data_9EL8
# 
_entry.id   9EL8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9EL8         pdb_00009el8 10.2210/pdb9el8/pdb 
WWPDB D_1000290735 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9EL8 
_pdbx_database_status.recvd_initial_deposition_date   2024-12-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              andrea.mattevi@unipv.it 
_pdbx_contact_author.name_first         Mattevi 
_pdbx_contact_author.name_last          Andrea 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-9523-7128 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Caroli, J.'  1 0000-0001-8954-8045 
'Mattevi, A.' 2 0000-0002-9523-7128 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'to be published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Caroli, J.'  1 0000-0001-8954-8045 
primary 'Mattevi, A.' 2 0000-0002-9523-7128 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Lysine-specific histone demethylase 1A' 95051.633 1 1.14.99.66 ? ? ? 
2 polymer     man 'REST corepressor 1' 16459.742 1 ?          ? ? ? 
3 non-polymer syn 
;[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2S,3R,4S)-2,3,4-trihydroxy-5-[(1R,3R,3aS,13R)-1-hydroxy-10,11-dimethyl-3-{3-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl}-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (non-preferred name)
;
1060.876  1 ?          ? ? ? 
4 non-polymer syn '3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide' 328.432   1 ?          
? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 
;BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2,[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A
;
2 'Protein CoREST' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GSSHHHHHHSSGLVPRGSHMLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPR
KKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEER
NAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLW
LDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFG
MDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQE
FNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQ
YKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANA
TPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAV
LCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAP
ILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPIT
PGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
;
;GSSHHHHHHSSGLVPRGSHMLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPR
KKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEER
NAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLW
LDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFG
MDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQE
FNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQ
YKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANA
TPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAV
LCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAP
ILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPIT
PGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
;
A ? 
2 'polypeptide(L)' no no 
;GPLGSPEFRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVI
QKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAE
;
;GPLGSPEFRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVI
QKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAE
;
B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 
;[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2S,3R,4S)-2,3,4-trihydroxy-5-[(1R,3R,3aS,13R)-1-hydroxy-10,11-dimethyl-3-{3-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl}-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (non-preferred name)
;
XHT 
4 '3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide' XHX 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   SER n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  SER n 
1 11  SER n 
1 12  GLY n 
1 13  LEU n 
1 14  VAL n 
1 15  PRO n 
1 16  ARG n 
1 17  GLY n 
1 18  SER n 
1 19  HIS n 
1 20  MET n 
1 21  LEU n 
1 22  SER n 
1 23  GLY n 
1 24  LYS n 
1 25  LYS n 
1 26  ALA n 
1 27  ALA n 
1 28  ALA n 
1 29  ALA n 
1 30  ALA n 
1 31  ALA n 
1 32  ALA n 
1 33  ALA n 
1 34  ALA n 
1 35  ALA n 
1 36  ALA n 
1 37  ALA n 
1 38  THR n 
1 39  GLY n 
1 40  THR n 
1 41  GLU n 
1 42  ALA n 
1 43  GLY n 
1 44  PRO n 
1 45  GLY n 
1 46  THR n 
1 47  ALA n 
1 48  GLY n 
1 49  GLY n 
1 50  SER n 
1 51  GLU n 
1 52  ASN n 
1 53  GLY n 
1 54  SER n 
1 55  GLU n 
1 56  VAL n 
1 57  ALA n 
1 58  ALA n 
1 59  GLN n 
1 60  PRO n 
1 61  ALA n 
1 62  GLY n 
1 63  LEU n 
1 64  SER n 
1 65  GLY n 
1 66  PRO n 
1 67  ALA n 
1 68  GLU n 
1 69  VAL n 
1 70  GLY n 
1 71  PRO n 
1 72  GLY n 
1 73  ALA n 
1 74  VAL n 
1 75  GLY n 
1 76  GLU n 
1 77  ARG n 
1 78  THR n 
1 79  PRO n 
1 80  ARG n 
1 81  LYS n 
1 82  LYS n 
1 83  GLU n 
1 84  PRO n 
1 85  PRO n 
1 86  ARG n 
1 87  ALA n 
1 88  SER n 
1 89  PRO n 
1 90  PRO n 
1 91  GLY n 
1 92  GLY n 
1 93  LEU n 
1 94  ALA n 
1 95  GLU n 
1 96  PRO n 
1 97  PRO n 
1 98  GLY n 
1 99  SER n 
1 100 ALA n 
1 101 GLY n 
1 102 PRO n 
1 103 GLN n 
1 104 ALA n 
1 105 GLY n 
1 106 PRO n 
1 107 THR n 
1 108 VAL n 
1 109 VAL n 
1 110 PRO n 
1 111 GLY n 
1 112 SER n 
1 113 ALA n 
1 114 THR n 
1 115 PRO n 
1 116 MET n 
1 117 GLU n 
1 118 THR n 
1 119 GLY n 
1 120 ILE n 
1 121 ALA n 
1 122 GLU n 
1 123 THR n 
1 124 PRO n 
1 125 GLU n 
1 126 GLY n 
1 127 ARG n 
1 128 ARG n 
1 129 THR n 
1 130 SER n 
1 131 ARG n 
1 132 ARG n 
1 133 LYS n 
1 134 ARG n 
1 135 ALA n 
1 136 LYS n 
1 137 VAL n 
1 138 GLU n 
1 139 TYR n 
1 140 ARG n 
1 141 GLU n 
1 142 MET n 
1 143 ASP n 
1 144 GLU n 
1 145 SER n 
1 146 LEU n 
1 147 ALA n 
1 148 ASN n 
1 149 LEU n 
1 150 SER n 
1 151 GLU n 
1 152 ASP n 
1 153 GLU n 
1 154 TYR n 
1 155 TYR n 
1 156 SER n 
1 157 GLU n 
1 158 GLU n 
1 159 GLU n 
1 160 ARG n 
1 161 ASN n 
1 162 ALA n 
1 163 LYS n 
1 164 ALA n 
1 165 GLU n 
1 166 LYS n 
1 167 GLU n 
1 168 LYS n 
1 169 LYS n 
1 170 LEU n 
1 171 PRO n 
1 172 PRO n 
1 173 PRO n 
1 174 PRO n 
1 175 PRO n 
1 176 GLN n 
1 177 ALA n 
1 178 PRO n 
1 179 PRO n 
1 180 GLU n 
1 181 GLU n 
1 182 GLU n 
1 183 ASN n 
1 184 GLU n 
1 185 SER n 
1 186 GLU n 
1 187 PRO n 
1 188 GLU n 
1 189 GLU n 
1 190 PRO n 
1 191 SER n 
1 192 GLY n 
1 193 VAL n 
1 194 GLU n 
1 195 GLY n 
1 196 ALA n 
1 197 ALA n 
1 198 PHE n 
1 199 GLN n 
1 200 SER n 
1 201 ARG n 
1 202 LEU n 
1 203 PRO n 
1 204 HIS n 
1 205 ASP n 
1 206 ARG n 
1 207 MET n 
1 208 THR n 
1 209 SER n 
1 210 GLN n 
1 211 GLU n 
1 212 ALA n 
1 213 ALA n 
1 214 CYS n 
1 215 PHE n 
1 216 PRO n 
1 217 ASP n 
1 218 ILE n 
1 219 ILE n 
1 220 SER n 
1 221 GLY n 
1 222 PRO n 
1 223 GLN n 
1 224 GLN n 
1 225 THR n 
1 226 GLN n 
1 227 LYS n 
1 228 VAL n 
1 229 PHE n 
1 230 LEU n 
1 231 PHE n 
1 232 ILE n 
1 233 ARG n 
1 234 ASN n 
1 235 ARG n 
1 236 THR n 
1 237 LEU n 
1 238 GLN n 
1 239 LEU n 
1 240 TRP n 
1 241 LEU n 
1 242 ASP n 
1 243 ASN n 
1 244 PRO n 
1 245 LYS n 
1 246 ILE n 
1 247 GLN n 
1 248 LEU n 
1 249 THR n 
1 250 PHE n 
1 251 GLU n 
1 252 ALA n 
1 253 THR n 
1 254 LEU n 
1 255 GLN n 
1 256 GLN n 
1 257 LEU n 
1 258 GLU n 
1 259 ALA n 
1 260 PRO n 
1 261 TYR n 
1 262 ASN n 
1 263 SER n 
1 264 ASP n 
1 265 THR n 
1 266 VAL n 
1 267 LEU n 
1 268 VAL n 
1 269 HIS n 
1 270 ARG n 
1 271 VAL n 
1 272 HIS n 
1 273 SER n 
1 274 TYR n 
1 275 LEU n 
1 276 GLU n 
1 277 ARG n 
1 278 HIS n 
1 279 GLY n 
1 280 LEU n 
1 281 ILE n 
1 282 ASN n 
1 283 PHE n 
1 284 GLY n 
1 285 ILE n 
1 286 TYR n 
1 287 LYS n 
1 288 ARG n 
1 289 ILE n 
1 290 LYS n 
1 291 PRO n 
1 292 LEU n 
1 293 PRO n 
1 294 THR n 
1 295 LYS n 
1 296 LYS n 
1 297 THR n 
1 298 GLY n 
1 299 LYS n 
1 300 VAL n 
1 301 ILE n 
1 302 ILE n 
1 303 ILE n 
1 304 GLY n 
1 305 SER n 
1 306 GLY n 
1 307 VAL n 
1 308 SER n 
1 309 GLY n 
1 310 LEU n 
1 311 ALA n 
1 312 ALA n 
1 313 ALA n 
1 314 ARG n 
1 315 GLN n 
1 316 LEU n 
1 317 GLN n 
1 318 SER n 
1 319 PHE n 
1 320 GLY n 
1 321 MET n 
1 322 ASP n 
1 323 VAL n 
1 324 THR n 
1 325 LEU n 
1 326 LEU n 
1 327 GLU n 
1 328 ALA n 
1 329 ARG n 
1 330 ASP n 
1 331 ARG n 
1 332 VAL n 
1 333 GLY n 
1 334 GLY n 
1 335 ARG n 
1 336 VAL n 
1 337 ALA n 
1 338 THR n 
1 339 PHE n 
1 340 ARG n 
1 341 LYS n 
1 342 GLY n 
1 343 ASN n 
1 344 TYR n 
1 345 VAL n 
1 346 ALA n 
1 347 ASP n 
1 348 LEU n 
1 349 GLY n 
1 350 ALA n 
1 351 MET n 
1 352 VAL n 
1 353 VAL n 
1 354 THR n 
1 355 GLY n 
1 356 LEU n 
1 357 GLY n 
1 358 GLY n 
1 359 ASN n 
1 360 PRO n 
1 361 MET n 
1 362 ALA n 
1 363 VAL n 
1 364 VAL n 
1 365 SER n 
1 366 LYS n 
1 367 GLN n 
1 368 VAL n 
1 369 ASN n 
1 370 MET n 
1 371 GLU n 
1 372 LEU n 
1 373 ALA n 
1 374 LYS n 
1 375 ILE n 
1 376 LYS n 
1 377 GLN n 
1 378 LYS n 
1 379 CYS n 
1 380 PRO n 
1 381 LEU n 
1 382 TYR n 
1 383 GLU n 
1 384 ALA n 
1 385 ASN n 
1 386 GLY n 
1 387 GLN n 
1 388 ALA n 
1 389 VAL n 
1 390 PRO n 
1 391 LYS n 
1 392 GLU n 
1 393 LYS n 
1 394 ASP n 
1 395 GLU n 
1 396 MET n 
1 397 VAL n 
1 398 GLU n 
1 399 GLN n 
1 400 GLU n 
1 401 PHE n 
1 402 ASN n 
1 403 ARG n 
1 404 LEU n 
1 405 LEU n 
1 406 GLU n 
1 407 ALA n 
1 408 THR n 
1 409 SER n 
1 410 TYR n 
1 411 LEU n 
1 412 SER n 
1 413 HIS n 
1 414 GLN n 
1 415 LEU n 
1 416 ASP n 
1 417 PHE n 
1 418 ASN n 
1 419 VAL n 
1 420 LEU n 
1 421 ASN n 
1 422 ASN n 
1 423 LYS n 
1 424 PRO n 
1 425 VAL n 
1 426 SER n 
1 427 LEU n 
1 428 GLY n 
1 429 GLN n 
1 430 ALA n 
1 431 LEU n 
1 432 GLU n 
1 433 VAL n 
1 434 VAL n 
1 435 ILE n 
1 436 GLN n 
1 437 LEU n 
1 438 GLN n 
1 439 GLU n 
1 440 LYS n 
1 441 HIS n 
1 442 VAL n 
1 443 LYS n 
1 444 ASP n 
1 445 GLU n 
1 446 GLN n 
1 447 ILE n 
1 448 GLU n 
1 449 HIS n 
1 450 TRP n 
1 451 LYS n 
1 452 LYS n 
1 453 ILE n 
1 454 VAL n 
1 455 LYS n 
1 456 THR n 
1 457 GLN n 
1 458 GLU n 
1 459 GLU n 
1 460 LEU n 
1 461 LYS n 
1 462 GLU n 
1 463 LEU n 
1 464 LEU n 
1 465 ASN n 
1 466 LYS n 
1 467 MET n 
1 468 VAL n 
1 469 ASN n 
1 470 LEU n 
1 471 LYS n 
1 472 GLU n 
1 473 LYS n 
1 474 ILE n 
1 475 LYS n 
1 476 GLU n 
1 477 LEU n 
1 478 HIS n 
1 479 GLN n 
1 480 GLN n 
1 481 TYR n 
1 482 LYS n 
1 483 GLU n 
1 484 ALA n 
1 485 SER n 
1 486 GLU n 
1 487 VAL n 
1 488 LYS n 
1 489 PRO n 
1 490 PRO n 
1 491 ARG n 
1 492 ASP n 
1 493 ILE n 
1 494 THR n 
1 495 ALA n 
1 496 GLU n 
1 497 PHE n 
1 498 LEU n 
1 499 VAL n 
1 500 LYS n 
1 501 SER n 
1 502 LYS n 
1 503 HIS n 
1 504 ARG n 
1 505 ASP n 
1 506 LEU n 
1 507 THR n 
1 508 ALA n 
1 509 LEU n 
1 510 CYS n 
1 511 LYS n 
1 512 GLU n 
1 513 TYR n 
1 514 ASP n 
1 515 GLU n 
1 516 LEU n 
1 517 ALA n 
1 518 GLU n 
1 519 THR n 
1 520 GLN n 
1 521 GLY n 
1 522 LYS n 
1 523 LEU n 
1 524 GLU n 
1 525 GLU n 
1 526 LYS n 
1 527 LEU n 
1 528 GLN n 
1 529 GLU n 
1 530 LEU n 
1 531 GLU n 
1 532 ALA n 
1 533 ASN n 
1 534 PRO n 
1 535 PRO n 
1 536 SER n 
1 537 ASP n 
1 538 VAL n 
1 539 TYR n 
1 540 LEU n 
1 541 SER n 
1 542 SER n 
1 543 ARG n 
1 544 ASP n 
1 545 ARG n 
1 546 GLN n 
1 547 ILE n 
1 548 LEU n 
1 549 ASP n 
1 550 TRP n 
1 551 HIS n 
1 552 PHE n 
1 553 ALA n 
1 554 ASN n 
1 555 LEU n 
1 556 GLU n 
1 557 PHE n 
1 558 ALA n 
1 559 ASN n 
1 560 ALA n 
1 561 THR n 
1 562 PRO n 
1 563 LEU n 
1 564 SER n 
1 565 THR n 
1 566 LEU n 
1 567 SER n 
1 568 LEU n 
1 569 LYS n 
1 570 HIS n 
1 571 TRP n 
1 572 ASP n 
1 573 GLN n 
1 574 ASP n 
1 575 ASP n 
1 576 ASP n 
1 577 PHE n 
1 578 GLU n 
1 579 PHE n 
1 580 THR n 
1 581 GLY n 
1 582 SER n 
1 583 HIS n 
1 584 LEU n 
1 585 THR n 
1 586 VAL n 
1 587 ARG n 
1 588 ASN n 
1 589 GLY n 
1 590 TYR n 
1 591 SER n 
1 592 CYS n 
1 593 VAL n 
1 594 PRO n 
1 595 VAL n 
1 596 ALA n 
1 597 LEU n 
1 598 ALA n 
1 599 GLU n 
1 600 GLY n 
1 601 LEU n 
1 602 ASP n 
1 603 ILE n 
1 604 LYS n 
1 605 LEU n 
1 606 ASN n 
1 607 THR n 
1 608 ALA n 
1 609 VAL n 
1 610 ARG n 
1 611 GLN n 
1 612 VAL n 
1 613 ARG n 
1 614 TYR n 
1 615 THR n 
1 616 ALA n 
1 617 SER n 
1 618 GLY n 
1 619 CYS n 
1 620 GLU n 
1 621 VAL n 
1 622 ILE n 
1 623 ALA n 
1 624 VAL n 
1 625 ASN n 
1 626 THR n 
1 627 ARG n 
1 628 SER n 
1 629 THR n 
1 630 SER n 
1 631 GLN n 
1 632 THR n 
1 633 PHE n 
1 634 ILE n 
1 635 TYR n 
1 636 LYS n 
1 637 CYS n 
1 638 ASP n 
1 639 ALA n 
1 640 VAL n 
1 641 LEU n 
1 642 CYS n 
1 643 THR n 
1 644 LEU n 
1 645 PRO n 
1 646 LEU n 
1 647 GLY n 
1 648 VAL n 
1 649 LEU n 
1 650 LYS n 
1 651 GLN n 
1 652 GLN n 
1 653 PRO n 
1 654 PRO n 
1 655 ALA n 
1 656 VAL n 
1 657 GLN n 
1 658 PHE n 
1 659 VAL n 
1 660 PRO n 
1 661 PRO n 
1 662 LEU n 
1 663 PRO n 
1 664 GLU n 
1 665 TRP n 
1 666 LYS n 
1 667 THR n 
1 668 SER n 
1 669 ALA n 
1 670 VAL n 
1 671 GLN n 
1 672 ARG n 
1 673 MET n 
1 674 GLY n 
1 675 PHE n 
1 676 GLY n 
1 677 ASN n 
1 678 LEU n 
1 679 ASN n 
1 680 LYS n 
1 681 VAL n 
1 682 VAL n 
1 683 LEU n 
1 684 CYS n 
1 685 PHE n 
1 686 ASP n 
1 687 ARG n 
1 688 VAL n 
1 689 PHE n 
1 690 TRP n 
1 691 ASP n 
1 692 PRO n 
1 693 SER n 
1 694 VAL n 
1 695 ASN n 
1 696 LEU n 
1 697 PHE n 
1 698 GLY n 
1 699 HIS n 
1 700 VAL n 
1 701 GLY n 
1 702 SER n 
1 703 THR n 
1 704 THR n 
1 705 ALA n 
1 706 SER n 
1 707 ARG n 
1 708 GLY n 
1 709 GLU n 
1 710 LEU n 
1 711 PHE n 
1 712 LEU n 
1 713 PHE n 
1 714 TRP n 
1 715 ASN n 
1 716 LEU n 
1 717 TYR n 
1 718 LYS n 
1 719 ALA n 
1 720 PRO n 
1 721 ILE n 
1 722 LEU n 
1 723 LEU n 
1 724 ALA n 
1 725 LEU n 
1 726 VAL n 
1 727 ALA n 
1 728 GLY n 
1 729 GLU n 
1 730 ALA n 
1 731 ALA n 
1 732 GLY n 
1 733 ILE n 
1 734 MET n 
1 735 GLU n 
1 736 ASN n 
1 737 ILE n 
1 738 SER n 
1 739 ASP n 
1 740 ASP n 
1 741 VAL n 
1 742 ILE n 
1 743 VAL n 
1 744 GLY n 
1 745 ARG n 
1 746 CYS n 
1 747 LEU n 
1 748 ALA n 
1 749 ILE n 
1 750 LEU n 
1 751 LYS n 
1 752 GLY n 
1 753 ILE n 
1 754 PHE n 
1 755 GLY n 
1 756 SER n 
1 757 SER n 
1 758 ALA n 
1 759 VAL n 
1 760 PRO n 
1 761 GLN n 
1 762 PRO n 
1 763 LYS n 
1 764 GLU n 
1 765 THR n 
1 766 VAL n 
1 767 VAL n 
1 768 SER n 
1 769 ARG n 
1 770 TRP n 
1 771 ARG n 
1 772 ALA n 
1 773 ASP n 
1 774 PRO n 
1 775 TRP n 
1 776 ALA n 
1 777 ARG n 
1 778 GLY n 
1 779 SER n 
1 780 TYR n 
1 781 SER n 
1 782 TYR n 
1 783 VAL n 
1 784 ALA n 
1 785 ALA n 
1 786 GLY n 
1 787 SER n 
1 788 SER n 
1 789 GLY n 
1 790 ASN n 
1 791 ASP n 
1 792 TYR n 
1 793 ASP n 
1 794 LEU n 
1 795 MET n 
1 796 ALA n 
1 797 GLN n 
1 798 PRO n 
1 799 ILE n 
1 800 THR n 
1 801 PRO n 
1 802 GLY n 
1 803 PRO n 
1 804 SER n 
1 805 ILE n 
1 806 PRO n 
1 807 GLY n 
1 808 ALA n 
1 809 PRO n 
1 810 GLN n 
1 811 PRO n 
1 812 ILE n 
1 813 PRO n 
1 814 ARG n 
1 815 LEU n 
1 816 PHE n 
1 817 PHE n 
1 818 ALA n 
1 819 GLY n 
1 820 GLU n 
1 821 HIS n 
1 822 THR n 
1 823 ILE n 
1 824 ARG n 
1 825 ASN n 
1 826 TYR n 
1 827 PRO n 
1 828 ALA n 
1 829 THR n 
1 830 VAL n 
1 831 HIS n 
1 832 GLY n 
1 833 ALA n 
1 834 LEU n 
1 835 LEU n 
1 836 SER n 
1 837 GLY n 
1 838 LEU n 
1 839 ARG n 
1 840 GLU n 
1 841 ALA n 
1 842 GLY n 
1 843 ARG n 
1 844 ILE n 
1 845 ALA n 
1 846 ASP n 
1 847 GLN n 
1 848 PHE n 
1 849 LEU n 
1 850 GLY n 
1 851 ALA n 
1 852 MET n 
1 853 TYR n 
1 854 THR n 
1 855 LEU n 
1 856 PRO n 
1 857 ARG n 
1 858 GLN n 
1 859 ALA n 
1 860 THR n 
1 861 PRO n 
1 862 GLY n 
1 863 VAL n 
1 864 PRO n 
1 865 ALA n 
1 866 GLN n 
1 867 GLN n 
1 868 SER n 
1 869 PRO n 
1 870 SER n 
1 871 MET n 
2 1   GLY n 
2 2   PRO n 
2 3   LEU n 
2 4   GLY n 
2 5   SER n 
2 6   PRO n 
2 7   GLU n 
2 8   PHE n 
2 9   ARG n 
2 10  ALA n 
2 11  LYS n 
2 12  ARG n 
2 13  LYS n 
2 14  PRO n 
2 15  PRO n 
2 16  LYS n 
2 17  GLY n 
2 18  MET n 
2 19  PHE n 
2 20  LEU n 
2 21  SER n 
2 22  GLN n 
2 23  GLU n 
2 24  ASP n 
2 25  VAL n 
2 26  GLU n 
2 27  ALA n 
2 28  VAL n 
2 29  SER n 
2 30  ALA n 
2 31  ASN n 
2 32  ALA n 
2 33  THR n 
2 34  ALA n 
2 35  ALA n 
2 36  THR n 
2 37  THR n 
2 38  VAL n 
2 39  LEU n 
2 40  ARG n 
2 41  GLN n 
2 42  LEU n 
2 43  ASP n 
2 44  MET n 
2 45  GLU n 
2 46  LEU n 
2 47  VAL n 
2 48  SER n 
2 49  VAL n 
2 50  LYS n 
2 51  ARG n 
2 52  GLN n 
2 53  ILE n 
2 54  GLN n 
2 55  ASN n 
2 56  ILE n 
2 57  LYS n 
2 58  GLN n 
2 59  THR n 
2 60  ASN n 
2 61  SER n 
2 62  ALA n 
2 63  LEU n 
2 64  LYS n 
2 65  GLU n 
2 66  LYS n 
2 67  LEU n 
2 68  ASP n 
2 69  GLY n 
2 70  GLY n 
2 71  ILE n 
2 72  GLU n 
2 73  PRO n 
2 74  TYR n 
2 75  ARG n 
2 76  LEU n 
2 77  PRO n 
2 78  GLU n 
2 79  VAL n 
2 80  ILE n 
2 81  GLN n 
2 82  LYS n 
2 83  CYS n 
2 84  ASN n 
2 85  ALA n 
2 86  ARG n 
2 87  TRP n 
2 88  THR n 
2 89  THR n 
2 90  GLU n 
2 91  GLU n 
2 92  GLN n 
2 93  LEU n 
2 94  LEU n 
2 95  ALA n 
2 96  VAL n 
2 97  GLN n 
2 98  ALA n 
2 99  ILE n 
2 100 ARG n 
2 101 LYS n 
2 102 TYR n 
2 103 GLY n 
2 104 ARG n 
2 105 ASP n 
2 106 PHE n 
2 107 GLN n 
2 108 ALA n 
2 109 ILE n 
2 110 SER n 
2 111 ASP n 
2 112 VAL n 
2 113 ILE n 
2 114 GLY n 
2 115 ASN n 
2 116 LYS n 
2 117 SER n 
2 118 VAL n 
2 119 VAL n 
2 120 GLN n 
2 121 VAL n 
2 122 LYS n 
2 123 ASN n 
2 124 PHE n 
2 125 PHE n 
2 126 VAL n 
2 127 ASN n 
2 128 TYR n 
2 129 ARG n 
2 130 ARG n 
2 131 ARG n 
2 132 PHE n 
2 133 ASN n 
2 134 ILE n 
2 135 ASP n 
2 136 GLU n 
2 137 VAL n 
2 138 LEU n 
2 139 GLN n 
2 140 GLU n 
2 141 TRP n 
2 142 GLU n 
2 143 ALA n 
2 144 GLU n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 871 human ? 'KDM1A, AOF2, KDM1, KIAA0601, LSD1' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 144 human ? 'RCOR1, KIAA0071, RCOR'             ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'           89.093   
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'       175.209  
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'          132.118  
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'           133.103  
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'         121.158  
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'         146.144  
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'           147.129  
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'           75.067   
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'       156.162  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'          131.173  
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'          131.173  
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'       147.195  
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'        149.211  
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'          165.189  
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'           115.130  
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'           105.093  
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'           119.119  
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'        204.225  
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'          181.189  
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'          117.146  
XHT non-polymer         . 
;[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2S,3R,4S)-2,3,4-trihydroxy-5-[(1R,3R,3aS,13R)-1-hydroxy-10,11-dimethyl-3-{3-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl}-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (non-preferred name)
;
? 'C40 H46 N12 O17 P2 S' 1060.876 
XHX non-polymer         . '3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide' ? 
'C17 H20 N4 O S'       328.432  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -18 ?   ?   ?   A . n 
A 1 2   SER 2   -17 ?   ?   ?   A . n 
A 1 3   SER 3   -16 ?   ?   ?   A . n 
A 1 4   HIS 4   -15 ?   ?   ?   A . n 
A 1 5   HIS 5   -14 ?   ?   ?   A . n 
A 1 6   HIS 6   -13 ?   ?   ?   A . n 
A 1 7   HIS 7   -12 ?   ?   ?   A . n 
A 1 8   HIS 8   -11 ?   ?   ?   A . n 
A 1 9   HIS 9   -10 ?   ?   ?   A . n 
A 1 10  SER 10  -9  ?   ?   ?   A . n 
A 1 11  SER 11  -8  ?   ?   ?   A . n 
A 1 12  GLY 12  -7  ?   ?   ?   A . n 
A 1 13  LEU 13  -6  ?   ?   ?   A . n 
A 1 14  VAL 14  -5  ?   ?   ?   A . n 
A 1 15  PRO 15  -4  ?   ?   ?   A . n 
A 1 16  ARG 16  -3  ?   ?   ?   A . n 
A 1 17  GLY 17  -2  ?   ?   ?   A . n 
A 1 18  SER 18  -1  ?   ?   ?   A . n 
A 1 19  HIS 19  0   ?   ?   ?   A . n 
A 1 20  MET 20  1   ?   ?   ?   A . n 
A 1 21  LEU 21  2   ?   ?   ?   A . n 
A 1 22  SER 22  3   ?   ?   ?   A . n 
A 1 23  GLY 23  4   ?   ?   ?   A . n 
A 1 24  LYS 24  5   ?   ?   ?   A . n 
A 1 25  LYS 25  6   ?   ?   ?   A . n 
A 1 26  ALA 26  7   ?   ?   ?   A . n 
A 1 27  ALA 27  8   ?   ?   ?   A . n 
A 1 28  ALA 28  9   ?   ?   ?   A . n 
A 1 29  ALA 29  10  ?   ?   ?   A . n 
A 1 30  ALA 30  11  ?   ?   ?   A . n 
A 1 31  ALA 31  12  ?   ?   ?   A . n 
A 1 32  ALA 32  13  ?   ?   ?   A . n 
A 1 33  ALA 33  14  ?   ?   ?   A . n 
A 1 34  ALA 34  15  ?   ?   ?   A . n 
A 1 35  ALA 35  16  ?   ?   ?   A . n 
A 1 36  ALA 36  17  ?   ?   ?   A . n 
A 1 37  ALA 37  18  ?   ?   ?   A . n 
A 1 38  THR 38  19  ?   ?   ?   A . n 
A 1 39  GLY 39  20  ?   ?   ?   A . n 
A 1 40  THR 40  21  ?   ?   ?   A . n 
A 1 41  GLU 41  22  ?   ?   ?   A . n 
A 1 42  ALA 42  23  ?   ?   ?   A . n 
A 1 43  GLY 43  24  ?   ?   ?   A . n 
A 1 44  PRO 44  25  ?   ?   ?   A . n 
A 1 45  GLY 45  26  ?   ?   ?   A . n 
A 1 46  THR 46  27  ?   ?   ?   A . n 
A 1 47  ALA 47  28  ?   ?   ?   A . n 
A 1 48  GLY 48  29  ?   ?   ?   A . n 
A 1 49  GLY 49  30  ?   ?   ?   A . n 
A 1 50  SER 50  31  ?   ?   ?   A . n 
A 1 51  GLU 51  32  ?   ?   ?   A . n 
A 1 52  ASN 52  33  ?   ?   ?   A . n 
A 1 53  GLY 53  34  ?   ?   ?   A . n 
A 1 54  SER 54  35  ?   ?   ?   A . n 
A 1 55  GLU 55  36  ?   ?   ?   A . n 
A 1 56  VAL 56  37  ?   ?   ?   A . n 
A 1 57  ALA 57  38  ?   ?   ?   A . n 
A 1 58  ALA 58  39  ?   ?   ?   A . n 
A 1 59  GLN 59  40  ?   ?   ?   A . n 
A 1 60  PRO 60  41  ?   ?   ?   A . n 
A 1 61  ALA 61  42  ?   ?   ?   A . n 
A 1 62  GLY 62  43  ?   ?   ?   A . n 
A 1 63  LEU 63  44  ?   ?   ?   A . n 
A 1 64  SER 64  45  ?   ?   ?   A . n 
A 1 65  GLY 65  46  ?   ?   ?   A . n 
A 1 66  PRO 66  47  ?   ?   ?   A . n 
A 1 67  ALA 67  48  ?   ?   ?   A . n 
A 1 68  GLU 68  49  ?   ?   ?   A . n 
A 1 69  VAL 69  50  ?   ?   ?   A . n 
A 1 70  GLY 70  51  ?   ?   ?   A . n 
A 1 71  PRO 71  52  ?   ?   ?   A . n 
A 1 72  GLY 72  53  ?   ?   ?   A . n 
A 1 73  ALA 73  54  ?   ?   ?   A . n 
A 1 74  VAL 74  55  ?   ?   ?   A . n 
A 1 75  GLY 75  56  ?   ?   ?   A . n 
A 1 76  GLU 76  57  ?   ?   ?   A . n 
A 1 77  ARG 77  58  ?   ?   ?   A . n 
A 1 78  THR 78  59  ?   ?   ?   A . n 
A 1 79  PRO 79  60  ?   ?   ?   A . n 
A 1 80  ARG 80  61  ?   ?   ?   A . n 
A 1 81  LYS 81  62  ?   ?   ?   A . n 
A 1 82  LYS 82  63  ?   ?   ?   A . n 
A 1 83  GLU 83  64  ?   ?   ?   A . n 
A 1 84  PRO 84  65  ?   ?   ?   A . n 
A 1 85  PRO 85  66  ?   ?   ?   A . n 
A 1 86  ARG 86  67  ?   ?   ?   A . n 
A 1 87  ALA 87  68  ?   ?   ?   A . n 
A 1 88  SER 88  69  ?   ?   ?   A . n 
A 1 89  PRO 89  70  ?   ?   ?   A . n 
A 1 90  PRO 90  71  ?   ?   ?   A . n 
A 1 91  GLY 91  72  ?   ?   ?   A . n 
A 1 92  GLY 92  73  ?   ?   ?   A . n 
A 1 93  LEU 93  74  ?   ?   ?   A . n 
A 1 94  ALA 94  75  ?   ?   ?   A . n 
A 1 95  GLU 95  76  ?   ?   ?   A . n 
A 1 96  PRO 96  77  ?   ?   ?   A . n 
A 1 97  PRO 97  78  ?   ?   ?   A . n 
A 1 98  GLY 98  79  ?   ?   ?   A . n 
A 1 99  SER 99  80  ?   ?   ?   A . n 
A 1 100 ALA 100 81  ?   ?   ?   A . n 
A 1 101 GLY 101 82  ?   ?   ?   A . n 
A 1 102 PRO 102 83  ?   ?   ?   A . n 
A 1 103 GLN 103 84  ?   ?   ?   A . n 
A 1 104 ALA 104 85  ?   ?   ?   A . n 
A 1 105 GLY 105 86  ?   ?   ?   A . n 
A 1 106 PRO 106 87  ?   ?   ?   A . n 
A 1 107 THR 107 88  ?   ?   ?   A . n 
A 1 108 VAL 108 89  ?   ?   ?   A . n 
A 1 109 VAL 109 90  ?   ?   ?   A . n 
A 1 110 PRO 110 91  ?   ?   ?   A . n 
A 1 111 GLY 111 92  ?   ?   ?   A . n 
A 1 112 SER 112 93  ?   ?   ?   A . n 
A 1 113 ALA 113 94  ?   ?   ?   A . n 
A 1 114 THR 114 95  ?   ?   ?   A . n 
A 1 115 PRO 115 96  ?   ?   ?   A . n 
A 1 116 MET 116 97  ?   ?   ?   A . n 
A 1 117 GLU 117 98  ?   ?   ?   A . n 
A 1 118 THR 118 99  ?   ?   ?   A . n 
A 1 119 GLY 119 100 ?   ?   ?   A . n 
A 1 120 ILE 120 101 ?   ?   ?   A . n 
A 1 121 ALA 121 102 ?   ?   ?   A . n 
A 1 122 GLU 122 103 ?   ?   ?   A . n 
A 1 123 THR 123 104 ?   ?   ?   A . n 
A 1 124 PRO 124 105 ?   ?   ?   A . n 
A 1 125 GLU 125 106 ?   ?   ?   A . n 
A 1 126 GLY 126 107 ?   ?   ?   A . n 
A 1 127 ARG 127 108 ?   ?   ?   A . n 
A 1 128 ARG 128 109 ?   ?   ?   A . n 
A 1 129 THR 129 110 ?   ?   ?   A . n 
A 1 130 SER 130 111 ?   ?   ?   A . n 
A 1 131 ARG 131 112 ?   ?   ?   A . n 
A 1 132 ARG 132 113 ?   ?   ?   A . n 
A 1 133 LYS 133 114 ?   ?   ?   A . n 
A 1 134 ARG 134 115 ?   ?   ?   A . n 
A 1 135 ALA 135 116 ?   ?   ?   A . n 
A 1 136 LYS 136 117 ?   ?   ?   A . n 
A 1 137 VAL 137 118 ?   ?   ?   A . n 
A 1 138 GLU 138 119 ?   ?   ?   A . n 
A 1 139 TYR 139 120 ?   ?   ?   A . n 
A 1 140 ARG 140 121 ?   ?   ?   A . n 
A 1 141 GLU 141 122 ?   ?   ?   A . n 
A 1 142 MET 142 123 ?   ?   ?   A . n 
A 1 143 ASP 143 124 ?   ?   ?   A . n 
A 1 144 GLU 144 125 ?   ?   ?   A . n 
A 1 145 SER 145 126 ?   ?   ?   A . n 
A 1 146 LEU 146 127 ?   ?   ?   A . n 
A 1 147 ALA 147 128 ?   ?   ?   A . n 
A 1 148 ASN 148 129 ?   ?   ?   A . n 
A 1 149 LEU 149 130 ?   ?   ?   A . n 
A 1 150 SER 150 131 ?   ?   ?   A . n 
A 1 151 GLU 151 132 ?   ?   ?   A . n 
A 1 152 ASP 152 133 ?   ?   ?   A . n 
A 1 153 GLU 153 134 ?   ?   ?   A . n 
A 1 154 TYR 154 135 ?   ?   ?   A . n 
A 1 155 TYR 155 136 ?   ?   ?   A . n 
A 1 156 SER 156 137 ?   ?   ?   A . n 
A 1 157 GLU 157 138 ?   ?   ?   A . n 
A 1 158 GLU 158 139 ?   ?   ?   A . n 
A 1 159 GLU 159 140 ?   ?   ?   A . n 
A 1 160 ARG 160 141 ?   ?   ?   A . n 
A 1 161 ASN 161 142 ?   ?   ?   A . n 
A 1 162 ALA 162 143 ?   ?   ?   A . n 
A 1 163 LYS 163 144 ?   ?   ?   A . n 
A 1 164 ALA 164 145 ?   ?   ?   A . n 
A 1 165 GLU 165 146 ?   ?   ?   A . n 
A 1 166 LYS 166 147 ?   ?   ?   A . n 
A 1 167 GLU 167 148 ?   ?   ?   A . n 
A 1 168 LYS 168 149 ?   ?   ?   A . n 
A 1 169 LYS 169 150 ?   ?   ?   A . n 
A 1 170 LEU 170 151 ?   ?   ?   A . n 
A 1 171 PRO 171 152 ?   ?   ?   A . n 
A 1 172 PRO 172 153 ?   ?   ?   A . n 
A 1 173 PRO 173 154 ?   ?   ?   A . n 
A 1 174 PRO 174 155 ?   ?   ?   A . n 
A 1 175 PRO 175 156 ?   ?   ?   A . n 
A 1 176 GLN 176 157 ?   ?   ?   A . n 
A 1 177 ALA 177 158 ?   ?   ?   A . n 
A 1 178 PRO 178 159 ?   ?   ?   A . n 
A 1 179 PRO 179 160 ?   ?   ?   A . n 
A 1 180 GLU 180 161 ?   ?   ?   A . n 
A 1 181 GLU 181 162 ?   ?   ?   A . n 
A 1 182 GLU 182 163 ?   ?   ?   A . n 
A 1 183 ASN 183 164 ?   ?   ?   A . n 
A 1 184 GLU 184 165 ?   ?   ?   A . n 
A 1 185 SER 185 166 ?   ?   ?   A . n 
A 1 186 GLU 186 167 ?   ?   ?   A . n 
A 1 187 PRO 187 168 ?   ?   ?   A . n 
A 1 188 GLU 188 169 ?   ?   ?   A . n 
A 1 189 GLU 189 170 ?   ?   ?   A . n 
A 1 190 PRO 190 171 ?   ?   ?   A . n 
A 1 191 SER 191 172 172 SER SER A . n 
A 1 192 GLY 192 173 173 GLY GLY A . n 
A 1 193 VAL 193 174 174 VAL VAL A . n 
A 1 194 GLU 194 175 175 GLU GLU A . n 
A 1 195 GLY 195 176 176 GLY GLY A . n 
A 1 196 ALA 196 177 177 ALA ALA A . n 
A 1 197 ALA 197 178 178 ALA ALA A . n 
A 1 198 PHE 198 179 179 PHE PHE A . n 
A 1 199 GLN 199 180 180 GLN GLN A . n 
A 1 200 SER 200 181 181 SER SER A . n 
A 1 201 ARG 201 182 182 ARG ARG A . n 
A 1 202 LEU 202 183 183 LEU LEU A . n 
A 1 203 PRO 203 184 184 PRO PRO A . n 
A 1 204 HIS 204 185 185 HIS HIS A . n 
A 1 205 ASP 205 186 186 ASP ASP A . n 
A 1 206 ARG 206 187 187 ARG ARG A . n 
A 1 207 MET 207 188 188 MET MET A . n 
A 1 208 THR 208 189 189 THR THR A . n 
A 1 209 SER 209 190 190 SER SER A . n 
A 1 210 GLN 210 191 191 GLN GLN A . n 
A 1 211 GLU 211 192 192 GLU GLU A . n 
A 1 212 ALA 212 193 193 ALA ALA A . n 
A 1 213 ALA 213 194 194 ALA ALA A . n 
A 1 214 CYS 214 195 195 CYS CYS A . n 
A 1 215 PHE 215 196 196 PHE PHE A . n 
A 1 216 PRO 216 197 197 PRO PRO A . n 
A 1 217 ASP 217 198 198 ASP ASP A . n 
A 1 218 ILE 218 199 199 ILE ILE A . n 
A 1 219 ILE 219 200 200 ILE ILE A . n 
A 1 220 SER 220 201 201 SER SER A . n 
A 1 221 GLY 221 202 202 GLY GLY A . n 
A 1 222 PRO 222 203 203 PRO PRO A . n 
A 1 223 GLN 223 204 204 GLN GLN A . n 
A 1 224 GLN 224 205 205 GLN GLN A . n 
A 1 225 THR 225 206 206 THR THR A . n 
A 1 226 GLN 226 207 207 GLN GLN A . n 
A 1 227 LYS 227 208 208 LYS LYS A . n 
A 1 228 VAL 228 209 209 VAL VAL A . n 
A 1 229 PHE 229 210 210 PHE PHE A . n 
A 1 230 LEU 230 211 211 LEU LEU A . n 
A 1 231 PHE 231 212 212 PHE PHE A . n 
A 1 232 ILE 232 213 213 ILE ILE A . n 
A 1 233 ARG 233 214 214 ARG ARG A . n 
A 1 234 ASN 234 215 215 ASN ASN A . n 
A 1 235 ARG 235 216 216 ARG ARG A . n 
A 1 236 THR 236 217 217 THR THR A . n 
A 1 237 LEU 237 218 218 LEU LEU A . n 
A 1 238 GLN 238 219 219 GLN GLN A . n 
A 1 239 LEU 239 220 220 LEU LEU A . n 
A 1 240 TRP 240 221 221 TRP TRP A . n 
A 1 241 LEU 241 222 222 LEU LEU A . n 
A 1 242 ASP 242 223 223 ASP ASP A . n 
A 1 243 ASN 243 224 224 ASN ASN A . n 
A 1 244 PRO 244 225 225 PRO PRO A . n 
A 1 245 LYS 245 226 226 LYS LYS A . n 
A 1 246 ILE 246 227 227 ILE ILE A . n 
A 1 247 GLN 247 228 228 GLN GLN A . n 
A 1 248 LEU 248 229 229 LEU LEU A . n 
A 1 249 THR 249 230 230 THR THR A . n 
A 1 250 PHE 250 231 231 PHE PHE A . n 
A 1 251 GLU 251 232 232 GLU GLU A . n 
A 1 252 ALA 252 233 233 ALA ALA A . n 
A 1 253 THR 253 234 234 THR THR A . n 
A 1 254 LEU 254 235 235 LEU LEU A . n 
A 1 255 GLN 255 236 236 GLN GLN A . n 
A 1 256 GLN 256 237 237 GLN GLN A . n 
A 1 257 LEU 257 238 238 LEU LEU A . n 
A 1 258 GLU 258 239 239 GLU GLU A . n 
A 1 259 ALA 259 240 240 ALA ALA A . n 
A 1 260 PRO 260 241 241 PRO PRO A . n 
A 1 261 TYR 261 242 242 TYR TYR A . n 
A 1 262 ASN 262 243 243 ASN ASN A . n 
A 1 263 SER 263 244 244 SER SER A . n 
A 1 264 ASP 264 245 245 ASP ASP A . n 
A 1 265 THR 265 246 246 THR THR A . n 
A 1 266 VAL 266 247 247 VAL VAL A . n 
A 1 267 LEU 267 248 248 LEU LEU A . n 
A 1 268 VAL 268 249 249 VAL VAL A . n 
A 1 269 HIS 269 250 250 HIS HIS A . n 
A 1 270 ARG 270 251 251 ARG ARG A . n 
A 1 271 VAL 271 252 252 VAL VAL A . n 
A 1 272 HIS 272 253 253 HIS HIS A . n 
A 1 273 SER 273 254 254 SER SER A . n 
A 1 274 TYR 274 255 255 TYR TYR A . n 
A 1 275 LEU 275 256 256 LEU LEU A . n 
A 1 276 GLU 276 257 257 GLU GLU A . n 
A 1 277 ARG 277 258 258 ARG ARG A . n 
A 1 278 HIS 278 259 259 HIS HIS A . n 
A 1 279 GLY 279 260 260 GLY GLY A . n 
A 1 280 LEU 280 261 261 LEU LEU A . n 
A 1 281 ILE 281 262 262 ILE ILE A . n 
A 1 282 ASN 282 263 263 ASN ASN A . n 
A 1 283 PHE 283 264 264 PHE PHE A . n 
A 1 284 GLY 284 265 265 GLY GLY A . n 
A 1 285 ILE 285 266 266 ILE ILE A . n 
A 1 286 TYR 286 267 267 TYR TYR A . n 
A 1 287 LYS 287 268 268 LYS LYS A . n 
A 1 288 ARG 288 269 269 ARG ARG A . n 
A 1 289 ILE 289 270 270 ILE ILE A . n 
A 1 290 LYS 290 271 271 LYS LYS A . n 
A 1 291 PRO 291 272 272 PRO PRO A . n 
A 1 292 LEU 292 273 273 LEU LEU A . n 
A 1 293 PRO 293 274 274 PRO PRO A . n 
A 1 294 THR 294 275 275 THR THR A . n 
A 1 295 LYS 295 276 276 LYS LYS A . n 
A 1 296 LYS 296 277 277 LYS LYS A . n 
A 1 297 THR 297 278 278 THR THR A . n 
A 1 298 GLY 298 279 279 GLY GLY A . n 
A 1 299 LYS 299 280 280 LYS LYS A . n 
A 1 300 VAL 300 281 281 VAL VAL A . n 
A 1 301 ILE 301 282 282 ILE ILE A . n 
A 1 302 ILE 302 283 283 ILE ILE A . n 
A 1 303 ILE 303 284 284 ILE ILE A . n 
A 1 304 GLY 304 285 285 GLY GLY A . n 
A 1 305 SER 305 286 286 SER SER A . n 
A 1 306 GLY 306 287 287 GLY GLY A . n 
A 1 307 VAL 307 288 288 VAL VAL A . n 
A 1 308 SER 308 289 289 SER SER A . n 
A 1 309 GLY 309 290 290 GLY GLY A . n 
A 1 310 LEU 310 291 291 LEU LEU A . n 
A 1 311 ALA 311 292 292 ALA ALA A . n 
A 1 312 ALA 312 293 293 ALA ALA A . n 
A 1 313 ALA 313 294 294 ALA ALA A . n 
A 1 314 ARG 314 295 295 ARG ARG A . n 
A 1 315 GLN 315 296 296 GLN GLN A . n 
A 1 316 LEU 316 297 297 LEU LEU A . n 
A 1 317 GLN 317 298 298 GLN GLN A . n 
A 1 318 SER 318 299 299 SER SER A . n 
A 1 319 PHE 319 300 300 PHE PHE A . n 
A 1 320 GLY 320 301 301 GLY GLY A . n 
A 1 321 MET 321 302 302 MET MET A . n 
A 1 322 ASP 322 303 303 ASP ASP A . n 
A 1 323 VAL 323 304 304 VAL VAL A . n 
A 1 324 THR 324 305 305 THR THR A . n 
A 1 325 LEU 325 306 306 LEU LEU A . n 
A 1 326 LEU 326 307 307 LEU LEU A . n 
A 1 327 GLU 327 308 308 GLU GLU A . n 
A 1 328 ALA 328 309 309 ALA ALA A . n 
A 1 329 ARG 329 310 310 ARG ARG A . n 
A 1 330 ASP 330 311 311 ASP ASP A . n 
A 1 331 ARG 331 312 312 ARG ARG A . n 
A 1 332 VAL 332 313 313 VAL VAL A . n 
A 1 333 GLY 333 314 314 GLY GLY A . n 
A 1 334 GLY 334 315 315 GLY GLY A . n 
A 1 335 ARG 335 316 316 ARG ARG A . n 
A 1 336 VAL 336 317 317 VAL VAL A . n 
A 1 337 ALA 337 318 318 ALA ALA A . n 
A 1 338 THR 338 319 319 THR THR A . n 
A 1 339 PHE 339 320 320 PHE PHE A . n 
A 1 340 ARG 340 321 321 ARG ARG A . n 
A 1 341 LYS 341 322 322 LYS LYS A . n 
A 1 342 GLY 342 323 323 GLY GLY A . n 
A 1 343 ASN 343 324 324 ASN ASN A . n 
A 1 344 TYR 344 325 325 TYR TYR A . n 
A 1 345 VAL 345 326 326 VAL VAL A . n 
A 1 346 ALA 346 327 327 ALA ALA A . n 
A 1 347 ASP 347 328 328 ASP ASP A . n 
A 1 348 LEU 348 329 329 LEU LEU A . n 
A 1 349 GLY 349 330 330 GLY GLY A . n 
A 1 350 ALA 350 331 331 ALA ALA A . n 
A 1 351 MET 351 332 332 MET MET A . n 
A 1 352 VAL 352 333 333 VAL VAL A . n 
A 1 353 VAL 353 334 334 VAL VAL A . n 
A 1 354 THR 354 335 335 THR THR A . n 
A 1 355 GLY 355 336 336 GLY GLY A . n 
A 1 356 LEU 356 337 337 LEU LEU A . n 
A 1 357 GLY 357 338 338 GLY GLY A . n 
A 1 358 GLY 358 339 339 GLY GLY A . n 
A 1 359 ASN 359 340 340 ASN ASN A . n 
A 1 360 PRO 360 341 341 PRO PRO A . n 
A 1 361 MET 361 342 342 MET MET A . n 
A 1 362 ALA 362 343 343 ALA ALA A . n 
A 1 363 VAL 363 344 344 VAL VAL A . n 
A 1 364 VAL 364 345 345 VAL VAL A . n 
A 1 365 SER 365 346 346 SER SER A . n 
A 1 366 LYS 366 347 347 LYS LYS A . n 
A 1 367 GLN 367 348 348 GLN GLN A . n 
A 1 368 VAL 368 349 349 VAL VAL A . n 
A 1 369 ASN 369 350 350 ASN ASN A . n 
A 1 370 MET 370 351 351 MET MET A . n 
A 1 371 GLU 371 352 352 GLU GLU A . n 
A 1 372 LEU 372 353 353 LEU LEU A . n 
A 1 373 ALA 373 354 354 ALA ALA A . n 
A 1 374 LYS 374 355 355 LYS LYS A . n 
A 1 375 ILE 375 356 356 ILE ILE A . n 
A 1 376 LYS 376 357 357 LYS LYS A . n 
A 1 377 GLN 377 358 358 GLN GLN A . n 
A 1 378 LYS 378 359 359 LYS LYS A . n 
A 1 379 CYS 379 360 360 CYS CYS A . n 
A 1 380 PRO 380 361 361 PRO PRO A . n 
A 1 381 LEU 381 362 362 LEU LEU A . n 
A 1 382 TYR 382 363 363 TYR TYR A . n 
A 1 383 GLU 383 364 364 GLU GLU A . n 
A 1 384 ALA 384 365 365 ALA ALA A . n 
A 1 385 ASN 385 366 366 ASN ASN A . n 
A 1 386 GLY 386 367 367 GLY GLY A . n 
A 1 387 GLN 387 368 368 GLN GLN A . n 
A 1 388 ALA 388 369 369 ALA ALA A . n 
A 1 389 VAL 389 370 370 VAL VAL A . n 
A 1 390 PRO 390 371 371 PRO PRO A . n 
A 1 391 LYS 391 372 372 LYS LYS A . n 
A 1 392 GLU 392 373 373 GLU GLU A . n 
A 1 393 LYS 393 374 374 LYS LYS A . n 
A 1 394 ASP 394 375 375 ASP ASP A . n 
A 1 395 GLU 395 376 376 GLU GLU A . n 
A 1 396 MET 396 377 377 MET MET A . n 
A 1 397 VAL 397 378 378 VAL VAL A . n 
A 1 398 GLU 398 379 379 GLU GLU A . n 
A 1 399 GLN 399 380 380 GLN GLN A . n 
A 1 400 GLU 400 381 381 GLU GLU A . n 
A 1 401 PHE 401 382 382 PHE PHE A . n 
A 1 402 ASN 402 383 383 ASN ASN A . n 
A 1 403 ARG 403 384 384 ARG ARG A . n 
A 1 404 LEU 404 385 385 LEU LEU A . n 
A 1 405 LEU 405 386 386 LEU LEU A . n 
A 1 406 GLU 406 387 387 GLU GLU A . n 
A 1 407 ALA 407 388 388 ALA ALA A . n 
A 1 408 THR 408 389 389 THR THR A . n 
A 1 409 SER 409 390 390 SER SER A . n 
A 1 410 TYR 410 391 391 TYR TYR A . n 
A 1 411 LEU 411 392 392 LEU LEU A . n 
A 1 412 SER 412 393 393 SER SER A . n 
A 1 413 HIS 413 394 394 HIS HIS A . n 
A 1 414 GLN 414 395 395 GLN GLN A . n 
A 1 415 LEU 415 396 396 LEU LEU A . n 
A 1 416 ASP 416 397 397 ASP ASP A . n 
A 1 417 PHE 417 398 398 PHE PHE A . n 
A 1 418 ASN 418 399 399 ASN ASN A . n 
A 1 419 VAL 419 400 400 VAL VAL A . n 
A 1 420 LEU 420 401 401 LEU LEU A . n 
A 1 421 ASN 421 402 402 ASN ASN A . n 
A 1 422 ASN 422 403 403 ASN ASN A . n 
A 1 423 LYS 423 404 404 LYS LYS A . n 
A 1 424 PRO 424 405 405 PRO PRO A . n 
A 1 425 VAL 425 406 406 VAL VAL A . n 
A 1 426 SER 426 407 407 SER SER A . n 
A 1 427 LEU 427 408 408 LEU LEU A . n 
A 1 428 GLY 428 409 409 GLY GLY A . n 
A 1 429 GLN 429 410 410 GLN GLN A . n 
A 1 430 ALA 430 411 411 ALA ALA A . n 
A 1 431 LEU 431 412 412 LEU LEU A . n 
A 1 432 GLU 432 413 413 GLU GLU A . n 
A 1 433 VAL 433 414 414 VAL VAL A . n 
A 1 434 VAL 434 415 415 VAL VAL A . n 
A 1 435 ILE 435 416 416 ILE ILE A . n 
A 1 436 GLN 436 417 417 GLN GLN A . n 
A 1 437 LEU 437 418 418 LEU LEU A . n 
A 1 438 GLN 438 419 419 GLN GLN A . n 
A 1 439 GLU 439 420 420 GLU GLU A . n 
A 1 440 LYS 440 421 421 LYS LYS A . n 
A 1 441 HIS 441 422 422 HIS HIS A . n 
A 1 442 VAL 442 423 423 VAL VAL A . n 
A 1 443 LYS 443 424 424 LYS LYS A . n 
A 1 444 ASP 444 425 425 ASP ASP A . n 
A 1 445 GLU 445 426 426 GLU GLU A . n 
A 1 446 GLN 446 427 427 GLN GLN A . n 
A 1 447 ILE 447 428 428 ILE ILE A . n 
A 1 448 GLU 448 429 429 GLU GLU A . n 
A 1 449 HIS 449 430 430 HIS HIS A . n 
A 1 450 TRP 450 431 431 TRP TRP A . n 
A 1 451 LYS 451 432 432 LYS LYS A . n 
A 1 452 LYS 452 433 433 LYS LYS A . n 
A 1 453 ILE 453 434 434 ILE ILE A . n 
A 1 454 VAL 454 435 435 VAL VAL A . n 
A 1 455 LYS 455 436 436 LYS LYS A . n 
A 1 456 THR 456 437 437 THR THR A . n 
A 1 457 GLN 457 438 438 GLN GLN A . n 
A 1 458 GLU 458 439 439 GLU GLU A . n 
A 1 459 GLU 459 440 440 GLU GLU A . n 
A 1 460 LEU 460 441 441 LEU LEU A . n 
A 1 461 LYS 461 442 442 LYS LYS A . n 
A 1 462 GLU 462 443 443 GLU GLU A . n 
A 1 463 LEU 463 444 444 LEU LEU A . n 
A 1 464 LEU 464 445 445 LEU LEU A . n 
A 1 465 ASN 465 446 446 ASN ASN A . n 
A 1 466 LYS 466 447 447 LYS LYS A . n 
A 1 467 MET 467 448 448 MET MET A . n 
A 1 468 VAL 468 449 449 VAL VAL A . n 
A 1 469 ASN 469 450 450 ASN ASN A . n 
A 1 470 LEU 470 451 451 LEU LEU A . n 
A 1 471 LYS 471 452 452 LYS LYS A . n 
A 1 472 GLU 472 453 453 GLU GLU A . n 
A 1 473 LYS 473 454 454 LYS LYS A . n 
A 1 474 ILE 474 455 455 ILE ILE A . n 
A 1 475 LYS 475 456 456 LYS LYS A . n 
A 1 476 GLU 476 457 457 GLU GLU A . n 
A 1 477 LEU 477 458 458 LEU LEU A . n 
A 1 478 HIS 478 459 459 HIS HIS A . n 
A 1 479 GLN 479 460 460 GLN GLN A . n 
A 1 480 GLN 480 461 461 GLN GLN A . n 
A 1 481 TYR 481 462 462 TYR TYR A . n 
A 1 482 LYS 482 463 463 LYS LYS A . n 
A 1 483 GLU 483 464 464 GLU GLU A . n 
A 1 484 ALA 484 465 465 ALA ALA A . n 
A 1 485 SER 485 466 466 SER SER A . n 
A 1 486 GLU 486 467 467 GLU GLU A . n 
A 1 487 VAL 487 468 468 VAL VAL A . n 
A 1 488 LYS 488 469 469 LYS LYS A . n 
A 1 489 PRO 489 470 470 PRO PRO A . n 
A 1 490 PRO 490 471 471 PRO PRO A . n 
A 1 491 ARG 491 472 472 ARG ARG A . n 
A 1 492 ASP 492 473 473 ASP ASP A . n 
A 1 493 ILE 493 474 474 ILE ILE A . n 
A 1 494 THR 494 475 475 THR THR A . n 
A 1 495 ALA 495 476 476 ALA ALA A . n 
A 1 496 GLU 496 477 477 GLU GLU A . n 
A 1 497 PHE 497 478 478 PHE PHE A . n 
A 1 498 LEU 498 479 479 LEU LEU A . n 
A 1 499 VAL 499 480 480 VAL VAL A . n 
A 1 500 LYS 500 481 481 LYS LYS A . n 
A 1 501 SER 501 482 482 SER SER A . n 
A 1 502 LYS 502 483 483 LYS LYS A . n 
A 1 503 HIS 503 484 484 HIS HIS A . n 
A 1 504 ARG 504 485 485 ARG ARG A . n 
A 1 505 ASP 505 486 486 ASP ASP A . n 
A 1 506 LEU 506 487 487 LEU LEU A . n 
A 1 507 THR 507 488 488 THR THR A . n 
A 1 508 ALA 508 489 489 ALA ALA A . n 
A 1 509 LEU 509 490 490 LEU LEU A . n 
A 1 510 CYS 510 491 491 CYS CYS A . n 
A 1 511 LYS 511 492 492 LYS LYS A . n 
A 1 512 GLU 512 493 493 GLU GLU A . n 
A 1 513 TYR 513 494 494 TYR TYR A . n 
A 1 514 ASP 514 495 495 ASP ASP A . n 
A 1 515 GLU 515 496 496 GLU GLU A . n 
A 1 516 LEU 516 497 497 LEU LEU A . n 
A 1 517 ALA 517 498 498 ALA ALA A . n 
A 1 518 GLU 518 499 499 GLU GLU A . n 
A 1 519 THR 519 500 500 THR THR A . n 
A 1 520 GLN 520 501 501 GLN GLN A . n 
A 1 521 GLY 521 502 502 GLY GLY A . n 
A 1 522 LYS 522 503 503 LYS LYS A . n 
A 1 523 LEU 523 504 504 LEU LEU A . n 
A 1 524 GLU 524 505 505 GLU GLU A . n 
A 1 525 GLU 525 506 506 GLU GLU A . n 
A 1 526 LYS 526 507 507 LYS LYS A . n 
A 1 527 LEU 527 508 508 LEU LEU A . n 
A 1 528 GLN 528 509 509 GLN GLN A . n 
A 1 529 GLU 529 510 510 GLU GLU A . n 
A 1 530 LEU 530 511 511 LEU LEU A . n 
A 1 531 GLU 531 512 512 GLU GLU A . n 
A 1 532 ALA 532 513 513 ALA ALA A . n 
A 1 533 ASN 533 514 514 ASN ASN A . n 
A 1 534 PRO 534 515 515 PRO PRO A . n 
A 1 535 PRO 535 516 516 PRO PRO A . n 
A 1 536 SER 536 517 517 SER SER A . n 
A 1 537 ASP 537 518 518 ASP ASP A . n 
A 1 538 VAL 538 519 519 VAL VAL A . n 
A 1 539 TYR 539 520 520 TYR TYR A . n 
A 1 540 LEU 540 521 521 LEU LEU A . n 
A 1 541 SER 541 522 522 SER SER A . n 
A 1 542 SER 542 523 523 SER SER A . n 
A 1 543 ARG 543 524 524 ARG ARG A . n 
A 1 544 ASP 544 525 525 ASP ASP A . n 
A 1 545 ARG 545 526 526 ARG ARG A . n 
A 1 546 GLN 546 527 527 GLN GLN A . n 
A 1 547 ILE 547 528 528 ILE ILE A . n 
A 1 548 LEU 548 529 529 LEU LEU A . n 
A 1 549 ASP 549 530 530 ASP ASP A . n 
A 1 550 TRP 550 531 531 TRP TRP A . n 
A 1 551 HIS 551 532 532 HIS HIS A . n 
A 1 552 PHE 552 533 533 PHE PHE A . n 
A 1 553 ALA 553 534 534 ALA ALA A . n 
A 1 554 ASN 554 535 535 ASN ASN A . n 
A 1 555 LEU 555 536 536 LEU LEU A . n 
A 1 556 GLU 556 537 537 GLU GLU A . n 
A 1 557 PHE 557 538 538 PHE PHE A . n 
A 1 558 ALA 558 539 539 ALA ALA A . n 
A 1 559 ASN 559 540 540 ASN ASN A . n 
A 1 560 ALA 560 541 541 ALA ALA A . n 
A 1 561 THR 561 542 542 THR THR A . n 
A 1 562 PRO 562 543 543 PRO PRO A . n 
A 1 563 LEU 563 544 544 LEU LEU A . n 
A 1 564 SER 564 545 545 SER SER A . n 
A 1 565 THR 565 546 546 THR THR A . n 
A 1 566 LEU 566 547 547 LEU LEU A . n 
A 1 567 SER 567 548 548 SER SER A . n 
A 1 568 LEU 568 549 549 LEU LEU A . n 
A 1 569 LYS 569 550 550 LYS LYS A . n 
A 1 570 HIS 570 551 551 HIS HIS A . n 
A 1 571 TRP 571 552 552 TRP TRP A . n 
A 1 572 ASP 572 553 553 ASP ASP A . n 
A 1 573 GLN 573 554 554 GLN GLN A . n 
A 1 574 ASP 574 555 555 ASP ASP A . n 
A 1 575 ASP 575 556 556 ASP ASP A . n 
A 1 576 ASP 576 557 557 ASP ASP A . n 
A 1 577 PHE 577 558 558 PHE PHE A . n 
A 1 578 GLU 578 559 559 GLU GLU A . n 
A 1 579 PHE 579 560 560 PHE PHE A . n 
A 1 580 THR 580 561 561 THR THR A . n 
A 1 581 GLY 581 562 562 GLY GLY A . n 
A 1 582 SER 582 563 563 SER SER A . n 
A 1 583 HIS 583 564 564 HIS HIS A . n 
A 1 584 LEU 584 565 565 LEU LEU A . n 
A 1 585 THR 585 566 566 THR THR A . n 
A 1 586 VAL 586 567 567 VAL VAL A . n 
A 1 587 ARG 587 568 568 ARG ARG A . n 
A 1 588 ASN 588 569 569 ASN ASN A . n 
A 1 589 GLY 589 570 570 GLY GLY A . n 
A 1 590 TYR 590 571 571 TYR TYR A . n 
A 1 591 SER 591 572 572 SER SER A . n 
A 1 592 CYS 592 573 573 CYS CYS A . n 
A 1 593 VAL 593 574 574 VAL VAL A . n 
A 1 594 PRO 594 575 575 PRO PRO A . n 
A 1 595 VAL 595 576 576 VAL VAL A . n 
A 1 596 ALA 596 577 577 ALA ALA A . n 
A 1 597 LEU 597 578 578 LEU LEU A . n 
A 1 598 ALA 598 579 579 ALA ALA A . n 
A 1 599 GLU 599 580 580 GLU GLU A . n 
A 1 600 GLY 600 581 581 GLY GLY A . n 
A 1 601 LEU 601 582 582 LEU LEU A . n 
A 1 602 ASP 602 583 583 ASP ASP A . n 
A 1 603 ILE 603 584 584 ILE ILE A . n 
A 1 604 LYS 604 585 585 LYS LYS A . n 
A 1 605 LEU 605 586 586 LEU LEU A . n 
A 1 606 ASN 606 587 587 ASN ASN A . n 
A 1 607 THR 607 588 588 THR THR A . n 
A 1 608 ALA 608 589 589 ALA ALA A . n 
A 1 609 VAL 609 590 590 VAL VAL A . n 
A 1 610 ARG 610 591 591 ARG ARG A . n 
A 1 611 GLN 611 592 592 GLN GLN A . n 
A 1 612 VAL 612 593 593 VAL VAL A . n 
A 1 613 ARG 613 594 594 ARG ARG A . n 
A 1 614 TYR 614 595 595 TYR TYR A . n 
A 1 615 THR 615 596 596 THR THR A . n 
A 1 616 ALA 616 597 597 ALA ALA A . n 
A 1 617 SER 617 598 598 SER SER A . n 
A 1 618 GLY 618 599 599 GLY GLY A . n 
A 1 619 CYS 619 600 600 CYS CYS A . n 
A 1 620 GLU 620 601 601 GLU GLU A . n 
A 1 621 VAL 621 602 602 VAL VAL A . n 
A 1 622 ILE 622 603 603 ILE ILE A . n 
A 1 623 ALA 623 604 604 ALA ALA A . n 
A 1 624 VAL 624 605 605 VAL VAL A . n 
A 1 625 ASN 625 606 606 ASN ASN A . n 
A 1 626 THR 626 607 607 THR THR A . n 
A 1 627 ARG 627 608 608 ARG ARG A . n 
A 1 628 SER 628 609 609 SER SER A . n 
A 1 629 THR 629 610 610 THR THR A . n 
A 1 630 SER 630 611 611 SER SER A . n 
A 1 631 GLN 631 612 612 GLN GLN A . n 
A 1 632 THR 632 613 613 THR THR A . n 
A 1 633 PHE 633 614 614 PHE PHE A . n 
A 1 634 ILE 634 615 615 ILE ILE A . n 
A 1 635 TYR 635 616 616 TYR TYR A . n 
A 1 636 LYS 636 617 617 LYS LYS A . n 
A 1 637 CYS 637 618 618 CYS CYS A . n 
A 1 638 ASP 638 619 619 ASP ASP A . n 
A 1 639 ALA 639 620 620 ALA ALA A . n 
A 1 640 VAL 640 621 621 VAL VAL A . n 
A 1 641 LEU 641 622 622 LEU LEU A . n 
A 1 642 CYS 642 623 623 CYS CYS A . n 
A 1 643 THR 643 624 624 THR THR A . n 
A 1 644 LEU 644 625 625 LEU LEU A . n 
A 1 645 PRO 645 626 626 PRO PRO A . n 
A 1 646 LEU 646 627 627 LEU LEU A . n 
A 1 647 GLY 647 628 628 GLY GLY A . n 
A 1 648 VAL 648 629 629 VAL VAL A . n 
A 1 649 LEU 649 630 630 LEU LEU A . n 
A 1 650 LYS 650 631 631 LYS LYS A . n 
A 1 651 GLN 651 632 632 GLN GLN A . n 
A 1 652 GLN 652 633 633 GLN GLN A . n 
A 1 653 PRO 653 634 634 PRO PRO A . n 
A 1 654 PRO 654 635 635 PRO PRO A . n 
A 1 655 ALA 655 636 636 ALA ALA A . n 
A 1 656 VAL 656 637 637 VAL VAL A . n 
A 1 657 GLN 657 638 638 GLN GLN A . n 
A 1 658 PHE 658 639 639 PHE PHE A . n 
A 1 659 VAL 659 640 640 VAL VAL A . n 
A 1 660 PRO 660 641 641 PRO PRO A . n 
A 1 661 PRO 661 642 642 PRO PRO A . n 
A 1 662 LEU 662 643 643 LEU LEU A . n 
A 1 663 PRO 663 644 644 PRO PRO A . n 
A 1 664 GLU 664 645 645 GLU GLU A . n 
A 1 665 TRP 665 646 646 TRP TRP A . n 
A 1 666 LYS 666 647 647 LYS LYS A . n 
A 1 667 THR 667 648 648 THR THR A . n 
A 1 668 SER 668 649 649 SER SER A . n 
A 1 669 ALA 669 650 650 ALA ALA A . n 
A 1 670 VAL 670 651 651 VAL VAL A . n 
A 1 671 GLN 671 652 652 GLN GLN A . n 
A 1 672 ARG 672 653 653 ARG ARG A . n 
A 1 673 MET 673 654 654 MET MET A . n 
A 1 674 GLY 674 655 655 GLY GLY A . n 
A 1 675 PHE 675 656 656 PHE PHE A . n 
A 1 676 GLY 676 657 657 GLY GLY A . n 
A 1 677 ASN 677 658 658 ASN ASN A . n 
A 1 678 LEU 678 659 659 LEU LEU A . n 
A 1 679 ASN 679 660 660 ASN ASN A . n 
A 1 680 LYS 680 661 661 LYS LYS A . n 
A 1 681 VAL 681 662 662 VAL VAL A . n 
A 1 682 VAL 682 663 663 VAL VAL A . n 
A 1 683 LEU 683 664 664 LEU LEU A . n 
A 1 684 CYS 684 665 665 CYS CYS A . n 
A 1 685 PHE 685 666 666 PHE PHE A . n 
A 1 686 ASP 686 667 667 ASP ASP A . n 
A 1 687 ARG 687 668 668 ARG ARG A . n 
A 1 688 VAL 688 669 669 VAL VAL A . n 
A 1 689 PHE 689 670 670 PHE PHE A . n 
A 1 690 TRP 690 671 671 TRP TRP A . n 
A 1 691 ASP 691 672 672 ASP ASP A . n 
A 1 692 PRO 692 673 673 PRO PRO A . n 
A 1 693 SER 693 674 674 SER SER A . n 
A 1 694 VAL 694 675 675 VAL VAL A . n 
A 1 695 ASN 695 676 676 ASN ASN A . n 
A 1 696 LEU 696 677 677 LEU LEU A . n 
A 1 697 PHE 697 678 678 PHE PHE A . n 
A 1 698 GLY 698 679 679 GLY GLY A . n 
A 1 699 HIS 699 680 680 HIS HIS A . n 
A 1 700 VAL 700 681 681 VAL VAL A . n 
A 1 701 GLY 701 682 682 GLY GLY A . n 
A 1 702 SER 702 683 683 SER SER A . n 
A 1 703 THR 703 684 684 THR THR A . n 
A 1 704 THR 704 685 685 THR THR A . n 
A 1 705 ALA 705 686 686 ALA ALA A . n 
A 1 706 SER 706 687 687 SER SER A . n 
A 1 707 ARG 707 688 688 ARG ARG A . n 
A 1 708 GLY 708 689 689 GLY GLY A . n 
A 1 709 GLU 709 690 690 GLU GLU A . n 
A 1 710 LEU 710 691 691 LEU LEU A . n 
A 1 711 PHE 711 692 692 PHE PHE A . n 
A 1 712 LEU 712 693 693 LEU LEU A . n 
A 1 713 PHE 713 694 694 PHE PHE A . n 
A 1 714 TRP 714 695 695 TRP TRP A . n 
A 1 715 ASN 715 696 696 ASN ASN A . n 
A 1 716 LEU 716 697 697 LEU LEU A . n 
A 1 717 TYR 717 698 698 TYR TYR A . n 
A 1 718 LYS 718 699 699 LYS LYS A . n 
A 1 719 ALA 719 700 700 ALA ALA A . n 
A 1 720 PRO 720 701 701 PRO PRO A . n 
A 1 721 ILE 721 702 702 ILE ILE A . n 
A 1 722 LEU 722 703 703 LEU LEU A . n 
A 1 723 LEU 723 704 704 LEU LEU A . n 
A 1 724 ALA 724 705 705 ALA ALA A . n 
A 1 725 LEU 725 706 706 LEU LEU A . n 
A 1 726 VAL 726 707 707 VAL VAL A . n 
A 1 727 ALA 727 708 708 ALA ALA A . n 
A 1 728 GLY 728 709 709 GLY GLY A . n 
A 1 729 GLU 729 710 710 GLU GLU A . n 
A 1 730 ALA 730 711 711 ALA ALA A . n 
A 1 731 ALA 731 712 712 ALA ALA A . n 
A 1 732 GLY 732 713 713 GLY GLY A . n 
A 1 733 ILE 733 714 714 ILE ILE A . n 
A 1 734 MET 734 715 715 MET MET A . n 
A 1 735 GLU 735 716 716 GLU GLU A . n 
A 1 736 ASN 736 717 717 ASN ASN A . n 
A 1 737 ILE 737 718 718 ILE ILE A . n 
A 1 738 SER 738 719 719 SER SER A . n 
A 1 739 ASP 739 720 720 ASP ASP A . n 
A 1 740 ASP 740 721 721 ASP ASP A . n 
A 1 741 VAL 741 722 722 VAL VAL A . n 
A 1 742 ILE 742 723 723 ILE ILE A . n 
A 1 743 VAL 743 724 724 VAL VAL A . n 
A 1 744 GLY 744 725 725 GLY GLY A . n 
A 1 745 ARG 745 726 726 ARG ARG A . n 
A 1 746 CYS 746 727 727 CYS CYS A . n 
A 1 747 LEU 747 728 728 LEU LEU A . n 
A 1 748 ALA 748 729 729 ALA ALA A . n 
A 1 749 ILE 749 730 730 ILE ILE A . n 
A 1 750 LEU 750 731 731 LEU LEU A . n 
A 1 751 LYS 751 732 732 LYS LYS A . n 
A 1 752 GLY 752 733 733 GLY GLY A . n 
A 1 753 ILE 753 734 734 ILE ILE A . n 
A 1 754 PHE 754 735 735 PHE PHE A . n 
A 1 755 GLY 755 736 736 GLY GLY A . n 
A 1 756 SER 756 737 737 SER SER A . n 
A 1 757 SER 757 738 738 SER SER A . n 
A 1 758 ALA 758 739 739 ALA ALA A . n 
A 1 759 VAL 759 740 740 VAL VAL A . n 
A 1 760 PRO 760 741 741 PRO PRO A . n 
A 1 761 GLN 761 742 742 GLN GLN A . n 
A 1 762 PRO 762 743 743 PRO PRO A . n 
A 1 763 LYS 763 744 744 LYS LYS A . n 
A 1 764 GLU 764 745 745 GLU GLU A . n 
A 1 765 THR 765 746 746 THR THR A . n 
A 1 766 VAL 766 747 747 VAL VAL A . n 
A 1 767 VAL 767 748 748 VAL VAL A . n 
A 1 768 SER 768 749 749 SER SER A . n 
A 1 769 ARG 769 750 750 ARG ARG A . n 
A 1 770 TRP 770 751 751 TRP TRP A . n 
A 1 771 ARG 771 752 752 ARG ARG A . n 
A 1 772 ALA 772 753 753 ALA ALA A . n 
A 1 773 ASP 773 754 754 ASP ASP A . n 
A 1 774 PRO 774 755 755 PRO PRO A . n 
A 1 775 TRP 775 756 756 TRP TRP A . n 
A 1 776 ALA 776 757 757 ALA ALA A . n 
A 1 777 ARG 777 758 758 ARG ARG A . n 
A 1 778 GLY 778 759 759 GLY GLY A . n 
A 1 779 SER 779 760 760 SER SER A . n 
A 1 780 TYR 780 761 761 TYR TYR A . n 
A 1 781 SER 781 762 762 SER SER A . n 
A 1 782 TYR 782 763 763 TYR TYR A . n 
A 1 783 VAL 783 764 764 VAL VAL A . n 
A 1 784 ALA 784 765 765 ALA ALA A . n 
A 1 785 ALA 785 766 766 ALA ALA A . n 
A 1 786 GLY 786 767 767 GLY GLY A . n 
A 1 787 SER 787 768 768 SER SER A . n 
A 1 788 SER 788 769 769 SER SER A . n 
A 1 789 GLY 789 770 770 GLY GLY A . n 
A 1 790 ASN 790 771 771 ASN ASN A . n 
A 1 791 ASP 791 772 772 ASP ASP A . n 
A 1 792 TYR 792 773 773 TYR TYR A . n 
A 1 793 ASP 793 774 774 ASP ASP A . n 
A 1 794 LEU 794 775 775 LEU LEU A . n 
A 1 795 MET 795 776 776 MET MET A . n 
A 1 796 ALA 796 777 777 ALA ALA A . n 
A 1 797 GLN 797 778 778 GLN GLN A . n 
A 1 798 PRO 798 779 779 PRO PRO A . n 
A 1 799 ILE 799 780 780 ILE ILE A . n 
A 1 800 THR 800 781 781 THR THR A . n 
A 1 801 PRO 801 782 782 PRO PRO A . n 
A 1 802 GLY 802 783 783 GLY GLY A . n 
A 1 803 PRO 803 784 784 PRO PRO A . n 
A 1 804 SER 804 785 785 SER SER A . n 
A 1 805 ILE 805 786 786 ILE ILE A . n 
A 1 806 PRO 806 787 787 PRO PRO A . n 
A 1 807 GLY 807 788 788 GLY GLY A . n 
A 1 808 ALA 808 789 789 ALA ALA A . n 
A 1 809 PRO 809 790 790 PRO PRO A . n 
A 1 810 GLN 810 791 791 GLN GLN A . n 
A 1 811 PRO 811 792 792 PRO PRO A . n 
A 1 812 ILE 812 793 793 ILE ILE A . n 
A 1 813 PRO 813 794 794 PRO PRO A . n 
A 1 814 ARG 814 795 795 ARG ARG A . n 
A 1 815 LEU 815 796 796 LEU LEU A . n 
A 1 816 PHE 816 797 797 PHE PHE A . n 
A 1 817 PHE 817 798 798 PHE PHE A . n 
A 1 818 ALA 818 799 799 ALA ALA A . n 
A 1 819 GLY 819 800 800 GLY GLY A . n 
A 1 820 GLU 820 801 801 GLU GLU A . n 
A 1 821 HIS 821 802 802 HIS HIS A . n 
A 1 822 THR 822 803 803 THR THR A . n 
A 1 823 ILE 823 804 804 ILE ILE A . n 
A 1 824 ARG 824 805 805 ARG ARG A . n 
A 1 825 ASN 825 806 806 ASN ASN A . n 
A 1 826 TYR 826 807 807 TYR TYR A . n 
A 1 827 PRO 827 808 808 PRO PRO A . n 
A 1 828 ALA 828 809 809 ALA ALA A . n 
A 1 829 THR 829 810 810 THR THR A . n 
A 1 830 VAL 830 811 811 VAL VAL A . n 
A 1 831 HIS 831 812 812 HIS HIS A . n 
A 1 832 GLY 832 813 813 GLY GLY A . n 
A 1 833 ALA 833 814 814 ALA ALA A . n 
A 1 834 LEU 834 815 815 LEU LEU A . n 
A 1 835 LEU 835 816 816 LEU LEU A . n 
A 1 836 SER 836 817 817 SER SER A . n 
A 1 837 GLY 837 818 818 GLY GLY A . n 
A 1 838 LEU 838 819 819 LEU LEU A . n 
A 1 839 ARG 839 820 820 ARG ARG A . n 
A 1 840 GLU 840 821 821 GLU GLU A . n 
A 1 841 ALA 841 822 822 ALA ALA A . n 
A 1 842 GLY 842 823 823 GLY GLY A . n 
A 1 843 ARG 843 824 824 ARG ARG A . n 
A 1 844 ILE 844 825 825 ILE ILE A . n 
A 1 845 ALA 845 826 826 ALA ALA A . n 
A 1 846 ASP 846 827 827 ASP ASP A . n 
A 1 847 GLN 847 828 828 GLN GLN A . n 
A 1 848 PHE 848 829 829 PHE PHE A . n 
A 1 849 LEU 849 830 830 LEU LEU A . n 
A 1 850 GLY 850 831 831 GLY GLY A . n 
A 1 851 ALA 851 832 832 ALA ALA A . n 
A 1 852 MET 852 833 833 MET MET A . n 
A 1 853 TYR 853 834 834 TYR TYR A . n 
A 1 854 THR 854 835 835 THR THR A . n 
A 1 855 LEU 855 836 836 LEU LEU A . n 
A 1 856 PRO 856 837 ?   ?   ?   A . n 
A 1 857 ARG 857 838 ?   ?   ?   A . n 
A 1 858 GLN 858 839 ?   ?   ?   A . n 
A 1 859 ALA 859 840 ?   ?   ?   A . n 
A 1 860 THR 860 841 ?   ?   ?   A . n 
A 1 861 PRO 861 842 ?   ?   ?   A . n 
A 1 862 GLY 862 843 ?   ?   ?   A . n 
A 1 863 VAL 863 844 ?   ?   ?   A . n 
A 1 864 PRO 864 845 ?   ?   ?   A . n 
A 1 865 ALA 865 846 ?   ?   ?   A . n 
A 1 866 GLN 866 847 ?   ?   ?   A . n 
A 1 867 GLN 867 848 ?   ?   ?   A . n 
A 1 868 SER 868 849 ?   ?   ?   A . n 
A 1 869 PRO 869 850 ?   ?   ?   A . n 
A 1 870 SER 870 851 ?   ?   ?   A . n 
A 1 871 MET 871 852 ?   ?   ?   A . n 
B 2 1   GLY 1   297 ?   ?   ?   B . n 
B 2 2   PRO 2   298 ?   ?   ?   B . n 
B 2 3   LEU 3   299 ?   ?   ?   B . n 
B 2 4   GLY 4   300 ?   ?   ?   B . n 
B 2 5   SER 5   301 ?   ?   ?   B . n 
B 2 6   PRO 6   302 ?   ?   ?   B . n 
B 2 7   GLU 7   303 ?   ?   ?   B . n 
B 2 8   PHE 8   304 ?   ?   ?   B . n 
B 2 9   ARG 9   305 ?   ?   ?   B . n 
B 2 10  ALA 10  306 ?   ?   ?   B . n 
B 2 11  LYS 11  307 ?   ?   ?   B . n 
B 2 12  ARG 12  308 308 ARG ARG B . n 
B 2 13  LYS 13  309 309 LYS LYS B . n 
B 2 14  PRO 14  310 310 PRO PRO B . n 
B 2 15  PRO 15  311 311 PRO PRO B . n 
B 2 16  LYS 16  312 312 LYS LYS B . n 
B 2 17  GLY 17  313 313 GLY GLY B . n 
B 2 18  MET 18  314 314 MET MET B . n 
B 2 19  PHE 19  315 315 PHE PHE B . n 
B 2 20  LEU 20  316 316 LEU LEU B . n 
B 2 21  SER 21  317 317 SER SER B . n 
B 2 22  GLN 22  318 318 GLN GLN B . n 
B 2 23  GLU 23  319 319 GLU GLU B . n 
B 2 24  ASP 24  320 320 ASP ASP B . n 
B 2 25  VAL 25  321 321 VAL VAL B . n 
B 2 26  GLU 26  322 322 GLU GLU B . n 
B 2 27  ALA 27  323 323 ALA ALA B . n 
B 2 28  VAL 28  324 324 VAL VAL B . n 
B 2 29  SER 29  325 325 SER SER B . n 
B 2 30  ALA 30  326 326 ALA ALA B . n 
B 2 31  ASN 31  327 327 ASN ASN B . n 
B 2 32  ALA 32  328 328 ALA ALA B . n 
B 2 33  THR 33  329 329 THR THR B . n 
B 2 34  ALA 34  330 330 ALA ALA B . n 
B 2 35  ALA 35  331 331 ALA ALA B . n 
B 2 36  THR 36  332 332 THR THR B . n 
B 2 37  THR 37  333 333 THR THR B . n 
B 2 38  VAL 38  334 334 VAL VAL B . n 
B 2 39  LEU 39  335 335 LEU LEU B . n 
B 2 40  ARG 40  336 336 ARG ARG B . n 
B 2 41  GLN 41  337 337 GLN GLN B . n 
B 2 42  LEU 42  338 338 LEU LEU B . n 
B 2 43  ASP 43  339 339 ASP ASP B . n 
B 2 44  MET 44  340 340 MET MET B . n 
B 2 45  GLU 45  341 341 GLU GLU B . n 
B 2 46  LEU 46  342 342 LEU LEU B . n 
B 2 47  VAL 47  343 343 VAL VAL B . n 
B 2 48  SER 48  344 344 SER SER B . n 
B 2 49  VAL 49  345 345 VAL VAL B . n 
B 2 50  LYS 50  346 346 LYS LYS B . n 
B 2 51  ARG 51  347 347 ARG ARG B . n 
B 2 52  GLN 52  348 348 GLN GLN B . n 
B 2 53  ILE 53  349 349 ILE ILE B . n 
B 2 54  GLN 54  350 350 GLN GLN B . n 
B 2 55  ASN 55  351 351 ASN ASN B . n 
B 2 56  ILE 56  352 352 ILE ILE B . n 
B 2 57  LYS 57  353 353 LYS LYS B . n 
B 2 58  GLN 58  354 354 GLN GLN B . n 
B 2 59  THR 59  355 355 THR THR B . n 
B 2 60  ASN 60  356 356 ASN ASN B . n 
B 2 61  SER 61  357 357 SER SER B . n 
B 2 62  ALA 62  358 358 ALA ALA B . n 
B 2 63  LEU 63  359 359 LEU LEU B . n 
B 2 64  LYS 64  360 360 LYS LYS B . n 
B 2 65  GLU 65  361 361 GLU GLU B . n 
B 2 66  LYS 66  362 362 LYS LYS B . n 
B 2 67  LEU 67  363 363 LEU LEU B . n 
B 2 68  ASP 68  364 364 ASP ASP B . n 
B 2 69  GLY 69  365 365 GLY GLY B . n 
B 2 70  GLY 70  366 366 GLY GLY B . n 
B 2 71  ILE 71  367 367 ILE ILE B . n 
B 2 72  GLU 72  368 368 GLU GLU B . n 
B 2 73  PRO 73  369 369 PRO PRO B . n 
B 2 74  TYR 74  370 370 TYR TYR B . n 
B 2 75  ARG 75  371 371 ARG ARG B . n 
B 2 76  LEU 76  372 372 LEU LEU B . n 
B 2 77  PRO 77  373 373 PRO PRO B . n 
B 2 78  GLU 78  374 374 GLU GLU B . n 
B 2 79  VAL 79  375 375 VAL VAL B . n 
B 2 80  ILE 80  376 376 ILE ILE B . n 
B 2 81  GLN 81  377 377 GLN GLN B . n 
B 2 82  LYS 82  378 378 LYS LYS B . n 
B 2 83  CYS 83  379 379 CYS CYS B . n 
B 2 84  ASN 84  380 380 ASN ASN B . n 
B 2 85  ALA 85  381 381 ALA ALA B . n 
B 2 86  ARG 86  382 382 ARG ARG B . n 
B 2 87  TRP 87  383 383 TRP TRP B . n 
B 2 88  THR 88  384 384 THR THR B . n 
B 2 89  THR 89  385 385 THR THR B . n 
B 2 90  GLU 90  386 386 GLU GLU B . n 
B 2 91  GLU 91  387 387 GLU GLU B . n 
B 2 92  GLN 92  388 388 GLN GLN B . n 
B 2 93  LEU 93  389 389 LEU LEU B . n 
B 2 94  LEU 94  390 390 LEU LEU B . n 
B 2 95  ALA 95  391 391 ALA ALA B . n 
B 2 96  VAL 96  392 392 VAL VAL B . n 
B 2 97  GLN 97  393 393 GLN GLN B . n 
B 2 98  ALA 98  394 394 ALA ALA B . n 
B 2 99  ILE 99  395 395 ILE ILE B . n 
B 2 100 ARG 100 396 396 ARG ARG B . n 
B 2 101 LYS 101 397 397 LYS LYS B . n 
B 2 102 TYR 102 398 398 TYR TYR B . n 
B 2 103 GLY 103 399 399 GLY GLY B . n 
B 2 104 ARG 104 400 400 ARG ARG B . n 
B 2 105 ASP 105 401 401 ASP ASP B . n 
B 2 106 PHE 106 402 402 PHE PHE B . n 
B 2 107 GLN 107 403 403 GLN GLN B . n 
B 2 108 ALA 108 404 404 ALA ALA B . n 
B 2 109 ILE 109 405 405 ILE ILE B . n 
B 2 110 SER 110 406 406 SER SER B . n 
B 2 111 ASP 111 407 407 ASP ASP B . n 
B 2 112 VAL 112 408 408 VAL VAL B . n 
B 2 113 ILE 113 409 409 ILE ILE B . n 
B 2 114 GLY 114 410 410 GLY GLY B . n 
B 2 115 ASN 115 411 411 ASN ASN B . n 
B 2 116 LYS 116 412 412 LYS LYS B . n 
B 2 117 SER 117 413 413 SER SER B . n 
B 2 118 VAL 118 414 414 VAL VAL B . n 
B 2 119 VAL 119 415 415 VAL VAL B . n 
B 2 120 GLN 120 416 416 GLN GLN B . n 
B 2 121 VAL 121 417 417 VAL VAL B . n 
B 2 122 LYS 122 418 418 LYS LYS B . n 
B 2 123 ASN 123 419 419 ASN ASN B . n 
B 2 124 PHE 124 420 420 PHE PHE B . n 
B 2 125 PHE 125 421 421 PHE PHE B . n 
B 2 126 VAL 126 422 422 VAL VAL B . n 
B 2 127 ASN 127 423 423 ASN ASN B . n 
B 2 128 TYR 128 424 424 TYR TYR B . n 
B 2 129 ARG 129 425 425 ARG ARG B . n 
B 2 130 ARG 130 426 426 ARG ARG B . n 
B 2 131 ARG 131 427 427 ARG ARG B . n 
B 2 132 PHE 132 428 428 PHE PHE B . n 
B 2 133 ASN 133 429 429 ASN ASN B . n 
B 2 134 ILE 134 430 430 ILE ILE B . n 
B 2 135 ASP 135 431 431 ASP ASP B . n 
B 2 136 GLU 136 432 432 GLU GLU B . n 
B 2 137 VAL 137 433 433 VAL VAL B . n 
B 2 138 LEU 138 434 434 LEU LEU B . n 
B 2 139 GLN 139 435 435 GLN GLN B . n 
B 2 140 GLU 140 436 436 GLU GLU B . n 
B 2 141 TRP 141 437 437 TRP TRP B . n 
B 2 142 GLU 142 438 438 GLU GLU B . n 
B 2 143 ALA 143 439 439 ALA ALA B . n 
B 2 144 GLU 144 440 440 GLU GLU B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 XHT ? ? XHT ? ? 'SUBJECT OF INVESTIGATION' ? 
2 XHX ? ? XHX ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 XHT 1 901 901  XHT DRG A . 
D 4 XHX 1 902 1001 XHX DUB A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.18.2_3874: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9EL8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     121.485 
_cell.length_a_esd                 ? 
_cell.length_b                     178.279 
_cell.length_b_esd                 ? 
_cell.length_c                     234.613 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9EL8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9EL8 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             5.70 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          78.41 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1.2 Na/K Tartrate, 100 mM ADA pH 6.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            300 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-09-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.987 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE MASSIF-3' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.987 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MASSIF-3 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9EL8 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.90 
_reflns.d_resolution_low                               117.31 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     56035 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.97 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.133 
_reflns.pdbx_Rpim_I_all                                0.051 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       368602 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.122 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.90 
_reflns_shell.d_res_low                                     2.99 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           31040 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4481 
_reflns_shell.percent_possible_obs                          98.2 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.9 
_reflns_shell.pdbx_chi_squared                              0.56 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.0 
_reflns_shell.pdbx_Rrim_I_all                               1.945 
_reflns_shell.pdbx_Rpim_I_all                               0.731 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.568 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.800 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9EL8 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.91 
_refine.ls_d_res_low                             45.68 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     54108 
_refine.ls_number_reflns_R_free                  1983 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.22 
_refine.ls_percent_reflns_R_free                 3.66 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2155 
_refine.ls_R_factor_R_free                       0.2443 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2144 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.52 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        6286 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         95 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               6381 
_refine_hist.d_res_high                       2.91 
_refine_hist.d_res_low                        45.68 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.012  ? 6528 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.519  ? 8864 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 15.162 ? 943  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.075  ? 992  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.009  ? 1146 ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.91 2.98  . . 113 3012 81.00  . . . . 0.4342 . . . . . . . . . . . 0.4746 
'X-RAY DIFFRACTION' 2.98 3.06  . . 142 3700 99.00  . . . . 0.4037 . . . . . . . . . . . 0.4036 
'X-RAY DIFFRACTION' 3.06 3.15  . . 143 3750 100.00 . . . . 0.3646 . . . . . . . . . . . 0.4158 
'X-RAY DIFFRACTION' 3.15 3.25  . . 143 3739 100.00 . . . . 0.3322 . . . . . . . . . . . 0.3757 
'X-RAY DIFFRACTION' 3.25 3.37  . . 143 3764 100.00 . . . . 0.2928 . . . . . . . . . . . 0.3373 
'X-RAY DIFFRACTION' 3.37 3.50  . . 144 3767 100.00 . . . . 0.2825 . . . . . . . . . . . 0.2998 
'X-RAY DIFFRACTION' 3.50 3.66  . . 142 3737 100.00 . . . . 0.2493 . . . . . . . . . . . 0.2935 
'X-RAY DIFFRACTION' 3.66 3.86  . . 144 3791 100.00 . . . . 0.2284 . . . . . . . . . . . 0.2542 
'X-RAY DIFFRACTION' 3.86 4.10  . . 142 3747 99.00  . . . . 0.2125 . . . . . . . . . . . 0.2278 
'X-RAY DIFFRACTION' 4.10 4.41  . . 144 3760 99.00  . . . . 0.1931 . . . . . . . . . . . 0.2478 
'X-RAY DIFFRACTION' 4.41 4.86  . . 142 3786 100.00 . . . . 0.1844 . . . . . . . . . . . 0.2233 
'X-RAY DIFFRACTION' 4.86 5.56  . . 145 3808 100.00 . . . . 0.1977 . . . . . . . . . . . 0.2445 
'X-RAY DIFFRACTION' 5.56 7.00  . . 147 3853 100.00 . . . . 0.1961 . . . . . . . . . . . 0.2345 
'X-RAY DIFFRACTION' 7.00 45.68 . . 149 3911 98.00  . . . . 0.1533 . . . . . . . . . . . 0.1580 
# 
_struct.entry_id                     9EL8 
_struct.title                        'LSD1-CoREST in complex with T105 1S2R enantiomer' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9EL8 
_struct_keywords.text            'Epigenetics, Histone demethylase, Drug resistance, Covalent inhibitor, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP KDM1A_HUMAN O60341 ? 1 
;MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGS
AGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPP
EEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATF
RKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNV
LNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEF
TGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFV
PPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAG
EHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
;
1   
2 UNP RCOR1_HUMAN Q9UKL0 ? 2 
;RAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWT
TEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAE
;
308 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9EL8 A 20 ? 871 ? O60341 1   ? 852 ? 1   852 
2 2 9EL8 B 9  ? 144 ? Q9UKL0 308 ? 443 ? 305 440 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9EL8 GLY A 1  ? UNP O60341 ? ? 'expression tag' -18 1  
1 9EL8 SER A 2  ? UNP O60341 ? ? 'expression tag' -17 2  
1 9EL8 SER A 3  ? UNP O60341 ? ? 'expression tag' -16 3  
1 9EL8 HIS A 4  ? UNP O60341 ? ? 'expression tag' -15 4  
1 9EL8 HIS A 5  ? UNP O60341 ? ? 'expression tag' -14 5  
1 9EL8 HIS A 6  ? UNP O60341 ? ? 'expression tag' -13 6  
1 9EL8 HIS A 7  ? UNP O60341 ? ? 'expression tag' -12 7  
1 9EL8 HIS A 8  ? UNP O60341 ? ? 'expression tag' -11 8  
1 9EL8 HIS A 9  ? UNP O60341 ? ? 'expression tag' -10 9  
1 9EL8 SER A 10 ? UNP O60341 ? ? 'expression tag' -9  10 
1 9EL8 SER A 11 ? UNP O60341 ? ? 'expression tag' -8  11 
1 9EL8 GLY A 12 ? UNP O60341 ? ? 'expression tag' -7  12 
1 9EL8 LEU A 13 ? UNP O60341 ? ? 'expression tag' -6  13 
1 9EL8 VAL A 14 ? UNP O60341 ? ? 'expression tag' -5  14 
1 9EL8 PRO A 15 ? UNP O60341 ? ? 'expression tag' -4  15 
1 9EL8 ARG A 16 ? UNP O60341 ? ? 'expression tag' -3  16 
1 9EL8 GLY A 17 ? UNP O60341 ? ? 'expression tag' -2  17 
1 9EL8 SER A 18 ? UNP O60341 ? ? 'expression tag' -1  18 
1 9EL8 HIS A 19 ? UNP O60341 ? ? 'expression tag' 0   19 
2 9EL8 GLY B 1  ? UNP Q9UKL0 ? ? 'expression tag' 297 20 
2 9EL8 PRO B 2  ? UNP Q9UKL0 ? ? 'expression tag' 298 21 
2 9EL8 LEU B 3  ? UNP Q9UKL0 ? ? 'expression tag' 299 22 
2 9EL8 GLY B 4  ? UNP Q9UKL0 ? ? 'expression tag' 300 23 
2 9EL8 SER B 5  ? UNP Q9UKL0 ? ? 'expression tag' 301 24 
2 9EL8 PRO B 6  ? UNP Q9UKL0 ? ? 'expression tag' 302 25 
2 9EL8 GLU B 7  ? UNP Q9UKL0 ? ? 'expression tag' 303 26 
2 9EL8 PHE B 8  ? UNP Q9UKL0 ? ? 'expression tag' 304 27 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5390  ? 
1 MORE         -41   ? 
1 'SSA (A^2)'  37340 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 192 ? SER A 200 ? GLY A 173 SER A 181 1 ? 9  
HELX_P HELX_P2  AA2 THR A 208 ? PHE A 215 ? THR A 189 PHE A 196 1 ? 8  
HELX_P HELX_P3  AA3 PHE A 215 ? GLY A 221 ? PHE A 196 GLY A 202 1 ? 7  
HELX_P HELX_P4  AA4 PRO A 222 ? ASN A 243 ? PRO A 203 ASN A 224 1 ? 22 
HELX_P HELX_P5  AA5 THR A 249 ? LEU A 257 ? THR A 230 LEU A 238 1 ? 9  
HELX_P HELX_P6  AA6 PRO A 260 ? SER A 263 ? PRO A 241 SER A 244 5 ? 4  
HELX_P HELX_P7  AA7 ASP A 264 ? HIS A 278 ? ASP A 245 HIS A 259 1 ? 15 
HELX_P HELX_P8  AA8 GLY A 306 ? PHE A 319 ? GLY A 287 PHE A 300 1 ? 14 
HELX_P HELX_P9  AA9 ASN A 359 ? VAL A 368 ? ASN A 340 VAL A 349 1 ? 10 
HELX_P HELX_P10 AB1 PRO A 390 ? LEU A 415 ? PRO A 371 LEU A 396 1 ? 26 
HELX_P HELX_P11 AB2 SER A 426 ? VAL A 487 ? SER A 407 VAL A 468 1 ? 62 
HELX_P HELX_P12 AB3 ASP A 492 ? ASN A 533 ? ASP A 473 ASN A 514 1 ? 42 
HELX_P HELX_P13 AB4 SER A 541 ? ALA A 560 ? SER A 522 ALA A 541 1 ? 20 
HELX_P HELX_P14 AB5 ASP A 572 ? ASP A 576 ? ASP A 553 ASP A 557 5 ? 5  
HELX_P HELX_P15 AB6 SER A 591 ? ALA A 598 ? SER A 572 ALA A 579 1 ? 8  
HELX_P HELX_P16 AB7 PRO A 645 ? GLN A 651 ? PRO A 626 GLN A 632 1 ? 7  
HELX_P HELX_P17 AB8 PRO A 663 ? MET A 673 ? PRO A 644 MET A 654 1 ? 11 
HELX_P HELX_P18 AB9 THR A 703 ? ARG A 707 ? THR A 684 ARG A 688 5 ? 5  
HELX_P HELX_P19 AC1 ALA A 727 ? GLU A 735 ? ALA A 708 GLU A 716 1 ? 9  
HELX_P HELX_P20 AC2 SER A 738 ? GLY A 755 ? SER A 719 GLY A 736 1 ? 18 
HELX_P HELX_P21 AC3 SER A 756 ? VAL A 759 ? SER A 737 VAL A 740 5 ? 4  
HELX_P HELX_P22 AC4 SER A 788 ? GLN A 797 ? SER A 769 GLN A 778 1 ? 10 
HELX_P HELX_P23 AC5 THR A 829 ? LEU A 849 ? THR A 810 LEU A 830 1 ? 21 
HELX_P HELX_P24 AC6 ALA A 851 ? LEU A 855 ? ALA A 832 LEU A 836 5 ? 5  
HELX_P HELX_P25 AC7 SER B 21  ? ALA B 30  ? SER B 317 ALA B 326 1 ? 10 
HELX_P HELX_P26 AC8 THR B 33  ? LEU B 67  ? THR B 329 LEU B 363 1 ? 35 
HELX_P HELX_P27 AC9 ILE B 71  ? ARG B 75  ? ILE B 367 ARG B 371 5 ? 5  
HELX_P HELX_P28 AD1 THR B 88  ? GLY B 103 ? THR B 384 GLY B 399 1 ? 16 
HELX_P HELX_P29 AD2 ASP B 105 ? GLY B 114 ? ASP B 401 GLY B 410 1 ? 10 
HELX_P HELX_P30 AD3 SER B 117 ? TYR B 128 ? SER B 413 TYR B 424 1 ? 12 
HELX_P HELX_P31 AD4 ASN B 133 ? GLU B 144 ? ASN B 429 GLU B 440 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ALA 259 A . ? ALA 240 A PRO 260 A ? PRO 241 A 1 10.88 
2 PRO 489 A . ? PRO 470 A PRO 490 A ? PRO 471 A 1 24.47 
3 GLN 652 A . ? GLN 633 A PRO 653 A ? PRO 634 A 1 2.32  
4 VAL 659 A . ? VAL 640 A PRO 660 A ? PRO 641 A 1 4.62  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 3 ? 
AA4 ? 4 ? 
AA5 ? 2 ? 
AA6 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? parallel      
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 603 ? LYS A 604 ? ILE A 584 LYS A 585 
AA1 2 ASP A 322 ? LEU A 326 ? ASP A 303 LEU A 307 
AA1 3 LYS A 299 ? ILE A 303 ? LYS A 280 ILE A 284 
AA1 4 ALA A 639 ? CYS A 642 ? ALA A 620 CYS A 623 
AA1 5 LEU A 815 ? PHE A 817 ? LEU A 796 PHE A 798 
AA2 1 PHE A 339 ? LYS A 341 ? PHE A 320 LYS A 322 
AA2 2 TYR A 344 ? ALA A 346 ? TYR A 325 ALA A 327 
AA3 1 VAL A 352 ? VAL A 353 ? VAL A 333 VAL A 334 
AA3 2 LEU A 584 ? VAL A 586 ? LEU A 565 VAL A 567 
AA3 3 LEU A 372 ? LYS A 374 ? LEU A 353 LYS A 355 
AA4 1 THR A 632 ? CYS A 637 ? THR A 613 CYS A 618 
AA4 2 GLY A 618 ? ASN A 625 ? GLY A 599 ASN A 606 
AA4 3 THR A 607 ? THR A 615 ? THR A 588 THR A 596 
AA4 4 GLN A 657 ? VAL A 659 ? GLN A 638 VAL A 640 
AA5 1 GLY A 674 ? PHE A 675 ? GLY A 655 PHE A 656 
AA5 2 SER A 781 ? TYR A 782 ? SER A 762 TYR A 763 
AA6 1 LEU A 696 ? GLY A 698 ? LEU A 677 GLY A 679 
AA6 2 LEU A 712 ? ASN A 715 ? LEU A 693 ASN A 696 
AA6 3 ILE A 721 ? VAL A 726 ? ILE A 702 VAL A 707 
AA6 4 ASN A 679 ? CYS A 684 ? ASN A 660 CYS A 665 
AA6 5 GLU A 764 ? VAL A 767 ? GLU A 745 VAL A 748 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LYS A 604 ? O LYS A 585 N LEU A 325 ? N LEU A 306 
AA1 2 3 O ASP A 322 ? O ASP A 303 N VAL A 300 ? N VAL A 281 
AA1 3 4 N ILE A 303 ? N ILE A 284 O LEU A 641 ? O LEU A 622 
AA1 4 5 N CYS A 642 ? N CYS A 623 O PHE A 816 ? O PHE A 797 
AA2 1 2 N PHE A 339 ? N PHE A 320 O ALA A 346 ? O ALA A 327 
AA3 1 2 O VAL A 353 ? O VAL A 334 N LEU A 584 ? N LEU A 565 
AA3 2 3 O THR A 585 ? O THR A 566 N ALA A 373 ? N ALA A 354 
AA4 1 2 O PHE A 633 ? O PHE A 614 N ALA A 623 ? N ALA A 604 
AA4 2 3 O ILE A 622 ? O ILE A 603 N ARG A 610 ? N ARG A 591 
AA4 3 4 N VAL A 612 ? N VAL A 593 O VAL A 659 ? O VAL A 640 
AA5 1 2 N GLY A 674 ? N GLY A 655 O TYR A 782 ? O TYR A 763 
AA6 1 2 N PHE A 697 ? N PHE A 678 O PHE A 713 ? O PHE A 694 
AA6 2 3 N LEU A 712 ? N LEU A 693 O LEU A 725 ? O LEU A 706 
AA6 3 4 O ALA A 724 ? O ALA A 705 N VAL A 681 ? N VAL A 662 
AA6 4 5 N VAL A 682 ? N VAL A 663 O VAL A 766 ? O VAL A 747 
# 
_pdbx_entry_details.entry_id                   9EL8 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 CB  B SER 317 ? ? OD1 B ASP 320 ? ? 1.92 
2  1 O   A ASP 720 ? ? CG2 A VAL 724 ? ? 1.96 
3  1 NE2 B GLN 318 ? ? OE2 B GLU 322 ? ? 1.98 
4  1 CE2 B TYR 424 ? ? NH1 B ARG 427 ? ? 2.02 
5  1 CG1 A VAL 435 ? ? CD1 B ILE 349 ? ? 2.10 
6  1 OD2 A ASP 530 ? ? OG1 A THR 685 ? ? 2.15 
7  1 OE1 A GLU 645 ? ? OG  A SER 649 ? ? 2.16 
8  1 NZ  A LYS 421 ? ? OD2 B ASP 320 ? ? 2.16 
9  1 O   B ARG 382 ? ? NZ  B LYS 412 ? ? 2.19 
10 1 O   A PHE 666 ? ? CG  A PRO 701 ? ? 2.19 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CD 
_pdbx_validate_rmsd_bond.auth_asym_id_1            A 
_pdbx_validate_rmsd_bond.auth_comp_id_1            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_1             821 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            OE1 
_pdbx_validate_rmsd_bond.auth_asym_id_2            A 
_pdbx_validate_rmsd_bond.auth_comp_id_2            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_2             821 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.183 
_pdbx_validate_rmsd_bond.bond_target_value         1.252 
_pdbx_validate_rmsd_bond.bond_deviation            -0.069 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.011 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             GLU 
_pdbx_validate_rmsd_angle.auth_seq_id_1              510 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             GLU 
_pdbx_validate_rmsd_angle.auth_seq_id_2              510 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             C 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             GLU 
_pdbx_validate_rmsd_angle.auth_seq_id_3              510 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                97.09 
_pdbx_validate_rmsd_angle.angle_target_value         110.40 
_pdbx_validate_rmsd_angle.angle_deviation            -13.31 
_pdbx_validate_rmsd_angle.angle_standard_deviation   2.00 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN A 243 ? ? -95.57  44.69   
2  1 HIS A 259 ? ? -98.88  33.83   
3  1 ILE A 270 ? ? -70.89  -73.70  
4  1 SER A 286 ? ? -100.01 40.48   
5  1 MET A 332 ? ? -132.29 -31.03  
6  1 GLU A 352 ? ? -69.27  94.30   
7  1 ASN A 514 ? ? -115.62 61.46   
8  1 ALA A 541 ? ? 37.23   52.40   
9  1 LEU A 544 ? ? -59.71  -7.93   
10 1 LEU A 691 ? ? 37.89   56.15   
11 1 ALA A 708 ? ? -105.52 -169.98 
12 1 SER A 737 ? ? -39.38  -30.60  
13 1 ALA A 757 ? ? -135.15 -53.08  
14 1 SER A 760 ? ? -109.67 -66.91  
15 1 TYR A 807 ? ? -142.57 46.22   
16 1 ASN B 411 ? ? -162.39 -30.44  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY -18 ? A GLY 1   
2   1 Y 1 A SER -17 ? A SER 2   
3   1 Y 1 A SER -16 ? A SER 3   
4   1 Y 1 A HIS -15 ? A HIS 4   
5   1 Y 1 A HIS -14 ? A HIS 5   
6   1 Y 1 A HIS -13 ? A HIS 6   
7   1 Y 1 A HIS -12 ? A HIS 7   
8   1 Y 1 A HIS -11 ? A HIS 8   
9   1 Y 1 A HIS -10 ? A HIS 9   
10  1 Y 1 A SER -9  ? A SER 10  
11  1 Y 1 A SER -8  ? A SER 11  
12  1 Y 1 A GLY -7  ? A GLY 12  
13  1 Y 1 A LEU -6  ? A LEU 13  
14  1 Y 1 A VAL -5  ? A VAL 14  
15  1 Y 1 A PRO -4  ? A PRO 15  
16  1 Y 1 A ARG -3  ? A ARG 16  
17  1 Y 1 A GLY -2  ? A GLY 17  
18  1 Y 1 A SER -1  ? A SER 18  
19  1 Y 1 A HIS 0   ? A HIS 19  
20  1 Y 1 A MET 1   ? A MET 20  
21  1 Y 1 A LEU 2   ? A LEU 21  
22  1 Y 1 A SER 3   ? A SER 22  
23  1 Y 1 A GLY 4   ? A GLY 23  
24  1 Y 1 A LYS 5   ? A LYS 24  
25  1 Y 1 A LYS 6   ? A LYS 25  
26  1 Y 1 A ALA 7   ? A ALA 26  
27  1 Y 1 A ALA 8   ? A ALA 27  
28  1 Y 1 A ALA 9   ? A ALA 28  
29  1 Y 1 A ALA 10  ? A ALA 29  
30  1 Y 1 A ALA 11  ? A ALA 30  
31  1 Y 1 A ALA 12  ? A ALA 31  
32  1 Y 1 A ALA 13  ? A ALA 32  
33  1 Y 1 A ALA 14  ? A ALA 33  
34  1 Y 1 A ALA 15  ? A ALA 34  
35  1 Y 1 A ALA 16  ? A ALA 35  
36  1 Y 1 A ALA 17  ? A ALA 36  
37  1 Y 1 A ALA 18  ? A ALA 37  
38  1 Y 1 A THR 19  ? A THR 38  
39  1 Y 1 A GLY 20  ? A GLY 39  
40  1 Y 1 A THR 21  ? A THR 40  
41  1 Y 1 A GLU 22  ? A GLU 41  
42  1 Y 1 A ALA 23  ? A ALA 42  
43  1 Y 1 A GLY 24  ? A GLY 43  
44  1 Y 1 A PRO 25  ? A PRO 44  
45  1 Y 1 A GLY 26  ? A GLY 45  
46  1 Y 1 A THR 27  ? A THR 46  
47  1 Y 1 A ALA 28  ? A ALA 47  
48  1 Y 1 A GLY 29  ? A GLY 48  
49  1 Y 1 A GLY 30  ? A GLY 49  
50  1 Y 1 A SER 31  ? A SER 50  
51  1 Y 1 A GLU 32  ? A GLU 51  
52  1 Y 1 A ASN 33  ? A ASN 52  
53  1 Y 1 A GLY 34  ? A GLY 53  
54  1 Y 1 A SER 35  ? A SER 54  
55  1 Y 1 A GLU 36  ? A GLU 55  
56  1 Y 1 A VAL 37  ? A VAL 56  
57  1 Y 1 A ALA 38  ? A ALA 57  
58  1 Y 1 A ALA 39  ? A ALA 58  
59  1 Y 1 A GLN 40  ? A GLN 59  
60  1 Y 1 A PRO 41  ? A PRO 60  
61  1 Y 1 A ALA 42  ? A ALA 61  
62  1 Y 1 A GLY 43  ? A GLY 62  
63  1 Y 1 A LEU 44  ? A LEU 63  
64  1 Y 1 A SER 45  ? A SER 64  
65  1 Y 1 A GLY 46  ? A GLY 65  
66  1 Y 1 A PRO 47  ? A PRO 66  
67  1 Y 1 A ALA 48  ? A ALA 67  
68  1 Y 1 A GLU 49  ? A GLU 68  
69  1 Y 1 A VAL 50  ? A VAL 69  
70  1 Y 1 A GLY 51  ? A GLY 70  
71  1 Y 1 A PRO 52  ? A PRO 71  
72  1 Y 1 A GLY 53  ? A GLY 72  
73  1 Y 1 A ALA 54  ? A ALA 73  
74  1 Y 1 A VAL 55  ? A VAL 74  
75  1 Y 1 A GLY 56  ? A GLY 75  
76  1 Y 1 A GLU 57  ? A GLU 76  
77  1 Y 1 A ARG 58  ? A ARG 77  
78  1 Y 1 A THR 59  ? A THR 78  
79  1 Y 1 A PRO 60  ? A PRO 79  
80  1 Y 1 A ARG 61  ? A ARG 80  
81  1 Y 1 A LYS 62  ? A LYS 81  
82  1 Y 1 A LYS 63  ? A LYS 82  
83  1 Y 1 A GLU 64  ? A GLU 83  
84  1 Y 1 A PRO 65  ? A PRO 84  
85  1 Y 1 A PRO 66  ? A PRO 85  
86  1 Y 1 A ARG 67  ? A ARG 86  
87  1 Y 1 A ALA 68  ? A ALA 87  
88  1 Y 1 A SER 69  ? A SER 88  
89  1 Y 1 A PRO 70  ? A PRO 89  
90  1 Y 1 A PRO 71  ? A PRO 90  
91  1 Y 1 A GLY 72  ? A GLY 91  
92  1 Y 1 A GLY 73  ? A GLY 92  
93  1 Y 1 A LEU 74  ? A LEU 93  
94  1 Y 1 A ALA 75  ? A ALA 94  
95  1 Y 1 A GLU 76  ? A GLU 95  
96  1 Y 1 A PRO 77  ? A PRO 96  
97  1 Y 1 A PRO 78  ? A PRO 97  
98  1 Y 1 A GLY 79  ? A GLY 98  
99  1 Y 1 A SER 80  ? A SER 99  
100 1 Y 1 A ALA 81  ? A ALA 100 
101 1 Y 1 A GLY 82  ? A GLY 101 
102 1 Y 1 A PRO 83  ? A PRO 102 
103 1 Y 1 A GLN 84  ? A GLN 103 
104 1 Y 1 A ALA 85  ? A ALA 104 
105 1 Y 1 A GLY 86  ? A GLY 105 
106 1 Y 1 A PRO 87  ? A PRO 106 
107 1 Y 1 A THR 88  ? A THR 107 
108 1 Y 1 A VAL 89  ? A VAL 108 
109 1 Y 1 A VAL 90  ? A VAL 109 
110 1 Y 1 A PRO 91  ? A PRO 110 
111 1 Y 1 A GLY 92  ? A GLY 111 
112 1 Y 1 A SER 93  ? A SER 112 
113 1 Y 1 A ALA 94  ? A ALA 113 
114 1 Y 1 A THR 95  ? A THR 114 
115 1 Y 1 A PRO 96  ? A PRO 115 
116 1 Y 1 A MET 97  ? A MET 116 
117 1 Y 1 A GLU 98  ? A GLU 117 
118 1 Y 1 A THR 99  ? A THR 118 
119 1 Y 1 A GLY 100 ? A GLY 119 
120 1 Y 1 A ILE 101 ? A ILE 120 
121 1 Y 1 A ALA 102 ? A ALA 121 
122 1 Y 1 A GLU 103 ? A GLU 122 
123 1 Y 1 A THR 104 ? A THR 123 
124 1 Y 1 A PRO 105 ? A PRO 124 
125 1 Y 1 A GLU 106 ? A GLU 125 
126 1 Y 1 A GLY 107 ? A GLY 126 
127 1 Y 1 A ARG 108 ? A ARG 127 
128 1 Y 1 A ARG 109 ? A ARG 128 
129 1 Y 1 A THR 110 ? A THR 129 
130 1 Y 1 A SER 111 ? A SER 130 
131 1 Y 1 A ARG 112 ? A ARG 131 
132 1 Y 1 A ARG 113 ? A ARG 132 
133 1 Y 1 A LYS 114 ? A LYS 133 
134 1 Y 1 A ARG 115 ? A ARG 134 
135 1 Y 1 A ALA 116 ? A ALA 135 
136 1 Y 1 A LYS 117 ? A LYS 136 
137 1 Y 1 A VAL 118 ? A VAL 137 
138 1 Y 1 A GLU 119 ? A GLU 138 
139 1 Y 1 A TYR 120 ? A TYR 139 
140 1 Y 1 A ARG 121 ? A ARG 140 
141 1 Y 1 A GLU 122 ? A GLU 141 
142 1 Y 1 A MET 123 ? A MET 142 
143 1 Y 1 A ASP 124 ? A ASP 143 
144 1 Y 1 A GLU 125 ? A GLU 144 
145 1 Y 1 A SER 126 ? A SER 145 
146 1 Y 1 A LEU 127 ? A LEU 146 
147 1 Y 1 A ALA 128 ? A ALA 147 
148 1 Y 1 A ASN 129 ? A ASN 148 
149 1 Y 1 A LEU 130 ? A LEU 149 
150 1 Y 1 A SER 131 ? A SER 150 
151 1 Y 1 A GLU 132 ? A GLU 151 
152 1 Y 1 A ASP 133 ? A ASP 152 
153 1 Y 1 A GLU 134 ? A GLU 153 
154 1 Y 1 A TYR 135 ? A TYR 154 
155 1 Y 1 A TYR 136 ? A TYR 155 
156 1 Y 1 A SER 137 ? A SER 156 
157 1 Y 1 A GLU 138 ? A GLU 157 
158 1 Y 1 A GLU 139 ? A GLU 158 
159 1 Y 1 A GLU 140 ? A GLU 159 
160 1 Y 1 A ARG 141 ? A ARG 160 
161 1 Y 1 A ASN 142 ? A ASN 161 
162 1 Y 1 A ALA 143 ? A ALA 162 
163 1 Y 1 A LYS 144 ? A LYS 163 
164 1 Y 1 A ALA 145 ? A ALA 164 
165 1 Y 1 A GLU 146 ? A GLU 165 
166 1 Y 1 A LYS 147 ? A LYS 166 
167 1 Y 1 A GLU 148 ? A GLU 167 
168 1 Y 1 A LYS 149 ? A LYS 168 
169 1 Y 1 A LYS 150 ? A LYS 169 
170 1 Y 1 A LEU 151 ? A LEU 170 
171 1 Y 1 A PRO 152 ? A PRO 171 
172 1 Y 1 A PRO 153 ? A PRO 172 
173 1 Y 1 A PRO 154 ? A PRO 173 
174 1 Y 1 A PRO 155 ? A PRO 174 
175 1 Y 1 A PRO 156 ? A PRO 175 
176 1 Y 1 A GLN 157 ? A GLN 176 
177 1 Y 1 A ALA 158 ? A ALA 177 
178 1 Y 1 A PRO 159 ? A PRO 178 
179 1 Y 1 A PRO 160 ? A PRO 179 
180 1 Y 1 A GLU 161 ? A GLU 180 
181 1 Y 1 A GLU 162 ? A GLU 181 
182 1 Y 1 A GLU 163 ? A GLU 182 
183 1 Y 1 A ASN 164 ? A ASN 183 
184 1 Y 1 A GLU 165 ? A GLU 184 
185 1 Y 1 A SER 166 ? A SER 185 
186 1 Y 1 A GLU 167 ? A GLU 186 
187 1 Y 1 A PRO 168 ? A PRO 187 
188 1 Y 1 A GLU 169 ? A GLU 188 
189 1 Y 1 A GLU 170 ? A GLU 189 
190 1 Y 1 A PRO 171 ? A PRO 190 
191 1 Y 1 A PRO 837 ? A PRO 856 
192 1 Y 1 A ARG 838 ? A ARG 857 
193 1 Y 1 A GLN 839 ? A GLN 858 
194 1 Y 1 A ALA 840 ? A ALA 859 
195 1 Y 1 A THR 841 ? A THR 860 
196 1 Y 1 A PRO 842 ? A PRO 861 
197 1 Y 1 A GLY 843 ? A GLY 862 
198 1 Y 1 A VAL 844 ? A VAL 863 
199 1 Y 1 A PRO 845 ? A PRO 864 
200 1 Y 1 A ALA 846 ? A ALA 865 
201 1 Y 1 A GLN 847 ? A GLN 866 
202 1 Y 1 A GLN 848 ? A GLN 867 
203 1 Y 1 A SER 849 ? A SER 868 
204 1 Y 1 A PRO 850 ? A PRO 869 
205 1 Y 1 A SER 851 ? A SER 870 
206 1 Y 1 A MET 852 ? A MET 871 
207 1 Y 1 B GLY 297 ? B GLY 1   
208 1 Y 1 B PRO 298 ? B PRO 2   
209 1 Y 1 B LEU 299 ? B LEU 3   
210 1 Y 1 B GLY 300 ? B GLY 4   
211 1 Y 1 B SER 301 ? B SER 5   
212 1 Y 1 B PRO 302 ? B PRO 6   
213 1 Y 1 B GLU 303 ? B GLU 7   
214 1 Y 1 B PHE 304 ? B PHE 8   
215 1 Y 1 B ARG 305 ? B ARG 9   
216 1 Y 1 B ALA 306 ? B ALA 10  
217 1 Y 1 B LYS 307 ? B LYS 11  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
XHT C4   C N N 388 
XHT C14  C Y N 389 
XHT C5   C Y N 390 
XHT C6   C Y N 391 
XHT C11  C N N 392 
XHT C7   C Y N 393 
XHT C8   C Y N 394 
XHT C9   C Y N 395 
XHT C10  C N R 396 
XHT C12  C N R 397 
XHT C13  C Y N 398 
XHT N1   N Y N 399 
XHT N2   N Y N 400 
XHT C3   C Y N 401 
XHT N3   N N N 402 
XHT C1   C N N 403 
XHT C15  C Y N 404 
XHT C16  C N N 405 
XHT C17  C Y N 406 
XHT C18  C N N 407 
XHT C19  C Y N 408 
XHT C2   C Y N 409 
XHT C20  C Y N 410 
XHT C21  C N N 411 
XHT C22  C N S 412 
XHT C23  C N R 413 
XHT C24  C N S 414 
XHT C25  C N N 415 
XHT C26  C N N 416 
XHT C27  C N R 417 
XHT C28  C N R 418 
XHT C29  C Y N 419 
XHT C30  C Y N 420 
XHT C31  C Y N 421 
XHT C32  C Y N 422 
XHT C33  C Y N 423 
XHT C34  C N R 424 
XHT C35  C N S 425 
XHT C36  C N N 426 
XHT C37  C N N 427 
XHT C38  C N N 428 
XHT C39  C N S 429 
XHT C40  C Y N 430 
XHT N10  N Y N 431 
XHT N11  N N N 432 
XHT N12  N N N 433 
XHT N4   N N N 434 
XHT N5   N N N 435 
XHT N6   N Y N 436 
XHT N7   N Y N 437 
XHT N8   N N N 438 
XHT N9   N Y N 439 
XHT O1   O N N 440 
XHT O10  O N N 441 
XHT O11  O N N 442 
XHT O12  O N N 443 
XHT O13  O N N 444 
XHT O14  O N N 445 
XHT O15  O N N 446 
XHT O16  O N N 447 
XHT O17  O N N 448 
XHT O2   O N N 449 
XHT O3   O N N 450 
XHT O4   O N N 451 
XHT O5   O N N 452 
XHT O6   O N N 453 
XHT O7   O N N 454 
XHT O8   O N N 455 
XHT O9   O N N 456 
XHT P1   P N N 457 
XHT P2   P N N 458 
XHT S1   S Y N 459 
XHT H1   H N N 460 
XHT H2   H N N 461 
XHT H3   H N N 462 
XHT H4   H N N 463 
XHT H5   H N N 464 
XHT H6   H N N 465 
XHT H7   H N N 466 
XHT H8   H N N 467 
XHT H9   H N N 468 
XHT H10  H N N 469 
XHT H11  H N N 470 
XHT H12  H N N 471 
XHT H13  H N N 472 
XHT H14  H N N 473 
XHT H15  H N N 474 
XHT H16  H N N 475 
XHT H17  H N N 476 
XHT H18  H N N 477 
XHT H19  H N N 478 
XHT H20  H N N 479 
XHT H21  H N N 480 
XHT H22  H N N 481 
XHT H23  H N N 482 
XHT H24  H N N 483 
XHT H25  H N N 484 
XHT H26  H N N 485 
XHT H27  H N N 486 
XHT H28  H N N 487 
XHT H29  H N N 488 
XHT H30  H N N 489 
XHT H31  H N N 490 
XHT H32  H N N 491 
XHT H33  H N N 492 
XHT H34  H N N 493 
XHT H36  H N N 494 
XHT H38  H N N 495 
XHT H39  H N N 496 
XHT H40  H N N 497 
XHT H41  H N N 498 
XHT H42  H N N 499 
XHT H43  H N N 500 
XHT H44  H N N 501 
XHT H45  H N N 502 
XHT H46  H N N 503 
XHT H47  H N N 504 
XHT H48  H N N 505 
XHX C1   C N N 506 
XHX C10  C N R 507 
XHX C11  C N N 508 
XHX C12  C N S 509 
XHX C13  C N N 510 
XHX C14  C N N 511 
XHX C15  C N N 512 
XHX C16  C N N 513 
XHX C17  C Y N 514 
XHX C2   C Y N 515 
XHX C3   C Y N 516 
XHX C4   C N N 517 
XHX C5   C Y N 518 
XHX C6   C Y N 519 
XHX C7   C Y N 520 
XHX C8   C Y N 521 
XHX C9   C Y N 522 
XHX N1   N Y N 523 
XHX N2   N Y N 524 
XHX N3   N N N 525 
XHX N4   N N N 526 
XHX O1   O N N 527 
XHX S1   S Y N 528 
XHX H1   H N N 529 
XHX H2   H N N 530 
XHX H3   H N N 531 
XHX H4   H N N 532 
XHX H5   H N N 533 
XHX H6   H N N 534 
XHX H7   H N N 535 
XHX H8   H N N 536 
XHX H9   H N N 537 
XHX H10  H N N 538 
XHX H11  H N N 539 
XHX H12  H N N 540 
XHX H13  H N N 541 
XHX H14  H N N 542 
XHX H15  H N N 543 
XHX H18  H N N 544 
XHX H19  H N N 545 
XHX H20  H N N 546 
XHX H23  H N N 547 
XHX H24  H N N 548 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
XHT N1  C2   doub Y N 374 
XHT N1  N2   sing Y N 375 
XHT C1  C2   sing N N 376 
XHT C2  S1   sing Y N 377 
XHT N2  C3   doub Y N 378 
XHT C16 C15  sing N N 379 
XHT O1  C4   doub N N 380 
XHT O2  C12  sing N N 381 
XHT C3  S1   sing Y N 382 
XHT C3  N3   sing N N 383 
XHT C15 C14  doub Y N 384 
XHT C15 C17  sing Y N 385 
XHT C14 C13  sing Y N 386 
XHT C12 C11  sing N N 387 
XHT C12 N4   sing N N 388 
XHT C4  N3   sing N N 389 
XHT C4  C5   sing N N 390 
XHT C11 C10  sing N N 391 
XHT C18 C17  sing N N 392 
XHT C17 C19  doub Y N 393 
XHT C13 N4   sing N N 394 
XHT C13 C20  doub Y N 395 
XHT N4  C39  sing N N 396 
XHT C40 C5   doub Y N 397 
XHT C40 C9   sing Y N 398 
XHT C5  C6   sing Y N 399 
XHT O17 C38  doub N N 400 
XHT C10 C39  sing N N 401 
XHT C10 C9   sing N N 402 
XHT C19 C20  sing Y N 403 
XHT C20 N5   sing N N 404 
XHT C39 C38  sing N N 405 
XHT C39 C36  sing N N 406 
XHT C9  C8   doub Y N 407 
XHT C38 N12  sing N N 408 
XHT C6  C7   doub Y N 409 
XHT N5  C36  sing N N 410 
XHT N5  C21  sing N N 411 
XHT C36 N11  doub N N 412 
XHT C8  C7   sing Y N 413 
XHT N12 C37  sing N N 414 
XHT O3  C22  sing N N 415 
XHT C21 C22  sing N N 416 
XHT N11 C37  sing N N 417 
XHT C37 O16  doub N N 418 
XHT C22 C23  sing N N 419 
XHT O14 C34  sing N N 420 
XHT C34 C35  sing N N 421 
XHT C34 C28  sing N N 422 
XHT O11 P2   doub N N 423 
XHT C23 C24  sing N N 424 
XHT C23 O4   sing N N 425 
XHT C24 O5   sing N N 426 
XHT C24 C25  sing N N 427 
XHT C29 N7   doub Y N 428 
XHT C29 N6   sing Y N 429 
XHT C35 O15  sing N N 430 
XHT C35 C27  sing N N 431 
XHT O10 P2   sing N N 432 
XHT N7  C30  sing Y N 433 
XHT P2  O12  sing N N 434 
XHT P2  O9   sing N N 435 
XHT N6  C28  sing N N 436 
XHT N6  C33  sing Y N 437 
XHT C28 O13  sing N N 438 
XHT C25 O6   sing N N 439 
XHT C30 C33  doub Y N 440 
XHT C30 C31  sing Y N 441 
XHT N8  C31  sing N N 442 
XHT C33 N10  sing Y N 443 
XHT C31 N9   doub Y N 444 
XHT O12 C26  sing N N 445 
XHT C27 O13  sing N N 446 
XHT C27 C26  sing N N 447 
XHT O9  P1   sing N N 448 
XHT O6  P1   sing N N 449 
XHT N10 C32  doub Y N 450 
XHT N9  C32  sing Y N 451 
XHT P1  O8   doub N N 452 
XHT P1  O7   sing N N 453 
XHT C14 H1   sing N N 454 
XHT C6  H2   sing N N 455 
XHT C11 H3   sing N N 456 
XHT C11 H4   sing N N 457 
XHT C7  H5   sing N N 458 
XHT C8  H6   sing N N 459 
XHT C10 H7   sing N N 460 
XHT C12 H8   sing N N 461 
XHT N3  H9   sing N N 462 
XHT C1  H10  sing N N 463 
XHT C1  H11  sing N N 464 
XHT C1  H12  sing N N 465 
XHT C16 H13  sing N N 466 
XHT C16 H14  sing N N 467 
XHT C16 H15  sing N N 468 
XHT C18 H16  sing N N 469 
XHT C18 H17  sing N N 470 
XHT C18 H18  sing N N 471 
XHT C19 H19  sing N N 472 
XHT C21 H20  sing N N 473 
XHT C21 H21  sing N N 474 
XHT C22 H22  sing N N 475 
XHT C23 H23  sing N N 476 
XHT C24 H24  sing N N 477 
XHT C25 H25  sing N N 478 
XHT C25 H26  sing N N 479 
XHT C26 H27  sing N N 480 
XHT C26 H28  sing N N 481 
XHT C27 H29  sing N N 482 
XHT C28 H30  sing N N 483 
XHT C29 H31  sing N N 484 
XHT C32 H32  sing N N 485 
XHT C34 H33  sing N N 486 
XHT C35 H34  sing N N 487 
XHT C40 H36  sing N N 488 
XHT N12 H38  sing N N 489 
XHT N8  H39  sing N N 490 
XHT N8  H40  sing N N 491 
XHT O10 H41  sing N N 492 
XHT O14 H42  sing N N 493 
XHT O15 H43  sing N N 494 
XHT O2  H44  sing N N 495 
XHT O3  H45  sing N N 496 
XHT O4  H46  sing N N 497 
XHT O5  H47  sing N N 498 
XHT O7  H48  sing N N 499 
XHX S1  C2   sing Y N 500 
XHX S1  C3   sing Y N 501 
XHX C1  C2   sing N N 502 
XHX C2  N1   doub Y N 503 
XHX C7  C6   doub Y N 504 
XHX C7  C8   sing Y N 505 
XHX C6  C5   sing Y N 506 
XHX C3  N3   sing N N 507 
XHX C3  N2   doub Y N 508 
XHX N3  C4   sing N N 509 
XHX N1  N2   sing Y N 510 
XHX C8  C9   doub Y N 511 
XHX C5  C4   sing N N 512 
XHX C5  C17  doub Y N 513 
XHX C4  O1   doub N N 514 
XHX C9  C17  sing Y N 515 
XHX C9  C10  sing N N 516 
XHX C14 C13  sing N N 517 
XHX C14 C15  sing N N 518 
XHX C10 C12  sing N N 519 
XHX C10 C11  sing N N 520 
XHX C13 N4   sing N N 521 
XHX C13 C16  sing N N 522 
XHX C12 N4   sing N N 523 
XHX C12 C11  sing N N 524 
XHX C15 C16  sing N N 525 
XHX C1  H1   sing N N 526 
XHX C1  H2   sing N N 527 
XHX C1  H3   sing N N 528 
XHX C10 H4   sing N N 529 
XHX C11 H5   sing N N 530 
XHX C11 H6   sing N N 531 
XHX C12 H7   sing N N 532 
XHX C13 H8   sing N N 533 
XHX C14 H9   sing N N 534 
XHX C14 H10  sing N N 535 
XHX C15 H11  sing N N 536 
XHX C15 H12  sing N N 537 
XHX C16 H13  sing N N 538 
XHX C16 H14  sing N N 539 
XHX C17 H15  sing N N 540 
XHX C6  H18  sing N N 541 
XHX C7  H19  sing N N 542 
XHX C8  H20  sing N N 543 
XHX N3  H23  sing N N 544 
XHX N4  H24  sing N N 545 
# 
_pdbx_audit_support.funding_organization   'Italian Association for Cancer Research' 
_pdbx_audit_support.country                Italy 
_pdbx_audit_support.grant_number           IG19808 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2v1d 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9EL8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008231 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005609 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.004262 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 191 ? -17.784 37.980  100.903 1.00 141.82 ? 172 SER A N   1 
ATOM   2    C CA  . SER A 1 191 ? -19.139 38.242  101.384 1.00 136.89 ? 172 SER A CA  1 
ATOM   3    C C   . SER A 1 191 ? -19.185 38.329  102.910 1.00 126.66 ? 172 SER A C   1 
ATOM   4    O O   . SER A 1 191 ? -18.356 37.747  103.624 1.00 120.93 ? 172 SER A O   1 
ATOM   5    C CB  . SER A 1 191 ? -20.124 37.161  100.898 1.00 139.81 ? 172 SER A CB  1 
ATOM   6    O OG  . SER A 1 191 ? -20.177 36.048  101.787 1.00 133.23 ? 172 SER A OG  1 
ATOM   7    N N   . GLY A 1 192 ? -20.195 39.045  103.398 1.00 118.47 ? 173 GLY A N   1 
ATOM   8    C CA  . GLY A 1 192 ? -20.437 39.141  104.825 1.00 122.69 ? 173 GLY A CA  1 
ATOM   9    C C   . GLY A 1 192 ? -19.920 40.441  105.403 1.00 114.17 ? 173 GLY A C   1 
ATOM   10   O O   . GLY A 1 192 ? -19.957 41.474  104.727 1.00 107.45 ? 173 GLY A O   1 
ATOM   11   N N   . VAL A 1 193 ? -19.441 40.419  106.652 1.00 110.39 ? 174 VAL A N   1 
ATOM   12   C CA  . VAL A 1 193 ? -18.707 41.583  107.121 1.00 99.23  ? 174 VAL A CA  1 
ATOM   13   C C   . VAL A 1 193 ? -17.385 41.658  106.383 1.00 101.81 ? 174 VAL A C   1 
ATOM   14   O O   . VAL A 1 193 ? -16.935 42.739  105.998 1.00 107.46 ? 174 VAL A O   1 
ATOM   15   C CB  . VAL A 1 193 ? -18.488 41.563  108.651 1.00 100.79 ? 174 VAL A CB  1 
ATOM   16   C CG1 . VAL A 1 193 ? -19.805 41.364  109.402 1.00 107.16 ? 174 VAL A CG1 1 
ATOM   17   C CG2 . VAL A 1 193 ? -17.356 40.623  109.101 1.00 104.09 ? 174 VAL A CG2 1 
ATOM   18   N N   . GLU A 1 194 ? -16.777 40.501  106.111 1.00 102.81 ? 175 GLU A N   1 
ATOM   19   C CA  . GLU A 1 194 ? -15.463 40.475  105.482 1.00 105.86 ? 175 GLU A CA  1 
ATOM   20   C C   . GLU A 1 194 ? -15.489 41.093  104.086 1.00 105.08 ? 175 GLU A C   1 
ATOM   21   O O   . GLU A 1 194 ? -14.482 41.658  103.637 1.00 100.47 ? 175 GLU A O   1 
ATOM   22   C CB  . GLU A 1 194 ? -14.967 39.034  105.416 1.00 112.25 ? 175 GLU A CB  1 
ATOM   23   C CG  . GLU A 1 194 ? -15.181 38.268  106.705 1.00 115.24 ? 175 GLU A CG  1 
ATOM   24   C CD  . GLU A 1 194 ? -14.821 36.792  106.587 1.00 124.61 ? 175 GLU A CD  1 
ATOM   25   O OE1 . GLU A 1 194 ? -15.047 36.060  107.579 1.00 126.90 ? 175 GLU A OE1 1 
ATOM   26   O OE2 . GLU A 1 194 ? -14.322 36.370  105.510 1.00 118.26 ? 175 GLU A OE2 1 
ATOM   27   N N   . GLY A 1 195 ? -16.618 40.984  103.379 1.00 106.48 ? 176 GLY A N   1 
ATOM   28   C CA  . GLY A 1 195 ? -16.716 41.616  102.077 1.00 102.40 ? 176 GLY A CA  1 
ATOM   29   C C   . GLY A 1 195 ? -16.494 43.110  102.162 1.00 95.20  ? 176 GLY A C   1 
ATOM   30   O O   . GLY A 1 195 ? -15.850 43.706  101.295 1.00 91.77  ? 176 GLY A O   1 
ATOM   31   N N   . ALA A 1 196 ? -16.990 43.726  103.235 1.00 99.05  ? 177 ALA A N   1 
ATOM   32   C CA  . ALA A 1 196 ? -16.856 45.168  103.388 1.00 94.32  ? 177 ALA A CA  1 
ATOM   33   C C   . ALA A 1 196 ? -15.416 45.586  103.658 1.00 87.55  ? 177 ALA A C   1 
ATOM   34   O O   . ALA A 1 196 ? -15.013 46.685  103.263 1.00 90.71  ? 177 ALA A O   1 
ATOM   35   C CB  . ALA A 1 196 ? -17.771 45.658  104.503 1.00 92.10  ? 177 ALA A CB  1 
ATOM   36   N N   . ALA A 1 197 ? -14.629 44.746  104.329 1.00 83.81  ? 178 ALA A N   1 
ATOM   37   C CA  . ALA A 1 197 ? -13.215 45.068  104.497 1.00 87.83  ? 178 ALA A CA  1 
ATOM   38   C C   . ALA A 1 197 ? -12.485 45.030  103.155 1.00 89.13  ? 178 ALA A C   1 
ATOM   39   O O   . ALA A 1 197 ? -11.713 45.940  102.816 1.00 79.34  ? 178 ALA A O   1 
ATOM   40   C CB  . ALA A 1 197 ? -12.572 44.109  105.502 1.00 79.95  ? 178 ALA A CB  1 
ATOM   41   N N   . PHE A 1 198 ? -12.722 43.975  102.378 1.00 88.15  ? 179 PHE A N   1 
ATOM   42   C CA  . PHE A 1 198 ? -12.156 43.903  101.044 1.00 84.39  ? 179 PHE A CA  1 
ATOM   43   C C   . PHE A 1 198 ? -12.638 45.075  100.186 1.00 85.07  ? 179 PHE A C   1 
ATOM   44   O O   . PHE A 1 198 ? -11.860 45.670  99.426  1.00 83.39  ? 179 PHE A O   1 
ATOM   45   C CB  . PHE A 1 198 ? -12.523 42.549  100.422 1.00 87.32  ? 179 PHE A CB  1 
ATOM   46   C CG  . PHE A 1 198 ? -12.232 42.462  98.967  1.00 88.26  ? 179 PHE A CG  1 
ATOM   47   C CD1 . PHE A 1 198 ? -10.998 42.009  98.529  1.00 84.78  ? 179 PHE A CD1 1 
ATOM   48   C CD2 . PHE A 1 198 ? -13.179 42.864  98.035  1.00 84.64  ? 179 PHE A CD2 1 
ATOM   49   C CE1 . PHE A 1 198 ? -10.713 41.952  97.195  1.00 87.80  ? 179 PHE A CE1 1 
ATOM   50   C CE2 . PHE A 1 198 ? -12.900 42.824  96.697  1.00 89.20  ? 179 PHE A CE2 1 
ATOM   51   C CZ  . PHE A 1 198 ? -11.669 42.361  96.270  1.00 93.39  ? 179 PHE A CZ  1 
ATOM   52   N N   . GLN A 1 199 ? -13.918 45.424  100.295 1.00 80.11  ? 180 GLN A N   1 
ATOM   53   C CA  . GLN A 1 199 ? -14.463 46.511  99.500  1.00 79.02  ? 180 GLN A CA  1 
ATOM   54   C C   . GLN A 1 199 ? -13.941 47.869  99.959  1.00 84.84  ? 180 GLN A C   1 
ATOM   55   O O   . GLN A 1 199 ? -14.100 48.872  99.250  1.00 88.09  ? 180 GLN A O   1 
ATOM   56   C CB  . GLN A 1 199 ? -15.992 46.417  99.556  1.00 83.68  ? 180 GLN A CB  1 
ATOM   57   C CG  . GLN A 1 199 ? -16.804 47.508  98.856  1.00 86.66  ? 180 GLN A CG  1 
ATOM   58   C CD  . GLN A 1 199 ? -16.327 47.824  97.448  1.00 90.46  ? 180 GLN A CD  1 
ATOM   59   O OE1 . GLN A 1 199 ? -15.951 46.931  96.684  1.00 83.25  ? 180 GLN A OE1 1 
ATOM   60   N NE2 . GLN A 1 199 ? -16.332 49.120  97.102  1.00 93.28  ? 180 GLN A NE2 1 
ATOM   61   N N   . SER A 1 200 ? -13.285 47.922  101.113 1.00 88.94  ? 181 SER A N   1 
ATOM   62   C CA  . SER A 1 200 ? -12.675 49.139  101.627 1.00 83.43  ? 181 SER A CA  1 
ATOM   63   C C   . SER A 1 200 ? -11.150 49.065  101.582 1.00 79.18  ? 181 SER A C   1 
ATOM   64   O O   . SER A 1 200 ? -10.477 49.755  102.350 1.00 83.08  ? 181 SER A O   1 
ATOM   65   C CB  . SER A 1 200 ? -13.174 49.397  103.056 1.00 85.08  ? 181 SER A CB  1 
ATOM   66   O OG  . SER A 1 200 ? -14.537 49.816  103.080 1.00 81.80  ? 181 SER A OG  1 
ATOM   67   N N   . ARG A 1 201 ? -10.596 48.209  100.724 1.00 77.73  ? 182 ARG A N   1 
ATOM   68   C CA  . ARG A 1 201 ? -9.151  48.039  100.561 1.00 66.71  ? 182 ARG A CA  1 
ATOM   69   C C   . ARG A 1 201 ? -8.465  47.589  101.851 1.00 70.62  ? 182 ARG A C   1 
ATOM   70   O O   . ARG A 1 201 ? -7.292  47.898  102.055 1.00 70.70  ? 182 ARG A O   1 
ATOM   71   C CB  . ARG A 1 201 ? -8.488  49.329  100.088 1.00 74.60  ? 182 ARG A CB  1 
ATOM   72   C CG  . ARG A 1 201 ? -8.704  49.755  98.663  1.00 70.57  ? 182 ARG A CG  1 
ATOM   73   C CD  . ARG A 1 201 ? -9.986  50.501  98.522  1.00 72.12  ? 182 ARG A CD  1 
ATOM   74   N NE  . ARG A 1 201 ? -9.998  51.671  99.372  1.00 77.48  ? 182 ARG A NE  1 
ATOM   75   C CZ  . ARG A 1 201 ? -11.091 52.380  99.619  1.00 85.69  ? 182 ARG A CZ  1 
ATOM   76   N NH1 . ARG A 1 201 ? -12.241 52.055  99.035  1.00 88.94  ? 182 ARG A NH1 1 
ATOM   77   N NH2 . ARG A 1 201 ? -11.032 53.419  100.444 1.00 89.03  ? 182 ARG A NH2 1 
ATOM   78   N N   . LEU A 1 202 ? -9.164  46.848  102.733 1.00 75.94  ? 183 LEU A N   1 
ATOM   79   C CA  . LEU A 1 202 ? -8.657  46.550  104.081 1.00 76.14  ? 183 LEU A CA  1 
ATOM   80   C C   . LEU A 1 202 ? -8.659  45.062  104.411 1.00 73.68  ? 183 LEU A C   1 
ATOM   81   O O   . LEU A 1 202 ? -9.655  44.371  104.161 1.00 78.26  ? 183 LEU A O   1 
ATOM   82   C CB  . LEU A 1 202 ? -9.512  47.251  105.149 1.00 79.88  ? 183 LEU A CB  1 
ATOM   83   C CG  . LEU A 1 202 ? -9.498  48.763  105.317 1.00 76.27  ? 183 LEU A CG  1 
ATOM   84   C CD1 . LEU A 1 202 ? -10.835 49.195  105.894 1.00 74.83  ? 183 LEU A CD1 1 
ATOM   85   C CD2 . LEU A 1 202 ? -8.364  49.157  106.220 1.00 81.06  ? 183 LEU A CD2 1 
ATOM   86   N N   . PRO A 1 203 ? -7.590  44.553  105.028 1.00 70.42  ? 184 PRO A N   1 
ATOM   87   C CA  . PRO A 1 203 ? -7.602  43.165  105.510 1.00 76.05  ? 184 PRO A CA  1 
ATOM   88   C C   . PRO A 1 203 ? -8.648  42.975  106.590 1.00 83.80  ? 184 PRO A C   1 
ATOM   89   O O   . PRO A 1 203 ? -8.650  43.677  107.602 1.00 86.30  ? 184 PRO A O   1 
ATOM   90   C CB  . PRO A 1 203 ? -6.190  42.961  106.070 1.00 74.15  ? 184 PRO A CB  1 
ATOM   91   C CG  . PRO A 1 203 ? -5.685  44.266  106.324 1.00 72.58  ? 184 PRO A CG  1 
ATOM   92   C CD  . PRO A 1 203 ? -6.321  45.212  105.333 1.00 71.93  ? 184 PRO A CD  1 
ATOM   93   N N   . HIS A 1 204 ? -9.528  41.996  106.386 1.00 90.75  ? 185 HIS A N   1 
ATOM   94   C CA  . HIS A 1 204 ? -10.626 41.808  107.326 1.00 87.98  ? 185 HIS A CA  1 
ATOM   95   C C   . HIS A 1 204 ? -10.196 41.209  108.651 1.00 84.25  ? 185 HIS A C   1 
ATOM   96   O O   . HIS A 1 204 ? -10.972 41.286  109.604 1.00 92.28  ? 185 HIS A O   1 
ATOM   97   C CB  . HIS A 1 204 ? -11.705 40.919  106.720 1.00 95.77  ? 185 HIS A CB  1 
ATOM   98   C CG  . HIS A 1 204 ? -11.258 39.511  106.492 1.00 103.92 ? 185 HIS A CG  1 
ATOM   99   N ND1 . HIS A 1 204 ? -11.438 38.513  107.425 1.00 99.67  ? 185 HIS A ND1 1 
ATOM   100  C CD2 . HIS A 1 204 ? -10.640 38.933  105.435 1.00 107.17 ? 185 HIS A CD2 1 
ATOM   101  C CE1 . HIS A 1 204 ? -10.948 37.382  106.954 1.00 101.65 ? 185 HIS A CE1 1 
ATOM   102  N NE2 . HIS A 1 204 ? -10.460 37.608  105.747 1.00 104.26 ? 185 HIS A NE2 1 
ATOM   103  N N   . ASP A 1 205 ? -8.994  40.640  108.752 1.00 83.83  ? 186 ASP A N   1 
ATOM   104  C CA  . ASP A 1 205 ? -8.603  39.857  109.921 1.00 86.74  ? 186 ASP A CA  1 
ATOM   105  C C   . ASP A 1 205 ? -7.304  40.327  110.551 1.00 84.65  ? 186 ASP A C   1 
ATOM   106  O O   . ASP A 1 205 ? -6.706  39.595  111.347 1.00 80.52  ? 186 ASP A O   1 
ATOM   107  C CB  . ASP A 1 205 ? -8.460  38.389  109.537 1.00 97.27  ? 186 ASP A CB  1 
ATOM   108  C CG  . ASP A 1 205 ? -7.628  38.205  108.283 1.00 103.33 ? 186 ASP A CG  1 
ATOM   109  O OD1 . ASP A 1 205 ? -6.665  38.984  108.063 1.00 101.90 ? 186 ASP A OD1 1 
ATOM   110  O OD2 . ASP A 1 205 ? -7.960  37.288  107.502 1.00 109.47 ? 186 ASP A OD2 1 
ATOM   111  N N   . ARG A 1 206 ? -6.827  41.496  110.176 1.00 89.31  ? 187 ARG A N   1 
ATOM   112  C CA  . ARG A 1 206 ? -5.604  42.062  110.706 1.00 89.86  ? 187 ARG A CA  1 
ATOM   113  C C   . ARG A 1 206 ? -5.862  43.557  110.783 1.00 88.45  ? 187 ARG A C   1 
ATOM   114  O O   . ARG A 1 206 ? -6.698  44.081  110.038 1.00 82.74  ? 187 ARG A O   1 
ATOM   115  C CB  . ARG A 1 206 ? -4.421  41.679  109.794 1.00 89.64  ? 187 ARG A CB  1 
ATOM   116  C CG  . ARG A 1 206 ? -3.093  42.417  109.962 1.00 100.55 ? 187 ARG A CG  1 
ATOM   117  C CD  . ARG A 1 206 ? -1.998  41.724  109.115 1.00 98.98  ? 187 ARG A CD  1 
ATOM   118  N NE  . ARG A 1 206 ? -1.932  42.304  107.771 1.00 105.34 ? 187 ARG A NE  1 
ATOM   119  C CZ  . ARG A 1 206 ? -2.685  41.899  106.747 1.00 103.64 ? 187 ARG A CZ  1 
ATOM   120  N NH1 . ARG A 1 206 ? -2.564  42.479  105.555 1.00 93.57  ? 187 ARG A NH1 1 
ATOM   121  N NH2 . ARG A 1 206 ? -3.571  40.919  106.919 1.00 98.76  ? 187 ARG A NH2 1 
ATOM   122  N N   . MET A 1 207 ? -5.219  44.239  111.725 1.00 86.03  ? 188 MET A N   1 
ATOM   123  C CA  . MET A 1 207 ? -5.374  45.683  111.786 1.00 80.54  ? 188 MET A CA  1 
ATOM   124  C C   . MET A 1 207 ? -4.255  46.350  110.997 1.00 80.60  ? 188 MET A C   1 
ATOM   125  O O   . MET A 1 207 ? -3.108  45.884  111.012 1.00 82.41  ? 188 MET A O   1 
ATOM   126  C CB  . MET A 1 207 ? -5.402  46.195  113.223 1.00 84.57  ? 188 MET A CB  1 
ATOM   127  C CG  . MET A 1 207 ? -6.628  45.747  114.019 1.00 91.49  ? 188 MET A CG  1 
ATOM   128  S SD  . MET A 1 207 ? -6.785  46.631  115.610 1.00 97.58  ? 188 MET A SD  1 
ATOM   129  C CE  . MET A 1 207 ? -5.121  46.620  116.107 1.00 73.38  ? 188 MET A CE  1 
ATOM   130  N N   . THR A 1 208 ? -4.609  47.420  110.279 1.00 78.04  ? 189 THR A N   1 
ATOM   131  C CA  . THR A 1 208 ? -3.655  48.102  109.417 1.00 74.45  ? 189 THR A CA  1 
ATOM   132  C C   . THR A 1 208 ? -2.728  48.973  110.246 1.00 72.47  ? 189 THR A C   1 
ATOM   133  O O   . THR A 1 208 ? -2.943  49.201  111.431 1.00 77.82  ? 189 THR A O   1 
ATOM   134  C CB  . THR A 1 208 ? -4.362  48.948  108.345 1.00 75.41  ? 189 THR A CB  1 
ATOM   135  O OG1 . THR A 1 208 ? -4.986  50.106  108.919 1.00 75.72  ? 189 THR A OG1 1 
ATOM   136  C CG2 . THR A 1 208 ? -5.399  48.138  107.638 1.00 73.12  ? 189 THR A CG2 1 
ATOM   137  N N   . SER A 1 209 ? -1.683  49.472  109.598 1.00 77.85  ? 190 SER A N   1 
ATOM   138  C CA  . SER A 1 209 ? -0.788  50.408  110.264 1.00 79.21  ? 190 SER A CA  1 
ATOM   139  C C   . SER A 1 209 ? -1.524  51.708  110.618 1.00 80.60  ? 190 SER A C   1 
ATOM   140  O O   . SER A 1 209 ? -1.242  52.321  111.664 1.00 72.35  ? 190 SER A O   1 
ATOM   141  C CB  . SER A 1 209 ? 0.429   50.661  109.369 1.00 81.28  ? 190 SER A CB  1 
ATOM   142  O OG  . SER A 1 209 ? 1.345   51.581  109.924 1.00 83.90  ? 190 SER A OG  1 
ATOM   143  N N   . GLN A 1 210 ? -2.482  52.136  109.767 1.00 82.33  ? 191 GLN A N   1 
ATOM   144  C CA  . GLN A 1 210 ? -3.406  53.220  110.117 1.00 81.14  ? 191 GLN A CA  1 
ATOM   145  C C   . GLN A 1 210 ? -3.924  53.034  111.540 1.00 81.38  ? 191 GLN A C   1 
ATOM   146  O O   . GLN A 1 210 ? -3.824  53.919  112.394 1.00 79.18  ? 191 GLN A O   1 
ATOM   147  C CB  . GLN A 1 210 ? -4.656  53.224  109.224 1.00 87.33  ? 191 GLN A CB  1 
ATOM   148  C CG  . GLN A 1 210 ? -5.491  54.487  109.431 1.00 89.94  ? 191 GLN A CG  1 
ATOM   149  C CD  . GLN A 1 210 ? -5.166  55.606  108.464 1.00 96.29  ? 191 GLN A CD  1 
ATOM   150  O OE1 . GLN A 1 210 ? -5.330  55.425  107.250 1.00 103.95 ? 191 GLN A OE1 1 
ATOM   151  N NE2 . GLN A 1 210 ? -4.520  56.671  108.955 1.00 95.92  ? 191 GLN A NE2 1 
ATOM   152  N N   . GLU A 1 211 ? -4.519  51.858  111.777 1.00 80.21  ? 192 GLU A N   1 
ATOM   153  C CA  . GLU A 1 211 ? -5.346  51.611  112.944 1.00 71.22  ? 192 GLU A CA  1 
ATOM   154  C C   . GLU A 1 211 ? -4.494  51.427  114.180 1.00 71.17  ? 192 GLU A C   1 
ATOM   155  O O   . GLU A 1 211 ? -4.828  51.938  115.253 1.00 74.73  ? 192 GLU A O   1 
ATOM   156  C CB  . GLU A 1 211 ? -6.233  50.408  112.671 1.00 68.32  ? 192 GLU A CB  1 
ATOM   157  C CG  . GLU A 1 211 ? -6.972  50.602  111.368 1.00 81.14  ? 192 GLU A CG  1 
ATOM   158  C CD  . GLU A 1 211 ? -7.836  49.426  110.878 1.00 86.51  ? 192 GLU A CD  1 
ATOM   159  O OE1 . GLU A 1 211 ? -7.392  48.236  110.861 1.00 76.73  ? 192 GLU A OE1 1 
ATOM   160  O OE2 . GLU A 1 211 ? -8.972  49.738  110.457 1.00 83.84  ? 192 GLU A OE2 1 
ATOM   161  N N   . ALA A 1 212 ? -3.369  50.744  114.036 1.00 68.21  ? 193 ALA A N   1 
ATOM   162  C CA  . ALA A 1 212 ? -2.380  50.734  115.099 1.00 71.45  ? 193 ALA A CA  1 
ATOM   163  C C   . ALA A 1 212 ? -2.080  52.148  115.592 1.00 77.07  ? 193 ALA A C   1 
ATOM   164  O O   . ALA A 1 212 ? -1.863  52.374  116.788 1.00 74.55  ? 193 ALA A O   1 
ATOM   165  C CB  . ALA A 1 212 ? -1.109  50.057  114.598 1.00 70.71  ? 193 ALA A CB  1 
ATOM   166  N N   . ALA A 1 213 ? -2.064  53.118  114.682 1.00 79.74  ? 194 ALA A N   1 
ATOM   167  C CA  . ALA A 1 213 ? -1.751  54.477  115.094 1.00 78.28  ? 194 ALA A CA  1 
ATOM   168  C C   . ALA A 1 213 ? -2.845  55.041  115.986 1.00 79.37  ? 194 ALA A C   1 
ATOM   169  O O   . ALA A 1 213 ? -2.562  55.592  117.056 1.00 82.06  ? 194 ALA A O   1 
ATOM   170  C CB  . ALA A 1 213 ? -1.539  55.349  113.870 1.00 78.90  ? 194 ALA A CB  1 
ATOM   171  N N   . CYS A 1 214 ? -4.105  54.880  115.584 1.00 74.95  ? 195 CYS A N   1 
ATOM   172  C CA  . CYS A 1 214 ? -5.196  55.420  116.382 1.00 80.56  ? 195 CYS A CA  1 
ATOM   173  C C   . CYS A 1 214 ? -5.564  54.532  117.563 1.00 79.91  ? 195 CYS A C   1 
ATOM   174  O O   . CYS A 1 214 ? -6.059  55.034  118.575 1.00 89.68  ? 195 CYS A O   1 
ATOM   175  C CB  . CYS A 1 214 ? -6.411  55.632  115.508 1.00 80.41  ? 195 CYS A CB  1 
ATOM   176  S SG  . CYS A 1 214 ? -5.892  56.267  113.955 1.00 98.83  ? 195 CYS A SG  1 
ATOM   177  N N   . PHE A 1 215 ? -5.316  53.238  117.444 1.00 75.90  ? 196 PHE A N   1 
ATOM   178  C CA  . PHE A 1 215 ? -5.712  52.321  118.530 1.00 72.31  ? 196 PHE A CA  1 
ATOM   179  C C   . PHE A 1 215 ? -4.533  51.481  118.973 1.00 70.98  ? 196 PHE A C   1 
ATOM   180  O O   . PHE A 1 215 ? -4.567  50.298  118.856 1.00 66.14  ? 196 PHE A O   1 
ATOM   181  C CB  . PHE A 1 215 ? -6.810  51.388  118.038 1.00 66.42  ? 196 PHE A CB  1 
ATOM   182  C CG  . PHE A 1 215 ? -7.973  52.074  117.393 1.00 73.62  ? 196 PHE A CG  1 
ATOM   183  C CD1 . PHE A 1 215 ? -7.891  52.543  116.109 1.00 76.87  ? 196 PHE A CD1 1 
ATOM   184  C CD2 . PHE A 1 215 ? -9.158  52.226  118.064 1.00 79.19  ? 196 PHE A CD2 1 
ATOM   185  C CE1 . PHE A 1 215 ? -8.966  53.167  115.516 1.00 79.52  ? 196 PHE A CE1 1 
ATOM   186  C CE2 . PHE A 1 215 ? -10.233 52.850  117.471 1.00 79.33  ? 196 PHE A CE2 1 
ATOM   187  C CZ  . PHE A 1 215 ? -10.135 53.316  116.196 1.00 79.79  ? 196 PHE A CZ  1 
ATOM   188  N N   . PRO A 1 216 ? -3.501  52.045  119.597 1.00 72.63  ? 197 PRO A N   1 
ATOM   189  C CA  . PRO A 1 216 ? -2.390  51.255  120.046 1.00 71.97  ? 197 PRO A CA  1 
ATOM   190  C C   . PRO A 1 216 ? -2.728  50.434  121.288 1.00 78.01  ? 197 PRO A C   1 
ATOM   191  O O   . PRO A 1 216 ? -2.013  49.549  121.584 1.00 81.96  ? 197 PRO A O   1 
ATOM   192  C CB  . PRO A 1 216 ? -1.359  52.306  120.406 1.00 71.65  ? 197 PRO A CB  1 
ATOM   193  C CG  . PRO A 1 216 ? -2.192  53.440  120.840 1.00 79.23  ? 197 PRO A CG  1 
ATOM   194  C CD  . PRO A 1 216 ? -3.339  53.438  119.869 1.00 74.97  ? 197 PRO A CD  1 
ATOM   195  N N   . ASP A 1 217 ? -3.777  50.784  122.014 1.00 85.28  ? 198 ASP A N   1 
ATOM   196  C CA  . ASP A 1 217 ? -4.158  49.951  123.169 1.00 83.21  ? 198 ASP A CA  1 
ATOM   197  C C   . ASP A 1 217 ? -4.586  48.613  122.592 1.00 83.97  ? 198 ASP A C   1 
ATOM   198  O O   . ASP A 1 217 ? -4.102  47.597  123.036 1.00 88.83  ? 198 ASP A O   1 
ATOM   199  C CB  . ASP A 1 217 ? -5.352  50.555  123.892 1.00 74.87  ? 198 ASP A CB  1 
ATOM   200  C CG  . ASP A 1 217 ? -6.124  51.472  122.986 1.00 78.90  ? 198 ASP A CG  1 
ATOM   201  O OD1 . ASP A 1 217 ? -5.557  51.853  122.004 1.00 81.03  ? 198 ASP A OD1 1 
ATOM   202  O OD2 . ASP A 1 217 ? -7.274  51.742  123.250 1.00 89.42  ? 198 ASP A OD2 1 
ATOM   203  N N   . ILE A 1 218 ? -5.423  48.653  121.571 1.00 78.00  ? 199 ILE A N   1 
ATOM   204  C CA  . ILE A 1 218 ? -5.983  47.408  121.002 1.00 79.02  ? 199 ILE A CA  1 
ATOM   205  C C   . ILE A 1 218 ? -4.874  46.550  120.413 1.00 84.96  ? 199 ILE A C   1 
ATOM   206  O O   . ILE A 1 218 ? -4.757  45.424  120.807 1.00 93.81  ? 199 ILE A O   1 
ATOM   207  C CB  . ILE A 1 218 ? -7.010  47.733  119.919 1.00 75.06  ? 199 ILE A CB  1 
ATOM   208  C CG1 . ILE A 1 218 ? -8.248  48.429  120.464 1.00 71.41  ? 199 ILE A CG1 1 
ATOM   209  C CG2 . ILE A 1 218 ? -7.379  46.467  119.197 1.00 75.30  ? 199 ILE A CG2 1 
ATOM   210  C CD1 . ILE A 1 218 ? -8.113  48.876  121.866 1.00 77.67  ? 199 ILE A CD1 1 
ATOM   211  N N   . ILE A 1 219 ? -4.044  47.104  119.550 1.00 83.26  ? 200 ILE A N   1 
ATOM   212  C CA  . ILE A 1 219 ? -3.118  46.236  118.833 1.00 80.44  ? 200 ILE A CA  1 
ATOM   213  C C   . ILE A 1 219 ? -2.086  45.649  119.783 1.00 79.72  ? 200 ILE A C   1 
ATOM   214  O O   . ILE A 1 219 ? -1.690  44.492  119.633 1.00 88.40  ? 200 ILE A O   1 
ATOM   215  C CB  . ILE A 1 219 ? -2.469  46.981  117.644 1.00 80.75  ? 200 ILE A CB  1 
ATOM   216  C CG1 . ILE A 1 219 ? -1.839  45.987  116.689 1.00 78.59  ? 200 ILE A CG1 1 
ATOM   217  C CG2 . ILE A 1 219 ? -1.435  47.997  118.071 1.00 81.90  ? 200 ILE A CG2 1 
ATOM   218  C CD1 . ILE A 1 219 ? -1.552  46.564  115.365 1.00 71.60  ? 200 ILE A CD1 1 
ATOM   219  N N   . SER A 1 220 ? -1.652  46.408  120.782 1.00 75.91  ? 201 SER A N   1 
ATOM   220  C CA  . SER A 1 220 ? -0.694  45.860  121.732 1.00 82.78  ? 201 SER A CA  1 
ATOM   221  C C   . SER A 1 220 ? -1.364  44.981  122.775 1.00 89.66  ? 201 SER A C   1 
ATOM   222  O O   . SER A 1 220 ? -0.662  44.365  123.595 1.00 93.06  ? 201 SER A O   1 
ATOM   223  C CB  . SER A 1 220 ? 0.095   46.992  122.411 1.00 84.99  ? 201 SER A CB  1 
ATOM   224  O OG  . SER A 1 220 ? -0.639  47.617  123.450 1.00 91.37  ? 201 SER A OG  1 
ATOM   225  N N   . GLY A 1 221 ? -2.696  44.895  122.729 1.00 87.49  ? 202 GLY A N   1 
ATOM   226  C CA  . GLY A 1 221 ? -3.479  44.196  123.709 1.00 91.30  ? 202 GLY A CA  1 
ATOM   227  C C   . GLY A 1 221 ? -3.876  42.804  123.275 1.00 96.78  ? 202 GLY A C   1 
ATOM   228  O O   . GLY A 1 221 ? -3.412  42.279  122.255 1.00 95.33  ? 202 GLY A O   1 
ATOM   229  N N   . PRO A 1 222 ? -4.749  42.179  124.066 1.00 104.54 ? 203 PRO A N   1 
ATOM   230  C CA  . PRO A 1 222 ? -5.107  40.769  123.836 1.00 103.54 ? 203 PRO A CA  1 
ATOM   231  C C   . PRO A 1 222 ? -5.837  40.517  122.515 1.00 101.65 ? 203 PRO A C   1 
ATOM   232  O O   . PRO A 1 222 ? -6.748  41.258  122.125 1.00 96.48  ? 203 PRO A O   1 
ATOM   233  C CB  . PRO A 1 222 ? -6.005  40.448  125.038 1.00 104.71 ? 203 PRO A CB  1 
ATOM   234  C CG  . PRO A 1 222 ? -6.478  41.829  125.557 1.00 93.66  ? 203 PRO A CG  1 
ATOM   235  C CD  . PRO A 1 222 ? -5.290  42.689  125.341 1.00 94.18  ? 203 PRO A CD  1 
ATOM   236  N N   . GLN A 1 223 ? -5.453  39.412  121.853 1.00 100.12 ? 204 GLN A N   1 
ATOM   237  C CA  . GLN A 1 223 ? -5.983  39.079  120.531 1.00 97.96  ? 204 GLN A CA  1 
ATOM   238  C C   . GLN A 1 223 ? -7.504  39.011  120.503 1.00 98.39  ? 204 GLN A C   1 
ATOM   239  O O   . GLN A 1 223 ? -8.097  39.104  119.424 1.00 96.29  ? 204 GLN A O   1 
ATOM   240  C CB  . GLN A 1 223 ? -5.397  37.754  120.033 1.00 94.12  ? 204 GLN A CB  1 
ATOM   241  C CG  . GLN A 1 223 ? -3.954  37.870  119.543 1.00 100.71 ? 204 GLN A CG  1 
ATOM   242  C CD  . GLN A 1 223 ? -3.854  38.063  118.021 1.00 111.97 ? 204 GLN A CD  1 
ATOM   243  O OE1 . GLN A 1 223 ? -4.869  38.089  117.306 1.00 106.88 ? 204 GLN A OE1 1 
ATOM   244  N NE2 . GLN A 1 223 ? -2.626  38.222  117.527 1.00 114.33 ? 204 GLN A NE2 1 
ATOM   245  N N   . GLN A 1 224 ? -8.153  38.858  121.654 1.00 104.85 ? 205 GLN A N   1 
ATOM   246  C CA  . GLN A 1 224 ? -9.609  38.826  121.652 1.00 108.20 ? 205 GLN A CA  1 
ATOM   247  C C   . GLN A 1 224 ? -10.174 40.199  121.342 1.00 102.08 ? 205 GLN A C   1 
ATOM   248  O O   . GLN A 1 224 ? -11.044 40.333  120.470 1.00 101.43 ? 205 GLN A O   1 
ATOM   249  C CB  . GLN A 1 224 ? -10.152 38.287  122.984 1.00 115.73 ? 205 GLN A CB  1 
ATOM   250  C CG  . GLN A 1 224 ? -11.692 38.123  123.027 1.00 116.74 ? 205 GLN A CG  1 
ATOM   251  C CD  . GLN A 1 224 ? -12.267 37.233  121.905 1.00 127.34 ? 205 GLN A CD  1 
ATOM   252  O OE1 . GLN A 1 224 ? -11.542 36.502  121.206 1.00 123.24 ? 205 GLN A OE1 1 
ATOM   253  N NE2 . GLN A 1 224 ? -13.586 37.324  121.714 1.00 126.95 ? 205 GLN A NE2 1 
ATOM   254  N N   . THR A 1 225 ? -9.673  41.238  122.027 1.00 99.18  ? 206 THR A N   1 
ATOM   255  C CA  . THR A 1 225 ? -10.175 42.588  121.771 1.00 106.27 ? 206 THR A CA  1 
ATOM   256  C C   . THR A 1 225 ? -9.944  42.986  120.316 1.00 100.04 ? 206 THR A C   1 
ATOM   257  O O   . THR A 1 225 ? -10.826 43.579  119.685 1.00 94.83  ? 206 THR A O   1 
ATOM   258  C CB  . THR A 1 225 ? -9.531  43.613  122.718 1.00 108.34 ? 206 THR A CB  1 
ATOM   259  O OG1 . THR A 1 225 ? -8.099  43.508  122.655 1.00 110.82 ? 206 THR A OG1 1 
ATOM   260  C CG2 . THR A 1 225 ? -10.004 43.390  124.173 1.00 100.41 ? 206 THR A CG2 1 
ATOM   261  N N   . GLN A 1 226 ? -8.771  42.642  119.760 1.00 95.91  ? 207 GLN A N   1 
ATOM   262  C CA  . GLN A 1 226 ? -8.511  42.891  118.344 1.00 91.26  ? 207 GLN A CA  1 
ATOM   263  C C   . GLN A 1 226 ? -9.647  42.360  117.476 1.00 94.44  ? 207 GLN A C   1 
ATOM   264  O O   . GLN A 1 226 ? -10.176 43.079  116.617 1.00 91.98  ? 207 GLN A O   1 
ATOM   265  C CB  . GLN A 1 226 ? -7.181  42.260  117.924 1.00 86.68  ? 207 GLN A CB  1 
ATOM   266  C CG  . GLN A 1 226 ? -5.974  42.696  118.735 1.00 86.47  ? 207 GLN A CG  1 
ATOM   267  C CD  . GLN A 1 226 ? -4.672  42.214  118.120 1.00 90.02  ? 207 GLN A CD  1 
ATOM   268  O OE1 . GLN A 1 226 ? -4.649  41.792  116.965 1.00 96.28  ? 207 GLN A OE1 1 
ATOM   269  N NE2 . GLN A 1 226 ? -3.586  42.254  118.890 1.00 84.27  ? 207 GLN A NE2 1 
ATOM   270  N N   . LYS A 1 227 ? -10.053 41.102  117.709 1.00 94.97  ? 208 LYS A N   1 
ATOM   271  C CA  . LYS A 1 227 ? -11.097 40.486  116.890 1.00 96.02  ? 208 LYS A CA  1 
ATOM   272  C C   . LYS A 1 227 ? -12.423 41.222  117.044 1.00 95.42  ? 208 LYS A C   1 
ATOM   273  O O   . LYS A 1 227 ? -13.191 41.357  116.078 1.00 88.41  ? 208 LYS A O   1 
ATOM   274  C CB  . LYS A 1 227 ? -11.256 39.011  117.263 1.00 99.34  ? 208 LYS A CB  1 
ATOM   275  C CG  . LYS A 1 227 ? -10.053 38.134  116.913 1.00 109.53 ? 208 LYS A CG  1 
ATOM   276  C CD  . LYS A 1 227 ? -10.397 36.629  116.929 1.00 114.92 ? 208 LYS A CD  1 
ATOM   277  C CE  . LYS A 1 227 ? -9.133  35.745  116.991 1.00 113.06 ? 208 LYS A CE  1 
ATOM   278  N NZ  . LYS A 1 227 ? -9.253  34.486  116.176 1.00 111.89 ? 208 LYS A NZ  1 
ATOM   279  N N   . VAL A 1 228 ? -12.712 41.688  118.257 1.00 93.97  ? 209 VAL A N   1 
ATOM   280  C CA  . VAL A 1 228 ? -13.859 42.545  118.518 1.00 97.48  ? 209 VAL A CA  1 
ATOM   281  C C   . VAL A 1 228 ? -13.739 43.774  117.626 1.00 96.87  ? 209 VAL A C   1 
ATOM   282  O O   . VAL A 1 228 ? -14.543 43.979  116.707 1.00 94.60  ? 209 VAL A O   1 
ATOM   283  C CB  . VAL A 1 228 ? -13.921 42.943  120.006 1.00 99.45  ? 209 VAL A CB  1 
ATOM   284  C CG1 . VAL A 1 228 ? -15.212 43.697  120.323 1.00 95.43  ? 209 VAL A CG1 1 
ATOM   285  C CG2 . VAL A 1 228 ? -13.763 41.720  120.881 1.00 98.02  ? 209 VAL A CG2 1 
ATOM   286  N N   . PHE A 1 229 ? -12.719 44.589  117.901 1.00 92.89  ? 210 PHE A N   1 
ATOM   287  C CA  . PHE A 1 229 ? -12.402 45.753  117.090 1.00 89.65  ? 210 PHE A CA  1 
ATOM   288  C C   . PHE A 1 229 ? -12.621 45.479  115.613 1.00 90.56  ? 210 PHE A C   1 
ATOM   289  O O   . PHE A 1 229 ? -13.375 46.188  114.932 1.00 87.28  ? 210 PHE A O   1 
ATOM   290  C CB  . PHE A 1 229 ? -10.944 46.163  117.308 1.00 84.67  ? 210 PHE A CB  1 
ATOM   291  C CG  . PHE A 1 229 ? -10.492 47.219  116.367 1.00 87.35  ? 210 PHE A CG  1 
ATOM   292  C CD1 . PHE A 1 229 ? -10.575 48.545  116.713 1.00 88.49  ? 210 PHE A CD1 1 
ATOM   293  C CD2 . PHE A 1 229 ? -10.047 46.896  115.098 1.00 93.49  ? 210 PHE A CD2 1 
ATOM   294  C CE1 . PHE A 1 229 ? -10.180 49.524  115.828 1.00 89.64  ? 210 PHE A CE1 1 
ATOM   295  C CE2 . PHE A 1 229 ? -9.670  47.867  114.206 1.00 87.77  ? 210 PHE A CE2 1 
ATOM   296  C CZ  . PHE A 1 229 ? -9.730  49.178  114.572 1.00 87.52  ? 210 PHE A CZ  1 
ATOM   297  N N   . LEU A 1 230 ? -11.918 44.456  115.111 1.00 86.37  ? 211 LEU A N   1 
ATOM   298  C CA  . LEU A 1 230 ? -11.946 44.163  113.686 1.00 88.50  ? 211 LEU A CA  1 
ATOM   299  C C   . LEU A 1 230 ? -13.372 43.961  113.215 1.00 90.33  ? 211 LEU A C   1 
ATOM   300  O O   . LEU A 1 230 ? -13.790 44.534  112.201 1.00 87.70  ? 211 LEU A O   1 
ATOM   301  C CB  . LEU A 1 230 ? -11.076 42.945  113.389 1.00 85.07  ? 211 LEU A CB  1 
ATOM   302  C CG  . LEU A 1 230 ? -9.586  43.254  113.478 1.00 83.91  ? 211 LEU A CG  1 
ATOM   303  C CD1 . LEU A 1 230 ? -8.741  42.042  113.616 1.00 84.82  ? 211 LEU A CD1 1 
ATOM   304  C CD2 . LEU A 1 230 ? -9.206  43.905  112.214 1.00 86.02  ? 211 LEU A CD2 1 
ATOM   305  N N   . PHE A 1 231 ? -14.153 43.191  113.976 1.00 92.18  ? 212 PHE A N   1 
ATOM   306  C CA  . PHE A 1 231 ? -15.557 43.019  113.629 1.00 94.59  ? 212 PHE A CA  1 
ATOM   307  C C   . PHE A 1 231 ? -16.288 44.359  113.649 1.00 95.77  ? 212 PHE A C   1 
ATOM   308  O O   . PHE A 1 231 ? -17.044 44.684  112.720 1.00 92.62  ? 212 PHE A O   1 
ATOM   309  C CB  . PHE A 1 231 ? -16.230 42.013  114.571 1.00 95.92  ? 212 PHE A CB  1 
ATOM   310  C CG  . PHE A 1 231 ? -17.683 41.805  114.255 1.00 103.34 ? 212 PHE A CG  1 
ATOM   311  C CD1 . PHE A 1 231 ? -18.651 42.621  114.808 1.00 110.12 ? 212 PHE A CD1 1 
ATOM   312  C CD2 . PHE A 1 231 ? -18.072 40.859  113.333 1.00 111.13 ? 212 PHE A CD2 1 
ATOM   313  C CE1 . PHE A 1 231 ? -19.981 42.464  114.486 1.00 113.58 ? 212 PHE A CE1 1 
ATOM   314  C CE2 . PHE A 1 231 ? -19.405 40.698  113.003 1.00 115.24 ? 212 PHE A CE2 1 
ATOM   315  C CZ  . PHE A 1 231 ? -20.359 41.501  113.581 1.00 115.52 ? 212 PHE A CZ  1 
ATOM   316  N N   . ILE A 1 232 ? -16.082 45.147  114.711 1.00 91.03  ? 213 ILE A N   1 
ATOM   317  C CA  . ILE A 1 232 ? -16.739 46.445  114.803 1.00 87.45  ? 213 ILE A CA  1 
ATOM   318  C C   . ILE A 1 232 ? -16.399 47.291  113.596 1.00 85.67  ? 213 ILE A C   1 
ATOM   319  O O   . ILE A 1 232 ? -17.284 47.881  112.965 1.00 83.34  ? 213 ILE A O   1 
ATOM   320  C CB  . ILE A 1 232 ? -16.362 47.147  116.113 1.00 89.72  ? 213 ILE A CB  1 
ATOM   321  C CG1 . ILE A 1 232 ? -16.526 46.163  117.264 1.00 89.82  ? 213 ILE A CG1 1 
ATOM   322  C CG2 . ILE A 1 232 ? -17.181 48.401  116.291 1.00 86.40  ? 213 ILE A CG2 1 
ATOM   323  C CD1 . ILE A 1 232 ? -15.889 46.601  118.508 1.00 87.96  ? 213 ILE A CD1 1 
ATOM   324  N N   . ARG A 1 233 ? -15.115 47.334  113.233 1.00 89.54  ? 214 ARG A N   1 
ATOM   325  C CA  . ARG A 1 233 ? -14.736 48.026  112.008 1.00 87.48  ? 214 ARG A CA  1 
ATOM   326  C C   . ARG A 1 233 ? -15.445 47.421  110.812 1.00 88.29  ? 214 ARG A C   1 
ATOM   327  O O   . ARG A 1 233 ? -16.151 48.122  110.073 1.00 88.39  ? 214 ARG A O   1 
ATOM   328  C CB  . ARG A 1 233 ? -13.227 47.982  111.774 1.00 86.52  ? 214 ARG A CB  1 
ATOM   329  C CG  . ARG A 1 233 ? -12.984 48.204  110.290 1.00 85.28  ? 214 ARG A CG  1 
ATOM   330  C CD  . ARG A 1 233 ? -11.592 48.500  109.799 1.00 86.05  ? 214 ARG A CD  1 
ATOM   331  N NE  . ARG A 1 233 ? -10.545 47.509  110.048 1.00 79.74  ? 214 ARG A NE  1 
ATOM   332  C CZ  . ARG A 1 233 ? -10.401 46.388  109.355 1.00 78.50  ? 214 ARG A CZ  1 
ATOM   333  N NH1 . ARG A 1 233 ? -11.271 46.075  108.416 1.00 85.55  ? 214 ARG A NH1 1 
ATOM   334  N NH2 . ARG A 1 233 ? -9.395  45.575  109.603 1.00 78.84  ? 214 ARG A NH2 1 
ATOM   335  N N   . ASN A 1 234 ? -15.247 46.107  110.603 1.00 89.57  ? 215 ASN A N   1 
ATOM   336  C CA  . ASN A 1 234 ? -15.754 45.444  109.404 1.00 85.74  ? 215 ASN A CA  1 
ATOM   337  C C   . ASN A 1 234 ? -17.253 45.615  109.296 1.00 88.17  ? 215 ASN A C   1 
ATOM   338  O O   . ASN A 1 234 ? -17.780 45.914  108.218 1.00 82.25  ? 215 ASN A O   1 
ATOM   339  C CB  . ASN A 1 234 ? -15.399 43.961  109.426 1.00 85.38  ? 215 ASN A CB  1 
ATOM   340  C CG  . ASN A 1 234 ? -13.913 43.717  109.325 1.00 90.66  ? 215 ASN A CG  1 
ATOM   341  O OD1 . ASN A 1 234 ? -13.154 44.610  108.941 1.00 90.78  ? 215 ASN A OD1 1 
ATOM   342  N ND2 . ASN A 1 234 ? -13.482 42.508  109.673 1.00 91.82  ? 215 ASN A ND2 1 
ATOM   343  N N   . ARG A 1 235 ? -17.952 45.443  110.419 1.00 91.06  ? 216 ARG A N   1 
ATOM   344  C CA  . ARG A 1 235 ? -19.379 45.716  110.475 1.00 90.13  ? 216 ARG A CA  1 
ATOM   345  C C   . ARG A 1 235 ? -19.665 47.130  109.998 1.00 88.65  ? 216 ARG A C   1 
ATOM   346  O O   . ARG A 1 235 ? -20.318 47.339  108.971 1.00 89.39  ? 216 ARG A O   1 
ATOM   347  C CB  . ARG A 1 235 ? -19.884 45.501  111.902 1.00 89.37  ? 216 ARG A CB  1 
ATOM   348  C CG  . ARG A 1 235 ? -21.394 45.393  112.029 1.00 98.45  ? 216 ARG A CG  1 
ATOM   349  C CD  . ARG A 1 235 ? -22.043 44.339  111.135 1.00 99.27  ? 216 ARG A CD  1 
ATOM   350  N NE  . ARG A 1 235 ? -23.503 44.435  111.208 1.00 102.04 ? 216 ARG A NE  1 
ATOM   351  C CZ  . ARG A 1 235 ? -24.305 44.570  110.151 1.00 109.82 ? 216 ARG A CZ  1 
ATOM   352  N NH1 . ARG A 1 235 ? -23.798 44.611  108.927 1.00 104.79 ? 216 ARG A NH1 1 
ATOM   353  N NH2 . ARG A 1 235 ? -25.619 44.658  110.308 1.00 113.28 ? 216 ARG A NH2 1 
ATOM   354  N N   . THR A 1 236 ? -19.112 48.111  110.702 1.00 87.74  ? 217 THR A N   1 
ATOM   355  C CA  . THR A 1 236 ? -19.452 49.499  110.430 1.00 86.34  ? 217 THR A CA  1 
ATOM   356  C C   . THR A 1 236 ? -19.253 49.841  108.960 1.00 88.75  ? 217 THR A C   1 
ATOM   357  O O   . THR A 1 236 ? -20.095 50.503  108.338 1.00 85.80  ? 217 THR A O   1 
ATOM   358  C CB  . THR A 1 236 ? -18.590 50.388  111.303 1.00 84.32  ? 217 THR A CB  1 
ATOM   359  O OG1 . THR A 1 236 ? -18.690 49.918  112.653 1.00 85.87  ? 217 THR A OG1 1 
ATOM   360  C CG2 . THR A 1 236 ? -19.133 51.784  111.261 1.00 85.87  ? 217 THR A CG2 1 
ATOM   361  N N   . LEU A 1 237 ? -18.142 49.371  108.390 1.00 90.70  ? 218 LEU A N   1 
ATOM   362  C CA  . LEU A 1 237 ? -17.915 49.475  106.954 1.00 86.26  ? 218 LEU A CA  1 
ATOM   363  C C   . LEU A 1 237 ? -19.093 48.930  106.159 1.00 91.87  ? 218 LEU A C   1 
ATOM   364  O O   . LEU A 1 237 ? -19.624 49.613  105.273 1.00 91.06  ? 218 LEU A O   1 
ATOM   365  C CB  . LEU A 1 237 ? -16.649 48.721  106.590 1.00 80.79  ? 218 LEU A CB  1 
ATOM   366  C CG  . LEU A 1 237 ? -15.398 49.379  107.114 1.00 82.43  ? 218 LEU A CG  1 
ATOM   367  C CD1 . LEU A 1 237 ? -14.295 48.355  107.208 1.00 80.36  ? 218 LEU A CD1 1 
ATOM   368  C CD2 . LEU A 1 237 ? -15.039 50.520  106.161 1.00 85.06  ? 218 LEU A CD2 1 
ATOM   369  N N   . GLN A 1 238 ? -19.485 47.679  106.443 1.00 90.79  ? 219 GLN A N   1 
ATOM   370  C CA  . GLN A 1 238 ? -20.662 47.081  105.817 1.00 88.12  ? 219 GLN A CA  1 
ATOM   371  C C   . GLN A 1 238 ? -21.816 48.063  105.842 1.00 95.40  ? 219 GLN A C   1 
ATOM   372  O O   . GLN A 1 238 ? -22.266 48.541  104.790 1.00 95.84  ? 219 GLN A O   1 
ATOM   373  C CB  . GLN A 1 238 ? -21.028 45.776  106.536 1.00 92.32  ? 219 GLN A CB  1 
ATOM   374  C CG  . GLN A 1 238 ? -22.051 44.856  105.838 1.00 104.43 ? 219 GLN A CG  1 
ATOM   375  C CD  . GLN A 1 238 ? -22.197 43.471  106.523 1.00 110.46 ? 219 GLN A CD  1 
ATOM   376  O OE1 . GLN A 1 238 ? -21.793 43.283  107.679 1.00 105.17 ? 219 GLN A OE1 1 
ATOM   377  N NE2 . GLN A 1 238 ? -22.772 42.504  105.799 1.00 111.45 ? 219 GLN A NE2 1 
ATOM   378  N N   . LEU A 1 239 ? -22.230 48.446  107.053 1.00 93.09  ? 220 LEU A N   1 
ATOM   379  C CA  . LEU A 1 239 ? -23.381 49.324  107.229 1.00 91.73  ? 220 LEU A CA  1 
ATOM   380  C C   . LEU A 1 239 ? -23.349 50.493  106.248 1.00 97.80  ? 220 LEU A C   1 
ATOM   381  O O   . LEU A 1 239 ? -24.298 50.700  105.475 1.00 99.67  ? 220 LEU A O   1 
ATOM   382  C CB  . LEU A 1 239 ? -23.412 49.831  108.664 1.00 92.55  ? 220 LEU A CB  1 
ATOM   383  C CG  . LEU A 1 239 ? -23.895 48.919  109.791 1.00 94.42  ? 220 LEU A CG  1 
ATOM   384  C CD1 . LEU A 1 239 ? -25.333 48.464  109.586 1.00 101.22 ? 220 LEU A CD1 1 
ATOM   385  C CD2 . LEU A 1 239 ? -22.972 47.755  110.012 1.00 91.28  ? 220 LEU A CD2 1 
ATOM   386  N N   . TRP A 1 240 ? -22.236 51.239  106.236 1.00 91.93  ? 221 TRP A N   1 
ATOM   387  C CA  . TRP A 1 240 ? -22.072 52.324  105.272 1.00 92.00  ? 221 TRP A CA  1 
ATOM   388  C C   . TRP A 1 240 ? -22.260 51.832  103.840 1.00 96.01  ? 221 TRP A C   1 
ATOM   389  O O   . TRP A 1 240 ? -22.941 52.480  103.031 1.00 97.05  ? 221 TRP A O   1 
ATOM   390  C CB  . TRP A 1 240 ? -20.690 52.980  105.429 1.00 89.32  ? 221 TRP A CB  1 
ATOM   391  C CG  . TRP A 1 240 ? -20.255 53.822  104.216 1.00 90.46  ? 221 TRP A CG  1 
ATOM   392  C CD1 . TRP A 1 240 ? -19.172 53.608  103.409 1.00 87.85  ? 221 TRP A CD1 1 
ATOM   393  C CD2 . TRP A 1 240 ? -20.914 54.984  103.686 1.00 88.92  ? 221 TRP A CD2 1 
ATOM   394  N NE1 . TRP A 1 240 ? -19.120 54.554  102.418 1.00 81.68  ? 221 TRP A NE1 1 
ATOM   395  C CE2 . TRP A 1 240 ? -20.180 55.408  102.565 1.00 82.85  ? 221 TRP A CE2 1 
ATOM   396  C CE3 . TRP A 1 240 ? -22.049 55.704  104.054 1.00 92.03  ? 221 TRP A CE3 1 
ATOM   397  C CZ2 . TRP A 1 240 ? -20.538 56.513  101.821 1.00 85.91  ? 221 TRP A CZ2 1 
ATOM   398  C CZ3 . TRP A 1 240 ? -22.403 56.800  103.311 1.00 93.05  ? 221 TRP A CZ3 1 
ATOM   399  C CH2 . TRP A 1 240 ? -21.652 57.194  102.207 1.00 91.24  ? 221 TRP A CH2 1 
ATOM   400  N N   . LEU A 1 241 ? -21.690 50.670  103.520 1.00 91.31  ? 222 LEU A N   1 
ATOM   401  C CA  . LEU A 1 241 ? -21.581 50.261  102.125 1.00 94.15  ? 222 LEU A CA  1 
ATOM   402  C C   . LEU A 1 241 ? -22.930 49.831  101.553 1.00 103.75 ? 222 LEU A C   1 
ATOM   403  O O   . LEU A 1 241 ? -23.244 50.136  100.391 1.00 98.99  ? 222 LEU A O   1 
ATOM   404  C CB  . LEU A 1 241 ? -20.540 49.151  102.019 1.00 90.24  ? 222 LEU A CB  1 
ATOM   405  C CG  . LEU A 1 241 ? -19.121 49.725  101.961 1.00 87.36  ? 222 LEU A CG  1 
ATOM   406  C CD1 . LEU A 1 241 ? -18.020 48.658  102.028 1.00 82.85  ? 222 LEU A CD1 1 
ATOM   407  C CD2 . LEU A 1 241 ? -18.984 50.566  100.704 1.00 81.03  ? 222 LEU A CD2 1 
ATOM   408  N N   . ASP A 1 242 ? -23.751 49.145  102.363 1.00 107.14 ? 223 ASP A N   1 
ATOM   409  C CA  . ASP A 1 242 ? -25.025 48.625  101.870 1.00 108.64 ? 223 ASP A CA  1 
ATOM   410  C C   . ASP A 1 242 ? -25.997 49.743  101.531 1.00 110.97 ? 223 ASP A C   1 
ATOM   411  O O   . ASP A 1 242 ? -26.829 49.585  100.629 1.00 116.12 ? 223 ASP A O   1 
ATOM   412  C CB  . ASP A 1 242 ? -25.648 47.678  102.891 1.00 112.75 ? 223 ASP A CB  1 
ATOM   413  C CG  . ASP A 1 242 ? -24.738 46.492  103.228 1.00 122.31 ? 223 ASP A CG  1 
ATOM   414  O OD1 . ASP A 1 242 ? -25.060 45.336  102.858 1.00 122.99 ? 223 ASP A OD1 1 
ATOM   415  O OD2 . ASP A 1 242 ? -23.687 46.710  103.864 1.00 117.85 ? 223 ASP A OD2 1 
ATOM   416  N N   . ASN A 1 243 ? -25.912 50.871  102.232 1.00 109.20 ? 224 ASN A N   1 
ATOM   417  C CA  . ASN A 1 243 ? -26.611 52.088  101.831 1.00 110.96 ? 224 ASN A CA  1 
ATOM   418  C C   . ASN A 1 243 ? -25.654 53.271  101.920 1.00 108.16 ? 224 ASN A C   1 
ATOM   419  O O   . ASN A 1 243 ? -25.483 53.859  103.003 1.00 108.36 ? 224 ASN A O   1 
ATOM   420  C CB  . ASN A 1 243 ? -27.848 52.337  102.680 1.00 111.00 ? 224 ASN A CB  1 
ATOM   421  C CG  . ASN A 1 243 ? -28.795 53.330  102.026 1.00 122.84 ? 224 ASN A CG  1 
ATOM   422  O OD1 . ASN A 1 243 ? -28.606 53.734  100.856 1.00 113.29 ? 224 ASN A OD1 1 
ATOM   423  N ND2 . ASN A 1 243 ? -29.805 53.759  102.785 1.00 123.82 ? 224 ASN A ND2 1 
ATOM   424  N N   . PRO A 1 244 ? -25.030 53.655  100.829 1.00 104.13 ? 225 PRO A N   1 
ATOM   425  C CA  . PRO A 1 244 ? -24.073 54.761  100.893 1.00 97.52  ? 225 PRO A CA  1 
ATOM   426  C C   . PRO A 1 244 ? -24.698 56.075  100.482 1.00 95.64  ? 225 PRO A C   1 
ATOM   427  O O   . PRO A 1 244 ? -23.979 57.023  100.162 1.00 95.81  ? 225 PRO A O   1 
ATOM   428  C CB  . PRO A 1 244 ? -22.986 54.338  99.901  1.00 98.72  ? 225 PRO A CB  1 
ATOM   429  C CG  . PRO A 1 244 ? -23.657 53.258  99.008  1.00 100.83 ? 225 PRO A CG  1 
ATOM   430  C CD  . PRO A 1 244 ? -25.066 53.050  99.491  1.00 102.55 ? 225 PRO A CD  1 
ATOM   431  N N   . LYS A 1 245 ? -26.024 56.150  100.454 1.00 97.98  ? 226 LYS A N   1 
ATOM   432  C CA  . LYS A 1 245 ? -26.666 57.402  100.075 1.00 102.38 ? 226 LYS A CA  1 
ATOM   433  C C   . LYS A 1 245 ? -27.036 58.269  101.278 1.00 105.72 ? 226 LYS A C   1 
ATOM   434  O O   . LYS A 1 245 ? -27.361 59.450  101.097 1.00 103.93 ? 226 LYS A O   1 
ATOM   435  C CB  . LYS A 1 245 ? -27.919 57.127  99.239  1.00 103.46 ? 226 LYS A CB  1 
ATOM   436  C CG  . LYS A 1 245 ? -27.665 56.405  97.932  1.00 103.97 ? 226 LYS A CG  1 
ATOM   437  C CD  . LYS A 1 245 ? -28.979 56.002  97.267  1.00 107.44 ? 226 LYS A CD  1 
ATOM   438  C CE  . LYS A 1 245 ? -28.951 56.308  95.776  1.00 105.70 ? 226 LYS A CE  1 
ATOM   439  N NZ  . LYS A 1 245 ? -29.259 57.745  95.508  1.00 105.55 ? 226 LYS A NZ  1 
ATOM   440  N N   . ILE A 1 246 ? -26.995 57.720  102.494 1.00 103.08 ? 227 ILE A N   1 
ATOM   441  C CA  . ILE A 1 246 ? -27.318 58.470  103.699 1.00 102.16 ? 227 ILE A CA  1 
ATOM   442  C C   . ILE A 1 246 ? -26.165 58.358  104.682 1.00 100.14 ? 227 ILE A C   1 
ATOM   443  O O   . ILE A 1 246 ? -25.459 57.346  104.728 1.00 97.01  ? 227 ILE A O   1 
ATOM   444  C CB  . ILE A 1 246 ? -28.623 57.986  104.366 1.00 102.79 ? 227 ILE A CB  1 
ATOM   445  C CG1 . ILE A 1 246 ? -28.481 56.538  104.832 1.00 105.36 ? 227 ILE A CG1 1 
ATOM   446  C CG2 . ILE A 1 246 ? -29.799 58.152  103.418 1.00 103.62 ? 227 ILE A CG2 1 
ATOM   447  C CD1 . ILE A 1 246 ? -29.421 56.176  105.960 1.00 108.31 ? 227 ILE A CD1 1 
ATOM   448  N N   . GLN A 1 247 ? -25.991 59.412  105.482 1.00 98.62  ? 228 GLN A N   1 
ATOM   449  C CA  . GLN A 1 247 ? -24.986 59.416  106.532 1.00 93.83  ? 228 GLN A CA  1 
ATOM   450  C C   . GLN A 1 247 ? -25.143 58.200  107.435 1.00 91.61  ? 228 GLN A C   1 
ATOM   451  O O   . GLN A 1 247 ? -26.254 57.735  107.683 1.00 97.19  ? 228 GLN A O   1 
ATOM   452  C CB  . GLN A 1 247 ? -25.091 60.701  107.359 1.00 100.89 ? 228 GLN A CB  1 
ATOM   453  C CG  . GLN A 1 247 ? -24.131 60.732  108.551 1.00 102.10 ? 228 GLN A CG  1 
ATOM   454  C CD  . GLN A 1 247 ? -23.886 62.112  109.112 1.00 99.89  ? 228 GLN A CD  1 
ATOM   455  O OE1 . GLN A 1 247 ? -24.698 63.025  108.955 1.00 105.69 ? 228 GLN A OE1 1 
ATOM   456  N NE2 . GLN A 1 247 ? -22.750 62.271  109.776 1.00 103.81 ? 228 GLN A NE2 1 
ATOM   457  N N   . LEU A 1 248 ? -24.023 57.674  107.909 1.00 86.50  ? 229 LEU A N   1 
ATOM   458  C CA  . LEU A 1 248 ? -24.024 56.617  108.911 1.00 90.08  ? 229 LEU A CA  1 
ATOM   459  C C   . LEU A 1 248 ? -23.579 57.226  110.237 1.00 95.60  ? 229 LEU A C   1 
ATOM   460  O O   . LEU A 1 248 ? -22.390 57.274  110.553 1.00 91.32  ? 229 LEU A O   1 
ATOM   461  C CB  . LEU A 1 248 ? -23.126 55.472  108.518 1.00 90.59  ? 229 LEU A CB  1 
ATOM   462  C CG  . LEU A 1 248 ? -23.167 54.380  109.587 1.00 92.11  ? 229 LEU A CG  1 
ATOM   463  C CD1 . LEU A 1 248 ? -24.309 53.440  109.318 1.00 91.28  ? 229 LEU A CD1 1 
ATOM   464  C CD2 . LEU A 1 248 ? -21.855 53.619  109.680 1.00 89.23  ? 229 LEU A CD2 1 
ATOM   465  N N   . THR A 1 249 ? -24.548 57.679  111.020 1.00 104.41 ? 230 THR A N   1 
ATOM   466  C CA  . THR A 1 249 ? -24.267 58.292  112.307 1.00 98.90  ? 230 THR A CA  1 
ATOM   467  C C   . THR A 1 249 ? -23.809 57.239  113.300 1.00 96.86  ? 230 THR A C   1 
ATOM   468  O O   . THR A 1 249 ? -24.040 56.043  113.127 1.00 98.89  ? 230 THR A O   1 
ATOM   469  C CB  . THR A 1 249 ? -25.512 58.935  112.863 1.00 99.99  ? 230 THR A CB  1 
ATOM   470  O OG1 . THR A 1 249 ? -26.420 57.895  113.226 1.00 101.57 ? 230 THR A OG1 1 
ATOM   471  C CG2 . THR A 1 249 ? -26.140 59.785  111.769 1.00 100.27 ? 230 THR A CG2 1 
ATOM   472  N N   . PHE A 1 250 ? -23.194 57.707  114.382 1.00 95.81  ? 231 PHE A N   1 
ATOM   473  C CA  . PHE A 1 250 ? -22.670 56.778  115.378 1.00 98.13  ? 231 PHE A CA  1 
ATOM   474  C C   . PHE A 1 250 ? -23.792 55.989  116.036 1.00 103.24 ? 231 PHE A C   1 
ATOM   475  O O   . PHE A 1 250 ? -23.656 54.786  116.291 1.00 100.77 ? 231 PHE A O   1 
ATOM   476  C CB  . PHE A 1 250 ? -21.862 57.538  116.422 1.00 93.54  ? 231 PHE A CB  1 
ATOM   477  C CG  . PHE A 1 250 ? -21.564 56.741  117.648 1.00 96.42  ? 231 PHE A CG  1 
ATOM   478  C CD1 . PHE A 1 250 ? -21.034 55.460  117.565 1.00 99.54  ? 231 PHE A CD1 1 
ATOM   479  C CD2 . PHE A 1 250 ? -21.779 57.283  118.895 1.00 97.10  ? 231 PHE A CD2 1 
ATOM   480  C CE1 . PHE A 1 250 ? -20.761 54.727  118.719 1.00 99.83  ? 231 PHE A CE1 1 
ATOM   481  C CE2 . PHE A 1 250 ? -21.491 56.560  120.042 1.00 90.37  ? 231 PHE A CE2 1 
ATOM   482  C CZ  . PHE A 1 250 ? -20.991 55.282  119.955 1.00 91.40  ? 231 PHE A CZ  1 
ATOM   483  N N   . GLU A 1 251 ? -24.912 56.656  116.312 1.00 109.71 ? 232 GLU A N   1 
ATOM   484  C CA  . GLU A 1 251 ? -26.044 56.003  116.956 1.00 110.04 ? 232 GLU A CA  1 
ATOM   485  C C   . GLU A 1 251 ? -26.619 54.917  116.058 1.00 112.27 ? 232 GLU A C   1 
ATOM   486  O O   . GLU A 1 251 ? -26.764 53.760  116.481 1.00 112.30 ? 232 GLU A O   1 
ATOM   487  C CB  . GLU A 1 251 ? -27.107 57.041  117.314 1.00 110.81 ? 232 GLU A CB  1 
ATOM   488  C CG  . GLU A 1 251 ? -26.550 58.238  118.102 1.00 115.68 ? 232 GLU A CG  1 
ATOM   489  C CD  . GLU A 1 251 ? -25.802 59.254  117.220 1.00 119.19 ? 232 GLU A CD  1 
ATOM   490  O OE1 . GLU A 1 251 ? -25.859 59.125  115.968 1.00 120.83 ? 232 GLU A OE1 1 
ATOM   491  O OE2 . GLU A 1 251 ? -25.142 60.162  117.783 1.00 116.08 ? 232 GLU A OE2 1 
ATOM   492  N N   . ALA A 1 252 ? -26.941 55.278  114.805 1.00 109.49 ? 233 ALA A N   1 
ATOM   493  C CA  . ALA A 1 252 ? -27.344 54.301  113.793 1.00 110.35 ? 233 ALA A CA  1 
ATOM   494  C C   . ALA A 1 252 ? -26.459 53.063  113.846 1.00 108.50 ? 233 ALA A C   1 
ATOM   495  O O   . ALA A 1 252 ? -26.950 51.930  113.876 1.00 109.21 ? 233 ALA A O   1 
ATOM   496  C CB  . ALA A 1 252 ? -27.294 54.934  112.397 1.00 103.24 ? 233 ALA A CB  1 
ATOM   497  N N   . THR A 1 253 ? -25.168 53.307  113.933 1.00 104.68 ? 234 THR A N   1 
ATOM   498  C CA  . THR A 1 253 ? -24.236 52.173  113.968 1.00 104.88 ? 234 THR A CA  1 
ATOM   499  C C   . THR A 1 253 ? -24.520 51.352  115.212 1.00 107.65 ? 234 THR A C   1 
ATOM   500  O O   . THR A 1 253 ? -24.780 50.165  115.082 1.00 105.96 ? 234 THR A O   1 
ATOM   501  C CB  . THR A 1 253 ? -22.807 52.688  114.061 1.00 101.91 ? 234 THR A CB  1 
ATOM   502  O OG1 . THR A 1 253 ? -22.444 53.026  112.731 1.00 98.17  ? 234 THR A OG1 1 
ATOM   503  C CG2 . THR A 1 253 ? -21.865 51.629  114.570 1.00 100.76 ? 234 THR A CG2 1 
ATOM   504  N N   . LEU A 1 254 ? -24.545 52.006  116.364 1.00 112.05 ? 235 LEU A N   1 
ATOM   505  C CA  . LEU A 1 254 ? -24.720 51.258  117.628 1.00 112.75 ? 235 LEU A CA  1 
ATOM   506  C C   . LEU A 1 254 ? -26.021 50.469  117.605 1.00 112.38 ? 235 LEU A C   1 
ATOM   507  O O   . LEU A 1 254 ? -25.984 49.313  117.997 1.00 109.89 ? 235 LEU A O   1 
ATOM   508  C CB  . LEU A 1 254 ? -24.674 52.216  118.814 1.00 105.04 ? 235 LEU A CB  1 
ATOM   509  C CG  . LEU A 1 254 ? -24.342 51.530  120.129 1.00 102.93 ? 235 LEU A CG  1 
ATOM   510  C CD1 . LEU A 1 254 ? -23.890 50.116  119.855 1.00 110.38 ? 235 LEU A CD1 1 
ATOM   511  C CD2 . LEU A 1 254 ? -23.263 52.271  120.877 1.00 88.00  ? 235 LEU A CD2 1 
ATOM   512  N N   . GLN A 1 255 ? -27.103 51.090  117.156 1.00 110.90 ? 236 GLN A N   1 
ATOM   513  C CA  . GLN A 1 255 ? -28.410 50.398  117.118 1.00 113.52 ? 236 GLN A CA  1 
ATOM   514  C C   . GLN A 1 255 ? -28.268 49.078  116.366 1.00 119.31 ? 236 GLN A C   1 
ATOM   515  O O   . GLN A 1 255 ? -28.543 48.043  116.971 1.00 121.43 ? 236 GLN A O   1 
ATOM   516  C CB  . GLN A 1 255 ? -29.457 51.284  116.453 1.00 115.44 ? 236 GLN A CB  1 
ATOM   517  C CG  . GLN A 1 255 ? -29.812 52.517  117.266 1.00 120.32 ? 236 GLN A CG  1 
ATOM   518  C CD  . GLN A 1 255 ? -30.818 53.392  116.560 1.00 128.58 ? 236 GLN A CD  1 
ATOM   519  O OE1 . GLN A 1 255 ? -31.548 52.944  115.686 1.00 129.74 ? 236 GLN A OE1 1 
ATOM   520  N NE2 . GLN A 1 255 ? -30.865 54.659  116.935 1.00 126.73 ? 236 GLN A NE2 1 
ATOM   521  N N   . GLN A 1 256 ? -27.745 49.112  115.140 1.00 116.16 ? 237 GLN A N   1 
ATOM   522  C CA  . GLN A 1 256 ? -27.635 47.886  114.307 1.00 115.89 ? 237 GLN A CA  1 
ATOM   523  C C   . GLN A 1 256 ? -26.568 46.945  114.845 1.00 116.23 ? 237 GLN A C   1 
ATOM   524  O O   . GLN A 1 256 ? -26.647 45.764  114.564 1.00 116.90 ? 237 GLN A O   1 
ATOM   525  C CB  . GLN A 1 256 ? -27.277 48.228  112.872 1.00 112.44 ? 237 GLN A CB  1 
ATOM   526  C CG  . GLN A 1 256 ? -28.421 48.023  111.907 1.00 113.73 ? 237 GLN A CG  1 
ATOM   527  C CD  . GLN A 1 256 ? -28.800 49.360  111.336 1.00 122.95 ? 237 GLN A CD  1 
ATOM   528  O OE1 . GLN A 1 256 ? -28.779 50.367  112.029 1.00 121.68 ? 237 GLN A OE1 1 
ATOM   529  N NE2 . GLN A 1 256 ? -29.133 49.384  110.058 1.00 120.89 ? 237 GLN A NE2 1 
ATOM   530  N N   . LEU A 1 257 ? -25.586 47.462  115.563 1.00 112.97 ? 238 LEU A N   1 
ATOM   531  C CA  . LEU A 1 257 ? -24.539 46.584  116.119 1.00 117.13 ? 238 LEU A CA  1 
ATOM   532  C C   . LEU A 1 257 ? -25.168 45.726  117.214 1.00 126.34 ? 238 LEU A C   1 
ATOM   533  O O   . LEU A 1 257 ? -26.035 46.234  117.928 1.00 127.01 ? 238 LEU A O   1 
ATOM   534  C CB  . LEU A 1 257 ? -23.472 47.505  116.697 1.00 117.08 ? 238 LEU A CB  1 
ATOM   535  C CG  . LEU A 1 257 ? -22.057 46.954  116.683 1.00 119.17 ? 238 LEU A CG  1 
ATOM   536  C CD1 . LEU A 1 257 ? -21.063 48.080  116.811 1.00 111.53 ? 238 LEU A CD1 1 
ATOM   537  C CD2 . LEU A 1 257 ? -21.880 46.005  117.834 1.00 119.20 ? 238 LEU A CD2 1 
ATOM   538  N N   . GLU A 1 258 ? -24.712 44.488  117.381 1.00 128.88 ? 239 GLU A N   1 
ATOM   539  C CA  . GLU A 1 258 ? -25.327 43.604  118.401 1.00 125.76 ? 239 GLU A CA  1 
ATOM   540  C C   . GLU A 1 258 ? -24.301 43.187  119.453 1.00 124.60 ? 239 GLU A C   1 
ATOM   541  O O   . GLU A 1 258 ? -23.119 43.399  119.249 1.00 125.62 ? 239 GLU A O   1 
ATOM   542  C CB  . GLU A 1 258 ? -25.926 42.369  117.734 1.00 129.03 ? 239 GLU A CB  1 
ATOM   543  C CG  . GLU A 1 258 ? -25.878 42.427  116.218 1.00 128.79 ? 239 GLU A CG  1 
ATOM   544  C CD  . GLU A 1 258 ? -24.481 42.427  115.626 1.00 136.51 ? 239 GLU A CD  1 
ATOM   545  O OE1 . GLU A 1 258 ? -24.359 42.346  114.393 1.00 138.57 ? 239 GLU A OE1 1 
ATOM   546  O OE2 . GLU A 1 258 ? -23.524 42.524  116.408 1.00 137.47 ? 239 GLU A OE2 1 
ATOM   547  N N   . ALA A 1 259 ? -24.772 42.585  120.538 1.00 124.69 ? 240 ALA A N   1 
ATOM   548  C CA  . ALA A 1 259 ? -23.899 42.143  121.639 1.00 115.51 ? 240 ALA A CA  1 
ATOM   549  C C   . ALA A 1 259 ? -23.200 40.867  121.213 1.00 113.58 ? 240 ALA A C   1 
ATOM   550  O O   . ALA A 1 259 ? -23.733 40.166  120.383 1.00 118.54 ? 240 ALA A O   1 
ATOM   551  C CB  . ALA A 1 259 ? -24.743 41.912  122.856 1.00 107.59 ? 240 ALA A CB  1 
ATOM   552  N N   . PRO A 1 260 ? -21.987 40.589  121.707 1.00 111.55 ? 241 PRO A N   1 
ATOM   553  C CA  . PRO A 1 260 ? -21.407 41.339  122.809 1.00 114.26 ? 241 PRO A CA  1 
ATOM   554  C C   . PRO A 1 260 ? -20.580 42.524  122.309 1.00 121.18 ? 241 PRO A C   1 
ATOM   555  O O   . PRO A 1 260 ? -20.020 43.241  123.092 1.00 120.16 ? 241 PRO A O   1 
ATOM   556  C CB  . PRO A 1 260 ? -20.413 40.314  123.334 1.00 110.51 ? 241 PRO A CB  1 
ATOM   557  C CG  . PRO A 1 260 ? -19.895 39.689  122.081 1.00 110.93 ? 241 PRO A CG  1 
ATOM   558  C CD  . PRO A 1 260 ? -21.130 39.525  121.230 1.00 106.59 ? 241 PRO A CD  1 
ATOM   559  N N   . TYR A 1 261 ? -20.572 42.716  120.997 1.00 120.77 ? 242 TYR A N   1 
ATOM   560  C CA  . TYR A 1 261 ? -19.795 43.785  120.341 1.00 117.42 ? 242 TYR A CA  1 
ATOM   561  C C   . TYR A 1 261 ? -20.335 45.158  120.717 1.00 119.42 ? 242 TYR A C   1 
ATOM   562  O O   . TYR A 1 261 ? -19.555 46.092  120.746 1.00 117.73 ? 242 TYR A O   1 
ATOM   563  C CB  . TYR A 1 261 ? -19.800 43.516  118.843 1.00 115.43 ? 242 TYR A CB  1 
ATOM   564  C CG  . TYR A 1 261 ? -19.175 42.189  118.527 1.00 113.67 ? 242 TYR A CG  1 
ATOM   565  C CD1 . TYR A 1 261 ? -19.735 41.327  117.613 1.00 113.45 ? 242 TYR A CD1 1 
ATOM   566  C CD2 . TYR A 1 261 ? -18.031 41.789  119.178 1.00 111.11 ? 242 TYR A CD2 1 
ATOM   567  C CE1 . TYR A 1 261 ? -19.159 40.101  117.339 1.00 119.22 ? 242 TYR A CE1 1 
ATOM   568  C CE2 . TYR A 1 261 ? -17.438 40.572  118.911 1.00 112.28 ? 242 TYR A CE2 1 
ATOM   569  C CZ  . TYR A 1 261 ? -18.003 39.722  117.988 1.00 118.66 ? 242 TYR A CZ  1 
ATOM   570  O OH  . TYR A 1 261 ? -17.419 38.520  117.725 1.00 115.29 ? 242 TYR A OH  1 
ATOM   571  N N   . ASN A 1 262 ? -21.628 45.283  121.001 1.00 121.07 ? 243 ASN A N   1 
ATOM   572  C CA  . ASN A 1 262 ? -22.152 46.619  121.363 1.00 118.57 ? 243 ASN A CA  1 
ATOM   573  C C   . ASN A 1 262 ? -22.195 46.790  122.878 1.00 115.01 ? 243 ASN A C   1 
ATOM   574  O O   . ASN A 1 262 ? -23.194 47.281  123.360 1.00 116.62 ? 243 ASN A O   1 
ATOM   575  C CB  . ASN A 1 262 ? -23.530 46.862  120.767 1.00 115.78 ? 243 ASN A CB  1 
ATOM   576  C CG  . ASN A 1 262 ? -24.597 46.006  121.397 1.00 119.74 ? 243 ASN A CG  1 
ATOM   577  O OD1 . ASN A 1 262 ? -24.327 45.251  122.317 1.00 115.72 ? 243 ASN A OD1 1 
ATOM   578  N ND2 . ASN A 1 262 ? -25.811 46.123  120.897 1.00 122.01 ? 243 ASN A ND2 1 
ATOM   579  N N   . SER A 1 263 ? -21.146 46.398  123.585 1.00 112.21 ? 244 SER A N   1 
ATOM   580  C CA  . SER A 1 263 ? -21.126 46.544  125.052 1.00 118.80 ? 244 SER A CA  1 
ATOM   581  C C   . SER A 1 263 ? -20.252 47.736  125.399 1.00 117.53 ? 244 SER A C   1 
ATOM   582  O O   . SER A 1 263 ? -20.576 48.449  126.339 1.00 117.86 ? 244 SER A O   1 
ATOM   583  C CB  . SER A 1 263 ? -20.564 45.312  125.664 1.00 119.15 ? 244 SER A CB  1 
ATOM   584  O OG  . SER A 1 263 ? -19.151 45.369  125.681 1.00 115.90 ? 244 SER A OG  1 
ATOM   585  N N   . ASP A 1 264 ? -19.179 47.880  124.635 1.00 116.91 ? 245 ASP A N   1 
ATOM   586  C CA  . ASP A 1 264 ? -18.187 48.946  124.878 1.00 108.92 ? 245 ASP A CA  1 
ATOM   587  C C   . ASP A 1 264 ? -18.459 50.118  123.958 1.00 100.69 ? 245 ASP A C   1 
ATOM   588  O O   . ASP A 1 264 ? -17.745 50.271  123.001 1.00 100.30 ? 245 ASP A O   1 
ATOM   589  C CB  . ASP A 1 264 ? -16.779 48.432  124.620 1.00 100.98 ? 245 ASP A CB  1 
ATOM   590  C CG  . ASP A 1 264 ? -15.771 49.386  125.191 1.00 102.91 ? 245 ASP A CG  1 
ATOM   591  O OD1 . ASP A 1 264 ? -16.161 50.519  125.435 1.00 99.31  ? 245 ASP A OD1 1 
ATOM   592  O OD2 . ASP A 1 264 ? -14.633 48.974  125.405 1.00 102.90 ? 245 ASP A OD2 1 
ATOM   593  N N   . THR A 1 265 ? -19.415 50.956  124.316 1.00 100.55 ? 246 THR A N   1 
ATOM   594  C CA  . THR A 1 265 ? -19.798 52.105  123.472 1.00 100.99 ? 246 THR A CA  1 
ATOM   595  C C   . THR A 1 265 ? -18.599 52.976  123.104 1.00 101.95 ? 246 THR A C   1 
ATOM   596  O O   . THR A 1 265 ? -18.552 53.416  121.968 1.00 100.46 ? 246 THR A O   1 
ATOM   597  C CB  . THR A 1 265 ? -20.808 52.959  124.219 1.00 101.51 ? 246 THR A CB  1 
ATOM   598  O OG1 . THR A 1 265 ? -20.021 53.513  125.262 1.00 110.52 ? 246 THR A OG1 1 
ATOM   599  C CG2 . THR A 1 265 ? -21.886 52.123  124.852 1.00 104.67 ? 246 THR A CG2 1 
ATOM   600  N N   . VAL A 1 266 ? -17.675 53.197  124.028 1.00 99.12  ? 247 VAL A N   1 
ATOM   601  C CA  . VAL A 1 266 ? -16.505 54.057  123.707 1.00 97.64  ? 247 VAL A CA  1 
ATOM   602  C C   . VAL A 1 266 ? -15.788 53.478  122.498 1.00 96.95  ? 247 VAL A C   1 
ATOM   603  O O   . VAL A 1 266 ? -15.647 54.187  121.525 1.00 94.10  ? 247 VAL A O   1 
ATOM   604  C CB  . VAL A 1 266 ? -15.550 54.146  124.897 1.00 89.80  ? 247 VAL A CB  1 
ATOM   605  C CG1 . VAL A 1 266 ? -15.712 55.467  125.606 1.00 93.28  ? 247 VAL A CG1 1 
ATOM   606  C CG2 . VAL A 1 266 ? -15.783 52.998  125.854 1.00 95.27  ? 247 VAL A CG2 1 
ATOM   607  N N   . LEU A 1 267 ? -15.446 52.199  122.543 1.00 95.45  ? 248 LEU A N   1 
ATOM   608  C CA  . LEU A 1 267 ? -14.740 51.555  121.414 1.00 91.25  ? 248 LEU A CA  1 
ATOM   609  C C   . LEU A 1 267 ? -15.545 51.733  120.137 1.00 90.99  ? 248 LEU A C   1 
ATOM   610  O O   . LEU A 1 267 ? -14.975 52.116  119.156 1.00 88.94  ? 248 LEU A O   1 
ATOM   611  C CB  . LEU A 1 267 ? -14.573 50.077  121.720 1.00 86.68  ? 248 LEU A CB  1 
ATOM   612  C CG  . LEU A 1 267 ? -13.607 49.376  120.788 1.00 86.95  ? 248 LEU A CG  1 
ATOM   613  C CD1 . LEU A 1 267 ? -12.197 49.589  121.262 1.00 93.10  ? 248 LEU A CD1 1 
ATOM   614  C CD2 . LEU A 1 267 ? -13.909 47.904  120.728 1.00 83.74  ? 248 LEU A CD2 1 
ATOM   615  N N   . VAL A 1 268 ? -16.843 51.495  120.172 1.00 90.21  ? 249 VAL A N   1 
ATOM   616  C CA  . VAL A 1 268 ? -17.634 51.712  118.938 1.00 86.95  ? 249 VAL A CA  1 
ATOM   617  C C   . VAL A 1 268 ? -17.535 53.178  118.561 1.00 82.59  ? 249 VAL A C   1 
ATOM   618  O O   . VAL A 1 268 ? -17.325 53.459  117.420 1.00 83.71  ? 249 VAL A O   1 
ATOM   619  C CB  . VAL A 1 268 ? -19.099 51.335  119.146 1.00 89.62  ? 249 VAL A CB  1 
ATOM   620  C CG1 . VAL A 1 268 ? -19.983 52.177  118.263 1.00 87.22  ? 249 VAL A CG1 1 
ATOM   621  C CG2 . VAL A 1 268 ? -19.332 49.874  118.865 1.00 94.65  ? 249 VAL A CG2 1 
ATOM   622  N N   . HIS A 1 269 ? -17.669 54.073  119.520 1.00 89.56  ? 250 HIS A N   1 
ATOM   623  C CA  . HIS A 1 269 ? -17.594 55.498  119.137 1.00 92.66  ? 250 HIS A CA  1 
ATOM   624  C C   . HIS A 1 269 ? -16.197 55.773  118.617 1.00 93.18  ? 250 HIS A C   1 
ATOM   625  O O   . HIS A 1 269 ? -16.070 56.486  117.644 1.00 92.88  ? 250 HIS A O   1 
ATOM   626  C CB  . HIS A 1 269 ? -17.876 56.392  120.332 1.00 89.83  ? 250 HIS A CB  1 
ATOM   627  C CG  . HIS A 1 269 ? -17.880 57.837  119.989 1.00 92.36  ? 250 HIS A CG  1 
ATOM   628  N ND1 . HIS A 1 269 ? -18.888 58.403  119.280 1.00 89.99  ? 250 HIS A ND1 1 
ATOM   629  C CD2 . HIS A 1 269 ? -17.014 58.825  120.264 1.00 90.76  ? 250 HIS A CD2 1 
ATOM   630  C CE1 . HIS A 1 269 ? -18.654 59.680  119.128 1.00 87.54  ? 250 HIS A CE1 1 
ATOM   631  N NE2 . HIS A 1 269 ? -17.518 59.961  119.719 1.00 87.97  ? 250 HIS A NE2 1 
ATOM   632  N N   . ARG A 1 270 ? -15.193 55.207  119.268 1.00 92.34  ? 251 ARG A N   1 
ATOM   633  C CA  . ARG A 1 270 ? -13.797 55.429  118.836 1.00 91.20  ? 251 ARG A CA  1 
ATOM   634  C C   . ARG A 1 270 ? -13.655 54.939  117.398 1.00 88.75  ? 251 ARG A C   1 
ATOM   635  O O   . ARG A 1 270 ? -13.170 55.665  116.570 1.00 90.23  ? 251 ARG A O   1 
ATOM   636  C CB  . ARG A 1 270 ? -12.864 54.651  119.759 1.00 83.27  ? 251 ARG A CB  1 
ATOM   637  C CG  . ARG A 1 270 ? -11.693 55.451  120.290 1.00 75.44  ? 251 ARG A CG  1 
ATOM   638  C CD  . ARG A 1 270 ? -11.036 54.612  121.343 1.00 81.08  ? 251 ARG A CD  1 
ATOM   639  N NE  . ARG A 1 270 ? -9.641  54.334  121.083 1.00 89.43  ? 251 ARG A NE  1 
ATOM   640  C CZ  . ARG A 1 270 ? -8.940  53.468  121.786 1.00 87.65  ? 251 ARG A CZ  1 
ATOM   641  N NH1 . ARG A 1 270 ? -9.518  52.811  122.767 1.00 80.43  ? 251 ARG A NH1 1 
ATOM   642  N NH2 . ARG A 1 270 ? -7.674  53.244  121.525 1.00 83.84  ? 251 ARG A NH2 1 
ATOM   643  N N   . VAL A 1 271 ? -14.123 53.737  117.120 1.00 86.05  ? 252 VAL A N   1 
ATOM   644  C CA  . VAL A 1 271 ? -13.964 53.169  115.761 1.00 81.52  ? 252 VAL A CA  1 
ATOM   645  C C   . VAL A 1 271 ? -14.718 54.012  114.753 1.00 80.92  ? 252 VAL A C   1 
ATOM   646  O O   . VAL A 1 271 ? -14.114 54.443  113.808 1.00 82.87  ? 252 VAL A O   1 
ATOM   647  C CB  . VAL A 1 271 ? -14.460 51.722  115.735 1.00 84.30  ? 252 VAL A CB  1 
ATOM   648  C CG1 . VAL A 1 271 ? -14.913 51.316  114.359 1.00 78.88  ? 252 VAL A CG1 1 
ATOM   649  C CG2 . VAL A 1 271 ? -13.397 50.778  116.237 1.00 84.07  ? 252 VAL A CG2 1 
ATOM   650  N N   . HIS A 1 272 ? -15.980 54.304  115.004 1.00 80.81  ? 253 HIS A N   1 
ATOM   651  C CA  . HIS A 1 272 ? -16.775 55.039  113.999 1.00 77.58  ? 253 HIS A CA  1 
ATOM   652  C C   . HIS A 1 272 ? -16.159 56.387  113.694 1.00 83.73  ? 253 HIS A C   1 
ATOM   653  O O   . HIS A 1 272 ? -16.171 56.761  112.556 1.00 86.90  ? 253 HIS A O   1 
ATOM   654  C CB  . HIS A 1 272 ? -18.215 55.170  114.454 1.00 78.12  ? 253 HIS A CB  1 
ATOM   655  C CG  . HIS A 1 272 ? -19.016 56.080  113.604 1.00 76.48  ? 253 HIS A CG  1 
ATOM   656  N ND1 . HIS A 1 272 ? -18.685 57.376  113.426 1.00 87.10  ? 253 HIS A ND1 1 
ATOM   657  C CD2 . HIS A 1 272 ? -20.137 55.881  112.904 1.00 87.13  ? 253 HIS A CD2 1 
ATOM   658  C CE1 . HIS A 1 272 ? -19.566 57.949  112.652 1.00 89.50  ? 253 HIS A CE1 1 
ATOM   659  N NE2 . HIS A 1 272 ? -20.453 57.053  112.308 1.00 94.71  ? 253 HIS A NE2 1 
ATOM   660  N N   . SER A 1 273 ? -15.654 57.097  114.683 1.00 87.57  ? 254 SER A N   1 
ATOM   661  C CA  . SER A 1 273 ? -15.044 58.399  114.349 1.00 90.05  ? 254 SER A CA  1 
ATOM   662  C C   . SER A 1 273 ? -13.862 58.169  113.419 1.00 87.79  ? 254 SER A C   1 
ATOM   663  O O   . SER A 1 273 ? -13.803 58.809  112.385 1.00 88.76  ? 254 SER A O   1 
ATOM   664  C CB  . SER A 1 273 ? -14.654 59.088  115.585 1.00 88.86  ? 254 SER A CB  1 
ATOM   665  O OG  . SER A 1 273 ? -15.729 59.017  116.489 1.00 91.89  ? 254 SER A OG  1 
ATOM   666  N N   . TYR A 1 274 ? -13.003 57.219  113.754 1.00 84.74  ? 255 TYR A N   1 
ATOM   667  C CA  . TYR A 1 274 ? -11.818 56.910  112.925 1.00 84.28  ? 255 TYR A CA  1 
ATOM   668  C C   . TYR A 1 274 ? -12.234 56.630  111.492 1.00 79.90  ? 255 TYR A C   1 
ATOM   669  O O   . TYR A 1 274 ? -11.666 57.176  110.593 1.00 78.10  ? 255 TYR A O   1 
ATOM   670  C CB  . TYR A 1 274 ? -11.153 55.654  113.455 1.00 83.03  ? 255 TYR A CB  1 
ATOM   671  C CG  . TYR A 1 274 ? -10.328 54.920  112.446 1.00 84.49  ? 255 TYR A CG  1 
ATOM   672  C CD1 . TYR A 1 274 ? -9.082  55.373  112.087 1.00 85.49  ? 255 TYR A CD1 1 
ATOM   673  C CD2 . TYR A 1 274 ? -10.784 53.756  111.879 1.00 87.51  ? 255 TYR A CD2 1 
ATOM   674  C CE1 . TYR A 1 274 ? -8.309  54.691  111.173 1.00 88.20  ? 255 TYR A CE1 1 
ATOM   675  C CE2 . TYR A 1 274 ? -10.027 53.062  110.962 1.00 92.62  ? 255 TYR A CE2 1 
ATOM   676  C CZ  . TYR A 1 274 ? -8.788  53.535  110.603 1.00 98.47  ? 255 TYR A CZ  1 
ATOM   677  O OH  . TYR A 1 274 ? -8.046  52.843  109.696 1.00 101.62 ? 255 TYR A OH  1 
ATOM   678  N N   . LEU A 1 275 ? -13.238 55.800  111.304 1.00 78.34  ? 256 LEU A N   1 
ATOM   679  C CA  . LEU A 1 275 ? -13.699 55.514  109.936 1.00 77.82  ? 256 LEU A CA  1 
ATOM   680  C C   . LEU A 1 275 ? -14.161 56.815  109.310 1.00 76.66  ? 256 LEU A C   1 
ATOM   681  O O   . LEU A 1 275 ? -13.799 57.091  108.220 1.00 80.40  ? 256 LEU A O   1 
ATOM   682  C CB  . LEU A 1 275 ? -14.885 54.566  110.046 1.00 79.64  ? 256 LEU A CB  1 
ATOM   683  C CG  . LEU A 1 275 ? -14.563 53.091  109.874 1.00 80.53  ? 256 LEU A CG  1 
ATOM   684  C CD1 . LEU A 1 275 ? -13.110 52.901  109.559 1.00 84.32  ? 256 LEU A CD1 1 
ATOM   685  C CD2 . LEU A 1 275 ? -14.893 52.339  111.125 1.00 83.97  ? 256 LEU A CD2 1 
ATOM   686  N N   . GLU A 1 276 ? -14.951 57.583  110.025 1.00 79.85  ? 257 GLU A N   1 
ATOM   687  C CA  . GLU A 1 276 ? -15.474 58.835  109.459 1.00 81.70  ? 257 GLU A CA  1 
ATOM   688  C C   . GLU A 1 276 ? -14.331 59.789  109.155 1.00 81.26  ? 257 GLU A C   1 
ATOM   689  O O   . GLU A 1 276 ? -14.392 60.444  108.156 1.00 78.41  ? 257 GLU A O   1 
ATOM   690  C CB  . GLU A 1 276 ? -16.359 59.469  110.518 1.00 86.98  ? 257 GLU A CB  1 
ATOM   691  C CG  . GLU A 1 276 ? -17.599 60.134  109.980 1.00 94.94  ? 257 GLU A CG  1 
ATOM   692  C CD  . GLU A 1 276 ? -18.191 61.081  110.999 1.00 102.99 ? 257 GLU A CD  1 
ATOM   693  O OE1 . GLU A 1 276 ? -17.611 61.192  112.075 1.00 106.67 ? 257 GLU A OE1 1 
ATOM   694  O OE2 . GLU A 1 276 ? -19.215 61.699  110.712 1.00 101.02 ? 257 GLU A OE2 1 
ATOM   695  N N   . ARG A 1 277 ? -13.337 59.872  110.018 1.00 79.09  ? 258 ARG A N   1 
ATOM   696  C CA  . ARG A 1 277 ? -12.263 60.856  109.780 1.00 80.55  ? 258 ARG A CA  1 
ATOM   697  C C   . ARG A 1 277 ? -11.532 60.524  108.495 1.00 82.03  ? 258 ARG A C   1 
ATOM   698  O O   . ARG A 1 277 ? -11.279 61.415  107.733 1.00 79.12  ? 258 ARG A O   1 
ATOM   699  C CB  . ARG A 1 277 ? -11.254 60.814  110.922 1.00 79.25  ? 258 ARG A CB  1 
ATOM   700  C CG  . ARG A 1 277 ? -10.433 62.081  111.070 1.00 76.94  ? 258 ARG A CG  1 
ATOM   701  C CD  . ARG A 1 277 ? -11.250 63.201  110.496 1.00 79.63  ? 258 ARG A CD  1 
ATOM   702  N NE  . ARG A 1 277 ? -11.920 63.964  111.521 1.00 77.65  ? 258 ARG A NE  1 
ATOM   703  C CZ  . ARG A 1 277 ? -11.295 64.469  112.550 1.00 79.06  ? 258 ARG A CZ  1 
ATOM   704  N NH1 . ARG A 1 277 ? -10.002 64.278  112.683 1.00 76.10  ? 258 ARG A NH1 1 
ATOM   705  N NH2 . ARG A 1 277 ? -11.960 65.146  113.451 1.00 77.94  ? 258 ARG A NH2 1 
ATOM   706  N N   . HIS A 1 278 ? -11.231 59.262  108.270 1.00 77.33  ? 259 HIS A N   1 
ATOM   707  C CA  . HIS A 1 278 ? -10.418 58.933  107.116 1.00 78.30  ? 259 HIS A CA  1 
ATOM   708  C C   . HIS A 1 278 ? -11.231 58.457  105.939 1.00 79.18  ? 259 HIS A C   1 
ATOM   709  O O   . HIS A 1 278 ? -10.759 57.609  105.176 1.00 81.42  ? 259 HIS A O   1 
ATOM   710  C CB  . HIS A 1 278 ? -9.376  57.905  107.503 1.00 78.62  ? 259 HIS A CB  1 
ATOM   711  C CG  . HIS A 1 278 ? -8.462  58.404  108.552 1.00 80.33  ? 259 HIS A CG  1 
ATOM   712  N ND1 . HIS A 1 278 ? -8.485  57.931  109.843 1.00 84.73  ? 259 HIS A ND1 1 
ATOM   713  C CD2 . HIS A 1 278 ? -7.565  59.414  108.532 1.00 84.66  ? 259 HIS A CD2 1 
ATOM   714  C CE1 . HIS A 1 278 ? -7.578  58.575  110.555 1.00 88.67  ? 259 HIS A CE1 1 
ATOM   715  N NE2 . HIS A 1 278 ? -7.012  59.487  109.785 1.00 91.21  ? 259 HIS A NE2 1 
ATOM   716  N N   . GLY A 1 279 ? -12.432 58.989  105.768 1.00 80.44  ? 260 GLY A N   1 
ATOM   717  C CA  . GLY A 1 279 ? -13.198 58.789  104.559 1.00 79.38  ? 260 GLY A CA  1 
ATOM   718  C C   . GLY A 1 279 ? -13.475 57.345  104.196 1.00 85.72  ? 260 GLY A C   1 
ATOM   719  O O   . GLY A 1 279 ? -13.692 57.047  103.015 1.00 87.91  ? 260 GLY A O   1 
ATOM   720  N N   . LEU A 1 280 ? -13.444 56.425  105.168 1.00 76.84  ? 261 LEU A N   1 
ATOM   721  C CA  . LEU A 1 280 ? -13.873 55.070  104.850 1.00 75.87  ? 261 LEU A CA  1 
ATOM   722  C C   . LEU A 1 280 ? -15.386 54.943  104.868 1.00 80.69  ? 261 LEU A C   1 
ATOM   723  O O   . LEU A 1 280 ? -15.929 54.037  104.229 1.00 80.47  ? 261 LEU A O   1 
ATOM   724  C CB  . LEU A 1 280 ? -13.230 54.070  105.804 1.00 73.42  ? 261 LEU A CB  1 
ATOM   725  C CG  . LEU A 1 280 ? -11.750 53.915  105.478 1.00 73.79  ? 261 LEU A CG  1 
ATOM   726  C CD1 . LEU A 1 280 ? -11.011 53.061  106.492 1.00 72.26  ? 261 LEU A CD1 1 
ATOM   727  C CD2 . LEU A 1 280 ? -11.600 53.338  104.083 1.00 80.59  ? 261 LEU A CD2 1 
ATOM   728  N N   . ILE A 1 281 ? -16.070 55.852  105.561 1.00 82.02  ? 262 ILE A N   1 
ATOM   729  C CA  . ILE A 1 281 ? -17.522 55.891  105.644 1.00 79.88  ? 262 ILE A CA  1 
ATOM   730  C C   . ILE A 1 281 ? -17.912 57.357  105.601 1.00 80.63  ? 262 ILE A C   1 
ATOM   731  O O   . ILE A 1 281 ? -17.115 58.237  105.935 1.00 85.01  ? 262 ILE A O   1 
ATOM   732  C CB  . ILE A 1 281 ? -18.053 55.229  106.930 1.00 79.73  ? 262 ILE A CB  1 
ATOM   733  C CG1 . ILE A 1 281 ? -17.522 55.989  108.141 1.00 83.73  ? 262 ILE A CG1 1 
ATOM   734  C CG2 . ILE A 1 281 ? -17.588 53.763  107.019 1.00 80.77  ? 262 ILE A CG2 1 
ATOM   735  C CD1 . ILE A 1 281 ? -18.183 55.631  109.444 1.00 80.94  ? 262 ILE A CD1 1 
ATOM   736  N N   . ASN A 1 282 ? -19.140 57.627  105.160 1.00 83.88  ? 263 ASN A N   1 
ATOM   737  C CA  . ASN A 1 282 ? -19.657 58.998  105.098 1.00 86.10  ? 263 ASN A CA  1 
ATOM   738  C C   . ASN A 1 282 ? -18.730 59.877  104.270 1.00 83.44  ? 263 ASN A C   1 
ATOM   739  O O   . ASN A 1 282 ? -18.247 60.922  104.714 1.00 87.86  ? 263 ASN A O   1 
ATOM   740  C CB  . ASN A 1 282 ? -19.834 59.576  106.498 1.00 89.11  ? 263 ASN A CB  1 
ATOM   741  C CG  . ASN A 1 282 ? -20.802 58.796  107.319 1.00 88.60  ? 263 ASN A CG  1 
ATOM   742  O OD1 . ASN A 1 282 ? -21.974 58.671  106.979 1.00 92.32  ? 263 ASN A OD1 1 
ATOM   743  N ND2 . ASN A 1 282 ? -20.305 58.221  108.401 1.00 93.49  ? 263 ASN A ND2 1 
ATOM   744  N N   . PHE A 1 283 ? -18.424 59.395  103.082 1.00 82.55  ? 264 PHE A N   1 
ATOM   745  C CA  . PHE A 1 283 ? -17.641 60.126  102.107 1.00 83.01  ? 264 PHE A CA  1 
ATOM   746  C C   . PHE A 1 283 ? -18.424 60.130  100.808 1.00 84.38  ? 264 PHE A C   1 
ATOM   747  O O   . PHE A 1 283 ? -19.324 59.313  100.598 1.00 85.41  ? 264 PHE A O   1 
ATOM   748  C CB  . PHE A 1 283 ? -16.255 59.498  101.904 1.00 78.19  ? 264 PHE A CB  1 
ATOM   749  C CG  . PHE A 1 283 ? -16.282 58.191  101.153 1.00 82.30  ? 264 PHE A CG  1 
ATOM   750  C CD1 . PHE A 1 283 ? -16.113 58.153  99.771  1.00 81.21  ? 264 PHE A CD1 1 
ATOM   751  C CD2 . PHE A 1 283 ? -16.470 56.992  101.822 1.00 85.65  ? 264 PHE A CD2 1 
ATOM   752  C CE1 . PHE A 1 283 ? -16.138 56.934  99.063  1.00 75.60  ? 264 PHE A CE1 1 
ATOM   753  C CE2 . PHE A 1 283 ? -16.491 55.772  101.120 1.00 87.46  ? 264 PHE A CE2 1 
ATOM   754  C CZ  . PHE A 1 283 ? -16.323 55.753  99.733  1.00 78.85  ? 264 PHE A CZ  1 
ATOM   755  N N   . GLY A 1 284 ? -18.083 61.042  99.932  1.00 78.22  ? 265 GLY A N   1 
ATOM   756  C CA  . GLY A 1 284 ? -18.791 61.147  98.674  1.00 80.66  ? 265 GLY A CA  1 
ATOM   757  C C   . GLY A 1 284 ? -19.961 62.083  98.817  1.00 85.00  ? 265 GLY A C   1 
ATOM   758  O O   . GLY A 1 284 ? -19.825 63.162  99.377  1.00 93.02  ? 265 GLY A O   1 
ATOM   759  N N   . ILE A 1 285 ? -21.120 61.667  98.323  1.00 85.24  ? 266 ILE A N   1 
ATOM   760  C CA  . ILE A 1 285 ? -22.292 62.523  98.304  1.00 86.02  ? 266 ILE A CA  1 
ATOM   761  C C   . ILE A 1 285 ? -23.417 61.783  99.009  1.00 95.23  ? 266 ILE A C   1 
ATOM   762  O O   . ILE A 1 285 ? -23.942 60.790  98.488  1.00 97.64  ? 266 ILE A O   1 
ATOM   763  C CB  . ILE A 1 285 ? -22.691 62.892  96.884  1.00 80.04  ? 266 ILE A CB  1 
ATOM   764  C CG1 . ILE A 1 285 ? -21.503 63.539  96.206  1.00 87.09  ? 266 ILE A CG1 1 
ATOM   765  C CG2 . ILE A 1 285 ? -23.773 63.930  96.926  1.00 82.36  ? 266 ILE A CG2 1 
ATOM   766  C CD1 . ILE A 1 285 ? -21.660 63.667  94.711  1.00 86.13  ? 266 ILE A CD1 1 
ATOM   767  N N   . TYR A 1 286 ? -23.796 62.270  100.187 1.00 96.23  ? 267 TYR A N   1 
ATOM   768  C CA  . TYR A 1 286 ? -24.766 61.605  101.041 1.00 97.84  ? 267 TYR A CA  1 
ATOM   769  C C   . TYR A 1 286 ? -25.636 62.673  101.676 1.00 106.80 ? 267 TYR A C   1 
ATOM   770  O O   . TYR A 1 286 ? -25.144 63.770  101.963 1.00 113.57 ? 267 TYR A O   1 
ATOM   771  C CB  . TYR A 1 286 ? -24.045 60.735  102.090 1.00 94.45  ? 267 TYR A CB  1 
ATOM   772  C CG  . TYR A 1 286 ? -22.889 61.414  102.822 1.00 99.19  ? 267 TYR A CG  1 
ATOM   773  C CD1 . TYR A 1 286 ? -21.642 61.549  102.220 1.00 98.16  ? 267 TYR A CD1 1 
ATOM   774  C CD2 . TYR A 1 286 ? -23.011 61.837  104.147 1.00 99.83  ? 267 TYR A CD2 1 
ATOM   775  C CE1 . TYR A 1 286 ? -20.565 62.153  102.878 1.00 99.11  ? 267 TYR A CE1 1 
ATOM   776  C CE2 . TYR A 1 286 ? -21.926 62.431  104.822 1.00 97.63  ? 267 TYR A CE2 1 
ATOM   777  C CZ  . TYR A 1 286 ? -20.709 62.584  104.182 1.00 97.49  ? 267 TYR A CZ  1 
ATOM   778  O OH  . TYR A 1 286 ? -19.621 63.164  104.820 1.00 94.42  ? 267 TYR A OH  1 
ATOM   779  N N   . LYS A 1 287 ? -26.902 62.340  101.901 1.00 109.33 ? 268 LYS A N   1 
ATOM   780  C CA  . LYS A 1 287 ? -27.796 63.267  102.623 1.00 115.49 ? 268 LYS A CA  1 
ATOM   781  C C   . LYS A 1 287 ? -27.401 63.101  104.078 1.00 110.44 ? 268 LYS A C   1 
ATOM   782  O O   . LYS A 1 287 ? -27.368 61.974  104.526 1.00 102.92 ? 268 LYS A O   1 
ATOM   783  C CB  . LYS A 1 287 ? -29.256 62.851  102.458 1.00 116.53 ? 268 LYS A CB  1 
ATOM   784  C CG  . LYS A 1 287 ? -30.259 63.739  103.180 1.00 124.66 ? 268 LYS A CG  1 
ATOM   785  C CD  . LYS A 1 287 ? -31.700 63.329  102.972 1.00 122.21 ? 268 LYS A CD  1 
ATOM   786  C CE  . LYS A 1 287 ? -32.687 64.392  103.399 1.00 118.98 ? 268 LYS A CE  1 
ATOM   787  N NZ  . LYS A 1 287 ? -32.830 65.448  102.371 1.00 119.18 ? 268 LYS A NZ  1 
ATOM   788  N N   . ARG A 1 288 ? -27.075 64.179  104.771 1.00 115.38 ? 269 ARG A N   1 
ATOM   789  C CA  . ARG A 1 288 ? -26.615 63.976  106.157 1.00 115.77 ? 269 ARG A CA  1 
ATOM   790  C C   . ARG A 1 288 ? -27.801 64.065  107.090 1.00 119.55 ? 269 ARG A C   1 
ATOM   791  O O   . ARG A 1 288 ? -28.666 64.881  106.841 1.00 124.86 ? 269 ARG A O   1 
ATOM   792  C CB  . ARG A 1 288 ? -25.629 65.063  106.561 1.00 116.06 ? 269 ARG A CB  1 
ATOM   793  C CG  . ARG A 1 288 ? -25.912 66.403  105.913 1.00 122.28 ? 269 ARG A CG  1 
ATOM   794  C CD  . ARG A 1 288 ? -24.753 67.314  106.231 1.00 130.33 ? 269 ARG A CD  1 
ATOM   795  N NE  . ARG A 1 288 ? -23.540 66.870  105.567 1.00 140.93 ? 269 ARG A NE  1 
ATOM   796  C CZ  . ARG A 1 288 ? -23.341 66.945  104.258 1.00 137.60 ? 269 ARG A CZ  1 
ATOM   797  N NH1 . ARG A 1 288 ? -24.286 67.438  103.478 1.00 134.45 ? 269 ARG A NH1 1 
ATOM   798  N NH2 . ARG A 1 288 ? -22.203 66.529  103.736 1.00 124.79 ? 269 ARG A NH2 1 
ATOM   799  N N   . ILE A 1 289 ? -27.810 63.229  108.114 1.00 117.28 ? 270 ILE A N   1 
ATOM   800  C CA  . ILE A 1 289 ? -28.895 63.293  109.119 1.00 123.27 ? 270 ILE A CA  1 
ATOM   801  C C   . ILE A 1 289 ? -28.671 64.573  109.912 1.00 129.18 ? 270 ILE A C   1 
ATOM   802  O O   . ILE A 1 289 ? -29.414 65.532  109.707 1.00 127.67 ? 270 ILE A O   1 
ATOM   803  C CB  . ILE A 1 289 ? -28.799 62.078  110.042 1.00 119.23 ? 270 ILE A CB  1 
ATOM   804  C CG1 . ILE A 1 289 ? -28.897 60.775  109.259 1.00 122.36 ? 270 ILE A CG1 1 
ATOM   805  C CG2 . ILE A 1 289 ? -29.867 62.153  111.108 1.00 122.47 ? 270 ILE A CG2 1 
ATOM   806  C CD1 . ILE A 1 289 ? -29.300 59.607  110.124 1.00 118.72 ? 270 ILE A CD1 1 
ATOM   807  N N   . LYS A 1 290 ? -27.658 64.562  110.778 1.00 128.37 ? 271 LYS A N   1 
ATOM   808  C CA  . LYS A 1 290 ? -27.343 65.741  111.620 1.00 133.70 ? 271 LYS A CA  1 
ATOM   809  C C   . LYS A 1 290 ? -26.719 66.817  110.736 1.00 133.22 ? 271 LYS A C   1 
ATOM   810  O O   . LYS A 1 290 ? -25.568 66.650  110.355 1.00 131.98 ? 271 LYS A O   1 
ATOM   811  C CB  . LYS A 1 290 ? -26.417 65.329  112.764 1.00 130.05 ? 271 LYS A CB  1 
ATOM   812  C CG  . LYS A 1 290 ? -25.009 64.929  112.365 1.00 128.27 ? 271 LYS A CG  1 
ATOM   813  C CD  . LYS A 1 290 ? -23.969 65.362  113.382 1.00 133.87 ? 271 LYS A CD  1 
ATOM   814  C CE  . LYS A 1 290 ? -22.762 64.449  113.476 1.00 129.02 ? 271 LYS A CE  1 
ATOM   815  N NZ  . LYS A 1 290 ? -21.632 64.908  112.635 1.00 118.30 ? 271 LYS A NZ  1 
ATOM   816  N N   . PRO A 1 291 ? -27.391 67.952  110.462 1.00 135.19 ? 272 PRO A N   1 
ATOM   817  C CA  . PRO A 1 291 ? -26.864 68.965  109.572 1.00 137.37 ? 272 PRO A CA  1 
ATOM   818  C C   . PRO A 1 291 ? -25.608 69.661  110.102 1.00 135.58 ? 272 PRO A C   1 
ATOM   819  O O   . PRO A 1 291 ? -25.357 69.668  111.275 1.00 121.30 ? 272 PRO A O   1 
ATOM   820  C CB  . PRO A 1 291 ? -28.025 69.945  109.382 1.00 130.29 ? 272 PRO A CB  1 
ATOM   821  C CG  . PRO A 1 291 ? -29.215 69.168  109.850 1.00 128.67 ? 272 PRO A CG  1 
ATOM   822  C CD  . PRO A 1 291 ? -28.668 68.369  111.009 1.00 133.66 ? 272 PRO A CD  1 
ATOM   823  N N   . LEU A 1 292 ? -24.885 70.276  109.176 1.00 135.19 ? 273 LEU A N   1 
ATOM   824  C CA  . LEU A 1 292 ? -23.593 70.944  109.441 1.00 133.32 ? 273 LEU A CA  1 
ATOM   825  C C   . LEU A 1 292 ? -23.685 71.946  110.581 1.00 138.69 ? 273 LEU A C   1 
ATOM   826  O O   . LEU A 1 292 ? -24.662 72.680  110.655 1.00 137.75 ? 273 LEU A O   1 
ATOM   827  C CB  . LEU A 1 292 ? -23.182 71.656  108.159 1.00 131.66 ? 273 LEU A CB  1 
ATOM   828  C CG  . LEU A 1 292 ? -22.514 70.751  107.136 1.00 135.95 ? 273 LEU A CG  1 
ATOM   829  C CD1 . LEU A 1 292 ? -22.440 71.427  105.779 1.00 127.39 ? 273 LEU A CD1 1 
ATOM   830  C CD2 . LEU A 1 292 ? -21.132 70.369  107.616 1.00 124.15 ? 273 LEU A CD2 1 
ATOM   831  N N   . PRO A 1 293 ? -22.647 72.037  111.427 1.00 141.37 ? 274 PRO A N   1 
ATOM   832  C CA  . PRO A 1 293 ? -22.616 73.001  112.498 1.00 134.91 ? 274 PRO A CA  1 
ATOM   833  C C   . PRO A 1 293 ? -22.526 74.343  111.779 1.00 129.48 ? 274 PRO A C   1 
ATOM   834  O O   . PRO A 1 293 ? -21.726 74.474  110.906 1.00 124.39 ? 274 PRO A O   1 
ATOM   835  C CB  . PRO A 1 293 ? -21.277 72.731  113.180 1.00 133.55 ? 274 PRO A CB  1 
ATOM   836  C CG  . PRO A 1 293 ? -20.957 71.315  112.800 1.00 133.83 ? 274 PRO A CG  1 
ATOM   837  C CD  . PRO A 1 293 ? -21.451 71.217  111.379 1.00 138.49 ? 274 PRO A CD  1 
ATOM   838  N N   . THR A 1 294 ? -23.351 75.290  112.203 1.00 134.78 ? 275 THR A N   1 
ATOM   839  C CA  . THR A 1 294 ? -23.437 76.634  111.589 1.00 132.49 ? 275 THR A CA  1 
ATOM   840  C C   . THR A 1 294 ? -22.107 77.371  111.720 1.00 128.48 ? 275 THR A C   1 
ATOM   841  O O   . THR A 1 294 ? -21.799 78.152  110.821 1.00 116.39 ? 275 THR A O   1 
ATOM   842  C CB  . THR A 1 294 ? -24.545 77.432  112.278 1.00 134.82 ? 275 THR A CB  1 
ATOM   843  O OG1 . THR A 1 294 ? -24.262 78.818  112.101 1.00 139.42 ? 275 THR A OG1 1 
ATOM   844  C CG2 . THR A 1 294 ? -24.641 77.120  113.752 1.00 124.27 ? 275 THR A CG2 1 
ATOM   845  N N   . LYS A 1 295 ? -21.403 77.196  112.835 1.00 125.65 ? 276 LYS A N   1 
ATOM   846  C CA  . LYS A 1 295 ? -20.113 77.903  112.988 1.00 119.78 ? 276 LYS A CA  1 
ATOM   847  C C   . LYS A 1 295 ? -19.001 76.920  112.675 1.00 112.28 ? 276 LYS A C   1 
ATOM   848  O O   . LYS A 1 295 ? -18.962 75.867  113.289 1.00 105.68 ? 276 LYS A O   1 
ATOM   849  C CB  . LYS A 1 295 ? -19.954 78.485  114.391 1.00 128.23 ? 276 LYS A CB  1 
ATOM   850  C CG  . LYS A 1 295 ? -19.243 79.832  114.456 1.00 124.46 ? 276 LYS A CG  1 
ATOM   851  C CD  . LYS A 1 295 ? -18.472 80.196  113.206 1.00 127.02 ? 276 LYS A CD  1 
ATOM   852  C CE  . LYS A 1 295 ? -17.377 81.209  113.474 1.00 120.52 ? 276 LYS A CE  1 
ATOM   853  N NZ  . LYS A 1 295 ? -16.666 81.618  112.240 1.00 116.09 ? 276 LYS A NZ  1 
ATOM   854  N N   . LYS A 1 296 ? -18.129 77.310  111.760 1.00 109.71 ? 277 LYS A N   1 
ATOM   855  C CA  . LYS A 1 296 ? -17.036 76.449  111.277 1.00 101.46 ? 277 LYS A CA  1 
ATOM   856  C C   . LYS A 1 296 ? -15.767 76.737  112.057 1.00 90.86  ? 277 LYS A C   1 
ATOM   857  O O   . LYS A 1 296 ? -15.698 77.760  112.683 1.00 97.59  ? 277 LYS A O   1 
ATOM   858  C CB  . LYS A 1 296 ? -16.862 76.770  109.799 1.00 95.90  ? 277 LYS A CB  1 
ATOM   859  C CG  . LYS A 1 296 ? -18.160 76.716  109.018 1.00 91.49  ? 277 LYS A CG  1 
ATOM   860  C CD  . LYS A 1 296 ? -18.049 77.278  107.643 1.00 96.99  ? 277 LYS A CD  1 
ATOM   861  C CE  . LYS A 1 296 ? -19.070 76.681  106.703 1.00 116.16 ? 277 LYS A CE  1 
ATOM   862  N NZ  . LYS A 1 296 ? -18.782 77.013  105.288 1.00 111.17 ? 277 LYS A NZ  1 
ATOM   863  N N   . THR A 1 297 ? -14.805 75.836  111.987 1.00 80.51  ? 278 THR A N   1 
ATOM   864  C CA  . THR A 1 297 ? -13.547 76.045  112.713 1.00 80.87  ? 278 THR A CA  1 
ATOM   865  C C   . THR A 1 297 ? -12.405 75.902  111.729 1.00 84.45  ? 278 THR A C   1 
ATOM   866  O O   . THR A 1 297 ? -12.374 74.922  111.060 1.00 84.00  ? 278 THR A O   1 
ATOM   867  C CB  . THR A 1 297 ? -13.362 74.905  113.703 1.00 80.85  ? 278 THR A CB  1 
ATOM   868  O OG1 . THR A 1 297 ? -14.601 74.772  114.382 1.00 88.06  ? 278 THR A OG1 1 
ATOM   869  C CG2 . THR A 1 297 ? -12.295 75.188  114.725 1.00 88.41  ? 278 THR A CG2 1 
ATOM   870  N N   . GLY A 1 298 ? -11.571 76.917  111.571 1.00 90.36  ? 279 GLY A N   1 
ATOM   871  C CA  . GLY A 1 298 ? -10.381 76.821  110.709 1.00 83.77  ? 279 GLY A CA  1 
ATOM   872  C C   . GLY A 1 298 ? -10.640 77.205  109.278 1.00 77.97  ? 279 GLY A C   1 
ATOM   873  O O   . GLY A 1 298 ? -11.707 76.924  108.787 1.00 81.71  ? 279 GLY A O   1 
ATOM   874  N N   . LYS A 1 299 ? -9.646  77.756  108.598 1.00 72.38  ? 280 LYS A N   1 
ATOM   875  C CA  . LYS A 1 299 ? -9.884  78.109  107.186 1.00 72.18  ? 280 LYS A CA  1 
ATOM   876  C C   . LYS A 1 299 ? -8.874  77.382  106.319 1.00 74.66  ? 280 LYS A C   1 
ATOM   877  O O   . LYS A 1 299 ? -7.700  77.580  106.510 1.00 75.07  ? 280 LYS A O   1 
ATOM   878  C CB  . LYS A 1 299 ? -9.726  79.607  106.974 1.00 74.00  ? 280 LYS A CB  1 
ATOM   879  C CG  . LYS A 1 299 ? -9.855  80.053  105.532 1.00 84.22  ? 280 LYS A CG  1 
ATOM   880  C CD  . LYS A 1 299 ? -11.088 79.513  104.849 1.00 91.23  ? 280 LYS A CD  1 
ATOM   881  C CE  . LYS A 1 299 ? -11.398 80.216  103.546 1.00 82.61  ? 280 LYS A CE  1 
ATOM   882  N NZ  . LYS A 1 299 ? -12.856 80.296  103.307 1.00 87.45  ? 280 LYS A NZ  1 
ATOM   883  N N   . VAL A 1 300 ? -9.358  76.632  105.345 1.00 74.10  ? 281 VAL A N   1 
ATOM   884  C CA  . VAL A 1 300 ? -8.440  75.875  104.465 1.00 76.63  ? 281 VAL A CA  1 
ATOM   885  C C   . VAL A 1 300 ? -8.694  76.247  103.025 1.00 73.27  ? 281 VAL A C   1 
ATOM   886  O O   . VAL A 1 300 ? -9.815  76.173  102.589 1.00 76.26  ? 281 VAL A O   1 
ATOM   887  C CB  . VAL A 1 300 ? -8.666  74.371  104.594 1.00 75.69  ? 281 VAL A CB  1 
ATOM   888  C CG1 . VAL A 1 300 ? -7.502  73.612  104.020 1.00 63.08  ? 281 VAL A CG1 1 
ATOM   889  C CG2 . VAL A 1 300 ? -8.894  73.985  106.030 1.00 82.31  ? 281 VAL A CG2 1 
ATOM   890  N N   . ILE A 1 301 ? -7.633  76.655  102.368 1.00 68.49  ? 282 ILE A N   1 
ATOM   891  C CA  . ILE A 1 301 ? -7.609  76.900  100.928 1.00 68.90  ? 282 ILE A CA  1 
ATOM   892  C C   . ILE A 1 301 ? -7.127  75.642  100.210 1.00 72.37  ? 282 ILE A C   1 
ATOM   893  O O   . ILE A 1 301 ? -6.029  75.138  100.498 1.00 66.74  ? 282 ILE A O   1 
ATOM   894  C CB  . ILE A 1 301 ? -6.688  78.079  100.591 1.00 68.92  ? 282 ILE A CB  1 
ATOM   895  C CG1 . ILE A 1 301 ? -7.334  79.388  101.008 1.00 69.56  ? 282 ILE A CG1 1 
ATOM   896  C CG2 . ILE A 1 301 ? -6.282  78.045  99.130  1.00 68.20  ? 282 ILE A CG2 1 
ATOM   897  C CD1 . ILE A 1 301 ? -8.651  79.625  100.315 1.00 74.33  ? 282 ILE A CD1 1 
ATOM   898  N N   . ILE A 1 302 ? -7.930  75.146  99.266  1.00 69.82  ? 283 ILE A N   1 
ATOM   899  C CA  . ILE A 1 302 ? -7.557  74.029  98.404  1.00 66.54  ? 283 ILE A CA  1 
ATOM   900  C C   . ILE A 1 302 ? -7.202  74.549  97.015  1.00 67.57  ? 283 ILE A C   1 
ATOM   901  O O   . ILE A 1 302 ? -7.996  75.266  96.391  1.00 70.79  ? 283 ILE A O   1 
ATOM   902  C CB  . ILE A 1 302 ? -8.682  72.999  98.304  1.00 68.51  ? 283 ILE A CB  1 
ATOM   903  C CG1 . ILE A 1 302 ? -8.884  72.333  99.659  1.00 72.39  ? 283 ILE A CG1 1 
ATOM   904  C CG2 . ILE A 1 302 ? -8.367  72.000  97.216  1.00 69.38  ? 283 ILE A CG2 1 
ATOM   905  C CD1 . ILE A 1 302 ? -10.106 71.443  99.705  1.00 73.09  ? 283 ILE A CD1 1 
ATOM   906  N N   . ILE A 1 303 ? -6.027  74.179  96.518  1.00 59.55  ? 284 ILE A N   1 
ATOM   907  C CA  . ILE A 1 303 ? -5.633  74.584  95.178  1.00 60.88  ? 284 ILE A CA  1 
ATOM   908  C C   . ILE A 1 303 ? -6.077  73.492  94.207  1.00 63.48  ? 284 ILE A C   1 
ATOM   909  O O   . ILE A 1 303 ? -5.576  72.363  94.236  1.00 58.83  ? 284 ILE A O   1 
ATOM   910  C CB  . ILE A 1 303 ? -4.134  74.865  95.084  1.00 60.94  ? 284 ILE A CB  1 
ATOM   911  C CG1 . ILE A 1 303 ? -3.811  76.114  95.902  1.00 59.37  ? 284 ILE A CG1 1 
ATOM   912  C CG2 . ILE A 1 303 ? -3.744  75.124  93.635  1.00 57.29  ? 284 ILE A CG2 1 
ATOM   913  C CD1 . ILE A 1 303 ? -2.341  76.303  96.251  1.00 48.28  ? 284 ILE A CD1 1 
ATOM   914  N N   . GLY A 1 304 ? -7.052  73.829  93.367  1.00 64.98  ? 285 GLY A N   1 
ATOM   915  C CA  . GLY A 1 304 ? -7.475  72.979  92.276  1.00 65.02  ? 285 GLY A CA  1 
ATOM   916  C C   . GLY A 1 304 ? -8.726  72.226  92.640  1.00 68.95  ? 285 GLY A C   1 
ATOM   917  O O   . GLY A 1 304 ? -8.825  71.697  93.746  1.00 67.29  ? 285 GLY A O   1 
ATOM   918  N N   . SER A 1 305 ? -9.657  72.287  91.711  1.00 71.49  ? 286 SER A N   1 
ATOM   919  C CA  . SER A 1 305 ? -10.981 71.673  91.847  1.00 70.55  ? 286 SER A CA  1 
ATOM   920  C C   . SER A 1 305 ? -10.975 70.365  91.090  1.00 75.67  ? 286 SER A C   1 
ATOM   921  O O   . SER A 1 305 ? -11.968 70.059  90.502  1.00 75.78  ? 286 SER A O   1 
ATOM   922  C CB  . SER A 1 305 ? -12.002 72.603  91.327  1.00 76.21  ? 286 SER A CB  1 
ATOM   923  O OG  . SER A 1 305 ? -13.013 71.919  90.631  1.00 83.44  ? 286 SER A OG  1 
ATOM   924  N N   . GLY A 1 306 ? -9.885  69.616  91.182  1.00 74.70  ? 287 GLY A N   1 
ATOM   925  C CA  . GLY A 1 306 ? -9.801  68.276  90.588  1.00 70.42  ? 287 GLY A CA  1 
ATOM   926  C C   . GLY A 1 306 ? -10.432 67.264  91.510  1.00 67.84  ? 287 GLY A C   1 
ATOM   927  O O   . GLY A 1 306 ? -10.737 67.601  92.623  1.00 69.72  ? 287 GLY A O   1 
ATOM   928  N N   . VAL A 1 307 ? -10.495 66.005  91.128  1.00 69.06  ? 288 VAL A N   1 
ATOM   929  C CA  . VAL A 1 307 ? -11.187 65.024  92.005  1.00 65.50  ? 288 VAL A CA  1 
ATOM   930  C C   . VAL A 1 307 ? -10.514 64.919  93.364  1.00 67.56  ? 288 VAL A C   1 
ATOM   931  O O   . VAL A 1 307 ? -11.218 64.860  94.326  1.00 67.62  ? 288 VAL A O   1 
ATOM   932  C CB  . VAL A 1 307 ? -11.327 63.668  91.322  1.00 65.66  ? 288 VAL A CB  1 
ATOM   933  C CG1 . VAL A 1 307 ? -12.130 62.724  92.178  1.00 57.90  ? 288 VAL A CG1 1 
ATOM   934  C CG2 . VAL A 1 307 ? -11.992 63.849  89.985  1.00 63.69  ? 288 VAL A CG2 1 
ATOM   935  N N   . SER A 1 308 ? -9.197  64.997  93.430  1.00 64.62  ? 289 SER A N   1 
ATOM   936  C CA  . SER A 1 308 ? -8.537  64.995  94.745  1.00 67.67  ? 289 SER A CA  1 
ATOM   937  C C   . SER A 1 308 ? -9.024  66.232  95.478  1.00 70.87  ? 289 SER A C   1 
ATOM   938  O O   . SER A 1 308 ? -9.436  66.122  96.599  1.00 63.89  ? 289 SER A O   1 
ATOM   939  C CB  . SER A 1 308 ? -7.096  65.088  94.553  1.00 64.53  ? 289 SER A CB  1 
ATOM   940  O OG  . SER A 1 308 ? -6.855  66.181  93.715  1.00 67.48  ? 289 SER A OG  1 
ATOM   941  N N   . GLY A 1 309 ? -8.989  67.372  94.815  1.00 71.85  ? 290 GLY A N   1 
ATOM   942  C CA  . GLY A 1 309 ? -9.432  68.617  95.452  1.00 68.93  ? 290 GLY A CA  1 
ATOM   943  C C   . GLY A 1 309 ? -10.825 68.523  96.007  1.00 67.68  ? 290 GLY A C   1 
ATOM   944  O O   . GLY A 1 309 ? -10.988 68.665  97.179  1.00 70.98  ? 290 GLY A O   1 
ATOM   945  N N   . LEU A 1 310 ? -11.803 68.216  95.182  1.00 69.34  ? 291 LEU A N   1 
ATOM   946  C CA  . LEU A 1 310 ? -13.195 68.194  95.670  1.00 66.27  ? 291 LEU A CA  1 
ATOM   947  C C   . LEU A 1 310 ? -13.378 67.158  96.758  1.00 66.14  ? 291 LEU A C   1 
ATOM   948  O O   . LEU A 1 310 ? -14.123 67.407  97.653  1.00 73.49  ? 291 LEU A O   1 
ATOM   949  C CB  . LEU A 1 310 ? -14.096 67.879  94.492  1.00 69.46  ? 291 LEU A CB  1 
ATOM   950  C CG  . LEU A 1 310 ? -13.905 68.801  93.309  1.00 72.42  ? 291 LEU A CG  1 
ATOM   951  C CD1 . LEU A 1 310 ? -13.873 67.994  92.051  1.00 69.57  ? 291 LEU A CD1 1 
ATOM   952  C CD2 . LEU A 1 310 ? -15.043 69.775  93.245  1.00 78.25  ? 291 LEU A CD2 1 
ATOM   953  N N   . ALA A 1 311 ? -12.742 66.016  96.647  1.00 64.27  ? 292 ALA A N   1 
ATOM   954  C CA  . ALA A 1 311 ? -12.888 64.998  97.693  1.00 70.85  ? 292 ALA A CA  1 
ATOM   955  C C   . ALA A 1 311 ? -12.441 65.588  99.018  1.00 72.18  ? 292 ALA A C   1 
ATOM   956  O O   . ALA A 1 311 ? -13.123 65.423  99.983  1.00 75.95  ? 292 ALA A O   1 
ATOM   957  C CB  . ALA A 1 311 ? -12.040 63.829  97.324  1.00 70.95  ? 292 ALA A CB  1 
ATOM   958  N N   . ALA A 1 312 ? -11.296 66.229  99.051  1.00 66.61  ? 293 ALA A N   1 
ATOM   959  C CA  . ALA A 1 312 ? -10.867 66.817  100.321 1.00 68.01  ? 293 ALA A CA  1 
ATOM   960  C C   . ALA A 1 312 ? -11.888 67.861  100.740 1.00 73.36  ? 293 ALA A C   1 
ATOM   961  O O   . ALA A 1 312 ? -12.324 67.818  101.862 1.00 73.43  ? 293 ALA A O   1 
ATOM   962  C CB  . ALA A 1 312 ? -9.531  67.444  100.114 1.00 63.56  ? 293 ALA A CB  1 
ATOM   963  N N   . ALA A 1 313 ? -12.233 68.756  99.830  1.00 69.34  ? 294 ALA A N   1 
ATOM   964  C CA  . ALA A 1 313 ? -13.187 69.842  100.105 1.00 68.85  ? 294 ALA A CA  1 
ATOM   965  C C   . ALA A 1 313 ? -14.443 69.283  100.738 1.00 72.44  ? 294 ALA A C   1 
ATOM   966  O O   . ALA A 1 313 ? -14.712 69.696  101.827 1.00 78.10  ? 294 ALA A O   1 
ATOM   967  C CB  . ALA A 1 313 ? -13.513 70.559  98.841  1.00 68.32  ? 294 ALA A CB  1 
ATOM   968  N N   . ARG A 1 314 ? -15.166 68.415  100.046 1.00 69.28  ? 295 ARG A N   1 
ATOM   969  C CA  . ARG A 1 314 ? -16.370 67.803  100.615 1.00 73.62  ? 295 ARG A CA  1 
ATOM   970  C C   . ARG A 1 314 ? -16.104 67.271  102.018 1.00 75.46  ? 295 ARG A C   1 
ATOM   971  O O   . ARG A 1 314 ? -16.907 67.487  102.934 1.00 72.82  ? 295 ARG A O   1 
ATOM   972  C CB  . ARG A 1 314 ? -16.888 66.648  99.759  1.00 72.60  ? 295 ARG A CB  1 
ATOM   973  C CG  . ARG A 1 314 ? -17.249 66.980  98.355  1.00 79.93  ? 295 ARG A CG  1 
ATOM   974  C CD  . ARG A 1 314 ? -18.707 67.236  98.191  1.00 79.51  ? 295 ARG A CD  1 
ATOM   975  N NE  . ARG A 1 314 ? -19.560 66.341  98.944  1.00 74.38  ? 295 ARG A NE  1 
ATOM   976  C CZ  . ARG A 1 314 ? -20.882 66.376  98.831  1.00 84.25  ? 295 ARG A CZ  1 
ATOM   977  N NH1 . ARG A 1 314 ? -21.639 65.571  99.575  1.00 91.34  ? 295 ARG A NH1 1 
ATOM   978  N NH2 . ARG A 1 314 ? -21.443 67.247  97.984  1.00 78.36  ? 295 ARG A NH2 1 
ATOM   979  N N   . GLN A 1 315 ? -14.981 66.571  102.199 1.00 68.74  ? 296 GLN A N   1 
ATOM   980  C CA  . GLN A 1 315 ? -14.678 65.987  103.498 1.00 74.17  ? 296 GLN A CA  1 
ATOM   981  C C   . GLN A 1 315 ? -14.498 67.062  104.559 1.00 78.99  ? 296 GLN A C   1 
ATOM   982  O O   . GLN A 1 315 ? -14.999 66.929  105.680 1.00 78.67  ? 296 GLN A O   1 
ATOM   983  C CB  . GLN A 1 315 ? -13.408 65.146  103.413 1.00 70.81  ? 296 GLN A CB  1 
ATOM   984  C CG  . GLN A 1 315 ? -13.563 63.730  102.965 1.00 70.92  ? 296 GLN A CG  1 
ATOM   985  C CD  . GLN A 1 315 ? -14.656 63.000  103.647 1.00 76.20  ? 296 GLN A CD  1 
ATOM   986  O OE1 . GLN A 1 315 ? -15.838 63.129  103.290 1.00 82.86  ? 296 GLN A OE1 1 
ATOM   987  N NE2 . GLN A 1 315 ? -14.281 62.186  104.631 1.00 79.28  ? 296 GLN A NE2 1 
ATOM   988  N N   . LEU A 1 316 ? -13.752 68.121  104.235 1.00 79.77  ? 297 LEU A N   1 
ATOM   989  C CA  . LEU A 1 316 ? -13.446 69.146  105.227 1.00 74.97  ? 297 LEU A CA  1 
ATOM   990  C C   . LEU A 1 316 ? -14.700 69.912  105.617 1.00 76.85  ? 297 LEU A C   1 
ATOM   991  O O   . LEU A 1 316 ? -15.053 69.970  106.800 1.00 80.62  ? 297 LEU A O   1 
ATOM   992  C CB  . LEU A 1 316 ? -12.368 70.080  104.697 1.00 69.47  ? 297 LEU A CB  1 
ATOM   993  C CG  . LEU A 1 316 ? -11.033 69.367  104.696 1.00 65.33  ? 297 LEU A CG  1 
ATOM   994  C CD1 . LEU A 1 316 ? -9.968  70.240  104.105 1.00 67.99  ? 297 LEU A CD1 1 
ATOM   995  C CD2 . LEU A 1 316 ? -10.699 68.968  106.115 1.00 65.53  ? 297 LEU A CD2 1 
ATOM   996  N N   . GLN A 1 317 ? -15.398 70.488  104.638 1.00 69.19  ? 298 GLN A N   1 
ATOM   997  C CA  . GLN A 1 317 ? -16.733 70.996  104.905 1.00 70.97  ? 298 GLN A CA  1 
ATOM   998  C C   . GLN A 1 317 ? -17.552 70.016  105.752 1.00 81.12  ? 298 GLN A C   1 
ATOM   999  O O   . GLN A 1 317 ? -18.043 70.371  106.827 1.00 85.18  ? 298 GLN A O   1 
ATOM   1000 C CB  . GLN A 1 317 ? -17.440 71.298  103.600 1.00 67.25  ? 298 GLN A CB  1 
ATOM   1001 C CG  . GLN A 1 317 ? -18.765 71.901  103.843 1.00 78.39  ? 298 GLN A CG  1 
ATOM   1002 C CD  . GLN A 1 317 ? -19.433 72.368  102.587 1.00 88.73  ? 298 GLN A CD  1 
ATOM   1003 O OE1 . GLN A 1 317 ? -20.037 71.568  101.873 1.00 93.77  ? 298 GLN A OE1 1 
ATOM   1004 N NE2 . GLN A 1 317 ? -19.333 73.676  102.298 1.00 86.88  ? 298 GLN A NE2 1 
ATOM   1005 N N   . SER A 1 318 ? -17.689 68.767  105.301 1.00 82.86  ? 299 SER A N   1 
ATOM   1006 C CA  . SER A 1 318 ? -18.298 67.694  106.094 1.00 82.18  ? 299 SER A CA  1 
ATOM   1007 C C   . SER A 1 318 ? -17.854 67.711  107.556 1.00 80.37  ? 299 SER A C   1 
ATOM   1008 O O   . SER A 1 318 ? -18.622 67.331  108.440 1.00 83.85  ? 299 SER A O   1 
ATOM   1009 C CB  . SER A 1 318 ? -17.965 66.327  105.450 1.00 89.15  ? 299 SER A CB  1 
ATOM   1010 O OG  . SER A 1 318 ? -18.358 65.170  106.183 1.00 88.80  ? 299 SER A OG  1 
ATOM   1011 N N   . PHE A 1 319 ? -16.624 68.136  107.830 1.00 78.83  ? 300 PHE A N   1 
ATOM   1012 C CA  . PHE A 1 319 ? -16.076 68.086  109.183 1.00 80.25  ? 300 PHE A CA  1 
ATOM   1013 C C   . PHE A 1 319 ? -16.248 69.390  109.936 1.00 86.00  ? 300 PHE A C   1 
ATOM   1014 O O   . PHE A 1 319 ? -15.777 69.501  111.073 1.00 87.08  ? 300 PHE A O   1 
ATOM   1015 C CB  . PHE A 1 319 ? -14.583 67.778  109.172 1.00 83.10  ? 300 PHE A CB  1 
ATOM   1016 C CG  . PHE A 1 319 ? -14.234 66.444  108.629 1.00 82.38  ? 300 PHE A CG  1 
ATOM   1017 C CD1 . PHE A 1 319 ? -12.906 66.090  108.476 1.00 81.20  ? 300 PHE A CD1 1 
ATOM   1018 C CD2 . PHE A 1 319 ? -15.216 65.538  108.281 1.00 87.63  ? 300 PHE A CD2 1 
ATOM   1019 C CE1 . PHE A 1 319 ? -12.556 64.866  107.975 1.00 84.00  ? 300 PHE A CE1 1 
ATOM   1020 C CE2 . PHE A 1 319 ? -14.881 64.292  107.763 1.00 90.30  ? 300 PHE A CE2 1 
ATOM   1021 C CZ  . PHE A 1 319 ? -13.545 63.951  107.621 1.00 88.89  ? 300 PHE A CZ  1 
ATOM   1022 N N   . GLY A 1 320 ? -16.857 70.392  109.316 1.00 87.34  ? 301 GLY A N   1 
ATOM   1023 C CA  . GLY A 1 320 ? -17.089 71.648  109.990 1.00 84.49  ? 301 GLY A CA  1 
ATOM   1024 C C   . GLY A 1 320 ? -15.948 72.616  109.790 1.00 83.77  ? 301 GLY A C   1 
ATOM   1025 O O   . GLY A 1 320 ? -15.647 73.426  110.667 1.00 94.20  ? 301 GLY A O   1 
ATOM   1026 N N   . MET A 1 321 ? -15.305 72.559  108.642 1.00 78.85  ? 302 MET A N   1 
ATOM   1027 C CA  . MET A 1 321 ? -14.232 73.487  108.371 1.00 74.98  ? 302 MET A CA  1 
ATOM   1028 C C   . MET A 1 321 ? -14.659 74.446  107.279 1.00 75.89  ? 302 MET A C   1 
ATOM   1029 O O   . MET A 1 321 ? -15.614 74.187  106.537 1.00 80.24  ? 302 MET A O   1 
ATOM   1030 C CB  . MET A 1 321 ? -12.970 72.745  107.977 1.00 75.33  ? 302 MET A CB  1 
ATOM   1031 C CG  . MET A 1 321 ? -12.159 72.394  109.169 1.00 74.26  ? 302 MET A CG  1 
ATOM   1032 S SD  . MET A 1 321 ? -10.566 71.791  108.685 1.00 77.53  ? 302 MET A SD  1 
ATOM   1033 C CE  . MET A 1 321 ? -9.501  72.578  109.879 1.00 80.13  ? 302 MET A CE  1 
ATOM   1034 N N   . ASP A 1 322 ? -13.965 75.581  107.213 1.00 73.55  ? 303 ASP A N   1 
ATOM   1035 C CA  . ASP A 1 322 ? -14.227 76.580  106.182 1.00 79.45  ? 303 ASP A CA  1 
ATOM   1036 C C   . ASP A 1 322 ? -13.309 76.295  105.000 1.00 85.01  ? 303 ASP A C   1 
ATOM   1037 O O   . ASP A 1 322 ? -12.095 76.536  105.064 1.00 80.95  ? 303 ASP A O   1 
ATOM   1038 C CB  . ASP A 1 322 ? -14.012 77.994  106.699 1.00 82.26  ? 303 ASP A CB  1 
ATOM   1039 C CG  . ASP A 1 322 ? -14.524 79.051  105.734 1.00 96.40  ? 303 ASP A CG  1 
ATOM   1040 O OD1 . ASP A 1 322 ? -14.615 80.243  106.131 1.00 100.34 ? 303 ASP A OD1 1 
ATOM   1041 O OD2 . ASP A 1 322 ? -14.843 78.689  104.572 1.00 104.52 ? 303 ASP A OD2 1 
ATOM   1042 N N   . VAL A 1 323 ? -13.893 75.801  103.920 1.00 83.34  ? 304 VAL A N   1 
ATOM   1043 C CA  . VAL A 1 323 ? -13.139 75.342  102.769 1.00 78.89  ? 304 VAL A CA  1 
ATOM   1044 C C   . VAL A 1 323 ? -13.385 76.291  101.617 1.00 77.91  ? 304 VAL A C   1 
ATOM   1045 O O   . VAL A 1 323 ? -14.515 76.733  101.393 1.00 80.42  ? 304 VAL A O   1 
ATOM   1046 C CB  . VAL A 1 323 ? -13.548 73.916  102.376 1.00 76.73  ? 304 VAL A CB  1 
ATOM   1047 C CG1 . VAL A 1 323 ? -12.586 73.383  101.375 1.00 77.59  ? 304 VAL A CG1 1 
ATOM   1048 C CG2 . VAL A 1 323 ? -13.603 73.031  103.601 1.00 77.91  ? 304 VAL A CG2 1 
ATOM   1049 N N   . THR A 1 324 ? -12.327 76.594  100.882 1.00 78.59  ? 305 THR A N   1 
ATOM   1050 C CA  . THR A 1 324 ? -12.471 77.284  99.612  1.00 79.62  ? 305 THR A CA  1 
ATOM   1051 C C   . THR A 1 324 ? -11.467 76.740  98.603  1.00 78.57  ? 305 THR A C   1 
ATOM   1052 O O   . THR A 1 324 ? -10.275 76.597  98.910  1.00 72.71  ? 305 THR A O   1 
ATOM   1053 C CB  . THR A 1 324 ? -12.322 78.790  99.798  1.00 75.08  ? 305 THR A CB  1 
ATOM   1054 O OG1 . THR A 1 324 ? -13.536 79.282  100.366 1.00 85.88  ? 305 THR A OG1 1 
ATOM   1055 C CG2 . THR A 1 324 ? -12.080 79.482  98.483  1.00 77.03  ? 305 THR A CG2 1 
ATOM   1056 N N   . LEU A 1 325 ? -11.964 76.420  97.406  1.00 76.90  ? 306 LEU A N   1 
ATOM   1057 C CA  . LEU A 1 325 ? -11.135 75.875  96.351  1.00 73.02  ? 306 LEU A CA  1 
ATOM   1058 C C   . LEU A 1 325 ? -10.874 76.970  95.334  1.00 66.91  ? 306 LEU A C   1 
ATOM   1059 O O   . LEU A 1 325 ? -11.793 77.701  94.958  1.00 67.69  ? 306 LEU A O   1 
ATOM   1060 C CB  . LEU A 1 325 ? -11.795 74.696  95.627  1.00 71.42  ? 306 LEU A CB  1 
ATOM   1061 C CG  . LEU A 1 325 ? -12.101 73.440  96.412  1.00 67.86  ? 306 LEU A CG  1 
ATOM   1062 C CD1 . LEU A 1 325 ? -13.498 73.601  96.970  1.00 71.58  ? 306 LEU A CD1 1 
ATOM   1063 C CD2 . LEU A 1 325 ? -11.925 72.176  95.655  1.00 74.00  ? 306 LEU A CD2 1 
ATOM   1064 N N   . LEU A 1 326 ? -9.629  77.039  94.901  1.00 61.32  ? 307 LEU A N   1 
ATOM   1065 C CA  . LEU A 1 326 ? -9.203  77.993  93.871  1.00 67.38  ? 307 LEU A CA  1 
ATOM   1066 C C   . LEU A 1 326 ? -8.986  77.178  92.619  1.00 70.06  ? 307 LEU A C   1 
ATOM   1067 O O   . LEU A 1 326 ? -8.248  76.234  92.665  1.00 68.81  ? 307 LEU A O   1 
ATOM   1068 C CB  . LEU A 1 326 ? -7.905  78.641  94.313  1.00 69.97  ? 307 LEU A CB  1 
ATOM   1069 C CG  . LEU A 1 326 ? -8.008  79.392  95.625  1.00 71.01  ? 307 LEU A CG  1 
ATOM   1070 C CD1 . LEU A 1 326 ? -6.749  80.170  95.871  1.00 66.80  ? 307 LEU A CD1 1 
ATOM   1071 C CD2 . LEU A 1 326 ? -9.179  80.323  95.583  1.00 75.39  ? 307 LEU A CD2 1 
ATOM   1072 N N   . GLU A 1 327 ? -9.599  77.621  91.543  1.00 70.73  ? 308 GLU A N   1 
ATOM   1073 C CA  . GLU A 1 327 ? -9.627  76.919  90.258  1.00 73.75  ? 308 GLU A CA  1 
ATOM   1074 C C   . GLU A 1 327 ? -9.017  77.784  89.177  1.00 73.17  ? 308 GLU A C   1 
ATOM   1075 O O   . GLU A 1 327 ? -9.427  78.908  89.069  1.00 71.95  ? 308 GLU A O   1 
ATOM   1076 C CB  . GLU A 1 327 ? -11.096 76.960  89.912  1.00 72.15  ? 308 GLU A CB  1 
ATOM   1077 C CG  . GLU A 1 327 ? -11.522 75.915  88.940  1.00 75.83  ? 308 GLU A CG  1 
ATOM   1078 C CD  . GLU A 1 327 ? -10.415 74.936  88.725  1.00 78.50  ? 308 GLU A CD  1 
ATOM   1079 O OE1 . GLU A 1 327 ? -9.531  75.182  87.930  1.00 75.08  ? 308 GLU A OE1 1 
ATOM   1080 O OE2 . GLU A 1 327 ? -10.427 73.897  89.354  1.00 78.37  ? 308 GLU A OE2 1 
ATOM   1081 N N   . ALA A 1 328 ? -8.096  77.256  88.390  1.00 71.73  ? 309 ALA A N   1 
ATOM   1082 C CA  . ALA A 1 328 ? -7.539  78.074  87.302  1.00 71.03  ? 309 ALA A CA  1 
ATOM   1083 C C   . ALA A 1 328 ? -8.504  77.990  86.140  1.00 77.59  ? 309 ALA A C   1 
ATOM   1084 O O   . ALA A 1 328 ? -8.669  78.954  85.428  1.00 75.30  ? 309 ALA A O   1 
ATOM   1085 C CB  . ALA A 1 328 ? -6.219  77.527  86.895  1.00 64.05  ? 309 ALA A CB  1 
ATOM   1086 N N   . ARG A 1 329 ? -9.132  76.839  85.996  1.00 80.69  ? 310 ARG A N   1 
ATOM   1087 C CA  . ARG A 1 329 ? -10.029 76.635  84.873  1.00 81.10  ? 310 ARG A CA  1 
ATOM   1088 C C   . ARG A 1 329 ? -11.375 77.302  85.126  1.00 82.63  ? 310 ARG A C   1 
ATOM   1089 O O   . ARG A 1 329 ? -11.716 77.674  86.254  1.00 82.75  ? 310 ARG A O   1 
ATOM   1090 C CB  . ARG A 1 329 ? -10.271 75.150  84.630  1.00 77.87  ? 310 ARG A CB  1 
ATOM   1091 C CG  . ARG A 1 329 ? -9.078  74.369  84.124  1.00 78.18  ? 310 ARG A CG  1 
ATOM   1092 C CD  . ARG A 1 329 ? -9.435  72.873  84.111  1.00 78.01  ? 310 ARG A CD  1 
ATOM   1093 N NE  . ARG A 1 329 ? -8.249  72.053  83.951  1.00 75.11  ? 310 ARG A NE  1 
ATOM   1094 C CZ  . ARG A 1 329 ? -7.594  71.929  82.807  1.00 73.38  ? 310 ARG A CZ  1 
ATOM   1095 N NH1 . ARG A 1 329 ? -8.016  72.573  81.724  1.00 81.25  ? 310 ARG A NH1 1 
ATOM   1096 N NH2 . ARG A 1 329 ? -6.516  71.170  82.749  1.00 71.42  ? 310 ARG A NH2 1 
ATOM   1097 N N   . ASP A 1 330 ? -12.221 77.241  84.101  1.00 84.50  ? 311 ASP A N   1 
ATOM   1098 C CA  . ASP A 1 330 ? -13.608 77.743  84.198  1.00 78.16  ? 311 ASP A CA  1 
ATOM   1099 C C   . ASP A 1 330 ? -14.520 76.562  84.465  1.00 76.08  ? 311 ASP A C   1 
ATOM   1100 O O   . ASP A 1 330 ? -15.696 76.690  84.231  1.00 74.69  ? 311 ASP A O   1 
ATOM   1101 C CB  . ASP A 1 330 ? -14.109 78.312  82.882  1.00 75.95  ? 311 ASP A CB  1 
ATOM   1102 C CG  . ASP A 1 330 ? -13.387 77.736  81.691  1.00 94.47  ? 311 ASP A CG  1 
ATOM   1103 O OD1 . ASP A 1 330 ? -12.323 77.165  81.895  1.00 91.73  ? 311 ASP A OD1 1 
ATOM   1104 O OD2 . ASP A 1 330 ? -13.898 77.875  80.583  1.00 95.60  ? 311 ASP A OD2 1 
ATOM   1105 N N   . ARG A 1 331 ? -13.972 75.443  84.898  1.00 68.35  ? 312 ARG A N   1 
ATOM   1106 C CA  . ARG A 1 331 ? -14.842 74.285  85.162  1.00 72.44  ? 312 ARG A CA  1 
ATOM   1107 C C   . ARG A 1 331 ? -14.169 73.379  86.174  1.00 76.85  ? 312 ARG A C   1 
ATOM   1108 O O   . ARG A 1 331 ? -12.988 73.470  86.327  1.00 83.25  ? 312 ARG A O   1 
ATOM   1109 C CB  . ARG A 1 331 ? -15.013 73.499  83.869  1.00 77.98  ? 312 ARG A CB  1 
ATOM   1110 C CG  . ARG A 1 331 ? -13.781 72.705  83.484  1.00 78.02  ? 312 ARG A CG  1 
ATOM   1111 C CD  . ARG A 1 331 ? -13.697 72.298  82.038  1.00 77.39  ? 312 ARG A CD  1 
ATOM   1112 N NE  . ARG A 1 331 ? -12.445 71.606  81.856  1.00 80.61  ? 312 ARG A NE  1 
ATOM   1113 C CZ  . ARG A 1 331 ? -12.087 70.577  82.581  1.00 77.22  ? 312 ARG A CZ  1 
ATOM   1114 N NH1 . ARG A 1 331 ? -12.907 70.124  83.501  1.00 74.45  ? 312 ARG A NH1 1 
ATOM   1115 N NH2 . ARG A 1 331 ? -10.932 69.986  82.383  1.00 72.08  ? 312 ARG A NH2 1 
ATOM   1116 N N   . VAL A 1 332 ? -14.929 72.527  86.834  1.00 67.09  ? 313 VAL A N   1 
ATOM   1117 C CA  . VAL A 1 332 ? -14.326 71.589  87.810  1.00 72.23  ? 313 VAL A CA  1 
ATOM   1118 C C   . VAL A 1 332 ? -13.925 70.302  87.105  1.00 78.81  ? 313 VAL A C   1 
ATOM   1119 O O   . VAL A 1 332 ? -14.179 70.172  85.930  1.00 84.10  ? 313 VAL A O   1 
ATOM   1120 C CB  . VAL A 1 332 ? -15.349 71.253  88.890  1.00 74.49  ? 313 VAL A CB  1 
ATOM   1121 C CG1 . VAL A 1 332 ? -15.450 72.361  89.902  1.00 73.53  ? 313 VAL A CG1 1 
ATOM   1122 C CG2 . VAL A 1 332 ? -16.689 71.004  88.259  1.00 72.81  ? 313 VAL A CG2 1 
ATOM   1123 N N   . GLY A 1 333 ? -13.282 69.405  87.838  1.00 75.97  ? 314 GLY A N   1 
ATOM   1124 C CA  . GLY A 1 333 ? -12.921 68.066  87.357  1.00 68.85  ? 314 GLY A CA  1 
ATOM   1125 C C   . GLY A 1 333 ? -11.511 67.969  86.863  1.00 69.00  ? 314 GLY A C   1 
ATOM   1126 O O   . GLY A 1 333 ? -10.994 66.885  86.880  1.00 71.19  ? 314 GLY A O   1 
ATOM   1127 N N   . GLY A 1 334 ? -10.890 69.087  86.553  1.00 72.91  ? 315 GLY A N   1 
ATOM   1128 C CA  . GLY A 1 334 ? -9.498  69.053  86.084  1.00 74.23  ? 315 GLY A CA  1 
ATOM   1129 C C   . GLY A 1 334 ? -9.276  68.045  84.987  1.00 72.17  ? 315 GLY A C   1 
ATOM   1130 O O   . GLY A 1 334 ? -9.826  68.230  83.933  1.00 72.46  ? 315 GLY A O   1 
ATOM   1131 N N   . ARG A 1 335 ? -8.513  66.997  85.268  1.00 70.69  ? 316 ARG A N   1 
ATOM   1132 C CA  . ARG A 1 335 ? -8.228  65.978  84.267  1.00 61.92  ? 316 ARG A CA  1 
ATOM   1133 C C   . ARG A 1 335 ? -9.394  65.024  84.049  1.00 68.53  ? 316 ARG A C   1 
ATOM   1134 O O   . ARG A 1 335 ? -9.239  64.040  83.333  1.00 74.05  ? 316 ARG A O   1 
ATOM   1135 C CB  . ARG A 1 335 ? -6.994  65.211  84.686  1.00 56.62  ? 316 ARG A CB  1 
ATOM   1136 C CG  . ARG A 1 335 ? -5.742  65.842  84.232  1.00 50.58  ? 316 ARG A CG  1 
ATOM   1137 C CD  . ARG A 1 335 ? -4.583  65.173  84.902  1.00 56.82  ? 316 ARG A CD  1 
ATOM   1138 N NE  . ARG A 1 335 ? -4.340  65.616  86.267  1.00 60.07  ? 316 ARG A NE  1 
ATOM   1139 C CZ  . ARG A 1 335 ? -3.329  65.191  87.011  1.00 62.71  ? 316 ARG A CZ  1 
ATOM   1140 N NH1 . ARG A 1 335 ? -2.477  64.300  86.530  1.00 62.69  ? 316 ARG A NH1 1 
ATOM   1141 N NH2 . ARG A 1 335 ? -3.155  65.676  88.233  1.00 73.68  ? 316 ARG A NH2 1 
ATOM   1142 N N   . VAL A 1 336 ? -10.537 65.268  84.670  1.00 71.62  ? 317 VAL A N   1 
ATOM   1143 C CA  . VAL A 1 336 ? -11.788 64.635  84.286  1.00 65.14  ? 317 VAL A CA  1 
ATOM   1144 C C   . VAL A 1 336 ? -12.514 65.682  83.457  1.00 73.08  ? 317 VAL A C   1 
ATOM   1145 O O   . VAL A 1 336 ? -13.213 66.547  83.977  1.00 78.09  ? 317 VAL A O   1 
ATOM   1146 C CB  . VAL A 1 336 ? -12.595 64.180  85.492  1.00 65.40  ? 317 VAL A CB  1 
ATOM   1147 C CG1 . VAL A 1 336 ? -13.995 63.771  85.063  1.00 64.95  ? 317 VAL A CG1 1 
ATOM   1148 C CG2 . VAL A 1 336 ? -11.864 63.044  86.184  1.00 63.52  ? 317 VAL A CG2 1 
ATOM   1149 N N   . ALA A 1 337 ? -12.282 65.632  82.152  1.00 77.87  ? 318 ALA A N   1 
ATOM   1150 C CA  . ALA A 1 337 ? -12.883 66.514  81.166  1.00 73.62  ? 318 ALA A CA  1 
ATOM   1151 C C   . ALA A 1 337 ? -13.921 65.747  80.370  1.00 85.29  ? 318 ALA A C   1 
ATOM   1152 O O   . ALA A 1 337 ? -13.723 64.573  80.045  1.00 95.47  ? 318 ALA A O   1 
ATOM   1153 C CB  . ALA A 1 337 ? -11.829 67.050  80.205  1.00 75.17  ? 318 ALA A CB  1 
ATOM   1154 N N   . THR A 1 338 ? -15.016 66.406  80.034  1.00 85.50  ? 319 THR A N   1 
ATOM   1155 C CA  . THR A 1 338 ? -16.030 65.770  79.213  1.00 83.19  ? 319 THR A CA  1 
ATOM   1156 C C   . THR A 1 338 ? -16.470 66.753  78.153  1.00 89.64  ? 319 THR A C   1 
ATOM   1157 O O   . THR A 1 338 ? -16.883 67.873  78.474  1.00 89.72  ? 319 THR A O   1 
ATOM   1158 C CB  . THR A 1 338 ? -17.220 65.318  80.041  1.00 86.98  ? 319 THR A CB  1 
ATOM   1159 O OG1 . THR A 1 338 ? -16.841 64.195  80.844  1.00 84.92  ? 319 THR A OG1 1 
ATOM   1160 C CG2 . THR A 1 338 ? -18.357 64.939  79.144  1.00 90.63  ? 319 THR A CG2 1 
ATOM   1161 N N   . PHE A 1 339 ? -16.353 66.334  76.898  1.00 97.71  ? 320 PHE A N   1 
ATOM   1162 C CA  . PHE A 1 339 ? -16.882 67.105  75.791  1.00 93.67  ? 320 PHE A CA  1 
ATOM   1163 C C   . PHE A 1 339 ? -18.381 66.877  75.703  1.00 93.63  ? 320 PHE A C   1 
ATOM   1164 O O   . PHE A 1 339 ? -18.861 65.754  75.900  1.00 91.10  ? 320 PHE A O   1 
ATOM   1165 C CB  . PHE A 1 339 ? -16.203 66.712  74.485  1.00 90.71  ? 320 PHE A CB  1 
ATOM   1166 C CG  . PHE A 1 339 ? -16.785 67.389  73.281  1.00 98.58  ? 320 PHE A CG  1 
ATOM   1167 C CD1 . PHE A 1 339 ? -16.484 68.713  73.004  1.00 100.01 ? 320 PHE A CD1 1 
ATOM   1168 C CD2 . PHE A 1 339 ? -17.645 66.707  72.433  1.00 97.88  ? 320 PHE A CD2 1 
ATOM   1169 C CE1 . PHE A 1 339 ? -17.029 69.340  71.895  1.00 107.53 ? 320 PHE A CE1 1 
ATOM   1170 C CE2 . PHE A 1 339 ? -18.190 67.324  71.335  1.00 97.80  ? 320 PHE A CE2 1 
ATOM   1171 C CZ  . PHE A 1 339 ? -17.882 68.645  71.058  1.00 103.03 ? 320 PHE A CZ  1 
ATOM   1172 N N   . ARG A 1 340 ? -19.118 67.963  75.446  1.00 92.63  ? 321 ARG A N   1 
ATOM   1173 C CA  . ARG A 1 340 ? -20.566 67.927  75.287  1.00 91.75  ? 321 ARG A CA  1 
ATOM   1174 C C   . ARG A 1 340 ? -20.997 68.935  74.229  1.00 100.10 ? 321 ARG A C   1 
ATOM   1175 O O   . ARG A 1 340 ? -20.590 70.100  74.261  1.00 102.96 ? 321 ARG A O   1 
ATOM   1176 C CB  . ARG A 1 340 ? -21.275 68.199  76.612  1.00 82.76  ? 321 ARG A CB  1 
ATOM   1177 C CG  . ARG A 1 340 ? -21.176 67.046  77.587  1.00 86.59  ? 321 ARG A CG  1 
ATOM   1178 C CD  . ARG A 1 340 ? -21.332 67.492  79.029  1.00 87.32  ? 321 ARG A CD  1 
ATOM   1179 N NE  . ARG A 1 340 ? -21.175 66.377  79.954  1.00 95.07  ? 321 ARG A NE  1 
ATOM   1180 C CZ  . ARG A 1 340 ? -22.083 65.421  80.130  1.00 101.22 ? 321 ARG A CZ  1 
ATOM   1181 N NH1 . ARG A 1 340 ? -23.224 65.455  79.439  1.00 103.98 ? 321 ARG A NH1 1 
ATOM   1182 N NH2 . ARG A 1 340 ? -21.849 64.426  80.987  1.00 92.76  ? 321 ARG A NH2 1 
ATOM   1183 N N   . LYS A 1 341 ? -21.793 68.460  73.276  1.00 105.12 ? 322 LYS A N   1 
ATOM   1184 C CA  . LYS A 1 341 ? -22.381 69.287  72.227  1.00 102.40 ? 322 LYS A CA  1 
ATOM   1185 C C   . LYS A 1 341 ? -23.575 68.507  71.706  1.00 106.82 ? 322 LYS A C   1 
ATOM   1186 O O   . LYS A 1 341 ? -23.412 67.391  71.201  1.00 107.10 ? 322 LYS A O   1 
ATOM   1187 C CB  . LYS A 1 341 ? -21.367 69.590  71.116  1.00 97.43  ? 322 LYS A CB  1 
ATOM   1188 C CG  . LYS A 1 341 ? -21.604 70.903  70.384  1.00 101.08 ? 322 LYS A CG  1 
ATOM   1189 C CD  . LYS A 1 341 ? -20.464 71.249  69.417  1.00 102.26 ? 322 LYS A CD  1 
ATOM   1190 C CE  . LYS A 1 341 ? -20.553 72.720  68.983  1.00 112.58 ? 322 LYS A CE  1 
ATOM   1191 N NZ  . LYS A 1 341 ? -19.877 73.056  67.683  1.00 116.44 ? 322 LYS A NZ  1 
ATOM   1192 N N   . GLY A 1 342 ? -24.768 69.057  71.871  1.00 106.82 ? 323 GLY A N   1 
ATOM   1193 C CA  . GLY A 1 342 ? -25.961 68.310  71.515  1.00 106.89 ? 323 GLY A CA  1 
ATOM   1194 C C   . GLY A 1 342 ? -26.044 67.017  72.306  1.00 107.52 ? 323 GLY A C   1 
ATOM   1195 O O   . GLY A 1 342 ? -26.084 67.022  73.540  1.00 107.66 ? 323 GLY A O   1 
ATOM   1196 N N   . ASN A 1 343 ? -26.077 65.889  71.589  1.00 108.88 ? 324 ASN A N   1 
ATOM   1197 C CA  . ASN A 1 343 ? -26.079 64.562  72.189  1.00 100.68 ? 324 ASN A CA  1 
ATOM   1198 C C   . ASN A 1 343 ? -24.695 63.945  72.192  1.00 104.11 ? 324 ASN A C   1 
ATOM   1199 O O   . ASN A 1 343 ? -24.506 62.852  72.747  1.00 99.16  ? 324 ASN A O   1 
ATOM   1200 C CB  . ASN A 1 343 ? -27.026 63.636  71.438  1.00 108.17 ? 324 ASN A CB  1 
ATOM   1201 C CG  . ASN A 1 343 ? -28.325 64.310  71.066  1.00 121.13 ? 324 ASN A CG  1 
ATOM   1202 O OD1 . ASN A 1 343 ? -28.571 64.600  69.882  1.00 122.18 ? 324 ASN A OD1 1 
ATOM   1203 N ND2 . ASN A 1 343 ? -29.155 64.597  72.070  1.00 118.57 ? 324 ASN A ND2 1 
ATOM   1204 N N   . TYR A 1 344 ? -23.734 64.613  71.564  1.00 106.56 ? 325 TYR A N   1 
ATOM   1205 C CA  . TYR A 1 344 ? -22.358 64.149  71.582  1.00 109.88 ? 325 TYR A CA  1 
ATOM   1206 C C   . TYR A 1 344 ? -21.767 64.319  72.977  1.00 106.24 ? 325 TYR A C   1 
ATOM   1207 O O   . TYR A 1 344 ? -21.910 65.371  73.608  1.00 102.39 ? 325 TYR A O   1 
ATOM   1208 C CB  . TYR A 1 344 ? -21.535 64.912  70.546  1.00 108.53 ? 325 TYR A CB  1 
ATOM   1209 C CG  . TYR A 1 344 ? -21.954 64.646  69.114  1.00 116.10 ? 325 TYR A CG  1 
ATOM   1210 C CD1 . TYR A 1 344 ? -21.804 65.632  68.136  1.00 119.53 ? 325 TYR A CD1 1 
ATOM   1211 C CD2 . TYR A 1 344 ? -22.491 63.412  68.733  1.00 114.41 ? 325 TYR A CD2 1 
ATOM   1212 C CE1 . TYR A 1 344 ? -22.185 65.402  66.818  1.00 123.90 ? 325 TYR A CE1 1 
ATOM   1213 C CE2 . TYR A 1 344 ? -22.879 63.172  67.418  1.00 116.71 ? 325 TYR A CE2 1 
ATOM   1214 C CZ  . TYR A 1 344 ? -22.723 64.173  66.464  1.00 123.06 ? 325 TYR A CZ  1 
ATOM   1215 O OH  . TYR A 1 344 ? -23.098 63.968  65.152  1.00 122.87 ? 325 TYR A OH  1 
ATOM   1216 N N   . VAL A 1 345 ? -21.114 63.268  73.458  1.00 105.17 ? 326 VAL A N   1 
ATOM   1217 C CA  . VAL A 1 345 ? -20.497 63.231  74.776  1.00 96.88  ? 326 VAL A CA  1 
ATOM   1218 C C   . VAL A 1 345 ? -19.261 62.352  74.710  1.00 100.10 ? 326 VAL A C   1 
ATOM   1219 O O   . VAL A 1 345 ? -19.344 61.177  74.340  1.00 104.93 ? 326 VAL A O   1 
ATOM   1220 C CB  . VAL A 1 345 ? -21.492 62.702  75.817  1.00 96.34  ? 326 VAL A CB  1 
ATOM   1221 C CG1 . VAL A 1 345 ? -20.753 62.147  77.015  1.00 97.43  ? 326 VAL A CG1 1 
ATOM   1222 C CG2 . VAL A 1 345 ? -22.450 63.805  76.220  1.00 98.60  ? 326 VAL A CG2 1 
ATOM   1223 N N   . ALA A 1 346 ? -18.104 62.895  75.059  1.00 98.09  ? 327 ALA A N   1 
ATOM   1224 C CA  . ALA A 1 346 ? -16.902 62.069  75.013  1.00 100.04 ? 327 ALA A CA  1 
ATOM   1225 C C   . ALA A 1 346 ? -15.862 62.622  75.973  1.00 95.40  ? 327 ALA A C   1 
ATOM   1226 O O   . ALA A 1 346 ? -15.465 63.786  75.845  1.00 97.09  ? 327 ALA A O   1 
ATOM   1227 C CB  . ALA A 1 346 ? -16.357 62.016  73.595  1.00 95.56  ? 327 ALA A CB  1 
ATOM   1228 N N   . ASP A 1 347 ? -15.404 61.791  76.908  1.00 82.08  ? 328 ASP A N   1 
ATOM   1229 C CA  . ASP A 1 347 ? -14.372 62.218  77.839  1.00 85.19  ? 328 ASP A CA  1 
ATOM   1230 C C   . ASP A 1 347 ? -13.052 62.445  77.111  1.00 87.02  ? 328 ASP A C   1 
ATOM   1231 O O   . ASP A 1 347 ? -12.451 61.505  76.584  1.00 81.50  ? 328 ASP A O   1 
ATOM   1232 C CB  . ASP A 1 347 ? -14.170 61.182  78.935  1.00 87.74  ? 328 ASP A CB  1 
ATOM   1233 C CG  . ASP A 1 347 ? -15.347 61.075  79.858  1.00 94.27  ? 328 ASP A CG  1 
ATOM   1234 O OD1 . ASP A 1 347 ? -16.056 60.048  79.768  1.00 102.57 ? 328 ASP A OD1 1 
ATOM   1235 O OD2 . ASP A 1 347 ? -15.558 61.995  80.676  1.00 91.85  ? 328 ASP A OD2 1 
ATOM   1236 N N   . LEU A 1 348 ? -12.587 63.691  77.109  1.00 88.54  ? 329 LEU A N   1 
ATOM   1237 C CA  . LEU A 1 348 ? -11.193 63.963  76.798  1.00 81.63  ? 329 LEU A CA  1 
ATOM   1238 C C   . LEU A 1 348 ? -10.256 63.470  77.892  1.00 82.63  ? 329 LEU A C   1 
ATOM   1239 O O   . LEU A 1 348 ? -9.041  63.404  77.671  1.00 76.25  ? 329 LEU A O   1 
ATOM   1240 C CB  . LEU A 1 348 ? -11.029 65.453  76.623  1.00 85.22  ? 329 LEU A CB  1 
ATOM   1241 C CG  . LEU A 1 348 ? -11.857 66.011  75.480  1.00 89.18  ? 329 LEU A CG  1 
ATOM   1242 C CD1 . LEU A 1 348 ? -11.948 67.524  75.627  1.00 90.52  ? 329 LEU A CD1 1 
ATOM   1243 C CD2 . LEU A 1 348 ? -11.148 65.645  74.194  1.00 86.60  ? 329 LEU A CD2 1 
ATOM   1244 N N   . GLY A 1 349 ? -10.797 63.146  79.072  1.00 83.73  ? 330 GLY A N   1 
ATOM   1245 C CA  . GLY A 1 349 ? -10.004 62.827  80.240  1.00 77.89  ? 330 GLY A CA  1 
ATOM   1246 C C   . GLY A 1 349 ? -10.111 61.370  80.590  1.00 79.63  ? 330 GLY A C   1 
ATOM   1247 O O   . GLY A 1 349 ? -9.972  60.524  79.715  1.00 90.94  ? 330 GLY A O   1 
ATOM   1248 N N   . ALA A 1 350 ? -10.347 61.051  81.851  1.00 77.88  ? 331 ALA A N   1 
ATOM   1249 C CA  . ALA A 1 350 ? -10.558 59.663  82.213  1.00 79.16  ? 331 ALA A CA  1 
ATOM   1250 C C   . ALA A 1 350 ? -11.858 59.141  81.605  1.00 84.82  ? 331 ALA A C   1 
ATOM   1251 O O   . ALA A 1 350 ? -12.798 59.900  81.346  1.00 87.67  ? 331 ALA A O   1 
ATOM   1252 C CB  . ALA A 1 350 ? -10.579 59.511  83.727  1.00 75.79  ? 331 ALA A CB  1 
ATOM   1253 N N   . MET A 1 351 ? -11.890 57.824  81.377  1.00 84.24  ? 332 MET A N   1 
ATOM   1254 C CA  . MET A 1 351 ? -13.002 57.118  80.753  1.00 82.81  ? 332 MET A CA  1 
ATOM   1255 C C   . MET A 1 351 ? -13.372 55.885  81.544  1.00 84.43  ? 332 MET A C   1 
ATOM   1256 O O   . MET A 1 351 ? -14.519 55.439  81.506  1.00 92.65  ? 332 MET A O   1 
ATOM   1257 C CB  . MET A 1 351 ? -12.643 56.614  79.373  1.00 87.58  ? 332 MET A CB  1 
ATOM   1258 C CG  . MET A 1 351 ? -12.455 57.614  78.321  1.00 95.23  ? 332 MET A CG  1 
ATOM   1259 S SD  . MET A 1 351 ? -11.925 56.660  76.896  1.00 112.74 ? 332 MET A SD  1 
ATOM   1260 C CE  . MET A 1 351 ? -10.264 56.142  77.386  1.00 96.80  ? 332 MET A CE  1 
ATOM   1261 N N   . VAL A 1 352 ? -12.390 55.277  82.196  1.00 78.17  ? 333 VAL A N   1 
ATOM   1262 C CA  . VAL A 1 352 ? -12.503 53.903  82.653  1.00 84.87  ? 333 VAL A CA  1 
ATOM   1263 C C   . VAL A 1 352 ? -12.540 53.861  84.170  1.00 84.67  ? 333 VAL A C   1 
ATOM   1264 O O   . VAL A 1 352 ? -11.759 54.538  84.851  1.00 86.45  ? 333 VAL A O   1 
ATOM   1265 C CB  . VAL A 1 352 ? -11.350 53.040  82.111  1.00 86.63  ? 333 VAL A CB  1 
ATOM   1266 C CG1 . VAL A 1 352 ? -11.573 51.597  82.472  1.00 89.13  ? 333 VAL A CG1 1 
ATOM   1267 C CG2 . VAL A 1 352 ? -11.248 53.199  80.641  1.00 85.62  ? 333 VAL A CG2 1 
ATOM   1268 N N   . VAL A 1 353 ? -13.445 53.051  84.684  1.00 79.69  ? 334 VAL A N   1 
ATOM   1269 C CA  . VAL A 1 353 ? -13.515 52.798  86.137  1.00 79.32  ? 334 VAL A CA  1 
ATOM   1270 C C   . VAL A 1 353 ? -12.916 51.415  86.246  1.00 81.01  ? 334 VAL A C   1 
ATOM   1271 O O   . VAL A 1 353 ? -13.521 50.504  85.780  1.00 87.65  ? 334 VAL A O   1 
ATOM   1272 C CB  . VAL A 1 353 ? -14.968 52.822  86.588  1.00 76.63  ? 334 VAL A CB  1 
ATOM   1273 C CG1 . VAL A 1 353 ? -15.073 52.594  88.071  1.00 76.20  ? 334 VAL A CG1 1 
ATOM   1274 C CG2 . VAL A 1 353 ? -15.598 54.138  86.215  1.00 76.26  ? 334 VAL A CG2 1 
ATOM   1275 N N   . THR A 1 354 ? -11.791 51.266  86.908  1.00 78.44  ? 335 THR A N   1 
ATOM   1276 C CA  . THR A 1 354 ? -11.115 49.971  86.782  1.00 75.30  ? 335 THR A CA  1 
ATOM   1277 C C   . THR A 1 354 ? -11.644 48.894  87.709  1.00 84.19  ? 335 THR A C   1 
ATOM   1278 O O   . THR A 1 354 ? -10.874 48.444  88.515  1.00 94.77  ? 335 THR A O   1 
ATOM   1279 C CB  . THR A 1 354 ? -9.623  50.178  87.010  1.00 76.99  ? 335 THR A CB  1 
ATOM   1280 O OG1 . THR A 1 354 ? -9.382  50.002  88.398  1.00 86.50  ? 335 THR A OG1 1 
ATOM   1281 C CG2 . THR A 1 354 ? -9.186  51.565  86.631  1.00 83.74  ? 335 THR A CG2 1 
ATOM   1282 N N   . GLY A 1 355 ? -12.891 48.480  87.615  1.00 80.16  ? 336 GLY A N   1 
ATOM   1283 C CA  . GLY A 1 355 ? -13.264 47.323  88.441  1.00 87.11  ? 336 GLY A CA  1 
ATOM   1284 C C   . GLY A 1 355 ? -13.839 47.725  89.762  1.00 81.02  ? 336 GLY A C   1 
ATOM   1285 O O   . GLY A 1 355 ? -13.182 48.406  90.467  1.00 86.32  ? 336 GLY A O   1 
ATOM   1286 N N   . LEU A 1 356 ? -14.963 47.161  90.152  1.00 78.29  ? 337 LEU A N   1 
ATOM   1287 C CA  . LEU A 1 356 ? -15.593 47.625  91.403  1.00 78.56  ? 337 LEU A CA  1 
ATOM   1288 C C   . LEU A 1 356 ? -15.129 46.813  92.599  1.00 81.21  ? 337 LEU A C   1 
ATOM   1289 O O   . LEU A 1 356 ? -15.615 47.072  93.678  1.00 84.29  ? 337 LEU A O   1 
ATOM   1290 C CB  . LEU A 1 356 ? -17.097 47.525  91.219  1.00 68.89  ? 337 LEU A CB  1 
ATOM   1291 C CG  . LEU A 1 356 ? -17.568 48.135  89.916  1.00 66.03  ? 337 LEU A CG  1 
ATOM   1292 C CD1 . LEU A 1 356 ? -19.034 48.451  89.992  1.00 70.36  ? 337 LEU A CD1 1 
ATOM   1293 C CD2 . LEU A 1 356 ? -16.795 49.391  89.655  1.00 71.92  ? 337 LEU A CD2 1 
ATOM   1294 N N   . GLY A 1 357 ? -14.179 45.914  92.434  1.00 81.10  ? 338 GLY A N   1 
ATOM   1295 C CA  . GLY A 1 357 ? -13.826 45.140  93.627  1.00 83.14  ? 338 GLY A CA  1 
ATOM   1296 C C   . GLY A 1 357 ? -12.920 45.943  94.515  1.00 82.66  ? 338 GLY A C   1 
ATOM   1297 O O   . GLY A 1 357 ? -11.726 45.879  94.334  1.00 86.02  ? 338 GLY A O   1 
ATOM   1298 N N   . GLY A 1 358 ? -13.493 46.592  95.517  1.00 85.69  ? 339 GLY A N   1 
ATOM   1299 C CA  . GLY A 1 358 ? -12.691 47.408  96.438  1.00 83.03  ? 339 GLY A CA  1 
ATOM   1300 C C   . GLY A 1 358 ? -12.461 48.793  95.902  1.00 79.03  ? 339 GLY A C   1 
ATOM   1301 O O   . GLY A 1 358 ? -11.577 49.447  96.365  1.00 80.68  ? 339 GLY A O   1 
ATOM   1302 N N   . ASN A 1 359 ? -13.275 49.225  94.966  1.00 80.34  ? 340 ASN A N   1 
ATOM   1303 C CA  . ASN A 1 359 ? -13.037 50.550  94.369  1.00 78.47  ? 340 ASN A CA  1 
ATOM   1304 C C   . ASN A 1 359 ? -13.975 51.582  94.961  1.00 82.39  ? 340 ASN A C   1 
ATOM   1305 O O   . ASN A 1 359 ? -15.160 51.393  94.884  1.00 84.42  ? 340 ASN A O   1 
ATOM   1306 C CB  . ASN A 1 359 ? -13.375 50.480  92.897  1.00 79.36  ? 340 ASN A CB  1 
ATOM   1307 C CG  . ASN A 1 359 ? -12.933 51.706  92.160  1.00 81.37  ? 340 ASN A CG  1 
ATOM   1308 O OD1 . ASN A 1 359 ? -12.968 52.776  92.718  1.00 83.68  ? 340 ASN A OD1 1 
ATOM   1309 N ND2 . ASN A 1 359 ? -12.508 51.549  90.929  1.00 83.82  ? 340 ASN A ND2 1 
ATOM   1310 N N   . PRO A 1 360 ? -13.469 52.676  95.540  1.00 83.32  ? 341 PRO A N   1 
ATOM   1311 C CA  . PRO A 1 360 ? -14.305 53.705  96.076  1.00 79.08  ? 341 PRO A CA  1 
ATOM   1312 C C   . PRO A 1 360 ? -15.231 54.227  94.985  1.00 76.20  ? 341 PRO A C   1 
ATOM   1313 O O   . PRO A 1 360 ? -16.250 54.695  95.325  1.00 79.56  ? 341 PRO A O   1 
ATOM   1314 C CB  . PRO A 1 360 ? -13.323 54.788  96.480  1.00 76.47  ? 341 PRO A CB  1 
ATOM   1315 C CG  . PRO A 1 360 ? -12.067 54.416  95.792  1.00 77.72  ? 341 PRO A CG  1 
ATOM   1316 C CD  . PRO A 1 360 ? -12.084 52.915  95.803  1.00 84.20  ? 341 PRO A CD  1 
ATOM   1317 N N   . MET A 1 361 ? -14.836 54.174  93.722  1.00 75.86  ? 342 MET A N   1 
ATOM   1318 C CA  . MET A 1 361 ? -15.816 54.608  92.733  1.00 80.87  ? 342 MET A CA  1 
ATOM   1319 C C   . MET A 1 361 ? -17.080 53.762  92.786  1.00 82.62  ? 342 MET A C   1 
ATOM   1320 O O   . MET A 1 361 ? -18.144 54.241  92.378  1.00 81.90  ? 342 MET A O   1 
ATOM   1321 C CB  . MET A 1 361 ? -15.262 54.543  91.314  1.00 77.44  ? 342 MET A CB  1 
ATOM   1322 C CG  . MET A 1 361 ? -14.248 55.586  90.920  1.00 79.55  ? 342 MET A CG  1 
ATOM   1323 S SD  . MET A 1 361 ? -14.385 57.191  91.712  1.00 86.97  ? 342 MET A SD  1 
ATOM   1324 C CE  . MET A 1 361 ? -15.699 57.928  90.731  1.00 84.29  ? 342 MET A CE  1 
ATOM   1325 N N   . ALA A 1 362 ? -16.978 52.510  93.248  1.00 78.95  ? 343 ALA A N   1 
ATOM   1326 C CA  . ALA A 1 362 ? -18.167 51.683  93.415  1.00 77.14  ? 343 ALA A CA  1 
ATOM   1327 C C   . ALA A 1 362 ? -19.183 52.391  94.281  1.00 85.57  ? 343 ALA A C   1 
ATOM   1328 O O   . ALA A 1 362 ? -20.375 52.439  93.953  1.00 88.62  ? 343 ALA A O   1 
ATOM   1329 C CB  . ALA A 1 362 ? -17.799 50.336  94.031  1.00 80.62  ? 343 ALA A CB  1 
ATOM   1330 N N   . VAL A 1 363 ? -18.718 52.963  95.395  1.00 86.87  ? 344 VAL A N   1 
ATOM   1331 C CA  . VAL A 1 363 ? -19.594 53.749  96.254  1.00 82.80  ? 344 VAL A CA  1 
ATOM   1332 C C   . VAL A 1 363 ? -20.147 54.939  95.493  1.00 85.78  ? 344 VAL A C   1 
ATOM   1333 O O   . VAL A 1 363 ? -21.359 55.170  95.460  1.00 91.79  ? 344 VAL A O   1 
ATOM   1334 C CB  . VAL A 1 363 ? -18.841 54.203  97.508  1.00 81.74  ? 344 VAL A CB  1 
ATOM   1335 C CG1 . VAL A 1 363 ? -19.723 55.138  98.299  1.00 88.10  ? 344 VAL A CG1 1 
ATOM   1336 C CG2 . VAL A 1 363 ? -18.422 53.011  98.315  1.00 83.55  ? 344 VAL A CG2 1 
ATOM   1337 N N   . VAL A 1 364 ? -19.266 55.707  94.862  1.00 80.19  ? 345 VAL A N   1 
ATOM   1338 C CA  . VAL A 1 364 ? -19.697 56.935  94.209  1.00 83.64  ? 345 VAL A CA  1 
ATOM   1339 C C   . VAL A 1 364 ? -20.794 56.660  93.193  1.00 88.15  ? 345 VAL A C   1 
ATOM   1340 O O   . VAL A 1 364 ? -21.752 57.429  93.070  1.00 92.64  ? 345 VAL A O   1 
ATOM   1341 C CB  . VAL A 1 364 ? -18.496 57.629  93.554  1.00 82.79  ? 345 VAL A CB  1 
ATOM   1342 C CG1 . VAL A 1 364 ? -18.973 58.785  92.699  1.00 76.53  ? 345 VAL A CG1 1 
ATOM   1343 C CG2 . VAL A 1 364 ? -17.523 58.075  94.627  1.00 74.38  ? 345 VAL A CG2 1 
ATOM   1344 N N   . SER A 1 365 ? -20.674 55.564  92.448  1.00 94.23  ? 346 SER A N   1 
ATOM   1345 C CA  . SER A 1 365 ? -21.631 55.281  91.382  1.00 97.54  ? 346 SER A CA  1 
ATOM   1346 C C   . SER A 1 365 ? -23.021 55.034  91.940  1.00 96.62  ? 346 SER A C   1 
ATOM   1347 O O   . SER A 1 365 ? -24.025 55.397  91.315  1.00 99.42  ? 346 SER A O   1 
ATOM   1348 C CB  . SER A 1 365 ? -21.159 54.081  90.570  1.00 97.13  ? 346 SER A CB  1 
ATOM   1349 O OG  . SER A 1 365 ? -20.735 53.048  91.449  1.00 93.75  ? 346 SER A OG  1 
ATOM   1350 N N   . LYS A 1 366 ? -23.105 54.398  93.109  1.00 89.60  ? 347 LYS A N   1 
ATOM   1351 C CA  . LYS A 1 366 ? -24.411 54.296  93.732  1.00 92.97  ? 347 LYS A CA  1 
ATOM   1352 C C   . LYS A 1 366 ? -24.921 55.682  94.125  1.00 96.34  ? 347 LYS A C   1 
ATOM   1353 O O   . LYS A 1 366 ? -26.132 55.933  94.094  1.00 102.47 ? 347 LYS A O   1 
ATOM   1354 C CB  . LYS A 1 366 ? -24.346 53.326  94.920  1.00 90.82  ? 347 LYS A CB  1 
ATOM   1355 C CG  . LYS A 1 366 ? -23.864 51.903  94.536  1.00 92.91  ? 347 LYS A CG  1 
ATOM   1356 C CD  . LYS A 1 366 ? -23.926 50.855  95.691  1.00 98.13  ? 347 LYS A CD  1 
ATOM   1357 C CE  . LYS A 1 366 ? -25.365 50.515  96.133  1.00 102.38 ? 347 LYS A CE  1 
ATOM   1358 N NZ  . LYS A 1 366 ? -25.443 49.398  97.141  1.00 96.22  ? 347 LYS A NZ  1 
ATOM   1359 N N   . GLN A 1 367 ? -24.013 56.617  94.410  1.00 92.21  ? 348 GLN A N   1 
ATOM   1360 C CA  . GLN A 1 367 ? -24.412 57.921  94.930  1.00 95.62  ? 348 GLN A CA  1 
ATOM   1361 C C   . GLN A 1 367 ? -24.819 58.885  93.816  1.00 101.43 ? 348 GLN A C   1 
ATOM   1362 O O   . GLN A 1 367 ? -25.798 59.625  93.952  1.00 106.57 ? 348 GLN A O   1 
ATOM   1363 C CB  . GLN A 1 367 ? -23.275 58.516  95.760  1.00 90.02  ? 348 GLN A CB  1 
ATOM   1364 C CG  . GLN A 1 367 ? -23.066 57.875  97.112  1.00 89.92  ? 348 GLN A CG  1 
ATOM   1365 C CD  . GLN A 1 367 ? -21.901 58.492  97.851  1.00 87.46  ? 348 GLN A CD  1 
ATOM   1366 O OE1 . GLN A 1 367 ? -21.130 59.250  97.281  1.00 84.77  ? 348 GLN A OE1 1 
ATOM   1367 N NE2 . GLN A 1 367 ? -21.790 58.199  99.136  1.00 92.12  ? 348 GLN A NE2 1 
ATOM   1368 N N   . VAL A 1 368 ? -24.105 58.798  92.711  1.00 100.38 ? 349 VAL A N   1 
ATOM   1369 C CA  . VAL A 1 368 ? -24.466 59.616  91.532  1.00 102.10 ? 349 VAL A CA  1 
ATOM   1370 C C   . VAL A 1 368 ? -24.804 58.616  90.441  1.00 109.33 ? 349 VAL A C   1 
ATOM   1371 O O   . VAL A 1 368 ? -24.049 57.669  90.281  1.00 108.90 ? 349 VAL A O   1 
ATOM   1372 C CB  . VAL A 1 368 ? -23.283 60.479  91.105  1.00 98.58  ? 349 VAL A CB  1 
ATOM   1373 C CG1 . VAL A 1 368 ? -21.987 59.867  91.567  1.00 96.37  ? 349 VAL A CG1 1 
ATOM   1374 C CG2 . VAL A 1 368 ? -23.268 60.628  89.608  1.00 105.89 ? 349 VAL A CG2 1 
ATOM   1375 N N   . ASN A 1 369 ? -25.937 58.785  89.773  1.00 113.80 ? 350 ASN A N   1 
ATOM   1376 C CA  . ASN A 1 369 ? -26.282 57.833  88.695  1.00 121.06 ? 350 ASN A CA  1 
ATOM   1377 C C   . ASN A 1 369 ? -25.154 57.892  87.678  1.00 123.03 ? 350 ASN A C   1 
ATOM   1378 O O   . ASN A 1 369 ? -24.862 58.968  87.181  1.00 118.85 ? 350 ASN A O   1 
ATOM   1379 C CB  . ASN A 1 369 ? -27.633 58.146  88.057  1.00 126.15 ? 350 ASN A CB  1 
ATOM   1380 C CG  . ASN A 1 369 ? -27.524 58.892  86.746  1.00 133.14 ? 350 ASN A CG  1 
ATOM   1381 O OD1 . ASN A 1 369 ? -27.111 60.045  86.714  1.00 136.36 ? 350 ASN A OD1 1 
ATOM   1382 N ND2 . ASN A 1 369 ? -27.922 58.254  85.661  1.00 128.22 ? 350 ASN A ND2 1 
ATOM   1383 N N   . MET A 1 370 ? -24.501 56.771  87.438  1.00 118.19 ? 351 MET A N   1 
ATOM   1384 C CA  . MET A 1 370 ? -23.409 56.801  86.450  1.00 115.58 ? 351 MET A CA  1 
ATOM   1385 C C   . MET A 1 370 ? -23.691 55.683  85.463  1.00 120.92 ? 351 MET A C   1 
ATOM   1386 O O   . MET A 1 370 ? -23.815 54.544  85.899  1.00 120.01 ? 351 MET A O   1 
ATOM   1387 C CB  . MET A 1 370 ? -22.079 56.523  87.139  1.00 115.47 ? 351 MET A CB  1 
ATOM   1388 C CG  . MET A 1 370 ? -21.090 57.645  87.033  1.00 109.13 ? 351 MET A CG  1 
ATOM   1389 S SD  . MET A 1 370 ? -19.604 57.221  87.944  1.00 111.27 ? 351 MET A SD  1 
ATOM   1390 C CE  . MET A 1 370 ? -20.309 56.290  89.298  1.00 92.63  ? 351 MET A CE  1 
ATOM   1391 N N   . GLU A 1 371 ? -23.841 56.019  84.190  1.00 118.12 ? 352 GLU A N   1 
ATOM   1392 C CA  . GLU A 1 371 ? -24.087 54.975  83.178  1.00 116.73 ? 352 GLU A CA  1 
ATOM   1393 C C   . GLU A 1 371 ? -22.798 54.184  83.062  1.00 109.52 ? 352 GLU A C   1 
ATOM   1394 O O   . GLU A 1 371 ? -21.941 54.610  82.307  1.00 105.77 ? 352 GLU A O   1 
ATOM   1395 C CB  . GLU A 1 371 ? -24.366 55.634  81.834  1.00 120.88 ? 352 GLU A CB  1 
ATOM   1396 C CG  . GLU A 1 371 ? -25.834 55.653  81.467  1.00 132.51 ? 352 GLU A CG  1 
ATOM   1397 C CD  . GLU A 1 371 ? -26.122 56.164  80.068  1.00 140.76 ? 352 GLU A CD  1 
ATOM   1398 O OE1 . GLU A 1 371 ? -25.955 57.374  79.841  1.00 133.54 ? 352 GLU A OE1 1 
ATOM   1399 O OE2 . GLU A 1 371 ? -26.519 55.353  79.212  1.00 145.19 ? 352 GLU A OE2 1 
ATOM   1400 N N   . LEU A 1 372 ? -22.689 53.085  83.797  1.00 103.81 ? 353 LEU A N   1 
ATOM   1401 C CA  . LEU A 1 372 ? -21.451 52.278  83.772  1.00 103.16 ? 353 LEU A CA  1 
ATOM   1402 C C   . LEU A 1 372 ? -21.620 51.099  82.825  1.00 104.27 ? 353 LEU A C   1 
ATOM   1403 O O   . LEU A 1 372 ? -22.312 50.165  83.191  1.00 101.82 ? 353 LEU A O   1 
ATOM   1404 C CB  . LEU A 1 372 ? -21.182 51.778  85.185  1.00 103.30 ? 353 LEU A CB  1 
ATOM   1405 C CG  . LEU A 1 372 ? -19.858 52.256  85.750  1.00 95.49  ? 353 LEU A CG  1 
ATOM   1406 C CD1 . LEU A 1 372 ? -19.632 53.683  85.329  1.00 92.19  ? 353 LEU A CD1 1 
ATOM   1407 C CD2 . LEU A 1 372 ? -19.847 52.145  87.248  1.00 86.54  ? 353 LEU A CD2 1 
ATOM   1408 N N   . ALA A 1 373 ? -20.962 51.157  81.672  1.00 105.47 ? 354 ALA A N   1 
ATOM   1409 C CA  . ALA A 1 373 ? -21.038 50.100  80.646  1.00 95.93  ? 354 ALA A CA  1 
ATOM   1410 C C   . ALA A 1 373 ? -19.726 49.337  80.638  1.00 99.65  ? 354 ALA A C   1 
ATOM   1411 O O   . ALA A 1 373 ? -18.688 49.972  80.641  1.00 99.07  ? 354 ALA A O   1 
ATOM   1412 C CB  . ALA A 1 373 ? -21.265 50.741  79.316  1.00 91.98  ? 354 ALA A CB  1 
ATOM   1413 N N   . LYS A 1 374 ? -19.787 48.017  80.537  1.00 102.31 ? 355 LYS A N   1 
ATOM   1414 C CA  . LYS A 1 374 ? -18.553 47.208  80.591  1.00 101.93 ? 355 LYS A CA  1 
ATOM   1415 C C   . LYS A 1 374 ? -17.767 47.286  79.291  1.00 100.99 ? 355 LYS A C   1 
ATOM   1416 O O   . LYS A 1 374 ? -18.292 47.704  78.283  1.00 103.94 ? 355 LYS A O   1 
ATOM   1417 C CB  . LYS A 1 374 ? -18.901 45.736  80.781  1.00 99.55  ? 355 LYS A CB  1 
ATOM   1418 C CG  . LYS A 1 374 ? -19.688 45.405  82.035  1.00 103.90 ? 355 LYS A CG  1 
ATOM   1419 C CD  . LYS A 1 374 ? -19.564 43.951  82.427  1.00 112.96 ? 355 LYS A CD  1 
ATOM   1420 C CE  . LYS A 1 374 ? -20.108 43.649  83.808  1.00 123.51 ? 355 LYS A CE  1 
ATOM   1421 N NZ  . LYS A 1 374 ? -19.651 42.337  84.324  1.00 113.59 ? 355 LYS A NZ  1 
ATOM   1422 N N   . ILE A 1 375 ? -16.518 46.877  79.375  1.00 97.45  ? 356 ILE A N   1 
ATOM   1423 C CA  . ILE A 1 375 ? -15.631 46.755  78.231  1.00 106.14 ? 356 ILE A CA  1 
ATOM   1424 C C   . ILE A 1 375 ? -15.606 45.309  77.776  1.00 118.31 ? 356 ILE A C   1 
ATOM   1425 O O   . ILE A 1 375 ? -15.215 44.415  78.539  1.00 119.62 ? 356 ILE A O   1 
ATOM   1426 C CB  . ILE A 1 375 ? -14.216 47.263  78.542  1.00 105.48 ? 356 ILE A CB  1 
ATOM   1427 C CG1 . ILE A 1 375 ? -14.187 48.783  78.572  1.00 102.84 ? 356 ILE A CG1 1 
ATOM   1428 C CG2 . ILE A 1 375 ? -13.165 46.618  77.656  1.00 109.94 ? 356 ILE A CG2 1 
ATOM   1429 C CD1 . ILE A 1 375 ? -12.861 49.316  79.012  1.00 102.29 ? 356 ILE A CD1 1 
ATOM   1430 N N   . LYS A 1 376 ? -16.042 45.085  76.533  1.00 120.51 ? 357 LYS A N   1 
ATOM   1431 C CA  . LYS A 1 376 ? -15.800 43.824  75.843  1.00 119.69 ? 357 LYS A CA  1 
ATOM   1432 C C   . LYS A 1 376 ? -14.349 43.845  75.369  1.00 114.92 ? 357 LYS A C   1 
ATOM   1433 O O   . LYS A 1 376 ? -13.992 44.585  74.446  1.00 110.39 ? 357 LYS A O   1 
ATOM   1434 C CB  . LYS A 1 376 ? -16.791 43.615  74.691  1.00 127.49 ? 357 LYS A CB  1 
ATOM   1435 C CG  . LYS A 1 376 ? -18.276 43.443  75.115  1.00 127.28 ? 357 LYS A CG  1 
ATOM   1436 C CD  . LYS A 1 376 ? -18.626 42.005  75.600  1.00 133.48 ? 357 LYS A CD  1 
ATOM   1437 C CE  . LYS A 1 376 ? -19.162 41.078  74.484  1.00 135.00 ? 357 LYS A CE  1 
ATOM   1438 N NZ  . LYS A 1 376 ? -19.887 39.858  75.014  1.00 124.74 ? 357 LYS A NZ  1 
ATOM   1439 N N   . GLN A 1 377 ? -13.522 43.036  76.031  1.00 117.32 ? 358 GLN A N   1 
ATOM   1440 C CA  . GLN A 1 377 ? -12.076 43.024  75.829  1.00 122.42 ? 358 GLN A CA  1 
ATOM   1441 C C   . GLN A 1 377 ? -11.682 42.783  74.371  1.00 125.32 ? 358 GLN A C   1 
ATOM   1442 O O   . GLN A 1 377 ? -10.574 43.163  73.965  1.00 125.44 ? 358 GLN A O   1 
ATOM   1443 C CB  . GLN A 1 377 ? -11.468 41.932  76.713  1.00 127.06 ? 358 GLN A CB  1 
ATOM   1444 C CG  . GLN A 1 377 ? -11.563 40.498  76.089  1.00 135.97 ? 358 GLN A CG  1 
ATOM   1445 C CD  . GLN A 1 377 ? -12.990 39.891  76.038  1.00 137.35 ? 358 GLN A CD  1 
ATOM   1446 O OE1 . GLN A 1 377 ? -13.998 40.609  76.110  1.00 138.96 ? 358 GLN A OE1 1 
ATOM   1447 N NE2 . GLN A 1 377 ? -13.065 38.565  75.871  1.00 126.07 ? 358 GLN A NE2 1 
ATOM   1448 N N   . LYS A 1 378 ? -12.544 42.128  73.581  1.00 123.58 ? 359 LYS A N   1 
ATOM   1449 C CA  . LYS A 1 378 ? -12.182 41.722  72.225  1.00 116.00 ? 359 LYS A CA  1 
ATOM   1450 C C   . LYS A 1 378 ? -11.780 42.917  71.384  1.00 109.16 ? 359 LYS A C   1 
ATOM   1451 O O   . LYS A 1 378 ? -12.589 43.811  71.129  1.00 109.55 ? 359 LYS A O   1 
ATOM   1452 C CB  . LYS A 1 378 ? -13.341 40.996  71.541  1.00 120.16 ? 359 LYS A CB  1 
ATOM   1453 C CG  . LYS A 1 378 ? -12.890 40.331  70.234  1.00 121.86 ? 359 LYS A CG  1 
ATOM   1454 C CD  . LYS A 1 378 ? -14.033 39.755  69.410  1.00 123.16 ? 359 LYS A CD  1 
ATOM   1455 C CE  . LYS A 1 378 ? -14.122 40.451  68.055  1.00 124.46 ? 359 LYS A CE  1 
ATOM   1456 N NZ  . LYS A 1 378 ? -14.887 39.635  67.066  1.00 125.41 ? 359 LYS A NZ  1 
ATOM   1457 N N   . CYS A 1 379 ? -10.532 42.924  70.939  1.00 103.18 ? 360 CYS A N   1 
ATOM   1458 C CA  . CYS A 1 379 ? -10.010 44.026  70.142  1.00 103.80 ? 360 CYS A CA  1 
ATOM   1459 C C   . CYS A 1 379 ? -9.394  43.474  68.870  1.00 103.71 ? 360 CYS A C   1 
ATOM   1460 O O   . CYS A 1 379 ? -8.342  42.803  68.936  1.00 106.05 ? 360 CYS A O   1 
ATOM   1461 C CB  . CYS A 1 379 ? -8.992  44.846  70.927  1.00 107.51 ? 360 CYS A CB  1 
ATOM   1462 S SG  . CYS A 1 379 ? -8.379  46.293  70.014  1.00 103.87 ? 360 CYS A SG  1 
ATOM   1463 N N   . PRO A 1 380 ? -10.007 43.710  67.714  1.00 99.95  ? 361 PRO A N   1 
ATOM   1464 C CA  . PRO A 1 380 ? -9.400  43.286  66.451  1.00 102.24 ? 361 PRO A CA  1 
ATOM   1465 C C   . PRO A 1 380 ? -8.384  44.286  65.937  1.00 102.67 ? 361 PRO A C   1 
ATOM   1466 O O   . PRO A 1 380 ? -8.624  45.494  65.915  1.00 103.99 ? 361 PRO A O   1 
ATOM   1467 C CB  . PRO A 1 380 ? -10.596 43.196  65.495  1.00 101.34 ? 361 PRO A CB  1 
ATOM   1468 C CG  . PRO A 1 380 ? -11.570 44.142  66.028  1.00 101.78 ? 361 PRO A CG  1 
ATOM   1469 C CD  . PRO A 1 380 ? -11.398 44.146  67.534  1.00 102.41 ? 361 PRO A CD  1 
ATOM   1470 N N   . LEU A 1 381 ? -7.252  43.760  65.484  1.00 106.98 ? 362 LEU A N   1 
ATOM   1471 C CA  . LEU A 1 381 ? -6.149  44.566  64.982  1.00 103.41 ? 362 LEU A CA  1 
ATOM   1472 C C   . LEU A 1 381 ? -6.154  44.553  63.457  1.00 98.86  ? 362 LEU A C   1 
ATOM   1473 O O   . LEU A 1 381 ? -6.392  43.514  62.839  1.00 110.73 ? 362 LEU A O   1 
ATOM   1474 C CB  . LEU A 1 381 ? -4.811  44.068  65.528  1.00 98.20  ? 362 LEU A CB  1 
ATOM   1475 C CG  . LEU A 1 381 ? -4.444  44.225  67.002  1.00 100.62 ? 362 LEU A CG  1 
ATOM   1476 C CD1 . LEU A 1 381 ? -5.495  43.622  67.933  1.00 108.27 ? 362 LEU A CD1 1 
ATOM   1477 C CD2 . LEU A 1 381 ? -3.111  43.523  67.220  1.00 106.90 ? 362 LEU A CD2 1 
ATOM   1478 N N   . TYR A 1 382 ? -5.874  45.714  62.878  1.00 88.18  ? 363 TYR A N   1 
ATOM   1479 C CA  . TYR A 1 382 ? -5.999  46.048  61.467  1.00 94.35  ? 363 TYR A CA  1 
ATOM   1480 C C   . TYR A 1 382 ? -4.651  46.617  61.049  1.00 101.28 ? 363 TYR A C   1 
ATOM   1481 O O   . TYR A 1 382 ? -4.186  47.606  61.627  1.00 104.05 ? 363 TYR A O   1 
ATOM   1482 C CB  . TYR A 1 382 ? -7.105  47.090  61.290  1.00 99.28  ? 363 TYR A CB  1 
ATOM   1483 C CG  . TYR A 1 382 ? -8.495  46.548  61.449  1.00 103.76 ? 363 TYR A CG  1 
ATOM   1484 C CD1 . TYR A 1 382 ? -9.298  46.310  60.341  1.00 105.48 ? 363 TYR A CD1 1 
ATOM   1485 C CD2 . TYR A 1 382 ? -8.937  46.081  62.673  1.00 110.29 ? 363 TYR A CD2 1 
ATOM   1486 C CE1 . TYR A 1 382 ? -10.569 45.763  60.496  1.00 110.64 ? 363 TYR A CE1 1 
ATOM   1487 C CE2 . TYR A 1 382 ? -10.188 45.508  62.831  1.00 110.34 ? 363 TYR A CE2 1 
ATOM   1488 C CZ  . TYR A 1 382 ? -11.000 45.351  61.737  1.00 111.67 ? 363 TYR A CZ  1 
ATOM   1489 O OH  . TYR A 1 382 ? -12.243 44.787  61.944  1.00 116.78 ? 363 TYR A OH  1 
ATOM   1490 N N   . GLU A 1 383 ? -4.007  46.076  60.025  1.00 108.52 ? 364 GLU A N   1 
ATOM   1491 C CA  . GLU A 1 383 ? -2.667  46.621  59.692  1.00 104.82 ? 364 GLU A CA  1 
ATOM   1492 C C   . GLU A 1 383 ? -2.752  47.886  58.841  1.00 108.44 ? 364 GLU A C   1 
ATOM   1493 O O   . GLU A 1 383 ? -3.836  48.332  58.498  1.00 109.53 ? 364 GLU A O   1 
ATOM   1494 C CB  . GLU A 1 383 ? -1.798  45.595  58.976  1.00 111.10 ? 364 GLU A CB  1 
ATOM   1495 C CG  . GLU A 1 383 ? -2.145  44.168  59.333  1.00 124.87 ? 364 GLU A CG  1 
ATOM   1496 C CD  . GLU A 1 383 ? -1.312  43.118  58.620  1.00 131.10 ? 364 GLU A CD  1 
ATOM   1497 O OE1 . GLU A 1 383 ? -0.138  43.391  58.347  1.00 128.07 ? 364 GLU A OE1 1 
ATOM   1498 O OE2 . GLU A 1 383 ? -1.843  42.031  58.343  1.00 130.09 ? 364 GLU A OE2 1 
ATOM   1499 N N   . ALA A 1 384 ? -1.611  48.331  58.335  1.00 104.12 ? 365 ALA A N   1 
ATOM   1500 C CA  . ALA A 1 384 ? -1.553  49.576  57.542  1.00 97.51  ? 365 ALA A CA  1 
ATOM   1501 C C   . ALA A 1 384 ? -2.438  49.468  56.305  1.00 114.70 ? 365 ALA A C   1 
ATOM   1502 O O   . ALA A 1 384 ? -3.084  50.450  55.961  1.00 112.41 ? 365 ALA A O   1 
ATOM   1503 C CB  . ALA A 1 384 ? -0.135  49.843  57.154  1.00 98.79  ? 365 ALA A CB  1 
ATOM   1504 N N   . ASN A 1 385 ? -2.481  48.296  55.676  1.00 118.95 ? 366 ASN A N   1 
ATOM   1505 C CA  . ASN A 1 385 ? -3.320  48.040  54.484  1.00 117.15 ? 366 ASN A CA  1 
ATOM   1506 C C   . ASN A 1 385 ? -4.806  48.220  54.803  1.00 121.22 ? 366 ASN A C   1 
ATOM   1507 O O   . ASN A 1 385 ? -5.513  48.644  53.905  1.00 123.75 ? 366 ASN A O   1 
ATOM   1508 C CB  . ASN A 1 385 ? -3.060  46.647  53.925  1.00 116.22 ? 366 ASN A CB  1 
ATOM   1509 C CG  . ASN A 1 385 ? -3.400  45.544  54.901  1.00 124.52 ? 366 ASN A CG  1 
ATOM   1510 O OD1 . ASN A 1 385 ? -3.897  45.804  55.980  1.00 121.38 ? 366 ASN A OD1 1 
ATOM   1511 N ND2 . ASN A 1 385 ? -3.134  44.306  54.533  1.00 128.41 ? 366 ASN A ND2 1 
ATOM   1512 N N   . GLY A 1 386 ? -5.257  47.951  56.026  1.00 116.73 ? 367 GLY A N   1 
ATOM   1513 C CA  . GLY A 1 386 ? -6.692  48.017  56.337  1.00 117.39 ? 367 GLY A CA  1 
ATOM   1514 C C   . GLY A 1 386 ? -7.278  46.625  56.377  1.00 118.99 ? 367 GLY A C   1 
ATOM   1515 O O   . GLY A 1 386 ? -8.498  46.495  56.376  1.00 122.43 ? 367 GLY A O   1 
ATOM   1516 N N   . GLN A 1 387 ? -6.416  45.617  56.368  1.00 115.49 ? 368 GLN A N   1 
ATOM   1517 C CA  . GLN A 1 387 ? -6.863  44.211  56.420  1.00 114.01 ? 368 GLN A CA  1 
ATOM   1518 C C   . GLN A 1 387 ? -6.589  43.689  57.826  1.00 107.26 ? 368 GLN A C   1 
ATOM   1519 O O   . GLN A 1 387 ? -5.500  43.886  58.321  1.00 107.43 ? 368 GLN A O   1 
ATOM   1520 C CB  . GLN A 1 387 ? -6.147  43.401  55.342  1.00 123.68 ? 368 GLN A CB  1 
ATOM   1521 C CG  . GLN A 1 387 ? -6.320  43.969  53.940  1.00 129.77 ? 368 GLN A CG  1 
ATOM   1522 C CD  . GLN A 1 387 ? -6.991  43.014  52.984  1.00 134.03 ? 368 GLN A CD  1 
ATOM   1523 O OE1 . GLN A 1 387 ? -6.528  42.791  51.869  1.00 134.99 ? 368 GLN A OE1 1 
ATOM   1524 N NE2 . GLN A 1 387 ? -8.107  42.447  53.414  1.00 131.66 ? 368 GLN A NE2 1 
ATOM   1525 N N   . ALA A 1 388 ? -7.558  43.009  58.415  1.00 103.40 ? 369 ALA A N   1 
ATOM   1526 C CA  . ALA A 1 388 ? -7.442  42.515  59.800  1.00 107.58 ? 369 ALA A CA  1 
ATOM   1527 C C   . ALA A 1 388 ? -6.332  41.486  59.945  1.00 105.16 ? 369 ALA A C   1 
ATOM   1528 O O   . ALA A 1 388 ? -6.077  40.754  59.023  1.00 113.37 ? 369 ALA A O   1 
ATOM   1529 C CB  . ALA A 1 388 ? -8.754  41.921  60.217  1.00 105.23 ? 369 ALA A CB  1 
ATOM   1530 N N   . VAL A 1 389 ? -5.685  41.459  61.094  1.00 100.67 ? 370 VAL A N   1 
ATOM   1531 C CA  . VAL A 1 389 ? -4.636  40.434  61.293  1.00 110.69 ? 370 VAL A CA  1 
ATOM   1532 C C   . VAL A 1 389 ? -5.344  39.132  61.630  1.00 117.04 ? 370 VAL A C   1 
ATOM   1533 O O   . VAL A 1 389 ? -6.260  39.162  62.426  1.00 117.58 ? 370 VAL A O   1 
ATOM   1534 C CB  . VAL A 1 389 ? -3.685  40.840  62.421  1.00 113.43 ? 370 VAL A CB  1 
ATOM   1535 C CG1 . VAL A 1 389 ? -2.866  39.660  62.893  1.00 115.31 ? 370 VAL A CG1 1 
ATOM   1536 C CG2 . VAL A 1 389 ? -2.789  41.979  61.989  1.00 108.68 ? 370 VAL A CG2 1 
ATOM   1537 N N   . PRO A 1 390 ? -4.947  38.003  61.034  1.00 118.03 ? 371 PRO A N   1 
ATOM   1538 C CA  . PRO A 1 390 ? -5.580  36.721  61.297  1.00 117.67 ? 371 PRO A CA  1 
ATOM   1539 C C   . PRO A 1 390 ? -5.321  36.141  62.688  1.00 115.43 ? 371 PRO A C   1 
ATOM   1540 O O   . PRO A 1 390 ? -4.229  36.253  63.164  1.00 114.91 ? 371 PRO A O   1 
ATOM   1541 C CB  . PRO A 1 390 ? -4.877  35.821  60.289  1.00 127.30 ? 371 PRO A CB  1 
ATOM   1542 C CG  . PRO A 1 390 ? -3.540  36.467  60.126  1.00 125.93 ? 371 PRO A CG  1 
ATOM   1543 C CD  . PRO A 1 390 ? -3.880  37.932  60.062  1.00 118.33 ? 371 PRO A CD  1 
ATOM   1544 N N   . LYS A 1 391 ? -6.334  35.463  63.221  1.00 114.78 ? 372 LYS A N   1 
ATOM   1545 C CA  . LYS A 1 391 ? -6.340  34.851  64.574  1.00 117.31 ? 372 LYS A CA  1 
ATOM   1546 C C   . LYS A 1 391 ? -5.018  34.160  64.887  1.00 120.92 ? 372 LYS A C   1 
ATOM   1547 O O   . LYS A 1 391 ? -4.559  34.378  65.997  1.00 124.31 ? 372 LYS A O   1 
ATOM   1548 C CB  . LYS A 1 391 ? -7.504  33.874  64.750  1.00 115.80 ? 372 LYS A CB  1 
ATOM   1549 C CG  . LYS A 1 391 ? -8.897  34.480  64.651  1.00 126.41 ? 372 LYS A CG  1 
ATOM   1550 C CD  . LYS A 1 391 ? -9.835  34.084  65.779  1.00 124.05 ? 372 LYS A CD  1 
ATOM   1551 C CE  . LYS A 1 391 ? -11.219 34.687  65.638  1.00 122.68 ? 372 LYS A CE  1 
ATOM   1552 N NZ  . LYS A 1 391 ? -11.739 35.217  66.920  1.00 115.31 ? 372 LYS A NZ  1 
ATOM   1553 N N   . GLU A 1 392 ? -4.506  33.312  63.986  1.00 130.89 ? 373 GLU A N   1 
ATOM   1554 C CA  . GLU A 1 392 ? -3.222  32.636  64.177  1.00 132.12 ? 373 GLU A CA  1 
ATOM   1555 C C   . GLU A 1 392 ? -2.194  33.603  64.721  1.00 122.60 ? 373 GLU A C   1 
ATOM   1556 O O   . GLU A 1 392 ? -1.509  33.337  65.717  1.00 116.87 ? 373 GLU A O   1 
ATOM   1557 C CB  . GLU A 1 392 ? -2.690  32.126  62.839  1.00 137.21 ? 373 GLU A CB  1 
ATOM   1558 C CG  . GLU A 1 392 ? -1.458  31.245  62.933  1.00 139.62 ? 373 GLU A CG  1 
ATOM   1559 C CD  . GLU A 1 392 ? -0.763  31.145  61.592  1.00 141.86 ? 373 GLU A CD  1 
ATOM   1560 O OE1 . GLU A 1 392 ? -1.118  31.944  60.693  1.00 141.16 ? 373 GLU A OE1 1 
ATOM   1561 O OE2 . GLU A 1 392 ? 0.095   30.250  61.419  1.00 145.79 ? 373 GLU A OE2 1 
ATOM   1562 N N   . LYS A 1 393 ? -2.089  34.735  64.035  1.00 117.93 ? 374 LYS A N   1 
ATOM   1563 C CA  . LYS A 1 393 ? -1.030  35.716  64.174  1.00 119.33 ? 374 LYS A CA  1 
ATOM   1564 C C   . LYS A 1 393 ? -1.248  36.579  65.414  1.00 120.81 ? 374 LYS A C   1 
ATOM   1565 O O   . LYS A 1 393 ? -0.362  36.706  66.275  1.00 112.94 ? 374 LYS A O   1 
ATOM   1566 C CB  . LYS A 1 393 ? -1.026  36.556  62.890  1.00 115.99 ? 374 LYS A CB  1 
ATOM   1567 C CG  . LYS A 1 393 ? -0.767  35.837  61.626  1.00 114.85 ? 374 LYS A CG  1 
ATOM   1568 C CD  . LYS A 1 393 ? 0.611   35.284  61.677  1.00 116.70 ? 374 LYS A CD  1 
ATOM   1569 C CE  . LYS A 1 393 ? 0.944   34.612  60.396  1.00 117.86 ? 374 LYS A CE  1 
ATOM   1570 N NZ  . LYS A 1 393 ? 2.326   34.031  60.455  1.00 109.95 ? 374 LYS A NZ  1 
ATOM   1571 N N   . ASP A 1 394 ? -2.457  37.112  65.501  1.00 119.99 ? 375 ASP A N   1 
ATOM   1572 C CA  . ASP A 1 394 ? -2.889  37.946  66.639  1.00 113.11 ? 375 ASP A CA  1 
ATOM   1573 C C   . ASP A 1 394 ? -2.586  37.181  67.918  1.00 112.60 ? 375 ASP A C   1 
ATOM   1574 O O   . ASP A 1 394 ? -1.872  37.697  68.744  1.00 118.74 ? 375 ASP A O   1 
ATOM   1575 C CB  . ASP A 1 394 ? -4.389  38.183  66.538  1.00 114.89 ? 375 ASP A CB  1 
ATOM   1576 C CG  . ASP A 1 394 ? -4.890  39.290  67.433  1.00 126.21 ? 375 ASP A CG  1 
ATOM   1577 O OD1 . ASP A 1 394 ? -4.197  39.615  68.393  1.00 125.96 ? 375 ASP A OD1 1 
ATOM   1578 O OD2 . ASP A 1 394 ? -5.969  39.804  67.156  1.00 125.83 ? 375 ASP A OD2 1 
ATOM   1579 N N   . GLU A 1 395 ? -3.007  35.933  67.993  1.00 108.95 ? 376 GLU A N   1 
ATOM   1580 C CA  . GLU A 1 395 ? -2.778  35.166  69.235  1.00 112.38 ? 376 GLU A CA  1 
ATOM   1581 C C   . GLU A 1 395 ? -1.299  34.862  69.402  1.00 110.79 ? 376 GLU A C   1 
ATOM   1582 O O   . GLU A 1 395 ? -0.819  34.877  70.515  1.00 108.36 ? 376 GLU A O   1 
ATOM   1583 C CB  . GLU A 1 395 ? -3.450  33.804  69.128  1.00 115.38 ? 376 GLU A CB  1 
ATOM   1584 C CG  . GLU A 1 395 ? -4.929  33.818  69.428  1.00 117.23 ? 376 GLU A CG  1 
ATOM   1585 C CD  . GLU A 1 395 ? -5.475  32.438  69.725  1.00 133.89 ? 376 GLU A CD  1 
ATOM   1586 O OE1 . GLU A 1 395 ? -6.655  32.197  69.444  1.00 140.21 ? 376 GLU A OE1 1 
ATOM   1587 O OE2 . GLU A 1 395 ? -4.710  31.606  70.233  1.00 137.14 ? 376 GLU A OE2 1 
ATOM   1588 N N   . MET A 1 396 ? -0.602  34.586  68.317  1.00 116.96 ? 377 MET A N   1 
ATOM   1589 C CA  . MET A 1 396 ? 0.797   34.158  68.529  1.00 118.29 ? 377 MET A CA  1 
ATOM   1590 C C   . MET A 1 396 ? 1.651   35.355  68.910  1.00 110.23 ? 377 MET A C   1 
ATOM   1591 O O   . MET A 1 396 ? 2.609   35.162  69.637  1.00 106.42 ? 377 MET A O   1 
ATOM   1592 C CB  . MET A 1 396 ? 1.375   33.444  67.303  1.00 123.75 ? 377 MET A CB  1 
ATOM   1593 C CG  . MET A 1 396 ? 1.244   31.924  67.377  1.00 133.25 ? 377 MET A CG  1 
ATOM   1594 S SD  . MET A 1 396 ? 1.693   31.035  65.855  1.00 156.78 ? 377 MET A SD  1 
ATOM   1595 C CE  . MET A 1 396 ? 1.268   29.355  66.306  1.00 124.16 ? 377 MET A CE  1 
ATOM   1596 N N   . VAL A 1 397 ? 1.306   36.547  68.449  1.00 108.09 ? 378 VAL A N   1 
ATOM   1597 C CA  . VAL A 1 397 ? 2.195   37.675  68.830  1.00 105.60 ? 378 VAL A CA  1 
ATOM   1598 C C   . VAL A 1 397 ? 1.813   38.161  70.221  1.00 106.26 ? 378 VAL A C   1 
ATOM   1599 O O   . VAL A 1 397 ? 2.706   38.517  70.969  1.00 107.34 ? 378 VAL A O   1 
ATOM   1600 C CB  . VAL A 1 397 ? 2.192   38.807  67.801  1.00 97.23  ? 378 VAL A CB  1 
ATOM   1601 C CG1 . VAL A 1 397 ? 0.812   39.379  67.617  1.00 109.69 ? 378 VAL A CG1 1 
ATOM   1602 C CG2 . VAL A 1 397 ? 3.135   39.898  68.228  1.00 92.02  ? 378 VAL A CG2 1 
ATOM   1603 N N   . GLU A 1 398 ? 0.537   38.097  70.578  1.00 105.49 ? 379 GLU A N   1 
ATOM   1604 C CA  . GLU A 1 398 ? 0.128   38.566  71.920  1.00 102.23 ? 379 GLU A CA  1 
ATOM   1605 C C   . GLU A 1 398 ? 0.850   37.716  72.949  1.00 102.96 ? 379 GLU A C   1 
ATOM   1606 O O   . GLU A 1 398 ? 1.444   38.272  73.836  1.00 100.93 ? 379 GLU A O   1 
ATOM   1607 C CB  . GLU A 1 398 ? -1.381  38.462  72.114  1.00 100.48 ? 379 GLU A CB  1 
ATOM   1608 C CG  . GLU A 1 398 ? -2.049  39.792  72.376  1.00 107.45 ? 379 GLU A CG  1 
ATOM   1609 C CD  . GLU A 1 398 ? -3.359  39.690  73.129  1.00 111.96 ? 379 GLU A CD  1 
ATOM   1610 O OE1 . GLU A 1 398 ? -3.380  39.038  74.171  1.00 106.40 ? 379 GLU A OE1 1 
ATOM   1611 O OE2 . GLU A 1 398 ? -4.348  40.269  72.669  1.00 113.04 ? 379 GLU A OE2 1 
ATOM   1612 N N   . GLN A 1 399 ? 0.891   36.403  72.767  1.00 104.99 ? 380 GLN A N   1 
ATOM   1613 C CA  . GLN A 1 399 ? 1.583   35.572  73.777  1.00 105.08 ? 380 GLN A CA  1 
ATOM   1614 C C   . GLN A 1 399 ? 3.075   35.876  73.782  1.00 100.66 ? 380 GLN A C   1 
ATOM   1615 O O   . GLN A 1 399 ? 3.659   35.802  74.835  1.00 97.39  ? 380 GLN A O   1 
ATOM   1616 C CB  . GLN A 1 399 ? 1.230   34.098  73.634  1.00 112.43 ? 380 GLN A CB  1 
ATOM   1617 C CG  . GLN A 1 399 ? -0.051  33.738  74.376  1.00 123.00 ? 380 GLN A CG  1 
ATOM   1618 C CD  . GLN A 1 399 ? 0.083   33.701  75.880  1.00 131.76 ? 380 GLN A CD  1 
ATOM   1619 O OE1 . GLN A 1 399 ? 1.086   34.113  76.448  1.00 125.89 ? 380 GLN A OE1 1 
ATOM   1620 N NE2 . GLN A 1 399 ? -0.936  33.188  76.545  1.00 135.56 ? 380 GLN A NE2 1 
ATOM   1621 N N   . GLU A 1 400 ? 3.675   36.204  72.648  1.00 101.86 ? 381 GLU A N   1 
ATOM   1622 C CA  . GLU A 1 400 ? 5.111   36.542  72.703  1.00 100.63 ? 381 GLU A CA  1 
ATOM   1623 C C   . GLU A 1 400 ? 5.235   37.782  73.571  1.00 97.69  ? 381 GLU A C   1 
ATOM   1624 O O   . GLU A 1 400 ? 6.024   37.761  74.511  1.00 95.41  ? 381 GLU A O   1 
ATOM   1625 C CB  . GLU A 1 400 ? 5.614   36.861  71.307  1.00 90.58  ? 381 GLU A CB  1 
ATOM   1626 C CG  . GLU A 1 400 ? 6.952   36.234  70.986  1.00 94.01  ? 381 GLU A CG  1 
ATOM   1627 C CD  . GLU A 1 400 ? 7.409   35.037  71.796  1.00 103.04 ? 381 GLU A CD  1 
ATOM   1628 O OE1 . GLU A 1 400 ? 6.658   34.081  71.904  1.00 102.88 ? 381 GLU A OE1 1 
ATOM   1629 O OE2 . GLU A 1 400 ? 8.529   35.049  72.277  1.00 102.29 ? 381 GLU A OE2 1 
ATOM   1630 N N   . PHE A 1 401 ? 4.414   38.782  73.276  1.00 97.55  ? 382 PHE A N   1 
ATOM   1631 C CA  . PHE A 1 401 ? 4.422   40.065  74.011  1.00 95.51  ? 382 PHE A CA  1 
ATOM   1632 C C   . PHE A 1 401 ? 4.363   39.812  75.507  1.00 93.43  ? 382 PHE A C   1 
ATOM   1633 O O   . PHE A 1 401 ? 5.216   40.278  76.227  1.00 87.62  ? 382 PHE A O   1 
ATOM   1634 C CB  . PHE A 1 401 ? 3.233   40.921  73.601  1.00 95.17  ? 382 PHE A CB  1 
ATOM   1635 C CG  . PHE A 1 401 ? 2.919   42.010  74.585  1.00 98.91  ? 382 PHE A CG  1 
ATOM   1636 C CD1 . PHE A 1 401 ? 3.910   42.848  75.037  1.00 92.71  ? 382 PHE A CD1 1 
ATOM   1637 C CD2 . PHE A 1 401 ? 1.639   42.194  75.052  1.00 97.62  ? 382 PHE A CD2 1 
ATOM   1638 C CE1 . PHE A 1 401 ? 3.627   43.851  75.937  1.00 86.10  ? 382 PHE A CE1 1 
ATOM   1639 C CE2 . PHE A 1 401 ? 1.360   43.193  75.959  1.00 94.22  ? 382 PHE A CE2 1 
ATOM   1640 C CZ  . PHE A 1 401 ? 2.356   44.014  76.401  1.00 89.01  ? 382 PHE A CZ  1 
ATOM   1641 N N   . ASN A 1 402 ? 3.412   39.018  75.957  1.00 90.56  ? 383 ASN A N   1 
ATOM   1642 C CA  . ASN A 1 402 ? 3.370   38.780  77.415  1.00 90.03  ? 383 ASN A CA  1 
ATOM   1643 C C   . ASN A 1 402 ? 4.617   38.015  77.828  1.00 90.43  ? 383 ASN A C   1 
ATOM   1644 O O   . ASN A 1 402 ? 5.167   38.319  78.865  1.00 89.40  ? 383 ASN A O   1 
ATOM   1645 C CB  . ASN A 1 402 ? 2.105   38.042  77.814  1.00 89.12  ? 383 ASN A CB  1 
ATOM   1646 C CG  . ASN A 1 402 ? 0.875   38.847  77.490  1.00 100.81 ? 383 ASN A CG  1 
ATOM   1647 O OD1 . ASN A 1 402 ? 0.148   38.520  76.570  1.00 106.41 ? 383 ASN A OD1 1 
ATOM   1648 N ND2 . ASN A 1 402 ? 0.641   39.906  78.238  1.00 99.11  ? 383 ASN A ND2 1 
ATOM   1649 N N   . ARG A 1 403 ? 5.020   37.040  77.032  1.00 94.61  ? 384 ARG A N   1 
ATOM   1650 C CA  . ARG A 1 403 ? 6.213   36.253  77.385  1.00 98.10  ? 384 ARG A CA  1 
ATOM   1651 C C   . ARG A 1 403 ? 7.387   37.211  77.504  1.00 91.09  ? 384 ARG A C   1 
ATOM   1652 O O   . ARG A 1 403 ? 8.239   36.994  78.335  1.00 86.95  ? 384 ARG A O   1 
ATOM   1653 C CB  . ARG A 1 403 ? 6.414   35.149  76.350  1.00 102.43 ? 384 ARG A CB  1 
ATOM   1654 C CG  . ARG A 1 403 ? 5.560   33.916  76.610  1.00 106.45 ? 384 ARG A CG  1 
ATOM   1655 C CD  . ARG A 1 403 ? 5.235   33.057  75.411  1.00 108.52 ? 384 ARG A CD  1 
ATOM   1656 N NE  . ARG A 1 403 ? 6.439   32.759  74.670  1.00 114.69 ? 384 ARG A NE  1 
ATOM   1657 C CZ  . ARG A 1 403 ? 7.315   31.843  75.029  1.00 122.35 ? 384 ARG A CZ  1 
ATOM   1658 N NH1 . ARG A 1 403 ? 7.120   31.130  76.122  1.00 121.89 ? 384 ARG A NH1 1 
ATOM   1659 N NH2 . ARG A 1 403 ? 8.406   31.644  74.316  1.00 115.93 ? 384 ARG A NH2 1 
ATOM   1660 N N   . LEU A 1 404 ? 7.368   38.272  76.724  1.00 87.12  ? 385 LEU A N   1 
ATOM   1661 C CA  . LEU A 1 404 ? 8.454   39.242  76.754  1.00 86.33  ? 385 LEU A CA  1 
ATOM   1662 C C   . LEU A 1 404 ? 8.442   40.069  78.035  1.00 87.60  ? 385 LEU A C   1 
ATOM   1663 O O   . LEU A 1 404 ? 9.504   40.363  78.598  1.00 87.55  ? 385 LEU A O   1 
ATOM   1664 C CB  . LEU A 1 404 ? 8.351   40.156  75.542  1.00 86.09  ? 385 LEU A CB  1 
ATOM   1665 C CG  . LEU A 1 404 ? 8.899   39.609  74.238  1.00 83.50  ? 385 LEU A CG  1 
ATOM   1666 C CD1 . LEU A 1 404 ? 8.638   40.574  73.096  1.00 75.48  ? 385 LEU A CD1 1 
ATOM   1667 C CD2 . LEU A 1 404 ? 10.373  39.381  74.423  1.00 87.95  ? 385 LEU A CD2 1 
ATOM   1668 N N   . LEU A 1 405 ? 7.264   40.496  78.491  1.00 86.71  ? 386 LEU A N   1 
ATOM   1669 C CA  . LEU A 1 405 ? 7.195   41.160  79.789  1.00 79.04  ? 386 LEU A CA  1 
ATOM   1670 C C   . LEU A 1 405 ? 7.701   40.245  80.896  1.00 83.67  ? 386 LEU A C   1 
ATOM   1671 O O   . LEU A 1 405 ? 8.611   40.624  81.643  1.00 84.78  ? 386 LEU A O   1 
ATOM   1672 C CB  . LEU A 1 405 ? 5.773   41.629  80.084  1.00 77.00  ? 386 LEU A CB  1 
ATOM   1673 C CG  . LEU A 1 405 ? 5.284   42.738  79.160  1.00 81.32  ? 386 LEU A CG  1 
ATOM   1674 C CD1 . LEU A 1 405 ? 3.770   42.745  78.973  1.00 82.14  ? 386 LEU A CD1 1 
ATOM   1675 C CD2 . LEU A 1 405 ? 5.767   44.049  79.706  1.00 79.63  ? 386 LEU A CD2 1 
ATOM   1676 N N   . GLU A 1 406 ? 7.087   39.075  81.005  1.00 81.28  ? 387 GLU A N   1 
ATOM   1677 C CA  . GLU A 1 406 ? 7.452   38.047  82.004  1.00 80.75  ? 387 GLU A CA  1 
ATOM   1678 C C   . GLU A 1 406 ? 8.964   37.899  82.003  1.00 83.07  ? 387 GLU A C   1 
ATOM   1679 O O   . GLU A 1 406 ? 9.545   37.725  83.042  1.00 81.33  ? 387 GLU A O   1 
ATOM   1680 C CB  . GLU A 1 406 ? 6.858   36.729  81.535  1.00 91.70  ? 387 GLU A CB  1 
ATOM   1681 C CG  . GLU A 1 406 ? 6.087   35.977  82.592  1.00 105.18 ? 387 GLU A CG  1 
ATOM   1682 C CD  . GLU A 1 406 ? 5.518   34.659  82.099  1.00 124.74 ? 387 GLU A CD  1 
ATOM   1683 O OE1 . GLU A 1 406 ? 5.934   33.609  82.618  1.00 126.50 ? 387 GLU A OE1 1 
ATOM   1684 O OE2 . GLU A 1 406 ? 4.661   34.689  81.199  1.00 127.16 ? 387 GLU A OE2 1 
ATOM   1685 N N   . ALA A 1 407 ? 9.554   38.164  80.854  1.00 83.51  ? 388 ALA A N   1 
ATOM   1686 C CA  . ALA A 1 407 ? 11.008  38.065  80.670  1.00 80.84  ? 388 ALA A CA  1 
ATOM   1687 C C   . ALA A 1 407 ? 11.678  39.232  81.370  1.00 82.89  ? 388 ALA A C   1 
ATOM   1688 O O   . ALA A 1 407 ? 12.554  39.013  82.179  1.00 87.92  ? 388 ALA A O   1 
ATOM   1689 C CB  . ALA A 1 407 ? 11.277  38.122  79.207  1.00 86.95  ? 388 ALA A CB  1 
ATOM   1690 N N   . THR A 1 408 ? 11.207  40.445  81.123  1.00 83.88  ? 389 THR A N   1 
ATOM   1691 C CA  . THR A 1 408 ? 11.839  41.628  81.746  1.00 82.47  ? 389 THR A CA  1 
ATOM   1692 C C   . THR A 1 408 ? 11.732  41.509  83.255  1.00 79.92  ? 389 THR A C   1 
ATOM   1693 O O   . THR A 1 408 ? 12.703  41.774  83.920  1.00 80.43  ? 389 THR A O   1 
ATOM   1694 C CB  . THR A 1 408 ? 11.184  42.898  81.239  1.00 79.14  ? 389 THR A CB  1 
ATOM   1695 O OG1 . THR A 1 408 ? 9.907   42.775  81.833  1.00 80.73  ? 389 THR A OG1 1 
ATOM   1696 C CG2 . THR A 1 408 ? 11.015  42.882  79.746  1.00 78.91  ? 389 THR A CG2 1 
ATOM   1697 N N   . SER A 1 409 ? 10.586  41.082  83.762  1.00 79.38  ? 390 SER A N   1 
ATOM   1698 C CA  . SER A 1 409 ? 10.436  40.856  85.215  1.00 82.05  ? 390 SER A CA  1 
ATOM   1699 C C   . SER A 1 409 ? 11.528  39.906  85.694  1.00 86.93  ? 390 SER A C   1 
ATOM   1700 O O   . SER A 1 409 ? 12.148  40.193  86.699  1.00 86.28  ? 390 SER A O   1 
ATOM   1701 C CB  . SER A 1 409 ? 9.102   40.305  85.502  1.00 77.80  ? 390 SER A CB  1 
ATOM   1702 O OG  . SER A 1 409 ? 9.124   39.656  86.751  1.00 91.93  ? 390 SER A OG  1 
ATOM   1703 N N   . TYR A 1 410 ? 11.738  38.805  84.986  1.00 85.31  ? 391 TYR A N   1 
ATOM   1704 C CA  . TYR A 1 410 ? 12.813  37.859  85.343  1.00 90.59  ? 391 TYR A CA  1 
ATOM   1705 C C   . TYR A 1 410 ? 14.156  38.574  85.287  1.00 92.72  ? 391 TYR A C   1 
ATOM   1706 O O   . TYR A 1 410 ? 14.959  38.372  86.168  1.00 98.65  ? 391 TYR A O   1 
ATOM   1707 C CB  . TYR A 1 410 ? 12.796  36.680  84.380  1.00 98.90  ? 391 TYR A CB  1 
ATOM   1708 C CG  . TYR A 1 410 ? 13.886  35.671  84.610  1.00 107.97 ? 391 TYR A CG  1 
ATOM   1709 C CD1 . TYR A 1 410 ? 13.673  34.560  85.392  1.00 110.05 ? 391 TYR A CD1 1 
ATOM   1710 C CD2 . TYR A 1 410 ? 15.127  35.825  84.034  1.00 105.20 ? 391 TYR A CD2 1 
ATOM   1711 C CE1 . TYR A 1 410 ? 14.671  33.631  85.605  1.00 113.61 ? 391 TYR A CE1 1 
ATOM   1712 C CE2 . TYR A 1 410 ? 16.136  34.909  84.235  1.00 106.64 ? 391 TYR A CE2 1 
ATOM   1713 C CZ  . TYR A 1 410 ? 15.907  33.810  85.027  1.00 111.58 ? 391 TYR A CZ  1 
ATOM   1714 O OH  . TYR A 1 410 ? 16.898  32.906  85.223  1.00 117.21 ? 391 TYR A OH  1 
ATOM   1715 N N   . LEU A 1 411 ? 14.399  39.395  84.277  1.00 84.20  ? 392 LEU A N   1 
ATOM   1716 C CA  . LEU A 1 411 ? 15.701  40.095  84.236  1.00 88.04  ? 392 LEU A CA  1 
ATOM   1717 C C   . LEU A 1 411 ? 15.827  40.973  85.465  1.00 96.98  ? 392 LEU A C   1 
ATOM   1718 O O   . LEU A 1 411 ? 16.877  41.001  86.070  1.00 101.27 ? 392 LEU A O   1 
ATOM   1719 C CB  . LEU A 1 411 ? 15.704  41.037  83.044  1.00 86.48  ? 392 LEU A CB  1 
ATOM   1720 C CG  . LEU A 1 411 ? 16.428  40.538  81.815  1.00 85.72  ? 392 LEU A CG  1 
ATOM   1721 C CD1 . LEU A 1 411 ? 15.517  39.603  81.069  1.00 90.66  ? 392 LEU A CD1 1 
ATOM   1722 C CD2 . LEU A 1 411 ? 16.771  41.707  80.935  1.00 79.29  ? 392 LEU A CD2 1 
ATOM   1723 N N   . SER A 1 412 ? 14.778  41.713  85.765  1.00 93.43  ? 393 SER A N   1 
ATOM   1724 C CA  . SER A 1 412 ? 14.849  42.643  86.906  1.00 95.88  ? 393 SER A CA  1 
ATOM   1725 C C   . SER A 1 412 ? 15.051  41.904  88.222  1.00 99.49  ? 393 SER A C   1 
ATOM   1726 O O   . SER A 1 412 ? 15.973  42.238  88.924  1.00 97.57  ? 393 SER A O   1 
ATOM   1727 C CB  . SER A 1 412 ? 13.624  43.471  86.962  1.00 92.33  ? 393 SER A CB  1 
ATOM   1728 O OG  . SER A 1 412 ? 13.522  44.053  88.237  1.00 95.95  ? 393 SER A OG  1 
ATOM   1729 N N   . HIS A 1 413 ? 14.225  40.916  88.526  1.00 98.52  ? 394 HIS A N   1 
ATOM   1730 C CA  . HIS A 1 413 ? 14.321  40.308  89.875  1.00 104.79 ? 394 HIS A CA  1 
ATOM   1731 C C   . HIS A 1 413 ? 15.380  39.223  90.021  1.00 108.28 ? 394 HIS A C   1 
ATOM   1732 O O   . HIS A 1 413 ? 16.107  39.286  91.005  1.00 110.90 ? 394 HIS A O   1 
ATOM   1733 C CB  . HIS A 1 413 ? 12.954  39.824  90.331  1.00 101.98 ? 394 HIS A CB  1 
ATOM   1734 C CG  . HIS A 1 413 ? 12.005  40.953  90.421  1.00 105.80 ? 394 HIS A CG  1 
ATOM   1735 N ND1 . HIS A 1 413 ? 10.910  41.045  89.618  1.00 109.64 ? 394 HIS A ND1 1 
ATOM   1736 C CD2 . HIS A 1 413 ? 12.016  42.060  91.180  1.00 106.12 ? 394 HIS A CD2 1 
ATOM   1737 C CE1 . HIS A 1 413 ? 10.262  42.152  89.887  1.00 108.59 ? 394 HIS A CE1 1 
ATOM   1738 N NE2 . HIS A 1 413 ? 10.920  42.789  90.837  1.00 110.15 ? 394 HIS A NE2 1 
ATOM   1739 N N   . GLN A 1 414 ? 15.452  38.259  89.116  1.00 108.70 ? 395 GLN A N   1 
ATOM   1740 C CA  . GLN A 1 414 ? 16.420  37.170  89.370  1.00 110.45 ? 395 GLN A CA  1 
ATOM   1741 C C   . GLN A 1 414 ? 17.816  37.531  88.882  1.00 105.46 ? 395 GLN A C   1 
ATOM   1742 O O   . GLN A 1 414 ? 18.759  37.038  89.465  1.00 112.70 ? 395 GLN A O   1 
ATOM   1743 C CB  . GLN A 1 414 ? 15.918  35.841  88.820  1.00 112.29 ? 395 GLN A CB  1 
ATOM   1744 C CG  . GLN A 1 414 ? 15.106  35.049  89.827  1.00 118.61 ? 395 GLN A CG  1 
ATOM   1745 C CD  . GLN A 1 414 ? 13.669  35.497  89.814  1.00 125.23 ? 395 GLN A CD  1 
ATOM   1746 O OE1 . GLN A 1 414 ? 13.375  36.682  89.766  1.00 119.70 ? 395 GLN A OE1 1 
ATOM   1747 N NE2 . GLN A 1 414 ? 12.754  34.546  89.848  1.00 135.05 ? 395 GLN A NE2 1 
ATOM   1748 N N   . LEU A 1 415 ? 17.951  38.375  87.876  1.00 98.78  ? 396 LEU A N   1 
ATOM   1749 C CA  . LEU A 1 415 ? 19.328  38.667  87.422  1.00 103.94 ? 396 LEU A CA  1 
ATOM   1750 C C   . LEU A 1 415 ? 19.770  40.041  87.906  1.00 109.10 ? 396 LEU A C   1 
ATOM   1751 O O   . LEU A 1 415 ? 20.906  40.419  87.635  1.00 105.45 ? 396 LEU A O   1 
ATOM   1752 C CB  . LEU A 1 415 ? 19.337  38.601  85.903  1.00 105.88 ? 396 LEU A CB  1 
ATOM   1753 C CG  . LEU A 1 415 ? 18.694  37.342  85.348  1.00 106.70 ? 396 LEU A CG  1 
ATOM   1754 C CD1 . LEU A 1 415 ? 18.905  37.243  83.855  1.00 100.56 ? 396 LEU A CD1 1 
ATOM   1755 C CD2 . LEU A 1 415 ? 19.264  36.130  86.041  1.00 104.66 ? 396 LEU A CD2 1 
ATOM   1756 N N   . ASP A 1 416 ? 18.876  40.768  88.563  1.00 113.36 ? 397 ASP A N   1 
ATOM   1757 C CA  . ASP A 1 416 ? 19.170  42.128  89.080  1.00 109.92 ? 397 ASP A CA  1 
ATOM   1758 C C   . ASP A 1 416 ? 19.762  42.992  87.974  1.00 106.29 ? 397 ASP A C   1 
ATOM   1759 O O   . ASP A 1 416 ? 20.753  43.651  88.216  1.00 109.29 ? 397 ASP A O   1 
ATOM   1760 C CB  . ASP A 1 416 ? 20.013  42.133  90.351  1.00 108.94 ? 397 ASP A CB  1 
ATOM   1761 C CG  . ASP A 1 416 ? 19.930  43.472  91.056  1.00 121.37 ? 397 ASP A CG  1 
ATOM   1762 O OD1 . ASP A 1 416 ? 20.656  44.384  90.653  1.00 119.54 ? 397 ASP A OD1 1 
ATOM   1763 O OD2 . ASP A 1 416 ? 19.114  43.602  91.980  1.00 126.66 ? 397 ASP A OD2 1 
ATOM   1764 N N   . PHE A 1 417 ? 19.128  43.013  86.814  1.00 99.75  ? 398 PHE A N   1 
ATOM   1765 C CA  . PHE A 1 417 ? 19.611  43.851  85.702  1.00 100.23 ? 398 PHE A CA  1 
ATOM   1766 C C   . PHE A 1 417 ? 18.926  45.194  85.878  1.00 99.35  ? 398 PHE A C   1 
ATOM   1767 O O   . PHE A 1 417 ? 17.999  45.470  85.152  1.00 99.23  ? 398 PHE A O   1 
ATOM   1768 C CB  . PHE A 1 417 ? 19.140  43.216  84.400  1.00 95.35  ? 398 PHE A CB  1 
ATOM   1769 C CG  . PHE A 1 417 ? 19.514  43.963  83.155  1.00 87.27  ? 398 PHE A CG  1 
ATOM   1770 C CD1 . PHE A 1 417 ? 20.818  44.328  82.918  1.00 90.69  ? 398 PHE A CD1 1 
ATOM   1771 C CD2 . PHE A 1 417 ? 18.562  44.291  82.221  1.00 82.43  ? 398 PHE A CD2 1 
ATOM   1772 C CE1 . PHE A 1 417 ? 21.161  45.015  81.772  1.00 88.20  ? 398 PHE A CE1 1 
ATOM   1773 C CE2 . PHE A 1 417 ? 18.907  44.978  81.077  1.00 85.51  ? 398 PHE A CE2 1 
ATOM   1774 C CZ  . PHE A 1 417 ? 20.203  45.341  80.859  1.00 84.22  ? 398 PHE A CZ  1 
ATOM   1775 N N   . ASN A 1 418 ? 19.366  45.994  86.838  1.00 101.33 ? 399 ASN A N   1 
ATOM   1776 C CA  . ASN A 1 418 ? 18.615  47.241  87.104  1.00 98.43  ? 399 ASN A CA  1 
ATOM   1777 C C   . ASN A 1 418 ? 19.476  48.464  86.870  1.00 97.39  ? 399 ASN A C   1 
ATOM   1778 O O   . ASN A 1 418 ? 18.916  49.515  86.659  1.00 98.19  ? 399 ASN A O   1 
ATOM   1779 C CB  . ASN A 1 418 ? 18.005  47.194  88.490  1.00 99.87  ? 399 ASN A CB  1 
ATOM   1780 C CG  . ASN A 1 418 ? 17.040  46.045  88.562  1.00 98.89  ? 399 ASN A CG  1 
ATOM   1781 O OD1 . ASN A 1 418 ? 16.187  45.923  87.706  1.00 93.47  ? 399 ASN A OD1 1 
ATOM   1782 N ND2 . ASN A 1 418 ? 17.223  45.167  89.523  1.00 103.00 ? 399 ASN A ND2 1 
ATOM   1783 N N   . VAL A 1 419 ? 20.784  48.328  86.950  1.00 101.14 ? 400 VAL A N   1 
ATOM   1784 C CA  . VAL A 1 419 ? 21.597  49.497  86.633  1.00 100.38 ? 400 VAL A CA  1 
ATOM   1785 C C   . VAL A 1 419 ? 22.509  49.124  85.471  1.00 105.70 ? 400 VAL A C   1 
ATOM   1786 O O   . VAL A 1 419 ? 22.989  47.989  85.394  1.00 112.44 ? 400 VAL A O   1 
ATOM   1787 C CB  . VAL A 1 419 ? 22.420  49.977  87.847  1.00 105.37 ? 400 VAL A CB  1 
ATOM   1788 C CG1 . VAL A 1 419 ? 23.025  51.347  87.568  1.00 107.37 ? 400 VAL A CG1 1 
ATOM   1789 C CG2 . VAL A 1 419 ? 21.572  50.010  89.120  1.00 100.17 ? 400 VAL A CG2 1 
ATOM   1790 N N   . LEU A 1 420 ? 22.750  50.071  84.561  1.00 107.11 ? 401 LEU A N   1 
ATOM   1791 C CA  . LEU A 1 420 ? 23.588  49.791  83.395  1.00 110.53 ? 401 LEU A CA  1 
ATOM   1792 C C   . LEU A 1 420 ? 24.309  51.077  83.026  1.00 114.57 ? 401 LEU A C   1 
ATOM   1793 O O   . LEU A 1 420 ? 23.647  52.033  82.609  1.00 114.21 ? 401 LEU A O   1 
ATOM   1794 C CB  . LEU A 1 420 ? 22.752  49.355  82.198  1.00 108.10 ? 401 LEU A CB  1 
ATOM   1795 C CG  . LEU A 1 420 ? 23.485  48.569  81.104  1.00 115.33 ? 401 LEU A CG  1 
ATOM   1796 C CD1 . LEU A 1 420 ? 22.487  47.948  80.093  1.00 112.33 ? 401 LEU A CD1 1 
ATOM   1797 C CD2 . LEU A 1 420 ? 24.745  49.170  80.447  1.00 124.44 ? 401 LEU A CD2 1 
ATOM   1798 N N   . ASN A 1 421 ? 25.640  51.093  83.099  1.00 118.50 ? 402 ASN A N   1 
ATOM   1799 C CA  . ASN A 1 421 ? 26.408  52.296  82.756  1.00 122.71 ? 402 ASN A CA  1 
ATOM   1800 C C   . ASN A 1 421 ? 26.078  53.429  83.719  1.00 119.81 ? 402 ASN A C   1 
ATOM   1801 O O   . ASN A 1 421 ? 25.932  54.589  83.314  1.00 117.44 ? 402 ASN A O   1 
ATOM   1802 C CB  . ASN A 1 421 ? 26.164  52.756  81.310  1.00 122.71 ? 402 ASN A CB  1 
ATOM   1803 C CG  . ASN A 1 421 ? 26.759  51.818  80.274  1.00 132.47 ? 402 ASN A CG  1 
ATOM   1804 O OD1 . ASN A 1 421 ? 27.335  50.773  80.607  1.00 133.72 ? 402 ASN A OD1 1 
ATOM   1805 N ND2 . ASN A 1 421 ? 26.610  52.181  79.000  1.00 133.99 ? 402 ASN A ND2 1 
ATOM   1806 N N   . ASN A 1 422 ? 25.922  53.075  84.998  1.00 115.74 ? 403 ASN A N   1 
ATOM   1807 C CA  . ASN A 1 422 ? 25.650  54.027  86.078  1.00 117.95 ? 403 ASN A CA  1 
ATOM   1808 C C   . ASN A 1 422 ? 24.310  54.736  85.893  1.00 115.19 ? 403 ASN A C   1 
ATOM   1809 O O   . ASN A 1 422 ? 24.142  55.883  86.314  1.00 119.64 ? 403 ASN A O   1 
ATOM   1810 C CB  . ASN A 1 422 ? 26.778  55.058  86.219  1.00 122.12 ? 403 ASN A CB  1 
ATOM   1811 C CG  . ASN A 1 422 ? 28.137  54.414  86.463  1.00 130.64 ? 403 ASN A CG  1 
ATOM   1812 O OD1 . ASN A 1 422 ? 28.468  54.045  87.596  1.00 132.83 ? 403 ASN A OD1 1 
ATOM   1813 N ND2 . ASN A 1 422 ? 28.936  54.287  85.400  1.00 127.76 ? 403 ASN A ND2 1 
ATOM   1814 N N   . LYS A 1 423 ? 23.343  54.075  85.265  1.00 108.70 ? 404 LYS A N   1 
ATOM   1815 C CA  . LYS A 1 423 ? 22.038  54.665  85.013  1.00 97.39  ? 404 LYS A CA  1 
ATOM   1816 C C   . LYS A 1 423 ? 20.964  53.614  85.251  1.00 94.30  ? 404 LYS A C   1 
ATOM   1817 O O   . LYS A 1 423 ? 21.221  52.416  85.092  1.00 97.17  ? 404 LYS A O   1 
ATOM   1818 C CB  . LYS A 1 423 ? 21.940  55.211  83.580  1.00 96.19  ? 404 LYS A CB  1 
ATOM   1819 C CG  . LYS A 1 423 ? 22.981  56.280  83.265  1.00 101.84 ? 404 LYS A CG  1 
ATOM   1820 C CD  . LYS A 1 423 ? 22.587  57.129  82.064  1.00 104.62 ? 404 LYS A CD  1 
ATOM   1821 C CE  . LYS A 1 423 ? 22.856  56.411  80.740  1.00 107.12 ? 404 LYS A CE  1 
ATOM   1822 N NZ  . LYS A 1 423 ? 22.440  57.216  79.548  1.00 93.68  ? 404 LYS A NZ  1 
ATOM   1823 N N   . PRO A 1 424 ? 19.769  54.023  85.657  1.00 89.38  ? 405 PRO A N   1 
ATOM   1824 C CA  . PRO A 1 424 ? 18.711  53.040  85.881  1.00 88.25  ? 405 PRO A CA  1 
ATOM   1825 C C   . PRO A 1 424 ? 18.221  52.469  84.565  1.00 84.68  ? 405 PRO A C   1 
ATOM   1826 O O   . PRO A 1 424 ? 18.160  53.150  83.538  1.00 85.19  ? 405 PRO A O   1 
ATOM   1827 C CB  . PRO A 1 424 ? 17.618  53.850  86.584  1.00 83.84  ? 405 PRO A CB  1 
ATOM   1828 C CG  . PRO A 1 424 ? 17.800  55.212  86.051  1.00 84.87  ? 405 PRO A CG  1 
ATOM   1829 C CD  . PRO A 1 424 ? 19.301  55.387  85.934  1.00 90.34  ? 405 PRO A CD  1 
ATOM   1830 N N   . VAL A 1 425 ? 17.866  51.202  84.603  1.00 80.58  ? 406 VAL A N   1 
ATOM   1831 C CA  . VAL A 1 425 ? 17.502  50.501  83.384  1.00 81.56  ? 406 VAL A CA  1 
ATOM   1832 C C   . VAL A 1 425 ? 16.045  50.792  83.074  1.00 77.46  ? 406 VAL A C   1 
ATOM   1833 O O   . VAL A 1 425 ? 15.169  50.588  83.922  1.00 75.64  ? 406 VAL A O   1 
ATOM   1834 C CB  . VAL A 1 425 ? 17.745  48.996  83.543  1.00 84.85  ? 406 VAL A CB  1 
ATOM   1835 C CG1 . VAL A 1 425 ? 17.299  48.273  82.290  1.00 78.74  ? 406 VAL A CG1 1 
ATOM   1836 C CG2 . VAL A 1 425 ? 19.225  48.724  83.915  1.00 92.04  ? 406 VAL A CG2 1 
ATOM   1837 N N   . SER A 1 426 ? 15.770  51.266  81.864  1.00 72.81  ? 407 SER A N   1 
ATOM   1838 C CA  . SER A 1 426 ? 14.358  51.468  81.603  1.00 76.85  ? 407 SER A CA  1 
ATOM   1839 C C   . SER A 1 426 ? 13.687  50.138  81.275  1.00 76.99  ? 407 SER A C   1 
ATOM   1840 O O   . SER A 1 426 ? 14.336  49.108  81.091  1.00 81.06  ? 407 SER A O   1 
ATOM   1841 C CB  . SER A 1 426 ? 14.132  52.470  80.483  1.00 75.62  ? 407 SER A CB  1 
ATOM   1842 O OG  . SER A 1 426 ? 14.388  51.905  79.231  1.00 78.60  ? 407 SER A OG  1 
ATOM   1843 N N   . LEU A 1 427 ? 12.355  50.151  81.253  1.00 75.75  ? 408 LEU A N   1 
ATOM   1844 C CA  . LEU A 1 427 ? 11.644  48.970  80.789  1.00 72.43  ? 408 LEU A CA  1 
ATOM   1845 C C   . LEU A 1 427 ? 11.944  48.731  79.322  1.00 75.32  ? 408 LEU A C   1 
ATOM   1846 O O   . LEU A 1 427 ? 12.282  47.611  78.924  1.00 79.24  ? 408 LEU A O   1 
ATOM   1847 C CB  . LEU A 1 427 ? 10.142  49.121  81.008  1.00 70.18  ? 408 LEU A CB  1 
ATOM   1848 C CG  . LEU A 1 427 ? 9.335   47.991  80.388  1.00 63.28  ? 408 LEU A CG  1 
ATOM   1849 C CD1 . LEU A 1 427 ? 9.714   46.752  81.087  1.00 67.03  ? 408 LEU A CD1 1 
ATOM   1850 C CD2 . LEU A 1 427 ? 7.847   48.207  80.504  1.00 63.53  ? 408 LEU A CD2 1 
ATOM   1851 N N   . GLY A 1 428 ? 11.854  49.789  78.510  1.00 71.19  ? 409 GLY A N   1 
ATOM   1852 C CA  . GLY A 1 428 ? 12.141  49.654  77.092  1.00 72.01  ? 409 GLY A CA  1 
ATOM   1853 C C   . GLY A 1 428 ? 13.549  49.164  76.814  1.00 73.58  ? 409 GLY A C   1 
ATOM   1854 O O   . GLY A 1 428 ? 13.755  48.311  75.951  1.00 76.49  ? 409 GLY A O   1 
ATOM   1855 N N   . GLN A 1 429 ? 14.536  49.701  77.534  1.00 71.51  ? 410 GLN A N   1 
ATOM   1856 C CA  . GLN A 1 429 ? 15.897  49.191  77.432  1.00 71.94  ? 410 GLN A CA  1 
ATOM   1857 C C   . GLN A 1 429 ? 15.898  47.684  77.503  1.00 78.34  ? 410 GLN A C   1 
ATOM   1858 O O   . GLN A 1 429 ? 16.414  47.007  76.611  1.00 88.02  ? 410 GLN A O   1 
ATOM   1859 C CB  . GLN A 1 429 ? 16.747  49.744  78.560  1.00 73.71  ? 410 GLN A CB  1 
ATOM   1860 C CG  . GLN A 1 429 ? 17.449  51.024  78.261  1.00 81.55  ? 410 GLN A CG  1 
ATOM   1861 C CD  . GLN A 1 429 ? 18.466  51.317  79.320  1.00 91.09  ? 410 GLN A CD  1 
ATOM   1862 O OE1 . GLN A 1 429 ? 19.133  50.399  79.818  1.00 89.35  ? 410 GLN A OE1 1 
ATOM   1863 N NE2 . GLN A 1 429 ? 18.574  52.591  79.711  1.00 98.50  ? 410 GLN A NE2 1 
ATOM   1864 N N   . ALA A 1 430 ? 15.275  47.142  78.552  1.00 78.93  ? 411 ALA A N   1 
ATOM   1865 C CA  . ALA A 1 430 ? 15.275  45.709  78.789  1.00 76.38  ? 411 ALA A CA  1 
ATOM   1866 C C   . ALA A 1 430 ? 14.381  44.948  77.830  1.00 75.27  ? 411 ALA A C   1 
ATOM   1867 O O   . ALA A 1 430 ? 14.538  43.741  77.699  1.00 82.65  ? 411 ALA A O   1 
ATOM   1868 C CB  . ALA A 1 430 ? 14.847  45.412  80.216  1.00 78.44  ? 411 ALA A CB  1 
ATOM   1869 N N   . LEU A 1 431 ? 13.440  45.595  77.163  1.00 77.60  ? 412 LEU A N   1 
ATOM   1870 C CA  . LEU A 1 431 ? 12.749  44.874  76.101  1.00 82.54  ? 412 LEU A CA  1 
ATOM   1871 C C   . LEU A 1 431 ? 13.652  44.697  74.885  1.00 88.44  ? 412 LEU A C   1 
ATOM   1872 O O   . LEU A 1 431 ? 13.660  43.628  74.258  1.00 89.35  ? 412 LEU A O   1 
ATOM   1873 C CB  . LEU A 1 431 ? 11.459  45.580  75.714  1.00 78.00  ? 412 LEU A CB  1 
ATOM   1874 C CG  . LEU A 1 431 ? 10.342  45.311  76.708  1.00 76.31  ? 412 LEU A CG  1 
ATOM   1875 C CD1 . LEU A 1 431 ? 9.069   45.793  76.131  1.00 82.95  ? 412 LEU A CD1 1 
ATOM   1876 C CD2 . LEU A 1 431 ? 10.239  43.861  76.953  1.00 78.93  ? 412 LEU A CD2 1 
ATOM   1877 N N   . GLU A 1 432 ? 14.416  45.729  74.529  1.00 87.13  ? 413 GLU A N   1 
ATOM   1878 C CA  . GLU A 1 432 ? 15.445  45.552  73.518  1.00 87.16  ? 413 GLU A CA  1 
ATOM   1879 C C   . GLU A 1 432 ? 16.351  44.378  73.878  1.00 90.77  ? 413 GLU A C   1 
ATOM   1880 O O   . GLU A 1 432 ? 16.514  43.431  73.097  1.00 93.56  ? 413 GLU A O   1 
ATOM   1881 C CB  . GLU A 1 432 ? 16.239  46.843  73.374  1.00 88.22  ? 413 GLU A CB  1 
ATOM   1882 C CG  . GLU A 1 432 ? 15.591  47.859  72.438  1.00 100.43 ? 413 GLU A CG  1 
ATOM   1883 C CD  . GLU A 1 432 ? 16.260  49.234  72.531  1.00 115.57 ? 413 GLU A CD  1 
ATOM   1884 O OE1 . GLU A 1 432 ? 17.196  49.384  73.361  1.00 111.97 ? 413 GLU A OE1 1 
ATOM   1885 O OE2 . GLU A 1 432 ? 15.856  50.162  71.781  1.00 124.63 ? 413 GLU A OE2 1 
ATOM   1886 N N   . VAL A 1 433 ? 16.924  44.462  75.058  1.00 82.89  ? 414 VAL A N   1 
ATOM   1887 C CA  . VAL A 1 433 ? 17.890  43.423  75.466  1.00 86.91  ? 414 VAL A CA  1 
ATOM   1888 C C   . VAL A 1 433 ? 17.214  42.070  75.486  1.00 91.40  ? 414 VAL A C   1 
ATOM   1889 O O   . VAL A 1 433 ? 17.911  41.092  75.434  1.00 98.39  ? 414 VAL A O   1 
ATOM   1890 C CB  . VAL A 1 433 ? 18.463  43.740  76.843  1.00 83.66  ? 414 VAL A CB  1 
ATOM   1891 C CG1 . VAL A 1 433 ? 18.897  42.475  77.530  1.00 86.27  ? 414 VAL A CG1 1 
ATOM   1892 C CG2 . VAL A 1 433 ? 19.619  44.700  76.731  1.00 82.94  ? 414 VAL A CG2 1 
ATOM   1893 N N   . VAL A 1 434 ? 15.902  42.010  75.579  1.00 89.63  ? 415 VAL A N   1 
ATOM   1894 C CA  . VAL A 1 434 ? 15.324  40.645  75.649  1.00 88.67  ? 415 VAL A CA  1 
ATOM   1895 C C   . VAL A 1 434 ? 15.036  40.220  74.231  1.00 87.69  ? 415 VAL A C   1 
ATOM   1896 O O   . VAL A 1 434 ? 15.254  39.083  73.903  1.00 90.62  ? 415 VAL A O   1 
ATOM   1897 C CB  . VAL A 1 434 ? 14.059  40.599  76.505  1.00 82.12  ? 415 VAL A CB  1 
ATOM   1898 C CG1 . VAL A 1 434 ? 13.110  39.550  75.986  1.00 82.75  ? 415 VAL A CG1 1 
ATOM   1899 C CG2 . VAL A 1 434 ? 14.401  40.316  77.942  1.00 78.25  ? 415 VAL A CG2 1 
ATOM   1900 N N   . ILE A 1 435 ? 14.600  41.153  73.411  1.00 87.96  ? 416 ILE A N   1 
ATOM   1901 C CA  . ILE A 1 435 ? 14.319  40.759  72.013  1.00 88.12  ? 416 ILE A CA  1 
ATOM   1902 C C   . ILE A 1 435 ? 15.641  40.373  71.381  1.00 91.05  ? 416 ILE A C   1 
ATOM   1903 O O   . ILE A 1 435 ? 15.681  39.383  70.704  1.00 94.32  ? 416 ILE A O   1 
ATOM   1904 C CB  . ILE A 1 435 ? 13.686  41.921  71.266  1.00 82.05  ? 416 ILE A CB  1 
ATOM   1905 C CG1 . ILE A 1 435 ? 12.217  42.055  71.637  1.00 80.54  ? 416 ILE A CG1 1 
ATOM   1906 C CG2 . ILE A 1 435 ? 13.867  41.713  69.789  1.00 82.77  ? 416 ILE A CG2 1 
ATOM   1907 C CD1 . ILE A 1 435 ? 11.521  43.123  70.877  1.00 83.70  ? 416 ILE A CD1 1 
ATOM   1908 N N   . GLN A 1 436 ? 16.677  41.163  71.607  1.00 94.74  ? 417 GLN A N   1 
ATOM   1909 C CA  . GLN A 1 436 ? 18.000  40.831  71.047  1.00 95.45  ? 417 GLN A CA  1 
ATOM   1910 C C   . GLN A 1 436 ? 18.387  39.439  71.518  1.00 94.21  ? 417 GLN A C   1 
ATOM   1911 O O   . GLN A 1 436 ? 18.611  38.595  70.686  1.00 101.16 ? 417 GLN A O   1 
ATOM   1912 C CB  . GLN A 1 436 ? 19.008  41.888  71.469  1.00 94.33  ? 417 GLN A CB  1 
ATOM   1913 C CG  . GLN A 1 436 ? 18.746  43.214  70.791  1.00 97.88  ? 417 GLN A CG  1 
ATOM   1914 C CD  . GLN A 1 436 ? 19.602  44.309  71.358  1.00 104.30 ? 417 GLN A CD  1 
ATOM   1915 O OE1 . GLN A 1 436 ? 20.321  44.117  72.323  1.00 101.48 ? 417 GLN A OE1 1 
ATOM   1916 N NE2 . GLN A 1 436 ? 19.526  45.474  70.750  1.00 106.62 ? 417 GLN A NE2 1 
ATOM   1917 N N   . LEU A 1 437 ? 18.293  39.159  72.806  1.00 88.63  ? 418 LEU A N   1 
ATOM   1918 C CA  . LEU A 1 437 ? 18.696  37.817  73.280  1.00 92.64  ? 418 LEU A CA  1 
ATOM   1919 C C   . LEU A 1 437 ? 17.834  36.721  72.663  1.00 95.89  ? 418 LEU A C   1 
ATOM   1920 O O   . LEU A 1 437 ? 18.350  35.658  72.446  1.00 96.65  ? 418 LEU A O   1 
ATOM   1921 C CB  . LEU A 1 437 ? 18.646  37.775  74.798  1.00 92.90  ? 418 LEU A CB  1 
ATOM   1922 C CG  . LEU A 1 437 ? 20.014  37.617  75.438  1.00 98.63  ? 418 LEU A CG  1 
ATOM   1923 C CD1 . LEU A 1 437 ? 21.039  38.353  74.620  1.00 106.56 ? 418 LEU A CD1 1 
ATOM   1924 C CD2 . LEU A 1 437 ? 20.014  38.153  76.848  1.00 104.66 ? 418 LEU A CD2 1 
ATOM   1925 N N   . GLN A 1 438 ? 16.556  36.957  72.409  1.00 93.23  ? 419 GLN A N   1 
ATOM   1926 C CA  . GLN A 1 438 ? 15.757  35.909  71.746  1.00 92.12  ? 419 GLN A CA  1 
ATOM   1927 C C   . GLN A 1 438 ? 16.185  35.851  70.288  1.00 99.44  ? 419 GLN A C   1 
ATOM   1928 O O   . GLN A 1 438 ? 16.166  34.785  69.726  1.00 104.21 ? 419 GLN A O   1 
ATOM   1929 C CB  . GLN A 1 438 ? 14.279  36.198  71.915  1.00 88.62  ? 419 GLN A CB  1 
ATOM   1930 C CG  . GLN A 1 438 ? 13.889  36.129  73.369  1.00 90.60  ? 419 GLN A CG  1 
ATOM   1931 C CD  . GLN A 1 438 ? 14.297  34.810  73.957  1.00 99.44  ? 419 GLN A CD  1 
ATOM   1932 O OE1 . GLN A 1 438 ? 15.158  34.718  74.819  1.00 94.05  ? 419 GLN A OE1 1 
ATOM   1933 N NE2 . GLN A 1 438 ? 13.645  33.767  73.491  1.00 103.73 ? 419 GLN A NE2 1 
ATOM   1934 N N   . GLU A 1 439 ? 16.575  36.973  69.704  1.00 100.88 ? 420 GLU A N   1 
ATOM   1935 C CA  . GLU A 1 439 ? 17.048  36.925  68.304  1.00 99.61  ? 420 GLU A CA  1 
ATOM   1936 C C   . GLU A 1 439 ? 18.380  36.185  68.284  1.00 98.91  ? 420 GLU A C   1 
ATOM   1937 O O   . GLU A 1 439 ? 18.618  35.444  67.360  1.00 101.41 ? 420 GLU A O   1 
ATOM   1938 C CB  . GLU A 1 439 ? 17.184  38.336  67.745  1.00 97.94  ? 420 GLU A CB  1 
ATOM   1939 C CG  . GLU A 1 439 ? 16.113  38.663  66.733  1.00 104.93 ? 420 GLU A CG  1 
ATOM   1940 C CD  . GLU A 1 439 ? 15.889  40.138  66.506  1.00 107.59 ? 420 GLU A CD  1 
ATOM   1941 O OE1 . GLU A 1 439 ? 16.657  40.923  67.049  1.00 103.82 ? 420 GLU A OE1 1 
ATOM   1942 O OE2 . GLU A 1 439 ? 14.949  40.486  65.787  1.00 110.77 ? 420 GLU A OE2 1 
ATOM   1943 N N   . LYS A 1 440 ? 19.219  36.388  69.286  1.00 97.87  ? 421 LYS A N   1 
ATOM   1944 C CA  . LYS A 1 440 ? 20.500  35.662  69.281  1.00 96.06  ? 421 LYS A CA  1 
ATOM   1945 C C   . LYS A 1 440 ? 20.202  34.176  69.334  1.00 98.36  ? 421 LYS A C   1 
ATOM   1946 O O   . LYS A 1 440 ? 20.739  33.460  68.532  1.00 105.87 ? 421 LYS A O   1 
ATOM   1947 C CB  . LYS A 1 440 ? 21.345  36.024  70.496  1.00 91.35  ? 421 LYS A CB  1 
ATOM   1948 C CG  . LYS A 1 440 ? 22.255  34.912  70.978  1.00 89.18  ? 421 LYS A CG  1 
ATOM   1949 C CD  . LYS A 1 440 ? 23.285  35.370  71.953  1.00 90.46  ? 421 LYS A CD  1 
ATOM   1950 C CE  . LYS A 1 440 ? 24.223  34.255  72.345  1.00 106.40 ? 421 LYS A CE  1 
ATOM   1951 N NZ  . LYS A 1 440 ? 24.384  34.147  73.812  1.00 114.95 ? 421 LYS A NZ  1 
ATOM   1952 N N   . HIS A 1 441 ? 19.323  33.754  70.224  1.00 100.13 ? 422 HIS A N   1 
ATOM   1953 C CA  . HIS A 1 441 ? 19.037  32.308  70.348  1.00 103.33 ? 422 HIS A CA  1 
ATOM   1954 C C   . HIS A 1 441 ? 18.562  31.736  69.022  1.00 100.86 ? 422 HIS A C   1 
ATOM   1955 O O   . HIS A 1 441 ? 18.963  30.642  68.731  1.00 107.59 ? 422 HIS A O   1 
ATOM   1956 C CB  . HIS A 1 441 ? 18.051  32.050  71.467  1.00 105.46 ? 422 HIS A CB  1 
ATOM   1957 C CG  . HIS A 1 441 ? 17.612  30.638  71.537  1.00 108.09 ? 422 HIS A CG  1 
ATOM   1958 N ND1 . HIS A 1 441 ? 16.473  30.206  70.926  1.00 111.03 ? 422 HIS A ND1 1 
ATOM   1959 C CD2 . HIS A 1 441 ? 18.142  29.575  72.159  1.00 107.68 ? 422 HIS A CD2 1 
ATOM   1960 C CE1 . HIS A 1 441 ? 16.309  28.932  71.166  1.00 111.18 ? 422 HIS A CE1 1 
ATOM   1961 N NE2 . HIS A 1 441 ? 17.314  28.525  71.919  1.00 112.71 ? 422 HIS A NE2 1 
ATOM   1962 N N   . VAL A 1 442 ? 17.712  32.439  68.289  1.00 97.54  ? 423 VAL A N   1 
ATOM   1963 C CA  . VAL A 1 442 ? 17.319  31.955  66.961  1.00 98.50  ? 423 VAL A CA  1 
ATOM   1964 C C   . VAL A 1 442 ? 18.543  31.613  66.126  1.00 106.17 ? 423 VAL A C   1 
ATOM   1965 O O   . VAL A 1 442 ? 18.638  30.527  65.536  1.00 105.97 ? 423 VAL A O   1 
ATOM   1966 C CB  . VAL A 1 442 ? 16.424  32.977  66.241  1.00 98.80  ? 423 VAL A CB  1 
ATOM   1967 C CG1 . VAL A 1 442 ? 16.360  32.659  64.768  1.00 106.49 ? 423 VAL A CG1 1 
ATOM   1968 C CG2 . VAL A 1 442 ? 15.021  32.855  66.762  1.00 99.48  ? 423 VAL A CG2 1 
ATOM   1969 N N   . LYS A 1 443 ? 19.495  32.539  66.057  1.00 106.29 ? 424 LYS A N   1 
ATOM   1970 C CA  . LYS A 1 443 ? 20.706  32.286  65.292  1.00 101.46 ? 424 LYS A CA  1 
ATOM   1971 C C   . LYS A 1 443 ? 21.508  31.138  65.896  1.00 101.49 ? 424 LYS A C   1 
ATOM   1972 O O   . LYS A 1 443 ? 21.895  30.214  65.179  1.00 108.91 ? 424 LYS A O   1 
ATOM   1973 C CB  . LYS A 1 443 ? 21.522  33.569  65.194  1.00 95.50  ? 424 LYS A CB  1 
ATOM   1974 C CG  . LYS A 1 443 ? 20.713  34.651  64.520  1.00 95.58  ? 424 LYS A CG  1 
ATOM   1975 C CD  . LYS A 1 443 ? 21.557  35.796  64.036  1.00 100.14 ? 424 LYS A CD  1 
ATOM   1976 C CE  . LYS A 1 443 ? 20.649  36.929  63.601  1.00 106.88 ? 424 LYS A CE  1 
ATOM   1977 N NZ  . LYS A 1 443 ? 19.669  36.463  62.587  1.00 103.22 ? 424 LYS A NZ  1 
ATOM   1978 N N   . ASP A 1 444 ? 21.731  31.154  67.213  1.00 97.31  ? 425 ASP A N   1 
ATOM   1979 C CA  . ASP A 1 444 ? 22.441  30.054  67.867  1.00 101.22 ? 425 ASP A CA  1 
ATOM   1980 C C   . ASP A 1 444 ? 21.909  28.694  67.420  1.00 108.94 ? 425 ASP A C   1 
ATOM   1981 O O   . ASP A 1 444 ? 22.686  27.792  67.081  1.00 106.18 ? 425 ASP A O   1 
ATOM   1982 C CB  . ASP A 1 444 ? 22.338  30.175  69.391  1.00 102.56 ? 425 ASP A CB  1 
ATOM   1983 C CG  . ASP A 1 444 ? 23.434  31.043  69.994  1.00 111.03 ? 425 ASP A CG  1 
ATOM   1984 O OD1 . ASP A 1 444 ? 24.081  31.783  69.229  1.00 113.86 ? 425 ASP A OD1 1 
ATOM   1985 O OD2 . ASP A 1 444 ? 23.639  30.995  71.238  1.00 116.29 ? 425 ASP A OD2 1 
ATOM   1986 N N   . GLU A 1 445 ? 20.582  28.524  67.404  1.00 110.19 ? 426 GLU A N   1 
ATOM   1987 C CA  . GLU A 1 445 ? 20.053  27.196  67.109  1.00 110.03 ? 426 GLU A CA  1 
ATOM   1988 C C   . GLU A 1 445 ? 20.148  26.854  65.635  1.00 108.97 ? 426 GLU A C   1 
ATOM   1989 O O   . GLU A 1 445 ? 20.204  25.670  65.288  1.00 115.82 ? 426 GLU A O   1 
ATOM   1990 C CB  . GLU A 1 445 ? 18.610  27.029  67.591  1.00 110.52 ? 426 GLU A CB  1 
ATOM   1991 C CG  . GLU A 1 445 ? 18.528  26.412  68.992  1.00 114.49 ? 426 GLU A CG  1 
ATOM   1992 C CD  . GLU A 1 445 ? 17.220  25.665  69.222  1.00 124.74 ? 426 GLU A CD  1 
ATOM   1993 O OE1 . GLU A 1 445 ? 16.300  25.805  68.377  1.00 123.44 ? 426 GLU A OE1 1 
ATOM   1994 O OE2 . GLU A 1 445 ? 17.134  24.910  70.226  1.00 122.34 ? 426 GLU A OE2 1 
ATOM   1995 N N   . GLN A 1 446 ? 20.164  27.847  64.752  1.00 108.35 ? 427 GLN A N   1 
ATOM   1996 C CA  . GLN A 1 446 ? 20.476  27.539  63.361  1.00 106.92 ? 427 GLN A CA  1 
ATOM   1997 C C   . GLN A 1 446 ? 21.922  27.076  63.226  1.00 105.32 ? 427 GLN A C   1 
ATOM   1998 O O   . GLN A 1 446 ? 22.194  26.050  62.599  1.00 102.56 ? 427 GLN A O   1 
ATOM   1999 C CB  . GLN A 1 446 ? 20.182  28.743  62.474  1.00 103.32 ? 427 GLN A CB  1 
ATOM   2000 C CG  . GLN A 1 446 ? 18.701  29.002  62.335  1.00 109.23 ? 427 GLN A CG  1 
ATOM   2001 C CD  . GLN A 1 446 ? 18.400  30.231  61.505  1.00 116.39 ? 427 GLN A CD  1 
ATOM   2002 O OE1 . GLN A 1 446 ? 19.313  30.918  61.039  1.00 114.09 ? 427 GLN A OE1 1 
ATOM   2003 N NE2 . GLN A 1 446 ? 17.113  30.528  61.330  1.00 119.73 ? 427 GLN A NE2 1 
ATOM   2004 N N   . ILE A 1 447 ? 22.854  27.788  63.861  1.00 103.65 ? 428 ILE A N   1 
ATOM   2005 C CA  . ILE A 1 447 ? 24.256  27.374  63.865  1.00 98.79  ? 428 ILE A CA  1 
ATOM   2006 C C   . ILE A 1 447 ? 24.379  25.923  64.330  1.00 107.50 ? 428 ILE A C   1 
ATOM   2007 O O   . ILE A 1 447 ? 24.868  25.056  63.598  1.00 111.49 ? 428 ILE A O   1 
ATOM   2008 C CB  . ILE A 1 447 ? 25.096  28.308  64.753  1.00 99.23  ? 428 ILE A CB  1 
ATOM   2009 C CG1 . ILE A 1 447 ? 24.990  29.772  64.323  1.00 102.01 ? 428 ILE A CG1 1 
ATOM   2010 C CG2 . ILE A 1 447 ? 26.534  27.888  64.710  1.00 103.06 ? 428 ILE A CG2 1 
ATOM   2011 C CD1 . ILE A 1 447 ? 25.466  30.086  62.953  1.00 100.82 ? 428 ILE A CD1 1 
ATOM   2012 N N   . GLU A 1 448 ? 23.927  25.632  65.563  1.00 108.79 ? 429 GLU A N   1 
ATOM   2013 C CA  . GLU A 1 448 ? 24.079  24.288  66.130  1.00 109.50 ? 429 GLU A CA  1 
ATOM   2014 C C   . GLU A 1 448 ? 23.482  23.212  65.225  1.00 110.41 ? 429 GLU A C   1 
ATOM   2015 O O   . GLU A 1 448 ? 23.972  22.076  65.198  1.00 111.13 ? 429 GLU A O   1 
ATOM   2016 C CB  . GLU A 1 448 ? 23.440  24.224  67.522  1.00 110.10 ? 429 GLU A CB  1 
ATOM   2017 C CG  . GLU A 1 448 ? 23.573  22.866  68.215  1.00 115.62 ? 429 GLU A CG  1 
ATOM   2018 C CD  . GLU A 1 448 ? 22.690  22.724  69.449  1.00 129.29 ? 429 GLU A CD  1 
ATOM   2019 O OE1 . GLU A 1 448 ? 23.231  22.711  70.584  1.00 130.25 ? 429 GLU A OE1 1 
ATOM   2020 O OE2 . GLU A 1 448 ? 21.451  22.613  69.278  1.00 129.63 ? 429 GLU A OE2 1 
ATOM   2021 N N   . HIS A 1 449 ? 22.442  23.553  64.463  1.00 105.06 ? 430 HIS A N   1 
ATOM   2022 C CA  . HIS A 1 449 ? 21.758  22.558  63.650  1.00 102.46 ? 430 HIS A CA  1 
ATOM   2023 C C   . HIS A 1 449 ? 22.526  22.262  62.373  1.00 110.41 ? 430 HIS A C   1 
ATOM   2024 O O   . HIS A 1 449 ? 22.733  21.093  62.039  1.00 117.31 ? 430 HIS A O   1 
ATOM   2025 C CB  . HIS A 1 449 ? 20.343  23.032  63.356  1.00 105.35 ? 430 HIS A CB  1 
ATOM   2026 C CG  . HIS A 1 449 ? 19.714  22.429  62.140  1.00 105.17 ? 430 HIS A CG  1 
ATOM   2027 N ND1 . HIS A 1 449 ? 19.919  22.928  60.870  1.00 107.99 ? 430 HIS A ND1 1 
ATOM   2028 C CD2 . HIS A 1 449 ? 18.817  21.427  62.008  1.00 104.93 ? 430 HIS A CD2 1 
ATOM   2029 C CE1 . HIS A 1 449 ? 19.194  22.244  60.006  1.00 106.19 ? 430 HIS A CE1 1 
ATOM   2030 N NE2 . HIS A 1 449 ? 18.514  21.329  60.672  1.00 108.49 ? 430 HIS A NE2 1 
ATOM   2031 N N   . TRP A 1 450 ? 22.980  23.297  61.650  1.00 110.42 ? 431 TRP A N   1 
ATOM   2032 C CA  . TRP A 1 450 ? 23.830  23.039  60.486  1.00 105.79 ? 431 TRP A CA  1 
ATOM   2033 C C   . TRP A 1 450 ? 25.188  22.479  60.898  1.00 107.16 ? 431 TRP A C   1 
ATOM   2034 O O   . TRP A 1 450 ? 25.724  21.598  60.219  1.00 113.20 ? 431 TRP A O   1 
ATOM   2035 C CB  . TRP A 1 450 ? 24.030  24.289  59.646  1.00 98.99  ? 431 TRP A CB  1 
ATOM   2036 C CG  . TRP A 1 450 ? 22.793  24.968  59.193  1.00 107.29 ? 431 TRP A CG  1 
ATOM   2037 C CD1 . TRP A 1 450 ? 22.151  25.976  59.831  1.00 113.17 ? 431 TRP A CD1 1 
ATOM   2038 C CD2 . TRP A 1 450 ? 22.067  24.738  57.978  1.00 111.34 ? 431 TRP A CD2 1 
ATOM   2039 N NE1 . TRP A 1 450 ? 21.057  26.384  59.109  1.00 112.99 ? 431 TRP A NE1 1 
ATOM   2040 C CE2 . TRP A 1 450 ? 20.984  25.642  57.964  1.00 109.49 ? 431 TRP A CE2 1 
ATOM   2041 C CE3 . TRP A 1 450 ? 22.224  23.861  56.904  1.00 113.55 ? 431 TRP A CE3 1 
ATOM   2042 C CZ2 . TRP A 1 450 ? 20.062  25.692  56.926  1.00 110.95 ? 431 TRP A CZ2 1 
ATOM   2043 C CZ3 . TRP A 1 450 ? 21.303  23.915  55.868  1.00 116.28 ? 431 TRP A CZ3 1 
ATOM   2044 C CH2 . TRP A 1 450 ? 20.236  24.823  55.890  1.00 115.06 ? 431 TRP A CH2 1 
ATOM   2045 N N   . LYS A 1 451 ? 25.767  22.961  62.000  1.00 105.36 ? 432 LYS A N   1 
ATOM   2046 C CA  . LYS A 1 451 ? 26.974  22.312  62.504  1.00 107.08 ? 432 LYS A CA  1 
ATOM   2047 C C   . LYS A 1 451 ? 26.763  20.836  62.775  1.00 110.47 ? 432 LYS A C   1 
ATOM   2048 O O   . LYS A 1 451 ? 27.743  20.107  62.956  1.00 113.71 ? 432 LYS A O   1 
ATOM   2049 C CB  . LYS A 1 451 ? 27.484  22.986  63.784  1.00 106.50 ? 432 LYS A CB  1 
ATOM   2050 C CG  . LYS A 1 451 ? 28.292  24.250  63.514  1.00 113.11 ? 432 LYS A CG  1 
ATOM   2051 C CD  . LYS A 1 451 ? 29.542  24.372  64.390  1.00 117.92 ? 432 LYS A CD  1 
ATOM   2052 C CE  . LYS A 1 451 ? 30.061  25.823  64.395  1.00 120.46 ? 432 LYS A CE  1 
ATOM   2053 N NZ  . LYS A 1 451 ? 31.324  26.029  65.180  1.00 123.00 ? 432 LYS A NZ  1 
ATOM   2054 N N   . LYS A 1 452 ? 25.519  20.379  62.821  1.00 110.75 ? 433 LYS A N   1 
ATOM   2055 C CA  . LYS A 1 452 ? 25.252  18.962  62.986  1.00 111.83 ? 433 LYS A CA  1 
ATOM   2056 C C   . LYS A 1 452 ? 25.008  18.295  61.638  1.00 110.30 ? 433 LYS A C   1 
ATOM   2057 O O   . LYS A 1 452 ? 25.030  17.067  61.548  1.00 117.10 ? 433 LYS A O   1 
ATOM   2058 C CB  . LYS A 1 452 ? 24.046  18.779  63.934  1.00 116.03 ? 433 LYS A CB  1 
ATOM   2059 C CG  . LYS A 1 452 ? 23.806  17.376  64.500  1.00 117.62 ? 433 LYS A CG  1 
ATOM   2060 C CD  . LYS A 1 452 ? 22.425  17.332  65.186  1.00 125.58 ? 433 LYS A CD  1 
ATOM   2061 C CE  . LYS A 1 452 ? 22.278  18.066  66.540  1.00 127.47 ? 433 LYS A CE  1 
ATOM   2062 N NZ  . LYS A 1 452 ? 20.863  17.804  66.992  1.00 127.69 ? 433 LYS A NZ  1 
ATOM   2063 N N   . ILE A 1 453 ? 24.799  19.080  60.586  1.00 105.18 ? 434 ILE A N   1 
ATOM   2064 C CA  . ILE A 1 453 ? 24.899  18.532  59.240  1.00 106.25 ? 434 ILE A CA  1 
ATOM   2065 C C   . ILE A 1 453 ? 26.360  18.384  58.815  1.00 109.40 ? 434 ILE A C   1 
ATOM   2066 O O   . ILE A 1 453 ? 26.777  17.296  58.404  1.00 114.54 ? 434 ILE A O   1 
ATOM   2067 C CB  . ILE A 1 453 ? 24.098  19.370  58.232  1.00 104.20 ? 434 ILE A CB  1 
ATOM   2068 C CG1 . ILE A 1 453 ? 22.601  19.272  58.509  1.00 103.64 ? 434 ILE A CG1 1 
ATOM   2069 C CG2 . ILE A 1 453 ? 24.401  18.928  56.815  1.00 106.52 ? 434 ILE A CG2 1 
ATOM   2070 C CD1 . ILE A 1 453 ? 21.783  20.246  57.665  1.00 110.34 ? 434 ILE A CD1 1 
ATOM   2071 N N   . VAL A 1 454 ? 27.170  19.449  58.899  1.00 106.19 ? 435 VAL A N   1 
ATOM   2072 C CA  . VAL A 1 454 ? 28.587  19.281  58.568  1.00 103.66 ? 435 VAL A CA  1 
ATOM   2073 C C   . VAL A 1 454 ? 29.183  18.118  59.359  1.00 110.85 ? 435 VAL A C   1 
ATOM   2074 O O   . VAL A 1 454 ? 29.955  17.324  58.816  1.00 118.93 ? 435 VAL A O   1 
ATOM   2075 C CB  . VAL A 1 454 ? 29.410  20.572  58.784  1.00 99.89  ? 435 VAL A CB  1 
ATOM   2076 C CG1 . VAL A 1 454 ? 28.937  21.710  57.917  1.00 100.14 ? 435 VAL A CG1 1 
ATOM   2077 C CG2 . VAL A 1 454 ? 29.473  20.969  60.253  1.00 109.82 ? 435 VAL A CG2 1 
ATOM   2078 N N   . LYS A 1 455 ? 28.823  17.974  60.639  1.00 108.06 ? 436 LYS A N   1 
ATOM   2079 C CA  . LYS A 1 455 ? 29.401  16.877  61.408  1.00 112.87 ? 436 LYS A CA  1 
ATOM   2080 C C   . LYS A 1 455 ? 29.016  15.525  60.828  1.00 118.31 ? 436 LYS A C   1 
ATOM   2081 O O   . LYS A 1 455 ? 29.732  14.541  61.046  1.00 122.56 ? 436 LYS A O   1 
ATOM   2082 C CB  . LYS A 1 455 ? 28.989  16.948  62.883  1.00 116.04 ? 436 LYS A CB  1 
ATOM   2083 C CG  . LYS A 1 455 ? 29.913  16.176  63.848  1.00 115.57 ? 436 LYS A CG  1 
ATOM   2084 C CD  . LYS A 1 455 ? 31.079  17.047  64.349  1.00 122.62 ? 436 LYS A CD  1 
ATOM   2085 C CE  . LYS A 1 455 ? 31.755  16.468  65.605  1.00 118.25 ? 436 LYS A CE  1 
ATOM   2086 N NZ  . LYS A 1 455 ? 33.097  17.084  65.867  1.00 114.31 ? 436 LYS A NZ  1 
ATOM   2087 N N   . THR A 1 456 ? 27.918  15.458  60.077  1.00 115.65 ? 437 THR A N   1 
ATOM   2088 C CA  . THR A 1 456 ? 27.503  14.209  59.457  1.00 115.91 ? 437 THR A CA  1 
ATOM   2089 C C   . THR A 1 456 ? 27.908  14.118  57.989  1.00 114.15 ? 437 THR A C   1 
ATOM   2090 O O   . THR A 1 456 ? 28.431  13.083  57.578  1.00 120.98 ? 437 THR A O   1 
ATOM   2091 C CB  . THR A 1 456 ? 25.989  14.001  59.638  1.00 116.35 ? 437 THR A CB  1 
ATOM   2092 O OG1 . THR A 1 456 ? 25.727  13.676  61.016  1.00 119.32 ? 437 THR A OG1 1 
ATOM   2093 C CG2 . THR A 1 456 ? 25.490  12.858  58.790  1.00 116.39 ? 437 THR A CG2 1 
ATOM   2094 N N   . GLN A 1 457 ? 27.752  15.182  57.192  1.00 111.72 ? 438 GLN A N   1 
ATOM   2095 C CA  . GLN A 1 457 ? 28.314  15.163  55.839  1.00 105.87 ? 438 GLN A CA  1 
ATOM   2096 C C   . GLN A 1 457 ? 29.788  14.789  55.839  1.00 107.55 ? 438 GLN A C   1 
ATOM   2097 O O   . GLN A 1 457 ? 30.254  14.130  54.909  1.00 114.15 ? 438 GLN A O   1 
ATOM   2098 C CB  . GLN A 1 457 ? 28.162  16.516  55.146  1.00 102.18 ? 438 GLN A CB  1 
ATOM   2099 C CG  . GLN A 1 457 ? 26.750  16.936  54.852  1.00 104.55 ? 438 GLN A CG  1 
ATOM   2100 C CD  . GLN A 1 457 ? 26.277  16.513  53.485  1.00 104.99 ? 438 GLN A CD  1 
ATOM   2101 O OE1 . GLN A 1 457 ? 25.993  15.346  53.273  1.00 108.57 ? 438 GLN A OE1 1 
ATOM   2102 N NE2 . GLN A 1 457 ? 26.170  17.464  52.551  1.00 103.48 ? 438 GLN A NE2 1 
ATOM   2103 N N   . GLU A 1 458 ? 30.540  15.192  56.863  1.00 110.35 ? 439 GLU A N   1 
ATOM   2104 C CA  . GLU A 1 458 ? 31.960  14.859  56.926  1.00 112.18 ? 439 GLU A CA  1 
ATOM   2105 C C   . GLU A 1 458 ? 32.206  13.435  57.399  1.00 112.23 ? 439 GLU A C   1 
ATOM   2106 O O   . GLU A 1 458 ? 33.237  12.846  57.054  1.00 113.07 ? 439 GLU A O   1 
ATOM   2107 C CB  . GLU A 1 458 ? 32.692  15.834  57.843  1.00 119.98 ? 439 GLU A CB  1 
ATOM   2108 C CG  . GLU A 1 458 ? 33.135  17.089  57.134  1.00 121.53 ? 439 GLU A CG  1 
ATOM   2109 C CD  . GLU A 1 458 ? 34.183  17.891  57.901  1.00 136.75 ? 439 GLU A CD  1 
ATOM   2110 O OE1 . GLU A 1 458 ? 35.029  17.275  58.592  1.00 144.00 ? 439 GLU A OE1 1 
ATOM   2111 O OE2 . GLU A 1 458 ? 34.167  19.139  57.802  1.00 135.81 ? 439 GLU A OE2 1 
ATOM   2112 N N   . GLU A 1 459 ? 31.307  12.883  58.214  1.00 112.54 ? 440 GLU A N   1 
ATOM   2113 C CA  . GLU A 1 459 ? 31.356  11.455  58.508  1.00 114.82 ? 440 GLU A CA  1 
ATOM   2114 C C   . GLU A 1 459 ? 31.028  10.640  57.260  1.00 114.18 ? 440 GLU A C   1 
ATOM   2115 O O   . GLU A 1 459 ? 31.571  9.547   57.063  1.00 112.99 ? 440 GLU A O   1 
ATOM   2116 C CB  . GLU A 1 459 ? 30.386  11.139  59.646  1.00 116.64 ? 440 GLU A CB  1 
ATOM   2117 C CG  . GLU A 1 459 ? 30.736  9.934   60.505  1.00 127.02 ? 440 GLU A CG  1 
ATOM   2118 C CD  . GLU A 1 459 ? 29.766  9.756   61.681  1.00 138.45 ? 440 GLU A CD  1 
ATOM   2119 O OE1 . GLU A 1 459 ? 28.658  10.350  61.638  1.00 135.36 ? 440 GLU A OE1 1 
ATOM   2120 O OE2 . GLU A 1 459 ? 30.115  9.035   62.652  1.00 145.04 ? 440 GLU A OE2 1 
ATOM   2121 N N   . LEU A 1 460 ? 30.150  11.172  56.408  1.00 108.79 ? 441 LEU A N   1 
ATOM   2122 C CA  . LEU A 1 460 ? 29.868  10.555  55.121  1.00 104.34 ? 441 LEU A CA  1 
ATOM   2123 C C   . LEU A 1 460 ? 31.043  10.712  54.168  1.00 109.64 ? 441 LEU A C   1 
ATOM   2124 O O   . LEU A 1 460 ? 31.340  9.802   53.388  1.00 112.70 ? 441 LEU A O   1 
ATOM   2125 C CB  . LEU A 1 460 ? 28.612  11.178  54.516  1.00 104.93 ? 441 LEU A CB  1 
ATOM   2126 C CG  . LEU A 1 460 ? 28.066  10.573  53.229  1.00 102.76 ? 441 LEU A CG  1 
ATOM   2127 C CD1 . LEU A 1 460 ? 27.578  9.185   53.535  1.00 111.15 ? 441 LEU A CD1 1 
ATOM   2128 C CD2 . LEU A 1 460 ? 26.951  11.419  52.627  1.00 98.13  ? 441 LEU A CD2 1 
ATOM   2129 N N   . LYS A 1 461 ? 31.569  11.922  54.070  1.00 109.93 ? 442 LYS A N   1 
ATOM   2130 C CA  . LYS A 1 461 ? 32.656  12.097  53.087  1.00 104.00 ? 442 LYS A CA  1 
ATOM   2131 C C   . LYS A 1 461 ? 33.797  11.182  53.494  1.00 108.25 ? 442 LYS A C   1 
ATOM   2132 O O   . LYS A 1 461 ? 34.268  10.455  52.662  1.00 113.02 ? 442 LYS A O   1 
ATOM   2133 C CB  . LYS A 1 461 ? 33.138  13.538  53.007  1.00 99.13  ? 442 LYS A CB  1 
ATOM   2134 C CG  . LYS A 1 461 ? 34.636  13.653  52.838  1.00 96.06  ? 442 LYS A CG  1 
ATOM   2135 C CD  . LYS A 1 461 ? 35.086  15.029  52.489  1.00 100.69 ? 442 LYS A CD  1 
ATOM   2136 C CE  . LYS A 1 461 ? 36.255  15.460  53.340  1.00 105.40 ? 442 LYS A CE  1 
ATOM   2137 N NZ  . LYS A 1 461 ? 36.567  16.892  53.152  1.00 110.93 ? 442 LYS A NZ  1 
ATOM   2138 N N   . GLU A 1 462 ? 34.105  11.104  54.776  1.00 108.46 ? 443 GLU A N   1 
ATOM   2139 C CA  . GLU A 1 462 ? 35.219  10.215  55.167  1.00 111.38 ? 443 GLU A CA  1 
ATOM   2140 C C   . GLU A 1 462 ? 34.848  8.772   54.862  1.00 111.36 ? 443 GLU A C   1 
ATOM   2141 O O   . GLU A 1 462 ? 35.707  8.038   54.415  1.00 114.74 ? 443 GLU A O   1 
ATOM   2142 C CB  . GLU A 1 462 ? 35.574  10.388  56.638  1.00 111.97 ? 443 GLU A CB  1 
ATOM   2143 C CG  . GLU A 1 462 ? 36.671  11.408  56.844  1.00 123.82 ? 443 GLU A CG  1 
ATOM   2144 C CD  . GLU A 1 462 ? 37.754  10.985  57.814  1.00 133.07 ? 443 GLU A CD  1 
ATOM   2145 O OE1 . GLU A 1 462 ? 37.514  10.041  58.577  1.00 136.40 ? 443 GLU A OE1 1 
ATOM   2146 O OE2 . GLU A 1 462 ? 38.828  11.603  57.800  1.00 134.20 ? 443 GLU A OE2 1 
ATOM   2147 N N   . LEU A 1 463 ? 33.602  8.381   55.074  1.00 106.44 ? 444 LEU A N   1 
ATOM   2148 C CA  . LEU A 1 463 ? 33.274  6.977   54.773  1.00 102.76 ? 444 LEU A CA  1 
ATOM   2149 C C   . LEU A 1 463 ? 33.203  6.792   53.266  1.00 107.85 ? 444 LEU A C   1 
ATOM   2150 O O   . LEU A 1 463 ? 33.495  5.709   52.830  1.00 112.19 ? 444 LEU A O   1 
ATOM   2151 C CB  . LEU A 1 463 ? 31.960  6.598   55.441  1.00 102.67 ? 444 LEU A CB  1 
ATOM   2152 C CG  . LEU A 1 463 ? 31.211  5.467   54.761  1.00 100.30 ? 444 LEU A CG  1 
ATOM   2153 C CD1 . LEU A 1 463 ? 30.298  4.773   55.743  1.00 99.08  ? 444 LEU A CD1 1 
ATOM   2154 C CD2 . LEU A 1 463 ? 30.404  6.004   53.611  1.00 105.35 ? 444 LEU A CD2 1 
ATOM   2155 N N   . LEU A 1 464 ? 32.852  7.815   52.499  1.00 108.88 ? 445 LEU A N   1 
ATOM   2156 C CA  . LEU A 1 464 ? 32.818  7.602   51.032  1.00 107.25 ? 445 LEU A CA  1 
ATOM   2157 C C   . LEU A 1 464 ? 34.226  7.251   50.578  1.00 108.70 ? 445 LEU A C   1 
ATOM   2158 O O   . LEU A 1 464 ? 34.369  6.273   49.861  1.00 111.68 ? 445 LEU A O   1 
ATOM   2159 C CB  . LEU A 1 464 ? 32.331  8.867   50.337  1.00 103.28 ? 445 LEU A CB  1 
ATOM   2160 C CG  . LEU A 1 464 ? 30.820  8.995   50.319  1.00 103.11 ? 445 LEU A CG  1 
ATOM   2161 C CD1 . LEU A 1 464 ? 30.339  9.605   49.028  1.00 104.61 ? 445 LEU A CD1 1 
ATOM   2162 C CD2 . LEU A 1 464 ? 30.209  7.634   50.506  1.00 105.88 ? 445 LEU A CD2 1 
ATOM   2163 N N   . ASN A 1 465 ? 35.203  8.024   51.037  1.00 109.98 ? 446 ASN A N   1 
ATOM   2164 C CA  . ASN A 1 465 ? 36.629  7.806   50.715  1.00 109.48 ? 446 ASN A CA  1 
ATOM   2165 C C   . ASN A 1 465 ? 36.971  6.338   50.907  1.00 108.32 ? 446 ASN A C   1 
ATOM   2166 O O   . ASN A 1 465 ? 37.356  5.721   49.937  1.00 110.67 ? 446 ASN A O   1 
ATOM   2167 C CB  . ASN A 1 465 ? 37.532  8.670   51.577  1.00 107.86 ? 446 ASN A CB  1 
ATOM   2168 C CG  . ASN A 1 465 ? 38.160  9.759   50.749  1.00 110.20 ? 446 ASN A CG  1 
ATOM   2169 O OD1 . ASN A 1 465 ? 37.555  10.237  49.804  1.00 105.58 ? 446 ASN A OD1 1 
ATOM   2170 N ND2 . ASN A 1 465 ? 39.376  10.136  51.080  1.00 117.02 ? 446 ASN A ND2 1 
ATOM   2171 N N   . LYS A 1 466 ? 36.694  5.782   52.078  1.00 108.56 ? 447 LYS A N   1 
ATOM   2172 C CA  . LYS A 1 466 ? 36.992  4.352   52.331  1.00 113.65 ? 447 LYS A CA  1 
ATOM   2173 C C   . LYS A 1 466 ? 36.291  3.493   51.288  1.00 108.95 ? 447 LYS A C   1 
ATOM   2174 O O   . LYS A 1 466 ? 36.928  2.629   50.727  1.00 111.09 ? 447 LYS A O   1 
ATOM   2175 C CB  . LYS A 1 466 ? 36.517  3.942   53.723  1.00 113.80 ? 447 LYS A CB  1 
ATOM   2176 C CG  . LYS A 1 466 ? 37.609  3.890   54.778  1.00 118.01 ? 447 LYS A CG  1 
ATOM   2177 C CD  . LYS A 1 466 ? 37.330  2.912   55.890  1.00 126.76 ? 447 LYS A CD  1 
ATOM   2178 C CE  . LYS A 1 466 ? 38.540  2.078   56.250  1.00 130.88 ? 447 LYS A CE  1 
ATOM   2179 N NZ  . LYS A 1 466 ? 38.565  1.703   57.685  1.00 131.49 ? 447 LYS A NZ  1 
ATOM   2180 N N   . MET A 1 467 ? 35.031  3.766   51.006  1.00 102.26 ? 448 MET A N   1 
ATOM   2181 C CA  . MET A 1 467 ? 34.334  2.954   49.995  1.00 104.66 ? 448 MET A CA  1 
ATOM   2182 C C   . MET A 1 467 ? 35.006  3.131   48.644  1.00 104.94 ? 448 MET A C   1 
ATOM   2183 O O   . MET A 1 467 ? 35.188  2.158   47.956  1.00 106.17 ? 448 MET A O   1 
ATOM   2184 C CB  . MET A 1 467 ? 32.880  3.392   49.897  1.00 110.64 ? 448 MET A CB  1 
ATOM   2185 C CG  . MET A 1 467 ? 32.178  3.263   51.208  1.00 113.65 ? 448 MET A CG  1 
ATOM   2186 S SD  . MET A 1 467 ? 30.474  2.873   50.938  1.00 128.91 ? 448 MET A SD  1 
ATOM   2187 C CE  . MET A 1 467 ? 30.285  3.445   49.256  1.00 113.54 ? 448 MET A CE  1 
ATOM   2188 N N   . VAL A 1 468 ? 35.408  4.332   48.281  1.00 108.42 ? 449 VAL A N   1 
ATOM   2189 C CA  . VAL A 1 468 ? 36.016  4.441   46.928  1.00 103.11 ? 449 VAL A CA  1 
ATOM   2190 C C   . VAL A 1 468 ? 37.375  3.754   46.923  1.00 101.22 ? 449 VAL A C   1 
ATOM   2191 O O   . VAL A 1 468 ? 37.706  3.156   45.930  1.00 110.35 ? 449 VAL A O   1 
ATOM   2192 C CB  . VAL A 1 468 ? 36.089  5.892   46.440  1.00 100.26 ? 449 VAL A CB  1 
ATOM   2193 C CG1 . VAL A 1 468 ? 37.494  6.291   46.055  1.00 97.43  ? 449 VAL A CG1 1 
ATOM   2194 C CG2 . VAL A 1 468 ? 35.153  6.105   45.272  1.00 109.23 ? 449 VAL A CG2 1 
ATOM   2195 N N   . ASN A 1 469 ? 38.113  3.799   48.020  1.00 99.76  ? 450 ASN A N   1 
ATOM   2196 C CA  . ASN A 1 469 ? 39.441  3.152   48.022  1.00 102.58 ? 450 ASN A CA  1 
ATOM   2197 C C   . ASN A 1 469 ? 39.253  1.644   48.038  1.00 105.94 ? 450 ASN A C   1 
ATOM   2198 O O   . ASN A 1 469 ? 40.062  0.954   47.463  1.00 109.11 ? 450 ASN A O   1 
ATOM   2199 C CB  . ASN A 1 469 ? 40.290  3.643   49.184  1.00 100.25 ? 450 ASN A CB  1 
ATOM   2200 C CG  . ASN A 1 469 ? 41.036  4.902   48.823  1.00 104.63 ? 450 ASN A CG  1 
ATOM   2201 O OD1 . ASN A 1 469 ? 40.542  5.715   48.062  1.00 106.26 ? 450 ASN A OD1 1 
ATOM   2202 N ND2 . ASN A 1 469 ? 42.233  5.061   49.348  1.00 107.38 ? 450 ASN A ND2 1 
ATOM   2203 N N   . LEU A 1 470 ? 38.203  1.158   48.674  1.00 105.50 ? 451 LEU A N   1 
ATOM   2204 C CA  . LEU A 1 470 ? 37.999  -0.302  48.724  1.00 100.77 ? 451 LEU A CA  1 
ATOM   2205 C C   . LEU A 1 470 ? 37.556  -0.796  47.356  1.00 98.31  ? 451 LEU A C   1 
ATOM   2206 O O   . LEU A 1 470 ? 38.006  -1.845  46.955  1.00 100.33 ? 451 LEU A O   1 
ATOM   2207 C CB  . LEU A 1 470 ? 36.923  -0.597  49.759  1.00 95.81  ? 451 LEU A CB  1 
ATOM   2208 C CG  . LEU A 1 470 ? 37.016  -1.972  50.390  1.00 95.98  ? 451 LEU A CG  1 
ATOM   2209 C CD1 . LEU A 1 470 ? 38.047  -1.974  51.490  1.00 100.26 ? 451 LEU A CD1 1 
ATOM   2210 C CD2 . LEU A 1 470 ? 35.671  -2.384  50.934  1.00 103.63 ? 451 LEU A CD2 1 
ATOM   2211 N N   . LYS A 1 471 ? 36.715  -0.047  46.660  1.00 100.04 ? 452 LYS A N   1 
ATOM   2212 C CA  . LYS A 1 471 ? 36.248  -0.530  45.342  1.00 101.16 ? 452 LYS A CA  1 
ATOM   2213 C C   . LYS A 1 471 ? 37.447  -0.719  44.428  1.00 104.97 ? 452 LYS A C   1 
ATOM   2214 O O   . LYS A 1 471 ? 37.526  -1.752  43.796  1.00 110.26 ? 452 LYS A O   1 
ATOM   2215 C CB  . LYS A 1 471 ? 35.295  0.465   44.693  1.00 97.97  ? 452 LYS A CB  1 
ATOM   2216 C CG  . LYS A 1 471 ? 34.723  0.012   43.365  1.00 101.95 ? 452 LYS A CG  1 
ATOM   2217 C CD  . LYS A 1 471 ? 33.824  1.047   42.752  1.00 110.19 ? 452 LYS A CD  1 
ATOM   2218 C CE  . LYS A 1 471 ? 32.794  0.487   41.803  1.00 115.69 ? 452 LYS A CE  1 
ATOM   2219 N NZ  . LYS A 1 471 ? 32.883  1.129   40.473  1.00 114.38 ? 452 LYS A NZ  1 
ATOM   2220 N N   . GLU A 1 472 ? 38.360  0.240   44.396  1.00 103.60 ? 453 GLU A N   1 
ATOM   2221 C CA  . GLU A 1 472 ? 39.559  0.085   43.552  1.00 104.55 ? 453 GLU A CA  1 
ATOM   2222 C C   . GLU A 1 472 ? 40.286  -1.175  43.994  1.00 104.13 ? 453 GLU A C   1 
ATOM   2223 O O   . GLU A 1 472 ? 40.606  -1.970  43.141  1.00 108.41 ? 453 GLU A O   1 
ATOM   2224 C CB  . GLU A 1 472 ? 40.454  1.306   43.683  1.00 106.04 ? 453 GLU A CB  1 
ATOM   2225 C CG  . GLU A 1 472 ? 39.791  2.571   43.188  1.00 120.30 ? 453 GLU A CG  1 
ATOM   2226 C CD  . GLU A 1 472 ? 38.938  2.389   41.948  1.00 136.77 ? 453 GLU A CD  1 
ATOM   2227 O OE1 . GLU A 1 472 ? 39.170  1.415   41.234  1.00 143.62 ? 453 GLU A OE1 1 
ATOM   2228 O OE2 . GLU A 1 472 ? 38.049  3.228   41.699  1.00 131.54 ? 453 GLU A OE2 1 
ATOM   2229 N N   . LYS A 1 473 ? 40.504  -1.348  45.290  1.00 104.82 ? 454 LYS A N   1 
ATOM   2230 C CA  . LYS A 1 473 ? 41.186  -2.566  45.776  1.00 104.83 ? 454 LYS A CA  1 
ATOM   2231 C C   . LYS A 1 473 ? 40.388  -3.776  45.309  1.00 102.53 ? 454 LYS A C   1 
ATOM   2232 O O   . LYS A 1 473 ? 40.971  -4.745  44.899  1.00 101.59 ? 454 LYS A O   1 
ATOM   2233 C CB  . LYS A 1 473 ? 41.189  -2.584  47.301  1.00 101.04 ? 454 LYS A CB  1 
ATOM   2234 C CG  . LYS A 1 473 ? 42.417  -1.992  47.964  1.00 104.64 ? 454 LYS A CG  1 
ATOM   2235 C CD  . LYS A 1 473 ? 42.457  -2.301  49.440  1.00 118.17 ? 454 LYS A CD  1 
ATOM   2236 C CE  . LYS A 1 473 ? 42.982  -1.167  50.294  1.00 115.86 ? 454 LYS A CE  1 
ATOM   2237 N NZ  . LYS A 1 473 ? 41.986  -0.085  50.458  1.00 104.44 ? 454 LYS A NZ  1 
ATOM   2238 N N   . ILE A 1 474 ? 39.078  -3.710  45.393  1.00 100.27 ? 455 ILE A N   1 
ATOM   2239 C CA  . ILE A 1 474 ? 38.310  -4.888  44.934  1.00 96.36  ? 455 ILE A CA  1 
ATOM   2240 C C   . ILE A 1 474 ? 38.552  -5.060  43.447  1.00 103.08 ? 455 ILE A C   1 
ATOM   2241 O O   . ILE A 1 474 ? 38.852  -6.162  43.042  1.00 102.30 ? 455 ILE A O   1 
ATOM   2242 C CB  . ILE A 1 474 ? 36.827  -4.661  45.202  1.00 98.55  ? 455 ILE A CB  1 
ATOM   2243 C CG1 . ILE A 1 474 ? 36.528  -4.779  46.691  1.00 101.99 ? 455 ILE A CG1 1 
ATOM   2244 C CG2 . ILE A 1 474 ? 36.011  -5.628  44.383  1.00 101.46 ? 455 ILE A CG2 1 
ATOM   2245 C CD1 . ILE A 1 474 ? 35.079  -4.951  46.992  1.00 104.34 ? 455 ILE A CD1 1 
ATOM   2246 N N   . LYS A 1 475 ? 38.439  -3.975  42.694  1.00 106.66 ? 456 LYS A N   1 
ATOM   2247 C CA  . LYS A 1 475 ? 38.610  -3.981  41.223  1.00 101.40 ? 456 LYS A CA  1 
ATOM   2248 C C   . LYS A 1 475 ? 39.877  -4.736  40.847  1.00 100.55 ? 456 LYS A C   1 
ATOM   2249 O O   . LYS A 1 475 ? 39.793  -5.671  40.093  1.00 95.04  ? 456 LYS A O   1 
ATOM   2250 C CB  . LYS A 1 475 ? 38.734  -2.541  40.734  1.00 101.31 ? 456 LYS A CB  1 
ATOM   2251 C CG  . LYS A 1 475 ? 38.391  -2.320  39.273  1.00 112.50 ? 456 LYS A CG  1 
ATOM   2252 C CD  . LYS A 1 475 ? 39.201  -1.208  38.630  1.00 124.10 ? 456 LYS A CD  1 
ATOM   2253 C CE  . LYS A 1 475 ? 40.617  -1.600  38.251  1.00 118.23 ? 456 LYS A CE  1 
ATOM   2254 N NZ  . LYS A 1 475 ? 41.223  -0.661  37.275  1.00 107.91 ? 456 LYS A NZ  1 
ATOM   2255 N N   . GLU A 1 476 ? 41.001  -4.385  41.441  1.00 102.76 ? 457 GLU A N   1 
ATOM   2256 C CA  . GLU A 1 476 ? 42.255  -5.069  41.078  1.00 100.38 ? 457 GLU A CA  1 
ATOM   2257 C C   . GLU A 1 476 ? 42.285  -6.482  41.652  1.00 100.30 ? 457 GLU A C   1 
ATOM   2258 O O   . GLU A 1 476 ? 42.983  -7.306  41.102  1.00 103.12 ? 457 GLU A O   1 
ATOM   2259 C CB  . GLU A 1 476 ? 43.432  -4.237  41.553  1.00 100.84 ? 457 GLU A CB  1 
ATOM   2260 C CG  . GLU A 1 476 ? 44.246  -4.924  42.611  1.00 111.52 ? 457 GLU A CG  1 
ATOM   2261 C CD  . GLU A 1 476 ? 45.489  -4.131  42.938  1.00 122.21 ? 457 GLU A CD  1 
ATOM   2262 O OE1 . GLU A 1 476 ? 45.642  -3.045  42.375  1.00 129.58 ? 457 GLU A OE1 1 
ATOM   2263 O OE2 . GLU A 1 476 ? 46.292  -4.601  43.746  1.00 126.42 ? 457 GLU A OE2 1 
ATOM   2264 N N   . LEU A 1 477 ? 41.570  -6.760  42.728  1.00 98.52  ? 458 LEU A N   1 
ATOM   2265 C CA  . LEU A 1 477 ? 41.639  -8.146  43.231  1.00 94.83  ? 458 LEU A CA  1 
ATOM   2266 C C   . LEU A 1 477 ? 41.007  -9.037  42.180  1.00 95.79  ? 458 LEU A C   1 
ATOM   2267 O O   . LEU A 1 477 ? 41.629  -10.012 41.815  1.00 101.68 ? 458 LEU A O   1 
ATOM   2268 C CB  . LEU A 1 477 ? 40.864  -8.245  44.536  1.00 99.21  ? 458 LEU A CB  1 
ATOM   2269 C CG  . LEU A 1 477 ? 41.680  -8.756  45.711  1.00 103.62 ? 458 LEU A CG  1 
ATOM   2270 C CD1 . LEU A 1 477 ? 40.783  -9.413  46.734  1.00 101.08 ? 458 LEU A CD1 1 
ATOM   2271 C CD2 . LEU A 1 477 ? 42.707  -9.740  45.215  1.00 101.39 ? 458 LEU A CD2 1 
ATOM   2272 N N   . HIS A 1 478 ? 39.803  -8.685  41.758  1.00 93.69  ? 459 HIS A N   1 
ATOM   2273 C CA  . HIS A 1 478 ? 39.063  -9.409  40.734  1.00 91.12  ? 459 HIS A CA  1 
ATOM   2274 C C   . HIS A 1 478 ? 39.970  -9.749  39.566  1.00 98.39  ? 459 HIS A C   1 
ATOM   2275 O O   . HIS A 1 478 ? 40.104  -10.916 39.184  1.00 99.36  ? 459 HIS A O   1 
ATOM   2276 C CB  . HIS A 1 478 ? 37.884  -8.570  40.269  1.00 95.74  ? 459 HIS A CB  1 
ATOM   2277 C CG  . HIS A 1 478 ? 36.923  -9.306  39.400  1.00 93.67  ? 459 HIS A CG  1 
ATOM   2278 N ND1 . HIS A 1 478 ? 36.093  -10.294 39.885  1.00 96.74  ? 459 HIS A ND1 1 
ATOM   2279 C CD2 . HIS A 1 478 ? 36.629  -9.176  38.084  1.00 94.96  ? 459 HIS A CD2 1 
ATOM   2280 C CE1 . HIS A 1 478 ? 35.334  -10.748 38.901  1.00 100.83 ? 459 HIS A CE1 1 
ATOM   2281 N NE2 . HIS A 1 478 ? 35.639  -10.086 37.799  1.00 99.79  ? 459 HIS A NE2 1 
ATOM   2282 N N   . GLN A 1 479 ? 40.631  -8.730  39.008  1.00 103.39 ? 460 GLN A N   1 
ATOM   2283 C CA  . GLN A 1 479 ? 41.623  -8.953  37.965  1.00 100.33 ? 460 GLN A CA  1 
ATOM   2284 C C   . GLN A 1 479 ? 42.588  -10.063 38.357  1.00 97.11  ? 460 GLN A C   1 
ATOM   2285 O O   . GLN A 1 479 ? 42.781  -11.017 37.604  1.00 105.98 ? 460 GLN A O   1 
ATOM   2286 C CB  . GLN A 1 479 ? 42.379  -7.657  37.663  1.00 98.45  ? 460 GLN A CB  1 
ATOM   2287 C CG  . GLN A 1 479 ? 43.233  -7.723  36.398  1.00 112.56 ? 460 GLN A CG  1 
ATOM   2288 C CD  . GLN A 1 479 ? 42.533  -8.412  35.209  1.00 117.50 ? 460 GLN A CD  1 
ATOM   2289 O OE1 . GLN A 1 479 ? 41.339  -8.201  34.953  1.00 119.87 ? 460 GLN A OE1 1 
ATOM   2290 N NE2 . GLN A 1 479 ? 43.289  -9.236  34.477  1.00 106.31 ? 460 GLN A NE2 1 
ATOM   2291 N N   . GLN A 1 480 ? 43.171  -9.977  39.549  1.00 94.77  ? 461 GLN A N   1 
ATOM   2292 C CA  . GLN A 1 480 ? 44.105  -11.013 39.982  1.00 95.12  ? 461 GLN A CA  1 
ATOM   2293 C C   . GLN A 1 480 ? 43.433  -12.377 40.050  1.00 98.86  ? 461 GLN A C   1 
ATOM   2294 O O   . GLN A 1 480 ? 44.041  -13.391 39.694  1.00 102.61 ? 461 GLN A O   1 
ATOM   2295 C CB  . GLN A 1 480 ? 44.716  -10.649 41.333  1.00 94.52  ? 461 GLN A CB  1 
ATOM   2296 C CG  . GLN A 1 480 ? 45.241  -9.227  41.401  1.00 95.56  ? 461 GLN A CG  1 
ATOM   2297 C CD  . GLN A 1 480 ? 46.197  -9.011  42.542  1.00 99.39  ? 461 GLN A CD  1 
ATOM   2298 O OE1 . GLN A 1 480 ? 46.270  -9.818  43.475  1.00 102.08 ? 461 GLN A OE1 1 
ATOM   2299 N NE2 . GLN A 1 480 ? 46.947  -7.921  42.475  1.00 96.23  ? 461 GLN A NE2 1 
ATOM   2300 N N   . TYR A 1 481 ? 42.192  -12.401 40.500  1.00 98.25  ? 462 TYR A N   1 
ATOM   2301 C CA  . TYR A 1 481 ? 41.520  -13.708 40.636  1.00 93.18  ? 462 TYR A CA  1 
ATOM   2302 C C   . TYR A 1 481 ? 41.258  -14.260 39.254  1.00 98.52  ? 462 TYR A C   1 
ATOM   2303 O O   . TYR A 1 481 ? 41.532  -15.413 39.013  1.00 102.54 ? 462 TYR A O   1 
ATOM   2304 C CB  . TYR A 1 481 ? 40.163  -13.540 41.293  1.00 93.11  ? 462 TYR A CB  1 
ATOM   2305 C CG  . TYR A 1 481 ? 39.294  -14.764 41.243  1.00 97.27  ? 462 TYR A CG  1 
ATOM   2306 C CD1 . TYR A 1 481 ? 38.319  -14.905 40.283  1.00 102.22 ? 462 TYR A CD1 1 
ATOM   2307 C CD2 . TYR A 1 481 ? 39.422  -15.761 42.180  1.00 97.22  ? 462 TYR A CD2 1 
ATOM   2308 C CE1 . TYR A 1 481 ? 37.496  -16.013 40.248  1.00 103.65 ? 462 TYR A CE1 1 
ATOM   2309 C CE2 . TYR A 1 481 ? 38.612  -16.878 42.158  1.00 98.06  ? 462 TYR A CE2 1 
ATOM   2310 C CZ  . TYR A 1 481 ? 37.644  -17.004 41.189  1.00 100.63 ? 462 TYR A CZ  1 
ATOM   2311 O OH  . TYR A 1 481 ? 36.846  -18.102 41.163  1.00 95.31  ? 462 TYR A OH  1 
ATOM   2312 N N   . LYS A 1 482 ? 40.785  -13.416 38.355  1.00 96.99  ? 463 LYS A N   1 
ATOM   2313 C CA  . LYS A 1 482 ? 40.494  -13.932 37.003  1.00 101.75 ? 463 LYS A CA  1 
ATOM   2314 C C   . LYS A 1 482 ? 41.782  -14.443 36.373  1.00 102.34 ? 463 LYS A C   1 
ATOM   2315 O O   . LYS A 1 482 ? 41.765  -15.544 35.868  1.00 103.57 ? 463 LYS A O   1 
ATOM   2316 C CB  . LYS A 1 482 ? 39.829  -12.859 36.149  1.00 102.75 ? 463 LYS A CB  1 
ATOM   2317 C CG  . LYS A 1 482 ? 38.336  -12.716 36.384  1.00 106.78 ? 463 LYS A CG  1 
ATOM   2318 C CD  . LYS A 1 482 ? 37.479  -13.602 35.510  1.00 116.89 ? 463 LYS A CD  1 
ATOM   2319 C CE  . LYS A 1 482 ? 36.261  -14.154 36.219  1.00 113.82 ? 463 LYS A CE  1 
ATOM   2320 N NZ  . LYS A 1 482 ? 35.006  -13.787 35.526  1.00 115.92 ? 463 LYS A NZ  1 
ATOM   2321 N N   . GLU A 1 483 ? 42.867  -13.695 36.506  1.00 99.26  ? 464 GLU A N   1 
ATOM   2322 C CA  . GLU A 1 483 ? 44.152  -14.141 35.933  1.00 99.22  ? 464 GLU A CA  1 
ATOM   2323 C C   . GLU A 1 483 ? 44.496  -15.484 36.554  1.00 104.97 ? 464 GLU A C   1 
ATOM   2324 O O   . GLU A 1 483 ? 44.835  -16.398 35.835  1.00 107.04 ? 464 GLU A O   1 
ATOM   2325 C CB  . GLU A 1 483 ? 45.251  -13.165 36.315  1.00 98.29  ? 464 GLU A CB  1 
ATOM   2326 C CG  . GLU A 1 483 ? 45.194  -11.874 35.540  1.00 110.05 ? 464 GLU A CG  1 
ATOM   2327 C CD  . GLU A 1 483 ? 46.299  -10.919 35.938  1.00 119.00 ? 464 GLU A CD  1 
ATOM   2328 O OE1 . GLU A 1 483 ? 46.241  -9.753  35.528  1.00 118.52 ? 464 GLU A OE1 1 
ATOM   2329 O OE2 . GLU A 1 483 ? 47.197  -11.351 36.673  1.00 117.37 ? 464 GLU A OE2 1 
ATOM   2330 N N   . ALA A 1 484 ? 44.338  -15.597 37.861  1.00 99.21  ? 465 ALA A N   1 
ATOM   2331 C CA  . ALA A 1 484 ? 44.640  -16.866 38.545  1.00 92.34  ? 465 ALA A CA  1 
ATOM   2332 C C   . ALA A 1 484 ? 43.675  -17.938 38.072  1.00 94.99  ? 465 ALA A C   1 
ATOM   2333 O O   . ALA A 1 484 ? 44.057  -19.073 38.029  1.00 94.07  ? 465 ALA A O   1 
ATOM   2334 C CB  . ALA A 1 484 ? 44.533  -16.677 40.019  1.00 94.41  ? 465 ALA A CB  1 
ATOM   2335 N N   . SER A 1 485 ? 42.419  -17.579 37.858  1.00 98.92  ? 466 SER A N   1 
ATOM   2336 C CA  . SER A 1 485 ? 41.425  -18.555 37.360  1.00 103.35 ? 466 SER A CA  1 
ATOM   2337 C C   . SER A 1 485 ? 41.697  -18.925 35.902  1.00 109.18 ? 466 SER A C   1 
ATOM   2338 O O   . SER A 1 485 ? 41.303  -20.010 35.506  1.00 107.78 ? 466 SER A O   1 
ATOM   2339 C CB  . SER A 1 485 ? 40.044  -18.068 37.554  1.00 103.57 ? 466 SER A CB  1 
ATOM   2340 O OG  . SER A 1 485 ? 39.209  -19.150 37.902  1.00 103.16 ? 466 SER A OG  1 
ATOM   2341 N N   . GLU A 1 486 ? 42.336  -18.044 35.134  1.00 108.90 ? 467 GLU A N   1 
ATOM   2342 C CA  . GLU A 1 486 ? 42.639  -18.316 33.706  1.00 105.04 ? 467 GLU A CA  1 
ATOM   2343 C C   . GLU A 1 486 ? 43.538  -19.544 33.601  1.00 101.31 ? 467 GLU A C   1 
ATOM   2344 O O   . GLU A 1 486 ? 43.353  -20.285 32.658  1.00 110.73 ? 467 GLU A O   1 
ATOM   2345 C CB  . GLU A 1 486 ? 43.438  -17.193 33.046  1.00 113.45 ? 467 GLU A CB  1 
ATOM   2346 C CG  . GLU A 1 486 ? 42.712  -15.875 32.814  1.00 120.03 ? 467 GLU A CG  1 
ATOM   2347 C CD  . GLU A 1 486 ? 41.212  -15.858 32.603  1.00 125.36 ? 467 GLU A CD  1 
ATOM   2348 O OE1 . GLU A 1 486 ? 40.739  -14.944 31.912  1.00 133.81 ? 467 GLU A OE1 1 
ATOM   2349 O OE2 . GLU A 1 486 ? 40.526  -16.730 33.147  1.00 120.83 ? 467 GLU A OE2 1 
ATOM   2350 N N   . VAL A 1 487 ? 44.492  -19.735 34.508  1.00 91.58  ? 468 VAL A N   1 
ATOM   2351 C CA  . VAL A 1 487 ? 45.361  -20.929 34.376  1.00 85.51  ? 468 VAL A CA  1 
ATOM   2352 C C   . VAL A 1 487 ? 44.437  -22.121 34.516  1.00 91.11  ? 468 VAL A C   1 
ATOM   2353 O O   . VAL A 1 487 ? 44.026  -22.403 35.605  1.00 89.12  ? 468 VAL A O   1 
ATOM   2354 C CB  . VAL A 1 487 ? 46.348  -20.977 35.540  1.00 73.63  ? 468 VAL A CB  1 
ATOM   2355 C CG1 . VAL A 1 487 ? 46.717  -22.396 35.862  1.00 72.50  ? 468 VAL A CG1 1 
ATOM   2356 C CG2 . VAL A 1 487 ? 47.585  -20.172 35.258  1.00 77.77  ? 468 VAL A CG2 1 
ATOM   2357 N N   . LYS A 1 488 ? 44.231  -22.846 33.432  1.00 96.36  ? 469 LYS A N   1 
ATOM   2358 C CA  . LYS A 1 488 ? 43.296  -23.982 33.458  1.00 92.75  ? 469 LYS A CA  1 
ATOM   2359 C C   . LYS A 1 488 ? 43.929  -25.136 34.207  1.00 99.23  ? 469 LYS A C   1 
ATOM   2360 O O   . LYS A 1 488 ? 45.126  -25.278 34.153  1.00 100.65 ? 469 LYS A O   1 
ATOM   2361 C CB  . LYS A 1 488 ? 42.929  -24.381 32.034  1.00 94.53  ? 469 LYS A CB  1 
ATOM   2362 C CG  . LYS A 1 488 ? 41.761  -23.596 31.472  1.00 104.57 ? 469 LYS A CG  1 
ATOM   2363 C CD  . LYS A 1 488 ? 41.083  -22.771 32.534  1.00 115.30 ? 469 LYS A CD  1 
ATOM   2364 C CE  . LYS A 1 488 ? 40.054  -21.811 31.982  1.00 111.10 ? 469 LYS A CE  1 
ATOM   2365 N NZ  . LYS A 1 488 ? 38.918  -21.635 32.914  1.00 115.25 ? 469 LYS A NZ  1 
ATOM   2366 N N   . PRO A 1 489 ? 43.129  -25.993 34.854  1.00 96.62  ? 470 PRO A N   1 
ATOM   2367 C CA  . PRO A 1 489 ? 43.627  -27.130 35.573  1.00 93.01  ? 470 PRO A CA  1 
ATOM   2368 C C   . PRO A 1 489 ? 44.072  -28.201 34.578  1.00 101.46 ? 470 PRO A C   1 
ATOM   2369 O O   . PRO A 1 489 ? 43.586  -28.235 33.491  1.00 101.62 ? 470 PRO A O   1 
ATOM   2370 C CB  . PRO A 1 489 ? 42.394  -27.633 36.314  1.00 96.70  ? 470 PRO A CB  1 
ATOM   2371 C CG  . PRO A 1 489 ? 41.466  -26.477 36.288  1.00 88.94  ? 470 PRO A CG  1 
ATOM   2372 C CD  . PRO A 1 489 ? 41.691  -25.917 34.911  1.00 95.33  ? 470 PRO A CD  1 
ATOM   2373 N N   . PRO A 1 490 ? 44.997  -29.103 34.937  1.00 104.59 ? 471 PRO A N   1 
ATOM   2374 C CA  . PRO A 1 490 ? 45.245  -29.473 36.313  1.00 97.15  ? 471 PRO A CA  1 
ATOM   2375 C C   . PRO A 1 490 ? 46.412  -28.608 36.775  1.00 99.51  ? 471 PRO A C   1 
ATOM   2376 O O   . PRO A 1 490 ? 47.303  -28.410 36.007  1.00 92.09  ? 471 PRO A O   1 
ATOM   2377 C CB  . PRO A 1 490 ? 45.706  -30.901 36.109  1.00 91.50  ? 471 PRO A CB  1 
ATOM   2378 C CG  . PRO A 1 490 ? 46.578  -30.773 34.911  1.00 96.52  ? 471 PRO A CG  1 
ATOM   2379 C CD  . PRO A 1 490 ? 45.832  -29.828 34.009  1.00 91.72  ? 471 PRO A CD  1 
ATOM   2380 N N   . ARG A 1 491 ? 46.301  -28.058 37.980  1.00 95.54  ? 472 ARG A N   1 
ATOM   2381 C CA  . ARG A 1 491 ? 47.334  -27.132 38.478  1.00 92.53  ? 472 ARG A CA  1 
ATOM   2382 C C   . ARG A 1 491 ? 47.951  -27.673 39.751  1.00 82.78  ? 472 ARG A C   1 
ATOM   2383 O O   . ARG A 1 491 ? 47.309  -28.438 40.423  1.00 86.45  ? 472 ARG A O   1 
ATOM   2384 C CB  . ARG A 1 491 ? 46.682  -25.796 38.813  1.00 90.27  ? 472 ARG A CB  1 
ATOM   2385 C CG  . ARG A 1 491 ? 45.172  -25.844 38.952  1.00 86.75  ? 472 ARG A CG  1 
ATOM   2386 C CD  . ARG A 1 491 ? 44.673  -24.425 39.034  1.00 85.43  ? 472 ARG A CD  1 
ATOM   2387 N NE  . ARG A 1 491 ? 43.297  -24.319 39.457  1.00 90.06  ? 472 ARG A NE  1 
ATOM   2388 C CZ  . ARG A 1 491 ? 42.411  -23.567 38.842  1.00 92.39  ? 472 ARG A CZ  1 
ATOM   2389 N NH1 . ARG A 1 491 ? 42.778  -22.870 37.791  1.00 92.24  ? 472 ARG A NH1 1 
ATOM   2390 N NH2 . ARG A 1 491 ? 41.164  -23.507 39.256  1.00 90.22  ? 472 ARG A NH2 1 
ATOM   2391 N N   . ASP A 1 492 ? 49.151  -27.216 40.071  1.00 80.55  ? 473 ASP A N   1 
ATOM   2392 C CA  . ASP A 1 492 ? 49.813  -27.658 41.313  1.00 82.50  ? 473 ASP A CA  1 
ATOM   2393 C C   . ASP A 1 492 ? 49.201  -26.884 42.468  1.00 87.30  ? 473 ASP A C   1 
ATOM   2394 O O   . ASP A 1 492 ? 48.701  -25.812 42.246  1.00 94.35  ? 473 ASP A O   1 
ATOM   2395 C CB  . ASP A 1 492 ? 51.326  -27.554 41.202  1.00 82.91  ? 473 ASP A CB  1 
ATOM   2396 C CG  . ASP A 1 492 ? 51.849  -26.150 41.326  1.00 90.65  ? 473 ASP A CG  1 
ATOM   2397 O OD1 . ASP A 1 492 ? 53.057  -25.995 41.368  1.00 91.77  ? 473 ASP A OD1 1 
ATOM   2398 O OD2 . ASP A 1 492 ? 51.043  -25.248 41.377  1.00 87.65  ? 473 ASP A OD2 1 
ATOM   2399 N N   . ILE A 1 493 ? 49.378  -27.344 43.689  1.00 88.66  ? 474 ILE A N   1 
ATOM   2400 C CA  . ILE A 1 493 ? 48.632  -26.682 44.786  1.00 87.17  ? 474 ILE A CA  1 
ATOM   2401 C C   . ILE A 1 493 ? 49.010  -25.225 45.019  1.00 84.58  ? 474 ILE A C   1 
ATOM   2402 O O   . ILE A 1 493 ? 48.114  -24.511 45.399  1.00 89.94  ? 474 ILE A O   1 
ATOM   2403 C CB  . ILE A 1 493 ? 48.571  -27.533 46.048  1.00 81.81  ? 474 ILE A CB  1 
ATOM   2404 C CG1 . ILE A 1 493 ? 47.627  -28.707 45.821  1.00 94.77  ? 474 ILE A CG1 1 
ATOM   2405 C CG2 . ILE A 1 493 ? 48.092  -26.679 47.185  1.00 69.68  ? 474 ILE A CG2 1 
ATOM   2406 C CD1 . ILE A 1 493 ? 47.802  -29.401 44.484  1.00 81.80  ? 474 ILE A CD1 1 
ATOM   2407 N N   . THR A 1 494 ? 50.261  -24.805 44.881  1.00 85.13  ? 475 THR A N   1 
ATOM   2408 C CA  . THR A 1 494 ? 50.477  -23.366 45.050  1.00 86.52  ? 475 THR A CA  1 
ATOM   2409 C C   . THR A 1 494 ? 49.628  -22.566 44.061  1.00 88.02  ? 475 THR A C   1 
ATOM   2410 O O   . THR A 1 494 ? 49.205  -21.445 44.364  1.00 91.69  ? 475 THR A O   1 
ATOM   2411 C CB  . THR A 1 494 ? 51.960  -22.997 44.887  1.00 90.54  ? 475 THR A CB  1 
ATOM   2412 O OG1 . THR A 1 494 ? 52.305  -22.980 43.495  1.00 96.71  ? 475 THR A OG1 1 
ATOM   2413 C CG2 . THR A 1 494 ? 52.843  -24.004 45.597  1.00 86.22  ? 475 THR A CG2 1 
ATOM   2414 N N   . ALA A 1 495 ? 49.355  -23.124 42.885  1.00 88.57  ? 476 ALA A N   1 
ATOM   2415 C CA  . ALA A 1 495 ? 48.477  -22.458 41.933  1.00 83.82  ? 476 ALA A CA  1 
ATOM   2416 C C   . ALA A 1 495 ? 47.009  -22.616 42.301  1.00 87.35  ? 476 ALA A C   1 
ATOM   2417 O O   . ALA A 1 495 ? 46.184  -21.770 41.939  1.00 84.36  ? 476 ALA A O   1 
ATOM   2418 C CB  . ALA A 1 495 ? 48.719  -23.010 40.534  1.00 82.79  ? 476 ALA A CB  1 
ATOM   2419 N N   . GLU A 1 496 ? 46.663  -23.701 42.988  1.00 91.70  ? 477 GLU A N   1 
ATOM   2420 C CA  . GLU A 1 496 ? 45.302  -23.855 43.480  1.00 91.72  ? 477 GLU A CA  1 
ATOM   2421 C C   . GLU A 1 496 ? 45.067  -22.966 44.695  1.00 94.08  ? 477 GLU A C   1 
ATOM   2422 O O   . GLU A 1 496 ? 44.000  -22.355 44.832  1.00 94.20  ? 477 GLU A O   1 
ATOM   2423 C CB  . GLU A 1 496 ? 45.028  -25.323 43.811  1.00 86.80  ? 477 GLU A CB  1 
ATOM   2424 C CG  . GLU A 1 496 ? 43.551  -25.630 43.940  1.00 96.78  ? 477 GLU A CG  1 
ATOM   2425 C CD  . GLU A 1 496 ? 42.841  -25.652 42.599  1.00 102.33 ? 477 GLU A CD  1 
ATOM   2426 O OE1 . GLU A 1 496 ? 41.592  -25.575 42.575  1.00 108.20 ? 477 GLU A OE1 1 
ATOM   2427 O OE2 . GLU A 1 496 ? 43.529  -25.773 41.565  1.00 103.25 ? 477 GLU A OE2 1 
ATOM   2428 N N   . PHE A 1 497 ? 46.070  -22.889 45.543  1.00 91.23  ? 478 PHE A N   1 
ATOM   2429 C CA  . PHE A 1 497 ? 45.937  -22.063 46.752  1.00 88.32  ? 478 PHE A CA  1 
ATOM   2430 C C   . PHE A 1 497 ? 45.698  -20.633 46.321  1.00 94.61  ? 478 PHE A C   1 
ATOM   2431 O O   . PHE A 1 497 ? 44.883  -19.967 46.908  1.00 101.21 ? 478 PHE A O   1 
ATOM   2432 C CB  . PHE A 1 497 ? 47.252  -22.092 47.510  1.00 89.88  ? 478 PHE A CB  1 
ATOM   2433 C CG  . PHE A 1 497 ? 47.349  -21.078 48.607  1.00 96.62  ? 478 PHE A CG  1 
ATOM   2434 C CD1 . PHE A 1 497 ? 46.600  -21.209 49.750  1.00 97.31  ? 478 PHE A CD1 1 
ATOM   2435 C CD2 . PHE A 1 497 ? 48.209  -20.010 48.502  1.00 101.21 ? 478 PHE A CD2 1 
ATOM   2436 C CE1 . PHE A 1 497 ? 46.703  -20.286 50.768  1.00 101.17 ? 478 PHE A CE1 1 
ATOM   2437 C CE2 . PHE A 1 497 ? 48.309  -19.085 49.522  1.00 100.81 ? 478 PHE A CE2 1 
ATOM   2438 C CZ  . PHE A 1 497 ? 47.554  -19.226 50.650  1.00 102.63 ? 478 PHE A CZ  1 
ATOM   2439 N N   . LEU A 1 498 ? 46.385  -20.200 45.282  1.00 95.28  ? 479 LEU A N   1 
ATOM   2440 C CA  . LEU A 1 498 ? 46.258  -18.791 44.857  1.00 91.31  ? 479 LEU A CA  1 
ATOM   2441 C C   . LEU A 1 498 ? 44.833  -18.495 44.429  1.00 89.00  ? 479 LEU A C   1 
ATOM   2442 O O   . LEU A 1 498 ? 44.328  -17.462 44.772  1.00 93.77  ? 479 LEU A O   1 
ATOM   2443 C CB  . LEU A 1 498 ? 47.197  -18.561 43.684  1.00 85.19  ? 479 LEU A CB  1 
ATOM   2444 C CG  . LEU A 1 498 ? 47.047  -17.196 43.048  1.00 85.35  ? 479 LEU A CG  1 
ATOM   2445 C CD1 . LEU A 1 498 ? 47.783  -16.175 43.870  1.00 95.95  ? 479 LEU A CD1 1 
ATOM   2446 C CD2 . LEU A 1 498 ? 47.591  -17.206 41.647  1.00 81.60  ? 479 LEU A CD2 1 
ATOM   2447 N N   . VAL A 1 499 ? 44.215  -19.374 43.673  1.00 91.80  ? 480 VAL A N   1 
ATOM   2448 C CA  . VAL A 1 499 ? 42.829  -19.038 43.277  1.00 94.47  ? 480 VAL A CA  1 
ATOM   2449 C C   . VAL A 1 499 ? 41.975  -19.025 44.529  1.00 94.79  ? 480 VAL A C   1 
ATOM   2450 O O   . VAL A 1 499 ? 41.207  -18.113 44.704  1.00 97.32  ? 480 VAL A O   1 
ATOM   2451 C CB  . VAL A 1 499 ? 42.275  -20.049 42.273  1.00 95.67  ? 480 VAL A CB  1 
ATOM   2452 C CG1 . VAL A 1 499 ? 40.783  -20.184 42.441  1.00 97.14  ? 480 VAL A CG1 1 
ATOM   2453 C CG2 . VAL A 1 499 ? 42.593  -19.627 40.858  1.00 96.25  ? 480 VAL A CG2 1 
ATOM   2454 N N   . LYS A 1 500 ? 42.137  -20.013 45.386  1.00 95.63  ? 481 LYS A N   1 
ATOM   2455 C CA  . LYS A 1 500 ? 41.291  -20.009 46.591  1.00 98.94  ? 481 LYS A CA  1 
ATOM   2456 C C   . LYS A 1 500 ? 41.630  -18.784 47.430  1.00 100.18 ? 481 LYS A C   1 
ATOM   2457 O O   . LYS A 1 500 ? 40.713  -18.097 47.839  1.00 101.62 ? 481 LYS A O   1 
ATOM   2458 C CB  . LYS A 1 500 ? 41.502  -21.308 47.361  1.00 100.66 ? 481 LYS A CB  1 
ATOM   2459 C CG  . LYS A 1 500 ? 40.981  -22.552 46.662  1.00 102.80 ? 481 LYS A CG  1 
ATOM   2460 C CD  . LYS A 1 500 ? 40.139  -23.419 47.553  1.00 105.78 ? 481 LYS A CD  1 
ATOM   2461 C CE  . LYS A 1 500 ? 40.104  -24.860 47.106  1.00 111.24 ? 481 LYS A CE  1 
ATOM   2462 N NZ  . LYS A 1 500 ? 39.127  -25.057 46.015  1.00 115.89 ? 481 LYS A NZ  1 
ATOM   2463 N N   . SER A 1 501 ? 42.908  -18.479 47.592  1.00 96.75  ? 482 SER A N   1 
ATOM   2464 C CA  . SER A 1 501 ? 43.263  -17.333 48.454  1.00 94.01  ? 482 SER A CA  1 
ATOM   2465 C C   . SER A 1 501 ? 42.674  -16.062 47.875  1.00 97.61  ? 482 SER A C   1 
ATOM   2466 O O   . SER A 1 501 ? 42.036  -15.350 48.597  1.00 106.80 ? 482 SER A O   1 
ATOM   2467 C CB  . SER A 1 501 ? 44.741  -17.230 48.583  1.00 99.14  ? 482 SER A CB  1 
ATOM   2468 O OG  . SER A 1 501 ? 45.214  -15.908 48.393  1.00 108.25 ? 482 SER A OG  1 
ATOM   2469 N N   . LYS A 1 502 ? 42.814  -15.850 46.580  1.00 95.36  ? 483 LYS A N   1 
ATOM   2470 C CA  . LYS A 1 502 ? 42.269  -14.602 46.010  1.00 93.13  ? 483 LYS A CA  1 
ATOM   2471 C C   . LYS A 1 502 ? 40.760  -14.620 46.177  1.00 93.00  ? 483 LYS A C   1 
ATOM   2472 O O   . LYS A 1 502 ? 40.211  -13.622 46.573  1.00 99.34  ? 483 LYS A O   1 
ATOM   2473 C CB  . LYS A 1 502 ? 42.648  -14.471 44.540  1.00 93.43  ? 483 LYS A CB  1 
ATOM   2474 C CG  . LYS A 1 502 ? 44.117  -14.221 44.271  1.00 90.51  ? 483 LYS A CG  1 
ATOM   2475 C CD  . LYS A 1 502 ? 44.723  -13.229 45.209  1.00 100.46 ? 483 LYS A CD  1 
ATOM   2476 C CE  . LYS A 1 502 ? 45.712  -12.310 44.531  1.00 103.03 ? 483 LYS A CE  1 
ATOM   2477 N NZ  . LYS A 1 502 ? 46.897  -12.048 45.379  1.00 100.76 ? 483 LYS A NZ  1 
ATOM   2478 N N   . HIS A 1 503 ? 40.127  -15.754 45.939  1.00 95.01  ? 484 HIS A N   1 
ATOM   2479 C CA  . HIS A 1 503 ? 38.660  -15.793 46.082  1.00 102.78 ? 484 HIS A CA  1 
ATOM   2480 C C   . HIS A 1 503 ? 38.281  -15.474 47.513  1.00 103.77 ? 484 HIS A C   1 
ATOM   2481 O O   . HIS A 1 503 ? 37.380  -14.693 47.714  1.00 107.22 ? 484 HIS A O   1 
ATOM   2482 C CB  . HIS A 1 503 ? 38.181  -17.209 45.841  1.00 109.33 ? 484 HIS A CB  1 
ATOM   2483 C CG  . HIS A 1 503 ? 36.726  -17.357 46.066  1.00 110.84 ? 484 HIS A CG  1 
ATOM   2484 N ND1 . HIS A 1 503 ? 35.811  -17.047 45.104  1.00 112.46 ? 484 HIS A ND1 1 
ATOM   2485 C CD2 . HIS A 1 503 ? 36.036  -17.774 47.137  1.00 110.90 ? 484 HIS A CD2 1 
ATOM   2486 C CE1 . HIS A 1 503 ? 34.607  -17.278 45.561  1.00 119.16 ? 484 HIS A CE1 1 
ATOM   2487 N NE2 . HIS A 1 503 ? 34.720  -17.719 46.803  1.00 126.06 ? 484 HIS A NE2 1 
ATOM   2488 N N   . ARG A 1 504 ? 38.975  -16.056 48.470  1.00 104.27 ? 485 ARG A N   1 
ATOM   2489 C CA  . ARG A 1 504 ? 38.584  -15.770 49.860  1.00 104.93 ? 485 ARG A CA  1 
ATOM   2490 C C   . ARG A 1 504 ? 38.785  -14.291 50.143  1.00 104.50 ? 485 ARG A C   1 
ATOM   2491 O O   . ARG A 1 504 ? 37.863  -13.662 50.629  1.00 107.00 ? 485 ARG A O   1 
ATOM   2492 C CB  . ARG A 1 504 ? 39.525  -16.512 50.795  1.00 106.18 ? 485 ARG A CB  1 
ATOM   2493 C CG  . ARG A 1 504 ? 39.340  -16.117 52.244  1.00 110.71 ? 485 ARG A CG  1 
ATOM   2494 C CD  . ARG A 1 504 ? 40.385  -15.121 52.654  1.00 112.31 ? 485 ARG A CD  1 
ATOM   2495 N NE  . ARG A 1 504 ? 40.032  -14.731 53.999  1.00 122.28 ? 485 ARG A NE  1 
ATOM   2496 C CZ  . ARG A 1 504 ? 40.130  -13.508 54.466  1.00 117.04 ? 485 ARG A CZ  1 
ATOM   2497 N NH1 . ARG A 1 504 ? 40.593  -12.544 53.697  1.00 106.80 ? 485 ARG A NH1 1 
ATOM   2498 N NH2 . ARG A 1 504 ? 39.773  -13.256 55.705  1.00 123.54 ? 485 ARG A NH2 1 
ATOM   2499 N N   . ASP A 1 505 ? 39.924  -13.755 49.745  1.00 104.54 ? 486 ASP A N   1 
ATOM   2500 C CA  . ASP A 1 505 ? 40.202  -12.337 50.039  1.00 101.94 ? 486 ASP A CA  1 
ATOM   2501 C C   . ASP A 1 505 ? 39.145  -11.472 49.383  1.00 100.78 ? 486 ASP A C   1 
ATOM   2502 O O   . ASP A 1 505 ? 38.577  -10.652 50.061  1.00 108.58 ? 486 ASP A O   1 
ATOM   2503 C CB  . ASP A 1 505 ? 41.532  -11.897 49.449  1.00 102.66 ? 486 ASP A CB  1 
ATOM   2504 C CG  . ASP A 1 505 ? 42.719  -12.517 50.140  1.00 106.89 ? 486 ASP A CG  1 
ATOM   2505 O OD1 . ASP A 1 505 ? 42.501  -13.398 50.959  1.00 109.70 ? 486 ASP A OD1 1 
ATOM   2506 O OD2 . ASP A 1 505 ? 43.841  -12.105 49.848  1.00 105.87 ? 486 ASP A OD2 1 
ATOM   2507 N N   . LEU A 1 506 ? 38.845  -11.720 48.123  1.00 103.57 ? 487 LEU A N   1 
ATOM   2508 C CA  . LEU A 1 506 ? 37.948  -10.789 47.453  1.00 103.81 ? 487 LEU A CA  1 
ATOM   2509 C C   . LEU A 1 506 ? 36.564  -10.794 48.087  1.00 106.31 ? 487 LEU A C   1 
ATOM   2510 O O   . LEU A 1 506 ? 35.942  -9.735  48.220  1.00 108.21 ? 487 LEU A O   1 
ATOM   2511 C CB  . LEU A 1 506 ? 37.877  -11.103 45.960  1.00 98.98  ? 487 LEU A CB  1 
ATOM   2512 C CG  . LEU A 1 506 ? 36.972  -10.158 45.183  1.00 99.68  ? 487 LEU A CG  1 
ATOM   2513 C CD1 . LEU A 1 506 ? 37.637  -9.804  43.898  1.00 102.97 ? 487 LEU A CD1 1 
ATOM   2514 C CD2 . LEU A 1 506 ? 35.615  -10.811 44.921  1.00 103.19 ? 487 LEU A CD2 1 
ATOM   2515 N N   . THR A 1 507 ? 36.053  -11.965 48.479  1.00 107.05 ? 488 THR A N   1 
ATOM   2516 C CA  . THR A 1 507 ? 34.757  -11.969 49.155  1.00 110.35 ? 488 THR A CA  1 
ATOM   2517 C C   . THR A 1 507 ? 34.854  -11.318 50.533  1.00 113.69 ? 488 THR A C   1 
ATOM   2518 O O   . THR A 1 507 ? 33.865  -10.757 51.022  1.00 114.92 ? 488 THR A O   1 
ATOM   2519 C CB  . THR A 1 507 ? 34.192  -13.387 49.272  1.00 103.86 ? 488 THR A CB  1 
ATOM   2520 O OG1 . THR A 1 507 ? 35.195  -14.269 49.785  1.00 104.51 ? 488 THR A OG1 1 
ATOM   2521 C CG2 . THR A 1 507 ? 33.708  -13.882 47.922  1.00 106.21 ? 488 THR A CG2 1 
ATOM   2522 N N   . ALA A 1 508 ? 36.037  -11.360 51.161  1.00 110.05 ? 489 ALA A N   1 
ATOM   2523 C CA  . ALA A 1 508 ? 36.262  -10.607 52.391  1.00 102.66 ? 489 ALA A CA  1 
ATOM   2524 C C   . ALA A 1 508 ? 36.109  -9.106  52.154  1.00 108.58 ? 489 ALA A C   1 
ATOM   2525 O O   . ALA A 1 508 ? 35.399  -8.418  52.894  1.00 116.84 ? 489 ALA A O   1 
ATOM   2526 C CB  . ALA A 1 508 ? 37.646  -10.928 52.957  1.00 97.16  ? 489 ALA A CB  1 
ATOM   2527 N N   . LEU A 1 509 ? 36.771  -8.576  51.125  1.00 107.89 ? 490 LEU A N   1 
ATOM   2528 C CA  . LEU A 1 509 ? 36.608  -7.160  50.821  1.00 105.80 ? 490 LEU A CA  1 
ATOM   2529 C C   . LEU A 1 509 ? 35.201  -6.840  50.345  1.00 109.65 ? 490 LEU A C   1 
ATOM   2530 O O   . LEU A 1 509 ? 34.702  -5.746  50.604  1.00 115.69 ? 490 LEU A O   1 
ATOM   2531 C CB  . LEU A 1 509 ? 37.621  -6.713  49.773  1.00 104.41 ? 490 LEU A CB  1 
ATOM   2532 C CG  . LEU A 1 509 ? 39.083  -6.856  50.164  1.00 104.52 ? 490 LEU A CG  1 
ATOM   2533 C CD1 . LEU A 1 509 ? 39.900  -5.949  49.252  1.00 106.16 ? 490 LEU A CD1 1 
ATOM   2534 C CD2 . LEU A 1 509 ? 39.290  -6.528  51.635  1.00 106.72 ? 490 LEU A CD2 1 
ATOM   2535 N N   . CYS A 1 510 ? 34.544  -7.761  49.643  1.00 113.23 ? 491 CYS A N   1 
ATOM   2536 C CA  . CYS A 1 510 ? 33.153  -7.526  49.277  1.00 117.66 ? 491 CYS A CA  1 
ATOM   2537 C C   . CYS A 1 510 ? 32.230  -7.523  50.495  1.00 117.50 ? 491 CYS A C   1 
ATOM   2538 O O   . CYS A 1 510 ? 31.121  -6.981  50.422  1.00 120.34 ? 491 CYS A O   1 
ATOM   2539 C CB  . CYS A 1 510 ? 32.700  -8.571  48.257  1.00 119.41 ? 491 CYS A CB  1 
ATOM   2540 S SG  . CYS A 1 510 ? 33.461  -8.363  46.640  1.00 122.10 ? 491 CYS A SG  1 
ATOM   2541 N N   . LYS A 1 511 ? 32.662  -8.120  51.603  1.00 115.40 ? 492 LYS A N   1 
ATOM   2542 C CA  . LYS A 1 511 ? 31.970  -8.048  52.888  1.00 120.02 ? 492 LYS A CA  1 
ATOM   2543 C C   . LYS A 1 511 ? 32.161  -6.703  53.576  1.00 120.77 ? 492 LYS A C   1 
ATOM   2544 O O   . LYS A 1 511 ? 31.201  -6.149  54.113  1.00 122.16 ? 492 LYS A O   1 
ATOM   2545 C CB  . LYS A 1 511 ? 32.466  -9.227  53.763  1.00 115.26 ? 492 LYS A CB  1 
ATOM   2546 C CG  . LYS A 1 511 ? 31.814  -9.479  55.116  1.00 118.54 ? 492 LYS A CG  1 
ATOM   2547 C CD  . LYS A 1 511 ? 32.417  -10.746 55.743  1.00 122.60 ? 492 LYS A CD  1 
ATOM   2548 C CE  . LYS A 1 511 ? 31.779  -11.171 57.055  1.00 128.10 ? 492 LYS A CE  1 
ATOM   2549 N NZ  . LYS A 1 511 ? 32.103  -10.278 58.170  1.00 123.75 ? 492 LYS A NZ  1 
ATOM   2550 N N   . GLU A 1 512 ? 33.372  -6.160  53.541  1.00 118.71 ? 493 GLU A N   1 
ATOM   2551 C CA  . GLU A 1 512 ? 33.603  -4.810  54.045  1.00 117.32 ? 493 GLU A CA  1 
ATOM   2552 C C   . GLU A 1 512 ? 32.754  -3.785  53.303  1.00 115.58 ? 493 GLU A C   1 
ATOM   2553 O O   . GLU A 1 512 ? 31.998  -3.024  53.917  1.00 122.87 ? 493 GLU A O   1 
ATOM   2554 C CB  . GLU A 1 512 ? 35.082  -4.444  53.921  1.00 116.71 ? 493 GLU A CB  1 
ATOM   2555 C CG  . GLU A 1 512 ? 35.985  -5.049  54.963  1.00 123.54 ? 493 GLU A CG  1 
ATOM   2556 C CD  . GLU A 1 512 ? 37.078  -4.073  55.338  1.00 136.58 ? 493 GLU A CD  1 
ATOM   2557 O OE1 . GLU A 1 512 ? 36.766  -2.865  55.465  1.00 137.84 ? 493 GLU A OE1 1 
ATOM   2558 O OE2 . GLU A 1 512 ? 38.245  -4.506  55.483  1.00 139.74 ? 493 GLU A OE2 1 
ATOM   2559 N N   . TYR A 1 513 ? 32.864  -3.753  51.973  1.00 113.70 ? 494 TYR A N   1 
ATOM   2560 C CA  . TYR A 1 513 ? 32.130  -2.771  51.182  1.00 111.97 ? 494 TYR A CA  1 
ATOM   2561 C C   . TYR A 1 513 ? 30.624  -2.927  51.334  1.00 116.77 ? 494 TYR A C   1 
ATOM   2562 O O   . TYR A 1 513 ? 29.885  -1.969  51.093  1.00 121.49 ? 494 TYR A O   1 
ATOM   2563 C CB  . TYR A 1 513 ? 32.533  -2.870  49.706  1.00 101.44 ? 494 TYR A CB  1 
ATOM   2564 C CG  . TYR A 1 513 ? 31.850  -1.884  48.781  1.00 95.19  ? 494 TYR A CG  1 
ATOM   2565 C CD1 . TYR A 1 513 ? 32.496  -0.732  48.373  1.00 96.36  ? 494 TYR A CD1 1 
ATOM   2566 C CD2 . TYR A 1 513 ? 30.574  -2.120  48.293  1.00 99.50  ? 494 TYR A CD2 1 
ATOM   2567 C CE1 . TYR A 1 513 ? 31.881  0.169   47.520  1.00 95.37  ? 494 TYR A CE1 1 
ATOM   2568 C CE2 . TYR A 1 513 ? 29.950  -1.224  47.449  1.00 100.02 ? 494 TYR A CE2 1 
ATOM   2569 C CZ  . TYR A 1 513 ? 30.607  -0.083  47.059  1.00 96.02  ? 494 TYR A CZ  1 
ATOM   2570 O OH  . TYR A 1 513 ? 29.987  0.807   46.200  1.00 97.78  ? 494 TYR A OH  1 
ATOM   2571 N N   . ASP A 1 514 ? 30.139  -4.093  51.741  1.00 117.98 ? 495 ASP A N   1 
ATOM   2572 C CA  . ASP A 1 514 ? 28.707  -4.181  51.996  1.00 123.32 ? 495 ASP A CA  1 
ATOM   2573 C C   . ASP A 1 514 ? 28.349  -3.594  53.363  1.00 124.38 ? 495 ASP A C   1 
ATOM   2574 O O   . ASP A 1 514 ? 27.376  -2.833  53.478  1.00 119.76 ? 495 ASP A O   1 
ATOM   2575 C CB  . ASP A 1 514 ? 28.251  -5.633  51.843  1.00 127.32 ? 495 ASP A CB  1 
ATOM   2576 C CG  . ASP A 1 514 ? 28.136  -6.041  50.381  1.00 131.59 ? 495 ASP A CG  1 
ATOM   2577 O OD1 . ASP A 1 514 ? 28.065  -5.106  49.550  1.00 126.05 ? 495 ASP A OD1 1 
ATOM   2578 O OD2 . ASP A 1 514 ? 28.119  -7.261  50.063  1.00 128.29 ? 495 ASP A OD2 1 
ATOM   2579 N N   . GLU A 1 515 ? 29.142  -3.912  54.397  1.00 123.95 ? 496 GLU A N   1 
ATOM   2580 C CA  . GLU A 1 515 ? 28.989  -3.260  55.697  1.00 121.33 ? 496 GLU A CA  1 
ATOM   2581 C C   . GLU A 1 515 ? 29.090  -1.745  55.569  1.00 125.56 ? 496 GLU A C   1 
ATOM   2582 O O   . GLU A 1 515 ? 28.334  -1.007  56.218  1.00 129.64 ? 496 GLU A O   1 
ATOM   2583 C CB  . GLU A 1 515 ? 30.050  -3.772  56.675  1.00 121.73 ? 496 GLU A CB  1 
ATOM   2584 C CG  . GLU A 1 515 ? 29.868  -5.217  57.142  1.00 130.90 ? 496 GLU A CG  1 
ATOM   2585 C CD  . GLU A 1 515 ? 31.022  -5.699  58.027  1.00 138.06 ? 496 GLU A CD  1 
ATOM   2586 O OE1 . GLU A 1 515 ? 32.008  -4.937  58.191  1.00 136.85 ? 496 GLU A OE1 1 
ATOM   2587 O OE2 . GLU A 1 515 ? 30.945  -6.838  58.555  1.00 137.45 ? 496 GLU A OE2 1 
ATOM   2588 N N   . LEU A 1 516 ? 30.015  -1.261  54.738  1.00 123.04 ? 497 LEU A N   1 
ATOM   2589 C CA  . LEU A 1 516 ? 30.226  0.175   54.614  1.00 117.92 ? 497 LEU A CA  1 
ATOM   2590 C C   . LEU A 1 516 ? 29.236  0.854   53.686  1.00 119.30 ? 497 LEU A C   1 
ATOM   2591 O O   . LEU A 1 516 ? 29.360  2.057   53.481  1.00 124.73 ? 497 LEU A O   1 
ATOM   2592 C CB  . LEU A 1 516 ? 31.646  0.498   54.135  1.00 113.96 ? 497 LEU A CB  1 
ATOM   2593 C CG  . LEU A 1 516 ? 32.825  -0.031  54.961  1.00 123.16 ? 497 LEU A CG  1 
ATOM   2594 C CD1 . LEU A 1 516 ? 34.076  0.804   54.685  1.00 119.83 ? 497 LEU A CD1 1 
ATOM   2595 C CD2 . LEU A 1 516 ? 32.537  -0.128  56.466  1.00 118.08 ? 497 LEU A CD2 1 
ATOM   2596 N N   . ALA A 1 517 ? 28.273  0.144   53.108  1.00 120.20 ? 498 ALA A N   1 
ATOM   2597 C CA  . ALA A 1 517 ? 27.217  0.817   52.368  1.00 121.57 ? 498 ALA A CA  1 
ATOM   2598 C C   . ALA A 1 517 ? 25.863  0.667   53.030  1.00 122.09 ? 498 ALA A C   1 
ATOM   2599 O O   . ALA A 1 517 ? 24.895  1.287   52.569  1.00 118.94 ? 498 ALA A O   1 
ATOM   2600 C CB  . ALA A 1 517 ? 27.145  0.320   50.917  1.00 120.90 ? 498 ALA A CB  1 
ATOM   2601 N N   . GLU A 1 518 ? 25.853  -0.121  54.093  1.00 124.07 ? 499 GLU A N   1 
ATOM   2602 C CA  . GLU A 1 518 ? 24.658  -0.140  54.955  1.00 130.98 ? 499 GLU A CA  1 
ATOM   2603 C C   . GLU A 1 518 ? 24.824  1.140   55.767  1.00 128.65 ? 499 GLU A C   1 
ATOM   2604 O O   . GLU A 1 518 ? 23.940  1.989   55.751  1.00 126.74 ? 499 GLU A O   1 
ATOM   2605 C CB  . GLU A 1 518 ? 24.673  -1.362  55.867  1.00 132.02 ? 499 GLU A CB  1 
ATOM   2606 C CG  . GLU A 1 518 ? 23.565  -2.344  55.546  1.00 139.83 ? 499 GLU A CG  1 
ATOM   2607 C CD  . GLU A 1 518 ? 23.384  -3.461  56.555  1.00 150.18 ? 499 GLU A CD  1 
ATOM   2608 O OE1 . GLU A 1 518 ? 24.101  -3.456  57.573  1.00 145.56 ? 499 GLU A OE1 1 
ATOM   2609 O OE2 . GLU A 1 518 ? 22.523  -4.332  56.318  1.00 150.39 ? 499 GLU A OE2 1 
ATOM   2610 N N   . THR A 1 519 ? 26.039  1.358   56.256  1.00 123.63 ? 500 THR A N   1 
ATOM   2611 C CA  . THR A 1 519 ? 26.349  2.565   57.046  1.00 118.47 ? 500 THR A CA  1 
ATOM   2612 C C   . THR A 1 519 ? 26.085  3.797   56.192  1.00 116.98 ? 500 THR A C   1 
ATOM   2613 O O   . THR A 1 519 ? 25.451  4.702   56.678  1.00 121.76 ? 500 THR A O   1 
ATOM   2614 C CB  . THR A 1 519 ? 27.818  2.557   57.435  1.00 114.95 ? 500 THR A CB  1 
ATOM   2615 O OG1 . THR A 1 519 ? 27.911  1.711   58.575  1.00 115.99 ? 500 THR A OG1 1 
ATOM   2616 C CG2 . THR A 1 519 ? 28.326  3.940   57.751  1.00 110.12 ? 500 THR A CG2 1 
ATOM   2617 N N   . GLN A 1 520 ? 26.445  3.787   54.917  1.00 118.42 ? 501 GLN A N   1 
ATOM   2618 C CA  . GLN A 1 520 ? 26.143  4.961   54.064  1.00 121.05 ? 501 GLN A CA  1 
ATOM   2619 C C   . GLN A 1 520 ? 24.626  5.159   54.001  1.00 126.56 ? 501 GLN A C   1 
ATOM   2620 O O   . GLN A 1 520 ? 24.200  6.306   54.005  1.00 125.91 ? 501 GLN A O   1 
ATOM   2621 C CB  . GLN A 1 520 ? 26.849  4.879   52.710  1.00 119.17 ? 501 GLN A CB  1 
ATOM   2622 C CG  . GLN A 1 520 ? 25.964  4.471   51.548  1.00 126.21 ? 501 GLN A CG  1 
ATOM   2623 C CD  . GLN A 1 520 ? 26.115  5.373   50.354  1.00 124.88 ? 501 GLN A CD  1 
ATOM   2624 O OE1 . GLN A 1 520 ? 26.543  6.504   50.470  1.00 113.85 ? 501 GLN A OE1 1 
ATOM   2625 N NE2 . GLN A 1 520 ? 25.751  4.876   49.190  1.00 131.22 ? 501 GLN A NE2 1 
ATOM   2626 N N   . GLY A 1 521 ? 23.828  4.095   53.942  1.00 127.38 ? 502 GLY A N   1 
ATOM   2627 C CA  . GLY A 1 521 ? 22.378  4.312   53.931  1.00 128.90 ? 502 GLY A CA  1 
ATOM   2628 C C   . GLY A 1 521 ? 21.943  5.001   55.204  1.00 128.81 ? 502 GLY A C   1 
ATOM   2629 O O   . GLY A 1 521 ? 21.158  5.927   55.105  1.00 131.29 ? 502 GLY A O   1 
ATOM   2630 N N   . LYS A 1 522 ? 22.473  4.607   56.359  1.00 126.36 ? 503 LYS A N   1 
ATOM   2631 C CA  . LYS A 1 522 ? 22.024  5.269   57.602  1.00 125.22 ? 503 LYS A CA  1 
ATOM   2632 C C   . LYS A 1 522 ? 22.370  6.750   57.535  1.00 131.75 ? 503 LYS A C   1 
ATOM   2633 O O   . LYS A 1 522 ? 21.498  7.575   57.751  1.00 133.72 ? 503 LYS A O   1 
ATOM   2634 C CB  . LYS A 1 522 ? 22.877  4.808   58.778  1.00 123.53 ? 503 LYS A CB  1 
ATOM   2635 C CG  . LYS A 1 522 ? 22.804  3.336   59.132  1.00 120.46 ? 503 LYS A CG  1 
ATOM   2636 C CD  . LYS A 1 522 ? 23.691  3.020   60.309  1.00 124.71 ? 503 LYS A CD  1 
ATOM   2637 C CE  . LYS A 1 522 ? 24.447  4.232   60.811  1.00 129.29 ? 503 LYS A CE  1 
ATOM   2638 N NZ  . LYS A 1 522 ? 25.316  3.910   61.965  1.00 124.21 ? 503 LYS A NZ  1 
ATOM   2639 N N   . LEU A 1 523 ? 23.590  7.079   57.139  1.00 129.82 ? 504 LEU A N   1 
ATOM   2640 C CA  . LEU A 1 523 ? 23.956  8.512   57.116  1.00 118.57 ? 504 LEU A CA  1 
ATOM   2641 C C   . LEU A 1 523 ? 23.120  9.249   56.085  1.00 117.65 ? 504 LEU A C   1 
ATOM   2642 O O   . LEU A 1 523 ? 22.730  10.359  56.358  1.00 124.89 ? 504 LEU A O   1 
ATOM   2643 C CB  . LEU A 1 523 ? 25.456  8.650   56.894  1.00 112.18 ? 504 LEU A CB  1 
ATOM   2644 C CG  . LEU A 1 523 ? 26.268  7.975   57.989  1.00 119.67 ? 504 LEU A CG  1 
ATOM   2645 C CD1 . LEU A 1 523 ? 27.381  8.870   58.480  1.00 117.44 ? 504 LEU A CD1 1 
ATOM   2646 C CD2 . LEU A 1 523 ? 25.366  7.598   59.145  1.00 125.44 ? 504 LEU A CD2 1 
ATOM   2647 N N   . GLU A 1 524 ? 22.837  8.631   54.953  1.00 122.11 ? 505 GLU A N   1 
ATOM   2648 C CA  . GLU A 1 524 ? 22.047  9.350   53.935  1.00 131.05 ? 505 GLU A CA  1 
ATOM   2649 C C   . GLU A 1 524 ? 20.682  9.713   54.519  1.00 129.13 ? 505 GLU A C   1 
ATOM   2650 O O   . GLU A 1 524 ? 20.224  10.812  54.246  1.00 124.33 ? 505 GLU A O   1 
ATOM   2651 C CB  . GLU A 1 524 ? 21.891  8.463   52.705  1.00 133.46 ? 505 GLU A CB  1 
ATOM   2652 C CG  . GLU A 1 524 ? 23.124  8.417   51.828  1.00 130.38 ? 505 GLU A CG  1 
ATOM   2653 C CD  . GLU A 1 524 ? 22.810  8.068   50.388  1.00 133.88 ? 505 GLU A CD  1 
ATOM   2654 O OE1 . GLU A 1 524 ? 22.184  7.029   50.167  1.00 134.90 ? 505 GLU A OE1 1 
ATOM   2655 O OE2 . GLU A 1 524 ? 23.180  8.843   49.500  1.00 127.96 ? 505 GLU A OE2 1 
ATOM   2656 N N   . GLU A 1 525 ? 20.024  8.800   55.232  1.00 127.98 ? 506 GLU A N   1 
ATOM   2657 C CA  . GLU A 1 525 ? 18.712  9.153   55.835  1.00 132.08 ? 506 GLU A CA  1 
ATOM   2658 C C   . GLU A 1 525 ? 18.899  10.112  57.009  1.00 135.06 ? 506 GLU A C   1 
ATOM   2659 O O   . GLU A 1 525 ? 18.135  11.062  57.116  1.00 135.23 ? 506 GLU A O   1 
ATOM   2660 C CB  . GLU A 1 525 ? 17.827  7.935   56.093  1.00 130.39 ? 506 GLU A CB  1 
ATOM   2661 C CG  . GLU A 1 525 ? 18.539  6.792   56.766  1.00 136.71 ? 506 GLU A CG  1 
ATOM   2662 C CD  . GLU A 1 525 ? 18.407  6.857   58.272  1.00 145.54 ? 506 GLU A CD  1 
ATOM   2663 O OE1 . GLU A 1 525 ? 18.693  7.937   58.837  1.00 144.23 ? 506 GLU A OE1 1 
ATOM   2664 O OE2 . GLU A 1 525 ? 18.005  5.836   58.863  1.00 146.43 ? 506 GLU A OE2 1 
ATOM   2665 N N   . LYS A 1 526 ? 19.947  9.926   57.807  1.00 130.38 ? 507 LYS A N   1 
ATOM   2666 C CA  . LYS A 1 526 ? 20.156  10.819  58.974  1.00 122.36 ? 507 LYS A CA  1 
ATOM   2667 C C   . LYS A 1 526 ? 20.317  12.250  58.473  1.00 125.46 ? 507 LYS A C   1 
ATOM   2668 O O   . LYS A 1 526 ? 19.659  13.120  58.994  1.00 131.85 ? 507 LYS A O   1 
ATOM   2669 C CB  . LYS A 1 526 ? 21.400  10.381  59.737  1.00 117.91 ? 507 LYS A CB  1 
ATOM   2670 C CG  . LYS A 1 526 ? 21.763  11.233  60.936  1.00 120.13 ? 507 LYS A CG  1 
ATOM   2671 C CD  . LYS A 1 526 ? 22.875  10.608  61.746  1.00 122.39 ? 507 LYS A CD  1 
ATOM   2672 C CE  . LYS A 1 526 ? 22.975  11.136  63.160  1.00 126.05 ? 507 LYS A CE  1 
ATOM   2673 N NZ  . LYS A 1 526 ? 24.368  11.106  63.664  1.00 125.35 ? 507 LYS A NZ  1 
ATOM   2674 N N   . LEU A 1 527 ? 21.073  12.452  57.400  1.00 125.40 ? 508 LEU A N   1 
ATOM   2675 C CA  . LEU A 1 527 ? 21.224  13.790  56.784  1.00 129.00 ? 508 LEU A CA  1 
ATOM   2676 C C   . LEU A 1 527 ? 19.850  14.247  56.295  1.00 131.93 ? 508 LEU A C   1 
ATOM   2677 O O   . LEU A 1 527 ? 19.544  15.412  56.438  1.00 139.52 ? 508 LEU A O   1 
ATOM   2678 C CB  . LEU A 1 527 ? 22.178  13.674  55.594  1.00 122.67 ? 508 LEU A CB  1 
ATOM   2679 C CG  . LEU A 1 527 ? 23.671  13.811  55.879  1.00 118.82 ? 508 LEU A CG  1 
ATOM   2680 C CD1 . LEU A 1 527 ? 24.238  15.022  55.171  1.00 123.52 ? 508 LEU A CD1 1 
ATOM   2681 C CD2 . LEU A 1 527 ? 23.970  13.878  57.361  1.00 115.21 ? 508 LEU A CD2 1 
ATOM   2682 N N   . GLN A 1 528 ? 19.048  13.351  55.730  1.00 129.57 ? 509 GLN A N   1 
ATOM   2683 C CA  . GLN A 1 528 ? 17.712  13.740  55.227  1.00 135.35 ? 509 GLN A CA  1 
ATOM   2684 C C   . GLN A 1 528 ? 16.849  14.254  56.385  1.00 137.10 ? 509 GLN A C   1 
ATOM   2685 O O   . GLN A 1 528 ? 16.086  15.188  56.162  1.00 138.45 ? 509 GLN A O   1 
ATOM   2686 C CB  . GLN A 1 528 ? 17.074  12.566  54.484  1.00 134.83 ? 509 GLN A CB  1 
ATOM   2687 C CG  . GLN A 1 528 ? 16.162  12.988  53.347  1.00 138.10 ? 509 GLN A CG  1 
ATOM   2688 C CD  . GLN A 1 528 ? 15.540  14.322  53.661  1.00 144.50 ? 509 GLN A CD  1 
ATOM   2689 O OE1 . GLN A 1 528 ? 14.377  14.417  54.035  1.00 144.13 ? 509 GLN A OE1 1 
ATOM   2690 N NE2 . GLN A 1 528 ? 16.333  15.369  53.529  1.00 139.98 ? 509 GLN A NE2 1 
ATOM   2691 N N   . GLU A 1 529 ? 16.929  13.652  57.568  1.00 131.93 ? 510 GLU A N   1 
ATOM   2692 C CA  . GLU A 1 529 ? 16.086  14.171  58.666  1.00 132.36 ? 510 GLU A CA  1 
ATOM   2693 C C   . GLU A 1 529 ? 16.487  15.607  58.952  1.00 132.82 ? 510 GLU A C   1 
ATOM   2694 O O   . GLU A 1 529 ? 15.646  16.505  58.858  1.00 129.14 ? 510 GLU A O   1 
ATOM   2695 C CB  . GLU A 1 529 ? 16.576  13.574  59.979  1.00 128.76 ? 510 GLU A CB  1 
ATOM   2696 C CG  . GLU A 1 529 ? 15.929  12.267  60.360  1.00 139.55 ? 510 GLU A CG  1 
ATOM   2697 C CD  . GLU A 1 529 ? 14.427  12.235  60.192  1.00 146.99 ? 510 GLU A CD  1 
ATOM   2698 O OE1 . GLU A 1 529 ? 13.960  12.566  59.095  1.00 147.56 ? 510 GLU A OE1 1 
ATOM   2699 O OE2 . GLU A 1 529 ? 13.734  11.873  61.159  1.00 146.37 ? 510 GLU A OE2 1 
ATOM   2700 N N   . LEU A 1 530 ? 17.787  15.823  59.081  1.00 127.90 ? 511 LEU A N   1 
ATOM   2701 C CA  . LEU A 1 530 ? 18.307  17.134  59.524  1.00 119.94 ? 511 LEU A CA  1 
ATOM   2702 C C   . LEU A 1 530 ? 17.892  18.209  58.540  1.00 127.87 ? 511 LEU A C   1 
ATOM   2703 O O   . LEU A 1 530 ? 17.436  19.237  58.978  1.00 136.05 ? 511 LEU A O   1 
ATOM   2704 C CB  . LEU A 1 530 ? 19.821  17.043  59.639  1.00 116.56 ? 511 LEU A CB  1 
ATOM   2705 C CG  . LEU A 1 530 ? 20.309  16.235  60.829  1.00 123.60 ? 511 LEU A CG  1 
ATOM   2706 C CD1 . LEU A 1 530 ? 20.738  17.154  61.945  1.00 123.93 ? 511 LEU A CD1 1 
ATOM   2707 C CD2 . LEU A 1 530 ? 19.226  15.300  61.322  1.00 128.87 ? 511 LEU A CD2 1 
ATOM   2708 N N   . GLU A 1 531 ? 17.933  17.935  57.246  1.00 124.80 ? 512 GLU A N   1 
ATOM   2709 C CA  . GLU A 1 531 ? 17.500  18.956  56.265  1.00 129.11 ? 512 GLU A CA  1 
ATOM   2710 C C   . GLU A 1 531 ? 16.009  19.254  56.409  1.00 130.64 ? 512 GLU A C   1 
ATOM   2711 O O   . GLU A 1 531 ? 15.620  20.338  55.998  1.00 130.16 ? 512 GLU A O   1 
ATOM   2712 C CB  . GLU A 1 531 ? 17.859  18.580  54.833  1.00 130.04 ? 512 GLU A CB  1 
ATOM   2713 C CG  . GLU A 1 531 ? 18.033  19.793  53.941  1.00 134.13 ? 512 GLU A CG  1 
ATOM   2714 C CD  . GLU A 1 531 ? 19.468  20.120  53.571  1.00 140.01 ? 512 GLU A CD  1 
ATOM   2715 O OE1 . GLU A 1 531 ? 19.696  21.168  52.941  1.00 142.62 ? 512 GLU A OE1 1 
ATOM   2716 O OE2 . GLU A 1 531 ? 20.352  19.322  53.911  1.00 148.62 ? 512 GLU A OE2 1 
ATOM   2717 N N   . ALA A 1 532 ? 15.192  18.296  56.846  1.00 130.31 ? 513 ALA A N   1 
ATOM   2718 C CA  . ALA A 1 532 ? 13.750  18.567  56.995  1.00 133.63 ? 513 ALA A CA  1 
ATOM   2719 C C   . ALA A 1 532 ? 13.385  19.107  58.382  1.00 129.25 ? 513 ALA A C   1 
ATOM   2720 O O   . ALA A 1 532 ? 12.228  19.488  58.532  1.00 125.78 ? 513 ALA A O   1 
ATOM   2721 C CB  . ALA A 1 532 ? 12.975  17.321  56.680  1.00 133.10 ? 513 ALA A CB  1 
ATOM   2722 N N   . ASN A 1 533 ? 14.267  19.107  59.384  1.00 128.61 ? 514 ASN A N   1 
ATOM   2723 C CA  . ASN A 1 533 ? 13.765  19.635  60.669  1.00 126.11 ? 514 ASN A CA  1 
ATOM   2724 C C   . ASN A 1 533 ? 14.579  20.889  60.953  1.00 123.45 ? 514 ASN A C   1 
ATOM   2725 O O   . ASN A 1 533 ? 15.234  20.930  61.990  1.00 121.14 ? 514 ASN A O   1 
ATOM   2726 C CB  . ASN A 1 533 ? 13.975  18.624  61.789  1.00 131.57 ? 514 ASN A CB  1 
ATOM   2727 C CG  . ASN A 1 533 ? 13.002  17.471  61.702  1.00 141.71 ? 514 ASN A CG  1 
ATOM   2728 O OD1 . ASN A 1 533 ? 13.166  16.462  62.382  1.00 143.98 ? 514 ASN A OD1 1 
ATOM   2729 N ND2 . ASN A 1 533 ? 11.981  17.619  60.875  1.00 134.12 ? 514 ASN A ND2 1 
ATOM   2730 N N   . PRO A 1 534 ? 14.536  21.936  60.110  1.00 118.23 ? 515 PRO A N   1 
ATOM   2731 C CA  . PRO A 1 534 ? 15.375  23.071  60.302  1.00 113.58 ? 515 PRO A CA  1 
ATOM   2732 C C   . PRO A 1 534 ? 14.636  23.910  61.328  1.00 120.89 ? 515 PRO A C   1 
ATOM   2733 O O   . PRO A 1 534 ? 13.467  24.078  61.204  1.00 123.04 ? 515 PRO A O   1 
ATOM   2734 C CB  . PRO A 1 534 ? 15.282  23.793  58.965  1.00 108.16 ? 515 PRO A CB  1 
ATOM   2735 C CG  . PRO A 1 534 ? 13.863  23.609  58.577  1.00 103.88 ? 515 PRO A CG  1 
ATOM   2736 C CD  . PRO A 1 534 ? 13.499  22.260  59.145  1.00 115.54 ? 515 PRO A CD  1 
ATOM   2737 N N   . PRO A 1 535 ? 15.343  24.558  62.263  1.00 116.07 ? 516 PRO A N   1 
ATOM   2738 C CA  . PRO A 1 535 ? 14.738  25.401  63.267  1.00 116.48 ? 516 PRO A CA  1 
ATOM   2739 C C   . PRO A 1 535 ? 14.236  26.716  62.675  1.00 121.28 ? 516 PRO A C   1 
ATOM   2740 O O   . PRO A 1 535 ? 14.591  27.067  61.573  1.00 117.92 ? 516 PRO A O   1 
ATOM   2741 C CB  . PRO A 1 535 ? 15.895  25.678  64.220  1.00 119.35 ? 516 PRO A CB  1 
ATOM   2742 C CG  . PRO A 1 535 ? 16.807  24.536  63.973  1.00 116.57 ? 516 PRO A CG  1 
ATOM   2743 C CD  . PRO A 1 535 ? 16.765  24.443  62.471  1.00 118.81 ? 516 PRO A CD  1 
ATOM   2744 N N   . SER A 1 536 ? 13.505  27.465  63.494  1.00 125.33 ? 517 SER A N   1 
ATOM   2745 C CA  . SER A 1 536 ? 12.816  28.698  63.050  1.00 121.04 ? 517 SER A CA  1 
ATOM   2746 C C   . SER A 1 536 ? 13.779  29.638  62.341  1.00 115.19 ? 517 SER A C   1 
ATOM   2747 O O   . SER A 1 536 ? 14.893  29.852  62.800  1.00 109.79 ? 517 SER A O   1 
ATOM   2748 C CB  . SER A 1 536 ? 12.146  29.369  64.200  1.00 126.27 ? 517 SER A CB  1 
ATOM   2749 O OG  . SER A 1 536 ? 11.649  28.402  65.111  1.00 136.57 ? 517 SER A OG  1 
ATOM   2750 N N   . ASP A 1 537 ? 13.319  30.096  61.192  1.00 115.89 ? 518 ASP A N   1 
ATOM   2751 C CA  . ASP A 1 537 ? 14.089  30.956  60.278  1.00 117.80 ? 518 ASP A CA  1 
ATOM   2752 C C   . ASP A 1 537 ? 14.415  32.295  60.932  1.00 120.44 ? 518 ASP A C   1 
ATOM   2753 O O   . ASP A 1 537 ? 15.547  32.742  60.799  1.00 112.27 ? 518 ASP A O   1 
ATOM   2754 C CB  . ASP A 1 537 ? 13.252  31.142  59.023  1.00 117.52 ? 518 ASP A CB  1 
ATOM   2755 C CG  . ASP A 1 537 ? 13.973  31.968  58.000  1.00 128.10 ? 518 ASP A CG  1 
ATOM   2756 O OD1 . ASP A 1 537 ? 15.082  32.413  58.315  1.00 125.95 ? 518 ASP A OD1 1 
ATOM   2757 O OD2 . ASP A 1 537 ? 13.416  32.151  56.911  1.00 133.93 ? 518 ASP A OD2 1 
ATOM   2758 N N   . VAL A 1 538 ? 13.444  32.891  61.623  1.00 124.11 ? 519 VAL A N   1 
ATOM   2759 C CA  . VAL A 1 538 ? 13.619  34.222  62.263  1.00 110.63 ? 519 VAL A CA  1 
ATOM   2760 C C   . VAL A 1 538 ? 12.866  34.238  63.585  1.00 111.39 ? 519 VAL A C   1 
ATOM   2761 O O   . VAL A 1 538 ? 11.934  33.456  63.721  1.00 111.81 ? 519 VAL A O   1 
ATOM   2762 C CB  . VAL A 1 538 ? 12.994  35.290  61.363  1.00 106.92 ? 519 VAL A CB  1 
ATOM   2763 C CG1 . VAL A 1 538 ? 13.840  35.548  60.135  1.00 116.53 ? 519 VAL A CG1 1 
ATOM   2764 C CG2 . VAL A 1 538 ? 11.588  34.887  60.972  1.00 97.12  ? 519 VAL A CG2 1 
ATOM   2765 N N   . TYR A 1 539 ? 13.304  35.066  64.532  1.00 113.90 ? 520 TYR A N   1 
ATOM   2766 C CA  . TYR A 1 539 ? 12.543  35.200  65.793  1.00 107.40 ? 520 TYR A CA  1 
ATOM   2767 C C   . TYR A 1 539 ? 11.222  35.890  65.493  1.00 102.89 ? 520 TYR A C   1 
ATOM   2768 O O   . TYR A 1 539 ? 10.193  35.407  65.914  1.00 101.50 ? 520 TYR A O   1 
ATOM   2769 C CB  . TYR A 1 539 ? 13.245  36.125  66.778  1.00 104.63 ? 520 TYR A CB  1 
ATOM   2770 C CG  . TYR A 1 539 ? 12.423  36.341  68.014  1.00 103.33 ? 520 TYR A CG  1 
ATOM   2771 C CD1 . TYR A 1 539 ? 11.916  35.265  68.698  1.00 107.49 ? 520 TYR A CD1 1 
ATOM   2772 C CD2 . TYR A 1 539 ? 12.115  37.599  68.477  1.00 106.58 ? 520 TYR A CD2 1 
ATOM   2773 C CE1 . TYR A 1 539 ? 11.145  35.430  69.830  1.00 108.51 ? 520 TYR A CE1 1 
ATOM   2774 C CE2 . TYR A 1 539 ? 11.341  37.782  69.606  1.00 102.80 ? 520 TYR A CE2 1 
ATOM   2775 C CZ  . TYR A 1 539 ? 10.849  36.692  70.284  1.00 104.07 ? 520 TYR A CZ  1 
ATOM   2776 O OH  . TYR A 1 539 ? 10.069  36.833  71.386  1.00 97.75  ? 520 TYR A OH  1 
ATOM   2777 N N   . LEU A 1 540 ? 11.278  36.975  64.732  1.00 102.02 ? 521 LEU A N   1 
ATOM   2778 C CA  . LEU A 1 540 ? 10.037  37.705  64.405  1.00 101.81 ? 521 LEU A CA  1 
ATOM   2779 C C   . LEU A 1 540 ? 10.173  38.390  63.054  1.00 104.27 ? 521 LEU A C   1 
ATOM   2780 O O   . LEU A 1 540 ? 11.188  39.019  62.831  1.00 107.23 ? 521 LEU A O   1 
ATOM   2781 C CB  . LEU A 1 540 ? 9.836   38.741  65.498  1.00 108.20 ? 521 LEU A CB  1 
ATOM   2782 C CG  . LEU A 1 540 ? 8.945   38.279  66.638  1.00 108.49 ? 521 LEU A CG  1 
ATOM   2783 C CD1 . LEU A 1 540 ? 8.942   39.297  67.744  1.00 106.98 ? 521 LEU A CD1 1 
ATOM   2784 C CD2 . LEU A 1 540 ? 7.538   38.065  66.138  1.00 108.03 ? 521 LEU A CD2 1 
ATOM   2785 N N   . SER A 1 541 ? 9.116   38.362  62.257  1.00 102.70 ? 522 SER A N   1 
ATOM   2786 C CA  . SER A 1 541 ? 9.148   38.971  60.910  1.00 107.66 ? 522 SER A CA  1 
ATOM   2787 C C   . SER A 1 541 ? 8.901   40.462  61.021  1.00 105.51 ? 522 SER A C   1 
ATOM   2788 O O   . SER A 1 541 ? 8.324   40.857  62.008  1.00 109.66 ? 522 SER A O   1 
ATOM   2789 C CB  . SER A 1 541 ? 8.059   38.391  60.098  1.00 113.26 ? 522 SER A CB  1 
ATOM   2790 O OG  . SER A 1 541 ? 6.823   38.926  60.526  1.00 103.72 ? 522 SER A OG  1 
ATOM   2791 N N   . SER A 1 542 ? 9.265   41.221  59.994  1.00 109.47 ? 523 SER A N   1 
ATOM   2792 C CA  . SER A 1 542 ? 8.982   42.672  59.985  1.00 111.45 ? 523 SER A CA  1 
ATOM   2793 C C   . SER A 1 542 ? 7.487   42.866  60.212  1.00 108.73 ? 523 SER A C   1 
ATOM   2794 O O   . SER A 1 542 ? 7.119   43.718  60.988  1.00 111.82 ? 523 SER A O   1 
ATOM   2795 C CB  . SER A 1 542 ? 9.386   43.256  58.686  1.00 115.41 ? 523 SER A CB  1 
ATOM   2796 O OG  . SER A 1 542 ? 8.365   43.040  57.734  1.00 127.71 ? 523 SER A OG  1 
ATOM   2797 N N   . ARG A 1 543 ? 6.662   42.112  59.504  1.00 110.12 ? 524 ARG A N   1 
ATOM   2798 C CA  . ARG A 1 543 ? 5.210   42.198  59.739  1.00 111.76 ? 524 ARG A CA  1 
ATOM   2799 C C   . ARG A 1 543 ? 4.975   41.879  61.205  1.00 111.50 ? 524 ARG A C   1 
ATOM   2800 O O   . ARG A 1 543 ? 4.356   42.683  61.868  1.00 110.71 ? 524 ARG A O   1 
ATOM   2801 C CB  . ARG A 1 543 ? 4.508   41.101  58.945  1.00 117.30 ? 524 ARG A CB  1 
ATOM   2802 C CG  . ARG A 1 543 ? 3.225   41.544  58.262  1.00 113.38 ? 524 ARG A CG  1 
ATOM   2803 C CD  . ARG A 1 543 ? 2.199   40.443  58.291  1.00 114.97 ? 524 ARG A CD  1 
ATOM   2804 N NE  . ARG A 1 543 ? 1.087   40.818  57.449  1.00 125.97 ? 524 ARG A NE  1 
ATOM   2805 C CZ  . ARG A 1 543 ? 0.027   40.057  57.258  1.00 130.87 ? 524 ARG A CZ  1 
ATOM   2806 N NH1 . ARG A 1 543 ? -0.052  38.886  57.859  1.00 126.30 ? 524 ARG A NH1 1 
ATOM   2807 N NH2 . ARG A 1 543 ? -0.951  40.466  56.473  1.00 128.43 ? 524 ARG A NH2 1 
ATOM   2808 N N   . ASP A 1 544 ? 5.490   40.745  61.666  1.00 108.43 ? 525 ASP A N   1 
ATOM   2809 C CA  . ASP A 1 544 ? 5.287   40.301  63.066  1.00 109.07 ? 525 ASP A CA  1 
ATOM   2810 C C   . ASP A 1 544 ? 5.674   41.419  64.027  1.00 107.96 ? 525 ASP A C   1 
ATOM   2811 O O   . ASP A 1 544 ? 4.816   41.881  64.754  1.00 106.15 ? 525 ASP A O   1 
ATOM   2812 C CB  . ASP A 1 544 ? 6.135   39.076  63.394  1.00 117.38 ? 525 ASP A CB  1 
ATOM   2813 C CG  . ASP A 1 544 ? 5.694   37.794  62.718  1.00 124.94 ? 525 ASP A CG  1 
ATOM   2814 O OD1 . ASP A 1 544 ? 4.478   37.619  62.521  1.00 125.74 ? 525 ASP A OD1 1 
ATOM   2815 O OD2 . ASP A 1 544 ? 6.579   36.977  62.405  1.00 119.19 ? 525 ASP A OD2 1 
ATOM   2816 N N   . ARG A 1 545 ? 6.888   41.951  63.917  1.00 109.01 ? 526 ARG A N   1 
ATOM   2817 C CA  . ARG A 1 545 ? 7.365   42.997  64.861  1.00 103.53 ? 526 ARG A CA  1 
ATOM   2818 C C   . ARG A 1 545 ? 6.631   44.324  64.700  1.00 100.40 ? 526 ARG A C   1 
ATOM   2819 O O   . ARG A 1 545 ? 6.768   45.135  65.584  1.00 104.12 ? 526 ARG A O   1 
ATOM   2820 C CB  . ARG A 1 545 ? 8.868   43.234  64.762  1.00 101.91 ? 526 ARG A CB  1 
ATOM   2821 C CG  . ARG A 1 545 ? 9.349   44.344  65.682  1.00 107.43 ? 526 ARG A CG  1 
ATOM   2822 C CD  . ARG A 1 545 ? 10.746  44.090  66.203  1.00 109.95 ? 526 ARG A CD  1 
ATOM   2823 N NE  . ARG A 1 545 ? 11.184  44.853  67.367  1.00 115.40 ? 526 ARG A NE  1 
ATOM   2824 C CZ  . ARG A 1 545 ? 10.688  46.006  67.801  1.00 118.94 ? 526 ARG A CZ  1 
ATOM   2825 N NH1 . ARG A 1 545 ? 9.686   46.593  67.178  1.00 109.44 ? 526 ARG A NH1 1 
ATOM   2826 N NH2 . ARG A 1 545 ? 11.207  46.575  68.871  1.00 123.24 ? 526 ARG A NH2 1 
ATOM   2827 N N   . GLN A 1 546 ? 5.956   44.572  63.586  1.00 97.97  ? 527 GLN A N   1 
ATOM   2828 C CA  . GLN A 1 546 ? 5.146   45.798  63.474  1.00 100.60 ? 527 GLN A CA  1 
ATOM   2829 C C   . GLN A 1 546 ? 3.940   45.569  64.366  1.00 97.83  ? 527 GLN A C   1 
ATOM   2830 O O   . GLN A 1 546 ? 3.542   46.474  65.059  1.00 101.86 ? 527 GLN A O   1 
ATOM   2831 C CB  . GLN A 1 546 ? 4.616   45.940  62.057  1.00 102.30 ? 527 GLN A CB  1 
ATOM   2832 C CG  . GLN A 1 546 ? 5.439   46.853  61.174  1.00 109.23 ? 527 GLN A CG  1 
ATOM   2833 C CD  . GLN A 1 546 ? 5.056   46.618  59.738  1.00 113.75 ? 527 GLN A CD  1 
ATOM   2834 O OE1 . GLN A 1 546 ? 5.081   47.516  58.909  1.00 105.64 ? 527 GLN A OE1 1 
ATOM   2835 N NE2 . GLN A 1 546 ? 4.681   45.390  59.441  1.00 118.58 ? 527 GLN A NE2 1 
ATOM   2836 N N   . ILE A 1 547 ? 3.414   44.355  64.362  1.00 93.53  ? 528 ILE A N   1 
ATOM   2837 C CA  . ILE A 1 547 ? 2.233   44.045  65.202  1.00 94.20  ? 528 ILE A CA  1 
ATOM   2838 C C   . ILE A 1 547 ? 2.680   44.029  66.647  1.00 94.84  ? 528 ILE A C   1 
ATOM   2839 O O   . ILE A 1 547 ? 1.947   44.488  67.483  1.00 95.67  ? 528 ILE A O   1 
ATOM   2840 C CB  . ILE A 1 547 ? 1.660   42.683  64.833  1.00 95.81  ? 528 ILE A CB  1 
ATOM   2841 C CG1 . ILE A 1 547 ? 1.033   42.709  63.447  1.00 101.91 ? 528 ILE A CG1 1 
ATOM   2842 C CG2 . ILE A 1 547 ? 0.663   42.256  65.880  1.00 90.63  ? 528 ILE A CG2 1 
ATOM   2843 C CD1 . ILE A 1 547 ? 0.024   41.628  63.252  1.00 103.36 ? 528 ILE A CD1 1 
ATOM   2844 N N   . LEU A 1 548 ? 3.895   43.572  66.910  1.00 90.71  ? 529 LEU A N   1 
ATOM   2845 C CA  . LEU A 1 548 ? 4.411   43.564  68.292  1.00 88.35  ? 529 LEU A CA  1 
ATOM   2846 C C   . LEU A 1 548 ? 4.400   44.990  68.816  1.00 95.13  ? 529 LEU A C   1 
ATOM   2847 O O   . LEU A 1 548 ? 3.958   45.182  69.917  1.00 91.78  ? 529 LEU A O   1 
ATOM   2848 C CB  . LEU A 1 548 ? 5.842   43.047  68.278  1.00 86.79  ? 529 LEU A CB  1 
ATOM   2849 C CG  . LEU A 1 548 ? 6.467   42.982  69.656  1.00 83.50  ? 529 LEU A CG  1 
ATOM   2850 C CD1 . LEU A 1 548 ? 5.440   42.498  70.640  1.00 84.34  ? 529 LEU A CD1 1 
ATOM   2851 C CD2 . LEU A 1 548 ? 7.657   42.060  69.658  1.00 75.62  ? 529 LEU A CD2 1 
ATOM   2852 N N   . ASP A 1 549 ? 4.840   45.955  68.015  1.00 92.66  ? 530 ASP A N   1 
ATOM   2853 C CA  . ASP A 1 549 ? 4.832   47.384  68.391  1.00 86.93  ? 530 ASP A CA  1 
ATOM   2854 C C   . ASP A 1 549 ? 3.462   47.786  68.932  1.00 87.69  ? 530 ASP A C   1 
ATOM   2855 O O   . ASP A 1 549 ? 3.421   48.428  69.951  1.00 90.85  ? 530 ASP A O   1 
ATOM   2856 C CB  . ASP A 1 549 ? 5.263   48.234  67.208  1.00 90.98  ? 530 ASP A CB  1 
ATOM   2857 C CG  . ASP A 1 549 ? 6.767   48.335  67.119  1.00 97.85  ? 530 ASP A CG  1 
ATOM   2858 O OD1 . ASP A 1 549 ? 7.426   47.725  67.941  1.00 91.58  ? 530 ASP A OD1 1 
ATOM   2859 O OD2 . ASP A 1 549 ? 7.252   49.028  66.234  1.00 104.52 ? 530 ASP A OD2 1 
ATOM   2860 N N   . TRP A 1 550 ? 2.412   47.416  68.232  1.00 86.21  ? 531 TRP A N   1 
ATOM   2861 C CA  . TRP A 1 550 ? 1.073   47.829  68.689  1.00 83.60  ? 531 TRP A CA  1 
ATOM   2862 C C   . TRP A 1 550 ? 0.835   47.289  70.081  1.00 82.07  ? 531 TRP A C   1 
ATOM   2863 O O   . TRP A 1 550 ? 0.031   47.830  70.777  1.00 86.28  ? 531 TRP A O   1 
ATOM   2864 C CB  . TRP A 1 550 ? 0.021   47.333  67.723  1.00 80.64  ? 531 TRP A CB  1 
ATOM   2865 C CG  . TRP A 1 550 ? -1.351  47.730  68.128  1.00 79.16  ? 531 TRP A CG  1 
ATOM   2866 C CD1 . TRP A 1 550 ? -2.115  48.699  67.570  1.00 78.06  ? 531 TRP A CD1 1 
ATOM   2867 C CD2 . TRP A 1 550 ? -2.133  47.144  69.167  1.00 79.64  ? 531 TRP A CD2 1 
ATOM   2868 N NE1 . TRP A 1 550 ? -3.325  48.752  68.189  1.00 80.01  ? 531 TRP A NE1 1 
ATOM   2869 C CE2 . TRP A 1 550 ? -3.365  47.809  69.169  1.00 81.70  ? 531 TRP A CE2 1 
ATOM   2870 C CE3 . TRP A 1 550 ? -1.922  46.115  70.077  1.00 83.06  ? 531 TRP A CE3 1 
ATOM   2871 C CZ2 . TRP A 1 550 ? -4.373  47.500  70.063  1.00 82.86  ? 531 TRP A CZ2 1 
ATOM   2872 C CZ3 . TRP A 1 550 ? -2.921  45.808  70.961  1.00 88.09  ? 531 TRP A CZ3 1 
ATOM   2873 C CH2 . TRP A 1 550 ? -4.129  46.488  70.950  1.00 88.04  ? 531 TRP A CH2 1 
ATOM   2874 N N   . HIS A 1 551 ? 1.560   46.265  70.474  1.00 80.93  ? 532 HIS A N   1 
ATOM   2875 C CA  . HIS A 1 551 ? 1.325   45.790  71.849  1.00 86.66  ? 532 HIS A CA  1 
ATOM   2876 C C   . HIS A 1 551 ? 2.148   46.670  72.773  1.00 87.98  ? 532 HIS A C   1 
ATOM   2877 O O   . HIS A 1 551 ? 1.778   46.829  73.908  1.00 88.65  ? 532 HIS A O   1 
ATOM   2878 C CB  . HIS A 1 551 ? 1.645   44.309  71.966  1.00 90.93  ? 532 HIS A CB  1 
ATOM   2879 C CG  . HIS A 1 551 ? 0.509   43.435  71.581  1.00 91.57  ? 532 HIS A CG  1 
ATOM   2880 N ND1 . HIS A 1 551 ? -0.342  42.908  72.495  1.00 96.67  ? 532 HIS A ND1 1 
ATOM   2881 C CD2 . HIS A 1 551 ? 0.089   42.993  70.389  1.00 99.10  ? 532 HIS A CD2 1 
ATOM   2882 C CE1 . HIS A 1 551 ? -1.238  42.168  71.891  1.00 97.57  ? 532 HIS A CE1 1 
ATOM   2883 N NE2 . HIS A 1 551 ? -0.998  42.210  70.605  1.00 103.96 ? 532 HIS A NE2 1 
ATOM   2884 N N   . PHE A 1 552 ? 3.230   47.230  72.268  1.00 83.39  ? 533 PHE A N   1 
ATOM   2885 C CA  . PHE A 1 552 ? 4.039   48.134  73.101  1.00 81.32  ? 533 PHE A CA  1 
ATOM   2886 C C   . PHE A 1 552 ? 3.336   49.474  73.144  1.00 81.07  ? 533 PHE A C   1 
ATOM   2887 O O   . PHE A 1 552 ? 3.416   50.158  74.120  1.00 84.13  ? 533 PHE A O   1 
ATOM   2888 C CB  . PHE A 1 552 ? 5.410   48.293  72.474  1.00 82.84  ? 533 PHE A CB  1 
ATOM   2889 C CG  . PHE A 1 552 ? 6.251   47.061  72.607  1.00 87.49  ? 533 PHE A CG  1 
ATOM   2890 C CD1 . PHE A 1 552 ? 6.152   46.274  73.727  1.00 87.29  ? 533 PHE A CD1 1 
ATOM   2891 C CD2 . PHE A 1 552 ? 7.137   46.700  71.625  1.00 87.35  ? 533 PHE A CD2 1 
ATOM   2892 C CE1 . PHE A 1 552 ? 6.939   45.151  73.864  1.00 83.25  ? 533 PHE A CE1 1 
ATOM   2893 C CE2 . PHE A 1 552 ? 7.919   45.576  71.765  1.00 84.33  ? 533 PHE A CE2 1 
ATOM   2894 C CZ  . PHE A 1 552 ? 7.820   44.807  72.883  1.00 78.37  ? 533 PHE A CZ  1 
ATOM   2895 N N   . ALA A 1 553 ? 2.601   49.811  72.101  1.00 83.90  ? 534 ALA A N   1 
ATOM   2896 C CA  . ALA A 1 553 ? 1.864   51.084  72.145  1.00 81.63  ? 534 ALA A CA  1 
ATOM   2897 C C   . ALA A 1 553 ? 0.842   50.998  73.264  1.00 82.99  ? 534 ALA A C   1 
ATOM   2898 O O   . ALA A 1 553 ? 0.698   51.968  73.969  1.00 87.13  ? 534 ALA A O   1 
ATOM   2899 C CB  . ALA A 1 553 ? 1.195   51.343  70.839  1.00 79.32  ? 534 ALA A CB  1 
ATOM   2900 N N   . ASN A 1 554 ? 0.150   49.874  73.388  1.00 81.10  ? 535 ASN A N   1 
ATOM   2901 C CA  . ASN A 1 554 ? -0.816  49.701  74.491  1.00 82.63  ? 535 ASN A CA  1 
ATOM   2902 C C   . ASN A 1 554 ? -0.101  49.983  75.804  1.00 80.76  ? 535 ASN A C   1 
ATOM   2903 O O   . ASN A 1 554 ? -0.555  50.843  76.512  1.00 80.50  ? 535 ASN A O   1 
ATOM   2904 C CB  . ASN A 1 554 ? -1.453  48.322  74.478  1.00 82.50  ? 535 ASN A CB  1 
ATOM   2905 C CG  . ASN A 1 554 ? -2.941  48.426  74.676  1.00 89.32  ? 535 ASN A CG  1 
ATOM   2906 O OD1 . ASN A 1 554 ? -3.552  49.358  74.196  1.00 88.65  ? 535 ASN A OD1 1 
ATOM   2907 N ND2 . ASN A 1 554 ? -3.524  47.506  75.411  1.00 95.61  ? 535 ASN A ND2 1 
ATOM   2908 N N   . LEU A 1 555 ? 1.039   49.353  76.049  1.00 80.44  ? 536 LEU A N   1 
ATOM   2909 C CA  . LEU A 1 555 ? 1.830   49.603  77.275  1.00 75.15  ? 536 LEU A CA  1 
ATOM   2910 C C   . LEU A 1 555 ? 2.126   51.088  77.383  1.00 80.42  ? 536 LEU A C   1 
ATOM   2911 O O   . LEU A 1 555 ? 1.898   51.653  78.417  1.00 82.41  ? 536 LEU A O   1 
ATOM   2912 C CB  . LEU A 1 555 ? 3.154   48.873  77.136  1.00 67.45  ? 536 LEU A CB  1 
ATOM   2913 C CG  . LEU A 1 555 ? 3.336   47.743  78.121  1.00 76.37  ? 536 LEU A CG  1 
ATOM   2914 C CD1 . LEU A 1 555 ? 4.719   47.778  78.701  1.00 73.40  ? 536 LEU A CD1 1 
ATOM   2915 C CD2 . LEU A 1 555 ? 2.308   47.872  79.208  1.00 81.73  ? 536 LEU A CD2 1 
ATOM   2916 N N   . GLU A 1 556 ? 2.573   51.704  76.304  1.00 74.72  ? 537 GLU A N   1 
ATOM   2917 C CA  . GLU A 1 556 ? 2.883   53.145  76.326  1.00 75.34  ? 537 GLU A CA  1 
ATOM   2918 C C   . GLU A 1 556 ? 1.625   53.937  76.646  1.00 78.29  ? 537 GLU A C   1 
ATOM   2919 O O   . GLU A 1 556 ? 1.708   54.885  77.389  1.00 80.81  ? 537 GLU A O   1 
ATOM   2920 C CB  . GLU A 1 556 ? 3.531   53.531  75.007  1.00 77.51  ? 537 GLU A CB  1 
ATOM   2921 C CG  . GLU A 1 556 ? 4.899   52.916  74.863  1.00 77.59  ? 537 GLU A CG  1 
ATOM   2922 C CD  . GLU A 1 556 ? 5.718   53.480  73.736  1.00 83.11  ? 537 GLU A CD  1 
ATOM   2923 O OE1 . GLU A 1 556 ? 5.149   54.128  72.897  1.00 90.64  ? 537 GLU A OE1 1 
ATOM   2924 O OE2 . GLU A 1 556 ? 6.910   53.272  73.726  1.00 83.66  ? 537 GLU A OE2 1 
ATOM   2925 N N   . PHE A 1 557 ? 0.481   53.542  76.126  1.00 78.67  ? 538 PHE A N   1 
ATOM   2926 C CA  . PHE A 1 557 ? -0.742  54.295  76.459  1.00 76.91  ? 538 PHE A CA  1 
ATOM   2927 C C   . PHE A 1 557 ? -1.170  54.034  77.894  1.00 74.86  ? 538 PHE A C   1 
ATOM   2928 O O   . PHE A 1 557 ? -1.856  54.844  78.426  1.00 81.78  ? 538 PHE A O   1 
ATOM   2929 C CB  . PHE A 1 557 ? -1.873  53.865  75.544  1.00 84.02  ? 538 PHE A CB  1 
ATOM   2930 C CG  . PHE A 1 557 ? -3.164  53.584  76.251  1.00 85.71  ? 538 PHE A CG  1 
ATOM   2931 C CD1 . PHE A 1 557 ? -3.962  54.613  76.685  1.00 84.11  ? 538 PHE A CD1 1 
ATOM   2932 C CD2 . PHE A 1 557 ? -3.575  52.292  76.472  1.00 91.66  ? 538 PHE A CD2 1 
ATOM   2933 C CE1 . PHE A 1 557 ? -5.152  54.352  77.327  1.00 93.89  ? 538 PHE A CE1 1 
ATOM   2934 C CE2 . PHE A 1 557 ? -4.769  52.033  77.113  1.00 97.23  ? 538 PHE A CE2 1 
ATOM   2935 C CZ  . PHE A 1 557 ? -5.552  53.066  77.541  1.00 97.76  ? 538 PHE A CZ  1 
ATOM   2936 N N   . ALA A 1 558 ? -0.825  52.906  78.478  1.00 80.60  ? 539 ALA A N   1 
ATOM   2937 C CA  . ALA A 1 558 ? -1.276  52.677  79.858  1.00 83.35  ? 539 ALA A CA  1 
ATOM   2938 C C   . ALA A 1 558 ? -0.425  53.500  80.798  1.00 81.28  ? 539 ALA A C   1 
ATOM   2939 O O   . ALA A 1 558 ? -0.918  53.925  81.802  1.00 82.21  ? 539 ALA A O   1 
ATOM   2940 C CB  . ALA A 1 558 ? -1.123  51.231  80.189  1.00 86.20  ? 539 ALA A CB  1 
ATOM   2941 N N   . ASN A 1 559 ? 0.840   53.654  80.473  1.00 72.52  ? 540 ASN A N   1 
ATOM   2942 C CA  . ASN A 1 559 ? 1.730   54.390  81.323  1.00 68.45  ? 540 ASN A CA  1 
ATOM   2943 C C   . ASN A 1 559 ? 1.896   55.812  80.854  1.00 71.62  ? 540 ASN A C   1 
ATOM   2944 O O   . ASN A 1 559 ? 2.687   56.551  81.444  1.00 73.22  ? 540 ASN A O   1 
ATOM   2945 C CB  . ASN A 1 559 ? 3.062   53.667  81.368  1.00 66.94  ? 540 ASN A CB  1 
ATOM   2946 C CG  . ASN A 1 559 ? 2.942   52.327  82.029  1.00 73.98  ? 540 ASN A CG  1 
ATOM   2947 O OD1 . ASN A 1 559 ? 2.708   52.222  83.222  1.00 77.02  ? 540 ASN A OD1 1 
ATOM   2948 N ND2 . ASN A 1 559 ? 2.956   51.289  81.217  1.00 80.27  ? 540 ASN A ND2 1 
ATOM   2949 N N   . ALA A 1 560 ? 1.141   56.212  79.835  1.00 72.98  ? 541 ALA A N   1 
ATOM   2950 C CA  . ALA A 1 560 ? 1.286   57.520  79.175  1.00 77.33  ? 541 ALA A CA  1 
ATOM   2951 C C   . ALA A 1 560 ? 2.750   57.953  79.068  1.00 69.40  ? 541 ALA A C   1 
ATOM   2952 O O   . ALA A 1 560 ? 3.122   59.050  79.474  1.00 69.06  ? 541 ALA A O   1 
ATOM   2953 C CB  . ALA A 1 560 ? 0.461   58.595  79.889  1.00 72.64  ? 541 ALA A CB  1 
ATOM   2954 N N   . THR A 1 561 ? 3.591   57.076  78.519  1.00 65.12  ? 542 THR A N   1 
ATOM   2955 C CA  . THR A 1 561 ? 4.983   57.441  78.294  1.00 65.01  ? 542 THR A CA  1 
ATOM   2956 C C   . THR A 1 561 ? 5.715   56.407  77.437  1.00 70.62  ? 542 THR A C   1 
ATOM   2957 O O   . THR A 1 561 ? 5.340   55.228  77.406  1.00 66.75  ? 542 THR A O   1 
ATOM   2958 C CB  . THR A 1 561 ? 5.714   57.642  79.624  1.00 62.66  ? 542 THR A CB  1 
ATOM   2959 O OG1 . THR A 1 561 ? 7.070   58.032  79.383  1.00 65.04  ? 542 THR A OG1 1 
ATOM   2960 C CG2 . THR A 1 561 ? 5.697   56.383  80.440  1.00 67.26  ? 542 THR A CG2 1 
ATOM   2961 N N   . PRO A 1 562 ? 6.710   56.841  76.668  1.00 70.31  ? 543 PRO A N   1 
ATOM   2962 C CA  . PRO A 1 562 ? 7.637   55.903  76.032  1.00 70.97  ? 543 PRO A CA  1 
ATOM   2963 C C   . PRO A 1 562 ? 8.247   54.922  77.012  1.00 71.40  ? 543 PRO A C   1 
ATOM   2964 O O   . PRO A 1 562 ? 8.766   55.307  78.058  1.00 74.09  ? 543 PRO A O   1 
ATOM   2965 C CB  . PRO A 1 562 ? 8.709   56.827  75.452  1.00 74.59  ? 543 PRO A CB  1 
ATOM   2966 C CG  . PRO A 1 562 ? 8.106   58.217  75.472  1.00 74.33  ? 543 PRO A CG  1 
ATOM   2967 C CD  . PRO A 1 562 ? 6.729   58.147  75.995  1.00 71.41  ? 543 PRO A CD  1 
ATOM   2968 N N   . LEU A 1 563 ? 8.260   53.646  76.628  1.00 70.19  ? 544 LEU A N   1 
ATOM   2969 C CA  . LEU A 1 563 ? 8.785   52.608  77.508  1.00 67.98  ? 544 LEU A CA  1 
ATOM   2970 C C   . LEU A 1 563 ? 10.252  52.830  77.883  1.00 69.07  ? 544 LEU A C   1 
ATOM   2971 O O   . LEU A 1 563 ? 10.775  52.112  78.741  1.00 75.48  ? 544 LEU A O   1 
ATOM   2972 C CB  . LEU A 1 563 ? 8.588   51.254  76.835  1.00 69.23  ? 544 LEU A CB  1 
ATOM   2973 C CG  . LEU A 1 563 ? 7.168   50.945  76.347  1.00 72.18  ? 544 LEU A CG  1 
ATOM   2974 C CD1 . LEU A 1 563 ? 7.047   49.474  76.060  1.00 81.21  ? 544 LEU A CD1 1 
ATOM   2975 C CD2 . LEU A 1 563 ? 6.121   51.281  77.352  1.00 77.76  ? 544 LEU A CD2 1 
ATOM   2976 N N   . SER A 1 564 ? 10.926  53.797  77.277  1.00 64.79  ? 545 SER A N   1 
ATOM   2977 C CA  . SER A 1 564 ? 12.311  54.066  77.621  1.00 66.89  ? 545 SER A CA  1 
ATOM   2978 C C   . SER A 1 564 ? 12.429  54.914  78.859  1.00 75.19  ? 545 SER A C   1 
ATOM   2979 O O   . SER A 1 564 ? 13.544  55.113  79.356  1.00 80.16  ? 545 SER A O   1 
ATOM   2980 C CB  . SER A 1 564 ? 13.000  54.785  76.475  1.00 74.05  ? 545 SER A CB  1 
ATOM   2981 O OG  . SER A 1 564 ? 12.159  55.826  76.012  1.00 80.20  ? 545 SER A OG  1 
ATOM   2982 N N   . THR A 1 565 ? 11.306  55.449  79.325  1.00 75.63  ? 546 THR A N   1 
ATOM   2983 C CA  . THR A 1 565 ? 11.266  56.282  80.510  1.00 74.73  ? 546 THR A CA  1 
ATOM   2984 C C   . THR A 1 565 ? 10.754  55.543  81.735  1.00 75.75  ? 546 THR A C   1 
ATOM   2985 O O   . THR A 1 565 ? 11.052  55.975  82.856  1.00 77.82  ? 546 THR A O   1 
ATOM   2986 C CB  . THR A 1 565 ? 10.387  57.520  80.273  1.00 73.44  ? 546 THR A CB  1 
ATOM   2987 O OG1 . THR A 1 565 ? 9.019   57.118  80.118  1.00 67.71  ? 546 THR A OG1 1 
ATOM   2988 C CG2 . THR A 1 565 ? 10.852  58.309  79.048  1.00 67.69  ? 546 THR A CG2 1 
ATOM   2989 N N   . LEU A 1 566 ? 10.003  54.447  81.553  1.00 72.70  ? 547 LEU A N   1 
ATOM   2990 C CA  . LEU A 1 566 ? 9.507   53.673  82.691  1.00 71.38  ? 547 LEU A CA  1 
ATOM   2991 C C   . LEU A 1 566 ? 10.654  53.019  83.446  1.00 68.27  ? 547 LEU A C   1 
ATOM   2992 O O   . LEU A 1 566 ? 11.616  52.544  82.853  1.00 74.80  ? 547 LEU A O   1 
ATOM   2993 C CB  . LEU A 1 566 ? 8.525   52.604  82.221  1.00 67.60  ? 547 LEU A CB  1 
ATOM   2994 C CG  . LEU A 1 566 ? 7.178   53.161  81.755  1.00 69.28  ? 547 LEU A CG  1 
ATOM   2995 C CD1 . LEU A 1 566 ? 6.280   52.067  81.289  1.00 70.00  ? 547 LEU A CD1 1 
ATOM   2996 C CD2 . LEU A 1 566 ? 6.510   53.866  82.895  1.00 72.53  ? 547 LEU A CD2 1 
ATOM   2997 N N   . SER A 1 567 ? 10.565  53.013  84.763  1.00 65.00  ? 548 SER A N   1 
ATOM   2998 C CA  . SER A 1 567 ? 11.496  52.214  85.547  1.00 70.03  ? 548 SER A CA  1 
ATOM   2999 C C   . SER A 1 567 ? 11.258  50.738  85.289  1.00 73.84  ? 548 SER A C   1 
ATOM   3000 O O   . SER A 1 567 ? 10.124  50.265  85.394  1.00 74.95  ? 548 SER A O   1 
ATOM   3001 C CB  . SER A 1 567 ? 11.318  52.504  87.031  1.00 70.48  ? 548 SER A CB  1 
ATOM   3002 O OG  . SER A 1 567 ? 11.996  51.555  87.809  1.00 66.61  ? 548 SER A OG  1 
ATOM   3003 N N   . LEU A 1 568 ? 12.315  49.996  84.959  1.00 73.70  ? 549 LEU A N   1 
ATOM   3004 C CA  . LEU A 1 568 ? 12.146  48.551  84.882  1.00 76.34  ? 549 LEU A CA  1 
ATOM   3005 C C   . LEU A 1 568 ? 11.640  48.015  86.215  1.00 73.02  ? 549 LEU A C   1 
ATOM   3006 O O   . LEU A 1 568 ? 10.546  47.450  86.299  1.00 70.44  ? 549 LEU A O   1 
ATOM   3007 C CB  . LEU A 1 568 ? 13.458  47.856  84.539  1.00 81.78  ? 549 LEU A CB  1 
ATOM   3008 C CG  . LEU A 1 568 ? 13.383  46.470  83.893  1.00 73.42  ? 549 LEU A CG  1 
ATOM   3009 C CD1 . LEU A 1 568 ? 14.778  46.037  83.622  1.00 78.01  ? 549 LEU A CD1 1 
ATOM   3010 C CD2 . LEU A 1 568 ? 12.675  45.470  84.721  1.00 79.48  ? 549 LEU A CD2 1 
ATOM   3011 N N   . LYS A 1 569 ? 12.435  48.197  87.275  1.00 71.58  ? 550 LYS A N   1 
ATOM   3012 C CA  . LYS A 1 569 ? 12.114  47.594  88.565  1.00 75.01  ? 550 LYS A CA  1 
ATOM   3013 C C   . LYS A 1 569 ? 10.700  47.935  89.033  1.00 75.27  ? 550 LYS A C   1 
ATOM   3014 O O   . LYS A 1 569 ? 9.984   47.051  89.516  1.00 77.83  ? 550 LYS A O   1 
ATOM   3015 C CB  . LYS A 1 569 ? 13.150  47.992  89.622  1.00 72.15  ? 550 LYS A CB  1 
ATOM   3016 C CG  . LYS A 1 569 ? 12.938  47.222  90.945  1.00 82.99  ? 550 LYS A CG  1 
ATOM   3017 C CD  . LYS A 1 569 ? 14.199  46.537  91.512  1.00 89.44  ? 550 LYS A CD  1 
ATOM   3018 C CE  . LYS A 1 569 ? 15.282  47.533  91.930  1.00 95.04  ? 550 LYS A CE  1 
ATOM   3019 N NZ  . LYS A 1 569 ? 16.428  46.879  92.664  1.00 111.09 ? 550 LYS A NZ  1 
ATOM   3020 N N   . HIS A 1 570 ? 10.256  49.191  88.860  1.00 76.34  ? 551 HIS A N   1 
ATOM   3021 C CA  . HIS A 1 570 ? 9.088   49.680  89.593  1.00 73.39  ? 551 HIS A CA  1 
ATOM   3022 C C   . HIS A 1 570 ? 7.860   50.065  88.775  1.00 72.64  ? 551 HIS A C   1 
ATOM   3023 O O   . HIS A 1 570 ? 6.837   50.407  89.370  1.00 74.75  ? 551 HIS A O   1 
ATOM   3024 C CB  . HIS A 1 570 ? 9.492   50.875  90.453  1.00 67.87  ? 551 HIS A CB  1 
ATOM   3025 C CG  . HIS A 1 570 ? 10.564  50.544  91.430  1.00 68.82  ? 551 HIS A CG  1 
ATOM   3026 N ND1 . HIS A 1 570 ? 10.375  49.632  92.445  1.00 68.62  ? 551 HIS A ND1 1 
ATOM   3027 C CD2 . HIS A 1 570 ? 11.832  51.003  91.560  1.00 68.58  ? 551 HIS A CD2 1 
ATOM   3028 C CE1 . HIS A 1 570 ? 11.489  49.528  93.147  1.00 73.78  ? 551 HIS A CE1 1 
ATOM   3029 N NE2 . HIS A 1 570 ? 12.389  50.348  92.632  1.00 69.63  ? 551 HIS A NE2 1 
ATOM   3030 N N   . TRP A 1 571 ? 7.900   49.997  87.453  1.00 68.85  ? 552 TRP A N   1 
ATOM   3031 C CA  . TRP A 1 571 ? 6.795   50.543  86.672  1.00 70.07  ? 552 TRP A CA  1 
ATOM   3032 C C   . TRP A 1 571 ? 5.442   49.930  87.034  1.00 70.89  ? 552 TRP A C   1 
ATOM   3033 O O   . TRP A 1 571 ? 4.417   50.611  86.975  1.00 76.41  ? 552 TRP A O   1 
ATOM   3034 C CB  . TRP A 1 571 ? 7.085   50.355  85.181  1.00 77.64  ? 552 TRP A CB  1 
ATOM   3035 C CG  . TRP A 1 571 ? 6.828   48.972  84.667  1.00 76.79  ? 552 TRP A CG  1 
ATOM   3036 C CD1 . TRP A 1 571 ? 7.697   47.920  84.660  1.00 71.00  ? 552 TRP A CD1 1 
ATOM   3037 C CD2 . TRP A 1 571 ? 5.613   48.498  84.066  1.00 78.08  ? 552 TRP A CD2 1 
ATOM   3038 N NE1 . TRP A 1 571 ? 7.089   46.820  84.104  1.00 70.77  ? 552 TRP A NE1 1 
ATOM   3039 C CE2 . TRP A 1 571 ? 5.814   47.151  83.726  1.00 70.41  ? 552 TRP A CE2 1 
ATOM   3040 C CE3 . TRP A 1 571 ? 4.368   49.088  83.790  1.00 79.48  ? 552 TRP A CE3 1 
ATOM   3041 C CZ2 . TRP A 1 571 ? 4.825   46.382  83.131  1.00 68.89  ? 552 TRP A CZ2 1 
ATOM   3042 C CZ3 . TRP A 1 571 ? 3.386   48.314  83.181  1.00 78.47  ? 552 TRP A CZ3 1 
ATOM   3043 C CH2 . TRP A 1 571 ? 3.626   46.981  82.858  1.00 70.51  ? 552 TRP A CH2 1 
ATOM   3044 N N   . ASP A 1 572 ? 5.402   48.656  87.390  1.00 78.17  ? 553 ASP A N   1 
ATOM   3045 C CA  . ASP A 1 572 ? 4.144   48.001  87.712  1.00 80.87  ? 553 ASP A CA  1 
ATOM   3046 C C   . ASP A 1 572 ? 3.940   47.850  89.219  1.00 79.89  ? 553 ASP A C   1 
ATOM   3047 O O   . ASP A 1 572 ? 3.104   47.055  89.647  1.00 85.26  ? 553 ASP A O   1 
ATOM   3048 C CB  . ASP A 1 572 ? 4.039   46.634  87.007  1.00 80.36  ? 553 ASP A CB  1 
ATOM   3049 C CG  . ASP A 1 572 ? 5.225   45.664  87.334  1.00 84.04  ? 553 ASP A CG  1 
ATOM   3050 O OD1 . ASP A 1 572 ? 6.188   46.005  88.084  1.00 81.34  ? 553 ASP A OD1 1 
ATOM   3051 O OD2 . ASP A 1 572 ? 5.138   44.498  86.886  1.00 89.44  ? 553 ASP A OD2 1 
ATOM   3052 N N   . GLN A 1 573 ? 4.675   48.604  90.034  1.00 79.14  ? 554 GLN A N   1 
ATOM   3053 C CA  . GLN A 1 573 ? 4.583   48.440  91.485  1.00 85.56  ? 554 GLN A CA  1 
ATOM   3054 C C   . GLN A 1 573 ? 3.152   48.550  92.023  1.00 84.25  ? 554 GLN A C   1 
ATOM   3055 O O   . GLN A 1 573 ? 2.836   47.957  93.056  1.00 86.52  ? 554 GLN A O   1 
ATOM   3056 C CB  . GLN A 1 573 ? 5.472   49.461  92.172  1.00 77.43  ? 554 GLN A CB  1 
ATOM   3057 C CG  . GLN A 1 573 ? 5.074   50.865  91.839  1.00 81.87  ? 554 GLN A CG  1 
ATOM   3058 C CD  . GLN A 1 573 ? 4.360   51.553  92.975  1.00 86.37  ? 554 GLN A CD  1 
ATOM   3059 O OE1 . GLN A 1 573 ? 4.663   51.310  94.151  1.00 92.13  ? 554 GLN A OE1 1 
ATOM   3060 N NE2 . GLN A 1 573 ? 3.411   52.427  92.636  1.00 78.48  ? 554 GLN A NE2 1 
ATOM   3061 N N   . ASP A 1 574 ? 2.271   49.264  91.336  1.00 83.56  ? 555 ASP A N   1 
ATOM   3062 C CA  . ASP A 1 574 ? 0.887   49.398  91.783  1.00 85.11  ? 555 ASP A CA  1 
ATOM   3063 C C   . ASP A 1 574 ? -0.017  48.233  91.354  1.00 94.16  ? 555 ASP A C   1 
ATOM   3064 O O   . ASP A 1 574 ? -1.242  48.321  91.522  1.00 94.59  ? 555 ASP A O   1 
ATOM   3065 C CB  . ASP A 1 574 ? 0.308   50.724  91.268  1.00 84.68  ? 555 ASP A CB  1 
ATOM   3066 C CG  . ASP A 1 574 ? -0.022  50.697  89.787  1.00 91.35  ? 555 ASP A CG  1 
ATOM   3067 O OD1 . ASP A 1 574 ? 0.743   50.094  88.998  1.00 90.78  ? 555 ASP A OD1 1 
ATOM   3068 O OD2 . ASP A 1 574 ? -1.054  51.305  89.418  1.00 99.86  ? 555 ASP A OD2 1 
ATOM   3069 N N   . ASP A 1 575 ? 0.548   47.153  90.811  1.00 101.34 ? 556 ASP A N   1 
ATOM   3070 C CA  . ASP A 1 575 ? -0.232  46.101  90.162  1.00 105.44 ? 556 ASP A CA  1 
ATOM   3071 C C   . ASP A 1 575 ? -0.787  45.094  91.165  1.00 99.81  ? 556 ASP A C   1 
ATOM   3072 O O   . ASP A 1 575 ? -1.713  44.344  90.831  1.00 98.19  ? 556 ASP A O   1 
ATOM   3073 C CB  . ASP A 1 575 ? 0.640   45.399  89.092  1.00 107.99 ? 556 ASP A CB  1 
ATOM   3074 C CG  . ASP A 1 575 ? -0.161  44.874  87.888  1.00 120.89 ? 556 ASP A CG  1 
ATOM   3075 O OD1 . ASP A 1 575 ? -1.328  44.445  88.059  1.00 125.30 ? 556 ASP A OD1 1 
ATOM   3076 O OD2 . ASP A 1 575 ? 0.382   44.955  86.749  1.00 120.06 ? 556 ASP A OD2 1 
ATOM   3077 N N   . ASP A 1 576 ? -0.265  45.076  92.391  1.00 92.57  ? 557 ASP A N   1 
ATOM   3078 C CA  . ASP A 1 576 ? -0.866  44.214  93.396  1.00 96.19  ? 557 ASP A CA  1 
ATOM   3079 C C   . ASP A 1 576 ? -2.239  44.718  93.806  1.00 93.09  ? 557 ASP A C   1 
ATOM   3080 O O   . ASP A 1 576 ? -3.137  43.917  94.088  1.00 95.47  ? 557 ASP A O   1 
ATOM   3081 C CB  . ASP A 1 576 ? 0.050   44.100  94.608  1.00 96.90  ? 557 ASP A CB  1 
ATOM   3082 C CG  . ASP A 1 576 ? 1.287   43.252  94.321  1.00 116.24 ? 557 ASP A CG  1 
ATOM   3083 O OD1 . ASP A 1 576 ? 1.362   42.631  93.231  1.00 114.47 ? 557 ASP A OD1 1 
ATOM   3084 O OD2 . ASP A 1 576 ? 2.184   43.195  95.188  1.00 123.62 ? 557 ASP A OD2 1 
ATOM   3085 N N   . PHE A 1 577 ? -2.429  46.029  93.805  1.00 87.72  ? 558 PHE A N   1 
ATOM   3086 C CA  . PHE A 1 577 ? -3.636  46.630  94.333  1.00 80.39  ? 558 PHE A CA  1 
ATOM   3087 C C   . PHE A 1 577 ? -4.707  46.790  93.283  1.00 81.40  ? 558 PHE A C   1 
ATOM   3088 O O   . PHE A 1 577 ? -5.676  47.512  93.517  1.00 85.40  ? 558 PHE A O   1 
ATOM   3089 C CB  . PHE A 1 577 ? -3.296  47.969  94.982  1.00 75.29  ? 558 PHE A CB  1 
ATOM   3090 C CG  . PHE A 1 577 ? -2.116  47.894  95.916  1.00 75.17  ? 558 PHE A CG  1 
ATOM   3091 C CD1 . PHE A 1 577 ? -2.277  47.508  97.231  1.00 77.64  ? 558 PHE A CD1 1 
ATOM   3092 C CD2 . PHE A 1 577 ? -0.841  48.183  95.480  1.00 78.65  ? 558 PHE A CD2 1 
ATOM   3093 C CE1 . PHE A 1 577 ? -1.187  47.428  98.094  1.00 76.62  ? 558 PHE A CE1 1 
ATOM   3094 C CE2 . PHE A 1 577 ? 0.254   48.096  96.351  1.00 73.54  ? 558 PHE A CE2 1 
ATOM   3095 C CZ  . PHE A 1 577 ? 0.073   47.718  97.642  1.00 71.37  ? 558 PHE A CZ  1 
ATOM   3096 N N   . GLU A 1 578 ? -4.555  46.132  92.139  1.00 88.89  ? 559 GLU A N   1 
ATOM   3097 C CA  . GLU A 1 578 ? -5.596  46.135  91.122  1.00 89.72  ? 559 GLU A CA  1 
ATOM   3098 C C   . GLU A 1 578 ? -6.924  45.763  91.755  1.00 82.29  ? 559 GLU A C   1 
ATOM   3099 O O   . GLU A 1 578 ? -7.008  44.840  92.565  1.00 84.19  ? 559 GLU A O   1 
ATOM   3100 C CB  . GLU A 1 578 ? -5.243  45.141  90.009  1.00 101.29 ? 559 GLU A CB  1 
ATOM   3101 C CG  . GLU A 1 578 ? -6.021  45.263  88.678  1.00 109.54 ? 559 GLU A CG  1 
ATOM   3102 C CD  . GLU A 1 578 ? -5.671  46.488  87.847  1.00 115.98 ? 559 GLU A CD  1 
ATOM   3103 O OE1 . GLU A 1 578 ? -4.677  47.184  88.183  1.00 113.95 ? 559 GLU A OE1 1 
ATOM   3104 O OE2 . GLU A 1 578 ? -6.376  46.728  86.835  1.00 119.42 ? 559 GLU A OE2 1 
ATOM   3105 N N   . PHE A 1 579 ? -7.953  46.515  91.423  1.00 83.98  ? 560 PHE A N   1 
ATOM   3106 C CA  . PHE A 1 579 ? -9.281  46.075  91.797  1.00 85.37  ? 560 PHE A CA  1 
ATOM   3107 C C   . PHE A 1 579 ? -9.689  44.862  90.965  1.00 89.57  ? 560 PHE A C   1 
ATOM   3108 O O   . PHE A 1 579 ? -9.317  44.717  89.792  1.00 94.67  ? 560 PHE A O   1 
ATOM   3109 C CB  . PHE A 1 579 ? -10.294 47.195  91.593  1.00 84.61  ? 560 PHE A CB  1 
ATOM   3110 C CG  . PHE A 1 579 ? -9.981  48.440  92.358  1.00 86.92  ? 560 PHE A CG  1 
ATOM   3111 C CD1 . PHE A 1 579 ? -9.441  48.362  93.640  1.00 80.93  ? 560 PHE A CD1 1 
ATOM   3112 C CD2 . PHE A 1 579 ? -10.246 49.703  91.801  1.00 82.03  ? 560 PHE A CD2 1 
ATOM   3113 C CE1 . PHE A 1 579 ? -9.161  49.513  94.350  1.00 75.33  ? 560 PHE A CE1 1 
ATOM   3114 C CE2 . PHE A 1 579 ? -9.976  50.871  92.515  1.00 73.99  ? 560 PHE A CE2 1 
ATOM   3115 C CZ  . PHE A 1 579 ? -9.432  50.778  93.779  1.00 74.17  ? 560 PHE A CZ  1 
ATOM   3116 N N   . THR A 1 580 ? -10.471 43.989  91.580  1.00 84.86  ? 561 THR A N   1 
ATOM   3117 C CA  . THR A 1 580 ? -11.080 42.906  90.838  1.00 87.42  ? 561 THR A CA  1 
ATOM   3118 C C   . THR A 1 580 ? -12.290 43.417  90.058  1.00 85.69  ? 561 THR A C   1 
ATOM   3119 O O   . THR A 1 580 ? -12.872 44.462  90.359  1.00 86.84  ? 561 THR A O   1 
ATOM   3120 C CB  . THR A 1 580 ? -11.518 41.790  91.776  1.00 86.29  ? 561 THR A CB  1 
ATOM   3121 O OG1 . THR A 1 580 ? -12.797 42.129  92.317  1.00 86.00  ? 561 THR A OG1 1 
ATOM   3122 C CG2 . THR A 1 580 ? -10.503 41.608  92.912  1.00 78.12  ? 561 THR A CG2 1 
ATOM   3123 N N   . GLY A 1 581 ? -12.668 42.663  89.044  1.00 84.14  ? 562 GLY A N   1 
ATOM   3124 C CA  . GLY A 1 581 ? -13.776 43.091  88.224  1.00 85.05  ? 562 GLY A CA  1 
ATOM   3125 C C   . GLY A 1 581 ? -13.302 43.634  86.893  1.00 86.99  ? 562 GLY A C   1 
ATOM   3126 O O   . GLY A 1 581 ? -12.115 43.904  86.673  1.00 86.65  ? 562 GLY A O   1 
ATOM   3127 N N   . SER A 1 582 ? -14.244 43.768  85.984  1.00 84.43  ? 563 SER A N   1 
ATOM   3128 C CA  . SER A 1 582 ? -13.895 44.178  84.644  1.00 88.96  ? 563 SER A CA  1 
ATOM   3129 C C   . SER A 1 582 ? -14.033 45.682  84.537  1.00 89.40  ? 563 SER A C   1 
ATOM   3130 O O   . SER A 1 582 ? -14.988 46.272  85.036  1.00 92.05  ? 563 SER A O   1 
ATOM   3131 C CB  . SER A 1 582 ? -14.766 43.457  83.617  1.00 100.22 ? 563 SER A CB  1 
ATOM   3132 O OG  . SER A 1 582 ? -16.141 43.669  83.883  1.00 106.57 ? 563 SER A OG  1 
ATOM   3133 N N   . HIS A 1 583 ? -13.043 46.294  83.922  1.00 86.68  ? 564 HIS A N   1 
ATOM   3134 C CA  . HIS A 1 583 ? -13.031 47.728  83.716  1.00 84.83  ? 564 HIS A CA  1 
ATOM   3135 C C   . HIS A 1 583 ? -14.258 48.176  82.920  1.00 90.32  ? 564 HIS A C   1 
ATOM   3136 O O   . HIS A 1 583 ? -14.698 47.496  81.993  1.00 96.69  ? 564 HIS A O   1 
ATOM   3137 C CB  . HIS A 1 583 ? -11.730 48.060  83.005  1.00 82.81  ? 564 HIS A CB  1 
ATOM   3138 C CG  . HIS A 1 583 ? -10.526 47.788  83.846  1.00 85.64  ? 564 HIS A CG  1 
ATOM   3139 N ND1 . HIS A 1 583 ? -10.381 46.619  84.560  1.00 93.01  ? 564 HIS A ND1 1 
ATOM   3140 C CD2 . HIS A 1 583 ? -9.371  48.472  84.011  1.00 95.13  ? 564 HIS A CD2 1 
ATOM   3141 C CE1 . HIS A 1 583 ? -9.219  46.624  85.186  1.00 96.17  ? 564 HIS A CE1 1 
ATOM   3142 N NE2 . HIS A 1 583 ? -8.583  47.736  84.866  1.00 98.48  ? 564 HIS A NE2 1 
ATOM   3143 N N   . LEU A 1 584 ? -14.820 49.323  83.295  1.00 91.33  ? 565 LEU A N   1 
ATOM   3144 C CA  . LEU A 1 584 ? -16.034 49.856  82.694  1.00 89.95  ? 565 LEU A CA  1 
ATOM   3145 C C   . LEU A 1 584 ? -15.755 51.232  82.121  1.00 89.65  ? 565 LEU A C   1 
ATOM   3146 O O   . LEU A 1 584 ? -14.709 51.830  82.368  1.00 92.15  ? 565 LEU A O   1 
ATOM   3147 C CB  . LEU A 1 584 ? -17.159 49.978  83.715  1.00 88.95  ? 565 LEU A CB  1 
ATOM   3148 C CG  . LEU A 1 584 ? -17.452 48.724  84.518  1.00 91.89  ? 565 LEU A CG  1 
ATOM   3149 C CD1 . LEU A 1 584 ? -16.579 48.666  85.751  1.00 85.21  ? 565 LEU A CD1 1 
ATOM   3150 C CD2 . LEU A 1 584 ? -18.900 48.765  84.909  1.00 100.45 ? 565 LEU A CD2 1 
ATOM   3151 N N   . THR A 1 585 ? -16.706 51.741  81.356  1.00 91.77  ? 566 THR A N   1 
ATOM   3152 C CA  . THR A 1 585 ? -16.641 53.105  80.855  1.00 90.28  ? 566 THR A CA  1 
ATOM   3153 C C   . THR A 1 585 ? -17.878 53.847  81.327  1.00 95.61  ? 566 THR A C   1 
ATOM   3154 O O   . THR A 1 585 ? -18.870 53.239  81.740  1.00 98.22  ? 566 THR A O   1 
ATOM   3155 C CB  . THR A 1 585 ? -16.540 53.160  79.320  1.00 91.89  ? 566 THR A CB  1 
ATOM   3156 O OG1 . THR A 1 585 ? -17.766 52.710  78.721  1.00 93.56  ? 566 THR A OG1 1 
ATOM   3157 C CG2 . THR A 1 585 ? -15.385 52.299  78.842  1.00 92.56  ? 566 THR A CG2 1 
ATOM   3158 N N   . VAL A 1 586 ? -17.805 55.171  81.296  1.00 95.87  ? 567 VAL A N   1 
ATOM   3159 C CA  . VAL A 1 586 ? -18.910 56.006  81.739  1.00 96.73  ? 567 VAL A CA  1 
ATOM   3160 C C   . VAL A 1 586 ? -19.603 56.479  80.484  1.00 100.83 ? 567 VAL A C   1 
ATOM   3161 O O   . VAL A 1 586 ? -19.039 57.272  79.718  1.00 100.86 ? 567 VAL A O   1 
ATOM   3162 C CB  . VAL A 1 586 ? -18.444 57.179  82.605  1.00 93.51  ? 567 VAL A CB  1 
ATOM   3163 C CG1 . VAL A 1 586 ? -19.524 58.245  82.657  1.00 99.41  ? 567 VAL A CG1 1 
ATOM   3164 C CG2 . VAL A 1 586 ? -18.111 56.692  83.998  1.00 88.38  ? 567 VAL A CG2 1 
ATOM   3165 N N   . ARG A 1 587 ? -20.865 56.104  80.357  1.00 105.84 ? 568 ARG A N   1 
ATOM   3166 C CA  . ARG A 1 587 ? -21.615 56.458  79.137  1.00 112.94 ? 568 ARG A CA  1 
ATOM   3167 C C   . ARG A 1 587 ? -22.050 57.918  79.154  1.00 110.98 ? 568 ARG A C   1 
ATOM   3168 O O   . ARG A 1 587 ? -22.082 58.493  78.079  1.00 109.44 ? 568 ARG A O   1 
ATOM   3169 C CB  . ARG A 1 587 ? -22.827 55.543  78.988  1.00 115.20 ? 568 ARG A CB  1 
ATOM   3170 C CG  . ARG A 1 587 ? -22.868 54.790  77.669  1.00 123.67 ? 568 ARG A CG  1 
ATOM   3171 C CD  . ARG A 1 587 ? -24.253 54.771  77.063  1.00 125.66 ? 568 ARG A CD  1 
ATOM   3172 N NE  . ARG A 1 587 ? -24.669 53.403  76.855  1.00 126.63 ? 568 ARG A NE  1 
ATOM   3173 C CZ  . ARG A 1 587 ? -24.298 52.669  75.826  1.00 127.83 ? 568 ARG A CZ  1 
ATOM   3174 N NH1 . ARG A 1 587 ? -23.509 53.179  74.904  1.00 125.55 ? 568 ARG A NH1 1 
ATOM   3175 N NH2 . ARG A 1 587 ? -24.714 51.425  75.719  1.00 128.34 ? 568 ARG A NH2 1 
ATOM   3176 N N   . ASN A 1 588 ? -22.372 58.496  80.307  1.00 105.23 ? 569 ASN A N   1 
ATOM   3177 C CA  . ASN A 1 588 ? -22.862 59.896  80.265  1.00 105.26 ? 569 ASN A CA  1 
ATOM   3178 C C   . ASN A 1 588 ? -21.704 60.845  80.495  1.00 103.69 ? 569 ASN A C   1 
ATOM   3179 O O   . ASN A 1 588 ? -21.947 61.998  80.817  1.00 109.32 ? 569 ASN A O   1 
ATOM   3180 C CB  . ASN A 1 588 ? -23.869 60.178  81.364  1.00 106.48 ? 569 ASN A CB  1 
ATOM   3181 C CG  . ASN A 1 588 ? -23.564 59.318  82.557  1.00 114.77 ? 569 ASN A CG  1 
ATOM   3182 O OD1 . ASN A 1 588 ? -22.724 58.440  82.459  1.00 114.25 ? 569 ASN A OD1 1 
ATOM   3183 N ND2 . ASN A 1 588 ? -24.241 59.555  83.663  1.00 113.51 ? 569 ASN A ND2 1 
ATOM   3184 N N   . GLY A 1 589 ? -20.484 60.352  80.392  1.00 97.19  ? 570 GLY A N   1 
ATOM   3185 C CA  . GLY A 1 589 ? -19.328 61.232  80.604  1.00 94.11  ? 570 GLY A CA  1 
ATOM   3186 C C   . GLY A 1 589 ? -18.840 61.138  82.027  1.00 97.22  ? 570 GLY A C   1 
ATOM   3187 O O   . GLY A 1 589 ? -19.647 61.072  82.930  1.00 102.41 ? 570 GLY A O   1 
ATOM   3188 N N   . TYR A 1 590 ? -17.537 61.241  82.247  1.00 87.07  ? 571 TYR A N   1 
ATOM   3189 C CA  . TYR A 1 590 ? -17.030 61.128  83.634  1.00 85.47  ? 571 TYR A CA  1 
ATOM   3190 C C   . TYR A 1 590 ? -17.241 62.464  84.342  1.00 87.84  ? 571 TYR A C   1 
ATOM   3191 O O   . TYR A 1 590 ? -17.367 62.477  85.543  1.00 81.90  ? 571 TYR A O   1 
ATOM   3192 C CB  . TYR A 1 590 ? -15.578 60.663  83.596  1.00 81.00  ? 571 TYR A CB  1 
ATOM   3193 C CG  . TYR A 1 590 ? -15.104 59.745  84.690  1.00 76.90  ? 571 TYR A CG  1 
ATOM   3194 C CD1 . TYR A 1 590 ? -15.764 59.615  85.886  1.00 75.51  ? 571 TYR A CD1 1 
ATOM   3195 C CD2 . TYR A 1 590 ? -13.944 59.034  84.524  1.00 73.59  ? 571 TYR A CD2 1 
ATOM   3196 C CE1 . TYR A 1 590 ? -15.294 58.779  86.879  1.00 76.46  ? 571 TYR A CE1 1 
ATOM   3197 C CE2 . TYR A 1 590 ? -13.457 58.201  85.504  1.00 71.61  ? 571 TYR A CE2 1 
ATOM   3198 C CZ  . TYR A 1 590 ? -14.134 58.069  86.685  1.00 76.46  ? 571 TYR A CZ  1 
ATOM   3199 O OH  . TYR A 1 590 ? -13.622 57.242  87.625  1.00 68.89  ? 571 TYR A OH  1 
ATOM   3200 N N   . SER A 1 591 ? -17.427 63.548  83.590  1.00 85.57  ? 572 SER A N   1 
ATOM   3201 C CA  . SER A 1 591 ? -17.670 64.918  84.100  1.00 79.00  ? 572 SER A CA  1 
ATOM   3202 C C   . SER A 1 591 ? -18.728 64.942  85.197  1.00 81.00  ? 572 SER A C   1 
ATOM   3203 O O   . SER A 1 591 ? -18.529 65.625  86.153  1.00 86.08  ? 572 SER A O   1 
ATOM   3204 C CB  . SER A 1 591 ? -17.999 65.847  82.983  1.00 80.77  ? 572 SER A CB  1 
ATOM   3205 O OG  . SER A 1 591 ? -19.365 66.199  82.988  1.00 79.26  ? 572 SER A OG  1 
ATOM   3206 N N   . CYS A 1 592 ? -19.808 64.193  85.091  1.00 78.87  ? 573 CYS A N   1 
ATOM   3207 C CA  . CYS A 1 592 ? -20.847 64.187  86.142  1.00 86.82  ? 573 CYS A CA  1 
ATOM   3208 C C   . CYS A 1 592 ? -20.305 63.912  87.546  1.00 86.03  ? 573 CYS A C   1 
ATOM   3209 O O   . CYS A 1 592 ? -20.895 64.432  88.462  1.00 89.17  ? 573 CYS A O   1 
ATOM   3210 C CB  . CYS A 1 592 ? -21.895 63.144  85.817  1.00 94.88  ? 573 CYS A CB  1 
ATOM   3211 S SG  . CYS A 1 592 ? -21.240 61.468  85.908  1.00 106.26 ? 573 CYS A SG  1 
ATOM   3212 N N   . VAL A 1 593 ? -19.286 63.084  87.743  1.00 82.15  ? 574 VAL A N   1 
ATOM   3213 C CA  . VAL A 1 593 ? -18.801 62.855  89.130  1.00 81.93  ? 574 VAL A CA  1 
ATOM   3214 C C   . VAL A 1 593 ? -18.326 64.168  89.729  1.00 78.19  ? 574 VAL A C   1 
ATOM   3215 O O   . VAL A 1 593 ? -18.871 64.575  90.724  1.00 76.38  ? 574 VAL A O   1 
ATOM   3216 C CB  . VAL A 1 593 ? -17.694 61.802  89.158  1.00 78.05  ? 574 VAL A CB  1 
ATOM   3217 C CG1 . VAL A 1 593 ? -16.936 61.838  90.460  1.00 66.77  ? 574 VAL A CG1 1 
ATOM   3218 C CG2 . VAL A 1 593 ? -18.288 60.432  88.966  1.00 79.78  ? 574 VAL A CG2 1 
ATOM   3219 N N   . PRO A 1 594 ? -17.280 64.789  89.179  1.00 75.20  ? 575 PRO A N   1 
ATOM   3220 C CA  . PRO A 1 594 ? -16.757 66.039  89.649  1.00 77.25  ? 575 PRO A CA  1 
ATOM   3221 C C   . PRO A 1 594 ? -17.848 67.061  89.902  1.00 79.74  ? 575 PRO A C   1 
ATOM   3222 O O   . PRO A 1 594 ? -17.940 67.524  90.963  1.00 83.07  ? 575 PRO A O   1 
ATOM   3223 C CB  . PRO A 1 594 ? -16.101 66.524  88.377  1.00 75.60  ? 575 PRO A CB  1 
ATOM   3224 C CG  . PRO A 1 594 ? -15.454 65.306  87.882  1.00 75.72  ? 575 PRO A CG  1 
ATOM   3225 C CD  . PRO A 1 594 ? -16.459 64.219  88.157  1.00 81.12  ? 575 PRO A CD  1 
ATOM   3226 N N   . VAL A 1 595 ? -18.660 67.296  88.894  1.00 80.21  ? 576 VAL A N   1 
ATOM   3227 C CA  . VAL A 1 595 ? -19.745 68.293  89.001  1.00 78.37  ? 576 VAL A CA  1 
ATOM   3228 C C   . VAL A 1 595 ? -20.617 67.907  90.171  1.00 80.37  ? 576 VAL A C   1 
ATOM   3229 O O   . VAL A 1 595 ? -21.040 68.770  90.876  1.00 85.43  ? 576 VAL A O   1 
ATOM   3230 C CB  . VAL A 1 595 ? -20.565 68.292  87.716  1.00 74.11  ? 576 VAL A CB  1 
ATOM   3231 C CG1 . VAL A 1 595 ? -21.617 69.367  87.757  1.00 76.33  ? 576 VAL A CG1 1 
ATOM   3232 C CG2 . VAL A 1 595 ? -19.660 68.481  86.531  1.00 65.44  ? 576 VAL A CG2 1 
ATOM   3233 N N   . ALA A 1 596 ? -20.745 66.625  90.437  1.00 75.88  ? 577 ALA A N   1 
ATOM   3234 C CA  . ALA A 1 596 ? -21.636 66.253  91.545  1.00 80.39  ? 577 ALA A CA  1 
ATOM   3235 C C   . ALA A 1 596 ? -20.931 66.473  92.868  1.00 85.47  ? 577 ALA A C   1 
ATOM   3236 O O   . ALA A 1 596 ? -21.598 66.655  93.845  1.00 91.22  ? 577 ALA A O   1 
ATOM   3237 C CB  . ALA A 1 596 ? -22.041 64.825  91.408  1.00 83.38  ? 577 ALA A CB  1 
ATOM   3238 N N   . LEU A 1 597 ? -19.612 66.466  92.878  1.00 84.55  ? 578 LEU A N   1 
ATOM   3239 C CA  . LEU A 1 597 ? -18.896 66.634  94.152  1.00 76.16  ? 578 LEU A CA  1 
ATOM   3240 C C   . LEU A 1 597 ? -18.838 68.105  94.514  1.00 83.25  ? 578 LEU A C   1 
ATOM   3241 O O   . LEU A 1 597 ? -18.683 68.385  95.675  1.00 85.71  ? 578 LEU A O   1 
ATOM   3242 C CB  . LEU A 1 597 ? -17.491 66.084  93.969  1.00 72.83  ? 578 LEU A CB  1 
ATOM   3243 C CG  . LEU A 1 597 ? -17.418 64.573  93.883  1.00 71.02  ? 578 LEU A CG  1 
ATOM   3244 C CD1 . LEU A 1 597 ? -15.984 64.126  93.872  1.00 67.53  ? 578 LEU A CD1 1 
ATOM   3245 C CD2 . LEU A 1 597 ? -18.133 63.954  95.050  1.00 71.61  ? 578 LEU A CD2 1 
ATOM   3246 N N   . ALA A 1 598 ? -19.029 68.997  93.553  1.00 77.66  ? 579 ALA A N   1 
ATOM   3247 C CA  . ALA A 1 598 ? -18.938 70.447  93.810  1.00 79.57  ? 579 ALA A CA  1 
ATOM   3248 C C   . ALA A 1 598 ? -20.226 71.013  94.398  1.00 85.49  ? 579 ALA A C   1 
ATOM   3249 O O   . ALA A 1 598 ? -20.246 72.174  94.745  1.00 82.27  ? 579 ALA A O   1 
ATOM   3250 C CB  . ALA A 1 598 ? -18.615 71.124  92.523  1.00 71.91  ? 579 ALA A CB  1 
ATOM   3251 N N   . GLU A 1 599 ? -21.276 70.221  94.465  1.00 89.45  ? 580 GLU A N   1 
ATOM   3252 C CA  . GLU A 1 599 ? -22.548 70.709  95.017  1.00 93.54  ? 580 GLU A CA  1 
ATOM   3253 C C   . GLU A 1 599 ? -22.309 71.220  96.428  1.00 94.97  ? 580 GLU A C   1 
ATOM   3254 O O   . GLU A 1 599 ? -21.975 70.417  97.284  1.00 91.89  ? 580 GLU A O   1 
ATOM   3255 C CB  . GLU A 1 599 ? -23.542 69.558  95.080  1.00 97.61  ? 580 GLU A CB  1 
ATOM   3256 C CG  . GLU A 1 599 ? -24.981 70.007  95.179  1.00 109.51 ? 580 GLU A CG  1 
ATOM   3257 C CD  . GLU A 1 599 ? -25.870 69.029  95.922  1.00 121.99 ? 580 GLU A CD  1 
ATOM   3258 O OE1 . GLU A 1 599 ? -27.041 68.865  95.523  1.00 124.55 ? 580 GLU A OE1 1 
ATOM   3259 O OE2 . GLU A 1 599 ? -25.389 68.437  96.897  1.00 118.86 ? 580 GLU A OE2 1 
ATOM   3260 N N   . GLY A 1 600 ? -22.424 72.530  96.609  1.00 96.21  ? 581 GLY A N   1 
ATOM   3261 C CA  . GLY A 1 600 ? -22.341 73.158  97.936  1.00 90.93  ? 581 GLY A CA  1 
ATOM   3262 C C   . GLY A 1 600 ? -20.944 73.540  98.338  1.00 85.41  ? 581 GLY A C   1 
ATOM   3263 O O   . GLY A 1 600 ? -20.714 73.646  99.520  1.00 92.56  ? 581 GLY A O   1 
ATOM   3264 N N   . LEU A 1 601 ? -20.074 73.818  97.385  1.00 74.10  ? 582 LEU A N   1 
ATOM   3265 C CA  . LEU A 1 601 ? -18.686 74.137  97.761  1.00 76.59  ? 582 LEU A CA  1 
ATOM   3266 C C   . LEU A 1 601 ? -18.323 75.528  97.266  1.00 77.75  ? 582 LEU A C   1 
ATOM   3267 O O   . LEU A 1 601 ? -18.752 75.884  96.189  1.00 77.92  ? 582 LEU A O   1 
ATOM   3268 C CB  . LEU A 1 601 ? -17.798 73.119  97.058  1.00 81.76  ? 582 LEU A CB  1 
ATOM   3269 C CG  . LEU A 1 601 ? -17.694 71.744  97.695  1.00 81.31  ? 582 LEU A CG  1 
ATOM   3270 C CD1 . LEU A 1 601 ? -16.272 71.259  97.615  1.00 78.73  ? 582 LEU A CD1 1 
ATOM   3271 C CD2 . LEU A 1 601 ? -18.130 71.780  99.129  1.00 83.07  ? 582 LEU A CD2 1 
ATOM   3272 N N   . ASP A 1 602 ? -17.509 76.248  98.029  1.00 79.85  ? 583 ASP A N   1 
ATOM   3273 C CA  . ASP A 1 602 ? -17.050 77.601  97.633  1.00 84.98  ? 583 ASP A CA  1 
ATOM   3274 C C   . ASP A 1 602 ? -15.930 77.400  96.634  1.00 83.17  ? 583 ASP A C   1 
ATOM   3275 O O   . ASP A 1 602 ? -14.845 77.087  97.046  1.00 85.19  ? 583 ASP A O   1 
ATOM   3276 C CB  . ASP A 1 602 ? -16.484 78.352  98.826  1.00 83.54  ? 583 ASP A CB  1 
ATOM   3277 C CG  . ASP A 1 602 ? -16.435 79.846  98.619  1.00 97.64  ? 583 ASP A CG  1 
ATOM   3278 O OD1 . ASP A 1 602 ? -15.969 80.537  99.522  1.00 104.88 ? 583 ASP A OD1 1 
ATOM   3279 O OD2 . ASP A 1 602 ? -16.860 80.295  97.557  1.00 103.81 ? 583 ASP A OD2 1 
ATOM   3280 N N   . ILE A 1 603 ? -16.220 77.552  95.354  1.00 77.14  ? 584 ILE A N   1 
ATOM   3281 C CA  . ILE A 1 603 ? -15.252 77.271  94.316  1.00 78.05  ? 584 ILE A CA  1 
ATOM   3282 C C   . ILE A 1 603 ? -15.084 78.524  93.484  1.00 76.70  ? 584 ILE A C   1 
ATOM   3283 O O   . ILE A 1 603 ? -16.005 78.929  92.769  1.00 81.93  ? 584 ILE A O   1 
ATOM   3284 C CB  . ILE A 1 603 ? -15.670 76.077  93.451  1.00 75.94  ? 584 ILE A CB  1 
ATOM   3285 C CG1 . ILE A 1 603 ? -16.049 74.914  94.355  1.00 75.72  ? 584 ILE A CG1 1 
ATOM   3286 C CG2 . ILE A 1 603 ? -14.534 75.652  92.571  1.00 79.12  ? 584 ILE A CG2 1 
ATOM   3287 C CD1 . ILE A 1 603 ? -16.088 73.612  93.683  1.00 81.42  ? 584 ILE A CD1 1 
ATOM   3288 N N   . LYS A 1 604 ? -13.913 79.132  93.566  1.00 73.18  ? 585 LYS A N   1 
ATOM   3289 C CA  . LYS A 1 604 ? -13.587 80.302  92.764  1.00 76.46  ? 585 LYS A CA  1 
ATOM   3290 C C   . LYS A 1 604 ? -12.931 79.829  91.470  1.00 76.11  ? 585 LYS A C   1 
ATOM   3291 O O   . LYS A 1 604 ? -11.797 79.342  91.498  1.00 76.75  ? 585 LYS A O   1 
ATOM   3292 C CB  . LYS A 1 604 ? -12.662 81.225  93.558  1.00 76.58  ? 585 LYS A CB  1 
ATOM   3293 C CG  . LYS A 1 604 ? -13.197 81.608  94.962  1.00 78.01  ? 585 LYS A CG  1 
ATOM   3294 C CD  . LYS A 1 604 ? -14.173 82.798  94.924  1.00 85.40  ? 585 LYS A CD  1 
ATOM   3295 C CE  . LYS A 1 604 ? -14.987 82.919  96.204  1.00 90.33  ? 585 LYS A CE  1 
ATOM   3296 N NZ  . LYS A 1 604 ? -16.158 81.978  96.219  1.00 87.77  ? 585 LYS A NZ  1 
ATOM   3297 N N   . LEU A 1 605 ? -13.641 79.941  90.334  1.00 79.89  ? 586 LEU A N   1 
ATOM   3298 C CA  . LEU A 1 605 ? -13.069 79.533  89.047  1.00 74.94  ? 586 LEU A CA  1 
ATOM   3299 C C   . LEU A 1 605 ? -12.416 80.719  88.376  1.00 71.89  ? 586 LEU A C   1 
ATOM   3300 O O   . LEU A 1 605 ? -12.656 81.869  88.733  1.00 78.07  ? 586 LEU A O   1 
ATOM   3301 C CB  . LEU A 1 605 ? -14.104 78.920  88.091  1.00 65.84  ? 586 LEU A CB  1 
ATOM   3302 C CG  . LEU A 1 605 ? -15.139 77.931  88.646  1.00 70.03  ? 586 LEU A CG  1 
ATOM   3303 C CD1 . LEU A 1 605 ? -16.195 77.549  87.644  1.00 65.96  ? 586 LEU A CD1 1 
ATOM   3304 C CD2 . LEU A 1 605 ? -14.466 76.685  89.145  1.00 75.43  ? 586 LEU A CD2 1 
ATOM   3305 N N   . ASN A 1 606 ? -11.577 80.426  87.395  1.00 72.60  ? 587 ASN A N   1 
ATOM   3306 C CA  . ASN A 1 606 ? -10.837 81.460  86.679  1.00 77.42  ? 587 ASN A CA  1 
ATOM   3307 C C   . ASN A 1 606 ? -9.904  82.185  87.628  1.00 74.61  ? 587 ASN A C   1 
ATOM   3308 O O   . ASN A 1 606 ? -9.625  83.376  87.472  1.00 74.30  ? 587 ASN A O   1 
ATOM   3309 C CB  . ASN A 1 606 ? -11.774 82.438  85.984  1.00 82.75  ? 587 ASN A CB  1 
ATOM   3310 C CG  . ASN A 1 606 ? -12.780 81.736  85.121  1.00 84.86  ? 587 ASN A CG  1 
ATOM   3311 O OD1 . ASN A 1 606 ? -12.437 81.206  84.054  1.00 90.92  ? 587 ASN A OD1 1 
ATOM   3312 N ND2 . ASN A 1 606 ? -14.029 81.696  85.581  1.00 78.65  ? 587 ASN A ND2 1 
ATOM   3313 N N   . THR A 1 607 ? -9.408  81.428  88.602  1.00 74.67  ? 588 THR A N   1 
ATOM   3314 C CA  . THR A 1 607 ? -8.604  81.924  89.710  1.00 68.03  ? 588 THR A CA  1 
ATOM   3315 C C   . THR A 1 607 ? -7.295  81.146  89.649  1.00 67.71  ? 588 THR A C   1 
ATOM   3316 O O   . THR A 1 607 ? -7.224  79.999  90.095  1.00 71.50  ? 588 THR A O   1 
ATOM   3317 C CB  . THR A 1 607 ? -9.314  81.667  91.016  1.00 70.29  ? 588 THR A CB  1 
ATOM   3318 O OG1 . THR A 1 607 ? -10.718 81.872  90.847  1.00 70.76  ? 588 THR A OG1 1 
ATOM   3319 C CG2 . THR A 1 607 ? -8.817  82.627  92.042  1.00 75.41  ? 588 THR A CG2 1 
ATOM   3320 N N   . ALA A 1 608 ? -6.259  81.726  89.088  1.00 65.20  ? 589 ALA A N   1 
ATOM   3321 C CA  . ALA A 1 608 ? -4.998  81.014  88.957  1.00 65.21  ? 589 ALA A CA  1 
ATOM   3322 C C   . ALA A 1 608 ? -4.103  81.336  90.148  1.00 69.64  ? 589 ALA A C   1 
ATOM   3323 O O   . ALA A 1 608 ? -3.631  82.469  90.292  1.00 70.88  ? 589 ALA A O   1 
ATOM   3324 C CB  . ALA A 1 608 ? -4.320  81.385  87.646  1.00 68.41  ? 589 ALA A CB  1 
ATOM   3325 N N   . VAL A 1 609 ? -3.831  80.340  90.986  1.00 63.35  ? 590 VAL A N   1 
ATOM   3326 C CA  . VAL A 1 609 ? -2.860  80.557  92.047  1.00 63.16  ? 590 VAL A CA  1 
ATOM   3327 C C   . VAL A 1 609 ? -1.482  80.800  91.449  1.00 68.04  ? 590 VAL A C   1 
ATOM   3328 O O   . VAL A 1 609 ? -1.032  80.060  90.564  1.00 71.99  ? 590 VAL A O   1 
ATOM   3329 C CB  . VAL A 1 609 ? -2.823  79.363  92.999  1.00 62.50  ? 590 VAL A CB  1 
ATOM   3330 C CG1 . VAL A 1 609 ? -1.611  79.495  93.915  1.00 59.34  ? 590 VAL A CG1 1 
ATOM   3331 C CG2 . VAL A 1 609 ? -4.152  79.254  93.774  1.00 60.10  ? 590 VAL A CG2 1 
ATOM   3332 N N   . ARG A 1 610 ? -0.801  81.838  91.924  1.00 69.36  ? 591 ARG A N   1 
ATOM   3333 C CA  . ARG A 1 610 ? 0.566   82.096  91.505  1.00 71.63  ? 591 ARG A CA  1 
ATOM   3334 C C   . ARG A 1 610 ? 1.577   82.067  92.619  1.00 68.19  ? 591 ARG A C   1 
ATOM   3335 O O   . ARG A 1 610 ? 2.758   81.834  92.349  1.00 70.21  ? 591 ARG A O   1 
ATOM   3336 C CB  . ARG A 1 610 ? 0.697   83.445  90.800  1.00 72.29  ? 591 ARG A CB  1 
ATOM   3337 C CG  . ARG A 1 610 ? 0.071   83.436  89.451  1.00 89.92  ? 591 ARG A CG  1 
ATOM   3338 C CD  . ARG A 1 610 ? 0.343   84.740  88.807  1.00 95.65  ? 591 ARG A CD  1 
ATOM   3339 N NE  . ARG A 1 610 ? -0.200  84.873  87.468  1.00 96.48  ? 591 ARG A NE  1 
ATOM   3340 C CZ  . ARG A 1 610 ? -0.080  86.016  86.795  1.00 109.39 ? 591 ARG A CZ  1 
ATOM   3341 N NH1 . ARG A 1 610 ? 0.545   87.053  87.364  1.00 110.27 ? 591 ARG A NH1 1 
ATOM   3342 N NH2 . ARG A 1 610 ? -0.587  86.134  85.565  1.00 115.02 ? 591 ARG A NH2 1 
ATOM   3343 N N   . GLN A 1 611 ? 1.172   82.306  93.851  1.00 65.37  ? 592 GLN A N   1 
ATOM   3344 C CA  . GLN A 1 611 ? 2.136   82.240  94.925  1.00 63.22  ? 592 GLN A CA  1 
ATOM   3345 C C   . GLN A 1 611 ? 1.476   81.604  96.126  1.00 63.95  ? 592 GLN A C   1 
ATOM   3346 O O   . GLN A 1 611 ? 0.350   81.969  96.474  1.00 65.97  ? 592 GLN A O   1 
ATOM   3347 C CB  . GLN A 1 611 ? 2.642   83.620  95.259  1.00 67.33  ? 592 GLN A CB  1 
ATOM   3348 C CG  . GLN A 1 611 ? 3.792   83.643  96.183  1.00 71.21  ? 592 GLN A CG  1 
ATOM   3349 C CD  . GLN A 1 611 ? 4.444   84.980  96.162  1.00 72.51  ? 592 GLN A CD  1 
ATOM   3350 O OE1 . GLN A 1 611 ? 4.431   85.697  97.157  1.00 71.77  ? 592 GLN A OE1 1 
ATOM   3351 N NE2 . GLN A 1 611 ? 5.001   85.348  95.016  1.00 80.69  ? 592 GLN A NE2 1 
ATOM   3352 N N   . VAL A 1 612 ? 2.160   80.638  96.733  1.00 61.47  ? 593 VAL A N   1 
ATOM   3353 C CA  . VAL A 1 612 ? 1.751   80.080  98.016  1.00 64.61  ? 593 VAL A CA  1 
ATOM   3354 C C   . VAL A 1 612 ? 2.770   80.509  99.060  1.00 66.40  ? 593 VAL A C   1 
ATOM   3355 O O   . VAL A 1 612 ? 3.956   80.154  98.962  1.00 67.56  ? 593 VAL A O   1 
ATOM   3356 C CB  . VAL A 1 612 ? 1.628   78.556  97.968  1.00 60.13  ? 593 VAL A CB  1 
ATOM   3357 C CG1 . VAL A 1 612 ? 1.427   78.050  99.342  1.00 62.64  ? 593 VAL A CG1 1 
ATOM   3358 C CG2 . VAL A 1 612 ? 0.455   78.183  97.149  1.00 61.39  ? 593 VAL A CG2 1 
ATOM   3359 N N   . ARG A 1 613 ? 2.308   81.289  100.041 1.00 62.27  ? 594 ARG A N   1 
ATOM   3360 C CA  . ARG A 1 613 ? 3.114   81.749  101.163 1.00 59.65  ? 594 ARG A CA  1 
ATOM   3361 C C   . ARG A 1 613 ? 2.595   81.101  102.442 1.00 65.90  ? 594 ARG A C   1 
ATOM   3362 O O   . ARG A 1 613 ? 1.401   81.194  102.754 1.00 68.60  ? 594 ARG A O   1 
ATOM   3363 C CB  . ARG A 1 613 ? 3.065   83.272  101.284 1.00 72.70  ? 594 ARG A CB  1 
ATOM   3364 C CG  . ARG A 1 613 ? 3.704   84.049  100.126 1.00 74.75  ? 594 ARG A CG  1 
ATOM   3365 C CD  . ARG A 1 613 ? 3.555   85.577  100.277 1.00 72.46  ? 594 ARG A CD  1 
ATOM   3366 N NE  . ARG A 1 613 ? 4.536   86.124  101.203 1.00 76.85  ? 594 ARG A NE  1 
ATOM   3367 C CZ  . ARG A 1 613 ? 5.725   86.613  100.848 1.00 78.45  ? 594 ARG A CZ  1 
ATOM   3368 N NH1 . ARG A 1 613 ? 6.097   86.647  99.564  1.00 68.02  ? 594 ARG A NH1 1 
ATOM   3369 N NH2 . ARG A 1 613 ? 6.546   87.080  101.791 1.00 87.87  ? 594 ARG A NH2 1 
ATOM   3370 N N   . TYR A 1 614 ? 3.481   80.440  103.175 1.00 64.62  ? 595 TYR A N   1 
ATOM   3371 C CA  . TYR A 1 614 ? 3.071   79.672  104.346 1.00 66.06  ? 595 TYR A CA  1 
ATOM   3372 C C   . TYR A 1 614 ? 4.089   79.915  105.450 1.00 71.05  ? 595 TYR A C   1 
ATOM   3373 O O   . TYR A 1 614 ? 5.302   79.791  105.236 1.00 73.76  ? 595 TYR A O   1 
ATOM   3374 C CB  . TYR A 1 614 ? 2.944   78.163  104.024 1.00 73.09  ? 595 TYR A CB  1 
ATOM   3375 C CG  . TYR A 1 614 ? 4.205   77.534  103.453 1.00 66.89  ? 595 TYR A CG  1 
ATOM   3376 C CD1 . TYR A 1 614 ? 4.560   77.724  102.136 1.00 65.72  ? 595 TYR A CD1 1 
ATOM   3377 C CD2 . TYR A 1 614 ? 5.045   76.781  104.243 1.00 64.42  ? 595 TYR A CD2 1 
ATOM   3378 C CE1 . TYR A 1 614 ? 5.705   77.185  101.627 1.00 67.69  ? 595 TYR A CE1 1 
ATOM   3379 C CE2 . TYR A 1 614 ? 6.198   76.238  103.738 1.00 65.36  ? 595 TYR A CE2 1 
ATOM   3380 C CZ  . TYR A 1 614 ? 6.523   76.438  102.428 1.00 65.18  ? 595 TYR A CZ  1 
ATOM   3381 O OH  . TYR A 1 614 ? 7.684   75.905  101.911 1.00 63.72  ? 595 TYR A OH  1 
ATOM   3382 N N   . THR A 1 615 ? 3.599   80.294  106.620 1.00 72.71  ? 596 THR A N   1 
ATOM   3383 C CA  . THR A 1 615 ? 4.451   80.717  107.721 1.00 74.71  ? 596 THR A CA  1 
ATOM   3384 C C   . THR A 1 615 ? 3.997   80.018  108.985 1.00 70.84  ? 596 THR A C   1 
ATOM   3385 O O   . THR A 1 615 ? 2.938   79.382  109.021 1.00 65.58  ? 596 THR A O   1 
ATOM   3386 C CB  . THR A 1 615 ? 4.384   82.232  107.930 1.00 76.26  ? 596 THR A CB  1 
ATOM   3387 O OG1 . THR A 1 615 ? 3.121   82.559  108.531 1.00 76.97  ? 596 THR A OG1 1 
ATOM   3388 C CG2 . THR A 1 615 ? 4.544   82.989  106.589 1.00 73.86  ? 596 THR A CG2 1 
ATOM   3389 N N   . ALA A 1 616 ? 4.800   80.183  110.041 1.00 71.16  ? 597 ALA A N   1 
ATOM   3390 C CA  . ALA A 1 616 ? 4.470   79.558  111.319 1.00 69.17  ? 597 ALA A CA  1 
ATOM   3391 C C   . ALA A 1 616 ? 3.070   79.917  111.784 1.00 62.84  ? 597 ALA A C   1 
ATOM   3392 O O   . ALA A 1 616 ? 2.393   79.101  112.403 1.00 65.38  ? 597 ALA A O   1 
ATOM   3393 C CB  . ALA A 1 616 ? 5.492   79.946  112.375 1.00 68.95  ? 597 ALA A CB  1 
ATOM   3394 N N   . SER A 1 617 ? 2.594   81.097  111.436 1.00 72.53  ? 598 SER A N   1 
ATOM   3395 C CA  . SER A 1 617 ? 1.344   81.617  111.967 1.00 75.39  ? 598 SER A CA  1 
ATOM   3396 C C   . SER A 1 617 ? 0.159   81.408  111.039 1.00 74.91  ? 598 SER A C   1 
ATOM   3397 O O   . SER A 1 617 ? -0.983  81.595  111.473 1.00 75.58  ? 598 SER A O   1 
ATOM   3398 C CB  . SER A 1 617 ? 1.528   83.107  112.291 1.00 79.64  ? 598 SER A CB  1 
ATOM   3399 O OG  . SER A 1 617 ? 2.098   83.774  111.174 1.00 78.43  ? 598 SER A OG  1 
ATOM   3400 N N   . GLY A 1 618 ? 0.399   81.003  109.801 1.00 73.11  ? 599 GLY A N   1 
ATOM   3401 C CA  . GLY A 1 618 ? -0.676  80.773  108.858 1.00 72.80  ? 599 GLY A CA  1 
ATOM   3402 C C   . GLY A 1 618 ? -0.183  80.941  107.429 1.00 73.07  ? 599 GLY A C   1 
ATOM   3403 O O   . GLY A 1 618 ? 1.009   81.145  107.178 1.00 74.08  ? 599 GLY A O   1 
ATOM   3404 N N   . CYS A 1 619 ? -1.129  80.855  106.494 1.00 67.74  ? 600 CYS A N   1 
ATOM   3405 C CA  . CYS A 1 619 ? -0.781  80.908  105.081 1.00 71.48  ? 600 CYS A CA  1 
ATOM   3406 C C   . CYS A 1 619 ? -1.584  81.977  104.383 1.00 69.90  ? 600 CYS A C   1 
ATOM   3407 O O   . CYS A 1 619 ? -2.684  82.342  104.812 1.00 69.40  ? 600 CYS A O   1 
ATOM   3408 C CB  . CYS A 1 619 ? -1.052  79.600  104.338 1.00 66.85  ? 600 CYS A CB  1 
ATOM   3409 S SG  . CYS A 1 619 ? -0.484  78.165  105.176 1.00 78.27  ? 600 CYS A SG  1 
ATOM   3410 N N   . GLU A 1 620 ? -1.020  82.430  103.267 1.00 69.69  ? 601 GLU A N   1 
ATOM   3411 C CA  . GLU A 1 620 ? -1.722  83.280  102.316 1.00 77.29  ? 601 GLU A CA  1 
ATOM   3412 C C   . GLU A 1 620 ? -1.325  82.860  100.912 1.00 72.43  ? 601 GLU A C   1 
ATOM   3413 O O   . GLU A 1 620 ? -0.139  82.643  100.635 1.00 71.50  ? 601 GLU A O   1 
ATOM   3414 C CB  . GLU A 1 620 ? -1.450  84.782  102.569 1.00 86.38  ? 601 GLU A CB  1 
ATOM   3415 C CG  . GLU A 1 620 ? 0.019   85.185  102.798 1.00 90.13  ? 601 GLU A CG  1 
ATOM   3416 C CD  . GLU A 1 620 ? 0.159   86.662  103.196 1.00 107.34 ? 601 GLU A CD  1 
ATOM   3417 O OE1 . GLU A 1 620 ? -0.833  87.431  103.050 1.00 103.25 ? 601 GLU A OE1 1 
ATOM   3418 O OE2 . GLU A 1 620 ? 1.253   87.048  103.685 1.00 114.95 ? 601 GLU A OE2 1 
ATOM   3419 N N   . VAL A 1 621 ? -2.322  82.692  100.050 1.00 68.65  ? 602 VAL A N   1 
ATOM   3420 C CA  . VAL A 1 621 ? -2.100  82.284  98.671  1.00 74.62  ? 602 VAL A CA  1 
ATOM   3421 C C   . VAL A 1 621 ? -2.486  83.457  97.788  1.00 70.58  ? 602 VAL A C   1 
ATOM   3422 O O   . VAL A 1 621 ? -3.487  84.136  98.052  1.00 74.15  ? 602 VAL A O   1 
ATOM   3423 C CB  . VAL A 1 621 ? -2.890  81.003  98.295  1.00 78.87  ? 602 VAL A CB  1 
ATOM   3424 C CG1 . VAL A 1 621 ? -2.677  79.885  99.346  1.00 67.93  ? 602 VAL A CG1 1 
ATOM   3425 C CG2 . VAL A 1 621 ? -4.362  81.277  98.135  1.00 77.67  ? 602 VAL A CG2 1 
ATOM   3426 N N   . ILE A 1 622 ? -1.681  83.714  96.764  1.00 68.58  ? 603 ILE A N   1 
ATOM   3427 C CA  . ILE A 1 622 ? -1.910  84.828  95.847  1.00 71.23  ? 603 ILE A CA  1 
ATOM   3428 C C   . ILE A 1 622 ? -2.406  84.268  94.526  1.00 71.48  ? 603 ILE A C   1 
ATOM   3429 O O   . ILE A 1 622 ? -1.723  83.444  93.902  1.00 73.58  ? 603 ILE A O   1 
ATOM   3430 C CB  . ILE A 1 622 ? -0.644  85.662  95.622  1.00 70.65  ? 603 ILE A CB  1 
ATOM   3431 C CG1 . ILE A 1 622 ? -0.217  86.363  96.903  1.00 77.70  ? 603 ILE A CG1 1 
ATOM   3432 C CG2 . ILE A 1 622 ? -0.919  86.702  94.604  1.00 76.32  ? 603 ILE A CG2 1 
ATOM   3433 C CD1 . ILE A 1 622 ? 0.773   85.602  97.723  1.00 79.82  ? 603 ILE A CD1 1 
ATOM   3434 N N   . ALA A 1 623 ? -3.570  84.737  94.082  1.00 69.33  ? 604 ALA A N   1 
ATOM   3435 C CA  . ALA A 1 623 ? -4.166  84.289  92.832  1.00 73.93  ? 604 ALA A CA  1 
ATOM   3436 C C   . ALA A 1 623 ? -4.513  85.480  91.942  1.00 80.60  ? 604 ALA A C   1 
ATOM   3437 O O   . ALA A 1 623 ? -4.829  86.567  92.438  1.00 79.10  ? 604 ALA A O   1 
ATOM   3438 C CB  . ALA A 1 623 ? -5.419  83.457  93.093  1.00 67.45  ? 604 ALA A CB  1 
ATOM   3439 N N   . VAL A 1 624 ? -4.460  85.264  90.625  1.00 77.15  ? 605 VAL A N   1 
ATOM   3440 C CA  . VAL A 1 624 ? -4.893  86.255  89.652  1.00 73.86  ? 605 VAL A CA  1 
ATOM   3441 C C   . VAL A 1 624 ? -6.193  85.766  89.031  1.00 75.48  ? 605 VAL A C   1 
ATOM   3442 O O   . VAL A 1 624 ? -6.569  84.604  89.164  1.00 78.39  ? 605 VAL A O   1 
ATOM   3443 C CB  . VAL A 1 624 ? -3.851  86.485  88.555  1.00 81.92  ? 605 VAL A CB  1 
ATOM   3444 C CG1 . VAL A 1 624 ? -2.507  86.808  89.164  1.00 83.00  ? 605 VAL A CG1 1 
ATOM   3445 C CG2 . VAL A 1 624 ? -3.820  85.318  87.582  1.00 84.95  ? 605 VAL A CG2 1 
ATOM   3446 N N   . ASN A 1 625 ? -6.877  86.662  88.325  1.00 82.42  ? 606 ASN A N   1 
ATOM   3447 C CA  . ASN A 1 625 ? -8.009  86.282  87.483  1.00 89.89  ? 606 ASN A CA  1 
ATOM   3448 C C   . ASN A 1 625 ? -7.514  85.956  86.072  1.00 88.74  ? 606 ASN A C   1 
ATOM   3449 O O   . ASN A 1 625 ? -6.918  86.808  85.400  1.00 90.30  ? 606 ASN A O   1 
ATOM   3450 C CB  . ASN A 1 625 ? -9.071  87.380  87.444  1.00 93.74  ? 606 ASN A CB  1 
ATOM   3451 C CG  . ASN A 1 625 ? -10.313 86.954  86.683  1.00 91.84  ? 606 ASN A CG  1 
ATOM   3452 O OD1 . ASN A 1 625 ? -11.169 86.227  87.208  1.00 88.66  ? 606 ASN A OD1 1 
ATOM   3453 N ND2 . ASN A 1 625 ? -10.409 87.390  85.432  1.00 90.32  ? 606 ASN A ND2 1 
ATOM   3454 N N   . THR A 1 626 ? -7.780  84.724  85.624  1.00 86.89  ? 607 THR A N   1 
ATOM   3455 C CA  . THR A 1 626 ? -7.206  84.214  84.377  1.00 89.09  ? 607 THR A CA  1 
ATOM   3456 C C   . THR A 1 626 ? -7.545  85.083  83.173  1.00 95.50  ? 607 THR A C   1 
ATOM   3457 O O   . THR A 1 626 ? -6.778  85.128  82.204  1.00 98.18  ? 607 THR A O   1 
ATOM   3458 C CB  . THR A 1 626 ? -7.712  82.806  84.118  1.00 84.13  ? 607 THR A CB  1 
ATOM   3459 O OG1 . THR A 1 626 ? -9.133  82.790  84.295  1.00 87.52  ? 607 THR A OG1 1 
ATOM   3460 C CG2 . THR A 1 626 ? -7.080  81.828  85.076  1.00 81.33  ? 607 THR A CG2 1 
ATOM   3461 N N   . ARG A 1 627 ? -8.688  85.761  83.206  1.00 94.77  ? 608 ARG A N   1 
ATOM   3462 C CA  . ARG A 1 627 ? -9.156  86.497  82.044  1.00 92.74  ? 608 ARG A CA  1 
ATOM   3463 C C   . ARG A 1 627 ? -8.418  87.830  81.890  1.00 104.48 ? 608 ARG A C   1 
ATOM   3464 O O   . ARG A 1 627 ? -7.838  88.110  80.828  1.00 107.77 ? 608 ARG A O   1 
ATOM   3465 C CB  . ARG A 1 627 ? -10.672 86.648  82.160  1.00 91.89  ? 608 ARG A CB  1 
ATOM   3466 C CG  . ARG A 1 627 ? -11.353 85.247  82.250  1.00 90.69  ? 608 ARG A CG  1 
ATOM   3467 C CD  . ARG A 1 627 ? -12.764 85.282  82.827  1.00 89.86  ? 608 ARG A CD  1 
ATOM   3468 N NE  . ARG A 1 627 ? -12.752 85.534  84.266  1.00 96.95  ? 608 ARG A NE  1 
ATOM   3469 C CZ  . ARG A 1 627 ? -13.776 85.299  85.093  1.00 101.28 ? 608 ARG A CZ  1 
ATOM   3470 N NH1 . ARG A 1 627 ? -14.915 84.799  84.624  1.00 100.59 ? 608 ARG A NH1 1 
ATOM   3471 N NH2 . ARG A 1 627 ? -13.659 85.551  86.401  1.00 95.39  ? 608 ARG A NH2 1 
ATOM   3472 N N   . SER A 1 628 ? -8.388  88.642  82.954  1.00 107.02 ? 609 SER A N   1 
ATOM   3473 C CA  . SER A 1 628 ? -7.532  89.832  83.056  1.00 106.65 ? 609 SER A CA  1 
ATOM   3474 C C   . SER A 1 628 ? -6.504  89.572  84.160  1.00 102.11 ? 609 SER A C   1 
ATOM   3475 O O   . SER A 1 628 ? -6.834  89.624  85.352  1.00 94.47  ? 609 SER A O   1 
ATOM   3476 C CB  . SER A 1 628 ? -8.369  91.075  83.345  1.00 105.15 ? 609 SER A CB  1 
ATOM   3477 O OG  . SER A 1 628 ? -9.038  90.949  84.594  1.00 99.82  ? 609 SER A OG  1 
ATOM   3478 N N   . THR A 1 629 ? -5.253  89.293  83.755  1.00 104.86 ? 610 THR A N   1 
ATOM   3479 C CA  . THR A 1 629 ? -4.242  88.789  84.689  1.00 104.41 ? 610 THR A CA  1 
ATOM   3480 C C   . THR A 1 629 ? -3.911  89.791  85.784  1.00 106.27 ? 610 THR A C   1 
ATOM   3481 O O   . THR A 1 629 ? -3.212  89.430  86.738  1.00 105.98 ? 610 THR A O   1 
ATOM   3482 C CB  . THR A 1 629 ? -2.907  88.460  83.994  1.00 107.55 ? 610 THR A CB  1 
ATOM   3483 O OG1 . THR A 1 629 ? -2.230  89.677  83.650  1.00 115.26 ? 610 THR A OG1 1 
ATOM   3484 C CG2 . THR A 1 629 ? -3.161  87.675  82.717  1.00 102.68 ? 610 THR A CG2 1 
ATOM   3485 N N   . SER A 1 630 ? -4.364  91.038  85.654  1.00 104.32 ? 611 SER A N   1 
ATOM   3486 C CA  . SER A 1 630 ? -3.952  92.082  86.582  1.00 96.78  ? 611 SER A CA  1 
ATOM   3487 C C   . SER A 1 630 ? -4.757  92.051  87.872  1.00 97.25  ? 611 SER A C   1 
ATOM   3488 O O   . SER A 1 630 ? -4.186  92.209  88.955  1.00 102.25 ? 611 SER A O   1 
ATOM   3489 C CB  . SER A 1 630 ? -4.067  93.436  85.909  1.00 94.86  ? 611 SER A CB  1 
ATOM   3490 O OG  . SER A 1 630 ? -3.503  93.336  84.614  1.00 117.65 ? 611 SER A OG  1 
ATOM   3491 N N   . GLN A 1 631 ? -6.069  91.845  87.782  1.00 90.50  ? 612 GLN A N   1 
ATOM   3492 C CA  . GLN A 1 631 ? -6.914  91.680  88.960  1.00 87.61  ? 612 GLN A CA  1 
ATOM   3493 C C   . GLN A 1 631 ? -6.353  90.633  89.920  1.00 88.70  ? 612 GLN A C   1 
ATOM   3494 O O   . GLN A 1 631 ? -6.271  89.451  89.582  1.00 91.81  ? 612 GLN A O   1 
ATOM   3495 C CB  . GLN A 1 631 ? -8.301  91.274  88.504  1.00 91.63  ? 612 GLN A CB  1 
ATOM   3496 C CG  . GLN A 1 631 ? -9.318  91.272  89.600  1.00 99.93  ? 612 GLN A CG  1 
ATOM   3497 C CD  . GLN A 1 631 ? -10.709 91.226  89.021  1.00 112.44 ? 612 GLN A CD  1 
ATOM   3498 O OE1 . GLN A 1 631 ? -10.870 91.201  87.792  1.00 103.99 ? 612 GLN A OE1 1 
ATOM   3499 N NE2 . GLN A 1 631 ? -11.727 91.213  89.889  1.00 116.40 ? 612 GLN A NE2 1 
ATOM   3500 N N   . THR A 1 632 ? -5.990  91.052  91.132  1.00 88.61  ? 613 THR A N   1 
ATOM   3501 C CA  . THR A 1 632 ? -5.186  90.228  92.032  1.00 82.41  ? 613 THR A CA  1 
ATOM   3502 C C   . THR A 1 632 ? -5.938  89.899  93.322  1.00 79.66  ? 613 THR A C   1 
ATOM   3503 O O   . THR A 1 632 ? -6.646  90.751  93.875  1.00 85.71  ? 613 THR A O   1 
ATOM   3504 C CB  . THR A 1 632 ? -3.868  90.937  92.340  1.00 73.54  ? 613 THR A CB  1 
ATOM   3505 O OG1 . THR A 1 632 ? -3.041  90.911  91.168  1.00 80.94  ? 613 THR A OG1 1 
ATOM   3506 C CG2 . THR A 1 632 ? -3.148  90.261  93.467  1.00 69.95  ? 613 THR A CG2 1 
ATOM   3507 N N   . PHE A 1 633 ? -5.789  88.659  93.803  1.00 74.64  ? 614 PHE A N   1 
ATOM   3508 C CA  . PHE A 1 633 ? -6.496  88.190  94.991  1.00 76.87  ? 614 PHE A CA  1 
ATOM   3509 C C   . PHE A 1 633 ? -5.545  87.640  96.058  1.00 72.66  ? 614 PHE A C   1 
ATOM   3510 O O   . PHE A 1 633 ? -4.555  86.960  95.754  1.00 71.09  ? 614 PHE A O   1 
ATOM   3511 C CB  . PHE A 1 633 ? -7.497  87.107  94.637  1.00 78.24  ? 614 PHE A CB  1 
ATOM   3512 C CG  . PHE A 1 633 ? -8.605  87.564  93.750  1.00 85.30  ? 614 PHE A CG  1 
ATOM   3513 C CD1 . PHE A 1 633 ? -8.419  87.653  92.375  1.00 89.24  ? 614 PHE A CD1 1 
ATOM   3514 C CD2 . PHE A 1 633 ? -9.847  87.884  94.287  1.00 87.51  ? 614 PHE A CD2 1 
ATOM   3515 C CE1 . PHE A 1 633 ? -9.451  88.064  91.545  1.00 93.88  ? 614 PHE A CE1 1 
ATOM   3516 C CE2 . PHE A 1 633 ? -10.889 88.293  93.471  1.00 93.84  ? 614 PHE A CE2 1 
ATOM   3517 C CZ  . PHE A 1 633 ? -10.693 88.385  92.097  1.00 100.63 ? 614 PHE A CZ  1 
ATOM   3518 N N   . ILE A 1 634 ? -5.866  87.923  97.313  1.00 66.35  ? 615 ILE A N   1 
ATOM   3519 C CA  . ILE A 1 634 ? -5.132  87.415  98.464  1.00 73.15  ? 615 ILE A CA  1 
ATOM   3520 C C   . ILE A 1 634 ? -6.096  86.591  99.305  1.00 75.38  ? 615 ILE A C   1 
ATOM   3521 O O   . ILE A 1 634 ? -7.205  87.056  99.612  1.00 79.42  ? 615 ILE A O   1 
ATOM   3522 C CB  . ILE A 1 634 ? -4.559  88.557  99.313  1.00 74.51  ? 615 ILE A CB  1 
ATOM   3523 C CG1 . ILE A 1 634 ? -3.443  89.312  98.592  1.00 69.91  ? 615 ILE A CG1 1 
ATOM   3524 C CG2 . ILE A 1 634 ? -4.048  87.989  100.595 1.00 77.52  ? 615 ILE A CG2 1 
ATOM   3525 C CD1 . ILE A 1 634 ? -2.191  88.547  98.483  1.00 77.40  ? 615 ILE A CD1 1 
ATOM   3526 N N   . TYR A 1 635 ? -5.681  85.375  99.681  1.00 73.88  ? 616 TYR A N   1 
ATOM   3527 C CA  . TYR A 1 635 ? -6.481  84.490  100.531 1.00 73.77  ? 616 TYR A CA  1 
ATOM   3528 C C   . TYR A 1 635 ? -5.660  84.083  101.743 1.00 72.84  ? 616 TYR A C   1 
ATOM   3529 O O   . TYR A 1 635 ? -4.536  83.597  101.586 1.00 70.40  ? 616 TYR A O   1 
ATOM   3530 C CB  . TYR A 1 635 ? -6.929  83.243  99.773  1.00 69.58  ? 616 TYR A CB  1 
ATOM   3531 C CG  . TYR A 1 635 ? -7.883  83.536  98.632  1.00 76.80  ? 616 TYR A CG  1 
ATOM   3532 C CD1 . TYR A 1 635 ? -9.261  83.517  98.836  1.00 71.01  ? 616 TYR A CD1 1 
ATOM   3533 C CD2 . TYR A 1 635 ? -7.407  83.841  97.343  1.00 74.36  ? 616 TYR A CD2 1 
ATOM   3534 C CE1 . TYR A 1 635 ? -10.142 83.780  97.809  1.00 69.63  ? 616 TYR A CE1 1 
ATOM   3535 C CE2 . TYR A 1 635 ? -8.287  84.108  96.298  1.00 68.87  ? 616 TYR A CE2 1 
ATOM   3536 C CZ  . TYR A 1 635 ? -9.659  84.079  96.547  1.00 75.17  ? 616 TYR A CZ  1 
ATOM   3537 O OH  . TYR A 1 635 ? -10.570 84.353  95.549  1.00 85.61  ? 616 TYR A OH  1 
ATOM   3538 N N   . LYS A 1 636 ? -6.208  84.285  102.939 1.00 69.31  ? 617 LYS A N   1 
ATOM   3539 C CA  . LYS A 1 636 ? -5.546  83.858  104.163 1.00 69.77  ? 617 LYS A CA  1 
ATOM   3540 C C   . LYS A 1 636 ? -6.193  82.568  104.646 1.00 73.00  ? 617 LYS A C   1 
ATOM   3541 O O   . LYS A 1 636 ? -7.390  82.344  104.446 1.00 83.08  ? 617 LYS A O   1 
ATOM   3542 C CB  . LYS A 1 636 ? -5.640  84.915  105.271 1.00 82.68  ? 617 LYS A CB  1 
ATOM   3543 C CG  . LYS A 1 636 ? -5.488  86.375  104.826 1.00 91.83  ? 617 LYS A CG  1 
ATOM   3544 C CD  . LYS A 1 636 ? -4.047  86.951  104.828 1.00 93.23  ? 617 LYS A CD  1 
ATOM   3545 C CE  . LYS A 1 636 ? -4.079  88.410  104.258 1.00 94.21  ? 617 LYS A CE  1 
ATOM   3546 N NZ  . LYS A 1 636 ? -2.829  89.218  104.337 1.00 87.87  ? 617 LYS A NZ  1 
ATOM   3547 N N   . CYS A 1 637 ? -5.400  81.719  105.292 1.00 69.67  ? 618 CYS A N   1 
ATOM   3548 C CA  . CYS A 1 637 ? -5.939  80.437  105.734 1.00 71.23  ? 618 CYS A CA  1 
ATOM   3549 C C   . CYS A 1 637 ? -4.973  79.783  106.715 1.00 69.02  ? 618 CYS A C   1 
ATOM   3550 O O   . CYS A 1 637 ? -3.776  80.099  106.748 1.00 63.69  ? 618 CYS A O   1 
ATOM   3551 C CB  . CYS A 1 637 ? -6.171  79.514  104.540 1.00 77.71  ? 618 CYS A CB  1 
ATOM   3552 S SG  . CYS A 1 637 ? -4.586  79.154  103.680 1.00 75.92  ? 618 CYS A SG  1 
ATOM   3553 N N   . ASP A 1 638 ? -5.507  78.829  107.483 1.00 69.71  ? 619 ASP A N   1 
ATOM   3554 C CA  . ASP A 1 638 ? -4.672  78.053  108.399 1.00 74.25  ? 619 ASP A CA  1 
ATOM   3555 C C   . ASP A 1 638 ? -3.828  76.998  107.692 1.00 73.73  ? 619 ASP A C   1 
ATOM   3556 O O   . ASP A 1 638 ? -2.730  76.673  108.164 1.00 69.53  ? 619 ASP A O   1 
ATOM   3557 C CB  . ASP A 1 638 ? -5.531  77.380  109.462 1.00 72.49  ? 619 ASP A CB  1 
ATOM   3558 C CG  . ASP A 1 638 ? -6.354  78.366  110.227 1.00 79.34  ? 619 ASP A CG  1 
ATOM   3559 O OD1 . ASP A 1 638 ? -5.753  79.129  111.036 1.00 82.98  ? 619 ASP A OD1 1 
ATOM   3560 O OD2 . ASP A 1 638 ? -7.590  78.372  109.994 1.00 75.36  ? 619 ASP A OD2 1 
ATOM   3561 N N   . ALA A 1 639 ? -4.313  76.443  106.581 1.00 78.34  ? 620 ALA A N   1 
ATOM   3562 C CA  . ALA A 1 639 ? -3.541  75.464  105.827 1.00 70.76  ? 620 ALA A CA  1 
ATOM   3563 C C   . ALA A 1 639 ? -3.976  75.469  104.373 1.00 70.16  ? 620 ALA A C   1 
ATOM   3564 O O   . ALA A 1 639 ? -5.143  75.729  104.056 1.00 72.50  ? 620 ALA A O   1 
ATOM   3565 C CB  . ALA A 1 639 ? -3.694  74.052  106.392 1.00 68.94  ? 620 ALA A CB  1 
ATOM   3566 N N   . VAL A 1 640 ? -3.019  75.157  103.500 1.00 67.52  ? 621 VAL A N   1 
ATOM   3567 C CA  . VAL A 1 640 ? -3.256  75.005  102.066 1.00 67.73  ? 621 VAL A CA  1 
ATOM   3568 C C   . VAL A 1 640 ? -3.182  73.525  101.689 1.00 66.28  ? 621 VAL A C   1 
ATOM   3569 O O   . VAL A 1 640 ? -2.209  72.831  102.017 1.00 66.24  ? 621 VAL A O   1 
ATOM   3570 C CB  . VAL A 1 640 ? -2.237  75.806  101.248 1.00 63.02  ? 621 VAL A CB  1 
ATOM   3571 C CG1 . VAL A 1 640 ? -2.689  75.882  99.828  1.00 65.30  ? 621 VAL A CG1 1 
ATOM   3572 C CG2 . VAL A 1 640 ? -2.060  77.163  101.828 1.00 66.92  ? 621 VAL A CG2 1 
ATOM   3573 N N   . LEU A 1 641 ? -4.188  73.043  100.987 1.00 62.09  ? 622 LEU A N   1 
ATOM   3574 C CA  . LEU A 1 641 ? -4.107  71.730  100.372 1.00 61.46  ? 622 LEU A CA  1 
ATOM   3575 C C   . LEU A 1 641 ? -3.801  71.907  98.894  1.00 60.70  ? 622 LEU A C   1 
ATOM   3576 O O   . LEU A 1 641 ? -4.574  72.531  98.157  1.00 62.93  ? 622 LEU A O   1 
ATOM   3577 C CB  . LEU A 1 641 ? -5.396  70.952  100.568 1.00 63.10  ? 622 LEU A CB  1 
ATOM   3578 C CG  . LEU A 1 641 ? -5.280  69.626  99.857  1.00 59.36  ? 622 LEU A CG  1 
ATOM   3579 C CD1 . LEU A 1 641 ? -4.199  68.759  100.473 1.00 57.58  ? 622 LEU A CD1 1 
ATOM   3580 C CD2 . LEU A 1 641 ? -6.604  68.986  100.003 1.00 61.59  ? 622 LEU A CD2 1 
ATOM   3581 N N   . CYS A 1 642 ? -2.682  71.371  98.464  1.00 61.68  ? 623 CYS A N   1 
ATOM   3582 C CA  . CYS A 1 642 ? -2.224  71.537  97.093  1.00 64.29  ? 623 CYS A CA  1 
ATOM   3583 C C   . CYS A 1 642 ? -2.550  70.284  96.265  1.00 61.58  ? 623 CYS A C   1 
ATOM   3584 O O   . CYS A 1 642 ? -1.993  69.208  96.505  1.00 65.52  ? 623 CYS A O   1 
ATOM   3585 C CB  . CYS A 1 642 ? -0.733  71.834  97.109  1.00 61.32  ? 623 CYS A CB  1 
ATOM   3586 S SG  . CYS A 1 642 ? -0.050  71.931  95.497  1.00 75.43  ? 623 CYS A SG  1 
ATOM   3587 N N   . THR A 1 643 ? -3.469  70.411  95.309  1.00 55.39  ? 624 THR A N   1 
ATOM   3588 C CA  . THR A 1 643 ? -3.723  69.342  94.361  1.00 60.33  ? 624 THR A CA  1 
ATOM   3589 C C   . THR A 1 643 ? -3.254  69.747  92.970  1.00 61.86  ? 624 THR A C   1 
ATOM   3590 O O   . THR A 1 643 ? -3.770  69.266  91.961  1.00 67.61  ? 624 THR A O   1 
ATOM   3591 C CB  . THR A 1 643 ? -5.194  68.913  94.366  1.00 60.28  ? 624 THR A CB  1 
ATOM   3592 O OG1 . THR A 1 643 ? -6.016  69.795  93.592  1.00 58.54  ? 624 THR A OG1 1 
ATOM   3593 C CG2 . THR A 1 643 ? -5.690  68.935  95.761  1.00 61.58  ? 624 THR A CG2 1 
ATOM   3594 N N   . LEU A 1 644 ? -2.258  70.612  92.910  1.00 58.71  ? 625 LEU A N   1 
ATOM   3595 C CA  . LEU A 1 644 ? -1.672  70.963  91.629  1.00 59.42  ? 625 LEU A CA  1 
ATOM   3596 C C   . LEU A 1 644 ? -1.144  69.708  90.954  1.00 62.13  ? 625 LEU A C   1 
ATOM   3597 O O   . LEU A 1 644 ? -0.438  68.922  91.596  1.00 66.23  ? 625 LEU A O   1 
ATOM   3598 C CB  . LEU A 1 644 ? -0.535  71.959  91.807  1.00 60.40  ? 625 LEU A CB  1 
ATOM   3599 C CG  . LEU A 1 644 ? -0.976  73.394  92.031  1.00 60.78  ? 625 LEU A CG  1 
ATOM   3600 C CD1 . LEU A 1 644 ? 0.217   74.238  92.344  1.00 64.34  ? 625 LEU A CD1 1 
ATOM   3601 C CD2 . LEU A 1 644 ? -1.678  73.901  90.816  1.00 58.02  ? 625 LEU A CD2 1 
ATOM   3602 N N   . PRO A 1 645 ? -1.475  69.475  89.689  1.00 62.01  ? 626 PRO A N   1 
ATOM   3603 C CA  . PRO A 1 645 ? -0.940  68.318  88.974  1.00 65.65  ? 626 PRO A CA  1 
ATOM   3604 C C   . PRO A 1 645 ? 0.572   68.282  89.043  1.00 67.83  ? 626 PRO A C   1 
ATOM   3605 O O   . PRO A 1 645 ? 1.226   69.320  89.203  1.00 63.28  ? 626 PRO A O   1 
ATOM   3606 C CB  . PRO A 1 645 ? -1.421  68.548  87.542  1.00 59.84  ? 626 PRO A CB  1 
ATOM   3607 C CG  . PRO A 1 645 ? -2.721  69.191  87.737  1.00 62.69  ? 626 PRO A CG  1 
ATOM   3608 C CD  . PRO A 1 645 ? -2.507  70.156  88.899  1.00 65.14  ? 626 PRO A CD  1 
ATOM   3609 N N   . LEU A 1 646 ? 1.124   67.060  88.934  1.00 64.46  ? 627 LEU A N   1 
ATOM   3610 C CA  . LEU A 1 646 ? 2.575   66.934  89.020  1.00 62.18  ? 627 LEU A CA  1 
ATOM   3611 C C   . LEU A 1 646 ? 3.267   67.679  87.880  1.00 68.38  ? 627 LEU A C   1 
ATOM   3612 O O   . LEU A 1 646 ? 4.381   68.189  88.054  1.00 70.27  ? 627 LEU A O   1 
ATOM   3613 C CB  . LEU A 1 646 ? 2.976   65.471  89.039  1.00 58.61  ? 627 LEU A CB  1 
ATOM   3614 C CG  . LEU A 1 646 ? 4.471   65.177  88.868  1.00 59.41  ? 627 LEU A CG  1 
ATOM   3615 C CD1 . LEU A 1 646 ? 5.361   65.937  89.816  1.00 59.47  ? 627 LEU A CD1 1 
ATOM   3616 C CD2 . LEU A 1 646 ? 4.751   63.688  89.026  1.00 65.85  ? 627 LEU A CD2 1 
ATOM   3617 N N   . GLY A 1 647 ? 2.612   67.792  86.722  1.00 67.92  ? 628 GLY A N   1 
ATOM   3618 C CA  . GLY A 1 647 ? 3.222   68.514  85.620  1.00 62.85  ? 628 GLY A CA  1 
ATOM   3619 C C   . GLY A 1 647 ? 3.308   69.995  85.891  1.00 67.58  ? 628 GLY A C   1 
ATOM   3620 O O   . GLY A 1 647 ? 4.314   70.638  85.573  1.00 69.11  ? 628 GLY A O   1 
ATOM   3621 N N   . VAL A 1 648 ? 2.250   70.555  86.482  1.00 71.54  ? 629 VAL A N   1 
ATOM   3622 C CA  . VAL A 1 648 ? 2.292   71.945  86.924  1.00 65.91  ? 629 VAL A CA  1 
ATOM   3623 C C   . VAL A 1 648 ? 3.432   72.139  87.903  1.00 65.93  ? 629 VAL A C   1 
ATOM   3624 O O   . VAL A 1 648 ? 4.218   73.086  87.781  1.00 70.07  ? 629 VAL A O   1 
ATOM   3625 C CB  . VAL A 1 648 ? 0.947   72.350  87.542  1.00 58.85  ? 629 VAL A CB  1 
ATOM   3626 C CG1 . VAL A 1 648 ? 1.108   73.646  88.300  1.00 60.46  ? 629 VAL A CG1 1 
ATOM   3627 C CG2 . VAL A 1 648 ? -0.122  72.457  86.445  1.00 58.73  ? 629 VAL A CG2 1 
ATOM   3628 N N   . LEU A 1 649 ? 3.557   71.226  88.875  1.00 59.81  ? 630 LEU A N   1 
ATOM   3629 C CA  . LEU A 1 649 ? 4.613   71.351  89.869  1.00 61.21  ? 630 LEU A CA  1 
ATOM   3630 C C   . LEU A 1 649 ? 5.986   71.219  89.258  1.00 67.82  ? 630 LEU A C   1 
ATOM   3631 O O   . LEU A 1 649 ? 6.961   71.690  89.850  1.00 70.25  ? 630 LEU A O   1 
ATOM   3632 C CB  . LEU A 1 649 ? 4.495   70.291  90.951  1.00 68.55  ? 630 LEU A CB  1 
ATOM   3633 C CG  . LEU A 1 649 ? 3.354   70.365  91.951  1.00 68.48  ? 630 LEU A CG  1 
ATOM   3634 C CD1 . LEU A 1 649 ? 3.586   69.318  93.019  1.00 56.05  ? 630 LEU A CD1 1 
ATOM   3635 C CD2 . LEU A 1 649 ? 3.271   71.767  92.519  1.00 57.83  ? 630 LEU A CD2 1 
ATOM   3636 N N   . LYS A 1 650 ? 6.093   70.550  88.109  1.00 71.34  ? 631 LYS A N   1 
ATOM   3637 C CA  . LYS A 1 650 ? 7.392   70.349  87.489  1.00 65.74  ? 631 LYS A CA  1 
ATOM   3638 C C   . LYS A 1 650 ? 7.832   71.556  86.690  1.00 72.33  ? 631 LYS A C   1 
ATOM   3639 O O   . LYS A 1 650 ? 9.022   71.676  86.386  1.00 80.00  ? 631 LYS A O   1 
ATOM   3640 C CB  . LYS A 1 650 ? 7.352   69.135  86.577  1.00 63.36  ? 631 LYS A CB  1 
ATOM   3641 C CG  . LYS A 1 650 ? 7.474   67.786  87.249  1.00 66.33  ? 631 LYS A CG  1 
ATOM   3642 C CD  . LYS A 1 650 ? 7.138   66.661  86.270  1.00 54.50  ? 631 LYS A CD  1 
ATOM   3643 C CE  . LYS A 1 650 ? 7.902   65.409  86.595  1.00 58.64  ? 631 LYS A CE  1 
ATOM   3644 N NZ  . LYS A 1 650 ? 9.359   65.670  86.710  1.00 60.84  ? 631 LYS A NZ  1 
ATOM   3645 N N   . GLN A 1 651 ? 6.900   72.453  86.379  1.00 69.91  ? 632 GLN A N   1 
ATOM   3646 C CA  . GLN A 1 651 ? 7.113   73.507  85.397  1.00 72.91  ? 632 GLN A CA  1 
ATOM   3647 C C   . GLN A 1 651 ? 8.267   74.419  85.795  1.00 83.29  ? 632 GLN A C   1 
ATOM   3648 O O   . GLN A 1 651 ? 8.246   75.043  86.860  1.00 86.95  ? 632 GLN A O   1 
ATOM   3649 C CB  . GLN A 1 651 ? 5.817   74.294  85.239  1.00 70.80  ? 632 GLN A CB  1 
ATOM   3650 C CG  . GLN A 1 651 ? 5.863   75.437  84.280  1.00 82.43  ? 632 GLN A CG  1 
ATOM   3651 C CD  . GLN A 1 651 ? 4.480   76.079  84.051  1.00 88.85  ? 632 GLN A CD  1 
ATOM   3652 O OE1 . GLN A 1 651 ? 3.438   75.549  84.472  1.00 83.21  ? 632 GLN A OE1 1 
ATOM   3653 N NE2 . GLN A 1 651 ? 4.469   77.228  83.358  1.00 90.87  ? 632 GLN A NE2 1 
ATOM   3654 N N   . GLN A 1 652 ? 9.308   74.456  84.958  1.00 92.70  ? 633 GLN A N   1 
ATOM   3655 C CA  . GLN A 1 652 ? 10.313  75.520  85.033  1.00 94.65  ? 633 GLN A CA  1 
ATOM   3656 C C   . GLN A 1 652 ? 10.209  76.402  83.802  1.00 103.60 ? 633 GLN A C   1 
ATOM   3657 O O   . GLN A 1 652 ? 10.197  75.886  82.671  1.00 102.59 ? 633 GLN A O   1 
ATOM   3658 C CB  . GLN A 1 652 ? 11.739  74.968  85.153  1.00 94.46  ? 633 GLN A CB  1 
ATOM   3659 C CG  . GLN A 1 652 ? 11.980  74.151  86.390  1.00 98.47  ? 633 GLN A CG  1 
ATOM   3660 C CD  . GLN A 1 652 ? 11.622  74.915  87.675  1.00 105.94 ? 633 GLN A CD  1 
ATOM   3661 O OE1 . GLN A 1 652 ? 10.716  74.487  88.410  1.00 103.64 ? 633 GLN A OE1 1 
ATOM   3662 N NE2 . GLN A 1 652 ? 12.301  76.042  87.937  1.00 95.25  ? 633 GLN A NE2 1 
ATOM   3663 N N   . PRO A 1 653 ? 10.106  77.729  83.988  1.00 101.68 ? 634 PRO A N   1 
ATOM   3664 C CA  . PRO A 1 653 ? 10.140  78.358  85.319  1.00 95.01  ? 634 PRO A CA  1 
ATOM   3665 C C   . PRO A 1 653 ? 8.773   78.272  86.011  1.00 91.85  ? 634 PRO A C   1 
ATOM   3666 O O   . PRO A 1 653 ? 7.760   78.142  85.316  1.00 92.69  ? 634 PRO A O   1 
ATOM   3667 C CB  . PRO A 1 653 ? 10.519  79.809  85.023  1.00 91.13  ? 634 PRO A CB  1 
ATOM   3668 C CG  . PRO A 1 653 ? 10.423  79.971  83.517  1.00 99.61  ? 634 PRO A CG  1 
ATOM   3669 C CD  . PRO A 1 653 ? 9.853   78.718  82.939  1.00 99.72  ? 634 PRO A CD  1 
ATOM   3670 N N   . PRO A 1 654 ? 8.760   78.353  87.339  1.00 80.41  ? 635 PRO A N   1 
ATOM   3671 C CA  . PRO A 1 654 ? 7.573   77.945  88.104  1.00 81.03  ? 635 PRO A CA  1 
ATOM   3672 C C   . PRO A 1 654 ? 6.308   78.707  87.738  1.00 75.28  ? 635 PRO A C   1 
ATOM   3673 O O   . PRO A 1 654 ? 6.297   79.931  87.720  1.00 77.68  ? 635 PRO A O   1 
ATOM   3674 C CB  . PRO A 1 654 ? 7.995   78.221  89.548  1.00 78.05  ? 635 PRO A CB  1 
ATOM   3675 C CG  . PRO A 1 654 ? 9.465   77.944  89.520  1.00 86.13  ? 635 PRO A CG  1 
ATOM   3676 C CD  . PRO A 1 654 ? 9.939   78.500  88.202  1.00 82.77  ? 635 PRO A CD  1 
ATOM   3677 N N   . ALA A 1 655 ? 5.225   77.963  87.466  1.00 69.51  ? 636 ALA A N   1 
ATOM   3678 C CA  . ALA A 1 655 ? 3.903   78.565  87.320  1.00 60.09  ? 636 ALA A CA  1 
ATOM   3679 C C   . ALA A 1 655 ? 3.347   79.065  88.640  1.00 68.98  ? 636 ALA A C   1 
ATOM   3680 O O   . ALA A 1 655 ? 2.445   79.915  88.637  1.00 70.97  ? 636 ALA A O   1 
ATOM   3681 C CB  . ALA A 1 655 ? 2.910   77.560  86.759  1.00 70.15  ? 636 ALA A CB  1 
ATOM   3682 N N   . VAL A 1 656 ? 3.829   78.504  89.754  1.00 69.94  ? 637 VAL A N   1 
ATOM   3683 C CA  . VAL A 1 656 ? 3.395   78.787  91.119  1.00 62.98  ? 637 VAL A CA  1 
ATOM   3684 C C   . VAL A 1 656 ? 4.653   78.799  91.960  1.00 63.91  ? 637 VAL A C   1 
ATOM   3685 O O   . VAL A 1 656 ? 5.339   77.775  92.058  1.00 65.40  ? 637 VAL A O   1 
ATOM   3686 C CB  . VAL A 1 656 ? 2.438   77.725  91.696  1.00 58.60  ? 637 VAL A CB  1 
ATOM   3687 C CG1 . VAL A 1 656 ? 2.078   78.090  93.110  1.00 64.48  ? 637 VAL A CG1 1 
ATOM   3688 C CG2 . VAL A 1 656 ? 1.201   77.589  90.897  1.00 58.93  ? 637 VAL A CG2 1 
ATOM   3689 N N   . GLN A 1 657 ? 4.953   79.919  92.596  1.00 62.42  ? 638 GLN A N   1 
ATOM   3690 C CA  . GLN A 1 657 ? 6.119   79.870  93.458  1.00 70.57  ? 638 GLN A CA  1 
ATOM   3691 C C   . GLN A 1 657 ? 5.697   79.726  94.910  1.00 71.62  ? 638 GLN A C   1 
ATOM   3692 O O   . GLN A 1 657 ? 4.667   80.255  95.348  1.00 68.79  ? 638 GLN A O   1 
ATOM   3693 C CB  . GLN A 1 657 ? 7.044   81.076  93.294  1.00 73.39  ? 638 GLN A CB  1 
ATOM   3694 C CG  . GLN A 1 657 ? 6.560   82.404  93.797  1.00 81.91  ? 638 GLN A CG  1 
ATOM   3695 C CD  . GLN A 1 657 ? 7.753   83.316  94.124  1.00 92.78  ? 638 GLN A CD  1 
ATOM   3696 O OE1 . GLN A 1 657 ? 8.882   82.835  94.304  1.00 84.27  ? 638 GLN A OE1 1 
ATOM   3697 N NE2 . GLN A 1 657 ? 7.517   84.630  94.155  1.00 99.99  ? 638 GLN A NE2 1 
ATOM   3698 N N   . PHE A 1 658 ? 6.490   78.952  95.640  1.00 67.50  ? 639 PHE A N   1 
ATOM   3699 C CA  . PHE A 1 658 ? 6.239   78.703  97.043  1.00 65.21  ? 639 PHE A CA  1 
ATOM   3700 C C   . PHE A 1 658 ? 7.186   79.556  97.874  1.00 69.74  ? 639 PHE A C   1 
ATOM   3701 O O   . PHE A 1 658 ? 8.384   79.681  97.557  1.00 65.63  ? 639 PHE A O   1 
ATOM   3702 C CB  . PHE A 1 658 ? 6.420   77.226  97.375  1.00 68.37  ? 639 PHE A CB  1 
ATOM   3703 C CG  . PHE A 1 658 ? 5.353   76.328  96.799  1.00 66.35  ? 639 PHE A CG  1 
ATOM   3704 C CD1 . PHE A 1 658 ? 4.241   75.974  97.551  1.00 66.18  ? 639 PHE A CD1 1 
ATOM   3705 C CD2 . PHE A 1 658 ? 5.484   75.812  95.526  1.00 65.43  ? 639 PHE A CD2 1 
ATOM   3706 C CE1 . PHE A 1 658 ? 3.284   75.138  97.047  1.00 61.09  ? 639 PHE A CE1 1 
ATOM   3707 C CE2 . PHE A 1 658 ? 4.524   74.992  95.000  1.00 60.29  ? 639 PHE A CE2 1 
ATOM   3708 C CZ  . PHE A 1 658 ? 3.420   74.656  95.759  1.00 63.74  ? 639 PHE A CZ  1 
ATOM   3709 N N   . VAL A 1 659 ? 6.628   80.160  98.923  1.00 64.88  ? 640 VAL A N   1 
ATOM   3710 C CA  . VAL A 1 659 ? 7.344   81.101  99.777  1.00 62.29  ? 640 VAL A CA  1 
ATOM   3711 C C   . VAL A 1 659 ? 7.112   80.710  101.230 1.00 66.22  ? 640 VAL A C   1 
ATOM   3712 O O   . VAL A 1 659 ? 6.051   81.016  101.807 1.00 66.76  ? 640 VAL A O   1 
ATOM   3713 C CB  . VAL A 1 659 ? 6.907   82.546  99.502  1.00 66.89  ? 640 VAL A CB  1 
ATOM   3714 C CG1 . VAL A 1 659 ? 7.664   83.502  100.386 1.00 67.61  ? 640 VAL A CG1 1 
ATOM   3715 C CG2 . VAL A 1 659 ? 7.137   82.897  98.039  1.00 71.04  ? 640 VAL A CG2 1 
ATOM   3716 N N   . PRO A 1 660 ? 8.086   80.053  101.872 1.00 66.26  ? 641 PRO A N   1 
ATOM   3717 C CA  . PRO A 1 660 ? 9.424   79.740  101.346 1.00 60.31  ? 641 PRO A CA  1 
ATOM   3718 C C   . PRO A 1 660 ? 9.423   78.599  100.318 1.00 63.96  ? 641 PRO A C   1 
ATOM   3719 O O   . PRO A 1 660 ? 8.429   77.867  100.201 1.00 63.27  ? 641 PRO A O   1 
ATOM   3720 C CB  . PRO A 1 660 ? 10.185  79.337  102.604 1.00 57.19  ? 641 PRO A CB  1 
ATOM   3721 C CG  . PRO A 1 660 ? 9.150   78.744  103.466 1.00 60.00  ? 641 PRO A CG  1 
ATOM   3722 C CD  . PRO A 1 660 ? 7.881   79.493  103.220 1.00 63.45  ? 641 PRO A CD  1 
ATOM   3723 N N   . PRO A 1 661 ? 10.521  78.435  99.582  1.00 60.98  ? 642 PRO A N   1 
ATOM   3724 C CA  . PRO A 1 661 ? 10.569  77.363  98.592  1.00 59.61  ? 642 PRO A CA  1 
ATOM   3725 C C   . PRO A 1 661 ? 10.357  76.016  99.263  1.00 63.22  ? 642 PRO A C   1 
ATOM   3726 O O   . PRO A 1 661 ? 10.647  75.837  100.451 1.00 63.56  ? 642 PRO A O   1 
ATOM   3727 C CB  . PRO A 1 661 ? 11.988  77.468  98.020  1.00 56.25  ? 642 PRO A CB  1 
ATOM   3728 C CG  . PRO A 1 661 ? 12.524  78.703  98.516  1.00 53.14  ? 642 PRO A CG  1 
ATOM   3729 C CD  . PRO A 1 661 ? 11.863  78.975  99.812  1.00 57.38  ? 642 PRO A CD  1 
ATOM   3730 N N   . LEU A 1 662 ? 9.850   75.065  98.482  1.00 66.91  ? 643 LEU A N   1 
ATOM   3731 C CA  . LEU A 1 662 ? 9.719   73.699  98.969  1.00 59.24  ? 643 LEU A CA  1 
ATOM   3732 C C   . LEU A 1 662 ? 11.101  73.141  99.286  1.00 56.96  ? 643 LEU A C   1 
ATOM   3733 O O   . LEU A 1 662 ? 12.083  73.501  98.629  1.00 58.69  ? 643 LEU A O   1 
ATOM   3734 C CB  . LEU A 1 662 ? 9.008   72.835  97.933  1.00 57.22  ? 643 LEU A CB  1 
ATOM   3735 C CG  . LEU A 1 662 ? 7.610   73.433  97.728  1.00 62.05  ? 643 LEU A CG  1 
ATOM   3736 C CD1 . LEU A 1 662 ? 6.897   72.876  96.540  1.00 54.91  ? 643 LEU A CD1 1 
ATOM   3737 C CD2 . LEU A 1 662 ? 6.792   73.206  98.966  1.00 65.46  ? 643 LEU A CD2 1 
ATOM   3738 N N   . PRO A 1 663 ? 11.225  72.331  100.325 1.00 59.02  ? 644 PRO A N   1 
ATOM   3739 C CA  . PRO A 1 663 ? 12.537  71.767  100.677 1.00 58.92  ? 644 PRO A CA  1 
ATOM   3740 C C   . PRO A 1 663 ? 13.007  70.872  99.557  1.00 65.49  ? 644 PRO A C   1 
ATOM   3741 O O   . PRO A 1 663 ? 12.210  70.431  98.731  1.00 66.52  ? 644 PRO A O   1 
ATOM   3742 C CB  . PRO A 1 663 ? 12.253  70.962  101.932 1.00 59.56  ? 644 PRO A CB  1 
ATOM   3743 C CG  . PRO A 1 663 ? 10.755  70.670  101.833 1.00 61.34  ? 644 PRO A CG  1 
ATOM   3744 C CD  . PRO A 1 663 ? 10.144  71.875  101.212 1.00 59.03  ? 644 PRO A CD  1 
ATOM   3745 N N   . GLU A 1 664 ? 14.309  70.587  99.508  1.00 70.71  ? 645 GLU A N   1 
ATOM   3746 C CA  . GLU A 1 664 ? 14.753  69.907  98.293  1.00 71.84  ? 645 GLU A CA  1 
ATOM   3747 C C   . GLU A 1 664 ? 14.170  68.491  98.252  1.00 74.00  ? 645 GLU A C   1 
ATOM   3748 O O   . GLU A 1 664 ? 13.773  68.001  97.182  1.00 75.48  ? 645 GLU A O   1 
ATOM   3749 C CB  . GLU A 1 664 ? 16.278  69.842  98.170  1.00 71.92  ? 645 GLU A CB  1 
ATOM   3750 C CG  . GLU A 1 664 ? 16.961  68.722  98.915  1.00 83.11  ? 645 GLU A CG  1 
ATOM   3751 C CD  . GLU A 1 664 ? 16.973  67.456  98.005  1.00 97.42  ? 645 GLU A CD  1 
ATOM   3752 O OE1 . GLU A 1 664 ? 16.775  67.629  96.777  1.00 96.29  ? 645 GLU A OE1 1 
ATOM   3753 O OE2 . GLU A 1 664 ? 17.157  66.309  98.488  1.00 101.09 ? 645 GLU A OE2 1 
ATOM   3754 N N   . TRP A 1 665 ? 14.082  67.829  99.414  1.00 67.19  ? 646 TRP A N   1 
ATOM   3755 C CA  . TRP A 1 665 ? 13.522  66.487  99.440  1.00 65.21  ? 646 TRP A CA  1 
ATOM   3756 C C   . TRP A 1 665 ? 12.195  66.421  98.694  1.00 67.45  ? 646 TRP A C   1 
ATOM   3757 O O   . TRP A 1 665 ? 11.870  65.382  98.101  1.00 71.00  ? 646 TRP A O   1 
ATOM   3758 C CB  . TRP A 1 665 ? 13.392  65.984  100.889 1.00 58.92  ? 646 TRP A CB  1 
ATOM   3759 C CG  . TRP A 1 665 ? 12.352  66.601  101.721 1.00 56.90  ? 646 TRP A CG  1 
ATOM   3760 C CD1 . TRP A 1 665 ? 12.544  67.510  102.717 1.00 58.10  ? 646 TRP A CD1 1 
ATOM   3761 C CD2 . TRP A 1 665 ? 10.948  66.331  101.690 1.00 58.83  ? 646 TRP A CD2 1 
ATOM   3762 N NE1 . TRP A 1 665 ? 11.340  67.855  103.287 1.00 54.82  ? 646 TRP A NE1 1 
ATOM   3763 C CE2 . TRP A 1 665 ? 10.340  67.152  102.671 1.00 57.83  ? 646 TRP A CE2 1 
ATOM   3764 C CE3 . TRP A 1 665 ? 10.140  65.514  100.906 1.00 59.62  ? 646 TRP A CE3 1 
ATOM   3765 C CZ2 . TRP A 1 665 ? 8.962   67.158  102.904 1.00 55.18  ? 646 TRP A CZ2 1 
ATOM   3766 C CZ3 . TRP A 1 665 ? 8.766   65.526  101.136 1.00 66.50  ? 646 TRP A CZ3 1 
ATOM   3767 C CH2 . TRP A 1 665 ? 8.194   66.334  102.140 1.00 62.85  ? 646 TRP A CH2 1 
ATOM   3768 N N   . LYS A 1 666 ? 11.445  67.524  98.653  1.00 62.94  ? 647 LYS A N   1 
ATOM   3769 C CA  . LYS A 1 666 ? 10.215  67.524  97.879  1.00 61.74  ? 647 LYS A CA  1 
ATOM   3770 C C   . LYS A 1 666 ? 10.481  67.837  96.411  1.00 64.70  ? 647 LYS A C   1 
ATOM   3771 O O   . LYS A 1 666 ? 9.987   67.135  95.526  1.00 67.43  ? 647 LYS A O   1 
ATOM   3772 C CB  . LYS A 1 666 ? 9.215   68.505  98.478  1.00 57.18  ? 647 LYS A CB  1 
ATOM   3773 C CG  . LYS A 1 666 ? 8.012   68.797  97.594  1.00 59.27  ? 647 LYS A CG  1 
ATOM   3774 C CD  . LYS A 1 666 ? 6.930   67.774  97.767  1.00 64.87  ? 647 LYS A CD  1 
ATOM   3775 C CE  . LYS A 1 666 ? 6.578   67.642  99.235  1.00 64.12  ? 647 LYS A CE  1 
ATOM   3776 N NZ  . LYS A 1 666 ? 5.317   66.880  99.439  1.00 66.54  ? 647 LYS A NZ  1 
ATOM   3777 N N   . THR A 1 667 ? 11.261  68.886  96.132  1.00 67.88  ? 648 THR A N   1 
ATOM   3778 C CA  . THR A 1 667 ? 11.520  69.269  94.745  1.00 66.70  ? 648 THR A CA  1 
ATOM   3779 C C   . THR A 1 667 ? 12.233  68.155  93.999  1.00 71.85  ? 648 THR A C   1 
ATOM   3780 O O   . THR A 1 667 ? 11.995  67.957  92.799  1.00 74.76  ? 648 THR A O   1 
ATOM   3781 C CB  . THR A 1 667 ? 12.356  70.555  94.676  1.00 64.73  ? 648 THR A CB  1 
ATOM   3782 O OG1 . THR A 1 667 ? 13.730  70.231  94.902  1.00 70.43  ? 648 THR A OG1 1 
ATOM   3783 C CG2 . THR A 1 667 ? 11.933  71.555  95.727  1.00 58.90  ? 648 THR A CG2 1 
ATOM   3784 N N   . SER A 1 668 ? 13.090  67.398  94.698  1.00 72.66  ? 649 SER A N   1 
ATOM   3785 C CA  . SER A 1 668 ? 13.803  66.291  94.061  1.00 73.54  ? 649 SER A CA  1 
ATOM   3786 C C   . SER A 1 668 ? 12.861  65.175  93.672  1.00 65.85  ? 649 SER A C   1 
ATOM   3787 O O   . SER A 1 668 ? 12.896  64.703  92.537  1.00 71.68  ? 649 SER A O   1 
ATOM   3788 C CB  . SER A 1 668 ? 14.892  65.761  94.968  1.00 73.59  ? 649 SER A CB  1 
ATOM   3789 O OG  . SER A 1 668 ? 15.912  66.727  95.019  1.00 84.32  ? 649 SER A OG  1 
ATOM   3790 N N   . ALA A 1 669 ? 11.976  64.814  94.572  1.00 65.57  ? 650 ALA A N   1 
ATOM   3791 C CA  . ALA A 1 669 ? 10.982  63.791  94.231  1.00 62.41  ? 650 ALA A CA  1 
ATOM   3792 C C   . ALA A 1 669 ? 10.155  64.313  93.077  1.00 63.54  ? 650 ALA A C   1 
ATOM   3793 O O   . ALA A 1 669 ? 9.598   63.534  92.384  1.00 68.72  ? 650 ALA A O   1 
ATOM   3794 C CB  . ALA A 1 669 ? 10.106  63.567  95.410  1.00 64.73  ? 650 ALA A CB  1 
ATOM   3795 N N   . VAL A 1 670 ? 10.133  65.610  92.865  1.00 63.33  ? 651 VAL A N   1 
ATOM   3796 C CA  . VAL A 1 670 ? 9.286   66.105  91.755  1.00 64.18  ? 651 VAL A CA  1 
ATOM   3797 C C   . VAL A 1 670 ? 10.036  65.954  90.448  1.00 64.91  ? 651 VAL A C   1 
ATOM   3798 O O   . VAL A 1 670 ? 9.425   65.639  89.474  1.00 63.74  ? 651 VAL A O   1 
ATOM   3799 C CB  . VAL A 1 670 ? 8.858   67.555  91.977  1.00 64.96  ? 651 VAL A CB  1 
ATOM   3800 C CG1 . VAL A 1 670 ? 8.206   68.106  90.739  1.00 65.85  ? 651 VAL A CG1 1 
ATOM   3801 C CG2 . VAL A 1 670 ? 7.903   67.666  93.135  1.00 62.95  ? 651 VAL A CG2 1 
ATOM   3802 N N   . GLN A 1 671 ? 11.327  66.208  90.431  1.00 62.94  ? 652 GLN A N   1 
ATOM   3803 C CA  . GLN A 1 671 ? 12.017  66.034  89.145  1.00 68.80  ? 652 GLN A CA  1 
ATOM   3804 C C   . GLN A 1 671 ? 12.140  64.546  88.905  1.00 65.62  ? 652 GLN A C   1 
ATOM   3805 O O   . GLN A 1 671 ? 11.954  64.113  87.796  1.00 71.43  ? 652 GLN A O   1 
ATOM   3806 C CB  . GLN A 1 671 ? 13.432  66.574  89.228  1.00 72.48  ? 652 GLN A CB  1 
ATOM   3807 C CG  . GLN A 1 671 ? 13.508  68.084  89.227  1.00 91.16  ? 652 GLN A CG  1 
ATOM   3808 C CD  . GLN A 1 671 ? 14.790  68.517  89.886  1.00 114.39 ? 652 GLN A CD  1 
ATOM   3809 O OE1 . GLN A 1 671 ? 15.801  67.831  89.802  1.00 116.02 ? 652 GLN A OE1 1 
ATOM   3810 N NE2 . GLN A 1 671 ? 14.755  69.646  90.568  1.00 104.57 ? 652 GLN A NE2 1 
ATOM   3811 N N   . ARG A 1 672 ? 12.425  63.802  89.955  1.00 62.61  ? 653 ARG A N   1 
ATOM   3812 C CA  . ARG A 1 672 ? 12.628  62.349  89.828  1.00 59.14  ? 653 ARG A CA  1 
ATOM   3813 C C   . ARG A 1 672 ? 11.408  61.716  89.206  1.00 63.02  ? 653 ARG A C   1 
ATOM   3814 O O   . ARG A 1 672 ? 11.563  61.008  88.262  1.00 67.10  ? 653 ARG A O   1 
ATOM   3815 C CB  . ARG A 1 672 ? 12.753  61.729  91.208  1.00 60.60  ? 653 ARG A CB  1 
ATOM   3816 C CG  . ARG A 1 672 ? 14.180  61.477  91.643  1.00 61.45  ? 653 ARG A CG  1 
ATOM   3817 C CD  . ARG A 1 672 ? 14.085  60.273  92.512  1.00 62.62  ? 653 ARG A CD  1 
ATOM   3818 N NE  . ARG A 1 672 ? 13.441  60.621  93.744  1.00 58.08  ? 653 ARG A NE  1 
ATOM   3819 C CZ  . ARG A 1 672 ? 13.986  61.450  94.583  1.00 67.80  ? 653 ARG A CZ  1 
ATOM   3820 N NH1 . ARG A 1 672 ? 15.130  62.008  94.274  1.00 78.33  ? 653 ARG A NH1 1 
ATOM   3821 N NH2 . ARG A 1 672 ? 13.390  61.751  95.708  1.00 70.66  ? 653 ARG A NH2 1 
ATOM   3822 N N   . MET A 1 673 ? 10.225  62.050  89.683  1.00 58.97  ? 654 MET A N   1 
ATOM   3823 C CA  . MET A 1 673 ? 9.002   61.386  89.194  1.00 64.75  ? 654 MET A CA  1 
ATOM   3824 C C   . MET A 1 673 ? 8.706   61.732  87.754  1.00 66.37  ? 654 MET A C   1 
ATOM   3825 O O   . MET A 1 673 ? 9.101   62.765  87.278  1.00 65.62  ? 654 MET A O   1 
ATOM   3826 C CB  . MET A 1 673 ? 7.794   61.801  90.014  1.00 63.30  ? 654 MET A CB  1 
ATOM   3827 C CG  . MET A 1 673 ? 7.746   61.128  91.330  1.00 76.59  ? 654 MET A CG  1 
ATOM   3828 S SD  . MET A 1 673 ? 6.151   61.256  92.061  1.00 87.21  ? 654 MET A SD  1 
ATOM   3829 C CE  . MET A 1 673 ? 6.268   62.840  92.877  1.00 77.55  ? 654 MET A CE  1 
ATOM   3830 N N   . GLY A 1 674 ? 7.899   60.905  87.134  1.00 61.57  ? 655 GLY A N   1 
ATOM   3831 C CA  . GLY A 1 674 ? 7.569   61.164  85.740  1.00 61.99  ? 655 GLY A CA  1 
ATOM   3832 C C   . GLY A 1 674 ? 6.121   61.503  85.560  1.00 63.28  ? 655 GLY A C   1 
ATOM   3833 O O   . GLY A 1 674 ? 5.293   60.886  86.161  1.00 61.11  ? 655 GLY A O   1 
ATOM   3834 N N   . PHE A 1 675 ? 5.886   62.529  84.774  1.00 67.89  ? 656 PHE A N   1 
ATOM   3835 C CA  . PHE A 1 675 ? 4.571   62.971  84.373  1.00 68.90  ? 656 PHE A CA  1 
ATOM   3836 C C   . PHE A 1 675 ? 4.566   62.818  82.869  1.00 68.53  ? 656 PHE A C   1 
ATOM   3837 O O   . PHE A 1 675 ? 5.415   63.399  82.190  1.00 71.41  ? 656 PHE A O   1 
ATOM   3838 C CB  . PHE A 1 675 ? 4.290   64.415  84.800  1.00 62.11  ? 656 PHE A CB  1 
ATOM   3839 C CG  . PHE A 1 675 ? 2.838   64.735  84.882  1.00 59.75  ? 656 PHE A CG  1 
ATOM   3840 C CD1 . PHE A 1 675 ? 1.987   63.964  85.650  1.00 65.45  ? 656 PHE A CD1 1 
ATOM   3841 C CD2 . PHE A 1 675 ? 2.306   65.765  84.159  1.00 57.55  ? 656 PHE A CD2 1 
ATOM   3842 C CE1 . PHE A 1 675 ? 0.625   64.259  85.707  1.00 66.70  ? 656 PHE A CE1 1 
ATOM   3843 C CE2 . PHE A 1 675 ? 0.963   66.060  84.233  1.00 60.95  ? 656 PHE A CE2 1 
ATOM   3844 C CZ  . PHE A 1 675 ? 0.120   65.304  84.992  1.00 58.63  ? 656 PHE A CZ  1 
ATOM   3845 N N   . GLY A 1 676 ? 3.662   61.986  82.362  1.00 66.68  ? 657 GLY A N   1 
ATOM   3846 C CA  . GLY A 1 676 ? 3.626   61.653  80.970  1.00 69.77  ? 657 GLY A CA  1 
ATOM   3847 C C   . GLY A 1 676 ? 2.415   62.207  80.256  1.00 68.52  ? 657 GLY A C   1 
ATOM   3848 O O   . GLY A 1 676 ? 1.695   63.079  80.762  1.00 66.83  ? 657 GLY A O   1 
ATOM   3849 N N   . ASN A 1 677 ? 2.159   61.658  79.081  1.00 69.73  ? 658 ASN A N   1 
ATOM   3850 C CA  . ASN A 1 677 ? 1.299   62.266  78.087  1.00 68.03  ? 658 ASN A CA  1 
ATOM   3851 C C   . ASN A 1 677 ? 0.536   61.171  77.368  1.00 68.90  ? 658 ASN A C   1 
ATOM   3852 O O   . ASN A 1 677 ? 1.116   60.134  77.038  1.00 80.30  ? 658 ASN A O   1 
ATOM   3853 C CB  . ASN A 1 677 ? 2.148   63.061  77.095  1.00 70.68  ? 658 ASN A CB  1 
ATOM   3854 C CG  . ASN A 1 677 ? 1.364   64.098  76.351  1.00 75.04  ? 658 ASN A CG  1 
ATOM   3855 O OD1 . ASN A 1 677 ? 0.143   64.231  76.521  1.00 72.15  ? 658 ASN A OD1 1 
ATOM   3856 N ND2 . ASN A 1 677 ? 2.066   64.857  75.506  1.00 73.88  ? 658 ASN A ND2 1 
ATOM   3857 N N   . LEU A 1 678 ? -0.758  61.378  77.170  1.00 63.63  ? 659 LEU A N   1 
ATOM   3858 C CA  . LEU A 1 678 ? -1.467  60.726  76.087  1.00 70.41  ? 659 LEU A CA  1 
ATOM   3859 C C   . LEU A 1 678 ? -2.616  61.630  75.709  1.00 74.56  ? 659 LEU A C   1 
ATOM   3860 O O   . LEU A 1 678 ? -3.216  62.259  76.575  1.00 77.74  ? 659 LEU A O   1 
ATOM   3861 C CB  . LEU A 1 678 ? -2.000  59.336  76.428  1.00 70.74  ? 659 LEU A CB  1 
ATOM   3862 C CG  . LEU A 1 678 ? -3.192  59.151  77.337  1.00 71.27  ? 659 LEU A CG  1 
ATOM   3863 C CD1 . LEU A 1 678 ? -4.485  59.282  76.598  1.00 76.64  ? 659 LEU A CD1 1 
ATOM   3864 C CD2 . LEU A 1 678 ? -3.107  57.765  77.824  1.00 78.62  ? 659 LEU A CD2 1 
ATOM   3865 N N   . ASN A 1 679 ? -2.939  61.676  74.418  1.00 78.94  ? 660 ASN A N   1 
ATOM   3866 C CA  . ASN A 1 679 ? -3.992  62.550  73.925  1.00 76.39  ? 660 ASN A CA  1 
ATOM   3867 C C   . ASN A 1 679 ? -5.098  61.750  73.255  1.00 77.15  ? 660 ASN A C   1 
ATOM   3868 O O   . ASN A 1 679 ? -4.944  60.563  72.979  1.00 81.97  ? 660 ASN A O   1 
ATOM   3869 C CB  . ASN A 1 679 ? -3.405  63.580  72.989  1.00 74.91  ? 660 ASN A CB  1 
ATOM   3870 C CG  . ASN A 1 679 ? -2.858  64.744  73.750  1.00 79.98  ? 660 ASN A CG  1 
ATOM   3871 O OD1 . ASN A 1 679 ? -3.586  65.372  74.517  1.00 77.06  ? 660 ASN A OD1 1 
ATOM   3872 N ND2 . ASN A 1 679 ? -1.567  65.017  73.594  1.00 81.88  ? 660 ASN A ND2 1 
ATOM   3873 N N   . LYS A 1 680 ? -6.239  62.395  73.033  1.00 74.55  ? 661 LYS A N   1 
ATOM   3874 C CA  . LYS A 1 680 ? -7.380  61.734  72.412  1.00 78.77  ? 661 LYS A CA  1 
ATOM   3875 C C   . LYS A 1 680 ? -7.922  62.570  71.268  1.00 87.96  ? 661 LYS A C   1 
ATOM   3876 O O   . LYS A 1 680 ? -7.899  63.807  71.315  1.00 88.51  ? 661 LYS A O   1 
ATOM   3877 C CB  . LYS A 1 680 ? -8.507  61.498  73.387  1.00 71.38  ? 661 LYS A CB  1 
ATOM   3878 C CG  . LYS A 1 680 ? -8.157  60.578  74.472  1.00 74.39  ? 661 LYS A CG  1 
ATOM   3879 C CD  . LYS A 1 680 ? -9.308  60.462  75.423  1.00 78.26  ? 661 LYS A CD  1 
ATOM   3880 C CE  . LYS A 1 680 ? -8.940  59.519  76.516  1.00 81.93  ? 661 LYS A CE  1 
ATOM   3881 N NZ  . LYS A 1 680 ? -10.064 59.397  77.416  1.00 87.51  ? 661 LYS A NZ  1 
ATOM   3882 N N   . VAL A 1 681 ? -8.433  61.888  70.241  1.00 87.38  ? 662 VAL A N   1 
ATOM   3883 C CA  . VAL A 1 681 ? -9.161  62.538  69.160  1.00 85.64  ? 662 VAL A CA  1 
ATOM   3884 C C   . VAL A 1 681 ? -10.599 62.058  69.203  1.00 86.68  ? 662 VAL A C   1 
ATOM   3885 O O   . VAL A 1 681 ? -10.861 60.848  69.214  1.00 92.01  ? 662 VAL A O   1 
ATOM   3886 C CB  . VAL A 1 681 ? -8.546  62.254  67.784  1.00 84.64  ? 662 VAL A CB  1 
ATOM   3887 C CG1 . VAL A 1 681 ? -9.368  62.976  66.750  1.00 91.79  ? 662 VAL A CG1 1 
ATOM   3888 C CG2 . VAL A 1 681 ? -7.090  62.698  67.720  1.00 81.81  ? 662 VAL A CG2 1 
ATOM   3889 N N   . VAL A 1 682 ? -11.532 62.994  69.231  1.00 86.87  ? 663 VAL A N   1 
ATOM   3890 C CA  . VAL A 1 682 ? -12.942 62.645  69.277  1.00 96.90  ? 663 VAL A CA  1 
ATOM   3891 C C   . VAL A 1 682 ? -13.543 62.837  67.896  1.00 105.21 ? 663 VAL A C   1 
ATOM   3892 O O   . VAL A 1 682 ? -13.625 63.967  67.391  1.00 103.01 ? 663 VAL A O   1 
ATOM   3893 C CB  . VAL A 1 682 ? -13.707 63.466  70.314  1.00 100.76 ? 663 VAL A CB  1 
ATOM   3894 C CG1 . VAL A 1 682 ? -15.062 62.830  70.511  1.00 102.38 ? 663 VAL A CG1 1 
ATOM   3895 C CG2 . VAL A 1 682 ? -12.940 63.513  71.592  1.00 98.95  ? 663 VAL A CG2 1 
ATOM   3896 N N   . LEU A 1 683 ? -13.989 61.725  67.308  1.00 113.35 ? 664 LEU A N   1 
ATOM   3897 C CA  . LEU A 1 683 ? -14.612 61.688  65.990  1.00 104.67 ? 664 LEU A CA  1 
ATOM   3898 C C   . LEU A 1 683 ? -16.103 61.458  66.191  1.00 106.28 ? 664 LEU A C   1 
ATOM   3899 O O   . LEU A 1 683 ? -16.543 60.350  66.534  1.00 100.90 ? 664 LEU A O   1 
ATOM   3900 C CB  . LEU A 1 683 ? -13.966 60.620  65.127  1.00 102.00 ? 664 LEU A CB  1 
ATOM   3901 C CG  . LEU A 1 683 ? -12.498 60.987  64.924  1.00 97.42  ? 664 LEU A CG  1 
ATOM   3902 C CD1 . LEU A 1 683 ? -11.751 59.844  64.289  1.00 99.77  ? 664 LEU A CD1 1 
ATOM   3903 C CD2 . LEU A 1 683 ? -12.357 62.264  64.110  1.00 91.07  ? 664 LEU A CD2 1 
ATOM   3904 N N   . CYS A 1 684 ? -16.850 62.504  65.858  1.00 110.71 ? 665 CYS A N   1 
ATOM   3905 C CA  . CYS A 1 684 ? -18.324 62.558  65.961  1.00 120.96 ? 665 CYS A CA  1 
ATOM   3906 C C   . CYS A 1 684 ? -18.975 62.306  64.603  1.00 123.04 ? 665 CYS A C   1 
ATOM   3907 O O   . CYS A 1 684 ? -18.799 63.131  63.711  1.00 119.27 ? 665 CYS A O   1 
ATOM   3908 C CB  . CYS A 1 684 ? -18.716 63.962  66.371  1.00 119.51 ? 665 CYS A CB  1 
ATOM   3909 S SG  . CYS A 1 684 ? -18.456 64.221  68.132  1.00 115.25 ? 665 CYS A SG  1 
ATOM   3910 N N   . PHE A 1 685 ? -19.762 61.243  64.486  1.00 122.45 ? 666 PHE A N   1 
ATOM   3911 C CA  . PHE A 1 685 ? -20.398 60.956  63.184  1.00 122.41 ? 666 PHE A CA  1 
ATOM   3912 C C   . PHE A 1 685 ? -21.872 60.622  63.377  1.00 128.39 ? 666 PHE A C   1 
ATOM   3913 O O   . PHE A 1 685 ? -22.229 60.131  64.458  1.00 128.29 ? 666 PHE A O   1 
ATOM   3914 C CB  . PHE A 1 685 ? -19.726 59.741  62.559  1.00 122.50 ? 666 PHE A CB  1 
ATOM   3915 C CG  . PHE A 1 685 ? -18.291 59.969  62.194  1.00 113.87 ? 666 PHE A CG  1 
ATOM   3916 C CD1 . PHE A 1 685 ? -17.932 61.054  61.426  1.00 113.65 ? 666 PHE A CD1 1 
ATOM   3917 C CD2 . PHE A 1 685 ? -17.316 59.090  62.604  1.00 107.69 ? 666 PHE A CD2 1 
ATOM   3918 C CE1 . PHE A 1 685 ? -16.613 61.274  61.090  1.00 113.50 ? 666 PHE A CE1 1 
ATOM   3919 C CE2 . PHE A 1 685 ? -15.998 59.306  62.262  1.00 105.60 ? 666 PHE A CE2 1 
ATOM   3920 C CZ  . PHE A 1 685 ? -15.651 60.393  61.506  1.00 108.86 ? 666 PHE A CZ  1 
ATOM   3921 N N   . ASP A 1 686 ? -22.676 60.960  62.366  1.00 133.68 ? 667 ASP A N   1 
ATOM   3922 C CA  . ASP A 1 686 ? -24.136 60.691  62.283  1.00 132.40 ? 667 ASP A CA  1 
ATOM   3923 C C   . ASP A 1 686 ? -24.429 59.204  62.090  1.00 130.01 ? 667 ASP A C   1 
ATOM   3924 O O   . ASP A 1 686 ? -25.429 58.739  62.634  1.00 127.54 ? 667 ASP A O   1 
ATOM   3925 C CB  . ASP A 1 686 ? -24.735 61.416  61.093  1.00 120.58 ? 667 ASP A CB  1 
ATOM   3926 C CG  . ASP A 1 686 ? -23.711 61.461  59.994  1.00 129.93 ? 667 ASP A CG  1 
ATOM   3927 O OD1 . ASP A 1 686 ? -22.872 60.559  59.976  1.00 127.89 ? 667 ASP A OD1 1 
ATOM   3928 O OD2 . ASP A 1 686 ? -23.740 62.408  59.212  1.00 139.05 ? 667 ASP A OD2 1 
ATOM   3929 N N   . ARG A 1 687 ? -23.627 58.493  61.299  1.00 127.19 ? 668 ARG A N   1 
ATOM   3930 C CA  . ARG A 1 687 ? -23.972 57.069  61.077  1.00 125.03 ? 668 ARG A CA  1 
ATOM   3931 C C   . ARG A 1 687 ? -22.945 56.142  61.708  1.00 116.30 ? 668 ARG A C   1 
ATOM   3932 O O   . ARG A 1 687 ? -21.787 56.229  61.351  1.00 114.28 ? 668 ARG A O   1 
ATOM   3933 C CB  . ARG A 1 687 ? -24.061 56.737  59.586  1.00 131.46 ? 668 ARG A CB  1 
ATOM   3934 C CG  . ARG A 1 687 ? -23.274 57.652  58.659  1.00 130.83 ? 668 ARG A CG  1 
ATOM   3935 C CD  . ARG A 1 687 ? -23.759 57.577  57.219  1.00 135.89 ? 668 ARG A CD  1 
ATOM   3936 N NE  . ARG A 1 687 ? -23.922 58.887  56.608  1.00 136.58 ? 668 ARG A NE  1 
ATOM   3937 C CZ  . ARG A 1 687 ? -25.058 59.570  56.572  1.00 137.39 ? 668 ARG A CZ  1 
ATOM   3938 N NH1 . ARG A 1 687 ? -26.159 59.068  57.101  1.00 128.27 ? 668 ARG A NH1 1 
ATOM   3939 N NH2 . ARG A 1 687 ? -25.095 60.759  56.008  1.00 140.32 ? 668 ARG A NH2 1 
ATOM   3940 N N   . VAL A 1 688 ? -23.393 55.219  62.541  1.00 108.53 ? 669 VAL A N   1 
ATOM   3941 C CA  . VAL A 1 688 ? -22.411 54.264  63.103  1.00 115.02 ? 669 VAL A CA  1 
ATOM   3942 C C   . VAL A 1 688 ? -22.012 53.381  61.929  1.00 120.12 ? 669 VAL A C   1 
ATOM   3943 O O   . VAL A 1 688 ? -22.883 52.694  61.411  1.00 120.62 ? 669 VAL A O   1 
ATOM   3944 C CB  . VAL A 1 688 ? -23.097 53.404  64.171  1.00 117.67 ? 669 VAL A CB  1 
ATOM   3945 C CG1 . VAL A 1 688 ? -22.775 51.936  64.000  1.00 118.93 ? 669 VAL A CG1 1 
ATOM   3946 C CG2 . VAL A 1 688 ? -22.760 53.858  65.573  1.00 117.22 ? 669 VAL A CG2 1 
ATOM   3947 N N   . PHE A 1 689 ? -20.742 53.373  61.553  1.00 116.87 ? 670 PHE A N   1 
ATOM   3948 C CA  . PHE A 1 689 ? -20.334 52.541  60.400  1.00 111.83 ? 670 PHE A CA  1 
ATOM   3949 C C   . PHE A 1 689 ? -19.251 51.567  60.820  1.00 110.23 ? 670 PHE A C   1 
ATOM   3950 O O   . PHE A 1 689 ? -18.416 51.238  60.010  1.00 112.86 ? 670 PHE A O   1 
ATOM   3951 C CB  . PHE A 1 689 ? -19.787 53.418  59.291  1.00 109.02 ? 670 PHE A CB  1 
ATOM   3952 C CG  . PHE A 1 689 ? -18.570 54.185  59.702  1.00 112.78 ? 670 PHE A CG  1 
ATOM   3953 C CD1 . PHE A 1 689 ? -17.314 53.653  59.529  1.00 117.24 ? 670 PHE A CD1 1 
ATOM   3954 C CD2 . PHE A 1 689 ? -18.691 55.435  60.264  1.00 117.13 ? 670 PHE A CD2 1 
ATOM   3955 C CE1 . PHE A 1 689 ? -16.192 54.369  59.898  1.00 120.97 ? 670 PHE A CE1 1 
ATOM   3956 C CE2 . PHE A 1 689 ? -17.566 56.150  60.629  1.00 118.95 ? 670 PHE A CE2 1 
ATOM   3957 C CZ  . PHE A 1 689 ? -16.321 55.614  60.445  1.00 118.86 ? 670 PHE A CZ  1 
ATOM   3958 N N   . TRP A 1 690 ? -19.238 51.194  62.085  1.00 111.45 ? 671 TRP A N   1 
ATOM   3959 C CA  . TRP A 1 690 ? -18.216 50.238  62.556  1.00 112.27 ? 671 TRP A CA  1 
ATOM   3960 C C   . TRP A 1 690 ? -18.907 49.075  63.237  1.00 106.51 ? 671 TRP A C   1 
ATOM   3961 O O   . TRP A 1 690 ? -20.125 49.101  63.396  1.00 104.01 ? 671 TRP A O   1 
ATOM   3962 C CB  . TRP A 1 690 ? -17.277 50.917  63.544  1.00 121.09 ? 671 TRP A CB  1 
ATOM   3963 C CG  . TRP A 1 690 ? -17.995 51.728  64.572  1.00 117.02 ? 671 TRP A CG  1 
ATOM   3964 C CD1 . TRP A 1 690 ? -18.557 51.294  65.732  1.00 114.26 ? 671 TRP A CD1 1 
ATOM   3965 C CD2 . TRP A 1 690 ? -18.230 53.137  64.520  1.00 110.41 ? 671 TRP A CD2 1 
ATOM   3966 N NE1 . TRP A 1 690 ? -19.127 52.337  66.403  1.00 114.27 ? 671 TRP A NE1 1 
ATOM   3967 C CE2 . TRP A 1 690 ? -18.942 53.477  65.679  1.00 111.62 ? 671 TRP A CE2 1 
ATOM   3968 C CE3 . TRP A 1 690 ? -17.906 54.133  63.605  1.00 110.29 ? 671 TRP A CE3 1 
ATOM   3969 C CZ2 . TRP A 1 690 ? -19.338 54.776  65.942  1.00 113.69 ? 671 TRP A CZ2 1 
ATOM   3970 C CZ3 . TRP A 1 690 ? -18.298 55.420  63.866  1.00 111.84 ? 671 TRP A CZ3 1 
ATOM   3971 C CH2 . TRP A 1 690 ? -19.004 55.731  65.019  1.00 113.57 ? 671 TRP A CH2 1 
ATOM   3972 N N   . ASP A 1 691 ? -18.127 48.104  63.669  1.00 103.59 ? 672 ASP A N   1 
ATOM   3973 C CA  . ASP A 1 691 ? -18.829 47.017  64.319  1.00 108.47 ? 672 ASP A CA  1 
ATOM   3974 C C   . ASP A 1 691 ? -19.299 47.459  65.706  1.00 118.80 ? 672 ASP A C   1 
ATOM   3975 O O   . ASP A 1 691 ? -18.483 47.596  66.631  1.00 118.91 ? 672 ASP A O   1 
ATOM   3976 C CB  . ASP A 1 691 ? -17.921 45.796  64.398  1.00 112.84 ? 672 ASP A CB  1 
ATOM   3977 C CG  . ASP A 1 691 ? -18.654 44.566  64.860  1.00 118.16 ? 672 ASP A CG  1 
ATOM   3978 O OD1 . ASP A 1 691 ? -19.811 44.710  65.319  1.00 115.58 ? 672 ASP A OD1 1 
ATOM   3979 O OD2 . ASP A 1 691 ? -18.069 43.460  64.787  1.00 120.89 ? 672 ASP A OD2 1 
ATOM   3980 N N   . PRO A 1 692 ? -20.607 47.662  65.900  1.00 118.43 ? 673 PRO A N   1 
ATOM   3981 C CA  . PRO A 1 692 ? -21.097 48.173  67.190  1.00 118.31 ? 673 PRO A CA  1 
ATOM   3982 C C   . PRO A 1 692 ? -21.006 47.173  68.325  1.00 114.82 ? 673 PRO A C   1 
ATOM   3983 O O   . PRO A 1 692 ? -21.302 47.537  69.471  1.00 116.45 ? 673 PRO A O   1 
ATOM   3984 C CB  . PRO A 1 692 ? -22.564 48.519  66.898  1.00 113.56 ? 673 PRO A CB  1 
ATOM   3985 C CG  . PRO A 1 692 ? -22.673 48.507  65.418  1.00 114.61 ? 673 PRO A CG  1 
ATOM   3986 C CD  . PRO A 1 692 ? -21.713 47.471  64.959  1.00 114.17 ? 673 PRO A CD  1 
ATOM   3987 N N   . SER A 1 693 ? -20.635 45.930  68.055  1.00 113.41 ? 674 SER A N   1 
ATOM   3988 C CA  . SER A 1 693 ? -20.490 44.954  69.124  1.00 123.32 ? 674 SER A CA  1 
ATOM   3989 C C   . SER A 1 693 ? -19.057 44.854  69.619  1.00 123.11 ? 674 SER A C   1 
ATOM   3990 O O   . SER A 1 693 ? -18.784 44.063  70.535  1.00 123.24 ? 674 SER A O   1 
ATOM   3991 C CB  . SER A 1 693 ? -20.977 43.570  68.675  1.00 125.14 ? 674 SER A CB  1 
ATOM   3992 O OG  . SER A 1 693 ? -20.201 43.069  67.598  1.00 126.66 ? 674 SER A OG  1 
ATOM   3993 N N   . VAL A 1 694 ? -18.140 45.617  69.030  1.00 118.22 ? 675 VAL A N   1 
ATOM   3994 C CA  . VAL A 1 694 ? -16.790 45.753  69.556  1.00 121.68 ? 675 VAL A CA  1 
ATOM   3995 C C   . VAL A 1 694 ? -16.630 47.183  70.056  1.00 121.04 ? 675 VAL A C   1 
ATOM   3996 O O   . VAL A 1 694 ? -16.901 48.149  69.322  1.00 118.16 ? 675 VAL A O   1 
ATOM   3997 C CB  . VAL A 1 694 ? -15.724 45.368  68.516  1.00 112.99 ? 675 VAL A CB  1 
ATOM   3998 C CG1 . VAL A 1 694 ? -15.942 43.924  68.075  1.00 114.78 ? 675 VAL A CG1 1 
ATOM   3999 C CG2 . VAL A 1 694 ? -15.727 46.312  67.330  1.00 104.23 ? 675 VAL A CG2 1 
ATOM   4000 N N   . ASN A 1 695 ? -16.246 47.319  71.328  1.00 114.00 ? 676 ASN A N   1 
ATOM   4001 C CA  . ASN A 1 695 ? -16.052 48.653  71.871  1.00 115.34 ? 676 ASN A CA  1 
ATOM   4002 C C   . ASN A 1 695 ? -14.762 49.274  71.372  1.00 114.22 ? 676 ASN A C   1 
ATOM   4003 O O   . ASN A 1 695 ? -14.701 50.493  71.159  1.00 113.13 ? 676 ASN A O   1 
ATOM   4004 C CB  . ASN A 1 695 ? -16.048 48.622  73.397  1.00 115.19 ? 676 ASN A CB  1 
ATOM   4005 C CG  . ASN A 1 695 ? -17.099 47.712  73.955  1.00 121.64 ? 676 ASN A CG  1 
ATOM   4006 O OD1 . ASN A 1 695 ? -16.791 46.739  74.640  1.00 123.00 ? 676 ASN A OD1 1 
ATOM   4007 N ND2 . ASN A 1 695 ? -18.358 48.015  73.660  1.00 123.03 ? 676 ASN A ND2 1 
ATOM   4008 N N   . LEU A 1 696 ? -13.737 48.457  71.168  1.00 107.08 ? 677 LEU A N   1 
ATOM   4009 C CA  . LEU A 1 696 ? -12.412 48.959  70.863  1.00 104.48 ? 677 LEU A CA  1 
ATOM   4010 C C   . LEU A 1 696 ? -11.782 48.102  69.776  1.00 102.01 ? 677 LEU A C   1 
ATOM   4011 O O   . LEU A 1 696 ? -12.047 46.904  69.680  1.00 109.33 ? 677 LEU A O   1 
ATOM   4012 C CB  . LEU A 1 696 ? -11.558 49.019  72.149  1.00 104.39 ? 677 LEU A CB  1 
ATOM   4013 C CG  . LEU A 1 696 ? -11.109 47.740  72.868  1.00 114.11 ? 677 LEU A CG  1 
ATOM   4014 C CD1 . LEU A 1 696 ? -10.000 48.007  73.898  1.00 109.63 ? 677 LEU A CD1 1 
ATOM   4015 C CD2 . LEU A 1 696 ? -12.295 47.062  73.549  1.00 118.23 ? 677 LEU A CD2 1 
ATOM   4016 N N   . PHE A 1 697 ? -10.982 48.741  68.928  1.00 95.70  ? 678 PHE A N   1 
ATOM   4017 C CA  . PHE A 1 697 ? -10.284 48.041  67.860  1.00 94.00  ? 678 PHE A CA  1 
ATOM   4018 C C   . PHE A 1 697 ? -9.020  48.806  67.495  1.00 90.36  ? 678 PHE A C   1 
ATOM   4019 O O   . PHE A 1 697 ? -8.996  50.036  67.517  1.00 92.78  ? 678 PHE A O   1 
ATOM   4020 C CB  . PHE A 1 697 ? -11.179 47.848  66.637  1.00 92.31  ? 678 PHE A CB  1 
ATOM   4021 C CG  . PHE A 1 697 ? -11.526 49.107  65.913  1.00 81.70  ? 678 PHE A CG  1 
ATOM   4022 C CD1 . PHE A 1 697 ? -12.810 49.614  65.978  1.00 89.18  ? 678 PHE A CD1 1 
ATOM   4023 C CD2 . PHE A 1 697 ? -10.600 49.747  65.105  1.00 81.69  ? 678 PHE A CD2 1 
ATOM   4024 C CE1 . PHE A 1 697 ? -13.157 50.777  65.277  1.00 96.73  ? 678 PHE A CE1 1 
ATOM   4025 C CE2 . PHE A 1 697 ? -10.929 50.916  64.413  1.00 87.69  ? 678 PHE A CE2 1 
ATOM   4026 C CZ  . PHE A 1 697 ? -12.208 51.431  64.493  1.00 90.91  ? 678 PHE A CZ  1 
ATOM   4027 N N   . GLY A 1 698 ? -7.972  48.073  67.143  1.00 91.15  ? 679 GLY A N   1 
ATOM   4028 C CA  . GLY A 1 698 ? -6.662  48.660  66.965  1.00 90.03  ? 679 GLY A CA  1 
ATOM   4029 C C   . GLY A 1 698 ? -6.337  49.003  65.516  1.00 89.65  ? 679 GLY A C   1 
ATOM   4030 O O   . GLY A 1 698 ? -7.067  48.663  64.595  1.00 92.96  ? 679 GLY A O   1 
ATOM   4031 N N   . HIS A 1 699 ? -5.176  49.611  65.350  1.00 82.87  ? 680 HIS A N   1 
ATOM   4032 C CA  . HIS A 1 699 ? -4.605  49.934  64.033  1.00 80.25  ? 680 HIS A CA  1 
ATOM   4033 C C   . HIS A 1 699 ? -3.115  49.761  64.214  1.00 88.29  ? 680 HIS A C   1 
ATOM   4034 O O   . HIS A 1 699 ? -2.591  50.370  65.104  1.00 87.80  ? 680 HIS A O   1 
ATOM   4035 C CB  . HIS A 1 699 ? -4.862  51.377  63.673  1.00 85.94  ? 680 HIS A CB  1 
ATOM   4036 C CG  . HIS A 1 699 ? -3.818  51.931  62.778  1.00 94.51  ? 680 HIS A CG  1 
ATOM   4037 N ND1 . HIS A 1 699 ? -4.070  52.237  61.481  1.00 99.28  ? 680 HIS A ND1 1 
ATOM   4038 C CD2 . HIS A 1 699 ? -2.534  52.254  62.992  1.00 95.81  ? 680 HIS A CD2 1 
ATOM   4039 C CE1 . HIS A 1 699 ? -2.988  52.718  60.928  1.00 97.81  ? 680 HIS A CE1 1 
ATOM   4040 N NE2 . HIS A 1 699 ? -2.036  52.732  61.826  1.00 97.01  ? 680 HIS A NE2 1 
ATOM   4041 N N   . VAL A 1 700 ? -2.476  48.962  63.384  1.00 90.19  ? 681 VAL A N   1 
ATOM   4042 C CA  . VAL A 1 700 ? -1.021  48.715  63.547  1.00 91.84  ? 681 VAL A CA  1 
ATOM   4043 C C   . VAL A 1 700 ? -0.235  49.759  62.779  1.00 93.04  ? 681 VAL A C   1 
ATOM   4044 O O   . VAL A 1 700 ? -0.323  49.772  61.592  1.00 90.23  ? 681 VAL A O   1 
ATOM   4045 C CB  . VAL A 1 700 ? -0.651  47.314  63.070  1.00 93.61  ? 681 VAL A CB  1 
ATOM   4046 C CG1 . VAL A 1 700 ? 0.742   46.942  63.523  1.00 93.78  ? 681 VAL A CG1 1 
ATOM   4047 C CG2 . VAL A 1 700 ? -1.660  46.316  63.576  1.00 97.84  ? 681 VAL A CG2 1 
ATOM   4048 N N   . GLY A 1 701 ? 0.596   50.517  63.474  1.00 105.19 ? 682 GLY A N   1 
ATOM   4049 C CA  . GLY A 1 701 ? 1.367   51.591  62.834  1.00 105.27 ? 682 GLY A CA  1 
ATOM   4050 C C   . GLY A 1 701 ? 2.379   51.054  61.860  1.00 108.16 ? 682 GLY A C   1 
ATOM   4051 O O   . GLY A 1 701 ? 2.896   49.980  62.085  1.00 108.14 ? 682 GLY A O   1 
ATOM   4052 N N   . SER A 1 702 ? 2.671   51.834  60.831  1.00 109.67 ? 683 SER A N   1 
ATOM   4053 C CA  . SER A 1 702 ? 3.629   51.445  59.774  1.00 108.15 ? 683 SER A CA  1 
ATOM   4054 C C   . SER A 1 702 ? 5.012   51.236  60.373  1.00 109.97 ? 683 SER A C   1 
ATOM   4055 O O   . SER A 1 702 ? 5.704   50.319  59.965  1.00 109.29 ? 683 SER A O   1 
ATOM   4056 C CB  . SER A 1 702 ? 3.730   52.573  58.836  1.00 110.20 ? 683 SER A CB  1 
ATOM   4057 O OG  . SER A 1 702 ? 4.377   53.640  59.504  1.00 114.37 ? 683 SER A OG  1 
ATOM   4058 N N   . THR A 1 703 ? 5.404   52.095  61.294  1.00 106.87 ? 684 THR A N   1 
ATOM   4059 C CA  . THR A 1 703 ? 6.780   51.975  61.806  1.00 108.90 ? 684 THR A CA  1 
ATOM   4060 C C   . THR A 1 703 ? 6.772   52.003  63.321  1.00 105.16 ? 684 THR A C   1 
ATOM   4061 O O   . THR A 1 703 ? 5.824   52.481  63.880  1.00 104.29 ? 684 THR A O   1 
ATOM   4062 C CB  . THR A 1 703 ? 7.583   53.192  61.367  1.00 110.04 ? 684 THR A CB  1 
ATOM   4063 O OG1 . THR A 1 703 ? 8.763   53.247  62.164  1.00 113.74 ? 684 THR A OG1 1 
ATOM   4064 C CG2 . THR A 1 703 ? 6.782   54.458  61.547  1.00 108.43 ? 684 THR A CG2 1 
ATOM   4065 N N   . THR A 1 704 ? 7.867   51.565  63.922  1.00 99.93  ? 685 THR A N   1 
ATOM   4066 C CA  . THR A 1 704 ? 8.016   51.539  65.386  1.00 91.82  ? 685 THR A CA  1 
ATOM   4067 C C   . THR A 1 704 ? 7.941   52.959  65.913  1.00 95.92  ? 685 THR A C   1 
ATOM   4068 O O   . THR A 1 704 ? 7.248   53.185  66.863  1.00 88.58  ? 685 THR A O   1 
ATOM   4069 C CB  . THR A 1 704 ? 9.406   51.032  65.739  1.00 97.64  ? 685 THR A CB  1 
ATOM   4070 O OG1 . THR A 1 704 ? 9.288   49.623  65.861  1.00 106.72 ? 685 THR A OG1 1 
ATOM   4071 C CG2 . THR A 1 704 ? 9.913   51.594  67.041  1.00 94.55  ? 685 THR A CG2 1 
ATOM   4072 N N   . ALA A 1 705 ? 8.569   53.897  65.228  1.00 100.05 ? 686 ALA A N   1 
ATOM   4073 C CA  . ALA A 1 705 ? 8.610   55.260  65.777  1.00 90.74  ? 686 ALA A CA  1 
ATOM   4074 C C   . ALA A 1 705 ? 7.224   55.861  65.731  1.00 90.31  ? 686 ALA A C   1 
ATOM   4075 O O   . ALA A 1 705 ? 7.030   56.900  66.286  1.00 102.75 ? 686 ALA A O   1 
ATOM   4076 C CB  . ALA A 1 705 ? 9.576   56.084  64.994  1.00 90.72  ? 686 ALA A CB  1 
ATOM   4077 N N   . SER A 1 706 ? 6.306   55.241  65.031  1.00 86.30  ? 687 SER A N   1 
ATOM   4078 C CA  . SER A 1 706 ? 4.967   55.856  65.017  1.00 90.66  ? 687 SER A CA  1 
ATOM   4079 C C   . SER A 1 706 ? 3.985   54.841  65.572  1.00 87.67  ? 687 SER A C   1 
ATOM   4080 O O   . SER A 1 706 ? 2.847   54.863  65.166  1.00 83.12  ? 687 SER A O   1 
ATOM   4081 C CB  . SER A 1 706 ? 4.615   56.327  63.652  1.00 88.90  ? 687 SER A CB  1 
ATOM   4082 O OG  . SER A 1 706 ? 3.448   55.694  63.166  1.00 107.98 ? 687 SER A OG  1 
ATOM   4083 N N   . ARG A 1 707 ? 4.432   54.015  66.504  1.00 82.89  ? 688 ARG A N   1 
ATOM   4084 C CA  . ARG A 1 707 ? 3.558   52.936  67.006  1.00 83.40  ? 688 ARG A CA  1 
ATOM   4085 C C   . ARG A 1 707 ? 2.297   53.489  67.655  1.00 85.71  ? 688 ARG A C   1 
ATOM   4086 O O   . ARG A 1 707 ? 1.285   52.842  67.536  1.00 87.77  ? 688 ARG A O   1 
ATOM   4087 C CB  . ARG A 1 707 ? 4.322   51.924  67.857  1.00 78.93  ? 688 ARG A CB  1 
ATOM   4088 C CG  . ARG A 1 707 ? 5.028   52.488  69.072  1.00 77.99  ? 688 ARG A CG  1 
ATOM   4089 C CD  . ARG A 1 707 ? 5.686   51.348  69.801  1.00 79.50  ? 688 ARG A CD  1 
ATOM   4090 N NE  . ARG A 1 707 ? 6.666   51.788  70.765  1.00 77.84  ? 688 ARG A NE  1 
ATOM   4091 C CZ  . ARG A 1 707 ? 7.584   51.002  71.271  1.00 83.76  ? 688 ARG A CZ  1 
ATOM   4092 N NH1 . ARG A 1 707 ? 7.638   49.747  70.899  1.00 93.87  ? 688 ARG A NH1 1 
ATOM   4093 N NH2 . ARG A 1 707 ? 8.455   51.453  72.138  1.00 82.00  ? 688 ARG A NH2 1 
ATOM   4094 N N   . GLY A 1 708 ? 2.365   54.611  68.352  1.00 85.93  ? 689 GLY A N   1 
ATOM   4095 C CA  . GLY A 1 708 ? 1.157   55.108  69.027  1.00 84.68  ? 689 GLY A CA  1 
ATOM   4096 C C   . GLY A 1 708 ? 0.328   56.084  68.227  1.00 85.49  ? 689 GLY A C   1 
ATOM   4097 O O   . GLY A 1 708 ? -0.684  56.501  68.742  1.00 82.26  ? 689 GLY A O   1 
ATOM   4098 N N   . GLU A 1 709 ? 0.696   56.416  67.001  1.00 88.92  ? 690 GLU A N   1 
ATOM   4099 C CA  . GLU A 1 709 ? -0.154  57.418  66.331  1.00 86.28  ? 690 GLU A CA  1 
ATOM   4100 C C   . GLU A 1 709 ? -1.485  56.761  66.032  1.00 87.88  ? 690 GLU A C   1 
ATOM   4101 O O   . GLU A 1 709 ? -1.506  55.923  65.168  1.00 92.49  ? 690 GLU A O   1 
ATOM   4102 C CB  . GLU A 1 709 ? 0.441   57.788  64.985  1.00 88.94  ? 690 GLU A CB  1 
ATOM   4103 C CG  . GLU A 1 709 ? 0.717   59.258  64.874  1.00 93.29  ? 690 GLU A CG  1 
ATOM   4104 C CD  . GLU A 1 709 ? 1.597   59.633  63.711  1.00 107.96 ? 690 GLU A CD  1 
ATOM   4105 O OE1 . GLU A 1 709 ? 2.801   59.857  63.918  1.00 104.99 ? 690 GLU A OE1 1 
ATOM   4106 O OE2 . GLU A 1 709 ? 1.062   59.706  62.613  1.00 112.15 ? 690 GLU A OE2 1 
ATOM   4107 N N   . LEU A 1 710 ? -2.537  57.260  66.661  1.00 85.79  ? 691 LEU A N   1 
ATOM   4108 C CA  . LEU A 1 710 ? -3.919  56.757  66.538  1.00 82.50  ? 691 LEU A CA  1 
ATOM   4109 C C   . LEU A 1 710 ? -3.916  55.246  66.443  1.00 80.06  ? 691 LEU A C   1 
ATOM   4110 O O   . LEU A 1 710 ? -4.448  54.745  65.506  1.00 83.83  ? 691 LEU A O   1 
ATOM   4111 C CB  . LEU A 1 710 ? -4.526  57.372  65.290  1.00 84.92  ? 691 LEU A CB  1 
ATOM   4112 C CG  . LEU A 1 710 ? -4.588  58.888  65.342  1.00 87.71  ? 691 LEU A CG  1 
ATOM   4113 C CD1 . LEU A 1 710 ? -3.256  59.456  64.942  1.00 94.41  ? 691 LEU A CD1 1 
ATOM   4114 C CD2 . LEU A 1 710 ? -5.688  59.415  64.451  1.00 91.88  ? 691 LEU A CD2 1 
ATOM   4115 N N   . PHE A 1 711 ? -3.330  54.579  67.413  1.00 80.10  ? 692 PHE A N   1 
ATOM   4116 C CA  . PHE A 1 711 ? -3.237  53.112  67.347  1.00 77.92  ? 692 PHE A CA  1 
ATOM   4117 C C   . PHE A 1 711 ? -4.420  52.432  68.012  1.00 80.98  ? 692 PHE A C   1 
ATOM   4118 O O   . PHE A 1 711 ? -4.380  51.239  68.076  1.00 86.41  ? 692 PHE A O   1 
ATOM   4119 C CB  . PHE A 1 711 ? -2.016  52.663  68.127  1.00 78.59  ? 692 PHE A CB  1 
ATOM   4120 C CG  . PHE A 1 711 ? -2.302  52.563  69.591  1.00 82.65  ? 692 PHE A CG  1 
ATOM   4121 C CD1 . PHE A 1 711 ? -2.752  53.654  70.285  1.00 85.10  ? 692 PHE A CD1 1 
ATOM   4122 C CD2 . PHE A 1 711 ? -2.147  51.378  70.266  1.00 85.55  ? 692 PHE A CD2 1 
ATOM   4123 C CE1 . PHE A 1 711 ? -3.023  53.561  71.631  1.00 87.58  ? 692 PHE A CE1 1 
ATOM   4124 C CE2 . PHE A 1 711 ? -2.429  51.283  71.611  1.00 81.91  ? 692 PHE A CE2 1 
ATOM   4125 C CZ  . PHE A 1 711 ? -2.870  52.377  72.287  1.00 84.57  ? 692 PHE A CZ  1 
ATOM   4126 N N   . LEU A 1 712 ? -5.416  53.148  68.500  1.00 82.30  ? 693 LEU A N   1 
ATOM   4127 C CA  . LEU A 1 712 ? -6.526  52.425  69.162  1.00 82.28  ? 693 LEU A CA  1 
ATOM   4128 C C   . LEU A 1 712 ? -7.785  53.275  69.089  1.00 87.38  ? 693 LEU A C   1 
ATOM   4129 O O   . LEU A 1 712 ? -7.662  54.464  69.197  1.00 94.38  ? 693 LEU A O   1 
ATOM   4130 C CB  . LEU A 1 712 ? -6.114  52.189  70.605  1.00 78.34  ? 693 LEU A CB  1 
ATOM   4131 C CG  . LEU A 1 712 ? -7.178  51.532  71.460  1.00 88.08  ? 693 LEU A CG  1 
ATOM   4132 C CD1 . LEU A 1 712 ? -7.758  50.349  70.743  1.00 91.92  ? 693 LEU A CD1 1 
ATOM   4133 C CD2 . LEU A 1 712 ? -6.587  51.093  72.775  1.00 91.23  ? 693 LEU A CD2 1 
ATOM   4134 N N   . PHE A 1 713 ? -8.939  52.676  68.818  1.00 81.96  ? 694 PHE A N   1 
ATOM   4135 C CA  . PHE A 1 713 ? -10.187 53.413  68.622  1.00 87.66  ? 694 PHE A CA  1 
ATOM   4136 C C   . PHE A 1 713 ? -11.268 52.854  69.540  1.00 97.91  ? 694 PHE A C   1 
ATOM   4137 O O   . PHE A 1 713 ? -11.358 51.635  69.716  1.00 97.95  ? 694 PHE A O   1 
ATOM   4138 C CB  . PHE A 1 713 ? -10.668 53.324  67.167  1.00 84.06  ? 694 PHE A CB  1 
ATOM   4139 C CG  . PHE A 1 713 ? -9.863  54.144  66.194  1.00 88.22  ? 694 PHE A CG  1 
ATOM   4140 C CD1 . PHE A 1 713 ? -8.553  53.790  65.866  1.00 85.41  ? 694 PHE A CD1 1 
ATOM   4141 C CD2 . PHE A 1 713 ? -10.435 55.244  65.553  1.00 91.58  ? 694 PHE A CD2 1 
ATOM   4142 C CE1 . PHE A 1 713 ? -7.807  54.549  64.946  1.00 85.49  ? 694 PHE A CE1 1 
ATOM   4143 C CE2 . PHE A 1 713 ? -9.698  56.007  64.623  1.00 90.56  ? 694 PHE A CE2 1 
ATOM   4144 C CZ  . PHE A 1 713 ? -8.384  55.660  64.322  1.00 84.55  ? 694 PHE A CZ  1 
ATOM   4145 N N   . TRP A 1 714 ? -12.100 53.732  70.116  1.00 99.42  ? 695 TRP A N   1 
ATOM   4146 C CA  . TRP A 1 714 ? -13.105 53.326  71.098  1.00 100.61 ? 695 TRP A CA  1 
ATOM   4147 C C   . TRP A 1 714 ? -14.502 53.714  70.619  1.00 104.72 ? 695 TRP A C   1 
ATOM   4148 O O   . TRP A 1 714 ? -14.723 54.851  70.176  1.00 97.81  ? 695 TRP A O   1 
ATOM   4149 C CB  . TRP A 1 714 ? -12.850 53.960  72.478  1.00 102.19 ? 695 TRP A CB  1 
ATOM   4150 C CG  . TRP A 1 714 ? -11.597 53.545  73.280  1.00 98.99  ? 695 TRP A CG  1 
ATOM   4151 C CD1 . TRP A 1 714 ? -10.301 53.918  73.043  1.00 95.10  ? 695 TRP A CD1 1 
ATOM   4152 C CD2 . TRP A 1 714 ? -11.566 52.790  74.505  1.00 97.85  ? 695 TRP A CD2 1 
ATOM   4153 N NE1 . TRP A 1 714 ? -9.462  53.401  74.013  1.00 90.26  ? 695 TRP A NE1 1 
ATOM   4154 C CE2 . TRP A 1 714 ? -10.215 52.707  74.920  1.00 94.49  ? 695 TRP A CE2 1 
ATOM   4155 C CE3 . TRP A 1 714 ? -12.543 52.159  75.276  1.00 98.67  ? 695 TRP A CE3 1 
ATOM   4156 C CZ2 . TRP A 1 714 ? -9.822  52.012  76.061  1.00 95.22  ? 695 TRP A CZ2 1 
ATOM   4157 C CZ3 . TRP A 1 714 ? -12.150 51.470  76.408  1.00 102.31 ? 695 TRP A CZ3 1 
ATOM   4158 C CH2 . TRP A 1 714 ? -10.799 51.397  76.788  1.00 99.47  ? 695 TRP A CH2 1 
ATOM   4159 N N   . ASN A 1 715 ? -15.434 52.753  70.711  1.00 103.54 ? 696 ASN A N   1 
ATOM   4160 C CA  . ASN A 1 715 ? -16.875 52.947  70.539  1.00 112.29 ? 696 ASN A CA  1 
ATOM   4161 C C   . ASN A 1 715 ? -17.510 52.725  71.902  1.00 114.98 ? 696 ASN A C   1 
ATOM   4162 O O   . ASN A 1 715 ? -17.771 51.579  72.287  1.00 116.80 ? 696 ASN A O   1 
ATOM   4163 C CB  . ASN A 1 715 ? -17.485 51.953  69.555  1.00 114.15 ? 696 ASN A CB  1 
ATOM   4164 C CG  . ASN A 1 715 ? -19.027 52.022  69.524  1.00 120.88 ? 696 ASN A CG  1 
ATOM   4165 O OD1 . ASN A 1 715 ? -19.641 53.025  69.926  1.00 126.68 ? 696 ASN A OD1 1 
ATOM   4166 N ND2 . ASN A 1 715 ? -19.651 50.905  69.150  1.00 111.33 ? 696 ASN A ND2 1 
ATOM   4167 N N   . LEU A 1 716 ? -17.805 53.800  72.619  1.00 113.30 ? 697 LEU A N   1 
ATOM   4168 C CA  . LEU A 1 716 ? -18.317 53.622  73.966  1.00 115.33 ? 697 LEU A CA  1 
ATOM   4169 C C   . LEU A 1 716 ? -19.733 54.108  74.153  1.00 115.47 ? 697 LEU A C   1 
ATOM   4170 O O   . LEU A 1 716 ? -20.358 53.756  75.163  1.00 111.72 ? 697 LEU A O   1 
ATOM   4171 C CB  . LEU A 1 716 ? -17.415 54.333  74.982  1.00 108.55 ? 697 LEU A CB  1 
ATOM   4172 C CG  . LEU A 1 716 ? -16.025 53.708  75.018  1.00 108.98 ? 697 LEU A CG  1 
ATOM   4173 C CD1 . LEU A 1 716 ? -15.101 54.473  75.942  1.00 103.36 ? 697 LEU A CD1 1 
ATOM   4174 C CD2 . LEU A 1 716 ? -16.115 52.227  75.405  1.00 108.50 ? 697 LEU A CD2 1 
ATOM   4175 N N   . TYR A 1 717 ? -20.265 54.857  73.201  1.00 118.10 ? 698 TYR A N   1 
ATOM   4176 C CA  . TYR A 1 717 ? -21.322 55.804  73.485  1.00 121.32 ? 698 TYR A CA  1 
ATOM   4177 C C   . TYR A 1 717 ? -22.601 55.432  72.747  1.00 126.21 ? 698 TYR A C   1 
ATOM   4178 O O   . TYR A 1 717 ? -22.569 54.755  71.708  1.00 127.27 ? 698 TYR A O   1 
ATOM   4179 C CB  . TYR A 1 717 ? -20.838 57.223  73.137  1.00 121.05 ? 698 TYR A CB  1 
ATOM   4180 C CG  . TYR A 1 717 ? -19.623 57.632  73.977  1.00 118.99 ? 698 TYR A CG  1 
ATOM   4181 C CD1 . TYR A 1 717 ? -18.372 57.860  73.397  1.00 113.19 ? 698 TYR A CD1 1 
ATOM   4182 C CD2 . TYR A 1 717 ? -19.729 57.752  75.368  1.00 114.12 ? 698 TYR A CD2 1 
ATOM   4183 C CE1 . TYR A 1 717 ? -17.270 58.226  74.183  1.00 108.46 ? 698 TYR A CE1 1 
ATOM   4184 C CE2 . TYR A 1 717 ? -18.642 58.110  76.153  1.00 107.53 ? 698 TYR A CE2 1 
ATOM   4185 C CZ  . TYR A 1 717 ? -17.418 58.346  75.561  1.00 106.97 ? 698 TYR A CZ  1 
ATOM   4186 O OH  . TYR A 1 717 ? -16.352 58.696  76.368  1.00 102.20 ? 698 TYR A OH  1 
ATOM   4187 N N   . LYS A 1 718 ? -23.735 55.835  73.342  1.00 126.87 ? 699 LYS A N   1 
ATOM   4188 C CA  . LYS A 1 718 ? -25.023 55.643  72.684  1.00 134.01 ? 699 LYS A CA  1 
ATOM   4189 C C   . LYS A 1 718 ? -25.041 56.465  71.390  1.00 129.05 ? 699 LYS A C   1 
ATOM   4190 O O   . LYS A 1 718 ? -25.554 56.021  70.361  1.00 128.75 ? 699 LYS A O   1 
ATOM   4191 C CB  . LYS A 1 718 ? -26.177 56.062  73.623  1.00 132.30 ? 699 LYS A CB  1 
ATOM   4192 C CG  . LYS A 1 718 ? -27.631 55.714  73.135  1.00 137.87 ? 699 LYS A CG  1 
ATOM   4193 C CD  . LYS A 1 718 ? -28.036 54.205  73.186  1.00 133.85 ? 699 LYS A CD  1 
ATOM   4194 C CE  . LYS A 1 718 ? -28.340 53.722  74.620  1.00 136.00 ? 699 LYS A CE  1 
ATOM   4195 N NZ  . LYS A 1 718 ? -29.631 54.334  75.100  1.00 130.25 ? 699 LYS A NZ  1 
ATOM   4196 N N   . ALA A 1 719 ? -24.425 57.649  71.417  1.00 123.21 ? 700 ALA A N   1 
ATOM   4197 C CA  . ALA A 1 719 ? -24.188 58.446  70.233  1.00 121.58 ? 700 ALA A CA  1 
ATOM   4198 C C   . ALA A 1 719 ? -23.086 57.819  69.380  1.00 121.09 ? 700 ALA A C   1 
ATOM   4199 O O   . ALA A 1 719 ? -22.371 56.923  69.819  1.00 122.35 ? 700 ALA A O   1 
ATOM   4200 C CB  . ALA A 1 719 ? -23.852 59.883  70.628  1.00 114.62 ? 700 ALA A CB  1 
ATOM   4201 N N   . PRO A 1 720 ? -22.934 58.270  68.149  1.00 117.09 ? 701 PRO A N   1 
ATOM   4202 C CA  . PRO A 1 720 ? -22.029 57.564  67.178  1.00 116.00 ? 701 PRO A CA  1 
ATOM   4203 C C   . PRO A 1 720 ? -20.649 58.218  67.161  1.00 115.36 ? 701 PRO A C   1 
ATOM   4204 O O   . PRO A 1 720 ? -20.275 58.995  66.282  1.00 108.05 ? 701 PRO A O   1 
ATOM   4205 C CB  . PRO A 1 720 ? -22.756 57.779  65.851  1.00 118.00 ? 701 PRO A CB  1 
ATOM   4206 C CG  . PRO A 1 720 ? -23.388 59.090  66.003  1.00 117.16 ? 701 PRO A CG  1 
ATOM   4207 C CD  . PRO A 1 720 ? -23.812 59.231  67.402  1.00 122.29 ? 701 PRO A CD  1 
ATOM   4208 N N   . ILE A 1 721 ? -19.880 57.896  68.188  1.00 114.02 ? 702 ILE A N   1 
ATOM   4209 C CA  . ILE A 1 721 ? -18.594 58.523  68.384  1.00 107.90 ? 702 ILE A CA  1 
ATOM   4210 C C   . ILE A 1 721 ? -17.531 57.470  68.504  1.00 104.63 ? 702 ILE A C   1 
ATOM   4211 O O   . ILE A 1 721 ? -17.656 56.532  69.298  1.00 108.05 ? 702 ILE A O   1 
ATOM   4212 C CB  . ILE A 1 721 ? -18.610 59.506  69.562  1.00 111.73 ? 702 ILE A CB  1 
ATOM   4213 C CG1 . ILE A 1 721 ? -19.439 60.727  69.156  1.00 117.91 ? 702 ILE A CG1 1 
ATOM   4214 C CG2 . ILE A 1 721 ? -17.206 59.828  70.015  1.00 106.92 ? 702 ILE A CG2 1 
ATOM   4215 C CD1 . ILE A 1 721 ? -19.749 61.703  70.228  1.00 112.10 ? 702 ILE A CD1 1 
ATOM   4216 N N   . LEU A 1 722 ? -16.535 57.591  67.641  1.00 101.12 ? 703 LEU A N   1 
ATOM   4217 C CA  . LEU A 1 722 ? -15.304 56.836  67.724  1.00 108.99 ? 703 LEU A CA  1 
ATOM   4218 C C   . LEU A 1 722 ? -14.233 57.754  68.288  1.00 108.29 ? 703 LEU A C   1 
ATOM   4219 O O   . LEU A 1 722 ? -14.181 58.946  67.954  1.00 101.18 ? 703 LEU A O   1 
ATOM   4220 C CB  . LEU A 1 722 ? -14.885 56.306  66.347  1.00 106.05 ? 703 LEU A CB  1 
ATOM   4221 C CG  . LEU A 1 722 ? -15.364 54.894  65.989  1.00 110.30 ? 703 LEU A CG  1 
ATOM   4222 C CD1 . LEU A 1 722 ? -14.573 54.390  64.789  1.00 114.16 ? 703 LEU A CD1 1 
ATOM   4223 C CD2 . LEU A 1 722 ? -15.297 53.895  67.168  1.00 103.43 ? 703 LEU A CD2 1 
ATOM   4224 N N   . LEU A 1 723 ? -13.372 57.182  69.125  1.00 100.66 ? 704 LEU A N   1 
ATOM   4225 C CA  . LEU A 1 723 ? -12.437 57.948  69.923  1.00 94.31  ? 704 LEU A CA  1 
ATOM   4226 C C   . LEU A 1 723 ? -11.046 57.370  69.708  1.00 89.77  ? 704 LEU A C   1 
ATOM   4227 O O   . LEU A 1 723 ? -10.830 56.180  69.950  1.00 93.01  ? 704 LEU A O   1 
ATOM   4228 C CB  . LEU A 1 723 ? -12.890 57.865  71.373  1.00 98.09  ? 704 LEU A CB  1 
ATOM   4229 C CG  . LEU A 1 723 ? -12.406 58.802  72.454  1.00 100.09 ? 704 LEU A CG  1 
ATOM   4230 C CD1 . LEU A 1 723 ? -13.561 58.954  73.422  1.00 102.62 ? 704 LEU A CD1 1 
ATOM   4231 C CD2 . LEU A 1 723 ? -11.225 58.192  73.156  1.00 99.02  ? 704 LEU A CD2 1 
ATOM   4232 N N   . ALA A 1 724 ? -10.114 58.193  69.236  1.00 82.29  ? 705 ALA A N   1 
ATOM   4233 C CA  . ALA A 1 724 ? -8.797  57.737  68.793  1.00 83.31  ? 705 ALA A CA  1 
ATOM   4234 C C   . ALA A 1 724 ? -7.692  58.141  69.768  1.00 92.43  ? 705 ALA A C   1 
ATOM   4235 O O   . ALA A 1 724 ? -7.513  59.338  70.046  1.00 93.07  ? 705 ALA A O   1 
ATOM   4236 C CB  . ALA A 1 724 ? -8.470  58.320  67.415  1.00 85.55  ? 705 ALA A CB  1 
ATOM   4237 N N   . LEU A 1 725 ? -6.902  57.162  70.224  1.00 83.18  ? 706 LEU A N   1 
ATOM   4238 C CA  . LEU A 1 725 ? -5.815  57.410  71.174  1.00 81.10  ? 706 LEU A CA  1 
ATOM   4239 C C   . LEU A 1 725 ? -4.478  57.692  70.498  1.00 82.18  ? 706 LEU A C   1 
ATOM   4240 O O   . LEU A 1 725 ? -4.139  57.077  69.493  1.00 87.46  ? 706 LEU A O   1 
ATOM   4241 C CB  . LEU A 1 725 ? -5.649  56.214  72.107  1.00 82.63  ? 706 LEU A CB  1 
ATOM   4242 C CG  . LEU A 1 725 ? -6.429  56.337  73.413  1.00 93.30  ? 706 LEU A CG  1 
ATOM   4243 C CD1 . LEU A 1 725 ? -7.906  56.349  73.112  1.00 100.57 ? 706 LEU A CD1 1 
ATOM   4244 C CD2 . LEU A 1 725 ? -6.103  55.182  74.345  1.00 85.30  ? 706 LEU A CD2 1 
ATOM   4245 N N   . VAL A 1 726 ? -3.693  58.588  71.090  1.00 79.64  ? 707 VAL A N   1 
ATOM   4246 C CA  . VAL A 1 726 ? -2.338  58.903  70.637  1.00 75.75  ? 707 VAL A CA  1 
ATOM   4247 C C   . VAL A 1 726 ? -1.390  58.672  71.812  1.00 77.20  ? 707 VAL A C   1 
ATOM   4248 O O   . VAL A 1 726 ? -1.318  59.499  72.725  1.00 77.67  ? 707 VAL A O   1 
ATOM   4249 C CB  . VAL A 1 726 ? -2.244  60.340  70.131  1.00 74.84  ? 707 VAL A CB  1 
ATOM   4250 C CG1 . VAL A 1 726 ? -0.848  60.646  69.634  1.00 74.96  ? 707 VAL A CG1 1 
ATOM   4251 C CG2 . VAL A 1 726 ? -3.309  60.579  69.083  1.00 79.83  ? 707 VAL A CG2 1 
ATOM   4252 N N   . ALA A 1 727 ? -0.655  57.559  71.810  1.00 77.42  ? 708 ALA A N   1 
ATOM   4253 C CA  . ALA A 1 727 ? 0.166   57.175  72.955  1.00 78.76  ? 708 ALA A CA  1 
ATOM   4254 C C   . ALA A 1 727 ? 1.634   57.429  72.645  1.00 72.87  ? 708 ALA A C   1 
ATOM   4255 O O   . ALA A 1 727 ? 1.963   58.062  71.647  1.00 76.56  ? 708 ALA A O   1 
ATOM   4256 C CB  . ALA A 1 727 ? -0.082  55.708  73.326  1.00 79.70  ? 708 ALA A CB  1 
ATOM   4257 N N   . GLY A 1 728 ? 2.512   56.936  73.514  1.00 74.08  ? 709 GLY A N   1 
ATOM   4258 C CA  . GLY A 1 728 ? 3.956   56.955  73.351  1.00 72.49  ? 709 GLY A CA  1 
ATOM   4259 C C   . GLY A 1 728 ? 4.470   58.276  72.828  1.00 75.66  ? 709 GLY A C   1 
ATOM   4260 O O   . GLY A 1 728 ? 3.958   59.350  73.131  1.00 87.71  ? 709 GLY A O   1 
ATOM   4261 N N   . GLU A 1 729 ? 5.492   58.185  71.988  1.00 75.28  ? 710 GLU A N   1 
ATOM   4262 C CA  . GLU A 1 729 ? 6.106   59.368  71.392  1.00 70.20  ? 710 GLU A CA  1 
ATOM   4263 C C   . GLU A 1 729 ? 5.130   60.148  70.544  1.00 68.92  ? 710 GLU A C   1 
ATOM   4264 O O   . GLU A 1 729 ? 5.241   61.368  70.429  1.00 80.61  ? 710 GLU A O   1 
ATOM   4265 C CB  . GLU A 1 729 ? 7.256   58.926  70.524  1.00 78.05  ? 710 GLU A CB  1 
ATOM   4266 C CG  . GLU A 1 729 ? 8.092   57.942  71.259  1.00 87.93  ? 710 GLU A CG  1 
ATOM   4267 C CD  . GLU A 1 729 ? 9.064   58.599  72.197  1.00 86.68  ? 710 GLU A CD  1 
ATOM   4268 O OE1 . GLU A 1 729 ? 8.821   59.799  72.501  1.00 88.39  ? 710 GLU A OE1 1 
ATOM   4269 O OE2 . GLU A 1 729 ? 9.938   57.882  72.641  1.00 87.36  ? 710 GLU A OE2 1 
ATOM   4270 N N   . ALA A 1 730 ? 4.198   59.455  69.907  1.00 73.03  ? 711 ALA A N   1 
ATOM   4271 C CA  . ALA A 1 730 ? 3.233   60.127  69.057  1.00 81.82  ? 711 ALA A CA  1 
ATOM   4272 C C   . ALA A 1 730 ? 2.555   61.269  69.811  1.00 83.10  ? 711 ALA A C   1 
ATOM   4273 O O   . ALA A 1 730 ? 2.383   62.372  69.271  1.00 81.03  ? 711 ALA A O   1 
ATOM   4274 C CB  . ALA A 1 730 ? 2.230   59.093  68.542  1.00 79.84  ? 711 ALA A CB  1 
ATOM   4275 N N   . ALA A 1 731 ? 2.252   61.039  71.093  1.00 82.21  ? 712 ALA A N   1 
ATOM   4276 C CA  . ALA A 1 731 ? 1.515   62.003  71.900  1.00 81.51  ? 712 ALA A CA  1 
ATOM   4277 C C   . ALA A 1 731 ? 2.163   63.371  71.853  1.00 82.67  ? 712 ALA A C   1 
ATOM   4278 O O   . ALA A 1 731 ? 1.534   64.359  71.457  1.00 81.08  ? 712 ALA A O   1 
ATOM   4279 C CB  . ALA A 1 731 ? 1.424   61.514  73.343  1.00 75.88  ? 712 ALA A CB  1 
ATOM   4280 N N   . GLY A 1 732 ? 3.435   63.440  72.255  1.00 82.21  ? 713 GLY A N   1 
ATOM   4281 C CA  . GLY A 1 732 ? 4.108   64.722  72.306  1.00 85.00  ? 713 GLY A CA  1 
ATOM   4282 C C   . GLY A 1 732 ? 4.230   65.377  70.950  1.00 87.31  ? 713 GLY A C   1 
ATOM   4283 O O   . GLY A 1 732 ? 4.234   66.608  70.851  1.00 89.98  ? 713 GLY A O   1 
ATOM   4284 N N   . ILE A 1 733 ? 4.301   64.565  69.890  1.00 90.17  ? 714 ILE A N   1 
ATOM   4285 C CA  . ILE A 1 733 ? 4.513   65.081  68.539  1.00 85.84  ? 714 ILE A CA  1 
ATOM   4286 C C   . ILE A 1 733 ? 3.227   65.630  67.953  1.00 79.96  ? 714 ILE A C   1 
ATOM   4287 O O   . ILE A 1 733 ? 3.208   66.714  67.373  1.00 84.17  ? 714 ILE A O   1 
ATOM   4288 C CB  . ILE A 1 733 ? 5.075   63.986  67.629  1.00 84.63  ? 714 ILE A CB  1 
ATOM   4289 C CG1 . ILE A 1 733 ? 6.444   63.543  68.111  1.00 75.37  ? 714 ILE A CG1 1 
ATOM   4290 C CG2 . ILE A 1 733 ? 5.166   64.542  66.227  1.00 91.54  ? 714 ILE A CG2 1 
ATOM   4291 C CD1 . ILE A 1 733 ? 7.331   64.675  68.110  1.00 83.14  ? 714 ILE A CD1 1 
ATOM   4292 N N   . MET A 1 734 ? 2.146   64.869  68.059  1.00 80.16  ? 715 MET A N   1 
ATOM   4293 C CA  . MET A 1 734 ? 0.891   65.272  67.454  1.00 83.53  ? 715 MET A CA  1 
ATOM   4294 C C   . MET A 1 734 ? 0.341   66.559  68.038  1.00 92.79  ? 715 MET A C   1 
ATOM   4295 O O   . MET A 1 734 ? -0.586  67.137  67.456  1.00 98.63  ? 715 MET A O   1 
ATOM   4296 C CB  . MET A 1 734 ? -0.128  64.140  67.591  1.00 92.13  ? 715 MET A CB  1 
ATOM   4297 C CG  . MET A 1 734 ? 0.358   62.855  66.907  1.00 97.86  ? 715 MET A CG  1 
ATOM   4298 S SD  . MET A 1 734 ? -0.008  62.833  65.136  1.00 115.65 ? 715 MET A SD  1 
ATOM   4299 C CE  . MET A 1 734 ? 1.664   62.900  64.455  1.00 102.90 ? 715 MET A CE  1 
ATOM   4300 N N   . GLU A 1 735 ? 0.890   67.045  69.153  1.00 93.68  ? 716 GLU A N   1 
ATOM   4301 C CA  . GLU A 1 735 ? 0.410   68.315  69.672  1.00 89.68  ? 716 GLU A CA  1 
ATOM   4302 C C   . GLU A 1 735 ? 0.936   69.500  68.878  1.00 90.14  ? 716 GLU A C   1 
ATOM   4303 O O   . GLU A 1 735 ? 0.321   70.565  68.921  1.00 93.31  ? 716 GLU A O   1 
ATOM   4304 C CB  . GLU A 1 735 ? 0.770   68.467  71.143  1.00 85.25  ? 716 GLU A CB  1 
ATOM   4305 C CG  . GLU A 1 735 ? -0.174  67.700  72.058  1.00 90.37  ? 716 GLU A CG  1 
ATOM   4306 C CD  . GLU A 1 735 ? 0.093   67.950  73.552  1.00 91.93  ? 716 GLU A CD  1 
ATOM   4307 O OE1 . GLU A 1 735 ? 0.855   68.910  73.876  1.00 91.18  ? 716 GLU A OE1 1 
ATOM   4308 O OE2 . GLU A 1 735 ? -0.426  67.156  74.395  1.00 82.88  ? 716 GLU A OE2 1 
ATOM   4309 N N   . ASN A 1 736 ? 2.042   69.330  68.148  1.00 91.83  ? 717 ASN A N   1 
ATOM   4310 C CA  . ASN A 1 736 ? 2.568   70.314  67.205  1.00 96.71  ? 717 ASN A CA  1 
ATOM   4311 C C   . ASN A 1 736 ? 1.910   70.259  65.835  1.00 98.44  ? 717 ASN A C   1 
ATOM   4312 O O   . ASN A 1 736 ? 2.389   70.926  64.920  1.00 106.64 ? 717 ASN A O   1 
ATOM   4313 C CB  . ASN A 1 736 ? 4.064   70.111  67.005  1.00 100.41 ? 717 ASN A CB  1 
ATOM   4314 C CG  . ASN A 1 736 ? 4.859   70.607  68.156  1.00 103.81 ? 717 ASN A CG  1 
ATOM   4315 O OD1 . ASN A 1 736 ? 4.512   71.620  68.768  1.00 102.40 ? 717 ASN A OD1 1 
ATOM   4316 N ND2 . ASN A 1 736 ? 5.934   69.890  68.483  1.00 104.81 ? 717 ASN A ND2 1 
ATOM   4317 N N   . ILE A 1 737 ? 0.854   69.483  65.658  1.00 93.82  ? 718 ILE A N   1 
ATOM   4318 C CA  . ILE A 1 737 ? 0.230   69.308  64.358  1.00 100.46 ? 718 ILE A CA  1 
ATOM   4319 C C   . ILE A 1 737 ? -1.242  69.689  64.482  1.00 102.70 ? 718 ILE A C   1 
ATOM   4320 O O   . ILE A 1 737 ? -1.852  69.505  65.539  1.00 105.32 ? 718 ILE A O   1 
ATOM   4321 C CB  . ILE A 1 737 ? 0.456   67.852  63.876  1.00 100.09 ? 718 ILE A CB  1 
ATOM   4322 C CG1 . ILE A 1 737 ? 1.848   67.743  63.231  1.00 102.64 ? 718 ILE A CG1 1 
ATOM   4323 C CG2 . ILE A 1 737 ? -0.664  67.352  62.973  1.00 94.10  ? 718 ILE A CG2 1 
ATOM   4324 C CD1 . ILE A 1 737 ? 2.439   66.336  63.235  1.00 102.42 ? 718 ILE A CD1 1 
ATOM   4325 N N   . SER A 1 738 ? -1.797  70.257  63.406  1.00 106.16 ? 719 SER A N   1 
ATOM   4326 C CA  . SER A 1 738 ? -3.147  70.817  63.379  1.00 103.75 ? 719 SER A CA  1 
ATOM   4327 C C   . SER A 1 738 ? -4.218  69.769  63.649  1.00 106.54 ? 719 SER A C   1 
ATOM   4328 O O   . SER A 1 738 ? -4.013  68.565  63.457  1.00 103.69 ? 719 SER A O   1 
ATOM   4329 C CB  . SER A 1 738 ? -3.464  71.413  62.013  1.00 114.50 ? 719 SER A CB  1 
ATOM   4330 O OG  . SER A 1 738 ? -4.781  71.919  61.954  1.00 121.52 ? 719 SER A OG  1 
ATOM   4331 N N   . ASP A 1 739 ? -5.403  70.259  64.035  1.00 108.36 ? 720 ASP A N   1 
ATOM   4332 C CA  . ASP A 1 739 ? -6.553  69.376  64.208  1.00 106.52 ? 720 ASP A CA  1 
ATOM   4333 C C   . ASP A 1 739 ? -6.926  68.734  62.881  1.00 114.16 ? 720 ASP A C   1 
ATOM   4334 O O   . ASP A 1 739 ? -7.156  67.519  62.801  1.00 110.36 ? 720 ASP A O   1 
ATOM   4335 C CB  . ASP A 1 739 ? -7.761  70.142  64.772  1.00 114.24 ? 720 ASP A CB  1 
ATOM   4336 C CG  . ASP A 1 739 ? -7.486  70.806  66.134  1.00 119.96 ? 720 ASP A CG  1 
ATOM   4337 O OD1 . ASP A 1 739 ? -8.443  71.373  66.718  1.00 121.25 ? 720 ASP A OD1 1 
ATOM   4338 O OD2 . ASP A 1 739 ? -6.326  70.779  66.614  1.00 120.81 ? 720 ASP A OD2 1 
ATOM   4339 N N   . ASP A 1 740 ? -6.972  69.543  61.817  1.00 118.61 ? 721 ASP A N   1 
ATOM   4340 C CA  . ASP A 1 740 ? -7.308  69.027  60.494  1.00 113.32 ? 721 ASP A CA  1 
ATOM   4341 C C   . ASP A 1 740 ? -6.327  67.945  60.066  1.00 109.26 ? 721 ASP A C   1 
ATOM   4342 O O   . ASP A 1 740 ? -6.731  66.816  59.763  1.00 108.56 ? 721 ASP A O   1 
ATOM   4343 C CB  . ASP A 1 740 ? -7.350  70.172  59.491  1.00 114.51 ? 721 ASP A CB  1 
ATOM   4344 C CG  . ASP A 1 740 ? -8.336  71.247  59.900  1.00 129.45 ? 721 ASP A CG  1 
ATOM   4345 O OD1 . ASP A 1 740 ? -9.448  70.886  60.355  1.00 129.51 ? 721 ASP A OD1 1 
ATOM   4346 O OD2 . ASP A 1 740 ? -7.998  72.449  59.780  1.00 136.81 ? 721 ASP A OD2 1 
ATOM   4347 N N   . VAL A 1 741 ? -5.041  68.263  60.084  1.00 98.92  ? 722 VAL A N   1 
ATOM   4348 C CA  . VAL A 1 741 ? -4.019  67.259  59.687  1.00 97.18  ? 722 VAL A CA  1 
ATOM   4349 C C   . VAL A 1 741 ? -4.190  66.025  60.561  1.00 104.60 ? 722 VAL A C   1 
ATOM   4350 O O   . VAL A 1 741 ? -4.266  64.937  60.030  1.00 103.59 ? 722 VAL A O   1 
ATOM   4351 C CB  . VAL A 1 741 ? -2.622  67.846  59.872  1.00 97.62  ? 722 VAL A CB  1 
ATOM   4352 C CG1 . VAL A 1 741 ? -1.638  67.250  58.895  1.00 99.71  ? 722 VAL A CG1 1 
ATOM   4353 C CG2 . VAL A 1 741 ? -2.661  69.349  59.743  1.00 105.10 ? 722 VAL A CG2 1 
ATOM   4354 N N   . ILE A 1 742 ? -4.426  66.232  61.844  1.00 105.40 ? 723 ILE A N   1 
ATOM   4355 C CA  . ILE A 1 742 ? -4.582  65.053  62.732  1.00 102.74 ? 723 ILE A CA  1 
ATOM   4356 C C   . ILE A 1 742 ? -5.871  64.367  62.347  1.00 104.42 ? 723 ILE A C   1 
ATOM   4357 O O   . ILE A 1 742 ? -5.893  63.166  62.225  1.00 104.41 ? 723 ILE A O   1 
ATOM   4358 C CB  . ILE A 1 742 ? -4.653  65.471  64.200  1.00 102.78 ? 723 ILE A CB  1 
ATOM   4359 C CG1 . ILE A 1 742 ? -3.265  65.735  64.767  1.00 100.98 ? 723 ILE A CG1 1 
ATOM   4360 C CG2 . ILE A 1 742 ? -5.370  64.400  64.986  1.00 94.58  ? 723 ILE A CG2 1 
ATOM   4361 C CD1 . ILE A 1 742 ? -3.289  66.213  66.182  1.00 99.40  ? 723 ILE A CD1 1 
ATOM   4362 N N   . VAL A 1 743 ? -6.906  65.142  62.106  1.00 103.70 ? 724 VAL A N   1 
ATOM   4363 C CA  . VAL A 1 743 ? -8.193  64.479  61.782  1.00 115.59 ? 724 VAL A CA  1 
ATOM   4364 C C   . VAL A 1 743 ? -8.047  63.720  60.464  1.00 115.22 ? 724 VAL A C   1 
ATOM   4365 O O   . VAL A 1 743 ? -8.561  62.606  60.377  1.00 109.11 ? 724 VAL A O   1 
ATOM   4366 C CB  . VAL A 1 743 ? -9.338  65.499  61.773  1.00 114.54 ? 724 VAL A CB  1 
ATOM   4367 C CG1 . VAL A 1 743 ? -10.591 64.903  62.376  1.00 113.35 ? 724 VAL A CG1 1 
ATOM   4368 C CG2 . VAL A 1 743 ? -8.943  66.759  62.520  1.00 97.45  ? 724 VAL A CG2 1 
ATOM   4369 N N   . GLY A 1 744 ? -7.353  64.303  59.488  1.00 111.50 ? 725 GLY A N   1 
ATOM   4370 C CA  . GLY A 1 744 ? -7.120  63.650  58.191  1.00 100.05 ? 725 GLY A CA  1 
ATOM   4371 C C   . GLY A 1 744 ? -6.583  62.258  58.393  1.00 102.48 ? 725 GLY A C   1 
ATOM   4372 O O   . GLY A 1 744 ? -7.213  61.321  57.935  1.00 104.60 ? 725 GLY A O   1 
ATOM   4373 N N   . ARG A 1 745 ? -5.444  62.156  59.061  1.00 97.47  ? 726 ARG A N   1 
ATOM   4374 C CA  . ARG A 1 745 ? -4.825  60.835  59.282  1.00 93.92  ? 726 ARG A CA  1 
ATOM   4375 C C   . ARG A 1 745 ? -5.831  59.928  59.965  1.00 96.01  ? 726 ARG A C   1 
ATOM   4376 O O   . ARG A 1 745 ? -5.676  58.731  59.903  1.00 95.03  ? 726 ARG A O   1 
ATOM   4377 C CB  . ARG A 1 745 ? -3.592  60.986  60.162  1.00 91.61  ? 726 ARG A CB  1 
ATOM   4378 C CG  . ARG A 1 745 ? -2.635  62.061  59.689  1.00 91.46  ? 726 ARG A CG  1 
ATOM   4379 C CD  . ARG A 1 745 ? -1.372  61.857  60.471  1.00 94.29  ? 726 ARG A CD  1 
ATOM   4380 N NE  . ARG A 1 745 ? -0.444  62.940  60.263  1.00 100.26 ? 726 ARG A NE  1 
ATOM   4381 C CZ  . ARG A 1 745 ? 0.789   62.926  60.718  1.00 106.97 ? 726 ARG A CZ  1 
ATOM   4382 N NH1 . ARG A 1 745 ? 1.216   61.888  61.407  1.00 108.59 ? 726 ARG A NH1 1 
ATOM   4383 N NH2 . ARG A 1 745 ? 1.594   63.940  60.492  1.00 101.99 ? 726 ARG A NH2 1 
ATOM   4384 N N   . CYS A 1 746 ? -6.855  60.510  60.555  1.00 102.14 ? 727 CYS A N   1 
ATOM   4385 C CA  . CYS A 1 746 ? -7.841  59.665  61.257  1.00 108.08 ? 727 CYS A CA  1 
ATOM   4386 C C   . CYS A 1 746 ? -8.763  59.052  60.228  1.00 103.35 ? 727 CYS A C   1 
ATOM   4387 O O   . CYS A 1 746 ? -8.980  57.858  60.251  1.00 105.32 ? 727 CYS A O   1 
ATOM   4388 C CB  . CYS A 1 746 ? -8.726  60.531  62.126  1.00 113.62 ? 727 CYS A CB  1 
ATOM   4389 S SG  . CYS A 1 746 ? -8.178  60.514  63.840  1.00 116.46 ? 727 CYS A SG  1 
ATOM   4390 N N   . LEU A 1 747 ? -9.282  59.899  59.360  1.00 106.81 ? 728 LEU A N   1 
ATOM   4391 C CA  . LEU A 1 747 ? -10.212 59.427  58.320  1.00 108.01 ? 728 LEU A CA  1 
ATOM   4392 C C   . LEU A 1 747 ? -9.502  58.360  57.510  1.00 105.44 ? 728 LEU A C   1 
ATOM   4393 O O   . LEU A 1 747 ? -10.064 57.283  57.370  1.00 102.75 ? 728 LEU A O   1 
ATOM   4394 C CB  . LEU A 1 747 ? -10.560 60.643  57.474  1.00 108.76 ? 728 LEU A CB  1 
ATOM   4395 C CG  . LEU A 1 747 ? -11.247 61.739  58.274  1.00 113.51 ? 728 LEU A CG  1 
ATOM   4396 C CD1 . LEU A 1 747 ? -11.773 62.835  57.366  1.00 112.82 ? 728 LEU A CD1 1 
ATOM   4397 C CD2 . LEU A 1 747 ? -12.371 61.141  59.096  1.00 107.51 ? 728 LEU A CD2 1 
ATOM   4398 N N   . ALA A 1 748 ? -8.305  58.692  57.044  1.00 104.96 ? 729 ALA A N   1 
ATOM   4399 C CA  . ALA A 1 748 ? -7.443  57.800  56.247  1.00 103.14 ? 729 ALA A CA  1 
ATOM   4400 C C   . ALA A 1 748 ? -7.450  56.411  56.854  1.00 103.56 ? 729 ALA A C   1 
ATOM   4401 O O   . ALA A 1 748 ? -7.914  55.486  56.212  1.00 108.97 ? 729 ALA A O   1 
ATOM   4402 C CB  . ALA A 1 748 ? -6.050  58.349  56.268  1.00 96.58  ? 729 ALA A CB  1 
ATOM   4403 N N   . ILE A 1 749 ? -7.050  56.316  58.106  1.00 100.90 ? 730 ILE A N   1 
ATOM   4404 C CA  . ILE A 1 749 ? -6.983  54.990  58.759  1.00 101.82 ? 730 ILE A CA  1 
ATOM   4405 C C   . ILE A 1 749 ? -8.368  54.379  58.771  1.00 105.00 ? 730 ILE A C   1 
ATOM   4406 O O   . ILE A 1 749 ? -8.504  53.229  58.404  1.00 107.74 ? 730 ILE A O   1 
ATOM   4407 C CB  . ILE A 1 749 ? -6.429  55.157  60.172  1.00 103.76 ? 730 ILE A CB  1 
ATOM   4408 C CG1 . ILE A 1 749 ? -4.923  55.382  60.109  1.00 99.19  ? 730 ILE A CG1 1 
ATOM   4409 C CG2 . ILE A 1 749 ? -6.783  53.954  61.008  1.00 100.08 ? 730 ILE A CG2 1 
ATOM   4410 C CD1 . ILE A 1 749 ? -4.316  55.807  61.397  1.00 97.56  ? 730 ILE A CD1 1 
ATOM   4411 N N   . LEU A 1 750 ? -9.344  55.174  59.151  1.00 106.30 ? 731 LEU A N   1 
ATOM   4412 C CA  . LEU A 1 750 ? -10.714 54.640  59.194  1.00 114.21 ? 731 LEU A CA  1 
ATOM   4413 C C   . LEU A 1 750 ? -11.080 54.220  57.778  1.00 119.92 ? 731 LEU A C   1 
ATOM   4414 O O   . LEU A 1 750 ? -11.631 53.124  57.609  1.00 119.32 ? 731 LEU A O   1 
ATOM   4415 C CB  . LEU A 1 750 ? -11.624 55.757  59.693  1.00 114.65 ? 731 LEU A CB  1 
ATOM   4416 C CG  . LEU A 1 750 ? -11.554 56.009  61.191  1.00 106.11 ? 731 LEU A CG  1 
ATOM   4417 C CD1 . LEU A 1 750 ? -12.756 56.800  61.641  1.00 109.28 ? 731 LEU A CD1 1 
ATOM   4418 C CD2 . LEU A 1 750 ? -11.499 54.700  61.944  1.00 101.33 ? 731 LEU A CD2 1 
ATOM   4419 N N   . LYS A 1 751 ? -10.755 55.075  56.812  1.00 116.12 ? 732 LYS A N   1 
ATOM   4420 C CA  . LYS A 1 751 ? -11.069 54.765  55.400  1.00 115.65 ? 732 LYS A CA  1 
ATOM   4421 C C   . LYS A 1 751 ? -10.424 53.426  55.070  1.00 115.14 ? 732 LYS A C   1 
ATOM   4422 O O   . LYS A 1 751 ? -11.125 52.544  54.675  1.00 113.69 ? 732 LYS A O   1 
ATOM   4423 C CB  . LYS A 1 751 ? -10.532 55.858  54.479  1.00 113.03 ? 732 LYS A CB  1 
ATOM   4424 C CG  . LYS A 1 751 ? -11.485 57.005  54.181  1.00 109.02 ? 732 LYS A CG  1 
ATOM   4425 C CD  . LYS A 1 751 ? -10.851 58.022  53.264  1.00 108.93 ? 732 LYS A CD  1 
ATOM   4426 C CE  . LYS A 1 751 ? -11.456 59.405  53.348  1.00 109.79 ? 732 LYS A CE  1 
ATOM   4427 N NZ  . LYS A 1 751 ? -10.558 60.422  52.753  1.00 113.64 ? 732 LYS A NZ  1 
ATOM   4428 N N   . GLY A 1 752 ? -9.138  53.278  55.332  1.00 109.09 ? 733 GLY A N   1 
ATOM   4429 C CA  . GLY A 1 752 ? -8.458  52.010  55.023  1.00 116.62 ? 733 GLY A CA  1 
ATOM   4430 C C   . GLY A 1 752 ? -9.129  50.802  55.640  1.00 115.10 ? 733 GLY A C   1 
ATOM   4431 O O   . GLY A 1 752 ? -9.290  49.821  54.944  1.00 123.66 ? 733 GLY A O   1 
ATOM   4432 N N   . ILE A 1 753 ? -9.573  50.879  56.886  1.00 111.20 ? 734 ILE A N   1 
ATOM   4433 C CA  . ILE A 1 753 ? -10.169 49.662  57.502  1.00 117.62 ? 734 ILE A CA  1 
ATOM   4434 C C   . ILE A 1 753 ? -11.631 49.516  57.089  1.00 117.27 ? 734 ILE A C   1 
ATOM   4435 O O   . ILE A 1 753 ? -12.170 48.435  57.279  1.00 117.05 ? 734 ILE A O   1 
ATOM   4436 C CB  . ILE A 1 753 ? -10.008 49.671  59.034  1.00 117.33 ? 734 ILE A CB  1 
ATOM   4437 C CG1 . ILE A 1 753 ? -8.609  49.240  59.465  1.00 116.49 ? 734 ILE A CG1 1 
ATOM   4438 C CG2 . ILE A 1 753 ? -11.049 48.792  59.694  1.00 105.81 ? 734 ILE A CG2 1 
ATOM   4439 C CD1 . ILE A 1 753 ? -7.541  50.266  59.202  1.00 110.46 ? 734 ILE A CD1 1 
ATOM   4440 N N   . PHE A 1 754 ? -12.245 50.527  56.487  1.00 116.00 ? 735 PHE A N   1 
ATOM   4441 C CA  . PHE A 1 754 ? -13.685 50.316  56.214  1.00 122.32 ? 735 PHE A CA  1 
ATOM   4442 C C   . PHE A 1 754 ? -14.059 50.631  54.770  1.00 120.32 ? 735 PHE A C   1 
ATOM   4443 O O   . PHE A 1 754 ? -15.216 50.427  54.413  1.00 116.18 ? 735 PHE A O   1 
ATOM   4444 C CB  . PHE A 1 754 ? -14.509 51.206  57.137  1.00 123.16 ? 735 PHE A CB  1 
ATOM   4445 C CG  . PHE A 1 754 ? -14.554 50.764  58.572  1.00 118.34 ? 735 PHE A CG  1 
ATOM   4446 C CD1 . PHE A 1 754 ? -15.596 49.990  59.039  1.00 120.43 ? 735 PHE A CD1 1 
ATOM   4447 C CD2 . PHE A 1 754 ? -13.565 51.133  59.456  1.00 114.32 ? 735 PHE A CD2 1 
ATOM   4448 C CE1 . PHE A 1 754 ? -15.645 49.584  60.358  1.00 122.24 ? 735 PHE A CE1 1 
ATOM   4449 C CE2 . PHE A 1 754 ? -13.620 50.729  60.776  1.00 116.51 ? 735 PHE A CE2 1 
ATOM   4450 C CZ  . PHE A 1 754 ? -14.652 49.950  61.223  1.00 116.93 ? 735 PHE A CZ  1 
ATOM   4451 N N   . GLY A 1 755 ? -13.116 51.143  53.993  1.00 115.79 ? 736 GLY A N   1 
ATOM   4452 C CA  . GLY A 1 755 ? -13.340 51.517  52.586  1.00 117.81 ? 736 GLY A CA  1 
ATOM   4453 C C   . GLY A 1 755 ? -13.718 52.974  52.468  1.00 117.61 ? 736 GLY A C   1 
ATOM   4454 O O   . GLY A 1 755 ? -14.643 53.357  53.182  1.00 120.57 ? 736 GLY A O   1 
ATOM   4455 N N   . SER A 1 756 ? -13.015 53.725  51.609  1.00 115.30 ? 737 SER A N   1 
ATOM   4456 C CA  . SER A 1 756 ? -13.267 55.165  51.384  1.00 113.12 ? 737 SER A CA  1 
ATOM   4457 C C   . SER A 1 756 ? -14.760 55.483  51.376  1.00 116.80 ? 737 SER A C   1 
ATOM   4458 O O   . SER A 1 756 ? -15.150 56.558  51.815  1.00 120.30 ? 737 SER A O   1 
ATOM   4459 C CB  . SER A 1 756 ? -12.605 55.598  50.119  1.00 112.39 ? 737 SER A CB  1 
ATOM   4460 O OG  . SER A 1 756 ? -12.823 56.975  49.888  1.00 109.77 ? 737 SER A OG  1 
ATOM   4461 N N   . SER A 1 757 ? -15.558 54.528  50.944  1.00 116.79 ? 738 SER A N   1 
ATOM   4462 C CA  . SER A 1 757 ? -17.002 54.798  50.791  1.00 120.25 ? 738 SER A CA  1 
ATOM   4463 C C   . SER A 1 757 ? -17.674 55.121  52.121  1.00 120.08 ? 738 SER A C   1 
ATOM   4464 O O   . SER A 1 757 ? -18.201 56.217  52.244  1.00 118.90 ? 738 SER A O   1 
ATOM   4465 C CB  . SER A 1 757 ? -17.678 53.647  50.116  1.00 125.06 ? 738 SER A CB  1 
ATOM   4466 O OG  . SER A 1 757 ? -18.236 52.769  51.075  1.00 123.07 ? 738 SER A OG  1 
ATOM   4467 N N   . ALA A 1 758 ? -17.586 54.218  53.094  1.00 121.42 ? 739 ALA A N   1 
ATOM   4468 C CA  . ALA A 1 758 ? -18.352 54.350  54.357  1.00 125.01 ? 739 ALA A CA  1 
ATOM   4469 C C   . ALA A 1 758 ? -17.754 55.296  55.404  1.00 126.73 ? 739 ALA A C   1 
ATOM   4470 O O   . ALA A 1 758 ? -18.184 55.206  56.547  1.00 125.28 ? 739 ALA A O   1 
ATOM   4471 C CB  . ALA A 1 758 ? -18.568 52.984  54.943  1.00 118.91 ? 739 ALA A CB  1 
ATOM   4472 N N   . VAL A 1 759 ? -16.825 56.176  55.052  1.00 127.49 ? 740 VAL A N   1 
ATOM   4473 C CA  . VAL A 1 759 ? -16.281 57.097  56.085  1.00 125.20 ? 740 VAL A CA  1 
ATOM   4474 C C   . VAL A 1 759 ? -16.788 58.502  55.791  1.00 121.11 ? 740 VAL A C   1 
ATOM   4475 O O   . VAL A 1 759 ? -16.177 59.213  55.002  1.00 113.34 ? 740 VAL A O   1 
ATOM   4476 C CB  . VAL A 1 759 ? -14.749 57.040  56.153  1.00 125.79 ? 740 VAL A CB  1 
ATOM   4477 C CG1 . VAL A 1 759 ? -14.095 57.509  54.866  1.00 122.77 ? 740 VAL A CG1 1 
ATOM   4478 C CG2 . VAL A 1 759 ? -14.248 57.847  57.323  1.00 122.81 ? 740 VAL A CG2 1 
ATOM   4479 N N   . PRO A 1 760 ? -17.850 58.955  56.474  1.00 121.22 ? 741 PRO A N   1 
ATOM   4480 C CA  . PRO A 1 760 ? -18.438 60.260  56.228  1.00 123.28 ? 741 PRO A CA  1 
ATOM   4481 C C   . PRO A 1 760 ? -17.572 61.354  56.833  1.00 118.79 ? 741 PRO A C   1 
ATOM   4482 O O   . PRO A 1 760 ? -16.847 61.059  57.710  1.00 124.38 ? 741 PRO A O   1 
ATOM   4483 C CB  . PRO A 1 760 ? -19.670 60.268  57.130  1.00 117.28 ? 741 PRO A CB  1 
ATOM   4484 C CG  . PRO A 1 760 ? -19.896 58.830  57.465  1.00 120.93 ? 741 PRO A CG  1 
ATOM   4485 C CD  . PRO A 1 760 ? -18.509 58.246  57.542  1.00 120.12 ? 741 PRO A CD  1 
ATOM   4486 N N   . GLN A 1 761 ? -17.726 62.598  56.407  1.00 112.50 ? 742 GLN A N   1 
ATOM   4487 C CA  . GLN A 1 761 ? -16.903 63.617  57.087  1.00 118.80 ? 742 GLN A CA  1 
ATOM   4488 C C   . GLN A 1 761 ? -17.382 63.720  58.531  1.00 128.32 ? 742 GLN A C   1 
ATOM   4489 O O   . GLN A 1 761 ? -18.588 63.705  58.762  1.00 128.04 ? 742 GLN A O   1 
ATOM   4490 C CB  . GLN A 1 761 ? -16.959 64.968  56.395  1.00 112.59 ? 742 GLN A CB  1 
ATOM   4491 C CG  . GLN A 1 761 ? -15.639 65.701  56.493  1.00 115.12 ? 742 GLN A CG  1 
ATOM   4492 C CD  . GLN A 1 761 ? -14.544 64.893  55.851  1.00 120.65 ? 742 GLN A CD  1 
ATOM   4493 O OE1 . GLN A 1 761 ? -14.731 63.737  55.498  1.00 117.20 ? 742 GLN A OE1 1 
ATOM   4494 N NE2 . GLN A 1 761 ? -13.386 65.504  55.688  1.00 119.20 ? 742 GLN A NE2 1 
ATOM   4495 N N   . PRO A 1 762 ? -16.476 63.811  59.514  1.00 124.63 ? 743 PRO A N   1 
ATOM   4496 C CA  . PRO A 1 762 ? -16.878 63.902  60.901  1.00 118.09 ? 743 PRO A CA  1 
ATOM   4497 C C   . PRO A 1 762 ? -17.596 65.234  61.101  1.00 117.13 ? 743 PRO A C   1 
ATOM   4498 O O   . PRO A 1 762 ? -17.148 66.216  60.592  1.00 111.31 ? 743 PRO A O   1 
ATOM   4499 C CB  . PRO A 1 762 ? -15.532 63.974  61.605  1.00 118.54 ? 743 PRO A CB  1 
ATOM   4500 C CG  . PRO A 1 762 ? -14.636 64.582  60.576  1.00 116.05 ? 743 PRO A CG  1 
ATOM   4501 C CD  . PRO A 1 762 ? -15.043 63.869  59.317  1.00 117.44 ? 743 PRO A CD  1 
ATOM   4502 N N   . LYS A 1 763 ? -18.684 65.215  61.854  1.00 115.85 ? 744 LYS A N   1 
ATOM   4503 C CA  . LYS A 1 763 ? -19.460 66.451  62.080  1.00 117.03 ? 744 LYS A CA  1 
ATOM   4504 C C   . LYS A 1 763 ? -18.707 67.358  63.051  1.00 119.98 ? 744 LYS A C   1 
ATOM   4505 O O   . LYS A 1 763 ? -18.583 68.547  62.771  1.00 113.47 ? 744 LYS A O   1 
ATOM   4506 C CB  . LYS A 1 763 ? -20.817 66.084  62.665  1.00 113.48 ? 744 LYS A CB  1 
ATOM   4507 C CG  . LYS A 1 763 ? -21.404 67.138  63.582  1.00 126.56 ? 744 LYS A CG  1 
ATOM   4508 C CD  . LYS A 1 763 ? -21.301 68.539  63.026  1.00 133.37 ? 744 LYS A CD  1 
ATOM   4509 C CE  . LYS A 1 763 ? -22.492 69.411  63.366  1.00 133.43 ? 744 LYS A CE  1 
ATOM   4510 N NZ  . LYS A 1 763 ? -22.650 70.516  62.391  1.00 129.83 ? 744 LYS A NZ  1 
ATOM   4511 N N   . GLU A 1 764 ? -18.227 66.797  64.158  1.00 124.91 ? 745 GLU A N   1 
ATOM   4512 C CA  . GLU A 1 764 ? -17.508 67.589  65.180  1.00 117.73 ? 745 GLU A CA  1 
ATOM   4513 C C   . GLU A 1 764 ? -16.193 66.900  65.525  1.00 111.61 ? 745 GLU A C   1 
ATOM   4514 O O   . GLU A 1 764 ? -16.215 65.708  65.772  1.00 104.55 ? 745 GLU A O   1 
ATOM   4515 C CB  . GLU A 1 764 ? -18.368 67.656  66.432  1.00 118.47 ? 745 GLU A CB  1 
ATOM   4516 C CG  . GLU A 1 764 ? -19.567 68.552  66.264  1.00 117.08 ? 745 GLU A CG  1 
ATOM   4517 C CD  . GLU A 1 764 ? -19.186 70.012  66.267  1.00 120.77 ? 745 GLU A CD  1 
ATOM   4518 O OE1 . GLU A 1 764 ? -18.072 70.311  66.694  1.00 120.93 ? 745 GLU A OE1 1 
ATOM   4519 O OE2 . GLU A 1 764 ? -19.998 70.833  65.841  1.00 124.49 ? 745 GLU A OE2 1 
ATOM   4520 N N   . THR A 1 765 ? -15.108 67.663  65.549  1.00 108.54 ? 746 THR A N   1 
ATOM   4521 C CA  . THR A 1 765 ? -13.792 67.140  65.859  1.00 102.53 ? 746 THR A CA  1 
ATOM   4522 C C   . THR A 1 765 ? -13.274 67.888  67.077  1.00 109.43 ? 746 THR A C   1 
ATOM   4523 O O   . THR A 1 765 ? -13.389 69.121  67.149  1.00 108.56 ? 746 THR A O   1 
ATOM   4524 C CB  . THR A 1 765 ? -12.846 67.322  64.682  1.00 102.65 ? 746 THR A CB  1 
ATOM   4525 O OG1 . THR A 1 765 ? -12.411 68.691  64.645  1.00 106.13 ? 746 THR A OG1 1 
ATOM   4526 C CG2 . THR A 1 765 ? -13.549 66.984  63.396  1.00 111.08 ? 746 THR A CG2 1 
ATOM   4527 N N   . VAL A 1 766 ? -12.741 67.136  68.041  1.00 105.53 ? 747 VAL A N   1 
ATOM   4528 C CA  . VAL A 1 766 ? -12.058 67.675  69.212  1.00 96.08  ? 747 VAL A CA  1 
ATOM   4529 C C   . VAL A 1 766 ? -10.759 66.901  69.347  1.00 90.81  ? 747 VAL A C   1 
ATOM   4530 O O   . VAL A 1 766 ? -10.766 65.667  69.259  1.00 91.81  ? 747 VAL A O   1 
ATOM   4531 C CB  . VAL A 1 766 ? -12.883 67.493  70.497  1.00 95.93  ? 747 VAL A CB  1 
ATOM   4532 C CG1 . VAL A 1 766 ? -12.173 68.137  71.642  1.00 93.02  ? 747 VAL A CG1 1 
ATOM   4533 C CG2 . VAL A 1 766 ? -14.313 67.968  70.326  1.00 102.28 ? 747 VAL A CG2 1 
ATOM   4534 N N   . VAL A 1 767 ? -9.648  67.593  69.569  1.00 87.48  ? 748 VAL A N   1 
ATOM   4535 C CA  . VAL A 1 767 ? -8.391  66.882  69.769  1.00 89.94  ? 748 VAL A CA  1 
ATOM   4536 C C   . VAL A 1 767 ? -7.692  67.444  71.001  1.00 90.06  ? 748 VAL A C   1 
ATOM   4537 O O   . VAL A 1 767 ? -7.322  68.627  71.026  1.00 89.38  ? 748 VAL A O   1 
ATOM   4538 C CB  . VAL A 1 767 ? -7.472  66.935  68.536  1.00 89.51  ? 748 VAL A CB  1 
ATOM   4539 C CG1 . VAL A 1 767 ? -7.253  68.329  68.100  1.00 96.28  ? 748 VAL A CG1 1 
ATOM   4540 C CG2 . VAL A 1 767 ? -6.136  66.313  68.869  1.00 90.70  ? 748 VAL A CG2 1 
ATOM   4541 N N   . SER A 1 768 ? -7.505  66.591  72.013  1.00 82.38  ? 749 SER A N   1 
ATOM   4542 C CA  . SER A 1 768 ? -6.856  66.997  73.249  1.00 76.38  ? 749 SER A CA  1 
ATOM   4543 C C   . SER A 1 768 ? -5.377  67.295  73.016  1.00 77.70  ? 749 SER A C   1 
ATOM   4544 O O   . SER A 1 768 ? -4.739  66.764  72.101  1.00 82.02  ? 749 SER A O   1 
ATOM   4545 C CB  . SER A 1 768 ? -6.985  65.911  74.308  1.00 74.99  ? 749 SER A CB  1 
ATOM   4546 O OG  . SER A 1 768 ? -5.955  64.943  74.170  1.00 71.44  ? 749 SER A OG  1 
ATOM   4547 N N   . ARG A 1 769 ? -4.835  68.170  73.857  1.00 73.77  ? 750 ARG A N   1 
ATOM   4548 C CA  . ARG A 1 769 ? -3.406  68.500  73.838  1.00 80.75  ? 750 ARG A CA  1 
ATOM   4549 C C   . ARG A 1 769 ? -3.048  68.768  75.310  1.00 84.68  ? 750 ARG A C   1 
ATOM   4550 O O   . ARG A 1 769 ? -2.929  69.917  75.779  1.00 80.74  ? 750 ARG A O   1 
ATOM   4551 C CB  . ARG A 1 769 ? -3.063  69.682  72.927  1.00 81.28  ? 750 ARG A CB  1 
ATOM   4552 C CG  . ARG A 1 769 ? -3.288  69.462  71.429  1.00 86.28  ? 750 ARG A CG  1 
ATOM   4553 C CD  . ARG A 1 769 ? -3.183  70.762  70.600  1.00 88.59  ? 750 ARG A CD  1 
ATOM   4554 N NE  . ARG A 1 769 ? -1.814  71.303  70.500  1.00 100.65 ? 750 ARG A NE  1 
ATOM   4555 C CZ  . ARG A 1 769 ? -1.360  72.406  71.129  1.00 104.89 ? 750 ARG A CZ  1 
ATOM   4556 N NH1 . ARG A 1 769 ? -2.156  73.124  71.933  1.00 98.65  ? 750 ARG A NH1 1 
ATOM   4557 N NH2 . ARG A 1 769 ? -0.094  72.807  70.960  1.00 94.08  ? 750 ARG A NH2 1 
ATOM   4558 N N   . TRP A 1 770 ? -2.882  67.663  76.050  1.00 81.08  ? 751 TRP A N   1 
ATOM   4559 C CA  . TRP A 1 770 ? -2.745  67.733  77.496  1.00 72.14  ? 751 TRP A CA  1 
ATOM   4560 C C   . TRP A 1 770 ? -1.390  68.280  77.907  1.00 73.83  ? 751 TRP A C   1 
ATOM   4561 O O   . TRP A 1 770 ? -1.297  69.016  78.893  1.00 75.09  ? 751 TRP A O   1 
ATOM   4562 C CB  . TRP A 1 770 ? -2.973  66.360  78.107  1.00 65.91  ? 751 TRP A CB  1 
ATOM   4563 C CG  . TRP A 1 770 ? -4.406  66.007  78.245  1.00 68.97  ? 751 TRP A CG  1 
ATOM   4564 C CD1 . TRP A 1 770 ? -5.085  65.054  77.549  1.00 75.86  ? 751 TRP A CD1 1 
ATOM   4565 C CD2 . TRP A 1 770 ? -5.344  66.579  79.148  1.00 70.08  ? 751 TRP A CD2 1 
ATOM   4566 N NE1 . TRP A 1 770 ? -6.394  64.997  77.959  1.00 71.04  ? 751 TRP A NE1 1 
ATOM   4567 C CE2 . TRP A 1 770 ? -6.580  65.931  78.937  1.00 69.65  ? 751 TRP A CE2 1 
ATOM   4568 C CE3 . TRP A 1 770 ? -5.265  67.581  80.110  1.00 70.97  ? 751 TRP A CE3 1 
ATOM   4569 C CZ2 . TRP A 1 770 ? -7.721  66.258  79.645  1.00 71.40  ? 751 TRP A CZ2 1 
ATOM   4570 C CZ3 . TRP A 1 770 ? -6.393  67.894  80.818  1.00 73.22  ? 751 TRP A CZ3 1 
ATOM   4571 C CH2 . TRP A 1 770 ? -7.612  67.232  80.586  1.00 72.85  ? 751 TRP A CH2 1 
ATOM   4572 N N   . ARG A 1 771 ? -0.345  67.992  77.161  1.00 70.39  ? 752 ARG A N   1 
ATOM   4573 C CA  . ARG A 1 771 ? 0.959   68.508  77.618  1.00 68.15  ? 752 ARG A CA  1 
ATOM   4574 C C   . ARG A 1 771 ? 0.960   70.013  77.440  1.00 70.72  ? 752 ARG A C   1 
ATOM   4575 O O   . ARG A 1 771 ? 1.648   70.696  78.148  1.00 65.87  ? 752 ARG A O   1 
ATOM   4576 C CB  . ARG A 1 771 ? 2.074   67.897  76.786  1.00 65.45  ? 752 ARG A CB  1 
ATOM   4577 C CG  . ARG A 1 771 ? 3.425   67.908  77.476  1.00 60.80  ? 752 ARG A CG  1 
ATOM   4578 C CD  . ARG A 1 771 ? 3.412   67.028  78.692  1.00 61.65  ? 752 ARG A CD  1 
ATOM   4579 N NE  . ARG A 1 771 ? 4.532   66.132  78.648  1.00 68.47  ? 752 ARG A NE  1 
ATOM   4580 C CZ  . ARG A 1 771 ? 4.644   65.061  79.387  1.00 75.45  ? 752 ARG A CZ  1 
ATOM   4581 N NH1 . ARG A 1 771 ? 3.707   64.739  80.248  1.00 73.51  ? 752 ARG A NH1 1 
ATOM   4582 N NH2 . ARG A 1 771 ? 5.694   64.291  79.265  1.00 80.66  ? 752 ARG A NH2 1 
ATOM   4583 N N   . ALA A 1 772 ? 0.277   70.473  76.419  1.00 78.20  ? 753 ALA A N   1 
ATOM   4584 C CA  . ALA A 1 772 ? 0.184   71.912  76.130  1.00 79.82  ? 753 ALA A CA  1 
ATOM   4585 C C   . ALA A 1 772 ? -0.628  72.624  77.198  1.00 73.66  ? 753 ALA A C   1 
ATOM   4586 O O   . ALA A 1 772 ? -0.320  73.753  77.500  1.00 74.10  ? 753 ALA A O   1 
ATOM   4587 C CB  . ALA A 1 772 ? -0.445  72.092  74.791  1.00 86.10  ? 753 ALA A CB  1 
ATOM   4588 N N   . ASP A 1 773 ? -1.667  71.975  77.698  1.00 73.73  ? 754 ASP A N   1 
ATOM   4589 C CA  . ASP A 1 773 ? -2.547  72.626  78.689  1.00 70.37  ? 754 ASP A CA  1 
ATOM   4590 C C   . ASP A 1 773 ? -1.711  73.069  79.871  1.00 72.24  ? 754 ASP A C   1 
ATOM   4591 O O   . ASP A 1 773 ? -1.067  72.247  80.448  1.00 76.87  ? 754 ASP A O   1 
ATOM   4592 C CB  . ASP A 1 773 ? -3.554  71.626  79.225  1.00 71.63  ? 754 ASP A CB  1 
ATOM   4593 C CG  . ASP A 1 773 ? -4.596  72.299  80.068  1.00 73.17  ? 754 ASP A CG  1 
ATOM   4594 O OD1 . ASP A 1 773 ? -4.584  73.500  80.093  1.00 75.42  ? 754 ASP A OD1 1 
ATOM   4595 O OD2 . ASP A 1 773 ? -5.394  71.612  80.677  1.00 70.94  ? 754 ASP A OD2 1 
ATOM   4596 N N   . PRO A 1 774 ? -1.792  74.323  80.318  1.00 73.02  ? 755 PRO A N   1 
ATOM   4597 C CA  . PRO A 1 774 ? -0.966  74.783  81.404  1.00 75.33  ? 755 PRO A CA  1 
ATOM   4598 C C   . PRO A 1 774 ? -1.544  74.482  82.783  1.00 73.57  ? 755 PRO A C   1 
ATOM   4599 O O   . PRO A 1 774 ? -0.911  74.764  83.728  1.00 70.67  ? 755 PRO A O   1 
ATOM   4600 C CB  . PRO A 1 774 ? -0.995  76.274  81.136  1.00 71.64  ? 755 PRO A CB  1 
ATOM   4601 C CG  . PRO A 1 774 ? -2.383  76.501  80.689  1.00 69.43  ? 755 PRO A CG  1 
ATOM   4602 C CD  . PRO A 1 774 ? -2.648  75.339  79.774  1.00 68.53  ? 755 PRO A CD  1 
ATOM   4603 N N   . TRP A 1 775 ? -2.758  73.970  82.836  1.00 67.39  ? 756 TRP A N   1 
ATOM   4604 C CA  . TRP A 1 775 ? -3.371  73.600  84.127  1.00 67.53  ? 756 TRP A CA  1 
ATOM   4605 C C   . TRP A 1 775 ? -3.152  72.117  84.391  1.00 73.72  ? 756 TRP A C   1 
ATOM   4606 O O   . TRP A 1 775 ? -3.744  71.592  85.295  1.00 69.30  ? 756 TRP A O   1 
ATOM   4607 C CB  . TRP A 1 775 ? -4.849  73.939  84.110  1.00 67.54  ? 756 TRP A CB  1 
ATOM   4608 C CG  . TRP A 1 775 ? -5.105  75.349  83.707  1.00 76.20  ? 756 TRP A CG  1 
ATOM   4609 C CD1 . TRP A 1 775 ? -6.044  75.792  82.840  1.00 77.49  ? 756 TRP A CD1 1 
ATOM   4610 C CD2 . TRP A 1 775 ? -4.412  76.508  84.165  1.00 76.56  ? 756 TRP A CD2 1 
ATOM   4611 N NE1 . TRP A 1 775 ? -5.977  77.146  82.724  1.00 75.02  ? 756 TRP A NE1 1 
ATOM   4612 C CE2 . TRP A 1 775 ? -4.985  77.608  83.525  1.00 70.95  ? 756 TRP A CE2 1 
ATOM   4613 C CE3 . TRP A 1 775 ? -3.369  76.723  85.051  1.00 75.29  ? 756 TRP A CE3 1 
ATOM   4614 C CZ2 . TRP A 1 775 ? -4.554  78.902  83.742  1.00 69.66  ? 756 TRP A CZ2 1 
ATOM   4615 C CZ3 . TRP A 1 775 ? -2.939  78.002  85.267  1.00 76.23  ? 756 TRP A CZ3 1 
ATOM   4616 C CH2 . TRP A 1 775 ? -3.521  79.074  84.618  1.00 71.90  ? 756 TRP A CH2 1 
ATOM   4617 N N   . ALA A 1 776 ? -2.452  71.447  83.501  1.00 72.89  ? 757 ALA A N   1 
ATOM   4618 C CA  . ALA A 1 776 ? -2.134  70.030  83.685  1.00 61.62  ? 757 ALA A CA  1 
ATOM   4619 C C   . ALA A 1 776 ? -0.677  69.830  83.337  1.00 64.68  ? 757 ALA A C   1 
ATOM   4620 O O   . ALA A 1 776 ? 0.001   69.169  84.061  1.00 66.28  ? 757 ALA A O   1 
ATOM   4621 C CB  . ALA A 1 776 ? -2.983  69.219  82.776  1.00 63.54  ? 757 ALA A CB  1 
ATOM   4622 N N   . ARG A 1 777 ? -0.292  70.276  82.154  1.00 65.36  ? 758 ARG A N   1 
ATOM   4623 C CA  . ARG A 1 777 ? 1.073   70.131  81.601  1.00 65.49  ? 758 ARG A CA  1 
ATOM   4624 C C   . ARG A 1 777 ? 1.454   68.660  81.534  1.00 65.75  ? 758 ARG A C   1 
ATOM   4625 O O   . ARG A 1 777 ? 2.606   68.366  81.716  1.00 62.39  ? 758 ARG A O   1 
ATOM   4626 C CB  . ARG A 1 777 ? 2.087   70.940  82.397  1.00 68.61  ? 758 ARG A CB  1 
ATOM   4627 C CG  . ARG A 1 777 ? 1.929   72.437  82.236  1.00 70.28  ? 758 ARG A CG  1 
ATOM   4628 C CD  . ARG A 1 777 ? 3.244   73.057  81.853  1.00 79.47  ? 758 ARG A CD  1 
ATOM   4629 N NE  . ARG A 1 777 ? 3.016   73.926  80.723  1.00 89.29  ? 758 ARG A NE  1 
ATOM   4630 C CZ  . ARG A 1 777 ? 2.491   75.125  80.820  1.00 93.09  ? 758 ARG A CZ  1 
ATOM   4631 N NH1 . ARG A 1 777 ? 2.168   75.608  82.001  1.00 94.72  ? 758 ARG A NH1 1 
ATOM   4632 N NH2 . ARG A 1 777 ? 2.309   75.852  79.742  1.00 88.61  ? 758 ARG A NH2 1 
ATOM   4633 N N   . GLY A 1 778 ? 0.509   67.809  81.161  1.00 62.09  ? 759 GLY A N   1 
ATOM   4634 C CA  . GLY A 1 778 ? 0.692   66.357  81.110  1.00 63.67  ? 759 GLY A CA  1 
ATOM   4635 C C   . GLY A 1 778 ? -0.619  65.649  81.325  1.00 61.87  ? 759 GLY A C   1 
ATOM   4636 O O   . GLY A 1 778 ? -1.614  66.287  81.440  1.00 65.23  ? 759 GLY A O   1 
ATOM   4637 N N   . SER A 1 779 ? -0.589  64.336  81.362  1.00 60.08  ? 760 SER A N   1 
ATOM   4638 C CA  . SER A 1 779 ? -1.784  63.522  81.552  1.00 66.88  ? 760 SER A CA  1 
ATOM   4639 C C   . SER A 1 779 ? -1.786  62.848  82.949  1.00 69.50  ? 760 SER A C   1 
ATOM   4640 O O   . SER A 1 779 ? -2.638  63.159  83.760  1.00 71.40  ? 760 SER A O   1 
ATOM   4641 C CB  . SER A 1 779 ? -1.905  62.457  80.471  1.00 65.42  ? 760 SER A CB  1 
ATOM   4642 O OG  . SER A 1 779 ? -0.744  61.642  80.460  1.00 68.10  ? 760 SER A OG  1 
ATOM   4643 N N   . TYR A 1 780 ? -0.880  61.928  83.206  1.00 62.08  ? 761 TYR A N   1 
ATOM   4644 C CA  . TYR A 1 780 ? -0.778  61.432  84.560  1.00 61.95  ? 761 TYR A CA  1 
ATOM   4645 C C   . TYR A 1 780 ? 0.637   60.955  84.827  1.00 65.36  ? 761 TYR A C   1 
ATOM   4646 O O   . TYR A 1 780 ? 1.503   60.971  83.957  1.00 67.80  ? 761 TYR A O   1 
ATOM   4647 C CB  . TYR A 1 780 ? -1.796  60.341  84.826  1.00 68.94  ? 761 TYR A CB  1 
ATOM   4648 C CG  . TYR A 1 780 ? -2.022  59.393  83.698  1.00 75.70  ? 761 TYR A CG  1 
ATOM   4649 C CD1 . TYR A 1 780 ? -1.183  58.304  83.525  1.00 73.50  ? 761 TYR A CD1 1 
ATOM   4650 C CD2 . TYR A 1 780 ? -3.096  59.560  82.813  1.00 78.79  ? 761 TYR A CD2 1 
ATOM   4651 C CE1 . TYR A 1 780 ? -1.382  57.416  82.506  1.00 75.50  ? 761 TYR A CE1 1 
ATOM   4652 C CE2 . TYR A 1 780 ? -3.309  58.659  81.782  1.00 77.29  ? 761 TYR A CE2 1 
ATOM   4653 C CZ  . TYR A 1 780 ? -2.437  57.593  81.643  1.00 77.80  ? 761 TYR A CZ  1 
ATOM   4654 O OH  . TYR A 1 780 ? -2.595  56.675  80.654  1.00 82.95  ? 761 TYR A OH  1 
ATOM   4655 N N   . SER A 1 781 ? 0.872   60.564  86.060  1.00 66.63  ? 762 SER A N   1 
ATOM   4656 C CA  . SER A 1 781 ? 2.204   60.225  86.502  1.00 65.35  ? 762 SER A CA  1 
ATOM   4657 C C   . SER A 1 781 ? 2.556   58.798  86.096  1.00 62.18  ? 762 SER A C   1 
ATOM   4658 O O   . SER A 1 781 ? 1.705   58.006  85.705  1.00 67.88  ? 762 SER A O   1 
ATOM   4659 C CB  . SER A 1 781 ? 2.287   60.395  88.011  1.00 69.30  ? 762 SER A CB  1 
ATOM   4660 O OG  . SER A 1 781 ? 1.377   59.498  88.643  1.00 70.84  ? 762 SER A OG  1 
ATOM   4661 N N   . TYR A 1 782 ? 3.836   58.476  86.190  1.00 59.57  ? 763 TYR A N   1 
ATOM   4662 C CA  . TYR A 1 782 ? 4.342   57.163  85.833  1.00 60.48  ? 763 TYR A CA  1 
ATOM   4663 C C   . TYR A 1 782 ? 5.632   56.990  86.597  1.00 65.28  ? 763 TYR A C   1 
ATOM   4664 O O   . TYR A 1 782 ? 6.308   57.973  86.902  1.00 69.81  ? 763 TYR A O   1 
ATOM   4665 C CB  . TYR A 1 782 ? 4.598   56.989  84.328  1.00 57.05  ? 763 TYR A CB  1 
ATOM   4666 C CG  . TYR A 1 782 ? 5.740   57.805  83.739  1.00 60.03  ? 763 TYR A CG  1 
ATOM   4667 C CD1 . TYR A 1 782 ? 7.080   57.438  83.917  1.00 63.16  ? 763 TYR A CD1 1 
ATOM   4668 C CD2 . TYR A 1 782 ? 5.477   58.929  82.965  1.00 61.14  ? 763 TYR A CD2 1 
ATOM   4669 C CE1 . TYR A 1 782 ? 8.128   58.194  83.349  1.00 61.72  ? 763 TYR A CE1 1 
ATOM   4670 C CE2 . TYR A 1 782 ? 6.504   59.685  82.410  1.00 64.65  ? 763 TYR A CE2 1 
ATOM   4671 C CZ  . TYR A 1 782 ? 7.830   59.317  82.594  1.00 65.41  ? 763 TYR A CZ  1 
ATOM   4672 O OH  . TYR A 1 782 ? 8.835   60.105  82.033  1.00 65.24  ? 763 TYR A OH  1 
ATOM   4673 N N   . VAL A 1 783 ? 5.980   55.751  86.924  1.00 68.33  ? 764 VAL A N   1 
ATOM   4674 C CA  . VAL A 1 783 ? 7.174   55.592  87.740  1.00 65.76  ? 764 VAL A CA  1 
ATOM   4675 C C   . VAL A 1 783 ? 8.354   55.694  86.782  1.00 68.03  ? 764 VAL A C   1 
ATOM   4676 O O   . VAL A 1 783 ? 8.631   54.768  86.019  1.00 70.72  ? 764 VAL A O   1 
ATOM   4677 C CB  . VAL A 1 783 ? 7.178   54.281  88.512  1.00 64.67  ? 764 VAL A CB  1 
ATOM   4678 C CG1 . VAL A 1 783 ? 8.397   54.242  89.427  1.00 62.58  ? 764 VAL A CG1 1 
ATOM   4679 C CG2 . VAL A 1 783 ? 5.867   54.115  89.231  1.00 68.55  ? 764 VAL A CG2 1 
ATOM   4680 N N   . ALA A 1 784 ? 9.022   56.840  86.784  1.00 65.83  ? 765 ALA A N   1 
ATOM   4681 C CA  . ALA A 1 784 ? 10.131  57.033  85.873  1.00 64.89  ? 765 ALA A CA  1 
ATOM   4682 C C   . ALA A 1 784 ? 11.297  56.157  86.283  1.00 64.64  ? 765 ALA A C   1 
ATOM   4683 O O   . ALA A 1 784 ? 11.412  55.725  87.431  1.00 64.36  ? 765 ALA A O   1 
ATOM   4684 C CB  . ALA A 1 784 ? 10.565  58.492  85.843  1.00 66.53  ? 765 ALA A CB  1 
ATOM   4685 N N   . ALA A 1 785 ? 12.155  55.873  85.319  1.00 66.23  ? 766 ALA A N   1 
ATOM   4686 C CA  . ALA A 1 785 ? 13.392  55.203  85.664  1.00 71.56  ? 766 ALA A CA  1 
ATOM   4687 C C   . ALA A 1 785 ? 14.172  56.097  86.609  1.00 74.69  ? 766 ALA A C   1 
ATOM   4688 O O   . ALA A 1 785 ? 14.233  57.319  86.427  1.00 74.97  ? 766 ALA A O   1 
ATOM   4689 C CB  . ALA A 1 785 ? 14.207  54.873  84.418  1.00 72.99  ? 766 ALA A CB  1 
ATOM   4690 N N   . GLY A 1 786 ? 14.735  55.485  87.648  1.00 72.96  ? 767 GLY A N   1 
ATOM   4691 C CA  . GLY A 1 786 ? 15.337  56.229  88.723  1.00 66.91  ? 767 GLY A CA  1 
ATOM   4692 C C   . GLY A 1 786 ? 14.360  56.678  89.779  1.00 69.54  ? 767 GLY A C   1 
ATOM   4693 O O   . GLY A 1 786 ? 14.787  57.129  90.852  1.00 74.61  ? 767 GLY A O   1 
ATOM   4694 N N   . SER A 1 787 ? 13.066  56.582  89.524  1.00 65.90  ? 768 SER A N   1 
ATOM   4695 C CA  . SER A 1 787 ? 12.083  56.863  90.549  1.00 65.59  ? 768 SER A CA  1 
ATOM   4696 C C   . SER A 1 787 ? 11.663  55.537  91.171  1.00 62.18  ? 768 SER A C   1 
ATOM   4697 O O   . SER A 1 787 ? 12.166  54.471  90.816  1.00 70.55  ? 768 SER A O   1 
ATOM   4698 C CB  . SER A 1 787 ? 10.900  57.636  89.951  1.00 70.02  ? 768 SER A CB  1 
ATOM   4699 O OG  . SER A 1 787 ? 10.080  58.255  90.936  1.00 64.32  ? 768 SER A OG  1 
ATOM   4700 N N   . SER A 1 788 ? 10.765  55.655  92.115  1.00 63.91  ? 769 SER A N   1 
ATOM   4701 C CA  . SER A 1 788 ? 10.274  54.473  92.831  1.00 68.18  ? 769 SER A CA  1 
ATOM   4702 C C   . SER A 1 788 ? 8.900   54.783  93.393  1.00 66.64  ? 769 SER A C   1 
ATOM   4703 O O   . SER A 1 788 ? 8.369   55.827  93.143  1.00 67.45  ? 769 SER A O   1 
ATOM   4704 C CB  . SER A 1 788 ? 11.260  54.106  93.882  1.00 66.80  ? 769 SER A CB  1 
ATOM   4705 O OG  . SER A 1 788 ? 10.710  54.135  95.172  1.00 63.66  ? 769 SER A OG  1 
ATOM   4706 N N   . GLY A 1 789 ? 8.359   53.885  94.183  1.00 73.60  ? 770 GLY A N   1 
ATOM   4707 C CA  . GLY A 1 789 ? 7.054   54.172  94.783  1.00 71.11  ? 770 GLY A CA  1 
ATOM   4708 C C   . GLY A 1 789 ? 7.212   55.072  95.983  1.00 72.40  ? 770 GLY A C   1 
ATOM   4709 O O   . GLY A 1 789 ? 6.271   55.705  96.335  1.00 70.70  ? 770 GLY A O   1 
ATOM   4710 N N   . ASN A 1 790 ? 8.409   55.172  96.545  1.00 71.68  ? 771 ASN A N   1 
ATOM   4711 C CA  . ASN A 1 790 ? 8.678   56.039  97.709  1.00 70.81  ? 771 ASN A CA  1 
ATOM   4712 C C   . ASN A 1 790 ? 8.537   57.495  97.309  1.00 65.56  ? 771 ASN A C   1 
ATOM   4713 O O   . ASN A 1 790 ? 8.157   58.260  98.138  1.00 70.87  ? 771 ASN A O   1 
ATOM   4714 C CB  . ASN A 1 790 ? 10.073  55.809  98.254  1.00 75.64  ? 771 ASN A CB  1 
ATOM   4715 C CG  . ASN A 1 790 ? 10.082  54.780  99.352  1.00 91.20  ? 771 ASN A CG  1 
ATOM   4716 O OD1 . ASN A 1 790 ? 9.534   55.014  100.416 1.00 95.46  ? 771 ASN A OD1 1 
ATOM   4717 N ND2 . ASN A 1 790 ? 10.698  53.645  99.107  1.00 93.36  ? 771 ASN A ND2 1 
ATOM   4718 N N   . ASP A 1 791 ? 8.806   57.853  96.063  1.00 67.15  ? 772 ASP A N   1 
ATOM   4719 C CA  . ASP A 1 791 ? 8.642   59.248  95.612  1.00 60.22  ? 772 ASP A CA  1 
ATOM   4720 C C   . ASP A 1 791 ? 7.196   59.670  95.792  1.00 65.30  ? 772 ASP A C   1 
ATOM   4721 O O   . ASP A 1 791 ? 6.978   60.759  96.216  1.00 68.38  ? 772 ASP A O   1 
ATOM   4722 C CB  . ASP A 1 791 ? 9.155   59.421  94.201  1.00 58.74  ? 772 ASP A CB  1 
ATOM   4723 C CG  . ASP A 1 791 ? 10.647  59.526  94.181  1.00 63.93  ? 772 ASP A CG  1 
ATOM   4724 O OD1 . ASP A 1 791 ? 11.226  59.534  95.232  1.00 62.41  ? 772 ASP A OD1 1 
ATOM   4725 O OD2 . ASP A 1 791 ? 11.190  59.587  93.115  1.00 64.35  ? 772 ASP A OD2 1 
ATOM   4726 N N   . TYR A 1 792 ? 6.232   58.813  95.509  1.00 66.71  ? 773 TYR A N   1 
ATOM   4727 C CA  . TYR A 1 792 ? 4.832   59.185  95.785  1.00 67.50  ? 773 TYR A CA  1 
ATOM   4728 C C   . TYR A 1 792 ? 4.682   59.472  97.273  1.00 68.02  ? 773 TYR A C   1 
ATOM   4729 O O   . TYR A 1 792 ? 4.036   60.415  97.609  1.00 73.09  ? 773 TYR A O   1 
ATOM   4730 C CB  . TYR A 1 792 ? 3.916   58.059  95.344  1.00 64.73  ? 773 TYR A CB  1 
ATOM   4731 C CG  . TYR A 1 792 ? 3.869   57.868  93.859  1.00 63.98  ? 773 TYR A CG  1 
ATOM   4732 C CD1 . TYR A 1 792 ? 3.054   58.631  93.068  1.00 69.40  ? 773 TYR A CD1 1 
ATOM   4733 C CD2 . TYR A 1 792 ? 4.644   56.922  93.249  1.00 68.53  ? 773 TYR A CD2 1 
ATOM   4734 C CE1 . TYR A 1 792 ? 3.007   58.451  91.704  1.00 73.62  ? 773 TYR A CE1 1 
ATOM   4735 C CE2 . TYR A 1 792 ? 4.614   56.725  91.888  1.00 72.37  ? 773 TYR A CE2 1 
ATOM   4736 C CZ  . TYR A 1 792 ? 3.791   57.496  91.111  1.00 75.35  ? 773 TYR A CZ  1 
ATOM   4737 O OH  . TYR A 1 792 ? 3.750   57.312  89.774  1.00 75.44  ? 773 TYR A OH  1 
ATOM   4738 N N   . ASP A 1 793 ? 5.249   58.643  98.134  1.00 64.72  ? 774 ASP A N   1 
ATOM   4739 C CA  . ASP A 1 793 ? 5.192   58.883  99.587  1.00 59.77  ? 774 ASP A CA  1 
ATOM   4740 C C   . ASP A 1 793 ? 5.760   60.264  99.858  1.00 63.36  ? 774 ASP A C   1 
ATOM   4741 O O   . ASP A 1 793 ? 5.087   60.989  100.527 1.00 69.46  ? 774 ASP A O   1 
ATOM   4742 C CB  . ASP A 1 793 ? 5.856   57.740  100.326 1.00 66.52  ? 774 ASP A CB  1 
ATOM   4743 C CG  . ASP A 1 793 ? 4.930   56.560  100.416 1.00 72.87  ? 774 ASP A CG  1 
ATOM   4744 O OD1 . ASP A 1 793 ? 3.754   56.746  100.153 1.00 75.63  ? 774 ASP A OD1 1 
ATOM   4745 O OD2 . ASP A 1 793 ? 5.395   55.491  100.752 1.00 73.38  ? 774 ASP A OD2 1 
ATOM   4746 N N   . LEU A 1 794 ? 6.992   60.537  99.447  1.00 62.71  ? 775 LEU A N   1 
ATOM   4747 C CA  . LEU A 1 794 ? 7.529   61.893  99.484  1.00 61.57  ? 775 LEU A CA  1 
ATOM   4748 C C   . LEU A 1 794 ? 6.484   62.926  99.063  1.00 63.19  ? 775 LEU A C   1 
ATOM   4749 O O   . LEU A 1 794 ? 6.133   63.783  99.870  1.00 70.85  ? 775 LEU A O   1 
ATOM   4750 C CB  . LEU A 1 794 ? 8.761   62.009  98.602  1.00 60.49  ? 775 LEU A CB  1 
ATOM   4751 C CG  . LEU A 1 794 ? 9.920   61.300  99.278  1.00 56.24  ? 775 LEU A CG  1 
ATOM   4752 C CD1 . LEU A 1 794 ? 11.195  61.560  98.539  1.00 62.03  ? 775 LEU A CD1 1 
ATOM   4753 C CD2 . LEU A 1 794 ? 10.002  61.816  100.678 1.00 57.02  ? 775 LEU A CD2 1 
ATOM   4754 N N   . MET A 1 795 ? 5.925   62.850  97.841  1.00 56.35  ? 776 MET A N   1 
ATOM   4755 C CA  . MET A 1 795 ? 4.922   63.849  97.480  1.00 62.58  ? 776 MET A CA  1 
ATOM   4756 C C   . MET A 1 795 ? 3.849   64.084  98.517  1.00 66.77  ? 776 MET A C   1 
ATOM   4757 O O   . MET A 1 795 ? 3.343   65.205  98.634  1.00 71.82  ? 776 MET A O   1 
ATOM   4758 C CB  . MET A 1 795 ? 4.131   63.544  96.230  1.00 72.35  ? 776 MET A CB  1 
ATOM   4759 C CG  . MET A 1 795 ? 4.881   63.598  94.976  1.00 73.54  ? 776 MET A CG  1 
ATOM   4760 S SD  . MET A 1 795 ? 5.837   65.102  94.782  1.00 76.36  ? 776 MET A SD  1 
ATOM   4761 C CE  . MET A 1 795 ? 4.543   66.347  94.786  1.00 74.96  ? 776 MET A CE  1 
ATOM   4762 N N   . ALA A 1 796 ? 3.444   63.060  99.246  1.00 64.48  ? 777 ALA A N   1 
ATOM   4763 C CA  . ALA A 1 796 ? 2.318   63.312  100.124 1.00 66.18  ? 777 ALA A CA  1 
ATOM   4764 C C   . ALA A 1 796 ? 2.718   63.812  101.520 1.00 68.23  ? 777 ALA A C   1 
ATOM   4765 O O   . ALA A 1 796 ? 1.829   64.265  102.257 1.00 72.58  ? 777 ALA A O   1 
ATOM   4766 C CB  . ALA A 1 796 ? 1.430   62.062  100.175 1.00 63.87  ? 777 ALA A CB  1 
ATOM   4767 N N   . GLN A 1 797 ? 3.990   63.730  101.888 1.00 61.32  ? 778 GLN A N   1 
ATOM   4768 C CA  . GLN A 1 797 ? 4.333   64.230  103.234 1.00 69.99  ? 778 GLN A CA  1 
ATOM   4769 C C   . GLN A 1 797 ? 4.104   65.724  103.194 1.00 64.00  ? 778 GLN A C   1 
ATOM   4770 O O   . GLN A 1 797 ? 4.568   66.329  102.288 1.00 63.81  ? 778 GLN A O   1 
ATOM   4771 C CB  . GLN A 1 797 ? 5.763   63.896  103.630 1.00 70.39  ? 778 GLN A CB  1 
ATOM   4772 C CG  . GLN A 1 797 ? 5.936   62.538  104.300 1.00 88.20  ? 778 GLN A CG  1 
ATOM   4773 C CD  . GLN A 1 797 ? 4.742   61.966  105.029 1.00 98.07  ? 778 GLN A CD  1 
ATOM   4774 O OE1 . GLN A 1 797 ? 4.036   61.088  104.541 1.00 90.02  ? 778 GLN A OE1 1 
ATOM   4775 N NE2 . GLN A 1 797 ? 4.544   62.423  106.250 1.00 92.58  ? 778 GLN A NE2 1 
ATOM   4776 N N   . PRO A 1 798 ? 3.433   66.335  104.176 1.00 62.69  ? 779 PRO A N   1 
ATOM   4777 C CA  . PRO A 1 798 ? 3.131   67.734  104.138 1.00 65.59  ? 779 PRO A CA  1 
ATOM   4778 C C   . PRO A 1 798 ? 4.307   68.580  104.596 1.00 62.12  ? 779 PRO A C   1 
ATOM   4779 O O   . PRO A 1 798 ? 5.215   68.055  105.088 1.00 68.77  ? 779 PRO A O   1 
ATOM   4780 C CB  . PRO A 1 798 ? 2.013   67.825  105.152 1.00 63.03  ? 779 PRO A CB  1 
ATOM   4781 C CG  . PRO A 1 798 ? 2.443   66.872  106.171 1.00 61.98  ? 779 PRO A CG  1 
ATOM   4782 C CD  . PRO A 1 798 ? 2.940   65.709  105.366 1.00 65.59  ? 779 PRO A CD  1 
ATOM   4783 N N   . ILE A 1 799 ? 4.193   69.887  104.457 1.00 57.16  ? 780 ILE A N   1 
ATOM   4784 C CA  . ILE A 1 799 ? 5.341   70.757  104.798 1.00 64.18  ? 780 ILE A CA  1 
ATOM   4785 C C   . ILE A 1 799 ? 5.076   71.590  106.038 1.00 65.44  ? 780 ILE A C   1 
ATOM   4786 O O   . ILE A 1 799 ? 4.078   72.241  106.108 1.00 61.01  ? 780 ILE A O   1 
ATOM   4787 C CB  . ILE A 1 799 ? 5.638   71.668  103.618 1.00 66.01  ? 780 ILE A CB  1 
ATOM   4788 C CG1 . ILE A 1 799 ? 5.733   70.852  102.342 1.00 67.00  ? 780 ILE A CG1 1 
ATOM   4789 C CG2 . ILE A 1 799 ? 6.913   72.418  103.874 1.00 65.21  ? 780 ILE A CG2 1 
ATOM   4790 C CD1 . ILE A 1 799 ? 7.121   70.728  101.861 1.00 70.64  ? 780 ILE A CD1 1 
ATOM   4791 N N   . THR A 1 800 ? 6.016   71.573  106.962 1.00 69.85  ? 781 THR A N   1 
ATOM   4792 C CA  . THR A 1 800 ? 5.896   72.382  108.181 1.00 70.33  ? 781 THR A CA  1 
ATOM   4793 C C   . THR A 1 800 ? 6.898   73.506  108.037 1.00 69.31  ? 781 THR A C   1 
ATOM   4794 O O   . THR A 1 800 ? 8.060   73.220  107.898 1.00 70.13  ? 781 THR A O   1 
ATOM   4795 C CB  . THR A 1 800 ? 6.244   71.538  109.397 1.00 70.51  ? 781 THR A CB  1 
ATOM   4796 O OG1 . THR A 1 800 ? 5.405   70.399  109.309 1.00 77.07  ? 781 THR A OG1 1 
ATOM   4797 C CG2 . THR A 1 800 ? 5.908   72.224  110.692 1.00 81.57  ? 781 THR A CG2 1 
ATOM   4798 N N   . PRO A 1 801 ? 6.485   74.777  108.101 1.00 71.02  ? 782 PRO A N   1 
ATOM   4799 C CA  . PRO A 1 801 ? 7.393   75.883  107.929 1.00 71.74  ? 782 PRO A CA  1 
ATOM   4800 C C   . PRO A 1 801 ? 8.272   76.146  109.146 1.00 74.61  ? 782 PRO A C   1 
ATOM   4801 O O   . PRO A 1 801 ? 8.054   75.603  110.152 1.00 76.95  ? 782 PRO A O   1 
ATOM   4802 C CB  . PRO A 1 801 ? 6.427   77.050  107.876 1.00 69.06  ? 782 PRO A CB  1 
ATOM   4803 C CG  . PRO A 1 801 ? 5.342   76.610  108.767 1.00 69.62  ? 782 PRO A CG  1 
ATOM   4804 C CD  . PRO A 1 801 ? 5.127   75.192  108.338 1.00 70.81  ? 782 PRO A CD  1 
ATOM   4805 N N   . GLY A 1 802 ? 9.213   77.063  109.021 1.00 74.92  ? 783 GLY A N   1 
ATOM   4806 C CA  . GLY A 1 802 ? 10.099  77.342  110.156 1.00 75.39  ? 783 GLY A CA  1 
ATOM   4807 C C   . GLY A 1 802 ? 9.423   78.219  111.171 1.00 75.15  ? 783 GLY A C   1 
ATOM   4808 O O   . GLY A 1 802 ? 8.461   78.856  110.841 1.00 79.18  ? 783 GLY A O   1 
ATOM   4809 N N   . PRO A 1 803 ? 9.946   78.358  112.389 1.00 77.06  ? 784 PRO A N   1 
ATOM   4810 C CA  . PRO A 1 803 ? 9.300   79.178  113.371 1.00 82.32  ? 784 PRO A CA  1 
ATOM   4811 C C   . PRO A 1 803 ? 9.503   80.634  112.965 1.00 89.28  ? 784 PRO A C   1 
ATOM   4812 O O   . PRO A 1 803 ? 10.529  80.942  112.465 1.00 87.18  ? 784 PRO A O   1 
ATOM   4813 C CB  . PRO A 1 803 ? 10.156  78.899  114.587 1.00 80.44  ? 784 PRO A CB  1 
ATOM   4814 C CG  . PRO A 1 803 ? 11.495  78.695  113.995 1.00 81.40  ? 784 PRO A CG  1 
ATOM   4815 C CD  . PRO A 1 803 ? 11.200  77.802  112.822 1.00 76.71  ? 784 PRO A CD  1 
ATOM   4816 N N   . SER A 1 804 ? 8.507   81.475  113.202 1.00 92.41  ? 785 SER A N   1 
ATOM   4817 C CA  . SER A 1 804 ? 8.615   82.902  112.833 1.00 93.49  ? 785 SER A CA  1 
ATOM   4818 C C   . SER A 1 804 ? 9.672   83.518  113.734 1.00 98.52  ? 785 SER A C   1 
ATOM   4819 O O   . SER A 1 804 ? 10.680  83.997  113.233 1.00 89.18  ? 785 SER A O   1 
ATOM   4820 C CB  . SER A 1 804 ? 7.304   83.575  113.032 1.00 94.91  ? 785 SER A CB  1 
ATOM   4821 O OG  . SER A 1 804 ? 6.523   83.532  111.855 1.00 89.88  ? 785 SER A OG  1 
ATOM   4822 N N   . ILE A 1 805 ? 9.414   83.496  115.033 1.00 99.02  ? 786 ILE A N   1 
ATOM   4823 C CA  . ILE A 1 805 ? 10.387  84.032  116.011 1.00 94.55  ? 786 ILE A CA  1 
ATOM   4824 C C   . ILE A 1 805 ? 11.371  82.914  116.274 1.00 101.10 ? 786 ILE A C   1 
ATOM   4825 O O   . ILE A 1 805 ? 10.937  81.884  116.722 1.00 101.61 ? 786 ILE A O   1 
ATOM   4826 C CB  . ILE A 1 805 ? 9.666   84.371  117.314 1.00 95.43  ? 786 ILE A CB  1 
ATOM   4827 C CG1 . ILE A 1 805 ? 8.292   84.974  117.050 1.00 96.43  ? 786 ILE A CG1 1 
ATOM   4828 C CG2 . ILE A 1 805 ? 10.531  85.278  118.157 1.00 95.72  ? 786 ILE A CG2 1 
ATOM   4829 C CD1 . ILE A 1 805 ? 7.171   84.222  117.708 1.00 92.92  ? 786 ILE A CD1 1 
ATOM   4830 N N   . PRO A 1 806 ? 12.681  83.080  116.053 1.00 105.49 ? 787 PRO A N   1 
ATOM   4831 C CA  . PRO A 1 806 ? 13.619  82.010  116.321 1.00 104.65 ? 787 PRO A CA  1 
ATOM   4832 C C   . PRO A 1 806 ? 13.549  81.628  117.800 1.00 101.59 ? 787 PRO A C   1 
ATOM   4833 O O   . PRO A 1 806 ? 13.492  82.482  118.638 1.00 85.68  ? 787 PRO A O   1 
ATOM   4834 C CB  . PRO A 1 806 ? 14.973  82.620  115.974 1.00 96.51  ? 787 PRO A CB  1 
ATOM   4835 C CG  . PRO A 1 806 ? 14.722  84.090  116.063 1.00 103.55 ? 787 PRO A CG  1 
ATOM   4836 C CD  . PRO A 1 806 ? 13.312  84.275  115.556 1.00 100.05 ? 787 PRO A CD  1 
ATOM   4837 N N   . GLY A 1 807 ? 13.553  80.327  118.055 1.00 103.89 ? 788 GLY A N   1 
ATOM   4838 C CA  . GLY A 1 807 ? 13.469  79.824  119.431 1.00 102.03 ? 788 GLY A CA  1 
ATOM   4839 C C   . GLY A 1 807 ? 12.041  79.523  119.797 1.00 93.73  ? 788 GLY A C   1 
ATOM   4840 O O   . GLY A 1 807 ? 11.793  79.167  120.928 1.00 96.89  ? 788 GLY A O   1 
ATOM   4841 N N   . ALA A 1 808 ? 11.123  79.702  118.868 1.00 87.79  ? 789 ALA A N   1 
ATOM   4842 C CA  . ALA A 1 808 ? 9.735   79.376  119.219 1.00 86.03  ? 789 ALA A CA  1 
ATOM   4843 C C   . ALA A 1 808 ? 9.528   77.887  118.996 1.00 89.77  ? 789 ALA A C   1 
ATOM   4844 O O   . ALA A 1 808 ? 10.298  77.279  118.284 1.00 89.93  ? 789 ALA A O   1 
ATOM   4845 C CB  . ALA A 1 808 ? 8.787   80.188  118.401 1.00 88.47  ? 789 ALA A CB  1 
ATOM   4846 N N   . PRO A 1 809 ? 8.480   77.284  119.559 1.00 89.10  ? 790 PRO A N   1 
ATOM   4847 C CA  . PRO A 1 809 ? 8.279   75.876  119.426 1.00 85.81  ? 790 PRO A CA  1 
ATOM   4848 C C   . PRO A 1 809 ? 7.969   75.476  117.987 1.00 94.80  ? 790 PRO A C   1 
ATOM   4849 O O   . PRO A 1 809 ? 7.362   76.226  117.293 1.00 87.47  ? 790 PRO A O   1 
ATOM   4850 C CB  . PRO A 1 809 ? 7.038   75.650  120.276 1.00 80.85  ? 790 PRO A CB  1 
ATOM   4851 C CG  . PRO A 1 809 ? 6.320   76.938  120.175 1.00 84.32  ? 790 PRO A CG  1 
ATOM   4852 C CD  . PRO A 1 809 ? 7.437   77.939  120.303 1.00 94.19  ? 790 PRO A CD  1 
ATOM   4853 N N   . GLN A 1 810 ? 8.398   74.267  117.633 1.00 97.25  ? 791 GLN A N   1 
ATOM   4854 C CA  . GLN A 1 810 ? 8.192   73.644  116.308 1.00 102.29 ? 791 GLN A CA  1 
ATOM   4855 C C   . GLN A 1 810 ? 6.712   73.750  115.958 1.00 95.27  ? 791 GLN A C   1 
ATOM   4856 O O   . GLN A 1 810 ? 5.894   73.154  116.634 1.00 91.27  ? 791 GLN A O   1 
ATOM   4857 C CB  . GLN A 1 810 ? 8.629   72.187  116.411 1.00 100.91 ? 791 GLN A CB  1 
ATOM   4858 C CG  . GLN A 1 810 ? 9.521   71.721  115.278 1.00 103.29 ? 791 GLN A CG  1 
ATOM   4859 C CD  . GLN A 1 810 ? 8.650   71.581  114.064 1.00 109.71 ? 791 GLN A CD  1 
ATOM   4860 O OE1 . GLN A 1 810 ? 7.708   72.338  113.895 1.00 113.42 ? 791 GLN A OE1 1 
ATOM   4861 N NE2 . GLN A 1 810 ? 8.950   70.610  113.223 1.00 113.40 ? 791 GLN A NE2 1 
ATOM   4862 N N   . PRO A 1 811 ? 6.347   74.424  114.866 1.00 92.93  ? 792 PRO A N   1 
ATOM   4863 C CA  . PRO A 1 811 ? 4.955   74.623  114.553 1.00 97.04  ? 792 PRO A CA  1 
ATOM   4864 C C   . PRO A 1 811 ? 4.194   73.459  113.925 1.00 92.69  ? 792 PRO A C   1 
ATOM   4865 O O   . PRO A 1 811 ? 4.687   72.407  113.802 1.00 85.19  ? 792 PRO A O   1 
ATOM   4866 C CB  . PRO A 1 811 ? 5.016   75.764  113.540 1.00 86.17  ? 792 PRO A CB  1 
ATOM   4867 C CG  . PRO A 1 811 ? 6.325   75.564  112.862 1.00 82.84  ? 792 PRO A CG  1 
ATOM   4868 C CD  . PRO A 1 811 ? 7.252   75.024  113.918 1.00 88.49  ? 792 PRO A CD  1 
ATOM   4869 N N   . ILE A 1 812 ? 2.958   73.748  113.553 1.00 89.54  ? 793 ILE A N   1 
ATOM   4870 C CA  . ILE A 1 812 ? 2.067   72.779  112.880 1.00 79.57  ? 793 ILE A CA  1 
ATOM   4871 C C   . ILE A 1 812 ? 2.463   72.737  111.411 1.00 80.84  ? 793 ILE A C   1 
ATOM   4872 O O   . ILE A 1 812 ? 3.055   73.674  110.931 1.00 80.56  ? 793 ILE A O   1 
ATOM   4873 C CB  . ILE A 1 812 ? 0.626   73.281  113.012 1.00 82.45  ? 793 ILE A CB  1 
ATOM   4874 C CG1 . ILE A 1 812 ? 0.362   73.860  114.395 1.00 91.97  ? 793 ILE A CG1 1 
ATOM   4875 C CG2 . ILE A 1 812 ? -0.352  72.173  112.702 1.00 83.95  ? 793 ILE A CG2 1 
ATOM   4876 C CD1 . ILE A 1 812 ? 0.921   75.227  114.597 1.00 92.22  ? 793 ILE A CD1 1 
ATOM   4877 N N   . PRO A 1 813 ? 2.127   71.683  110.664 1.00 82.40  ? 794 PRO A N   1 
ATOM   4878 C CA  . PRO A 1 813 ? 2.422   71.631  109.260 1.00 74.11  ? 794 PRO A CA  1 
ATOM   4879 C C   . PRO A 1 813 ? 1.340   72.473  108.585 1.00 74.84  ? 794 PRO A C   1 
ATOM   4880 O O   . PRO A 1 813 ? 0.245   72.417  109.001 1.00 72.19  ? 794 PRO A O   1 
ATOM   4881 C CB  . PRO A 1 813 ? 2.210   70.156  108.971 1.00 66.13  ? 794 PRO A CB  1 
ATOM   4882 C CG  . PRO A 1 813 ? 2.226   69.523  110.311 1.00 71.08  ? 794 PRO A CG  1 
ATOM   4883 C CD  . PRO A 1 813 ? 1.443   70.508  111.124 1.00 81.18  ? 794 PRO A CD  1 
ATOM   4884 N N   . ARG A 1 814 ? 1.670   73.181  107.514 1.00 71.81  ? 795 ARG A N   1 
ATOM   4885 C CA  . ARG A 1 814 ? 0.670   74.088  106.919 1.00 71.59  ? 795 ARG A CA  1 
ATOM   4886 C C   . ARG A 1 814 ? 0.394   73.785  105.453 1.00 67.62  ? 795 ARG A C   1 
ATOM   4887 O O   . ARG A 1 814 ? -0.630  74.197  104.982 1.00 64.00  ? 795 ARG A O   1 
ATOM   4888 C CB  . ARG A 1 814 ? 1.220   75.507  107.003 1.00 66.98  ? 795 ARG A CB  1 
ATOM   4889 C CG  . ARG A 1 814 ? 1.496   75.979  108.415 1.00 72.31  ? 795 ARG A CG  1 
ATOM   4890 C CD  . ARG A 1 814 ? 0.224   76.557  108.955 1.00 73.14  ? 795 ARG A CD  1 
ATOM   4891 N NE  . ARG A 1 814 ? 0.338   77.079  110.291 1.00 73.03  ? 795 ARG A NE  1 
ATOM   4892 C CZ  . ARG A 1 814 ? -0.697  77.469  110.987 1.00 69.61  ? 795 ARG A CZ  1 
ATOM   4893 N NH1 . ARG A 1 814 ? -1.901  77.388  110.477 1.00 68.38  ? 795 ARG A NH1 1 
ATOM   4894 N NH2 . ARG A 1 814 ? -0.539  77.944  112.191 1.00 77.53  ? 795 ARG A NH2 1 
ATOM   4895 N N   . LEU A 1 815 ? 1.276   73.077  104.772 1.00 66.55  ? 796 LEU A N   1 
ATOM   4896 C CA  . LEU A 1 815 ? 1.082   72.825  103.328 1.00 62.66  ? 796 LEU A CA  1 
ATOM   4897 C C   . LEU A 1 815 ? 0.871   71.340  103.100 1.00 67.14  ? 796 LEU A C   1 
ATOM   4898 O O   . LEU A 1 815 ? 1.781   70.615  103.384 1.00 65.65  ? 796 LEU A O   1 
ATOM   4899 C CB  . LEU A 1 815 ? 2.368   73.260  102.648 1.00 63.02  ? 796 LEU A CB  1 
ATOM   4900 C CG  . LEU A 1 815 ? 2.291   73.440  101.149 1.00 65.93  ? 796 LEU A CG  1 
ATOM   4901 C CD1 . LEU A 1 815 ? 1.003   74.109  100.777 1.00 65.90  ? 796 LEU A CD1 1 
ATOM   4902 C CD2 . LEU A 1 815 ? 3.459   74.253  100.675 1.00 61.55  ? 796 LEU A CD2 1 
ATOM   4903 N N   . PHE A 1 816 ? -0.280  70.939  102.571 1.00 63.39  ? 797 PHE A N   1 
ATOM   4904 C CA  . PHE A 1 816 ? -0.570  69.509  102.342 1.00 61.40  ? 797 PHE A CA  1 
ATOM   4905 C C   . PHE A 1 816 ? -0.721  69.244  100.856 1.00 66.85  ? 797 PHE A C   1 
ATOM   4906 O O   . PHE A 1 816 ? -1.045  70.138  100.134 1.00 68.39  ? 797 PHE A O   1 
ATOM   4907 C CB  . PHE A 1 816 ? -1.820  69.112  103.103 1.00 65.08  ? 797 PHE A CB  1 
ATOM   4908 C CG  . PHE A 1 816 ? -1.729  69.422  104.564 1.00 65.68  ? 797 PHE A CG  1 
ATOM   4909 C CD1 . PHE A 1 816 ? -1.869  70.704  105.018 1.00 65.99  ? 797 PHE A CD1 1 
ATOM   4910 C CD2 . PHE A 1 816 ? -1.477  68.432  105.478 1.00 68.98  ? 797 PHE A CD2 1 
ATOM   4911 C CE1 . PHE A 1 816 ? -1.772  70.988  106.362 1.00 64.79  ? 797 PHE A CE1 1 
ATOM   4912 C CE2 . PHE A 1 816 ? -1.386  68.722  106.819 1.00 63.41  ? 797 PHE A CE2 1 
ATOM   4913 C CZ  . PHE A 1 816 ? -1.529  69.998  107.258 1.00 63.61  ? 797 PHE A CZ  1 
ATOM   4914 N N   . PHE A 1 817 ? -0.533  68.002  100.448 1.00 69.66  ? 798 PHE A N   1 
ATOM   4915 C CA  . PHE A 1 817 ? -0.541  67.660  99.027  1.00 65.19  ? 798 PHE A CA  1 
ATOM   4916 C C   . PHE A 1 817 ? -1.440  66.476  98.751  1.00 62.22  ? 798 PHE A C   1 
ATOM   4917 O O   . PHE A 1 817 ? -1.250  65.409  99.328  1.00 58.18  ? 798 PHE A O   1 
ATOM   4918 C CB  . PHE A 1 817 ? 0.845   67.316  98.531  1.00 63.24  ? 798 PHE A CB  1 
ATOM   4919 C CG  . PHE A 1 817 ? 1.815   68.401  98.693  1.00 66.90  ? 798 PHE A CG  1 
ATOM   4920 C CD1 . PHE A 1 817 ? 2.521   68.545  99.870  1.00 67.91  ? 798 PHE A CD1 1 
ATOM   4921 C CD2 . PHE A 1 817 ? 2.035   69.282  97.667  1.00 67.14  ? 798 PHE A CD2 1 
ATOM   4922 C CE1 . PHE A 1 817 ? 3.440   69.563  100.008 1.00 69.30  ? 798 PHE A CE1 1 
ATOM   4923 C CE2 . PHE A 1 817 ? 2.945   70.291  97.792  1.00 66.63  ? 798 PHE A CE2 1 
ATOM   4924 C CZ  . PHE A 1 817 ? 3.653   70.440  98.967  1.00 68.26  ? 798 PHE A CZ  1 
ATOM   4925 N N   . ALA A 1 818 ? -2.283  66.637  97.756  1.00 62.23  ? 799 ALA A N   1 
ATOM   4926 C CA  . ALA A 1 818 ? -3.135  65.530  97.306  1.00 65.30  ? 799 ALA A CA  1 
ATOM   4927 C C   . ALA A 1 818 ? -3.057  65.436  95.789  1.00 64.98  ? 799 ALA A C   1 
ATOM   4928 O O   . ALA A 1 818 ? -2.314  66.170  95.185  1.00 59.80  ? 799 ALA A O   1 
ATOM   4929 C CB  . ALA A 1 818 ? -4.531  65.750  97.760  1.00 63.31  ? 799 ALA A CB  1 
ATOM   4930 N N   . GLY A 1 819 ? -3.832  64.541  95.206  1.00 64.37  ? 800 GLY A N   1 
ATOM   4931 C CA  . GLY A 1 819 ? -3.783  64.357  93.750  1.00 68.00  ? 800 GLY A CA  1 
ATOM   4932 C C   . GLY A 1 819 ? -3.259  62.987  93.399  1.00 68.66  ? 800 GLY A C   1 
ATOM   4933 O O   . GLY A 1 819 ? -2.703  62.364  94.255  1.00 65.70  ? 800 GLY A O   1 
ATOM   4934 N N   . GLU A 1 820 ? -3.392  62.574  92.149  1.00 71.20  ? 801 GLU A N   1 
ATOM   4935 C CA  . GLU A 1 820 ? -2.977  61.212  91.757  1.00 60.43  ? 801 GLU A CA  1 
ATOM   4936 C C   . GLU A 1 820 ? -1.490  61.014  91.934  1.00 59.21  ? 801 GLU A C   1 
ATOM   4937 O O   . GLU A 1 820 ? -1.104  59.913  92.068  1.00 67.32  ? 801 GLU A O   1 
ATOM   4938 C CB  . GLU A 1 820 ? -3.309  60.905  90.308  1.00 64.70  ? 801 GLU A CB  1 
ATOM   4939 C CG  . GLU A 1 820 ? -3.025  62.029  89.370  1.00 64.40  ? 801 GLU A CG  1 
ATOM   4940 C CD  . GLU A 1 820 ? -1.696  61.917  88.687  1.00 66.32  ? 801 GLU A CD  1 
ATOM   4941 O OE1 . GLU A 1 820 ? -1.035  60.940  88.897  1.00 64.35  ? 801 GLU A OE1 1 
ATOM   4942 O OE2 . GLU A 1 820 ? -1.357  62.819  87.967  1.00 72.05  ? 801 GLU A OE2 1 
ATOM   4943 N N   . HIS A 1 821 ? -0.697  62.052  92.078  1.00 59.43  ? 802 HIS A N   1 
ATOM   4944 C CA  . HIS A 1 821 ? 0.751   61.771  92.172  1.00 62.24  ? 802 HIS A CA  1 
ATOM   4945 C C   . HIS A 1 821 ? 1.178   61.553  93.613  1.00 65.62  ? 802 HIS A C   1 
ATOM   4946 O O   . HIS A 1 821 ? 2.355   61.442  93.830  1.00 67.33  ? 802 HIS A O   1 
ATOM   4947 C CB  . HIS A 1 821 ? 1.551   62.883  91.528  1.00 60.86  ? 802 HIS A CB  1 
ATOM   4948 C CG  . HIS A 1 821 ? 1.124   64.208  92.012  1.00 62.09  ? 802 HIS A CG  1 
ATOM   4949 N ND1 . HIS A 1 821 ? -0.074  64.726  91.698  1.00 70.22  ? 802 HIS A ND1 1 
ATOM   4950 C CD2 . HIS A 1 821 ? 1.728   65.099  92.798  1.00 61.39  ? 802 HIS A CD2 1 
ATOM   4951 C CE1 . HIS A 1 821 ? -0.201  65.888  92.270  1.00 70.57  ? 802 HIS A CE1 1 
ATOM   4952 N NE2 . HIS A 1 821 ? 0.879   66.131  92.952  1.00 65.79  ? 802 HIS A NE2 1 
ATOM   4953 N N   . THR A 1 822 ? 0.255   61.586  94.557  1.00 60.38  ? 803 THR A N   1 
ATOM   4954 C CA  . THR A 1 822 ? 0.610   61.421  95.970  1.00 67.40  ? 803 THR A CA  1 
ATOM   4955 C C   . THR A 1 822 ? 0.236   60.034  96.466  1.00 69.56  ? 803 THR A C   1 
ATOM   4956 O O   . THR A 1 822 ? 0.753   59.622  97.474  1.00 77.26  ? 803 THR A O   1 
ATOM   4957 C CB  . THR A 1 822 ? -0.164  62.473  96.745  1.00 69.52  ? 803 THR A CB  1 
ATOM   4958 O OG1 . THR A 1 822 ? -1.502  62.119  96.452  1.00 65.44  ? 803 THR A OG1 1 
ATOM   4959 C CG2 . THR A 1 822 ? 0.055   63.843  96.173  1.00 61.05  ? 803 THR A CG2 1 
ATOM   4960 N N   . ILE A 1 823 ? -0.581  59.307  95.736  1.00 64.42  ? 804 ILE A N   1 
ATOM   4961 C CA  . ILE A 1 823 ? -1.003  58.000  96.284  1.00 60.31  ? 804 ILE A CA  1 
ATOM   4962 C C   . ILE A 1 823 ? -0.242  56.889  95.581  1.00 66.95  ? 804 ILE A C   1 
ATOM   4963 O O   . ILE A 1 823 ? -0.662  56.443  94.554  1.00 64.02  ? 804 ILE A O   1 
ATOM   4964 C CB  . ILE A 1 823 ? -2.519  57.919  96.156  1.00 58.88  ? 804 ILE A CB  1 
ATOM   4965 C CG1 . ILE A 1 823 ? -3.117  56.788  96.971  1.00 58.34  ? 804 ILE A CG1 1 
ATOM   4966 C CG2 . ILE A 1 823 ? -2.937  57.882  94.718  1.00 54.71  ? 804 ILE A CG2 1 
ATOM   4967 C CD1 . ILE A 1 823 ? -4.574  56.944  97.166  1.00 54.77  ? 804 ILE A CD1 1 
ATOM   4968 N N   . ARG A 1 824 ? 0.752   56.369  96.274  1.00 70.82  ? 805 ARG A N   1 
ATOM   4969 C CA  . ARG A 1 824 ? 1.721   55.374  95.784  1.00 63.58  ? 805 ARG A CA  1 
ATOM   4970 C C   . ARG A 1 824 ? 1.054   54.080  95.379  1.00 65.61  ? 805 ARG A C   1 
ATOM   4971 O O   . ARG A 1 824 ? 1.522   53.465  94.460  1.00 69.01  ? 805 ARG A O   1 
ATOM   4972 C CB  . ARG A 1 824 ? 2.624   55.001  96.950  1.00 64.74  ? 805 ARG A CB  1 
ATOM   4973 C CG  . ARG A 1 824 ? 3.208   53.609  96.859  1.00 67.14  ? 805 ARG A CG  1 
ATOM   4974 C CD  . ARG A 1 824 ? 3.977   53.262  98.101  1.00 64.15  ? 805 ARG A CD  1 
ATOM   4975 N NE  . ARG A 1 824 ? 5.095   52.419  97.769  1.00 66.60  ? 805 ARG A NE  1 
ATOM   4976 C CZ  . ARG A 1 824 ? 6.256   52.475  98.374  1.00 72.51  ? 805 ARG A CZ  1 
ATOM   4977 N NH1 . ARG A 1 824 ? 6.447   53.331  99.350  1.00 73.92  ? 805 ARG A NH1 1 
ATOM   4978 N NH2 . ARG A 1 824 ? 7.231   51.677  98.013  1.00 82.04  ? 805 ARG A NH2 1 
ATOM   4979 N N   . ASN A 1 825 ? -0.032  53.717  96.016  1.00 70.73  ? 806 ASN A N   1 
ATOM   4980 C CA  . ASN A 1 825 ? -0.611  52.403  95.687  1.00 67.34  ? 806 ASN A CA  1 
ATOM   4981 C C   . ASN A 1 825 ? -1.663  52.521  94.607  1.00 65.23  ? 806 ASN A C   1 
ATOM   4982 O O   . ASN A 1 825 ? -2.153  51.508  94.201  1.00 71.36  ? 806 ASN A O   1 
ATOM   4983 C CB  . ASN A 1 825 ? -1.280  51.811  96.913  1.00 64.99  ? 806 ASN A CB  1 
ATOM   4984 C CG  . ASN A 1 825 ? -0.257  51.253  97.861  1.00 73.39  ? 806 ASN A CG  1 
ATOM   4985 O OD1 . ASN A 1 825 ? 0.920   51.277  97.563  1.00 75.61  ? 806 ASN A OD1 1 
ATOM   4986 N ND2 . ASN A 1 825 ? -0.696  50.728  98.981  1.00 66.60  ? 806 ASN A ND2 1 
ATOM   4987 N N   . TYR A 1 826 ? -2.110  53.717  94.264  1.00 57.14  ? 807 TYR A N   1 
ATOM   4988 C CA  . TYR A 1 826 ? -3.195  53.820  93.262  1.00 61.34  ? 807 TYR A CA  1 
ATOM   4989 C C   . TYR A 1 826 ? -2.953  55.027  92.371  1.00 63.29  ? 807 TYR A C   1 
ATOM   4990 O O   . TYR A 1 826 ? -3.877  55.726  92.077  1.00 63.27  ? 807 TYR A O   1 
ATOM   4991 C CB  . TYR A 1 826 ? -4.568  53.985  93.923  1.00 59.01  ? 807 TYR A CB  1 
ATOM   4992 C CG  . TYR A 1 826 ? -4.994  52.875  94.843  1.00 68.35  ? 807 TYR A CG  1 
ATOM   4993 C CD1 . TYR A 1 826 ? -5.685  51.780  94.387  1.00 73.39  ? 807 TYR A CD1 1 
ATOM   4994 C CD2 . TYR A 1 826 ? -4.635  52.889  96.167  1.00 65.89  ? 807 TYR A CD2 1 
ATOM   4995 C CE1 . TYR A 1 826 ? -6.030  50.745  95.231  1.00 75.40  ? 807 TYR A CE1 1 
ATOM   4996 C CE2 . TYR A 1 826 ? -4.960  51.861  97.023  1.00 71.27  ? 807 TYR A CE2 1 
ATOM   4997 C CZ  . TYR A 1 826 ? -5.669  50.788  96.555  1.00 75.38  ? 807 TYR A CZ  1 
ATOM   4998 O OH  . TYR A 1 826 ? -5.982  49.790  97.413  1.00 75.62  ? 807 TYR A OH  1 
ATOM   4999 N N   . PRO A 1 827 ? -1.747  55.266  91.852  1.00 60.24  ? 808 PRO A N   1 
ATOM   5000 C CA  . PRO A 1 827 ? -1.499  56.422  91.045  1.00 60.36  ? 808 PRO A CA  1 
ATOM   5001 C C   . PRO A 1 827 ? -2.158  56.474  89.675  1.00 63.71  ? 808 PRO A C   1 
ATOM   5002 O O   . PRO A 1 827 ? -2.669  55.537  89.225  1.00 68.21  ? 808 PRO A O   1 
ATOM   5003 C CB  . PRO A 1 827 ? 0.003   56.404  90.837  1.00 58.94  ? 808 PRO A CB  1 
ATOM   5004 C CG  . PRO A 1 827 ? 0.360   54.995  91.009  1.00 58.29  ? 808 PRO A CG  1 
ATOM   5005 C CD  . PRO A 1 827 ? -0.561  54.509  92.090  1.00 62.36  ? 808 PRO A CD  1 
ATOM   5006 N N   . ALA A 1 828 ? -2.142  57.660  89.106  1.00 62.52  ? 809 ALA A N   1 
ATOM   5007 C CA  . ALA A 1 828 ? -2.671  57.956  87.770  1.00 62.89  ? 809 ALA A CA  1 
ATOM   5008 C C   . ALA A 1 828 ? -4.060  57.383  87.579  1.00 66.93  ? 809 ALA A C   1 
ATOM   5009 O O   . ALA A 1 828 ? -4.295  56.807  86.569  1.00 80.10  ? 809 ALA A O   1 
ATOM   5010 C CB  . ALA A 1 828 ? -1.738  57.391  86.761  1.00 69.82  ? 809 ALA A CB  1 
ATOM   5011 N N   . THR A 1 829 ? -4.965  57.576  88.512  1.00 69.85  ? 810 THR A N   1 
ATOM   5012 C CA  . THR A 1 829 ? -6.326  57.044  88.317  1.00 73.18  ? 810 THR A CA  1 
ATOM   5013 C C   . THR A 1 829 ? -7.301  57.981  88.997  1.00 70.45  ? 810 THR A C   1 
ATOM   5014 O O   . THR A 1 829 ? -6.915  58.625  89.920  1.00 71.07  ? 810 THR A O   1 
ATOM   5015 C CB  . THR A 1 829 ? -6.525  55.772  89.118  1.00 68.57  ? 810 THR A CB  1 
ATOM   5016 O OG1 . THR A 1 829 ? -6.069  56.132  90.411  1.00 68.39  ? 810 THR A OG1 1 
ATOM   5017 C CG2 . THR A 1 829 ? -5.706  54.616  88.613  1.00 73.05  ? 810 THR A CG2 1 
ATOM   5018 N N   . VAL A 1 830 ? -8.554  57.982  88.598  1.00 67.53  ? 811 VAL A N   1 
ATOM   5019 C CA  . VAL A 1 830 ? -9.459  58.918  89.299  1.00 63.64  ? 811 VAL A CA  1 
ATOM   5020 C C   . VAL A 1 830 ? -9.629  58.428  90.720  1.00 65.21  ? 811 VAL A C   1 
ATOM   5021 O O   . VAL A 1 830 ? -9.552  59.210  91.605  1.00 70.63  ? 811 VAL A O   1 
ATOM   5022 C CB  . VAL A 1 830 ? -10.816 59.039  88.614  1.00 63.56  ? 811 VAL A CB  1 
ATOM   5023 C CG1 . VAL A 1 830 ? -11.861 59.372  89.637  1.00 61.44  ? 811 VAL A CG1 1 
ATOM   5024 C CG2 . VAL A 1 830 ? -10.789 60.103  87.551  1.00 67.59  ? 811 VAL A CG2 1 
ATOM   5025 N N   . HIS A 1 831 ? -9.755  57.136  90.932  1.00 67.68  ? 812 HIS A N   1 
ATOM   5026 C CA  . HIS A 1 831 ? -9.958  56.662  92.315  1.00 70.91  ? 812 HIS A CA  1 
ATOM   5027 C C   . HIS A 1 831 ? -8.742  56.996  93.165  1.00 72.75  ? 812 HIS A C   1 
ATOM   5028 O O   . HIS A 1 831 ? -8.914  57.345  94.290  1.00 69.38  ? 812 HIS A O   1 
ATOM   5029 C CB  . HIS A 1 831 ? -10.312 55.183  92.316  1.00 70.68  ? 812 HIS A CB  1 
ATOM   5030 C CG  . HIS A 1 831 ? -9.349  54.327  91.580  1.00 73.85  ? 812 HIS A CG  1 
ATOM   5031 N ND1 . HIS A 1 831 ? -8.308  53.725  92.196  1.00 68.56  ? 812 HIS A ND1 1 
ATOM   5032 C CD2 . HIS A 1 831 ? -9.285  53.955  90.300  1.00 69.32  ? 812 HIS A CD2 1 
ATOM   5033 C CE1 . HIS A 1 831 ? -7.629  53.031  91.332  1.00 68.65  ? 812 HIS A CE1 1 
ATOM   5034 N NE2 . HIS A 1 831 ? -8.200  53.157  90.177  1.00 73.35  ? 812 HIS A NE2 1 
ATOM   5035 N N   . GLY A 1 832 ? -7.546  56.888  92.627  1.00 75.80  ? 813 GLY A N   1 
ATOM   5036 C CA  . GLY A 1 832 ? -6.372  57.234  93.429  1.00 70.54  ? 813 GLY A CA  1 
ATOM   5037 C C   . GLY A 1 832 ? -6.443  58.668  93.855  1.00 65.06  ? 813 GLY A C   1 
ATOM   5038 O O   . GLY A 1 832 ? -6.158  58.924  94.976  1.00 61.89  ? 813 GLY A O   1 
ATOM   5039 N N   . ALA A 1 833 ? -6.769  59.555  92.936  1.00 61.75  ? 814 ALA A N   1 
ATOM   5040 C CA  . ALA A 1 833 ? -6.883  60.983  93.247  1.00 62.87  ? 814 ALA A CA  1 
ATOM   5041 C C   . ALA A 1 833 ? -7.847  61.112  94.402  1.00 64.32  ? 814 ALA A C   1 
ATOM   5042 O O   . ALA A 1 833 ? -7.462  61.614  95.439  1.00 61.92  ? 814 ALA A O   1 
ATOM   5043 C CB  . ALA A 1 833 ? -7.458  61.662  92.055  1.00 64.07  ? 814 ALA A CB  1 
ATOM   5044 N N   . LEU A 1 834 ? -9.052  60.629  94.176  1.00 64.60  ? 815 LEU A N   1 
ATOM   5045 C CA  . LEU A 1 834 ? -10.085 60.678  95.192  1.00 62.25  ? 815 LEU A CA  1 
ATOM   5046 C C   . LEU A 1 834 ? -9.597  60.131  96.527  1.00 62.66  ? 815 LEU A C   1 
ATOM   5047 O O   . LEU A 1 834 ? -9.810  60.748  97.574  1.00 64.50  ? 815 LEU A O   1 
ATOM   5048 C CB  . LEU A 1 834 ? -11.294 59.909  94.706  1.00 59.13  ? 815 LEU A CB  1 
ATOM   5049 C CG  . LEU A 1 834 ? -12.460 59.871  95.669  1.00 58.72  ? 815 LEU A CG  1 
ATOM   5050 C CD1 . LEU A 1 834 ? -13.737 59.962  94.849  1.00 66.41  ? 815 LEU A CD1 1 
ATOM   5051 C CD2 . LEU A 1 834 ? -12.433 58.602  96.482  1.00 59.48  ? 815 LEU A CD2 1 
ATOM   5052 N N   . LEU A 1 835 ? -8.937  58.980  96.531  1.00 63.15  ? 816 LEU A N   1 
ATOM   5053 C CA  . LEU A 1 835 ? -8.511  58.501  97.835  1.00 66.15  ? 816 LEU A CA  1 
ATOM   5054 C C   . LEU A 1 835 ? -7.532  59.466  98.473  1.00 65.73  ? 816 LEU A C   1 
ATOM   5055 O O   . LEU A 1 835 ? -7.497  59.573  99.704  1.00 67.93  ? 816 LEU A O   1 
ATOM   5056 C CB  . LEU A 1 835 ? -7.892  57.113  97.789  1.00 62.15  ? 816 LEU A CB  1 
ATOM   5057 C CG  . LEU A 1 835 ? -8.784  55.951  97.419  1.00 64.18  ? 816 LEU A CG  1 
ATOM   5058 C CD1 . LEU A 1 835 ? -7.976  54.678  97.531  1.00 73.71  ? 816 LEU A CD1 1 
ATOM   5059 C CD2 . LEU A 1 835 ? -9.998  55.896  98.268  1.00 66.87  ? 816 LEU A CD2 1 
ATOM   5060 N N   . SER A 1 836 ? -6.741  60.189  97.667  1.00 61.25  ? 817 SER A N   1 
ATOM   5061 C CA  . SER A 1 836 ? -5.734  61.042  98.285  1.00 61.93  ? 817 SER A CA  1 
ATOM   5062 C C   . SER A 1 836 ? -6.381  62.286  98.876  1.00 63.20  ? 817 SER A C   1 
ATOM   5063 O O   . SER A 1 836 ? -5.969  62.747  99.947  1.00 61.86  ? 817 SER A O   1 
ATOM   5064 C CB  . SER A 1 836 ? -4.626  61.381  97.277  1.00 60.97  ? 817 SER A CB  1 
ATOM   5065 O OG  . SER A 1 836 ? -5.040  62.308  96.306  1.00 63.77  ? 817 SER A OG  1 
ATOM   5066 N N   . GLY A 1 837 ? -7.426  62.797  98.226  1.00 65.66  ? 818 GLY A N   1 
ATOM   5067 C CA  . GLY A 1 837 ? -8.214  63.857  98.830  1.00 64.98  ? 818 GLY A CA  1 
ATOM   5068 C C   . GLY A 1 837 ? -8.837  63.429  100.147 1.00 64.13  ? 818 GLY A C   1 
ATOM   5069 O O   . GLY A 1 837 ? -8.730  64.129  101.149 1.00 67.16  ? 818 GLY A O   1 
ATOM   5070 N N   . LEU A 1 838 ? -9.505  62.277  100.159 1.00 64.43  ? 819 LEU A N   1 
ATOM   5071 C CA  . LEU A 1 838 ? -10.004 61.755  101.421 1.00 58.44  ? 819 LEU A CA  1 
ATOM   5072 C C   . LEU A 1 838 ? -8.880  61.674  102.431 1.00 61.30  ? 819 LEU A C   1 
ATOM   5073 O O   . LEU A 1 838 ? -9.063  62.002  103.608 1.00 67.56  ? 819 LEU A O   1 
ATOM   5074 C CB  . LEU A 1 838 ? -10.618 60.374  101.226 1.00 63.90  ? 819 LEU A CB  1 
ATOM   5075 C CG  . LEU A 1 838 ? -11.860 60.225  100.357 1.00 66.97  ? 819 LEU A CG  1 
ATOM   5076 C CD1 . LEU A 1 838 ? -12.540 58.893  100.630 1.00 69.15  ? 819 LEU A CD1 1 
ATOM   5077 C CD2 . LEU A 1 838 ? -12.810 61.381  100.580 1.00 68.68  ? 819 LEU A CD2 1 
ATOM   5078 N N   . ARG A 1 839 ? -7.724  61.232  101.994 1.00 60.17  ? 820 ARG A N   1 
ATOM   5079 C CA  . ARG A 1 839 ? -6.626  61.021  102.952 1.00 56.45  ? 820 ARG A CA  1 
ATOM   5080 C C   . ARG A 1 839 ? -6.166  62.327  103.561 1.00 60.68  ? 820 ARG A C   1 
ATOM   5081 O O   . ARG A 1 839 ? -6.031  62.385  104.744 1.00 62.59  ? 820 ARG A O   1 
ATOM   5082 C CB  . ARG A 1 839 ? -5.428  60.425  102.235 1.00 54.19  ? 820 ARG A CB  1 
ATOM   5083 C CG  . ARG A 1 839 ? -4.202  60.362  103.114 1.00 49.23  ? 820 ARG A CG  1 
ATOM   5084 C CD  . ARG A 1 839 ? -3.002  60.096  102.265 1.00 61.03  ? 820 ARG A CD  1 
ATOM   5085 N NE  . ARG A 1 839 ? -2.642  61.270  101.519 1.00 65.45  ? 820 ARG A NE  1 
ATOM   5086 C CZ  . ARG A 1 839 ? -2.252  61.219  100.279 1.00 63.73  ? 820 ARG A CZ  1 
ATOM   5087 N NH1 . ARG A 1 839 ? -2.190  60.063  99.672  1.00 65.72  ? 820 ARG A NH1 1 
ATOM   5088 N NH2 . ARG A 1 839 ? -1.931  62.307  99.640  1.00 69.87  ? 820 ARG A NH2 1 
ATOM   5089 N N   . GLU A 1 840 ? -5.917  63.338  102.760 1.00 63.21  ? 821 GLU A N   1 
ATOM   5090 C CA  . GLU A 1 840 ? -5.384  64.577  103.354 1.00 62.88  ? 821 GLU A CA  1 
ATOM   5091 C C   . GLU A 1 840 ? -6.442  65.210  104.231 1.00 66.81  ? 821 GLU A C   1 
ATOM   5092 O O   . GLU A 1 840 ? -6.069  65.750  105.236 1.00 70.29  ? 821 GLU A O   1 
ATOM   5093 C CB  . GLU A 1 840 ? -4.942  65.568  102.295 1.00 61.29  ? 821 GLU A CB  1 
ATOM   5094 C CG  . GLU A 1 840 ? -3.696  65.152  101.568 1.00 69.99  ? 821 GLU A CG  1 
ATOM   5095 C CD  . GLU A 1 840 ? -2.510  64.829  102.435 1.00 69.99  ? 821 GLU A CD  1 
ATOM   5096 O OE1 . GLU A 1 840 ? -2.700  64.265  103.457 1.00 76.39  ? 821 GLU A OE1 1 
ATOM   5097 O OE2 . GLU A 1 840 ? -1.413  65.131  102.059 1.00 78.40  ? 821 GLU A OE2 1 
ATOM   5098 N N   . ALA A 1 841 ? -7.693  65.181  103.811 1.00 62.40  ? 822 ALA A N   1 
ATOM   5099 C CA  . ALA A 1 841 ? -8.767  65.792  104.608 1.00 64.03  ? 822 ALA A CA  1 
ATOM   5100 C C   . ALA A 1 841 ? -8.706  65.214  106.003 1.00 64.94  ? 822 ALA A C   1 
ATOM   5101 O O   . ALA A 1 841 ? -8.592  65.964  106.915 1.00 69.90  ? 822 ALA A O   1 
ATOM   5102 C CB  . ALA A 1 841 ? -10.087 65.505  103.983 1.00 61.77  ? 822 ALA A CB  1 
ATOM   5103 N N   . GLY A 1 842 ? -8.688  63.908  106.126 1.00 65.47  ? 823 GLY A N   1 
ATOM   5104 C CA  . GLY A 1 842 ? -8.589  63.344  107.476 1.00 71.01  ? 823 GLY A CA  1 
ATOM   5105 C C   . GLY A 1 842 ? -7.331  63.777  108.187 1.00 67.52  ? 823 GLY A C   1 
ATOM   5106 O O   . GLY A 1 842 ? -7.386  63.994  109.366 1.00 71.29  ? 823 GLY A O   1 
ATOM   5107 N N   . ARG A 1 843 ? -6.216  63.891  107.496 1.00 64.51  ? 824 ARG A N   1 
ATOM   5108 C CA  . ARG A 1 843 ? -4.979  64.274  108.197 1.00 69.20  ? 824 ARG A CA  1 
ATOM   5109 C C   . ARG A 1 843 ? -5.030  65.749  108.549 1.00 71.12  ? 824 ARG A C   1 
ATOM   5110 O O   . ARG A 1 843 ? -4.436  66.123  109.522 1.00 70.86  ? 824 ARG A O   1 
ATOM   5111 C CB  . ARG A 1 843 ? -3.780  63.945  107.321 1.00 57.45  ? 824 ARG A CB  1 
ATOM   5112 C CG  . ARG A 1 843 ? -2.879  65.126  107.059 1.00 60.96  ? 824 ARG A CG  1 
ATOM   5113 C CD  . ARG A 1 843 ? -1.480  64.592  107.004 1.00 69.82  ? 824 ARG A CD  1 
ATOM   5114 N NE  . ARG A 1 843 ? -1.251  63.872  105.780 1.00 81.18  ? 824 ARG A NE  1 
ATOM   5115 C CZ  . ARG A 1 843 ? -0.201  63.112  105.597 1.00 78.19  ? 824 ARG A CZ  1 
ATOM   5116 N NH1 . ARG A 1 843 ? 0.675   62.987  106.565 1.00 83.26  ? 824 ARG A NH1 1 
ATOM   5117 N NH2 . ARG A 1 843 ? -0.022  62.480  104.467 1.00 74.35  ? 824 ARG A NH2 1 
ATOM   5118 N N   . ILE A 1 844 ? -5.710  66.553  107.755 1.00 72.99  ? 825 ILE A N   1 
ATOM   5119 C CA  . ILE A 1 844 ? -5.791  67.997  108.086 1.00 73.53  ? 825 ILE A CA  1 
ATOM   5120 C C   . ILE A 1 844 ? -6.743  68.131  109.258 1.00 71.02  ? 825 ILE A C   1 
ATOM   5121 O O   . ILE A 1 844 ? -6.397  68.767  110.209 1.00 75.37  ? 825 ILE A O   1 
ATOM   5122 C CB  . ILE A 1 844 ? -6.279  68.791  106.874 1.00 74.08  ? 825 ILE A CB  1 
ATOM   5123 C CG1 . ILE A 1 844 ? -5.155  69.003  105.869 1.00 66.19  ? 825 ILE A CG1 1 
ATOM   5124 C CG2 . ILE A 1 844 ? -6.886  70.096  107.307 1.00 62.87  ? 825 ILE A CG2 1 
ATOM   5125 C CD1 . ILE A 1 844 ? -5.618  69.594  104.590 1.00 61.13  ? 825 ILE A CD1 1 
ATOM   5126 N N   . ALA A 1 845 ? -7.857  67.423  109.222 1.00 69.18  ? 826 ALA A N   1 
ATOM   5127 C CA  . ALA A 1 845 ? -8.850  67.481  110.311 1.00 74.66  ? 826 ALA A CA  1 
ATOM   5128 C C   . ALA A 1 845 ? -8.190  67.086  111.619 1.00 72.86  ? 826 ALA A C   1 
ATOM   5129 O O   . ALA A 1 845 ? -8.318  67.788  112.580 1.00 73.91  ? 826 ALA A O   1 
ATOM   5130 C CB  . ALA A 1 845 ? -9.968  66.546  109.998 1.00 74.00  ? 826 ALA A CB  1 
ATOM   5131 N N   . ASP A 1 846 ? -7.399  66.028  111.598 1.00 74.13  ? 827 ASP A N   1 
ATOM   5132 C CA  . ASP A 1 846 ? -6.653  65.540  112.774 1.00 77.82  ? 827 ASP A CA  1 
ATOM   5133 C C   . ASP A 1 846 ? -5.688  66.605  113.303 1.00 78.34  ? 827 ASP A C   1 
ATOM   5134 O O   . ASP A 1 846 ? -5.388  66.558  114.466 1.00 84.71  ? 827 ASP A O   1 
ATOM   5135 C CB  . ASP A 1 846 ? -5.827  64.316  112.390 1.00 80.97  ? 827 ASP A CB  1 
ATOM   5136 C CG  . ASP A 1 846 ? -6.558  62.992  112.426 1.00 86.28  ? 827 ASP A CG  1 
ATOM   5137 O OD1 . ASP A 1 846 ? -7.774  63.000  112.425 1.00 84.33  ? 827 ASP A OD1 1 
ATOM   5138 O OD2 . ASP A 1 846 ? -5.886  61.967  112.449 1.00 85.11  ? 827 ASP A OD2 1 
ATOM   5139 N N   . GLN A 1 847 ? -5.154  67.493  112.482 1.00 74.13  ? 828 GLN A N   1 
ATOM   5140 C CA  . GLN A 1 847 ? -4.196  68.477  113.006 1.00 73.38  ? 828 GLN A CA  1 
ATOM   5141 C C   . GLN A 1 847 ? -4.883  69.746  113.473 1.00 76.45  ? 828 GLN A C   1 
ATOM   5142 O O   . GLN A 1 847 ? -4.311  70.403  114.287 1.00 82.12  ? 828 GLN A O   1 
ATOM   5143 C CB  . GLN A 1 847 ? -3.300  68.928  111.870 1.00 79.53  ? 828 GLN A CB  1 
ATOM   5144 C CG  . GLN A 1 847 ? -2.199  69.854  112.324 1.00 81.59  ? 828 GLN A CG  1 
ATOM   5145 C CD  . GLN A 1 847 ? -1.128  69.009  112.946 1.00 102.48 ? 828 GLN A CD  1 
ATOM   5146 O OE1 . GLN A 1 847 ? -0.741  67.985  112.402 1.00 103.63 ? 828 GLN A OE1 1 
ATOM   5147 N NE2 . GLN A 1 847 ? -0.677  69.407  114.120 1.00 101.09 ? 828 GLN A NE2 1 
ATOM   5148 N N   . PHE A 1 848 ? -6.062  70.070  112.972 1.00 77.02  ? 829 PHE A N   1 
ATOM   5149 C CA  . PHE A 1 848 ? -6.664  71.352  113.302 1.00 72.98  ? 829 PHE A CA  1 
ATOM   5150 C C   . PHE A 1 848 ? -7.963  71.224  114.060 1.00 77.67  ? 829 PHE A C   1 
ATOM   5151 O O   . PHE A 1 848 ? -8.341  72.161  114.768 1.00 83.68  ? 829 PHE A O   1 
ATOM   5152 C CB  . PHE A 1 848 ? -6.897  72.175  112.029 1.00 67.80  ? 829 PHE A CB  1 
ATOM   5153 C CG  . PHE A 1 848 ? -5.630  72.649  111.400 1.00 70.08  ? 829 PHE A CG  1 
ATOM   5154 C CD1 . PHE A 1 848 ? -4.985  71.890  110.458 1.00 70.59  ? 829 PHE A CD1 1 
ATOM   5155 C CD2 . PHE A 1 848 ? -5.047  73.835  111.795 1.00 74.55  ? 829 PHE A CD2 1 
ATOM   5156 C CE1 . PHE A 1 848 ? -3.790  72.330  109.907 1.00 75.91  ? 829 PHE A CE1 1 
ATOM   5157 C CE2 . PHE A 1 848 ? -3.853  74.288  111.239 1.00 68.02  ? 829 PHE A CE2 1 
ATOM   5158 C CZ  . PHE A 1 848 ? -3.230  73.543  110.303 1.00 73.19  ? 829 PHE A CZ  1 
ATOM   5159 N N   . LEU A 1 849 ? -8.641  70.091  113.945 1.00 77.04  ? 830 LEU A N   1 
ATOM   5160 C CA  . LEU A 1 849 ? -9.775  69.787  114.798 1.00 75.63  ? 830 LEU A CA  1 
ATOM   5161 C C   . LEU A 1 849 ? -9.425  68.808  115.906 1.00 80.31  ? 830 LEU A C   1 
ATOM   5162 O O   . LEU A 1 849 ? -10.270 68.548  116.765 1.00 89.65  ? 830 LEU A O   1 
ATOM   5163 C CB  . LEU A 1 849 ? -10.919 69.221  113.965 1.00 71.66  ? 830 LEU A CB  1 
ATOM   5164 C CG  . LEU A 1 849 ? -11.254 70.072  112.753 1.00 76.23  ? 830 LEU A CG  1 
ATOM   5165 C CD1 . LEU A 1 849 ? -12.518 69.542  112.093 1.00 77.07  ? 830 LEU A CD1 1 
ATOM   5166 C CD2 . LEU A 1 849 ? -11.394 71.548  113.134 1.00 71.39  ? 830 LEU A CD2 1 
ATOM   5167 N N   . GLY A 1 850 ? -8.212  68.254  115.905 1.00 77.63  ? 831 GLY A N   1 
ATOM   5168 C CA  . GLY A 1 850 ? -7.805  67.312  116.928 1.00 81.34  ? 831 GLY A CA  1 
ATOM   5169 C C   . GLY A 1 850 ? -8.456  65.954  116.781 1.00 89.89  ? 831 GLY A C   1 
ATOM   5170 O O   . GLY A 1 850 ? -9.628  65.844  116.394 1.00 90.24  ? 831 GLY A O   1 
ATOM   5171 N N   . ALA A 1 851 ? -7.698  64.909  117.100 1.00 94.49  ? 832 ALA A N   1 
ATOM   5172 C CA  . ALA A 1 851 ? -8.131  63.527  116.894 1.00 98.59  ? 832 ALA A CA  1 
ATOM   5173 C C   . ALA A 1 851 ? -8.500  62.918  118.247 1.00 104.80 ? 832 ALA A C   1 
ATOM   5174 O O   . ALA A 1 851 ? -7.638  62.400  118.966 1.00 105.50 ? 832 ALA A O   1 
ATOM   5175 C CB  . ALA A 1 851 ? -7.035  62.732  116.188 1.00 89.34  ? 832 ALA A CB  1 
ATOM   5176 N N   . MET A 1 852 ? -9.796  62.956  118.580 1.00 104.00 ? 833 MET A N   1 
ATOM   5177 C CA  . MET A 1 852 ? -10.250 62.540  119.908 1.00 112.99 ? 833 MET A CA  1 
ATOM   5178 C C   . MET A 1 852 ? -10.314 61.016  120.083 1.00 110.20 ? 833 MET A C   1 
ATOM   5179 O O   . MET A 1 852 ? -10.343 60.535  121.227 1.00 109.65 ? 833 MET A O   1 
ATOM   5180 C CB  . MET A 1 852 ? -11.616 63.181  120.195 1.00 118.27 ? 833 MET A CB  1 
ATOM   5181 C CG  . MET A 1 852 ? -11.709 64.683  119.797 1.00 121.58 ? 833 MET A CG  1 
ATOM   5182 S SD  . MET A 1 852 ? -10.598 65.845  120.673 1.00 135.12 ? 833 MET A SD  1 
ATOM   5183 C CE  . MET A 1 852 ? -11.250 67.455  120.195 1.00 103.55 ? 833 MET A CE  1 
ATOM   5184 N N   . TYR A 1 853 ? -10.300 60.249  118.982 1.00 104.56 ? 834 TYR A N   1 
ATOM   5185 C CA  . TYR A 1 853 ? -10.408 58.789  118.960 1.00 104.87 ? 834 TYR A CA  1 
ATOM   5186 C C   . TYR A 1 853 ? -9.068  58.058  119.263 1.00 102.07 ? 834 TYR A C   1 
ATOM   5187 O O   . TYR A 1 853 ? -8.936  56.859  118.957 1.00 92.45  ? 834 TYR A O   1 
ATOM   5188 C CB  . TYR A 1 853 ? -10.959 58.331  117.600 1.00 102.39 ? 834 TYR A CB  1 
ATOM   5189 C CG  . TYR A 1 853 ? -10.279 58.990  116.403 1.00 105.70 ? 834 TYR A CG  1 
ATOM   5190 C CD1 . TYR A 1 853 ? -10.631 60.282  115.993 1.00 99.78  ? 834 TYR A CD1 1 
ATOM   5191 C CD2 . TYR A 1 853 ? -9.267  58.323  115.697 1.00 98.51  ? 834 TYR A CD2 1 
ATOM   5192 C CE1 . TYR A 1 853 ? -9.997  60.881  114.919 1.00 94.22  ? 834 TYR A CE1 1 
ATOM   5193 C CE2 . TYR A 1 853 ? -8.632  58.912  114.621 1.00 93.31  ? 834 TYR A CE2 1 
ATOM   5194 C CZ  . TYR A 1 853 ? -9.000  60.186  114.233 1.00 96.34  ? 834 TYR A CZ  1 
ATOM   5195 O OH  . TYR A 1 853 ? -8.352  60.756  113.159 1.00 93.35  ? 834 TYR A OH  1 
ATOM   5196 N N   . THR A 1 854 ? -8.087  58.734  119.865 1.00 103.21 ? 835 THR A N   1 
ATOM   5197 C CA  . THR A 1 854 ? -6.815  58.103  120.196 1.00 106.14 ? 835 THR A CA  1 
ATOM   5198 C C   . THR A 1 854 ? -6.722  57.648  121.660 1.00 116.37 ? 835 THR A C   1 
ATOM   5199 O O   . THR A 1 854 ? -5.914  56.754  121.959 1.00 113.15 ? 835 THR A O   1 
ATOM   5200 C CB  . THR A 1 854 ? -5.662  59.064  119.836 1.00 111.43 ? 835 THR A CB  1 
ATOM   5201 O OG1 . THR A 1 854 ? -5.760  59.400  118.442 1.00 103.24 ? 835 THR A OG1 1 
ATOM   5202 C CG2 . THR A 1 854 ? -4.253  58.447  120.120 1.00 101.20 ? 835 THR A CG2 1 
ATOM   5203 N N   . LEU A 1 855 ? -7.549  58.195  122.567 1.00 112.19 ? 836 LEU A N   1 
ATOM   5204 C CA  . LEU A 1 855 ? -7.575  57.757  123.982 1.00 111.73 ? 836 LEU A CA  1 
ATOM   5205 C C   . LEU A 1 855 ? -8.244  56.384  124.218 1.00 100.18 ? 836 LEU A C   1 
ATOM   5206 O O   . LEU A 1 855 ? -7.935  55.664  125.184 1.00 85.12  ? 836 LEU A O   1 
ATOM   5207 C CB  . LEU A 1 855 ? -8.287  58.800  124.849 1.00 123.42 ? 836 LEU A CB  1 
ATOM   5208 C CG  . LEU A 1 855 ? -7.504  60.041  125.284 1.00 123.33 ? 836 LEU A CG  1 
ATOM   5209 C CD1 . LEU A 1 855 ? -7.380  61.019  124.096 1.00 114.01 ? 836 LEU A CD1 1 
ATOM   5210 C CD2 . LEU A 1 855 ? -8.134  60.681  126.549 1.00 107.52 ? 836 LEU A CD2 1 
ATOM   5211 N N   . ARG B 2 12  ? 12.002  31.573  90.046  1.00 140.39 ? 308 ARG B N   1 
ATOM   5212 C CA  . ARG B 2 12  ? 13.353  31.013  89.910  1.00 143.53 ? 308 ARG B CA  1 
ATOM   5213 C C   . ARG B 2 12  ? 13.930  31.064  88.494  1.00 137.60 ? 308 ARG B C   1 
ATOM   5214 O O   . ARG B 2 12  ? 15.132  31.267  88.337  1.00 137.00 ? 308 ARG B O   1 
ATOM   5215 C CB  . ARG B 2 12  ? 13.405  29.541  90.393  1.00 145.94 ? 308 ARG B CB  1 
ATOM   5216 C CG  . ARG B 2 12  ? 13.354  29.283  91.909  1.00 142.43 ? 308 ARG B CG  1 
ATOM   5217 C CD  . ARG B 2 12  ? 14.613  29.862  92.564  1.00 148.08 ? 308 ARG B CD  1 
ATOM   5218 N NE  . ARG B 2 12  ? 14.428  31.247  93.013  1.00 149.85 ? 308 ARG B NE  1 
ATOM   5219 C CZ  . ARG B 2 12  ? 15.419  32.106  93.259  1.00 145.41 ? 308 ARG B CZ  1 
ATOM   5220 N NH1 . ARG B 2 12  ? 16.682  31.758  93.029  1.00 144.20 ? 308 ARG B NH1 1 
ATOM   5221 N NH2 . ARG B 2 12  ? 15.138  33.337  93.691  1.00 134.94 ? 308 ARG B NH2 1 
ATOM   5222 N N   . LYS B 2 13  ? 13.101  30.862  87.475  1.00 133.76 ? 309 LYS B N   1 
ATOM   5223 C CA  . LYS B 2 13  ? 13.617  30.622  86.135  1.00 130.07 ? 309 LYS B CA  1 
ATOM   5224 C C   . LYS B 2 13  ? 12.727  31.304  85.094  1.00 125.03 ? 309 LYS B C   1 
ATOM   5225 O O   . LYS B 2 13  ? 11.548  31.544  85.350  1.00 125.01 ? 309 LYS B O   1 
ATOM   5226 C CB  . LYS B 2 13  ? 13.730  29.116  85.856  1.00 134.78 ? 309 LYS B CB  1 
ATOM   5227 C CG  . LYS B 2 13  ? 15.000  28.463  86.435  1.00 142.94 ? 309 LYS B CG  1 
ATOM   5228 C CD  . LYS B 2 13  ? 15.026  26.942  86.188  1.00 150.05 ? 309 LYS B CD  1 
ATOM   5229 C CE  . LYS B 2 13  ? 15.762  26.558  84.897  1.00 143.41 ? 309 LYS B CE  1 
ATOM   5230 N NZ  . LYS B 2 13  ? 16.097  25.100  84.832  1.00 129.27 ? 309 LYS B NZ  1 
ATOM   5231 N N   . PRO B 2 14  ? 13.284  31.616  83.919  1.00 121.08 ? 310 PRO B N   1 
ATOM   5232 C CA  . PRO B 2 14  ? 12.577  32.480  82.954  1.00 115.32 ? 310 PRO B CA  1 
ATOM   5233 C C   . PRO B 2 14  ? 11.370  31.780  82.363  1.00 115.32 ? 310 PRO B C   1 
ATOM   5234 O O   . PRO B 2 14  ? 11.159  30.590  82.628  1.00 119.15 ? 310 PRO B O   1 
ATOM   5235 C CB  . PRO B 2 14  ? 13.648  32.732  81.879  1.00 109.50 ? 310 PRO B CB  1 
ATOM   5236 C CG  . PRO B 2 14  ? 14.525  31.579  81.953  1.00 108.08 ? 310 PRO B CG  1 
ATOM   5237 C CD  . PRO B 2 14  ? 14.600  31.204  83.399  1.00 115.78 ? 310 PRO B CD  1 
ATOM   5238 N N   . PRO B 2 15  ? 10.549  32.467  81.564  1.00 111.04 ? 311 PRO B N   1 
ATOM   5239 C CA  . PRO B 2 15  ? 9.511   31.750  80.824  1.00 112.84 ? 311 PRO B CA  1 
ATOM   5240 C C   . PRO B 2 15  ? 10.190  30.806  79.862  1.00 116.89 ? 311 PRO B C   1 
ATOM   5241 O O   . PRO B 2 15  ? 11.364  30.971  79.526  1.00 119.97 ? 311 PRO B O   1 
ATOM   5242 C CB  . PRO B 2 15  ? 8.731   32.841  80.080  1.00 108.91 ? 311 PRO B CB  1 
ATOM   5243 C CG  . PRO B 2 15  ? 9.559   34.017  80.100  1.00 105.53 ? 311 PRO B CG  1 
ATOM   5244 C CD  . PRO B 2 15  ? 10.626  33.880  81.160  1.00 109.11 ? 311 PRO B CD  1 
ATOM   5245 N N   . LYS B 2 16  ? 9.449   29.785  79.447  1.00 122.33 ? 312 LYS B N   1 
ATOM   5246 C CA  . LYS B 2 16  ? 10.040  28.759  78.606  1.00 129.36 ? 312 LYS B CA  1 
ATOM   5247 C C   . LYS B 2 16  ? 10.197  29.272  77.175  1.00 126.82 ? 312 LYS B C   1 
ATOM   5248 O O   . LYS B 2 16  ? 9.391   30.070  76.689  1.00 120.93 ? 312 LYS B O   1 
ATOM   5249 C CB  . LYS B 2 16  ? 9.196   27.483  78.656  1.00 127.38 ? 312 LYS B CB  1 
ATOM   5250 C CG  . LYS B 2 16  ? 7.755   27.673  78.224  1.00 130.52 ? 312 LYS B CG  1 
ATOM   5251 C CD  . LYS B 2 16  ? 7.090   26.330  77.951  1.00 131.63 ? 312 LYS B CD  1 
ATOM   5252 C CE  . LYS B 2 16  ? 7.729   25.656  76.731  1.00 131.95 ? 312 LYS B CE  1 
ATOM   5253 N NZ  . LYS B 2 16  ? 7.668   26.507  75.486  1.00 126.85 ? 312 LYS B NZ  1 
ATOM   5254 N N   . GLY B 2 17  ? 11.273  28.829  76.512  1.00 123.76 ? 313 GLY B N   1 
ATOM   5255 C CA  . GLY B 2 17  ? 11.652  29.305  75.185  1.00 124.76 ? 313 GLY B CA  1 
ATOM   5256 C C   . GLY B 2 17  ? 12.493  30.566  75.200  1.00 124.02 ? 313 GLY B C   1 
ATOM   5257 O O   . GLY B 2 17  ? 13.314  30.781  74.290  1.00 121.43 ? 313 GLY B O   1 
ATOM   5258 N N   . MET B 2 18  ? 12.285  31.407  76.208  1.00 113.05 ? 314 MET B N   1 
ATOM   5259 C CA  . MET B 2 18  ? 13.164  32.530  76.482  1.00 105.16 ? 314 MET B CA  1 
ATOM   5260 C C   . MET B 2 18  ? 14.506  32.026  76.985  1.00 107.45 ? 314 MET B C   1 
ATOM   5261 O O   . MET B 2 18  ? 14.565  31.149  77.849  1.00 108.60 ? 314 MET B O   1 
ATOM   5262 C CB  . MET B 2 18  ? 12.495  33.405  77.540  1.00 111.67 ? 314 MET B CB  1 
ATOM   5263 C CG  . MET B 2 18  ? 11.150  33.951  77.089  1.00 108.34 ? 314 MET B CG  1 
ATOM   5264 S SD  . MET B 2 18  ? 11.226  35.214  75.816  1.00 107.14 ? 314 MET B SD  1 
ATOM   5265 C CE  . MET B 2 18  ? 9.526   35.268  75.257  1.00 101.15 ? 314 MET B CE  1 
ATOM   5266 N N   . PHE B 2 19  ? 15.583  32.562  76.435  1.00 104.04 ? 315 PHE B N   1 
ATOM   5267 C CA  . PHE B 2 19  ? 16.901  32.008  76.712  1.00 115.50 ? 315 PHE B CA  1 
ATOM   5268 C C   . PHE B 2 19  ? 17.772  33.108  77.304  1.00 111.15 ? 315 PHE B C   1 
ATOM   5269 O O   . PHE B 2 19  ? 18.456  33.833  76.580  1.00 114.54 ? 315 PHE B O   1 
ATOM   5270 C CB  . PHE B 2 19  ? 17.517  31.413  75.442  1.00 114.26 ? 315 PHE B CB  1 
ATOM   5271 C CG  . PHE B 2 19  ? 17.204  29.957  75.238  1.00 116.30 ? 315 PHE B CG  1 
ATOM   5272 C CD1 . PHE B 2 19  ? 15.926  29.558  74.882  1.00 110.80 ? 315 PHE B CD1 1 
ATOM   5273 C CD2 . PHE B 2 19  ? 18.193  28.984  75.415  1.00 122.04 ? 315 PHE B CD2 1 
ATOM   5274 C CE1 . PHE B 2 19  ? 15.625  28.221  74.693  1.00 110.70 ? 315 PHE B CE1 1 
ATOM   5275 C CE2 . PHE B 2 19  ? 17.902  27.628  75.223  1.00 123.72 ? 315 PHE B CE2 1 
ATOM   5276 C CZ  . PHE B 2 19  ? 16.614  27.250  74.864  1.00 117.73 ? 315 PHE B CZ  1 
ATOM   5277 N N   . LEU B 2 20  ? 17.506  33.409  78.559  1.00 108.09 ? 316 LEU B N   1 
ATOM   5278 C CA  . LEU B 2 20  ? 18.200  34.558  79.161  1.00 109.12 ? 316 LEU B CA  1 
ATOM   5279 C C   . LEU B 2 20  ? 19.298  34.049  80.066  1.00 115.75 ? 316 LEU B C   1 
ATOM   5280 O O   . LEU B 2 20  ? 19.045  33.805  81.232  1.00 117.29 ? 316 LEU B O   1 
ATOM   5281 C CB  . LEU B 2 20  ? 17.172  35.366  79.937  1.00 104.57 ? 316 LEU B CB  1 
ATOM   5282 C CG  . LEU B 2 20  ? 15.864  35.554  79.186  1.00 103.88 ? 316 LEU B CG  1 
ATOM   5283 C CD1 . LEU B 2 20  ? 14.985  36.547  79.895  1.00 91.24  ? 316 LEU B CD1 1 
ATOM   5284 C CD2 . LEU B 2 20  ? 16.135  36.030  77.780  1.00 112.10 ? 316 LEU B CD2 1 
ATOM   5285 N N   . SER B 2 21  ? 20.486  33.904  79.509  1.00 118.31 ? 317 SER B N   1 
ATOM   5286 C CA  . SER B 2 21  ? 21.594  33.440  80.360  1.00 128.06 ? 317 SER B CA  1 
ATOM   5287 C C   . SER B 2 21  ? 22.029  34.625  81.194  1.00 126.16 ? 317 SER B C   1 
ATOM   5288 O O   . SER B 2 21  ? 21.942  35.746  80.711  1.00 120.19 ? 317 SER B O   1 
ATOM   5289 C CB  . SER B 2 21  ? 22.742  32.926  79.526  1.00 135.08 ? 317 SER B CB  1 
ATOM   5290 O OG  . SER B 2 21  ? 23.859  32.507  80.313  1.00 137.48 ? 317 SER B OG  1 
ATOM   5291 N N   . GLN B 2 22  ? 22.599  34.343  82.352  1.00 127.15 ? 318 GLN B N   1 
ATOM   5292 C CA  . GLN B 2 22  ? 23.159  35.468  83.114  1.00 132.13 ? 318 GLN B CA  1 
ATOM   5293 C C   . GLN B 2 22  ? 24.295  36.012  82.263  1.00 132.30 ? 318 GLN B C   1 
ATOM   5294 O O   . GLN B 2 22  ? 24.278  37.170  82.005  1.00 129.69 ? 318 GLN B O   1 
ATOM   5295 C CB  . GLN B 2 22  ? 23.730  35.009  84.449  1.00 136.63 ? 318 GLN B CB  1 
ATOM   5296 C CG  . GLN B 2 22  ? 24.799  35.953  84.974  1.00 140.56 ? 318 GLN B CG  1 
ATOM   5297 C CD  . GLN B 2 22  ? 24.237  37.289  85.385  1.00 143.04 ? 318 GLN B CD  1 
ATOM   5298 O OE1 . GLN B 2 22  ? 23.532  37.409  86.381  1.00 138.63 ? 318 GLN B OE1 1 
ATOM   5299 N NE2 . GLN B 2 22  ? 24.565  38.316  84.624  1.00 138.92 ? 318 GLN B NE2 1 
ATOM   5300 N N   . GLU B 2 23  ? 25.159  35.144  81.745  1.00 134.12 ? 319 GLU B N   1 
ATOM   5301 C CA  . GLU B 2 23  ? 26.343  35.545  80.950  1.00 135.87 ? 319 GLU B CA  1 
ATOM   5302 C C   . GLU B 2 23  ? 25.998  36.172  79.597  1.00 132.14 ? 319 GLU B C   1 
ATOM   5303 O O   . GLU B 2 23  ? 26.876  36.798  79.025  1.00 130.70 ? 319 GLU B O   1 
ATOM   5304 C CB  . GLU B 2 23  ? 27.203  34.311  80.697  1.00 140.11 ? 319 GLU B CB  1 
ATOM   5305 C CG  . GLU B 2 23  ? 28.197  34.505  79.572  1.00 144.49 ? 319 GLU B CG  1 
ATOM   5306 C CD  . GLU B 2 23  ? 28.634  33.240  78.859  1.00 152.65 ? 319 GLU B CD  1 
ATOM   5307 O OE1 . GLU B 2 23  ? 28.864  33.308  77.637  1.00 154.84 ? 319 GLU B OE1 1 
ATOM   5308 O OE2 . GLU B 2 23  ? 28.749  32.197  79.528  1.00 147.09 ? 319 GLU B OE2 1 
ATOM   5309 N N   . ASP B 2 24  ? 24.814  35.948  79.053  1.00 128.06 ? 320 ASP B N   1 
ATOM   5310 C CA  . ASP B 2 24  ? 24.612  36.491  77.687  1.00 123.37 ? 320 ASP B CA  1 
ATOM   5311 C C   . ASP B 2 24  ? 24.278  37.970  77.744  1.00 123.52 ? 320 ASP B C   1 
ATOM   5312 O O   . ASP B 2 24  ? 24.801  38.723  76.937  1.00 118.90 ? 320 ASP B O   1 
ATOM   5313 C CB  . ASP B 2 24  ? 23.452  35.811  76.976  1.00 125.12 ? 320 ASP B CB  1 
ATOM   5314 C CG  . ASP B 2 24  ? 23.612  34.313  76.892  1.00 127.42 ? 320 ASP B CG  1 
ATOM   5315 O OD1 . ASP B 2 24  ? 23.082  33.632  77.770  1.00 133.20 ? 320 ASP B OD1 1 
ATOM   5316 O OD2 . ASP B 2 24  ? 24.264  33.852  75.951  1.00 129.12 ? 320 ASP B OD2 1 
ATOM   5317 N N   . VAL B 2 25  ? 23.522  38.362  78.755  1.00 129.30 ? 321 VAL B N   1 
ATOM   5318 C CA  . VAL B 2 25  ? 23.010  39.754  78.866  1.00 124.81 ? 321 VAL B CA  1 
ATOM   5319 C C   . VAL B 2 25  ? 24.178  40.727  78.898  1.00 121.91 ? 321 VAL B C   1 
ATOM   5320 O O   . VAL B 2 25  ? 24.179  41.665  78.109  1.00 118.42 ? 321 VAL B O   1 
ATOM   5321 C CB  . VAL B 2 25  ? 22.164  39.902  80.138  1.00 116.86 ? 321 VAL B CB  1 
ATOM   5322 C CG1 . VAL B 2 25  ? 20.720  40.164  79.794  1.00 113.26 ? 321 VAL B CG1 1 
ATOM   5323 C CG2 . VAL B 2 25  ? 22.267  38.683  81.033  1.00 118.48 ? 321 VAL B CG2 1 
ATOM   5324 N N   . GLU B 2 26  ? 25.212  40.397  79.669  1.00 119.22 ? 322 GLU B N   1 
ATOM   5325 C CA  . GLU B 2 26  ? 26.380  41.295  79.779  1.00 123.66 ? 322 GLU B CA  1 
ATOM   5326 C C   . GLU B 2 26  ? 26.987  41.464  78.395  1.00 128.35 ? 322 GLU B C   1 
ATOM   5327 O O   . GLU B 2 26  ? 27.181  42.603  77.980  1.00 128.80 ? 322 GLU B O   1 
ATOM   5328 C CB  . GLU B 2 26  ? 27.456  40.664  80.654  1.00 123.79 ? 322 GLU B CB  1 
ATOM   5329 C CG  . GLU B 2 26  ? 27.017  40.403  82.075  1.00 124.05 ? 322 GLU B CG  1 
ATOM   5330 C CD  . GLU B 2 26  ? 26.079  39.222  82.182  1.00 136.06 ? 322 GLU B CD  1 
ATOM   5331 O OE1 . GLU B 2 26  ? 25.469  38.897  81.176  1.00 137.71 ? 322 GLU B OE1 1 
ATOM   5332 O OE2 . GLU B 2 26  ? 25.966  38.639  83.268  1.00 137.02 ? 322 GLU B OE2 1 
ATOM   5333 N N   . ALA B 2 27  ? 27.114  40.368  77.656  1.00 128.80 ? 323 ALA B N   1 
ATOM   5334 C CA  . ALA B 2 27  ? 27.712  40.415  76.311  1.00 129.97 ? 323 ALA B CA  1 
ATOM   5335 C C   . ALA B 2 27  ? 26.896  41.340  75.418  1.00 128.17 ? 323 ALA B C   1 
ATOM   5336 O O   . ALA B 2 27  ? 27.504  42.062  74.650  1.00 132.60 ? 323 ALA B O   1 
ATOM   5337 C CB  . ALA B 2 27  ? 27.773  39.026  75.744  1.00 129.16 ? 323 ALA B CB  1 
ATOM   5338 N N   . VAL B 2 28  ? 25.572  41.320  75.495  1.00 122.97 ? 324 VAL B N   1 
ATOM   5339 C CA  . VAL B 2 28  ? 24.827  42.262  74.618  1.00 126.53 ? 324 VAL B CA  1 
ATOM   5340 C C   . VAL B 2 28  ? 24.695  43.616  75.315  1.00 125.92 ? 324 VAL B C   1 
ATOM   5341 O O   . VAL B 2 28  ? 24.273  44.567  74.664  1.00 122.54 ? 324 VAL B O   1 
ATOM   5342 C CB  . VAL B 2 28  ? 23.472  41.676  74.208  1.00 122.90 ? 324 VAL B CB  1 
ATOM   5343 C CG1 . VAL B 2 28  ? 22.947  40.752  75.280  1.00 122.51 ? 324 VAL B CG1 1 
ATOM   5344 C CG2 . VAL B 2 28  ? 22.457  42.748  73.876  1.00 115.99 ? 324 VAL B CG2 1 
ATOM   5345 N N   . SER B 2 29  ? 25.029  43.702  76.598  1.00 126.04 ? 325 SER B N   1 
ATOM   5346 C CA  . SER B 2 29  ? 24.936  45.014  77.282  1.00 126.53 ? 325 SER B CA  1 
ATOM   5347 C C   . SER B 2 29  ? 26.305  45.690  77.358  1.00 130.68 ? 325 SER B C   1 
ATOM   5348 O O   . SER B 2 29  ? 26.355  46.870  77.687  1.00 129.61 ? 325 SER B O   1 
ATOM   5349 C CB  . SER B 2 29  ? 24.431  44.817  78.657  1.00 122.45 ? 325 SER B CB  1 
ATOM   5350 O OG  . SER B 2 29  ? 25.487  44.369  79.484  1.00 121.61 ? 325 SER B OG  1 
ATOM   5351 N N   . ALA B 2 30  ? 27.362  45.006  76.948  1.00 131.33 ? 326 ALA B N   1 
ATOM   5352 C CA  . ALA B 2 30  ? 28.721  45.559  77.138  1.00 130.19 ? 326 ALA B CA  1 
ATOM   5353 C C   . ALA B 2 30  ? 28.902  46.901  76.434  1.00 129.90 ? 326 ALA B C   1 
ATOM   5354 O O   . ALA B 2 30  ? 29.625  47.726  76.966  1.00 131.31 ? 326 ALA B O   1 
ATOM   5355 C CB  . ALA B 2 30  ? 29.745  44.561  76.689  1.00 128.72 ? 326 ALA B CB  1 
ATOM   5356 N N   . ASN B 2 31  ? 28.331  47.098  75.257  1.00 124.63 ? 327 ASN B N   1 
ATOM   5357 C CA  . ASN B 2 31  ? 28.539  48.408  74.599  1.00 128.88 ? 327 ASN B CA  1 
ATOM   5358 C C   . ASN B 2 31  ? 27.292  48.788  73.808  1.00 127.41 ? 327 ASN B C   1 
ATOM   5359 O O   . ASN B 2 31  ? 26.402  47.962  73.683  1.00 125.13 ? 327 ASN B O   1 
ATOM   5360 C CB  . ASN B 2 31  ? 29.858  48.456  73.840  1.00 132.39 ? 327 ASN B CB  1 
ATOM   5361 C CG  . ASN B 2 31  ? 29.714  48.004  72.409  1.00 138.55 ? 327 ASN B CG  1 
ATOM   5362 O OD1 . ASN B 2 31  ? 28.918  48.558  71.665  1.00 137.58 ? 327 ASN B OD1 1 
ATOM   5363 N ND2 . ASN B 2 31  ? 30.467  46.994  72.021  1.00 140.00 ? 327 ASN B ND2 1 
ATOM   5364 N N   . ALA B 2 32  ? 27.233  50.012  73.311  1.00 125.23 ? 328 ALA B N   1 
ATOM   5365 C CA  . ALA B 2 32  ? 26.001  50.458  72.629  1.00 129.59 ? 328 ALA B CA  1 
ATOM   5366 C C   . ALA B 2 32  ? 25.695  49.592  71.413  1.00 133.76 ? 328 ALA B C   1 
ATOM   5367 O O   . ALA B 2 32  ? 24.534  49.231  71.240  1.00 134.20 ? 328 ALA B O   1 
ATOM   5368 C CB  . ALA B 2 32  ? 26.155  51.893  72.219  1.00 124.80 ? 328 ALA B CB  1 
ATOM   5369 N N   . THR B 2 33  ? 26.711  49.282  70.616  1.00 136.16 ? 329 THR B N   1 
ATOM   5370 C CA  . THR B 2 33  ? 26.557  48.483  69.373  1.00 135.57 ? 329 THR B CA  1 
ATOM   5371 C C   . THR B 2 33  ? 26.955  47.034  69.624  1.00 130.58 ? 329 THR B C   1 
ATOM   5372 O O   . THR B 2 33  ? 26.967  46.256  68.671  1.00 125.93 ? 329 THR B O   1 
ATOM   5373 C CB  . THR B 2 33  ? 27.440  49.013  68.243  1.00 131.11 ? 329 THR B CB  1 
ATOM   5374 O OG1 . THR B 2 33  ? 28.600  49.608  68.820  1.00 126.89 ? 329 THR B OG1 1 
ATOM   5375 C CG2 . THR B 2 33  ? 26.721  50.004  67.359  1.00 123.93 ? 329 THR B CG2 1 
ATOM   5376 N N   . ALA B 2 34  ? 27.190  46.667  70.880  1.00 132.67 ? 330 ALA B N   1 
ATOM   5377 C CA  . ALA B 2 34  ? 27.613  45.285  71.187  1.00 126.42 ? 330 ALA B CA  1 
ATOM   5378 C C   . ALA B 2 34  ? 26.531  44.312  70.741  1.00 124.24 ? 330 ALA B C   1 
ATOM   5379 O O   . ALA B 2 34  ? 26.883  43.264  70.245  1.00 121.59 ? 330 ALA B O   1 
ATOM   5380 C CB  . ALA B 2 34  ? 27.877  45.140  72.653  1.00 124.57 ? 330 ALA B CB  1 
ATOM   5381 N N   . ALA B 2 35  ? 25.269  44.647  70.963  1.00 126.14 ? 331 ALA B N   1 
ATOM   5382 C CA  . ALA B 2 35  ? 24.158  43.784  70.534  1.00 121.85 ? 331 ALA B CA  1 
ATOM   5383 C C   . ALA B 2 35  ? 24.295  43.486  69.050  1.00 119.04 ? 331 ALA B C   1 
ATOM   5384 O O   . ALA B 2 35  ? 24.470  42.328  68.693  1.00 117.15 ? 331 ALA B O   1 
ATOM   5385 C CB  . ALA B 2 35  ? 22.873  44.508  70.781  1.00 125.19 ? 331 ALA B CB  1 
ATOM   5386 N N   . THR B 2 36  ? 24.162  44.496  68.205  1.00 121.28 ? 332 THR B N   1 
ATOM   5387 C CA  . THR B 2 36  ? 24.260  44.147  66.794  1.00 122.60 ? 332 THR B CA  1 
ATOM   5388 C C   . THR B 2 36  ? 25.643  43.626  66.408  1.00 121.74 ? 332 THR B C   1 
ATOM   5389 O O   . THR B 2 36  ? 25.801  43.116  65.295  1.00 122.38 ? 332 THR B O   1 
ATOM   5390 C CB  . THR B 2 36  ? 23.880  45.348  65.921  1.00 119.09 ? 332 THR B CB  1 
ATOM   5391 O OG1 . THR B 2 36  ? 24.618  46.504  66.335  1.00 123.98 ? 332 THR B OG1 1 
ATOM   5392 C CG2 . THR B 2 36  ? 22.380  45.632  66.034  1.00 113.16 ? 332 THR B CG2 1 
ATOM   5393 N N   . THR B 2 37  ? 26.640  43.720  67.290  1.00 122.71 ? 333 THR B N   1 
ATOM   5394 C CA  . THR B 2 37  ? 27.910  43.043  67.051  1.00 118.98 ? 333 THR B CA  1 
ATOM   5395 C C   . THR B 2 37  ? 27.701  41.536  67.093  1.00 119.54 ? 333 THR B C   1 
ATOM   5396 O O   . THR B 2 37  ? 27.785  40.873  66.058  1.00 120.19 ? 333 THR B O   1 
ATOM   5397 C CB  . THR B 2 37  ? 28.967  43.467  68.077  1.00 120.95 ? 333 THR B CB  1 
ATOM   5398 O OG1 . THR B 2 37  ? 29.438  44.783  67.761  1.00 120.33 ? 333 THR B OG1 1 
ATOM   5399 C CG2 . THR B 2 37  ? 30.144  42.494  68.097  1.00 110.07 ? 333 THR B CG2 1 
ATOM   5400 N N   . VAL B 2 38  ? 27.397  40.995  68.279  1.00 120.94 ? 334 VAL B N   1 
ATOM   5401 C CA  . VAL B 2 38  ? 27.246  39.550  68.441  1.00 118.13 ? 334 VAL B CA  1 
ATOM   5402 C C   . VAL B 2 38  ? 26.211  38.993  67.471  1.00 113.71 ? 334 VAL B C   1 
ATOM   5403 O O   . VAL B 2 38  ? 26.382  37.895  66.932  1.00 113.07 ? 334 VAL B O   1 
ATOM   5404 C CB  . VAL B 2 38  ? 26.891  39.230  69.906  1.00 116.75 ? 334 VAL B CB  1 
ATOM   5405 C CG1 . VAL B 2 38  ? 26.262  37.838  70.033  1.00 111.67 ? 334 VAL B CG1 1 
ATOM   5406 C CG2 . VAL B 2 38  ? 28.132  39.361  70.785  1.00 115.52 ? 334 VAL B CG2 1 
ATOM   5407 N N   . LEU B 2 39  ? 25.148  39.748  67.201  1.00 113.42 ? 335 LEU B N   1 
ATOM   5408 C CA  . LEU B 2 39  ? 24.084  39.258  66.330  1.00 115.69 ? 335 LEU B CA  1 
ATOM   5409 C C   . LEU B 2 39  ? 24.544  39.049  64.890  1.00 117.98 ? 335 LEU B C   1 
ATOM   5410 O O   . LEU B 2 39  ? 23.989  38.193  64.193  1.00 122.21 ? 335 LEU B O   1 
ATOM   5411 C CB  . LEU B 2 39  ? 22.901  40.223  66.341  1.00 121.37 ? 335 LEU B CB  1 
ATOM   5412 C CG  . LEU B 2 39  ? 21.885  40.141  67.471  1.00 118.33 ? 335 LEU B CG  1 
ATOM   5413 C CD1 . LEU B 2 39  ? 20.687  41.016  67.106  1.00 111.93 ? 335 LEU B CD1 1 
ATOM   5414 C CD2 . LEU B 2 39  ? 21.477  38.692  67.736  1.00 105.42 ? 335 LEU B CD2 1 
ATOM   5415 N N   . ARG B 2 40  ? 25.512  39.832  64.409  1.00 119.41 ? 336 ARG B N   1 
ATOM   5416 C CA  . ARG B 2 40  ? 26.021  39.697  63.045  1.00 120.06 ? 336 ARG B CA  1 
ATOM   5417 C C   . ARG B 2 40  ? 27.297  38.872  62.973  1.00 118.60 ? 336 ARG B C   1 
ATOM   5418 O O   . ARG B 2 40  ? 27.566  38.259  61.941  1.00 120.60 ? 336 ARG B O   1 
ATOM   5419 C CB  . ARG B 2 40  ? 26.249  41.088  62.446  1.00 119.26 ? 336 ARG B CB  1 
ATOM   5420 C CG  . ARG B 2 40  ? 26.671  41.187  60.995  1.00 129.81 ? 336 ARG B CG  1 
ATOM   5421 C CD  . ARG B 2 40  ? 26.801  42.678  60.763  1.00 140.79 ? 336 ARG B CD  1 
ATOM   5422 N NE  . ARG B 2 40  ? 27.823  43.200  61.672  1.00 146.21 ? 336 ARG B NE  1 
ATOM   5423 C CZ  . ARG B 2 40  ? 29.117  43.315  61.376  1.00 148.05 ? 336 ARG B CZ  1 
ATOM   5424 N NH1 . ARG B 2 40  ? 29.547  43.040  60.146  1.00 142.34 ? 336 ARG B NH1 1 
ATOM   5425 N NH2 . ARG B 2 40  ? 29.976  43.763  62.293  1.00 143.30 ? 336 ARG B NH2 1 
ATOM   5426 N N   . GLN B 2 41  ? 28.066  38.842  64.063  1.00 118.49 ? 337 GLN B N   1 
ATOM   5427 C CA  . GLN B 2 41  ? 29.105  37.838  64.279  1.00 118.15 ? 337 GLN B CA  1 
ATOM   5428 C C   . GLN B 2 41  ? 28.587  36.417  64.079  1.00 118.19 ? 337 GLN B C   1 
ATOM   5429 O O   . GLN B 2 41  ? 29.343  35.514  63.699  1.00 117.89 ? 337 GLN B O   1 
ATOM   5430 C CB  . GLN B 2 41  ? 29.652  38.000  65.703  1.00 126.81 ? 337 GLN B CB  1 
ATOM   5431 C CG  . GLN B 2 41  ? 30.738  37.036  66.148  1.00 131.52 ? 337 GLN B CG  1 
ATOM   5432 C CD  . GLN B 2 41  ? 31.967  37.069  65.274  1.00 140.28 ? 337 GLN B CD  1 
ATOM   5433 O OE1 . GLN B 2 41  ? 32.363  38.129  64.783  1.00 143.29 ? 337 GLN B OE1 1 
ATOM   5434 N NE2 . GLN B 2 41  ? 32.606  35.913  65.105  1.00 143.13 ? 337 GLN B NE2 1 
ATOM   5435 N N   . LEU B 2 42  ? 27.314  36.184  64.367  1.00 116.28 ? 338 LEU B N   1 
ATOM   5436 C CA  . LEU B 2 42  ? 26.734  34.888  64.098  1.00 112.59 ? 338 LEU B CA  1 
ATOM   5437 C C   . LEU B 2 42  ? 26.046  34.838  62.744  1.00 112.16 ? 338 LEU B C   1 
ATOM   5438 O O   . LEU B 2 42  ? 25.909  33.753  62.175  1.00 115.76 ? 338 LEU B O   1 
ATOM   5439 C CB  . LEU B 2 42  ? 25.753  34.508  65.209  1.00 108.23 ? 338 LEU B CB  1 
ATOM   5440 C CG  . LEU B 2 42  ? 26.402  34.550  66.600  1.00 113.15 ? 338 LEU B CG  1 
ATOM   5441 C CD1 . LEU B 2 42  ? 25.453  34.049  67.680  1.00 101.12 ? 338 LEU B CD1 1 
ATOM   5442 C CD2 . LEU B 2 42  ? 27.746  33.818  66.644  1.00 115.03 ? 338 LEU B CD2 1 
ATOM   5443 N N   . ASP B 2 43  ? 25.657  35.999  62.258  1.00 107.56 ? 339 ASP B N   1 
ATOM   5444 C CA  . ASP B 2 43  ? 25.001  36.023  60.942  1.00 111.39 ? 339 ASP B CA  1 
ATOM   5445 C C   . ASP B 2 43  ? 26.062  35.595  59.944  1.00 113.50 ? 339 ASP B C   1 
ATOM   5446 O O   . ASP B 2 43  ? 25.738  34.883  59.014  1.00 113.08 ? 339 ASP B O   1 
ATOM   5447 C CB  . ASP B 2 43  ? 24.482  37.423  60.641  1.00 122.65 ? 339 ASP B CB  1 
ATOM   5448 C CG  . ASP B 2 43  ? 22.987  37.564  60.829  1.00 121.78 ? 339 ASP B CG  1 
ATOM   5449 O OD1 . ASP B 2 43  ? 22.483  37.081  61.846  1.00 118.44 ? 339 ASP B OD1 1 
ATOM   5450 O OD2 . ASP B 2 43  ? 22.350  38.155  59.953  1.00 127.01 ? 339 ASP B OD2 1 
ATOM   5451 N N   . MET B 2 44  ? 27.297  36.016  60.176  1.00 116.24 ? 340 MET B N   1 
ATOM   5452 C CA  . MET B 2 44  ? 28.400  35.680  59.248  1.00 113.29 ? 340 MET B CA  1 
ATOM   5453 C C   . MET B 2 44  ? 28.806  34.235  59.474  1.00 112.92 ? 340 MET B C   1 
ATOM   5454 O O   . MET B 2 44  ? 28.864  33.489  58.512  1.00 115.51 ? 340 MET B O   1 
ATOM   5455 C CB  . MET B 2 44  ? 29.602  36.576  59.506  1.00 110.38 ? 340 MET B CB  1 
ATOM   5456 C CG  . MET B 2 44  ? 29.214  38.015  59.514  1.00 118.76 ? 340 MET B CG  1 
ATOM   5457 S SD  . MET B 2 44  ? 30.428  38.986  58.647  1.00 142.66 ? 340 MET B SD  1 
ATOM   5458 C CE  . MET B 2 44  ? 31.575  39.324  59.976  1.00 127.72 ? 340 MET B CE  1 
ATOM   5459 N N   . GLU B 2 45  ? 28.946  33.828  60.729  1.00 108.38 ? 341 GLU B N   1 
ATOM   5460 C CA  . GLU B 2 45  ? 29.334  32.431  61.025  1.00 107.89 ? 341 GLU B CA  1 
ATOM   5461 C C   . GLU B 2 45  ? 28.323  31.467  60.418  1.00 108.45 ? 341 GLU B C   1 
ATOM   5462 O O   . GLU B 2 45  ? 28.734  30.440  59.950  1.00 111.44 ? 341 GLU B O   1 
ATOM   5463 C CB  . GLU B 2 45  ? 29.388  32.182  62.522  1.00 115.12 ? 341 GLU B CB  1 
ATOM   5464 C CG  . GLU B 2 45  ? 29.378  30.711  62.853  1.00 115.05 ? 341 GLU B CG  1 
ATOM   5465 C CD  . GLU B 2 45  ? 30.690  30.202  63.413  1.00 128.60 ? 341 GLU B CD  1 
ATOM   5466 O OE1 . GLU B 2 45  ? 31.594  31.020  63.628  1.00 129.24 ? 341 GLU B OE1 1 
ATOM   5467 O OE2 . GLU B 2 45  ? 30.806  28.990  63.625  1.00 129.11 ? 341 GLU B OE2 1 
ATOM   5468 N N   . LEU B 2 46  ? 27.035  31.768  60.474  1.00 108.92 ? 342 LEU B N   1 
ATOM   5469 C CA  . LEU B 2 46  ? 26.058  30.871  59.832  1.00 109.90 ? 342 LEU B CA  1 
ATOM   5470 C C   . LEU B 2 46  ? 26.407  30.744  58.358  1.00 111.93 ? 342 LEU B C   1 
ATOM   5471 O O   . LEU B 2 46  ? 26.454  29.627  57.880  1.00 115.01 ? 342 LEU B O   1 
ATOM   5472 C CB  . LEU B 2 46  ? 24.662  31.463  59.975  1.00 115.24 ? 342 LEU B CB  1 
ATOM   5473 C CG  . LEU B 2 46  ? 23.573  30.586  59.383  1.00 115.21 ? 342 LEU B CG  1 
ATOM   5474 C CD1 . LEU B 2 46  ? 23.152  29.528  60.376  1.00 105.66 ? 342 LEU B CD1 1 
ATOM   5475 C CD2 . LEU B 2 46  ? 22.386  31.420  58.961  1.00 121.80 ? 342 LEU B CD2 1 
ATOM   5476 N N   . VAL B 2 47  ? 26.653  31.858  57.676  1.00 110.99 ? 343 VAL B N   1 
ATOM   5477 C CA  . VAL B 2 47  ? 27.000  31.806  56.229  1.00 111.64 ? 343 VAL B CA  1 
ATOM   5478 C C   . VAL B 2 47  ? 28.176  30.861  56.021  1.00 109.81 ? 343 VAL B C   1 
ATOM   5479 O O   . VAL B 2 47  ? 28.063  29.997  55.175  1.00 109.50 ? 343 VAL B O   1 
ATOM   5480 C CB  . VAL B 2 47  ? 27.331  33.195  55.679  1.00 109.75 ? 343 VAL B CB  1 
ATOM   5481 C CG1 . VAL B 2 47  ? 28.282  33.092  54.510  1.00 119.42 ? 343 VAL B CG1 1 
ATOM   5482 C CG2 . VAL B 2 47  ? 26.074  33.919  55.253  1.00 102.39 ? 343 VAL B CG2 1 
ATOM   5483 N N   . SER B 2 48  ? 29.232  31.017  56.810  1.00 109.94 ? 344 SER B N   1 
ATOM   5484 C CA  . SER B 2 48  ? 30.429  30.157  56.710  1.00 113.06 ? 344 SER B CA  1 
ATOM   5485 C C   . SER B 2 48  ? 30.015  28.690  56.733  1.00 112.49 ? 344 SER B C   1 
ATOM   5486 O O   . SER B 2 48  ? 30.410  27.965  55.853  1.00 120.41 ? 344 SER B O   1 
ATOM   5487 C CB  . SER B 2 48  ? 31.405  30.491  57.796  1.00 113.56 ? 344 SER B CB  1 
ATOM   5488 O OG  . SER B 2 48  ? 31.643  29.390  58.655  1.00 118.19 ? 344 SER B OG  1 
ATOM   5489 N N   . VAL B 2 49  ? 29.208  28.282  57.696  1.00 106.53 ? 345 VAL B N   1 
ATOM   5490 C CA  . VAL B 2 49  ? 28.822  26.850  57.711  1.00 108.60 ? 345 VAL B CA  1 
ATOM   5491 C C   . VAL B 2 49  ? 28.040  26.529  56.446  1.00 109.10 ? 345 VAL B C   1 
ATOM   5492 O O   . VAL B 2 49  ? 28.304  25.498  55.859  1.00 113.94 ? 345 VAL B O   1 
ATOM   5493 C CB  . VAL B 2 49  ? 27.982  26.505  58.937  1.00 104.64 ? 345 VAL B CB  1 
ATOM   5494 C CG1 . VAL B 2 49  ? 27.032  25.384  58.601  1.00 106.88 ? 345 VAL B CG1 1 
ATOM   5495 C CG2 . VAL B 2 49  ? 28.865  26.109  60.094  1.00 111.52 ? 345 VAL B CG2 1 
ATOM   5496 N N   . LYS B 2 50  ? 27.120  27.396  56.051  1.00 104.53 ? 346 LYS B N   1 
ATOM   5497 C CA  . LYS B 2 50  ? 26.322  27.134  54.836  1.00 109.30 ? 346 LYS B CA  1 
ATOM   5498 C C   . LYS B 2 50  ? 27.274  26.927  53.667  1.00 115.46 ? 346 LYS B C   1 
ATOM   5499 O O   . LYS B 2 50  ? 27.133  25.921  53.002  1.00 114.44 ? 346 LYS B O   1 
ATOM   5500 C CB  . LYS B 2 50  ? 25.350  28.280  54.581  1.00 117.46 ? 346 LYS B CB  1 
ATOM   5501 C CG  . LYS B 2 50  ? 23.949  28.060  55.133  1.00 131.39 ? 346 LYS B CG  1 
ATOM   5502 C CD  . LYS B 2 50  ? 22.887  28.832  54.387  1.00 132.46 ? 346 LYS B CD  1 
ATOM   5503 C CE  . LYS B 2 50  ? 21.582  28.951  55.143  1.00 128.53 ? 346 LYS B CE  1 
ATOM   5504 N NZ  . LYS B 2 50  ? 20.513  29.513  54.286  1.00 122.75 ? 346 LYS B NZ  1 
ATOM   5505 N N   . ARG B 2 51  ? 28.237  27.829  53.492  1.00 117.60 ? 347 ARG B N   1 
ATOM   5506 C CA  . ARG B 2 51  ? 29.272  27.704  52.439  1.00 111.14 ? 347 ARG B CA  1 
ATOM   5507 C C   . ARG B 2 51  ? 29.893  26.321  52.570  1.00 114.64 ? 347 ARG B C   1 
ATOM   5508 O O   . ARG B 2 51  ? 29.830  25.548  51.626  1.00 119.33 ? 347 ARG B O   1 
ATOM   5509 C CB  . ARG B 2 51  ? 30.389  28.707  52.721  1.00 114.59 ? 347 ARG B CB  1 
ATOM   5510 C CG  . ARG B 2 51  ? 30.773  29.575  51.535  1.00 121.93 ? 347 ARG B CG  1 
ATOM   5511 C CD  . ARG B 2 51  ? 31.381  30.898  51.948  1.00 127.19 ? 347 ARG B CD  1 
ATOM   5512 N NE  . ARG B 2 51  ? 30.488  31.957  51.518  1.00 136.35 ? 347 ARG B NE  1 
ATOM   5513 C CZ  . ARG B 2 51  ? 30.017  32.073  50.289  1.00 134.25 ? 347 ARG B CZ  1 
ATOM   5514 N NH1 . ARG B 2 51  ? 30.380  31.212  49.358  1.00 136.41 ? 347 ARG B NH1 1 
ATOM   5515 N NH2 . ARG B 2 51  ? 29.194  33.058  49.987  1.00 127.85 ? 347 ARG B NH2 1 
ATOM   5516 N N   . GLN B 2 52  ? 30.374  25.996  53.762  1.00 111.13 ? 348 GLN B N   1 
ATOM   5517 C CA  . GLN B 2 52  ? 31.013  24.689  54.016  1.00 112.31 ? 348 GLN B CA  1 
ATOM   5518 C C   . GLN B 2 52  ? 30.061  23.550  53.669  1.00 113.98 ? 348 GLN B C   1 
ATOM   5519 O O   . GLN B 2 52  ? 30.507  22.582  53.086  1.00 111.03 ? 348 GLN B O   1 
ATOM   5520 C CB  . GLN B 2 52  ? 31.390  24.593  55.486  1.00 115.39 ? 348 GLN B CB  1 
ATOM   5521 C CG  . GLN B 2 52  ? 32.192  23.350  55.808  1.00 122.35 ? 348 GLN B CG  1 
ATOM   5522 C CD  . GLN B 2 52  ? 33.519  23.355  55.099  1.00 127.15 ? 348 GLN B CD  1 
ATOM   5523 O OE1 . GLN B 2 52  ? 34.365  22.499  55.321  1.00 128.11 ? 348 GLN B OE1 1 
ATOM   5524 N NE2 . GLN B 2 52  ? 33.710  24.333  54.236  1.00 126.08 ? 348 GLN B NE2 1 
ATOM   5525 N N   . ILE B 2 53  ? 28.791  23.660  54.024  1.00 115.51 ? 349 ILE B N   1 
ATOM   5526 C CA  . ILE B 2 53  ? 27.853  22.552  53.711  1.00 110.59 ? 349 ILE B CA  1 
ATOM   5527 C C   . ILE B 2 53  ? 27.831  22.332  52.204  1.00 107.13 ? 349 ILE B C   1 
ATOM   5528 O O   . ILE B 2 53  ? 27.919  21.202  51.821  1.00 113.32 ? 349 ILE B O   1 
ATOM   5529 C CB  . ILE B 2 53  ? 26.448  22.834  54.267  1.00 114.17 ? 349 ILE B CB  1 
ATOM   5530 C CG1 . ILE B 2 53  ? 26.253  22.236  55.657  1.00 106.38 ? 349 ILE B CG1 1 
ATOM   5531 C CG2 . ILE B 2 53  ? 25.383  22.329  53.321  1.00 116.95 ? 349 ILE B CG2 1 
ATOM   5532 C CD1 . ILE B 2 53  ? 27.534  21.920  56.374  1.00 106.30 ? 349 ILE B CD1 1 
ATOM   5533 N N   . GLN B 2 54  ? 27.763  23.383  51.397  1.00 107.36 ? 350 GLN B N   1 
ATOM   5534 C CA  . GLN B 2 54  ? 27.681  23.195  49.932  1.00 111.07 ? 350 GLN B CA  1 
ATOM   5535 C C   . GLN B 2 54  ? 28.892  22.407  49.466  1.00 112.35 ? 350 GLN B C   1 
ATOM   5536 O O   . GLN B 2 54  ? 28.727  21.433  48.755  1.00 107.30 ? 350 GLN B O   1 
ATOM   5537 C CB  . GLN B 2 54  ? 27.761  24.541  49.227  1.00 108.45 ? 350 GLN B CB  1 
ATOM   5538 C CG  . GLN B 2 54  ? 26.414  25.172  48.933  1.00 113.88 ? 350 GLN B CG  1 
ATOM   5539 C CD  . GLN B 2 54  ? 25.356  24.167  48.565  1.00 124.32 ? 350 GLN B CD  1 
ATOM   5540 O OE1 . GLN B 2 54  ? 24.852  24.148  47.450  1.00 132.68 ? 350 GLN B OE1 1 
ATOM   5541 N NE2 . GLN B 2 54  ? 24.988  23.338  49.520  1.00 120.11 ? 350 GLN B NE2 1 
ATOM   5542 N N   . ASN B 2 55  ? 30.062  22.841  49.899  1.00 114.53 ? 351 ASN B N   1 
ATOM   5543 C CA  . ASN B 2 55  ? 31.341  22.223  49.498  1.00 109.56 ? 351 ASN B CA  1 
ATOM   5544 C C   . ASN B 2 55  ? 31.297  20.721  49.710  1.00 109.71 ? 351 ASN B C   1 
ATOM   5545 O O   . ASN B 2 55  ? 31.385  19.987  48.740  1.00 112.72 ? 351 ASN B O   1 
ATOM   5546 C CB  . ASN B 2 55  ? 32.464  22.748  50.370  1.00 113.85 ? 351 ASN B CB  1 
ATOM   5547 C CG  . ASN B 2 55  ? 33.770  22.710  49.632  1.00 116.79 ? 351 ASN B CG  1 
ATOM   5548 O OD1 . ASN B 2 55  ? 33.836  23.135  48.489  1.00 113.24 ? 351 ASN B OD1 1 
ATOM   5549 N ND2 . ASN B 2 55  ? 34.792  22.181  50.271  1.00 116.95 ? 351 ASN B ND2 1 
ATOM   5550 N N   . ILE B 2 56  ? 31.215  20.290  50.956  1.00 109.27 ? 352 ILE B N   1 
ATOM   5551 C CA  . ILE B 2 56  ? 31.202  18.831  51.210  1.00 101.51 ? 352 ILE B CA  1 
ATOM   5552 C C   . ILE B 2 56  ? 30.021  18.217  50.478  1.00 102.15 ? 352 ILE B C   1 
ATOM   5553 O O   . ILE B 2 56  ? 30.130  17.091  50.064  1.00 105.48 ? 352 ILE B O   1 
ATOM   5554 C CB  . ILE B 2 56  ? 31.156  18.551  52.706  1.00 100.16 ? 352 ILE B CB  1 
ATOM   5555 C CG1 . ILE B 2 56  ? 32.552  18.673  53.306  1.00 107.54 ? 352 ILE B CG1 1 
ATOM   5556 C CG2 . ILE B 2 56  ? 30.561  17.189  52.945  1.00 98.83  ? 352 ILE B CG2 1 
ATOM   5557 C CD1 . ILE B 2 56  ? 32.636  18.221  54.731  1.00 111.67 ? 352 ILE B CD1 1 
ATOM   5558 N N   . LYS B 2 57  ? 28.919  18.933  50.344  1.00 106.30 ? 353 LYS B N   1 
ATOM   5559 C CA  . LYS B 2 57  ? 27.846  18.328  49.568  1.00 107.07 ? 353 LYS B CA  1 
ATOM   5560 C C   . LYS B 2 57  ? 28.311  18.084  48.139  1.00 106.70 ? 353 LYS B C   1 
ATOM   5561 O O   . LYS B 2 57  ? 27.908  17.091  47.524  1.00 106.12 ? 353 LYS B O   1 
ATOM   5562 C CB  . LYS B 2 57  ? 26.585  19.199  49.610  1.00 110.48 ? 353 LYS B CB  1 
ATOM   5563 C CG  . LYS B 2 57  ? 25.299  18.431  49.292  1.00 116.86 ? 353 LYS B CG  1 
ATOM   5564 C CD  . LYS B 2 57  ? 24.098  19.353  49.072  1.00 119.82 ? 353 LYS B CD  1 
ATOM   5565 C CE  . LYS B 2 57  ? 23.394  19.709  50.373  1.00 125.09 ? 353 LYS B CE  1 
ATOM   5566 N NZ  . LYS B 2 57  ? 22.054  20.303  50.083  1.00 127.13 ? 353 LYS B NZ  1 
ATOM   5567 N N   . GLN B 2 58  ? 29.224  18.911  47.656  1.00 110.28 ? 354 GLN B N   1 
ATOM   5568 C CA  . GLN B 2 58  ? 29.730  18.695  46.281  1.00 107.62 ? 354 GLN B CA  1 
ATOM   5569 C C   . GLN B 2 58  ? 30.733  17.553  46.324  1.00 105.26 ? 354 GLN B C   1 
ATOM   5570 O O   . GLN B 2 58  ? 30.536  16.576  45.620  1.00 103.71 ? 354 GLN B O   1 
ATOM   5571 C CB  . GLN B 2 58  ? 30.405  19.954  45.760  1.00 109.12 ? 354 GLN B CB  1 
ATOM   5572 C CG  . GLN B 2 58  ? 29.429  21.087  45.525  1.00 115.75 ? 354 GLN B CG  1 
ATOM   5573 C CD  . GLN B 2 58  ? 29.229  21.335  44.056  1.00 123.16 ? 354 GLN B CD  1 
ATOM   5574 O OE1 . GLN B 2 58  ? 29.615  20.531  43.217  1.00 122.03 ? 354 GLN B OE1 1 
ATOM   5575 N NE2 . GLN B 2 58  ? 28.614  22.459  43.738  1.00 124.60 ? 354 GLN B NE2 1 
ATOM   5576 N N   . THR B 2 59  ? 31.746  17.692  47.167  1.00 102.73 ? 355 THR B N   1 
ATOM   5577 C CA  . THR B 2 59  ? 32.797  16.668  47.340  1.00 103.07 ? 355 THR B CA  1 
ATOM   5578 C C   . THR B 2 59  ? 32.157  15.309  47.541  1.00 104.66 ? 355 THR B C   1 
ATOM   5579 O O   . THR B 2 59  ? 32.446  14.413  46.779  1.00 105.30 ? 355 THR B O   1 
ATOM   5580 C CB  . THR B 2 59  ? 33.593  16.954  48.602  1.00 101.34 ? 355 THR B CB  1 
ATOM   5581 O OG1 . THR B 2 59  ? 33.972  18.312  48.442  1.00 111.67 ? 355 THR B OG1 1 
ATOM   5582 C CG2 . THR B 2 59  ? 34.826  16.097  48.707  1.00 100.04 ? 355 THR B CG2 1 
ATOM   5583 N N   . ASN B 2 60  ? 31.234  15.196  48.483  1.00 104.17 ? 356 ASN B N   1 
ATOM   5584 C CA  . ASN B 2 60  ? 30.563  13.891  48.665  1.00 100.05 ? 356 ASN B CA  1 
ATOM   5585 C C   . ASN B 2 60  ? 29.814  13.535  47.378  1.00 101.99 ? 356 ASN B C   1 
ATOM   5586 O O   . ASN B 2 60  ? 29.874  12.398  46.993  1.00 108.36 ? 356 ASN B O   1 
ATOM   5587 C CB  . ASN B 2 60  ? 29.722  13.858  49.937  1.00 101.99 ? 356 ASN B CB  1 
ATOM   5588 C CG  . ASN B 2 60  ? 30.519  13.471  51.163  1.00 105.51 ? 356 ASN B CG  1 
ATOM   5589 O OD1 . ASN B 2 60  ? 31.736  13.576  51.188  1.00 102.10 ? 356 ASN B OD1 1 
ATOM   5590 N ND2 . ASN B 2 60  ? 29.843  13.013  52.193  1.00 106.44 ? 356 ASN B ND2 1 
ATOM   5591 N N   . SER B 2 61  ? 29.160  14.476  46.708  1.00 101.50 ? 357 SER B N   1 
ATOM   5592 C CA  . SER B 2 61  ? 28.444  14.100  45.465  1.00 100.53 ? 357 SER B CA  1 
ATOM   5593 C C   . SER B 2 61  ? 29.422  13.539  44.438  1.00 107.63 ? 357 SER B C   1 
ATOM   5594 O O   . SER B 2 61  ? 29.088  12.566  43.787  1.00 106.00 ? 357 SER B O   1 
ATOM   5595 C CB  . SER B 2 61  ? 27.697  15.246  44.899  1.00 96.28  ? 357 SER B CB  1 
ATOM   5596 O OG  . SER B 2 61  ? 27.392  14.989  43.549  1.00 96.05  ? 357 SER B OG  1 
ATOM   5597 N N   . ALA B 2 62  ? 30.583  14.157  44.291  1.00 109.92 ? 358 ALA B N   1 
ATOM   5598 C CA  . ALA B 2 62  ? 31.574  13.653  43.320  1.00 105.97 ? 358 ALA B CA  1 
ATOM   5599 C C   . ALA B 2 62  ? 31.920  12.206  43.655  1.00 107.56 ? 358 ALA B C   1 
ATOM   5600 O O   . ALA B 2 62  ? 31.771  11.362  42.792  1.00 111.40 ? 358 ALA B O   1 
ATOM   5601 C CB  . ALA B 2 62  ? 32.795  14.517  43.362  1.00 103.34 ? 358 ALA B CB  1 
ATOM   5602 N N   . LEU B 2 63  ? 32.282  11.917  44.901  1.00 105.24 ? 359 LEU B N   1 
ATOM   5603 C CA  . LEU B 2 63  ? 32.650  10.537  45.307  1.00 103.43 ? 359 LEU B CA  1 
ATOM   5604 C C   . LEU B 2 63  ? 31.532  9.562   44.968  1.00 107.27 ? 359 LEU B C   1 
ATOM   5605 O O   . LEU B 2 63  ? 31.844  8.487   44.512  1.00 106.68 ? 359 LEU B O   1 
ATOM   5606 C CB  . LEU B 2 63  ? 32.933  10.488  46.804  1.00 101.52 ? 359 LEU B CB  1 
ATOM   5607 C CG  . LEU B 2 63  ? 33.975  11.476  47.293  1.00 104.30 ? 359 LEU B CG  1 
ATOM   5608 C CD1 . LEU B 2 63  ? 34.941  10.800  48.238  1.00 99.90  ? 359 LEU B CD1 1 
ATOM   5609 C CD2 . LEU B 2 63  ? 34.711  12.075  46.120  1.00 113.87 ? 359 LEU B CD2 1 
ATOM   5610 N N   . LYS B 2 64  ? 30.277  9.926   45.207  1.00 112.71 ? 360 LYS B N   1 
ATOM   5611 C CA  . LYS B 2 64  ? 29.128  9.063   44.857  1.00 116.09 ? 360 LYS B CA  1 
ATOM   5612 C C   . LYS B 2 64  ? 29.253  8.626   43.400  1.00 113.03 ? 360 LYS B C   1 
ATOM   5613 O O   . LYS B 2 64  ? 29.149  7.437   43.155  1.00 114.23 ? 360 LYS B O   1 
ATOM   5614 C CB  . LYS B 2 64  ? 27.833  9.863   44.987  1.00 116.78 ? 360 LYS B CB  1 
ATOM   5615 C CG  . LYS B 2 64  ? 26.955  9.557   46.193  1.00 119.42 ? 360 LYS B CG  1 
ATOM   5616 C CD  . LYS B 2 64  ? 25.875  10.596  46.382  1.00 114.07 ? 360 LYS B CD  1 
ATOM   5617 C CE  . LYS B 2 64  ? 24.612  10.056  47.007  1.00 123.58 ? 360 LYS B CE  1 
ATOM   5618 N NZ  . LYS B 2 64  ? 23.422  10.383  46.185  1.00 125.74 ? 360 LYS B NZ  1 
ATOM   5619 N N   . GLU B 2 65  ? 29.481  9.558   42.480  1.00 110.38 ? 361 GLU B N   1 
ATOM   5620 C CA  . GLU B 2 65  ? 29.591  9.196   41.048  1.00 115.06 ? 361 GLU B CA  1 
ATOM   5621 C C   . GLU B 2 65  ? 30.638  8.100   40.844  1.00 117.10 ? 361 GLU B C   1 
ATOM   5622 O O   . GLU B 2 65  ? 30.330  7.129   40.160  1.00 120.17 ? 361 GLU B O   1 
ATOM   5623 C CB  . GLU B 2 65  ? 29.920  10.424  40.209  1.00 113.10 ? 361 GLU B CB  1 
ATOM   5624 C CG  . GLU B 2 65  ? 29.526  10.250  38.761  1.00 127.47 ? 361 GLU B CG  1 
ATOM   5625 C CD  . GLU B 2 65  ? 29.046  11.501  38.054  1.00 137.16 ? 361 GLU B CD  1 
ATOM   5626 O OE1 . GLU B 2 65  ? 29.429  12.598  38.480  1.00 136.55 ? 361 GLU B OE1 1 
ATOM   5627 O OE2 . GLU B 2 65  ? 28.299  11.368  37.069  1.00 138.97 ? 361 GLU B OE2 1 
ATOM   5628 N N   . LYS B 2 66  ? 31.812  8.245   41.441  1.00 112.36 ? 362 LYS B N   1 
ATOM   5629 C CA  . LYS B 2 66  ? 32.879  7.236   41.248  1.00 109.24 ? 362 LYS B CA  1 
ATOM   5630 C C   . LYS B 2 66  ? 32.378  5.848   41.629  1.00 116.05 ? 362 LYS B C   1 
ATOM   5631 O O   . LYS B 2 66  ? 32.689  4.905   40.932  1.00 124.93 ? 362 LYS B O   1 
ATOM   5632 C CB  . LYS B 2 66  ? 34.110  7.596   42.075  1.00 97.61  ? 362 LYS B CB  1 
ATOM   5633 C CG  . LYS B 2 66  ? 34.982  8.682   41.472  1.00 103.90 ? 362 LYS B CG  1 
ATOM   5634 C CD  . LYS B 2 66  ? 36.272  8.876   42.221  1.00 109.85 ? 362 LYS B CD  1 
ATOM   5635 C CE  . LYS B 2 66  ? 36.944  10.200  41.933  1.00 120.69 ? 362 LYS B CE  1 
ATOM   5636 N NZ  . LYS B 2 66  ? 38.183  10.377  42.727  1.00 125.07 ? 362 LYS B NZ  1 
ATOM   5637 N N   . LEU B 2 67  ? 31.601  5.737   42.687  1.00 110.42 ? 363 LEU B N   1 
ATOM   5638 C CA  . LEU B 2 67  ? 31.162  4.423   43.117  1.00 110.69 ? 363 LEU B CA  1 
ATOM   5639 C C   . LEU B 2 67  ? 30.063  3.857   42.236  1.00 119.13 ? 363 LEU B C   1 
ATOM   5640 O O   . LEU B 2 67  ? 29.418  2.867   42.609  1.00 122.47 ? 363 LEU B O   1 
ATOM   5641 C CB  . LEU B 2 67  ? 30.712  4.478   44.575  1.00 108.17 ? 363 LEU B CB  1 
ATOM   5642 C CG  . LEU B 2 67  ? 31.849  4.716   45.567  1.00 109.69 ? 363 LEU B CG  1 
ATOM   5643 C CD1 . LEU B 2 67  ? 31.303  5.155   46.901  1.00 111.94 ? 363 LEU B CD1 1 
ATOM   5644 C CD2 . LEU B 2 67  ? 32.629  3.461   45.777  1.00 110.80 ? 363 LEU B CD2 1 
ATOM   5645 N N   . ASP B 2 68  ? 29.838  4.440   41.067  1.00 120.15 ? 364 ASP B N   1 
ATOM   5646 C CA  . ASP B 2 68  ? 28.777  3.942   40.208  1.00 129.81 ? 364 ASP B CA  1 
ATOM   5647 C C   . ASP B 2 68  ? 29.110  2.562   39.659  1.00 134.22 ? 364 ASP B C   1 
ATOM   5648 O O   . ASP B 2 68  ? 30.233  2.293   39.219  1.00 135.44 ? 364 ASP B O   1 
ATOM   5649 C CB  . ASP B 2 68  ? 28.510  4.894   39.054  1.00 136.87 ? 364 ASP B CB  1 
ATOM   5650 C CG  . ASP B 2 68  ? 27.101  4.758   38.529  1.00 143.61 ? 364 ASP B CG  1 
ATOM   5651 O OD1 . ASP B 2 68  ? 26.157  4.854   39.348  1.00 139.87 ? 364 ASP B OD1 1 
ATOM   5652 O OD2 . ASP B 2 68  ? 26.939  4.507   37.313  1.00 146.19 ? 364 ASP B OD2 1 
ATOM   5653 N N   . GLY B 2 69  ? 28.088  1.720   39.745  1.00 134.22 ? 365 GLY B N   1 
ATOM   5654 C CA  . GLY B 2 69  ? 28.190  0.297   39.397  1.00 135.96 ? 365 GLY B CA  1 
ATOM   5655 C C   . GLY B 2 69  ? 28.338  -0.507  40.671  1.00 130.90 ? 365 GLY B C   1 
ATOM   5656 O O   . GLY B 2 69  ? 28.152  -1.722  40.632  1.00 129.39 ? 365 GLY B O   1 
ATOM   5657 N N   . GLY B 2 70  ? 28.634  0.164   41.781  1.00 124.97 ? 366 GLY B N   1 
ATOM   5658 C CA  . GLY B 2 70  ? 28.833  -0.571  43.034  1.00 123.56 ? 366 GLY B CA  1 
ATOM   5659 C C   . GLY B 2 70  ? 29.939  -1.571  42.825  1.00 120.18 ? 366 GLY B C   1 
ATOM   5660 O O   . GLY B 2 70  ? 30.992  -1.185  42.343  1.00 120.56 ? 366 GLY B O   1 
ATOM   5661 N N   . ILE B 2 71  ? 29.722  -2.817  43.207  1.00 116.42 ? 367 ILE B N   1 
ATOM   5662 C CA  . ILE B 2 71  ? 30.771  -3.838  42.964  1.00 122.67 ? 367 ILE B CA  1 
ATOM   5663 C C   . ILE B 2 71  ? 30.087  -5.072  42.392  1.00 123.55 ? 367 ILE B C   1 
ATOM   5664 O O   . ILE B 2 71  ? 30.663  -6.139  42.468  1.00 121.17 ? 367 ILE B O   1 
ATOM   5665 C CB  . ILE B 2 71  ? 31.507  -4.179  44.263  1.00 117.97 ? 367 ILE B CB  1 
ATOM   5666 C CG1 . ILE B 2 71  ? 30.561  -4.707  45.328  1.00 110.28 ? 367 ILE B CG1 1 
ATOM   5667 C CG2 . ILE B 2 71  ? 32.296  -3.001  44.780  1.00 109.89 ? 367 ILE B CG2 1 
ATOM   5668 C CD1 . ILE B 2 71  ? 31.266  -5.022  46.607  1.00 109.48 ? 367 ILE B CD1 1 
ATOM   5669 N N   . GLU B 2 72  ? 28.898  -4.903  41.827  1.00 124.47 ? 368 GLU B N   1 
ATOM   5670 C CA  . GLU B 2 72  ? 28.137  -6.051  41.290  1.00 121.86 ? 368 GLU B CA  1 
ATOM   5671 C C   . GLU B 2 72  ? 28.993  -6.808  40.282  1.00 120.53 ? 368 GLU B C   1 
ATOM   5672 O O   . GLU B 2 72  ? 29.158  -8.013  40.429  1.00 119.59 ? 368 GLU B O   1 
ATOM   5673 C CB  . GLU B 2 72  ? 26.813  -5.555  40.729  1.00 124.49 ? 368 GLU B CB  1 
ATOM   5674 C CG  . GLU B 2 72  ? 25.825  -5.304  41.841  1.00 131.09 ? 368 GLU B CG  1 
ATOM   5675 C CD  . GLU B 2 72  ? 26.253  -5.954  43.141  1.00 134.65 ? 368 GLU B CD  1 
ATOM   5676 O OE1 . GLU B 2 72  ? 25.637  -6.950  43.525  1.00 132.47 ? 368 GLU B OE1 1 
ATOM   5677 O OE2 . GLU B 2 72  ? 27.206  -5.469  43.758  1.00 136.23 ? 368 GLU B OE2 1 
ATOM   5678 N N   . PRO B 2 73  ? 29.641  -6.139  39.318  1.00 118.59 ? 369 PRO B N   1 
ATOM   5679 C CA  . PRO B 2 73  ? 30.487  -6.821  38.353  1.00 121.71 ? 369 PRO B CA  1 
ATOM   5680 C C   . PRO B 2 73  ? 31.660  -7.592  38.964  1.00 117.20 ? 369 PRO B C   1 
ATOM   5681 O O   . PRO B 2 73  ? 32.057  -8.553  38.396  1.00 117.76 ? 369 PRO B O   1 
ATOM   5682 C CB  . PRO B 2 73  ? 31.093  -5.658  37.578  1.00 122.45 ? 369 PRO B CB  1 
ATOM   5683 C CG  . PRO B 2 73  ? 30.031  -4.619  37.648  1.00 120.68 ? 369 PRO B CG  1 
ATOM   5684 C CD  . PRO B 2 73  ? 29.529  -4.720  39.067  1.00 116.94 ? 369 PRO B CD  1 
ATOM   5685 N N   . TYR B 2 74  ? 32.178  -7.133  40.096  1.00 111.01 ? 370 TYR B N   1 
ATOM   5686 C CA  . TYR B 2 74  ? 33.331  -7.765  40.764  1.00 106.28 ? 370 TYR B CA  1 
ATOM   5687 C C   . TYR B 2 74  ? 32.845  -8.710  41.858  1.00 107.52 ? 370 TYR B C   1 
ATOM   5688 O O   . TYR B 2 74  ? 33.601  -9.017  42.746  1.00 99.28  ? 370 TYR B O   1 
ATOM   5689 C CB  . TYR B 2 74  ? 34.182  -6.674  41.406  1.00 108.09 ? 370 TYR B CB  1 
ATOM   5690 C CG  . TYR B 2 74  ? 34.612  -5.549  40.501  1.00 111.50 ? 370 TYR B CG  1 
ATOM   5691 C CD1 . TYR B 2 74  ? 33.761  -4.995  39.573  1.00 117.49 ? 370 TYR B CD1 1 
ATOM   5692 C CD2 . TYR B 2 74  ? 35.875  -5.008  40.603  1.00 111.92 ? 370 TYR B CD2 1 
ATOM   5693 C CE1 . TYR B 2 74  ? 34.151  -3.959  38.751  1.00 115.87 ? 370 TYR B CE1 1 
ATOM   5694 C CE2 . TYR B 2 74  ? 36.288  -3.967  39.794  1.00 112.92 ? 370 TYR B CE2 1 
ATOM   5695 C CZ  . TYR B 2 74  ? 35.419  -3.439  38.864  1.00 113.09 ? 370 TYR B CZ  1 
ATOM   5696 O OH  . TYR B 2 74  ? 35.811  -2.417  38.062  1.00 109.34 ? 370 TYR B OH  1 
ATOM   5697 N N   . ARG B 2 75  ? 31.609  -9.172  41.784  1.00 113.75 ? 371 ARG B N   1 
ATOM   5698 C CA  . ARG B 2 75  ? 31.115  -10.068 42.851  1.00 118.36 ? 371 ARG B CA  1 
ATOM   5699 C C   . ARG B 2 75  ? 31.282  -11.516 42.420  1.00 122.02 ? 371 ARG B C   1 
ATOM   5700 O O   . ARG B 2 75  ? 31.200  -11.786 41.226  1.00 120.05 ? 371 ARG B O   1 
ATOM   5701 C CB  . ARG B 2 75  ? 29.631  -9.819  43.087  1.00 121.28 ? 371 ARG B CB  1 
ATOM   5702 C CG  . ARG B 2 75  ? 29.256  -9.797  44.556  1.00 123.03 ? 371 ARG B CG  1 
ATOM   5703 C CD  . ARG B 2 75  ? 28.929  -8.378  44.937  1.00 130.23 ? 371 ARG B CD  1 
ATOM   5704 N NE  . ARG B 2 75  ? 28.122  -8.415  46.134  1.00 133.72 ? 371 ARG B NE  1 
ATOM   5705 C CZ  . ARG B 2 75  ? 27.593  -7.351  46.698  1.00 138.96 ? 371 ARG B CZ  1 
ATOM   5706 N NH1 . ARG B 2 75  ? 26.856  -7.485  47.785  1.00 143.76 ? 371 ARG B NH1 1 
ATOM   5707 N NH2 . ARG B 2 75  ? 27.786  -6.164  46.158  1.00 134.81 ? 371 ARG B NH2 1 
ATOM   5708 N N   . LEU B 2 76  ? 31.447  -12.414 43.382  1.00 120.55 ? 372 LEU B N   1 
ATOM   5709 C CA  . LEU B 2 76  ? 31.647  -13.829 43.018  1.00 119.86 ? 372 LEU B CA  1 
ATOM   5710 C C   . LEU B 2 76  ? 30.536  -14.665 43.619  1.00 127.58 ? 372 LEU B C   1 
ATOM   5711 O O   . LEU B 2 76  ? 30.227  -14.471 44.781  1.00 128.45 ? 372 LEU B O   1 
ATOM   5712 C CB  . LEU B 2 76  ? 32.964  -14.289 43.626  1.00 117.22 ? 372 LEU B CB  1 
ATOM   5713 C CG  . LEU B 2 76  ? 34.206  -13.713 42.968  1.00 117.51 ? 372 LEU B CG  1 
ATOM   5714 C CD1 . LEU B 2 76  ? 35.442  -14.384 43.520  1.00 110.82 ? 372 LEU B CD1 1 
ATOM   5715 C CD2 . LEU B 2 76  ? 34.128  -13.885 41.467  1.00 110.19 ? 372 LEU B CD2 1 
ATOM   5716 N N   . PRO B 2 77  ? 30.001  -15.650 42.883  1.00 130.46 ? 373 PRO B N   1 
ATOM   5717 C CA  . PRO B 2 77  ? 28.972  -16.531 43.401  1.00 128.92 ? 373 PRO B CA  1 
ATOM   5718 C C   . PRO B 2 77  ? 29.504  -17.297 44.611  1.00 132.82 ? 373 PRO B C   1 
ATOM   5719 O O   . PRO B 2 77  ? 30.628  -17.706 44.598  1.00 130.80 ? 373 PRO B O   1 
ATOM   5720 C CB  . PRO B 2 77  ? 28.795  -17.531 42.264  1.00 124.19 ? 373 PRO B CB  1 
ATOM   5721 C CG  . PRO B 2 77  ? 30.070  -17.416 41.491  1.00 124.07 ? 373 PRO B CG  1 
ATOM   5722 C CD  . PRO B 2 77  ? 30.357  -15.938 41.513  1.00 122.34 ? 373 PRO B CD  1 
ATOM   5723 N N   . GLU B 2 78  ? 28.648  -17.519 45.601  1.00 137.12 ? 374 GLU B N   1 
ATOM   5724 C CA  . GLU B 2 78  ? 29.075  -18.208 46.841  1.00 144.30 ? 374 GLU B CA  1 
ATOM   5725 C C   . GLU B 2 78  ? 29.043  -19.721 46.670  1.00 148.36 ? 374 GLU B C   1 
ATOM   5726 O O   . GLU B 2 78  ? 28.071  -20.246 46.132  1.00 147.13 ? 374 GLU B O   1 
ATOM   5727 C CB  . GLU B 2 78  ? 28.208  -17.779 48.018  1.00 148.50 ? 374 GLU B CB  1 
ATOM   5728 C CG  . GLU B 2 78  ? 28.915  -16.764 48.887  1.00 153.21 ? 374 GLU B CG  1 
ATOM   5729 C CD  . GLU B 2 78  ? 30.357  -16.573 48.462  1.00 154.39 ? 374 GLU B CD  1 
ATOM   5730 O OE1 . GLU B 2 78  ? 31.250  -16.990 49.218  1.00 156.09 ? 374 GLU B OE1 1 
ATOM   5731 O OE2 . GLU B 2 78  ? 30.580  -16.031 47.365  1.00 147.22 ? 374 GLU B OE2 1 
ATOM   5732 N N   . VAL B 2 79  ? 30.090  -20.378 47.149  1.00 149.84 ? 375 VAL B N   1 
ATOM   5733 C CA  . VAL B 2 79  ? 30.181  -21.856 47.055  1.00 149.94 ? 375 VAL B CA  1 
ATOM   5734 C C   . VAL B 2 79  ? 29.430  -22.408 48.255  1.00 154.63 ? 375 VAL B C   1 
ATOM   5735 O O   . VAL B 2 79  ? 29.567  -21.838 49.334  1.00 152.25 ? 375 VAL B O   1 
ATOM   5736 C CB  . VAL B 2 79  ? 31.649  -22.291 47.108  1.00 149.16 ? 375 VAL B CB  1 
ATOM   5737 C CG1 . VAL B 2 79  ? 32.340  -21.677 48.310  1.00 148.35 ? 375 VAL B CG1 1 
ATOM   5738 C CG2 . VAL B 2 79  ? 31.778  -23.799 47.135  1.00 145.13 ? 375 VAL B CG2 1 
ATOM   5739 N N   . ILE B 2 80  ? 28.680  -23.480 48.046  1.00 156.31 ? 376 ILE B N   1 
ATOM   5740 C CA  . ILE B 2 80  ? 27.894  -24.123 49.097  1.00 155.21 ? 376 ILE B CA  1 
ATOM   5741 C C   . ILE B 2 80  ? 28.381  -25.560 49.213  1.00 155.89 ? 376 ILE B C   1 
ATOM   5742 O O   . ILE B 2 80  ? 27.719  -26.479 48.713  1.00 159.08 ? 376 ILE B O   1 
ATOM   5743 C CB  . ILE B 2 80  ? 26.381  -24.131 48.786  1.00 157.05 ? 376 ILE B CB  1 
ATOM   5744 C CG1 . ILE B 2 80  ? 25.837  -22.733 48.487  1.00 155.38 ? 376 ILE B CG1 1 
ATOM   5745 C CG2 . ILE B 2 80  ? 25.602  -24.718 49.963  1.00 155.83 ? 376 ILE B CG2 1 
ATOM   5746 C CD1 . ILE B 2 80  ? 25.836  -22.389 47.003  1.00 144.48 ? 376 ILE B CD1 1 
ATOM   5747 N N   . GLN B 2 81  ? 29.538  -25.791 49.828  1.00 157.24 ? 377 GLN B N   1 
ATOM   5748 C CA  . GLN B 2 81  ? 30.083  -27.144 49.869  1.00 159.26 ? 377 GLN B CA  1 
ATOM   5749 C C   . GLN B 2 81  ? 30.036  -27.688 51.293  1.00 154.70 ? 377 GLN B C   1 
ATOM   5750 O O   . GLN B 2 81  ? 30.451  -27.014 52.249  1.00 142.96 ? 377 GLN B O   1 
ATOM   5751 C CB  . GLN B 2 81  ? 31.494  -27.218 49.258  1.00 154.73 ? 377 GLN B CB  1 
ATOM   5752 C CG  . GLN B 2 81  ? 32.682  -26.742 50.083  1.00 147.80 ? 377 GLN B CG  1 
ATOM   5753 C CD  . GLN B 2 81  ? 34.015  -27.030 49.381  1.00 145.13 ? 377 GLN B CD  1 
ATOM   5754 O OE1 . GLN B 2 81  ? 34.250  -28.138 48.874  1.00 139.25 ? 377 GLN B OE1 1 
ATOM   5755 N NE2 . GLN B 2 81  ? 34.885  -26.024 49.336  1.00 141.81 ? 377 GLN B NE2 1 
ATOM   5756 N N   . LYS B 2 82  ? 29.488  -28.900 51.415  1.00 156.37 ? 378 LYS B N   1 
ATOM   5757 C CA  . LYS B 2 82  ? 29.219  -29.512 52.710  1.00 153.96 ? 378 LYS B CA  1 
ATOM   5758 C C   . LYS B 2 82  ? 30.528  -29.779 53.443  1.00 148.99 ? 378 LYS B C   1 
ATOM   5759 O O   . LYS B 2 82  ? 31.488  -30.292 52.857  1.00 153.01 ? 378 LYS B O   1 
ATOM   5760 C CB  . LYS B 2 82  ? 28.431  -30.818 52.519  1.00 150.37 ? 378 LYS B CB  1 
ATOM   5761 C CG  . LYS B 2 82  ? 27.040  -30.674 51.866  1.00 144.12 ? 378 LYS B CG  1 
ATOM   5762 C CD  . LYS B 2 82  ? 26.145  -31.879 52.191  1.00 145.34 ? 378 LYS B CD  1 
ATOM   5763 C CE  . LYS B 2 82  ? 24.774  -31.799 51.512  1.00 147.07 ? 378 LYS B CE  1 
ATOM   5764 N NZ  . LYS B 2 82  ? 23.914  -33.001 51.800  1.00 137.23 ? 378 LYS B NZ  1 
ATOM   5765 N N   . CYS B 2 83  ? 30.631  -29.267 54.660  1.00 140.92 ? 379 CYS B N   1 
ATOM   5766 C CA  . CYS B 2 83  ? 31.919  -29.434 55.359  1.00 141.41 ? 379 CYS B CA  1 
ATOM   5767 C C   . CYS B 2 83  ? 32.203  -30.915 55.560  1.00 142.51 ? 379 CYS B C   1 
ATOM   5768 O O   . CYS B 2 83  ? 31.308  -31.609 56.006  1.00 146.07 ? 379 CYS B O   1 
ATOM   5769 C CB  . CYS B 2 83  ? 31.894  -28.835 56.748  1.00 140.28 ? 379 CYS B CB  1 
ATOM   5770 S SG  . CYS B 2 83  ? 33.088  -29.692 57.796  1.00 139.59 ? 379 CYS B SG  1 
ATOM   5771 N N   . ASN B 2 84  ? 33.421  -31.345 55.243  1.00 144.69 ? 380 ASN B N   1 
ATOM   5772 C CA  . ASN B 2 84  ? 33.870  -32.751 55.434  1.00 144.16 ? 380 ASN B CA  1 
ATOM   5773 C C   . ASN B 2 84  ? 34.750  -32.811 56.689  1.00 139.77 ? 380 ASN B C   1 
ATOM   5774 O O   . ASN B 2 84  ? 34.933  -31.771 57.335  1.00 136.03 ? 380 ASN B O   1 
ATOM   5775 C CB  . ASN B 2 84  ? 34.579  -33.270 54.181  1.00 142.19 ? 380 ASN B CB  1 
ATOM   5776 C CG  . ASN B 2 84  ? 34.505  -34.772 54.020  1.00 145.51 ? 380 ASN B CG  1 
ATOM   5777 O OD1 . ASN B 2 84  ? 35.006  -35.499 54.875  1.00 141.74 ? 380 ASN B OD1 1 
ATOM   5778 N ND2 . ASN B 2 84  ? 33.880  -35.241 52.955  1.00 142.71 ? 380 ASN B ND2 1 
ATOM   5779 N N   . ALA B 2 85  ? 35.272  -33.981 57.045  1.00 136.77 ? 381 ALA B N   1 
ATOM   5780 C CA  . ALA B 2 85  ? 36.112  -34.062 58.254  1.00 133.62 ? 381 ALA B CA  1 
ATOM   5781 C C   . ALA B 2 85  ? 37.383  -34.839 57.938  1.00 135.15 ? 381 ALA B C   1 
ATOM   5782 O O   . ALA B 2 85  ? 38.259  -34.900 58.799  1.00 124.29 ? 381 ALA B O   1 
ATOM   5783 C CB  . ALA B 2 85  ? 35.336  -34.712 59.360  1.00 137.32 ? 381 ALA B CB  1 
ATOM   5784 N N   . ARG B 2 86  ? 37.452  -35.435 56.754  1.00 137.21 ? 382 ARG B N   1 
ATOM   5785 C CA  . ARG B 2 86  ? 38.680  -36.170 56.376  1.00 136.10 ? 382 ARG B CA  1 
ATOM   5786 C C   . ARG B 2 86  ? 39.622  -35.164 55.729  1.00 135.19 ? 382 ARG B C   1 
ATOM   5787 O O   . ARG B 2 86  ? 39.139  -34.288 55.020  1.00 135.86 ? 382 ARG B O   1 
ATOM   5788 C CB  . ARG B 2 86  ? 38.344  -37.291 55.393  1.00 133.93 ? 382 ARG B CB  1 
ATOM   5789 C CG  . ARG B 2 86  ? 39.554  -37.949 54.747  1.00 141.77 ? 382 ARG B CG  1 
ATOM   5790 C CD  . ARG B 2 86  ? 40.412  -38.723 55.726  1.00 154.30 ? 382 ARG B CD  1 
ATOM   5791 N NE  . ARG B 2 86  ? 40.279  -40.167 55.586  1.00 165.37 ? 382 ARG B NE  1 
ATOM   5792 C CZ  . ARG B 2 86  ? 40.837  -41.056 56.400  1.00 163.22 ? 382 ARG B CZ  1 
ATOM   5793 N NH1 . ARG B 2 86  ? 40.657  -42.350 56.198  1.00 156.75 ? 382 ARG B NH1 1 
ATOM   5794 N NH2 . ARG B 2 86  ? 41.579  -40.651 57.414  1.00 161.12 ? 382 ARG B NH2 1 
ATOM   5795 N N   . TRP B 2 87  ? 40.915  -35.276 55.992  1.00 132.90 ? 383 TRP B N   1 
ATOM   5796 C CA  . TRP B 2 87  ? 41.873  -34.329 55.380  1.00 125.72 ? 383 TRP B CA  1 
ATOM   5797 C C   . TRP B 2 87  ? 42.546  -34.985 54.186  1.00 126.81 ? 383 TRP B C   1 
ATOM   5798 O O   . TRP B 2 87  ? 43.447  -35.784 54.411  1.00 127.66 ? 383 TRP B O   1 
ATOM   5799 C CB  . TRP B 2 87  ? 42.930  -33.932 56.398  1.00 121.00 ? 383 TRP B CB  1 
ATOM   5800 C CG  . TRP B 2 87  ? 42.379  -32.967 57.385  1.00 124.32 ? 383 TRP B CG  1 
ATOM   5801 C CD1 . TRP B 2 87  ? 41.544  -33.255 58.411  1.00 129.49 ? 383 TRP B CD1 1 
ATOM   5802 C CD2 . TRP B 2 87  ? 42.575  -31.549 57.409  1.00 127.34 ? 383 TRP B CD2 1 
ATOM   5803 N NE1 . TRP B 2 87  ? 41.232  -32.116 59.092  1.00 133.99 ? 383 TRP B NE1 1 
ATOM   5804 C CE2 . TRP B 2 87  ? 41.844  -31.055 58.497  1.00 127.83 ? 383 TRP B CE2 1 
ATOM   5805 C CE3 . TRP B 2 87  ? 43.303  -30.652 56.636  1.00 124.12 ? 383 TRP B CE3 1 
ATOM   5806 C CZ2 . TRP B 2 87  ? 41.824  -29.708 58.829  1.00 128.61 ? 383 TRP B CZ2 1 
ATOM   5807 C CZ3 . TRP B 2 87  ? 43.283  -29.320 56.963  1.00 116.63 ? 383 TRP B CZ3 1 
ATOM   5808 C CH2 . TRP B 2 87  ? 42.552  -28.855 58.045  1.00 120.74 ? 383 TRP B CH2 1 
ATOM   5809 N N   . THR B 2 88  ? 42.203  -34.571 52.964  1.00 119.22 ? 384 THR B N   1 
ATOM   5810 C CA  . THR B 2 88  ? 42.868  -35.160 51.779  1.00 115.68 ? 384 THR B CA  1 
ATOM   5811 C C   . THR B 2 88  ? 44.265  -34.564 51.663  1.00 115.12 ? 384 THR B C   1 
ATOM   5812 O O   . THR B 2 88  ? 44.437  -33.435 52.158  1.00 109.92 ? 384 THR B O   1 
ATOM   5813 C CB  . THR B 2 88  ? 42.054  -34.914 50.513  1.00 118.33 ? 384 THR B CB  1 
ATOM   5814 O OG1 . THR B 2 88  ? 42.549  -33.755 49.854  1.00 120.82 ? 384 THR B OG1 1 
ATOM   5815 C CG2 . THR B 2 88  ? 40.592  -34.716 50.813  1.00 119.91 ? 384 THR B CG2 1 
ATOM   5816 N N   . THR B 2 89  ? 45.174  -35.260 50.969  1.00 112.00 ? 385 THR B N   1 
ATOM   5817 C CA  . THR B 2 89  ? 46.530  -34.735 50.891  1.00 105.45 ? 385 THR B CA  1 
ATOM   5818 C C   . THR B 2 89  ? 46.514  -33.313 50.334  1.00 102.75 ? 385 THR B C   1 
ATOM   5819 O O   . THR B 2 89  ? 47.242  -32.436 50.812  1.00 94.38  ? 385 THR B O   1 
ATOM   5820 C CB  . THR B 2 89  ? 47.395  -35.647 50.026  1.00 101.27 ? 385 THR B CB  1 
ATOM   5821 O OG1 . THR B 2 89  ? 47.135  -37.017 50.361  1.00 106.24 ? 385 THR B OG1 1 
ATOM   5822 C CG2 . THR B 2 89  ? 48.856  -35.341 50.263  1.00 89.86  ? 385 THR B CG2 1 
ATOM   5823 N N   . GLU B 2 90  ? 45.649  -33.063 49.349  1.00 105.79 ? 386 GLU B N   1 
ATOM   5824 C CA  . GLU B 2 90  ? 45.429  -31.715 48.836  1.00 105.36 ? 386 GLU B CA  1 
ATOM   5825 C C   . GLU B 2 90  ? 45.065  -30.741 49.956  1.00 103.67 ? 386 GLU B C   1 
ATOM   5826 O O   . GLU B 2 90  ? 45.731  -29.717 50.146  1.00 98.74  ? 386 GLU B O   1 
ATOM   5827 C CB  . GLU B 2 90  ? 44.330  -31.751 47.768  1.00 109.66 ? 386 GLU B CB  1 
ATOM   5828 C CG  . GLU B 2 90  ? 43.564  -30.429 47.606  1.00 113.98 ? 386 GLU B CG  1 
ATOM   5829 C CD  . GLU B 2 90  ? 42.343  -30.557 46.695  1.00 125.82 ? 386 GLU B CD  1 
ATOM   5830 O OE1 . GLU B 2 90  ? 41.966  -31.710 46.355  1.00 126.05 ? 386 GLU B OE1 1 
ATOM   5831 O OE2 . GLU B 2 90  ? 41.760  -29.503 46.331  1.00 125.98 ? 386 GLU B OE2 1 
ATOM   5832 N N   . GLU B 2 91  ? 44.018  -31.070 50.723  1.00 109.26 ? 387 GLU B N   1 
ATOM   5833 C CA  . GLU B 2 91  ? 43.465  -30.109 51.715  1.00 106.93 ? 387 GLU B CA  1 
ATOM   5834 C C   . GLU B 2 91  ? 44.546  -29.758 52.711  1.00 99.62  ? 387 GLU B C   1 
ATOM   5835 O O   . GLU B 2 91  ? 44.665  -28.597 53.040  1.00 95.42  ? 387 GLU B O   1 
ATOM   5836 C CB  . GLU B 2 91  ? 42.144  -30.575 52.325  1.00 109.31 ? 387 GLU B CB  1 
ATOM   5837 C CG  . GLU B 2 91  ? 41.253  -31.199 51.284  1.00 119.07 ? 387 GLU B CG  1 
ATOM   5838 C CD  . GLU B 2 91  ? 39.744  -31.131 51.251  1.00 127.66 ? 387 GLU B CD  1 
ATOM   5839 O OE1 . GLU B 2 91  ? 39.120  -32.073 51.733  1.00 129.89 ? 387 GLU B OE1 1 
ATOM   5840 O OE2 . GLU B 2 91  ? 39.209  -30.190 50.654  1.00 137.08 ? 387 GLU B OE2 1 
ATOM   5841 N N   . GLN B 2 92  ? 45.277  -30.761 53.148  1.00 98.04  ? 388 GLN B N   1 
ATOM   5842 C CA  . GLN B 2 92  ? 46.396  -30.487 54.040  1.00 97.10  ? 388 GLN B CA  1 
ATOM   5843 C C   . GLN B 2 92  ? 47.312  -29.439 53.435  1.00 94.24  ? 388 GLN B C   1 
ATOM   5844 O O   . GLN B 2 92  ? 47.802  -28.549 54.137  1.00 95.91  ? 388 GLN B O   1 
ATOM   5845 C CB  . GLN B 2 92  ? 47.175  -31.770 54.321  1.00 101.89 ? 388 GLN B CB  1 
ATOM   5846 C CG  . GLN B 2 92  ? 46.313  -32.966 54.688  1.00 108.89 ? 388 GLN B CG  1 
ATOM   5847 C CD  . GLN B 2 92  ? 47.138  -34.140 55.140  1.00 108.00 ? 388 GLN B CD  1 
ATOM   5848 O OE1 . GLN B 2 92  ? 48.354  -34.032 55.284  1.00 98.52  ? 388 GLN B OE1 1 
ATOM   5849 N NE2 . GLN B 2 92  ? 46.487  -35.283 55.335  1.00 116.71 ? 388 GLN B NE2 1 
ATOM   5850 N N   . LEU B 2 93  ? 47.530  -29.511 52.119  1.00 102.18 ? 389 LEU B N   1 
ATOM   5851 C CA  . LEU B 2 93  ? 48.502  -28.627 51.481  1.00 92.19  ? 389 LEU B CA  1 
ATOM   5852 C C   . LEU B 2 93  ? 47.963  -27.213 51.362  1.00 90.44  ? 389 LEU B C   1 
ATOM   5853 O O   . LEU B 2 93  ? 48.665  -26.248 51.686  1.00 90.50  ? 389 LEU B O   1 
ATOM   5854 C CB  . LEU B 2 93  ? 48.903  -29.172 50.118  1.00 81.21  ? 389 LEU B CB  1 
ATOM   5855 C CG  . LEU B 2 93  ? 50.100  -30.104 50.217  1.00 77.67  ? 389 LEU B CG  1 
ATOM   5856 C CD1 . LEU B 2 93  ? 50.196  -30.917 48.959  1.00 82.07  ? 389 LEU B CD1 1 
ATOM   5857 C CD2 . LEU B 2 93  ? 51.415  -29.391 50.539  1.00 71.38  ? 389 LEU B CD2 1 
ATOM   5858 N N   . LEU B 2 94  ? 46.716  -27.078 50.911  1.00 91.45  ? 390 LEU B N   1 
ATOM   5859 C CA  . LEU B 2 94  ? 46.018  -25.803 50.999  1.00 96.27  ? 390 LEU B CA  1 
ATOM   5860 C C   . LEU B 2 94  ? 46.241  -25.176 52.377  1.00 97.46  ? 390 LEU B C   1 
ATOM   5861 O O   . LEU B 2 94  ? 46.495  -23.972 52.496  1.00 93.74  ? 390 LEU B O   1 
ATOM   5862 C CB  . LEU B 2 94  ? 44.529  -26.003 50.731  1.00 92.48  ? 390 LEU B CB  1 
ATOM   5863 C CG  . LEU B 2 94  ? 44.175  -26.172 49.268  1.00 93.60  ? 390 LEU B CG  1 
ATOM   5864 C CD1 . LEU B 2 94  ? 42.700  -26.511 49.046  1.00 102.89 ? 390 LEU B CD1 1 
ATOM   5865 C CD2 . LEU B 2 94  ? 44.545  -24.896 48.580  1.00 95.49  ? 390 LEU B CD2 1 
ATOM   5866 N N   . ALA B 2 95  ? 46.194  -26.011 53.419  1.00 96.93  ? 391 ALA B N   1 
ATOM   5867 C CA  . ALA B 2 95  ? 46.257  -25.522 54.790  1.00 94.80  ? 391 ALA B CA  1 
ATOM   5868 C C   . ALA B 2 95  ? 47.601  -24.872 55.093  1.00 94.42  ? 391 ALA B C   1 
ATOM   5869 O O   . ALA B 2 95  ? 47.664  -23.684 55.433  1.00 93.71  ? 391 ALA B O   1 
ATOM   5870 C CB  . ALA B 2 95  ? 45.973  -26.672 55.756  1.00 99.70  ? 391 ALA B CB  1 
ATOM   5871 N N   . VAL B 2 96  ? 48.693  -25.638 54.977  1.00 89.71  ? 392 VAL B N   1 
ATOM   5872 C CA  . VAL B 2 96  ? 50.029  -25.097 55.242  1.00 92.75  ? 392 VAL B CA  1 
ATOM   5873 C C   . VAL B 2 96  ? 50.246  -23.767 54.521  1.00 99.75  ? 392 VAL B C   1 
ATOM   5874 O O   . VAL B 2 96  ? 50.898  -22.854 55.039  1.00 96.63  ? 392 VAL B O   1 
ATOM   5875 C CB  . VAL B 2 96  ? 51.104  -26.122 54.847  1.00 89.57  ? 392 VAL B CB  1 
ATOM   5876 C CG1 . VAL B 2 96  ? 52.466  -25.444 54.685  1.00 89.10  ? 392 VAL B CG1 1 
ATOM   5877 C CG2 . VAL B 2 96  ? 51.172  -27.218 55.866  1.00 93.80  ? 392 VAL B CG2 1 
ATOM   5878 N N   . GLN B 2 97  ? 49.715  -23.635 53.309  1.00 100.93 ? 393 GLN B N   1 
ATOM   5879 C CA  . GLN B 2 97  ? 49.851  -22.360 52.616  1.00 99.81  ? 393 GLN B CA  1 
ATOM   5880 C C   . GLN B 2 97  ? 49.017  -21.286 53.275  1.00 102.81 ? 393 GLN B C   1 
ATOM   5881 O O   . GLN B 2 97  ? 49.450  -20.132 53.373  1.00 105.55 ? 393 GLN B O   1 
ATOM   5882 C CB  . GLN B 2 97  ? 49.418  -22.491 51.180  1.00 96.03  ? 393 GLN B CB  1 
ATOM   5883 C CG  . GLN B 2 97  ? 50.187  -23.496 50.473  1.00 97.42  ? 393 GLN B CG  1 
ATOM   5884 C CD  . GLN B 2 97  ? 50.050  -23.350 48.998  1.00 96.15  ? 393 GLN B CD  1 
ATOM   5885 O OE1 . GLN B 2 97  ? 49.602  -24.283 48.333  1.00 95.24  ? 393 GLN B OE1 1 
ATOM   5886 N NE2 . GLN B 2 97  ? 50.461  -22.196 48.460  1.00 91.75  ? 393 GLN B NE2 1 
ATOM   5887 N N   . ALA B 2 98  ? 47.794  -21.634 53.678  1.00 100.30 ? 394 ALA B N   1 
ATOM   5888 C CA  . ALA B 2 98  ? 46.918  -20.639 54.275  1.00 99.98  ? 394 ALA B CA  1 
ATOM   5889 C C   . ALA B 2 98  ? 47.528  -20.105 55.561  1.00 102.56 ? 394 ALA B C   1 
ATOM   5890 O O   . ALA B 2 98  ? 47.502  -18.897 55.821  1.00 103.09 ? 394 ALA B O   1 
ATOM   5891 C CB  . ALA B 2 98  ? 45.532  -21.241 54.500  1.00 97.72  ? 394 ALA B CB  1 
ATOM   5892 N N   . ILE B 2 99  ? 48.133  -20.986 56.354  1.00 101.02 ? 395 ILE B N   1 
ATOM   5893 C CA  . ILE B 2 99  ? 48.841  -20.531 57.540  1.00 99.29  ? 395 ILE B CA  1 
ATOM   5894 C C   . ILE B 2 99  ? 49.956  -19.589 57.139  1.00 101.61 ? 395 ILE B C   1 
ATOM   5895 O O   . ILE B 2 99  ? 50.122  -18.513 57.718  1.00 111.62 ? 395 ILE B O   1 
ATOM   5896 C CB  . ILE B 2 99  ? 49.383  -21.738 58.325  1.00 101.27 ? 395 ILE B CB  1 
ATOM   5897 C CG1 . ILE B 2 99  ? 48.235  -22.514 58.970  1.00 99.31  ? 395 ILE B CG1 1 
ATOM   5898 C CG2 . ILE B 2 99  ? 50.356  -21.285 59.386  1.00 103.10 ? 395 ILE B CG2 1 
ATOM   5899 C CD1 . ILE B 2 99  ? 48.687  -23.775 59.651  1.00 98.47  ? 395 ILE B CD1 1 
ATOM   5900 N N   . ARG B 2 100 ? 50.719  -19.966 56.116  1.00 104.97 ? 396 ARG B N   1 
ATOM   5901 C CA  . ARG B 2 100 ? 51.843  -19.148 55.670  1.00 107.84 ? 396 ARG B CA  1 
ATOM   5902 C C   . ARG B 2 100 ? 51.400  -17.747 55.255  1.00 104.36 ? 396 ARG B C   1 
ATOM   5903 O O   . ARG B 2 100 ? 52.151  -16.784 55.434  1.00 99.34  ? 396 ARG B O   1 
ATOM   5904 C CB  . ARG B 2 100 ? 52.562  -19.872 54.524  1.00 107.52 ? 396 ARG B CB  1 
ATOM   5905 C CG  . ARG B 2 100 ? 53.787  -19.181 53.971  1.00 106.41 ? 396 ARG B CG  1 
ATOM   5906 C CD  . ARG B 2 100 ? 54.801  -18.883 55.050  1.00 106.60 ? 396 ARG B CD  1 
ATOM   5907 N NE  . ARG B 2 100 ? 55.761  -17.869 54.618  1.00 109.19 ? 396 ARG B NE  1 
ATOM   5908 C CZ  . ARG B 2 100 ? 55.472  -16.584 54.424  1.00 107.81 ? 396 ARG B CZ  1 
ATOM   5909 N NH1 . ARG B 2 100 ? 54.239  -16.143 54.624  1.00 107.84 ? 396 ARG B NH1 1 
ATOM   5910 N NH2 . ARG B 2 100 ? 56.418  -15.738 54.025  1.00 103.48 ? 396 ARG B NH2 1 
ATOM   5911 N N   . LYS B 2 101 ? 50.163  -17.617 54.800  1.00 105.84 ? 397 LYS B N   1 
ATOM   5912 C CA  . LYS B 2 101 ? 49.738  -16.294 54.291  1.00 107.06 ? 397 LYS B CA  1 
ATOM   5913 C C   . LYS B 2 101 ? 48.759  -15.640 55.248  1.00 109.46 ? 397 LYS B C   1 
ATOM   5914 O O   . LYS B 2 101 ? 48.476  -14.467 55.076  1.00 108.11 ? 397 LYS B O   1 
ATOM   5915 C CB  . LYS B 2 101 ? 49.063  -16.464 52.935  1.00 101.71 ? 397 LYS B CB  1 
ATOM   5916 C CG  . LYS B 2 101 ? 47.946  -15.487 52.636  1.00 102.53 ? 397 LYS B CG  1 
ATOM   5917 C CD  . LYS B 2 101 ? 47.898  -15.118 51.189  1.00 97.75  ? 397 LYS B CD  1 
ATOM   5918 C CE  . LYS B 2 101 ? 46.808  -14.126 50.873  1.00 98.54  ? 397 LYS B CE  1 
ATOM   5919 N NZ  . LYS B 2 101 ? 47.383  -12.803 50.546  1.00 107.37 ? 397 LYS B NZ  1 
ATOM   5920 N N   . TYR B 2 102 ? 48.269  -16.374 56.229  1.00 112.10 ? 398 TYR B N   1 
ATOM   5921 C CA  . TYR B 2 102 ? 47.303  -15.727 57.139  1.00 113.52 ? 398 TYR B CA  1 
ATOM   5922 C C   . TYR B 2 102 ? 47.858  -15.742 58.555  1.00 117.20 ? 398 TYR B C   1 
ATOM   5923 O O   . TYR B 2 102 ? 47.571  -14.839 59.324  1.00 120.46 ? 398 TYR B O   1 
ATOM   5924 C CB  . TYR B 2 102 ? 45.950  -16.398 56.982  1.00 107.92 ? 398 TYR B CB  1 
ATOM   5925 C CG  . TYR B 2 102 ? 45.320  -16.082 55.659  1.00 106.77 ? 398 TYR B CG  1 
ATOM   5926 C CD1 . TYR B 2 102 ? 44.710  -14.867 55.441  1.00 109.12 ? 398 TYR B CD1 1 
ATOM   5927 C CD2 . TYR B 2 102 ? 45.351  -16.984 54.624  1.00 107.52 ? 398 TYR B CD2 1 
ATOM   5928 C CE1 . TYR B 2 102 ? 44.121  -14.555 54.235  1.00 102.15 ? 398 TYR B CE1 1 
ATOM   5929 C CE2 . TYR B 2 102 ? 44.764  -16.691 53.410  1.00 108.00 ? 398 TYR B CE2 1 
ATOM   5930 C CZ  . TYR B 2 102 ? 44.152  -15.477 53.219  1.00 106.07 ? 398 TYR B CZ  1 
ATOM   5931 O OH  . TYR B 2 102 ? 43.580  -15.187 52.032  1.00 108.74 ? 398 TYR B OH  1 
ATOM   5932 N N   . GLY B 2 103 ? 48.656  -16.750 58.862  1.00 117.57 ? 399 GLY B N   1 
ATOM   5933 C CA  . GLY B 2 103 ? 49.270  -16.817 60.193  1.00 119.22 ? 399 GLY B CA  1 
ATOM   5934 C C   . GLY B 2 103 ? 48.365  -17.470 61.213  1.00 124.39 ? 399 GLY B C   1 
ATOM   5935 O O   . GLY B 2 103 ? 48.677  -18.575 61.642  1.00 120.12 ? 399 GLY B O   1 
ATOM   5936 N N   . ARG B 2 104 ? 47.272  -16.812 61.585  1.00 130.19 ? 400 ARG B N   1 
ATOM   5937 C CA  . ARG B 2 104 ? 46.404  -17.407 62.624  1.00 126.50 ? 400 ARG B CA  1 
ATOM   5938 C C   . ARG B 2 104 ? 44.954  -17.052 62.355  1.00 124.40 ? 400 ARG B C   1 
ATOM   5939 O O   . ARG B 2 104 ? 44.123  -17.497 63.122  1.00 126.64 ? 400 ARG B O   1 
ATOM   5940 C CB  . ARG B 2 104 ? 46.771  -16.847 63.997  1.00 119.64 ? 400 ARG B CB  1 
ATOM   5941 C CG  . ARG B 2 104 ? 48.019  -17.474 64.593  1.00 119.27 ? 400 ARG B CG  1 
ATOM   5942 C CD  . ARG B 2 104 ? 48.179  -17.270 66.078  1.00 117.47 ? 400 ARG B CD  1 
ATOM   5943 N NE  . ARG B 2 104 ? 49.432  -17.843 66.526  1.00 117.52 ? 400 ARG B NE  1 
ATOM   5944 C CZ  . ARG B 2 104 ? 50.596  -17.225 66.466  1.00 120.22 ? 400 ARG B CZ  1 
ATOM   5945 N NH1 . ARG B 2 104 ? 50.668  -16.001 65.980  1.00 111.61 ? 400 ARG B NH1 1 
ATOM   5946 N NH2 . ARG B 2 104 ? 51.683  -17.826 66.903  1.00 116.49 ? 400 ARG B NH2 1 
ATOM   5947 N N   . ASP B 2 105 ? 44.648  -16.425 61.229  1.00 119.05 ? 401 ASP B N   1 
ATOM   5948 C CA  . ASP B 2 105 ? 43.231  -16.037 61.049  1.00 121.57 ? 401 ASP B CA  1 
ATOM   5949 C C   . ASP B 2 105 ? 42.465  -17.304 60.694  1.00 121.97 ? 401 ASP B C   1 
ATOM   5950 O O   . ASP B 2 105 ? 42.175  -17.544 59.537  1.00 122.07 ? 401 ASP B O   1 
ATOM   5951 C CB  . ASP B 2 105 ? 43.092  -14.919 60.025  1.00 116.70 ? 401 ASP B CB  1 
ATOM   5952 C CG  . ASP B 2 105 ? 41.658  -14.541 59.730  1.00 125.09 ? 401 ASP B CG  1 
ATOM   5953 O OD1 . ASP B 2 105 ? 41.456  -13.427 59.242  1.00 122.59 ? 401 ASP B OD1 1 
ATOM   5954 O OD2 . ASP B 2 105 ? 40.765  -15.365 59.974  1.00 127.15 ? 401 ASP B OD2 1 
ATOM   5955 N N   . PHE B 2 106 ? 41.883  -17.863 61.725  1.00 123.67 ? 402 PHE B N   1 
ATOM   5956 C CA  . PHE B 2 106 ? 41.178  -19.152 61.722  1.00 124.76 ? 402 PHE B CA  1 
ATOM   5957 C C   . PHE B 2 106 ? 40.097  -19.149 60.643  1.00 122.85 ? 402 PHE B C   1 
ATOM   5958 O O   . PHE B 2 106 ? 40.020  -20.095 59.873  1.00 120.23 ? 402 PHE B O   1 
ATOM   5959 C CB  . PHE B 2 106 ? 40.478  -19.199 63.084  1.00 137.81 ? 402 PHE B CB  1 
ATOM   5960 C CG  . PHE B 2 106 ? 40.151  -17.837 63.680  1.00 144.85 ? 402 PHE B CG  1 
ATOM   5961 C CD1 . PHE B 2 106 ? 41.146  -17.032 64.210  1.00 138.66 ? 402 PHE B CD1 1 
ATOM   5962 C CD2 . PHE B 2 106 ? 38.861  -17.323 63.668  1.00 140.88 ? 402 PHE B CD2 1 
ATOM   5963 C CE1 . PHE B 2 106 ? 40.869  -15.774 64.723  1.00 134.32 ? 402 PHE B CE1 1 
ATOM   5964 C CE2 . PHE B 2 106 ? 38.583  -16.063 64.173  1.00 141.20 ? 402 PHE B CE2 1 
ATOM   5965 C CZ  . PHE B 2 106 ? 39.587  -15.292 64.707  1.00 142.96 ? 402 PHE B CZ  1 
ATOM   5966 N N   . GLN B 2 107 ? 39.320  -18.080 60.562  1.00 121.53 ? 403 GLN B N   1 
ATOM   5967 C CA  . GLN B 2 107 ? 38.193  -18.006 59.613  1.00 121.11 ? 403 GLN B CA  1 
ATOM   5968 C C   . GLN B 2 107 ? 38.731  -18.020 58.193  1.00 125.78 ? 403 GLN B C   1 
ATOM   5969 O O   . GLN B 2 107 ? 38.188  -18.735 57.353  1.00 125.77 ? 403 GLN B O   1 
ATOM   5970 C CB  . GLN B 2 107 ? 37.457  -16.696 59.858  1.00 117.91 ? 403 GLN B CB  1 
ATOM   5971 C CG  . GLN B 2 107 ? 36.002  -16.900 60.214  1.00 124.84 ? 403 GLN B CG  1 
ATOM   5972 C CD  . GLN B 2 107 ? 35.427  -17.974 59.336  1.00 131.61 ? 403 GLN B CD  1 
ATOM   5973 O OE1 . GLN B 2 107 ? 35.868  -18.172 58.219  1.00 135.79 ? 403 GLN B OE1 1 
ATOM   5974 N NE2 . GLN B 2 107 ? 34.439  -18.683 59.842  1.00 123.49 ? 403 GLN B NE2 1 
ATOM   5975 N N   . ALA B 2 108 ? 39.802  -17.277 57.959  1.00 123.80 ? 404 ALA B N   1 
ATOM   5976 C CA  . ALA B 2 108 ? 40.322  -17.205 56.586  1.00 116.12 ? 404 ALA B CA  1 
ATOM   5977 C C   . ALA B 2 108 ? 40.754  -18.599 56.171  1.00 120.25 ? 404 ALA B C   1 
ATOM   5978 O O   . ALA B 2 108 ? 40.255  -19.090 55.157  1.00 120.61 ? 404 ALA B O   1 
ATOM   5979 C CB  . ALA B 2 108 ? 41.491  -16.275 56.576  1.00 111.41 ? 404 ALA B CB  1 
ATOM   5980 N N   . ILE B 2 109 ? 41.493  -19.265 57.048  1.00 112.70 ? 405 ILE B N   1 
ATOM   5981 C CA  . ILE B 2 109 ? 41.994  -20.617 56.714  1.00 104.65 ? 405 ILE B CA  1 
ATOM   5982 C C   . ILE B 2 109 ? 40.796  -21.514 56.493  1.00 110.32 ? 405 ILE B C   1 
ATOM   5983 O O   . ILE B 2 109 ? 40.734  -22.095 55.451  1.00 114.26 ? 405 ILE B O   1 
ATOM   5984 C CB  . ILE B 2 109 ? 42.885  -21.121 57.838  1.00 92.80  ? 405 ILE B CB  1 
ATOM   5985 C CG1 . ILE B 2 109 ? 43.916  -20.055 58.185  1.00 95.73  ? 405 ILE B CG1 1 
ATOM   5986 C CG2 . ILE B 2 109 ? 43.541  -22.413 57.432  1.00 97.51  ? 405 ILE B CG2 1 
ATOM   5987 C CD1 . ILE B 2 109 ? 45.286  -20.608 58.372  1.00 102.62 ? 405 ILE B CD1 1 
ATOM   5988 N N   . SER B 2 110 ? 39.787  -21.456 57.349  1.00 115.40 ? 406 SER B N   1 
ATOM   5989 C CA  . SER B 2 110 ? 38.597  -22.296 57.070  1.00 119.99 ? 406 SER B CA  1 
ATOM   5990 C C   . SER B 2 110 ? 37.938  -21.830 55.777  1.00 121.07 ? 406 SER B C   1 
ATOM   5991 O O   . SER B 2 110 ? 37.495  -22.661 55.011  1.00 122.38 ? 406 SER B O   1 
ATOM   5992 C CB  . SER B 2 110 ? 37.613  -22.283 58.174  1.00 121.91 ? 406 SER B CB  1 
ATOM   5993 O OG  . SER B 2 110 ? 36.385  -22.798 57.692  1.00 122.99 ? 406 SER B OG  1 
ATOM   5994 N N   . ASP B 2 111 ? 37.890  -20.527 55.539  1.00 118.44 ? 407 ASP B N   1 
ATOM   5995 C CA  . ASP B 2 111 ? 37.265  -20.055 54.288  1.00 122.48 ? 407 ASP B CA  1 
ATOM   5996 C C   . ASP B 2 111 ? 38.049  -20.586 53.096  1.00 121.67 ? 407 ASP B C   1 
ATOM   5997 O O   . ASP B 2 111 ? 37.426  -20.960 52.119  1.00 126.19 ? 407 ASP B O   1 
ATOM   5998 C CB  . ASP B 2 111 ? 37.215  -18.536 54.262  1.00 131.56 ? 407 ASP B CB  1 
ATOM   5999 C CG  . ASP B 2 111 ? 36.017  -18.017 55.017  1.00 135.71 ? 407 ASP B CG  1 
ATOM   6000 O OD1 . ASP B 2 111 ? 35.151  -18.836 55.340  1.00 133.20 ? 407 ASP B OD1 1 
ATOM   6001 O OD2 . ASP B 2 111 ? 35.979  -16.814 55.292  1.00 131.26 ? 407 ASP B OD2 1 
ATOM   6002 N N   . VAL B 2 112 ? 39.367  -20.587 53.183  1.00 119.63 ? 408 VAL B N   1 
ATOM   6003 C CA  . VAL B 2 112 ? 40.147  -21.015 51.994  1.00 115.39 ? 408 VAL B CA  1 
ATOM   6004 C C   . VAL B 2 112 ? 39.832  -22.467 51.674  1.00 117.93 ? 408 VAL B C   1 
ATOM   6005 O O   . VAL B 2 112 ? 39.388  -22.736 50.572  1.00 118.82 ? 408 VAL B O   1 
ATOM   6006 C CB  . VAL B 2 112 ? 41.647  -20.814 52.217  1.00 113.39 ? 408 VAL B CB  1 
ATOM   6007 C CG1 . VAL B 2 112 ? 42.452  -21.683 51.286  1.00 117.02 ? 408 VAL B CG1 1 
ATOM   6008 C CG2 . VAL B 2 112 ? 42.019  -19.368 52.020  1.00 109.94 ? 408 VAL B CG2 1 
ATOM   6009 N N   . ILE B 2 113 ? 40.029  -23.359 52.629  1.00 108.89 ? 409 ILE B N   1 
ATOM   6010 C CA  . ILE B 2 113 ? 39.783  -24.793 52.347  1.00 106.78 ? 409 ILE B CA  1 
ATOM   6011 C C   . ILE B 2 113 ? 38.324  -24.971 51.949  1.00 116.44 ? 409 ILE B C   1 
ATOM   6012 O O   . ILE B 2 113 ? 38.044  -25.832 51.135  1.00 124.92 ? 409 ILE B O   1 
ATOM   6013 C CB  . ILE B 2 113 ? 40.168  -25.621 53.569  1.00 101.86 ? 409 ILE B CB  1 
ATOM   6014 C CG1 . ILE B 2 113 ? 41.227  -24.895 54.391  1.00 101.15 ? 409 ILE B CG1 1 
ATOM   6015 C CG2 . ILE B 2 113 ? 40.669  -26.970 53.130  1.00 107.05 ? 409 ILE B CG2 1 
ATOM   6016 C CD1 . ILE B 2 113 ? 42.503  -25.653 54.495  1.00 97.23  ? 409 ILE B CD1 1 
ATOM   6017 N N   . GLY B 2 114 ? 37.424  -24.202 52.552  1.00 119.15 ? 410 GLY B N   1 
ATOM   6018 C CA  . GLY B 2 114 ? 35.984  -24.226 52.226  1.00 123.42 ? 410 GLY B CA  1 
ATOM   6019 C C   . GLY B 2 114 ? 35.352  -25.600 52.291  1.00 127.03 ? 410 GLY B C   1 
ATOM   6020 O O   . GLY B 2 114 ? 34.453  -25.869 51.490  1.00 127.96 ? 410 GLY B O   1 
ATOM   6021 N N   . ASN B 2 115 ? 35.753  -26.407 53.263  1.00 129.23 ? 411 ASN B N   1 
ATOM   6022 C CA  . ASN B 2 115 ? 35.226  -27.782 53.409  1.00 132.72 ? 411 ASN B CA  1 
ATOM   6023 C C   . ASN B 2 115 ? 35.552  -28.227 54.826  1.00 131.69 ? 411 ASN B C   1 
ATOM   6024 O O   . ASN B 2 115 ? 34.863  -29.087 55.357  1.00 136.10 ? 411 ASN B O   1 
ATOM   6025 C CB  . ASN B 2 115 ? 35.843  -28.699 52.365  1.00 134.21 ? 411 ASN B CB  1 
ATOM   6026 C CG  . ASN B 2 115 ? 36.490  -29.914 52.972  1.00 132.64 ? 411 ASN B CG  1 
ATOM   6027 O OD1 . ASN B 2 115 ? 37.426  -29.807 53.749  1.00 130.67 ? 411 ASN B OD1 1 
ATOM   6028 N ND2 . ASN B 2 115 ? 35.996  -31.079 52.609  1.00 137.50 ? 411 ASN B ND2 1 
ATOM   6029 N N   . LYS B 2 116 ? 36.646  -27.718 55.359  1.00 126.37 ? 412 LYS B N   1 
ATOM   6030 C CA  . LYS B 2 116 ? 36.975  -27.990 56.771  1.00 127.01 ? 412 LYS B CA  1 
ATOM   6031 C C   . LYS B 2 116 ? 36.547  -26.761 57.582  1.00 132.26 ? 412 LYS B C   1 
ATOM   6032 O O   . LYS B 2 116 ? 36.323  -25.700 56.994  1.00 134.94 ? 412 LYS B O   1 
ATOM   6033 C CB  . LYS B 2 116 ? 38.433  -28.424 56.894  1.00 117.81 ? 412 LYS B CB  1 
ATOM   6034 C CG  . LYS B 2 116 ? 38.615  -29.932 56.929  1.00 122.51 ? 412 LYS B CG  1 
ATOM   6035 C CD  . LYS B 2 116 ? 39.644  -30.474 55.978  1.00 123.08 ? 412 LYS B CD  1 
ATOM   6036 C CE  . LYS B 2 116 ? 39.470  -31.952 55.714  1.00 124.89 ? 412 LYS B CE  1 
ATOM   6037 N NZ  . LYS B 2 116 ? 39.362  -32.247 54.267  1.00 127.44 ? 412 LYS B NZ  1 
ATOM   6038 N N   . SER B 2 117 ? 36.412  -26.893 58.897  1.00 130.66 ? 413 SER B N   1 
ATOM   6039 C CA  . SER B 2 117 ? 35.922  -25.737 59.681  1.00 133.70 ? 413 SER B CA  1 
ATOM   6040 C C   . SER B 2 117 ? 36.961  -25.242 60.681  1.00 130.87 ? 413 SER B C   1 
ATOM   6041 O O   . SER B 2 117 ? 38.015  -25.868 60.844  1.00 127.55 ? 413 SER B O   1 
ATOM   6042 C CB  . SER B 2 117 ? 34.598  -26.013 60.314  1.00 132.06 ? 413 SER B CB  1 
ATOM   6043 O OG  . SER B 2 117 ? 34.181  -24.914 61.100  1.00 131.38 ? 413 SER B OG  1 
ATOM   6044 N N   . VAL B 2 118 ? 36.606  -24.170 61.365  1.00 129.31 ? 414 VAL B N   1 
ATOM   6045 C CA  . VAL B 2 118 ? 37.523  -23.470 62.300  1.00 128.70 ? 414 VAL B CA  1 
ATOM   6046 C C   . VAL B 2 118 ? 37.858  -24.413 63.433  1.00 130.75 ? 414 VAL B C   1 
ATOM   6047 O O   . VAL B 2 118 ? 38.978  -24.322 63.952  1.00 127.30 ? 414 VAL B O   1 
ATOM   6048 C CB  . VAL B 2 118 ? 36.885  -22.200 62.869  1.00 120.92 ? 414 VAL B CB  1 
ATOM   6049 C CG1 . VAL B 2 118 ? 37.938  -21.155 63.165  1.00 119.17 ? 414 VAL B CG1 1 
ATOM   6050 C CG2 . VAL B 2 118 ? 35.803  -21.654 61.958  1.00 117.06 ? 414 VAL B CG2 1 
ATOM   6051 N N   . VAL B 2 119 ? 36.907  -25.266 63.809  1.00 133.79 ? 415 VAL B N   1 
ATOM   6052 C CA  . VAL B 2 119 ? 37.365  -26.159 64.901  1.00 138.15 ? 415 VAL B CA  1 
ATOM   6053 C C   . VAL B 2 119 ? 38.430  -27.097 64.336  1.00 137.01 ? 415 VAL B C   1 
ATOM   6054 O O   . VAL B 2 119 ? 39.518  -27.145 64.929  1.00 134.26 ? 415 VAL B O   1 
ATOM   6055 C CB  . VAL B 2 119 ? 36.190  -26.890 65.573  1.00 135.69 ? 415 VAL B CB  1 
ATOM   6056 C CG1 . VAL B 2 119 ? 34.926  -26.839 64.736  1.00 130.09 ? 415 VAL B CG1 1 
ATOM   6057 C CG2 . VAL B 2 119 ? 36.536  -28.315 65.959  1.00 132.33 ? 415 VAL B CG2 1 
ATOM   6058 N N   . GLN B 2 120 ? 38.143  -27.745 63.203  1.00 134.37 ? 416 GLN B N   1 
ATOM   6059 C CA  . GLN B 2 120 ? 39.119  -28.696 62.622  1.00 131.58 ? 416 GLN B CA  1 
ATOM   6060 C C   . GLN B 2 120 ? 40.397  -27.928 62.371  1.00 129.28 ? 416 GLN B C   1 
ATOM   6061 O O   . GLN B 2 120 ? 41.445  -28.366 62.859  1.00 130.08 ? 416 GLN B O   1 
ATOM   6062 C CB  . GLN B 2 120 ? 38.680  -29.176 61.250  1.00 123.88 ? 416 GLN B CB  1 
ATOM   6063 C CG  . GLN B 2 120 ? 37.407  -29.984 61.283  1.00 127.41 ? 416 GLN B CG  1 
ATOM   6064 C CD  . GLN B 2 120 ? 36.272  -29.005 61.352  1.00 133.31 ? 416 GLN B CD  1 
ATOM   6065 O OE1 . GLN B 2 120 ? 36.320  -28.034 62.097  1.00 134.18 ? 416 GLN B OE1 1 
ATOM   6066 N NE2 . GLN B 2 120 ? 35.264  -29.241 60.536  1.00 130.10 ? 416 GLN B NE2 1 
ATOM   6067 N N   . VAL B 2 121 ? 40.244  -26.813 61.664  1.00 128.55 ? 417 VAL B N   1 
ATOM   6068 C CA  . VAL B 2 121 ? 41.386  -25.924 61.338  1.00 128.46 ? 417 VAL B CA  1 
ATOM   6069 C C   . VAL B 2 121 ? 42.104  -25.646 62.639  1.00 130.14 ? 417 VAL B C   1 
ATOM   6070 O O   . VAL B 2 121 ? 43.305  -25.915 62.704  1.00 123.88 ? 417 VAL B O   1 
ATOM   6071 C CB  . VAL B 2 121 ? 40.915  -24.591 60.749  1.00 124.17 ? 417 VAL B CB  1 
ATOM   6072 C CG1 . VAL B 2 121 ? 41.970  -23.524 60.934  1.00 112.70 ? 417 VAL B CG1 1 
ATOM   6073 C CG2 . VAL B 2 121 ? 40.553  -24.734 59.291  1.00 123.63 ? 417 VAL B CG2 1 
ATOM   6074 N N   . LYS B 2 122 ? 41.358  -25.203 63.645  1.00 133.98 ? 418 LYS B N   1 
ATOM   6075 C CA  . LYS B 2 122 ? 42.115  -24.911 64.890  1.00 132.07 ? 418 LYS B CA  1 
ATOM   6076 C C   . LYS B 2 122 ? 42.747  -26.185 65.450  1.00 132.13 ? 418 LYS B C   1 
ATOM   6077 O O   . LYS B 2 122 ? 43.920  -26.138 65.816  1.00 127.94 ? 418 LYS B O   1 
ATOM   6078 C CB  . LYS B 2 122 ? 41.249  -24.133 65.881  1.00 126.44 ? 418 LYS B CB  1 
ATOM   6079 C CG  . LYS B 2 122 ? 41.021  -22.668 65.522  1.00 132.82 ? 418 LYS B CG  1 
ATOM   6080 C CD  . LYS B 2 122 ? 42.259  -21.908 65.042  1.00 134.57 ? 418 LYS B CD  1 
ATOM   6081 C CE  . LYS B 2 122 ? 41.962  -20.881 63.963  1.00 128.82 ? 418 LYS B CE  1 
ATOM   6082 N NZ  . LYS B 2 122 ? 42.976  -19.804 63.891  1.00 118.02 ? 418 LYS B NZ  1 
ATOM   6083 N N   . ASN B 2 123 ? 41.993  -27.277 65.484  1.00 132.65 ? 419 ASN B N   1 
ATOM   6084 C CA  . ASN B 2 123 ? 42.542  -28.563 65.963  1.00 135.29 ? 419 ASN B CA  1 
ATOM   6085 C C   . ASN B 2 123 ? 43.796  -28.888 65.156  1.00 132.98 ? 419 ASN B C   1 
ATOM   6086 O O   . ASN B 2 123 ? 44.882  -29.011 65.742  1.00 128.83 ? 419 ASN B O   1 
ATOM   6087 C CB  . ASN B 2 123 ? 41.519  -29.674 65.739  1.00 135.99 ? 419 ASN B CB  1 
ATOM   6088 C CG  . ASN B 2 123 ? 41.260  -30.488 66.984  1.00 138.65 ? 419 ASN B CG  1 
ATOM   6089 O OD1 . ASN B 2 123 ? 41.469  -30.011 68.093  1.00 138.40 ? 419 ASN B OD1 1 
ATOM   6090 N ND2 . ASN B 2 123 ? 40.817  -31.719 66.806  1.00 132.97 ? 419 ASN B ND2 1 
ATOM   6091 N N   . PHE B 2 124 ? 43.653  -28.883 63.833  1.00 133.25 ? 420 PHE B N   1 
ATOM   6092 C CA  . PHE B 2 124 ? 44.693  -29.288 62.848  1.00 133.39 ? 420 PHE B CA  1 
ATOM   6093 C C   . PHE B 2 124 ? 46.119  -28.851 63.205  1.00 131.27 ? 420 PHE B C   1 
ATOM   6094 O O   . PHE B 2 124 ? 46.999  -29.702 63.088  1.00 127.42 ? 420 PHE B O   1 
ATOM   6095 C CB  . PHE B 2 124 ? 44.206  -29.010 61.426  1.00 131.74 ? 420 PHE B CB  1 
ATOM   6096 C CG  . PHE B 2 124 ? 45.202  -29.166 60.312  1.00 127.98 ? 420 PHE B CG  1 
ATOM   6097 C CD1 . PHE B 2 124 ? 44.857  -29.849 59.167  1.00 125.47 ? 420 PHE B CD1 1 
ATOM   6098 C CD2 . PHE B 2 124 ? 46.450  -28.589 60.386  1.00 126.37 ? 420 PHE B CD2 1 
ATOM   6099 C CE1 . PHE B 2 124 ? 45.761  -29.980 58.132  1.00 121.76 ? 420 PHE B CE1 1 
ATOM   6100 C CE2 . PHE B 2 124 ? 47.348  -28.710 59.342  1.00 116.88 ? 420 PHE B CE2 1 
ATOM   6101 C CZ  . PHE B 2 124 ? 47.003  -29.411 58.223  1.00 115.82 ? 420 PHE B CZ  1 
ATOM   6102 N N   . PHE B 2 125 ? 46.348  -27.620 63.663  1.00 129.33 ? 421 PHE B N   1 
ATOM   6103 C CA  . PHE B 2 125 ? 47.728  -27.199 64.011  1.00 126.98 ? 421 PHE B CA  1 
ATOM   6104 C C   . PHE B 2 125 ? 48.344  -28.145 65.031  1.00 131.00 ? 421 PHE B C   1 
ATOM   6105 O O   . PHE B 2 125 ? 49.513  -28.501 64.900  1.00 128.52 ? 421 PHE B O   1 
ATOM   6106 C CB  . PHE B 2 125 ? 47.740  -25.854 64.724  1.00 117.68 ? 421 PHE B CB  1 
ATOM   6107 C CG  . PHE B 2 125 ? 47.080  -24.749 63.958  1.00 123.60 ? 421 PHE B CG  1 
ATOM   6108 C CD1 . PHE B 2 125 ? 45.793  -24.905 63.497  1.00 129.50 ? 421 PHE B CD1 1 
ATOM   6109 C CD2 . PHE B 2 125 ? 47.741  -23.565 63.697  1.00 118.73 ? 421 PHE B CD2 1 
ATOM   6110 C CE1 . PHE B 2 125 ? 45.173  -23.897 62.782  1.00 128.58 ? 421 PHE B CE1 1 
ATOM   6111 C CE2 . PHE B 2 125 ? 47.122  -22.557 62.984  1.00 120.24 ? 421 PHE B CE2 1 
ATOM   6112 C CZ  . PHE B 2 125 ? 45.840  -22.726 62.530  1.00 122.21 ? 421 PHE B CZ  1 
ATOM   6113 N N   . VAL B 2 126 ? 47.582  -28.506 66.052  1.00 133.01 ? 422 VAL B N   1 
ATOM   6114 C CA  . VAL B 2 126 ? 48.189  -29.381 67.083  1.00 134.93 ? 422 VAL B CA  1 
ATOM   6115 C C   . VAL B 2 126 ? 48.308  -30.800 66.546  1.00 133.11 ? 422 VAL B C   1 
ATOM   6116 O O   . VAL B 2 126 ? 49.275  -31.442 66.904  1.00 137.73 ? 422 VAL B O   1 
ATOM   6117 C CB  . VAL B 2 126 ? 47.417  -29.310 68.405  1.00 134.47 ? 422 VAL B CB  1 
ATOM   6118 C CG1 . VAL B 2 126 ? 48.385  -29.274 69.574  1.00 124.72 ? 422 VAL B CG1 1 
ATOM   6119 C CG2 . VAL B 2 126 ? 46.516  -28.089 68.429  1.00 127.44 ? 422 VAL B CG2 1 
ATOM   6120 N N   . ASN B 2 127 ? 47.366  -31.255 65.728  1.00 130.64 ? 423 ASN B N   1 
ATOM   6121 C CA  . ASN B 2 127 ? 47.473  -32.642 65.212  1.00 133.09 ? 423 ASN B CA  1 
ATOM   6122 C C   . ASN B 2 127 ? 48.690  -32.719 64.309  1.00 131.00 ? 423 ASN B C   1 
ATOM   6123 O O   . ASN B 2 127 ? 49.653  -33.409 64.636  1.00 128.03 ? 423 ASN B O   1 
ATOM   6124 C CB  . ASN B 2 127 ? 46.247  -33.013 64.393  1.00 134.26 ? 423 ASN B CB  1 
ATOM   6125 C CG  . ASN B 2 127 ? 45.027  -32.353 64.975  1.00 133.72 ? 423 ASN B CG  1 
ATOM   6126 O OD1 . ASN B 2 127 ? 45.031  -32.008 66.144  1.00 133.57 ? 423 ASN B OD1 1 
ATOM   6127 N ND2 . ASN B 2 127 ? 43.998  -32.170 64.173  1.00 127.90 ? 423 ASN B ND2 1 
ATOM   6128 N N   . TYR B 2 128 ? 48.630  -32.034 63.182  1.00 132.12 ? 424 TYR B N   1 
ATOM   6129 C CA  . TYR B 2 128 ? 49.807  -32.025 62.293  1.00 131.51 ? 424 TYR B CA  1 
ATOM   6130 C C   . TYR B 2 128 ? 50.680  -30.902 62.815  1.00 125.82 ? 424 TYR B C   1 
ATOM   6131 O O   . TYR B 2 128 ? 50.558  -29.793 62.341  1.00 117.50 ? 424 TYR B O   1 
ATOM   6132 C CB  . TYR B 2 128 ? 49.340  -31.828 60.860  1.00 120.29 ? 424 TYR B CB  1 
ATOM   6133 C CG  . TYR B 2 128 ? 48.540  -33.001 60.379  1.00 122.09 ? 424 TYR B CG  1 
ATOM   6134 C CD1 . TYR B 2 128 ? 47.220  -32.864 60.013  1.00 122.82 ? 424 TYR B CD1 1 
ATOM   6135 C CD2 . TYR B 2 128 ? 49.100  -34.261 60.343  1.00 121.73 ? 424 TYR B CD2 1 
ATOM   6136 C CE1 . TYR B 2 128 ? 46.479  -33.949 59.587  1.00 124.80 ? 424 TYR B CE1 1 
ATOM   6137 C CE2 . TYR B 2 128 ? 48.377  -35.358 59.915  1.00 123.69 ? 424 TYR B CE2 1 
ATOM   6138 C CZ  . TYR B 2 128 ? 47.061  -35.198 59.534  1.00 126.28 ? 424 TYR B CZ  1 
ATOM   6139 O OH  . TYR B 2 128 ? 46.338  -36.273 59.116  1.00 126.72 ? 424 TYR B OH  1 
ATOM   6140 N N   . ARG B 2 129 ? 51.500  -31.203 63.810  1.00 128.87 ? 425 ARG B N   1 
ATOM   6141 C CA  . ARG B 2 129 ? 52.293  -30.132 64.435  1.00 129.47 ? 425 ARG B CA  1 
ATOM   6142 C C   . ARG B 2 129 ? 53.747  -30.344 64.070  1.00 123.84 ? 425 ARG B C   1 
ATOM   6143 O O   . ARG B 2 129 ? 54.266  -29.520 63.341  1.00 110.36 ? 425 ARG B O   1 
ATOM   6144 C CB  . ARG B 2 129 ? 52.066  -30.158 65.947  1.00 137.51 ? 425 ARG B CB  1 
ATOM   6145 C CG  . ARG B 2 129 ? 52.679  -28.994 66.710  1.00 139.37 ? 425 ARG B CG  1 
ATOM   6146 C CD  . ARG B 2 129 ? 52.687  -27.687 65.955  1.00 132.03 ? 425 ARG B CD  1 
ATOM   6147 N NE  . ARG B 2 129 ? 52.589  -26.533 66.830  1.00 139.20 ? 425 ARG B NE  1 
ATOM   6148 C CZ  . ARG B 2 129 ? 53.241  -26.395 67.971  1.00 142.11 ? 425 ARG B CZ  1 
ATOM   6149 N NH1 . ARG B 2 129 ? 54.046  -27.350 68.397  1.00 143.06 ? 425 ARG B NH1 1 
ATOM   6150 N NH2 . ARG B 2 129 ? 53.081  -25.300 68.689  1.00 137.85 ? 425 ARG B NH2 1 
ATOM   6151 N N   . ARG B 2 130 ? 54.410  -31.370 64.572  1.00 133.56 ? 426 ARG B N   1 
ATOM   6152 C CA  . ARG B 2 130 ? 55.834  -31.462 64.172  1.00 134.24 ? 426 ARG B CA  1 
ATOM   6153 C C   . ARG B 2 130 ? 55.875  -31.779 62.682  1.00 127.99 ? 426 ARG B C   1 
ATOM   6154 O O   . ARG B 2 130 ? 56.810  -31.355 62.007  1.00 122.97 ? 426 ARG B O   1 
ATOM   6155 C CB  . ARG B 2 130 ? 56.571  -32.559 64.947  1.00 136.79 ? 426 ARG B CB  1 
ATOM   6156 C CG  . ARG B 2 130 ? 56.149  -32.722 66.399  1.00 138.55 ? 426 ARG B CG  1 
ATOM   6157 C CD  . ARG B 2 130 ? 55.559  -34.098 66.638  1.00 146.30 ? 426 ARG B CD  1 
ATOM   6158 N NE  . ARG B 2 130 ? 54.340  -34.290 65.865  1.00 155.90 ? 426 ARG B NE  1 
ATOM   6159 C CZ  . ARG B 2 130 ? 53.486  -35.284 66.051  1.00 150.88 ? 426 ARG B CZ  1 
ATOM   6160 N NH1 . ARG B 2 130 ? 53.719  -36.186 66.988  1.00 148.91 ? 426 ARG B NH1 1 
ATOM   6161 N NH2 . ARG B 2 130 ? 52.403  -35.368 65.301  1.00 142.83 ? 426 ARG B NH2 1 
ATOM   6162 N N   . ARG B 2 131 ? 54.835  -32.451 62.201  1.00 128.88 ? 427 ARG B N   1 
ATOM   6163 C CA  . ARG B 2 131 ? 54.790  -32.954 60.808  1.00 125.70 ? 427 ARG B CA  1 
ATOM   6164 C C   . ARG B 2 131 ? 54.851  -31.813 59.799  1.00 119.27 ? 427 ARG B C   1 
ATOM   6165 O O   . ARG B 2 131 ? 55.520  -31.972 58.791  1.00 114.41 ? 427 ARG B O   1 
ATOM   6166 C CB  . ARG B 2 131 ? 53.521  -33.782 60.628  1.00 121.42 ? 427 ARG B CB  1 
ATOM   6167 C CG  . ARG B 2 131 ? 52.420  -33.408 61.606  1.00 128.77 ? 427 ARG B CG  1 
ATOM   6168 C CD  . ARG B 2 131 ? 51.734  -34.614 62.211  1.00 124.58 ? 427 ARG B CD  1 
ATOM   6169 N NE  . ARG B 2 131 ? 52.040  -35.869 61.545  1.00 117.22 ? 427 ARG B NE  1 
ATOM   6170 C CZ  . ARG B 2 131 ? 51.132  -36.628 60.963  1.00 117.44 ? 427 ARG B CZ  1 
ATOM   6171 N NH1 . ARG B 2 131 ? 49.871  -36.242 60.942  1.00 117.00 ? 427 ARG B NH1 1 
ATOM   6172 N NH2 . ARG B 2 131 ? 51.488  -37.760 60.391  1.00 115.28 ? 427 ARG B NH2 1 
ATOM   6173 N N   . PHE B 2 132 ? 54.155  -30.715 60.042  1.00 114.65 ? 428 PHE B N   1 
ATOM   6174 C CA  . PHE B 2 132 ? 54.202  -29.644 59.025  1.00 108.76 ? 428 PHE B CA  1 
ATOM   6175 C C   . PHE B 2 132 ? 55.057  -28.470 59.475  1.00 107.49 ? 428 PHE B C   1 
ATOM   6176 O O   . PHE B 2 132 ? 54.951  -27.456 58.833  1.00 106.65 ? 428 PHE B O   1 
ATOM   6177 C CB  . PHE B 2 132 ? 52.798  -29.207 58.636  1.00 104.71 ? 428 PHE B CB  1 
ATOM   6178 C CG  . PHE B 2 132 ? 52.139  -30.196 57.719  1.00 104.47 ? 428 PHE B CG  1 
ATOM   6179 C CD1 . PHE B 2 132 ? 52.893  -31.159 57.086  1.00 102.39 ? 428 PHE B CD1 1 
ATOM   6180 C CD2 . PHE B 2 132 ? 50.779  -30.181 57.509  1.00 104.13 ? 428 PHE B CD2 1 
ATOM   6181 C CE1 . PHE B 2 132 ? 52.299  -32.079 56.246  1.00 100.93 ? 428 PHE B CE1 1 
ATOM   6182 C CE2 . PHE B 2 132 ? 50.187  -31.106 56.672  1.00 105.48 ? 428 PHE B CE2 1 
ATOM   6183 C CZ  . PHE B 2 132 ? 50.947  -32.052 56.044  1.00 102.10 ? 428 PHE B CZ  1 
ATOM   6184 N N   . ASN B 2 133 ? 55.772  -28.576 60.590  1.00 113.39 ? 429 ASN B N   1 
ATOM   6185 C CA  . ASN B 2 133 ? 56.646  -27.473 61.071  1.00 113.28 ? 429 ASN B CA  1 
ATOM   6186 C C   . ASN B 2 133 ? 55.864  -26.170 61.160  1.00 111.88 ? 429 ASN B C   1 
ATOM   6187 O O   . ASN B 2 133 ? 56.413  -25.144 60.811  1.00 113.64 ? 429 ASN B O   1 
ATOM   6188 C CB  . ASN B 2 133 ? 57.866  -27.290 60.184  1.00 108.31 ? 429 ASN B CB  1 
ATOM   6189 C CG  . ASN B 2 133 ? 58.680  -28.556 60.102  1.00 112.21 ? 429 ASN B CG  1 
ATOM   6190 O OD1 . ASN B 2 133 ? 59.801  -28.609 60.583  1.00 116.75 ? 429 ASN B OD1 1 
ATOM   6191 N ND2 . ASN B 2 133 ? 58.106  -29.586 59.516  1.00 112.67 ? 429 ASN B ND2 1 
ATOM   6192 N N   . ILE B 2 134 ? 54.663  -26.205 61.724  1.00 113.49 ? 430 ILE B N   1 
ATOM   6193 C CA  . ILE B 2 134 ? 53.775  -25.016 61.750  1.00 111.19 ? 430 ILE B CA  1 
ATOM   6194 C C   . ILE B 2 134 ? 54.446  -23.882 62.508  1.00 115.73 ? 430 ILE B C   1 
ATOM   6195 O O   . ILE B 2 134 ? 54.417  -22.764 62.008  1.00 114.61 ? 430 ILE B O   1 
ATOM   6196 C CB  . ILE B 2 134 ? 52.432  -25.427 62.342  1.00 97.96  ? 430 ILE B CB  1 
ATOM   6197 C CG1 . ILE B 2 134 ? 51.983  -26.723 61.684  1.00 103.42 ? 430 ILE B CG1 1 
ATOM   6198 C CG2 . ILE B 2 134 ? 51.416  -24.337 62.137  1.00 96.79  ? 430 ILE B CG2 1 
ATOM   6199 C CD1 . ILE B 2 134 ? 51.110  -27.569 62.548  1.00 117.06 ? 430 ILE B CD1 1 
ATOM   6200 N N   . ASP B 2 135 ? 55.142  -24.196 63.596  1.00 119.31 ? 431 ASP B N   1 
ATOM   6201 C CA  . ASP B 2 135 ? 55.840  -23.154 64.380  1.00 124.07 ? 431 ASP B CA  1 
ATOM   6202 C C   . ASP B 2 135 ? 56.820  -22.443 63.452  1.00 121.17 ? 431 ASP B C   1 
ATOM   6203 O O   . ASP B 2 135 ? 56.741  -21.217 63.363  1.00 116.46 ? 431 ASP B O   1 
ATOM   6204 C CB  . ASP B 2 135 ? 56.696  -23.809 65.465  1.00 134.80 ? 431 ASP B CB  1 
ATOM   6205 C CG  . ASP B 2 135 ? 55.932  -24.311 66.675  1.00 140.32 ? 431 ASP B CG  1 
ATOM   6206 O OD1 . ASP B 2 135 ? 54.829  -23.796 66.928  1.00 136.76 ? 431 ASP B OD1 1 
ATOM   6207 O OD2 . ASP B 2 135 ? 56.463  -25.201 67.362  1.00 138.70 ? 431 ASP B OD2 1 
ATOM   6208 N N   . GLU B 2 136 ? 57.587  -23.197 62.663  1.00 120.60 ? 432 GLU B N   1 
ATOM   6209 C CA  . GLU B 2 136 ? 58.548  -22.562 61.735  1.00 116.73 ? 432 GLU B CA  1 
ATOM   6210 C C   . GLU B 2 136 ? 57.757  -21.700 60.763  1.00 114.46 ? 432 GLU B C   1 
ATOM   6211 O O   . GLU B 2 136 ? 58.106  -20.546 60.595  1.00 116.65 ? 432 GLU B O   1 
ATOM   6212 C CB  . GLU B 2 136 ? 59.258  -23.645 60.934  1.00 110.49 ? 432 GLU B CB  1 
ATOM   6213 C CG  . GLU B 2 136 ? 60.751  -23.443 60.837  1.00 115.98 ? 432 GLU B CG  1 
ATOM   6214 C CD  . GLU B 2 136 ? 61.533  -24.732 60.704  1.00 117.97 ? 432 GLU B CD  1 
ATOM   6215 O OE1 . GLU B 2 136 ? 62.761  -24.683 60.728  1.00 120.88 ? 432 GLU B OE1 1 
ATOM   6216 O OE2 . GLU B 2 136 ? 60.904  -25.778 60.584  1.00 124.11 ? 432 GLU B OE2 1 
ATOM   6217 N N   . VAL B 2 137 ? 56.669  -22.237 60.238  1.00 112.52 ? 433 VAL B N   1 
ATOM   6218 C CA  . VAL B 2 137 ? 55.856  -21.473 59.266  1.00 114.01 ? 433 VAL B CA  1 
ATOM   6219 C C   . VAL B 2 137 ? 55.387  -20.189 59.927  1.00 116.48 ? 433 VAL B C   1 
ATOM   6220 O O   . VAL B 2 137 ? 55.700  -19.128 59.396  1.00 117.48 ? 433 VAL B O   1 
ATOM   6221 C CB  . VAL B 2 137 ? 54.649  -22.308 58.828  1.00 110.49 ? 433 VAL B CB  1 
ATOM   6222 C CG1 . VAL B 2 137 ? 53.552  -21.430 58.273  1.00 109.09 ? 433 VAL B CG1 1 
ATOM   6223 C CG2 . VAL B 2 137 ? 55.051  -23.356 57.818  1.00 104.98 ? 433 VAL B CG2 1 
ATOM   6224 N N   . LEU B 2 138 ? 54.737  -20.312 61.078  1.00 117.26 ? 434 LEU B N   1 
ATOM   6225 C CA  . LEU B 2 138 ? 54.135  -19.132 61.738  1.00 113.35 ? 434 LEU B CA  1 
ATOM   6226 C C   . LEU B 2 138 ? 55.168  -18.038 61.933  1.00 117.32 ? 434 LEU B C   1 
ATOM   6227 O O   . LEU B 2 138 ? 54.813  -16.883 61.724  1.00 120.56 ? 434 LEU B O   1 
ATOM   6228 C CB  . LEU B 2 138 ? 53.505  -19.560 63.051  1.00 111.62 ? 434 LEU B CB  1 
ATOM   6229 C CG  . LEU B 2 138 ? 52.207  -20.318 62.842  1.00 117.20 ? 434 LEU B CG  1 
ATOM   6230 C CD1 . LEU B 2 138 ? 52.100  -21.464 63.818  1.00 114.11 ? 434 LEU B CD1 1 
ATOM   6231 C CD2 . LEU B 2 138 ? 51.013  -19.391 62.944  1.00 115.01 ? 434 LEU B CD2 1 
ATOM   6232 N N   . GLN B 2 139 ? 56.410  -18.389 62.265  1.00 117.29 ? 435 GLN B N   1 
ATOM   6233 C CA  . GLN B 2 139 ? 57.426  -17.327 62.422  1.00 118.94 ? 435 GLN B CA  1 
ATOM   6234 C C   . GLN B 2 139 ? 57.550  -16.604 61.085  1.00 121.38 ? 435 GLN B C   1 
ATOM   6235 O O   . GLN B 2 139 ? 57.461  -15.370 61.089  1.00 118.36 ? 435 GLN B O   1 
ATOM   6236 C CB  . GLN B 2 139 ? 58.779  -17.947 62.741  1.00 115.96 ? 435 GLN B CB  1 
ATOM   6237 C CG  . GLN B 2 139 ? 58.708  -19.061 63.765  1.00 124.24 ? 435 GLN B CG  1 
ATOM   6238 C CD  . GLN B 2 139 ? 60.081  -19.618 64.040  1.00 131.17 ? 435 GLN B CD  1 
ATOM   6239 O OE1 . GLN B 2 139 ? 60.241  -20.681 64.628  1.00 129.33 ? 435 GLN B OE1 1 
ATOM   6240 N NE2 . GLN B 2 139 ? 61.094  -18.893 63.606  1.00 132.90 ? 435 GLN B NE2 1 
ATOM   6241 N N   . GLU B 2 140 ? 57.636  -17.362 59.992  1.00 119.61 ? 436 GLU B N   1 
ATOM   6242 C CA  . GLU B 2 140 ? 57.704  -16.753 58.651  1.00 119.23 ? 436 GLU B CA  1 
ATOM   6243 C C   . GLU B 2 140 ? 56.496  -15.835 58.471  1.00 123.12 ? 436 GLU B C   1 
ATOM   6244 O O   . GLU B 2 140 ? 56.703  -14.742 57.966  1.00 125.73 ? 436 GLU B O   1 
ATOM   6245 C CB  . GLU B 2 140 ? 57.791  -17.824 57.570  1.00 119.60 ? 436 GLU B CB  1 
ATOM   6246 C CG  . GLU B 2 140 ? 59.204  -18.292 57.301  1.00 117.52 ? 436 GLU B CG  1 
ATOM   6247 C CD  . GLU B 2 140 ? 59.938  -17.452 56.278  1.00 125.76 ? 436 GLU B CD  1 
ATOM   6248 O OE1 . GLU B 2 140 ? 61.116  -17.744 55.988  1.00 122.39 ? 436 GLU B OE1 1 
ATOM   6249 O OE2 . GLU B 2 140 ? 59.325  -16.504 55.777  1.00 126.93 ? 436 GLU B OE2 1 
ATOM   6250 N N   . TRP B 2 141 ? 55.299  -16.220 58.916  1.00 119.55 ? 437 TRP B N   1 
ATOM   6251 C CA  . TRP B 2 141 ? 54.215  -15.275 58.686  1.00 120.19 ? 437 TRP B CA  1 
ATOM   6252 C C   . TRP B 2 141 ? 54.424  -13.987 59.469  1.00 123.59 ? 437 TRP B C   1 
ATOM   6253 O O   . TRP B 2 141 ? 54.163  -12.887 58.956  1.00 123.23 ? 437 TRP B O   1 
ATOM   6254 C CB  . TRP B 2 141 ? 52.873  -15.891 59.054  1.00 121.04 ? 437 TRP B CB  1 
ATOM   6255 C CG  . TRP B 2 141 ? 51.789  -14.878 58.975  1.00 122.18 ? 437 TRP B CG  1 
ATOM   6256 C CD1 . TRP B 2 141 ? 51.250  -14.348 57.840  1.00 122.03 ? 437 TRP B CD1 1 
ATOM   6257 C CD2 . TRP B 2 141 ? 51.124  -14.242 60.069  1.00 127.21 ? 437 TRP B CD2 1 
ATOM   6258 N NE1 . TRP B 2 141 ? 50.282  -13.427 58.155  1.00 123.25 ? 437 TRP B NE1 1 
ATOM   6259 C CE2 . TRP B 2 141 ? 50.180  -13.347 59.519  1.00 127.42 ? 437 TRP B CE2 1 
ATOM   6260 C CE3 . TRP B 2 141 ? 51.224  -14.349 61.462  1.00 128.36 ? 437 TRP B CE3 1 
ATOM   6261 C CZ2 . TRP B 2 141 ? 49.341  -12.564 60.312  1.00 128.90 ? 437 TRP B CZ2 1 
ATOM   6262 C CZ3 . TRP B 2 141 ? 50.388  -13.570 62.249  1.00 128.79 ? 437 TRP B CZ3 1 
ATOM   6263 C CH2 . TRP B 2 141 ? 49.458  -12.690 61.671  1.00 129.02 ? 437 TRP B CH2 1 
ATOM   6264 N N   . GLU B 2 142 ? 54.906  -14.104 60.712  1.00 123.85 ? 438 GLU B N   1 
ATOM   6265 C CA  . GLU B 2 142 ? 55.057  -12.923 61.559  1.00 131.17 ? 438 GLU B CA  1 
ATOM   6266 C C   . GLU B 2 142 ? 56.139  -11.982 61.024  1.00 129.36 ? 438 GLU B C   1 
ATOM   6267 O O   . GLU B 2 142 ? 56.062  -10.762 61.245  1.00 127.17 ? 438 GLU B O   1 
ATOM   6268 C CB  . GLU B 2 142 ? 55.330  -13.358 63.009  1.00 130.08 ? 438 GLU B CB  1 
ATOM   6269 C CG  . GLU B 2 142 ? 54.224  -14.292 63.571  1.00 130.44 ? 438 GLU B CG  1 
ATOM   6270 C CD  . GLU B 2 142 ? 54.221  -14.454 65.095  1.00 129.17 ? 438 GLU B CD  1 
ATOM   6271 O OE1 . GLU B 2 142 ? 53.560  -13.635 65.779  1.00 132.00 ? 438 GLU B OE1 1 
ATOM   6272 O OE2 . GLU B 2 142 ? 54.847  -15.420 65.602  1.00 123.28 ? 438 GLU B OE2 1 
ATOM   6273 N N   . ALA B 2 143 ? 57.120  -12.518 60.288  1.00 121.62 ? 439 ALA B N   1 
ATOM   6274 C CA  . ALA B 2 143 ? 58.135  -11.679 59.656  1.00 122.44 ? 439 ALA B CA  1 
ATOM   6275 C C   . ALA B 2 143 ? 57.509  -10.569 58.809  1.00 130.10 ? 439 ALA B C   1 
ATOM   6276 O O   . ALA B 2 143 ? 57.924  -9.404  58.882  1.00 131.27 ? 439 ALA B O   1 
ATOM   6277 C CB  . ALA B 2 143 ? 59.067  -12.546 58.811  1.00 118.95 ? 439 ALA B CB  1 
ATOM   6278 N N   . GLU B 2 144 ? 56.499  -10.907 58.005  1.00 129.00 ? 440 GLU B N   1 
ATOM   6279 C CA  . GLU B 2 144 ? 55.786  -9.905  57.205  1.00 124.74 ? 440 GLU B CA  1 
ATOM   6280 C C   . GLU B 2 144 ? 54.801  -9.121  58.078  1.00 122.85 ? 440 GLU B C   1 
ATOM   6281 O O   . GLU B 2 144 ? 53.659  -9.547  58.272  1.00 119.09 ? 440 GLU B O   1 
ATOM   6282 C CB  . GLU B 2 144 ? 55.032  -10.566 56.039  1.00 124.27 ? 440 GLU B CB  1 
ATOM   6283 C CG  . GLU B 2 144 ? 55.863  -10.774 54.748  1.00 121.44 ? 440 GLU B CG  1 
ATOM   6284 C CD  . GLU B 2 144 ? 55.102  -11.518 53.621  1.00 120.38 ? 440 GLU B CD  1 
ATOM   6285 O OE1 . GLU B 2 144 ? 53.868  -11.332 53.491  1.00 116.60 ? 440 GLU B OE1 1 
ATOM   6286 O OE2 . GLU B 2 144 ? 55.740  -12.313 52.881  1.00 114.40 ? 440 GLU B OE2 1 
HETATM 6287 C C4  . XHT C 3 .   ? -7.860  51.791  81.008  1.00 106.73 ? 901 XHT A C4  1 
HETATM 6288 C C14 . XHT C 3 .   ? -7.173  59.970  80.545  1.00 81.19  ? 901 XHT A C14 1 
HETATM 6289 C C5  . XHT C 3 .   ? -7.487  52.669  82.140  1.00 102.14 ? 901 XHT A C5  1 
HETATM 6290 C C6  . XHT C 3 .   ? -7.403  52.177  83.428  1.00 100.15 ? 901 XHT A C6  1 
HETATM 6291 C C11 . XHT C 3 .   ? -6.201  56.640  81.232  1.00 91.61  ? 901 XHT A C11 1 
HETATM 6292 C C7  . XHT C 3 .   ? -7.060  53.019  84.457  1.00 95.17  ? 901 XHT A C7  1 
HETATM 6293 C C8  . XHT C 3 .   ? -6.791  54.347  84.199  1.00 93.99  ? 901 XHT A C8  1 
HETATM 6294 C C9  . XHT C 3 .   ? -6.882  54.858  82.919  1.00 95.04  ? 901 XHT A C9  1 
HETATM 6295 C C10 . XHT C 3 .   ? -6.600  56.317  82.663  1.00 93.54  ? 901 XHT A C10 1 
HETATM 6296 C C12 . XHT C 3 .   ? -7.464  57.296  80.721  1.00 96.02  ? 901 XHT A C12 1 
HETATM 6297 C C13 . XHT C 3 .   ? -7.256  59.355  81.773  1.00 81.90  ? 901 XHT A C13 1 
HETATM 6298 N N1  . XHT C 3 .   ? -8.836  49.159  78.162  1.00 108.22 ? 901 XHT A N1  1 
HETATM 6299 N N2  . XHT C 3 .   ? -7.994  49.872  78.991  1.00 103.36 ? 901 XHT A N2  1 
HETATM 6300 C C3  . XHT C 3 .   ? -8.279  49.645  80.219  1.00 109.73 ? 901 XHT A C3  1 
HETATM 6301 N N3  . XHT C 3 .   ? -7.888  50.460  81.198  1.00 108.39 ? 901 XHT A N3  1 
HETATM 6302 C C1  . XHT C 3 .   ? -9.917  46.967  78.086  1.00 118.37 ? 901 XHT A C1  1 
HETATM 6303 C C15 . XHT C 3 .   ? -6.583  61.195  80.432  1.00 79.19  ? 901 XHT A C15 1 
HETATM 6304 C C16 . XHT C 3 .   ? -6.477  61.881  79.105  1.00 71.84  ? 901 XHT A C16 1 
HETATM 6305 C C17 . XHT C 3 .   ? -6.062  61.823  81.598  1.00 78.98  ? 901 XHT A C17 1 
HETATM 6306 C C18 . XHT C 3 .   ? -5.412  63.165  81.478  1.00 72.11  ? 901 XHT A C18 1 
HETATM 6307 C C19 . XHT C 3 .   ? -6.160  61.199  82.808  1.00 80.31  ? 901 XHT A C19 1 
HETATM 6308 C C2  . XHT C 3 .   ? -9.315  48.146  78.765  1.00 114.01 ? 901 XHT A C2  1 
HETATM 6309 C C20 . XHT C 3 .   ? -6.754  59.949  82.900  1.00 83.35  ? 901 XHT A C20 1 
HETATM 6310 C C21 . XHT C 3 .   ? -6.326  59.905  85.340  1.00 74.52  ? 901 XHT A C21 1 
HETATM 6311 C C22 . XHT C 3 .   ? -7.309  60.786  86.034  1.00 75.50  ? 901 XHT A C22 1 
HETATM 6312 C C23 . XHT C 3 .   ? -6.839  61.327  87.382  1.00 71.58  ? 901 XHT A C23 1 
HETATM 6313 C C24 . XHT C 3 .   ? -6.988  62.823  87.584  1.00 69.08  ? 901 XHT A C24 1 
HETATM 6314 C C25 . XHT C 3 .   ? -6.444  63.262  88.916  1.00 68.39  ? 901 XHT A C25 1 
HETATM 6315 C C26 . XHT C 3 .   ? -6.015  69.673  89.177  1.00 62.69  ? 901 XHT A C26 1 
HETATM 6316 C C27 . XHT C 3 .   ? -6.789  70.954  89.260  1.00 62.24  ? 901 XHT A C27 1 
HETATM 6317 C C28 . XHT C 3 .   ? -6.083  73.041  88.662  1.00 65.37  ? 901 XHT A C28 1 
HETATM 6318 C C29 . XHT C 3 .   ? -3.729  73.675  88.027  1.00 64.96  ? 901 XHT A C29 1 
HETATM 6319 C C30 . XHT C 3 .   ? -3.589  75.598  88.877  1.00 65.18  ? 901 XHT A C30 1 
HETATM 6320 C C31 . XHT C 3 .   ? -3.249  76.869  89.338  1.00 66.28  ? 901 XHT A C31 1 
HETATM 6321 C C32 . XHT C 3 .   ? -5.363  76.983  90.226  1.00 64.16  ? 901 XHT A C32 1 
HETATM 6322 C C33 . XHT C 3 .   ? -4.847  75.148  89.166  1.00 63.67  ? 901 XHT A C33 1 
HETATM 6323 C C34 . XHT C 3 .   ? -6.399  72.305  87.384  1.00 63.78  ? 901 XHT A C34 1 
HETATM 6324 C C35 . XHT C 3 .   ? -7.472  71.403  87.966  1.00 64.87  ? 901 XHT A C35 1 
HETATM 6325 C C36 . XHT C 3 .   ? -7.545  58.156  84.223  1.00 80.54  ? 901 XHT A C36 1 
HETATM 6326 C C37 . XHT C 3 .   ? -8.839  56.864  85.459  1.00 80.93  ? 901 XHT A C37 1 
HETATM 6327 C C38 . XHT C 3 .   ? -9.070  56.634  83.166  1.00 82.98  ? 901 XHT A C38 1 
HETATM 6328 C C39 . XHT C 3 .   ? -7.745  57.317  83.006  1.00 85.46  ? 901 XHT A C39 1 
HETATM 6329 C C40 . XHT C 3 .   ? -7.226  54.006  81.886  1.00 97.76  ? 901 XHT A C40 1 
HETATM 6330 N N10 . XHT C 3 .   ? -5.793  75.799  89.839  1.00 62.37  ? 901 XHT A N10 1 
HETATM 6331 N N11 . XHT C 3 .   ? -7.996  57.835  85.373  1.00 78.68  ? 901 XHT A N11 1 
HETATM 6332 N N12 . XHT C 3 .   ? -9.439  56.307  84.394  1.00 81.41  ? 901 XHT A N12 1 
HETATM 6333 N N4  . XHT C 3 .   ? -7.856  58.140  81.817  1.00 86.96  ? 901 XHT A N4  1 
HETATM 6334 N N5  . XHT C 3 .   ? -6.889  59.295  84.128  1.00 79.07  ? 901 XHT A N5  1 
HETATM 6335 N N6  . XHT C 3 .   ? -4.930  73.908  88.619  1.00 65.93  ? 901 XHT A N6  1 
HETATM 6336 N N7  . XHT C 3 .   ? -2.891  74.659  88.156  1.00 63.85  ? 901 XHT A N7  1 
HETATM 6337 N N8  . XHT C 3 .   ? -2.072  77.429  89.138  1.00 67.90  ? 901 XHT A N8  1 
HETATM 6338 N N9  . XHT C 3 .   ? -4.174  77.545  90.034  1.00 62.14  ? 901 XHT A N9  1 
HETATM 6339 O O1  . XHT C 3 .   ? -8.126  52.260  79.921  1.00 112.12 ? 901 XHT A O1  1 
HETATM 6340 O O10 . XHT C 3 .   ? -7.684  66.592  88.069  1.00 59.71  ? 901 XHT A O10 1 
HETATM 6341 O O11 . XHT C 3 .   ? -5.472  67.703  87.501  1.00 57.04  ? 901 XHT A O11 1 
HETATM 6342 O O12 . XHT C 3 .   ? -6.928  68.601  89.234  1.00 69.06  ? 901 XHT A O12 1 
HETATM 6343 O O13 . XHT C 3 .   ? -5.849  72.003  89.561  1.00 62.60  ? 901 XHT A O13 1 
HETATM 6344 O O14 . XHT C 3 .   ? -6.924  73.187  86.433  1.00 60.73  ? 901 XHT A O14 1 
HETATM 6345 O O15 . XHT C 3 .   ? -8.563  72.257  88.263  1.00 68.29  ? 901 XHT A O15 1 
HETATM 6346 O O16 . XHT C 3 .   ? -9.103  56.437  86.546  1.00 75.13  ? 901 XHT A O16 1 
HETATM 6347 O O17 . XHT C 3 .   ? -9.788  56.406  82.219  1.00 87.25  ? 901 XHT A O17 1 
HETATM 6348 O O2  . XHT C 3 .   ? -8.459  56.342  80.552  1.00 92.48  ? 901 XHT A O2  1 
HETATM 6349 O O3  . XHT C 3 .   ? -7.513  61.845  85.197  1.00 76.23  ? 901 XHT A O3  1 
HETATM 6350 O O4  . XHT C 3 .   ? -5.506  61.073  87.550  1.00 73.66  ? 901 XHT A O4  1 
HETATM 6351 O O5  . XHT C 3 .   ? -8.371  63.118  87.560  1.00 74.94  ? 901 XHT A O5  1 
HETATM 6352 O O6  . XHT C 3 .   ? -7.026  64.498  89.353  1.00 70.88  ? 901 XHT A O6  1 
HETATM 6353 O O7  . XHT C 3 .   ? -7.212  65.643  91.524  1.00 70.61  ? 901 XHT A O7  1 
HETATM 6354 O O8  . XHT C 3 .   ? -5.057  64.613  90.840  1.00 56.57  ? 901 XHT A O8  1 
HETATM 6355 O O9  . XHT C 3 .   ? -5.839  66.552  89.632  1.00 59.14  ? 901 XHT A O9  1 
HETATM 6356 P P1  . XHT C 3 .   ? -6.277  65.303  90.456  1.00 65.51  ? 901 XHT A P1  1 
HETATM 6357 P P2  . XHT C 3 .   ? -6.495  67.331  88.462  1.00 63.25  ? 901 XHT A P2  1 
HETATM 6358 S S1  . XHT C 3 .   ? -9.185  48.247  80.462  1.00 124.16 ? 901 XHT A S1  1 
HETATM 6359 C C1  . XHX D 4 .   ? -7.296  44.209  80.335  1.00 130.66 ? 902 XHX A C1  1 
HETATM 6360 C C10 . XHX D 4 .   ? -2.703  53.282  84.688  1.00 109.24 ? 902 XHX A C10 1 
HETATM 6361 C C11 . XHX D 4 .   ? -2.956  52.966  86.127  1.00 107.31 ? 902 XHX A C11 1 
HETATM 6362 C C12 . XHX D 4 .   ? -1.713  52.447  85.465  1.00 103.53 ? 902 XHX A C12 1 
HETATM 6363 C C13 . XHX D 4 .   ? 0.548   52.102  85.394  1.00 101.91 ? 902 XHX A C13 1 
HETATM 6364 C C14 . XHX D 4 .   ? 0.210   51.068  84.319  1.00 94.43  ? 902 XHX A C14 1 
HETATM 6365 C C15 . XHX D 4 .   ? -0.034  50.068  85.450  1.00 93.42  ? 902 XHX A C15 1 
HETATM 6366 C C16 . XHX D 4 .   ? 0.861   50.939  86.335  1.00 94.28  ? 902 XHX A C16 1 
HETATM 6367 C C17 . XHX D 4 .   ? -3.805  51.299  83.682  1.00 106.00 ? 902 XHX A C17 1 
HETATM 6368 C C2  . XHX D 4 .   ? -6.560  45.320  81.006  1.00 141.26 ? 902 XHX A C2  1 
HETATM 6369 C C3  . XHX D 4 .   ? -5.816  47.436  81.641  1.00 135.15 ? 902 XHX A C3  1 
HETATM 6370 C C4  . XHX D 4 .   ? -4.867  49.247  82.749  1.00 120.91 ? 902 XHX A C4  1 
HETATM 6371 C C5  . XHX D 4 .   ? -4.449  50.662  82.638  1.00 108.80 ? 902 XHX A C5  1 
HETATM 6372 C C6  . XHX D 4 .   ? -4.718  51.353  81.473  1.00 106.49 ? 902 XHX A C6  1 
HETATM 6373 C C7  . XHX D 4 .   ? -4.344  52.672  81.358  1.00 106.09 ? 902 XHX A C7  1 
HETATM 6374 C C8  . XHX D 4 .   ? -3.693  53.299  82.403  1.00 105.92 ? 902 XHX A C8  1 
HETATM 6375 C C9  . XHX D 4 .   ? -3.432  52.628  83.571  1.00 109.97 ? 902 XHX A C9  1 
HETATM 6376 N N1  . XHX D 4 .   ? -6.351  45.381  82.270  1.00 135.10 ? 902 XHX A N1  1 
HETATM 6377 N N2  . XHX D 4 .   ? -5.909  46.636  82.657  1.00 133.78 ? 902 XHX A N2  1 
HETATM 6378 N N3  . XHX D 4 .   ? -5.654  48.753  81.778  1.00 123.46 ? 902 XHX A N3  1 
HETATM 6379 N N4  . XHX D 4 .   ? -0.469  53.054  85.785  1.00 105.12 ? 902 XHX A N4  1 
HETATM 6380 O O1  . XHX D 4 .   ? -4.517  48.546  83.681  1.00 125.83 ? 902 XHX A O1  1 
HETATM 6381 S S1  . XHX D 4 .   ? -5.919  46.662  80.141  1.00 147.07 ? 902 XHX A S1  1 
# 
