18  ? 399 LEU B CB  1 
ATOM   4269 C  CG  . LEU B 2 229 ? -31.27  8.35    -19.358 1    58.87  ? 399 LEU B CG  1 
ATOM   4270 C  CD1 . LEU B 2 229 ? -32.79  8.485   -19.31  1    57.23  ? 399 LEU B CD1 1 
ATOM   4271 C  CD2 . LEU B 2 229 ? -30.771 8.525   -20.788 1    54.96  ? 399 LEU B CD2 1 
ATOM   4272 N  N   . ARG B 2 230 ? -28.699 10.787  -16.256 1    59.3   ? 400 ARG B N   1 
ATOM   4273 C  CA  . ARG B 2 230 ? -28.393 12.101  -15.707 1    67.11  ? 400 ARG B CA  1 
ATOM   4274 C  C   . ARG B 2 230 ? -26.952 12.188  -15.21  1    63.48  ? 400 ARG B C   1 
ATOM   4275 O  O   . ARG B 2 230 ? -26.574 13.24   -14.693 1    62.34  ? 400 ARG B O   1 
ATOM   4276 C  CB  . ARG B 2 230 ? -29.331 12.465  -14.547 1    72.23  ? 400 ARG B CB  1 
ATOM   4277 C  CG  . ARG B 2 230 ? -30.755 12.785  -14.981 1    83.02  ? 400 ARG B CG  1 
ATOM   4278 C  CD  . ARG B 2 230 ? -31.687 13.02   -13.8   1    90.54  ? 400 ARG B CD  1 
ATOM   4279 N  NE  . ARG B 2 230 ? -33.064 13.3    -14.232 1    102.52 ? 400 ARG B NE  1 
ATOM   4280 C  CZ  . ARG B 2 230 ? -34.175 12.772  -13.721 1    98.57  ? 400 ARG B CZ  1 
ATOM   4281 N  NH1 . ARG B 2 230 ? -34.116 11.973  -12.66  1    91.45  ? 400 ARG B NH1 1 
ATOM   4282 N  NH2 . ARG B 2 230 ? -35.335 13.062  -14.284 1    89.99  ? 400 ARG B NH2 1 
ATOM   4283 N  N   . ALA B 2 231 ? -26.179 11.097  -15.362 1    57.95  ? 401 ALA B N   1 
ATOM   4284 C  CA  . ALA B 2 231 ? -24.88  10.937  -14.715 1    53.52  ? 401 ALA B CA  1 
ATOM   4285 C  C   . ALA B 2 231 ? -23.882 11.99   -15.202 1    56.26  ? 401 ALA B C   1 
ATOM   4286 O  O   . ALA B 2 231 ? -23.071 12.476  -14.407 1    57.25  ? 401 ALA B O   1 
ATOM   4287 C  CB  . ALA B 2 231 ? -24.344 9.525   -14.912 1    49.94  ? 401 ALA B CB  1 
ATOM   4288 N  N   . PRO B 2 232 ? -23.858 12.342  -16.513 1    54.78  ? 402 PRO B N   1 
ATOM   4289 C  CA  . PRO B 2 232 ? -22.993 13.423  -16.984 1    56.43  ? 402 PRO B CA  1 
ATOM   4290 C  C   . PRO B 2 232 ? -23.21  14.767  -16.29  1    60.28  ? 402 PRO B C   1 
ATOM   4291 O  O   . PRO B 2 232 ? -22.285 15.576  -16.225 1    62.34  ? 402 PRO B O   1 
ATOM   4292 C  CB  . PRO B 2 232 ? -23.308 13.504  -18.497 1    56.51  ? 402 PRO B CB  1 
ATOM   4293 C  CG  . PRO B 2 232 ? -23.808 12.115  -18.847 1    55.75  ? 402 PRO B CG  1 
ATOM   4294 C  CD  . PRO B 2 232 ? -24.568 11.661  -17.613 1    53.96  ? 402 PRO B CD  1 
ATOM   4295 N  N   . GLN B 2 233 ? -24.435 15.008  -15.798 1    59.38  ? 403 GLN B N   1 
ATOM   4296 C  CA  . GLN B 2 233 ? -24.802 16.295  -15.224 1    61.46  ? 403 GLN B CA  1 
ATOM   4297 C  C   . GLN B 2 233 ? -24.632 16.306  -13.704 1    60.95  ? 403 GLN B C   1 
ATOM   4298 O  O   . GLN B 2 233 ? -24.525 17.384  -13.138 1    66.7   ? 403 GLN B O   1 
ATOM   4299 C  CB  . GLN B 2 233 ? -26.239 16.693  -15.55  1    65.4   ? 403 GLN B CB  1 
ATOM   4300 C  CG  . GLN B 2 233 ? -26.394 17.352  -16.913 1    80.99  ? 403 GLN B CG  1 
ATOM   4301 C  CD  . GLN B 2 233 ? -26.148 16.392  -18.055 1    93.47  ? 403 GLN B CD  1 
ATOM   4302 O  OE1 . GLN B 2 233 ? -25.265 16.605  -18.892 1    99.9   ? 403 GLN B OE1 1 
ATOM   4303 N  NE2 . GLN B 2 233 ? -26.92  15.309  -18.082 1    98.23  ? 403 GLN B NE2 1 
ATOM   4304 N  N   . HIS B 2 234 ? -24.596 15.126  -13.059 1    54.12  ? 404 HIS B N   1 
ATOM   4305 C  CA  . HIS B 2 234 ? -24.505 15.041  -11.609 1    52     ? 404 HIS B CA  1 
ATOM   4306 C  C   . HIS B 2 234 ? -23.318 15.855  -11.101 1    52.6   ? 404 HIS B C   1 
ATOM   4307 O  O   . HIS B 2 234 ? -22.257 15.868  -11.721 1    52.54  ? 404 HIS B O   1 
ATOM   4308 C  CB  . HIS B 2 234 ? -24.405 13.584  -11.175 1    47.42  ? 404 HIS B CB  1 
ATOM   4309 C  CG  . HIS B 2 234 ? -24.731 13.285  -9.753  1    50.27  ? 404 HIS B CG  1 
ATOM   4310 N  ND1 . HIS B 2 234 ? -23.911 13.575  -8.675  1    51.74  ? 404 HIS B ND1 1 
ATOM   4311 C  CD2 . HIS B 2 234 ? -25.787 12.615  -9.244  1    50.38  ? 404 HIS B CD2 1 
ATOM   4312 C  CE1 . HIS B 2 234 ? -24.468 13.121  -7.557  1    48.91  ? 404 HIS B CE1 1 
ATOM   4313 N  NE2 . HIS B 2 234 ? -25.596 12.525  -7.874  1    50.98  ? 404 HIS B NE2 1 
ATOM   4314 N  N   . ALA B 2 235 ? -23.528 16.536  -9.975  1    51.16  ? 405 ALA B N   1 
ATOM   4315 C  CA  . ALA B 2 235 ? -22.49  17.285  -9.274  1    53.21  ? 405 ALA B CA  1 
ATOM   4316 C  C   . ALA B 2 235 ? -21.251 16.421  -8.975  1    53.07  ? 405 ALA B C   1 
ATOM   4317 O  O   . ALA B 2 235 ? -20.139 16.921  -8.959  1    56.83  ? 405 ALA B O   1 
ATOM   4318 C  CB  . ALA B 2 235 ? -23.086 17.851  -7.991  1    49.77  ? 405 ALA B CB  1 
ATOM   4319 N  N   . GLN B 2 236 ? -21.432 15.127  -8.723  1    50.13  ? 406 GLN B N   1 
ATOM   4320 C  CA  . GLN B 2 236 ? -20.318 14.238  -8.424  1    52.03  ? 406 GLN B CA  1 
ATOM   4321 C  C   . GLN B 2 236 ? -19.954 13.413  -9.659  1    51.82  ? 406 GLN B C   1 
ATOM   4322 O  O   . GLN B 2 236 ? -20.837 12.839  -10.297 1    54.65  ? 406 GLN B O   1 
ATOM   4323 C  CB  . GLN B 2 236 ? -20.729 13.309  -7.272  1    53.81  ? 406 GLN B CB  1 
ATOM   4324 C  CG  . GLN B 2 236 ? -20.586 13.884  -5.853  1    52.76  ? 406 GLN B CG  1 
ATOM   4325 C  CD  . GLN B 2 236 ? -21.398 15.134  -5.583  1    55.32  ? 406 GLN B CD  1 
ATOM   4326 O  OE1 . GLN B 2 236 ? -22.623 15.167  -5.763  1    57.64  ? 406 GLN B OE1 1 
ATOM   4327 N  NE2 . GLN B 2 236 ? -20.716 16.175  -5.133  1    51.48  ? 406 GLN B NE2 1 
ATOM   4328 N  N   . GLN B 2 237 ? -18.651 13.334  -9.975  1    50.19  ? 407 GLN B N   1 
ATOM   4329 C  CA  . GLN B 2 237 ? -18.175 12.869  -11.271 1    48.36  ? 407 GLN B CA  1 
ATOM   4330 C  C   . GLN B 2 237 ? -17.013 11.875  -11.142 1    48.74  ? 407 GLN B C   1 
ATOM   4331 O  O   . GLN B 2 237 ? -16.508 11.39   -12.157 1    50.67  ? 407 GLN B O   1 
ATOM   4332 C  CB  . GLN B 2 237 ? -17.73  14.07   -12.104 1    46.72  ? 407 GLN B CB  1 
ATOM   4333 C  CG  . GLN B 2 237 ? -18.862 14.894  -12.691 1    48.3   ? 407 GLN B CG  1 
ATOM   4334 C  CD  . GLN B 2 237 ? -19.674 14.101  -13.689 1    53.57  ? 407 GLN B CD  1 
ATOM   4335 O  OE1 . GLN B 2 237 ? -19.114 13.388  -14.518 1    59.32  ? 407 GLN B OE1 1 
ATOM   4336 N  NE2 . GLN B 2 237 ? -20.996 14.161  -13.62  1    52.93  ? 407 GLN B NE2 1 
ATOM   4337 N  N   . SER B 2 238 ? -16.614 11.534  -9.915  1    44.65  ? 408 SER B N   1 
ATOM   4338 C  CA  . SER B 2 238 ? -15.436 10.702  -9.731  1    46.62  ? 408 SER B CA  1 
ATOM   4339 C  C   . SER B 2 238 ? -15.624 9.283   -10.288 1    44.92  ? 408 SER B C   1 
ATOM   4340 O  O   . SER B 2 238 ? -14.673 8.662   -10.782 1    43.54  ? 408 SER B O   1 
ATOM   4341 C  CB  . SER B 2 238 ? -15.042 10.67   -8.272  1    45.22  ? 408 SER B CB  1 
ATOM   4342 O  OG  . SER B 2 238 ? -14.708 11.986  -7.85   1    49.48  ? 408 SER B OG  1 
ATOM   4343 N  N   . ILE B 2 239 ? -16.841 8.762   -10.187 1    41.76  ? 409 ILE B N   1 
ATOM   4344 C  CA  . ILE B 2 239 ? -17.125 7.414   -10.664 1    42.38  ? 409 ILE B CA  1 
ATOM   4345 C  C   . ILE B 2 239 ? -17.074 7.377   -12.197 1    47.54  ? 409 ILE B C   1 
ATOM   4346 O  O   . ILE B 2 239 ? -16.49  6.454   -12.768 1    47.88  ? 409 ILE B O   1 
ATOM   4347 C  CB  . ILE B 2 239 ? -18.448 6.872   -10.082 1    39.43  ? 409 ILE B CB  1 
ATOM   4348 C  CG1 . ILE B 2 239 ? -18.357 6.673   -8.557  1    35.97  ? 409 ILE B CG1 1 
ATOM   4349 C  CG2 . ILE B 2 239 ? -18.847 5.576   -10.768 1    37.39  ? 409 ILE B CG2 1 
ATOM   4350 C  CD1 . ILE B 2 239 ? -19.695 6.487   -7.882  1    33.43  ? 409 ILE B CD1 1 
ATOM   4351 N  N   . ARG B 2 240 ? -17.621 8.409   -12.861 1    45.08  ? 410 ARG B N   1 
ATOM   4352 C  CA  . ARG B 2 240 ? -17.529 8.449   -14.301 1    49.56  ? 410 ARG B CA  1 
ATOM   4353 C  C   . ARG B 2 240 ? -16.072 8.537   -14.754 1    52.12  ? 410 ARG B C   1 
ATOM   4354 O  O   . ARG B 2 240 ? -15.709 7.877   -15.737 1    52.97  ? 410 ARG B O   1 
ATOM   4355 C  CB  . ARG B 2 240 ? -18.332 9.614   -14.884 1    53.39  ? 410 ARG B CB  1 
ATOM   4356 C  CG  . ARG B 2 240 ? -19.839 9.43    -14.838 1    51.98  ? 410 ARG B CG  1 
ATOM   4357 C  CD  . ARG B 2 240 ? -20.521 10.514  -15.654 1    51.06  ? 410 ARG B CD  1 
ATOM   4358 N  NE  . ARG B 2 240 ? -20.201 10.356  -17.074 1    52.71  ? 410 ARG B NE  1 
ATOM   4359 C  CZ  . ARG B 2 240 ? -19.825 11.349  -17.863 1    51.01  ? 410 ARG B CZ  1 
ATOM   4360 N  NH1 . ARG B 2 240 ? -19.749 11.167  -19.168 1    48.44  ? 410 ARG B NH1 1 
ATOM   4361 N  NH2 . ARG B 2 240 ? -19.575 12.523  -17.338 1    50.24  ? 410 ARG B NH2 1 
ATOM   4362 N  N   . GLU B 2 241 ? -15.27  9.374   -14.067 1    50.77  ? 411 GLU B N   1 
ATOM   4363 C  CA  . GLU B 2 241 ? -13.863 9.592   -14.414 1    54.38  ? 411 GLU B CA  1 
ATOM   4364 C  C   . GLU B 2 241 ? -13.102 8.269   -14.29  1    51.16  ? 411 GLU B C   1 
ATOM   4365 O  O   . GLU B 2 241 ? -12.32  7.903   -15.165 1    51.22  ? 411 GLU B O   1 
ATOM   4366 C  CB  . GLU B 2 241 ? -13.153 10.634  -13.534 1    56.37  ? 411 GLU B CB  1 
ATOM   4367 C  CG  . GLU B 2 241 ? -13.715 12.058  -13.547 1    63.75  ? 411 GLU B CG  1 
ATOM   4368 C  CD  . GLU B 2 241 ? -13.989 12.658  -14.928 1    75.62  ? 411 GLU B CD  1 
ATOM   4369 O  OE1 . GLU B 2 241 ? -13.112 12.49   -15.82  1    81.09  ? 411 GLU B OE1 1 
ATOM   4370 O  OE2 . GLU B 2 241 ? -15.042 13.331  -15.119 1    76.25  ? 411 GLU B OE2 1 
ATOM   4371 N  N   . LYS B 2 242 ? -13.389 7.548   -13.202 1    47.55  ? 412 LYS B N   1 
ATOM   4372 C  CA  . LYS B 2 242 ? -12.808 6.256   -12.896 1    48.57  ? 412 LYS B CA  1 
ATOM   4373 C  C   . LYS B 2 242 ? -13.154 5.24    -13.985 1    51.34  ? 412 LYS B C   1 
ATOM   4374 O  O   . LYS B 2 242 ? -12.281 4.52    -14.468 1    50.85  ? 412 LYS B O   1 
ATOM   4375 C  CB  . LYS B 2 242 ? -13.332 5.85    -11.519 1    41.78  ? 412 LYS B CB  1 
ATOM   4376 C  CG  . LYS B 2 242 ? -13.015 4.46    -11.096 1    42.23  ? 412 LYS B CG  1 
ATOM   4377 C  CD  . LYS B 2 242 ? -13.515 4.188   -9.675  1    42.41  ? 412 LYS B CD  1 
ATOM   4378 C  CE  . LYS B 2 242 ? -13.394 2.735   -9.284  1    34.47  ? 412 LYS B CE  1 
ATOM   4379 N  NZ  . LYS B 2 242 ? -14.095 2.461   -8.043  1    32.2   ? 412 LYS B NZ  1 
ATOM   4380 N  N   . TYR B 2 243 ? -14.422 5.226   -14.404 1    48.11  ? 413 TYR B N   1 
ATOM   4381 C  CA  . TYR B 2 243 ? -14.854 4.228   -15.361 1    48.82  ? 413 TYR B CA  1 
ATOM   4382 C  C   . TYR B 2 243 ? -14.527 4.609   -16.813 1    51.01  ? 413 TYR B C   1 
ATOM   4383 O  O   . TYR B 2 243 ? -14.954 3.89    -17.723 1    48.31  ? 413 TYR B O   1 
ATOM   4384 C  CB  . TYR B 2 243 ? -16.286 3.81    -15.077 1    44.05  ? 413 TYR B CB  1 
ATOM   4385 C  CG  . TYR B 2 243 ? -16.362 2.801   -13.943 1    45.93  ? 413 TYR B CG  1 
ATOM   4386 C  CD1 . TYR B 2 243 ? -16.273 3.21    -12.611 1    45.85  ? 413 TYR B CD1 1 
ATOM   4387 C  CD2 . TYR B 2 243 ? -16.548 1.44    -14.196 1    41.77  ? 413 TYR B CD2 1 
ATOM   4388 C  CE1 . TYR B 2 243 ? -16.371 2.302   -11.567 1    43.59  ? 413 TYR B CE1 1 
ATOM   4389 C  CE2 . TYR B 2 243 ? -16.647 0.528   -13.162 1    39.78  ? 413 TYR B CE2 1 
ATOM   4390 C  CZ  . TYR B 2 243 ? -16.55  0.953   -11.835 1    43.61  ? 413 TYR B CZ  1 
ATOM   4391 O  OH  . TYR B 2 243 ? -16.622 0.055   -10.781 1    39.04  ? 413 TYR B OH  1 
ATOM   4392 N  N   . LYS B 2 244 ? -13.706 5.65    -17.023 1    50.72  ? 414 LYS B N   1 
ATOM   4393 C  CA  . LYS B 2 244 ? -13.088 5.893   -18.327 1    58.31  ? 414 LYS B CA  1 
ATOM   4394 C  C   . LYS B 2 244 ? -11.878 4.97    -18.524 1    60.89  ? 414 LYS B C   1 
ATOM   4395 O  O   . LYS B 2 244 ? -11.532 4.6     -19.651 1    64.1   ? 414 LYS B O   1 
ATOM   4396 C  CB  . LYS B 2 244 ? -12.636 7.35    -18.507 1    57.08  ? 414 LYS B CB  1 
ATOM   4397 C  CG  . LYS B 2 244 ? -13.757 8.316   -18.746 1    60.55  ? 414 LYS B CG  1 
ATOM   4398 C  CD  . LYS B 2 244 ? -13.456 9.797   -18.535 1    68     ? 414 LYS B CD  1 
ATOM   4399 C  CE  . LYS B 2 244 ? -14.759 10.574  -18.739 1    76.95  ? 414 LYS B CE  1 
ATOM   4400 N  NZ  . LYS B 2 244 ? -15.124 11.53   -17.687 1    73.74  ? 414 LYS B NZ  1 
ATOM   4401 N  N   . ASN B 2 245 ? -11.228 4.626   -17.404 1    61.52  ? 415 ASN B N   1 
ATOM   4402 C  CA  . ASN B 2 245 ? -10.008 3.837   -17.413 1    62.94  ? 415 ASN B CA  1 
ATOM   4403 C  C   . ASN B 2 245 ? -10.249 2.511   -18.133 1    62.45  ? 415 ASN B C   1 
ATOM   4404 O  O   . ASN B 2 245 ? -11.302 1.882   -18.001 1    57.58  ? 415 ASN B O   1 
ATOM   4405 C  CB  . ASN B 2 245 ? -9.498  3.58    -15.998 1    66.21  ? 415 ASN B CB  1 
ATOM   4406 C  CG  . ASN B 2 245 ? -8.05   3.147   -15.954 1    76.01  ? 415 ASN B CG  1 
ATOM   4407 O  OD1 . ASN B 2 245 ? -7.759  1.958   -15.78  1    80.04  ? 415 ASN B OD1 1 
ATOM   4408 N  ND2 . ASN B 2 245 ? -7.128  4.085   -16.131 1    81.55  ? 415 ASN B ND2 1 
ATOM   4409 N  N   . SER B 2 246 ? -9.219  2.073   -18.858 1    62.6   ? 416 SER B N   1 
ATOM   4410 C  CA  . SER B 2 246 ? -9.297  0.835   -19.606 1    64.5   ? 416 SER B CA  1 
ATOM   4411 C  C   . SER B 2 246 ? -9.376  -0.366  -18.654 1    61.46  ? 416 SER B C   1 
ATOM   4412 O  O   . SER B 2 246 ? -9.942  -1.407  -18.99  1    56.61  ? 416 SER B O   1 
ATOM   4413 C  CB  . SER B 2 246 ? -8.17   0.75    -20.593 1    71.2   ? 416 SER B CB  1 
ATOM   4414 O  OG  . SER B 2 246 ? -6.93   0.691   -19.915 1    75.35  ? 416 SER B OG  1 
ATOM   4415 N  N   . LYS B 2 247 ? -8.838  -0.222  -17.443 1    58.18  ? 417 LYS B N   1 
ATOM   4416 C  CA  . LYS B 2 247 ? -9.09   -1.208  -16.403 1    56.63  ? 417 LYS B CA  1 
ATOM   4417 C  C   . LYS B 2 247 ? -10.564 -1.619  -16.447 1    56.64  ? 417 LYS B C   1 
ATOM   4418 O  O   . LYS B 2 247 ? -10.888 -2.783  -16.275 1    59.66  ? 417 LYS B O   1 
ATOM   4419 C  CB  . LYS B 2 247 ? -8.706  -0.582  -15.055 1    55.8   ? 417 LYS B CB  1 
ATOM   4420 C  CG  . LYS B 2 247 ? -8.775  -1.462  -13.81  1    55.08  ? 417 LYS B CG  1 
ATOM   4421 C  CD  . LYS B 2 247 ? -8.375  -0.627  -12.595 1    64.05  ? 417 LYS B CD  1 
ATOM   4422 C  CE  . LYS B 2 247 ? -7.934  -1.355  -11.367 1    70.91  ? 417 LYS B CE  1 
ATOM   4423 N  NZ  . LYS B 2 247 ? -8.835  -2.507  -11.247 1    75.84  ? 417 LYS B NZ  1 
ATOM   4424 N  N   . TYR B 2 248 ? -11.457 -0.657  -16.715 1    54.36  ? 418 TYR B N   1 
ATOM   4425 C  CA  . TYR B 2 248 ? -12.897 -0.859  -16.647 1    51.11  ? 418 TYR B CA  1 
ATOM   4426 C  C   . TYR B 2 248 ? -13.517 -0.771  -18.047 1    54.82  ? 418 TYR B C   1 
ATOM   4427 O  O   . TYR B 2 248 ? -14.717 -0.551  -18.192 1    51.89  ? 418 TYR B O   1 
ATOM   4428 C  CB  . TYR B 2 248 ? -13.513 0.174   -15.691 1    52.52  ? 418 TYR B CB  1 
ATOM   4429 C  CG  . TYR B 2 248 ? -12.952 0.155   -14.272 1    50.86  ? 418 TYR B CG  1 
ATOM   4430 C  CD1 . TYR B 2 248 ? -13.235 -0.906  -13.41  1    47.98  ? 418 TYR B CD1 1 
ATOM   4431 C  CD2 . TYR B 2 248 ? -12.143 1.181   -13.802 1    47     ? 418 TYR B CD2 1 
ATOM   4432 C  CE1 . TYR B 2 248 ? -12.748 -0.936  -12.113 1    49.48  ? 418 TYR B CE1 1 
ATOM   4433 C  CE2 . TYR B 2 248 ? -11.625 1.14    -12.515 1    52.9   ? 418 TYR B CE2 1 
ATOM   4434 C  CZ  . TYR B 2 248 ? -11.92  0.079   -11.665 1    56.92  ? 418 TYR B CZ  1 
ATOM   4435 O  OH  . TYR B 2 248 ? -11.4   0.026   -10.387 1    65.45  ? 418 TYR B OH  1 
ATOM   4436 N  N   . HIS B 2 249 ? -12.695 -0.97   -19.08  1    52.8   ? 419 HIS B N   1 
ATOM   4437 C  CA  . HIS B 2 249 ? -13.15  -1.05   -20.457 1    52.1   ? 419 HIS B CA  1 
ATOM   4438 C  C   . HIS B 2 249 ? -13.828 0.248   -20.894 1    54.18  ? 419 HIS B C   1 
ATOM   4439 O  O   . HIS B 2 249 ? -14.592 0.254   -21.855 1    52.09  ? 419 HIS B O   1 
ATOM   4440 C  CB  . HIS B 2 249 ? -13.998 -2.3    -20.68  1    52.48  ? 419 HIS B CB  1 
ATOM   4441 C  CG  . HIS B 2 249 ? -13.305 -3.552  -20.231 1    61.81  ? 419 HIS B CG  1 
ATOM   4442 N  ND1 . HIS B 2 249 ? -13.52  -4.077  -18.961 1    62.84  ? 419 HIS B ND1 1 
ATOM   4443 C  CD2 . HIS B 2 249 ? -12.421 -4.371  -20.842 1    58.3   ? 419 HIS B CD2 1 
ATOM   4444 C  CE1 . HIS B 2 249 ? -12.799 -5.188  -18.823 1    62.58  ? 419 HIS B CE1 1 
ATOM   4445 N  NE2 . HIS B 2 249 ? -12.113 -5.373  -19.946 1    61.29  ? 419 HIS B NE2 1 
ATOM   4446 N  N   . GLY B 2 250 ? -13.514 1.356   -20.205 1    53.13  ? 420 GLY B N   1 
ATOM   4447 C  CA  . GLY B 2 250 ? -14.02  2.662   -20.589 1    51.68  ? 420 GLY B CA  1 
ATOM   4448 C  C   . GLY B 2 250 ? -15.547 2.713   -20.646 1    50.16  ? 420 GLY B C   1 
ATOM   4449 O  O   . GLY B 2 250 ? -16.089 3.491   -21.426 1    50.03  ? 420 GLY B O   1 
ATOM   4450 N  N   . VAL B 2 251 ? -16.23  1.954   -19.767 1    47.48  ? 421 VAL B N   1 
ATOM   4451 C  CA  . VAL B 2 251 ? -17.671 1.791   -19.877 1    46.95  ? 421 VAL B CA  1 
ATOM   4452 C  C   . VAL B 2 251 ? -18.442 3.086   -19.632 1    48.41  ? 421 VAL B C   1 
ATOM   4453 O  O   . VAL B 2 251 ? -19.535 3.223   -20.147 1    51.57  ? 421 VAL B O   1 
ATOM   4454 C  CB  . VAL B 2 251 ? -18.23  0.671   -19.007 1    45.93  ? 421 VAL B CB  1 
ATOM   4455 C  CG1 . VAL B 2 251 ? -17.767 -0.689  -19.541 1    45.18  ? 421 VAL B CG1 1 
ATOM   4456 C  CG2 . VAL B 2 251 ? -17.918 0.9     -17.525 1    41.69  ? 421 VAL B CG2 1 
ATOM   4457 N  N   . SER B 2 252 ? -17.887 4.042   -18.889 1    49.31  ? 422 SER B N   1 
ATOM   4458 C  CA  . SER B 2 252 ? -18.597 5.297   -18.665 1    50.93  ? 422 SER B CA  1 
ATOM   4459 C  C   . SER B 2 252 ? -18.753 6.099   -19.961 1    53.75  ? 422 SER B C   1 
ATOM   4460 O  O   . SER B 2 252 ? -19.395 7.143   -19.961 1    56.35  ? 422 SER B O   1 
ATOM   4461 C  CB  . SER B 2 252 ? -18.009 6.126   -17.526 1    50.35  ? 422 SER B CB  1 
ATOM   4462 O  OG  . SER B 2 252 ? -16.697 6.593   -17.808 1    57.41  ? 422 SER B OG  1 
ATOM   4463 N  N   . LEU B 2 253 ? -18.166 5.628   -21.072 1    54.67  ? 423 LEU B N   1 
ATOM   4464 C  CA  . LEU B 2 253 ? -18.271 6.338   -22.345 1    57.01  ? 423 LEU B CA  1 
ATOM   4465 C  C   . LEU B 2 253 ? -19.429 5.793   -23.181 1    57.47  ? 423 LEU B C   1 
ATOM   4466 O  O   . LEU B 2 253 ? -19.825 6.404   -24.172 1    64.2   ? 423 LEU B O   1 
ATOM   4467 C  CB  . LEU B 2 253 ? -16.973 6.285   -23.154 1    59.46  ? 423 LEU B CB  1 
ATOM   4468 C  CG  . LEU B 2 253 ? -15.702 6.777   -22.447 1    61.07  ? 423 LEU B CG  1 
ATOM   4469 C  CD1 . LEU B 2 253 ? -14.56  6.664   -23.454 1    64.61  ? 423 LEU B CD1 1 
ATOM   4470 C  CD2 . LEU B 2 253 ? -15.827 8.195   -21.927 1    62.28  ? 423 LEU B CD2 1 
ATOM   4471 N  N   . LEU B 2 254 ? -19.945 4.621   -22.8   1    56.05  ? 424 LEU B N   1 
ATOM   4472 C  CA  . LEU B 2 254 ? -21.098 4.017   -23.459 1    54.48  ? 424 LEU B CA  1 
ATOM   4473 C  C   . LEU B 2 254 ? -22.305 4.936   -23.274 1    56.62  ? 424 LEU B C   1 
ATOM   4474 O  O   . LEU B 2 254 ? -22.443 5.584   -22.245 1    58.87  ? 424 LEU B O   1 
ATOM   4475 C  CB  . LEU B 2 254 ? -21.327 2.624   -22.86  1    46.55  ? 424 LEU B CB  1 
ATOM   4476 C  CG  . LEU B 2 254 ? -20.237 1.578   -23.141 1    44.3   ? 424 LEU B CG  1 
ATOM   4477 C  CD1 . LEU B 2 254 ? -20.583 0.257   -22.494 1    39.37  ? 424 LEU B CD1 1 
ATOM   4478 C  CD2 . LEU B 2 254 ? -20     1.401   -24.683 1    43.62  ? 424 LEU B CD2 1 
ATOM   4479 N  N   . ASN B 2 255 ? -23.192 4.994   -24.272 1    59.19  ? 425 ASN B N   1 
ATOM   4480 C  CA  . ASN B 2 255 ? -24.383 5.817   -24.158 1    59.37  ? 425 ASN B CA  1 
ATOM   4481 C  C   . ASN B 2 255 ? -25.487 5.027   -23.47  1    58.58  ? 425 ASN B C   1 
ATOM   4482 O  O   . ASN B 2 255 ? -25.783 3.901   -23.873 1    58.54  ? 425 ASN B O   1 
ATOM   4483 C  CB  . ASN B 2 255 ? -24.861 6.291   -25.521 1    61.99  ? 425 ASN B CB  1 
ATOM   4484 C  CG  . ASN B 2 255 ? -23.824 7.172   -26.166 1    66.9   ? 425 ASN B CG  1 
ATOM   4485 O  OD1 . ASN B 2 255 ? -23.419 6.905   -27.305 1    71.12  ? 425 ASN B OD1 1 
ATOM   4486 N  ND2 . ASN B 2 255 ? -23.396 8.215   -25.457 1    66.61  ? 425 ASN B ND2 1 
ATOM   4487 N  N   . PRO B 2 256 ? -26.166 5.617   -22.457 1    58.47  ? 426 PRO B N   1 
ATOM   4488 C  CA  . PRO B 2 256 ? -27.36  4.989   -21.884 1    58.03  ? 426 PRO B CA  1 
ATOM   4489 C  C   . PRO B 2 256 ? -28.381 4.778   -23.012 1    60.29  ? 426 PRO B C   1 
ATOM   4490 O  O   . PRO B 2 256 ? -28.4   5.549   -23.976 1    59.62  ? 426 PRO B O   1 
ATOM   4491 C  CB  . PRO B 2 256 ? -27.857 5.986   -20.821 1    53.57  ? 426 PRO B CB  1 
ATOM   4492 C  CG  . PRO B 2 256 ? -27.175 7.289   -21.165 1    55.11  ? 426 PRO B CG  1 
ATOM   4493 C  CD  . PRO B 2 256 ? -25.871 6.94    -21.872 1    57.73  ? 426 PRO B CD  1 
ATOM   4494 N  N   . PRO B 2 257 ? -29.248 3.734   -22.932 1    57.24  ? 427 PRO B N   1 
ATOM   4495 C  CA  . PRO B 2 257 ? -30.355 3.59    -23.885 1    54.87  ? 427 PRO B CA  1 
ATOM   4496 C  C   . PRO B 2 257 ? -31.427 4.606   -23.478 1    56.1   ? 427 PRO B C   1 
ATOM   4497 O  O   . PRO B 2 257 ? -31.563 4.922   -22.295 1    56.13  ? 427 PRO B O   1 
ATOM   4498 C  CB  . PRO B 2 257 ? -30.802 2.131   -23.645 1    54.13  ? 427 PRO B CB  1 
ATOM   4499 C  CG  . PRO B 2 257 ? -30.501 1.883   -22.153 1    50.89  ? 427 PRO B CG  1 
ATOM   4500 C  CD  . PRO B 2 257 ? -29.247 2.704   -21.861 1    51.23  ? 427 PRO B CD  1 
ATOM   4501 N  N   . GLU B 2 258 ? -32.158 5.134   -24.451 1    60.75  ? 428 GLU B N   1 
ATOM   4502 C  CA  . GLU B 2 258 ? -33.157 6.161   -24.194 1    68.78  ? 428 GLU B CA  1 
ATOM   4503 C  C   . GLU B 2 258 ? -34.371 5.6     -23.451 1    69.9   ? 428 GLU B C   1 
ATOM   4504 O  O   . GLU B 2 258 ? -34.961 6.337   -22.665 1    72.65  ? 428 GLU B O   1 
ATOM   4505 C  CB  . GLU B 2 258 ? -33.658 6.788   -25.492 1    75.54  ? 428 GLU B CB  1 
ATOM   4506 C  CG  . GLU B 2 258 ? -32.561 7.484   -26.297 1    86.03  ? 428 GLU B CG  1 
ATOM   4507 C  CD  . GLU B 2 258 ? -32.988 7.97    -27.678 1    99.04  ? 428 GLU B CD  1 
ATOM   4508 O  OE1 . GLU B 2 258 ? -34.126 7.681   -28.155 1    103.53 ? 428 GLU B OE1 1 
ATOM   4509 O  OE2 . GLU B 2 258 ? -32.14  8.672   -28.281 1    103.41 ? 428 GLU B OE2 1 
ATOM   4510 N  N   . THR B 2 259 ? -34.744 4.331   -23.721 1    66.08  ? 429 THR B N   1 
ATOM   4511 C  CA  . THR B 2 259 ? -35.921 3.68    -23.15  1    66.28  ? 429 THR B CA  1 
ATOM   4512 C  C   . THR B 2 259 ? -35.599 2.221   -22.829 1    67.59  ? 429 THR B C   1 
ATOM   4513 O  O   . THR B 2 259 ? -34.658 1.664   -23.41  1    68.86  ? 429 THR B O   1 
ATOM   4514 C  CB  . THR B 2 259 ? -37.126 3.742   -24.1   1    68.2   ? 429 THR B CB  1 
ATOM   4515 O  OG1 . THR B 2 259 ? -36.894 2.829   -25.169 1    64.97  ? 429 THR B OG1 1 
ATOM   4516 C  CG2 . THR B 2 259 ? -37.455 5.137   -24.608 1    68.27  ? 429 THR B CG2 1 
ATOM   4517 N  N   . LEU B 2 260 ? -36.412 1.601   -21.947 1    64.51  ? 430 LEU B N   1 
ATOM   4518 C  CA  . LEU B 2 260 ? -36.139 0.271   -21.409 1    65.43  ? 430 LEU B CA  1 
ATOM   4519 C  C   . LEU B 2 260 ? -37.092 -0.808  -21.934 1    74.05  ? 430 LEU B C   1 
ATOM   4520 O  O   . LEU B 2 260 ? -36.733 -1.995  -21.877 1    67.19  ? 430 LEU B O   1 
ATOM   4521 C  CB  . LEU B 2 260 ? -36.216 0.284   -19.885 1    61.83  ? 430 LEU B CB  1 
ATOM   4522 C  CG  . LEU B 2 260 ? -35.17  1.083   -19.11  1    62.99  ? 430 LEU B CG  1 
ATOM   4523 C  CD1 . LEU B 2 260 ? -35.287 0.692   -17.641 1    63.09  ? 430 LEU B CD1 1 
ATOM   4524 C  CD2 . LEU B 2 260 ? -33.772 0.861   -19.639 1    61.16  ? 430 LEU B CD2 1 
ATOM   4525 N  N   . ASN B 2 261 ? -38.327 -0.408  -22.329 1    81.52  ? 431 ASN B N   1 
ATOM   4526 C  CA  . ASN B 2 261 ? -39.393 -1.309  -22.77  1    85.79  ? 431 ASN B CA  1 
ATOM   4527 C  C   . ASN B 2 261 ? -39.736 -2.343  -21.694 1    87.55  ? 431 ASN B C   1 
ATOM   4528 O  O   . ASN B 2 261 ? -39.757 -3.544  -21.984 1    80.32  ? 431 ASN B O   1 
ATOM   4529 C  CB  . ASN B 2 261 ? -38.994 -2.086  -24.023 1    86.46  ? 431 ASN B CB  1 
ATOM   4530 C  CG  . ASN B 2 261 ? -38.595 -1.178  -25.162 1    92.69  ? 431 ASN B CG  1 
ATOM   4531 O  OD1 . ASN B 2 261 ? -37.479 -1.309  -25.675 1    97.19  ? 431 ASN B OD1 1 
ATOM   4532 N  ND2 . ASN B 2 261 ? -39.473 -0.268  -25.574 1    86.46  ? 431 ASN B ND2 1 
ATOM   4533 N  N   . VAL B 2 262 ? -40.007 -1.867  -20.466 1    92.04  ? 432 VAL B N   1 
ATOM   4534 C  CA  . VAL B 2 262 ? -40.079 -2.718  -19.283 1    89.33  ? 432 VAL B CA  1 
ATOM   4535 C  C   . VAL B 2 262 ? -41.449 -2.501  -18.615 1    94.08  ? 432 VAL B C   1 
ATOM   4536 O  O   . VAL B 2 262 ? -42.454 -2.606  -19.365 1    93.26  ? 432 VAL B O   1 
ATOM   4537 C  CB  . VAL B 2 262 ? -38.913 -2.424  -18.312 1    93.91  ? 432 VAL B CB  1 
ATOM   4538 C  CG1 . VAL B 2 262 ? -39.015 -3.204  -17.008 1    92.69  ? 432 VAL B CG1 1 
ATOM   4539 C  CG2 . VAL B 2 262 ? -37.549 -2.674  -18.937 1    90.4   ? 432 VAL B CG2 1 
ATOM   4540 N  N   . SER C 1 4   ? -15.581 4.426   30.35   1    84.04  ? 0   SER C N   1 
ATOM   4541 C  CA  . SER C 1 4   ? -16.051 4.353   28.943  1    90.66  ? 0   SER C CA  1 
ATOM   4542 C  C   . SER C 1 4   ? -16.596 5.714   28.471  1    93.47  ? 0   SER C C   1 
ATOM   4543 O  O   . SER C 1 4   ? -17.505 5.765   27.638  1    90.58  ? 0   SER C O   1 
ATOM   4544 C  CB  . SER C 1 4   ? -17.103 3.253   28.813  1    81.53  ? 0   SER C CB  1 
ATOM   4545 O  OG  . SER C 1 4   ? -16.746 2.063   29.502  1    77.35  ? 0   SER C OG  1 
ATOM   4546 N  N   . MET C 1 5   ? -16.032 6.831   28.966  1    77.31  ? 1   MET C N   1 
ATOM   4547 C  CA  . MET C 1 5   ? -16.693 8.115   28.767  1    67.34  ? 1   MET C CA  1 
ATOM   4548 C  C   . MET C 1 5   ? -15.747 9.204   28.248  1    66.97  ? 1   MET C C   1 
ATOM   4549 O  O   . MET C 1 5   ? -16.097 10.381  28.295  1    60.84  ? 1   MET C O   1 
ATOM   4550 C  CB  . MET C 1 5   ? -17.39  8.594   30.052  1    67.19  ? 1   MET C CB  1 
ATOM   4551 C  CG  . MET C 1 5   ? -18.401 7.616   30.612  1    65.82  ? 1   MET C CG  1 
ATOM   4552 S  SD  . MET C 1 5   ? -19.844 7.416   29.544  1    72.27  ? 1   MET C SD  1 
ATOM   4553 C  CE  . MET C 1 5   ? -20.65  9.008   29.792  1    63.53  ? 1   MET C CE  1 
ATOM   4554 N  N   A GLU C 1 6   ? -14.577 8.818   27.722  0.5  69.88  ? 2   GLU C N   1 
ATOM   4555 N  N   B GLU C 1 6   ? -14.581 8.78    27.731  0.5  68.57  ? 2   GLU C N   1 
ATOM   4556 C  CA  A GLU C 1 6   ? -13.571 9.796   27.33   0.5  70.32  ? 2   GLU C CA  1 
ATOM   4557 C  CA  B GLU C 1 6   ? -13.511 9.64    27.24   0.5  68.25  ? 2   GLU C CA  1 
ATOM   4558 C  C   A GLU C 1 6   ? -13.976 10.512  26.038  0.5  67.76  ? 2   GLU C C   1 
ATOM   4559 C  C   B GLU C 1 6   ? -13.986 10.49   26.059  0.5  66.52  ? 2   GLU C C   1 
ATOM   4560 O  O   A GLU C 1 6   ? -13.438 11.573  25.753  0.5  70.31  ? 2   GLU C O   1 
ATOM   4561 O  O   B GLU C 1 6   ? -13.497 11.6    25.862  0.5  68.88  ? 2   GLU C O   1 
ATOM   4562 C  CB  A GLU C 1 6   ? -12.191 9.144   27.247  0.5  76.6   ? 2   GLU C CB  1 
ATOM   4563 C  CB  B GLU C 1 6   ? -12.311 8.782   26.824  0.5  71     ? 2   GLU C CB  1 
ATOM   4564 C  CG  A GLU C 1 6   ? -11.116 9.836   28.09   0.5  80.84  ? 2   GLU C CG  1 
ATOM   4565 C  CG  B GLU C 1 6   ? -11.859 7.771   27.878  0.5  72.77  ? 2   GLU C CG  1 
ATOM   4566 C  CD  A GLU C 1 6   ? -10.477 11.092  27.521  0.5  82.99  ? 2   GLU C CD  1 
ATOM   4567 C  CD  B GLU C 1 6   ? -10.447 7.212   27.694  0.5  71.61  ? 2   GLU C CD  1 
ATOM   4568 O  OE1 A GLU C 1 6   ? -9.94   11.017  26.397  0.5  83.76  ? 2   GLU C OE1 1 
ATOM   4569 O  OE1 B GLU C 1 6   ? -10.165 6.66    26.621  0.5  71.27  ? 2   GLU C OE1 1 
ATOM   4570 O  OE2 A GLU C 1 6   ? -10.514 12.146  28.19   0.5  82.82  ? 2   GLU C OE2 1 
ATOM   4571 O  OE2 B GLU C 1 6   ? -9.619  7.311   28.616  0.5  70.85  ? 2   GLU C OE2 1 
ATOM   4572 N  N   . ASN C 1 7   ? -14.934 9.965   25.278  1    63.44  ? 3   ASN C N   1 
ATOM   4573 C  CA  . ASN C 1 7   ? -15.441 10.66   24.101  1    59.72  ? 3   ASN C CA  1 
ATOM   4574 C  C   . ASN C 1 7   ? -16.365 11.822  24.466  1    57.88  ? 3   ASN C C   1 
ATOM   4575 O  O   . ASN C 1 7   ? -16.656 12.653  23.61   1    59.29  ? 3   ASN C O   1 
ATOM   4576 C  CB  . ASN C 1 7   ? -16.129 9.728   23.11   1    57.2   ? 3   ASN C CB  1 
ATOM   4577 C  CG  . ASN C 1 7   ? -15.166 8.743   22.49   1    56.96  ? 3   ASN C CG  1 
ATOM   4578 O  OD1 . ASN C 1 7   ? -13.969 9.025   22.353  1    58.43  ? 3   ASN C OD1 1 
ATOM   4579 N  ND2 . ASN C 1 7   ? -15.666 7.567   22.155  1    53.56  ? 3   ASN C ND2 1 
ATOM   4580 N  N   . PHE C 1 8   ? -16.84  11.866  25.716  1    53.98  ? 4   PHE C N   1 
ATOM   4581 C  CA  . PHE C 1 8   ? -17.781 12.889  26.139  1    52.76  ? 4   PHE C CA  1 
ATOM   4582 C  C   . PHE C 1 8   ? -17.053 14.022  26.853  1    56.53  ? 4   PHE C C   1 
ATOM   4583 O  O   . PHE C 1 8   ? -16.213 13.782  27.706  1    63.24  ? 4   PHE C O   1 
ATOM   4584 C  CB  . PHE C 1 8   ? -18.892 12.268  26.985  1    49.67  ? 4   PHE C CB  1 
ATOM   4585 C  CG  . PHE C 1 8   ? -19.812 11.422  26.134  1    48.52  ? 4   PHE C CG  1 
ATOM   4586 C  CD1 . PHE C 1 8   ? -20.626 12.015  25.178  1    46.3   ? 4   PHE C CD1 1 
ATOM   4587 C  CD2 . PHE C 1 8   ? -19.837 10.037  26.265  1    52.24  ? 4   PHE C CD2 1 
ATOM   4588 C  CE1 . PHE C 1 8   ? -21.425 11.244  24.345  1    47.73  ? 4   PHE C CE1 1 
ATOM   4589 C  CE2 . PHE C 1 8   ? -20.661 9.266   25.443  1    52.38  ? 4   PHE C CE2 1 
ATOM   4590 C  CZ  . PHE C 1 8   ? -21.447 9.871   24.479  1    49.77  ? 4   PHE C CZ  1 
ATOM   4591 N  N   . GLN C 1 9   ? -17.387 15.258  26.482  1    58.56  ? 5   GLN C N   1 
ATOM   4592 C  CA  . GLN C 1 9   ? -16.878 16.459  27.129  1    60.45  ? 5   GLN C CA  1 
ATOM   4593 C  C   . GLN C 1 9   ? -18.043 17.139  27.849  1    58.26  ? 5   GLN C C   1 
ATOM   4594 O  O   . GLN C 1 9   ? -19.078 17.432  27.244  1    58.53  ? 5   GLN C O   1 
ATOM   4595 C  CB  . GLN C 1 9   ? -16.292 17.366  26.049  1    64.91  ? 5   GLN C CB  1 
ATOM   4596 C  CG  . GLN C 1 9   ? -15.909 18.758  26.523  1    78     ? 5   GLN C CG  1 
ATOM   4597 C  CD  . GLN C 1 9   ? -14.634 18.746  27.335  1    90.99  ? 5   GLN C CD  1 
ATOM   4598 O  OE1 . GLN C 1 9   ? -13.618 18.194  26.885  1    91.59  ? 5   GLN C OE1 1 
ATOM   4599 N  NE2 . GLN C 1 9   ? -14.663 19.371  28.511  1    91.59  ? 5   GLN C NE2 1 
ATOM   4600 N  N   . LYS C 1 10  ? -17.876 17.367  29.152  1    55.36  ? 6   LYS C N   1 
ATOM   4601 C  CA  . LYS C 1 10  ? -18.868 18.094  29.936  1    55.58  ? 6   LYS C CA  1 
ATOM   4602 C  C   . LYS C 1 10  ? -18.989 19.537  29.439  1    54.96  ? 6   LYS C C   1 
ATOM   4603 O  O   . LYS C 1 10  ? -17.989 20.158  29.096  1    55.28  ? 6   LYS C O   1 
ATOM   4604 C  CB  . LYS C 1 10  ? -18.364 18.182  31.382  1    59.67  ? 6   LYS C CB  1 
ATOM   4605 C  CG  . LYS C 1 10  ? -19.367 18.742  32.396  1    64.67  ? 6   LYS C CG  1 
ATOM   4606 C  CD  . LYS C 1 10  ? -18.769 19.1    33.75   1    69.82  ? 6   LYS C CD  1 
ATOM   4607 C  CE  . LYS C 1 10  ? -17.84  20.283  33.606  1    74.96  ? 6   LYS C CE  1 
ATOM   4608 N  NZ  . LYS C 1 10  ? -17.041 20.574  34.795  1    75.06  ? 6   LYS C NZ  1 
ATOM   4609 N  N   . VAL C 1 11  ? -20.215 20.066  29.428  1    53.5   ? 7   VAL C N   1 
ATOM   4610 C  CA  . VAL C 1 11  ? -20.473 21.464  29.112  1    54.99  ? 7   VAL C CA  1 
ATOM   4611 C  C   . VAL C 1 11  ? -21.028 22.127  30.376  1    56.19  ? 7   VAL C C   1 
ATOM   4612 O  O   . VAL C 1 11  ? -20.409 23.022  30.914  1    60.35  ? 7   VAL C O   1 
ATOM   4613 C  CB  . VAL C 1 11  ? -21.407 21.615  27.888  1    53.27  ? 7   VAL C CB  1 
ATOM   4614 C  CG1 . VAL C 1 11  ? -21.612 23.052  27.477  1    51.83  ? 7   VAL C CG1 1 
ATOM   4615 C  CG2 . VAL C 1 11  ? -20.923 20.799  26.692  1    49.57  ? 7   VAL C CG2 1 
ATOM   4616 N  N   . GLU C 1 12  ? -22.16  21.659  30.909  1    56.47  ? 8   GLU C N   1 
ATOM   4617 C  CA  . GLU C 1 12  ? -22.724 22.256  32.11   1    59.33  ? 8   GLU C CA  1 
ATOM   4618 C  C   . GLU C 1 12  ? -23.78  21.327  32.703  1    61.65  ? 8   GLU C C   1 
ATOM   4619 O  O   . GLU C 1 12  ? -24.308 20.474  31.976  1    60.35  ? 8   GLU C O   1 
ATOM   4620 C  CB  . GLU C 1 12  ? -23.367 23.602  31.776  1    60.54  ? 8   GLU C CB  1 
ATOM   4621 C  CG  . GLU C 1 12  ? -24.546 23.477  30.819  1    62.93  ? 8   GLU C CG  1 
ATOM   4622 C  CD  . GLU C 1 12  ? -24.944 24.741  30.083  1    70.12  ? 8   GLU C CD  1 
ATOM   4623 O  OE1 . GLU C 1 12  ? -24.025 25.482  29.653  1    74.03  ? 8   GLU C OE1 1 
ATOM   4624 O  OE2 . GLU C 1 12  ? -26.173 24.954  29.92   1    71.2   ? 8   GLU C OE2 1 
ATOM   4625 N  N   . LYS C 1 13  ? -24.076 21.5    34.013  1    62.14  ? 9   LYS C N   1 
ATOM   4626 C  CA  . LYS C 1 13  ? -25.095 20.696  34.681  1    62.56  ? 9   LYS C CA  1 
ATOM   4627 C  C   . LYS C 1 13  ? -26.468 21.165  34.215  1    57.79  ? 9   LYS C C   1 
ATOM   4628 O  O   . LYS C 1 13  ? -26.63  22.349  33.94   1    62.88  ? 9   LYS C O   1 
ATOM   4629 C  CB  . LYS C 1 13  ? -24.935 20.789  36.201  1    73.67  ? 9   LYS C CB  1 
ATOM   4630 C  CG  . LYS C 1 13  ? -25.686 19.705  36.992  1    84.72  ? 9   LYS C CG  1 
ATOM   4631 C  CD  . LYS C 1 13  ? -25.588 19.873  38.506  1    89.92  ? 9   LYS C CD  1 
ATOM   4632 C  CE  . LYS C 1 13  ? -26.854 19.426  39.183  1    99.55  ? 9   LYS C CE  1 
ATOM   4633 N  NZ  . LYS C 1 13  ? -26.652 19.462  40.636  1    103.44 ? 9   LYS C NZ  1 
ATOM   4634 N  N   . ILE C 1 14  ? -27.429 20.248  34.076  1    54.05  ? 10  ILE C N   1 
ATOM   4635 C  CA  . ILE C 1 14  ? -28.751 20.657  33.623  1    59.02  ? 10  ILE C CA  1 
ATOM   4636 C  C   . ILE C 1 14  ? -29.872 20.151  34.536  1    66.13  ? 10  ILE C C   1 
ATOM   4637 O  O   . ILE C 1 14  ? -31.02  20.547  34.371  1    68.15  ? 10  ILE C O   1 
ATOM   4638 C  CB  . ILE C 1 14  ? -29.016 20.401  32.12   1    55.66  ? 10  ILE C CB  1 
ATOM   4639 C  CG1 . ILE C 1 14  ? -29.089 18.951  31.741  1    53.32  ? 10  ILE C CG1 1 
ATOM   4640 C  CG2 . ILE C 1 14  ? -28.018 21.152  31.246  1    57.67  ? 10  ILE C CG2 1 
ATOM   4641 C  CD1 . ILE C 1 14  ? -29.152 18.724  30.238  1    47.8   ? 10  ILE C CD1 1 
ATOM   4642 N  N   . GLY C 1 15  ? -29.558 19.332  35.543  1    70.41  ? 11  GLY C N   1 
ATOM   4643 C  CA  . GLY C 1 15  ? -30.612 18.98   36.483  1    74.54  ? 11  GLY C CA  1 
ATOM   4644 C  C   . GLY C 1 15  ? -30.158 17.933  37.485  1    81.44  ? 11  GLY C C   1 
ATOM   4645 O  O   . GLY C 1 15  ? -28.994 17.545  37.453  1    78.45  ? 11  GLY C O   1 
ATOM   4646 N  N   . GLU C 1 16  ? -31.086 17.519  38.366  1    86.37  ? 12  GLU C N   1 
ATOM   4647 C  CA  . GLU C 1 16  ? -30.761 16.605  39.455  1    91.08  ? 12  GLU C CA  1 
ATOM   4648 C  C   . GLU C 1 16  ? -32.027 15.939  39.994  1    101.05 ? 12  GLU C C   1 
ATOM   4649 O  O   . GLU C 1 16  ? -33.09  16.554  39.957  1    103.76 ? 12  GLU C O   1 
ATOM   4650 C  CB  . GLU C 1 16  ? -29.953 17.28   40.566  1    76.43  ? 12  GLU C CB  1 
ATOM   4651 C  CG  . GLU C 1 16  ? -28.976 16.295  41.192  1    85.73  ? 12  GLU C CG  1 
ATOM   4652 C  CD  . GLU C 1 16  ? -28.097 16.833  42.31   1    102.1  ? 12  GLU C CD  1 
ATOM   4653 O  OE1 . GLU C 1 16  ? -27.351 16.045  42.95   1    98.15  ? 12  GLU C OE1 1 
ATOM   4654 O  OE2 . GLU C 1 16  ? -28.155 18.062  42.532  1    104.13 ? 12  GLU C OE2 1 
ATOM   4655 N  N   . GLY C 1 17  ? -31.887 14.676  40.458  1    113.2  ? 13  GLY C N   1 
ATOM   4656 C  CA  . GLY C 1 17  ? -32.873 13.912  41.224  1    104.87 ? 13  GLY C CA  1 
ATOM   4657 C  C   . GLY C 1 17  ? -32.211 13.227  42.427  1    104.1  ? 13  GLY C C   1 
ATOM   4658 O  O   . GLY C 1 17  ? -31.061 13.523  42.742  1    103.62 ? 13  GLY C O   1 
ATOM   4659 N  N   . THR C 1 18  ? -32.906 12.303  43.11   1    117.18 ? 14  THR C N   1 
ATOM   4660 C  CA  . THR C 1 18  ? -32.208 11.481  44.104  1    123.67 ? 14  THR C CA  1 
ATOM   4661 C  C   . THR C 1 18  ? -31.441 10.368  43.392  1    120.68 ? 14  THR C C   1 
ATOM   4662 O  O   . THR C 1 18  ? -30.42  9.899   43.894  1    118.03 ? 14  THR C O   1 
ATOM   4663 C  CB  . THR C 1 18  ? -33.083 10.905  45.228  1    117.98 ? 14  THR C CB  1 
ATOM   4664 O  OG1 . THR C 1 18  ? -34.211 10.369  44.535  1    109.6  ? 14  THR C OG1 1 
ATOM   4665 C  CG2 . THR C 1 18  ? -33.335 11.862  46.391  1    95.27  ? 14  THR C CG2 1 
ATOM   4666 N  N   . TYR C 1 19  ? -31.951 9.957   42.22   1    129.09 ? 15  TYR C N   1 
ATOM   4667 C  CA  . TYR C 1 19  ? -31.387 8.837   41.478  1    132.61 ? 15  TYR C CA  1 
ATOM   4668 C  C   . TYR C 1 19  ? -30.514 9.305   40.313  1    130.62 ? 15  TYR C C   1 
ATOM   4669 O  O   . TYR C 1 19  ? -29.742 8.509   39.781  1    155.33 ? 15  TYR C O   1 
ATOM   4670 C  CB  . TYR C 1 19  ? -32.434 7.765   41.15   1    117.19 ? 15  TYR C CB  1 
ATOM   4671 C  CG  . TYR C 1 19  ? -32.781 6.868   42.337  1    118.5  ? 15  TYR C CG  1 
ATOM   4672 C  CD1 . TYR C 1 19  ? -31.788 6.177   43.041  1    114.38 ? 15  TYR C CD1 1 
ATOM   4673 C  CD2 . TYR C 1 19  ? -34.1   6.767   42.8    1    110.64 ? 15  TYR C CD2 1 
ATOM   4674 C  CE1 . TYR C 1 19  ? -32.104 5.386   44.138  1    122.42 ? 15  TYR C CE1 1 
ATOM   4675 C  CE2 . TYR C 1 19  ? -34.428 5.971   43.891  1    113.97 ? 15  TYR C CE2 1 
ATOM   4676 C  CZ  . TYR C 1 19  ? -33.424 5.279   44.564  1    128.45 ? 15  TYR C CZ  1 
ATOM   4677 O  OH  . TYR C 1 19  ? -33.72  4.488   45.654  1    115.69 ? 15  TYR C OH  1 
ATOM   4678 N  N   . GLY C 1 20  ? -30.584 10.598  39.962  1    110.4  ? 16  GLY C N   1 
ATOM   4679 C  CA  . GLY C 1 20  ? -29.806 11.086  38.834  1    100.97 ? 16  GLY C CA  1 
ATOM   4680 C  C   . GLY C 1 20  ? -29.143 12.441  39.084  1    97.33  ? 16  GLY C C   1 
ATOM   4681 O  O   . GLY C 1 20  ? -29.592 13.244  39.897  1    92.65  ? 16  GLY C O   1 
ATOM   4682 N  N   . VAL C 1 21  ? -28.044 12.668  38.366  1    88.85  ? 17  VAL C N   1 
ATOM   4683 C  CA  . VAL C 1 21  ? -27.596 14.005  38.016  1    75.53  ? 17  VAL C CA  1 
ATOM   4684 C  C   . VAL C 1 21  ? -27.49  14.033  36.48   1    68.81  ? 17  VAL C C   1 
ATOM   4685 O  O   . VAL C 1 21  ? -27.097 13.045  35.879  1    61.91  ? 17  VAL C O   1 
ATOM   4686 C  CB  . VAL C 1 21  ? -26.295 14.353  38.77   1    69.76  ? 17  VAL C CB  1 
ATOM   4687 C  CG1 . VAL C 1 21  ? -25.127 13.437  38.39   1    71.37  ? 17  VAL C CG1 1 
ATOM   4688 C  CG2 . VAL C 1 21  ? -25.903 15.815  38.622  1    66.73  ? 17  VAL C CG2 1 
ATOM   4689 N  N   . VAL C 1 22  ? -27.912 15.129  35.833  1    59.92  ? 18  VAL C N   1 
ATOM   4690 C  CA  . VAL C 1 22  ? -27.935 15.218  34.381  1    52.98  ? 18  VAL C CA  1 
ATOM   4691 C  C   . VAL C 1 22  ? -27.052 16.386  33.941  1    57.79  ? 18  VAL C C   1 
ATOM   4692 O  O   . VAL C 1 22  ? -27.184 17.513  34.456  1    58.59  ? 18  VAL C O   1 
ATOM   4693 C  CB  . VAL C 1 22  ? -29.368 15.388  33.832  1    52.34  ? 18  VAL C CB  1 
ATOM   4694 C  CG1 . VAL C 1 22  ? -29.424 15.155  32.334  1    47.68  ? 18  VAL C CG1 1 
ATOM   4695 C  CG2 . VAL C 1 22  ? -30.367 14.467  34.511  1    52.87  ? 18  VAL C CG2 1 
ATOM   4696 N  N   . TYR C 1 23  ? -26.154 16.101  32.978  1    53.9   ? 19  TYR C N   1 
ATOM   4697 C  CA  . TYR C 1 23  ? -25.266 17.1    32.401  1    51.72  ? 19  TYR C CA  1 
ATOM   4698 C  C   . TYR C 1 23  ? -25.475 17.17   30.894  1    48.77  ? 19  TYR C C   1 
ATOM   4699 O  O   . TYR C 1 23  ? -25.683 16.161  30.23   1    44.02  ? 19  TYR C O   1 
ATOM   4700 C  CB  . TYR C 1 23  ? -23.792 16.782  32.64   1    50.41  ? 19  TYR C CB  1 
ATOM   4701 C  CG  . TYR C 1 23  ? -23.289 17.084  34.036  1    55.93  ? 19  TYR C CG  1 
ATOM   4702 C  CD1 . TYR C 1 23  ? -23.582 16.246  35.111  1    59.74  ? 19  TYR C CD1 1 
ATOM   4703 C  CD2 . TYR C 1 23  ? -22.457 18.176  34.261  1    59.06  ? 19  TYR C CD2 1 
ATOM   4704 C  CE1 . TYR C 1 23  ? -23.097 16.508  36.385  1    64.97  ? 19  TYR C CE1 1 
ATOM   4705 C  CE2 . TYR C 1 23  ? -21.962 18.447  35.526  1    68.02  ? 19  TYR C CE2 1 
ATOM   4706 C  CZ  . TYR C 1 23  ? -22.284 17.616  36.59   1    70.53  ? 19  TYR C CZ  1 
ATOM   4707 O  OH  . TYR C 1 23  ? -21.763 17.932  37.812  1    76.78  ? 19  TYR C OH  1 
ATOM   4708 N  N   . LYS C 1 24  ? -25.38  18.389  30.366  1    48.58  ? 20  LYS C N   1 
ATOM   4709 C  CA  . LYS C 1 24  ? -25.151 18.572  28.947  1    46.93  ? 20  LYS C CA  1 
ATOM   4710 C  C   . LYS C 1 24  ? -23.694 18.237  28.646  1    47.26  ? 20  LYS C C   1 
ATOM   4711 O  O   . LYS C 1 24  ? -22.793 18.534  29.418  1    46.47  ? 20  LYS C O   1 
ATOM   4712 C  CB  . LYS C 1 24  ? -25.425 20.03   28.6    1    47.89  ? 20  LYS C CB  1 
ATOM   4713 C  CG  . LYS C 1 24  ? -25.178 20.425  27.159  1    51.68  ? 20  LYS C CG  1 
ATOM   4714 C  CD  . LYS C 1 24  ? -25.59  21.874  26.903  1    51.97  ? 20  LYS C CD  1 
ATOM   4715 C  CE  . LYS C 1 24  ? -25.425 22.224  25.471  1    55.58  ? 20  LYS C CE  1 
ATOM   4716 N  NZ  . LYS C 1 24  ? -25.794 23.611  25.226  1    60.96  ? 20  LYS C NZ  1 
ATOM   4717 N  N   . ALA C 1 25  ? -23.473 17.586  27.509  1    47.81  ? 21  ALA C N   1 
ATOM   4718 C  CA  . ALA C 1 25  ? -22.148 17.128  27.143  1    48.75  ? 21  ALA C CA  1 
ATOM   4719 C  C   . ALA C 1 25  ? -22.056 17.05   25.621  1    49.14  ? 21  ALA C C   1 
ATOM   4720 O  O   . ALA C 1 25  ? -23.09  17.052  24.932  1    48.24  ? 21  ALA C O   1 
ATOM   4721 C  CB  . ALA C 1 25  ? -21.903 15.777  27.785  1    48.8   ? 21  ALA C CB  1 
ATOM   4722 N  N   . ARG C 1 26  ? -20.817 16.937  25.127  1    46.78  ? 22  ARG C N   1 
ATOM   4723 C  CA  . ARG C 1 26  ? -20.522 16.93   23.706  1    47.88  ? 22  ARG C CA  1 
ATOM   4724 C  C   . ARG C 1 26  ? -19.74  15.663  23.373  1    47.91  ? 22  ARG C C   1 
ATOM   4725 O  O   . ARG C 1 26  ? -18.757 15.337  24.05   1    48.54  ? 22  ARG C O   1 
ATOM   4726 C  CB  . ARG C 1 26  ? -19.668 18.152  23.347  1    53.71  ? 22  ARG C CB  1 
ATOM   4727 C  CG  . ARG C 1 26  ? -19.794 18.6    21.9    1    66.44  ? 22  ARG C CG  1 
ATOM   4728 C  CD  . ARG C 1 26  ? -18.974 19.877  21.592  1    75.01  ? 22  ARG C CD  1 
ATOM   4729 N  NE  . ARG C 1 26  ? -17.625 19.447  21.191  1    82.59  ? 22  ARG C NE  1 
ATOM   4730 C  CZ  . ARG C 1 26  ? -16.548 19.428  21.985  1    81.54  ? 22  ARG C CZ  1 
ATOM   4731 N  NH1 . ARG C 1 26  ? -16.611 19.933  23.207  1    77.09  ? 22  ARG C NH1 1 
ATOM   4732 N  NH2 . ARG C 1 26  ? -15.412 18.91   21.547  1    78.95  ? 22  ARG C NH2 1 
ATOM   4733 N  N   . ASN C 1 27  ? -20.179 14.96   22.317  1    45.38  ? 23  ASN C N   1 
ATOM   4734 C  CA  . ASN C 1 27  ? -19.409 13.881  21.732  1    44.52  ? 23  ASN C CA  1 
ATOM   4735 C  C   . ASN C 1 27  ? -18.239 14.489  20.958  1    47.89  ? 23  ASN C C   1 
ATOM   4736 O  O   . ASN C 1 27  ? -18.443 15.215  19.995  1    48.37  ? 23  ASN C O   1 
ATOM   4737 C  CB  . ASN C 1 27  ? -20.275 13.038  20.807  1    42.95  ? 23  ASN C CB  1 
ATOM   4738 C  CG  . ASN C 1 27  ? -19.614 11.726  20.431  1    44.23  ? 23  ASN C CG  1 
ATOM   4739 O  OD1 . ASN C 1 27  ? -18.501 11.703  19.879  1    44.34  ? 23  ASN C OD1 1 
ATOM   4740 N  ND2 . ASN C 1 27  ? -20.277 10.617  20.732  1    41.67  ? 23  ASN C ND2 1 
ATOM   4741 N  N   . LYS C 1 28  ? -17.006 14.208  21.384  1    50.51  ? 24  LYS C N   1 
ATOM   4742 C  CA  . LYS C 1 28  ? -15.86  14.867  20.804  1    56.5   ? 24  LYS C CA  1 
ATOM   4743 C  C   . LYS C 1 28  ? -15.613 14.359  19.385  1    57.35  ? 24  LYS C C   1 
ATOM   4744 O  O   . LYS C 1 28  ? -14.939 15.022  18.585  1    58.68  ? 24  LYS C O   1 
ATOM   4745 C  CB  . LYS C 1 28  ? -14.609 14.584  21.639  1    66.77  ? 24  LYS C CB  1 
ATOM   4746 C  CG  . LYS C 1 28  ? -14.533 15.183  23.028  1    75.37  ? 24  LYS C CG  1 
ATOM   4747 C  CD  . LYS C 1 28  ? -13.279 14.766  23.802  1    81.28  ? 24  LYS C CD  1 
ATOM   4748 C  CE  . LYS C 1 28  ? -13.532 14.692  25.296  1    88.62  ? 24  LYS C CE  1 
ATOM   4749 N  NZ  . LYS C 1 28  ? -12.372 14.236  26.076  1    88.37  ? 24  LYS C NZ  1 
ATOM   4750 N  N   . LEU C 1 29  ? -16.111 13.157  19.09   1    54.71  ? 25  LEU C N   1 
ATOM   4751 C  CA  . LEU C 1 29  ? -15.835 12.544  17.799  1    54.83  ? 25  LEU C CA  1 
ATOM   4752 C  C   . LEU C 1 29  ? -16.907 12.935  16.779  1    54.19  ? 25  LEU C C   1 
ATOM   4753 O  O   . LEU C 1 29  ? -16.558 13.15   15.626  1    59.61  ? 25  LEU C O   1 
ATOM   4754 C  CB  . LEU C 1 29  ? -15.695 11.028  17.959  1    52.95  ? 25  LEU C CB  1 
ATOM   4755 C  CG  . LEU C 1 29  ? -14.377 10.547  18.57   1    51.06  ? 25  LEU C CG  1 
ATOM   4756 C  CD1 . LEU C 1 29  ? -14.429 9.057   18.867  1    49.05  ? 25  LEU C CD1 1 
ATOM   4757 C  CD2 . LEU C 1 29  ? -13.247 10.872  17.629  1    50.94  ? 25  LEU C CD2 1 
ATOM   4758 N  N   . THR C 1 30  ? -18.179 13.035  17.206  1    49.76  ? 26  THR C N   1 
ATOM   4759 C  CA  . THR C 1 30  ? -19.291 13.295  16.311  1    49.69  ? 26  THR C CA  1 
ATOM   4760 C  C   . THR C 1 30  ? -19.785 14.742  16.383  1    50.46  ? 26  THR C C   1 
ATOM   4761 O  O   . THR C 1 30  ? -20.429 15.23   15.453  1    52.01  ? 26  THR C O   1 
ATOM   4762 C  CB  . THR C 1 30  ? -20.437 12.315  16.542  1    48.2   ? 26  THR C CB  1 
ATOM   4763 O  OG1 . THR C 1 30  ? -21.03  12.561  17.816  1    47.58  ? 26  THR C OG1 1 
ATOM   4764 C  CG2 . THR C 1 30  ? -19.99  10.868  16.426  1    47.95  ? 26  THR C CG2 1 
ATOM   4765 N  N   . GLY C 1 31  ? -19.551 15.434  17.497  1    49.77  ? 27  GLY C N   1 
ATOM   4766 C  CA  . GLY C 1 31  ? -20.1   16.776  17.644  1    49.24  ? 27  GLY C CA  1 
ATOM   4767 C  C   . GLY C 1 31  ? -21.526 16.785  18.194  1    49.54  ? 27  GLY C C   1 
ATOM   4768 O  O   . GLY C 1 31  ? -22.083 17.849  18.464  1    52.17  ? 27  GLY C O   1 
ATOM   4769 N  N   . GLU C 1 32  ? -22.128 15.603  18.341  1    46.86  ? 28  GLU C N   1 
ATOM   4770 C  CA  . GLU C 1 32  ? -23.463 15.515  18.896  1    47.57  ? 28  GLU C CA  1 
ATOM   4771 C  C   . GLU C 1 32  ? -23.421 16.023  20.335  1    48.27  ? 28  GLU C C   1 
ATOM   4772 O  O   . GLU C 1 32  ? -22.491 15.726  21.083  1    47.68  ? 28  GLU C O   1 
ATOM   4773 C  CB  . GLU C 1 32  ? -23.958 14.066  18.788  1    48.84  ? 28  GLU C CB  1 
ATOM   4774 C  CG  . GLU C 1 32  ? -25.354 13.816  19.362  1    45.62  ? 28  GLU C CG  1 
ATOM   4775 C  CD  . GLU C 1 32  ? -25.729 12.343  19.366  1    48.69  ? 28  GLU C CD  1 
ATOM   4776 O  OE1 . GLU C 1 32  ? -24.827 11.468  19.546  1    50.92  ? 28  GLU C OE1 1 
ATOM   4777 O  OE2 . GLU C 1 32  ? -26.944 12.059  19.234  1    48.96  ? 28  GLU C OE2 1 
ATOM   4778 N  N   . VAL C 1 33  ? -24.433 16.821  20.684  1    48.19  ? 29  VAL C N   1 
ATOM   4779 C  CA  . VAL C 1 33  ? -24.632 17.34   22.027  1    44.75  ? 29  VAL C CA  1 
ATOM   4780 C  C   . VAL C 1 33  ? -25.69  16.435  22.648  1    43.16  ? 29  VAL C C   1 
ATOM   4781 O  O   . VAL C 1 33  ? -26.669 16.092  21.993  1    43.46  ? 29  VAL C O   1 
ATOM   4782 C  CB  . VAL C 1 33  ? -25.053 18.83   21.997  1    44.07  ? 29  VAL C CB  1 
ATOM   4783 C  CG1 . VAL C 1 33  ? -25.367 19.369  23.393  1    41.33  ? 29  VAL C CG1 1 
ATOM   4784 C  CG2 . VAL C 1 33  ? -24.017 19.708  21.284  1    42.92  ? 29  VAL C CG2 1 
ATOM   4785 N  N   . VAL C 1 34  ? -25.47  16.017  23.891  1    41.34  ? 30  VAL C N   1 
ATOM   4786 C  CA  . VAL C 1 34  ? -26.337 15.034  24.522  1    41.03  ? 30  VAL C CA  1 
ATOM   4787 C  C   . VAL C 1 34  ? -26.62  15.494  25.952  1    43.33  ? 30  VAL C C   1 
ATOM   4788 O  O   . VAL C 1 34  ? -25.994 16.436  26.452  1    48.33  ? 30  VAL C O   1 
ATOM   4789 C  CB  . VAL C 1 34  ? -25.694 13.63   24.529  1    38.59  ? 30  VAL C CB  1 
ATOM   4790 C  CG1 . VAL C 1 34  ? -25.346 13.135  23.132  1    37.45  ? 30  VAL C CG1 1 
ATOM   4791 C  CG2 . VAL C 1 34  ? -24.479 13.562  25.434  1    37.44  ? 30  VAL C CG2 1 
ATOM   4792 N  N   . ALA C 1 35  ? -27.568 14.819  26.601  1    41.59  ? 31  ALA C N   1 
ATOM   4793 C  CA  . ALA C 1 35  ? -27.753 14.914  28.038  1    42.09  ? 31  ALA C CA  1 
ATOM   4794 C  C   . ALA C 1 35  ? -27.37  13.558  28.607  1    43.33  ? 31  ALA C C   1 
ATOM   4795 O  O   . ALA C 1 35  ? -27.957 12.55   28.209  1    45.8   ? 31  ALA C O   1 
ATOM   4796 C  CB  . ALA C 1 35  ? -29.211 15.235  28.327  1    40.49  ? 31  ALA C CB  1 
ATOM   4797 N  N   . LEU C 1 36  ? -26.34  13.526  29.453  1    46     ? 32  LEU C N   1 
ATOM   4798 C  CA  . LEU C 1 36  ? -25.921 12.315  30.155  1    48.89  ? 32  LEU C CA  1 
ATOM   4799 C  C   . LEU C 1 36  ? -26.614 12.256  31.511  1    47.44  ? 32  LEU C C   1 
ATOM   4800 O  O   . LEU C 1 36  ? -26.502 13.199  32.284  1    50.58  ? 32  LEU C O   1 
ATOM   4801 C  CB  . LEU C 1 36  ? -24.41  12.35   30.375  1    49.54  ? 32  LEU C CB  1 
ATOM   4802 C  CG  . LEU C 1 36  ? -23.541 12.267  29.127  1    55.58  ? 32  LEU C CG  1 
ATOM   4803 C  CD1 . LEU C 1 36  ? -22.09  12.296  29.546  1    54.22  ? 32  LEU C CD1 1 
ATOM   4804 C  CD2 . LEU C 1 36  ? -23.841 10.985  28.362  1    59.29  ? 32  LEU C CD2 1 
ATOM   4805 N  N   . LYS C 1 37  ? -27.301 11.157  31.816  1    47.1   ? 33  LYS C N   1 
ATOM   4806 C  CA  . LYS C 1 37  ? -27.839 10.967  33.162  1    47.83  ? 33  LYS C CA  1 
ATOM   4807 C  C   . LYS C 1 37  ? -26.975 9.925   33.862  1    49.13  ? 33  LYS C C   1 
ATOM   4808 O  O   . LYS C 1 37  ? -26.893 8.789   33.395  1    53.07  ? 33  LYS C O   1 
ATOM   4809 C  CB  . LYS C 1 37  ? -29.318 10.56   33.102  1    47.42  ? 33  LYS C CB  1 
ATOM   4810 C  CG  . LYS C 1 37  ? -30.005 10.491  34.452  1    49.63  ? 33  LYS C CG  1 
ATOM   4811 C  CD  . LYS C 1 37  ? -31.451 10.011  34.514  1    49.25  ? 33  LYS C CD  1 
ATOM   4812 C  CE  . LYS C 1 37  ? -32.402 10.893  33.784  1    49.74  ? 33  LYS C CE  1 
ATOM   4813 N  NZ  . LYS C 1 37  ? -33.781 10.44   33.974  1    54.23  ? 33  LYS C NZ  1 
ATOM   4814 N  N   . LYS C 1 38  ? -26.261 10.34   34.914  1    50.4   ? 34  LYS C N   1 
ATOM   4815 C  CA  . LYS C 1 38  ? -25.492 9.425   35.746  1    51.4   ? 34  LYS C CA  1 
ATOM   4816 C  C   . LYS C 1 38  ? -26.406 8.912   36.846  1    51.74  ? 34  LYS C C   1 
ATOM   4817 O  O   . LYS C 1 38  ? -27.041 9.719   37.535  1    55.84  ? 34  LYS C O   1 
ATOM   4818 C  CB  . LYS C 1 38  ? -24.275 10.074  36.413  1    55.77  ? 34  LYS C CB  1 
ATOM   4819 C  CG  . LYS C 1 38  ? -23.403 9.083   37.175  1    65.33  ? 34  LYS C CG  1 
ATOM   4820 C  CD  . LYS C 1 38  ? -22.237 9.627   37.999  1    74.18  ? 34  LYS C CD  1 
ATOM   4821 C  CE  . LYS C 1 38  ? -22.541 10.172  39.361  1    83.64  ? 34  LYS C CE  1 
ATOM   4822 N  NZ  . LYS C 1 38  ? -21.275 10.618  39.964  1    94.72  ? 34  LYS C NZ  1 
ATOM   4823 N  N   . ILE C 1 39  ? -26.516 7.574   36.941  1    53.41  ? 35  ILE C N   1 
ATOM   4824 C  CA  . ILE C 1 39  ? -27.292 6.892   37.972  1    55.25  ? 35  ILE C CA  1 
ATOM   4825 C  C   . ILE C 1 39  ? -26.33  6.11    38.85   1    56.2   ? 35  ILE C C   1 
ATOM   4826 O  O   . ILE C 1 39  ? -25.652 5.194   38.371  1    58.37  ? 35  ILE C O   1 
ATOM   4827 C  CB  . ILE C 1 39  ? -28.351 5.958   37.363  1    54.2   ? 35  ILE C CB  1 
ATOM   4828 C  CG1 . ILE C 1 39  ? -29.406 6.74    36.623  1    55.3   ? 35  ILE C CG1 1 
ATOM   4829 C  CG2 . ILE C 1 39  ? -28.977 5.095   38.46   1    51.67  ? 35  ILE C CG2 1 
ATOM   4830 C  CD1 . ILE C 1 39  ? -30.234 5.877   35.705  1    61.85  ? 35  ILE C CD1 1 
ATOM   4831 N  N   . ARG C 1 40  ? -26.289 6.49    40.111  1    66.85  ? 36  ARG C N   1 
ATOM   4832 C  CA  . ARG C 1 40  ? -25.358 5.841   41.058  1    77.46  ? 36  ARG C CA  1 
ATOM   4833 C  C   . ARG C 1 40  ? -25.917 4.49    41.487  1    68.17  ? 36  ARG C C   1 
ATOM   4834 O  O   . ARG C 1 40  ? -27.07  4.432   41.945  1    63.56  ? 36  ARG C O   1 
ATOM   4835 C  CB  . ARG C 1 40  ? -25.139 6.746   42.271  1    90.97  ? 36  ARG C CB  1 
ATOM   4836 C  CG  . ARG C 1 40  ? -24.356 8.012   41.963  1    112.26 ? 36  ARG C CG  1 
ATOM   4837 C  CD  . ARG C 1 40  ? -23.9   8.702   43.238  1    130.99 ? 36  ARG C CD  1 
ATOM   4838 N  NE  . ARG C 1 40  ? -25.022 9.154   44.066  1    134.72 ? 36  ARG C NE  1 
ATOM   4839 C  CZ  . ARG C 1 40  ? -25.639 10.317  43.915  1    125.68 ? 36  ARG C CZ  1 
ATOM   4840 N  NH1 . ARG C 1 40  ? -24.934 11.419  43.736  1    116.9  ? 36  ARG C NH1 1 
ATOM   4841 N  NH2 . ARG C 1 40  ? -26.958 10.374  43.944  1    136.88 ? 36  ARG C NH2 1 
ATOM   4842 N  N   . LEU C 1 41  ? -25.132 3.457   41.31   1    59.15  ? 37  LEU C N   1 
ATOM   4843 C  CA  . LEU C 1 41  ? -25.509 2.134   41.754  1    61.86  ? 37  LEU C CA  1 
ATOM   4844 C  C   . LEU C 1 41  ? -25.176 1.999   43.247  1    69.46  ? 37  LEU C C   1 
ATOM   4845 O  O   . LEU C 1 41  ? -24.243 2.627   43.785  1    66.67  ? 37  LEU C O   1 
ATOM   4846 C  CB  . LEU C 1 41  ? -24.817 1.076   40.896  1    57.2   ? 37  LEU C CB  1 
ATOM   4847 C  CG  . LEU C 1 41  ? -25.103 1.124   39.391  1    56.47  ? 37  LEU C CG  1 
ATOM   4848 C  CD1 . LEU C 1 41  ? -24.483 -0.052  38.655  1    52.73  ? 37  LEU C CD1 1 
ATOM   4849 C  CD2 . LEU C 1 41  ? -26.59  1.192   39.102  1    54.84  ? 37  LEU C CD2 1 
ATOM   4850 N  N   . ASP C 1 42  ? -25.983 1.166   43.913  1    67.78  ? 38  ASP C N   1 
ATOM   4851 C  CA  . ASP C 1 42  ? -25.775 0.811   45.309  1    66.6   ? 38  ASP C CA  1 
ATOM   4852 C  C   . ASP C 1 42  ? -25.086 -0.553  45.369  1    58.09  ? 38  ASP C C   1 
ATOM   4853 O  O   . ASP C 1 42  ? -25.736 -1.541  45.684  1    58.85  ? 38  ASP C O   1 
ATOM   4854 C  CB  . ASP C 1 42  ? -27.116 0.908   46.035  1    69.46  ? 38  ASP C CB  1 
ATOM   4855 C  CG  . ASP C 1 42  ? -27.637 2.327   46.22   1    70.58  ? 38  ASP C CG  1 
ATOM   4856 O  OD1 . ASP C 1 42  ? -26.791 3.18    46.546  1    74.27  ? 38  ASP C OD1 1 
ATOM   4857 O  OD2 . ASP C 1 42  ? -28.864 2.574   46.036  1    72.56  ? 38  ASP C OD2 1 
ATOM   4858 N  N   . THR C 1 43  ? -23.79  -0.615  45.05   1    53.62  ? 39  THR C N   1 
ATOM   4859 C  CA  . THR C 1 43  ? -23.14  -1.903  44.829  1    53.78  ? 39  THR C CA  1 
ATOM   4860 C  C   . THR C 1 43  ? -22.988 -2.773  46.081  1    55.66  ? 39  THR C C   1 
ATOM   4861 O  O   . THR C 1 43  ? -22.668 -3.947  45.947  1    56.74  ? 39  THR C O   1 
ATOM   4862 C  CB  . THR C 1 43  ? -21.805 -1.753  44.104  1    54.39  ? 39  THR C CB  1 
ATOM   4863 O  OG1 . THR C 1 43  ? -21.009 -0.759  44.74   1    58.92  ? 39  THR C OG1 1 
ATOM   4864 C  CG2 . THR C 1 43  ? -22.014 -1.314  42.664  1    50.85  ? 39  THR C CG2 1 
ATOM   4865 N  N   . GLU C 1 44  ? -23.178 -2.228  47.292  1    56.65  ? 40  GLU C N   1 
ATOM   4866 C  CA  . GLU C 1 44  ? -23.008 -3.039  48.491  1    60.23  ? 40  GLU C CA  1 
ATOM   4867 C  C   . GLU C 1 44  ? -24.341 -3.231  49.229  1    61.25  ? 40  GLU C C   1 
ATOM   4868 O  O   . GLU C 1 44  ? -24.351 -3.837  50.296  1    63.61  ? 40  GLU C O   1 
ATOM   4869 C  CB  . GLU C 1 44  ? -21.922 -2.483  49.406  1    61.53  ? 40  GLU C CB  1 
ATOM   4870 C  CG  . GLU C 1 44  ? -20.507 -2.53   48.836  1    62.57  ? 40  GLU C CG  1 
ATOM   4871 C  CD  . GLU C 1 44  ? -20.196 -1.532  47.718  1    63.03  ? 40  GLU C CD  1 
ATOM   4872 O  OE1 . GLU C 1 44  ? -19.604 -2.004  46.706  1    66.58  ? 40  GLU C OE1 1 
ATOM   4873 O  OE2 . GLU C 1 44  ? -20.523 -0.312  47.793  1    60.75  ? 40  GLU C OE2 1 
ATOM   4874 N  N   . THR C 1 45  ? -25.457 -2.754  48.642  1    58.48  ? 41  THR C N   1 
ATOM   4875 C  CA  . THR C 1 45  ? -26.724 -2.639  49.355  1    60.05  ? 41  THR C CA  1 
ATOM   4876 C  C   . THR C 1 45  ? -27.916 -3.011  48.473  1    57.68  ? 41  THR C C   1 
ATOM   4877 O  O   . THR C 1 45  ? -28.42  -4.121  48.587  1    61.85  ? 41  THR C O   1 
ATOM   4878 C  CB  . THR C 1 45  ? -26.903 -1.253  49.985  1    59.97  ? 41  THR C CB  1 
ATOM   4879 O  OG1 . THR C 1 45  ? -26.74  -0.296  48.932  1    57.47  ? 41  THR C OG1 1 
ATOM   4880 C  CG2 . THR C 1 45  ? -25.944 -1.017  51.141  1    61.12  ? 41  THR C CG2 1 
ATOM   4881 N  N   . GLU C 1 46  ? -28.379 -2.087  47.641  1    52.83  ? 42  GLU C N   1 
ATOM   4882 C  CA  . GLU C 1 46  ? -29.683 -2.186  47.023  1    53.51  ? 42  GLU C CA  1 
ATOM   4883 C  C   . GLU C 1 46  ? -29.571 -2.49   45.524  1    52.39  ? 42  GLU C C   1 
ATOM   4884 O  O   . GLU C 1 46  ? -30.534 -2.971  44.948  1    52.38  ? 42  GLU C O   1 
ATOM   4885 C  CB  . GLU C 1 46  ? -30.516 -0.941  47.353  1    54.57  ? 42  GLU C CB  1 
ATOM   4886 C  CG  . GLU C 1 46  ? -31.047 -0.945  48.792  1    61.73  ? 42  GLU C CG  1 
ATOM   4887 C  CD  . GLU C 1 46  ? -31.311 -2.317  49.472  1    70.65  ? 42  GLU C CD  1 
ATOM   4888 O  OE1 . GLU C 1 46  ? -32.181 -3.115  48.981  1    69.68  ? 42  GLU C OE1 1 
ATOM   4889 O  OE2 . GLU C 1 46  ? -30.656 -2.62   50.529  1    74.54  ? 42  GLU C OE2 1 
ATOM   4890 N  N   . GLY C 1 47  ? -28.413 -2.231  44.893  1    49.84  ? 43  GLY C N   1 
ATOM   4891 C  CA  . GLY C 1 47  ? -28.178 -2.571  43.5    1    45.84  ? 43  GLY C CA  1 
ATOM   4892 C  C   . GLY C 1 47  ? -28.74  -1.492  42.583  1    45.41  ? 43  GLY C C   1 
ATOM   4893 O  O   . GLY C 1 47  ? -28.722 -0.314  42.921  1    50.01  ? 43  GLY C O   1 
ATOM   4894 N  N   . VAL C 1 48  ? -29.283 -1.894  41.435  1    43     ? 44  VAL C N   1 
ATOM   4895 C  CA  . VAL C 1 48  ? -29.753 -0.947  40.439  1    42.34  ? 44  VAL C CA  1 
ATOM   4896 C  C   . VAL C 1 48  ? -31.155 -0.501  40.845  1    43.82  ? 44  VAL C C   1 
ATOM   4897 O  O   . VAL C 1 48  ? -32.032 -1.338  41.038  1    44.31  ? 44  VAL C O   1 
ATOM   4898 C  CB  . VAL C 1 48  ? -29.793 -1.611  39.041  1    39.61  ? 44  VAL C CB  1 
ATOM   4899 C  CG1 . VAL C 1 48  ? -30.194 -0.633  37.945  1    35.84  ? 44  VAL C CG1 1 
ATOM   4900 C  CG2 . VAL C 1 48  ? -28.498 -2.36   38.731  1    40.11  ? 44  VAL C CG2 1 
ATOM   4901 N  N   . PRO C 1 49  ? -31.421 0.816   40.978  1    43.59  ? 45  PRO C N   1 
ATOM   4902 C  CA  . PRO C 1 49  ? -32.734 1.283   41.44   1    42.75  ? 45  PRO C CA  1 
ATOM   4903 C  C   . PRO C 1 49  ? -33.824 0.852   40.462  1    44.82  ? 45  PRO C C   1 
ATOM   4904 O  O   . PRO C 1 49  ? -33.613 0.874   39.225  1    47.52  ? 45  PRO C O   1 
ATOM   4905 C  CB  . PRO C 1 49  ? -32.619 2.834   41.454  1    41.03  ? 45  PRO C CB  1 
ATOM   4906 C  CG  . PRO C 1 49  ? -31.145 3.125   41.291  1    42     ? 45  PRO C CG  1 
ATOM   4907 C  CD  . PRO C 1 49  ? -30.481 1.909   40.66   1    41.99  ? 45  PRO C CD  1 
ATOM   4908 N  N   . SER C 1 50  ? -35.007 0.545   41.023  1    43.94  ? 46  SER C N   1 
ATOM   4909 C  CA  . SER C 1 50  ? -36.164 0.156   40.228  1    46.05  ? 46  SER C CA  1 
ATOM   4910 C  C   . SER C 1 50  ? -36.563 1.253   39.243  1    46.82  ? 46  SER C C   1 
ATOM   4911 O  O   . SER C 1 50  ? -36.983 0.953   38.132  1    48.72  ? 46  SER C O   1 
ATOM   4912 C  CB  . SER C 1 50  ? -37.303 -0.211  41.102  1    50.64  ? 46  SER C CB  1 
ATOM   4913 O  OG  . SER C 1 50  ? -37.489 0.779   42.1    1    55.94  ? 46  SER C OG  1 
ATOM   4914 N  N   . THR C 1 51  ? -36.398 2.522   39.638  1    44.8   ? 47  THR C N   1 
ATOM   4915 C  CA  . THR C 1 51  ? -36.733 3.621   38.75   1    46.52  ? 47  THR C CA  1 
ATOM   4916 C  C   . THR C 1 51  ? -35.895 3.541   37.467  1    45.1   ? 47  THR C C   1 
ATOM   4917 O  O   . THR C 1 51  ? -36.416 3.772   36.374  1    46.93  ? 47  THR C O   1 
ATOM   4918 C  CB  . THR C 1 51  ? -36.624 4.965   39.474  1    47.54  ? 47  THR C CB  1 
ATOM   4919 O  OG1 . THR C 1 51  ? -36.876 5.981   38.508  1    52.63  ? 47  THR C OG1 1 
ATOM   4920 C  CG2 . THR C 1 51  ? -35.234 5.22    40.008  1    46.99  ? 47  THR C CG2 1 
ATOM   4921 N  N   . ALA C 1 52  ? -34.626 3.134   37.587  1    41.22  ? 48  ALA C N   1 
ATOM   4922 C  CA  . ALA C 1 52  ? -33.759 3.145   36.431  1    39.53  ? 48  ALA C CA  1 
ATOM   4923 C  C   . ALA C 1 52  ? -34.075 1.946   35.522  1    41.21  ? 48  ALA C C   1 
ATOM   4924 O  O   . ALA C 1 52  ? -34.073 2.056   34.285  1    38.92  ? 48  ALA C O   1 
ATOM   4925 C  CB  . ALA C 1 52  ? -32.322 3.192   36.89   1    38.22  ? 48  ALA C CB  1 
ATOM   4926 N  N   . ILE C 1 53  ? -34.368 0.794   36.141  1    40.88  ? 49  ILE C N   1 
ATOM   4927 C  CA  . ILE C 1 53  ? -34.745 -0.387  35.388  1    41.47  ? 49  ILE C CA  1 
ATOM   4928 C  C   . ILE C 1 53  ? -35.979 -0.093  34.545  1    42.45  ? 49  ILE C C   1 
ATOM   4929 O  O   . ILE C 1 53  ? -36.021 -0.475  33.37   1    43.43  ? 49  ILE C O   1 
ATOM   4930 C  CB  . ILE C 1 53  ? -34.973 -1.562  36.346  1    43.65  ? 49  ILE C CB  1 
ATOM   4931 C  CG1 . ILE C 1 53  ? -33.68  -2.026  36.922  1    42.35  ? 49  ILE C CG1 1 
ATOM   4932 C  CG2 . ILE C 1 53  ? -35.731 -2.708  35.672  1    43.07  ? 49  ILE C CG2 1 
ATOM   4933 C  CD1 . ILE C 1 53  ? -33.923 -2.877  38.151  1    48.61  ? 49  ILE C CD1 1 
ATOM   4934 N  N   . ARG C 1 54  ? -36.957 0.584   35.151  1    40.82  ? 50  ARG C N   1 
ATOM   4935 C  CA  . ARG C 1 54  ? -38.185 0.912   34.446  1    42.63  ? 50  ARG C CA  1 
ATOM   4936 C  C   . ARG C 1 54  ? -37.907 1.95    33.372  1    44.2   ? 50  ARG C C   1 
ATOM   4937 O  O   . ARG C 1 54  ? -38.375 1.78    32.249  1    45.62  ? 50  ARG C O   1 
ATOM   4938 C  CB  . ARG C 1 54  ? -39.271 1.443   35.385  1    43.23  ? 50  ARG C CB  1 
ATOM   4939 C  CG  . ARG C 1 54  ? -39.909 0.36    36.239  1    43.33  ? 50  ARG C CG  1 
ATOM   4940 C  CD  . ARG C 1 54  ? -40.937 0.96    37.177  1    44.09  ? 50  ARG C CD  1 
ATOM   4941 N  NE  . ARG C 1 54  ? -41.526 -0.058  38.043  1    44.31  ? 50  ARG C NE  1 
ATOM   4942 C  CZ  . ARG C 1 54  ? -42.361 0.26    39.024  1    47.44  ? 50  ARG C CZ  1 
ATOM   4943 N  NH1 . ARG C 1 54  ? -42.592 1.536   39.316  1    44.68  ? 50  ARG C NH1 1 
ATOM   4944 N  NH2 . ARG C 1 54  ? -42.958 -0.707  39.707  1    47.79  ? 50  ARG C NH2 1 
ATOM   4945 N  N   . GLU C 1 55  ? -37.154 3.008   33.72   1    45.33  ? 51  GLU C N   1 
ATOM   4946 C  CA  . GLU C 1 55  ? -36.885 4.08    32.774  1    44     ? 51  GLU C CA  1 
ATOM   4947 C  C   . GLU C 1 55  ? -36.185 3.517   31.536  1    46.22  ? 51  GLU C C   1 
ATOM   4948 O  O   . GLU C 1 55  ? -36.616 3.737   30.413  1    45.07  ? 51  GLU C O   1 
ATOM   4949 C  CB  . GLU C 1 55  ? -36.091 5.215   33.413  1    43.39  ? 51  GLU C CB  1 
ATOM   4950 C  CG  . GLU C 1 55  ? -35.586 6.233   32.397  1    46.06  ? 51  GLU C CG  1 
ATOM   4951 C  CD  . GLU C 1 55  ? -35.134 7.558   32.968  1    48.37  ? 51  GLU C CD  1 
ATOM   4952 O  OE1 . GLU C 1 55  ? -34.905 7.663   34.177  1    51.48  ? 51  GLU C OE1 1 
ATOM   4953 O  OE2 . GLU C 1 55  ? -35.111 8.524   32.194  1    54.1   ? 51  GLU C OE2 1 
ATOM   4954 N  N   . ILE C 1 56  ? -35.136 2.729   31.75   1    46.07  ? 52  ILE C N   1 
ATOM   4955 C  CA  . ILE C 1 56  ? -34.39  2.17    30.636  1    44.28  ? 52  ILE C CA  1 
ATOM   4956 C  C   . ILE C 1 56  ? -35.241 1.195   29.829  1    43.27  ? 52  ILE C C   1 
ATOM   4957 O  O   . ILE C 1 56  ? -35.279 1.307   28.604  1    44.8   ? 52  ILE C O   1 
ATOM   4958 C  CB  . ILE C 1 56  ? -33.063 1.538   31.09   1    40.48  ? 52  ILE C CB  1 
ATOM   4959 C  CG1 . ILE C 1 56  ? -32.165 2.619   31.668  1    40.23  ? 52  ILE C CG1 1 
ATOM   4960 C  CG2 . ILE C 1 56  ? -32.395 0.79    29.934  1    38.14  ? 52  ILE C CG2 1 
ATOM   4961 C  CD1 . ILE C 1 56  ? -31.166 2.119   32.704  1    43.39  ? 52  ILE C CD1 1 
ATOM   4962 N  N   . SER C 1 57  ? -35.903 0.25    30.5    1    42.99  ? 53  SER C N   1 
ATOM   4963 C  CA  . SER C 1 57  ? -36.612 -0.79   29.77   1    48.94  ? 53  SER C CA  1 
ATOM   4964 C  C   . SER C 1 57  ? -37.742 -0.173  28.945  1    50.82  ? 53  SER C C   1 
ATOM   4965 O  O   . SER C 1 57  ? -37.933 -0.554  27.792  1    54.03  ? 53  SER C O   1 
ATOM   4966 C  CB  . SER C 1 57  ? -37.123 -1.874  30.682  1    53.39  ? 53  SER C CB  1 
ATOM   4967 O  OG  . SER C 1 57  ? -37.807 -1.288  31.787  1    63.64  ? 53  SER C OG  1 
ATOM   4968 N  N   . LEU C 1 58  ? -38.444 0.811   29.522  1    45.06  ? 54  LEU C N   1 
ATOM   4969 C  CA  . LEU C 1 58  ? -39.614 1.371   28.876  1    43.95  ? 54  LEU C CA  1 
ATOM   4970 C  C   . LEU C 1 58  ? -39.194 2.277   27.735  1    47.25  ? 54  LEU C C   1 
ATOM   4971 O  O   . LEU C 1 58  ? -39.824 2.21    26.681  1    48.94  ? 54  LEU C O   1 
ATOM   4972 C  CB  . LEU C 1 58  ? -40.582 2.041   29.846  1    42.11  ? 54  LEU C CB  1 
ATOM   4973 C  CG  . LEU C 1 58  ? -41.117 1.101   30.944  1    43.4   ? 54  LEU C CG  1 
ATOM   4974 C  CD1 . LEU C 1 58  ? -42.062 1.771   31.911  1    40.83  ? 54  LEU C CD1 1 
ATOM   4975 C  CD2 . LEU C 1 58  ? -41.811 -0.084  30.322  1    44.82  ? 54  LEU C CD2 1 
ATOM   4976 N  N   . LEU C 1 59  ? -38.113 3.064   27.924  1    48.45  ? 55  LEU C N   1 
ATOM   4977 C  CA  . LEU C 1 59  ? -37.662 4.008   26.905  1    47.8   ? 55  LEU C CA  1 
ATOM   4978 C  C   . LEU C 1 59  ? -36.958 3.324   25.735  1    50.36  ? 55  LEU C C   1 
ATOM   4979 O  O   . LEU C 1 59  ? -36.962 3.857   24.63   1    55.07  ? 55  LEU C O   1 
ATOM   4980 C  CB  . LEU C 1 59  ? -36.765 5.076   27.51   1    46.78  ? 55  LEU C CB  1 
ATOM   4981 C  CG  . LEU C 1 59  ? -37.444 6.283   28.152  1    44.34  ? 55  LEU C CG  1 
ATOM   4982 C  CD1 . LEU C 1 59  ? -36.349 7.264   28.459  1    42.69  ? 55  LEU C CD1 1 
ATOM   4983 C  CD2 . LEU C 1 59  ? -38.505 6.902   27.248  1    45.92  ? 55  LEU C CD2 1 
ATOM   4984 N  N   . LYS C 1 60  ? -36.347 2.156   25.963  1    51.66  ? 56  LYS C N   1 
ATOM   4985 C  CA  . LYS C 1 60  ? -35.739 1.387   24.881  1    52.34  ? 56  LYS C CA  1 
ATOM   4986 C  C   . LYS C 1 60  ? -36.797 0.929   23.876  1    55.42  ? 56  LYS C C   1 
ATOM   4987 O  O   . LYS C 1 60  ? -36.518 0.804   22.673  1    57.03  ? 56  LYS C O   1 
ATOM   4988 C  CB  . LYS C 1 60  ? -34.99  0.166   25.417  1    50.51  ? 56  LYS C CB  1 
ATOM   4989 C  CG  . LYS C 1 60  ? -33.57  0.452   25.891  1    53.2   ? 56  LYS C CG  1 
ATOM   4990 C  CD  . LYS C 1 60  ? -32.751 -0.811  26.098  1    57.83  ? 56  LYS C CD  1 
ATOM   4991 C  CE  . LYS C 1 60  ? -32.976 -1.672  24.895  1    59.71  ? 56  LYS C CE  1 
ATOM   4992 N  NZ  . LYS C 1 60  ? -32.377 -3.014  24.823  1    67.1   ? 56  LYS C NZ  1 
ATOM   4993 N  N   . GLU C 1 61  ? -38.005 0.677   24.396  1    55.23  ? 57  GLU C N   1 
ATOM   4994 C  CA  . GLU C 1 61  ? -39.123 0.163   23.622  1    54.43  ? 57  GLU C CA  1 
ATOM   4995 C  C   . GLU C 1 61  ? -39.825 1.287   22.871  1    55.07  ? 57  GLU C C   1 
ATOM   4996 O  O   . GLU C 1 61  ? -40.239 1.078   21.729  1    60.26  ? 57  GLU C O   1 
ATOM   4997 C  CB  . GLU C 1 61  ? -40.177 -0.484  24.516  1    57.09  ? 57  GLU C CB  1 
ATOM   4998 C  CG  . GLU C 1 61  ? -39.903 -1.953  24.807  1    59.08  ? 57  GLU C CG  1 
ATOM   4999 C  CD  . GLU C 1 61  ? -41.063 -2.569  25.566  1    64.19  ? 57  GLU C CD  1 
ATOM   5000 O  OE1 . GLU C 1 61  ? -42.167 -1.965  25.512  1    62.6   ? 57  GLU C OE1 1 
ATOM   5001 O  OE2 . GLU C 1 61  ? -40.882 -3.66   26.166  1    70.19  ? 57  GLU C OE2 1 
ATOM   5002 N  N   . LEU C 1 62  ? -39.941 2.456   23.512  1    50.06  ? 58  LEU C N   1 
ATOM   5003 C  CA  . LEU C 1 62  ? -40.745 3.555   23.01   1    51.24  ? 58  LEU C CA  1 
ATOM   5004 C  C   . LEU C 1 62  ? -39.924 4.438   22.07   1    52.76  ? 58  LEU C C   1 
ATOM   5005 O  O   . LEU C 1 62  ? -39.153 5.255   22.542  1    57.53  ? 58  LEU C O   1 
ATOM   5006 C  CB  . LEU C 1 62  ? -41.232 4.363   24.216  1    50.24  ? 58  LEU C CB  1 
ATOM   5007 C  CG  . LEU C 1 62  ? -42.213 3.662   25.166  1    52.52  ? 58  LEU C CG  1 
ATOM   5008 C  CD1 . LEU C 1 62  ? -42.306 4.433   26.445  1    49.03  ? 58  LEU C CD1 1 
ATOM   5009 C  CD2 . LEU C 1 62  ? -43.609 3.456   24.6    1    54.48  ? 58  LEU C CD2 1 
ATOM   5010 N  N   . ASN C 1 63  ? -40.122 4.319   20.746  1    55.93  ? 59  ASN C N   1 
ATOM   5011 C  CA  . ASN C 1 63  ? -39.483 5.229   19.804  1    56.25  ? 59  ASN C CA  1 
ATOM   5012 C  C   . ASN C 1 63  ? -40.54  6.042   19.08   1    54.06  ? 59  ASN C C   1 
ATOM   5013 O  O   . ASN C 1 63  ? -41.296 5.503   18.28   1    56.19  ? 59  ASN C O   1 
ATOM   5014 C  CB  . ASN C 1 63  ? -38.489 4.544   18.879  1    64.62  ? 59  ASN C CB  1 
ATOM   5015 C  CG  . ASN C 1 63  ? -37.243 4.153   19.654  1    86.8   ? 59  ASN C CG  1 
ATOM   5016 O  OD1 . ASN C 1 63  ? -37.088 2.984   20.037  1    94.89  ? 59  ASN C OD1 1 
ATOM   5017 N  ND2 . ASN C 1 63  ? -36.382 5.114   19.979  1    76.32  ? 59  ASN C ND2 1 
ATOM   5018 N  N   . HIS C 1 64  ? -40.6   7.336   19.407  1    51.7   ? 60  HIS C N   1 
ATOM   5019 C  CA  . HIS C 1 64  ? -41.589 8.232   18.832  1    53.99  ? 60  HIS C CA  1 
ATOM   5020 C  C   . HIS C 1 64  ? -41.025 9.649   18.82   1    53.14  ? 60  HIS C C   1 
ATOM   5021 O  O   . HIS C 1 64  ? -40.308 10.04   19.726  1    58.77  ? 60  HIS C O   1 
ATOM   5022 C  CB  . HIS C 1 64  ? -42.92  8.134   19.589  1    53.34  ? 60  HIS C CB  1 
ATOM   5023 C  CG  . HIS C 1 64  ? -44.024 8.924   18.99   1    57.98  ? 60  HIS C CG  1 
ATOM   5024 N  ND1 . HIS C 1 64  ? -44.081 10.301  19.105  1    60.19  ? 60  HIS C ND1 1 
ATOM   5025 C  CD2 . HIS C 1 64  ? -45.12  8.547   18.291  1    57.39  ? 60  HIS C CD2 1 
ATOM   5026 C  CE1 . HIS C 1 64  ? -45.179 10.734  18.474  1    60.54  ? 60  HIS C CE1 1 
ATOM   5027 N  NE2 . HIS C 1 64  ? -45.825 9.687   17.983  1    55.7   ? 60  HIS C NE2 1 
ATOM   5028 N  N   . PRO C 1 65  ? -41.313 10.461  17.793  1    54.93  ? 61  PRO C N   1 
ATOM   5029 C  CA  . PRO C 1 65  ? -40.752 11.812  17.738  1    53.49  ? 61  PRO C CA  1 
ATOM   5030 C  C   . PRO C 1 65  ? -41.123 12.758  18.874  1    51.13  ? 61  PRO C C   1 
ATOM   5031 O  O   . PRO C 1 65  ? -40.514 13.82   18.971  1    53.8   ? 61  PRO C O   1 
ATOM   5032 C  CB  . PRO C 1 65  ? -41.207 12.382  16.366  1    53.18  ? 61  PRO C CB  1 
ATOM   5033 C  CG  . PRO C 1 65  ? -42.35  11.45   15.935  1    54.46  ? 61  PRO C CG  1 
ATOM   5034 C  CD  . PRO C 1 65  ? -42.113 10.101  16.601  1    53.16  ? 61  PRO C CD  1 
ATOM   5035 N  N   . ASN C 1 66  ? -42.115 12.39   19.698  1    47.2   ? 62  ASN C N   1 
ATOM   5036 C  CA  . ASN C 1 66  ? -42.526 13.245  20.808  1    49.79  ? 62  ASN C CA  1 
ATOM   5037 C  C   . ASN C 1 66  ? -42.259 12.58   22.169  1    54.97  ? 62  ASN C C   1 
ATOM   5038 O  O   . ASN C 1 66  ? -42.86  12.999  23.177  1    52.17  ? 62  ASN C O   1 
ATOM   5039 C  CB  . ASN C 1 66  ? -43.987 13.674  20.7    1    47.64  ? 62  ASN C CB  1 
ATOM   5040 C  CG  . ASN C 1 66  ? -44.241 14.442  19.425  1    51.98  ? 62  ASN C CG  1 
ATOM   5041 O  OD1 . ASN C 1 66  ? -45.062 14.027  18.59   1    58.21  ? 62  ASN C OD1 1 
ATOM   5042 N  ND2 . ASN C 1 66  ? -43.545 15.557  19.245  1    48     ? 62  ASN C ND2 1 
ATOM   5043 N  N   . ILE C 1 67  ? -41.389 11.542  22.179  1    47.98  ? 63  ILE C N   1 
ATOM   5044 C  CA  . ILE C 1 67  ? -40.821 10.978  23.391  1    45.21  ? 63  ILE C CA  1 
ATOM   5045 C  C   . ILE C 1 67  ? -39.305 11.151  23.34   1    48.86  ? 63  ILE C C   1 
ATOM   5046 O  O   . ILE C 1 67  ? -38.686 10.962  22.282  1    51.21  ? 63  ILE C O   1 
ATOM   5047 C  CB  . ILE C 1 67  ? -41.226 9.502   23.496  1    43.78  ? 63  ILE C CB  1 
ATOM   5048 C  CG1 . ILE C 1 67  ? -42.746 9.373   23.6    1    41.61  ? 63  ILE C CG1 1 
ATOM   5049 C  CG2 . ILE C 1 67  ? -40.504 8.776   24.63   1    40.36  ? 63  ILE C CG2 1 
ATOM   5050 C  CD1 . ILE C 1 67  ? -43.227 7.949   23.509  1    38.15  ? 63  ILE C CD1 1 
ATOM   5051 N  N   . VAL C 1 68  ? -38.71  11.536  24.476  1    45.75  ? 64  VAL C N   1 
ATOM   5052 C  CA  . VAL C 1 68  ? -37.278 11.806  24.509  1    46.65  ? 64  VAL C CA  1 
ATOM   5053 C  C   . VAL C 1 68  ? -36.531 10.528  24.108  1    46.36  ? 64  VAL C C   1 
ATOM   5054 O  O   . VAL C 1 68  ? -36.901 9.431   24.516  1    44.1   ? 64  VAL C O   1 
ATOM   5055 C  CB  . VAL C 1 68  ? -36.804 12.37   25.863  1    42.03  ? 64  VAL C CB  1 
ATOM   5056 C  CG1 . VAL C 1 68  ? -36.955 11.348  26.979  1    38.98  ? 64  VAL C CG1 1 
ATOM   5057 C  CG2 . VAL C 1 68  ? -35.376 12.89   25.799  1    40.64  ? 64  VAL C CG2 1 
ATOM   5058 N  N   . LYS C 1 69  ? -35.475 10.695  23.31   1    43.65  ? 65  LYS C N   1 
ATOM   5059 C  CA  . LYS C 1 69  ? -34.765 9.569   22.734  1    48.22  ? 65  LYS C CA  1 
ATOM   5060 C  C   . LYS C 1 69  ? -33.647 9.144   23.688  1    44.98  ? 65  LYS C C   1 
ATOM   5061 O  O   . LYS C 1 69  ? -32.799 9.948   24.075  1    45.06  ? 65  LYS C O   1 
ATOM   5062 C  CB  . LYS C 1 69  ? -34.327 9.935   21.309  1    49.22  ? 65  LYS C CB  1 
ATOM   5063 C  CG  . LYS C 1 69  ? -33.55  8.884   20.562  1    59.56  ? 65  LYS C CG  1 
ATOM   5064 C  CD  . LYS C 1 69  ? -34.217 7.544   20.269  1    70.38  ? 65  LYS C CD  1 
ATOM   5065 C  CE  . LYS C 1 69  ? -33.427 6.619   19.377  1    75.34  ? 65  LYS C CE  1 
ATOM   5066 N  NZ  . LYS C 1 69  ? -34.001 5.27    19.29   1    67.61  ? 65  LYS C NZ  1 
ATOM   5067 N  N   . LEU C 1 70  ? -33.679 7.867   24.075  1    41.89  ? 66  LEU C N   1 
ATOM   5068 C  CA  . LEU C 1 70  ? -32.585 7.273   24.822  1    41.95  ? 66  LEU C CA  1 
ATOM   5069 C  C   . LEU C 1 70  ? -31.612 6.675   23.802  1    44.05  ? 66  LEU C C   1 
ATOM   5070 O  O   . LEU C 1 70  ? -31.969 5.773   23.052  1    44.35  ? 66  LEU C O   1 
ATOM   5071 C  CB  . LEU C 1 70  ? -33.161 6.215   25.765  1    38.94  ? 66  LEU C CB  1 
ATOM   5072 C  CG  . LEU C 1 70  ? -32.153 5.454   26.626  1    37.34  ? 66  LEU C CG  1 
ATOM   5073 C  CD1 . LEU C 1 70  ? -31.467 6.356   27.654  1    34.57  ? 66  LEU C CD1 1 
ATOM   5074 C  CD2 . LEU C 1 70  ? -32.88  4.314   27.277  1    35.8   ? 66  LEU C CD2 1 
ATOM   5075 N  N   . LEU C 1 71  ? -30.414 7.251   23.726  1    42.8   ? 67  LEU C N   1 
ATOM   5076 C  CA  . LEU C 1 71  ? -29.464 6.901   22.681  1    41.2   ? 67  LEU C CA  1 
ATOM   5077 C  C   . LEU C 1 71  ? -28.602 5.7     23.073  1    42.09  ? 67  LEU C C   1 
ATOM   5078 O  O   . LEU C 1 71  ? -28.333 4.856   22.216  1    42.11  ? 67  LEU C O   1 
ATOM   5079 C  CB  . LEU C 1 71  ? -28.623 8.138   22.383  1    40.61  ? 67  LEU C CB  1 
ATOM   5080 C  CG  . LEU C 1 71  ? -29.422 9.346   21.891  1    39.85  ? 67  LEU C CG  1 
ATOM   5081 C  CD1 . LEU C 1 71  ? -28.543 10.561  21.889  1    37.59  ? 67  LEU C CD1 1 
ATOM   5082 C  CD2 . LEU C 1 71  ? -29.919 9.049   20.464  1    37.95  ? 67  LEU C CD2 1 
ATOM   5083 N  N   . ASP C 1 72  ? -28.222 5.588   24.361  1    41.13  ? 68  ASP C N   1 
ATOM   5084 C  CA  . ASP C 1 72  ? -27.289 4.555   24.777  1    40.51  ? 68  ASP C CA  1 
ATOM   5085 C  C   . ASP C 1 72  ? -27.312 4.384   26.298  1    44.95  ? 68  ASP C C   1 
ATOM   5086 O  O   . ASP C 1 72  ? -27.739 5.287   27.052  1    43.51  ? 68  ASP C O   1 
ATOM   5087 C  CB  . ASP C 1 72  ? -25.889 4.962   24.348  1    41.95  ? 68  ASP C CB  1 
ATOM   5088 C  CG  . ASP C 1 72  ? -24.861 3.851   24.242  1    42.63  ? 68  ASP C CG  1 
ATOM   5089 O  OD1 . ASP C 1 72  ? -25.222 2.683   24.411  1    41.9   ? 68  ASP C OD1 1 
ATOM   5090 O  OD2 . ASP C 1 72  ? -23.696 4.178   23.969  1    48.99  ? 68  ASP C OD2 1 
ATOM   5091 N  N   . VAL C 1 73  ? -26.843 3.22    26.739  1    43.45  ? 69  VAL C N   1 
ATOM   5092 C  CA  . VAL C 1 73  ? -26.708 2.945   28.193  1    45.32  ? 69  VAL C CA  1 
ATOM   5093 C  C   . VAL C 1 73  ? -25.286 2.4     28.366  1    47     ? 69  VAL C C   1 
ATOM   5094 O  O   . VAL C 1 73  ? -24.947 1.423   27.687  1    50.62  ? 69  VAL C O   1 
ATOM   5095 C  CB  . VAL C 1 73  ? -27.752 1.967   28.761  1    44.41  ? 69  VAL C CB  1 
ATOM   5096 C  CG1 . VAL C 1 73  ? -27.548 1.725   30.249  1    43.66  ? 69  VAL C CG1 1 
ATOM   5097 C  CG2 . VAL C 1 73  ? -29.176 2.427   28.481  1    46.65  ? 69  VAL C CG2 1 
ATOM   5098 N  N   . ILE C 1 74  ? -24.479 3.06    29.191  1    50.44  ? 70  ILE C N   1 
ATOM   5099 C  CA  . ILE C 1 74  ? -23.089 2.596   29.455  1    55.9   ? 70  ILE C CA  1 
ATOM   5100 C  C   . ILE C 1 74  ? -23.072 1.976   30.854  1    56.5   ? 70  ILE C C   1 
ATOM   5101 O  O   . ILE C 1 74  ? -23.446 2.676   31.805  1    55.13  ? 70  ILE C O   1 
ATOM   5102 C  CB  . ILE C 1 74  ? -22.074 3.737   29.272  1    57.24  ? 70  ILE C CB  1 
ATOM   5103 C  CG1 . ILE C 1 74  ? -21.808 4.004   27.795  1    56.2   ? 70  ILE C CG1 1 
ATOM   5104 C  CG2 . ILE C 1 74  ? -20.778 3.45    30.028  1    60.79  ? 70  ILE C CG2 1 
ATOM   5105 C  CD1 . ILE C 1 74  ? -22.646 5.12    27.204  1    53.29  ? 70  ILE C CD1 1 
ATOM   5106 N  N   . HIS C 1 75  ? -22.675 0.706   30.95   1    62.34  ? 71  HIS C N   1 
ATOM   5107 C  CA  . HIS C 1 75  ? -22.733 -0.021  32.244  1    72.86  ? 71  HIS C CA  1 
ATOM   5108 C  C   . HIS C 1 75  ? -21.344 -0.218  32.849  1    75.45  ? 71  HIS C C   1 
ATOM   5109 O  O   . HIS C 1 75  ? -20.571 -1.024  32.316  1    86.2   ? 71  HIS C O   1 
ATOM   5110 C  CB  . HIS C 1 75  ? -23.332 -1.42   32.073  1    75.14  ? 71  HIS C CB  1 
ATOM   5111 C  CG  . HIS C 1 75  ? -24.543 -1.545  31.22   1    86.58  ? 71  HIS C CG  1 
ATOM   5112 N  ND1 . HIS C 1 75  ? -24.592 -1.188  29.891  1    87.37  ? 71  HIS C ND1 1 
ATOM   5113 C  CD2 . HIS C 1 75  ? -25.743 -2.046  31.513  1    106.92 ? 71  HIS C CD2 1 
ATOM   5114 C  CE1 . HIS C 1 75  ? -25.8   -1.442  29.416  1    104.98 ? 71  HIS C CE1 1 
ATOM   5115 N  NE2 . HIS C 1 75  ? -26.514 -1.967  30.384  1    119.15 ? 71  HIS C NE2 1 
ATOM   5116 N  N   . THR C 1 76  ? -21.043 0.476   33.943  1    71.4   ? 72  THR C N   1 
ATOM   5117 C  CA  . THR C 1 76  ? -19.771 0.23    34.644  1    71.48  ? 72  THR C CA  1 
ATOM   5118 C  C   . THR C 1 76  ? -20.095 -0.57   35.874  1    73.9   ? 72  THR C C   1 
ATOM   5119 O  O   . THR C 1 76  ? -21.286 -0.708  36.194  1    74.56  ? 72  THR C O   1 
ATOM   5120 C  CB  . THR C 1 76  ? -19.076 1.535   35.011  1    71.45  ? 72  THR C CB  1 
ATOM   5121 O  OG1 . THR C 1 76  ? -19.535 1.849   36.32   1    76.7   ? 72  THR C OG1 1 
ATOM   5122 C  CG2 . THR C 1 76  ? -19.401 2.661   34.047  1    77.25  ? 72  THR C CG2 1 
ATOM   5123 N  N   . GLU C 1 77  ? -19.07  -1.07   36.554  1    75     ? 73  GLU C N   1 
ATOM   5124 C  CA  . GLU C 1 77  ? -19.283 -1.867  37.782  1    72.01  ? 73  GLU C CA  1 
ATOM   5125 C  C   . GLU C 1 77  ? -19.917 -0.978  38.846  1    67.8   ? 73  GLU C C   1 
ATOM   5126 O  O   . GLU C 1 77  ? -20.695 -1.506  39.652  1    72.56  ? 73  GLU C O   1 
ATOM   5127 C  CB  . GLU C 1 77  ? -17.942 -2.409  38.266  1    81.26  ? 73  GLU C CB  1 
ATOM   5128 C  CG  . GLU C 1 77  ? -18.059 -3.406  39.414  1    97.11  ? 73  GLU C CG  1 
ATOM   5129 C  CD  . GLU C 1 77  ? -16.715 -3.828  39.975  1    112.96 ? 73  GLU C CD  1 
ATOM   5130 O  OE1 . GLU C 1 77  ? -16.693 -4.468  41.046  1    114.25 ? 73  GLU C OE1 1 
ATOM   5131 O  OE2 . GLU C 1 77  ? -15.69  -3.516  39.338  1    116.63 ? 73  GLU C OE2 1 
ATOM   5132 N  N   . ASN C 1 78  ? -19.629 0.322   38.823  1    65.17  ? 74  ASN C N   1 
ATOM   5133 C  CA  . ASN C 1 78  ? -20.122 1.163   39.911  1    68.15  ? 74  ASN C CA  1 
ATOM   5134 C  C   . ASN C 1 78  ? -21.166 2.176   39.46   1    69.98  ? 74  ASN C C   1 
ATOM   5135 O  O   . ASN C 1 78  ? -21.936 2.64    40.299  1    69.61  ? 74  ASN C O   1 
ATOM   5136 C  CB  . ASN C 1 78  ? -19.034 1.834   40.752  1    70.05  ? 74  ASN C CB  1 
ATOM   5137 C  CG  . ASN C 1 78  ? -18.001 0.865   41.295  1    78.48  ? 74  ASN C CG  1 
ATOM   5138 O  OD1 . ASN C 1 78  ? -16.816 0.998   40.981  1    85.11  ? 74  ASN C OD1 1 
ATOM   5139 N  ND2 . ASN C 1 78  ? -18.384 -0.135  42.073  1    77.32  ? 74  ASN C ND2 1 
ATOM   5140 N  N   . LYS C 1 79  ? -21.201 2.532   38.164  1    72.36  ? 75  LYS C N   1 
ATOM   5141 C  CA  . LYS C 1 79  ? -22.155 3.538   37.703  1    66.73  ? 75  LYS C CA  1 
ATOM   5142 C  C   . LYS C 1 79  ? -22.777 3.141   36.374  1    60.43  ? 75  LYS C C   1 
ATOM   5143 O  O   . LYS C 1 79  ? -22.275 2.284   35.645  1    63.7   ? 75  LYS C O   1 
ATOM   5144 C  CB  . LYS C 1 79  ? -21.557 4.952   37.707  1    69.56  ? 75  LYS C CB  1 
ATOM   5145 C  CG  . LYS C 1 79  ? -20.075 5.012   37.393  1    75.61  ? 75  LYS C CG  1 
ATOM   5146 C  CD  . LYS C 1 79  ? -19.308 6.067   38.186  1    83.37  ? 75  LYS C CD  1 
ATOM   5147 C  CE  . LYS C 1 79  ? -17.836 6.026   37.87   1    81.94  ? 75  LYS C CE  1 
ATOM   5148 N  NZ  . LYS C 1 79  ? -17.12  7.024   38.685  1    84.91  ? 75  LYS C NZ  1 
ATOM   5149 N  N   . LEU C 1 80  ? -23.883 3.818   36.084  1    55.66  ? 76  LEU C N   1 
ATOM   5150 C  CA  . LEU C 1 80  ? -24.686 3.611   34.895  1    49.82  ? 76  LEU C CA  1 
ATOM   5151 C  C   . LEU C 1 80  ? -24.911 4.984   34.27   1    51.11  ? 76  LEU C C   1 
ATOM   5152 O  O   . LEU C 1 80  ? -25.379 5.897   34.943  1    53.45  ? 76  LEU C O   1 
ATOM   5153 C  CB  . LEU C 1 80  ? -25.99  3.023   35.43   1    49.17  ? 76  LEU C CB  1 
ATOM   5154 C  CG  . LEU C 1 80  ? -26.919 2.287   34.461  1    48.87  ? 76  LEU C CG  1 
ATOM   5155 C  CD1 . LEU C 1 80  ? -26.161 1.175   33.733  1    53.06  ? 76  LEU C CD1 1 
ATOM   5156 C  CD2 . LEU C 1 80  ? -28.051 1.684   35.286  1    47.19  ? 76  LEU C CD2 1 
ATOM   5157 N  N   . TYR C 1 81  ? -24.529 5.144   33.001  1    51.4   ? 77  TYR C N   1 
ATOM   5158 C  CA  . TYR C 1 81  ? -24.74  6.395   32.281  1    52.23  ? 77  TYR C CA  1 
ATOM   5159 C  C   . TYR C 1 81  ? -25.812 6.181   31.206  1    49.18  ? 77  TYR C C   1 
ATOM   5160 O  O   . TYR C 1 81  ? -25.718 5.279   30.387  1    50.46  ? 77  TYR C O   1 
ATOM   5161 C  CB  . TYR C 1 81  ? -23.433 6.894   31.653  1    51.91  ? 77  TYR C CB  1 
ATOM   5162 C  CG  . TYR C 1 81  ? -22.283 7.116   32.62   1    54.65  ? 77  TYR C CG  1 
ATOM   5163 C  CD1 . TYR C 1 81  ? -22.196 8.286   33.354  1    55.65  ? 77  TYR C CD1 1 
ATOM   5164 C  CD2 . TYR C 1 81  ? -21.285 6.163   32.794  1    58.06  ? 77  TYR C CD2 1 
ATOM   5165 C  CE1 . TYR C 1 81  ? -21.161 8.51    34.238  1    55.79  ? 77  TYR C CE1 1 
ATOM   5166 C  CE2 . TYR C 1 81  ? -20.236 6.384   33.671  1    62.96  ? 77  TYR C CE2 1 
ATOM   5167 C  CZ  . TYR C 1 81  ? -20.174 7.56    34.399  1    64.79  ? 77  TYR C CZ  1 
ATOM   5168 O  OH  . TYR C 1 81  ? -19.136 7.785   35.281  1    75.71  ? 77  TYR C OH  1 
ATOM   5169 N  N   . LEU C 1 82  ? -26.857 7       31.244  1    47.97  ? 78  LEU C N   1 
ATOM   5170 C  CA  . LEU C 1 82  ? -27.828 7.051   30.172  1    44.04  ? 78  LEU C CA  1 
ATOM   5171 C  C   . LEU C 1 82  ? -27.464 8.247   29.296  1    44.6   ? 78  LEU C C   1 
ATOM   5172 O  O   . LEU C 1 82  ? -27.247 9.339   29.814  1    43.93  ? 78  LEU C O   1 
ATOM   5173 C  CB  . LEU C 1 82  ? -29.252 7.185   30.706  1    48.17  ? 78  LEU C CB  1 
ATOM   5174 C  CG  . LEU C 1 82  ? -29.706 6.282   31.87   1    52.68  ? 78  LEU C CG  1 
ATOM   5175 C  CD1 . LEU C 1 82  ? -31.212 6.147   31.878  1    45.43  ? 78  LEU C CD1 1 
ATOM   5176 C  CD2 . LEU C 1 82  ? -29.06  4.907   31.892  1    62.6   ? 78  LEU C CD2 1 
ATOM   5177 N  N   . VAL C 1 83  ? -27.33  7.992   27.986  1    42.06  ? 79  VAL C N   1 
ATOM   5178 C  CA  . VAL C 1 83  ? -27.154 9.007   26.966  1    39.22  ? 79  VAL C CA  1 
ATOM   5179 C  C   . VAL C 1 83  ? -28.516 9.312   26.347  1    39.84  ? 79  VAL C C   1 
ATOM   5180 O  O   . VAL C 1 83  ? -29.153 8.432   25.748  1    38.74  ? 79  VAL C O   1 
ATOM   5181 C  CB  . VAL C 1 83  ? -26.173 8.542   25.874  1    38.18  ? 79  VAL C CB  1 
ATOM   5182 C  CG1 . VAL C 1 83  ? -25.797 9.679   24.933  1    37.04  ? 79  VAL C CG1 1 
ATOM   5183 C  CG2 . VAL C 1 83  ? -24.922 7.934   26.471  1    37.5   ? 79  VAL C CG2 1 
ATOM   5184 N  N   . PHE C 1 84  ? -28.955 10.569  26.521  1    40.55  ? 80  PHE C N   1 
ATOM   5185 C  CA  . PHE C 1 84  ? -30.2   11.082  25.952  1    41.09  ? 80  PHE C CA  1 
ATOM   5186 C  C   . PHE C 1 84  ? -29.888 12.117  24.877  1    41.97  ? 80  PHE C C   1 
ATOM   5187 O  O   . PHE C 1 84  ? -28.79  12.687  24.865  1    43.37  ? 80  PHE C O   1 
ATOM   5188 C  CB  . PHE C 1 84  ? -31.035 11.816  27.007  1    40.45  ? 80  PHE C CB  1 
ATOM   5189 C  CG  . PHE C 1 84  ? -31.729 10.891  27.992  1    42.31  ? 80  PHE C CG  1 
ATOM   5190 C  CD1 . PHE C 1 84  ? -31.089 10.512  29.173  1    42.62  ? 80  PHE C CD1 1 
ATOM   5191 C  CD2 . PHE C 1 84  ? -33.003 10.379  27.707  1    42.58  ? 80  PHE C CD2 1 
ATOM   5192 C  CE1 . PHE C 1 84  ? -31.714 9.677   30.073  1    40.67  ? 80  PHE C CE1 1 
ATOM   5193 C  CE2 . PHE C 1 84  ? -33.613 9.519   28.589  1    43.88  ? 80  PHE C CE2 1 
ATOM   5194 C  CZ  . PHE C 1 84  ? -32.952 9.178   29.782  1    45.93  ? 80  PHE C CZ  1 
ATOM   5195 N  N   . GLU C 1 85  ? -30.845 12.351  23.973  1    40.74  ? 81  GLU C N   1 
ATOM   5196 C  CA  . GLU C 1 85  ? -30.667 13.451  23.039  1    41.88  ? 81  GLU C CA  1 
ATOM   5197 C  C   . GLU C 1 85  ? -30.779 14.726  23.863  1    44.87  ? 81  GLU C C   1 
ATOM   5198 O  O   . GLU C 1 85  ? -31.501 14.729  24.855  1    47.54  ? 81  GLU C O   1 
ATOM   5199 C  CB  . GLU C 1 85  ? -31.696 13.444  21.913  1    39.55  ? 81  GLU C CB  1 
ATOM   5200 C  CG  . GLU C 1 85  ? -33.075 13.866  22.379  1    43.24  ? 81  GLU C CG  1 
ATOM   5201 C  CD  . GLU C 1 85  ? -34.206 13.708  21.391  1    45.97  ? 81  GLU C CD  1 
ATOM   5202 O  OE1 . GLU C 1 85  ? -34.107 14.287  20.305  1    51.89  ? 81  GLU C OE1 1 
ATOM   5203 O  OE2 . GLU C 1 85  ? -35.182 13.008  21.715  1    46.34  ? 81  GLU C OE2 1 
ATOM   5204 N  N   . PHE C 1 86  ? -30.075 15.788  23.451  1    43.7   ? 82  PHE C N   1 
ATOM   5205 C  CA  . PHE C 1 86  ? -30.18  17.062  24.129  1    43.83  ? 82  PHE C CA  1 
ATOM   5206 C  C   . PHE C 1 86  ? -31.309 17.874  23.505  1    46.86  ? 82  PHE C C   1 
ATOM   5207 O  O   . PHE C 1 86  ? -31.366 17.979  22.291  1    49.9   ? 82  PHE C O   1 
ATOM   5208 C  CB  . PHE C 1 86  ? -28.881 17.844  23.957  1    44.18  ? 82  PHE C CB  1 
ATOM   5209 C  CG  . PHE C 1 86  ? -28.947 19.231  24.561  1    45.02  ? 82  PHE C CG  1 
ATOM   5210 C  CD1 . PHE C 1 86  ? -28.938 19.401  25.952  1    43.6   ? 82  PHE C CD1 1 
ATOM   5211 C  CD2 . PHE C 1 86  ? -29.06  20.35   23.738  1    45.54  ? 82  PHE C CD2 1 
ATOM   5212 C  CE1 . PHE C 1 86  ? -28.996 20.666  26.508  1    44.72  ? 82  PHE C CE1 1 
ATOM   5213 C  CE2 . PHE C 1 86  ? -29.105 21.628  24.298  1    45.41  ? 82  PHE C CE2 1 
ATOM   5214 C  CZ  . PHE C 1 86  ? -29.096 21.777  25.669  1    47.02  ? 82  PHE C CZ  1 
ATOM   5215 N  N   . LEU C 1 87  ? -32.206 18.429  24.333  1    47.84  ? 83  LEU C N   1 
ATOM   5216 C  CA  . LEU C 1 87  ? -33.155 19.431  23.881  1    48.56  ? 83  LEU C CA  1 
ATOM   5217 C  C   . LEU C 1 87  ? -32.891 20.742  24.612  1    51.77  ? 83  LEU C C   1 
ATOM   5218 O  O   . LEU C 1 87  ? -32.466 20.737  25.765  1    54.1   ? 83  LEU C O   1 
ATOM   5219 C  CB  . LEU C 1 87  ? -34.586 18.939  24.015  1    47.21  ? 83  LEU C CB  1 
ATOM   5220 C  CG  . LEU C 1 87  ? -35.063 18.009  22.885  1    49.46  ? 83  LEU C CG  1 
ATOM   5221 C  CD1 . LEU C 1 87  ? -34.993 16.571  23.329  1    49.31  ? 83  LEU C CD1 1 
ATOM   5222 C  CD2 . LEU C 1 87  ? -36.487 18.324  22.464  1    49.35  ? 83  LEU C CD2 1 
ATOM   5223 N  N   . HIS C 1 88  ? -33.146 21.854  23.914  1    57.78  ? 84  HIS C N   1 
ATOM   5224 C  CA  . HIS C 1 88  ? -32.715 23.189  24.303  1    63.53  ? 84  HIS C CA  1 
ATOM   5225 C  C   . HIS C 1 88  ? -33.169 23.591  25.708  1    59.35  ? 84  HIS C C   1 
ATOM   5226 O  O   . HIS C 1 88  ? -32.361 24.146  26.433  1    60.14  ? 84  HIS C O   1 
ATOM   5227 C  CB  . HIS C 1 88  ? -33.17  24.233  23.283  1    74.6   ? 84  HIS C CB  1 
ATOM   5228 C  CG  . HIS C 1 88  ? -32.825 25.621  23.709  1    91.55  ? 84  HIS C CG  1 
ATOM   5229 N  ND1 . HIS C 1 88  ? -33.738 26.567  24.139  1    92.04  ? 84  HIS C ND1 1 
ATOM   5230 C  CD2 . HIS C 1 88  ? -31.613 26.2    23.789  1    98.63  ? 84  HIS C CD2 1 
ATOM   5231 C  CE1 . HIS C 1 88  ? -33.086 27.681  24.464  1    99.84  ? 84  HIS C CE1 1 
ATOM   5232 N  NE2 . HIS C 1 88  ? -31.799 27.483  24.252  1    102.92 ? 84  HIS C NE2 1 
ATOM   5233 N  N   . GLN C 1 89  ? -34.452 23.374  26.059  1    58.84  ? 85  GLN C N   1 
ATOM   5234 C  CA  . GLN C 1 89  ? -34.966 23.597  27.409  1    57.96  ? 85  GLN C CA  1 
ATOM   5235 C  C   . GLN C 1 89  ? -36.292 22.866  27.639  1    53.24  ? 85  GLN C C   1 
ATOM   5236 O  O   . GLN C 1 89  ? -36.799 22.203  26.735  1    51.06  ? 85  GLN C O   1 
ATOM   5237 C  CB  . GLN C 1 89  ? -35.133 25.069  27.796  1    62.76  ? 85  GLN C CB  1 
ATOM   5238 C  CG  . GLN C 1 89  ? -36.121 25.833  26.917  1    67.89  ? 85  GLN C CG  1 
ATOM   5239 C  CD  . GLN C 1 89  ? -36.209 27.287  27.339  1    71.66  ? 85  GLN C CD  1 
ATOM   5240 O  OE1 . GLN C 1 89  ? -35.612 27.662  28.352  1    71.54  ? 85  GLN C OE1 1 
ATOM   5241 N  NE2 . GLN C 1 89  ? -36.948 28.11   26.602  1    71.86  ? 85  GLN C NE2 1 
ATOM   5242 N  N   . ASP C 1 90  ? -36.817 22.983  28.875  1    49.51  ? 86  ASP C N   1 
ATOM   5243 C  CA  . ASP C 1 90  ? -38.084 22.408  29.286  1    47.9   ? 86  ASP C CA  1 
ATOM   5244 C  C   . ASP C 1 90  ? -39.189 23.471  29.208  1    49.91  ? 86  ASP C C   1 
ATOM   5245 O  O   . ASP C 1 90  ? -38.912 24.661  29.209  1    53.08  ? 86  ASP C O   1 
ATOM   5246 C  CB  . ASP C 1 90  ? -37.999 21.843  30.697  1    46.59  ? 86  ASP C CB  1 
ATOM   5247 C  CG  . ASP C 1 90  ? -37.736 22.865  31.787  1    48.54  ? 86  ASP C CG  1 
ATOM   5248 O  OD1 . ASP C 1 90  ? -38.579 23.762  31.996  1    50     ? 86  ASP C OD1 1 
ATOM   5249 O  OD2 . ASP C 1 90  ? -36.691 22.76   32.427  1    53.67  ? 86  ASP C OD2 1 
ATOM   5250 N  N   . LEU C 1 91  ? -40.447 23.023  29.229  1    46.48  ? 87  LEU C N   1 
ATOM   5251 C  CA  . LEU C 1 91  ? -41.592 23.883  29.027  1    48.35  ? 87  LEU C CA  1 
ATOM   5252 C  C   . LEU C 1 91  ? -41.75  24.865  30.189  1    50.06  ? 87  LEU C C   1 
ATOM   5253 O  O   . LEU C 1 91  ? -42.226 25.977  29.997  1    54.81  ? 87  LEU C O   1 
ATOM   5254 C  CB  . LEU C 1 91  ? -42.822 22.986  28.862  1    48.1   ? 87  LEU C CB  1 
ATOM   5255 C  CG  . LEU C 1 91  ? -44.146 23.714  28.58   1    49.41  ? 87  LEU C CG  1 
ATOM   5256 C  CD1 . LEU C 1 91  ? -44.031 24.441  27.24   1    48.62  ? 87  LEU C CD1 1 
ATOM   5257 C  CD2 . LEU C 1 91  ? -45.334 22.753  28.593  1    46.09  ? 87  LEU C CD2 1 
ATOM   5258 N  N   . LYS C 1 92  ? -41.391 24.457  31.4    1    49.12  ? 88  LYS C N   1 
ATOM   5259 C  CA  . LYS C 1 92  ? -41.504 25.352  32.541  1    53.4   ? 88  LYS C CA  1 
ATOM   5260 C  C   . LYS C 1 92  ? -40.624 26.586  32.319  1    56.82  ? 88  LYS C C   1 
ATOM   5261 O  O   . LYS C 1 92  ? -41.048 27.709  32.584  1    60.28  ? 88  LYS C O   1 
ATOM   5262 C  CB  . LYS C 1 92  ? -41.22  24.612  33.85   1    50.05  ? 88  LYS C CB  1 
ATOM   5263 C  CG  . LYS C 1 92  ? -41.282 25.432  35.101  1    55.22  ? 88  LYS C CG  1 
ATOM   5264 C  CD  . LYS C 1 92  ? -42.638 26.044  35.39   1    68.07  ? 88  LYS C CD  1 
ATOM   5265 C  CE  . LYS C 1 92  ? -42.733 26.719  36.718  1    79.59  ? 88  LYS C CE  1 
ATOM   5266 N  NZ  . LYS C 1 92  ? -43.996 27.465  36.833  1    85.31  ? 88  LYS C NZ  1 
ATOM   5267 N  N   . LYS C 1 93  ? -39.395 26.384  31.833  1    54.87  ? 89  LYS C N   1 
ATOM   5268 C  CA  . LYS C 1 93  ? -38.505 27.518  31.658  1    56.78  ? 89  LYS C CA  1 
ATOM   5269 C  C   . LYS C 1 93  ? -39.019 28.411  30.529  1    54.93  ? 89  LYS C C   1 
ATOM   5270 O  O   . LYS C 1 93  ? -38.851 29.635  30.603  1    55.06  ? 89  LYS C O   1 
ATOM   5271 C  CB  . LYS C 1 93  ? -37.048 27.08   31.477  1    58.84  ? 89  LYS C CB  1 
ATOM   5272 C  CG  . LYS C 1 93  ? -36.402 26.523  32.747  1    65.26  ? 89  LYS C CG  1 
ATOM   5273 C  CD  . LYS C 1 93  ? -34.874 26.586  32.832  1    71.02  ? 89  LYS C CD  1 
ATOM   5274 C  CE  . LYS C 1 93  ? -34.249 25.233  33.036  1    71.87  ? 89  LYS C CE  1 
ATOM   5275 N  NZ  . LYS C 1 93  ? -34.255 24.481  31.765  1    82.14  ? 89  LYS C NZ  1 
ATOM   5276 N  N   . PHE C 1 94  ? -39.657 27.796  29.514  1    50.03  ? 90  PHE C N   1 
ATOM   5277 C  CA  . PHE C 1 94  ? -40.222 28.513  28.376  1    50.84  ? 90  PHE C CA  1 
ATOM   5278 C  C   . PHE C 1 94  ? -41.458 29.326  28.791  1    53.44  ? 90  PHE C C   1 
ATOM   5279 O  O   . PHE C 1 94  ? -41.626 30.476  28.361  1    53.93  ? 90  PHE C O   1 
ATOM   5280 C  CB  . PHE C 1 94  ? -40.552 27.537  27.251  1    51.04  ? 90  PHE C CB  1 
ATOM   5281 C  CG  . PHE C 1 94  ? -41.175 28.204  26.033  1    53.96  ? 90  PHE C CG  1 
ATOM   5282 C  CD1 . PHE C 1 94  ? -40.422 29.033  25.203  1    56.85  ? 90  PHE C CD1 1 
ATOM   5283 C  CD2 . PHE C 1 94  ? -42.522 28.004  25.724  1    54.22  ? 90  PHE C CD2 1 
ATOM   5284 C  CE1 . PHE C 1 94  ? -41.014 29.625  24.087  1    57.98  ? 90  PHE C CE1 1 
ATOM   5285 C  CE2 . PHE C 1 94  ? -43.105 28.589  24.601  1    52.6   ? 90  PHE C CE2 1 
ATOM   5286 C  CZ  . PHE C 1 94  ? -42.354 29.402  23.791  1    55.29  ? 90  PHE C CZ  1 
ATOM   5287 N  N   . MET C 1 95  ? -42.318 28.72   29.624  1    50.86  ? 91  MET C N   1 
ATOM   5288 C  CA  . MET C 1 95  ? -43.445 29.422  30.219  1    52.6   ? 91  MET C CA  1 
ATOM   5289 C  C   . MET C 1 95  ? -42.937 30.664  30.954  1    54.12  ? 91  MET C C   1 
ATOM   5290 O  O   . MET C 1 95  ? -43.41  31.761  30.684  1    59.62  ? 91  MET C O   1 
ATOM   5291 C  CB  . MET C 1 95  ? -44.315 28.506  31.092  1    50.36  ? 91  MET C CB  1 
ATOM   5292 C  CG  . MET C 1 95  ? -45.149 27.513  30.299  1    54.61  ? 91  MET C CG  1 
ATOM   5293 S  SD  . MET C 1 95  ? -46.079 26.204  31.151  1    63.93  ? 91  MET C SD  1 
ATOM   5294 C  CE  . MET C 1 95  ? -45.106 25.911  32.627  1    63.08  ? 91  MET C CE  1 
ATOM   5295 N  N   . ASP C 1 96  ? -41.944 30.517  31.837  1    53.56  ? 92  ASP C N   1 
ATOM   5296 C  CA  . ASP C 1 96  ? -41.455 31.623  32.653  1    55.6   ? 92  ASP C CA  1 
ATOM   5297 C  C   . ASP C 1 96  ? -40.906 32.74   31.771  1    59.37  ? 92  ASP C C   1 
ATOM   5298 O  O   . ASP C 1 96  ? -41.177 33.923  31.994  1    64.11  ? 92  ASP C O   1 
ATOM   5299 C  CB  . ASP C 1 96  ? -40.46  31.167  33.701  1    54.35  ? 92  ASP C CB  1 
ATOM   5300 C  CG  . ASP C 1 96  ? -41.061 30.236  34.742  1    57.07  ? 92  ASP C CG  1 
ATOM   5301 O  OD1 . ASP C 1 96  ? -42.289 30.066  34.74   1    58.61  ? 92  ASP C OD1 1 
ATOM   5302 O  OD2 . ASP C 1 96  ? -40.309 29.667  35.543  1    62.23  ? 92  ASP C OD2 1 
ATOM   5303 N  N   . ALA C 1 97  ? -40.14  32.37   30.747  1    57.88  ? 93  ALA C N   1 
ATOM   5304 C  CA  . ALA C 1 97  ? -39.572 33.381  29.869  1    57.89  ? 93  ALA C CA  1 
ATOM   5305 C  C   . ALA C 1 97  ? -40.701 34.102  29.126  1    57.93  ? 93  ALA C C   1 
ATOM   5306 O  O   . ALA C 1 97  ? -40.52  35.235  28.701  1    58.22  ? 93  ALA C O   1 
ATOM   5307 C  CB  . ALA C 1 97  ? -38.583 32.735  28.916  1    54.65  ? 93  ALA C CB  1 
ATOM   5308 N  N   . SER C 1 98  ? -41.853 33.431  28.977  1    58.24  ? 94  SER C N   1 
ATOM   5309 C  CA  . SER C 1 98  ? -43.006 33.915  28.237  1    60.73  ? 94  SER C CA  1 
ATOM   5310 C  C   . SER C 1 98  ? -44.081 34.457  29.179  1    64.67  ? 94  SER C C   1 
ATOM   5311 O  O   . SER C 1 98  ? -45.188 34.761  28.731  1    68.34  ? 94  SER C O   1 
ATOM   5312 C  CB  . SER C 1 98  ? -43.573 32.817  27.371  1    59.52  ? 94  SER C CB  1 
ATOM   5313 O  OG  . SER C 1 98  ? -42.627 32.442  26.384  1    63.41  ? 94  SER C OG  1 
ATOM   5314 N  N   . ALA C 1 99  ? -43.76  34.616  30.469  1    62.51  ? 95  ALA C N   1 
ATOM   5315 C  CA  . ALA C 1 99  ? -44.754 35.046  31.442  1    64.98  ? 95  ALA C CA  1 
ATOM   5316 C  C   . ALA C 1 99  ? -45.398 36.381  31.039  1    69.01  ? 95  ALA C C   1 
ATOM   5317 O  O   . ALA C 1 99  ? -46.615 36.553  31.163  1    67.69  ? 95  ALA C O   1 
ATOM   5318 C  CB  . ALA C 1 99  ? -44.119 35.126  32.816  1    66.99  ? 95  ALA C CB  1 
ATOM   5319 N  N   . LEU C 1 100 ? -44.565 37.334  30.588  1    68.12  ? 96  LEU C N   1 
ATOM   5320 C  CA  . LEU C 1 100 ? -45.031 38.625  30.126  1    71.06  ? 96  LEU C CA  1 
ATOM   5321 C  C   . LEU C 1 100 ? -45.633 38.511  28.718  1    77.27  ? 96  LEU C C   1 
ATOM   5322 O  O   . LEU C 1 100 ? -46.833 38.743  28.582  1    79.97  ? 96  LEU C O   1 
ATOM   5323 C  CB  . LEU C 1 100 ? -43.918 39.655  30.282  1    69.23  ? 96  LEU C CB  1 
ATOM   5324 C  CG  . LEU C 1 100 ? -43.351 39.724  31.705  1    67.75  ? 96  LEU C CG  1 
ATOM   5325 C  CD1 . LEU C 1 100 ? -42.393 40.853  31.99   1    68.26  ? 96  LEU C CD1 1 
ATOM   5326 C  CD2 . LEU C 1 100 ? -44.468 39.82   32.724  1    67.85  ? 96  LEU C CD2 1 
ATOM   5327 N  N   . THR C 1 101 ? -44.845 38.095  27.697  1    76.6   ? 97  THR C N   1 
ATOM   5328 C  CA  . THR C 1 101 ? -45.274 38.073  26.287  1    74.9   ? 97  THR C CA  1 
ATOM   5329 C  C   . THR C 1 101 ? -46.496 37.185  26.059  1    71.95  ? 97  THR C C   1 
ATOM   5330 O  O   . THR C 1 101 ? -47.3   37.462  25.185  1    73.71  ? 97  THR C O   1 
ATOM   5331 C  CB  . THR C 1 101 ? -44.214 37.618  25.281  1    72.41  ? 97  THR C CB  1 
ATOM   5332 O  OG1 . THR C 1 101 ? -43.976 36.231  25.522  1    70.84  ? 97  THR C OG1 1 
ATOM   5333 C  CG2 . THR C 1 101 ? -42.943 38.436  25.309  1    71.76  ? 97  THR C CG2 1 
ATOM   5334 N  N   . GLY C 1 102 ? -46.604 36.088  26.803  1    70.36  ? 98  GLY C N   1 
ATOM   5335 C  CA  . GLY C 1 102 ? -47.538 35.037  26.439  1    71.87  ? 98  GLY C CA  1 
ATOM   5336 C  C   . GLY C 1 102 ? -46.925 34.088  25.403  1    72.08  ? 98  GLY C C   1 
ATOM   5337 O  O   . GLY C 1 102 ? -45.866 34.358  24.828  1    71.05  ? 98  GLY C O   1 
ATOM   5338 N  N   . ILE C 1 103 ? -47.61  32.956  25.198  1    70.31  ? 99  ILE C N   1 
ATOM   5339 C  CA  . ILE C 1 103 ? -47.242 31.962  24.201  1    70.08  ? 99  ILE C CA  1 
ATOM   5340 C  C   . ILE C 1 103 ? -48.268 32.065  23.075  1    69.35  ? 99  ILE C C   1 
ATOM   5341 O  O   . ILE C 1 103 ? -49.464 31.969  23.33   1    71.59  ? 99  ILE C O   1 
ATOM   5342 C  CB  . ILE C 1 103 ? -47.213 30.55   24.833  1    64.53  ? 99  ILE C CB  1 
ATOM   5343 C  CG1 . ILE C 1 103 ? -46.236 30.49   26.022  1    60.12  ? 99  ILE C CG1 1 
ATOM   5344 C  CG2 . ILE C 1 103 ? -46.929 29.464  23.785  1    60.42  ? 99  ILE C CG2 1 
ATOM   5345 C  CD1 . ILE C 1 103 ? -46.17  29.137  26.715  1    57.04  ? 99  ILE C CD1 1 
ATOM   5346 N  N   . PRO C 1 104 ? -47.857 32.294  21.806  1    69.72  ? 100 PRO C N   1 
ATOM   5347 C  CA  . PRO C 1 104 ? -48.828 32.423  20.72   1    70.14  ? 100 PRO C CA  1 
ATOM   5348 C  C   . PRO C 1 104 ? -49.726 31.188  20.729  1    69.85  ? 100 PRO C C   1 
ATOM   5349 O  O   . PRO C 1 104 ? -49.255 30.086  21.007  1    67.45  ? 100 PRO C O   1 
ATOM   5350 C  CB  . PRO C 1 104 ? -47.892 32.472  19.489  1    71.35  ? 100 PRO C CB  1 
ATOM   5351 C  CG  . PRO C 1 104 ? -46.626 33.119  20.002  1    67.52  ? 100 PRO C CG  1 
ATOM   5352 C  CD  . PRO C 1 104 ? -46.459 32.435  21.351  1    68.81  ? 100 PRO C CD  1 
ATOM   5353 N  N   . LEU C 1 105 ? -51.016 31.38   20.433  1    73.12  ? 101 LEU C N   1 
ATOM   5354 C  CA  . LEU C 1 105 ? -52.008 30.311  20.5    1    77.06  ? 101 LEU C CA  1 
ATOM   5355 C  C   . LEU C 1 105 ? -51.694 29.186  19.501  1    74.78  ? 101 LEU C C   1 
ATOM   5356 O  O   . LEU C 1 105 ? -51.957 28.014  19.77   1    74     ? 101 LEU C O   1 
ATOM   5357 C  CB  . LEU C 1 105 ? -53.413 30.904  20.327  1    83.05  ? 101 LEU C CB  1 
ATOM   5358 C  CG  . LEU C 1 105 ? -54.617 29.987  20.608  1    84.96  ? 101 LEU C CG  1 
ATOM   5359 C  CD1 . LEU C 1 105 ? -54.881 28.952  19.524  1    82.34  ? 101 LEU C CD1 1 
ATOM   5360 C  CD2 . LEU C 1 105 ? -54.509 29.295  21.955  1    82.43  ? 101 LEU C CD2 1 
ATOM   5361 N  N   . PRO C 1 106 ? -51.175 29.481  18.287  1    74.97  ? 102 PRO C N   1 
ATOM   5362 C  CA  . PRO C 1 106 ? -50.696 28.42   17.397  1    72.02  ? 102 PRO C CA  1 
ATOM   5363 C  C   . PRO C 1 106 ? -49.663 27.487  18.015  1    67.87  ? 102 PRO C C   1 
ATOM   5364 O  O   . PRO C 1 106 ? -49.719 26.274  17.793  1    69.12  ? 102 PRO C O   1 
ATOM   5365 C  CB  . PRO C 1 106 ? -50.113 29.201  16.193  1    75.91  ? 102 PRO C CB  1 
ATOM   5366 C  CG  . PRO C 1 106 ? -50.909 30.504  16.18   1    74.57  ? 102 PRO C CG  1 
ATOM   5367 C  CD  . PRO C 1 106 ? -51.116 30.818  17.657  1    74.09  ? 102 PRO C CD  1 
ATOM   5368 N  N   . LEU C 1 107 ? -48.709 28.052  18.769  1    63.15  ? 103 LEU C N   1 
ATOM   5369 C  CA  . LEU C 1 107 ? -47.655 27.249  19.362  1    58.31  ? 103 LEU C CA  1 
ATOM   5370 C  C   . LEU C 1 107 ? -48.244 26.324  20.432  1    56.15  ? 103 LEU C C   1 
ATOM   5371 O  O   . LEU C 1 107 ? -47.874 25.155  20.528  1    55.24  ? 103 LEU C O   1 
ATOM   5372 C  CB  . LEU C 1 107 ? -46.518 28.131  19.876  1    58.2   ? 103 LEU C CB  1 
ATOM   5373 C  CG  . LEU C 1 107 ? -45.279 27.384  20.404  1    58.29  ? 103 LEU C CG  1 
ATOM   5374 C  CD1 . LEU C 1 107 ? -44.63  26.521  19.335  1    57.87  ? 103 LEU C CD1 1 
ATOM   5375 C  CD2 . LEU C 1 107 ? -44.242 28.332  20.959  1    58.57  ? 103 LEU C CD2 1 
ATOM   5376 N  N   . ILE C 1 108 ? -49.201 26.847  21.203  1    56.32  ? 104 ILE C N   1 
ATOM   5377 C  CA  . ILE C 1 108 ? -49.878 26.119  22.262  1    56.34  ? 104 ILE C CA  1 
ATOM   5378 C  C   . ILE C 1 108 ? -50.543 24.872  21.678  1    59.13  ? 104 ILE C C   1 
ATOM   5379 O  O   . ILE C 1 108 ? -50.482 23.774  22.254  1    56.26  ? 104 ILE C O   1 
ATOM   5380 C  CB  . ILE C 1 108 ? -50.886 27.027  22.999  1    55.51  ? 104 ILE C CB  1 
ATOM   5381 C  CG1 . ILE C 1 108 ? -50.19  28.217  23.668  1    55.96  ? 104 ILE C CG1 1 
ATOM   5382 C  CG2 . ILE C 1 108 ? -51.718 26.226  24.002  1    53.2   ? 104 ILE C CG2 1 
ATOM   5383 C  CD1 . ILE C 1 108 ? -51.099 29.182  24.414  1    56.93  ? 104 ILE C CD1 1 
ATOM   5384 N  N   . LYS C 1 109 ? -51.199 25.067  20.534  1    61.54  ? 105 LYS C N   1 
ATOM   5385 C  CA  . LYS C 1 109 ? -51.971 24.003  19.911  1    64.11  ? 105 LYS C CA  1 
ATOM   5386 C  C   . LYS C 1 109 ? -51.024 22.94   19.355  1    61.96  ? 105 LYS C C   1 
ATOM   5387 O  O   . LYS C 1 109 ? -51.246 21.745  19.532  1    64.82  ? 105 LYS C O   1 
ATOM   5388 C  CB  . LYS C 1 109 ? -52.868 24.622  18.839  1    66.98  ? 105 LYS C CB  1 
ATOM   5389 C  CG  . LYS C 1 109 ? -53.744 23.63   18.099  1    68.34  ? 105 LYS C CG  1 
ATOM   5390 C  CD  . LYS C 1 109 ? -54.648 24.334  17.099  1    75.67  ? 105 LYS C CD  1 
ATOM   5391 C  CE  . LYS C 1 109 ? -55.454 25.492  17.67   1    72.2   ? 105 LYS C CE  1 
ATOM   5392 N  NZ  . LYS C 1 109 ? -56.321 26.014  16.622  1    73.75  ? 105 LYS C NZ  1 
ATOM   5393 N  N   . SER C 1 110 ? -49.961 23.396  18.689  1    60.93  ? 106 SER C N   1 
ATOM   5394 C  CA  . SER C 1 110 ? -48.895 22.522  18.24   1    58.64  ? 106 SER C CA  1 
ATOM   5395 C  C   . SER C 1 110 ? -48.361 21.694  19.416  1    54.77  ? 106 SER C C   1 
ATOM   5396 O  O   . SER C 1 110 ? -48.365 20.461  19.366  1    51.95  ? 106 SER C O   1 
ATOM   5397 C  CB  . SER C 1 110 ? -47.81  23.322  17.562  1    60.88  ? 106 SER C CB  1 
ATOM   5398 O  OG  . SER C 1 110 ? -46.719 22.482  17.192  1    63.38  ? 106 SER C OG  1 
ATOM   5399 N  N   . TYR C 1 111 ? -47.936 22.375  20.487  1    52.58  ? 107 TYR C N   1 
ATOM   5400 C  CA  . TYR C 1 111 ? -47.365 21.705  21.644  1    52.88  ? 107 TYR C CA  1 
ATOM   5401 C  C   . TYR C 1 111 ? -48.339 20.7    22.265  1    53.54  ? 107 TYR C C   1 
ATOM   5402 O  O   . TYR C 1 111 ? -47.915 19.6    22.618  1    55.79  ? 107 TYR C O   1 
ATOM   5403 C  CB  . TYR C 1 111 ? -46.879 22.686  22.711  1    53.21  ? 107 TYR C CB  1 
ATOM   5404 C  CG  . TYR C 1 111 ? -45.539 23.363  22.469  1    53.85  ? 107 TYR C CG  1 
ATOM   5405 C  CD1 . TYR C 1 111 ? -44.721 23.014  21.394  1    55.3   ? 107 TYR C CD1 1 
ATOM   5406 C  CD2 . TYR C 1 111 ? -45.082 24.335  23.349  1    52.05  ? 107 TYR C CD2 1 
ATOM   5407 C  CE1 . TYR C 1 111 ? -43.488 23.623  21.211  1    57.59  ? 107 TYR C CE1 1 
ATOM   5408 C  CE2 . TYR C 1 111 ? -43.856 24.952  23.166  1    52.45  ? 107 TYR C CE2 1 
ATOM   5409 C  CZ  . TYR C 1 111 ? -43.057 24.593  22.102  1    55.51  ? 107 TYR C CZ  1 
ATOM   5410 O  OH  . TYR C 1 111 ? -41.853 25.208  21.93   1    61.73  ? 107 TYR C OH  1 
ATOM   5411 N  N   . LEU C 1 112 ? -49.63  21.053  22.378  1    53.65  ? 108 LEU C N   1 
ATOM   5412 C  CA  . LEU C 1 112 ? -50.622 20.16   22.96   1    54.16  ? 108 LEU C CA  1 
ATOM   5413 C  C   . LEU C 1 112 ? -50.825 18.941  22.057  1    55.92  ? 108 LEU C C   1 
ATOM   5414 O  O   . LEU C 1 112 ? -51.054 17.826  22.542  1    55.07  ? 108 LEU C O   1 
ATOM   5415 C  CB  . LEU C 1 112 ? -51.945 20.899  23.198  1    57.04  ? 108 LEU C CB  1 
ATOM   5416 C  CG  . LEU C 1 112 ? -53.091 20.08   23.817  1    58.54  ? 108 LEU C CG  1 
ATOM   5417 C  CD1 . LEU C 1 112 ? -52.687 19.437  25.12   1    60.24  ? 108 LEU C CD1 1 
ATOM   5418 C  CD2 . LEU C 1 112 ? -54.329 20.908  24.077  1    57.39  ? 108 LEU C CD2 1 
ATOM   5419 N  N   . PHE C 1 113 ? -50.776 19.175  20.736  1    57.17  ? 109 PHE C N   1 
ATOM   5420 C  CA  . PHE C 1 113 ? -51.023 18.138  19.744  1    57.99  ? 109 PHE C CA  1 
ATOM   5421 C  C   . PHE C 1 113 ? -49.917 17.085  19.83   1    56.92  ? 109 PHE C C   1 
ATOM   5422 O  O   . PHE C 1 113 ? -50.176 15.887  19.876  1    57.29  ? 109 PHE C O   1 
ATOM   5423 C  CB  . PHE C 1 113 ? -51.092 18.789  18.359  1    59.83  ? 109 PHE C CB  1 
ATOM   5424 C  CG  . PHE C 1 113 ? -51.586 17.891  17.245  1    62.99  ? 109 PHE C CG  1 
ATOM   5425 C  CD1 . PHE C 1 113 ? -52.829 17.265  17.326  1    65.97  ? 109 PHE C CD1 1 
ATOM   5426 C  CD2 . PHE C 1 113 ? -50.802 17.677  16.115  1    67.32  ? 109 PHE C CD2 1 
ATOM   5427 C  CE1 . PHE C 1 113 ? -53.283 16.447  16.291  1    70.92  ? 109 PHE C CE1 1 
ATOM   5428 C  CE2 . PHE C 1 113 ? -51.26  16.852  15.079  1    69.33  ? 109 PHE C CE2 1 
ATOM   5429 C  CZ  . PHE C 1 113 ? -52.493 16.231  15.168  1    68.58  ? 109 PHE C CZ  1 
ATOM   5430 N  N   . GLN C 1 114 ? -48.673 17.561  19.879  1    54.37  ? 110 GLN C N   1 
ATOM   5431 C  CA  . GLN C 1 114 ? -47.514 16.696  19.937  1    53.91  ? 110 GLN C CA  1 
ATOM   5432 C  C   . GLN C 1 114 ? -47.51  15.902  21.235  1    52.58  ? 110 GLN C C   1 
ATOM   5433 O  O   . GLN C 1 114 ? -47.168 14.721  21.226  1    54.3   ? 110 GLN C O   1 
ATOM   5434 C  CB  . GLN C 1 114 ? -46.264 17.559  19.782  1    55.23  ? 110 GLN C CB  1 
ATOM   5435 C  CG  . GLN C 1 114 ? -46.083 18.171  18.394  1    51.73  ? 110 GLN C CG  1 
ATOM   5436 C  CD  . GLN C 1 114 ? -44.795 18.949  18.35   1    54.39  ? 110 GLN C CD  1 
ATOM   5437 O  OE1 . GLN C 1 114 ? -43.702 18.366  18.424  1    56.83  ? 110 GLN C OE1 1 
ATOM   5438 N  NE2 . GLN C 1 114 ? -44.912 20.273  18.305  1    54.55  ? 110 GLN C NE2 1 
ATOM   5439 N  N   . LEU C 1 115 ? -47.847 16.568  22.347  1    52.86  ? 111 LEU C N   1 
ATOM   5440 C  CA  . LEU C 1 115 ? -47.859 15.933  23.662  1    48.8   ? 111 LEU C CA  1 
ATOM   5441 C  C   . LEU C 1 115 ? -48.881 14.792  23.656  1    50.59  ? 111 LEU C C   1 
ATOM   5442 O  O   . LEU C 1 115 ? -48.619 13.735  24.217  1    47.92  ? 111 LEU C O   1 
ATOM   5443 C  CB  . LEU C 1 115 ? -48.211 16.953  24.743  1    45.25  ? 111 LEU C CB  1 
ATOM   5444 C  CG  . LEU C 1 115 ? -47.153 17.986  25.108  1    43.52  ? 111 LEU C CG  1 
ATOM   5445 C  CD1 . LEU C 1 115 ? -47.757 19.006  26.084  1    42.74  ? 111 LEU C CD1 1 
ATOM   5446 C  CD2 . LEU C 1 115 ? -45.991 17.286  25.766  1    44.16  ? 111 LEU C CD2 1 
ATOM   5447 N  N   . LEU C 1 116 ? -50.042 15.016  23.018  1    51.16  ? 112 LEU C N   1 
ATOM   5448 C  CA  . LEU C 1 116 ? -51.064 13.992  22.926  1    54.29  ? 112 LEU C CA  1 
ATOM   5449 C  C   . LEU C 1 116 ? -50.607 12.819  22.055  1    56.55  ? 112 LEU C C   1 
ATOM   5450 O  O   . LEU C 1 116 ? -50.962 11.667  22.341  1    56.91  ? 112 LEU C O   1 
ATOM   5451 C  CB  . LEU C 1 116 ? -52.351 14.631  22.415  1    53.4   ? 112 LEU C CB  1 
ATOM   5452 C  CG  . LEU C 1 116 ? -53.096 15.468  23.457  1    54.95  ? 112 LEU C CG  1 
ATOM   5453 C  CD1 . LEU C 1 116 ? -54.175 16.325  22.849  1    55.52  ? 112 LEU C CD1 1 
ATOM   5454 C  CD2 . LEU C 1 116 ? -53.696 14.554  24.505  1    56.8   ? 112 LEU C CD2 1 
ATOM   5455 N  N   . GLN C 1 117 ? -49.852 13.112  20.98   1    54.61  ? 113 GLN C N   1 
ATOM   5456 C  CA  . GLN C 1 117 ? -49.347 12.068  20.097  1    56.26  ? 113 GLN C CA  1 
ATOM   5457 C  C   . GLN C 1 117 ? -48.367 11.187  20.875  1    55     ? 113 GLN C C   1 
ATOM   5458 O  O   . GLN C 1 117 ? -48.44  9.955   20.842  1    52.2   ? 113 GLN C O   1 
ATOM   5459 C  CB  . GLN C 1 117 ? -48.676 12.681  18.868  1    56.53  ? 113 GLN C CB  1 
ATOM   5460 C  CG  . GLN C 1 117 ? -49.669 13.256  17.875  1    58.45  ? 113 GLN C CG  1 
ATOM   5461 C  CD  . GLN C 1 117 ? -49.003 13.671  16.592  1    66.89  ? 113 GLN C CD  1 
ATOM   5462 O  OE1 . GLN C 1 117 ? -48.485 12.842  15.851  1    80.79  ? 113 GLN C OE1 1 
ATOM   5463 N  NE2 . GLN C 1 117 ? -49.014 14.955  16.294  1    74.44  ? 113 GLN C NE2 1 
ATOM   5464 N  N   . GLY C 1 118 ? -47.462 11.852  21.604  1    52.02  ? 114 GLY C N   1 
ATOM   5465 C  CA  . GLY C 1 118 ? -46.507 11.171  22.445  1    47     ? 114 GLY C CA  1 
ATOM   5466 C  C   . GLY C 1 118 ? -47.213 10.318  23.493  1    48.2   ? 114 GLY C C   1 
ATOM   5467 O  O   . GLY C 1 118 ? -46.806 9.167   23.743  1    48.81  ? 114 GLY C O   1 
ATOM   5468 N  N   . LEU C 1 119 ? -48.256 10.884  24.108  1    46.48  ? 115 LEU C N   1 
ATOM   5469 C  CA  . LEU C 1 119 ? -48.908 10.213  25.219  1    49.72  ? 115 LEU C CA  1 
ATOM   5470 C  C   . LEU C 1 119 ? -49.732 9.027   24.716  1    50.65  ? 115 LEU C C   1 
ATOM   5471 O  O   . LEU C 1 119 ? -49.82  8       25.384  1    52.48  ? 115 LEU C O   1 
ATOM   5472 C  CB  . LEU C 1 119 ? -49.715 11.188  26.084  1    48.57  ? 115 LEU C CB  1 
ATOM   5473 C  CG  . LEU C 1 119 ? -50.439 10.536  27.265  1    48.74  ? 115 LEU C CG  1 
ATOM   5474 C  CD1 . LEU C 1 119 ? -49.448 9.92    28.263  1    45.17  ? 115 LEU C CD1 1 
ATOM   5475 C  CD2 . LEU C 1 119 ? -51.357 11.53   27.933  1    48.92  ? 115 LEU C CD2 1 
ATOM   5476 N  N   . ALA C 1 120 ? -50.341 9.189   23.533  1    54.08  ? 116 ALA C N   1 
ATOM   5477 C  CA  . ALA C 1 120 ? -51.117 8.138   22.892  1    52.29  ? 116 ALA C CA  1 
ATOM   5478 C  C   . ALA C 1 120 ? -50.215 6.947   22.54   1    51.24  ? 116 ALA C C   1 
ATOM   5479 O  O   . ALA C 1 120 ? -50.596 5.788   22.719  1    53.56  ? 116 ALA C O   1 
ATOM   5480 C  CB  . ALA C 1 120 ? -51.828 8.714   21.692  1    51.46  ? 116 ALA C CB  1 
ATOM   5481 N  N   . PHE C 1 121 ? -49.003 7.222   22.054  1    48.06  ? 117 PHE C N   1 
ATOM   5482 C  CA  . PHE C 1 121 ? -47.989 6.187   21.891  1    48.24  ? 117 PHE C CA  1 
ATOM   5483 C  C   . PHE C 1 121 ? -47.653 5.474   23.214  1    48.56  ? 117 PHE C C   1 
ATOM   5484 O  O   . PHE C 1 121 ? -47.5   4.244   23.224  1    50.41  ? 117 PHE C O   1 
ATOM   5485 C  CB  . PHE C 1 121 ? -46.726 6.804   21.297  1    47.35  ? 117 PHE C CB  1 
ATOM   5486 C  CG  . PHE C 1 121 ? -45.801 5.762   20.684  1    52.08  ? 117 PHE C CG  1 
ATOM   5487 C  CD1 . PHE C 1 121 ? -44.818 5.137   21.458  1    43.25  ? 117 PHE C CD1 1 
ATOM   5488 C  CD2 . PHE C 1 121 ? -45.946 5.403   19.324  1    49.78  ? 117 PHE C CD2 1 
ATOM   5489 C  CE1 . PHE C 1 121 ? -43.994 4.193   20.862  1    44.8   ? 117 PHE C CE1 1 
ATOM   5490 C  CE2 . PHE C 1 121 ? -45.112 4.457   18.756  1    46.93  ? 117 PHE C CE2 1 
ATOM   5491 C  CZ  . PHE C 1 121 ? -44.145 3.851   19.518  1    44.52  ? 117 PHE C CZ  1 
ATOM   5492 N  N   . CYS C 1 122 ? -47.522 6.225   24.322  1    44.17  ? 118 CYS C N   1 
ATOM   5493 C  CA  . CYS C 1 122 ? -47.293 5.582   25.61   1    46.97  ? 118 CYS C CA  1 
ATOM   5494 C  C   . CYS C 1 122 ? -48.422 4.622   25.953  1    48.88  ? 118 CYS C C   1 
ATOM   5495 O  O   . CYS C 1 122 ? -48.184 3.444   26.215  1    53.65  ? 118 CYS C O   1 
ATOM   5496 C  CB  . CYS C 1 122 ? -47.118 6.586   26.736  1    46.07  ? 118 CYS C CB  1 
ATOM   5497 S  SG  . CYS C 1 122 ? -45.586 7.522   26.519  1    49.8   ? 118 CYS C SG  1 
ATOM   5498 N  N   . HIS C 1 123 ? -49.645 5.148   25.914  1    50.7   ? 119 HIS C N   1 
ATOM   5499 C  CA  . HIS C 1 123 ? -50.853 4.405   26.223  1    53.13  ? 119 HIS C CA  1 
ATOM   5500 C  C   . HIS C 1 123 ? -51.034 3.184   25.306  1    53.26  ? 119 HIS C C   1 
ATOM   5501 O  O   . HIS C 1 123 ? -51.328 2.093   25.804  1    51.65  ? 119 HIS C O   1 
ATOM   5502 C  CB  . HIS C 1 123 ? -52.021 5.383   26.327  1    52.65  ? 119 HIS C CB  1 
ATOM   5503 C  CG  . HIS C 1 123 ? -51.872 6.318   27.48   1    57.12  ? 119 HIS C CG  1 
ATOM   5504 N  ND1 . HIS C 1 123 ? -52.681 7.422   27.665  1    58.94  ? 119 HIS C ND1 1 
ATOM   5505 C  CD2 . HIS C 1 123 ? -51.014 6.305   28.533  1    56.17  ? 119 HIS C CD2 1 
ATOM   5506 C  CE1 . HIS C 1 123 ? -52.313 8.048   28.775  1    56.33  ? 119 HIS C CE1 1 
ATOM   5507 N  NE2 . HIS C 1 123 ? -51.295 7.4     29.304  1    55.77  ? 119 HIS C NE2 1 
ATOM   5508 N  N   . SER C 1 124 ? -50.872 3.374   23.981  1    52.5   ? 120 SER C N   1 
ATOM   5509 C  CA  . SER C 1 124 ? -50.907 2.297   22.992  1    53.28  ? 120 SER C CA  1 
ATOM   5510 C  C   . SER C 1 124 ? -49.885 1.206   23.312  1    54.22  ? 120 SER C C   1 
ATOM   5511 O  O   . SER C 1 124 ? -50.003 0.088   22.811  1    53.5   ? 120 SER C O   1 
ATOM   5512 C  CB  . SER C 1 124 ? -50.596 2.79    21.605  1    54.69  ? 120 SER C CB  1 
ATOM   5513 O  OG  . SER C 1 124 ? -51.542 3.702   21.078  1    67.92  ? 120 SER C OG  1 
ATOM   5514 N  N   . HIS C 1 125 ? -48.817 1.569   24.043  1    55.96  ? 121 HIS C N   1 
ATOM   5515 C  CA  . HIS C 1 125 ? -47.734 0.644   24.36   1    55.66  ? 121 HIS C CA  1 
ATOM   5516 C  C   . HIS C 1 125 ? -47.75  0.278   25.841  1    50.82  ? 121 HIS C C   1 
ATOM   5517 O  O   . HIS C 1 125 ? -46.73  -0.079  26.383  1    51.4   ? 121 HIS C O   1 
ATOM   5518 C  CB  . HIS C 1 125 ? -46.403 1.194   23.855  1    53.42  ? 121 HIS C CB  1 
ATOM   5519 C  CG  . HIS C 1 125 ? -46.388 1.271   22.374  1    60.45  ? 121 HIS C CG  1 
ATOM   5520 N  ND1 . HIS C 1 125 ? -47.123 2.194   21.659  1    60.9   ? 121 HIS C ND1 1 
ATOM   5521 C  CD2 . HIS C 1 125 ? -45.757 0.508   21.467  1    64     ? 121 HIS C CD2 1 
ATOM   5522 C  CE1 . HIS C 1 125 ? -46.913 1.998   20.36   1    62.83  ? 121 HIS C CE1 1 
ATOM   5523 N  NE2 . HIS C 1 125 ? -46.093 0.974   20.227  1    66.01  ? 121 HIS C NE2 1 
ATOM   5524 N  N   . ARG C 1 126 ? -48.925 0.35    26.465  1    49.69  ? 122 ARG C N   1 
ATOM   5525 C  CA  . ARG C 1 126 ? -49.165 -0.081  27.834  1    49.64  ? 122 ARG C CA  1 
ATOM   5526 C  C   . ARG C 1 126 ? -48.19  0.569   28.829  1    49.36  ? 122 ARG C C   1 
ATOM   5527 O  O   . ARG C 1 126 ? -47.832 -0.066  29.814  1    51.35  ? 122 ARG C O   1 
ATOM   5528 C  CB  . ARG C 1 126 ? -49.267 -1.613  27.901  1    48.41  ? 122 ARG C CB  1 
ATOM   5529 C  CG  . ARG C 1 126 ? -48.065 -2.453  27.464  1    48.48  ? 122 ARG C CG  1 
ATOM   5530 C  CD  . ARG C 1 126 ? -47.042 -2.79   28.566  1    48.06  ? 122 ARG C CD  1 
ATOM   5531 N  NE  . ARG C 1 126 ? -45.967 -3.695  28.136  1    50.91  ? 122 ARG C NE  1 
ATOM   5532 C  CZ  . ARG C 1 126 ? -44.907 -3.321  27.357  1    48.03  ? 122 ARG C CZ  1 
ATOM   5533 N  NH1 . ARG C 1 126 ? -44.752 -2.066  26.945  1    40.99  ? 122 ARG C NH1 1 
ATOM   5534 N  NH2 . ARG C 1 126 ? -44.002 -4.218  27.005  1    44.78  ? 122 ARG C NH2 1 
ATOM   5535 N  N   . VAL C 1 127 ? -47.853 1.86    28.641  1    49.14  ? 123 VAL C N   1 
ATOM   5536 C  CA  . VAL C 1 127 ? -47.004 2.626   29.555  1    46.18  ? 123 VAL C CA  1 
ATOM   5537 C  C   . VAL C 1 127 ? -47.77  3.844   30.086  1    46.16  ? 123 VAL C C   1 
ATOM   5538 O  O   . VAL C 1 127 ? -48.203 4.716   29.326  1    46.89  ? 123 VAL C O   1 
ATOM   5539 C  CB  . VAL C 1 127 ? -45.657 3.047   28.913  1    43.58  ? 123 VAL C CB  1 
ATOM   5540 C  CG1 . VAL C 1 127 ? -44.874 4.025   29.79   1    38.86  ? 123 VAL C CG1 1 
ATOM   5541 C  CG2 . VAL C 1 127 ? -44.783 1.862   28.502  1    41.46  ? 123 VAL C CG2 1 
ATOM   5542 N  N   . LEU C 1 128 ? -47.927 3.898   31.414  1    45.22  ? 124 LEU C N   1 
ATOM   5543 C  CA  . LEU C 1 128 ? -48.339 5.13    32.075  1    45.29  ? 124 LEU C CA  1 
ATOM   5544 C  C   . LEU C 1 128 ? -47.099 5.996   32.327  1    45.35  ? 124 LEU C C   1 
ATOM   5545 O  O   . LEU C 1 128 ? -46.073 5.471   32.778  1    43.59  ? 124 LEU C O   1 
ATOM   5546 C  CB  . LEU C 1 128 ? -49.025 4.814   33.411  1    42.8   ? 124 LEU C CB  1 
ATOM   5547 C  CG  . LEU C 1 128 ? -50.336 4.042   33.381  1    46.2   ? 124 LEU C CG  1 
ATOM   5548 C  CD1 . LEU C 1 128 ? -50.801 3.86    34.832  1    47.57  ? 124 LEU C CD1 1 
ATOM   5549 C  CD2 . LEU C 1 128 ? -51.4   4.745   32.522  1    43.83  ? 124 LEU C CD2 1 
ATOM   5550 N  N   . HIS C 1 129 ? -47.222 7.321   32.142  1    44.74  ? 125 HIS C N   1 
ATOM   5551 C  CA  . HIS C 1 129 ? -46.121 8.215   32.453  1    46.42  ? 125 HIS C CA  1 
ATOM   5552 C  C   . HIS C 1 129 ? -46.096 8.55    33.945  1    48.24  ? 125 HIS C C   1 
ATOM   5553 O  O   . HIS C 1 129 ? -45.096 8.288   34.618  1    46.4   ? 125 HIS C O   1 
ATOM   5554 C  CB  . HIS C 1 129 ? -46.167 9.485   31.603  1    46.34  ? 125 HIS C CB  1 
ATOM   5555 C  CG  . HIS C 1 129 ? -44.938 10.329  31.745  1    44.59  ? 125 HIS C CG  1 
ATOM   5556 N  ND1 . HIS C 1 129 ? -44.707 11.139  32.845  1    42.75  ? 125 HIS C ND1 1 
ATOM   5557 C  CD2 . HIS C 1 129 ? -43.902 10.501  30.912  1    41.82  ? 125 HIS C CD2 1 
ATOM   5558 C  CE1 . HIS C 1 129 ? -43.552 11.766  32.682  1    43.83  ? 125 HIS C CE1 1 
ATOM   5559 N  NE2 . HIS C 1 129 ? -43.055 11.415  31.509  1    44.39  ? 125 HIS C NE2 1 
ATOM   5560 N  N   . ARG C 1 130 ? -47.166 9.197   34.434  1    46.73  ? 126 ARG C N   1 
ATOM   5561 C  CA  . ARG C 1 130 ? -47.381 9.378   35.869  1    46.76  ? 126 ARG C CA  1 
ATOM   5562 C  C   . ARG C 1 130 ? -46.552 10.526  36.451  1    46.41  ? 126 ARG C C   1 
ATOM   5563 O  O   . ARG C 1 130 ? -46.546 10.738  37.661  1    45.71  ? 126 ARG C O   1 
ATOM   5564 C  CB  . ARG C 1 130 ? -47.157 8.09    36.681  1    44.92  ? 126 ARG C CB  1 
ATOM   5565 C  CG  . ARG C 1 130 ? -47.987 6.898   36.233  1    45.68  ? 126 ARG C CG  1 
ATOM   5566 C  CD  . ARG C 1 130 ? -48.048 5.808   37.291  1    48.34  ? 126 ARG C CD  1 
ATOM   5567 N  NE  . ARG C 1 130 ? -46.721 5.269   37.61   1    47.29  ? 126 ARG C NE  1 
ATOM   5568 C  CZ  . ARG C 1 130 ? -46.484 4.321   38.512  1    50.14  ? 126 ARG C CZ  1 
ATOM   5569 N  NH1 . ARG C 1 130 ? -47.494 3.733   39.161  1    46.84  ? 126 ARG C NH1 1 
ATOM   5570 N  NH2 . ARG C 1 130 ? -45.222 3.946   38.73   1    49.38  ? 126 ARG C NH2 1 
ATOM   5571 N  N   . ASP C 1 131 ? -45.876 11.314  35.607  1    45.97  ? 127 ASP C N   1 
ATOM   5572 C  CA  . ASP C 1 131 ? -45.202 12.489  36.138  1    47.38  ? 127 ASP C CA  1 
ATOM   5573 C  C   . ASP C 1 131 ? -45.162 13.569  35.07   1    47.24  ? 127 ASP C C   1 
ATOM   5574 O  O   . ASP C 1 131 ? -44.114 14.194  34.87   1    48.3   ? 127 ASP C O   1 
ATOM   5575 C  CB  . ASP C 1 131 ? -43.789 12.194  36.628  1    46.41  ? 127 ASP C CB  1 
ATOM   5576 C  CG  . ASP C 1 131 ? -43.193 13.229  37.571  1    50.4   ? 127 ASP C CG  1 
ATOM   5577 O  OD1 . ASP C 1 131 ? -43.972 14.054  38.134  1    52     ? 127 ASP C OD1 1 
ATOM   5578 O  OD2 . ASP C 1 131 ? -41.942 13.214  37.724  1    54.14  ? 127 ASP C OD2 1 
ATOM   5579 N  N   . LEU C 1 132 ? -46.303 13.788  34.408  1    43.04  ? 128 LEU C N   1 
ATOM   5580 C  CA  . LEU C 1 132 ? -46.321 14.832  33.402  1    45.07  ? 128 LEU C CA  1 
ATOM   5581 C  C   . LEU C 1 132 ? -46.495 16.175  34.097  1    46.3   ? 128 LEU C C   1 
ATOM   5582 O  O   . LEU C 1 132 ? -47.503 16.397  34.745  1    50.3   ? 128 LEU C O   1 
ATOM   5583 C  CB  . LEU C 1 132 ? -47.392 14.574  32.346  1    44.27  ? 128 LEU C CB  1 
ATOM   5584 C  CG  . LEU C 1 132 ? -47.199 13.31   31.509  1    43.2   ? 128 LEU C CG  1 
ATOM   5585 C  CD1 . LEU C 1 132 ? -48.503 12.879  30.871  1    45.52  ? 128 LEU C CD1 1 
ATOM   5586 C  CD2 . LEU C 1 132 ? -46.153 13.527  30.461  1    42.2   ? 128 LEU C CD2 1 
ATOM   5587 N  N   . LYS C 1 133 ? -45.488 17.044  33.967  1    46.55  ? 129 LYS C N   1 
ATOM   5588 C  CA  . LYS C 1 133 ? -45.54  18.439  34.38   1    46.35  ? 129 LYS C CA  1 
ATOM   5589 C  C   . LYS C 1 133 ? -44.618 19.242  33.452  1    47.51  ? 129 LYS C C   1 
ATOM   5590 O  O   . LYS C 1 133 ? -43.755 18.684  32.784  1    48.57  ? 129 LYS C O   1 
ATOM   5591 C  CB  . LYS C 1 133 ? -45.114 18.526  35.844  1    45.99  ? 129 LYS C CB  1 
ATOM   5592 C  CG  . LYS C 1 133 ? -43.729 17.947  36.1    1    47.99  ? 129 LYS C CG  1 
ATOM   5593 C  CD  . LYS C 1 133 ? -43.317 17.961  37.569  1    51.35  ? 129 LYS C CD  1 
ATOM   5594 C  CE  . LYS C 1 133 ? -42.082 17.145  37.814  1    57.06  ? 129 LYS C CE  1 
ATOM   5595 N  NZ  . LYS C 1 133 ? -41.426 17.654  39.023  1    60.2   ? 129 LYS C NZ  1 
ATOM   5596 N  N   . PRO C 1 134 ? -44.735 20.586  33.372  1    48.8   ? 130 PRO C N   1 
ATOM   5597 C  CA  . PRO C 1 134 ? -43.909 21.362  32.427  1    49.23  ? 130 PRO C CA  1 
ATOM   5598 C  C   . PRO C 1 134 ? -42.393 21.165  32.518  1    49.73  ? 130 PRO C C   1 
ATOM   5599 O  O   . PRO C 1 134 ? -41.675 21.284  31.516  1    48.98  ? 130 PRO C O   1 
ATOM   5600 C  CB  . PRO C 1 134 ? -44.261 22.807  32.757  1    49.74  ? 130 PRO C CB  1 
ATOM   5601 C  CG  . PRO C 1 134 ? -45.588 22.723  33.493  1    48.53  ? 130 PRO C CG  1 
ATOM   5602 C  CD  . PRO C 1 134 ? -45.618 21.409  34.223  1    46.4   ? 130 PRO C CD  1 
ATOM   5603 N  N   . GLN C 1 135 ? -41.912 20.896  33.74   1    49.21  ? 131 GLN C N   1 
ATOM   5604 C  CA  . GLN C 1 135 ? -40.495 20.667  34.004  1    49.73  ? 131 GLN C CA  1 
ATOM   5605 C  C   . GLN C 1 135 ? -40.015 19.405  33.284  1    48.89  ? 131 GLN C C   1 
ATOM   5606 O  O   . GLN C 1 135 ? -38.833 19.305  32.994  1    50.56  ? 131 GLN C O   1 
ATOM   5607 C  CB  . GLN C 1 135 ? -40.194 20.524  35.494  1    47.45  ? 131 GLN C CB  1 
ATOM   5608 C  CG  . GLN C 1 135 ? -40.615 21.715  36.352  1    54.39  ? 131 GLN C CG  1 
ATOM   5609 C  CD  . GLN C 1 135 ? -42.093 21.827  36.715  1    55.96  ? 131 GLN C CD  1 
ATOM   5610 O  OE1 . GLN C 1 135 ? -42.987 21.154  36.182  1    55.8   ? 131 GLN C OE1 1 
ATOM   5611 N  NE2 . GLN C 1 135 ? -42.378 22.77   37.592  1    54.79  ? 131 GLN C NE2 1 
ATOM   5612 N  N   . ASN C 1 136 ? -40.936 18.465  32.998  1    44.59  ? 132 ASN C N   1 
ATOM   5613 C  CA  . ASN C 1 136 ? -40.596 17.159  32.462  1    42.76  ? 132 ASN C CA  1 
ATOM   5614 C  C   . ASN C 1 136 ? -40.93  17.067  30.976  1    41.61  ? 132 ASN C C   1 
ATOM   5615 O  O   . ASN C 1 136 ? -40.97  15.966  30.437  1    41.58  ? 132 ASN C O   1 
ATOM   5616 C  CB  . ASN C 1 136 ? -41.314 16.045  33.217  1    40.89  ? 132 ASN C CB  1 
ATOM   5617 C  CG  . ASN C 1 136 ? -40.724 15.787  34.586  1    43.31  ? 132 ASN C CG  1 
ATOM   5618 O  OD1 . ASN C 1 136 ? -39.598 16.223  34.883  1    45.42  ? 132 ASN C OD1 1 
ATOM   5619 N  ND2 . ASN C 1 136 ? -41.448 15.054  35.424  1    40.8   ? 132 ASN C ND2 1 
ATOM   5620 N  N   . LEU C 1 137 ? -41.21  18.207  30.323  1    40.89  ? 133 LEU C N   1 
ATOM   5621 C  CA  . LEU C 1 137 ? -41.45  18.239  28.885  1    39.91  ? 133 LEU C CA  1 
ATOM   5622 C  C   . LEU C 1 137 ? -40.37  19.103  28.233  1    42.7   ? 133 LEU C C   1 
ATOM   5623 O  O   . LEU C 1 137 ? -40.115 20.216  28.708  1    45     ? 133 LEU C O   1 
ATOM   5624 C  CB  . LEU C 1 137 ? -42.825 18.849  28.671  1    39.89  ? 133 LEU C CB  1 
ATOM   5625 C  CG  . LEU C 1 137 ? -43.985 18.175  29.407  1    41.22  ? 133 LEU C CG  1 
ATOM   5626 C  CD1 . LEU C 1 137 ? -45.287 18.932  29.106  1    41.29  ? 133 LEU C CD1 1 
ATOM   5627 C  CD2 . LEU C 1 137 ? -44.097 16.704  28.992  1    40.89  ? 133 LEU C CD2 1 
ATOM   5628 N  N   . LEU C 1 138 ? -39.748 18.592  27.162  1    42.3   ? 134 LEU C N   1 
ATOM   5629 C  CA  . LEU C 1 138 ? -38.594 19.239  26.544  1    45.5   ? 134 LEU C CA  1 
ATOM   5630 C  C   . LEU C 1 138 ? -38.963 19.794  25.177  1    45.78  ? 134 LEU C C   1 
ATOM   5631 O  O   . LEU C 1 138 ? -39.703 19.151  24.441  1    50.42  ? 134 LEU C O   1 
ATOM   5632 C  CB  . LEU C 1 138 ? -37.462 18.219  26.406  1    46.08  ? 134 LEU C CB  1 
ATOM   5633 C  CG  . LEU C 1 138 ? -37.071 17.484  27.701  1    45.85  ? 134 LEU C CG  1 
ATOM   5634 C  CD1 . LEU C 1 138 ? -36.036 16.401  27.388  1    44.38  ? 134 LEU C CD1 1 
ATOM   5635 C  CD2 . LEU C 1 138 ? -36.588 18.393  28.828  1    41.18  ? 134 LEU C CD2 1 
ATOM   5636 N  N   . ILE C 1 139 ? -38.45  20.99   24.854  1    44.99  ? 135 ILE C N   1 
ATOM   5637 C  CA  . ILE C 1 139 ? -38.707 21.629  23.571  1    45.5   ? 135 ILE C CA  1 
ATOM   5638 C  C   . ILE C 1 139 ? -37.361 21.874  22.897  1    49.24  ? 135 ILE C C   1 
ATOM   5639 O  O   . ILE C 1 139 ? -36.394 22.203  23.576  1    48.29  ? 135 ILE C O   1 
ATOM   5640 C  CB  . ILE C 1 139 ? -39.455 22.97   23.753  1    47.3   ? 135 ILE C CB  1 
ATOM   5641 C  CG1 . ILE C 1 139 ? -38.7   23.931  24.684  1    47.8   ? 135 ILE C CG1 1 
ATOM   5642 C  CG2 . ILE C 1 139 ? -40.892 22.742  24.219  1    47.15  ? 135 ILE C CG2 1 
ATOM   5643 C  CD1 . ILE C 1 139 ? -39.145 25.384  24.618  1    52.92  ? 135 ILE C CD1 1 
ATOM   5644 N  N   . ASN C 1 140 ? -37.317 21.774  21.558  1    54.74  ? 136 ASN C N   1 
ATOM   5645 C  CA  . ASN C 1 140 ? -36.184 22.277  20.784  1    58.25  ? 136 ASN C CA  1 
ATOM   5646 C  C   . ASN C 1 140 ? -36.533 23.609  20.103  1    62.04  ? 136 ASN C C   1 
ATOM   5647 O  O   . ASN C 1 140 ? -37.639 24.146  20.279  1    64.98  ? 136 ASN C O   1 
ATOM   5648 C  CB  . ASN C 1 140 ? -35.667 21.245  19.787  1    58.44  ? 136 ASN C CB  1 
ATOM   5649 C  CG  . ASN C 1 140 ? -36.701 20.828  18.757  1    55.87  ? 136 ASN C CG  1 
ATOM   5650 O  OD1 . ASN C 1 140 ? -37.665 21.549  18.483  1    56.11  ? 136 ASN C OD1 1 
ATOM   5651 N  ND2 . ASN C 1 140 ? -36.533 19.656  18.177  1    54.16  ? 136 ASN C ND2 1 
ATOM   5652 N  N   . THR C 1 141 ? -35.556 24.11   19.333  1    64.38  ? 137 THR C N   1 
ATOM   5653 C  CA  . THR C 1 141 ? -35.597 25.403  18.668  1    73.14  ? 137 THR C CA  1 
ATOM   5654 C  C   . THR C 1 141 ? -36.449 25.347  17.401  1    73.74  ? 137 THR C C   1 
ATOM   5655 O  O   . THR C 1 141 ? -36.679 26.39   16.781  1    77.97  ? 137 THR C O   1 
ATOM   5656 C  CB  . THR C 1 141 ? -34.196 25.922  18.328  1    74.43  ? 137 THR C CB  1 
ATOM   5657 O  OG1 . THR C 1 141 ? -33.635 24.971  17.436  1    87.33  ? 137 THR C OG1 1 
ATOM   5658 C  CG2 . THR C 1 141 ? -33.253 26.002  19.507  1    70.15  ? 137 THR C CG2 1 
ATOM   5659 N  N   . GLU C 1 142 ? -36.892 24.143  17.011  1    69.87  ? 138 GLU C N   1 
ATOM   5660 C  CA  . GLU C 1 142 ? -37.595 23.954  15.747  1    74.05  ? 138 GLU C CA  1 
ATOM   5661 C  C   . GLU C 1 142 ? -39.056 23.509  15.909  1    71.95  ? 138 GLU C C   1 
ATOM   5662 O  O   . GLU C 1 142 ? -39.63  22.994  14.947  1    68.53  ? 138 GLU C O   1 
ATOM   5663 C  CB  . GLU C 1 142 ? -36.801 22.964  14.898  1    76.31  ? 138 GLU C CB  1 
ATOM   5664 C  CG  . GLU C 1 142 ? -35.4   23.473  14.573  1    87.76  ? 138 GLU C CG  1 
ATOM   5665 C  CD  . GLU C 1 142 ? -34.725 22.885  13.346  1    99.68  ? 138 GLU C CD  1 
ATOM   5666 O  OE1 . GLU C 1 142 ? -34.692 21.627  13.259  1    96.6   ? 138 GLU C OE1 1 
ATOM   5667 O  OE2 . GLU C 1 142 ? -34.238 23.681  12.496  1    91.6   ? 138 GLU C OE2 1 
ATOM   5668 N  N   . GLY C 1 143 ? -39.647 23.667  17.113  1    63.82  ? 139 GLY C N   1 
ATOM   5669 C  CA  . GLY C 1 143 ? -41.09  23.54   17.293  1    60.49  ? 139 GLY C CA  1 
ATOM   5670 C  C   . GLY C 1 143 ? -41.55  22.185  17.854  1    63.57  ? 139 GLY C C   1 
ATOM   5671 O  O   . GLY C 1 143 ? -42.763 21.951  17.987  1    61.47  ? 139 GLY C O   1 
ATOM   5672 N  N   . ALA C 1 144 ? -40.603 21.278  18.169  1    57.48  ? 140 ALA C N   1 
ATOM   5673 C  CA  . ALA C 1 144 ? -40.969 20.003  18.78   1    54.99  ? 140 ALA C CA  1 
ATOM   5674 C  C   . ALA C 1 144 ? -41.073 20.163  20.29   1    53.82  ? 140 ALA C C   1 
ATOM   5675 O  O   . ALA C 1 144 ? -40.393 21.021  20.871  1    52.32  ? 140 ALA C O   1 
ATOM   5676 C  CB  . ALA C 1 144 ? -39.938 18.938  18.482  1    54.38  ? 140 ALA C CB  1 
ATOM   5677 N  N   . ILE C 1 145 ? -41.93  19.316  20.882  1    51.88  ? 141 ILE C N   1 
ATOM   5678 C  CA  . ILE C 1 145 ? -41.953 19.052  22.312  1    52.86  ? 141 ILE C CA  1 
ATOM   5679 C  C   . ILE C 1 145 ? -41.951 17.543  22.516  1    52.42  ? 141 ILE C C   1 
ATOM   5680 O  O   . ILE C 1 145 ? -42.519 16.824  21.71   1    56.9   ? 141 ILE C O   1 
ATOM   5681 C  CB  . ILE C 1 145 ? -43.165 19.707  22.995  1    53.83  ? 141 ILE C CB  1 
ATOM   5682 C  CG1 . ILE C 1 145 ? -43.071 19.626  24.521  1    52.79  ? 141 ILE C CG1 1 
ATOM   5683 C  CG2 . ILE C 1 145 ? -44.478 19.128  22.475  1    56.1   ? 141 ILE C CG2 1 
ATOM   5684 C  CD1 . ILE C 1 145 ? -43.93  20.668  25.23   1    53.71  ? 141 ILE C CD1 1 
ATOM   5685 N  N   . LYS C 1 146 ? -41.334 17.081  23.604  1    50.98  ? 142 LYS C N   1 
ATOM   5686 C  CA  . LYS C 1 146 ? -41.234 15.66   23.894  1    46.77  ? 142 LYS C CA  1 
ATOM   5687 C  C   . LYS C 1 146 ? -41.438 15.404  25.391  1    46.08  ? 142 LYS C C   1 
ATOM   5688 O  O   . LYS C 1 146 ? -40.987 16.193  26.224  1    44.1   ? 142 LYS C O   1 
ATOM   5689 C  CB  . LYS C 1 146 ? -39.863 15.107  23.475  1    44.61  ? 142 LYS C CB  1 
ATOM   5690 C  CG  . LYS C 1 146 ? -39.449 15.534  22.099  1    45.34  ? 142 LYS C CG  1 
ATOM   5691 C  CD  . LYS C 1 146 ? -38.244 14.775  21.589  1    46.57  ? 142 LYS C CD  1 
ATOM   5692 C  CE  . LYS C 1 146 ? -37.829 15.268  20.192  1    49.3   ? 142 LYS C CE  1 
ATOM   5693 N  NZ  . LYS C 1 146 ? -37.085 14.196  19.51   1    46.32  ? 142 LYS C NZ  1 
ATOM   5694 N  N   . LEU C 1 147 ? -42.144 14.296  25.685  1    44.93  ? 143 LEU C N   1 
ATOM   5695 C  CA  . LEU C 1 147 ? -42.246 13.702  27.002  1    44.81  ? 143 LEU C CA  1 
ATOM   5696 C  C   . LEU C 1 147 ? -40.846 13.281  27.444  1    44.31  ? 143 LEU C C   1 
ATOM   5697 O  O   . LEU C 1 147 ? -40.126 12.609  26.709  1    42.7   ? 143 LEU C O   1 
ATOM   5698 C  CB  . LEU C 1 147 ? -43.187 12.492  27.031  1    43.23  ? 143 LEU C CB  1 
ATOM   5699 C  CG  . LEU C 1 147 ? -44.572 12.619  26.397  1    46.45  ? 143 LEU C CG  1 
ATOM   5700 C  CD1 . LEU C 1 147 ? -45.458 11.467  26.869  1    50.17  ? 143 LEU C CD1 1 
ATOM   5701 C  CD2 . LEU C 1 147 ? -45.248 13.92   26.711  1    48.47  ? 143 LEU C CD2 1 
ATOM   5702 N  N   . ALA C 1 148 ? -40.488 13.66   28.667  1    41.21  ? 144 ALA C N   1 
ATOM   5703 C  CA  . ALA C 1 148 ? -39.242 13.197  29.232  1    42.48  ? 144 ALA C CA  1 
ATOM   5704 C  C   . ALA C 1 148 ? -39.49  12.824  30.686  1    43.42  ? 144 ALA C C   1 
ATOM   5705 O  O   . ALA C 1 148 ? -40.646 12.754  31.115  1    43.51  ? 144 ALA C O   1 
ATOM   5706 C  CB  . ALA C 1 148 ? -38.19  14.252  29.063  1    43.22  ? 144 ALA C CB  1 
ATOM   5707 N  N   . ASP C 1 149 ? -38.394 12.552  31.4    1    44.54  ? 145 ASP C N   1 
ATOM   5708 C  CA  . ASP C 1 149 ? -38.379 11.96   32.725  1    42.34  ? 145 ASP C CA  1 
ATOM   5709 C  C   . ASP C 1 149 ? -39.406 10.839  32.878  1    43.62  ? 145 ASP C C   1 
ATOM   5710 O  O   . ASP C 1 149 ? -40.477 11.048  33.436  1    47.77  ? 145 ASP C O   1 
ATOM   5711 C  CB  . ASP C 1 149 ? -38.505 13.005  33.809  1    44.85  ? 145 ASP C CB  1 
ATOM   5712 C  CG  . ASP C 1 149 ? -38.008 12.511  35.159  1    53.46  ? 145 ASP C CG  1 
ATOM   5713 O  OD1 . ASP C 1 149 ? -37.81  11.258  35.313  1    54.53  ? 145 ASP C OD1 1 
ATOM   5714 O  OD2 . ASP C 1 149 ? -37.798 13.376  36.04   1    57.27  ? 145 ASP C OD2 1 
ATOM   5715 N  N   . PHE C 1 150 ? -39.054 9.647   32.396  1    44.66  ? 146 PHE C N   1 
ATOM   5716 C  CA  . PHE C 1 150 ? -39.844 8.441   32.608  1    44.95  ? 146 PHE C CA  1 
ATOM   5717 C  C   . PHE C 1 150 ? -39.468 7.706   33.899  1    44.02  ? 146 PHE C C   1 
ATOM   5718 O  O   . PHE C 1 150 ? -39.75  6.518   33.997  1    46.22  ? 146 PHE C O   1 
ATOM   5719 C  CB  . PHE C 1 150 ? -39.652 7.5     31.416  1    43.46  ? 146 PHE C CB  1 
ATOM   5720 C  CG  . PHE C 1 150 ? -40.482 7.962   30.233  1    42.21  ? 146 PHE C CG  1 
ATOM   5721 C  CD1 . PHE C 1 150 ? -40.163 9.145   29.569  1    40.41  ? 146 PHE C CD1 1 
ATOM   5722 C  CD2 . PHE C 1 150 ? -41.594 7.228   29.832  1    40.45  ? 146 PHE C CD2 1 
ATOM   5723 C  CE1 . PHE C 1 150 ? -40.923 9.57    28.488  1    40.22  ? 146 PHE C CE1 1 
ATOM   5724 C  CE2 . PHE C 1 150 ? -42.364 7.67    28.763  1    40.81  ? 146 PHE C CE2 1 
ATOM   5725 C  CZ  . PHE C 1 150 ? -42.032 8.829   28.095  1    40.97  ? 146 PHE C CZ  1 
ATOM   5726 N  N   . GLY C 1 151 ? -38.947 8.423   34.913  1    42.98  ? 147 GLY C N   1 
ATOM   5727 C  CA  . GLY C 1 151 ? -38.514 7.814   36.169  1    47.03  ? 147 GLY C CA  1 
ATOM   5728 C  C   . GLY C 1 151 ? -39.643 7.244   37.026  1    45.99  ? 147 GLY C C   1 
ATOM   5729 O  O   . GLY C 1 151 ? -39.38  6.46    37.923  1    52.09  ? 147 GLY C O   1 
ATOM   5730 N  N   . LEU C 1 152 ? -40.888 7.649   36.753  1    46.16  ? 148 LEU C N   1 
ATOM   5731 C  CA  . LEU C 1 152 ? -42.043 7.184   37.498  1    48.15  ? 148 LEU C CA  1 
ATOM   5732 C  C   . LEU C 1 152 ? -42.952 6.387   36.572  1    51.92  ? 148 LEU C C   1 
ATOM   5733 O  O   . LEU C 1 152 ? -44.059 5.991   36.966  1    54.85  ? 148 LEU C O   1 
ATOM   5734 C  CB  . LEU C 1 152 ? -42.811 8.362   38.092  1    51.65  ? 148 LEU C CB  1 
ATOM   5735 C  CG  . LEU C 1 152 ? -42.249 9.019   39.358  1    51.58  ? 148 LEU C CG  1 
ATOM   5736 C  CD1 . LEU C 1 152 ? -43.306 9.971   39.893  1    50.51  ? 148 LEU C CD1 1 
ATOM   5737 C  CD2 . LEU C 1 152 ? -41.97  7.944   40.396  1    52.18  ? 148 LEU C CD2 1 
ATOM   5738 N  N   . ALA C 1 153 ? -42.494 6.178   35.335  1    46.65  ? 149 ALA C N   1 
ATOM   5739 C  CA  . ALA C 1 153 ? -43.292 5.445   34.367  1    48.64  ? 149 ALA C CA  1 
ATOM   5740 C  C   . ALA C 1 153 ? -43.485 4.008   34.836  1    50.45  ? 149 ALA C C   1 
ATOM   5741 O  O   . ALA C 1 153 ? -42.694 3.525   35.645  1    55.05  ? 149 ALA C O   1 
ATOM   5742 C  CB  . ALA C 1 153 ? -42.609 5.495   33.02   1    50.55  ? 149 ALA C CB  1 
ATOM   5743 N  N   . ARG C 1 154 ? -44.567 3.389   34.293  1    48.67  ? 150 ARG C N   1 
ATOM   5744 C  CA  . ARG C 1 154 ? -44.883 1.987   34.64   1    49.82  ? 150 ARG C CA  1 
ATOM   5745 C  C   . ARG C 1 154 ? -45.601 1.271   33.493  1    51.08  ? 150 ARG C C   1 
ATOM   5746 O  O   . ARG C 1 154 ? -46.489 1.88    32.877  1    49.48  ? 150 ARG C O   1 
ATOM   5747 C  CB  . ARG C 1 154 ? -45.811 1.931   35.85   1    55.57  ? 150 ARG C CB  1 
ATOM   5748 C  CG  . ARG C 1 154 ? -45.57  0.741   36.763  1    61.37  ? 150 ARG C CG  1 
ATOM   5749 C  CD  . ARG C 1 154 ? -46.789 0.559   37.632  1    62.34  ? 150 ARG C CD  1 
ATOM   5750 N  NE  . ARG C 1 154 ? -47.044 -0.858  37.896  1    58.54  ? 150 ARG C NE  1 
ATOM   5751 C  CZ  . ARG C 1 154 ? -46.346 -1.591  38.74   1    54.46  ? 150 ARG C CZ  1 
ATOM   5752 N  NH1 . ARG C 1 154 ? -45.735 -2.671  38.303  1    52.93  ? 150 ARG C NH1 1 
ATOM   5753 N  NH2 . ARG C 1 154 ? -46.266 -1.246  40.009  1    54.57  ? 150 ARG C NH2 1 
ATOM   5754 N  N   . ALA C 1 155 ? -45.166 0.02    33.195  1    47.51  ? 151 ALA C N   1 
ATOM   5755 C  CA  . ALA C 1 155 ? -45.895 -0.795  32.24   1    47.64  ? 151 ALA C CA  1 
ATOM   5756 C  C   . ALA C 1 155 ? -47.136 -1.353  32.94   1    51.38  ? 151 ALA C C   1 
ATOM   5757 O  O   . ALA C 1 155 ? -47.038 -1.911  34.031  1    55.13  ? 151 ALA C O   1 
ATOM   5758 C  CB  . ALA C 1 155 ? -44.998 -1.894  31.704  1    45.82  ? 151 ALA C CB  1 
ATOM   5759 N  N   . PHE C 1 156 ? -48.312 -1.171  32.33   1    53.13  ? 152 PHE C N   1 
ATOM   5760 C  CA  . PHE C 1 156 ? -49.549 -1.611  32.962  1    54.49  ? 152 PHE C CA  1 
ATOM   5761 C  C   . PHE C 1 156 ? -50.086 -2.871  32.296  1    54.84  ? 152 PHE C C   1 
ATOM   5762 O  O   . PHE C 1 156 ? -49.707 -3.2    31.176  1    53.53  ? 152 PHE C O   1 
ATOM   5763 C  CB  . PHE C 1 156 ? -50.603 -0.504  33.044  1    52.42  ? 152 PHE C CB  1 
ATOM   5764 C  CG  . PHE C 1 156 ? -51.085 0.095   31.745  1    51.39  ? 152 PHE C CG  1 
ATOM   5765 C  CD1 . PHE C 1 156 ? -50.424 1.185   31.166  1    52.76  ? 152 PHE C CD1 1 
ATOM   5766 C  CD2 . PHE C 1 156 ? -52.239 -0.396  31.144  1    51.74  ? 152 PHE C CD2 1 
ATOM   5767 C  CE1 . PHE C 1 156 ? -50.905 1.742   29.98   1    53.65  ? 152 PHE C CE1 1 
ATOM   5768 C  CE2 . PHE C 1 156 ? -52.719 0.153   29.951  1    52.32  ? 152 PHE C CE2 1 
ATOM   5769 C  CZ  . PHE C 1 156 ? -52.049 1.215   29.366  1    54.83  ? 152 PHE C CZ  1 
ATOM   5770 N  N   . GLY C 1 157 ? -50.938 -3.588  33.038  1    57.66  ? 153 GLY C N   1 
ATOM   5771 C  CA  . GLY C 1 157 ? -51.71  -4.702  32.499  1    59.42  ? 153 GLY C CA  1 
ATOM   5772 C  C   . GLY C 1 157 ? -53.149 -4.26   32.238  1    61.1   ? 153 GLY C C   1 
ATOM   5773 O  O   . GLY C 1 157 ? -53.557 -3.182  32.701  1    61.71  ? 153 GLY C O   1 
ATOM   5774 N  N   . VAL C 1 158 ? -53.902 -5.1    31.508  1    61.08  ? 154 VAL C N   1 
ATOM   5775 C  CA  . VAL C 1 158 ? -55.294 -4.823  31.169  1    61.32  ? 154 VAL C CA  1 
ATOM   5776 C  C   . VAL C 1 158 ? -56.169 -5.956  31.695  1    64.23  ? 154 VAL C C   1 
ATOM   5777 O  O   . VAL C 1 158 ? -56.002 -7.088  31.247  1    68.3   ? 154 VAL C O   1 
ATOM   5778 C  CB  . VAL C 1 158 ? -55.449 -4.693  29.642  1    61.59  ? 154 VAL C CB  1 
ATOM   5779 C  CG1 . VAL C 1 158 ? -56.915 -4.554  29.216  1    60.49  ? 154 VAL C CG1 1 
ATOM   5780 C  CG2 . VAL C 1 158 ? -54.551 -3.602  29.059  1    56.36  ? 154 VAL C CG2 1 
ATOM   5781 N  N   . PRO C 1 159 ? -57.116 -5.733  32.645  1    66.44  ? 155 PRO C N   1 
ATOM   5782 C  CA  . PRO C 1 159 ? -57.304 -4.439  33.317  1    67.25  ? 155 PRO C CA  1 
ATOM   5783 C  C   . PRO C 1 159 ? -56.211 -4.066  34.316  1    66.24  ? 155 PRO C C   1 
ATOM   5784 O  O   . PRO C 1 159 ? -55.503 -4.938  34.816  1    69.53  ? 155 PRO C O   1 
ATOM   5785 C  CB  . PRO C 1 159 ? -58.654 -4.63   34.062  1    65.9   ? 155 PRO C CB  1 
ATOM   5786 C  CG  . PRO C 1 159 ? -58.75  -6.12   34.309  1    67.11  ? 155 PRO C CG  1 
ATOM   5787 C  CD  . PRO C 1 159 ? -58.081 -6.752  33.105  1    66     ? 155 PRO C CD  1 
ATOM   5788 N  N   . VAL C 1 160 ? -56.129 -2.771  34.633  1    65.36  ? 156 VAL C N   1 
ATOM   5789 C  CA  . VAL C 1 160 ? -55.113 -2.243  35.532  1    66.1   ? 156 VAL C CA  1 
ATOM   5790 C  C   . VAL C 1 160 ? -55.31  -2.891  36.9    1    70.69  ? 156 VAL C C   1 
ATOM   5791 O  O   . VAL C 1 160 ? -56.443 -3.176  37.303  1    77.15  ? 156 VAL C O   1 
ATOM   5792 C  CB  . VAL C 1 160 ? -55.156 -0.697  35.64   1    61.71  ? 156 VAL C CB  1 
ATOM   5793 C  CG1 . VAL C 1 160 ? -55.088 0.008   34.297  1    59.94  ? 156 VAL C CG1 1 
ATOM   5794 C  CG2 . VAL C 1 160 ? -56.366 -0.186  36.392  1    61.27  ? 156 VAL C CG2 1 
ATOM   5795 N  N   . ARG C 1 161 ? -54.209 -3.133  37.612  1    70.88  ? 157 ARG C N   1 
ATOM   5796 C  CA  . ARG C 1 161 ? -54.313 -3.419  39.042  1    75.59  ? 157 ARG C CA  1 
ATOM   5797 C  C   . ARG C 1 161 ? -53.897 -2.169  39.829  1    67.95  ? 157 ARG C C   1 
ATOM   5798 O  O   . ARG C 1 161 ? -53.628 -1.125  39.229  1    64.73  ? 157 ARG C O   1 
ATOM   5799 C  CB  . ARG C 1 161 ? -53.645 -4.754  39.418  1    77.14  ? 157 ARG C CB  1 
ATOM   5800 C  CG  . ARG C 1 161 ? -52.133 -4.789  39.248  1    76.21  ? 157 ARG C CG  1 
ATOM   5801 C  CD  . ARG C 1 161 ? -51.486 -6.022  39.886  1    79.12  ? 157 ARG C CD  1 
ATOM   5802 N  NE  . ARG C 1 161 ? -50.266 -5.603  40.595  1    77.39  ? 157 ARG C NE  1 
ATOM   5803 C  CZ  . ARG C 1 161 ? -49.129 -5.309  40.008  1    70.93  ? 157 ARG C CZ  1 
ATOM   5804 N  NH1 . ARG C 1 161 ? -48.938 -5.745  38.79   1    75.1   ? 157 ARG C NH1 1 
ATOM   5805 N  NH2 . ARG C 1 161 ? -48.186 -4.647  40.648  1    66.36  ? 157 ARG C NH2 1 
ATOM   5806 N  N   . THR C 1 162 ? -53.874 -2.29   41.165  1    64.56  ? 158 THR C N   1 
ATOM   5807 C  CA  . THR C 1 162 ? -53.407 -1.229  42.049  1    61.55  ? 158 THR C CA  1 
ATOM   5808 C  C   . THR C 1 162 ? -51.91  -0.988  41.828  1    58.08  ? 158 THR C C   1 
ATOM   5809 O  O   . THR C 1 162 ? -51.108 -1.923  41.906  1    55.95  ? 158 THR C O   1 
ATOM   5810 C  CB  . THR C 1 162 ? -53.706 -1.562  43.509  1    62.22  ? 158 THR C CB  1 
ATOM   5811 O  OG1 . THR C 1 162 ? -55.123 -1.633  43.59   1    65.56  ? 158 THR C OG1 1 
ATOM   5812 C  CG2 . THR C 1 162 ? -53.196 -0.502  44.475  1    60.55  ? 158 THR C CG2 1 
ATOM   5813 N  N   . TYR C 1 163 ? -51.577 0.278   41.526  1    55.3   ? 159 TYR C N   1 
ATOM   5814 C  CA  . TYR C 1 163 ? -50.216 0.751   41.338  1    53.71  ? 159 TYR C CA  1 
ATOM   5815 C  C   . TYR C 1 163 ? -49.858 1.687   42.494  1    54.99  ? 159 TYR C C   1 
ATOM   5816 O  O   . TYR C 1 163 ? -50.636 1.831   43.444  1    55.01  ? 159 TYR C O   1 
ATOM   5817 C  CB  . TYR C 1 163 ? -50.057 1.365   39.942  1    53.12  ? 159 TYR C CB  1 
ATOM   5818 C  CG  . TYR C 1 163 ? -50.416 0.447   38.781  1    55.27  ? 159 TYR C CG  1 
ATOM   5819 C  CD1 . TYR C 1 163 ? -50.08  -0.906  38.784  1    57.51  ? 159 TYR C CD1 1 
ATOM   5820 C  CD2 . TYR C 1 163 ? -51.104 0.932   37.676  1    57.49  ? 159 TYR C CD2 1 
ATOM   5821 C  CE1 . TYR C 1 163 ? -50.425 -1.75   37.741  1    58.3   ? 159 TYR C CE1 1 
ATOM   5822 C  CE2 . TYR C 1 163 ? -51.466 0.094   36.629  1    57.98  ? 159 TYR C CE2 1 
ATOM   5823 C  CZ  . TYR C 1 163 ? -51.105 -1.242  36.647  1    57.14  ? 159 TYR C CZ  1 
ATOM   5824 O  OH  . TYR C 1 163 ? -51.46  -2.046  35.601  1    56.98  ? 159 TYR C OH  1 
HETATM 5825 N  N   . TPO C 1 164 ? -48.651 2.278   42.427  1    56.03  ? 160 TPO C N   1 
HETATM 5826 C  CA  . TPO C 1 164 ? -48.107 3.088   43.509  1    57.67  ? 160 TPO C CA  1 
HETATM 5827 C  CB  . TPO C 1 164 ? -46.668 3.497   43.194  1    57.57  ? 160 TPO C CB  1 
HETATM 5828 C  CG2 . TPO C 1 164 ? -46.049 4.323   44.295  1    58.31  ? 160 TPO C CG2 1 
HETATM 5829 O  OG1 . TPO C 1 164 ? -45.857 2.291   43.026  1    57.43  ? 160 TPO C OG1 1 
HETATM 5830 P  P   . TPO C 1 164 ? -45.316 1.841   41.565  1    53.45  ? 160 TPO C P   1 
HETATM 5831 O  O1P . TPO C 1 164 ? -46.577 1.589   40.764  1    56.74  ? 160 TPO C O1P 1 
HETATM 5832 O  O2P . TPO C 1 164 ? -44.48  0.613   41.865  1    51.6   ? 160 TPO C O2P 1 
HETATM 5833 O  O3P . TPO C 1 164 ? -44.523 2.938   40.964  1    50.28  ? 160 TPO C O3P 1 
HETATM 5834 C  C   . TPO C 1 164 ? -48.93  4.366   43.649  1    60.22  ? 160 TPO C C   1 
HETATM 5835 O  O   . TPO C 1 164 ? -49.298 4.983   42.642  1    59.22  ? 160 TPO C O   1 
ATOM   5836 N  N   . HIS C 1 165 ? -49.221 4.752   44.898  1    63.02  ? 161 HIS C N   1 
ATOM   5837 C  CA  . HIS C 1 165 ? -50.12  5.869   45.14   1    65.69  ? 161 HIS C CA  1 
ATOM   5838 C  C   . HIS C 1 165 ? -49.387 7.192   44.952  1    64.81  ? 161 HIS C C   1 
ATOM   5839 O  O   . HIS C 1 165 ? -49.937 8.137   44.378  1    61.81  ? 161 HIS C O   1 
ATOM   5840 C  CB  . HIS C 1 165 ? -50.754 5.792   46.53   1    71.95  ? 161 HIS C CB  1 
ATOM   5841 C  CG  . HIS C 1 165 ? -51.637 6.97    46.808  1    84.56  ? 161 HIS C CG  1 
ATOM   5842 N  ND1 . HIS C 1 165 ? -51.246 8.026   47.614  1    78.79  ? 161 HIS C ND1 1 
ATOM   5843 C  CD2 . HIS C 1 165 ? -52.879 7.27    46.37   1    86.25  ? 161 HIS C CD2 1 
ATOM   5844 C  CE1 . HIS C 1 165 ? -52.221 8.92    47.673  1    84.24  ? 161 HIS C CE1 1 
ATOM   5845 N  NE2 . HIS C 1 165 ? -53.218 8.488   46.922  1    90.65  ? 161 HIS C NE2 1 
ATOM   5846 N  N   . GLU C 1 166 ? -48.132 7.223   45.415  1    66.89  ? 162 GLU C N   1 
ATOM   5847 C  CA  . GLU C 1 166 ? -47.331 8.442   45.452  1    68.29  ? 162 GLU C CA  1 
ATOM   5848 C  C   . GLU C 1 166 ? -46.804 8.719   44.046  1    69.11  ? 162 GLU C C   1 
ATOM   5849 O  O   . GLU C 1 166 ? -45.627 8.476   43.753  1    65.84  ? 162 GLU C O   1 
ATOM   5850 C  CB  . GLU C 1 166 ? -46.153 8.366   46.433  1    71.34  ? 162 GLU C CB  1 
ATOM   5851 C  CG  . GLU C 1 166 ? -46.521 8.009   47.874  1    82.95  ? 162 GLU C CG  1 
ATOM   5852 C  CD  . GLU C 1 166 ? -47.005 6.584   48.176  1    94.53  ? 162 GLU C CD  1 
ATOM   5853 O  OE1 . GLU C 1 166 ? -48.041 6.468   48.881  1    95.97  ? 162 GLU C OE1 1 
ATOM   5854 O  OE2 . GLU C 1 166 ? -46.373 5.578   47.744  1    96.3   ? 162 GLU C OE2 1 
ATOM   5855 N  N   . VAL C 1 167 ? -47.689 9.218   43.171  1    67.89  ? 163 VAL C N   1 
ATOM   5856 C  CA  . VAL C 1 167 ? -47.316 9.465   41.783  1    66.46  ? 163 VAL C CA  1 
ATOM   5857 C  C   . VAL C 1 167 ? -47.896 10.819  41.379  1    68.39  ? 163 VAL C C   1 
ATOM   5858 O  O   . VAL C 1 167 ? -48.953 11.229  41.899  1    66.02  ? 163 VAL C O   1 
ATOM   5859 C  CB  . VAL C 1 167 ? -47.755 8.348   40.808  1    60.17  ? 163 VAL C CB  1 
ATOM   5860 C  CG1 . VAL C 1 167 ? -47.116 7.015   41.136  1    56.58  ? 163 VAL C CG1 1 
ATOM   5861 C  CG2 . VAL C 1 167 ? -49.264 8.163   40.772  1    60.5   ? 163 VAL C CG2 1 
ATOM   5862 N  N   . VAL C 1 168 ? -47.173 11.48   40.459  1    61.09  ? 164 VAL C N   1 
ATOM   5863 C  CA  . VAL C 1 168 ? -47.542 12.78   39.916  1    59.34  ? 164 VAL C CA  1 
ATOM   5864 C  C   . VAL C 1 168 ? -47.296 13.838  40.993  1    56.22  ? 164 VAL C C   1 
ATOM   5865 O  O   . VAL C 1 168 ? -47.723 13.708  42.144  1    52.72  ? 164 VAL C O   1 
ATOM   5866 C  CB  . VAL C 1 168 ? -48.97  12.876  39.316  1    57.58  ? 164 VAL C CB  1 
ATOM   5867 C  CG1 . VAL C 1 168 ? -49.112 14.052  38.36   1    49.94  ? 164 VAL C CG1 1 
ATOM   5868 C  CG2 . VAL C 1 168 ? -49.395 11.606  38.573  1    57.06  ? 164 VAL C CG2 1 
ATOM   5869 N  N   . THR C 1 169 ? -46.591 14.899  40.589  1    56.5   ? 165 THR C N   1 
ATOM   5870 C  CA  . THR C 1 169 ? -46.407 16.094  41.409  1    60.82  ? 165 THR C CA  1 
ATOM   5871 C  C   . THR C 1 169 ? -47.788 16.688  41.765  1    60.94  ? 165 THR C C   1 
ATOM   5872 O  O   . THR C 1 169 ? -48.731 16.601  40.966  1    59.31  ? 165 THR C O   1 
ATOM   5873 C  CB  . THR C 1 169 ? -45.478 17.014  40.61   1    54.84  ? 165 THR C CB  1 
ATOM   5874 O  OG1 . THR C 1 169 ? -44.282 16.244  40.461  1    59.03  ? 165 THR C OG1 1 
ATOM   5875 C  CG2 . THR C 1 169 ? -45.194 18.332  41.293  1    49.68  ? 165 THR C CG2 1 
ATOM   5876 N  N   . LEU C 1 170 ? -47.921 17.276  42.963  1    54.8   ? 166 LEU C N   1 
ATOM   5877 C  CA  . LEU C 1 170 ? -49.235 17.498  43.552  1    54.83  ? 166 LEU C CA  1 
ATOM   5878 C  C   . LEU C 1 170 ? -50.19  18.188  42.58   1    55.4   ? 166 LEU C C   1 
ATOM   5879 O  O   . LEU C 1 170 ? -51.316 17.731  42.367  1    60.44  ? 166 LEU C O   1 
ATOM   5880 C  CB  . LEU C 1 170 ? -49.161 18.265  44.869  1    51.84  ? 166 LEU C CB  1 
ATOM   5881 C  CG  . LEU C 1 170 ? -50.511 18.595  45.534  1    52.39  ? 166 LEU C CG  1 
ATOM   5882 C  CD1 . LEU C 1 170 ? -51.3   17.369  45.971  1    50.62  ? 166 LEU C CD1 1 
ATOM   5883 C  CD2 . LEU C 1 170 ? -50.327 19.518  46.729  1    49.62  ? 166 LEU C CD2 1 
ATOM   5884 N  N   . TRP C 1 171 ? -49.731 19.315  42.035  1    52.73  ? 167 TRP C N   1 
ATOM   5885 C  CA  . TRP C 1 171 ? -50.516 20.205  41.201  1    51.36  ? 167 TRP C CA  1 
ATOM   5886 C  C   . TRP C 1 171 ? -51.091 19.499  39.975  1    50.92  ? 167 TRP C C   1 
ATOM   5887 O  O   . TRP C 1 171 ? -52.101 19.94   39.428  1    55.6   ? 167 TRP C O   1 
ATOM   5888 C  CB  . TRP C 1 171 ? -49.643 21.388  40.774  1    50.41  ? 167 TRP C CB  1 
ATOM   5889 C  CG  . TRP C 1 171 ? -49.153 22.264  41.893  1    51.13  ? 167 TRP C CG  1 
ATOM   5890 C  CD1 . TRP C 1 171 ? -49.407 22.175  43.236  1    51.99  ? 167 TRP C CD1 1 
ATOM   5891 C  CD2 . TRP C 1 171 ? -48.326 23.428  41.728  1    49.7   ? 167 TRP C CD2 1 
ATOM   5892 N  NE1 . TRP C 1 171 ? -48.785 23.196  43.916  1    50.68  ? 167 TRP C NE1 1 
ATOM   5893 C  CE2 . TRP C 1 171 ? -48.117 23.979  43.017  1    50.46  ? 167 TRP C CE2 1 
ATOM   5894 C  CE3 . TRP C 1 171 ? -47.759 24.059  40.618  1    50.34  ? 167 TRP C CE3 1 
ATOM   5895 C  CZ2 . TRP C 1 171 ? -47.349 25.121  43.222  1    51.09  ? 167 TRP C CZ2 1 
ATOM   5896 C  CZ3 . TRP C 1 171 ? -47.024 25.214  40.824  1    50.36  ? 167 TRP C CZ3 1 
ATOM   5897 C  CH2 . TRP C 1 171 ? -46.811 25.724  42.102  1    50.19  ? 167 TRP C CH2 1 
ATOM   5898 N  N   . TYR C 1 172 ? -50.462 18.393  39.559  1    48.91  ? 168 TYR C N   1 
ATOM   5899 C  CA  . TYR C 1 172 ? -50.783 17.753  38.292  1    48.75  ? 168 TYR C CA  1 
ATOM   5900 C  C   . TYR C 1 172 ? -51.521 16.437  38.507  1    50.17  ? 168 TYR C C   1 
ATOM   5901 O  O   . TYR C 1 172 ? -51.846 15.745  37.539  1    48.84  ? 168 TYR C O   1 
ATOM   5902 C  CB  . TYR C 1 172 ? -49.503 17.606  37.464  1    48.37  ? 168 TYR C CB  1 
ATOM   5903 C  CG  . TYR C 1 172 ? -48.921 18.973  37.143  1    49.19  ? 168 TYR C CG  1 
ATOM   5904 C  CD1 . TYR C 1 172 ? -49.453 19.756  36.122  1    47.49  ? 168 TYR C CD1 1 
ATOM   5905 C  CD2 . TYR C 1 172 ? -47.921 19.522  37.941  1    48.34  ? 168 TYR C CD2 1 
ATOM   5906 C  CE1 . TYR C 1 172 ? -48.966 21.029  35.861  1    46.77  ? 168 TYR C CE1 1 
ATOM   5907 C  CE2 . TYR C 1 172 ? -47.425 20.788  37.681  1    49.06  ? 168 TYR C CE2 1 
ATOM   5908 C  CZ  . TYR C 1 172 ? -47.931 21.535  36.63   1    48.35  ? 168 TYR C CZ  1 
ATOM   5909 O  OH  . TYR C 1 172 ? -47.397 22.769  36.395  1    50.68  ? 168 TYR C OH  1 
ATOM   5910 N  N   . ARG C 1 173 ? -51.857 16.172  39.78   1    52.78  ? 169 ARG C N   1 
ATOM   5911 C  CA  . ARG C 1 173 ? -52.412 14.901  40.214  1    54.04  ? 169 ARG C CA  1 
ATOM   5912 C  C   . ARG C 1 173 ? -53.927 14.905  40.044  1    55.54  ? 169 ARG C C   1 
ATOM   5913 O  O   . ARG C 1 173 ? -54.603 15.848  40.486  1    57.62  ? 169 ARG C O   1 
ATOM   5914 C  CB  . ARG C 1 173 ? -52.031 14.71   41.686  1    57.86  ? 169 ARG C CB  1 
ATOM   5915 C  CG  . ARG C 1 173 ? -52.141 13.275  42.18   1    57.26  ? 169 ARG C CG  1 
ATOM   5916 C  CD  . ARG C 1 173 ? -51.677 13.139  43.627  1    54.95  ? 169 ARG C CD  1 
ATOM   5917 N  NE  . ARG C 1 173 ? -50.255 13.473  43.757  1    56.92  ? 169 ARG C NE  1 
ATOM   5918 C  CZ  . ARG C 1 173 ? -49.67  13.797  44.903  1    59.51  ? 169 ARG C CZ  1 
ATOM   5919 N  NH1 . ARG C 1 173 ? -50.366 13.788  46.033  1    62.66  ? 169 ARG C NH1 1 
ATOM   5920 N  NH2 . ARG C 1 173 ? -48.398 14.141  44.926  1    57.18  ? 169 ARG C NH2 1 
ATOM   5921 N  N   . ALA C 1 174 ? -54.434 13.822  39.438  1    54.69  ? 170 ALA C N   1 
ATOM   5922 C  CA  . ALA C 1 174 ? -55.848 13.658  39.109  1    55.47  ? 170 ALA C CA  1 
ATOM   5923 C  C   . ALA C 1 174 ? -56.663 13.375  40.365  1    58.86  ? 170 ALA C C   1 
ATOM   5924 O  O   . ALA C 1 174 ? -56.147 12.846  41.35   1    63.65  ? 170 ALA C O   1 
ATOM   5925 C  CB  . ALA C 1 174 ? -56.023 12.55   38.106  1    53.75  ? 170 ALA C CB  1 
ATOM   5926 N  N   . PRO C 1 175 ? -57.951 13.758  40.383  1    59.95  ? 171 PRO C N   1 
ATOM   5927 C  CA  . PRO C 1 175 ? -58.818 13.505  41.539  1    64.38  ? 171 PRO C CA  1 
ATOM   5928 C  C   . PRO C 1 175 ? -58.86  12.069  42.062  1    68.08  ? 171 PRO C C   1 
ATOM   5929 O  O   . PRO C 1 175 ? -58.917 11.864  43.267  1    69.74  ? 171 PRO C O   1 
ATOM   5930 C  CB  . PRO C 1 175 ? -60.198 14.032  41.108  1    65.47  ? 171 PRO C CB  1 
ATOM   5931 C  CG  . PRO C 1 175 ? -60.082 14.26   39.607  1    62.88  ? 171 PRO C CG  1 
ATOM   5932 C  CD  . PRO C 1 175 ? -58.614 14.523  39.32   1    59.9   ? 171 PRO C CD  1 
ATOM   5933 N  N   . GLU C 1 176 ? -58.775 11.079  41.163  1    66.14  ? 172 GLU C N   1 
ATOM   5934 C  CA  . GLU C 1 176 ? -58.887 9.688   41.57   1    67.11  ? 172 GLU C CA  1 
ATOM   5935 C  C   . GLU C 1 176 ? -57.696 9.257   42.434  1    70.56  ? 172 GLU C C   1 
ATOM   5936 O  O   . GLU C 1 176 ? -57.84  8.344   43.259  1    67.24  ? 172 GLU C O   1 
ATOM   5937 C  CB  . GLU C 1 176 ? -59.067 8.759   40.366  1    68.19  ? 172 GLU C CB  1 
ATOM   5938 C  CG  . GLU C 1 176 ? -58.011 8.931   39.274  1    65     ? 172 GLU C CG  1 
ATOM   5939 C  CD  . GLU C 1 176 ? -58.403 9.869   38.145  1    65.78  ? 172 GLU C CD  1 
ATOM   5940 O  OE1 . GLU C 1 176 ? -58.056 9.524   36.977  1    63.83  ? 172 GLU C OE1 1 
ATOM   5941 O  OE2 . GLU C 1 176 ? -59.071 10.917  38.418  1    62.06  ? 172 GLU C OE2 1 
ATOM   5942 N  N   . ILE C 1 177 ? -56.518 9.871   42.196  1    67.51  ? 173 ILE C N   1 
ATOM   5943 C  CA  . ILE C 1 177 ? -55.313 9.579   42.968  1    61.92  ? 173 ILE C CA  1 
ATOM   5944 C  C   . ILE C 1 177 ? -55.384 10.289  44.319  1    63.52  ? 173 ILE C C   1 
ATOM   5945 O  O   . ILE C 1 177 ? -54.948 9.751   45.336  1    65.68  ? 173 ILE C O   1 
ATOM   5946 C  CB  . ILE C 1 177 ? -54.029 9.985   42.227  1    56.96  ? 173 ILE C CB  1 
ATOM   5947 C  CG1 . ILE C 1 177 ? -53.875 9.258   40.899  1    55.96  ? 173 ILE C CG1 1 
ATOM   5948 C  CG2 . ILE C 1 177 ? -52.805 9.767   43.12   1    53.91  ? 173 ILE C CG2 1 
ATOM   5949 C  CD1 . ILE C 1 177 ? -52.688 9.74    40.076  1    53.58  ? 173 ILE C CD1 1 
ATOM   5950 N  N   . LEU C 1 178 ? -55.883 11.525  44.305  1    64.02  ? 174 LEU C N   1 
ATOM   5951 C  CA  . LEU C 1 178 ? -56.002 12.322  45.516  1    69.5   ? 174 LEU C CA  1 
ATOM   5952 C  C   . LEU C 1 178 ? -56.878 11.597  46.534  1    73.24  ? 174 LEU C C   1 
ATOM   5953 O  O   . LEU C 1 178 ? -56.521 11.532  47.709  1    72.02  ? 174 LEU C O   1 
ATOM   5954 C  CB  . LEU C 1 178 ? -56.562 13.702  45.178  1    68.81  ? 174 LEU C CB  1 
ATOM   5955 C  CG  . LEU C 1 178 ? -55.563 14.673  44.543  1    67.42  ? 174 LEU C CG  1 
ATOM   5956 C  CD1 . LEU C 1 178 ? -56.284 15.849  43.897  1    68.34  ? 174 LEU C CD1 1 
ATOM   5957 C  CD2 . LEU C 1 178 ? -54.512 15.11   45.574  1    61.33  ? 174 LEU C CD2 1 
ATOM   5958 N  N   . LEU C 1 179 ? -57.997 11.04   46.046  1    74.79  ? 175 LEU C N   1 
ATOM   5959 C  CA  . LEU C 1 179 ? -59.003 10.37   46.859  1    73.19  ? 175 LEU C CA  1 
ATOM   5960 C  C   . LEU C 1 179 ? -58.621 8.917   47.143  1    74.49  ? 175 LEU C C   1 
ATOM   5961 O  O   . LEU C 1 179 ? -59.448 8.183   47.675  1    77.83  ? 175 LEU C O   1 
ATOM   5962 C  CB  . LEU C 1 179 ? -60.349 10.466  46.144  1    68.39  ? 175 LEU C CB  1 
ATOM   5963 C  CG  . LEU C 1 179 ? -60.89  11.886  45.965  1    69.79  ? 175 LEU C CG  1 
ATOM   5964 C  CD1 . LEU C 1 179 ? -62.113 11.896  45.052  1    69.64  ? 175 LEU C CD1 1 
ATOM   5965 C  CD2 . LEU C 1 179 ? -61.208 12.519  47.324  1    72.19  ? 175 LEU C CD2 1 
ATOM   5966 N  N   . GLY C 1 180 ? -57.396 8.503   46.763  1    71.47  ? 176 GLY C N   1 
ATOM   5967 C  CA  . GLY C 1 180 ? -56.881 7.162   47.024  1    65.65  ? 176 GLY C CA  1 
ATOM   5968 C  C   . GLY C 1 180 ? -57.805 6.054   46.52   1    66.74  ? 176 GLY C C   1 
ATOM   5969 O  O   . GLY C 1 180 ? -58.049 5.087   47.233  1    63.91  ? 176 GLY C O   1 
ATOM   5970 N  N   . CYS C 1 181 ? -58.311 6.205   45.288  1    70.47  ? 177 CYS C N   1 
ATOM   5971 C  CA  . CYS C 1 181 ? -59.061 5.15    44.628  1    71.2   ? 177 CYS C CA  1 
ATOM   5972 C  C   . CYS C 1 181 ? -58.18  3.923   44.452  1    70.27  ? 177 CYS C C   1 
ATOM   5973 O  O   . CYS C 1 181 ? -56.976 4.05    44.281  1    70.25  ? 177 CYS C O   1 
ATOM   5974 C  CB  . CYS C 1 181 ? -59.47  5.558   43.226  1    72.51  ? 177 CYS C CB  1 
ATOM   5975 S  SG  . CYS C 1 181 ? -60.816 6.766   43.246  1    81.62  ? 177 CYS C SG  1 
ATOM   5976 N  N   . LYS C 1 182 ? -58.806 2.745   44.478  1    71.62  ? 178 LYS C N   1 
ATOM   5977 C  CA  . LYS C 1 182 ? -58.085 1.494   44.369  1    69.5   ? 178 LYS C CA  1 
ATOM   5978 C  C   . LYS C 1 182 ? -57.346 1.452   43.034  1    68.78  ? 178 LYS C C   1 
ATOM   5979 O  O   . LYS C 1 182 ? -56.187 1.042   42.98   1    73.36  ? 178 LYS C O   1 
ATOM   5980 C  CB  . LYS C 1 182 ? -59.033 0.304   44.53   1    72     ? 178 LYS C CB  1 
ATOM   5981 C  CG  . LYS C 1 182 ? -58.344 -0.985  44.933  1    75.13  ? 178 LYS C CG  1 
ATOM   5982 C  CD  . LYS C 1 182 ? -59.314 -2.157  44.924  1    80.4   ? 178 LYS C CD  1 
ATOM   5983 C  CE  . LYS C 1 182 ? -58.672 -3.461  45.27   1    86.52  ? 178 LYS C CE  1 
ATOM   5984 N  NZ  . LYS C 1 182 ? -59.632 -4.535  44.979  1    95.09  ? 178 LYS C NZ  1 
ATOM   5985 N  N   . TYR C 1 183 ? -58.021 1.9     41.974  1    65     ? 179 TYR C N   1 
ATOM   5986 C  CA  . TYR C 1 183 ? -57.486 1.79    40.632  1    62.6   ? 179 TYR C CA  1 
ATOM   5987 C  C   . TYR C 1 183 ? -57.407 3.169   39.985  1    64.66  ? 179 TYR C C   1 
ATOM   5988 O  O   . TYR C 1 183 ? -58.197 4.062   40.29   1    67.48  ? 179 TYR C O   1 
ATOM   5989 C  CB  . TYR C 1 183 ? -58.358 0.864   39.787  1    63.14  ? 179 TYR C CB  1 
ATOM   5990 C  CG  . TYR C 1 183 ? -58.518 -0.561  40.298  1    67.18  ? 179 TYR C CG  1 
ATOM   5991 C  CD1 . TYR C 1 183 ? -57.407 -1.362  40.584  1    67.63  ? 179 TYR C CD1 1 
ATOM   5992 C  CD2 . TYR C 1 183 ? -59.783 -1.113  40.489  1    68.74  ? 179 TYR C CD2 1 
ATOM   5993 C  CE1 . TYR C 1 183 ? -57.542 -2.664  41.045  1    67.44  ? 179 TYR C CE1 1 
ATOM   5994 C  CE2 . TYR C 1 183 ? -59.931 -2.41   40.961  1    71.24  ? 179 TYR C CE2 1 
ATOM   5995 C  CZ  . TYR C 1 183 ? -58.814 -3.186  41.238  1    72.74  ? 179 TYR C CZ  1 
ATOM   5996 O  OH  . TYR C 1 183 ? -58.982 -4.465  41.695  1    77.49  ? 179 TYR C OH  1 
ATOM   5997 N  N   . TYR C 1 184 ? -56.402 3.328   39.116  1    63.37  ? 180 TYR C N   1 
ATOM   5998 C  CA  . TYR C 1 184 ? -56.232 4.482   38.245  1    60.02  ? 180 TYR C CA  1 
ATOM   5999 C  C   . TYR C 1 184 ? -55.597 3.989   36.938  1    57.42  ? 180 TYR C C   1 
ATOM   6000 O  O   . TYR C 1 184 ? -54.992 2.912   36.893  1    55.14  ? 180 TYR C O   1 
ATOM   6001 C  CB  . TYR C 1 184 ? -55.469 5.603   38.963  1    56.28  ? 180 TYR C CB  1 
ATOM   6002 C  CG  . TYR C 1 184 ? -53.988 5.368   39.218  1    54.41  ? 180 TYR C CG  1 
ATOM   6003 C  CD1 . TYR C 1 184 ? -53.074 5.367   38.166  1    51.51  ? 180 TYR C CD1 1 
ATOM   6004 C  CD2 . TYR C 1 184 ? -53.499 5.174   40.502  1    52.19  ? 180 TYR C CD2 1 
ATOM   6005 C  CE1 . TYR C 1 184 ? -51.73  5.156   38.4    1    50.26  ? 180 TYR C CE1 1 
ATOM   6006 C  CE2 . TYR C 1 184 ? -52.153 4.965   40.743  1    49.12  ? 180 TYR C CE2 1 
ATOM   6007 C  CZ  . TYR C 1 184 ? -51.255 4.966   39.69   1    50.63  ? 180 TYR C CZ  1 
ATOM   6008 O  OH  . TYR C 1 184 ? -49.897 4.769   39.909  1    51.38  ? 180 TYR C OH  1 
ATOM   6009 N  N   . SER C 1 185 ? -55.777 4.763   35.864  1    55.83  ? 181 SER C N   1 
ATOM   6010 C  CA  . SER C 1 185 ? -55.397 4.278   34.551  1    55.09  ? 181 SER C CA  1 
ATOM   6011 C  C   . SER C 1 185 ? -54.826 5.429   33.733  1    53.03  ? 181 SER C C   1 
ATOM   6012 O  O   . SER C 1 185 ? -54.254 6.353   34.316  1    53.53  ? 181 SER C O   1 
ATOM   6013 C  CB  . SER C 1 185 ? -56.59  3.626   33.878  1    59.29  ? 181 SER C CB  1 
ATOM   6014 O  OG  . SER C 1 185 ? -56.21  2.644   32.924  1    60.02  ? 181 SER C OG  1 
ATOM   6015 N  N   . THR C 1 186 ? -54.998 5.351   32.402  1    52.67  ? 182 THR C N   1 
ATOM   6016 C  CA  . THR C 1 186 ? -54.423 6.27    31.428  1    51.28  ? 182 THR C CA  1 
ATOM   6017 C  C   . THR C 1 186 ? -55.061 7.649   31.589  1    55.69  ? 182 THR C C   1 
ATOM   6018 O  O   . THR C 1 186 ? -54.545 8.648   31.068  1    60.4   ? 182 THR C O   1 
ATOM   6019 C  CB  . THR C 1 186 ? -54.637 5.704   30.019  1    51.33  ? 182 THR C CB  1 
ATOM   6020 O  OG1 . THR C 1 186 ? -56.003 5.304   29.961  1    57.32  ? 182 THR C OG1 1 
ATOM   6021 C  CG2 . THR C 1 186 ? -53.806 4.47    29.698  1    47.27  ? 182 THR C CG2 1 
ATOM   6022 N  N   . ALA C 1 187 ? -56.189 7.7     32.319  1    54.85  ? 183 ALA C N   1 
ATOM   6023 C  CA  . ALA C 1 187 ? -56.864 8.949   32.624  1    56.6   ? 183 ALA C CA  1 
ATOM   6024 C  C   . ALA C 1 187 ? -55.963 9.939   33.375  1    58.14  ? 183 ALA C C   1 
ATOM   6025 O  O   . ALA C 1 187 ? -56.054 11.137  33.117  1    63.14  ? 183 ALA C O   1 
ATOM   6026 C  CB  . ALA C 1 187 ? -58.136 8.656   33.373  1    57.24  ? 183 ALA C CB  1 
ATOM   6027 N  N   . VAL C 1 188 ? -55.103 9.452   34.295  1    55.5   ? 184 VAL C N   1 
ATOM   6028 C  CA  . VAL C 1 188 ? -54.308 10.323  35.14   1    50.6   ? 184 VAL C CA  1 
ATOM   6029 C  C   . VAL C 1 188 ? -53.387 11.18   34.273  1    50.88  ? 184 VAL C C   1 
ATOM   6030 O  O   . VAL C 1 188 ? -53.111 12.331  34.605  1    54.94  ? 184 VAL C O   1 
ATOM   6031 C  CB  . VAL C 1 188 ? -53.55  9.617   36.276  1    48.85  ? 184 VAL C CB  1 
ATOM   6032 C  CG1 . VAL C 1 188 ? -54.455 8.681   37.076  1    49.54  ? 184 VAL C CG1 1 
ATOM   6033 C  CG2 . VAL C 1 188 ? -52.325 8.879   35.781  1    49.22  ? 184 VAL C CG2 1 
ATOM   6034 N  N   . ASP C 1 189 ? -52.922 10.633  33.15   1    48.79  ? 185 ASP C N   1 
ATOM   6035 C  CA  . ASP C 1 189 ? -51.956 11.345  32.328  1    49.6   ? 185 ASP C CA  1 
ATOM   6036 C  C   . ASP C 1 189 ? -52.649 12.446  31.532  1    48.24  ? 185 ASP C C   1 
ATOM   6037 O  O   . ASP C 1 189 ? -52.059 13.484  31.238  1    48.47  ? 185 ASP C O   1 
ATOM   6038 C  CB  . ASP C 1 189 ? -51.19  10.395  31.424  1    50.97  ? 185 ASP C CB  1 
ATOM   6039 C  CG  . ASP C 1 189 ? -50.129 9.556   32.126  1    53.11  ? 185 ASP C CG  1 
ATOM   6040 O  OD1 . ASP C 1 189 ? -49.615 9.995   33.194  1    53.46  ? 185 ASP C OD1 1 
ATOM   6041 O  OD2 . ASP C 1 189 ? -49.821 8.468   31.593  1    50.16  ? 185 ASP C OD2 1 
ATOM   6042 N  N   . ILE C 1 190 ? -53.907 12.204  31.174  1    48.26  ? 186 ILE C N   1 
ATOM   6043 C  CA  . ILE C 1 190 ? -54.706 13.191  30.471  1    49.37  ? 186 ILE C CA  1 
ATOM   6044 C  C   . ILE C 1 190 ? -55.031 14.352  31.418  1    49.85  ? 186 ILE C C   1 
ATOM   6045 O  O   . ILE C 1 190 ? -54.971 15.518  31.036  1    47.74  ? 186 ILE C O   1 
ATOM   6046 C  CB  . ILE C 1 190 ? -55.963 12.516  29.901  1    54.53  ? 186 ILE C CB  1 
ATOM   6047 C  CG1 . ILE C 1 190 ? -55.635 11.607  28.692  1    50.78  ? 186 ILE C CG1 1 
ATOM   6048 C  CG2 . ILE C 1 190 ? -57.028 13.56   29.553  1    60.22  ? 186 ILE C CG2 1 
ATOM   6049 C  CD1 . ILE C 1 190 ? -55.191 12.362  27.448  1    49.86  ? 186 ILE C CD1 1 
ATOM   6050 N  N   . TRP C 1 191 ? -55.329 14.036  32.682  1    49.37  ? 187 TRP C N   1 
ATOM   6051 C  CA  . TRP C 1 191 ? -55.587 15.077  33.649  1    49.37  ? 187 TRP C CA  1 
ATOM   6052 C  C   . TRP C 1 191 ? -54.392 16.032  33.703  1    49.56  ? 187 TRP C C   1 
ATOM   6053 O  O   . TRP C 1 191 ? -54.535 17.26   33.65   1    49.83  ? 187 TRP C O   1 
ATOM   6054 C  CB  . TRP C 1 191 ? -55.889 14.462  35.02   1    49.67  ? 187 TRP C CB  1 
ATOM   6055 C  CG  . TRP C 1 191 ? -56.127 15.524  36.064  1    51.69  ? 187 TRP C CG  1 
ATOM   6056 C  CD1 . TRP C 1 191 ? -55.171 16.115  36.829  1    49.24  ? 187 TRP C CD1 1 
ATOM   6057 C  CD2 . TRP C 1 191 ? -57.374 16.178  36.387  1    53.15  ? 187 TRP C CD2 1 
ATOM   6058 N  NE1 . TRP C 1 191 ? -55.741 17.061  37.628  1    52.52  ? 187 TRP C NE1 1 
ATOM   6059 C  CE2 . TRP C 1 191 ? -57.084 17.124  37.384  1    54.29  ? 187 TRP C CE2 1 
ATOM   6060 C  CE3 . TRP C 1 191 ? -58.704 16.038  35.963  1    56.24  ? 187 TRP C CE3 1 
ATOM   6061 C  CZ2 . TRP C 1 191 ? -58.073 17.928  37.959  1    57.87  ? 187 TRP C CZ2 1 
ATOM   6062 C  CZ3 . TRP C 1 191 ? -59.675 16.844  36.514  1    57.12  ? 187 TRP C CZ3 1 
ATOM   6063 C  CH2 . TRP C 1 191 ? -59.362 17.781  37.497  1    59.24  ? 187 TRP C CH2 1 
ATOM   6064 N  N   . SER C 1 192 ? -53.198 15.454  33.805  1    49.86  ? 188 SER C N   1 
ATOM   6065 C  CA  . SER C 1 192 ? -51.965 16.23   33.852  1    51.86  ? 188 SER C CA  1 
ATOM   6066 C  C   . SER C 1 192 ? -51.83  17.115  32.605  1    53.93  ? 188 SER C C   1 
ATOM   6067 O  O   . SER C 1 192 ? -51.587 18.315  32.725  1    53.09  ? 188 SER C O   1 
ATOM   6068 C  CB  . SER C 1 192 ? -50.752 15.324  34.048  1    51.09  ? 188 SER C CB  1 
ATOM   6069 O  OG  . SER C 1 192 ? -50.908 14.541  35.224  1    51.48  ? 188 SER C OG  1 
ATOM   6070 N  N   . LEU C 1 193 ? -52.019 16.528  31.408  1    54.06  ? 189 LEU C N   1 
ATOM   6071 C  CA  . LEU C 1 193 ? -51.956 17.299  30.178  1    52.6   ? 189 LEU C CA  1 
ATOM   6072 C  C   . LEU C 1 193 ? -52.999 18.411  30.206  1    52.43  ? 189 LEU C C   1 
ATOM   6073 O  O   . LEU C 1 193 ? -52.752 19.509  29.729  1    55.1   ? 189 LEU C O   1 
ATOM   6074 C  CB  . LEU C 1 193 ? -52.126 16.416  28.947  1    53.16  ? 189 LEU C CB  1 
ATOM   6075 C  CG  . LEU C 1 193 ? -50.923 15.555  28.552  1    55.3   ? 189 LEU C CG  1 
ATOM   6076 C  CD1 . LEU C 1 193 ? -51.111 15.01   27.138  1    55.22  ? 189 LEU C CD1 1 
ATOM   6077 C  CD2 . LEU C 1 193 ? -49.602 16.296  28.675  1    53.95  ? 189 LEU C CD2 1 
ATOM   6078 N  N   . GLY C 1 194 ? -54.177 18.128  30.754  1    52.74  ? 190 GLY C N   1 
ATOM   6079 C  CA  . GLY C 1 194 ? -55.207 19.149  30.83   1    53.5   ? 190 GLY C CA  1 
ATOM   6080 C  C   . GLY C 1 194 ? -54.736 20.348  31.654  1    52.59  ? 190 GLY C C   1 
ATOM   6081 O  O   . GLY C 1 194 ? -54.848 21.492  31.208  1    54.53  ? 190 GLY C O   1 
ATOM   6082 N  N   . CYS C 1 195 ? -54.17  20.073  32.835  1    50.6   ? 191 CYS C N   1 
ATOM   6083 C  CA  . CYS C 1 195 ? -53.607 21.12   33.678  1    50.9   ? 191 CYS C CA  1 
ATOM   6084 C  C   . CYS C 1 195 ? -52.494 21.878  32.952  1    49.33  ? 191 CYS C C   1 
ATOM   6085 O  O   . CYS C 1 195 ? -52.331 23.082  33.156  1    49.76  ? 191 CYS C O   1 
ATOM   6086 C  CB  . CYS C 1 195 ? -53.052 20.559  34.982  1    50.43  ? 191 CYS C CB  1 
ATOM   6087 S  SG  . CYS C 1 195 ? -54.272 19.654  35.971  1    54.59  ? 191 CYS C SG  1 
ATOM   6088 N  N   . ILE C 1 196 ? -51.744 21.175  32.099  1    47.74  ? 192 ILE C N   1 
ATOM   6089 C  CA  . ILE C 1 196 ? -50.649 21.778  31.352  1    49.84  ? 192 ILE C CA  1 
ATOM   6090 C  C   . ILE C 1 196 ? -51.18  22.614  30.192  1    49.27  ? 192 ILE C C   1 
ATOM   6091 O  O   . ILE C 1 196 ? -50.626 23.659  29.886  1    53.45  ? 192 ILE C O   1 
ATOM   6092 C  CB  . ILE C 1 196 ? -49.627 20.711  30.899  1    51.56  ? 192 ILE C CB  1 
ATOM   6093 C  CG1 . ILE C 1 196 ? -48.839 20.145  32.108  1    48.14  ? 192 ILE C CG1 1 
ATOM   6094 C  CG2 . ILE C 1 196 ? -48.686 21.261  29.824  1    48.84  ? 192 ILE C CG2 1 
ATOM   6095 C  CD1 . ILE C 1 196 ? -48.183 18.809  31.833  1    45.24  ? 192 ILE C CD1 1 
ATOM   6096 N  N   . PHE C 1 197 ? -52.241 22.158  29.528  1    48.86  ? 193 PHE C N   1 
ATOM   6097 C  CA  . PHE C 1 197 ? -52.891 22.989  28.528  1    51.24  ? 193 PHE C CA  1 
ATOM   6098 C  C   . PHE C 1 197 ? -53.216 24.348  29.147  1    51.89  ? 193 PHE C C   1 
ATOM   6099 O  O   . PHE C 1 197 ? -52.77  25.383  28.651  1    51.37  ? 193 PHE C O   1 
ATOM   6100 C  CB  . PHE C 1 197 ? -54.118 22.241  27.999  1    53.12  ? 193 PHE C CB  1 
ATOM   6101 C  CG  . PHE C 1 197 ? -54.872 22.936  26.882  1    54.95  ? 193 PHE C CG  1 
ATOM   6102 C  CD1 . PHE C 1 197 ? -54.285 23.968  26.153  1    55.51  ? 193 PHE C CD1 1 
ATOM   6103 C  CD2 . PHE C 1 197 ? -56.157 22.518  26.536  1    56.33  ? 193 PHE C CD2 1 
ATOM   6104 C  CE1 . PHE C 1 197 ? -54.989 24.59   25.123  1    58.79  ? 193 PHE C CE1 1 
ATOM   6105 C  CE2 . PHE C 1 197 ? -56.846 23.137  25.501  1    57.26  ? 193 PHE C CE2 1 
ATOM   6106 C  CZ  . PHE C 1 197 ? -56.268 24.174  24.794  1    58.87  ? 193 PHE C CZ  1 
ATOM   6107 N  N   . ALA C 1 198 ? -53.971 24.323  30.257  1    52.11  ? 194 ALA C N   1 
ATOM   6108 C  CA  . ALA C 1 198 ? -54.406 25.535  30.934  1    53.29  ? 194 ALA C CA  1 
ATOM   6109 C  C   . ALA C 1 198 ? -53.231 26.458  31.203  1    53.61  ? 194 ALA C C   1 
ATOM   6110 O  O   . ALA C 1 198 ? -53.33  27.669  30.984  1    57.57  ? 194 ALA C O   1 
ATOM   6111 C  CB  . ALA C 1 198 ? -55.112 25.177  32.206  1    52.95  ? 194 ALA C CB  1 
ATOM   6112 N  N   . GLU C 1 199 ? -52.133 25.867  31.689  1    53.96  ? 195 GLU C N   1 
ATOM   6113 C  CA  . GLU C 1 199 ? -50.964 26.61   32.158  1    56.97  ? 195 GLU C CA  1 
ATOM   6114 C  C   . GLU C 1 199 ? -50.223 27.238  30.975  1    57.24  ? 195 GLU C C   1 
ATOM   6115 O  O   . GLU C 1 199 ? -49.606 28.295  31.102  1    58.03  ? 195 GLU C O   1 
ATOM   6116 C  CB  . GLU C 1 199 ? -50.094 25.69   33.016  1    54.89  ? 195 GLU C CB  1 
ATOM   6117 C  CG  . GLU C 1 199 ? -48.958 26.375  33.772  1    56.57  ? 195 GLU C CG  1 
ATOM   6118 C  CD  . GLU C 1 199 ? -48.176 25.45   34.706  1    56.09  ? 195 GLU C CD  1 
ATOM   6119 O  OE1 . GLU C 1 199 ? -48.661 24.342  35.008  1    53.28  ? 195 GLU C OE1 1 
ATOM   6120 O  OE2 . GLU C 1 199 ? -47.063 25.828  35.133  1    58.44  ? 195 GLU C OE2 1 
ATOM   6121 N  N   . MET C 1 200 ? -50.302 26.598  29.806  1    57.95  ? 196 MET C N   1 
ATOM   6122 C  CA  . MET C 1 200 ? -49.705 27.151  28.601  1    58.95  ? 196 MET C CA  1 
ATOM   6123 C  C   . MET C 1 200 ? -50.426 28.431  28.179  1    60.62  ? 196 MET C C   1 
ATOM   6124 O  O   . MET C 1 200 ? -49.807 29.397  27.754  1    66.61  ? 196 MET C O   1 
ATOM   6125 C  CB  . MET C 1 200 ? -49.732 26.122  27.472  1    57.02  ? 196 MET C CB  1 
ATOM   6126 C  CG  . MET C 1 200 ? -48.616 25.124  27.565  1    54.13  ? 196 MET C CG  1 
ATOM   6127 S  SD  . MET C 1 200 ? -48.335 24.309  25.979  1    54.95  ? 196 MET C SD  1 
ATOM   6128 C  CE  . MET C 1 200 ? -49.683 23.125  25.893  1    50.34  ? 196 MET C CE  1 
ATOM   6129 N  N   . VAL C 1 201 ? -51.745 28.443  28.337  1    61.53  ? 197 VAL C N   1 
ATOM   6130 C  CA  . VAL C 1 201 ? -52.547 29.616  28.03   1    66.2   ? 197 VAL C CA  1 
ATOM   6131 C  C   . VAL C 1 201 ? -52.297 30.767  29.02   1    70.82  ? 197 VAL C C   1 
ATOM   6132 O  O   . VAL C 1 201 ? -52.185 31.916  28.593  1    68.95  ? 197 VAL C O   1 
ATOM   6133 C  CB  . VAL C 1 201 ? -54.037 29.223  28.027  1    65.94  ? 197 VAL C CB  1 
ATOM   6134 C  CG1 . VAL C 1 201 ? -54.918 30.459  28.021  1    67.32  ? 197 VAL C CG1 1 
ATOM   6135 C  CG2 . VAL C 1 201 ? -54.392 28.273  26.887  1    62.38  ? 197 VAL C CG2 1 
ATOM   6136 N  N   . THR C 1 202 ? -52.246 30.474  30.338  1    69.08  ? 198 THR C N   1 
ATOM   6137 C  CA  . THR C 1 202 ? -52.246 31.524  31.353  1    70.05  ? 198 THR C CA  1 
ATOM   6138 C  C   . THR C 1 202 ? -50.845 31.781  31.915  1    67.51  ? 198 THR C C   1 
ATOM   6139 O  O   . THR C 1 202 ? -50.634 32.769  32.604  1    66.3   ? 198 THR C O   1 
ATOM   6140 C  CB  . THR C 1 202 ? -53.238 31.211  32.48   1    69.2   ? 198 THR C CB  1 
ATOM   6141 O  OG1 . THR C 1 202 ? -52.715 30.128  33.249  1    70.56  ? 198 THR C OG1 1 
ATOM   6142 C  CG2 . THR C 1 202 ? -54.614 30.837  31.959  1    67.95  ? 198 THR C CG2 1 
ATOM   6143 N  N   . ARG C 1 203 ? -49.907 30.873  31.675  1    71.44  ? 199 ARG C N   1 
ATOM   6144 C  CA  . ARG C 1 203 ? -48.52  30.982  32.223  1    80.09  ? 199 ARG C CA  1 
ATOM   6145 C  C   . ARG C 1 203 ? -48.527 30.856  33.757  1    75.02  ? 199 ARG C C   1 
ATOM   6146 O  O   . ARG C 1 203 ? -47.492 31.183  34.361  1    77.93  ? 199 ARG C O   1 
ATOM   6147 C  CB  . ARG C 1 203 ? -47.742 32.197  31.701  1    86.91  ? 199 ARG C CB  1 
ATOM   6148 C  CG  . ARG C 1 203 ? -46.956 31.882  30.438  1    79.97  ? 199 ARG C CG  1 
ATOM   6149 C  CD  . ARG C 1 203 ? -47.64  32.502  29.239  1    83.58  ? 199 ARG C CD  1 
ATOM   6150 N  NE  . ARG C 1 203 ? -47.961 33.904  29.522  1    86.36  ? 199 ARG C NE  1 
ATOM   6151 C  CZ  . ARG C 1 203 ? -49.177 34.423  29.465  1    84.76  ? 199 ARG C CZ  1 
ATOM   6152 N  NH1 . ARG C 1 203 ? -49.385 35.659  29.874  1    85.4   ? 199 ARG C NH1 1 
ATOM   6153 N  NH2 . ARG C 1 203 ? -50.179 33.705  28.995  1    84.77  ? 199 ARG C NH2 1 
ATOM   6154 N  N   . ARG C 1 204 ? -49.63  30.419  34.361  1    69.64  ? 200 ARG C N   1 
ATOM   6155 C  CA  . ARG C 1 204 ? -49.659 30.117  35.783  1    70.33  ? 200 ARG C CA  1 
ATOM   6156 C  C   . ARG C 1 204 ? -50.394 28.794  35.945  1    66.88  ? 200 ARG C C   1 
ATOM   6157 O  O   . ARG C 1 204 ? -51.271 28.486  35.139  1    70.37  ? 200 ARG C O   1 
ATOM   6158 C  CB  . ARG C 1 204 ? -50.266 31.259  36.602  1    73.41  ? 200 ARG C CB  1 
ATOM   6159 C  CG  . ARG C 1 204 ? -51.277 32.094  35.825  1    81.23  ? 200 ARG C CG  1 
ATOM   6160 C  CD  . ARG C 1 204 ? -52.049 32.899  36.875  1    88.3   ? 200 ARG C CD  1 
ATOM   6161 N  NE  . ARG C 1 204 ? -52.556 34.142  36.283  1    104.8  ? 200 ARG C NE  1 
ATOM   6162 C  CZ  . ARG C 1 204 ? -51.809 35.243  36.191  1    109.31 ? 200 ARG C CZ  1 
ATOM   6163 N  NH1 . ARG C 1 204 ? -52.185 36.29   35.462  1    100.63 ? 200 ARG C NH1 1 
ATOM   6164 N  NH2 . ARG C 1 204 ? -50.647 35.263  36.816  1    117.17 ? 200 ARG C NH2 1 
ATOM   6165 N  N   . ALA C 1 205 ? -49.981 28.017  36.953  1    59     ? 201 ALA C N   1 
ATOM   6166 C  CA  . ALA C 1 205 ? -50.525 26.703  37.244  1    55.87  ? 201 ALA C CA  1 
ATOM   6167 C  C   . ALA C 1 205 ? -52.025 26.819  37.442  1    58.83  ? 201 ALA C C   1 
ATOM   6168 O  O   . ALA C 1 205 ? -52.491 27.827  37.964  1    63.69  ? 201 ALA C O   1 
ATOM   6169 C  CB  . ALA C 1 205 ? -49.864 26.135  38.48   1    55.68  ? 201 ALA C CB  1 
ATOM   6170 N  N   . LEU C 1 206 ? -52.76  25.774  37.041  1    58.02  ? 202 LEU C N   1 
ATOM   6171 C  CA  . LEU C 1 206 ? -54.214 25.74   37.149  1    55.98  ? 202 LEU C CA  1 
ATOM   6172 C  C   . LEU C 1 206 ? -54.651 25.462  38.584  1    55.18  ? 202 LEU C C   1 
ATOM   6173 O  O   . LEU C 1 206 ? -55.587 26.085  39.054  1    57.36  ? 202 LEU C O   1 
ATOM   6174 C  CB  . LEU C 1 206 ? -54.801 24.695  36.203  1    53.14  ? 202 LEU C CB  1 
ATOM   6175 C  CG  . LEU C 1 206 ? -56.329 24.696  36.125  1    53.9   ? 202 LEU C CG  1 
ATOM   6176 C  CD1 . LEU C 1 206 ? -56.826 26.051  35.642  1    53.7   ? 202 LEU C CD1 1 
ATOM   6177 C  CD2 . LEU C 1 206 ? -56.859 23.598  35.23   1    52.76  ? 202 LEU C CD2 1 
ATOM   6178 N  N   . PHE C 1 207 ? -53.992 24.505  39.249  1    54.3   ? 203 PHE C N   1 
ATOM   6179 C  CA  . PHE C 1 207 ? -54.372 24.065  40.589  1    57.02  ? 203 PHE C CA  1 
ATOM   6180 C  C   . PHE C 1 207 ? -53.148 24.031  41.509  1    57.64  ? 203 PHE C C   1 
ATOM   6181 O  O   . PHE C 1 207 ? -52.598 22.969  41.796  1    59.17  ? 203 PHE C O   1 
ATOM   6182 C  CB  . PHE C 1 207 ? -55.067 22.701  40.493  1    56.08  ? 203 PHE C CB  1 
ATOM   6183 C  CG  . PHE C 1 207 ? -56.339 22.683  39.651  1    57.34  ? 203 PHE C CG  1 
ATOM   6184 C  CD1 . PHE C 1 207 ? -57.352 23.601  39.855  1    58.09  ? 203 PHE C CD1 1 
ATOM   6185 C  CD2 . PHE C 1 207 ? -56.512 21.746  38.647  1    58.43  ? 203 PHE C CD2 1 
ATOM   6186 C  CE1 . PHE C 1 207 ? -58.494 23.573  39.079  1    61.2   ? 203 PHE C CE1 1 
ATOM   6187 C  CE2 . PHE C 1 207 ? -57.662 21.715  37.873  1    59.94  ? 203 PHE C CE2 1 
ATOM   6188 C  CZ  . PHE C 1 207 ? -58.66  22.623  38.1    1    62.36  ? 203 PHE C CZ  1 
ATOM   6189 N  N   . PRO C 1 208 ? -52.641 25.19   41.984  1    58.65  ? 204 PRO C N   1 
ATOM   6190 C  CA  . PRO C 1 208 ? -51.436 25.181  42.806  1    56.87  ? 204 PRO C CA  1 
ATOM   6191 C  C   . PRO C 1 208 ? -51.788 24.987  44.281  1    57.23  ? 204 PRO C C   1 
ATOM   6192 O  O   . PRO C 1 208 ? -51.825 25.942  45.049  1    61.6   ? 204 PRO C O   1 
ATOM   6193 C  CB  . PRO C 1 208 ? -50.857 26.587  42.457  1    55.38  ? 204 PRO C CB  1 
ATOM   6194 C  CG  . PRO C 1 208 ? -52.09  27.481  42.336  1    56.46  ? 204 PRO C CG  1 
ATOM   6195 C  CD  . PRO C 1 208 ? -53.151 26.56   41.74   1    57.84  ? 204 PRO C CD  1 
ATOM   6196 N  N   . GLY C 1 209 ? -52.054 23.741  44.667  1    54.76  ? 205 GLY C N   1 
ATOM   6197 C  CA  . GLY C 1 209 ? -52.399 23.446  46.047  1    56.31  ? 205 GLY C CA  1 
ATOM   6198 C  C   . GLY C 1 209 ? -51.171 23.378  46.953  1    57.4   ? 205 GLY C C   1 
ATOM   6199 O  O   . GLY C 1 209 ? -50.084 23.04   46.482  1    57.14  ? 205 GLY C O   1 
ATOM   6200 N  N   . ASP C 1 210 ? -51.382 23.672  48.248  1    60.57  ? 206 ASP C N   1 
ATOM   6201 C  CA  . ASP C 1 210 ? -50.371 23.636  49.299  1    62.81  ? 206 ASP C CA  1 
ATOM   6202 C  C   . ASP C 1 210 ? -50.441 22.322  50.061  1    63.01  ? 206 ASP C C   1 
ATOM   6203 O  O   . ASP C 1 210 ? -49.603 22.063  50.906  1    64.63  ? 206 ASP C O   1 
ATOM   6204 C  CB  . ASP C 1 210 ? -50.566 24.746  50.316  1    64.81  ? 206 ASP C CB  1 
ATOM   6205 C  CG  . ASP C 1 210 ? -50.598 26.125  49.677  1    71.25  ? 206 ASP C CG  1 
ATOM   6206 O  OD1 . ASP C 1 210 ? -49.831 26.297  48.696  1    70.09  ? 206 ASP C OD1 1 
ATOM   6207 O  OD2 . ASP C 1 210 ? -51.415 26.986  50.125  1    71.57  ? 206 ASP C OD2 1 
ATOM   6208 N  N   . SER C 1 211 ? -51.465 21.521  49.778  1    64.4   ? 207 SER C N   1 
ATOM   6209 C  CA  . SER C 1 211 ? -51.703 20.265  50.47   1    64.99  ? 207 SER C CA  1 
ATOM   6210 C  C   . SER C 1 211 ? -52.709 19.465  49.663  1    64.82  ? 207 SER C C   1 
ATOM   6211 O  O   . SER C 1 211 ? -53.282 19.976  48.708  1    64.6   ? 207 SER C O   1 
ATOM   6212 C  CB  . SER C 1 211 ? -52.202 20.469  51.871  1    64.82  ? 207 SER C CB  1 
ATOM   6213 O  OG  . SER C 1 211 ? -53.53  20.959  51.877  1    65.09  ? 207 SER C OG  1 
ATOM   6214 N  N   . GLU C 1 212 ? -52.911 18.207  50.051  1    70.52  ? 208 GLU C N   1 
ATOM   6215 C  CA  . GLU C 1 212 ? -53.825 17.327  49.338  1    71.09  ? 208 GLU C CA  1 
ATOM   6216 C  C   . GLU C 1 212 ? -55.242 17.887  49.414  1    70.48  ? 208 GLU C C   1 
ATOM   6217 O  O   . GLU C 1 212 ? -55.941 17.941  48.404  1    67.92  ? 208 GLU C O   1 
ATOM   6218 C  CB  . GLU C 1 212 ? -53.679 15.901  49.864  1    73.9   ? 208 GLU C CB  1 
ATOM   6219 C  CG  . GLU C 1 212 ? -52.531 15.18   49.164  1    76.65  ? 208 GLU C CG  1 
ATOM   6220 C  CD  . GLU C 1 212 ? -52.073 13.846  49.716  1    80.1   ? 208 GLU C CD  1 
ATOM   6221 O  OE1 . GLU C 1 212 ? -52.904 13.051  50.222  1    82.26  ? 208 GLU C OE1 1 
ATOM   6222 O  OE2 . GLU C 1 212 ? -50.855 13.595  49.583  1    76.16  ? 208 GLU C OE2 1 
ATOM   6223 N  N   . ILE C 1 213 ? -55.625 18.339  50.618  1    71.06  ? 209 ILE C N   1 
ATOM   6224 C  CA  . ILE C 1 213 ? -56.964 18.836  50.875  1    71.09  ? 209 ILE C CA  1 
ATOM   6225 C  C   . ILE C 1 213 ? -57.188 20.127  50.082  1    69.37  ? 209 ILE C C   1 
ATOM   6226 O  O   . ILE C 1 213 ? -58.26  20.303  49.506  1    67.25  ? 209 ILE C O   1 
ATOM   6227 C  CB  . ILE C 1 213 ? -57.221 18.965  52.392  1    72.96  ? 209 ILE C CB  1 
ATOM   6228 C  CG1 . ILE C 1 213 ? -58.657 19.34   52.711  1    76.22  ? 209 ILE C CG1 1 
ATOM   6229 C  CG2 . ILE C 1 213 ? -56.224 19.91   53.062  1    77.44  ? 209 ILE C CG2 1 
ATOM   6230 C  CD1 . ILE C 1 213 ? -59.647 18.221  52.429  1    82.15  ? 209 ILE C CD1 1 
ATOM   6231 N  N   . ASP C 1 214 ? -56.176 21.015  50.06   1    65.77  ? 210 ASP C N   1 
ATOM   6232 C  CA  . ASP C 1 214 ? -56.23  22.271  49.333  1    66.05  ? 210 ASP C CA  1 
ATOM   6233 C  C   . ASP C 1 214 ? -56.34  22.003  47.837  1    65.56  ? 210 ASP C C   1 
ATOM   6234 O  O   . ASP C 1 214 ? -57.071 22.707  47.142  1    66.46  ? 210 ASP C O   1 
ATOM   6235 C  CB  . ASP C 1 214 ? -55.012 23.134  49.585  1    68.21  ? 210 ASP C CB  1 
ATOM   6236 C  CG  . ASP C 1 214 ? -55.102 24.546  49.032  1    71.86  ? 210 ASP C CG  1 
ATOM   6237 O  OD1 . ASP C 1 214 ? -56.17  25.154  49.199  1    77.55  ? 210 ASP C OD1 1 
ATOM   6238 O  OD2 . ASP C 1 214 ? -54.098 25.044  48.479  1    71.27  ? 210 ASP C OD2 1 
ATOM   6239 N  N   . GLN C 1 215 ? -55.631 20.968  47.365  1    61.27  ? 211 GLN C N   1 
ATOM   6240 C  CA  . GLN C 1 215 ? -55.661 20.575  45.968  1    59.43  ? 211 GLN C CA  1 
ATOM   6241 C  C   . GLN C 1 215 ? -57.083 20.179  45.576  1    62.31  ? 211 GLN C C   1 
ATOM   6242 O  O   . GLN C 1 215 ? -57.577 20.627  44.537  1    60.54  ? 211 GLN C O   1 
ATOM   6243 C  CB  . GLN C 1 215 ? -54.728 19.39   45.733  1    56.2   ? 211 GLN C CB  1 
ATOM   6244 C  CG  . GLN C 1 215 ? -54.456 19.089  44.267  1    55.54  ? 211 GLN C CG  1 
ATOM   6245 C  CD  . GLN C 1 215 ? -53.634 20.169  43.593  1    57.02  ? 211 GLN C CD  1 
ATOM   6246 O  OE1 . GLN C 1 215 ? -52.828 20.868  44.225  1    55.55  ? 211 GLN C OE1 1 
ATOM   6247 N  NE2 . GLN C 1 215 ? -53.863 20.345  42.302  1    56.13  ? 211 GLN C NE2 1 
ATOM   6248 N  N   . LEU C 1 216 ? -57.72  19.354  46.427  1    65.02  ? 212 LEU C N   1 
ATOM   6249 C  CA  . LEU C 1 216 ? -59.082 18.878  46.221  1    66.7   ? 212 LEU C CA  1 
ATOM   6250 C  C   . LEU C 1 216 ? -60.026 20.07   46.119  1    68.03  ? 212 LEU C C   1 
ATOM   6251 O  O   . LEU C 1 216 ? -60.818 20.156  45.181  1    71.27  ? 212 LEU C O   1 
ATOM   6252 C  CB  . LEU C 1 216 ? -59.523 17.932  47.336  1    67.06  ? 212 LEU C CB  1 
ATOM   6253 C  CG  . LEU C 1 216 ? -59.105 16.469  47.178  1    70.26  ? 212 LEU C CG  1 
ATOM   6254 C  CD1 . LEU C 1 216 ? -59.455 15.666  48.417  1    71.53  ? 212 LEU C CD1 1 
ATOM   6255 C  CD2 . LEU C 1 216 ? -59.794 15.863  45.959  1    74.11  ? 212 LEU C CD2 1 
ATOM   6256 N  N   . PHE C 1 217 ? -59.933 20.978  47.097  1    65.35  ? 213 PHE C N   1 
ATOM   6257 C  CA  . PHE C 1 217 ? -60.837 22.109  47.16   1    65.22  ? 213 PHE C CA  1 
ATOM   6258 C  C   . PHE C 1 217 ? -60.646 22.974  45.92   1    65.74  ? 213 PHE C C   1 
ATOM   6259 O  O   . PHE C 1 217 ? -61.624 23.436  45.354  1    65.57  ? 213 PHE C O   1 
ATOM   6260 C  CB  . PHE C 1 217 ? -60.65  22.89   48.463  1    67.76  ? 213 PHE C CB  1 
ATOM   6261 C  CG  . PHE C 1 217 ? -61.144 22.254  49.761  1    67.41  ? 213 PHE C CG  1 
ATOM   6262 C  CD1 . PHE C 1 217 ? -61.672 20.964  49.8    1    66.63  ? 213 PHE C CD1 1 
ATOM   6263 C  CD2 . PHE C 1 217 ? -61.042 22.964  50.955  1    67.96  ? 213 PHE C CD2 1 
ATOM   6264 C  CE1 . PHE C 1 217 ? -62.1   20.426  51.007  1    69.42  ? 213 PHE C CE1 1 
ATOM   6265 C  CE2 . PHE C 1 217 ? -61.466 22.425  52.164  1    70.03  ? 213 PHE C CE2 1 
ATOM   6266 C  CZ  . PHE C 1 217 ? -61.99  21.15   52.193  1    71.17  ? 213 PHE C CZ  1 
ATOM   6267 N  N   . ARG C 1 218 ? -59.392 23.157  45.476  1    66.32  ? 214 ARG C N   1 
ATOM   6268 C  CA  . ARG C 1 218 ? -59.075 23.982  44.316  1    65.68  ? 214 ARG C CA  1 
ATOM   6269 C  C   . ARG C 1 218 ? -59.688 23.401  43.041  1    68.05  ? 214 ARG C C   1 
ATOM   6270 O  O   . ARG C 1 218 ? -60.075 24.153  42.148  1    70.83  ? 214 ARG C O   1 
ATOM   6271 C  CB  . ARG C 1 218 ? -57.564 24.116  44.13   1    63.35  ? 214 ARG C CB  1 
ATOM   6272 C  CG  . ARG C 1 218 ? -56.93  25.117  45.086  1    63.62  ? 214 ARG C CG  1 
ATOM   6273 C  CD  . ARG C 1 218 ? -55.406 25.125  44.925  1    61.76  ? 214 ARG C CD  1 
ATOM   6274 N  NE  . ARG C 1 218 ? -54.782 26.073  45.847  1    62.94  ? 214 ARG C NE  1 
ATOM   6275 C  CZ  . ARG C 1 218 ? -54.763 27.373  45.652  1    64.83  ? 214 ARG C CZ  1 
ATOM   6276 N  NH1 . ARG C 1 218 ? -55.209 27.855  44.507  1    66.38  ? 214 ARG C NH1 1 
ATOM   6277 N  NH2 . ARG C 1 218 ? -54.293 28.166  46.598  1    64.97  ? 214 ARG C NH2 1 
ATOM   6278 N  N   . ILE C 1 219 ? -59.76  22.081  42.959  1    67.12  ? 215 ILE C N   1 
ATOM   6279 C  CA  . ILE C 1 219 ? -60.348 21.424  41.762  1    69.99  ? 215 ILE C CA  1 
ATOM   6280 C  C   . ILE C 1 219 ? -61.872 21.505  41.884  1    78.2   ? 215 ILE C C   1 
ATOM   6281 O  O   . ILE C 1 219 ? -62.517 22.022  40.95   1    78.93  ? 215 ILE C O   1 
ATOM   6282 C  CB  . ILE C 1 219 ? -59.856 19.969  41.671  1    67.4   ? 215 ILE C CB  1 
ATOM   6283 C  CG1 . ILE C 1 219 ? -58.376 19.904  41.302  1    63.95  ? 215 ILE C CG1 1 
ATOM   6284 C  CG2 . ILE C 1 219 ? -60.716 19.145  40.713  1    67.01  ? 215 ILE C CG2 1 
ATOM   6285 C  CD1 . ILE C 1 219 ? -57.692 18.616  41.719  1    59.48  ? 215 ILE C CD1 1 
ATOM   6286 N  N   . PHE C 1 220 ? -62.408 21.041  43.011  1    82.08  ? 216 PHE C N   1 
ATOM   6287 C  CA  . PHE C 1 220 ? -63.876 21.035  43.225  1    84.54  ? 216 PHE C CA  1 
ATOM   6288 C  C   . PHE C 1 220 ? -64.453 22.393  42.859  1    88.65  ? 216 PHE C C   1 
ATOM   6289 O  O   . PHE C 1 220 ? -65.409 22.461  42.077  1    101.63 ? 216 PHE C O   1 
ATOM   6290 C  CB  . PHE C 1 220 ? -64.136 20.644  44.679  1    84.16  ? 216 PHE C CB  1 
ATOM   6291 C  CG  . PHE C 1 220 ? -63.839 19.186  44.994  1    88.12  ? 216 PHE C CG  1 
ATOM   6292 C  CD1 . PHE C 1 220 ? -63.668 18.257  43.975  1    87.39  ? 216 PHE C CD1 1 
ATOM   6293 C  CD2 . PHE C 1 220 ? -63.729 18.747  46.307  1    93.72  ? 216 PHE C CD2 1 
ATOM   6294 C  CE1 . PHE C 1 220 ? -63.394 16.931  44.264  1    87.74  ? 216 PHE C CE1 1 
ATOM   6295 C  CE2 . PHE C 1 220 ? -63.458 17.419  46.589  1    94.73  ? 216 PHE C CE2 1 
ATOM   6296 C  CZ  . PHE C 1 220 ? -63.295 16.515  45.568  1    92.1   ? 216 PHE C CZ  1 
ATOM   6297 N  N   . ARG C 1 221 ? -63.876 23.462  43.391  1    84.8   ? 217 ARG C N   1 
ATOM   6298 C  CA  . ARG C 1 221 ? -64.456 24.802  43.142  1    88.01  ? 217 ARG C CA  1 
ATOM   6299 C  C   . ARG C 1 221 ? -64.457 25.113  41.646  1    91.45  ? 217 ARG C C   1 
ATOM   6300 O  O   . ARG C 1 221 ? -65.487 25.609  41.161  1    94.71  ? 217 ARG C O   1 
ATOM   6301 C  CB  . ARG C 1 221 ? -63.68  25.904  43.867  1    84.77  ? 217 ARG C CB  1 
ATOM   6302 C  CG  . ARG C 1 221 ? -62.18  25.966  43.643  1    82.42  ? 217 ARG C CG  1 
ATOM   6303 C  CD  . ARG C 1 221 ? -61.736 27.33   43.176  1    83.04  ? 217 ARG C CD  1 
ATOM   6304 N  NE  . ARG C 1 221 ? -60.404 27.634  43.702  1    84.3   ? 217 ARG C NE  1 
ATOM   6305 C  CZ  . ARG C 1 221 ? -60.176 28.548  44.628  1    82.72  ? 217 ARG C CZ  1 
ATOM   6306 N  NH1 . ARG C 1 221 ? -59.041 29.219  44.622  1    89.49  ? 217 ARG C NH1 1 
ATOM   6307 N  NH2 . ARG C 1 221 ? -61.09  28.792  45.547  1    74.96  ? 217 ARG C NH2 1 
ATOM   6308 N  N   . THR C 1 222 ? -63.367 24.823  40.941  1    94.73  ? 218 THR C N   1 
ATOM   6309 C  CA  . THR C 1 222 ? -63.268 25.239  39.53   1    98.69  ? 218 THR C CA  1 
ATOM   6310 C  C   . THR C 1 222 ? -64.232 24.464  38.672  1    96.59  ? 218 THR C C   1 
ATOM   6311 O  O   . THR C 1 222 ? -64.688 25.028  37.66   1    98.78  ? 218 THR C O   1 
ATOM   6312 C  CB  . THR C 1 222 ? -61.822 25.059  39.08   1    99.93  ? 218 THR C CB  1 
ATOM   6313 O  OG1 . THR C 1 222 ? -61.078 25.891  39.964  1    101.93 ? 218 THR C OG1 1 
ATOM   6314 C  CG2 . THR C 1 222 ? -61.581 25.502  37.65   1    97.56  ? 218 THR C CG2 1 
ATOM   6315 N  N   . LEU C 1 223 ? -64.585 23.244  39.062  1    92.56  ? 219 LEU C N   1 
ATOM   6316 C  CA  . LEU C 1 223 ? -65.411 22.437  38.178  1    98.76  ? 219 LEU C CA  1 
ATOM   6317 C  C   . LEU C 1 223 ? -66.723 22.032  38.845  1    101.26 ? 219 LEU C C   1 
ATOM   6318 O  O   . LEU C 1 223 ? -67.376 21.122  38.353  1    103.82 ? 219 LEU C O   1 
ATOM   6319 C  CB  . LEU C 1 223 ? -64.605 21.209  37.772  1    100.87 ? 219 LEU C CB  1 
ATOM   6320 C  CG  . LEU C 1 223 ? -63.18  21.498  37.283  1    109.55 ? 219 LEU C CG  1 
ATOM   6321 C  CD1 . LEU C 1 223 ? -62.296 20.272  37.501  1    106.9  ? 219 LEU C CD1 1 
ATOM   6322 C  CD2 . LEU C 1 223 ? -63.137 21.944  35.822  1    107.76 ? 219 LEU C CD2 1 
ATOM   6323 N  N   . GLY C 1 224 ? -67.12  22.713  39.93   1    101.12 ? 220 GLY C N   1 
ATOM   6324 C  CA  . GLY C 1 224 ? -68.325 22.35   40.664  1    101.73 ? 220 GLY C CA  1 
ATOM   6325 C  C   . GLY C 1 224 ? -68.134 21.017  41.388  1    110.25 ? 220 GLY C C   1 
ATOM   6326 O  O   . GLY C 1 224 ? -67.141 20.318  41.16   1    116.05 ? 220 GLY C O   1 
ATOM   6327 N  N   . THR C 1 225 ? -69.098 20.66   42.252  1    116.63 ? 221 THR C N   1 
ATOM   6328 C  CA  . THR C 1 225 ? -69.012 19.489  43.125  1    113.8  ? 221 THR C CA  1 
ATOM   6329 C  C   . THR C 1 225 ? -67.877 19.681  44.134  1    103.02 ? 221 THR C C   1 
ATOM   6330 O  O   . THR C 1 225 ? -67.988 20.626  44.948  1    91.75  ? 221 THR C O   1 
ATOM   6331 C  CB  . THR C 1 225 ? -68.9   18.159  42.358  1    109.33 ? 221 THR C CB  1 
ATOM   6332 O  OG1 . THR C 1 225 ? -67.548 17.969  41.939  1    103.56 ? 221 THR C OG1 1 
ATOM   6333 C  CG2 . THR C 1 225 ? -69.835 18.057  41.164  1    104.57 ? 221 THR C CG2 1 
ATOM   6334 N  N   . SER C 1 253 ? -67.664 29.473  32.696  1    104.72 ? 249 SER C N   1 
ATOM   6335 C  CA  . SER C 1 253 ? -66.336 29.519  33.355  1    109.8  ? 249 SER C CA  1 
ATOM   6336 C  C   . SER C 1 253 ? -65.256 29.955  32.362  1    114.85 ? 249 SER C C   1 
ATOM   6337 O  O   . SER C 1 253 ? -64.947 29.267  31.385  1    103.18 ? 249 SER C O   1 
ATOM   6338 C  CB  . SER C 1 253 ? -66.005 28.2    34.029  1    114.38 ? 249 SER C CB  1 
ATOM   6339 O  OG  . SER C 1 253 ? -66.729 28.05   35.244  1    112.29 ? 249 SER C OG  1 
ATOM   6340 N  N   . LYS C 1 254 ? -64.692 31.135  32.641  1    121.7  ? 250 LYS C N   1 
ATOM   6341 C  CA  . LYS C 1 254 ? -63.542 31.657  31.923  1    124.49 ? 250 LYS C CA  1 
ATOM   6342 C  C   . LYS C 1 254 ? -62.336 31.618  32.854  1    127.18 ? 250 LYS C C   1 
ATOM   6343 O  O   . LYS C 1 254 ? -61.773 32.664  33.19   1    116.27 ? 250 LYS C O   1 
ATOM   6344 C  CB  . LYS C 1 254 ? -63.778 33.087  31.428  1    121.12 ? 250 LYS C CB  1 
ATOM   6345 C  CG  . LYS C 1 254 ? -64.827 33.307  30.351  1    129.85 ? 250 LYS C CG  1 
ATOM   6346 C  CD  . LYS C 1 254 ? -65.037 34.754  29.912  1    138.48 ? 250 LYS C CD  1 
ATOM   6347 C  CE  . LYS C 1 254 ? -66.068 34.88   28.834  1    144.24 ? 250 LYS C CE  1 
ATOM   6348 N  NZ  . LYS C 1 254 ? -66.253 36.288  28.462  1    152.43 ? 250 LYS C NZ  1 
ATOM   6349 N  N   . VAL C 1 255 ? -61.988 30.393  33.278  1    130.44 ? 251 VAL C N   1 
ATOM   6350 C  CA  . VAL C 1 255 ? -60.772 30.104  34.018  1    131.27 ? 251 VAL C CA  1 
ATOM   6351 C  C   . VAL C 1 255 ? -59.587 30.351  33.089  1    128.64 ? 251 VAL C C   1 
ATOM   6352 O  O   . VAL C 1 255 ? -58.497 30.698  33.54   1    132.61 ? 251 VAL C O   1 
ATOM   6353 C  CB  . VAL C 1 255 ? -60.769 28.658  34.551  1    136.24 ? 251 VAL C CB  1 
ATOM   6354 C  CG1 . VAL C 1 255 ? -59.561 28.391  35.446  1    133.21 ? 251 VAL C CG1 1 
ATOM   6355 C  CG2 . VAL C 1 255 ? -62.059 28.326  35.295  1    140.82 ? 251 VAL C CG2 1 
ATOM   6356 N  N   . VAL C 1 256 ? -59.82  30.142  31.79   1    127.79 ? 252 VAL C N   1 
ATOM   6357 C  CA  . VAL C 1 256 ? -58.864 30.452  30.74   1    122.97 ? 252 VAL C CA  1 
ATOM   6358 C  C   . VAL C 1 256 ? -59.519 31.416  29.736  1    123.47 ? 252 VAL C C   1 
ATOM   6359 O  O   . VAL C 1 256 ? -60.329 30.999  28.904  1    118.8  ? 252 VAL C O   1 
ATOM   6360 C  CB  . VAL C 1 256 ? -58.393 29.123  30.111  1    111.38 ? 252 VAL C CB  1 
ATOM   6361 C  CG1 . VAL C 1 256 ? -57.856 29.333  28.706  1    123.49 ? 252 VAL C CG1 1 
ATOM   6362 C  CG2 . VAL C 1 256 ? -57.353 28.397  30.968  1    100.82 ? 252 VAL C CG2 1 
ATOM   6363 N  N   . PRO C 1 257 ? -59.237 32.746  29.808  1    128.06 ? 253 PRO C N   1 
ATOM   6364 C  CA  . PRO C 1 257 ? -59.83  33.724  28.883  1    126.18 ? 253 PRO C CA  1 
ATOM   6365 C  C   . PRO C 1 257 ? -59.498 33.568  27.396  1    119.99 ? 253 PRO C C   1 
ATOM   6366 O  O   . PRO C 1 257 ? -60.409 33.43   26.587  1    120.42 ? 253 PRO C O   1 
ATOM   6367 C  CB  . PRO C 1 257 ? -59.477 35.128  29.445  1    116.44 ? 253 PRO C CB  1 
ATOM   6368 C  CG  . PRO C 1 257 ? -58.971 34.844  30.843  1    117.15 ? 253 PRO C CG  1 
ATOM   6369 C  CD  . PRO C 1 257 ? -58.406 33.41   30.828  1    125.84 ? 253 PRO C CD  1 
ATOM   6370 N  N   . PRO C 1 258 ? -58.214 33.558  26.959  1    111.47 ? 254 PRO C N   1 
ATOM   6371 C  CA  . PRO C 1 258 ? -57.91  33.612  25.522  1    104.65 ? 254 PRO C CA  1 
ATOM   6372 C  C   . PRO C 1 258 ? -58.353 32.402  24.703  1    102.9  ? 254 PRO C C   1 
ATOM   6373 O  O   . PRO C 1 258 ? -58.071 32.332  23.512  1    101.63 ? 254 PRO C O   1 
ATOM   6374 C  CB  . PRO C 1 258 ? -56.376 33.758  25.456  1    101.39 ? 254 PRO C CB  1 
ATOM   6375 C  CG  . PRO C 1 258 ? -55.931 34.063  26.876  1    98.11  ? 254 PRO C CG  1 
ATOM   6376 C  CD  . PRO C 1 258 ? -57.001 33.507  27.796  1    101.25 ? 254 PRO C CD  1 
ATOM   6377 N  N   . LEU C 1 259 ? -59.02  31.438  25.345  1    98.69  ? 255 LEU C N   1 
ATOM   6378 C  CA  . LEU C 1 259 ? -59.295 30.152  24.721  1    93.26  ? 255 LEU C CA  1 
ATOM   6379 C  C   . LEU C 1 259 ? -60.638 30.16   23.995  1    98.89  ? 255 LEU C C   1 
ATOM   6380 O  O   . LEU C 1 259 ? -61.671 30.472  24.586  1    96.52  ? 255 LEU C O   1 
ATOM   6381 C  CB  . LEU C 1 259 ? -59.268 29.076  25.804  1    86.58  ? 255 LEU C CB  1 
ATOM   6382 C  CG  . LEU C 1 259 ? -58.895 27.674  25.32   1    85.14  ? 255 LEU C CG  1 
ATOM   6383 C  CD1 . LEU C 1 259 ? -57.659 27.727  24.436  1    80.6   ? 255 LEU C CD1 1 
ATOM   6384 C  CD2 . LEU C 1 259 ? -58.66  26.743  26.499  1    82.4   ? 255 LEU C CD2 1 
ATOM   6385 N  N   . ASP C 1 260 ? -60.612 29.764  22.716  1    107.61 ? 256 ASP C N   1 
ATOM   6386 C  CA  . ASP C 1 260 ? -61.816 29.662  21.895  1    111.01 ? 256 ASP C CA  1 
ATOM   6387 C  C   . ASP C 1 260 ? -62.717 28.564  22.466  1    108.26 ? 256 ASP C C   1 
ATOM   6388 O  O   . ASP C 1 260 ? -62.363 27.92   23.461  1    101.59 ? 256 ASP C O   1 
ATOM   6389 C  CB  . ASP C 1 260 ? -61.486 29.44   20.421  1    109.45 ? 256 ASP C CB  1 
ATOM   6390 C  CG  . ASP C 1 260 ? -60.666 28.187  20.124  1    104.19 ? 256 ASP C CG  1 
ATOM   6391 O  OD1 . ASP C 1 260 ? -59.434 28.199  20.358  1    94.38  ? 256 ASP C OD1 1 
ATOM   6392 O  OD2 . ASP C 1 260 ? -61.281 27.187  19.72   1    105.17 ? 256 ASP C OD2 1 
ATOM   6393 N  N   . GLU C 1 261 ? -63.87  28.354  21.816  1    105.94 ? 257 GLU C N   1 
ATOM   6394 C  CA  . GLU C 1 261 ? -64.865 27.386  22.258  1    103.02 ? 257 GLU C CA  1 
ATOM   6395 C  C   . GLU C 1 261 ? -64.399 25.946  22.013  1    98.25  ? 257 GLU C C   1 
ATOM   6396 O  O   . GLU C 1 261 ? -64.787 25.025  22.733  1    93.47  ? 257 GLU C O   1 
ATOM   6397 C  CB  . GLU C 1 261 ? -66.186 27.617  21.527  1    103.52 ? 257 GLU C CB  1 
ATOM   6398 C  CG  . GLU C 1 261 ? -67.217 26.542  21.862  1    106.62 ? 257 GLU C CG  1 
ATOM   6399 C  CD  . GLU C 1 261 ? -68.474 26.526  21.014  1    115.93 ? 257 GLU C CD  1 
ATOM   6400 O  OE1 . GLU C 1 261 ? -69.337 25.694  21.348  1    121.11 ? 257 GLU C OE1 1 
ATOM   6401 O  OE2 . GLU C 1 261 ? -68.6   27.313  20.049  1    114.12 ? 257 GLU C OE2 1 
ATOM   6402 N  N   . ASP C 1 262 ? -63.61  25.74   20.953  1    95.02  ? 258 ASP C N   1 
ATOM   6403 C  CA  . ASP C 1 262 ? -63.051 24.426  20.702  1    96.43  ? 258 ASP C CA  1 
ATOM   6404 C  C   . ASP C 1 262 ? -62.095 24.086  21.849  1    94.57  ? 258 ASP C C   1 
ATOM   6405 O  O   . ASP C 1 262 ? -62.149 22.988  22.412  1    92.36  ? 258 ASP C O   1 
ATOM   6406 C  CB  . ASP C 1 262 ? -62.42  24.325  19.317  1    97.76  ? 258 ASP C CB  1 
ATOM   6407 C  CG  . ASP C 1 262 ? -63.37  24.256  18.13   1    97.99  ? 258 ASP C CG  1 
ATOM   6408 O  OD1 . ASP C 1 262 ? -64.455 23.673  18.299  1    98.22  ? 258 ASP C OD1 1 
ATOM   6409 O  OD2 . ASP C 1 262 ? -62.996 24.746  17.037  1    95.25  ? 258 ASP C OD2 1 
ATOM   6410 N  N   . GLY C 1 263 ? -61.226 25.056  22.183  1    87.76  ? 259 GLY C N   1 
ATOM   6411 C  CA  . GLY C 1 263 ? -60.265 24.908  23.256  1    78.94  ? 259 GLY C CA  1 
ATOM   6412 C  C   . GLY C 1 263 ? -60.937 24.553  24.579  1    78.06  ? 259 GLY C C   1 
ATOM   6413 O  O   . GLY C 1 263 ? -60.549 23.584  25.228  1    73.61  ? 259 GLY C O   1 
ATOM   6414 N  N   . ARG C 1 264 ? -61.947 25.336  24.968  1    81.59  ? 260 ARG C N   1 
ATOM   6415 C  CA  . ARG C 1 264 ? -62.637 25.136  26.235  1    83.66  ? 260 ARG C CA  1 
ATOM   6416 C  C   . ARG C 1 264 ? -63.272 23.75   26.273  1    78.89  ? 260 ARG C C   1 
ATOM   6417 O  O   . ARG C 1 264 ? -63.337 23.113  27.326  1    78.53  ? 260 ARG C O   1 
ATOM   6418 C  CB  . ARG C 1 264 ? -63.708 26.208  26.478  1    96.06  ? 260 ARG C CB  1 
ATOM   6419 C  CG  . ARG C 1 264 ? -63.17  27.482  27.118  1    107.94 ? 260 ARG C CG  1 
ATOM   6420 C  CD  . ARG C 1 264 ? -64.264 28.414  27.621  1    116.84 ? 260 ARG C CD  1 
ATOM   6421 N  NE  . ARG C 1 264 ? -65.291 28.741  26.622  1    121.52 ? 260 ARG C NE  1 
ATOM   6422 C  CZ  . ARG C 1 264 ? -65.135 29.594  25.616  1    119.31 ? 260 ARG C CZ  1 
ATOM   6423 N  NH1 . ARG C 1 264 ? -64.018 30.292  25.513  1    122.3  ? 260 ARG C NH1 1 
ATOM   6424 N  NH2 . ARG C 1 264 ? -66.102 29.77   24.735  1    112.37 ? 260 ARG C NH2 1 
ATOM   6425 N  N   . SER C 1 265 ? -63.753 23.31   25.111  1    75.81  ? 261 SER C N   1 
ATOM   6426 C  CA  . SER C 1 265 ? -64.385 22.011  24.975  1    75.11  ? 261 SER C CA  1 
ATOM   6427 C  C   . SER C 1 265 ? -63.38  20.893  25.267  1    70.87  ? 261 SER C C   1 
ATOM   6428 O  O   . SER C 1 265 ? -63.646 19.994  26.056  1    68.92  ? 261 SER C O   1 
ATOM   6429 C  CB  . SER C 1 265 ? -64.99  21.877  23.606  1    77.65  ? 261 SER C CB  1 
ATOM   6430 O  OG  . SER C 1 265 ? -65.194 20.507  23.298  1    78.88  ? 261 SER C OG  1 
ATOM   6431 N  N   . LEU C 1 266 ? -62.213 20.966  24.631  1    71.3   ? 262 LEU C N   1 
ATOM   6432 C  CA  . LEU C 1 266 ? -61.16  19.975  24.798  1    70.12  ? 262 LEU C CA  1 
ATOM   6433 C  C   . LEU C 1 266 ? -60.731 19.924  26.263  1    67.83  ? 262 LEU C C   1 
ATOM   6434 O  O   . LEU C 1 266 ? -60.748 18.862  26.89   1    66.97  ? 262 LEU C O   1 
ATOM   6435 C  CB  . LEU C 1 266 ? -59.999 20.324  23.859  1    68.37  ? 262 LEU C CB  1 
ATOM   6436 C  CG  . LEU C 1 266 ? -58.756 19.428  23.952  1    65.75  ? 262 LEU C CG  1 
ATOM   6437 C  CD1 . LEU C 1 266 ? -59.147 17.956  23.979  1    66.53  ? 262 LEU C CD1 1 
ATOM   6438 C  CD2 . LEU C 1 266 ? -57.822 19.706  22.784  1    64.01  ? 262 LEU C CD2 1 
ATOM   6439 N  N   . LEU C 1 267 ? -60.381 21.096  26.8    1    66.31  ? 263 LEU C N   1 
ATOM   6440 C  CA  . LEU C 1 267 ? -59.887 21.228  28.162  1    64.9   ? 263 LEU C CA  1 
ATOM   6441 C  C   . LEU C 1 267 ? -60.834 20.552  29.149  1    65.51  ? 263 LEU C C   1 
ATOM   6442 O  O   . LEU C 1 267 ? -60.394 19.773  29.999  1    61.72  ? 263 LEU C O   1 
ATOM   6443 C  CB  . LEU C 1 267 ? -59.697 22.715  28.476  1    62.44  ? 263 LEU C CB  1 
ATOM   6444 C  CG  . LEU C 1 267 ? -59.231 23.065  29.89   1    58.85  ? 263 LEU C CG  1 
ATOM   6445 C  CD1 . LEU C 1 267 ? -57.883 22.388  30.192  1    56.47  ? 263 LEU C CD1 1 
ATOM   6446 C  CD2 . LEU C 1 267 ? -59.136 24.574  30.019  1    58.83  ? 263 LEU C CD2 1 
ATOM   6447 N  N   . SER C 1 268 ? -62.134 20.88   29.03   1    69.05  ? 264 SER C N   1 
ATOM   6448 C  CA  . SER C 1 268 ? -63.142 20.374  29.955  1    71.39  ? 264 SER C CA  1 
ATOM   6449 C  C   . SER C 1 268 ? -63.268 18.855  29.829  1    69.07  ? 264 SER C C   1 
ATOM   6450 O  O   . SER C 1 268 ? -63.443 18.161  30.825  1    70.43  ? 264 SER C O   1 
ATOM   6451 C  CB  . SER C 1 268 ? -64.457 21.081  29.8    1    72.19  ? 264 SER C CB  1 
ATOM   6452 O  OG  . SER C 1 268 ? -64.954 20.877  28.488  1    83.34  ? 264 SER C OG  1 
ATOM   6453 N  N   . GLN C 1 269 ? -63.12  18.346  28.604  1    68.5   ? 265 GLN C N   1 
ATOM   6454 C  CA  . GLN C 1 269 ? -63.113 16.912  28.357  1    71.45  ? 265 GLN C CA  1 
ATOM   6455 C  C   . GLN C 1 269 ? -61.856 16.249  28.924  1    70.82  ? 265 GLN C C   1 
ATOM   6456 O  O   . GLN C 1 269 ? -61.887 15.086  29.326  1    74.77  ? 265 GLN C O   1 
ATOM   6457 C  CB  . GLN C 1 269 ? -63.287 16.634  26.871  1    72.08  ? 265 GLN C CB  1 
ATOM   6458 C  CG  . GLN C 1 269 ? -64.715 16.876  26.399  1    75.52  ? 265 GLN C CG  1 
ATOM   6459 C  CD  . GLN C 1 269 ? -64.843 16.668  24.908  1    79.45  ? 265 GLN C CD  1 
ATOM   6460 O  OE1 . GLN C 1 269 ? -65.084 17.602  24.125  1    80.75  ? 265 GLN C OE1 1 
ATOM   6461 N  NE2 . GLN C 1 269 ? -64.608 15.427  24.51   1    79.59  ? 265 GLN C NE2 1 
ATOM   6462 N  N   . MET C 1 270 ? -60.748 16.994  28.974  1    67.2   ? 266 MET C N   1 
ATOM   6463 C  CA  . MET C 1 270 ? -59.523 16.473  29.565  1    63.22  ? 266 MET C CA  1 
ATOM   6464 C  C   . MET C 1 270 ? -59.595 16.573  31.09   1    61.22  ? 266 MET C C   1 
ATOM   6465 O  O   . MET C 1 270 ? -59.016 15.765  31.801  1    58.75  ? 266 MET C O   1 
ATOM   6466 C  CB  . MET C 1 270 ? -58.291 17.224  29.038  1    59.83  ? 266 MET C CB  1 
ATOM   6467 C  CG  . MET C 1 270 ? -58.027 16.97   27.581  1    56.19  ? 266 MET C CG  1 
ATOM   6468 S  SD  . MET C 1 270 ? -56.691 18.023  26.999  1    59.84  ? 266 MET C SD  1 
ATOM   6469 C  CE  . MET C 1 270 ? -55.196 17.148  27.507  1    49.21  ? 266 MET C CE  1 
ATOM   6470 N  N   . LEU C 1 271 ? -60.302 17.58   31.597  1    65.07  ? 267 LEU C N   1 
ATOM   6471 C  CA  . LEU C 1 271 ? -60.362 17.789  33.034  1    66.63  ? 267 LEU C CA  1 
ATOM   6472 C  C   . LEU C 1 271 ? -61.675 17.292  33.622  1    69.5   ? 267 LEU C C   1 
ATOM   6473 O  O   . LEU C 1 271 ? -62.066 17.763  34.675  1    74.28  ? 267 LEU C O   1 
ATOM   6474 C  CB  . LEU C 1 271 ? -60.166 19.27   33.339  1    65.6   ? 267 LEU C CB  1 
ATOM   6475 C  CG  . LEU C 1 271 ? -58.73  19.772  33.201  1    63.6   ? 267 LEU C CG  1 
ATOM   6476 C  CD1 . LEU C 1 271 ? -58.734 21.241  33.61   1    67.87  ? 267 LEU C CD1 1 
ATOM   6477 C  CD2 . LEU C 1 271 ? -57.766 18.927  34.041  1    58.34  ? 267 LEU C CD2 1 
ATOM   6478 N  N   . HIS C 1 272 ? -62.317 16.318  32.969  1    72.3   ? 268 HIS C N   1 
ATOM   6479 C  CA  . HIS C 1 272 ? -63.52  15.696  33.495  1    77.22  ? 268 HIS C CA  1 
ATOM   6480 C  C   . HIS C 1 272 ? -63.189 14.934  34.776  1    73.84  ? 268 HIS C C   1 
ATOM   6481 O  O   . HIS C 1 272 ? -62.122 14.338  34.886  1    72.94  ? 268 HIS C O   1 
ATOM   6482 C  CB  . HIS C 1 272 ? -64.153 14.805  32.425  1    82.29  ? 268 HIS C CB  1 
ATOM   6483 C  CG  . HIS C 1 272 ? -65.604 14.578  32.615  1    92.67  ? 268 HIS C CG  1 
ATOM   6484 N  ND1 . HIS C 1 272 ? -66.106 13.957  33.74   1    98.86  ? 268 HIS C ND1 1 
ATOM   6485 C  CD2 . HIS C 1 272 ? -66.662 14.906  31.855  1    96.64  ? 268 HIS C CD2 1 
ATOM   6486 C  CE1 . HIS C 1 272 ? -67.429 13.894  33.65   1    98.77  ? 268 HIS C CE1 1 
ATOM   6487 N  NE2 . HIS C 1 272 ? -67.787 14.465  32.511  1    99.5   ? 268 HIS C NE2 1 
ATOM   6488 N  N   . TYR C 1 273 ? -64.122 14.948  35.733  1    78.22  ? 269 TYR C N   1 
ATOM   6489 C  CA  . TYR C 1 273 ? -63.902 14.364  37.045  1    81.05  ? 269 TYR C CA  1 
ATOM   6490 C  C   . TYR C 1 273 ? -63.963 12.828  36.991  1    79.53  ? 269 TYR C C   1 
ATOM   6491 O  O   . TYR C 1 273 ? -63.191 12.15   37.67   1    72.84  ? 269 TYR C O   1 
ATOM   6492 C  CB  . TYR C 1 273 ? -64.88  15.007  38.041  1    89.14  ? 269 TYR C CB  1 
ATOM   6493 C  CG  . TYR C 1 273 ? -64.765 14.434  39.448  1    112.13 ? 269 TYR C CG  1 
ATOM   6494 C  CD1 . TYR C 1 273 ? -65.432 13.254  39.808  1    121.51 ? 269 TYR C CD1 1 
ATOM   6495 C  CD2 . TYR C 1 273 ? -63.956 15.049  40.406  1    127.78 ? 269 TYR C CD2 1 
ATOM   6496 C  CE1 . TYR C 1 273 ? -65.31  12.71   41.079  1    138.2  ? 269 TYR C CE1 1 
ATOM   6497 C  CE2 . TYR C 1 273 ? -63.835 14.514  41.683  1    146.32 ? 269 TYR C CE2 1 
ATOM   6498 C  CZ  . TYR C 1 273 ? -64.505 13.342  42.018  1    153.36 ? 269 TYR C CZ  1 
ATOM   6499 O  OH  . TYR C 1 273 ? -64.385 12.819  43.278  1    159.58 ? 269 TYR C OH  1 
ATOM   6500 N  N   . ASP C 1 274 ? -64.917 12.269  36.229  1    79.28  ? 270 ASP C N   1 
ATOM   6501 C  CA  . ASP C 1 274 ? -65.02  10.829  36.108  1    78.81  ? 270 ASP C CA  1 
ATOM   6502 C  C   . ASP C 1 274 ? -63.888 10.363  35.187  1    75.58  ? 270 ASP C C   1 
ATOM   6503 O  O   . ASP C 1 274 ? -63.867 10.747  34.016  1    72.91  ? 270 ASP C O   1 
ATOM   6504 C  CB  . ASP C 1 274 ? -66.406 10.392  35.645  1    80.57  ? 270 ASP C CB  1 
ATOM   6505 C  CG  . ASP C 1 274 ? -66.644 8.885   35.639  1    87.59  ? 270 ASP C CG  1 
ATOM   6506 O  OD1 . ASP C 1 274 ? -65.654 8.115   35.613  1    91.46  ? 270 ASP C OD1 1 
ATOM   6507 O  OD2 . ASP C 1 274 ? -67.82  8.483   35.74   1    93.66  ? 270 ASP C OD2 1 
ATOM   6508 N  N   . PRO C 1 275 ? -62.938 9.522   35.679  1    72.28  ? 271 PRO C N   1 
ATOM   6509 C  CA  . PRO C 1 275 ? -61.862 8.992   34.842  1    69.1   ? 271 PRO C CA  1 
ATOM   6510 C  C   . PRO C 1 275 ? -62.401 8.311   33.583  1    70.79  ? 271 PRO C C   1 
ATOM   6511 O  O   . PRO C 1 275 ? -61.772 8.379   32.528  1    68.13  ? 271 PRO C O   1 
ATOM   6512 C  CB  . PRO C 1 275 ? -61.104 7.995   35.745  1    66.81  ? 271 PRO C CB  1 
ATOM   6513 C  CG  . PRO C 1 275 ? -61.488 8.364   37.155  1    68.26  ? 271 PRO C CG  1 
ATOM   6514 C  CD  . PRO C 1 275 ? -62.864 9.015   37.063  1    72.75  ? 271 PRO C CD  1 
ATOM   6515 N  N   . ASN C 1 276 ? -63.571 7.665   33.706  1    71.88  ? 272 ASN C N   1 
ATOM   6516 C  CA  . ASN C 1 276 ? -64.191 6.943   32.597  1    71.83  ? 272 ASN C CA  1 
ATOM   6517 C  C   . ASN C 1 276 ? -64.707 7.91    31.531  1    69.64  ? 272 ASN C C   1 
ATOM   6518 O  O   . ASN C 1 276 ? -64.796 7.548   30.361  1    69.64  ? 272 ASN C O   1 
ATOM   6519 C  CB  . ASN C 1 276 ? -65.32  6.021   33.055  1    75.8   ? 272 ASN C CB  1 
ATOM   6520 C  CG  . ASN C 1 276 ? -64.917 5.087   34.173  1    78.66  ? 272 ASN C CG  1 
ATOM   6521 O  OD1 . ASN C 1 276 ? -63.922 4.358   34.067  1    83.54  ? 272 ASN C OD1 1 
ATOM   6522 N  ND2 . ASN C 1 276 ? -65.669 5.105   35.263  1    78.57  ? 272 ASN C ND2 1 
ATOM   6523 N  N   . LYS C 1 277 ? -65.068 9.131   31.939  1    72.3   ? 273 LYS C N   1 
ATOM   6524 C  CA  . LYS C 1 277 ? -65.679 10.079  31.015  1    75.81  ? 273 LYS C CA  1 
ATOM   6525 C  C   . LYS C 1 277 ? -64.634 11.035  30.457  1    73.77  ? 273 LYS C C   1 
ATOM   6526 O  O   . LYS C 1 277 ? -64.945 11.827  29.577  1    76.3   ? 273 LYS C O   1 
ATOM   6527 C  CB  . LYS C 1 277 ? -66.794 10.905  31.663  1    80.94  ? 273 LYS C CB  1 
ATOM   6528 C  CG  . LYS C 1 277 ? -68.044 10.125  32.068  1    90.36  ? 273 LYS C CG  1 
ATOM   6529 C  CD  . LYS C 1 277 ? -69.127 10.972  32.733  1    96.51  ? 273 LYS C CD  1 
ATOM   6530 C  CE  . LYS C 1 277 ? -70.413 10.274  33.145  1    93.04  ? 273 LYS C CE  1 
ATOM   6531 N  NZ  . LYS C 1 277 ? -71.32  11.237  33.785  1    90.31  ? 273 LYS C NZ  1 
ATOM   6532 N  N   . ARG C 1 278 ? -63.414 10.975  31.009  1    69.85  ? 274 ARG C N   1 
ATOM   6533 C  CA  . ARG C 1 278 ? -62.319 11.814  30.556  1    63.7   ? 274 ARG C CA  1 
ATOM   6534 C  C   . ARG C 1 278 ? -61.904 11.325  29.173  1    63.3   ? 274 ARG C C   1 
ATOM   6535 O  O   . ARG C 1 278 ? -61.842 10.111  28.947  1    62.38  ? 274 ARG C O   1 
ATOM   6536 C  CB  . ARG C 1 278 ? -61.198 11.721  31.591  1    60.08  ? 274 ARG C CB  1 
ATOM   6537 C  CG  . ARG C 1 278 ? -60.282 12.934  31.66   1    59.92  ? 274 ARG C CG  1 
ATOM   6538 C  CD  . ARG C 1 278 ? -59.311 12.812  32.835  1    56.3   ? 274 ARG C CD  1 
ATOM   6539 N  NE  . ARG C 1 278 ? -60.05  12.77   34.097  1    57.28  ? 274 ARG C NE  1 
ATOM   6540 C  CZ  . ARG C 1 278 ? -59.61  12.212  35.218  1    58.9   ? 274 ARG C CZ  1 
ATOM   6541 N  NH1 . ARG C 1 278 ? -58.429 11.597  35.253  1    56.2   ? 274 ARG C NH1 1 
ATOM   6542 N  NH2 . ARG C 1 278 ? -60.375 12.242  36.299  1    59.93  ? 274 ARG C NH2 1 
ATOM   6543 N  N   . ILE C 1 279 ? -61.654 12.275  28.262  1    59.65  ? 275 ILE C N   1 
ATOM   6544 C  CA  . ILE C 1 279 ? -61.199 11.958  26.924  1    61.81  ? 275 ILE C CA  1 
ATOM   6545 C  C   . ILE C 1 279 ? -59.883 11.175  27.002  1    66.83  ? 275 ILE C C   1 
ATOM   6546 O  O   . ILE C 1 279 ? -59.079 11.334  27.935  1    68.32  ? 275 ILE C O   1 
ATOM   6547 C  CB  . ILE C 1 279 ? -61.113 13.235  26.069  1    61.46  ? 275 ILE C CB  1 
ATOM   6548 C  CG1 . ILE C 1 279 ? -61.092 12.932  24.579  1    63.57  ? 275 ILE C CG1 1 
ATOM   6549 C  CG2 . ILE C 1 279 ? -59.951 14.146  26.465  1    58.95  ? 275 ILE C CG2 1 
ATOM   6550 C  CD1 . ILE C 1 279 ? -61.284 14.169  23.724  1    62.76  ? 275 ILE C CD1 1 
ATOM   6551 N  N   . SER C 1 280 ? -59.698 10.255  26.05   1    70.3   ? 276 SER C N   1 
ATOM   6552 C  CA  . SER C 1 280 ? -58.423 9.565   25.9    1    69.05  ? 276 SER C CA  1 
ATOM   6553 C  C   . SER C 1 280 ? -57.544 10.434  25.011  1    65.06  ? 276 SER C C   1 
ATOM   6554 O  O   . SER C 1 280 ? -58.071 11.309  24.311  1    61.81  ? 276 SER C O   1 
ATOM   6555 C  CB  . SER C 1 280 ? -58.608 8.188   25.29   1    76.83  ? 276 SER C CB  1 
ATOM   6556 O  OG  . SER C 1 280 ? -59.18  8.281   23.985  1    81.38  ? 276 SER C OG  1 
ATOM   6557 N  N   . ALA C 1 281 ? -56.222 10.196  25.056  1    61.43  ? 277 ALA C N   1 
ATOM   6558 C  CA  . ALA C 1 281 ? -55.301 10.918  24.19   1    59.76  ? 277 ALA C CA  1 
ATOM   6559 C  C   . ALA C 1 281 ? -55.69  10.702  22.723  1    62.3   ? 277 ALA C C   1 
ATOM   6560 O  O   . ALA C 1 281 ? -55.587 11.604  21.897  1    62.41  ? 277 ALA C O   1 
ATOM   6561 C  CB  . ALA C 1 281 ? -53.887 10.463  24.44   1    54.81  ? 277 ALA C CB  1 
ATOM   6562 N  N   . LYS C 1 282 ? -56.117 9.484   22.39   1    64.04  ? 278 LYS C N   1 
ATOM   6563 C  CA  . LYS C 1 282 ? -56.383 9.126   21.005  1    69.94  ? 278 LYS C CA  1 
ATOM   6564 C  C   . LYS C 1 282 ? -57.599 9.907   20.499  1    68.1   ? 278 LYS C C   1 
ATOM   6565 O  O   . LYS C 1 282 ? -57.544 10.555  19.458  1    67.45  ? 278 LYS C O   1 
ATOM   6566 C  CB  . LYS C 1 282 ? -56.488 7.598   20.883  1    70.8   ? 278 LYS C CB  1 
ATOM   6567 C  CG  . LYS C 1 282 ? -56.27  7.053   19.485  1    69.57  ? 278 LYS C CG  1 
ATOM   6568 C  CD  . LYS C 1 282 ? -56.726 5.605   19.352  1    71.98  ? 278 LYS C CD  1 
ATOM   6569 C  CE  . LYS C 1 282 ? -55.885 4.591   20.074  1    71.15  ? 278 LYS C CE  1 
ATOM   6570 N  NZ  . LYS C 1 282 ? -56.101 3.214   19.589  1    72.95  ? 278 LYS C NZ  1 
ATOM   6571 N  N   . ALA C 1 283 ? -58.688 9.868   21.263  1    66.82  ? 279 ALA C N   1 
ATOM   6572 C  CA  . ALA C 1 283 ? -59.862 10.667  20.944  1    69.22  ? 279 ALA C CA  1 
ATOM   6573 C  C   . ALA C 1 283 ? -59.494 12.146  20.812  1    70.8   ? 279 ALA C C   1 
ATOM   6574 O  O   . ALA C 1 283 ? -59.91  12.805  19.864  1    72.75  ? 279 ALA C O   1 
ATOM   6575 C  CB  . ALA C 1 283 ? -60.918 10.465  22.014  1    70.54  ? 279 ALA C CB  1 
ATOM   6576 N  N   . ALA C 1 284 ? -58.737 12.668  21.789  1    67.98  ? 280 ALA C N   1 
ATOM   6577 C  CA  . ALA C 1 284 ? -58.383 14.076  21.834  1    67.47  ? 280 ALA C CA  1 
ATOM   6578 C  C   . ALA C 1 284 ? -57.704 14.522  20.546  1    67.36  ? 280 ALA C C   1 
ATOM   6579 O  O   . ALA C 1 284 ? -57.852 15.669  20.16   1    70.64  ? 280 ALA C O   1 
ATOM   6580 C  CB  . ALA C 1 284 ? -57.51  14.381  23.026  1    66.43  ? 280 ALA C CB  1 
ATOM   6581 N  N   . LEU C 1 285 ? -56.969 13.619  19.891  1    67.24  ? 281 LEU C N   1 
ATOM   6582 C  CA  . LEU C 1 285 ? -56.261 13.928  18.653  1    66.36  ? 281 LEU C CA  1 
ATOM   6583 C  C   . LEU C 1 285 ? -57.23  14.201  17.504  1    67.52  ? 281 LEU C C   1 
ATOM   6584 O  O   . LEU C 1 285 ? -56.863 14.862  16.54   1    70.27  ? 281 LEU C O   1 
ATOM   6585 C  CB  . LEU C 1 285 ? -55.303 12.798  18.286  1    65.98  ? 281 LEU C CB  1 
ATOM   6586 C  CG  . LEU C 1 285 ? -54.043 12.676  19.145  1    64.81  ? 281 LEU C CG  1 
ATOM   6587 C  CD1 . LEU C 1 285 ? -53.385 11.319  18.933  1    65.23  ? 281 LEU C CD1 1 
ATOM   6588 C  CD2 . LEU C 1 285 ? -53.063 13.799  18.86   1    58.68  ? 281 LEU C CD2 1 
ATOM   6589 N  N   . ALA C 1 286 ? -58.445 13.663  17.599  1    67.47  ? 282 ALA C N   1 
ATOM   6590 C  CA  . ALA C 1 286 ? -59.497 13.933  16.631  1    73.52  ? 282 ALA C CA  1 
ATOM   6591 C  C   . ALA C 1 286 ? -60.213 15.261  16.925  1    75.63  ? 282 ALA C C   1 
ATOM   6592 O  O   . ALA C 1 286 ? -60.791 15.847  16.018  1    76.74  ? 282 ALA C O   1 
ATOM   6593 C  CB  . ALA C 1 286 ? -60.474 12.765  16.571  1    73     ? 282 ALA C CB  1 
ATOM   6594 N  N   . HIS C 1 287 ? -60.171 15.746  18.178  1    72.58  ? 283 HIS C N   1 
ATOM   6595 C  CA  . HIS C 1 287 ? -60.942 16.922  18.569  1    72.79  ? 283 HIS C CA  1 
ATOM   6596 C  C   . HIS C 1 287 ? -60.785 18.094  17.59   1    75.15  ? 283 HIS C C   1 
ATOM   6597 O  O   . HIS C 1 287 ? -59.673 18.414  17.176  1    74.44  ? 283 HIS C O   1 
ATOM   6598 C  CB  . HIS C 1 287 ? -60.655 17.321  20.019  1    66.98  ? 283 HIS C CB  1 
ATOM   6599 C  CG  . HIS C 1 287 ? -61.596 18.325  20.573  1    66.34  ? 283 HIS C CG  1 
ATOM   6600 N  ND1 . HIS C 1 287 ? -61.61  19.638  20.148  1    68.46  ? 283 HIS C ND1 1 
ATOM   6601 C  CD2 . HIS C 1 287 ? -62.549 18.215  21.508  1    66.92  ? 283 HIS C CD2 1 
ATOM   6602 C  CE1 . HIS C 1 287 ? -62.548 20.308  20.821  1    70.9   ? 283 HIS C CE1 1 
ATOM   6603 N  NE2 . HIS C 1 287 ? -63.134 19.461  21.652  1    70.67  ? 283 HIS C NE2 1 
ATOM   6604 N  N   . PRO C 1 288 ? -61.909 18.748  17.202  1    78.87  ? 284 PRO C N   1 
ATOM   6605 C  CA  . PRO C 1 288 ? -61.927 19.926  16.315  1    80.88  ? 284 PRO C CA  1 
ATOM   6606 C  C   . PRO C 1 288 ? -60.937 21.071  16.523  1    79.82  ? 284 PRO C C   1 
ATOM   6607 O  O   . PRO C 1 288 ? -60.685 21.844  15.593  1    83.12  ? 284 PRO C O   1 
ATOM   6608 C  CB  . PRO C 1 288 ? -63.387 20.452  16.44   1    81.24  ? 284 PRO C CB  1 
ATOM   6609 C  CG  . PRO C 1 288 ? -63.963 19.719  17.639  1    81.46  ? 284 PRO C CG  1 
ATOM   6610 C  CD  . PRO C 1 288 ? -63.275 18.361  17.602  1    81.63  ? 284 PRO C CD  1 
ATOM   6611 N  N   . PHE C 1 289 ? -60.434 21.21   17.758  1    75.86  ? 285 PHE C N   1 
ATOM   6612 C  CA  . PHE C 1 289 ? -59.498 22.273  18.096  1    75.58  ? 285 PHE C CA  1 
ATOM   6613 C  C   . PHE C 1 289 ? -58.204 22.117  17.292  1    76.76  ? 285 PHE C C   1 
ATOM   6614 O  O   . PHE C 1 289 ? -57.448 23.081  17.163  1    75.54  ? 285 PHE C O   1 
ATOM   6615 C  CB  . PHE C 1 289 ? -59.338 22.323  19.622  1    71.71  ? 285 PHE C CB  1 
ATOM   6616 C  CG  . PHE C 1 289 ? -58.168 23.114  20.189  1    68.85  ? 285 PHE C CG  1 
ATOM   6617 C  CD1 . PHE C 1 289 ? -58.23  24.49   20.346  1    70.78  ? 285 PHE C CD1 1 
ATOM   6618 C  CD2 . PHE C 1 289 ? -57.011 22.459  20.591  1    66.36  ? 285 PHE C CD2 1 
ATOM   6619 C  CE1 . PHE C 1 289 ? -57.17  25.194  20.899  1    69.18  ? 285 PHE C CE1 1 
ATOM   6620 C  CE2 . PHE C 1 289 ? -55.943 23.156  21.12   1    64.95  ? 285 PHE C CE2 1 
ATOM   6621 C  CZ  . PHE C 1 289 ? -56.03  24.522  21.277  1    67.8   ? 285 PHE C CZ  1 
ATOM   6622 N  N   . PHE C 1 290 ? -57.975 20.916  16.729  1    77.32  ? 286 PHE C N   1 
ATOM   6623 C  CA  . PHE C 1 290 ? -56.713 20.58   16.08   1    75.21  ? 286 PHE C CA  1 
ATOM   6624 C  C   . PHE C 1 290 ? -56.838 20.578  14.556  1    81.72  ? 286 PHE C C   1 
ATOM   6625 O  O   . PHE C 1 290 ? -55.835 20.428  13.865  1    83.1   ? 286 PHE C O   1 
ATOM   6626 C  CB  . PHE C 1 290 ? -56.19  19.228  16.567  1    69.1   ? 286 PHE C CB  1 
ATOM   6627 C  CG  . PHE C 1 290 ? -55.627 19.282  17.977  1    64.16  ? 286 PHE C CG  1 
ATOM   6628 C  CD1 . PHE C 1 290 ? -54.66  20.221  18.315  1    61.69  ? 286 PHE C CD1 1 
ATOM   6629 C  CD2 . PHE C 1 290 ? -56.086 18.408  18.96   1    60.6   ? 286 PHE C CD2 1 
ATOM   6630 C  CE1 . PHE C 1 290 ? -54.168 20.269  19.608  1    61.31  ? 286 PHE C CE1 1 
ATOM   6631 C  CE2 . PHE C 1 290 ? -55.611 18.477  20.254  1    57.53  ? 286 PHE C CE2 1 
ATOM   6632 C  CZ  . PHE C 1 290 ? -54.654 19.408  20.576  1    59.1   ? 286 PHE C CZ  1 
ATOM   6633 N  N   . GLN C 1 291 ? -58.052 20.774  14.028  1    85.72  ? 287 GLN C N   1 
ATOM   6634 C  CA  . GLN C 1 291 ? -58.287 20.68   12.592  1    92.82  ? 287 GLN C CA  1 
ATOM   6635 C  C   . GLN C 1 291 ? -57.267 21.52   11.813  1    89.33  ? 287 GLN C C   1 
ATOM   6636 O  O   . GLN C 1 291 ? -56.923 21.195  10.678  1    88.41  ? 287 GLN C O   1 
ATOM   6637 C  CB  . GLN C 1 291 ? -59.736 21.046  12.251  1    99.18  ? 287 GLN C CB  1 
ATOM   6638 C  CG  . GLN C 1 291 ? -59.993 22.55   12.205  1    115.74 ? 287 GLN C CG  1 
ATOM   6639 C  CD  . GLN C 1 291 ? -61.388 22.977  12.615  1    128.16 ? 287 GLN C CD  1 
ATOM   6640 O  OE1 . GLN C 1 291 ? -61.72  24.168  12.614  1    126.35 ? 287 GLN C OE1 1 
ATOM   6641 N  NE2 . GLN C 1 291 ? -62.225 22.017  12.984  1    138.41 ? 287 GLN C NE2 1 
ATOM   6642 N  N   . ASP C 1 292 ? -56.778 22.599  12.431  1    85.26  ? 288 ASP C N   1 
ATOM   6643 C  CA  . ASP C 1 292 ? -56.009 23.597  11.71   1    88.98  ? 288 ASP C CA  1 
ATOM   6644 C  C   . ASP C 1 292 ? -54.621 23.729  12.335  1    84.09  ? 288 ASP C C   1 
ATOM   6645 O  O   . ASP C 1 292 ? -53.976 24.776  12.203  1    81.37  ? 288 ASP C O   1 
ATOM   6646 C  CB  . ASP C 1 292 ? -56.768 24.918  11.688  1    100.04 ? 288 ASP C CB  1 
ATOM   6647 C  CG  . ASP C 1 292 ? -56.755 25.7    12.999  1    104.78 ? 288 ASP C CG  1 
ATOM   6648 O  OD1 . ASP C 1 292 ? -56.818 25.08   14.101  1    97.06  ? 288 ASP C OD1 1 
ATOM   6649 O  OD2 . ASP C 1 292 ? -56.668 26.934  12.905  1    106.28 ? 288 ASP C OD2 1 
ATOM   6650 N  N   . VAL C 1 293 ? -54.155 22.649  12.984  1    79.91  ? 289 VAL C N   1 
ATOM   6651 C  CA  . VAL C 1 293 ? -52.884 22.682  13.689  1    75.5   ? 289 VAL C CA  1 
ATOM   6652 C  C   . VAL C 1 293 ? -51.752 22.834  12.67   1    80.16  ? 289 VAL C C   1 
ATOM   6653 O  O   . VAL C 1 293 ? -51.772 22.227  11.598  1    80.68  ? 289 VAL C O   1 
ATOM   6654 C  CB  . VAL C 1 293 ? -52.672 21.487  14.637  1    70.2   ? 289 VAL C CB  1 
ATOM   6655 C  CG1 . VAL C 1 293 ? -52.467 20.179  13.89   1    68.71  ? 289 VAL C CG1 1 
ATOM   6656 C  CG2 . VAL C 1 293 ? -51.513 21.727  15.596  1    63.62  ? 289 VAL C CG2 1 
ATOM   6657 N  N   . THR C 1 294 ? -50.786 23.694  13.02   1    84.46  ? 290 THR C N   1 
ATOM   6658 C  CA  . THR C 1 294 ? -49.528 23.86   12.3    1    82.07  ? 290 THR C CA  1 
ATOM   6659 C  C   . THR C 1 294 ? -48.403 23.477  13.255  1    83.06  ? 290 THR C C   1 
ATOM   6660 O  O   . THR C 1 294 ? -48.662 22.892  14.303  1    86.61  ? 290 THR C O   1 
ATOM   6661 C  CB  . THR C 1 294 ? -49.379 25.295  11.788  1    83.11  ? 290 THR C CB  1 
ATOM   6662 O  OG1 . THR C 1 294 ? -49.225 26.137  12.938  1    81.05  ? 290 THR C OG1 1 
ATOM   6663 C  CG2 . THR C 1 294 ? -50.54  25.717  10.898  1    79.72  ? 290 THR C CG2 1 
ATOM   6664 N  N   . LYS C 1 295 ? -47.158 23.82   12.899  1    83.65  ? 291 LYS C N   1 
ATOM   6665 C  CA  . LYS C 1 295 ? -46.005 23.58   13.755  1    78.24  ? 291 LYS C CA  1 
ATOM   6666 C  C   . LYS C 1 295 ? -45.108 24.82   13.787  1    77.82  ? 291 LYS C C   1 
ATOM   6667 O  O   . LYS C 1 295 ? -44.053 24.832  13.154  1    80.16  ? 291 LYS C O   1 
ATOM   6668 C  CB  . LYS C 1 295 ? -45.215 22.358  13.273  1    72.19  ? 291 LYS C CB  1 
ATOM   6669 C  CG  . LYS C 1 295 ? -44.278 21.786  14.334  1    69.14  ? 291 LYS C CG  1 
ATOM   6670 C  CD  . LYS C 1 295 ? -43.161 20.872  13.856  1    71.28  ? 291 LYS C CD  1 
ATOM   6671 C  CE  . LYS C 1 295 ? -42.57  20.058  14.957  1    78.76  ? 291 LYS C CE  1 
ATOM   6672 N  NZ  . LYS C 1 295 ? -41.192 19.629  14.683  1    80.2   ? 291 LYS C NZ  1 
ATOM   6673 N  N   . PRO C 1 296 ? -45.48  25.898  14.518  1    75.66  ? 292 PRO C N   1 
ATOM   6674 C  CA  . PRO C 1 296 ? -44.631 27.092  14.632  1    76.44  ? 292 PRO C CA  1 
ATOM   6675 C  C   . PRO C 1 296 ? -43.36  26.872  15.451  1    78.44  ? 292 PRO C C   1 
ATOM   6676 O  O   . PRO C 1 296 ? -43.348 26.08   16.394  1    80.9   ? 292 PRO C O   1 
ATOM   6677 C  CB  . PRO C 1 296 ? -45.516 28.173  15.296  1    72.7   ? 292 PRO C CB  1 
ATOM   6678 C  CG  . PRO C 1 296 ? -46.867 27.518  15.551  1    73.52  ? 292 PRO C CG  1 
ATOM   6679 C  CD  . PRO C 1 296 ? -46.739 26.025  15.274  1    77.23  ? 292 PRO C CD  1 
ATOM   6680 N  N   . VAL C 1 297 ? -42.305 27.616  15.113  1    78.49  ? 293 VAL C N   1 
ATOM   6681 C  CA  . VAL C 1 297 ? -41.075 27.573  15.886  1    79.8   ? 293 VAL C CA  1 
ATOM   6682 C  C   . VAL C 1 297 ? -41.208 28.534  17.068  1    80.74  ? 293 VAL C C   1 
ATOM   6683 O  O   . VAL C 1 297 ? -41.819 29.585  16.943  1    82.62  ? 293 VAL C O   1 
ATOM   6684 C  CB  . VAL C 1 297 ? -39.835 27.832  15.002  1    80.16  ? 293 VAL C CB  1 
ATOM   6685 C  CG1 . VAL C 1 297 ? -39.906 27.021  13.712  1    82.72  ? 293 VAL C CG1 1 
ATOM   6686 C  CG2 . VAL C 1 297 ? -39.601 29.304  14.692  1    77.83  ? 293 VAL C CG2 1 
ATOM   6687 N  N   . PRO C 1 298 ? -40.696 28.213  18.279  1    84.69  ? 294 PRO C N   1 
ATOM   6688 C  CA  . PRO C 1 298 ? -40.863 29.113  19.43   1    81.64  ? 294 PRO C CA  1 
ATOM   6689 C  C   . PRO C 1 298 ? -39.823 30.221  19.333  1    93.63  ? 294 PRO C C   1 
ATOM   6690 O  O   . PRO C 1 298 ? -38.841 30.083  18.606  1    103.07 ? 294 PRO C O   1 
ATOM   6691 C  CB  . PRO C 1 298 ? -40.567 28.172  20.581  1    79.29  ? 294 PRO C CB  1 
ATOM   6692 C  CG  . PRO C 1 298 ? -39.47  27.296  20.023  1    82.2   ? 294 PRO C CG  1 
ATOM   6693 C  CD  . PRO C 1 298 ? -39.914 27.002  18.595  1    78.26  ? 294 PRO C CD  1 
ATOM   6694 N  N   . HIS C 1 299 ? -40.031 31.31   20.075  1    106.77 ? 295 HIS C N   1 
ATOM   6695 C  CA  . HIS C 1 299 ? -39.077 32.406  20.099  1    118.35 ? 295 HIS C CA  1 
ATOM   6696 C  C   . HIS C 1 299 ? -38.07  32.131  21.215  1    125.27 ? 295 HIS C C   1 
ATOM   6697 O  O   . HIS C 1 299 ? -38.389 32.262  22.395  1    138.14 ? 295 HIS C O   1 
ATOM   6698 C  CB  . HIS C 1 299 ? -39.833 33.74   20.172  1    124.73 ? 295 HIS C CB  1 
ATOM   6699 C  CG  . HIS C 1 299 ? -38.992 34.951  19.957  1    134.58 ? 295 HIS C CG  1 
ATOM   6700 N  ND1 . HIS C 1 299 ? -38.381 35.257  18.757  1    141.03 ? 295 HIS C ND1 1 
ATOM   6701 C  CD2 . HIS C 1 299 ? -38.654 35.932  20.805  1    133.9  ? 295 HIS C CD2 1 
ATOM   6702 C  CE1 . HIS C 1 299 ? -37.7   36.388  18.886  1    140.19 ? 295 HIS C CE1 1 
ATOM   6703 N  NE2 . HIS C 1 299 ? -37.859 36.818  20.12   1    141.77 ? 295 HIS C NE2 1 
ATOM   6704 N  N   . LEU C 1 300 ? -36.865 31.712  20.821  1    122.31 ? 296 LEU C N   1 
ATOM   6705 C  CA  . LEU C 1 300 ? -35.842 31.339  21.782  1    117.86 ? 296 LEU C CA  1 
ATOM   6706 C  C   . LEU C 1 300 ? -34.63  32.25   21.538  1    111.87 ? 296 LEU C C   1 
ATOM   6707 O  O   . LEU C 1 300 ? -34.149 32.825  22.529  1    104.16 ? 296 LEU C O   1 
ATOM   6708 C  CB  . LEU C 1 300 ? -35.476 29.854  21.697  1    108.22 ? 296 LEU C CB  1 
ATOM   6709 C  CG  . LEU C 1 300 ? -36.559 28.833  22.065  1    101.83 ? 296 LEU C CG  1 
ATOM   6710 C  CD1 . LEU C 1 300 ? -36.139 27.417  21.604  1    89.71  ? 296 LEU C CD1 1 
ATOM   6711 C  CD2 . LEU C 1 300 ? -36.879 28.854  23.559  1    102.04 ? 296 LEU C CD2 1 
ATOM   6712 N  N   . GLY D 2 1   ? -64.918 0.395   31.782  1    84.29  ? 171 GLY D N   1 
ATOM   6713 C  CA  . GLY D 2 1   ? -64.215 1.526   32.417  1    84.66  ? 171 GLY D CA  1 
ATOM   6714 C  C   . GLY D 2 1   ? -62.834 1.765   31.796  1    82.81  ? 171 GLY D C   1 
ATOM   6715 O  O   . GLY D 2 1   ? -62.269 0.896   31.106  1    77.94  ? 171 GLY D O   1 
ATOM   6716 N  N   . VAL D 2 2   ? -62.309 2.967   32.084  1    79.77  ? 172 VAL D N   1 
ATOM   6717 C  CA  . VAL D 2 2   ? -60.99  3.374   31.642  1    76.34  ? 172 VAL D CA  1 
ATOM   6718 C  C   . VAL D 2 2   ? -59.974 2.381   32.208  1    75.97  ? 172 VAL D C   1 
ATOM   6719 O  O   . VAL D 2 2   ? -58.916 2.178   31.615  1    75.87  ? 172 VAL D O   1 
ATOM   6720 C  CB  . VAL D 2 2   ? -60.661 4.831   32.012  1    75.18  ? 172 VAL D CB  1 
ATOM   6721 C  CG1 . VAL D 2 2   ? -60.29  5.001   33.489  1    72.25  ? 172 VAL D CG1 1 
ATOM   6722 C  CG2 . VAL D 2 2   ? -59.599 5.409   31.081  1    71.21  ? 172 VAL D CG2 1 
ATOM   6723 N  N   . ASN D 2 3   ? -60.346 1.733   33.324  1    74.44  ? 173 ASN D N   1 
ATOM   6724 C  CA  . ASN D 2 3   ? -59.569 0.669   33.944  1    74.58  ? 173 ASN D CA  1 
ATOM   6725 C  C   . ASN D 2 3   ? -59.291 -0.47   32.958  1    71.51  ? 173 ASN D C   1 
ATOM   6726 O  O   . ASN D 2 3   ? -58.341 -1.231  33.14   1    69.84  ? 173 ASN D O   1 
ATOM   6727 C  CB  . ASN D 2 3   ? -60.212 0.231   35.254  1    77.93  ? 173 ASN D CB  1 
ATOM   6728 C  CG  . ASN D 2 3   ? -60.172 1.328   36.292  1    80.5   ? 173 ASN D CG  1 
ATOM   6729 O  OD1 . ASN D 2 3   ? -59.287 2.186   36.261  1    81.9   ? 173 ASN D OD1 1 
ATOM   6730 N  ND2 . ASN D 2 3   ? -61.103 1.321   37.232  1    85.52  ? 173 ASN D ND2 1 
ATOM   6731 N  N   . GLU D 2 4   ? -60.115 -0.575  31.91   1    74.89  ? 174 GLU D N   1 
ATOM   6732 C  CA  . GLU D 2 4   ? -59.99  -1.62   30.9    1    78.48  ? 174 GLU D CA  1 
ATOM   6733 C  C   . GLU D 2 4   ? -59.468 -1.03   29.587  1    77.66  ? 174 GLU D C   1 
ATOM   6734 O  O   . GLU D 2 4   ? -59.524 -1.678  28.54   1    75.54  ? 174 GLU D O   1 
ATOM   6735 C  CB  . GLU D 2 4   ? -61.341 -2.322  30.707  1    81.63  ? 174 GLU D CB  1 
ATOM   6736 C  CG  . GLU D 2 4   ? -61.891 -3.005  31.962  1    82.82  ? 174 GLU D CG  1 
ATOM   6737 C  CD  . GLU D 2 4   ? -63.285 -3.591  31.861  1    89.79  ? 174 GLU D CD  1 
ATOM   6738 O  OE1 . GLU D 2 4   ? -63.977 -3.378  30.837  1    91.3   ? 174 GLU D OE1 1 
ATOM   6739 O  OE2 . GLU D 2 4   ? -63.676 -4.284  32.822  1    92.13  ? 174 GLU D OE2 1 
ATOM   6740 N  N   . VAL D 2 5   ? -58.955 0.207   29.661  1    76.15  ? 175 VAL D N   1 
ATOM   6741 C  CA  . VAL D 2 5   ? -58.482 1.01    28.533  1    74.12  ? 175 VAL D CA  1 
ATOM   6742 C  C   . VAL D 2 5   ? -59.173 0.66    27.209  1    76.81  ? 175 VAL D C   1 
ATOM   6743 O  O   . VAL D 2 5   ? -58.542 0.104   26.303  1    73.08  ? 175 VAL D O   1 
ATOM   6744 C  CB  . VAL D 2 5   ? -56.949 0.959   28.421  1    65.28  ? 175 VAL D CB  1 
ATOM   6745 C  CG1 . VAL D 2 5   ? -56.302 1.675   29.593  1    60.02  ? 175 VAL D CG1 1 
ATOM   6746 C  CG2 . VAL D 2 5   ? -56.434 -0.456  28.25   1    61.85  ? 175 VAL D CG2 1 
ATOM   6747 N  N   . PRO D 2 6   ? -60.488 0.961   27.069  1    81.3   ? 176 PRO D N   1 
ATOM   6748 C  CA  . PRO D 2 6   ? -61.219 0.778   25.809  1    82.06  ? 176 PRO D CA  1 
ATOM   6749 C  C   . PRO D 2 6   ? -60.535 1.253   24.532  1    80.58  ? 176 PRO D C   1 
ATOM   6750 O  O   . PRO D 2 6   ? -60.544 0.536   23.54   1    84.67  ? 176 PRO D O   1 
ATOM   6751 C  CB  . PRO D 2 6   ? -62.577 1.495   26.007  1    83.37  ? 176 PRO D CB  1 
ATOM   6752 C  CG  . PRO D 2 6   ? -62.483 2.155   27.384  1    85.59  ? 176 PRO D CG  1 
ATOM   6753 C  CD  . PRO D 2 6   ? -61.372 1.437   28.15   1    83.12  ? 176 PRO D CD  1 
ATOM   6754 N  N   . ASP D 2 7   ? -60.001 2.479   24.538  1    79.83  ? 177 ASP D N   1 
ATOM   6755 C  CA  . ASP D 2 7   ? -59.472 3.064   23.311  1    81.06  ? 177 ASP D CA  1 
ATOM   6756 C  C   . ASP D 2 7   ? -58.09  2.508   22.966  1    77.65  ? 177 ASP D C   1 
ATOM   6757 O  O   . ASP D 2 7   ? -57.549 2.882   21.934  1    80.65  ? 177 ASP D O   1 
ATOM   6758 C  CB  . ASP D 2 7   ? -59.473 4.585   23.338  1    83.55  ? 177 ASP D CB  1 
ATOM   6759 C  CG  . ASP D 2 7   ? -60.854 5.223   23.383  1    90.24  ? 177 ASP D CG  1 
ATOM   6760 O  OD1 . ASP D 2 7   ? -61.841 4.446   23.432  1    97.58  ? 177 ASP D OD1 1 
ATOM   6761 O  OD2 . ASP D 2 7   ? -60.94  6.479   23.358  1    87.64  ? 177 ASP D OD2 1 
ATOM   6762 N  N   . TYR D 2 8   ? -57.525 1.62    23.802  1    73.84  ? 178 TYR D N   1 
ATOM   6763 C  CA  . TYR D 2 8   ? -56.17  1.12    23.602  1    71.44  ? 178 TYR D CA  1 
ATOM   6764 C  C   . TYR D 2 8   ? -56.053 -0.405  23.659  1    75.38  ? 178 TYR D C   1 
ATOM   6765 O  O   . TYR D 2 8   ? -55.057 -0.914  23.169  1    75.33  ? 178 TYR D O   1 
ATOM   6766 C  CB  . TYR D 2 8   ? -55.17  1.687   24.617  1    64.67  ? 178 TYR D CB  1 
ATOM   6767 C  CG  . TYR D 2 8   ? -55.102 3.201   24.573  1    61.56  ? 178 TYR D CG  1 
ATOM   6768 C  CD1 . TYR D 2 8   ? -54.55  3.877   23.489  1    60.57  ? 178 TYR D CD1 1 
ATOM   6769 C  CD2 . TYR D 2 8   ? -55.647 3.943   25.607  1    62.83  ? 178 TYR D CD2 1 
ATOM   6770 C  CE1 . TYR D 2 8   ? -54.528 5.261   23.445  1    63.32  ? 178 TYR D CE1 1 
ATOM   6771 C  CE2 . TYR D 2 8   ? -55.616 5.33    25.585  1    66.04  ? 178 TYR D CE2 1 
ATOM   6772 C  CZ  . TYR D 2 8   ? -55.058 5.99    24.503  1    65.64  ? 178 TYR D CZ  1 
ATOM   6773 O  OH  . TYR D 2 8   ? -55.059 7.353   24.565  1    68.68  ? 178 TYR D OH  1 
ATOM   6774 N  N   . HIS D 2 9   ? -57.026 -1.128  24.246  1    81.1   ? 179 HIS D N   1 
ATOM   6775 C  CA  . HIS D 2 9   ? -56.88  -2.557  24.523  1    80.82  ? 179 HIS D CA  1 
ATOM   6776 C  C   . HIS D 2 9   ? -56.394 -3.337  23.299  1    78.32  ? 179 HIS D C   1 
ATOM   6777 O  O   . HIS D 2 9   ? -55.637 -4.301  23.452  1    78.3   ? 179 HIS D O   1 
ATOM   6778 C  CB  . HIS D 2 9   ? -58.12  -3.176  25.188  1    87.23  ? 179 HIS D CB  1 
ATOM   6779 C  CG  . HIS D 2 9   ? -59.236 -3.526  24.257  1    102.86 ? 179 HIS D CG  1 
ATOM   6780 N  ND1 . HIS D 2 9   ? -60.405 -2.793  24.194  1    107.39 ? 179 HIS D ND1 1 
ATOM   6781 C  CD2 . HIS D 2 9   ? -59.373 -4.534  23.361  1    109.63 ? 179 HIS D CD2 1 
ATOM   6782 C  CE1 . HIS D 2 9   ? -61.208 -3.339  23.28   1    112.95 ? 179 HIS D CE1 1 
ATOM   6783 N  NE2 . HIS D 2 9   ? -60.601 -4.393  22.761  1    109.68 ? 179 HIS D NE2 1 
ATOM   6784 N  N   . GLU D 2 10  ? -56.812 -2.903  22.1    1    75.78  ? 180 GLU D N   1 
ATOM   6785 C  CA  . GLU D 2 10  ? -56.456 -3.619  20.889  1    78.08  ? 180 GLU D CA  1 
ATOM   6786 C  C   . GLU D 2 10  ? -55.03  -3.306  20.459  1    73.66  ? 180 GLU D C   1 
ATOM   6787 O  O   . GLU D 2 10  ? -54.275 -4.211  20.099  1    72.99  ? 180 GLU D O   1 
ATOM   6788 C  CB  . GLU D 2 10  ? -57.406 -3.337  19.732  1    86.93  ? 180 GLU D CB  1 
ATOM   6789 C  CG  . GLU D 2 10  ? -58.738 -4.066  19.901  1    97.9   ? 180 GLU D CG  1 
ATOM   6790 C  CD  . GLU D 2 10  ? -59.427 -4.291  18.562  1    103.88 ? 180 GLU D CD  1 
ATOM   6791 O  OE1 . GLU D 2 10  ? -59.264 -3.409  17.669  1    99.6   ? 180 GLU D OE1 1 
ATOM   6792 O  OE2 . GLU D 2 10  ? -60.128 -5.336  18.442  1    104.74 ? 180 GLU D OE2 1 
ATOM   6793 N  N   . ASP D 2 11  ? -54.694 -2.014  20.45   1    71.31  ? 181 ASP D N   1 
ATOM   6794 C  CA  . ASP D 2 11  ? -53.323 -1.584  20.205  1    69.4   ? 181 ASP D CA  1 
ATOM   6795 C  C   . ASP D 2 11  ? -52.361 -2.326  21.139  1    64.38  ? 181 ASP D C   1 
ATOM   6796 O  O   . ASP D 2 11  ? -51.304 -2.776  20.711  1    65.41  ? 181 ASP D O   1 
ATOM   6797 C  CB  . ASP D 2 11  ? -53.179 -0.074  20.323  1    69.52  ? 181 ASP D CB  1 
ATOM   6798 C  CG  . ASP D 2 11  ? -53.927 0.738   19.275  1    72.69  ? 181 ASP D CG  1 
ATOM   6799 O  OD1 . ASP D 2 11  ? -54.538 0.12    18.395  1    72.76  ? 181 ASP D OD1 1 
ATOM   6800 O  OD2 . ASP D 2 11  ? -53.855 1.987   19.317  1    73.65  ? 181 ASP D OD2 1 
ATOM   6801 N  N   . ILE D 2 12  ? -52.762 -2.489  22.401  1    60.49  ? 182 ILE D N   1 
ATOM   6802 C  CA  . ILE D 2 12  ? -51.916 -3.079  23.419  1    61.7   ? 182 ILE D CA  1 
ATOM   6803 C  C   . ILE D 2 12  ? -51.747 -4.578  23.173  1    64.51  ? 182 ILE D C   1 
ATOM   6804 O  O   . ILE D 2 12  ? -50.634 -5.099  23.32   1    64.81  ? 182 ILE D O   1 
ATOM   6805 C  CB  . ILE D 2 12  ? -52.44  -2.777  24.835  1    59.08  ? 182 ILE D CB  1 
ATOM   6806 C  CG1 . ILE D 2 12  ? -52.285 -1.307  25.213  1    55.91  ? 182 ILE D CG1 1 
ATOM   6807 C  CG2 . ILE D 2 12  ? -51.738 -3.672  25.853  1    58.93  ? 182 ILE D CG2 1 
ATOM   6808 C  CD1 . ILE D 2 12  ? -53.083 -0.901  26.438  1    54.78  ? 182 ILE D CD1 1 
ATOM   6809 N  N   . HIS D 2 13  ? -52.854 -5.26   22.83   1    67.03  ? 183 HIS D N   1 
ATOM   6810 C  CA  . HIS D 2 13  ? -52.822 -6.68   22.513  1    64.51  ? 183 HIS D CA  1 
ATOM   6811 C  C   . HIS D 2 13  ? -51.886 -6.925  21.324  1    66.9   ? 183 HIS D C   1 
ATOM   6812 O  O   . HIS D 2 13  ? -51.051 -7.83   21.373  1    66.16  ? 183 HIS D O   1 
ATOM   6813 C  CB  . HIS D 2 13  ? -54.228 -7.219  22.227  1    68.03  ? 183 HIS D CB  1 
ATOM   6814 C  CG  . HIS D 2 13  ? -54.229 -8.637  21.735  1    68.23  ? 183 HIS D CG  1 
ATOM   6815 N  ND1 . HIS D 2 13  ? -54.301 -9.691  22.629  1    69.08  ? 183 HIS D ND1 1 
ATOM   6816 C  CD2 . HIS D 2 13  ? -54.123 -9.18   20.505  1    65.32  ? 183 HIS D CD2 1 
ATOM   6817 C  CE1 . HIS D 2 13  ? -54.259 -10.83  21.959  1    67.74  ? 183 HIS D CE1 1 
ATOM   6818 N  NE2 . HIS D 2 13  ? -54.134 -10.547 20.674  1    68.22  ? 183 HIS D NE2 1 
ATOM   6819 N  N   . THR D 2 14  ? -52.045 -6.127  20.252  1    64.63  ? 184 THR D N   1 
ATOM   6820 C  CA  . THR D 2 14  ? -51.245 -6.297  19.053  1    64.53  ? 184 THR D CA  1 
ATOM   6821 C  C   . THR D 2 14  ? -49.77  -6.164  19.415  1    63.29  ? 184 THR D C   1 
ATOM   6822 O  O   . THR D 2 14  ? -48.941 -6.926  18.91   1    65.26  ? 184 THR D O   1 
ATOM   6823 C  CB  . THR D 2 14  ? -51.686 -5.326  17.947  1    67.61  ? 184 THR D CB  1 
ATOM   6824 O  OG1 . THR D 2 14  ? -53.022 -5.67   17.576  1    72.56  ? 184 THR D OG1 1 
ATOM   6825 C  CG2 . THR D 2 14  ? -50.866 -5.433  16.672  1    63.59  ? 184 THR D CG2 1 
ATOM   6826 N  N   . TYR D 2 15  ? -49.459 -5.164  20.25   1    62.03  ? 185 TYR D N   1 
ATOM   6827 C  CA  . TYR D 2 15  ? -48.088 -4.862  20.638  1    59.31  ? 185 TYR D CA  1 
ATOM   6828 C  C   . TYR D 2 15  ? -47.525 -6.037  21.428  1    56.67  ? 185 TYR D C   1 
ATOM   6829 O  O   . TYR D 2 15  ? -46.447 -6.515  21.105  1    60.37  ? 185 TYR D O   1 
ATOM   6830 C  CB  . TYR D 2 15  ? -47.983 -3.543  21.414  1    58.05  ? 185 TYR D CB  1 
ATOM   6831 C  CG  . TYR D 2 15  ? -46.566 -3.14   21.788  1    59.64  ? 185 TYR D CG  1 
ATOM   6832 C  CD1 . TYR D 2 15  ? -45.588 -2.954  20.81   1    61.72  ? 185 TYR D CD1 1 
ATOM   6833 C  CD2 . TYR D 2 15  ? -46.188 -3.003  23.131  1    56.43  ? 185 TYR D CD2 1 
ATOM   6834 C  CE1 . TYR D 2 15  ? -44.289 -2.605  21.169  1    63.91  ? 185 TYR D CE1 1 
ATOM   6835 C  CE2 . TYR D 2 15  ? -44.895 -2.657  23.497  1    53.66  ? 185 TYR D CE2 1 
ATOM   6836 C  CZ  . TYR D 2 15  ? -43.941 -2.457  22.512  1    58.86  ? 185 TYR D CZ  1 
ATOM   6837 O  OH  . TYR D 2 15  ? -42.661 -2.1    22.834  1    55.88  ? 185 TYR D OH  1 
ATOM   6838 N  N   . LEU D 2 16  ? -48.266 -6.511  22.439  1    53.89  ? 186 LEU D N   1 
ATOM   6839 C  CA  . LEU D 2 16  ? -47.824 -7.61   23.281  1    51.47  ? 186 LEU D CA  1 
ATOM   6840 C  C   . LEU D 2 16  ? -47.551 -8.861  22.445  1    56.47  ? 186 LEU D C   1 
ATOM   6841 O  O   . LEU D 2 16  ? -46.62  -9.596  22.742  1    60.16  ? 186 LEU D O   1 
ATOM   6842 C  CB  . LEU D 2 16  ? -48.866 -7.891  24.357  1    50.9   ? 186 LEU D CB  1 
ATOM   6843 C  CG  . LEU D 2 16  ? -49.084 -6.785  25.396  1    54.52  ? 186 LEU D CG  1 
ATOM   6844 C  CD1 . LEU D 2 16  ? -50.307 -7.117  26.273  1    55.58  ? 186 LEU D CD1 1 
ATOM   6845 C  CD2 . LEU D 2 16  ? -47.833 -6.545  26.254  1    48.46  ? 186 LEU D CD2 1 
ATOM   6846 N  N   . ARG D 2 17  ? -48.365 -9.125  21.414  1    57.85  ? 187 ARG D N   1 
ATOM   6847 C  CA  . ARG D 2 17  ? -48.158 -10.279 20.554  1    61.22  ? 187 ARG D CA  1 
ATOM   6848 C  C   . ARG D 2 17  ? -46.793 -10.168 19.859  1    63.98  ? 187 ARG D C   1 
ATOM   6849 O  O   . ARG D 2 17  ? -46.037 -11.14  19.726  1    65.56  ? 187 ARG D O   1 
ATOM   6850 C  CB  . ARG D 2 17  ? -49.295 -10.408 19.524  1    58.96  ? 187 ARG D CB  1 
ATOM   6851 C  CG  . ARG D 2 17  ? -50.597 -10.971 20.066  1    57.26  ? 187 ARG D CG  1 
ATOM   6852 C  CD  . ARG D 2 17  ? -50.529 -12.46  20.372  1    57.84  ? 187 ARG D CD  1 
ATOM   6853 N  NE  . ARG D 2 17  ? -50.355 -13.202 19.122  1    57.23  ? 187 ARG D NE  1 
ATOM   6854 C  CZ  . ARG D 2 17  ? -51.337 -13.718 18.397  1    59.71  ? 187 ARG D CZ  1 
ATOM   6855 N  NH1 . ARG D 2 17  ? -52.578 -13.779 18.846  1    59.91  ? 187 ARG D NH1 1 
ATOM   6856 N  NH2 . ARG D 2 17  ? -51.052 -14.19  17.21   1    60.58  ? 187 ARG D NH2 1 
ATOM   6857 N  N   . GLU D 2 18  ? -46.51  -8.955  19.384  1    61.1   ? 188 GLU D N   1 
ATOM   6858 C  CA  . GLU D 2 18  ? -45.258 -8.625  18.743  1    61.62  ? 188 GLU D CA  1 
ATOM   6859 C  C   . GLU D 2 18  ? -44.104 -8.869  19.711  1    61.24  ? 188 GLU D C   1 
ATOM   6860 O  O   . GLU D 2 18  ? -43.119 -9.496  19.343  1    63.84  ? 188 GLU D O   1 
ATOM   6861 C  CB  . GLU D 2 18  ? -45.411 -7.149  18.407  1    65.48  ? 188 GLU D CB  1 
ATOM   6862 C  CG  . GLU D 2 18  ? -44.557 -6.679  17.239  1    75.66  ? 188 GLU D CG  1 
ATOM   6863 C  CD  . GLU D 2 18  ? -45.057 -5.306  16.84   1    79.99  ? 188 GLU D CD  1 
ATOM   6864 O  OE1 . GLU D 2 18  ? -46.234 -5.215  16.374  1    75.77  ? 188 GLU D OE1 1 
ATOM   6865 O  OE2 . GLU D 2 18  ? -44.254 -4.354  17.049  1    74.1   ? 188 GLU D OE2 1 
ATOM   6866 N  N   . MET D 2 19  ? -44.263 -8.416  20.958  1    59.07  ? 189 MET D N   1 
ATOM   6867 C  CA  . MET D 2 19  ? -43.198 -8.399  21.944  1    60.96  ? 189 MET D CA  1 
ATOM   6868 C  C   . MET D 2 19  ? -42.924 -9.783  22.535  1    62.45  ? 189 MET D C   1 
ATOM   6869 O  O   . MET D 2 19  ? -41.773 -10.067 22.876  1    60.42  ? 189 MET D O   1 
ATOM   6870 C  CB  . MET D 2 19  ? -43.486 -7.398  23.07   1    59.38  ? 189 MET D CB  1 
ATOM   6871 C  CG  . MET D 2 19  ? -43.469 -5.968  22.602  1    61.87  ? 189 MET D CG  1 
ATOM   6872 S  SD  . MET D 2 19  ? -41.841 -5.511  21.991  1    64.09  ? 189 MET D SD  1 
ATOM   6873 C  CE  . MET D 2 19  ? -40.905 -5.576  23.538  1    70.16  ? 189 MET D CE  1 
ATOM   6874 N  N   . GLU D 2 20  ? -43.962 -10.627 22.669  1    59.29  ? 190 GLU D N   1 
ATOM   6875 C  CA  . GLU D 2 20  ? -43.774 -11.983 23.167  1    56.55  ? 190 GLU D CA  1 
ATOM   6876 C  C   . GLU D 2 20  ? -42.888 -12.772 22.207  1    56.72  ? 190 GLU D C   1 
ATOM   6877 O  O   . GLU D 2 20  ? -42.138 -13.639 22.633  1    56.34  ? 190 GLU D O   1 
ATOM   6878 C  CB  . GLU D 2 20  ? -45.087 -12.716 23.45   1    58.43  ? 190 GLU D CB  1 
ATOM   6879 C  CG  . GLU D 2 20  ? -45.885 -13.11  22.214  1    56.79  ? 190 GLU D CG  1 
ATOM   6880 C  CD  . GLU D 2 20  ? -47.152 -13.919 22.49   1    60.32  ? 190 GLU D CD  1 
ATOM   6881 O  OE1 . GLU D 2 20  ? -47.306 -14.419 23.639  1    54.72  ? 190 GLU D OE1 1 
ATOM   6882 O  OE2 . GLU D 2 20  ? -47.999 -14.046 21.54   1    60.69  ? 190 GLU D OE2 1 
ATOM   6883 N  N   . VAL D 2 21  ? -42.958 -12.449 20.911  1    56.44  ? 191 VAL D N   1 
ATOM   6884 C  CA  . VAL D 2 21  ? -42.102 -13.109 19.944  1    56.78  ? 191 VAL D CA  1 
ATOM   6885 C  C   . VAL D 2 21  ? -40.662 -12.697 20.214  1    58.06  ? 191 VAL D C   1 
ATOM   6886 O  O   . VAL D 2 21  ? -39.776 -13.534 20.213  1    61.2   ? 191 VAL D O   1 
ATOM   6887 C  CB  . VAL D 2 21  ? -42.519 -12.856 18.477  1    57.78  ? 191 VAL D CB  1 
ATOM   6888 C  CG1 . VAL D 2 21  ? -41.416 -13.175 17.472  1    52.88  ? 191 VAL D CG1 1 
ATOM   6889 C  CG2 . VAL D 2 21  ? -43.791 -13.627 18.119  1    54.81  ? 191 VAL D CG2 1 
ATOM   6890 N  N   . LYS D 2 22  ? -40.429 -11.415 20.48   1    61.64  ? 192 LYS D N   1 
ATOM   6891 C  CA  . LYS D 2 22  ? -39.052 -10.906 20.706  1    60.32  ? 192 LYS D CA  1 
ATOM   6892 C  C   . LYS D 2 22  ? -38.46  -11.444 22.012  1    56     ? 192 LYS D C   1 
ATOM   6893 O  O   . LYS D 2 22  ? -37.266 -11.781 22.019  1    58.85  ? 192 LYS D O   1 
ATOM   6894 C  CB  . LYS D 2 22  ? -39.082 -9.379  20.776  1    66.57  ? 192 LYS D CB  1 
ATOM   6895 C  CG  . LYS D 2 22  ? -37.83  -8.71   21.32   1    75.29  ? 192 LYS D CG  1 
ATOM   6896 C  CD  . LYS D 2 22  ? -38.073 -7.886  22.578  1    77.77  ? 192 LYS D CD  1 
ATOM   6897 C  CE  . LYS D 2 22  ? -36.8   -7.41   23.201  1    90.15  ? 192 LYS D CE  1 
ATOM   6898 N  NZ  . LYS D 2 22  ? -36.131 -8.47   23.959  1    96.11  ? 192 LYS D NZ  1 
ATOM   6899 N  N   . CYS D 2 23  ? -39.265 -11.544 23.062  1    53.95  ? 193 CYS D N   1 
ATOM   6900 C  CA  . CYS D 2 23  ? -38.759 -11.95  24.371  1    54.76  ? 193 CYS D CA  1 
ATOM   6901 C  C   . CYS D 2 23  ? -38.807 -13.471 24.568  1    56.23  ? 193 CYS D C   1 
ATOM   6902 O  O   . CYS D 2 23  ? -38.692 -13.948 25.693  1    59.34  ? 193 CYS D O   1 
ATOM   6903 C  CB  . CYS D 2 23  ? -39.571 -11.355 25.524  1    54.2   ? 193 CYS D CB  1 
ATOM   6904 S  SG  . CYS D 2 23  ? -39.529 -9.54   25.658  1    61.64  ? 193 CYS D SG  1 
ATOM   6905 N  N   . LYS D 2 24  ? -38.965 -14.241 23.492  1    58.02  ? 194 LYS D N   1 
ATOM   6906 C  CA  . LYS D 2 24  ? -39.158 -15.679 23.614  1    59.05  ? 194 LYS D CA  1 
ATOM   6907 C  C   . LYS D 2 24  ? -37.805 -16.359 23.801  1    58.75  ? 194 LYS D C   1 
ATOM   6908 O  O   . LYS D 2 24  ? -36.904 -16.148 23.007  1    57.36  ? 194 LYS D O   1 
ATOM   6909 C  CB  . LYS D 2 24  ? -39.85  -16.273 22.375  1    56.55  ? 194 LYS D CB  1 
ATOM   6910 C  CG  . LYS D 2 24  ? -40.36  -17.696 22.552  1    57.64  ? 194 LYS D CG  1 
ATOM   6911 C  CD  . LYS D 2 24  ? -40.58  -18.411 21.226  1    67.49  ? 194 LYS D CD  1 
ATOM   6912 C  CE  . LYS D 2 24  ? -40.964 -19.879 21.38   1    71.01  ? 194 LYS D CE  1 
ATOM   6913 N  NZ  . LYS D 2 24  ? -41.838 -20.329 20.297  1    68.54  ? 194 LYS D NZ  1 
ATOM   6914 N  N   . PRO D 2 25  ? -37.641 -17.247 24.813  1    58.96  ? 195 PRO D N   1 
ATOM   6915 C  CA  . PRO D 2 25  ? -36.395 -18.001 24.986  1    55.03  ? 195 PRO D CA  1 
ATOM   6916 C  C   . PRO D 2 25  ? -36.125 -18.923 23.806  1    58.35  ? 195 PRO D C   1 
ATOM   6917 O  O   . PRO D 2 25  ? -37.038 -19.215 23.048  1    64.51  ? 195 PRO D O   1 
ATOM   6918 C  CB  . PRO D 2 25  ? -36.656 -18.823 26.244  1    54.78  ? 195 PRO D CB  1 
ATOM   6919 C  CG  . PRO D 2 25  ? -37.793 -18.106 26.949  1    56.39  ? 195 PRO D CG  1 
ATOM   6920 C  CD  . PRO D 2 25  ? -38.657 -17.57  25.834  1    58.05  ? 195 PRO D CD  1 
ATOM   6921 N  N   . LYS D 2 26  ? -34.917 -19.48  23.758  1    59.14  ? 196 LYS D N   1 
ATOM   6922 C  CA  . LYS D 2 26  ? -34.583 -20.5   22.739  1    60.97  ? 196 LYS D CA  1 
ATOM   6923 C  C   . LYS D 2 26  ? -35.254 -21.813 23.149  1    63.75  ? 196 LYS D C   1 
ATOM   6924 O  O   . LYS D 2 26  ? -35.001 -22.264 24.275  1    69.25  ? 196 LYS D O   1 
ATOM   6925 C  CB  . LYS D 2 26  ? -33.069 -20.687 22.693  1    64.98  ? 196 LYS D CB  1 
ATOM   6926 C  CG  . LYS D 2 26  ? -32.279 -19.496 22.182  1    76.36  ? 196 LYS D CG  1 
ATOM   6927 C  CD  . LYS D 2 26  ? -30.773 -19.717 22.176  1    86.46  ? 196 LYS D CD  1 
ATOM   6928 C  CE  . LYS D 2 26  ? -30.038 -18.531 21.644  1    93.66  ? 196 LYS D CE  1 
ATOM   6929 N  NZ  . LYS D 2 26  ? -28.588 -18.741 21.662  1    89.56  ? 196 LYS D NZ  1 
ATOM   6930 N  N   . VAL D 2 27  ? -36.047 -22.418 22.263  1    68.44  ? 197 VAL D N   1 
ATOM   6931 C  CA  . VAL D 2 27  ? -36.827 -23.644 22.613  1    73.35  ? 197 VAL D CA  1 
ATOM   6932 C  C   . VAL D 2 27  ? -35.896 -24.781 23.058  1    70.59  ? 197 VAL D C   1 
ATOM   6933 O  O   . VAL D 2 27  ? -36.287 -25.544 23.961  1    68.51  ? 197 VAL D O   1 
ATOM   6934 C  CB  . VAL D 2 27  ? -37.697 -24.056 21.413  1    76.53  ? 197 VAL D CB  1 
ATOM   6935 C  CG1 . VAL D 2 27  ? -38.342 -25.421 21.605  1    80.57  ? 197 VAL D CG1 1 
ATOM   6936 C  CG2 . VAL D 2 27  ? -38.748 -23.002 21.097  1    75.22  ? 197 VAL D CG2 1 
ATOM   6937 N  N   . GLY D 2 28  ? -34.709 -24.881 22.471  1    63.71  ? 198 GLY D N   1 
ATOM   6938 C  CA  . GLY D 2 28  ? -33.841 -26.014 22.823  1    72.18  ? 198 GLY D CA  1 
ATOM   6939 C  C   . GLY D 2 28  ? -32.598 -25.567 23.547  1    75.96  ? 198 GLY D C   1 
ATOM   6940 O  O   . GLY D 2 28  ? -31.504 -25.962 23.112  1    88.3   ? 198 GLY D O   1 
ATOM   6941 N  N   . TYR D 2 29  ? -32.747 -24.805 24.629  1    67.76  ? 199 TYR D N   1 
ATOM   6942 C  CA  . TYR D 2 29  ? -31.547 -24.247 25.306  1    60.18  ? 199 TYR D CA  1 
ATOM   6943 C  C   . TYR D 2 29  ? -30.993 -25.272 26.278  1    61.25  ? 199 TYR D C   1 
ATOM   6944 O  O   . TYR D 2 29  ? -29.776 -25.289 26.493  1    58.42  ? 199 TYR D O   1 
ATOM   6945 C  CB  . TYR D 2 29  ? -31.891 -22.879 25.911  1    55.45  ? 199 TYR D CB  1 
ATOM   6946 C  CG  . TYR D 2 29  ? -32.57  -22.795 27.271  1    49.71  ? 199 TYR D CG  1 
ATOM   6947 C  CD1 . TYR D 2 29  ? -31.934 -23.223 28.428  1    50.3   ? 199 TYR D CD1 1 
ATOM   6948 C  CD2 . TYR D 2 29  ? -33.829 -22.226 27.4    1    46.24  ? 199 TYR D CD2 1 
ATOM   6949 C  CE1 . TYR D 2 29  ? -32.55  -23.143 29.662  1    48.4   ? 199 TYR D CE1 1 
ATOM   6950 C  CE2 . TYR D 2 29  ? -34.451 -22.126 28.631  1    46.65  ? 199 TYR D CE2 1 
ATOM   6951 C  CZ  . TYR D 2 29  ? -33.809 -22.585 29.764  1    49.07  ? 199 TYR D CZ  1 
ATOM   6952 O  OH  . TYR D 2 29  ? -34.405 -22.493 30.983  1    51     ? 199 TYR D OH  1 
ATOM   6953 N  N   . MET D 2 30  ? -31.857 -26.1   26.858  1    60.56  ? 200 MET D N   1 
ATOM   6954 C  CA  . MET D 2 30  ? -31.366 -27.035 27.897  1    60.54  ? 200 MET D CA  1 
ATOM   6955 C  C   . MET D 2 30  ? -30.466 -28.093 27.253  1    64.51  ? 200 MET D C   1 
ATOM   6956 O  O   . MET D 2 30  ? -29.531 -28.55  27.928  1    61.25  ? 200 MET D O   1 
ATOM   6957 C  CB  . MET D 2 30  ? -32.522 -27.684 28.656  1    66.75  ? 200 MET D CB  1 
ATOM   6958 C  CG  . MET D 2 30  ? -32.159 -28.116 30.053  1    61.56  ? 200 MET D CG  1 
ATOM   6959 S  SD  . MET D 2 30  ? -31.69  -26.702 31.064  1    64.29  ? 200 MET D SD  1 
ATOM   6960 C  CE  . MET D 2 30  ? -33.33  -26.115 31.501  1    59.92  ? 200 MET D CE  1 
ATOM   6961 N  N   . LYS D 2 31  ? -30.732 -28.469 25.999  1    66.06  ? 201 LYS D N   1 
ATOM   6962 C  CA  . LYS D 2 31  ? -29.788 -29.395 25.395  1    69.18  ? 201 LYS D CA  1 
ATOM   6963 C  C   . LYS D 2 31  ? -28.395 -28.773 25.374  1    69.41  ? 201 LYS D C   1 
ATOM   6964 O  O   . LYS D 2 31  ? -27.424 -29.471 25.642  1    69.8   ? 201 LYS D O   1 
ATOM   6965 C  CB  . LYS D 2 31  ? -30.209 -29.862 24      1    73.71  ? 201 LYS D CB  1 
ATOM   6966 C  CG  . LYS D 2 31  ? -31.297 -30.931 23.972  1    79.65  ? 201 LYS D CG  1 
ATOM   6967 C  CD  . LYS D 2 31  ? -31.947 -31.197 22.611  1    89.59  ? 201 LYS D CD  1 
ATOM   6968 C  CE  . LYS D 2 31  ? -32.666 -29.992 22.025  1    91.26  ? 201 LYS D CE  1 
ATOM   6969 N  NZ  . LYS D 2 31  ? -31.911 -29.2   21.044  1    92.52  ? 201 LYS D NZ  1 
ATOM   6970 N  N   . LYS D 2 32  ? -28.314 -27.463 25.084  1    66.46  ? 202 LYS D N   1 
ATOM   6971 C  CA  . LYS D 2 32  ? -27.053 -26.743 24.999  1    65.66  ? 202 LYS D CA  1 
ATOM   6972 C  C   . LYS D 2 32  ? -26.415 -26.442 26.363  1    63.2   ? 202 LYS D C   1 
ATOM   6973 O  O   . LYS D 2 32  ? -25.256 -26.025 26.384  1    63.29  ? 202 LYS D O   1 
ATOM   6974 C  CB  . LYS D 2 32  ? -27.214 -25.429 24.229  1    69.44  ? 202 LYS D CB  1 
ATOM   6975 C  CG  . LYS D 2 32  ? -27.05  -25.533 22.713  1    77.54  ? 202 LYS D CG  1 
ATOM   6976 C  CD  . LYS D 2 32  ? -28.327 -25.643 21.887  1    78     ? 202 LYS D CD  1 
ATOM   6977 C  CE  . LYS D 2 32  ? -27.984 -25.345 20.445  1    82.15  ? 202 LYS D CE  1 
ATOM   6978 N  NZ  . LYS D 2 32  ? -29.084 -25.631 19.515  1    84.15  ? 202 LYS D NZ  1 
ATOM   6979 N  N   . GLN D 2 33  ? -27.143 -26.63  27.481  1    61.4   ? 203 GLN D N   1 
ATOM   6980 C  CA  . GLN D 2 33  ? -26.612 -26.456 28.836  1    56.49  ? 203 GLN D CA  1 
ATOM   6981 C  C   . GLN D 2 33  ? -25.984 -27.768 29.307  1    60.63  ? 203 GLN D C   1 
ATOM   6982 O  O   . GLN D 2 33  ? -26.693 -28.737 29.636  1    63.49  ? 203 GLN D O   1 
ATOM   6983 C  CB  . GLN D 2 33  ? -27.654 -26.074 29.887  1    49.59  ? 203 GLN D CB  1 
ATOM   6984 C  CG  . GLN D 2 33  ? -28.257 -24.684 29.729  1    48.14  ? 203 GLN D CG  1 
ATOM   6985 C  CD  . GLN D 2 33  ? -27.321 -23.569 30.15   1    48.54  ? 203 GLN D CD  1 
ATOM   6986 O  OE1 . GLN D 2 33  ? -26.288 -23.783 30.804  1    49.52  ? 203 GLN D OE1 1 
ATOM   6987 N  NE2 . GLN D 2 33  ? -27.685 -22.351 29.769  1    46.39  ? 203 GLN D NE2 1 
ATOM   6988 N  N   . PRO D 2 34  ? -24.635 -27.83  29.386  1    61.24  ? 204 PRO D N   1 
ATOM   6989 C  CA  . PRO D 2 34  ? -23.952 -29.09  29.694  1    62.79  ? 204 PRO D CA  1 
ATOM   6990 C  C   . PRO D 2 34  ? -24.161 -29.569 31.136  1    63.72  ? 204 PRO D C   1 
ATOM   6991 O  O   . PRO D 2 34  ? -24.063 -30.766 31.419  1    69.26  ? 204 PRO D O   1 
ATOM   6992 C  CB  . PRO D 2 34  ? -22.475 -28.791 29.352  1    59.3   ? 204 PRO D CB  1 
ATOM   6993 C  CG  . PRO D 2 34  ? -22.354 -27.284 29.53   1    63.1   ? 204 PRO D CG  1 
ATOM   6994 C  CD  . PRO D 2 34  ? -23.714 -26.687 29.211  1    60.64  ? 204 PRO D CD  1 
ATOM   6995 N  N   . ASP D 2 35  ? -24.498 -28.634 32.031  1    59.63  ? 205 ASP D N   1 
ATOM   6996 C  CA  . ASP D 2 35  ? -24.496 -28.934 33.448  1    61.37  ? 205 ASP D CA  1 
ATOM   6997 C  C   . ASP D 2 35  ? -25.879 -28.876 34.098  1    61.74  ? 205 ASP D C   1 
ATOM   6998 O  O   . ASP D 2 35  ? -26.031 -29.328 35.226  1    67.1   ? 205 ASP D O   1 
ATOM   6999 C  CB  . ASP D 2 35  ? -23.523 -28.069 34.221  1    62.48  ? 205 ASP D CB  1 
ATOM   7000 C  CG  . ASP D 2 35  ? -23.136 -28.696 35.553  1    68.77  ? 205 ASP D CG  1 
ATOM   7001 O  OD1 . ASP D 2 35  ? -22.506 -29.778 35.51   1    81.05  ? 205 ASP D OD1 1 
ATOM   7002 O  OD2 . ASP D 2 35  ? -23.515 -28.143 36.61   1    65.62  ? 205 ASP D OD2 1 
ATOM   7003 N  N   . ILE D 2 36  ? -26.88  -28.313 33.425  1    58.8   ? 206 ILE D N   1 
ATOM   7004 C  CA  . ILE D 2 36  ? -28.195 -28.197 34.033  1    59.41  ? 206 ILE D CA  1 
ATOM   7005 C  C   . ILE D 2 36  ? -29.25  -28.834 33.127  1    60.82  ? 206 ILE D C   1 
ATOM   7006 O  O   . ILE D 2 36  ? -29.004 -29.053 31.941  1    67.38  ? 206 ILE D O   1 
ATOM   7007 C  CB  . ILE D 2 36  ? -28.507 -26.737 34.418  1    62.41  ? 206 ILE D CB  1 
ATOM   7008 C  CG1 . ILE D 2 36  ? -28.48  -25.821 33.247  1    58.66  ? 206 ILE D CG1 1 
ATOM   7009 C  CG2 . ILE D 2 36  ? -27.56  -26.231 35.518  1    63.64  ? 206 ILE D CG2 1 
ATOM   7010 C  CD1 . ILE D 2 36  ? -28.909 -24.421 33.602  1    59.09  ? 206 ILE D CD1 1 
ATOM   7011 N  N   . THR D 2 37  ? -30.407 -29.175 33.71   1    56.75  ? 207 THR D N   1 
ATOM   7012 C  CA  . THR D 2 37  ? -31.44  -29.959 33.045  1    57.76  ? 207 THR D CA  1 
ATOM   7013 C  C   . THR D 2 37  ? -32.815 -29.354 33.305  1    57.69  ? 207 THR D C   1 
ATOM   7014 O  O   . THR D 2 37  ? -32.956 -28.437 34.116  1    58.01  ? 207 THR D O   1 
ATOM   7015 C  CB  . THR D 2 37  ? -31.423 -31.417 33.51   1    58.84  ? 207 THR D CB  1 
ATOM   7016 O  OG1 . THR D 2 37  ? -31.891 -31.432 34.859  1    65.28  ? 207 THR D OG1 1 
ATOM   7017 C  CG2 . THR D 2 37  ? -30.044 -32.036 33.423  1    55.29  ? 207 THR D CG2 1 
ATOM   7018 N  N   . ASN D 2 38  ? -33.831 -29.906 32.627  1    59.58  ? 208 ASN D N   1 
ATOM   7019 C  CA  . ASN D 2 38  ? -35.205 -29.443 32.769  1    57.63  ? 208 ASN D CA  1 
ATOM   7020 C  C   . ASN D 2 38  ? -35.658 -29.648 34.213  1    56.91  ? 208 ASN D C   1 
ATOM   7021 O  O   . ASN D 2 38  ? -36.423 -28.866 34.753  1    54.83  ? 208 ASN D O   1 
ATOM   7022 C  CB  . ASN D 2 38  ? -36.119 -30.175 31.79   1    61.43  ? 208 ASN D CB  1 
ATOM   7023 C  CG  . ASN D 2 38  ? -36.021 -29.722 30.348  1    61.52  ? 208 ASN D CG  1 
ATOM   7024 O  OD1 . ASN D 2 38  ? -35.609 -28.602 30.037  1    59.6   ? 208 ASN D OD1 1 
ATOM   7025 N  ND2 . ASN D 2 38  ? -36.487 -30.564 29.443  1    65.56  ? 208 ASN D ND2 1 
ATOM   7026 N  N   . SER D 2 39  ? -35.184 -30.742 34.813  1    58.62  ? 209 SER D N   1 
ATOM   7027 C  CA  . SER D 2 39  ? -35.555 -31.153 36.151  1    58.93  ? 209 SER D CA  1 
ATOM   7028 C  C   . SER D 2 39  ? -35.052 -30.124 37.158  1    59.89  ? 209 SER D C   1 
ATOM   7029 O  O   . SER D 2 39  ? -35.774 -29.727 38.083  1    59.62  ? 209 SER D O   1 
ATOM   7030 C  CB  . SER D 2 39  ? -34.998 -32.523 36.427  1    57.12  ? 209 SER D CB  1 
ATOM   7031 O  OG  . SER D 2 39  ? -35.099 -32.831 37.801  1    56.29  ? 209 SER D OG  1 
ATOM   7032 N  N   . MET D 2 40  ? -33.791 -29.719 36.978  1    58.21  ? 210 MET D N   1 
ATOM   7033 C  CA  . MET D 2 40  ? -33.216 -28.693 37.835  1    56.25  ? 210 MET D CA  1 
ATOM   7034 C  C   . MET D 2 40  ? -33.997 -27.392 37.693  1    51.68  ? 210 MET D C   1 
ATOM   7035 O  O   . MET D 2 40  ? -34.288 -26.757 38.687  1    50.3   ? 210 MET D O   1 
ATOM   7036 C  CB  . MET D 2 40  ? -31.748 -28.466 37.488  1    54     ? 210 MET D CB  1 
ATOM   7037 C  CG  . MET D 2 40  ? -30.929 -29.668 37.8    1    58.7   ? 210 MET D CG  1 
ATOM   7038 S  SD  . MET D 2 40  ? -29.221 -29.269 37.419  1    61.08  ? 210 MET D SD  1 
ATOM   7039 C  CE  . MET D 2 40  ? -28.584 -30.93  37.16   1    56.44  ? 210 MET D CE  1 
ATOM   7040 N  N   . ARG D 2 41  ? -34.372 -27.039 36.463  1    50     ? 211 ARG D N   1 
ATOM   7041 C  CA  . ARG D 2 41  ? -35.141 -25.834 36.209  1    48.77  ? 211 ARG D CA  1 
ATOM   7042 C  C   . ARG D 2 41  ? -36.481 -25.894 36.942  1    51.53  ? 211 ARG D C   1 
ATOM   7043 O  O   . ARG D 2 41  ? -36.944 -24.862 37.444  1    51.81  ? 211 ARG D O   1 
ATOM   7044 C  CB  . ARG D 2 41  ? -35.321 -25.646 34.701  1    48.57  ? 211 ARG D CB  1 
ATOM   7045 C  CG  . ARG D 2 41  ? -35.996 -24.339 34.314  1    47.81  ? 211 ARG D CG  1 
ATOM   7046 C  CD  . ARG D 2 41  ? -36.352 -24.299 32.831  1    49.99  ? 211 ARG D CD  1 
ATOM   7047 N  NE  . ARG D 2 41  ? -37.381 -23.301 32.521  1    50.1   ? 211 ARG D NE  1 
ATOM   7048 C  CZ  . ARG D 2 41  ? -38.657 -23.333 32.908  1    47.38  ? 211 ARG D CZ  1 
ATOM   7049 N  NH1 . ARG D 2 41  ? -39.129 -24.369 33.576  1    47.71  ? 211 ARG D NH1 1 
ATOM   7050 N  NH2 . ARG D 2 41  ? -39.446 -22.317 32.632  1    45.15  ? 211 ARG D NH2 1 
ATOM   7051 N  N   . ALA D 2 42  ? -37.087 -27.095 36.994  1    49.91  ? 212 ALA D N   1 
ATOM   7052 C  CA  . ALA D 2 42  ? -38.373 -27.331 37.636  1    50.06  ? 212 ALA D CA  1 
ATOM   7053 C  C   . ALA D 2 42  ? -38.267 -27.107 39.149  1    51.06  ? 212 ALA D C   1 
ATOM   7054 O  O   . ALA D 2 42  ? -39.155 -26.507 39.775  1    50.29  ? 212 ALA D O   1 
ATOM   7055 C  CB  . ALA D 2 42  ? -38.885 -28.721 37.305  1    48.45  ? 212 ALA D CB  1 
ATOM   7056 N  N   . ILE D 2 43  ? -37.176 -27.595 39.741  1    50.14  ? 213 ILE D N   1 
ATOM   7057 C  CA  . ILE D 2 43  ? -36.946 -27.35  41.151  1    52.35  ? 213 ILE D CA  1 
ATOM   7058 C  C   . ILE D 2 43  ? -36.883 -25.841 41.414  1    56.36  ? 213 ILE D C   1 
ATOM   7059 O  O   . ILE D 2 43  ? -37.465 -25.342 42.38   1    58.67  ? 213 ILE D O   1 
ATOM   7060 C  CB  . ILE D 2 43  ? -35.677 -28.078 41.606  1    50.54  ? 213 ILE D CB  1 
ATOM   7061 C  CG1 . ILE D 2 43  ? -35.908 -29.569 41.623  1    48.62  ? 213 ILE D CG1 1 
ATOM   7062 C  CG2 . ILE D 2 43  ? -35.213 -27.546 42.966  1    49.59  ? 213 ILE D CG2 1 
ATOM   7063 C  CD1 . ILE D 2 43  ? -34.621 -30.36  41.547  1    50.73  ? 213 ILE D CD1 1 
ATOM   7064 N  N   . LEU D 2 44  ? -36.186 -25.124 40.534  1    54.64  ? 214 LEU D N   1 
ATOM   7065 C  CA  . LEU D 2 44  ? -35.973 -23.7   40.698  1    56.12  ? 214 LEU D CA  1 
ATOM   7066 C  C   . LEU D 2 44  ? -37.301 -22.956 40.612  1    55.83  ? 214 LEU D C   1 
ATOM   7067 O  O   . LEU D 2 44  ? -37.612 -22.138 41.474  1    53.7   ? 214 LEU D O   1 
ATOM   7068 C  CB  . LEU D 2 44  ? -34.976 -23.206 39.65   1    54.65  ? 214 LEU D CB  1 
ATOM   7069 C  CG  . LEU D 2 44  ? -34.797 -21.688 39.584  1    52.4   ? 214 LEU D CG  1 
ATOM   7070 C  CD1 . LEU D 2 44  ? -34.11  -21.244 40.852  1    56.13  ? 214 LEU D CD1 1 
ATOM   7071 C  CD2 . LEU D 2 44  ? -33.987 -21.299 38.375  1    50.75  ? 214 LEU D CD2 1 
ATOM   7072 N  N   . VAL D 2 45  ? -38.072 -23.233 39.556  1    54.52  ? 215 VAL D N   1 
ATOM   7073 C  CA  . VAL D 2 45  ? -39.324 -22.517 39.362  1    54.54  ? 215 VAL D CA  1 
ATOM   7074 C  C   . VAL D 2 45  ? -40.265 -22.809 40.533  1    53.72  ? 215 VAL D C   1 
ATOM   7075 O  O   . VAL D 2 45  ? -40.951 -21.915 41.021  1    49.69  ? 215 VAL D O   1 
ATOM   7076 C  CB  . VAL D 2 45  ? -39.961 -22.831 37.995  1    52.73  ? 215 VAL D CB  1 
ATOM   7077 C  CG1 . VAL D 2 45  ? -41.263 -22.055 37.796  1    50.32  ? 215 VAL D CG1 1 
ATOM   7078 C  CG2 . VAL D 2 45  ? -38.974 -22.528 36.86   1    48.88  ? 215 VAL D CG2 1 
ATOM   7079 N  N   . ASP D 2 46  ? -40.279 -24.067 40.997  1    54.85  ? 216 ASP D N   1 
ATOM   7080 C  CA  . ASP D 2 46  ? -41.151 -24.434 42.1    1    53.35  ? 216 ASP D CA  1 
ATOM   7081 C  C   . ASP D 2 46  ? -40.728 -23.704 43.365  1    52.98  ? 216 ASP D C   1 
ATOM   7082 O  O   . ASP D 2 46  ? -41.569 -23.389 44.201  1    55.95  ? 216 ASP D O   1 
ATOM   7083 C  CB  . ASP D 2 46  ? -41.087 -25.913 42.396  1    55.83  ? 216 ASP D CB  1 
ATOM   7084 C  CG  . ASP D 2 46  ? -42.145 -26.383 43.38   1    59.3   ? 216 ASP D CG  1 
ATOM   7085 O  OD1 . ASP D 2 46  ? -43.313 -26.573 42.935  1    59.64  ? 216 ASP D OD1 1 
ATOM   7086 O  OD2 . ASP D 2 46  ? -41.804 -26.5   44.587  1    57.2   ? 216 ASP D OD2 1 
ATOM   7087 N  N   . TRP D 2 47  ? -39.413 -23.495 43.523  1    51.99  ? 217 TRP D N   1 
ATOM   7088 C  CA  . TRP D 2 47  ? -38.902 -22.712 44.633  1    51.96  ? 217 TRP D CA  1 
ATOM   7089 C  C   . TRP D 2 47  ? -39.306 -21.243 44.503  1    50.01  ? 217 TRP D C   1 
ATOM   7090 O  O   . TRP D 2 47  ? -39.686 -20.622 45.482  1    49.64  ? 217 TRP D O   1 
ATOM   7091 C  CB  . TRP D 2 47  ? -37.39  -22.863 44.79   1    50.83  ? 217 TRP D CB  1 
ATOM   7092 C  CG  . TRP D 2 47  ? -36.798 -21.937 45.829  1    53.13  ? 217 TRP D CG  1 
ATOM   7093 C  CD1 . TRP D 2 47  ? -36.943 -22.036 47.186  1    51.03  ? 217 TRP D CD1 1 
ATOM   7094 C  CD2 . TRP D 2 47  ? -35.911 -20.816 45.59   1    48.24  ? 217 TRP D CD2 1 
ATOM   7095 N  NE1 . TRP D 2 47  ? -36.221 -21.049 47.801  1    52.1   ? 217 TRP D NE1 1 
ATOM   7096 C  CE2 . TRP D 2 47  ? -35.57  -20.293 46.854  1    49.3   ? 217 TRP D CE2 1 
ATOM   7097 C  CE3 . TRP D 2 47  ? -35.361 -20.235 44.446  1    47.33  ? 217 TRP D CE3 1 
ATOM   7098 C  CZ2 . TRP D 2 47  ? -34.722 -19.195 47.006  1    47.99  ? 217 TRP D CZ2 1 
ATOM   7099 C  CZ3 . TRP D 2 47  ? -34.507 -19.157 44.596  1    50.69  ? 217 TRP D CZ3 1 
ATOM   7100 C  CH2 . TRP D 2 47  ? -34.197 -18.645 45.861  1    48.86  ? 217 TRP D CH2 1 
ATOM   7101 N  N   . LEU D 2 48  ? -39.271 -20.706 43.281  1    49.27  ? 218 LEU D N   1 
ATOM   7102 C  CA  . LEU D 2 48  ? -39.705 -19.335 43.072  1    46.14  ? 218 LEU D CA  1 
ATOM   7103 C  C   . LEU D 2 48  ? -41.191 -19.141 43.401  1    50.68  ? 218 LEU D C   1 
ATOM   7104 O  O   . LEU D 2 48  ? -41.579 -18.072 43.867  1    56.77  ? 218 LEU D O   1 
ATOM   7105 C  CB  . LEU D 2 48  ? -39.338 -18.936 41.654  1    42.8   ? 218 LEU D CB  1 
ATOM   7106 C  CG  . LEU D 2 48  ? -37.848 -18.661 41.436  1    44.23  ? 218 LEU D CG  1 
ATOM   7107 C  CD1 . LEU D 2 48  ? -37.587 -18.248 39.997  1    42.45  ? 218 LEU D CD1 1 
ATOM   7108 C  CD2 . LEU D 2 48  ? -37.336 -17.583 42.384  1    42.66  ? 218 LEU D CD2 1 
ATOM   7109 N  N   . VAL D 2 49  ? -42.027 -20.17  43.197  1    50.68  ? 219 VAL D N   1 
ATOM   7110 C  CA  . VAL D 2 49  ? -43.432 -20.099 43.578  1    52.14  ? 219 VAL D CA  1 
ATOM   7111 C  C   . VAL D 2 49  ? -43.548 -19.936 45.097  1    54.82  ? 219 VAL D C   1 
ATOM   7112 O  O   . VAL D 2 49  ? -44.285 -19.074 45.588  1    56.65  ? 219 VAL D O   1 
ATOM   7113 C  CB  . VAL D 2 49  ? -44.204 -21.343 43.091  1    51.5   ? 219 VAL D CB  1 
ATOM   7114 C  CG1 . VAL D 2 49  ? -45.575 -21.437 43.757  1    50.13  ? 219 VAL D CG1 1 
ATOM   7115 C  CG2 . VAL D 2 49  ? -44.311 -21.379 41.571  1    47.06  ? 219 VAL D CG2 1 
ATOM   7116 N  N   . GLU D 2 50  ? -42.825 -20.789 45.839  1    55.62  ? 220 GLU D N   1 
ATOM   7117 C  CA  . GLU D 2 50  ? -42.781 -20.682 47.29   1    58.16  ? 220 GLU D CA  1 
ATOM   7118 C  C   . GLU D 2 50  ? -42.368 -19.273 47.698  1    55.6   ? 220 GLU D C   1 
ATOM   7119 O  O   . GLU D 2 50  ? -43.069 -18.634 48.478  1    55.65  ? 220 GLU D O   1 
ATOM   7120 C  CB  . GLU D 2 50  ? -41.81  -21.687 47.898  1    62.61  ? 220 GLU D CB  1 
ATOM   7121 C  CG  . GLU D 2 50  ? -42.388 -23.094 47.914  1    73.89  ? 220 GLU D CG  1 
ATOM   7122 C  CD  . GLU D 2 50  ? -41.619 -24.049 48.809  1    83.21  ? 220 GLU D CD  1 
ATOM   7123 O  OE1 . GLU D 2 50  ? -42.254 -25.018 49.33   1    91.39  ? 220 GLU D OE1 1 
ATOM   7124 O  OE2 . GLU D 2 50  ? -40.389 -23.831 48.945  1    80.57  ? 220 GLU D OE2 1 
ATOM   7125 N  N   . VAL D 2 51  ? -41.265 -18.784 47.12   1    51     ? 221 VAL D N   1 
ATOM   7126 C  CA  . VAL D 2 51  ? -40.771 -17.442 47.394  1    49.49  ? 221 VAL D CA  1 
ATOM   7127 C  C   . VAL D 2 51  ? -41.853 -16.381 47.164  1    51.39  ? 221 VAL D C   1 
ATOM   7128 O  O   . VAL D 2 51  ? -42.035 -15.508 48.006  1    51.3   ? 221 VAL D O   1 
ATOM   7129 C  CB  . VAL D 2 51  ? -39.487 -17.125 46.618  1    42.36  ? 221 VAL D CB  1 
ATOM   7130 C  CG1 . VAL D 2 51  ? -39.145 -15.664 46.789  1    39.16  ? 221 VAL D CG1 1 
ATOM   7131 C  CG2 . VAL D 2 51  ? -38.348 -18.004 47.105  1    39.68  ? 221 VAL D CG2 1 
ATOM   7132 N  N   . GLY D 2 52  ? -42.585 -16.491 46.048  1    51.1   ? 222 GLY D N   1 
ATOM   7133 C  CA  . GLY D 2 52  ? -43.7   -15.6   45.757  1    53.52  ? 222 GLY D CA  1 
ATOM   7134 C  C   . GLY D 2 52  ? -44.789 -15.605 46.833  1    58.65  ? 222 GLY D C   1 
ATOM   7135 O  O   . GLY D 2 52  ? -45.389 -14.556 47.078  1    62.36  ? 222 GLY D O   1 
ATOM   7136 N  N   . GLU D 2 53  ? -45.06  -16.769 47.446  1    60.31  ? 223 GLU D N   1 
ATOM   7137 C  CA  . GLU D 2 53  ? -46.108 -16.916 48.465  1    63.27  ? 223 GLU D CA  1 
ATOM   7138 C  C   . GLU D 2 53  ? -45.621 -16.413 49.82   1    62.1   ? 223 GLU D C   1 
ATOM   7139 O  O   . GLU D 2 53  ? -46.361 -15.73  50.518  1    72.5   ? 223 GLU D O   1 
ATOM   7140 C  CB  . GLU D 2 53  ? -46.653 -18.343 48.629  1    67.3   ? 223 GLU D CB  1 
ATOM   7141 C  CG  . GLU D 2 53  ? -47.548 -18.78  47.473  1    81.37  ? 223 GLU D CG  1 
ATOM   7142 C  CD  . GLU D 2 53  ? -48.583 -17.707 47.115  1    98.09  ? 223 GLU D CD  1 
ATOM   7143 O  OE1 . GLU D 2 53  ? -49.618 -17.626 47.838  1    95.96  ? 223 GLU D OE1 1 
ATOM   7144 O  OE2 . GLU D 2 53  ? -48.335 -16.923 46.145  1    93.94  ? 223 GLU D OE2 1 
ATOM   7145 N  N   . GLU D 2 54  ? -44.376 -16.745 50.182  1    59.25  ? 224 GLU D N   1 
ATOM   7146 C  CA  . GLU D 2 54  ? -43.752 -16.26  51.401  1    59.88  ? 224 GLU D CA  1 
ATOM   7147 C  C   . GLU D 2 54  ? -43.746 -14.731 51.45   1    58.94  ? 224 GLU D C   1 
ATOM   7148 O  O   . GLU D 2 54  ? -43.809 -14.163 52.533  1    60.47  ? 224 GLU D O   1 
ATOM   7149 C  CB  . GLU D 2 54  ? -42.344 -16.853 51.489  1    64.12  ? 224 GLU D CB  1 
ATOM   7150 C  CG  . GLU D 2 54  ? -41.496 -16.328 52.643  1    71.14  ? 224 GLU D CG  1 
ATOM   7151 C  CD  . GLU D 2 54  ? -42.062 -16.663 54.018  1    83.45  ? 224 GLU D CD  1 
ATOM   7152 O  OE1 . GLU D 2 54  ? -42.97  -17.524 54.061  1    89.84  ? 224 GLU D OE1 1 
ATOM   7153 O  OE2 . GLU D 2 54  ? -41.639 -16.071 55.043  1    88.24  ? 224 GLU D OE2 1 
ATOM   7154 N  N   . TYR D 2 55  ? -43.634 -14.058 50.301  1    57.51  ? 225 TYR D N   1 
ATOM   7155 C  CA  . TYR D 2 55  ? -43.444 -12.611 50.302  1    61.02  ? 225 TYR D CA  1 
ATOM   7156 C  C   . TYR D 2 55  ? -44.65  -11.897 49.691  1    62.83  ? 225 TYR D C   1 
ATOM   7157 O  O   . TYR D 2 55  ? -44.609 -10.683 49.486  1    60.77  ? 225 TYR D O   1 
ATOM   7158 C  CB  . TYR D 2 55  ? -42.118 -12.225 49.63   1    58.85  ? 225 TYR D CB  1 
ATOM   7159 C  CG  . TYR D 2 55  ? -40.883 -12.478 50.476  1    58.4   ? 225 TYR D CG  1 
ATOM   7160 C  CD1 . TYR D 2 55  ? -40.277 -13.726 50.493  1    61.81  ? 225 TYR D CD1 1 
ATOM   7161 C  CD2 . TYR D 2 55  ? -40.34  -11.482 51.283  1    57.38  ? 225 TYR D CD2 1 
ATOM   7162 C  CE1 . TYR D 2 55  ? -39.149 -13.959 51.271  1    61.65  ? 225 TYR D CE1 1 
ATOM   7163 C  CE2 . TYR D 2 55  ? -39.243 -11.717 52.096  1    56.31  ? 225 TYR D CE2 1 
ATOM   7164 C  CZ  . TYR D 2 55  ? -38.63  -12.958 52.068  1    58.59  ? 225 TYR D CZ  1 
ATOM   7165 O  OH  . TYR D 2 55  ? -37.523 -13.203 52.829  1    65.16  ? 225 TYR D OH  1 
ATOM   7166 N  N   . LYS D 2 56  ? -45.71  -12.674 49.413  1    64.49  ? 226 LYS D N   1 
ATOM   7167 C  CA  . LYS D 2 56  ? -46.965 -12.168 48.876  1    61.1   ? 226 LYS D CA  1 
ATOM   7168 C  C   . LYS D 2 56  ? -46.703 -11.273 47.669  1    55.56  ? 226 LYS D C   1 
ATOM   7169 O  O   . LYS D 2 56  ? -47.217 -10.164 47.617  1    52.84  ? 226 LYS D O   1 
ATOM   7170 C  CB  . LYS D 2 56  ? -47.792 -11.522 49.992  1    63.45  ? 226 LYS D CB  1 
ATOM   7171 C  CG  . LYS D 2 56  ? -48.068 -12.563 51.064  1    71.5   ? 226 LYS D CG  1 
ATOM   7172 C  CD  . LYS D 2 56  ? -48.317 -12.039 52.467  1    76.81  ? 226 LYS D CD  1 
ATOM   7173 C  CE  . LYS D 2 56  ? -49.77  -12.185 52.754  1    90.5   ? 226 LYS D CE  1 
ATOM   7174 N  NZ  . LYS D 2 56  ? -50.089 -11.698 54.106  1    98.36  ? 226 LYS D NZ  1 
ATOM   7175 N  N   . LEU D 2 57  ? -45.905 -11.789 46.722  1    52.49  ? 227 LEU D N   1 
ATOM   7176 C  CA  . LEU D 2 57  ? -45.598 -11.111 45.478  1    50.44  ? 227 LEU D CA  1 
ATOM   7177 C  C   . LEU D 2 57  ? -46.708 -11.379 44.481  1    52.14  ? 227 LEU D C   1 
ATOM   7178 O  O   . LEU D 2 57  ? -47.3   -12.45  44.513  1    56.69  ? 227 LEU D O   1 
ATOM   7179 C  CB  . LEU D 2 57  ? -44.282 -11.636 44.913  1    45.83  ? 227 LEU D CB  1 
ATOM   7180 C  CG  . LEU D 2 57  ? -43.069 -11.52  45.838  1    45.84  ? 227 LEU D CG  1 
ATOM   7181 C  CD1 . LEU D 2 57  ? -41.855 -11.984 45.065  1    40.34  ? 227 LEU D CD1 1 
ATOM   7182 C  CD2 . LEU D 2 57  ? -42.896 -10.098 46.409  1    44.23  ? 227 LEU D CD2 1 
ATOM   7183 N  N   . GLN D 2 58  ? -46.924 -10.419 43.575  1    54.29  ? 228 GLN D N   1 
ATOM   7184 C  CA  . GLN D 2 58  ? -47.819 -10.579 42.438  1    57.46  ? 228 GLN D CA  1 
ATOM   7185 C  C   . GLN D 2 58  ? -47.439 -11.843 41.674  1    55.33  ? 228 GLN D C   1 
ATOM   7186 O  O   . GLN D 2 58  ? -46.275 -12.216 41.608  1    51.03  ? 228 GLN D O   1 
ATOM   7187 C  CB  . GLN D 2 58  ? -47.722 -9.39   41.481  1    53.87  ? 228 GLN D CB  1 
ATOM   7188 C  CG  . GLN D 2 58  ? -48.198 -8.083  42.09   1    57.13  ? 228 GLN D CG  1 
ATOM   7189 C  CD  . GLN D 2 58  ? -49.66  -8.139  42.467  1    61.07  ? 228 GLN D CD  1 
ATOM   7190 O  OE1 . GLN D 2 58  ? -50.535 -8.088  41.607  1    72.46  ? 228 GLN D OE1 1 
ATOM   7191 N  NE2 . GLN D 2 58  ? -49.944 -8.246  43.748  1    60.17  ? 228 GLN D NE2 1 
ATOM   7192 N  N   . ASN D 2 59  ? -48.455 -12.491 41.106  1    58.2   ? 229 ASN D N   1 
ATOM   7193 C  CA  . ASN D 2 59  ? -48.247 -13.608 40.203  1    60.22  ? 229 ASN D CA  1 
ATOM   7194 C  C   . ASN D 2 59  ? -47.44  -13.174 38.971  1    54.08  ? 229 ASN D C   1 
ATOM   7195 O  O   . ASN D 2 59  ? -46.622 -13.942 38.46   1    52.85  ? 229 ASN D O   1 
ATOM   7196 C  CB  . ASN D 2 59  ? -49.584 -14.263 39.886  1    64.42  ? 229 ASN D CB  1 
ATOM   7197 C  CG  . ASN D 2 59  ? -50.086 -15.116 41.028  1    67.85  ? 229 ASN D CG  1 
ATOM   7198 O  OD1 . ASN D 2 59  ? -49.31  -15.596 41.859  1    64.37  ? 229 ASN D OD1 1 
ATOM   7199 N  ND2 . ASN D 2 59  ? -51.38  -15.384 41.04   1    70.51  ? 229 ASN D ND2 1 
ATOM   7200 N  N   . GLU D 2 60  ? -47.694 -11.943 38.505  1    50.9   ? 230 GLU D N   1 
ATOM   7201 C  CA  . GLU D 2 60  ? -47.008 -11.343 37.374  1    51.04  ? 230 GLU D CA  1 
ATOM   7202 C  C   . GLU D 2 60  ? -45.489 -11.377 37.595  1    50.84  ? 230 GLU D C   1 
ATOM   7203 O  O   . GLU D 2 60  ? -44.727 -11.707 36.691  1    52.83  ? 230 GLU D O   1 
ATOM   7204 C  CB  . GLU D 2 60  ? -47.544 -9.937  37.091  1    48.14  ? 230 GLU D CB  1 
ATOM   7205 C  CG  . GLU D 2 60  ? -46.773 -9.203  35.994  1    49.09  ? 230 GLU D CG  1 
ATOM   7206 C  CD  . GLU D 2 60  ? -46.921 -9.717  34.575  1    47.5   ? 230 GLU D CD  1 
ATOM   7207 O  OE1 . GLU D 2 60  ? -47.678 -10.679 34.407  1    50.53  ? 230 GLU D OE1 1 
ATOM   7208 O  OE2 . GLU D 2 60  ? -46.31  -9.163  33.647  1    46.36  ? 230 GLU D OE2 1 
ATOM   7209 N  N   . THR D 2 61  ? -45.071 -11.089 38.828  1    47.78  ? 231 THR D N   1 
ATOM   7210 C  CA  . THR D 2 61  ? -43.679 -11.069 39.224  1    46.06  ? 231 THR D CA  1 
ATOM   7211 C  C   . THR D 2 61  ? -43.069 -12.447 39.006  1    50.19  ? 231 THR D C   1 
ATOM   7212 O  O   . THR D 2 61  ? -41.95  -12.553 38.487  1    54.7   ? 231 THR D O   1 
ATOM   7213 C  CB  . THR D 2 61  ? -43.519 -10.617 40.677  1    44.78  ? 231 THR D CB  1 
ATOM   7214 O  OG1 . THR D 2 61  ? -44.227 -9.385  40.783  1    46.47  ? 231 THR D OG1 1 
ATOM   7215 C  CG2 . THR D 2 61  ? -42.06  -10.399 41.059  1    42.61  ? 231 THR D CG2 1 
ATOM   7216 N  N   . LEU D 2 62  ? -43.805 -13.493 39.403  1    51.5   ? 232 LEU D N   1 
ATOM   7217 C  CA  . LEU D 2 62  ? -43.35  -14.861 39.192  1    47.12  ? 232 LEU D CA  1 
ATOM   7218 C  C   . LEU D 2 62  ? -43.115 -15.105 37.705  1    47.22  ? 232 LEU D C   1 
ATOM   7219 O  O   . LEU D 2 62  ? -42.081 -15.634 37.302  1    47.4   ? 232 LEU D O   1 
ATOM   7220 C  CB  . LEU D 2 62  ? -44.373 -15.824 39.767  1    47.21  ? 232 LEU D CB  1 
ATOM   7221 C  CG  . LEU D 2 62  ? -44.174 -17.297 39.407  1    50.21  ? 232 LEU D CG  1 
ATOM   7222 C  CD1 . LEU D 2 62  ? -42.835 -17.822 39.913  1    48.29  ? 232 LEU D CD1 1 
ATOM   7223 C  CD2 . LEU D 2 62  ? -45.344 -18.136 39.91   1    49.32  ? 232 LEU D CD2 1 
ATOM   7224 N  N   . HIS D 2 63  ? -44.071 -14.699 36.876  1    48.29  ? 233 HIS D N   1 
ATOM   7225 C  CA  . HIS D 2 63  ? -43.983 -15.017 35.455  1    49.73  ? 233 HIS D CA  1 
ATOM   7226 C  C   . HIS D 2 63  ? -42.825 -14.274 34.803  1    50.15  ? 233 HIS D C   1 
ATOM   7227 O  O   . HIS D 2 63  ? -42.155 -14.821 33.938  1    50.99  ? 233 HIS D O   1 
ATOM   7228 C  CB  . HIS D 2 63  ? -45.271 -14.641 34.718  1    52.3   ? 233 HIS D CB  1 
ATOM   7229 C  CG  . HIS D 2 63  ? -46.365 -15.648 34.82   1    56.44  ? 233 HIS D CG  1 
ATOM   7230 N  ND1 . HIS D 2 63  ? -47.041 -15.894 35.999  1    58.44  ? 233 HIS D ND1 1 
ATOM   7231 C  CD2 . HIS D 2 63  ? -46.901 -16.447 33.889  1    53.58  ? 233 HIS D CD2 1 
ATOM   7232 C  CE1 . HIS D 2 63  ? -47.97  -16.809 35.778  1    60.95  ? 233 HIS D CE1 1 
ATOM   7233 N  NE2 . HIS D 2 63  ? -47.902 -17.15  34.508  1    62.13  ? 233 HIS D NE2 1 
ATOM   7234 N  N   . LEU D 2 64  ? -42.607 -13.014 35.217  1    49.26  ? 234 LEU D N   1 
ATOM   7235 C  CA  . LEU D 2 64  ? -41.538 -12.211 34.673  1    43.82  ? 234 LEU D CA  1 
ATOM   7236 C  C   . LEU D 2 64  ? -40.201 -12.885 34.993  1    49.45  ? 234 LEU D C   1 
ATOM   7237 O  O   . LEU D 2 64  ? -39.338 -13.02  34.094  1    49.48  ? 234 LEU D O   1 
ATOM   7238 C  CB  . LEU D 2 64  ? -41.623 -10.807 35.252  1    40.57  ? 234 LEU D CB  1 
ATOM   7239 C  CG  . LEU D 2 64  ? -42.686 -9.874  34.668  1    40.21  ? 234 LEU D CG  1 
ATOM   7240 C  CD1 . LEU D 2 64  ? -42.68  -8.581  35.479  1    40.08  ? 234 LEU D CD1 1 
ATOM   7241 C  CD2 . LEU D 2 64  ? -42.474 -9.576  33.187  1    38.42  ? 234 LEU D CD2 1 
ATOM   7242 N  N   . ALA D 2 65  ? -40.046 -13.309 36.262  1    44.29  ? 235 ALA D N   1 
ATOM   7243 C  CA  . ALA D 2 65  ? -38.804 -13.926 36.716  1    43.77  ? 235 ALA D CA  1 
ATOM   7244 C  C   . ALA D 2 65  ? -38.463 -15.154 35.871  1    44.99  ? 235 ALA D C   1 
ATOM   7245 O  O   . ALA D 2 65  ? -37.319 -15.323 35.464  1    48.43  ? 235 ALA D O   1 
ATOM   7246 C  CB  . ALA D 2 65  ? -38.891 -14.251 38.184  1    43.22  ? 235 ALA D CB  1 
ATOM   7247 N  N   . VAL D 2 66  ? -39.471 -15.98  35.563  1    43.61  ? 236 VAL D N   1 
ATOM   7248 C  CA  . VAL D 2 66  ? -39.266 -17.157 34.737  1    42.96  ? 236 VAL D CA  1 
ATOM   7249 C  C   . VAL D 2 66  ? -38.849 -16.747 33.318  1    49.54  ? 236 VAL D C   1 
ATOM   7250 O  O   . VAL D 2 66  ? -37.922 -17.34  32.753  1    53.2   ? 236 VAL D O   1 
ATOM   7251 C  CB  . VAL D 2 66  ? -40.509 -18.063 34.784  1    43.03  ? 236 VAL D CB  1 
ATOM   7252 C  CG1 . VAL D 2 66  ? -40.421 -19.213 33.803  1    40.28  ? 236 VAL D CG1 1 
ATOM   7253 C  CG2 . VAL D 2 66  ? -40.756 -18.585 36.212  1    43.64  ? 236 VAL D CG2 1 
ATOM   7254 N  N   . ASN D 2 67  ? -39.473 -15.696 32.75   1    50.38  ? 237 ASN D N   1 
ATOM   7255 C  CA  . ASN D 2 67  ? -39.089 -15.21  31.422  1    48.09  ? 237 ASN D CA  1 
ATOM   7256 C  C   . ASN D 2 67  ? -37.608 -14.805 31.435  1    48.02  ? 237 ASN D C   1 
ATOM   7257 O  O   . ASN D 2 67  ? -36.87  -15.087 30.472  1    43.47  ? 237 ASN D O   1 
ATOM   7258 C  CB  . ASN D 2 67  ? -39.973 -14.057 30.937  1    43.48  ? 237 ASN D CB  1 
ATOM   7259 C  CG  . ASN D 2 67  ? -39.46  -13.435 29.656  1    44.85  ? 237 ASN D CG  1 
ATOM   7260 O  OD1 . ASN D 2 67  ? -38.666 -12.483 29.676  1    44.75  ? 237 ASN D OD1 1 
ATOM   7261 N  ND2 . ASN D 2 67  ? -39.856 -13.98  28.517  1    44.21  ? 237 ASN D ND2 1 
ATOM   7262 N  N   . TYR D 2 68  ? -37.208 -14.107 32.516  1    44.17  ? 238 TYR D N   1 
ATOM   7263 C  CA  . TYR D 2 68  ? -35.837 -13.616 32.662  1    47     ? 238 TYR D CA  1 
ATOM   7264 C  C   . TYR D 2 68  ? -34.853 -14.793 32.748  1    48.77  ? 238 TYR D C   1 
ATOM   7265 O  O   . TYR D 2 68  ? -33.794 -14.741 32.129  1    47.3   ? 238 TYR D O   1 
ATOM   7266 C  CB  . TYR D 2 68  ? -35.66  -12.676 33.859  1    44.14  ? 238 TYR D CB  1 
ATOM   7267 C  CG  . TYR D 2 68  ? -36.546 -11.438 33.889  1    43.68  ? 238 TYR D CG  1 
ATOM   7268 C  CD1 . TYR D 2 68  ? -37.288 -11.045 32.774  1    43.98  ? 238 TYR D CD1 1 
ATOM   7269 C  CD2 . TYR D 2 68  ? -36.652 -10.673 35.044  1    39.47  ? 238 TYR D CD2 1 
ATOM   7270 C  CE1 . TYR D 2 68  ? -38.103 -9.919  32.795  1    42.11  ? 238 TYR D CE1 1 
ATOM   7271 C  CE2 . TYR D 2 68  ? -37.46  -9.549  35.085  1    41.74  ? 238 TYR D CE2 1 
ATOM   7272 C  CZ  . TYR D 2 68  ? -38.189 -9.174  33.959  1    45.03  ? 238 TYR D CZ  1 
ATOM   7273 O  OH  . TYR D 2 68  ? -39.011 -8.084  33.985  1    44.68  ? 238 TYR D OH  1 
ATOM   7274 N  N   . ILE D 2 69  ? -35.215 -15.86  33.49   1    48.7   ? 239 ILE D N   1 
ATOM   7275 C  CA  . ILE D 2 69  ? -34.376 -17.044 33.662  1    44.91  ? 239 ILE D CA  1 
ATOM   7276 C  C   . ILE D 2 69  ? -34.164 -17.755 32.322  1    46.47  ? 239 ILE D C   1 
ATOM   7277 O  O   . ILE D 2 69  ? -33.033 -17.992 31.885  1    47.01  ? 239 ILE D O   1 
ATOM   7278 C  CB  . ILE D 2 69  ? -34.962 -17.972 34.729  1    40.98  ? 239 ILE D CB  1 
ATOM   7279 C  CG1 . ILE D 2 69  ? -34.899 -17.301 36.116  1    40.63  ? 239 ILE D CG1 1 
ATOM   7280 C  CG2 . ILE D 2 69  ? -34.218 -19.294 34.731  1    40.16  ? 239 ILE D CG2 1 
ATOM   7281 C  CD1 . ILE D 2 69  ? -35.905 -17.811 37.127  1    36.26  ? 239 ILE D CD1 1 
ATOM   7282 N  N   . ASP D 2 70  ? -35.265 -18.02  31.626  1    47.36  ? 240 ASP D N   1 
ATOM   7283 C  CA  . ASP D 2 70  ? -35.192 -18.749 30.37   1    48.99  ? 240 ASP D CA  1 
ATOM   7284 C  C   . ASP D 2 70  ? -34.368 -17.985 29.336  1    45.98  ? 240 ASP D C   1 
ATOM   7285 O  O   . ASP D 2 70  ? -33.545 -18.584 28.668  1    49.15  ? 240 ASP D O   1 
ATOM   7286 C  CB  . ASP D 2 70  ? -36.57  -19.201 29.943  1    50.37  ? 240 ASP D CB  1 
ATOM   7287 C  CG  . ASP D 2 70  ? -37.147 -20.283 30.843  1    52.1   ? 240 ASP D CG  1 
ATOM   7288 O  OD1 . ASP D 2 70  ? -36.325 -21.013 31.439  1    51.04  ? 240 ASP D OD1 1 
ATOM   7289 O  OD2 . ASP D 2 70  ? -38.405 -20.382 30.954  1    50.65  ? 240 ASP D OD2 1 
ATOM   7290 N  N   . ARG D 2 71  ? -34.556 -16.671 29.234  1    43.94  ? 241 ARG D N   1 
ATOM   7291 C  CA  . ARG D 2 71  ? -33.783 -15.875 28.292  1    44.8   ? 241 ARG D CA  1 
ATOM   7292 C  C   . ARG D 2 71  ? -32.293 -15.861 28.66   1    44.74  ? 241 ARG D C   1 
ATOM   7293 O  O   . ARG D 2 71  ? -31.421 -15.93  27.789  1    48.93  ? 241 ARG D O   1 
ATOM   7294 C  CB  . ARG D 2 71  ? -34.32  -14.442 28.234  1    42.91  ? 241 ARG D CB  1 
ATOM   7295 C  CG  . ARG D 2 71  ? -35.511 -14.314 27.297  1    47.98  ? 241 ARG D CG  1 
ATOM   7296 C  CD  . ARG D 2 71  ? -36.396 -13.127 27.655  1    49.99  ? 241 ARG D CD  1 
ATOM   7297 N  NE  . ARG D 2 71  ? -35.756 -11.9   27.184  1    50.36  ? 241 ARG D NE  1 
ATOM   7298 C  CZ  . ARG D 2 71  ? -36.024 -10.7   27.692  1    48.79  ? 241 ARG D CZ  1 
ATOM   7299 N  NH1 . ARG D 2 71  ? -36.896 -10.597 28.681  1    46.37  ? 241 ARG D NH1 1 
ATOM   7300 N  NH2 . ARG D 2 71  ? -35.407 -9.629  27.209  1    46     ? 241 ARG D NH2 1 
ATOM   7301 N  N   . PHE D 2 72  ? -32.007 -15.783 29.956  1    43.78  ? 242 PHE D N   1 
ATOM   7302 C  CA  . PHE D 2 72  ? -30.636 -15.748 30.432  1    45.22  ? 242 PHE D CA  1 
ATOM   7303 C  C   . PHE D 2 72  ? -29.926 -17.063 30.094  1    48.85  ? 242 PHE D C   1 
ATOM   7304 O  O   . PHE D 2 72  ? -28.808 -17.057 29.577  1    49.87  ? 242 PHE D O   1 
ATOM   7305 C  CB  . PHE D 2 72  ? -30.634 -15.476 31.94   1    41.75  ? 242 PHE D CB  1 
ATOM   7306 C  CG  . PHE D 2 72  ? -29.241 -15.297 32.51   1    41.86  ? 242 PHE D CG  1 
ATOM   7307 C  CD1 . PHE D 2 72  ? -28.612 -14.065 32.421  1    40.91  ? 242 PHE D CD1 1 
ATOM   7308 C  CD2 . PHE D 2 72  ? -28.547 -16.373 33.065  1    43.91  ? 242 PHE D CD2 1 
ATOM   7309 C  CE1 . PHE D 2 72  ? -27.332 -13.919 32.919  1    45.47  ? 242 PHE D CE1 1 
ATOM   7310 C  CE2 . PHE D 2 72  ? -27.269 -16.213 33.547  1    41.03  ? 242 PHE D CE2 1 
ATOM   7311 C  CZ  . PHE D 2 72  ? -26.68  -14.984 33.504  1    42.41  ? 242 PHE D CZ  1 
ATOM   7312 N  N   . LEU D 2 73  ? -30.587 -18.188 30.396  1    47.9   ? 243 LEU D N   1 
ATOM   7313 C  CA  . LEU D 2 73  ? -30.045 -19.505 30.115  1    48.4   ? 243 LEU D CA  1 
ATOM   7314 C  C   . LEU D 2 73  ? -30.065 -19.813 28.614  1    49.47  ? 243 LEU D C   1 
ATOM   7315 O  O   . LEU D 2 73  ? -29.452 -20.797 28.185  1    49.97  ? 243 LEU D O   1 
ATOM   7316 C  CB  . LEU D 2 73  ? -30.85  -20.536 30.906  1    47.02  ? 243 LEU D CB  1 
ATOM   7317 C  CG  . LEU D 2 73  ? -30.742 -20.433 32.425  1    45.82  ? 243 LEU D CG  1 
ATOM   7318 C  CD1 . LEU D 2 73  ? -31.667 -21.465 33.054  1    48.58  ? 243 LEU D CD1 1 
ATOM   7319 C  CD2 . LEU D 2 73  ? -29.301 -20.613 32.894  1    42.98  ? 243 LEU D CD2 1 
ATOM   7320 N  N   . SER D 2 74  ? -30.772 -18.984 27.829  1    48.07  ? 244 SER D N   1 
ATOM   7321 C  CA  . SER D 2 74  ? -30.746 -19.07  26.372  1    50.69  ? 244 SER D CA  1 
ATOM   7322 C  C   . SER D 2 74  ? -29.421 -18.56  25.823  1    48.8   ? 244 SER D C   1 
ATOM   7323 O  O   . SER D 2 74  ? -29.053 -18.918 24.713  1    51.74  ? 244 SER D O   1 
ATOM   7324 C  CB  . SER D 2 74  ? -31.907 -18.342 25.724  1    49.34  ? 244 SER D CB  1 
ATOM   7325 O  OG  . SER D 2 74  ? -33.118 -19.046 25.972  1    51.11  ? 244 SER D OG  1 
ATOM   7326 N  N   . SER D 2 75  ? -28.705 -17.72  26.586  1    49.56  ? 245 SER D N   1 
ATOM   7327 C  CA  . SER D 2 75  ? -27.428 -17.216 26.085  1    53.3   ? 245 SER D CA  1 
ATOM   7328 C  C   . SER D 2 75  ? -26.25  -17.426 27.03   1    49.12  ? 245 SER D C   1 
ATOM   7329 O  O   . SER D 2 75  ? -25.13  -17.172 26.627  1    54.74  ? 245 SER D O   1 
ATOM   7330 C  CB  . SER D 2 75  ? -27.498 -15.79  25.598  1    54.07  ? 245 SER D CB  1 
ATOM   7331 O  OG  . SER D 2 75  ? -28.145 -14.978 26.559  1    60.16  ? 245 SER D OG  1 
ATOM   7332 N  N   . MET D 2 76  ? -26.467 -17.904 28.258  1    48.97  ? 246 MET D N   1 
ATOM   7333 C  CA  . MET D 2 76  ? -25.348 -18.064 29.195  1    48.31  ? 246 MET D CA  1 
ATOM   7334 C  C   . MET D 2 76  ? -25.289 -19.496 29.736  1    48.16  ? 246 MET D C   1 
ATOM   7335 O  O   . MET D 2 76  ? -26.268 -19.991 30.297  1    47.69  ? 246 MET D O   1 
ATOM   7336 C  CB  . MET D 2 76  ? -25.461 -17.114 30.392  1    44.99  ? 246 MET D CB  1 
ATOM   7337 C  CG  . MET D 2 76  ? -25.582 -15.662 30.014  1    50.16  ? 246 MET D CG  1 
ATOM   7338 S  SD  . MET D 2 76  ? -24.047 -14.97  29.371  1    52.84  ? 246 MET D SD  1 
ATOM   7339 C  CE  . MET D 2 76  ? -23.264 -14.852 30.986  1    47.5   ? 246 MET D CE  1 
ATOM   7340 N  N   . SER D 2 77  ? -24.132 -20.147 29.577  1    45.63  ? 247 SER D N   1 
ATOM   7341 C  CA  . SER D 2 77  ? -23.87  -21.39  30.283  1    47.63  ? 247 SER D CA  1 
ATOM   7342 C  C   . SER D 2 77  ? -23.815 -21.09  31.774  1    48.69  ? 247 SER D C   1 
ATOM   7343 O  O   . SER D 2 77  ? -23.134 -20.133 32.166  1    51.76  ? 247 SER D O   1 
ATOM   7344 C  CB  . SER D 2 77  ? -22.567 -22.021 29.846  1    49.61  ? 247 SER D CB  1 
ATOM   7345 O  OG  . SER D 2 77  ? -22.618 -22.356 28.463  1    57.3   ? 247 SER D OG  1 
ATOM   7346 N  N   . VAL D 2 78  ? -24.502 -21.925 32.579  1    47.39  ? 248 VAL D N   1 
ATOM   7347 C  CA  . VAL D 2 78  ? -24.493 -21.799 34.028  1    46.08  ? 248 VAL D CA  1 
ATOM   7348 C  C   . VAL D 2 78  ? -24.24  -23.159 34.654  1    47.4   ? 248 VAL D C   1 
ATOM   7349 O  O   . VAL D 2 78  ? -24.855 -24.126 34.238  1    55.69  ? 248 VAL D O   1 
ATOM   7350 C  CB  . VAL D 2 78  ? -25.823 -21.2   34.513  1    46.7   ? 248 VAL D CB  1 
ATOM   7351 C  CG1 . VAL D 2 78  ? -25.947 -21.258 36.03   1    44.63  ? 248 VAL D CG1 1 
ATOM   7352 C  CG2 . VAL D 2 78  ? -25.996 -19.761 34.023  1    44.71  ? 248 VAL D CG2 1 
ATOM   7353 N  N   . LEU D 2 79  ? -23.342 -23.222 35.641  1    48.3   ? 249 LEU D N   1 
ATOM   7354 C  CA  . LEU D 2 79  ? -23.154 -24.407 36.469  1    52.31  ? 249 LEU D CA  1 
ATOM   7355 C  C   . LEU D 2 79  ? -24.3   -24.55  37.477  1    51.52  ? 249 LEU D C   1 
ATOM   7356 O  O   . LEU D 2 79  ? -24.976 -23.585 37.846  1    46.86  ? 249 LEU D O   1 
ATOM   7357 C  CB  . LEU D 2 79  ? -21.795 -24.405 37.178  1    53.05  ? 249 LEU D CB  1 
ATOM   7358 C  CG  . LEU D 2 79  ? -20.571 -24.426 36.255  1    60.63  ? 249 LEU D CG  1 
ATOM   7359 C  CD1 . LEU D 2 79  ? -19.325 -24.814 37.024  1    61.53  ? 249 LEU D CD1 1 
ATOM   7360 C  CD2 . LEU D 2 79  ? -20.725 -25.262 34.967  1    58.63  ? 249 LEU D CD2 1 
ATOM   7361 N  N   . ARG D 2 80  ? -24.458 -25.777 37.962  1    52.88  ? 250 ARG D N   1 
ATOM   7362 C  CA  . ARG D 2 80  ? -25.594 -26.175 38.778  1    55.17  ? 250 ARG D CA  1 
ATOM   7363 C  C   . ARG D 2 80  ? -25.628 -25.375 40.078  1    53.73  ? 250 ARG D C   1 
ATOM   7364 O  O   . ARG D 2 80  ? -26.684 -24.926 40.489  1    53.58  ? 250 ARG D O   1 
ATOM   7365 C  CB  . ARG D 2 80  ? -25.422 -27.675 39.026  1    61.26  ? 250 ARG D CB  1 
ATOM   7366 C  CG  . ARG D 2 80  ? -26.629 -28.248 39.736  1    76.33  ? 250 ARG D CG  1 
ATOM   7367 C  CD  . ARG D 2 80  ? -26.518 -29.747 39.771  1    83.76  ? 250 ARG D CD  1 
ATOM   7368 N  NE  . ARG D 2 80  ? -25.275 -30.247 40.353  1    79.97  ? 250 ARG D NE  1 
ATOM   7369 C  CZ  . ARG D 2 80  ? -24.913 -31.529 40.256  1    93.27  ? 250 ARG D CZ  1 
ATOM   7370 N  NH1 . ARG D 2 80  ? -25.618 -32.419 39.54   1    82.86  ? 250 ARG D NH1 1 
ATOM   7371 N  NH2 . ARG D 2 80  ? -23.8   -31.906 40.865  1    96.92  ? 250 ARG D NH2 1 
ATOM   7372 N  N   . GLY D 2 81  ? -24.457 -25.147 40.685  1    52.21  ? 251 GLY D N   1 
ATOM   7373 C  CA  . GLY D 2 81  ? -24.333 -24.392 41.916  1    49.48  ? 251 GLY D CA  1 
ATOM   7374 C  C   . GLY D 2 81  ? -24.629 -22.899 41.763  1    52.33  ? 251 GLY D C   1 
ATOM   7375 O  O   . GLY D 2 81  ? -24.627 -22.166 42.754  1    53.5   ? 251 GLY D O   1 
ATOM   7376 N  N   . LYS D 2 82  ? -24.866 -22.435 40.528  1    48.47  ? 252 LYS D N   1 
ATOM   7377 C  CA  . LYS D 2 82  ? -25.142 -21.032 40.308  1    44.8   ? 252 LYS D CA  1 
ATOM   7378 C  C   . LYS D 2 82  ? -26.549 -20.839 39.769  1    44.11  ? 252 LYS D C   1 
ATOM   7379 O  O   . LYS D 2 82  ? -27.006 -19.705 39.636  1    43.69  ? 252 LYS D O   1 
ATOM   7380 C  CB  . LYS D 2 82  ? -24.101 -20.448 39.355  1    48.2   ? 252 LYS D CB  1 
ATOM   7381 C  CG  . LYS D 2 82  ? -22.691 -20.347 39.954  1    46.94  ? 252 LYS D CG  1 
ATOM   7382 C  CD  . LYS D 2 82  ? -22.788 -19.441 41.166  1    44.61  ? 252 LYS D CD  1 
ATOM   7383 C  CE  . LYS D 2 82  ? -21.447 -18.937 41.596  1    47.85  ? 252 LYS D CE  1 
ATOM   7384 N  NZ  . LYS D 2 82  ? -20.644 -20.01  42.173  1    48.76  ? 252 LYS D NZ  1 
ATOM   7385 N  N   . LEU D 2 83  ? -27.259 -21.937 39.502  1    44.35  ? 253 LEU D N   1 
ATOM   7386 C  CA  . LEU D 2 83  ? -28.603 -21.826 38.949  1    43.13  ? 253 LEU D CA  1 
ATOM   7387 C  C   . LEU D 2 83  ? -29.498 -21.002 39.878  1    43.68  ? 253 LEU D C   1 
ATOM   7388 O  O   . LEU D 2 83  ? -30.254 -20.15  39.413  1    42.55  ? 253 LEU D O   1 
ATOM   7389 C  CB  . LEU D 2 83  ? -29.172 -23.226 38.733  1    43.63  ? 253 LEU D CB  1 
ATOM   7390 C  CG  . LEU D 2 83  ? -30.569 -23.28  38.109  1    42.93  ? 253 LEU D CG  1 
ATOM   7391 C  CD1 . LEU D 2 83  ? -30.603 -22.567 36.749  1    39.93  ? 253 LEU D CD1 1 
ATOM   7392 C  CD2 . LEU D 2 83  ? -30.944 -24.773 37.977  1    43.88  ? 253 LEU D CD2 1 
ATOM   7393 N  N   . GLN D 2 84  ? -29.442 -21.296 41.185  1    42.97  ? 254 GLN D N   1 
ATOM   7394 C  CA  . GLN D 2 84  ? -30.259 -20.581 42.148  1    41.91  ? 254 GLN D CA  1 
ATOM   7395 C  C   . GLN D 2 84  ? -29.869 -19.102 42.214  1    43.31  ? 254 GLN D C   1 
ATOM   7396 O  O   . GLN D 2 84  ? -30.713 -18.248 42.499  1    42.39  ? 254 GLN D O   1 
ATOM   7397 C  CB  . GLN D 2 84  ? -30.14  -21.221 43.526  1    42.27  ? 254 GLN D CB  1 
ATOM   7398 C  CG  . GLN D 2 84  ? -31.231 -20.755 44.483  1    43.02  ? 254 GLN D CG  1 
ATOM   7399 C  CD  . GLN D 2 84  ? -31.097 -21.353 45.87   1    50.37  ? 254 GLN D CD  1 
ATOM   7400 O  OE1 . GLN D 2 84  ? -31.978 -21.155 46.714  1    54.94  ? 254 GLN D OE1 1 
ATOM   7401 N  NE2 . GLN D 2 84  ? -30.025 -22.099 46.126  1    48.95  ? 254 GLN D NE2 1 
ATOM   7402 N  N   . LEU D 2 85  ? -28.584 -18.799 41.961  1    43.4   ? 255 LEU D N   1 
ATOM   7403 C  CA  . LEU D 2 85  ? -28.137 -17.418 41.98   1    41.55  ? 255 LEU D CA  1 
ATOM   7404 C  C   . LEU D 2 85  ? -28.822 -16.639 40.862  1    39.44  ? 255 LEU D C   1 
ATOM   7405 O  O   . LEU D 2 85  ? -29.315 -15.561 41.1    1    43.22  ? 255 LEU D O   1 
ATOM   7406 C  CB  . LEU D 2 85  ? -26.619 -17.351 41.894  1    40.56  ? 255 LEU D CB  1 
ATOM   7407 C  CG  . LEU D 2 85  ? -26.05  -15.938 41.949  1    41.59  ? 255 LEU D CG  1 
ATOM   7408 C  CD1 . LEU D 2 85  ? -26.464 -15.192 43.212  1    40.39  ? 255 LEU D CD1 1 
ATOM   7409 C  CD2 . LEU D 2 85  ? -24.55  -15.979 41.796  1    41.83  ? 255 LEU D CD2 1 
ATOM   7410 N  N   . VAL D 2 86  ? -28.882 -17.216 39.663  1    40.25  ? 256 VAL D N   1 
ATOM   7411 C  CA  . VAL D 2 86  ? -29.542 -16.624 38.512  1    40.43  ? 256 VAL D CA  1 
ATOM   7412 C  C   . VAL D 2 86  ? -31.026 -16.387 38.832  1    44.1   ? 256 VAL D C   1 
ATOM   7413 O  O   . VAL D 2 86  ? -31.566 -15.312 38.554  1    42.65  ? 256 VAL D O   1 
ATOM   7414 C  CB  . VAL D 2 86  ? -29.383 -17.521 37.264  1    38.26  ? 256 VAL D CB  1 
ATOM   7415 C  CG1 . VAL D 2 86  ? -30.261 -17.033 36.11   1    36.1   ? 256 VAL D CG1 1 
ATOM   7416 C  CG2 . VAL D 2 86  ? -27.924 -17.677 36.838  1    38.14  ? 256 VAL D CG2 1 
ATOM   7417 N  N   . GLY D 2 87  ? -31.684 -17.405 39.407  1    44.01  ? 257 GLY D N   1 
ATOM   7418 C  CA  . GLY D 2 87  ? -33.089 -17.323 39.777  1    45.68  ? 257 GLY D CA  1 
ATOM   7419 C  C   . GLY D 2 87  ? -33.381 -16.234 40.818  1    47.37  ? 257 GLY D C   1 
ATOM   7420 O  O   . GLY D 2 87  ? -34.37  -15.504 40.681  1    48.97  ? 257 GLY D O   1 
ATOM   7421 N  N   . THR D 2 88  ? -32.543 -16.138 41.863  1    42.91  ? 258 THR D N   1 
ATOM   7422 C  CA  . THR D 2 88  ? -32.75  -15.145 42.913  1    44.11  ? 258 THR D CA  1 
ATOM   7423 C  C   . THR D 2 88  ? -32.631 -13.75  42.297  1    44.02  ? 258 THR D C   1 
ATOM   7424 O  O   . THR D 2 88  ? -33.455 -12.877 42.561  1    42.58  ? 258 THR D O   1 
ATOM   7425 C  CB  . THR D 2 88  ? -31.752 -15.332 44.063  1    42.37  ? 258 THR D CB  1 
ATOM   7426 O  OG1 . THR D 2 88  ? -31.816 -16.686 44.487  1    48.42  ? 258 THR D OG1 1 
ATOM   7427 C  CG2 . THR D 2 88  ? -32.101 -14.52  45.288  1    41.5   ? 258 THR D CG2 1 
ATOM   7428 N  N   . ALA D 2 89  ? -31.615 -13.566 41.446  1    43.25  ? 259 ALA D N   1 
ATOM   7429 C  CA  . ALA D 2 89  ? -31.396 -12.271 40.818  1    45.03  ? 259 ALA D CA  1 
ATOM   7430 C  C   . ALA D 2 89  ? -32.56  -11.945 39.9    1    42.51  ? 259 ALA D C   1 
ATOM   7431 O  O   . ALA D 2 89  ? -33.016 -10.805 39.874  1    43.26  ? 259 ALA D O   1 
ATOM   7432 C  CB  . ALA D 2 89  ? -30.072 -12.23  40.096  1    42.19  ? 259 ALA D CB  1 
ATOM   7433 N  N   . ALA D 2 90  ? -33.06  -12.966 39.204  1    40.58  ? 260 ALA D N   1 
ATOM   7434 C  CA  . ALA D 2 90  ? -34.203 -12.785 38.32   1    43.96  ? 260 ALA D CA  1 
ATOM   7435 C  C   . ALA D 2 90  ? -35.423 -12.299 39.111  1    44.17  ? 260 ALA D C   1 
ATOM   7436 O  O   . ALA D 2 90  ? -36.112 -11.355 38.698  1    43.26  ? 260 ALA D O   1 
ATOM   7437 C  CB  . ALA D 2 90  ? -34.482 -14.095 37.591  1    45.18  ? 260 ALA D CB  1 
ATOM   7438 N  N   . MET D 2 91  ? -35.679 -12.963 40.246  1    41.18  ? 261 MET D N   1 
ATOM   7439 C  CA  . MET D 2 91  ? -36.825 -12.667 41.097  1    42.28  ? 261 MET D CA  1 
ATOM   7440 C  C   . MET D 2 91  ? -36.676 -11.244 41.631  1    43.13  ? 261 MET D C   1 
ATOM   7441 O  O   . MET D 2 91  ? -37.641 -10.482 41.631  1    42.43  ? 261 MET D O   1 
ATOM   7442 C  CB  . MET D 2 91  ? -36.893 -13.666 42.259  1    42.71  ? 261 MET D CB  1 
ATOM   7443 C  CG  . MET D 2 91  ? -38.243 -13.833 42.903  1    48.52  ? 261 MET D CG  1 
ATOM   7444 S  SD  . MET D 2 91  ? -39.563 -14.237 41.743  1    53.01  ? 261 MET D SD  1 
ATOM   7445 C  CE  . MET D 2 91  ? -40.881 -14.626 42.883  1    49.83  ? 261 MET D CE  1 
ATOM   7446 N  N   . LEU D 2 92  ? -35.44  -10.877 42.016  1    39.96  ? 262 LEU D N   1 
ATOM   7447 C  CA  . LEU D 2 92  ? -35.159 -9.536  42.485  1    41.63  ? 262 LEU D CA  1 
ATOM   7448 C  C   . LEU D 2 92  ? -35.54  -8.522  41.404  1    42.61  ? 262 LEU D C   1 
ATOM   7449 O  O   . LEU D 2 92  ? -36.283 -7.572  41.652  1    44.08  ? 262 LEU D O   1 
ATOM   7450 C  CB  . LEU D 2 92  ? -33.689 -9.422  42.889  1    41.11  ? 262 LEU D CB  1 
ATOM   7451 C  CG  . LEU D 2 92  ? -33.215 -8.012  43.265  1    40.66  ? 262 LEU D CG  1 
ATOM   7452 C  CD1 . LEU D 2 92  ? -34.041 -7.405  44.401  1    40.56  ? 262 LEU D CD1 1 
ATOM   7453 C  CD2 . LEU D 2 92  ? -31.75  -7.998  43.639  1    39.44  ? 262 LEU D CD2 1 
ATOM   7454 N  N   . LEU D 2 93  ? -35.041 -8.745  40.183  1    40.86  ? 263 LEU D N   1 
ATOM   7455 C  CA  . LEU D 2 93  ? -35.266 -7.808  39.105  1    37.14  ? 263 LEU D CA  1 
ATOM   7456 C  C   . LEU D 2 93  ? -36.752 -7.711  38.792  1    39.82  ? 263 LEU D C   1 
ATOM   7457 O  O   . LEU D 2 93  ? -37.248 -6.597  38.603  1    43.16  ? 263 LEU D O   1 
ATOM   7458 C  CB  . LEU D 2 93  ? -34.472 -8.254  37.89   1    36.8   ? 263 LEU D CB  1 
ATOM   7459 C  CG  . LEU D 2 93  ? -32.983 -7.884  37.898  1    37.95  ? 263 LEU D CG  1 
ATOM   7460 C  CD1 . LEU D 2 93  ? -32.323 -8.602  36.704  1    34.68  ? 263 LEU D CD1 1 
ATOM   7461 C  CD2 . LEU D 2 93  ? -32.8   -6.354  37.784  1    39.31  ? 263 LEU D CD2 1 
ATOM   7462 N  N   . ALA D 2 94  ? -37.432 -8.864  38.696  1    37.62  ? 264 ALA D N   1 
ATOM   7463 C  CA  . ALA D 2 94  ? -38.871 -8.888  38.469  1    38.69  ? 264 ALA D CA  1 
ATOM   7464 C  C   . ALA D 2 94  ? -39.591 -8.071  39.538  1    42.4   ? 264 ALA D C   1 
ATOM   7465 O  O   . ALA D 2 94  ? -40.49  -7.294  39.207  1    44.18  ? 264 ALA D O   1 
ATOM   7466 C  CB  . ALA D 2 94  ? -39.379 -10.303 38.436  1    36.99  ? 264 ALA D CB  1 
ATOM   7467 N  N   . SER D 2 95  ? -39.168 -8.224  40.805  1    39.9   ? 265 SER D N   1 
ATOM   7468 C  CA  . SER D 2 95  ? -39.791 -7.532  41.921  1    41.58  ? 265 SER D CA  1 
ATOM   7469 C  C   . SER D 2 95  ? -39.653 -6.02   41.759  1    42.43  ? 265 SER D C   1 
ATOM   7470 O  O   . SER D 2 95  ? -40.633 -5.278  41.882  1    46.89  ? 265 SER D O   1 
ATOM   7471 C  CB  . SER D 2 95  ? -39.209 -7.98   43.249  1    41.47  ? 265 SER D CB  1 
ATOM   7472 O  OG  . SER D 2 95  ? -39.458 -9.363  43.441  1    44.95  ? 265 SER D OG  1 
ATOM   7473 N  N   . LYS D 2 96  ? -38.429 -5.57   41.475  1    39.56  ? 266 LYS D N   1 
ATOM   7474 C  CA  . LYS D 2 96  ? -38.181 -4.156  41.229  1    39.48  ? 266 LYS D CA  1 
ATOM   7475 C  C   . LYS D 2 96  ? -39.005 -3.647  40.05   1    38.95  ? 266 LYS D C   1 
ATOM   7476 O  O   . LYS D 2 96  ? -39.472 -2.524  40.108  1    42.03  ? 266 LYS D O   1 
ATOM   7477 C  CB  . LYS D 2 96  ? -36.689 -3.906  41.004  1    39.47  ? 266 LYS D CB  1 
ATOM   7478 C  CG  . LYS D 2 96  ? -35.864 -3.958  42.291  1    38.88  ? 266 LYS D CG  1 
ATOM   7479 C  CD  . LYS D 2 96  ? -34.39  -3.766  41.937  1    40.56  ? 266 LYS D CD  1 
ATOM   7480 C  CE  . LYS D 2 96  ? -33.484 -3.633  43.148  1    41.33  ? 266 LYS D CE  1 
ATOM   7481 N  NZ  . LYS D 2 96  ? -32.078 -3.569  42.719  1    43.06  ? 266 LYS D NZ  1 
ATOM   7482 N  N   . PHE D 2 97  ? -39.194 -4.465  38.999  1    37.52  ? 267 PHE D N   1 
ATOM   7483 C  CA  . PHE D 2 97  ? -39.933 -4.033  37.835  1    38.07  ? 267 PHE D CA  1 
ATOM   7484 C  C   . PHE D 2 97  ? -41.411 -3.847  38.203  1    42.82  ? 267 PHE D C   1 
ATOM   7485 O  O   . PHE D 2 97  ? -42.01  -2.808  37.904  1    40.19  ? 267 PHE D O   1 
ATOM   7486 C  CB  . PHE D 2 97  ? -39.694 -4.96   36.641  1    37     ? 267 PHE D CB  1 
ATOM   7487 C  CG  . PHE D 2 97  ? -40.451 -4.548  35.386  1    39.56  ? 267 PHE D CG  1 
ATOM   7488 C  CD1 . PHE D 2 97  ? -39.899 -3.629  34.48   1    41.61  ? 267 PHE D CD1 1 
ATOM   7489 C  CD2 . PHE D 2 97  ? -41.74  -5.038  35.121  1    39.32  ? 267 PHE D CD2 1 
ATOM   7490 C  CE1 . PHE D 2 97  ? -40.625 -3.223  33.339  1    40.84  ? 267 PHE D CE1 1 
ATOM   7491 C  CE2 . PHE D 2 97  ? -42.436 -4.65   33.96   1    39.76  ? 267 PHE D CE2 1 
ATOM   7492 C  CZ  . PHE D 2 97  ? -41.89  -3.743  33.071  1    38.16  ? 267 PHE D CZ  1 
ATOM   7493 N  N   . GLU D 2 98  ? -41.971 -4.842  38.913  1    45.74  ? 268 GLU D N   1 
ATOM   7494 C  CA  . GLU D 2 98  ? -43.412 -5.043  38.956  1    44.22  ? 268 GLU D CA  1 
ATOM   7495 C  C   . GLU D 2 98  ? -44.019 -4.637  40.292  1    44.6   ? 268 GLU D C   1 
ATOM   7496 O  O   . GLU D 2 98  ? -45.133 -4.143  40.301  1    51.16  ? 268 GLU D O   1 
ATOM   7497 C  CB  . GLU D 2 98  ? -43.718 -6.51   38.689  1    44.97  ? 268 GLU D CB  1 
ATOM   7498 C  CG  . GLU D 2 98  ? -45.182 -6.811  38.373  1    48.47  ? 268 GLU D CG  1 
ATOM   7499 C  CD  . GLU D 2 98  ? -45.775 -6.031  37.223  1    50.52  ? 268 GLU D CD  1 
ATOM   7500 O  OE1 . GLU D 2 98  ? -45.019 -5.728  36.273  1    49.05  ? 268 GLU D OE1 1 
ATOM   7501 O  OE2 . GLU D 2 98  ? -46.994 -5.759  37.272  1    51.15  ? 268 GLU D OE2 1 
ATOM   7502 N  N   . GLU D 2 99  ? -43.328 -4.866  41.414  1    44.3   ? 269 GLU D N   1 
ATOM   7503 C  CA  . GLU D 2 99  ? -43.949 -4.705  42.727  1    42.31  ? 269 GLU D CA  1 
ATOM   7504 C  C   . GLU D 2 99  ? -43.939 -3.243  43.153  1    45.9   ? 269 GLU D C   1 
ATOM   7505 O  O   . GLU D 2 99  ? -42.992 -2.517  42.878  1    49.74  ? 269 GLU D O   1 
ATOM   7506 C  CB  . GLU D 2 99  ? -43.168 -5.481  43.783  1    40.18  ? 269 GLU D CB  1 
ATOM   7507 C  CG  . GLU D 2 99  ? -43.257 -6.993  43.609  1    42.18  ? 269 GLU D CG  1 
ATOM   7508 C  CD  . GLU D 2 99  ? -44.639 -7.576  43.895  1    47.92  ? 269 GLU D CD  1 
ATOM   7509 O  OE1 . GLU D 2 99  ? -45.342 -7.172  44.879  1    49.25  ? 269 GLU D OE1 1 
ATOM   7510 O  OE2 . GLU D 2 99  ? -45.005 -8.469  43.113  1    46.29  ? 269 GLU D OE2 1 
ATOM   7511 N  N   . ILE D 2 100 ? -44.974 -2.839  43.893  1    48.31  ? 270 ILE D N   1 
ATOM   7512 C  CA  . ILE D 2 100 ? -45.042 -1.521  44.496  1    49.32  ? 270 ILE D CA  1 
ATOM   7513 C  C   . ILE D 2 100 ? -44.022 -1.445  45.625  1    54.42  ? 270 ILE D C   1 
ATOM   7514 O  O   . ILE D 2 100 ? -43.32  -0.435  45.759  1    59.52  ? 270 ILE D O   1 
ATOM   7515 C  CB  . ILE D 2 100 ? -46.456 -1.237  45.032  1    47.79  ? 270 ILE D CB  1 
ATOM   7516 C  CG1 . ILE D 2 100 ? -47.471 -1.132  43.902  1    48.39  ? 270 ILE D CG1 1 
ATOM   7517 C  CG2 . ILE D 2 100 ? -46.469 0.017   45.909  1    46.51  ? 270 ILE D CG2 1 
ATOM   7518 C  CD1 . ILE D 2 100 ? -48.921 -1.036  44.365  1    49.9   ? 270 ILE D CD1 1 
ATOM   7519 N  N   . TYR D 2 101 ? -43.997 -2.513  46.44   1    56.07  ? 271 TYR D N   1 
ATOM   7520 C  CA  . TYR D 2 101 ? -43.129 -2.622  47.609  1    54.99  ? 271 TYR D CA  1 
ATOM   7521 C  C   . TYR D 2 101 ? -42.26  -3.878  47.484  1    52.51  ? 271 TYR D C   1 
ATOM   7522 O  O   . TYR D 2 101 ? -42.532 -4.899  48.118  1    54.99  ? 271 TYR D O   1 
ATOM   7523 C  CB  . TYR D 2 101 ? -44.014 -2.789  48.843  1    52.27  ? 271 TYR D CB  1 
ATOM   7524 C  CG  . TYR D 2 101 ? -44.939 -1.622  49.113  1    53.69  ? 271 TYR D CG  1 
ATOM   7525 C  CD1 . TYR D 2 101 ? -44.419 -0.386  49.539  1    53.22  ? 271 TYR D CD1 1 
ATOM   7526 C  CD2 . TYR D 2 101 ? -46.333 -1.772  48.984  1    53.97  ? 271 TYR D CD2 1 
ATOM   7527 C  CE1 . TYR D 2 101 ? -45.269 0.672   49.817  1    54.04  ? 271 TYR D CE1 1 
ATOM   7528 C  CE2 . TYR D 2 101 ? -47.184 -0.704  49.252  1    54.77  ? 271 TYR D CE2 1 
ATOM   7529 C  CZ  . TYR D 2 101 ? -46.646 0.504   49.679  1    57.44  ? 271 TYR D CZ  1 
ATOM   7530 O  OH  . TYR D 2 101 ? -47.491 1.547   49.943  1    71.79  ? 271 TYR D OH  1 
ATOM   7531 N  N   . PRO D 2 102 ? -41.188 -3.86   46.658  1    48.54  ? 272 PRO D N   1 
ATOM   7532 C  CA  . PRO D 2 102 ? -40.375 -5.063  46.468  1    45.63  ? 272 PRO D CA  1 
ATOM   7533 C  C   . PRO D 2 102 ? -39.683 -5.438  47.779  1    45.13  ? 272 PRO D C   1 
ATOM   7534 O  O   . PRO D 2 102 ? -39.386 -4.588  48.626  1    46.58  ? 272 PRO D O   1 
ATOM   7535 C  CB  . PRO D 2 102 ? -39.395 -4.644  45.372  1    41.93  ? 272 PRO D CB  1 
ATOM   7536 C  CG  . PRO D 2 102 ? -39.289 -3.161  45.54   1    41.66  ? 272 PRO D CG  1 
ATOM   7537 C  CD  . PRO D 2 102 ? -40.689 -2.691  45.912  1    44.26  ? 272 PRO D CD  1 
ATOM   7538 N  N   . PRO D 2 103 ? -39.423 -6.734  48.024  1    45.14  ? 273 PRO D N   1 
ATOM   7539 C  CA  . PRO D 2 103 ? -38.601 -7.096  49.171  1    47.72  ? 273 PRO D CA  1 
ATOM   7540 C  C   . PRO D 2 103 ? -37.226 -6.47   48.92   1    50.99  ? 273 PRO D C   1 
ATOM   7541 O  O   . PRO D 2 103 ? -36.818 -6.226  47.782  1    50.01  ? 273 PRO D O   1 
ATOM   7542 C  CB  . PRO D 2 103 ? -38.564 -8.616  49.147  1    45.71  ? 273 PRO D CB  1 
ATOM   7543 C  CG  . PRO D 2 103 ? -39.672 -9.02   48.187  1    48.56  ? 273 PRO D CG  1 
ATOM   7544 C  CD  . PRO D 2 103 ? -39.864 -7.881  47.211  1    45.73  ? 273 PRO D CD  1 
ATOM   7545 N  N   . GLU D 2 104 ? -36.517 -6.186  50.007  1    53.38  ? 274 GLU D N   1 
ATOM   7546 C  CA  . GLU D 2 104 ? -35.163 -5.681  49.924  1    59.49  ? 274 GLU D CA  1 
ATOM   7547 C  C   . GLU D 2 104 ? -34.207 -6.786  49.499  1    56.43  ? 274 GLU D C   1 
ATOM   7548 O  O   . GLU D 2 104 ? -34.557 -7.968  49.591  1    55.25  ? 274 GLU D O   1 
ATOM   7549 C  CB  . GLU D 2 104 ? -34.831 -5.12   51.301  1    62.57  ? 274 GLU D CB  1 
ATOM   7550 C  CG  . GLU D 2 104 ? -35.242 -3.656  51.354  1    73.56  ? 274 GLU D CG  1 
ATOM   7551 C  CD  . GLU D 2 104 ? -35.192 -3.105  52.754  1    86     ? 274 GLU D CD  1 
ATOM   7552 O  OE1 . GLU D 2 104 ? -35.353 -1.876  52.873  1    100.58 ? 274 GLU D OE1 1 
ATOM   7553 O  OE2 . GLU D 2 104 ? -34.963 -3.899  53.698  1    91.5   ? 274 GLU D OE2 1 
ATOM   7554 N  N   . VAL D 2 105 ? -33.001 -6.378  49.085  1    52.27  ? 275 VAL D N   1 
ATOM   7555 C  CA  . VAL D 2 105 ? -31.988 -7.316  48.607  1    49.76  ? 275 VAL D CA  1 
ATOM   7556 C  C   . VAL D 2 105 ? -31.665 -8.333  49.701  1    48.26  ? 275 VAL D C   1 
ATOM   7557 O  O   . VAL D 2 105 ? -31.512 -9.514  49.422  1    48.6   ? 275 VAL D O   1 
ATOM   7558 C  CB  . VAL D 2 105 ? -30.709 -6.625  48.081  1    48.9   ? 275 VAL D CB  1 
ATOM   7559 C  CG1 . VAL D 2 105 ? -29.649 -7.623  47.674  1    51.67  ? 275 VAL D CG1 1 
ATOM   7560 C  CG2 . VAL D 2 105 ? -30.968 -5.749  46.866  1    45.31  ? 275 VAL D CG2 1 
ATOM   7561 N  N   . ALA D 2 106 ? -31.637 -7.885  50.957  1    49.48  ? 276 ALA D N   1 
ATOM   7562 C  CA  . ALA D 2 106 ? -31.313 -8.756  52.08   1    50.43  ? 276 ALA D CA  1 
ATOM   7563 C  C   . ALA D 2 106 ? -32.29  -9.924  52.186  1    51.66  ? 276 ALA D C   1 
ATOM   7564 O  O   . ALA D 2 106 ? -31.886 -11.01  52.608  1    53.63  ? 276 ALA D O   1 
ATOM   7565 C  CB  . ALA D 2 106 ? -31.21  -7.992  53.386  1    46.84  ? 276 ALA D CB  1 
ATOM   7566 N  N   . GLU D 2 107 ? -33.556 -9.692  51.818  1    50.53  ? 277 GLU D N   1 
ATOM   7567 C  CA  . GLU D 2 107 ? -34.543 -10.763 51.831  1    54.4   ? 277 GLU D CA  1 
ATOM   7568 C  C   . GLU D 2 107 ? -34.221 -11.79  50.749  1    55.49  ? 277 GLU D C   1 
ATOM   7569 O  O   . GLU D 2 107 ? -34.434 -12.986 50.93   1    59.37  ? 277 GLU D O   1 
ATOM   7570 C  CB  . GLU D 2 107 ? -35.959 -10.225 51.641  1    58.36  ? 277 GLU D CB  1 
ATOM   7571 C  CG  . GLU D 2 107 ? -36.397 -9.266  52.747  1    63.75  ? 277 GLU D CG  1 
ATOM   7572 C  CD  . GLU D 2 107 ? -36.771 -9.97   54.041  1    80.6   ? 277 GLU D CD  1 
ATOM   7573 O  OE1 . GLU D 2 107 ? -37.779 -9.574  54.669  1    104    ? 277 GLU D OE1 1 
ATOM   7574 O  OE2 . GLU D 2 107 ? -36.093 -10.947 54.422  1    81.73  ? 277 GLU D OE2 1 
ATOM   7575 N  N   . PHE D 2 108 ? -33.676 -11.329 49.616  1    54.78  ? 278 PHE D N   1 
ATOM   7576 C  CA  . PHE D 2 108 ? -33.342 -12.252 48.549  1    51.94  ? 278 PHE D CA  1 
ATOM   7577 C  C   . PHE D 2 108 ? -32.129 -13.096 48.938  1    54.2   ? 278 PHE D C   1 
ATOM   7578 O  O   . PHE D 2 108 ? -32.005 -14.232 48.473  1    56.52  ? 278 PHE D O   1 
ATOM   7579 C  CB  . PHE D 2 108 ? -33.162 -11.506 47.229  1    48.31  ? 278 PHE D CB  1 
ATOM   7580 C  CG  . PHE D 2 108 ? -34.498 -11.103 46.651  1    46.99  ? 278 PHE D CG  1 
ATOM   7581 C  CD1 . PHE D 2 108 ? -35.265 -12.03  45.933  1    44.66  ? 278 PHE D CD1 1 
ATOM   7582 C  CD2 . PHE D 2 108 ? -34.975 -9.809  46.808  1    44.51  ? 278 PHE D CD2 1 
ATOM   7583 C  CE1 . PHE D 2 108 ? -36.494 -11.673 45.395  1    40.64  ? 278 PHE D CE1 1 
ATOM   7584 C  CE2 . PHE D 2 108 ? -36.218 -9.466  46.264  1    46.1   ? 278 PHE D CE2 1 
ATOM   7585 C  CZ  . PHE D 2 108 ? -36.976 -10.402 45.557  1    40.44  ? 278 PHE D CZ  1 
ATOM   7586 N  N   . VAL D 2 109 ? -31.24  -12.535 49.765  1    49.42  ? 279 VAL D N   1 
ATOM   7587 C  CA  . VAL D 2 109 ? -30.112 -13.293 50.275  1    54.65  ? 279 VAL D CA  1 
ATOM   7588 C  C   . VAL D 2 109 ? -30.608 -14.334 51.28   1    59.46  ? 279 VAL D C   1 
ATOM   7589 O  O   . VAL D 2 109 ? -30.141 -15.471 51.283  1    63.28  ? 279 VAL D O   1 
ATOM   7590 C  CB  . VAL D 2 109 ? -29.024 -12.41  50.923  1    52.69  ? 279 VAL D CB  1 
ATOM   7591 C  CG1 . VAL D 2 109 ? -27.912 -13.257 51.547  1    47.63  ? 279 VAL D CG1 1 
ATOM   7592 C  CG2 . VAL D 2 109 ? -28.455 -11.383 49.945  1    46.89  ? 279 VAL D CG2 1 
ATOM   7593 N  N   . TYR D 2 110 ? -31.511 -13.909 52.17   1    60.17  ? 280 TYR D N   1 
ATOM   7594 C  CA  . TYR D 2 110 ? -32.033 -14.745 53.234  1    56.79  ? 280 TYR D CA  1 
ATOM   7595 C  C   . TYR D 2 110 ? -32.646 -16.017 52.658  1    56.61  ? 280 TYR D C   1 
ATOM   7596 O  O   . TYR D 2 110 ? -32.344 -17.098 53.143  1    59.46  ? 280 TYR D O   1 
ATOM   7597 C  CB  . TYR D 2 110 ? -33.046 -13.936 54.046  1    62.5   ? 280 TYR D CB  1 
ATOM   7598 C  CG  . TYR D 2 110 ? -33.67  -14.74  55.172  1    69.77  ? 280 TYR D CG  1 
ATOM   7599 C  CD1 . TYR D 2 110 ? -32.983 -14.946 56.366  1    71.91  ? 280 TYR D CD1 1 
ATOM   7600 C  CD2 . TYR D 2 110 ? -34.934 -15.308 55.023  1    73.7   ? 280 TYR D CD2 1 
ATOM   7601 C  CE1 . TYR D 2 110 ? -33.547 -15.673 57.398  1    76.83  ? 280 TYR D CE1 1 
ATOM   7602 C  CE2 . TYR D 2 110 ? -35.488 -16.073 56.034  1    75.29  ? 280 TYR D CE2 1 
ATOM   7603 C  CZ  . TYR D 2 110 ? -34.802 -16.237 57.223  1    78.2   ? 280 TYR D CZ  1 
ATOM   7604 O  OH  . TYR D 2 110 ? -35.383 -16.988 58.198  1    89.06  ? 280 TYR D OH  1 
ATOM   7605 N  N   . ILE D 2 111 ? -33.451 -15.909 51.59   1    55.55  ? 281 ILE D N   1 
ATOM   7606 C  CA  . ILE D 2 111 ? -34.122 -17.077 51.03   1    58.52  ? 281 ILE D CA  1 
ATOM   7607 C  C   . ILE D 2 111 ? -33.187 -18.119 50.391  1    60.41  ? 281 ILE D C   1 
ATOM   7608 O  O   . ILE D 2 111 ? -33.649 -19.204 50.029  1    62.5   ? 281 ILE D O   1 
ATOM   7609 C  CB  . ILE D 2 111 ? -35.224 -16.678 50.039  1    56.75  ? 281 ILE D CB  1 
ATOM   7610 C  CG1 . ILE D 2 111 ? -34.646 -15.866 48.877  1    52.86  ? 281 ILE D CG1 1 
ATOM   7611 C  CG2 . ILE D 2 111 ? -36.374 -15.968 50.759  1    55.4   ? 281 ILE D CG2 1 
ATOM   7612 C  CD1 . ILE D 2 111 ? -35.64  -15.587 47.759  1    51.25  ? 281 ILE D CD1 1 
ATOM   7613 N  N   . THR D 2 112 ? -31.893 -17.81  50.202  1    58.99  ? 282 THR D N   1 
ATOM   7614 C  CA  . THR D 2 112 ? -30.978 -18.783 49.614  1    61.17  ? 282 THR D CA  1 
ATOM   7615 C  C   . THR D 2 112 ? -30.154 -19.491 50.688  1    66.42  ? 282 THR D C   1 
ATOM   7616 O  O   . THR D 2 112 ? -29.14  -20.105 50.334  1    65.49  ? 282 THR D O   1 
ATOM   7617 C  CB  . THR D 2 112 ? -30.041 -18.161 48.572  1    58.37  ? 282 THR D CB  1 
ATOM   7618 O  OG1 . THR D 2 112 ? -29.021 -17.448 49.266  1    58.07  ? 282 THR D OG1 1 
ATOM   7619 C  CG2 . THR D 2 112 ? -30.744 -17.267 47.575  1    50.74  ? 282 THR D CG2 1 
ATOM   7620 N  N   . ASP D 2 113 ? -30.567 -19.367 51.97   1    71.77  ? 283 ASP D N   1 
ATOM   7621 C  CA  . ASP D 2 113 ? -29.918 -19.973 53.127  1    80.25  ? 283 ASP D CA  1 
ATOM   7622 C  C   . ASP D 2 113 ? -28.424 -19.641 53.186  1    81.31  ? 283 ASP D C   1 
ATOM   7623 O  O   . ASP D 2 113 ? -27.612 -20.483 53.586  1    72.48  ? 283 ASP D O   1 
ATOM   7624 C  CB  . ASP D 2 113 ? -30.043 -21.493 53.15   1    98.04  ? 283 ASP D CB  1 
ATOM   7625 C  CG  . ASP D 2 113 ? -31.429 -22.068 53.396  1    112.18 ? 283 ASP D CG  1 
ATOM   7626 O  OD1 . ASP D 2 113 ? -32.035 -21.706 54.422  1    113.04 ? 283 ASP D OD1 1 
ATOM   7627 O  OD2 . ASP D 2 113 ? -31.87  -22.89  52.564  1    122.61 ? 283 ASP D OD2 1 
ATOM   7628 N  N   . ASP D 2 114 ? -28.057 -18.41  52.804  1    87.01  ? 284 ASP D N   1 
ATOM   7629 C  CA  . ASP D 2 114 ? -26.65  -18.031 52.744  1    94.77  ? 284 ASP D CA  1 
ATOM   7630 C  C   . ASP D 2 114 ? -25.824 -19.019 51.903  1    83.64  ? 284 ASP D C   1 
ATOM   7631 O  O   . ASP D 2 114 ? -24.615 -19.142 52.098  1    77.86  ? 284 ASP D O   1 
ATOM   7632 C  CB  . ASP D 2 114 ? -26.1   -17.731 54.135  1    111.23 ? 284 ASP D CB  1 
ATOM   7633 C  CG  . ASP D 2 114 ? -26.963 -16.8   54.983  1    112.97 ? 284 ASP D CG  1 
ATOM   7634 O  OD1 . ASP D 2 114 ? -27.473 -15.789 54.425  1    105.78 ? 284 ASP D OD1 1 
ATOM   7635 O  OD2 . ASP D 2 114 ? -27.111 -17.082 56.198  1    109.12 ? 284 ASP D OD2 1 
ATOM   7636 N  N   . THR D 2 115 ? -26.46  -19.696 50.928  1    76.48  ? 285 THR D N   1 
ATOM   7637 C  CA  . THR D 2 115 ? -25.718 -20.298 49.823  1    70.78  ? 285 THR D CA  1 
ATOM   7638 C  C   . THR D 2 115 ? -24.878 -19.22  49.123  1    67.15  ? 285 THR D C   1 
ATOM   7639 O  O   . THR D 2 115 ? -23.763 -19.49  48.682  1    63.64  ? 285 THR D O   1 
ATOM   7640 C  CB  . THR D 2 115 ? -26.638 -20.96  48.798  1    66.55  ? 285 THR D CB  1 
ATOM   7641 O  OG1 . THR D 2 115 ? -27.535 -21.875 49.419  1    66.77  ? 285 THR D OG1 1 
ATOM   7642 C  CG2 . THR D 2 115 ? -25.837 -21.667 47.721  1    62.37  ? 285 THR D CG2 1 
ATOM   7643 N  N   . TYR D 2 116 ? -25.434 -18.001 49.016  1    57.41  ? 286 TYR D N   1 
ATOM   7644 C  CA  . TYR D 2 116 ? -24.827 -16.916 48.268  1    55.49  ? 286 TYR D CA  1 
ATOM   7645 C  C   . TYR D 2 116 ? -24.716 -15.682 49.151  1    57.28  ? 286 TYR D C   1 
ATOM   7646 O  O   . TYR D 2 116 ? -25.564 -15.467 50.012  1    64.92  ? 286 TYR D O   1 
ATOM   7647 C  CB  . TYR D 2 116 ? -25.613 -16.566 46.996  1    47.98  ? 286 TYR D CB  1 
ATOM   7648 C  CG  . TYR D 2 116 ? -25.862 -17.744 46.062  1    48.81  ? 286 TYR D CG  1 
ATOM   7649 C  CD1 . TYR D 2 116 ? -24.811 -18.447 45.442  1    49.55  ? 286 TYR D CD1 1 
ATOM   7650 C  CD2 . TYR D 2 116 ? -27.155 -18.161 45.792  1    46.55  ? 286 TYR D CD2 1 
ATOM   7651 C  CE1 . TYR D 2 116 ? -25.045 -19.549 44.628  1    45.52  ? 286 TYR D CE1 1 
ATOM   7652 C  CE2 . TYR D 2 116 ? -27.405 -19.24  44.956  1    45.62  ? 286 TYR D CE2 1 
ATOM   7653 C  CZ  . TYR D 2 116 ? -26.357 -19.938 44.376  1    46.67  ? 286 TYR D CZ  1 
ATOM   7654 O  OH  . TYR D 2 116 ? -26.665 -20.974 43.53   1    46.36  ? 286 TYR D OH  1 
ATOM   7655 N  N   . THR D 2 117 ? -23.673 -14.878 48.895  1    55.78  ? 287 THR D N   1 
ATOM   7656 C  CA  . THR D 2 117 ? -23.451 -13.596 49.545  1    57.7   ? 287 THR D CA  1 
ATOM   7657 C  C   . THR D 2 117 ? -24.3   -12.53  48.871  1    58.38  ? 287 THR D C   1 
ATOM   7658 O  O   . THR D 2 117 ? -24.626 -12.651 47.689  1    61.52  ? 287 THR D O   1 
ATOM   7659 C  CB  . THR D 2 117 ? -21.988 -13.154 49.48   1    57.19  ? 287 THR D CB  1 
ATOM   7660 O  OG1 . THR D 2 117 ? -21.645 -13.021 48.101  1    58.91  ? 287 THR D OG1 1 
ATOM   7661 C  CG2 . THR D 2 117 ? -21.064 -14.126 50.18   1    56.33  ? 287 THR D CG2 1 
ATOM   7662 N  N   . LYS D 2 118 ? -24.538 -11.446 49.612  1    54.39  ? 288 LYS D N   1 
ATOM   7663 C  CA  . LYS D 2 118 ? -25.196 -10.278 49.081  1    52.2   ? 288 LYS D CA  1 
ATOM   7664 C  C   . LYS D 2 118 ? -24.491 -9.77   47.824  1    52.75  ? 288 LYS D C   1 
ATOM   7665 O  O   . LYS D 2 118 ? -25.151 -9.398  46.864  1    57.34  ? 288 LYS D O   1 
ATOM   7666 C  CB  . LYS D 2 118 ? -25.384 -9.237  50.182  1    52.95  ? 288 LYS D CB  1 
ATOM   7667 C  CG  . LYS D 2 118 ? -26.292 -8.072  49.79   1    53.95  ? 288 LYS D CG  1 
ATOM   7668 C  CD  . LYS D 2 118 ? -26.394 -7.15   50.998  1    61.78  ? 288 LYS D CD  1 
ATOM   7669 C  CE  . LYS D 2 118 ? -27.25  -5.934  50.879  1    63.58  ? 288 LYS D CE  1 
ATOM   7670 N  NZ  . LYS D 2 118 ? -27.135 -5.149  52.112  1    65.56  ? 288 LYS D NZ  1 
ATOM   7671 N  N   . LYS D 2 119 ? -23.163 -9.71   47.837  1    53.76  ? 289 LYS D N   1 
ATOM   7672 C  CA  . LYS D 2 119 ? -22.375 -9.221  46.716  1    52.64  ? 289 LYS D CA  1 
ATOM   7673 C  C   . LYS D 2 119 ? -22.645 -10.074 45.479  1    50.95  ? 289 LYS D C   1 
ATOM   7674 O  O   . LYS D 2 119 ? -22.753 -9.555  44.369  1    49.24  ? 289 LYS D O   1 
ATOM   7675 C  CB  . LYS D 2 119 ? -20.89  -9.327  47.08   1    64.51  ? 289 LYS D CB  1 
ATOM   7676 C  CG  . LYS D 2 119 ? -19.874 -9.003  45.979  1    70.12  ? 289 LYS D CG  1 
ATOM   7677 C  CD  . LYS D 2 119 ? -19.253 -7.607  46.076  1    75.87  ? 289 LYS D CD  1 
ATOM   7678 C  CE  . LYS D 2 119 ? -18.076 -7.524  47.009  1    74.59  ? 289 LYS D CE  1 
ATOM   7679 N  NZ  . LYS D 2 119 ? -16.921 -8.237  46.453  1    72.89  ? 289 LYS D NZ  1 
ATOM   7680 N  N   . GLN D 2 120 ? -22.741 -11.394 45.666  1    49.26  ? 290 GLN D N   1 
ATOM   7681 C  CA  . GLN D 2 120 ? -23.027 -12.279 44.548  1    48.17  ? 290 GLN D CA  1 
ATOM   7682 C  C   . GLN D 2 120 ? -24.382 -11.951 43.921  1    47.66  ? 290 GLN D C   1 
ATOM   7683 O  O   . GLN D 2 120 ? -24.488 -11.843 42.701  1    45.08  ? 290 GLN D O   1 
ATOM   7684 C  CB  . GLN D 2 120 ? -22.93  -13.741 44.96   1    49.06  ? 290 GLN D CB  1 
ATOM   7685 C  CG  . GLN D 2 120 ? -21.491 -14.222 45.148  1    50.23  ? 290 GLN D CG  1 
ATOM   7686 C  CD  . GLN D 2 120 ? -21.435 -15.665 45.597  1    55.05  ? 290 GLN D CD  1 
ATOM   7687 O  OE1 . GLN D 2 120 ? -21.99  -16.032 46.633  1    60     ? 290 GLN D OE1 1 
ATOM   7688 N  NE2 . GLN D 2 120 ? -20.84  -16.522 44.78   1    57.95  ? 290 GLN D NE2 1 
ATOM   7689 N  N   . VAL D 2 121 ? -25.413 -11.773 44.756  1    45.82  ? 291 VAL D N   1 
ATOM   7690 C  CA  . VAL D 2 121 ? -26.74  -11.447 44.255  1    43.57  ? 291 VAL D CA  1 
ATOM   7691 C  C   . VAL D 2 121 ? -26.716 -10.131 43.477  1    42.07  ? 291 VAL D C   1 
ATOM   7692 O  O   . VAL D 2 121 ? -27.282 -10.035 42.38   1    40.63  ? 291 VAL D O   1 
ATOM   7693 C  CB  . VAL D 2 121 ? -27.771 -11.403 45.395  1    46.26  ? 291 VAL D CB  1 
ATOM   7694 C  CG1 . VAL D 2 121 ? -29.106 -10.826 44.916  1    43.19  ? 291 VAL D CG1 1 
ATOM   7695 C  CG2 . VAL D 2 121 ? -27.927 -12.777 46.052  1    41.84  ? 291 VAL D CG2 1 
ATOM   7696 N  N   . LEU D 2 122 ? -26.025 -9.136  44.04   1    43.23  ? 292 LEU D N   1 
ATOM   7697 C  CA  . LEU D 2 122 ? -25.972 -7.792  43.479  1    44.03  ? 292 LEU D CA  1 
ATOM   7698 C  C   . LEU D 2 122 ? -25.238 -7.802  42.148  1    42.49  ? 292 LEU D C   1 
ATOM   7699 O  O   . LEU D 2 122 ? -25.692 -7.166  41.196  1    43.41  ? 292 LEU D O   1 
ATOM   7700 C  CB  . LEU D 2 122 ? -25.288 -6.864  44.468  1    44.75  ? 292 LEU D CB  1 
ATOM   7701 C  CG  . LEU D 2 122 ? -26.138 -6.508  45.686  1    50.26  ? 292 LEU D CG  1 
ATOM   7702 C  CD1 . LEU D 2 122 ? -25.288 -5.77   46.717  1    52.06  ? 292 LEU D CD1 1 
ATOM   7703 C  CD2 . LEU D 2 122 ? -27.316 -5.661  45.209  1    50.46  ? 292 LEU D CD2 1 
ATOM   7704 N  N   . ARG D 2 123 ? -24.15  -8.574  42.088  1    40.59  ? 293 ARG D N   1 
ATOM   7705 C  CA  . ARG D 2 123 ? -23.417 -8.714  40.84   1    43.38  ? 293 ARG D CA  1 
ATOM   7706 C  C   . ARG D 2 123 ? -24.237 -9.478  39.792  1    41.83  ? 293 ARG D C   1 
ATOM   7707 O  O   . ARG D 2 123 ? -24.216 -9.12   38.621  1    40.97  ? 293 ARG D O   1 
ATOM   7708 C  CB  . ARG D 2 123 ? -22.032 -9.294  41.103  1    47.8   ? 293 ARG D CB  1 
ATOM   7709 C  CG  . ARG D 2 123 ? -21.058 -8.207  41.549  1    55.22  ? 293 ARG D CG  1 
ATOM   7710 C  CD  . ARG D 2 123 ? -19.694 -8.799  41.855  1    68.54  ? 293 ARG D CD  1 
ATOM   7711 N  NE  . ARG D 2 123 ? -18.74  -7.718  42.113  1    94.05  ? 293 ARG D NE  1 
ATOM   7712 C  CZ  . ARG D 2 123 ? -17.624 -7.887  42.836  1    106    ? 293 ARG D CZ  1 
ATOM   7713 N  NH1 . ARG D 2 123 ? -17.172 -9.109  43.084  1    108.42 ? 293 ARG D NH1 1 
ATOM   7714 N  NH2 . ARG D 2 123 ? -16.943 -6.838  43.283  1    92.45  ? 293 ARG D NH2 1 
ATOM   7715 N  N   . MET D 2 124 ? -24.994 -10.5   40.22   1    41.02  ? 294 MET D N   1 
ATOM   7716 C  CA  . MET D 2 124 ? -25.766 -11.29  39.289  1    39.41  ? 294 MET D CA  1 
ATOM   7717 C  C   . MET D 2 124 ? -26.873 -10.416 38.722  1    38.58  ? 294 MET D C   1 
ATOM   7718 O  O   . MET D 2 124 ? -27.189 -10.536 37.546  1    38.42  ? 294 MET D O   1 
ATOM   7719 C  CB  . MET D 2 124 ? -26.368 -12.538 39.925  1    39.28  ? 294 MET D CB  1 
ATOM   7720 C  CG  . MET D 2 124 ? -27.156 -13.383 38.932  1    38.66  ? 294 MET D CG  1 
ATOM   7721 S  SD  . MET D 2 124 ? -26.179 -14.042 37.563  1    43.45  ? 294 MET D SD  1 
ATOM   7722 C  CE  . MET D 2 124 ? -25.346 -15.438 38.354  1    38.11  ? 294 MET D CE  1 
ATOM   7723 N  N   . GLU D 2 125 ? -27.4   -9.512  39.543  1    39.91  ? 295 GLU D N   1 
ATOM   7724 C  CA  . GLU D 2 125 ? -28.423 -8.568  39.11   1    41.54  ? 295 GLU D CA  1 
ATOM   7725 C  C   . GLU D 2 125 ? -27.901 -7.804  37.906  1    43.24  ? 295 GLU D C   1 
ATOM   7726 O  O   . GLU D 2 125 ? -28.592 -7.719  36.877  1    43.69  ? 295 GLU D O   1 
ATOM   7727 C  CB  . GLU D 2 125 ? -28.787 -7.562  40.2    1    43.23  ? 295 GLU D CB  1 
ATOM   7728 C  CG  . GLU D 2 125 ? -29.872 -6.575  39.78   1    40.81  ? 295 GLU D CG  1 
ATOM   7729 C  CD  . GLU D 2 125 ? -30.332 -5.595  40.84   1    44.67  ? 295 GLU D CD  1 
ATOM   7730 O  OE1 . GLU D 2 125 ? -29.513 -4.748  41.26   1    46.15  ? 295 GLU D OE1 1 
ATOM   7731 O  OE2 . GLU D 2 125 ? -31.531 -5.652  41.24   1    46.94  ? 295 GLU D OE2 1 
ATOM   7732 N  N   . HIS D 2 126 ? -26.664 -7.319  38.027  1    42.92  ? 296 HIS D N   1 
ATOM   7733 C  CA  . HIS D 2 126 ? -26.036 -6.571  36.944  1    45.7   ? 296 HIS D CA  1 
ATOM   7734 C  C   . HIS D 2 126 ? -25.833 -7.474  35.724  1    44.41  ? 296 HIS D C   1 
ATOM   7735 O  O   . HIS D 2 126 ? -26.147 -7.06   34.617  1    45.58  ? 296 HIS D O   1 
ATOM   7736 C  CB  . HIS D 2 126 ? -24.779 -5.769  37.357  1    47.34  ? 296 HIS D CB  1 
ATOM   7737 C  CG  . HIS D 2 126 ? -24.599 -4.513  36.529  1    59.35  ? 296 HIS D CG  1 
ATOM   7738 N  ND1 . HIS D 2 126 ? -23.723 -3.486  36.813  1    61.97  ? 296 HIS D ND1 1 
ATOM   7739 C  CD2 . HIS D 2 126 ? -25.209 -4.139  35.344  1    64.91  ? 296 HIS D CD2 1 
ATOM   7740 C  CE1 . HIS D 2 126 ? -23.806 -2.558  35.842  1    66.35  ? 296 HIS D CE1 1 
ATOM   7741 N  NE2 . HIS D 2 126 ? -24.707 -2.925  34.939  1    62.43  ? 296 HIS D NE2 1 
ATOM   7742 N  N   . LEU D 2 127 ? -25.322 -8.695  35.915  1    41.5   ? 297 LEU D N   1 
ATOM   7743 C  CA  . LEU D 2 127 ? -25.058 -9.548  34.765  1    40.25  ? 297 LEU D CA  1 
ATOM   7744 C  C   . LEU D 2 127 ? -26.362 -9.848  34.021  1    39.89  ? 297 LEU D C   1 
ATOM   7745 O  O   . LEU D 2 127 ? -26.402 -9.826  32.807  1    41.47  ? 297 LEU D O   1 
ATOM   7746 C  CB  . LEU D 2 127 ? -24.337 -10.824 35.191  1    37.19  ? 297 LEU D CB  1 
ATOM   7747 C  CG  . LEU D 2 127 ? -23.95  -11.769 34.04   1    39.57  ? 297 LEU D CG  1 
ATOM   7748 C  CD1 . LEU D 2 127 ? -23.002 -11.185 32.988  1    37.12  ? 297 LEU D CD1 1 
ATOM   7749 C  CD2 . LEU D 2 127 ? -23.343 -13.051 34.581  1    41.1   ? 297 LEU D CD2 1 
ATOM   7750 N  N   . VAL D 2 128 ? -27.444 -10.108 34.76   1    40.08  ? 298 VAL D N   1 
ATOM   7751 C  CA  . VAL D 2 128 ? -28.725 -10.388 34.137  1    39.34  ? 298 VAL D CA  1 
ATOM   7752 C  C   . VAL D 2 128 ? -29.22  -9.175  33.347  1    39.69  ? 298 VAL D C   1 
ATOM   7753 O  O   . VAL D 2 128 ? -29.681 -9.33   32.214  1    38.83  ? 298 VAL D O   1 
ATOM   7754 C  CB  . VAL D 2 128 ? -29.755 -10.908 35.149  1    37.01  ? 298 VAL D CB  1 
ATOM   7755 C  CG1 . VAL D 2 128 ? -31.149 -10.995 34.527  1    35.82  ? 298 VAL D CG1 1 
ATOM   7756 C  CG2 . VAL D 2 128 ? -29.314 -12.25  35.725  1    32.55  ? 298 VAL D CG2 1 
ATOM   7757 N  N   . LEU D 2 129 ? -29.061 -7.97   33.914  1    39.39  ? 299 LEU D N   1 
ATOM   7758 C  CA  . LEU D 2 129 ? -29.465 -6.769  33.199  1    39.17  ? 299 LEU D CA  1 
ATOM   7759 C  C   . LEU D 2 129 ? -28.727 -6.673  31.868  1    42.05  ? 299 LEU D C   1 
ATOM   7760 O  O   . LEU D 2 129 ? -29.334 -6.362  30.842  1    40.56  ? 299 LEU D O   1 
ATOM   7761 C  CB  . LEU D 2 129 ? -29.309 -5.516  34.047  1    39.69  ? 299 LEU D CB  1 
ATOM   7762 C  CG  . LEU D 2 129 ? -30.43  -5.249  35.066  1    42.39  ? 299 LEU D CG  1 
ATOM   7763 C  CD1 . LEU D 2 129 ? -30.02  -4.178  36.058  1    34.93  ? 299 LEU D CD1 1 
ATOM   7764 C  CD2 . LEU D 2 129 ? -31.766 -4.906  34.365  1    39.03  ? 299 LEU D CD2 1 
ATOM   7765 N  N   . LYS D 2 130 ? -27.433 -6.991  31.897  1    42.88  ? 300 LYS D N   1 
ATOM   7766 C  CA  . LYS D 2 130 ? -26.573 -6.844  30.733  1    51.03  ? 300 LYS D CA  1 
ATOM   7767 C  C   . LYS D 2 130 ? -26.952 -7.88   29.673  1    46.13  ? 300 LYS D C   1 
ATOM   7768 O  O   . LYS D 2 130 ? -27.025 -7.559  28.484  1    46.13  ? 300 LYS D O   1 
ATOM   7769 C  CB  . LYS D 2 130 ? -25.08  -6.883  31.094  1    59.52  ? 300 LYS D CB  1 
ATOM   7770 C  CG  . LYS D 2 130 ? -24.605 -5.811  32.088  1    70.78  ? 300 LYS D CG  1 
ATOM   7771 C  CD  . LYS D 2 130 ? -23.09  -5.561  32.101  1    87.99  ? 300 LYS D CD  1 
ATOM   7772 C  CE  . LYS D 2 130 ? -22.449 -5.714  33.466  1    90.07  ? 300 LYS D CE  1 
ATOM   7773 N  NZ  . LYS D 2 130 ? -21.012 -6.007  33.477  1    95.37  ? 300 LYS D NZ  1 
ATOM   7774 N  N   . VAL D 2 131 ? -27.211 -9.109  30.119  1    40.64  ? 301 VAL D N   1 
ATOM   7775 C  CA  . VAL D 2 131 ? -27.531 -10.194 29.211  1    41.26  ? 301 VAL D CA  1 
ATOM   7776 C  C   . VAL D 2 131 ? -28.883 -9.938  28.545  1    44.3   ? 301 VAL D C   1 
ATOM   7777 O  O   . VAL D 2 131 ? -29.042 -10.18  27.356  1    47.24  ? 301 VAL D O   1 
ATOM   7778 C  CB  . VAL D 2 131 ? -27.47  -11.561 29.914  1    40.69  ? 301 VAL D CB  1 
ATOM   7779 C  CG1 . VAL D 2 131 ? -28.186 -12.661 29.113  1    34.67  ? 301 VAL D CG1 1 
ATOM   7780 C  CG2 . VAL D 2 131 ? -26.022 -11.931 30.25   1    38.24  ? 301 VAL D CG2 1 
ATOM   7781 N  N   . LEU D 2 132 ? -29.859 -9.432  29.305  1    44.13  ? 302 LEU D N   1 
ATOM   7782 C  CA  . LEU D 2 132 ? -31.159 -9.102  28.745  1    43.19  ? 302 LEU D CA  1 
ATOM   7783 C  C   . LEU D 2 132 ? -31.156 -7.703  28.111  1    44.68  ? 302 LEU D C   1 
ATOM   7784 O  O   . LEU D 2 132 ? -32.177 -7.293  27.572  1    49.18  ? 302 LEU D O   1 
ATOM   7785 C  CB  . LEU D 2 132 ? -32.21  -9.216  29.856  1    42.78  ? 302 LEU D CB  1 
ATOM   7786 C  CG  . LEU D 2 132 ? -32.348 -10.591 30.527  1    43.46  ? 302 LEU D CG  1 
ATOM   7787 C  CD1 . LEU D 2 132 ? -33.307 -10.567 31.702  1    41.98  ? 302 LEU D CD1 1 
ATOM   7788 C  CD2 . LEU D 2 132 ? -32.851 -11.603 29.533  1    44.46  ? 302 LEU D CD2 1 
ATOM   7789 N  N   . ALA D 2 133 ? -30.04  -6.947  28.198  1    45.07  ? 303 ALA D N   1 
ATOM   7790 C  CA  . ALA D 2 133 ? -29.959 -5.576  27.696  1    43.74  ? 303 ALA D CA  1 
ATOM   7791 C  C   . ALA D 2 133 ? -31.093 -4.707  28.268  1    45.86  ? 303 ALA D C   1 
ATOM   7792 O  O   . ALA D 2 133 ? -31.633 -3.857  27.564  1    46.88  ? 303 ALA D O   1 
ATOM   7793 C  CB  . ALA D 2 133 ? -29.935 -5.554  26.165  1    37.17  ? 303 ALA D CB  1 
ATOM   7794 N  N   . PHE D 2 134 ? -31.469 -4.919  29.542  1    44.6   ? 304 PHE D N   1 
ATOM   7795 C  CA  . PHE D 2 134 ? -32.535 -4.169  30.207  1    47     ? 304 PHE D CA  1 
ATOM   7796 C  C   . PHE D 2 134 ? -33.895 -4.291  29.509  1    49.05  ? 304 PHE D C   1 
ATOM   7797 O  O   . PHE D 2 134 ? -34.755 -3.413  29.654  1    46.25  ? 304 PHE D O   1 
ATOM   7798 C  CB  . PHE D 2 134 ? -32.255 -2.673  30.289  1    47.27  ? 304 PHE D CB  1 
ATOM   7799 C  CG  . PHE D 2 134 ? -31.307 -2.243  31.395  1    51.17  ? 304 PHE D CG  1 
ATOM   7800 C  CD1 . PHE D 2 134 ? -29.925 -2.322  31.228  1    47.92  ? 304 PHE D CD1 1 
ATOM   7801 C  CD2 . PHE D 2 134 ? -31.825 -1.698  32.57   1    47.32  ? 304 PHE D CD2 1 
ATOM   7802 C  CE1 . PHE D 2 134 ? -29.079 -1.896  32.242  1    53.28  ? 304 PHE D CE1 1 
ATOM   7803 C  CE2 . PHE D 2 134 ? -30.976 -1.241  33.557  1    50.03  ? 304 PHE D CE2 1 
ATOM   7804 C  CZ  . PHE D 2 134 ? -29.605 -1.341  33.394  1    54.3   ? 304 PHE D CZ  1 
ATOM   7805 N  N   . ASP D 2 135 ? -34.101 -5.39   28.772  1    49.29  ? 305 ASP D N   1 
ATOM   7806 C  CA  . ASP D 2 135 ? -35.345 -5.576  28.046  1    56.93  ? 305 ASP D CA  1 
ATOM   7807 C  C   . ASP D 2 135 ? -36.276 -6.401  28.932  1    46.73  ? 305 ASP D C   1 
ATOM   7808 O  O   . ASP D 2 135 ? -36.397 -7.606  28.74   1    46.93  ? 305 ASP D O   1 
ATOM   7809 C  CB  . ASP D 2 135 ? -35.074 -6.037  26.614  1    66.71  ? 305 ASP D CB  1 
ATOM   7810 C  CG  . ASP D 2 135 ? -34.475 -4.989  25.685  1    85.41  ? 305 ASP D CG  1 
ATOM   7811 O  OD1 . ASP D 2 135 ? -34.49  -3.78   26.002  1    99.05  ? 305 ASP D OD1 1 
ATOM   7812 O  OD2 . ASP D 2 135 ? -34.004 -5.383  24.622  1    104    ? 305 ASP D OD2 1 
ATOM   7813 N  N   . LEU D 2 136 ? -36.898 -5.743  29.921  1    45.62  ? 306 LEU D N   1 
ATOM   7814 C  CA  . LEU D 2 136 ? -37.541 -6.423  31.04   1    43.18  ? 306 LEU D CA  1 
ATOM   7815 C  C   . LEU D 2 136 ? -39.067 -6.457  30.948  1    44.3   ? 306 LEU D C   1 
ATOM   7816 O  O   . LEU D 2 136 ? -39.696 -7.248  31.664  1    45.58  ? 306 LEU D O   1 
ATOM   7817 C  CB  . LEU D 2 136 ? -37.111 -5.796  32.37   1    45.2   ? 306 LEU D CB  1 
ATOM   7818 C  CG  . LEU D 2 136 ? -35.63  -5.885  32.778  1    46.47  ? 306 LEU D CG  1 
ATOM   7819 C  CD1 . LEU D 2 136 ? -35.542 -5.843  34.28   1    49.19  ? 306 LEU D CD1 1 
ATOM   7820 C  CD2 . LEU D 2 136 ? -34.881 -7.119  32.32   1    41.27  ? 306 LEU D CD2 1 
ATOM   7821 N  N   . ALA D 2 137 ? -39.677 -5.59   30.116  1    45.33  ? 307 ALA D N   1 
ATOM   7822 C  CA  . ALA D 2 137 ? -41.135 -5.535  30.04   1    44.96  ? 307 ALA D CA  1 
ATOM   7823 C  C   . ALA D 2 137 ? -41.647 -6.638  29.123  1    45.36  ? 307 ALA D C   1 
ATOM   7824 O  O   . ALA D 2 137 ? -42.258 -6.351  28.107  1    49.02  ? 307 ALA D O   1 
ATOM   7825 C  CB  . ALA D 2 137 ? -41.62  -4.175  29.593  1    43.01  ? 307 ALA D CB  1 
ATOM   7826 N  N   . ALA D 2 138 ? -41.418 -7.898  29.518  1    45.61  ? 308 ALA D N   1 
ATOM   7827 C  CA  . ALA D 2 138 ? -41.839 -9.072  28.768  1    45.57  ? 308 ALA D CA  1 
ATOM   7828 C  C   . ALA D 2 138 ? -43.335 -9.322  28.957  1    52.07  ? 308 ALA D C   1 
ATOM   7829 O  O   . ALA D 2 138 ? -43.845 -9.276  30.076  1    55.8   ? 308 ALA D O   1 
ATOM   7830 C  CB  . ALA D 2 138 ? -41.04  -10.284 29.188  1    38.13  ? 308 ALA D CB  1 
ATOM   7831 N  N   . PRO D 2 139 ? -44.092 -9.589  27.873  1    54.69  ? 309 PRO D N   1 
ATOM   7832 C  CA  . PRO D 2 139 ? -45.473 -10.047 28.02   1    56.09  ? 309 PRO D CA  1 
ATOM   7833 C  C   . PRO D 2 139 ? -45.483 -11.456 28.616  1    56.84  ? 309 PRO D C   1 
ATOM   7834 O  O   . PRO D 2 139 ? -44.692 -12.309 28.19   1    53.95  ? 309 PRO D O   1 
ATOM   7835 C  CB  . PRO D 2 139 ? -46.025 -10.016 26.565  1    55.84  ? 309 PRO D CB  1 
ATOM   7836 C  CG  . PRO D 2 139 ? -45.01  -9.235  25.747  1    53.89  ? 309 PRO D CG  1 
ATOM   7837 C  CD  . PRO D 2 139 ? -43.671 -9.436  26.463  1    55.85  ? 309 PRO D CD  1 
ATOM   7838 N  N   . THR D 2 140 ? -46.407 -11.681 29.574  1    51.58  ? 310 THR D N   1 
ATOM   7839 C  CA  . THR D 2 140 ? -46.546 -12.937 30.303  1    49.97  ? 310 THR D CA  1 
ATOM   7840 C  C   . THR D 2 140 ? -47.853 -13.626 29.936  1    51.19  ? 310 THR D C   1 
ATOM   7841 O  O   . THR D 2 140 ? -48.73  -13.002 29.362  1    51.59  ? 310 THR D O   1 
ATOM   7842 C  CB  . THR D 2 140 ? -46.535 -12.664 31.811  1    51.69  ? 310 THR D CB  1 
ATOM   7843 O  OG1 . THR D 2 140 ? -47.613 -11.781 32.124  1    48.81  ? 310 THR D OG1 1 
ATOM   7844 C  CG2 . THR D 2 140 ? -45.225 -12.068 32.305  1    45.96  ? 310 THR D CG2 1 
ATOM   7845 N  N   . ILE D 2 141 ? -48.007 -14.887 30.348  1    53.69  ? 311 ILE D N   1 
ATOM   7846 C  CA  . ILE D 2 141 ? -49.267 -15.618 30.253  1    57.5   ? 311 ILE D CA  1 
ATOM   7847 C  C   . ILE D 2 141 ? -50.38  -14.828 30.93   1    61.73  ? 311 ILE D C   1 
ATOM   7848 O  O   . ILE D 2 141 ? -51.49  -14.715 30.397  1    66.43  ? 311 ILE D O   1 
ATOM   7849 C  CB  . ILE D 2 141 ? -49.131 -17.007 30.904  1    56.42  ? 311 ILE D CB  1 
ATOM   7850 C  CG1 . ILE D 2 141 ? -48.264 -17.928 30.06   1    59.86  ? 311 ILE D CG1 1 
ATOM   7851 C  CG2 . ILE D 2 141 ? -50.496 -17.63  31.182  1    54.94  ? 311 ILE D CG2 1 
ATOM   7852 C  CD1 . ILE D 2 141 ? -47.651 -19.066 30.855  1    60.99  ? 311 ILE D CD1 1 
ATOM   7853 N  N   . ASN D 2 142 ? -50.068 -14.346 32.141  1    60.34  ? 312 ASN D N   1 
ATOM   7854 C  CA  . ASN D 2 142 ? -50.957 -13.603 33.017  1    60.34  ? 312 ASN D CA  1 
ATOM   7855 C  C   . ASN D 2 142 ? -51.493 -12.357 32.289  1    57.53  ? 312 ASN D C   1 
ATOM   7856 O  O   . ASN D 2 142 ? -52.655 -11.999 32.466  1    61.17  ? 312 ASN D O   1 
ATOM   7857 C  CB  . ASN D 2 142 ? -50.158 -13.29  34.281  1    67.93  ? 312 ASN D CB  1 
ATOM   7858 C  CG  . ASN D 2 142 ? -50.894 -13.439 35.592  1    73.13  ? 312 ASN D CG  1 
ATOM   7859 O  OD1 . ASN D 2 142 ? -51.581 -12.507 36.035  1    76.96  ? 312 ASN D OD1 1 
ATOM   7860 N  ND2 . ASN D 2 142 ? -50.672 -14.554 36.278  1    78.55  ? 312 ASN D ND2 1 
ATOM   7861 N  N   . GLN D 2 143 ? -50.645 -11.656 31.515  1    54.45  ? 313 GLN D N   1 
ATOM   7862 C  CA  . GLN D 2 143 ? -51.014 -10.409 30.84   1    59.18  ? 313 GLN D CA  1 
ATOM   7863 C  C   . GLN D 2 143 ? -52.054 -10.65  29.745  1    60.62  ? 313 GLN D C   1 
ATOM   7864 O  O   . GLN D 2 143 ? -52.818 -9.744  29.425  1    68.24  ? 313 GLN D O   1 
ATOM   7865 C  CB  . GLN D 2 143 ? -49.853 -9.667  30.165  1    55.43  ? 313 GLN D CB  1 
ATOM   7866 C  CG  . GLN D 2 143 ? -48.978 -8.864  31.118  1    55.38  ? 313 GLN D CG  1 
ATOM   7867 C  CD  . GLN D 2 143 ? -47.756 -8.263  30.467  1    57.42  ? 313 GLN D CD  1 
ATOM   7868 O  OE1 . GLN D 2 143 ? -47.851 -7.36   29.623  1    64.42  ? 313 GLN D OE1 1 
ATOM   7869 N  NE2 . GLN D 2 143 ? -46.587 -8.754  30.868  1    52.9   ? 313 GLN D NE2 1 
ATOM   7870 N  N   . PHE D 2 144 ? -52.019 -11.846 29.147  1    56.16  ? 314 PHE D N   1 
ATOM   7871 C  CA  . PHE D 2 144 ? -53.011 -12.271 28.179  1    59.56  ? 314 PHE D CA  1 
ATOM   7872 C  C   . PHE D 2 144 ? -54.288 -12.756 28.876  1    62.4   ? 314 PHE D C   1 
ATOM   7873 O  O   . PHE D 2 144 ? -55.383 -12.349 28.48   1    62.08  ? 314 PHE D O   1 
ATOM   7874 C  CB  . PHE D 2 144 ? -52.438 -13.329 27.242  1    60.46  ? 314 PHE D CB  1 
ATOM   7875 C  CG  . PHE D 2 144 ? -51.438 -12.751 26.267  1    58.41  ? 314 PHE D CG  1 
ATOM   7876 C  CD1 . PHE D 2 144 ? -51.874 -11.982 25.197  1    62.1   ? 314 PHE D CD1 1 
ATOM   7877 C  CD2 . PHE D 2 144 ? -50.082 -12.984 26.429  1    55.55  ? 314 PHE D CD2 1 
ATOM   7878 C  CE1 . PHE D 2 144 ? -50.961 -11.446 24.299  1    63.53  ? 314 PHE D CE1 1 
ATOM   7879 C  CE2 . PHE D 2 144 ? -49.173 -12.44  25.537  1    58.07  ? 314 PHE D CE2 1 
ATOM   7880 C  CZ  . PHE D 2 144 ? -49.611 -11.671 24.476  1    62.32  ? 314 PHE D CZ  1 
ATOM   7881 N  N   . LEU D 2 145 ? -54.137 -13.593 29.915  1    62.24  ? 315 LEU D N   1 
ATOM   7882 C  CA  . LEU D 2 145 ? -55.247 -14.087 30.722  1    64.39  ? 315 LEU D CA  1 
ATOM   7883 C  C   . LEU D 2 145 ? -56.142 -12.944 31.218  1    69.2   ? 315 LEU D C   1 
ATOM   7884 O  O   . LEU D 2 145 ? -57.369 -13.078 31.172  1    76.44  ? 315 LEU D O   1 
ATOM   7885 C  CB  . LEU D 2 145 ? -54.749 -14.919 31.906  1    61.09  ? 315 LEU D CB  1 
ATOM   7886 C  CG  . LEU D 2 145 ? -54.265 -16.333 31.594  1    58.66  ? 315 LEU D CG  1 
ATOM   7887 C  CD1 . LEU D 2 145 ? -53.777 -16.988 32.881  1    57.42  ? 315 LEU D CD1 1 
ATOM   7888 C  CD2 . LEU D 2 145 ? -55.371 -17.127 30.932  1    59.17  ? 315 LEU D CD2 1 
ATOM   7889 N  N   . THR D 2 146 ? -55.546 -11.854 31.737  1    62.89  ? 316 THR D N   1 
ATOM   7890 C  CA  . THR D 2 146 ? -56.348 -10.824 32.387  1    63.15  ? 316 THR D CA  1 
ATOM   7891 C  C   . THR D 2 146 ? -57.243 -10.157 31.343  1    65.81  ? 316 THR D C   1 
ATOM   7892 O  O   . THR D 2 146 ? -58.363 -9.741  31.672  1    66.57  ? 316 THR D O   1 
ATOM   7893 C  CB  . THR D 2 146 ? -55.543 -9.821  33.225  1    61.07  ? 316 THR D CB  1 
ATOM   7894 O  OG1 . THR D 2 146 ? -54.601 -9.158  32.395  1    61.84  ? 316 THR D OG1 1 
ATOM   7895 C  CG2 . THR D 2 146 ? -54.775 -10.445 34.375  1    59.46  ? 316 THR D CG2 1 
ATOM   7896 N  N   . GLN D 2 147 ? -56.739 -10.078 30.093  1    66.32  ? 317 GLN D N   1 
ATOM   7897 C  CA  . GLN D 2 147 ? -57.47  -9.542  28.946  1    69.16  ? 317 GLN D CA  1 
ATOM   7898 C  C   . GLN D 2 147 ? -58.568 -10.51  28.495  1    71.92  ? 317 GLN D C   1 
ATOM   7899 O  O   . GLN D 2 147 ? -59.659 -10.098 28.079  1    73.34  ? 317 GLN D O   1 
ATOM   7900 C  CB  . GLN D 2 147 ? -56.54  -9.293  27.757  1    66.42  ? 317 GLN D CB  1 
ATOM   7901 C  CG  . GLN D 2 147 ? -55.699 -8.03   27.872  1    67.39  ? 317 GLN D CG  1 
ATOM   7902 C  CD  . GLN D 2 147 ? -54.869 -7.781  26.637  1    69.48  ? 317 GLN D CD  1 
ATOM   7903 O  OE1 . GLN D 2 147 ? -55.349 -7.806  25.495  1    72.43  ? 317 GLN D OE1 1 
ATOM   7904 N  NE2 . GLN D 2 147 ? -53.587 -7.575  26.868  1    74.88  ? 317 GLN D NE2 1 
ATOM   7905 N  N   . TYR D 2 148 ? -58.231 -11.806 28.509  1    71.93  ? 318 TYR D N   1 
ATOM   7906 C  CA  . TYR D 2 148 ? -59.132 -12.843 28.04   1    73.11  ? 318 TYR D CA  1 
ATOM   7907 C  C   . TYR D 2 148 ? -60.302 -12.952 29.018  1    75.9   ? 318 TYR D C   1 
ATOM   7908 O  O   . TYR D 2 148 ? -61.424 -13.241 28.592  1    79.74  ? 318 TYR D O   1 
ATOM   7909 C  CB  . TYR D 2 148 ? -58.425 -14.191 27.882  1    70.11  ? 318 TYR D CB  1 
ATOM   7910 C  CG  . TYR D 2 148 ? -57.33  -14.375 26.842  1    66.12  ? 318 TYR D CG  1 
ATOM   7911 C  CD1 . TYR D 2 148 ? -57.148 -13.499 25.77   1    65.58  ? 318 TYR D CD1 1 
ATOM   7912 C  CD2 . TYR D 2 148 ? -56.475 -15.476 26.944  1    64.38  ? 318 TYR D CD2 1 
ATOM   7913 C  CE1 . TYR D 2 148 ? -56.134 -13.727 24.845  1    64.83  ? 318 TYR D CE1 1 
ATOM   7914 C  CE2 . TYR D 2 148 ? -55.467 -15.708 26.023  1    62.27  ? 318 TYR D CE2 1 
ATOM   7915 C  CZ  . TYR D 2 148 ? -55.29  -14.829 24.975  1    63.65  ? 318 TYR D CZ  1 
ATOM   7916 O  OH  . TYR D 2 148 ? -54.256 -15.104 24.118  1    66.26  ? 318 TYR D OH  1 
ATOM   7917 N  N   . PHE D 2 149 ? -60.031 -12.714 30.313  1    72.54  ? 319 PHE D N   1 
ATOM   7918 C  CA  . PHE D 2 149 ? -61.039 -12.756 31.357  1    75.63  ? 319 PHE D CA  1 
ATOM   7919 C  C   . PHE D 2 149 ? -62.153 -11.746 31.098  1    83.54  ? 319 PHE D C   1 
ATOM   7920 O  O   . PHE D 2 149 ? -63.282 -11.959 31.563  1    88.96  ? 319 PHE D O   1 
ATOM   7921 C  CB  . PHE D 2 149 ? -60.443 -12.509 32.736  1    74.26  ? 319 PHE D CB  1 
ATOM   7922 C  CG  . PHE D 2 149 ? -59.576 -13.629 33.278  1    77.18  ? 319 PHE D CG  1 
ATOM   7923 C  CD1 . PHE D 2 149 ? -59.557 -14.888 32.674  1    79.23  ? 319 PHE D CD1 1 
ATOM   7924 C  CD2 . PHE D 2 149 ? -58.794 -13.42  34.411  1    78.75  ? 319 PHE D CD2 1 
ATOM   7925 C  CE1 . PHE D 2 149 ? -58.774 -15.915 33.194  1    80.66  ? 319 PHE D CE1 1 
ATOM   7926 C  CE2 . PHE D 2 149 ? -58.002 -14.447 34.915  1    81.05  ? 319 PHE D CE2 1 
ATOM   7927 C  CZ  . PHE D 2 149 ? -57.989 -15.694 34.307  1    79.36  ? 319 PHE D CZ  1 
ATOM   7928 N  N   . LEU D 2 150 ? -61.839 -10.675 30.346  1    82.43  ? 320 LEU D N   1 
ATOM   7929 C  CA  . LEU D 2 150 ? -62.825 -9.651  30.02   1    84.73  ? 320 LEU D CA  1 
ATOM   7930 C  C   . LEU D 2 150 ? -63.894 -10.166 29.053  1    90.99  ? 320 LEU D C   1 
ATOM   7931 O  O   . LEU D 2 150 ? -64.949 -9.551  28.932  1    97.52  ? 320 LEU D O   1 
ATOM   7932 C  CB  . LEU D 2 150 ? -62.158 -8.402  29.447  1    78.59  ? 320 LEU D CB  1 
ATOM   7933 C  CG  . LEU D 2 150 ? -61.141 -7.676  30.326  1    76.8   ? 320 LEU D CG  1 
ATOM   7934 C  CD1 . LEU D 2 150 ? -60.866 -6.317  29.659  1    74.57  ? 320 LEU D CD1 1 
ATOM   7935 C  CD2 . LEU D 2 150 ? -61.607 -7.525  31.772  1    79.78  ? 320 LEU D CD2 1 
ATOM   7936 N  N   . HIS D 2 151 ? -63.613 -11.254 28.328  1    93.74  ? 321 HIS D N   1 
ATOM   7937 C  CA  . HIS D 2 151 ? -64.575 -11.807 27.388  1    98.68  ? 321 HIS D CA  1 
ATOM   7938 C  C   . HIS D 2 151 ? -65.35  -12.944 28.045  1    100.04 ? 321 HIS D C   1 
ATOM   7939 O  O   . HIS D 2 151 ? -65.757 -13.881 27.37   1    105.67 ? 321 HIS D O   1 
ATOM   7940 C  CB  . HIS D 2 151 ? -63.894 -12.301 26.106  1    102.37 ? 321 HIS D CB  1 
ATOM   7941 C  CG  . HIS D 2 151 ? -63.297 -11.242 25.232  1    110.3  ? 321 HIS D CG  1 
ATOM   7942 N  ND1 . HIS D 2 151 ? -63.493 -11.228 23.863  1    114.23 ? 321 HIS D ND1 1 
ATOM   7943 C  CD2 . HIS D 2 151 ? -62.513 -10.184 25.515  1    105.81 ? 321 HIS D CD2 1 
ATOM   7944 C  CE1 . HIS D 2 151 ? -62.843 -10.193 23.339  1    110.45 ? 321 HIS D CE1 1 
ATOM   7945 N  NE2 . HIS D 2 151 ? -62.25  -9.542  24.327  1    108.18 ? 321 HIS D NE2 1 
ATOM   7946 N  N   . GLN D 2 152 ? -65.542 -12.862 29.364  1    99.7   ? 322 GLN D N   1 
ATOM   7947 C  CA  . GLN D 2 152 ? -66.386 -13.815 30.064  1    104.1  ? 322 GLN D CA  1 
ATOM   7948 C  C   . GLN D 2 152 ? -67.831 -13.315 30.044  1    112.59 ? 322 GLN D C   1 
ATOM   7949 O  O   . GLN D 2 152 ? -68.09  -12.171 29.674  1    109.44 ? 322 GLN D O   1 
ATOM   7950 C  CB  . GLN D 2 152 ? -65.901 -13.976 31.5    1    98.89  ? 322 GLN D CB  1 
ATOM   7951 C  CG  . GLN D 2 152 ? -64.957 -15.145 31.75   1    100.24 ? 322 GLN D CG  1 
ATOM   7952 C  CD  . GLN D 2 152 ? -64.382 -15.127 33.155  1    102.92 ? 322 GLN D CD  1 
ATOM   7953 O  OE1 . GLN D 2 152 ? -64.572 -16.067 33.932  1    107.83 ? 322 GLN D OE1 1 
ATOM   7954 N  NE2 . GLN D 2 152 ? -63.691 -14.049 33.517  1    93.99  ? 322 GLN D NE2 1 
ATOM   7955 N  N   . GLN D 2 153 ? -68.769 -14.201 30.414  1    123.48 ? 323 GLN D N   1 
ATOM   7956 C  CA  . GLN D 2 153 ? -70.163 -13.835 30.631  1    130.19 ? 323 GLN D CA  1 
ATOM   7957 C  C   . GLN D 2 153 ? -70.885 -14.958 31.377  1    130.63 ? 323 GLN D C   1 
ATOM   7958 O  O   . GLN D 2 153 ? -71.217 -15.976 30.774  1    128.08 ? 323 GLN D O   1 
ATOM   7959 C  CB  . GLN D 2 153 ? -70.959 -13.511 29.365  1    137.51 ? 323 GLN D CB  1 
ATOM   7960 C  CG  . GLN D 2 153 ? -72.372 -13.019 29.666  1    147.27 ? 323 GLN D CG  1 
ATOM   7961 C  CD  . GLN D 2 153 ? -72.388 -11.705 30.42   1    155.12 ? 323 GLN D CD  1 
ATOM   7962 O  OE1 . GLN D 2 153 ? -71.876 -10.679 29.945  1    140.4  ? 323 GLN D OE1 1 
ATOM   7963 N  NE2 . GLN D 2 153 ? -72.955 -11.725 31.621  1    164.15 ? 323 GLN D NE2 1 
ATOM   7964 N  N   . PRO D 2 154 ? -71.131 -14.814 32.703  1    134.18 ? 324 PRO D N   1 
ATOM   7965 C  CA  . PRO D 2 154 ? -70.562 -13.708 33.483  1    130.13 ? 324 PRO D CA  1 
ATOM   7966 C  C   . PRO D 2 154 ? -69.086 -14.008 33.736  1    125.66 ? 324 PRO D C   1 
ATOM   7967 O  O   . PRO D 2 154 ? -68.514 -14.861 33.061  1    126.71 ? 324 PRO D O   1 
ATOM   7968 C  CB  . PRO D 2 154 ? -71.41  -13.727 34.768  1    129.22 ? 324 PRO D CB  1 
ATOM   7969 C  CG  . PRO D 2 154 ? -71.791 -15.186 34.932  1    135.59 ? 324 PRO D CG  1 
ATOM   7970 C  CD  . PRO D 2 154 ? -71.978 -15.71  33.515  1    137.67 ? 324 PRO D CD  1 
ATOM   7971 N  N   . ALA D 2 155 ? -68.462 -13.315 34.701  1    114.89 ? 325 ALA D N   1 
ATOM   7972 C  CA  . ALA D 2 155 ? -67.104 -13.648 35.094  1    102.25 ? 325 ALA D CA  1 
ATOM   7973 C  C   . ALA D 2 155 ? -67.134 -14.644 36.259  1    105.77 ? 325 ALA D C   1 
ATOM   7974 O  O   . ALA D 2 155 ? -67.761 -14.386 37.283  1    114.9  ? 325 ALA D O   1 
ATOM   7975 C  CB  . ALA D 2 155 ? -66.374 -12.376 35.427  1    93.48  ? 325 ALA D CB  1 
ATOM   7976 N  N   . ASN D 2 156 ? -66.518 -15.82  36.077  1    102.38 ? 326 ASN D N   1 
ATOM   7977 C  CA  . ASN D 2 156 ? -66.429 -16.823 37.13   1    101.37 ? 326 ASN D CA  1 
ATOM   7978 C  C   . ASN D 2 156 ? -65.044 -16.709 37.771  1    95.19  ? 326 ASN D C   1 
ATOM   7979 O  O   . ASN D 2 156 ? -64.032 -16.698 37.073  1    88.87  ? 326 ASN D O   1 
ATOM   7980 C  CB  . ASN D 2 156 ? -66.745 -18.233 36.619  1    104.51 ? 326 ASN D CB  1 
ATOM   7981 C  CG  . ASN D 2 156 ? -66.927 -19.242 37.725  1    109.77 ? 326 ASN D CG  1 
ATOM   7982 O  OD1 . ASN D 2 156 ? -66.164 -19.258 38.692  1    114.9  ? 326 ASN D OD1 1 
ATOM   7983 N  ND2 . ASN D 2 156 ? -67.931 -20.092 37.612  1    119.45 ? 326 ASN D ND2 1 
ATOM   7984 N  N   . CYS D 2 157 ? -65.016 -16.627 39.105  1    94.35  ? 327 CYS D N   1 
ATOM   7985 C  CA  . CYS D 2 157 ? -63.774 -16.449 39.84   1    93.79  ? 327 CYS D CA  1 
ATOM   7986 C  C   . CYS D 2 157 ? -63.043 -17.787 39.994  1    91.71  ? 327 CYS D C   1 
ATOM   7987 O  O   . CYS D 2 157 ? -61.833 -17.813 40.203  1    86.13  ? 327 CYS D O   1 
ATOM   7988 C  CB  . CYS D 2 157 ? -64.015 -15.784 41.194  1    96.99  ? 327 CYS D CB  1 
ATOM   7989 S  SG  . CYS D 2 157 ? -64.774 -16.88  42.427  1    110.7  ? 327 CYS D SG  1 
ATOM   7990 N  N   . LYS D 2 158 ? -63.793 -18.897 39.901  1    95.45  ? 328 LYS D N   1 
ATOM   7991 C  CA  . LYS D 2 158 ? -63.198 -20.231 39.903  1    95.87  ? 328 LYS D CA  1 
ATOM   7992 C  C   . LYS D 2 158 ? -62.503 -20.482 38.557  1    93.52  ? 328 LYS D C   1 
ATOM   7993 O  O   . LYS D 2 158 ? -61.4   -21.038 38.521  1    84.78  ? 328 LYS D O   1 
ATOM   7994 C  CB  . LYS D 2 158 ? -64.21  -21.324 40.279  1    95.51  ? 328 LYS D CB  1 
ATOM   7995 C  CG  . LYS D 2 158 ? -64.614 -21.339 41.75   1    98.99  ? 328 LYS D CG  1 
ATOM   7996 C  CD  . LYS D 2 158 ? -66.087 -21.653 42.015  1    102.94 ? 328 LYS D CD  1 
ATOM   7997 C  CE  . LYS D 2 158 ? -66.52  -23.065 41.835  1    109.02 ? 328 LYS D CE  1 
ATOM   7998 N  NZ  . LYS D 2 158 ? -66.523 -23.756 43.126  1    112.25 ? 328 LYS D NZ  1 
ATOM   7999 N  N   . VAL D 2 159 ? -63.163 -20.076 37.456  1    90.94  ? 329 VAL D N   1 
ATOM   8000 C  CA  . VAL D 2 159 ? -62.546 -20.126 36.141  1    87.28  ? 329 VAL D CA  1 
ATOM   8001 C  C   . VAL D 2 159 ? -61.219 -19.362 36.189  1    83.31  ? 329 VAL D C   1 
ATOM   8002 O  O   . VAL D 2 159 ? -60.163 -19.926 35.905  1    82.49  ? 329 VAL D O   1 
ATOM   8003 C  CB  . VAL D 2 159 ? -63.487 -19.626 35.03   1    87.61  ? 329 VAL D CB  1 
ATOM   8004 C  CG1 . VAL D 2 159 ? -62.749 -19.319 33.735  1    84.67  ? 329 VAL D CG1 1 
ATOM   8005 C  CG2 . VAL D 2 159 ? -64.606 -20.62  34.763  1    94.19  ? 329 VAL D CG2 1 
ATOM   8006 N  N   . GLU D 2 160 ? -61.274 -18.093 36.603  1    81.68  ? 330 GLU D N   1 
ATOM   8007 C  CA  . GLU D 2 160 ? -60.092 -17.246 36.655  1    83.58  ? 330 GLU D CA  1 
ATOM   8008 C  C   . GLU D 2 160 ? -58.989 -17.945 37.447  1    79.67  ? 330 GLU D C   1 
ATOM   8009 O  O   . GLU D 2 160 ? -57.927 -18.222 36.9    1    77.62  ? 330 GLU D O   1 
ATOM   8010 C  CB  . GLU D 2 160 ? -60.438 -15.842 37.15   1    84.33  ? 330 GLU D CB  1 
ATOM   8011 C  CG  . GLU D 2 160 ? -61.321 -15.087 36.159  1    90.06  ? 330 GLU D CG  1 
ATOM   8012 C  CD  . GLU D 2 160 ? -61.715 -13.665 36.515  1    93.2   ? 330 GLU D CD  1 
ATOM   8013 O  OE1 . GLU D 2 160 ? -61.441 -13.22  37.644  1    92.52  ? 330 GLU D OE1 1 
ATOM   8014 O  OE2 . GLU D 2 160 ? -62.303 -13.008 35.634  1    97.82  ? 330 GLU D OE2 1 
ATOM   8015 N  N   . SER D 2 161 ? -59.279 -18.287 38.707  1    79.95  ? 331 SER D N   1 
ATOM   8016 C  CA  . SER D 2 161 ? -58.317 -18.928 39.594  1    78.78  ? 331 SER D CA  1 
ATOM   8017 C  C   . SER D 2 161 ? -57.759 -20.222 38.997  1    80.38  ? 331 SER D C   1 
ATOM   8018 O  O   . SER D 2 161 ? -56.588 -20.525 39.212  1    81.73  ? 331 SER D O   1 
ATOM   8019 C  CB  . SER D 2 161 ? -58.887 -19.15  40.978  1    79.65  ? 331 SER D CB  1 
ATOM   8020 O  OG  . SER D 2 161 ? -59.199 -17.917 41.615  1    80.14  ? 331 SER D OG  1 
ATOM   8021 N  N   . LEU D 2 162 ? -58.589 -20.978 38.259  1    80.99  ? 332 LEU D N   1 
ATOM   8022 C  CA  . LEU D 2 162 ? -58.152 -22.223 37.645  1    78.59  ? 332 LEU D CA  1 
ATOM   8023 C  C   . LEU D 2 162 ? -57.241 -21.949 36.442  1    76.01  ? 332 LEU D C   1 
ATOM   8024 O  O   . LEU D 2 162 ? -56.261 -22.664 36.23   1    73.91  ? 332 LEU D O   1 
ATOM   8025 C  CB  . LEU D 2 162 ? -59.34  -23.108 37.273  1    81.32  ? 332 LEU D CB  1 
ATOM   8026 C  CG  . LEU D 2 162 ? -58.996 -24.489 36.697  1    85.21  ? 332 LEU D CG  1 
ATOM   8027 C  CD1 . LEU D 2 162 ? -58.115 -25.286 37.655  1    88.23  ? 332 LEU D CD1 1 
ATOM   8028 C  CD2 . LEU D 2 162 ? -60.224 -25.323 36.345  1    87.86  ? 332 LEU D CD2 1 
ATOM   8029 N  N   . ALA D 2 163 ? -57.576 -20.941 35.626  1    72.96  ? 333 ALA D N   1 
ATOM   8030 C  CA  . ALA D 2 163 ? -56.731 -20.605 34.494  1    70.33  ? 333 ALA D CA  1 
ATOM   8031 C  C   . ALA D 2 163 ? -55.353 -20.141 34.989  1    71.06  ? 333 ALA D C   1 
ATOM   8032 O  O   . ALA D 2 163 ? -54.319 -20.647 34.534  1    68.94  ? 333 ALA D O   1 
ATOM   8033 C  CB  . ALA D 2 163 ? -57.429 -19.591 33.618  1    71.7   ? 333 ALA D CB  1 
ATOM   8034 N  N   . MET D 2 164 ? -55.34  -19.223 35.97   1    68.85  ? 334 MET D N   1 
ATOM   8035 C  CA  . MET D 2 164 ? -54.101 -18.767 36.593  1    69.14  ? 334 MET D CA  1 
ATOM   8036 C  C   . MET D 2 164 ? -53.237 -19.961 37.007  1    68.52  ? 334 MET D C   1 
ATOM   8037 O  O   . MET D 2 164 ? -52.027 -19.959 36.764  1    69.12  ? 334 MET D O   1 
ATOM   8038 C  CB  . MET D 2 164 ? -54.356 -17.902 37.838  1    69.28  ? 334 MET D CB  1 
ATOM   8039 C  CG  . MET D 2 164 ? -54.826 -16.493 37.553  1    73.47  ? 334 MET D CG  1 
ATOM   8040 S  SD  . MET D 2 164 ? -53.599 -15.572 36.606  1    84.25  ? 334 MET D SD  1 
ATOM   8041 C  CE  . MET D 2 164 ? -54.557 -14.181 35.993  1    83.88  ? 334 MET D CE  1 
ATOM   8042 N  N   . PHE D 2 165 ? -53.882 -20.966 37.623  1    67.98  ? 335 PHE D N   1 
ATOM   8043 C  CA  . PHE D 2 165 ? -53.238 -22.155 38.153  1    64.01  ? 335 PHE D CA  1 
ATOM   8044 C  C   . PHE D 2 165 ? -52.603 -22.985 37.048  1    63.94  ? 335 PHE D C   1 
ATOM   8045 O  O   . PHE D 2 165 ? -51.483 -23.458 37.221  1    69     ? 335 PHE D O   1 
ATOM   8046 C  CB  . PHE D 2 165 ? -54.261 -23.006 38.898  1    64.77  ? 335 PHE D CB  1 
ATOM   8047 C  CG  . PHE D 2 165 ? -53.838 -24.446 39.136  1    65.91  ? 335 PHE D CG  1 
ATOM   8048 C  CD1 . PHE D 2 165 ? -52.875 -24.758 40.099  1    65.04  ? 335 PHE D CD1 1 
ATOM   8049 C  CD2 . PHE D 2 165 ? -54.427 -25.484 38.416  1    66.93  ? 335 PHE D CD2 1 
ATOM   8050 C  CE1 . PHE D 2 165 ? -52.503 -26.073 40.336  1    66.72  ? 335 PHE D CE1 1 
ATOM   8051 C  CE2 . PHE D 2 165 ? -54.062 -26.806 38.659  1    69.43  ? 335 PHE D CE2 1 
ATOM   8052 C  CZ  . PHE D 2 165 ? -53.099 -27.104 39.613  1    69.23  ? 335 PHE D CZ  1 
ATOM   8053 N  N   . LEU D 2 166 ? -53.324 -23.195 35.941  1    63.32  ? 336 LEU D N   1 
ATOM   8054 C  CA  . LEU D 2 166 ? -52.819 -24.002 34.836  1    62.57  ? 336 LEU D CA  1 
ATOM   8055 C  C   . LEU D 2 166 ? -51.634 -23.279 34.195  1    62.62  ? 336 LEU D C   1 
ATOM   8056 O  O   . LEU D 2 166 ? -50.597 -23.886 33.91   1    63.74  ? 336 LEU D O   1 
ATOM   8057 C  CB  . LEU D 2 166 ? -53.929 -24.249 33.81   1    63.01  ? 336 LEU D CB  1 
ATOM   8058 C  CG  . LEU D 2 166 ? -55.137 -25.082 34.258  1    64.23  ? 336 LEU D CG  1 
ATOM   8059 C  CD1 . LEU D 2 166 ? -56.215 -25.011 33.194  1    65.72  ? 336 LEU D CD1 1 
ATOM   8060 C  CD2 . LEU D 2 166 ? -54.821 -26.529 34.55   1    63.94  ? 336 LEU D CD2 1 
ATOM   8061 N  N   . GLY D 2 167 ? -51.814 -21.968 33.95   1    60.57  ? 337 GLY D N   1 
ATOM   8062 C  CA  . GLY D 2 167 ? -50.767 -21.129 33.403  1    58.25  ? 337 GLY D CA  1 
ATOM   8063 C  C   . GLY D 2 167 ? -49.481 -21.274 34.207  1    59.17  ? 337 GLY D C   1 
ATOM   8064 O  O   . GLY D 2 167 ? -48.406 -21.399 33.633  1    60.69  ? 337 GLY D O   1 
ATOM   8065 N  N   . GLU D 2 168 ? -49.616 -21.299 35.539  1    59.68  ? 338 GLU D N   1 
ATOM   8066 C  CA  . GLU D 2 168 ? -48.469 -21.413 36.423  1    57.51  ? 338 GLU D CA  1 
ATOM   8067 C  C   . GLU D 2 168 ? -47.852 -22.808 36.357  1    59.36  ? 338 GLU D C   1 
ATOM   8068 O  O   . GLU D 2 168 ? -46.635 -22.926 36.481  1    61.46  ? 338 GLU D O   1 
ATOM   8069 C  CB  . GLU D 2 168 ? -48.824 -21.08  37.864  1    55.45  ? 338 GLU D CB  1 
ATOM   8070 C  CG  . GLU D 2 168 ? -48.716 -19.592 38.162  1    54.93  ? 338 GLU D CG  1 
ATOM   8071 C  CD  . GLU D 2 168 ? -48.971 -19.293 39.622  1    57.09  ? 338 GLU D CD  1 
ATOM   8072 O  OE1 . GLU D 2 168 ? -48.369 -19.978 40.5    1    57.39  ? 338 GLU D OE1 1 
ATOM   8073 O  OE2 . GLU D 2 168 ? -49.77  -18.359 39.861  1    59.25  ? 338 GLU D OE2 1 
ATOM   8074 N  N   . LEU D 2 169 ? -48.667 -23.851 36.176  1    57.25  ? 339 LEU D N   1 
ATOM   8075 C  CA  . LEU D 2 169 ? -48.112 -25.187 36.022  1    58     ? 339 LEU D CA  1 
ATOM   8076 C  C   . LEU D 2 169 ? -47.163 -25.243 34.822  1    56.4   ? 339 LEU D C   1 
ATOM   8077 O  O   . LEU D 2 169 ? -46.159 -25.95  34.881  1    56.05  ? 339 LEU D O   1 
ATOM   8078 C  CB  . LEU D 2 169 ? -49.195 -26.263 35.945  1    60.72  ? 339 LEU D CB  1 
ATOM   8079 C  CG  . LEU D 2 169 ? -49.956 -26.595 37.235  1    62.18  ? 339 LEU D CG  1 
ATOM   8080 C  CD1 . LEU D 2 169 ? -50.891 -27.76  36.974  1    66.97  ? 339 LEU D CD1 1 
ATOM   8081 C  CD2 . LEU D 2 169 ? -49.029 -26.949 38.381  1    61.73  ? 339 LEU D CD2 1 
ATOM   8082 N  N   . SER D 2 170 ? -47.462 -24.492 33.75   1    55.73  ? 340 SER D N   1 
ATOM   8083 C  CA  . SER D 2 170 ? -46.626 -24.518 32.555  1    56.56  ? 340 SER D CA  1 
ATOM   8084 C  C   . SER D 2 170 ? -45.237 -23.926 32.819  1    60.58  ? 340 SER D C   1 
ATOM   8085 O  O   . SER D 2 170 ? -44.272 -24.293 32.143  1    65.08  ? 340 SER D O   1 
ATOM   8086 C  CB  . SER D 2 170 ? -47.283 -23.841 31.394  1    54.32  ? 340 SER D CB  1 
ATOM   8087 O  OG  . SER D 2 170 ? -47.241 -22.436 31.537  1    55.01  ? 340 SER D OG  1 
ATOM   8088 N  N   . LEU D 2 171 ? -45.123 -22.997 33.785  1    61.19  ? 341 LEU D N   1 
ATOM   8089 C  CA  . LEU D 2 171 ? -43.838 -22.375 34.107  1    56.57  ? 341 LEU D CA  1 
ATOM   8090 C  C   . LEU D 2 171 ? -42.796 -23.431 34.492  1    57.72  ? 341 LEU D C   1 
ATOM   8091 O  O   . LEU D 2 171 ? -41.604 -23.25  34.231  1    55.75  ? 341 LEU D O   1 
ATOM   8092 C  CB  . LEU D 2 171 ? -44.006 -21.344 35.222  1    53.21  ? 341 LEU D CB  1 
ATOM   8093 C  CG  . LEU D 2 171 ? -44.91  -20.139 34.938  1    52.34  ? 341 LEU D CG  1 
ATOM   8094 C  CD1 . LEU D 2 171 ? -44.895 -19.186 36.117  1    51.18  ? 341 LEU D CD1 1 
ATOM   8095 C  CD2 . LEU D 2 171 ? -44.474 -19.401 33.669  1    54.85  ? 341 LEU D CD2 1 
ATOM   8096 N  N   . ILE D 2 172 ? -43.259 -24.536 35.107  1    56.5   ? 342 ILE D N   1 
ATOM   8097 C  CA  . ILE D 2 172 ? -42.401 -25.513 35.772  1    55.94  ? 342 ILE D CA  1 
ATOM   8098 C  C   . ILE D 2 172 ? -41.628 -26.385 34.773  1    56.68  ? 342 ILE D C   1 
ATOM   8099 O  O   . ILE D 2 172 ? -40.508 -26.811 35.061  1    57.1   ? 342 ILE D O   1 
ATOM   8100 C  CB  . ILE D 2 172 ? -43.258 -26.398 36.691  1    57.31  ? 342 ILE D CB  1 
ATOM   8101 C  CG1 . ILE D 2 172 ? -43.967 -25.59  37.791  1    55.27  ? 342 ILE D CG1 1 
ATOM   8102 C  CG2 . ILE D 2 172 ? -42.439 -27.583 37.221  1    59.47  ? 342 ILE D CG2 1 
ATOM   8103 C  CD1 . ILE D 2 172 ? -43.103 -25.177 38.967  1    55.39  ? 342 ILE D CD1 1 
ATOM   8104 N  N   . ASP D 2 173 ? -42.274 -26.706 33.64   1    56.57  ? 343 ASP D N   1 
ATOM   8105 C  CA  . ASP D 2 173 ? -41.815 -27.72  32.707  1    58.23  ? 343 ASP D CA  1 
ATOM   8106 C  C   . ASP D 2 173 ? -41.463 -27.041 31.388  1    57.56  ? 343 ASP D C   1 
ATOM   8107 O  O   . ASP D 2 173 ? -42.371 -26.713 30.628  1    56.83  ? 343 ASP D O   1 
ATOM   8108 C  CB  . ASP D 2 173 ? -42.878 -28.787 32.493  1    59.38  ? 343 ASP D CB  1 
ATOM   8109 C  CG  . ASP D 2 173 ? -43.344 -29.508 33.747  1    63.08  ? 343 ASP D CG  1 
ATOM   8110 O  OD1 . ASP D 2 173 ? -42.48  -30.117 34.414  1    66.45  ? 343 ASP D OD1 1 
ATOM   8111 O  OD2 . ASP D 2 173 ? -44.555 -29.461 34.047  1    62.11  ? 343 ASP D OD2 1 
ATOM   8112 N  N   . ALA D 2 174 ? -40.156 -26.818 31.164  1    55.78  ? 344 ALA D N   1 
ATOM   8113 C  CA  . ALA D 2 174 ? -39.6   -26.235 29.946  1    56.97  ? 344 ALA D CA  1 
ATOM   8114 C  C   . ALA D 2 174 ? -39.935 -27.106 28.739  1    57.95  ? 344 ALA D C   1 
ATOM   8115 O  O   . ALA D 2 174 ? -40.114 -26.577 27.648  1    57.18  ? 344 ALA D O   1 
ATOM   8116 C  CB  . ALA D 2 174 ? -38.101 -26.088 30.062  1    56.01  ? 344 ALA D CB  1 
ATOM   8117 N  N   . ASP D 2 175 ? -39.939 -28.428 28.957  1    57.49  ? 345 ASP D N   1 
ATOM   8118 C  CA  . ASP D 2 175 ? -40.469 -29.399 28.024  1    59.84  ? 345 ASP D CA  1 
ATOM   8119 C  C   . ASP D 2 175 ? -41.839 -29.832 28.543  1    61.65  ? 345 ASP D C   1 
ATOM   8120 O  O   . ASP D 2 175 ? -41.925 -30.565 29.527  1    60.67  ? 345 ASP D O   1 
ATOM   8121 C  CB  . ASP D 2 175 ? -39.536 -30.595 27.855  1    62.95  ? 345 ASP D CB  1 
ATOM   8122 C  CG  . ASP D 2 175 ? -40.037 -31.725 26.954  1    67.15  ? 345 ASP D CG  1 
ATOM   8123 O  OD1 . ASP D 2 175 ? -41.143 -31.619 26.393  1    65.96  ? 345 ASP D OD1 1 
ATOM   8124 O  OD2 . ASP D 2 175 ? -39.334 -32.734 26.834  1    73.93  ? 345 ASP D OD2 1 
ATOM   8125 N  N   . PRO D 2 176 ? -42.961 -29.5   27.857  1    62.05  ? 346 PRO D N   1 
ATOM   8126 C  CA  . PRO D 2 176 ? -42.942 -28.916 26.509  1    60.87  ? 346 PRO D CA  1 
ATOM   8127 C  C   . PRO D 2 176 ? -43.094 -27.413 26.308  1    59.85  ? 346 PRO D C   1 
ATOM   8128 O  O   . PRO D 2 176 ? -43.081 -26.971 25.173  1    62.4   ? 346 PRO D O   1 
ATOM   8129 C  CB  . PRO D 2 176 ? -44.172 -29.651 25.933  1    60.18  ? 346 PRO D CB  1 
ATOM   8130 C  CG  . PRO D 2 176 ? -45.154 -29.669 27.075  1    59.13  ? 346 PRO D CG  1 
ATOM   8131 C  CD  . PRO D 2 176 ? -44.322 -29.802 28.323  1    59.44  ? 346 PRO D CD  1 
ATOM   8132 N  N   . TYR D 2 177 ? -43.225 -26.634 27.39   1    58.79  ? 347 TYR D N   1 
ATOM   8133 C  CA  . TYR D 2 177 ? -43.908 -25.349 27.317  1    57.78  ? 347 TYR D CA  1 
ATOM   8134 C  C   . TYR D 2 177 ? -43.057 -24.244 26.694  1    59.67  ? 347 TYR D C   1 
ATOM   8135 O  O   . TYR D 2 177 ? -43.58  -23.194 26.315  1    61.67  ? 347 TYR D O   1 
ATOM   8136 C  CB  . TYR D 2 177 ? -44.572 -25.019 28.66   1    53.78  ? 347 TYR D CB  1 
ATOM   8137 C  CG  . TYR D 2 177 ? -45.69  -25.996 28.979  1    59     ? 347 TYR D CG  1 
ATOM   8138 C  CD1 . TYR D 2 177 ? -46.85  -26.049 28.195  1    61.32  ? 347 TYR D CD1 1 
ATOM   8139 C  CD2 . TYR D 2 177 ? -45.553 -26.937 29.995  1    61.76  ? 347 TYR D CD2 1 
ATOM   8140 C  CE1 . TYR D 2 177 ? -47.854 -26.974 28.447  1    63.85  ? 347 TYR D CE1 1 
ATOM   8141 C  CE2 . TYR D 2 177 ? -46.552 -27.867 30.254  1    62.4   ? 347 TYR D CE2 1 
ATOM   8142 C  CZ  . TYR D 2 177 ? -47.701 -27.89  29.479  1    65.7   ? 347 TYR D CZ  1 
ATOM   8143 O  OH  . TYR D 2 177 ? -48.683 -28.81  29.757  1    70.11  ? 347 TYR D OH  1 
ATOM   8144 N  N   . LEU D 2 178 ? -41.749 -24.457 26.584  1    60.12  ? 348 LEU D N   1 
ATOM   8145 C  CA  . LEU D 2 178 ? -40.905 -23.457 25.943  1    64.67  ? 348 LEU D CA  1 
ATOM   8146 C  C   . LEU D 2 178 ? -41.246 -23.27  24.458  1    66.76  ? 348 LEU D C   1 
ATOM   8147 O  O   . LEU D 2 178 ? -40.884 -22.265 23.852  1    69.92  ? 348 LEU D O   1 
ATOM   8148 C  CB  . LEU D 2 178 ? -39.438 -23.852 26.101  1    64.35  ? 348 LEU D CB  1 
ATOM   8149 C  CG  . LEU D 2 178 ? -38.765 -23.487 27.425  1    60.13  ? 348 LEU D CG  1 
ATOM   8150 C  CD1 . LEU D 2 178 ? -37.284 -23.846 27.289  1    62.93  ? 348 LEU D CD1 1 
ATOM   8151 C  CD2 . LEU D 2 178 ? -38.975 -22.02  27.778  1    52.57  ? 348 LEU D CD2 1 
ATOM   8152 N  N   . LYS D 2 179 ? -41.921 -24.241 23.854  1    63.68  ? 349 LYS D N   1 
ATOM   8153 C  CA  . LYS D 2 179 ? -42.156 -24.132 22.429  1    68.9   ? 349 LYS D CA  1 
ATOM   8154 C  C   . LYS D 2 179 ? -43.518 -23.505 22.133  1    68.52  ? 349 LYS D C   1 
ATOM   8155 O  O   . LYS D 2 179 ? -43.875 -23.402 20.966  1    76.8   ? 349 LYS D O   1 
ATOM   8156 C  CB  . LYS D 2 179 ? -41.956 -25.48  21.728  1    70.09  ? 349 LYS D CB  1 
ATOM   8157 C  CG  . LYS D 2 179 ? -42.926 -26.582 22.144  1    70.95  ? 349 LYS D CG  1 
ATOM   8158 C  CD  . LYS D 2 179 ? -42.48  -27.972 21.683  1    73.17  ? 349 LYS D CD  1 
ATOM   8159 C  CE  . LYS D 2 179 ? -43.136 -29.066 22.461  1    76.56  ? 349 LYS D CE  1 
ATOM   8160 N  NZ  . LYS D 2 179 ? -43.21  -30.359 21.774  1    81.13  ? 349 LYS D NZ  1 
ATOM   8161 N  N   . TYR D 2 180 ? -44.267 -23.116 23.171  1    63.68  ? 350 TYR D N   1 
ATOM   8162 C  CA  . TYR D 2 180 ? -45.499 -22.357 23.025  1    61.64  ? 350 TYR D CA  1 
ATOM   8163 C  C   . TYR D 2 180 ? -45.306 -20.949 23.595  1    61.52  ? 350 TYR D C   1 
ATOM   8164 O  O   . TYR D 2 180 ? -44.673 -20.779 24.638  1    60.48  ? 350 TYR D O   1 
ATOM   8165 C  CB  . TYR D 2 180 ? -46.653 -23.056 23.747  1    65.98  ? 350 TYR D CB  1 
ATOM   8166 C  CG  . TYR D 2 180 ? -46.914 -24.512 23.365  1    69.39  ? 350 TYR D CG  1 
ATOM   8167 C  CD1 . TYR D 2 180 ? -47.291 -24.872 22.072  1    70.44  ? 350 TYR D CD1 1 
ATOM   8168 C  CD2 . TYR D 2 180 ? -46.811 -25.525 24.314  1    71.23  ? 350 TYR D CD2 1 
ATOM   8169 C  CE1 . TYR D 2 180 ? -47.522 -26.198 21.733  1    75.02  ? 350 TYR D CE1 1 
ATOM   8170 C  CE2 . TYR D 2 180 ? -47.074 -26.851 23.991  1    74.05  ? 350 TYR D CE2 1 
ATOM   8171 C  CZ  . TYR D 2 180 ? -47.422 -27.194 22.697  1    76.16  ? 350 TYR D CZ  1 
ATOM   8172 O  OH  . TYR D 2 180 ? -47.653 -28.513 22.407  1    80.14  ? 350 TYR D OH  1 
ATOM   8173 N  N   . LEU D 2 181 ? -45.848 -19.947 22.881  1    59.42  ? 351 LEU D N   1 
ATOM   8174 C  CA  . LEU D 2 181 ? -45.815 -18.544 23.253  1    58.04  ? 351 LEU D CA  1 
ATOM   8175 C  C   . LEU D 2 181 ? -46.758 -18.305 24.432  1    59.73  ? 351 LEU D C   1 
ATOM   8176 O  O   . LEU D 2 181 ? -47.736 -19.021 24.59   1    60.74  ? 351 LEU D O   1 
ATOM   8177 C  CB  . LEU D 2 181 ? -46.21  -17.657 22.073  1    58.15  ? 351 LEU D CB  1 
ATOM   8178 C  CG  . LEU D 2 181 ? -45.247 -17.541 20.885  1    55.54  ? 351 LEU D CG  1 
ATOM   8179 C  CD1 . LEU D 2 181 ? -45.892 -16.828 19.704  1    54.15  ? 351 LEU D CD1 1 
ATOM   8180 C  CD2 . LEU D 2 181 ? -43.963 -16.848 21.284  1    52.91  ? 351 LEU D CD2 1 
ATOM   8181 N  N   . PRO D 2 182 ? -46.515 -17.272 25.277  1    57.33  ? 352 PRO D N   1 
ATOM   8182 C  CA  . PRO D 2 182 ? -47.436 -16.935 26.37   1    56.73  ? 352 PRO D CA  1 
ATOM   8183 C  C   . PRO D 2 182 ? -48.901 -16.798 25.979  1    58.61  ? 352 PRO D C   1 
ATOM   8184 O  O   . PRO D 2 182 ? -49.761 -17.233 26.731  1    65.24  ? 352 PRO D O   1 
ATOM   8185 C  CB  . PRO D 2 182 ? -46.881 -15.593 26.882  1    53.63  ? 352 PRO D CB  1 
ATOM   8186 C  CG  . PRO D 2 182 ? -45.42  -15.676 26.567  1    50.59  ? 352 PRO D CG  1 
ATOM   8187 C  CD  . PRO D 2 182 ? -45.35  -16.375 25.212  1    51.14  ? 352 PRO D CD  1 
ATOM   8188 N  N   . SER D 2 183 ? -49.175 -16.175 24.824  1    58.19  ? 353 SER D N   1 
ATOM   8189 C  CA  . SER D 2 183 ? -50.534 -15.909 24.372  1    58.72  ? 353 SER D CA  1 
ATOM   8190 C  C   . SER D 2 183 ? -51.284 -17.219 24.14   1    63.2   ? 353 SER D C   1 
ATOM   8191 O  O   . SER D 2 183 ? -52.489 -17.306 24.415  1    70.16  ? 353 SER D O   1 
ATOM   8192 C  CB  . SER D 2 183 ? -50.531 -15.061 23.134  1    57.91  ? 353 SER D CB  1 
ATOM   8193 O  OG  . SER D 2 183 ? -49.861 -15.739 22.079  1    57.63  ? 353 SER D OG  1 
ATOM   8194 N  N   . VAL D 2 184 ? -50.559 -18.227 23.621  1    62.24  ? 354 VAL D N   1 
ATOM   8195 C  CA  . VAL D 2 184 ? -51.092 -19.552 23.334  1    60.62  ? 354 VAL D CA  1 
ATOM   8196 C  C   . VAL D 2 184 ? -51.355 -20.289 24.651  1    62.72  ? 354 VAL D C   1 
ATOM   8197 O  O   . VAL D 2 184 ? -52.479 -20.746 24.902  1    60.87  ? 354 VAL D O   1 
ATOM   8198 C  CB  . VAL D 2 184 ? -50.166 -20.351 22.397  1    59.82  ? 354 VAL D CB  1 
ATOM   8199 C  CG1 . VAL D 2 184 ? -50.57  -21.819 22.257  1    60.15  ? 354 VAL D CG1 1 
ATOM   8200 C  CG2 . VAL D 2 184 ? -50.045 -19.712 21.021  1    58.92  ? 354 VAL D CG2 1 
ATOM   8201 N  N   . ILE D 2 185 ? -50.324 -20.372 25.515  1    59.76  ? 355 ILE D N   1 
ATOM   8202 C  CA  . ILE D 2 185 ? -50.507 -21.043 26.794  1    61.14  ? 355 ILE D CA  1 
ATOM   8203 C  C   . ILE D 2 185 ? -51.66  -20.4   27.576  1    63.56  ? 355 ILE D C   1 
ATOM   8204 O  O   . ILE D 2 185 ? -52.414 -21.104 28.247  1    67.65  ? 355 ILE D O   1 
ATOM   8205 C  CB  . ILE D 2 185 ? -49.209 -21.108 27.609  1    58.78  ? 355 ILE D CB  1 
ATOM   8206 C  CG1 . ILE D 2 185 ? -48.141 -21.944 26.92   1    58.13  ? 355 ILE D CG1 1 
ATOM   8207 C  CG2 . ILE D 2 185 ? -49.487 -21.625 29.022  1    59.6   ? 355 ILE D CG2 1 
ATOM   8208 C  CD1 . ILE D 2 185 ? -46.788 -21.911 27.629  1    54     ? 355 ILE D CD1 1 
ATOM   8209 N  N   . ALA D 2 186 ? -51.812 -19.074 27.47   1    60.3   ? 356 ALA D N   1 
ATOM   8210 C  CA  . ALA D 2 186 ? -52.934 -18.364 28.073  1    60.24  ? 356 ALA D CA  1 
ATOM   8211 C  C   . ALA D 2 186 ? -54.284 -18.816 27.494  1    62.76  ? 356 ALA D C   1 
ATOM   8212 O  O   . ALA D 2 186 ? -55.222 -19.098 28.251  1    61.28  ? 356 ALA D O   1 
ATOM   8213 C  CB  . ALA D 2 186 ? -52.742 -16.877 27.919  1    58.68  ? 356 ALA D CB  1 
ATOM   8214 N  N   . ALA D 2 187 ? -54.395 -18.866 26.155  1    62.27  ? 357 ALA D N   1 
ATOM   8215 C  CA  . ALA D 2 187 ? -55.616 -19.345 25.514  1    65.51  ? 357 ALA D CA  1 
ATOM   8216 C  C   . ALA D 2 187 ? -55.939 -20.781 25.945  1    68.21  ? 357 ALA D C   1 
ATOM   8217 O  O   . ALA D 2 187 ? -57.073 -21.08  26.316  1    71.29  ? 357 ALA D O   1 
ATOM   8218 C  CB  . ALA D 2 187 ? -55.469 -19.235 24.018  1    66.37  ? 357 ALA D CB  1 
ATOM   8219 N  N   . ALA D 2 188 ? -54.935 -21.673 25.905  1    67.98  ? 358 ALA D N   1 
ATOM   8220 C  CA  . ALA D 2 188 ? -55.117 -23.073 26.24   1    70.47  ? 358 ALA D CA  1 
ATOM   8221 C  C   . ALA D 2 188 ? -55.547 -23.228 27.696  1    72.16  ? 358 ALA D C   1 
ATOM   8222 O  O   . ALA D 2 188 ? -56.358 -24.099 28.023  1    76.41  ? 358 ALA D O   1 
ATOM   8223 C  CB  . ALA D 2 188 ? -53.856 -23.848 25.933  1    68.65  ? 358 ALA D CB  1 
ATOM   8224 N  N   . ALA D 2 189 ? -54.977 -22.387 28.565  1    69.98  ? 359 ALA D N   1 
ATOM   8225 C  CA  . ALA D 2 189 ? -55.272 -22.439 29.986  1    70.41  ? 359 ALA D CA  1 
ATOM   8226 C  C   . ALA D 2 189 ? -56.686 -21.927 30.239  1    74.27  ? 359 ALA D C   1 
ATOM   8227 O  O   . ALA D 2 189 ? -57.37  -22.451 31.113  1    78.41  ? 359 ALA D O   1 
ATOM   8228 C  CB  . ALA D 2 189 ? -54.253 -21.653 30.772  1    66.2   ? 359 ALA D CB  1 
ATOM   8229 N  N   . PHE D 2 190 ? -57.099 -20.9   29.481  1    75.31  ? 360 PHE D N   1 
ATOM   8230 C  CA  . PHE D 2 190 ? -58.407 -20.285 29.639  1    77.83  ? 360 PHE D CA  1 
ATOM   8231 C  C   . PHE D 2 190 ? -59.511 -21.274 29.25   1    82.74  ? 360 PHE D C   1 
ATOM   8232 O  O   . PHE D 2 190 ? -60.402 -21.575 30.058  1    82.84  ? 360 PHE D O   1 
ATOM   8233 C  CB  . PHE D 2 190 ? -58.536 -19.004 28.814  1    74.4   ? 360 PHE D CB  1 
ATOM   8234 C  CG  . PHE D 2 190 ? -59.808 -18.228 29.117  1    75.46  ? 360 PHE D CG  1 
ATOM   8235 C  CD1 . PHE D 2 190 ? -60.167 -17.942 30.438  1    75.71  ? 360 PHE D CD1 1 
ATOM   8236 C  CD2 . PHE D 2 190 ? -60.65  -17.807 28.089  1    76.6   ? 360 PHE D CD2 1 
ATOM   8237 C  CE1 . PHE D 2 190 ? -61.331 -17.243 30.717  1    75.66  ? 360 PHE D CE1 1 
ATOM   8238 C  CE2 . PHE D 2 190 ? -61.794 -17.091 28.374  1    76.75  ? 360 PHE D CE2 1 
ATOM   8239 C  CZ  . PHE D 2 190 ? -62.136 -16.821 29.683  1    77.54  ? 360 PHE D CZ  1 
ATOM   8240 N  N   . HIS D 2 191 ? -59.436 -21.77  28.007  1    80.5   ? 361 HIS D N   1 
ATOM   8241 C  CA  . HIS D 2 191 ? -60.357 -22.791 27.548  1    84.03  ? 361 HIS D CA  1 
ATOM   8242 C  C   . HIS D 2 191 ? -60.488 -23.933 28.558  1    84.05  ? 361 HIS D C   1 
ATOM   8243 O  O   . HIS D 2 191 ? -61.591 -24.244 29.005  1    90     ? 361 HIS D O   1 
ATOM   8244 C  CB  . HIS D 2 191 ? -59.917 -23.372 26.207  1    86     ? 361 HIS D CB  1 
ATOM   8245 C  CG  . HIS D 2 191 ? -60.765 -24.55  25.88   1    92.06  ? 361 HIS D CG  1 
ATOM   8246 N  ND1 . HIS D 2 191 ? -61.967 -24.44  25.219  1    95.01  ? 361 HIS D ND1 1 
ATOM   8247 C  CD2 . HIS D 2 191 ? -60.637 -25.839 26.208  1    94.3   ? 361 HIS D CD2 1 
ATOM   8248 C  CE1 . HIS D 2 191 ? -62.515 -25.64  25.098  1    100.09 ? 361 HIS D CE1 1 
ATOM   8249 N  NE2 . HIS D 2 191 ? -61.728 -26.503 25.698  1    98.35  ? 361 HIS D NE2 1 
ATOM   8250 N  N   . LEU D 2 192 ? -59.366 -24.582 28.882  1    79.8   ? 362 LEU D N   1 
ATOM   8251 C  CA  . LEU D 2 192 ? -59.371 -25.765 29.726  1    83.41  ? 362 LEU D CA  1 
ATOM   8252 C  C   . LEU D 2 192 ? -60.025 -25.504 31.088  1    84.35  ? 362 LEU D C   1 
ATOM   8253 O  O   . LEU D 2 192 ? -60.626 -26.406 31.667  1    85.76  ? 362 LEU D O   1 
ATOM   8254 C  CB  . LEU D 2 192 ? -57.932 -26.263 29.854  1    83.47  ? 362 LEU D CB  1 
ATOM   8255 C  CG  . LEU D 2 192 ? -57.701 -27.477 30.768  1    88.13  ? 362 LEU D CG  1 
ATOM   8256 C  CD1 . LEU D 2 192 ? -58.623 -28.659 30.473  1    90.17  ? 362 LEU D CD1 1 
ATOM   8257 C  CD2 . LEU D 2 192 ? -56.244 -27.93  30.697  1    88.17  ? 362 LEU D CD2 1 
ATOM   8258 N  N   . ALA D 2 193 ? -59.89  -24.279 31.608  1    84.61  ? 363 ALA D N   1 
ATOM   8259 C  CA  . ALA D 2 193 ? -60.481 -23.914 32.888  1    88.34  ? 363 ALA D CA  1 
ATOM   8260 C  C   . ALA D 2 193 ? -61.978 -23.644 32.727  1    94.48  ? 363 ALA D C   1 
ATOM   8261 O  O   . ALA D 2 193 ? -62.791 -24.118 33.524  1    100.08 ? 363 ALA D O   1 
ATOM   8262 C  CB  . ALA D 2 193 ? -59.772 -22.708 33.465  1    81.78  ? 363 ALA D CB  1 
ATOM   8263 N  N   . LEU D 2 194 ? -62.319 -22.855 31.699  1    95.54  ? 364 LEU D N   1 
ATOM   8264 C  CA  . LEU D 2 194 ? -63.688 -22.504 31.363  1    100.21 ? 364 LEU D CA  1 
ATOM   8265 C  C   . LEU D 2 194 ? -64.504 -23.785 31.17   1    109.55 ? 364 LEU D C   1 
ATOM   8266 O  O   . LEU D 2 194 ? -65.608 -23.913 31.716  1    114.92 ? 364 LEU D O   1 
ATOM   8267 C  CB  . LEU D 2 194 ? -63.614 -21.639 30.101  1    97.21  ? 364 LEU D CB  1 
ATOM   8268 C  CG  . LEU D 2 194 ? -64.837 -20.789 29.748  1    100.33 ? 364 LEU D CG  1 
ATOM   8269 C  CD1 . LEU D 2 194 ? -65.122 -19.738 30.805  1    104.44 ? 364 LEU D CD1 1 
ATOM   8270 C  CD2 . LEU D 2 194 ? -64.647 -20.108 28.404  1    97.55  ? 364 LEU D CD2 1 
ATOM   8271 N  N   . TYR D 2 195 ? -63.926 -24.741 30.421  1    107.28 ? 365 TYR D N   1 
ATOM   8272 C  CA  . TYR D 2 195 ? -64.532 -26.029 30.104  1    106.13 ? 365 TYR D CA  1 
ATOM   8273 C  C   . TYR D 2 195 ? -64.753 -26.828 31.386  1    101.77 ? 365 TYR D C   1 
ATOM   8274 O  O   . TYR D 2 195 ? -65.855 -27.305 31.632  1    102.22 ? 365 TYR D O   1 
ATOM   8275 C  CB  . TYR D 2 195 ? -63.677 -26.798 29.085  1    107.5  ? 365 TYR D CB  1 
ATOM   8276 C  CG  . TYR D 2 195 ? -64.236 -28.129 28.591  1    114.58 ? 365 TYR D CG  1 
ATOM   8277 C  CD1 . TYR D 2 195 ? -65.198 -28.202 27.575  1    121.37 ? 365 TYR D CD1 1 
ATOM   8278 C  CD2 . TYR D 2 195 ? -63.802 -29.329 29.144  1    115.83 ? 365 TYR D CD2 1 
ATOM   8279 C  CE1 . TYR D 2 195 ? -65.702 -29.421 27.116  1    123.25 ? 365 TYR D CE1 1 
ATOM   8280 C  CE2 . TYR D 2 195 ? -64.293 -30.549 28.693  1    118.2  ? 365 TYR D CE2 1 
ATOM   8281 C  CZ  . TYR D 2 195 ? -65.244 -30.599 27.686  1    121.84 ? 365 TYR D CZ  1 
ATOM   8282 O  OH  . TYR D 2 195 ? -65.72  -31.808 27.281  1    130.09 ? 365 TYR D OH  1 
ATOM   8283 N  N   . THR D 2 196 ? -63.697 -26.954 32.201  1    94.01  ? 366 THR D N   1 
ATOM   8284 C  CA  . THR D 2 196 ? -63.75  -27.725 33.435  1    93.56  ? 366 THR D CA  1 
ATOM   8285 C  C   . THR D 2 196 ? -64.855 -27.22  34.363  1    96.01  ? 366 THR D C   1 
ATOM   8286 O  O   . THR D 2 196 ? -65.537 -28.025 34.992  1    97.26  ? 366 THR D O   1 
ATOM   8287 C  CB  . THR D 2 196 ? -62.401 -27.737 34.151  1    89.77  ? 366 THR D CB  1 
ATOM   8288 O  OG1 . THR D 2 196 ? -61.466 -28.345 33.267  1    92.24  ? 366 THR D OG1 1 
ATOM   8289 C  CG2 . THR D 2 196 ? -62.421 -28.495 35.469  1    86.23  ? 366 THR D CG2 1 
ATOM   8290 N  N   . VAL D 2 197 ? -65.032 -25.899 34.451  1    96.24  ? 367 VAL D N   1 
ATOM   8291 C  CA  . VAL D 2 197 ? -65.919 -25.339 35.459  1    101.33 ? 367 VAL D CA  1 
ATOM   8292 C  C   . VAL D 2 197 ? -67.334 -25.167 34.918  1    106.75 ? 367 VAL D C   1 
ATOM   8293 O  O   . VAL D 2 197 ? -68.281 -25.514 35.611  1    113.49 ? 367 VAL D O   1 
ATOM   8294 C  CB  . VAL D 2 197 ? -65.394 -24.025 36.058  1    102.17 ? 367 VAL D CB  1 
ATOM   8295 C  CG1 . VAL D 2 197 ? -66.453 -23.318 36.901  1    104.29 ? 367 VAL D CG1 1 
ATOM   8296 C  CG2 . VAL D 2 197 ? -64.1   -24.234 36.84   1    99.13  ? 367 VAL D CG2 1 
ATOM   8297 N  N   . THR D 2 198 ? -67.481 -24.63  33.697  1    109.7  ? 368 THR D N   1 
ATOM   8298 C  CA  . THR D 2 198 ? -68.796 -24.276 33.175  1    114.72 ? 368 THR D CA  1 
ATOM   8299 C  C   . THR D 2 198 ? -69.256 -25.205 32.047  1    115.95 ? 368 THR D C   1 
ATOM   8300 O  O   . THR D 2 198 ? -70.432 -25.186 31.689  1    118.68 ? 368 THR D O   1 
ATOM   8301 C  CB  . THR D 2 198 ? -68.822 -22.812 32.731  1    115.68 ? 368 THR D CB  1 
ATOM   8302 O  OG1 . THR D 2 198 ? -67.954 -22.641 31.612  1    115.87 ? 368 THR D OG1 1 
ATOM   8303 C  CG2 . THR D 2 198 ? -68.437 -21.849 33.837  1    111.93 ? 368 THR D CG2 1 
ATOM   8304 N  N   . GLY D 2 199 ? -68.339 -25.986 31.459  1    113.52 ? 369 GLY D N   1 
ATOM   8305 C  CA  . GLY D 2 199 ? -68.677 -26.841 30.325  1    115.25 ? 369 GLY D CA  1 
ATOM   8306 C  C   . GLY D 2 199 ? -68.485 -26.127 28.984  1    113.57 ? 369 GLY D C   1 
ATOM   8307 O  O   . GLY D 2 199 ? -68.508 -26.75  27.924  1    111.85 ? 369 GLY D O   1 
ATOM   8308 N  N   . GLN D 2 200 ? -68.267 -24.811 29.058  1    113.76 ? 370 GLN D N   1 
ATOM   8309 C  CA  . GLN D 2 200 ? -68.212 -23.929 27.903  1    115.8  ? 370 GLN D CA  1 
ATOM   8310 C  C   . GLN D 2 200 ? -66.836 -23.983 27.238  1    110.32 ? 370 GLN D C   1 
ATOM   8311 O  O   . GLN D 2 200 ? -65.925 -24.653 27.722  1    103.71 ? 370 GLN D O   1 
ATOM   8312 C  CB  . GLN D 2 200 ? -68.483 -22.502 28.374  1    123.04 ? 370 GLN D CB  1 
ATOM   8313 C  CG  . GLN D 2 200 ? -69.869 -22.309 28.978  1    126.95 ? 370 GLN D CG  1 
ATOM   8314 C  CD  . GLN D 2 200 ? -70.059 -20.918 29.532  1    126.54 ? 370 GLN D CD  1 
ATOM   8315 O  OE1 . GLN D 2 200 ? -69.608 -19.92  28.961  1    125.27 ? 370 GLN D OE1 1 
ATOM   8316 N  NE2 . GLN D 2 200 ? -70.691 -20.852 30.691  1    128.66 ? 370 GLN D NE2 1 
ATOM   8317 N  N   . SER D 2 201 ? -66.71  -23.257 26.118  1    106.93 ? 371 SER D N   1 
ATOM   8318 C  CA  . SER D 2 201 ? -65.535 -23.301 25.266  1    103.49 ? 371 SER D CA  1 
ATOM   8319 C  C   . SER D 2 201 ? -64.959 -21.906 25.082  1    105.3  ? 371 SER D C   1 
ATOM   8320 O  O   . SER D 2 201 ? -65.589 -20.913 25.445  1    108.29 ? 371 SER D O   1 
ATOM   8321 C  CB  . SER D 2 201 ? -65.814 -23.926 23.93   1    104.14 ? 371 SER D CB  1 
ATOM   8322 O  OG  . SER D 2 201 ? -65.612 -25.328 23.992  1    105.41 ? 371 SER D OG  1 
ATOM   8323 N  N   . TRP D 2 202 ? -63.729 -21.891 24.55   1    103.07 ? 372 TRP D N   1 
ATOM   8324 C  CA  . TRP D 2 202 ? -63.035 -20.736 24.002  1    97.36  ? 372 TRP D CA  1 
ATOM   8325 C  C   . TRP D 2 202 ? -64.027 -19.904 23.187  1    100.2  ? 372 TRP D C   1 
ATOM   8326 O  O   . TRP D 2 202 ? -64.43  -20.305 22.096  1    101.23 ? 372 TRP D O   1 
ATOM   8327 C  CB  . TRP D 2 202 ? -61.855 -21.265 23.163  1    92.74  ? 372 TRP D CB  1 
ATOM   8328 C  CG  . TRP D 2 202 ? -60.973 -20.263 22.47   1    87.23  ? 372 TRP D CG  1 
ATOM   8329 C  CD1 . TRP D 2 202 ? -60.817 -20.103 21.121  1    88.46  ? 372 TRP D CD1 1 
ATOM   8330 C  CD2 . TRP D 2 202 ? -60.087 -19.307 23.092  1    83.89  ? 372 TRP D CD2 1 
ATOM   8331 N  NE1 . TRP D 2 202 ? -59.909 -19.107 20.86   1    90.05  ? 372 TRP D NE1 1 
ATOM   8332 C  CE2 . TRP D 2 202 ? -59.444 -18.6   22.048  1    82.47  ? 372 TRP D CE2 1 
ATOM   8333 C  CE3 . TRP D 2 202 ? -59.787 -18.977 24.419  1    80.75  ? 372 TRP D CE3 1 
ATOM   8334 C  CZ2 . TRP D 2 202 ? -58.535 -17.581 22.292  1    76.88  ? 372 TRP D CZ2 1 
ATOM   8335 C  CZ3 . TRP D 2 202 ? -58.89  -17.964 24.662  1    77.97  ? 372 TRP D CZ3 1 
ATOM   8336 C  CH2 . TRP D 2 202 ? -58.276 -17.283 23.61   1    77.69  ? 372 TRP D CH2 1 
ATOM   8337 N  N   . PRO D 2 203 ? -64.466 -18.73  23.706  1    102.78 ? 373 PRO D N   1 
ATOM   8338 C  CA  . PRO D 2 203 ? -65.541 -17.957 23.076  1    102.55 ? 373 PRO D CA  1 
ATOM   8339 C  C   . PRO D 2 203 ? -65.15  -17.388 21.714  1    100.42 ? 373 PRO D C   1 
ATOM   8340 O  O   . PRO D 2 203 ? -63.976 -17.164 21.435  1    95.75  ? 373 PRO D O   1 
ATOM   8341 C  CB  . PRO D 2 203 ? -65.879 -16.852 24.099  1    103.44 ? 373 PRO D CB  1 
ATOM   8342 C  CG  . PRO D 2 203 ? -64.628 -16.73  24.967  1    99.68  ? 373 PRO D CG  1 
ATOM   8343 C  CD  . PRO D 2 203 ? -63.936 -18.083 24.926  1    99.72  ? 373 PRO D CD  1 
ATOM   8344 N  N   . GLU D 2 204 ? -66.158 -17.181 20.864  1    102.49 ? 374 GLU D N   1 
ATOM   8345 C  CA  . GLU D 2 204 ? -65.943 -16.719 19.506  1    100.4  ? 374 GLU D CA  1 
ATOM   8346 C  C   . GLU D 2 204 ? -65.232 -15.363 19.507  1    95.53  ? 374 GLU D C   1 
ATOM   8347 O  O   . GLU D 2 204 ? -64.296 -15.162 18.74   1    91.15  ? 374 GLU D O   1 
ATOM   8348 C  CB  . GLU D 2 204 ? -67.287 -16.723 18.777  1    103.22 ? 374 GLU D CB  1 
ATOM   8349 C  CG  . GLU D 2 204 ? -67.201 -16.186 17.35   1    108.97 ? 374 GLU D CG  1 
ATOM   8350 C  CD  . GLU D 2 204 ? -66.383 -16.998 16.357  1    110.57 ? 374 GLU D CD  1 
ATOM   8351 O  OE1 . GLU D 2 204 ? -66.022 -18.154 16.667  1    108.76 ? 374 GLU D OE1 1 
ATOM   8352 O  OE2 . GLU D 2 204 ? -66.106 -16.461 15.26   1    112.47 ? 374 GLU D OE2 1 
ATOM   8353 N  N   . SER D 2 205 ? -65.678 -14.453 20.388  1    94.12  ? 375 SER D N   1 
ATOM   8354 C  CA  . SER D 2 205 ? -65.154 -13.099 20.52   1    93.92  ? 375 SER D CA  1 
ATOM   8355 C  C   . SER D 2 205 ? -63.626 -13.084 20.708  1    91.61  ? 375 SER D C   1 
ATOM   8356 O  O   . SER D 2 205 ? -62.926 -12.184 20.206  1    87.38  ? 375 SER D O   1 
ATOM   8357 C  CB  . SER D 2 205 ? -65.855 -12.388 21.647  1    92.88  ? 375 SER D CB  1 
ATOM   8358 O  OG  . SER D 2 205 ? -65.661 -13.083 22.872  1    90.88  ? 375 SER D OG  1 
ATOM   8359 N  N   . LEU D 2 206 ? -63.113 -14.097 21.426  1    90.11  ? 376 LEU D N   1 
ATOM   8360 C  CA  . LEU D 2 206 ? -61.68  -14.279 21.621  1    86.02  ? 376 LEU D CA  1 
ATOM   8361 C  C   . LEU D 2 206 ? -61.017 -14.902 20.391  1    84.24  ? 376 LEU D C   1 
ATOM   8362 O  O   . LEU D 2 206 ? -59.846 -14.637 20.15   1    84.92  ? 376 LEU D O   1 
ATOM   8363 C  CB  . LEU D 2 206 ? -61.39  -15.099 22.876  1    86.71  ? 376 LEU D CB  1 
ATOM   8364 C  CG  . LEU D 2 206 ? -61.527 -14.365 24.219  1    88     ? 376 LEU D CG  1 
ATOM   8365 C  CD1 . LEU D 2 206 ? -61.211 -15.311 25.377  1    86.21  ? 376 LEU D CD1 1 
ATOM   8366 C  CD2 . LEU D 2 206 ? -60.654 -13.114 24.29   1    85.83  ? 376 LEU D CD2 1 
ATOM   8367 N  N   . VAL D 2 207 ? -61.744 -15.733 19.634  1    84.56  ? 377 VAL D N   1 
ATOM   8368 C  CA  . VAL D 2 207 ? -61.252 -16.213 18.351  1    87.01  ? 377 VAL D CA  1 
ATOM   8369 C  C   . VAL D 2 207 ? -60.987 -15.014 17.438  1    87.53  ? 377 VAL D C   1 
ATOM   8370 O  O   . VAL D 2 207 ? -60.032 -15.015 16.657  1    85.38  ? 377 VAL D O   1 
ATOM   8371 C  CB  . VAL D 2 207 ? -62.208 -17.223 17.662  1    95.07  ? 377 VAL D CB  1 
ATOM   8372 C  CG1 . VAL D 2 207 ? -61.747 -17.628 16.259  1    90.48  ? 377 VAL D CG1 1 
ATOM   8373 C  CG2 . VAL D 2 207 ? -62.467 -18.465 18.511  1    97.46  ? 377 VAL D CG2 1 
ATOM   8374 N  N   . GLN D 2 208 ? -61.854 -13.996 17.514  1    90.37  ? 378 GLN D N   1 
ATOM   8375 C  CA  . GLN D 2 208 ? -61.772 -12.858 16.611  1    91.43  ? 378 GLN D CA  1 
ATOM   8376 C  C   . GLN D 2 208 ? -60.606 -11.945 16.997  1    90.94  ? 378 GLN D C   1 
ATOM   8377 O  O   . GLN D 2 208 ? -59.891 -11.455 16.124  1    89.5   ? 378 GLN D O   1 
ATOM   8378 C  CB  . GLN D 2 208 ? -63.118 -12.144 16.584  1    95.44  ? 378 GLN D CB  1 
ATOM   8379 C  CG  . GLN D 2 208 ? -64.132 -12.845 15.696  1    104.62 ? 378 GLN D CG  1 
ATOM   8380 C  CD  . GLN D 2 208 ? -63.59  -13.014 14.294  1    110.22 ? 378 GLN D CD  1 
ATOM   8381 O  OE1 . GLN D 2 208 ? -63.52  -14.128 13.758  1    108.14 ? 378 GLN D OE1 1 
ATOM   8382 N  NE2 . GLN D 2 208 ? -63.146 -11.904 13.717  1    111.76 ? 378 GLN D NE2 1 
ATOM   8383 N  N   . LYS D 2 209 ? -60.425 -11.732 18.31   1    87.58  ? 379 LYS D N   1 
ATOM   8384 C  CA  . LYS D 2 209 ? -59.333 -10.946 18.864  1    84.31  ? 379 LYS D CA  1 
ATOM   8385 C  C   . LYS D 2 209 ? -57.964 -11.558 18.534  1    81.56  ? 379 LYS D C   1 
ATOM   8386 O  O   . LYS D 2 209 ? -57.104 -10.872 17.99   1    79.1   ? 379 LYS D O   1 
ATOM   8387 C  CB  . LYS D 2 209 ? -59.534 -10.868 20.382  1    86.97  ? 379 LYS D CB  1 
ATOM   8388 C  CG  . LYS D 2 209 ? -58.619 -9.895  21.152  1    88.5   ? 379 LYS D CG  1 
ATOM   8389 C  CD  . LYS D 2 209 ? -58.721 -10.034 22.676  1    87.18  ? 379 LYS D CD  1 
ATOM   8390 C  CE  . LYS D 2 209 ? -57.812 -9.126  23.395  1    80.75  ? 379 LYS D CE  1 
ATOM   8391 N  NZ  . LYS D 2 209 ? -58.105 -7.745  22.993  1    86.24  ? 379 LYS D NZ  1 
ATOM   8392 N  N   . THR D 2 210 ? -57.77  -12.845 18.863  1    79.76  ? 380 THR D N   1 
ATOM   8393 C  CA  . THR D 2 210 ? -56.465 -13.502 18.893  1    79.51  ? 380 THR D CA  1 
ATOM   8394 C  C   . THR D 2 210 ? -56.108 -14.197 17.571  1    81.56  ? 380 THR D C   1 
ATOM   8395 O  O   . THR D 2 210 ? -54.943 -14.509 17.317  1    84.82  ? 380 THR D O   1 
ATOM   8396 C  CB  . THR D 2 210 ? -56.408 -14.53  20.031  1    79.39  ? 380 THR D CB  1 
ATOM   8397 O  OG1 . THR D 2 210 ? -57.264 -15.612 19.658  1    82.26  ? 380 THR D OG1 1 
ATOM   8398 C  CG2 . THR D 2 210 ? -56.769 -13.957 21.392  1    74.6   ? 380 THR D CG2 1 
ATOM   8399 N  N   . GLY D 2 211 ? -57.105 -14.51  16.749  1    83.17  ? 381 GLY D N   1 
ATOM   8400 C  CA  . GLY D 2 211 ? -56.856 -15.276 15.544  1    84.03  ? 381 GLY D CA  1 
ATOM   8401 C  C   . GLY D 2 211 ? -56.588 -16.746 15.865  1    86.38  ? 381 GLY D C   1 
ATOM   8402 O  O   . GLY D 2 211 ? -56.203 -17.488 14.968  1    87.02  ? 381 GLY D O   1 
ATOM   8403 N  N   . TYR D 2 212 ? -56.822 -17.154 17.128  1    86.3   ? 382 TYR D N   1 
ATOM   8404 C  CA  . TYR D 2 212 ? -56.648 -18.527 17.592  1    85.58  ? 382 TYR D CA  1 
ATOM   8405 C  C   . TYR D 2 212 ? -57.982 -19.289 17.599  1    88.77  ? 382 TYR D C   1 
ATOM   8406 O  O   . TYR D 2 212 ? -59     -18.802 18.103  1    87.69  ? 382 TYR D O   1 
ATOM   8407 C  CB  . TYR D 2 212 ? -56.049 -18.577 18.998  1    79.71  ? 382 TYR D CB  1 
ATOM   8408 C  CG  . TYR D 2 212 ? -54.639 -18.031 19.157  1    78.84  ? 382 TYR D CG  1 
ATOM   8409 C  CD1 . TYR D 2 212 ? -53.732 -18.033 18.098  1    76.8   ? 382 TYR D CD1 1 
ATOM   8410 C  CD2 . TYR D 2 212 ? -54.224 -17.489 20.372  1    73.53  ? 382 TYR D CD2 1 
ATOM   8411 C  CE1 . TYR D 2 212 ? -52.459 -17.498 18.242  1    72.98  ? 382 TYR D CE1 1 
ATOM   8412 C  CE2 . TYR D 2 212 ? -52.952 -16.964 20.524  1    71.19  ? 382 TYR D CE2 1 
ATOM   8413 C  CZ  . TYR D 2 212 ? -52.057 -16.972 19.462  1    71.6   ? 382 TYR D CZ  1 
ATOM   8414 O  OH  . TYR D 2 212 ? -50.781 -16.481 19.625  1    63.82  ? 382 TYR D OH  1 
ATOM   8415 N  N   . THR D 2 213 ? -57.944 -20.515 17.057  1    89.63  ? 383 THR D N   1 
ATOM   8416 C  CA  . THR D 2 213 ? -59.071 -21.437 17.078  1    93.2   ? 383 THR D CA  1 
ATOM   8417 C  C   . THR D 2 213 ? -58.675 -22.654 17.909  1    93.91  ? 383 THR D C   1 
ATOM   8418 O  O   . THR D 2 213 ? -57.487 -22.94  18.066  1    92.57  ? 383 THR D O   1 
ATOM   8419 C  CB  . THR D 2 213 ? -59.481 -21.859 15.664  1    93.55  ? 383 THR D CB  1 
ATOM   8420 O  OG1 . THR D 2 213 ? -58.593 -22.875 15.212  1    95.85  ? 383 THR D OG1 1 
ATOM   8421 C  CG2 . THR D 2 213 ? -59.506 -20.712 14.667  1    93.4   ? 383 THR D CG2 1 
ATOM   8422 N  N   . LEU D 2 214 ? -59.681 -23.383 18.406  1    93.8   ? 384 LEU D N   1 
ATOM   8423 C  CA  . LEU D 2 214 ? -59.416 -24.618 19.122  1    93.75  ? 384 LEU D CA  1 
ATOM   8424 C  C   . LEU D 2 214 ? -58.562 -25.547 18.249  1    95.56  ? 384 LEU D C   1 
ATOM   8425 O  O   . LEU D 2 214 ? -57.75  -26.318 18.765  1    94.67  ? 384 LEU D O   1 
ATOM   8426 C  CB  . LEU D 2 214 ? -60.745 -25.222 19.579  1    92.45  ? 384 LEU D CB  1 
ATOM   8427 C  CG  . LEU D 2 214 ? -61.471 -24.471 20.702  1    89.43  ? 384 LEU D CG  1 
ATOM   8428 C  CD1 . LEU D 2 214 ? -62.928 -24.855 20.812  1    93.72  ? 384 LEU D CD1 1 
ATOM   8429 C  CD2 . LEU D 2 214 ? -60.816 -24.755 22.033  1    88.71  ? 384 LEU D CD2 1 
ATOM   8430 N  N   . GLU D 2 215 ? -58.698 -25.424 16.919  1    97.64  ? 385 GLU D N   1 
ATOM   8431 C  CA  . GLU D 2 215 ? -57.828 -26.127 15.986  1    99.03  ? 385 GLU D CA  1 
ATOM   8432 C  C   . GLU D 2 215 ? -56.371 -25.73  16.255  1    96.24  ? 385 GLU D C   1 
ATOM   8433 O  O   . GLU D 2 215 ? -55.563 -26.588 16.6    1    92.76  ? 385 GLU D O   1 
ATOM   8434 C  CB  . GLU D 2 215 ? -58.338 -26.004 14.548  1    101.91 ? 385 GLU D CB  1 
ATOM   8435 C  CG  . GLU D 2 215 ? -57.657 -26.969 13.586  1    107.65 ? 385 GLU D CG  1 
ATOM   8436 C  CD  . GLU D 2 215 ? -58.43  -27.298 12.329  1    121.49 ? 385 GLU D CD  1 
ATOM   8437 O  OE1 . GLU D 2 215 ? -59.449 -28.008 12.449  1    130.67 ? 385 GLU D OE1 1 
ATOM   8438 O  OE2 . GLU D 2 215 ? -58.012 -26.867 11.233  1    126.15 ? 385 GLU D OE2 1 
ATOM   8439 N  N   . THR D 2 216 ? -56.049 -24.428 16.157  1    94.29  ? 386 THR D N   1 
ATOM   8440 C  CA  . THR D 2 216 ? -54.681 -23.95  16.316  1    95.09  ? 386 THR D CA  1 
ATOM   8441 C  C   . THR D 2 216 ? -54.179 -24.148 17.749  1    89.16  ? 386 THR D C   1 
ATOM   8442 O  O   . THR D 2 216 ? -52.979 -24.269 17.957  1    86.1   ? 386 THR D O   1 
ATOM   8443 C  CB  . THR D 2 216 ? -54.536 -22.503 15.839  1    99.34  ? 386 THR D CB  1 
ATOM   8444 O  OG1 . THR D 2 216 ? -55.563 -21.746 16.481  1    104.32 ? 386 THR D OG1 1 
ATOM   8445 C  CG2 . THR D 2 216 ? -54.643 -22.391 14.324  1    99.09  ? 386 THR D CG2 1 
ATOM   8446 N  N   . LEU D 2 217 ? -55.102 -24.227 18.718  1    86.1   ? 387 LEU D N   1 
ATOM   8447 C  CA  . LEU D 2 217 ? -54.768 -24.386 20.126  1    79.42  ? 387 LEU D CA  1 
ATOM   8448 C  C   . LEU D 2 217 ? -54.607 -25.858 20.523  1    82.43  ? 387 LEU D C   1 
ATOM   8449 O  O   . LEU D 2 217 ? -54.253 -26.149 21.659  1    83.35  ? 387 LEU D O   1 
ATOM   8450 C  CB  . LEU D 2 217 ? -55.846 -23.732 20.989  1    77.09  ? 387 LEU D CB  1 
ATOM   8451 C  CG  . LEU D 2 217 ? -55.933 -22.201 20.987  1    73.91  ? 387 LEU D CG  1 
ATOM   8452 C  CD1 . LEU D 2 217 ? -56.941 -21.759 22.038  1    71.89  ? 387 LEU D CD1 1 
ATOM   8453 C  CD2 . LEU D 2 217 ? -54.589 -21.54  21.246  1    70.05  ? 387 LEU D CD2 1 
ATOM   8454 N  N   . LYS D 2 218 ? -54.897 -26.806 19.634  1    85.01  ? 388 LYS D N   1 
ATOM   8455 C  CA  . LYS D 2 218 ? -54.983 -28.201 20.045  1    90.26  ? 388 LYS D CA  1 
ATOM   8456 C  C   . LYS D 2 218 ? -53.664 -28.697 20.653  1    87.5   ? 388 LYS D C   1 
ATOM   8457 O  O   . LYS D 2 218 ? -53.65  -29.261 21.75   1    89.43  ? 388 LYS D O   1 
ATOM   8458 C  CB  . LYS D 2 218 ? -55.409 -29.099 18.872  1    96.84  ? 388 LYS D CB  1 
ATOM   8459 C  CG  . LYS D 2 218 ? -55.36  -30.608 19.142  1    106.11 ? 388 LYS D CG  1 
ATOM   8460 C  CD  . LYS D 2 218 ? -54.681 -31.387 18.016  1    115.62 ? 388 LYS D CD  1 
ATOM   8461 C  CE  . LYS D 2 218 ? -53.202 -31.563 18.256  1    114.54 ? 388 LYS D CE  1 
ATOM   8462 N  NZ  . LYS D 2 218 ? -52.387 -31.388 17.054  1    114.32 ? 388 LYS D NZ  1 
ATOM   8463 N  N   . PRO D 2 219 ? -52.492 -28.581 19.982  1    84.72  ? 389 PRO D N   1 
ATOM   8464 C  CA  . PRO D 2 219 ? -51.282 -29.137 20.564  1    84.32  ? 389 PRO D CA  1 
ATOM   8465 C  C   . PRO D 2 219 ? -51.094 -28.754 22.022  1    82.89  ? 389 PRO D C   1 
ATOM   8466 O  O   . PRO D 2 219 ? -50.875 -29.649 22.86   1    84.93  ? 389 PRO D O   1 
ATOM   8467 C  CB  . PRO D 2 219 ? -50.212 -28.532 19.67   1    82.43  ? 389 PRO D CB  1 
ATOM   8468 C  CG  . PRO D 2 219 ? -50.853 -28.5   18.316  1    83.85  ? 389 PRO D CG  1 
ATOM   8469 C  CD  . PRO D 2 219 ? -52.219 -27.964 18.663  1    83.54  ? 389 PRO D CD  1 
ATOM   8470 N  N   . CYS D 2 220 ? -51.163 -27.455 22.319  1    77.75  ? 390 CYS D N   1 
ATOM   8471 C  CA  . CYS D 2 220 ? -50.928 -26.972 23.703  1    72.49  ? 390 CYS D CA  1 
ATOM   8472 C  C   . CYS D 2 220 ? -52.057 -27.478 24.602  1    74.38  ? 390 CYS D C   1 
ATOM   8473 O  O   . CYS D 2 220 ? -51.763 -27.951 25.708  1    73.19  ? 390 CYS D O   1 
ATOM   8474 C  CB  . CYS D 2 220 ? -50.824 -25.451 23.745  1    70.52  ? 390 CYS D CB  1 
ATOM   8475 S  SG  . CYS D 2 220 ? -50.286 -24.791 25.341  1    65.73  ? 390 CYS D SG  1 
ATOM   8476 N  N   . LEU D 2 221 ? -53.294 -27.399 24.122  1    77.33  ? 391 LEU D N   1 
ATOM   8477 C  CA  . LEU D 2 221 ? -54.438 -27.822 24.961  1    80.12  ? 391 LEU D CA  1 
ATOM   8478 C  C   . LEU D 2 221 ? -54.22  -29.281 25.366  1    80.97  ? 391 LEU D C   1 
ATOM   8479 O  O   . LEU D 2 221 ? -54.496 -29.627 26.526  1    80.19  ? 391 LEU D O   1 
ATOM   8480 C  CB  . LEU D 2 221 ? -55.746 -27.614 24.208  1    85.91  ? 391 LEU D CB  1 
ATOM   8481 C  CG  . LEU D 2 221 ? -56.597 -26.441 24.697  1    91.86  ? 391 LEU D CG  1 
ATOM   8482 C  CD1 . LEU D 2 221 ? -57.601 -26.005 23.651  1    91.64  ? 391 LEU D CD1 1 
ATOM   8483 C  CD2 . LEU D 2 221 ? -57.285 -26.813 25.995  1    91.84  ? 391 LEU D CD2 1 
ATOM   8484 N  N   . LEU D 2 222 ? -53.702 -30.085 24.446  1    84.2   ? 392 LEU D N   1 
ATOM   8485 C  CA  . LEU D 2 222 ? -53.412 -31.502 24.768  1    88.73  ? 392 LEU D CA  1 
ATOM   8486 C  C   . LEU D 2 222 ? -52.342 -31.546 25.861  1    86.55  ? 392 LEU D C   1 
ATOM   8487 O  O   . LEU D 2 222 ? -52.64  -32.049 26.952  1    91.11  ? 392 LEU D O   1 
ATOM   8488 C  CB  . LEU D 2 222 ? -52.956 -32.212 23.497  1    86.81  ? 392 LEU D CB  1 
ATOM   8489 C  CG  . LEU D 2 222 ? -54.045 -32.484 22.457  1    90.35  ? 392 LEU D CG  1 
ATOM   8490 C  CD1 . LEU D 2 222 ? -53.561 -33.503 21.446  1    88.47  ? 392 LEU D CD1 1 
ATOM   8491 C  CD2 . LEU D 2 222 ? -55.322 -32.958 23.124  1    89.3   ? 392 LEU D CD2 1 
ATOM   8492 N  N   . ASP D 2 223 ? -51.159 -31.01  25.573  1    81.27  ? 393 ASP D N   1 
ATOM   8493 C  CA  . ASP D 2 223 ? -50.056 -30.988 26.566  1    76.95  ? 393 ASP D CA  1 
ATOM   8494 C  C   . ASP D 2 223 ? -50.566 -30.45  27.902  1    75.1   ? 393 ASP D C   1 
ATOM   8495 O  O   . ASP D 2 223 ? -50.199 -31.019 28.946  1    71.52  ? 393 ASP D O   1 
ATOM   8496 C  CB  . ASP D 2 223 ? -48.883 -30.184 26.033  1    74.01  ? 393 ASP D CB  1 
ATOM   8497 C  CG  . ASP D 2 223 ? -47.878 -30.933 25.175  1    76.2   ? 393 ASP D CG  1 
ATOM   8498 O  OD1 . ASP D 2 223 ? -47.446 -32.021 25.594  1    81.02  ? 393 ASP D OD1 1 
ATOM   8499 O  OD2 . ASP D 2 223 ? -47.519 -30.404 24.108  1    79.03  ? 393 ASP D OD2 1 
ATOM   8500 N  N   . LEU D 2 224 ? -51.4   -29.412 27.876  1    74.93  ? 394 LEU D N   1 
ATOM   8501 C  CA  . LEU D 2 224 ? -51.815 -28.78  29.117  1    73.49  ? 394 LEU D CA  1 
ATOM   8502 C  C   . LEU D 2 224 ? -52.808 -29.662 29.859  1    77.69  ? 394 LEU D C   1 
ATOM   8503 O  O   . LEU D 2 224 ? -52.771 -29.755 31.089  1    74.04  ? 394 LEU D O   1 
ATOM   8504 C  CB  . LEU D 2 224 ? -52.385 -27.397 28.837  1    73.06  ? 394 LEU D CB  1 
ATOM   8505 C  CG  . LEU D 2 224 ? -52.507 -26.482 30.061  1    71.34  ? 394 LEU D CG  1 
ATOM   8506 C  CD1 . LEU D 2 224 ? -51.166 -26.258 30.747  1    65.14  ? 394 LEU D CD1 1 
ATOM   8507 C  CD2 . LEU D 2 224 ? -53.119 -25.152 29.643  1    68.94  ? 394 LEU D CD2 1 
ATOM   8508 N  N   . HIS D 2 225 ? -53.678 -30.33  29.088  1    83.58  ? 395 HIS D N   1 
ATOM   8509 C  CA  . HIS D 2 225 ? -54.577 -31.324 29.646  1    86.83  ? 395 HIS D CA  1 
ATOM   8510 C  C   . HIS D 2 225 ? -53.772 -32.371 30.411  1    88.15  ? 395 HIS D C   1 
ATOM   8511 O  O   . HIS D 2 225 ? -54.105 -32.673 31.553  1    92.5   ? 395 HIS D O   1 
ATOM   8512 C  CB  . HIS D 2 225 ? -55.441 -31.967 28.557  1    96.78  ? 395 HIS D CB  1 
ATOM   8513 C  CG  . HIS D 2 225 ? -56.467 -32.939 29.07   1    100.05 ? 395 HIS D CG  1 
ATOM   8514 N  ND1 . HIS D 2 225 ? -57.343 -32.63  30.092  1    100.56 ? 395 HIS D ND1 1 
ATOM   8515 C  CD2 . HIS D 2 225 ? -56.76  -34.194 28.704  1    98.54  ? 395 HIS D CD2 1 
ATOM   8516 C  CE1 . HIS D 2 225 ? -58.13  -33.663 30.336  1    100.33 ? 395 HIS D CE1 1 
ATOM   8517 N  NE2 . HIS D 2 225 ? -57.805 -34.619 29.494  1    102.27 ? 395 HIS D NE2 1 
ATOM   8518 N  N   . GLN D 2 226 ? -52.714 -32.912 29.794  1    87.99  ? 396 GLN D N   1 
ATOM   8519 C  CA  . GLN D 2 226 ? -51.944 -33.99  30.407  1    91.2   ? 396 GLN D CA  1 
ATOM   8520 C  C   . GLN D 2 226 ? -51.255 -33.47  31.669  1    86.36  ? 396 GLN D C   1 
ATOM   8521 O  O   . GLN D 2 226 ? -51.24  -34.15  32.692  1    87.21  ? 396 GLN D O   1 
ATOM   8522 C  CB  . GLN D 2 226 ? -50.857 -34.571 29.503  1    96.15  ? 396 GLN D CB  1 
ATOM   8523 C  CG  . GLN D 2 226 ? -51.178 -34.511 28.015  1    109.81 ? 396 GLN D CG  1 
ATOM   8524 C  CD  . GLN D 2 226 ? -49.985 -34.818 27.138  1    119.75 ? 396 GLN D CD  1 
ATOM   8525 O  OE1 . GLN D 2 226 ? -49.462 -33.95  26.421  1    131.39 ? 396 GLN D OE1 1 
ATOM   8526 N  NE2 . GLN D 2 226 ? -49.554 -36.072 27.19   1    114.75 ? 396 GLN D NE2 1 
ATOM   8527 N  N   . THR D 2 227 ? -50.712 -32.25  31.599  1    78.01  ? 397 THR D N   1 
ATOM   8528 C  CA  . THR D 2 227 ? -50.044 -31.649 32.746  1    76.13  ? 397 THR D CA  1 
ATOM   8529 C  C   . THR D 2 227 ? -51.019 -31.572 33.917  1    74.13  ? 397 THR D C   1 
ATOM   8530 O  O   . THR D 2 227 ? -50.641 -31.86  35.053  1    72.37  ? 397 THR D O   1 
ATOM   8531 C  CB  . THR D 2 227 ? -49.453 -30.272 32.41   1    72.64  ? 397 THR D CB  1 
ATOM   8532 O  OG1 . THR D 2 227 ? -48.386 -30.446 31.483  1    71.59  ? 397 THR D OG1 1 
ATOM   8533 C  CG2 . THR D 2 227 ? -48.873 -29.575 33.623  1    68.6   ? 397 THR D CG2 1 
ATOM   8534 N  N   . TYR D 2 228 ? -52.264 -31.192 33.634  1    74.33  ? 398 TYR D N   1 
ATOM   8535 C  CA  . TYR D 2 228 ? -53.295 -31.065 34.697  1    76.14  ? 398 TYR D CA  1 
ATOM   8536 C  C   . TYR D 2 228 ? -53.562 -32.432 35.278  1    82.44  ? 398 TYR D C   1 
ATOM   8537 O  O   . TYR D 2 228 ? -53.731 -32.557 36.502  1    90.55  ? 398 TYR D O   1 
ATOM   8538 C  CB  . TYR D 2 228 ? -54.549 -30.467 34.055  1    76.69  ? 398 TYR D CB  1 
ATOM   8539 C  CG  . TYR D 2 228 ? -55.691 -30.001 34.948  1    79.17  ? 398 TYR D CG  1 
ATOM   8540 C  CD1 . TYR D 2 228 ? -55.6   -30.037 36.333  1    79.31  ? 398 TYR D CD1 1 
ATOM   8541 C  CD2 . TYR D 2 228 ? -56.865 -29.509 34.391  1    79.59  ? 398 TYR D CD2 1 
ATOM   8542 C  CE1 . TYR D 2 228 ? -56.645 -29.612 37.135  1    79.17  ? 398 TYR D CE1 1 
ATOM   8543 C  CE2 . TYR D 2 228 ? -57.914 -29.073 35.182  1    80.37  ? 398 TYR D CE2 1 
ATOM   8544 C  CZ  . TYR D 2 228 ? -57.804 -29.128 36.559  1    79.56  ? 398 TYR D CZ  1 
ATOM   8545 O  OH  . TYR D 2 228 ? -58.834 -28.707 37.346  1    78.15  ? 398 TYR D OH  1 
ATOM   8546 N  N   . LEU D 2 229 ? -53.579 -33.453 34.426  1    84.29  ? 399 LEU D N   1 
ATOM   8547 C  CA  . LEU D 2 229 ? -53.933 -34.811 34.902  1    86.61  ? 399 LEU D CA  1 
ATOM   8548 C  C   . LEU D 2 229 ? -52.819 -35.372 35.788  1    85.87  ? 399 LEU D C   1 
ATOM   8549 O  O   . LEU D 2 229 ? -53.15  -36.003 36.805  1    85.46  ? 399 LEU D O   1 
ATOM   8550 C  CB  . LEU D 2 229 ? -54.195 -35.709 33.697  1    88     ? 399 LEU D CB  1 
ATOM   8551 C  CG  . LEU D 2 229 ? -55.396 -35.336 32.826  1    89     ? 399 LEU D CG  1 
ATOM   8552 C  CD1 . LEU D 2 229 ? -55.286 -36.039 31.49   1    91.54  ? 399 LEU D CD1 1 
ATOM   8553 C  CD2 . LEU D 2 229 ? -56.693 -35.704 33.513  1    91.25  ? 399 LEU D CD2 1 
ATOM   8554 N  N   . ARG D 2 230 ? -51.559 -35.156 35.42   1    84.04  ? 400 ARG D N   1 
ATOM   8555 C  CA  . ARG D 2 230 ? -50.446 -35.767 36.188  1    89.57  ? 400 ARG D CA  1 
ATOM   8556 C  C   . ARG D 2 230 ? -50.048 -34.864 37.358  1    85.04  ? 400 ARG D C   1 
ATOM   8557 O  O   . ARG D 2 230 ? -49.214 -35.295 38.175  1    81.38  ? 400 ARG D O   1 
ATOM   8558 C  CB  . ARG D 2 230 ? -49.26  -35.996 35.251  1    95.54  ? 400 ARG D CB  1 
ATOM   8559 C  CG  . ARG D 2 230 ? -49.38  -37.265 34.422  1    108.1  ? 400 ARG D CG  1 
ATOM   8560 C  CD  . ARG D 2 230 ? -49.315 -36.957 32.939  1    118.09 ? 400 ARG D CD  1 
ATOM   8561 N  NE  . ARG D 2 230 ? -50.634 -37.07  32.31   1    137.9  ? 400 ARG D NE  1 
ATOM   8562 C  CZ  . ARG D 2 230 ? -50.836 -37.561 31.097  1    139    ? 400 ARG D CZ  1 
ATOM   8563 N  NH1 . ARG D 2 230 ? -49.805 -37.858 30.327  1    136.36 ? 400 ARG D NH1 1 
ATOM   8564 N  NH2 . ARG D 2 230 ? -52.067 -37.742 30.652  1    132.86 ? 400 ARG D NH2 1 
ATOM   8565 N  N   . ALA D 2 231 ? -50.646 -33.679 37.445  1    79.68  ? 401 ALA D N   1 
ATOM   8566 C  CA  . ALA D 2 231 ? -50.27  -32.701 38.491  1    77.7   ? 401 ALA D CA  1 
ATOM   8567 C  C   . ALA D 2 231 ? -50.03  -33.366 39.848  1    80.7   ? 401 ALA D C   1 
ATOM   8568 O  O   . ALA D 2 231 ? -48.962 -33.102 40.423  1    90.05  ? 401 ALA D O   1 
ATOM   8569 C  CB  . ALA D 2 231 ? -51.311 -31.613 38.566  1    76.41  ? 401 ALA D CB  1 
ATOM   8570 N  N   . PRO D 2 232 ? -50.938 -34.186 40.422  1    81.44  ? 402 PRO D N   1 
ATOM   8571 C  CA  . PRO D 2 232 ? -50.699 -34.737 41.748  1    81.12  ? 402 PRO D CA  1 
ATOM   8572 C  C   . PRO D 2 232 ? -49.497 -35.662 41.876  1    81.41  ? 402 PRO D C   1 
ATOM   8573 O  O   . PRO D 2 232 ? -49.106 -35.982 43.007  1    81.22  ? 402 PRO D O   1 
ATOM   8574 C  CB  . PRO D 2 232 ? -52.015 -35.47  42      1    82.09  ? 402 PRO D CB  1 
ATOM   8575 C  CG  . PRO D 2 232 ? -53.017 -34.724 41.166  1    81.54  ? 402 PRO D CG  1 
ATOM   8576 C  CD  . PRO D 2 232 ? -52.238 -34.565 39.887  1    82.66  ? 402 PRO D CD  1 
ATOM   8577 N  N   . GLN D 2 233 ? -48.915 -36.077 40.754  1    84.34  ? 403 GLN D N   1 
ATOM   8578 C  CA  . GLN D 2 233 ? -47.767 -37.021 40.787  1    87.55  ? 403 GLN D CA  1 
ATOM   8579 C  C   . GLN D 2 233 ? -46.488 -36.294 40.359  1    82.3   ? 403 GLN D C   1 
ATOM   8580 O  O   . GLN D 2 233 ? -45.414 -36.917 40.421  1    81.79  ? 403 GLN D O   1 
ATOM   8581 C  CB  . GLN D 2 233 ? -48.046 -38.235 39.901  1    91.27  ? 403 GLN D CB  1 
ATOM   8582 C  CG  . GLN D 2 233 ? -49.16  -39.138 40.419  1    93.37  ? 403 GLN D CG  1 
ATOM   8583 C  CD  . GLN D 2 233 ? -50.51  -38.817 39.818  1    95.61  ? 403 GLN D CD  1 
ATOM   8584 O  OE1 . GLN D 2 233 ? -51.516 -38.698 40.524  1    101.5  ? 403 GLN D OE1 1 
ATOM   8585 N  NE2 . GLN D 2 233 ? -50.542 -38.669 38.502  1    93.62  ? 403 GLN D NE2 1 
ATOM   8586 N  N   . HIS D 2 234 ? -46.606 -35.036 39.94   1    78.37  ? 404 HIS D N   1 
ATOM   8587 C  CA  . HIS D 2 234 ? -45.454 -34.231 39.569  1    75.2   ? 404 HIS D CA  1 
ATOM   8588 C  C   . HIS D 2 234 ? -44.545 -34.045 40.785  1    72.42  ? 404 HIS D C   1 
ATOM   8589 O  O   . HIS D 2 234 ? -45.027 -33.803 41.892  1    74.91  ? 404 HIS D O   1 
ATOM   8590 C  CB  . HIS D 2 234 ? -45.911 -32.896 38.976  1    76.95  ? 404 HIS D CB  1 
ATOM   8591 C  CG  . HIS D 2 234 ? -44.857 -32.21  38.158  1    79.18  ? 404 HIS D CG  1 
ATOM   8592 N  ND1 . HIS D 2 234 ? -43.553 -32.015 38.563  1    76.13  ? 404 HIS D ND1 1 
ATOM   8593 C  CD2 . HIS D 2 234 ? -44.945 -31.656 36.946  1    79.65  ? 404 HIS D CD2 1 
ATOM   8594 C  CE1 . HIS D 2 234 ? -42.888 -31.362 37.625  1    74.32  ? 404 HIS D CE1 1 
ATOM   8595 N  NE2 . HIS D 2 234 ? -43.713 -31.142 36.627  1    76.49  ? 404 HIS D NE2 1 
ATOM   8596 N  N   . ALA D 2 235 ? -43.23  -34.15  40.565  1    67.01  ? 405 ALA D N   1 
ATOM   8597 C  CA  . ALA D 2 235 ? -42.232 -33.988 41.61   1    65.33  ? 405 ALA D CA  1 
ATOM   8598 C  C   . ALA D 2 235 ? -42.401 -32.634 42.291  1    66.92  ? 405 ALA D C   1 
ATOM   8599 O  O   . ALA D 2 235 ? -42.019 -32.483 43.443  1    67.2   ? 405 ALA D O   1 
ATOM   8600 C  CB  . ALA D 2 235 ? -40.844 -34.135 41.028  1    60.96  ? 405 ALA D CB  1 
ATOM   8601 N  N   . GLN D 2 236 ? -42.979 -31.668 41.563  1    68.85  ? 406 GLN D N   1 
ATOM   8602 C  CA  . GLN D 2 236 ? -43.167 -30.301 42.024  1    70.59  ? 406 GLN D CA  1 
ATOM   8603 C  C   . GLN D 2 236 ? -44.635 -30.055 42.376  1    73.54  ? 406 GLN D C   1 
ATOM   8604 O  O   . GLN D 2 236 ? -45.534 -30.253 41.546  1    79.84  ? 406 GLN D O   1 
ATOM   8605 C  CB  . GLN D 2 236 ? -42.645 -29.318 40.977  1    69.79  ? 406 GLN D CB  1 
ATOM   8606 C  CG  . GLN D 2 236 ? -41.174 -28.96  41.138  1    69.59  ? 406 GLN D CG  1 
ATOM   8607 C  CD  . GLN D 2 236 ? -40.229 -30.129 40.981  1    79.2   ? 406 GLN D CD  1 
ATOM   8608 O  OE1 . GLN D 2 236 ? -40.216 -30.811 39.944  1    86.34  ? 406 GLN D OE1 1 
ATOM   8609 N  NE2 . GLN D 2 236 ? -39.428 -30.356 42.016  1    74.95  ? 406 GLN D NE2 1 
ATOM   8610 N  N   . GLN D 2 237 ? -44.837 -29.58  43.614  1    70.69  ? 407 GLN D N   1 
ATOM   8611 C  CA  . GLN D 2 237 ? -46.13  -29.547 44.274  1    72.16  ? 407 GLN D CA  1 
ATOM   8612 C  C   . GLN D 2 237 ? -46.487 -28.158 44.81   1    73.11  ? 407 GLN D C   1 
ATOM   8613 O  O   . GLN D 2 237 ? -47.625 -27.99  45.231  1    77.06  ? 407 GLN D O   1 
ATOM   8614 C  CB  . GLN D 2 237 ? -46.157 -30.541 45.436  1    71.97  ? 407 GLN D CB  1 
ATOM   8615 C  CG  . GLN D 2 237 ? -46.332 -32.001 45.022  1    75.1   ? 407 GLN D CG  1 
ATOM   8616 C  CD  . GLN D 2 237 ? -47.454 -32.225 44.028  1    75.59  ? 407 GLN D CD  1 
ATOM   8617 O  OE1 . GLN D 2 237 ? -48.591 -31.783 44.223  1    77.22  ? 407 GLN D OE1 1 
ATOM   8618 N  NE2 . GLN D 2 237 ? -47.136 -32.882 42.925  1    76.35  ? 407 GLN D NE2 1 
ATOM   8619 N  N   . SER D 2 238 ? -45.561 -27.18  44.8    1    66.09  ? 408 SER D N   1 
ATOM   8620 C  CA  . SER D 2 238 ? -45.818 -25.876 45.413  1    65.97  ? 408 SER D CA  1 
ATOM   8621 C  C   . SER D 2 238 ? -47.037 -25.161 44.829  1    65.27  ? 408 SER D C   1 
ATOM   8622 O  O   . SER D 2 238 ? -47.782 -24.503 45.559  1    64.28  ? 408 SER D O   1 
ATOM   8623 C  CB  . SER D 2 238 ? -44.631 -24.973 45.372  1    61.87  ? 408 SER D CB  1 
ATOM   8624 O  OG  . SER D 2 238 ? -43.581 -25.541 46.131  1    69.02  ? 408 SER D OG  1 
ATOM   8625 N  N   . ILE D 2 239 ? -47.231 -25.286 43.514  1    64.43  ? 409 ILE D N   1 
ATOM   8626 C  CA  . ILE D 2 239 ? -48.343 -24.618 42.855  1    65.2   ? 409 ILE D CA  1 
ATOM   8627 C  C   . ILE D 2 239 ? -49.668 -25.237 43.303  1    68.53  ? 409 ILE D C   1 
ATOM   8628 O  O   . ILE D 2 239 ? -50.642 -24.516 43.511  1    73.08  ? 409 ILE D O   1 
ATOM   8629 C  CB  . ILE D 2 239 ? -48.178 -24.629 41.326  1    62.12  ? 409 ILE D CB  1 
ATOM   8630 C  CG1 . ILE D 2 239 ? -46.887 -23.927 40.915  1    59.5   ? 409 ILE D CG1 1 
ATOM   8631 C  CG2 . ILE D 2 239 ? -49.381 -23.984 40.649  1    58.73  ? 409 ILE D CG2 1 
ATOM   8632 C  CD1 . ILE D 2 239 ? -46.531 -24.084 39.449  1    56.55  ? 409 ILE D CD1 1 
ATOM   8633 N  N   . ARG D 2 240 ? -49.72  -26.565 43.436  1    68.76  ? 410 ARG D N   1 
ATOM   8634 C  CA  . ARG D 2 240 ? -50.929 -27.231 43.906  1    74.32  ? 410 ARG D CA  1 
ATOM   8635 C  C   . ARG D 2 240 ? -51.259 -26.775 45.328  1    75.74  ? 410 ARG D C   1 
ATOM   8636 O  O   . ARG D 2 240 ? -52.374 -26.329 45.585  1    79.32  ? 410 ARG D O   1 
ATOM   8637 C  CB  . ARG D 2 240 ? -50.858 -28.76  43.77   1    77.08  ? 410 ARG D CB  1 
ATOM   8638 C  CG  . ARG D 2 240 ? -51.068 -29.317 42.367  1    74.81  ? 410 ARG D CG  1 
ATOM   8639 C  CD  . ARG D 2 240 ? -51.136 -30.841 42.299  1    75.57  ? 410 ARG D CD  1 
ATOM   8640 N  NE  . ARG D 2 240 ? -52.418 -31.384 42.757  1    78.07  ? 410 ARG D NE  1 
ATOM   8641 C  CZ  . ARG D 2 240 ? -52.587 -32.101 43.861  1    79.24  ? 410 ARG D CZ  1 
ATOM   8642 N  NH1 . ARG D 2 240 ? -53.791 -32.481 44.23   1    78.68  ? 410 ARG D NH1 1 
ATOM   8643 N  NH2 . ARG D 2 240 ? -51.555 -32.408 44.621  1    80.11  ? 410 ARG D NH2 1 
ATOM   8644 N  N   . GLU D 2 241 ? -50.275 -26.866 46.233  1    74.16  ? 411 GLU D N   1 
ATOM   8645 C  CA  . GLU D 2 241 ? -50.392 -26.364 47.596  1    78.18  ? 411 GLU D CA  1 
ATOM   8646 C  C   . GLU D 2 241 ? -51.019 -24.967 47.602  1    76.85  ? 411 GLU D C   1 
ATOM   8647 O  O   . GLU D 2 241 ? -51.936 -24.707 48.375  1    73.13  ? 411 GLU D O   1 
ATOM   8648 C  CB  . GLU D 2 241 ? -49.032 -26.16  48.28   1    83.74  ? 411 GLU D CB  1 
ATOM   8649 C  CG  . GLU D 2 241 ? -48.135 -27.391 48.398  1    87.24  ? 411 GLU D CG  1 
ATOM   8650 C  CD  . GLU D 2 241 ? -48.776 -28.608 49.035  1    101.4  ? 411 GLU D CD  1 
ATOM   8651 O  OE1 . GLU D 2 241 ? -49.971 -28.603 49.476  1    103.44 ? 411 GLU D OE1 1 
ATOM   8652 O  OE2 . GLU D 2 241 ? -48.016 -29.609 49.055  1    111.71 ? 411 GLU D OE2 1 
ATOM   8653 N  N   . LYS D 2 242 ? -50.459 -24.073 46.766  1    77.77  ? 412 LYS D N   1 
ATOM   8654 C  CA  . LYS D 2 242 ? -50.778 -22.652 46.713  1    76.15  ? 412 LYS D CA  1 
ATOM   8655 C  C   . LYS D 2 242 ? -52.253 -22.45  46.387  1    77.06  ? 412 LYS D C   1 
ATOM   8656 O  O   . LYS D 2 242 ? -52.937 -21.714 47.093  1    79.75  ? 412 LYS D O   1 
ATOM   8657 C  CB  . LYS D 2 242 ? -49.872 -21.966 45.682  1    71.8   ? 412 LYS D CB  1 
ATOM   8658 C  CG  . LYS D 2 242 ? -50.275 -20.568 45.228  1    66.58  ? 412 LYS D CG  1 
ATOM   8659 C  CD  . LYS D 2 242 ? -49.271 -19.973 44.252  1    61.91  ? 412 LYS D CD  1 
ATOM   8660 C  CE  . LYS D 2 242 ? -49.617 -18.619 43.689  1    57.11  ? 412 LYS D CE  1 
ATOM   8661 N  NZ  . LYS D 2 242 ? -48.723 -18.186 42.611  1    51.11  ? 412 LYS D NZ  1 
ATOM   8662 N  N   . TYR D 2 243 ? -52.732 -23.146 45.343  1    77.62  ? 413 TYR D N   1 
ATOM   8663 C  CA  . TYR D 2 243 ? -54.082 -22.961 44.821  1    76.42  ? 413 TYR D CA  1 
ATOM   8664 C  C   . TYR D 2 243 ? -55.108 -23.854 45.538  1    82.27  ? 413 TYR D C   1 
ATOM   8665 O  O   . TYR D 2 243 ? -56.247 -23.958 45.082  1    83.12  ? 413 TYR D O   1 
ATOM   8666 C  CB  . TYR D 2 243 ? -54.043 -23.174 43.303  1    71.75  ? 413 TYR D CB  1 
ATOM   8667 C  CG  . TYR D 2 243 ? -53.555 -21.983 42.5    1    71.04  ? 413 TYR D CG  1 
ATOM   8668 C  CD1 . TYR D 2 243 ? -52.192 -21.771 42.261  1    72.53  ? 413 TYR D CD1 1 
ATOM   8669 C  CD2 . TYR D 2 243 ? -54.455 -21.05  42      1    69.6   ? 413 TYR D CD2 1 
ATOM   8670 C  CE1 . TYR D 2 243 ? -51.748 -20.673 41.532  1    66.02  ? 413 TYR D CE1 1 
ATOM   8671 C  CE2 . TYR D 2 243 ? -54.025 -19.95  41.275  1    66.93  ? 413 TYR D CE2 1 
ATOM   8672 C  CZ  . TYR D 2 243 ? -52.674 -19.764 41.04   1    64.64  ? 413 TYR D CZ  1 
ATOM   8673 O  OH  . TYR D 2 243 ? -52.323 -18.675 40.321  1    59.84  ? 413 TYR D OH  1 
ATOM   8674 N  N   . LYS D 2 244 ? -54.722 -24.507 46.646  1    84.66  ? 414 LYS D N   1 
ATOM   8675 C  CA  . LYS D 2 244 ? -55.666 -25.132 47.567  1    86.94  ? 414 LYS D CA  1 
ATOM   8676 C  C   . LYS D 2 244 ? -56.272 -24.075 48.485  1    90.9   ? 414 LYS D C   1 
ATOM   8677 O  O   . LYS D 2 244 ? -57.399 -24.239 48.953  1    98.62  ? 414 LYS D O   1 
ATOM   8678 C  CB  . LYS D 2 244 ? -55.032 -26.178 48.49   1    88.4   ? 414 LYS D CB  1 
ATOM   8679 C  CG  . LYS D 2 244 ? -54.816 -27.559 47.891  1    96.8   ? 414 LYS D CG  1 
ATOM   8680 C  CD  . LYS D 2 244 ? -53.963 -28.529 48.711  1    96.45  ? 414 LYS D CD  1 
ATOM   8681 C  CE  . LYS D 2 244 ? -53.69  -29.806 47.966  1    94.68  ? 414 LYS D CE  1 
ATOM   8682 N  NZ  . LYS D 2 244 ? -52.833 -30.697 48.748  1    95.91  ? 414 LYS D NZ  1 
ATOM   8683 N  N   . ASN D 2 245 ? -55.506 -23.005 48.746  1    89.81  ? 415 ASN D N   1 
ATOM   8684 C  CA  . ASN D 2 245 ? -55.926 -21.906 49.6    1    94.24  ? 415 ASN D CA  1 
ATOM   8685 C  C   . ASN D 2 245 ? -57.225 -21.292 49.066  1    93.23  ? 415 ASN D C   1 
ATOM   8686 O  O   . ASN D 2 245 ? -57.51  -21.381 47.87   1    91.14  ? 415 ASN D O   1 
ATOM   8687 C  CB  . ASN D 2 245 ? -54.785 -20.907 49.775  1    98.88  ? 415 ASN D CB  1 
ATOM   8688 C  CG  . ASN D 2 245 ? -55.086 -19.886 50.852  1    115.85 ? 415 ASN D CG  1 
ATOM   8689 O  OD1 . ASN D 2 245 ? -55.727 -18.855 50.6    1    118.11 ? 415 ASN D OD1 1 
ATOM   8690 N  ND2 . ASN D 2 245 ? -54.635 -20.16  52.067  1    127.03 ? 415 ASN D ND2 1 
ATOM   8691 N  N   . SER D 2 246 ? -57.986 -20.642 49.965  1    90.83  ? 416 SER D N   1 
ATOM   8692 C  CA  . SER D 2 246 ? -59.236 -19.96  49.646  1    92.24  ? 416 SER D CA  1 
ATOM   8693 C  C   . SER D 2 246 ? -59.039 -18.753 48.716  1    89.2   ? 416 SER D C   1 
ATOM   8694 O  O   . SER D 2 246 ? -59.899 -18.473 47.88   1    88.52  ? 416 SER D O   1 
ATOM   8695 C  CB  . SER D 2 246 ? -59.951 -19.588 50.908  1    91.93  ? 416 SER D CB  1 
ATOM   8696 O  OG  . SER D 2 246 ? -58.99  -19.197 51.882  1    94.74  ? 416 SER D OG  1 
ATOM   8697 N  N   . LYS D 2 247 ? -57.913 -18.039 48.875  1    86.45  ? 417 LYS D N   1 
ATOM   8698 C  CA  . LYS D 2 247 ? -57.502 -16.965 47.982  1    85.64  ? 417 LYS D CA  1 
ATOM   8699 C  C   . LYS D 2 247 ? -57.738 -17.344 46.518  1    86.32  ? 417 LYS D C   1 
ATOM   8700 O  O   . LYS D 2 247 ? -58.175 -16.507 45.731  1    87.94  ? 417 LYS D O   1 
ATOM   8701 C  CB  . LYS D 2 247 ? -56.027 -16.628 48.219  1    85.79  ? 417 LYS D CB  1 
ATOM   8702 C  CG  . LYS D 2 247 ? -55.444 -15.54  47.328  1    87.28  ? 417 LYS D CG  1 
ATOM   8703 C  CD  . LYS D 2 247 ? -53.999 -15.214 47.69   1    95.11  ? 417 LYS D CD  1 
ATOM   8704 C  CE  . LYS D 2 247 ? -53.596 -13.8   47.354  1    99.17  ? 417 LYS D CE  1 
ATOM   8705 N  NZ  . LYS D 2 247 ? -53.316 -13.637 45.924  1    114.67 ? 417 LYS D NZ  1 
ATOM   8706 N  N   . TYR D 2 248 ? -57.465 -18.608 46.168  1    84.94  ? 418 TYR D N   1 
ATOM   8707 C  CA  . TYR D 2 248 ? -57.623 -19.095 44.805  1    80.16  ? 418 TYR D CA  1 
ATOM   8708 C  C   . TYR D 2 248 ? -58.777 -20.096 44.739  1    81.76  ? 418 TYR D C   1 
ATOM   8709 O  O   . TYR D 2 248 ? -58.802 -20.933 43.839  1    82.01  ? 418 TYR D O   1 
ATOM   8710 C  CB  . TYR D 2 248 ? -56.299 -19.662 44.264  1    75.98  ? 418 TYR D CB  1 
ATOM   8711 C  CG  . TYR D 2 248 ? -55.09  -18.755 44.434  1    70.55  ? 418 TYR D CG  1 
ATOM   8712 C  CD1 . TYR D 2 248 ? -54.925 -17.633 43.623  1    68.9   ? 418 TYR D CD1 1 
ATOM   8713 C  CD2 . TYR D 2 248 ? -54.139 -18.996 45.428  1    67.89  ? 418 TYR D CD2 1 
ATOM   8714 C  CE1 . TYR D 2 248 ? -53.839 -16.778 43.783  1    64.95  ? 418 TYR D CE1 1 
ATOM   8715 C  CE2 . TYR D 2 248 ? -53.066 -18.137 45.61   1    68.82  ? 418 TYR D CE2 1 
ATOM   8716 C  CZ  . TYR D 2 248 ? -52.906 -17.026 44.781  1    70.66  ? 418 TYR D CZ  1 
ATOM   8717 O  OH  . TYR D 2 248 ? -51.818 -16.19  44.951  1    70.64  ? 418 TYR D OH  1 
ATOM   8718 N  N   . HIS D 2 249 ? -59.72  -20.016 45.693  1    85.38  ? 419 HIS D N   1 
ATOM   8719 C  CA  . HIS D 2 249 ? -60.968 -20.784 45.672  1    92.95  ? 419 HIS D CA  1 
ATOM   8720 C  C   . HIS D 2 249 ? -60.736 -22.297 45.59   1    93.83  ? 419 HIS D C   1 
ATOM   8721 O  O   . HIS D 2 249 ? -61.529 -22.995 44.965  1    99.32  ? 419 HIS D O   1 
ATOM   8722 C  CB  . HIS D 2 249 ? -61.88  -20.281 44.541  1    95.07  ? 419 HIS D CB  1 
ATOM   8723 C  CG  . HIS D 2 249 ? -61.984 -18.79  44.533  1    101.33 ? 419 HIS D CG  1 
ATOM   8724 N  ND1 . HIS D 2 249 ? -61.564 -17.983 43.494  1    99.36  ? 419 HIS D ND1 1 
ATOM   8725 C  CD2 . HIS D 2 249 ? -62.409 -17.959 45.502  1    104.9  ? 419 HIS D CD2 1 
ATOM   8726 C  CE1 . HIS D 2 249 ? -61.749 -16.71  43.829  1    100.11 ? 419 HIS D CE1 1 
ATOM   8727 N  NE2 . HIS D 2 249 ? -62.271 -16.675 45.043  1    102.79 ? 419 HIS D NE2 1 
ATOM   8728 N  N   . GLY D 2 250 ? -59.645 -22.796 46.19   1    91.78  ? 420 GLY D N   1 
ATOM   8729 C  CA  . GLY D 2 250 ? -59.254 -24.206 46.187  1    89.94  ? 420 GLY D CA  1 
ATOM   8730 C  C   . GLY D 2 250 ? -59.318 -24.935 44.835  1    90.47  ? 420 GLY D C   1 
ATOM   8731 O  O   . GLY D 2 250 ? -59.537 -26.149 44.821  1    93.2   ? 420 GLY D O   1 
ATOM   8732 N  N   . VAL D 2 251 ? -59.077 -24.23  43.713  1    87.56  ? 421 VAL D N   1 
ATOM   8733 C  CA  . VAL D 2 251 ? -59.331 -24.764 42.375  1    88.8   ? 421 VAL D CA  1 
ATOM   8734 C  C   . VAL D 2 251 ? -58.388 -25.915 42.017  1    88.81  ? 421 VAL D C   1 
ATOM   8735 O  O   . VAL D 2 251 ? -58.638 -26.622 41.037  1    93.27  ? 421 VAL D O   1 
ATOM   8736 C  CB  . VAL D 2 251 ? -59.258 -23.686 41.28   1    86.43  ? 421 VAL D CB  1 
ATOM   8737 C  CG1 . VAL D 2 251 ? -60.426 -22.706 41.37   1    88.28  ? 421 VAL D CG1 1 
ATOM   8738 C  CG2 . VAL D 2 251 ? -57.908 -22.974 41.3    1    81.63  ? 421 VAL D CG2 1 
ATOM   8739 N  N   . SER D 2 252 ? -57.285 -26.073 42.764  1    85.17  ? 422 SER D N   1 
ATOM   8740 C  CA  . SER D 2 252 ? -56.361 -27.174 42.53   1    82.91  ? 422 SER D CA  1 
ATOM   8741 C  C   . SER D 2 252 ? -56.986 -28.494 42.974  1    84.51  ? 422 SER D C   1 
ATOM   8742 O  O   . SER D 2 252 ? -56.58  -29.547 42.501  1    84.45  ? 422 SER D O   1 
ATOM   8743 C  CB  . SER D 2 252 ? -54.998 -26.955 43.163  1    79.17  ? 422 SER D CB  1 
ATOM   8744 O  OG  . SER D 2 252 ? -55.1   -26.601 44.534  1    80.52  ? 422 SER D OG  1 
ATOM   8745 N  N   . LEU D 2 253 ? -57.99  -28.417 43.854  1    86.03  ? 423 LEU D N   1 
ATOM   8746 C  CA  . LEU D 2 253 ? -58.679 -29.591 44.374  1    90.75  ? 423 LEU D CA  1 
ATOM   8747 C  C   . LEU D 2 253 ? -59.721 -30.125 43.393  1    91.11  ? 423 LEU D C   1 
ATOM   8748 O  O   . LEU D 2 253 ? -60.14  -31.272 43.516  1    92.25  ? 423 LEU D O   1 
ATOM   8749 C  CB  . LEU D 2 253 ? -59.312 -29.265 45.725  1    90.82  ? 423 LEU D CB  1 
ATOM   8750 C  CG  . LEU D 2 253 ? -58.326 -28.967 46.86   1    89.75  ? 423 LEU D CG  1 
ATOM   8751 C  CD1 . LEU D 2 253 ? -59.068 -28.434 48.076  1    89.12  ? 423 LEU D CD1 1 
ATOM   8752 C  CD2 . LEU D 2 253 ? -57.496 -30.198 47.215  1    88.59  ? 423 LEU D CD2 1 
ATOM   8753 N  N   . LEU D 2 254 ? -60.143 -29.297 42.434  1    90.07  ? 424 LEU D N   1 
ATOM   8754 C  CA  . LEU D 2 254 ? -61.11  -29.739 41.445  1    96.22  ? 424 LEU D CA  1 
ATOM   8755 C  C   . LEU D 2 254 ? -60.574 -30.96  40.707  1    98.8   ? 424 LEU D C   1 
ATOM   8756 O  O   . LEU D 2 254 ? -59.364 -31.108 40.554  1    100.62 ? 424 LEU D O   1 
ATOM   8757 C  CB  . LEU D 2 254 ? -61.45  -28.595 40.494  1    93.85  ? 424 LEU D CB  1 
ATOM   8758 C  CG  . LEU D 2 254 ? -62.104 -27.378 41.156  1    97.98  ? 424 LEU D CG  1 
ATOM   8759 C  CD1 . LEU D 2 254 ? -62.639 -26.421 40.103  1    98.1   ? 424 LEU D CD1 1 
ATOM   8760 C  CD2 . LEU D 2 254 ? -63.236 -27.818 42.095  1    97.15  ? 424 LEU D CD2 1 
ATOM   8761 N  N   . ASN D 2 255 ? -61.49  -31.836 40.279  1    103.99 ? 425 ASN D N   1 
ATOM   8762 C  CA  . ASN D 2 255 ? -61.147 -32.939 39.4    1    105.96 ? 425 ASN D CA  1 
ATOM   8763 C  C   . ASN D 2 255 ? -61.032 -32.396 37.98   1    103.84 ? 425 ASN D C   1 
ATOM   8764 O  O   . ASN D 2 255 ? -61.972 -31.774 37.498  1    108.49 ? 425 ASN D O   1 
ATOM   8765 C  CB  . ASN D 2 255 ? -62.2   -34.042 39.456  1    111.77 ? 425 ASN D CB  1 
ATOM   8766 C  CG  . ASN D 2 255 ? -62.197 -34.784 40.771  1    116.3  ? 425 ASN D CG  1 
ATOM   8767 O  OD1 . ASN D 2 255 ? -63.133 -34.648 41.565  1    118.69 ? 425 ASN D OD1 1 
ATOM   8768 N  ND2 . ASN D 2 255 ? -61.16  -35.571 41.015  1    118.55 ? 425 ASN D ND2 1 
ATOM   8769 N  N   . PRO D 2 256 ? -59.906 -32.627 37.261  1    98.46  ? 426 PRO D N   1 
ATOM   8770 C  CA  . PRO D 2 256 ? -59.826 -32.226 35.869  1    96.5   ? 426 PRO D CA  1 
ATOM   8771 C  C   . PRO D 2 256 ? -60.797 -33.001 35.02   1    100.86 ? 426 PRO D C   1 
ATOM   8772 O  O   . PRO D 2 256 ? -61.297 -34.057 35.441  1    101.4  ? 426 PRO D O   1 
ATOM   8773 C  CB  . PRO D 2 256 ? -58.383 -32.6   35.52   1    94.62  ? 426 PRO D CB  1 
ATOM   8774 C  CG  . PRO D 2 256 ? -58.056 -33.744 36.431  1    94.74  ? 426 PRO D CG  1 
ATOM   8775 C  CD  . PRO D 2 256 ? -58.632 -33.223 37.719  1    94.54  ? 426 PRO D CD  1 
ATOM   8776 N  N   . PRO D 2 257 ? -61.079 -32.55  33.786  1    99.74  ? 427 PRO D N   1 
ATOM   8777 C  CA  . PRO D 2 257 ? -61.904 -33.34  32.896  1    102.03 ? 427 PRO D CA  1 
ATOM   8778 C  C   . PRO D 2 257 ? -61.052 -34.538 32.518  1    106.46 ? 427 PRO D C   1 
ATOM   8779 O  O   . PRO D 2 257 ? -59.817 -34.466 32.616  1    105.69 ? 427 PRO D O   1 
ATOM   8780 C  CB  . PRO D 2 257 ? -62.164 -32.393 31.736  1    98.65  ? 427 PRO D CB  1 
ATOM   8781 C  CG  . PRO D 2 257 ? -60.997 -31.439 31.759  1    97.66  ? 427 PRO D CG  1 
ATOM   8782 C  CD  . PRO D 2 257 ? -60.614 -31.305 33.22   1    96.63  ? 427 PRO D CD  1 
ATOM   8783 N  N   . GLU D 2 258 ? -61.682 -35.619 32.053  1    113.57 ? 428 GLU D N   1 
ATOM   8784 C  CA  . GLU D 2 258 ? -60.898 -36.788 31.578  1    116.35 ? 428 GLU D CA  1 
ATOM   8785 C  C   . GLU D 2 258 ? -60.772 -36.707 30.054  1    114.22 ? 428 GLU D C   1 
ATOM   8786 O  O   . GLU D 2 258 ? -59.838 -37.324 29.507  1    106.8  ? 428 GLU D O   1 
ATOM   8787 C  CB  . GLU D 2 258 ? -61.55  -38.101 32.003  1    119.97 ? 428 GLU D CB  1 
ATOM   8788 C  CG  . GLU D 2 258 ? -62.424 -37.973 33.246  1    123.45 ? 428 GLU D CG  1 
ATOM   8789 C  CD  . GLU D 2 258 ? -63.12  -39.275 33.591  1    134.57 ? 428 GLU D CD  1 
ATOM   8790 O  OE1 . GLU D 2 258 ? -62.819 -40.29  32.93   1    137.08 ? 428 GLU D OE1 1 
ATOM   8791 O  OE2 . GLU D 2 258 ? -63.96  -39.277 34.514  1    141.26 ? 428 GLU D OE2 1 
ATOM   8792 N  N   . THR D 2 259 ? -61.675 -35.969 29.409  1    114.81 ? 429 THR D N   1 
ATOM   8793 C  CA  . THR D 2 259 ? -61.61  -35.787 27.948  1    112    ? 429 THR D CA  1 
ATOM   8794 C  C   . THR D 2 259 ? -62.026 -34.375 27.634  1    108.75 ? 429 THR D C   1 
ATOM   8795 O  O   . THR D 2 259 ? -62.637 -33.736 28.508  1    107.67 ? 429 THR D O   1 
ATOM   8796 C  CB  . THR D 2 259 ? -62.512 -36.811 27.265  1    120.92 ? 429 THR D CB  1 
ATOM   8797 O  OG1 . THR D 2 259 ? -63.822 -36.58  27.772  1    122.54 ? 429 THR D OG1 1 
ATOM   8798 C  CG2 . THR D 2 259 ? -62.1   -38.24  27.567  1    120.53 ? 429 THR D CG2 1 
ATOM   8799 N  N   . LEU D 2 260 ? -61.732 -33.904 26.423  1    111.15 ? 430 LEU D N   1 
ATOM   8800 C  CA  . LEU D 2 260 ? -62.007 -32.486 26.085  1    118.85 ? 430 LEU D CA  1 
ATOM   8801 C  C   . LEU D 2 260 ? -62.939 -32.386 24.875  1    127.27 ? 430 LEU D C   1 
ATOM   8802 O  O   . LEU D 2 260 ? -63.142 -31.253 24.395  1    129.84 ? 430 LEU D O   1 
ATOM   8803 C  CB  . LEU D 2 260 ? -60.688 -31.774 25.805  1    118.13 ? 430 LEU D CB  1 
ATOM   8804 C  CG  . LEU D 2 260 ? -59.55  -32.026 26.797  1    114.72 ? 430 LEU D CG  1 
ATOM   8805 C  CD1 . LEU D 2 260 ? -58.249 -31.523 26.199  1    106.22 ? 430 LEU D CD1 1 
ATOM   8806 C  CD2 . LEU D 2 260 ? -59.849 -31.318 28.103  1    118.13 ? 430 LEU D CD2 1 
ATOM   8807 N  N   . ASN D 2 261 ? -63.449 -33.513 24.384  1    136.59 ? 431 ASN D N   1 
ATOM   8808 C  CA  . ASN D 2 261 ? -64.444 -33.455 23.283  1    139.76 ? 431 ASN D CA  1 
ATOM   8809 C  C   . ASN D 2 261 ? -63.906 -32.565 22.165  1    135.11 ? 431 ASN D C   1 
ATOM   8810 O  O   . ASN D 2 261 ? -64.556 -31.553 21.841  1    135.83 ? 431 ASN D O   1 
ATOM   8811 C  CB  . ASN D 2 261 ? -65.788 -32.969 23.804  1    146.61 ? 431 ASN D CB  1 
ATOM   8812 C  CG  . ASN D 2 261 ? -66.235 -33.771 25.002  1    151.28 ? 431 ASN D CG  1 
ATOM   8813 O  OD1 . ASN D 2 261 ? -65.655 -34.821 25.301  1    152.6  ? 431 ASN D OD1 1 
ATOM   8814 N  ND2 . ASN D 2 261 ? -67.251 -33.292 25.704  1    153.82 ? 431 ASN D ND2 1 
ATOM   8815 N  N   . VAL D 2 262 ? -62.774 -32.951 21.583  1    132.91 ? 432 VAL D N   1 
ATOM   8816 C  CA  . VAL D 2 262 ? -62.151 -32.14  20.501  1    126.37 ? 432 VAL D CA  1 
ATOM   8817 C  C   . VAL D 2 262 ? -62.867 -32.433 19.175  1    134.13 ? 432 VAL D C   1 
ATOM   8818 O  O   . VAL D 2 262 ? -62.888 -31.52  18.321  1    136.63 ? 432 VAL D O   1 
ATOM   8819 C  CB  . VAL D 2 262 ? -60.653 -32.479 20.431  1    116.88 ? 432 VAL D CB  1 
ATOM   8820 C  CG1 . VAL D 2 262 ? -60.425 -33.984 20.357  1    111.9  ? 432 VAL D CG1 1 
ATOM   8821 C  CG2 . VAL D 2 262 ? -59.965 -31.778 19.265  1    112.62 ? 432 VAL D CG2 1 
HETATM 8822 C  C4  . HHT E 3 .   ? -9.03   -22.007 23.532  1    53.09  ? 601 HHT A C4  1 
HETATM 8823 C  C5  . HHT E 3 .   ? -10.181 -21.387 23.128  1    52.43  ? 601 HHT A C5  1 
HETATM 8824 C  C6  . HHT E 3 .   ? -10.046 -20.323 22.226  1    52.64  ? 601 HHT A C6  1 
HETATM 8825 C  C7  . HHT E 3 .   ? -8.812  -19.878 21.77   1    51.65  ? 601 HHT A C7  1 
HETATM 8826 C  C8  . HHT E 3 .   ? -8.688  -18.71  20.841  1    55.54  ? 601 HHT A C8  1 
HETATM 8827 C  C9  . HHT E 3 .   ? -8.526  -19.081 19.372  1    57.38  ? 601 HHT A C9  1 
HETATM 8828 C  C3  . HHT E 3 .   ? -7.766  -21.619 23.108  1    51.23  ? 601 HHT A C3  1 
HETATM 8829 C  C1  . HHT E 3 .   ? -5.247  -20.676 22.307  1    53.62  ? 601 HHT A C1  1 
HETATM 8830 O  O1  . HHT E 3 .   ? -6.437  -20.089 21.769  1    58.39  ? 601 HHT A O1  1 
HETATM 8831 C  C2  . HHT E 3 .   ? -7.65   -20.563 22.226  1    54.83  ? 601 HHT A C2  1 
HETATM 8832 BR BR1 . HHT E 3 .   ? -9.134  -23.448 24.731  1    59.37  ? 601 HHT A BR1 1 
HETATM 8833 O  O2  . HHT E 3 .   ? -8.972  -20.167 18.993  1    56.64  ? 601 HHT A O2  1 
HETATM 8834 O  O3  . HHT E 3 .   ? -7.992  -18.268 18.611  1    66.02  ? 601 HHT A O3  1 
HETATM 8835 C  C4  . HHT F 3 .   ? -6.148  -11.424 30.147  1    87.41  ? 602 HHT A C4  1 
HETATM 8836 C  C5  . HHT F 3 .   ? -7.186  -10.921 30.908  1    83.28  ? 602 HHT A C5  1 
HETATM 8837 C  C6  . HHT F 3 .   ? -6.933  -9.893  31.813  1    83.43  ? 602 HHT A C6  1 
HETATM 8838 C  C7  . HHT F 3 .   ? -5.648  -9.399  32.012  1    96.21  ? 602 HHT A C7  1 
HETATM 8839 C  C8  . HHT F 3 .   ? -5.359  -8.27   32.955  1    87.01  ? 602 HHT A C8  1 
HETATM 8840 C  C9  . HHT F 3 .   ? -4.843  -7.081  32.143  1    100.22 ? 602 HHT A C9  1 
HETATM 8841 C  C3  . HHT F 3 .   ? -4.858  -10.937 30.287  1    101.33 ? 602 HHT A C3  1 
HETATM 8842 C  C1  . HHT F 3 .   ? -2.181  -9.732  30.687  1    114.26 ? 602 HHT A C1  1 
HETATM 8843 O  O1  . HHT F 3 .   ? -3.352  -9.375  31.426  1    114.27 ? 602 HHT A O1  1 
HETATM 8844 C  C2  . HHT F 3 .   ? -4.604  -9.929  31.207  1    104.08 ? 602 HHT A C2  1 
HETATM 8845 BR BR1 . HHT F 3 .   ? -6.461  -12.805 28.857  1    71.25  ? 602 HHT A BR1 1 
HETATM 8846 O  O2  . HHT F 3 .   ? -3.648  -6.763  32.297  1    129.25 ? 602 HHT A O2  1 
HETATM 8847 O  O3  . HHT F 3 .   ? -5.597  -6.517  31.316  1    82.11  ? 602 HHT A O3  1 
HETATM 8848 C  C4  . HHT G 3 .   ? -7.194  -12.279 34.197  1    128.42 ? 603 HHT A C4  1 
HETATM 8849 C  C5  . HHT G 3 .   ? -7.761  -11.32  35.025  1    131.71 ? 603 HHT A C5  1 
HETATM 8850 C  C6  . HHT G 3 .   ? -6.939  -10.388 35.644  1    120.6  ? 603 HHT A C6  1 
HETATM 8851 C  C7  . HHT G 3 .   ? -5.57   -10.41  35.443  1    122.92 ? 603 HHT A C7  1 
HETATM 8852 C  C8  . HHT G 3 .   ? -4.658  -9.411  36.092  1    128.7  ? 603 HHT A C8  1 
HETATM 8853 C  C9  . HHT G 3 .   ? -3.451  -10.015 36.807  1    125.57 ? 603 HHT A C9  1 
HETATM 8854 C  C3  . HHT G 3 .   ? -5.831  -12.323 33.935  1    99.79  ? 603 HHT A C3  1 
HETATM 8855 C  C1  . HHT G 3 .   ? -3.124  -11.677 33.234  1    92.74  ? 603 HHT A C1  1 
HETATM 8856 O  O1  . HHT G 3 .   ? -3.675  -11.333 34.463  1    108.85 ? 603 HHT A O1  1 
HETATM 8857 C  C2  . HHT G 3 .   ? -5.02   -11.436 34.625  1    115.1  ? 603 HHT A C2  1 
HETATM 8858 BR BR1 . HHT G 3 .   ? -8.306  -13.585 33.389  1    103.64 ? 603 HHT A BR1 1 
HETATM 8859 O  O2  . HHT G 3 .   ? -3.608  -10.455 37.982  1    112.47 ? 603 HHT A O2  1 
HETATM 8860 O  O3  . HHT G 3 .   ? -2.362  -10.037 36.173  1    104.6  ? 603 HHT A O3  1 
HETATM 8861 C  C4  A HHT H 3 .   ? -19.87  -6.251  20.272  0.5  104.01 ? 604 HHT A C4  1 
HETATM 8862 C  C4  B HHT H 3 .   ? -19.946 -10.513 20.624  0.5  78.15  ? 604 HHT A C4  1 
HETATM 8863 C  C5  A HHT H 3 .   ? -21.204 -6.437  20.569  0.5  113.64 ? 604 HHT A C5  1 
HETATM 8864 C  C5  B HHT H 3 .   ? -18.983 -9.857  19.911  0.5  88.8   ? 604 HHT A C5  1 
HETATM 8865 C  C6  A HHT H 3 .   ? -21.927 -5.374  21.092  0.5  117.04 ? 604 HHT A C6  1 
HETATM 8866 C  C6  B HHT H 3 .   ? -18.904 -8.482  20.023  0.5  112.07 ? 604 HHT A C6  1 
HETATM 8867 C  C7  A HHT H 3 .   ? -21.337 -4.14   21.327  0.5  109.27 ? 604 HHT A C7  1 
HETATM 8868 C  C7  B HHT H 3 .   ? -19.759 -7.764  20.843  0.5  127.62 ? 604 HHT A C7  1 
HETATM 8869 C  C8  A HHT H 3 .   ? -22.113 -2.98   21.876  0.5  93.47  ? 604 HHT A C8  1 
HETATM 8870 C  C8  B HHT H 3 .   ? -19.638 -6.27   20.963  0.5  155.07 ? 604 HHT A C8  1 
HETATM 8871 C  C9  A HHT H 3 .   ? -23.341 -2.791  20.994  0.5  85.81  ? 604 HHT A C9  1 
HETATM 8872 C  C9  B HHT H 3 .   ? -20.666 -5.54   21.827  0.5  188.88 ? 604 HHT A C9  1 
HETATM 8873 C  C3  A HHT H 3 .   ? -19.233 -5.041  20.483  0.5  93.05  ? 604 HHT A C3  1 
HETATM 8874 C  C3  B HHT H 3 .   ? -20.84  -9.87   21.452  0.5  74.81  ? 604 HHT A C3  1 
HETATM 8875 C  C1  A HHT H 3 .   ? -18.033 -2.657  21.068  0.5  98.46  ? 604 HHT A C1  1 
HETATM 8876 C  C1  B HHT H 3 .   ? -22.604 -8.646  22.89   0.5  102.16 ? 604 HHT A C1  1 
HETATM 8877 O  O1  A HHT H 3 .   ? -19.441 -2.753  21.256  0.5  103.09 ? 604 HHT A O1  1 
HETATM 8878 O  O1  B HHT H 3 .   ? -21.588 -7.796  22.363  0.5  106.9  ? 604 HHT A O1  1 
HETATM 8879 C  C2  A HHT H 3 .   ? -19.971 -3.986  20.993  0.5  103.58 ? 604 HHT A C2  1 
HETATM 8880 C  C2  B HHT H 3 .   ? -20.74  -8.5    21.575  0.5  102.16 ? 604 HHT A C2  1 
HETATM 8881 BR BR1 A HHT H 3 .   ? -18.864 -7.69   19.554  0.5  111.42 ? 604 HHT A BR1 1 
HETATM 8882 BR BR1 B HHT H 3 .   ? -20.073 -12.379 20.46   0.5  81.18  ? 604 HHT A BR1 1 
HETATM 8883 O  O2  A HHT H 3 .   ? -24.027 -3.806  20.715  0.5  62.28  ? 604 HHT A O2  1 
HETATM 8884 O  O2  B HHT H 3 .   ? -21.627 -6.202  22.29   0.5  203.65 ? 604 HHT A O2  1 
HETATM 8885 O  O3  A HHT H 3 .   ? -23.579 -1.638  20.568  0.5  87.38  ? 604 HHT A O3  1 
HETATM 8886 O  O3  B HHT H 3 .   ? -20.499 -4.315  22.03   0.5  201.91 ? 604 HHT A O3  1 
HETATM 8887 C  C4  A HHT I 3 .   ? -14.924 16.053  1.726   0.25 191.34 ? 501 HHT B C4  1 
HETATM 8888 C  C4  B HHT I 3 .   ? -18.268 16.763  3.833   0.25 85.76  ? 501 HHT B C4  1 
HETATM 8889 C  C4  C HHT I 3 .   ? -14.032 16.79   2.119   0.5  85.76  ? 501 HHT B C4  1 
HETATM 8890 C  C5  A HHT I 3 .   ? -13.748 15.409  1.432   0.25 173.72 ? 501 HHT B C5  1 
HETATM 8891 C  C5  B HHT I 3 .   ? -19.198 17.007  2.852   0.25 100.59 ? 501 HHT B C5  1 
HETATM 8892 C  C5  C HHT I 3 .   ? -12.736 16.824  1.654   0.5  100.59 ? 501 HHT B C5  1 
HETATM 8893 C  C6  A HHT I 3 .   ? -12.806 16.041  0.645   0.25 150.41 ? 501 HHT B C6  1 
HETATM 8894 C  C6  B HHT I 3 .   ? -19.815 18.245  2.807   0.25 104.58 ? 501 HHT B C6  1 
HETATM 8895 C  C6  C HHT I 3 .   ? -11.957 17.94   1.896   0.5  104.58 ? 501 HHT B C6  1 
HETATM 8896 C  C7  A HHT I 3 .   ? -13.009 17.306  0.133   0.25 134.75 ? 501 HHT B C7  1 
HETATM 8897 C  C7  B HHT I 3 .   ? -19.523 19.239  3.724   0.25 97.76  ? 501 HHT B C7  1 
HETATM 8898 C  C7  C HHT I 3 .   ? -12.469 19.024  2.577   0.5  97.76  ? 501 HHT B C7  1 
HETATM 8899 C  C8  A HHT I 3 .   ? -11.949 17.957  -0.712  0.25 128.31 ? 501 HHT B C8  1 
HETATM 8900 C  C8  B HHT I 3 .   ? -20.189 20.582  3.68    0.25 91.46  ? 501 HHT B C8  1 
HETATM 8901 C  C8  C HHT I 3 .   ? -11.633 20.239  2.862   0.5  91.46  ? 501 HHT B C8  1 
HETATM 8902 C  C9  A HHT I 3 .   ? -10.632 17.185  -0.593  0.25 119.6  ? 501 HHT B C9  1 
HETATM 8903 C  C9  B HHT I 3 .   ? -19.299 21.688  3.124   0.25 91.46  ? 501 HHT B C9  1 
HETATM 8904 C  C9  C HHT I 3 .   ? -10.623 19.844  3.937   0.5  91.46  ? 501 HHT B C9  1 
HETATM 8905 C  C3  A HHT I 3 .   ? -15.201 17.322  1.249   0.25 153.64 ? 501 HHT B C3  1 
HETATM 8906 C  C3  B HHT I 3 .   ? -17.937 17.719  4.774   0.25 82.4   ? 501 HHT B C3  1 
HETATM 8907 C  C3  C HHT I 3 .   ? -14.612 17.84   2.807   0.5  82.4   ? 501 HHT B C3  1 
HETATM 8908 C  C1  A HHT I 3 .   ? -15.675 19.863  0.089   0.25 87.86  ? 501 HHT B C1  1 
HETATM 8909 C  C1  B HHT I 3 .   ? -16.963 20.17   6.003   0.25 79.96  ? 501 HHT B C1  1 
HETATM 8910 C  C1  C HHT I 3 .   ? -15.469 20.37   3.139   0.5  79.96  ? 501 HHT B C1  1 
HETATM 8911 O  O1  A HHT I 3 .   ? -14.416 19.214  -0.081  0.25 106.94 ? 501 HHT B O1  1 
HETATM 8912 O  O1  B HHT I 3 .   ? -18.312 19.968  5.6     0.25 92.01  ? 501 HHT B O1  1 
HETATM 8913 O  O1  C HHT I 3 .   ? -14.208 20.062  3.67    0.5  92.01  ? 501 HHT B O1  1 
HETATM 8914 C  C2  A HHT I 3 .   ? -14.245 17.957  0.458   0.25 131.82 ? 501 HHT B C2  1 
HETATM 8915 C  C2  B HHT I 3 .   ? -18.564 18.952  4.719   0.25 91.76  ? 501 HHT B C2  1 
HETATM 8916 C  C2  C HHT I 3 .   ? -13.783 18.919  3.101   0.5  91.76  ? 501 HHT B C2  1 
HETATM 8917 BR BR1 A HHT I 3 .   ? -16.198 15.154  2.792   0.25 296.22 ? 501 HHT B BR1 1 
HETATM 8918 BR BR1 B HHT I 3 .   ? -17.411 15.072  3.911   0.25 75.27  ? 501 HHT B BR1 1 
HETATM 8919 BR BR1 C HHT I 3 .   ? -15.057 15.239  1.807   0.5  75.27  ? 501 HHT B BR1 1 
HETATM 8920 O  O2  A HHT I 3 .   ? -10.047 17.197  0.509   0.25 111.53 ? 501 HHT B O2  1 
HETATM 8921 O  O2  B HHT I 3 .   ? -18.316 21.358  2.425   0.25 75.96  ? 501 HHT B O2  1 
HETATM 8922 O  O2  C HHT I 3 .   ? -10.844 18.774  4.569   0.5  75.96  ? 501 HHT B O2  1 
HETATM 8923 O  O3  A HHT I 3 .   ? -10.197 16.562  -1.589  0.25 111.54 ? 501 HHT B O3  1 
HETATM 8924 O  O3  B HHT I 3 .   ? -19.593 22.871  3.399   0.25 79.27  ? 501 HHT B O3  1 
HETATM 8925 O  O3  C HHT I 3 .   ? -9.626  20.589  4.132   0.5  79.27  ? 501 HHT B O3  1 
HETATM 8926 C  C4  . HHT J 3 .   ? -33.985 -16.179 -1.704  1    109.33 ? 502 HHT B C4  1 
HETATM 8927 C  C5  . HHT J 3 .   ? -33.391 -16.031 -0.448  1    71.88  ? 502 HHT B C5  1 
HETATM 8928 C  C6  . HHT J 3 .   ? -34.141 -15.547 0.613   1    67.57  ? 502 HHT B C6  1 
HETATM 8929 C  C7  . HHT J 3 .   ? -35.496 -15.281 0.473   1    95.7   ? 502 HHT B C7  1 
HETATM 8930 C  C8  . HHT J 3 .   ? -36.329 -14.705 1.587   1    110.27 ? 502 HHT B C8  1 
HETATM 8931 C  C9  . HHT J 3 .   ? -36.466 -13.198 1.284   1    109.51 ? 502 HHT B C9  1 
HETATM 8932 C  C3  . HHT J 3 .   ? -35.326 -15.858 -1.908  1    96.19  ? 502 HHT B C3  1 
HETATM 8933 C  C1  . HHT J 3 .   ? -37.828 -14.035 -1.683  1    108.4  ? 502 HHT B C1  1 
HETATM 8934 O  O1  . HHT J 3 .   ? -37.417 -15.12  -0.857  1    99.4   ? 502 HHT B O1  1 
HETATM 8935 C  C2  . HHT J 3 .   ? -36.102 -15.528 -0.805  1    102.65 ? 502 HHT B C2  1 
HETATM 8936 BR BR1 . HHT J 3 .   ? -32.942 -16.776 -3.214  1    95.45  ? 502 HHT B BR1 1 
HETATM 8937 O  O2  . HHT J 3 .   ? -37.607 -12.641 1.324   1    81.82  ? 502 HHT B O2  1 
HETATM 8938 O  O3  . HHT J 3 .   ? -35.415 -12.563 0.959   1    79.15  ? 502 HHT B O3  1 
HETATM 8939 C  C4  . HHT K 3 .   ? -32.622 16.514  28.761  1    53.4   ? 501 HHT C C4  1 
HETATM 8940 C  C5  . HHT K 3 .   ? -32.675 15.332  28.069  1    50.74  ? 501 HHT C C5  1 
HETATM 8941 C  C6  . HHT K 3 .   ? -32.913 14.171  28.791  1    53.2   ? 501 HHT C C6  1 
HETATM 8942 C  C7  . HHT K 3 .   ? -33.109 14.186  30.166  1    49.93  ? 501 HHT C C7  1 
HETATM 8943 C  C8  . HHT K 3 .   ? -33.34  12.915  30.924  1    52.17  ? 501 HHT C C8  1 
HETATM 8944 C  C9  . HHT K 3 .   ? -34.76  12.685  31.409  1    55.22  ? 501 HHT C C9  1 
HETATM 8945 C  C3  . HHT K 3 .   ? -32.77  16.601  30.137  1    52.09  ? 501 HHT C C3  1 
HETATM 8946 C  C1  . HHT K 3 .   ? -33.233 16.677  32.857  1    48.35  ? 501 HHT C C1  1 
HETATM 8947 O  O1  . HHT K 3 .   ? -33.223 15.416  32.197  1    54.41  ? 501 HHT C O1  1 
HETATM 8948 C  C2  . HHT K 3 .   ? -33.019 15.435  30.842  1    53.26  ? 501 HHT C C2  1 
HETATM 8949 BR BR1 . HHT K 3 .   ? -32.284 18.104  27.823  1    54.61  ? 501 HHT C BR1 1 
HETATM 8950 O  O2  . HHT K 3 .   ? -34.923 12.019  32.432  1    57.92  ? 501 HHT C O2  1 
HETATM 8951 O  O3  . HHT K 3 .   ? -35.689 13.156  30.734  1    60.26  ? 501 HHT C O3  1 
HETATM 8952 C  C4  . HHT L 3 .   ? -21.889 12.594  34.794  1    70.81  ? 502 HHT C C4  1 
HETATM 8953 C  C5  . HHT L 3 .   ? -21.763 12.892  36.145  1    66.04  ? 502 HHT C C5  1 
HETATM 8954 C  C6  . HHT L 3 .   ? -20.539 12.679  36.752  1    68.47  ? 502 HHT C C6  1 
HETATM 8955 C  C7  . HHT L 3 .   ? -19.459 12.179  36.046  1    69.7   ? 502 HHT C C7  1 
HETATM 8956 C  C8  . HHT L 3 .   ? -18.133 11.942  36.698  1    82.97  ? 502 HHT C C8  1 
HETATM 8957 C  C9  . HHT L 3 .   ? -17.939 10.464  37.008  1    88.74  ? 502 HHT C C9  1 
HETATM 8958 C  C3  . HHT L 3 .   ? -20.843 12.103  34.031  1    61.24  ? 502 HHT C C3  1 
HETATM 8959 C  C1  . HHT L 3 .   ? -18.474 11.216  32.612  1    76.36  ? 502 HHT C C1  1 
HETATM 8960 O  O1  . HHT L 3 .   ? -18.5   11.388  34.034  1    85.7   ? 502 HHT C O1  1 
HETATM 8961 C  C2  . HHT L 3 .   ? -19.628 11.878  34.666  1    79.81  ? 502 HHT C C2  1 
HETATM 8962 BR BR1 . HHT L 3 .   ? -23.557 12.86   33.939  1    66.38  ? 502 HHT C BR1 1 
HETATM 8963 O  O2  . HHT L 3 .   ? -18.908 9.799   37.443  1    94.19  ? 502 HHT C O2  1 
HETATM 8964 O  O3  . HHT L 3 .   ? -16.806 10      36.82   1    94.89  ? 502 HHT C O3  1 
HETATM 8965 C  C4  . HHT M 3 .   ? -19.026 14.797  32.741  1    95.3   ? 503 HHT C C4  1 
HETATM 8966 C  C5  . HHT M 3 .   ? -19.848 15.511  33.571  1    81.93  ? 503 HHT C C5  1 
HETATM 8967 C  C6  . HHT M 3 .   ? -19.41  15.817  34.855  1    92.99  ? 503 HHT C C6  1 
HETATM 8968 C  C7  . HHT M 3 .   ? -18.182 15.402  35.332  1    94.53  ? 503 HHT C C7  1 
HETATM 8969 C  C8  . HHT M 3 .   ? -17.712 15.75   36.715  1    105.27 ? 503 HHT C C8  1 
HETATM 8970 C  C9  . HHT M 3 .   ? -16.578 16.772  36.647  1    122.44 ? 503 HHT C C9  1 
HETATM 8971 C  C3  . HHT M 3 .   ? -17.77  14.383  33.151  1    101.83 ? 503 HHT C C3  1 
HETATM 8972 C  C1  . HHT M 3 .   ? -15.243 13.52   34.121  1    92.68  ? 503 HHT C C1  1 
HETATM 8973 O  O1  . HHT M 3 .   ? -16.109 14.317  34.932  1    113.65 ? 503 HHT C O1  1 
HETATM 8974 C  C2  . HHT M 3 .   ? -17.339 14.695  34.433  1    104.9  ? 503 HHT C C2  1 
HETATM 8975 BR BR1 . HHT M 3 .   ? -19.599 14.386  30.976  1    96.53  ? 503 HHT C BR1 1 
HETATM 8976 O  O2  . HHT M 3 .   ? -15.473 16.487  37.169  1    109.05 ? 503 HHT C O2  1 
HETATM 8977 O  O3  . HHT M 3 .   ? -16.801 17.84   36.034  1    126.33 ? 503 HHT C O3  1 
HETATM 8978 C  C4  . HHT N 3 .   ? -32.839 -24.395 45.713  1    93.24  ? 501 HHT D C4  1 
HETATM 8979 C  C5  . HHT N 3 .   ? -33.947 -24.362 46.539  1    87.34  ? 501 HHT D C5  1 
HETATM 8980 C  C6  . HHT N 3 .   ? -33.809 -24.726 47.867  1    88.4   ? 501 HHT D C6  1 
HETATM 8981 C  C7  . HHT N 3 .   ? -32.588 -25.134 48.386  1    117.38 ? 501 HHT D C7  1 
HETATM 8982 C  C8  . HHT N 3 .   ? -32.46  -25.55  49.827  1    129.66 ? 501 HHT D C8  1 
HETATM 8983 C  C9  . HHT N 3 .   ? -33.297 -26.779 50.181  1    135.07 ? 501 HHT D C9  1 
HETATM 8984 C  C3  . HHT N 3 .   ? -31.591 -24.792 46.164  1    90.46  ? 501 HHT D C3  1 
HETATM 8985 C  C1  . HHT N 3 .   ? -29.046 -25.519 47.232  1    103.47 ? 501 HHT D C1  1 
HETATM 8986 O  O1  . HHT N 3 .   ? -30.235 -25.552 48.029  1    132.29 ? 501 HHT D O1  1 
HETATM 8987 C  C2  . HHT N 3 .   ? -31.45  -25.165 47.489  1    114.94 ? 501 HHT D C2  1 
HETATM 8988 BR BR1 . HHT N 3 .   ? -32.997 -23.867 43.892  1    113.73 ? 501 HHT D BR1 1 
HETATM 8989 O  O2  . HHT N 3 .   ? -32.78  -27.663 50.906  1    140.85 ? 501 HHT D O2  1 
HETATM 8990 O  O3  . HHT N 3 .   ? -34.455 -26.859 49.707  1    129.06 ? 501 HHT D O3  1 
HETATM 8991 O  O   . HOH O 4 .   ? 4.555   -19.483 -5.013  1    50.95  ? 701 HOH A O   1 
HETATM 8992 O  O   . HOH O 4 .   ? -6.326  -22.459 -7.451  1    55.43  ? 702 HOH A O   1 
HETATM 8993 O  O   . HOH O 4 .   ? 5.105   -42.07  0.939   1    51.56  ? 703 HOH A O   1 
HETATM 8994 O  O   . HOH O 4 .   ? -13.651 -11.861 -3.252  1    46.58  ? 704 HOH A O   1 
HETATM 8995 O  O   . HOH O 4 .   ? -5.057  -38.026 -4.538  1    43.6   ? 705 HOH A O   1 
HETATM 8996 O  O   . HOH O 4 .   ? 15.114  -31.585 -14.012 1    40.11  ? 706 HOH A O   1 
HETATM 8997 O  O   . HOH O 4 .   ? 1.261   -25.875 25.994  1    65     ? 707 HOH A O   1 
HETATM 8998 O  O   . HOH O 4 .   ? -15.699 -38.078 19.217  1    45.08  ? 708 HOH A O   1 
HETATM 8999 O  O   . HOH O 4 .   ? -12.92  -28.859 -5.07   1    35.37  ? 709 HOH A O   1 
HETATM 9000 O  O   . HOH O 4 .   ? -16.721 -22.82  28.057  1    56.98  ? 710 HOH A O   1 
HETATM 9001 O  O   . HOH O 4 .   ? -19.617 -33.167 18.892  1    52.64  ? 711 HOH A O   1 
HETATM 9002 O  O   . HOH O 4 .   ? -2.172  -24.4   8.61    1    47.41  ? 712 HOH A O   1 
HETATM 9003 O  O   . HOH O 4 .   ? -18.715 -16.286 31.066  1    47.13  ? 713 HOH A O   1 
HETATM 9004 O  O   . HOH O 4 .   ? -13.904 -36.158 -4.976  1    50.52  ? 714 HOH A O   1 
HETATM 9005 O  O   . HOH O 4 .   ? -3.143  -12.539 6.074   1    43.27  ? 715 HOH A O   1 
HETATM 9006 O  O   . HOH O 4 .   ? -19.41  -15.383 42.665  1    45.48  ? 716 HOH A O   1 
HETATM 9007 O  O   . HOH O 4 .   ? -0.503  -13.743 6.033   1    52.78  ? 717 HOH A O   1 
HETATM 9008 O  O   . HOH O 4 .   ? -15.757 -31.187 27.818  1    57.33  ? 718 HOH A O   1 
HETATM 9009 O  O   . HOH O 4 .   ? 5.104   -32.107 -14.652 1    50.09  ? 719 HOH A O   1 
HETATM 9010 O  O   . HOH O 4 .   ? -13.393 -47.858 8.093   1    62.56  ? 720 HOH A O   1 
HETATM 9011 O  O   . HOH O 4 .   ? -9.68   -47.176 -2.007  1    53.29  ? 721 HOH A O   1 
HETATM 9012 O  O   . HOH O 4 .   ? 1.222   -38.703 8.073   1    36.1   ? 722 HOH A O   1 
HETATM 9013 O  O   . HOH O 4 .   ? -25.004 -20.864 4.429   1    53.15  ? 723 HOH A O   1 
HETATM 9014 O  O   . HOH O 4 .   ? -17.986 -18.617 17.236  1    42.11  ? 724 HOH A O   1 
HETATM 9015 O  O   . HOH O 4 .   ? -3.261  -43     15.364  1    51.47  ? 725 HOH A O   1 
HETATM 9016 O  O   . HOH O 4 .   ? 2.545   -18.571 0.48    1    54.18  ? 726 HOH A O   1 
HETATM 9017 O  O   . HOH O 4 .   ? -23.141 -10.471 7.869   1    51.08  ? 727 HOH A O   1 
HETATM 9018 O  O   . HOH O 4 .   ? 0.152   -33.619 8.201   1    36.23  ? 728 HOH A O   1 
HETATM 9019 O  O   . HOH O 4 .   ? 9.065   -22.713 -8.083  1    64.33  ? 729 HOH A O   1 
HETATM 9020 O  O   . HOH O 4 .   ? -11.751 -16.649 -9.37   1    57.26  ? 730 HOH A O   1 
HETATM 9021 O  O   . HOH O 4 .   ? -12.508 -12.906 -9.425  1    52.31  ? 731 HOH A O   1 
HETATM 9022 O  O   . HOH O 4 .   ? -16.831 -27.009 24.981  1    56.12  ? 732 HOH A O   1 
HETATM 9023 O  O   . HOH O 4 .   ? -4.837  -9.437  7.942   1    48.53  ? 733 HOH A O   1 
HETATM 9024 O  O   . HOH O 4 .   ? -14.332 -46.19  -0.594  1    53     ? 734 HOH A O   1 
HETATM 9025 O  O   . HOH O 4 .   ? -2.897  -20.072 -5.555  1    33.95  ? 735 HOH A O   1 
HETATM 9026 O  O   . HOH O 4 .   ? 1.768   -32.472 6.174   1    32.73  ? 736 HOH A O   1 
HETATM 9027 O  O   . HOH O 4 .   ? -12.7   -34.583 22.035  1    51.79  ? 737 HOH A O   1 
HETATM 9028 O  O   . HOH O 4 .   ? -3.9    -25.506 2.274   1    35.09  ? 738 HOH A O   1 
HETATM 9029 O  O   . HOH O 4 .   ? 3.883   -21.039 -0.777  1    34.43  ? 739 HOH A O   1 
HETATM 9030 O  O   . HOH O 4 .   ? -6.771  -35.927 29.381  1    51.99  ? 740 HOH A O   1 
HETATM 9031 O  O   . HOH O 4 .   ? -7.644  -18.769 10.572  1    30.88  ? 741 HOH A O   1 
HETATM 9032 O  O   . HOH O 4 .   ? -21.927 -19.049 27.899  1    45.24  ? 742 HOH A O   1 
HETATM 9033 O  O   . HOH O 4 .   ? -21.873 -28.771 7.99    1    32.99  ? 743 HOH A O   1 
HETATM 9034 O  O   . HOH O 4 .   ? -23.195 -34.829 2.102   1    47.08  ? 744 HOH A O   1 
HETATM 9035 O  O   . HOH O 4 .   ? -5.246  -16.028 -4.507  1    39.61  ? 745 HOH A O   1 
HETATM 9036 O  O   . HOH O 4 .   ? 13.523  -27.306 -10.474 1    46.68  ? 746 HOH A O   1 
HETATM 9037 O  O   . HOH O 4 .   ? -8.167  -23.85  -4.309  1    31.71  ? 747 HOH A O   1 
HETATM 9038 O  O   . HOH O 4 .   ? -12.526 -11.097 5.443   1    33.61  ? 748 HOH A O   1 
HETATM 9039 O  O   . HOH O 4 .   ? 8.182   -44.214 -2.888  1    51.4   ? 749 HOH A O   1 
HETATM 9040 O  O   . HOH O 4 .   ? -8.175  -33.155 -13.205 1    45.43  ? 750 HOH A O   1 
HETATM 9041 O  O   . HOH O 4 .   ? -19.241 -24.565 19.384  1    27.91  ? 751 HOH A O   1 
HETATM 9042 O  O   . HOH O 4 .   ? -5.18   -42.639 -5.822  1    52.06  ? 752 HOH A O   1 
HETATM 9043 O  O   . HOH O 4 .   ? -1.456  -17.86  -3.394  1    36.62  ? 753 HOH A O   1 
HETATM 9044 O  O   . HOH O 4 .   ? -1.478  -15.256 -5.931  1    52.79  ? 754 HOH A O   1 
HETATM 9045 O  O   . HOH O 4 .   ? -10.167 -29.028 -14.048 1    47.47  ? 755 HOH A O   1 
HETATM 9046 O  O   . HOH O 4 .   ? -6.955  -52.278 2.679   1    70.24  ? 756 HOH A O   1 
HETATM 9047 O  O   . HOH O 4 .   ? -14.318 -27.228 -1.532  1    32.48  ? 757 HOH A O   1 
HETATM 9048 O  O   . HOH O 4 .   ? -6.656  -12.4   16.04   1    65.68  ? 758 HOH A O   1 
HETATM 9049 O  O   . HOH O 4 .   ? -22.057 -36.116 29.743  1    65.28  ? 759 HOH A O   1 
HETATM 9050 O  O   . HOH O 4 .   ? -12.445 -28.912 -2.372  1    32.59  ? 760 HOH A O   1 
HETATM 9051 O  O   . HOH O 4 .   ? -0.921  -24.938 -18.857 1    63.36  ? 761 HOH A O   1 
HETATM 9052 O  O   . HOH O 4 .   ? -2.942  -16.74  15.883  1    60.24  ? 762 HOH A O   1 
HETATM 9053 O  O   . HOH O 4 .   ? 10.977  -21.289 1.138   1    60.18  ? 763 HOH A O   1 
HETATM 9054 O  O   . HOH O 4 .   ? -19.124 -10.573 32.882  1    63.81  ? 764 HOH A O   1 
HETATM 9055 O  O   . HOH O 4 .   ? -15.74  -23.486 37.429  1    61.51  ? 765 HOH A O   1 
HETATM 9056 O  O   . HOH O 4 .   ? 1.063   -29.691 2.407   1    33.05  ? 766 HOH A O   1 
HETATM 9057 O  O   . HOH O 4 .   ? 12.483  -32.658 -15.331 1    41.11  ? 767 HOH A O   1 
HETATM 9058 O  O   . HOH O 4 .   ? -4.557  -8.668  5.207   1    57.72  ? 768 HOH A O   1 
HETATM 9059 O  O   . HOH O 4 .   ? -18.452 -38.436 -1.342  1    50.94  ? 769 HOH A O   1 
HETATM 9060 O  O   . HOH O 4 .   ? -14.563 -49.759 10.342  1    66.66  ? 770 HOH A O   1 
HETATM 9061 O  O   . HOH O 4 .   ? 2.988   -27.741 18.019  1    57.31  ? 771 HOH A O   1 
HETATM 9062 O  O   . HOH O 4 .   ? -2.638  -15.699 -3.513  1    34.87  ? 772 HOH A O   1 
HETATM 9063 O  O   . HOH O 4 .   ? -9.486  -52.282 3.499   1    59.27  ? 773 HOH A O   1 
HETATM 9064 O  O   . HOH O 4 .   ? 14.321  -37.953 -5.33   1    52.36  ? 774 HOH A O   1 
HETATM 9065 O  O   . HOH O 4 .   ? -17.397 -48.916 0.399   1    59.92  ? 775 HOH A O   1 
HETATM 9066 O  O   . HOH O 4 .   ? -21.145 -42.493 5.295   1    48.37  ? 776 HOH A O   1 
HETATM 9067 O  O   . HOH O 4 .   ? -4.444  -18.64  12.611  1    49.98  ? 777 HOH A O   1 
HETATM 9068 O  O   . HOH O 4 .   ? -22.961 -15.413 17.879  1    54.93  ? 778 HOH A O   1 
HETATM 9069 O  O   . HOH O 4 .   ? 2.322   -32.147 -18.898 1    55.32  ? 779 HOH A O   1 
HETATM 9070 O  O   . HOH O 4 .   ? -19.193 -31.302 23.194  1    47.35  ? 780 HOH A O   1 
HETATM 9071 O  O   . HOH O 4 .   ? 14.243  -25.691 -8.492  1    45.68  ? 781 HOH A O   1 
HETATM 9072 O  O   . HOH O 4 .   ? -19.01  -37.863 15.74   1    61     ? 782 HOH A O   1 
HETATM 9073 O  O   . HOH O 4 .   ? -20.792 -36.531 23.797  1    51.08  ? 783 HOH A O   1 
HETATM 9074 O  O   . HOH O 4 .   ? -23.787 -42.687 15.365  1    47.54  ? 784 HOH A O   1 
HETATM 9075 O  O   . HOH O 4 .   ? -19.9   -30.248 19.65   1    53.33  ? 785 HOH A O   1 
HETATM 9076 O  O   . HOH O 4 .   ? -3.673  -6.211  7.075   1    55.69  ? 786 HOH A O   1 
HETATM 9077 O  O   . HOH O 4 .   ? 0.312   -37.492 -10.146 1    42.17  ? 787 HOH A O   1 
HETATM 9078 O  O   . HOH O 4 .   ? -12.864 -49.886 4.254   1    45.43  ? 788 HOH A O   1 
HETATM 9079 O  O   . HOH O 4 .   ? 15.19   -27.274 1.451   1    63.9   ? 789 HOH A O   1 
HETATM 9080 O  O   . HOH O 4 .   ? 1.194   -11.8   4.055   1    62.12  ? 790 HOH A O   1 
HETATM 9081 O  O   . HOH O 4 .   ? -20.546 -15.947 18.252  1    60.94  ? 791 HOH A O   1 
HETATM 9082 O  O   . HOH O 4 .   ? 14.381  -32.933 2.361   1    53.5   ? 792 HOH A O   1 
HETATM 9083 O  O   . HOH O 4 .   ? -6.369  -25.382 -11.286 1    41.49  ? 793 HOH A O   1 
HETATM 9084 O  O   . HOH O 4 .   ? 11.935  -22.524 -1.475  1    42.41  ? 794 HOH A O   1 
HETATM 9085 O  O   . HOH O 4 .   ? -2.572  -8.826  8.749   1    47.75  ? 795 HOH A O   1 
HETATM 9086 O  O   . HOH O 4 .   ? -16.053 -41.977 -2.977  1    39.11  ? 796 HOH A O   1 
HETATM 9087 O  O   . HOH O 4 .   ? -19.665 -39.059 23.992  1    57.08  ? 797 HOH A O   1 
HETATM 9088 O  O   . HOH O 4 .   ? -4.984  -19.496 -10.488 1    39.1   ? 798 HOH A O   1 
HETATM 9089 O  O   . HOH O 4 .   ? -14.72  -12.033 -8.738  1    51.4   ? 799 HOH A O   1 
HETATM 9090 O  O   . HOH O 4 .   ? 7.5     -22.428 -4.659  1    61.72  ? 800 HOH A O   1 
HETATM 9091 O  O   . HOH O 4 .   ? 0.217   -27.625 20.285  1    54.34  ? 801 HOH A O   1 
HETATM 9092 O  O   . HOH O 4 .   ? -25.143 -24.938 13.242  1    48.7   ? 802 HOH A O   1 
HETATM 9093 O  O   . HOH O 4 .   ? -16.638 -46.077 13.993  1    58.57  ? 803 HOH A O   1 
HETATM 9094 O  O   . HOH O 4 .   ? 3.293   -40.138 6.862   1    56.32  ? 804 HOH A O   1 
HETATM 9095 O  O   . HOH O 4 .   ? 2.677   -24.984 14.221  1    55.19  ? 805 HOH A O   1 
HETATM 9096 O  O   . HOH O 4 .   ? -2.568  -19.12  -11.909 1    37.67  ? 806 HOH A O   1 
HETATM 9097 O  O   . HOH O 4 .   ? -8.003  -26.974 -14.173 1    60.63  ? 807 HOH A O   1 
HETATM 9098 O  O   . HOH O 4 .   ? -3.588  -4.55   10.657  1    57.21  ? 808 HOH A O   1 
HETATM 9099 O  O   . HOH O 4 .   ? -22.586 -41.102 17.493  1    55.73  ? 809 HOH A O   1 
HETATM 9100 O  O   . HOH O 4 .   ? -18.146 -24.394 32.008  1    51.08  ? 810 HOH A O   1 
HETATM 9101 O  O   . HOH O 4 .   ? -22.311 -43.730 0.945   1    55.1   ? 811 HOH A O   1 
HETATM 9102 O  O   . HOH O 4 .   ? -0.244  -11.556 -1.565  1    44.07  ? 812 HOH A O   1 
HETATM 9103 O  O   . HOH O 4 .   ? 6.775   -19.821 2.949   1    54.52  ? 813 HOH A O   1 
HETATM 9104 O  O   . HOH O 4 .   ? 12.694  -31.428 -17.518 1    57.88  ? 814 HOH A O   1 
HETATM 9105 O  O   . HOH O 4 .   ? 1.62    -15.527 -5.345  1    52.02  ? 815 HOH A O   1 
HETATM 9106 O  O   . HOH O 4 .   ? 10.658  -38.150 0.594   1    56.6   ? 816 HOH A O   1 
HETATM 9107 O  O   . HOH O 4 .   ? -15.71  -44.517 -2.291  1    47.57  ? 817 HOH A O   1 
HETATM 9108 O  O   . HOH O 4 .   ? -6.506  -22.318 19.219  1    62.39  ? 818 HOH A O   1 
HETATM 9109 O  O   . HOH O 4 .   ? -15.903 -31.925 -8.216  1    52.17  ? 819 HOH A O   1 
HETATM 9110 O  O   . HOH O 4 .   ? -6.922  -51.656 6.952   1    59.98  ? 820 HOH A O   1 
HETATM 9111 O  O   . HOH O 4 .   ? -8.806  -24.019 -9.79   1    57.76  ? 821 HOH A O   1 
HETATM 9112 O  O   . HOH O 4 .   ? -16.451 -51.194 5.005   1    73.46  ? 822 HOH A O   1 
HETATM 9113 O  O   . HOH O 4 .   ? -6.048  -25.401 25.499  1    51.28  ? 823 HOH A O   1 
HETATM 9114 O  O   . HOH O 4 .   ? 13.057  -34.785 7.868   1    56.64  ? 824 HOH A O   1 
HETATM 9115 O  O   . HOH O 4 .   ? 13.644  -35.569 2.351   1    50.22  ? 825 HOH A O   1 
HETATM 9116 O  O   . HOH O 4 .   ? -6.652  -44.608 -3.359  1    53.11  ? 826 HOH A O   1 
HETATM 9117 O  O   . HOH O 4 .   ? 13.764  -28.837 -18.229 1    59.51  ? 827 HOH A O   1 
HETATM 9118 O  O   . HOH O 4 .   ? 3.636   -27.291 12.24   1    60.54  ? 828 HOH A O   1 
HETATM 9119 O  O   . HOH O 4 .   ? -17.928 -41.005 -1.825  1    54.26  ? 829 HOH A O   1 
HETATM 9120 O  O   . HOH O 4 .   ? 7.829   -24.704 8.468   1    66.2   ? 830 HOH A O   1 
HETATM 9121 O  O   . HOH O 4 .   ? -22.313 -44.482 3.49    1    61.08  ? 831 HOH A O   1 
HETATM 9122 O  O   . HOH O 4 .   ? 12.639  -41.920 -6.971  1    57.97  ? 832 HOH A O   1 
HETATM 9123 O  O   . HOH O 4 .   ? 2.195   -24.25  23.097  1    53.66  ? 833 HOH A O   1 
HETATM 9124 O  O   . HOH O 4 .   ? 10.775  -34.1   9.812   1    50.77  ? 834 HOH A O   1 
HETATM 9125 O  O   . HOH O 4 .   ? 6.048   -23.822 10.216  1    58.45  ? 835 HOH A O   1 
HETATM 9126 O  O   . HOH P 4 .   ? -35.137 -3.139  -20.589 1    55.66  ? 601 HOH B O   1 
HETATM 9127 O  O   . HOH P 4 .   ? -19.935 -9.244  10.174  1    42.77  ? 602 HOH B O   1 
HETATM 9128 O  O   . HOH P 4 .   ? -30.59  16.37   7.458   1    55.69  ? 603 HOH B O   1 
HETATM 9129 O  O   . HOH P 4 .   ? -25.965 2       2.024   1    62.56  ? 604 HOH B O   1 
HETATM 9130 O  O   . HOH P 4 .   ? -13.846 -10.842 -0.343  1    45.18  ? 605 HOH B O   1 
HETATM 9131 O  O   . HOH P 4 .   ? -13.739 13.976  -4.603  1    58.61  ? 606 HOH B O   1 
HETATM 9132 O  O   . HOH P 4 .   ? -24.498 16.346  -4.593  1    55.95  ? 607 HOH B O   1 
HETATM 9133 O  O   . HOH P 4 .   ? -35.102 -21.843 -8.524  1    52.28  ? 608 HOH B O   1 
HETATM 9134 O  O   . HOH P 4 .   ? -22.749 3.422   -26.206 1    69.95  ? 609 HOH B O   1 
HETATM 9135 O  O   . HOH P 4 .   ? -12.792 -10.29  2.799   1    37.56  ? 610 HOH B O   1 
HETATM 9136 O  O   . HOH P 4 .   ? -4.591  -4.419  -0.886  1    48.21  ? 611 HOH B O   1 
HETATM 9137 O  O   . HOH P 4 .   ? -8.438  2.164   16.722  1    47.95  ? 612 HOH B O   1 
HETATM 9138 O  O   . HOH P 4 .   ? -27.474 12.462  -3.555  1    47.69  ? 613 HOH B O   1 
HETATM 9139 O  O   . HOH P 4 .   ? -29.182 9.291   -8.861  1    53.16  ? 614 HOH B O   1 
HETATM 9140 O  O   . HOH P 4 .   ? -32.477 -10.209 0.704   1    31.07  ? 615 HOH B O   1 
HETATM 9141 O  O   . HOH P 4 .   ? -36.9   -13.307 -4.078  1    49.18  ? 616 HOH B O   1 
HETATM 9142 O  O   . HOH P 4 .   ? -22.522 -0.958  0.488   1    41.31  ? 617 HOH B O   1 
HETATM 9143 O  O   . HOH P 4 .   ? -21.653 21.918  11.881  1    55.67  ? 618 HOH B O   1 
HETATM 9144 O  O   . HOH P 4 .   ? -32.382 8.88    4.639   1    63.99  ? 619 HOH B O   1 
HETATM 9145 O  O   . HOH P 4 .   ? -8.621  -22.808 -7.04   1    45.41  ? 620 HOH B O   1 
HETATM 9146 O  O   . HOH P 4 .   ? -27.033 10.666  -12.362 1    57.17  ? 621 HOH B O   1 
HETATM 9147 O  O   . HOH P 4 .   ? -38.928 3.868   -9.278  1    58.73  ? 622 HOH B O   1 
HETATM 9148 O  O   . HOH P 4 .   ? -26.333 15.619  11.584  1    56.94  ? 623 HOH B O   1 
HETATM 9149 O  O   . HOH P 4 .   ? -16.392 -8.424  1.543   1    32.32  ? 624 HOH B O   1 
HETATM 9150 O  O   . HOH P 4 .   ? 3.838   -9.414  -2.09   1    59.13  ? 625 HOH B O   1 
HETATM 9151 O  O   . HOH P 4 .   ? -24.822 -14.736 11.045  1    52.93  ? 626 HOH B O   1 
HETATM 9152 O  O   . HOH P 4 .   ? -28.416 -17.939 -17.962 1    60.79  ? 627 HOH B O   1 
HETATM 9153 O  O   . HOH P 4 .   ? -16.394 16.579  7.593   1    54.9   ? 628 HOH B O   1 
HETATM 9154 O  O   . HOH P 4 .   ? -28.047 -4.067  3.172   1    42.14  ? 629 HOH B O   1 
HETATM 9155 O  O   . HOH P 4 .   ? -18.204 -1.107  -7.871  1    41.91  ? 630 HOH B O   1 
HETATM 9156 O  O   . HOH P 4 .   ? -6.053  -6.404  5.759   1    35.25  ? 631 HOH B O   1 
HETATM 9157 O  O   . HOH P 4 .   ? -26.315 10.802  -0.862  1    43.43  ? 632 HOH B O   1 
HETATM 9158 O  O   . HOH P 4 .   ? -19.803 -13.197 -0.623  1    41.99  ? 633 HOH B O   1 
HETATM 9159 O  O   . HOH P 4 .   ? -17.927 -13.696 -14.998 1    49.23  ? 634 HOH B O   1 
HETATM 9160 O  O   . HOH P 4 .   ? -37.587 -7.533  -6.265  1    49.31  ? 635 HOH B O   1 
HETATM 9161 O  O   . HOH P 4 .   ? -6.399  -3.495  -3.911  1    40.06  ? 636 HOH B O   1 
HETATM 9162 O  O   . HOH P 4 .   ? -32.989 8.217   -10.314 1    52.39  ? 637 HOH B O   1 
HETATM 9163 O  O   . HOH P 4 .   ? -21.971 4.357   -19.867 1    53.97  ? 638 HOH B O   1 
HETATM 9164 O  O   . HOH P 4 .   ? -12.765 3.87    -6.038  1    40.77  ? 639 HOH B O   1 
HETATM 9165 O  O   . HOH P 4 .   ? -3.502  -1.045  -3.12   1    64.23  ? 640 HOH B O   1 
HETATM 9166 O  O   . HOH P 4 .   ? -33.488 16.784  11.814  1    60.38  ? 641 HOH B O   1 
HETATM 9167 O  O   . HOH P 4 .   ? -16.763 14.622  -8.491  1    58.2   ? 642 HOH B O   1 
HETATM 9168 O  O   . HOH P 4 .   ? -6.084  14.759  18.546  1    54.65  ? 643 HOH B O   1 
HETATM 9169 O  O   . HOH P 4 .   ? -22.278 11.121  -12.172 1    46.33  ? 644 HOH B O   1 
HETATM 9170 O  O   . HOH P 4 .   ? -19.223 20.715  12.151  1    46.67  ? 645 HOH B O   1 
HETATM 9171 O  O   . HOH P 4 .   ? -15.237 -17.024 -13.163 1    51.32  ? 646 HOH B O   1 
HETATM 9172 O  O   . HOH P 4 .   ? -31.928 9.908   2.314   1    64.24  ? 647 HOH B O   1 
HETATM 9173 O  O   . HOH P 4 .   ? -15.334 -27.483 0.889   1    32.86  ? 648 HOH B O   1 
HETATM 9174 O  O   . HOH P 4 .   ? -30.748 15.573  2.786   1    47.23  ? 649 HOH B O   1 
HETATM 9175 O  O   . HOH P 4 .   ? -18.18  -13.221 -11.959 1    45.71  ? 650 HOH B O   1 
HETATM 9176 O  O   . HOH P 4 .   ? -24.306 -24.361 -4.478  1    38.08  ? 651 HOH B O   1 
HETATM 9177 O  O   . HOH P 4 .   ? -26.859 5.095   -1.749  1    42.71  ? 652 HOH B O   1 
HETATM 9178 O  O   . HOH P 4 .   ? -35.42  -8.662  -1.661  1    29.14  ? 653 HOH B O   1 
HETATM 9179 O  O   . HOH P 4 .   ? -29.228 16.991  0.028   1    45.45  ? 654 HOH B O   1 
HETATM 9180 O  O   . HOH P 4 .   ? -31.91  10.652  -11.558 1    59.91  ? 655 HOH B O   1 
HETATM 9181 O  O   . HOH P 4 .   ? -39.163 2.656   -4.864  1    60.1   ? 656 HOH B O   1 
HETATM 9182 O  O   . HOH P 4 .   ? -30.552 -19.326 -5.137  1    57.54  ? 657 HOH B O   1 
HETATM 9183 O  O   . HOH P 4 .   ? -32.572 -11.618 -23.233 1    61.99  ? 658 HOH B O   1 
HETATM 9184 O  O   . HOH P 4 .   ? -29.82  11.622  -2.726  1    43.26  ? 659 HOH B O   1 
HETATM 9185 O  O   . HOH P 4 .   ? -29.806 11.091  13.813  1    52.31  ? 660 HOH B O   1 
HETATM 9186 O  O   . HOH P 4 .   ? -25.877 1.71    -3.171  1    40.19  ? 661 HOH B O   1 
HETATM 9187 O  O   . HOH P 4 .   ? -24.778 -24.449 -1.71   1    35.82  ? 662 HOH B O   1 
HETATM 9188 O  O   . HOH P 4 .   ? -32.949 -25.597 -3.486  1    54.59  ? 663 HOH B O   1 
HETATM 9189 O  O   . HOH P 4 .   ? -37.223 -2.689  -7.472  1    50.47  ? 664 HOH B O   1 
HETATM 9190 O  O   . HOH P 4 .   ? -30.293 18.693  7.772   1    64.86  ? 665 HOH B O   1 
HETATM 9191 O  O   . HOH P 4 .   ? -30.615 -12.265 -5.042  1    39.74  ? 666 HOH B O   1 
HETATM 9192 O  O   . HOH P 4 .   ? -14.034 17.804  6.837   1    55.77  ? 667 HOH B O   1 
HETATM 9193 O  O   . HOH P 4 .   ? -3.652  20.691  10.704  1    62.34  ? 668 HOH B O   1 
HETATM 9194 O  O   . HOH P 4 .   ? -20.281 -13.446 -3.578  1    43.16  ? 669 HOH B O   1 
HETATM 9195 O  O   . HOH P 4 .   ? -23.01  -2.183  -1.862  1    36.55  ? 670 HOH B O   1 
HETATM 9196 O  O   . HOH P 4 .   ? -14.019 -21.743 -12.166 1    54.03  ? 671 HOH B O   1 
HETATM 9197 O  O   . HOH P 4 .   ? -21.314 -1.643  -26.854 1    58.08  ? 672 HOH B O   1 
HETATM 9198 O  O   . HOH P 4 .   ? -35.104 -3.65   -1.799  1    47.17  ? 673 HOH B O   1 
HETATM 9199 O  O   . HOH P 4 .   ? -7.248  -21.028 -10.222 1    48.25  ? 674 HOH B O   1 
HETATM 9200 O  O   . HOH P 4 .   ? -33.411 7.769   1.509   1    58.42  ? 675 HOH B O   1 
HETATM 9201 O  O   . HOH P 4 .   ? -36.173 4.69    8.153   1    57.8   ? 676 HOH B O   1 
HETATM 9202 O  O   . HOH P 4 .   ? -33.766 -12.893 3.354   1    50.76  ? 677 HOH B O   1 
HETATM 9203 O  O   . HOH P 4 .   ? -24.743 9.069   -8.719  1    47.44  ? 678 HOH B O   1 
HETATM 9204 O  O   . HOH P 4 .   ? -13.637 -5.545  -5.588  1    39.89  ? 679 HOH B O   1 
HETATM 9205 O  O   . HOH P 4 .   ? -2.408  12.096  16.713  1    68.07  ? 680 HOH B O   1 
HETATM 9206 O  O   . HOH P 4 .   ? -7.659  18.16   15.061  1    64.24  ? 681 HOH B O   1 
HETATM 9207 O  O   . HOH P 4 .   ? -19.7   -6.191  -26.521 1    57.47  ? 682 HOH B O   1 
HETATM 9208 O  O   . HOH P 4 .   ? -24.008 8.265   -18.561 1    57.7   ? 683 HOH B O   1 
HETATM 9209 O  O   . HOH P 4 .   ? -13.606 19.263  13.066  1    47.65  ? 684 HOH B O   1 
HETATM 9210 O  O   . HOH P 4 .   ? -19.472 10.11   -8.681  1    48.02  ? 685 HOH B O   1 
HETATM 9211 O  O   . HOH P 4 .   ? -12.194 -22.674 -10.762 1    47.11  ? 686 HOH B O   1 
HETATM 9212 O  O   . HOH P 4 .   ? -38.397 -11.32  -15.564 1    44.74  ? 687 HOH B O   1 
HETATM 9213 O  O   . HOH P 4 .   ? -22.123 10.52   -8.783  1    41.04  ? 688 HOH B O   1 
HETATM 9214 O  O   . HOH P 4 .   ? -0.625  -3.486  4.576   1    51.96  ? 689 HOH B O   1 
HETATM 9215 O  O   . HOH P 4 .   ? -30.327 -21.105 -11.931 1    53.2   ? 690 HOH B O   1 
HETATM 9216 O  O   . HOH P 4 .   ? -25.646 3.913   18.733  1    43.31  ? 691 HOH B O   1 
HETATM 9217 O  O   . HOH P 4 .   ? -31.497 -18.186 -18.568 1    41.67  ? 692 HOH B O   1 
HETATM 9218 O  O   . HOH P 4 .   ? -27.773 2.077   -1.157  1    46.61  ? 693 HOH B O   1 
HETATM 9219 O  O   . HOH P 4 .   ? -32.872 17.033  8.12    1    57.92  ? 694 HOH B O   1 
HETATM 9220 O  O   . HOH P 4 .   ? -15.235 -27.624 -8.6    1    60.6   ? 695 HOH B O   1 
HETATM 9221 O  O   . HOH P 4 .   ? -10.273 -7.278  -8.581  1    62.98  ? 696 HOH B O   1 
HETATM 9222 O  O   . HOH P 4 .   ? -29.703 -13.114 -20.987 1    56.95  ? 697 HOH B O   1 
HETATM 9223 O  O   . HOH P 4 .   ? -15.856 -10.05  -23.183 1    57.57  ? 698 HOH B O   1 
HETATM 9224 O  O   . HOH P 4 .   ? -41.028 -14.806 -8.395  1    57.86  ? 699 HOH B O   1 
HETATM 9225 O  O   . HOH P 4 .   ? -7.172  -1.375  -7.749  1    57.64  ? 700 HOH B O   1 
HETATM 9226 O  O   . HOH P 4 .   ? -33.009 -20.642 -18.227 1    62.85  ? 701 HOH B O   1 
HETATM 9227 O  O   . HOH P 4 .   ? -6.395  -6.7    -2.106  1    46.47  ? 702 HOH B O   1 
HETATM 9228 O  O   . HOH P 4 .   ? -11.524 18.175  13.968  1    54.47  ? 703 HOH B O   1 
HETATM 9229 O  O   . HOH P 4 .   ? -35.801 -4.192  1.843   1    58.82  ? 704 HOH B O   1 
HETATM 9230 O  O   . HOH P 4 .   ? -26.496 16.187  -8.561  1    57.22  ? 705 HOH B O   1 
HETATM 9231 O  O   . HOH P 4 .   ? -27.099 -26.053 -1.816  1    50.49  ? 706 HOH B O   1 
HETATM 9232 O  O   . HOH P 4 .   ? -30.316 9.037   12.694  1    55.91  ? 707 HOH B O   1 
HETATM 9233 O  O   . HOH P 4 .   ? -23.591 20.281  0.217   1    50.67  ? 708 HOH B O   1 
HETATM 9234 O  O   . HOH P 4 .   ? -18.82  -15.439 -16.486 1    51.98  ? 709 HOH B O   1 
HETATM 9235 O  O   . HOH P 4 .   ? -6.857  17.006  -0.929  1    65.41  ? 710 HOH B O   1 
HETATM 9236 O  O   . HOH P 4 .   ? -27.531 -1.075  -0.811  1    41.24  ? 711 HOH B O   1 
HETATM 9237 O  O   . HOH P 4 .   ? -31.452 16.326  5.275   1    52.76  ? 712 HOH B O   1 
HETATM 9238 O  O   . HOH P 4 .   ? -27.562 -13.18  -19.369 1    52.13  ? 713 HOH B O   1 
HETATM 9239 O  O   . HOH P 4 .   ? -39.032 -10.621 -5.181  1    57.62  ? 714 HOH B O   1 
HETATM 9240 O  O   . HOH P 4 .   ? -35.821 6.799   0.177   1    72.57  ? 715 HOH B O   1 
HETATM 9241 O  O   . HOH P 4 .   ? -24.586 9.909   -11.246 1    44.21  ? 716 HOH B O   1 
HETATM 9242 O  O   . HOH P 4 .   ? -27.664 -1.892  1.939   1    46.35  ? 717 HOH B O   1 
HETATM 9243 O  O   . HOH P 4 .   ? -16.14  -11.549 -10.952 1    41.71  ? 718 HOH B O   1 
HETATM 9244 O  O   . HOH P 4 .   ? -36.242 -6.007  -1.906  1    39.5   ? 719 HOH B O   1 
HETATM 9245 O  O   . HOH P 4 .   ? -25.058 -0.378  -1.747  1    39.99  ? 720 HOH B O   1 
HETATM 9246 O  O   . HOH Q 4 .   ? -36.299 4.814   22.632  1    64.65  ? 601 HOH C O   1 
HETATM 9247 O  O   . HOH Q 4 .   ? -17.086 8.683   40.466  1    61.92  ? 602 HOH C O   1 
HETATM 9248 O  O   . HOH Q 4 .   ? -18.429 4.083   26.058  1    55.85  ? 603 HOH C O   1 
HETATM 9249 O  O   . HOH Q 4 .   ? -22.928 10.956  17.85   1    45.98  ? 604 HOH C O   1 
HETATM 9250 O  O   . HOH Q 4 .   ? -44.646 24.045  17.012  1    72.34  ? 605 HOH C O   1 
HETATM 9251 O  O   . HOH Q 4 .   ? -43.838 6.74    43.717  1    52.81  ? 606 HOH C O   1 
HETATM 9252 O  O   . HOH Q 4 .   ? -29.034 13.407  19.047  1    53.14  ? 607 HOH C O   1 
HETATM 9253 O  O   . HOH Q 4 .   ? -28.786 15.502  20.801  1    56.16  ? 608 HOH C O   1 
HETATM 9254 O  O   . HOH Q 4 .   ? -14.642 11.009  37.603  1    56.86  ? 609 HOH C O   1 
HETATM 9255 O  O   . HOH Q 4 .   ? -41.223 4.174   37.578  1    60.81  ? 610 HOH C O   1 
HETATM 9256 O  O   . HOH Q 4 .   ? -60.883 8.019   30.202  1    55.5   ? 611 HOH C O   1 
HETATM 9257 O  O   . HOH Q 4 .   ? -30.091 17.735  20.086  1    47.27  ? 612 HOH C O   1 
HETATM 9258 O  O   . HOH Q 4 .   ? -38.007 29.004  34.643  1    63.7   ? 613 HOH C O   1 
HETATM 9259 O  O   . HOH Q 4 .   ? -27.528 9.984   17.832  1    44.26  ? 614 HOH C O   1 
HETATM 9260 O  O   . HOH Q 4 .   ? -42.786 5.8     16.181  1    54.44  ? 615 HOH C O   1 
HETATM 9261 O  O   . HOH Q 4 .   ? -46.152 15.42   37.678  1    62.97  ? 616 HOH C O   1 
HETATM 9262 O  O   . HOH Q 4 .   ? -16.306 7.795   25.846  1    59.93  ? 617 HOH C O   1 
HETATM 9263 O  O   . HOH Q 4 .   ? -34.37  7.022   36.671  1    64.22  ? 618 HOH C O   1 
HETATM 9264 O  O   . HOH Q 4 .   ? -24.268 0.295   48.249  1    50.53  ? 619 HOH C O   1 
HETATM 9265 O  O   . HOH Q 4 .   ? -23.088 10.691  21.416  1    44.86  ? 620 HOH C O   1 
HETATM 9266 O  O   . HOH Q 4 .   ? -14.215 7.343   30.884  1    63.47  ? 621 HOH C O   1 
HETATM 9267 O  O   . HOH Q 4 .   ? -37.795 11.407  19.776  1    53.89  ? 622 HOH C O   1 
HETATM 9268 O  O   . HOH Q 4 .   ? -36.648 6.85    23.693  1    45.53  ? 623 HOH C O   1 
HETATM 9269 O  O   . HOH Q 4 .   ? -41.893 0.856   42.678  1    55.89  ? 624 HOH C O   1 
HETATM 9270 O  O   . HOH Q 4 .   ? -51.301 23.638  35.617  1    47.88  ? 625 HOH C O   1 
HETATM 9271 O  O   . HOH Q 4 .   ? -53.911 1.596   39.177  1    56.93  ? 626 HOH C O   1 
HETATM 9272 O  O   . HOH Q 4 .   ? -52.658 13.019  37.272  1    46.55  ? 627 HOH C O   1 
HETATM 9273 O  O   . HOH Q 4 .   ? -50.047 10.605  45.758  1    56.19  ? 628 HOH C O   1 
HETATM 9274 O  O   . HOH Q 4 .   ? -51.103 25.24   15.527  1    68.85  ? 629 HOH C O   1 
HETATM 9275 O  O   . HOH Q 4 .   ? -42.238 9.09    34.68   1    39.37  ? 630 HOH C O   1 
HETATM 9276 O  O   . HOH Q 4 .   ? -53.016 -6.199  35.503  1    64.7   ? 631 HOH C O   1 
HETATM 9277 O  O   . HOH Q 4 .   ? -52.173 22.594  38.109  1    43.65  ? 632 HOH C O   1 
HETATM 9278 O  O   . HOH Q 4 .   ? -38.151 8.224   21.471  1    58.12  ? 633 HOH C O   1 
HETATM 9279 O  O   . HOH Q 4 .   ? -42.342 20.207  40.097  1    52.57  ? 634 HOH C O   1 
HETATM 9280 O  O   . HOH Q 4 .   ? -15.46  16.253  30.382  1    57     ? 635 HOH C O   1 
HETATM 9281 O  O   . HOH Q 4 .   ? -43.334 -1.426  34.976  1    44.41  ? 636 HOH C O   1 
HETATM 9282 O  O   . HOH Q 4 .   ? -35.245 0.072   43.917  1    50.31  ? 637 HOH C O   1 
HETATM 9283 O  O   . HOH Q 4 .   ? -56.963 27.036  42.279  1    59.27  ? 638 HOH C O   1 
HETATM 9284 O  O   . HOH Q 4 .   ? -51.785 16.751  52.38   1    69.2   ? 639 HOH C O   1 
HETATM 9285 O  O   . HOH Q 4 .   ? -52.774 3.851   44.106  1    56.1   ? 640 HOH C O   1 
HETATM 9286 O  O   . HOH Q 4 .   ? -44.951 35.357  22.09   1    69.18  ? 641 HOH C O   1 
HETATM 9287 O  O   . HOH Q 4 .   ? -18.276 0.542   45.315  1    74.52  ? 642 HOH C O   1 
HETATM 9288 O  O   . HOH Q 4 .   ? -25.884 8.55    19.532  1    49.54  ? 643 HOH C O   1 
HETATM 9289 O  O   . HOH Q 4 .   ? -38.228 19.294  15.551  1    62.49  ? 644 HOH C O   1 
HETATM 9290 O  O   . HOH Q 4 .   ? -62.499 9.291   25.017  1    61.71  ? 645 HOH C O   1 
HETATM 9291 O  O   . HOH Q 4 .   ? -43.505 5.397   46.474  1    64.87  ? 646 HOH C O   1 
HETATM 9292 O  O   . HOH Q 4 .   ? -42.723 32.184  21.47   1    69.02  ? 647 HOH C O   1 
HETATM 9293 O  O   . HOH Q 4 .   ? -23.085 0.44    25.052  1    48.61  ? 648 HOH C O   1 
HETATM 9294 O  O   . HOH Q 4 .   ? -34.539 -1.155  21.169  1    66.06  ? 649 HOH C O   1 
HETATM 9295 O  O   . HOH Q 4 .   ? -26.5   17.498  18.357  1    52.34  ? 650 HOH C O   1 
HETATM 9296 O  O   . HOH Q 4 .   ? -49.046 2.447   47.091  1    53.78  ? 651 HOH C O   1 
HETATM 9297 O  O   . HOH Q 4 .   ? -36.408 15.907  34.605  1    58.3   ? 652 HOH C O   1 
HETATM 9298 O  O   . HOH Q 4 .   ? -16.333 7.033   33.881  1    61.29  ? 653 HOH C O   1 
HETATM 9299 O  O   . HOH Q 4 .   ? -18.732 6.791   22.898  1    44.83  ? 654 HOH C O   1 
HETATM 9300 O  O   . HOH Q 4 .   ? -28.341 -1.803  27.591  1    58.2   ? 655 HOH C O   1 
HETATM 9301 O  O   . HOH Q 4 .   ? -32.02  21.463  29.033  1    49.79  ? 656 HOH C O   1 
HETATM 9302 O  O   . HOH Q 4 .   ? -40.805 4.746   40.47   1    51.91  ? 657 HOH C O   1 
HETATM 9303 O  O   . HOH Q 4 .   ? -14.555 7.42    40.895  1    59.39  ? 658 HOH C O   1 
HETATM 9304 O  O   . HOH Q 4 .   ? -14.978 17.227  33.209  1    59.21  ? 659 HOH C O   1 
HETATM 9305 O  O   . HOH Q 4 .   ? -24.214 8.344   22.131  1    50.9   ? 660 HOH C O   1 
HETATM 9306 O  O   . HOH R 4 .   ? -46.208 -31.226 32.171  1    64.92  ? 601 HOH D O   1 
HETATM 9307 O  O   . HOH R 4 .   ? -45.489 -6.871  33.764  1    54.09  ? 602 HOH D O   1 
HETATM 9308 O  O   . HOH R 4 .   ? -49.71  -5.742  29.459  1    54.9   ? 603 HOH D O   1 
HETATM 9309 O  O   . HOH R 4 .   ? -40.068 -19.122 29.624  1    59.54  ? 604 HOH D O   1 
HETATM 9310 O  O   . HOH R 4 .   ? -48.408 2.706   51.937  1    56.1   ? 605 HOH D O   1 
HETATM 9311 O  O   . HOH R 4 .   ? -32.882 -32.511 38.987  1    58.43  ? 606 HOH D O   1 
HETATM 9312 O  O   . HOH R 4 .   ? -62.038 -12.091 11.436  1    68.18  ? 607 HOH D O   1 
HETATM 9313 O  O   . HOH R 4 .   ? -40.575 -1.756  42.461  1    40.47  ? 608 HOH D O   1 
HETATM 9314 O  O   . HOH R 4 .   ? -48.172 -4.918  35.148  1    58.65  ? 609 HOH D O   1 
HETATM 9315 O  O   . HOH R 4 .   ? -43.358 -20.747 27.179  1    68.28  ? 610 HOH D O   1 
HETATM 9316 O  O   . HOH R 4 .   ? -38.194 -27.347 33.583  1    53.15  ? 611 HOH D O   1 
HETATM 9317 O  O   . HOH R 4 .   ? -42.509 -28.9   45.389  1    53.58  ? 612 HOH D O   1 
HETATM 9318 O  O   . HOH R 4 .   ? -26.823 -4.787  40.977  1    46.69  ? 613 HOH D O   1 
HETATM 9319 O  O   . HOH R 4 .   ? -45.283 -3.175  35.641  1    41.27  ? 614 HOH D O   1 
HETATM 9320 O  O   . HOH R 4 .   ? -45.98  -17.787 43.998  1    44.73  ? 615 HOH D O   1 
HETATM 9321 O  O   . HOH R 4 .   ? -43.658 -19.375 18.581  1    60.05  ? 616 HOH D O   1 
HETATM 9322 O  O   . HOH R 4 .   ? -28.125 -23.598 42.374  1    43.5   ? 617 HOH D O   1 
HETATM 9323 O  O   . HOH R 4 .   ? -19.087 -12.741 47.22   1    57.8   ? 618 HOH D O   1 
HETATM 9324 O  O   . HOH R 4 .   ? -47.733 -8.208  45.736  1    49.35  ? 619 HOH D O   1 
HETATM 9325 O  O   . HOH R 4 .   ? -35.854 -4.26   46.121  1    56.66  ? 620 HOH D O   1 
HETATM 9326 O  O   . HOH R 4 .   ? -31.175 -5.233  51.52   1    55.79  ? 621 HOH D O   1 
HETATM 9327 O  O   . HOH R 4 .   ? -40.478 -1.883  21.17   1    59.04  ? 622 HOH D O   1 
HETATM 9328 O  O   . HOH R 4 .   ? -21.183 -18.055 48.362  1    55.88  ? 623 HOH D O   1 
HETATM 9329 O  O   . HOH R 4 .   ? -21.044 -24.553 27.756  1    63.81  ? 624 HOH D O   1 
HETATM 9330 O  O   . HOH R 4 .   ? -59.548 4.836   37.116  1    65.69  ? 625 HOH D O   1 
HETATM 9331 O  O   . HOH R 4 .   ? -43.986 -6.699  31.171  1    54.42  ? 626 HOH D O   1 
HETATM 9332 O  O   . HOH R 4 .   ? -38.71  -4.114  27.916  1    43.89  ? 627 HOH D O   1 
HETATM 9333 O  O   . HOH R 4 .   ? -30.221 -11.641 54.827  1    57.35  ? 628 HOH D O   1 
HETATM 9334 O  O   . HOH R 4 .   ? -45.746 -16.228 31.455  1    44.77  ? 629 HOH D O   1 
HETATM 9335 O  O   . HOH R 4 .   ? -42.963 2.118   44.516  1    61.54  ? 630 HOH D O   1 
HETATM 9336 O  O   . HOH R 4 .   ? -45.987 -28.363 36.424  1    57.59  ? 631 HOH D O   1 
HETATM 9337 O  O   . HOH R 4 .   ? -45.13  -28.816 39.081  1    61.23  ? 632 HOH D O   1 
HETATM 9338 O  O   . HOH R 4 .   ? -32.523 -21.838 49.683  1    58.81  ? 633 HOH D O   1 
HETATM 9339 O  O   . HOH R 4 .   ? -51.248 -25.343 20.336  1    57.74  ? 634 HOH D O   1 
HETATM 9340 O  O   . HOH R 4 .   ? -53.415 -13.761 21.691  1    55.76  ? 635 HOH D O   1 
HETATM 9341 O  O   . HOH R 4 .   ? -21.761 -7.963  37.483  1    49.52  ? 636 HOH D O   1 
HETATM 9342 O  O   . HOH R 4 .   ? -47.379 -4.547  43.758  1    46.72  ? 637 HOH D O   1 
HETATM 9343 O  O   . HOH R 4 .   ? -26.704 -11.262 25.889  1    62.27  ? 638 HOH D O   1 
HETATM 9344 O  O   . HOH R 4 .   ? -38.218 -6.79   52.408  1    57.52  ? 639 HOH D O   1 
HETATM 9345 O  O   . HOH R 4 .   ? -21.663 -26.123 40.166  1    60.8   ? 640 HOH D O   1 
HETATM 9346 O  O   . HOH R 4 .   ? -40.739 1.117   45.805  1    48.33  ? 641 HOH D O   1 
HETATM 9347 O  O   . HOH R 4 .   ? -42.31  -34.84  37.749  1    53.3   ? 642 HOH D O   1 
HETATM 9348 O  O   . HOH R 4 .   ? -34.268 -19.053 54.616  1    56.1   ? 643 HOH D O   1 
HETATM 9349 O  O   . HOH R 4 .   ? -51.064 -12.234 42.834  1    66.42  ? 644 HOH D O   1 
HETATM 9350 O  O   . HOH R 4 .   ? -36.037 -30.327 26.245  1    52.33  ? 645 HOH D O   1 
HETATM 9351 O  O   . HOH R 4 .   ? -34.346 -33.368 33.086  1    61.89  ? 646 HOH D O   1 
HETATM 9352 O  O   . HOH R 4 .   ? -32.741 -11.189 25.698  1    50.65  ? 647 HOH D O   1 
HETATM 9353 O  O   . HOH R 4 .   ? -20.711 -10.482 50.53   1    61.59  ? 648 HOH D O   1 
HETATM 9354 O  O   . HOH R 4 .   ? -49.448 -7.226  34.71   1    64.03  ? 649 HOH D O   1 
HETATM 9355 O  O   . HOH R 4 .   ? -24.738 -13.229 25.905  1    63.92  ? 650 HOH D O   1 
HETATM 9356 O  O   . HOH R 4 .   ? -44.316 -18.385 29.903  1    57.17  ? 651 HOH D O   1 
# 
